PharMolix/UniProtQA huggingface dataset:
Protein: UBIE_PROMH
Sequence: MTQQSKETTDFGFQTVDKDEKQTMVAKVFHSVASKYDLMNDLMSFGIHRVWKRYTIEASGVRRNQRVLDLAGGTGDLTAKFSRLVGENGEVVLADINDSMLKMGREKLRDHGIVGNVSYVQANAEELPFPDDYFDCITISFGLRNVTDKAKALRSMFRVLKPGGRLLVLEFSKPVLDPLSKIYDAYSFHILPRIGQVIVNDADSYRYLTESIRMHPDQETLKGMMEEAGFDQVSYTNMTGGIVALHKGFKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: FMT_HUMAN
Sequence: MRVLVRRCWGPPLAHGARRGRPSPQWRALARLGWEDCRDSRVREKPPWRVLFFGTDQFAREALRALHAARENKEEELIDKLEVVTMPSPSPKGLPVKQYAVQSQLPVYEWPDVGSGEYDVGVVASFGRLLNEALILKFPYGILNVHPSCLPRWRGPAPVIHTVLHGDTVTGVTIMQIRPKRFDVGPILKQETVPVPPKSTAKELEAVLSRLGANMLISVLKNLPESLSNGRQQPMEGATYAPKISAGTSCIKWEEQTSEQIFRLYRAIGNIIPLQTLWMANTIKLLDLVEVNSSVLADPKLTGQALIPGSVIYHKQSQILLVYCKDGWIGVRSVMLKKSLTATDFYNGYLHPWYQKNSQAQPSQCRFQTLRLPTKKKQKKTVAMQQCIE
What is the function of this protein?
Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation.
What are the official names of this protein?
Methionyl-tRNA formyltransferase, mitochondrial, MtFMT.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: SYR_RHOE4
Sequence: MTPADLAELLRGTAASVLADRGLDVSVLPETLTVERPRNPEHGDYATNIAMQVAKKVGTNPRELAGWIAEALTAADGIESAEIAGPGFLNIRLDKDAQGAIVVSVLEAGSSYGSGDSLAGKKINLEFVSANPTGPIHLGGTRWAAVGDALGRILSAQGGLVTREYYFNDHGAQIDRFSRSLIAAAKGEPAPEDGYAGAYIADIAASVLKQRPDVMELPADEQQETFRAIGVELMFTHIKQTLHDFGVDFDVYFHENSLFESGAVEKAVESLKGSGNLFHEDGAWWLKSTDYGDDKDRVVIKSDGNAAYIAGDIAYFQNKRARGFDLCIYMLGADHHGYIGRLKAAAAAFGDDPDTVEVLIGQMVNLVKDGTAVKMSKRAGTVITLDDLVEAIGVDASRYVMIRSSVDSSIDIDLDLWTKTSSENPVYYVQYAHARLSAIARNAADLGLSADASNLALLTVEQEGDLIRTIGEYPRVVSSAANLREPHRIARYLEELAGAYHRFYGACRILPQGDEDATDVHRARLALCAATRQVLANGLELLGVTAPEQM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR15_OENPA
Sequence: MVKNAFISVISQEENRGSVEFQVVSFTNKIRRLTSHLEFHRKDFLSQRGLRKILGKRQRLLSYLSKKDKVRYTELISQLDIRELTTR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PAP_HHV11
Sequence: MTDSPGGVAPASPVEDASDASLGQPEEGAPCQVVLQGAELNGILQAFAPLRTSLLDSLLVMGDRGILIHNTIFGEQVFLPLEHSQFSRYRWRGPTAAFLSLVDQKRSLLSVFRANQYPDLRRVELAITGQAPFRTLVQRIWTTTSDGEAVELASETLMKRELTSFVVLVPQGTPDVQLRLTRPQLTKVLNATGADSATPTTFELGVNGKFSVFTTSTCVTFAAREEGVSSSTSTQVQILSNALTKAGQAAANAKTVYGENTHRTFSVVVDDCSMRAVLRRLQVGGGTLKFFLTTPVPSLCVTATGPNAVSAVFLLKPQKICLDWLGHSQGSPSAGSSASRASGSEPTDSQDSASDAVSHGDPEDLDGAARAGEAGALHACPMPSSTTRVTPTTKRGRSGGEDARADTALKKPKTGSPTAPPPADPVPLDTEDDSDAADGTAARPAAPDARSGSRYACYFRDLPTGEASPGAFSAFRGGPQTPYGFGFP
What is the function of this protein?
