PharMolix/UniProtQA huggingface dataset:
Protein: STHA_SALPB
Sequence: MPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNAHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPNDVDFSHPRIYDSDSILSLHHEPRHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVNSMYQTALPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTC9A_HUMAN
Sequence: MERKGSAAGAKGNPSPPAAGEGQRPPPPLCVPGGGGGAPARGQVGAAAEPAELIRRAHEFKSQGAQCYKDKKFREAIGKYHRALLELKGLLPPPGERERDSRPASPAGALKPGRLSEEQSKTVEAIEIDCYNSLAACLLQAELVNYERVKEYCLKVLKKEGENFKALYRSGVAFYHLGDYDKALYYLKEARTQQPTDTNVIRYIQLTEMKLSRCSQREKEAM
What are the official names of this protein?
Tetratricopeptide repeat protein 9A, TPR repeat protein 9A.
What is the protein family that this protein belongs to?
Belongs to the TTC9 family.
Protein: ATX1L_HUMAN
Sequence: MKPVHERSQECLPPKKRDLPVTSEDMGRTTSCSTNHTPSSDASEWSRGVVVAGQSQAGARVSLGGDGAEAITGLTVDQYGMLYKVAVPPATFSPTGLPSVVNMSPLPPTFNVASSLIQHPGIHYPPLHYAQLPSTSLQFIGSPYSLPYAVPPNFLPSPLLSPSANLATSHLPHFVPYASLLAEGATPPPQAPSPAHSFNKAPSATSPSGQLPHHSSTQPLDLAPGRMPIYYQMSRLPAGYTLHETPPAGASPVLTPQESQSALEAAAANGGQRPRERNLVRRESEALDSPNSKGEGQGLVPVVECVVDGQLFSGSQTPRVEVAAPAHRGTPDTDLEVQRVVGALASQDYRVVAAQRKEEPSPLNLSHHTPDHQGEGRGSARNPAELAEKSQARGFYPQSHQEPVKHRPLPKAMVVANGNLVPTGTDSGLLPVGSEILVASSLDVQARATFPDKEPTPPPITSSHLPSHFMKGAIIQLATGELKRVEDLQTQDFVRSAEVSGGLKIDSSTVVDIQESQWPGFVMLHFVVGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRTTQLFSLPCHRLQVGDVCISISLQSLNSNSVSQASCAPPSQLGPPRERPERTVLGSRELCDSEGKSQPAGEGSRVVEPSQPESGAQACWPAPSFQRYSMQGEEARAALLRPSFIPQEVKLSIEGRSNAGK
What is the function of this protein?
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor.  Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249).  Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1).  In concert with CIC and ATXN1, involved in brain development (By similarity).
What are the official names of this protein?
Ataxin-1-like, Brother of ataxin-1, Brother of ATXN1.
What is the protein family that this protein belongs to?
Belongs to the ATXN1 family.
What are the subcellular locations of this protein?
Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
Protein: KAR5_KLULA
Sequence: MWFLVFSIWIASGQLLPHISNVIEKELDQLEITELSREYINNKFPITQSSCVKNALGEFLEICMRKGFEFVDADLRVITAVRLSVCEFESSGLTNYPSECHEKRLGGIDTISCVNALESSPQWWTTYSGNYQNLPHICMENSLPFEKEQILELFLNITDMYSEFQRNIENYWKSFSSDLEINGKENIDMIQNLFNSLVNDLIQNHKMKDEELITEFDKMKAEFDIRFFNFTESFDNLNDEVNEDLSLIKSHLIETFRQVDSEYMAQLQKNKNSTDKAFNELESMSTYILDHQKTSMELIDSFFSDLIDLTRDKNLVISDELMQTQEETIHLIFQYNKLVHESVIPLLTDDLLPVVRGVSNSIVENLDNMNVELTSHLENVSQTIEVKFKALEKETDRSLLKAKEVESNLRNLNNLVSTSLKGLQTIVRLLTFLLKRQVVLVGILQIFLRKYISMNLYLYAIAVVVTALAGSKVGSWGSLLMKSFVTR
What is the function of this protein?
Required for nuclear membrane fusion during karyogamy.
