PharMolix/UniProtQA huggingface dataset:
Protein: MASZ_RHILW
Sequence: MSRIDKNGLAIEAVLHDFLVQEVLPGLAIDADKFFADFSAIVHDLAPKNRALLARRDELEVKIDDWYRQHGAPADMDDYQSFLRGIGYLLPEGSDFQVSTQNVDPEIASIAGPQLVVPVMNARYALNAANARWGSLYDALYGTDAIPETDGAEKGRGYNPKRGEKVIAWVRDFLDMSVPLQDSSWKNVGNFTVKDGILVIRSVDGEQAMLVDGGHFAGYRGDAAAPTHILLKNNGIHIKIVIDATTAIGKTDPAHISDVWLESAITTIMDCEDSIAAVDAEDKTVVYRNWLGLMKGDLQEEVVKGGTSFVRKLNPDLDYTGPDGTVFELHRRSLMLVRNVGHLMTNPAILDRDGAEVPEGILDAVITGLIALYDIGPAGRRKNSRTGSMYVVKPKMHGPEEVAFAVEIFSRVEDALGMARNTIKMGIMDEERRTTVNLKECIRAARERVVFINTGFLDRTGDEIHTSMEAGPMIRKGDMRQAAWISAYENWNVDIGLECGLAGHAQIGKGMWAMPDLMAAMLEQKIAHPKAGANTAWVPSPTAATLHATHYHRVNVARVQQGLKDRARAKLSDILSVPVAVRPNWTPEEIQRELDNNAQGILGYVVRWVDQGVGCSKVPDINNVGLMEDRATLRISAQHMANWLHHQVVTEAQIVETMKRMAAVVDRQNEADPLYQPMAGNFDGSIAFQAALDLVLKGREQPNGYTEPVLHRRRLELKAKQAG
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFG_SHEPW
Sequence: MKKSMLKNGLLLGLFALLCTGLVAIVNQLTYAKIKQQEQIELSRVLHQIIPDEIHDNELTEHCITIQDSDFLGTTQPLPAYIATRNGDGVAIAIETVAPDGYNGNIKIIIGLNKAGEVLGVRTLSHQETPGLGDKIELRKSDWVTKFNGLTVSSEKDKRWHVKKDGGQIDQFTGATITPRAYVNAVKLATLYFNEHKQKLLSAPASCEVDNE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit G, Rnf electron transport complex subunit G.
What is the protein family that this protein belongs to?
Belongs to the RnfG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AROC_PSET1
Sequence: MAGNSIGQLFKVSTFGESHGVALGGVVDGTPAGLEITEADLQIDLDRRKPGQSRYTTQRREDDQIKILSGVFEGKTTGTSIGLLIENTDQRSKDYGKIKDVFRPGHGDYTYWHKYGLRDYRGGGRSSARETAIRVAAGSIAKKYLKQFHGIEIKACLSQLGPIKADVFDWNEVENNLFFFPDVSKLEALDEYMRGLKKQGDSVGAKVKVVASNVPVGLGEPVFDRLDAELAHSLMSINAVKGVEIGDGFDVIEQKGSEHRDELTPNGFTSNHAGGVLAGISTGQDIIASIALKPTSSITIPGNSINTENEAVEMITKGRHDPCVGIRAVPIAEAMMAITLMDHLLRQRGQNPHVHHEHGPIPGSV
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: MURB_MYCTA
Sequence: MKRSGVGSLFAGAHIAEAVPLAPLTTLRVGPIARRVITCTSAEQVVAALRHLDSAAKTGADRPLVFAGGSNLVIAENLTDLTVVRLANSGITIDGNLVRAEAGAVFDDVVVRAIEQGLGGLECLSGIPGSAGATPVQNVGAYGAEVSDTITRVRLLDRCTGEVRWVSARDLRFGYRTSVLKHADGLAVPTVVLEVEFALDPSGRSAPLRYGELIAALNATSGERADPQAVREAVLALRARKGMVLDPTDHDTWSVGSFFTNPVVTQDVYERLAGDAATRKDGPVPHYPAPDGVKLAAGWLVERAGFGKGYPDAGAAPCRLSTKHALALTNRGGATAEDVVTLARAVRDGVHDVFGITLKPEPVLIGCML
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDX5_PANTR
Sequence: MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVENCIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQASFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ
What is the function of this protein?
