PharMolix/UniProtQA huggingface dataset:
Protein: UBIC_CHRSD
Sequence: MSPDRFPGWPHWLPIAAQRPRMSPDWWPWVASRDSLTARLRIASPRPFSVRLLTQGVTRPRLDEAQALGLPHRTHVWHREVLLRLGNASWVAARSVAPLEGLSGARLCTLGERSLGSWLFRQPNLERGPIEAIRAPAMTGLDAWRGDAGPWGRRSLLRVGRTRILVQEFFLAAMAADLSLPSR
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_ACTPJ
Sequence: MSYPQEVNKRRTFAIISHPDAGKTTITEKVLLYGNAIQTAGSVKGKGSSAHAKSDWMEMEKQRGISITTSVMQFPYNNCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDSAKGVEERTIKLMEVTRLRDTPILTFMNKLDRDIRDPMELLDEVESVLKIRCAPITWPIGCGKLFKGVYHIAKDETYLYQSGQGSTIQEVRIVKGLSSPELDAAVGDDLANQLREELELVQGASNEFDHEAFINGELTPVFFGTALGNFGVDHFLDGLTEWAPKPQARQTDVRTVESSEEKFSGFVFKIQANMDPKHRDRVAFMRVVSGKYEKGMKLKHVRIGKDVVISDALTFMAGDRAHAEEAYAGDIIGLHNHGTIQIGDTFTQGEVMKFTGIPNFAPELFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPLMNNDLIVGAVGVLQFDVVVSRLKTEYNVEAIYEAVNVATARWVECGDAKKFEEFKRKNEQNLALDGGDNLTYIAPTMVNLNLAQERYPDINFFKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14Z_CAMC5
Sequence: MAKKSMIAKAARAPKFKVRGYTRCQICGRPHSVYKDFGICRVCLRKMANEGLIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: METJ_ENT38
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPNDEDLRKERSDEIPEAAKVIMRELGIDPDTWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_CHLTB
Sequence: MTHKLTPMMQQWHQCKEQAGDCLLLFRLGEFYEAFFDDALILAQNLDITLTQRQNVPMSGIPATCLDGYVDRLVSRGFKVAIAEQADNTEGSKGLVPRTINRLITPGALLSSSLLPEKANNYVLAINQVGSLYGLSCLDLSIGTFLVAEYDNTKDLIEAICRLAPTELLSHAKFYQKNAAVIKQLQQHLRITLSEYVSWAFEYQSATKKLYTCFQVSSLDGFGLQGLVPAINAAGALLSYIQDKLLLPISHLSIPKIYGQQKHLLIDKASQTNLELLSPIHGEHGKGSLLQVMERTSTPMGGRLLRNTLINPFYDLKEITLRQDSVEFFLQQEDLRKILKRQLSCVRDLERLATKISTSLATPKDIGTLRDSLLSCTHIADNLQNCALPEFLENKFLIAPPLCSLIKTLSTELIQELPLKVSEGNIFANHYHPDLLRLRNIKENSKSWILEYQERIRNETGIKKLKVCYAQALGYYIEVASNLAPQLPKEFIRRQSRLHAERFTTQELQQFQDEVFSVEDKLQTLETKLFKELCFYIVEHRDLILKLSTAVADLDYVVSLAELAAEYDYRRPLVDHSDALSITKGMHPVALTLLDKGTFIPNDTVMHSAQTRMILLTGPNMAGKSTYIRQIALLVIMAQMGSFIPARSAHIGIVDKIFTRIGAGDNLSKGMSTFMVEMAETANILHNATDRSLVILDEIGRGTSTYDGLAIAQAVVEFLLFTDGKKAKTLFATHYKELTELEMHCQHVENFHAMVKENSGQPIFMYEIVKGHSKKSFGIHVAKLAGFPLSVVSRAQQILHQFEGPDLRPEPEKAQQLVMF
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: ZN774_HUMAN
Sequence: MWLGTSGKSGLPGHCLENPLQECHPAQLEEWALKGISRPSVISQPEQKEEPWVLPLQNFEARKIPRESHTDCEHQVAKLNQDNSETAEQCGTSSERTNKDLSHTLSWGGNWEQGLELEGQHGTLPGEGQLESFSQERDLNKLLDGYVGEKPMCAECGKSFNQSSYLIRHLRTHTGERPYTCIECGKGFKQSSDLVTHRRTHTGEKPYQCKGCEKKFSDSSTLIKHQRTHTGERPYECPECGKTFGRKPHLIMHQRTHTGEKPYACLECHKSFSRSSNFITHQRTHTGVKPYRCNDCGESFSQSSDLIKHQRTHTGERPFKCPECGKGFRDSSHFVAHMSTHSGERPFSCPDCHKSFSQSSHLVTHQRTHTGERPFKCENCGKGFADSSALIKHQRIHTGERPYKCGECGKSFNQSSHFITHQRIHLGDRPYRCPECGKTFNQRSHFLTHQRTHTGEKPFHCSKCNKSFRQKAHLLCHQNTHLI
