PharMolix/UniProtQA huggingface dataset:
Protein: GMHA_ALTMD
Sequence: MIEQIKANFTESIQTKIAASEILPEHIEKAAYMIVEALIRGNKVLSCGNGGSAGDAQHFASNMLNRYERDRPSLPAIALSTDTSTITSIANDYSYDEIFAKQVRALGQPGDILLAISTSGNSRNVIAAMEAALSRDMTIVALTGKDGGEMAGFLSEHDVEIRVPSNRTARIQEVHLLVIHNLCECIDDSLFPADHGDE
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_RICCN
Sequence: MINISFPDGSIKQFAKNITAYEVANAISMSLAKAAMVAEINGELQDLSIVIDNDCKLRILTAQDPECLEIIRHDAAHLTAEAVKELFPETQVTIGPAIENGYYYDFARDKPFTTDDLAVIEAKMQELSQKNEQVTRELWDRDKAVEFFKSIGEHYKAEIIASIPAGEPITLYRQGNFIDLCRGPHAPSTGVVKHFKLMKVAGAYWRGDSRNEMLQRIYGTAWATKEQLDSYLLMLEEAEKRDHRKLGRELDLFHFQEEAQGMVFWHDKGWSIYNTIEQYIRKKIRKNGYTEVKTPVLVDKSLWEASGHWEKFRDDMFALETDDKTLALKPMNCPCHVQIFKQGIKSYRDLPLRMSEFGLCHRNEASGALHGLMRVRSLVQDDAHIFCAAEQITDETVSFCKLLTEVYKDFGFTDIKVKFSDRPEIRAGSNEVWDKAENALKEAVEQAGFNYTLNPGEGAFYGPKLEFVLTDAIGRQWQCGTLQMDFVLPERLDASYVAASGEKKRPVMLHRAILGSLERFIGILIEEYAGRFPLWLAPVQVAIATITSDLNDYALEVQKALIDNGVRTDFNISPDKINYKIREFSNQKIPMIAVIGKQEQENKQVAIRRLGTTDQEVLSVEQLIAVVKEENEKYL
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_AQUPY
Sequence: MPRLKTRREKRLRRHKRIRKKVFGTPERPRLCVYRSLNHFYAQIIDDTIGHTLVSASTLDPEFEKITGKRGGKSIKDAEVVAEIIARRALEKGIKKVVFDRGGFKYHGKIKAFADKCREMGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RPOB_LACJO
Sequence: MLGHAVNYGSHRTRRSFSRIKEVLKLPNLTDVQTQSYKWFLNEGIREMFDDIMPISDFSGKLSLEFVDYKLLKPKYTLEEARDHDANYSAPLHVTLKLTNHETGEIKTQDVFFGEFPLMTDSGTFVINGAERVIVSQLVRSPGVYYHSDFDKNGRQIFGATVIPNRGAWLEYETDAKDLAYVRIDRTRKLPLTVLIRALGFGSDSEIADMFGESDSIRFTLEKDIHKNPADSRVAEALKDIYERLRPGEPKTTDSSRSLLYARFFDPRRYDLAPVGRYKINKKLSLKNRLLRQTLAETLADPDTGEIIAKKGDVVTHELLDKLSPYLDRDDFKMVTYEPSKEGVLPDPVTVQEIKVYSKVDPERVVKLMSNGHIADDVKHLTPADVLASINYFFDLQDNIGTTDDIDHLGNRRIRRVGELLQNQFRIGLARMERVVRERMSIQDISTVTPQQLINIRPVVASVKEFFGSSQLSQFMDQNNPLGELTHKRRMSALGPGGLSRDRAGYEVRDVHYTHYGRLCPIETPEGPNIGLINSLATYAIVNKYGFIETPYRRVSWDTHKVTDKIDYLTADVEDNYIIAGANARLNEDGSFKDKIVLARHKEDNLEVTPDKIDYMDVIPKQVVSVTSACIPFLENDDSNRALMGANHQRQAVPLINPHAPIVGTGMEYRAAHDSGDALVAKAPGVVEYVDANEIRIRRDDDTLDKYVLEKFRRSNATKNYNQTPAVKQGERVVADEVIADGPAMENGELALGQNPIIAFLTWNMYNYEDAVMISERMVKDDVYTSIHIEDYESEARDTKLGPEEITREIPNVGEDALKDLDEEGIVRIGAEVQDGDILVGKVTPKGVTELSAEERLLHAIFGEKAREVRDTSLRVPHGGGGIVQNVQVFTREAGDELPPGVNKMVRVYIVQKRKIQVGDKMSGRHGNKGTIALVCPEEDMPYLPDGRPVDICLNPMGVPSRMNIGQVLELHLGIAAKQLGIHVATPVFDGASEDDMWNMVREAGIGKDGKTVLYDGRTGEPFHNRVSVGIMYYLKLTHMVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTYKSDDVVGRVKAYEAIVKGERIPKPGVPESFRVLVKELQSLGLDIKVLDMDHKEIELRDMDDDSNDHFNIDTLSKLAEQQEKKKLAEEAAKKDDKPDEPVDESDSSTSSDDKVSK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: NUSB_NEIM0
Sequence: MKTARRRSRELAVQAVYQSLINRTAAPEIAKNIREMPDFAKADEELFNKLFFGTQTNAADYIQKIRPLLDRDEKDLNPIERAVLLTACHELSAMPETPYPVIINEAIEVTKTFGGTDGHKFVNGILDKLAAQIRPDEPKRR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: TNPA_STAAU
Sequence: MKVQRIEVENKPYPLYLLLDKEYQLIEPVMKFIKYLDNTGKSPNTIKAYCYHLKLLYEFMEQRGVILNDINFELLADFVGWLRYPSASNVIDLQSKKAIREETTVNTILNVVMSFLDYLSRLGEFKSIDVFKQAKGRNFKGFLHHVNKGRYQKNVLKLRVKKKQIRTLRSKEVKQIIDACHTKRDKLILMLMYEGGLRIGEVLSLRLEDIVTWDNQIHLTPRDVNVNEAYIKLRKERTIHVSKELMSLYTDYLIYEYSEELEHDYVFISLKEGYFGKPLKYQSVLDLVRRIVKRTGIEFTSHMLRHTHATQLIREGWDVAFVQKRLGHAHVQTTLNTYVHLSDQDMKNEFNKYLERKEHKK
What is the function of this protein?
One of three proteins encoded by transposon Tn554 required for its transposition.
What are the official names of this protein?
Transposase A from transposon Tn554.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: H3C_HUMAN
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFNTDLRFQSAAVGALQEASEAYLVGLLEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  Hominid-specific H3. 5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
What are the official names of this protein?
Histone H3.3C, Histone H3.5.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MIAA_HERA2
Sequence: MQAPQPLIIAIVGPTAVGKTAFSLDLAQALNGEIVSVDSRLVYRGMDIGTAKPTPAEQALVKHHLIDVVNPDQEYSLATYQAAAYAAIAQIQQQAKQPILVGGTGQYMAALLEGWSIPEVAPNYELRARYEQQAASEGHAALHQQLQTIDPEAAKAIDPTNVRRVIRALEVFHETGQPISQLQQRNPPHYRILTLDLERPRDELYARIDQRVDLMMREGLIAEVWALIRQGYGWELPSMSGLGYAEFRPLWQGQQSAGACISQLKFNTHRFARKQGAWFRRLPKRVSLDARHTDLLAQVQELLAMPEHAPIHTDH
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RPOD_TREPA
