PharMolix/UniProtQA huggingface dataset:
Protein: MDHC_BETVU
Sequence: MAVEPLRVLVTGAAGQIGYALVPMIARGVMLGANQPVILHMLDIPPAAEALNGVKMELVDAAFPLLKGVVATTDVAEACKGVNVAVMVGGFPRKEGMERKDVMPKNVSIYKSQASALEQYAAPNCKVLVVANPANTNALILKEFAPSIPEKNITCLTRLDHNRALGQISERLNAQVSDVKNVIIWGNHSSSQYPDVNPCTVKTGSGEKAVRELVADDAWLNGEFITTVQQRGAAIIKARKLSSALSAASSACDHIRDWVLGTPEGTWVSMGVYSDGSYNVPAGIIYSFPVTCKDGEWKIVQGLPIDEVSRQKMDATGAELVEEKALAYSCLT
What are the official names of this protein?
Malate dehydrogenase, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2B_METAC
Sequence: MVEVERVRYSDTLEREKIRAMIKARKEKQKEQSFENEKAVCPECGSRNLVHDYERAELVCGDCGLVIDADFVDEGPEWRAFDHDQRMKRSRVGAPMTYTIHDKGLSTMIDWRNRDSYGKSISSKNRAQLYRLRKWQRRIRVSNATERNLAFALSELDRMASALGLPRTVRETAAVVYRKAVDKNLIRGRSIEGVAAAALYAACRQCSVPRTLDEIEEVSRVSRKEIGRTYRFISRELALKLMPTSPIDYVPRFCSGLNLKGEVQSKSVEILRQASEKELTSGRGPTGVAAAAIYIASILCGERRTQREVADVAGVTEVTIRNRYKELAEELDIEIIL
What is the function of this protein?
Stabilizes TBP binding to an archaeal box-A promoter.  Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
What are the official names of this protein?
Transcription initiation factor IIB, TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
Protein: PYRD_HALSA
Sequence: MYGLLKSALFGLPPETTHEITTSALRVAQRVGAHRAYAKQFTVTDPRLSVDAFGQTFPNPVGMAAGFDKNAEIPRALAGLGFGHIEVGAVTAERQPGNDRPRLFRLPDDNALVNRMGFNNEGADTVGARLDAEPLPDVPVGVNIGKSKTTPLADAPDDYTYTFSRVGDAVDYVVVNVSSPNTPGLRELQGRDQLAAILEALQDAGASPLLVKLSPDLHQDAVADAVELANDLGLDGIVATNTTTERPESLSHPHAGEQGGLSGAPIRERATEQVRFVAERTDQPVVGVGGVATAEDAYEKIRAGASVVQLYTALVYEGPWVAKRINEGLVSLLERDGFDSVEDAVGADL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y4118_BACHK
Sequence: MEENQITIVDEKGNEHLCEIIFTFDAEKFGKKSYVVFSPIGEVDEDGDQIYDAMAYEQNEEEGGTLLPIESEEEWEMVQEMFNTLADEQEAE
What are the official names of this protein?
