PharMolix/UniProtQA huggingface dataset:
Protein: SAT_ALKCK
Sequence: MEAVKETELVHRYDPAYDTTGITNEIALDGFALSDLELLGIGGFTPLTGFLNEDDYHSVVKSMRLANGAPWSIPISLPVSADQASALRVGERAKLVYKNDIYGVIEIESIYTPDKKVEAQEVYRTTDEAHPGVAKMYARPPIYVGGPIVLTKRVNYERFASYYIDPIDTRRIFAEKGWKTVVGFQTRNPVHRAHEYIQKAALETVDGLFLNPLVGETKAGDIPADVRMESYEVLLKNYYPKNRVHLSVFPAAMRYAGPREAIFHALVRKNYGCTHFIVGRDHAGVGNYYGTYDAQEIFKEFEEGELGIKPLFFEHSFYCKACGNMASQKTCPHDSEHHVILSGTKVRQMLKEGVLPPQEFSRKEVVEVLMRG
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: RL10_RHOP5
Sequence: MEKAAKKEAVESLNGLFKTTSVAVVAHYSGLTVAQMQKLRSQMKLAGASVKVSKNRLAKIALEGTDVVAIGSLLKGPTVIATSNDPVAAPKVAVEFAKANEKFVILGGSMGTTVLNVDGVKALASLPSLDELRAKLVGLLVAPATKIAQLTTAPASKLARVVQAYASKDEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: PRIO_TRAIM
Sequence: MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPSQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHGQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESEAYYQRGASVILFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: PAN_METAR
Sequence: MQTILMAEGSGLDFTGEVPLSDFSKYLLDRVKQLEERNVRLKEEYRKIELEKKSVENKKVQYEREIRKLTSELDRLKTPPLIVGTILDVMANGKMIIKSSTGPKFVVNSSQFINSKEVYPGAKVALNQQSLAVIEVLPTVKDPSVLGMEVVDSPEIDYQSIGGLEAQINELKETVELPLLKPELFQKVGIEPPKGVLLYGPPGTGKTLLAKAVANRTKATFIRIIGSELVQKYIGEGARMVRELFELAKEKSPSIIFIDEIDSIGAKRLDSITSGDREVQRTLVQLLAEMDGFDPRGNVRILAATNRPDILDPALLRPGRFDRMIKVPMPTAEAREQILKIHARKMNLADDVDLRKIALITDESSGADLSAIVMEAGMFAIRNNRDVVDSSDFNAAVAKVMGERNRSMAQESGVMFA
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle.  Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.  Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
What are the official names of this protein?
Proteasome-activating nucleotidase, PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFD_BUCAI
Sequence: MKITKNKILKNKKIINFKYQKLLDLFYNVNNQKKNNQLLSYLYSFSGKIIFSLTEEKSLKKILRFLMRHKIHPQYIKRIIDIKKEIDYFYMIEEIKNGFIDKKNNILFLCTKDLLPILIDDKYIGNIKKNTNNINKFNLSQLILNHPVMHIEHGIGRYKGLTTIETASIQSEYLVISYAEGDKLYVPVSNLHLVSPYTGTSIENAPLHKLGGDDWNKEKHKISKTVYDHAAQLLHIYAKRESKTGFAFKKNIEKYDLFCNDCSFKTTSDQNEVMKFVLKDMSKPIPMDRLICGDVGFGKTEIAMRASFLAVSNKKQVAILVPTTLLAQQHYKNFKIRFSNWPVNINILSRFQTQKEQDLIFKHTKNGRINIIIGTHKLLFKNIEWCSLGLLIIDEEHRFGVSHKEIIKKIYSNIDILTLTATPIPRTLNMAMTGIKDLSIIAKPPAQRLAIKTFIQEYSPILIRKTILREISRGGQVYYIYNKVQNIMNIAERLSILIPEASIKIGHGQMKNIDLKKVMNEFYNNKFNVLICTTIIESGVDIARANTIIIENSDHFGLSQLHQLRGRIGRSNNQAYALLLVNNFNKITSDAKKRLEAISSVDNFGGGFSLSNQDLEIRGVGEILGKEQSGHIKNIGFSLYMDLLKNAIDLLKNGKIFSVEKSLKKPLEIDLHVSSLLPSSYILDINTRLFFYKKLANAIHEKQIEEIKYELIDQFGKLPDFSKNLILIAKIRLIADKIGIKYIKSNNNIGIIEFNDYGSINTEYLLKMFQKEPKIWKMETSTRIKFILHLKNDYLRLKWIINLLRNLFKKNI
What is the function of this protein?
