PharMolix/UniProtQA huggingface dataset:
Protein: NDK_METC4
Sequence: MANERTFSILKPDATRRNITGAVNAVIEAAGLRIVGQRRIRMTREQAEKFYEVHKERPFFGELVEFMTSGPVVVQVLEGENAVAKYREVMGATNPAQAADGTIRKQFAESVGENTVHGSDSADNARLEIAQFFNDADIAA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB1_THEGJ
Sequence: MNGSPSAMKGTTTVGVVCRDGVVLAADRRATLGNMVTSKEVTKVFQIDDHLAIAGAGLVGDILSLVRLLRAEAKLYRAKVGREMSVKALATLVSNVLHGSRHLPYFAWFLIGGYDVKPRLYSIDAAGGVTEERFIAAGSGMEFALALLEENFSDGMGLDEGIDLAVRAVKAAIRRDVYTGEGVTVVAITKEGYRELEPVLK
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 1, 20S proteasome beta subunit 1, Proteasome core protein PsmB 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JOS1_MOUSE
Sequence: MSCVPWKGDKAKAESSDLPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRETLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKYHLRGKNCELLLVVPEEVEAHQSWRADV
What is the function of this protein?
Deubiquitinates monoubiquitinated probes (in vitro).  When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme.  May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis.  May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).
What are the official names of this protein?
Josephin-1, Josephin domain-containing protein 1.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.
Protein: RIMM_METPP
Sequence: MLDDEVVWPEDAIEVGRIVDAWGIKGGIKVLPFSSDPQALFSSRRWFLRPPEKPMGPKAAKPLPTLLRITNAREQGDVIVATAQDVADRNAAEALRGCSVFVSRASFPTADVDEYYWIDLIGLAVVNREGQALGNVADLLDTGAHSVLRVTQVETDDQGRSLERERLIPFVAAYIDAVSLEQRCITVDWGLDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBTN1_DANRE
Sequence: MVLDKEEGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQMDYEEGQLNGSFETQVQ
What is the function of this protein?
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
What are the official names of this protein?
Rhombotin-1, LIM domain only protein 1, LMO-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: COPG1_HUMAN
Sequence: MLKKFDKKDEESGGGSNPFQHLEKSAVLQEARVFNETPINPRKCAHILTKILYLINQGEHLGTTEATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDVIIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALGLLYHVRKNDRLAVNKMISKVTRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKTTNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDNEVRDRATFYLNVLEQKQKALNAGYILNGLTVSIPGLERALQQYTLEPSEKPFDLKSVPLATAPMAEQRTESTPITAVKQPEKVAATRQEIFQEQLAAVPEFRGLGPLFKSSPEPVALTESETEYVIRCTKHTFTNHMVFQFDCTNTLNDQTLENVTVQMEPTEAYEVLCYVPARSLPYNQPGTCYTLVALPKEDPTAVACTFSCMMKFTVKDCDPTTGETDDEGYEDEYVLEDLEVTVADHIQKVMKLNFEAAWDEVGDEFEKEETFTLSTIKTLEEAVGNIVKFLGMHPCERSDKVPDNKNTHTLLLAGVFRGGHDILVRSRLLLLDTVTMQVTARSLEELPVDIILASVG
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.  In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.  Required for limiting lipid storage in lipid droplets.  Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).
What are the official names of this protein?
Coatomer subunit gamma-1, Gamma-1-coat protein, Gamma-1-COP.
What is the protein family that this protein belongs to?
Belongs to the COPG family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis- Golgi apparatus.
