PharMolix/UniProtQA huggingface dataset:
Protein: RPOC_PECAS
Sequence: MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVVEGGMTNLERRQILTEEQYLDALEEFGDEFDAKMGAEAIQALLKNMDLEQECEQLREELTETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERVYRAGLASLHARVKVRITEEIKSIEGDVTHQTSIIDTTIGRAILWMIVPKGLPFSIVNQPLGKKAISKMLNTCYRILGLKPTVIFADQTMYTGFAYAARSGASVGIDDMVIPAKKAEIIEEAETEVAEIQEQFQSGLVTAGERYNKVIDIWAAANERVAKAMMENLSVEDVVNRDGVVEQQVSFNSIFMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGDVKEPLRERVLGRVTAEDVIKPGTADILVPRNTLLNEQWCDMLEENSVDVVKVRSVVSCQTDFGVCANCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSLKLNNVKFVMNGNGKLVITSRNTELKLIDEFGRTKESYKVPYGAVMAKGDGSDVSGGETVANWDPHTMPVVTEVSGFIRFADMIDGQTITRQTDDLTGLSSIVVLDSAERTGSGKDLRPALKIVDAKGQDVLIPGTDMPAQYFLPGKTIVQLEDGVQIGAGDTLARLPQESSGTKDITGGLPRVADLFEARRPKEPAILAEISGIISFGKETKGKRRLVISPLDGSDAYEEMIPKWRQLNVFEGEVVERGDVVSDGPESPHDILRLRGVHAVTRYITNEVQEVYRLQGVKINDKHIEVIVRQMLRKGTIVSAGSTEFLEGEQAEMSRIKIANRKLEADGKITATFSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRQASEAPVVPQVSADEASANMAELLNAGFGKRDDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: MLES_OENOE
Sequence: MTDPVSILNDPFINKGTAFTEAEREELGLNGLLPAKVQALQEQVDQTYAQFQSKVSNLEKRLFLMEIFNTNHVLFYKLFSQHVVEFMPIVYDPTIADTIENYSELFVEPQGAAFLDINHPENIQSTLKNAANGRDIKLLVVSDAEGILGIGDWGVQGVDIAVGKLMVYTVAAGIDPSTVLAVVIDAGTNNEKLLKDPMYLGNKFNRVRGDKYYDFIDKFVNHAESLFPNLYLHWEDFGRSNASNILNSYKDKIATFNDDIQGTGIVVLAGVLGALKISGQKLTDQTYMSFGAGTAGMGIVKQLHEEMVEQGLSDEEAKKHFFLVDKQGLLFDDDPDLTPEQKPFAAKRSDFKNANQLTNLQAAVEAVHPTILVGTSTHPNSFTEEIVKDMSGYTERPIIFPISNPTKLAEAKAEDVLKWSNGKALIGTGVPVDDIEYEGNAYQIGQANNALIYPGLGFGAIAAQSKLLTPEMISAAAHSLGGIVDTTKVGAAVLPPVSKLADFSRTVAVAVAKKAVEQGLNRQPIDDVEKAVDDLKWDPKY
What is the function of this protein?
Involved in the malolactic fermentation (MLF) of wine, which results in a natural decrease in acidity and favorable changes in wine flavors.  Catalyzes the decarboxylation of L-malate to L-lactate.  It can also use pyruvate as substrate.
What are the official names of this protein?
Malolactic enzyme, MLE.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: SMAD9_RAT
Sequence: MHPSTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQSLGPAPPSSPGHVFPQSPCPTSYPQSPGSPSESDSPYQHSDFRPVCYEEPLHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
What is the function of this protein?
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase.  SMAD9 is a receptor-regulated SMAD (R-SMAD) (By similarity).  Has been shown to be activated by activin type I receptor-like kinase-2 (ALK-2) which stimulates heteromerization between SMAD9 and SMAD4.  ALK-2 binds TGF-beta, activin and BMP.
What are the official names of this protein?
