PharMolix/UniProtQA huggingface dataset:
Protein: AT5G3_MOUSE
Sequence: MFACAKLARTPALIRAGSRVAYRPISASVLSRPETRTGEGSTVFNGAQNGVCQLIRREFQTSVISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
What are the official names of this protein?
ATP synthase F(0) complex subunit C3, mitochondrial, ATP synthase lipid-binding protein, ATP synthase membrane subunit c locus 3, ATP synthase proteolipid P3, ATPase protein 9, ATPase subunit c.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: MYG_THUOR
Sequence: MADFDAVLKCWGPVEADYTTIGGLVLTRLFKEHPETQKLFPKFAGIAQADIAGNAAVSAHGATVLKKLGELLKAKGSHAAILKPLANSHATKHKIPINNFKLISEVLVKVMHEKAGLDAGGQTALRNVMGIIIADLEANYKELGFSG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: STF3_MYCTO
Sequence: MKALRSSSRLSRWREWAAPLWVGCNFSAWMRLLIRNRFAVHHSRWHFAVLYTFLSMVNSCLGLWQKIVFGRRVAETVIADPPIFIVGHWRTGTTLLHELLVVDDRHTGPTGYECLAPHHFLLTEWFAPYVEFLVSKHRAMDNMDLSLHHPQEDEFVWCMQGLPSPYLTIAFPNRPPQYEEYLDLEQVAPRELEIWKRTLFRFVQQVYFRRRKTVILKNPTHSFRIKVLLEVFPQAKFIHIVRDPYVVYPSTIHLHKALYRIHGLQQPTFDGLDDKVVSTYVDLYRKLDEGRELVDPTRFYELRYEDLIGDPEGQLRRLYQHLGLGDFECYLPRLRQYLADHADYKTNSYQLTVEQRAIVDEHWGEIIDRYGYDRHTPEPARLRPAVGG
What is the function of this protein?
Involved in the biosynthesis of sulfomenaquinone (SMK, initially named S881 on the basis of its mass), which is localized in the outer envelope of M. tuberculosis and negatively regulates its virulence.  Catalyzes the transfer of a sulfonate group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to omega-hydroxy-beta-dihydromenaquinone-9, generating omega-sulfo-beta-dihydromenaquinone-9 (sulfomenaquinone).
What are the official names of this protein?
Omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase Stf3, PAPS-dependent sulfotransferase Stf3.
What is the protein family that this protein belongs to?
Belongs to the Stf3 family.
Protein: RF2_PSELT
Sequence: MITYETRVKIDELREKYLNFVKLIDPDKLNMELKKMESEMSDPEIWKDQRKAGEISKKVRRIKELLSDISEIERNFEDIDVGIELSEEDPGIAQDIEKIVQEVEKNIRRFQLELILNDPLDQNNAYLSIHPGAGGTESHDWAQMLLRMYMRWAERKGFIVELLDFQPGEEAGLKSATILVKGEYAYGYLKHERGVHRLVRISPFDAAKRRHTSFASVNVVPEISDDIDVEIKPEDIRIDTFRASGHGGQYVNRTDSAVRITHLPTGIVVSCQSERSQHQNKALAMKVLKAKLYQLELAKRREQLDEIQGELKEISWGNQIRSYILQPYTLVKDHRTDIETGNFDAVLDGELDQFIEAELLYFADYKI
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHI3_CANAL
Sequence: MLYLLTIFSLLLPALAINARSNSNVAVYWGQNSGGSQQRLSYYCDSDAVDIVILSFMHQFPSPIQLNFANACEGTYTANGILQCQTIAEDIKYCQNKGKTILLSLGGAAGSYGFSDDATAKQFAHTLWDLFGNSKNLATNDRPFYDAVLDGFDFDIENNWSTGYPALATELRTLFQKDTSKNYYLGAAPQCPYPDASVGPLLKQSEIDFVFIQFYNNYCNLGSSSFNWDTWLNYAETDSPNKNIKLFVGVPASSRAAGSGYNDPSAVSQYLTSDILNSKYFGGISMWDVSAGWSNTNSNGNFVENMKAIVKKASPGEETTSSSTTTTTTTTSTTISSSSSSSKTSKTSTTSTTSSSISSTTSSTTSSTSSSSTSSSTSSTTSSSTTSSQISTTSTAPTSSTSLSSSTISTSASTSDTTSVTSSETTPVVTPSSLSSAITIPGDSTTTGISKSSSTKPATSTTSALSSSTTTVATIPDDKEIINTPTDTETTSKPPAIITESDATTITQNLTPSTTTKNVKTTSTNIVTEWVWAPTTLRTLTTTYQILTTRTHIETVFAEPSTVVIYN
What is the function of this protein?
