PharMolix/UniProtQA huggingface dataset:
Protein: MUTL_HALH5
Sequence: MAKIIKLDDHLSNKIAAGEVVERPASVVKELVENALDANSRKITIEVEAGGLDRIRVIDDGDGIEREDVETAFFRHATSKIKTDKDLFQIATLGFRGEALPSIASVSHVQIKTSTGGDGGTEMVLEGGVIKKIGSTAMGKGTDLTVTQLFYNTPARLKYVKTVHTELGNISDVVNRLALAHPYVSFQLFHNGKNVLRTSGNGDQLQVIAAIYGRTVAKQMVPLSGETIDFTVSGFAAKPEVTRASRQYMSLLVNGRYIRNVALSKAIQQGFHTLLPIGRYPIAIVNIELDPQLIDVNVHPSKLEVRVSKEEELCRLVTETIERAFKKEQLIPEATKPTGGKQKSEQLSFTLDDFTSAKPSEDRGSTSSNEENEQRSSIDKNVLFQEERKLSNDLPSINMVREASASVEPALEKEPPAAELTAGAKGAMEQASMEEETSNSLPANRVPTMYPIGQMHGTYILAQNDQGLYIIDQHAAQERMKYEYFREKVGEVTNELQELIVPITVECTLQEAAYIEEHLEDLKQVGLFFEEFGPQTFMIRQHPTWFPKGLEEETIREMIDQLMEKRKVDIKKLREEVAILMSCKAAIKANRHLRHDEMYALLEALRKSSDPFTCPHGRPIIVQITTYEMEKMFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RNH_MAGSA
Sequence: MSETAPKPETVEIYTDGACSGNPGPGGWGAILRFKGIEKELKGGESPTTNNRMEMMAVLVALNTLTRSCAVDVYTDSEYVKKGMTEWLRGWKARGWKTADKKPVKNDDLWKALDEAAARHKVSWHWVKGHAGHPENERADALAREGIADLRART
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHYH_PENRW
Sequence: MRLQAVTAVAAWAVASACQSLPGTRTIWSRDADYKELSEKLSPSAKAYYPGSDEFEKANTRWSNLEVPTVNIVIVPGNENDVVETVKFANKKGLPFLAWNSAHGAMTTLGQMDSGIEIYLDQLSGVEIAEDGKTVTIAGGTKSKLVTDTLWAAGKQTVTGACECVGYIGPALGGGHGWLQGRHGTIGDQFESANIVLANGTLTSIDSSSDLWWAIKGAGHNFGIVTSVTSKTYDIEHKDWAIEILTFSGSKVVELYEAVNTHLLKNGTQPTDLINWSYWVNVPSADANNPVIQILIIQEGVNTVDSAYTTPFHSLSPITKEAHSGSYTDLAKWVGITTTDEPCQKTGAMNPRFPIYLETYNPQAQKKAFELFSDAIRGDSIFNGSLFAFDGYSTQGVRAIDEKSTAFAFRNQNVLTAPLISYMPDGPELDEKVAKLGNQLRQILHEGTGREHIPAYVNYANGDEGPEQWYGSESWRQSKLQSLKKKYDPNGMFSFYGPIA
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:29196288).  the NRPS chyA mediates the condensation of anthranilic acid and alanine into the intermediate 2-(2-aminopropanamido)benzoic acid (PubMed:29196288).  The remainder of the pathway is highly branched yielding at least 13 chrysogine-related compounds (PubMed:29196288).  The malonyl transferase chyE converts 2-(2-aminopropanamido)benzoic acid and 2-(2-aminopropanamido)benzamidine into 2-(2-(2-carboxyacetamido)propanamido)benzoic acid and 3-((1-((2-carbamoylphenyl)amino)-1-oxopropan-2-yl)amino)-3-oxopropanoic acid, respectively (PubMed:29196288).  ChyD is an amidase, being responsible for the amidation of the carboxylic acid moiety of 2-(2-aminopropanamido)benzoic acid, 2-(2-(2-carboxyacetamido)propanamido)benzoic acid and 2-(2-((4-amino-1-carboxy-4-oxobutyl)amino)propanamido)benzoic acid (PubMed:29196288).  ChyC is involved in the same reactions as ChyD, but plays a more minor role in the amidation reactions compared to chyD (PubMed:29196288).  The oxidoreductases chyH and chyM are involved in oxidation reactions that form N-pyruvoylanthranilamide from 2-(2-aminopropanamido)benzamidine and (1-((2-carbamoylphenyl)amino)-1-oxopropan-2-yl)glutamine, respectively (PubMed:29196288).  N-pyruvoylanthranilamide is further converted via two further branches in the pathway, yielding chrysogine and additional chrysogine-related coumpounds (PubMed:29196288).  Chrysogine is likely formed by a spontaneous ring closure from N-pyruvoylanthranilamide (PubMed:29196288).
