PharMolix/UniProtQA huggingface dataset:
Protein: CLPP3_NOSS1
Sequence: MPIGVPKVPYRMPGGQFTDWISIYDRLYRERIIFLGRDVDDEIANQIIAVMLYLDSEDPGKDIYLYINSPGGMVTSGLAIYDTMQHIKSDVVTICVGLAASMGSFLLAAGTKGKRMALPHSRIMIHQPSGGTRGQATDIEIEAREILRIRHQLNQIYANNTSQPLAKIEKDMDRDFFMSAQEAMEYGLIDRVIEERV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
Probable ATP-dependent Clp protease proteolytic subunit 3, Endopeptidase Clp 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_YERE8
Sequence: MSSIKLIVGLANPGAEYAQTRHNAGAWYVDLLALRHNQQLKEESKFFGYTARLNLAGQDVRLLVPSTFMNLSGKAVAAMAGFYRILPEEILVAHDELDIPPGVAKLKLGGGNGGHNGLKDIQSKLGNNPNFYRLRIGIGHPGDKSKVTGFVLGNPPASEQTLIDDAIDESIRCTEVLLKEDITKAMNRLHSFKAGAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_SHIBS
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLSKELTLPQPVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KSHA_MYCTU
Sequence: MSTDTSGVGVREIDAGALPTRYARGWHCLGVAKDYLEGKPHGVEAFGTKLVVFADSHGDLKVLDGYCRHMGGDLSEGTVKGDEVACPFHDWRWGGDGRCKLVPYARRTPRMARTRSWTTDVRSGLLFVWHDHEGNPPDPAVRIPEIPEAASDEWTDWRWNRILIEGSNCRDIIDNVTDMAHFFYIHFGLPTYFKNVFEGHIASQYLHNVGRPDVDDLGTSYGEAHLDSEASYFGPSFMINWLHNRYGNYKSESILINCHYPVTQNSFVLQWGVIVEKPKGMSEEMTDKLSRVFTEGVSKGFLQDVEIWKHKTRIDNPLLVEEDGAVYQLRRWYEQFYVDVADIKPEMVERFEIEVDTKRANEFWNAEVEKNLKSREVSDDVPAEQH
What is the function of this protein?
Involved in the degradation of cholesterol.  Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A.  KSH is also able to use 4-androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC), 3-oxo-23,24-bisnorcholesta-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) as substrates.
What are the official names of this protein?
3-ketosteroid-9-alpha-monooxygenase, oxygenase component, 3-ketosteroid-9-alpha-hydroxylase, oxygenase component, KSH, Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase, Rieske-type oxygenase, RO.
Protein: RT27_SCHPO
Sequence: MASKAILEELNILSSKIFGTQYKSNNSRTGRKFVVQELKGAKLKSYYPATINYRQLRTLLNDKTFPDSDEELRMEIRKGRIRQGKGASKSKKK
What is the function of this protein?
Involved in mitochondrial genome encoded proteins translation.
What are the official names of this protein?
37S ribosomal protein S27, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS33 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: BBLN_BOVIN
Sequence: MSGPNGDLGTPVEAGAEGEEDGFGEAEYAAINSMLDQINSCLDHLEEKNDHLHARLQELLESNRQTRLEFQQQLGETPSDASP
What is the function of this protein?
Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology.
What are the official names of this protein?
Bublin coiled-coil protein, UPF0184 protein C9orf16 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0184 (EST00098) family.
Protein: HD6_ENCCU
Sequence: MTNGRKMEYKLVDSEKDIERSYEPRRKPKRSRIQLHDWQSMLLEHSFRMNPYPDRIEKYNLFLKTKIPMKNVKIWFQNRRAREKSFYEEAVEVHRDGRRAGHRSLGSRSALFAEEFQYRRY
What are the official names of this protein?
Homeobox protein HD-6, EcHD-6.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH10_DESAL
Sequence: MKLQPLADRILVKRLAEETKTKGGIIIPDTAKEKPAEGEIVAVGPGRNAEDGTKIALEVKVGDRVLFGKYSGTEVKIEGEEYLIMREDDVLGIVQ
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_GRAFK
Sequence: MKFTATQIAEILDGKVEGNPEAEVSELAKIEEGSEGSLTFLSNPKYTSFLYTTNASVTIVNDDFEVEQPVNTTLIKVKDAYKAFSTLLEYYNQIKLNKSGIEQPSHISESAKYGEGLYLGAFAYIGENVSIGENVKIYPNVYIGDNVKIGNNVTLFPGVKVYSESLIGSEVTIHSGVVIGADGFGFSPGDTGEYSKVPQIGNVIIEDYVDIGAGTTIDRATLGSTIIRKGAKLDNHIQIAHNVEIGENTAIAAQTGIAGSTKIGKNCLIGGQVGIAGHLTIGNRVKIQAQSGIGRDIKDDEMLQGSPAIGYSDYNKSYIHFKNLPKTMNIIHQLEKKINNG
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: CWP24_TOBAC
Sequence: EQVGSQAGGAYXM
What are the official names of this protein?
