PharMolix/UniProtQA huggingface dataset:
Protein: LYSX_SULTO
Sequence: MILGVIYDLLRWEEKNLIQEARKLGHTVIPIYTKDFYYFYNNDSNETLGDLDVVIQRNTSHARAVITSTIFENLSYKTINDSSTLIKCENKLYTLSLLSKHGIRVPKTIVAFSKEKALELANKLSYPVVIKPVEGSWGRMVARAIDEDTLRNFLEYQEYTTLQFRYIYLIQEFVKKPDRDIRIFTIGDEAPVGIYRVNSRNWKTNTALGAKAEPLKIDEELQDLALKVKDIIGGFFLGIDVFEDPERGYIINEVNGVPEYKNTVRVNNFNVSEYLIRKIEEWIKK
What is the function of this protein?
Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.
What are the official names of this protein?
Alpha-aminoadipate--LysW ligase LysX, AAA--LysW ligase LysX.
What is the protein family that this protein belongs to?
Belongs to the RimK family. LysX subfamily.
Protein: ACHG_BOVIN
Sequence: MCGGQRPLFLLPLLAVCLGAKGRNQEERLLGDLMQGYNPHLRPAEHDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYGGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCVYWLPPAIFRSSCPVSVTFFPFDWQNCSLIFQSQTYSTNEINLQLSQEDGQTIEWIFIDPEAFTENGEWAIRHRPAKMLLDEAAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPVAVQDAHPRLQNGSSSGWPITAGEEVALCLPRSELLFRQRQRNGLVRAALEKLEKGPESGQSPEWCGSLKQAAPAIQACVEACNLIARARHQQTHFDSGNKEWFLVGRVLDRVCFLAMLSLFVCGTAGIFLMAHYNRVPALPFPGDPRSYLPSSD
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: HPCH_SALTI
Sequence: MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
What are the official names of this protein?
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: FABZ_ACET2
Sequence: MLTNVEIQNIIPHKYPFLLIDKILEVEPGKRAVGIKNVTINEPFFQGHFPGNPIMPGVLIVEALAQTACVAGLMLEENKGKLGVFTGIESMKFRRQVVPGDTLRLEAEFLAFKLGMGKAKVVATVDGEVAAEGQIKFAMIDTNKKA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_CHLT2
Sequence: MDYYTILGVAKTATPEEIKKAYRKLAVKYHPDKNPGDAEAERRFKEVSEAYEVLGDAQKRESYDRYGKDGPFAGAGGFGGAGMGNMEDALRTFMGAFGGDFGGNGGGFFEGLFGGLGEAFGMRGGSESSRQGASKKVHITLSFEEAAKGVEKELLVSGYKSCDACSGSGANTAKGVKVCDRCKGSGQVVQSRGFFSMASTCPDCSGEGRVITDPCSVCRGQGRIKDKRSVHVNIPAGVDSGMRLKMEGYGDAGQNGAPAGDLYVFIDVEPHPVFERHGDDLVLELPIGFVDAALGIKKEIPTLLKEGTCRLSIPEGIQSGTVLKVRGQGFPNVHGKSRGDLLVRVSVETPQHLSNEQKDLLRQFAATEKAENFPKKRSFLDKIKGFFSDFAV
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_BURTA
Sequence: MQDQYILALDQGTTSSRAMLFDRQGNIVSIAQKEFEQIYPRPGWVEHDPQEIWSTQAGVAAEAVTRVGLNGTSIAAIGITNQRETTIVWDRETGHPIYNAIVWQDRRTADFCDQLKAQGLSEKVRAKTGLPIDSYFSATKIRWILDNVEGAREKARQGKLAFGTVDSWLVWNFTKHELHVTDVTNASRTMLFNIHTLDWDDELLDALEIPRSMLPQVRASSEIYGPTKTTVFASKIPLAGIAGDQQAALFGQMCTSSGMVKNTYGTGCFLMMNTGETPIESQNNLVTTIAWQVDGKVNYALEGSIFIAGAVVQWLRDGLGIIKSASEIEALAAGVPHTDGVYLVPAFAGLGAPHWNARARGSLFGVTRGTTSAHLARAALDSIAYQSLDVLKAMEADSGIRIGELRVDGGASANNLLMQFQADLLGVDAVRPRVTETTALGAAYLAGLAIGYWKNVDELHSQWQLERRFAPSMQREQVSSCLCGWQRAVRAAKAWADDTQ
