PharMolix/UniProtQA huggingface dataset:
Protein: TIG_BACP2
Sequence: MSVKWEKQEGNEGVLTVEVDAETFNKALDDAFKKVVKQVSIPGFRKGKVPRGLFEQRFGVESLYQDALDILLPVEYPKAIDEAGIDPVDRPEIDVEKIEKGESLIFTAKVTVKPEVKLGDYKGLNVEKDDATVTDEDVQEELKGMQNRQAELVVKEEGAIENGDTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEEQLVGLEAGAEKDVEVTFPEEYHAEDLAGKPAVFKVKIHEIKAKELPALDDEFAKDVDEEVETLAELTEKTKKRLEEAKENEAEGKLREELVEKASENAEVDIPQAMVDTELDRMMKEFEQRLQMQGMNLELYFQFSGQDEDALKEQMKEDAAKRVKSNLTLEAIAAAENLQVSDEEVEEELSKMAEAYNMPIENIKQAIGSTEAMKEDLKVRKAIDFLVENR
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: REXO4_MOUSE
Sequence: MCACAVAGVAVSSLVVPTAESGEMKTKATAPVPQPGPIRKLARKKAKKKFRKSKALAGSGVPGSHPAAVAGRPPKAPENFSQNWKALQELLKQKSQAAEKPLVSQMDDKMHPQIIQQNRKKASDKSKGDKQRTEKAKSTRGSVTSAPTDRKILVPPTDTSGTEQKKGAKKRTYSDISSHQGALKPKWKATEAAVILNQPTPTEEDIWFDDVDPDDIEDAIGPEAAMLVRKRLGQKKRTISLEKEQAFGGLTKALALDCEMVGVGPKGEESIAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPENLKQGEEFEVVKKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKFKPFRSRVKSGRPSLKRLSEKILGIRVQQAEHCSIQDAQAAMRLYVMVKREWESSTANRRAPAATPQHRIKNS
What is the function of this protein?
May function as an exonuclease.
What are the official names of this protein?
RNA exonuclease 4, Exonuclease XPMC2, Prevents mitotic catastrophe 2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the REXO4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: FCHO1_MOUSE
Sequence: MSYFGEHFWGDKNHGFEVLYHCVKQGPVATKELADFIRERANIEETYSKAMAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLHDLLKDVLRYGEEQLKTHKKCKEEVLGTVDAVQMLSGVGQLLPKSRENYLSRCMDLERLRRENTSQKEMDKAETKSKKAADSLRRSVDKYNSARADFEIKMLDSALRFQAMEEAHLQHMKALLGSYAHSVEDTHVQIGQVHEEFKQNVENVTVDMLLRKFAESKGTGREKPGPLDFDAYSSAALQEAMKRLRGAKAFRLPGLSRREPRASVDFLESDSGVPPEVDDEGFTVRPDISQNNGAEPPRFSSSDSDFDDEEPRKFYVHIKPAPTRAVACSSEAAAAQLRATAGSLILPPGPGGTMKRHSSRDTSGKPQRPRSAPRTGSCAEKPLASEEPLSKSLFGPPLESAFDHDDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPESWVPRPGTPQSPPTCRAQHPEPRGLMPRAPSPGPWGPEGGADSLTPADPTREGLAATLRRPRSRKVSCPLTRSNGDLCRSLSPSPLGSSAPTIPPDRPSFSTQMGHGISRGPSPVVLGSQDALPVATAFTEYVHAYFRGHSPSCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVNTAPVEHFQPNADLIFSDPSQSDPETKDFWLNMAALTEALQHQAEQNPTASYYNLVLLRYQFSRPGPESVPLQMSAHWQCGPTLTRVSVEYSYRAGATAVSTPLTNVQILLPVGEPVTSVRLQPAATWNTEEKRFTWKLPDVCEAGGSGHLSASWQPQSGPSTPSPVAAQFTSEGATLSGLDLELLGGGYRMSLVKRRFATGMYLVSC
What is the function of this protein?
