PharMolix/UniProtQA huggingface dataset:
Protein: MURE_TREPA
Sequence: MLYRKPITVCLASCSVQETHGSACDVSSIAYDSRAVREGSVFFALRGTHAHGAQYIHAAIDAGACAIVHDCPLDTYVVGVYYARVPDARCALSSAAAAFYDFPTRALTVIGVTGTEGKSSTVSFIAQLLRLCGKRVGFISTVEYSLGDDILPNAEHQTTPESLTVQRLLAEMREHSCEFAVIEASSHGLSTRTARLQDVAFDVAVCMNVRHEHLEFHGSFEQYRFDKANVFRALDAHDHIKDGRRVPSFGVLWAEDASAVYFREATHKPCFFFKRGTGAEQRTAACLERMPCTLLWVQTLPQISQALRLRFVLSTVQEPAQPAQDGAHDVSVPLEGAFNACNIAASFLVLHGLLGTSLAAFAQHVQYVQPIQGRMQRVDMGQDFEVLIDYAHTPSSFEEILPPLAARVRARKRRMLVLFGSAGERDTQKRAMQGAIASRYAHVIVLTDEDPRGEDPMGILCMIAAGCEHKKLGKTLFLIPDRVAALRHIFSLARAQDLVLLLGKGHEHSIIYAHTVQPYDEERTARELLRASLSSDTLLS
What is the function of this protein?
Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramyl-tripeptide synthetase, UDP-MurNAc-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_ECO7I
Sequence: MPKIKTVRGAAKRFKKTGKGGFKHKHANLRHILTKKATKRKRHLRPKAMVSKGDLGLVIACLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: DXS_ANADF
Sequence: MGRLLDSIDSPLDLKRLPVDDLPRLCEEIREEIIQTCAKNGGHLGSSLGAVELNVALHYVYSSPTDKLVWDVGHQAYAHKLLTGRRERFRTIRTEGGLAGFPERHESEHDAFGVGHASTAISAALGMLEAKRLSGAPGKVVALVGDGAMTGGVAFEGLNQAGYLGRDLVVVLNDNEMSISPNVGALSEWFSKKFASRTYNRWRRAVKDFLSHVPKGPEAIDMIRHGINATKALVTPGILFEGLGFHYVGPVDGHDVRSLVETLQKLVIFDGPVLLHAITTKGKGYQPAESDKATRGHGLSFFDVATGKPVKKAAAKAYTDLFAEALCEEMERDPRVVAITAAMLEGTGLIKAKQRFPERTYDVGIAEQHAVTFAAGLACEGVRPVVAIYSTFLQRAYDEIIHDVALQRLPVTFALDRGGLVGADGKTHQGAFDVAYLRCVPNLVVMAPSDENELRHMLHTALHHDGPAAFRFPRGAGEGVALEAPQVLPIGKGRLARAVPGKPDVCVVALGTTLHAALAAAEALAKDGVAASVVDARFAKPLDEELIAGEAERARCVVTIEEGCLPGGFGAACLELFERRGLVAEGLRVKRLGLPDEFVTHGDQGRQRAQLGLDADGIARACRAIVGERAKRGAA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: SYS_HALLT
Sequence: MLSRQFVRENPEVVREALDNKGVDVDLDRILDVDEEWRELKSRGDDLRHERNEVSSTIGELKQAGEEEAAQEAIERSQEVKSELQEIEERADELEAELEESLLELPQIPHESVPVGADESENVERRREGFDDLREVPDNVEPHYDLGEELEILDFERGAKVAGGGFYVAKGDGARLEHALIQFMLDVHREQDYRDVFPPIAVNSTSMRGTGQLPKFTEDAYRIEGTNEDAYDDDDLWLLPTAEVPVTNLHRDEILLGEDLPLKYQAYTPNFRQEAGEHGTETRGIVRVHQFNKVEMVNFVRPEESHERFEGLVDEAEEVLRRLELPYRILEMCTGDLGFTQAKKYDLEVWAPADDMDEGPAEGGRWLEVSSVSNFEEFQARRAGIRYREEHHESAEFLHTLNGSGLAVPRIVVAILEYYQNDDGTVTVPEALRPYMGGTEVIEGHDAVGETKLGGE
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGLR_PENDI
Sequence: MRTSFVTMLALGAAAVSAAPAAPVTDLVERGSSCTFTTAEAAKAGKGSCSTIVLDNIKVPAGETLDLTKLKSGTQVVFKGETSFGYKEWTGPLVSFSGSNIHVSGAAGHVINGGGPSWWDGKGTNGGKKKPKFFYAHHLDDSTISGLNVKNTPVQGFSILADRLTLDHITIDNSEGDAKGGHNTDAFDVGSSTFITISNANIKNQDDCLAINSGSNIKFVGGTCSGGHGISIGSVGLRDNNIVKDVTISDSTVINSDNGVRVKTIYQATGAVSGVTFSNIKLSNIAKYGIVIEQDYENGSPTGKPTNGVPISELTIENVTGTLKSSATEVYILCGNGSCKNWKWAGNSLSGGKKSGKCGNVPAGASC
What are the official names of this protein?
