PharMolix/UniProtQA huggingface dataset:
Protein: PSBE_GLOC7
Sequence: MSGTTGERPFSDIVTSIRYWVIHSITIPMLFVAGWLFVSTGLAYDVFGTPRPDEYYTQERLELPILKDRYNTDQQIQEFNK
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: FPG_THET8
Sequence: MPELPEVETTRRRLRPLVLGQTLRQVVHRDPARYRNTALAEGRRILEVDRRGKFLLFALEGGVELVAHLGMTGGFRLEPTPHTRAALVLEGRTLYFHDPRRFGRLFGVRRGDYREIPLLLRLGPEPLSEAFAFPGFFRGLKESARPLKALLLDQRLAAGVGNIYADEALFRARLSPFRPARSLTEEEARRLYRALREVLAEAVELGGSTLSDQSYRQPDGLPGGFQTRHAVYGREGLPCPACGRPVERRVVAGRGTHFCPTCQGEGP
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: FUSA3_GIBZE
Sequence: MFATQSPRHLQVLLCRTKKFALASPPICYKVGAASSGSIRKFLSARFSTSARARNLKQSVLDNSGRHGVYLYPTLKPEPLNVVSAKDTTVVFSNGKTIEDTTCGAAVACLGYNNERVKNAMIKQMDSFCYSNSLFYGHEIGEELAAELIGGTNGEMAKVYLMCSGAEAMESAMKMARQYYMELNPRQPQRTNFIAREGSYHGSTLGALSMGGHVGRRKLFEGMLLDNNIHRVSAANEYRGKADGQTTEEYVQQLADELDRKFQEVGPETVAAFVAETLVGATLGTIPAPTGYFKAMKKVCDKYGALLILDEVMCGMGRCGSLHEWEQEGVVPDIQTVAKGLAGGFAPMAAMFINHRLSDALMSGSGVFSHGHTYQGHPVGCAAALEVQRIIREDNLVENVRKNGEYLGKLLHDQLDDHPNVGNIRGRGFFWSMEFVADKETKEPFLPSDGIAKKVHLTALNDVGISLYPGMGTKDGVAGDHAWIGPAYNCSKQDIERIVSKVKEAVVLALG
What is the function of this protein?
Aminotransferase; part of the gene cluster that mediates the biosynthesis of the lipopeptide fusaristatin A (PubMed:25412204).  Fusaristatin A consists of a polyketide chain linked to three amino acid residues glutamine (Gln), dehydroalanine (dehydro-Ala), and beta-aminoisobutyric acid (PubMed:25412204).  The biosynthesis starts with formation of a linear polyketide chain by the highly reducing polyketide synthase PKS6 (PubMed:25412204).  The gene cluster does not contain an acyl-CoA ligase or an acyl-transferase, and it is therefore predicted that the polyketide is transferred directly to the nonribosomal peptide synthetase NRPS7 (Probable).  Modules 1-3 from NRPS7 incorporate dehydro-Ala, Gln, and beta-aminoisobutyric acid in the compound, which is released by cyclization (PubMed:25412204).  The beta-aminoisobutyric acid units are most likely not freely available to the NRPS, but can be synthesized from thymine, which requires a dehydrogenase, a monooxygenase, and an aminotransferase.  The fusaristatin A cluster contains a cytochrome P450 monooxygenase (FGSG_08207) and an aminotransferase (FGSG_17085), which theoretically can perform two of the enzymatic steps (Probable).  The enzymes may however also be involved in biosynthesis of dehydroalanine or modification of the polyketide (Probable).  The dehydro-Ala residue can be a result of cyclization, where serine is dehydrated (Probable).  The last gene of the cluster encodes a protein with an A/B barrel domain found in variable enzymes, which hampers functional prediction (Probable).
What are the official names of this protein?
