PharMolix/UniProtQA huggingface dataset:
Protein: SYGB_SINFN
Sequence: MPDLLIELRSEEIPARMQRKAAGDLKKLVTDALVEAGLTYEGAREYWTPRRLTLDIRGLNARSADVREERKGPRTDANEKAIEGFLRAAGLSSIGDAHVHSDPKKGDFYVAHIVKPGRDAEDIVAEVMPAIIRDFPWPKSMRSGAASAKPGSLRWVRPLQSIVCTFGAETEETRVIPFAVDGITASNITYGHRFHAPEAIMVRRFADYADKLEKAKVVLDAERRKEIIGADARNIAFANGLELVEDEGLLEEVTGLVEWPRVLMGSFEESYLEIPSEIIRLTIKTNQKCFVTRQPGAETLSNRFILVSNIEAKDGGKEIVHGNGKVVRARLSDAAHFWKRDQGDLPDLETLKPSAEKFGLDLGKPLDQRMAKLDALNVTFHAKLGTQGERVARIRSIALALAEVTGADQALVERSVVLAKADLRTEAVGEFPELQGIMGHKYAVLQGEDAAVANAIEDHYKPQGPSDRVPTDAVSAAVALADKLDTLAGFWAIDEKPTGSKDPYALRRAALGVIRLILEGRTRLPLLPFFDVALKALRTQRPDLTGDIAADLLAFFHDRLKVYLRDLGARYDLIDAVLTSEADDLLMIARRVEALTAFITAEEGKNLLAGTKRATQILAAEEKKGTEVADQVDERLFRLDAERTLHASIKLASDDAREAIGKEDFRSAMAALSKLREPVDVFFNDVLVNDEDRAIRANRLALLGLIRSATGEVADFSKISG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPP_ECOK1
Sequence: MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDVYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQNELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: DUT_CERS4
Sequence: MRPVVRVIREDWADTALPLPGYETAGAAGADLRANLPPESRAEGLVLAPLGRVLVPTGLRIEIPDGFEVQIRPRSGLALKHGISLPNSPGTIDSDYRGPLGVILVNLGDEPFRVAHGDRIAQMVVAPVVQARFELADGLGATARGAGGFGSTGTA
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ARGR_STRPN
Sequence: MRKRDRHQLIKKMITEEKLSTQKEIQDRLEAHNVCVTQTTLSRDLREIGLTKVKKNDMVYYVLVNETEKIDLVEFLSHHLEGVARAEFTLVLHTKLGEASVLANIVDVNKDEWILGTVAGANTLLVICRDQHVAKLMEDRLLDLMKDK
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBF_PINTH
Sequence: MTIDRTYPIFTVRWLAVHGLAIPTVFFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DDX51_DICDI
Sequence: MTTINYNENINNNNNTLESFGIEEWLINNLKEQSIINLFPVQQEIVPFINRTEGHDICVCAPTGSGKTLAYAIPLVQKIVKRVVRRVRVAVIVPTHDLVIQVEKTFQSIIKGTDLVVLSLGVKPFHIEQKLLIKNHSYGEHALYESLVDIIVSTPGRIVDHINETLGFTLKYLNYLVIDEADRLLRQSFQDWLEIVIDSTNQHSDLNQQQEEQLIKYNSKGDIELFEKSISLKDNNNQMNHLCWSEFKLVKLLLSATMTYNPSKISLLQLNAPLFFTTSKTKEIKYSMPSTLKECYIISNGDQKPLVLLNIIYESLLKNNANGENKKKIICFTKSVDITHRLNTLLKLIGQVDKLKFTCEEYSSSLSTVERADLLSRFKLNQIDILICSDIMSRGMDIQDIDVVINYNTPPNITLYVHRVGRTARAGNFGVSYTIVDKSEIKYYISMMKKAERSQTLHCLKWKPNVYEKFQSSYKLGLNQMRLIYSKRKINDIGDNGDDNNDNNNEDGNEIDGSVENIENNNNNNNNNNKNNNNNNFEKDYEVKLKHSLLEISKKKAKINFNI
What is the function of this protein?
