PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_SHIFL
Sequence: MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDYKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSWFDNYLGVVSLIRIKNGTLRKGDKVKVMSTGQTYNADRLGIFTPKQVDRTELKCGEVGWLVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTSREVIYVDSPSKLPAVNNIYELREPIAECHMLLPQAYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINGERVDALALITHRDNSQNRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DEOB_ALIFM
Sequence: MKRAIILVLDSFGIGAAGDADKFGDVGSDTMGHIAEQCDKGLADNGNRKGSLTLPNLSKLGLAMAGKESTGKFSAGLDANAEIIGAYGHAAELSSGKDTPSGHWEIAGVPVLFDWGYFTDKENSFPKELTDRILERANLPGYLGNCHASGTQVLDDLGEEHMKTGMPIFYTSADSVFQIACHEETFGLDNLLTLCQIAREELEDYNIGRVIARPFIGPGKGQFERTGNRRDLSVEPPAATILQKLVDEKGGQVHSIGKISDIYAGCGITKKTKATGIPALFDATKEAIEQAGDNTIVFTNFVDFDSAYGHRRDVAGYAAALEYFDGRLPEIMDMLQEDDILILTADHGCDPTWPGTDHTREHIPVLVYGHKVPAGSLGRRDTFADIGQTLAEYFETSDMEYGKSFL
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4753_PSEAE
Sequence: MALTQEQKKQFKSIGHHLKPVLIVAENGLTEGVLAELERALNDHELIKVKLALAERDDRRALLDELCAQSRSDLVQSIGKMALVYRKNPKPNKNLSNISRFAGI
What are the official names of this protein?
Probable RNA-binding protein PA4753.
Protein: RL21_PYRIL
Sequence: MVKRTHGYRYKSRKLLRKKPRERGLSGLSRLLYEYKPGDRVVIDIDPTFVENAPHRRYQGKVGVVIGTRGRAYVIETYLGDKKKILVVTPEHLKPHQGGS
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: CRWN1_ARATH
Sequence: MSTPLKVWQRWSTPTKATNPDSNGSSHGTGLDMVTPVSGRVSEIQFDDPRILPEKISELEKELFEYQHSMGLLLIEKKEWSSQYEALQQAFEEVNECLKQERNAHLIAIADVEKREEGLRKALGIEKQCALDLEKALKELRAENAEIKFTADSKLTEANALVRSVEEKSLEVEAKLRAVDAKLAEVSRKSSDVERKAKEVEARESSLQRERFSYIAEREADEATLSKQREDLREWERKLQEGEERVAKSQMIVKQREDRANESDKIIKQKGKELEEAQKKIDAANLAVKKLEDDVSSRIKDLALREQETDVLKKSIETKARELQALQEKLEAREKMAVQQLVDEHQAKLDSTQREFELEMEQKRKSIDDSLKSKVAEVEKREAEWKHMEEKVAKREQALDRKLEKHKEKENDFDLRLKGISGREKALKSEEKALETEKKKLLEDKEIILNLKALVEKVSGENQAQLSEINKEKDELRVTEEERSEYLRLQTELKEQIEKCRSQQELLQKEAEDLKAQRESFEKEWEELDERKAKIGNELKNITDQKEKLERHIHLEEERLKKEKQAANENMERELETLEVAKASFAETMEYERSMLSKKAESERSQLLHDIEMRKRKLESDMQTILEEKERELQAKKKLFEEEREKELSNINYLRDVARREMMDMQNERQRIEKEKLEVDSSKNHLEEQQTEIRKDVDDLVALTKKLKEQREQFISERSRFLSSMESNRNCSRCGELLSELVLPEIDNLEMPNMSKLANILDNEAPRQEMRDISPTAAGLGLPVTGGKVSWFRKCTSKMLKLSPIKMTEPSVTWNLADQEPQSTEQANVGGPSTTVQAATTYSFDVQKAESETGTKEVEVTNVNSDGDQSDINSKAQEVAADSLSNLDVDGQSRMKGKGKARTRRTRSVKDVVDDAKALYGESINLYEPNDSTENVDDSTKASTGETGRSDKAISKNGRKRGRVGSLRTCTTEQDGNESDGKSDSVTGGAHQRKRRQKVASEQQGEVVGQRYNLRRPRRVTGEPALSKKNEDIGGVQQEEGIHCTQATATASVGVAVSDNGVSTNVVQHEATADSEDTDAGSPKRTDESEAMSEDVNKTPLRADSDGEDDESDAEHPGKVSIGKKLWTFLTT
What is the function of this protein?
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments (By similarity).  Required for nucleus structure organization (e. g.  size and shape) (PubMed:17873096, PubMed:24308514, PubMed:23396599, PubMed:24824484).