Functions in an early step of clathrin-mediated endocytosis.  Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits.  May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.  Involved in the regulation of T-cell poliferation and activation.  Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation.
What are the official names of this protein?
F-BAR domain only protein 1.
What is the protein family that this protein belongs to?
Belongs to the FCHO family.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to it may also dynamically associate with Golgi/TGN membranes.
Protein: SYE_STRPQ
Sequence: MSKPIRVRYAPSPTGLLHIGNARTALFNYLYARRHGGTFIIRIEDTDRKRHVEDGERSQLENLKWLGMDWDESPETHENYRQSERLALYQQYIDQLLAEGKAYKSYVTEEELAAERERQEAAGETPRYINEFIGMSADEKAKYIAEREAAGIVPTVRLAVNESGIYKWADMVKGDIEFEGGNIGGDWVIQKKDGYPTYNFAVVVDDHDMQISHVIRGDDHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRKKGYMPEAVFNFIALLGWNPGGEEEIFSREQLIALFDENRLSKSPAAFDQKKMDWMSNEYLKHADFETVYALCKPFLEEAGRLTEKAEKLVELYKPQLKSADEIIPLTDLFFSDFPELTEAEKEVMAGETVSTVLQAFKAKLEAMSDEDFKPENIFPQIKAVQKETGIKGKNLFMPIRIAVSGEMHGPELPNTIYLLGRDKSIEHIKNML
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KI21B_MOUSE
Sequence: MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEEQGIIPRAIAHLFRGIDERKRRAQEKGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTSRLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGLPDGAAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGTEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARNPYSLGASPAGPAFGGSPATSMEDASEVIRKAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQAENSEETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQQEIVLRRKTQEVSALRRLAKPMSERVAGRVGLKPPNMDSGAEVSASTTSSEAESGARSVSSIVRQWNRKIDHFLGDRPTATVNGGRPARKKFQKKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKREHLQAESPEEEKGLQELAEEIEVLAANIDYINDSITDCQATIVQLEETKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMTGSSQNHLLLDALREKAEAHPELQALIYNVQHENGYASTDEEVSEFSEGSFSQSFTMKGSTSHDDFKFKGEPKLSAQMKAVSAECLGPPLDSSTKNITKSLASLVEIKEDGVGFSIRDPYYRDKVSRTVSLPTRGSTFPRQSRGATDTSPLTRRKSYDRGQPIRSTDMGFTPPSSPPTRPRNDRNVFSRLTSNQSQGSALDKSDDSDSSLSEVLRGIITPIGGAKGARTAPLQCISMAEGHTKPILCLDATDELLFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSSSYIKVWDIRDSAKCIRTLTSSGQVISGDACIATSTRAITSAQGEHQINQMALSPSGSMLYVASGNAVRIWELNRFQPIGKLTGHIGPVMCLTVTQTSNQHDLVVTGSKDHYVKMFQLGDCVTGTIGPTHNFEPPHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFVPGRPMLLSACRAGFIKVWNVDNFTPIGEIKGHDSPINAICTNSKHIFTASSDCRVKLWNYVPGLTPCLPRRVLAIKGRAPPCPDLPPPPLTLPILPFPVFPPPRSELLLHVT
What is the function of this protein?
Plus-end directed microtubule-dependent motor protein which displays processive activity (PubMed:27117409, PubMed:10225949).  Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation (PubMed:27117409).  Plays a role in lerning and memory (PubMed:27117409).  Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface (PubMed:25172774).
What are the official names of this protein?
Kinesin-like protein KIF21B, Kinesin-like protein KIF6.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, dendrite. Cell projection, growth cone. Cell projection, axon. Cytoplasmic vesicle.
