PharMolix/UniProtQA huggingface dataset:
Protein: SURE_OLEA2
Sequence: MFIALTNDDGIQAPGLRAMYKALKEAGHTVQVVAPVTEQSAVGHAVTIALPLRVKIFAENGFQGMGVYGTPTDCVKLGLNALLDKKPDIVVSGINAGANVGPDILYSGTVSAATEAAHMGYPSLAVSYDNFKPDDIAAHARFAVEIMESMPWQSLPPRCVLNLNLPDVPMQQCKGLTLCPQTRAVWKDWYDHRTDPRGNSYWWLNGIIPPETVAEGTDRDMLTRGYATLTPLRFDFTDRETLARLQQNMDRQRQGSEDL
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_METRJ
Sequence: MATPEFDLNDIKRRMQGAVASLSKDLGSLRTGRATPSLLDPIQVDAYGSMMPMAQVATVSVPEPRLLSISVWDRSMVTAVEKAIRESDLGLNPQTEGQTIRLRIPEMNEQRRKEMVKVAHKYTEEARVAVRHVRRDGLDHLKKLLKDSAISEDDEKRQATDVQKATDQYIAEIDGVLASKEKEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_NITSB
Sequence: MAHKKGQGSTQNNRDSAGRRLGVKKFGGEFVRAGNIIIRQRGTKVHPGNNVGLGKDHTIFALIDGVVKFERYGKDRQKVSVYPVE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: DNAA_XANAC
Sequence: MDAWPRCLERLEAEFPPEDVHTWLKPLQAEDRGDSIVLYAPNAFIVDQVRERYLPRIRELLAYFVGNGDVALAVGSRPRAPEPAPAPVAVPSAPQAAPIVPFAGNLDSHYTFANFVEGRSNQLGLAAAIQAAQKPGDRAHNPLLLYGSTGLGKTHLMFAAGNALRQANPAAKVMYLRSEQFFSAMIRALQDKAMDQFKRQFQQIDALLIDDIQFFAGKDRTQEEFFHTFNALFDGRQQIILTCDRYPREVEGLEPRLKSRLAWGLSVAIDPPDFETRAAIVLAKARERGAEIPDDVAFLIAKKMRSNVRDLEGALNTLVARANFTGRSITVEFAQETLRDLLRAQQQAIGIPNIQKTVADYYGLQMKDLLSKRRTRSLARPRQVAMALAKELTEHSLPEIGDAFAGRDHTTVLHACRQIRTLMEADGKLREDWEKLIRKLSE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_BACC1
Sequence: MKAGIHPDYKKVVFMDTNTGFKFLSGSTRGSNETVEWEDGNTYPLLKVEISSDSHPFYTGRQKFATADGRVDRFNKKYGLK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: NUOK_MYCBO
Sequence: MNPANYLYLSVLLFTIGASGVLLRRNAIVMFMCVELMLNAVNLAFVTFARMHGHLDAQMIAFFTMVVAACEVVVGLAIIMTIFRTRKSASVDDANLLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ENV_EIAV9
Sequence: MVSIAFYGGIPGGISTPITQQSEKSKCEENTMFQPYCYNNDSKNSMAESKEARDQEMNLKEESKEEKRRNDWWKIGMFLLCLAGTTGGILWWYEGLPQQHYIGLVAIGGRLNGSGQSNAIECWGSFPGCRPFQNYFSYETNRSMHMDNNTATLLEAYHREITFIYKSSCTDSDHCQEYQCKKVNLNSSDSSNSVRVEDVTNTAEYWGFKWLECNQTENFKTILVPENEMVNINDTDTWIPKGCNETWARVKRCPIDILYGIHPIRLCVQPPFFLVQEKGIADTSRIGNCGPTIFLGVLEDNKGVVRGDYTACNVRRLNINRKDYTGIYQVPIFYTCTFTNITSCNNEPIISVIMYETNQVQYLLCNNNNSNNYNCVVQSFGVIGQAHLELPRPNKRIRNQSFNQYNCSINNKTELETWKLVKTSGVTPLPISSEANTGLIRHKRDFGISAIVAAIVAATAIAASATMSYVALTEVNKIMEVQNHTFEVENSTLNGMDLIERQIKILYAMILQTHADVQLLKERQQVEETFNLIGCIERTHVFCHTGHPWNMSWGHLNESTQWDDWVSKMEDLNQEILTTLHGARNNLAQSMITFNTPDSIAQFGKDLWSHIGNWIPGLGASIIKYIVMFLLIYLLLTSSPKILRALWKVTSGAGSSGSRYLKKKFHHKHASREDTWDQAQHNIHLAGVTGGSGDKYYKQKYSRNDWNGESEEYNRRPKSWVKSIEAFGESYISEKTKGEISQPGAAINEHKNGSGGNNPHQGSLDLEIRSEGGNIYDCCIKAQEGTLAIPCCGFPLWLFWGLVIIVGRIAGYGLRGLAVIIRICIRGLNLIFEIIRKMLDYIGRALNPGTSHVSMPQYV
