PharMolix/UniProtQA huggingface dataset:
Protein: IF2_STRZT
Sequence: MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAAKIAASFKPAAAPKVEAKPAAPKVSAEKKAEKSEPAKPAVAKEEAKPAEPVAPKTEKVAAKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNRRFNDQAKKQQGQQKRRNERRQQEDKRSNQAAPRIDFKARAAALKAEQNAEYARSSEERFKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKKQARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTPKPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGETIELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTAWGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAVATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGDHFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADVQGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQARQQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIGGFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDGYNDIKMDDVIEAYVMEEIKR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCAF_BPHC1
Sequence: MNKSKLKTDFICIATSGYTVDGRQITAQELHEMAETYDPEHYTANLWPEHRRWFNMGQVIELKAEENEKGETQLFAIIAPNKELIEYNRAGQYLFTSIEITPNFRNSGKAYLSGLGVTDSPASVGTTELKFFNAEQKGSVCGEFIKVDFSAKEDVEEEKALRTLANVFKKLFSILRPNGKNEPNPNNNNHKEDHAMNDKQFAQLIEAVKGLDAKIDNHFSAKVETKEPENKPEEKKDEQPQSVTAEQFNQLLITVQALDKKFNELSQEQTTVPSGVPTVEKENVYSLNGYNIDLSKGF
What is the function of this protein?
Scaffolding protein and protease involved in the icosahedric procapsid assembly.  Coassembles with the capsid proteins to form the procapsid, in which the scaffolding protein is found within the external shell of icosahedrally arranged capsid protein subunits.  In a subsequent step the scaffolding protein molecules are cleaved by the viral protease activity.
What are the official names of this protein?
Capsid assembly scaffolding protein, Gene product 17, Gp17, Head morphogenesis protein, Scaffold protein.
What is the protein family that this protein belongs to?
Belongs to the P2likevirus scaffolding protein family.
Protein: RL4_MYCPA
Sequence: MALKLDVKAPGGKVEGSIELPAELFDAPANIALMHQVVTAQRAAARQGTHSTKTRGDVSGGGRKPYRQKGTGRARQGSTRAPQFTGGGVVHGPKPRDYSQRTPKKMIAAALRGALSDRARNGRIHAITELVSGQTPSTKSAKAFLGALTERKQVLVVIGRSDEAGAKSVRNLPGVHILAPDQLNTYDVLRADDVVFSVEALRAYIAANTGTPEEVSA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: VATF_THET2
Sequence: MAVIADPETAQGFRLAGLEGYGASSAEEAQSLLETLVERGGYALVAVDEALLSDPERAVERLMRGRDLPVLLPIAGLKEAFQGHDVEGYMRELVRKTIGFDIKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit F, V-ATPase subunit F.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase F subunit family.
Protein: MIAA_YERPN
Sequence: MNDIENLDRPPAIFIMGPTASGKTALSIALRQRLPVELVSVDSALIYRGMDIGTAKPSAQELALAPHRLIDIRDPAESYSAADFRKDALKEMADITAAGRIPLLVGGTMLYFKALLDGLSPLPSADPQVRQRIEQQASELGWGALHQQLAVIDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTKISGETLPYRVHQFAIAPASRELLHQRIELRFHQMLDAGFEAEARVLFDRGDLHTDLPAIRCVGYRQMWSYLSGEIDYNDMVYRGVCATRQLAKRQMTWLRGWSSVQWLDSDKPGEALDSVIQVVSA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: LPXC_HAHCH
