PharMolix/UniProtQA huggingface dataset:
Protein: RS8_NEIMF
Sequence: MSMHDPISDMLTRIRNAQRANKAAVAMPSSKLKCAIAKVLKEEGYIEDFAVSSDVKSILEIQLKYYAGRPVIEQIKRVSRPGLRIYKASSEIPSVMNGLGIAIVSTSKGVMTDRKARSQGVGGELLCIVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PEPE_MYCTU
Sequence: MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRAETFERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRVCDWVDGDDPYGLVSAVLGGAPVATAVTDSMPALHMLPLADALGVLPVLATDVLRRLRMVKEETEIDALRKAGAAIDRVHARVPEFLVPGRTEADVAADIAEAIVAEGHSEVAFVIVGSGPHGADPHHGYSDRELREGDIVVVDIGGTYGPGYHSDSTRTYSIGEPDSDVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLAEAGLAEYFVHRTGHGIGLCVHEEPYIVAGNDLVLVPGMAFSIEPGIYFPGRWGARIEDIVIVTEDGAVSVNNCPHELIVVPVS
What are the official names of this protein?
Probable dipeptidase PepE.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GPDA_RAT
Sequence: MAGKKVCIVGSGNWGSAIAKIVGSNASQLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAATGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGIDEGPNGLKLISEVIGESLGIPMSVLMGANIASEVAEEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGSVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKFPLFTAVYKVCYEGQPVGEFICCLQNHPEHM
What is the function of this protein?
Has glycerol-3-phosphate dehydrogenase activity.
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic, GPD-C, GPDH-C.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_ALIF1
Sequence: MTLHTDTIVAQATAPGRGGVGIIRVSGPKAKDVALAVIGKELKPRYAEYAPFKDENGLELDQGIALYFPNPHSFTGEDVLELQGHGGPVVMDMLIKRILKIDGIRTARPGEFSERAFLNDKMDLAQAEAIADLIDASSEEAAKSALNSLQGVFSNKINTLVESLIYLRIYVEAAIDFPEEEIDFLADGKVSGDLQGIIDNLNAVRKEANQGAIMREGMKVVIAGRPNAGKSSLLNALSGKDTAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWDEIAQADRVLFMVDGTTTDATDPKLIWPEFLDRLPKNMGMTVIRNKADQTGEDLGICHVNDPTLIRLSAKTGEGVDALRNHLKECMGFSGNQEGGFMARRRHLEALEKAAQHLDIGQQQLEGYMAGEILAEELRIAQQHLSEITGEFTSDDLLGRIFTSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_ECOL6
Sequence: MQKFDTRTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRALGPEPMAAAYVQPSRRPTDGRYGENPNRLQHYYQFQVVIKPSPDNIQELYLGSLKELGMDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEYADVDFLFTCFEQYEKEAQQLLALENPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCNKDK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL2_HPV70
Sequence: MVSSRASRRKRASATDIYKTCKQSGTCPPDVVNKVEGTTLADRFLQWASLGIFLGGLGIGTGTGTGGRTGYIPLGGRPSTVVDVTPARPPVVIEPVGPTEPSIVQLVEESSVVSSGTPIPTFTGTSGFEITSSATTTPAVLDITPASGSVQISTTSYTNPAFADPSLIEVPQTGEVSGNIFVTTPTSGTHGYEEIPMQVFASHGTGTEPISSTPVPGVSRVAGPRLYSRAYHQVRVNNFDFVTRPSSFVTFDNPAFEPGDTSLTFEPADTAPDPDFLDIVRLHRPALTSRRGTVRFSRLGKKATMFTRRGTQIGAQVHYYHDISNITATEDIEMQPLLTSESTDGLYDIYADADIDNAMLHTTSHTGSTGPRSHLSFPSIPSTVSTKYSNTTIPFTTSWDIPVTTGPDIVLPTASPNLPFVPPTSIDTTVAIAIQGSNYYLLPLLYYFLKKRKRIPYFFTDGFVAV
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: URE2_BURM1
Sequence: MIPGEILTDDGEHELNAGRATITLVVANTGDRPVQVGSHYHFYEVNDALAFDREAARGFRLNIAAGTAVRFEPGQTRTVELVALAGDRVVYGFQGKVMGPL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MISCB_BACSU
Sequence: MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYLIEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQVDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIRSTPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAKLMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity).  Also involved in protein secretion processes.  It has an overlapping, although partly distinct, function compared to SpoIIIJ(MisCB).