Plays an essential role in viral DNA replication by acting as the polymerase accessory subunit.  Associates with the viral polymerase to increase its processivity and forms high-affinity direct interactions with DNA.  Facilitates the origin-binding protein UL9 loading onto DNA thus increasing its ability to assemble into a functional complex capable of unwinding duplex DNA.
What are the official names of this protein?
DNA polymerase processivity factor, DNA-binding protein UL42, Polymerase accessory protein, PAP.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA polymerase processivity factor family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: APAH_BURP2
Sequence: MTNFSSSPPIAFGDLQGCHAAYRQLFDTLAPAADTPLWFAGDLVNRGPASLATLREIVALGERAIAVLGNHDLHLLAVAAGIRTLKPGDTIGEILDAPDADDLIEWVRHRPFAHFERGMLMVHAGLLPQWDAALALELADELQRALRAPNWRDTLRSLYGNDPNCWSPDLKHADRLRVAFNAFTRIRFCTPEGAMEFRANGGPAAAPAGYLPWFDAPGRKTADVTVVFGHWAALGLMLRENLVALDSGCVWGNRLSAVRLADDPAARVVTQVACERCGAADE
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: KV3AG_MOUSE
Sequence: DIVLTQSPASLAVSLGQRATISCKASQSLDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCHQSEDPWTFGSGTKLEIK
What are the official names of this protein?
Ig kappa chain V-III region PC 7210.
Protein: AVR4_CHICK
Sequence: MVHTTSPLLLLLLLSLALVAPSLSARKCSLTGKWTNNLGSIMTIRAVNSRGEFTGTYLTAVADNPGNITLSPLLGIQHKRASQPTFGFTVHWNFSESTTVFTGQCFIDRNGKEVLKTMWLLRSSVNDISYDWKATRVGYNNFTRLCTVEE
What are the official names of this protein?
Avidin-related protein 4/5.
What is the protein family that this protein belongs to?
Belongs to the avidin/streptavidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FAPR_STAAS
Sequence: MKLKKDKRREAIRQQIDSNPFITDHELSDLFQVSIQTIRLDRTYLNIPELRKRIKLVAEKNYDQISSIEEQEFIGDLIQVNPNVKAQSILDITSDSVFHKTGIARGHVLFAQANSLCVALIKQPTVLTHESSIQFIEKVKLNDTVRAEARVVNQTAKHYYVEVKSYVKHTLVFKGNFKMFYDKRG
What is the function of this protein?
Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.
What are the official names of this protein?
Transcription factor FapR, Fatty acid and phospholipid biosynthesis regulator.
What is the protein family that this protein belongs to?
Belongs to the FapR family.
Protein: IF4G1_HUMAN
Sequence: MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
What is the function of this protein?
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.  As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139).
What are the official names of this protein?
Eukaryotic translation initiation factor 4 gamma 1, eIF-4-gamma 1, eIF-4G 1, eIF-4G1, p220.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4G family.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule.
Protein: XKR8_PANTR
Sequence: MPWSSRGALLRDLVLGVLGTAAFLLDLGTDLWAAVQYALGGRYLWAALVLALLGLASVALQLFSWLWLRADPAGLHGSQPPRRCLALLHLLQLGYLYRCVQELRQGLLVWQQEEPSEFDLAYADFLALDISMLRLFETFLETAPQLTLVLAIMLQSGRAEYYQWVGICTSFLGISWALLDYHRALRTCLPSRPLLGLGSSVIYFLWNLLLLWPRVLAVALFSALFPSYVALHFLGLWLVLLLWVWLQGTDFMPDPSSEWLYQVTVATILYFSWFNVAEGRTRGRAIIHFAFLLSDSILLVATWVTHSSWLPSGIPLQLWLPVGCGCFFLGLALRLVYYHWLHPSCCWKPDPDQVDGARSLLSPEGYQLPQNRRMTHLAQNFFPKAKDEAALPVKG
What is the function of this protein?
Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface.  Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.  Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (By similarity).  Has no effect on calcium-induced exposure of phosphatidylserine (By similarity).  Promotes myoblast differentiation and survival (By similarity).
What are the official names of this protein?
XK-related protein 8.
What is the protein family that this protein belongs to?
Belongs to the XK family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
Protein: TAD2B_XENLA
Sequence: MADLSKKYCVYCLADVTSLRLRCTECQDIELCTDCFSAGAEIGNHRRWHGYQLVDGGRFTLWGPEAEGGWTSREEQLLLDAIEQFGFGNWEDMAAHVGASRTPTEVMEHYVTMYIHGNLGKACIPDSIPNRVTDHTCPTGGPLSPSLTTPLPTLDLTVADQQQLGYMPLRDDYEIEFDQEAETLISGLSVNYDDDDVEVELKEAYVDMYVRKLKERQRRKSLARDYNLVPAFLGKDKKEKEKPAKRKISKEEKELRLKLRPLYQFMSNKEIEDCFENMHKERMLRAKIRELQRYRRNGITKTEESAEYEAARHKREKRKENKNIANSKRGREDGKESEFAAIENLAGFELLSDREKVLCSSLNLSPTRYLTVKTIIIKDHLQKRQGIPSKSRLPSYLDKVLKKRILNFLTESGWISRDAS
What is the function of this protein?
Transcriptional coactivator.
What are the official names of this protein?
Transcriptional adapter 2-beta.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS11_BUCAT
Sequence: MVKNSTSIRTRKRVKKQILDGIAHIHASFNNTIVTITDRQGNALGWATSGGSGFRGSRKSTPFAAQVAAERCAEIVKDYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: HBA3_GORGO
Sequence: VLSPADKTNVKAAWGKVGAHAGDYGAEALERMFLSFPTTKTYFPHFDLSHGSAZVKGHGKKVAKALTBAVZHLDDMPNALSALSBLHAHKLRVBPVBFKLLNHCLLVTLAABFPSZFTPAVHASVDKFLASVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-3, Alpha-3-globin, Hemoglobin alpha-2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: NADE_SHIBS
Sequence: MTLQQQIIKALGAKPQINAEEEIRRSVDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLCQMAINELRQETGNESLQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTDINPLYRLNKRQGKQLLAALACPEHLYKKAPTADLEDDRPSLPDEVALGVTYDNIDDYLEGKNVPQQVARTIENWYLKTEHKRRPPITVFDDFWKK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: THIM_CERS1
Sequence: MDGCGTYLDTMRREAPLVQCITNFVAMNVVANVLLAAGASPAMVHDAEESGEFAAIAQALTINMGTPSPRWVEGMEAAARGAAAAGRPWVLDPVAVGATAFRRGLGARLLALKPTVIRGNASEILALAGAETRGKGADSADPVAAAEAAAQRLAESSGAVVAVTGPVDFVTDGRRGIRCANGHPLMPRVTALGCSLTGIVGAFAAIRPPFEATAAALAFFGLAGEEAAKTATGPGSFQVAFLDALHALSPEALDRGARLEAA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: F16PA_HAEIE
Sequence: MKTLSEFIVERQAEYPNAKGELSGILSSIRLLAKIIHRDINKAGLTNILGQSGIENVQGESQMKLDLFAHNTMKAALMAREEVAGFASEEEESFIAFDTERGRNAKYIILTDPLDGSSNIDVNVSVGTIFSIYRRVSPIGSPVTLEDFMQPGNKQVAAGYIVYGSSTMLVYTTGHGVNGFTYDPSIGTFCLSHENMQMPKEGKIYSINEGQYLKFPQGVKKYIKYCQEEDKATHRPYVSRYIGSLVADFHRNLLKGGIYIYPSATNYPNGKLRLLYEGNPIAFLAEQAGGVATDGYRRILDIEPTALHERVPLFVGSEDMVKKAQEMMEEFKE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_BACC0
