PharMolix/UniProtQA huggingface dataset:
Protein: GLYA_LEPBP
Sequence: MSYLEKQDPEVYAALKKEDERQEHSLEMIASENFVSRPVLEAYHSTLTNKYAEGYPGKRYYNGCENADRVEELAIERAKKMFGAEYANVQPHSGAQANMAVFLATLEPGDSFLGMNLAHGGHLTHGSAVNISGKYFKPIPYGVDEKTETINYDEVAKLAKEHKPKLIVVGASAYPRVIDFNKFREIADGIGAKIMADIAHISGLVVAGEHPSPIGVCDFVTTTTHKTLRGPRGGLILSSSEHEKILNSRVFPGIQGGPLMHVIAAKAVAFGEALQPDFKTYIKQVVKNAKTLAEVFQKRGFRVVSGGTDNHIVLLDVSVKGLTGKDAADGLDHIGVTVNKNAIPFDKNPPAVASGIRLGTPALTTRGLKEKEIEAVGNLICDYLEHFGDTSFESKVKAAVKEITGAFPMNHFRLED
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAP12_CAPGB
Sequence: MRGKRIFIGSSSEELRLAEQAKKILEKNTNYQVTIWNENMWDKAVFRLNNSYLNDLIRATLHFDFGILIGTKDDKVIFRGSEEIQPRDNVLFELGLFIGRLGLNNCAFLVDEEIKILSDVKGISLARFKEKDSDSFNNAVLSIRESFDRQNDSDINFFPSSTLAAVYYENFIKPTCSHIINNGGLLDKNGYIYKKCTIKIIIPKKLTSDVNSQFQRIKAKIETKELSFEYLGRPRNINVEIIAEDGEVMIIDFPTILSGINYAISNLLPQDFNSMSVDYEAILSRELERFVYTLKKIALRDGFDDLIKIVDEDN
What is the function of this protein?
The effector protein for this CBASS system.  Binds c-di-GMP(synthesized by the cognate CdnE encoded upstream in the same operon), and about 10-fold less well 3'3'-cGAMP, but not c-di-AMP, 2'-3'-cGAMP or cUMP-AMP (tested without the N-terminal TIR domain) (PubMed:32877915).  Upon activation by c-di-GMP forms filaments which hydrolyze NAD(+); filament formation is required for enzyme activation (By similarity).
What are the official names of this protein?
CD-NTase-associated protein 12, Cap12, NAD(+) hydrolase, TIR-STING, CgSTING.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the bacterial STING family.
Protein: PXDNL_HUMAN
Sequence: MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPELVKGTCCPVCRDRGMPSDSPEKR
What is the function of this protein?
Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.
What are the official names of this protein?
Probable oxidoreductase PXDNL, Cardiac peroxidase, Inactive peroxidasin-like protein, Polysomal ribonuclease 1, PRM1, Vascular peroxidase 2.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. XPO subfamily.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Cell membrane. SUBCELLULAR LOCATION: [Isoform PMR1]: Cytoplasm. Note=Associates with polysomes.
Protein: RS5_FRATF
Sequence: MSNEVKKNEELIEKLVSVKRHSKTVKGGRIMSFAALTVVGDGKGRIGVGRGKSREVPAAIQKAMENAKKNMVSVNLNNDTLWYPVMSNHGASKVFMQPASAGTGIIAGGAMRSVFEAVGVHNVLAKTYGSTNPANVVRATIAGLAKIKSPDEIAEKRGLSVEEIQG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: FLZ8_ARATH
Sequence: MLKKRSRSKQALMAETNQSQNQKQSKTTPFPRLFTAFSSFKSFTENDAVASPTSILDTKPFSVLKNPFGSDNPKTQEPETRLKLEPKRIGLAIVDSLIQDETPEPGPRSGTILFGSQLRIRVPDSPISSSDFGIKTRNSQPETKKPGSESGLGSPRIISGYFPASDMELSEDYTCVTCHGPNPRTIHIFDNCIVESQPGVVFFRSSDPVNESDSDYSPPDSFLSCCCNCKKSLGPRDDIFMYRGDRAFCSSECRSIEMMMSEENDTK
What is the function of this protein?
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
What are the official names of this protein?
FCS-Like Zinc finger 8.
What is the protein family that this protein belongs to?
Belongs to the FLZ family.