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: SEPF_MYCBO
Sequence: MSTLHKVKAYFGMAPMEDYDDEYYDDRAPSRGYARPRFDDDYGRYDGRDYDDARSDSRGDLRGEPADYPPPGYRGGYADEPRFRPREFDRAEMTRPRFGSWLRNSTRGALAMDPRRMAMMFEDGHPLSKITTLRPKDYSEARTIGERFRDGSPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RMT2_ASPOR
Sequence: MTDPTTEIDVDLDVQEILLAASQHDIPKLRQLIRSNQTIANPVNVKDPETGYAPLHAAIAACEPDDEEPNGVQTNGEQGDEQKSVEEKGSATVRFLLQEGAIWNDLDNNNETPGCVARRLGLTELYEQLVDAGVRAELLLNRLDGYEELEDDDEEEEEGQEEQTGTEEVEVEGESAPQLVEATTTTETAMETGPDVTNSRYLDSNLTFQNDRLLDQDQNGVMMAWETDIMAKSAKKLLPTSGLRVLNVGHGMGIVDGFIQEQSPAEHHIIEAHPEVVAEMKRKGWGEKPGVTIHEGRWQDILPDLVGQGVMFDAIYYDTFAESYGDFREFFSEQVIGLLEQEGKWSFFNGMGADRQISYDVYQKVAEMDLMDAGFDVEWEEIALPKLDNEWDGVRRAYWQIESYRLPLCKYMD
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins.  Monomethylates ribosomal protein L12.
What are the official names of this protein?
Protein arginine N-methyltransferase 2, Protein-arginine N5-methyltransferase, Type IV protein arginine N-methyltransferase, Type IV PRMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CCD22_XENLA
Sequence: MEEVDRILIHSLRSCGTEVPEDIQSIRQFNTELIVEAVVRCLRVINPSLGATLSHVLPPGMSAQFRIGTSLAQACQDLGYSSEVGYQTFLYSSEPDIRALLIFLAEKLPRDSSEDAHQPAGKSALLQREIVATIKQQLSLPWLPLSCRIAALRRSQSSCRLHRFHSQPLSLASDPALKSIPNERKEYWQRYLPSVTSQLPHLPSVAASLLERNTSKLSAVQEWEAEWKSQGLASRLSPEDYRSKKQQRLQKRIQEQLRQCAQLLAENHLPSSSSQDLTDMLRAFNLDGGSDQKKGSRFTRTQRFTYQQDPHTLKEQMQRAAEILPKKDAQDADAEQQEISSLQEQIDSIEQEIRGLSESNKLLQLTIGQVEGEVNDMHQSCEEKANVVRVKKRAVELLPDADNNLDKLQTLVDASAQRMANLIGQWESHQARLSDEYMELNRVQQEQEDESSRWMKDAKDLYEKIQGSADEAKRKEELYKQLLSEYESLPKEVSRAAYTQRILEIVSNIKKQKEEITKILSDTKELQKEINNLTGKVDRTFVVTDELVFKDAKKDEPVRKAYKYLAALHENCSQLIQTIEDTGTILREIRDLEEQIETETTKKTLSNLQKILEDYRAIKQENAQLLARTREA
What is the function of this protein?
May be involved in regulation of NF-kappa-B signaling.  May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).
What are the official names of this protein?
Coiled-coil domain-containing protein 22.