What are the official names of this protein?
FAD-linked oxidoreductase chyH, Chrysogine biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: CCR5_GORGO
Sequence: MDYQVSSPTYDIDYYTSEPCQKTNVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
What is the function of this protein?
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.  May play a role in the control of granulocytic lineage proliferation or differentiation.  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
What are the official names of this protein?
C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPA_HAEIN
Sequence: MQLNSTEISELIKKRIAQFDVVSEARNTGTIVSVSDGIIRIHGLSDVMQGEMIALPGNRYAMALNLERDSVGAVVMGPYADLAEGMEVQCTGRILEVPVGRGLLGRVVNTLGQPIDGKGEIENDGFSPVEVIAPGVIDRRSVDQPVQTGYKAVDSMVPIGRGQRELIIGDRQTGKTALAIDAIINQRNSGIKCIYVAIGQKASTIANVVRKLEEHGALANTIVVAASASESAALQYLAPYAGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVNEDYVEKFTKGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNPGISVSRVGGSAQTKVIKKLAGGIRTALAQYRELAAFAQFASDLDDATRKQLSHGEKVTELLKQKQFTPLSVAEQAVILFAVEFGYLDDVELSKIASFETALLDYSNRNHAEFMQELNKTGNYNDEIKDTLKSILDGFKANSAW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NTPP_RUEST
Sequence: MSTHILLASGSEIRAKLLRQAGVDFRVEVARVDEDAIKTALEADGASPRDIADTLAEAKARKVSGKFPEEMVLGCDQVLDFEGTLLSKPKDKNQALQQLKAMRGKRHMLLSAAVIYCDAKPLWRHVGQVRLVMRMASDAYLESYVERNWESIRHAVGAYKLEEEGVRLFTTIDGSYFNVLGLPMLELMNYLGLQGIIEQ
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOT_AEDAE
Sequence: MMSKARISSLMKVISSGSCSCPAHSRSSTGGLNVSSENEYAFEMSSSTIRYGPGVSKELGHDLQNLNAKNVCIVTDRNVAKLNSVKVAFDSLTRCGIQYQVYDETRVEPTDQSLLHAAEYARQNKFDSFVAIGGGSVIDTCKVANLFSADREAEFLDYVNAPIGKAKEVNVKLKPLIAVPTTAGTGSETTGVVIFDYKPLHAKTGISSKYLRPQLGLIDPLHTLSQPEKVAAYCGFDVFCHALESFTAIPYTERGSAPMNPNLRPPYQGSNPISDVWARFALKIIRENFISAVFNQDDLKARSNMHLASTMAGVGFGNAGVHLCHGLSYPISGHVKKFVPDGYSGDHPIIPHGLSVVMTAPAVFKFTAASCPERHLEAAELLGANVSKANRNDAGSILSDVVRQYMYKLKIENGLDSLGFTRDDIQSLVKGTLPQERITKLAPRAQTEEDLASLFENSMTVY
What is the function of this protein?
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG).  L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).
What are the official names of this protein?
Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial, HOT.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SKPO1_CAEEL
Sequence: MKSLLFSILLIYLIQLVRSEECTDKHIHCFFWSQEGECEVNPRWMKKHCQKACGTCSLTSPTPLTRQQDVPTARTFDDQQDRQFLPSRPSSIPEGCNSVMTVEAETRRIFSSGQLTARFRQQMCAEEQVAPDCSINQCFHKKYRSMDGTCNNLQNPVKGAAFTAFTRLMPAAYDDGFNTLVSASRRNRPNPREVSVFLLSSERSLPGHVNSLLMLFGQFVSHDITSNAAQNFCGCQNSGPMCASIFAPPSDRSRRCIPFTRSFPICGTGQFGRVREQLNMNTAAIDASLIYGSEAITARSLRFAAMLRTSMIGGRMFPPNTNPGSLTAGDGRAILFVGLAALHTSFLRLHNNVAARLQNMNRHWNADRIFQESRKIVGGIVQVITYQEFVPELIGDASKTILGAYNGYNPNVEIGVLNEFAAGAYRLHGMIQETYPLVNSQFQEVNRYRFIDGVNNINHVLNNIDAIYRGMMTVPVRSPQRLTTSVTERLFGGSVDMAAVNIQRGRDHGLRSYNDYRRFCNLRPITSFNDWPEVPDENVRQRIGQLYRTPDDLDFYVGGILEQPAAGSLLGATFACVIGKQFERLRDGDRFYYENPGVFTSPQLAELKRTTLSWVLCQTGDNMVRVGRRAFDIENGSRAVPCSSITGLNLEAWRE
What is the function of this protein?
Involved in hypodermal immune response against some types of bacterial infection.  Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3.  May play a role in cuticule biosynthesis.
What are the official names of this protein?
Peroxidase skpo-1, ShKT and peroxidase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. XPO subfamily.
Protein: SAE2_MOUSE
Sequence: MALSRGLPRELAEAVSGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFHPQANIEAHHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEANADQQNEPQLGLKDQQVLDVKSYASLFSKSIETLRVHLAEKGDGAELIWDKDDPPAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNKQPNPRKKLLVPCALDPPNTNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDVQIEDGKGTILISSEEGETEANNPKKLSDFGIRNGSRLQADDFLQDYTLLINILHSEDLGKDVEFEVVGDSPEKVGPKQAEDAAKSIANGSDDGAQPSTSTAQEQDDVLIVDSDEEGPSNSTDCSGDDKARKRKLEENEAASTKKCRLEQMEDPDDVIALD
What is the function of this protein?
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4.  It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity).
What are the official names of this protein?
SUMO-activating enzyme subunit 2, Anthracycline-associated resistance ARX, Ubiquitin-like 1-activating enzyme E1B, Ubiquitin-like modifier-activating enzyme 2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Protein: ACKA_COPPD
Sequence: MKILVLNAGSSSLKFQLFDMEDESVMAKGIVERIGLDKPFLSYSKGTDKIKFDKEEPINHKDALQWVLNTLTSHEYGVITTLQEIGAVGHRVVHGGEEFTGSVLITEEVIEALERNKNLAPLHNPPNLTGIYATKAVLPEVPMVGVFDTAFHATMPERAYLYALPIELYEKYKVRRYGFHGTSHRYVAMEAARRLGKTLSELRIISAHLGNGASVCAIQGGKSIDTSMGFTPLEGLVMGTRSGDLDPAIPIWMMRELGMSFDEVDNLLNKKSGVFGLVRGRSFDMRDIEDWMAAGDEEAKKAMEVYCYRLKKYIGGYAAVMGGVDVLIFTAGVGENSPIVREMVCEGLEFLGIKLDKEKNNSRGDAIISAADSKVVVMSIKTNEELMIARDTYEIVRGLT
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE3_PARP8
Sequence: MKLTPRERDKLLIFTAALLAERRRARGLKLNYPEAVALITAALMEAARDGKTVAEVMHYGTTLLTRDDVMEGVPEMIPDIQVEATFPDGTKLVTVHHPIP
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAH_SACD2
Sequence: MATYAVGDIQGCYRALKLLLKKVKFNADNDHLWVAGDLVNRGPESLKSLRYIKKLGPSATLVLGNHDLHLLAHAYGVRTLNPKDTLAPILTAKDSDELLEWLQAQPLLHYDAEFDAVLVHAGIPPIWSIENALNYALEVEQALSTTQTAAAFFVDMYGNQPDVWQPSLEGTARLRLITNYLTRMRFCSPTGKLELQTKNAPSLPPTGFAPWYTHKHNKWGNTKILFGHWAALMGETRSKQFIGLDTGCVWGGALTMMRLEDGQFFAVDCPC
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: HUTG_BACSU
Sequence: MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPLSKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHHHIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTEDGGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKGLIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQQPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase, N-formimino-L-glutamate formiminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: SCLS_SALSC
Sequence: MSLAFNVGVTPFSGQRVGSRKEKFPVQGFPVTTPNRSRLIVNCSLTTIDFMAKMKENFKREDDKFPTTTTLRSEDIPSNLCIIDTLQRLGVDQFFQYEINTILDNTFRLWQEKHKVIYGNVTTHAMAFRLLRVKGYEVSSEELAPYGNQEAVSQQTNDLPMIIELYRAANERIYEEERSLEKILAWTTIFLNKQVQDNSIPDKKLHKLVEFYLRNYKGITIRLGARRNLELYDMTYYQALKSTNRFSNLCNEDFLVFAKQDFDIHEAQNQKGLQQLQRWYADCRLDTLNFGRDVVIIANYLASLIIGDHAFDYVRLAFAKTSVLVTIMDDFFDCHGSSQECDKIIELVKEWKENPDAEYGSEELEILFMALYNTVNELAERARVEQGRSVKEFLVKLWVEILSAFKIELDTWSNGTQQSFDEYISSSWLSNGSRLTGLLTMQFVGVKLSDEMLMSEECTDLARHVCMVGRLLNDVCSSEREREENIAGKSYSILLATEKDGRKVSEDEAIAEINEMVEYHWRKVLQIVYKKESILPRRCKDVFLEMAKGTFYAYGINDELTSPQQSKEDMKSFVF
What is the function of this protein?
