PharMolix/UniProtQA huggingface dataset:
Protein: MTDH_ALTAL
Sequence: MPISVPQATELKDLFSLKGKVVIVTGASGPTGIGTEAARGCAEYGADLAITYNSRAEGAEKNAKEMSEKYGVKVKAYKCQVNEYAQCEKLVQDVIKDFGKVDVFIANAGKTADNGILDATVEQWNEVIQTDLTGTFNCARAVGLHFRERKTGSLVITSSMSGHIANFPQEQASYNVAKAGCIHLAKSLANEWRDFARVNSISPGYIDTGLSDFVPQDIQKLWHSMIPMGRDAKATELKGAYVYFASDASSYCTGSDLLIDGGYCVR
What are the official names of this protein?
NADP-dependent mannitol dehydrogenase, MtDH, Mannitol 2-dehydrogenase [NADP(+)].
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Vacuole.
Protein: MCA1_YEAS7
Sequence: MYPGSGRYTYNNAGGNNGYQRPMAPPPNQQYGQQYGQQYEQQYGQQYGQQNDQQFSQQYAPPPGPPPMAYNRPVYPPPQFQQEQAKAQLSNGYNNPNVNASNMYGPPQNMSLPPPQTQTIQGTDQPYQYSQCTGRRKALIIGINYIGSKNQLRGCINDAHNIFNFLTNGYGYSSDDIVILTDDQNDLVRVPTRANMIRAMQWLVKDAQPNDSLFLHYSGHGGQTEDLDGDEEDGMDDVIYPVDFETQGPIIDDEMHDIMVKPLQQGVRLTALFDSCHSGTVLDLPYTYSTKGIIKEPNIWKDVGQDGLQAAISYATGNRAALIGSLGSIFKTVKGGMGNNVDRERVRQIKFSAADVVMLSGSKDNQTSADAVEDGQNTGAMSHAFIKVMTLQPQQSYLSLLQNMRKELAGKYSQKPQLSSSHPIDVNLQFIM
What is the function of this protein?
Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging.  Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells.  Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa (By similarity).
What are the official names of this protein?
Metacaspase-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NRFA_ECOSM
Sequence: MTRIKINARRIFSLLIPFFFFTSVHAEQTAAPAKPVTVEAKNETFAPQHPDQYLSWKATSEQSERVDALAEDPRLVILWAGYPFSRDYNKPRGHAFAVTDVRETLRTGAPKNAEDGPLPMACWSCKSPDVARLIQKDGEDGYFHGKWARGGPEIVNNLGCADCHNTASPEFAKGKPELTLSRPYAARAMEAIGKPFEKAGRFDQQSMVCGQCHVEYYFDGKNKAVKFPWDDGMKVENMEQYYDKIAFSDWTNSLSKTPMLKAQHPEYETWTAGIHGKNNVTCIDCHMPKVQNAEGKLYTDHKIGNPFDNFAQTCANCHTQDKAALQKVVAERKQSINDLKIKVEDQLVHAHFEAKAALDAGATEAEMKPIQDDIRHAQWRWDLAIASHGIHMHAPEEGLRMLGTAMDKAADARTKLARLLATKGITHEIQIPDISTKEKAQQAIGLNMEQIKAEKQDFIKTVIPQWEEQARKNGLLSQ
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ANXD7_ARATH
Sequence: MASLKVPATVPLPEEDAEQLYKAFKGWGTNERMIISILAHRNATQRSFIRAVYAANYNKDLLKELDRELSGDFERAVMLWTFEPAERDAYLAKESTKMFTKNNWVLVEIACTRSALELFNAKQAYQARYKTSLEEDVAYHTSGDIRKLLVPLVSTFRYDGDEVNMTLARSEAKILHEKIKEKAYADDDLIRILTTRSKAQISATLNHYKNNFGTSMSKYLKEDSENEYIQLLKAVIKCLTYPEKYFEKVLRQAINKLGTDEWGLTRVVTTRAEFDMERIKEEYIRRNSVPLDRAIAKDTHGDYEDILLALLGHDHA
What are the official names of this protein?
Annexin D7, AnnAt7.
What is the protein family that this protein belongs to?
Belongs to the annexin (TC 1.A.31.1) family.
