PharMolix/UniProtQA huggingface dataset:
Protein: NU4C_NEPOL
Sequence: MTHFPWLSTIVLFPLLASLAIPWLPDRKGTTVRWYALGVGLIDFSLIAYMFGRYYDFEQTSLQFVEDITWIDRLHLHWSLGVDGLSMPLVLLTGFITTLATLAAWPVTKNPRLFYFLMLAMYTGQLGVFVVQDLLLFFLMWELELIPVYLLVSCWGGKKRLYAATKFILYTALGSIFILLGALTMPFMGIQGVTFDMSTLAYREYSLPVEILLYTGFLIAYGVKLPAIPVHTWLPDTHGEAHYSTCMLLAGILLKMGGYALIRINMNMLPHAHALFSPWLIGVGVVNIIYAALTSFAQRNLKRKIAYSSVSHMGFVLIGIGSLSEAGLNGAMLQMISHGLIGASLFFLAGTTYDRTRTLVLEEMGGLATFMPKTFALFTACSLASLALPGMSGFFAELLVFLGLVTSEAYSPTFRAIMTVFEAIGILLTPIYLLSMLRQLFYGRSIGRPKALIDAGPREVFVVSCLLVPILGIGIYPKLATAIYVNTTDHVVQHVLSALR
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PCNA_METLZ
Sequence: MLKATIEADIFRETIDAVSALVNECRLHVDEKGIRTITVDTSNVAMVSLELSASAFLTFAAEPCEIGLDIEKIRSMMSMIGKTDIVSLELDESGKKLKISFGGYEYSITLLDTKTIRKDPNAPNLNLPATFEVPGVMFNDAIKASSMVSDKISLAVSAETCVFTMNADGDSDRIKRELTGDDVHYLTCADARSLFSLDYLKDMGKSIGRAEKVQIRLGTDHPVQFSFVYAGGKGSVGYLLAPRIEAD
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp, Proliferating cell nuclear antigen homolog, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: RXB_XENLA
Sequence: MHLHSPPLMADGSFSLSGHLLRSPGGNPSRLHSIEAILGFAKEDSVLGSFQSEVSPRNAKEVDKRSSRHCLHKMTEEIHPQQEHLEDGQTGGYGDPYSAKTSSECLSPGLSTSNSDNKLSDDEQQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKLEVTSMKLQDSPMLSFNRSPQPSAMSALSSSLPLDSWLTPPLSNSTALQSLPGFVTTPTSLPGSYTPPPFINPASMGHALQPLGAMGPPPPYQCGANFVDKYPLEEIDPRNNSIASLRMKAKEHIQSFGKPWQTI
What is the function of this protein?
Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.
What are the official names of this protein?
Retinal homeobox protein Rx-B, Retina and anterior neural fold homeobox protein B, Rx2A, Xrx2.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PANB_RHIME
Sequence: MSVQTTKRRLSPASIEALKGERPIVSLTAYTTPIARLLDPHVDFLLVGDSLGMVLYGLDTTVGVTLDMMIAHGQAVMRGSERCCVVVDLPFGAYQESKEQAFRSAARILKETGCSAVKLEGGAEMAETVEFLVSRGIPVLGHVGLMPQLVNTTGGYRSVGRNEKEVAKIRRDAKAIDDAGAFAIVVEGTVEPVAREITATLRAPTIGIGASPACDGQILVSDDMLGLFNDFKPRFVKHFAELAPTISKAAEAYANEVKARSFPGIEHTFQVKR
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_THESM
Sequence: MPKFDVAKHDLERLVGKEFTVDEWEDLFLYAKCELDDIWEHEGKIYFKADAKDTNRPDLWSAEGIARQVRWALGMLRGLPRYSIEESNVMVYVDENLKDIRPYGVYAIVEDLELDEEALKQIIQLQEKVALTLGRKRKEVAIGTFDFDKLSPPFYYKAVEPQKIKFIPLNCEREMSADEILEEHEKGKEYGHLIKGRPYYPLLVDSEGNVLSMPPVINSETHGKVTEETKSIFIDITGWNLETIMLALNVIVTALAERGGKIRTVRVIYKDFELKTPDLTPKEFEVDLNYIKRLAGVELTDKDIKDLLERMMYEVDFVDRRVKLRYPAFRNDIMHPRDVLEDVLIAYGYNNIEPEEPELAVQGKGDDFVDFENAIRDLMVGFGLQEVMTFNLTNREAQFDKMNIPEEDIVEIENPISQKWSALRRWLLPSLMEFLSQNTHEEYPQRIFEVGKATLIDESRETKTISESKLVVAIAHPKVTFTEAKEILDSVLRHLGAEYTIREIEYGSFIPGRAGEIIVEGKKVGIIGEIHPQVLENWGVEMPVAAFEIFLRPFYKGSFL
