PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_ACIBY
Sequence: MAITSVIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPELVQADSPTTKVGGQALSKFESVTHVVPMLSLGNVFNQEDLFAFARRVEERLPNQKVQYEVELKLDGLAISLWYENGVLVRGVTRGDGETGEDITQNVKTIRNLPKVLHSEKYEIPRLLEVRGEVLMPKSGFEKLNADQEAKGEKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPNHGLTTMHDSLQWLTELGFQIAERQYLCNSIQEVQQRYEQIQQERPNLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQAALTTVEQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRIGDTVSVYRTGDVIPKVEKVWPEFRPAEAEVVHLPESCPVCASPVVMPEGEALARCSGGLYCAAQRIEAIRHFVSRKAMDIEGLGDRWVESLLRLDLLKDVADIYHLHEHRETLLGIEKMGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAANVEALKKTPDVGDITAEWIADFFLAPHNIEVLDRLIAAGIHWDAPTAPTRQPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCVVAGEKAGSKLEKAAKLGIPVMNETDFLSLMAGYGQTLS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DIAA_SALPB
Sequence: MLERIKVCFTESIQTQIAAAEALPDAISRAAMTLVHSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHHSARIQEMHMLTVNCLCDLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: VP5_EHDV1
Sequence: MGKFIKQLSKFGKKVGGALTSNTAKKIYKTIGDTAVRFAESDIGSAAIDGLIQGSVESVLTGESYGETVKRAVLLNVLGAGDEIPDPLSPGEQGIQRKIKELEDEMKGEVVRTKHNEQIIRRFGADLDEVYKFAVSEYKEGVEEKDQFEILKKALTSYGELTKAEFGELKRLEKALQKESSERSKDESMMVKEYRQKIEALKDAIEVESTGIQEEAIQEIAGMSADILESAAEEVPLFGGGVATSIATARAIEGGYKLKKVINALSGIDLSHLRTPKIQPKTLEAILEAPTKEEIKDLSLVEGIQMKLQNLEENRNEVLHIQEEILPKLREAMIEDHKEIGDERDKRILPKTAMRFKVPTTQQPVIQIYSAPWDSDDVFMFHCISHHHLNESSFLGFDLELEYVHYEDLTRHWHALGAAQEVTGRSLKEAYSEFFQLAAQIDGAGAIHQKRLIRSKSYHPIYLGAMHYDIAYRELKNNALKIVNDSEVQKHLLRGPKHFQRRAILSALKDGVKLLGGVDLAEFMRYA
What is the function of this protein?
VP5 protein is one of the two proteins (with VP2) which constitute the virus particle outer capsid.  Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm.  Permeabilization activity is probably negatively regulated by VP2 and is triggered by endosomal degradation of VP2 and exposure to low pH (By similarity).
What are the official names of this protein?
Outer capsid protein VP5.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP5 family.
What are the subcellular locations of this protein?
Virion.
Protein: ARBG_DICCH
Sequence: MKIAKILNNNVVTVMDEQNNEQVVMGRGLGFKKRPGDTVNAALIEKIFSLRSSELTARLSDVLERIPLEVVTTADRIIALAKEKLGGNLQNSLYISLTDHCHFAIERHRQGVDIRNGLQWEVKRLYQKEFAIGLDALDIIHRRLGVRLPEDEAGFIALHLVNAQLDSHMPEVMRITRVMQEILNIVKYQLNLDYNEQAFSYHRFVTHLKFFAQRLLGRTPVFSEDESLHDVVKEKYTLAYHCAEKIQDHIMLHYDYTLTKEELMFLAIHIERVRSELQEQTAE
What is the function of this protein?
Mediates the positive regulation of the beta-glucoside (arb) operon by functioning as a transcriptional antiterminator.  This is an RNA-binding protein that recognizes a specific sequence located just upstream of two termination sites within the operon (By similarity).
What are the official names of this protein?
Beta-glucoside operon antiterminator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional antiterminator BglG family.
