PharMolix/UniProtQA huggingface dataset:
Protein: PNP_ERWT9
Sequence: MLNPIVQKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGQKKAKPGQGFFPLTVNYQERTYAAGRIPGSFFRREGRPSEGETLTSRLIDRPIRPLFPEGFVNEVQVIATVVSVNPQVNPDIVAMIGASAALALSGLPFNGPIGAARVGYLNDQYVLNPTSDELKESKLDLVVAGTKGAVLMVESEAELLSEDQMLGAVVFGHDQQQIVIDNINALVAEAGKPRWDWQPEAVNEALRSRITALAESRLSDAYRITEKQERYAQVDVIKSETSAALLAEDEALDAAEISDLLHALEKDVVRSRILRGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGETQALVTATLGTARDAQNLDELMGERTDNFLFHYNFPPYSVGETGMVGSPKRREIGHGRLAKRGVLAVMPKGDAFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKDENNFVVLSDILGDEDHLGDMDFKVAGSREGITALQMDIKIEGITREIMQVALNQAKGARLHILGVMEQAISGPRGDISQFAPRIHTIKISVDKIKDVIGKGGSVIRALTEETGTTIEIEDDGTVKIAATDGDKAKFAIRRIEEITAEIEVGRIYNGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVTDYLQMGQEVPVKVLEVDRQGRVRLSIKEAGEQAQPEAEAVPAAPEAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_RHOPT
Sequence: MSNLENLQSQILADIAAAADEAALEAVRVGALGKKGSISALLATLGKMDPEQRKTEGAAINRAKEAVTDALTARRDVLKAAALDAKLAAETIDVTLPMREPAAEQGRLHPLSQVWDELTAIFADMGFSIAEGPDIETDDYNFTKLNFPEGHPAREMHDTFYFNPKEDGSRLLLRTHTSPVQVRTMLSQRPPIRVICPGRTYRSDSDQTHTPMFHQVEGLVIDKGSHLGHLKWILHEFCKAFFEVDNVNMRFRPSFFPFTEPSLEVDIQCRRGKDEIRFGEGEDWLEILGCGMVHPNVLTACGLDPDEYQGFAWGMGIDRIAMLKYGMSDLRQLFEADVRWLNHYGFKPLDIPTLAGGLSS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H14_RABIT
Sequence: MSETAPAAPAAPAPAEKTPVKKKARKSAGAAKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAAAGEAKPKPKKAGAAKPKKPAGAAKKPKKATGAATPKKGAKKTPKKAKKPAAAAGAKKAKSPKKAKAAKPKKAPKSPAKAKAVKPKAAKPKAAKPKTAKPKKAPAKKK
What is the function of this protein?
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber.  Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers.  Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
What are the official names of this protein?
Histone H1.4.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Mainly localizes in heterochromatin.
Protein: Y2194_YERPS
Sequence: MMKINNLPRLIRTFLPATLLMLPLVWQTPALAQSASCTQGSTCVSVGGNNDPMSKEQARQSQQQWDETNRLRNKMNNRVEKDFDKNDRAVDAKDNCERSDNLNAYWEPNTQRCLDRLSGRKINP
What are the official names of this protein?
UPF0482 protein YPTB2194.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: PE23_MYCTU
Sequence: MQFLSVIPEQVESAAQDLAGIRSALSASYAAAAGPTTAVVSAAEDEVSTAIASIFGAYGRQCQVLSAQASAFHDEFVNLLKTGATAYRNTEFANAQSNVLNAVNAPARSLLGHPSAAESVQNSAPTLGGGHSTVTAGLAAQAGRAVATVEQQAAAAVAPLPSAGAGLAQVVNGVVTAGQGSAAKLATALQSAAPWLAKSGGEFIVAGQSALTGVALLQPAVVGVVQAGGTFLTAGTSAATGLGLLTLAGVEFSQGVGNLALASGTAATGLGLLGSAGVQLFSPAFLLAVPTALGGVGSLAIAVVQLVQGVQHLSLVVPNVVAGIAALQTAGAQFAQGVNHTMLAAQLGAPGIAVLQTAGGHFAQGIGHLTTAGNAAVTVLIS
What are the official names of this protein?
