PharMolix/UniProtQA huggingface dataset:
Protein: HYAS3_HUMAN
Sequence: MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
What is the function of this protein?
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer.  Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation.  This is one of three isoenzymes responsible for cellular hyaluronan synthesis.
What are the official names of this protein?
Hyaluronan synthase 3, Hyaluronate synthase 3, Hyaluronic acid synthase 3, HA synthase 3.
What is the protein family that this protein belongs to?
Belongs to the NodC/HAS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Early endosome. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane (PubMed:26883802). Actives only when present in plasma membrane (By similarity). O-GlcNAcylation controls its membrane localization (PubMed:26883802). A rapid recycling of HAS3 between plasma membrane and endosomes is controlled by the cytosolic levels of UDP-GlcUA and UDP-GlcNAc (PubMed:26883802).
Protein: UIP4_YEAST
Sequence: MVTIVFDHPAEDFPELKIAGEFTNWEGVPMKINTSSGKWEYKFDESSVTKHNDKDKVHFKFIDQNGNWFADDEYPKEVDEHSNENNVATLNNEEDGGSAGEEKDEGDKTAHNTNENGSELYYEGPETPTPSLKGNVTFPSPKTAISQDGSAFAKETTRKERKYEHAPLNEVPVERDPKEENKELSPNFSQEQTENKQDKGLDNLSEGNDNDNTRVNEDTDVTDTQESEHEINGSDTENTDMSEQEEIQKIDKPADQNAKSIVKEGDANTEDYESVLKKLLGALGRFFGSWFSWLTTKMSSSEAS
What are the official names of this protein?
ULP1-interacting protein 4.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion outer membrane. Nucleus envelope.
Protein: SEC31_ASPCL
Sequence: MVRLREIPRTATFAWSPGAASPLIATGTRAGAVDVDFSNETCLELWDLGLSNDDASQELQPIAKIGTDSGFNDLAWTDSQDNSRGVIAGALENGSLDLWDADKLINGSSDAIISRMTKHSGAIKALQFNPKHSNLLATGGAKGELYISDLNNIANPYRLGSTAARADDIECLDWNKKVAHILVTGSSAGFVTVWDVKTKKESLTLNNMGRKAVSAVAWDPEKPTKLITSTPLESDPLIYVWDLRNSHAPERTLKGHESGVLSLSWCPQDPDLLLSSGKDNRTICWNPQSGQAYGEFPVVTNWTFQTRWNPHNPNFFATASFDGRISIQTIQNTRTDTAQAIADQNQSLDGEDFFAKAQTQPQVSNFSLPKAPKWLERPSSATFGFGGRVVSVGLIEKGKRASRIKITPFEVDEAVAKSTETFETALKEGDLRSICETRASQAASEEEKADWKVIEALISGNPRKGLIEYLGFQDQADEAADKLAKLGLDKEDVNGDTLTESRGSGAKKHKRLQSMFDANPEADSFLSDLAASKGAKTNNPFHIFTGSESEAEQGITRALLLGNFEKALDVALKEDRMSDAFVIAICGGQKCIEKAQEHYFSKQTGGPNYTRLLASIVGKNLWDVVYNADLSNWKEVMAALCTFADDKEFADLCEALGDRLGEQIRSTDDKALRKDASFCFLAGSKLEKVVAMWIEELRENEQKGIETAADDTSFSIHVRALQGLIEKVTIFRQATNFQDTERTKEADWKLAMLYDKYIEYADVVATHGRLQVAQKYLDLVPEKHPEAEIARNRIKLAMRQAAPQRTQSTVPAARTTLNRPLPQINAYPPQPTFSSPAPPAPQNPYAPPTAAPSQPANPYAPPAAAPSQPSNPYAPPTAAAAIPQPQVNNPYAPIGGGGYTPAGYQPPQAPAYGVQSLGGGSVPPPPRASNQSPAVTTYTTATNLPAWNDLPEGFTKPPTSRRGTPATAAAAISSPFPNQSPTFSQGPPPPGMPPTQRAPSVPPPPKGTVPPPRVTSPPTGFTPASNLSAPPPAANPYASLPQSPPIGSTMGIPAPASIPRGPSPYNAAPTMPPPSNRYAPSPAVQAASPQLATRAAVPPPPPAAASPYAPQPAAQPPVASSYAPSTPPPSQLPMQQGPPQGPPSRPGTASSQRKAAPAPPKYPPGDRSHIPADAMPIFEILSADMQRVKTRAPSSFKAQVDDAERRLNILFDHLNNEDLLRPNTIADMAELARAIQARDYETAKTIHIDIMTNRTDECGNWMVGVKRLISMSRATP
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein sec31.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC31 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YQGF_THET8
