PharMolix/UniProtQA huggingface dataset:
Protein: TYSY_DICNV
Sequence: MQTYLTLLETLLTTGVDKSDRTGVGTRSLFGYQMRFDLAAGFPLLTTKKMHFKSIVYELLWFLSGNTNIAYLNQNGVSIWDEWADKNGDLGPIYGKQWRNWAGRDQIHQVLTSLKTNPDSRRMLVSSWNVAQLEEMALPPCHVLFQFYVANGRLSCQLYQRSADVFLGVPFNIASYALLTMMMAQQADLELGDFVWTGGDVHLYRNHFAQAQEQLKRQPYPLPKMHIKRAKSIDDYVFEDFLLVDYRCHAAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_DINSH
Sequence: MVPTEKLAQITERFEYIEARMAAGAAGEDIAALGREYAELKPVVAEIAAYSRARADLAEAEAMLDDPEMRALAEEEIPALKARIPEMEQALRLALLPKDAADARPAMIEIRPGTGGEEAALFAGDLLRMYQRYAEAQGWRFQIVSESLTELGGIKEVIAHVSGSGVFAKLKYESGVHRVQRVPVTESGGRIHTSAATVAVLPEAEAVDIDIPASDIRIDTMRASGAGGQHVNTTDSAVRITHIPTGLVVTSSEKSQHRNRDIAMQVLRARLYDLERQRADAERSAARKGQVGSGDRSERIRTYNFPQGRMTDHRINLTLYKLDQVMQGDLDEVIAALAADDQARLLAEVEG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_PSYWF
Sequence: MQLSFIESCFHAFKDQSALVHNLTNDVAHNTVANVLLACRASPAMVHDIQEAPDFVCLSDALAINIGTLTQTRLNSMLATAKMAHSKGIPWVLDPVAVGATAFRQQACRQLLSLQPDVIRGNASEILALAGMSSQSRGIDSGDSVAAAHAAAEALTQYAKVVVVTGEIDWVTDGMNRWAINHGHPMMTQVTAIGCALTALIAGFVGANKKAMAQAAVTALCYYGQAAEHAMQIAQGPGSFYIHFLDSLYALQATDVSQQARVTLYE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: DTWD1_MOUSE
Sequence: MALSPSVVPQESKEDNANCVETKPSQTTSIASEDPLQNLCLASQEVLRKAQQSGRSRCRQCGGSRMFYCYTCCVPVGNVPTEQIPCVQLPLKIDIIKHPNETDGKSTAVHAKLLAPDSVNIYTYPCIPEYEGKDHEVVLVFPGPQSISIEDVSFHLQKRIESKGRNKADNLDVPPRKLKRTTDEEGWDLHESTRQGPELKRVVFIDSTWSQTNQIASDERLRELLQVELRTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHSAVQKEKYRGQYDNLLFFYSFMYRLIKNARGSGEKAKPQLVQ
What is the function of this protein?
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
What are the official names of this protein?
tRNA-uridine aminocarboxypropyltransferase 1, DTW domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. DTWD1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KAD2_ASPFU
Sequence: MAPITEEVVHGLKDMIEKLENRVQELEARLGGESKPKSIAEQMRIVLMGPPGAGKGTQAPRLKEKYCVCHLATGDMLRSQVAKKTELGKEAKKIMDQGGLVSDEIMVNMIKNELDTNSECKNGFILDGFPRTVAQAERLDDMLEARNQKLQHAIELQIDDALLVARITGRLVHPASGRSYHKIFNPPKNDMKDDVTGEPLIQRSDDNAETLKKRLSTYHAQTAPVVEYYKKTGIWRGIDASQEPGQVWKSLLGVFQK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: ARAG_YERPE
Sequence: MSAPHSALQAELDAAQSPYLAFRGIGKSFPGVLALDDISFTCQAGQIHALMGENGAGKSTLLKILSGNYTPTQGEIHIKGKAVNFTNTTDALDAGVAIIYQELHLVPEMTVAENIYLGQLPTKMGMVDRKLLRYESRIQLSHLGLDIDPDTPLKYLSIGQWQMVEIAKALARNAKIIAFDEPTSSLSAREIEQLFRVIRELRAEGRVILYVSHRMEEIFALSDAITVFKDGRYVRTFDDMTQVNNASLVQAMVGRNLGDIYGYQPREIGSERLTLQAVKAIGVASPISLTVHQGEIVGLFGLVGAGRSELLKGLFGDTKLTSGKLLLDGQPLTIRSPIDAISAGIMLCPEDRKADGIIPVHSVQDNINISARRKTLTAGCLINNRWEADNALLRIQSLNIKTPGPQQLIMNLSGGNQQKAILGRWLSEDMKVILLDEPTRGIDVGAKHEIYNVIYQLAKQGIAVLFASSDLPEVLGLADRIVVMREGAISGELDHEYATEEQALSLAMLRTPNIATNTASAVA
What is the function of this protein?
