PharMolix/UniProtQA huggingface dataset:
Protein: PHOSP_HRSVA
Sequence: MEKFAPEFHGEDANNRATKFLESIKGKFTSPKDPKKKDSIISVNSIDIEVTKESPITSNSTIINPTNETDDTAGNKPNYQRKPLVSFKEDPTPSDNPFSKLYKETIETFDNNEEESSYSYEEINDQTNDNITARLDRIDEKLSEILGMLHTLVVASAGPTSARDGIRDAMIGLREEMIEKIRTEALMTNDRLEAMARLRNEESEKMAKDTSDEVSLNPTSEKLNNLLEGNDSDNDLSLEDF
What is the function of this protein?
Plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins (PubMed:26474524, PubMed:25568210).  Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex (PubMed:26474524).  Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA (PubMed:26474524).  Acts as a chaperone for neo-synthesized nucleoprotein by forming an N-P complex that preserves N in a monomeric and RNA-free state and prevents the association of nascent N with host cell RNAs (PubMed:25568210).  Recruits the host phosphatase PP1 to inclusion bodies to regulate viral transcription (PubMed:29489893).  Together with the nucleoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (By similarity).
What are the official names of this protein?
Phosphoprotein, Protein P.
What is the protein family that this protein belongs to?
Belongs to the pneumoviridae phosphoprotein P family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Localizes in cytoplasmic inclusion bodies.
Protein: VL1_HPV62
Sequence: MAMWRPGDGKVYLPPTPVSKVLSTDTYVTRTNLFYYGGSSRLLTVGHPYCTLQVGQGKRATIPKVSGYQYRVFRVKLPDPNKFTLPDATLYNPDTERMVWACRGIEVGRGQPLGVGTSGHPLYNRLDDTENTSLLAAANDDSRDNISVDYKQTQLLIVGCKPPIGEHWTKGTLCPNAAPAPTECPPLEFKNTTIQDGDMVETGYGAIDFKSLQESKSEVPLDICTSTCKYPDYLQMAAEPYGDCMFFCLRREQMFARHFFNRHGTMGEALPTDLYMKGTPGSDRQMPGSYIYAPTPSGSMVSSDSQLFNKPYWLQRAQGHNNGICWFNELFVTVVDTTRSTNFTICTASTAAAEYKATNFREFLRHTEEFDLQFIFQLCKIQLTPEIMAYLHNMNKDLLDDWNFGVLPPPSTSLDETYHYLQSRAITCQKGAASPSPKVDPYAQMTFWTVDLKDKLSTDLDQFPLGRKFLLQAGSRPRSVAVSRKRSAPTKQSPTSAKRKRRK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: LEUC_CORGL
Sequence: MTSPVENSTSTEKLTLAEKVWRDHVVSKGENGEPDLLYIDLQLLHEVTSPQAFDGLRMTGRKLRHPELHLATEDHNVPTEGIKTGSLLEINDKISRLQVSTLRDNCEEFGVRLHPMGDVRQGIVHTVGPQLGATQPGMTIVCGDSHTSTHGAFGSMAFGIGTSEVEHVMATQTLPLKPFKTMAIEVTGELQPGVSSKDLILAIIAKIGTGGGQGYVLEYRGEAIRKMSMDARMTMCNMSIEAGARAGMIAPDQTTFDYVEGREMAPKGADWDEAVAYWKTLPTDEGATFDKVVEIDGSALTPFITWGTNPGQGLPLGESVPSPEDFTNDNDKAAAEKALQYMDLVPGTPLRDIKIDTVFLGSCTNARIEDLQIAADILKGHKIADGMRMMVVPSSTWIKQEAEALGLDKIFTDAGAEWRTAGCSMCLGMNPDQLKPGERSASTSNRNFEGRQGPGGRTHLVSPAVAAATAIRGTLSSPADI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: EZRA_STREM
