PharMolix/UniProtQA huggingface dataset:
Protein: SYI_RUTMC
Sequence: MSDYKSSLNLPATQFPMKANLANREGGFLKKWQNDGLYDQIRQQNQGKPKFVLHDGPPYANGDIHIGHTVNKVLKDMIVKSKSLSGFDAPYVPGWDCHGLPIEFNVEKKYGKVGVKIDASTFRSKCRKYADQQVLKQKQDFQRLGILSDWDNPYLTKDFQYESDIVRALGRIVKNGHVSKGYKPVHWCTECGSALAETEVEYKDNQSEAIDVKFRIIDDSVFNMNKPVSVVIWTTTPWTLPANEAVALHPELNYVLVDIGDEYLLLAQALVETSISRYGIEATIGEQTFSGSELEGLKIKHPFYDKQVPIILGEYVTIDAGTGAVHTAPAHGQEDFIVGLKYNLPVECLVDIKGVFFKETELLGGQFIFKANDSVIEILKQANTLVKHESLMHSYPHCWRHKTPVIFRATPQWFISMQKNGLIDTVNREISKVQWMPDWGKKRIELMMDSRPDWCISRQRFWGVPITLFVHKQTGELHPNTQALFVSIANRIEKEGIEAWFKSDAQDFIGNDANDYDKTTDILDVWFDSGVSHFTVLKARKELSNVADLYLEGADQHRGWFQLSLISSVAINGKAPYKNVLTHGFVVDKNGKKMSKSLGNVMSPQKIVNNLGADVLRLWIASTDYTSEMTVGDEILKRSADSYRRIRNTMRFMLANMQAFNPVEHLLDNKQMLDLDKWIVAKTANLQTQIIKAYEQYNFHHVVQLILNFCSNDLGGFYLDVIKDRQYTTQANSLARRSAQSALHHITEAMVRWLAPILSFTAEEIWQNMPSEKNTSIFLASWYQDLTFGYENKAIDITREISPFIRKQMEGMRGEKIIGSSLESEIDIYCETDIFSTLSQLDDELRFIFITSYIRIHSLNEKNDDCIKAIEGVFIKVSKSRHEKCVRCWHHREDVGNNAKHPELCGRCVENVDGKGEIRKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCD_STAAS
Sequence: MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNNMRQTLSEILKIHQEVTK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PITX2_XENLA
Sequence: MNSMKEPLHLDHLAGSRVAAASSHHHHHHHHQHQTVTLVSMASSLGQRSGECKSRLEVHTISDTSSPDTADKDKSHQTKNEDSSTDDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPSYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSSPNSISSMSMSSGMVPSAVTGVPGSGLNSLNNLNNLSNPSLNTAVPTSACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYATVQTPGSNLSACQYAVDRPV
What is the function of this protein?
May play an important role in development and maintenance of anterior structures and mediate left-right asymmetry.  Could play a role at the interface of lateral plate signaling and heart and gut morphogenesis.
What are the official names of this protein?
