PharMolix/UniProtQA huggingface dataset:
Protein: GLPG_SHISS
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLENPADPRYLAASWQAGHTGSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPALKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IFNL3_HUMAN
Sequence: MTGDCMPVLVLMAAVLTVTGAVPVARLRGALPDARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTLKVLEATADTDPALGDVLDQPLHTLHHILSQLRACIQPQPTAGPRTRGRLHHWLHRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV
What is the function of this protein?
Cytokine with antiviral, antitumour and immunomodulatory activities.  Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.  Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state.  Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1.  Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense.  Plays a significant role in the antiviral immune defense in the intestinal epithelium.  Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
What are the official names of this protein?
Interferon lambda-3, IFN-lambda-3, Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C.
What is the protein family that this protein belongs to?
Belongs to the lambda interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: PURA_CROS5
Sequence: MANVIVIGAQWGDEGKGKITDLLSRSADVVVRPQGGVNAGHTIVVQGQTFKLHLIPSGILYPETECIIGSGTVIDPKVLLEELGQLKSLNVATDNLFISQTAHITMPYHRLFDQASEQRRGEKKIGTTGRGIGPTYADKSERTGIRVVDLMNPDELQEKLEWTINYKNVILEKLYNLDPLDPKVVIEEYINYADQLRPYVIDSSLKIYEAIQERKNILFEGAQGTLLDLDHGTYPYVTSSNPIAGGACVGSGIGPTVIDRVIGVAKAYTTRVGEGPFPTELHGDIGQQLCDRGAEFGTTTGRRRRCGWFDAVIGRYAVRVNGLDCLAITKLDVLDELAEIKVCTAYELDGQTCHHFPSNASEFARCTPIYETLPGWQQSTENCRSLEDLPKEALDYLKFLAELMEVSIAIVSLGASRDQTIIVEDPIHGPKRALLDENGDPVTTHE
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STR3_YEAST
Sequence: MPIKRLDTVVVNTGSQNDQHSASVPPVYLSTTFKVDLNNEDAQNYDYSRSGNPTRSVLQHQIGKLYRVPQENVLAVSSGMTALDVILRGLVLLNGTDNHTPTIIAGDDLYGGTQRLLNFFKQQSHAVSVHVDTSDFEKFKTVFQSLDKVDCVLLESPTNPLCKVVDIPRILRFVKCISPDTTVVVDNTMMSGLNCNPLQLNPGCDVVYESATKYLNGHHDLMGGVIISKTPEIASKLYFVINSTGAGLSPMDSWLLVRGLKTLGVRLYQQQRNAMILAHWLENSCGFKPTRTNKATKTRFVGLRSNPDFKLHKSFNNGPGAVLSFETGSFEHSKRLVSSKKLSIWAVTVSFGCVNSLLSMPCKMSHASIDPELRKERDFPEDLVRLCCGIENIVDLKKDLLAAMVDADIIEVRENGKYLFNKLNKNLAVNTTIDDLHKPLSIYEEFYNQDLIRKDSELNIKSSKL
What are the official names of this protein?
Cystathionine beta-lyase, CBL, Beta-cystathionase, Cysteine lyase, Cysteine-S-conjugate beta-lyase, Sulfur transfer protein 3.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SG111_DROGR
Sequence: MANSNTNQLHPLGATTSQTFTTALNHTAASTIAINFRELIKEPKELDEASNYLYQALLDDVVAGIFIETHHLRKTGNLAALDGVGEENLESAFHICEMPNLDIFGISTAKKQMDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGSSASTSSTSTYLQSGGNTGGTDDEDDVDWSSDKRKKKSTQSSRNNGSKKNNGKTF
What is the function of this protein?
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Binds independently on SAGA to promoters in an RNA-dependent manner.  Binds to mRNA and is essential for total mRNA export from the nucleus.  Required to counteract heterochromatin silencing.  Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe.  Required for expression of ecdysone-induced genes such as br/broad.
What are the official names of this protein?
SAGA-associated factor 11 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the SGF11 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Localizes to nuclear periphery, in contact with the nuclear pore complex (NPC).
Protein: RAB14_RAT
Sequence: MATTPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
What is the function of this protein?
Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity).  Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development.  Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.  May act by modulating the kinesin KIF16B-cargo association to endosomes.
What are the official names of this protein?
Ras-related protein Rab-14.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or Mycobacterium.
