PharMolix/UniProtQA huggingface dataset:
Protein: MDM1_CHICK
Sequence: MPVRFRGLSEYKRNFRWKTPELCSPSQEQKSPWAGLRSDQLGITREPNFISKRRVPYHNPQISKSFEWTGDCDSDDPVETEALKTAESLAEHSNDVNQENTETPEGPRLPPKVRSHSSDSGVETALALAGNSMKKTPPVAPPNQKEAFVSPKKEAEKVNNGLHRVLQRKGGMNTPHLSTFPRNSEYQSQFVWKSPHEKSPILAAEEALYNTKREELIQKPAEDASKQEKSEQKHPKRKNKQHISQKPLSLHTHRGKMNTEYRSKFLSPAQYFYKDGAWSRIRSKVPNQASQNPLNSMWYMEVRELRARAKAYRQRIEGTHFSRYHLNQLLSDNNSLWDVSSNSSSEEGISNDIRALDLAGVSEKETAPRPKMLQQPGSREQSHQDDTEKKGLSDAPTVPVKRRLVWGEQEGTAEKDSQQLREEEEKENEQAAVVTQNLEKNNEGINEDNRIEGENTCLPNSPAAVSESSSVSSEPGGRLPTPKLRALGRAQRTHHDLTTPAVGGAVLVSPPKFKSSTSQQRMRSLGTDPSSVGQGAREASQRRSFRPGAKLKAVSLLTSPPAGLGTVDPLPLRQDQWHPNGVSGETVAINSAYQERSSTPPVLKSTKNRPMPCWSPSPRIQGTLKDPEFQHNGNVGNPKMGSFQLPLQERNYNNEDDRLSQISARSAASSSLASQILERAQKRKEDFWGKT
What is the function of this protein?
Microtubule-binding protein that negatively regulates centriole duplication.  Binds to and stabilizes microtubules.
What are the official names of this protein?
Nuclear protein MDM1.
What is the protein family that this protein belongs to?
Belongs to the MDM1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the centriole lumen.
Protein: RS12_CHLPD
Sequence: MPTIQQLIRSGRSIKASKTASPALEKCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNKIEVTAYIPGEGHNLQEHSIVLIRGGRVKDLPGVRYHIVRGSLDTSGVADRKQSRSKYGAKQPKAGAAAPVKGKRR
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: TR112_YEAST
Sequence: MKFLTTNFLKCSVKACDTSNDNFPLQYDGSKCQLVQDESIEFNPEFLLNIVDRVDWPAVLTVAAELGNNALPPTKPSFPSSIQELTDDDMAILNDLHTLLLQTSIAEGEMKCRNCGHIYYIKNGIPNLLLPPHLV
What is the function of this protein?
Acts as an activator of both rRNA/tRNA and protein methyltransferases.  Together with methyltransferase MTQ2, required for the methylation of eRF1 on 'Gln-182'.  Together with methyltransferase TRM11, required for the formation of 2-methylguanosine at position 10 (m2G10) in tRNA.  Together with methyltransferase BUD23, required for the formation of 7-methylguanine at position 1575 (m7G1575) in 18S rRNA.  Involved in biogenesis of both 40S and 60S ribosomal subunits.
What are the official names of this protein?
Multifunctional methyltransferase subunit TRM112, eRF1 methyltransferase subunit TRM112, eRF1 MTase subunit TRM112, tRNA methyltransferase 112.
What is the protein family that this protein belongs to?
