PharMolix/UniProtQA huggingface dataset:
Protein: TRMFO_STRU0
Sequence: MSQSYINVIGAGLAGSEAAYQIAKRGIPVKLYEMRGVKATPQHKTSNFAELVCSNSFRGDSLTNAVGLLKEEMRRLDSIIMRAGEAHRVPAGGAMAVDRVGYAEAVTAELENNPLIEVIRGEITEIPNDAITVIATGPLTSDALAEKIHALNGGEGFYFYDAAAPIIDKSTINMDKVYLKSRYDKGEAAYLNCPMTKEEFLAFHEALTTAEEAPLNSFEKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYKGPRDGDYKTPYAVVQLRQDNAAGSLYNMVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLKQTFQSRANENLFFAGQMTGVEGYVESAASGLVAGINAARLFKGEEAIIFPETTAIGSLPHYVTHTDSKHFQPMNVNFGIIKELEGKRIRDKKERYEAIAERSLKDLEAFLNS
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_CITBB
Sequence: MLLVIDVGNSNIVLGIYDEERLVRDWRVSTDKSKTIDEYGILFHDLFRLADIVFTDVKDIIISSVVPTLTGVLEKLSRQYFKISPYVVGPGIKTGMPIHYDNPKEVGADRIVNAIAGFEKYRTALIIVDFGTATTFDYVNKKGEYCGGAIAPGLAISMEALFMKASKLPRVDIARPPSIIAKNTVNSMQAGIFFGYVGLVDGIVQRMKGEGKENPKVIATGGLASLIAPESVTIEEVDEFLTLEGLRIIYQRNK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETS_ORYSJ
Sequence: MTPVVHCSVGNISLFHIGSFRPSHEIQIRRFRSTERYSRVPSRRLLQPQRAFNLISIYKRSSWSSARRPRTLSAATVGTDVTVEDPNPPPSGETSEESSEDTAPDTAEASEQAEASTSSIPKAGRNIRKSEMPPLNDEDLVPGASFTGKVRSIKPFGVFVDIGAFTEGLVHISRVSDGFVKDISSLFTVGQEVSVRLVEANKETGRISLTMRTGGDYVKPKTETPKAASGGRNTTATTSRGSPRQTRERDEAKSMGETNYVQGQFLDGVVKNSTRAGSFVTLPDGSEGFLPREEEAVALFTLIGHSALEVGQQVRVKVLNVVRGQVTLTMKEGEDDEEDLASLNTQLKQGWSRGTNAFELAFRRNKEISAFLDQREKIIVPDVQEAAVASVGTELDAEVGIEQSPGKEPETGNAESVAIDSSITEVKETDSIAAVEKDSEISKTESVETASSVVISEDDSTVDGKLVEPTASVSATETEIKEDSSEGSVTTEPTEAASTEFVTAVVEESAPTASSVETSEDDSTVDDKLVEPTASVSATEAESKEDSSEGSVASTESVTAVVEESAPVSSVAIEVPAPEASEASAQEIIEDSTTVEGAADDQTVESDSPPPEGVELSSNGAPDSSIAEDKPDEPEESLIVEEVPVTASSESEDKEPAAVPEEVAASSEKTADVAVAGAEASTATATISPALVKQLREATGAGMMDCKKALAESGGDIEKAQEFLRKKGLAAADKRAGRATAEGRIGSYIHDSRIGVLIEVNCETDFVSRGDIFKELVDDLAMQVAACPQVQYISLDDVPEEVMKKETELEMQREDLLSKPEQIRSKIVEGRVKKRLGEYALLEQPFIKNDKVTISEWVKQTIATIGENMKVNRFVRYNLGEGLEKRSQDFAAEVAAQTAAKAPPAAPPKDDKPEETAETEEKKPAVAISAALVKQLRDETGAGMMDCKKALAETGGDIQQAQEFLRKKGLSSADKKSSRLTAEGLIGAYIHDNRIGCMIEINSETDFVARNEKFKELVNDLAMQVVACPQVEYVSIEDIPESVVIKEKEIEMQREDLQSKPENIREKIVEGRISKRLGVLALLEQPFIKDDSKTVKDLVKETIATLGENIKVRRFTRYTLGEN
What is the function of this protein?
Binds to psbD and psbA 5'-untranslated regions (UTRs) in vitro.
What are the official names of this protein?
Polyprotein of EF-Ts, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RPOZ_CLOBA
Sequence: MNNSMINPSIVDLLTKVGDRYSLVILTSKRAREIIEGAEPLIKVDSHKPLTIAINEVNEDIVKYEE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RPCH_CARMA
Sequence: MVRRTGVTLLVVALVVVALVSSVSAQLNFSPGWGKRAAAGSGSSGGVGEAVSALHHSVGGAPGGVVPPGSSSSSGDSCGPIPVSAVMHIYRLIRNEAVRLVQCQDEEYLG
What is the function of this protein?
