PharMolix/UniProtQA huggingface dataset:
Protein: PSA_KRIFD
Sequence: MSTPFYVSPEQLMRDRADFARKGIAKGRSAIALQYADGILFVAENRSPALHKVAEIYDRMAFAAVGRYNEFENLRIAGVRLADMRGYSYDRRDVTGRALANAYAQTLGAIFSSGGEKPLEVEILVAEVGTTAADDQIYRLTYDGSIADVRGYAVMGGPAEQVADYVGEHYQEGISLAGALRLAVDALGHDSSEVRQLEPDQIEVAVLDRTRTQVRKFKRISDQTLARILSESRPDTAPSPESSAHTEETETVDGGSYESAAGTSAADDAPIAPPEDPDDNRPL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APX_STRGG
Sequence: MRPNRFSLRRSPTAVAAVALAAVLAAGAPAAQAAGAAAPTAAAAAAPDIPLANVKAHLTQLSTIAANNGGNRAHGRPGYKASVDYVKAKLDAAGYTTTLQQFTSGGATGYNLIADWPGGDPNKVLMAGAHLDSVSSGAGINDNGSGSAAVLETALAVSRAGYQPDKHLRFAWWGAEELGLIGSKYYVNNLPSADRSKLAGYLNFDMIGSPNPGYFVYDDDPVIEKTFKDYFAGLNVPTEIETEGDGRSDHAPFKNVGVPVGGLFTGAGYTKSAAQAQKWGGTAGQAFDRCYHSSCDSLSNINDTALDRNSDAAAHAIWTLSSGTGEPPTGEGVFSNTTDVAIPDAGAAVTSSVAVTGRTGNAPAALQVGVDIKHTYRGDLVVDLLAPDGTAYRLKNSSSGDSADNVIATYTVNASSEVANGSWKLRVQDIARQDTGYIDSWKLTF
What is the function of this protein?
An exopeptidase specific for larger hydrophobic amino acids (especially leucine), no cleavage occurs if the next residue is proline (PubMed:8444149).
What are the official names of this protein?
Aminopeptidase S, API, SGAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28A subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MURC_ROSS1
Sequence: MHYHIIGIAGAGMSAIAHILLDQGHTVSGSDVQRNALTEALEQRGALIHDGHDPAWIAGADALVATSAVRDDHVELSAARARGIPVLRRADLWREWSQQRRVVAVAGTHGKTTTTALIALMLTQAGGNPGFLIGGETPDLGIHARWGDPAAPLVVEADEYDRTFLALTPDVAVMTNVEWDHVDIYPSPDNYEAAFRLFTRRVAQPQRLIVCGDDPGALRVANHPDAQQYGIEEAIARNPASCRLAPMDWMAANVRYDGAMTNFDLWRYDRRTFGARLDGTYTMRLVGDHNVRNALAAIAVATLLGVERDAIADALAAYRGARRRFDIKGEANGITIIDDYAHHPTEARATLAAARARFPQRRLVVYLQPHTFSRTQALRDAWADAFDHADVVRIGDVYPARETGDPRTVAHALAGCIRHNDVQAVGNVVEAAATIGGLLRPGDVLLTLGAGDGYRVGELIIDTLRQQN
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_DESPS
Sequence: MKVGIIAAMEEELTLLVDRLDNCEEVQLGHCKYYTGQINGVEVGLMRCGIGKVNAAIGTTLMIDKLKPKCLINTGVAGGFINEMNVGDIVISSSVRHHDADATAFGYELGQIPDMPSEFQADRRLVEMATKVNLKSKARIFEGPVFSGDSFIHTTEQVENILKNFPQIMAVEMEGASIAQTSHLFNIPFVLIRSISDKVRETKSADTYTQSMEESAKNSVQVVFEMVEQLKEGM
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: PIGM_ARATH
Sequence: MSRESENTDDEPSKWMKFRSLLVFSMLLRVFLIVYGEWQDAHMEVRYTDVDYIVFSDAASLMASGESPYKRTTYRYSPLLALLLTPNSFFHRSWGKFLFSASDLLVGWFIHKILKQRKVPEKICTYSVMVWLFNPFTFTIGTRGNCEPIVCAMILWIILCLMQGNLLQAAFWYGLVVHFRVYPIIYALPIILVLDTQVFRSGQKPALLYWNTGQAKTPASNMERKTFLFNLLTTLKSLFSRERIMFALISGGVFLACNAVSFYFYGQEFLHEALLYHLTRTDPRHNFSIYFYHIYLHYERQFSAVEKLISFLPQFTVQFALVFCFSQDLVFCIFLQTVAFVTFNKVITAQYFVWFYCLLPLILPWSHMKLKWEGLLCIIMWIGAQTHWLLWGYMLEFKGVNVFLPLWIASLLFLAANTFVLVRIIQRHRFSPLFRRYESSSSSNNVTKED
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
What are the official names of this protein?