Belongs to the TRM112 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BIOF_HAHCH
Sequence: MSKWGHLAQTLTARKQQDLYRSRLTIDSPQAPRVMIEGREYLAFCSNDYLGLANDPRLIAAAQQALSEFGLGGGASHLVIGHHRAHHELELDLAEFTGRDRALLFSTGYMANLGVASALLGRGDYVIEDKLNHASLLDAGMLSGARLLRYRHADAEHLALRLDEVGDSRALVITDGVFSMDGDIAPLDAIAQVCHSKDAMLMVDDAHGFGVLGTEGGGCAAHFQMNQVQVPVLMGTLGKSYGAAGAFVAGSGELIETLVQFARTYIYTTSMPPAIAAAARVSLRISREETWRRERLNELVTRFRKEAIGMGYQLAASSTPIQPVFIGDAAAAMELSQALRKEGILITAIRPPTVPANTSRLRVTFSAAHTDDDLNQLLEVLHKYRGATNIAGVANA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: SLX4_UNCRE
Sequence: MSFLNSSRRRTRSPSPGQIFAPSATPIVIDSSPSVPSASSILDSLLGEFSEARDPYTVEAGPTGRSSDHLFSSPGVLTQSPGRENVPPRPSERTKDAHGKDRFLVSTERNGRSPFRGNPYRSAEIHSPKGRLKAPTKEGGTRKTKKFSSSNRTLTGRSTKFLAKTASKPTQSSKVPSEIPAAKLDSLQWEDGELRLELATTRRGSWTPIKDTSIDIVDPTRNLSPSNVSAAGSQKFSSMLSDYGFTKGSTLTMENELRREVPTTKRRLELLQGTANDIFSEGDFSRPPEKSVVNPNGTHSRRSRKTTSTTITSLSTAQYGHQDSRQMSNLADFFPSGEAVERPSGAIKKLKTSKSGTKKKGVKKAKEAPLFKVASIEDALKSLEDQVCLFGTSSQLERVSSDEEPQMANFNLNAQFPRKNSRPQKTRSPCSNPKTSKSLWYASSRGYDDIEFVDMIDSSNPKTLESVEASTFVTPIDSSPMHSQVASQMVFENPCDVSHVLTKIPQTGPKDPIENPVCPEIQIRHSGNVKTQSTSGQSIPSFRGLTTAQLAQKVASFGFKPLRSREKMISLLEKCWESQQQTHIPAMLPASHTALPDSVTRAEQMSKRDTIKSRDIRASKSRSNSNHIPGLVSSTSQNTGYAAKSPDCIRGSSKSNDIGTTQGSPLLTTQSVIVIPDSDDSDNDNNPTGGAYSYPSLASNTPSSSTRTMASESLLSVRTRYEANVGEEQGSNDINQQITKAIRAQPRLVAINGVKRPTWLEKILMYDPIVLDDLTVWLNTEGLDQIGEDSEVSGTTVREWCESKGICCTWKKKRHVAP
What is the function of this protein?
Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX4.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPA_BACC7
Sequence: MGVEKMKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDGGVTLKGIFQALAEVRKEVQIPFVLMTYLNPVLAFGKEHFIERCLEAGVDGIIVPDLPYEEQDIIAPLLRTANIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKSHTNLPVVAGFGISTKEHVEEMITICDGVVVGSKIIELLENEKREEICEFIQATKQKEEA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: IFNG_MOSBE
Sequence: MKYTSYFLALQLCLLLGFSGSYGQGPFFKEIENLKEYFNASNPDVATGGPLFLEILKNWKEESDKKIIQSQIVSFYFKLFENFKDDQVIQRSMDIIKQDMFQKFLNGSSEKLEDFKKLIQIPVDDLQIQRKAINELIKVMNDLLPKSNLRKRKRSQNLFRGRRAST
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRG_METTH
Sequence: MVHLAKYIVVTGGVVSSIGKGITAASIGRILRSYGLSVTAIKIDPYLNWDSGTLNPYQHGEVFVTDDGMETDLDLGHYERFLDSDLPGEANITTGKVYMSVINKERSGDYLGSCVQIIPHITDEIKSMIRKIADKSGAEVVLVEVGGTVGDIEGQPFLEALRQLRNEEGHENVMFVHVTYVPYLRAAGEFKTKPTQHSTKELRSTGINPDMIICRSEMPIDSSLKRKIAHFCDVEEEAVVNAPDASSIYEVPLVLDSERVGDYIVRRIELDVDGEADLSEWAGIVESLMIDEPVVTVGIVGKYVELEDSYISIREALKHAAAHLRVRVDIEWISADDAVNEEDLSRLDSILIPGGFGERGIAGKLEAVRFALENRVPIFGICLGMQCMVIEFARLNGMEGANSTEFDPETPYPVIDMMEEQKRIKNMGGTMRLGSYQCRIREGTLAHEAYGTELVGERHRHRFELNNEFREELESKGLIISGTSPDDFLVEMVEIKDHPWFLGCQFHPEFRSRPNRAHPLFVSFLRAALERSR
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: SYT_YERPG