Sequence: MSSGLILLIVAIVLLVIIAYLVGVIIRKRNDTLITSLEERKQALFGLPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLTLNTFTDIEKHIFEAEHLNDTFNFIRAKHEINSVESQLNLVEEDITAIREALGILKEQEEKNSARVTHALDLYEKLQASVAENEDNFGSTMAEIEKQMKNIEAEFSQFVALNSSGDPVEAAEVLDKAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLETGYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRARDENTHIQERIDSLYELFEREIAAYKVVAKNSKILPRYLAHAKHNNEQLKHEIARLSRKYILSENEGLNIKAFDKDLKDIEDNVLEIAEAFDQQEKPFSELQLILDRSIKTLASVESGQMDVFAAVKDIEKIESQARQHLEIYVTQLHMIKRYMEKRNLPGIPQDFLSTFFTTSSQLEALMDELSRGRINIEAVSRLSEVATAAIANLEELTYQVVQHATLTEQLLQYSNRYRSFEAGVQNSFEHALKLFEVDNDYQASFDEISYALETVEPGVTERFVNSYEKTRERIRF
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: PSD_LEGPL
Sequence: MFRDVLKTLPQYLIPKHGITALAGYFADVKNPRLKNFLIRNFIRKFDVDMSEALIEDPKSYDCFNDFFIRHLKPECRPLSQSDVICPVDGCISEIGKIERGQLLQAKGKYYSVQELLACDGQLAEQFVQGQFATLYLSPKDYHRVHMPIDAELVSMTYIPGALFSVQPATTRVVPKLFARNERLAIFFKTKIGPMVMVMVGATIVGAIGTSWHGDVKRSKKLERFDYSEQFSDKIISQGSEMGYFKLGSTVVLLFANGEKIQWDKELLAGSKIQLGKPMAIIT
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ATPH_PORPU
Sequence: MDSIVSAASVIAAGLAVGLAAIGPGIGQGSAAANAVEGIARQPEVEGKIRGTLLLSLAFMESLTIYGLVVALSLLFANPYVG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PNP_ECO45
Sequence: MLNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGQKKAKPGQDFFPLTVNYQERTYAAGRIPGSFFRREGRPSEGETLIARLIDRPIRPLFPEGFVNEVQVIATVVSVNPQVNPDIVAMIGASAALSLSGIPFNGPIGAARVGYINDQYVLNPTQDELKESKLDLVVAGTEAAVLMVESEAELLSEDQMLGAVVFGHEQQQVVIQNINELVKEAGKPRWDWQPEPVNEALNARVAALAEARLSDAYRITDKQERYAQVDVIKSETIATLLAEDETLDENELGEILHAIEKNVVRSRVLAGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGETQALVTATLGTARDAQVLDELMGERTDTFLFHYNFPPYSVGETGMVGSPKRREIGHGRLAKRGVLAVMPDMDKFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKEGDNYVVLSDILGDEDHLGDMDFKVAGSRDGISALQMDIKIEGITKEIMQVALNQAKGARLHILGVMEQAINAPRGDISEFAPRIHTIKINPDKIKDVIGKGGSVIRALTEETGTTIEIEDDGTVKIAATDGEKAKHAIRRIEEITAEIEVGRVYNGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVTDYLQMGQEVPVKVLEVDRQGRIRLSIKEATEQSQPAAAPEAPAAEQGE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_STAHJ
