PharMolix/UniProtQA huggingface dataset:
Protein: TRPB_RHOP2
Sequence: MNQILPNSFRSGPDERGHFGIFGGRFVAETLMPLILALEKAYAEAKDDPAFRAEMDGYLKHYVGRPSPLYFAERLTEHFGGAKIYFKREDLNHTGAHKVNNVLGQIMLARRMGKPRIIAETGAGMHGVATATMCAKFGLQCVVYMGAVDVDRQQPNVLRMKALGAEVRPVTSGAATLKDAMNEALRDWVTNVHDTFYCIGTVAGPHPYPMMVRDFQAVIGQEVRAQIMEAEGRLPDSLIACIGGGSNAMGLFHPFLDDSSVAIYGVEAAGHGLSKLHAASIAGGKPGVLHGNRTYLLMDTDGQIQEAHSISAGLDYPGIGPEHAWLHDVGRVEFMSATDTEALDAFKLCCRLEGIIPALEPAHALAKVGDLAPPLPKDHVMVLNMSGRGDKDLASVAEHLGGQF
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: ACCA_CHLCV
Sequence: MELLPHEKQVVEYEKTIAEFKEKNKKNSLLSSSEIQKLERRLDKLKEKIYSDLTPWERVQICRHPSRPRSVNYIEGMCEEFVELCGDRTFRDDPAVVGGLAKIQGQRFMLIGQEKGCDTASRVHRNFGMLCPEGFRKALRLAKMAEKFGLPIVFLVDTPGAFPGLTAEERGQGWAIANNLFQLARLKTPIIVLVIGEGCSGGALGMAIGDVIAMLEHSYYSVISPEGCASILWKDPKKNSEAAAMLKMHGEDLKQFAIVDVVIKEPVGGAHHDPAAVYRNVQNFILQEWLRLKDLSIEDLLEKRYQKFRTIGLYETSSESGPEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEAD_ECOLI
Sequence: MIKKIFALPVIEQISPVLSRRKLDELDLIVVDHPQVKASFALQGAHLLSWKPAGEEEVLWLSNNTPFKNGVAIRGGVPVCWPWFGPAAQQGLPAHGFARNLPWTLKSHHEDADGVALTFELTQSEETKKFWPHDFTLLAHFRVGKTCEIDLESHGEFETTSALHTYFNVGDIAKVSVSGLGDRFIDKVNDAKENVLTDGIQTFPDRTDRVYLNPQDCSVINDEALNRIIAVGHQHHLNVVGWNPGPALSISMGDMPDDGYKTFVCVETAYASETQKVTKEKPAHLAQSIRVAKR
What are the official names of this protein?
Putative glucose-6-phosphate 1-epimerase, Putative D-hexose-6-phosphate mutarotase, Unknown protein from 2D-page spots T26/PR37.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate 1-epimerase family.
Protein: HLDE_SALPC
Sequence: MKVNLPAFERAGVMVVGDVMLDRYWYGPTCRISPEAPVPVVKVNTVEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKTLAEVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALGSIGALVLSDYAKGALTSVQTMISLARQAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVAGKCKSEDELVERGMKLIADYDLSALLVTRSEQGMTLLQPNKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNTLEEACYFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELRQAVASARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGESRPVNPLEQRMIVLGALESVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSEEVWANGGEVMVLNFEDGCSTTNIIKKIQTESEK
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: GSM1_YEAS8
Sequence: MTKKLPSELKQTRKSIQTACEFCHTKHIQCDVGRPCQNCLKRNIGKFCRDKKRKSRKRIEKHGTQPYLNLGKRLVIHDVPSKTVSPSSVHLQRDFLSSDQEKPGKTPAHNTNIQYTYNINDNFQSAGSIPRITNFNTNNGQTVLENTSNNISASQAVHLMNDPIIPTVRKSTLNLKSHFLEQHKAMQQPLATNCLVATSNVPVHSGMDDSNKSDDDVDDETNIHFDSMWCNDEYMKLKDIVDISTPFLPNNSQIFSLQESEYPNPSASTRGNSSLHLTNLLNSTKSVNDQKDSSIGHSTSTFNTYDEVVSRPFISLDMLHLNRGANANTHPSHNAKLESECDSSSHSDADLEKHDTDFISPSKFRELVKTPQDLYDNKCLIKPHNYKLAYTKLLTTLRKKFLEGAEIDKSASVKDEHSTQKHNLRYDLEVIIRSILERYAPIFISLTSNMIEEDLLLQEVTLQRALLDLENMAKLVSCTPMCIWRRSGEICFVSNEFYSLTGFNKNLLLDRTSFIFEYLDHKSVSNYFQIFNELLAFGYNDINKRKKLLMLNACSSTSSKITEGFSFTTDGKAIFTKCNLLLSNGLYLKCACCWTVKRDSFNIPILVMGQFLPIFEMD
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Binds specifically to 5'-CGGN(8)CGG-3' and 5'-CGGN(9)CGG-3' sequences in the promoter region (By similarity).