What is the protein family that this protein belongs to?
Belongs to the CCDC22 family.
Protein: NUOB1_ANADE
Sequence: MASELDGLPVIATRREEAEGFLQGLVSKSLGWARKYSLFTYPFVTACCGMEYMTMASARYDSDRFGAAMPRFSPRQADLLMVVGTVNCKQAPILQRIYEQMADPKWVMAFGVCASSGGFYDNYATVQGIDRIIPVDVYVPGCPPRPEQVLDGIMLLQKKIQNQSHKLIDRKPLPVIAGGPGR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 1, NADH dehydrogenase I subunit B 1, NDH-1 subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PSA1_RHOER
Sequence: MTMPYYASAEQIMRDRSELARKGIARGRSVVVLTFRDGVLFVAENPSTALHKVSELYDRLGFAAVGKYNEFENLRRAGIVHADMRGYSYDRRDVTGRSLANAYAQTLGTIFTEQPKPYEVEICVAEVGRVGSPKAPQLYRITYDGSIVDEQHFVVMGGTTEPIATAMRESYRADLDLEAAVGIAVNALRQGGAGEGEKRNVDVASLEVAVLDQSRPRRAFRRIAGTALEQLVPAEPAAASESAPEPKPDTETKPADTQD
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.  The R. erythropolis proteasomes are able to cleave oligopeptides after Tyr, Phe and Leu, very poorly after Arg but not after Glu.  Thus, displays chymotrypsin-like activity, low trypsin-like activity but no caspase-like activity.
What are the official names of this protein?
Proteasome subunit alpha 1, 20S proteasome alpha subunit 1, Proteasome core protein PrcA 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_VIBVY
Sequence: MQKTTRTMPAHKHIALVAHDNYKPELLRWVKENKEKLQSHFLYATGTTGHMLSRETGLAIKSMISGPMGGDQQLGALISEGKIDMLIFFWDPLNAVPHDPDVKALLRIASVWNIPVATNRATAKFLFESPLLNEEVDVEIPDYQAYLAGRT
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: EX7L_CLOK5
Sequence: MYIKTLTVSDINRYIKKTLDNDFILGNCSVKGEVSNFKFHSSGHMYFSLKDKFSKINCIMFKSSVEKLNFMPGDGMKVIVKGRISLYEKEGVYQLYCSEMKPDGMGELYLAFEKLKIELEKKGLFDISHKKKIPLYAKKIGVITSPTGAAVKDIINVTRRRNKKIELLIYPSLVQGTGASDNIIKGIETFNSMEDVELIIIARGGGSIEELWCFNDEKLAEAVYSSKKPIITGVGHEIDYTIVDFVSDMRAPTPSAAAEIGVFSLEEYVQKILNYKNKLYNSVKNTVNDKKNRLAFVKKTLEVNNPLTYIANEYENIDKIKESLNFKIKVIINGKKEKLGKINALLSAHNPLNILNKGYCIIEDEQKNVISSIEELNKKYKVDIIMKDGTSKVELIHYKK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_YERPP
Sequence: MTAIAPVITVDGPSGAGKGTLCKALAESLNWRLLDSGAIYRVLALAALHHQVDISTEEALVPLAAHLDVRFVSQNGQLQVILEGEDVSNEIRTETVGNTASQAAAFPRVREALLRRQRAFREAPGLIADGRDMGTIVFPDAPVKIFLDASSQERAHRRMLQLQERGFNVNFERLLAEIQERDNRDRNRSVAPLVPAADALVLDSTSMSIEQVIEQALAYAQRILALPLKK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTMB_PENSI
Sequence: MDGFDVSQAPPEYRSVEPIANLFVLGMGLGWLINYVGMIYQSFKDETYGMAIMPLCCNIAWEIVYSLIYPSKSLTEQGVFIAGLTINIGVMYAAIKFAPKEWSHAPLVMRNLSLIFFLATLGFLTGHLALAAEIGHSLAYSWGAVVCQLLLSVGGLCQLLCRGCTRGASYTLWLSRFLGSSCTVGFASLRWMYWPESFSWLNSPLVLWSLALFLTVDGSYGICYWYVRQYELSLKEAEGRKSK
What is the function of this protein?