Uncharacterized PE family protein PE23.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PE family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YIDD_PARDP
Sequence: MSPFAHLLALPVRAYRLVASPWVGHGCRFQPTCSAYALEALERHGAAKGGWLAARRVCRCHPWGGHGFDPVPGSEAPRQD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL14_BRUME
Sequence: MIQMQTNLDVADNSGARRVMCIKVLGGSKRRYASVGDIIVVSIKEAIPRGRVKKGDVMKAVVVRTAKDIRRPDGSVIRFDNNAAVLIDNKKEPIGTRIFGPVPRELRAKNHMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: WECF_ECOL6
Sequence: MTVLIHVLGSDIPHHNRTVLRFFNDALAATSEHAREFMVAGKDDGLSDSCLALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPKLWLALLSGGIKPSQFFWHIWGADLYELSSGLRYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLYFPTRMDPSLNTMANDRQREGKMTILVGNSGDRSNEHIAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQVLSEKLEFDAYLTLLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDIVREAQRQLASVDKNTIAFFSPNYLQGWQRALAIAAGEVA
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS19_NITOC
Sequence: MPRSIKKGPFVDPHLQKKVLEASASQSRRPIKTWSRRSMVVPEMIGLTIAVHNGRQHVPILVTENMVGHKLGEFSPTRTFKGHVANKKSR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SUB2_PLAF7
Sequence: MLNIIYVVSLILIKFIFYKECNNNNNYYLSNIELYNYKLRKRNRILNNNINDRKSFLSDLEQNYKPLFDIYELSANFEKRRKELEKKTKGEENEIEKKKENDLEKKKENEIEKKKENDLEKEYNDVINLLELSLSSEYKELNADVSNNDNSGHEENNKHKLNKKNSSNYKNDKSLDELIKGAILKLKQNPNIKNKNMLDYDKIFKIIKEKLINKNLASNKIKGGDNEKLKEEKKQSDISTNVEVKKDIINDQLNKGIPTKKENKDDMINKESNKEDITNEGKSNSLNNLNTLNNDGNIITKVYDHYTIVTNSNDILNDISIDASDISKNSIGGINIPFNENDNSSFTHQRYIVLSNNGEKKYKIVLMTKNPKFMDMDGIYDEEEKKESLIELNQKVNKEENTNLYDGTGTLYYGKKSKKEKENTQQKGGNNPNVDINILNNNNNNNNNNNSNNNSNSMNDEEINYNNNNNNKESPSMFRRFINFLSFSGNENETEDTLIYHNKNDNSYKNKKEGTGKNNDNNDPNNNNNKKILLNVDKLVDQYLLNLKNNHTSKQELILVLKGELDLHSKNMKNVINNAKKNLEKYFKEHFKEFDKISYDISTPINFLCIFIPTLFDMNNMDLLKQALLILHNDLHEYVENWSFSSTYHTYEADYIKEQDSVYDRSPKKKYIKASKKLYNNKYSFLNKFLNIEPLILFAKKLNSKRSNIEKEILNFLPKELRDYSTWNLSIIRVFNAWFLAGYGNKNVKVCVVDSGADINHVDLNGNLYIPEYNEKYEMTQDFYNFMVKNPTDASGHGTHVTGIIGGVANDLGVVGVAPNITLISLRFIDGKKYGGSFHAIKALNVCILNKAPIINASWGSSHFDVNLHLAVERLKYTLNGKGSVLIAASGNKSNDNDISPLYPATFTFPHVYSVASISRNFEISPFSNYGHKSVHILAPGHHIYSTIPNNSYKIFTGTSMAAPHVCGVSALVYSVCYNQGFIPQAEEVLDILTRTSIKIISTKKRTINDSLVNAEGAVLTTLLGGLWMQMDCYFVKFNLEKGKKKHIPVVFSAYKKGVYETDIVIAIIPIDGKSKIYGEIHIPIKIVTDVNIPNFQESPRRGKNYTIDSNEAQHDEVLSYICENALYNLYEYDSHYLLASVILFFLALLSIFVGMIYMKSRKHSDKKCSKNLIKSNYIPEMDDGMEETQQLQQERRQYFRELFGENLEKNYDQHFVQDFGQDFRQDFKLGSTPDLKQYSDIDLQNKIQQPERKTVKIIINNFEDRKKETKRRLLKGLNYDGENAKKHDFTNESISNSRKNFKFSNNTEMKKNTIKSEDVKIASDDNVNKAMNQLDDMFMK
What is the function of this protein?