Protein: SSH4_DEBHA
Sequence: MDPAIILFVFIFVSVCFCLLIFLSAYRVFSGGSERNEYSFLGSEILGSEVPREFLNDEEALNHLASEYDFTHLSPEEQFSYLRGEEFTKTNPPNFHNTRGKSYSNEDDMLLKERGINAFEFEQDADILRGRYIVADKTEINFHNNDTPYSTATSILNYSLPVKNRAYSDTVYFEVKVFEFQNGSENPNGHFAIGLVTKPYPSDFRLPGYNNFSIAYESTGNLKINKPFPTPLQQHQGDNSQYNALVLPPLQQSDIVGFGYVVSTGTLFITRNGKKVMDVMRGCFIDLYPAVGCFSSNAKFQVNLGQLGFVWIEANVRKYGFVSNSDYKKIKGEQGLAALPEYGNSSVAEGDKLLEMGEELPPRYPEDELDFFGRSSKDILKVGSSSKSQNKTKSFSNNEKQDLEEINGEPKVAEEHRSSLITDDPEEVMDLRERLYEQNITGPVSELSSERAPLIGNNESQSEFYVNAKSATSSREGNTETDLKQVTDEEPNSSQELTKAAQNDSNISKTSRTKKKKKNKKNSKKNKKK
What is the function of this protein?
Components of the endosome-vacuole trafficking pathway that regulates nutrient transport.  May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
What are the official names of this protein?
Protein SSH4.
What is the protein family that this protein belongs to?
Belongs to the SSH4 family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Protein: FAR9_ASCSU
Sequence: GLGPRPLRF
What are the official names of this protein?
FMRFamide-like neuropeptide AF9.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RACA_BACAC
Sequence: MEYKTPFIAKKLGVSPKAVVRIAQQLNLTIEKNKYGHFIFTQDDLDQMLEYHRSQIEQSQNTHPTQKTSSNDVEELKTQVNTIVQNISSHDFEQLAAQLNTITRRLDRMEEQMQDKANDVVTYQLLQHRREMEEMLERIQKLEAGLKKEEPIYITPDTKPTYEREKKPKRRKMIFSIFGL
What is the function of this protein?
Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore.  Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure.
What are the official names of this protein?
Chromosome-anchoring protein RacA.
What is the protein family that this protein belongs to?
Belongs to the RacA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cell poles and nucleoid.
Protein: ISPE_LEPBA
Sequence: MVLLQTIAHAKINIGLMIPYKREDGLHEIRSVFVPIDFGDPMEIQIKSLPKGIVSRFVFHSTNHLQGYRHSLFEAVSERGDLSQNILTKTFHKLKPYFQEALEIKVQIQKHLPPEGGIGGGSSNAGVLLQHLFPYTNLSRGEQIQFAKSIGADVPFFLQSSACFVTGIGEVMEPIRLAKGFGILAIPPFGLSTGSMYASLQKSLQKPYGSEVWKSLTEDLIRSLHVGDWVYLQNRLENEFEKIAFQTQPLLKELKLGFFESGAIFASLSGSGSCLYGIYPTEEKRNEALPNVSLRFPKMEFRTFSF
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PRMA_THENN
Sequence: MRFKELVFLLKIDEEELLEKLYEEGFFNFAIEENKEGDRLLRVYLREGETLPSFLSNWKILDERLTTPKDWMVELEPFEIVEDVVVDPTEKVTRTDKIVVKLSPGVAFGTGLHPTTQMSVFFLKKYLKKGDRVVDVGCGTGILAIVAKKLGASYVMAVDVDEQAVEVAKENVQKNSVDVIVKRSDLLSEVDGVFDLVVSNILAEIHLRLLEDVDRITHERSILILSGIVDTKENMVREKASKKGWNLLERKQEREWVTLVMKRS
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIM12_XENTR
Sequence: MWPVLWAAARTYAPYITFPVAFVVGAVGYQLEWFIRGTPEQPVEELSILEKREERTLQETMGKDVTQVLSLKEKLEFTPKAVLNRNRQEKS
What are the official names of this protein?
Small integral membrane protein 12.
What is the protein family that this protein belongs to?
Belongs to the SMIM12 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LYTE_BACSU
Sequence: MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYDTTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKKYGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLSKIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSLNVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSIASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF
What is the function of this protein?
Cell wall hydrolase that cleaves gamma-D-glutamate-meso-diaminopimelate bonds in peptidoglycan (By similarity).  Seems to play a role in cell separation during vegetative growth.
What are the official names of this protein?
Probable peptidoglycan endopeptidase LytE, Cell wall-associated polypeptide CWBP33, Gamma-D-glutamate-meso-diaminopimelate muropeptidase LytE, Minor autolysin LytE, Phosphatase-associated protein PapQ, Vegetative cell wall hydrolase LytE.
