PharMolix/UniProtQA huggingface dataset:
Protein: RME6_CAEBR
Sequence: MSEAVEKIRSHDKYRQFYELATKIRNQKLLADAESASLHRHKQEVADLEVKLLTEAWRSSYWTNVSRQLKSQSLDPSYACRLLKEISDTEALAAYKHFGHHYSTLNQLLTVLYMEPTSVAELLNMWDQNDVTTNDNLIQTFFHLVYSCGLYPDDELKIAQVVCYLLKLQLVKSGSQMRTMLRKETSISTRFYKYFVEQMHPTMVYLTKALRKSVLNVIQLGNFWLDVDMKQSSSRFLSDGRQNSERLPEYRALVVSKLVDFVDNFLENISLALSMLPPNLNWIVRDIFCSLYEIVDDMSAIELSHACKDMIVSNLLCPAIISPQKFGVVDNDVRIGSIVNHNLAQIAMIIQMISLREFESPPEEYREFLSQCRNTHLISEMMDSLLVENMAPDVEITSLIASGKSESDLETKSNFVGSLADANKLIKMIRETPPTTDLKISRIVSVCQKMPESFASTVEKLHVENSEDSPKLSALRNIHRKVQKSFKRTGDSFYDPNELHMKTENYGGVFEKENFDRKLREASEVERRKQEARKQKQLKETELLIMDNISSDSAPITIKASAATNAPIANNNFTENKDLIDFSTLYTTTDDVISIPSEPSKEEKSVEKPNVNNVSVDAPVEALQIGESRGGLAKLKNFSDRMKKGITQSNTLSDIRDHLRRSSSLAKQPSGMVSSASAQNIPDTEKGDSILAKYASNSSIKIEKSTFTKLTDTKSMPKNTEMSEPYYSPENLTSCRAFKDTLRKMITVLGNVSYLPKIGCRSEMKEMSKKVRLDSFLDGVLVETEHRREYGQAAQLREVKRCIELFENEGVEILMDHLVGNEVEQDFLVRQMREERAILMRKSNDISSMEQRVLLNRRLTEQILVDNLIQTFLETGFQNSKLASGKTPEVVAVGKFYSEFKFLQAHDERAEFLQNLLTYLRERLMQNYDWNFATESMIARAMTTMERFVMFAVYEIAFWPNREMDQKKDKLLQSVIGKASSSVTPVHEALKIPEHLLGEAPWPSAQAELSMLDNYVTAQEKLNCLVRCCDVINNLVALSSKNAVASADDLTPVLVFVIIKANPRSLLSNLQFIETFAGDQIESGRDAYYWVNFKSAVEYIKTIL
What is the function of this protein?
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis.  Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits (By similarity).
What are the official names of this protein?
Receptor-mediated endocytosis protein 6.
What is the protein family that this protein belongs to?
Belongs to the GAPVD1 family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle.
Protein: RL22_PSEFS
Sequence: MEVAAKLSGARISAQKARLVADQIRGKKVGEALNLLAFSSKKAAEIMKKVLESAVANAEHNEGADVDDLKVSTVFVNEGRSLKRIMPRAKGRADRIVKRSCHITVKVADK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: TPX_STAAS
Sequence: MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSDASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: RS5_BACCR
Sequence: MMHRIDPSKLELEERVVTINRVAKVVKGGRRFRFAALVVVGDKNGHVGFGTGKAQEVPDAIRKAIEDAKKNLIAVPLVGTTIPHTINGHFGAGEVFLKPAAEGTGVIAGGPVRAVLELAGVQDILSKSLGSNTPINMIRATVNGLSELKRAEDVAKLRGKSVEELLG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: DOC2B_HUMAN
Sequence: MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD
What is the function of this protein?
Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes.  Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion.  Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells.  Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).
What are the official names of this protein?
Double C2-like domain-containing protein beta, Doc2-beta.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane in a calcium-dependent manner.
Protein: Y3628_AERS4
Sequence: MPAVLREGDELILHLMIQPKASRDQIVGLHGDELKVAITAPPVDGQANSHLIKYLAKQFKVAKGQVRIVRGELGRHKTVAIESPRQIPAEIHALLETQG
What are the official names of this protein?
