Protein: CLAI_PENCR
Sequence: MGDAPIQPQTPAIAVVGMACRLPGSNNSIHAFWNFLKQARQASNTVPESRFNVGAHADGSGKPKTMTSVPGMFLEDIDIGAFDAGFFNISPAEAMAMDPQQRQLLEVAYECLENSGISVDAIFGREMGCFVGSFVGDYADMMARDPEERPTTAATGIGRAILSNRISHFFNLKGPSMTIDTGCSGSLVAVDLACRYLEAGDIESAFVAGSGILHGWADGYAKSEGVNCVMLKNLDSAIRDGDPIRAVIRGWATNSDGYTPGITHPSVDAQVACIKRAYAKAGIEDYSQTGYLECHGTGTPIGDAVETTAIANVFAQSRDDSRPLIIGSVKSNIGHSEAASGLSGLIKSVMAIENGVIPGTPSFITPNPNINFQALRLHVSQTSIPWPLNTIRRASINSFGYGGTNCHLIVEDARLHLGVEQNETYNSSLCSSTSLSLDEDDPRDVVYPRPYIIVLSAVDDDSLTINCKKLLRHLADLHVHLKLPDLSYTLATRRSHHSKRAFAVSNSLNLHARDFMRGQKQFENPRIGFIFTGQGSQWPQMGKDLVRTFPRALEIISEMDAVLQGLPDAPTWSLLDMLVEPHDASRIRQPEISQPLVTAIQLTLVALLEDWNIFPDNVIGHSSGEIAAAYAAGYISKEDAIINAFYRGHAAKVASDSNLSVGMMAVGLGKDEIRPHLEDLADSVYVACVNSPRSITLSGVKTSLEMLRDRLSSVGIFVRILQVDLAYHSPFMKTIGDRYEHSLGQNLPVVGEQPSNTRHTSMFSTVTGEVIKNNPDSQYWRKNMCSPVQFWQGLAAMLSDSEPDLLVEIGPSNTLAGPVRQTNDNLANSSKVEYFSALKRGEDPIGALFDLCGQLYLRGCPIKLERVNRGYEQTNTPPAIVDLPNYGWNHSFSYWNENESSKDWRFRRYLPHDLLGSKILGTTWHTPSWKNTLRLRSLPWLEDHKIGSDVIFPAAGYISMAIEALYQATCAVNEQHAGFSISQLHFSLRNVEFKRAMILDHTSDTRLVLTLESQKGINSWRLFRISSFDGKQWTEHCTGLIRTSEEDSLVQKDLVMPKMIHATPAQVWYRKFADIGYGYGPSFEKMLLVEARVGAAQNRCVISMQAPAAAQSPSFYPIHPTCLDACLQSVFPSLWQGDHTAISTLLLPARIDSLVIHPQPNSINSNVASAKSTYSGRGRLQDRTSWSSDCSLNREEDGKCVLRINGLRFSSVDLGSVQPAAQFWYRSVWCPDITKWSFMPQKHWIPRPNTVNELINWVVHKHGEVSIIELNWDSDDASSLWLDRADHPMRDLTKKYRLLLSDHESLVKSQNLFPNHASSMQMILDRDDPLSGPEWPKMQLVILKSSDCSVHDSSMGRLLGQISEIMSTDGMLVIVAQSLGSDSHSNDARSDSSVFMEHEDRSKSYVPFSHLLSLDLPSSAKHVQLYSRASPAPSCPPQPVALYSFQKTSPISKGLRESLTQNNISLSEVSIHGPETVEIGIGLVVDEIYAPLLCNISSQQWESLKTLFERETPVLWVTQGAQHQVTNPDSSLIYGYLRSLRAEGNASSRFVILDVENGDSPGSRTAITTLLSEMSSSPDRFDHEWEFCERSGIIHVNRIYQDRKLNNLDDIEPAQTSIASCDEKVALHATHLGSLEALQWTQEDTEDSILAPGDVEVKIDVAGLNFKDVALAMGIVHGDEYRLGHEGSGRIQRVGSQTAGYQVGDRVAVFSIGSFANRIQVSTELIHHIPDNMSFEDAATLPLVYSTALYSLLDVANLQANQSVLIHSATGGLGIACIQIAQYIGAKVYATAGTQEKRELLCKEYSIPESQVFSSRDTRFVAGIRGATQGGGVDVIVNTLTGDLLHESWMLCADGGIFVELGKKDIIERNSLSMEPFDRNCSFRAVDLSHKQITDTMKKGLLTRIFDMIKCGNIGPIRPQTTFALNDIQSAFAHMRSARHIGKILILAKDDADTSVPVHSSRRPISIPGDRTYLIVGGLRGLCGSLAICLAQRGAKHITIISRSGCNDERSKAIIADCENLGCRIVDAVGDVTSLQHVKNVFQKADPPIRGVIHGAMVLRDKPIETMSAVDFHQTISSKVKGAWNIHHAAAEQDKSQSLEFFTMLSSISGVVGQKGQANYAAANVFLDSFAAYRCSLGLPAHSLDLGVVDAIGVAAEKGGMERYFNLEHWPRIKESKLHEILCISIDEQKKARYSQLITGLPSGISQLPILSQDARFSILCAEDSQTEGHQPVSPSKDTSSKELYEFRLLVKAMKAKSQLVEKAVTLCGLQLSRLLYLKNQVIDANKSLAAYGLDSLIAIEFRNWLKKELAVEMSTFEVIGASCLHALAEKMVSKVEAGVPVVEVV
What is the function of this protein?
Highly reducing polyketide synthase; part of the cla gene cluster that produces clavatol and ortho-quinone methide (PubMed:30811183).  The clavatol biosynthesis cluster cla and the terrestric acid cluster tra are both involved in the production of peniphenones and penilactones (PubMed:30811183).  The non-reducing PKS claF is responsible for the formation of clavatol from successive condensations of 3 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit, and 2 methylation steps (PubMed:30811183).  The esterase claE probably collaborates with claF by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (By similarity).  The clavatol oxidase claD then converts clavatol to hydroxyclavatol (PubMed:30811183).  Spontaneous dehydration of hydroxyclavatol leads to the accumulation of the highly active ortho-quinone methide (PubMed:30811183, PubMed:31860310).  On the other hand, the PKS-NRPS hybrid traA is involved in the formation of crustosic acid, with the help of traB and traD (PubMed:30811183).  The polyketide synthase module (PKS) of traA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 3 malonyl-CoA units (PubMed:30811183).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with L-malic acid (PubMed:30811183).  Because traA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase traG (By similarity).  Crustosic acid undergoes decarboxylation and isomerization to the terrestric acid, catalyzed by the 2-oxoglutarate-dependent dioxygenase traH (PubMed:30811183).  Both acids are further converted to the 2 gamma-butyrolactones (R)-5-methyltetronic acid and (S)-5-carboxylmethyltetronic acid, with involvement of the cytochrome P450 monooxygenase claJ (PubMed:30811183).  Spontaneous addition of the methide to these gamma-butyrolactones leads to peniphenone D and penilactone D, which undergo again stereospecific attacking by methide to give penilactones A and B (PubMed:30811183, PubMed:31860310).  The function of the highly reducing polyketide synthase claI has not been investigated yet (Probable).
What are the official names of this protein?
Highly reducing polyketide synthase claI, Clavatol biosynthesis cluster protein I.