PharMolix/UniProtQA huggingface dataset:
Protein: PCSK9_HUMAN
Sequence: MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
What is the function of this protein?
Crucial player in the regulation of plasma cholesterol homeostasis.  Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658).  Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway.  May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.  Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827).  Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner.  Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751).  Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation.  Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 9, Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.
Protein: LEUC_SORC5
Sequence: MGKSLYDKVWDLHKVRTLPSGEDQLFIGLHLIHEVTSPQAFGMLRDLGLRVSMPERTFATLDHIVPTDNRKRPFKDTLAEGMVDALKKACTEQGVTFFDLESGKQGIVHIIGPELGLTQPGMTIACGDSHTSTHGAFGAIAFGIGTTQVRDVLATQTLSLQRLKVRRIQVEGKLGPGVYAKDIILEIIRRLGVSGGTGYAYEYGGSTIEGFSMEERMTLCNMSIEGGARVGYVNPDQVTFEYMKGRPYAPKGEAWEKALEYWRSIASDEDARYDDVVRINASEIAPTVTWGITPGQAISVKEKVPAAEDVTNESERALIREALEYMRLEGGKPIEGTKINVAFIGSCTNGRLSDFREVARRIQGHRVAPHVRALAVPGSMEVARAAEAEGLDRVFREAGFEWREPGCSMCLAMNPDKLIGDELCASSSNRNFKGRQGSPTGRTVLMSPVMVAAAAVRGEIADARDVFGI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: Y594_BACC7
Sequence: MSIKYSNKINKIRTFALSLVFIGLFIAYLGVFFRENIIIMTTFMMVGFLAVIASTVVYFWIGMLSTKTVQIICPSCDKPTKMLGRVDACMHCNQPLTMDRNLEGKEFDEKYNKKSYKS
What are the official names of this protein?
UPF0295 protein BCAH187_A0594.
What is the protein family that this protein belongs to?
Belongs to the UPF0295 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHLB_VIBPA
Sequence: MKKTHITEQKFADLGLQPQVTEGLEKKGFEYCTPIQALALPVLLTGQDIAGQAQTGTGKTLAFLTATFNHLLTTPEHEGRQPTQPRAIIMAPTRELAIQIFNDAEPLIASTGLKAALAYGGESYDKQLAKLQDGVDILIGTTGRIIDFYKQRVFNLNNIQAVVLDEADRMFDLGFIKDIRFLFRRMPEPKERLNMLFSATLSYRVQELAFEHMHNPEHVVVEPAQKTGHRIQEELFYPSNEDKMALLQTLIEEEWPDRAIVFANTKHKCESVWGHLAADGHRVGLLTGDVPQKKREKILEQFTKGDVDILVATDVAARGLHIPQVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISFACEEYAINLPAIEEYIEHTIPVSEYDASALIQDLPAPIRMRAPRVQQRRTNTGGTRSGNRKPQGRRPRQPRQSAPKQS
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_SYNY3
Sequence: MERTFIMIKPDGVQRQLIGEIVGRFEKKGFKLVAMKVMTVSQELAEKHYEALNDKPFFSGLVNFICSSPVVAMVWEGNSIVSTSRQMIGATDPHAAAPGTIRGDYGVSVGRNIIHGSDAIETAKREISLWFKDEEVNEWDATLNPWLYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAC3C_ARATH
Sequence: MNRRNRGSSSSSSRVSNTYGNRQFSDNPRTGSGGGVNESFQRRSDAPHKRNNEKDESKHKDEDPADVSLIVGTCSSMCPERERVTRERLRDLAVFERLYGNPSKSSTEIAVKKFCRTLSAADVQASDVRPLPVLEETLRYLLSLLDSKEHPFEVVHDFIFDRTRSIRQDLSIQNLANERVIYLYEEMVKFHVISHERLQSCSGTSISSMHHLNMEQLAKTLTSLYNIYDANRKPDYIYENEAEFRSLYVLLHLNPSSGVMGEPLSLWFRKLTFALVKSKEICFVRNLLRLYRMGNYKNFLSRTASEATYLQYCISEHHIREMRLVAVQYINNVCYKLQPYPLLRLSQNLKMKELDVESLCHECGLETCTDPDGFTVLPVKQSTFRSPEDKFKVYDLIGIERIKMSI
What is the function of this protein?
Possible component of the TREX-2 complex (transcription and export complex 2), a muliprotein complex that functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
What are the official names of this protein?
SAC3 family protein C.
What is the protein family that this protein belongs to?