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner.  Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10.  The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.  Involved in transcriptional regulation; the function is independent of the RNA helicase activity.  Transcriptional coactivator for androgen receptor AR but probably not ESR1.  Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation.  Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis.  Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation.  Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1.  As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity).
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX5, DEAD box protein 5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=During the G0 phase, predominantly located in the nucleus. Cytoplasmic levels increase during the G1/S phase. During the M phase, located at the vicinity of the condensed chromosomes. At G1, localizes in the cytoplasm.
Protein: NUOB_ACIAC
Sequence: MIEGVMKEGFITTSYDSVVNWAKTGSLWPMTFGLACCAVEMMHAAAARYDIGRFGAEVFRASPRQSDLMIVAGTLCNKMAPALRKVYDQMSEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALIYGIIQLQQKIRRTHTIARV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FACE1_MOUSE
Sequence: MGMWASVDAMWDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTRVPAELEQIMDSDTFEKSRLYQLDKSTFSFWSGLYSEVEGTFILLFGGIPYLWRLSGQFCSSAGFGPEYEIIQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTLEFFMKDAIKKFIVTQCILLPVSALLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVPNKDNQEESGMEARNEGEGDSEEVKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRRELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSTWHYSHPPLLERLQALKNAKQD
What is the function of this protein?
Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:11923874, PubMed:12235369, PubMed:17652517, PubMed:27462105).  Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:11399759, PubMed:17652517).  Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses (PubMed:28246125).  Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:28246125).
What are the official names of this protein?
CAAX prenyl protease 1 homolog, Farnesylated proteins-converting enzyme 1, FACE-1, Prenyl protein-specific endoprotease 1, Zinc metalloproteinase Ste24 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein.
Protein: RAC9_ARATH
Sequence: MSASMAATSTSSATATTFIKCVTVGDGAVGKTCLLISYTSNTFPTDYVPTVFDNFNANVLVDGKTVNLGLWDTAGQEDYNRVRPLSYRGADVFILAFSLISRPSFENIAKKWVPELRHYAPTVPIVLVGTKSDLRDNMQFPKNYPGACTIFPEQGQELRKEIGALAYIECSSKAQMNVKAVFDEAIKVVLHPPSKTKKRKRKIGLCHVL
What is the function of this protein?
Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation.
What are the official names of this protein?
Rac-like GTP-binding protein ARAC9, GTPase protein ROP8.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Associated with the membrane when activated.
Protein: KTHY_NITEC
Sequence: MQRGKFITFEGIDGAGKSTHLAWLASFLRDKGLEVIVTREPGSTALGEQLRQLLLDHRQAMHAETETLLMFAARREHLDKVILPALERGAWVISDRFTDASFAYQGGGRGVPSARLEILEQWVQKGFSPDLTVYFDVPVTISRQRVQSARTADRFELEPDLFFERVRQAYLQRAKQFSERIRVVDGSLSLEEVRTAMVEVVEKFWSAQASSGYRM
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: IBPB_SALSV
Sequence: MRNYDLSPLLRQWIGFDKLANALQNSGESQSFPPYNIEKSDDNHYRITLALAGFRQEDLDIQLEGTRLTVKGTPEQPENEPKWLHQGLVMQPFSLSFTLAENMEVSGATFTNGLLHIDLTRNEPETIAPQRIAINERSALNS
What is the function of this protein?
Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpB, 16 kDa heat shock protein B.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_CAERE
Sequence: MNRFFKIVLTSTRRASTNGSGKRKTPFEGDKVHIPDEPYNSKVRFFICFKKKLKHGIQIDESLLSEMPPIDAKLISHLERLSLVRFDSEQAVANLRNSIRMAKRLELVDVEDVEPMHTVWESQECPTFDDVEEEPLPIDKVFRNAAVRFDDFFVTPPGNVPLESNERFDLNVINKWDTIGKPVAPEAKTIRLAEGRRK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial, Glu-AdT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: USPB_ECO55
Sequence: MISTVALFWALCVVCIVNMARYFSSLRALLVVLRNCDPLLYQYVDGGGFFTSHGQPNKQVRLVWYIYAQRYRDHHDDEFIRRCERVRRQFILTSALCGLVVVSLIALMIWH
What are the official names of this protein?
