PharMolix/UniProtQA huggingface dataset:
Protein: KEFB_PECAS
Sequence: MESSALLTAGVLFLFVAVVAVPIAARLGIGAVLGYLIAGIAIGPWGLGFIRDVEAILHFSELGVVFLMFIIGLELNPGKLWTLRRSIFGVGAAQVGLSALILGGALYLTDFSWQSALIGGVGLAMSSTAMALQLMREKGMNRNESGQLGFSVLLFQDLAVIPALALIPILAGVQGDFGDWERIGLKVAAFLGMLIGGRYLVRPLFRFIAASGVREVFTAAALLLVLGSALFMEALGLSMALGTFIAGILLAESEYRHELEIAIEPFKGLLLGLFFISVGMALNLGILYTHIVKIMIAVLVLVAVKGAVLYFLARINRMRRSERLQFAGVLSQGGEFAFVLFSAAASFNVLKGEQLPLLLVTVTLSMMTTPLLMQVIDRVLARRYNVQDVPDEKPYVEDDEPQVIVVGFGRFGQVISRLLMANKMRITVLERDISAVSLMRSYGYKVYYGDATELELLRSAGADKARSIVITCNAPEDTMEIVHLCQQHFPNLEILARARGRVEAHELLQTGVRHFSRETFSSALELGRKTLVTLGMHPHQAMRAQQHFRRLDMRMLRELMPQLTGDVAQISRVKEARRELEDIFQREMLRERRRPSVWDEDDE
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefB, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ECOT2_LEIIN
Sequence: MPAGMSGAAGKTLANFKAPYPEPTSQQRRYVIFLDPKGYRKELNDYKVELIPGRVEKVDGANVYRMGGSIEERTIDGWGYTYYVVTLTTMSGTLMMPLGDAALKRPRFVAMSTNNLYRYNSQLPIVVYTPKDGELRYRIWTVKSTGSGTAKSINAREM
What are the official names of this protein?
Ecotin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
Protein: RL15_BACFN
Sequence: MNLSNLKPAEGSTKTRKRIGRGPGSGLGGTSTRGHKGAKSRSGYSKKIGFEGGQMPLQRRVPKFGFKNINRIEYKAINLETIQKLAEAKKLEKVGVNDFIEAGFISSSQLVKVLGNGTLTAKLSVEAHAFSKSAVAAIEAAGGNVVKL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL10_KLEP7
Sequence: MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRVVEGTQFECLKDTFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPASQIDRLATLPTYEEAIARLMATMKEASAGKLVRTLAAVRDAKEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RS10_DEIRA
Sequence: MVAPKIRIKLRGFDHKALDQSASKIVDTVRRTGADVSGPVPLPTRIRRFTVLRSPFKYKDSREHFEIRTHNRLVDIMNPTKKTIDSLMTLDLPTGVDIEIKTVGGRA
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: PIL1_YEAST
Sequence: MHRTYSLRNSRAPTASQLQNPPPPPSTTKGRFFGKGGLAYSFRRSAAGAFGPELSRKLSQLVKIEKNVLRSMELTANERRDAAKQLSIWGLENDDDVSDITDKLGVLIYEVSELDDQFIDRYDQYRLTLKSIRDIEGSVQPSRDRKDKITDKIAYLKYKDPQSPKIEVLEQELVRAEAESLVAEAQLSNITRSKLRAAFNYQFDSIIEHSEKIALIAGYGKALLELLDDSPVTPGETRPAYDGYEASKQIIIDAESALNEWTLDSAQVKPTLSFKQDYEDFEPEEGEEEEEEDGQGRWSEDEQEDGQIEEPEQEEEGAVEEHEQVGHQQSESLPQQTTA
What is the function of this protein?
Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway.  Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.
What are the official names of this protein?
Sphingolipid long chain base-responsive protein PIL1.
What are the subcellular locations of this protein?
Lipid droplet.