UPF0473 protein BT9727_4118.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: SEC23_NEUCR
Sequence: MDYEALKEQWGEVEDRDGVRLSWNVFPSTRMEASRLVVPIGALYTPLKEKPDTPLLQFDPVSCKQPCRSVLNPYCQVDVRARLWICPFCLSRNPLPPHYKDITANAIPPELHPSNTTIEYRLSRPAPAPPIFLYVVDTCQEEDSLAALKESLIMSLSLLPEHALVGLITYGTMAQVHEIGYTECPKSYVFRGNKEYAAKQVQEMLGLVQPAMRPGMPMQQPGRPFPAGPASRFLLPVSQAEFQLTKAIEQLQKDPWPVAGNLRALRCTGVALSVAVGLLETSFQNAGGRIMLFAGGPATEGPGMVVGPELREPIRSHHDIDRDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMKGLCNSTGGHMILTDSFTSSMFKQSFVRIFEKDADDNLLMGFNAVLEVLTTKELKVTGLIGHAVSLNKKSTSVGETECGIGNTCTWKMCGIDPSSSYGIYFEIANQGGPSQNMQSPQKGMMQFLTYYQHSSGHFHLRVTTIARNLSGPAGDPAIAQSFDQEAAAVLMSRIAVFKAEVDDGPDVLRWVDRMLIRLCARFADYRKDDPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVSNSLIMIQPTLDSYTFDQEGGVPVLLDSTSIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENFAALLEQPKEDARDLITDRFPLPRFIVCDQGGSQARFLLSKLNPSTTHTSGAGAYGGVGAQSAQTIFTDDVSLQTFMEHLMKLAVSGTN
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein sec23.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: WNT6_STRPU
Sequence: SGSCTLKTCWKKMPTFRDVGNRLKSYFDGAVKVTGGNSGENLIPEDETVKQPTIKDLVYSMESHDFCEPDRKSGSLGTEGRRCNSTSMDVGGCDIMCCGRGYHEVLAEKRENCRCRF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.
What are the official names of this protein?
Protein Wnt-6.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TAL_SYNFM
Sequence: MKFFIDTANLDEIKEAHSLGILDGVTTNPSLIAKEGIANREDFIRHIKTICELIQAPVSAEAVSTDAEKMIVEARSLAAIDPHVVVKIPMTIDGLKAVRQLSEEGIKTNVTLVFSPLQALMAAKAGATYISPFVGRLDDISADGMNLVEEILEIFSNYLFETEIIVASVRNPLHVLAAAKLGADIATIPFKVIDQLAHHPLTDLGVERFLKDWEKVEKQRV
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOE_STACT
Sequence: MKIQDYTKEMVDEKSFIDMAHTLLEEKGTTMNLYDIIDEFKALGHYEDDEHLENRIVQFYTDLNTDGRFLNVGENNWGLRDWYSVDDIEEKIAPTIQKFDILDEDDEEDKNLKLLGEEEEEIDDQETAEADAEDDDEDLDDPQDEEEINDSDIVIEEDKDEMDEAEQLFEEEEDFNDDPDDDKI
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: SDHF2_CANGA
Sequence: MLRITYKLPIALRQQAFVARKLVPTIKANYSTNSDDDVVSRIKVHPIKRINESIDKKRARLIYQSRKRGILETDLLLSGFAAKHLRSMTNEELDEYDALLNELDWDIYYWVTKNYKTSPVPERWKNSEILKKLQDFSENKEKKILRMPDLENY
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2, mitochondrial, SDH assembly factor 2, SDHAF2.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SH3R1_XENLA
Sequence: MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVSSRKELRCPECRTLVECGVDELPSNILLVRLLDGIRQRPRKAGDGGSAGNSTNALRAQGSVTTNGGLNDAQNTQSGQQRIQARSPPVRGVPQLPCAKALYNYEGKEPGDLKFNKGDIIVLRRQVDENWYHGEINGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFLKDDILTVIRRVDENWAEGMLGDKIGIFPISYVEFNSAAKQLIELDKPSGADTGEGSSGTSHSGNSQKQADAKKNTKKRHSFTSLTMSNKSSQSVQNRHSMEISPPVLISSSNPTAAARISELTGLSCSAPSQDMNPPLLPPPPMATPVITSASSGAAAVAQRNIIGPVEQVPHLRTSARPSVFIAIYPYIPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRALTTATPAKVAMATATTSNVVNLVTPTPPGAPCQKLPVSGVEFAKTSSTNGVSPAGVPGCHIQTSPQSKVLLHMSGQMTVNQARNAVRTAAAHSQDRPTAAVTPIQAQTPAASALPQQAAASQQVPPPLSAPAAYINAAMNISRPSVPAASAASSALPTAAFEAESSWKSSSGLSGCSFSENVSAPLNSAANKQDKDSKKEKKGLLKLLSGASTKRKPRSSPPHSPTQEVEQTNSEAAAALEGAVGPDIVPVIVNGRAAPCTVDCDSVSASTPAQDNRKPASLDNNIPIAPPPRQPCSSLGSVLNDSRPCERYRVMVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
What is the function of this protein?
