PharMolix/UniProtQA huggingface dataset:
Protein: MURG_BRUAB
Sequence: MDNLANQGVIVLAAGGTGGHLFPAEALAHELRARGWDVHLATDARAQRFVGAFAQDHVHVIRSATIAGRNPVALLKTFWSLWQGNLDSRKLFRRLKPKLVVGFGGYPTLPPLYAASNMGIPTLIHEQNAVMGRANKGLAGRVKAIAGGFLPENSGAYAAKTVITGNPVRSPVLVAAATPYTPAGKDDRFRLLVFGGSQGAQFFSQAIPAAVALLPEHERARLLITQQARKEDEASARQAYEKLGVPADVAPFFNDMPARMADAHFVIARSGASTVSEITVIGRPAMLVPFPHALDHDQAANAAALAAAGGAEVVRQADLSPQRLAEMLQSAMNEPERLEQQAKAAKSVGKPDAARLLADLAEAIASGKTVQEFKEGNRP
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: XPO2_MOUSE
Sequence: MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGREVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSNNVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLISHLEAESIVVHTYAAHALERLFTMRGSNNTTLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSSTIATAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDSIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL
What is the function of this protein?
Export receptor for importin-alpha.  Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm.  In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form.  Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.  Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor.  CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport.  The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
What are the official names of this protein?
Exportin-2, Exp2, Chromosome segregation 1-like protein, Importin-alpha re-exporter.
What is the protein family that this protein belongs to?
Belongs to the XPO2/CSE1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: CPXS_SYNPY
Sequence: MTVMDNPPVTMEDFFETSRGLWLIRRVVHHLDSQDDEAADSNLVIEPFNASDEAVEKVCKVFGIEASEANGGARFWWESNLLAEKRNDDYAAIVIDVPKPEHPDQGYLLRDVGYVEKKPALSTYEFTPDGVLTIKTRYDTNFGIERCWFVNDQIRMRVSSVQFLNGAAMTTYCTEFRCPSKADIEQIANQAKTFAQTNPL
What is the function of this protein?
Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.
What are the official names of this protein?
Chromophore lyase CpcS/CpeS, ORF200.
What is the protein family that this protein belongs to?
Belongs to the CpcS/CpeS biliprotein lyase family.
Protein: EIF3B_MAGO7
Sequence: MAPSYEHLREADLDEDEFDEDEVDVSDLREKFEVQLEQGFDTFVVIDGLPEVTEEQKPKLVKFLLKKLTSVGKTKEDMIDMPMGPDGKSLRFAFVEYSSPGEAAAAVRQLDRVPLDKKHTLRVNKLMDVDRFGREGRIDDEYQPPHIDEFHPRDHLRSFMADPSGRGRDQFVMFRGDHVGVFWNNEKDTPENIVDRPNWTESFVQWSPLGTYLLSMHMQGVQLWGGPKWDRLGRFPHPFVNMAAFSPQENYLVTWSNRPISIPDEGHPALSMDDDGKNYVIWDIATGKPLRSFANLDLPPDDPNKPPRKHPWPAFKWSSDDKYVARLTQGQSISVYELPRMNLLDKTTIKVEGVQDFEWAPSRPQRDGVKTYEQMFCYWTPEIGSNPAKVGLMSIPSKEVVRSLNLFSVSDVKLHWQSEGAYLCVKVDRHSKSKKSQATTLEIFRVKEKGVPVEVVDTIKDTVINFAWEPKGDRFLIITTVTPTGEVAVQPKTAISFFCPEKSKGSTVGNFKHLRTLDKRNSNAIYWSPKGRFVVVATVHNQNSSDLDFFDLDFEGEKPEGEKDLTANLQLMNTADHYGITDVEWDPSGRFVATWASAWKHTMENGYHMYDFKGEQLREEAVEKFKQLQWRPRPPTLLAKEEQKQIRKNLREYSRVFEQEDAERIAGADQEVVDNRRRILEDWYEWRESVDVEVDEESAAMGVSSNPAEELLKAKTAEILASGQEEEQVIEEIVEEVLEESEEIVS
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit B, eIF3b, Eukaryotic translation initiation factor 3 90 kDa subunit homolog, eIF3 p90, Translation initiation factor eIF3 p90 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROS_HUMAN
Sequence: MSAALLRRGLELLAASEAPRDPPGQAKPRGAPVKRPRKTKAIQAQKLRNSAKGKVPKSALDEYRKRECRDHLRVNLKFLTRTRSTVAESVSQQILRQNRGRKACDRPVAKTKKKKAEGTVFTEEDFQKFQQEYFGS
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed:34516797).  Direct regulator of SIRT1.  Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed:17964266).