Protein: RS12_STAAT
Sequence: MPTINQLVRKPRQSKIKKSDSPALNKGFNSKKKKFTDLNSPQKRGVCTRVGTMTPKKPNSALRKYARVRLSNNIEINAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGALDTSGVDGRRQGRSLYGTKKPKN
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: COAX_CLOBB
Sequence: MILLVDAGNTNIVLGVYKDKKYIASWRISTEGNKTSDEYSIQIIQLLNLNNLNPEDVKGIIVSSVVPNIMHSLENMLRRCFGQEPIIVGPGIKTGINIKYDNPKEVGADRIVNAVAAFEIYKRPVIIIDFGTATTFCSVTENGDYLGGCICPGLRISADALFERAAKLPRVELEVPKKVICKNTVSSIQSGVLFGYIGQVEYIVKKMKEEMSDGIEPYVIATGGLANLIANETDAIDEVDSDLTLEGLKILYQKNRE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_MYCPA
Sequence: MTAEAPPLGELEAVRPYPDRTGPKGNLVYKLITTTDHKMIGIMYTVTCFAFFFIGGLMALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLLYATPVVFGFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGGLIAASGFIVPGGAADFGWTAYTPLSDAVHSPGAGGDLWITGLIVAGLGTILGAVNMITTVVCMRAPGMTMFRMPIFTWNILVTSILILIAFPILTAALFGLAADRHLGAHVYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIITEIIPVFARKPVFGYTTLVYATLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMWKGQLTFETPMLFCVGFLLTFLLGGLTGVMLASPPLDFHVTDTYFVVAHFHYVLFGTIVFATFAGVYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQHWLGDLGMPRRYADYLPSDGFQPYNVASTVGAFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERLRAEAHVGRAHGPADKDVTRLDDVQVRS
What is the function of this protein?
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Subunits 1-3 form the functional core of the enzyme complex.  CO I is the catalytic subunit of the enzyme.  Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 1, Cytochrome aa3 subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GOG8D_HUMAN
Sequence: MEWKLEQSMREQALLKAQLTQLKESLKEVQLERDEYAEHLKGERARWQQRMRKMSQEVCSLKKEKKHDKYRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGALQAQVEYNQRISLLNEGQKERLREQEERLQEQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQEKLGKERLEAASQQKQQLTAQLSLMALPGEGHGGEHLDSEGEEAPRPMPSVPEDLESREAMSGFMDHLEEKADLSELVEKEELGFFQYYRERCHQKVYHPITKPGGSAKDAAPGGGHHQAGPGQGGDEGEAAGAAGDGVAAGGDYKGHSKFLVTAQNPAHEPSPGAPAPQELGAAHKHGDLCEVSLTDSVEPVQGEAREGSPHDNPTAQPIVQDHQEHPGLGSNCCVPFFCWAWLPRRRR
What are the official names of this protein?
Putative golgin subfamily A member 8D.
What is the protein family that this protein belongs to?
Belongs to the GOLGA8 family.
Protein: PDXH_ECOBW
Sequence: MSDNDELQQIAHLRREYTKGGLRRRDLPADPLTLFERWLSQACEAKLADPTAMVVATVDEHGQPYQRIVLLKHYDEKGMVFYTNLGSRKAHQIENNPRVSLLFPWHTLERQVMVIGKAERLSTLEVMKYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVSLEQIEFWQGGEHRLHDRFLYQRENDAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: EIF3E_DICDI
Sequence: MEYDLTKQICSFLDAHMMLPLINYLKDTQQYQENEINKAMADILSQTGCCDYAINAYESIGRDTAPLQAKKQELVGELNKLKEQCSFVTQYIESKKQQKEQQKELKEQQKEQQKEKDTDKTTPTTTDETTTTTTTAPTTTTTTTTTTITPITVIPFSQLLEKITPEILDSIYRFSKLLFEIGQYGSAREHLEIFLQLSPTHQNKDKRLSALWGILESDILSLNWGQAVGDISPLQDQIDSNGTPVEQLGQRAWLIHRALFVYFYNPESRSSLVDLLLEDKYLNAIQTTCPHILRYLAVAIIVNKKKQQSNVFQRILNALVRVVEQEAYVYRDPITQFISSLFVKFNFEDAQAQLILCEKVLKNDFFLNTCVDEFMENARVCVFETYCNILESIDIDMLCKNLRIDPESSEKWIVEAIRNTRFSAKIDSANNQIKMFTQHNSYRQVMDKTKALFNRGIEMVVGINESRSQQNRKGGDNRKNQRGQNRNQQNQQNQQSNESNETTTTTTTAAAATTTTTTTATPTSA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, eIF3e, Eukaryotic translation initiation factor 3 subunit 6.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAIA_PSEPK
Sequence: MTQLYRIGQIVPSSNTTMETEIPAMLNARQAIRPERFTFHSSRMRMKQVKKEELAAMDAESDRCAVELSDAKVDVLGYACLVAIMAMGLGYHRQSEKRLQQATADNDALAPVITSAGALVEALHVMKAKRIAIVAPYMKPLTELVVNYIREEGFEVQDWRALEIPDNLAVARHDPANLPGIVAGMDLEGVDVVVLSACVQMQSLPAVAKVEAQTGKPVVTAAIATTYAMLKALDLEPIVPGAGALLSGAY
What is the function of this protein?
Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate in the aerobic nicotinate degradation pathway.
What are the official names of this protein?
Maleate isomerase, Maleate cis-trans isomerase, Nicotinate degradation protein E.
What is the protein family that this protein belongs to?
Belongs to the maleate isomerase family.
Protein: LGI3_MACFA
Sequence: MAGLRARRGPAPGLLALSALGFCLMLQVSAKRLPKTPPCPPSCSCTRDTAFCVDSKAVPRNLPSEVISLTLVNAAFSEIHDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWTLSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLSFPAVSAEPFLYSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYHWDPNTTRFTKLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWHQNGFYSHQALHPWHRDTDLEFVDGEGKPRLIVSNSSQAPVIYQWSRTQKQFVAQGEVTQVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHVVVDLSA
What is the function of this protein?
May participate in the regulation of neuronal exocytosis.
What are the official names of this protein?
Leucine-rich repeat LGI family member 3, Leucine-rich glioma-inactivated protein 3.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Synapse, synaptosome. Note=Found in the synaptosomal membrane fraction.
Protein: PG46_MYCBO
Sequence: MSFVIAVPEALTMAASDLANIGSTINAANAAAALPTTGVVAAAADEVSAAVAALFGSYAQSYQAFGAQLSAFHAQFVQSLTNGARSYVVAEATSAAPLQDLLGVVNAPAQALLGRPLIGNGANGADGTGAPGGPGGLLLGNGGNGGSGAPGQPGGAGGDAGLIGNGGTGGKGGDGLVGSGAAGGVGGRGGWLLGNGGTGGAGGAAGATLVGGTGGVGGATGLIGSGGFGGAGGAAAGVGTTGGVGGSGGVGGVFGNGGFGGAGGLGAAGGVGGAASYFGTGGGGGVGGDGAPGGDGGAGPLLIGNGGVGGLGGAGAAGGNGGAGGMLLGDGGAGGQGGPAVAGVLGGMPGAGGNGGNANWFGSGGAGGQGGTGLAGTNGVNPGSIANPNTGANGTDNSGNGNQTGGNGGPGPAGGVGEAGGVGGQGGLGESLDGNDGTGGKGGAGGTAGTDGGAGGAGGAGGIGETDGSAGGVATGGEGGDGATGGVDGGVGGAGGKGGQGHNTGVGDAFGGDGGIGGDGNGALGAAGGNGGTGGAGGNGGRGGMLIGNGGAGGAGGTGGTGGGGAAGFAGGVGGAGGEGLTDGAGTAEGGTGGLGGLGGVGGTGGMGGSGGVGGNGGAAGSLIGLGGGGGAGGVGGTGGIGGIGGAGGNGGAGGAGTTTGGGATIGGGGGTGGVGGAGGTGGTGGAGGTTGGSGGAGGLIGWAGAAGGTGAGGTGGQGGLGGQGGNGGNGGTGATGGQGGDFALGGNGGAGGAGGSPGGSSGIQGNMGPPGTQGADG
What are the official names of this protein?
Uncharacterized PE-PGRS family protein PE_PGRS46.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PE family. PGRS subfamily.
Protein: MUTL_SALA4
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEDIAPAPRHVPENRIAAGRNHFAVPAEPTAAREPATPRYSGGTSGGNGGRQSAGGWPHAQPGYQKPQGEVYRTLLQTPATSPAPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQSPVCAQPLLIPLRLKVSADEKAALQQAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RL16_STAA3
Sequence: MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEFGLQATTTSWITSRQIESARIAMTRYMKRGGKVWIKIFPHTPYTKKPLEVRMGAGKGAVEGWIAVVKPGRILFEVAGVSEEVAREALRLASHKLPVKTKFVKREELGGETNES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: PDE9A_MOUSE
Sequence: MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELIQGVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARNSRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRNNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPVVEETMLRPLWESREHYEELKQLDDAMKELQKKTESLTSGAPENTTEKNRDAKDSEGHSPPN
What is the function of this protein?
