PharMolix/UniProtQA huggingface dataset:
Protein: CAV2_ATEGE
Sequence: MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFADSGQDRDPLWLNSHLKLGFEDVIAEPVTTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFLAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDAIISPLCMSIGRSFSSVSLQLSQD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Protein: METK_GEOSL
Sequence: MEMKDYIFTSESVSEGHPDKVADQVSDAILDAILTQDKRARVACETLVTTGMAVIAGEITTTAVVDYPKVVRETIKEIGYNDSAMGFDWETCAVLVSIDKQSPDISQGVTEGEGMFKEQGAGDQGLMFGYACNETPELMPMTIMYSHRLTQKLAEVRKNGTLDFLRPDSKSQVSIQYVDDRPVRVDTVVISSQHTPEVSYETIKEGIIEEVVKKIIPVELMDDKTRFLINPTGRFVIGGPMGDCGLTGRKIIVDSYGGHGAHGGGAFSGKDPSKVDRSAAYMGRYVAKNLVAAGLCERCEVQVAYAIGVAEPVSVMVDTAGTGKIPSARIAEIIREVFDLRPRAIIEQLDLLRPIYRKTAAYGHFGRELPEFTWERTDKIDIIRQKAGI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_SORC5
Sequence: MPKEKARPGETLIARNKRAGFNYDLGDRFEAGIVLKGSEVKMLRAGKADLTDSFCTVLRGEVFLHGVSIAAMASAAFGHVPKGARKLLLHRREIERIDLSIAREGMTAVATRLYFKSGLAKVEIALARGKKSHDKRETIKEQDAEREMRAVVVHGQRGYGRA
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: URE2_STRCO
Sequence: MIPGEILFADEPVAFNEGREAVRLTVLNTADRPVQVGSHYHFAEANPGLEFDRAAAHGRRLDIAAGTAVRFEPGIPVDVRLIPLAGARVVVGLRGATGGALDA
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_ANASK
Sequence: MSQARFIAFSDGSALVNPGGPGGTGFVVLDRARPAYRFGGTRWVEDGPNAVTNNRMELRAVLEALEGLPGGEQVEVISDSRYVVDALSRWIHGWRKKGWRTASGEPVLNRDLIEALDARASALSVRYTWVRGHDGHAVNEVVDQLAQAAARGVAGPGEAEVVAALRAEAFLAGGPAAPRSSRA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_CYTH3
Sequence: MKYNEKKTELSEVGKEVQQFWNDKKIFEKSVETREGNPTFTFYEGPPSANGTPGIHHVMGRTVKDIFCRFKTMQGFQVKRKGGWDTHGLPVELQVEKELGITKEDIGKKITVEQYNQKCREAVMKYKSQWDELTVKMGYWVDLEKPYITFENNYIESVWYLLKEFHQKKLLYKGYTIQPYSPAAGTGLSSHELNQPGTYKDVRDTSAVAQFKLKANPKFADNTYFLAWTTTPWTLPSNSALAVGENIEYVLVSTFNPYTFKPVQVILAKALLGKYFSEKAKDLSLEAYKDGDKLIPFKILQSYKGKDLVGIEYEQLMPYLQPETPAFRVIAGDFVSTEDGTGIVHIAPTFGADDARVAKLAGIPSIVTKDDRGNEYPLVDKRGRFTKEVTDFAGEYVKEAYLTDEEKEAERVKQGRDKYLSVDERISIKLKEANRAFKVEKYEHSYPHCWRTDKPVLYYPLDSWFIKTTAKKERLVELNKTINWKPESTGVGRFGNWLENLVDWNLSRSRYWGTPLPIWRSEDGSEEKCIGSIEELKTEIAKAQKAGIETATDIKDLHRPYVDNIVLVSDSGKPMKRELDLIDVWFDSGAMPYAQWHYPFENKELFNNNYPADFIAEGVDQTRGWFFTLHAISGMLYDKVAFKNVIANGLVLDKNGNKMSKRVGNVVNPFETIDKYGPDATRWYMITNAPPWDNLKFNLDGITEVQRRFFGTLQNTYSFFALYANLDNFTFAEAEIPLAQRTESDRWILSKLQSLVKDVADAYSDYEPTKAGRAIQDFVVDDLSNWYVRLNRKRFWKGEYNADKTAAYQTLYTCLETVAKLGAPIAPFYMDKLFSDLNQVSKKNAVESVHLADFPKVNEAFLDVELEERMSLAQRISSLVHSIRKAQTIKVRQPLSRILIPILQPHLKAQIQAVEDLIKNEVNIKAVEYIEDTSGVVIKTIKPNFKKLGKEYGAKLKEIGNAIAELRAEDITAIERNVFELKLADGTVIPITSEDVEIRSQDIPGWSVASEGGITVALDITLSDDLRKEGIARDVVNRVQNLRKDMGLEVQDKIRITIQKVDELINSALSANQEYICTETQAFSLELVEKLADGKEVEMDEQTLIMKIEK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4547_NOSS1
Sequence: MFTIDLSIKNTAFPITVQRKTAEDAEAVYQLILAAIRSGNPDIVELKCEGKTEKKIAVRASEISGVQITQKDGVTTSSGRAPGFFALAGE
What are the official names of this protein?
