PharMolix/UniProtQA huggingface dataset:
Protein: GRDC_PEPAC
Sequence: MNFPVLKGAGYVLVHTPDMIMHNGTTQTTEKIVNPESEYLKKLPEHLRSFEDVVAYAPNQTYIGSMTPEALGEIAMPWWTEDKKVAGADRYGKLGEIMPQDEFLALMSASDVFDLVLFEKEFIEGAKAKLAAHPVVGNLAESVNAGVELAEIEKQLSEFHAEGLYNNGKLVGCVKRAHDVDVNLNSHTMLENLAVKASGVLALANLIAKNNVNPAEVDYIIECSEEACGDMNQRGGGNFAKALAEMTGCVNATGSDMRGFCAGPTHALIAAAALVKSGVYKNVIIAAGGATAKLGMNGKDHVKKEMPILEDCLGGFAVLVSENDGVNPILRTDLVGRHTVATGSAPQAVIGSLVLSPLKAGGLKITDVDKYSVEMQNPDITKPAGAGDVPEANYKMIAALAVMGKEIERADIAAFVEKHGMVGWAPTQGHIPSGVPYIGFAISDLTEGSVNRTMIVGKGSLFLGRMTNLFDGVSIVAERNTGKVESGSSVSTEEIRKMIAESMKDFAAHLLAE
What is the function of this protein?
In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate.  Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine.  By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state.  Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.
What are the official names of this protein?
Glycine/sarcosine/betaine reductase complex component C subunit beta, Protein PC beta.
Protein: TPRN_HUMAN
Sequence: MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENPFMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRAAEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAPGPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAGSPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIRPAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGPASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPPPFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPARPLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF
What are the official names of this protein?
Taperin.
What is the protein family that this protein belongs to?
Belongs to the taperin family.
What are the subcellular locations of this protein?
Cell projection, stereocilium. Note=Localized prominently at the taper regions of hair cell stereocilia.
Protein: IF1A_SULIN
Sequence: MPKKDRAQEAPSRDVPKPEEGQTICVVKKMLGGDHLVVLCMDGKERLARIPGKIRKKMWMREGDVVLVGIWDFQPNRCDILYKYGNDEIKRLVNENIISREVIDQLRG
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
What are the official names of this protein?
Translation initiation factor 1A, aIF-1A.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: SYGB_STRSY
Sequence: MTKNLLVELGLEEIPAYIVTPAMHQLRDRMATFLTDNRLAFDSIDVFSTPRRLAVRVRGLADQQTDLTEDFKGPAKKIALDADGNFTKAAEGFVRGKGLTTADIEFREIKGEEYVYVTKHEAGQPAKTVLAGIPEVLKAMTFPVSMNWASNKFAYIRPVHTLTVLLDDEALDMDFLDITSGRISRGHRFLGNETEIASADSYEADLRAQFVITDPAERQNMIVEQIKAIEDKHNVTVEIDEDLLNEVLNLVEYPTAFMGSFDTKYLEVPEEVLVTSMKNHQRYFVVRDKAGKLLPNFISVRNGNDQYLDNVIKGNEKVLVARLEDGEFFWREDQKLKIADLVERLKVVTFHEKIGSLYEHMERTKVIAEKLADLAGLSAGEKADVARAADIYKFDLLTGMVGEFDELQGIMGEKYALLAGEKPAVAAAIREHYLPNSAEGELPESKVGAVLALADKFDTLLSFFSVGLIPSGSNDPYALRRATQGIVRILEAFGWEIPLDQLIAELYSLNFASLTYDNQPAVMDFIRARVEKMMDKTIPKDIREAVLASSTFVVRLQLAASSAIFQKAKEADYKEAVENLSRVFNLAEKAEVTAIDEALFENDQEKALAAAVAGLELTEDMAGNLDKLFALSPVIAAFFDNTMVMVDDATVKANRLALLKALADKASAVAVFNLLNSK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_LARHH
Sequence: MTQSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGGLGGFGALVEISKKYREPVLVSGTDGVGTKLKLAFDWNRHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVAQATDVIKGIAEGCEQAGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKSQVITGRDIRPGDVVLGLGSNGVHSNGFSLVRKIIERAGPDLDAPFDGDRTLRDAIIAPTRIYVKPLLKLMAGVPVKGMAHITGGGITENTPRVLPDNCVAQIDAASWTLPKLFQWLQQEGNVDAQEMYRTFNCGIGMVVIVAPEQADAATALLTAEGETVHRLGLVRARQGDEHQTQIA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CST9_YEAST