Pituitary homeobox 2, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, xPtx2.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYD_STRCO
Sequence: MHRYRSHTCGELRSSDVGTDVRLSGWLHNRRDLGGILFIDLRDHYGITQLVARPGTEAYEALDKLTKESTVRVDGKVVSRGADNINPDLPTGEVEVEVGEVELLGAAQPLPFTINTEDGVNEERRLEYRFLDLRRERMHRNIMLRTSVISSIRSKMVALGFNEMATPILTATSPEGARDFVVPSRLHAGRFYALPQAPQQFKQLLMISGFDRYFQIAPCFRDEDARADRSPGEFYQLDVEMSFVEQEDVFRPIEQLMTELFEEFGNGRHVTSPFPRIPFREAMLKYGSDKPDLRAQLELVDITDVFEGSEFKAFAGKHVRALPVPDVSGQPRRFFDQLGDYAVSQGAKGLAWVRVGEDGKLSGPIAKFLTEENVAELTKRLSLAPGHAVFFGAGEFDEVSKIMGAVRVEAAKRAGHFEENVFRFCWIVDFPMYEKDEETGKIDFSHNPFSMPQGGMDALENQDPLDILAWQYDIVCNGVELSSGAIRNHEPEIMLKAFEIAGYDAETVEREFAGMLRAFRFGAPPHGGIAPGVDRIVMLLADEPNIRETIAFPLNGNAQDLMMGAPTELDESRLRELHLTVRKPQPK
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_PARMW
Sequence: MTYSRVLLKLSGEALMGTQGYGIDPAIVNSIASDVAKVVAGGTELAIVVGGGNIFRGLKGSAAGMERATADYVGMLATVMNAITLQDGLERAGVPTRVQTAIAMQEVAEPYIRRKAMRHLEKGRVVVFGAGCGNPFFTTDTTAALRAAEINADVVFKATKVDGVYDKDPAKHADAVKHAHLTYQDVLSGELAVMDSTAIALCKDNNIPIVVFNLFEPGNIGRAVAGEPIGSRIGNPA
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_BOVIN
Sequence: MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPVPTA
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Has endonuclease activity and plays a role in repair of damaged DNA.  Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA.  Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS).  Has also been shown to bind with similar affinity to intact and damaged DNA.  Stimulates the N-glycosylase activity of the base excision protein OGG1.  Enhances the uracil excision activity of UNG1.  Also stimulates the cleavage of the phosphodiester backbone by APEX1.  When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage.  Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide.  Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes.  Represses its own translation by binding to its cognate mRNA.  Binds to and protects TP53/p53 from MDM2-mediated ubiquitination.  Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization.  Involved in induction of apoptosis through its role in activation of CASP8.  Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5.  Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.
What are the official names of this protein?
40S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Mitochondrion inner membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle. Note=In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis. Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide. Accumulates in the mitochondrion in response to increased ROS levels. Localizes to the spindle during mitosis. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: COQ7_ACIB3
Sequence: MRHYTGIDQLINSFDQALRSLVPGATAAQRQNPAETVEAKLGVEDARHVAGLMRVNHSGEVCAQALYHGQALTAKLPNVRREMQQAAIEEQDHLAWCEDRLKELNSHTSLLNPIWYGLSYGMGALAGIAGDKYSLGFVAETERQVSLHLQDHLNQLPAQDERSRKILEQMNEDELHHRHTALEAGGVELPYAVKITMTAISKLMTKTSYYL
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SPIB_HUMAN
Sequence: MLALEAAQLDGPHFSCLYPDGVFYDLDSCKHSSYPDSEGAPDSLWDWTVAPPVPATPYEAFDPAAAAFSHPQAAQLCYEPPTYSPAGNLELAPSLEAPGPGLPAYPTENFASQTLVPPAYAPYPSPVLSEEEDLPLDSPALEVSDSESDEALVAGPEGKGSEAGTRKKLRLYQFLLGLLTRGDMRECVWWVEPGAGVFQFSSKHKELLARRWGQQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPAVRRA
What is the function of this protein?
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer.  Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells.  These cells have the capacity to produce large amounts of interferon and block viral replication.  May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
What are the official names of this protein?
Transcription factor Spi-B.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: DEOB_CHRVO
Sequence: MKRAIILILDSLGIGAAADAPKFGDAGSNTLGHIAMEAAAGRADIGRSGPLKLPNLSRMGLGHACQLSSGYFPEGMDPAAPAAAYGYAREISSGKDTPSGHWEIAGVPVLFDWGYFSDHDNSFPQQLLDAIVDKAGLPGYLGNCHASGTEILDRLGEEHMKTGKPIFYTSADSVFQIACHEETYGLERLYELCKITRELLEPYNIGRVIARPFVGEGKGKFARTGNRKDLAVEPPAATVLKKLADAGGDVVSIGKIADIYAHVGITHKHKATGFDQLWDATLTAMDQHRDKPAIIMANFVDFDSSYGHRRNTAGYAAALEEFDARLPEVMAALGDDDILILSADHGCDPTWPGTDHTREHIPVLCYGKQVKAGPIGERATFADIGQSVAAHLGLPRMDYGTSFLD
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBS3_SOLLC
Sequence: MASSVMSSAAVATRGNGAQASMVAPFTGLKSTASFPVSRKQNLDITSIASNGGRVSCMQVWPPINMKKYETLSYLPDLSDEQLLSEIEYLLKNGWVPCLEFETEHGFVYRENHKSPGYYDGRYWTMWKLPMFGCTDATQVLAEVQEAKKAYPQAWVRIIGFDNVRQVQCISFIAYKPEGY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.  Involved in antiviral defenses (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic 3, RuBisCO small subunit 3, Ribulose bisphosphate carboxylase small chain 3A/3C, chloroplastic, RuBisCO small subunit 3A/3C.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast. SUBCELLULAR LOCATION: Cell junction, plasmodesma. Note=(Microbial infection) May be present in virus replication complexes (VRCs) of tobamovirus infected cells.