What are the official names of this protein?
Nuclear fusion protein KAR5, Karyogamy protein 5.
What is the protein family that this protein belongs to?
Belongs to the KAR5 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Protein: SLE1_STAAS
Sequence: MQKKVIAAIIGTSAISAVAATQANAATTHTVKPGESVWAISNKYGISIAKLKSLNNLTSNLIFPNQVLKVSGSSNSTSNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQNIMRLNGLNNFFIYPGQKLKVSGTASSSNAASNSSRPSTNSGGGSYYTVQAGDSLSLIASKYGTTYQKIMSLNGLNNFFIYPGQKLKVTGNASTNSGSATTTNRGYNTPVFSHQNLYTWGQCTYHVFNRRAEIGKGISTYWWNANNWDNAAAADGYTIDNRPTVGSIAQTDVGYYGHVMFVERVNNDGSILVSEMNYSAAPGILTYRTVPAYQVNNYRYIH
What is the function of this protein?
Peptidoglycan hydrolase involved in the splitting of the septum during cell division.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase sle1.
What are the subcellular locations of this protein?
Secreted. Cell surface.
Protein: RL25_SHEPA
Sequence: MSYTIAAQVRTEIGKGSSRRLRHAKKVPAVIYGPGKEAISIVFDHKDIINIQENQDFYTSELTIALEGKDVKVRVQDMQRHAFKPMIEHVDFKFA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: RFU1_ASHGO
Sequence: MKSSAQLCMEARNYNFNAAAPLRLYLATCVRLVEEAQAAAQADDVARAYMLYVRYLDLCMHQLSGHREVQQPVTDAERLSRDEYEQLLRLEVPAVLRLTEELKSAVDLRHERGRASLARSVVPEAGRGEHSRQEVQLPPSFDEERFNRTVQWFLAAGRSMSLPVSAEEPAVREVFSYPELPKLSMAAESWAPS
What is the function of this protein?
Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.
What are the official names of this protein?
Regulator of free ubiquitin chains 1.
What is the protein family that this protein belongs to?
Belongs to the RFU1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: HMUV_BURCM
Sequence: MLTAHHLDVARRHNVILRDLSLSIEPGRVTALLGRNGAGKSTLLKTFAGELTGSVAPNGVRVTGDITLNGEPLACIDARRLACLRAVLPQAAQPAFPFSVDEIVLLGRYPHVRRGGATSHRDRDIAWQALERADADALVGRDVTTLSGGELARVQFARVLAQLWPDDDAMEAGPRYLLLDEPTAALDLAHQHRLLDTVRAVAREWRLGVLAIVHDPNLAARHADSIALLADGTIVAHGTPRDVMTPAHIAQCYGFAVKMVETGDGAPPVMVPA
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y367_HAEIN
Sequence: MNPTTEQVLSPGEIFRQTREALNLSLEDVAKEITLRPSILEQLENNEFIQKSTPAIFVKGYVRSYAKFLRLPDSVWENIVFAETEKNDLGKNARSTRAVNQYSSHNRWIGRLTAIVFMIVIGMTGLWWWQSYQQNTQERDDLVQSYVASTENNQPATALVTTEESNKTVPETAAPVSQPVEITNNLLPEIAQENSVSQPKNDEKSVSEIQSAVENPSISPTLPIAKGDLVIEILTNSSWISVKDNARHVLAQKEYKQGEILTFNGNEFSLIVGAPSNVRITYKGENYPLKVDGRVAKFKLSQP
What are the official names of this protein?
Uncharacterized protein HI_0367.