Protein: Y812_STAAC
Sequence: MKIAVMTDSTSYLSQDLIDKYNIQIAPLSVTFDDGKNFTESNEIAIEEFYNKMASSQTIPTTSQPAIGEWITKYEMLRDQGYTDIIVICLSSGISGSYQSSYQAGEMVEGVNVHAFDSKLAAMIEGCYVLRAIEMVEEGYEPQQIIDDLTNMREHTGAYLIVDDLKNLQKSGRITGAQAWVGTLLKMKPVLKFEDGKIIPEEKVRTKKRAIQTLEKKVLDIVKDFEEVTLFVINGDHFEDGQALYKKLQDDCPSAYQVAYSEFGPVVAAHLGSGGLGLGYVGRKIRLT
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein SACOL0812.
Protein: GNAI2_CANLF
Sequence: MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFDDPSRADDARQLFALSCTAEEQGVLPEDLSCVIRRLWADNGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYEEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.  May play a role in cell division (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-2, Adenylate cyclase-inhibiting G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody (By similarity).
Protein: THIM_VIBPA
Sequence: MLIEQITQALTAVRQQKPLVVNITNYVVMNNTANALLAIGASPIMAHSKQEMAEMMSFAGALVINIGTLDSVWTPRMSYAVEQANSNGKIVVLDPVGCGASSLRTETSREIARLANKLIIRGNASEIIALAGEQAQSKGVDALDSSDAALGAAHFLVKEYGASVVISGETDYIVTKEQTVQLNNGHEMMPYVTGMGCTLTALTGAFAAIGDETGLAAAAVLGVVGEIAAEQARGPGSLQMHLLDELYQLDEETLATRLKLQVR
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: TPIS_HERAR
Sequence: MRRKLVAGNWKMNGSLAANALLLAEIKAEFGNPACDVAVCVPAPYLAQCLSLLSDSTIALGAQDVSSHDSGAYTGEVSTAMLLEFACRYVIVGHSERRAYFGETNELVAQKTVRALSAGLMPIVCVGETLEQREAGQTDEVVGRQIDAVLSSIAENDLAKIVVAYEPVWAIGTGKTATPEMAQEVHVMLRRRLHAKNAQAATEVRILYGGSMKPDNAKELLAMPDIDGGLIGGAALKAADFLAIIRAA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERA_ECO57
Sequence: MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGVLTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY
What is the function of this protein?
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway.  Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
What are the official names of this protein?
D-3-phosphoglycerate dehydrogenase, PGDH, 2-oxoglutarate reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: SYC_BRUO2
Sequence: MPDTAPQLRLYNTLTRTKEAFAPIDAKNVRMYVCGPTVYDFAHIGNARPVIVFDVLFRLLRHVYGAQHVTYARNITDVDDKINARAARDYPDLPFNEAIRKVTESTNAQFQADVTALGNLQPTVQPRATEHMDEMRAMIDRLVQRGVAYVAQDHVLFSPSAMDARKGPRYGALARRSLDEMLAGARVDVASYKRDEMDFVLWKPSKKGEPGWPSPAGIETLGRPGWHIECSAMSMAKLLEPFGGGLKCDDPERNQFDIHGGGIDLVFPHHENEIAQSCCALGTERMANIWMHNGFLQVEGQKMSKSLGNFITIRDVLNDGLPQLGEWGDNTVRDRWAGLAARLSMLQTHYREPINWTAQRLAESADELHRWYGLLRDEGFGAPEKLSHASAVAAALCDDLNSWAAITALRQAFKVRDVAALGEGMALMGLLDPYFVTASDVPIFARADVDASAIAARIAERLNFINAKNWAEADRIRDELLQEGVQLKDSKDSATGERITTWDVVG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_SACD2
Sequence: MAIERTLSIVKPDAVEKNIIGKVISRFEKAGLKIVAAKMMHLTEEKARGFYAEHEGRPFFAGLVEFMTSGPVVVQVLEGENAIALNRELMGATNPAEAAEGTLRKDFADSVGRNAVYGSDSPASAEREINYFFDASEICPR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K2M3_SHEEP
Sequence: SCRSYRISPGYSVTRTFSSCSAVAPKTGSRCCISAAPYRGVSCYRGLTGFGSRSVSALGSCGPRIAVSGFRAGSCGRSFGYRSGGVGGLSPSCITTVSVNESLLTPLNLEIDPNAQCVKHQEKEQIKNLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFNGYIETLRREAEHVEADSGRLASELDHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESNFLKRLYDEEIQILNAHISDTSVIVKMDNSRDLNMDCVVAEIKAQYDDIASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRVIQRLTAEIENAKCQRTKLEAAVAEAEQQGEAALNDARSKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSRGGVACGGLTYSSTAGRQIASGPVATGGSITVLAPDSCQPRASSFSCGSSRSVRFA
What is the function of this protein?