Protein: LRC55_MOUSE
Sequence: MGDTWAQLPWPGPPHSALLLVFFLLAAGVMHSDAGTSCPVLCTCRNQVVDCSNQRLFSVPPDLPMDTRNLSLAHNRIAAVPPGYLTCYMELRVLDLRNNSLMELPPGLFLHAKRLAHLDLSYNNLSHVPADMFREAHGLVHIDLSHNPWLRRVHPQAFQGLVHLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRWSKANEEEEI
What is the function of this protein?
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha).  Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity).
What are the official names of this protein?
Leucine-rich repeat-containing protein 55, BK channel auxiliary gamma subunit LRRC55.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: YX09_CAEEL
Sequence: MKEVEENFKLHSIPSCAAKEKMGATFSNESALHGTVLGHLLNLPNVNTEVLKAIYKMITVNGNQDKLSDIGISKFLTKWRTVYFSNKKPLIDALNNRFYDDVVNEEFEHFINKQNDNYMEARAEIGLLIELYHKDYLKSNFLNNDALEKLIILIIATDYMPMNFFPIFNYSCSTTDPSFKSHLLNSIQNLFLVGYEPILDKLLFI
What are the official names of this protein?
Uncharacterized protein C03B1.9.
Protein: ABCF1_PANTR
Sequence: MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQVQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPASDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVASRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYEGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPRE
What is the function of this protein?
Required for efficient Cap- and IRES-mediated mRNA translation initiation.  Not involved in the ribosome biogenesis (By similarity).
What are the official names of this protein?
ATP-binding cassette sub-family F member 1, ATP-binding cassette 50.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope.
Protein: LPXA_PSESM
Sequence: MSLIDPRAIIDPTAILADSVEVGPWSIIGPGVEIGEGTVVGPHVVLRGPTKIGKHNRIYQFSSVGEDTPDLKYKGEETRLVIGDHNVIREGVTIHRGTVQDRAETTLGDHNLIMAYAHIGHDSVIGNHVILVNNTALAGHVHVDDWAILSGFTLVHQFCHIGAHSFSGMGTAIGKDVPAFVTVFGNPAEARSMNFEGMRRRGFSEEAIHALRRAYKTVYRQGLTIAQALSDLAEPAAQFPEVAVFLQSIQTSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLAT_RAT
Sequence: MPILEKAPQKMPVKASSWEELDLPKLPVPPLQQTLATYLQCMQHLVPEEQFRKSQAIVKRFGAPGGLGETLQEKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFQDTNDQLRFAACLISGVLSYKTLLDSHSLPTDWAKGQLSGQPLCMKQYYRLFSSYRLPGHTQDTLVAQKSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAKARTVLLKDSTNRDSLDMIERCICLVCLDGPGTGELSDTHRALQLLHGGGCSLNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMMTSNKKLVRADSVSELPAPRRLRLKCSPETQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKYSPDGFIQVALQLAYYRLYQRLVPTYESASIRRFQEGRVDNIRSATPEALAFVQAMTDHKAAMPASEKLQLLQTAMQAHKQYTVMAITGMAIDNHLLALRELARDLCKEPPEMFMDETYLMSNRFVLSTSQVPTTMEMFCCYGPVVPNGNGACYNPQPEAITFCISSFHSCKETSSVEFAEAVGASLVDMRDLCSSRQPADSKPPAPKEKARGPSQAKQS
What is the function of this protein?
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
What are the official names of this protein?