Sequence: MRVGALDVGEARIGLAVGEEGVPLASGRGYLVRKTLEEDVEALLDFVRREGLGKLVVGLPLRTDLKESAQAGKVLPLVEALRARGVEVELWDERFTTKLAQERLKHAPKRLRRDKGKLDELAAVVLLEDYLARGI
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOPRS_MOUSE
Sequence: MGSQPPPPGSPLSREEGEAPPLVPAEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFTNPEVRRFRYRTTMTRERSASLYSPSSTVSRRTTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQEQDIINFRRTLYRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSRSDSSVITISPDEAETQELDMNASTVRQAPWDDETPGPSYSSSEQVHVGVSSLLNSSDSSDEELVSGGTTSQIQGVQTNDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDSDTRISSKKEEKRSTSLPAPRDSSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQSRSGHDPRNHRKHGKKRLRNKRSRSRESSSRPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERRRSRSVSSNRSRTTSAGPDRVRNEKPGGKRKYKTRHLEGTSEEAQPAREFTSKGKDSHYQKSKLDGSYKNESDSFSDSRSSDRETKHKRRRRRTRSLSVEIVYEGKATDTSKHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGESEVKAGIECSNGSLPQPIQDGAFETKDVVTIEDELGVLDKDCDVTALADDLSTSQTVENCDSPAVPVEQTLDVREESTFASDLESQSSNVSIQAEPSRPVPSPRTSLSSVSPGRDCDVS
What is the function of this protein?
Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase.  Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation.  May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins.  May be involved in DNA-damage-induced cell death through IKBKE sumoylation.
What are the official names of this protein?
E3 ubiquitin-protein ligase Topors, RING-type E3 ubiquitin transferase Topors, SUMO1-protein E3 ligase Topors, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Tumor suppressor p53-binding protein 3, p53-binding protein 3, p53BP3.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
Protein: ATPE_CLOBL
Sequence: MKDNIELAIFTPEKNIKIGEIKEVITEGLDGDLAILPNHVNMITYLKPTITKYIDLNGNKNNIFTSSGVLKVEDNKVYIICDASEKPEDIDIKRAENAKKRAEERLRNKKEIDVKRAELALFRSIARIKIKEL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: BAED_BACVZ
Sequence: MNQPIVFMFSGQGSQYYQMGKELFAHNAAFRQKMLDLDDFAVSRFGYSVLKEMYHTGNRLSDPFDRLLFSHPAIFMAEYALAYALEQRGIRPDYVIGASLGEYAAAAVSGVLSAEDALDCVLEQARIVTETCRNGSMLAILGDPALYQDDPLLGEHSELASVNYHSHFVISGEREHIKKIMDDLREKQIPHQLLPVSYGFHSALVDQAEQPYKRFLAQKSIRTPFIPYISSATGEAETDIQADFFWDIVRKPIRFREALQFADSRQKGLYIDAGPSGTLAAFAKQILPAGSAERIRAIMTPFHKEQTHLQQIEDSILSPPGRRL
What is the function of this protein?
Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.
What are the official names of this protein?
Polyketide biosynthesis acyltransferase homolog BaeD, AT, Transacylase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBP4_AJECN
Sequence: MPRIGTTVKMIVAGVLLCIGGPALVQYVRPTEEELFQKFNPELQKRNLETRDQRQKDFDSFVTQLKTHAKSDKSIWHAIKESETTNRREVETRRKAELEEAERQKAQIRKELAEGS
What is the function of this protein?
Essential for the assembly of ubiquinol-cytochrome c reductase.  It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity).
What are the official names of this protein?
Assembly factor CBP4, Cytochrome b mRNA-processing protein 4.