Protein: SYE_CHLL2
Sequence: MVAQRVRTRFAPSPTGYLHVGGLRTALYNYLFAKKMKGDFIIRIEDTDQSRKVEDAQQNLIKTLEWAGIVADESPVHGGSFGPYVQSERLHIYREYCDRLLEDKHAYYCFSTSEELEENRQLQLKQGLQPKYNRKWLPEEMGGAMPSSNIRKKMAEGSPYVVRMKVPDYISVWFEDMIRGPVEFDSSTIDDQVLMKSDGFPTYHFASVIDDHLMEFTHIIRGEEWLPSMPKHLLLYEFFGWEPPKFAHLPLLLNPDRSKLSKRQGDVAVEDYIRKGYSCDAIVNFVAMLGWNEGEGTEQEVYALQELIDKFSLERVGKAGAVFNVEKLNWLEKQYIKHRPAADIINTIRPVLASELAKRETLLSVDVITGDHYLEQVIELMRERVGFEHEFVTFSSYFFFEPESYEEEAVKKRWIPETNDLLREFTAELEVLEPFTAETIESALKAFVAPKGLKAAVLIHPLRILASGVSFGPSLYHMLEVLGREAVLRRITKGIEQISVAE
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T23O_POLSJ
Sequence: MCPHAHPPAKPDHGATTTPERIVHDEKAQLDFSRDMSYGDYLQLDAILNAQKPLSPAHDEMLFIIQHQTSELWMKLMLHELRAAIANVAADELGSAFKMLARVSRIMEQLVHAWDVLATMTPPEYSAMRPYLGASSGFQSYQYRCIEFALGNKNAAMLQPHAHRSDLLAQVQAAYEAPSLYDEALRLLARRGLAVPASHTERDWTQPYLESAAVEQAWLTVYRDPKQYWDLYQLGEELTDLEDAFRLWRFRHVTTVERIIGFKPGTGGTSGVSYLRKMLDVVLFPEIWKLRTDL
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: IF1_POLNA
Sequence: MAKEELIEMHGLVDEVLPDSRFRVTLDNGHKLVAYTSGKMRKNHIRILAGDQVSLELSPYDLSKGRITFRHIAGRGPGPAPRQSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUPA_MARN1
Sequence: MSERSVYMVLSPRFSVRAVSLAVAAVSASLSMPTSASMGNLGTSYGVMPVDVATAQSLSMFNEQVSATYYNPAALTKDPRGELTAGILHSEQELRSDNPNASGDIVSDSPSQHVLIGMKTNLGSLTRFGHPIYLGFIAGVEKYGKEMLAFSSETSESGQFLQYGKEPLFLNIGGATPIWRGISAGASVRVTLEATANLDAVSTLGGETSRERLAVNAEPSLKTILGTNIDLGSTFCPESDCFLNGWETALTYRTKSSASTTVDSNIIVTQTIPDPGLSLAVTTIDSFQPETIAIGTQYSGDGWRIGGSIEQQNWSELEDEFSGDSIKDQGSVASGNRIGFDDILIPRLGAEYQLNKNFAVRGGVAYEESPLKTTRNPELNYLDTDKLVVGLGISATYDRTRLLAYPVRLDLGYQYQQLQERDFTVVDYDGDETSVTADGDIHVFSGSITLKF
What is the function of this protein?
Required for growth on alkanes.  Probably involved in the uptake of micelle-solubilized alkanes.
What are the official names of this protein?
Alkane uptake protein A.
What is the protein family that this protein belongs to?