Chitinase involved in the remodeling of chitin in the fungal cell wall.  Plays a role in cell separation.
What are the official names of this protein?
Chitinase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYDP_CITK8
Sequence: MDELTSQALTAFTTRYCDAWHEKHNSWPLSEELYGVPSPCIISSTSDAVYWQPQPFEGEANVNAVESAFDIVIQSAVHAFYTTQFAGDMYAQFADEKLTLLQTWSADDFRRVQENLIGHLVTQKRLKLPPTLFIATLENELEVISVCNLSGEVCKETLGTRNRTVLAASLAEFLTQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: ADDA_BACVZ
Sequence: MMQIPKPKDSIWTDDQWSAIVSSGRDILVAAAAGSGKTAVLVERMIRKITAEEDPVDVDRLLVVTFTNASAAEMKHRIAEALEKELAKNPGSLHIRRQLSLLNRASISTLHSFCLQVLKKYYYMIDLDPGFRMADQTEGELLGDEVLDELFEDEYAKGNQAFFELADRYTTDRHDLDLQDLVKRVYEYSRSHPDPEVWLQSFVRLYDVTEESKMEELPFYQYVKEDAEMALFGAKQKLEKALELTKAPGGPAPRADNFLDDLQQIEELISCRHDFDALYERVPAVSFKRAKAVKGDEFDKALLDEATDLRNGAKKLIEKVKTDYFTRSPQDHLKSLADMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAVDEEGRRVPSEAAVYYQDQFHEVLVDEYQDTNLVQESILQLVKSGNEEAGNLFMVGDVKQSIYRFRLAEPLLFLGKYKRFTESGAGAGQKIDLNQNFRSRSDILDSTNFLFKQLMGGKIGEVDYDEQAALKLGASYPPNDAAKTELLLIDSADGADSSEDAEDFETVHWEAKAIAGEIRKLVSSPFKVYDGKTKTHRNIQYRDIVILLRSMPWAPQLMEELKNQGIPVYANLTSGYFEAVEVAAALSVLKVIDNPYQDIPLASVLRSPIVGCDENELALIRLEKKKAPFYEALKAYLANADRHDELYQKLRTFYDSLQKWRSFSTNHSVSELIWEVYRDTGYFDYAGGMPGGKQRQANLRVLYDRARSYEATAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKGLEFPVVFTAGLGRSFNMMDLNKSYLLDKELGFGTKYIHPELRISYPTLPLVAMKKKMRRELLSEELRVLYVALTRAKEKLFLVGSCKNREKQLAKWQAQADRADWLLSEFDRYQASSYLDFIGPALIRHRDMEAHRTPGLSSSEDIARDPSRFHIRMLQQSELLEENPKERAEEKSKRLKAIQQGEPIPDSFSFDDQARRLLEWEYPYRELTAIRTKQSVSELKRKQEYEDEYSGRSLIKPSGDTLLYRRPGFMMKKGLTAAEKGTAMHTVMQHIPLTHVPTAEEAERTVRMLYEKELLTEEQQEAIDIEEIVQFFGTEIGKDLLRALRIDREVPFSMALPAGEVYKDAETAGEPLLVQGIIDCLYETADGLYLLDYKTDRIEGKFRNGFEGAAPILQKRYETQIELYTKAVEQITKTKVKGRALYFFDGGHVLTL
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: RF1_THEON
Sequence: MSHKSAEMYELKKKVEELKSYRGRATELVSLYIPAGYDINKVMQQLREEYGTAQNIKSKSTRKNVLGALERAMQHLKLYRKTPENGLALFVGNVSEQEGVSDIKLWAIVPPEPLKVRLYRCDQTFVTEPLEEMLRVKDAYGLITVEKNEATIGLLRGKRIEVIDDLTSNVPGKTRAGGQSARRYERIREQETHEFMKRIAEHAAKAFLPLLEKGELKGIIIGGPGPTKEEFVDGDYLHHELRKKVIGVVDISYHGEYGLRELVEKASDILSEHEAVKERKLIQDFFRHLVKDTGLITYGEREVRKALELGAVDTLLISEGYDKVRVKAKCNACGWEELKTMSEQEFHVYKKKLTHCPKCGSQNISFEKWDVAEELIKLAEESGAEVEIISLDTEEGQQFYKAFGGLGAFLRYKIQ
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Peptide chain release factor subunit 1, Translation termination factor aRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE2_STAES
Sequence: MIPGEIIVKNTEIEVNKHHPETVIEVKNTGDRPIQVGSHFHFFEANKALEFDREKAYGKHLDIPAGAAVRFEPGDEKKVQLVEYSGRRKIYGFRGLVDGDIDEERVFRPNDSNQNAAVKNDAGEDNANKKGGK
