Protein: PGMA_ASPTN
Sequence: MPNTTMELFIFGDQTLDVQPCLRGLAQHRHNPVLEDFFTKTYQVLRTEIDQLPHNVKVGLPRFTCIDDIIFRPPGSKSCIALDMAMTTFYQLGVFIRVTCALGLCTGALAAAAVSCSRNALDLVPMAVDAVRVAFRTGAHVLDIAHRIESPDASDQSWLLYVPAVEAAETALKAFREHTLLPGIRQPYITAYTLNSVMVSGPPSSLEQLKRHAPFRELNPQSVSINGPYHAPHLYSQEDIDDIVGDLACQDVHSCSCRVPVIAGDGNPVPDADFGTILKAAVAQILRQQINWNGILRELLTRHDIAGSLTLTVTTIGTKTDHFIYNVLKQSPLREYLSSKPAQSRQPVSNEGAPEPGNGRQKLAIIGMSGRFPGADDIEEFWTLLEQGLDVHKPVPSLRWDAQTHVDPTRARKNTSSTPFGCWLEHPDLFDARFFNISPREAPQIDPAQRLALMTAYEAIEQAGIVPDATPSTRRDRVGVFYGTTSNDWMETNSAQNIDTYFIPGGNRAFIPGRINYYFKFSGPSYAVDTACSSSLASIHLACNALWRREIDTAIAGGTNVLTNPDFTAGLDRGQFLSRTGNCKTFDDSADGYCRGEGVATVIIKRLEDAVADKDPILGLILSASTNHSAESESITRPHVGAQREILSNILNRGASNPYDVSYVEMHGTGTQVGDASEMSSVLETFAPAPNRVKSARGHDTPLYLGSAKANIGHGEAVSGVSSLIKVLLMMQRNTIVPHCGIKTKINHKFPTDLKDRNAHIALQPVSWERNSASSQTRKVVVNNFSAAGGNSALLVEDAPPKRESPGEAALVDPRQHHVVAVSARNAVSLEGNIRSMLKYLRENPDVQLGKLSYTTTARRLHHQHRVMVTGSKVEDIATQLQAALDEKTGMTRPKAALKVVFAFTGQGAHYPGMGKELFENFSVFRTEVHRLDRLGQTMGFPSVLPVIQSPANDIDIGTFQPSAVQLAGVCTQMALCKLWAAWNITPTAVVGHSLGEYPALNAAGVLSDADTIYLVGKRAQLLEEKCVRGTHSMLAIKASVDQITGALENMKYHVACINSPVETVLAAANEELYALKDVLTAAGFKSTPLKVPYAFHSPQVDPVLADFKELSRGVTFSRPRIPILSALDGNLHVDDHFFDPEYLIRHTREPVNMHRTLLTAAREHVITEMTTVLEIGSHPAVSGMVKGVLGPQVSCLATASRGRPNLQVLAATLKVLYMKGADICWPQYHIDFKASHEVIPLPAYSWDLKSYWIQYVNDWSLRKGDPPQVIQSSPALESTTVHRVVEETHDSTKTRIVIEADIARKDLSPLVQGHEVDGIPLCTPSVYADMALTLGTYLLKRYRPDQNDSLVDVTDMVISKALILRAGASEQLLQAHADADWAANAVTIKFKSFDARQKLQEHSQCVVRFRDRGLLEDLQNSAPSVKAKTQALRDGIVTGETARFNRPMVYRAIRPLAKFHEDYRAIDEIVLNSETLEASSRLSFGDVKRGGTYHTHPAIIDSLTQSCGFTMNCNDRSDLDKEVFMNHGWGSLQIFEPLSFDKVYTTYTRMAEGSDHLWHGDVVIFDGDKVVAYIGQISIQGVPRRVLKTVLSIESGSQKKHQPTQMKQPHTATQANGYPVANGHAQATPTSGPVNGEPRPSRFPRALEIIAEESGLSLADLTDTTVFSDVGIDSLLNLTISSRFKEEFDVDLDFTALSQDYPTVASLRALLSEPERSTNGMPAASAKDTSRFDEIPPMNGHKTNGHVMNGHSNGSSNGLPDTDKVDFQRVLQIISEESGVAMEELSEDTNFADAGIDSLLSLVIVSRFRDELELDIAHESLLMDCQSVADLKRYLFPQDHSTAENGVEPPAKNGLAADAPAVSSMSQDIISNGNGETAQPLGASLLLRQKAVDHYVQKYTAGFNAPIPNGAGNESEKTDNVKVVLVTGASGSLGGHLIDQLAQRADVKTVVCLNREHNLEPYTRQQKAMRDKGIRSFDKIRSKLLVLQTDSSQPMLGLPKSQYEELVDSVTHVIHNAWPMSAKRPLDGFEKQFQILRNLIDFACVVTSRRPKSFKFGFQLVSSIGVVGHHGLSKPHDRKEKTIVPESRVNIDSVLPNGYSEAKWACERMLDETLHKHYADRVRTMVVRLGQIAGSKRCGYWNPTEHFGFLIKSSQTLNALPDVPGMVYWTPVEEVAGSLVDLILADNRPYPVYHVDNPIGQPWSEMNKVLADALNIPNLVPFVEWVERVRSAPHRDNPAAMLSDFFIDNYLRMSCGGLVLDVKNTLEHSRVLSGVGPVTEDVVRKYIHVWKEIGFLK
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of pleosporalin A, ascomycone A, as well as a third cryptic naphthoquinone derived pigment, all responsible for the coloration of conidia (PubMed:28471414, PubMed:35351612).  The non-reducing polyketide synthase pgmA is responsible for the condensation of seven acetyl-CoA units to produce the cyclized heptaketide 3-acetonyl-1,6,8-trihydroxy-2-naphthaldehyde (PubMed:35351612).  The pathway begins with the biosynthesis of the cyclized heptaketide 3-acetonyl-1,6,8-trihydroxy-2-naphthaldehyde by the NR-PKS pgmA.  The C-6 hydroxyl group is further methylated by the O-methyltransferase pgmB to yield fusarubinaldehyde which is in turn oxidized by the cytochrome P450 monooxygenase pgmC at C-9.  The C-1 hydroxyl group is then methylated spontaneously.  Although pgmE, pgmD and pgmH are essential for the production of pleosporalin A, it is not the case for the 2 other final products and it remains difficult to assign a specific function to each enzyme.  PgmF and pgmG seem not to be involved in pigment biosynthesis although they were regulated by the cluster-specific transcription factor pgmR (PubMed:35351612) (Probable).
What are the official names of this protein?
Non-reducing polyketide synthase pgmA, NR-PKS pgmA, Pigmented naphthoquinones biosynthesis cluster protein A.