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 774.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ALR_LIGS1
Sequence: MVIGRHRNTRAIISLEAIKHNVATQISKLKDGQSLFAVVKANAYGHGMIPVAKAAKEAGANGFCVAIIDEGIALRESGIKDPILILGVNPASEAVCMAKHDLSVAVGTLEFLTEAQKLLQEEKQRLKIHLALDTGMGRIGFRNTEDLKEAVDFIEKHSDQLKCEGVFTHFSTADSKDPAYFEKQSQKFDELVGVLKKKPKYIHQANSATALWHPNFEGNLVRMGISMYGLNPSGDMIDETWNLEPALSLESELVAVKEVEAGSSIGYGATYTSSQSEWIGTVPIGYADGWLRRMQGFKVLIDGQYCEIVGRVCMDQFMVRLPKKYDLGTKVTLIGENNGKVITAQDVANYADTIHYEIMCNITERVPRIYK
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: MENE_STAA8
Sequence: MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRLTPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTSTGKLQRNKLYRG
What is the function of this protein?
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
What are the official names of this protein?
2-succinylbenzoate--CoA ligase, o-succinylbenzoyl-CoA synthetase, OSB-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
Protein: PDXS_STAES
Sequence: MSKIVGSDRVKRGMAEMQKGGVIMDVVNAEQAKIAEEAGAVAVMALERVPSDIRAAGGVARMANPKIVEEVMNAVSIPVMAKARIGHITEARVLESMGVDYIDESEVLTPADEEYHLRKDQFTVPFVCGCRNLGEAARRIGEGAAMLRTKGEPGTGNIVEAVRHMRRVNSEVSRLTVMNDDEIMTFAKDLGAPYEVLKQIKDNGRLPVVNFAAGGVATPQDAALMMELGADGVFVGSGIFKSEDPEKFAKAIVQATTHYQDYELIGKLASELGTAMKGLDINQISLEERMQERGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: THYX_THEMA
Sequence: MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP or deoxyuridylate) to 2'-deoxythymidine-5'-monophosphate (dTMP or deoxythymidylate) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methylene donor, and NAD(P)H and FADH(2) as the reductant.  This reaction is a critical step in DNA biosynthesis (PubMed:12791256, PubMed:19370033).  Can also use formaldehyde instead of mTHF as a direct methylene donor for dTMP synthesis.  However, the tighter binding of ThyX to mTHF (KD of 4 uM) compared to formaldehyde (KD of 20 mM) confirms that methylene tetrahydrofolate acts as the biological carbon donor for ThyX, serving as a formaldehyde carrier/transporter and thus avoiding genotoxic effects (PubMed:34315871).
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: TRM56_SULAC
Sequence: MEVWGGKSYFKVEFVDNPKKIVKSWREKGGLVVHLTMYGKMIDDMIDEITKASKNFTLPLLVVIGSEKVEGWYYYNSDYNIGIGNQPHSEVSALAIFLDRIYKGEELYIHFSDAKFYIIPQLKGKRVVKTDK
What is the function of this protein?