Protein: YBEY_BORRA
Sequence: MIKEELNLWAEGVEFRHLDAYYNFILSVLNFLCIKEYELSVILCNNEYIQKLNGEFRQKPEPTDVLSFNYFEGSEQINHKIQGDIVISLEYLEFSSLEFNVEMYEELQRNTIHGILHLIGYTHDTNDFQNETMLIIQERVLRETRRVF
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_ALTMD
Sequence: MSSTTALHTKHLEAGAKMVDFFGWDMPINYGSQIEEHHAVRQDAGMFDVSHMTIVDVKGAQAKAYLQYLLANDVAKLKDKGKALYSGMLNEEGGVVDDLIVYHFDETNYRLVVNSATREKDMNWLMSKAEGFDVTITERPEFAMIAVQGPNAKEKAATLFSAAQKEAVAGMKPFFGVQAEDLFIATTGYTGEAGYEIMVPAEQAESFWQALLDAGVKPCGLGARDTLRLEAGMNLYGQDMDETVSPLAANMGWTITWEPAERDFVGRKALEAQREAGTDKLVGLVMTEKGVLRHGLKVKTESGEGVITSGTFSPTLGHSIAMARVPRDVGETVEVEMRKKWVTVKVVKPSFVRNGKSVL
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: RS13_ORITI
Sequence: MARISNVNVPTNKRVMIGLTYIYGIGRSTAQKICQEVQVSVNKKVKDLSNQELVALRSIIESKYKVEGDLRREINLNIKKKKDIRCYEGLRHIRKLPVRGQNTHSNARTRKGKAIAIAGKKKPNK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: TPP1_PANTR
Sequence: MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKYLTLENVADLVRPSPLTLRTVQKWLLAAGARKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
What is the function of this protein?
Lysosomal serine protease with tripeptidyl-peptidase I activity.  May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases.  Requires substrates with an unsubstituted N-terminus (By similarity).
What are the official names of this protein?
Tripeptidyl-peptidase 1, TPP-1, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase I, TPP-I.
What are the subcellular locations of this protein?
Lysosome. Melanosome.
Protein: LGT_FRATH
Sequence: MLQYPHINPVALQLGPIKIHWYGLMYLLGIFAGWYLTRYRAKVKPWAPIKPEQVGDLTFYVALGVILGGRIGYIIFYNLPYYFHNPSQMFFLWDGGMSFHGGFIGVLIAFALFARKIGANFFDLGEFVAPVIPIGLGAGRIGNFINGELLGKVTDSPLGMVFPTGGPLPRYPSQLFEFFFEGVVLFSVLWLVTIKKRPRYLVLGLFMFLYGYARFICEFFRQPDPQYGYIFFNWMTMGQILSIPMILLGAVILIAVFIKTRKNKCENI
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOKC_ECOLI
Sequence: MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE
What is the function of this protein?
Might be the toxic component of a type I toxin-antitoxin (TA) system (By similarity).  Regulatory peptide which completely overlaps hokC and enables hokC expression.
What are the official names of this protein?
Regulatory protein MokC.
What is the protein family that this protein belongs to?
Belongs to the Hok/Gef family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RS21_TOLAT
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLSDVRSREFYEKPTTIRKRAKASAVKRHMKKLARENARRNRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: NIFD_AZOBR
Sequence: MSLSVNEGVDVKGLVDKVLEAYPEKSRRRRAKHLNVLEAEAKDCGVKSNIKSIPGVMTIRGCAYAGSKGVVWGPIKDMIHISHGPVGCGYYSWSGRRNYYVGDTGVDKLGTMHFTSDFQEKDIVFGGDKKLHKVIEEINELFPLVNGISIQSECPIGLNGDDIEGVSKAKSEELGKPVVPVRCEGFRGVSQSLGHHIANDVIRDWILPKKTEPKEGFVSTPYDVTIIGDYNIGGDAWASRILLEEIGLRVIAQWSGDGTLAELENQPKAKVNLIHSYRSMNYIARHMEEKFGIPWMEYNFFGPSQIAESLRKIAALFDDTIKENAEKVIAKYQPMVDAVVGDAALRAHGTKGRVPLKPLGPRHRPIVDAYHDLGMEIVGTGYEFAHNDDYQRTQHYVKEGTLIYDDVTAFELEKFVELMRPDLVASGIKEKYVFQKMGLPFRQMHSWDYSGPYHGYDGFAIFARDMDLAINNPVWGIMKAPF
What is the function of this protein?
This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
What are the official names of this protein?