What are the official names of this protein?
Membrane protein insertase MisCB, Foldase YidC 1, Membrane integrase YidC 1, Membrane protein YidC 1.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Found uniformly distributed in both the mother cell and forespore following sporulation.
Protein: KEFC_SALDC
Sequence: MDSHTLLQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFVIGLELDPQRLWKLRASVFGGGALQMVVCGGLIGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLTVSQVGRSAFAVLLFQDIAAIPLVAMIPLLAASGASTTLGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLVENPLRILLLLAGFLAIKIVMLWLVARPLGVPAKQRRWFAVLLGQGSEFAFVVFGAAQMADVLEPEWAKALTLAVALSMAATPIFLVLLTRMEKTATGEAREADEIDEEQPRVIVAGFGRFGQIAGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLSELVKSHFPHLQIIARARDVDHYIRLRQAGVAMPERETFEGALKSGRQALEALGLGRYEARERADLFRHFNTRMVEEMAKGENDPLSRAAAYKRTSAMLSEIITEDREHLSLIQRHGWQGTAEGKHSGEAADEPEVKPSI
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefC, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL24_NOSS1
Sequence: MKKDTTPKFHKLHVKTGDTVQIIAGKDKGKVGEVIKALPQLSKVVVKGVNIKTKQIIAGKDKGKVGEVIKALPQLSKVVVKGVNIKTKHVKPQQEGESGRIVTQEAPIHSSNVMLYSTKQNVASRVCYTFTAEGKKVRKLKKTGEILDN
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: LEUC_SYNP6
Sequence: MSRGTLFDKVWDLHTVATLPSGQTQLFIGLHLIHEVTSPQAFSMLRDRGLTVKFPGRTVATVDHIVPTENQARPFADSLAEEMIVTLERNCRENGIRFYNIGSGSQGIVHVIAPEQGLTQPGMTIACGDSHTSTHGAFGAIAFGIGTSQVRDVLASQTLALSKLKVRKIEVNGELQPGVYAKDVILHIIRKLGVKGGVGYAYEFAGSTFAAMSMEERMTVCNMAIEGGARCGYVNPDQITYDYLQGREFAPQGEAWDRAIAWWESLRSEADAEYDDVVVFDAAEIAPTVTWGITPGQGIGITETIPTPDSLLDEDRAVAAEAYSYMDLEPGAPLQGTKVDVCFIGSCTNGRLSDLREAAKVAQGRKVAAGIKAFVVPGSERVKQQAEAEGLDQIFTAAGFEWRQAGCSMCLAMNPDKLEGRQISASSSNRNFKGRQGSASGRTLLMSPAMVAAAAIAGEVTDVRNWLN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: HTPX_BAUCH
Sequence: MMRIVIFLLTNLAVMVVFGILLTCVGTHSSNTVRLMIISGLFGFCGAFISLLMSKFIALRSVGGKVISQPQNETEHWLLNIILNQAQKIGITMPQVAIYNAPDMNAFATGPSRNNSLVAVSTGLLQNMPRTEIEAVIAHEISHISNGDMVTITLISGIVNTFVIFISRFLAQLTAGFIGSNNEESNNGNKLVYMIVSTILELAFGILASIIVLWFSRYREFYADAGSANIVGCDKMIAALQRLKTSYEPKVTNNIKIFCINGYQKSLSEFFMSHPPLNKRIEALRYGTYMK
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUQ1_APLCA
Sequence: MTSSIYGFITLSVVALISQTTCRSLDLLLDGDFNNGLASFDGSSKWSRLPLEFLAAFDLDPHQAQGQHLAEAPEAPLMEAMKRSRGPSPRRLRSYLRRAAGLRGMKRKMFWQPLGYMPASARAHNNVPEVVNENSQDSGTNVFRYG
What is the function of this protein?
May have important functions in renal physiology and in animal behavior, as does bradykinin.
What are the official names of this protein?
Bradykinin-like neuropeptide.
What are the subcellular locations of this protein?
Secreted.
