PharMolix/UniProtQA huggingface dataset:
Protein: CTAX_CONMR
Sequence: MRCLPVLIILLLLTASAPGVDVLPKTEDDVPLSSVYGNGKSILRGILRKGICCGVSFCYPC
What is the function of this protein?
Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2) (By similarity).  Induces flaccid paralysis, when injected intra-cerebroventricularly into mice.
What are the official names of this protein?
Chi-conotoxin CMrX, Conotoxin CMrX, Conotoxin Mr1.6, Lambda-conotoxin CMrX.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARAB_STAAS
Sequence: MSYSIGIDYGTASGRVFLINTTNGQVVSKFVKPYTHGVIESELNGLKIPHTYALQNSNDYLEIMEEGISYIVRESKIDPDNIVGIGIDFTSSTIIFTDENLNPVHNLKQFKNNPHAYVKLWKHHGAYKEAEKLYQTAIENNNKWLGHYGYNVSSEWMIPKIMEVMNRAPEIMEKTAYIMEAGDWIVNKLTNKNIRSNCGLGFKAFWEEETGFHYDLFDKIDPKLSKVIQDKVSAPVVNIGEAVGKLDDKMAQKLGLSKETMVSPFIIDAHASLLGIGSEKDKEMTMVMGTSTCHLMLNEKQHQVPGISGSVKGAIIPELFAYEAGQSAVGDLFEYVAKQAPKSYVDEAANRNMTVFELMNEKIKHQMPGESGLIALDWHNGNRSVLSDSNLTGCIFGLTLQTKHEDIYRAYLEATAFGTKMIMQQYQDWHMEVEKVFACGGIPKKNAVMMDIYANVLNKKLIVMDSEYAPAIGAAILGAVSGGAHNSINDAVDAMKEPILYEINPEAEKVQRYETLFKAYKALHDIHGYKKANIMKDIQSLRVEG
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: RPO1C_THEVO
Sequence: MIIWKDTAKNMSLLSKSVPAKYAVDFEVPKGITEGYVTSDKKRFTYHVSISSVAPYSNESDVIQKKKSGLKSIMEIEKIQKIEPISIMEFRSSGKRIDELLTYAIAERETAEIREKYEYEKKVSSQVLDVIAEAKKLGYNIPESVAEEILRRKEEWGEKKYREILKRIGEEIQDELIDPYEAVGIIAAQSIGEPGTQMTMRTFHFAGVREMNVTLGLPRLIEIVDARRIPSTPSMTIYLKPEFETNDEVVMDVVKRLENTSVSDVADIITDIGELTITVRPDPNKMNDRLINQDDLVNAIYKVKGVTVMEESGQIIVKPQQESFKKLYLLQEQIKALPIKGISGIKRAIARVEGKEHRWVIYTQGSNLKDVLEVDEVDPTRTYTNDIVEIATVLGIEAARNAILNEAQRTLQEQGLNVDVRHLMLVADMMTFSGSVRAVGRTGISGRKSSVLARAAFEITTKHLLRAGIMGEVDKLAGVAENIIVGQPITLGTGAVDIIYKGYPKTKK
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSP_BACTN
Sequence: MKTDLLASRHIGINEEDTAVMLRKIGVDSLDELINKTIPANIRLKEPLALAKPLTEYEFGKHIADLASKNKLYTTYIGLGWYNTITPAVIQRNVFENPVWYTSYTPYQTEVSQGRLEALMNFQTAVCDLTAMPLANCSLLDEATAAAEAVTMMYALRSRTQQKAGANVVFVDENIFPQTLAVMTTRAIPQGIELRVGKYKEFEPSPEIFACILQYPNSSGNVEDYADFTKKAHEADCKVAVAADILSLALLTPPGEWGADIVFGTTQRLGTPMFYGGPSAGYFATRDEYKRNMPGRIIGWSKDKYGKLCYRMALQTREQHIKREKATSNICTAQALLATMAGFYAVYHGQEGIKTIASRIHSITVFLDKQLKKFGYTQVNAQYFDTLRFELPEHVSAQQIRTIALSKEVNLRYYENGDVGFSIDETTDIAATNVLLSIFAIAAGKDYQKVEDVPEKSNIDKALKRTTPFLTHEVFSNYHTETEMMRYIKRLDRKDISLAQSMISLGSCTMKLNAAAEMLPLSRPEFMSMHPLVPEDQAEGYRELISNLSEDLKVITGFAGVSLQPNSGAAGEYAGLRVIRAYLESIGQGHRNKILIPASAHGTNPASAIQAGFETVTCACDEQGNVDMGDLRAKAEENKEALAALMITYPSTHGIFETEIKEICEIIHACGAQVYMDGANMNAQVGLTNPGFIGADVCHLNLHKTFASPHGGGGPGVGPICVAEHLVPFLPGHSIFGSTQNQVSAAPFGSAGILPITYGYIRMMGTEGLTQATKIAILNANYLAACLKDTYGIVYRGATGFVGHEMILECRKVHEETGISENDIAKRLMDYGYHAPTLSFPVHGTLMIEPTESESLAELDNFVDVMLNIWKEIQEVKNEEADKNDNVLINAPHPEYEIVNDNWEHSYTREKAAYPIESVRENKFWVNVARVDNTLGDRKLLPTRYGTFE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: YGO9_YEAST