Involved in the biosynthesis of labdane-type diterpenoid including sclareol, a diterpene-diol that is used as fragrance and flavoring, and has anticancer effects (able to kill leukemic and colon cancer cells by apoptosis) (Probable).  Sclareol can also be used as synthesis precursor of ambergris substitution fragance products such as ambrox (Probable).  Terpene synthase that catalyzes the conversion of 8-hydroxy-copalyl diphosphate to sclareol (PubMed:23113661, PubMed:22834731).
What are the official names of this protein?
Sclareol synthase, chloroplastic, ScSCS, SsSS, Diterpene synthase 1132, SsTps1132.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DPOL_VAR67
Sequence: MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLAPPPFNARPMGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRNIQNATMDEFLNISWFYISNGISPDGCYSLDDQYLTKINNGCYHCGDPRNCFAKEIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLQIAKQLLELTFDYIVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVHLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAVFAKVLTTGNYVTVDDIICKVIHKDIWENGFKVVLSCPTLTNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFGYKASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSSNRLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYKIIANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINSRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKIYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHLNYKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSRPTFYEA
What is the function of this protein?
Catalyzes DNA synthesis.  Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral OPG148 and OPG116 proteins, thereby forming the DNA polymerase holoenzyme.  Displays 3'- to 5' exonuclease activity.  Might participate in viral DNA recombination.  Does not perform OPG116/D4synthesis across an abasic site.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: GCH4_NEIMB
Sequence: MQLLKASDIISHLQIDGIFPGGNAIPCTHLNNYMNIKEKQLMNTIADVQSSRDLRNLPINQVGIKDLRFPITLQTAEGIQSTIARLTMTVYLPAEQKGTHMSRFVALMEQHAEALDFAQLRKLTTEMVALLDSRAGKISVSFPFFRKKTAPVSGIRSLLDYDVCLTGEIKDGAYGHSMKVMIPVTSLCPCSKEISQYGAHNQRSHVTVSLTADAEVGIEEVIDYVEAQASCQLYGLLKRPDEKYVTEKAYENPKFVEDMVRDVATSLIADKRIKSFVVESENFESIHNHSAYAYIAYP
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: CP1A1_RAT
Sequence: MPSVYGFPAFTSATELLLAVTTFCLGFWVVRVTRTWVPKGLKSPPGPWGLPFIGHVLTLGKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIANGQSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASSCYLEEHVSKEAEYLISKFQKLMAEVGHFDPFKYLVVSVANVICAICFGRRYDHDDQELLSIVNLSNEFGEVTGSGYPADFIPILRYLPNSSLDAFKDLNKKFYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQDRRLDENANVQLSDDKVITIVFDLFGAGFDTITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTIRDTSLNGFYIPKGHCVFVNQWQVNHDQELWGDPNEFRPERFLTSSGTLDKHLSEKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKVDMTPAYGLTLKHARCEHFQVQMRSSGPQHLQA
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions (By similarity).  Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (By similarity).  Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:20972997).  Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system.  Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (By similarity).  May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues.  Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (By similarity).  May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (By similarity).
What are the official names of this protein?