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOLG_LACPL
Sequence: MAEAHVTKVGIVGIGFIGSDHLHRLTKTVANVDVTAVCDIVPGKAQKALDQQGLTATTYEDYHDLVNDPNVEVVVCTANNEAHYEIVMAALKAGKFTFCEKPLALDAKQCMDIIDSEKKLGRRMLQVGFMRHYAPEYVQMKKMIDDGVIGKPLMMDQRHYNQTQPEEYDSSRSIIETAIHEIDIDHWLVNDDYANIRVFSPKQTRHVQNAKIQDPQIVMIETKSGINIINEVFVRCQYGYDIKCDVIGEEGVLELPTVPQVATRLNAQYSTAILTDWKARFESAYDIEFRDFINHVSQNESPVGPSAWDGYIAAVTADAALKSLAEDGAKQDLDFPSTPAFYTESEKVSE
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.
What are the official names of this protein?
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, MI 2-dehydrogenase/DCI 3-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: GLYA_PERMH
Sequence: MLKHLKQVDQEVFEAVSKEFKRQQEHLEMIASENYTSYAVMEAQGSVLTNKYAEGLPHKRYYGGCEYVDIVEDLAIERLKKIYGAEHANVQPHSGSQANQAVYFSQLQAGDTIMGMSLAHGGHLTHGAKVNLSGIVFNAVQYGVNPETELIDYDQVYKLAKEHKPKMIVAGASAYSRIIDWAKFREIADEVGALLMVDMAHYAGLIAGGAYPSPVPYADFVTSTTHKTLRGPRGGFILSKAQYGKDIDKWVFPRLQGGPLMHVIAAKAVAFKEAMTEEFREYAHQTVKNAKVLAEELKAEGLRIVSGGTDSHIVLVDLRPLNVKGNQAEEALGRANITVNKNAIPFDPEKPMVTSGIRLGTAALTTRGMKENDMRRIAKNIVKVLKNLDNEKIIQEVKDDVLSLCSSYPLYPEWTEYYLD
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_BORPE
Sequence: MSHPEAPITPEVEADLAIARRGCDELLVESEFARKLARSRATGVPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQDLGHNVIFLIGDFTSTIGDPSGRNSTRPPLTREQIETNAKTYYAQASLVLDPARTEIRYNSEWCDPLGARGMIQLASRYTVARMMEREDFTRRFKGGVPIAVHEFLYPLLQGYDSVALKADLELGGTDQKFNLLVGRELQKEYGQEQQCILTMPLLVGTDGVEKMSKSKGNYIGISEAPESMFGKLMSISDTLMWRYYELLSFRSLADIAALKAEIDGGRNPRDAKVALAQEIVARFHSPQAAEAALAAFEARFRDGAIPEDMPEVTVGGAPQGILRILREAGLVASGSEAQRNVEQGGVRVNGDRVEDKSLQLSAGTYVVQVGKRKFARVKLVG
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBL_BOWSE
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYSFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: YHPK_CAEEL
Sequence: MIRRENRLRREFIFRKSLEEKQKSLEEKREKIRNALENNTKIDYNLRKDAIELAKGSDWGGQQYETDSEYRWAGAQDPKIVITTSRDPSSRLKMFAKEMKLIFPNAQRINRGHYDVKQVVQASKAQDSTDLIIFTETRGNPDGMLVCHLPFGPTAFFSMANVVMRHDIPNCGTMSEQYPHLIFDNLNSKLGHRFTTILKHLFPVPKPDSKRIITFSNSEDYISFRHHVYKTENDGEVELTEAGPRFELKPYQIKLGTLETLAAAEDEWVLRSYTNTARKRTFLSISRADDDE
What are the official names of this protein?