32 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: HIS5_SYNE7
Sequence: MASTPQIAVVDYDMGNLHSACKGLEAAGANPIVTADPATILAADGVLLPGVGAFDPAMDHLRDRQLIEPLHQAATSGKPFLGICLGLQLLFEASEEGQSAGLGILPGRVQRFRSEPGLVIPHMGWNQLQLQQPDCPLWQNLGADPWFYFVHTYYVVPSEPTLTAATVQHGSQPVTAAIARDRLWAVQFHPEKSAKAGLQLLANFVTQVAAAQLQTVA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQE_XANOP
Sequence: MTTAPPPLSVLLELTHRCPLACAYCSNPIALAALREEMDTAGWRSLLEQAAEMGVLQAHFSGGEPMLRKDLPELVAHARALGLYSNLITSGVAGGEPMLDQLQAAGLEHVQLSVQDVDPAGADRIAGYRNSLPKKRDFAATVRARGLPLTINAVLHRHNAERVPGMIALALEWQAERIEVAHTQYYGWGLRNRAALMPSREQLMATIEAVDTARRELGDRLAIDFVTPDYYARQPKPCMGGWGQRFVNISPRGDVLPCHAAETIEGMRFDNLRERALADIWNNGEAFVRFRGTAWMPELCQGCPKREIDWGGCRCQALALSGNAATLDPVCERSPAHAQVRATAEREAAAPAPEFIYRRPERPAPATADTLE
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: RK4_PORPU
Sequence: MTVKTQLNYQVYNWEGQVSGNADLNLKISKDSGMYLVHRALVKQSNEKRQGSANTKTRSEVRGGGRKPWRQKGTGRARAGSIRSPLWRGGGVIFGPKPRSFAKKMNKKESQLALRTALNNKSVNTLVVENFDTYFQKPKTKLFIEAITRWNLDLNKKLLVIVDKKDLNVYLSIRNLYNVEIISADTLNIMALLAAHKVIITVDALSKIQEVYNG
What is the function of this protein?
Probably binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MURE_PSEMY
Sequence: MPMPLNQLLPAAESGVLIRELTLDSRKVRPGDLFLAVPGTQQDGRVHIADAVARGAAAVAFEAEGAAPMHAESAVLVPVKGLAGQLSAIAGRFYGEPSRALHLIGVTGTNGKTSVSQLLAQALDLLGERCGIVGTLGTGFHGALEQGKHTTPDPVGVQATLASLKQAGARAVAMEVSSHGLDQGRVAALEFDVAVFTNLSRDHLDYHGSMEAYGAAKAKLFAWPNLRCRVINLDDAFGRELAQQAHDSRLIGYSLSDASAFLYCSEAQFDDHGVRARLVTPRGEGVLRSNLLGRFNLSNLLAVVGALLGMDYGLDEILKVLPQLQGPAGRMQRLGGGDKPLVVVDYAHTPDALEKVLEAMRPHVQGRLVCLFGCGGDRDRGKRPLMAAVAERLADVVWVTDDNPRSEDPAQIVADIRAGFCAPEQVQFIHGRGDAIARLIAQAEAADVLVLAGKGHEDYQEITGVRHPFSDLIEANEALAAWEAAHA
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PALY_RHOMI
Sequence: MAPSVDSIATSVANSLSNGLHAAAAANGGDVHKKTAGAGSLLPTTETTQLDIVERILADAGATDQIKLDGYTLTLGDVVGAARRGRSVKVADSPHIREKIDASVEFLRTQLDNSVYGVTTGFGGSADTRTEDAISLQKALLEHQLCGVLPTSMDGFALGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRIVVLEALTNFLNHGITPIVPLRGTISASGDLSPLSYIAASITGHPDSKVHVDGKIMSAQEAIALKGLQPVVLGPKEGLGLVNGTAVSASMATLALTDAHVLSLLAQALTALTVEAMVGHAGSFHPFLHDVTRPHPTQIEVARNIRTLLEGSKYAVHHETEVKVKDDEGILRQDRYPLRCSPQWLGPLVSDMIHAHAVLSLEAGQSTTDNPLIDLENKMTHHGGAFMASSVGNTMEKTRLAVALMGKVSFTQLTEMLNAGMNRALPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVSTHVQPAEMGNQAINSLALISARRTAEANDVLSLLLATHLYCVLQAVDLRAMEFEHTKAFEPMVTELLKQHFGALATAEVEDKVRKSIYKRLQQNNSYDLEQRWHDTFSVATGAVVEALAGQEVSLASLNAWKVACAEKAIALTRSVRDSFWAAPSSSSPALKYLSPRTRVLYSFVREEVGVKARRGDVYLGKQEVTIGTNVSRIYEAIKSGCIAPVLVKMMA
What is the function of this protein?