Mothers against decapentaplegic homolog 9, MAD homolog 9, Mothers against DPP homolog 9, SMAD family member 9, SMAD 9, Smad9, Smad8.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
Protein: RL17_NITSB
Sequence: MRHRHGYRKLSRTSSHRKALLKNLAIALIMNERIETTVAKAKTLRSYIEKLITKAKKGDFNAHREVFAYLQDKEATKKLMNEIAPKYNERNGGYTRIIRTRTRRGDAAPMAFIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: GYRA_MYCGO
Sequence: FRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCLTGDALVRLPFGQSMRIGDVAPGARTNSDNAGELKVLDRHGDPVFADRLFHSGDHQTFRVQTAEGYEVTGTSNHPVLCLVNLAGVPTLLWMLIEEIRPDDYVVLQRAPPVESGPANWRDAMEALLLGAFISEGFMSESRAGFNNVDRDYFNAVVAAYDAVVGGKRYVAQRTIASGSVLNELDIHDVSALKGTRLGVLCGQRSADKSVPEWLWQSPAAVKRVFLQALFEGDGSCSALPRNTIQVSYSTRSRQLAIDVQQMLLEFGVISRRYRHAVGEYKVVITNRAQAELFATQIGFGGAKQSKLTRILGSLPPCAGMDTNHVPGLAAFIRSHCDSEWVDKEWLRKHNIDRLSRWRRDGAEILSRIANPDVRAIATDLTDGRFYYAQVTSVTEAGVQPVYSLRVDSEDHAFLTNGFVSHNTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHN
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_USTMA
Sequence: MRLLKTHPILGLANSYLIDSPQPSNISYMWNFGSLLGVCLIIQILTGVFLAMHYTPSVDLAFISVEHIMRDVNYGWLIRYLHANTASFFFIFVYLHIGRGLYYGSYKSPRTLLWSIGVIILVLMMAIAFLGYVLPYGQMSLWGATVITNLLSAIPWIGQDFVEFVWGGFSVNNATLNRFFSLHYLLPFVLAALAAMHLLALHEHGSSNPLGVSGNTDRLPFHPYFTFKDLVTIFVFLLALSLFVFYMPNAMGHSDNYIPANPMQTPASIVPEWYLLPFYAILRSIPSKLIGVLAMFMSLLILLGMPILDTSRIRGSQFRPLMRFSFWTFVACFFILMFIGSQHVESPYVEIGAAATAYYFAWFLVVVPAIGIIENTLMDIALTEETSSFHRVV
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PNO1_COCIM
Sequence: MPAPTSRLRAPEELGKNAAASAPQINQNEDDVLIDSSAPLPEITTTSQDADTDMHVDEEGRPLFTPITATDGAYRIENRKVPVPPHRMSPLKAAWPKIYPPLVEHLKLQVRMNIKSKAVELRTSKNTTDTGALQKGEDFIKAFTLGFDVDDAIALLRLDDLYIETFEIKDVKPLNGEHLGRAIGRIAGKDGKTKFAIENASRTRVVLADQKIHILGGFRNIRIAREAIVSLILGSPPGKVYGNLRTVASRMKERF
What is the function of this protein?
Required for small ribosomal subunit (SSU) synthesis.  Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein PNO1.
What is the protein family that this protein belongs to?
Belongs to the PNO1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: RNC_CUPNH
Sequence: MNLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLYGMFGKLDEGDLSRVRANLVKQQALYEIAQMLQLSDTLRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFDAARALIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYNVIATHGAAHSQQFEVECTVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTRKQPVPQDPQLSLRLKE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2475_METMA
Sequence: MPTRTISISEEAYERLKSLKTSEKDSFSDVILKYYPRKRKLSEVLAEIGSNPELADAIEKASRDMRKAKMRNVDLDAGA
What is the function of this protein?
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Putative antitoxin MM_2475.
What is the protein family that this protein belongs to?
Belongs to the UPF0330 family.