Sequence: MAGQVVQYGRHRKRRNYARISEVLELPNLIEIQTKSYDWFLKEGLLEMFRDISPIEDFTGNLSLEFVDYRLGEPKYDLEESKNRDATYAAPLRVKVRLIIKETGEVKEQEVFMGDFPLMTDTGTFVINGAERVIVSQLVRSPSVYFNEKIDKNGRENYDATIIPNRGAWLEYETDAKDVVYVRIDRTRKLPLTVLLRALGFSNDQEIIDLLGDSEYLRNTLEKDGTENTEQALLEIYERLRPGEPPTVENAKSLLYSRFFDPKRYDLASVGRYKANKKLHLKHRLFNQRLAEPIVNSETGEIVAEEGTVLDRRKLDEIMEVLETNANSEVFELEGTVIDEPVEIQSIKVYVPNDEEGRTTTVIGNALPDSEVKCITPADIIASMSYFFNLLNGIGYTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTDSITPQQLINIRPVIASIKEFFGSSQLSQFMDQANPLAELTHKRRLSALGPGGLTRERAQMEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSYARVNEFGFIETPYRKVDLDTNSITDQIDYLTADEEDSYVVAQANSRLDENGRFLDDEVVCRFRGNNTVMAKEKMDYMDVSPKQVVSAATACIPFLENDDSNRALMGANMQRQAVPLMNTEAPFVGTGMEHVAARDSGAAITAKYRGRVEHVESKEILVRRLVEENGTEHEGELDRYPLAKFKRSNTGTCYNQRPIVSVGDVVEYNEILADGPSMELGEMALGRNVVVGFMTWDGYNYEDAVIMSERLVKDDVYTSIHIEEYESEARDTKLGPEEITRDIPNVSENALKNLDDRGIVYVGAEVKDGDILVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGAGGIVLDVKVFNREEGDDTLSPGVNQLVRVYIVQKRKIHVGDKMCGRHGNKGVISKIVPEEDMPYLPDGRPIDIMLNPLGVPSRMNIGQVLELHLGMAAKNLGIHVASPVFDGANDDDVWSTIEEAGMARDGKTVLYDGRTGEPFDNRISVGVMYMLKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDTVGRVKTYEAIVKGENISRPSVPESFRVLMKELQSLGLDVKVMDEQDNEIEMADVDDEDATERKVDLQQKDVPETQKETTD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: ERA_EHRCR
Sequence: MDHISKKCSMNAIVGTTNAGKSTLINMLVGQKVAAVTPKVQTTRVRMHAVLNNENVQLIFIDTPGIFSPKTKLEKFIVKHAWMSLKGIENVILLLDVKNYLNKHIEKIISRIKQSNINAILVVNKIDTVPTSSVDKAIEHMYSLHSFSKTFTISALHDIGLSRLVDYLCEISPNGPWLYPEDQISDAPLKFFMAEITREKLFLSLHHELPYSLSVVTEALEEKEDGSLVVKQVIYVTKDSHRTIILGKKGEMIKKISMESRSDLAKILDLKIHLFLFVKVREFWQNHLDECVGYVE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: RL6_PROMP
Sequence: MSRIGKSPVQIPEKVSVDIKGLSITVKGPKGELKRLMPEGVNFDQKENQIVVTPATTKRYSRERHGLCRTLISNMVQGVTEGYEKKLEIVGVGSRAQVKGKNLVVSAGYSHPVEMTPPDGITYKVESNTNVTVSGIDKEIVGNEAAKIRSIRPPEPYKGKGIKYQDERIIRKAGKSGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RS20_BIFAA
Sequence: MANIKSQKKRVLTNEKAHKRNVAVKSSLKTAVRATREAIAAGDKAAAEAAYKVAAQKLDKAAGAGVIHKNQAANRKSGLAVAINAL
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: SDHL_MOUSE
Sequence: MAAQESLHVKTPLRDSMALSKLAGTSVFLKMDSSQPSGSFKIRGIGHLCKMKAKQGCRHFVCSSAGNAGMATAYAARRLGIPATIVVPNTTPALTIERLKNEGATVEVVGEMLDEAIQVAKALEKNNPGWVYISPFDDPLIWEGHTSLVKELKETLSAKPGAIVLSVGGGGLLCGVVQGLREVGWEDVPIIAMETFGAHSFHAAIKEGKLVTLPKITSVAKALGVNTVGAQTLKLFYEHPIFSEVISDQEAVSALEKFVDDEKILVEPACGAALAAVYSRVVCRLQDEGRLQTPLASLVVIVCGGSNISLAQLQALKVQLGLNGLPE
What are the official names of this protein?
