PharMolix/UniProtQA huggingface dataset:
Protein: LPQY_MYCTU
Sequence: MVMSRGRIPRLGAAVLVALTTAAAACGADSQGLVVSFYTPATDGATFTAIAQRCNQQFGGRFTIAQVSLPRSPNEQRLQLARRLTGNDRTLDVMALDVVWTAEFAEAGWALPLSDDPAGLAENDAVADTLPGPLATAGWNHKLYAAPVTTNTQLLWYRPDLVNSPPTDWNAMIAEAARLHAAGEPSWIAVQANQGEGLVVWFNTLLVSAGGSVLSEDGRHVTLTDTPAHRAATVSALQILKSVATTPGADPSITRTEEGSARLAFEQGKAALEVNWPFVFASMLENAVKGGVPFLPLNRIPQLAGSINDIGTFTPSDEQFRIAYDASQQVFGFAPYPAVAPGQPAKVTIGGLNLAVAKTTRHRAEAFEAVRCLRDQHNQRYVSLEGGLPAVRASLYSDPQFQAKYPMHAIIRQQLTDAAVRPATPVYQALSIRLAAVLSPITEIDPESTADELAAQAQKAIDGMGLLP
What is the function of this protein?
Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose.  Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M. tuberculosis.  Trehalose uptake is essential for virulence (PubMed:21118978).  No binding affinity for maltose (PubMed:35775983).
What are the official names of this protein?
Trehalose-binding lipoprotein LpqY, SugABC transporter substrate-binding protein LpqY, SugABC transporter SBP LpqY.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ZP3_PIG
Sequence: MAPSWRFFVCFLLWGGTELCSPQPVWQDEGQRLRPSKPPTVMVECQEAQLVVIVSKDLFGTGKLIRPADLSLGPAKCEPLVSQDTDAVVRFEVGLHECGSSLQVTDDALVYSTFLRHDPRPAGNLSILRTNRAEVPIECHYPRQGNVSSWAILPTWVPFRTTVFSEEKLVFSLRLMEENWSAEKMTPTFQLGDRAHLQAQVHTGSHVPLRLFVDHCVATLTPDWNTSPSHTIVDFHGCLVDGLTEASSAFKAPRPGPETLQFTVDVFHFANDSRNTIYITCHLKVTPADRVPDQLNKACSFSKSSNRWSPVEGPAVICRCCHKGQCGTPSLSRKLSMPKRQSAPRSRRHVTDEADVTVGPLIFLGKTSDHGVEGSTSSPTSVMVGLGLATVVTLTLATIVLGVPRRRRAAAHLVCPVSASQ
What is the function of this protein?
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy.  The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.  ZP3 is essential for zona matrix formation.  May not have a sperm-binding activity by itself but may increase sperm-binding activity of ZPB.
What are the official names of this protein?
Zona pellucida sperm-binding protein 3, Sperm receptor, Zona pellucida glycoprotein 3, Zp-3, Zona pellucida glycoprotein 3-beta, Zp-3-beta, Zp3-beta, Zona pellucida protein C.
What is the protein family that this protein belongs to?
Belongs to the ZP domain family. ZPC subfamily.
What are the subcellular locations of this protein?
[Processed zona pellucida sperm-binding protein 3]: Zona pellucida. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
Protein: SYS_PARMW
Sequence: MLDQRLVRENPDAIATELGRRGKAVDLTRLQVIAQQQRKLEEERSGLQAEGNRIGKEVGQKIKGGADPKGEEVAELRQQGNAIKQKVAVLEEEEKHLFTQLKEQLLTYPNLPSPDCPEGKDETDNVELRRWGSPRQEEGLEEHWQIAERLHLFDTERSVRIAQSRFVTLMGQGARLERALINFMLDLHTSKGYREVMPPVLVNSASLTGSGQLPKFADDCFRCSEDDLWLTPTAEVPVTSLHRDEIIPADQLPLRYAAYSPCFRREAGSYGRDTRGLIRLHQFNKVELYWFAHPDHSAEAHAQITADAEAVLQALELPYRVLDLCTADIGFSAQRTYDLEVWLPGAEAYREISSCSVCGDFQARRSAIRTKEGKSTKLVHTLNGSGLAVGRTMAAVLETGQQSDGSVLLPKALVPYVGDERLQPE
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_ECO8A
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVLLRDGEAFLFGANITPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRVNREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDIKEREWQVDKARIMKNAHR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RASEF_HUMAN
Sequence: MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNCCNG
What is the function of this protein?
Binds predominantly GDP, and also GTP (PubMed:17448446).  Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157).