Sequence: MGGYLAIVFIPQTNTKSMREKKQKCLKQVRRLSLISPKKYIMPDSIFEQPFVYCGVCHRRTSHGDPLRLTSCAHILCSQHSPLTSKVCPICRSSDISIINLVESKQLPTDIRIFFEPLPPLLESLYNVSQFQLNGLSKQCQYYQNHCLKLREKCARQQQLLYQAKIELDSMAILKKRIQELESVLNHNNVSSMSVGVLPTRNSHQNHYQPPPTVDLTVDDNSLEEFEAKSFIKKLKKNSSLRNSSKNNNGTVTPSTSGRVNKNQPLFMETLNNPNRNSIPPPGMNPNANSNLPNISTIAESTNLNRFSFSPVRVAKGFDGKLPNLDILTNNGSVSSKNISRLSSASLQPSSPLSSSSNRLILPNSNLKELHHSNTPLTSTSTQFPSALEKLKITRKRNNTISGSNRITHNLSSHVRSSGLAFSSSSNSLQQSKLPKSNILKRSNSTQQLTNTHLKSDNHLPPRSSNTVLGSSKKNNKFRRIR
What is the function of this protein?
Component of the synapsis initiation complex (SIC) necessary for the synaptonemal complex assembly.  Stabilizes the ZIP2 component to the chromosomes.  The SIC complex loads onto chromosomes and nucleates ZIP1 polymerization, a molecular zipper that acts to bring homologous chromosomes in close apposition, which is required for meiotic crossover.  May also be involved in double strand break repair.
What are the official names of this protein?
Chromosome stability protein 9, Molecular zipper protein 3.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Synapsed meiotic chromosomes.
Protein: DPOD3_CHICK
Sequence: MEDELYLENIDEFVTDQNRIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVTYLVAGNLIQNGHTCHKVAVVREDKLEAMKSKLATVTSVHVYSIQKALLKDSGPLYNTDYDIIKANLHNCSKFSAIRCADAVPRTPAEVAQARTLARSSSQTPSDTSAVSTPPLNGHGPTAAKQSSQPPKGIMGMFAAKAASKAQDANKEPKAKEAPSVSAASSKPSAKGNIMNNFFGKAAMNKLKVNSVPGQPKEEKEAVKTSVPATEPESSPNTIVEKPGRKTEPAKIQQKDKKSKMKRMDKSDNEEEREPENQKKKRKRIKQLESDSSDEEDVLASPTLEEEKAPSPPPLVPALKAELEPASTEASAGGKKRKRKRVLKSKMFVDEEEGCMVTEKVYESESCTDSEDDFAKTKPPAVPKQPALPVKKEPKEERKNQKKGAATASRANKQISIMGFCQKK
What is the function of this protein?
Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex.  As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair.  Required for optimal Pol-delta activity.  Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA.  Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4.  They exhibit differences in catalytic activity.  Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4.  Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides.  Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated.  Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation.  In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites.  Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR).  Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH).  Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion.  Also involved in TLS, as a component of the tetrametric DNA polymerase zeta complex.  Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7.
What are the official names of this protein?
DNA polymerase delta subunit 3, DNA polymerase delta subunit p66.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Partially colocalizes with PCNA and POLD1 at S phase replication sites. Recruited to DNA damage sites within 2 hours following UV irradiation.
Protein: YEEX_SALDC
Sequence: METTKPSFQDVLEFVRLFRRKNKLQREIQDIEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKSDYEDRVDDYIIKNAEISKERRDISKKLKAMGEMKHADVKAE
What are the official names of this protein?