Sequence: MSINALLYVLSLALLIWTGSVVTLLLLLFFCLFLLFFSLHFFCFTREHVHYTLPPKCHSLKFQFDSIPSSSLSLSPFPFLFFPRLRAVAFASPTLSFFFPI
What are the official names of this protein?
Uncharacterized protein YGL149W.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RNPH_BRASB
Sequence: MRPSRRAPDELRPVSLERGVVKYAEGSCLVKFGDTHVLVTATLEDRLPPWLKGQGRGWITAEYGMLPRATLERTRREASAGKQTGRTVEIQRLIGRSLRTAIDLEALGERQITVDCDVLQADGGTRTASITGAWVALADCIKWMKTRNMLKTEVLRANVAAISCGIYNGTPVLDLDYAEDSEAETDANFVMTGDGRIIEVQGTAEKTPFTEAEFLALMALARKGVARLVDLQKMAVA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RL18_CHLAD
Sequence: MGKRTPRELRLRRHNRIRKRVSGTPERPRLNVFRSHAHIYAQVIDDTVGHTLVAASTIEKGWSGSPELTKTQEAALVGKLIAERALQAGITKVVFDRGGYKYHGRVKALAEAAREAGLNF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: 4EBP_DROME
Sequence: MSASPTARQAITQALPMITRKVVISDPIQMPEVYSSTPGGTLYSTTPGGTKLIYERAFMKNLRGSPLSQTPPSNVPSCLLRGTPRTPFRKCVPVPTELIKQTKSLKIEDQEQFQLDL
What is the function of this protein?
Repressor of translation initiation that regulates eIF4E1 activity by preventing its assembly into the eIF4F complex (PubMed:11389445, PubMed:19804760, PubMed:25702871).  Hypophosphorylated form competes with eIF4G1 and strongly binds to eIF4E1, leading to repress translation (PubMed:25702871).  In contrast, hyperphosphorylated form dissociates from eIF4E1, allowing interaction between eIF4G1 and eIF4E1, leading to initiation of translation (PubMed:25702871).  Acts as a regulator of various biological processes, such as innate immunity, cell growth or synaptic transmission (PubMed:10811906, PubMed:11389445, PubMed:27525480).  Acts downstream of phosphoinositide-3-kinase (PI3K) to regulate cell growth (PubMed:11389445).  Extends lifespan upon dietary restriction by regulating the mitochondrial translation (PubMed:19804760).  Acts as a regulator of lifespan in response to cold by regulating the mitochondrial translation (PubMed:28827349).  Acts as a negative regulator of presynaptic release of neurotransmitter in motor neurons: Thor expression is induced in response to insulin signaling, leading to prevent of translation of complexin (cpx), a protein known to regulate the exocytosis of synaptic vesicles (PubMed:27525480).  Acts as a negative regulator of synaptic strength at the neuromuscular junction: Thor expression in response to acute fasting prevents translation, thereby suppressing retrograde synaptic enhancement (PubMed:27916456).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-binding protein, 4E-BP, d4E-BP, eIF4E-binding protein, 4E-binding protein Thor, dThor.
