Protein: GEDC_ASPTN
Sequence: MDFTPSTGTPGEFRRMKLTYFTNEFPSDDLPGLARQLHLHSKDRRHHILARFLQDATLAIREEVAQLPPALKDLLPPFESVLTFVEYPEMRKGPLCGSIDGVLLSTVELATFIGYFEEFPETYDFESAHTYLAGLGIGLLSAAAVSLSRTLADIAYVGSEVVRMAFRLGVLVDNVSEQLQPRELASHGTPDSWAYVLPNVTREAVQQELDVIHSGEGIPETGKIFVSAFSQSSVTVSGPPSRLKDLFRTSDFFRDRRFFSLPVFGGLCHAKHIYTETHVQQVVRTKPMDMLSARVLPRIPIFSPSSGSPFPAATATELFEGIISEILTQVIQWDNVIQGALDQINILSPSEFQVLVFRISLPIHDLMAAVNTELKGFQATTKEIMPWVSHTAKDRIPREPSQSKIAIVGMSCRLPGGATNTEKFWDVLEQGLDVYRTIPPDRFDVNTHYDPAGKRVNASHTPYGCFIEEPGLFDAPFFNMSPREAQQTDPMQRLALVTAYEALERAGYVPNRTPATNKHRIGTFYGQASDDYREVNTAQDVDTYFITGGCRAFGPGRINYFFKFWGPSYSIDTACSSSLATVEAACTSLWNGSTDTAVVGGVNVLTNSDAFAGLSRGHFLSKIPGACKTWDCNADGYCRADGVISLVMKRLEDAQADNDNILGVILGAATNHSADAVSITHPHAGAQAHLFRDVLRNAGVDSHDVSYVELHGTGTQAGDFEEMKSVTDVFAPLTKRRSPNQPLYVGAVKANVGHGEAVAGVTALLKVLLMLQKSVIPPHVGIKNSINPQIPKDLDKRNLHIPYEKQSWKSTPGKSRIAVVNNFSAAGGNTSVVLEEGPVTELTGVDPRPSHVVAISAKSKVSLKGNLERFAAYIDTNPGVSLSHLSYTTMARRHHHNHRLAAAVSDAEQLKKQLTSWMQSVESHRPISATGPPPVAFAFTGQGASYKSMNVELFHTLPSFREQMMHLDALAQQQGFPSFIPAIDGSHPQDHAHSQVVTQLALTGTQIALAKYWMSLGVRPEVVVGHSLGEFAALHIAGVLSAGDTLFLVGRRAQLLEQHCVQGSYQMLAVRASVSQIEEIADGRLYEVACINGPKETVLSGTRQEIRNIAEHLMTKGYKCTALEVAFAGHSAQLDPILDTYEQIATKGAIFHPPNLPIISPLLGKVIFDDKTVNATYMRRASRETVNFHAALETAQRISTVDDTTAWVEIGPHPVCMGFIRSTLQSTALTVPSLRRGEESWVTITRSLSSLHCAGVEVHWNEFHRPFEQALRLLDLPTYSWNDKNYWIQYNGDWALTKGNTFYSSQQQNSAAVDELPSGPRTSTVQKIVEESFDGRAARVVMQSDLMQSDLLEAAYGHKMNGCGVVTSSIHADVGFTLGQYVYKKLNPNTKVPAMNMASLEVLKGLVANKNTDKPQRFQVTVTTTDINSRILQLEWRNVHAHGPAEEPFASAKIYYCDASEWLLSWRPTLHLVQGRIQALERLAEAGIANRFSGRMAYNLFANSLVDYAGKYRGMQSVVMHELEAFADVTLTVEKAGTWTVPPYFIDSVAHLAGFIMNVSDAIDNQKNFCVTPGWNSMRFAAPLVAGGRYRSYVKMIPTVEDDSVYLGDVYILQNDMIIGMVGGIKFRRYPRLLLNRFFSPSDDSTAKTAAGETPPAPTTTAATAITAATSTTSTTSTASTGQPPKVDETSPVDSNSTAARALALVAKEAGMEVTDLQDDAIFANLGVDSLMSLVIAEKFREELGVVVAGSLFLEYPTVGDLKSWLLEYYS
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products (PubMed:7665560, PubMed:19549600, PubMed:24009710).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC (PubMed:12536215, PubMed:19549600).  The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC (PubMed:19549600).  The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodinanthrone (PubMed:24009710).  The next step is performed by the emodinanthrone oxygenase gedH that catalyzes the oxidation of emodinanthrone to emodin (PubMed:1810248).  Emodin O-methyltransferase encoded probably by gedA then catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:1444712).  Ring cleavage of questin by questin oxidase gedK leads to desmethylsulochrin via several intermediates including questin epoxide (PubMed:3182756).  Another methylation step probably catalyzed by methyltransferase gedG leads to the formation of sulochrin which is further converted to dihydrogeodin by the sulochrin halogenase gedL (PubMed:24009710).  Finally, the dihydrogeodin oxidase gedJ catalyzes the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to geodin (PubMed:7665560).
What are the official names of this protein?
Atrochrysone carboxylic acid synthase, ACAS, Geodin synthesis protein C, Non-reducing polyketide synthase gedC.