PharMolix/UniProtQA huggingface dataset:
Protein: EFG_PROM5
Sequence: MARDFPLERVRNIGIAAHIDAGKTTTTERILFYSGVVHKIGEVHDGAAVTDWMDQERERGITITAAAISTSWQDHRINIIDTPGHVDFTIEVERSMRVLDGVIAVFCAVGGVQPQSETVWRQADRYSVPRMVFVNKMDRTGADFLKVNKQIKERLKANAFPIQLPIGAEGDLTGIIDLVSNKAYLYKNDLGTDIEEAPIPDEMKDEALEWRSKLMESVAENDEELIEIFLDKGELTEDQLKKGIREGVLKHGLVPVLCGSAFKNKGVQLVLDAVVDYLPAPVDVKPIQGVLPNGKEDIRPSDDNAPFSALAFKVMSDPYGKLTFVRMYSGVLSKGSYVMNSTKDAKERISRLVILKADEREEVDELRAGDLGAVLGLKNTTTGDTLCTTDDPIVLETLFIPEPVISVAVEPKTKGDMEKLSKALQALSEEDPTFRVSTDQETNQTVIAGMGELHLEILVDRMLREFKVEANIGAPQVSYRETIRSSSRGEGKYARQTGGKGQYGHVVIEMEPAEVGKGFEFVNKIVGGTVPKEYIGPASNGMKETCESGVLAGYPLIDVKVTLVDGSFHDVDSSEMAFKIAGSMAFKDGVKKCNPVLLEPMMKVEVESPDDFLGSVIGDLSSRRGQVEGQSVDDGLSKVQAKVPLAEMFGYATQLRSMTQGRGIFSMEFANYEEVPRNVAEAIISKNQGNS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_METSB
Sequence: MAAAKFTALLIAGPTASGKSALALRLAEKLGGILINADSMQVYRDLRILSARPSAEEELRAPHRLFGAIDGAVNFSVGLWLEAARNILEEARQAGALPIFVGGTGLYFKALTQGLSDIPAVPDDIRAKLRARTEGVAATELHAELSARDPLMAARLRPSDPQRLLRALEVLEATGRSLASFQSRRGPPVLDPAATRAIFLSPERAALNLRIDERFEAMLASGAWAEVEALRRRGLDPALPLMRAHGVPHLIAHLEGKIPQDEAIRLGKRDTRAYARRQFTFARHQLPGFVWAEPREAEALALA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: NIFH_METMI
Sequence: MVRKIAIYGKGGIGKSTTTQNTVAAMAHFHDKKVFIHGCDPKADSTRLILHGKQQVTMMDTLREKGEDECTPDKVIEVGFGGVKCVESGGPEPGVGCAGRGVITAITLMEQHGVYEDDLDFVFFDVLGDVVCGGFAMPVRDGKADEIYVVASGEMMALYAANNICKGMVKYAEQSGVRLGGIICNSRNVDGELDLLQEFCDKIGTQLIHFVPRDNIVQKAEFQKKAVVDYDDTCNQALEYKELARKIIENENLVIPTPMTMDELEELTSKYGFLD
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein, Nitrogenase Fe protein, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: NDHH_PROMM
Sequence: MSQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTSVMFVPYVSRMDYAAGMFYEAIVVNAPERLANISVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFRIGGVACDLPWGWLEKCQDFCDWFGPKIDEYEKLITNNPIFRRRIEGLGAIGRDEAINWSLSGPMLRASGVPWDLRKVDHYECYDDFDWDVAWEKEGDCYARYRVRIEEMRQSLKILRQACDMIPGGPTENLEAQRMAEGKTSPFMGFDYQYVAKKVAPTFKIPNGELYTRLESGKGEIGVFLQGNNDVTPWRFKIRAADLNNLQILPHILKGAKVADIMAILGSIDVIMGSVDR
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase subunit H, NDH-1 subunit H, NDH-H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LAAT1_CAEEL
Sequence: MKTGGLSDFADFGEEDANCTQGIQWIKDVFTDCVDTDLKLLGFIIGLISLALWLIPLFPQLWQNYKTKKCEGLSLAFLFFWLVGDTCNMLGAILTNQQPIQKIIGVYYIIQDLVLWTQYGYYLKIYNRPTTSSARSNTIVVPVLALASVGSFFVFESALPPVGDHRVKRSFLESLNHQEGLPLEGILKMWPIFTSYTDMLGYIIGSMAAVCYFGGRIPQIIKNYRHSSCEGLSLTMFYIIVAANFTYGISVLLATTSWLYLLRHLPWLAGSLGCCCFDAVIISQYYLYRPKTPLAEDTERAGLLNSQDDSD
What is the function of this protein?
Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes (PubMed:22822152).  May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function (PubMed:25124690).
What are the official names of this protein?
Lysosomal amino acid transporter 1.
What is the protein family that this protein belongs to?
Belongs to the laat-1 family.
Protein: S39AB_MOUSE
Sequence: MLQGYSSVVQALLGTFFTWAMTAAGAALVFIFSSGQRRILDGSLGFAAGVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHLGATEDPQTALALNLDPALMKKSDPRDPTSLLFPESELSIRIGSTGLLSDKRENGEVYQRKKVAATDLAEGVAPSGSMHGSSGQPGGSSWRRIALLILAITIHNIPEGLAVGVGFGAVEKTASATFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWKAFWYGQLSGMVEPLAGVFGAFAVVLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASWASILGFVVMMSLDVGLG
What is the function of this protein?
Functions as a cellular zinc transporter.
What are the official names of this protein?
Zinc transporter ZIP11, Solute carrier family 39 member 11, Zrt- and Irt-like protein 11, ZIP-11.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Golgi apparatus.
Protein: MIS_HUMAN
Sequence: MRDLPLTSLALVLSALGALLGTEALRAEEPAVGTSGLIFREDLDWPPGSPQEPLCLVALGGDSNGSSSPLRVVGALSAYEQAFLGAVQRARWGPRDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPGGAGPPELALLVLYPGPGPEVTVTRAGLPGAQSLCPSRDTRYLVLAVDRPAGAWRGSGLALTLQPRGEDSRLSTARLQALLFGDDHRCFTRMTPALLLLPRSEPAPLPAHGQLDTVPFPPPRPSAELEESPPSADPFLETLTRLVRALRVPPARASAPRLALDPDALAGFPQGLVNLSDPAALERLLDGEEPLLLLLRPTAATTGDPAPLHDPTSAPWATALARRVAAELQAAAAELRSLPGLPPATAPLLARLLALCPGGPGGLGDPLRALLLLKALQGLRVEWRGRDPRGPGRAQRSAGATAADGPCALRELSVDLRAERSVLIPETYQANNCQGVCGWPQSDRNPRYGNHVVLLLKMQVRGAALARPPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCR
What is the function of this protein?
Plays an important role in several reproductive functions.  Induces Muellerian duct regression during male fetal sexual differentiation (PubMed:3754790, PubMed:34155118, PubMed:8469238).  Also plays a role in Leydig cell differentiation and function (By similarity).  In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:14742691).  AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression (PubMed:20861221, PubMed:34155118).
What are the official names of this protein?
Muellerian-inhibiting factor, Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MIS.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: EPI1_PHYIT
Sequence: MKSALLFTLVVAAVHAQSPQVISPAPRRESNEIDCPEYCLDVYDPVGDGEGNTYSNECYMKRAKCHNETTPPAWKDLVLITGSSTGEQPPSKKCSTVCPDVELPVCGSNRVRYGNPCELRIAACEHPELNIVEDSGKACVGSKVTPQEG
What is the function of this protein?
Secreted effector that interacts with and inhibits the pathogenesis-related P69B subtilisin-like serine protease of host tomato (PubMed:15096512).  Inhibition of host proteases by a pathogen extracellular protease inhibitor forms a specific type of defense-counterdefense mechanism between plants and microbial pathogens (PubMed:15096512).
What are the official names of this protein?
Extracellular protease inhibitor 1, Secreted effector EPI1.
What are the subcellular locations of this protein?
Secreted. Note=Localizes to host apoplast where it targets defense proteases for inhibition.