What is the protein family that this protein belongs to?
Belongs to the peptidase C40 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=LytE is localized at cell separation sites and cell poles of vegetative cells.
Protein: MOAC_STRGG
Sequence: MTGAPSARRSELSTQNRLTHIDETGAARMVDVSQKDVTTRLARASGRVLVSPRVIELLRGEGVPKGDALATARIAGIMGAKRTPDLIPLCHPLAVSGVEVELGVADDAVEITATVKTTDRTGVEMEALTAVSVAALTVIDMVKAVDKSAVITDVRVEAKSGGKSGDYRRTAPEGPDA
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: CP18D_ARATH
Sequence: MSNPRVFFDMSLSGTPIGRIEMELFADTTPNTAENFRALCTGEKGMGKLGKPLHFKGSIFHRVIPGFMCQGGDFTAKNGTGGESIYGAKFKDENFIKKHTGAGILSMANSGPNTNGSQFFICTDKTSWLDGKHVVFGQVVKGLDVVKAIEKVGSDSGKTSKVVTITDCGQLS
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase CYP18-4, PPIase CYP18-4, Cyclophilin of 18 kDa 4, Cyclophilin-1, Rotamase cyclophilin-5.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAX2A_XENLA
Sequence: MFDQATSMGDGVSEERSPLCGKSATSCSERVRDKGTRADLECSLRGHSLKDIPVTSTSSPGSSKEEVQDSQSTGEADYCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLELEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQSRDSEKRSSSTSESFATCNILRLLEQGRLLSVPAPPNLISSSQNNMGTSSGNGTNLGTSGSTSPIISTTPPGAGAFSLQVPSLAASSSPRLPTSLCFPGPLLGGLHEIPSGYGLGSSAFEPYTRLDRKDTASSKKSTS
What is the function of this protein?
Transcription factor that may function in dorsoventral specification of the forebrain.  Regulates the expression of Wnt signaling antagonists including the expression of a truncated tcf7l2 isoform that cannot bind ctnnb1 and acts therefore as a potent dominant-negative Wnt antagonist.  Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle.  May be a regulator of axial polarization in the retina.
What are the official names of this protein?
Ventral anterior homeobox 2a, Xvax2.
What is the protein family that this protein belongs to?
Belongs to the EMX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MED10_YARLI
Sequence: MAEAARQELENQLRQTIETLVEISLLVHDTTGSQENKEGLIEQMDTLVKEFQRLKEIKCDKQIPIDVIDYIDQGRNPDVYTREFVELLLKQNQFIHGKMDIYTVSKGVRESTSDDIPLDISCGAHSNTEISTNPGQKRQGNVS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 10, Mediator complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VGF_RABPU
Sequence: MSMKYLMLLFAAMIIRSFADSGNAIETTLPEITNATTDIPAIRLCGPEGDGYCLHGDCIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIVLVLVGIIMCCLLSVYRFTRRTKLPIQDMVVP
What is the function of this protein?
Stimulates cellular proliferation (hyperplasia)and mobility around infected cells to promote rapid and efficient spread of infection.
What are the official names of this protein?
Growth factor, Secreted epidermal growth factor-like.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG019 family.
Protein: ASSY_BRASO
Sequence: MTTILKGLPTGEKVGIAFSGGLDTSAALLWMKQKGARCFAYTANLGQPDESDYDEIPRKAMSFGAEKARLVDCRTQLVHEGIAAIQSGAFHISTGGATYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNPNLKIYKPWLDQQFIDELGGRAEMSAFLTAHGFNYKMSAEKAYSTDSNLLGATHEAKDLESLSSGIRIVNPIMGVPFWREDCAVRPETVVVRFEEGQPVALNGQTFTDPVALFLEANAIGGRHGLGMCDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQYRMSGMKLGRLLYQGRWFDSQALMLRETAQRWVASAITGEVTLELRRGNDYSLLNTESPNLTYQPERLSMEKVEDAAFTPADRIGQLTMRNLDITDTRTKLKLYSDTGLLSGAEGAQIFQLGHDKGDKS
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT8B4_HUMAN
Sequence: MFCSEKKLREVERIVKANDREYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQLIPEISSLTWFTTIVPLVLVITMTAVKDATDDYFRHKSDNQVNNRQSEVLINSKLQNEKWMNVKVGDIIKLENNQFVAADLLLLSSSEPHGLCYVETAELDGETNLKVRHALSVTSELGADISRLAGFDGIVVCEVPNNKLDKFMGILSWKDSKHSLNNEKIILRGCILRNTSWCFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLICLGIILAIGNSIWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDDLDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVHEFLRLLALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTLVTYQLLAFLDFNNTRKRMSVIVRNPEGQIKLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGATAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQNLFGQNRNFSNGHVVCEKKQQLELDSIVEETITGDYALIINGHSLAHALESDVKNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQEGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIAIYFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPTLSDQIRRWQKAQKKARPPSSRRPRTRRSSSRRSGYAFAHQEGYGELITSGKNMRAKNPPPTSGLEKTHYNSTSWIENLCKKTTDTVSSFSQDKTVKL
What is the function of this protein?
Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids.  Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).
What are the official names of this protein?
Probable phospholipid-transporting ATPase IM, ATPase class I type 8B member 4, P4-ATPase flippase complex alpha subunit ATP8B4.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus.
Protein: FENR1_ALKCK
Sequence: MQEKEMFDLTIIGGGPAGLYSTFYAGMRDLKVKLVEYNKELGGKILFYPEKIIWDVGGMPPTTGRTLINQLVEQATTFNPTICLNEHIVRMVREPDNTYTLFNEQGKAHYTRAVMLASGHGIPVMQKLEIEGADRYEVSNLHYTVTQMDIFANKRVLISGGGNAAVDWANELANISKEVVVCHRRDEFGGHEKNVEQMKSVTKIHTPYQIKELHGVGSAIEAVTLAHCDTGEQRQIEVDAVIVNHGMKLDGCFLIEAGLALEEDGFLRVSACMETSQPGIFAAGDVTRHEGKLQLISGAFVEGATAVNGVKQFLDPKADKQAYVSSHNEKFKKKNEQLKQEKQAQLMN
What are the official names of this protein?
Ferredoxin--NADP reductase 1, FNR 1, Fd-NADP(+) reductase 1.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: VE1_HPV5B
Sequence: MTDPNPKGSTSKEGFGDWCLLEADCSDVENDLGQLFERDTDSDISDLLDDTELEQGNSLELFHQQECEQSEEQLQKLKRKYLSPKAIAQLSPRLESISLSPQQKSKRRLFAEQDSGLELTLNNEAEDVTPEVEVPAIDSRPDDEGGSGDVDIHYTSLLRSSNKKATLMAKFKESFGVGFNELTRQFKSHKTCCKDWVVSVYAVHDDLFESSKQLLQQHCDYIWVRGIGAMSLYLLCFKAGKNRGTVHKLITSMLNVHEQQILSEPPKLRNTAAALFWYKGCMGSGAFSHGPYPDWIAQQTILGHKSAEASTFDFSAMVQWAFDNHLLDEPDIAYQYARLAPEDANAVAWLAHNNQAKFVRECAAMVRFYKKGQMRDMSISEWIYTKINEVEGEGHWSDIVKFIRYQNINFIVFLTALKEFLHSVPKKNCILIYGPPNSGKSSFAMSLIRVLKGRVLSFVNSKSQFWLQPLSECKIALLDDVTDPCWVYMDTYLRNGLDGHYVSLDCKYRAPTQMKFPPLLLTSNINVHGEANYRYLHSRIRGFEFPNPFPMKADNTPQFELTDQSWKSFFTRLWTQLDLSDQEEEGEDGESQRAFQCSARSANEHL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: CRCB3_BRUAB
Sequence: MRNWRQAENIRLYIAVGCGAAIGALLRFLSGWVIVAILGANPLWGTSFVNIVGSFIIMFFATLTGPEGRWLVSPAWRQFVMGGLCGGLTTFSSMSLDTFLLVLHGNAAFALAYLCGLVFLSLSAAMLGLIAAQRINR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 3.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PCP_THELN
Sequence: MKKVLITGFEPFGGDSKNPTEQIAKYFDRKQIGNAMVYGRVLPVSVKRATIELKRYLEEIKPEIVINLGLAPTYSNITVERIAVNIIDARIPDNDGYQPIDEKIEEDAPLAYMATLPVRAITKTLRDNGIPATISYSAGTYLCNYVMFKTLHFSKIEGYPLKAGFIHVPYTPDQVVNKFFLLGKNTPSMCLEAEIKAIELAVKVSLDYLEKDRDDIKIPL
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FA32A_BOVIN
Sequence: MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK
What is the function of this protein?