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions.  Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (By similarity).
What are the official names of this protein?
Transcription-repair-coupling factor, TRCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the helicase family. RecG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTA_SHIBS
Sequence: MMVIRPVERSDVSALMQLASKTGGGLTSLPANEATLSARIERAIKTWQGELPKSEQGYVFVLEDSETGTVAGICAIEVAVGLNDPWHNYRVGTLVHASKELNVYNALPTLFLSNDHTGSSELCTLFLDPDWRKEGNGYLLSKSRFMFMAAFRDKFNDKVVAEMRGVIDEHGYSPFWQSLGKRFFSMDFSRADFLCGTGQKAFIAELMPKHPIYTHFLSQEAQDVIGQVHPQTAPARAVLEKEGFRYRNYIDIFDGGPTLECDIDRVRAIRKSRLVEVAEGQPAQGDFPACLVANENYHHFRVVLARTDPATERLILTAAQLDALKCHAGDRVRLVRLCAVEKTA
What is the function of this protein?
Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.
What are the official names of this protein?
Arginine N-succinyltransferase, AST, AOST.
What is the protein family that this protein belongs to?
Belongs to the arginine N-succinyltransferase family.
Protein: NCBP1_DROSE
Sequence: MSRRRAHDTEDEGYDHRRNKRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLGTFRLKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKMCRWDAARYSLRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTLPWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLVFDSILCEALQHNLPTIVPPPHHDNFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHIIETYHHERKDCAAQLLSFPYKHKIPLEYCIVEVVFAELFHMPTPRYLDICYGSILIELCKLQPATLPQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFKFTWSWDEWDSWLLLDGEHPRPKFIQEVLQKCLRLSYHQRITEMMPTTYAKLIPLTPVPNYKYANEEAASLPGTTVAHQLVVAIRQKCTPEEVVNILKDIPNSGYSGEEMSDGSFNALKIDVFVQTLLNLGSKSFSHSFAAISKFHSVFRALAETEEAQICILHNIFELWSSHQQMMVVLIDKLLKLQIVDCSAVATWIFSKEMTGEFTKLYLWEILHLTIKKMNKHVIKLNSELSEAKDKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVERMEEKLEAANVNQKRLFLIVFQRFIMILSEHLLRSDTDGRDPDTDWYRWTIGRLQQVFLMHHEQVQKYSSTLETLLFTSDLDTHILEVFQQFVALRA
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 1, 80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the NCBP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EI2BB_MOUSE
Sequence: MPGAAAKGSELSERIEGFVETLKRGGGQRSSEDMARETLGLLRRLITDHHWNNAGDLMDLIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFSFHFAPLKANIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGYSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKEGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGSLRAVAGTHTLALAAKHHSTPLIVCAPMFKLSPQFPSEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPDLITLFISNIGGNAPSYIYRLMSELYHPDDHVL
What is the function of this protein?
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
What are the official names of this protein?
Translation initiation factor eIF-2B subunit beta, eIF-2B GDP-GTP exchange factor subunit beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family.
Protein: TCPB_BRUME
Sequence: MSKEKQAQSKAHKAQQAISSAKSLSTQKSKMSELERATRDGAAIGKKRADIAKKIADKAKQLSSYQAKQFKADEQAVKKVAQEQKRLSDERTKHEAFIKQSLSSMRTTASATMEAEEEYDFFISHASEDKEAFVQDLVAALRDLGAKIFYDAYTLKVGDSLRRKIDQGLANSKFGIVVLSEHFFSKQWPARELDGLTAMEIGGQTRILPIWHKVSYDEVRRFSPSLADKVALNTSLKSVEEIAKELHSLI
What is the function of this protein?