Probable ATP-binding RNA helicase which may be involved in ribosome biogenesis.
What are the official names of this protein?
Probable ATP-dependent RNA helicase ddx51, DEAD box protein 51.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: UVRB_YERP3
Sequence: MSKSFKLHSVFKPAGDQPEAIRKLEEGLENGLAHQTLLGVTGSGKTFTVANVIADLNRPTMILAPNKTLAAQLYGEMKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTRGMIIDQRSILRRLSELQYSRNDQVFQRGTFRVRGEVIDIFPAESDEWALRVELFDEEVERLSIFDPLTGQLQHEVPRFTVYPKTHYVTPRERILQAMEEIKVELAERRQVLLANNKLLEEQRLSQRTQFDLEMMNELGYCSGIENYSRYLSGRGPGEAPPTLFDYLPADGLLIVDESHVTIPQIGGMYKGDRSRKETLVEYGFRLPSALDNRPMRFEEFEALAPQTIYVSATPGKYELEKSGGDIIEQVVRPTGLLDPLIEVRPVATQVDDLLSEIRIRAAINERVLVTTLTKRMAEDLTDYLSEHGAKVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDRITASMEKAIGETERRRAKQQAYNEERGIIPQGLNKKIGDILQLGQPSMRGKGKGRGSHKMADTTQYQSLSPKALDQKIRELEAKMYTYAQNLEFEQAAELRDQVHQLRQQFIAIS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_BACC1
Sequence: MKLNRAIGVIDSGVGGLTVAKELIRQLPKERIIYLGDTARCPYGPRSREEVRQFTWEMTEHLLDLNIKMLVIACNTATAVVLEEMQKQLPIPVVGVIHPGSRTALKMTNTYHVGIIGTIGTVKSGAYEEALKSINNRVMVESLACPPFVELVESGNFESEMAYEVVRETLQPLKNTDIDTLILGCTHYPILGPVIKQVMGDKVQLISSGDETAREVSTILYHSKMLNEGEEQSDHLFLTTGKIGLFKEIASKWFGQPIENVKHIYLEKE
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: PYRB_STUS1
Sequence: MTPTDAKRPLQLNDQGQLRHFLSLDGLPRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFELAAKRLSADVITLNVSTSSTSKGETLTDTLRNLEAMAADMFVVRHADSGAAHFIAEHVSPDVAVINGGDGRHAHPTQGMLDMLTIRRHKGSFDNLSVAIVGDILHSRVARSNMLALRTLGCPDIRVIAPKTLLPEGIEQYGVRVFTDMNEGLRDVDVVIMLRLQRERMQGGLLPSEGEFYKLYGLTTQRLALARPDAIVMHPGPINRGVEIESAVADGPQSVILNQVTYGIAIRMAVLSMAMSGQTAQRQIDSESVSEEQQ
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL24_PHYMT
Sequence: MHIKLGDKVAIIAGKNRFVTDENGKKIIKTGKILKIFHKQQKVLVEGINIVFKHKAPLKDEDKGNIIKQEAPIHISNVALIDSLKNVPTRVGYRIENNKKVRYFKKSGTIIEDLN
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: A1AG1_HUMAN
Sequence: MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES
What is the function of this protein?
Functions as transport protein in the blood stream.  Binds various ligands in the interior of its beta-barrel domain.  Also binds synthetic drugs and influences their distribution and availability in the body.  Appears to function in modulating the activity of the immune system during the acute-phase reaction.
What are the official names of this protein?
