PharMolix/UniProtQA huggingface dataset:
Protein: RS10B_MOUSE
Sequence: MVKEKKKADKKGDKSARSPSSISDNPEASKQDSNASKQEVAPSAVVPVVETPLKQAPKRDSVQMEQSEEETQYEEPILTKLIVESYEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRNGFGMFKCGTQPVSYIGHWCHGKRHGKGSIYYNQEGTSWYEGDWVYNIKKGWGIRCYKSGNIYEGQWENNMRHGEGRMRWLTTNEEYTGHWEKGIQNGFGTHTWFLKRIPNSQYPLRNEYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQGRGRMTFKNGHVYEGLFSNDHIAQFFETEMDYSQSLDRWSDASQRSRQPRGSSVSAVREPETLRKLDGSESRSVLGTSIELDLTLLLDMYPEESQEEEKKQVEYAVLRNITELRRIYCFYSGLGCDHSLDNTFLMTKLHFWRFLKDCRFHHHNITLADMDRVLSVYNGIPIEEIHSPFRTILLRTFLNYLLQLAYYIHHKEFQNRSPSLFLCFTKLMSENIHPHACQVKGHLFSEQQRTLYSMNYIDKCWEIYTAYCRPNEAPPYELTMKMRYFLWMLKDFRMINKDLTATKFMTVIAEDNPFVYDGTDSNFELELVFLEFFEALLCFSLCCMFDQMTRSYLKVPYDDITTNRYGSTQTILNQSIHRSPSAITSHDSEVHFSSTKSSLDKIGALPDGKIRQSEPKLKKSLSEDKVSKMNFKTQGRGLVFMSPQGEKYEKPKDEQKEKLNIWVNNLYVFFVSVLFSAYKREEMLKEKVKENQLQEAELAQQRQIENEELEARLNILREEEARKQDFELDITVLKEPSEIPASQPLTPSPPKEDLASIQTSKASPGKKKKK
What is the function of this protein?
May function as part of the axonemal radial spoke complex 3 (RS3) (Probable).  Radial spoke complexes are important for ciliary motility (PubMed:34871179).
What are the official names of this protein?
Radial spoke head 10 homolog B.
Protein: GLTK_ECOL6
Sequence: MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA
What is the function of this protein?
Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Glutamate/aspartate import permease protein GltK.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTH_BUCAP
Sequence: MIVGLSNPKKKYHKTRHNVGSWYIYSLAKNYLSILKEEKKFFGFTGCLNIKSNFIRLLIPDIFMNINGFSVHRMASFYNISLNQILIVHDDLDLAPGIIKYKYSYGHSGHNGLRHIIKEFNTKVNFYRLRIGIGRPKNKNEISSFVLSIPDFKEMKLIKKSISYAIKENFTLLNLIQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLHC_CUPMC
Sequence: MTTRKSVLREVEEFRLAVELVELGARLQVLESEVAISRDRLTRLYKELRGVSPPKGQLPSSPEWFLTWRPNVHASLFLSAYRFLMAQGKQSRIRCIVSAYRLYVEHISLIGEDLTLSFTRAWTMLRFLDSGTLVSSTCKCCGGSFVRHKYDLQTNFVCGLCAPPPRAAKGKKLATSAEPFVVPEDLQQTISIEPAAMNRPKDAPLRRMGSLKP
What is the function of this protein?
Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhC.
What is the protein family that this protein belongs to?