UPF0265 protein YeeX.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: P2C14_ORYSJ
Sequence: MVEAAAGRRSGANRRRPSGGGERRRQQQQHQRLVAVAVAARVVMVAPAATPAPAAGGGGGCVEDILGCLLGVLRALGVTWAAAARPQRQQPRLAAQTPRGPAPGADGRRAAAELRGIPGRIAGNGACAVASLYTLQGKKGVNQDAMIVWENFCSREDTIFCGVFDGHGPNGHLVAKRVRDLLPIKLGADLGTDEGRQTSTSSIKSNGDETGSPGNMGRDAEQNGEYPEIFTALRTSFLRAFNVMDRDLKLHKSIDCFFSGTTAVAVLKQGRNLIIGNLGDSRAILGTRDKDNQLMAVQLTVDLKPNIPSEAQRIRQRRGRIFALPEEPEVARVWLPKYNSPGLAMARAFGDFCLKDYGLISMPEVSYHRITEKDEFVVLATDGVWDVLSNTEVVSIVNRATSRASAARLLVESAHRAWRARFPTSKIDDCAVVCLFLDTDELSETSSSMARDMTNAVEVSSGQHSNTIQLSTGVSSDVVTAVLTDGDDLSAVDAVAKLVTLTDLPNNASGATQSITTK
What are the official names of this protein?
Probable protein phosphatase 2C 14, OsPP2C14.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: RSMF_ALIF1
Sequence: MHDNIFLPDAFLAQVQETMPSYLSMDEFIAACKRPLRRSIRVNILKNSVEEFKQRAAEKQWDLEPVPWCDTGFWITRPESDTVKLGSTAEHMAGLFYIQEASSMMPVTALLKDNDDIEMALDMASAPGSKTTQLAAGMKNQGALVANEFSSSRVKVLCSNIQRCGVSNVALTHFDGRVFGGWLPETFDSILLDAPCSGEGTIRKDPDAMHNWSPESVIEIGDTQRDLIESAFHALKLGGVMVYSTCTLNHEENQNICHHLVEQFGDAVTFEPLGDLFESAEKALTKEGFLHIYPQIFDSEGFFVAKIRKNSSTTPPEVKKRLGKFPFAPASNKEAQAIEAELKSTLQLAIPEDNEFWIRDKEVWAFPKRMKPLIGEMRYHRIGFKLAETHKKGYRWQHEAIMALATADNPTCAELNTEQAREWYMGRDVRPDFSGKGETIVTYKGAVIGLGKWVGNRIKNGLPRELVRDGNLF
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPIKE_CVPFS
Sequence: MKKLFVVLVVMPLIYGDNFPCSKLTNRTIGNHWNLIETFLLNYSSRLSPNSDVVLGDYFPTVQPWFNCIHNNSNDLYVTLENLKALYWDYATENSTWNHKQRLNVVVNGYPYSITVTTTRNFNSAEGAIICICKGSPPTTTTESSLTCNWGSECRLNHKFPICPSNSEANCGNMLYGLQWFADAVVAYLHGASYRISFENQWSGTVTLGDMRATTLETAGTLVDLWWFNPVYDVSYYRVNNKNGTTVVSNCTDQCASYVANVFTTQPGGFIPSDFSFNNWFLLTNSSTLVSGKLVTKQPLLVNCLWPVPSFEEAASTFCFEGAGFDQCNGAVLNNTVDVIRFNLNFTTNVQSGKGATVFSLNTTGGVTLEISCYNDTVSDSSFSSYGEIPFGVTDGPRYCYVLYNGTALKYLGTLPPSVKEIAISKWGHFYINGYNFFSTFPIDCISFNLTTGDSDVFWTIAYTSYTEALVQVENTAITKVTYCNSYVNNIKCSQLTANLNNGFYPVSSSEVGFVNKSVVLLPTFYTHTIVNITIGLGMKRSGYGQPIASTLSNITLPMQDNNIDVYCIRSDQFSVYVHSTCKSALWDNVFKRNCTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLSPVGANCKFDVAARTRANDQVVRSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRSGVGIIRQTNRTLLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAVIDGTIVGAITSINSELLGLTHWTTTPNFYYYSIYNYTNDMTRGTAIDSNDVDCEPVITYSNIGVCKNGALVFINVTHSDGDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCSRYVCNGNPRCNKLLTQYVSACQTIEQALAVGARLENMEVDSMLFVSENALKLASVEAFNSSETLDPIYKEWPNIGGSWLEGLKYILPSDNSKRKYRSAIEDLLFSKVVTSGLGTVDEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAIPFAVAVQARLNYVALQTDVLNKNQQILASAFNQAIGNITQSFGKVNDAIHQTSRGLATVAKALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAHVDRLITGRLTALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCGNGTHLFSLANAAPNGMIFFHAVLLPTAYETVTAWAGICALDGDRTFGLVVKDVQLTLFRNLDDKFYLTPRTMYQPRVATSSDFVQIEGCDVLFVNATLSDLPSIIPDYIDINQTVQDILENFRPNWTVPELTFDIFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKWPWYVWLLIGLVVIFCIPLLLFCCCSTGCCGCIGCLGSCCHSICSRRQFENYEPIEKVHIH
What is the function of this protein?