Part of the ABC transporter complex AraFGH involved in arabinose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Arabinose import ATP-binding protein AraG.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ADHR_DROTE
Sequence: MFDLTGKHVCYVADCGGIALETSKVLMTKNIAKLAILQSTENPQAIAQLQSIKPSTQIFFWTYDVTMAREEMKKYFDEVMVQMDYIDVLINGATLCDENNIDATINTNLTGMMNTVATVLPYMDRQMGGSGGLIVNVTSVIGLDPSPVFCAYSASKFGVIGFTRSLADPLYYSQNGVAVMAVCCGPTRVFVDRELKAFLEYGQSFADRLRRAPCQSTSVCGQNIVNAIERSENGQIWIADKGGLELVKLHWYWHMADQFLHYMQSNDEEDQE
What are the official names of this protein?
Alcohol dehydrogenase-related 31 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MOB1A_DICDI
Sequence: MNIFGKKSQTFKPKKNIQEGSKQYHLKQYAEATLGSGNLKSAVSLPTGEDINEWLAVNTTDFFNQINMLYGTITEFCTGTDCPVMSAGPKYEYHWADGTTVKKAIKVSAPEYVDFLMTWVQSQLDDENIFPSKIGVPFPKNFQSIVKTIFKRLFRVYAHIYHSHFQKIVSLGEEAHLNTSLKHFIYFIQEFNLVDKKELGPLNELIESLMKNP
What are the official names of this protein?
MOB kinase activator-like 1 homolog A, Mps one binder kinase activator-like 1 homolog A.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
Protein: Y356_MYCMM
Sequence: MTELDEVDSLRSDGDSWTVTESVGATALGVAAARAVETAGANPLIRDEFAPILVSSAGPAWARLADPDIGWLDDDPHGQRLHRLGCDYQAVRTHFFDEYFAAAAGAGIEQAVILAAGLDCRAYRLNWPPEAVVFEIDQPKVLEYKAQILESHGVTAAATRHGVAVDLREDWPAALLRAGFDRDRPTAWLAEGLLPYLPGDAQDRLFEMITDLSAPRSRIAVESFTMNLTGNKQRWNRMRDRLGLDINVEALTYREPGRADAAEWLANHGWQVYSVSNREEMARLGRPVPEDLVDEAITTTLLRASLEISR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MMAR_0356.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: RM39_SCHPO
Sequence: MAKKNKARLLVKLLSTAGTGFFYVRSRPKAAPKLAFIKYDPKIHKRVLFEESKMK
What are the official names of this protein?
54S ribosomal protein L39, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1977_PECCP
Sequence: MSESCPCCSGLQYNACCQPYLTHAATAAEPAVLMRSRYTAYVKHDVDYLIATWHPDLQPEKWRASLAESCQNSQWLGLTILATSPGKTPDEGYVEFAARYISETDSQRTEVMRERSRFLRQHNRWYYIDGVHVQTGRNEPCPCDSGKKYKKCCGQ
What are the official names of this protein?
UPF0225 protein PC1_1977.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: RPOZ_PSYCK
Sequence: MARVTIEDCLDNVDNRFELVLVASKRARQLAKGIAEPLVDVDNDKPTVLALREIAAGKITRDILNQPEHNFATSSLDLALSGDHSF
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: SNF11_YEAST
Sequence: MSSEIAYSNTNTNTENENRNTGAGVDVNTNANANANATANATANATANATAELNLPTVDEQRQYKVQLLLHINSILLARVIQMNNSLQNNLQNNINNSNNNNIIRIQQLISQFLKRVHANLQCISQINQGVPSAKPLILTPPQLANQQQPPQDILSKLYLLLARVFEIW
What is the function of this protein?
Involved in transcriptional activation.  Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes.  It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
What are the official names of this protein?