Protein: METE_ECOLI
Sequence: MTILNHTLGFPRVGLRRELKKAQESYWAGNSTREELLAVGRELRARHWDQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVPARHQNKDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYMVPEFVKGQQFKLTWTQLLDEVDEALALGHKVKPVLLGPVTWLWLGKVKGEQFDRLSLLNDILPVYQQVLAELAKRGIEWVQIDEPALVLELPQAWLDAYKPAYDALQGQVKLLLTTYFEGVTPNLDTITALPVQGLHVDLVHGKDDVAELHKRLPSDWLLSAGLINGRNVWRADLTEKYAQIKDIVGKRDLWVASSCSLLHSPIDLSVETRLDAEVKSWFAFALQKCHELALLRDALNSGDTAALAEWSAPIQARRHSTRVHNPAVEKRLAAITAQDSQRANVYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRTLRLDFKKGNLDANNYRTGIAEHIKQAIVEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPIVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLQWGVEAFRINAAVAKDDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEEFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAKRIPAERLWVNPDCGLKTRGWPETRAALANMVQAAQNLRRG
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: LEU3_AROAE
Sequence: MKICILPGDGIGPEITAEAVRVIEALDLKFEMEEALLGGAAVDATGDPYPEATRKLAREADAVLLGAVGGPKWDTLPREQRPERGLLGIRKDLGLFANLRPAILYPELANASSLKPEVVAGLDILIVRELTGDIYFGQPRGLEVRDGERFGFNTMHYSESEIRRIGRVAFEAARKRNRRLCSVDKMNVLETTQLWRDVMIELAAEYPDVELSHMLVDNAAMQLVRAPKQFDVMVTGNMFGDILSDEASMLTGSIGMLPSASLDANNKGLYEPSHGSAPDIAGQGIANPLATILSVAMMLRYTFNQENGALRIENAVKKVLAQGLRTGDIFEPGTTKVGTKQMGDAVLAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBP4_YEAS1
Sequence: MEQNIISTIRDECIRHRSKYLTIAQLTAIAEAKINEFIITGKAKDQDLSSLLDKCIDILSIYKKNSKDIKNIISCKNKGAMISSNSVMIIQLNYVYYKVIHIIVTTNIPHLSEFAKIKLHKSTSDEGNGNNNNNEFQLMNIYNTLLETLLKDENIAKIKSFIKSSIKQTKLNHEQEECNLMRTGSYITSNQLNSLISSSANSASSQMEILLIDIRSRLEFNKSHIDTKNIICLEPISFKMSYSDHDLEKKSLITSPNSEIKMFQSRNLFKFIILYTDANEYNVKQQSVLLDILVNHSFEKPISDDFTKIFILESGFPGWLKSNYGRQVSSSFPSNNNIKDDSVYINGNTSGLSLQHLPKMSPSIRHSMDDSMKEMLVAPTPLNHLQQQQQQQSDNDHVLKRSSSFKKLFSNYTSPNPKNSNSNLYSISSLSISSSPSPLPLHSPDPVKGNSLPINYPETPHLWKNSETDFMTNQREQLNHNSFAHVAPINTKAITSPSRTATPKLQRFPQTISMNLNMNSNGHSSATSTIQPSCLSLSNNDSLDHTDVTPTSSHNYDLDFAVGLENLGNSCYMNCIIQCILGTHELTQIFLDDSYAKHININSKLGSKGILAKYFARLVHMMYKEQVDGSKKIPISPIKFKLACGSVNSLFKTASQQDCQEFCQFLLDGLHEDLNQCGSNPPLKELSQEAEARREKLSLRIASSIEWERFLTTDFSVIVDLFQGQYASRLKCKVCSHTSTTYQPFTVLSIPIPKKNSRNNITIEDCFREFTKCENLEVDEQWLCPHCEKRQPSTKQLTITRLPRNLIVHLKRFDNLLNKNNDFVIYPFLLDLTPFWANDFDGVFPPGVNDDELPIRGQIPPFKYELYGVACHFGTLYGGHYTAYVKKGLKKGWLYFDDTKYKPVKNKADAINSNAYVLFYHRVYGV
What is the function of this protein?
Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole.  Removes also ubiquitin from soluble proteins targeted to proteasomes.  Is essential to maintain a normal level of free ubiquitin.  Involved in the ammonium-induced down-regulation of the GAP1 permease and the UME3 destruction in response to oxidative stress.  Has a role in the RAD9 checkpoint response to TOP1 poisons.  Required for promoting coordination of DNA replication and avoids DNA overreplication (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 4, Deubiquitinating enzyme 4, Ubiquitin thioesterase 4, Ubiquitin-specific-processing protease 4, Vacuole biogenesis protein SSV7.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Cytoplasm. Late endosome membrane; Peripheral membrane protein. Note=Recruited to the late endosome by BRO1.