Serine protease which plays an essential role in the shedding of AMA1, MSP1 and MSP7 from the surface of the invading merozoite; this step is essential for productive invasion and the release of the adhesion between the erythrocyte and the merozoite (PubMed:16879884, PubMed:19214190).  May cleave TRAMP/PTTRAMP, thereby shedding TRAMP from the merozoite surface during erythrocyte invasion (PubMed:16879884).
What are the official names of this protein?
Subtilisin-like protease 2, Merozoite surface sheddase, MESH, PfSUB2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, microneme membrane; Single-pass type I membrane protein. Note=In mature schizonts, localizes to micronemes at the merozoite apical region (PubMed:23834729). Immediately after schizont rupture, secreted from the micronemes to the merozoite surface where it redistributes in an actin-dependent manner to accumulate at the posterior end of newly released merozoites (PubMed:23834729).
Protein: LCMT1_BOVIN
Sequence: MAASLRRPSFTTCSSPTDTDDEGVRGTCEDASICKRFAVSIGYWQDPYIQHLVRLSKERKAPEINRGYFARVHGVSQLTKAFLRKTECNCQILNLGAGMDTTFWMLKDEDLLPRKYFEIDFPMIVTRKLHSIKLKPLLSKPILDLHSEDTLQMDGHMLDSTRYAIIGADLRDIADLEEKLKKCNMSTQLPTLLIAECVLVYMTPEQSANLLKWAANSFEAAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQRERLLSSGWESASAIDMMEVYSRLPRAEVIRIEALEFLDEMELLEQLMQHYCLCWATKGGSELGLKEITY
What is the function of this protein?
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
What are the official names of this protein?
Leucine carboxyl methyltransferase 1, [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
Protein: MLTF_VIBPA
Sequence: MQIRHFNRLKRSVLLFASVLLLSACQIESQPKSEFEKIQERGVLRVGTLNNQLSYYIGPDGPAGLDYELARKFAEELGVKLEIKPAFRQADLFPALKKGDIDIIATGLNQTSQAVKRFRPGPAYYYVSQQVVYKKGQLRPRDIEQLIEYQASKDSQSEEDVNAGAQTLKIVEQSQYVPTLTALKKQYPELQFEIVGDADTRDLLKHVSTGELRFTVTDSVELSLAQRLYPDLALAFELTEDQPVSWFTRRSEDESLYAMLIEFFGNIKQSGELASLEEKYIGHIEAFDYVDTRAFIRALDDKLPRWAPLFQKYSEEFDWRLIAALAYQESHWKPKAKSPTGVRGMMMLTLPTAKSVGVTDRLNPEQSVRGGVEYLRRIVARVPDTINEHEKIWFALASYNIGYGHMMDARRLTKAQGGDPNAWADVKDRLPLLRQKRYYSQTRYGYARGDEARNYVENIRRYYQSIIGHVSQKPSIDEDTDDLQVIPPLNPELLISGAVETIAEEVSGASDITNEVDEDLDQEEE
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: PSA_ACIFD
Sequence: MSMPFYVAPEQLMKDRADYARKGIARGRALIGAVWEGGIIIVAENPSRSLHKLSEIYDRIAFGGVGKYNEFDQLRVAGIRHADLKGYAYAREDVDARSLANLYAQYLGTVFTHEMKPLEVEILVAELGNGHRESQLFQILYDGTVMDEREFAVLGGDADAIAERFRALYDASGPRERLLQSARDALSGQRPPIGADDLEVVVLEDRGERRCFRRLEVDEVREALGDQPEGSA