This hormone adapts the animal to light backgrounds by stimulating concentration of the pigment of its red body-chromatophores.
What are the official names of this protein?
Red pigment-concentrating prohormone.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2248_DICDI
Sequence: MKVSLLIFLIILVGVIKSFDINSIDDSHWESDEGFEHHKCWKNLTGYYTEFALSAYNTMFPTPYGVIPVSFYEGGVVTADIKGQQMYVHYGIVAKNFTTWGQYYAYGKNQTQYVVNNSSCVAMKLQFPFPDKLPKFKKVGTTKIGQTDVDVWIVKGKQQCNVTRSCILIQKDTCTLMSANFGNKDKSNLGFSLLNYYRYENKPHYDKFQLPSQCWDVKPKDENENKEEQGLFANEEELENKEYFGDNQQAPSMRITKNNPHLNNNNNNKKYHHREHETPNPDLIKTTTKTSTKTTSFSRATNDSPKSIDFHHLF
What are the official names of this protein?
Uncharacterized protein DDB_G0292248.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRG_CARHZ
Sequence: MTKFIFVTGGVVSSLGKGITAASLGRLLKSRGLKVAIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLTKNSNVTTGKVYWAVISKERRGDYLGGTVQVIPHITNEIKERILRVAKESNPDVVITEIGGTVGDIESLPFLEAIRQLKNDVGKDNVLYIHVTLVPTLRVTGELKTKPTQHSVKELRSIGIQPDIIVARSEQPLSREITEKIALFCDIDKNAVIQAVDASNIYEVPLKLKEEGLDDIVIKKLGLTCGEPDLSEWEQIVERYKNPKFEVTIGIVGKYVSLPDAYLSVAEALRHAGIYHETRVNIRWIDSEMLEKEPVEKYLSNLDGILVPGGFGDRGVEGKIKAIQYARENKVPYLGLCLGMQTAVIEFARNVAGLKDANSSEFKPDGPHSVIDLLPEQKEVEQLGGTMRLGLYPCKLVPGTKAHAAYGEEIIYERHRHRYEFNNEYRELLTGLGLVISGTSPDGRLVEIIELSDHPWFVATQFHPEFKSRPNRPHPLFREFIGASLKTNKLF
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CEFE_AMYLA
Sequence: MTDATVPTFDLAELREGLHQEEFRHCLREKGVFYLKGTGLPAEADHASGREIAVDFFDHGTEAEKKAVMTPIPTIRRGYAGLESESTAQITNTGKYTDYSMSYSMGTADNLFPSAEFEKAWEDYFARMYRASQDVARQVLTSVGAEPEVGMDAFLDCEPLLRLRYFPEVPEDRVAEEQPLRMAPHYDLSIVTLIHQTPCANGFVSLQVEVDGSYVDIPAQPGAVLVFCGAVATLVADGAIKAPKHHVAAPGADKRVGSSRTSSVFFLRPNGDFRFSVPRARECGFDVSIPAETATFDDWIGGNYINIRKTAAAR
What is the function of this protein?
Catalyzes the step from penicillin N to deacetoxy-cephalosporin C.
What are the official names of this protein?
Deacetoxycephalosporin C synthase, DAOCS, Expandase.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: RNH2_ACTSZ
Sequence: MSEFEYPQGYGLIAGVDEVGRGPLVGAVVTAAVILDPNNPISGLADSKKLSEKKRLVLAAEIKEKALAWSLGRAEAEEIDELNILHATMLAMRRAVKSLKILPHLVLVDGNRVPELDMPAQAIIKGDGKVAEISAASILAKVARDQEMETLDKQFPQYEFAKHKGYPTKVHLEKLMRFGALPQHRRSFAPVRKAIEEFNRTQ
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O16A_CONPU
Sequence: MKLTCVMIVAVLFLTAWTFVTADDSKNGLENHFWKARDEMKNREASKLDKKEACYAPGTFCGIKPGLCCSEFCLPGVCFGG
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.  This toxin shows weak effects on rNav1. 2/SCN2A (EC(50)=2. 9 uM), rNav1. 4/SCN4A (EC(50)=5. 2 uM), hNav1. 7/SCN9A (EC(50)=1. 9 uM) and rNav1. 7/SCN9A (EC(50)=6. 4 uM) (PubMed:10627583).  In vivo, this toxin shows different effects.  In mice, injection of this toxin causes hyperactivity, rapid running, limb extension, and death.  In fish, the peptide elicites spurts of rapid swimming, with twisted motions, quivering fins and the lockjaw extended mouth syndrome.  Rigid paralysis and death are observed at higher doses.  In mollusks, this peptide is inactive.  Injection of this peptide together with the kappa-conotoxin PVIIA causes the sudden tetanus of prey (STOP) syndrome, which is a single, lethal 'fin-pop' in envenomed fish.