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
What are the official names of this protein?
tRNA (cytidine(56)-2'-O)-methyltransferase, tRNA ribose 2'-O-methyltransferase aTrm56.
What is the protein family that this protein belongs to?
Belongs to the aTrm56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3A_MONBE
Sequence: MSMNKFFQPKNALKRAEDLEAVGKPNLALETLHDLLNSSKHKKQWTAVHEEIMIKFLDLCMQLKRAPEAKDGLYQFKIVTGTSAVNSLEKVVRYYLKTAEDKVAEAWQQSQLRDATNVNDEIDDLEEAQTPEQVLLAAVSADGETERANRVQLMPWLRYLWEAYRAVLELLRHHSKMEHAYHATARQAMRFCHQYERRNEFRRLCNMLSLHLNQWRTPYQSKSGQAGIDINNPQTIQYSLDTRFELISYAGKLEQWQEAFRAMEEVTGLLDSAPEKPSPPVWGIYYHKLAQIFWRSKDYAFHAAAWHQMFDNAIRNAKSFNRDDIQYAASAVLLASLTVPLANLDTMVKPMEGYLPEVRASRQQRLAGLLGLSRMPSRDELLQYMFDLNVMTYVHPALKDLYNLVEDEFDPLQLSQKAAPVLEFLKSHEQFAQYVTPLKYILLLRLLKQLSQLYSSLKLERCFKLASFMTPEECEEVLVHAVQDKVLQLRIDHARGSLHFNNNIFAFNERQVNDGPKLQNLQAEMMNGQLTTLSRRLYTAINMIKPAVVQESQMGVKAINRIKDEVAREHVSNLSRRDEIEKQKEELEQSRRRRHQEQMQKHHQNQMQVRQKMAEAVKKNQEELERQKLQLQREEIERQKALEALNDVSSSSAGQKVVQALNKSDLGTKITAQDIHKMAYEQQKKDARERQERLRAEEKRLDHMERAKRLREIPRRKEHIAAMSEQNAKWHTELQSARLEKARVDHAKALGLKELLKAFAPDKDAYIEEKTAERRKEYMAKLDDFKQRMQEQKIRLEREERERKREEKRRAEEEEQRRIKQEEEDRKQREREAKREQERQEQLKLEEAERKKMEEATKLQRQREEQVRAREQEKLSNLSAQTSQPTWKRSARSDAPTTAAPSSMRVSSWKGDASDDSGRSQPFRPSRGGERDSGRSFSGLGDRGDRAPRDTGRSFSGLGDRGDRAPRDTGRSFSGLGDRAPRDFSGRSEPSRSGPRDFSGRSEAGRTSGERRALHVPSGGADKPSGDNVWRSSRGAGSERRVNIPSRGDDKN
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit A, eIF3a, Eukaryotic translation initiation factor 3 subunit 10.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_BRASO
Sequence: MAHKKAGGSSRNGRDSKGKRLGIKAFGGERVIPGNIIARQRGTTWHPGLNVGMGTDHTLFAKIEGVVEFHDRANRTFISVRPVAAQAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PPIA_MACMU
Sequence: MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
What is the function of this protein?
