PharMolix/UniProtQA huggingface dataset:
Protein: PANC_BACSU
Sequence: MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKARQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGEKNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGLISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGERDPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNIIIDIREMERI
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S38A9_XENTR
Sequence: MDSDQTPLINPSLFEECAQNHFAATDPRSRRPFHIEPSYITSINDDDPQRITSVASAMNKRIHYYSKLSNPSDKGLIAPDHVLPAPEEIYVYSPLGTALKIDGSDGTGKNSSIVTIFMIWNTMMGTSILSIPWGIKQAGFTTGVCILFLMGILTLYCCYRVVKSRGTIPLTDTSNWEFPDVCQYYFGSFGRWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIYNYVNDVNVTDDVLSNNGSDKVICPNPDSTRPLNKSMDTYFGNGTNYEQFETWWSKTNTVPFYLVVLLLPLLSFRSPSFFAKFNILGTVSIIYLVSLVTLKAAHLGFHLRFSWNQVQEFFVPEFRLSFPQLTGILTLAFFIHNCIITLLKNNRNQKNNVRDLSIAYLLVGLTYIYVGVAVFASFPSPPLSKQCIQQNFLDNFPSSDILAFVARIFLLFQMMTVYPLLGYLVRVQLLGHIFGDIYPSVFHVLALNIAVVGVGVIMARFYPNIGGIIRFSGAACGLAFVFVYPSLIHMISLHRRGQLKVHSILIHVSIIVLGIANLIAQFFM
What is the function of this protein?
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels.  Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids.  Acts as an arginine sensor.  Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation.  However, the transport mechanism is not well defined and the role of sodium is not clear.  Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency.
What are the official names of this protein?
Neutral amino acid transporter 9, Solute carrier family 38 member 9.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Protein: VL1_HPV6A
Sequence: MWRPSDSTVYVPPPNPVSKVVATDAYVTRTNIFYHASSSRLLAVGHPYFSIKRANKTVVPKVSGYQYRVFKVVLPDPNKFALPDSSLFDPTTQRLVWACTGLEVGRGQPLGVGVSGHPFLNKYDDVENSGSGGNPGQDNRVNVGMDYKQTQLCMVGCAPPLGEHWGKGKQCTNTPVQAGDCPPLELITSVIQDGDMVDTGFGAMNFADLQTNKSDVPIDICGTTCKYPDYLQMAADPYGDRLFFFLRKEQMFARHFFNRAGEVGEPVPDTLIIKGSGNRTSVGSSIYVNTPSGSLVSSEAQLFNKPYWLQKAQGHNNGICWGNQLFVTVVDTTRSTNMTLCASVTTSSTYTNSDYKEYMRHVEEYDLQFIFQLCSITLSAEVMAYIHTMNPSVLEDWNFGLSPPPNGTLEDTYRYVQSQAITCQKPTPEKEKPDPYKNLSFWEVNLKEKFSSELDQYPLGRKFLLQSGYRGRSSIRTGVKRPAVSKASAAPKRKRAKTKR
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: LEUD_BURP1
Sequence: MEKFNVHTGVVAPLDRENVDTDAIIPKQFLKSIKRTGFGPNAFDEWRYLDHGEPGQDNSKRPLNPDFVLNQPRYQGASVLLARKNFGCGSSREHAPWALQQYGFRAIVAPSFADIFFNNCYKNGLLPIVLTEQQVDHLFNDTYAFNGYQLTIDLDAQVVRAPDGREYPFEITAFRKYCLLNGFDDIGLTLRHADKIRQFEAERLAKQPWLDNRLVG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: YIDC_NOSS1
Sequence: MDFGIGFLSNNVMLPIIDFFYSVVPSYGLAIVALTLIIRFALYPLSAGQIRNMRKMRIVQPLMQKRMAEIKERYKDDPQKQQEEMMNVQKEFGNPLAGCLPLLLQMPVLLALFATLRGSPFAGVNYSVNLQIFPSEQIERIQPQAFATPPQNIYIADGEHTKVTAILPGGNKLAVGEKTKIQYQTLEGKPFPVLLAEHPESKLSPEWKITKGEDRIKIDAEGNIEALQPGDVTIQGTIPGLAADKGFLFIDALGRVGAIDPDNTIHWDIVGMIVFFGISLYVSQMLSGQNSSGGNPQQDTVNKITPVIFSGMFLFFPLPAGVLMYMVIGNVFQTLQTYILSREPLPEEIQKIVETQEKQAVAEQKTLPFEPKSSKKKTTG
What is the function of this protein?
Probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRPE_LATSK
Sequence: MTKQEKAENQEKPTEETVEETPKKETPFEPVMEADEVEETTEAQAPVEEADDKLAELQKKYDAMEDSFLRSQAEIKNIQMRNQKEQANLLKYDGQSLAKDVLPVLDNLERALAAEATDESLKKGVQMTYDHMKHALEDHGVKEIEAQGQAFDPTIHQAVQTVAVDGDQKADTVVQVFQKGYYLKDRVLRPAMVVVAQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLD_ECO57
Sequence: MNKILLQCDNLCKRYQEGSVQTDVLHNVSFSVGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGQPMSKLSSAAKAELRNQKLGFIYQFHHLLPDFTALENVAMPLLIGKKKPAEINSRALEMLKAVGLEHRANHRPSELSGGERQRVAIARALVNNPWLVLADEPTGNLDARNADSIFQLLGELNRLQGTAFLVVTHDLQLAKRMSRQLEMRDGRLTAELSLMGAE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BCHD_CERS4
Sequence: MPLGPWERVEAALTLLAIDPAGLKGLWLRARASALRDRITGALGALPLPVRRIHPTIGDDALFGGLDLAATLSAGTPVVQKGILDEPAVLVLAMAERTLPGLAARLGTALDAPRHCLIALDEGAERDELLPLGLVDRLALFLDLDGLPWGETREIALDPERLAAARARLAAVATPPEAAATLARVAAQLGIASLRAPTLALAAARAQAAWEGHAAVTDEDIRRAADLVFAHRAMPASEEAPPEPEPEPPEDQPDDSPPPPEQQQGEEMFPEEMLVEAVRAALPADLLEQLAAGRAARMARGATGTGSAKAGNRRGRPLPSRMGRLGTGARIDLVGTLRAAAPWQPLRRRQQKTDAVLLVRPSDIRIKRFRETSDRVLIFAVDASGSSAMARLSEAKGAVELLLGQAYARRDHVSLLAFRGRDAELILPPTRSLVQTKRRLAGLPGGGGTPLAHGLRLALAVGLQARARGMTPTVALLTDGRGNIALDGSANRAQAEEDALKLAASLRGSGLPAVVIDTANRPQPSLAALARALDAPYIALPRADAHKLSNVLGAAMGD
What is the function of this protein?
Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
What are the official names of this protein?
Magnesium-chelatase 60 kDa subunit, Mg-chelatase subunit D, Mg-protoporphyrin IX chelatase.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunits D/I family.
Protein: NUSG_SALTY
Sequence: MSEAPKKRWYVVQAFSGFEGRVATSLREHIKLHNMEELFGEVMVPTEEVVEIRGGQRRKSERKFFPGYVLVQMVMNDASWHLVRSVPRVMGFIGGTSDRPAPISDKEVDAIMNRLQQVGDKPRPKTLFEPGEMVRVNDGPFADFNGVVEEVDYEKSRLKVSVSIFGRATPVELDFSQVEKA
What is the function of this protein?
Participates in transcription elongation, termination and antitermination.  In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing.  In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho.  May be required to overcome a kinetic limitation of Rho to function at certain terminators.  Also involved in ribosomal RNA transcriptional antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusG.
What is the protein family that this protein belongs to?
Belongs to the NusG family.
Protein: DPY30_BOVIN
Sequence: MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN
What is the function of this protein?
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation.  Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.  May play some role in histone H3 acetylation.  In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci.  May also play an indirect or direct role in endosomal transport (By similarity).
What are the official names of this protein?
Protein dpy-30 homolog, Dpy-30-like protein, Dpy-30L.
What is the protein family that this protein belongs to?
Belongs to the dpy-30 family.
What are the subcellular locations of this protein?
Nucleus. Golgi apparatus, trans- Golgi network.
Protein: MTH11_DROME
Sequence: MGMFRVEYLLLGILVIGVRSRDIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGDRVSVPKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSVIKKHVLNDMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSLIVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCCNLYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVFYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFYAPLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEIIAFICEMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRLIRKRIQNRNITSLELTNTSRPVESEKMADVELGK
What are the official names of this protein?
Probable G-protein coupled receptor Mth-like 11, Protein methuselah-like 11.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PPIA_CHLAE
Sequence: MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
What is the function of this protein?