Transcription regulatory protein SNF11, SWI/SNF complex component SNF11.
What are the subcellular locations of this protein?
Nucleus.
Protein: IWS1_CRYNJ
Sequence: MSSPALDTIHDQTGEQDLHQEVQAQEHLPVEPTPEVQEEPESDHQDDDEQPEAQVLEQEQEQVAEQERLQDQEDQDQGAELVSQQPTAEEQEETRDELYNEVFGNQGSEASDLSDDEDVRMDEGEKYVPATATSAAKIPKFKKSKRDDEDEDEDEDEDEDDGGERRRKKKKRAERRRQRQEEEDEDEAPVLDEATQRRLALEERIDAIGKKPKAIRRKKKGDDDVDIVDSYHDDICARLRDRMIAAADKDEAANRIKMPGTAKLAMLDEVMGVLRNTTLWQSIVDNGVLEAVKRWLEPLPDKSLPSVGIQKAIFEVLPKMDLDTTTLKECRLGPIVLFYTKTKRVTPAINRQADALVQAWSRPIIKRPANYRSRYIESQNEVEQSQGGGGTGGGYSQSQRGPGERKFKRFDVKKALEENAHRKGARLQIVQDVQYTVAPEPKTHHHAEEMQHVSRIQQDNKKFNRFARQVKTKKH
What is the function of this protein?
Transcription factor involved in RNA polymerase II transcription regulation.  May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity).
What are the official names of this protein?
Transcription factor IWS1.
What is the protein family that this protein belongs to?
Belongs to the IWS1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBL2_POLNA
Sequence: MDQSNRYADLSLKEEDLIAGGRHILVAYKMKPKAGHGYLEAAAHFAAESSTGTNVEVSTTDEFTKGVDALVYLIDEATEEMRIAFPMDLFDRNILDGRMMIVSFLTLVIGNNQGMGDIQHAKIYDFFMPPRAIQLFDGPSKDISDMWRILGRPVKDGGYIAGTIIKPKLGLRPEPFAQAAYQFWLGGDFIKNDEPQGNQTFAPMNKVMPLVHDAMKRAMDETGEAKLFSANITADDHYEMLARGDYILRTFGPDADKVAFLVDGYVGGPGMITTARRAFPNQYLHYHRAGHGAVTSPSAKRGYDAYVLAKMSRLQGASGIHVGTMGYGKMEGTHDDRAIAYIIERDSYTGPAYHQEWYGMKPTTPIISGGMNALRLPGFFENLGHGNVINTSGGGAYGHIDSPAAGATSLRQAYECWKAKADPIEWAKEHPEFARAFASFPGDADMLFPGWRDKLASHR
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase, RuBisCO.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type II subfamily.
Protein: TRPA_NITEU
Sequence: MNRIQSVFSQLKSQNRAALIPFITAGDPDATTTVALMHRLTQAGVDLIELGVPFSDPMADGPTIQRSSERALKHHISLKDVFSMVAEFRKTNQSTPVVLMGYANPIEAMGYKDFVQTAGHAGVDGVLVVDYPPEECTEWVRYLKEQNIDPIFLLSPTTPESRIRRVAELARGYVYYVSLKGVTGASHLDLHEVGDKLSQLRSYINIPIGVGFGIRDEQTARRIAEQADAVVIGSRIVEEIEHSPAADLLANVGALVESLRRAIDAKSDHSSITEK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: HDA_KLEP3
Sequence: MPLYLPDDETFASFWPGDNPSLLAALQNVLRQEHSGYIYIWSREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLEGMEQLALVCIDNIECVAGDEPWEMAIFNLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFEMPEDVCRFLLKRLDREMRSLFMTLDQLDHASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: HIS2_BACC3
Sequence: MENTFKLLFETIGERKRNPLPESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDKEELVKEMVDVLYHCFVLLAEKNISLEDIMAEVTERNGKLSRVGDRREIDTL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCR4_CANAL