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: TOLB_BRUO2
Sequence: MKIGIINTKIRTVFSAFACMIAASLVCTMPARAVVEININKGVIEPLPIAITDFLSADQLGSNITSVIAADLERSGLFAPIDKGAFIEKISNPDAAPRFEDWKVINAQALVTGRITKQPDGRLKAEFRLWDTFGGQQMIGQQFFTTPDNWRRVAHIIADAIYERLTGDKGYFDTRVVFVDESGPAQKRVKRLAIMDQDGANVRFISDGRALSLTPRFSPNWQEVTYMSFEGGSPKVYLLQLETGQRELVGNFPGMTIAPRFSPDGQKVVMSLLQDDGSANIYTMDLRNRTTTRLTSSQAIDTGASYSPDGSQIVFTSDRGGRPQLYVMGADGSNPRRISMGDGSYSTPVWSPRGDLIAFTKQSQGQFSIGVMKTDGSGERLLTSGFHNEGPTWAPNGRVLMFFRKAAGAGGPKLFTIDLTGRNERQIQTPNFASDPAWSPLLE
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: IR221_CANTT
Sequence: MKFSTILTALTAVIATVAGYETSGKPHTVDILIDYSIKETPELSQNDVANWVNGDKYTLEYVVSNNEETEIAVVGVTGQFKNPVTNQIVTNLTTGQVGPITVAPGESIKFEQIVDVDLMANNYELFPYVFVAHDDLIKVIPCRGQLTSVVDATISFFDPRLILLELVLLVTFGAAAYFIYEIWGKQYLKGTAPVKVPARKSGSTVSKKGASATASGFDESWIPEAHLKKNKKKA
What is the function of this protein?
Is probably involved in a pathway contributing to genomic integrity.
What are the official names of this protein?
Increased recombination centers protein 22-1.
What is the protein family that this protein belongs to?
Belongs to the IRC22 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: A2MG_RALSO
Sequence: MICLAALAVAVPARADEAAAVRDKPNPTLAEVPASGYVPFTGQPFFLLSDASYGTDQEAMVRLEAPGREYKDELARYGGADILVYRVPQPLDFLKAQKNLHRIDVKANYTGEGLANTLAYLWDNWTRQARRAWQRVLSFATRSKAVEAAPQFSMGDQMAAPTRFSNPPQYAPLKGYELLGRFRYPIWEAKPIAPPKDVKLEGSSSEWMPQNVGNVMIPVGKLPAGLYIVEAVIGAYRAHTLLFVSDTVAVTKGTSQGMMVWTAERKSGKPVAGSAVSWTDGVGVLASGTTQADGTAELRHVAPERSYVLGVDRAGGVFISENFYYDSEIYNTKLYAFTDRPLYRPGDDVRVKFIGRNFRSATESTAPAAGDIKLDVIDPTGAPVATTTTRLSGETGADARFTLPSNAQAGGYTLRFDYGGSTYGGAFRVAEYIKPHFDVNLSLDKAGYGTGEAIKGKISLRYPDGKPVKDGKVSVSLRAQQVTMVEGELQYAGLFPVKLEQQELTTDGDGNAALTLPAAKEPSRYVVTVFANDGAAYRVKVTRELLVARGAAPYRLSTAANFTTPGQSVSFNLQPLPAVDGVRGASAPPAKWELVRLESRTRTEGALQPDAKGSATFPVKFEQPGSYTLSVRDAAGNLLAASSHWVAGDGVQTVPGNIEIVFDRDRYQIGDTAEALITFPQPVDDALLTLERDKVERHALLSGGGDWLALQRVTPSQYRARIKIGAEFSPNMTFSALTVRDGDMVFQNAGIVVTQPALDLTVRADKAVYAPGETVTLDLSSALAGKPVPANLTVSVVDEMVYVLQPEVAPSIVDFFYHPRRNSVRTTSSQSFISYDLALSSLPGKPGGTYGRHNERGVKVLERPRRDEQDTAAWVANLQTGADGRARMTFTMPDSLARWRVTVRAVSTTGAADGIVGQRTASIRSDKALYLKWTGPSRFRESDQPRLDMVAFNQTDKDITADWIVSGAGLNINQRVTLKRGANYLHAPLSGTPALQAGIVNAELKQDDRVSDRLQTTVKLDATGWLADRESIVPLTQLQGTRLPLGLPADARDVRLRVVGNTASQFARVADDLIEYPYGCAEQTASRLIPLALAQQSLAATGARLPDGNPAGTQGVDALLRTQRQRLALLAGTNGTFGWWGELTSSSALITSYAYYADWLASRAVGISLPADNWKQVLEAYKRTSQNEPLLHRALALWFANEMGLPVATPLSGVAAELARNAKAPADAEPAPGDSLIFVAPDSPRGRQVAAILTAQLMRQVGQPVPEALVSADIAARTALANDTSPLVQSLLLMGGGRSAADPAPLLARASAAMPTMDRAVALVWLQKGLGGLQGANVAAIQPVLSAGGWQAARSTVGVPTWRWAGAQPPAALDLASTPSDVTTQSAIVSYRSRAPEASRLPITVERKLYRLEPVDAAAPKDDAKAPKRAAADVTANAGITFKAKPVKPGDTLDSNALYVDEVVLTPRQGTYRYGLVEVPLPPGAEVEATTWGIQIDGLKGEPNEGNGPQPFERRAAYEMGQLSYNQPVPTLERPTALRQLVRFSLPGRFALPPARYFRMYQPEAKALQGDGKAASYPFKVE
What is the function of this protein?
Protects the bacterial cell from host peptidases.
What are the official names of this protein?
Alpha-2-macroglobulin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
Protein: GDF5_MOUSE
Sequence: MRLPKLLTLLLWHLAWLDLELICTVLGAPDLGQRTPGAKPGLTKAEAKERPPLARNVFRPGGHIYGVGATNARAKGSSGQTQAKKDEPRKMPPRSGGPETKPGPSSQTRQAAARTVTPKGQLPGGKASSKAGSAPSSFLLKKTREPGTPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPAVRKQRYVFDISALEKDGLLGAELRILRKKPLDVAKPAVPSSGRVAQLKLSSCPSGRQPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFERTARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
What is the function of this protein?
Growth factor involved in bone and cartilage formation.  During cartilage development regulates differentiation of chondrogenic tissue through two pathways.  Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity).  Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity).  Required to prevent excessive muscle loss upon denervation.  This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600).  Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).
What are the official names of this protein?
Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: TSACC_MACFA
Sequence: MEQHTSHPNRKVPAKEEANAVPLCRAKPSPSYINLQASSPPATFLNVQTTKLPSVDHKPKECLGLLECMYANLQLQTQLAQQQMAILEHLQASVTQLAPGRGSNNSSLPALSPNPLLNHLPQFSK
What is the function of this protein?
Co-chaperone that facilitates HSP-mediated activation of TSSK6.
What are the official names of this protein?
TSSK6-activating co-chaperone protein.
What is the protein family that this protein belongs to?
Belongs to the TSACC family.