What are the official names of this protein?
Protein CROWDED NUCLEI 1, Protein KAKU2, Protein LITTLE NUCLEI 1.
What is the protein family that this protein belongs to?
Belongs to the CRWN family.
What are the subcellular locations of this protein?
Nucleus membrane; Peripheral membrane protein. Nucleus, nucleoplasm. Nucleus lamina. Note=Recruited to the nucleus envelope (NE) by SUN proteins and is immobilised therein (PubMed:24667841). Mostly localized at the nuclear periphery and, to a lesser extent, in the nucleoplasm (PubMed:17873096). Localized on the condensing chromatin during prometaphase to anaphase, but transferred from the decondensing chromatin to the reassembling nuclear envelope during early telophase. Relocalized to the nuclear periphery during late telophase (PubMed:23396599).
Protein: RL7_GLUDA
Sequence: MADLTKLVDELSALTVLEAAELSKLLEEKWGVSAAAPVAVAAAPAAGAAAAPAEEQTEFTVVLAKAGDKKINVIKEIRGITGLGLKEAKDLVEGAPKTVKEGVNKDEAEKIKKLLEDNGASVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: COQ4_DROSI
Sequence: MMQRCLRLQKPLALRRGLHLAQVNSQAVATEAPEAEPLDAFERQYLKERIEISPFQRLFLGTGSSIAALLNPRRHDMIACLGETTGEDALWTILDTMQASEEGQRIMADKPRIHTSTIDFKYLETLPPDTFGAAYVKFLKDNQVTPDSRMAVRFLEDPKLAYLMTRYRECHDLIHTVLDMPTNMLGEVAVKWVEALNTGLPMCYGGAVFGAVRLRPKQRRAYLKHYLPWALENGKRAKPLMPVYWEKRWEQNIHELRSELGITVLNKA
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, Coenzyme Q biosynthesis protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RS3_RHIL3
Sequence: MGQKINPIGFRLGINRTWDSRWFADNAEYGQLLHEDLKMRKFVMSELKQAGISKVVIERPHKKCRVTIHSARPGLIIGRKGADIDKLRKKLSEMTNSETHLNIVEVRKPEVDATLVAQSIAQQLERRVAFRRAMKRAVQSAMRLGAEGIKITCAGRLGGAEIARTEWYREGRVPLHTLRADIDYGTAEAETAFGICGIKVWIFKGEILEHDPMASERRAMEGDAQGPASRDRDRDRDRRRDNA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RL4_MANSM
Sequence: MELQVVGANALAVSETTFGREFNEALIHQVVVAYAAGARQGSRAQKTRAEVSGSGKKPWRQKGTGRARSGDIKSPIWRSGGITFAAKPQDHSQKVNKKMYRGAIKSILSELVRQDRLVVVDKFEIDAPKTKVLVQKLKDLALEDVLIITASLDENLFLAARNLYKVDVRDVQGIDPVSLIAFNKVVVTVDAVKQIEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ACSL6_MOUSE
Sequence: MQTQEILRILRLPELSDLGQFFRSLSATTLVSVGALAAVLAYWLTHRPKALQPPCNLLKQSEEVEDGGGARRSVIGGCTQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPEQPYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFVGVFAQNRPEWIIAELACYTYSMVVVPLYDTLGPGSISYIINTADICTVIVDKPHKATLLLEHVERKETPGLKLVILMEPFEDALRERGKKCGVDIKSMQAIEDCGRENHHAPVPPRPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALRPTIFPVVPRLLNRMYDKIFHQADTSLKRWLLEFAAKRKQAEVRSGIIRNNSIWDELFFNKIQASLGGHVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDAEELNYWTCKGEGEICVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSEPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKKGIEGTYQELCMKKELKKAILDDMVMLGKESGLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYLVSV
What is the function of this protein?
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity).  Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid (By similarity).
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase 6, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 6, LACS 6.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: APR_HUMAN
Sequence: MPGKKARKNAQPSPARAPAELEVECATQLRRFGDKLNFRQKLLNLISKLFCSGT
What is the function of this protein?
Promotes activation of caspases and apoptosis.  Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria.  Contributes to p53/TP53-dependent apoptosis after radiation exposure.  Promotes proteasomal degradation of MCL1.  Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity).  Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
What are the official names of this protein?
Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa.
What is the protein family that this protein belongs to?
