PharMolix/UniProtQA huggingface dataset:
Protein: KLH20_HUMAN
Sequence: MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCESHIW
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport.  The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280).  The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539).  Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539).  Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases.  The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212).  In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).
What are the official names of this protein?
Kelch-like protein 20, Kelch-like ECT2-interacting protein, Kelch-like protein X.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon. Cell projection, dendrite. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN- gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (PubMed:20389280).
Protein: SYH_CLOBM
Sequence: MSLQAPKGTKDLLPTESYKWQYLENKFRNIAADFGCREIRTPVFEYTELFQRGVGETTDVVQKEMYTFEDKAGRSITLKPEGTSPAVRAFVEGRLFNETQPTKMYYFTPVMRYENVQKGRLRQHHQFGIEIFGAKDASVDAEVISIPVGIYKELGVEGVELNINSIGCPKCRKTYNEALKKYLSKNYDKLCSTCKTRFDKNPLRILDCKVDTCKEIVKDAPIILDYICDECRDHFEALKSYLDVLDIKYKVDPFIVRGLDYYSKTVFEFIIDDITICAGGRYDYLIEEIGGPSMPAVGFGMGIERLLLTLQEKAIEIPEEAYVDLYLGNMGDKAKLEVLKLAKELRDRHIKCEIDHMGKSVKAQMKYANKIGAKYSMVLGEEELNTGKVALKRMEDGQQIEVDIKEIDTLIKVFK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_STRP8
Sequence: MDTKTLIASEIAKVVPELEQDAIFNLLETPKNSDMGDLAFPAFSLAKVLRKAPQMIASELAEQIDESQFEKVVAVGPYINFFLDKAKISSQVLEQVITAGSDYAQQDEGQGRNVAIDMSSPNIAKPFSIGHLRSTVIGDSLAHIFAKMGYQPVKINHLGDWGKQFGMLIVAYKKWGDEAAVQAHPIDELLKLYVRINAEAETDPTIDEEAREWFRKLEDGDKEATELWQWFRDESLLEFNRLYDQLHVTFDSYNGEAFYNDKMDEVLDLLEAKNLLVESKGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKRTYDFAKSVYVVGNEQAAHFKQLKAVLKEMGYDWSDDMTHVAFGLVTKGGAKLSTRKGNVILLEPTVAEAINRAASQIEAKNPNLADKEAVAHAVGVGAIKFYDLKTDRMNGYDFDLEAMVSFEGETGPYVQYAHARIQSILRKADFTPSATTTYSLADAESWEIIKLIQDFPRIIKRTSDNFEPSIMAKFAINLAQSFNKYYAHTRILDDNSERDNRLALCYATATVLKEALRLLGVDAPNEM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_RHIWR
Sequence: MTVPLDRIRNFSIIAHIDHGKSTLADRLIQRTGGLTDREMSAQVLDNMDIEKERGITIKAQTVRLDYKAKDGQDYVLNLMDTPGHVDFAYEVSRSLAACEGALLVVDAAQGVEAQTLANVYQSIEHDHEIVPVINKIDLPAAEPDKVKAEIEDIIGLPADDAVLASAKSGIGIDEILEAIVARIPAPKGDPAAPLKAMLVDSWYDPYLGVVILIRVVEGTIRKGQQIKFMQADTVHLVDRVGCFRPKIEQLGEMGPGEIGFITAQIKEVSQTAVGDTITDARKPTAEPLPGFKEVQPVVFCGLFPVDAADFEKLRESLYKLRLNDASFSFEAESSAALGFGFRCGFLGLLHLEIIQERLTREYDLDLITTAPSVVYRLHLSHSKTEDAKVIELHNPADMPDPNRIDMIEEPWIEATIYVPDEYLGSLLKLCQDRRGIQKNLTYVGGRAQITYELPLNEVVFDFYDRLKSISRGYASFDYHQIGYREGDLVKMSIMVNGEPVDALSMIVHRAAAEARGRHMCERLKDLIPRHLFKIPVQAAIGGKVIARETIAAMRKDVTAKCYGGDATRKRKLLEKQKEGKKRMREYGNVNIPQEAFIAALRMGDEG