Brix domain-containing protein ZK795.3.
Protein: CONB2_LUPAL
Sequence: MGKMRVRFPTLVLVLGIVFLMAVSIGIAYGEKDVLKSHERPEEREQEEWQPRRQRPQSRREEREQEQEQGSPSYPRRQSGYERRQYHERSEQREEREQEQQQGSPSYSRRQRNPYHFSSQRFQTLYKNRNGKIRVLERFDQRTNRLENLQNYRIVEFQSKPNTLILPKHSDADYVLVVLNGRATITIVNPDRRQAYNLEYGDALRIPAGSTSYILNPDDNQKLRVVKLAIPINNPGYFYDFYPSSTKDQQSYFSGFSRNTLEATFNTRYEEIQRIILGNEDEQEYEEQRRGQEQSDQDEGVIVIVSKKQIQKLTKHAQSSSGKDKPSDSGPFNLRSNEPIYSNKYGNFYEITPDRNPQVQDLNISLTYIKINEGALLLPHYNSKAIYVVVVDEGEGNYELVGIRDQQRQQDEQEEKEEEVIRYSARLSEGDIFVIPAGYPISINASSNLRLLGFGINADENQRNFLAGSKDNVIRQLDRAVNELTFPGSAEDIERLIKNQQQSYFANGQPQQQQQQQSEKEGRRGRRGSSLPF
What is the function of this protein?
Has a lectin-like activity.
What are the official names of this protein?
Conglutin beta 2.
What is the protein family that this protein belongs to?
Belongs to the 7S seed storage protein family.
Protein: KAD_YERPN
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGLKAKEIMDAGKLVTDELVIALVKERITQEDCRDGFLLDGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVERIVGRRVHAASGRVYHVKFNPPKVEDKDDVTGEELTIRKDDQEATVRKRLIEYHQQTAPLVSYYHKEADAGNTQYFKLDGTRNVAEVSAELATILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBL_CUSJA
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid membrane; Single-pass membrane protein.
Protein: GDF8_SHEEP
Sequence: MQKLQIFVYIYLFMLLVAGPVDLNENSEQKENVEKKGLCNACLWRQNNKSSRLEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHVTTETVITMPTESDLLAEVQEKPKCCFFKFSSKIQHNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPEPGEEGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFLFLQKYPHTHLVHQANPKGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPGMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: VP30_EBOZM
Sequence: MEASYERGRPRAARQHSRDGHDHHVRARSSSRENYRGEYRQSRSASQVRVPTVFHKKRVEPLTVPPAPKDICPTLKKGFLCDSSFCKKDHQLESLTDRELLLLIARKTCGSVEQQLNITAPKDSRLANPTADDFQQEEGPKITLLTLIKTAEHWARQDIRTIEDSKLRALLTLCAVMTRKFSKSQLSLLCETHLRREGLGQDQAEPVLEVYQRLHSDKGGSFEAALWQQWDRQSLIMFITAFLNIALQLPCESSAVVVSGLRTLVPQSDNEEASTNPGTCSWSDEGTP
What is the function of this protein?
Multifunctional protein that acts as a viral transcriptional activator (PubMed:12163572, PubMed:27279615).  Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription (PubMed:12163572).  Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA (PubMed:27315567).  Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures.  Assists also stop-start transcription at gene junctions to promote transcription of downstream genes (PubMed:18829754).  Interaction with NP plays a critical role in transcription initiation by recognizing the RNA stem loop (PubMed:28593988).  Interaction with host RBBP6 interferes with NP-VP30 interaction and inhibits viral RNA synthesis.  Also acts as a suppressor of RNA silencing by interacting with host DICER1 and TARBP2/TRBP (By similarity).
What are the official names of this protein?
Transcriptional activator VP30, Ebola VP30, eVP30, Minor nucleoprotein VP30.
What is the protein family that this protein belongs to?
Belongs to the filoviridae transcriptional activator VP30 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Present in viral inclusion bodies due to its interaction with NP.