Nitrogenase molybdenum-iron protein alpha chain, Dinitrogenase, Nitrogenase component I.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: RL24_ACIC1
Sequence: MAGLKVRKGDTVQVIAGKDRGTKGKVIAAFPREQKLLVEGVNRVRRHTKVTATTRGSKTGGIITKEAPIHVSNVMVVCPECEKPTRLGRRQDVVDASTGKTRPVRICKRCGKEI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: A423_LOXLA
Sequence: WIMGHMVNKIEQINEFLDLGANSIEVDIAFDELGYPEYTYHGVPCDCKRYCTKSEKIDDFIEALSAATTPGNPKFRKELTLVVFDLKTGGFDASRMYKSGKAFAELIQFSYWKGSDDAGRAYIVLSLPKLDHYEFIKAFREHFDTSTFKNLLEERVGYDFSGNEDMGLTRVVLDKAGVNDREHVWQGDGITNCILRSLDRVKAAVAIRDSATGYINKVYFWTIQAYSSVRDALNAEVDGIMTNEPDVIANILKEDAFKDRFRLATYRDNPWETFKR
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LlSicTox-alphaIV2iii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPD_DESPS
Sequence: MAVTLGKNNMNIRQAIARVVTGADLSESEMMASMEEVMSGQASPAQIASFITALRMKGEAVEEIVGAVRVMRDKATFIDCGLGPDDILMDIVGTGGDGADTFNVSTTTSFVVAAAGVAVAKHGNRAVSSRCGSADVLEALGVDLSLDPATVARSVQEIGIGFLFAPLLHAAMKHAIVPRREMGIRTIFNILGPLTNPAGANVQLIGVFERSLTTVLAEVLLRLGERRSLVVWGEGNMDEMTVTGTSYIADAHDGRVTSYAVEPEDVGLARAAVADISGGRTPEESAQQVRAVLAGEKGARLDMVLLNAGAALLAAGRVETIVEGVVMARDVVESGAALKKLGQLVAFR
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: PUS1_CANGA
Sequence: MEEVAPEQVQEVQGNTEAHIDSTTASTAPTEALPSDKQSRKANEIDSMADGAPAEKKQKTDQRQIIREPKLDDNGNPIPREPRLPKRKVAVMIGYCGTGYHGMQYNPPNPTIEAALFKAFVDAGAISKANSNDLKKNNFMRAARTDKGVHAGGNLISLKMIIEDPEIMDKINANLPEGIRIWDIERVNKAFDCRKMCSSRWYEYLLPTYSLIGPKPGTILNNDIESSKTELPGVLDEDLESKEFWENFEAAAKKEFTPEEIAAIKDYSPPPREEFDDQEELYQKVKQWKLLENTHRRQYRISEMKLNKFRAAMNQYLGAHNFHNFTLGKEFKDPSAIRFMKEIKVSDPFVIGDAKAEWVSIKIHGQSFMLHQIRKMISMATLIARCGTPVERISQAFGPQKINIPKAPALGLLLEAPVFESYNKRLEKFGYKPIDFSKYQEKVDAFKMKHIYDKIYAEEVSDNVFNAFFSYIDSFNKVTGAQTEESAESNKPATKSIFEFLSAHGIPGIDYGKNEKEDSNKESSNDQVNKESAPATSKPAEAVEQTEKN
What is the function of this protein?
Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr).  Catalyzes pseudouridylation at position 44 in U2 snRNA.  Also catalyzes pseudouridylation of mRNAs.
What are the official names of this protein?
tRNA pseudouridine synthase 1, tRNA pseudouridylate synthase 1, tRNA-uridine isomerase 1.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y491_MYCBO
Sequence: MPRSFDMSADYEGSVEEVHRAFYEADYWKARLAETPVDVATLESIRVGGDSGDDGTIEVVTLQMVRSHNLPGLVTQLHRGDLSVRREETWGPVKEGIATASIAGSIVDAPVNLWGTAVLSPIPESGGSRMTLQVTIQVRIPFIGGKLERLIGTQLSQLVTIEQRFTTLWITNNV
What are the official names of this protein?
Uncharacterized protein Mb0491c.