UPF0367 protein asl4547.
What is the protein family that this protein belongs to?
Belongs to the UPF0367 family.
Protein: PCAT1_DANRE
Sequence: MRFPNRKLHTAVNGGDSGVSTHFRNPFVHELRFTTLQKLKIAVMTVTLFPVRLLFAAFMMLLAWPFAFVATVGRSENAVEPLSWWRWLVDLALKAIMRAMWFSGGFHWVRVKGRPALPSEAPILTMAPHSSYFDAIPVTMTMASIVMKAESKDIPVWGTLIKFIRPVFVSRSDQDSRRKTVEEIKRRASSNGEWPQIMIFPEGTCTNRSCLIAFKPGAFIPGVPVQPVVLRYPNELDTISWTWQGPGAFKILWLTLCQLHNFVEIEYLPTYTPSEEEKKDPALFASNVRRIMAKALGLPIIDYSFEDCQLAMAKGPLRLPKHTCLLEFARLVRLLGLKTKVTDEVLQEEACSARQLCGRRLDMEGFAQYLHQPMTEAVQDIFSLFEEHGMMDVREYVIALSVVCRPFRYLDTVKLAFRMFEAQEDGAIVEDELTVILKTALGVGDLAVSELFRAIDSQDKGKITFDELCSFMEKCPDLVEQYHCLCESISQHSRESTSSSNGFCADFSPRNHSKKQD
What is the function of this protein?
Exhibits both acyltransferase and acetyltransferase activities (By similarity).  Activity is calcium-independent (By similarity).  Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity).  Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).
What are the official names of this protein?
Lysophosphatidylcholine acyltransferase 1, LPC acyltransferase 1, LPCAT-1, LysoPC acyltransferase 1, 1-acylglycerol-3-phosphate O-acyltransferase, 1-acylglycerophosphocholine O-acyltransferase, 1-alkenylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase, Lyso-PAF acetyltransferase, LysoPAFAT, Acyltransferase-like 2.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Lipid droplet. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.
Protein: TF2AA_PONAB
Sequence: MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFHSEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRVANGAQYIFQPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQITATGHQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW
What is the function of this protein?
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.  TFIIA in a complex with TBP mediates transcriptional activity (By similarity).
What are the official names of this protein?
Transcription initiation factor IIA subunit 1, General transcription factor IIA subunit 1.
What is the protein family that this protein belongs to?
Belongs to the TFIIA subunit 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CO1A2_CHOHO
Sequence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
What is the function of this protein?
Type I collagen is a member of group I collagen (fibrillar forming collagen).
What are the official names of this protein?
Collagen alpha-2(I) chain, Alpha-2 type I collagen.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.
