PharMolix/UniProtQA huggingface dataset:
Protein: Y248_SYNFM
Sequence: MIAWALIFLAVAIAAGVLGFGGIIGAQAWIAQVLFILFLVFFLVSLLSGRKPPVT
What are the official names of this protein?
UPF0391 membrane protein Sfum_0248.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL10_MYCBT
Sequence: MARADKATAVADIAAQFKESTATLITEYRGLTVANLAELRRSLTGSATYAVAKNTLIKRAASEAGIEGLDELFVGPTAIAFVTGEPVDAAKAIKTFAKEHKALVIKGGYMDGHPLTVAEVERIADLESREVLLAKLAGAMKGNLAKAAGLFNAPASQLARLAAALQEKKACPGPDSAE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ENO_HISS2
Sequence: MAKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGLAAAPSGASTGSREALELRDGDKARFLGKGVLKAVSAVNNEIATALVGKEASNQAEIDQIMIELDGTENKSKFGANAILAVSLANAKAAAASKGMPLYAWIAELNGTPGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEALRIGAEVFHNLAKVLKGKGLSTAVGDEGGFAPNLESNAAALACIKEAVEKAGYVLGKDVTLAMDCASSEFYNKENGMYEMKGEGKSFTSQEFTHYLEGLCKEYPIVSIEDGQDESDWDGFAYQTKVLGDKVQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRIAKYNQLIRIEEALGEKAPFLGLKAVKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: NOP58_YEAS7
Sequence: MAYVLTETSAGYALLKASDKKIYKSSSLIQDLDSSDKVLKEFKIAAFSKFNSAANALEEANSIIEGKVSSQLEKLLEEIKKDKKSTLIVSETKLANAINKLGLNFNVVSDAVTLDIYRAIKEYLPELLPGMSDNDLSKMSLGLAHSIGRHKLKFSADKVDVMIIQAIALLDDLDKELNTYAMRCKEWYGWHFPELAKIVTDSVAYARIILTMGIRSKASETDLSEILPEEIEERVKTAAEVSMGTEITQTDLDNINALAEQIVEFAAYREQLSNYLSARMKAIAPNLTQLVGELVGARLIAHSGSLISLAKSPASTIQILGAEKALFRALKTKHDTPKYGLLYHASLVGQATGKNKGKIARVLAAKAAVSLRYDALAEDRDDSGDIGLESRAKVENRLSQLEGRDLRTTPKVVREAKKVEMTEARAYNADADTAKAASDSESDSDDEEEEKKEKKEKKEKKRKRDDDEDSKDSKKAKKEKKDKKEKKEKKEKKEKKEKKEKKSKKEKKEKK
What is the function of this protein?
Required for pre-18S rRNA processing.  May bind microtubules (By similarity).
What are the official names of this protein?
Nucleolar protein 58, Nucleolar protein 5.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NAHF_PSEU8
Sequence: MKTKLFINNAWIDSSDQQTFERIHPVSSDVVTESANATVTDAIKAAQAAEEAFKTWKAVGPSERRRLLLKVADVMESKTPKFIEVMAMEVGASALWAGFNVHASANVFREAASLATQIQGETIPTDKAETLSMTLRQPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSPATHALITQCVQEAGLPAGVLNYLNSSPDRSPEIADALISAKEIRRINFTGSTRVGSIIAQKAAQHLKRCLLELGGKSPLIVLDDADIDAAVKAAVFGSFLFQGQICMSTERLIVDEKIADEFVAKFVEKTKRLSAGDPCVTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGGLAQGALMPATILDHVKSDMRIYDEETFGPITVVIRCKGEAEAVRIANDSVYGLSSGVFGRDINRALRVGMSIEYGSVHINGSTVQNEAQAPYGGTKNTGYGRFDGRAVIDEFTEIKWLTIEPFEQQYPF
What are the official names of this protein?
Salicylaldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: ATPE_ACIBS
Sequence: MATMQCDVVSVKESLYSGAVTMLIAKGAGGELGILPGHAPLVTLLQLGPIRVLLENGTEEIVYVSGGVLEVQPHVVTVLADTAIRADNLDEAAILEARKNAEQLLANQKSDLDSAAALAALAETAAQLETIRKIKNRAQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MIC60_CANAW
Sequence: MIRITSRSVKEAAGIRSVSSSTVRLNIAPKVVSPPVPPPVKPQGSEIPPPPPPPPLKAKRFSLFGFLFKTTLLATVVYGGTLYAATKNDKVMDFVIDKQLPFHEELIDLIENGSTEDLQEAWEQLKNKFTDVKLPTKDDIDELTQKLEHRGEDIIKETKKKIASTHIGHKSGTDLTPTEQLQRGVEIESVKKDVAHLPLIELNSDLGKSVDETVKQTITSFNNFIQSIDASSLATKDDKLITSINTSVNQLASRLNSLTKDFDNELQNKLKVSQTELFSSFTKKELELTENLLHQFSTEKQQLEAKLNQKLSQEIQAARAAISQAASNAVAMVRIEQTKNFEKLVSEKLNEERNGRLANLEKLNDRIVELEKFAEGFETQIVSNHKKAIIHQAVSKLKSLLLAPAAGDKPQPIKPYIDELTKIATDDEVLALAIKDLSPLITNESTHSILTNAQLLSRWEQLAPELRSASLLPPNAGLLGHLASIVFSKLLLPVKGVKEDGKDIESVIGRVESSLARGELDIAVEEAANLKGWSRKLANDWVVEGRKRLEIEFLLGLIESESKII
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Plays a role in keeping cristae membranes connected to the inner boundary membrane.  Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
What are the official names of this protein?
MICOS complex subunit MIC60, Mitofilin.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic60 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: MFI_HUMAN
Sequence: MPWKEESEFTKQDKAARVIQQAWKSFLNVAIFQHFKSLIDLRRQGEPRQIVKYINPKEAELLDAAAGIHVRFRLGGVKFPPDIYYKIFTHRPIEDLCANSPRNYAKLPAKHTSHNKNDHLQEEDHSGWYHRIENNGWRPVSDTFWLSTDGMVVEDKKESEFHFSKLKRRQDLEKKRKLRKIEWMRQMYYSGSLEAKSTHHETLGLIHTATKGLIRAFEDGGIDSVMEWEVDEVLNWTNTLNFDEYIASWKEIATSNSSANFKGFRFNQAQKNIYNYGGDISKMQMGIPDDTYYENVYQEPNVTRLTPDSTYGL
What is the function of this protein?
Acts as an inhibitor of mitochondrial fission.  Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.
What are the official names of this protein?
Protein MFI, Mitochondrial fission factor interactor.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion outer membrane. Note=Predominantly localizes to the cytosol, with a minor fraction at the outer mitochondrial membrane.
Protein: KDSA_XYLF2
Sequence: MKLCGFEVGLNQPLFLIAGPCVIESLQLQLDTAGVLKEITSKLGLNFIFKSSFDKANRTSGSSFRGPGLEEGLKVLEAVKTQIGVPVLTDVHEYTPIDEVATVVDVLQTPAFLVRQTDFIRNVCAVGKPVNIKKGQFLSPWDMKPVVEKAKSTGNSQILVCERGASFGYNNLVSDMRSLAVMRETGCPVVFDATHSVQLPGAQGGRSGGQREFVPVLARAAVAVGISGLFAETHPDPPNALSDGPNAWPLRTMAMLLETLVELDAVTKKRGFLEQD
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPIH_MOUSE
Sequence: MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIEFQAPLGKRVQAWTHSLTCPALTGILALILMPTE
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.  Participates in pre-mRNA splicing.  May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.  May act as a chaperone.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase H, PPIase H, Rotamase H.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic (By similarity).
Protein: S22A7_HUMAN
Sequence: MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMPMKQVQN
What is the function of this protein?
Mediates sodium-independent multispecific organic anion transport.  Transport of prostaglandin E2, prostaglandin F2-alpha, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
What are the official names of this protein?