Belongs to the SAC3 family.
Protein: FTSI_BUCBP
Sequence: MKYFFQNKKNIHIKNETFNNRITILLSLIIITIILVLSRITFLQIIVSKKLIYKSNLRSLRTQIEFNQRGNITDRLGYPLAINIPVKNICIDPKLLFSKQTHIYPNLKWKMLSTVLSIPLSEIFYRIKYSKNNHFIYLAHKVNPEISEYISQLHIPGIYILDDFKRFYPFGKLTSQLIGFTNIDNEGIEGVEKSFNKLLMGKPGKKQIITDRYGRIIEQHNLVNKIQSHDIILSIDCSFQKFIYHILNQAVMSNKAKFGVAILVNIPTGEILSMVNTPSYDPNNSSELFKNNPLIRNKAITDIFELGSTVKPMIIMKALEKKIITPETVINTSSLVVNKHIIHDVSYHHALTASDILKKSSNTGVSRLALSIPISELIDIYSKFELGKSTNLGLIGERNGVLNTNKKHWSDLDKVTLSFGYGLMATPLQLARIYTTIGRYGLSKPLSIIVKNDTNLKNDIFSKQVFSKKIIKTVINMLEEVAKPGGAGFKAAIKGYRIAVKTGTAKKINSKGKYDNKYVSYIVGFAPVSNPTFCLMIMINEPKSNKYYGGEIAAPIFKTIMQKILKIKNIKPDAYL
What is the function of this protein?
Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
What are the official names of this protein?
Peptidoglycan D,D-transpeptidase FtsI, Penicillin-binding protein 3, PBP-3.
What is the protein family that this protein belongs to?
Belongs to the transpeptidase family. FtsI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CHM2B_MOUSE
Sequence: MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis.  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 2b, Chromatin-modifying protein 2b, CHMP2b.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein.
Protein: EX7L_BARHE
Sequence: MNLFFEKTGATNVAEFSVSEIAGALKRVVEEKFGYVRVRGEISGYRGAHASGHAYFALKDDKARLEAVIWRGIMEKLKFPPEEGMEVIAVGKLTTYPGSSKYQIVIEALEPTGVGALMTLLENRKKKFAEEGLFDEEKKKPLPYMPKIIGVVTSPTGAVIRDIIHRISDRFPLHILVWPVRVQGETSGREVAAAVKGFNVLPLEGLIPKPDLLIVARGGGSLEDLWGFNDEVVVRAVYESSLPVISAVGHETDWTLIDYVADWRAPTPTAAAEKAVPVKIDLEVYVVSLGARLRTGLARYFDFHQQKLRAIIRALPTADQLFALPRRGFDEISSRLERALCVSCDKKRLYFHTLAIRFTPRLLNTEKAQHSAKEYTARLHRAFVHIVEKQRAQLEIAFRLLKSTSYQNILERGFVLALGQNNKPIKRLAQIPEKEQINLRFFDGEISVITQESFFNRSSKSKRIKSKQDDQGTLF
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FZD7_CHICK
Sequence: MRPAAGEAGAGLRWLGLAALLAALLGTPCAAAHHEDKAISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAPPGPGGAGGRGATAQPTAGYLPDLLTPPQPAAGFSFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRPNGLMYFKEAEVRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYAAGFLLEERVVCLERFSEDGYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDVLSGVCYVGIYSVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVVACYFYEQAFRSTWEKTWLLQTCKTYAVPCPSHFAPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSTGSKGETAV
What is the function of this protein?
Receptor for Wnt proteins.  Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
What are the official names of this protein?
Frizzled-7, Fz-7, cFz-7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions.
