PharMolix/UniProtQA huggingface dataset:
Protein: CYB_STECO
Sequence: MTNIRKTHPLMKILNDAFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTSTAFSSVAHICRDVNYGWFIRYLHANGASMFFICLYAHIGRGLYYGSYMFQETWNIGVLLLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAAVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGALLLILTLLALTLFTPDLLGDPDNYTPANPLSTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILVLIFIPMLQTSKQRSMMFRPFSQLLFWTLIADLLTLTWIGGQPVEHPYIIVGQLASILYFLLILVLMPTAGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NCE2_YEAST
Sequence: MLALADNILRIINFLFLVISIGLISSLLNTQHRHSSRVNYCMFACAYGIFTDSLYGVFANFIEPLAWPLVLFTLDFLNFVFTFTAGTVLAVGIRAHSCNNSSYVDSNKITQGSGTRCRQAQAAVAFLYFSCAIFLAKTLMSVFNMISNGAFGSGSFSKRRRTGQVGVPTISQV
What is the function of this protein?
Involved in membrane organization.  Required for the formation of membrane compartments of CAN1 (MCCs), localization of CAN1 at the MCCs and subsequent invagination of the plasma membrane at the MCCs sites.  Involved in eisosome organization and might act as a sensor of sphingolipids that regulates plasma membrane function.  Involved in a novel pathway of export of proteins that lack a cleavable signal sequence.  It may be an accessory subunit to an essential core component of the non-classical export machinery.  Non-classical export pathway functions also as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient.
What are the official names of this protein?
Non-classical export protein 2.
What is the protein family that this protein belongs to?
Belongs to the NCE102 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Associates with the ergosterol-rich membrane compartment of CAN1 (MCC). Accumulates in membrane domains at eisosomes.
Protein: COBO_PSEAE
Sequence: MNESPEKDQRHRERMERKKAVVDEKIAQARDERGVLLVHSGNGKGKSSSAFGMVARALGHGMKVGVVQFIKGAASTGEEAFFRRFPEEVSYHVMGEGFTWETQDRQRDIAKAEAAWKVAAQLLADPDVGLVVLDELNIALKHGYLELDRVLADIQARPAMQHVVVTGRGAQPGMIEAADTVTEMSLVKHAFKAGIKAQKGVEF
What is the function of this protein?
Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids.  Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity).
What are the official names of this protein?
Corrinoid adenosyltransferase, Cob(II)alamin adenosyltransferase, Cob(II)yrinic acid a,c-diamide adenosyltransferase, Cobinamide/cobalamin adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Cob(I)alamin adenosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3_STAAE
