PharMolix/UniProtQA huggingface dataset:
Protein: HISZ_STAAT
Sequence: MNNSEQLIALKESETAFLKYFNKADYELVDFSVVEKLDWKQLNHEDLQQMGERNFWQHEHQIYALRNDFTDQLLRYYSMYPTAATKVAYTGLIIRNNEAAVQVGLENYAPSLANVQQSLKLFIQFIQQQLRDNVHFVVLGHYQLLDALLDKSLQTPDILSMIEERNLSGLVTYLSTEHPIVQILKENTQQQLNVLEHYIPNDHPALVELKIWERWLHKQGYKDIHLDITAQPPRSYYTGLFIQCHFAENESRVLTGGYYKGSIEGFGLGLTL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_STUS1
Sequence: MTEQALLLVNLGSPASTEVADVRRYLNQFLMDPYVVDLPWPLRRLLVSMILIKRPEQSAHAYASIWWPEGSPLVVLSRRLQEAVKPHWTKGPVELAMRYGEPSIEGALKRLAGQGITQVALAPLYPQFADSTTTTVIQEARRVIREHGLDLKLSILQPFYDQPEYLDALVASAMPHLQQGFDHLLLSFHGLPERHLHKSDPTGAHCLKGDDCCQRAEGAVLATCYRAQCIRTAEGFATRAGLRRDQWSVSFQSRLGRAKWIEPYTETRLDELAEQGVKKLLVMCPAFVSDCIETLEEIGDRGREQFIEAGGQELVLVPCLNTHEDWVQALVQLCSRAPQAL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
Protein: AURA_CHLAA
Sequence: MKITLRMMVLAVLTAMAMVLAACGGGGSSGGSTGGGSGSGPVTIEIGSKGEELAFDKTELTVSAGQTVTIRFKNNSAVQQHNWILVKGGEAEAANIANAGLSAGPAANYLPADKSNIIAESPLANGNETVEVTFTAPAAGTYLYICTVPGHYPLMQGKLVVN
What is the function of this protein?
Probably a soluble electron acceptor for the integral membrane protein electron transfer alternative complex III (ACIII).
What are the official names of this protein?
Auracyanin-A.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Possibly located on the extracellular face of the cell membrane.
Protein: RLMN_MALP2
Sequence: MLMNSIYSFTLQELKKELTKNNIKAFVAEQIFDWIYSKHVDSFDEMKNISKENIEKLKQLFSFENMVVDKLQVDKHDGTVKFLLKLEDGNFIETVIMKFNYGYSVCVTSQIGCNMACKFCASGLIRKKRNITVGEFIKQFIIAKEYVEKNFNDKLTHMVVMGIGEPFDNFENLIQFFEVIKQQKGLCISPRKITVSTCGLVEKIKEFADLKNQVNLAILLHAPNNEIRNKIMPINKVYSLDKVIEAMDYYIKVTKRRVTIEYILIKDVNDSDENAVELAKLLKGKLCYVNLIPYNKVVENNYFRSVRGKQFFDVLKKNNIQATIRLERGSSIDAACGQLRIKKILELRNAKV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_CAMLR
Sequence: MVTLEEALKFSKEEIINLKKELNQKAKEQKHLGAYVEQFLDKDLSESGDGVPVAIKDNISVKDWELTCASKILQGYVAPYDASVITNLRKNNLSPFGRCNMDEFAMGSTSATSFYGKTLNPHDNTKVPGGSSGGSAAAVASGLAIASLGSDTGGSVRQPAAFCGCVGFKPSYGRVSRYGLAAYSSSLDQIGVLTQNVKDAAILYDVIAGYDEKDSTSANIAFEPTAPKLNANKKLKIAVIKNYIDQTNDDVKQALLKTIDMLKANGYEIVYKDLMDSTFDVAAYYIIAAAEASANLSRYDGVRYGRRSEKCDNLSQMYINSRSEGFGEEVKRRILLGTFVLSSGYYDAYYIKAQKARRFIKQKYEEILNDCDLIFMPVAPSVAFGFNDVKTPIQMYLEDVFTISVNLAGLGGISVPVGKNENGLNISAQLICKAYDEQTLLDGALSLEEIIKNK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: MT2B_PIG
Sequence: MDPNCSCAAGGSCTCAGSCKCKDCRCTSCKKSCCSCCPAGCARCAQGCICKGASDKCSCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
What are the official names of this protein?