Belongs to the OmpP1/FadL family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: PSBM_CITSI
Sequence: MEVNILAFIATTLFVLVPTAFLLIIYVKTVSQSD
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS7_XANAC
Sequence: MSRKGSTPQRTVLPDPKHGSETIARFINMVMQSGKKSVAEKIVYGAMDVIGEKNPNAIELVQKALDNVAPAVEVKSRRVGGATYQVPVEVRSSRRMALAMRWLIDSARKRGENTMPRKLAAELLDASESRGGAIKKREETHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RL21_CHRSD
Sequence: MYAVIKSGGKQYRVQEGQTLKLEKLEVATGETLELDQVLLVADDDDVKVGAPLVEGAKVTAEVVSHGRGEKVKIIKFRRRKHQMRRQGHRQWFTEVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: SYP_PSEU2
Sequence: MRTSQFLLATQKETPSDAVVVSHQLMLRAGMIRKLASGLYTWLPMGLRVLRKVEAIVREEMDAAGALEILMPGIQPAELWQESGRWEQYGPELMRLVDRHNREFCLGPTHEEVITDLARNELNSYKQLPINMYQIQTKFRDEIRPRFGLMRGREFVMKDAYSFHADHESLQVTYDRMHLAYSNIFTRLGLKFRPVEADNGSIGGAGSHEFHVLAESGEDDIVFSDGSDYAANIEKAEAIPREKTRPAATEELRLIDTPNTKTIAQLVEGFGLPIEKTVKTLVVHAAEEGKLIALIIRGDHELNEIKASQLEQVANPLVMASEAELRDAIGAGAGSLGPLNLPLPCIIDRSVELMSDFSVGANIDDKHYFGVNWERDLPVPTVADLRNVVAGDPSPDGKGTLEIKRGIEVGHIFQLGTKYSEAMKCQVLGENGKPVNLAMGCYGIGVSRVVAAAIEQNSDENGIIWNDTLAPFQIALVPLRYETDAVREATDKLYADLTAAGFEVLLDDRDKKTSPGIKFADMELIGIPHRIVVSDRGLAEGNLEYKSRTESQPQAIAVADVLSFIQGKVNR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUP_CAMFF
Sequence: MIFIDACFGKPTPYTPIWMMRQAGRYLPEYMAVRDAAGDFLSLCKDYKKASEVTLQPVDILGVDAAIMFSDILVVPLEMGMELKFIKGEGPVFENPILSMDSLDKLSVEKAVKNLSYVYDTIKLTREKLSSDKALIGFCGAPWTIATYMIEGGSTKTYNISKKMLYDNPQFLHAILRKVTNALKLYLEEQIKAGVNAVQIFDSWASALEQNAYLEFGFSYINELVDYIKSQYPDIPVIVFPKGISGFLNKIGGKFDVFGVDWSTPLKMAKETLGSRYVLQGNMEPTRLYSKDAIDDGVDEILSIMRGHRHIFNLGHGILPDVPVENAKYFIKSVQEKSAKYCK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAY_YERP3
Sequence: MNDSEFHQLADQLMLYIEETLDGFTGDSDIDYETNGGVMTLTFENGSKIVINRQEPLHQVWLATKAGGYHFNYRDGHWYCSRSGEEFFAKLSEAATTQAGEEVSFSE
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: FAT3_CAEEL
Sequence: MVVDKNASGLRMKVDGKWLYLSEELVKKHPGGAVIEQYRNSDATHIFHAFHEGSSQAYKQLDLLKKHGEHDEFLEKQLEKRLDKVDINVSAYDVSVAQEKKMVESFEKLRQKLHDDGLMKANETYFLFKAISTLSIMAFAFYLQYLGWYITSACLLALAWQQFGWLTHEFCHQQPTKNRPLNDTISLFFGNFLQGFSRDWWKDKHNTHHAATNVIDHDGDIDLAPLFAFIPGDLCKYKASFEKAILKIVPYQHLYFTAMLPMLRFSWTGQSVQWVFKENQMEYKVYQRNAFWEQATIVGHWAWVFYQLFLLPTWPLRVAYFIISQMGGGLLIAHVVTFNHNSVDKYPANSRILNNFAALQILTTRNMTPSPFIDWLWGGLNYQIEHHLFPTMPRCNLNACMKYVKEWCKENNLPYLVDDYFDGYAMNLQQLKNMAEHIQAKAA
What is the function of this protein?