Protein: RPOB_THEM4
Sequence: MKEIKRGKRTRYSFERVQTPIPVPNLVEIQTKSYQDFLENGILKVLKKFSPITSSKSDLRKEKGFSLEFVSVRIGEPQNTVQECKERLLTYTVPVYTTVRITDNSTNEMIEEEAFLGYIPYMTPRTTFIINGAERVVVNQLVRSPGIYFVEEAKKTSGTKPIYVAHFLPVRGAWLEILLNLNDEVFYARIDRKRRINLFLLLKALGYSEDLELLSLFPYWIDVEDEYTLQHSEGLIILEDVKTKNGGLIAKRGDVITQGLIEKLENSDIQKIKVAHRYAVNTLEKLNHVYGENIEENRAYIEIFRKLRPGELPRINAAKIFLRNLYFNEERFELSEVGRFKMNNRLEEAYRKYLIEVEGKDPQGVEEVKYDETSNVLTPMDIVLASRNLIEIDKHPGTMDTKDHLGNKRVRTVGELIRIEFERAFSKAVFMIQEKLATYTSLDKISVQSLINVKSIIATINSFFATNPLSQFMDQTNPLAELTHKRRLTAVGPGGLKRERARFEVRDVHHSHYGRMCPIETPEGANIGLITSLSVYSSIDKFGFLITPYVKVVKGKVTNEIVYLTADEEENYKIAPSTIPIDEKGNIIPENVTVRYEEKVLYVNKNNVQFIDVAPNQIVSVSTSLIPFLEHDDANRALMGSNMQRQGVPLIETEAPRVGTGMEWEAAKYSGTLILAKHDGIVKKVDAQKIVIHRIDENGKEMYDSMGNPMLDIYELLKFTRTNQDTCINQRPIVNVGEIVKKDEPIADGPATDMGELALGKNVLVAFVPWEGYNFEDAILISEELLEKETYTSIHIEVYETTARDTRLGPEEITPDIPNVSKEKLRNLDEDGIIRIGAYVQETDILVGKVTPKSESDTTPEEKIIRSVFGEKGKEVKDTSLRVPHGIEGRVIAVHVFDKEKDGDLGPGVNKLIRVYVAIRKPLEVGDKLAGRHGNKGVVSKILPKEDMPFLPDGTPIQVVLSPLGVPSRMNVGQILETSLGWLAMLTNRWFATPVFDGAKEGDILPELYKARKKFGLEMGDFEENPSGKVILRDGRTGKEFDHPILVGYMYVMKLIHIARDKIHARSTGPYSLIHQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLNEMLTVKSDDIRGRNEVYKAIMKGKNIPEPGLPESFKVLVRELRGIALDVRVYDDEGNEIDIEKL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: OL142_ARAHY
Sequence: MATATDRAPHQVQVHTPTTQRVDVQRRGYDVSGGGVKTFLPDRGPSTSQIIAVLVGVPTGGTLLLLSGLSLLGTIIGLAIATPVFTFFSPVIVPAVVTIGLAVIGILTAGACGLTGLMSLSWMINFIRQVHGTTVPDQLDSAKRRMADMADYVGQKTKDAGQEIQTKAQDVKRSSS
What is the function of this protein?
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil.  Probably interacts with both lipid and phospholipid moieties of lipid bodies.  May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
What are the official names of this protein?
Oleosin Ara h 14.0102, Oleosin 5 variant B.
What is the protein family that this protein belongs to?
Belongs to the oleosin family.
What are the subcellular locations of this protein?
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface.
Protein: FAD3C_RICCO
Sequence: MAAGWVLSECGLRPLPRIYSRPRIGFTSKTTNLLKLRELPDSKSYNLCSSFKVSSWSNSKQSNWALNVAVPVNVSTVSGEDDREREEFNGIVNVDEGKGEFFDAGAPPPFTLADIRAAIPKHCWVKNPWRSMSYVLRDVVVVFGLAAVAAYFNNWVAWPLYWFCQGTMFWALFVLGHDCGHGSFSNNPKLNSVVGHLLHSSILVPYHGWRISHRTHHQNHGHVENDESWHPLSEKIFKSLDNVTKTLRFSLPFPMLAYPFYLWSRSPGKKGSHFHPDSGLFVPKERKDIITSTACWTAMAALLVYLNFSMGPVQMLKLYGIPYWIFVMWLDFVTYLHHHGHEDKLPWYRGKAWSYLRGGLTTLDRDYGWINNIHHDIGTHVIHHLFPQIPHYHLVEATEAAKPVMGKYYREPKKSGPLPLHLLGSLVRSMKEDHYVSDTGDVVYYQKDPKLSGIGGEKTE
What is the function of this protein?
Chloroplast omega-3 fatty acid desaturase introduces the third double bond in the biosynthesis of 16:3 and 18:3 fatty acids, important constituents of plant membranes.  It is thought to use ferredoxin as an electron donor and to act on fatty acids esterified to galactolipids, sulfolipids and phosphatidylglycerol.
What are the official names of this protein?
Omega-3 fatty acid desaturase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Peripheral membrane protein.
Protein: CDKA_CONVX
Sequence: MPKLEMMLLVLLIFPLSYFIAAGGQVVQVDRRGDGLAGYLQRGDRDVQDCQVSTPGSKWGRCCLNRVCGPMCCPASHCYCVYHRGRGHGCSC
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=370 nM) and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes.  VxXXB inhibits alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR subtypes with the highest efficiency, followed by VxXXA and VxXXC.  VxXXB and VxXXC inhibit the alpha-4-beta-2/CHRNA4-CHRNB2 nAChR subtype more efficiently than VxXXA.