Sequence: MMELSRTPAVMRLLEYAREKKAITHDEVENILAHYGVETEELLHDVLDMLEQENIKVFSSEEEELEDEVFAGLKGPAADDGDGSFPLSTERVRDKLCDSSRGARQNLLSNARNIALDDPVKLYLRDIGQEKLLTAEQEVMLSKRMEEGEGIIKDIITQSGLLLPEFYHIGRSLSKKALAVLDPAESGRTRKEISEEMADRRRLKQAYGEVLRSLYPEMRHYMAMKKRLDERGEPVTVLSSDEEVCKQRDKLLSCLQKVDLQLEEIDRFSRKFLDTARKIREYKRRKDRHEKQLMIADLCDMRKIGRGLAVPRQRAKLEETLGMSADCIQEIYTQIQKVTRRLRRIEYDFENTIDGILSMARAIHRGHVMLKKAKDKLINANLRLVVSIAKKYTNRGLLFFDLVQEGNIGLIKAVEKFEYRKGYKFSTYATWWIRQAITRSISDQARTIRVPVHMIEQINKVTRESRQLLQKFGREPSDEEIAQQLCWTVEKVKQVKSVAREPISLETPIGEEEDSSLGDFVPDADVENPSRVTERVLLKEEVRSILSALPAREHEVLRMRFGLDGDYSQTLEEVGLYFDVTRERIRQIEAKALKRLRHPRHSRRLKDFLDS
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor RpoD, Major vegetative sigma factor, Sigma-70.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTF18_DROME
Sequence: MDQYPDENEEFELQYQDELELLEDLPDEFNAYDGPSTSKQAAEKQKENRAPVAALRDSTRLGNSTLGSPQLSQITFGASQLGGEEEAEGTSSGGQVNRRLFGTPKGPPVGRGCSTPFQRMPAIQELENTQLTSRSYGLEKENAAANQLQEVGLKNVNKRRLERDLFGDIDDLFHESYEDPMVKKARTEEQRDHEAIERILELRRKMRESSKTLRKDDVSRLKALHDFKMRNLSYEIPNWPFLAIQRSDLERIYVRFHSEDYEQRQLDLISARGEVVGSLLGEAKDKIWQEAGEIVLSRATAAEDADVTLVNSNANSEPGRLWVDKYKPRKYIDLLSDEMTNRSLLYWLKMWDKVVFGKAFHSKREQEAVTGEGGTAGGAANQLNSFNKRTGKFESNGGWRQRKSRQALNTNVDALGRPMQKVALLCGPPGLGKTTLAHTIARHAGYNVREINASDDRSPEAFKLALENGTQMSSVLNEDKRPNCIVLDEIDGAPRQSIDYLVKFISDAVYTKVKAKGAKAEHNVLKRPIICICNDVYDPALRPLRQVAFVVTFPPIDAARLAERLVKIAFKEQLKTDFGSLIALAEKSGNDVRSCISSMQFFNAQKHSLTLQDVLNNNLGQKDRHQGLFAVWDAIFRIQRPRKTLHTDANKVDEPAQVTMTNTSVTTRVRNVLEVVHSSGDYERLTQGVYENYLQQKMPDPNFTGVCEALKWFCFTDTVQHQISRQQNYSVYPYLQYGFVAWHLLFATLAWPKIAFPTRGFEFQQKSTNQRNIFQALCKGVTTSALGVGQGGTLLLDTVPLLKRILSPQLRSVAVQLLSPKEQQDLRHTIEVMVDLGLTFVQVKSQEGHYVFQTEPDLDALSAFPGYTGLSLPYFSRQLIAREVDLERIRRAAPKGGAPSAPAAKKKTSGAAAQLPNHLQTLKPKPISASNMHSAPKQQLTKDFFGRITHKSTSTNSAEESKTDAIVKSPIWYRYKEGFNNAVRKDVHIHELL
What is the function of this protein?
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission.  Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC).  The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA and has weak ATPase activity.  The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA.
What are the official names of this protein?
Chromosome transmission fidelity protein 18 homolog, CTF18, Cutlet protein.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. CTF18 subfamily.