What are the official names of this protein?
Active regulator of SIRT1, 40S ribosomal protein S19-binding protein 1, RPS19-binding protein 1, S19BP.
What is the protein family that this protein belongs to?
Belongs to the AROS family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL3_PERMH
Sequence: MPKGIIGKKIGMTRVFKDGKAIPVTVIQVEPNYVVNIRTEDKDGYSAVVLGTGEKKEKRTPKPMLAIFKKAGLKPLRHLAEFPLKEGEQPEPGQEVKVEDVFEKGDLVDVTGTSKGRGFASAMKRWDFSGFKKSHGSRYHRAVGSIGACSDPGRVWKTKRMAGHYGNETITVQGLEVVDIIPEKNIILVKGSVPGAPKSVVKLKESVIIHRRKGKRKLERAKAVYAS
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RL333_STAES
Sequence: MKKVPLNCENCGNRNYNVPKKEGSATRLTLKKYCPRCNAHTVHKESK
What are the official names of this protein?
50S ribosomal protein L33 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: DEOC_HALLT
Sequence: MDRDEFAASIDHTVLGPETTWGDVETILNEAADHGMNACIPPCYLPEAADYENAPKTIATVVGFPHGQHAPGVKRDEAVTAWDDGADEIDLVINVGRLKAGEDDAVAAEISDVVAAVPVPVKVIIETALLSDDEKRRACEAAVEADADMVKTSTGFADGGATIRDVELMSEYLPVKASGGVGSYEEATAMLDAGAVRIGASSGVAIVEGHPGDGD
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTR2_MOUSE
Sequence: METSSLWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFALGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLISVPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEMERADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFVLPLALTAFLNGITVNHLVALYSQVPSASAQVNSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTDELYDFYHYFYMVTNTLFYVSSAVTPVLYNAVSSSFRKLFLESLSSLCGEQRSVVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
What is the function of this protein?
Receptor for the tridecapeptide neurotensin.  It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Neurotensin receptor type 2, NT-R-2, NTR2, Low-affinity levocabastine-sensitive neurotensin receptor, NTRL.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTNC_GLUDA
Sequence: MTASTDAIDSVLLDIEGTTIPVAFVHQVLFPYARAAMPGLLAQRADDPAVRAAVADIAALAPGVPPLDQLNAWMDRDEKIGPLKALQGLAWEEGYRTGALRATLYPDVVPALRRWRAAGLRLAVYSSGSEAAQRLIYGHTTDGDVAGLFSGFYDLRIGGKRAAGSYRAILAETGWAAGRTLFLSDITAELDAAEEAGLRTCQLVRPEDGTVAGDRHPVATTLDDVARRFALPVAA
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: P2C36_ORYSJ
Sequence: MLGALLRLLSACGGVWPTSPAPPARSSSSSSAAAAADQAAAEGRDGLLWWRDLARCHAGELSVAVVQGNHVLEDQCRVESGPPPLAATCIGVFDGHAGPDAARFACDHLLPNLREAASGPEGVTADAIRDAFLATEEGFLAVVSRMWEAQPDMATVGTCCLVGVVHQRTLFVANLGDSRAVLGKKVGRAGQITAEQLSSEHNANEEDVRQELMAQHPDDPQIVALKHGVWRVKGIIQVSRSLGDAYLKHSQYNTEQIKPKFRLPEPFSRPILSANPSIIARCLQPSDCFIIFASDGLWEHLSNQQAVEIVHNHQRAGSARRLIKAALHEAARKREMRYSDLMKIDKKVRRHFHDDITVIVLFINYDQLAKGHSQGQSLSIRCALDH
What are the official names of this protein?
Probable protein phosphatase 2C 36, OsPP2C36.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: PRIL_THEVO
Sequence: MRFPPLLFFQDSEAVKRIANSVRGTKDDDAEIKDHSMRFIRNAISGDQQKEILNVDMLRYIAWVLVALNENIVTARTVIRERDAVEDALKNQQPEDIENFADDLKINMKYNRDLERFEIGVFDFVKYASRVTGSQYRLSNQSVIKGIVYCQKDVAIKILRESFVSNMFKVIDSIDQTTASPVLSDQTDSINELREFYKKSVYAKLTIGRGNTKAFPPCMKEIIRNLHEGINVPHMGRLAIASFLHKVGYTEDEIVEYFRNAPDFDESITRYQIKHLSGEISGVEYSPPKCETMRSNHLCFMDDDKLCHQDWMKHPLTYYEVKSRRLG
What is the function of this protein?