Alpha-1-acid glycoprotein 1, AGP 1, Orosomucoid-1, OMD 1.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS3_STRCO
Sequence: MGQKVNPHGFRLGITTDFKSRWYADKLYKDYVKEDVAIRRMLTSGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADKIRGQLEKLTGKQVQLNILEVKSPETDAQLVAQAVAEQLSSRVSFRRAMRKSMQGTMKAGAKGIKIQCGGRLGGAEMSRSEFYREGRVPLHTLRANVDYGFFEAKTTFGRIGVKVWIYKGDVKNIAEVRAENAAARAGNRPARGGGNDRPARGGRGGERRGRKPQQQSAPAAEAPKAEAPAAAAPAESTGTEA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: TOP1_USTMA
Sequence: MNSIQVKNEPMLASFASTSTNGKAKRSAKPSLFSGSEVSSDDDEEKPLAKRPKVEDSDSDAPLTSTVSSQNGVQKRSGSSNNDDNDDDSDSDSDAPLTALVKKSNGSDDDEDDDDDDDEGDDDDEEDDDDDDDDDDKPLSKSSKSNRKPPKTMSITGSGEKKWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHPKAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFLDATSNFKTNSDREKFEKARKLDTVVKQIRRDVNKNLKSKVRHERQIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCEHAQIKMPDTIHLEFLGKDSMKFEEDLKITNPDVFKNIAMFLKSNGMKDKSGNYVRKKPSDPIFCAPESGSGKMQPLQPNSVNQFLSKYMKGLSAKVFRTYNASVTFQGLLEQTEEWLKSRPNAAEREINQTNLRLAYNEANRQVAILCNHQKTVNPMLLNRNLERTQDKIFQIRYEIMKEQQKILTFHKVSELKKEFKVKEHPFMKQFDKIMQKQDLDAEKVKQYEEQMISDKKSKLESTFKRQQSELQYQLEQKGLTGDDGTPKKGKKAKNVEEEVRSSIKGFKDKKQVDEELKALNETAKRLEKERKTNKSQATSCNFVSSAKKILSKYEMIKKQEAELVNKNNTSDVALSTSKLNYIDPRITLAWLKEWDDRLSDLGQGKAAPKKKVKKEEEENDIKPKKKDAKGAASKKRAAKTGLANSTGDSEKMELGLQVMNISQFFANALQKKFKWAASGDDGRDISAKWVFVKDAQSKMRKLDSAERKGQKGGSMAAMTDAADSKEAQPKVNCVLKKQTSADRKMSKPIKAVDKTEESDDDLSSDSSDDEDKPLAAVV
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.
Protein: MUTH_HAEI8
Sequence: MIPQTLEQLLSQAQSIAGLTFGELADELHIPVPIDLKRDKGWVGMLLERALGATAGSKAEQDFSHLGVELKTLPINAEGYPLETTFVSLAPLVQNSGIKWENSHVRHKLSCVLWIPIEGSRHIPLRERHIGAPIFWKPTAEQERQLKQDWEELMDLIVLGKLEQITARIGEVMQLRPKGANSRAVTKGIGKNGEIIDTLPLGFYLRKEFTAQILKAFLDVKPL
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_ACIAD
Sequence: MLDVGFGELFCFGIIALLVLGPDKLPVAARFAGRWYARIKRYISNIQNEIDRELNLSEFRKEMQDELDRLHTLEQTMQARLKEIEKASTEKIAEQPKQPIESEPSITPQKYIFCITPQTIVPFCHQKQHYQQPERYNDLVLESSSVELKIAV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LCL3_ASPOR
Sequence: MRWPPWASESQARDKQDEQNQKNWDKSLNAIDWAAFTEPRTLIPTLILTTGIIGALQIHRRYLRRFPDAVSISPSYFRKRTILGQVTSVGDGDGFRLYHTPGGRLAGWGWLPWKRVPTAKKDLRDKTISVRLAGVDAPELAHFGRPEQPYAREAHEWLTSYVLNRRVRVLVHRQDQYQRVVASAYVRRAIDFPIPFRRRDVSYEMLTRGLATVYEAKAGSEFGGPELERKYREAESIAKRKGTGLWKGYRRNRKGWESPREYKTRMGLEEQSQGKGN
What are the official names of this protein?
