PharMolix/UniProtQA huggingface dataset:
Protein: IGF1_PANTA
Sequence: MGKISSLPTQLFKCCFCDFLKVKMHIMSPSHLFYLGLCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKAQKEVHLKNASRGSAGNKNYRM
What is the function of this protein?
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.  May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts.  Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.  May play a role in synapse maturation.  Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb.  Acts as a ligand for IGF1R.  Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways.  Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4.  Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.  Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
What are the official names of this protein?
Insulin-like growth factor I, IGF-I, Somatomedin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: JKIP2_HUMAN
Sequence: MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSNRKHG
What are the official names of this protein?
Janus kinase and microtubule-interacting protein 2, CTCL tumor antigen HD-CL-04, Neuroendocrine long coiled-coil protein 1.
What is the protein family that this protein belongs to?
Belongs to the JAKMIP family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: NCAP_I97A1
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDQEGRLIQNSITIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAIKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQKAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPKENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVIPRGQLSTRGVQIASNENVEAMDSTTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERVTIMAAFKGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: MED15_ASHGO
Sequence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
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 15, Mediator complex subunit 15, Transcription regulatory protein GAL11.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 15 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIG_STRE4
Sequence: MSTSFENKATNRGVITFTISQDKIKPALDQAFNKIKKDLNAPGFRKGHMPRPVFDQRFGEEVLYEEALNIVLPAAYEGAVAELELDVVAQPKIDVVSMEKCQEWTLTAEVVTKPEVKLGDYKDLTVEVEASKEVTDEEVDAKVERERNNLAELVVKEEAAVEGDTVVIDFVGSVDGVEFDGGKGDNFSLELGSGQFIPGFEEQLVGAKAGDTVEVNVTFPENYQAEDLAGKAAKFVATVHEVKAKEVPELDDELAKDIDEEVETLDELKAKYRKELEASKEAAYDDALEGAAIELAVENAEIVELPEEMVHDEVHRSVNEFMASMQRQGISPDMYFQLTGTSQEDLHKQHEAEADKRVKTNLVIEAIAKAEGFEASDDEIEKEINDLAAEYSMPVEQVRSLLSADMLKHDIVMKKAVEVITSSAKAK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: TMPS2_MOUSE
Sequence: MALNSGSPPGIGPCYENHGYQSEHICPPRPPVAPNGYNLYPAQYYPSPVPQYAPRITTQASTSVIHTHPKSSGALCTSKSKKSLCLALALGTVLTGAAVAAVLLWRFWDSNCSTSEMECGSSGTCISSSLWCDGVAHCPNGEDENRCVRLYGQSFILQVYSSQRKAWYPVCQDDWSESYGRAACKDMGYKNNFYSSQGIPDQSGATSFMKLNVSSGNVDLYKKLYHSDSCSSRMVVSLRCIECGVRSVKRQSRIVGGLNASPGDWPWQVSLHVQGVHVCGGSIITPEWIVTAAHCVEEPLSSPRYWTAFAGILRQSLMFYGSRHQVEKVISHPNYDSKTKNNDIALMKLQTPLAFNDLVKPVCLPNPGMMLDLDQECWISGWGATYEKGKTSDVLNAAMVPLIEPSKCNSKYIYNNLITPAMICAGFLQGSVDSCQGDSGGPLVTLKNGIWWLIGDTSWGSGCAKALRPGVYGNVTVFTDWIYQQMRANS
What is the function of this protein?
(Microbial infection) Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9) and is involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
What are the official names of this protein?
Transmembrane protease serine 2, Epitheliasin, Plasmic transmembrane protein X.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Transmembrane protease serine 2 catalytic chain]: Secreted. Note=Activated by cleavage and secreted.
Protein: LPAT1_ARATH
Sequence: MDVASARSISSHPSYYGKPICSSQSSLIRISRDKVCCFGRISNGMTSFTTSLHAVPSEKFMGETRRTGIQWSNRSLRHDPYRFLDKKSPRSSQLARDITVRADLSGAATPDSSFPEPEIKLSSRLRGIFFCVVAGISATFLIVLMIIGHPFVLLFDPYRRKFHHFIAKLWASISIYPFYKINIEGLENLPSSDTPAVYVSNHQSFLDIYTLLSLGKSFKFISKTGIFVIPIIGWAMSMMGVVPLKRMDPRSQVDCLKRCMELLKKGASVFFFPEGTRSKDGRLGSFKKGAFTVAAKTGVAVVPITLMGTGKIMPTGSEGILNHGNVRVIIHKPIHGSKADVLCNEARSKIAESMDL
What is the function of this protein?