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase large subunit PriL.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase large subunit family.
Protein: MRAY_CALBD
Sequence: MLDIDTILAIIISFLIVLIVMPIVIPFLKYLKFGQVVRDDGPKTHHKKSGTPTMGGLVIGLAIIVTSLIFYKKYPAIGAPLIATVAFGLIGFIDDFIKVVLKRSLGLRAREKLVLQFLISITFLYVIQKHLGSDVYLPVINRYIDLKWAYVPVMSVLMVFTVNAVNLTDGLDGLASGVTMIVSLFLAIISIFSKNHDMAIFSGAIVGSCMGFLRYNAHPAVVFMGDTGSLMLGGSIFAIAVMLKQPVLVLVIGGLYIIEAVSVMLQVLYFKLTKKRIFRMAPLHHHFELLGWDEAKVVVVFWIFTILFCLLALAMIQLKI
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRP2_SPIOL
Sequence: MATISSILPCHGLLQHCSSSSSSSKPKFSSQNLVQLQSFSNGFGLKLKTRVSTNPPLLKVRAVVTEETSSSSTASSSSDGEGARRLYVGNIPRNLNNDELRTIVEEHGAIEIAEVMYDKYSGRSRRFGFVTMKTVEDANAVIEKLNDTEIGGRKIKVNITEKPLEGMDIATTQAEDSQFVESPYKVYIGNLAKTVTNELLKDFFSEKGKVLGAKVQRTPGTSKSNGFGFVSFSSEEEVEAAIQALNNSVLEGQKIRVNKA
What is the function of this protein?
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus (PubMed:10874039, PubMed:28007896).  cS22 may have a role in the recruitment of stored chloroplast mRNAs for active protein synthesis (PubMed:12605670).
What are the official names of this protein?
30S ribosomal protein 2, chloroplastic, Chloroplastic small ribosomal subunit protein cS22, Plastid-specific 30S ribosomal protein 2, PSRP-2.
What is the protein family that this protein belongs to?
Belongs to the chloroplast-specific ribosomal protein cS22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 3MG2_ECOLI
Sequence: MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTAIPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGAARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFPEYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPGDVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTPAQIRRYAERWKPWRSYALLHIWYTEGWQPDEA
What is the function of this protein?
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions.
What are the official names of this protein?
DNA-3-methyladenine glycosylase 2, 3-methyladenine-DNA glycosylase II, inducible, TAG II, DNA-3-methyladenine glycosidase II, DNA-3-methyladenine glycosylase II.
What is the protein family that this protein belongs to?
Belongs to the alkylbase DNA glycosidase AlkA family.
Protein: ATP23_ARATH
Sequence: MEDAAAPNSGSEFNPGARRGKSIDECQDMIRRSFRNPIVKFLMEQMEKSGCRVGDNFVKAVVCTGPVAGGYTKGRGITVCSNYLTIQDEVNQVVIHELIHAYDECRAKNLDWTNCAHHACSEIRAGHLSGDCHFKRELLRGFIKLRGHEQECIKRRVLKSLRGNPYCSEVAAKDAMEAVWDTCYNDTKPFDRAP
What is the function of this protein?
Has a dual role in the assembly of mitochondrial ATPase (By similarity).  Acts as a protease that removes the N-terminal 10 residues of mitochondrial ATPase CF(0) subunit 6 (ATP6) at the intermembrane space side (By similarity).  Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of ATP6 with the subunit 9 ring (By similarity).
What are the official names of this protein?
Mitochondrial inner membrane protease ATP23.
What is the protein family that this protein belongs to?
Belongs to the peptidase M76 family.
Protein: CT57_CONSP
Sequence: MRCLPVFVILLLLIASAPSVDAQLKTKDDVPLASFHDNAKGTQHKRIINWCCLIFYQCCLRR
What are the official names of this protein?