Belongs to the FlhC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_MYCSK
Sequence: MSAKSTPDAGPQEQATEAEAELRHRWQALADEVRDHQFRYYVRDAPVISDADFDKLFQQLEALEAEHPELRAPDSPTQLVGGAGFATDFTPAEHLERMLSLDDVFNVDELTAWSSRVRAEVGDDAAYLCELKVDGLALALVYRDGRLERAATRGDGRVGEDVTLNARTLDDVPERLTPSDEFPHPAVLEVRGEVFFRVADFEALNAGLVAEGKPPFANPRNSAAGSLRQKNPAVTARRPLRMVCHGIGYTEGFSPTSLHEAYGALRAWGLPVSDHTTRVQGMDAVRERIAYWGEHRHDIEHEIDGVVVKLDQIALQRRLGATSRAPRWAVAYKYPPEEAQTKLLDIRVNVGRTGRVTPFAYMEPVKVAGSTVGLATLHNASEVKRKGVLIGDTVVIRKAGDVIPEVLGPVVDLRDGTEREFVMPTHCPECGTELAPAKEGDADIRCPNSRTCPAQLRERVFHVAGRGAFDIEGLGYEAAIALLQAGVITDEGDLFTLTEDDLLRTELFTTKGGAVSANGRRLLANLGKAKAQPLWRVLVALSIRHVGPTAARALATEFGSLDAIIEASEDQLAAVEGVGPTIAAAVKEWFTVDWHCAIVEKWRAAGVRMADERDASIARTLEGLSIVVTGSLAGFSRDEAKEAIIARGGKAAGSVSKKTAYVVAGDSPGSKYDKAIDLGVPVLDEDGFRNLLENGPQAPEG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL19_KOCRD
Sequence: MNILDQLDAKSLRDDVPDFRPGDTLNVHVNIVEGNRSRVQVFKGFVMGRQGSGVRETFTVRKVSFGVGVERTFPVHSPIIDKIELVSRGDVRRAKLYYMRDRHGKAARIREKRESSASSK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ZNUC_ACIAD
Sequence: MQISPIAPELIRLENIYVHRDERDILKNIDFSLHQNEIVTLIGPNGAGKSTLIKILLGIIFPNKGKVIAKKKLKMAYVPQKFNPSHSLPLRVCDLLDLEKCSATLREEIIQDTGISKLQTAKVQQLSGGERQRVLLARALLRQPDILVLDEPMQGLDIQSEAELYEYVRSLPERYGCAILMVSHDLQWVMQGTQRVVCLNKHICCSGLPESVQQHPEYLAIFGGQRVPYQHHHDHCAHGDHVEQCNHIDHPHIHPEPEA
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YCEH_ECOLU
Sequence: MKYQLTALEARVIGCLLEKQVTTPEQYPLSVNGVVTACNQKTNREPVMNLSESEVQEQLDNLVKRHYLRTVSGFGNRVTKYEQRFCNSEFGDLKLSAAEVALITTLLLRGAQTPGELRSRAARMYEFSDMAEVESTLEQLANREDGPFVVRLAREPGKRESRYMHLFSGEVEDQPAVMDMSNAVDGDLQARVEALEIEVAELKQRLDSLLAHLGD
What are the official names of this protein?
UPF0502 protein YceH.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: MZT2_MOUSE
Sequence: MAAAAAAAGGAALAVSTGLETATLQKLALRRKKVLGAEEMELYELAQAAGAAIDPDVFKILVDLLNLNVAPLAVFQMLKSMCAGQRLASDPQDSVPISLSTSTSETRGRNRGGPILGNVTISAERGSRERPIQRMPRQPSATRLPKVGGSGKSNSRSSP
What are the official names of this protein?
Mitotic-spindle organizing protein 2, Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B.
What is the protein family that this protein belongs to?