UPF0235 protein ASA_3628.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: ARPC3_SCHPO
Sequence: MPAYHSSFLSLTDVPTTGNIAMLPLKTKFRGPAYPADESQMDIIDECIGLFRANCFFRNFEIKGPADRTLIYGTLFISECLGRVNGLNYRDAERQLNSLALENFSIPGSAGFPLNALYAPPLSPQDAEIMRTYLTQFRQELAYRLLSHVYATEKDHPSKWWTCFSKRRFMNKAL
What is the function of this protein?
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 3, Arp2/3 complex 21 kDa subunit, p21-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch.
Protein: VPR_HV1SE
Sequence: MEQAPEDQGPQREPYNEWALELLEELKNEAVRHFPRLWLHGLGQHIYNTYGDTWEGVEAIIRILQQLLFIHFRIGCQHSRIGITPRRRVRDGPGRS
What is the function of this protein?
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus.  This function is crucial for viral infection of non-dividing macrophages.  May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: METN_RHOPS
Sequence: MSEPFMNAPWQPPGDHPALKSPQPTGILIDSVRKLYPARKASAEVVALDDISLNVPKGSILGVIGRSGAGKSTLIRLINGLDKPTAGRVVVNDVEITSLDEPALRRARRSIGMVFQHFNLLSSRTAFANVALPLEIAGTPKAEIEKRVLPLLDMVGLADKRDRYPAELSGGQKQRVGIARALATEPAVLLSDEATSALDPETTDQILDLLKQINRDLHLTILFITHEMAVVKALADRVAVIEAGRIVEEGATFDVFATPRHEVTRRFVSSVTGSGAPDWLLAQLQPLQPPGGKAVLRVTFKGSDASQPLLSRVARTLGVDLNILFGQVEMIAGHPFGTLIVSLDASPDVLRQVIAQLSAGNNLVEQLGYVA
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PUS5_DEBHA
Sequence: MKPTFLKCLQGIDKNHAYRQINIIDIHSRYLIINKPSGIQCNGTKSHSNYLLPQLYKQLKAHFSANNPNYKLNPDQYKVVHRLDKYVSGGLIIARGKNANAFRKSFSNQNTNLSVKRKYIGLVPIPNTVSFKQHLHEFGDLKVQHENEVRYLNRPESVTDKKGLIFKDDSLTEGIINFDIVALPKDDRRNKNTGELVTYSALTKFKILHSMSQVPTNEQISRFPKLYKNKTIYPIIIELETGRKNQIRDHILQAFKVSLLNDDKFIDFKMVQKSNTANINSEVYNSNQIGLHSAYISISKSSFANEYVIPIPEGDEYLWKGFLDENSFIKTINRELITF
What is the function of this protein?
Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA.  May modulate the efficiency or the fidelity of the mitochondrial translation machinery.
What are the official names of this protein?
21S rRNA pseudouridine(2819) synthase, Pseudouridine synthase 5, Pseudouridylate synthase PUS5, Uracil hydrolyase PUS5.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PPID_CANGA
Sequence: MTRPKAYFDISIGGTPKGRIVFELYKDVVPKTAENFLKLCEGKSGMAKSKPDVPLSYKGSIFHRVIKDFMIQFGDFTNFDGTGGESIYGEKFEDENFEIKHDKPFLLSMANAGPNTNGSQAFITCVPTPHLDGKHVVFGEVIEGKRLVRLIEKQQTEDGTDKPMHDVKVEGCGLLPDDYEVPADAEQTPTDEFGDNYEESLKDDAKVDLKKVETVIKAIETVKDIGTKQFKEQNYEVALAKYKKCDKFLKEYFPDDLNEEDMKKINDFKVTVPLNIAIAALKSKDYRSVMVACSEVLYAEAADAKAKAKALYRRGLAYYHVNDTDMALADLEMATTFQPNDAAIAKAINDTIKKRKQETEKQKKSLSKMFG
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase D, PPIase D, Rotamase D.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_BUCAP
Sequence: MNKYKNIKRRKSNRIYVGNVPIGDGAPISVQSMTNTQTTNIEETIKQIIKLKKVGVDIVRISVPTLEAAESFKIIKLNVDVPLIADIHFDYRLAIKSIKYGADCLRINPGNIGNKRRILDIVNCAKDKNIPIRIGVNAGSLENDLLKKYKSPIPEALVESAIRHIEYLDSLNFNQFKVSVKTSDVFSAIEANEILAKKTVQPIHIGITESGALRNGIVKSSIGITSLLLSGIGDTLRISLAADPVEEVKVGYDILKTLGIRFRGVNFIACPTCSRQEFNVIDVVNQLEKNLEDLSTPMNVSIIGCIVNGIGEAKVSTLGIVGGSKTSALYKDGIRQKNKLKNQEIIKELEIKIRKKAKSLDKLKKII
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: YFIS_ECOLI
Sequence: MEVGKLGKPYPLLNLAYVGV
What are the official names of this protein?