Protein: TRIA_DICDI
Sequence: MEIEPVVRISFNGNNNQNNNNNNNNNTNNNSNNNNNNNNSSNINSTNKPSVKKPINQKMISNINNQKSPNPLNSSVDDNNNTNNNNNSNSNGTDEDIIKLARDLTNTFGILLGDSDQPSQFSDVIFKVGDRKFFASKIMLVARSEYFKAMFTGSMKESSIKEITLEGVDPDVFFTVLKYICIGILDLDYDHRMVSSIYQYCDLLGLQRGKELSLATMGKIAQMYLEKPDVESALFLWDSLNQSAIPVESVHPHLRAFVLQYASISLHCDAFYSISLTTLVQMLRNDGLRMEELDILDCVIDWCRENSQASIQQQQQQQQQQLQSANGASGKSHGKRSSSSHLKKHDGDGGSDGSCSSRCSSRRNSLSLKDHHRQHIGNGGGGGGHYNNNDCHSDTEETYSDIDDEEHRNGGGGVGDDFENDSEDGDDDDEDDDEDDDFTDDDDKDDSANDDYEYSTNKDDLDIIEDWDTTIDKNLLDEVLPLIRWENMNIGEAFERLDNLKIIPDKEISNLLRHILKSNRGESFSFLGYHYRRPRNNRKRPYPIEFLLGITQPFDSNVTNEIIPLNSFSSEFGQSTNQFLYRIKKDIKLPANLERFSFKDREFFVQLKEREKGQLAVYLAFGSKLTKPLAISVLASVIGFRFQDSIEFSFKKMFDEGFDSAWGWPKFISLDTLYKQDKYSHYSDSFCLLIELTSQWG
What is the function of this protein?
Required for normal morphogenesis and cell-type stability.
What are the official names of this protein?
Trishanku.
Protein: PB2_I73A4
Sequence: MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIMEMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSTIHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKIAPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGTRMVDILKQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKGAEVLFQNWGIEPIDNVMGMIGILPDMTPSTEMSLRGVRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTIIYSSSMMWEINGPESVLVNTYQWIIRNWEIVKIQWSQDPTMLYNKMEFEPFQSLVPRATRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTAGVESAVLRGFLILGKENKRYGPALSINELSNLTKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: HOS2_YEAST
Sequence: MSGTFSYDVKTKENEPLFEFNSAYSPRVSYHFNSKVSHYHYGVKHPMKPFRLMLTDHLVSSYGLHKIMDLYETRSATRDELLQFHSEDYVNFLSKVSPENANKLPRGTLENFNIGDDCPIFQNLYDYTTLYTGASLDATRKLINNQSDIAINWSGGLHHAKKNSPSGFCYVNDIVLSILNLLRYHPRILYIDIDLHHGDGVQEAFYTTDRVFTLSFHKYNGEFFPGTGDLTEIGCDKGKHFALNVPLEDGIDDDSYINLFKSIVDPLIMTFKPTLIVQQCGADSLGHDRLGCFNLNIKAHGECVKFVKSFGLPMLVVGGGGYTPRNVSRLWTYETGILNDVLLPEDIPEDIPFRDSFGPDYSLYPMLDDLYENKNSKKLLEDIRIRCLENIRYLQGAPSVRMDAECIPTQDISALTEEEDKIIQEMNEETEADSSNRLEEMEKENSGLIAFS
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  It is apparently involved in transcriptional activation.
What are the official names of this protein?