What are the official names of this protein?
Ras and EF-hand domain-containing protein, Ras-related protein Rab-45.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: RPIA_ACIF2
Sequence: MNTDALKKMAAEAALRYIQPGMVVGVGTGSTTNFFIEALGAAKIHVDGYVASSIATENRLKAQGLNVLELNATGDIPVYIDGADEADPHFRLIKGGGGALTREKIVASAARLFVCIADDSKDRPMLGKFPLPVEVIPFARSFVARQLVKIGGSPTLRSGITTDNGNVILDVTGLDFSDPLRMEETINAIPGVLDNGIFAHRRADVMLFGSAGGVIERKA
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: KAX6H_OPICY
Sequence: IRCQGSNQCYGHCREKTGCMNGKCINRVCKCYGC
What is the function of this protein?
This toxin reversibly blocks Shaker B potassium-channels (expressed in insect Sf9 cells) with a Kd of 96. 6 nM, and presents an even better affinity toward hKv1. 3 (KCNA3), blocking it with a Kd of 17. 7 nM.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 6.17, Toxin OcyKTx2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 06 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CBID_CITK8
Sequence: MSDQSFDAPVWHNGKALRKGYTTGSCATAAAKVAALMVLRQHLIHQVSIVTPSGVTLCLNVESPHIEGRQAIAAIRKDGGDDVDATHGMLIFARVTLNDSGEITLQGGEGVGTVTRKGIGLPVGSAAINRTPRHTIESVVREAIGPARGADIEIFAPEGEERAQKTYNARLGILGGISIIGTTGIVTPMSEESWKRSLSLELEIKRAAGLERVVLVPGNHGERFVREQMGIDTQVVVTMSNFVGYMIEEAVRLGYRHIVLIGHPGKLIKIAAGIFHTHSHIADARMETLVAHLALLGAPLELLTRVSDCDTTEAAMEHIEAYGFQHIYNHLAQRICMRVMQMLRFTKTPPTCDAIMFSFDNQILGSNRPIEEIVEEMQC
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: DADA_SALCH
Sequence: MRVVILGSGVVGVTSAWYLSQAGHDVTVIDRESGPAQETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAVRLDGTPFQLKWMWQMLRNCDTRHYMENKGRMVRLAEYSRDCLKTLRAVTGIEYEGCQGGTLQLFRTAQQYENATRDIAVLEDAGVPYQLLEASRLAEVEPALAEVAHKLTGGLRLPNDETGDCQLFTQRLARMAEQAGVTFRFNTPVEKLLYENDQIYGVKCADEIIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIVEPDGAPVSTILDETYKIAITRFDKRIRVGGMAEIVGFNTDLLQPRRETLEMVVRDLFPRGGHIEQATFWTGLRPMTPDGTPVVGRTRYKNLWLNTGHGTLGWTMACGSGQLLSDILSGRTPAIPYDDLSVARYRSDFTPTRPQRLHSAHN
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: AAS_SALTY
Sequence: MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTSISQQWYMRWLTPLIDFVPLDPTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDGAGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRIQLHILPPTQIPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTKTLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENSRGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE
What is the function of this protein?
Plays a role in lysophospholipid acylation.  Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium.  Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
What are the official names of this protein?
Bifunctional protein Aas.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLAT_DANRE
Sequence: MPVSKREQSKDTGDPCALPKLPIPPLKQTLDMYLTCMGHLVPEDQFRKTKAVVEKFGAPGGVGETLQKKLLERSEQKANWVYDYWLEDMYLNNRLALPVNSSPVMVFHKQNFKGQSDVLRFAANLISGVLEYKALIDGRALPVEHARGQLAGTPLCMDQYNKVFTSYRLPGTKTDTLVAQKSTVMPEPEHIIVACKNQFFVLDVMVNFRRLNEKDLYTQLERIRKMADIEEERQPPIGLLTSDGRTQWAEARNILIKDSTNRDSLDMIERCLCLVCLDEETATELNDSNRALLMLHGGGTDKNGGNRWYDKPMQFVIGADGCCGVVCEHSPFEGIVLVQCSEYLLRYMRGSPSKLVRAASMSELPAPRRLRWKCSPDIQTFLSASADRLQKLVKNLDMNVHKFTGYGKEFIKRQKMSPDAYVQVALQFTFYRCHGRLVPTYESASIRRFQEGRVDNIRSSTPEALAFVKAMASGSKITDAEKMELLWTAIKAQTNYTILAITGMAIDNHLLGLREIAKELKLEKPELFSDTTYATSIHFTLSTSQVPTTEEMFCCYGPVVPNGYGACYNPQTDHILFCVSSFRECAETSSDLFVKTLEGCLKEMQDLCRKCNTEVKPADSTQRMEGNPKVMKNGSKS
What is the function of this protein?
