PharMolix/UniProtQA huggingface dataset:
Protein: QUEA_ECODH
Sequence: MRVTDFSFELPESLIAHYPMPERSSCRLLSLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGAELLLGDDESINATMTARHGALFEVEFNDERSVLDILNSIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQDVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPFFDDTQIFIYPGFQYKVVDALVTNFHLPESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_STAA8
Sequence: MPAVTYEHIKTCKQSGARLGIVHTPHGSFETPMFMPVGTKATVKTMSPEELRQIEAKIILGNTYHLWLQPGNDIIKHAGGLHKFMNWDGPILTDSGGFQVFSLSNLRKITEEGVEFRHHTNGSKLFLSPEKSMQIQNDLGSDIMMAFDECPPMPAEYDYVKKSIERTTRWAKRCLDAHQRPEDQALFGIIQGGEYEDLREQSAKDLVELDFPGYAIGGLSVGEPKPVMYKMVEHTEQFMPKDKPRYLMGVGSPDALIECSIRGMDMFDCVLPTRIARNGTCMTSQGRLVIKNAKFADDLRPLDENCDCYTCQNYSRAYIRHLIKAEETFGIRLTTIHNLHFLLKLMEDIRQAIREDRLLDFKEEFFEQYGLNVENPKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RFCS_HALMA
Sequence: MSEAESESRAGREEVWIEKYRPQTLDDVMGHENIVGRLKSYVSRNDLSHMLFSGPAGTGKTTCATAIARELYGDDWREHFLELNASDERGIDVVRDRIKNFARTSFGGVEYRIIFLDEADALTSDAQSALRRTMEQFSNNVRFILSCNYSSQIIDPIQSRCAVFRFSPLADDAVAEEIRTIAAEEDIELTEDGLDALVYAADGDMRKAINGLQAASVSGDTVDESAVYAITSTARPEEIRTMVQSALDGDFTASRATLDRLLTEEGIAGGDIIDQLHRSIWEFDIDDDAAVRVLERIGETDYRITRGANERVQLEAMLASLAQGE
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C small subunit, RFC small subunit, Clamp loader small subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: RL24_SALNS
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PMIP_PICST
Sequence: MRLSRQLLRSTPFLTRAKPVSGKVSHFRSRTDLKGGSSNSSKSPDSVGDGASAHLRHIFDDQKYFNSFTKSAAETSGKVSSLPAIFSFRRSGLFCNDNLSTPHGLIDFSKNSLREAKSLVESMLHDVKSDPAGRLSYINKLDQLSDILCRVIDVAEFIRVAHPSQKWVNAAQQTHEIMFEYMNQLNTNVELYQNLRDILSDSSVTAQLTEEEIQVGEYLKQDFERSGIHMNPSARNNFVAITQEISLLGSRFNNEIHNLKSYWCEIPRYEFEQLEDSNLKKEILGYQSKAPPSKHSSQTISIPLVGHIPFTILTTCSIESIRREIWISLHNSSDEQIATLNNFLKYRATLAKMLGYKSFSHYQLEHKMAKNPENVVTFLTNLQKSLREKGVTEEIKKLYQYRDDSTISQVQKASTEDIIDGVKPWDRDYLLEKLQKASNKNLEELENINEYLSVGTIVAGLSELFKSIYNVEFVPVATLKGETWDQNQVRKVAVVDDSTKKKLGFLYLDFWSPKVLPSHFTIVCSRKLNLDIKSETKDKMRQLVQLDEDETSQLPVISLICNFQKSNDGHIGRFAGVENEKPTLLSLNQVDTVFHEMGHAMHSMIGRTDLHNLSGTRCATDFVELPSVLMESFSKDPRVLCKIAKHYETGEPLSPKLLAQHQTQKVMLDECETYMQSKMAMLDQVLHSEDVVRTISEDFANFDSTPIYHSLESKLKVFADTWSTWHGKFPHLFSYGAVYYSYLLDRAIAEKIWNGLFAHDPWSREAGEKYKNSILKWGGTRDPWECLADALENDELSKGDSRAMEIIGKDSL
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP, Octapeptidyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CYB_PERAL
Sequence: MTIMRKSHPLMKMVNHAFIDLPAPSNISSWWNFGSLLGVCLMIQIMTGLFLSMHYTSDTLTAFSSVTHICRDVNYGWLIRYMHANGASLFFICLYFHIGRGIYYGSYLYKETWNIGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSDLVEWIWGGFSVDKATLNRFFAFHFILPFIIAAMAMVHLLFLHETGSNNPLGIPSDSDKIPFHPYYSFKDLLGVLILFAFFFTIVLFFPDALGDPDNYSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVIALALSILVLALFPLLHTSNQRSMTFRPISQVMFWILVSDLLILTWIGGQPVEPPFIIIGQAASILYFSIILLLLPIAGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NADD_CHLPB