Protein: RL24_MYCPA
Sequence: MKVRKGDTVLVIAGKDKGAKGKVLKAYPDRERVLVEGVNRIKKHTAISTNQRGAQSGGIVTQEAPIHVSNVMVVDSDGKPARVGYRLDEETGKRVRISKRNGKDI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: DEF2_NITEU
Sequence: MIEPLPRILVSELCKFVMAILNILRYPDERLHKIATEVPSITREIRTLVSNMAETMYAAPGIGLAATQVDVHQRIIVIDVSETRDELLVLINPEIIASSGNAETQEGCLSVPGIFDKVTRAEEVTVRATGIDGKSFEMDASGLLAVCIQHEMDHLMGKVFVEYLSPFKQSRILSKLKKQARRQIA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 2, PDF 2, Polypeptide deformylase 2.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RS11_LACP3
Sequence: MAGRKTTRKRRVRKNVESGVAHIHSTFNNTLVMITDPRGNAIAWSSAGALGFKGSRKSTPFAAQMAAEAAAKESMEHGMKSVEVAVKGPGSGREAAIRSLQATGLEVTAIRDVTPVPHNGSRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: EFTS_DECAR
Sequence: MAAITAGMVAELRGKTDAPMMECKKALTEADGDMAKAEEILRVKLGNKASKAAVRIAAEGIVAVSISADGKLGSIIEVNSETDFVAKNDEFIALSNGCAALVANQNPADVAALSALPMGEGTVESTRSALVGKIGENMTIRRFVRFEAKGKLVSYIHGGAKVGVVVDLVGGDEQLGKDLAMHIAASKPKSLDSTGVPAELLETERRVAIEKAREAGKPEAMLEKIAEGTVQKYLKDVTLLGQVFVKAADGKQTIEQLLKEKGASVAGFTLYMVGEGIEKKVDDFAAEVAAQAAAAAAKK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUE_ECOLI
Sequence: MQDSILTTVVKDIDGEVTTLEKFAGNVLLIVNVASKCGLTPQYEQLENIQKAWVDRGFMVLGFPCNQFLEQEPGSDEEIKTYCTTTWGVTFPMFSKIEVNGEGRHPLYQKLIAAAPTAVAPEESGFYARMVSKGRAPLYPDDILWNFEKFLVGRDGKVIQRFSPDMTPEDPIVMESIKLALAK
What is the function of this protein?
Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.  In vitro, utilizes preferentially thioredoxin A to decompose hydrogen peroxide as well as cumene-, tert-butyl-, and linoleic acid hydroperoxides, suggesting that it may have one or more organic hydroperoxide as its physiological substrate.
What are the official names of this protein?
Thioredoxin/glutathione peroxidase BtuE.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family. BtuE subfamily.
What are the subcellular locations of this protein?
Periplasm. Note=Appears to have a periplasmic location. It has the mean hydropathy of a soluble protein but lacks an obvious signal sequence.
Protein: SIR5A_XENLA
Sequence: MILLTFHTRRLVSHAYCGLKPASQKKSIALEMTRPSSNLADFREAFAKAKHIAVITGAGVSAESGVPTFRGAGGYWRKWQAQHLATPEAFARNPSRVWEFYHYRREVMLTKNPNPAHLAIAECETRLRKQGRKLVVITQNIDELHRKAGSRNLFDIHGSLFKTRCTSCGRVKENYKSPICPALDGKGAPESDVQDAKIPVEQLPRCEENGCSGLLRPNVVWFGETLDSNLLGEVEKELETCDLCVVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPATTSFTFHFHGPCGTTLPPALARHETELIS
What is the function of this protein?
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins.  Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
What are the official names of this protein?
NAD-dependent protein deacylase sirtuin-5A, mitochondrial, Regulatory protein SIR2 homolog 5-a.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.
Protein: RL2_RHORT
Sequence: MALKQYNPVTPGMRNLVLVDRSDLYKGKPVKKLTEGLVKTGGRNNHGRVTSWWRGGGNKRRYRLIDFKRTKVDVAGRVERLEYDPNRTAFIALITYEDGEQTYILAPQRLQVGDAVISADRADIKPGNAMPLKNMPVGTIIHNVEMKPGKGGQLARSAGCYAQLIGKDAGYAQLRLSSGELRLVRGECLATVGAVSNPDNQNEKLGKAGRSRWMGRRPHVRGVVMNPVDHPHGGGEGRTSGGRHPVTPWGKPTKGKRTRSNKKTDSLIMRSRHLAKKKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CYB_EUMGL
Sequence: MTNIRKSHPLIKIVNDAFIDLPAPSNISSWWNFGSLLGICLAVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLLRYLHANGASMFFICLYLHIGRGLYYGSYTYTETWNVGVILLFAVMATAFMGYVLPWGQMSSWGATVITNLLSAIPYMGTDLVGWIWGGFSVDKATLT
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: OPSD_ATHBO
Sequence: MNGTEGPYFYIPMLNTTGVVRSPYEYPQYYLVNPAAYAVLGAYMFFLILVGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTIYTSMHGYFVLGRLGCNVEGFSATLGGEIALWSLVVLAIERWVVVCKPISNFRFGENHAIMGVAFTWFMAAACAVPPLFGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVIYMFTCHFCIPLMVVFFCYGRLVCAVKEAAAAQQESETTQRAEREVTRMVIIMVVSFLVSWVPYASVAWYIFTHQGSEFGPLFMTIPAFFAKSSSIYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASSTASKTEASSVSSSSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: YP182_YEAST
Sequence: MKNPESSGVSSSPQIQRVSPSSSSTSPSPPSIGTSSCFTLSSCTLPIAAVVVAVDVVDIMSVDPLAMTSAFSISSLPTTGPLGTIAVDSITLLYTPICLCYLLVRLRKVNFEGNKLLMVSVVNFVPL
What are the official names of this protein?