Protein: ADE_PSEE4
Sequence: MYEWLNALPKAELHMHLEGSLEPELLFALAERNKIALPWADVETLRGAYAFNNLQEFLDLYYQGADVLRTEQDFYDLTWAYLQRCKAQNVIHTEPFFDPQTHTDRGIPFEVVLGGITQALKDGREQLGIGSGLILSFLRHLSEDEAQKTLDQALPFRDAFVAVGLDSSEKGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEAIDLLKIQRIDHGVRAIEDERLMQRIIDEQIPLTVCPLSNTKLCVFEHMSQHNILDMLERGVKVTVNSDDPAYFGGYVTENFHALYEHLGMTQDQARRLAQNSLDARLVR
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: HSCA_BURO0
Sequence: MALLQISEPGMAPAPHQRRLAVGIDLGTTNSLVAAVRNSVPEVLPDEAGRVLLPSVVRYLEKGGRRIGHEAKEQAATDPRNTIVSVKRFMGRGKAEVEGAANAPYEFVDAPGMVQIRTIDGVKSPVEVSAEILATLRYRAEDSLGDELVGAVITVPAYFDDAQRQATKDAARLAGLNVLRLLNEPTAAAIAYGLDNAAEGLYAVYDLGGGTFDLSILKLTKGVFEVLAAGGDSALGGDDFDHALFGHVLAQAGIDAKTLAPEDVRLLLDRVRVLKETLSSAPEAALDVTLSSGAHLVQTISHDTFASLVEPLVQRTLTPTRKALRDAQVTPADIKGVVLVGGATRMPVIRDAVAKYFGQPPLVNLDPDQVVALGAAIQADLLAGNRGTGDDWLLLDVIPLSLGVETMGGLVEKIIPRNSTIPIARAQEFTTFKDGQTAMAIHVVQGERELVADCRSLARFELRGIPPMTAGAARIRVTYQVDADGLLSVFAREQLSGVEASVVVKPSYGLADDDIAKMLEDSFKTAEIDMRARALREAQVEAERMLEATQAALAADGELLEADERAQVDTLAAALRAVAQGDDTNAIEAATKALADGTDEFAARRMDKSIKRALSGRRLDEI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL149_PLAVT
Sequence: MRNGVVLFGLFFIGYSSCVLASLVEKSDVESTHAEQWDSNGKRTLQADDPERILAEERNMEQALLPAAEAIGKIKVSEKAVPRASLGSTLNPMKWPKRILDKVRLWLARIRLNLLKRTTVGEDSIDRAMMNGLTPFYLKKIKNDIMHYSSSVPHDKIKIEEDYDFYVKHFFGQFKGLYKDPPVFAVDKWNKLEEGMTKAEQNGNRRASDKVSRNIDKGLSIDQLFSLDISPFVYMRLLEKRGVFKDVENNMDKIDHLKDYVKVYKEHLMA
What is the function of this protein?
Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins.
What are the official names of this protein?
Secreted RxLR effector protein 149.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host cytoplasm. Note=Localizes to bulk/chunk-like structures within the nucleus.
Protein: LV1B_BUTOC
Sequence: MISVQVIFIAFISIIAFSMVCGGNVFPNRELGILYGCKGYGNAFCDKVCKMHLARGGGRCGEPNPVMWACECIDIDEDNGYFLNALEKQCPLLKG
What is the function of this protein?
The monomer edited version, similar to alpha-toxins, may modulate voltage-gated sodium channels (Nav) and may block voltage-gated potassium channels (Kv).
What are the official names of this protein?
Lipolysis-activating peptide 1-beta chain, BotLVP1-beta, LVP1-beta.
What is the protein family that this protein belongs to?
Belongs to the long (3 C-C) scorpion toxin superfamily.