Sequence: MRLAVFGGSFDPPHNGHLALCLYARELLQVDRLVISASNNPLKDAPQAADRDRVKMAELLAETINRTGAFAEVSSWEANRGHPVYTIDLMEYLEEIYSTSDLTLLIGEDNFLNFRQWKSWEELIRRYSIIVFGRKADDGASDDSAISERLHDQSFRHIDLNLPLSSTEIRKRLASGDDCSAEIPSPIWQYIVENQLYQ
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: ODO2_DELAC
Sequence: AIVEVKVPXLXE
What is the function of this protein?
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: ZIC4_MOUSE
Sequence: MRLGRVCPRGPGKVRSPRHRFSCTLFVSTTGSSCGHHGPQLAASSNPSVLPGLHEQPPQASHSRPLNGLLRLGIPGDMYARSEPFAPGPMARSDTLATATALHGYGGMNLTMNLTAPHGPGAFFRYMRQPIKQELICKWLGDDSPMSPRPCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYMCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSAITSALASPSLESGREPSVACSAAVVVRGTDVSE
What is the function of this protein?
Binds to DNA.
What are the official names of this protein?
Zinc finger protein ZIC 4, Zinc finger protein of the cerebellum 4.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH604_FRACC
Sequence: MPKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGVPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTNDVAGDGTTTATILAQALVREGLRNVAAGANPLGLKKGIEVAVERVSEELSKQAKEVETKEQIASTASISAGDSAIGGLIAEALDKVGKEGVVTVEESNTFGLELELTEGMRFDKGYISPYFVTDADRQEAVLDDPYILIVNSKISAVKDLLPLLEKVMQTGKPLAIIAEDVEGEALATLVVNKIRGTFKSAAVKAPGFGDRRKAILGDIAILTGGQVISEDVGLKLESTSLDLLGRARKIVVTKDETTVVEGAGDPDQIAGRVSQIRNEIEKSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKEKKHRIEDAVSNAKAAVEEGIVAGGGVALLQASITAFEKLDLSGDEATGANIVRLALEAPIKQIAFNSGLEGGVVVEKVRNLPTGHGLNAATGEYVDLIGTGIIDPAKVTRSALQNAASIAGLFLTTEAVIADKPEKNPAPAVPGGGGDMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 4, 60 kDa chaperonin 4, Chaperonin-60 4, Cpn60 4.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP85_HCMVA
Sequence: MSSRRRSSSRRSGEPSTVIYIPSSNEDTPADEEAEDSVFTSTRARSATEDLDRMEAGLSPYSVSSDAPSSFELVRETGGTGAAKKPSEKKRSSSRRQPQIAAGAPRGSPATPKAGKSPKVSRPPSVPSLPENGAGGGGDDNSSSGGSSSRTTSNSSRSTSPVAPGEPSAAEGDEFSFCDSDIEDFERECYRVSVADNLGFEPSVVAPQHVEYLKFVLQDFDVQHLRRLNECIPMPAFALTSLVDPVLNNVAPGERDLTRRIITHAVIINYYYVAQKKARHMVEAIRTTVRGDTVRRVAAQVNNQSRSGRAAALALHFLTSRKGVTDGQYATSLRRLDEELRHRGTPESPRLTEVYQTLRDYNVLFYTAHYTSRGALYLYRQNLQRLNENHRGMLRLLSVEEICEEHTLNDLAFLVGVELMITHFQRTIRVLRCYLQHQLQSISELCYLIYVQLPSLREDYAQLSDVIYWAVSQNYDYALYASTPALFDFLRVVRQQDAFICTDYVYCALRLLACPDRPIIGDTGGSSSSQRLVGEFMVRDPLLRDPRATHLRQKLITRDICVARLQAQPSSRHIPVEHTGVSSVTLLKIFSQVPPDEREEDTLREMALKAFMEANGNHPEQICRSPPPPLPPRDYPQRDERDRHRRDRRDSGEYCC
What are the official names of this protein?