Protein: SERC_SHEDO
Sequence: MSRIYNFCAGPAMLPAAVMQKAQQELLDWNGLGVSVMEISHRSKEFIALAEQAEVNLRQLMNIPNHYHVLFMHGGGRSQFSNVVNNFLGDHGRALYLVSGQWSQSAVEEAQKLAGEAQIDALNIVTKADGLNQVTLPDLHSIKKDYRYVHYCTNETVDGIEIFDELDSPWPIVADLSSTIMSREIDVSRYGLIYAGAQKNIGPSGLSIVIVRDDMLKLASLPQSSVMDYRIAAENGSMFNTPPTFAWYLAAEVFNWLKGLGGVEVIAQVNQQKAQLLYACIDDNSFYRNGVAKQNRSQMNVTFQLADDSLDSRFLAEAERAGLVALKGHRIVGGMRASLYNAMPLEGVQALVTFMSEFATKHS
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDGC_NEIMF
Sequence: MWFKQISFYPLNKEKLPEADVLADKLAEAEFTHCQGLDWFSEGFTAPVSFSPELVFPADFTLRVALKKEEKVLPAGVIRDILEEKVAEIQNNEARNVGRKEKQELKEQITDDLLPRAFTRSSRTEAVFNTRHGYLLVNNAASAKAENILTKLREALGGLEASLPNTKQSPSSLMTGWLLQGHCEGGFELDSDCELKGTGDIVPVVKVSKQDLTADEVVQHVKNGKTVTQLGLVWREQIAFILTQDFTLKRIQYLDVLQEEAESNGDDAAGLAFASQILMAESVSTMLEELVSYLGGWQD
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: KRR1_DROME
Sequence: MSESEAEETKISTEPVDNAWSMKIPAFRQEDNPHGMVEESSFATLFPKYRERYLKEVWPLVEQCLAEHHLKAELDLMEGSMVVKTSRKTWDPYIIIKARDMIKLMARSVPFEQAKRVLQDDIGCDIIKIGNLVHKKEKFVKRRQRLIGPNGATLKSIELLTDCYVLVQGNTVSALGPYKGLQQVRDIVLETMNNVHPIYNIKALMIKRELMKDPRLANEDWSRFLPKFKNKNISKRKQPKVKKQKKEYTPFPPSQPESKVDKQLASGEYFLNQEQKQAKRNQERTEKQKEAAKRQDERRNKDFVPPTEESAASSRKKEDGSSSSKVDVKALKAKLIKANKKARSS
What is the function of this protein?
Required for 40S ribosome biogenesis.  Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.  Binds to RNA.  Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development.
What are the official names of this protein?
KRR1 small subunit processome component homolog, KRR-R motif-containing protein 1, Protein dribble.
What is the protein family that this protein belongs to?
Belongs to the KRR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Exogenous expression in embryos shows a predominant localization in nucleoplasm in some epidermal cells while most other cells show perinucleolar ring structure. In heat-shocked third instar larvae, localization varies among cells. In gut cells, some show localization in both nucleoplasm and nucleolus while in others localization is restricted to the center of the fibrillarin-positive part of the nucleolus, in the fibrillar center, where rRNA transcription occurs. On ectopic expression, a nuclear engrailed pattern is observed in embryonic epidermal cells.
Protein: RPOC_ECOLI
Sequence: MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSIKLSNVKSVVNSSGKLVITSRNTELKLIDEFGRTKESYKVPYGAVLAKGDGEQVAGGETVANWDPHTMPVITEVSGFVRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKIVDAQGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQESGGTKDITGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVISDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANRELEANGKVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAGEAPAAPQVTAEDASASLAELLNAGLGGSDNE
What is the function of this protein?