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
Terpene cyclase ptmB, Penitrem biosynthesis cluster 1 protein B.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RNAS1_PYGNE
Sequence: MALDKSVILLPLLVVVLLVLGWAQPSLGRESRAKKFQRQHMDSGSSPSSSSTYCNQMMKRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQTNCFKSNSKMHITDCRLTNGSKYPNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: PQQC_XANC8
Sequence: MTALLSPDQLEADLRAIGARLYHDQHPFHALLHHGKLNRGQVQAWALNRFEYQRCIPLKDAAILARMEDPALRRIWRQRILDHDGNSPSDGGIARWLHLTDALGLPRELVESGRALLPGTRFAVQAYLHFVREKSLLEAIASSLTELFAPNIIGQRVAGMLQHYDFVSPEALAYFEHRLTEAPRDSDFALDYVKQHADTIEKQQLVKAALHFKCSVLWAQLDALHVAYVSPGVVWPDAFVPERDSKRAAA
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: RS14_LEVBA
Sequence: MAKKSKIAKAKRIEATVEKFANRRAELKAAGDYAALALLPRDASPTRIHRRDHLDGRPHAYMRKFGLSRLNFRQLAHEGKIPGVQKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: Y3472_BACVZ
Sequence: MANEFRVCDDCQATNIKTLLPRLKEADPDAKVEVGCQSYCGPGRKKSFAFVNNRPLSAPTEDELIEKVKKKIKK
What are the official names of this protein?
UPF0741 protein RBAM_034720.
What is the protein family that this protein belongs to?
Belongs to the UPF0741 family.
Protein: CRCB2_PARMW
Sequence: MAEQFSMLRSELTELLLVAVGAVPGALLRWQLAHHLGDQNLLVNVLGAALLGLLAGRPVAPRRQLLVGIGFCGSLTTFSSWMLAAMKHVSAGDWPAALGLIGLTLGLGLGAAALGFSLGRRLRPPEQPRSEP
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KRA21_HUMAN
Sequence: MTGSCCGSTFSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPVTCVPRCTRPICEPCRRPVCCDPCSLQEGCCRPITCCPSSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQPTPCSTTCRTSSC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
What are the official names of this protein?
Keratin-associated protein 2-1, High sulfur keratin-associated protein 2.1, Keratin-associated protein 2.1.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 2 family.
Protein: TSAD_HELPY
Sequence: MILSIESSCDDSSLALTRIEDAQLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNKDFSKIKAIAITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKQTCMPLSVLLVSGGHSLILEARDYENIKIVATSLDDSFGESFDKVSKMLDLGYPGGPIVEKLALDYRHPNEPLMFPIPLKNSPNLAFSFSGLKNAVRLEVEKNAPNLNEAIKQKIGYHFQSAAIEHLIQQTKRYFKIKRPKIFGIVGGASQNLALRKAFENLCDAFDCKLVLAPLEFCSDNAAMIGRSSLEAYQKKRFVPLEKANISPRTLLKSFE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M1_I51A0
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: EMC6_HUMAN
Sequence: MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656).  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231).  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151).  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231).  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835).  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
What are the official names of this protein?
ER membrane protein complex subunit 6, Transmembrane protein 93.
What is the protein family that this protein belongs to?
Belongs to the EMC6 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DUT_HHV2H
Sequence: MSQWGPRAILVQTDSTNRNADGDWQAAVAIRGGGVVQLNMVNKRAVDFTPAECGDSEWAVGRVSLGLRMAMPRDFCAIIHAPAVSGPGPHVMLGLVDSGYRGTVLAVVVAPNGTRGFAPGALRVDVTFLDIRATPPTLTEPSSLHRFPQLAPSPLAGLREDPWLDGALATAGGAVALPARRRGGSLVYAGELTQVTTEHGDCVHEAPAFLPKREEDAGFDILIHRAVTVPANGATVIQPSLRVLRAADGPEACYVLGRSSLNARGLLVMPTRWPSGHACAFVVCNLTGVPVTLQAGSKVAQLLVAGTHALPWIPPDNIHEDGAFRAYPRGVPDATATPRDPPILVFTNEFDADAPPSKRGAGGFGSTGI
What is the function of this protein?
Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.