Choline O-acetyltransferase, CHOACTase, ChAT, Choline acetylase.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
Protein: MSRB_BURL3
Sequence: MSHDSDDKTFPYEKDDAELRRRLTPMQYEVTQHAATERAFTGEYTDTEDDGIYKCVVCSTPLFESGSKFHSGCGWPSYFKPLNGEVIDEKVDYSHGMVRVEVRCNHCGAHLGHVFEDGPRDQTGLRYCINSAALNFESRPENE
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: SYL_MARMS
Sequence: MQEQYNPQQIEQAAQSFWDENKVFKAIADSSKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVISRYQRMQGKNVLQPMGWDAFGLPAENAAIKHKTAPAKWTTENIAYMKGQLKELGFGYDWDREIATCTPEYYKWEQWFFTQLVEKGLAYKKTAAVNWCPEDQTVLANEQVEDGCCWRCGTNVEKKEISQWFIRITDYAEELLNDLDQLDGWPEKVKAMQRNWIGRSEGLEFSFAVEGKDERLSVYTTRPDTIMGVTYVAVATQHPLSLEASANNADLAAFIEESKKMSTTEADMATVEKKGMDTGFKAIHPITGEAVPVYAANFVLMDYGSGAVMSVPAHDQRDFEFAKKYNLAIKQVVQPAGDEVIDLEKAAFTEKGVLCNSGEFDGLAFKEAFDAIAAWMVERNLGEVKVNYRLRDWGVSRQRYWGTPIPTINLKDGSVVPVPQDQLPVELPTDVIMDGVNSPIKNNPDFSSIMFNGEEAERETDTFDTFMESSWYFARYCCPDSTDAMLTEEANYWLPVDQYVGGVEHAILHLLYSRFFHKLLRDAGLVNSDEPFKRLLTQGMVNKDGTKMSKSKGNTVDPQEMIEKYGADTVRLFMMFSAPPEQSLEWNDAGVDGASRFLRRLWALSYRHTNAGKVGELNIAELNGAQKALRRKTHETIQKVSDDIERRQTFNTAIAAVMELCNEISKFEDSSELGLAVEQEALEAATLLLSPIVPHIAHQLWSELGHSDNIVNTPWPTLDEEALIKDELTIVVQVLGKKRAELTVSANADNKTIEAEALAHPSVAKLLEGKTVRKVIVVPGRLVNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERC_STRS2
Sequence: MTIYNFSAGPAVLPKPVLERAQAEFLDYNGSGMSVLEMSHRSKDFDDIIKGAEATLRELMAIPDNYKVIFLQGGASLEFTMIPLNFAQGKKAYYLVGGSWGKKAYTEAVKLSKTIAFEPILLGSTEDITYAELPTFDKNDIDPTAAYVHLTTNNTIEGTAVYDIPDTNGVPVIADMSSNILAARYNVEDFAMIYAGAQKNIGPAGVTVVIVREDFLNDQPMLSSMLDYRIQAENDSLYNTPPAYSIYISKLVFEWVKEIGGVDEMEKINREKSGLLYDYIDQSNFYTNPVRKKEERSVANIPFVSPSEELDAKFVKEATAAGFKNIKGHRSVGGMRASLYNAFPRQGVVELIEFMKKFAVENA
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1368_STAAS
Sequence: MTKQIIVTDSTSDLSKEYLEANNIHVIPLSLTIEGASYVDQVDITSEEFINHIENDEDVKTSQPAIGEFISAYEELGKDGSEIISIHLSSGLSGTYNTAYQASQMVDANVTVIDSKSISFGLGYQIQHLVELVKEGVSTSEIVKKLNHLRENIKLFVVIGQLNQLIKGGRISKTKGLIGNLMKIKPIGTLDDGRLELVHNARTQNSSIQYLKKEIAEFIGDHEIKSIGVAHANVIEYVDKLKKVFNEAFHVNNYDINVTTPVISAHTGQGAIGLVVLKK
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein SAS1368.
Protein: GUCD1_MOUSE
Sequence: MRTEAEAAGQPLEPGDFVQLPVPIIQQLYHWDCGLACSRMVLRYLGQLDDGEFENALQELQLTRSIWTIDLAYLMRHFGVRHRFCTQTLGVDKGYKNQSFYRKHFDTEETRVNQLFAQAKACKVQVEKCTVSVQDIQVHLAQGHVAIVLVNSGVLHCDLCSSPVKYCCFTPSGHRCFCRTPDYQGHFIVLRGYNRATGCIFYNNPAYADRMCSTSISNFEEARTSYGTDEDILFVYLDS
What are the official names of this protein?
Protein GUCD1, Guanylyl cyclase domain-containing protein 1, Protein LLN4.
Protein: TRI16_HUMAN
Sequence: MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGIDRKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVYIDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP
What is the function of this protein?
E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages.  Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2.  Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B.  In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
What are the official names of this protein?