Protein: FEN1_ANOFI
Sequence: MGIHGLTKLIADQAPGAIKEQDIKNYFGRKIAIDASMCLYQFLIAVRQDGNVLQNEDGETTSHLMGMFYRTIRMLEHGIKPVYVFDGKPPQLKSAELEKRGEKRAEAEKMLAQAQELGEQENIDKFSKRLVKVTKQHNDECKKLLTLMGVPYIEAPCEAEATCAALVKAGKVFATATEDMDGLTFGTNVLLRHLTASEAKKLPIQELHYSRILQDIGLTNEQFIDLCIPLGCDYCGTIKGIGPKRAIDLIKQHGSIEEILENIDSSKHPAPEDWLYKEARGLFLKAEVVDCSTVDLKWSEPDEEGLIQFMCNEKQFSEDRMRNGCKKILKSRQGSTQGRLDSFFSITGSLSSKRKEPELKGSAKKKQKTGATPGKFKKGK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: LEXA_GRABC
Sequence: MLTRKQYELLLLIDGHLRKTGFSPSFEEMKAALNLKSKSGIHRLISALEERGFLRRRHHRARALEVIRMPEAASMPVPKTAPSAPSFASPPAFTPNVIQGSFSSRIAGVRAAQDASAVQLPLYGRIAAGMPIEALRDTSAYLSVPIDMLGNGEHYALEVAGDSMIDAGIFDGDTVIIQQSDLAENGQIVVALIDDTEVTLKRLRRRGKSVALEPANERHETRIFPADRVRVQGRLIGLLRRY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: ARCL_MYCPN
Sequence: MQKIVIALGGNALGNNPTEQKDLVQLPARQAVALLKQGYQILLGHGNGPQVGMIYNAFSAAKQVNPNTPTVPFAESGAMSQGYIGLHLLTALYNELLHQKLPHQAVYFLTQTLVEASDPAFQNPNKPVGPFYNTEETARSANPNSTVVEDAGRGWRKVVASPKPVDVLGIDAIKSSFNQGNLVIVGGGGGVPTIKTKSGYATVDGVIDKDLALSEIAIKVEADLFVILTAVDFVYINYGQPNEQKLTCINTKEAKTLMAANQFAKGSMLPKVEACLNFVQSGTNKTAIIAQLDQLAAAIAGKIGTKIVK
What are the official names of this protein?
Carbamate kinase-like protein.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
Protein: UREE_ALIFM
Sequence: MIKFTHLVHHHHDEHHHGEEHTHNTAELTICLTMQERTKSRLKVMLSDGSEAGLFLPRGTVLKEHDIVESDDGVQAMITAAEETVSTVYSDDLLLLAKACYHLGNRHVPLQVEAGWCRYLHDHVLDDMVQRLGLNVKVEQAKYQPEPGAYGGSSAGSHDGHHH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI11_TRIAR
Sequence: MANAISVGVAVQLVLTVLLASIPLRVIWNLFFHPLSYIPGPRLWIAFPIFRQIASIRGVFDAQMCEYHRKYGNAVRFSPNEVSFITEQAWRDIYDHRPNQLERFILSTTRRPDIFDANEIDHARYRKAMLPAFSPKGLQEQEPIVRGYIDTFIERLREVSATGESTDMVKWYNFTTFDIIGDLAFGESFGGLRNREYHFTISFTFEAFKLLSYLEAGAAYPLLLKILMAFTPQSLIEARDKKEEHAETTVRKRLDNRALHGRGDFMDYLLRNRGEKQGLNDKELVANASTLITAGSETTATILSGITYWLLQTPNVLQKVTEEVRSAFQSEADITFTSATSQLPYMLACFQEAFRHYPPVPTGMPRVTPSHGITKISGYDISPNTKVSVHQLAAYSHPDNFHRPREFVPERWLPDAKTNPSSPWYNDRRETVQPFNVGPRNCVGRNLAEQEIRVMLARVLWNFDLELAPESKNWTDQKTHFLWEKGALMCKLHDRFASK
What is the function of this protein?
