PharMolix/UniProtQA huggingface dataset:
Protein: RRF_STAA2
Sequence: MSDIINETKSRMQKSIESLSRELANISAGRANSNLLNGVTVDYYGAPTPVQQLASINVPEARLLVISPYDKTSVADIEKAIIAANLGVNPTSDGEVIRIAVPALTEERRKERVKDVKKIGEEAKVSVRNIRRDMNDQLKKDEKNGDITEDELRSGTEDVQKATDNSIKEIDQMIADKEKDIMSV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_PSEPK
Sequence: MTTLMVQGTTSDAGKSTLVTALCRWLLRQGVAVVPFKPQNMALNSAVTADGGEIGRAQAVQAQACRLQPHTDMNPVLLKPNSDTGAQVIIHGRAVTSMNAVAYHDYKTTAMQAVLASHHRLSAAYPVVMVEGAGSPAEINLRAGDIANMGFAEAVDCPVILVADINRGGVFAHLVGTLELLSTTEQARVKGFVINRFRGDIALLQPGLDWLEQRTGKPVLGVLPYVTDLHLEAEDGIDVRQGVKHERVLKVIVPVLPRISNHTDFDPLRLHPQVDLQFIGPGQPIPAADLIILPGSKSVRGDLAQLRERGWDKAIERHLRYGGKLIGICGGLQMLGREVHDPLGLEGAAGSSQGLGLLDYATVLEAEKQLRNVAGTLSLEAATVTGYEIHAGVTTGPALAQPAVQLADGRHDGAVSADGQILATYLHGLFEGSQSCAALLRWAGLEDVQVIDYEALREHDIERLADLVEKHLDTVQLRQLCGVA
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: RS8_CALS8
Sequence: MYVIDPIADMLTRIRNANNARHEVVDIPASKMKKAIAQILLEEGFIKEYEIIDDGKNGIIRIKLKYGPNKERAITGLKRISKPGRRVYAGKDELPKVLGGLGIAIISTSKGIMTDKKARKEGVGGEVLCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: Y268_CAUVC
Sequence: MKDLGGLMKQAQAMQQKLADAQARLAETTVDGTSGGGMVTVTLMGNGELVRVLMDESLVQPGEGEVIADLIIAAHADAKKKLDAKQAQMMQDAAGPMAGLMGGLPGMKF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein CC_0268.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DEOC_BACCR
Sequence: MNIAKLIDHTILKANTTKEDVMKVIEEAKEYKFASVCINPPWVKLAADELAGHDVDVCTVIGFPLGASTTETKAFETKDAIAKGATEVDMVINVGALKDGDNELVEKDIYEVVQAAKGKALVKVIIETCLLTDEEKVRACELSVKAGADFVKTSTGFSTGGATAEDIALMRKTVGPNVGVKASGGVRTREDADKMVAAGASRVGASASVAIVLNDAKGATDNY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUR8_DROSE
Sequence: MNLCSSGATASTTSLSSTGQAERSGGVPGGGAEGGGGGGGSGNSGGGGKTSDVSAEASTLCFAGGSGTAGAITGTDELSNANSPANGAGGASGSTGSAQQPTGSNGHSHLHNENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRDEGIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPSVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRRLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQIDCYYQYELQTVNQAPGAGGNGGGGAAAAGGSASRSSDRR
What is the function of this protein?
Acts as a Ras effector and participates in MAPK pathway activation.  Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation (By similarity).
What are the official names of this protein?
Leucine-rich repeat protein soc-2 homolog, Protein Sur-8 homolog, Protein soc-2 homolog.
What is the protein family that this protein belongs to?
Belongs to the SHOC2 family.
Protein: KR198_HUMAN
Sequence: MSYYRSYYGGLGYGYGGFGGWGYGYGCGYGSFRRLGYGCGYGGYGFSCCRPLYYGGYGFSAFY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 19-8.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 19 family.
Protein: VATO_BOVIN
Sequence: MTGLVLLYSGVFVAFWACLLVVGICYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD
What is the function of this protein?
Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32764564).
What are the official names of this protein?
V-type proton ATPase 21 kDa proteolipid subunit c'', V-ATPase 21 kDa proteolipid subunit c'', Vacuolar proton pump 21 kDa proteolipid subunit c''.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase proteolipid subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Multi-pass membrane protein.