Protein: MIC60_YEAS7
Sequence: MLRTTASRKIVLRRGLASINTGTTVASKKASHKFRNTFWTIALSATAFYAGGIIYSQKNDKFGDFFSNNVPFAEDLLETYEHYHDRPTLFLEDSWDGLKAKSNDLLSGLTGSSQTRRSNRENIEVKKILSLEPLNIETENSDPQLKEIIGSLNDLINSLNDSNLSIPESEFNSIKKSNQNMLTNLSQLNETLKEALSNYMIQRTSEVITELNTQYENSKREFEKNLQKNLLQEVDEFKENLTKQKDKELEEKLKANEELLQAKHANEVGLLSITQVKEFNKIIKDKIEKERNGRLAHLEEINSEVNDLSKSIDRSSKILSKNEALVQLTFQVDEIKSRINNNNLPDVNIDKELSRLKLLSNLLSTFNKKSCCDDGDCCSCKKGNKNEGKEGKISCKCKPKTNPPSLLSVALDELESTCSGKKILSNEQIYNRWNLLADDFKTASLLPPNSGILGQLTAKVFSLFLFTKTGNPSNATDFDSVYARVGDNLRVSNLNDAVEEVVSLKGWPHKVCESWIEDARRKLEVQRLVEILDCEIRTL
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Plays a role in keeping cristae membranes connected to the inner boundary membrane.  Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
What are the official names of this protein?
MICOS complex subunit MIC60, Mitofilin.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic60 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RS3_CERS4
Sequence: MGQKVNPIGMRLQVNRTWDSRWFAESKDYGNLLLEDLKMREFIHDYAKQAGVSKVIIERPHRKCRVTIHTARPGVIIGKKGADIETLRKKLSAFTKSELHLNIVEIRKPELDAQLVAESIAQQMERRVSFRRAMKRGVQNAMRIGALGIRVNVSGRLGGAEIARTEWYREGRVPLHTLRADIDYATSEATTPYGIIGVKVWIFKGEILEHDPQAHDRRHSEAQEGAAPRPPRRDRERA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PRP16_YEAST
Sequence: MGHSGREERIKDIFKELTSKELTPGLLLTLQKLAQKPNTNLEQFIASCKALTKLSSNNPIIFNELLELLKNKSEEDSTGPKKIAPSINKRKKFKIQLDLDDNEDELDSPVQKKPAPTRTLFKRIDKLKAKQLRQYSPTVKDPSPNSEQQTQNGHAETKDYEPTRSEVVEEDREWYDNDDDYGNLVPEPLSELPEEAKLLPVIRNIDNDDALRNTVQLYPIPLKQRMEWIPPFLSKFALENKVPTSIIIGSISETSSQVSALSMVNPFRNPDSEFSANAKRGSKLVALRRINMEHIQQSRDNTTVLNTAMGEVLGLENNNKAKDKSNQKICDDTALFTPSKDDIKHTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAISVAKRVAMEMQVPLGKEVGYSIRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMNAKKFSAFFGNAPQFTIPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIHLANDCSSGDILIFMTGQEDIETTFDTLQEKFLQVYSKKFGTANFEEINDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDELSKFPFIDKPPLQTFLSSLYELWFIGAIDTSGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQVFYRPKERQKEADIARNKFFIAKSDHLTLLNVFEQWRANNFSSHWCNKHFVQYKSLVRARDIRDQLLTILKSQKIPVISSGKDWDIIKKCICSGFAHQAAKITGLRNYVHLKTGVSVQLHPTSALHGLGDLPPYVVYHELLMTSKEYICCVTSVDPFWLMEYGGLLYDIKRIKNDQEATTTGLFGEHYEHTLDKVEDDIDINIRRCKDMRDSVIQELKMTDNSNKEDKKQKTKKQNILNGKENSMKPFKRRKPFF
What is the function of this protein?
Influences the fidelity of branchpoint recognition in yeast splicing.  This is RNA-dependent ATPase which is essential for viability.  It may mediate one of the many ATP-requiring steps of spliceosome assembly and that accuracy of branchpoint recognition may be coupled to ATP binding and/or hydrolysis.
What are the official names of this protein?
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Binds to the spliceosome.