Protein: GCH4_PSEAE
Sequence: MNALTLPDIARQTTTADLPLDWVGMQGIALPVQIGGQRVAAEADAGVSLDDPQARGIHMSRLYLALAELEQGELDLSCLRAVLQRFLDSHAGLSRRAYLRLRLAPLLRRPALVSPLSGWKRYPLVLDTRLEGDDFQAEVHLELTYSSTCPCSAALARQLIQERFDQDFAGQPLDHASVLAWLGSSAGIVATPHSQRSSAHLRIGLAEDCIGLPLEELADLGESALGTAVQTAVKRADEQAFALANGQNLMFCEDAVRRLHRALQGYPQASRFSIRVVHAESLHAHDAVAESHWQRGAA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: F16P1_ORYSJ
Sequence: MAAAATTSSHLLLLSRQQAAASLQCGLSFRRQPGRLAGGSSAPSVRCMAAVDTASAPAATEASKKSSYEITTLTTWLLKQEQAGTIDGEMTIVLASISTACKQIASLVQRAPISNLTGVQGAVNVQGEDQKKLDVVSNEVFSNCLKSSGRTGVIASEEEDVPVAVEESYSGNYIVVFDPLDGSSNIDAAVSTGSIFGIYSPNDECLADIADDQNLDQVEQRCIVSVCQPGSNLLAAGYCMYSSSVIFVLTIGTGVYVFTLDPMYGEFVLTQEKVQIPKAGKIYAFNEGNYALWDDKLKSYMDSLKEPGPSGKPYSARYIGSLVGDFHRTLLYGGIYGYPRDQKSKNGKLRLLYECAPMSFIVEQAGGKGSDGHQRILDIMPTEIHQRVPLYIGSVEEVEKVEKFLA
What is the function of this protein?
Catalyzes the irreversible reaction from fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate, to regenerate the primary CO(2) acceptor molecule, ribulose-1,5-bisphosphate.  Involved in the regulation of photosynthetic performance and sucrose synthesis.
What are the official names of this protein?
Fructose-1,6-bisphosphatase, chloroplastic, FBPase, D-fructose-1,6-bisphosphate 1-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: OSGP2_ARATH
Sequence: MVRLFLTLSPAISRFNLYPGISILARNNNSLRLQKHHKLKTKTPTFSLISPSSSPNFQRTRFYSTETRISSLPYSENPNFDDNLVVLGIETSCDDTAAAVVRGNGEILSQVISSQAELLVQYGGVAPKQAEEAHSRVIDKVVQDALDKANLTEKDLSAVAVTIGPGLSLCLRVGVRKARRVAGNFSLPIVGVHHMEAHALVARLVEQELSFPFMALLISGGHNLLVLAHKLGQYTQLGTTVDDAIGEAFDKTAKWLGLDMHRSGGPAVEELALEGDAKSVKFNVPMKYHKDCNFSYAGLKTQVRLAIEAKEIDAKCPVSSATNEDRRNRADIAASFQRVAVLHLEEKCERAIDWALELEPSIKHMVISGGVASNKYVRLRLNNIVENKNLKLVCPPPSLCTDNGVMVAWTGLEHFRVGRYDPPPPATEPEDYVYDLRPRWPLGEEYAKGRSEARSMRTARIHPSLTSIIRADSLQQQTQT
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine.  Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Involved in mitochondrial genome maintenance (By similarity).  May have a role in embryonic development in plants.
What are the official names of this protein?
Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial, Glycoprotease 1, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein GCP1, tRNA threonylcarbamoyladenosine biosynthesis protein GCP1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: XPT_STUS1
Sequence: MEQLKDKIRSHGIVLSDRVLKVDAFLNHQIDPVLMQAIGREFARRFRDDGITKIVTIEASGIAPAVMAGLELGVPVIFARKHQSLTLHDNLLTATVYSFTKQVESTIAVSTQHLSANDRVLIIDDFLANGKAAKGLISIINQAGASIAGLGIVIEKSFQTGRKELEEAGYRVESLARVASLADGAVQFID
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
Protein: NSG1_RAT
Sequence: MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPKIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYTEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA
What is the function of this protein?
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:18299352, PubMed:15911354).  Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (PubMed:15911354).  Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (PubMed:18299352).  In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).
What are the official names of this protein?
Neuronal vesicle trafficking-associated protein 1, Brain neuron cytoplasmic protein 1/2, Neuron-enriched endosomal protein of 21 kDa, Neuron-specific protein family member 1.
What is the protein family that this protein belongs to?
Belongs to the NSG family.
What are the subcellular locations of this protein?