What is the protein family that this protein belongs to?
Belongs to the CBP4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RS16_SHESR
Sequence: MVTIRLARGGAKKRPFYNIVVADSRNARDGRFIERVGFFNPLARGQEETLRLDLARVEHWVSNGAATTDRVAKLIKDAKAAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: EX7S_SHIDS
Sequence: MPKKNEAPASFEKALSELEQIVTRLESGDLPLEEALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEDASLTPFTPDNE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLAA_SHIFL
Sequence: MKLRLSALALGTTLLVGCASSGTDQQGRSDPLEGFNRTMYNFNFNVLDPYIVRPVAVAWRDYVPQPARNGLSNFTGNLEEPAVMVNYFLQGDPYQGMVHFTRFFLNTILGMGGFIDVAGMANPKLQRTEPHRFGSTLGHYGVGYGPYVQLPFYGSFTLRDDGGDMADALYPVLSWLTWPMSVGKWTLEGIETRAQLLDSDGLLRQSSDPYIMVREAYFQRHDFIANGGELKPQENPNAQAIQDDLKDIDSE
What is the function of this protein?
Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane (By similarity).  Required for intercellular spreading of S. flexneri (PubMed:8145644).
What are the official names of this protein?
Intermembrane phospholipid transport system lipoprotein MlaA.
What is the protein family that this protein belongs to?
Belongs to the MlaA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: H2A4_WHEAT
Sequence: MAGRGKAIGAGAAKKATSRSSKAGLQFPVGRIARFLKAGKYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRIVPRHIQLAVRNDEELTKLLGGATIASGGVMPNIHQHLLPKKASSSKVSTVDDDDN
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.4.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TREF_SHISS
Sequence: MLNQKIQNPNPDELMIEVDLCYELDPYELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSAKIFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRKFVENHFWLPEVYSSEYVSDPQNSLKEHIDQLWPVLTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLIPNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDTGRLASIRTTQFIPIDLNAFLFKLESAIANISALKGEKETEALFRQKASARRDAVNRYLWDDENGIYRDYDWRREQLALFSAAAIVPLYVGMANHEQADRLANAVRSRLLTPGGILASEYETGEQWDKPNGWAPLQWMAIQGFKMYGDDLLGDEIARSWLKTVNQFYLEQHKMIEKYHIADGVPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP
What is the function of this protein?
Hydrolyzes trehalose to glucose.  Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
What are the official names of this protein?
Cytoplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFI1_DROME
Sequence: MNHLSPPPSPHSQQPSPAGLGCHGAALDKQWMQRASAFNTVIASAAAQKLNGRDLPFLYNPLLYSSALLWPQFLLSSATALGTPLTPMTPKSPASVVLGQRDRDFALTPEKEHELQMNNNNENSKQDYQEQDEDMPLNLSTKERITSDDSNRDQYHSSSNNSSRSSSSSEVEQLHPMTSLNVTPPPLSAVNLKSSSTPQQQRQRSQGNIIWSPASMCERSARREQYGLKMEEQGDEEEHQVDPIVRKFKYERRTASISSLQSPISSLSAPASNAVQDLEFEVAQQQLYAHRSAFMAGLTGNNLELLTQHLKLKSEQPQQQQQQHRIKDEQQQDNRSAAALMNLVAAAEFGYMRNQHQQPQQQQQQQLHHQQQPQQHQHQQQHPDSTATDVARRSSSSSSYQGENEEKRSGRNFQCKQCGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCLKAFSQSSNLITHMRKHTGYKPFGCHLCDQSFQRKVDLRRHRESRHEEAPPVEDLKPLKMEVSSSSC
What is the function of this protein?
Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS).  Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation.  Correct expression requires expression of scalloped (sd).  Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.
What are the official names of this protein?
Zinc finger protein sens, Protein senseless.
What are the subcellular locations of this protein?
Nucleus.