Protein: SUCC_GEOSW
Sequence: MNIHEYQAKEILRNYGVSVPNGRVAFTVEEAVEAAKELGSPVCVVKAQIHAGGRGKAGGVKVAKSLDEVRTYASELLGKVLVTHQTGPEGKEVKRLLIEEGCDIKKEYYIGLVVDRATSRVVLMGSEEGGTEIEEVAAKTPEKIFKEYIDPAVGLQAFQARRLAFNINIPKELVNQAVKFMMGLYQVFVDKDCSIAEINPLVVTGDGKVMALDAKLNFDSNALYRHKDILEYRDLDEEDPKEVEASKYDLNYIALDGNIGCMVNGAGLAMATMDIIKYYGGEPANFLDVGGGATAEKVTEAFKIILSDPNVKGIFVNIFGGIMKCDVIASGIVEATKQVGLNLPLVVRLEGTNVELGKKILQESGLNITAADSMADGAQKIVELVR
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: PKS1_CALOD
Sequence: MPPNTANKAAEIPPFEPIAIIGIGIRGPGGINSLTTLWDTLVERKSHCFPLAKDPRFHRRFNPDDFKALFDGIPDSENVLHSNLFDETPGLDRTYFSLSEREAAGMDVQQKLLLHVAHEALEDAGYSGVEDGSAFDPSTFGVYVATATDEVIQDPRDYDTDIYHLVRTERAFLSGQICFHFGLRGPSSSVDTVCSGSITAINDACRALATGDCRAAIAGGVHVVTPVSGPISFYSIKRAGFLDRTGQCKPFLHNGTGYSRSEGCGLVVMKRLSDAIREGDRIHGVIRGLCIRSMASPKFISQPNGVFQSVALAQAVKISGVDPAAISFVEAHGPGTAKGDLAEVSSLCTVLAQHRDVDNPLTVGSLKGNVGHAEAASGTHSLAKVIAMFQRRRIPPQADFHPSRLNPTLKPFFDKHPIRIIENEEDWNASHRIAIVGNFGASGNAGFMVVEEGSTFQPLEGRDVPKVSSPLPFVISAKDQATLVKLIHLYIDWLKQPSTFLTPLSDISYATTARRFTHPCMISVQADSHLDLAKKLQERPPMIDSSANRTSRQVAFCFSGQGGERVDPRNSTLYNFSASFTDAVDMCFRIVESESLIAEEDIAMLELFALEFGLMEMWKSWGINPVALAGHSFGEYVALVCAGVLTVRDALKLLGIRAALIRARCLDVPGKMAAVRLSVSDVNKCLEQQRSTHVELACVNSDNSVTLAGTPEDLESFRQELLKSYPAAGWHLLNNMTAAFHSRFVQPILADFTNACNEVKVHPSEMVVLSGLLGKMCPVGDAVLQQHDYLVRHCRETNRFGTAISDYQRRNVESETPQPDWIEIGSHSRIISFISLASDQLKFPSHGKTAADGWTTALDTLMRLYSAGHVVDFKDLHNDINPSAHHTDLPLYPFQFEPHVYPARREAKAISTTLASANEVELCPRVPSTELAPLLLNHVMAGYTLCPATTHVALLLAAAASSASSSQHEGRLAYKLFKLKVIAGFTNTTDGWLQVRRHLATSELEIISNDDNKIHITARAEVCKEQDMLESLSLYKPFILPFKSFKSLPTTDVLRKELAYSLFNHTVNYGAHGQVLDRVWIAEDGHQAWGYSTYPGGARTAEGVPTVLRDFSPMLIESTCQLIGFLMNTSMERKDGEAFVTDELGECSIALSKLYETKYVELYASFKMVDGGTAGLGNVFAFDDKGQLISAFRDVRMAKMKIYVLKRLIDRGRKPEQVVNTQHVAPEEVEEDNDANNDLEEKVISVLKAALRLSEIPRDKTLGELGLDSLTAIDVGVQLERLVPHRRDHLTIDPEGNLAALLQILRPAPSPKSLPTTSSTKEIKLTNGDLEVKAISTPPSLPITANGIPTANGVATTNVVPAVNGVTVNGVPKANGVPKANGVYTAKMPTEPATALIANLSPEMMEAISSNPEVVQHAPGRTPLLLIHDGGGTSFAYYSLGNLDRTVIGIHAPGLQEGKGMVNILHATNEYANIARQYLKQHCPGHSKLLIGGWSLGGTISITMAAMFPDLVAGVVTIDTTPPGVGGLTAEEAESVLLHPWSRSDGIHGLVRKQLEQNTRALFANPEYKTTIRNTTVNVPVYVICAKDPFRPPESLHLQDSSSQWLIDFKEPQVAEVMWKSLMGERLLGVQIIPGNHWTMFTPANAKTTTEALRRGLDVIEGWLNKAG
What is the function of this protein?
Non-reducing polyketide synthase that synthesizes the universal anthraquinone precursor atrochrysone carboxylic acid from malonyl-CoA (PubMed:35218274).  Produces a mixture of both 3R and 3S enantiomers with an excess of the 3R form (PubMed:35218274).
What are the official names of this protein?
Atrochrysone carboxylic acid synthase PKS1, ACAS, Non-reducing polyketide synthase 1.