Tripartite motif-containing protein 16, E3 ubiquitin-protein ligase TRIM16, Estrogen-responsive B box protein.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEA_AERS4
Sequence: MTNWSSKDSLKVYNVPYWGAGFFNINDAGHVTVAPDKSRPDAHIVISDAIEQLRQSGLTTPVLLRFPDILKSRVDALFNAFGQAIEKSGYEGDYLCVYPIKVNQQSRVIETISQSYSDKPRLGLEAGSKPELLAVLSHHHEQGSVIVCNGYKDREYIRHALLGNLMGHKVYIVVEKPSELEMVLDESARLNIKPNIGVRAKLASTGSGMWESSGGSMSKFGLSASQILALVERLRSLDKLDCLQLLHFHLGSQIANIRDIQGGIRECGRFYSELRRLGVPIDVVDVGGGLGVDYEGTRSQSHCSANYSLSEYANNVVWGIGDVCREFDLPYPTIISESGRALTAHHAVLVTNLIGAEGVEMSDISAPDEDAPTLLQNMWQGWLDLRGEDPSLLEIFHDSVADLGDVNTQYTMGLLNLEQRAWAEMLHQNTCLALKEMLNPVNRNHRALADELSEKLADKCFANFSLFQSLPDAWGIGQVFPVMPLTGLDRPLSRRGILMDITCDSDGQVEHYVDGLGVESTLPMPQYEENEVCYVGFFLVGAYQEILGDLHNLFGDTHCAEVCLDEEGKMDIRNVVRGDTVDQLLRYVNIDPSVIRENYQRIVSHPALDDATRKALLDELELGLQGYAYLEDE
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: CHRY5_GIBZE
Sequence: MHLQALTGLATLAVTAASQTLWSRDVDYKALSKELSASAKVYFPGTEDFDAASKRWSNLDKPTVNIVAVPATENDVVEITLDLTQANTLRQVKFANKKNLPFLAQNSAHGAITTLGQMKQGIEIYLNQLSGVKIAKDGKSVTILGGTASKKVTMGLWEAGKQTVTGCCECVGYVGPALGGGHGWLQGRHGLIADQFESMNIVLANGTLATVDENSELWWALKGAGHNFGIVTSVTSKTYDAKIKNWAFASLTFKGEKVEELYETINKYILKNGTQPTDLINWSYWFNIPDLDPTGPIVQILLMQEGVDVVDKAYTGPFQELKPLAVDAKKGVYTDLAKWVGVTTEDGPCQKNGAMNPRFPIYLQDYNPAAQKKAFNYFADNIRGDSIFNGSLVTFDGYSTEGVKAIDSKSTAFAYRNQNILVGPLLSYQSNGTATDEKASEIGHKVRDILHEGTGRDTVPVYVNYAFGDEGPKEWYGSEAWRQSRLQELKEAYDPKGMFSFYAPIA
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398).  Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable).  If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable).  This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable).  The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable).  A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable).
What are the official names of this protein?
FAD-linked oxidoreductase chry5, Chrysogine biosynthesis cluster protein 5.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: YQF7_SCHPO
Sequence: MNAEEDPKPADSDSSEECIICLSNLPNCPLDQWDSSSVPASISSTLDGLRIAKIPCGHYFHNHCLESWCRVANTCPLCRTEFLKVDVLEFVKGPWYRAYPVEEKTQSVANAGEPFEDEGSETCRCVICGRSDHAEVLLLCDGCDDAYHTYCLNMDAVPIEEFYCPNCVLLNYQENETLSSRISLSRRGQTRRRRVGAAARASRVSQQQQRAWTRAWNAIRNRAWDALNSDLSYYGMQQERLPARDVSSELLRRRIESARLRSNQLNEPVEQPRVVQTPVTNASEQQAWNDFDEILHANSSVHSVATEATISNPRPSSGRFQQTPIEEHHQQDTRFVNDPNSTSHDRRQKRPTRRHIPCSNKSSGSSTVLGNNSSSKSENSFLASLISNINQPSTSRIDTSFMLSLQHEIKNSHSEASDGTSDVHLTPLFSNLSPRPSHVPLSPREISNDNLDDHLIELSEPGEIVDNHLVNDTSMHQRRTSGRHDLVHSSKKVSYETKYRIERLVNAALKPYYREAKISKDQFALFNKNICRSVYTALSDGTLSLEGPQQHKISKTIREKVVNCIQSLSND
What are the official names of this protein?
PHD and RING finger domain-containing protein C126.07c.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: IMPA1_HUMAN
Sequence: MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED
What is the function of this protein?
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.  Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
What are the official names of this protein?
Inositol monophosphatase 1, IMP 1, IMPase 1, D-galactose 1-phosphate phosphatase, Inositol-1(or 4)-monophosphatase 1, Lithium-sensitive myo-inositol monophosphatase A1.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCC3_HUMAN
Sequence: MPGSDTALTVDRTYSYPGRHHRCKSRVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPHCMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVLLGRCINVILAFMTVILVCVSTIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIERMIIPR
What are the official names of this protein?
Transmembrane and coiled-coil domain protein 3.
What is the protein family that this protein belongs to?
Belongs to the TEX28 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Concentrates in discrete patches along peripheral endoplasmic reticulum tubules.