Protein: ATPG_RUTMC
Sequence: MAAGKEIRTQISSIKNTQKITSAMEMVAASKMKKAQDRMLASRPYCEKISNVIGHLAYAHSEFEYSYMNSSEKLQRIGVIIISSDRGLCGGLNTNLFRHILKQVVEYQAKSIEVDICTIGKKATSFFKNLGLNVKSVLTDLGDTPHFDDLLGTIKVMLDEFDADEIQQLSVAYNKFENIITQTPTIMQLVPMVAGESNNINHYWDYIYEPDAQEVLSALLVRYIEALVYQGLIENIACEQSSRMIAMKSATDNASDMVKELKLIYNKARQAAITQEISEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TIM9_DEBHA
Sequence: MDQLNVKEQQDFQQIVEQKQMKDFMRLYSNLVSKCFDDCVNDFTSNNLTTKETGCITKCSEKFLKHSERVGQRFQEQNALLMQNMQKR
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM9.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: COAD_AGRRK
Sequence: MTTAFYPGSFDPMTNGHLDVLVQALNVASKVIVAIGIHPGKKPLFSFEERAELINRSLADALPKKAADISVVSFDNLVVDAARKHGASLLVRGLRDGTDLDYEMQMAGMNRQMAPDIQTLFLPAGTASRPITATLVRQIASMGGNVSAFVPPAVLEALTGKLKDPAK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGLA_CAMJE
Sequence: MRIGFLSHAGASIYHFRMPIIKALKDRKDEVFVIVPQDEYTQKLRDLGLKVIVYEFSRASLNPFVVLKNFFYLAKVLKNLNLDFIQSAAHKSNTFGILAAKWAKIPYRFALVEGLGSFYIDQGFKANLVRFVINSLYKLSFKFAHQFIFVNESNAEFMRNLGLKENKICVIKSVGINLKKFFPIYVESEKKELFWKNLNIDKKPIVLMIARALWHKGVKEFYESATMLKDKANFVLVGGRDENPSCASLEFLNSGAVHYLGARSDIVELLQNCDIFVLPSYKEGFPVSVLEAKACGKAIVVSDCEGCVEAISNAYDGLWAKTKNAKDLSEKISLLLEDEKLRLNLAKNAAQDALQYDENIIAQRYLKLYDRVIKNV
What is the function of this protein?
Adds the first GalNAc residue on to the isoprenoid-linked bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose) carrier in the N-linked protein glycosylation pathway.  Acts first on the undecaprenylpyrophosphate-linked bacillosamine (Und-PP-Bac) substrate to yield the disaccharide.
What are the official names of this protein?
N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase, Protein glycosylation A.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family.
Protein: TX2B_MYRPI
Sequence: LIGLVSKGTCVLVKTVCKKVLKQ
What is the function of this protein?
Heterodimer protein that may serve both defensive (pain-inducing) and predatory (insecticidal) roles (PubMed:28513074).  Has membrane-disrupting activity and shows induction of non-specific calcium influx into cells, (PubMed:28513074).  Shows broad-spectrum activity against a diverse range of bacteria, and cell lines, as well as hemolytic activity (EC(50)=2. 18 uM) (PubMed:28513074).  In vivo, shows moderate insecticidal activity against D. melanogaster and potent anthelmintic activity against the veterinary nematode H. contortus (PubMed:32629771).  In addition, intraplantar injection into mice induces nocifensive behavior and mechanical allodynia (PubMed:28513074).
What are the official names of this protein?
M-myrmeciitoxin-Mp2b, M-MIITX-Mp2b, DELTA-myrtoxin-Mp1a B chain, Mp1a B chain, Pilosin-3 subunit b, Pilosulin-3b.
What is the protein family that this protein belongs to?