Conotoxin Sr5.7.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TSC1_MOUSE
Sequence: MAQLANIGELLSMLDSSTLGVRDDVTAIFKESLNSERGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKHLLDKINEYVGKAATRLSILSLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVVVLTTGVLVLITMLPMIPQSGKQHLLDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENVETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKTLETHDVVIECAKISLDPTEASYEDGYSVSHQLSACFPYRSADVTTSPYVDTQNSYGGSTSTPSSSSRLMLFSPPGQLPQSLSSPSTRLLPEPLQASLWSPSAVCGMTTPPTSPGNVPADLSHPYSKAFGTTAGGKGTPSGTPATSPPPAPPCPQDDCVHGSAAQASATAPRKEERADSSRPYLHRQSNDRGLEDPPGSKGSVTLRNLPDFLGDLASEEDSIEKDKEEAAISKELSEITTAEADPVVPRGGFDSPFYRDSLSGSQRKTHSAASGTQGSSVNPEPLHSSLDKHGPDTPKQAFTPIDPPSGSADVSPAGDRDRQTSLETSILTPSPCKIPPQRGVSFGSGQLPPYDHLFEVALPKTACHFVSKKTEELLKKVKGNPEEDCVPSTSPMEVLDRLIEQGAGAHSKELSRLSLPSKSVDWTHFGGSPPSDELRTLRDQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRAAALEEHNAAMKDQLKLQEKDIQMWKVSLQKEQARYSQLQEQRDTMVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRVELKKANNKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQSKHPDTTKEVEMMKTAYRKELEKNRSHLLQQNQRLDASQRRVLELESLLAKKDHLLLEQKKYLEDVKSQASGQLLAAESRYEAQRKITRVLELEILDLYGRLEKDGRLRKLEEDRAEAAEAAEERLDCCSDGCTDSLVGHNEEASGHNGETRTSRPGGTRASCGGRVTGGSSSSSSELSTPEKPPSQRFSSRWEPALGEPSSSIPTTVGSLPSSKSFLGMKARELFRNKSESQCDEDSVTMSSSSLSETLKTELGKDSGTENKTSLSLDAPHPSSPNSDNVGQLHIMDYNETHPEHS
What is the function of this protein?
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity).  Implicated as a tumor suppressor.  Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (PubMed:16707451).  Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155).  Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155).  Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity).  Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity).
What are the official names of this protein?
Hamartin, Tuberous sclerosis 1 protein homolog.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Protein: FOXF_DROME
Sequence: MIKSEEASDRSVMTMDQLGGYYHDPRAHPPFSHPHAHSHPHQHTHTGHPYRAGNLLTGGNYQAMGGGESPTELIDEKPNIGYMELKHYMDATPTATPVSAAQHYSLSALHSMGTPPASSSPIPPYGVLMTAHSAGSASPQSNSKTPTDLPQDLQYASSSTSTAKVQPLQVQLQPLNHQYASTIKYCSNNTILSANDYQLLTSQEQAGQQQPQQLPAQQLQHSPGGGYMSRISTSPSQVISNAHGMPVLNYSSSSSSPAKSLNGSESSPPSQNHLENKVSGSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFRGPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPRGYRSKIKVKPYAGHANGYYASGYGDAGMDNGNYYASPAFASYDYSAAGATGVSPAGGQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGSATTPPLAHSALGMAPSASSSSSPLGAAATLQSDYAPTASLVAAGYSYATSAGSLDNGLRSISLQQLPGLSSIQHAQAQAQAQAHHHHHQHHASHPSHSHQGHGSMHQNHGTSSTTPPPSQSGGSHGIDHSPIDRKPAYLPPISPPPMMVALNGGGGYYEGLKYAN
What is the function of this protein?
Component of a regulatory network controlling visceral mesoderm development and midgut morphogenesis.  Transcriptional regulator involved in the activation of a large number of genes in the visceral mesoderm including betaTub60D, dpp and Hand.  Binds to and regulates a number of enhancers driving expression in the visceral mesoderm in a temporally and spatially restricted manner.  Also to binds to enhancers cooperatively with activators, such as bap or HLH54F, to coregulate expression of shared target genes in the visceral mesoderm.  Binds to the Ndg enhancer and drives expression of Ndg in the late visceral musculature.  May be involved in the transcriptional regulation of wupA in the visceral mesoderm.  Plays an indirect role in the later stages of salivary gland positioning.
What are the official names of this protein?
Forkhead box protein biniou, Forkhead box protein FoxF, DmFoxF.
What are the subcellular locations of this protein?