Protein: RS3_CAMJJ
Sequence: MGQKVNPIGLRLGINRNWESRWFPTKANLVENIGEDYKIRAFLKRKLYYAGISQILVERTAKKLRVTVVAARPGIIIGKKGSDVDNLRKELQDLIGKDVNINIKEERKAGASAQLAAESVATQLEKRIAFRRAMKKVIQGAQKAGAKGIKVSVSGRLGGAEMARTEWYLEGRVPLHTLRAKIDYGFAEARTTYGNIGVKVWIFKGEVLHKGMQPEKTEESAPAKKPRRTRRGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CH60_CLONN
Sequence: MAKSILFGEESRRAMQAGVDKLANAVKVTLGPKGRNVVLDKKFGAPLITNDGVTIAKEIELEDMYENMGAQLVKEVATKTNDVAGDGTTTATLLAQAIIREGLKNVTAGANPMLIRKGIKLAVDTAVEQIKKSSKQVDGKEDIARVAAISAADPEIGKLIADAMEKVGNEGVITVEESNTMATELEVVEGMQFDRGYLSPYMVTDAEKMEAVLENPYILLTDKKISNIQEILPILEQIVQQGKKLLIIAEDIEGEALATLVVNKLRGTFTCVAVKAPGFGDRRKEMLRDIAILTGGEVISEEVGRELKDVTLDMLGTAESVKISKENTTIVNGKGNKEVIADRVGQIRRQIEETSSEFDKEKLQERLAKLAGGVAVVKVGAATETELKERKLRIEDALAATKAAVEEGIVAGGGTAYLRAIKEVEKLTDDNAEVRLGIAIIRRALEEPVRQIAANAGLEGSVIIDKIKNSEDGIGFDALEGEYTNMMQKGIVDPAKVTRSALQNAASVASTFLTTECVVAEIPEKNPMPAAPGMGGMGMDGMY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_SHEFN
Sequence: MARRPKGRFIDGIVLLDKDTGMSSNFALQRVKRFFNANKAGHTGALDPLATGMLPICLGEATKFSQHLLDSDKRYLVTAKLGQRTDTSDSDGEVVQTRPVNVTQALLDEKLAFFRGTTQQIPSMYSALKYQGQPLYKYAREGIEVPRESRPITVFELNFIKLEGDELTLDIHCSKGTYIRTIIDDLGEMLGCGAHVVMLRRTQVAEYPYEKMVTLAQLEALLEQAHRQDVAPQTLMDPLLLPMDTAVAKFAEINLPEAMLYYVMQGQAIQAAGLKPDELVRITIGDERRFVGMGIMNDDGLLAPKRLIVIHDNDAAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RL14_RAT
Sequence: MVFRRFVEVGRVAYISFGPHAGKLVAIVDVIDQNRALVDGPCTRVRRQAMPFKCMQLTDFILKFPHSARQKYVRKAWEKADINTKWAATRWAKKIDARERKAKMTDFDRFKVMKAKKMRNRIIKTEVKKLQRAALLKASPKKAAVAKAAIAAAAAAKAKVPAKKATGPGQKAAAQKASAQKAAGQKAAPPAKGQKGQKTPAQKAPAPKAAGKKA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JZ11F_CHIGU
Sequence: MKVSVLITLAVLGVMFVWASAAELEERGSDQRDSPAWLKSMERIFQSEERECRKMFGGCSVDSDCCAHLGCKPTLKYCAWDGTFGK
What is the function of this protein?
This toxin acts as a voltage-dependent gating-modifier (PubMed:25240294).  It inhibits the sodium conductance (IC(50)=124 nM) and slows the fast inactivation (EC(50)=1180 nM) of Nav1. 5/SCN5A (PubMed:17176080, PubMed:25240294).  It significantly shifts the activation to more depolarized voltages and decreases the deactivation of Nav1. 5 currents upon extreme depolarization, but only slightly affects voltage-dependence of steady-state inactivation (PubMed:17176080, PubMed:25240294).  In addition, this toxin causes an approximately five-fold decrease in the rate of recovery from inactivation and an approximately 1. 9-fold reduction in the closed-state inactivation rate (PubMed:25240294).  This toxin integrates the functions of site 3 toxins (alpha-scorpion toxins) with site 4 toxins (beta-scorpion and spider toxins) by targeting multiple sites on Nav1. 5 (PubMed:25240294).  Also shows inhibition of voltage-gated potassium channels (5 uM completely inhibits Kv2. 1/KCNB1, whereas 5 uM moderately inhibits Kv4. 2/KCND2 Kv4. 1/KCND1 channels) (PubMed:17176080).