Sequence: MPVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAIITAKDAEGLEILRHSCAHLLGHAIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALLEKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILDENISRDDRPGLYHHEEYVDMCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYAEHMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSCIKMVYDMYSTFGFEKIVVKLSTRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPVQVVVMNITDSQSDYVQQVTKKLQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPB_CUPPJ
Sequence: MTSTPLPRLILGSSSPYRRELLERLRLTFEVAVPDINETPLAGESPEATALRLSLNKAQAIAQRHPDALIIGSDQVLTLDGRQMGKPGSHDKAREQLRLMRGRTATFHSALCLLDGRTGQSQLADVQTRVTMRDLTDAEIDAYLRLEKPYDVAGSAKSEGLGIALLSRVESDDPTALVGLPLIALTSMLRQSGYPFFAA
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF1_YEAS2
Sequence: MSTQFRKSNHNSHSSKKLNPALKSKIDTLTELFPDWTSDDLIDIVQEYDDLETIIDKITSGAVTRWDEVKKPAKKEKYEKKEQQHSYVPQQHLPNPEDDITYKSSNNSNSFTSTKHNSSNNYTQARNKKKVQTPRAHTTGKHVNLDKGKHVPSKPVSNTTSWAAAVSVDTKHDVPQDSNDNNNEELEAQGQQAQEKNQEKEQEEQQQQEGHNNKEEHKQIEQPSLSSKKTTSRTSASQPKKMSWAAIATPKPKAVKKTESPLENVAELKKEISDIKKDDQKSEASEEKVNEQETSAQEQEEETAEPSEENEDRVPEVDGEEVQEEAEEKEQVKEEEQTAEELEQEQDNVAAPEEEVTVVEEKVEISAVISEPPEDQANTVPQPQQQSQQPQQPQQPQQPQQPQQPQQQQQPQQPQQPQQQLQQQQQQQQQPVQAQAQAQEEQLSQNYYTQQQQQQYAQQQHQLQQQYLSQQQQYAQQQQQHPQPQSQQPQSQQSPQSQKQGNNVAAQQYYMYQNQFPGYSYPGMFDSQGYAYGQQYQQLAQNNAQTSGNANQYNFQQGYGQAGANTAAANLTSAAAAAAASPATAHAQPQQQQPYGGSFMPYYAHFYQQSFPYGQPQYGVAGQYPYQLPKNNYNYYQTQNGQEQQSPNQGVAQHSEDSQQKQSQQQQQQQPQGQPQPEVQMQNGQPVNPQQQMQFQQYYQFQQQQQQAAAAAAAAAQQGVPYGYNGYDYNSKNSRGFY
What is the function of this protein?
Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II.  Also involved in telomere length regulation.  Binds DNA.
What are the official names of this protein?
RNA polymerase II degradation factor 1, RRM3-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEF1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: SYI_XYLFM
Sequence: MSQDYKTTLHLPATDFPMRGDLPKREPAILERWERDDFYAQLRAHAKGRPLFLLHDGPPYANGQIHLGHAVNKILKDIIIKSKHLDGFDAPYIPGWDCHGLPIEIAIEKKYGKVGVTLDAVQFRQKCREYAAEQIQLQRRDFKRLGVIGDWDAPYKTLDFRFEADEIRALAKIVDKGHLIRGTKPVHWCFDCGSALAEAEIEYTDKTSPMVDVAYPALDPSALAAVFNATLPPDVQLAVPIWTTTPWTLPASLAISVGPTLDYVLVEGPTHSGQRRWLILAEALAAKALARYGIAELLIHGSAKGAAMEQHILAHPFYPDRTIPLLLGNHVSAEDGTGAVHTAPGHGQEDHQVFQQYGLLNRYSAAELNPVDARGVYLSTTPPLGELTLAGLHIWKANPLIVDALRLRGVLLAAAEMHHSYPHCWRHKTPIVFRATPQWFISMEQAALRSAALKAITHVTWYPQWGQARILSMIENRPDWTISRQRTWGVPIPLFVHRHSGAPHPRSAALMRQIADRVEQQGVDIWYSLDQTELLGTEADQYEKITDILDVWFDSGITHEAVLLERGLPKPADLYLEGADQHRGWFQSSLLTGVAMDNAAPYKQCLTHGFTVDQHGRKMSKSLGNGIEPQDIIKTLGADILRLWIASTDYSNEMSLSQEILKRTTDAYRRIRNTTRFLLGNLHGFDPTLHLVPLSDMIALDRWIVHRAFELQQTIKAAYTRYDFAEIIQKILNFCSVDLGSLYLDVTKDRLYTMHENAPGRRSAQTAMYHLTAAFVRWIAPILSFTADELWSYLPGDHADNVLFTTWYDGLAPLPPNAPLTAADFDKLLTLRDHVTKVLEPMRANGVIGAALEAEITVAADADTAARWQPLTEELRFLFITGDVTVTPANTDGFFVSAQATTKAKCARCWHYRADIGAHPTHPELCGRCITNVDGPGEQRHWF
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_SALEP
