PharMolix/UniProtQA huggingface dataset:
Protein: PANK2_MOUSE
Sequence: MGGWLGRQRRLLRMGAGRFGAPMERQGRAAATSAAVGESADSEARRRDPLRRRASSAAPSGSGEAESVRRERPGSLGGSTSAGRPRAEGLRKRRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEKEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGRDKNFSSLHTVFCATGGGSYKFEQDFLTIGDLQLRKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCSTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAASKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRVNTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELLKIP
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
What are the official names of this protein?
Pantothenate kinase 2, mitochondrial, hPanK2, Pantothenic acid kinase 2.
What is the protein family that this protein belongs to?
Belongs to the type II pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: FETP_BURA4
Sequence: MARMIQCAKLGKEAEGLDFPPLPGELGKRIYESVSKEAWQGWLKQQTMLINENRLNMADPRARQYLMKQTEKYFFGDGADQASGFVPPTEG
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: SGK3_PONAB
Sequence: MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
What is the function of this protein?
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration.  Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1. 3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.  Plays a role in the regulation of renal tubular phosphate transport and bone density.  Phosphorylates NEDD4L and GSK3B.  Positively regulates ER transcription activity through phosphorylation of FLII.  Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase Sgk3, Serum/glucocorticoid-regulated kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Protein: MEX3A_HUMAN
Sequence: MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAAIDSRYSDAWRVHQPGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSSAKARAGPPGAHRSPATSAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS
What is the function of this protein?
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.
What are the official names of this protein?
RNA-binding protein MEX3A, RING finger and KH domain-containing protein 4.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.
Protein: AGRA1_MOUSE
Sequence: MTQWDLKTVLSLPQYPGEFLHPVVYACTAVMLLCLLASVITYILHQSAIRISRKGRHALLNFCFHAALTFTVFAGGINRTQHPILCQAVGIALHYSTLSTMLWIGVTARNIYKQVTKKALPCPGADQPPYPKQPLLRFYLISGGVPFIICGVTAATNIRNYGTEDEDVAYCWMAWEPSLGAFYGPAAFIALVTCVYFLCTYVQLRRHPERRYELRERTEEQQRLAVPESGHRHGVRPGTPPTCDALAASQLQNEHSFKAQLRAAAFTLFLFTATWTFGALAVSQGHFLDMIFSCLYGAFCVTLGLFVLIHHCAKREDVWQCWWSCCPSRGDTSTTKPGAHPTLDANGDALGHTACLQDSPCPGKLRGFGHPPASHCKMTNLQAAQGHVSCLSPATPCCAKMHCEQLMEEEAAHIHMAEEDVYPHDPHLHDPHLHRCLKGRTKSHYFSRHQAAAAEREYAYHIPSSLDGSPHSSRSESPTSSLEGPMGMHTLACCAQADPFPMVSQPEGGDTSPGLYGCPPHLSPGPAHLEMLRRTQSLPFGGPSQNGLLQGDVREGLPFGTDGTGNIRTGPWKNETTV
What are the official names of this protein?
Adhesion G protein-coupled receptor A1, G-protein coupled receptor 123.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL29_DINSH
Sequence: MNAQELRDKTPDELRDQLAALKKEAFNLRFQQATGQLENTARMRSVRRDVARVATILTEKAAAAAATE
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: PSBK_PARMW
Sequence: MASFTLDLLAQLPEAYQAFSPLIDILPLIPVFFLLLAFVWQASVGFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: NAGB_BLOFL
Sequence: MKVVFLDNTDQVAQWVSGYIIWKINSFKPTISRPFLLGLPTGSSPIKTYKNLIKLYQDGQVSFKYVVIFTMDEYIGISSDDPTSYCKFLHDNFIDHIDIAQENVNFLNGNVTDLNYECERYEKKIKSYGNIHLFIGGVGKDGHVAFNEPGSSFNSRTRVKNLSRETRLSNARFFSYKIEAVPKFALTIGLATLLESQEIIIIATGQDKAAAVQAAIEGSVNHTWPISCLQFHPKTTLICDELSTVELKIKTVKYFQELEVNNNKIFN
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: DAA11_XENTR
Sequence: MVRVSEDLIRRRAEHNNCEIFSLEEISLHQQDLERIEYIDKWCRELKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCESLQKLDLTVNFVGDLSSINSLQENRQLREFYLVGNPCAEYEGYRQYVVATLPQLKWLDGKEIERSERIQAAQDYPQVQGKIKEQEEAYLRKRAAEREKATNNLQQKQKEGRKAQEKKPGFDRRWYTDINNTIPDPVEKTDTVAQLNVDETALRNDDEEEEKEFWNQPSQYTPESRLETHRYLEEKRKSKENRSEEELKKKPPRTLITAEGRVLNVNESKLDFSLVDDEENNQFVLDLAIYRHLDTSLLDVDVQPGYIKVLVKEKPFQLVLPAEVKPDSSAAKRSQTTGHLVVTMPKATEMIQTKRAKSPAIAERTCKNPQKCLKTHEKLEVDPKARSIPDVANIVQEKKTWAQGPLRLHRNSARDTADSEDFIDNAEVPPLV
What is the function of this protein?
Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia.
What are the official names of this protein?
Dynein axonemal assembly factor 11, DNAAF11, Leucine-rich repeat-containing protein 6, Protein tilB homolog.
What is the protein family that this protein belongs to?
Belongs to the tilB family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium. Dynein axonemal particle. Cell projection, cilium, flagellum. Note=Localized to cytoplasmic puncta in ciliated cells. In the semicircular canal, localized to kinocilia (By similarity).
Protein: CYB_PELPL
Sequence: MAPTIRKSHPLLKIINGSFIDLPSPANISAWWNFGSLLGVCLIAQIATGLFLAMHHTADTSLAFSSIAHICRDVNNGWLLRNLHANGASFFFICIYFHIGRGLYYGSYLYKETWNIGVILLFLVMATAFVGYVLPWGQMSFWGATVITNLLSAAPYIGPDLVQWIWGGFSVDNATLTRFFTFHFILPFIIAAASMINLLFLHQTGSSNPTGLNSNLDKVSFHPYFSYKDLLGFVIMLGALASLSTFAPNLLGDPDNFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLLSIMILFLMPIIHTSKLRSLMFRPIAKTFFWALIANTAILTWIGGQPVEDPFITIGQIASGLYFLIFVLLIPSLGLLENKLLKI
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SRY_CERNI
Sequence: MFRVLNDDVYSPAEIQQQNPLAFGKASSLFTDNRSANDQCETGENVRESGQDHVKRPMNAFIVWSRERRRKVALENPQMQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAVHRDKYPGYKYRPRRKTKRQQKLLPADSSKQCKQMHIETLQPFTYRYGCANTTGSRMESQLSLSQSVTITNSFFQNEHHSSWTNLGHNRVTLATQISADFPFYQSLQPGLSCAYFQY
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: RSMH_ALKOO
Sequence: MDFKHVSVLLEECIENLNIKENGIYVDGTLGGAGHSSEIAKRLSDKGLLIGIDQDENAIKAAGEKLTPMKERIKLVRDNFSNIDAILQNLEIDGIDGILLDLGVSSHQLDEADRGFSYMHDAPLDMRMDTRQAVSAMEVVNSYTEKDLENIIKNYGEEKWAKRIANFIVDFRKEEPITTTHQLVDVIKRAIPKGARIDGPHPAKRTFQAIRIEVNGELEIINKTIDDAVRNLNPGGRICIITFHSLEDRIVKNAFRDLSNPCICPPEFPICRCDRKPAVKIITRKPIVPTEEELELNPRARSAKLRVAEKI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC24_ARATH
Sequence: MEMSLTDSDWDSSSDSGSSEHEEVEFSYGGRAQNIFSNLEETIGKIDEFLSFERGFMYGDIVRSATEPSGQSGRVINIDMFVNLESTHGKIMKEVDTKRLQKLRSISLSDYVINGPWVGRVDKIVERVSVTLDDGTNYEVLVDGQDKLVAIPPNLLEDSQYSYYPGQRVQVKLAHAPRSTTWLCGTWRGTQVMGTVCTVEAGLVYVDWVASIVMEGDRNLTAPQALQNPESLTLLPCVSHASWQLGDWCILPGSSHCDIAERQTPNVAAYNLNECHKTFQKGFNRNMQNSGLDELFVITKTKMKVAVMWQDGSCSLGVDSQQLLPVGAVNAHDFWPEQFVVEKETCNSKKWGVVKAVNAKEQTVKVQWTIQVEKEATGCVDEVMEEIVSAYELLEHPDFGFCFSDVVVKLLPEGKFDPNADTIVATEAKHLLTESDYSGAYFLSSIGVVTGFKNGSVKVKWANGSTSKVAPCEIWKMERSEYSNSSTVSSEGSVQDLSQKISQSDEASSNHQETGLVKLYSVGESCNENIPECSSFFLPKAAIGFITNLASSLFGYQGSTSVISSHSRCNDSEDQSDSEVLVQETAESYDNSETNSGEVDMTTTMVNIPIEGKGINKTLDSTLLENSRNQVRFRQFDMVNDCSDHHFLSSDKGLAQSQVTKSWVKKVQQEWSNLEANLPNTIYVRVCEERMDLLRAALVGAPGTPYHDGLFFFDIMLPPQYPHEPPMVHYHSGGMRLNPNLYESGRVCLSLLNTWSGSGTEVWNAGSSSILQLLLSFQALVLNEKPYFNEAGYDKQLGRAEGEKNSVSYNENAFLITCKSMISMLRKPPKHFEMLVKDHFTHRAQHVLAACKAYMEGVPVGSSANLQGNSTTNSTGFKIMLSKLYPKLLEAFSEIGVDCVQEIGPES
What is the function of this protein?
