PharMolix/UniProtQA huggingface dataset:
Protein: EBRB_BACSU
Sequence: MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAFTFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLNQSKAHAEDKKQTACE
What is the function of this protein?
Part of a multidrug efflux pump.  Confers resistance to cationic lipophilic dyes such as ethidium bromide, acriflavine, pyronine Y and safranin O.  The efflux is probably coupled to an influx of protons (By similarity).
What are the official names of this protein?
Multidrug resistance protein EbrB.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. EbrA/EbrB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UPPP_DESAL
Sequence: MHWLEVVLLGVIQGLTEFLPVSSSGHLVLFQGLMGMEEPELLLDICLHVGTLAAVLWVFFAQILEAAKGFFRFCAAAPKGKAAMVQVWTTDQDARMALLIIIGTIPTGFIGMGFHKIADKLFASPVLAGAMLLITGALLWATRYVRTEGKLLPKVTWGNALTVGTIQGLAILPGISRSGSTICAALFLGVDREVAARYSFLLSIPAIVAALILEVADASAAAHPPVSMLLLGGIVSAFTGLAALKWLLAIVRKGSLWWFAPYCWLVGATVLVANFV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TCR_BACCE
Sequence: MNTSYSQSNLRHNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVFFMLFTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLGGLSFTKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIPLLDQRLLPMEVDQSTYLYSNLLLLFSGIIVISWLVTLNVYKHSQRDF
What is the function of this protein?
Resistance to tetracycline by an active tetracycline efflux.  This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells.  This protein functions as a metal-tetracycline/H(+) antiporter.
What are the official names of this protein?
Tetracycline resistance protein.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOZ_CAMJJ
Sequence: MDKRIEEVAAKALEKMGNDRYRLSLVVAKRAEQLANGATPLVDFDKNKNKLADIALYEIAENKITLEGLVETNR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RNPH_SHELP
Sequence: MRPSDRTPAQSRPVTITRQFTAHAEGSVLIEFGETKVLCTASFTEGVPRFLKGQGQGWVTAEYGMLPRSTHSRMDREAARGKQSGRTQEIQRLIGRALRAAVDMKALGENTIVIDCDVIQADGGTRTAAITGACVALVDALNWARGKGLIKTNPLKFLIAAVSVGIYKGEPICDLEYVEDSAAETDMNVVMTETGKIIEIQGTAEGEPFSHEELLSLLDLAKHGIREIVDVQKAALS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: HISX_SHIBS
Sequence: MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPARIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARDLVDGITSAGSVFLGDWSLESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: Y1434_DEIRA
Sequence: MPFVIVSGLSGSGKSTALRTLEDAGFFITDNLPPELWNAMHDLVTARGIENVAVSTDTRTREFLAALEPSYVRLSRRREDLRVLFLEANAEVLLGRYNLSRREHPLGETLMVDFARERELLAPLRGIADTVIDTTDLSAAQLSQRVMHLFRLEHAFTLRLLSFGFKHAPPRDADLVLDVRSLPNPYYDETLRSKSGRQPDVAAYVFRDAEAEQFYGELRHFVQTAAERARASGRHSYTVGIGCTGGQHRSVAVAERLLRELQASSIETELMDHRDMREGGEPT
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein DR_1434.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: NUF2_DANRE