GPI mannosyltransferase 1, GPI mannosyltransferase I, GPI-MT-I, Phosphatidylinositol-glycan biosynthesis class M protein, PIG-M, Protein PEANUT 1.
What is the protein family that this protein belongs to?
Belongs to the PIGM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NDST1_XENLA
Sequence: MSLSLKTRRFGRPVRPQLVLLLLFALCLLSVFISAYYLYGWKRGLEPSGSEAQSPDCDEPKISPSRLLPVKPLKPVDSSRTDPLVLVFVESLYSQLGQEIVAILESSRFKYRTEIAPGKGDMPTLTDKDRGRFALIVYENILKYVNLDAWNRELLDKYCVEYGVGIIGFFKANENSLLSAQLKGFPLYLHSNLGLKDCSINPKSPLLYITRPNQVEKGDLPGEDWTVFQSNHSTYEPVLLAKTKSAESIPHLSVDAALHTTVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVSFLTGKRLSLPLNRYVLVDIDDIFVGKEGTRMKVEDVKALYDTQMELRTHIPNFTFNLGFSGKFFHTGTDAEDEGDDLLLSYVKQFWWFPHMWSHMQPHLFHNQSVLAEQMALNRKFAVDHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQIWGIKVTSTEEYPHLKPARYRRGFVHNGIMILPRQTCGLFTHTIFYNEYPGGPVELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKLLVQFLNTWTNLKLETLPPVQLAHKYFQIFPEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHSDLSSNYPSSETFEEIQFYNGQNYHKGIDWYMEFFPIPSNTTSDFYFEKSANYFDSELAPRRVAALLPKAKIITILINPADRAYSWYQHQRAHDDPVAIKYTFQEVIKAGPEAPQRLRALQNRCLVPGWYSTHIERWMNHFHANQILVLDGKLLRTEPANVMETVQKFLGVTNAMDYHKTLAFDPKKGFWCQLLDGGKTKCLGKSKGRKYPDMDSDSRSFLMDYYRDHNIELSKLLYKMGQTLPTWLREELQNTR
What is the function of this protein?
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate.  Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.  Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
What are the official names of this protein?
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, Glucosaminyl N-deacetylase/N-sulfotransferase 1, NDST-1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family. NDST subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein.