Protein YfiS.
Protein: BIOD_LAWIP
Sequence: MQFFIIGTDTNVGKTIVSSWLCLHTAYDYFKMIQTGSINGTDSDILKKLTYSKIHKEAYCYKEPLSPHLAAKLEQDEININNIILPNASNLVIEGAGGLLVPINQQYLLLDIISYLMLPVILVTHSRLGTINHTLLTLQALKSKGIEVVGVIVNGKPNQDNCDAITWYGKTTILAQFPFLSTITKTTLRNIPLTQELKQLFIV
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIDA_USTMA
Sequence: MSAPTLDVESPLAASTSSLRAMNMVSSHTTVAKDEIYDLLGIGFGPAHLALSISLRESSEANETNFKAHFLEKRGHFAWHPALLLPGSQLQVSPLKDLVTLRDPASTYSFYNYLHSHGRLARYINKEQGVPSRREWTSYLAWAARRMNQAVSYGQDVISIEPLALASASPDAKQDTVAVRPASAQEADSLCLYQVRIRDESTGHIVNRYARNLSVAVGGVPKLPPAFQAAWDEQQRAPHSIPRLVHSGFYIPSMLKLEPELHKAASLRHPDAAAQLDDSSRLRLAVIGAGQSSTEMFMNLHSRFPSAIVTMIFRASALVPSDDTGFVNSAAFDPERTDEFWQASETQRRKWLQEFKRTNYSVVRTDLLNELHDAMYDKYEVQLPEELQDPTEKQAGRMEMRRCTEVVEVTPLDDGIQLTMRDNLRNAKLETIRFDAVFLGTGFIRSPSKMRFLEQLKPFYPALDAEWMSRDTIAEEDEVSKSIDVEDEEVIERRREMLRGITRDYRLVPASAMQSDAVRSGKSSPGSGSDASSTSSQQTLASENSTENLPEASLYVLGGNEATHGLSDSLLSIVAHRAGELTTSLLQRLPRTRRGTASSAATQPAASTVASAAKTSPTVSVTQTKARQAAQVVNDKLAALSGLHLDATS
What is the function of this protein?
Catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as ferrichrome.
What are the official names of this protein?
L-ornithine N(5)-monooxygenase, OMO, L-ornithine N(5)-oxygenase.
What is the protein family that this protein belongs to?
Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.
Protein: PRX8_PENRW
Sequence: MAVIFSSSALGSHTHVDRHLVRQPIRDLENNVDMLDHLSRVLALSSQYHALGAAIALFACACAYALVAPRQPPKFPAPQLYDETGPIDLIALDKTIKEGFQNYKGKYFTLKEAHGETVILPTKFMEELKALPDNMLNLDDEIDERFLSEYSLFTTTSVGGRISTVVNSIKNELTKTLGNLMGDIHEEVVYSFQELIPPCDDWTELDIQSKLVHIVALVSGRIFVGLPMSRNQEYLDCIIEFTLNVFFAVPEIRAYPRLLRWTSRYLNTKVRAVHKSLATMRRLMAPIIDDTKQQLEMGTGPHNMCAWNIKNSNQKERDSLNIQAQMQLATSMAAIHTTSMTVTNAIFDLAARPEYLQPLRDEFQDLRAIEPLPYLDKTSMPKLRKLDSFLKESHRLSPISLLNMRRKIVQPITLHDGTVLQPGMHIAFPLHQISNDEDLWENPSQFDGFRFQKLRDLPGNESKYQFTATGTNNLDFGHGVHACPGRFFAANEIKMILVHLIDNFDFKFKGDIGRPDSLWTPGGYHPDPSVRVLLKRRLKA
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase prx9 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699) (By similarity).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase prx11 (By similarity).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:24239699).  The cytochrome P450 monooxygenase prx8 also plays a role in this step (By similarity).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:24239699).