What is the protein family that this protein belongs to?
Belongs to the eIF4E-binding protein family.
Protein: MUTS2_STRU0
Sequence: MNQKILEQLEFQKVKEQFQPYLQTAQGIQELRLLEPSNHYDKISDYFKEIAEMATIFVENHHFSIGNLRDVSESMRRLELEADLNIQELLDIKKLLLVSGEISRFYQDLENVDLQVLKRIFEKIEVFPQLQGSLQAVNDAAFIENFASPELDRLRRQIAENERYSRQLLQDILKKNADYLSESLIASRNGKSVLPVKNTFRHRVSGVVHDISASGNTVYIEPRALVQVNEEMTQLLADERHEIARILKELSQLLRPHSRALANNAWLLGHLDFVRAKYHYLVNNKATIPKISKDKNIQLLNVRHPLLKNPVANDLHFADDLAVIVITGPNTGGKTIMLKTLGLAQLMGQSGLPILADEGSKIAVFDAIYADIGDEQSIEQSLSTFSSHMTHIVDILEESNSNSLVLFDELGAGTDPQEGASLAMAILEQLRLTNIKTMATTHYPELKAYGIESDYVENASMEFDSQSLKPTYRFMQGVPGRSNAFEIARRLGLAETIVKEAEQMTDTDSDVNRIIEELERQTLSSRRRLDHIREVEQENIKFNRAVKKLYNEFSLAKDKEIEKASQEAQAIVELALTESEEILSKLHEKAELKPHEIIEAKSKLKSLVPQRDLSKNKVLKKAKKLREPRIGDDIIVSAYGQRGTLIGQVKGNKWEAQVGLIKMTLKEDEFQLVKVEAEAQKPKKQSINMVKKANQNGPRARLDLRGKRYEEAMQELDAFIDQALVNNMSQVDIIHGIGTGVIREAVTKYLRRHKHVKSFAYAPQNAGGSGCTIATLG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: NINH_LAMBD
Sequence: MTFSVKTIPDMLVEAYGNQTEVARRLKCSRGTVRKYVDDKDGKMHAIVNDVLMVHRGWSERDALLRKN
What are the official names of this protein?
Protein ninH.
What is the protein family that this protein belongs to?
Belongs to the ninH family.
Protein: FPG_SHEWM
Sequence: MPELPEVEVTRQGVSPYLIDQEVTGLTVRNASLRWPVPDLAQQIVGQTIRSVHRRAKYLLIDTDAGTTIVHLGMSGSLRVVTELTPVEKHDHIDLSLASGKILRFNDPRRFGAWLWYELPIDAHPLLSKLGPEPLTDAFNPSYLFESLKGKKKAIKLCLMDNHIVVGVGNIYANEALFAAGIHPQMEAGKVDQERLIILVSEVKQILANAIKQGGTTLKDFTNAEGKPGYFAQKLHVYGRGGESCTQCGNLLSEIKLGQRATVFCGLCQTR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: SCP37_ARATH
Sequence: MVKQQDWSVTTCVLLFLFLASQIHCRSGIHVSKRLEGSKQGDGKSGDTSFNVLRRVLSPKEKDLIKKLPGQPSGVSFRQYGGYVPVNEPSSRFLYYYFVEAIKPNTSTPLVIWFNGGPACSSLGGAFLELGPFRVHSGGRKLFRNPYSWNNEANVLFLESPVTTGFSYSSNPIDLEELGEKGDKATAEDNYIFLMNWLERFPEYKGRDIYIAGQSYAGHYVPQLAQIIIHRNKKTLVNLRGILIGNPSLLTSIQDPYGYEFMLSHGLMSQQQMDNYNQFCLRDDLYDNDKCALSVKTIDDAKKHLDTYNIYAPVCLNSTLSRISKKCTTVLEVDPCSKDYLKAYLNRKKVQKAIHANTTKLPYEWTSCNNELTENWSENDRDTPMIPILHELMGEGVRVMIYNGDVDLEIPFASTLAVVKEMNLTVVKEFRPWFTGGQLGGFTEDYKGNLTFVTVKGAGHSVPTDQPIHALNIFTSFIRNTPLPHTA
What is the function of this protein?