What are the official names of this protein?
Glucose starvation modulator protein 1.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SNAPN_ZYGRC
Sequence: MQRHESGNTESNVVHPAELIVYSLLSNDLDGIYQSINDLRESQALLILMLRKIKNSLKEETQLLYDKSNWKDDNERLDSLRKRVDSLKSRFQSLKLRSDKLEQRE
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit SNN1, BLOC-1 subunit SNN1, SNAPIN-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SNAPIN family.
What are the subcellular locations of this protein?
Endosome.
Protein: SYI_FRATH
Sequence: MSDYKDTLNLPKTSFSMKGNLANKEPMILNKWEKQGIYKKIREHFAGREKFVLHDGPPYANGSIHVGHAVNKILKDIIIKSKTLSGYDAPFTPTWDCHGLPIELQVEKKHGKAGQSISEDDFRKECRKYAKKQVEIQKKDFKRLGVLGDWEQPYLTMNFDYEANMIRTLAKIIENGHLSKGFKPVHWCTDCGSALAEAEVEYADKVSPAIDVKFKIKDKDKLAQAFGLDSLNHDAFAIIWTTTPWTLPANQAIAVNNQLNYSLIKIEDFYIILAENLVEQTLKRYAIENAQIIATTTGNKLTGIIAEHPFYSRHVPILHGDHVTDDSGTGLVHTAPTHGVDDFTLGKEHNLSMEIFVKGNGCYSENTKLFAGEFIFKASDRIIELLGEKKRLMNSDKIKHSYPHCWRHKTPLMFRATPQWFISMEKQGLRDKALQTIKETSWAPSWGQARIEGMVKDRPDWCISRQRTWGVPLPLFIHKETEELHPNTIEILHKVAEKIEKDGIEAWFNADDCEFITETAQYKSVKDTLDVWFDSGSSSMCILDLDKRLSYPADLYLEGSDQHRGWFQTSLLVAMSAKGSQPYKEVFTHGFVVDEHGRKMSKSLGNVTSPQDIYNTLGADILRLWTASTDYKSEMAVSDQILKRTADTYRRLRNTARFLLSNLDGFNPVTDIIEFDKLVKLDQWAIAKTKEFQDKIIEAYDKYQTHTVAQLIHHFCSIEMGSFYLDIIKDRQYTAKTDGHPRKSAQTAIYHIVHALVRWMAPILSFTADEIWDATPKTTDLPIQLCEWYTGLKSFDQDAELDLEYWAKIQEIRSEVNRVLEIKRNEDVIKASLEAEITIYADKYNYKLLEKLGNELRFLLISSKADLKVIEESTSSSIAANILGLLIEITKIEEPKCERCWHRSSTVGDNPQYKDICSRCVENITTEAGESREFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAFA_DANRE
Sequence: MATDLAMSAELPNSPLAIEYVNDFDLMKFEIKKEPPEADRYCHRLPPGSLSSTPISTPCSSVPSSPSFCAPSPGSQPGQNLVNGVNNNNNNSGNGNNNTQGSSGKPQMEDLYWIPNYQHHISPEALNLTPEDAVEALIGNAHHHHHHHHHQPYEGFRGQQYVGEDLSAATNGHHHPVHHHHHHHGHHAHARLEDRFSDEQLVSMTVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRYKRVQQRHMLESEKCTLQSQVEQLKQDVARLIKERDLYKEKYEKLASRAFNGGGNTRDPSSGNHVKTTSTDFFM
What is the function of this protein?
Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes (PubMed:11134968).  Specifically binds to the alphaCE2 enhancer element of crystallin gene (PubMed:11134968).
What are the official names of this protein?
Transcription factor MafAa, Somite Maf1, SMaf1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Maf subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPT_RALSO
Sequence: MHISSTLAVPDTADTPHHVAIIMDGNGRWATERHLPRMAGHSRGLDAVRAAVQAADHRGVRYLTLFAFSSENWRRPAEEISFLMKLFMTALRREVSKLNDSGIRLRVVGDLSAFSPRIQLMIREAEAKTATNPGLTVTIAANYGGRWDILQAMRALVADQPDIAPEAITEEALSPYMALAYASEPDLFIRTGGEQRISNFMLWQLAYSELYFTERYWPDFDAAEMDRAFAWYRNRERRFGRTSAQLEPGTAPALSAGA
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: HELI_ICHVA
Sequence: MDVEIKEYAGFVQNEWVRGVASLWMTHPGDGAIVLSGDAGCGKSHAVGQLIEAFSRMGFAECVNITATTHKAVGVLKQPSCTTYQSSLMASIDMCQANFEEFKCLFDARHRQAIEMWDRIVSNRTGLAAVKKGHSCVTLNMRCPVCVATIHESIRCTDKPYPYFIARTMFIIDEYGILSELSLKKILYALSKFKLPGQGYILVFTGSVSQLPSPEHPQIWQTPLLRDMIINTYSLFINFRVEDAAYAEAINLFQFNVITRPAVEMLNARVIGANAVDAEYCDSVTRIFNGNRERDAYNTRHTMVMEGRGAGRVDLTPVIEHVGGSASCRFGALIEYMCSTVPKIFNKATKGKRTVYEGGYVFVLPTQERYTFFGLDDVNTAVVGREDGRLYLERQITKYKGWTVSFFPIFPVAAINTYSAQGETLDRVIYAPPEKNYSMSSIRASAYVACTRVRTRTAIELSCNSFAKSVGRTNMFPEKLLNHKKSVEMGYVPRECPY
What are the official names of this protein?
Probable ATP-dependent helicase 25.
Protein: RL10_LIMRD
Sequence: MSEAAIAKKAEIVKQTTDMLNAAQSAIVVDYRGLTVAEVTDLRKQLRDAGIQMSVIKNKILDRAVEGTDYEDLRSTFVGPTAVAFSDEDPIAPAKILKKFADDHDALEIKGGFIEKSVKTLDEINEYANMPGREELLSMLASALQDPMRKIARAVKAIADKEDEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: FETP_XANOM
Sequence: MSRTVFCHYQQSDAEGLDFVPYPGELGQRIFAHIGKTAWQAWLAHQTMLINENRLSPRDPKHRAFLETELQKFLFERNADKPDGYVAPLGEE
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: NADC_HELPY
Sequence: MEIRTFLERALKEDLGHGDLFERVLEKDFKATAFVRAKQEGVFSGEKYALELLEMTGIECVQTIKDKERFKPKDALMEIRGDFSMLLKVERTLLNLLQHSSGIATLTSRFVEALNSHKVRLLDTRKTRPLLRIFEKYSVLNGGASNHRLGLDDALMLKDTHLRHVKDLKSFLTHARKNLPFTAKIEIECESFEEAKNAMNAGADIVMCDNLSVLETKEIAAYRDAHYPFVLLEASGNISLESINAYAKSGVDAISVGALIHQATFIDMHMKMA
What is the function of this protein?
