PharMolix/UniProtQA huggingface dataset:
Protein: SYN_MYCGE
Sequence: MKSVTVKQLLQTPRKFNNKQIKLSGWVKNKRASANIIFLAISDGSSINTLQAVVKQEDNPQVFSLLQTVNLASAVMVWGEIILTPKAKQPLELKLKQVSLLAQAESDYPLQKKEHSQEFFRSNAHLRVRAKTYFAVMKIRSVLSHAIFEYFFKNDFILVQSPILTSNDCEGAGETFVIKDSETFFNKTTFLTVSGQFGAEAFAQAFKKVFTFGPTFRAEKSHTNRHLSEFWMIEPEIAFANLKDLMQLIQNLIKFLIKKVMENASDELNVLAKQFSNDIISNLKTIISTKKFPIIEYSKALAILKESSDTKKTNFELNDFSFGIDLKTEHERFLCEQYFQNQPLFVINYPKELKAFYMKTNTDNKTVAAVDLLLPKIGEICGGSERESDLNQLKNRCQSLNIDTKSLNWYLDMRKWGYFASAGFGLGFDRLLAYICGLENIRDAIPFPRVHGTINF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P53_MESAU
Sequence: MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLSTLPSSDSIEELFLSENVAGWLEDPGEALQGSAAAAAPAAPAAEDPVAETPAPVASAPATPWPLSSSVPSYKTYQGDYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVSSTPPPGTRVRAMAIYKKLQYMTEVVRRCPHHERSSEGDGLAPPQHLIRVEGNMHAEYLDDKQTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRRTEEKNFQKKGEPCPELPPKSAKRALPTNTSSSPQPKRKTLDGEYFTLKIRGQERFKMFQELNEALELKDAQALKASEDSGAHSSYLKSKKGQSASRLKKLMIKREGPDSD
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: DAPA_CAMHC
Sequence: MESTLIKGSMVAIITPFKNGKIDEVGYEKLIKREIANGINVIVPVGTTGESATLTHEEHRVCIEIAVDTCKGTDVKVLAGAGSNATHEAIGLAKFAQDHGADAVLSVAPYYNKPTQQGLYLHYKEIANSVEIPVLLYNVPGRTGCDIKADTVIRLFRECKNIIGVKEASGDIDRCVDLLSREPHMTVVSGEDSINYPILANGGKGVISVTANLLPDYVAKLCDYALKGDFVKSREINNELYELNKILFVESNPVPIKAAMYIAGLIETLEYRLPLCEPSKENYKKIEETIKKYKIKGL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLD_RHIEC
Sequence: MNRNVVLKLTGVERHYGQGDTLLTILKGADFSLAKGEIVALVAPSGTGKSTLLHVAGLLEHPDGGEVTINGHACDGLSDEKRTAIRRREIGFVYQFHHLLPEFSALENIMMPQLIAGLSWKEAQERAGQLLDYMRIGHRGSHRPAELSGGEQQRVAIARAVANAPTLLLADEPTGNLDPETASYVFDALEALVRQSGLAALIATHNHELAGRMDRRVTISDGKVVEF
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PDXB_VIBPA
Sequence: MKIIVDENMPYAEELFSQLGEVILKPGRTLTADDLIDIDALMIRSVTKVNAELISKANKLKFVGTATAGMDHVDQALLKEKGIFFTAAPGCNKVGVAEYAFSVMMVLAQQQGFSVFDKTVGIIGAGQVGSYLEKCLKGMGINVLINDPFKQEAGDPRSFTPLAELIEQSDIITLHTPITKDGLHPTHHLIDEKVLNGLRGDQILINAARGPVVDNQALKQRLMKQDGFTAALDVFEFEPEVDMELLPLLAFATPHVAGYGLEGKARGTTMIFNSYCEFLNNELRAHASDLLPTAPVPTMMLDRAWDEATLHNITQLIYDVRKDDALFRREISKPGAFDLMRKNYWDRREYSAVTLVGNETCNLAPLAELGFQIEVSQ
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_PSEFS