Membrane; Single- pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Cell projection, dendrite. Early endosome membrane. Late endosome membrane. Lysosome lumen. Recycling endosome membrane. Cytoplasmic vesicle membrane. Golgi apparatus, Golgi stack membrane. Endosome, multivesicular body membrane. Endoplasmic reticulum membrane. Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (PubMed:28874679). Endoplasmic reticulum targeting is essential for apoptosis (By similarity). Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity).
Protein: MMAC_HUMAN
Sequence: MEPKVAELKQKIEDTLCPFGFEVYPFQVAWYNELLPPAFHLPLPGPTLAFLVLSTPAMFDRALKPFLQSCHLRMLTDPVDQCVAYHLGRVRESLPELQIEIIADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVEADPWGNQRISGVCIHPRFGGWFAIRGVVLLPGIEVPDLPPRKPHDCVPTRADRIALLEGFNFHWRDWTYRDAVTPQERYSEEQKAYFSTPPAQRLALLGLAQPSEKPSSPSPDLPFTTPAPKKPGNPSRARSWLSPRVSPPASPGP
What is the function of this protein?
Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485).  Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555).  Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791).  The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510).  Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485).  The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555).  Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555).
What are the official names of this protein?
Cyanocobalamin reductase / alkylcobalamin dealkylase, Alkylcobalamin:glutathione S-alkyltransferase, CblC, Cyanocobalamin reductase (cyanide-eliminating), Methylmalonic aciduria and homocystinuria type C protein, MMACHC.
What is the protein family that this protein belongs to?
Belongs to the MMACHC family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: FOLD_PROMM
Sequence: MALRLDGKQLAAELEQRLQAEIAAGLVQAGRPPGLAVLRIGDDPASGVYVANKQKACGRIGVASHLTHLPETVSVSKVLATIQALNIDERVDGILLQLPLPKGLDEGPLLAAIDPEKDADGLHTLNLGRLLKGEPGPRSCTPAGVMALLARHQISLERKRAVVIGRSILVGQPMALMLQAANATVSVAHSHTGDLASLTQQADVLVVAAGRARMIGAEHVKPGAVVVDVGIHRLPLDPELGTQAKARLCGDVRTQEVEPLASALTPVPGGVGPMTVTMLLVNTVARWQQHCGLPFGLRDLLV
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: FARS_ZEAMH
Sequence: MDATAFHPSLWGDFFVKYKPPTAPKRGHMTERAELLKEEVRKTLKAAANQIKNALDLIITLQRLGLDHHYENEISELLRFVYSSSDYDDKDLYVVSLRFYLLRKHGHCVSSDVFTSFKDEEGNFVVDDTKCLLSLYNAAYFRTHGEKVLDEAIAFTRRQLEASLLDPLEPALADEVHLTLQTPLFRRLRILEAINYIPIYGKEAGRNEAILELAKLNFNLAQLIYCGELKEVTLWWKQLNVETNLSFIRDRIVECHFWMTGACCEPQYSLSRVIATKMTALITVLDDMMDTYSTTEEAMLLAEAIYRWEENAAELLPGYMKDFYLYLLKTIDSCGDELGPNRSFRTFYLKEMLKVLVRGSSQEIKWRNENYVPKTISEHLEHSGPTVGAFQVACSSFVGMGDIITKESFEWLLTYPELVKSLMNIARLLNDTASTKREQNAGQHVSTVQCYMLKHGTTMDEACEKVKELTEDSWKDMMELYLTPTEHPKLIAQTIVDFARTADYMYKETDGFTFSHTIKDMIAKLFVDPISLF
What is the function of this protein?
Sesquiterpene cyclase catalyzing the production of beta-farnesene and alpha-bergamotene in equal amounts from farnesyl diphosphate.  Involved in indirect defense by producing volatile signals attracting natural enemies of herbivores.
What are the official names of this protein?
(E)-beta-farnesene synthase, Terpene synthase 10.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_STAAR
Sequence: MTMTDPIADMLTRVRNANMVRHEKLELPASNIKKEIAEILKSEGFIKNVEYVEDDKQGVLRLFLKYGQNDERVITGLKRISKPGLRVYAKASEMPKVLNGLGIALVSTSEGVITDKEARKRNVGGEIIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: IF1_BUCAI
Sequence: MSKEENIEMQGVVIDTLPNTMFRVELENKHIVTAHISGKMRKNYIRILTGDKVTVELTPYDLTKGRIIFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIF3B_MOUSE
Sequence: MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTSHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEDGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYTSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKNKIMNRSFFDDEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEPRYRAENIMLLELDMPSRTTRDYEGPAISPKVQAALDAALQDEDEIQVDASSFESTASRKPKARPKSGRKSGSSSSSSGNPASQFYPQSRGLVPK
What is the function of this protein?
Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes.  Uses ATP hydrolysis to generate force to bind and move along the microtubule (PubMed:7559760).  Plays a role in cilia formation (PubMed:9865700).  Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (By similarity).  Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (PubMed:31746486).
What are the official names of this protein?
Kinesin-like protein KIF3B, Microtubule plus end-directed kinesin motor 3B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium. Cell projection, dendritic spine. Note=Colocalized with GRIN2A in dendritic shafts and in DLG4-positive spines.
Protein: NEF_HV2EH
Sequence: MGSAGSKKQSKQQPGLRERLLRARRGPRGESSGERQERSLQYPGGSDKGLNSPSCDGQKTLGAEGGGKQDSDEDDEDNEVGVRVRPGVPLRPMTFKLAVDMSHFLKEKGELEGIFYSERRHKILDTYLENEEGIVSGWQNYTHGPGVRYPKFFGWLWKLVPINMIAEPEDEETHCLVHPAQTSAWDDPHEETLVWQFDSLLAYDYVAFSRFPEEFGYQSGMPEKEWKAKLRARGIPTE
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Associates with the inner plasma membrane through its N-terminal domain.
Protein: TRMA_VIBC1
Sequence: MATLDVNPQRYQEQLAEKVERLNDMFAPYNVPELEVFESPEQHYRMRAEFRVWHEGEDLYYIMFNQETREKYRVDQFPAASRLINDLMPLLVEAMKDNESLRRKLFQVDFLSTLSGEILVSLLYHRQLDEEWIENAKALKQRLNDEGFNLNIIGRARKMKIVLDRDYVIEKLDVNGQSYIYQQVENSFTQPNGKVAEKMLEWAVDCTQESTGDLLELYCGNGNFSLALAQNFDRVLATELAKPSVVSAQYNIAANEIDNVQILRLSAEEFTQAIEGKREFRRLQDAGVDLKSYNCNTIFVDPPRSGMDVDTCKMVQGYERIMYISCNPETLKENLDILCETHNVTRFALFDQFPYTHHMEAGVLLERKA
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: TO6BL_YEAST
Sequence: MARDITFLTVFLESCGAVNNDEAGKLLSAWTSTVRIEGPESTDSNSLYIPLLPPGMLKIKLNFKMNDRLVTEEQELFTKLREIVGSSIRFWEEQLFYQVQDVSTIENHVILSLKCTILTDAQISTFISKPRELHTHAKGYPEIYYLSELSTTVNFFSKEGNYVEISQVIPHFNEYFSSLIVSQLEFEYPMVFSMISRLRLKWQQSSLAPISYALTSNSVLLPIMLNMIAQDKSSTTAYQILCRRRGPPIQNFQIFSLPAVTYNK
What is the function of this protein?
Required for formation of the SPO11-mediated double-strand breaks (DSBs) that initiate meiotic recombination.  May mediate the interaction between SPO11 subunits during meiosis.  Also needed for homolog chromosome pairing, synaptonemal complex formation, and for the proper timing of the first meiotic division.  Not required for mitosis and mitotic DNA repair mechanisms.
What are the official names of this protein?
Meiotic recombination protein REC102.
What is the protein family that this protein belongs to?
Belongs to the TOP6B-like family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with chromatin during prophase. Recruitment to chromatin depends on REC104, SPO11 and SKI8.
Protein: UTF1_MOUSE
Sequence: MLLRPRRLPAFSPPSPASPDAELRSAGDVPVTTSDAFATSGGMAEPGSPKAPVSPDSAQRTPWSARETELLLGTLLQPAMWRSLLLDRRQTLPTYRRVSAALARQQVRRTPAQCRRRYKFLKDKLRDSQGQPSGPFDNQIRQLMGLLGDDGPPRVRRRSTGPGRPQRRGRSSLSALAPAPAPVEQEAELPLAAENDEPAPALRFSSSTTKSAGAHRITSSPPLTSTDTLPPEPGHTFESSPTPTPDHDVETPNEPPGLSQGRASSPQVAPQSLNTALLQTLTHLGDISTVLGPLRDQLSTLNQHVEHLRGSFDQTVSLAVGFILGSAASERGILGDLRQ
What is the function of this protein?