Protein: PORC_PYRHO
Sequence: MIEIRFHGRGGQGAVTAANILAEAAFLEGKYVQAFPFFGVERRGAPVTAFTRIDEKPIRIKTQIYEPDIVVVLDPSLLETVDVTAGLKEEGIVIINTEKSKDEILEKLKKKPKKLALVDATTIALETLGLPITNTAILGAVAKATGLVNIESVEKAIKDTFSGELGEKNAKAAREAFEKTEIFEV
What are the official names of this protein?
Pyruvate/ketoisovalerate oxidoreductases common subunit gamma.
Protein: TRPB_MANSM
Sequence: MTDTILDPYFGEFGGMYVPEILIPVLKQLEKAFVEAQQDPAFQTEFLDLLKNYAGRPTALTLCRNLTKGTKTKLYLKREDLLHGGAHKTNQVLGQILLAKRMGKTRIIAETGAGQHGVATALACAMLGMPCRIYMGAKDVERQSPNVFRMRLMGAEVFPVTKGSSTLKDACCEAMRDWAANYENTHYLIGTAAGPHPFPTIVREFQKMIGEETKAQILQREGRLPDAVIACVGGGSNAIGMFTDFINETSVRLIGVEPAGKGIETGEHGAPLGHGKPGIYFGMKSPIMQTEDGQIEESYSISAGLDFPSVGPQHAYLNSIGRAEYPSITDDEALEAFKELAQHEGIIPALESSHALAYALKMARQNPMREQLLVVNLSGRGDKDIFTVDKIFSERGML
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: LEU1_ACIET
Sequence: MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFESVQAIARAVKDSTVCSLARANDRDIARAAEALKEANRARIHTFIATSALHMEKKLRMTPEQVLEQARQAVRFARNLVEDIEFSPEDGYRSDPDFLCRVIETVIAEGATTINVPDTVGYAIPELYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDVGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVQLESEGEINVAFAKFKELADRKSEIFDEDILALVSDESVTSEKEQFGFVSLAQHSETGERPEATIVFTVDGKEVRSSAEGNGPVDASMKAIEAHVRSGAEMVLYSVNAISGSTESQGEVTVRLQSAGRVVNGVGADPDIVVASAKAYLSALNKLQSKAERVAAQG
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: TM39B_RAT
Sequence: MGGRRGPNRTSYYRNPLCEPGSSGASGGGHSSSASVSSVRSRSRTTSGTGLSSPPLAAQTVVPLQHCKIPELPVQASILFELQLFFCQLIALFVHYINIYKTVWWYPPSHPPSHTSLNFHLIDFNLLMVTTIVLGRRFIGSIVKEASQRGKVSLFRSILLFLTRFTVLTATGWSLCRSLIHLFRTYSFLNLLFLCYPFGMYIPFLQLNYDLRKTNLFSHVASMGPREAVSGLARSRDYFLTLRETWKQHTRQLYGPEAMPTHACCLSPSLIRNEVEFLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKNTHYYDKRWSCELFLLVSISTSVILMQHLLPASYCDLLHKAAAHLGCWQKVDPALCSNVLQHPWTEECMWPQGVLVKHSKNVYKALGHYNVAIPSDVSHFRFHFFFSNPLRILNILLLLEGAVIVYQLYSLMSSEKWHQTISLALILFSNYYAFFKLLRDRLVLGKAYSYSASPQRDLDHRFS
What is the function of this protein?
May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase.
What are the official names of this protein?
Transmembrane protein 39B.
What is the protein family that this protein belongs to?