Protein: DNLJ_DESAH
Sequence: MIDPSSSFDRIKKEARLLREQLHVHNINYHVKDDPVISDGEYDRMMQRLIAIETQFPELSTPDSPTRRIGAKALTAFETAEHAIPMQSLDNAFSDQDVIDFHNRTAKILNTSDIRYTVEPKLDGVAVELRYEQGSLTLALTRGDGTMGEVITDNARTIPSVPLKLAPAGNGTIPDVLEVRGEVIINSKDFEGLNKKRLATGEPLFANPRNAAAGSLRQLDSRVTAKRPLEIFVYGVGRAQELMANFDIGSHSALLESLKRLGFRINPLIRSGLSLTEVLDRFKAFETMRQDLDYEIDGMVIKVDDIVFQERLGTKARSPRWAIAYKFPAMEETTVINDIIVQVGRTGTLTPVAILEPVNIGGVMVARASLHNQDEIQNKDIRINDTVLVKRAGDVIPKVVKPVTALRTGSERVFVMPTHCPVCHSPVRRLDNEAAVKCINASCKAQLKQRLKHFVSKGGFDMEGLGTKLIDQLVDRTLVGSFADLFTLDRETLAAMDRMGEKSATNIVQAIERSKRIPLKRFLFALGMAHTGESAAQLLSSTFFTLEALLKASAEALGAIEGVGPKTADSVVAFFANPDNQETIARMMENGVVIENHTVVESAALDNATFFSEKRVVLTGTLGTLTRSEAKQRLEEQGARVVSSVSKNTDILVAGEASGSKLVKARSLGVTIMDEQTFLEHLDRG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: YTFE_SALTY
Sequence: MAYRDQPLGELALSIPRASALFRQYDMDYCCGGKQTLARAAARHDVDIDIIEAQLAQLAEQPIEKDWRAVPLADIIDHIVVRYHDRHREQLPELILQATKVERVHADKPNVPRGLTKYLTALHEELSSHMMKEEQILFPMIKQGMGRQATGPISVMESEHDEAGELVDVIKHVTKNVTPPPEACTTWKAMYNGINEMIDDLMEHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_ORYLA
Sequence: MAQRRFFVGGNWKMNGNKESLEELMSTLNTASLHEDTEVVCAAPSIYLDFARSGLDSRISVAAQNCYKVAKGAFTGEISPAMIKDCGADWVILGHSERRHVFGENDELIGQKVAHALESDLSVIACIGEKLEEREAGTTEDVIFAQTQVIAENVMDWEKVVLAYEPVWAIGTGKTATPEQAQEVHEKLRAWFRANISEEVSDSLRIIYGGSVTAANCRELASQTDVDGFLVGGASLKPEFIDIINARA
What is the function of this protein?
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
What are the official names of this protein?
Triosephosphate isomerase, TIM, Methylglyoxal synthase, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNCB_ACIBT
Sequence: MSPIIHSLLDTDLYKFTMLQVVLHKFPQTHSVYHFRCRNLEDTVYPLVDILDDLNEQLDHLCNLKYKEDELQYLRKLRFIKSDFVDYLELFQLKRRFIHASIDEEGRLDIRIEGPMVQAMMFEIFVLAIVNELYFSRIKTDEVWAEGERRLQAKLELIQQYEKAQQPNDPPFLVSDFGTRRRYSFEWQKHVVAAFHNTVPNVFRGTSNVLLAKELNITPIGTMAHEFLQAFQALDVRLRDFQKAALETWVQEYRGDLGIALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYEWGDKAYAHYRKLKIDTKTKMLTFSDGLNLPKAWELHQYFKDRFQVSFGIGTNLTNDMGQTPLNIVLKLVECNGQSVAKISDSPGKTMTDNDTFLAYLRQVFQIEELDEAI
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: COMP_RAT
Sequence: MSPTACVLVLALAALRATGQGQIPLGGDLAPQMLRELQETNAALQDVRELLRHRVKEITFLKNTVMECDACGMQPARTPGLSVRPVALCAPGSCFPGVVCTETATGARCGPCPPGYTGNGSHCTDVNECNAHPCFPRVRCINTSPGFHCEACPPGFSGPTHEGVGLTFAKTNKQVCTDINECETGQHNCVPNSVCVNTRGSFQCGPCQPGFVGDQRSGCQRRGQHFCPDGSPSPCHEKADCILERDGSRSCVCAVGWAGNGLLCGRDTDLDGFPDEKLRCSERQCRKDNCVTVPNSGQEDVDRDRIGDACDPDADGDGVPNEQDNCPLVRNPDQRNSDKDKWGDACDNCRSQKNDDQKDTDRDGQGDACDDDIDGDRIRNVADNCPRVPNFDQSDSDGDGVGDACDNCPQKDNPDQRDVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQQDSDHDGKGDACDDDDDNDGVPDSRDNCRLVPNPGQEDNDRDGVGDACQGDFDADKVIDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTATDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTASQVRLLWKDPRNVGWKDKTSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTAMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYERHRLRRA
What is the function of this protein?
Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin.  Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors.  Could play a role in the pathogenesis of osteoarthritis.  Potent suppressor of apoptosis in both primary chondrocytes and transformed cells.  Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity).  Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli.  Maintains this phenotype of VSMCs by interacting with ITGA7 (PubMed:20019333).
What are the official names of this protein?
Cartilage oligomeric matrix protein, COMP.
What is the protein family that this protein belongs to?
Belongs to the thrombospondin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: DPO3_STRSY
Sequence: MSDKFQLLLQQIGMPLDARQSGAFSTATIEKVVLHKVSKLWEFTFRFETPLPLMDYQLFKARLATEFEKVGNKIQFSIVSDAEAFEAGLVEAYYPEAFTEDLCQSAGFKALFQPLEVAYRDGVLWIKGPETIDTDHFRKNHLPNLVEQYKRFGFGNLAVDIQVCQEMTQQQAEIFHAQNAEIYQQANEENLAALEQLAQMAPPPEAAQPFVPEYKKNRPAKVNIEKAEITPMIEVDSEENRIVFEGLVFEVEQKTTKTGRVIINFKMTDYTSSFTLQKWAKNEEEAQKFDMVKKGNWLRVRGNVETNNFTRDLTMNVQEVQEVKKEIRKDLMPEGEKRVEFHAHTNMSTMDALPAVEDLVARAAAWGHKAVAITDHGNVQSFPHGYHAARKAGIKPLFGMEANIVEDSVPIAYNEADVVLSDATYVVFDVETTGLSAVNNALIQIAASKMHKGNIIAEFDEFIDPGHPLSQFTTDLTGITDEHVRGSKPLEQVLREFQDFCQDSVMVAHNATFDVGFMNVNYERAGLPIISQPVIDTLEFARNLYPDFKRHGLGPLTKRFGVALEHHHMANYDAEATGRLLFIFLKDALEKHNLTNLNQLNTELIAEDSYKKARVKHATLYVINQVGLKNMFKLVSLSNTKYFEGVPRIPRTVLNAHREGLILGTACQEGEVFDDLLSKGIDEAVKTAAYYDFIEVMPPALYAPMIAKEQFKDMAEIEETIKQLIEVGRRAGLPVLATGNVHYIDPEEEIYREIIVRALGQGAPINWTIGNGENAQPAPLPKAHFRTTSEMLDEFAFLGESLAREIVITNPNAMLDRFEDVQVVKTDLYTPYIEKAEETVAELTYQKAFEIYGNPLPDIIDLRIEKELTSILGNGFAVIYLASQMLVHRSNERGYLVGSRGSVGSSFVATMIGITEVNPMPPHYVCPNCQHSEFITDGSYGSGFDLPDKDCEKCGTKYKKDGQDIPFETFLGFDGDKVPDIDLNFSGDDQPSAHLDVRDIFGEENAFRAGTVGTVAAKTAYGFVRGYERDYGKFYRDVEVERLAAGAAGVKRTTGQHPGGIIVFPDYMDVYDFTPVQYPADDVTASWQTTHFNFHDIDENVLKLDILGHDDPTMVRKLQDLSGIDPQTIPADDKGVMALFSGTEILGVTPEQIGTPTGMLGIPEFGTNFVRGMVEETKPTTFSELLQLSGLSHGTDVWLGNAQDLIKAGIANLSTVIGCRDDIMVYLMHAGLPPKMAFNIMERVRKGLWLKISEEERNGYIQAMKDNKVPDWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPLYYYCAYFSIRAKAFDLATMSGGLERVKAKMEEIALKKKNNEASNVEQDLYTTLELVNEMLERGFKFGKLDLYKSHATDFLIEEDTLIPPFVAMDGLGENVAKQVVAARAEGEFLSKTELRKRGGLSGTLVEKMDEMGILGKMPEDNQLSLFDDLF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBK_OENEH
Sequence: MLNIFSLICLNSDLYSSRFFLAKLPEAYAFLNPIVDVMPVIPLFFLLLAFVWQAAVSFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HIS6_HALSA
Sequence: MTLTKRVIPCIDVDLDDDGEPAVYTGVNFEELAYTGDPVEMAKRYNEAGADEFVFLDITASAEGRETMLDTVSAVADEVFIPLTVGGGIRDTDDIRETLRAGADKVSINSGAIADPSLVDRGAKAFGSQCIVISVDARRRFDEQGQHYTQVDGESCWFECTVHGGREGTGMDAIEWVQEAQRRGAGELFVNSIDADGTQDGYDVPLTAAVCDAVSTPVIASSGCGAPGDMADAYDAGADAALAASIFHFDEYSIAETKETLADAGYPIRAPDA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METL8_MOUSE
Sequence: MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRALFI
What is the function of this protein?