Involved in the catabolism of quinolinic acid (QA).
What are the official names of this protein?
Probable nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NadC/ModD family.
Protein: RL30_CLOAB
Sequence: MAKISITLKKSLIGRKKDHIATVNALGLKKIGRTVEHEDTPQIRGMIKKVDYLLEVK
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RPOB_LACPL
Sequence: MAGHLVKYGKHRTRRSYARIKEVLDLPNLIEIQTDSYQWFLDEGLREMFEDIMPIDDFAGKLSLEFVDYQLLEPKYTVEEAREHDANYSAPLHVTLRLTNHETGEIKSQDVFFGDFPLMTEQGTFIINGAERVIVSQLVRSPGVYFNEELDKNGRPSYGTTVIPNRGAWLELETDAKNVSYVRIDRTRKIPLTELVRALGYGSDDDIIDMLGETDSLMLTLEKDVHKNTDDSRVEESLKDIYERLRPGEPKTADSSRSLLTARFFDPKRYDFAPVGRYKVNKKLSMKTRLMDQTLAETLADPDTGEVIAQKDTVIDKNVMAKLSPYLERDDFKTVTYTPSDEAVVTNPMVLQVVKVYSQNDPEKVVNVIGNGNIDLKFKHIVPADIIASINYFFNLQEGLGSTDDIDHLGNRRIRSVGELLQNQFRIGLSRMERVVRERMSIQDAATVTPQQLINIRPVVASIKEFFGSSQLSQFMDQTNPLGELTHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINSLSSYAKVNRSGFIETPYRRVDWTTHKVTDKIDYLAADEEDQFVIAQANSPLNDDGSFVEDTVLARNKEENLETPIENVDYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLLDPHAPLIGTGIEYKAAHDSGIALICRHEGTVEYVDAREVRVRRDDGSLDTYKLMKFRRSNGGKNYNQRPIVKVGDHVDNDEVLADGPAMEGGELALGQNPLVAFMTWNGYNFEDAIIINERLVREDVYTSIHIEEYESEARDTKLGPEEMTREIPNVGEDALKNLDEDGIIRIGAEVKDGDILVGKVTPKGVTELSAEERLLHAIFGEKAREVRDTSLRVPHGGGGIIQDVKIFTRENGDELSPGVNMMVRVYIAQKRKIQVGDKMAGRHGNKGTVSIVVPEEDMPYMPDGTPIDIMLSPMGVPSRMNIGQVLELHLGMAARKLGIHMATPVFDGAQDTDIWEAIREAGVDSDAKSIVYDGRTGEPFDKRVAVGVMHYMKLSHMVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDVVGRVKTYEAIVKGEPIPKPGVPESFRVLVKELQALGLDMKVLDSEDKEIELRDMDDDDDEVVNVDALSKFKQQQDEKAADKAAKADAAKPSETTNAQQDNQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: Y370_STAAN
Sequence: MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLLGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKVLAESTNKVEKNAVTEDKADSKDSKVAGVNTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNENAAETSNKEATVDADAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
What are the official names of this protein?
Uncharacterized protein SA0370.
Protein: RS7_DROYA
Sequence: MAIGSKIIKPGGSDPDDFEKSIAQALVELEANSDLKPYLRDLHITRAREIEFGSKKAVIIYVPIPQQKVFQKIQIILVRELEKKFSGKHVVVIGERKILPKPTRKARNPLKQKRPRSRTLTAVYDAILEDLVFPAEIVGKRIRVKLDGSQLVKVHLDKNQQTTIEHKVDTFTSVYKKLTGRDVTFEFPDNYLNV
What are the official names of this protein?
40S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS7 family.