Wool microfibrillar keratin.
What are the official names of this protein?
Keratin, type II microfibrillar, component 5.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: KUP_YERPE
Sequence: MSTEHKQYLSAVTLAAIGVVYGDIGTSPLYTLRECFSGHYGFDVRPDVVFGFLSLIFWMLILVVSVKYLTYVMRADNAGEGGILTLMSLAGRNTSSRATSILVVLGLIGGSFFYGEVVITPAISVMSAIEGLEIAAPALDPYIVPCSIAVLTLLFVIQKHGTGSVGKLFAPVMLVWFLTLALLGLRSIIANPEVLAALNPKWAISFFVEYKSVSFFALGAVVLAITGVEALYADMGHFGKFPIRLAWFTVVLPSLVLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLILATLATVIASQAVISGVFSLTRQAVRLGYLPPMRIIHTSEMESGQIYIPVINWTLYLAVVLVIIGFERSSNLAAAYGIAVTGTMVITSILFCTVAWKNWHWNRFLVVFLLMVLLIIDIPMFSANVLKLFSGGWLPLSLGLVMFIIMTTWKSERFSLLRRMHEHSNSLEAMIASLEKSPPVRVPGTAVYMSRAMNVIPFALLHNLKHNKVLHERVVLLTMRTDDVPYVHNVERVTIEQLSPTFWRVVARYGWRETPNVAEIFHRCGLEGLSCQMMETSFFMSHESLILTKRPWHLFLRGKLFIALSRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURD_GEOUR
Sequence: MELLNKKILVVGLARTGVAVARFLAARGARVTVTDMKDEAALAPLMEQLADLDIDYELGRHERHSFLMADLVVVSPGVPMDIKPLLLAKAQRRTVISEIELAARFLTAPLVAITGTNGKTTTTTLTGEIFAACGFKTFVGGNIGNPLIELVTSGEAVDRVVVELSSFQLEGIIDFRPQVAVLLNITEDHLDRYATYQEYIDAKLRIFENQTSADYAVLNMDDPLVAAYAGKMKARVVPTSQRQELAQGIFYRNGSIVYRWEGREELFATASFRLKGVHNIDNIMAALASTLLMGCDAGQALAALEAFAGLPHRMEFVREVNGVAWYEDSKGTNVGSVVKSLESFDSGITLIAGGKDKGGEYTPLAGLVKERVGHLILIGEAKERMCNALGSLTDTHLADTLEDAVALAHRLTSPGGVVLFSPACSSFDMFKNYEERGECFKSLVRSLDDGAGR
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTW1_YEAST
Sequence: MSAPTMRSTSILTEHLGYPPISLVDDIINAVNEIMYKCTAAMEKYLLSKSKIGEEDYGEEIKSGVAKLESLLENSVDKNFDKLELYVLRNVLRIPEEYLDANVFRLENQKDLVIVDENELKKSEEKLREKVNDVELAFKKNEMLLKRVTKVKRLLFTIRGFKQKLNELLKCKDDVQLQKILESLKPIDDTMTLLTDSLRKLYVDSESTSSTEEVEALLQRLKTNGKQNNKDFRTRYIDIRTNNVLRKLGLLGDKEDEKQSAKPDARTQAGDIVSIDIEEPQLDLLDDVL
What is the function of this protein?
Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity.  MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.
What are the official names of this protein?
Kinetochore-associated protein MTW1, Mis12-like protein.
What is the protein family that this protein belongs to?
Belongs to the mis12 family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the kinetochore.
Protein: SECG_PICTO
Sequence: MPKNNTNENFQSGAGLIRYFNEEEIKGPALDPKLIIYIGIAMAVIVELAKIFWPV
What is the function of this protein?
Involved in protein export.  The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
What are the official names of this protein?
Preprotein translocase subunit SecG, Protein transport protein Sec61 subunit beta homolog.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ENY2_MOUSE
Sequence: MVVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes.  The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B.  The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity).
What are the official names of this protein?