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:9624145).  Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP.  Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle.  Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991).  Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable).  In brain, involved in cognitive function, such as learning and long-term memory (PubMed:22328573, PubMed:24746365).
What are the official names of this protein?
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.
What are the subcellular locations of this protein?
Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum. Cell membrane, sarcolemma.
Protein: BDS2C_ANTEL
Sequence: SYQRFLFLVVVASLIATSLAIPKDLEKRGTTCYCGNTIGIYWFAKKTCPSGRGYTGSCGYFLGICCYPVD
What is the function of this protein?
Potently and selectively inhibits voltage-gated potassium channels Kv11/KCNH/ERG.  Acts as a gating-modifier toxin that shifts the voltage-dependence of ERG activation in the positive direction and suppresses its current amplitudes elicited by strong depolarizing pulses that maximally activate the channels.
What are the official names of this protein?
U-actitoxin-Ael2c, U-AITX-Ael2c, U-AITX-Ael1a.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: BRDT_DANRE
Sequence: MSDVKPPQHFTMNGNPPPPEFKNPKKPGRLTNHLQYIEKVVIRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEKVAEMPEEEYEISALTTKGPVKGARKSTIGLKKRPPSPMSEVVFQQTVTVIPPDALHTIPSAPLSAQLTAKLKNGVKRKADTTTPSASSIPSCESSSCVTEPKVLKLFSRRGSGRPIKPPCKDLPESPPQHQVGRRTKLSERLKYCNAILKEMFSKKHSAYAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVFEFRFSKIPDEPKNANPVSSHNRVKKERARSPSSSESSDSESSSPENSSDTEEEDEEERAHRLASLEEQQLKAVREQLQLLTQTPLSKILKRSSSSKSSGCKVCTMMNSLKKPKFNSVLRRKESRACDSEEEMNTLPMSYEEKRQLSLDINKLPGDKLGKVVNIIKAREPLLRDTDPEEIEIDFETLKPSTLRALECYVVGCLRKKKNKPPKKSKIKEKDKDLQHATGEQNSHKKTKIETDGEIKDTTHPSRLSDSSSSSSSSDSSSSDSSSSDSCDSDSGLTEQKTKRKQSKGPGHANKIKKKKYYPVVPLPEQALRQANAEVKDSSSASGVMCQSRPSSLVSETGSKDLFASQHAKHPVEDITAITGIPPLLSPLTSPSAAMPATGSQSTSSSQFEASSPLCLYKDIVLKHADSWTSLGKLATQTPCTIKSSKESFQQFRKVAMEKELTTASRGLVSKHCLTQQPQKAKLECQPSKPEVESAELPLMAAILDTPKAPEPSSVLQNSVDREREMARKREQERRRREAMSGVIDMTMQRDIMATFEKNLE
What is the function of this protein?
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis.  Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time.  In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA.  Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac).
What are the official names of this protein?
Bromodomain testis-specific protein.
What are the subcellular locations of this protein?
Nucleus. Note=Detected on chromatin.
Protein: RL35_LEUCK
Sequence: MPKMKTHRASAKRFKKTANGGLKSASAYTSHRFHGKTKKQRRQLRGTRMMDSTTVKTYAKMLSNI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: APT_LACLS
Sequence: MELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGFIIGCPVAFALGVGFAPVRKPGKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGVVVGCAFLIELDELKGREKIGNYVYKVLMHY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_SHISS
Sequence: MIEADRLISAGTTLPEDGADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATTRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: Y1016_WOLSU
Sequence: MGRAFEYRRAAKEKRWDKMSKLFPKLGKLITIAAKEGGADPEMNAKLRTAITNAKAQNMPKDNIDAAIKRALGKDGVVITEVNYEAKGPHGVLLFIECATDNPTRTVANVKSYINKIGGQLLQNGSLEFMFSHKAVFEFPKSHLHMDREELELVLIDAGLEELDEQEETLYVYGDYTQFGSLSSTLEELKIDVTKASLQRIANTPVEFSEEQLADIEKLIDRIEDDDDVQAVFTNIA
What are the official names of this protein?
Probable transcriptional regulatory protein WS1016.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.