Acts as a transcriptional coactivator of ATF2.
What are the official names of this protein?
Undifferentiated embryonic cell transcription factor 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: SMR2C_MOUSE
Sequence: MKALYMVFVLWVLIGCFLSSECQRGFRGQHDPTRPLSPSNPSSHFYPQPDPNRVQISQPDNIPIFMFEQPHSLNICVPPPPLYLGEEFEKLPPNTHIPYILIRPDIEPPSKYIQPVPRKKSNATPAANNFITTATAPNSTDSF
What is the function of this protein?
May play a role in protection or detoxification.
What are the official names of this protein?
Submaxillary gland androgen-regulated protein 2, isoform gamma, Salivary protein MSG2, isoform gamma.
What are the subcellular locations of this protein?
Secreted.
Protein: SOTB_ECOHS
Sequence: MTTNTVSRKVAWLRVVTLAVAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGIMLTIYAWVVALMSLPFMLMTSQVERRKLLICLFVVFIASHVLSFLSWSFTVLVISRIGVAFAHAIFWSITASLAIRMAPAGKRAQALSLIATGTALAMVLGLPLGRIVGQYFGWRMTFFAIGIGALITLLCLIKLLPLLPSEHSGSLKSLPLLFRRPALMSIYLLTVVVVTAHYTAYSYIEPFVQNIAGFSANFATALLLLLGGAGIIGSVIFGKLGNQYASALVSTAIALLLVCLALLLPAANSEIHLGVLSIFWGIAMMIIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSMIGYVGAVPAFAALIWSIIIFRRWPVTLEEQTQ
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PLDA1_MAIZE
Sequence: MAQILLHGTLHATIFEAESLSNPHRATGGAPKFIRKLVEGIEDTVGVGKGATKIYATVDLEKARVGRTRMISNEPVNPRWYESFHIYCAHMAADVIFTVKIDNSIGASLIGRAYLAVQDLLGGEEIDKWLEISDENREPVGDSKIHVKLQYFDVGKDRNWARGVRSTKYPGVPYTFFSQRQGCKVTLYQDAHVPDNFVPRIQLADGKNYEPHRCWEDIFDAISKAQHLIYITGWSVYTEITLVRDTNRPKPGGDVTLGELLKRKASEGVRVLMLVWDDRTSVGLLKKDGLMATHDEETANYFHGTDVNCVLCPRNPDDSGSFVQDLQISTMFTHHQKIVVVDHEMPNQGSQQRRIVSFIGGIDLCDGRYDTQYHSLFRTLDTVHHDDFHQPNFEGGSIKKGGPREPWHDIHSRLEGPIAWDVLYNFEQRWRKQGGKDLLVRLRDLPDIIIPPSPVMFPEDRETWNVQLFRSIDGGAAFGFPETPEEAARAGLVSGKDQIIDRSIQDAYVNAIRRAKNFIYIENQYFLGSSYGWKPEGIKPEEIGALHLIPKELSLKIVSKIEAGERFTVYVVVPMWPEGVPESASVQAILDWQRRTMEMMYTDIAQALEANGIEANPKDYLTFFCLGNREVKQEGEYEPEEHPEPDTDYIRAQEARRFMIYVHTKMMIVDDEYIIIGSANINQRSMDGARDSEIAMGAYQPYHLATRQPARGQIHGFRMSLWYEHLGMLEDVFQRPESVECVQKVNEVAEKYWDLYSSDDLEQDLPGHLLSYPIGVTADGSVTELPGMENFPDTRARVLGNKSDYLPPILTT
What is the function of this protein?
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.  Plays an important role in various cellular processes.
What are the official names of this protein?
Phospholipase D alpha 1, PLD alpha 1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D 1.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. C2-PLD subfamily.
Protein: PSAC_CHAVU
Sequence: MSHKIKIYDTCIGCTQCVRACPTDVLEMIPWQGCKAKQIASAPRTEDCVGCKRCESACPTDFLSVRVYLGSETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.