Trichothecene C-4 hydroxylase; part of the gene cluster that mediates the production of the antimicrobial trichothecene harzianum A (HA) that plays a role in Botrytis cinerea antagonistic activity and plant defense priming (PubMed:21642405).  The biosynthesis of harzianum A begins with the cyclization of farnesyl diphosphate to trichodiene and is catalyzed by the trichodiene synthase TRI5 (PubMed:21642405).  Trichodiene undergoes a series of oxygenations catalyzed by the cytochrome P450 monooxygenase TRI4.  TRI4 controls the addition of 3 oxygens at C-2, C-11, and the C-12, C-13-epoxide to form the intermediate isotrichodiol (PubMed:21642405).  Isotrichodiol then undergoes a non-enzymatic isomerization and cyclization to form 12,13-epoxytrichothec-9-ene (EPT) which is further converted to trichodermol by the cytochrome P450 monooxygenase TRI11 via C-4 hydroxylation (PubMed:21642405).  The last step of HA synthesis is esterification of an octatriendioyl moiety to the C-4 oxygen of trichodermol.  The octatriendioyl moiety is probably produced by the polyketide synthase TRI17 and the esterification performed by the trichothecene O-acetyltransferase TRI3 (Probable).
What are the official names of this protein?
Trichothecene C-4 hydroxylase, Cytochrome P450 monooxygenase TRI11, Trichothecene biosynthesis protein 11.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: P23_THEBU
Sequence: MHKFTKVFFVAILVHTLKSGLVFTPVSGTAIDIDKDGKFADRITINHFQSDMEGYKAYTYQKEGDKYVNISKVFYGERLLKVGGYNMKCDYVFYIKVFWKGELAPFLIKLKYYSWSWAPYKKHFKLNPQLEWEEVFIPTIDETSETGYRRLFKQRMDNPFSLIGDDLLASYKPFKATKAEQVIAGTTEEEKSDKKKYVLMVVVVVVFVVVASLVVFLVKFCLK
What are the official names of this protein?
23 kDa piroplasm membrane protein, p23.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TLDD_ECOLI
Sequence: MSLNLVSEQLLAANGLKHQDLFAILGQLAERRLDYGDLYFQSSYHESWVLEDRIIKDGSYNIDQGVGVRAISGEKTGFAYADQISLLALEQSAQAARTIVRDSGDGKVQTLGAVEHSPLYTSVDPLQSMSREEKLDILRRVDKVAREADKRVQEVTASLSGVYELILVAATDGTLAADVRPLVRLSVSVLVEEDGKRERGASGGGGRFGYEFFLADLDGEVRADAWAKEAVRMALVNLSAVAAPAGTMPVVLGAGWPGVLLHEAVGHGLEGDFNRRGTSVFSGQVGELVASELCTVVDDGTMVDRRGSVAIDDEGTPGQYNVLIENGILKGYMQDKLNARLMGMTPTGNGRRESYAHLPMPRMTNTYMLPGKSTPQEIIESVEYGIYAPNFGGGQVDITSGKFVFSTSEAYLIENGKVTKPVKGATLIGSGIETMQQISMVGNDLKLDNGVGVCGKEGQSLPVGVGQPTLKVDNLTVGGTA
What is the function of this protein?
Metalloprotease involved in CcdA degradation.  Suppresses the inhibitory activity of the carbon storage regulator (CsrA).
What are the official names of this protein?
Metalloprotease TldD.
What is the protein family that this protein belongs to?
Belongs to the peptidase U62 family.