Sequence: MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGVVFCRTDLDPIVEIPARAENVGETLLSTTLVKSGVKIATVEHLLSALAGLGIDNCYVELSAAEVPIMDGSAGPFVFLIQSAGIAEQDAPKKFIRIKREVTVTDEDKRATFVPFDGFKVTFSIDFDHPVIKGRSQETVIDFSSTSFVKEVSRARTFGFMRDIEKLRAMNLALGGSMDNVIVVDDFKILNEDGLRYEDEFVKHKVLDAIGDLYLLGNSLIGEFKGHKSGHGLNNKLLRELLSQKDAWEVVTFEDAGEAPISYLKPVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: TREA_PIMHY
Sequence: MAKTTPMAKPSVGLLTLQVLVFCALTGSLASAGSIGHVTPRSDLCDSEVYCQGELLKTIQLGEVFKDGKTFVDHYQVNDPSVTVANFRKLMAETGGKPNKDQLTQYVKENFAQENEVIDWSPPDWQENPEFLQRVQDPVFRKWAKDLNDVWKIISRKVAPSVAEHPERHSIISVDNGFIVPGGRFQEFYYWDSYWVMEGLLLTGMKNTSRGILENFLSMVTRFGFIPNGGRVYYLMRSQPPLLIPMVDLYLTHTGDMQFLRDNIGTLEKELGYFLSQKTVDVTKNGKTYKMARYIVSSNGPRPESYREDYELAKNINDEAEKRRFYEDLKAAAESGWDFSSRWYISENGTRGSLSNIATRNIIPVELNAFLQRNARMLAQFHTTLGNPTKAKYYKDIATSYQQAIDDVLWSESEGVWLDFDLRNSQHRNYFFPTNVAPLYTQSFDSSKAQIYGQRAAAYLTRNGILDYMGGTPASLFPTGEQWDLPNAWPPLQSIIVQALRNSNEESAEKLAKELAIRWLRANHKGYSQSGQMFEKYDALNPGKFGGGGEYVVQEGFGWTNGVVYEFLNSYPNATPDDNVHMNNN
What are the official names of this protein?
Trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KHSE_SYNY3
Sequence: MVSFTVSVPATTANIGPGFDCLGAALGLYNHVTVTDPTDPEVDLLIEARGRDGEKISTTKDNLLYQAIAYFYQQTGQAIPPLKLEIDLEIPLARGLGSSATAIVGGLLAANQAAGNPCTTSEILQMAIAMEGHPDNVAPALLGGCQLAVKNGDHWQLVALDWPSKFVPVLAIPNFELSTEAARAVLPHQYDRSAAIFNASHLALLVQAFSQGRGDWLALALQDQIHQPYRQSLIPAYDQLHQAALAAGAYNLVISGAGPTLLAIADEVRAPQIASTLVETWHDAGIEAESHCLPIDTKGATITKLR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5DNU_SALHS
Sequence: MKQSHFFAHLSRMKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGQLNAERIALLAMYHDASEVLTGDLPTPVKYFNSQIAQEYKAIEKIAQQKLVDMAPDELRDIFAPLIDENAWSEEEQAIVKQADALCAYLKCLEELSAGNNEFGLAKTRLEKTLELRRSQEMDYFMAVFVPSFHLSLDEISQDSPL
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase YfbR, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_CLOD6
Sequence: MKLHELKPAEGAVRAKRRLGRGTATGQGKTAGRGQKGQWSRSGGGVRVGFEGGQMPLARRLPKRGFNNIFKKVYTEVNVEVLNRFENGTEITAELLKSTKTISKIGKDGIKILGEGNLEKALTVKAAKFTASAQEKIEKAGGKAELV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: AQPZ_PHOLL
Sequence: MLRKLAAELLGTFVLVFGGCGSVVFAAAFPELGIGFVGVSLAFGLTVLTMIYAVGHISGGHFNPAVTIGLWAGGRFRAVEVIPYIISQVIGGILAAAVLYVIASGQVGFDATTSGFASNGFGEHSPGGFSLQSAIVAEIVLTAIFLIVIIGATDRRAPPGFAPLAIGLALVLINLISIPITNTSVNPARSTAVAIFQNTWALEQLWFFWVMPIIGGIVGGGIYRLLFAEKQ
What is the function of this protein?
Channel that permits osmotically driven movement of water in both directions.  It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells.  It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
What are the official names of this protein?