Protein: RS10_NEIG2
Sequence: MANQKIRIRLKAYDYALIDRFAQEIVETAKRTGAVVKGPIPLPTKIERFNILRSPHMNKTSREQLEIRTHLRLMDIVDWTDKTTDALMKLDLPAGVDVEIKVQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DAPB_PENRW
Sequence: MGKFEDDGNSESVPLTRQRSESLASQTSTDSGLSIASESFMKNHKGGNTMPTDGGDGDRYLDVEDGGETGLDEPLISSGTKTGSSSRLRKIVWLLVLLCVGGWVLSFVLFLTQKRPDTAALSSASTVEIHEPGPATGGTSHGKPVTLEQVLSGTWSPKSHAISWIAGPDGEDGLLVEQGEKQDAFLRVKDIRSSEDGVDNLETRVLMKKGYIWFDGEAMLSAKTWPSPDMNRVLVMTDIQSNWRHSYFGKYWILDVATQKAEPLDPGNLSGRVQLAAWSPTSDAVVFVRENNLYLRKLTSLEVTPITKDGDENLFYGVPDWVYEEEVFSGNTGTWWSDDGKFVAFLRTNETAVPEYPIQYFRSRPSGKQPPPGLENYPEVRQIKYPKPGSPNPIVNLQFYDVEKNEVFSFEMPEDFVDDERIIIEVVWASEGKVLIRETNRESDVVKIFVMDTKARTGKLVRSDDIAALDGGWVEPTQSTRVIPADPKNGRPHDGYVDTVIYEGYDHLAYFTPFDNPEPVMLTKGNWEVVNAPSAVDLKKGLVYFVATKEAPTQRHVYSVKLDGSDLRPLTDTSAPGFFDVSFSHGAGYGLLSYKGPAVPWQAVINTQGDEIDFINLIEENVELAKMVEESAIPTEVYSNVTIDGYTLQVLERRPPNFNPEKKYPVLFFLYGGPGSQTVDRKFTIDFQTYVASNLGYIVVTVDGRGTGFIGREARCLVRGNIGHYEAIDQIETAKIWASKSYVDESRMAVWGWSYGGYMTLKVLEQDAGETFQYGMAVAPVTDWRFYDSIYTERYMHTPEHNPSGYANASIDDVMALGHSVRFLIMHGVADDNVHLQNTLVLIDKLDLKNIDNYDMQVFPDSDHSIQFHMAHALVYERLSSWLINAFNGEWHRTANPKPQEST
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: ACPS_BARQU
Sequence: MIVGLGNDLIDIRRIERMLVRYGDRFVQRIFTDIEQNKSESLQKKSSSYAKRFAAKEACAKALGTGIACGVNWKDMGVINLPSGKPIMKLTNRAQMQLQKLLPLHHDAIIHLSMTDDFPWAQAFIIIEALPRG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YN67_SCHPO
Sequence: MSITLSSRGRKIRKLPKSLEFPLDGSIDKLRDEVSSVTRLPVERLRFSTADGTTLLPNTTLRKYGVGPGATIWVKDLGPQIGWRTVFMIEYLGPLVIHLFFILNYKWIYRKDYNLCLNQKIAFVLVMLHFMKREYESIFVHRFSLATMPLRNIFKNCAHYHLLSGLFLAYFIYGPWHANDYIKPNHLLFLIVGWAFAVLSNFRTHIILRDLRPAGSKKRVIPTGYGFNLVSFPNYFFESLGWLFFALLTKSWASWIFLFVGSAQMFVWAKKKHARYLKEFPNYPRSRKIMIPFFL
What are the official names of this protein?
Putative enoyl reductase C646.07c.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HRCA_LEUCK
Sequence: MLTDRQKLILSAIIYEYTQTARAVGSKSLQEQLNIKVSSATIRNEMAALESASLIKKLHTSAGRVPSRAGYRYYLDHLMANHSVTEHDVNMVIQSFRGNFHEIDDLLDESARTLSEFTGATAIILKPQRHDIKVSGFRLVPLENQQLIAVLVTSDGKVTSQTFKLPRELAISSLDSMVKYINDQMTGRPVLEVLQMMQSDELPTQMSRVIKTPGAFLQLFGDVLSRSVGDQVHIGGRLNVLNFDESLNNKADLKRLLEFLESAKDIRNVAQTLGSHTVVKISQEIHEPLLKSFSLITRGFTIPNQGDGVIALLGPIRMPYARNILLIDAYGEALTQKMIEYT
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ADEC_BRUAB
Sequence: MRHCDSFCELIPMKGCEAMLEWMIDQGAGREPADIVLKGGRFLDLITGELVESDIAICEDRIVGTFGTYRGKHEIDVSGRIVVPGFIDTHLHIASSQVTPHEFDRCVLPQGVTTAICDPHEIANVLGAEGIRFFLDSALETVMDIRVQLSSCVPATHMETSGAELLIDDLLPFADHPKVIGLAEFMNFPGVLAKDPECMAKLRAFQGRHIDGHAPLLRGLDLNGYIAAGIRTEHEATNAEEALEKLRKGMYVLVREGSVSKDLKALMPIITERHAQFLALCTDDRNPLDIADQGHLDYLIRTAIAGGVEPLAIYRAASVSAARVFGLFDRGLVAPGQRADLVVVDSLEGCHAEIVLSAGRVVSEALFAARKPVAEVGRNSVKAPRVTASNFRSQSNSGKTRAIGIVPGKIITQNLEFDLKVGPNGVEPDLERDVVKVAVIERHGKNGNIATGFVHGFGLKAGAIASTVSHDSHNICVVGASDEDIATAANRLGEIEGGFVVVRDGKVLAEMPLPIAGLMSTEPYETVREALRKLRHAAEDLGSVLEEPFLQLAFIALPVIPHLKITDRGLVDVDKFEFVGN