Belongs to the TMEM39 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RIMP_PSEU2
Sequence: MHEGVQVSSKLEQLQDLLAPVVVALGYQCWGIDFSSQGKHSVLRIYIDKEGGVLVDDCAIVSRQISGVLDVEDPISTEYTLEVSSPGMERPLFTIEQFASYAGEQVKIKLRSPFEGRRNFQGLLRGVEEQDVVVQVEDHEFLLPIDMIDKANIIPTFD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD47_MOUSE
Sequence: MKAFYAFCVVLLVFGSVSEAKFDDFEDEEDIVEYDDNDFAEFEDVMEDSVTESPQRVISTEDDEDEATVELEGQDESQEGDFEDADTQEGDTESEPYDDEEFEGYEDKPDTSSNKNKDPITIVDVPAHLQNSWESYYLEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNSHRELLESNFTLVGDDGTNKEATSTGKLNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMRPVSDQVQIKVTMNDEDMDTYVFAVGTRKALLRLQKEMQDLSEFCSDKPKSGAKYGLPDSLAILSEMGEVTEGMMDTKMVHFLTHYADKIESVHFSDQFSGPKIMQEEGQPLKLPDTKRTLLFTFNVPGSGNTYPKDMESLLPLMNMVIYSIDKAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKKLEKKQMKMKQIKVKAM
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity).  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity).  Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity).  Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity).  Involved in the regulation of calcium ion homeostasis in the ER (By similarity).  Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity).  Has an essential role in the maintenance of ER organization during embryogenesis (PubMed:25009997).
What are the official names of this protein?
PAT complex subunit CCDC47, Adipocyte-specific protein 4, Calumin, Coiled-coil domain-containing protein 47.
What is the protein family that this protein belongs to?
Belongs to the CCDC47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane.
Protein: RL15_UREP2
Sequence: MQLHNLEYKKGSRNHKEKRVGRGHGSGLGKTSGRGQDGQKARKSGMVRLAFEGGQTPLYRRVPKVGFNNDRFANKYNVVTLISLVKYETKELTVEFMYANKIAKNEDLPIKVIGNAVLPSGTVVSAHKFSKGALESISNSKAKAQILE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PLSX_EXIS2
Sequence: MILAVDAMGGDHAPRAIVEGVVQFLAERPTEQIEIRLVGDELKLRSYDIKDPRVKIVHAASVITGEDEPVRAIRRKKDSSLVVAANLVKSNEADALISAGNTGALMTAGLFVIGRIEGIDRPALAPTFPTRNGKGVVILDVGANPDAKAEHLLDYAIMGSVYAEQVRGIKQPKVALLNIGSEAGKGNALTKETYPLLETAPIHFVGNVEAREAMSGEVDVIVTEGFAGNTLLKSTEGAASMIMGVMKEQFMSSFSSKIAALILKPKLKKMKQLLAYEEYGGAGLFGIAAPVIKAHGSSNAYAFSRALVQAEQMVEQQVVTKIIEAKKTKEI
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: PURA_DICDI
Sequence: MASIIIGSQWGDEGKGKLVDILSQQFDVVARCQGGANAGHTIVVDGKKIALHLIPSGILNEKASCILGNGMVIHLPTFFKEVQGLQDKGINYKGRLFVSDRAHLVFDLHQMIDAMKEAELSNGTSNDSIGTTKRGIGPCYSSKASRGGLRVCDLYSPEHFRKTFTRLVENKHKRFGSFEYDVEAELKRYQEFAEMLKPFVIDSVYYLNQAFKDGKKVLIEGAQSTMLDLDFGCYPYVTSSASSVGGACTGLGISPNKVVTQIGVVKAYTTKVGSGPFPTEQNDHVGDSLRKAGSEFGTTTGRPRRIGWLDAVVLRYTSMINDFTRLNLTKLDVLSDFEEIKIGVDYKYKGETIKSFPASLETLAQCEVVYESFPGWKCDLSHVTEYDQLPIQAKNYIKRIEELVGVPIVYIGVGVERKNLIERKELI
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_STRA5
Sequence: MSKTYHFIGIKGSGMSALALMLHQMGHNVQGSDVDKYYFTQRGLEQAGVTILPFSPNNISEDLEIIAGNAFRPDNNEELAYVIEKGYQFKRYHEFLGDFMRQFTSLGVAGAHGKTSTTGLLAHVLKNITDTSFLIGDGTGRGSANANYFVFEADEYERHFMPYHPEYSIITNIDFDHPDYFTGLEDVFNAFNDYAKQVQKGLFIYGEDPKLHEITSEAPIYYYGFEDSNDFIAKDITRTVNGSDFKVFYNQEEIGQFHVPAYGKHNILNATAVIANLYIMGIDMALVAEHLKTFSGVKRRFTEKIIDDTVIIDDFAHHPTEIIATLDAARQKYPSKEIVAIFQPHTFTRTIALLDEFAHALSQADSVYLAQIYGSAREVDNGEVKVEDLAAKIVKHSDLVTVENVSPLLNHDNAVYVFMGAGDIQLYERSFEELLANLTKNTQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ULAF_SHIDS
Sequence: MQKLKQQVFEANMDLPRYGLVTFTWGNVSAIDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVEGEYRPSSDTATHLELYRRYPSLGGIVHTHSTHATAWAQAGLAIPALGTTHADYFFGDIPCTRGLSEEEVQGEYELNTGKVIIETLGNAEPLHTPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMAWIARSINPQLNHIDSFLMNEHFMRKHGPNAYYGQK
What is the function of this protein?
Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 4-epimerase UlaF, L-ascorbate utilization protein F, Phosphoribulose isomerase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: GYRB_METH1
Sequence: MDKIEEIHKYNADNIQILEGLEAVRKRPGMYIGSIGFKGLHHLLWEIVDNSVDEAMAGFATEIKIKLYPNNVIEVEDNGRGMPTGIHSGTKKSAVETILTVLHAGGKFDGSNYKVSGGLHGVGASVVNALSSEFEVWVKRDGKLHYQQFRNGGIPVKPLEVIGNVSEVETGTTIKFHPDYTIMEKENFDFDTIIDHSKQIAYLNKGLKITVENVEKNIIKVFCFEGGLIDYVKELNKGKKLIVPEVIYAEGVFNDKNFTNGQDVIVEVAMQYNEAYTNSIVSYANNIQTIDGGTHEQGFYDALVRIYNNYAETNKLFKTSSEKITREDVKEGLVAIISIKHTDPIFEGQTKGKLENKDARIATNKILSDSLERYLNENPEIARAIIEKCLLSQHTRLLEIKAREASRKGNGLDLGNLPGKLADCSSKNAEIRELFIVEGNSAGGSAKMGRDRSIQAILPLRGKVINAEKNSFASVLSNKEIATMIHALGTGINTEFDINKLKYHKIIIMTDADVDGAHITTLLLTFFYRYMKPLIEYGFVYLAQPPLYKITSGKNVEYAYNDLQKEQIMAKLEDKRNVAIQRYKGLGEMDPEQLWETTMDPETRKMLQVQIDDAAICDTVFATLMGEEIEPRHDFIQENAKYANNIDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_MYXXD
Sequence: MRSTYKTIGLWVILIVLFVAFYNFFSQGNDQVQEPSFTQLLTKVEEKKVQEVAVKGNTYSGKFTDTSEKFRTTGPAPDAAMLNQLRSNGVDVKYEREEQNSLWLTILGQWMPVVFLFLFFIFFMRQLQGGSGKAMTFGKSKAKLLSESHNKVTFADVAGADECKEELEEIVAFLKDPKKFTKLGGRIPKGVLMMGSPGTGKTLLARAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQGKKNAPCIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFESNDGVILIAATNRPDVLDPALQRPGRFDRRIVVPRPDVKGRLGVLKVHTRRVPLAPEVDLEVIARGTPGMTGADLENLVNESALMAARQNKERVDLSDFEAAKDKVFMGPERRSMIMTEKEKKNTAVHEAGHALLAKLLPGCDPLHKVTIIPRGQALGVTWSLPTEDKVNGYKKQMLDQISMAMGGRIAEELMFNEMSSGAANDIERATETARAMVCRWGMSEKMGPLAFGKSDGEVFLGRDFNSSKDYSEDTARQIDAEVRNIVVGCYERGKNLLTENIEALRRVSDALVEYETLDAEDVNILLQGGQLTRERPPPRVNAPPKATEKKDKRKILDALEGLPAMEPKKA
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: TATA_XANOM
Sequence: MGGFSIWHWLIVLVIVLLVFGTKRLTSGAKDLGSAVKEFKKGMHDDDKPAGKLGDDSRTAEQAREAQAERDRDAR
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RLMG_SALNS
Sequence: MSHVDDGFRSLTLKRFPQTDDVNPLLAWEAADEYLLQQLDETEIRGPVLILNDTFGALSCALAEHSPYSIGDSYLSELGTRENLRHNGIAESSVTFLDSTADYPQAPGVVLIKVPKTLALLEQQLRALRKVVTAQTRIIAGAKARDIHTSTLELFEKVLGPTTTTLAWKKARLINCTFSHPQLPDAPQTLSWKLEDTGWTIHNHANVFSRTGLDIGARFFMQHLPENLDGEIVDLGCGNGVIGLSLLAKNPQAKVVFVDESPMAVDSSRLNVETNLPEAFERCEFMINNALSGVEPFRFNAVFCNPPFHQKHALTDNIAWEMFHHARRCLKINGELYIVANRHLDYFHKLKKIFGNCATIATNNKFVILKAVKQGRRR
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRET1_DROGR