Catalyzes the non-oxidative deamination of L-phenylalanine to form trans-cinnamic acid and a free ammonium ion (By similarity).  Facilitates the commitment step in phenylpropanoid pathways that produce secondary metabolites such as lignins, coumarins and flavonoids (By similarity).
What are the official names of this protein?
Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_ACTPJ
Sequence: MAERKYFGTDGVRGKVGQFPITPDFALKLGWAAGKILATQGTKQVLIGKDTRISGYMLESALEAGLAAAGLSAAFVGPMPTPAIAYLTRTFRAEAGIVISASHNPYYDNGIKFFSSVGEKLPDEVEEAIEALLDQPMDCVESAQLGKAMRINDAAGRYIEFCKGTFPANASLKGYKIVVDCANGATYHIAPNVMRELGAEVIEIGTKPDGLNINEKCGATDIKALQKVVVESGADVGLAYDGDGDRIMMVDHLGNKVDGDQILFIIAREALRSGKLHGGVVGTLMSNMGLEVALKHLAIPFTRANVGDRYVLEQLKEKGWKLGGENSGHIIVLDKNTTGDGIIASLEVLAAMEAHKMSLNDLARAVPLFPQVLINVRFEGGKNPLESDAVKAVAADVEKRLAGKGRILLRKSGTEPLIRVMVECEDGALAQSCAEEIVEAVKSN
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: BETA_YERPS
Sequence: MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLDCLPYFRKAETRDVGPNDFHGGEGPVSVTTPKIDNNPLFHAMVAAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVSYLKGDAGTGQTAHARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHLEMYLQYSCKQPVSLYPALLWFNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVKSKDPRQHPSILFNYMSNEQDWHEFRDAIRITREIIAQPALDPYRGREISPGANVQSDDELDAFIREHAETAYHPSCSCKMGDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKSNAAYFIAGDTPARTSPVRHSLPVTSYP
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: FIBA_CHLAE
Sequence: ADTGEGDFLAEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1077_STRPQ
Sequence: MTTKKAYMYVLECVDKTLYTGYTTDLKKRLATHNAGKGAKYTRYRLPVSLLYYEVFDSKEAAMSAEALFKKRKTRSQKLAYIATHQKEKKNH
What are the official names of this protein?
UPF0213 protein SPs0786.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: P5CR2_PONAB
Sequence: MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADVQAGHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTLTPSSPGKLLTRSLALGGKKD
What is the function of this protein?
Housekeeping enzyme that catalyzes the last step in proline biosynthesis.  In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+).  Can utilize both NAD and NADP.  Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity).  Involved in cellular response to oxidative stress (By similarity).
What are the official names of this protein?
Pyrroline-5-carboxylate reductase 2, P5C reductase 2, P5CR 2.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: ZN511_MOUSE
Sequence: MLLPPALYSRLAGEPGAAEPLPVERNPAAGEAPFRFAPRAVRFPRDHEFFEDGDVQRHLYLQDMLTQVSETPEKSMVPEFTCQVAGCCQVFAAIEDYQHHYHMMHGNTCSFCNRAFPSGHLLDVHILEWHDSLFQILAQRQDMYQCLVESCPEKFKTSQDRKDHMVRLHLYPADFRFDKPKTNRGPAMPAAADAATRAPTDDSDAMEICSEPAAPPPCRRTYSHRSV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 511.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METN_VIBPA
Sequence: MIEIKNVNKVFYQGSKEILALKDINLHIAKGTIFGVIGSSGAGKSTLIRCVNMLEAPSSGSIIVDGVDLTTLSKKQLVETRRNIGMIFQHFNLLSSRTVFDNVALPLELAGKDKSQITTKVTELLKLVGLADKHESYPSNLSGGQKQRVAIARALASDPSVLLCDEATSALDPATTQSILELLKEINRKLNITILLITHEMEVVKSICHEVAIIGGGELVEKGTVGDIFAHPKTELAHEFIRSTLDLSIPEDYQARLQPNRVEGSYPLVRMEFTGATVDAPLMSQISRKYNIDVSILSSDLDYAGGVKFGMMVAELFGNEQDDSAAIEYLREHNVKVEVLGYVL
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS10_ECOL6
Sequence: MQNQRIRIRLKAFDHRLIDQATAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHLRLVDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ADIP_MOUSE