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity).  Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity).  Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity).  In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity).  Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity).  Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity).  Plays an important role in platelet activation and aggregation (By similarity).  Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).  Binds heparan sulfate glycosaminoglycans (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Protein: GCSPB_CAUVC
Sequence: MNNVGRPTRPEAANDAANGHETLTGARGLLQDEALIFELDGWNKTGVDLPPVTAAPSSDLNGLLRDAPIGLPGLSEPETVRHYVRLSQKNHAIDLALYPLGSCTMKHNPRLNEKMARLPGFSDIHPLQPQSTVQGALELMDRLAHWLKTLTGMPAVALTPKAGAHGELCGLLAIRAAHEAAGNGHRKTVLAPTSAHGTNPATAAFVGYTVVEIAQTEDGRVDLADLESKLGDHVAAIMVTNPNTCGLFERDVVEIARLTHAAGAYFYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSEALAPFAPTPWLTHGDNGFELAEHAGDDDAKTAFGRMSAFHGQMGMYVRAYAYMLSHGADGLRQVAEDAVLNANYIKAQLKDVMSPAFPEGPCMHEALFDDSWLEGTGVTTLDFAKAMIDEGFHPMTMYFPLVVHGAMLIEPTETESKHELDRFIAALRALAGAAKAGDTERFKGAPFHAPLRRLDETQAARKPRLRWKPVAAAPLAAE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: Y2043_BURMA
Sequence: MSADSADSVPSPRSAFATTLQIVSVVSFTFICYLTIGLPLAVLPGFVHDELGFSAIVAGAAISVQYFATLASRPLAGRCADTLGPKRTVLRGLAACGASGALLLSAFAFARWPAASIGLLVASRLVLGIGESLVGTGAILWGIGRVGTAHNARVISWNGIATYGALAIGAPVGVAISHALIPAVLGMLVIALAALGYYLARLITPVPLVHGERMSYASVLTRVLPHGLGLALGSAGFGSIATFITLYYAARHWPNAALSLTVFGTLFIGARLLFANTIKTHGGFRVAIVSFAFECAGLLMLWLAPVPHVALVGAALTGFGFALIFPALGVEAVALVPPASRGAALSAYSVFLDLSLGITGPLAGYVAGAFGYPQVFLCAAVAAAAGVALSTVLYQRQARLSGSGAAA
What are the official names of this protein?
Uncharacterized MFS-type transporter BMA2043.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YhhS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYSH_ECO24
Sequence: MSKLDLNALNELPKVDRILALAETNAELEKLDAEGRVAWALDNLPGEYVLSSSFGIQAAVSLHLVNQIHPDIPVILTDTGYLFPETYRFIDELTDKLKLNLKVYRATESAAWQEARYGKLWEQGVEGIEKYNDINKVEPMNRALKELNAQTWFAGLRREQSGSRANLPVLAIQRGVFKVLPIIDWDNRTIYQYLQKHGLKYHPLWDEGYLSVGDTHTTRKWEPGMSEEETRFFGLKRECGLHEG
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERS_STRPC
Sequence: MRRELLLEKIETYKAIMPWYVLDYYQSKLAVPYSFTTLYEYLKEYKRFFDWLMDADLTQAPKIADIDLSTLEHLTKKDLEAFVLYLRERPSLNTYSTKEGLSQTTINRTLSALSSLYKYLTEEVENDQGEPYFYRNVMKKVSTKKKKETLASRAENIKQKLFLGDETLAFLDYVDKEYEQKLSNRAKSSFRKNKERDLAIIALLLASGVRLSEAVNLDLKDVNLNMMIIEVIRKGGKRDSVNVAGFAKGYLESYLAVRQRRYKAEKQDLAFFLTEYRGVPNRMDASSIEKMVGKYSEDFKIRVTPHKLRHTLATRLYDATKSQVLVSHQLGHSSTQVTDLYTHIVNDEQKTALDNL
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.
What are the official names of this protein?
Tyrosine recombinase XerS.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNMT_THLFG
Sequence: MAVEGKQVAPKKAIIVELLKKLELGLVPDDEIKKLIRIQLGRRLQWGCKSTYEEQIAQLVNLTHSLRQMKIATEVETLDDQMYEVPIDFLKIMNGSNLKGSCCYFKNDSTTLDEAEIAMLELYCERAQIKDGHSVLDLGCGQGALTLYVAQKYKNSRVTAVTNSVSQKEFIEEESRKRNLSNVEVLLADITTHKMPDTYDRILVVELFEHMKNYELLLRKIKEWMAKDGLLFVEHICHKTFAYHYEPIDEDDWFTEYVFPAGTMIIPSASFFLYFQDDVSVVNHWTLSGKHFSRTNEEWLKRLDANVELIKPMFVTITGQCRQEAMKLINYWRGFCLSGMEMFGYNNGEEWMASHVLFKKK
What is the function of this protein?