Virulence factor that interferes with host Toll-like receptor 2 (TLR2) and TLR4 signaling, resulting in the reduction of dendritic cell maturation, inhibition of pro-inflammatory cytokine secretion and impaired NF-kappa-B activation in macrophages.  Interferes with host TLR4 signaling by abolishing host TLR4-TIRAP interaction (but not host TIRAP-MYD88 interaction) and its downstream signaling (PubMed:19196716, PubMed:24265315, PubMed:24275656, PubMed:27311859).  Inhibits host TLR 2 induced NF-kappa-B activation and TNF (tumor necrosis factor) secretion (PubMed:19196716).  Binds phosphoinositide (PtdIns) via its N-terminal domain (PubMed:19196716).  Has NAD(+) hydrolase (NADase) activity, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922).  Also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR (probably 2'cADPR) (PubMed:29395922) (Probable).
What are the official names of this protein?
Probable 2' cyclic ADP-D-ribose synthase TcpB, 2'cADPR synthase TcpB, Brucella TIR-containing protein 1, Btp1, NAD(+) hydrolase TcpB, TIR domain-containing protein in Brucella, TcpB.
Protein: NADK_ECO55
Sequence: MNNHFKCIGIVGHPRHPTALTTHEMLYRWLCTKGYEVIVEQQIAHELQLKNVKTGTLAEIGQLADLAVVVGGDGNMLGAARTLARYDIKVIGINRGNLGFLTDLDPDNAQQQLADVLEGHYISEKRFLLEAQVCQQDCQKRISTAINEVVLHPGKVAHMIEFEVYIDEIFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITLVPMFPHTLSARPLVINSSSTIRLRFSHRRNDLEISCDSQIALPIQEGEDVLIRRCDYHLNLIHPKDYSYFNTLSTKLGWSKKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAO12_VIBVY
Sequence: MSKKMFIRQAGNTLLNTPLLNKGSAFTLEERKNFNLIGLLPANIETIDEQVSRAYEQFSLFNSAMEKHIYLRNIQDTNETLYFRLINQHIEEMMPIIYTPTVGEACQKFSQIYRRNRGLFLSFEDQDELEAILNNAPNTHVKVIVITDGERILGLGDQGIGGMGIPIGKLALYTACGGISPEHTLPIVLDVGTNNSALLSDPMYMGWRHPRITGDQYDDFVDDCLKAIRRRWPNALIQFEDFAQANAMPLLMRYQNQFCCFNDDIQGTASVTVGTLLAAAHATGKKLSAQKVLFAGAGSAGCGIAEAIVAQMVSEGISVQQARSQVFMVDRWGMLEQEMPNLLPFQKPLAQPASLRTEWQIEANREISLLDVIQHAHPDVLIGVTGVPGLFNQEIIEAMAEDCERPVVMPLSNPTSRVEAKPEDILMWTQGQAIVATGSPFPDVVLAGKRYPIAQCNNSYIFPGVGLGVISANAHRVTNEMLQQASITLASLSPMLNGGNMLLPPLSEIQNVSRKIALEVAKKAVEQGKASHRTEERLLERIDEEFWYAQYCEYRRIAS
What are the official names of this protein?