Probable carboxypeptidase.
What are the official names of this protein?
Serine carboxypeptidase-like 37.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBIE_BRUMB
Sequence: MSQQNGNVNRVGAQDRVGASGGMEHSFGFKAVDENEKQGLVNDVFHKVAKRYDIMNDLMSAGMHRVWKDAMVAWLAPSKRPGWTSLDVAGGTGDIAFRIVEASGRQAHVTILDINGSMLGVGRERAIKKGLIDNLEFVEANAEELPFEDNSFDAYTIAFGIRNVPHIDKALSEAYRVLKPGGRFLCLEFSEVELPVLDKVYDEWSFRAIPRIGKMITGDADSYSYLVESIRKFPKQQDFAAMIEKAGFERVSYRNFTGGIAALHSGWKL
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: SIR5_PHYPA
Sequence: MPRAGVAASAFKLRNIWHIHNLHRVRSQQTRLMSDSVEEFSSVFQHAKKVVVLTGAGISAESGIPTFRGEGGLWRDFDATELATPGAFAANPSLVWEFYHYRRTIVAGASPNAGHYAVAALQRRCRRLGKDFILLTQNIDGLHAKAGSTDVVELHGSLWETRCCHCKAVEANRNMPICPALDGKGAPDTVHEANIPSMQLPRCNKCNGLLRPRVIWFGECLERDVLRRTDDALQGCDLLLVVGTSAVVYLFWRNMMEVELHTDFVESLLQDDRLRSRIGLALREKSQYLLVAFRRFKFQGPSSVKLPTALGIGEDELAEMKET
What is the function of this protein?
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins.  Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog 5.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL27_YERE8
Sequence: MAHKKAGGSTRNGRDSESKRLGVKRFGGEAVLAGSIIVRQRGTKFHAGIDVGCGKDHTLFALKDGKVKFEVKGPKNRKFISIEAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: URAA_ECOLI
Sequence: MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVLFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTIIISITTLAVTVLGSVLFRGFLAIIPILIGVLVGYALSFAMGIVDTTPIINAHWFALPTLYTPRFEWFAILTILPAALVVIAEHVGHLVVTANIVKKDLLRDPGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFAILLSCVGKLAAAIQMIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGAAELKGMALATIVGIGLSLIFKLISVLRPEEVVLDAEDADITDK
What is the function of this protein?
Transport of uracil in the cell.
What are the official names of this protein?
Uracil permease, Uracil transporter, Uracil/H(+) symporter UraA.
What is the protein family that this protein belongs to?
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AVT6_YEAST
Sequence: MVASIRSGVLTLLHTACGAGILAMPYAFKPFGLIPGVIMIVLCGACAMQSLFIQARVAKYVPQGRASFSALTRLINPNLGIVFDLAIAIKCFGVGVSYMIVVGDLMPQIMSVWTRNAWLLNRNVQISLIMLFFVAPLSFLKKLNSLRYASMVAISSVAYLCVLVLLHYVAPSDEILRLKGRISYLLPPQSHDLNVLNTLPIFVFAYTCHHNMFSIINEQRSSRFEHVMKIPLIAISLALILYIAIGCAGYLTFGDNIIGNIIMLYPQAVSSTIGRIAIVLLVMLAFPLQCHPARASIHQILQHFAEENVSISATSADEPTVATESSPLIRDSSLDLNEVIEEESIYQPKETPLRGKSFIVITCSILVASYLVAISVSSLARVLAIVGATGSTSISFILPGLFGYKLIGTEHKTAVPLTTKIFKYTGLLLFIWGLIIMITCLTAALKLN
What is the function of this protein?