Plastidial enzyme of the prokaryotic glycerol-3-phosphate pathway that converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at position sn-2 (PubMed:15169931).  Utilizes palmitoyl-ACP (16:0-ACP) to produce phosphatidic acid containing a saturated group at position sn-2, which is characteristic of lipids synthesized by the prokaryotic pathway (PubMed:15169931).  In vitro, can use 16:0-CoA as acyl donor (PubMed:14976237).  Essential for embryo development during the transition from the globular to the heart stage when chloroplasts begin to form (PubMed:15169931, PubMed:14976237).
What are the official names of this protein?
1-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic, Lysophosphatidyl acyltransferase 1, Protein EMBRYO DEFECTIVE 1995.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: ST7L_HUMAN
Sequence: MADRGGVGEAAAVGASPASVPGLNPTLGWRERLRAGLAGTGASLWFVAGLGLLYALRIPLRLCENLAAVTVFLNSLTPKFYVALTGTSSLISGLIFIFEWWYFHKHGTSFIEQVSVSHLQPLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLNLFRGAEYRRYTWVTGKEPLTYYDMNLSAQDHQTFFTCDTDFLRPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALKAGETIYRQSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYPDVQAVLAKYDDISLPKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPLFIHFTAGFCSSTAMIAILTHQFPEIMGIFAKAVLGLWCPQPWASSGFEENTQDLKSEDLGLSSG
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein-like, ST7-related protein.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y258_XANOM
Sequence: MPTSMPNDPCPCGRPADYARCCGPYHAGAAAPDAETLMRARYSAHVRRDAAYLLASWHPSTRPGELSLDEGGRTTWLGLTVQRTLETGPETAEVVFLARYRIGGGSAVRMTEHSRFVRDAGRWYYLDAR
What are the official names of this protein?
UPF0225 protein XOO0258.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: AROB_PSET1
Sequence: MLELSVNLDERSYPIYIGQSTLQDNGRLVHHIGDCRPIIITNDTIAPLYLQGLLAQLATLNPLHFIIPDGEQYKSLTWFEKISAFLLENNCGRDTCLIALGGGVVGDLTGFVAACYQRGIPFIQMPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPQAVFIDTQSLHTLPAREFAAGMAEVIKYGLIYDTELFAYLEQNVERLQQLDEACLQHIIYRCCEIKALIVAQDEKEQGLRALLNLGHTFAHAIEAQMGYGVWLHGEAVATGMVLAAKLAYTRQDLTAEDVTRISGLIAQYSLPTQIPAVMTSEHFLQHMRKDKKNKKGTIRFILPTQFGQCALVDDVSDDQVRALIEQ
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARMC9_PONAB
Sequence: MGDILAHESELLGLVKEYLDFAEFEDTLKTFSKECKIKGKPLCKTVGGSFRDSKSLTIQKDLVTAFDNGDQKVFFNLWEEHIPSSVRDGDSFAQRLEFYLHIHFAIYLLKYSVGRPDKEELDEKISYFKTYLETKGAALSQTTEFLPFYALPFVPNPMVHPSFKELFQDSWTPELKMKLEKFLALIFKASNTPKLLTIYKENGQSNKEMLQQLHQQLVEAERRSMTYLKRYNKIQADYHNLIGVTAELVDSLEATVSGKMITPEYLQSVCVRLFSNQMRQSLAHSVDFTRPGTASTMLRASLAPVKLKDVPLLPSLDYEKLKKDLILGSDRLKAFLLQALRWRLTTSHPGEQRETVLQAYISNDLLDCYSHNQRSVLQLLHSKSDVVRQYMARLINAFASLAEGRLYLAQNTKVLRMLEGRLKEEDKDIITRENVLGALQKFSLRRPLQTAMIQDGLIFWLVDVLKDPDCLSDYTLEYSVALLMNLCLRSTGKNMCAKVAGLVLKVLSDLLGHENHEIQPYVSGALYSILSVPSIREEARAMGMEDILRCFIKEGNAEMIRQIEFIIKQLNSEELPDGVLESDDDEDEDDEEDHDIMEADLDKDELIQPQLGELSGEKLLTTEYLGIMTNTGKMRRKGLANVQWSGDEPLQRPVTPGGHRNGYPV
What is the function of this protein?