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
What are the official names of this protein?
Choline O-acetyltransferase, CHOACTase, ChAT, Choline acetylase.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
Protein: PUR9_ALISL
Sequence: MNNPRPIRRALISVSDKTGIVEFAQALTERGVDILSTGGTARLLAEKNIPVTEVSDYTGFPEMMDGRVKTLHPKVHGGVLGRRGQDDGIMEQHGINPIDIVVVNLYPFAETVAKEGCTLADAVENIDIGGPTMVRSAAKNHKDVTIVVNAHDYDRVIAEMDTNDKSLTQATRFDLAIAAFEHTASYDGMIANYFGTMVPSYGENKEGDNESKFPRTFNQQFEKKQDMRYGENSHQAAAFYVEANPEEASVSTARQIQGKALSYNNIADTDAALECVKEFNEPACVIVKHANPCGVALGKDVLEAYHRAYQTDPTSAFGGIIAFNRELDAATATAITERQFVEVIIAPSVSAEAIEIIAAKKNLRLLECGEWSTKTTEFDIKRVNGGLLVQDRDQGMVSEDELEVVSKRQPTAEELKDALFCWKVAKYVKSNAIVYSKGDMTIGVGAGQMSRVYSAKIAGIKAADEGLVVEGCAMASDAFFPFRDGIDAAAEAGIKCVIQPGGSMRDDEVIAAADEHGMAMIFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: TKNK_HUMAN
Sequence: MRIMLLFTAILAFSLAQSFGAVCKEPQEEVVPGGGRSKRDPDLYQLLQRLFKSHSSLEGLLKALSQASTDPKESTSPEKRDMHDFFVGLMGKRSVQPDSPTDVNQENVPSFGILKYPPRAE
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity).  Is a critical central regulator of gonadal function.
What are the official names of this protein?
Tachykinin-3, ZNEUROK1.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YIDD_BURL3
Sequence: METVLIALLRFYKVAVSPMLGNRCRFYPSCSDYAREAIQYHGAARGTYLAVRRVCRCHPFSAGGIDLVPPPNSDTRARGEADARSHRL
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HTR1_HALMA
Sequence: MTISSVKQSYGAKLGVGYIATATLLITVGVVTQDVASTVVAGIAGLLTLGSINAAETVASITELSAQTQRVADGDLDIEIDSTRTDEFGDLADSIEQMRVSLRDRLSEMEAARADLEQAQTDANEAQAEAEAAEEEAKELATAYQDIATEYGTVMAAAADGDLTQRVDVATEYDAMETVGQSFNRMMDELQETIETVTAVSKRITTETDEITETSRRVQQEVDAAVETVADIQTQATDQQTKLESAAVDIQDVSASAEEIAATIDDLADRSSEVEEASSDARTASETALTEMDQIQADAADAVTQVETLQQRMAEITDIADIISEIAEQTNMLALNASIEAARAGGQGSGADGNGFSVVADEVKSLAEETQSRADEIATVIAEVSEQTEEVTDSIQATETRVETGTETVESALSEIATIAEAVDDISASIEEMRETTSEQADTVQATADSIADVTEASAETATTAEEMSTQIRRQRDVVKSISDSLDSFRETAVDDLESRVRLFTINTDTTAASQTRAVGSPSIGGDD
What is the function of this protein?
Transduces signals from the phototaxis receptor sensory rhodopsin I (Sop1).
What are the official names of this protein?
Sensory rhodopsin I transducer, MCP domain signal transducer 1, HmHtrI.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GPDA_LACLM
Sequence: MNPQKIAVLGPGSWGTALSQVLNDNGHEVRIWGNNLEQMAEINEKHTNTRYFKDVVLDEKIKAYSRLDLALENVDAILFVVPTKVTRLVAKQVAQVLKHKVHILHASKGLEQGTHDRISTILEEEIPAQLRGEIVVVSGPSHAEETIVRDITLISAASNDHDEAKYAQSIFSNDYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAIITRGLAEITRLGVAMGAEPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGEKIADIEKNMGMVIEGVSTTKAAYELAQRLEIDMPITETIYKVLYENLDAKSGILDIMRRETRAENEFININK
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3127_MYCTO
Sequence: MLKNAVLLACRAPSVHNSQPWRWVAESGSEHTTVHLFVNRHRTVPATDHSGRQAIISCGAVLDHLRIAMTAAHWQANITRFPQPNQPDQLATVEFSPIDHVTAGQRNRAQAILQRRTDRLPFDSPMYWHLFEPALRDAVDKDVAMLDVVSDDQRTRLVVASQLSEVLRRDDPYYHAELEWWTSPFVLAHGVPPDTLASDAERLRVDLGRDFPVRSYQNRRAELADDRSKVLVLSTPSDTRADALRCGEVLSTILLECTMAGMATCTLTHLIESSDSRDIVRGLTRQRGEPQALIRVGIAPPLAAVPAPTPRRPLDSVLQIRQTPEKGRNASDRNARETGWFSPP
What are the official names of this protein?
