PharMolix/UniProtQA huggingface dataset:
Protein: YCIZ_SALA4
Sequence: MSDIEAQRIAARIDTVLDILVAGDYHSAINNLEILRAELLDQVKDGISPSQAPGSPWEI
What are the official names of this protein?
UPF0509 protein YciZ.
What is the protein family that this protein belongs to?
Belongs to the UPF0509 family.
Protein: BIOF_KLEP3
Sequence: MTWQQRIERALDERQQTDAFRRRLPVSHGAGRWLEREGERWLNFSSNDYLGLSQHAGIIAAWQQGAERYGVGSGGSGHVSGYSEAHRALEEELADWLGYPRALLFISGFAANQALVAALAEKEDRIVADRLSHASLLEAASLSPAQLRRFAHNDPQQLAQLLAKPLDGLQLVVTEGIFSMDGDSAPLADIQAAARSAGALLLVDDAHGIGAIGDEGRGSCHTQAVRPELLVVTFGKAFGVSGAAVLCSESMADYLLQFARHLIYSTAMPPAQAVALSAALRVIRSDEGQQRRETLAARIRQFRAGMGDVSLGLTDSVSAIQPLIVGDNARALSLACRLREAGCWATAIRPPTVPVGSARLRLTLTAAHQAEDINRLLEALHGHGE
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: ISCU_STRP1
Sequence: MALSKLNHLYMAVVADHSKRPHHHGQLDGVEAVQLNNPTCGDVISLTVKFDEDKIEDIAFAGNGCTISTASSSMMTDAVIGKSKEEALALADIFSEMVQGQENPAQKELGEAELLAGVAKFPQRIKCSTLAWNALKEAIKRSANAQHLTDQNVKEGKNV
What is the function of this protein?
A scaffold on which IscS assembles Fe-S clusters.  Subsequently gives the nascent cluster to other proteins.  It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).
What are the official names of this protein?
Iron-sulfur cluster assembly scaffold protein IscU, Sulfur acceptor protein IscU.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
Protein: VTC2_SCHPO
Sequence: MRFSDSIEAGIYEPWRDKYMNYPELKHLLKTEEEAPSWGENDESKFVSVMDAQLEKVYAFHLEILKELNESVDWVKSKVSASQEPDGPPISKEEAIKLLERLDSCTETVKKLEKYTRLNLTGFFKIVKKHDKLYPGYSLRPVFQVRLRACPLGSVQFNPLLAEIFSLYNTLRDGLSAPSNSVQVKPKHEHNVDYNSSMYRRRTFRFWVHPDNVMEVKTYIMRHLPVLYYSGKQGFDKDQNGVSGILDPISTCLYLDNSNFDLYSQNLERSEQAYSLRLHWYGKLTPKTDIIVERMVRQGSTLSHSEDRFTIREKKVRELLSGRYDFRKVEDDHSTTASDQKKKLIEDVEQLIVDNHLQPVLRSVYTRTAFQIPGDDEVRINLDSDWVMIREDSLDIERPCRDPEDWHRHDIDDADFPYKHLRKGEYSRFPYSVLEIRECVRYDEDEPLWISELRNSHLISEIDGFSKYEHGVAILFEKYVSLLPMWVFSMDQDIRKDLQEVYSHPEGSAGSRNVYIKRRNQRVLKQNMTPEPSQPSPLVNRLKANEMHPVSEEPEDNREVYRNEHGDHFNFRSIPGLLKPSTYGSFKHHGKTFVTPPHIKKPEIPLRVSGPIKVEAKVWLANERTFLKWLHVVVLLGSLALALYNSAGERLGQAFGVVYTLLAIFIGFYAWKLHAKRSQMIKSRSPAPMTDYWGPLIVGTALAISLIVNMSFALKDAVYQNLIEPDRLLVKLFT
What is the function of this protein?
Accessory subunit of the vacuolar transporter chaperone (VTC) complex.  The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP.  VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation.  The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen.  PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase.  The VTC complex also plays a role in vacuolar membrane fusion.