Sequence: MSENTFPVYKVDVIVQFYRTEVLTGQESKHFTKNDLTPTPKPESVQRLYMRILQLLFRFRPECHYTVPLSENIQYPMLYESFAPIMSVYMRMCQFLPVCRVYDFSLSDLLNPKTKRTITILSAIQNFLHFRKQRLEITAAHQQSFRADMDRLQAYTREIKEAEKKIEKLTTIPPEQQAEAKELASALAELSTNTQHEYQDVSAINEKVAQFKTEIAELSQKLTQRKVEVATLKDEISKLKSQIVESPEELKNEMERMRETAKNIKMSKELADERLVELQMLVQCASQVEAEIQILLKQLQDLQSSMSKTKQRKEEVQSLEVMNESLQKELKSLSSEEAQLKRALTMKLDKESKQQIRRQKKKEVKDQQVKNIYGQYDKMHQKRQEIVKKIEECNRETKQFKEKMQALRENCNQRTQKAQEIYERLLTTLEQYHKRIEKILVETNADALKMKSHF
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Kinetochore protein Nuf2, Cell division cycle-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the NUF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
Protein: METAA_HYPNA
Sequence: MPIRIPDTLPARETLLKEGVAVMTETDAVRQDIRPLQIALLNLMPNKIRTETQIARLIGASPLQVELTLVRVGGHTPKNTSQEHLISFYQTWEEIRERKFDGFIITGAPIEQMPFEEVNYWEELTQIFDWTQTNVHSPFYICWGAMAAAYHFHGLPKYQLEAKAFGVFRHRNLDLASPYLSGFSDDFAIPVSRWTEVRRADVLERQSLRLLIDSDDTGPCLLEDRARRSLYMFNHVEYDSFSLKEEFERDREAGKQIQVPFGYYPGDDPARQPLNRWRSHAHLLFGNWINQTYQSTPFSLDEIGQ
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_ALIF1
Sequence: MAKLTKRMRNIREKVEVTKEYDINEAVALLKELATAKFTESVDVAVNLGIDARKSDQNVRGATVLPHGTGREIRVAVFTQGANAEAAKEAGADLVGMEDLAELVKKGEMNFDVVVASPDAMRVVGQLGTILGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFDAAQLKENLEALLVALKKAKPTSAKGTFVKKVSISTTMGAGVSLDQATLNTQTN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: METK_MEDSF
Sequence: MATETFLYTSESVNEGHPDKLCDQISDAVLDACLEQDPDSKVACETCTKTNMVMVFGEITTKANVDYEKIVRNTCRNIGFVSDDVGLDADNCKVLVNIEQQSPDIAQGVHGHLTKRPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTEVRKNGTCPWLRPDGKTQVTIEYFNDKGAMVPIRVHTVLISTQHDETVTNDEIAADLKQHVIKPVIPEKYLDEKTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVANGLARRCIVQVSYAIGVPEPLSVFVDSYGTGKIPDKEILNIVKETFDFRPGMISINLDLKRGGNNRFLKTAAYGHFGRDDADFTWEVVKPLKGGKLATA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase, MAT.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYTD_HUMAN
Sequence: MMWPMHTPLLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSVQCALDFAISEYNKVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFCSFQINEVPWEDKISILNYKCRKV
What is the function of this protein?
Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity.  The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.
What are the official names of this protein?
Cystatin-D, Cystatin-5.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXH_YERPN
Sequence: MSTLFIADLHLSVQEPAITAGFLHFIQREAIHADALYILGDLFESWIGDDDPEPLYRQVAAALKSLQQQGVPCYFIHGNRDFLLGKRFAEESGMVLLPEENVVELYGRKILILHGDTLCTDDTDYQHFRKKVHNPLIQKLFLWIPLRLRLRIAAYMRNKSQQNNSGKSERIMDVNSKAVIDAFLRHDVSWMIHGHTHRPAIHSVELPMVTAHRVVLGAWHVEGSMVKVTADNVELITFPF
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RT14_HUMAN
Sequence: MAAFMLGSLLRTFKQMVPSSASGQVRSHYVDWRMWRDVKRRKMAYEYADERLRINSLRKNTILPKILQDVADEEIAALPRDSCPVRIRNRCVMTSRPRGVKRRWRLSRIVFRHLADHGQLSGIQRATW
What are the official names of this protein?