Sequence: MAMTEQQKFKVLADQIKISNQLDAEILNSGELTRIDVSNKNRTWEFHITLPQFLAHEDYLLFINAIEQEFKDIANVTCRFTVTNGTNQDEHAIKYFGHCIDQTALSPKVKGQLKQKKLIMSGKVLKVMVSNDIERNHFDKACNGSLIKAFRNCGFDIDKIIFETNDNDQEQNLASLEAHIQEEDEQSARLATEKLEKMKAEKAKQQDNNESAVDKCQIGKPIQIENIKPIESIIEEEFKVAIEGVIFDINLKELKSGRHIVEIKVTDYTDSLVLKMFTRKNKDDLEHFKALSVGKWVRAQGRIEEDTFIRDLVMMMSDIEEIKKATKKDKAEEKRVEFHLHTAMSQMDGIPNIGAYVKQAADWGHPAIAVTDHNVVQAFPDAHAAAEKHGIKMIYGMEGMLVDDGVPIAYKPQDVVLKDATYVVFDVETTGLSNQYDKIIELAAVKVHNGEIIDKFERFSNPHERLSETIINLTHITDDMLVDAPEIEEVLTEFKEWVGDAIFVAHNASFDMGFIDTGYERLGFGPSTNGVIDTLELSRTINTEYGKHGLNFLAKKYGVELTQHHRAIYDTEATAYIFIKMVQQMKELGVLNHNEINKKLSNEDAYKRARPSHVTLIVQNQQGLKNLFKIVSASLVKYFYRTPRIPRSLLDEYREGLLVGTACDEGELFTAVMQKDQSQVEKIAKYYDFIEIQPPALYQDLIDRELIRDTETLHEIYQRLIHAGDTAGIPVIATGNAHYLFEHDGIARKILIASQPGNPLNRSTLPEAHFRTTDEMLNEFHFLGEEKAHEIVVKNTNELADRIERVVPIKDELYTPRMEGANEEIRELSYANARKLYGEDLPQIVIDRLEKELKSIIGNGFAVIYLISQRLVKKSLDDGYLVGSRGSVGSSFVATMTEITEVNPLPPHYICPNCKTSEFFNDGSVGSGFDLPDKTCETCGAPLIKEGQDIPFETFLGFKGDKVPDIDLNFSGEYQPNAHNYTKVLFGEDKVFRAGTIGTVAEKTAFGYVKGYLNDQGIHKRGAEIDRLVKGCTGVKRTTGQHPGGIIVVPDYMDIYDFTPIQYPADDQNSAWMTTHFDFHSIHDNVLKLDILGHDDPTMIRMLQDLSGIDPKTIPVDDKEVMQIFSTPESLGVTEDEILCKTGTFGVPEFGTGFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIKTGICDLSSVIGCRDDIMVYLMYAGLEPSMAFKIMESVRKGKGLTEEMIETMKENEVPDWYLDSCLKIKYMFPKAHAAAYVLMAVRIAYFKVHHPLYYYASYFTIRASDFDLITMIKDKTSIRNTVKDMYSRYMDLGKKEKDVLTVLEIMNEMAHRGYRMQPISLEKSQAFEFIIEGDTLIPPFISVPGLGENVAKRIVEARDDGPFLSKEDLNKKAGLSQKIIEYLDELGSLPNLPDKAQLSIFDM
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO3A_TOBAC
Sequence: MASTASYSPSPTSQWRTQKLPKRFNFYVIHNQEFGKLSQSSSLPTSSFPKTLKLPVIQMPINNNIQSQTTVCVSTDENLEELVNLQKIANGVLTKESNKRVFIQDPPWVSSLFMNSLFVRAKQVQGVRREFREIERRRRYAMLRRRQIKAETEAWEQMVEEYRELEREMCEKKLAPNLPYVKKLLLGWFEPLRQAIEKEQNAETTVKHRAAFAPHIDSLPADKMAVIVMHKLMGLLMMGGKEERCVQVVQAAVQIGMAVENEVRIHNFLEKTKKLQKHMTGAQSQEDMSRETMILRKRVKSLIKRNRVVEVRKLMKSEEPESWGRDTQAKLGCRLLELLTETAYVQPPVDQSADTPPDIRPAFRHVFRIATRDPGKSIVKKYGVIECDPLVVAGVDRTVKQMMIPYVPMLVPPKKWRGYDKGGYLFLPSYLMRTHGSRRQQDAVRSVPTKQMQQVYEALDTLGSTKWRVNKRILSVVESIWAGGGNIAGLVDRKDVPIPELHSDDIMEVKKWKWRVRKSKKINQELHSQRCDTELKLSVARKLKDEEGFYYPHNLDFRGRAYPMHPHLNHLSSDLCRGILEFAEGRPLGKSGLRWLKIHLASLYAGGIEKLCYDARLAFVENHIDDILDSANNPLNGNRWWLNAEDPFQCLAACINLSEALKSSSPHTVFSHLPIHQDGSCNGLQHYAALGRDSMEAAAVNLVAGDKPADVYTEIALRVDHIIRGDSIKDPATDPNALLAKLLIDQVDRKLVKQTVMTSVYGVTYVGAREQIKRRLEEKGLIDDDRLLFTASCYAAKVTLAALGELFQAARGTMTWLGDCAKVIASENQPVRWTTPLGLPVVQPYFKTQRHVIRTSLQVLALQREGDTVEVRKQRTAFPPNFVHSLDGSHMMMTAVACRDAGLQFAGVHDSFWTHACDVDQMNRILREKFVELYSMPILEDLLESFQNSYPALTFPPLPKRGDFDLVEVLESPYFFN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase 3A, chloroplastic, NictaRpoT3-syl, T7 bacteriophage-type single subunit RNA polymerase 3A.