What are the official names of this protein?
Vacuolar transporter chaperone complex subunit 2, SPX-dependent polyphosphate polymerase VTC subunit 2, Vacuolar membrane polyphosphate polymerase accessory subunit 2, PolyP polymerase.
What is the protein family that this protein belongs to?
Belongs to the VTC2/3 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: LIPA_VIBCH
Sequence: MSKPIQMERGVKYRDADKMALIPIKNMPTEQKEVLRKPEWMKIKLPADSQRIQDIKAAMRKNNLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPNAPEAEEPKKLAQTIHDMKLKYVVITSVDRDDLRDGGAQHFADCNREIRALNPHIKIETLVPDFRGRMEVALEALKDNPPDVFNHNLETAPRLYRKVRPGANYKWSLELLRQFKEQHPHVPTKSGLMMGLGETKEEIVEVLKDLRAHGVTMLTLGQYLAPSRHHLPVERYVPPAEFDELKEVALELGFTHAACGPFVRSSYHADLQAKGLEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLR39_PLAVT
Sequence: MRGAYYVAIALLIVASCSAAEVDQTEPEKVPNNGFVTSGGTVNKMLPKRVLRGSRDLKNKWAVHAGGEDRMLNRFSNENNLLEGIDQTITKAANVMGTNRDDVIVKAAEAMTNYKQLDPTLNILNSKHQLIKPRPINVYRQALLHATPNPKKSVVAVPNDVPFVLANRLEREKSTNTVNYAGRPITQHDYLPASLSFPSTSAVAPDGQFNKQLITQKALEFDLIKRPDEVKARSSKRQRTNPMLNNMDGRELHAQPNLEEPLAPVANNMPFVWATKLGEK
What is the function of this protein?
Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins.
What are the official names of this protein?
Secreted RxLR effector protein 39.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: MEND_PROMS
Sequence: MTSSIECKNFLRSLQLLNLLIKIGVKNLILCPGSRSAPLAIAAGELNKLGLVNIFNSIDERSAGFHSLGISAASGHLSLVITTSGTAVSNLLPAAVEADRSCKGIIFLTADRPLRLKDCGANQTVNQEDFLSSVCRKVLSTNLNGIHETEENEIFNLVRISEKQMSTFPGPIHLNVPIDKPLDISFLNKKNVLEVFERIYLKKKYVFQEVDIKSDKKKFLEISKNLNLDESGIILVGPYQGSINDLPSFNKSLGQLQEITGWPVFADPVSGVYSDLRGLIVNWELVLRKNKNLINCYQLLRLGPMSSSNDLEKFLINFQGVQILIKEKNHRKLDPIKKSFEYDFGLTNFTSLLKKELSINEKNKKSLTPLALDLLEEGKQVKEILKGNITYENQITEYRLANLVPKLWPAENPIMLSASSPIRDWLTFSENGTLTRNCFSFRGASGIDGTLSLALGISRIKNPLLLVTGDLAFLHDINGWLIENSIDMNLTILLINNNGGNIFNRIYKKNLKEDEFKKLFLMPKEINWPKLAEGYQVNFRSVANFKKLREAFDWSISIEKSAIIKVDIDPQNEICEKNSLLEKIIGS
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: AROC_ANADF
Sequence: MTIRYLTAGESHGPGLVAIAEGFPAGLAVDFDEVNRDLRRRQKGYGRGGRQKIEKDEAEFLAGLRGGVTLGAPIALVVWNKDHESWKDLVSPYARGGRPFTQVRPGHADLAGALKYALTDARDVLERASARSTAVTVALGSLAKQLLARFGVRVSSRVVAIGPRLRHVEEPPTDAERDAIEASDLHVEDEAVAAEWRALIDAEKARGGSIGGAFDVHATGLPIGLGSHVHPDRRLDARLAGALCGVQAIRAAEIGDGTQVGRSGPEFHDAIQHDPARGFHRPSNRAGGLEGGMTDGMPLRVRAYMKPIPTMLTPLATVDLATREATQARYERSDVCAVPAAAIVGEAVVAWELANAFLEKFGGDALVDVEKAVEAYAARIR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: UP02_CAPCH
Sequence: LAGTVPLANK
What are the official names of this protein?