Has E3 ubiquitin-protein ligase activity.  In the absence of an external substrate, it can catalyze self-ubiquitination.  Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway (By similarity).  Plays an essential role in the anterior neural development.
What are the official names of this protein?
E3 ubiquitin-protein ligase SH3RF1, Plenty of SH3s, Protein POSH, xPOSH, RING-type E3 ubiquitin transferase SH3RF1, SH3 domain-containing RING finger protein 1.
What is the protein family that this protein belongs to?
Belongs to the SH3RF family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell projection, lamellipodium. Golgi apparatus, trans-Golgi network.
Protein: SSPB_STAAW
Sequence: MNSSYKSRVFNIISIIMVSMLILSLGAFANNNKAKADSHSKQLEINVKSDKVPQKVKDLAQQQFAGYAKALDKQSNAKTGKYELGEAFKIYKFNGEEDNSYYYPVIKDGKIVYTLTLSPKNKDDLNKSKEDMNYSVKISNFIAKDLDQIKDKNSNITVLTDEKGFYFEEDGKVRLVKATPLPGNVKEKESAKTVSSKLKQELKNTVTPTKVEENEAIQEDQVQYENTLKNFKIREQQFDNSWCAGFSMAALLNATKNTDTYNAHDIMRTLYPEVSEQDLPNCSTFPNQMIEYGKSQGRDIHYQEGVPSYEQVDQLTKDNVGIMILAQSVSQNPNDPHLGHALAVVGNAKINDQEKLIYWNPWDTELSIQDADSSLLHLSFNRDYNWYGSMIGY
What is the function of this protein?
Cysteine protease that plays an important role in the inhibition of host innate immune response.  Degrades host elastin, fibrogen, fibronectin and kininogen.  Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner.  Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils.  Cleaves host galectin-3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin.
What are the official names of this protein?
Staphopain B, Staphylococcal cysteine proteinase B, Staphylopain B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C47 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MILR1_MOUSE
Sequence: MGDGDSPMCLSAVSFKGIRCWLDKLLLWALTISITLQNAAVDCTRVENNELPSPNLNSSMNVVRMGQNVSLSCSTKNTSVDITYSLFWGTKYLESKRRRGGAVDFHLRISNANESGPYKCKVNVSNLMKYSQDFNFTMAKDESCPSCRLSLLLPGLLLGILVIVLVLAYLIHLKYKKGKKTQREDQSKGSGDAPAQDELYVNACKTQTEQPQEIHYATPVFKEMAPMEEEGGTDGKADYIYSELTH
What is the function of this protein?
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells.  Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction.
What are the official names of this protein?