Belongs to the PMAIP1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AROC_STRPJ
Sequence: MRYLTAGESHGPRLTAIIEGIPAGLPLTAEDINGDLKRRQGGYGRGGRMKIESDQVVFTSGVRHGKTTGAPITMDVVNKDHQKWLDIMSAEDIEDRLKSKRKITHPRPGHADLVGGIKYRFDDLRNSLERSSARETTMRVAVGAVAKRLLAELDMEIANHVVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQIKRDGDTIGGVVETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGVEFGLGFEAGYRKGSQVMDEILWSKEDGYTRRTNNLGGFEGGMTNGQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKATVERSDPTALPAAGMVMEAVVATVLAQEILEKFSSDNLEELKEAVAKYRDYTKNY
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RDRP_I57A2
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVIESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRIYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICENLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFKSKSMKLRTQIPAEMLTSIDLKYFNESTRKKIEKIRPLLIDGTVSLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYTNRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESDDMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLISDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDQQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: NS2A_CVBLY
Sequence: MAVAYADKPNHFINFPLTQFEGFVLNYKGLQFQLLDEGVDCKIQTAPHISLAMLDIQPEDYRSVDVAIQEVIDDMHWGEGFQIKFDNPHILGRCIVLDVKGVEELHDDLVNYIRDKGCVADQSRKWIGHCTIAQLTNAALSIKENVDFINSMQFNYKITINPSSPARLEIVKLGAEKKDGFYETIVSHWMGIRFEYNPPTDKLAMIMGYCCLEVVRKELEEGDLPENDDDAWFKLSYHYENNSWFFRHVYRKSFYFRKSCQNLDCNCLGFYESSVEED
What are the official names of this protein?
Non-structural protein 2a, ns2a, 32 kDa accessory protein, 32 kDa non-structural protein, ns2.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses ns2a protein family.
Protein: SOTB_PSEA8
Sequence: MDSTSETRSGSWLSVIALALAAFIFNTTEFVPVGLLSDIGHSFEMPTSQVGLMLTIYAWVVSLASLPMMLLTRNIERRKLLVGVFLLFIASHVLSGLAWSFQVLMLSRIGIAFAHAVFWAITASLAVRVAPPGQQAKALGLLATGTTLAMVLGIPLGRVVGEALGWRTTFMAIAGLSVLTLLYLARSLPLLPSQNSGSLRSLPMLFRRPALVCLYVLTVVVISAQFTAYSYIEPFAKQVARMSGEATTLLLLLFGGAGIFGSILFSRYSEAFPRGFLLAAILALGSSLALLLPLSAQPTWLMALSLLWGMSIMCFGLAQQSRVLRLASDATDVAMALFSGLYNVGIGAGALLGSVVSERMGLASIGNVGAALALAGLLLALFAALRYAEALKSTSL
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: B78_SSV1
Sequence: MTDAISLALQTGLGPVVGVIIILAMMGLTYKIAGKIPAIITGIASAFVLMFMDFLPLFWGIAIIFGLIAGMVVTRDGD
What is the function of this protein?
This protein may be involved in virus assembly.  Essential for virus function.
What are the official names of this protein?
Uncharacterized protein B-78.
Protein: CYNS_ARATH
Sequence: MEAAKKQSVTNQLLAVKSASGKTFSQLAAETGLTNVYVAQLLRRQAQLKPDTVPKLKEALPALTDELIGDMMSPPWRSYDPNLIQEPTIYRLNEAVMHFGESIKEIINEDFGDGIMSAIDFYCSVDKIKGVDGNNRVVVTLDGKYLSHSEQRTENMVSRLNLKGGTSE
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: SPL1_ENCCU
Sequence: MILAIISLSVVICREVSDYIVMFDQDPSMDRASMKVLYNMNIHEAQNILRPDESIGIKMTNGFVARMSESTAERMKRHPSVKMVVKDSPVGISGLKFDVPGSDDRSGIVMQRHAPWGLARVGGSVSLVHGNYCYPINSGKGVDVYVLDTGVEIEHPEFGGRARWGANFVPKSPDRDEHGHGTHCAGVIGGKNFGVTKESSIIAVKVLDKYGSGMTSRLLQGVDFVIKEHEKKKDELYNAAADEYLSSGGSSDIEIEMDGSESFSFVQPETPSIQRLVDAISRKALQPKTVVNLSVGGFRNAALNFAIEYASRLGIHFSTAAGNEHEDACDFSPGSSRAAITTGASTYRDTVAFFSNFGKCVNVFAPGVDILSSWIGGTQKIVSGTSMAAPHTSGAIAAYLTYYDYDPHMLKSRIIGDARLIEDVSEDDYDGTTIWPLPSLFNANKKKLPILSMERLLRRVRNKMR
What is the function of this protein?
May be involved in the degradation of proteins for nutrient acquisition or possess a regulatory function by proteolytic activation of proproteins.
What are the official names of this protein?