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_SALRD
Sequence: MDVHYDADPALIHDKQVAVIGYGSQGHAHALNLHDSGVDVAVGLRPGSSSRPKAEQQGLTVMDIGEAAAWGDVVMLLIPDQHQKDVYEAKIAEHMTPGTALGFGHGFNIHYDRIEPPEAVDVFMVAPKSPGHLVRRTYTDGSGVPCLAAVDQDPSGGAMALAISYADAIGGTHAGVIETTFKDETETDLFGEQAVLCGGSQALIQAGFETLVDAGYPEELAYFECLHELKLIVDLYYEGGLEYMNHSVSDTAEYGGYTRGPRVIDDAVREQMQEILEEVQSGEFADEWIEEYEQGAPQLQEERAALTEHPIEQVGQTLRGMMPWLNGDETSADEDAPDAADTAPASSS
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RTF_SCHPO
Sequence: MQGKNNLSCRPDTEDNEELFVDDQLLSPIGDSKNTSSFIYLGNPISFHEYNYDETMVSPENVKTAIAGSAKDHETCRGFKKTGTTSYKDFVFSRDYTNWTPTFWVLLSQLIDEFLKESELNFVAARDLLIKTKRLPKPFNNLLIQFQIQVPNVSRRTVYRHLKGYFNIPGYERFQYVKKASSGSWGANDIITLEKEIAMFKKKKNWSDEQFLQYVWSDNHRDEMKTLYNCLYELIDRDKKSIYNYLRRKYNPFKKKCKWTIEDEAELKKLVEKHGTSWSLIGKLSNRLPMHCRDHWRDYIQPGEINRSPWTIQEKEKLIKTVNQYLQSNPSSPIQWSLISKNMRNRHRHHCRWKYYTLISRDIHNSSPFKLGDSIWLIERMMDLNVAEERMIDWKCLSEYANHLWTADACKSHFERIKKTLFIDGLSTFSDTLIHLHKMLNSSPEETYISNLHDSYTAFSNADDLC
What is the function of this protein?
Mediates site-specific replication termination at the polar replication barrier RTS1, a barrier which ensures that replication of the mat1 locus in S. pombe occurs in the centromere-proximal direction.
What are the official names of this protein?
Replication termination factor 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIDC_PSEF5
Sequence: MDIKRTILIVALAIVSYVMVLKWNQDYGQAALPTQNVASSTTAPGLPDAPTGTSAANDDIPRAASDTTAPAEAPVAASKDLIQIKTDVLDLAVDPQGGDIAQLRLPLYPRRQDHPEIPFQLFDNGNERTYLAQSGLIGSNGPDASPAGRPIYSAEKKSYQLADGQDQLVVDLKFSKDGVNYIKRFTLKRGLYDITVSYLIDNESAQPWTGAMFAQLKRDASSDPSSSTATGTATYLGAALWTSSEPYKKVSMKDMDKVNEDKSKAPITENVQGGWVAWLQHYFVTAWIPPKGENNQVLARKDSKGNYIIGYTGPSMTVAPGAKAETSAILYAGPKSQAVLKELSPGLELTVDYGFLWFIAQPIFWLLQHIHSLVGNWGWSIIFLTMLIKGIFFPLSAASYKSMARMRAVAPKLAALKEKFGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQAPFMLWITDLSIKDPFFILPIIMGATMFIQQQLNPTPPDPMQAKVMKMMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQQWYITRKIEAATKKAAA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FTSY_MYCTU
Sequence: MWEGLWIATAVIAALVVIAALTLGLVLYRRRRISLSPRPERGVVDRSGGYTASSGITFSQTPTTQPAERIDTSGLPAVGDDATVPRDAPKRTIADVHLPEFEPEPQAPEVPEADAIAPPEGRLERLRGRLARSQNALGRGLLGLIGGGDLDEDSWQDVEDTLLVADLGPAATASVVSQLRSRLASGNVRTEADARAVLRDVLINELQPGMDRSIRALPHAGHPSVLLVVGVNGTGKTTTVGKLARVLVADGRRVVLGAADTFRAAAADQLQTWAARVGAAVVRGPEGADPASVAFDAVDKGIAAGADVVLIDTAGRLHTKVGLMDELDKVKRVVTRRASVDEVLLVLDATIGQNGLAQARVFAEVVDISGAVLTKLDGTAKGGIVFRVQQELGVPVKLVGLGEGPDDLAPFEPAAFVDALLG