Solute carrier family 22 member 7, Novel liver transporter, Organic anion transporter 2, hOAT2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Protein: HOA1_MYCVP
Sequence: MIRDVYLSDVTLRDGMHAVRHQYSIEQVAMIATALDRAGVDSIEVAHGDGLAGGTCNYGFGAHTDLEWIETVATAVKRARVATLVLPGVGTVRDLRDARRAGATVVRVGTHCTEADISAEHITAARELGMDTVGFLMMSHMSSPSALAAQAKLMEGYGATCVYVVDSGGAMVMRDVAERVDALRQTLLPATEIGIHAHHNLSLGVANSITAVQHGAHRVDASLAGMGAGAGNAPLEVFVAAAERLDWTHGCDLHALQDAADDLVRPLQDRPVRVDRETLTLGYAGVYSSFLRHAEAAAARYHIDARTLLEEAGRRGMVGGQEDMLVDIALDLTGADRS
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 1, HOA 1, 4-hydroxy-2-keto-pentanoic acid aldolase 1, 4-hydroxy-2-oxopentanoate aldolase 1.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: RLP46_ARATH
Sequence: MSKQCLLSCFLFFCFFIPQLSFSCPQDQRQSLLEFKNLLIHNIKDNYTAFEELGTWRPNSDCCKWLRVTCNASSPSKEVIDLNLFLLIPPGLVSSSILRPILRINSLVGLDVSFNNIQGEIPGYAFVNLTSLISLDMCCNRFNGSIPHELFSLTNLQRLDLSRNVIGGTLSGDIKELKNLQELILDENLIGGAIPSEIGSLVELLTLTLRQNMFNSSIPSSVSRLTKLKTIDLQNNFLSSKIPDDIGNLVNLSTLSLSMNKLSGGIPSSIHNLKNLETLQLENNNGLSGEIPAAWLFGLQKLKVLRLEGNNKLQWNNNGYVFPQFKLTHLSLRSCGLEGNIPDWLKNQTALVYLDLSINRLEGRFPKWLADLKIRNITLSDNRLTGSLPPNLFQRPSLYYLVLSRNNFSGQIPDTIGESQVMVLMLSENNFSGSVPKSITKIPFLKLLDLSKNRLSGEFPRFRPESYLEWLDISSNEFSGDVPAYFGGSTSMLLMSQNNFSGEFPQNFRNLSYLIRLDLHDNKISGTVASLISQLSSSVEVLSLRNNSLKGSIPEGISNLTSLKVLDLSENNLDGYLPSSLGNLTCMIKSPEPSAMTIRPYFSSYTDIPNIERLIEIESEDIFSLVVNWKNSKQVLFDRNFYLYTLLDLSKNKLHGEIPTSLGNLKSLKVLNLSNNEFSGLIPQSFGDLEKVESLDLSHNNLTGEIPKTLSKLSELNTLDLRNNKLKGRIPESPQLDRLNNPNIYANNSGICGMQIQVPCFPTQTKQPAEEKEEEDKEEEETIFSWNAAAIGCSCGFLIAVVFMSYNELWK
What are the official names of this protein?
Receptor-like protein 46, AtRLP46.
What is the protein family that this protein belongs to?
Belongs to the RLP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ZIP10_ORYSJ
Sequence: MESSSSSSYIPFIRQIAASVSAASCDAVVGGGGDKDEECRDEAAALRLKMVAVAAILIAGAAGVAIPLVGRRRRGGGGGGGGGASSGGLFVLAKAFAAGVILATGFVHMLHDAEHALSNPCLPHSPWRRFPFPGFVAMLAALATLVVDFVGTHFYERKHRQEEAAAAAEEAAAALLEDGGALPVGDGEGRDGRGGKRDAMHIVGIHAHAAAHRHSHAHVHGACHGGAVNDAHAHGHGHGHEEGPSARHVVVSQILELGIVSHSVIIGLSLGVSQSPCTIKPLVAALSFHQFFEGFALGGCISEAQLKNFSAFLMAFFFAITTPAGITVGAAVASFYNPNSPRALVVEGILDSMSAGILIYMALVDLIAADFLSRKMSCNPRLQVGSYIALFLGAMAMAALALWA
What is the function of this protein?
Zinc transporter that may be involved in zinc uptake from the rhizosphere.
What are the official names of this protein?
Zinc transporter 10, ZRT/IRT-like protein 10, OsZIP10.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRVP1_VARAC
Sequence: MILLKLYLTLAAILCQSRGTTSLDLDDLMTTNPEIQNEIINKHNDLRRTVDPPAKNMLKMSWDNIIAESAKRAALRCNQNEHTPVSGRTIGGCGCAEKIT
What is the function of this protein?
Blocks ryanodine receptors, and potassium channels.
What are the official names of this protein?
Cysteine-rich venom protein VAR1, CRVP, Cysteine-rich secretory protein VAR1, CRISP-VAR1.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: TATB_SALTY
Sequence: MFDIGFSELLLVFVIGLIVLGPQRLPVAVKTVAGWIRALRSLATTVQNELTQELKLQEFQDSLKKVEKASLENLTPELKASMDELRQAAESMKRTYSANDPEQASDEAHTIHNPVVKGNETQHEGVTPAAAETQASAPEQKPEPVKANVPESTETASVATIDAEKKSAAPVVESSPSSSDKP
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ARL8A_HUMAN
Sequence: MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKPQLQGIPVLVLGNKRDLPGALDEKELIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
What is the function of this protein?