Uncharacterized protein MT3212.
Protein: Y3093_PELPD
Sequence: MPSFDIVSKVDMQEVDNAVNQAVKEISQRYDFKGSKSEISQEKDAVRVLADDDFKLKAVIDVLQSKFLKRNISIKALQYGKVEPASGGMVRQLISVQQGISKEKGKEIIAVIKESKLKVQAQIQDDQVRVTGKNRDDLQGAIQLLKGKDLDIEMQFVNFRE
What are the official names of this protein?
UPF0234 protein Ppro_3093.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: MECA2_BACAN
Sequence: MRLERLNYNKIKIFLTFDDLSERGLTKEDLWRNAPKVQQLFRDMMQEANKELGFEADGPIAVEVFSLQAQGMVVIVTKEHQEADTDDEFRDEFIEMQVTLDESEHILYEFATLDDVINLSNRLYNLDVTGGKLYTWDGRFYLWMEEEEQIQLLKADFIAILAEYGNPSTATIYRLMEYGKELMASQAIEQIHNYFVKKQNLS
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.  Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease.  When overexpressed, inhibits sporulation.  Also involved in Spx degradation by ClpC (By similarity).
What are the official names of this protein?
Adapter protein MecA 2.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: SYL_ALKCK
Sequence: MSFSHQEIEKKWQAFWEENKTFKTDEQAEGPHFYALDMFPYPSGAGLHVGHPEGYTATDILARMKRMQGYNVLHPMGWDAFGLPAEQYALDTGKHPATFTKQNIDTFKRQIKELGFSYDWDREISTTDPHYYKWTQWIFLKLYEKGLAYIDEVAVNWCPALGTVLANEEIVDGVSERGGHPVERRPMKQWVLRITAYAERLLEDLEELEWPESLKDMQRNWIGKSEGAEVTFKINEHSVNVFTTRPDTLFGATYMVLAPEHKLVTEITTDEQKEAVEAYQKQVALKSDIERTDLAKEKTGAFTGAYAINPVNGEKIPVWIADYVLISYGTGAVMAVPAHDERDFEFANAFGLPIKEVVAGGDVSKAAYTGDGEHVNSDFLNGLNKQEAVEKMIVWLEENGAGQRKVTYRLRDWLFSRQRYWGEPIPIIHWEDGSMSALDESELPLVLPDLEEIKPSGTGESPLANAKDWLEVVDPKTGMRGRRETNTMPQWAGSCWYYLRYIDPTNDEALADPEKLKNWLPVDTYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKVFNQGMILGENNEKMSKSKGNVVNPDEIIASHGADTLRLYEMFMGPLDASVAWSTNGLDGSRRFLERVWRLIVNEETGKLNSNVKDVEGNEAFVRTYHQTVKKVTEDFAELRFNTGISQLMVFVNEGNKQEVLPKALIEGFVKLLSPVAPHIAEELWEKLGHTDTITYEAWPTYDESLLVENEVEVVVQMNGKVKTKLVINKGASKEEMEAAALADEKVQAAIGEKTIRKVIAVPGKLVNIVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARAB_SALG2
Sequence: MAIAIGLDFGSDSVRALAVDCATGDEIATSVEWYPRWQEGRYCDGPNNQFRHHPRDYMESMEAALKAVLAQLSAAQRANVVGIGVDSTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEADEITRLCHKPGKVDYSRYIGGIYSSEWFWAKILHVTRQDSAVAQAAVSWIELCDWVPALLSGTTRPQDIRRGRCSAGHKTLWHESWGGLPPASFFDELDPCINRHLHYPLFSETFTADLPVGTLCAEWAQRLDLPESVVISGGAFDCHMGAVGAGAQSNTLVKVIGTSTCDILIADKQSVGDRAVKGICGQVDGSVVPNFIGLEAGQSAFGDIYAWFSRVLSWPLEQLAAQHPELKTQINASQKQLLPALTDAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPALFGGLVASTAFGARAIQECFTEQGIAVNNVMALGGIARKNQVIMQVCCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPAAQQSMASAVERTLRPRPEQAQRFERLYRRYQQWALSAEQHYLPTAAPAPTTPANQAILTH
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: AER3_AERHY