What are the official names of this protein?
Kappa-theraphotoxin-Cg1a 6, Kappa-TRTX-Cg1a, Jingzhaotoxin-11.6, JZTX-11.6, Jingzhaotoxin-XI.6, JZTX-XI.6, Peptide F4-13.64.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 28 (Jztx-11) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPE_PSEMY
Sequence: MTSATIPAHAELILPAPAKLNLMLHILGRRADGYHQLQTLFQFLDHGDELGFSVRQDGEIRLHTPIDGVPHASNLIVRAAKRLQEASGTTLGADIWLDKRLPMGGGIGGGSSDAATTLLGLDHLWHTRLGEDRLAEIGLALGADVPVFVRGRAAFAEGVGELLTPVELEEPWFLVAVPQVFVSTAEVFGAPELTRDTPPIKVRSLLAGGGRNDCQPVVEKRYPEVRNALILLNKFVSARLTGTGACIFGSFPNRDDADKVARQLPGTLPSFVAQGRNISMLHRRLQALAKK
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ANMK_BURA4
Sequence: MPQRHPQPAHPADGIYFGLMSGTSMDGVDGVAVRFETGHAPVVLAEAFVGFAQSLRDALFALQQPGDNEIDRESLAANALVTRYAVCCHELQRTAGLSRDEIRAIGVHGQTVRHRPERGYTRQLNNPALLAELTQVDVIADFRSRDVAAGGHGAPLAPAFHATVFGAPGETRVVCNLGGISNITILPAEGGDVRGFDCGPANALLDEWATRHLGKPYDDGGKFAARGTVHAPLLDALLDEPYFAAPPPKSTGRDLFNPAWLDAKLAAFAQVAPQDVQATLTALTAVSVAREVATHASGCKALFVCGGGARNPVLLDALKQALHEAGVPASVDTTAALGVPPQQVEALAFAWLAYRFTARQPGNLATVTGAAGNRVLGALYPR
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: ATPD_YERPG
Sequence: MSEFVTVARPYAKAAFDFAVEHQAVERWQNMLAFTAQVTRNEQIAELLSGAVAPETMSTTFIAVCGDQLDEPAQNFIRVMAENGRLLVLPEVLQQFIQLRASLESTVDVEVSSARALNDEQLAKIAAAMEKRLSRKVKLNCKIDKSVMAGVVIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NRDR_RUEST
Sequence: MRCPFCGNVDTQVKDSRPAEDHVSIRRRRFCPACGGRFTTYERVQLRDLVVIKTNGKREDFDRDKLERSIRISMQKRPVDPERIDQMISGIVRRLESMGETDIPSKKIGEIVMEALARIDTVAYVRFASVYKNFQAADDFEDFVHELRPPAPPES
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PYRR_CLOP1
Sequence: MHLKASLLDENAIRRALTRLSHEIIEKNKGVEDIVLVGIKRRGYPLAERLSEFIEKFEGVKIPVASVDITLYRDDLTNVSDTPNLNDPKIDVDIRGKKVIIVDDVLYTCRTARAAIDAIMDQGRPEFIQLAVLVDRGHKELPIRADYVGKNIPTSKDEIIKVQIKEIDGTDSVEIYEN
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: VF335_IIV3
Sequence: MIDSPTLESFLVKSNLTINLSALVDRLIPLIFENQKLYKETGGYRSGSIVALKYNNIVEGEFKKHTSFKNACHIVMCHTLDKRKKKLIHIKITAIGTFQIVGISTCHVEKIIFKIFLLMEKLNKDSATPQPIYTYFSANPTANVQHNRFEIVIIPILFNHMLTLDPNLRKRIFSHSKVKIAENFIKNGFVSFIVPNDPAITIKKQFSYADFCNYPIQHVIWSAKSGKTAQYIAYDSYTTLLKDGQKTNAQDKKYLTLRLFSTGKVLVSGFNEVLIKNGVQKFLSVCDTF
What are the official names of this protein?
Uncharacterized protein 017R.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 335L family.
Protein: RL18_ANASK
Sequence: MAKHVTTREKRRARIRRKISGTELRPRLTIYKSLKHMYAQLVDDVAGKTLVSVATTSKSLKGELGDEDKTAAAKKVGEALAKAAKAKGIEQVVFDRNGFDYHGRVEAVAAAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.