May induce G2 arrest and apoptosis.  May also increase cell sensitivity to apoptotic stimuli.
What are the official names of this protein?
Protein FAM32A, Ovarian tumor associated gene 12, OTAG-12.
What is the protein family that this protein belongs to?
Belongs to the FAM32 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GAG2B_HUMAN
Sequence: MSWRGRSTYRPRPRRYVEPPEMIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGEDEGASAGQGPKPEAHSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEKQSQC
What is the function of this protein?
Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.
What are the official names of this protein?
G antigen 2B/2C, GAGE-2B, GAGE-2C, Cancer/testis antigen 4.2, CT4.2, G antigen 2C.
What is the protein family that this protein belongs to?
Belongs to the GAGE family.
Protein: FIEF_ECOSM
Sequence: MNQSYGRLVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNLLVVRYSLQPADDNHSFGHGKAESLAALAQSMFISGSALFLFLTGIQHLVSPTPMTDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHYQSDVMMNGAILLALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDEERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDSLPLVQAHMVADQVEQAILRRFPGSDVIIHQDPCSVVPREGKRSMLS
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS1_ORYSJ
Sequence: MSPMLATLPDVTAVLHSPSASPPSGLRAPAAVGMGMARTRFLAPRAAASAASAVSAKPAAVAPLYADRTVVRIGLPSKGRMSEQTLSLLKSCQLSVRHLNPRQYTADIPQVPNLEVWFQRPKDIVRKLQSGDLDLGIVGFDIVSEYGQGSDDLVVVHDALEFGHCRLSLAVPKEGIFENINTLEDLANMPEWTQERPLRVVTGFGYLGEKFMRENGFNHVSFLAGDGALESYPAMGMADVIVDLVSSGTTLRENNLKEIDGGVVLESQATLVACRRSLHKRNGVLEITHEMLERLEAHLTATGEIMVTANMRGNSAEEVAERVLSQTSLCGLQGPTISPVYRSRDGKVAVEYYAINVVVPQKSLYKSIQQLRSIGGSGVLVTKLTYIFDEETPRWRKLLSELGL
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).
What are the official names of this protein?
ATP phosphoribosyltransferase, chloroplastic, ATP-PRTase, AtATP-PRT.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACYP_SULAC
Sequence: MGGLKRMYVIVYGIVQGVGYRRFIQIHAARLGIKGYAKNLPDGSVEILAEGYEEALYKLLDQIKRGPPLSKVEKVDVKFDDYTGEFASFDTY
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: TIG_BURP1
Sequence: MANVVENLGKLERRVTISLPKDVVQKEIDARIQKLAKNVRMPGFRPGKVPLKMVAQQYAGQVEAEVLSDKIGQEFFTISRAENLRVAGQPSFAPKEDTQQESTYAFDATFEVYPEVKIGDLATAEVERSTTTIGDAEIDRTLDILRKQRVHFHARGEGGEHGDGGADTAAQNGDRVTVDFVGKIDGVAFQGGTAEDFVFVLGEGRMLPEFETAALGLKAGESREFDLKFPDDYHGKDVAGKTAQFTVTLKKVEWPHLPEIDADFAKSLGVEDGDLTKMRAEIKENLEREAKRRTQSIVKNQVMDALLKISELDVPKALIEQDQQRLVEMARQDLAQRGVPNAKDAPIPAEMFADQAERRVKLGLVLAELVKANGLEAKPEQIRAEVDEFAKSYEDPKEVVRWYYSNQQRLAEMEAFVVESNVVDFVLGKAKVTDKEVSFEALASATAQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: DAPE_XANAC
Sequence: MSDVLELTCDLIARASITPADAGCQAAIAQRLRAAGFSCEHLRLGEVENLWATHGSGAPVLVLLGHTDVVPPGPREAWTSAPFDPQIRDGVLYGRGAADMKGSVAAFVVAAEQFVAAHPSHTGTLAVLLTSDEEGDAIDGVRRVAEVFRERGQTIDWCITGEPSSTERLGDLLRVGRRGSLSGTLTVKGVQGHVAYPHKARNPIHLAAPALAELVARQWDDGFESFPPTSLQLSNIHAGTGANNVIPGELQVAFNLRYTPHWDAPRLEAEITALLDRHALDYALRWHRSGEPFYTPEGRLRSVAREVLGEFAGAPPEESTGGGTSDARFIAPLGAQCIEVGPVNASIHQVDEHVRVADLQALPALYRKLIERLLVG
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.