Sequence: MQAYQRDFIRFAIDRGVLRFGEFTLKSGRTSPYFFNAGLFNSGSALAQLGRFYAAAIVESGISFDVLFGPAYKGIPLAAATAVALAEHHGQDLPWCFNRKEAKAHGEGGSLVGAPLTGDVLIIDDVITAGTAIREVMQIIASQDGAKAAGVLIALNRQERGNGELSAIQEVERDFGIPVVSIVSLNQVLQFLEDDPQLKQHLPAVRAYREQFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: FETP_ALTMD
Sequence: MARTVFCRKLQKEADGLDFQLYPGELGKRIFDNISKEAWGEWQKKQTMLINEHKLNMMEPNARAFLEEKMSAYLFDDVEPTIEGYVPPEK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: NPIIA_PARBD
Sequence: MRRVSGILAVAAFTISAFAGVIQPVAKDARDSAELDVKLTQVDGTVIKAVVTNNGDKDLNILNLNFFRDTAPVKKVSIYSQGVEVPFGGIRVRHKTSDLSSDVITYLAPGESFEDEFDVAITSDLSQGGPVVLQTQGYVPTTDTGGKTLSGVVRYKSNKLEIDVDGTTAAKSFAAMNQFVKIAKLSSCEGSQGDDTRRALRDCASLSTLAAAQAWAGGPKMLEYFKANDDATRKLVADRFTAVALESSNLTGGSTTYYCRDPYNICTNNIIAYTIPAENLISNCPIYYTEFDNVNRKCHGQDRVTTSLHEFTHASSVFSPGTKDIAYGYNACILLSTRDALNNADTFALFAQSINAGC
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog PADG_00776, Deuterolysin PADG_00776.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FRS1_ARATH
Sequence: MSSGECSNVQLDDHRKNNLEIDEGREFESKEEAFEFYKEYANSVGFTTIIKASRRSRMTGKFIDAKFVCTRYGSKKEDIDTGLGTDGFNIPQARKRGRINRSSSKTDCKAFLHVKRRQDGRWVVRSLVKEHNHEIFTGQADSLRELSGRRKLEKLNGAIVKEVKSRKLEDGDVERLLNFFTDMQVENPFFFYSIDLSEEQSLRNIFWVDAKAMHGCRPRVILTKHDQMLKEAVLEVFPSSRHCFYMWDTLGQMPEKLGHVIRLEKKLVDEINDAIYGSCQSEDFEKNWWEVVDRFHMRDNVWLQSLYEDREYWVPVYMKDVSLAGMCTAQRSDSVNSGLDKYIQRKTTFKAFLEQYKKMIQERYEEEEKSEIETLYKQPGLKSPSPFGKQMAEVYTREMFKKFQVEVLGGVACHPKKESEEDGVNKRTFRVQDYEQNRSFVVVWNSESSEVVCSCRLFELKGFLCRHAMIVLQMSGELSIPSQYVLKRWTKDAKSREVMESDQTDVESTKAQRYKDLCLRSLKLSEEASLSEESYNAVVNVLNEALRKWENKSNLIQNLEESESVTAQDLPIHEEQNNTYDMNKDDNVADTGQEYSLQEVWKVTALQEQRNRYSILDDYLSAQHMSHEMGQINSMASNRNGYCSVHQNIHSLQGQSITHPRLYETEQSSFRPEAMYERLQDMVKDLN
What is the function of this protein?
Putative transcription activator involved in regulating light control of development.
What are the official names of this protein?
Protein FAR1-RELATED SEQUENCE 1.
What is the protein family that this protein belongs to?
Belongs to the FHY3/FAR1 family.
What are the subcellular locations of this protein?
Nucleus. Note=The nuclear localization is independent of the light treatment.
Protein: Y4354_BACCZ
Sequence: MKVSYHGHSVVKIETNGKVILIDPFLTGNPKTDLKAEDVNVDAILLSHGHGDHVGDTVELAKKNNAVVVAPFELATFLSWQGVNTHPMHIGGSHEFDFGKVKFTQAFHGSSYIDEENKTITYTGMPAGILFTAEEKTLYHAGDTALFSDMKLIGELNNIDVAFLPIGDNFTMGPEDAVLAAKWVQAKTVVPMHYNTFPVIEQDPYQFVEKLQNCTGKVLEAGESITL
What are the official names of this protein?