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MURI_SALPA
Sequence: MATKLQDENTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRRLLPDLHYIYAFDNVAFPYGEKSETFIVERVVEIVTAVQQRYPLSLAVIACNTASTVSLPALREKFAFPVVGVVPAIKPAARLTANGVVGLLATRATVKRPYTHELIARFANECQIAMLGSAELVELAEAKLHGDSVSLEELRRILRPWLRMPEPPDTVVLGCTHFPLLRDELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSTDANIAYCMAMTPGAEQLLPVLQRYGFETLEKLAV
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: ZWINT_MOUSE
Sequence: MADAEKNAVAEKNNAVATKEVLAEAAAILEPVGLQEEAELPAKIMEEFMRNSRKKDKLLCSQLQVVNFLQTFLAQEDTEQSPDALASEDASRQKATETKEQWKDMKATYMDHVDVIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISEGKAEDKDVKGRALTAKSKSP
What is the function of this protein?
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity.  Required to target ZW10 to the kinetochore at prometaphase (By similarity).
What are the official names of this protein?
ZW10 interactor, ZW10-interacting protein 1, Zwint-1.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
Protein: Y1603_BRUO2
Sequence: MLYYVLVFLVVALVAGALGFGGIAGASAGIAQILFFVFLALLVISLIASAIRKA
What are the official names of this protein?
UPF0391 membrane protein BOV_1603.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DXS_FRATH
Sequence: MSKYTILDKINTPSDLKLIPESQLKILSAELRAFLVDTLDVSGGHFASSLGATELTVALHYVYNAPYDNIVWDVGHQTYIHKILTGRKDKLVTIKKDGGISGFPKRSESEYDTFGVGHSSTSISAALGMAIADRLQGKSSNTVAVIGDGAITGGMAFEALNHAGGIKEDILVILNDNEMSISDNVGGLSAHFSKIISGGFYNSIREKGKEVLKNIPPIFEFVKKIETQTKGMFVPANFFEDLGFYYVGPIDGHDVTELVKTLRILKDHKGPKLLHVITKKGKGYTKAESDPIKFHHVAPSFHSGENITTKISKPTYSNIFGDWICQKAAKDKRLVGITPAMKEGSDLIRFSQLYPHRYFDVAIAEQHAVTFAGGLACQGLKPVVAIYSTFLQRAYDQVIHDIALQNLDVLYAVDRAGLVGADGATHDGSFDLAFMRCIPNHVIMTPSDENETYHMLEFGYEYNGPAMVRYPRGAGIGAEITGSLDLELGKAKIVKQGSKIAILNFGTLLPLAKQLAEKYHATVIDMRFVKPLDKIMLDKVSQTHEIILTLEENCIAGGAGSAVNEYFVAKDLSNKIIVRNFGLQDKFLNHGTKDLLLAQSKLCVENISKELDKLI
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: AMPA_RHOPS
Sequence: MPDAVKVGFVPFSAAARGTLVVFCDDTLKFGSVTGKALGAAASTVKRAVAASQFKGKSGSALDLLAPEGLKVGRLIVIGTGKAAALKDNDIVKLGGAVAGKLSTGDSAVTVIAELPGGAMRPEQAAAVASGIRLRAYKFDRYKTKKKDDDADAANANVSIAVADVAAAKKAFAPDSHVVDGVILARELVNEPPNVLYPEEFAKRAAQLRKLGVQVEILDVKAMTRLKMGALLGVSQGSAHPGRTVIMRWNGGKRGAQPVAFVGKGVCFDTGGISIKPSASMEDMKGDMGGAACVVGLMHALAARKAKINVIGAIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVAQKHKPKFMVDLATLTGAIMVALGTDHAGLFSNNDELAERLTAAGLSTGERVWRMPLGPEYDKQIDSQFADMKNTGSRNGGSITAAQFLQRFVDNTPWAHLDIAGTAMGAPKSDINHSWGSGYGVRLLNALVAEHYEAKK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FWDG_METKA
Sequence: MVKIVIHEERCHGCGNCVIACPVNACNSPNVWGGKGPEDGEDVVIKVVNGTVSVINEDLCEACMTCELACPVDAIEIKT
What is the function of this protein?
Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR).  This enzyme is oxygen-labile.  May function as an electron transfer protein.
What are the official names of this protein?
Tungsten-containing formylmethanofuran dehydrogenase 2 subunit G, Tungsten-containing formylmethanofuran dehydrogenase II subunit G.
Protein: RL31_HELHP
Sequence: MMKKGIHPEYIPCKVTCVTSGKQLEVLSTKSELRIDISSFCHPFYTGSDKITDITGRVEKFRQKYNMK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: CARB_GEOSE
Sequence: MPKRRDIETILVIGSGPIVIGQAAEFDYAGTQACLALKEEGYKVILVNSNPATIMTDTEIADKVYMEPLTLDFVARIIRKERPDAILPTLGGQTGLNLAVELAKAGVLEECGVEILGTKLEAIEKAEDREQFRALMNELGEPVPESAIIHSLEEAYAFVEQIGYPVIVRPAFTLGGTGGGICTNEEELVEIVSTGLKLSPVHQCLLERSIAGYNQIEYEVMRDANDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNASLKIIRALGIEGGCNVQLALDPDSFRYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMINPVTGKTYACFEPALDYVVTKIPRFPFDKFESANRRLGTQMKATGEVMSIGRTFEESLLKAVRSLEIGVHHLELNEAKTAADDVMEKRIRKAGDERLFYIAEALRRGVTVETLHEWSQIDRFFLHKIQNIIEMETVLKNHPGDLDVLKKAKGLGFSDAAIAALWNKTERDVYALRRQEGIVPVYKMVDTCAAEFTSETPYYYSTYEEENESIVTEKPSVIVLGSGPIRIGQGIEFDYATVHCVLAIKQAGYEAIIINNNPETVSTDFSTSDKLYFEPLTAEDVMHVIDLEQPVGVIVQFGGQTAINLAAELEARGVRLLGTTLEDLDRAEDRDKFEQALSELGIPKPAGKTAVSVEEAVAIAEEIGYPVLVRPSYVLGGRAMEIVYNREELLHYMEHAVRVNPQHPVLVDRYITGKEVEVDAIADGETVVIPGIMEHIERAGVHSGDSIAVYPPQTLSDDVIAKITDYTVKLARGLHIVGLLNIQFVVAGSDVYVLEVNPRSSRTVPFLSKITGVPMANLATKAILGAKLADMGYETGVCPVRPGVYVKVPVFSFAKLRNVDISLGPEMKSTGEVIGKDVTFEKALYKGLVASGIQIQPHGAVLLTVADKDKEEAVELARRFADIGYQLLATNGTAETLKAAGIPVTVVNKIHSASPNILDVIRQGKAQVVINTLTKGKQPESDGFRIRREVENGIPCLTSLDTARAMLQVLESMTFSTTAMTEGLVRS
What are the official names of this protein?