E2 ubiquitin-protein ligase that mediates E1-dependent protein ubiquitination (PubMed:24474629).  Mediates PHO1 degradation through multivesicular body-mediated vacuolar proteolysis in response to inorganic phosphate (Pi) availability (PubMed:22634761).  Negatively regulates the protein abundance of PHF1 and PHT1s under Pi-sufficient conditions by facilitating the degradation of PHT1 proteins at the endomembrane (PubMed:24122829, PubMed:22634761).  Functions cooperatively with NLA to regulate the abundance of the inorganic phosphate (Pi) transporters PHT1-1, PHT1-2 and PHT1-3 in different subcellular compartments (PubMed:24122828).  Regulates Pi homeostasis by mediating, cooperatively with NLA, polyubiquitination of PHT1-4 and its targeting for degradation (PubMed:24474629).
What are the official names of this protein?
Probable ubiquitin-conjugating enzyme E2 24, AtPHO2, E2 ubiquitin-conjugating enzyme 24, Ubiquitin carrier protein 24, Ubiquitin-protein ligase 24.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Golgi apparatus membrane. Endoplasmic reticulum membrane.
Protein: U23_HHV6Z
Sequence: MRKSEFNAKSCFLMIGICVFNLNSSSCIIKTNAEHCSKRLFSFCYLGVGVIKKPLHLGNRKNMLFLSFLLVCLCEEVQMLNLTTTEVSATEFASIASKNMETNVSTSSDYLTGKSETTFSANPETWGKNVTEISIASVAYLNQSSMVTSTLAVGTTNRSSGNNVNVTTSSFPTVKGDEAQDIETFFTVILASTLSDVSEKTPQGLPTKSTPKKTVQALWETDTVQVPELTDTNEGDEEYFKDFLSSLVIWICGISFVGAFIIVIVILYNWYKKDKQRSLLWDEENKPDVQIRRDAKTCR
What are the official names of this protein?
Protein U23.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: LFTR_MAGSA
Sequence: MRPLTADLLLRAYASGVFPMARSRDENRLYWVDPEQRGILPLEAFHVPKSLRRTLRSERFDIRCDTAFEAVMRACGEATADRPETWINEQIIRLFVELFELGLGHSVEVWQDGELVGGLYGLALGAAFFGESMFSRRTDASKVALVHLVARLRHGGFRLLDTQFVTEHLKQFGAQEISRAAYQDRLADALAETAWFDRNATVAWEVALV
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLXB2_MOUSE
Sequence: MALPLWALTFLGLTGLGLSLRSRKPESFRSETELNHLAVDEVTGVVYVGAVNALYQLSADLHVQQHVVTGPFMDNKKCTPPIEASQCHEAVLTDNFNQLLLLDPPGKRLVECGSLFKGICALRAMSNISVRLFYEDGSGEKSFVASNDERVATVGLVTSTRPDGERVLFVGKGNGPHDNGIIVSTRLLDRAEGREAFEAYSDHTTFKAGYLSTNTQQFVAAFEDDFYVFFVFNHQDKHPAKNRTLLARMCKDDPSYYSYVEMDLQCQDPSDPQDSAFGTCLAASVATSGAGRALYAVFSRDGRSTGGPGAGLCVFPLDKVREKIEANRNACYTGAREAGRTIFYKPFHGEIQCGGHLIGASESFPCGSEHLPYPLGSRDGLVATAVLHRGGLNLTAVTVTAENDHTVAFLGTSDGRILKVYLAPDGTSAEYGSIPVDINKKIKQDLALSGNLSSLYAMTQDKVFRLPVQECLSYVTCAQCRDSQDPYCGWCVIEGRCTRKSECSRAEETGHWLWSREKSCVAITDAFPQNMSRRAQGEVRLSVSPLPTLTEDDELLCLFGDSPPHPARVEDDTVICNSPSSIPSTPPGQDHVDVSIQLLLKSGSVFLTSHQYPFYDCREAMSLVENLPCISCASNRWTCQWDLQYYECREASPNPEEGIIRAHMEDNCPQFLAPDPLVIPMNHETEVTFQGKNLETVKVSSLYVGSELLNFEETVTMHESDTFSFRTPKLSHDGNETLPLHLYVKSFGKNIDSKLQVTLYNCSFGRSDCSLCLAADPAYRCVWCRGQNRCVYEALCSNVTSECPPPVITRIQPETGPLGGGILVTIHGSNLGVKADDVKKITVAGQNCAFEPRGYSVSTRIVCAIEASEMPFTGGIEVDVNGKLGHSPPHVQFTYQQPQPLSVEPRQGPQAGGTTLTINGTHLDTGSKEDVRVTLNDVPCEVTKFGAQLQCVTGQQLAPGQVTLEIYYGGSRVPSPGISFTYCENPMIRAFEPLRSFVSGGRSINVTGQGFSLIQKFAMVVIAEPLRSWRRRRREAGALERVTVEGMEYVFYNDTKVVFLSPAVPEEPEAYNLTVLIRMDGHCAPLRTEAGVFEYVADPTFENFTGGVKKQVNKLIHARGTNLNKAMTLEEAEAFVGAERCIMKTLTETDLYCEPPEVQPPPKRRQKRDTAHNLPEFIVKFGSREWVLGRVEYDTRASDVPLSLILPLVMVPMVFIIVVSIYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPTLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPESRRPIVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMRTLFLELMEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGIDAIPVKVLNCDTISQVKEKIIDQVYRTQPCSCWPKPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRINTLMHYNVRDGATLILSKVGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSMKEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHDIRDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL
What is the function of this protein?