Aquaporin Z.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YIDC_CHLL3
Sequence: MDRNSVTGLALIALIMIVWLQFMSPEKKPLQQVTDAGKARTEQVAAEINSDMQPAAVPATEDSFGMFAPAASGTERLTVIDNDLFHAVVSSKGATLKSLVLKKHLDGNLKPFDLVSDAKNGALSMLFLTREGRRIDTRDLYFAGSSLDTLHTIKGKETYALSYRLALSPRQSIEVSYTFTGDSYRIGYDVKLTGLSGSLAGNEYQVQWDGGLPYTEKNRDDEARSAQASAYLGGSLVKLDAEKDGRSYREEQSGDARWVAVRNKYFIAALIPEDRTAGFYLDGQKERGNAYENYLASLKMEVPASEEVVDSRFSLYLGPLDYNTVKAQHADIEKIMDFGWDWLTRPFAEFVILPAFTWMNRFVSNYGLIIIIFAFLIKLVTYPLSTASTKSMKKMAALQPMLKELQDKYKDNPAKLQSELGRIYKEAGVNPLGGCLPVVLQMPLLFAMFYVFRSSIQLRQHGFLWVKDLSVPDSILDFGFTIPMYGSHIALLPILMAVTVFLQQKITPTAQSNDQMKIMLYMFPAMMLLFFNNMPSGLALYYLMFNVFSVAQQFYINSTSSAADLPQVSISAPSRPKKKKSGSGK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRD_BART1
Sequence: MSFFRCIGRSALFMLDPEHAHRLAIVGLKSGLNGCQKVVDKRLSVTIAGLKFKNFIGLAAGFDKNAEVVDEIFRLGFGFTEIGTVTPKPQIGNPKPRLFRLKEDEAIINRMGFNNDGHQVVDDRLRICKKAGVVGVNIGANKDTVDKIDDYTVGIAHFYDVADYFTVNISSPNTPGLRDLQARDSLHLLLNAISKARKEQEKKHGFSIPIFLKIAPDLSEKELDDIAEEIKLSDFDGLIVSNTTLSRQGLNNSHFSNEEGGLSGRPLFERSTIVLAKMRQKLGKEIAIIGVGGVKDAQTALEKVKAGADLIQLYSGMVYEGPNLVITILKEILQMMQQDGVDNIKDYRDHNLEHWAKFPL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: OPSO_SALSA
Sequence: MDTLRIAVNGVSYNEASEIYKPHADPFTGPITNLAPWNFAVLATLMFVITSLSLFENFTVMLATYKFKQLRQPLNYIIVNLSLADFLVSLTGGTISFLTNARGYFFLGNWACVLEGFAVTYFGIVAMWSLAVLSFERYFVICRPLGNVRLRGKHAALGLLFVWTFSFIWTIPPVFGWCSYTVSKIGTTCEPNWYSNNIWNHTYIITFFVTCFIMPLGMIIYCYGKLLQKLRKVSHDRLGNAKKPERQVSRMVVVMIVAYLVGWTPYAAFSIIVTACPTIYLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQVSTQLNWGFWSRA
What are the official names of this protein?
Vertebrate ancient opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PPARG_RAT
Sequence: MGETLGDPPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
What is the function of this protein?
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids.  Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase.  It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.  Key regulator of adipocyte differentiation and glucose homeostasis.  ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer.  Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses.  Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.
What are the official names of this protein?
Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation (By similarity).
Protein: FMP32_SCHPO
Sequence: MYLKIPCNSIYHQFQPLFRARTVHKVRSLGLNGFYRKYHGFNSLRFVRVLQEAGIDDKKSETLMRLISNVYSDMHEKISDFSVTKEQQDRVMYQQKVDFAHLRSELQSIERQEMVALHSQVEQLFSDVERLKTSFRDQLNNSTSEARLQLNIDRLNHYDETASQDLKLRELSAEIDTEMSNFRTQLASFKTQTLQWVFGIVTGSGALLLAYVRLII
What are the official names of this protein?
Protein fmp32, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the CCDC90 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single-pass membrane protein.