Carbamoyl-phosphate synthase pyrimidine-specific large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: SYK_CAMJR
Sequence: MFDNILEQQRIEKAKELKNLGINPYPHFLEKEMSLKTFKDRFSYILEQVEKRDESVNAVVAGRLKLLRIAGKSIFANIEDEDTNLQIYFSKDSVGEELYTILKKNLEVGDIVLVKGFPFVTKTGEFSLHASEVKLATKAIVPLPEKYHGLTDIEQRYRKRYVDMIMNAEVRKDFLVRSKVVSLIRHFFENKGFLEVETPMMHPIAGGANAKPFVTFHNSLGVERFLRIAPELYLKRLVVGGFEAVFEINRCFRNEGMDLTHNPEFTTIEFYWAYHNYKDLMDLTEELFALLLDKLNLGKTIEFDGKMIDFSKPFERITYKDALCKYGGLDRDLIEDKEKILTKLKADGFEANEKLELGHLQAELFDNYVEEKLINPTFVIDFPISISPLSRRSDEDSQIAERFELFICGRELANGFNELNDPLDQYERFLKQIEAKNAGDEEACEMDEDFVNALGYGMPPTAGQGIGIDRLVMLLTNKKSIRDVILFPAMRPLKSELKEKE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_STRGC
Sequence: MKDRYILAFETSCDETSVAVLKNETELLSNVIASQIESHKRFGGVVPEVASRHHVEVITVCIEEALAEAGISEEQVTAVAVTYGPGLVGALLVGLAAAKSFAWAHDIPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSQAGDYKIVGETRDDAVGEAYDKVGRVMGLTYPAGREIDQLAHQGRDMYDFPRAMIKEDNLEFSFSGLKSAFINLHHNAQQKGEALSNQDLSASFQAAVMDILMAKTKKALEKYPVKTLVVAGGVAANQGLRERLAAEIQDVKVIIPPLRLCGDNAGMIAYASVSEWNKKNFAGLDLNAKPSLAFETME
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_ARTS2
Sequence: MRRAVCPGSFDPIHNGHLEVIARAAGLFDEVIVAVSTNYAKKYRFPLEERIDMARETLASLRGIVVEPVGEGLLAEYCRQRGVSAIVKGLRSSSDFDYELPMATMNRQLSGVETVFLPTEGHYLHLSSTLIKEVFTLGGNVSDYVPRSVLKRLLAGESS
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1M_ASTFO
Sequence: MLLLFLNSVGFIVPVLLAVALLTLIERKMLGYMHVRKGPNNVGPYGLLQPIADGFKLLIKETLKPSNASPYLFYSSPALFLFLAILLWSIIPVGESTLNFNLSLVLILGLSSLSVYSLLGSGWSSNS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SPP2_SCHPO
Sequence: MKRKAVLEAFSDSEDEDEKKLKGPQLITGFSAEEGVHYQNETIQRIHEKKRAPKIIHIASDENWMEKRKARFKKKETEVHEKPSQLPDSGLNYGLNIRVASSSAADNEIVDWKANNSNEKAQNKIATNKESTDILPEEVQLVLNDLNDDVKSANSANLQPITTNVVNEKDAYRKDIDELPEPSNMKDYSEIPVEEFGAAMLRGMGWNGQLSSKDAFDVNQRPTFLGMGAKPVDSELTELDIWKNPKKTMFLPVKPLESNSALNSQNEHTEVQKKSNSIDNLTPSSELFRKRSRDNNLSRESSVSSKHLDYNSRNYNKRDRDPDRTKYREYHSERRKQHRTDRYSDDYYQGRSYSYKKRSHRSDRYTERENPDRSYRSTRTL
What is the function of this protein?
Involved in spliceosome maturation and the first step of pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor cwf28, Complexed with cdc5 protein 28.
What is the protein family that this protein belongs to?
Belongs to the SPP2 family.
Protein: LR75A_HUMAN
Sequence: MGTRQTKGSLAERASPGAAPGPRRERPDFWASLLLRAGDKAGRAGAGMPPYHRRVGMVQELLRMVRQGRREEAGTLLQHLRQDLGMESTSLDDVLYRYASFRNLVDPITHDLIISLARYIHCPKPEGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRKPQACLKAVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRLTTLALNGNRLTRAVLRDLTDILKDPSKFPNVTWIDLGNNVDIFSLPQPFLLSLRKRSPKQGHLPTILELGEGPGSGEEVREGTVGQEDPGGGPVAPAEDHHEGKETVAAAQT
What are the official names of this protein?