S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection.  Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion.  S2 region belongs to the class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the alphacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly.
Protein: KAE1_ASPCL
Sequence: MIAIGLEGSANKLGVGIMLHPEDGSTPQVLANIRHTYVSPPGEGFLPKDTARHHRAWVVKLVKRALREARVSVDDVDCICFTKGPGMGAPLQSVAVAARTLSLLWGKELVGVNHCVGHIEMGRLITGSTNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKKGKQLVDLPYTVKGMDCSFSGILAAIDGLAASYGLNGKEKEEEEKLVALSDPATSEAVENVKPTRADLCFSLQETIFSMLVEITERAMAHVGSKEVLIVGGVGCNERLQEMMGIMARDRGGSVHATDERFCIDNGIMIAQAGMLAYKTGFRTPLTESTCTQRFRTDGVFVKWRD
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein kae1, tRNA threonylcarbamoyladenosine biosynthesis protein kae1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATPA_XANOP
Sequence: MATTLNPSEISDLIKTRIEAVKLSAESRNEGSVTSVSDGIVRIFGLADVMQGEMIELPNNTFALALNLERDSVGAVVLGDYENLREGDVAKTTGRILEVPVGPELLGRVVNALGEPIDGKGPLGATQTAPVERVAPGVIWRKSVDQPVQTGYKSVDAMIPIGRGQRELVIGDRQTGKTALAIDAVINQKGTGIKCVYVAIGQKASTVANIVRKLEENGALAHTVVVAATASESAAMQYISPYAGCTMGEYFMDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAYPGDVFYLHSRLLERAARVSEDYVEKFTNGAVTGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGIRPAVNAGISVSRVGGAAQTKIIKKLSGGIRISLAQYRELAAFAQFASDLDEATRKQLERGQRVTELMKQKQYAPMSIANQALSIYAVNEGYLDDVPVNKLLAFEEGLHAHFANTQGELVSKINSTGGWDNDIEASFKKGIQEFKTTGTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NUOB2_RHOPA
Sequence: MTMTPQHPGMPDEQRSVEEHMALSSLFTTLEDLTAWSRKHSLWPFNFGLSCCYVEQVTVLTPVYDQARFGAEVIRASPRQADLLVVSGTVFHKMAAPLLRLYEQMRAPRWVIAMGACACSGGMYDIYSVVQGVDRFIPVDVYIPGCPPRPEAVLDALIMLQQQVGSERRPLGVTVGNTAGLGFDAPRRRDQRRDERMAQTLLDPPESL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 2, NADH dehydrogenase I subunit B 2, NDH-1 subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TXA1_LATTR
Sequence: MSKLFFVVFLCLIISVFAISPADIGCTDISQADFDEKNNNCIKCGEDGFGEEMVNRCRDKCFTDNFYQSCVDLLNKVYEEKDTPPVQE
What is the function of this protein?
May increase the toxicity of alpha-latrotoxin and/or other venom components.  Is non-toxic to mice and to the cockroach Periplaneta americana.
What are the official names of this protein?
Alpha-latrotoxin-associated low molecular weight protein, Alpha-latrotoxin-associated LMWP, Latrodectin-1, Latrodectin.
What is the protein family that this protein belongs to?
Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
What are the subcellular locations of this protein?
Secreted.