28S ribosomal protein S14, mitochondrial, MRP-S14, S14mt, Mitochondrial small ribosomal subunit protein uS14m.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: CH10_SALTY
Sequence: MSIRPLHDRVIVKRKEVESKSAGGIVLTGSAAGKSTRGEIIAVGKGRILDNGTVQPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASNA_STRP8
Sequence: MKKSFIHQQEEISFVKNTFTQYLIAKLDVVEVQGPILSRVGDGMQDNLSGTENPVSVNVLKIPNATFEVVHSLAKWKRHTLARFGFNEGEGLVVNMKALRPDEDSLDQTHSVYVDQWDWEKVIPDGKRNLAYLKETVETIYKVIRLTELAVEARYDIEAVLPKKITFIHTEELVAKYPDLTPKERENAITKEFGAVFLIGIGGVLPDGKPHDGRAPDYDDWTTETENGYHGLNGDILVWNDQLGSAFELSSMGIRVDEEALKRQVEMTGDQDRLAFDWHKSLLNGLFPLTIGGGIGQSRMVMFLLRKKHIGEVQTSVWPQEVRDSYDNIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPC_BACHK
Sequence: MAKKQNILSPIIRITFTFLVLCGLVYPLIVTGIAQAVMKDNADGSLIYNDKNEVIGSTLIGQNFTDPRYFHGRVSSIEYKAEASGSNNYAPSNPDLEKRVEKSIEEWKKQNPSVPVTEVPIDLVTNSGSGLDPDISPKAASVQVERISKLTNIPKETLDQLIKDQTEGAALGLFGETRVNVLKLNLELQKIMK
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: TPMT_ALISL
Sequence: MDQEFWQKKWASNVIGFHLPDTNPVLSEFWKALNPTREQTVFVPLCGKSMDLDWLAERHNSVSGVELSQIAVRAFFAERLYTPTVTTLSSTLELYDFDEFTIFAGDYFTAPIEATDLIYDRAALVALPKEMRSEYVQVLRSRLKEGGRILLVTLDYDQNEMSGPPFSVPEDEVRSLFSGMSITKLQRDEADADHPRIKKGLTRFAEEVWLIKS
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_RUEPO
Sequence: MFQDLHALHTRTSGRRILDLFAADLRRAERFSADLGEMRLDYSKTQIDDAIRAGLIALCDRAQLADKREAMFAGAPINETEGRAVLHTALRNLDGGPVHVDGAEVMADVRLTLARMRRFAEALRSGALPGAGGAITDVVNIGIGGSDLGPAMAVLALAPYHDGPRCHFVSNVDGAHIADTLRGLDPARTLVIVASKTFTTIETMTNARTARDWMQRGGGDPERQFAAVSTATDRTAAFGIPGDRVFGFADWVGGRYSLWGPIGLSLMIAIGPDDFDAFLRGAQEMDRHFQSAPWEKNLPVMLALTGIWHHQICGHPSRAVLPYDQRLARLPAYLQQLEMESNGKSVAMDGTALDQAAGPIVWGEPGTNGQHAFYQLIHQGKQVVPCEFMVAARGHEPDLAHHHRLLIANCLAQSEALMRGRPLDEARAIAAARGVAGDELERQARHRVFAGNRPSTTLIYPRLTPAMLGRIIALYEHRVFVEGVILGINSFDQWGVELGKELATSLGPVVDGTESAAAKDGSTAALVDYVLAHRDTDLT
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGJ_LACPL
Sequence: MQVLTNTKFETVAFQWPAGFYSDGIHIGLRRHKKDFGWLFSKVPASAAGTYTTNQFQAAPTKLTKQMIDQGHQLQGLLLNSAIANSCTGEQGWQNALQEQAWLANKLNVAPNLIGVASTGLIGAQLPMDKIKNGLPQLTPTKSDAVTYAVLTTDQHPKTVCVQCELSGQLVTLTGFAKGSGMIHPKMATMLGFVTTDAQIDGPVLQDMLSTNVDQTFNQITVDGDTSTNDMVVTLANGLADNPSLQAGTTDYDIFNQALHYVLGQLAKQIAADGEGATKLVECNVVHAATTFDGQQIAKAIVGSNLVKAAIFGEDPNWGRIISTIGATDADIDVATVDIEMNGVLLVQQSLAVDFDMAAVQATLRDNQIMIDVDLHHGTASGQAWGCDLTYNYVKINASYHT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3J_ASPFU
Sequence: MAPSKWDDEEDSSPPPPPPVVARRKFDDEEEEDVLDSWDAAEDSEVEREKAAKAAAAAAKAEAEAAAKKKSKAQRIEERKQERKKLAEANESDEDSEEDEAARRARLRRTEKEGDLKHAQDLFEDIDLNRNRGTPKAIVISDSADPTQAVDLSAMPLFKPTTKDQFTRLTSTLIPLLTAHSKKPHYALWAQEFTKQLVKELNSGDVKKIASALTTISNEKMREERAADKGNKKTKAAKTKVSLVASRDNKIDATPYDDDGLDDDDFM