Can function as a Delta(6) fatty acid desaturase.  Introduces a double bond in the fatty acid chain 6 carbons away from carboxy terminal to biosynthesize polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes).  Acts on a variety of substrates such as linoleoyl-CoA ((9Z,12Z)-octadecadienoyl-CoA, C18:2n-6) and alpha-linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA, C18:3n-3) to produce gamma-linolenoyl-CoA ((6Z,9Z,12Z)-octadecatrienoyl-CoA, C18:3n-6) and (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA (18:4n-3) respectively (PubMed:9480865, PubMed:11972048).  Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity).  Plays a role in synaptic vesicle recycling by regulating synaptojanin unc-26 localization at synapses (PubMed:18094048).
What are the official names of this protein?
Delta(6)-fatty-acid desaturase fat-3, FAT-3, Delta(6)-fatty-acid desaturase, Ceeld6, Fatty acid desaturase 3.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ISPG_PROMM
Sequence: MSATMAEYQSSTSRRYDTQIHRRVTRTVNVGGVLIGSDHPVRVQSMINEDTLDVEGATAGIRRLHEAGCEIVRLTVPSLGHAKAVGEICQRLRETYQPVPLVADVHHNGMKIALEVANHVDKVRINPGLFVFDKADPDRTEFSGEEIASIRERIAENFEPLVTRLKQQDKALRIGVNHGSLAERMLFAYGDTPLGMVESAMEFVRICDSLDFHNIVISMKASRAPVMLAAYRLMADTMDQEGFNYPLHLGVTEAGDGDYGRIKSTAGIATLLAEGLGDTIRVSLTEAPEKEIPVCYSILQSIGLRKTMVEYISCPSCGRTLFNLEEVVQKVRDSTSHLVGLDIAVMGCIVNGPGEMADADYGYVGKGPGVISLYRGRDEIRKVSESEGVDALIQLIKDDGRWVDPP
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: ADPGK_CAEEL
Sequence: MFSETFVPSIFSYKHRLLHLSVLFFIVPYWYSYYNDQHRLSSYSVETAMFLSWERAIVKPGAMFKKAVIGFNCNVDLIVSGVRVVDALNTTCSEGKDQETLETLADLHQTFAHFFQRGAAAERYMSSEDQFNLLVAESEASTRSHHHIGGNAALMADRIAANFPSTEVYLVGPIGPRSQALLHPSVKRTNSTRILKDELHVILEYKQGEILGDWVAPSSSRFITSHDHFSGSMVVMEMFFKAIAQFRPDLVVITGVHLLEFQSKEMRQEKMRLIKRNLLQIPPKVPIHLELGSLADEIFSTDVINKILPYVDSLGINEQELTFLSHIANGPHMEEYPVQAGTVHVHKVVEMLHWLLKTYGRDPTGQIASKTGYRLSRIHFHCLTYHIMVSSGTDWSNLAAGLAAGARIAGRLSCNIGANTMDSELLEIRTPANFVLDKKIEKNYQFEAHNPIASWMREDVLFVFTPVLVCRLPSKTVGIDDAISATGLLYSQFYRLNRPTHW
What is the function of this protein?
Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor.  GDP and CDP can replace ADP, but with reduced efficiency (By similarity).
What are the official names of this protein?
Probable ADP-dependent glucokinase, ADP-GK, ADPGK.
What is the protein family that this protein belongs to?
Belongs to the ADP-dependent glucokinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDF4_HUMAN
Sequence: MSKTFVKSKEMGELVNTPSWMDKGLGSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHMETHLLHLKPQVFKSLGESSFGSHLPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKSYSFMPHYPSSSLSSGHVHSTPFQAGTPRYDVPIDMSYDSYPHHGIGTQLNTVFTE
What is the function of this protein?
Probably acts as a transcriptional activator.  Mediates neuronal differentiation.  Required for the regulation of amacrine cell fate specification in the retina (By similarity).