Cytochrome P450 1A1, CYP1A1, CYPIA1, Cytochrome P450 form 6, Cytochrome P450-C, Cytochrome P450-P1, Cytochrome P450MT2, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
[Cytochrome P450 1A1]: Cytoplasm. SUBCELLULAR LOCATION: [Cytochrome P450MT2A]: Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Cytochrome P450MT2B]: Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: CAMP_MACMU
Sequence: MKTQRNGPSLGRWSLVLLLLGLVMPLAIVAQVLSYQEAVLRAIDGINQRSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQKSPEDCDFKEDGLVKRCVGTVILNQARDSFDISCDKDNRRSARLGNFFRKVKEKIGGGLKKVGQKIKDFLGNLVPRTAS
What is the function of this protein?
Exhibits antimicrobial activity against E. coli and B. megaterium (in vitro).
What are the official names of this protein?
Cathelicidin antimicrobial peptide, 18 kDa cationic antimicrobial protein, CAP-18, rhCAP-18.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YCAR_ECO57
Sequence: MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS
What are the official names of this protein?
UPF0434 protein YcaR.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: RECR_SALRD
Sequence: MQYTSESVETLVEQFTKLPTIGKKTARRLANYVLKMPQEEVETIANALTSVKEDVQRCSTCYVVADQDPCPICGSDKRDASTICVVEESSDLTAIEQTNEYRGVYHVLGGVISPLDGVGPDDLRVHELATRIDPSFEDTAADAAPEPNTTPDGEADAEAPPSENGGADEAESGVDEVILAVNPNVEGDTTAYYISQLLEPFDVRVTRIARGLPIGGDLEYADEATLSRALEGRGHVD
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: GATB_NEUCR
Sequence: MPRIPTVELSRYLLTGHIASPGCLRARAALPGKNTRVALGGAPLPSRQLQPRQHARYLTTETSFANPSATTSSPAAAAPFRKQLKEQAKALKKSGHKKKKSSDNQTVPGWELTVGIEIHAQLNTAHKLFSPATTSFNDPPNTHVAPFDLALPGSQPLFQPATLIPAVRAALALNCSIQPVSRFDRKHYFHWDQPSGYQITQFYEPFAKDGFITLYARDGIAAEDGEEIKVGIKQVQMEQDTAKTTAQPGDVQWLDFNRVGVPLIEIITLPEIHHPATAAALVRKVQMVLASVDACVSGLEEGGLRADVNVSVRRTDDPSGKLGTRTEIKNLSSFKAVEDAIIAERDRQIELLEEGGEVKGETRGWSLGSTETRRLRGKEGEVDYRYMPDPDLGPVVIGEDLVARLRETMGVLPDQEADQLMERYNLSAKDALSLMLLDGGARIQYFYNVLDSLEERLVADGQAVPEGAEHATLAANWCLHELGKLTDSASSSSCSDPDVLEGLAMTPLGESPLVPSSSLAAILHHLYSRTITAKVAKDLLWAVYRGEIPEGGTTSYIDTHGLWFKELPEEEYAKLADEVIQGEEKILGEFLRWKQGKMKAYPQGKLMFLVGKMMRGGPEGRVEASGAERVLRRRIEEVYLPELEKGE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial, Glu-AdT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CLPX3_METCA
Sequence: MSSDPPAKTQHCSFCGIEQGRDTPLIAGIEGQICEACVRLAEQVVANWGRKRSMAELHGNVPKPEDIKRHLDQYVIGQELAKEILSVAVYNHYKRLRHESREILGLAGSDTEVQVGKSNILMIGPTGTGKTLLASTLARIVGVPFVVADATTLTQAGYVGDDVENILVRLLEAADGSVERAEWGIVYIDEVDKLAKSPEMAINTRDISGEGVQQALLRFVEGSQVKVAARGRRREGSGGGEEVTIDTRNILFIAGGAFPGLERHVEKRIGPPRGEIGFHAPVQDAKRPLLEELLAEIQPEDLRRFGLIPEFIGRFPVIAPLEPLDEAAFVRILTEPRDALVRQYQKLFAYEGVELVFTEPAIRRIAARTIERDTGARGLRSIIEHILRRPMFEIPSQSDVRQCVVDADTVDGKAPVTLVRAEEEAGGARLAAGEV
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX 3.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL34_SHIFL
Sequence: MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.