Protein: YLAT1_MOUSE
Sequence: MVNSTKYEVAAQHEADDGSALGDGASPVAEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLMYSASFGLSLVIWAVGGIFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAITFANYMVQPLFPSCGAPYAAGRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIIAGIVRLGQGATANFENSFEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLSIGISMPIVTIIYLLTNVAYYSVLDIKEILASDAVAVTFADQIFGVFNWIIPVAVAFSCFGGLNASIVAASRLLFVGSREGHLPDAICMVHVERFTPVPSLLFNGVLSLVYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKDPDRPRPLKLSLFFPIIFCLCTIFLVAVPLYSDTINSLIGIGIALSGLPFYFFIIRVPEHKRPLFLRRIVASITRYLQILCMSVAAEMDLEDGELSKQDPKSK
What is the function of this protein?
Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux routeby exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:9878049).  Also mediates L-arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (By similarity).  The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity).  In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity).
What are the official names of this protein?
Y+L amino acid transporter 1, Solute carrier family 7 member 7, y(+)L-type amino acid transporter 1, Y+LAT1, y+LAT-1.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi- pass membrane protein.
Protein: POTEB_HUMAN
Sequence: MVAEVCSMPAASAVKKPFDLRSKMGKWCHHRFPCCRGSGTSNVGTSGDHDDSFMKTLRSKMGKWCCHCFPCCRGSGKSNVGTWGDYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQEVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRKSRKPENQQFPDTENEEYHSDEQNDTQKQLSEEQNTGISQDEILTNKQKQIEVAEKEMNSELSLSHKKEEDLLRENSMLREEIAKLRLELDETKHQNQLRENKILEEIESVKEKLLKTIQLNEEALTKTSI
What are the official names of this protein?
POTE ankyrin domain family member B, ANKRD26-like family B member 1, Prostate, ovary, testis-expressed protein on chromosome 15, POTE-15.
What is the protein family that this protein belongs to?
Belongs to the POTE family.
Protein: BTUC_YERPE
Sequence: MQTSQLFTALQQRQRQRDYRYLTGLVVMLLFALLISLCAGDVWIWPEHWFSESGKLFVWQLRLPRSMAVIMVGASLAVSGAVMQALFENPLAEPGLLGVANGAGVALVTAVLLGHGLLPIWVLSTCAIIGALLMTSILLSFTRRRLLTNAQLLLVGVALGIICSAMMTWAVYFSTSLDLRQLMYWMMGGFSGVDWRQQSLVLALLPTVIWLCCQGRVLNFMSLGEQQARQLGVSLHLWRNLLVLAIGLLVGISVALAGVISFIGLVIPHILRLTGLTDQRRLLAGCAFAGGGVLLLADVVARTVLSSAELPIGVVTATLGSPLFIWLLIRVKGVK
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Involved in the translocation of the substrate across the membrane.
What are the official names of this protein?
Vitamin B12 import system permease protein BtuC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLPP_FRATN
Sequence: MITNNLVPTVIEKTAGGERAFDIYSRLLKERIVFLNGEVNDHSANLVIAQLLFLESEDPDKDIYFYINSPGGMVTAGMGVYDTMQFIKPDVSTICIGLAASMGSLLLAGGAKGKRYSLPSSQIMIHQPLGGFRGQASDIEIHAKNILRIKDRLNKVLAHHTGQDLETIVKDTDRDNFMMADEAKAYGLIDHVIESREAIIK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFY_MOUSE
Sequence: MQPFSPIFFHLLFLLNGLSSRAAPSPGQPVVADLQGMLQPSGMPTGTLENLTRDQPTPGSSASHPPEHSETPPSASPHISTKILRETPSPSPFLSLETPIPDQLTSVAESQGTSQMSPSRATLGKPSETPKPDPTGISPSDSPETPKPNPSNTSPPESPESVYTDPTPTLHHESPEISKRDTPKLSPGEESKIPSPRPTQFLSSKSLETYDPSATRHLNSALEPTTHPDPTESPQSVFLTTHNSNPTVVPQTQFPTSPSQNVTETARTSDLEPSSSLPTQPTTFREEATTPSEPGLSPSPEAPAVTRVATPGLSTSDSPGTKELHVPQNSDPKGPDIPLPSARIAGPPAPLEHPNQVAPAPQRHSRGDTVNTIIVVERVKETGVTLVSRPRGSVGGALCLFFAGTGLLIGIFLLLWCLYRRASRHRSFAHHRLRDSGDEPVLHLDAPKDPLDLYFYAPDAWVPSHIATQPPPSTPPLPPKLPPPPRGPQRLEALSPAALSPNFF
What is the function of this protein?