NAD-dependent malic enzyme 2, NAD-ME 2.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: COAD_HELMI
Sequence: MTVAVYPGSFDPITKGHMDIVERAAQIFHEVIVAVVINPNKKPLFTMDERVEMIRMAVSHISNVRVESFSGLLVDFTRKQGARAIVRGLRAVSDFEVEFQMALMNKRLYPEVETVFMATHTDYAFLSSSMVKEVASFGGDVSDYLPPAVLARMAEKYGDTVRGKAPVR
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_HAEDU
Sequence: MAAKIISGINIAKQIKQNIAQKIAQYIVNGYRRPGLAVILVGADPASQVYVNSKRKSCAEIGIESKYYDLPATITEVELLSIIQRLNSDEMIDGILVQLPLPEHINPIHITEAISSDKDVDGFHPYNVGRLCQKIPTLRSCTSYGVMKLLESTHIDLSGLHAVIVGASNIVGRPMAMELLLAGCTVTITHSRTKNLVDHLSSADIVIVGIGHPNFVKGEWLKQGAIVIDVGINRDTYSKKLVGDVDFLTAEAKASFITPVPGGVGPMTVAMLMQNTLQAYEHHLQAV
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RPOB_PLAOC
Sequence: MRRDGNEGMSTIPGFNQIQFEGFCRFIDQGLTEELYKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSEVYVPAGLIWKPGRDMQEQTIFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYRSESDHNGISVYTGTIISDWGGRSELEIDRKARIWARVSRKQKISILVPSSAMGSNLREILDNVCYPEIFLSFLNDKEKKKIGSKENAILEFYQQFACVGGDPVFSESLCKELQKKFFQQRCELGRIGRRNMNRRLNLDIPQNNTFLLPRDVLAAADHLIGMKFGMGTLDDMNHLKNKRIRSVADLLQDQFGLALIRLENVVRGTICGAIKHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQMVHGRKLSYLGPGGLTGRTASFRIRDIHSSHYGRICPIDTSEGINVGLIGSLAIYARIGHWGSLESPFYEISDRSKEVQMLYLSPSRDEYYMVAAGNSLALNQSIPEEQVVPARYRQEFLTIAWEQVHFRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSQSEKCIVGTGLERQAALDSGVSTIAEHEGKIIYTDTDKIILLGNGDTLSIPLVMYQRSNKNTCMYQKPQVRRGKFIKKGQIVADGAATVGGELALGKNVLVAYMPWEGYNSEDAVLISERLVYGDIYTSFHIRKYEIQTHVTSQGPERITNEIPHLEAHLLRNLDRNGIVMLGSWVETGDILVGKLTPQMAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWIQKKGGSSYNPETICVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPIDMVFNPLGVPSRMNVGQIFECSLGLAGDLLDRHYRIAPFDERYEQEASRKLVFSELYKASKQTANPWVFEPEYPGKSRIFDGRTGDPFEQPVLIGKSYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRAKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIVGGTIPSPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLSX_THEAB
Sequence: MKKIAIDLMGGDYAPEEILAGALSFAKENEDVELYLVGIEENFKDVQLPKNCVKVVTDDFLPMDVKPTEAVRRRKSTMYVSCQLAREKKVDAVVSAGNTGALLACATFVVGRIKGIERPTLAVPIPTKNDFCVLADAGANIDVKPSNLLQFAIMGVEYAKLLGKDNPTIGLLNVGTEENKGTQKEKEAFQILKERFGNQFVGNVEGNDLNAGKVDVVVADGFHGNIAMKTMEGAAKMITELIKSEVKKNIISALGALLMKPVFSSLKNKLDPKKYGGTFFIGVEGVVVKAHGNSNRTAIFNALKVAKKGVEEKLPLKIKEALLKCAE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: VE6_HPV16
Sequence: MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: SYH_WOLTR
Sequence: MTNQTVRGTKDLLFDEWYRFKYIQQIANRISSLYGFLPAQTPIFEYTEVFMKTLGDGSDIINKEMYTFYDKGGKSITLRPEFTAAIVRLLVEKKLQIPIKLFSTGPAFRYERPQKGRQRQFHQINFEVFGVENPKADIELISLAHHLLTEFNISKNVRLEINSLGDSETIAKYKEVLIPYFKKFQNDLSEDSQNRLTKNPLRILDSKDEKDKLIISDAPKISDYYTRESSDFFEQILNGLTALNIPCTVNSKLVRGLDYYCHTVFEFVIEDFGAQGAVFAGGRYDNLVSSVGGKYTPAIGFAGGIERIMELINYSMKGDRPICLVPIGREAEEHALTLANELRRNGLYVIYEYNGALKNRMKKASQANAKAALIFGNEELGSKTLKIKNMDTGEEKIIAYGNIMENIHQTLLV