What is the protein family that this protein belongs to?
Belongs to the phage and mitochondrial RNA polymerase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MDM34_DEBHA
Sequence: MSFNVNWNSLETESLSSWTKELLTDALNSGKRPNILASGIQIKDLNFGKVGPSFEILEIGELDKDRFRGIFKINYEGDFHLTLHTKVQANPLKIYSSNSLDREVNQFDEMNNFVTPDFLLCNDPFALPLDLKLSDIKISGIGIIVFSQTKGLTLVFRNDPLDSIKVSSTFDTVQVLANFLQSQIEDQIGDLFRETLPTLIHELSLKYTSLNESNFSDLQSKLKSKMNNLDTEDLEKISINDVNSEFNYSSTNLRKNMNLFNSRETLNLSIPKLKNIVQRSHLEKFNKHLPNLVSTLNLNLNLPDVNVNNNIAPSQNNNCIPIDLLINNNNNLENILTEISSIQTSSYYNKLNSNNNGSKPNRRVIKLGGKKSKKASSANPLDQTPEYSEVSTLIDDSMEHSTIEHSTFESPVSLEHANLIDLKQPKPMRCTRDISIDTSKPILSHSHFHANGNSNTNSPHHPNSSLLRGVGLGNNYFNFTSNQQISTSHIENDEDRLMNKKSNNYIDIKSINNKSVDSKNIDQWKKLDFDKASLRQNCSSPQHNVFEVPPPPPYQY
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: RL14_BORGP
Sequence: MIQMQTYLTIADNTGGKLAQCIKVLGGSKRRYAKIGDIITIVVKQAIPNSSVKKGDVCKAVIIRTSKEVRRKNGTYVRFDDNACVILDANLSPRGKRVFGPVARELRDANFMKVVSLASEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MSCL_BURPS
Sequence: MSIIKEFKEFAVKGNVMDLAIGVIIGGAFSKIVDSVVKDLIMPVIGVLTGGLDFSNKFVLLGQIPASFKGNPESFKDLQAAGVATFGYGSFITVLINFIILAFIIFLMVKFINKLRKPEEAAPAATPEDVLLLREIRDSLKQR
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CEGT_RAT
Sequence: MALLDLAQEGMALFGFVLFVVLWLMHFMSIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIEVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPAYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTERVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWKFSMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRAGRYRLRCGGTAEEILDV
What is the function of this protein?
Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi.  Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) (PubMed:10393098, PubMed:1532799).  Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (By similarity).  Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction (By similarity).  They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity).  They are required for instance in the proper development and functioning of the nervous system.  As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (By similarity).  They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (By similarity).  The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity).  Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (By similarity).
What are the official names of this protein?
Ceramide glucosyltransferase, GLCT-1, Glucosylceramide synthase, GCS, Glycosylceramide synthase, UDP-glucose ceramide glucosyltransferase, UDP-glucose:N-acylsphingosine D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: COAD_XYLFT
Sequence: MSVVNRRIAVYPGTFDPITNGHIDLVSRAAPLFESVVVGVAQSPSKGPSLPLQQRVTLAREALCQHENVQVIGFDTLLAHFVRHVGAGVLLRGLRAVSDFEYEFQMASMNRHLIPEVETLFLTPAEQHSFISSSLVREIARLGGDVSGFAPAAVVAALRQNL
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_KLEP7
Sequence: MKPYQRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDRDLPYCFNRKEAKNHGEGGNLVGSPLQGRVMLVDDVITAGTAIRESMEIIQAQGALLAGVLISLDRQERGRGEISAIQEVERDYGCQVISIITLKELIAYLEEKPEMAEHLASVRAYREAYGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: DPP9_HUMAN
Sequence: MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL
What is the function of this protein?
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929).  Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36357533).  Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:34019797, PubMed:33731929, PubMed:33731932).  The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929).
What are the official names of this protein?