Protein: L2GL1_HUMAN
Sequence: MMKFRFRRQGADPQREKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAATVTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGASAPLSLTRVTVVLLVAASDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKALGPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGNQQLESLCWGRDSSTVVSSHSDGSYAVWSVDAGSFPTLQPTVATTPYGPFPCKAINKILWRNCESGGHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAAEDDWPPFRKVGCFDPYSDDPRLGVQKVALCKYTAQMVVAGTAGQVLVLELSDVPVEQAVSVAIIDLLQDREGFTWKGHERLSPRTGPLPWPAGFQPRVLVQCLPPAAVTAVTLHTEWSLVAFGTSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRAANASSKLQEANAQLAEQACPHDVEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDGAHHGPTMWAGTNSGSVFAYALEVPAAAVGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFASVACEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDISGIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDINWPRDATQASYRIRESPKLSQANGTPSILLAPQSLDGSPDPAHSMGPDTPEPPEAALSPMSIDSATSADTTLDTTGDVTVEDVKDFLGSSEESEKNLRNLAEDEAHACAILIK
What is the function of this protein?
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity.  Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells.  Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
What are the official names of this protein?
Lethal(2) giant larvae protein homolog 1, LLGL, DLG4, Hugl-1, Human homolog to the D-lgl gene protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat L(2)GL family.
What are the subcellular locations of this protein?
Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity).
Protein: HMDH_BOVIN
Sequence: MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKLEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLVDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKITDDCCRRDPVLVRNDQKFHAMEEETRKNRERKVEVIKPLLAENDTSHRATFVVGNSSLLGTSLELETQEPEMELPVEPRPNEECLQILENAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRFPRACDSAEVKAWLETPEGFTVIKEAFDSTSRFARLQKLHMSVAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLQEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACRDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA
What is the function of this protein?
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
Protein: PECA1_MOUSE
Sequence: MLLALGLTLVLYASLQAEENSFTINSIHMESLPSWEVMNGQQLTLECLVDISTTSKSRSQHRVLFYKDDAMVYNVTSREHTESYVIPQARVFHSGKYKCTVMLNNKEKTTIEYEVKVHGVSKPKVTLDKKEVTEGGVVTVNCSLQEEKPPIFFKIEKLEVGTKFVKRRIDKTSNENFVLMEFPIEAQDHVLVFRCQAGILSGFKLQESEPIRSEYVTVQESFSTPKFEIKPPGMIIEGDQLHIRCIVQVTHLVQEFTEIIIQKDKAIVATSKQSSEAVYSVMAMVEYSGHYTCKVESNRISKASSIMVNITELFPKPKLEFSSSRLDQGELLDLSCSVSGTPVANFTIQKEETVLSQYQNFSKIAEESDSGEYSCTAGIGKVVKRSGLVPIQVCEMLSKPSIFHDAKSEIIKGHAIGISCQSENGTAPITYHLMKAKSDFQTLEVTSNDPATFTDKPTRDMEYQCRADNCHSHPAVFSEILRVRVIAPVDEVVISILSSNEVQSGSEMVLRCSVKEGTSPITFQFYKEKEDRPFHQAVVNDTQAFWHNKQASKKQEGQYYCTASNRASSMRTSPRSSTLAVRVFLAPWKKGLIAVVVIGVVIATLIVAAKCYFLRKAKAKQKPVEMSRPAAPLLNSNSEKISEPSVEANSHYGYDDVSGNDAVKPINQNKDPQNMDVEYTEVEVSSLEPHQALGTRATETVYSEIRKVDPNLMENRYSRTEGSLNGT
What is the function of this protein?
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity).  Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity).  Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity).  Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (By similarity).  Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (By similarity).  Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (By similarity).  Modulates bradykinin receptor BDKRB2 activation (By similarity).  Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (By similarity).  Induces susceptibility to atherosclerosis (PubMed:19048083).
What are the official names of this protein?
Platelet endothelial cell adhesion molecule, PECAM-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.
Protein: PLSY_ECO55
Sequence: MSAIAPGMILIAYLCGSISSAILVCRLCGLPDPRTSGSGNPGATNVLRIGGKGAAVAVLIFDVLKGMLPVWGAYELGVSPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKFKRKREKDPE
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.