What are the official names of this protein?
Alpha-conotoxin VxXXA, Vx20.1, VxXIIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin D superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM_BURTA
Sequence: MSASDLHPVQAGAPQGRRQILVTSALPYANGQIHIGHLVEYIQTDIWARTMRMHGHEIYYIGADDTHGTPVMLRAEQEGVSPKQLIERVWREHKRDFDSFGVSFDNFYTTDSDENRVLSEKIYLALKEAGFIAEREIEQAYDPVKQMFLPDRFIKGECPKCHAKDQYGDSCEVCGTTYQPTDLVNPYSVVSGATPVRKTSTHHFFRLSDPRCEAFLREWVSGLAQPEATNKMREWLGDAGEAKLADWDISRDAPYFGFEIPGAPGKYFYVWLDAPVGYYASFKNLCERRGLDFDAWISKDSTTEQYHFIGKDILYFHTLFWPAMLEFSGHRTPTNVFAHGFLTVDGAKMSKSRGTFITAQSYIDAGLNPEWLRYYFAAKLNATMEDIDLNLEDFQARVNSDLVGKYVNIASRAAGFLIKRFDGRVQASATNHPLLVTLRDAIPQIAAHYEAREYGRALRQTMELADAVNGYVDTAKPWELAKDPANAVALHETCTVSLEAFRLLSLALKPVLPRVAEGVEAFLGIAPLTWADANKPLSSEQPIRAYQHLMTRVDPKQIDALLAANRSSLQGAAAADAAGATNGNGAKAAKSAKAANAASADDEASPFISIDDFAKIDLRIAKIVACQAVEGSDKLLQLTLDVGEEKTRNVFSGIKSAYQPEQLVGKLTVMVANLAPRKMKFGLSEGMVLAASAADEKAEPGLYILEPHSGAKPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_BUCAI
Sequence: MAKYLGPKLKLSRREGTDLFLKSGLRSIESKCKLEQPPGQHGIRKPRLSDYAIQLREKQKVRRLYGVLERQFKIYYKLAASLKGNTGANLLQLLESRLDNVVYRMGFGCTRSESRQLINHKSIMVNNKVVNIASYQVSPNDQISIRNKSKNQSRIKAALELVEQREKPIWLEVNSTKMEGIFKRFPERSDLSAEINEYLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NOD2_PANTR
Sequence: MGEEGGSVSHDEEERASVLLGHSLGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLHGCWDPHSLHPARDLQSHRPAIVRRLHNHVENMLDLAWERGFVSQYECDEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTYDGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGRDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHREPGVADRLIRLLQATSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQGSEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPAECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAQGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLGCRDTRLLL
What is the function of this protein?
Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity.  Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling.  This in turn leads to the transcriptional activation of hundreds of genes involved in immune response.  Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages.  Component of an autophagy-mediated antibacterial pathway together with ATG16L1.  Also plays a role in sensing single-stranded RNA (ssRNA) from viruses.  Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon.  Besides recognizing pathogens, participates in surveillance of cellular homeostasis through sensing and binding to the cytosolic metabolite sphingosine-1-phosphate and then initating inflammation process.
What are the official names of this protein?
Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Basolateral cell membrane.
Protein: BRK3_PELRI
Sequence: RPPGFDPFR
What is the function of this protein?
Induces relaxation of arterial smooth muscle, by targeting bradykinin receptors (BDKRB).
What are the official names of this protein?
[Asp6]-bradykinin.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: PGA52_CANAL
Sequence: MLFSSLLVSTLVSVATAANQEVEAIQFSNLGFSGTYNQVEKLSNIYKDSCSCEVNKTPVSFSGTNAPLNEEVSVHFRGPLVLNKFASYVSDGFKYGDDSSGDWKRLSYYEGSSGTSENVTFLTSAGKNSSCLGIGLTYAGTDGISKADSSTVLAKNTLINSNDEFVIFSNISCGKSGYNNDCGVYRSDIPAYHGFYGTTKMFLFEFQMPNETHTSTDISNYNMPAIWLLNAHIPRTAQYSMNVNCSCWRSGCGEFDIFEVMNSTEYLHMYSTIHDYQGSDDIQTGMAAPAYIERDLTGTMSGGVAFDSSGNAVVWVSNSTSFDSTIQASSVNSWVKQAGADVATTLATVTGQSATTTSKKSGGVSYQPSFITNLLMTVLTLWVI
What are the official names of this protein?
GPI-anchored protein 52.
What is the protein family that this protein belongs to?
Belongs to the PGA52 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.