What are the official names of this protein?
Delta-conotoxin PVIA, Lockjaw peptide.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LIAS_RAT
Sequence: MALRCWDAARSLGSRIFGRYACSVRALSSLPDEKKKFLHNGPDLQDFVSGDLADKSTWDDYKGNLKRQKGERLRLPPWLKTKIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDPSEPDNTARAIAEWGLDYVVLTSVDRDDVVDGGAEHIAKTVSCLKERNPKILVECLTPDFRGDLRAVEKVALSGLDVYAHNVETVPELQRKVRDPRANFDQSLRVLKHAKEVQPDVVSKTSIMLGLGETDEQVYATMKALRAADVDCLTLGQYMQPTKRHLKVEEYVTPEKFKYWEEVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKVSKV
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: THII_NOCFA
Sequence: MSGFCVLAKYGEIAVKGRNQGWFENCLVRNLRHAVGGPVLIRRRGGFLVASAHHRDPAELTRRLQEVMGLNVVQPALSVPPTVEDATAAAVDLLRRRHAERPGAPVPTFAVRARRRWKDFPMSSDAFAAHIGARVCAELGWRVDLAAPEVPVLVEVDRREIFVSVERLPGQGGLPVGCSGRALVLLSGGYDSPVAAYRAMRRGLHCDFVHFTGAPYTDPSSMYKAYALARELGRYQTPARLYVVPVGNAQKTLATAGAEELQIVARRRLYLRIAEELARRRQRDALVTGDSLGQVASQTLSNLVSADQACTLPVLRPLIGWDKQEIITEARRIGTAEISVLRDEDCCSLLAPSEVATRTNPADLRVIEQRADIDTLVEQALEHVTVLTPGRVRGAEPPRAKVARPTVVAG
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTH_SHIBS
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWTPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2722_XANOR
Sequence: MKPLHTPKPAQIWVDADACPAVIRDILFRAAARTGTALTLVANHSLSTPTLPHVRAIQVPGGPDAADDAIAERVAAGDLVVTQDIPLAARVLEAGATAVGPRGEPFTSNTIKERLSVRGFMEELRGAGIATGGPSALHARDRQAFAAQLDRWLAAQPRPPL
What are the official names of this protein?
UPF0178 protein XOO2722.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: FMT_LACAC
Sequence: MTSVIFMGTPEFSVPVLEGLIEAGYEIRAVVTQPDKKVGRKQKIAKTPAKIAAEKHDLPVLQPVKLSGSEEMNQLIDMHADLIVTAAYGQFLPTKFLKSVNIAAVNVHGSLLPKYRGGAPIQYSLINGDKETGITIMEMVKKMDAGDIYAQEAIKIEPEDNAGTLFSKLSILGRDLLLKTLPSIIDGSVKKTPQDPDKVVFSPNITKEQERLSIDMTAEQANNMIRALNPDPGAYLMINGQRFKVWEAEVASDSSSLEAGTVVANKGRFAISFADNTVLNLLEVQPSGKKRMNIKNFLNGQGSKFVTGEEIVDK
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: LSP1N_HUMAN
Sequence: MLDIFILMFFAIIGLVILSYIIYLL
What is the function of this protein?
May play a key role in the skin fibroblasts (FBs)-keratinocyte-like cells (KLCs).
What are the official names of this protein?
LASP1 neighbor protein, Long intergenic non-protein coding RNA 672.
Protein: AIM32_ASHGO
Sequence: MGVAKYTKWGLQLRRAFHGGFKLVDIEAREPVKCACESEVASYNGALPPDCRLDTSIPLPSKPPAYSKHVLLVSPRADAWVADWQSKLELNPHWPYNAVSTFKRALRTAYRGDGILVNAVCFQGSTLLPKLRHGHAQFLVLPEFQVYDVYQDSIEEFAYFIGGGKGKEAPSRLGFLDYAEGSGNQAARREQGPGCAAAGPIFQGQPFNRNLLLVCGHLQRDARCGLIAPELVDALKGEPYLAETEIGIVSHIGGHKLAGNLIYYSRADPSHVDKPLVDALWFGKVLPAMIPTLVDALSQKKIVSANYRGGISF
What are the official names of this protein?