Belongs to the MOZART2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
Protein: CCA_CUPMC
Sequence: MQVYAVGGAVRDQLLGKPSQDRDYVVVGATPADMEAAGFKPVGKDFPVFLHPHTKAEYALARTERKTAVGYKGFAFYTGADVTLEEDLVRRDLTINAMAQAVDEHDNLVGPVIDPYGGQKDLAARKFRHVSDAFAEDPVRILRVARFAARFHEFTVAPETVALMRKIVDAGEVDALVPERVWQELSRGLMEAKPSRMFDVLRECGALAHLLPELDRLWGVPQRPEYHPEVDTGVHVMMVIDYAASVGASLPVRFAAMAHDLGKGTTPEDMLPRHIGHEQRGVKLLEAICQRLRVPNDCRELALVVAREHGNIHRSTEFGAAALTRLVERCDALRKPERFAEALLACEADARGRLGFADKDYPQADRLLAARDAAASVDAGAIAKACGDKVDQIKDRVHKARVAAVAQRLGMAEE
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: CYB_SORTU
Sequence: MTNLRKTHPLMKIVNSSFIDLPAPSNISLWWNFGSLLGVCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYMYLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSDLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAGVHLLFLHEAGSNNPSGLSSDADKIPFHPYYTIKDILGVLLLILALTSLVLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAVVPFLHTSKQRSMMFRPFSQCLFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFLLILVIMPITSLFENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: T2R30_PANTR
Sequence: MITFLPIIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITVYNVWAVTNHFSSWLATSLSMFYLLKIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETIWTKEYEGNMTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFLSMIISVCNLGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVLWHVRYWVKDRSLRLHRFTRAALCKG
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 30, Taste receptor type 2 member 47, T2R47.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PUR7_ACIBC
Sequence: MLKQTLLYTGKAKSVYETDNADHLILVFRDDASAFNGEKIEQLDRKGKVNNRFNAFIMEKLAEAGIETHFEKLLSPTEVLVKKLQMIPVECVIRNYAAGSLCRRLGVEEGKELTPPTFELFYKDDGLGDPMVNESQAIALGWATAEQLEQMKVLTYKVNDVLKALFAEGNMILVDFKLEFGVFHDRIVLGDEFSPDGCRLWDKDTKKKLDKDRFRQGLGGVVEAYEEVAARLGVDLSDI
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: Y535_TREPA
Sequence: MRESAEAAGETLVKEAEGSVVEAQEQAWHEACARIDAQRREACGQLERELSVLEEDVERFEAFLDGFFFG
What are the official names of this protein?
Uncharacterized protein TP_0535.
Protein: SYM_STAAW
Sequence: MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEKAQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYLGEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDRLLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDALVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHGWILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDLANDLGNLVNRTISMVNKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVALSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPKEIFEQLNINNPQFMEFSSLEQYGVLTESIMVTGQPKPIFPRLDSEAEIAYIKESMQPPATEEEKEEIPSKPQIDIKDFDKVEIKAATIINAEHVKKSDKLLKIQVDLDSEQRQIVSGIAKFYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFUA_XANC8
Sequence: MIQISDKAQTYFRKLIEREGVPGMGVRLSAVDAGTPRADAKLEFAEPADLSGDEWAIDCDGFTLYVVAASVPWMDGAEIDYVTQSTGNQQLTIKAPKIKGEAPAESASMVERVRWVVENEINPQLASHGGRVAVQEVSAEGVVLLRFGGGCHGCGMADVTLKQGIEKTLMGRLPGVIAVRDATDHATGDAPYIPRDSAA
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: GTAF_DICDI
Sequence: MEFQEALKYIPSNSICSNPNYKLIWKKIQQYSYEVNSSSSLILSDISSSSYDLSGIFEKSLMIFLMIENFTTQYSNQSYLYRFLNEPPINNNNNNTKSEFQQIITDPSNKESLKSLLQFSKTINISKIFENNTQPIIISPPQQSQQPPPPTSGNNFFSILSSNINTINNNSNNNNNNNNCKSYKKQQTSKGSATASTNTTTDIYDEQQMKLQQLQQQYYQQQLNELQQINQQISQKVNLLQQTTPTTTNTSTTATTTTIPPSPSNTTTTTTNNNNNNIPQQTSISTASTSIKIISEDGVSNNKRKRRPRAPAPFLDSLYCHSCGETQTSQWRRGPDGCKSLCNACGIRFANIVSKEKALAVKEKNISINMLLNESSNQQQQQQQQQQQQQIIQQQQIIQQQQQKDDHLPLSRPSSFSSQSNSQQDDSLPLSRPSSFSSQSSSSSSSFLSSLLSSSSPPIPSTTTTTTTTTTTTSPTISSESLNFSSATNTPTNLSPNLQSINHNDKLINNNNNNNTALEGFPPTFNINNYNNNNNIDKLSSSKDSTENNGYNYYSSYNNYNISEYVPSPAYQNSRMTNVGIGSFKRKLSNEDQLNGLSAIVTASEQLFFGISNDVNQGSNVKL
What are the official names of this protein?