Protein: PP256_ARATH
Sequence: MAVTGVSSAFGRLFKQDKTHKRVIGTGTKLTVTRQILEHLEGGNVSKAVSVLFASPEPVSYWLYERLFRSCSSKALVVQARKVQSHLVTFSPLPPIFLLNRAIEAYGKCGCVDDARELFEEMPERDGGSWNAVITACAQNGVSDEVFRMFRRMNRDGVRATETSFAGVLKSCGLILDLRLLRQLHCAVVKYGYSGNVDLETSIVDVYGKCRVMSDARRVFDEIVNPSDVSWNVIVRRYLEMGFNDEAVVMFFKMLELNVRPLNHTVSSVMLACSRSLALEVGKVIHAIAVKLSVVADTVVSTSVFDMYVKCDRLESARRVFDQTRSKDLKSWTSAMSGYAMSGLTREARELFDLMPERNIVSWNAMLGGYVHAHEWDEALDFLTLMRQEIENIDNVTLVWILNVCSGISDVQMGKQAHGFIYRHGYDTNVIVANALLDMYGKCGTLQSANIWFRQMSELRDEVSWNALLTGVARVGRSEQALSFFEGMQVEAKPSKYTLATLLAGCANIPALNLGKAIHGFLIRDGYKIDVVIRGAMVDMYSKCRCFDYAIEVFKEAATRDLILWNSIIRGCCRNGRSKEVFELFMLLENEGVKPDHVTFLGILQACIREGHVELGFQYFSSMSTKYHISPQVEHYDCMIELYCKYGCLHQLEEFLLLMPFDPPMQMLTRINDACQRYRWSKLGAWAAKRLMNDHYLQPP
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At3g26540.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-A subfamily.
Protein: UPPP_META3
Sequence: MDIIQVIVLSIIEGITEFLPISSTGHLIIVSNLMNLAQNAVQTNFEITIQLASIFAVCYEYREKFYNNLELWKKIIISFIPVGIMGLLFHKIVYQLFTVQIVATAFIVGGIIFLIVEKYYKEKEHNIKDLKDISYKQSLLIGIAQAFSLIPGTSRSGATIVGGMLCNLNRKTATEFSFLGALPVMLAASLFDIVKHHSELGSGDISNLVVGFIVSFFMALITIRLFLKYIEKYNFVPFGIYRILFGVILLMFFVR
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: WDR44_HUMAN
Sequence: MASESDTEEFYDAPEDVHLGGGYPVGSPGKVGLSTFKETENTAYKVGNESPVQELKQDVSKKIIESIIEESQKVLQLEDDSLDSKGKELSDQATASPIVARTDLSNIPGLLAIDQVLPEESQKAESQNTFEETELELKKCFPSDETCEKPVDETTKLTQTSSTEQLNVLETETEVLNKEAVEVKGGGDVLEPVSSDSLSTKDFAAVEEVAPAKPPRHLTPEPDIVASTKKPVPARPPPPTNFPPPRPPPPSRPAPPPRKRKSELEFETLKTPDIDVPKENITSDSLLTASMASESTVKDSQPSLDLASATSGDKIVTAQENGKAPDGQTVAGEVMGPQRPRSNSGRELTDEEILASVMIKNLDTGEEIPLSLAEEKLPTGINPLTLHIMRRTKEYVSNDAAQSDDEEKLQSQPTDTDGGRLKQKTTQLKKFLGKSVKRAKHLAEEYGERAINKVKSVRDEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFDQIKVVQDLSGEHMGAVWTMKFSHCGRLLASAGQDNVVRIWALKNAFDYFNNMRMKYNTEGRVSPSPSQESLSSSKSDTDTGVCSGTDEDPDDKNAPFRQRPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIKASFSHDFTYLVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNAVVTSAIFAPNPSLMLSLDVQSEKSEGNEKSEDAEVLDATPSGIMKTDNTEVLLSADFTGAIKVFVNKRKNVS
What is the function of this protein?
Downstream effector for RAB11.  May be involved in vesicle recycling (By similarity).
What are the official names of this protein?
WD repeat-containing protein 44, Rabphilin-11.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia.
Protein: MT_NEUCR
Sequence: MGDCGCSGASSCNCGSGCSCSNCGSK
What are the official names of this protein?
Metallothionein, MT.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 8 family.
Protein: RPOZ_CAMJE
Sequence: MDKRIEEVAAKALEKMGNDRYRLSLVVAKRAEQLANGATPLVDFDKNKNKLADIALYEIAENKITLEGLVETNR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.