Phosphoprotein 85, pp85, Phosphoprotein UL25.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae pp85 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Note=Expressed exclusively at the cytoplasmic level during the late phase of the virus replication cycle. Also found in dense bodies.
Protein: CD59A_MOUSE
Sequence: MRAQRGLILLLLLLAVFCSTAVSLTCYHCFQPVVSSCNMNSTCSPDQDSCLYAVAGMQVYQRCWKQSDCHGEIIMDQLEETKLKFRCCQFNLCNKSDGSLGKTPLLGTSVLVAILNLCFLSHL
What is the function of this protein?
Potent inhibitor of the complement membrane attack complex (MAC) action.  Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).
What are the official names of this protein?
CD59A glycoprotein, MAC-inhibitory protein, MAC-IP, Membrane attack complex inhibition factor, MACIF, Protectin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: RSE1_MAGO7
Sequence: MATTSNMFLYSLSIQPPSTITRAILGQFSGTKEQQIVAASGSRLTLYRPDPTQGKVVPLMSHDVFGIIRDLASFRLAGSSKDYLIIASDSGRITIVEYLPAQNRFSRIHLETFGKSGVRRVVPGQYLAADPKGRACLIASVERCKLVYVLNRNSQAELTISSPLEAHKNGTLTLSLVALDVGYSNPVFAALEVDYSEVDQDPKGDAAQNVETVLNYYELDLGLNHVVRKWFDVVDSTASMLFQVPGGSDGPSGVLVCGEENITYRHSNQDAFRVPIPRRKGATEDPSRKRNIVSGVMHKLKGSAGAFFFLLQTEDGDLFKVTIDMVEDAEGNPTGEVRRLKIKYFDTIPVSNNLCILKSGFLFVASEFGNHLFYQFEKLGDDDEELEFFSSDFPVDPKEPYEPVYFYPRPTENLALVESIDSMNPLMDLKVANLTEEDAPQIYTVSGKGARSTFRMLKHGLEVNEIVASQLPGTPSAVWTTKLRRDDEYDAYIVLSFTNGTLVLSIGETVEEVSDTGFLSSVPTLAVQQLGDDGLVQVHPKGIRHIRNGVVNEWSSPQHRSIVAAATNERQVAVALSSGEIVYFEMDTDGSLAEYDEKKEMFGTVTSLSLGEVPEGRLRSSYLAVGCDDCTVRILSLDPESTLESKSVQALTAAPSALSIMSMEDSSSGGTTLYLHIGLNSGVYLRTVLDEVTGELTDTRQKFLGPKAVRLFQVSVQKRTCVLALSSRSWLGFSDPVTKGFTMTPLNYEELEWGWNFVSEQCEEGMVGVNGQFLRIFAIEKLGDNVIQKSIPLTYTPRKLAKHPTQRIFYTIEADNNTLAPELREQLMAAPTAVNGDARVLPPDEFGYPRGNGRWASCISVVDPLGDGEELEPGVVQRIDLDNNEAALSMAVVSFASQDGESFLVVGTGKDMVVNPRRFTEGYIHVYRFSEDGRELEFIHKTKVEEPPTALLPFQGRLVAGIGRMLRIYDLGLRQLLRKAQAEVAPQLIVSLNTQGSRIIVGDVQHGLIYVAYKSETNRLIPFADDTIARWTTCTTMVDYDSTAGADKFGNLWILRCPEKASQESDEPGSEVHLVHSRDYLHGTSNRLALMAHVYTQDIPTSICKTNLVVGGQEVLLWGGFQGTIGVLIPFVSREDADFFQSLEQHLRSEDPPLAGRDHLMYRGCYVPVKGVIDGDLCERYTMLPNDKKQMIAGELDRSVREIERKISDIRTRSAF
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle control.