Metallothionein-2B, MT-2B, Metallothionein-IIB, MT-IIB.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: KATG_BURTA
Sequence: MSNEAKCPFHHAAGNGTSNRDWWPDQLDLSALHRHSSLSDPMDRDFNYAQAFEKLDLAAVKRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGRSISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGPASNVGPEPEAAGLEEQGLGWKSAYGTGKGADAITSGLEVTWTKTPTQWSNNFFENLFGYEWELTKSPAGAHQWVAKDADAVIPDAFDPSKKHRPTMLTTDLSLRFDPAYEKISRRFHEHPDEFADAFARAWFKLTHRDMGPRARYLGPEVPAEELLWQDPIPAVDHPLIDAADVAALKAQVLASGLSVSQLVSTAWAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLATVLATLEAIRRTFNGAQSGGKRVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRMDASQEQTDVESMAVLEPLADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVLLGGLRVLGANAGQSRHGVFTARAQALTNDFFVNLLDMSTEWKPASADADVFEGRDRATGALKWTGTRVDLVFGSHSQLRALAEVYASADAQEKFVRDFVAVWNKVMNLDRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: EUTN_SALTY
Sequence: MEADMKLAVVTGQIVCTVRHQGLAHDKLLMVEMIDAQGNPDGQCAVAIDSIGAGTGEWVLLVSGSSARQAHRSELSPVDLCVIGIVDEVVAGGKVVFHK
What is the function of this protein?
Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source.  It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078).  EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
What are the official names of this protein?
Bacterial microcompartment shell vertex protein EutN, Ethanolamine catabolic microcompartment shell protein EutN, Ethanolamine utilization protein EutN.
What is the protein family that this protein belongs to?
Belongs to the CcmL/EutN family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: MINC_BEII9
Sequence: MTAAVRSRPSLRFRGRSFHAMVLAPEVPVAAWFTDLDEWIQRSPGFFQGRPVVLDVSNLSLSRSALADLLQEFSARGIRIMGLEGADLSGHDLQMPPVLRGGRRENVIDLFAGEEAQASGKINSQIQEGDAHDVESAGALLIETPVRSGQSIMHLEGDVIVVGSVASGAEIIAGGSIHIYGALRGRAIAGAQGRKARIFCRKFEAELLSIDGYYMTADTVEPHLLGRPVQVWLEGDRLMVSIQD
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: PUR4_PSEPK
Sequence: MLILRGAPALSAFRHGKLLEQLSQKVPAVTGLYAEFAHFADVDGELTADQQQVLGRLLKYGPSVPVQEPTGRLFLVVPRLGTISPWASKASDIAHNCGLQSIQRLERGIAYYVAGTLSDADAELIAAELHDRMTQRVLGQLEQAADLFSHAQPKPMTSVDILAGGRDALAKANIDLGLALAEDEIDYLVNAFQGLKRNPNDIELMMFAQANSEHCRHKIFNASWDIDGQAQEKSLFGMIKNTYQMHNEGVLSAYKDNASVIVGNVAGRFFPNPETRQYGAVQEPVHILMKVETHNHPTAIAPFSGASTGSGGEIRDEGATGRGAKPKAGLTGFTVSNLRIPGFEQPWEQAYGKPERIVDALDIMIEGPLGGAAFNNEFGRPALTGYFRTFEQAINTPHGEEVRGYHKPIMLAGGMGNIREDHVQKGEITVGAKLIVLGGPAMLIGLGGGAASSVATGASSADLDFASVQRENPEMERRCQEVIDRCWQLGDENPIAFIHDVGAGGISNAFPELVNDGGRGGRFELRNVPNDEPGMAPHEIWSNESQERYVLAVSAVDFERFKAICERERCPFAVVGEATEEQHLTVSDSHFGNTPVDMPLDVLLGKPPRMHRSVTREAELGDDFDPSELDLDSAVQRVLNHPAVASKSFLITIGDRTITGLVARDQMVGPWQVPVADCAVTATSFDVYTGEAMAMGERTPLALLDAPASGRMAIGETLTNLAASRIEKLSDIKLSANWMSAAGHPGEDARLYDTVKAVGMELCPELGITIPVGKDSMSMKTKWSDEGVEKSVTSPMSLIITGFAPVTDIRKTLTPQLRMDKGETDLILIDLGRGKNRMGASILAQTYGKIAAQAPDVDDAEDLKAFFAVIQGLNADGHLLAYHDRSDGGLVTTVLEMAFAGHCGLDLQLDPLTDSKGEVPAILFNEELGAVIQVRQDATPDVLAQFSAAGLGEECVAVIGKPVNNAEVTISLNGEVLFDDDRRMLQRQWAETSYQIQRLRDNADCADQEFDLLLEEDNPGLSVKLGFDVNDDIAAPYIKKGVRPQVAILREQGVNGQVEMAAAFDRAGFAAIDVHMSDILAGRVDFEAFKGLVACGGFSYGDVLGAGEGWAKSALFNARARDAFQAFFERTDSFALGVCNGCQMMSNLHELIPGTEYWPHFVRNRSEQFEARVAMVEVQKSNSIFLQGMAGSRMPIAIAHGEGHAEFASEEALLEADVSGCVALRYVDNHGKVTEAYPANPNGSPRGITGLTSRDGRVTIMMPHPERVFRAVQNSWRPDEWQEDAALMRMFRNARVWVN
What is the function of this protein?