Allergin-1, Allergy inhibitory receptor 1, Mast cell antigen 32, MCA-32, Mast cell Ag-32, Mast cell immunoglobulin-like receptor 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: GRPE_BARQU
Sequence: MSDEKNKFTDASFENCDLKNPVDRDTLKKATDEFLKTHEAEIHSEVKEENNEVSDPLAALQDENKELKDQLLRLVADMENLRRRTARDVADAKAYSIANFARDMLSVSDNLNRALEAIPEGAKENDAGLKTLAEGVEMTERAMIAALERHGVQKIYPEGQKFDPHFHQAMFEIPNCDVPDNTVQQVVQAGYIIGERVLRPAIVGVAKGGTKGVPVESGSA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COFC_HALWD
Sequence: MHVIVPYTDVSPKTRLNSILTASERTAFAQAMLYDVISTLQSNGHTVELLIPTETVMQATDQRDQETIIDSTGVSTEAVSTSTSTHADTTEHNAASDNYVSQSPTHTLSVTPEAIMRILRDDDDPDNEASTQERDGDKEYIDITVDTAQNQIQSNQIVVTADDRALTPAVNSCLNRLSDTETPFSELAVVMADLALITPTAIERLFAREGDIVLAPGRGGGTNAIVVRHPAFRVDYHGTSYRDHYQAATDASLSVGVVDSMRLGTDIDKPTDLPEVLLHNNGMSSVWLQSAGIELNLDDNTGRVGITRKRKNEDVD
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: DXS_NEIMA
Sequence: MNPSPLLDLIDSPQDLRRLDKKQLPRLAGELRTFLLESVGQTGGHFASNLGAVELTVALHYVYNTPEDKLVWDVGHQSYPHKILTGRKNQMHTMRQYGGLAGFPKRCESEYDAFGVGHSSTSIGAALGMAAADKQLGSDRRSVAIIGDGAMTAGQAFEALNCAGDMDVDLLVVLNDNEMSISPNVGALPKYLASNVVRDMHGLLSTVKAQTGKVLDKIPGAMEFAQKVEHKIKTLAEEAEHAKQSLSLFENFGFRYTGPVDGHNVENLVDVLEDLRGRKGPQLLHVITKKGNGYKLAENDPVKYHAVANLPKESAAQMPSEKEPKPAAKPTYTQVFGKWLCDRAAADSRLVAITPAMREGSGLVEFEQRFPDRYFDVGIAEQHAVTFAGGLACEGMKPVVAIYSTFLQRAYDQLVHDIALQNLPVLFAVDRAGIVGADGPTHAGLYDLSFLRCIPNMIVAAPSDENECRLLLSTCYQADAPAAVRYPRGTGTGVPVSDGMETVEIGKGIIRREGEKTAFIAFGSMVAPALAVAGKLNATVADMRFVKPIDEELIVRLARSHDRIVTLEENAEQGGAGSAVLEVLAKHGICKPVLLLGVADTVTGHGDPKKLLDDLGLSAEAVERRVRAWLSDRDAAN
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RNPH_VIBVY
Sequence: MRPNDRAADQVRPIKITRNYTAYAEGSVLVEFGNTKVLCNATVEESVPRWLKGQGKGWVTAEYGMLPRATHSRTRREAANGKQGGRTMEIQRLIARSLRAVVDLEAMGEFMITVDCDVIQADGGTRTASISGASVAMADAFQHLVDSGKLKANPMKGHVAAVSVGILGEDVLCDLEYVEDSAADTDMNVVMTEEGKMIEIQGTAEGEPFSHEQLLALLESAKKGISEIVAAQKAALAN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RLMN_KINRD
Sequence: MTTPLDTPTREPLPLAPAGPGKLVMSAPRRGKPPRHFVDLEPAERGPAMVELGEKAFRGKQLATQWFERLEDDPARMTDLPAASRTRIAEALLPTLLTPIRTLTADGGTTIKSLYRLHDGALVESVLMRYKNRDTICISSQAGCGMNCPFCATGQAGLTRNLSTAEIVEQVTAASRALARDEVPGGPGRVSNVVFMGMGEALANYKSAVAAVRRLVSPAPDGLGISARGVTMSTVGLVPAIDKFAQEGIAATLALSLHAPDDELRDELVPINQRWKVGEALDAARRYFEATGRRVSIEYALIKDINDQAWRADRLGKLLNARGRGWVHVNPIPLNPTPGSKWTASDPAVERAFVAALENRGIPTTVRDTRGSDIDGACGQLAAIGPEQPRA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUAS_ASPUT