GATA zinc finger domain-containing protein 6.
Protein: IF2_BIFLD
Sequence: MAKPRVYELAKVLNVDSKTVLEKLKDMGEFVKSASSTIEPPVARRLKAEFAKDNAKGDSKPVQQRRPAAPSAPASTSSSAPTPAAPARQASPASAHQQAPTPGAPTPRPQGGARPGMPTPGRHGQNDNRENGRDNREGRENGRQSRPNDRRNNDRRNNQGRPNNGQPVQHQNNRGNASAPRPHAQGGAGANGGNAASNAIPRPHAQGPRPGNNPFSRKQGMHTPTPGDIPRPHPMARPTADNGRGGRPGRPGQGQGQGRGFRGGRPGQGGQGGPRPGQWGHNRPGQGGGSQGAGQGGARGGFRGGQGGGNNFQGGGAPSNGPARGGGRGGRGGAAGAFGRQGGKSSKARKNRLAKRHEYEELKAPTIGGVRIPNGNGQTIRLRQGASLADLAEKINVNQAALVTVLFHLGQMATATQSLDEETFQILGEEIGWNIQLVSAEEEDKELLQQFDINLDEEELQDDEDLKPRPPVVTVMGHVDHGKTRLLDTIRKTNVIAREAGGITQRIGAYQVTVNLEGEPRKITFLDTPGHEAFTAMRARGAELTDVAILVVAADDGVMPQTVEAINHAQAAKVPIVVAVNKIDVPGANPEKVRGQLTEFGLVPEEYGGDTMFVDISAKQNLHVDKLLEAVLLTADAELDLRANPDMDARGATVEARLDKGRGAVATVLVQQGTLHVGDAIVAGTSYGRVRAMLDENGQPMEAAGPSTPVQVLGLTSVPTAGDLFLVASDDRAARQIAEKRQATERAAQLAKRRKVVSLEDFKKKFAESEIDMLNIVIKGDSSGSVEALEDSLMKIEVSDEVGIQVIHRGVGAITQNDVNLATVDKAVIIGFNVRPNRQVADLAEREGVEIKYYSVIYRAIEDIEASLKGMLKPEYEEVVTSHSEIREIFRSSKFGNIAGVMVQDGEVKRGTKCRILRNGVATVNDLEISSLRRFKDDVQSVKEGYEAGINLGTFNDIELGDIIETFEMREVERK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCL9_PIG
Sequence: PMGMTQPLSHSNQMPSPNAMGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGNFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFAVLG
What is the function of this protein?
Involved in signal transduction through the Wnt pathway.  Promotes beta-catenin's transcriptional activity (By similarity).
What are the official names of this protein?
B-cell CLL/lymphoma 9 protein, B-cell lymphoma 9 protein, Bcl-9.
What is the protein family that this protein belongs to?
Belongs to the BCL9 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IMA8_BOVIN
Sequence: MPTLDAPEERLRKFKYRGKDASARRQQRIAVSLELRKAKKDEQALKRRNITDVSLDPSDQQTKGVSLTLQEIISGVNASDPELCFQATQAARKMLSREKNPPLKLIVDAGLIPRLVELLKSSLHPRLQFEAAWALTNIASGASELTRAVVVGGAIQPLVELLSSPHMTVCEQAVWALGNIAGDGPEFRDNVIASDAIPHLLTLVSSSIPVPFLRNIAWTLSNLCRNKNPYPSDHAVKQMLPALFYLLGHPDREVLSDTCWALSYLTDGCDARIGQVVDTGVLPRLVELMSSSELNILTPSLRTVGNIVTGTDHQTQLALDAGILGVLPQLLTHPRPSIQKEAAWALSNVAAGPRQHIQRLIACGALPPLVAVLKNGEFKVQKEAVWTVANFTTGGSVEQLIQLVQAGVLEPLINLLTIPDNKMVIIILDVLFFILQAAEKISQKENMCLLIEGLGGLDRIEALQLHENHQVALTALNIIERHFSEEEETVTAFRARDQDHKFLKDLTNTYHCCTTPKPGPRP
What is the function of this protein?
Functions in nuclear protein import.