Putative uncharacterized protein YPL182C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HPRK_TREPA
Sequence: MLKLDLKERDSLDLRCIAGHHGLANPITISDLNRPGLVLSGFFDFVAYRRIQLFGRGEHAYLLALLEQGRYGAIEKMFTFDLPCCIFSHGITPPEKFLHLAEPSSCPILVTRLTSSELSLRLMRVLSNIFAPTIALHGVLVEVYGVGILISGDSGVGKSETALELIERGHRLVADDLVEISCVNGNSLIGRGVHKSIGHHMEIRGLGIINITQLYGVGSIRERKEIQMVVQLEEWNSSKAYDRLGTQELNTTILDVSVPLIEIPVRPGRNIPIILETAAMNERLKRMGYFSAKEFNQSVLKLMEQNAAHAPYYRPDDTY
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr) (By similarity).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: RIMP_PROMM
Sequence: MPHPLLPDLETLASATAAGKGYKLCCVQVFTHLIPMTIQVQIRRKDGSDVSLDDCAHFSASMDEALEASQLFTEAYVLEISSPGIGDQLHSDQDFLTFRGFPVEISFRDHDSDLHQAGLLHKRSDEHVHINIKGRIQRIPRKAVTCVRLTNPTG
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_BURMS
Sequence: MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGDRIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQVAKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAVNIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALIRARTAIASLTGVNADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNAATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMGMGMDM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_NICSY
Sequence: MPIGVPKVPFRSPGEEDASWVDVYNRLYRERLLFLGQEVDSEISNQLIGLMVYLSIEDETKDLYLFINSPGGWVIPGVAIYDTMQFVRPDVHTICMGLAASMGSFILVGGEITKRLAFPHARVMIHQPASSFYEAQTGEFVLEAEELLKLRETLTRVYVQRTGKPLWVVSEDMERDVFMSATEAQAYGIVDLVAVE
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: PURA_ANADE
Sequence: MPNVVVVGAQWGDEGKGKIVDLLTQYADVVVRFQGGNNAGHTLVVGGEKTVLHLIPSGILHPGKSCVIGNGVVIDPEVLVLEIDRLKAKGALKDDGQLVVSLDAHVIMPWHKAIDVAREQAMGEGKIGTTGRGIGPTYEDKVARRGLRIRDLLDEARLARKVKERAALAREELARLGAKLELDEPALVKRYAELGRRVAGYATDVSIWLHRALQQGKSLLFEGAQGTMLDVDHGTYPFVTSSNTVAGNAVVGCGLGPTAVDYVLGISKAYSTRVGGGPYPTELKDETGERLRKIGGEYGATTGRPRRTGWLDALALRYAVRVNGLSGIAMTKLDVLTGFDTVKIAVGYRLDGKVLDEMPSDPEVIERCTPVYEELPGWTEKLEHLRTWDDLPPRARAYVKRVEELAGVKVVGCSVGADRGETILVENPFLAR
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_BRAHW
Sequence: MEEEIKETSEDKEEENTEAEAVENNEKSEENAGNVEEDEITALKKRIEELENESADMKNKYMYAMAEAENIRKRTAKEKADSIKRANKGLLLSLLTFMDNFERALKAGEQDSNVQGSEYYKGIELIHKQFIDFMHDNGVSEIESLGEEFDPNVHEALTMIEVPDIDKEKVVEVYAKGYKLNDELLRTAKVVVGKPAAAKE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.