Protein: METE_HAEIG
Sequence: MTTSHILGFPRVGAKRELKFAQERYWRKELAEQDLLDLAKALREKNWKHQAAANADFVAVGDFTFYDHILDLQVATGAIPARFGFDSQNLTLDQYFQLARGNKDQFAIEMTKWFDTNYHYLVPEFQKSTAFKANPAHYVNQIREAKALGLNFKPVIVGPLTFLWLGKEKGEAFNRFDLLNQLVPVYVEILNALVAEGAEWIQIDEPALALDLPAEWVEAYKSVYAELSKVNAKLLLATYFGSVAEHAELLKALPVAGLHLDLVRAPEQLAAFEDYSKVLSAGVIEGRNIWRANLNKVLDVLEPLKAKLGERLWIAPSCSLLHTPFDLEVEVQLKEKNTALYSWLSFTLQKVEELNVLKQALNNGRASVQAALDASQAAADARATSKEIHRPEVAERLANLPKGADQRKSPFAERIVKQNAWLNLPLLPTTNIGSFPQTTEIRHARASFKKGELSLADYEAAMKKEIEYVVRRQEELDLDVLVHGEAERNDMVEYFGELLDGFAFTKFGWVQSYGSRCVKPPVIYGDVIRPEPMTVRWSQYAQSLTNRVMKGMLTGPVTILQWSFVRNDIPRSTVCKQIGVALSDEVLDLEAAGIKVIQIDEPAIREGLPLKRADWDAYLQWAGEAFRLSSMGVQDDTQIHTHMCYSEFNDILPAIAALDADVITIETSRSDMELLTAFADFKYPNDIGPGVYDIHSPRVPTATEVEHLLRKALNVIPKERLWVNPDCGLKTRGWTETIDQLKVMVDVTKKLRAELA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: MNMA_COXBR
Sequence: MPNFEQNQVIAVGLSGGVDSSVAALVLKEKGYEVIGLFMQNWETDSKDPFCTAEQDLSDAKAIADHIGIPLYVVNFSKAYWNHVFQHCLDEFAQGRTPNPDVWCNREIKFKSLLDHAKKLGATHLATGHYACIQNENNEYRLLKSNDSHKDQSYFLHLLNQYQLANSVFPIGGYQKSEVRAIAKKRGFINHAKKDSTGICFIGERKFKDFLNEFLLAKPGNIETSEGKIIGKHDGIMFYTVGQRKGLHIGGRPDAGEAPWYVVDKDVKRNVLIVVQGYEHPLLYSQELTCTNLHWIRDTEPSFPLTCKAKTRCRQADQTCVVTRLDNDHCHVQFEHPQRAITRGQSVVFYLGNECLGGGIIN
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_AQUAE
Sequence: MRVAVGMSGGVDSSVTALLLKEQGHDVIRVTLRFHTVEACEVNETHNVCCSPKDVQDASRVAKRLGIPHLVFSWEEIFKSKVIDYFVEEYKRGRTPNPCALCNREVKTGFFARYLKQVADIDKLATGHYAKIEEDKKYGLVIKRPKDRKRDQTYFLSLVRREDLELLTFPLGAYTKEEVREIAKRYGLEVAQKRDSQEVCFLMGKSPGEYLEGILGKQRGLIKHVSGKVLGEHEGVYRYTIGQRRGLGISYGKPVYVIDIDAKTNTLIVGEEEYLYNDKLLVKEINFHVPLEKWENVSAQIRYRHKPVPVERIEKTEEGFLVKFKEDVRGITPGQVVAFYDGDVLLGGGIIEESVK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_THET2
Sequence: MAKGEFIRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGEIDKAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLNQYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWELLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGVLLRGVSREEVERGQVLAKPGSITPHTKFEASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTGVVQLPPGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNRG_MOUSE
Sequence: MNLEPPKGEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII
What is the function of this protein?
Participates in processes of transmission and amplification of the visual signal.  cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
What are the official names of this protein?
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, GMP-PDE gamma.
What is the protein family that this protein belongs to?
Belongs to the rod/cone cGMP-PDE gamma subunit family.