Sequence: MSAIAPGMILFAYLCGSISSAILVCRIAGLPDPRESGSGNPGATNVLRIGGKGAAVAVLIFDILKGMLPVWGAYALGVTPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKLKKKRQKD
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KEFB_ECOLI
Sequence: MEGSDFLLAGVLFLFAAVAAVPLASRLGIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKLWQLRRSIFGVGAAQVLLSAALLAGLLMLTDFAWQAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDLAVIPALALVPLLAGSADEHFDWMKVGMKVLAFVGMLIGGRYLLRPVFRFIAASGVREVFTAATLLLVLGSALFMDALGLSMALGTFIAGVLLAESEYRHELETAIDPFKGLLLGLFFISVGMSLNLGVLYTHLLWVVISVVVLVAVKILVLYLLARLYGVRSSERMQFAGVLSQGGEFAFVLFSTASSQRLFQGDQMALLLVTVTLSMMTTPLLMKLVDKWLSRQFNGPEEEDEKPWVNDDKPQVIVVGFGRFGQVIGRLLMANKMRITVLERDISAVNLMRKYGYKVYYGDATQVDLLRSAGAEAAESIVITCNEPEDTMKLVEICQQHFPHLHILARARGRVEAHELLQAGVTQFSRETFSSALELGRKTLVTLGMHPHQAQRAQLHFRRLDMRMLRELIPMHADTVQISRAREARRELEEIFQREMQQERRQLDGWDEFE
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefB, K(+)/H(+) antiporter, NEM-activable K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KTHY_SYMTH
Sequence: MSVFISFEGVDGSGKSTQIRLLLQYLDEQSVPYVFTREPGGTPIAEQIRRVLLDPANRGMSVITEALLFAAARAEHVSRTIRPALEEGKVVICDRFVDSSLVYQGVAGGLPVEFLTQINEMATGALRPHRTIVLDLAPEVALARRTGEEADRIERQSREYHQLVREGYLDLARAEPRRVKVVDASRSVEEVQKDIRRLVEEVLPRRFRGAGTRP
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: MATK_PLAOC
Sequence: MEELQGYLEIDRSRQQDFLYPLLFQEYIYALAHDHSLNRSILYEPMENLGYDNKSSSLIVKRFITRMYQQNHLIISANDSNQNKFVGHNKNLDSQTISEGFAIIVEIPFSLRLVSSLEGLEGKGKEIVKSRNLRSIHSIFSFLEDKLSHLNYVSDILIPHPIHPEILVQVLRSWVQDAPSLHLLRLFLHEYRNWTSLITPKKSISIFSKENQRFFLFLYNFHICECESIFVFLRKQSSHLRSTSFRALLERTHFYGKMEHFVVVFRNNFQTILWLVKDPFMHYVRYQGKSFLASKGTPLLMNKWKYYLVNFWQYYFYLWSQPSRIHINQLSNHSLDFLGYLSSVRLNPSVVSSQMLENLYLMDIAIKKFDTIIPIIPLIGSLAKAKFCNVSGHPVSKPVRADSSDSDIIDRFGRICKNLSHYHSGSSKKKSLYRIKYILRLSCARTLARKHKSTVRAFLKRLGSELLEEFFTEEEQVLSLIFPRTSSPSRRLYRKQIWYLDIIRINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NDUS1_NEUCR
Sequence: MLRSTLSRSAWRTGRHQAARNASRAFSATAQRPAEVELTIDGKKVSIEAGSALIQACEKAGVTIPRYCYHEKLMIAGNCRMCLVEVEKVPKPVASCAWPVQPGMVVKTNSPLTHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGGDRGRFHEVGGKRAVEDKNMGPLIKTSMNRCIQCTRCVRFANDIAGAPELGSTGRGNDLQIGTYLEKNLDSELSGNVIDLCPVGALTSKPYAFRARPWELKKTESIDVLDGLGSNIRVDTRGLEVMRILPRLNDEVNEEWINDKTRFACDGLKTQRLTIPLVRREGKFEPASWDQALTEIAHAYQTLNPQGNEFKAIAGQLTEVESLVAMKDLANRLGSENLALDMPSGHKPLAHGVDVRSNYIFNSSIVGIESADVILLVGTNPRHEAAVLNARIRKQWLRSDLEIGVVGQTWDSTFEFEHLGTDHAALQKALEGDFGKKLQSAKNPMIIVGSGVTDHGDANAFYETVGKFVDSNASNFLTEEWNGYNVLQRAASRVGAFEVGFTVPSAEIAQTKPKFVWLLGADEFNEADIPKDAFIVYQGHHGDRGAQIADIVLPGAAYTEKAGTYVNTEGRVQMTRAATGLPGAARTDWKILRAVSEYLGVRLPYDDVAQLRDRMVEISPALSSYDIIEPPSLQQLSKVQLVEQNQGATATNEPLKKVIENFYFTDAISRSSPTMARCSAAKKTGDPRTNFMAPGMEEDRPMGQIAYGA
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.  This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme.  It may form part of the active site crevice where NADH is oxidized.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial, Complex I-78kD, CI-78kD.