Protein: PNCB_SALEP
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADAIREQVDAMQHLRLQEDEFQWLSGLPFFKPDYLNWLREFRYNPAQVCVTNDNGKLNIRLTGPWREVIMWEVPLLAVISELVHHYRSPNAGVDQALDALESKLVDFTALTANLDMSRFHLMDFGTRRRFSREVQQAIVKRLQQESWFVGTSNYDLARRLALTPMGTQAHEWFQAHQQISPDLATSQRAALAAWLNEYPDQLGIALTDCITMDAFLRDFGIEFASRYQGLRHDSGDPVAWGEKAIAHYEKLGIDPLTKTLVFSDNLDLPKAVELYRHFASRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPQVRKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: ATPB_HELPG
Sequence: MKAMEGKIIQVLGPVVDVEFESYLPAIFEALDINFEVNGVQKSLVLEVAAHLGGNRVRAIAMDMTEGLVRNQAVKARGKMIEVPVGEEVLGRIFNVVGESIDNLEPLKPSLTWPIHRKAPSFEQQSTKTEMFETGIKVIDLLAPYSKGGKVGLFGGAGVGKTVIIMELIHNVAYKHNGYSVFAGVGERTREGNDLYFEMKEGGVLDKVALCYGQMNEPPGARNRIAFTGLTMAEYFRDEKGLDVLMFIDNIFRYAQSGAEMSALLGRIPSAVGYQPTLAGEMGKLQERIASTKNGSITSVQAVYVPADDLTDPAPASVFAHLDATTVLNRKIAEKGIYPAVDPLDSTSRILSPQMIGEKHYEIATGIQQVLQKYKDLQDIIAILGLDELSEEDKKTVERARKIEKFLSQPFFVAEVFTGSPGKYVTLQETLEGFGGILEGKYDHIPENAFYMVGSIQEVLEKAKNMKNS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PTMG_PENSI
Sequence: MLFLAPGYIFPHVATPVTVAIDFAQAVKEGAYSFLDLKASPVPNPELFQPPSRVSIGMTGGREERNEEIIRGPLNYLLSLPGKDIRGKLIDALNEWFRVPEDKLSTIKEIIVILHTASLLIDDIQDSSQLRRGNPVAHRIFGVAQTINSANYAYFLAQAKLADLNDSRAFDIFTKGLLKLHRGQGMELYWRDNLICPTEEEYVEMVSCKTGGLFYLAVQLMQLNSEVTVNFSSFINLLGIIFQIRDDYMNLQSGTMTKTKGFSEDLTEGKFGYPIIHSIHAAPNDQQLIQILKLKTNDEVIKQYAVRYIESTGSFIYCREKLDLYLQEANETFQGLELLLGPSKGIRAILNFLRTR
What is the function of this protein?
Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
Geranylgeranyl pyrophosphate synthase penG, GGPP synthase, GGPPSase, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase, Penitrem biosynthesis cluster 1 protein G.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: DCTA1_POLNA
Sequence: MTTSAPTEKLPLYRSLYFQVVCAVIAGVALGYFYPSVGESMKPLGDGFIKLIKMMIAPIIFCTVVVGIAGMEDMKKVGKTGGLALLYFEVVSTFALIIGLLLVNLFQPGAGMNIDAATLDTKSIAAYTGPGKMVSTTDFILNVIPTAFVDAFAKGEILQVLLLAILFGFALHRFGGRGTLVFDMIEKSSHVLFTIVGFIMKVAPIGAFGAMAFTIGKYGVGSLFSLGKLMGAFYLTCLIFIFGVLGAIARIHGFSVWKFIKYIKEELLIVLGTSSSESVLPRMMEKMENLGAKKTTVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPMTLMQEITLLGVLLLTSKGAAGVTGSGFIVLAATLSAVGTVPVAGLALILGIDRFMSEARALTNLIGNGVATLVVAKWTNELDMERLQAGLNNETWEEAQEPERVLDKKTEHMPVSAMSDAG
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein 1.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METN_STRA5
Sequence: MSKEPIIKLDNIDVTFHQKKREINAVKDVTIHINQGDIYGIVGYSGAGKSTLVRVINLLQEPSAGKITIDDQVIYDNKVTLTSTQLREQRREIGMIFQHFNLMSQLTAEQNVAFALKHSGLSKEAKAAKVAKLLELVGLSDRAQNYPSQLSGGQKQRVAIARALANDPKILISDESTSALDPKTTKQILALLQDLNKKLGLTIVLITHEMQIVKDIANRVAVMQNGKLIEEGSVLDIFSHPRESLTQDFIKIATGIDEAMLKIEQQEVVKNLPVGSKLVQLKYAGHSTDEPLLNQIYKEFEVTANILYGNIEILDGIPVGEMVVILSGDEEKLRQACQAITDSQVQLTLLKEGGKA