What are the official names of this protein?
Pre-mRNA-splicing factor RSE1.
What is the protein family that this protein belongs to?
Belongs to the RSE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IF1A_ONOVI
Sequence: MPKNKGKGGKNRKRGKNEADDDKRELVFKEDGQEYAQVLRMLGNGRCEAMCIDGTKRLCHIRGKMHKKVWIAAGDIILVGLRDYQDDKADVILKLMPDEARLLKAYGELPDNTRLNEGIGAGGLDEEMDTANDYIEFEDEDIDKI
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 1A, eIF-1A, Eukaryotic translation initiation factor 4C, eIF-4C.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: AMSH_ERWAM
Sequence: MIIIKTKLIPLMVSAALLSGCTIVPGNHLSTMGKDVVEQQDSDFDIDKYVNIFPLTPSLVERMKPKPVVAQANATLQRELQNYEYRIGVGDVLMVTVWDHPELTTPAGQYRSASDTGNWVHSDGTIFYPYIGRVRVAGHTVQETRDEIASRLSKYVESPQVDVNVASFKSQKTYVTGEVTTSGQQAITNVPLTILDAINAAGGLTATADWRNVVLTHDGREQPVSLQALMQNGDLSQNHLLYPGDILYVPRNDDLKVFVMGEVKQQATLKMDRSGMTLSEALGSAQGMDQSVADATGVFVIRPVKGANRSKIANIYQLNTKDAAAMVMGTEFRLEPYDIVYVTSTPLTRWNRVISQLVPTISGVYDATRNVQTIHKW
What is the function of this protein?
Involved in the biosynthesis of amylovoran which functions as a virulence factor.  Might be involved in the translocation of polysaccharides across the outer membrane.
What are the official names of this protein?
Amylovoran export outer membrane protein AmsH.
What is the protein family that this protein belongs to?
Belongs to the BexD/CtrA/VexA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: DBPA_BACCR
Sequence: MSKKSFSDYKLSKEIVRALTGLGYDHPTEVQGEVIPVALQKKDLVVKSQTGSGKTASFGIPLCEMVEWEENKPQALVLTPTRELAVQVKEDITNIGRFKRIKAAAVYGKSPFARQKLELKQKTHIVVGTPGRVLDHIEKGTLSLECLKYLVIDEADEMLNMGFIDQVEAIIDELPTKRMTMLFSATLPEDVEKLSRTYMNSPTHIEIKAAGITTDKIEHTLFEVIEDEKLSLLKDVTTIENPDSCIIFCRTQENVDHVYRQLKRANYPCDKIHGGMVQEDRFEVMDDFRKGKFRYLVATDVAARGIDIDNITHVINYDIPLEKESYVHRTGRTGRAGNSGKAITFITPYENRFLEEIEEYIGFEIPKAIGPSKEEVMKEKAAFEEKLHAKPIIKKDKNADINKGIMKLYFNGGKKKKIRAVDFVGTIAKIKGVTAEDIGIITIQDNVSYVEILNGKGPLVLKVMKTTTIKGKQLKVHEAIK
What is the function of this protein?
DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit.  Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.
What are the official names of this protein?
ATP-dependent RNA helicase DbpA.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DbpA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y541_BACC0
Sequence: MGRKWNNIKDKKASKDANTSRIYAKFGREIYVAAKQGEPDPESNQALRVVLERAKTYNVPRTIIDRAVEKAKGGSEENYDELRYEGFGPNGAMVIVDTLTNNVNRTAADVRAAFSKNSGNMGVNGSVAYMFDATAVIGLEGKTSDEVLEILMEADVDARDILEEEDAVIVYAEPDQFHAVQSALKDAGVEEFTVAELTMLAQNDVTLPEDAQAQFEKMVDALEDLEDVQQVYHNVDLGE
What are the official names of this protein?
Probable transcriptional regulatory protein BCAH820_0541.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_PSEMY
Sequence: MTGKTLYDKLWEMHEVKRRDDGSSLIYIDRHILHEVTSPQAFEGLRLAGRKPWRIDANIATPDHNVPTTKAERQGGLEAIADEVSRIQVQTLDENCDDFGILEFKMNDVRQGIVHVVGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMKNMQVRVEGKLPFGVTAKDIVLAVIGKIGTAGGNGHALEFAGSAIRDLSLEGRMTICNMSIEAGARVGLVAVDEKTIAYVKDRPFAPKGSDWDKAVTQWQNLVSDADAVFDTVVELKAEDIKPQVSWGTSPEMVLAVDQNVPDPAVETDPVKKDSITRALKYMGLSANQPITDIQLDRVFIGSCTNSRIEDLRAAAEVAKGRKVASTVKQALVVPGSGLVKAQAEAEGLDKIFIEAGFEWREPGCSMCLAMNPDKLGSGEHCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAVTGRFIDVRELIQA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: LCD1_YEAST
Sequence: MRRETVGEFSSDDDDDILLELGTRPPRFTQIPPSSAALQTQIPTTLEVTTTTLNNKQSKNDNQLVNQLNKAQGEASMLRDKINFLNIEREKEKNIQAVKVNELQVKHLQELAKLKQELQKLEDEKKFLQMEARGKSKREVITNVKPPSTTLSTNTNTITPDSSSVAIEAKPQSPQSKKRKISDNLLKKNMVPLNPNRIIPDETSLFLESILLHQIIGADLSTIEILNRLKLDYITEFKFKNFVIAKGAPIGKSIVSLLLRCKKTLTLDRFIDTLLEDIAVLIKEISVHPNESKLAVPFLVALMYQIVQFRPSATHNLALKDCFLFICDLIRIYHHVLKVPIHESNMNLHVEPQIFQYELIDYLIISYSFDLLEGILRVLQSHPKQTYMEFFDENILKSFEFVYKLALTISYKPMVNVIFSAVEVVNIITSIILNMDNSSDLKSLISGSWWRDCITRLYALLEKEIKSGDVYNENVDTTTLHMSKYHDFFGLIRNIGDNELGGLISKLIYTDRLQSVPRVISKEDIGMDSDKFTAPIIGYKMEKWLLKLKDEVLNIFENLLMIYGDDATIVNGEMLIHSSKFLSREQALMIERYVGQDSPNLDLRCHLIEHTLTIIYRLWKDHFKQLREEQIKQVESQLIMSLWRFLVCQTETVTANEREMRDHRHLVDSLHDLTIKDQASYYEDAFEDLPEYIEEELKMQLNKRTGRIMQVKYDEKFQEMARTILESKSFDLTTLEEADSLYISMGL
What is the function of this protein?
Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses.  The MEC1-LCD1 complex is recruited by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced.  Required for the recruitment of MEC1 to DNA lesions, the activation of CHK1 and RAD53 kinases and phosphorylation of RAD9 in response to DNA damage.  Required for cell growth and meiotic recombination.