Dipeptidyl peptidase 9, DP9, Dipeptidyl peptidase IV-related protein 2, DPRP-2, Dipeptidyl peptidase IX, DPP IX, Dipeptidyl peptidase-like protein 9, DPLP9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family. DPPIV subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm, cytosol. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Protein: TENS4_RAT
Sequence: MSSSLLTGGHVVSLTPHEESRMALHPTPSHDLPALCPYYTTESWGTQPLMDPTLCKGSSNRLQQAQQAEARAQCLLQCPGEQASGASQDLDSCIDFSLEALNKMILELDPTFQLLPSGIAGPQAEPTNSVASRTKKEEPDALDIKYIEVTSTRSRCLDSPQRCSSPCVTPPFGSPRSGGLFLSRDIPRETRSSSNESLIFSGNQGRGSSPHTPSSLSNSIPCRESRASGSPLATPPGWEKGLRAPQWGSRVSTLSASPVSDISYVFGSNQSLPHSSLSSYPPSSRSLGSPASSSSSLHSLDRGSQCVRSSDAQVPSNPIVGMGQPQAVPSTPVAKEQASSCPPSVTNSMADIPIVLINGNPEPQSPPAQQTPRYQDSVQSRATSPSHLCQATKSHSKTLPDVPLTSPSHLCQATKSHSKTLPDVPLTASPESPAKDMQPTMKFVMDTSKYWFKPSITREQAINLLRTEKPGTFVIRDSSSYRGSFGLALKVQETPASAPNRPGEDSTDFIRHFLVESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQKELGGAEPASDSPTHGQTSCLKISAGCHTLYLTSVSVETLSGALAVQKAISVMLERDVLPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLIALRFCGMDPEQRKWQKYCKPSRIFGFVAKSQTEPQENACHLFAEYDAAQPASQVISLVTALLKDTERV
What is the function of this protein?
Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration.  Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF.  Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration.
What are the official names of this protein?
Tensin-4.
What is the protein family that this protein belongs to?
Belongs to the PTEN phosphatase protein family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
Protein: YACG_HAEIN
Sequence: MIEVPCPICQKSVPWINESTFRPFCSKRCQLIDLGEWAAEEKAIPSDTADFAMDPNVSDEWSIK
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: CSPLH_ARALL
Sequence: MTNPDKQKPVEVTDVETAAEKTSEPTPASGTSTITQRWKREDLIKKASPITRGICLLFSLLAFLIMVSNKHGYGRNFNEYEEYRYVLAISIISTLYTAWQTFAHFSKREFFDRRTSTLVDFSGDQIVAYLLISAASSAIPLTNRFREGQDNIFTDSAASAISMAIFAFVALALSALFSGYKLSTHSFI
What are the official names of this protein?
CASP-like protein 4B1, AlCASPL4B1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH10_STEMA
Sequence: MNIRXLHDRVIVKRKEVETKSAGGIVLTGSAAAKSTRGEVLAVGNGRILENGEVKPLDVKVGDIVIFNDGYGVKSEKIDNEEXLIMSDSDXLAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_SALA4
Sequence: MRVVILGSGVVGVTSAWYLSQAGHDVTVIDRESGPAQETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAVRLDGTPFQLKWMWQMLRNCDTRHYMENKGRMVRLAEYSRDCLKTLRAATGIEYEGRQGGTLQLFRTAQQYENATRDIAVLEDAGVPYQLLEASRLAEVEPALAEVAHKLTGGLRLPNDETGDCQLFTQRLARMAEQAGVTFRFNTPVEKLLYENDQIYGVKCADEIIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIVEPDGAPVSTILDETYKIAITRFDKRIRVGGMAEIVGFNTDLLQPRRETLEMVVRDLFPRGGHIEQATFWTGLRPMTPDGTPVVGRTRYKNLWLNTGHGTLGWTMACGSGQLLSDILSGRTPAIPYDDLSVARYRSDFTPTRPQRLHSAHN
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: GWL_BOVIN
Sequence: MEPTMGGEMESGGGAATGECVNRIPVPRPPSIEEFTIVKPISRGAFGKVYLGQKGNRLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDIDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFHTPVAEGNHDTANVLSTQVSETSPLSQGLTCPMSVDQKDTTPYSSKLLKSCPEMVASHPRMPVKCLTSHLLQSRKRLATSSTSSPSHTFISSMESECHSSPRWEKDCQESDDAAGSTMMSWNTVEKPLCTKSVDAMETKSFNERDLELALSPIHNSSVVPATGNSYVNLAKKCSSGEVSWEARELDVNNINMTADTSQYCFHESNQRAVDSGGMTEEHLGKRSCKRIFELVDSSPRQGIIPNKKSCFEYECSNEMRDCYATQRTGFAFEVQDLKLLVYRDQQNDCVNKENVGSSFTDKHQTPEKSPVPMIEKNLMCELDDDCDKNSKKDYLSSSFLCSDGDRTPKSIHMDSDSSFPGISIMESPLGGQSLDPDKNIKESSLEESNIEDLLPVSPSCQESTLPKGVECPTIQDSNQKMLAPSSEVLKPLTSKRNAVAFRSFNSHINASNSSEPSKMSITSLDMMDVSCAYSGSYPTAITPTQRERSDMPYQQTPNQVKSETPYRTPKSVRRGAAPVDDGRILGTPDYLAPELLLARAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVDILLTIDDTKRAGMKELKHHPLFSGVDWENLQHQKMPFIPQPDDETDTSYFEARNNAQHLTVSGFSL
What is the function of this protein?