UPF0173 metal-dependent hydrolase BCE33L4354.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: HEM3_RICCK
Sequence: MTHSIRIGTRKSPLALIQTNLVIQQIKQFVPDINYKIVPITTSGDLIQNKPLYDIGGKALFLKEIEQALLDKKIDLAVHSLKDVPGRIPEDLIIAAVLEREDPRDVFVCLKYKSIEELPQNAIIGSSAVRRKTFIEKIRSDLKVTVFRGNVDSRIKKLMNGEVDATILAYAGLKRLNAFNPQYCHLIEYSQMLPCIGQGVIAVEIRKDDNAMLETCNQINHLTTFELIKPERAFLEYLDANCRTPIAAYSKYLDKDNIETDFMLGNLESSKITFHTETTNIKTSKEAGIKAAKIMLSELER
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CYB_LAGAU
Sequence: MINIRKTHPLMKILNNAFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTSTAFSSVAHICRDVNYGWFIRYLHANGASMFFICLYAHIGRGLYYGSYMFQETWNIGVLLLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAAVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTTKDILGALFLILALLALTLFTPDLLGDPDNYTPANPLSTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILILIFIPMLQTSKQRSMMFRPFSQLLFWTLIADLLTLTWIGGQPVEHPYIIVGQLASILYFLLILVLMPTVSLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UFD4_YEAST
Sequence: MSENNSHNLDEHESHSENSDYMMDTQVEDDYDEDGHVQGEYSYYPDEDEDEHMLSSVGSFEADDGEDDDNDYHHEDDSGLLYGYHRTQNGSDEDRNEEEDGLERSHDNNEFGSNPLHLPDILETFAQRLEQRRQTSEGLGQHPVGRTLPEILSMIGGRMERSAESSARNERISKLIENTGNASEDPYIAMESLKELSENILMMNQMVVDRIIPMETLIGNIAAILSDKILREELELQMQACRCMYNLFEVCPESISIAVDEHVIPILQGKLVEISYIDLAEQVLETVEYISRVHGRDILKTGQLSIYVQFFDFLTIHAQRKAIAIVSNACSSIRTDDFKTIVEVLPTLKPIFSNATDQPILTRLVNAMYGICGALHGVDKFETLFSLDLIERIVQLVSIQDTPLENKLKCLDILTVLAMSSDVLSRELREKTDIVDMATRSFQHYSKSPNAGLHETLIYVPNSLLISISRFIVVLFPPEDERILSADKYTGNSDRGVISNQEKFDSLVQCLIPILVEIYTNAADFDVRRYVLIALLRVVSCINNSTAKAINDQLIKLIGSILAQKETASNANGTYSSEAGTLLVGGLSLLDLICKKFSELFFPSIKREGIFDLVKDLSVDFNNIDLKEDGNENISLSDEEGDLHSSIEECDEGDEEYDYEFTDMEIPDSVKPKKISIHIFRTLSLAYIKNKGVNLVNRVLSQMNVEQEAITEELHQIEGVVSILENPSTPDKTEEDWKGIWSVLKKCIFHEDFDVSGFEFTSTGLASSITKRITSSTVSHFILAKSFLEVFEDCIDRFLEILQSALTRLENFSIVDCGLHDGGGVSSLAKEIKIKLVYDGDASKDNIGTDLSSTIVSVHCIASFTSLNEFLRHRMVRMRFLNSLIPNLTSSSTEADREEEENCLDHMRKKNFDFFYDNEKVDMESTVFGVIFNTFVRRNRDLKTLWDDTHTIKFCKSLEGNNRESEAAEEANEGKKLRDFYKKREFAQVDTGSSADILTLLDFLHSCGVKSDSFINSKLSAKLARQLDEPLVVASGALPDWSLFLTRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKNKSKGSKDLRNDEALQQLGRITRRKLRISRKTIFATGLKILSKYGSSPDVLEIEYQEEAGTGLGPTLEFYSVVSKYFARKSLNMWRCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAGAFLLS
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
What are the official names of this protein?
Ubiquitin fusion degradation protein 4, UB fusion protein 4, HECT-type E3 ubiquitin transferase UFD4.
What is the protein family that this protein belongs to?
Belongs to the UPL family. K-HECT subfamily.