Plays a role in lysosome motility (By similarity).  In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity).  May play a role in chromosome segregation (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 8A, ADP-ribosylation factor-like protein 10B, Novel small G protein indispensable for equal chromosome segregation 2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Cell projection, axon. Synapse. Note=Localizes with microtubules at the spindle mid-zone during mitosis.
Protein: RL31_YERPE
Sequence: MKQGIHPKYEQVTASCSCGNVIKINSTVGHDLNLDVCGECHPFYTGKQRDVASGGRVDRFNKRFSVPGAKK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: PFMAC_PESFW
Sequence: MSGPALEVAAAKTAEQGQVPVLAAAVRGDTKVSGDSIHAATTAVSDGDNQSSTMSGKTAAGDATSPASGSGSGGWFHWHEPGTSKAEKKLIFKLDWFLLSYSCLCFFIKQLDGNNVTNAYASGMQEQLGFGPGNELSWMNTYFNIGQIIGAPFANMIITVVRPRYWLPACLMTWSAFVLGMYRCETAAQFYVLRFFIGLFEGAAWPGITYTLGCWYRKSEMARRSALFVMSGVLGQMFSGYLQAALYTGMDGKGGLAAWRWLFIFDFILAVPIAIYGLFCFPDTPHKTSAWYLNSWEREKAVERIDSEGRKPIGKLDLSVFKRIFTSWQVYAFTLGYALWSLTVGSYVMQYFTLYLKATKEYTIPQINNIPTALGAVNFVTMLTTGFVSDKIGRRGPVCLAVGCVLIFTYSIFTAWNVPHRLLMAVFILNGVYGCYTPLLAGWVNECCGGDQQKRAFILGLMTSVGGAVVIPFQQLQFPSSQAPQFKQTHGWPSALAFVIALTCWTGLGIPLLQRRMEKQAKRNEAEHEA
What is the function of this protein?
MFS transporter; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment forming a dark layer in the conidial wall that protects the conidia from UV radiations.
What are the official names of this protein?
MFS transporter PfmaC, Conidial pigment biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Allantoate permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNLJ_SALAR
Sequence: MEPIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRALEAQRPDLITPDSPTQRVGAAPLTAFNQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKSTENVTWCCELKLDGLAVSILYENGVLVRAATRGDGTTGEDITSNVRTIRAIPLKLRGDNIPARLEVRGEVFLPQAGFEKINEEARRSGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGILEGGELPDTHLGRLLQFKAWGLPVSDRVTLCDSPQAVLAFYHNVEEDRPTLGFDIDGVVIKVNSLALQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVQVAGVLVSNATLHNADEIDRLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEETRPIVFPTHCPVCGSDVERVEGEAVTRCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEREYVHTPADLFRLTAGKLTGLDRMGPKSAQNVVNALEKAKATIFARFLYALGIREVGEATAAGLAAYFGTLEALQAASIDELQKVPDVGIVVATHVFNFFAEESNREVIGQLLAEGVHWPAPVVINAQEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIDVIDEAEMLRLLGV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ARRD3_HUMAN
Sequence: MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
What is the function of this protein?
Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550).  Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550).  May recruit NEDD4 to ADRB2 (PubMed:20559325).  Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550).
What are the official names of this protein?
Arrestin domain-containing protein 3, TBP-2-like inducible membrane protein, TLIMP.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Endosome. Early endosome. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:20559325).
Protein: SSRP_RHOP5
Sequence: MAEKNERPIKVVAENRKARFNYAIEDTVEAGIALTGTEVKSVRNGKTTIAESYADSRGGEIWLINANIPEYLQANRFNHEPKRPRKLLLHRKQINKLMGAVERQGMTLIPLKLYFNEKGRAKLLLALAKGKQLHDKRETEKKRDWSKEKGRLMRAKG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: IGW4_HETFR
Sequence: EDNLSDLEGKEEAGDWDGDDNVLTVAAFAILFILSFLYSTFVTVVKVQQ
What are the official names of this protein?