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity).  Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity).  Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity).  In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity).  Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity).  Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity).  Plays an important role in platelet activation and aggregation (By similarity).  Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).  Binds heparan sulfate glycosaminoglycans (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Protein: DAPB_SALNS
Sequence: MHEAQIRVAIAGAGGRMGRQLIQAAMAMEGVQLGAALEREGSSLLGSDAGELAGAGKSGVIVQSSLEAVKDDFDVFIDFTRPEGTLTHLAFCRQHGKGMVIGTTGFDDAGKQAIREASQEIAIVFAANFSVGVNVMLKLLEKAAKVMGDYSDIEIIEAHHRHKVDAPSGTALAMGEAIAGALDKNLKDCAVYSREGYTGERVPGTIGFATVRAGDIVGEHTAMFADIGERVEITHKASSRMTFANGALRSALWLKTKKNGLFDMRDVLGLDVL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MET15_MOUSE
Sequence: MLRYPYFYRTYNRLFSHFVDSGASNLDVCPHTIHTAVALHTESKAVEGTALCGPQKVYSSEEKELEAMAKLHIPVMVDQVVHCLAPQKGQVFLDMTFGSGGHTRAILQKEPDVMVYALDRDPVAYAIAEQLSRLYPTQIQALLGQFSQAEALLMKAGVQPGTIDGILMDLGCSSMQLDAPERGFSLRKDGPLDMRMDGDRYPDTPTASDVVNALDQQALASILRAYGEEKHAKKIASAIIQARSTYPISRTQQLASIVAGAFPPSAVYARKDLLQRSTHIATKTFQALRIFVNNELNELYAGLRTAEKFLKTGGRLVALSFHSLEDRIVKRFLLGISMTERFNLSIRQKVKQTSQLDSDQETEERHSVRAPLKWELIHKKVLTPEDQDVQDNPRGRSAKLRAAIKL
What is the function of this protein?
N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA.  Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits.
What are the official names of this protein?
12S rRNA N4-methylcytidine methyltransferase, 12S rRNA m4C methyltransferase, Methyltransferase 5 domain-containing protein 1, Methyltransferase-like protein 15.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ACP_ONYPE
Sequence: MVFEKIKALIATQLSLDASTITLDTRFKEDLGLDSLDALELVMEVEKTFQINISDATLQNFKTVQDIVFYITKNTP
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VES_ECOLU
Sequence: MEYFDMRKMSVNLWRNAAGETREICTFPPAKRDFYWRASIASIAANGEFSLFPGMERIVTLLEGGEMFLESADRFNHTLKPLQPFAFAADQVVKAKLTAGQMSMDFNIMTRLDVCKAKVRIAERTFTTFGSRGGVVFVINGAWQLGDKLLTTDQGACWFDGRHTLRLLQPQGKLLFSEINWLAGHSPDQVQ
What are the official names of this protein?
Protein Ves.
What is the protein family that this protein belongs to?
Belongs to the Ves family.
Protein: RS19_BURCM
Sequence: MARSVKKGPFCDAHLLKKVEAAAASRDKKPIKTWSRRSTILPDFIGLTIAVHNGRQHVPVYISENMVGHKLGEFALTRTFKGHAADKKAKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: NDH1_SCHPO
Sequence: MLFSRSILRGMPKAGIPKSPLALSASRNLRLANSVRFASDAASSPKSTTSKWKILKRTTLGLFATAVVLYGANVYRFRHPDPHQPLPDPSKKTLVVLGAGWGATSILRTIDTSLFNVIVVSPRNYFLFTSLLPSTATGSVHTRSIVQPIRYMLRHKSCYVKFYEAECTDVDADKKVIHIKKTTTDGVDLEQEIKYDYLVCSHGAETQTFNIPGIAEYGCFLKEIWDAQKIRARILHCLEQAQFKDLPAETRRRYVHTVVVGGGPTGMEFAGEMADFIEDDLKSWYPELADDFAVTLVEALPSVLPMFSAKLRDYTQSLFDSSHIKIRTNTALKKVTAENIHVEVKNPDGSKQEEVIPYGLLVWAGGNRARPLTKKLMEGSEEQNNRRGLVVDEYLKLKGYKDIFALGDCTHTAYAPTAQVASQQGAYLGQLFNKLGSLNFEKPSEDRHIALGDEMDSSTLISLANEKHASTKVFLPFKYSHQGSLAYVGHEKAIADIEVPWFGKQLHASGALAFYFWRSVYLSELYSLRNRTNVTLDWIRVKLFGRDISSL
What is the function of this protein?
Catalyzes the oxidation of NADH.
What are the official names of this protein?
Probable NADH-ubiquinone oxidoreductase C3A11.07, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
Protein: LSR2_MYCTO
Sequence: MAKKVTVTLVDDFDGSGAADETVEFGLDGVTYEIDLSTKNATKLRGDLKQWVAAGRRVGGRRRGRSGSGRGRGAIDREQSAAIREWARRNGHNVSTRGRIPADVIDAYHAAT
What is the function of this protein?