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: LUZ_ARMME
Sequence: MSFFDSVKLDLVGRLFGIRNRGLAVTCCAVAVASIIAFPYIRRDYQTFLSGGPSYAPQNIRGYLIVCVLALFRQEQKGLAIYDRLPEKRRWLPDLPPRDGPRPITTSHIIQRQRNQAPDLKFALEELKATVIPRVQARHTDLTHLSLSKFEFHAEAIFLLPSVPIDDPKNVPSHDTVRRTKREIAHMHDYHDYTLHLALAAQDGKEVVSKGWGQRHPLAGPGVPGPPTEWTFIYAPRNEEELAVVEMIIEASIGYMTNDPAGKTIA
What is the function of this protein?
Luciferase; part of the gene cluster that mediates the fungal bioluminescence cycle (PubMed:30478037).  Uses the fungal luciferin 3-hydroxyhispidin as a substrate to produce an endoperoxide as a high-energy intermediate with decomposition that yields oxyluciferin (also known as caffeoylpyruvate) and light emission (By similarity).  The fungal bioluminescence cycle begins with the hispidin synthetase that catalyzes the formation of hispidin which is further hydroxylated by the hispidin-3-hydroxylase, yielding the fungal luciferin 3-hydroxyhispidin.  The luciferase then produces an endoperoxide as a high-energy intermediate with decomposition that yields oxyluciferin and light emission.  Oxyluciferin can be recycled to caffeic acid by caffeoylpyruvate hydrolase (PubMed:30478037) (Probable).
What are the official names of this protein?
Luciferase, Fungal bioluminescence cycle protein luz.
What is the protein family that this protein belongs to?
Belongs to the fungal luciferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HIS6_SHESR
Sequence: MLAKRIVPCLDVKDGCVVKGVQFRNHEIVGDIVPLAARYAAEGADELVFYDITASAHDRVVDKSWVSRVAEQIDIPFCVAGGIKTIGQARELLAFGADKISVNSPALSDPSLISRLQDEFGRQCIVIGIDSFYDAASDSYKVKQFTGDEAATKETAWYTQDWVEEVQKRGCGEIVLNVMNQDGVRGGYDIKQLSLVRQLCDVPLIASGGAGTMAHFRDVFIEAKVDAALAASVFHKAIINIGELKQYLAAEGIAIRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHF2_CULQU
Sequence: MASFCLSRCCALRGSTAVGWSLRTIGTSRVSLAGEGERPPPMIDLEDKSLPIPIYKEKHNEPLKLQKSRLLYQSRKRGMLENGLLLSTFAAKYLESLDARQTKLYDTLINMPTNDWDIFYWATGVKPTPQEYDNEIMNMLKEHVKNANKEKRLCQPALY
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2, mitochondrial, SDH assembly factor 2, SDHAF2.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ASTE1_DANRE
Sequence: MGVQGLKTYIESSSRNDLKTWAFRDKQLIIDGCNLFYSLCFDSNLDQIHGGDYDTFEKVVRQFFENLSACDVHPYVVIDGGDDHTDKKWDTLLTRKQKKIKDAYDLSVGKRRQVLPLLTEKVFKQVLKKLKVPVVQTLEEADWEIAALAEEWNCPVLSNDSDFYIFNLRAGLLPITHFHWRKVRVNRKTNQKFILSKHFIARKFCKSFKMNVSLLPVFASILGNDYVKLPNIKNRHWERYSNPGSENPQIEGLLNWLSQFSGPDEAISALLRPTSNKTKAQEELSHGIQDYKLVPGSLAQIFRSTKVPQKISKGPLHVLPRWTLRPILDGKMSSYIINVLLHNRASLNAQVEDFQLPSANETSLHIRQVFYGLLLLGEQQTAGKRESVKGTTKRYVVEYSRQQIKRSSENVEAIQTKAMEGLRLETLYQEPHAVRLQVILDTLGVSCEMLKGTPDALQLQMFVTRYWLVNAEPQPCRVHLWGLLLGMVYGKLSSSPNAQKDMLSRLRVKASRKGGSVDIDVAHAYSQWQSCLKYSLNLNYLLSFPLTEPDCASLYRGSLVHQAVGELRRGISLEALLVKGSSAERIFKQLKDIIVSLMGDDFIKKMKSGLEHRDAGKTQRASKGQKDELDIYFEQMMIESIDSEDEELLDVRKSKAKNHLMELPVCPIRARHKAKARNARHPCKKYERRCFE