Sequence: MSGRDNRAAGAGGGSGGGGGGGGGGGNHHHHHQPLSNAMGKLKEKLTRAGEELGYHRVESNLSASNTATSLDTILPEDPFPFPQAAPQRHPQQQFPFLQQQPQQQQQPQQQQQPQQQQQLQQHHTQHTQYQQQQQQQQPLRLLHDIDDEQPLSFRPLLEDDDIHEPPQEIQQQQLQQQRGNLRASGSLELTPLPPPPTSLEPHRDRQQRSVVNEELQRSKQSLKGSRVSFERAPQQSNSNNNSKNNSKTTVAADASDDDSFEDRRVGYQQQKATSVDHKGILKDLRHILASDNRRQFQAKKHVSLDIKGTPFLQDLLKDSSSEEEFHKTRREFQGRKHQSLDPRVTFKLDKVLHGSSTDSDEEGEDAEHKRLIHRPKDITKPVIIDLKDLESESDEDFLSSRQNFQQQRSISTDSRKSRRLYEMDEMGNKRGENIRHAVPFVRQITEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGFSSAYTSPALVSMTDRNLTSFDVSTEDASWVGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIISWLLIACAVNVPMVLSGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFIAGTYMDWSMLAFLGGALPVPFLILMFLIPETPRWYVSRGREERARKALVWLRGVEADVEPELKGLMRSQADADRQATHNTMLELLKRSNLKPLSISLGLMFFQQLSGINAVIFYTVQIFKDAGSTLDGNVCTIIVGTVNFIATFIGILLIDRAGRKILLYVSNIAMILTLFVLGGFFYCKANGMDVSNVGLLPLCCFVVYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWTCTFVVTKSFLDMIKLIGAHGAFWLFGVICCIGMFFVIFCVPETQGKTLEDIERKMMGRVRRMSSVANIKPLSFNM
What is the function of this protein?
Low-capacity facilitative transporter for trehalose.  Does not transport maltose, sucrose or lactose.  Mediates the bidirectional transfer of trehalose.  Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (By similarity).
What are the official names of this protein?
Facilitated trehalose transporter Tret1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y567_KLEP3
Sequence: MAQVPAGKNRSGQLSKQTGDAWENQARRWLEGQGLRFIAANARERGGEIDLIMRDGAVTVFVEVRYRRSARYGDAAASVTPQKQQRLLKAARLWLCRQNGSFETVDCRFDVVAFTGNDIQWLKNAFGE
What are the official names of this protein?
UPF0102 protein KPK_0567.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: HLDD_BURO0
Sequence: MTLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFRNLVDCEIDDYLDKTEFVERFARGDFGKVRAVFHEGACSDTMETDGRYMMDNNFRYSRAVLDTCLAQGTQFLYASSAAIYGGSTRFVEERDVEAPLNVYGYSKFLFDQVIRRVLPSAKSQIAGFRYFNVYGPRETHKGRMASVAFHNFNQFRAEGKVKLFGEYNGYAPGEQTRDFVSVEDVTKVNLFFFDHPEKSGIFNLGTGRAQPFNDIASTVVNTLRALDNQAPLTLAQQVEQGLIEYVPFPDALRGKYQCFTQADQTKLRAAGYDAPFLTVQEGVDRYVRWLSGQV
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: RL24_ENTFA
Sequence: MFVKKGDKVKVITGKDKNKEGVVLAAFPKQDKVIVEGVNVVKKHQKPNQAAPQGGILEVEAPIHVSNVMVIDPSNGEATKVAFKEVDGKKVRVSKKTGEVLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.