Involved in amino acid efflux from the vacuole to the cytoplasm.  Capable of transporting aspartate and glutamate.  Requires ATP for function.
What are the official names of this protein?
Vacuolar amino acid transporter 6.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: RL5_SACS2
Sequence: MIKMAESTLPLSQNPMRKVKLSKVTVNIGLGESGDRLQKAYQLLQELTGAKPVYTISKKTIREFGIRKGQEIGVKVTLRGAQAEEFLRKVLEAIGYRLKKSSFDDYGNVSFGIAEHVILPGARYDPEIGIFGMDIAITLERAGYRISRRRRKKAKIPKRHRVTKEEAMEFLRNNFNVQLVEG
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: GCNT3_SHEEP
Sequence: MKMTGWKKKLCRGHHLWALGCYMLLAVVALRLSLRLKCDVDSLDLESRDFQSQRCRDVLYKNLKLPAKRSINCSGITRGDQEAVVQALLDNLEVKKKRLPFTDTYYLNITRDCEQFKAQRKFIQFPLSKEELDFPIAYSMVVHEKIENFERLLRAVYAPQNIYCVHVDVKSPETFKEAVKAIISCFPNVFMASKLVPVVYASWSRVQADLNCMEDLLQSSVPWKYLLNTCGTDFPIKTNAEMVLALKMLNGKNSMESEIPSEYKKTRWKYRYEVTDRLSLTSKMKDPPPDNLPVFTGNAYFVASRAFVQHVLENPKSQRLIEWVKDTYSPDEHLWATLQRAPWMPGSVPYHPKYHISDMTAIARLVKWQGHEGDVSMGAPYAPCSGIHQRAICIYGVGDLHWILQNHHLLANKFDPRVDDNVLQCLEEYLRHKAIYGTEL
What is the function of this protein?
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides.  Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis.  Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.
What are the official names of this protein?
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, C2GnT-mucin type, C2GnT-M.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 14 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: PSBL_NEPOL
Sequence: MTKPNPNKQTVELNRTSLYWGLLLIFVLAILFSSYIFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ICAA_STAAR
Sequence: MQFFNFLLFYPVFMSIYWIVGSIYFYFTREIRYSLNKKPDINVDELEGITFLLACYNESETIEDTLSNVLALKYEKKEIIIINDGSSDNTAELIYKIKENNDFIFVDLQENRGKANALNQGIKQASYDYVMCLDADTIVDQDAPYYMIENFKHDPKLGAVTGNPRIRNKSSILGKIQTIEYASLIGCIKRSQTLAGAVNTISGVFTLFKKSAVVDVGYWDTDMITEDIAVSWKLHLRGYRIKYEPLAMCWMLVPETLGGLWKQRVRWAQGGHEVLLRDFFSTMKTKRFPLYILMFEQIISILWVYIVLLYLGYLFITANFLDYTFMTYSFSIFLLSSFTMTFINVIQFTVALFIDSRYEKKNMAGLIFVSWYPTVYWIINAAVVLVAFPKALKRKKGGYATWSSPDRGNTQR
What is the function of this protein?
N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homomer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide.  Requires IcaD for full activity (By similarity).
What are the official names of this protein?
Poly-beta-1,6-N-acetyl-D-glucosamine synthase, PNAG synthase, Poly-beta-1,6-GlcNAc synthase, Biofilm polysaccharide intercellular adhesin synthesis protein IcaA, Biofilm PIA synthesis protein IcaA, Intercellular adhesion protein A, N-acetylglucosaminyltransferase IcaA.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FUND1_RAT
Sequence: MASRNPPPQDYESDDESYEVLDLTEYARRHHWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQVASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNIIEEATDFIKQNIVISSGFVGGFLLGLAS
What is the function of this protein?