L-serine dehydratase/L-threonine deaminase, SDH, L-serine deaminase, L-threonine dehydratase, TDH.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPB_BRADU
Sequence: MNIEKYTERSRGFIQSAQSLAVREGHQQFSTLHVLKVLLDDNEGLAAGLIDRAGGNSRAILKATEDALNKVPKVSGGGAGQIYLAPELARTFDAAEKAGEKAGDSFVTVERLLLGLTLEKTSEAGTILSKGGVTPQNLNAAIEALRKGRTADSATAENAYDALKKYARDLTQAARDGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIAEGLALRIVNGDVPESLKDKKLLSLDLGALIAGAKYRGEFEERLKAVLQEVTGSEGTFILFIDEMHTLIGAGKGDGAMDASNLLKPALARGELHCIGATTLDEYQKHVEKDAALARRFQPIFVSEPSVEDTISILRGLKDKYEQHHGVRITDSALVASATLSNRYITDRFLPDKAIDLMDEAAARLKMQVDSKPEELDSMDREIIRLKIEQEALKKESDAGSKSRLQTLEKELVELEEKSASLTARWSAEKNKLSDAQKLKAELDGLRVELANAQRRGEFQKAGELAYGRIPELERQLADIEAKENSGEMMEEAVTANHIAQVVSRWTGVPVDKMLEGEKDKLLKMEDSLGKRVVGQAEAVHAVATAVRRSRAGLQDPNRPMGSFMFLGPTGVGKTELTKALAEYLFNDETAMVRLDMSEYMEKHSVSRLIGAPPGYVGYDEGGALTEAVRRRPYQVVLFDEIEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFRNTLIIMTSNLGSEFLVNQPEGEDTSAVREQVMGMVRGHFRPEFLNRVDEIILFHRLQRSEMGRIVEIQFARLQKLLTDRKIVLTLDGAARDWLAAKGWDPAYGARPLKRVIQRYLQDPLAEMILAGDVKDGDNVAISSEGNVLTFNGKAPQTAEIAQFEAPASKRKLN
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_RALPJ
Sequence: MNLNATLVAQMVVFFILWWVVAKFIWPPLVKALDERAKKIADGLAAADKGKAELELANKRVDQALTEARNEGAQRIADAEKRAQMTADEIKQNAQAEAARIIAQAKAEAEQQTVRARESLRDQVAVLAVKGAEQILKREVNAQVHADLLNQLKAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RNH_RICCN
Sequence: MDSKVVIYTDGACAGNPGPGGWGALLQFNDTSKEVFGYELDTTNNRMEITAALEALRILKKSCNIEIYTDSKYLQQGITAWIHNWIKNNWCKSNNEPVKNADLWQKLYAELSKHTIIWKWVKGHANNSGNIAADKLAVQGRETAIEILKCRG
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HI, RNase HI.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAN3_CHATD
Sequence: MAPLDLTRGQTDACSTENKDILCRNVLIYGHCRYEDQGCTYNHDQNKNSSQPEAPSKKMFNVDSPSFTPSGQSTVLPKKTTLSSQAASAAPFTPRGGGTPTLQTTAESTMFNPAAIREFTPQNYDLGNNNANGISQENGLYPDPFTMSTMGTALPTAGQYNLPLYGDHSGLAAPGAPFYPPHAAYPTGPIQPPHYHLYQPFGPYRQELQPWQRATYDFFMPQNLREDLQKKQFATLQVIPNSGLPQLEHWHSLVPLDTSNRKNTSCFGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVVELQQEDFVKFGKLILSLATGTLPAHLNNIPAALETLGNKYSANLKSAVNWLLDTSSGETKTIEHFMTGIASQMTTFFDLALQDNDEKLFHLAREVENGRIARSLMKLLTILERGDYDGVPSWSETGDRYQLKLFRDYVFHRVDADGKPNLSIGHMLTCMSKLEAGVDENILLTSRDNETVFVLSYRELRQMYDRAFNELVKASKTGAPGANT
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.  PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit PAN3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRGM2_CYPCA
Sequence: MKVTFYEDRNFQGRSYDCMSDCADFSSYMSRCHSCRVHSGCWMMYDQPNYMGNQYFFRRGEYADYMSMFGMSNCIRSCRMIPMHRGSYRMRIYERENFMGQMYEMADDCDSIMDRYRMPHCQSCHVMDGHWLMYEQPHYRGRMWYFRPGEYRSFSNMGGMRFMSMRRIMDSWY
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin M2, Gamma-M2.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: DNLZ_MOUSE
Sequence: MLRTALSRMPTLLRSVRTRDSGPRRLWDLGARLKTAERLRGWAWGWASGWRSSSSAPGSGRAAALGRVEADHYQLVYTCKVCGTRSSKRISKLAYHQGVVIVTCPGCQNHHIIADNLSWFSDLKGKRNIEEILAARGEEVRRVSGDGALELILEAAVPPDTPEGDEDPPNPGKMGQS
What is the function of this protein?
May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.
What are the official names of this protein?