Protein: TGT_STRTD
Sequence: MIDFPIKYRLIKKEKYTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKQMGSGIILANTYHLWLRPGDELIAKAGGLHKFMNWDQAILTDSGGFQVYSLAEKRDISEEGVTFKNHLNGSKMFLSPEKAISVQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSSHDLVSMDFPGYSIGGLAVGETHEEMNAVLDFTVPLLPENKPRYLMGVGAPDSLIDGVIRGVDMYDCVLPTRIARNGTCMTSNGRLVVKNAAYAEDFSPIDPECDCYTCKNYTRAYVRHLLKADETFGIRLTSYHNLYFLVNLMAKVRQAIVDDNLLEFRQDFIEKYGYNASNRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: TVB19_HUMAN
Sequence: MSNQVLCCVVLCLLGANTVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSI
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 19.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RDRP_I83A8
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTQSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: TIG_RHOCS
Sequence: MQITETSADGLRREFKVTVPADEIETRVANRLSEIGKTIKIPGFRPGKVPMALLKQRYGQSVMGEVLEQAVNDGSAKAVEEHKLRPALQPKVEVTKFEAGSDLEFSMAVELLPDFEPADMAAIAVEKPVVEVADAMVDDGLKRIAANRKTSAPLEAERPAQSGDIVVIDFDGSVDGEKRPGMKGEDHELELGSGSFIPGFEDQLVGAAKGEHRTVTVTFPENYHAAELSGKEAVFEVDVKDIRVPKAAEIDEDFAKSFGFDDLAGMRDAIRERMQADYASMSRMRAKRQLLDRLAETHDFPVPTGMVDIEFDQIWRRLQQELKDGEADPEDKEKDEEGLKAEYRAIAERRVRLGLLLSEVGRRNNITVTRDELGQAVVAEAQRYPGQERQVFDFFRNNPQAVEGLRAPIFEDKVVDFILGQVKLTERTVSVEDLMRDPEEDEGPTAAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: TR05_CURCL
Sequence: MTFVETVAVPDNEERPSAGHNRPVADSTKCPNAREMKVQNRVAQRTHHRRLKTKLEVLRERLKEPEKQVGEPARVQTSTSTLVSDAATSLADSMCLVPAVQNDQAMAFDFLMTPSPSVGNDCPSNDLETMRQAASVHSNTLGGAFPLNRSPCTENMTPESQVSLSTAPLCFTSVVPAELDMDAFCTLDSSDWSRPNEESLLRLANYSTSVSPTNVQWGVDENAPLQDRVRYMRDQAVAMGFGSLDDVVEAHYTQKLECTSPSFQEQRLSRNRRLSRLLSTLHNAAKDWSEWERRGLQEQVTQGAEDILVSELNSYITQRSMNSTDDKIITGGLLDEQSRLRQDVEERRRLQDSLPNLGALLTTLLSRSNAPNQDARRDTVLAMIKTMCFDQDENMSIS
What is the function of this protein?
Transcription factor that positively regulates the expression of the gene clusters that mediate the biosynthesis of KK-1, a novel cyclic decapeptide compound with potent antifungal activity.
What are the official names of this protein?
Transcription factor kkR, KK-1 biosynthesis cluster regulator.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EST1C_RAT
Sequence: MWLCALVWASLAVCPIWGHPSSPPVVDTTKGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNTTTYPPMCSQDGVVGKLLADMLSTGKESIPLEFSEDCLYLNIYSPADLTKNSRLPVMVWIHGGGLIIGGASPYSGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESAGGVSVSALVLSPLAKNLFHRAISESGVVLTTNLDKKNTQAVAQMIATLSGCNNTSSAAMVQCLRQKTEAELLELTVKLDNTSMSTVIDGVVLPKTPEEILTEKSFNTVPYIVGFNKQEFGWIIPTMMGNLLSEGRMNEKMASSFLKRFSPNLNISESVIPAIIEKYLRGTDDPAKKKELLLDMFSDVFFGIPAVLMSRSLRDAGAPTYMYEFQYRPSFVSDQRPQTVQGDHGDEIFSVFGTPFLKEGASEEETNLSKLVMKFWANFARNGNPNGEGLPHWPKYDQKEGYLQIGATTQQAQKLKGEEVAFWTELLAKNPPQTEHTEHT
What is the function of this protein?
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.  Involved in the extracellular metabolism of lung surfactant (By similarity).
What are the official names of this protein?
Carboxylesterase 1C, Carboxyesterase ES-1, E1, ES-THET, Esterase-2, Liver carboxylesterase 1, Neutral retinyl ester hydrolase, NREH, Retinyl ester hydrolase, REH.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Note=Microsomal membrane, lumen of endoplasmic reticulum.
Protein: Y1156_LIMRD
Sequence: MEIEKNYRINSLFEFYQPLLTKKQNDYLELYYGDDYSLGEIAENFHVSRQAVYDNIKRTESILEDYEAKLHLYAEFQVRNQQADRIQRYVRENYPDDATLNHLVNHLESLEEE
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein Lreu_1156.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.