Aminotransferase FGSG_17085, Fusaristatin A biosynthesis cluster protein FGSG_17085.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: HRCA_MYCPA
Sequence: MGSADERRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLDDVKPLSAAERRAIQNFLESGVDLDDVLRRAVRLLAQLTRQVAIVQYPTLSSSTVRHLEVIALTPARLLMVVITDSGRVDQRIVELGDVIDDHELSRLREMLGQALVGKKLSAASVAVADLAEQLRSPDGLGDAVGRSATVLLESLVEHSEERLLMGGTANLTRNAADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETAAEQMVGTSMVTTAYGTSDTVYGGMGVLGPTRMDYPGTIASVAAVAMYIGEVLGAR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: WASH3_HUMAN
Sequence: MTPVRMQHSLAGQTYAVPLIQPDLRREEAVQQMADALQYLQKVSGDIFSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQEKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLGKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPGITNDLMYIADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPSVQGAPREVVDPSGGRATLLESIRQAGGIGKAKLRSMKERKLEKKQQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGEGPGGAFARVSDSIPPLPPPQQPQAEEDEDDWES
What is the function of this protein?
Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130).  Involved in endocytic trafficking of EGF (PubMed:20175130).  Involved in transferrin receptor recycling.  Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity).  In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function.  In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation.  Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity).  Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity).  Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).
What are the official names of this protein?
Putative WAS protein family homolog 3, Protein FAM39DP.
What is the protein family that this protein belongs to?
Belongs to the WASH1 family.
What are the subcellular locations of this protein?
Early endosome. Early endosome membrane. Recycling endosome membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasmic vesicle, autophagosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. Localizes to MMP14-positive late endosomes and transiently to invadipodia (By similarity). Localized to Salmonella typhimurium entry sites (By similarity).
Protein: CSTR4_ORYSI
Sequence: MQRNGVMECSVCHSKVVAPSPRSVSRAYDKHRSKISSKYRALNFLLVSGDCILVGLQPILVFMSKVDGKFQFSPISVNFLTEVTKVIFAIVMLIIQSRKQKVGEKPLLSLSTFVQAARNNALLAVPALLYAINNYLKFIMQLYFSPATVKMLSNLKVLVIAILLKFIMRRKFSIIQWEALALLLIGISVNQLSSIPDGTKSFGLAVTTIAYIYTLIFVTVPSLASVYNEYALKSQFDTSIYLQNLFLYGYGAIFNFLGILGTVIFQGPESFDILQGHSRATMFLICNNAAQGILSSFFFKYADTILKKYSSTVATIFTGLASAAFLGHTLTVNFLLGISIVFISMHQFFSPLAKVKDDKPAGALEPEDAQNHRSSDSSFVNMTAGAADDASHLTSTDERKPLLPI
What is the function of this protein?
Sugar transporter involved in the transport of CMP-sialic acid from the cytoplasm into the Golgi.  May transport important nucleotide sugars such as CMP-Kdo (2-keto-3-deoxy-D-manno-octulosonic acid) in physiological conditions.
What are the official names of this protein?