Sequence: MGDWMTVTDPVLCTENKNLSQYTSETKMSPSSLYSQQVLCSSVPLSKNVHGVFGVFCTGENIEQSISYLDQELTTFGFPSLYEESKSKEAKRELNIVAVLNCMNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLKEQLETSRREMIGLQERDRQLQCKNRSLHQLLKNEKDEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLVMNKKDKNIAMDVLNYVGRADGKRGSWRTDKTEARNEDEMYKILLNDYEYRQKQILMENAELKKVLQQMKKEMISLLSPQKKKPRERAEDGTGTVAISDIEDDSGELSRDSVWGLSCDTVREQLTNSIRKQWRILKSHVEKLDNQASKVHSEGLNEEDVISRQDHEQETEKLELEIERCKEMIKAQQQLLQQQLATTCDDDTTSLLRDCYLLEEKERLKEEWTLFKEQKKNFERERRSFTEAAIRLGLERKAFEEERASWVKQQFLNMTNFDHQNSENVKLFSAFSGSSDPDNLIVHSRPRQKKLHSVANGVPACTSKLTKSLPASPSTSDFRQTHSCVSEHSSISVLNITPEESKPSEVARESTDQKWSVQSRPSSREGCYSGCSSAFRSAHGDRDDLP
What is the function of this protein?
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs).  May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (PubMed:12446711).  Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles.  The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity).  Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (PubMed:22027834).  Involved in ciliogenesis (By similarity).  It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (By similarity).
What are the official names of this protein?
Afadin- and alpha-actinin-binding protein, ADIP, Afadin DIL domain-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the ADIP family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Not found at cell-matrix AJs.
Protein: DDL_GRABC
Sequence: MSIRRVVVLYGGISEERAVSLISGQQVVAALREAGYEVTPIEVGADLRDTIAALTPAPDVVFNALHGRFGEDGAIQGVLDWLNIPYTHSGVRASAIAMDKAAARTAFLAAGLPVAEGRLVTVEELAEQDPLPRPFVIKPANEGSAVGVHILHEGDNRRTEIARSWSFGGQALVEEYIPGRELTVGVLNDRALTVTDIRPRSAFYDYESKYAEGGSRHILPAQMHPDAFKRALDVALAAHHALGCRGATRSDFRYDDTRAEPGRLVLLEVNTQPGLTPTSLLPEQAALMGMDFVSLCRWMVEQATCRA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PI4P1_HUMAN
Sequence: MTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPADIGDLREQLVEENTGSLSGPAKDFYQREFDFFNKITNVSAVIKPYPKGDQRKKACLSALSEVTVQPGCSLPSNPEAIVLDVDYKSGTPM
What are the official names of this protein?
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
Protein: COX2_SCHPO
Sequence: MLFFNSILNDAPSSWALYFQDGASPSYLGVTHLNDYLMFYLTFIFIGVIYAICKAVIEYNYNSHPIAAKYTTHGSIVEFIWTLIPALILILVALPSFKLLYLLDEVQKPSMTVKAIGRQWFWTYELNDFVTNENEPVSFDSYMVPEEDLEEGSLRQLEVDNRLVLPIDTRIRLILTSGDVIHSWAVPSLGIKCDCIPGRLNQVSLSIDREGLFYGQCSELCGVLHSSMPIVVQGVSLEDFLAWLEENS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRUB_FRATT
Sequence: MKKNRLNLNGVVVINKVKDISSNKVLQQLKYLFNAQKAGHTGTLDPMATGVLPICFGRATKIAQYLLDADKEYIATIRLGIETDSGDAEGEIIAKSINIPELSAEYLETVLAKFRGDVVQIPPMYSALKYNGQPLYKLAREGKTVEVKSRNIKIYELELLEFNIDSLKIRVKCSKGTYIRSLAIDIGKTLGCGGHLIALQRTQSGPFKLSEAFRLEQLKDLSFEQKIASITNIESVFIDKPIYSLLEEEKDDLYKRGLFADKPHLDGTVRIYDVEKFVAIAEFDKGKLINKKFFDQDILISE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: Y1313_MYCBO
Sequence: MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPYSYDDLDFNALLQPPGTKHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATVGAISGYFGGWRDRTLMWVVDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMISSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILAETGLSFLGFGIQPPDVSLGTLIADGTASATAFPWVFLFPASILVLILVCANLTGDGLRDALDPASRSLRRGVR
What are the official names of this protein?
Putative peptide transport permease protein Mb1313c.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.