What are the official names of this protein?
Cytochrome P450 monooxygenase prx8, PR-toxin biosynthesis cluster protein 8.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RRF_ACIB3
Sequence: MINDLKKDSEQRMLKTLESLEQGFAKVRTGRAHPSILNGVMVPYYGSDVPLNQVANVGVEDSRTLIVQPFERTMVAAIDKAIRESDLGLNPITADSIRVPLPALTEETRRDMQKIARSEAENAKVAIRNIRRDVLGDIKALLKEKEISEDDERRAGDDIQKITDKYVAEVDKRLAAKEAELMKV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPPH_VIBVY
Sequence: MIDGDGYRLNVGIVICNNHGQVFWAKRYGQHSWQFPQGGIDDGETPEQAMFRELYEEVGLTHKDVKIIASSRHWLRYKLPKRLVRWDSKPVCIGQKQKWFLLRLECDESKINMQKGSSPEFDGWRWVSYWYPVRQVVSFKRDVYRRAMKEFASLAMPFRERKLKGKKVKRRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: CADM4_HUMAN
Sequence: MGRARRFQWPLLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGHKRKEEFFI
What is the function of this protein?
Involved in the cell-cell adhesion.  Has calcium- and magnesium-independent cell-cell adhesion activity.  May have tumor-suppressor activity.
What are the official names of this protein?
Cell adhesion molecule 4, Immunoglobulin superfamily member 4C, IgSF4C, Nectin-like protein 4, NECL-4, TSLC1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: REX_LEUMM
Sequence: MTQQPKIPRATAKRLPIYFRYLTFLHDAGKERISSSELSEAIKFDAATIRRDFSYFGALGKRGYGYDVKALLDFFANVLDQDSLINVALIGAGNLGQALLNFNFHQSSNMRIAAAFDADEKRTGTILSGVPIYSMEELQEQITAQRINIAILTVPQGVAQEITNQLVETGVKGILNFTPVRVTVPTGVRVQNVDLTNELQTLVYFIENYGSITTGL
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_SHEB8
Sequence: MPLTVNCPICKAPVEWVPQSAFKPFCSERCKLIDLGDWASEKHVIPVKAEFDPEAFDEFDLDEGDFFKE
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: PURA_SCHPO
Sequence: MASVRETGVNVSNDGITVVLGSQWGDEGKGKLVDILCDNVDVCARCQGGNNAGHTIVANGVTYDFHILPSGLVNPKCQNLIGSGVVVYLPAFFSELEKLEQKGLKCRDRIFISDRAHLVFDYHQRADALNEAELGKQSIGTTGKGIGPAYSTKATRSGIRVHHLYHWAEFEARYRKNVADLQKRYGAFEYDVEAELIRYKELAQRLKPFVIDAVAFMYEALQSKKRILVEGANALMLDLDFGTYPFVTSSNTTVGGVCTGLGVPPQRIANSIGVVKAYTTRVGAGPFPTEQLNEIGDHLQSVGREVGVTTGRKRRCGWLDLVVVKYSTMINGYTSLNLTKLDILDALDEIKVAVAYIINGKRIETFPADLDSLEEAEIVYETFPGWKVPTTGITHWDQMPENAKKYIEFIEKFVGVPITFIGVGPGRDEMLVKE
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_NOCSJ