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_MYCBP
Sequence: MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEGAYDEQDYAETEQL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MP2K1_MOUSE
Sequence: MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
What is the function of this protein?
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation.  RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2.  Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade.  Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).  Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements.  One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis.  MAP2K1/MEK1 has been shown to export PPARG from the nucleus.  The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Membrane; Peripheral membrane protein. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (By similarity). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742).
Protein: SYA_MYCAP
Sequence: MKKLTSTEIRQKWLDFFESKNHLVIESKSLIPVNDSSLLWINSGVATLKNYFSGKKVPPAFRLTNSQKAIRTNDIENVGVTSRHHTFFEMLGNFSIGNYFKKEAIAYAKEFLVNVLEMDFEKLYFTYYEEDLEAKNYWLENGVDESHLISGTRDTNFWDLGSGPCGPCTEIFYDRGEKYDRRGLDLLKNDIENDRYIEIWNIVFSQFNNDGEGNYTELKQKNIDTGAGLERLASIMQDVPTNYDSDLFINIIREIEKYSPYKYVIENYFAKDEHQGEINTNFKIIADHIRTVVNAIADGAKVSNVGRGYIIRRLLRRSYYKGMQLGIKDLFLHKLVKVVKDSLPYEYNEKDVIDAIKEEELLFSKTIEKGKILLESFLDNENKVFDGAVAFNLLETYGFPIELTAEILHQKGISVDMDAFELAKEKHALASKGGKATGMDKVINSLALIDKKMDNFVGYSELSANSKVLKLFDEENEVEGFETGGYVLLETTPFYATSGGQRHDKGFIIQGENKIKIIDVFKDKFGNHIHFVEGKMNNHEPVSSFVDPNIRIGLERNHSGTHLLFCALRNVLGSHIEQLGSDNNEERLTFDFPADEKPSDEQIKAVEDLVRSYITKSIDREYITTTVDKAREMGAIMTLEEGEYMDPRAIRVVRFGDITSDLCGGTHLSNTSKLESFKITNVEKKQAGVFRIRAISSSKLVNEYLSKVNKKLNEELATIIKKIKELKSDYVAPAINENEPDIETLNASINKRIDELREVYKQLLKESSNLEFDYETVKFDKIKDYDVYINLDVDASAVKLIAASIRDKFQLGKTVAIIGSKNENELLLAIATRAIDANKMFKKLASELNGRGGGAPILAMGKMNYSEDIESLIKDYLPDA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_PROM2
Sequence: MSPLALVSVSDKKNIIQFCKELIENFNYKILSSGGTAKHLIEAKIPVIKVADFTNSQEILGGRVKTLHPKIHGGILAKRTDEEHQIDIKANDLELIDLVVVNLYPFKKTIDQGAKWEDAIENIDIGGPSMIRSAAKNHKYVSVLVDPSQYQNFLEESKKGELKESYKAKLALEAFQHTADYDTAISNWISKERGFQSSKHIKSYPLIKSLRYGENPHQKAFWYGLSNIGWNSAKQLQGKDLSYNNLLDLESALTTVLEFGYAEKDELTTDTFASIILKHNNPCGASVSNSASQAFLNALECDSVSAFGGIVAFNSNVDSETAIQLKDIFLECVVAPSFDEKALEILKVKKNLRILKLSKDQLPKNNQTSTKSIMGGLLVQDTDDNKEKSEGWISVTNKNPSNQMNLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALKAAGKLCSGAVLASDGFFPFADTVELANEYGIKAIIQPGGSLRDQESIDMCNAKGIAMIFTQKRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: YHCA_ECOLI
Sequence: MLRHITFTVFITTSMNTLATGMVPETSVLLVDEKRGEASINIKNTDDHPSLLYTTIVDLPESNKSIRLIPTQPVIRVEAGQVQQVRFLLQATVPLQSEELKRVTFEGIPPKDDKSSRVTVSIRQDLPVLIHPASLPEERETWKFLEWRKNGDQIEISNPSNYVVRMTLQFKTLPSGKTGAINKTYFLPHTSTTTALTNATDTKVEFYPASRYGYRGNKYVTDLK
What is the function of this protein?