Nucleus.
Protein: YK106_YEAST
Sequence: MPFPSILHLTIGRYASYDSNNHMRRRAKLMEAIFRIRTI
What are the official names of this protein?
Uncharacterized protein YKL106C-A.
Protein: CCD80_RAT
Sequence: MTWKMGPHFTMLLAMWLVCGSASQSSALDSDGRPGRKVPLASPISSRSARYLRHTGRSGGVEKSTQEEPNPQSFQRRKSVPVLRLAHPTVRPPPSGINGAPVRPELKPIARGSASEMVRDEGSSARTRMLRFPSGSSSPNILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPNLIPKLMSFLKLEKGKFSMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKGFVQKCKASGIEGHVVQEGNNGGGGGGSTGLGSDKRKEDPRRTQIHPTREPPRKQTTTKAATPQPPPTPRATTLPPAPVTTATRATSRVVTVAARPTTTTAYPATQRPWTSRLHPFSVSHRPPATAEMTTVRGPSVSEQLYPLPRKEQQREKPQATRRPNKATNYGSFTATPPTTLWEGSTRAVGTSRFRDNRTDKREHGHQDPNVVPGPHKPIKGKLPKKKEKILSNEYEAKYDLSRPTTSQGEEELQVDNIPSQNAKESKKHEKPEKPEKEKKKKGKSAKPDKLLRSEKQMKKAEKKSKQEKEKTKKKKAGKTEQDDYQKPTAKHLAPSPRKSVADLLGSFEGKRRLLLITTPKAENNMYVQQRDEYLESFCKMATRRISVVTIFGPVNNSSMKIDHFQLDNEKPMRVVDDEDLVDQHLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPIAMKSVFDLIDTFQSRIKDMEKQKKEGITCKEDKRQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQLSALNGQACNFGLRHITILKLLGVGEEVGGILELFPINGSSTVEREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRCPEDEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY
What is the function of this protein?
Promotes cell adhesion and matrix assembly.
What are the official names of this protein?
Coiled-coil domain-containing protein 80, Down-regulated by oncogenes 1 protein, Steroid-sensitive gene 1 protein, SSG-1.
What is the protein family that this protein belongs to?
Belongs to the CCDC80 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Note=Isoform 2: Cytoplasm.
Protein: LEU3_PICST
Sequence: MSTVTKTITVLPGDHVGTEICNEAIKVLEAIEQATPYQKIHFEFKHHLIGGAAIDSTGVPLPDDSLAAAKSSDAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFASDALLELSPLKSEIVKGTNFTVVRELVGGIYFGERQEQEESADGESAWDTEKYSVAEVTRITRMAAFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVMKEEFPQLTIQHQLIDSAAMILVQSPTKLNGIVITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNSAFGLYEPCHGSAPDLPENKVNPIATILSVAMMLRLSLDSLKEAEALEEAVRQVLDSGVRTADLRGTNSTKEVGEAVVAAVTKILKDAA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, IMDH, Beta-IPM dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLK_SHISS
Sequence: MTKYALVGDVGGTNARLALCDIASGEISQAKTYSGLDYPSLEAVIRVYLEEHKVEVKDGCIAIACPITGDWVAMTNHTWAFSIAEMKKNLGFSHLEIINDFTAVSMAIPMLKKEHLIQFGGAEPVEGKPIAVYGAGTGLGVAHLVHVDKRWVSLPGEGGHVDFAPNSEEEAIILEILRAEIGHVSAERVLSGPGLVNLYRAIVKADNRLPENLKPKDITERALADSCTDCRRALSLFCVIMGRFGGNLALTLGTFGGVYIAGGIVPRFLEFFKASGFRAAFEDKGRFKEYVHDIPVYLIVHDNPGLLGSGAHLRQTLGHIL
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_NITSB
Sequence: MAKRVLIKFSGEALANEDGHGINSKTLKYIASEIKPLVDSGVEVGLVVGGGNIIRGVNASKEGIIRRSSGDYMGMLATVINAVALQEALEYFGLTARVQSAIEMNEICEPFIVRRAMRHLEKGRIVIFAAGTGNPFFTTDTAATLRAVEIGANMIIKATKVDGVYDKDPHKYPDAKKLDRLTYDEALQDNIKVMDDTAIALAKDNALPIIVCNMFEEGNLYDIIVNNNLEKCSIVTDKKENE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.