What are the official names of this protein?
DNA damage checkpoint protein LCD1, DNA damage checkpoint protein 2, Lethal, checkpoint-defective, DNA damage-sensitive protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks. The recruitment to DNA lesion sites requires the presence of the RPA complex on DNA.
Protein: HIS7_CALMQ
Sequence: MPRSAVVERRTKETEVKVELSLEPGEVNVDTPVKFLNHMVETLIFYMGASGRVKAIDLRGFDDHHVVEDVAIVLGSTLDKALGDRTGLARFGWAIIPMDDALTLASVDLGGRVYFMFKGSFTRETVGDMATEMVPHFIRSLASSLRATIHVNVMWGENNHHIAESVFKALGLAIGQAIQVKGGGVPSLKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLIA_BOTMO
Sequence: MRLILLSGLLLLGTFLANGDETDPDGQVLNSLIETLMHLQREFANLKYAFLTVHKARSFGSGSERLYVSNKEIKNFEPLGDICSQAGGHIPSPQLENQNKAFANVLERHNKAAYLVVGDSANFTNWAAGQPNEADGTCVKADTHGSWHSASCDDNLLVVCEFYFIL
What is the function of this protein?
This phospholipase A2 inhibitor binds directly phospholipase A2 in the presence or absence of calcium.  Has anti-enzymatic, anti-myotoxic, anti-edema inducing, anti-cytotoxic, anti-bactericidal, and anti-lethal properties against basic and acidic phospholipases A2 from Bothrops venoms.
What are the official names of this protein?
Phospholipase A2 myotoxin inhibitor protein, BmjMIP, alpha-PLI.
What is the protein family that this protein belongs to?
Belongs to the alpha-type phospholipase A2 inhibitor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in plasma.
Protein: XGPT_SALHS
Sequence: MSEKYVVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVIDIPQNTWIEQPWDMGVVFVPPISGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YTFE_SALPB
Sequence: MAYRDQPLGELALSIPRASALFRQYDMDYCCGGKQTLARAAARHDVDIDIIEAQLAQLAEQPIEKDWRAVPLADIIDHIVVRYHDRHREQLPELILQATKVERVHADKPNVPRGLTKYLTALHEELSSHMMKEEQILFPMIKQGMGRQATGPISVMESEHDEAGELVDVIKHVTQNVTPPPEACTTWKAMYNGINEMIDDLMEHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPPH_STRM5
Sequence: MIDPDGYRPNVGIVLMRQDGQVFWARRVRRDGWQFPQGGMNTDETPVEAMYRELQEETGLLPEHVEVLGATPGWLRYKLPARAIRRNERQVCIGQKQVWFLLRLTGDESHVCLDHTDSPEFDHWRWVDFWYPVEHVVMFKRGVYARALRHLAPLAQGVAGQGVTAMPKSAAEAWMPGHTAGHDRPRKRPRSRGYWPKKAQGDVPPT
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: G6PI_YERPG
Sequence: MKNINPSQTAAWKALQQHFEQMKDVTISSLFAKDDQRFNRFSATFDDQMLVDFSKNRITSETLEKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHIALRNRSNTPIVVDGKDVMPEVNAVLAKMKQFCDRVISGDWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEALKPLNPETTLFLVASKTFTTQETMTNAHSARDWFLSAAGDPAHVAKHFAALSTNAKAVGEFGIDTNNMFEFWDWVGGRYSLWSAIGLSIALSVGFEHFEQLLSGAHAMDKHFAETPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFPAYFQQGNMESNGKYVDRNGHPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAISHNPLSDHHAKLLSNFFAQTEALAFGKSLEDVEAEFAAAGKTPEQVAHVAPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIYTFDQWGVELGKQLANRILPELADDQEVTSHDSSTNALINRFKNWR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.