Unknown protein 2.
Protein: HEMH_PSYCK
Sequence: MKPDLPPRIAVLLVNLGTPDEPTAPAVRRYLKQFLSDPRVIEIPKFLWAIILNLFVLPSRPKRVAEAYASIWDGDSPMRNILNAQVEMLDKRLADRAAPFRVSVHAAMSYGNPGLPDVMDQLRSEGVDHFVMLPVFPQYSATSTGAVYDAITKWSLKQRNLPNITIVKDYFAHPLYIKALADSIRRFQAVHGKPEKLMFSFHGIPQPYADKGDPYPKRCKCTAAQVAHELGLKPDEWIISFQSRFGKQEWIKPYTDVVLKEWGSSGVRSVQILSPAFSADCLETLEELAIENRETFLHAGGQEYHYIPALNADEAHIDLLEAMSAPLVKGWAGTLDGWA
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AFFL_DROAN
Sequence: MAQQQQQQHNHQTSNNNNNNSSILLLQQQQLHQEQLQQYNNNLYSQNYNMEEYERRKRREREKIERQQGIQIDDRETSLFGEPRRLTEADADITAALGEFGDARVYINQSTVGISRHTPGAGNPRLQAPLQPPPKSLGHSPSYTGSTGSASASANSAVPSQQQQQQHYNGTGGRFLPPAASKRSSSGAGQQPLPQEKDISKMISEMADNFRVTPLTSIAATPHAPVRENYNLNGPNKNKYMDDIISSPLSQPSSLMTPLFAPIAPIASPPQTSQLPLGGATSLTGSSEAVLGLAPLQQLPPTPPKAASAITSPAAAKPLKTEKNHTLEKQDSCLENDLELSESEDEQPKKEGRSAGNSSNSSESDSSESGSESSSKNDAQPLPNHKLHHQQQQQLQQQPLQQQQHQQQQQQQILLQQQQQQRPQQLTANGKSEKKKYKHAIIAGGSNTITGLLTSSGFGSGGNGGPGGNSCGPGSGASASAGTMSSGGSSSNKTPSPTESNKWTLSRFFPKPANQTNTESATPGNVSMKVPGILPGGAQIIPEPIEVSTAIVKNEKIHDDPMDMDDGEEDDDDEDQQQQQQQQLHYRADLSVTPVSVKKEAIDGVSELGLAAIPKNQIKRESSEALHASRLSDSGTSGSSSSSSSSSESAPGGEVVPMPGPGETLQIPGGAAITSVMRVPPTLTQKAPSSTSVTLMPILPLPMSPKQRQKKQRKKKTSTPIVNSSDEDEPAPKHPGLDYTAVSAHSQSTATAPAKKRGRPRKQQQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPLCKALPAMGGARKRDHSSQSSSNGNTPTKKMATPMSVSAPPKTASVHRDSSSSDDDSSSSGGSSSKSSSSSSSSDDTEEAQNTNCRIVKLNKTGAGAVAAKVLLGSGSSSALSSGSEAEDQARSQAGSGKALAQQMPPYKPQVMSQHSQQLSSSECSSSSGDRGGTGAGSSSSGEEDEARHEKERERKPKSDKNKISTLTRIFNPKEGGAKKQGQVVIMDLQEEQQQGKLDAATQSSQIPATAPAVKPRMTPTQQLQQQHAQSQQMLGTSLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKGQAASAVQMPNGYANDAVPAAKVKPEHPVKPEPDADYEAKFKPGSVKQEFQLKQERDRDRERERERDREQPPGRRRKRSSSSSSSPYKEKKRKKEKTDQLQICKELLPSNNHERIPNHDRLSYDKLQLLHEDAAAAAAASGVGAAPNGSPRKNLLAMSPLPPPPISTAIAIVPPITCNEAVQTTPPLTTSTSPQAASAVTEPAPPAVAVPPAPVTRLIYRSYFDREEAHPSADLRRNNQFLQEAVNRKHAADAEPDSFNQVTLYLEAVVYFLLTADAMERCSSEATYTMYKDTLSLIKFISFKFRPQHSANGQTKTHMAKVAILSLRCQSLISLKLYNLRRANCRDIIASLTDFFRTGRGDIVNGNTPSSISPSNSVGSQGSGSNTPPGRIVPRDIHNQLSKQNEYLSYVHSAHELWDQADHSVRKGNHTDFFRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSHTAHPTQ
What is the function of this protein?