Probable histone deacetylase HOS2.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOA_SHEB8
Sequence: MQGSVTEFLKPRLVDIEQVNSTRAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSSKEGVQEDILEILLNLKGLAVTIEGKDEAMLTLSKSGAGPVIAADITHDGDVTIVNPDHIICHLTGNNDISMRIRVERGRGYVPASARAQTEDDDRPIGRLLVDASFSPVARIAYNVEAARVEQRTDLDKLVIDMTTNGTIDPEEAIRRSATILAEQLDAFVELRDVTEPELKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASLADDL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: TRMFO_RUBXD
Sequence: MPDVTVVGGGLAGSEAAWQAARAGCRVELWEMRPVKETPAHHTDLFAELVCSNSLGNRSPETASGLLKEELRRLGSVILRCADANAVPAGGALGVAREDFARAVTETVGSHPNIEVVRREARDIPEGPAVIATGPLTSDALHRKIEELSGETLYFFDAASPILHRDSIDDSVVYRASRYGRGEADYLNCPMDEETYYAFVEELASAELSPIKKFEEDMYFEGCLPVETIARRGPDTLRFGPMKPVGLPDPRTGREPFAVVQLRQDDAEGRLYNIVGFQTRLRWGEQKRVFRMIPGLQRAEFARFGVMHRNTYLPSNRMLEATMKIRNALSERPLFFAGQLTGVEGYVESTAMGYIAGTNAARVARGLEPIRWPEGTMMGALARYITTKEGTLQPINSNWGLVPAPPKRENGRRLGRQERRRRQAEMALGVLERFAGEVLRPPVAAGR
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARHG1_RAT
Sequence: MGEVAGGAAPGPPRSGLVSIIIGAEDEDFENELEANPEDQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLSSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPSVAFELDRTRPDLISEDVQRRFIQEVVQSQQAAVTRQLEDFRSKRLMGMTPWEQELSLLEPWIGKDRGNYEARERHVAERLLSHLEEMQHTISTDEEKSAAVVTAISLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPPKTKKGLSSILDPARWNRGEPSAPDCRHLKVEVDEKPGPADRKGSLGISSRDRTVGTPGQDNPGVSLHPLSVDSLDSREPGVDTPQEPGDTPPQGPTSLEPLAPPESTEDNGETESPEPGDDGEPGRSGLEQEPEEPPGWRELVPSDTLLGLPKNQVKRQEVISELLVTEAAHVRMLRVLHDLFYQPMAEGGFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPAERAKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKKLVHEGPLTWRLTKDKAVEVHVLLLDDLLLLLQRQDEGCCSSHTSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTSSERKSWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGTGGTEAAPADARTERILNDLLPFCRPGPEGQLAATALQKVLSLKQILLSTEEDSGAGPPRDGDGVPGGGAPGPTHTQEVEENLLSLEVVIKQLEELEEEFCRLRPFLSQLGEILSPNLAAPERSAQTGLS
What is the function of this protein?
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits.  Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase.  Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain.  This GEF activity is inhibited by binding to activated GNA12 (By similarity).  Mediates angiotensin-2-induced RhoA activation.
What are the official names of this protein?
Rho guanine nucleotide exchange factor 1, Lbc's second cousin.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
Protein: COX2_ARATH
Sequence: MIVLKWLFFTISPCDAAEPWQLGFQDAATPIMQGIIDLHHDIFFFLILILVFVLWILVRALWHFHYKKNAIPQRIVHGTTIEILWTIFPSIILMFIAIPSFALLYSMDEVVVDPAITIKAIGHQWYWTYEYSDYNSSDEQSLTFDSYMIPEEDLELGQLRLLEVDNRVVVPAKTHLRIIVTSADVLHSWAVPSLGVKCDAVPGRLNQISILVQREGVYYGQCSEICGTNHAFMSIVVEAVSRKDYGSWVSNQLIPQTGEA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COAX_CLOB1
Sequence: MILVLDVGNTNIVLGIYKNKELIANWRLATDNKRTADEYGIQVIELFSHNNLSFSDIEGVIISSVVPNIMYSLEHMISKYFNIKPIIVGPGVKTGINIKYDNPKEVGADRIVNAVAAHEIYKKPLIIIDFGTATTFCAVTKEANYLGGTICPGIKISSDALFDKAAKLPRVELVKTPGVICKNTVASIQSGIIYGYAGQVDYIVSKMKKEMMDLGEEEPFVVATGGFAKLISEESKSIDEINAILTLEGLRVIYEKNK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_BACCN
Sequence: MRKPTALIILDGFGLREETYGNAVAQAKKPNFDRYWNKFPHTTLTACGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFDKNETFQNAIKHVKEKGTALHLFGLLSDGGVHSHIDHMFALLRLAAKEGVEKVYIHAFLDGRDVGPQTAKGYIDATNAVIKETGVGQFATIAGRYYSMDRDKRWDRVEKCYRAMVYGEGPTYKNAYECVEDSYANGIYDEFVLPSVIVNEDETPVATINDDDAVIFYNFRPDRAIQIARVFTNEDFREFDRGEKVPHIPEFVCMTHFSETVNGYVAFKPVNLDNTLGEVVSQAGLKQLRIAETEKYPHVTFFFSGGREAEFPGEERILINSPKVATYDLKPEMSIYEVTDALVNEIENDKHDVIILNFANCDMVGHSGMMEPTIKAVEATDECLGKVVEAILAKDGVAIITADHGNADEELTPDGAPMTAHTTNPVPFIVTKKDVELREGGILGDIAPTMLTLLGVEQPKEMTGKTIIK
What is the function of this protein?