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit J, eIF3j, Eukaryotic translation initiation factor 3 30 kDa subunit, eIF-3 30 kDa.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit J family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAS2_HUMAN
Sequence: MAKSKTKHRLCSQESSVSALLASCTLSGSNSSNSDGSFHYKDKLYRSASQALQAYIDDFDLGQIYPGASTGKINIDEDFTNMSQFCNYIYKPNNAFENLDHKKHSNFISCRRHTVNDIDSMSLTTDDLLRLPADGSFSYTYVGPSHRTSKKNKKCRGRLGSLDIEKNPHFQGPYTSMGKDNFVTPVIRSNINGKQCGDKIELLILKAKRNLEQCTEELPKSMKKDDSPCSLDKLEADRSWENIPVTFKSPVPVNSDDSPQQTSRAKSAKGVLEDFLNNDNQSCTLSGGKHHGPVEALKQMLFNLQAVQERFNQNKTTDPKEEIKQVSEDDFSKLQLKESMIPITRSLQKALHHLSRLRDLVDDTNGERSPKM
What is the function of this protein?
Might play a role in cell proliferation.
What are the official names of this protein?
Lung adenoma susceptibility protein 2.
What are the subcellular locations of this protein?
Secreted.
Protein: OCEF1_LEPLB
Sequence: GVVDILKGAAKDIAGHLASKVMNKL
What is the function of this protein?
Antibacterial peptide that inhibits reference strains of both Gram-negative bacteria (E. coli, P. aeruginosa, E. cloacae, K. pneumoniae, and A. actinomycetemcomitans) and Gram-positive bacteria (S. aureus) with relatively low potencies (MIC=25-400 uM) (PubMed:28115922) (By similarity).  Shows antifungal activity against C. lusitaniae (MIC=50. 25 uM), but no activity against C. albicans (PubMed:28115922).  In the presence of an alkaloid (bufotenine), inhibits cellular infection by the rabies virus (PubMed:26635873).  The peptide shows very low hemolytic activity against rabbit erythrocytes (PubMed:28115922) (By similarity).  The low amphipathicity of alpha-helices demonstrated by wheel projection as well as the low cationicity may explain the low antibacterial and hemolytic potencies (By similarity).
What are the official names of this protein?
Ocellatin-F1, OF1, Fallaxin.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Ocellatin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MOCOS_DROGR
Sequence: MGDYTAEFTPDEQALIDAEFARLSDSTYLDHAGTTLYAHNQVSDAAQQLQRDVICNPHTCRVTGDYVDQVRYKILEFFNTNADEYHVVFTANASAALRLVADHFDFGTNGNFHYCQENHTSVLGMRQLVSANRIYMLTKDQILLNNGTPAGATAAAATAHSDNSLVVFSAQCNFSGYKMPLTVIEKIQQDGLREPGKCIDCKLQSDPGQSNYYVCLDAASYAASSPLDLRRHRPDYVCLSFYKIFGYPTGVGALLVSKRGAELLKKRFYGGGTVNFAYPHTMEHQLRSTFHERFEDGTLPFLSIVELLQGFQTLQRLVPGRSMERISRHVHSLARYCEQQLLQMQYPNGAPLVTLYNHAGYEDRMQQGGIVAFNVRTAAGDYVGFGEIASVAALHRILLRTGCFCNVGACQHFMNLNGDAMDAIYKLAGRICGDYYDLLDGRPTGAVRVSFGYMTRLQDVDRLLQMLRDSYLSVKWHQRLDFIEQRVQQLPKLLQQRAQQLRPQLLQLAIYPVKSCAALKMPASALTDQGLQYDREWMIVDLNGMALTQKRCTDLCLIQPRIVADQLQLHFNGDGSTTFVSVPLSLTDQATNSARCQSKVCRQSVEGYDCGDEVANWLCQQLGLDGLRLLRQSAQRRAPGDRQQLSLVNQAQFLLVNRASVRSLGFEEPLDETVDRFRSNIVIDTGVPFEELEFGQLRIGEVLFQVEGPCQRCDMICINQRTGQRSPDTLTTIARIQSGKMRFGIYISRLPNENRMQPQLACGDPITVLR
What is the function of this protein?