Involved in the biosynthesis of protoberberine alkaloids.  N-methyltransferase with a substrate preference for (R,S)-norreticuline but also active with dimethoxytetrahydroisoquinoline.
What are the official names of this protein?
(S)-coclaurine N-methyltransferase, TfCNMT.
What is the protein family that this protein belongs to?
Belongs to the CFA/CMAS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEH_CARHZ
Sequence: MNALGRHVIAELYGCGFDVLNDVKRVEEIMVRSALEAGAEIREVAFHKFSPQGVSGVVVISESHLAIHTWPELGYAAVDVFTCGDTVDPWDATNYLAKEFGAKYMTAKETKRGVMVEEFAESQAVNL
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: ARBH_HHV8P
Sequence: MDEDVLPGEVLAIEGIFMACGLNEPEYLYHPLLSPIKLYITGLMRDKESLFEAMLANVRFHSTTGINQLGLSMLQVSGDGNMNWGRALAILTFGSFVAQKLSNEPHLRDFALAVLPVYAYEAIGPQWFRARGGWRGLKAYCTQVLTRRRGRRMTALLGSIALLATILAAVAMSRR
What is the function of this protein?
Plays a role in the protection against apoptosis mediated by cytotoxic cells during the immune response to acute and persistent viral infection.  Contributes therefore to latency establishment.  Plays also a role in the inhibition of host starvation-induced autophagy which ultimately contributes to the viral chronic infection.  Participates also in the viral genome replication within host nucleus (PubMed:28053098).
What are the official names of this protein?
Apoptosis regulator Bcl-2 homolog.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein. Host mitochondrion. Host nucleus, host nucleolus. Host nucleus.
Protein: RL10_CYTH3
Sequence: MTKEEKAIIIQEVAQKIAGAATFYITDGSGMTVDQVNKFRKLCFSKGVEYKVVKNSLIKKALQQLNIDHTALNGAALKGASGLMFSDTANVPAKLLKQFHKGGVAKPEFKGASVFADFYVGKDKLDALASIKSKEELIGDIIALLQAPAQRVIGGLTNESRVFAEQA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: SPH_STRP1
Sequence: MTRQQTKKNYSLRKLKTGTASVAVALTVLGAGFANQTTVKAEGAKIDWQEEYKKLDEDNAKLVEVVETTSLENEKLKSENEENKKNLDKLSKENQGKLEKLELDYLKKLDHEHKEHQKEQQEQEERQKNQEQLERKYQREVEKRYQEQLQKQQQLETEKQISEASRKSLSRDLEASRAAKKDLEAEHQKLEAEHQKLKEDKQISDASRQGLSRDLEASRAAKKELEANHQKLEAEHQKLKEDKQISDASRQGLSRDLEASRAAKKELEANHQKLEAEAKALKEQLAKQAEELAKLRAGKASDSQTPDTKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN
What are the official names of this protein?
Immunoglobulin G-binding protein H, IgG-binding protein H.
What is the protein family that this protein belongs to?
Belongs to the M protein family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor.
Protein: KGUA_MYCPA
Sequence: MTADGGPDVRHGTRPEPSGDGRVVVLSGPSAVGKSTVVRCLRERVPNLHFSVSATTRAPRPGEVDGVDYHFVSPARFQQLIDEGALLEWAEIHSGLHRSGTLAAPVRAAVARGCPVLIEVDLAGARAVKKAMPEALTVFLAPPSWEDLEARLIGRGTETPEVIARRLQTARVEMAAQHDFDRVVVNSRLESACAELVSLLVGTAPDRHDTSGRTGRQTTSHPD
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOE_BACC1
Sequence: MDFKQYSPEELKECSMIEVVHSVLGDKKQATTFNELVQEIAQVLGLSQEQVNAKIAQFYTDLNIDGRFINLGENRWGLRSWYPYEQIDEEILPQPKPKKKRKVEEDGFDDYIDEDEDDFDDVDGNEDEDDDVEDLDKVLEDEDGDDDDLDDLDEDEDDFAEEELEYDETEEEEEEEL
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: PSB28_SYNY3
Sequence: MAEIQFSKGVAETVVPEVRLSKSKNGQSGMAKFYFLEPTILAKESTDDITGMYLIDDEGEIITREVKGKFINGRPTAIEATVILNSQPEWDRFMRFMERYGAENGLGFSKSE
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.