Stimulates adipogenesis.
What are the official names of this protein?
tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial, Methyltransferase-like protein 8, Tension-induced/inhibited protein, mRNA N(3)-methylcytidine methyltransferase METTL8.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METL family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Nucleus. Note=Mitochondrial protein (By similarity). The cytoplasmic or nuclear localization observed by some groups is either the result of an incorrect localization caused by N- terminal tagging that interferes with mitochondrial targeting, or splice isoforms that lack the N-terminal mitochondrial transit sequence (By similarity). SUBCELLULAR LOCATION: [Isoform 5]: Nucleus. Note=Isoform 5 localizes to the nucleus upon cell stretch in embryonic lung progenitor cells.
Protein: IXTPA_HYDS0
Sequence: MKLMICTSNKKKFEEISSILESLKKDENLDLEFVKPPKEIEVEEYANTFLSNAYLKAKAYYNAFGIPALADDSGLVVEAFSDNLERPGVYSARFYKDSFGSHVLKEEDFKLSKDELNNLKVLRLLEKEENRKAKFVSVVAIVLSNNYGIFGEGELKGHIAKEPFGNFGFGYDPIFIPEGYNTTLANIENKDKISHRRQALEAVFFMLKKML
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: RL9_CLOB6
Sequence: MKVILLKDVKSLGKKGDLVNASDGYARNYLIPKKLAEQATENNVHILNNKKEAERRQKLKELEEAQKLAKSLMGKEIKFKVKIGENGRLFGSITSKDISEKLKEQYNMDIDKKKIVAETIRQTGVYEAEIKIYPEVSTKVKVSVLEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: HLDE_MAGSA
Sequence: MTELSALVERVEKLRGTMVLCVGDAMLDRFVYGSVERISPEAPIPVLCIERETAMLGGAGNVVRNLVAVGAEPAFVSVVGDDTAGREVTRLVGEHGEIDPCIVVEPGRQTTIKTRFFASHQQLLRADRESRSPVGEAIRAQLLTRIERLLPKAGVMVLSDYGKGVLAEPIAIELIRRAKAAGKQVIVDPKGTDYTIYAGATVVTPNRKELHEATGQAVDSDEQVVAAARQLIDSCGFEAVLVTRSQDGMTLVRADGQIDHLPAEAREVFDVSGAGDTVVATLAAALASGATLPEAAHLANVAAGIVVGKVGTAVAYGDELVVALHREDLTLGEAKIVPVTAAAEVVDRWRRKGQKVGFTNGCFDLLHPGHVSILAQAKGACDKLVVGLNSDASVQRLKGPTRPVQSEASRATVLSSLATVDLVVIFGEDTPLEVIGTLKPDVLVKGADYTIDKVVGADLVQSWGGKVVLAELVNGQSTTNTIKKMNGN
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: COX2_MYCLE
Sequence: MTARELVCSQRVGQGLSRRLRPLVLAVTLGVLVVTLSGCSWSDALAIGWPEGITPEAHLNRQLWIGAVVASLVVGVIVWGLIFWSTIFHRKKTTDTELPRQFGYNMPLELVLTVTPFLIISMLFYFTVIVQDKMLYLAKDPEVVIDVTAFQWNWKFGYQRVDFKDGTLTYDGVDPARKKAMVSKPEGKDSHGEELVGAVRGLNTEDRAYLNFDKVETLGTTTEIPVLVLPAGKRIEFQLNSADVVHSFWVPKFLFKRDVMPNPVANNSVNVFQVEEITKTGAFVGHCAEMCGTYHSMMNFEVRVVAPNDFKAYLQQRIDGKTNAEALQVIAQPPLAVTTHPFDTRRGQLTNSQ
What is the function of this protein?