CMP-sialic acid transporter 4, CMP-SA-Tr 4, CMP-Sia-Tr 4, CMP-sialic acid transporter-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. CMP-Sialate:CMP antiporter (TC 2.A.7.12) subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: MRAY_STRPI
Sequence: MFISISAGIVTFLLTLVGIPAFIQFYRKAQITGQQMHEDVKQHQAKAGTPTMGGLIFLIAAVVVSFLVALFSKQLTNNVGMILFILVLYGLVGFLDDFLKVFRKINEGLNPKQKLALQLLGGVIFYLFYERGGDMLSIFGYQVHLGIFYIVFALFWLVGFSNAVNLTDGIDGLASISVVISLSAYGVIAYVQGQMDILLVILAMIGGLLGFFVFNHKPAKVFMGDVGSLALGGMLAAISMALHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKRIFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLTLAILYLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYA_SALRD
Sequence: MSHDPMNPHLQSSADPSRSSEEIRQDFLQFFQAKGHEVVPSASLVPDGDGTLLFTNAGMNQFKDVFLGTGQRPYSRAVDTQKCLRVSGKHNDLEEVGHDTYHHTFFEMLGNWSFGDYFKAEAIRWAWELLVERWGLAPDRLYATVHEGDDDFGLSADAEAYDLWLSETPLPEERVLYEPSKENFWMMGDTGPCGPCSELHVDLRPPEARQETPGRELVNVDHPQVMELWNLVFIQYNAQTDGSLEPLDDQHVDTGMGFERMVAVLQGKESTYDTDLFAPLLQAMADRSPREEIRGYDDLHIEDDDEHEQVRIALRVVADHIRAIAFAISDGVMPSNEGRGYVIRRILRRAVRYGYQTLELEEPFLHRLVDPLIEKMGGPFDGLAEQQEFIEQAIRSEEESFLETLGTGIEFFERVVPHVTGFQDTDGEESDRLLGALREDAQAMDLLEKAYVDTDDENDILHSFARTARGGTLPGQIAFLLHDTYGFPIDLTRLMARERDLDVDMEGYETLMDRQQERARAASDFAVDQSDVQAWQSVSPGEASVFVGYDRAVVPDAEVRAVRVVETGDTQQYEVELSRTPFYAEAGGQVGDTGTLRFGDESVQVLDTQREGERIAHTVDTLPEPLDGPVEAAVDAERRNHIRAHHTATHLMHAVLRETLGDHVQQKGSLVAPDRLRFDFSHFDAVDEDTLRHIERRVNTAIQQNIPKQEARDVPIDEALDRGATALFDEQYGDRVRVITFDPDFSMELCGGTHVDATGEIGLFRFLSEGSVASGVRRVEAVAGKAALEHVESELETLTRARRQFRSLHTSLPEAIAEVQEERDRLAGEVDQLRRGQLSDQLDTFIAENAASVDGITVVTGRLDRASMDDLQELGQQFRDKLGEGAVGVLGSVGEDGEKAYVVATVADDLVDDGALRAGDLVGTLGDRLGGGGGGRPSLASAGGRDPEALDTVLDGVPALVRDRLE
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_NITWN
Sequence: MSGSKSSSETEEGLAFQPSFDASGLVTCVATDAKTGDVLMVAHMNEEALRRTVETGDAWYYSRSRKALWRKGESSGQVQRVLEMRTDCDQDAVWIKVEQQGAACHTGRRSCFYRAVAKGEGAGIRLAFVDAERLFDPAEVYRAKA
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NS1_I50A0
Sequence: MDPNTVSSFQVDCFLWHVRKQVADQELGDAPFLDRLRRDQKSLRGRGSTLGLNIETATRVGKQIVERILKEESDEALKMTMASAPASRYLTDMTIEEMSRDWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTNEDVKNAIGVLIGGLEWSDNTVRVSKTLQRFAWRSSSENGRPPLTPKQKRKMARTIRSEVRRNKMAD
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: SPR2B_MOUSE
Sequence: MSYYQQQCKQPCQPPPVCPPPKCPEPCPPPKCPEPCPPPVCCEPCPPPKCPEPCPPPVCCEPCPPPVCCEPCPPQPWQPKCPPVQFPPCQQKCPPKNK
What is the function of this protein?
Cross-linked envelope protein of keratinocytes.  It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase.  All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
What are the official names of this protein?
Small proline-rich protein 2B.
What is the protein family that this protein belongs to?
Belongs to the cornifin (SPRR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_SHIF8
Sequence: MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEDGSPLMVYSRQQQQALAQRLPDTPVALGMSYGSPSLESSVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMVPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_HAMD5
Sequence: MSNNMIRLATRQSPLALWQAHYVKTGLEFFHPDLKVILLPMVTQGDNILGTALSKTGGKGLFVKELERAVLDNRADIAVHSIKDMPLYFPEGLGLVAVCEREDPRDAFLSLRYHDVAQLPEGSVVGTSSLRRQCQLYKNYPGIVVRDLRGNVGARLKKLDQGDYDAIVLAVAGLKRLGLENRMTQILRPETSLPAAGQGAIGIECRLDDTVTLQRVATLNHRPSQLKISCERALLKRLEGGCQTPIGSYAEIENDELWLRAFVGAPDGQLIIDGERRGNFDSAEKIGFELANELLSRGAEAILAQLNRQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: NADM_METM7
Sequence: MRAFLIGRWQPFHKGHLEIIKKISKEVDEIIIGIGSCQKSHTLTDPFTAGERMMMITKTLENYDINYYAIPINDIDYNAVWVSSVESLTPPFTTVYTGNSLVRELFSEKNYTVKKPELYNRTDYSGTKIRKKMLEGSDWEHLVPKEVVKVIEEIDGINRIRRLSEKDYDEE
What are the official names of this protein?