Sequence: MDAALRDICQLSDPCDPRSFEPPIKDFFCIYPMYRSRYEAKAIQGSNEFLDGWNKAIEKDGLRNDGRPFLGCNTIYGNYVAWAYPECLPERAAHVAAYCDWGFFWDDATDAMSMEKNHEATKDLILTIMSTVGIGQKHEPLLAVNKLVVPFVLNKLAGTDGDLGLNHMKAWKAHLDGQARSSHANMSWEELKQHRLVEGGPEWAIRLGAWGAGIRCTAEEIESVREIIDIGGIAGVLANDYYSFNKEFDEHSRAGTIERMQNGVALLMREYGYSEEEAREILKKEINKMEQQFMDMYLTWLNGPVQKSRGLIQYLTMVLCLYSGTMFWMAHGARYHRTDLITTAEDRATIIGKCQGDAFRVMEGYPPPKGLKRTASSPESAPKRRASKANNINQSNGRGGDPMVAFSGPFVKAPSHICDAPYEYIDSLQSKNMRDKFINILNSWLNVPSDSLQIIKNIVQMLHNSSLMLDDIEDASPLRRGQPATHIFYGASQTINSANFSYVKTVIEATHLKNPQCLQIFLEEVSDLHRGQSLDLHWRHHGRCPTTDEYIMMVDNKTGGLFRLMARLMEAESPSPITTPHLSRLLTLIGRYYQIRDDYMNLTSADYTTKKGYCEDLDEGKFSLPLIHLLLHTSCPDRITSALYNRVPSTGLQDEVKTYILDAMQSARTFEYVREVLSHLHGEIMKTLDEAEKTLGINNGVRMLLVGLGL
What is the function of this protein?
Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of aspergiltriene A, aspergildienes A-D and aspergilols A-D (PubMed:33480256).  The bifunctional terpene synthase AuAS converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into sesterterpenes (PubMed:33480256).  The C-terminal prenyltransferase (PT) domain of AuAS catalyzes formation of GFPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GFPP into 5 distinct sesterterpenes: aspergiltriene A, aspergildiene A, aspergildiene B, aspergildiene C and aspergildiene D (PubMed:33480256).  The cytochrome P450 monooxygenase AP450 then hydroxylates the aspergildienes A, B, C and D to yield the corresponding sesterterpene alcohols, aspergilols A-D (PubMed:33480256).
What are the official names of this protein?
Aspergildiene synthase, AS, Aspergilol biosynthesis cluster protein AuAS, Bifunctional terpene synthase AuAS, BFTS AuAS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the FPP/GGPP synthase family.
Protein: KCY_LIMF3
Sequence: MVKGIQVAIDGPASAGKSTVAKLVAKRFGYIYCDTGAMYRSVTLAALERGIDLSQDDLVSELANQITITFAPGDPQKVFIDGHEVTQAIRSTEVAQHVSTVAAIPAVRSRMVELQRQIAQEGGIVMDGRDIGTTVLPDAPVKIFMVASAHERARRRFLDNQERGIDGGSIEELQRAIELRDQKDSTRAVSPLVKAADAYQLDTTHLTIEQVVDQIAGRIEKTLKQK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DADA_XANC8
Sequence: MRVLILGSGVIGTTTAWYLAQSGCEVTVVDRQPASGLETSYANAGQLSFGYTSPWAAPGVPGKAVKWLFEQHAPLSIRPTRDLRQLAWLSQMLRNCTAERYAVNKARMVRLSDYSRDCLNALRASTGLEFEGRQLGTTQLFRTQQQLDAAAQDIEVLAQYGVPYELLSPAQIAQYEPGLAGGGAQMAGALHLPEDQTGDCRLFTQRLADLATQAGVQFRYGQQIERLEHAGGEITGVQIDGRLVTADRYVLALGSYSADLLLSLGLHLPVYPLKGYSLTIPIVDAQRAPTSTVLDESYKIALTRFDERIRVGGMAEVAGFDLSLNPRRRATLEMVVNDLFPGAGDLAQAEFWTGLRPATPDGTPVVGATPYANLFLNTGHGTLGWTMACGSGRYLADLMQGRTPEIDTEGLDVFRYLSTRSTRPHREAA
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: ATPF1_MARMS