What are the official names of this protein?
Importin subunit alpha-8, Karyopherin subunit alpha-7.
What is the protein family that this protein belongs to?
Belongs to the importin alpha family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLYA_CHLSY
Sequence: MLEHLRATDPIIADLIEREAQRQRQGLELIASENYTSLAVMEAQGSVLTNKYAEGLPGRRYYGGCEFVDAIEQLAIERACQLFGTSHANVQPHSGAQANIAVFTALLQPGDTILGMRLDHGGHLTHGSPVNFSGKWYNVHFYGVDAQTGQIDYDDLASKARAIRPKLITSGASAYPRIIDFARMRQIADEVGALLMADIAHIAGLVAAGEHPSPVGHAHVITTTTHKTLRGPRGGLILMGDDFAKQLNSSVFPGTQGGPLMHVIAGKAVAFGEALRPEFRQYAAQIRRNARALAEGLMAQGLTLVSGGTDNHLMLVDLRSTGLTGAQAQRALDKAAITVNKNAIPDDPQPPMKTSGIRIGTPAVTTRGMREPEMAQIAAWIGEVLMYPDDEARLNRIAGEVADLCRHFPVPADMVQVRG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_ECO27
Sequence: MAKTLYEKLFDAHVVYEAENETPLLYIDRHLVHEVTSPQAFDGLRAHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGKDFDDAVAYWKTLQTDEGATFDTVVTLQAEEMSPQVTWGTNPGQVISVNDNIPDPASFADPVERASAEKALAYMGLKPGIPLTEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: FTSW_GEOMG
Sequence: MNLNFKLNLKEIERYDLVILLMAVALTCFGVVMVYSASSVMATKKFHDGFYFLKRQGIYAILGCAAMIVAMRIDYRQWREYAVPILLGCLLLLLLVFIPGIGGAAKGASRWIRFPGFNLQPSELAKIALIMYMAYSLDKKQEKVKFFSTGFAPYMVLLAILLAILLKQHDLGSALTMGGVAILMLFAAGTRPRYILGMVVLTLPFLYFLVMNVDYRRRRILAYLNPWEDPTNTGFQIIQSWLAFGNGGIIGQGLGEGKQKMFFLPEAHTDFILSVVGEELGLIGVIVIAAMFLMLVLRGVRVALMAQDPFGRFLAFGIVTLLGIQAFVNMGVVTGLLPTKGLALPFISYGGSSLIVTLFAVGILLNVSTRMKGTP
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell division.
What are the official names of this protein?
Probable peptidoglycan glycosyltransferase FtsW, PGT, Cell division protein FtsW, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. FtsW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Protein: 5HT2B_MOUSE
Sequence: MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1426253).  Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:1426253, PubMed:16940156).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and downstream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity).  Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity (PubMed:16940156, PubMed:18337424).  May play a role in the perception of pain (PubMed:21273425).  Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162).  Required for normal proliferation of embryonic cardiac myocytes and normal heart development (PubMed:10944220, PubMed:11413089).  Protects cardiomyocytes against apoptosis (PubMed:12738797).  Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (PubMed:12244304).  Plays a role in vasoconstriction (PubMed:12244304, PubMed:23346101).  Required for normal osteoblast function and proliferation, and for maintaining normal bone density (PubMed:17846081).  Required for normal proliferation of the interstitial cells of Cajal in the intestine (PubMed:19941613).
What are the official names of this protein?
5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, 5-HT-2F, NP75 protein, Serotonin receptor 2B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Synapse, synaptosome.
Protein: PRIB_ACTP2
Sequence: MNQRKLASNSPIDNCLILSGSVASTVKQSQNPLGVPNYRFWLEHRSIQTEVNLERQAWCKIQVILNGNQFSLITQQIKLGDKIRVYGFIHTHKDYNGLSQLVVHAEHIEFIDQEKPNGTLFPSS
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: ADD_ECO7I
Sequence: MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARHGLHYVELRFSPGYMAMAHQLPVAGVVEAVIDGVCEGCRTFGVQAKLIGIMSRTFGEAACQQELEAFLAHRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVAELAAHPLKMFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.