Sequence: MKKLKITGLSLIISGLLMAQAQAAEPVYPDQLRLFSLGQEVCGDKYRPVNREEAQSVKSNIVGMMGQWQISGLANGWVIMGPGYNGEIKPGSASSTWCYPTNPATGEIPTLSALDIPDGDEVDVQWRLVHDSANFIKPTSYLAHYLGYAWVGGNHSQYVGEDMDVTRDGDGWVIRGNNDGGCDGYRCGDKTSIKVSNFAYNLDPDSFKHGDVTQSDRQLVKTVVGWAINDSDTPQSGYDVTLRYDTATNWSKTNTYGLSEKVTTKNKFKWPLVGETELSIEIAANQSWASQNGGSPTTSLSQSVRPTVPAHSKIPVKIELYKADISYPYEFKADVSYDLTLSGFLRWGGNAWYTHPDNRPNWNHTFVIGPYKDKASSIRYQWDKRYIPGEVKWWDWNWTIQQNGLPTMQNNLAKVLRPVRAGITGDFSAESQFAGNIEIGAPVPVAAASHSSRARNLSAGQGLRLEIPLDAQELSGLGFNNVSLSVTPAANQ
What is the function of this protein?
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death.  The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter.
What are the official names of this protein?
Aerolysin-3, Hemolysin-3.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane. Note=Secreted as a soluble precursor.
Protein: SYC_PARDP
Sequence: MVEIRLTNTRTRRKEVFRPIDPQNVRLYLCGPTVYDRAHLGNARPVVVIDVLVRLLRHLLGADHVTYVRNFTDVDDKINATALARKEAGTPGTLEELIRERTHETIGWYHADMDALGAERPDHEPRATDYIGEMIAMIETLIAGGHAYARDGHVLFRVRSYADYGKLSGRSVDDMIAGARVEVAPFKEDPMDFVLWKPSDDELPGWDSPWGRGRPGWHIECSAMSYELLGESFDIHAGGIDLQFPHHENEIAQSCCAHPHGDFARVWLHNEMLQVEGRKMSKSLGNFFTVRDLLDQGIPGEVIRFVLLSTHYRKPMDWTAEKAREAEAVLRRWRGLVAGVEPAPGPAPAVVAALADDLNTAGAIAALHEMAGQGDGPGLLAGARMLGLLTEDLGGWIAEGPDLSALTERMAALRADAKASKDFSAVDALKQRLLDAGVEVRMSAAGVELLPGPDFDAAKLPE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_MESH2
Sequence: MPENLEIRPSSFENFIGQKKLVETLQILISSSQKRKQSLDHILFYGPPGTGKTTLANIVANVLEAKIKYVQGPLLEKKSDVLAVLANISPDTIIFIDEIHGINKNIEELLYSAMEEFVIDLQIGVDGERKIMRMKLPQFTLIGASTKLAQISTPLQNRFGYVAKIVDYTLEDMIQIIRNSSAVLKLKMNTEIIKYIASFSNNTPRIANNLLKRIRDFALVLNAKRIDKDIVNKTFDSIGIYNQGLSQINIEYLNLLVKIFKGKSVALDVIANVLKEHRQTIINIIEPPLIEKELIEKTSRGRRITKKGRDYLLELKTN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NIJA_DROME
Sequence: MSNLEHITLEMDKVPLGDNKTLVRNTENISKHSYGGAIDGRTRNTLRVPRAVPETDDDDNDDRPFVKDGNDNPGVDDGLFSTVGGNGGNGGNVNVNVPNGGRRPSFSFPGYNGPGFVTINGVETPIPDVNAYQHKKTLAQGMMDLALLSANANQLRYVLETSSQHPYFYPSLLFISLSIIFQIAVGVGLILNGQYNIKNGHDICRANRINNYTVSGIFIVTVVNVLISAFTVDRDTVPALPANTT
What is the function of this protein?
Secreted form generated by cleavage, which acts as a negative regulator of cell adhesion (PubMed:16815999).  Promotes the loss of cell adhesion in a cell non-autonomous manner (PubMed:16815999).
What are the official names of this protein?
Ninjurin-A, dNINJ-A.
What is the protein family that this protein belongs to?
Belongs to the ninjurin family.
What are the subcellular locations of this protein?
[Ninjurin-A]: Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Secreted ninjurin-A]: Secreted.