Nicotinamide-nucleotide adenylyltransferase, NAD(+) diphosphorylase, NAD(+) pyrophosphorylase, NMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PUDPU
Sequence: MTYIRKTHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYASDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTFLETWNIGVILLFTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAMIHLLFLHDTGSNNPTGIPSDADKIPFHPYYTIKDIMGVLLLIFFLMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLILMPLLHTSKQRSMMFRPFSQCLFWALVADLLTLTWIGGQPVEYPFVVIGQLASILYFLIILVLMPIISTIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LACY_CITFR
Sequence: MYYLKNTNFWMFGFFFFFYFFIMGAYFPFFPIWLHEVNHISKGDTGIIFACISLFSLLFQPIFGLLSDKLGLRKHLLWVITGMLVMFAPFFIYVFGPLLQVNILLGSIVGGIYLGFIYNAGAPAIEAYIEKASRRSNFEFGRARMFGCVGWALCASIAGIMFTINNQFVFWLGSGCAVILALLLLFSKTDVPSSAKVADAVGANNSAFSLKLALELFKQPKLWLISLYVVGVSCTYDVFDQQFANFFTSFFATGEQGTRVFGYVTTMGELLNASIMFFAPLIVNRIGGKNALLLAGTIMSVRIIGSHSHTALEVVILKTLHMFEIPFLIVGCFKYITSQFEVRFSATIYLVCFCFFKQLAMIFMSVLAGKMYESIGFQGAYLVLGIIRVSFTLISVFTLSGPGPFSLLRRRESVAL
What is the function of this protein?
Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Lactose permease, Lactose-proton symport.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Oligosaccharide:H(+) symporter (OHS) (TC 2.A.1.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLUC2_XENLA
Sequence: MKSTCYMIGILLLILQNTYQSPVPEADGSSRSVKAARNEAVDDSEQLKEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRSGGLSRRNADYERHAEGTFTSDVTQHLDEKAAKEFIDWLINGGPTKEIISRRNAEIERHAEGTYTNDVTEYLEEKATKAFIEWLIKGKPKKIRYSRHAEGTFTNDMTNYLEEKAAKEFVGWLINGRPKRKDLLEEH
What is the function of this protein?
Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
What are the official names of this protein?
Glucagon-2, Glucagon II.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: TA2R4_GORGO
Sequence: MLRLFYFSAVIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNMERSVYLSAFFVLCFMFLDSSSLWFVTLLNILYCVKITNFQHSVFLLLKRSISPKIPRLLLAFVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQMEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).  In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 4, T2R4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.
Protein: SYH_SODGM
Sequence: MAKNIQAIRGMNDYLPEETAFWQCVEGTLKNVLASYGYSEIRLPIVEQTPLFQRAIGEVTDVVEKEMYTFADRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYVGPMFRYERPQKGRYRQFHQMGAEVFGQQGPDVDAELILLTARWWRALGIQEHVALELNSIGSLEACARYREALVAFLRQHEDRLDEDCRRRMHTNPMRVLDTKNPDIQVLLNDAPVLTDYLDDDSQAHFSGLCELLDLAGIPYTVNPRLVRGLDYYNRTVFEWVTTRLGSQGTVCGGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPDFAAAARVDAYLVAAGDGVQREALRLAEQLRDELSSLRLMTNYGGGSFKKQFGRADKHGARIALVLGESEAAAGQVVVKDLATGNQETLAQSDVAARLASILG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGDQ_ECO57
Sequence: MLFAWITDPNAWLALGTLTLLEIVLGIDNIIFLSLVVAKLPTAQRAHARRLGLAGAMVMRLALLASIAWVTRLTNPLFTIFSQEISARDLILLLGGLFLIWKASKEIHESIEGEEEGLKTRVSSFLGAIVQIMLLDIIFSLDSVITAVGLSDHLFIMMAAVVIAVGVMMFAARSIGDFVERHPSVKMLALSFLILVGFTLILESFDIHVPKGYIYFAMFFSIAVESLNLIRNKKNPL
What are the official names of this protein?