Involved in ciliogenesis.  It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity).  Acts as a positive regulator of hedgehog (Hh)signaling (By similarity).  May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity).
What are the official names of this protein?
LisH domain-containing protein ARMC9.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity). Localizes to the daughter centriole of the primary cilium in RPE1 cells (By similarity).
Protein: LEU1_BURCJ
Sequence: MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKNLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGIDTSQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHFKFVSLSQRSETGEQPQAKVVFAVEGKEVTGEARGNGPVDATFNAIEGEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYISALNKLHSKDDKVNPQRS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: PSBA2_SYNS9
Sequence: MTTTIQQRSGASSWQSFCEWVTSTNNRLYVGWFGVLMIPTLLAATICFVIAFVAAPPVDIDGIREPVAGSLMYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPFQLVVFHFLIGIYAYMGREWELSYRLGMRPWICVAYSAPVAAASAVFLVYPFGQGSFSDAMPLGISGTFNYMLVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTESESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGVSTMAFNLNGFNFNQSILDGQGRVLNTWADVLNRAGLGMEVMHERNAHNFPLDLAAAESTPVALQAPAIG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1 2, PSII D1 protein 2, Photosystem II Q(B) protein 2.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: CCA_BUCAI
Sequence: MKIYLVGGAVRDSLLNLPVKDKDWVVVGGTEKILLERNFQQVGKDFPVFLHPETHEEYALARKERKSGKGYTGFDTDCNSDVTLEEDLIRRDLTINAIAQDEYGNYIDPFQGKKDIECGLIRHVSESFIEDPLRVLRVARFAATLVHLGFKIAEETMLLMCIIVKKQELSYLTSNRIWNETEKALKTLNPHVYFQVLYECNALHFFFPEMYFLYEKKNFLNRSFFKKFCNKNIILMGLAEISLLNKDIDVRFSYLCQFLSVNQIDRNYSKIFFDSYAASIIHSVCKRFKIPSYIRDIAVLNTGFYFFLNTIHYQSSKNIINLFSKVDAWRKPDRVKKLAFLSNFNFLRNFKSEFFCIKSGCFLEKCFSVVKNVSIKLILKKGFKGYEIKQEITRLRIKKLEFWRIKNIKHRFYL
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 2 subfamily.
Protein: PRPE_BACMK
Sequence: MKYDIIGDIHGCFQEFQDLTTKLGYSWDSGIPIHNAKRRLAFVGDITDRGPHSLRMIEIVWELVINRKDAYYAPGNHCNKLYRFFLGRNVTIAHGLETTVAEYEALPSNKQQIIKEKFITLYEQSPLYHILDEKNLTVCHAGIRQDYIGRQDKKVQTFVLYGDITGEKHPDGSPVRQDWAKEYKGETWIVYGHTPVNEPRFVNHTVNIDTGAVFGGKLTGLRYPELETVSVPSSLPFVPEKFRPIS
What is the function of this protein?
Asymmetrically hydrolyzes Ap4p to yield AMP and ATP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical], Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the PrpE family.
Protein: YIDC_PSEAB
Sequence: MDIQRSILIVALAVVSYLLVLQWNKDYGQPELPAASASMNTTQGLPDTPSASGTSSDVPTAQSSAAGSEAADKPVAVSDKLIQVKTDVLDLAIDPRGGDIVQLGLLQYPRRLDRPDVPFPLFDNGRERTYLAQSGLTGADGPDASSAGRPLFHSAQSSYQLADGQNELVVDLSFSHDGVNYIKRFTFHRGLKADCSDKEKAQKKIECINENAYQVGVSYLIDNQSGKTWSGNLFAQLKRDGSADPSSTTATGVSTYLGAAVWTPDSPYKKISTKDMDKEQFKESVQGGWVAWLQHYFVTAWVPTKGEQHQVMTRKDGQGNYIVGFTGPTLSVPAGSKVETDLTLYAGPKLQKHLKELSPGLELTVDYGFLWFIAQPIFWLLQHIHSLIGNWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQAPWLGWITDLSVKDPFFILPIVMGGTMLIQQMLNPTPPDPMQAKVMKLMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQQWYITRKIEAAAKTA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OTU5A_XENLA
Sequence: MTILPKKKPPPPPDPEANGERSGSGAPDSHSRSGARPRSSPPPRWAYPGNPSSAAERHTQQVSPPPGSATSGGAGPLGDGALGSCCCCNGAGAGGCCSGPGHSKRRRQVLSAGPGATGNCPDTDDGAGNNSEDEYETAAQTQHLDPDTAEQQELCFEKTLSDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYGTEPINTFHGIQKNEDEPIRVSYHRNIHYNSVVNPNKATIGVGLGLPSFKPGYAEQSLMKSAIRTSEESWIEQQMLEDKKRATDWEATNEAIEEQVARESYLQWLRDQEKQARQPRKASATCSSATAAACSGLEEWSGRSPRQRSTAGSPEHPDLHAELCMKPPSPGAPLILGKPPSPCAPGPSNQMSTGADRATSPLVSLYPALECRAIMQHMSPTAFGLKDWDNDEILASVLAASQQEYLDTMKKSTLRRESSPDHS
What is the function of this protein?