Transcription and mRNA export factor ENY2, Enhancer of yellow 2 transcription factor homolog.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: IF4B1_ARATH
Sequence: MSKAWGGIGIGAWADEAERADEEQAAEATAATADTQSFPSLREAAAATATSGKSRKMKKMSLSEFTTGAYTAPGGRNSVGLTQQEILQLPTGPRQRSEEEMQPGRLGGGFSSYGGRSGGRIGRDRDDSDGSWSGGGGGGGRRPYGGGFDDDRRGNQSRVSDFPQPSRADEVDDWGKEKKPLPSFDQGRQGRYSGDGGGFGGGGSGFGGGGGGGGGGLSRADDVDNWGAGKRQAPVRSSTFGSSFGDSGQEERRRLVLEPRKVESGGSETPPVVEKTSKPNPFGAARPREDVLAEKGLDWKKIDSEIEAKKGSSQTSRPTSAHSSRPSSAQSNRSESSGLNNVVKPRPKVNPFGDAKPREVLLEEQGKDWRKMDLELEHRRVDRPETEEEKMLKEEIEELRKKLEKESVAPEIKESDQEPGSNNNHNDLPEIIRGKEKDLEILTRELDDKVRFRQKPVERPGSGAGRTGTYSERTHSRAGSIDETRSFESTERPRSRGAVDAWVRPANEQRRNFQGTKERGFFSNRSSSREGW
What is the function of this protein?
Promotes the eIF4F and eIF4A RNA-dependent ATP-hydrolysis activity with different efficiency depending on mRNAs, thus providing mRNA discrimination during initiation of translation.
What are the official names of this protein?
Eukaryotic translation initiation factor 4B1, AtTif4B1, eIF4B1.
What is the protein family that this protein belongs to?
Belongs to the eIF-4 subunit B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y5025_DICDI
Sequence: MKLINICIFIFAIICIESTFGFYTDNSNVINLTKKNFQQQVLNSQQNWMVEFYAPWCGHCKSLKPEYEKVSNNLKGLVKIGAINCDEEKELCGQYQIQGFPTLKFFSTNPKTGKKGQPEDYQGARSASEIAKFSLAKLPSNHIQKVSQDNINKFLTGTSDAKALLFTDKPKTTDLYKALSVDFFKTLTLGEARNLNKETLEKFNIDKFPTLLVFTNDDGETFTKFDGKLTHSTIYKFLEPFSKKSNNDNNNNNNNNNNEESTKTTTTEKDPASEKFIEIKDEKSFEKSCSTGLCIVALFDQSSIDDKELNEKYLELLNTVSQNFIGRMKFVWVDVSVHDKIVPQFDLSGTPNIFVINNSKKRYTPFMGSFSDESLNSFFKSVLSGLKKAIPFTDSPKFNSQQKKQKDEL
What are the official names of this protein?
Putative protein disulfide-isomerase DDB_G0275025.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RL5_LISMF
Sequence: MNRLKDQYLKEIVPALMSKFNYDSVMEVPKIDKIVINTGVGDATANAKVLDSAVEELALITGQKPVITKAKNSIAGFRLREGMPIGAKVTLRGERMYDFLDKLVTVSLPRVRDFRGVSKKAFDGRGNYTLGVREQLIFPEIDYDQVSKVRGMDVVIVTTAKSDEESHELLTQLGMPFQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ACPS_WOLSU
Sequence: MIGIDLVSIERIEAFIAKHGQRGLERFLLPEEILLANKPETIAGFWAAKEACSKALGTGIGAEVGFHDIRLFKNPKGAPLLELSPRVKDRFEIDSCALSITHDKGFAIAVVAMEKRRA
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHAP_BACSU
Sequence: MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISLFQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLDGMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLYAPVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVMEILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLTDVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMFGLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGARIYKGGVLIYGNSSAFKAIKQALRLAKN
What are the official names of this protein?
Uncharacterized protein YhaP.
What is the protein family that this protein belongs to?
To M.jannaschii MJ1024.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ORC4_PONAB
Sequence: MSSRKSKNNSLIHTECLSQVQRILRERFCHQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVVFILDEFDLFAHHKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLIEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSSLSWL
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent.  The specific DNA sequences that define origins of replication have not been identified yet.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.  Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).
What are the official names of this protein?
Origin recognition complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the ORC4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSD_RHOOB
Sequence: MARKPTPPGTPQPTSVGHIVDLVRGAVPPLHPAGLPFVLAPLGVAVLGRNRKWVRRGALTSAAACAAFFRHPHRVPPNRVGVAVAPADGEVALVDSAVPPSELDMGTEPLPRVSIFLSVLDVHVQRSPVGGEVTKVVHRSGQFLSADLADASEVNERNSMLLHTAEGHDVAVIQIAGLLARRIVCDAKVGDTLPIGDTYGLIRFGSRVDTYFPAGTTLLAERGQRTIGAETVIAQLP
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.