Sequence: MNITNKFQHTPIQGQPQSNLQAQQILLSQLHQGQAQQQQQQQQQQQQQQQSSAGVLGSGFQPSDNFGESLNQNIYQNNYQRAQPSLQQQFFPQFQQSQQQPSQQANNASQLQQPYQPAQQMVRQTSHFQQQQQQQPSSQQFYSQQQASVLQQQQQQQIQLQSAHQQQSSLLNMNSINVDNPNSVYWQHQQQLCQISRGSNVPHYYARQYASNSRKAKNPYSEVKSVGLVEATRSMVASLEDEEEKKKKPINYQGTPTTSAALLHNKKSTQDIFEDDSMEEQRMRLKTQGKQLWCQLDLSGQGLVNISSKLFHYDFLESLYLSNNKLNSIPSSISKLRNLRTLDLSHNRINELPEELGLCFNLRYLFLFDNNIKTLPYSFGNMIELLFIGIEGNPLEPSIANLIAEKGTKELIATLRDQTTVKRTPKPRCWLTLEDDGEVVDSDEVYKVEPESSDNFTVLSYNTLCQHYATPKMYKFTPSWALQWDYRKNLLEKEVLNYNTDIVCMQEVETKTFQEFWLPVMTANGYKGYFFSKTRSKTMSETDSKKVDGCATFFKNDKFSLIHKQNFEYNSVCMGSDKYKKTKDLFNRFMNKDNIALISYLQHKESGEKIAVVNTHLHWDPAFNDVKALQVGILLEELQGIIKKYRHTNSNEDIKNSSIVVCGDFNSVKDSAVYQLFSTGASKGHEDMNGRDYGKFTEDGFHHPFKLKSAYEAVGELPFTNLTPAFTDNIDYIWYSTPTLQVKGLLGGVDEEYTSHSIGFPDANFPSDHVPILAKFQLKKGKKNHSV
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).  Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
What are the official names of this protein?
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4, Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MECA_STAHJ
Sequence: MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPLWIQVHAFEKGVEVTISKSKNEEAMNMSDEDANEQFEEQVNELLANTLENEESIEDLFEQRAQQQKHSHKSEQKQTKQRPNIRTVIVKFDDLEQVISYAYHHNLSTDEFEDLLYMNDNKYYYAIHFDESVSQEMINDSYSQMLEFAYPTDKTEVYLNDYAKIIMSHNVTAQVRRYFPDTVE
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: GFD2_YEAST
Sequence: MQVQKMVRDNSNNGSDKSVHWERRNNNGAGPRYRSRSGNTGALATKLSNGTLSVRGLVKDRTGSGKIAGCVEAFLDARTQLNTPWDRAKCNWLDQIDYYVQLRKTAFSKELDQLRKPMIDAYVAEMRQKFDASYGQSRAQLEAKLAQVDSEWHMVHGDVHAKLEKLVEERRFLKRLSDTIVPPRSKRSQRLSPLTKEDRANCICPQPKGMSDTAWFEAIQKKMLGMNGTIKLLETEQKLLADEKNSVRKTFWPMVEAHSRSNEFAYLEKCIRLMASQRAICFCLDIEAFETNQNVITEIGISIYDPRENMVPSMVPITKNYHLIIEESLELRNQKWVCDYKDCYLLGESYVLSLKECVHFIQSLINYYLVPVTEEDKTWSRAFVGHHVSGDLKWLETIGVKFPGRGYEGHLDHTLLLAETPGDLDVFILDTEQFYRKSYGEKGSSLGKILRLFEIPHAFLHNAGNDAYYTLHLFMKFCDVNFRKISGMDDVLKVMGQVKVWGERDVREPKVVPMSYAISIEEAVKNRTYRKGVKSSRKERVCQTEFGGLTYFGTAKDAFTSTLPTH
What is the function of this protein?
High-copy suppressor of DBP5 mutation.
What are the official names of this protein?
Good for full DBP5 activity protein 2.
Protein: XYLA_BACSW
Sequence: MPYFDNISTIAYEGPASKNPLAFKFYNPEEKVGDKTMEEHLRFSVAYWHTFTGDGSDPFGAGNMIRPWNKYSGMDLAKARVEAAFEFFEKLNIPFFCFHDVDIAPEGETLKETYKNLDIIVDMIEEYMKTSKTKLLWNTANLFTHPRFVHGAATSCNADVFAYAAAKVKKGLEIAKRLGAENYVFWGGREGYETLLNTDMKLELDNLARFLHMAVDYAKEIGFDGQFLIEPKPKEPTKHQYDFDVATALAFLQTYGLKDYFKFNIEANHATLAGHTFEHELRVARIHGMLGSVDANQGDMLLGWDTDEFPTDLYSTTLAMYEILKNGGLGRGGLNFDAKVRRGSFEPEDLFYAHIAGMDSFAVGLKVAHRLIEDRVFDEFIEERYKSYTEGIGREIVEGTVDFHKLEAHALQLGEIQNQSGRQERLKTLLNQYLLEVCAAR
What is the function of this protein?