Protein: RS9_BRASB
Sequence: MAESIQSLDQLSQLKGAVTAPDAPKYEKKVDKFGRAYATGKRKDAVARVWIKPGSGKVTVNTRDIEVYFARPVLRMMIQQPLVAAARNGQYDVICTVAGGGLSGQAGAVRHGLSKALTNFEPELRGVLKKGGFLTRDSRVVERKKYGKAKARRSFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: KLP6_SCHPO
Sequence: MKEGSSISVAVRVRPFTEREKGLLAETPKSKEFLGDGSLAVSNTSSNTFCTNGIRKIVRVLDDNVLIFDPPEENPLAKVQKSLLPAGKRFRDVRYAFDRLFGEEASQEDVYKGTTEPLLDSVLQGYNATVFAYGATGCGKTHTISGRPDDPGIIFLTMRALLDRVEGLKRTMNVDISVSYLEIYNEKIRDLLVQDPLSMEKPKSLNICEDAEQNVSVPGLSYFTPTNLEEVMEIIIRGNSNRTMSPTEANAVSSRSHAVLQIYITQTPKSGEKQEESESQNSHKVRSVFSFIDLAGSERASATKNRGKRLVEGANINRSLLALGNCINSLCEPRRRQHVPYRDSKLTRLLKFSLGGNCRTCMIVCISPSSEHYDETHNTLKYGNRAKNIKTKVSRNVVSVDRHVSEYVRTIYELRQKVSILQKRIAEESKQLALNKEVRKISSREIKMLDARSMLKNSFDGSRDLQKSLIEHVRTLRRIEDEITLTKMWISIAKESDAMSGHNIKSVETRLAKLYDQRSLITAKVNPEEICKTFQNSISHIVSSFKGEGADMYADMLQDDVDLLKSIIENQILDAKHESETFSSTSRKLIQNLFLLFPLLPGNAIDVNESLARAFDQLVGIVPSEPTIQVPNLIEKGKAPLLSMFEIPRSPSRFKARSPSKAARVLKKPLKKRVRFSEVPTTSSVPPVEIKNKDSKPKVEKSLDKHNMNNDRSFLVPSRDARNSLTSLSLHSNVAKNKSSHSSKWPTHTLSPIITTALKQPVRRISLVSQPLQKTGGTENTPNA
What is the function of this protein?
Has a role in establishing metaphase during mitosis.  Required for chromosome segregation where it generates tension during kinetochore capturing.
What are the official names of this protein?
Kinesin-like protein 6.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic microtubules in interphase, mitotic kinetochores in metaphase and spindle midzone in anaphase and telophase.
Protein: Y2003_CHLSY
Sequence: MPAENSFDIVSDFDQQELVNAVDQTLREVQTRYDLKDAGVTITLTKTELIIEADSEMSLRSVRDVLETKALRRKLSLKIFDYGKPTDASGGRVRQVVTLRRGIDSELAKKLSKMIRDRFPKVQPRIQGDSLRVAGKSRDELQAVIAFLREREGEIPVPLQMTNYR
What are the official names of this protein?
UPF0234 protein Chy400_2003.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: CEF1_MAGO7
Sequence: MPVVKGGVWTNIEDEILKASVSKYGLNQWARVSSLLARKTPKQCKARWNEWLDPSIRKIEWSKDEDEKLLHLAKLMPTQWRTIAPIVGRTANQCLERYQKLLDEAEQKEAAAALGLTGTGEASAPTADSVRRLRPGEIDPDPETKPAKADTVDLDEDEKEMLSEARARLANTQGKKAKRKARERQQEESRRLAALQKRRELKTAGINVKVTTRKPGQMDYNADIPFEQKPAPGFYDTSEELARNERERAAFDPKKVQLATKRKGDQDEDADRKRRKNDKEGSQSASLQEALKAGRMQKMREAEQSSKRRALVLPEPQVGEGELEDIVKMGMIGERAGQMARESENDATRGLVGSYSSLNTGAPIRTPRAPEQEDHIANEIRNIRALQETQSSLLGGENTPLHEGVASTGFDGVAPRKQVMSTPNPLATPMRSGANGMGMTPGGPGATPRAPGQTPLRTPRDGFSLNSVGDEVASRQQLLKGLAALPKPKETEWDLELPEDQMEVDAAEALEEDASERDRREREIREAQEALERRRRTQVMQRDLPRPAVVDIDLFLKHADSIPDPSQSMVAREAAMLMANDAIKFPAAGVKPARSSKVQVEQVDDAALAEARLQVLVEAGSAPKPEDVQKAWDREKSNSLLLGLACYDDDEEEEQVAIMRAALEEVQQSIVSSAEKGNKLEKKLNLHHGGYKQRAEMLRKKIGEASEALSKANDALSAFKTLAVSEEITITRRLEALREEVAYVSRREREAQELYRRIREESDHMPVVTNGYH
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle control.
What are the official names of this protein?
Pre-mRNA-splicing factor CEF1.
What is the protein family that this protein belongs to?
Belongs to the CEF1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.