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).  Most of the substrate proteins are involved in stress regulation, lipid metabolism, intermediary metabolism, and cell wall processes (PubMed:29361248).  Shows GTPase activity (PubMed:29361248, PubMed:33412199).  Can also hydrolyze ATP, UTP and CTP (PubMed:33412199).
What are the official names of this protein?
Signal recognition particle receptor FtsY, SRP receptor.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. FtsY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: AMPP1_NEUCR
Sequence: MRSFWSFPSSCLTAVASSVPRPASRSQAARVLHNLPRALTAFPQPSRTTRAFSLTSRLFQHLRAASDEETMTVNTTDRLAALRSLMKERNVDIYVVPSEDSHASEYIAECDARRAFISGFTGSAGTAVVTLDKAALATDGRYFNQASKQLDENWHLLKTGLQDVPTWQEWTADESAGGKSVGIDPTLISPAVADKLDGDIKKHGGAGLKAINENLVDLVWGDSRPPRPSEPVFLLGAKYSGKGTAEKLTNLRKELEKKKAAAFVVSMLDEVAWLFNLRGNDITYNPVFFSYAIVTKDSATLYVDESKLNDEVKQYLAENGTGIKPYNDLFKDTEILANAAKSTSESDKPTKYLVSNKASWALKLALGGEKHVDEVRSPIGDAKAIKNETELEGMRRCHIRDGAALIKYFAWLEDQLINKKAKLDEVEAADQLEQFRSEQADFVGLSFDTISSTGPNGAIIHYKPERGACSVIDPDAIYLCDSGAQFCDGTTDVTRTLHFGQPTDAERKSYTLVLKGNIALDTAVFPKGTSGFALDALARQFLWKYGLDYRHGTGHGVGSFLNVHEGPIGIGTRKAYIDVPLAPGNVLSIEPGYYEDGNYGIRIENLAIVREVKTEHQFGDKPYLGFEHVTMVPYCRKLIDESLLTQEEKDWLNKSNEEIRKNMAGYFDGDQLTTEWLLRETSPF
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase P, AMPP, Aminopeptidase P, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: KAD_POLAQ
Sequence: MRLILLGAPGAGKGTQAQFICEKFAIPQISTGDMLRAAVKAGTEFGVAAKKIMDAGGLVSDDIIIGLVKDRLTQPDCSKGYLFDGFPRTIPQAQAMKDAGVPIDYVLEIDVPFDAIIDRMGGRRVHPASGRTYHIKYNPPKVEGKDDVTGDALIQRDDDKEETVRKRLQVYDDQTRPLVEYYSSWAAQANAADKVKAPAYRKVSGTGSVEDITTSIFAQLK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_PAUTO
Sequence: MEEIQRYLQLERSQQHDFLYPLIFQEYIYAFAHDPGFSRSILSENPGYDNKSSLLIVKRLITRMYQQNHFIISPNDSNQNPFWARNKNLYSQIISEGFAFIVEIPFSLRLISCLEGKKKKIVKYQNLRSIHSIFPFLEDNLSHFNFVLDILIPHPVHVEILVQTLRYWVKDASSLHLLRFFLNEYYNWNSLITPKKASSSFSKRNQRLFLFLYNSHVCEYESIFVFLRNQSSHLRSTFSGILFERIYFYGKIERLVNVFVKVKDFQANLWLVKEPCMHYIRYQRKSILASKGTSFFMNKWKCYLVTFWQWHFSLWFHPRRIYINQLSNHSLEFLGYLSSVRMNPSVVRSQILENSFLINNAIKKVDTLVPIIPLIASLAKAKFCNVLGHPISKPVRADLSDSNIIDRFGRIYRNLSHYHSGSSKKKSLYRIKYILRLSCARTLARKHKSTVRTFLKRLGSELLEEFLMSEEDVLFLTFPKASSTLQGVYRSRIWYLDIISINDLANHKSKF
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NPL42_CAEEL