Probable endonuclease lcl3.
What is the protein family that this protein belongs to?
Belongs to the LCL3 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single- pass membrane protein.
Protein: ARGB_ACTP2
Sequence: MLQNEVENFANLLEQATVYLAPYQEKIIVVKYGGNAMINEDRKKLVMQDILLLNQLGVKVVLVHGGGPEISQGVKLLGKEPQFINGLRVTDQDTINVVLQMLAGKVNKSLVALLKGKGVGLCGIDANMLQCEKLQAEVDYGFVGEIVKVNTQLLELALSANLIPVISTVGVDDQGVAYNINADTVASEIAMALGAAKLVSMTDIAGLLRDRFDESTLIPEVEVSEVQGLIDQGIIAGGMIPKIACCTDFINAGGIEANIIDGRVPHAILVSLFGGKNGTLFYKK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCP4_NEUCR
Sequence: MPPKRRQAEDTSDAEPQYTKKSKGNTGKAQPQELTKGSDQDGNTFWELGNNRRISSSVFRNTTLVNIREYYDAGGKLMPGKKGISLSLAQYQNLLKVIPQLNADLRAQGHAIEDPGFAQVAEQTDAPIETPKVKALESNKESIKKEKKKPRKSNIDVTSDEEEAAEDEDDDE
What is the function of this protein?
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery.  Binds single-stranded DNA (By similarity).
What are the official names of this protein?
Putative RNA polymerase II transcriptional coactivator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional coactivator PC4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TLCD1_CHICK
Sequence: MGPGWRAPSAALVGGSVALFGALRRAALALPRPAAVRSRPGRVWRWRNLLVSFAHSVLAGLWALFSLWQSPELLSDIQDGYSVSGHLLVCFSSGYFIHDSLDIIFNQQSRSSWEYLVHHAMAISAFVSLIITGRFLVAAMLLLLVEVSNIFLTIRMLLKMSNVPSPALYEANKYVNLVMYFAFRLAPQVYLTWYFVRYVEVQGQGAFLMANLLLLDAMILMYFSRLLRSDFFPSLRKGSVGRDVDGEKFLID
What is the function of this protein?
Regulates the composition and fluidity of the plasma membrane (By similarity).  Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity).  Does not appear to have any effect on LCPUFA synthesis (By similarity).
What are the official names of this protein?
TLC domain-containing protein 1, Calfacilitin.
Protein: TOP1_STAAC
Sequence: MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDCPKCNQYLVENKKGKTTQVICSNCDYKEAAQK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: ISPG_ACTPJ
Sequence: MSIHQSPIKRRESKKIWVGNVAVGGDAPISVQSMTNTRTTDVEATVAQIKSLERVGADIVRVSVPTMDAAEAFKVIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRAVVDCAKDKNIPIRIGVNAGSLERDLQEKYGEPTPQALLESALRHVDILDRFNFENFKVSVKASDVFLAVESYRLLAKQIVQPLHLGITEAGGARAGSVKSAVGLGLLLSEGIGDTLRISLAADPVEEVKVGFDILKSLRIRSRGINFIACPTCSRQEIDVIATVNALEQRLEDILTPMDVSIIGCVVNGPGEALISDLGVTGSNKMSGFYLDGVRQKERFDNEKLIDQLEAKIRARVAEQHNRIQIEQI
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RL13A_BOVIN
Sequence: MAEGQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALERLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQAEKNIEKKIGKFTEVLKTHGFLV
What is the function of this protein?
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions.  Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.  Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.  In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex.  Involved in methylation of rRNA.
What are the official names of this protein?