DNA-bridging protein that has both architectural and regulatory roles.  Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments.  Represses expression of multiple genes involved in a broad range of cellular processes.  May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels.  Protects against reactive oxygen intermediates (By similarity).
What are the official names of this protein?
Nucleoid-associated protein Lsr2.
What is the protein family that this protein belongs to?
Belongs to the Lsr2 family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DCUP_GEOKA
Sequence: MARQINDTFLRACRGEQTSYVPVWYMRQAGRSQPEYRALKEKYSLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPAIGVNVEIQGGIGPVIANPIRSLQDVERLGEIDPEHDVPYVFETIRLLVNEQLDVPLIGFAGAPFTLASYMIEGGPSKNYHKTKAFMYAEPKAWFALMDKLAEMTIRYVRAQIRAGASAVQIFDSWVGAVSADDYRTFIKPAMARIFAALREEGAPLIMFGVGASHLVHEWNDLPLDVIGLDWRLSIREARRQGIAKAIQGNLDPAVLLAPWDVIEERVKRILDEGMERPGYIFNLGHGIFPDVQPATLKRLTAFIHEYTSTN
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LHA4_RHOPA
Sequence: MNQGRIWTVVKPTVGLPLLLGSVAIMVFLVHFAVLTHTTWVAKFMNGKAAAIESSIKAV
What is the function of this protein?
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
What are the official names of this protein?
Light-harvesting protein B-800-850 alpha chain D, Antenna pigment protein alpha chain D, LH II-D alpha.
What is the protein family that this protein belongs to?
Belongs to the antenna complex alpha subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: RL5_GEOSE
Sequence: MNRLKEKYVKEVVPALMSKFNYKSIMQVPKIEKIVINMGVGDAVQNPKALDSAVEELTLIAGQRPVVTRAKKSIAGFRLRQGMPIGAKVTLRGERMYEFLDKLISVSLPRVRDFRGVSKKAFDGRGNYTLGIKEQLIFPEIDYDKVNKVRGMDIVIVTTANTDEEARELLALLGMPFQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs (By similarity).
What are the official names of this protein?
50S ribosomal protein L5, BL5, BstL5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: Y2317_HALSA
Sequence: MLSVRNLVHRYGDTVAVDGVSLDVADGECVVVTGANGSGKTTLVRHCNGLLEPDDGEVLVNGTPVGEDLVAARASVGMVFQNPRDGFVGATVGADVAFGPENLGRPREEIDARVADALDAVELGGRRDERVADLSGGEQERVAIAAALAMRPDHLVLDEPFTGLDWPARQSVLDRLRALHAAGTSLIVVTHDLRDVWTLADRVVAMRDGEIALRGDPADVRGALPDAGVRPP
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein VNG_2317G.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GREA_HELPJ
Sequence: MNKEPMSMHGYNKICAELKQLKEVERPNIVKEIDIARGHGDLKENAEYHAAKEKQRFIEARIVDLSEIVANAQVIDPSALAHNKVSFGSTIKILNLDNDKEFSYTIVGSVESDPAKGLISFGSPIAKSLIGKSKGDAVSIQLPNGESDFEILDIYYKEICFDEN
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: HAC1_YEAST
Sequence: MEMTDFELTSNSQSNLAIPTNFKSTLPPRKRAKTKEEKEQRRIERILRNRRAAHQSREKKRLHLQYLERKCSLLENLLNSVNLEKLADHEDALTCSHDAFVASLDEYRDFQSTRGASLDTRASSHSSSDTFTPSPLNCTMEPATLSPKSMRDSASDQETSWELQMFKTENVPESTTLPAVDNNNLFDAVASPLADPLCDDIAGNSLPFDNSIDLDNWRNPEAQSGLNSFELNDFFITS
What is the function of this protein?
Transcriptional activator involved in the unfolded protein response (UPR) pathway.  Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes such as KAR2, PDI1, EUG1 and FKB2.  Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway.
What are the official names of this protein?
Transcriptional activator HAC1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.