Sequence: MVIEVPQTERVNDVDVFLSTQDGQIQRPKGPNCRHPVRQKCTNCLPVDPFDEEYLKEKDIKHMSFHAHVRKLLGSQGKGTTLKKPLENFRCSLKPNCDAHKPFPKGICTKCKPQVVTLNRQKFRHVDNIQIENQELVNQFLDYWRLSGHQRVGFLIGQYQPHLEVPLGIKATVAAIYEPPQHCREDGIEFLEDKNQKTIDNLLEMLGLQRVGWIFTDCWTANSAEGTVHYTRHKDSFFLSAEECITAAMLQNQHPNITEYSMDRHYGSKFVTVVASGDESMHVNFHGYQVSNQCAAMVEADILCPTLYTPELAYVRETPLSEEHYITDVQFSMKNEYGAEVMKNGRPLPVEYLLVDVPAGMPKEPHYTFHVGTSNKSKSAKFNVENRQAIGQLQGGANLIQYSSEFSTNQFLEQATNFHFLLYLVTNDQVQISDEWMKRLCDAVKAQDRGTAMEWAQECEDWHQLMALAHANGGSGNDVSDIPVIPNGDPFSGSSSGGSRGAVWSCGHCTFQNEAGRQDCSMCGLPAAD
What is the function of this protein?
In association with ufd-1 and ATPase cdc-48. 1 and/or cdc-48. 2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:22768338).  This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:22768338).  During S phase and in association with ufd-1, cdc-48. 1 and/or cdc-48. 2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371).  Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564).
What are the official names of this protein?
Nuclear protein localization protein 4 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the NPL4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes to the cytoplasm during mitosis. Nuclear localization upon nuclear membrane re-assembly is cdc- 48-dependent.
Protein: MCR1_ECOLX
Sequence: MMQHTSVWYRRSVSPFVLVASVAVFLTATANLTFFDKISQTYPIADNLGFVLTIAVVLFGAMLLITTLLSSYRYVLKPVLILLLIMGAVTSYFTDTYGTVYDTTMLQNALQTDQAETKDLLNAAFIMRIIGLGVLPSLLVAFVKVDYPTWGKGLMRRLGLIVASLALILLPVVAFSSHYASFFRVHKPLRSYVNPIMPIYSVGKLASIEYKKASAPKDTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR
What is the function of this protein?
Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E. coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0. 5 mg/ml to 2. 0 mg/ml.  The pHNSHP45 plasmid can transfer efficiently (0. 1 to 0. 001) to other E. coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell.  When transformed into K. pneumoniae or P. aeruginosa it also increases polymxin MIC 8- to 16-fold.  In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).
What are the official names of this protein?
Probable phosphatidylethanolamine transferase Mcr-1, Polymyxin resistance protein MCR-1.
What is the protein family that this protein belongs to?
Belongs to the phosphoethanolamine transferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.