Protein: PXPA_STAAS
Sequence: MRVDLNCDLGEAFGNYSFGGDHQIIPLITSANVACGFHAGDENVMNETVKLAKAHNVAVGAHPGLPDLKGFGRRNIDISNDEIYNLMIYQLGALQGFCRIHQVKINHVKPHGALYQMGAKDREIASVIAQAVYDFDPSLVLVGLANSYLISEAKNVGLITASEVFADRRYEDDGQLVSRKESDAVITDTDEALKQVLKMVKENKVISKNNKEVTLQADTICVHGDGEHALLFVSKIREILMKEGIDIQSL
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: FDHD_YERP3
Sequence: MSQIKPSRLSSSAEIRGARQLDVLQRHKLAEPQQDWLAEEVPVALVYNGISHVVMMATPKDLAAFALGFSLSEGIISSPQEIYAIEITPGCNGIEVNIELSSRRFAGLKERRRAMAGRTGCGVCGIEQLDDIFRPITPLPFTQAFNLEHLDTALAQLKQVQPVGQLTGCTHAAAWINPEGELLGGCEDVGRHVALDKLLGIRAKQPWQQGAVLVSSRASYEMVQKTAMCGAEILFAVSAATTLAVEVAERCNLTLVGFSKPGRATVYTHPQRIK
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1M_VARDU
Sequence: MPLTMTITNSLMYIIPILIAVAFLTLMERKMLGYMQLRKGPNITGPYGLLQPIADGLKLFTKEPIRPLNTSPILLILSPMLALTTALLIWTPIPMPHALTNLNLGLLSTLAISSMAVNSTLWAGWAPNSKYALIGSLRAVAQTISYEVTLGIILLSTLMLTGGFTMQLLTTTQKHTWLLTTSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFLAEYTNIISMNLLTCILFINPGPTQHPELFLTNLIIKTMILSMSFLWIRASYPRFRYDQLMHLLWKQFLPLTMALCLLHTSLSISISGIPPLS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TILS_RHOJR
Sequence: MVLPEEPAILEVRHAVRRWIAAHAPDGEIAVALSGGADSLALTAAAAAEARSVCALVVDHRLQPGSADVADEAAARARALGCASAEVLPVDVTGSGGLEAAARQARYRALDSARGTRPVLLGHTLDDQAETVLLGLSRGSGGRSIWGMSAYDTPWGRPLLDVRRALTRQACAELGLSPHEDPHNASPDFVRVRLRTEVLPLLEDVLGGGVAGALARTGEHLREEGAVLDAMAADAQAKAVVEGEIDTALLALSAPPVRRRVLRSWLLAAGARGLGDTQLRAVDDLVARWRGQGQVAIGGGTPDARFVVRRRRGRLNVGLDDRRRV
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGR4_RAT
Sequence: MPGPLRLLCFFALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKSFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLRTVPSEAIHGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGLDNLETLDLNYNNLDEFPQAIKALPSLKELGFHSNSISVIPDGAFGGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLTGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLSYNNIRDLPSFNGCRALEEISLQRNQISLIKENTFQGLTSLRILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKDALAARDFANLRSLSVPYAYQCCAFWGCDSYANLNTEDNSPQEHSVTKEKGATDAANVTSTAENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALLFNLLVILTVFASCSSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVFAKDLMKHGKSSHLRQFQVAALLALLGAAVAGCFPLFHGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSENSQSSVIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTRKHGSVSVSISSQGGCGEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPVLTAASCQRPEAYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLQRVRD
What is the function of this protein?
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs.  Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal.  Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.  May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo.  Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells.  Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts.  Acts as a regulator of bone formation and remodeling.  Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state.  Involved in the development of the anterior segment of the eye.  Required during erythropoiesis.  Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production.  Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP.  Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity).
What are the official names of this protein?