Leucine-rich repeat-containing protein 75A, Leucine-rich repeat-containing protein FAM211A.
What is the protein family that this protein belongs to?
Belongs to the LRRC75 family.
Protein: MDM1_HUMAN
Sequence: MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQLGITKEPSFISKRRVPYHDPQISKSLEWNGAISESNVVASPEPEAPETPKSQEAEQKDVTQERVHSLEASRVPKRTRSHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLSENVDNGLDRLLRKKAGLTVVPSYNALRNSEYQRQFVWKTSKETAPAFAANQVFHNKSQFVPPFKGNSVIHETEYKRNFKGLSPVKEPKLRNDLRENRNLETVSPERKSNKIDDRLKLEAEMELKDLHQPKRKLTPWKHQRLGKVNSEYRAKFLSPAQYLYKAGAWTHVKGNMPNQVKELREKAEFYRKRVQGTHFSRDHLNQILSDSNCCWDVSSTTSSEGTVSSNIRALDLAGDPTSHKTLQKCPSTEPEEKGNIVEEQPQKNTTEKLGVSAPTIPVRRRLAWDTENTSEDVQKQPGEKEEEDDNEEEGDRKTGKQAFMGEQEKLDVREKSKADKMKEGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKMKPPAPEQRKRMTSQDCLETSKNDFTKKESRAVSLLTSPAAGIKTVDPLPLREDSEDNIHKFAEATLPVSKIPKYPTNPPGQLPSPPHVPSYWHPSRRIQGSLRDPEFQHNVGKARMNNLQLPQHEAFNDEDEDRLSEISARSAASSLRAFQTLARAKKRKENFWGKT
What is the function of this protein?
Microtubule-binding protein that negatively regulates centriole duplication.  Binds to and stabilizes microtubules (PubMed:26337392).
What are the official names of this protein?
Nuclear protein MDM1.
What is the protein family that this protein belongs to?
Belongs to the MDM1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the centriole lumen.
Protein: NADE_LACLS
Sequence: MTLQEEIIKELGVKPIIDPKEEIRVSVDFLKDYLKKYPFIKSFVLGISGGQDSSLAGRLAQIAIEEMRQETADASYKFVAVRLPFGVQADEEDAQRALAFIKPDVSLAVNIKAAVEGQVAALNEAGVEVSDFNKGNIKARQRMITQYAVAGQYQGAVLGTDHAAENITGFFTKFGDGGADLLPLFRLNKRQGKALLAELGADPAIYEKVPTADLEEGKPGLADEIALGVTYNDIDDYTEGKVISEDAKAKIEAWWNKTQHKRHLPISIFDDFWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: CDCA7_BOVIN
Sequence: MDARRARQKDCRAKKNFKKFRYVKLISMETPSSSDDSCDSFASDNFANTRLQANREGCRTRSQCTRSGPLRVAMKFPPRSTRGAANKRTVPPEPPENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFPGRRSLPGPSSRPKTPRRRTFPGVACRRNPERRARPLTRSRSRVLGSLSALPTEEEEEEEEEEDKYMLVRKRKSMVGYMNEDDMPRSRRPGPMTLPHVVRPVDEITEEELENICNNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPECWGVRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQG
What is the function of this protein?
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells.  Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis.  May play a role as transcriptional regulator (By similarity).
What are the official names of this protein?
Cell division cycle-associated protein 7.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163 (By similarity).