Sulfurates the molybdenum cofactor.  Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
What are the official names of this protein?
Molybdenum cofactor sulfurase, MCS, MOS, MoCo sulfurase, Molybdenum cofactor sulfurtransferase, Protein maroon-like, Ma-l.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
Protein: PANB_BACP2
Sequence: MKTKLDFFKMKEQNEPIVMLTAYDYPSAKQAEKAEVDMILVGDSLGMVVLGLDSTIQVTIDDMIHHTKAVKRGAKDTFIVTDMPFMSYHYSLAETLKNAARIMQESGADALKLEGGDGVFESIQALTRGGIPVVSHLGLTPQSVGVLGGYKVQGKDHESAQKLIEDSLKCEEAGAIALVLECVPGELTKRITDMLKIPVIGIGAGAEADGQVLVYHDVVGYGVSRTPKFVKQYAQIDTLLEEALIQYTKEVKAHTFPEDKHTFHIKEEVLDGLYGGIKK
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_HALHL
Sequence: MSAVIALVGRPNVGKSTLFNRLTGSRDALVADHPGLTRDRQYGIVRHQGGHAVVVDTGGMGEELEGVGGCMHEQARAAIAGADAVVFLVDGQAGATVGDEEIAAELRRAQVPVFLAVNKTDGLDAGVAAADFHGLGLQPVHAIAATRGRGVGELLDAVFALLPPAEPDAVGSDGPGGIPVAMIGRPNVGKSTLVNRLLGEERVVVYDEPGTTRDSIAVPFERDGQHYTLIDTAGVRRRARVQETVEKFSVVKTLEAIERASVVMLVTDAQEGITEQDAHLAGHVLQAGRALVLVINKWDGLDPDQRRKVRRDLDLRFAFLGFARHHFVSALHGSGVGLLLESVERAHAAAHRDLATPELNDALQEALANHQPPLSRGRRIKLRYAHQGGHNPPVIVIHGNQVQRLPRAYMRYLENFFRDTFDLYGTPVRIECRASDNPFADKPNQLTERQRRRRQRVIHHAKKREKKRKRRR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: DUT_ACTP2
Sequence: MKQIDLKILDGRIGNEFPLPAYATEGSAGLDLRALTESALTVAPGQTVLIPTGISIYIADPNLAAVILPRSGLGHKNGIVLGNLVGLIDSDYQGPLMVSLWNRSDKPFTVEVGDRIAQLVFVPVVQARFNIVNDFAQTERGEGGFGHSGKQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: CAPSD_WHV3
Sequence: MDIDPYKEFGSSYQLLNFLPLDFFPDLNALVDTATALYEEELTGREHCSPHHTAIRQALVCWDELTKLIAWMSSNITSEQVRTIIVNHVNDTWGLKVRQSLWFHLSCLTFGQHTVQEFLVSFGVWIRTPAPYRPPNAPILSTLPEHTVIRRRGGARASRSPRRRTPSPRRRRSQSPRRRRSQSPSANC
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsids are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stuck in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg, p21.5.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus core antigen family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.