Subunits I and II form the functional core of the enzyme complex.  Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 2, Cytochrome aa3 subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYY_AMOA5
Sequence: MYDFIANLRWRGMIHDITPGLEAQLQKEMITGYIGFDPTAPSLHVGNLATIMLLKHFQLAGHKPIAVVGGATGMIGDPSFKSTERKFLSEEELLHNQSCIMKQLKCFLDFSSSANTAELLNNIDWFKDFGFLRFLREVGKHISINYMMAKESVKRRLEDGISFTEFSYQLLQGYDFYYLYNTKGVKLQMGGADQWGNLTTGIELIRRKTGEEAFALTAPLITKADGTKFGKSEQGNIWLDSTMTSPYEFYQFWLNCTDEDACRLIKVFTLLSKEEIDNLIELHVQAPHQRILQKQIAKELTIRVHSETDYMQARKTSELLFGHATAEDLWELSEKDFKVIFKSIPEVHITLTQLTEAEHMLDLVASTGFGIMFNSKGEVRRAIQEGSLSVNKEKITDPLQKPNLKLLQDKYLLVQRGKKHHYLIKVS
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1C_PINTH
Sequence: MKKQNLIHAEGLVTESLPNGMFRVLTDNGCQILTHISGRIRRNSVRILPGDRVKVELSAYDLTKGRIIYRLSNKSSND
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YQGF_FRAP2
Sequence: MFQSLIAIDYGKARIGLASGQMITKTATPIGTVEAYDGVPNWIELDKIVKRWNPSDIVIGLPLDTQDFETDITKAAKDFAKEVKERYKRNVHLINEAYSTREARWRLEEVKSKKVSHIKVDALAACVILETWMAEN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_YERPG
Sequence: MAKGVREKIKLVSSAGTGHFYTTTKNKRTKPEKLELKKFDPVVRQHVLYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RPIA_LISMO
Sequence: MINQKKIAGEKACEWIKDGMVVGLGTGSTVYYTIEKLGEMVNNGLHITGVATSEETNKQAQNLGIPLKSLNDVTEIDITIDGADEIDTDFQGIKGGGGALLREKMVASASLKNIWVVSEEKLVRNLGKFPLPLEVIPFGWKQVERKLEKEHIQTNLRKQSSGEVYVTNNGNYILDIVNQTFTDAEMWQEKLAQIPGIVEHGLFLHYVDIIICAKANGEIELIKK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: CLC10_MOUSE
Sequence: MIYENLQNSRIEEKTQEPGKAPSQSFLWRILSWTHLLLFSLGLSLLLLVVVSVIGSQNSQLRRDLGTLRATLDNTTSKIKAEFQSLDSRADSFEKGISSLKVDVEDHRQELQAGRDLSQKVTSLESTVEKREQALKTDLSDLTDHVQQLRKDLKALTCQLANLKNNGSEVACCPLHWTEHEGSCYWFSESEKSWPEADKYCRLENSHLVVVNSLEEQNFLQNRLANVVSWIGLTDQNGPWRWVDGTDFEKGFKNWAPLQPDNWFGHGLGGGEDCAHITTGGPWNDDVCQRTFRWICEMKLAKES
What is the function of this protein?
Recognizes terminal galactose and N-acetylgalactosamine units.  May participate in the interaction between tumoricidal macrophages and tumor cells.  Plays a role in the recruitment of inflammatory monocytes to adipose tissue in diet-induced obesity.
What are the official names of this protein?
C-type lectin domain family 10 member A, MMGL, Macrophage asialoglycoprotein-binding protein 1, M-ASGP-BP-1, Macrophage galactose/N-acetylgalactosamine-specific lectin.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.