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_SHEB9
Sequence: MSENRIRIATRKSPLAMWQAEFVKAELERIHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLDDLADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQIRASRPDLIIKDLRGNVGTRLAKLDNGEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRINDERVKALLAPLEHLETRYRVLAERAMNTRLEGGCQVPIGAFAEIDGDEMTLRGLVGNPDGSEIIEGVITGPKTDATQLGVALAEELLSKGAKSILDAVYAKA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RECO_PSEF5
Sequence: MSSNAPVGQLAYVLHSRAYRESSALVDFLTPQGRLRAVLRNARGKAGTLARPFVPLEVEFRGRGELKNVGRMESAGIAAWLNGEALFSGLYLNELLIRLLPAEDPHPAVFDHYAATLLALAEGRPLEPLLRAFEWRLLDDLGYGFALDSDIHGAPIAADGLYRLQVDAGLEQVFLLQPGLFNGTELLAMADADWSAPGALSAAKRLMRQALAVHLGGRPLVSRELFRKP
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: PROA_PHOPR
Sequence: MNLEHMGKAAQEAAFELATVATAQKNQALAIIADELEANKDAILAANAKDINAARESGMTDALIDRLLLNEERLTGIANDVRNVISLNDPVGAELDSRVLENGMRLSRRRVPLGVVGVIYEARPNVTIDIAALCLKTGNASILRGGRETFHSNVELVKVIQVALKKADLPAASVQYIEKPDRELVSQLLRLDQYVDMIIPRGGAGLHKMCKENSTIPVIIGGFGISHIYVDHSADISRSIDVVENAKAQRPSACNALDTLLVSEKVAETFLPRLAERLNKSNVEFVADDAAYSFLEGKAATLRHAADGDFDTEWLSFTLGVKVVADVAEAIAHMRKHNASHSDAILTNDIQSAERFVNAAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTSYKWVGQADYLVRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_ECOLI
Sequence: MISDIRKDAEVRMDKCVEAFKTQISKIRTGRASPSLLDGIVVEYYGTPTPLRQLASVTVEDSRTLKINVFDRSMSPAVEKAIMASDLGLNPNSAGSDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKEISEDDDRRSQDDVQKLTDAAIKKIEAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
Protein: Y1180_CORJK
Sequence: MPDHQEGEGRRVTAANRRAVGNLGEDLAAEYLHRAGYEVLDRNFYTRYGELDLVARTPEDDLAFIEVKYRTSASDGGGVAAVGPRKLRRIRTLAGLWLEQNREGVQFSGGLRVDVIDVGPDGVREHVEGVW
What are the official names of this protein?
UPF0102 protein jk1180.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: UVRB_COLP3
Sequence: MKKLTICSEYTPSGDQPTAIKQLLEGIESGLAHQTLLGVTGSGKTYTIANVIEKLNRPTMMLAPNKTLAAQLYGEMKEFFPDNAVEYFVSYYDYYQPEAYVPTTDTFIEKDASVNEHIEQMRLSATKALLERRDVIIIASVSAIYGLGDPDSYLKMMLHISRGDIINQRDILRRLAELQYTRNDVAFARATYRVRGDVIDIFPAESDRLALRVELFDEEIERISQFDPLTGQVERTLDRVTVYPKTHYATPKEKIIAAVDKIKIELKHRSQQLKDNNKLVEEQRLTQRTQFDIEMMTELGYCSGIENYSRYLSGREEGGAPPTLFDYLPDDGLLIIDESHVTVPQIGAMYKGDRSRKENLVEYGFRLPSALDNRPMKFEEFEAISPQTIYVSATPSKFELEKCGSDIAEQVVRPTGLLDPEIEVRPVETQVDDLLSEINKRLPLDERVLATTLTKRMAEDLTDYLYDHGIKARYLHSDVDTVERVEIIRDFRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSDRSLIQTIGRAARNLNGRAILYGDRITGSMRRAIDETERRRVKQHQYNLDNNITPQGVVRRITDVMGVGSYSDAKSLDKVAEANTNYHINQQAEEPLLTTSQIDTKIVELEKLMQGHAQNLEFEQAAAMRDKIAKLRIQQLST
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_STRT2
Sequence: MKRTYQPSKIRRQRKHGFRHRMSTKNGRRVLAARRRKGRKVLAA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.