Putative subtilisin-like proteinase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: TGT_RICB8
Sequence: MSKFSFNINHQYKKARSGIITTAHGNIRTPAFMPVGTRGTVKAMLPESVAETGADILLGNTYHLMLQPSAERIAKLGGLHKFMNWGKPILTDSGGFQVMSLSKLRKITEEGVSFNSHINGDKYLLTPERSTEIQHLLGSTITMAFDECTPYPATFEEAKTSMQLTTRWAHRSREAFVKRDGYAQFGIIQGSTYEELREQSAKDLIELDFEGYAIGGLAVGEGQELMFKVLDYAPDFLPQNKPRYLMGVGKPADIIGAVSRGVDMFDCVIPTRSGRNGQAFTKYGTVNIRNSKYAEDNDPLEADCLCPACQNYSKAYLHHLVRIGEILGAMLMTWHNLTYFQNLMSRIREYIALGKDFDFTT
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: CTX17_LACTA
Sequence: MKYFVVALALVAAFACIAESKPAESEHELAEVEEENELADLEDAVWLEHLADLSDLEEARGFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKHYGKKALQKASEKL
What is the function of this protein?
Insecticidal, cytolytic and antimicrobial peptide.  Has insecticidal activity against the flesh fly S. carnaria.  Has antibacterial activity against the Gram-negative bacteria E. coli.  Forms voltage-dependent, ion-permeable channels in membranes.  At high concentration causes cell membrane lysis.
What are the official names of this protein?
M-zodatoxin-Lt8f, M-ZDTX-Lt8f, Cytoinsectotoxin-1f, CIT-1f.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 06 (cytoinsectotoxin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: LOLB_YERPG
Sequence: MPMRKRHFYRLLPLASLLLAACTIPVSKGPATSPTSPQWRQHEQQLQQLGQFETRGAFAYLSDKQKVYARFFWQQTSPERYRLLLTNPLGSTELELVVQPGVTQLTDNQGKRYVSDDPQEMIQKLTGMSIPLESLRQWILGLPGDTSDFTLDDKYRLKKLTYQQNGVTWVVDYQEYNTQVTPSLPSRLELNQDGQRIKLKMDSWTIK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: MRAZ_PSEMY
Sequence: MFRGANAISLDAKGRLAMPSRYRDELVARCNGQLIVTIDAVDPCLCVYPLAEWELIENKLRELASFREENRRLQRLLIGNAVDLELDASGRFLVPPRLREYAKLDKRAMLVGQLNKFQLWDEDAWNAVAEADLAAIKQPGALSDDLRDLIL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: NU3C_PHAVU
Sequence: MFLLYEYDIFWAFLIISSLIPILAFLISGILAPISKGPEKLSSYESGIEPIGDAWLQFRIRYYMFALIFVVFDVETVFLYPWAMSFDVLGVSVFLEAFLFVLILIVGSVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RNH_CUPNH
Sequence: MQEVTIYSDGACKGNPGRGGWGAVLVAGASEKEMFGGEPNTTNNRMEMTAVIEALRALKRPCVVRVYTDSQYVQKGISEWLPGWKARGWKTADKKPVKNADLWQELDTLAQPHQISWHWVRGHNGHPGNERADALANRGVESIGR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTAD_PYRFU
Sequence: MIIKNGMIIYGDEFTIVRSDVLIEDGVIKEVGKNIRAPADMVIDASSHLVIPGLINAHTHVSMVLLRGLAEDVPLQEWLQNYIWPRERELKRKDIYWGTLLGLVEMARSGVTTFVDMYFHIEEVAKATIEVGLRGFLGYGMVDLENREKLEVEIKETEKFYEYVTKINSPLVNFVLAPHAPYTCSLECLKWVSKKANQWNVPVTIHLSETKKEVEEIRKKYGMTPTQLLDEVGLLNEKLIAAHGVWLSEEELRMLSSANATVVHCPASNMKLGSGVFPLRKALDLGVNVALGTDGAASNNTLDMLREMRLASLLQKVAHLNPAIVKSEEILKMATVNPAKALGLKSGVIKEGYIADLALINLRRPHLLPLNSPTSLLIYSARGGDVDTLFVNGEIVILDGEFLTVNEEKILDKFLKVIE
What is the function of this protein?
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively.  Is also able to deaminate adenosine.
What are the official names of this protein?
5-methylthioadenosine/S-adenosylhomocysteine deaminase, MTA/SAH deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Protein: NUOI_SHEON
Sequence: MKILRIIQGVGTQLRSLSMVFSHAWHPRETLNYPEEAVYAAPRYRGRIVLTRDPDGDERCVACNLCAVACPVGCISLQKSERDDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEYRRQDLVYEKEDLLISGPGKYPDYNFYRMSGMAIDGKPKGDAENEAKPIDVKSLLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.