Protein: RL2_EHRRG
Sequence: MGIKNLNSVTPSLRGTVLLDKSTLWKGRPEKSLVGYKISHGGRNSRGVITVRHRGKGHKRLYRIIDFKRKKVGVPATVERLEYDPNRTAFIALLSYDDGEKSYIIAPHGLKKGDVIMSGNGSDILPGNCLMLKLIPVGTFVHNVELRPGGGGIIARSAGTYAQLMSKDGIYVLLRLSSGEIRKVLADCCATIGIVSNLDNQNVKLGKAGRSRWLGIRPTVRGVAMNPIDHPHGGGEGKTSGGRNPVTPWGVSTKGKKTRKKNKSSNKYIKRVSDKG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RL36_LISMO
Sequence: MKVRPSVKPMCEKCKVIRRKGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: HSLO_OCEIH
Sequence: MKDYLIKATANNGKIRAYAVQSTNTIEEARRRQDTFATASAALGRTITITAMMGAMLKGDDSITTKVMGNGPLGAIVADADADGHVRGYVTNPHVDFDLNDKGKLDVARAVGTEGNISVIKDLGLKDFFTGETPIVSGEISEDFTYYYATSEQLPSAVGAGVLVNPDHTILAAGGFIVQVMPGAEEEVINELEDQIQAIPAISSLIREGKSPEEILTQLFGEECLTIHEKMPIEFRCKCSKDRLAQAIIGLGNDEIQAMIEEDQGAEATCHFCNEKYHFTEEELEDLKQ
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_SYNJA
Sequence: MIKTYVVTHLRKMEEGIPEGLQVVDLPMTSEERTQVRRRLETPSGLVLNLALPTGTVLQPGQILCVVEGVAYRVVAAPEEVLVIYPRSLKEAAQVGHLIGNLHRPIDLSGEVIAILYDAALEERLRNLGLVVVREMRSFAKTPLPGHSH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NET3B_ARATH
Sequence: MGETSKWWWIGANHNTSNSSPWLNSTLSELDSKTKEMLSVIDEVEDEGDSLMKRAKINYENKPKLIELLEELYRSHRSLAQKHDLLIKTSSLNSDSHNSSSCDEIRSEVCEETESSDVEAETEKDQIVEFDDGDETMKEELEILREENRVYKEKKEVVTRLLANLVRVCFCFQFNWEIFSYHLLRFCLLFSHDPIGGWVICTKRFRYYFLIMFSF
What is the function of this protein?
Plant-specific actin binding protein.  May be part of a membrane-cytoskeletal adapter complex.
What are the official names of this protein?
Protein NETWORKED 3B.
What is the protein family that this protein belongs to?
Belongs to the NET family.
Protein: LIS12_POSPM
Sequence: MSILSERQKDDLNKSIAEYLYAQDLTEIADSLCARLSLDYKSEPNSKYAGLLEKKWVSVIRLQKKLIESENRYTALQEDIAAGPARRRDAQVDWLPTAPARYTLTSHRAPITRVAFHPTFSLLASASEDTTVKIWDWETGSFERTLKGHTREVWGVDFDSKGSFLATCSSDLSIKVWDTQQWDNAGYSGKTLRGHEHTVSTVKFLPGDDLIASASRDKTIRIWEVATTFCIRTITGHEDWVRMTVPSTDGTLLGSCSSDNTARVWDPTSGVMKMEFRGHGHIVEVIAFAPLASYAAIRELAGLKAATKAPGAYIATGSRDKTVKIWDVHSGQELRTVSGHNDWIRGLVFHPSGKHLLSASDDKTIRVWELSTGRCMXVVEAHSHFITCLAWGPPVSAVARVELPRTPFCGDPKPIASRIMEEFNPRP
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for nuclear migration during vegetative growth as well as development.  Required for retrograde early endosome (EE) transport from the hyphal tip.  Required for localization of dynein to the mitotic spindle poles.  Recruits additional proteins to the dynein complex at SPBs.
What are the official names of this protein?
Nuclear distribution protein PAC1-2, Lissencephaly-1 homolog 2, LIS-1 2, nudF homolog 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Protein: HBEAG_HBVD3
Sequence: MQLFHLCLIISCSCPTVQASKLCLGWLWGMDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGVNLEDPASRDLVVSYVNTNMGLKFRQLLWFHISCLTFGRETVIEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: RL14_BACMK
Sequence: MIQQESRLKVADNSGARELLTIKVLGGSGRKYAYIGDIIVATVKQATPGGVVKKGDVVKAVVVRTKSGARRPDGSYIKFDENAAVIIKDDKSPRGTRIFGPVARELRDSNFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ICYA_MANSE
Sequence: GDIFYPGYCPDVKPVNDFDLSAFAGAWHEIAKLPLENENQGKCTIAEYKYDGKKASVYNSFVSNGVKEYMEGDLEIAPDAKYTKQGKYVMTFKFGQRVVNLVPWVLATDYKNYAINYNCDYHPDKKAHSIHAWILSKSKVLEGNTKEVVDNVLKTFSHLIDASKFISNDFSEAACQYSTTYSLTGPDRH
What is the function of this protein?