Sequence: METTVRKQKKNLETKKPSIYSLQLHEMQDWLKEQGEPKFRAGQIFDWLYKKRVKNYEDMSNLSKGLREKLSNSFDITTLNTLVKQTSSDGTIKFLFQLYDGYSIETVLMRHEYGNSICVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVEVQRALDESEERVSSLVVMGIGEPFDNYDNLMGFLRIINHEKGLHIGARHMTVSTSGIIPKIYKFAEEDLQINFAISLHAPNSELRSKLMPINRAYKLPDLMEAIKYYVNRTGRRITFEYGLFGGENDQVEHAEELAALLKGVKCHVNLIPVNYVPERDYVRTPREQIFLFEKTLKDRGVNVTIRREQGHDIDAACGQLRAKERKEETR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_RICBR
Sequence: MMLIIGLGNPGKEYEHTRHNIGFIALENIAKQYETSFSVKKKFHCEIAESTNNGQKLIFVKPTTYMNLSGKSVIAVKTYYNIPLEKIFVIHDDIDLELGKIKFKTGGGNGGHNGLKSIDGIIGNNYHRIRIGVGRPQNSQDVADYVLNNFSKTEYVIAEQAIDKITDNFNLILENKLEEFKSKMV
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_WOLPM
Sequence: MAERANDIRPGQVLEHNGGLFLVVGIMHTQPGKGGAYIQAEMKNIKTGAKHYERFRSDATIRRAILDEEEYVYLFTEGNIVNLMHPSNYEQITINLDLLGEKKIYLQDNMKIKVVAYQDKIISAHVPDYVTLAVKETESVIKGQTATASYKPAILENGMRVNVPQFIKEEDKIVVYTPGDSYYERVKE
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASB5_BOVIN
Sequence: MSMVEENRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYGVTQGRGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTIDHVTPLHEACLGDHVACARTLLQAGANVNAITIDGVTPLFNACSQGSTSCTELLLEYGAKPQLESCLPSPTHEAASKGHHECLEILISWGVDVDQDIPHLGTPLYVACMSQQFHCVRKLLYAGADVQKGKYWDTPLHAAAQQSCTEIVNLLLEFGADINAKNTDLLRPVDVATSNSLVERLLLQHEATPSSLCQLCRLCIRNYIGRPRLHLIPQLQLPTLLQNFLQYR
What is the function of this protein?
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  May play a role in the initiation of arteriogenesis (By similarity).
What are the official names of this protein?
Ankyrin repeat and SOCS box protein 5, ASB-5.
What is the protein family that this protein belongs to?
Belongs to the ankyrin SOCS box (ASB) family.
Protein: FOXF2_HUMAN
Sequence: MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM
What is the function of this protein?
Probable transcription activator for a number of lung-specific genes (PubMed:8626802).  Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (PubMed:29374064).
What are the official names of this protein?
Forkhead box protein F2, Forkhead-related activator 2, FREAC-2, Forkhead-related protein FKHL6, Forkhead-related transcription factor 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: ALGL_PSEA7
Sequence: MKTSHLIRITLPGALAAALLASQVSQAADLVPPPGYYAAVGERKGSAGSCPSVPPPYTGSLVFTSKYEGSDSARATLNAKAEKAFRSQIKDITDMERGATKLVTQYMRSGRDGDLVCALNWMSAWARAGALQSDDFNHTGKSMRKWALGSLSGAYMRLKFSSSRPLSAHAGQSREIEDWFARLGTQVVRDWSNLPLKKINNHSYWAAWSVMSTAVVTNRRDLFDWAVSEFKVAANQVDEQGFLPNELKRRQRALAYHNYALPPLAMIAAFAQVNGVDLRQENHGALQRLAERVMNGVDDEETFEEKTGEDQDMTDLKVDNKYAWLEPYCALYRCAPKMLEAKKDREPFNSFRLGGEVTRVFSREGGS
What is the function of this protein?
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism.  May serve to degrade mislocalized alginate that is trapped in the periplasmic space.
What are the official names of this protein?