Leucine-rich repeat-containing G-protein coupled receptor 4, G-protein coupled receptor 48.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS4_STAAR
Sequence: MARFRGSNWKKSRRLGISLSGTGKELEKRPYAPGQHGPNQRKKLSEYGLQLREKQKLRYLYGMTERQFRNTFDIAGKKFGVHGENFMILLASRLDAVVYSLGLARTRRQARQLVNHGHILVDGKRVDIPSYSVKPSQTISVREKSQKLNVIVESVEINNFVPEYLNFDADSLTGTFVRLPERSELPAEINEQLIVEYYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: KGUA_BACHK
Sequence: MRSRRGLLIVLSGPSGVGKGTVRKELFSHEDTRFQYSISVTTRKPREGEVDGVDYFFKEREEFEEMIRNEKLLEWAEFVGNYYGTPIDYVEKTLQEGKDVFLEIEVQGAIQVKKAFPEGVFIFLAPPSLSELKNRIVGRGTETEDVIENRLTVAKEEIDMMDAYDYVVENDQVELACERIKAIVVGEHCRRERVAKYYKEMTEGL
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_CAMJD
Sequence: MQENLLEKQFLNHPLYAKIQELKALNLACNFSLDDSVNLSTNSQAKDEILTITKKLKPWRKGPFKIDDLFIDTEWQSFIKFNILKPFMGEISQKCVADIGCNNGYYMFKMLEFNPAKLIGFDPSIKYRLQFELINALAKTPIKYELLGVEDLPNYGLKFDVIFCLGVIYHRSDPIKMLKDLKAGLNKNGVVFLDTMYIEDEREIALVPNKTYSKIPNIYFVPSISALKNWCERAGFKEFEVLATKKTDENEQRKTEWIDSFSLENFLDPKDKNLTIEGYEAPKRVYIRIKI
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: SOPB_SALTI
Sequence: MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWGNYLQHQKTSNHSLHNLYNLQRDLLTVAATVLGKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIELIAARTQQQNGLPAKEAHRFAAVAFRDAQVKQLNNQPWQTIKNTLTHNGHHYTNTQLPAAEMKIGAKDIFPSAYEGKGVCSWDTKNIHHANNLWMSTVSVHEDGKDKTLFCGIRHGVLSPYHEKDPLLRQAGAENKAKEVLAAALFSKPELLNRALEGEAVSLKLVSVGLLTASNIFGKEGTMVEDQMRAWQSLTQPGKMIHLKIRNKDGDLQTVKIKPDVAAFNVGVNELALKLGFGLKASDSYNAEALHQLLGNDLRPEARPGGWVGEWLAQYPDNYEVVNTLARQIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKRELISFHQTHMLSAPGSLPDSGGQKIFQKVLLNSGNLEIQKQNTGGAGNKVMKNLSPEVLNLSYQKRVGDENIWQSVKGISSLITS
What is the function of this protein?
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2.  It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC).  Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements.  The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell (By similarity).
What are the official names of this protein?
Inositol phosphate phosphatase SopB, Effector protein SopB.
What is the protein family that this protein belongs to?
Belongs to the phosphatase IpgD/SopB family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS).
Protein: LDH2_STAAR
Sequence: MKTFGKKVVLIGDGSVGSSYAFAMVTQGVADEFVIIDIAKDKVKADVQDLNHGTVHSPSPVDVKAGEYEDCKDADLVVITAGAPQKPGETRLQLVEKNTKIMKSIVKSVMDSGFDGYFLIAANPVDILTRFVKEYTGLPAERVIGSGTVLDSARLQYLISQELGVAPSSVDASIIGEHGDTELAVWSQANVAGISVYDTLKEQTGSEAKAEEIYVNTRDAAYEIIQAKGSTYYGIALALMRISKAILNNENNVLNVSIQLDGQYGGHKGVYLGVPTLVNQHGAVKIYEMPLSAEEQALFDKSVKTLEDTFDSIKYLLED
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate (Potential).  Contributes to S. aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells, despite playing a secondary role in this resistance mechanism (By similarity).
What are the official names of this protein?
L-lactate dehydrogenase 2, L-LDH 2.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.