60S ribosomal protein L13a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLVH_ASPFN
Sequence: MSEFIPTWKQPSHPETLQVIKGATPYTASARSLVALPAGALFSKITTAIPAPKKTYTSVQTGPGLNIELMSDLVYCNHSCSPSLEFDMSTFEVRVSRDRPLSVGDELTFFYPSTEWDMVQPFNCFCGSQNCLGLIAGSQDMEASVLSRYWLNPHVKDLLAGKQMTVAPESTEEISLKA
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of flavunoidine, an alkaloidal terpenoid with a tetracyclic cage-like core connected to dimethylcadaverine via a C-N bond and acylated with 5,5-dimethyl-L-pipecolate (PubMed:31885262).  The tetracyclic core is synthesized by the terpene cyclase flvE and the cytochrome P450 monooxygenase flvD (PubMed:31885262).  The terpene cyclase flvE catalyzes the cyclization of farnesyl pyrophosphate (FPP) to form (1R,4R,5S)-(+)-acoradiene and the cytochrome P450 monooxygenase flvD is then responsible for oxidative conversion of (1R,4R,5S)-(+)-acoradiene into the tetracyclic cage present in the final product flavunoidine (PubMed:31885262).  In parallel, the N-methyltransferase flvH dimethylates L-lysine to give N,N-dimethyl-L-Lysin which is decarboxylated by flvG to afford dimethylcadaverine (PubMed:31885262).  The terpene cyclase-like protein flvF is the enzyme that attaches the dimethylcadaverine precusor at the C-7 of the tetracyclic cage to yield pre-flavunoidine (PubMed:31885262).  The cytochrome monooxygenase flvC hydroxylates the C-10 position of pre-flavunoidine whereas the NRPS flvI acylates the terpenoid core at the hydroxylated C-10 with dimethylpipecolate to yield final flavunoidine (PubMed:31885262).  The bifunctional enzyme flvA and the dehydrogenase flvB are responsible for the synthesis of the dimethylpipecolate precursor (PubMed:31885262).  The PLP-dependent lyase domain of flvA might use L-O-acetyl-homoserine and alpha-keto-isovalerate to form an intermediary ketone that can cyclize intramolecularly to yield an imine (PubMed:31885262).  The imine can be reduced by flvB to yield the 6-carboxylated pipecolate (PubMed:31885262).  The C-terminal alpha-KG-dependent oxygenase domain of flvA is then proposed to catalyze the decarboxylation to yield dimethylpipecolate (PubMed:31885262).
What are the official names of this protein?
Methyltransferase flvH, Flavunoidine biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Protein: GLGB_BURP0
Sequence: MTDAPFDRADIDALLDARHPDPFACLGPHRVGDATVVRTLLPGALRVRAIAAGGGVLGELRQVDPAGCFAGALPDGRERGERPRYRLSIDWPDARQDVEDAYAFGTLLDEDALARFAAGDPRAALACLGARALDMDGVPGVRFAVWAPGASRVSVVGDFNGWDARRHPMRLRRPWGVWELFVPRIGAGERYKFALRARDGAALPLKADPCACRTEAPPRTASIVADLDALERFGWHDDAWLRARASLDLAHAPVSIYEVHPESWLRVAAEGNRSATWDELAQRLIPYAAGMGFSHVELTPIAEYPFGGSWGYQSLSPFAPSARFGPPEGFARFVEHAHAAGLGVIVDWVPAHFPDDPHGLGKFDGTALFEHADPREGWHPDWHTHVFNVGRREVGAFLIASALAWAHRYHVDGIRVDAVASMLYRDYSRAAGEWVPNVYGGRENLESIAFLKHFNDTLHGPAAPPGVATFAEESTAWPGVTAPTAEHGLGFDFKWNMGWMHDTLAYLREDPIHRRHHHDRLTFGLVYAFSERFVLPLSHDEVVHGKGSLAAKMPGDAWQRLANLRAYFGFMWAHPGKKLLFMGGEFAQWGEFAHDATPQWDLLDAPAHRGVQRLVRDLNRLHAAEPALHALDDRPAGFAWLVGDDRNNSVFAFVRRDDAGRMLVAVCNFTPVPRTDYRLGLPAPGRWAEVLNTDGAAYGGTDAGNGGALQADEIPAHGERWSAALRLPPLATLWLRPA
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.