This protein binds a chromophore: biliverdin IX, isomer gamma.  Mixed with lipoprotein-bound carotenes, this blue protein provides hornworms with their green cryptic coloration which serves a camouflage.
What are the official names of this protein?
Insecticyanin-A, INS-a, Blue biliprotein.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_BEUC1
Sequence: MPSILDKVLRMGEGRILKKLTGIVAQVNAHEDTVREFTDAELREETDVFKARLADGETLEAILPEAFATVREAARRTLGQRPHDVQVMGGAALHLGNIAEMKTGEGKTLAATLPAYLNALSGDGVHVVTVNDYLAQYQSDLMGRVYRFLGLTTGCILSGQKPEERRRHYAADITYGTNNELGFDYLRDNMAWSSGELVQRGHNFVIVDEVDSILIDEARTPLIISGPASGDANKWYAEFARVARRLTRESDYEVDEKKRNVGVLEPGIEKVEDYLGIDNLYESLNTPLIGFLNNAIKAKELFKRDKDYVVLKGEVLIVDEHTGRILAGRRYNEGMHQAIEAKEGVAIKAENQTLATITLQNYFRLYGKLAGMTGTAMTEAAEFQGTYKVGVVPIPTNMPMARLDKPDLVFKNEDGKFDAVVEDIVERHAAGQPVLVGTTSVEKSELLSTKLKRQGVPHEVLNAKQHAREASIVAMAGRKGAVTVATNMAGRGTDIMLGGNAEHLAIATLAEQGLDPNETPEEYEAAWPDALEEATTSVAAEHDEVVDLGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSMGDDLMRLFNSGLAERFMGSSAYPDDMPLESKLVTRGIASAQGQVEARNFEIRKNVLKYDDVLSRQRAVIYTDRRRVLEGEDLAEQVQGFLTDVVTAYIESATQAGAPESWDLDELWTALKAVYPISITPEEVVSEAGNATRVTPEMLTREILSDAEHAYARREEELTPDVMRQLERRVVLAVLDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGFQLFSAMRDAIKEEAVGYLFNLEVKRPEPAESAEESTDGAPVVPAVPTGSDGEPLAPEQEAVPAGEPERPAKRRPAARVATRPAAEVDPLGLDTPERPAALQYSAPSSDGGSSFSEGRVVRSEGGTSGGSARPAAGASSGGGGGGANREARRRAAKAAKKRR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: NANT_SALPC
Sequence: MSTSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILMTFVAAAALWFCFAGNLQNAAIVAGLGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPTYLKTELAYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFAIGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTAQRAAGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSGAVPLGSGKGAFVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAA_RHOP2
Sequence: MSNMEHDRWSRVKGRLRSSVGEDVYSSWFARMDLEAVQPESVHLSVPTRFLKSWIQTHYSDKVLTCWQAELPEVCRIDLTVRSPMRAAVAKEAAAPVEHRRAEHRPATETRSHATVPASSNHDALGGSPLDPRLTFASFVVGRSNTLAHAAAKQVAEGRRGDPVMFNPLYIHSGVGLGKTHLLQAVTWAGNTGIERKVLYLTAEKFMYGFVAALKTQTSLAFKEALRGIDVLVIDDLQFLQGKTTQAEFCHTLNALIDAGRQVVVAADRPPSDLESLDERVRSRLAGGLVVEMAPLGEDLRLGILKSRVVAARAHHASFDVPAPVLEYLARAITHNGRDLEGAINRLLAHSKLNAQPVTLEMAEHEVRDLIRPQEPKRIKIEDIQRIVARQYNVSRSDLLSSRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEGLVSKDTTLSDEVDSLKRQLQE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADA_BACP2
Sequence: MSLLDVLANQHAAMMPEEYKHRSVDEMEQRVVDIKRAFGSKLFIPGHHYQKDEVIQFADATGDSLQLAQIAADNKEAEYIVFCGVHFMAETADMLSKKNQKVLLPDMRAGCSMADMANMKQTDRAWEQLTDLFGETILPLTYVNSTADIKAFVGKHGGATVTSSNAKKMLEWALTQKERILFLPDQHLGRNTAFDLGISLEEMAVWDQIEERLITDQPLSRIKMILWKGHCSVHEKFTVRNIEETRKRDRDIQILVHPECTHEVVTASDLAGSTKFIIDTIKEAPAGSKWAIGTEMNLVKRIINQHPDKQIESLNPDMCPCLTMNRIDLPHLLWSLESIEKGDPVGFIQVNEDTTKDALLALNKMLIIK
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.