Protein: CH60_PSEPG
Sequence: MAAKDVKFGDSARKKMLVGVNVLADAVKATLGPKGRNVVLAKSFGAPTITKDGVSVAKEIELKDAFENMGAQLVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKATAAVVAELKNLSKPCADSKAIAQVGTISANSDDSIGNIIAEAMEKVGKEGVITVEEGSGLENELSVVEGMQFDRGYLSPYFVNKPDTMVAELEGPLLLLVDKKISNIRELLPVLEAVAKAGRPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAVLTGGQVISEEIGLSLETATLEHLGNAKRVILSKENTTIIDGAGADTEIEARVKQIRAQIEETSSDYDREKLQERLAKLAGGVAVIKVGAGTEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALVRALAAIVDLKGENEDQNVGIALLRRAVEAPLRQITANAGDEPSVVADKVKQGSGNFGYNAATGEYGDMIEMGILDPAKVTRSALQAAASIGGLMITTEAMIADAPSEAPAGGGMPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLTB_PROMU
Sequence: MGRFIFVSFGLLVVFLSLSGTAADCPSDWSSFRRYCYQVFQQKMNWEDAEKFCTQQHRGSHLVSFHSSEEVDFVVSKTLPILKANFVWMGLSNVWNECAKEWSDGTKLDYKAWSGQSDCITSKTTDNQWLSMDCSSKRYVVCKF
What is the function of this protein?
Snaclec that induces platelet aggregation in either human platelet rich plasma (PRP) or washed platelet suspensions.  It causes aggregation in a dose-dependent manner even in the absence of various platelet agonists such as ADP or von Willebrand factor (vWF).  Interestingly, it does not induce aggregation in rabbit PRP.  A monoclonal antibody against the platelet GPIb receptor blocks the aggregation induced by trimecetin, suggesting that it acts by binding to GPIb (GP1BA/GP1BB).
What are the official names of this protein?
Snaclec trimecetin subunit beta.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: CAV1_MUNMU
Sequence: MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMAEEMNEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLFEAIGKIFSNIRINMQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: RL19_CERS5
Sequence: MNLIAQLEAEQIAALGKTIPDFKAGDTVRVGYKVTEGTRSRVQNYEGVVIGRKGGNTISASFTVRKISFGEGVERVFPLYSTNIDSIEVVRRGRVRRAKLYYLRSRRGKSARIAEVTNYKEKSE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: AM2A5_MOUSE
Sequence: MKFVLLLSLIGFCWAQYDPHTSDGRTAIVHLFEWRWVDIAKECERYLAPKGFGGVQVSPPNENVVVHNPSRPWWERYQPISYKICTRSGNEDEFRDMVTRCNNVGVRIYVDAVINHMCGAGNPAGTSSTCGSYLNPNNREFPAVPYSAWDFNDNKCNGEIDNYNDAYQVRNCRLTGLLDLALEKDYVRTKVADYMNHLIDIGVAGFRLDAAKHMWPGDIKAVLDKLHNLNTKWFSQGSRPFIFQEVIDLGGEAIKGSEYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGLVPSDRALVFVDNHDNQRGHGAGGSSILTFWDARMYKMAVGFMLAHPYGFTRVMSSYRWNRNFQNGKDQNDWIGPPNNNGVTKEVTINADTTCGNDWVCEHRWRQIRNMVAFRNVVNGQPFSNWWDNNSNQVAFSRGNRGFIVFNNDDWALSATLQTGLPAGTYCDVISGDKVDGNCTGLRVNVGSDGKAHFSISNSAEDPFIAIHADSKL
What are the official names of this protein?
Pancreatic alpha-amylase 2a5, PA, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: ARGC_PSEAB
Sequence: MIKVGIVGGTGYTGVELLRLLAQHPQARVEVITSRSEAGVKVADMYPNLRGHYDDLQFSVPDVQRLGACDVVFFATPHGVAHALAGELLDAGTRVIDLSADFRLADAEEWARWYGQPHGAPALLDEAVYGLPEVNREKIRQARLIAVPGCYPTATQLGLIPLLEAGLADASRLIADCKSGVSGAGRGAKVGSLFCEAGESMMAYAVKGHRHLPEISQGLCRASGGDVGLTFVPHLTPMIRGIHATLYAHVADRSVDLQALFEKRYADEPFVDVMPAGSHPETRSVRGANVCRIAVHRPQGGDLVVVLSVIDNLVKGASGQALQNMNILFGLDERLGLSHAALLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.