Universal stress protein B.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y269_CALS4
Sequence: MRKDLLILTDILKANVAPALGCTEPGAVAYAVSKAREILGEEPREVYVAVDRDILKNGMFVSIPGTKEKGLVFAAALALVCGKSEYKLEALREATEEDIKKAHKIVNRKAVKIVLEKDAEGLYIKASVVGDKHRATVIVKDAHDNIVYEERDGVVLKAKEENLKEDKSWLKAKIKEFTIEDFLDYCDSVDFKEIEFIGEGIEMNKKIAYAGLNEEVGVGIGKMLKRQIRDEESLAKALTAAASEARMSGYPLPVMSSAGSGNHGLVAILPIAIIGEERGYDREKIIRAITLSHLLTAYVKAYIGVLSPICGCGVAAGVGMSAGLTYLLGGSRKQIKGAVSNMLAGLSGMICDGAKIGCAYKLSISVTAALEASKFAMENIFIPSDNGILGNTAEESIKNLGRISVEGMKNADDVILDIMLKKQ
What are the official names of this protein?
UPF0597 protein TTE0269.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: NU5M_LUMTE
Sequence: MLRMFNTSLVASKLMWVIFTGMLAPTLYMVHCNSTLLLEWNLFSISSTPMMMTIILDPLGLMFSCTVVMISANILKFSTIYMKEDKFINRFTVLVLLFVLSMNMLIFFPHLIILLLGWDGLGIVSFILVIYYQNPKSLAAGMITALTNRIGDVMLLLAIAWTLNQGHWNILHMWAVDENMYQALVIIIAAMTKSAQMPFSSWLPAAMAAPTPVSALVHSSTLVTAGVFLLIRFYNFLSSVWWFTTFLLFVAVSTTLMAGLSASSECDMKKIIALSTLSQLGMMMAAMGLGMAHMAFFHMVTHAMFKALLFVCAGSFIHSHMHSQDLRWMGNLTKQMPTTTSCLIMANLALCGFPFMSGFYSKDMIVEASLYYPHNSLMINLILFAVGLTAFYSTRFTMCVVLSPNNCGPYMHLEESNSLTSPMLLLASMSVISGSALTWILPLKQEMMMIPLDQKLKTLMLVTLGALMSWFFLTTTNMTKTCLYIRHPIINYFSCTMWFLVPLSSQFMMKLPMYVSHNYLKLTDQSWLELLGGQGINNVSSKASNIYLASLKSTPMNYLMMSSMLLLVATLVAI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PLPP1_HUMAN
Sequence: MFDKTRLPYVALDVLCVLLAGLPFAILTSRHTPFQRGVFCNDESIKYPYKEDTIPYALLGGIIIPFSIIVIILGETLSVYCNLLHSNSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP
What is the function of this protein?
Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599).  Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309).  Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599).  It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599).  Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590).  May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity).
What are the official names of this protein?
Phospholipid phosphatase 1, Lipid phosphate phosphohydrolase 1, PAP2-alpha, Phosphatidate phosphohydrolase type 2a, Phosphatidic acid phosphatase 2a, PAP-2a, PAP2a.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein.
Protein: SAUSS_SANAS
Sequence: MENQKVPISSVPNLKELSRPIANFPPSIWGDRFINYTCEDENEQAQKERQVEELKEQVRRELAATVDKPLQQLNIIDATQRLGIAYHFENEIEESLEHIYLHTYVKNNCFQGSHDLYSVALWFRLLRQDGYKVSCDVFDNFRDYEGNFKNSLMEDAKGLLELYEATHLSVHGEEMLDDALEFAKTRLESIVNHLNYPLAEQVRHALYRPLRKGLPRLEAVYFFRIYEAYHSHNKALLKLAKLDFNLLQSLHRKELGDMARWWRSLDFATKFPFARDRLVEGYFWILGVYFEPQYSLAREITTKVFAMISTIDDIYDAYGTLDELKLFTEAIQRWDVGSLDQLPEYMKPCYKSILDVYNEIEEEMANQGSLFRMHYAKEVMKTIVEGYMDEAKWCHEKYVPTFQEYMSLALVTSGYTFLTTISYLGMGGIASKEAFEWLFSHPPIIEASESICRLMDDMSSHKFEQERGHVASGIECYMKQYGVIEEEAHDEFHKRLVKAWKDINEGFLRPYAVPEPLLMRILNLTRVMDVIYKNEDSYTHVKKAMKDNIASLLIDPMIV
What is the function of this protein?
Catalyzes alpha-humulene and delta-cadinene, as well as beta-elemene, the thermal rearrangement product of germacrene A and several other bicyclic sesquiterpenes when incubated with (2E,6E)-farnesyl diphosphate.