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (PubMed:17554007).  Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (PubMed:29981480).  Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (PubMed:17554007).  Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (PubMed:19948886).  Regulates the migration of cerebellar granule cells in the developing brain (PubMed:21122816).  Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (By similarity).  Plays a role in axon guidance, invasive growth and cell migration (By similarity).  May modulate the activity of RAC1 and CDC42 (PubMed:21966369).  Down-regulates macrophage migration in wound-healing assays (in vitro) (PubMed:21966369).
What are the official names of this protein?
Plexin-B2.
What is the protein family that this protein belongs to?
Belongs to the plexin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GLMU_EDWI9
Sequence: MSTSPLSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDSALTLGARQVHLVYGHGGDLLKAHLSGQPLNWVLQAQQLGTGHAMQQAAPDFSDDEDILMLYGDVPLISAATLQRLIAAKPQGGIGLLTVKLDDPSGYGRIVRHHDRVVGIVEHKDASEAQRRINEINTGILVANGVDLKRWLARLDNNNAQGEFYITDIIAMAHQEGRQIAAVHPERLSEVEGVNNRLQLSALERAYQQQQAQRLLLAGVMLTDPARFDLRGELVHGRDVVIDTNVIIEGKVTLGNRVHIGSGCVLKDCQIADDSVISPYTVIEGARLAQACTVGPFARLRPGACLDAEAHVGNFVEMKKAHLGRGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKHQTVIGDDVFVGSDSQLVAPVTVGRGATIAAGTTVTKNVGDGELVLSRVKQVQLSGWERPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_BACC4
Sequence: MRQSSQVRETKETKIKLNLQLDESTNVSIQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKEALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYCVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARVLYGSNTHHKIEALFKAFGRALREAVEKNANITGVNSTKGML
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHR_BOVIN
Sequence: MPALGSQRRLLGSLNCTPPATLPFTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAGVLATQAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALRYHSVVTLPRAWRIIAAIWVASILTSLLFITYYNHKVILLCLVGLFIAMLALMAVLYVHMLARACQHARGIARLQKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHPTCGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW
What is the function of this protein?
Receptor for MSH (alpha, beta) and ACTH (PubMed:8034052).  Does not seem to be active with gamma-MSH (PubMed:8034052).  The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:8034052).  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, BDF3, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DXS_SHEPA
Sequence: MSFDISQFPVLAQANTPDELRQLPQAVLPQLADELRGFLLKSVGKSSGHFASGLGTVELTVALHYVYNTPFDRLVWDVGHQAYPHKILTGRRERMHTIRQKGGVHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPGTLFEELGFNYIGPIDGHDVDALVETMRNMRNLSGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSTFEKPAAKPSDPTFSEVFGKWLCDIAEKDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGYKPVVAIYSTFLQRGYDQMIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRIVPNMVIMAPSDENECRQMLYTGYCYNDGPTAVRYPRGSATGAKQVETMTAMPIGKGLIKRQGKKIAILNFGTLLASSLTAAEALDATVADMRFVKPLDVELVKQLAESHDMLVTVEENAIMGGAGSGILELLQTLKLPKPVLLIGLPDEFIKHGAPDEIISELGLDATGIQKQIEDFIA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: BETI_CROS8
Sequence: MPKVGMQPIRRRQLIDATLSTINDVGINDATIAQIARRAGVSAGIISHYFKDKNGLLEATMRDITRQLRDAVAARLRPLAQASTEARLLAIVEGNFDDTQVHSAAMKAWLDFWASSMHQPQLGRLERVSSRRLFSTLAAEFRRELPREQARLAAHGLASLIDGLWLRAALSGQPFNLETARTLTTQFIRQQLAGAAPHEKEE
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.