Exhibits xylose isomerase activity.
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_STAAE
Sequence: MAKKKSPGTLAENRKARHDYNIEDTIEAGIVLQGTEIKSIRRGSANLKDSYAQVKNGEMYLNNMHIAPYEEGNRFNHDPLRSRKLLLHKREIIKLGDQTREIGYSIVPLKLYLKHGHCKVLLGVARGKKKYDKRQALKEKAVKRDVARDMKARY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SSU72_SCHPO
Sequence: MAPKTNLQISVICASNQNRSMEAHNVLKNAGYQVDSFGTGSAVRLPGPSIDKPNIYQFGYPYDEIYKELEAQDSRLYTANGLLKMLDRNRRIKRAPCRWQDQDSIYNIVITCEERCYDAICEDLYRRGETLNRPVYLINVDIKDNHEEASVGGKAILDLVNKLTEAQDKLEELFPSIMADFQSNHPKLPVLYTIHFF
What is the function of this protein?
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.  Ssu72 is required for 3'-end formation of snoRNAs (By similarity).
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase ssu72, CTD phosphatase ssu72, Suppressor of SUA7 protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the SSU72 phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PYRD_LEGPH
Sequence: MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGTVTPKGQAGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQGDYFAELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATNTTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGPELIHDIVSGLNAI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DXR2_BACCR
Sequence: MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQSVSGNTKIVYGSEGLLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGENEKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKESIIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMDQERFRCLRFAYEAGKAGGSMPAVMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase 2, DXP reductoisomerase 2, 1-deoxyxylulose-5-phosphate reductoisomerase 2, 2-C-methyl-D-erythritol 4-phosphate synthase 2.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: AROA_SHISS
Sequence: MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQAA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT24_DROME
Sequence: MNFLKKLLPQVATEVQQLSRSGFHTSSVCCRVQSGRYRITTKRNRPLTYEMANPPHFIGHRKSWNSWNTSTMKDALRPSQTAIEDVFIRKFVTGTWHALVCSEVIIKRQHNTIRIAALIRQAITPRKMYFLIGYTEELLSYWMQCPVTLELQTVGDKKDVVFKYI
What are the official names of this protein?
28S ribosomal protein S24, mitochondrial, MRP-S24, S24mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HISX_NITMU
Sequence: MISIKRLSSADTEFDKALSELLAFENTQDAKLEAAVADILAKIRTEGDKALLEYTLRFDRVDAKSAADLELPRNRLQQALHNLPGEQRNALEQAAERVRVYHEKQLTQSWSYVEPDGTHLGQKITPLDRAGLYVPGGKAAYPSSVLMNAIPAKVAGVGELVMVTPTPQGEVNDLVLAAAAICEVDRVFTIGGAQAVGALAYGTPTVPRVDKIVGPGNAYVATAKRHVFGVVGIDMLAGPSEILIICDGKTNPDWIAMDMFSQAEHDELAQAILLSPDLHFIETVAASIVRQLETMPRKEIIRTSLENRSALIQVHDLEEACEIANSIAPEHLELSVEQPEKWVEKIRHAGAIFLGRHTSEALGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSIIQVSGQGSAKLGAIASILAQGEGLQAHAMSAEYRYTKKIALGKN
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: DPO42_MYCBO
Sequence: MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPRKVVTCASYEARAYGVRAGMPLRTAARRCPEATFLPSNPAAYNAASEEVVALLRDLGYPVEVWGWDEAYLAVAPGTPDDPIEVAEEIRKVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRTVEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLLAKGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVVASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFELDRPVRLLGVRLELA
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity).
What are the official names of this protein?
DNA polymerase IV 2, Pol IV 2.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESFL6_ARATH
Sequence: MSPSHFAILFIIVISLVPLHGYANGQGFDANKLGSSVCHLGKCPKHREEVCYCCFNDRSRCYRSLYKCVAVCNRLVH
What are the official names of this protein?
EMBRYO SURROUNDING FACTOR 1-like protein 6.
What is the protein family that this protein belongs to?
Belongs to the MEG family.