UPF0053 inner membrane protein YgdQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0053 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NHR77_CAEEL
Sequence: MPIVELADPICPVCEFPSNVELHFGGLVCGACAAFFRRTVSLNIRYLCEKNNQCKGMRKNCRACRFDYCVKIAGMKRNLVKQRRNSTNTPMYILNRRKDSGNEEVVRGMLKRMYLQFSSFSGFVTTTQSKWAHHSRKSSMSPNKEAEKDVSKILKISHGSLLKYYIYQITHDKRNNMNTLNIKSVEEFLEITSVQNKLAAELCKTCPGVDLLDNEDILILRKYFQFSNVWIESTWNYLRENNSVPIDDSELDLKLLKFINQVKSTLLVSFSQLKFNTIEFAAFKSICIWKLVYHETSRAMKIIAQEHYESVMKALNDYYQTYTSMDSMQIATRIGEITLLIISVFQMYHDMAKLYIQLGLPF
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-77.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SELO_CLOB1
Sequence: MKERKVIIKTGLNLENSYTSLPEIFFTRQSPSRVPSPKLAVLNYSLITSLGLNAQVLQSADGVEILAGNKTPEEAIPISQAYAGHQFGHFTMLGDGRAILLGEHITPQGERFDIQLKGSGKTPYSRGGDGKAALGPMLREYIISEAMNALGIPTTRSLAVVTTGESIMRETELSGAILTRVAASHIRVGTFEYVSRWGTVEELRALANYTLQRHFKKGYDKENPYLFLLQEVIEKQAELIAKWQLVGFVHGVMNTDNMTISGETIDYGPCAFMDVYDPETVFSSIDIYGRYAYGNQPNIATWNLARFAETLLPLLHINPNEAIKIAENAVSDFTKLYKNNWLSGMRAKLGIFNEELEDEYLIEDLLSIMHKYGADYTNTFRALTFDNIEDTVLGGKVEFDKWYKLWQERLTRQEEAKLSSKQLMKSSNPSVIPRNHRVEEALEAAVKEGDYSVMEKLLDALSKPYDHSKEQDYYSKLPEPSTCPYQTYCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: MCE1_YARLI
Sequence: MSGIVPEIPGEQAPPDAAHQLKVDVARLLQKPKLNFPGAQPVSFARKHIEEELFKRDYYVCEKSDGLRCLMYVTWENNPDTGPQQVTYLITRNNEFFFIPMVHFPSNDGKPLQDTIVDGELVLTKAEPRSLHFLMFDCLACNKILLTGRPLDKRLGYLNAAISHPLKEYLHKNPEVARDFPFSVRVKDMQFAYNVMNVFASFPHLPHITDGLIFTCRDHPYVSGTDERILKWKKQDENSVDFLMTMKFPIFEDTNGESWTDYDAKPEITLLVWTGRDGSRPYGELYLTDEEWDNLKALEEPLEERVVECIKDDKKRWRYLRFRDDKTNANYITTVEKVIDSIDDPVSEKNLLDAAPKIKELWKERNRRPRDEDRKRVGGDDHDHGAKRARQ
What is the function of this protein?
Second step of mRNA capping.  Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.
What are the official names of this protein?
mRNA-capping enzyme subunit alpha, GTP--RNA guanylyltransferase, GTase, mRNA guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic GTase family.
What are the subcellular locations of this protein?
Nucleus.