What are the official names of this protein?
Sesquiterpene synthase, SauSesquiTPS.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
Protein: FBX38_HUMAN
Sequence: MGPRKKSVKTCIMNNEIPEEMTADETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDASFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDDNNAQNNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDIVQEDGEVVAESGNNTPAHSQAIIPVDVDEEQAGPSGLQRVVKPTSITVHDSESDDEEDSLELQEVWIPKNGTRRYSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHNTASQSPDFVRTVNSGGSSEPSPTEVDVSRQCACSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVLLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606).  Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606).  May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity).
What are the official names of this protein?
F-box only protein 38.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Accumulates predominantly in the cytosol. Exported from the nucleus in a XPO1/CRM1-dependent manner.
Protein: YBBO_ECOL6
Sequence: MTHKATEILTGKVMQKSVLITGCSSGIGLESALELKRQGFHVLAGCRKPDDVERMNSMGFTGVLIDLDSPESVDRAADEVIALTDNCLYGIFNNAGFGMYGPLSTISRAQMEQQFSANFFGAHQLTMRLLPAMLPHGEGRIVMTSSVMGLISTPGRGAYAASKYALEAWSDALRMELRHSGIKVSLIEPGPIRTRFTDNVNQTQSDKPVENPGIAARFTLGPEAVVDKVRHAFISEKPKMRYPVTLVTWAVMVLKRLLPGRVMDKILQG
What are the official names of this protein?
Uncharacterized oxidoreductase YbbO.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: SYY_STRPC
Sequence: MNIFEELKARGLVFQTTDEQALVKALTEGQVSYYTGYDPTADSLHLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKETVLEWSDKIKGQLSTFLDFENGDNKAELVNNYDWFSQISFIDFLRDVGKYFTVNYMMSKDSVKKRIETGISYTEFAYQIMQGYDFYELNDKHNVTLQIGGSDQWGNMTAGTELLRKKADKTGHVMTVPLITDSTGKKFGKSEGNAVWLDADKTSPYEMYQFWLNVMDDDAVRFLKIFTFLSLDEIAEIETQFNAARHERLAQKTLAREVVTLVHGEEAYKQALNITEQLFAGNIKNLSANELKQGLSNVPNYHVQSEDSLNLVDMLVTAGISPSKRQAREDVQNGAIYINGDRVQDLDYQLSNDDKIDDQLTVIRRGKKKYAVLTY
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SO1A1_MOUSE
Sequence: MEETEKKVATQEGRFFSKMKVFLMSLTCAYLAKSLSGVYMNSMLTQIERQFGIPTSVVGFITGSFEIGNLLLIVFVSYFGRKLHRPIIIGVGCVVMGLGCFLMASPHFLMGRYKYETTISPTSNLSSNSFLCIENRTQTLKPTQDPTECVKEIKSLMWIYVLIGNTMRGIGETPIMPLGISYIEDFAKSENSPLYIGILEMGKIVGPIIGLLLGSFFARVYVDIGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKKELQDNVDVTKYEKVEKHRERAKKENLGITKDFLPFMKSLCCNPIYMLFSLTSVLQINGFASTFTFLPKYLEQQYGKSTSEAVFLIGVYSLPPVCLGYLISGFIMKKFKITVKKAAYIAFGLSLSEYFIFLCNYLLTCDNFPVAGLTTSYKGVQHPLYGEKNVLADCNTRCSCLTDTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIGSSGNSSAVLGLCKKGPECDNKLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAGIPAPVYFGALIDRTCLHWGTLKCGQPGACRMYDINRFRHIYLGLPAAVRGSSFLPAVFILILMRKFHFPGDIHSPDTELAEMKLTEKESECTDVCRSPKVENDGELKTKL
What is the function of this protein?
Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:10600646, PubMed:11267661).  Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (PubMed:10600646).  Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity).  Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (By similarity).
What are the official names of this protein?
Solute carrier organic anion transporter family member 1A1, Sodium-independent organic anion-transporting polypeptide 1, OATP-1, Solute carrier family 21 member 1.
What is the protein family that this protein belongs to?
Belongs to the organo anion transporter (TC 2.A.60) family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi- pass membrane protein.
Protein: CITD_SHIB3
Sequence: MKINQPAVAGTLESGDVMIRIAPLDTQDIDLQINSSVEKQFGDAIRTTILDVLAHYNVRGVQLNVDDKGTLDCILRARLEALLARASGIPTLPWEDCQ
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.