Essential for rapid growth and for sporulation.  Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RIPA_MYCTU
Sequence: MRRNRRGSPARPAARFVRPAIPSALSVALLVCTPGLATADPQTDTIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSEGGQGAPPFRMWDPGSGPAGGRAWDGLWDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGILQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRTAGMTPYVVRYIEY
What is the function of this protein?
Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate.  Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1).  Required for normal separation of daughter cells after cell division and for cell wall integrity.  Required for host cell invasion and intracellular survival in host macrophages.
What are the official names of this protein?
Peptidoglycan endopeptidase RipA, Macrophage invasion and intracellular persistence protein A, Resuscitation-promoting factor interaction partner A, Rpf-interacting protein A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C40 family.
What are the subcellular locations of this protein?
Secreted. Note=Localizes to the septa upon expression in M.bovis or M.smegmatis. Remains associated with the cell.
Protein: HTPG_MYCVP
Sequence: MAAHVEQLEFQAEARQLLDLMIHSVYSNKDSFLRELVSNASDALDKLRLESFRNKDLDVDTSDLHIEIDVDKEARTLTVRDNGIGMTRDEVVSLIGTLAKSGTGELRQQLREAKDKDTSEELIGQFGIGFYASFMVADRVELLTRKAGESEATRWESSGEGTYTIETVDQAGGEVPQGTSVTLHLKPEDREDELHDYTSEWKIRELVKQYSDFIAWPIRMEVERRTPAPEDGGEESVTVETETLNSMKALWARPRDEVSDEEYTEFYKHVAHAWDEPLEVIAMKAEGTFEYQALLFIPSHAPFDLFNQNAAVGVQLYVKRVFIMGDCDQLMPPYLRFVKGVVDAQDMSLNVSREILQQDRQIRAIRRRLTKKVLSTITEMQTERPEKYRTFWTQFGRVLKEGLLTDIENQETLLRVCSFASTHSEDEPTTLAEYVERMPDGQSQIFYAAGESRQQLLHSPHLEAFKAKGYEVLLLTDPVDEVWVESVHEFDGKPLQSVAKGEVDLDSDADNDGQDAERQEREQGFADLIAWLKEALSDHVKEVRLSTRLTDSPACLITDTFGITPALARMYRASGQPVPVEKRILELNPNHPLITGLREAHKSRGADAELVGTAELLYGTALLAEGGVLEDPARFAGLLADRLTRTVGDQT
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRGV8_HUMAN
Sequence: MLLALALLLAFLPPASQKSSNLEGRTKSVTRPTGSSAVITCDLPVENAVYTHWYLHQEGKAPQRLLYYDSYNSRVVLESGISREKYHTYASTGKSLKFILENLIERDSGVYYCATWDR
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447).  Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1.  Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588).  Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT.  This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089).  Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes.  The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames.  The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).
What are the official names of this protein?
T cell receptor gamma variable 8.
What are the subcellular locations of this protein?
Cell membrane.