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance.  Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively.  ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A.  Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high.  Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase greatwall, GW, GWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes.
Protein: YEJM_ECOL6
Sequence: MVTHRQRYREKVSQMVSWGHWFALFNILLSLVIGSRYLFIADWPTTLAGRIYSYVSIIGHFSFLVFATYLLILFPLTFIVGSQRLMRFLSVILATAGMTLLLIDSEVFTRFHLHLNPIVWQLVINPDENEMARDWQLMFISVPVILLLELVFATWSWQKLRSLTRRRRFARPLAAFLFIAFIASHVVYIWADANFYRPITMQRANLPLSYPMTARRFLEKHGLLDAQEYQRRLIEQGNPDAVSVQYPLSELRYRDMGTGQNVLLITVDGLNYSRFEKQMPALAGFAEQNISFTRHMSSGNTTDNGIFGLFYGISPSYMDGILSTRTPAALITALNQQGYQLGLFSSDGFTSPLYRQALLSDFSMPSVRTQSDEQTATQWINWLGRYAQEDNRWFSWVSFNGTNIDDSNQQAFARKYSRAAGNVDDQINRVLNALRDSGKLDNTVVIITAGRGIPLSEEEETFDWSHGHLQVPLVIHWPGTPAQRINALTDHTDLMTTLMQRLLHVSTPASEYSQGQDLFNPQRRHYWVTAADNDTLAITTPKKTLVLNNNGKYRTYNLRGERVKDEKPQLSLLLQVLTDEKRFIAN
What are the official names of this protein?
Inner membrane protein YejM.
What is the protein family that this protein belongs to?
To H.influenzae HI_0842.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TMCAL_STAAS
Sequence: MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMALSTADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIEQSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKNAKNINAISIKRENAQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQIIAMTTDSLKNIYTVTEGFENRLKSNIYEATDFHHFVKLLKTKRYTYTHIQRLLMNVLLNIKPTDVTSNIHAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYNAISGQQQTDFNTPVIQQYR
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COS6_YEAST
Sequence: MKENELKNEKSVDVLSVKQLESQKTVLPQDLFRSSFTWFCYEIYKSLVFRIWMLLWLPLSVWWKLSNNWIYPLMVSLLVLFWGPVFVLVIFRLSRKRSLSKQLTQFCKEITKNTPSSDPHDWEVVAANLNSYFYENKAWNTKYFFFSAMSCQEAFRTTLLEPFSLKKDEAAKVKSFKDSVPYIEEALEVYFTEVEKQWKLFNSEKSWSPVGLEDAKLPKEAYRFKLTWVLKRIFNRRCLPLFLFYLHNVFISRNDGTIARPLFLVVLFFIMTRDFRNMRMIVLSVKMEHKMQFLSTIINEQESGANGWDEIAKKMNRYLFEKKVWKNEEFFFDGIDCEWFFSHFFYRVLSAKKSMRALSLNVELWPYIKEAQLSCSEESLA
What are the official names of this protein?
Protein COS6.
What is the protein family that this protein belongs to?
Belongs to the DUP/COS family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.