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_GEOMG
Sequence: MARLNELYKNEIVPQLTKDFGYSNIMQVPKIEKIVVNMGLGEAIQNVKILDSAVEELAMITGQKSVITKAKKSIASFKLRQGMPIGCMVTLRREKMFEFLDRLINVALPRVRDFKGVSGKGFDGRGNYSLGIKEQLIFPEIEYDKIDKIKGLNITIVTSARSDEEGKALLKQLGMPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ACSA_VIBCH
Sequence: MSEAHIYPVKQNIKAHTHADNDTYLAMYQQSIKDPEGFWSEHGKIVDWIKPFTKVKHTSFDPGHIDIRWFEDGTLNVSANCIDRHLATRGDQVAIIWEGDDPTQDKTLTYKQLHQEVCRFANALKEQGVRKGDVVCIYMPMVPEAAVAMLACTRIGAVHTIVFGGFSPEALAGRIIDSNAKLVITADEGVRGGRAVPLKKNVDEALCNPEVKNISKVMVLKRTGGNVAWHEHRDIWWHEATAKASDNCPPEEMKAEDPLFILYTSGSTGKPKGVLHTTGGYLVYATMTFKYVFDYQPNEVFWCTADVGWITGHSYLVYGPLANGAKTILFEGVPNYPTTARMSEVVDKHKVNILYTAPTAIRALMAKGDEAIKGTSRDSLRIMGSVGEPINPEAWEWYYRTIGNEKSPIVDTWWQTETGGILITPLPGATALKPGSATRPFFGVQPALVDNMGEIVEGATEGNLVLLDSWPGQMRTVYGDHDRFEQTYFSTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFNKIAEAAVVGVPHDIKGQAIYAYITLNDGVYPSAELHKEVKDWVRKEIGAIATPDVLHWTDALPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDRLIAEKAQLK
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CYSD_BRUSU
Sequence: MKNLTHLQRLEAEAIHVFREVAATFSNPVMLYSVGKDSSVMLHLAMKAFYPAPPPFPFLHVDTTWKFREMIEFRDAQAREKGFELLVHVNEQGVRDGIGPFTHGSNVHTHIMKTVGLRQALDKYRFDAAFGGARRDEEKSRAKERIFSFRNAQHGWDPKNQRPEMWKIYNTRVSKGESIRVFPLSNWTELDIWQYILQENIPIVPLYFAARRPVVERDGMLIMVDDDRMKLRPGEQVENRLVRFRTLGCYPLTGAIPSSAANLSDIVEEMLIARTSERQGRAIDRDEAGSMEKKKREGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: RHG21_XENTR
Sequence: MATRRATVPEQQQQQPSSPGSEISKNKDGQEQSEMVSPTEEEGFCWPGPKSVALRRASEGFGFTLRHFIVYPPESAVHTTVKDEENGNRGVNAGRPRNRLEPMDTIFVKQVKEGGPAHEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDSTLELSVMPKDEDILQLAYSQDAYLKGNDSYSGNAQNIPEPPPICYPRTKPAASVMAQPVEVPPSGTSLTKQQSSRPVRTATTQPDRSYRVEIQVPPSPTDIVKSNTAVCVCNEAVRTVILPSEKVVDLSSNRTNRAGPLHRTEEVRYGLADPSMLKRTTSPPSSTPSVPMVPASRQFDNAGVIGKPPSYGGHSESMFSTRPSQAEESPSPTNHYASPGSHQQIDWRNYKTYKEYIDNRRMQMYGCRTIQERLDSLRAASQNTTDYDQMLPNRSSGQVRRRSTSHDRVPQSVQMRQRSVSQERLEDPVLMKEWPRSASQDTLTSLTVAPRNHRSESWDYLTRKEDFDQFIVDTQSNGEQKHNYKWTGFTEQDDQRGIYEIPRQHSFHMSLRSPNYTMAPLPYPSDSRRAGTRVLAPARPLQKVHPDLKTIQPTRNFQNSYRSPHPRPAVSERLVFPISKSNSVKIPATYASKPYSPSVGSEDGIVKDQKAVNYIHVSGPQNFQRKPQTESALGFQLDSLKTSTSASSSSPAHTKPAKQAKHSTATSQNVDGKKTQSPEANAGDSNSVLTSIDQVVLREKPSPGQQTSQPIRQPSYIFAVSDVEGASDTTCWLPNDARREVHIKRIEQKKASGSDSPGDSLASIPFIDEPTSPSIDHEIANIPASAVISISVQPLPTITTVPPSPTSPVPLIRRHFSHDHDSIRPSILEVNSKTERSKSCDEGLDDYKDEGKLSLKQGSSLKGIKARENVPSSEDSESRKDSSSDVFSDSNKEGFLYFRQLTTEKGKRVSGSMRPWKQMYVVLRGSALYLQKDKKEQSGHSSAQSDEEQLIGINGCLIDISYSETKRKNVFRLTTSDREFLFQAEDRDDMLAWIKAIQENGNLNDEQTDQASRVLISKRIKEYNTMMSSSSNKSEQSPKPSRQTLSIRQPFRATKPEGKLQSPHSPKQESERRLFSKDDISPPKDKGSWRRIMKKPFEKKPTTGGTFGVRLDDCPPAHNNKYVPLIVDVCCKLVEDRGLETTGIYRVPGNNAAISSMQEELNKGSTDIDIQDDKWRDLNVISSLLKSFFRKLPDPLFTNEKYNDFIEANRTEDPVERLKTLKRLILDLPDHHYETLKYLSAHLKAVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQQHDWFFSEESADEPITAVQEESTVESQPVPNIDHLLPNIGRTGLSPGDVSDSASDSAKSKGSWGSGKDQYSRELLVSSLFAAASRKRKKQRDKPQPSSSEDELDNVFYQKELLQVEFQRPDKQNVDKDVDLKANALSLKDADNIKGTNIIKEDKLEKDIMHSEATSPCPPKLSEPPIVNHRLPPDDKNIPQISFQMEESMSDSGTMLSTSSQASAQRSKPKVVSPELKGSDFLTADVSSITSDYSTTSSTIYIVGLDQNLISPEVQSVAESKGEEADDERSELISEGRPMETDSENDFPIFASSIAFDRQHRSKVEEPTRNVQVNSEGSPSCTEGSITPRMDRRRFSSHKLIECDTLSRKKSIRQKTDSECSAESKNEETLSDAQEAVKKGRSLSIGDTTTNNEPEEPAWRIKITERLKLRLKASADDMFGIGSQKAQAAETRKKKNIRRRHTLGGQRDFAEISVLNAWKINEPSSKEAELSAVDRLKPKCPSQDLSISDWLARERLRTSTSELSMVEPEEKRISDATSQKEPASPSPPPASSPSQVSTAIVTAGSESPSQGTAPPPDDQMNGDSFQSKNKNNFSPAVDAHPHKLSGTQVVRSRFYQYL
What is the function of this protein?
GTPase-activating protein (GAP) for rhoa and cdc42.
What are the official names of this protein?
Rho GTPase-activating protein 21, Rho-type GTPase-activating protein 21.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Protein: RL10L_HUMAN
Sequence: MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQLSSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS
What is the function of this protein?
Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity).  Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:12490704).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:32669547).  The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (By similarity).  It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (By similarity).
What are the official names of this protein?
60S ribosomal protein L10-like, Large ribosomal subunit protein uL16-like.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_MYCBP
Sequence: MSIEVANESGIDVSEAELVSVARFVIAKMDVNPCAELSMLLLDTAAMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPSMLGDIVLCPEFAAEQAAAAGHSLGHELALLTIHGVLHLLGYDHAEPDEEKEMFALQDRLLEEWVADQVEAYQHDRQDEKDRRLLDKSRYFDL
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH25H_RAT
Sequence: MACHNVSELQDLGCSNQLLLQPLWDSIRTGEASARSPFFPVIFSIFTYLGFCLPFVVLDVLCPWVPILRRYKIHPDFSPSVRQLLPCLGLTLYQHLVFVFPVTLMHWARSPALLPREAPELSQLLSHVLICLLLFDTEIFAWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSVWELLSLTFFDVLNVAMLQCHPLTILVFHVVNIWLSVEDHSGYDFPWSTHRLVPFGWYGGVAHHDLHHSQFNCNFAPYFTHWDKMLGTLRCAPHSKRLCAGSESCLDSGEQCTVHLNQKKKQT
What is the function of this protein?