Protein: GYRA_HELPY
Sequence: MQDNSVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGKYHPHGDNAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAVGMATSIPPHRMDEIIDALVHVLENPNAGLDEILEFVKGPDFPTGGIIYGKAGIIEAYKTGRGRVKVRAKVHVEKTKNKEIIVLDEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLHLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIKTSQSPEAAKNALMERFTLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEDRLNGVVKTELLEVKEQFSSPRRTEIQESYENIDIEDLIANEPMVVSMSYKGYVKRVDLKAYEKQNRGGKGKLSGSTYEDDFIENFFVANTHDILLFITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPDEKIMATLSTKDFSDERSLAFFTKNGVVKRTNLSEFESNRSCGIRAIVLDEGDELVSAKVVDKNAKHLLIASHLGIFIKFPLEEVREIGRTTRGVIGIKLNENDFVVGAVVISDDGNKLLSVSENGLGKQTLAEAYRGQSRGGKGVIGMKLTQKTGNLVGVISVDDENLDLMILTASAKMIRVSIKDIRETGRNASGVKLINTADKVMYVNSCPKEEEPENLETSSAQNLFE
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_RHOPT
Sequence: MAVPRRKTSPSRRGMRRSADAIKRPTYVEDKDSGELRRPHHLDLKTGMYKGRQVLKKKDS
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: MDH_RHIE6
Sequence: MARNKIALIGSGMIGGTLAHLAGLKELGDIVLFDIADGIPQGKGLDIAQSSPVEGFDANLTGASDYSAIEGADVCIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIKKYAPNAFVICITNPLDAMVWALQKFSGLPANKVVGMAGVLDSSRFRLFLAKEFNVSVQDVTAFVLGGHGDTMVPLARYSTVGGIPLTDLVTMGWVTKERLEEIIQRTRDGGAEIVGLLKTGSAYYAPAASAIEMAESYLKDKKRVLPCAAHLTGQYGVKDMYVGVPTVIGAGGVERVIEIDLNKTEKEAFDKSVAAVAGLCEACINIAPALK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: GBRR1_MOUSE
Sequence: MLAVQNMKFGIFLLWWGWVLAAESTAHWPGREVHEPSRKGSRPQRQRRGAHDDAHKQGSPILRRSSDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSSNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKISCTCGLPQPRGVMLDSSYSDGEVNDLGGYMPENGEKPDRMMVQLTLASERGSPQRKGQRGSYVSMRINTHAIDKYSRIIFPAAYILFNLIYWSIFS
What is the function of this protein?
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.  Rho-1 GABA receptor could play a role in retinal neurotransmission (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit rho-1, GABA(A) receptor subunit rho-1, GABA(C) receptor.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: DLX4_MOUSE
Sequence: MTSLPCPLPDRGASNVVFPDLAPALSVVAAYPLGLSPGTAASPDLSYSQSYGHPRSYSHPGPATPGDSYLPRQQQLVAPSQPFHRPAEHPQELEAESEKLALSLVPSQQQSLTRKLRKPRTIYSSLQLQHLNQRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKKLLKQSSGEPEEDFSGRPPSLSPHSPALPFIWGLPKADTLPSSGYDNSHFGAWYQHRSPDVLALPQMM
What is the function of this protein?
May play a role in determining the production of hemoglobin S.  May act as a repressor.  During embryonic development, plays a role in palatogenesis.
What are the official names of this protein?
Homeobox protein DLX-4, Homeobox protein DLX-7.
What is the protein family that this protein belongs to?
Belongs to the distal-less homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS1_ACAM1
Sequence: MLTVALPKGALLKDSIRLLQSVGLDFSAFLDSGNRQLQIQDPTQTAQGLLVRAQDVPVYVEYGQAQLGIVGFDVLQEKKPQVAQFADLGFGHCRMSVAVPSQSPYRSAMELPPNCRVASKFVHCAHDFFSKIDLPVEIIPLYGSVELGPITGMSEAIVDLVSTGRTLKENGLIELDCLYDSTARLIAHPLSYRLNQYNLEHWLNEISKNSQPLAAKAS
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V13K_TRVPL
Sequence: MKALFLVTRRVVSVMLTSCESKLPTWLVSHVGVRKIIVDGLSVLLLTILLLMCIIVVAVVTLKSVVNVLKRGIEKSGNRLNEFELKDRLLRLKSPEIRNPLRRNSKREKSLGHQKDF
What are the official names of this protein?
16 kDa protein.
Protein: URE3_MYCBT
Sequence: MRLTPHEQERLLLSYAAELARRRRARGLRLNHPEAIAVIADHILEGARDGRTVAELMASGREVLGRDDVMEGVPEMLAEVQVEATFPDGTKLVTVHQPIA
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRRA_STAAU
Sequence: MSNEILIVDDEDRIRRLLKMYLERESFEIHEASNGQEAYELAMENNYACILLDLMLPEMDGIQVATKLREHKQTPIIMLTAKGEETNRVEGFESGADDYIVKPFSPREVVLRVKALLRRTQSTTVEQSEPHARDVIEFKHLEIDNDAHRVLADNQEVNLTPKEYELLIYLAKTPNKVFDREQLLKEVWHYEFYGDLRTVDTHVKRLREKLNRVSSEAAHMIQTVWGVGYKFEVKSNDEPAK
What is the function of this protein?
Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation.  Also plays an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate (By similarity).  Functions as a transcription regulator by direct binding to promoter regions of target genes including agr, spa and tst promoters (PubMed:11157922).
What are the official names of this protein?
Transcriptional regulatory protein SrrA, Staphylococcal respiratory response protein A.
What are the subcellular locations of this protein?
Cytoplasm.