What is the function of this protein?
Possible role in EGF receptor signaling.
What are the official names of this protein?
Protein asteroid homolog 1.
What is the protein family that this protein belongs to?
Belongs to the asteroid family.
Protein: TRI11_RAT
Sequence: MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECREVSAQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCAAHREPLTTFCGDDLSLLCPTCERSEHWAHRVRPLQEAADDLKGRLEKSLEHLRKQMEDAMLFQAQAEETCALWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQKLEEEELEVLPRLREGAARLGQQSTQLAALVSELESRCQLPALGLLQDIKDALCRVQDVKLQPPAVVPMELRTVCRVPGLVETLRRFRGDITLDPDTANPELVLSEDRRSVQRGEQRQALPDSPERFDPGPCVLGQERITSGRHYWEVEVGDQTSWALGVCKETVNRKEKGELSAGNGFWILVFLGSFYNSNERAFSPLRDPPKRVGIFLDYEAGHLSFYSATDGSLLFIFPETPFSGTLRPLFSPLSSSPTPMTICRLIGVSGDTLGPQ
What is the function of this protein?
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX.  Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis.  May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences.  May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity).  Mediates MED15 ubiquitination leading to proteasomal degradation.  May contribute to the innate restriction of retroviruses.  Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression.  Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain.  May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.  Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2.  Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM11, Tripartite motif-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the nucleus, colocalizes with PAX6.
Protein: ALLN_ALLCG
Sequence: QAKVTWSLKAAEEAEAVANINCSGHGRAFLDGILSDGSPKCECNTCYTGADCSQKITGCSADVASGDGLFLEEYWQQHKENSAVLVSGWHRTSYFFNPVSNFISFELEKTIKELHEIVGNAAAKDRYIVFGVGVTQLIHGLVISLSPNMTATPCAPQSKVVAHAPYYPVFREQTKYFDKKGYEWKGNAADYVNTSTPEQFIEMVTSPNNPEGLLRHEVIKGCKSIYDMVYYWPHYTPIKYKADEDIMLFTMSKYTGHSGSRFGWALIKDETVYNKLLNYMTKNTEGTSRETQLRSLKILKEVTAMIKTQKGTMRDLNTFGFQKLRERWVNITALLDKSDRFSYQKLPQSEYCNYFRRMRPPSPSYAWVKCEWEEDKDCYQTFQNGRINTQSGEGFEAGSRYVRLSLIKTKDDFDQLMYYLKIMVEAKRKTPLIKQLSNDQISRRPFI
What are the official names of this protein?
Alliin lyase, Alliinase, Cysteine sulphoxide lyase.
What is the protein family that this protein belongs to?
Belongs to the alliinase family.
What are the subcellular locations of this protein?
Vacuole.