Deubiquitinating enzyme that may function as negative regulator of the innate immune system.  Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.  Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity).
What are the official names of this protein?
OTU domain-containing protein 5-A, Deubiquitinating enzyme A, DUBA.
What is the protein family that this protein belongs to?
Belongs to the peptidase C85 family.
Protein: RUVA_THISH
Sequence: MIGRLRGELVSKQPPFLLLDVQGVGYEIEAPLSTFYDLPEPGGQVTLHTHLHVREDAHVLYGFASESERALFRSLIKVTGVGAKMALAILSGMTASEFSRCVMDGDVASLVRLPGIGRKTAERLVVEMRDRLGSLPAAVTLTGGKPAAAAARAPDPVSDAVSALVSLGYKPQEASRLISAVEGEAERSEDLIRLALKATLK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: YELL_DROSI
Sequence: MFQDKGWILVTLITLVTPSWAAYKLQERYSWNQLDFAFPNTRLKDQALASGDYIPQNALPVGVEHFGNRLFVTVPRWRDGIPATLTYINMDRSLTGSPELIPYPDWRSNTAGDCANSITTAYRIKVDECGRLWVLDTGTVGIGNTTTNPCPYAVNVFDLTTDTRIRRYELPGVDTNPNTFIANIAVDIGKNCDDAYAYFADELGYGLIAYSWELNKSWRFSAHSYFFPDPLRGDFNVAGINFQWGEEGIFGMSLSPIRSDGYRTLYFSPLASHRQFAVSTRILRDETRTEDSYHDFVALDERGPNSHTTSRVMSDDGIELFNLIDQNAVGCWHSSMPYSPQFHGIVDRDDVGLVFPADVKIDENKNVWVLSDRMPVFLLSDLDYSDTNFRIYTAPLATLIENTVCDLRNNAYGPPNTVSIPKQAVLPMGPPLYTKQYRPLLPQKPQTSWASSPPPPSRTYLPANSGNVVSSISVSTNSVGPAGVEVPKAYIFNQHNGINYETSGPHLFPTHQPAQPGVQDGGLKTYVNARQSGWWHHQHQG
What is the function of this protein?
Controls the pigmentation pattern of the adult cuticle and larval mouth parts.
What are the official names of this protein?
Protein yellow.
What is the protein family that this protein belongs to?
Belongs to the major royal jelly protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: GTPB3_MOUSE
Sequence: MWRGLSALVTQAAWAPLRLCARCSTSAESLVPSSTIFALSSGQGRCAIAVIRTSGPASGLALRSLTALQEPPPARRACLRLLRHPCSGEPLDRSLVLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFAHGKLSLTEVEGLADLIRAETEAQRRQALRQLDGELSQLCQGWAKTLTKALAYVEAYIDFGEDDNLEEGVLEQADREVRALEVALGSHLRDARRGQRLLSGANVVVTGPPNAGKSSLVNLLSQKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLREGVGAVEQEGVRRARHRLEQADIILGVLDASDLASSSSCSFLDTVVTPLLAQSQDSGGQRLLLLLNKSDLLSANAPACDIALPPHLLLSCHTGAGMDSLLQALKTELAAVCGDPSTGPPLLTRVRHQYHLQGCLDALGHYQLATDLALAAEALRQARRQLNHLTGGGGTEEILDLIFQDFCVGK
What is the function of this protein?
GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
What are the official names of this protein?
tRNA modification GTPase GTPBP3, mitochondrial, GTP-binding protein 3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Mitochondrion.