IgW transmembrane form Tm2T7/Tm7T7/Tm3T3.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TBL16_ARATH
Sequence: MNETFSATPRSMTIHRYRMKRGALRRRARDISVMLVVLVCATVVIWTWDRTPTSAFLPPESHYLKLQSEEKVEKLPTALNTETKDSYSSAIPFVNKEESKEDSSDNKDTEEEEEKQVEEVTVSNTNRGKIPTIEEKKGEHEVIASEPKYRKTPTREDFKLEKVKHEVAVGEGEATETTHIKETNSDPKSNILATDEERTDGTSTARITNQACNYAKGKWVVDNHRPLYSGSQCKQWLASMWACRLMQRTDFAFESLRWQPKDCSMEEFEGSKFLRRMKNKTLAFVGDSLGRQQFQSMMCMISGGKERLDVLDVGPEFGFITPEGGARPGGWAYRFPETNTTVLYHWSSTLCDIEPLNITDPATEHAMHLDRPPAFLRQYLQKIDVLVMNTGHHWNRGKLNGNKWVMHVNGVPNTNRKLAALGNAKNFTIHSTVSWVNSQLPLHPGLKAFYRSLSPRHFVGGEWNTGGSCNNTTPMSIGKEVLQEESSDYSAGRAVKGTGVKLLDITALSHIRDEGHISRFSISASRGVQDCLHWCLPGVPDTWNEILFAMI
What is the function of this protein?
May act as a bridging protein that binds pectin and other cell wall polysaccharides.  Probably involved in maintaining esterification of pectins (By similarity).  May be involved in the specific O-acetylation of cell wall polymers (By similarity).
What are the official names of this protein?
Protein trichome birefringence-like 16.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: LST2_DROPE
Sequence: MICCEIQQKSHKKNKPQPDDKSLLARFFHADRSLTAVASELDSFDGRAEPDRCSRLVSRLRQNQDKVLSITNLIMEELLGEDRDPRAFRAKFPEEVLQENLAGQLWFGAECLAAGSSIMNREVESKEMRPLAQAVTKSLGNVRVLLRDQCLRNNVPNSKTLHLDLNDYTTEQLYESLKIFDRLFAEFELSYVSAMVQVKSRHEYEMQQWIGVLFSETLQRALKIGLLDQDMVDAFDPGLMFSIPRLAIVAGLVVYAKGPLDMDMPGDQLSEMFRPFRTILIKIRDLLRNLNNQELYQLEKLLCTNEDINTKVPVGSSSIEAPTPEHSSTPTTSSNNNNNNKSSSSSSGTGSGSGAGTVERLVDQRNNNNNQQNSNESTTLPPRSPSMLSLSASSTPTASPAPSPTPSHSIASTTSSAASSNSTHPPADWSDGDDEDEDEEEDEEEDELEDTEDDTDEEQLLKDIVAADCASGYLIPNTNLGNLLQPQQVPLTDNFVASEDDDEYGTGDQQQEQPQQQGHRKEDEEEPSTSAALQRLRLASSDDSEPHRDQGETIKSTEEQEQQQQQQEQQTLQSSRQRHSHSHSHSHRHHHRHHHHHHHSTHQQQLQHQPHHHQPHPHRLTRSGRKRCSMEAAVEVEQQEQGLASGDTSAASSLSDDVSLAMRNTTARLKFNTENLLHRLFVCIAGVADQLQTNFASDLRQILRSVFLMNMSSVEEEQIEIPEKTKESELFEFRASENDVIQESAGSNQSIYSAEEVNPELDNVFSAGSRHSAGATMQRNNTIDNPSSSNTSSSSATTRNHVTRSRSLGDQETIARSMPAPVHQQEQEMQQQQDHQQQQHQHQVQVQLQRQRNNSVGSNTPSSASSTSSSSEQNSPVSTRSGSSRRRLQSNNETQMPSSTSTATAAATLAPPAWIPDGKAPRCMSCQTPFTAFRRRHHCRNCGGVFCGVCSNATAPLPKYGLTKAVRVCRDCYVREVQVRSSSTTTSVSVNVGVQMQSQAGRVQTATAS
What is the function of this protein?
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
What are the official names of this protein?
Lateral signaling target protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the lst-2 family.
Protein: RNT_HAEDU
Sequence: MTEQVTDHNLLKHRFRGYLPVIIDVETAGLNAKTDALLELAAITVKMDQQGYLVPDQKCHFHIQPFENANINADSLKFNGIDIHNPLRGAVAEAIAIPEMFKMVRRAIKEQGCQRAVIVAHNATFDQAFLQAAVKRINAKRDPFHPFAMFDTASLAGLMYGQTVLVKACQIANIAFDGKQAHSALYDTEKTTELFCAMVNRLKDLGGFPLLNPK
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.