Could be required for the biogenesis of a putative fimbria.
What are the official names of this protein?
Uncharacterized fimbrial chaperone YhcA.
What is the protein family that this protein belongs to?
Belongs to the periplasmic pilus chaperone family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CPI1_PIG
Sequence: MESEEMLAGGLTEPRPATPEIQEIANKVKPQLEEKTNKTYEKFEAIIYRSQVVAGTNYYIKVHVGGNNYVHIRVFQSLPHQEDPLKLIGYQVDKTKDDELTGF
What is the function of this protein?
Potent inhibitor of cathepsins L and S, and papain.
What are the official names of this protein?
Leukocyte cysteine proteinase inhibitor 1, PLCPI, Stefin-D1.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRS4_DICDI
Sequence: MGNNQSQGQGDKGEKKDQPKYQPPPPPTQFGKKKKRRGAETSTKLPVITPHSKCKLKQLKLERIKDYLLMEQEFLQNYDLNQPKVDENSKEQADEKIIEELRGDPLTVGNLEEIIDDNHAIVSSTVGPEHYVRIMSFVDKSKLYLGATVLLNNKTLSVVGVIDGEVDPMVNVMKVEKAPTESYSDIGGLEAQVQEMKEAIELPLTHPELYEEIGIKPPKGVILYGEPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVADECAPSIVFIDEIDAVGTKRYDSQSGGEREIQRTMLELLNQLDGFDARTDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDIKTKRKIFEIHTAKMNLSEDVNLEEFVMSKDDLSGADIKAICTESGLLALRERRMRVTHTDFKKAKEKVLYRKTAGAPEGLYM
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).  Plays an important role in regulating both growth and multicellular development.
What are the official names of this protein?
26S proteasome regulatory subunit 4 homolog, Tat-binding protein alpha, DdTBPalpha.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RNPA_SHIB3
Sequence: MVKLAFPRELRLLTPSQFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALSEALEKLWRRHCRLARGS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL21_ANASK
Sequence: MYAVIRTGGKQYRVAQGDRVKIEKLAGDVGGKVNFDVLLVGGEGEAKVGTPTLAGVTVEGEIVAQDKHKKVIHFRKKKEGWTKKRGHRQPYTEVLITTVRA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: DUSB_VIBVU
Sequence: MKIGNYQLKNKLIVAPMAGVTDRPFRELCLRYGAGMAVSEMMSSNPQLWKTSKSKQRMVHEGESGIRSVQIAGSDPQLMADAAQFSVENGAQIIDINMGCPAKKVNKKLAGSALLKYPDIIEQILKAVVDAVDVPVTLKTRTGWDTENKNCIHIAKLAEDCGIQALALHGRTKACMYKGEAEYDSIKAVKQAVSIPVIANGDIDSPEKAKYVLEYTGADALMIGRPAQGRPWIFQEIHHYLENGTTMPELPIEEVKSIMLGHVQALHEFYGEYLGPRIARKHVGWYLKEHEQASEFRRTFNAIDAAMLQLEALEGYFDNVAS
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
What are the official names of this protein?
tRNA-dihydrouridine synthase B.
What is the protein family that this protein belongs to?
Belongs to the Dus family. DusB subfamily.