Has a role in transcriptional regulation.  Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth.  Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate.  Required specifically for the microtubule-based basal transport of lipid droplets.  Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye.  Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).
What are the official names of this protein?
AF4/FMR2 family member lilli, Protein lilliputian.
What is the protein family that this protein belongs to?
Belongs to the AF4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH602_ANADF
Sequence: MASKEIIFDQKARDAILKGVNTLADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIELENKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQALYREGSKLVAAGHNPMEIKRGIDKAVEIIVGELKKLSKPTKDQKEIAQVGIISANGDETIGNIIAEAMEKVGKEGVITVEEAKGLETTLEVVEGMQFDRGYLSPYFVTDAERMVANLEDAYILIHEKKISNMKDLLPLLEQIARSGKPLLIVAEEVEGEALATLVVNKLRGTLHVAAVKAPGFGDRRKAMLEDIAILTGGRMIAEELGLKLEQVSLKDLGRAKRISIDKDNTTIVDGAGQKADIEARVKTIRAQIEETTSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVAYLRAVKALEGVKVSEGEKFGLDIVRRALEEPLRQIAGNGGYEASIVVNKVKESKDTNFGFNAATGDYEDLVKSGVIDPTKVSRSALQNASSVASLMLTTMALVAEKPKEESAAPAGGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_FRACC
Sequence: MKVVDPDIGTGGSTVITASETRTLRVSTAPHLAPGADPTMIRNFCIIAHIDHGKSTLADRMLGVTGVVEARNMRAQYLDRMDIERERGITIKAQNVRLPWRADDGRDYILHLIDTPGHVDFSYEVSRSLAACEGAVLLVDAAQGIEAQTLANLYLAIENDLTIVPVLNKIDLPAAQPEKYAEEIAAIIGCEPGEVLRVSGKTGQGVPELLNEIVRRVPAPVGDPDGPARAMIFDSVYDIYRGVITYVRVVDGTLTTRDRCLMMSTSASHETLEVGVISPDPHPTGSLSVGEVGYVIPGVKDVRQARVGDTITTTRRPATEMLGGYRDPLPMVYSGLYPIDGSEYPALREALDKLQLNDAALTYEPETSAALGFGFRCGFLGLLHLEIVRERLEREFNLTLISTAPNVVYRVVMEDHSEIIVTNPSDWPGGKIAEVYEPVVEAMLLLPTDFVGAVMELCQGRRGVLKGMDYLSTDRVELKYTLPLGEIIFDFFDALKSRTRGYASLDYEPAGEQLADLVKVDILLQGETVDAFSAIVHREKAYAYGVSMTTKLRELIPRQQFEVPIQAAIGSRIIARENIRAIRKDVLAKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFIAALSTDTGKPAVK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AROQ_AZOC5
Sequence: MSDTIHVLNGPNLNLLGTREPGIYGAATLADVEALCRTTAAQHGLELVFRQSNHEGDLVDWIQAAAGSVGVVLNAGAYTHTSVALRDAIAGTGVPAVEVHLSNVFAREPFRHHSYLSPVVRGVICGFGPQSYVLGITALATTRPARP
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: ELMD3_BOVIN
Sequence: MNENFHSFHEKELRDGQVESVSAGSSPPCDKDSSALLAFRGISISELKNHSVLQALTAEANAWEPRVVSTEVLQAQEEWEAVESIHPETGSRASMDQPGQLISFSEALQHFQTVDLSSFKKRIQPTIRRTGLAALRHYLFGPPKLHQGLREERDLVLTIAQCGLDSQDPMHGRVLQTIYKKLTGSKFDCALHGDHWEDLGFQGTNPATDLRGAGFLALLHLLYLVMDSKTLLMAREILRLSRHHIQQFPFCLMSVNITRIAIQALREECLSRECNRQQKVIPVVNSFYAATFLRLAHIWRTQHKTISDSGFVLKDLEMSAKKSPRRLLKTLETYLAGVSKGQASLLGTQKCSGPQAPHSKDLTFTGVCDLPSHLSEGTWLI
What is the function of this protein?
Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity.
What are the official names of this protein?
ELMO domain-containing protein 3, RNA-binding motif and ELMO domain-containing protein 1.
What are the subcellular locations of this protein?
Cell projection, stereocilium. Cell projection, kinocilium. Cytoplasm, cytoskeleton. Note=Also present in the cuticular plate of auditory hair cells. Expressed along the length of the stereocilia, but excluded from the very tip. Colocalizes with F-actin cytoskeleton (By similarity).
Protein: FGFR4_XENLA
Sequence: MSGSIRRSYTAMQNFPRFLLGVLFVATLSSCRPRLSEDEANWKGQTETSEVEEHLLLDPGNALRLFCDTNQSSSINWYREQERLLSGGKIRMVGTVLEVSDVTYEDSGLYICVVRGTGKILRRFSISVVDSLASGDEEEEEEDDDDEDGRREDTTADINEEPVYFFQAPYWTQPSRMDKKLHAVPAGNTVKFRCPAGGSPLPTIRWSLKNGREFRGEHRIGGIQIRHQHWSLVMESVVPSDRGNYTCVVENRVGSLTYTYFLDVLERSSHRPILQAGLPANTTARVGSDVEFYCKVYSDAQPHIQWLKHIEVNGSHFGPDDFPYVQVLKTADINPSDVEVLHLRNITMEDAGEYTCLAGNSIGLSHQSAWLTVLPNEDFLEQAEPAESRYMDIIIYTSGFLAVAMAIMIVILCRMQTPHSKQTLQTPTVHKLAKFPLIRQFSLESSSSGKSSAPLIRITRLSSSCAPMLPGVMEVELPLDAKWEFPRDRLVLGKPLGEGCFGQVVRAEGYGIEKDRPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPVIPYEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPTQRPTFKQLEHLDRILTAVSEEYLDLSMPFEQYSPSCEDSASTCSSSDDSVFAPDPVPSSPCVFNYHNIHSQLGT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.  Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.  Phosphorylates PLCG1 and FRS2.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 4, FGFR-4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
Protein: NITR_PARP8
Sequence: MSDQRVIRAAAVQIAPDFERPGGTLDRVCAAIDEAASKGVQLIVFPETFVPYYPYFSFVRPPVASGADHMRLYEQAVVVPGPVTHAVSERARRHAMVVVLGVNERDHGSLYNTQLVFDIDGCQVLKRRKITPTFHERMIWGQGDAAGLKVARTGIARVGALACWEHYNPLARYALMTQHEEIHCSQFPGSLVGPIFAEQIEVTIRHHALESGCFVVNSTGWLSDAQIESVTTDPKLQKALRGGCMTAIVSPEGQHLAEPLREGEGMVVADLDMALITKRKRMMDSVGHYARPELLSLAINDRPAMPVVPMSMSFERAGADVAPEIISGGQDECQHEPVAG
What is the function of this protein?