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RF1_FRAP2
Sequence: MKDSIKAKLQSLIERHEEVSALLGEANVISDQNKFRDLSKEYSHLEPIVMAFKEYTQALEDKEAAYEMLNEKDAELVEMAKEELKSANESIERLEDELQILLLPRDPNDDANIFLEIRAGTGGDEASIFSGDLFKMYSKYAEQRGWKIEVVSASEGEHGGYKEIISRIYGDGVYSQLKFESGAHRVQRVPATESQGRIHTSACTVAVMPEADEVEGIDINPADIKVDTFRASGAGGQHVNKTDSAIRITHIPTGVVVECQDQRSQHKNRAAAMSMLKSKLLQAEIDKQQKEQSDTRKNLVGSGDRSERIRTYNYPQGRVTDHRINLTLYKLDEVMEGSLDSIIQPLILEHQADLLATMSDE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THG1_ARATH
Sequence: MINSVGVVRKEAENCNCLQVFFVSGSFKVDSVEAKKKEENFRETLRDMANSKYEYVKSFELEDEVMLPNLMVVRIDGRDFSRFSQVHEFEKPNDETALNLMNSCSAAVLEEFPDIIFAYGYSDEYSFVFKKTSRFYQRRASKILSLVASFFAAVYVTKWKEFFPQRKLLYAPSFSSKVVSCASAEVLQAYLAWRQQDCHANNQYDTCFWMLVKSGKSVSETQEILKDTQKQQKNELLFQKFGINYKTLPELFRQGSCLFKKKVEETVKHDENGNPVKRLRRKAVFVHSENIAGRSFWNEQPSLYNDLGHFTKDIGKIEPDFIRSFQFENKLLPLTWVVVRIDGCHFHRFSDVHEFEKPNDEQALKLMNSCAVAVLEEFEDIHFAYGVSDEYSFVLKKESELYKRQSSKIISAVASFFTSTYVLQWGEFFPHKELKYPPSFDGRAVCYPTYNILLDYLAWRQVDCHINNQYNTCFWMLVKSGKNKTQSQDYLKGTQTREKNELLSRQFGIEYNSLPVIFRMGSSVFRLKEAENGVVSGKKLEGEVVVDHCNIIERCFWEEHLHILSYS
What is the function of this protein?
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
What are the official names of this protein?
tRNA(His) guanylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the tRNA(His) guanylyltransferase family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: PRO_BLVJ
Sequence: MGNSPSYNPPAGISPSDWLNLLQSAQRLNPRPSPSDFTDLKNYIHWFHKTQKKPWTFTSGGPTSCPPGRFGRVPLVLATLNEVLSNEGGAPGASAPEEQPPPYDPPAILPIISEGNRNRHRAWALRELQDIKKEIENKAPGSQVWIQTLRLAILQADPTPADLEQLCQYIASPVDQTAHMTSLTAAIAAAEAANTLQGFNPKTGTLTQQSAQPNAGDLRSQYQNLWLQAGKNLPTRPSAPWSTIVQGPAESSVEFVNRLQISLADNLPDGVPKEPIIDSLSYANANRECQQILQGRGPVAAVGQKLQACAQWAPKNKQPALLVHTPGPKMPGPRQPAPKRPPPGPCYRCLKEGHWARDCPTKATGPPPGPCPICKDPSHWKRDCPTLKSKNKLIEGGLSAPQTITPITDSLSEAELECLLSIPLARSRPSVAVYLSGPWLQPSQNQALMLVDTGAENTVLPQNWLVRDYPRIPAAVLGAGGVSRNRYNWLQGPLTLALKPEGPFITIPKILVDTSDKWQILGRDVPSRLQASISIPEEVRPPVVGVLDTPPSHIGLEHLPPPPEVPQFPLN
What is the function of this protein?
The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane.  Cleavages take place as an ordered, step-wise cascade to yield mature proteins.  This process is called maturation.  Displays maximal activity during the budding process just prior to particle release from the cell.
What are the official names of this protein?
Gag-Pro polyprotein.
What are the subcellular locations of this protein?
[Matrix protein p15]: Virion. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p12-pro]: Virion.