Protein: PXPA_ALKMQ
Sequence: MYQVDLNSDIGESFGAYELGMDGEVVKYITSANIACGWHAGDPMVMEKTVQAAIRNKVAIGAHPGFPDLMGFGRRNMVVTQEEAKAYVKYQIGALWAFTKAAGVAIQHVKPHGALYNMAAKDEGLAKAIAEAVYEIDPNIILVGLANSKMTEVGEKLGLKVAHEVFADRAYNSDGTLVSRNTKGAVIHDSDLAVARVVRMIKKGKVEAINGEDVSIKAHSICVHGDNEHALEFVNKIRETLGKEEIQVISMDALLK
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: PA2B1_CRODM
Sequence: HLLQFNKMIKFETRKNAIPFYAF
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 CB1, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NRDR_MYCBT
Sequence: MHCPFCRHPDSRVIDSRETDEGQAIRRRRSCPECGRRFTTVETAVLAVVKRSGVTEPFSREKVISGVRRACQGRQVDDDALNLLAQQVEDSVRAAGSPEIPSHDVGLAILGPLRELDEVAYLRFASVYRSFSSADDFAREIEALRAHRNLSAHS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: UVRC_SHEPA
Sequence: MSDEFNANQFLKTVTSSPGVYRMYDAKDAVIYVGKAKDLKKRLSSYFRKNLANVKTQALVSHIANIDVTVTHSETDALILENDYIKQYMPKYNVLLRDDKSYPYILLSNHQHPRLAYHRGPKRDKGQYFGPYPNGGAVRESLHLMQKIFPIRQCDDLYYKSRSRPCLQYQIGRCSAPCVDLVSEEDYQEQVRLATLFLKGKNQQVMSVLVQKMEQASSDMRYEQAALYRDQITALRRVSEQQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFMLQFYLNSDSQRLTPKEILISDAFEEQAELADAIQSAQNKKVEIKTQVRGERASFLRLALTNATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDISHTMGESTVASCVVFNREGPSKADYRRYNITGITPGDDYAAMKQAITRRFDKITEKGKIPDILFIDGGIGQLRIAQKVVDEQFVALDNAPTLIGVAKGEGRKPGLETLIYGESEESFSLPADSGALHLIQHIRDESHRFAITGHRNKRQKTRNTSTLETIAGVGPKRRKALLQYLGGLQEVKGASVSELAKVPGISLEMAQTIHDALRG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAK21_ORYSJ
Sequence: MDPGVEKKKQQMELVDVESGGLPVERQDSLFREAVRAEHAGAAHWDEQDSWGRTMSLAFQCVGILYGDIGTSSLYVYSSTFEHGIGHPDDVVGVLSLIVYSFMLFTVIKIVFVALHANDHGDGGTFALYSLISRHAKVSLIPNHQAEDELISGYSSSGKPSATLRRAHWLKQLLEASKAAKISLFLLTILAIAMVISDAVLTPPISVLSAVGGLREKVPHLTTDQIVWITVAILVVLFAIQRYGTDKVGYSFAPIILLWLLLIGATGLYNLIKHDISVLRAFNPKYIIDYFRRNKKEGWVSLGSILLCFTGSEALFANLGYFSIRSIQLSFSFALLPSVLLTYIGQAAFLSKNPKNVANTFFAATPISLFWPTFIMAIAASIIGSQAMISCAFATVSHLQSLSCFPRVKILHTSKRFPGQLYIPGVNFLLCVAACVVTVSFKTTVIIGKAHEICVILVMIITTLLMTIVMLLVWKINILWVALFFITFTSTEAVYLSSVLYKFTHGPYVPVAMSVVLMVVMIVWHYVHVKRYKYELEHTVSTDKVKEMLESHDLKRVRGVALFYTELVQGIPPIFPHLIEKIPTIHSVLVFISIKHLPVPHVDTSERFLFRQVELKDYKVFRCVARYGYRDSLEEAKDFVVTLLENLQDYIRDVNLYTDEPHTISAHSSCNHSFSREKPSGRYAVHAEDMLTPIESFSEITALSNYGSDRLPHFKASKMNMEELAKIEQEQMFIEKEMEKGVVYILGETEVVVRPHSSLLKKIVVNYVYSFLRKNFVQGQKMLFIPHRQLLKVGISYEI
What is the function of this protein?
High-affinity potassium transporter.
What are the official names of this protein?
Potassium transporter 21, OsHAK21.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RIMP_CALBD
Sequence: MSKITKKVEELVKPILERYGFDLVDIEFKKEGKSHFLRVYIDKPGGITIDDCQLVSEELSEKLDIVDPIPFSYYLEVSSPGVDRPLVTDRDFIRNKGKVVDVFLNQPFLNRTRITGELVEKNEKSLILIVDKEKIVIPIENIKKVKLAIRF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.