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (By similarity).  Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity).  May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing.  As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses.  Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts virus-host membranes fusion which inhibits virus replication (By similarity).  In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (PubMed:11967195, PubMed:11207193).
What are the official names of this protein?
Cholesterol 25-hydroxylase, Cholesterol 25-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PIA1_PLEOS
Sequence: SAGKFIVIFKNDVSEDKIRETKDEVIAEGGTITNEYNMPGMKGFAGELTPQSLTKFQGLQGDLIDSIEEDGIVTTQ
What is the function of this protein?
Specifically inhibits an endogenous intracellular serine proteinase (proteinase A).
What are the official names of this protein?
Serine proteinase inhibitor IA-1, Proteinase A inhibitor 1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I9 family.
Protein: PROB_PSEPG
Sequence: MRSKVTGAKRWVVKIGSALLTADGKGLDRGAMAVWVEQMVALREAGVELVLVSSGAVAAGMSQLGWTTRPSAMNELQAAASLGQMRLVQAWESSFGEHGKHTAQILLTHDDLSDRKRYLNARSTLRTLVDLGVVPVINENDTVVTDEIRFGDNDTLAALVANLVEADLLVILTDRDGMFDADPRNNPEAQLIYEARADDPSLDAVAGGTGGALGRGGMQTKLRAARLAARSGAHTIIIGGRIERVLDRLKAGERLGTLLSPERGMLAARKQWLAGHLQTRGTLVLDAGAVQALRQANKSLLPVGVKTVQGSFRRGEMVVCVGPDGIEVARGLANYSALEAQKIIGQPSDAIESILGYSAEPELVHRDNLVLV
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_CERS4
Sequence: MLDQTNYTPRLKAAYANSVRAAMKEEFGYKNDMQIPRLDKIVLNMGVGEAVKDTKKVKTAAEELSMIAGQKAVVTHAKKSIAGFRVREQMPLGCKVTLRGDRMYEFLDRLITIALPRVRDFRGVKGNSFDGRGNYAMGLKEQFVFPEINFDKVDEVLGMDIIICTTAKTDAEAKALLKQFNMPFIS
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ASH2L_HUMAN
Sequence: MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
What is the function of this protein?
Transcriptional regulator (PubMed:12670868).  Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338).  Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245).  As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).  May play a role in hematopoiesis (PubMed:12670868).  In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
What are the official names of this protein?
Set1/Ash2 histone methyltransferase complex subunit ASH2, ASH2-like protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: BTNLA_MOUSE
Sequence: MARAHPGDATLPSILVSFIFLQLLTSGNGKSDFLVLGPPHPLLAIVGQDKELPCKLSLNISAEGMELRWYRDKPSSVVHVYKNGEDVYDEQMVEYKGRTSFNGSHVARGEAAVKIHNVTVFDNGTYHCVFKEYTSHSQATLWLKVAGRGSSPRIRVTDTQDKGIRAECTSAGWYPEPKVEWLDLKGQPVSAESHFSVSASTGLVALLSIVTPQDTAVGGLTCSISNPLLPEKDTGFLAAVVKVSVSGAHTGNIGQSVQSHGSIIKSSESFSVKVP
What are the official names of this protein?
Butyrophilin-like protein 10.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. BTN/MOG family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: BIOB_NITOC
Sequence: MTYFPPAAEICDSPRHDWSIPEVLALFELPFVELIYRAQTVHRQHFNPNQVQMSTLLSIKTGGCPEDCAYCPQSVRYSTPVKAEPLLPLEEVLTAARNAKARGASRFCMGAAWRRLKERELEPVAKMITEVKALGLETCVTLGMLGPGQAERLKAAGLDYYNHNLDTSPEFYGEIITTRTYQDRLETLSQVREAGIHVCCGGIVGMGEERSDRAGLLANLANLPRHPESVPINRLVQVEGTPLAGAPELDPFEFVRTVACARILMPASFVRLSAGRETMSDELQALCFLAGANSIFYGEKLLTTPNPTTDHDQQLFERLGLELLFPQAQVAAPVPEADEVGSASG
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.