Altered inheritance of mitochondria protein 32.
What is the protein family that this protein belongs to?
Belongs to the AIM32 family.
Protein: SPR2G_HUMAN
Sequence: MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPYLPPPCPPEHCPPPPCQDKCPPVQPYPPCQQKYPPKSK
What is the function of this protein?
Cross-linked envelope protein of keratinocytes.  It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase.  All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
What are the official names of this protein?
Small proline-rich protein 2G, SPR-2G.
What is the protein family that this protein belongs to?
Belongs to the cornifin (SPRR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTAP_CENSY
Sequence: MLDNAEELSMDTPYGAPSDTITLGGIGGRRLAFIPRHGKKHNIAPHKINYRANIWALQKLGVSRVVAPSAVGSLREELAPGRFVVPSQFLDFTRTREGSFSEDGRVIHISVAEPFCPELRTVLLDAAGDAHDGGTYACIEGPRFSTRAESALFRAAGADIIGMTMVPECQLSREAQMCYASVSTVTDYDAWAEKAVTAKEVLATLADNVERTKALLAKLIPTIPRDRKCTCADALAEAEF
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein: P6_PLRVW
Sequence: MLQSMVQTGPEFLHQGTHLNLEFPAIQELLLTFLRKPIYWRIGMPNTSTLVIPKKMSLLLLL
What are the official names of this protein?
Uncharacterized protein P6, ORF6 protein.
Protein: CMOA_YERP3
Sequence: MPNRDTQSQNDTPRHSPEAAEPQRDSLFAAPIAKLGDWTFDEKVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPNSQIYDLGCSLGAATLSMRRNIKAEGCKIIAVDNSPAMVERCRRHIDAFRAETPVDVVEADILDIKLENASMVVLNFTLQFLEPANRQRLLNQVYQGLRPGGALVLSEKFSFADHNVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKNRLHQAGFEHAEVWFQCFNFGSLIALKAGEAQ
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: HIS4_MYCBT
Sequence: MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQALAAVRD
What is the function of this protein?
Involved in both the histidine and tryptophan biosynthetic pathways.
What are the official names of this protein?
Phosphoribosyl isomerase A, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, N-(5'-phosphoribosyl)anthranilate isomerase, PRAI, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_RICFE
Sequence: MKVVSSLKSLKKRDKDCQIVKRRGKIFVINKKNKRFKAKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: GRE2_YEAST
Sequence: MSVFVSGANGFIAQHIVDLLLKEDYKVIGSARSQEKAENLTEAFGNNPKFSMEVVPDISKLDAFDHVFQKHGKDIKIVLHTASPFCFDITDSERDLLIPAVNGVKGILHSIKKYAADSVERVVLTSSYAAVFDMAKENDKSLTFNEESWNPATWESCQSDPVNAYCGSKKFAEKAAWEFLEENRDSVKFELTAVNPVYVFGPQMFDKDVKKHLNTSCELVNSLMHLSPEDKIPELFGGYIDVRDVAKAHLVAFQKRETIGQRLIVSEARFTMQDVLDILNEDFPVLKGNIPVGKPGSGATHNTLGATLDNKKSKKLLGFKFRNLKETIDDTASQILKFEGRI
What is the function of this protein?
Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG, 2-oxopropanal) to (S)-lactaldehyde as an alternative to detoxification of MG by glyoxalase I GLO1.  MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation.  Also catalyzes the reduction of 3-methylbutanal to 3-methylbutanol.  Acts as a suppressor of 3-methylbutanol-induced filamentation by modulating the levels of 3-methylbutanal, the signal to which cells respond by filamentation.  Also involved in ergosterol metabolism.
What are the official names of this protein?
NADPH-dependent methylglyoxal reductase GRE2, 3-methylbutanal reductase, Genes de respuesta a estres protein 2, Isovaleraldehyde reductase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL6_METST
Sequence: MVKLADITEIIPIPEDVTVTINGSEVTVKGNGGEIKRNFNHNKITISNDEENVTVKVAFPNKKDKAMVGTIRSHISNMIYGVDHGFTYKMKIVYAHFPMTVKVQGKIVTIDNFLGERSPRKAKIIGDDVKVSVKGEDVTITGINKEHVGQTMANIEQATKIKGRDPRIFQDGIYLVDKRQEELE
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ACKR1_BOSIN
Sequence: MGNCLYPVADDNSTKLAIKEDLLIDFPEDYYPDYNETDVEAAAPCHSCSLLNYSSLPFFILVSILGILASGTILYALLRPLFRWQLYQDRSTLVQLAVGSALFSIVVPILARGLSGALITSLCHLAHLVAYGSAFAQALLIGYHACLGPQLGAGQVPGLRLGVTVGLWGVAALLSLPVVLGSDTSQGLCTVTFSGEWETLRYIHAAACFAIFVLLPLGLLGTKGLKTVLGRAPCPWVDVLWVWFIFWWPQGMTLGLDSLVRSKAIVVSTCPAQQALDMLLDVAEALAILHCVATPLLLAWVCYQATHTSPPSLPLPTTQTSHLDTLGSKS
What is the function of this protein?