Sequence: MTAGATLPTAASAALFERARAVTPGGVNSPVRAFNAVGGTPRFIRSARGAWLTDADGNEYVDLICSWGPMLLGHAHPEVQAAVSAAVARGTSYGAPTEPEVELAEEIAARAPVERVRFVSSGTEATMSAIRLARGFTGRDVVVKFAGCYHGHVDSLLASAGSGLATFAVPGTPGVPESSTALTLVLPYNDRAAVEKAFAEHGDRIACLITEAAPGNMGVVPPDADGSGGGFNGFLAETCARHGALFVSDEVMTGFRASRQGQWGLDGAVEGWRPDLMTFGKVMGGGFPAAAFGGRADVMSRLAPEGPVYQAGTLSGNPIATTAGLATLRLATDDVYAHIGAAADTIKTAASDALSRAGVEHVVQAAGTMFSVFLTAGPVRDFADASRTDVAAYAAFFHAMLDQGVYLPPSAYEAWFLSSAHDDRAVQTVLDALPTAARAAAAAQT
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGF_DANRE
Sequence: MRWSMLVLLLLSCSQTFAQRPGDICPQNPHHGQDVTANTVPTVDPKLFNKRRYRSPRVLFSEHPPDSEPSRSRTKRKAGPPQHRGVYSVCESISHWEGNKTKATDITGNEVTVLPDVIINNSKKKQYFFETTCSSGRTGGSGCLGIDARHWNSYCTNSHTFVRALTSFKNLVAWRLIRINVACVCVLSRKSWRA
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons (By similarity).
What are the official names of this protein?
Nerve growth factor, NGF, zNGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: PNP_STRAW
Sequence: MENETHYAEAVIDNGSFGTRTIRFETGRLAKQAAGSAVAYLDDDTMVLSATTASKKPKENLDFFPLTVDVEERMYAAGKIPGSFFRREGRPSEDAILTCRLIDRPLRPSFKKGLRNEIQVVATIMALNPDHLYDVVAINAASASTQLAGLPFSGPIGGVRVALINGQWVAFPTHTELEDAVFDMVVAGRALEDGDVAIMMVEAEATEKTIQLVAGGAEAPTEEVVAAGLDAAKPFIKVLCKAQADLAAKAAKPTGEFPVFLDYQDDVLEALTAAVKSELSQALTIAGKQDREAELDRVKEIAAEKLLPQFEGREKEISAAYRSLTKSLVRERVIKDKVRIDGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLSPVTRKRYMHNYNFPPYSVGETGRVGSPKRREIGHGALAERAIVPVLPTREEFPYAIRQVSEALGSNGSTSMGSVCASTMSLLNAGVPLKAPVAGIAMGLISQEINGETHYVALTDILGAEDAFGDMDFKVAGTKEFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMMEAIDTPDEMSPNAPRIITVKIPVDKIGEVIGPKGKMINQIQEDTGAEITIEDDGTIYIGAQVGSQAEAARATINGIANPTMPEVGERYLGTVVKTTTFGAFVSLLPGKDGLLHISQIRKLAGGKRVENVEDVLGVGAKVQVEIAEIDSRGKLSLIPVVEGEGDDEKKDDTDK
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSD_SALSV
Sequence: MKKGTVLNSEISSVISRLGHTDTLVVCDAGLPIPNSTARIDMALTQGVPSFMQVVDVVTREMQVEAAILATEIKQQNPQLHETLLTHLEQLQQHQGNTIKISYTTHEQFKKLTADSQAVIRSGECSPYANVILCAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMB_TRIV2
Sequence: MKLFVYHTPELTPKDQVPDCAIAVDVLRATSTIATVLSAGGEAVQVFSDLDELIAVSETWPPQKRLRAGERGGGKVAGFELGNSPLDCTPELVEGRRLFISTTNGTRALKRVQDSATVLTAAFINRAAVVQYLLEKQPETVWIVGSGWEGSYSLEDTACAGAIAHSVVEKSQLPPEKLAGNDEVISAIALYSQWQDNLLGLLHHASHGQRLLRLECHEDLKYCSQTDVLTVLPIQQEAGVFKTKN
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.