Protein: PYRDB_THEAC
Sequence: MADLSTSVAGIRLENPLMLASGILDENGYTMLDVMNNGAAAVVTKSIGMEERNGYSAPVIVEYGDSLINAVGLSNPGIDNFAEEIRIAKRSGKPVIGSVFASDAESFVNLGRKMQEYGCDAVELNLSCPHVKGFGLEVGSDPDLVEDIVNEMKSKISVPVFAKLSPNVSDIIEIAKAAEKADAYVLINTVKAMKIDIRARMPVLTNAYGGLSGPAIKPVGVRYVYEVKKETGKDIIGVGGITTYEDAVEYIMAGASAVQIGTALYTVGKSVFRNIISQMNTFMDDEKFHSIQDMVGVAIR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_PSEP1
Sequence: MSLRKIIHVDCDCFYAAIEMRDDPRLAGRPMAVGGSPDHRGVIATCNYEARAYGVRSAMSSRHALKLCPDLLIVKPRFEAYREASREIHTIFRDYTELIEPLSLDEAYLDVSDSQWYSGSATRIAEDIRRRVARTLHITVSAGVAPNKFLAKIASDWRKPNGLFVITPNEVETFVAALPVARLHGVGKVTADKLTRLGIETCLHLREWSRLALVREFGSFGERLWGLARGIDERAVHNDSRRQSVSVENTYDTDLPDLASCLARLPDLLASLNERIARMDSSYLPDKPFVKVKFHDFSQTTMEQAGAGRDLESYRQLLGQAFARGGKPVRLLGVGVRLRDLRGAHEQLELFPPK
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_FERNB
Sequence: MRLVQTINEMKRLSKEAINKGKTIGFVPTMGYLHEGHLSLVKKAREDNDIVVVSIFVNPTQFGPNEDFNRYPRDLERDLRLLEPLNVDYVFYPSVEEMYPKNYSVYVDEVELSKYLCGAKRPGHFRGVCTVVTKLFNIVKPTRAYFGQKDAQQFRILRRMVQNLNMDVEMIEMPIVRESDGLAMSSRNVYLNEEERKEATRLHKSLLKAKELIESGERDVSKIKNSMLEILNHPLLKIDYVEIVDEETLKPIEKIEGKVIIALAVFVGKARLIDNMIINC
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_PELUB
Sequence: MADRIGKPVSQRQLRVGEMIRQSLGMIFARNEAKVPNLETNTITVTEVKMSQDLKIAKAYVLPLGGKDSELVIKKLKECSFLIRKALSKKIIMKYLPKILFAKDDSFEYAEKIENLIKQTNK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAPA_CANAL
Sequence: MNNQAYGVTPPISVANSTPKENELNDSLIKELKSRGSFESETATKKRVEVLNILQSMTEEFVYKVSIKKNISEGMARDVGGKIFTFGSYRLGVYGPGSDIDTLVVVPKHVSRNDFFEVFYELLKGRSELEEIAPVPDAFVPIIKIEFAGISIDLIFARLDIPRVPRDLTLDDKNLLKNIDEKDLRALNGTRVTDEILQLVPKPTVFKHALRCIKMWAQQRAVYGNIFGFPGGVAWAMLVARICQLYPNAVSAVIVEKFFHIYSQWAWPQPVLLKQIEDGPLQVRVWNPRLYALDRQHRMPVITPAYPSMCATHNITSSTQKVILSEFQRGIELMNDINVGKKSWSDLLERHDFFFRYKFYLCIVAATRSTYAEHLKYSGMVESKLRLLVQKLELVEGIELAHPYVKSFENGYYCDNAEEAHEIMNLYGTSKGDDRVKGVLHAENNDNNKENVENKVELHMTKLFIGLKLDLSKEGEKKLDIQYPCAEFFNICKGWQDFDSEKHFIQIKNVKLYDLSDDVYVDGETRPIKIAKRKRAVSKNEGKKKPKSVGTVSAA
What is the function of this protein?
Polymerase that creates the 3'-poly(A) tail of mRNA's.  May acquire specificity through interaction with a cleavage and polyadenylation factor (By similarity).
What are the official names of this protein?
Poly(A) polymerase PAPa, Polynucleotide adenylyltransferase a.
What is the protein family that this protein belongs to?
Belongs to the poly(A) polymerase family.
What are the subcellular locations of this protein?
Nucleus.