What is the protein family that this protein belongs to?
Belongs to the complex I 75 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: RSMH_SALAR
Sequence: MMENFKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAQAINDPRFSIIHGPFSALADYVAERELTGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLQTAEEADIAWVLKTFGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLSVLAPGGRLSIISFHSLEDRIVKRFMREQSRGPQVPAGLPMTEAQLKKLGGRELRVLGKLMPGEKEVAENPRARSSVLRIAERTNA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCNH_BOVIN
Sequence: MYHNSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPNDPVFLEPHEEITLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKTLEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPLLENPEILRKTADDFLNRVALTDAHLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTSLSQLLDIMKSMRNLVKKYEPPRPEEVAALKQKLERCHSAELALNVVTKKRKGYEDDDYVSKKSKHEEVCSPKGSFM
What is the function of this protein?
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex.  CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation.  CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts.  Involved in cell cycle control and in RNA transcription by RNA polymerase II.  Its expression and activity are constant throughout the cell cycle (By similarity).
What are the official names of this protein?
Cyclin-H.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: KCNKI_MOUSE
Sequence: MEAEEPPEARRCCPEALGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFSAVEGRPDPEAEENPELKKFLDDLCNILKCNLTVVEGSRKNLCEHLQHLKPQWLKAPQDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILATILSRAYSRFQALLCLPHDIFKWRSLPLCRKQPDSKPVEEAIPQIVIDAGVDELLNPQPSKDPPSPSCNVELFERLVAREKKNKLQPPTRPVERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVVFAYISCAAAILPFWETELGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYKTLMLFVCQREVSLPW
What is the function of this protein?
Outward rectifying potassium channel.  Produces rapidly activating outward rectifier K(+) currents.  May function as background potassium channel that sets the resting membrane potential.  Channel activity is directly activated by calcium signal.  Activated by the G(q)-protein coupled receptor pathway.  The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation.  Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids.  Channel activity is also enhanced by volatile anesthetics, such as isoflurane.  Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper.  May be involved in the somatosensory function with special respect to pain sensation.
What are the official names of this protein?
Potassium channel subfamily K member 18, Two-pore-domain potassium channel TRESK.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DGAF_SALT1
Sequence: MQQINFYRQRVAINVLAKDIANAKAIYEAAEGHAVIGVLSAQFATVEEGVPEVKRWMAEVPSISVGLGAGDPAQYYKAAMIAAHTHPAHVNQTFTGSGFAAGALAATGGEQTHINALVSPTGTPGEVVISTGVSSSQGTPARVSCEAAVRMMQDMGAHAAKFFPMGGEKSLPELYALATTAARHGMTLIEPTGGISLDNFGIILQTCLEAGVPRVMPHVYSSIIDPQTGNTRPEDIIRLMEIVKALV
What is the function of this protein?
Involved in the catabolism of D-glucosaminate.  Catalyzes the conversion of keto-3-deoxygluconate 6-phosphate (KDGP) to yield pyruvate and glyceraldehyde-3-phosphate.
What are the official names of this protein?
2-dehydro-3-deoxy-phosphogluconate aldolase, Keto-3-deoxygluconate 6-phosphate aldolase, KDGP aldolase.
What is the protein family that this protein belongs to?
Belongs to the DagF family.