Required for proper function of the olfactory system.  May be involved in establishing the acuity of olfactory sensory signaling.
What are the official names of this protein?
Golgi-associated olfactory signaling regulator, Golgi protein in olfactory neurons, Goofy.
Protein: LPXA_HAEIN
Sequence: MIHPSAKIHPTALIEEGAVIGEDVFIGPFCIIEGTVEIKARTVLKSHVVVRGDTVIGEDNEIYQFTSIGEVNQDLKYKGEATKTIIGNSNKIREHVTIHRGTIQGCGVTAIGNNNLLMINVHVAHDCQIKNNCILANNATLAGHVELDDFVIVGGMSAIHQFVIVGAHVMLGGGSMVSQDVPPYVMAQGNHARPFGVNLEGLKRRGFDKPTMHVIRNIYKMLYRSGKTLEEVLPEIEQIAETDSAISFFVEFFKRSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUB_CROS8
Sequence: MIKKISLLTALSVTAFSGWAQDSGSDSLVVTANRFQQPVNTVLAPTSVVTREDIERWQANTVIDVMRRLPGVDTAQSGGMGQLSSLFIRGTNSSHVLILVDGIRLNQAGVTGSSDLSQFPLALVQRIEYIRGPRSAVYGSDAIGGVVNIITTRAKDGTTLNAGIGSHSYQNYGGSTQQTLGDNTRVTLAGDYTYTRGFDVVAEGNNGGLAQPDRDGFMNKTLYGALEHAFSDQWTGFVRGYGYSNRTAYDGYYNSFTPDVLVDTRQLYSQTWDAGLRFNNDLFHSQLLSSYSHSKDYNYDPHLGRYDSTATLDEIKQYNVQWTNAVDVGHGNIGAGVDWQKQSTEPGTSYVTNGYDLRNTGVYLTALQKFGDVTLEGAVRSDDNSQFGRHGTWQSSAAWEFIEGYRFIASYGTAYKAPNLGQLYGFYGNDHLDPEESKQWEGAFEGLTAGVNWRVSAYRNDVDNLIDFNNNLQEYYNVGKARIKGVEATASFDTGPLTHTLGYDYVDARNAATNALLVRRAKQQVKYQLDTQLYDFDWSLTYHYLGTRYDTDFSTYPTQNVKLGGVSLWDVAVSYPVTSHLTVRGKIANLFDKDYETAYGYATAGREYTLSGSYTF
What is the function of this protein?
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space.  It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
What are the official names of this protein?
Vitamin B12 transporter BtuB, Cobalamin receptor, Outer membrane cobalamin translocator.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: OPPC_SALTY
Sequence: MMLSKKNSETLENFSEKLEVEGRSLWQDARRRFMHNRAAVASLIVLFLIALFVTVAPMLSQFTYFDTDWGMMSSAPDMASGHYFGTDSSGRDLLVRVAIGGRISLMVGIAAALVAVIVGTLYGSLSGYLGGKIDSVMMRLLEILNSFPFMFFVILLVTFFGQNILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIEAAQVGGVSTASIVIRHIVPNVLGVVVVYASLLVPSMILFESFLSFLGLGTQEPLSSWGALLSDGANSMEVSPWLLLFPAGFLVVTLFCFNFIGDGLRDALDPKDR
What is the function of this protein?
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Oligopeptide transport system permease protein OppC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PER_DROSA
Sequence: EGSGGSGSSGNFTTGSNIHMSSVTNTSNAGTGTSGTGNSGGGSGGGTGPGSGAIPPVTLTESLLNK
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
What are the official names of this protein?
Period circadian protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).
Protein: LACA_STAEQ
Sequence: MTIIIGSDVDGKRLKELIKDYLEDNDYDVLDVTEGKDLDFVDSTVSVAKEVQKSDDNLGIAIDAYGAGSFIVATKIKGMIAAEVSDERSAYMTRSHNNARMITMGAEIVGDTLAKNVAKEFVNGHYDGGRHQIRVDMLNKMC
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.