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.  Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines.  Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC.  May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).
What are the official names of this protein?
Atypical chemokine receptor 1, Duffy antigen/chemokine receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).
Protein: EX7L_VIBC1
Sequence: MLSQTNQNIFTVSRLNAEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSRAQVKCAMFRGNNRRVTFKPANGNQVLVKARLSLYEPRGDYQLIIESMQPEGDGRLQQEFEALKMKLAAEGLFAQTNKQPLPEHPKRVGVITSKTGAALYDILDVLKRRDPSLPVVVYPTMVQGEEAAIQMAQAIGRANSRDECDVLIVGRGGGSLEDLWCFNNEILARTIAASQIPIISAVGHEVDVTIADFVADIRAPTPSAAAELVSRDNSHKDQALVTHQHKLASAMRYYLAQQKQQSAQLMHRLERQHPSYQLQRQTQQLDELEMRLQRAMQRFITTRQQAVERKHHRLQLNSPVKRLAEQKSKLDRVEQKLLDAMDRKLLTMRHQLAIAAEKLDTVSPLATLKRGYSITQTEQGQVVTQAKDVKTGDVLVTRLSDGELRSTVN
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_GEOUR
Sequence: MEEKYLPSRVEEKWQKFWEANKSFRATEDKTREKYYLLEMFPYPSGRIHMGHVRNYSIGDVIARFKRMKGFNVLHPMGWDAFGMPAENAAIQNKSHPAKWTYENIAYMRGQLKKMGLSYDWDRELATCDVDYYKWEQLIFLQMYKKGLAYKKISSVNWCPKCETVLANEQVEDGCCWRCDSNVDQKELEQWSFRITDYAEELLEYTYKLPGWPERVLTMQRNWIGRSTGCEIDFPIEGQMDKIKVFTTRQDTLFGATFMSLAPEHPMALELTTPENMATVAAFIEKVKKTDRIRRTAEDFEKEGVFTGSYCINPVTNRRMPVYLANFVLTDYGTGAVMAVPTHDQRDFEFARKYDIPMGVVIQPEGEALDPQTMAEAFTAEGIMVNSGRFDGLKSGAAKEQIADYLEKEGIGKKTVNYRLRDWGISRQRYWGNPIPMIYCDLCGAVPVPETDLPVVLPMDATFTGEGGNPLDKVDSFVNTTCPQCGEAARRETDTMDTFVESSWYFLRYCCPDFVSGPLDKEKTEYWMSVDQYIGGIEHAVMHLLYARFFTKVLRDLGYCDIDEPFTNLLTQGMVIKDGAKMSKSKGNVVDPNALIDKYGADTARLFSLFAAPPEKDLDWSDQGVDGSFRFLNRVWKLVYDTLPIIGGAGALDPAGLTNEGKGLRRQVHKTIRKVTEDIEERFHFNTAIAATMELVNTIQSFEPKNSPQNAPVLKEAIESVVMLLAPFVPHFTEELWAQLGNNKSLEQAGWPAFDSAAAIDEELLVVVQVNGKLRGKLTVAVTASEDDVKGAALADERVKPFIEGKSVKKIVYVPGKLVNIVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRL1_ALLMI
Sequence: LPICPSGSVNCQVSLGELFDRAVKLSHYIHFLSSEMFNEFDERYAQGRGFITKAVNGCHNASLTTPEDKEQAQQIHHEDLLNLVLGVLRSWNDPLLHLVTEVQRIKEAPDTILWKAVEIEEQNKRLLEGMEKIVGRVQPGDTGNEVYSRWSGLPSLQLADEDSRLFAFYNLLHCGRRDSHKIDNYLKLLKCRLIHDSNC
What are the official names of this protein?
Prolactin-1, Prolactin I, PRL-I.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS16_AGRFC
Sequence: MALKIRLARGGSKKRPYYQIVVADARSPRDGRFLEKVGSWNPMLAKDNPLRVELKADLIKEWIAKGAQPTDRVLRFLAEAGLAERAARSNPEKALPGKRALERVAEKKQKAEDAAAAAAAEASAAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.