Protein: PKSF_ALTSO
Sequence: MDAFIDSEEVPMSSSSPNRVEPIAIVGFGFKFPQDITNAESFWKLLIERRSTMTEIPKNRWNIDGFYKEHGHRPGTVKNRGGHFLADDPARFDAPFFSIQPAEAECMDPQQRLLLETSYHALENAGIPMQAAMGTRTSVHVGCLLQEYSQISQRDAQMPGDYRIVGSSGLAMLANRLSWFYDFSGPSMTVDTACSGGLVAFHLACQELSAGSVDMSLVCGNNLCLLPDSTALLSSLNMMSKDSVCYSFDERASGYARGEGFGVLILKRLATAIADGDTIRGVVRSTGCGQDGNTPSITSPSQSAQERLIRETYARAGLDLGHTRYFEAHGTGTPVGDPCEAAAISNVFSCRTPKDPIFVGALKSNMGHPEGASGIAGVIKTLLVLEKGIIPPNVYPERINPAVAAAGPNLKFPLVPATWPTDGIRRASVNSFGYGGTNAHVVLDDALSFLRDHGLSGRHCTEILHASEGATKPAIFDALAINGEDGSYSTDTSACSEFFADNTPPDSMDDHETAPKLFILSAFDERATQRSISTFENWMRNHANDENDRQLLNDVAYTLAEKRTSFPWKSVCVALPNSLSQLSWSAPARARQRVNLCFVFTGQGAQWHGMGRELMIYPPFRDAMLRADRYFKSLGSAWSLIDELYLTSKEDSVIHQPELSQPICTALQMAIHDLLTSWRVCASISVGHSSGEIAAAYASRAISQESAWMIAYFRGLAVAIAQALNPSPGAMIAVQAPLKLGNTSWTSRMQNIRPISSLSACYNSPTSFTLSGSHSMLHQLAITLKQANIEVHILKIDVAYHSHYMKPVAGVYEKLLRTIEPGEQVEAQPSFVSTVTGKNVQQLNALRTSEYWQQNLCGSVKFSATLQSICARQDASTLFFVEIGPHSVLRSPLGDILKESGRDVAIDYSSVLRRDRAADITALECAGKLHTIGASIDITEVNKESEKSPRFLPSLPSYQFEDKKKYWLEGRTSIQYRQTQFVHHELLGSRTPDWNEHEARWTNRILLDQSPYLHDHQINGLCLMPAAGMLTMAIEATRQYYGHRAENASGYKLKDVTFTKAMTLSADARGTEIQLTLRPAAAESRDVQPGSLWNQFSLFVHEDGGWHLCCKGYVAIEYDDRRESSGELAESATAMEEKKQAFLAASQECRIAIDSADIYGAFGQAGLTYGPTFKGMRNVKWDQRNQATGTIGLRDWQRHAKFSYSDPHFIHPAALDTILQTTFPAYSIYAKDSSATTVPTGFSNAWFSVKLMRDPSDPQDVVVHAKVAGRGFRNKLFSITAAFANTQELCFYGDLETSTIGRNSPSADNTEVPRSLYRIDWQPAEFHRPTAVSPPSALSKSCIHIIYDDSEPLQSELMQALRRTMSAQDDVGVALVTWSSVSQHELDNATCVFLPGLDGNLLRRMQEDGLANIKSLLLKASTLIWITFQHQTIDQSPTEGLVSGLVRTLATESEDYRLVSVSLNPETGLDTVATNITKVATALLEPQDDPEDEYCEIDGRLCTPRVVDDAELTVQALSTKDTAVSITKPWSELDSPKLTIGAAGILKTLHYEQTSIQMDELASDDVVIQVKAVGLNTRDALVALGQVHDESFGSEIAGVVVNTGSSHDAGFQIGDRVFGVTRGGVAQLARCKASQLQRVPDRMSFCEAAAYPVAFCTAYYVLTQYCGTNSGDSILVHDAASVLGQAIIKIAAIHGYTKIFATVSSAGGAHFLENSLHVPKSNIFSTDSLDFQHGIRHLTNGEGVAVVVGSEDHLQDSWPCIAPFGRFVGVGEKDVFHSTANGSKEIVLPPTTKNIAFVSVSFQDLAESYMFKDIFKHALMLIEDAQVTMALPPTVFKQSEIEPALRRLTDVDVVEKIVIEMDSDEVVEMEPAQNSTKPLFRPDASYLIAGAFGGIGQSIARWMVQHGAKLLILPSRSPVEGTGSERDHFVQELKAQGAEVYAPVCDIADHDQLRKMLVSFSHLPAVKGCIQAAMVMRDSSFAKMTIEQWHQSLAPKVDGSWNLHRLLPLGLDFFVMLSSSTGIMGSFGQSNYTVGNTYQDTLAAHRMRHGQRAHALALSMVTGVGYVAQNDQVQALLRVRGMLEEVPMEDIYNLLRFCCDPDRVDASTVGSQIITPLTLPADLRAMGIVAPLGSTRPIYHYLDTLPSRLSSDTASAEAKNRPSYKLSEATSLVQATDIVVEAIQTQLSSLLVVSKDDIDSQRAIYRYGVDSLVAVEMRNWFSKAIGADVGTADIMSDISIWLLAVKVAGKSKFVRNELKE
What is the function of this protein?
Reducing polyketide synthase that catalyzes the formation of a C22 intermediate attached to the ACP.  Release by intramolecular hydrolysis by the enolized delta-carbonyl would give the pyrone product aslanipyrone (PubMed:16642517).  Alternatively, KR-mediated reduction of the beta-carbonyl of the C22 intermediate would form a beta-hydroxy thioester intermediate, which could be a substrate for a further KS-mediated condensation of an additional C2 unit to form a C24 intermediate, which cyclizes by aldol condensation followed by decarboxylation to form aslaniol (PubMed:16642517).  Neither aslanipyrone, aslaniol, nor their derivatives have been detected in A. solani, probably due to a low abundance and/or extensive post-PKS modification.  It is assumed that the branching point from C22 to C24 is the result of KR activity on the C22 intermediate anchored to the ACP (PubMed:16642517).
What are the official names of this protein?
Reducing polyketide synthase pksF, RD-PKS F, Aslaniol synthase, Aslanipyrone synthase.