Sequence: MLIDWFTVIAQLINFLVLVWLLKHFLYRPILNTIDAREKRIADELADADSKIAEAEQQREAFQQKNAEFDQQRTAQMNKVGEEAKAERTRLLEEVRQESDALRSKLKLALKNEQLSLKDSLSQRAREEVFAIVRKALSDLASTSLEASMADVFVKRLDALADAEKTSLQATFQESTEVLIVHTAFDLPKKQITQITKALHGLLGDGVVIEFATDANLISGIEIDSHGQKIGWSIADYLTTLTKRVNDVMLSHNAVQDESPELEKSQEQAS
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b 1, ATP synthase F(0) sector subunit b 1, ATPase subunit I 1, F-type ATPase subunit b 1, F-ATPase subunit b 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TSAC_PSEF5
Sequence: MVSSWRVQQAAREIRAGAVIAYPTEAVWGLGCDPWNEEAVDRLLAIKSRSVDKGLILIADNIHQFDFLFEDFPDTWIDRMSSTWPGPNTWLVPHQNLLPEWVTGVHDTVALRVSDHPLVRELCSLVGPLISTSANPQGRPAARTRLRIEQYFRGQLDLVLSGSLGGRKNPSLIRDLATGKVVRPS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECCD1_MYCTU
Sequence: MSAPAVAAGPTAAGATAARPATTRVTILTGRRMTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF
What is the function of this protein?
Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
What are the official names of this protein?
ESX-1 secretion system protein EccD1, ESX conserved component D1, Snm4 secretory protein, Type VII secretion system protein EccD1, T7SS protein EccD1.
What is the protein family that this protein belongs to?
Belongs to the EccD/Snm4 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NHAA_WOLSU
Sequence: MAENQDYASGNGGIKALLLNFIHSQSFSGIFLFFCAVVAMISANSALSESYFHLWHTEIGFFIGETFIGMSLHHWINDVLMSFFFLMVGLEIKRELLFGELAGIKRAAFPAIAALGGMIVPAIVYTLFNFGTDSAHGFGIPMATDIAFALGVLLLLGDKVSLALKVFLVSLAVVDDLGAVVVIAIFYTEDLQTLWLLYSVVILGLLIGLNKMGVRSLFPYAILGVLLWITVHNCGIHATIAAVALAFTIPVKPKIESENFAQEAKELLERFLSHDKERANLLLASEQVHSVELLSKHSKSVQSPLVRLEHALHPWSAYFIMPVFAFANAGVAISSNIHFDIDGVLPGIMLGLIVGKPVGILGLTYLAEKMGIATRPEGVMWIDILGAGMLAGIGFTMSIFITNLAFTNPEATDVAKIAILSASLFAGALGYFFISIRCRFKKKKEACCTIKS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SOTB_ECOLI
Sequence: MTTNTVSRKVAWLRVVTLAVAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGIMLTIYAWVVALMSLPFMLMTSQVERRKLLICLFVVFIASHVLSFLSWSFTVLVISRIGVAFAHAIFWSITASLAIRMAPAGKRAQALSLIATGTALAMVLGLPLGRIVGQYFGWRMTFFAIGIGALITLLCLIKLLPLLPSEHSGSLKSLPLLFRRPALMSIYLLTVVVVTAHYTAYSYIEPFVQNIAGFSANFATALLLLLGGAGIIGSVIFGKLGNQYASALVSTAIALLLVCLALLLPAANSEIHLGVLSIFWGIAMMIIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSMIGYVGAVPAFAALIWSIIIFRRWPVTLEEQTQ
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.  Transports L-arabinose and to a lesser extent IPTG.  Seems to contribute to the control of the arabinose regulon.
What are the official names of this protein?
Sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.