Protein: SCAF_GAHVM
Sequence: MNPADHPSVYVAGYLALYGADESDELNIDRKDIRAAIPTPAPLPINIDHRRDCTVGAVLALIDDEHGLFFLGKINCPVMVRTLETAASQEIFSELDNLKPDDKLLYIITNYLPSVSLSSRRLAPGETADETFLAHVALCLLGKRIGTIVTYDLTPEEAIEPFRKLSPNSKATLLSQGKETERLLGEMVWYPSKNAITKALLGTAVNNMLLRDRWQIISERRRMAGITGQKYLQASSFTALTDSMTSNNVSVTHPICENANPGNIQKDEEMQVCISPAQTSETLNAGVLSGCNDFHRLPHSDPASTSDQTNLQSLIEPSMNTQSSRPPGDDFIWVPIKSYNQLVSRNASQPTNIPDIAITSNQPPFIPPALMNTSISGQHSIPSGYAQYGYPTPVGTHNSLLPLGPVNQMGGFQYGPQVYPLSYGQSPLEAKLTALLECMTKEKRPVDEEHRGDDMHTTREERGRRGRKRPYEFDRSIESDLYYPGEFRRSNFSPPQASSMKYEETTGGRHDLSQTGPVLNSLMGAVTSLQKEVERLNGGNLPISNAQSSYGVPNGMHAPVYYSYPPPGTHPTVSWPMGVERPMPSTEGKTSTNSTVIPVPVSDPEAGRNVPITATISQERSDGIQKESIEQSRDTMNASAVAGIHRTSDAGVDVFINQMMAHQ
What is the function of this protein?
Plays a major role in capsid assembly.  Acts as a scaffold protein by binding major capsid protein.  Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid.  Cleaved by assemblin after capsid completion.  The cleavages products are evicted from the capsid before or during DNA packaging.
What are the official names of this protein?
Capsid scaffolding protein, Capsid protein P40, Protease precursor, pPR, Virion structural protein UL26.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae capsid scaffolding protein family.
What are the subcellular locations of this protein?
[Capsid scaffolding protein]: Host cytoplasm. SUBCELLULAR LOCATION: [Assemblin]: Host nucleus. SUBCELLULAR LOCATION: [Assembly protein]: Host nucleus.
Protein: RS13_AMOA5
Sequence: MARILGVDIPDNKRGEIALTYIFGIGRSSANQILAAAGVNKDKRVSSWTDEESQTIRTVINENYKVEGELKSEIRLNIKRLVDIGCYRGRRHVLGLPVRGQSTKNNARTRKGKRKTVANKKKAAKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: TKT_MYCTO
Sequence: MTTLEEISALTRPRHPDDWTEIDSAAVDTIRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSKTPGHPEFRHTPGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDRNQISIEDDTNIALCEDTAARYRAYGWHVQEVEGGENVVGIEEAIANAQAVTDRPSFIALRTVIGYPAPNLMDTGKAHGAALGDDEVAAVKKIVGFDPDKTFQVREDVLTHTRGLVARGKQAHERWQLEFDAWARREPERKALLDRLLAQKLPDGWDADLPHWEPGSKALATRAASGAVLSALGPKLPELWGGSADLAGSNNTTIKGADSFGPPSISTKEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPAVRLAALMDIDTIYVWTHDSIGLGEDGPTHQPIEHLSALRAIPRLSVVRPADANETAYAWRTILARRNGSGPVGLILTRQGVPVLDGTDAEGVARGGYVLSDAGGLQPGEEPDVILIATGSEVQLAVAAQTLLADNDILARVVSMPCLEWFEAQPYEYRDAVLPPTVSARVAVEAGVAQCWHQLVGDTGEIVSIEHYGESADHKTLFREYGFTAEAVAAAAERALDN
What is the function of this protein?
Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate.  Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity).
What are the official names of this protein?
Transketolase, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: CAS1_THEPD
Sequence: MRLLVLRGVDEVTVSSRSTVVIKSGNRVFERALRDVDAVLVVGSGIKISSSLPPVLALHGIPLSILAKGHVAVLLNPVGTKYNNYRALQYTLPKNKALAIALEYLKSRVRGMASIIRNRGGRLPALPEPPDPALYEDPARLESDIRSWEAAASNTLWDEVFKLLDPSAARELRERYGFAGRKPGHPDPLNKAISAMYAVLYTLSTKALVAAGLDPTYGFLHRTQYSVPLAFDYAEAFKPLAVEAALDLVNEEGLPTLSEDGDLDKDSLNKAMKRLYRYLSAKHRETGKTPYQQIHLKAFCLAKHLEGKCSREKLAFTWDKKRYIIHE
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endonuclease Cas1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endonuclease Cas1 family.