DNL-type zinc finger protein, Hsp70-escort protein 1, HEP1, mtHsp70-escort protein.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GLNE_SALCH
Sequence: MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: DXS_METFK
Sequence: MYELLESINSPEDLRRLDRKELHELARQLRAFLINSVAQTGGHLSSNLGVVELTIALHYVFNTPEDRVVWDVGHQTYPHKILTGRRKDMGNLRRPGGIAGFPRRDESIYDTFGTGHSSTSISAALGMAVAAQKTGSDRHSIAVIGDGAMTAGMAFEALNNAGAMDANILVILNDNDMSISPNVGALTNYLAKLLSGPLYTTVRRSGEKVLGVVPPVREFAKRAEEHVKGMVTPGTLFEEFGFNYIGPIDGHDIDVLITTLRNIRELKGPQFLHIATQKGHGYQPAEDNPGKFHGVGKFDPSNGCSIAQAGKKTYTQVFSDWLVDMAARDERLVGITPAMCDGSGLNAFAEQFPDRFFDVGIAEQHALTFAAGMACDGLKPVVAIYSTFLQRAYDQFIHDIALQNLPVMFAIDRAGLVGADGPTHAGSFDLSYLRCIPNIIIMAPSDENECRQMLYTAYLHDGPSAVRYPRGGGPGATITRDMQLLPIGKGELRRQGSWVAILAFGSMLAPALEAAETLDATVANMRFVKPLDANLINQLASSHTLIVTVEENAVMGGAGAAVMECMQAADIHTPVLCLGLPDMFIEHGVHETMLAECGLNAAGIIAAIEKKLTK
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: DBP9_ASPOR
Sequence: MKRKLDANDVPSPEAADKKEKKEEDDADFESLNLDPRLRQALIKEKFTKPTLVQAKAIPLALEGKDILARAKTGSGKTAAYVLPILQTILQKKATDPSFKATTGLILVPTRELAEQVQNVVTTFAAFCGKDVRSVNLTQKVSDAVQRTMLADYPDLVVSTPARVVTNLGSSALSLENLTHLVIDEADLVLSYGYEEDINALAKAIPRGVQTFLMSATLTDEVDTLKGLFCRSPVTLKLEDKDDQGAGVSQFVVRCAEDEKFLLTYVIFKLQLIKGKVIIFVDDVDRCYRVKLFLEQFGIKSCVLNSELPINSRIHVVQEFNKGVYDILIAADEQEVIGARKSKKSKETEEAGSSDEDEGEPEDKSKRRKVSGKEKDYGISRGIDFQNVACVLNFDLPSTSKSYTHRIGRTGRAGKTGMALSFVIPKDQHGKHRPTSTATSKHDESVLAKIVKRQGKLGHEVKPYHFEMKQVEAFRYRMTDALRAVTRLAVQEARAREIRQELIKSEKLKRHFEENPEELRQLRHDDELRSARVQPHLKHIPEYLMPAKGKKGLSSGDVGFVSFRKQNENRIRKAREKNRGKGNGRKFAGVKKKVDPLKTFNRGRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase dbp9.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HIS81_LEGPA
Sequence: MSILNLVRTDLLNSQNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQNQLAKRYQIYSDQIILTRGSDDGIDLTTRFFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLVDLNLIAKTCELYANQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPYSIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTRFSKQLTTWLARYGIAVRDFPSSSLLHDHLRITVGNDEQNQLLINALSSFNADVAGLNYEKDFIY
What are the official names of this protein?
Histidinol-phosphate aminotransferase 1, Imidazole acetol-phosphate transaminase 1.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: YFBO_ECOLI
Sequence: MTPLERITQLVNINGDVNNPDTPRPLLSLEDFFIDNNIHGSICCNVIPEQSPQAIYHHFLKIRERNNVSDVLVEITMFDDPDWPFSESILVITTASPEEVQSWFVEEIAPDECWEGWSEDTEHGWVEVPVGMHPVTCWWD
What are the official names of this protein?
Uncharacterized protein YfbO.
Protein: OXDA_HUMAN
Sequence: MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
What is the function of this protein?
Regulates the level of the neuromodulator D-serine in the brain.  Has high activity towards D-DOPA and contributes to dopamine synthesis.  Could act as a detoxifying agent which removes D-amino acids accumulated during aging.  Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups.  Does not act on acidic amino acids.
What are the official names of this protein?
D-amino-acid oxidase, DAAO, DAMOX, DAO.
What is the protein family that this protein belongs to?
Belongs to the DAMOX/DASOX family.
What are the subcellular locations of this protein?
Peroxisome.