Part of the processive rRNA transcription and antitermination complex (rrnTAC).  The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNAP.  It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: COBT_SALHS
Sequence: MQTLHALLRDIPAPDAEAMARAQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGEKAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGGFDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIALAHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLPEGNANAT
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: GATB_FRAT1
Sequence: MNWEMVIGLEVHIQLSTKSKLFSTSATKYGQHQNTQAAFLDLGLPGTLPVVNKEAIRKAVIFGLAVDAKISKDSFFARKNYFYPDLSKGYQISQSTNPIVQEGRLEIETSKGLKTIRIERAHLEEDAGKSVHGYIAGETGLDYNRAGTPLLEIVTYPDFRSAEEVVAYLKKLHQLVKHLGICDGNMQEGSFRCDVNLSIRPQGQAKFGTRAELKNINSFRFIDKAIEYEYARQVSVLESGGEVVQETRLYDADANETRSMRAKEDAFDYRYFPDPDLLPLVITDEYIESIKKQMPLKSEEREAVYREHLAEQEVEFLLSNLEIADYYDKVAVVIGYKPAYNWITVDLISTLNRAEKEFSSDVVPAEILLEIIANVQKDIISQANAKKVIAEYIDAPSAIEAIIEKLGLKQVSDEGMIRELVQGIIAANPQQAADFKAGKTKLMSFFVGQAMKASKGKANPKQVNQIVQEELNK
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: MTRF_METAC
Sequence: MRMAEEYGKGVPMVLNPQMGAIDATVESIRYRAQLIARNQKLDSGVMSTGIIGFAAGFLFSLLMVIILPLMAGL
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit F, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit F.
What is the protein family that this protein belongs to?
Belongs to the MtrF family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CAPSD_HBVC1
Sequence: MDIDTYKEFGASVELLSFLPSDFFPSIRDLLDTAFALHREALESPEHCSPHHTALRQAIVCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSVGVWIRTPQAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSKSPRRRRSQSRESQC
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsids are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stuck in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg, p21.5.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus core antigen family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: PPME1_PONAB
Sequence: MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRSHGETKVKNPEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIGVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC
What is the function of this protein?
Demethylates proteins that have been reversibly carboxymethylated.  Demethylates PPP2CB (in vitro) and PPP2CA.  Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity).
What are the official names of this protein?
Protein phosphatase methylesterase 1, PME-1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: C13A1_CAEEL
Sequence: MGYFWFPWFSAIFVAVFSYYIWQWTFWRRRGVVGPMGFPVLGVFLNSLDNNFPFPLQCREWTKKFGKIYGFTEGTLKTLVISDPELVHEVFVTQYDNFYGRKRNPIQGDSEKEKRTNLFAAQGFRWKRLRAISSPTFSNSSLRKLYQTVEDSALELLRHIEKQSAGGKQIDMLKFYQEFTLDVIGRIAMGQTDSQMFKNPIMPIVSKLFQGNFAKLFLIGGIFPTFLVEIIRQILLKNLKVGSFRKINEITLDAIHNRIKQREEDQKNGIEIGEPADFIDLFLDAKAEDVEHFGENNGDFSKSTTYTNRQLTTEEIVGQCTVFLIAGFDTTALSLSYATYLLATHPEIQKKLQEEVNRECPNPEVTIDQLSKLKYMECVFKEALRLYPLGAFANSRRCMRNTKLGNMKVEVGTMIQVDTWTLHTDPNIWGDDAEDFKPERWQTPNSDQIYQKSGYIPFGLGPRQCIGMRLAYMEEKILLVHILRKFTFETGAKTEIPLKLIGRATTQPESVWMHLNPRN
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Putative cytochrome P450 CYP13A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: RPIA_STRP2
Sequence: MENLKKMAGIKAAEFVSDGMVVGLGTGSTAYYFVEEIGRRIKEEGLQITAVTTSSVTTKQAEGLNIPLKSIDQVDFVDVTVDGADEVDSQFNGIKGGGGALLMEKVVATPSKEYIWVVDESKLVEKLGAFKLPVEVVQYGAEQVFRHFERAGYKPSFREKDGQRFVTDMQNFIIDLALDVIENPIAFGQELDHVVGVVEHGLFNQMVDKVIVAGRDGVQISTSKKGK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.