Alginate lyase, Poly(beta-D-mannuronate) lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 5 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SCNNB_RABIT
Sequence: MHVKKYLLKCLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIIREGPKKKAMWFLITLLFASLVCWQWGVFIKTYLSWEVSVSLSMGFKAMDFPAVTICNASPFRYSKVRHLLKDLDELMEAVLARILAPESSQANATAAMNLSMWNYTPLVLIDERDPHHPVVLDLFANDPTGSASSSPGPRGACNAQGCKVAMRLCSLNGTSCTFRNFSSATQAVTEWYALQATNIFSQVPQRELVELGYSAERLILACLFGAEPCSYRNFTSIFYPDYGNCYVFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIREEGVDAMSGTETSIGVLVDKLQRKGEPYSPCTVNGSDVPVQNLYGSYNTTYSIQACLHSCFQTQMIASCQCGHYLYPLPRGQEYCNSRDFPDWAPCYLALRMSEAERETCIRMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNVTLSRKGVVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFAEIIIDFVWITIIKLVALAKGLRQRQAQARYAGPPPTVAELVEAHTNFGFQPDVGHRSPDAEAYPDEQALPIPGTPPPNYDSLRLQPLDVVESDSEGDAV
What is the function of this protein?
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride.  Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells.  Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.  Controls the reabsorption of sodium in kidney, colon, lung and sweat glands.  Also plays a role in taste perception.
What are the official names of this protein?
Amiloride-sensitive sodium channel subunit beta, Beta-NaCH, Epithelial Na(+) channel subunit beta, Beta-ENaC, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB.
What is the protein family that this protein belongs to?
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=Apical membrane of epithelial cells.
Protein: YIM1_YEAS7
Sequence: MPDEIVTNKSVTYVNNTTPVTITSSELDLRSCYQDDEVVIEVHAAALNPIDFITHQLCNSYIFGKYPKTYSRDYSGVIIKAGKDVDNRWKVGDKVNGMYSHIYGERGTLTHYLILNPAKDVPITHMVEVPKDENDPYDDFVYAAAWPLTFGTAFSTLYDFKKDWTSDSKVLVIGASTSVSYAFVHIAKNYFNIGTVVGICSKNSIERNKKLGYDYLVPYDEGSIVENVKKLKQSVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNNKADYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYPPNNFIEVGNEMIKKGTYKPPIDSVYEFDQYKEAIDRLISNRAKGKVVVKMK
What are the official names of this protein?
Protein YIM1.
What is the protein family that this protein belongs to?
Belongs to the YIM1 family.
What are the subcellular locations of this protein?
Lipid droplet. Mitochondrion.
Protein: EI2BG_DICDI
Sequence: MTQTQFQVVILATDKASGNSKLEPIDATIPHSLLPIANRPLISYQLEFLEKAGFETKSEPVIIVVNETSQEKIKQYVSEIYKGKIEVEFFVLKDQLATCEILYRIRDKIRLEYFMVLNANLVLEDTFIRQMADLHRKEESSLTVLLKPPTPKVEQKGKGATETSTKQDKLFTDYIALEEKSQKIVMMEPATEVEEDLNFNKSLLKYFPNVTIYTNLQDTQLYIFSRWVLDLIIEDQKEKYPLFFDIKKHLIPYLLSCQIPNIKRKRALPASAFNQNQTLSQTMSSTTSPFDQFSELNAQKNKTIKCFAHLLKKEGYCMNVNTIKNYQQINRDIAKGDLQYLPNEPKSEKNFFIDPTANVTITQVGPQCVIGTSTTLGAKCSVKFSIIGKHCKIGDGVRIENSIIMDHVIIEDRCVINSSIICNDVYIKSGSSTVGQYLTK
What is the function of this protein?
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
What are the official names of this protein?
Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B gamma/epsilon subunits family.
Protein: RUVA_LEUCK
Sequence: MYEYINGLITNIYPAYLVIADRSGVGYKLFVANPYRFEQNVESHVYVEQIVRENEMTLYGFIDENEKYLFNKLLNVSGIGPKSALAILASDDAAGLVTAVANDDASYLTQFPGVGKKTAQQIVLDLKGKLDDLALSAGMTVETVPTTDNQALADALAALESLGYSAKDVAKLQTVLANQKDTTDGYIRSALKFLVK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RRAAH_ALKEH
Sequence: MSVPTTDLCDDFADELRVMNPMFRDFGGRVRFHGPVTTVKLFEDNSAVREALSEPGEGRVLVVDGGGSMRCALLGDNLAALGQKNGWAGVVVYGCVRDSAELATIDLGVKALNVHPLKSVKKGIGERDVTVTFAGITIQAGDWLYADEDGIVVARNSLVQA
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.