Belongs to the formicidae venom precursor-01 superfamily. Ant pilosulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNLJ_BORGP
Sequence: MSIKIQQEIEDLKKLIRKWDKEYYVDSLPSVEDFVYDNHILRLKELESRHPEYKTLDSPTLKFGSDLLNNFEEVEHSVPILSLDKVYDLDLLKSWIDKIDFNNSFNISVEPKIDGCSIVLYYKDGILEKALTRGNGKFGNDVTKNIRTIRHIPLFLDEKVDLVLRGEVYITKENFFKINKFLEKPYTSSRNLASGILRRVDSREVANFPLNIFIYDFLNAELELKTNDLAIAKLKKLGFKVDPLIRFFDQKSSIIEVLNYIADITKKRNSFEYEIDGVVLKVSEFVLREKLGYTSHHPKWAMAYKFEALSGFSRVNSIVVQVGRSGKITPVANIDKVFVSGAFITNATLHNQDYIISIGLNVGDVVKVSRRGDVIPAVEMVINKCSKGVFKVPDNCPACKTVLVKEGAHFFCTNNSCPSVAVERIKYFCSKNCMDIEGFSDKTISFLFEKEFISSEIDLYTFNFYKLLKFKGFKDRKVYNLINSIEASKKKPFSKLLLSIGIKELGENAIRLLFLNNLNSFSKLFRLCQDRNFAFSTLLKIKGIGEKIALNIIEAFNDSTMLNKFKFFENLGFKMEESILIDDENRLLAGKKFCITGTFNGYSRSIIIDKLKNKGAIFKTCVTEGLDFLIVGEKAGSKLEKALNLNVKIMSFEDIKSYLN
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL20_CLOBB
Sequence: MARVKRAKNARKNHKKVLKLAKGYYGGKSKLFKTANESVIRALRNSYVGRKNKKRDYRRLWIARINAATRINGLSYSKFMNGIKLAGIDINRKMLSEIAINDAKAFADLVEVAKKQLNA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: IACG_PESFW
Sequence: MTETVLVIGATGHIGVSAVIGALRTKRNVLAVVRNAAAVDKLFRLAGTRDGITTVEADITSEHGLQSVVDKVKNGELPAFQHVYSAVGGVKTTTPLKDLSIEDFRANMSINFDTNFFAYRATIGYLLSQSNPTTYTVITGAIGDVGIWPGPAMSQGALYSLGISAELENRDTNVRFNEMYLAFPVMVDEEAVKEEAAKMGVVKASDFARSYENLLAKDEIKGSRIFIFTPGDIDTLRWESKAFKGPPS
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of iso-A82775C, a enylepoxycyclohexane and biosynthetic precursor of the chloropestolide anticancer natural products (PubMed:29384350).  Within the cluster, the prenyltransferase iacE prenylates siccayne to generate pestalodiol E, using dimethylallyl diphosphate (DMAPP) as cosubstrate (PubMed:29384350).  The probable oxidoreductase iacF is then involved in the epoxidation of pestalodiol F to pestalodiol F, which is further converted to pestalofone A by the short-chain dehydrogenase/reductase iacG (PubMed:29384350).  Iso-A82775C is subsequently generated from pestalofone A by the short-chain dehydrogenase/reductase iacC (PubMed:29384350).  Iso-A82775C is further condensed with maldoxin via a Diels-Alder reaction to produce the anticancer natural products chloropestolides A to E (Probable).
What are the official names of this protein?
Short-chain dehydrogenase/reductase iacG, Iso-A82775C biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MSCL_BRADU
Sequence: MLKEFREFAMKGNVVDLAVGVIIGAAFGAIVTSLVGDVIMPLIGAVTGGLDFSNYFTPLSKAVTATNLADAKKQGAVLAWGSFLTLTINFIIIAFVLFLVIRAINTLKRKEEAAPAAPPKPSAEVELLTEIRDLLKKS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ST2B1_HUMAN
Sequence: MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS
What is the function of this protein?
Sulfonates pregnenolone but not cholesterol.
What are the official names of this protein?
Sulfotransferase 2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, Sulfotransferase family 2B member 1, Sulfotransferase family cytosolic 2B member 1, ST2B1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus.
Protein: LPXH_HAEIE
Sequence: MKHSYFISDLHLSETQPELTALFVDFMQNLAPQAERLYILGDLFDFWIGDDEQSTLIQQVKDLIKSVSEQGVQCYFQHGNRDFLIGERFAKDTGVQLFPDYQLITLYDKKILLCHGDTLCIDDVAYQQFRRRVHQKWLQRLFLCLPLKVRLKIAEKIRAKSNQDKQAKTQEIMDINQAFTTEKVQEFGVNLLIHGHTHREAIHQQAGFTRIVLGDWRKNYASILKIDESGEFGFIKD
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.