What are the official names of this protein?
Neurogenic differentiation factor 4, NeuroD4, Class A basic helix-loop-helix protein 4, bHLHa4, Protein atonal homolog 3, ATH-3, Atoh3.
What are the subcellular locations of this protein?
Nucleus.
Protein: YABA_STAAW
Sequence: MDRNEIFEKIMRLEMNVNQLSKETSELKALAVELVEENVALQLENDNLKKVLGNDEPTTIDTANSKPAKAVKKPLPSKDNLAILYGEGFHICKGELFGKHRHGEDCLFCLEVLSD
What is the function of this protein?
Involved in initiation control of chromosome replication.
What are the official names of this protein?
Initiation-control protein YabA.
What is the protein family that this protein belongs to?
Belongs to the YabA family.
Protein: PTR27_ARATH
Sequence: MESKGSWTVADAVDYKGRPADKSKTGGWITAALILGIEVVERLSTMGIAVNLVTYLMETMHLPSSTSANIVTDFMGTSFLLCLLGGFLADSFLGRFKTIGIFSTIQALGTGALAVATKLPELRPPTCHHGEACIPATAFQMTILYVSLYLIALGTGGLKSSISGFGSDQFDDKDPKEKAHMAFFFNRFFFFISMGTLLAVTVLVYMQDEVGRSWAYGICTVSMAIAIVIFLCGTKRYRYKKSQGSPVVQIFQVIAAAFRKRKMELPQSIVYLYEDNPEGIRIEHTDQFHLLDKAAIVAEGDFEQTLDGVAIPNPWKLSSVTKVEEVKMMVRLLPIWATTIIFWTTYAQMITFSVEQASTMRRNIGSFKIPAGSLTVFFVAAILITLAVYDRAIMPFWKKWKGKPGFSSLQRIAIGLVLSTAGMAAAALVEQKRLSVAKSSSQKTLPISVFLLVPQFFLVGAGEAFIYTGQLDFFITQSPKGMKTMSTGLFLTTLSLGFFVSSFLVSIVKRVTSTSTDVGWLADNINHGRLDYFYWLLVILSGINFVVYIICALWFKPTKGKDSVEKENGKGFSVEDC
What is the function of this protein?
Low-affinity proton-dependent nitrate transporter.  Not involved in dipeptides transport.
What are the official names of this protein?
Protein NRT1/ PTR FAMILY 6.2, AtNPF6.2, Nitrate transporter 1.4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y363_MYCPN
Sequence: MKFKYGATLFSGFLGLSAILAACGAKGKFDQVDDGKIVLASSLTSKNAANALQAVVEKYNQVKGGNDYPIEITQITGGYDGGRGNLQTKLSVKDKTTFYNLI
What are the official names of this protein?
Uncharacterized lipoprotein MPN_363.
What is the protein family that this protein belongs to?
Belongs to the MG185/MG260 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: KAT3_HUMAN
Sequence: MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS
What is the function of this protein?
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others.  May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.  Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro).  Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).
What are the official names of this protein?
Kynurenine--oxoglutarate transaminase 3, Cysteine-S-conjugate beta-lyase 2, Kynurenine aminotransferase 3, Kynurenine aminotransferase III, KATIII, Kynurenine--glyoxylate transaminase, Kynurenine--oxoglutarate transaminase III.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: RS2_BUCAI
Sequence: MEIVSMREMLKAGVHFGHQTRYWNPKMKPFIFGIRNRVHIINLEKTLPMFHFALSELKKIALKKGRILFVGTKKAASKGIKEVAINCEQFYVNHRWLGGMLTNWKTVRQSIKRLKDLEIESKDGTFSKLTKKEALIRSRELFKLENSLGGIKNMGGLPDCLFVIDAAHENIAITEANNLGIPVFSIVDTNSNPDGVDYIIPGNDDAIRSVNLYLKSIMLTISKINNQNSLDKVFIDTKNSTNIE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.