Catalyzes the hydrolysis of a broad range of nitriles to yield their corresponding carboxylic acid and ammonia (Ref. 2, PubMed:34277586, PubMed:34270173).  In vitro, shows high activity toward benzylic/unsaturated nitriles (PubMed:34277586).  The preferred substrate is trans-cinnamonitrile, followed by mono/di-cyanopyridines and aromatic substituted nitriles, with a moderate activity toward 3-phenylpropionitrile (PubMed:34277586).  Shows weaker activity toward the common dinitrile fumaronitrile (PubMed:34277586).  Also shows weak activity toward some aliphatic nitriles, including adiponitrile and glutaronitrile, and the arylacetonitrile 2-thiopheneacetonitrile (PubMed:34277586).
What are the official names of this protein?
Nitrilase, NIT188, Nitphym.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: APOA1_PANTA
Sequence: MKAVVLTLAVLFLTGSQARHFWQQDDPQSPWDRVKDLVTVYVDAVKDGGREYVAQFEASALGKQLNLKLLDNWDTLGSTITKLREQIGPVTQEFWDNLEKETEVLRQEMSKDLEEVKQKVQPYLDDFQKKWQEEVELYRQKVAPLGTELRE
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility (By similarity).
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: END4_FINM2
Sequence: MNRIGCHLSTSKGLHKTIEQCLEINADTFQFFPRNPRGSKSRLIPKKEIDKFLELRKIHNINKIVCHGAYTMNLCSDREDLRKLAVKLINEDMKKIQDMRINHYVLHPGSHKNQGIEEGLKLIVEGINKVDVSNGQMICIETMSGKGSELGCDIDQIAYIINNASIPLYVCIDTCHLFSSGIRLDNFDDYLDEFDKKIGIDKIKVIHCNDSMMPFGANKDRHEKFGKGLIGEQDLFNVIFNERLKDRPIILETPNDLDGYKIEIEEIRRNFNELRQN
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: IRAD_ECOSM
Sequence: MMRQSLQAVLPEISGNKTSSLRKSVCSDLLTLFNSPHSALPSLLVSGMPEWQLHNQSDKHLQSWYCRQLRSALLFHEPRIAALQVNLKEAYCHTLAISLEIMLYHDDEPLTFDLVWQKGSWHRTMPQ
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraD.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family. IraD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_DESVV
Sequence: MENKRAIIAVVLSFIVLVGWGYLSEYMGWTPKSVPATEQKTAASAPAPSVVTSAPEAVTPAPAFSPSTGHEVTVTTPLYKAVLHSGGGVLRQFMLSRYHMGIDRDAAPVNLIESSAIRVAPLGLLVNGQPSWNTGQWAFEGGDLNLADGQTGTLRFVGSVDGLRVVRELEFHADSYLVTEKLHLAPEGDAPRTARVGFTLGTTSLTPGESQYNLTRVAWFADGSFSEKSSTGDLEKGVLIDGSIDWAGVMSNYFLAAVAPKDTRAVLKGKLEGGVYRVAVERPDQMVNPGNSDVIVCNYWFGPKERDLLNAAPNNLGKAIDLGWFGFIARPLVTLLDFFYKYVGNYGTAIILLTILIKLVFWPLSHKSYKSMEQMKKLQPMLAKVREKHADDREKMNEEMMRLYKTYKVNPAGGCLPMLVQIPVFFGLYQALLNAIELRHAPFIAHVPFTDIVWLADLSAKDPFYVTPLVMGATMFLQQKLTPPAGDPTQAKVMMFMPVVFTFLFLNFPSGLVVYWLCNNVLSIAQQWWILRKA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CH10_STRCV
Sequence: MLKPLGDRVVLKVEEREQKVGGFVIAGAGQDATKTAKVIAVGEGIRTLNGELVAPSVKADDTVLVESHAGIEVKDGEEKYLVVNETNILAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQEN_BACSU
Sequence: MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQETKDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSALESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKRNEKNDPHY
What are the official names of this protein?
Uncharacterized protein YqeN.