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
What are the official names of this protein?
FUN14 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the FUN14 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: NRDR_SHEWM
Sequence: MHCPFCSATDTKVIDSRLVADGHQVRRRRECAECHERFTTFEGAELVMPRVVKQDGSRQPFDEEKLRGGMLRAVEKRPVSMDQIEQALTKIKSTLRGTGEREIKSEMIGNLMMEQLVNLDKVAYIRFASVYRAFEDVSEFGDAIAKLQK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: LSRK_ECODH
Sequence: MARLFTLSESKYYLMALDAGTGSIRAVIFDLEGNQIAVGQAEWRHLAVPDVPGSMEFDLNKNWQLACECMRQALHNAGIAPEYIAAVSACSMREGIVLYNNEGAPIWACANVDARAAREVSELKELHNNTFENEVYRATGQTLALSAIPRLLWLAHHRSDIYRQASTITMISDWLAYMLSGELAVDPSNAGTTGLLDLTTRDWKPALLDMAGLRADILSPVKETGTLLGVVSSQAAELCGLKAGTPVVVGGGDVQLGCLGLGVVRPAQTAVLGGTFWQQVVNLAAPVTDPEMNVRVNPHVIPGMVQAESISFFTGLTMRWFRDAFCAEEKLIAERLGIDTYTLLEEMASRVPPGSWGVMPIFSDRMRFKTWYHAAPSFINLSIDPDKCNKATLFRALEENAAIVSACNLQQIADFSNIHPSSLVFAGGGSKGKLWSQILADVSGLPVNIPVVKEATALGCAIAAGVGAGIFSSMAETGERLVRWERTHTPDPEKHELYQDSRDKWQAVYQDQLGLVDHGLTTSLWKAPGL
What is the function of this protein?
Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon.  Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
What are the official names of this protein?
Autoinducer-2 kinase, AI-2 kinase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIC_HAMD5
Sequence: MSTKKKSIIKCIDWRSIEEPDLPLEVAGWLMEAGSMTERFERHCHKIIIDLKHEGFIEHQALSDEKELLPESPRYWIREVVMCADDEPWLLGRTVIPQDTLSGPEHALLNLGKTPLGRYLFSSKDLKRDYIQTGRQGDLWARRSLLQLSNKPLLLTEVFLPASPLYCHSRNTKLA
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSCO1_ANDAU
Sequence: IWKS
What is the function of this protein?
Specific inhibitor of store-operated non-voltage-gated calcium channels (By similarity).  Decreases store-operated Ca2+ entry and cytosolic calcium concentration in a dose-dependent manner in U87 cells (PubMed:34946686).  Exhibits anti-tumoral activity by inhibiting proliferation of human U87 glioblastoma cells (IC(50)=300 ug/mL) (PubMed:34946686).  Also exhibits anti-tumoral activity towards human glioblastoma U251 cells, but with lower activity (IC(50) estimated to be more than 500 ug/mL) (PubMed:34946686).
What are the official names of this protein?
Tetrascorpin-1, AaTs-1.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMN_THIDA
Sequence: MPQNLLDFDLAGLTAWFGERGEKPFRARQVFHWIHQAGVTDFAQMTDIAKSLREKLQNEAVVQAPAINFAHLSADGTRKWLFDVGVGNGIETVFIPEDDRGTLCVSSQVGCALECTFCSTGRQGFNRNLTVAEIVGQLWVAQHSLKREPNRTASDHGAGEIAERPVTNVVMMGMGEPLANFENVVTALGVMLDDHAYGLSRRRVTVSTSGLVPAMDRLAERCPVALAVSLHAPNDALRDQIVPINRKYPLAELMAACRRYLVHAPRDFITFEYVMLAGVNDQPEHARQLIALTRDVPCKFNLIPFNPFPDSGYEKPRAEAMRVFREILQDAGYVVTTRKTRGDDIDAACGQLAGRVADRSGRVMKRVHREAA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.