Polygalacturonase, PG, Pectinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HBA2_SAAHA
Sequence: VGPHLDDYGGEALHRNFEVYPQTKTYFPHFDASAGSNQLK
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-2, Alpha-2-globin, Hemoglobin alpha-2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SCRG1_HUMAN
Sequence: MKLMVLVFTIGLTLLLGVQAMPANRLSCYRKILKDHNCHNLPEGVADLTQIDVNVQDHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNQ
What are the official names of this protein?
Scrapie-responsive protein 1, Scrapie-responsive gene 1 protein, ScRG-1.
What is the protein family that this protein belongs to?
Belongs to the SCRG1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MED4_DEBHA
Sequence: MIPHKKNDSSFLSVPVSRVGSTQRLNQLASHGVATGSPNAYSSIPSTPSAYVSSSLNPTKGISAGPESSNQIITKEDRDAFGKLSIVEKVNEFEQNLTNLSFKVSSFKEDELASLIGKLIELNDIICSEIGELKKHRDLGILIKGLKDDQAHLDNTSKIILKELITYRNELKKLPRLPSNKNKASVFPSPNDSKVDVNEVLKYASKLSKFTKAPPTVSNLPFQIHPNNYVWPAEDALRRGMLAMSSIKVDDIINAELGEDTLEVKEEAIKKVEDNKVESITNSPPAERRGSFGERTGESRKQESQGALDLDLFDPDEEDFSD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 4, Mediator complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYC6_CHLRE
Sequence: MLQLANRSVRAKAARASQSARSVSCAAAKRGADVAPLTSALAVTASILLTTGAASASAADLALGAQVFNGNCAACHMGGRNSVMPEKTLDKAALEQYLDGGFKVESIIYQVENGKGAMPAWADRLSEEEIQAVAEYVFKQATDAAWKY
What is the function of this protein?
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
What are the official names of this protein?
Cytochrome c6, chloroplastic, Cytochrome c-552, Cytochrome c-553, Cytochrome c553, Soluble cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PetJ subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: DNAA_EHRRG
Sequence: MNNDNTEVLENYPQDGLQSNSHIIWKGIQSRLHKFYGNAIYDSWLSVLLYVSTESGKVLLSAPTRFIKEWILVHYLDQILKYWQDEDQSICSVDICVVSNQDPNLLVDIKDRVDRGIKGNCDNVSSPLDPRFTFDNFVVGKPNELAFAAARRVAESNSPISGSNPLFLYGGVGLGKTHLMHAIAWYIIKSCSKRKIAYLSAEKFMYQYVTALRSKDIMLFKEQFRSVDILMVDDVQFISGKDSTQEEFFHTFNALIDQNKQLVISADRSPSDLDGVEERIKSRLGWGLVADINETTFELRLGILQLKVEKMGINIPNKVLEFLAKNIKSNIRELEGALNKVVAHSSLVGCSITLDTASDILSDLLRANHKSVTLECIQKKVAEFFNIKVSDMYSTRRLRTLARPRQIAMYLSKKLTQKSLPEIGKSFGGRDHATVIHAVKQIEKLMDTDSKLRDDINLLNRMLR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_HISS2
Sequence: MYSRILATGSYIPANIRTNADLEKMVETSDEWITTRSGIKERRIAGENETVATMGFEAAKNALQLANICPNDIDLVLVATTSHSYAYPSAACQIQGMLDIDDAISFDLAAACTGFIYALSVADQFIKTGKVKKALVIGADINSRKLDETDRSTVILFGDGAGAVILESSDIEGIISTHLHASLDKSNALILPQTQQGEVQSGYIQMQGNATFKLAVRELSNVVEETLRDNHLDKADLDWLVPHQANLRIITATAEKLNMSLDQVVITLDKYGNTSAATVPVALDEAVRDGRIKRGQLLLLEAFGGGWTWGSALVRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBP1_PLAVB
Sequence: MKRGICLAALLCLFNYLGAGHGENAEEDIRNSEGKVNFFSLDSNLKKNKKSKHNRVKRRNAKISNFLSQKAYVKETDNASGKDAEGSRPSHDSSFVNLNGHVDGKSLSYSVHVKESTPHSTTRESTEKGKENEKIQGVLSSFVQSQEGGESDDLEGMYNSIVDMSEKLKENDKYNLVFDMEIDFVDLQFFNLILELIPKDSQYHTYYEETLKQQVTEYTNSLKTLMDSCISEKDQMIILEYEINYAKRKSIETETLGDKETKLSAVSQAYAKHLESYKGVLKPKLNDIKNNAFSVLKDSYCKDNCGEYVQKYNTMRKNFISSSDQYKMEAYVYIPKSINDYTVLDKILSESNELGIDIQETVNSLKLLGEEISEVSHLYVINSTLIDDAAKKLESINEEDESAEIDLQKFEDNSKALANNYCIFQYIKTLNEPIKKAYESKVIKSNELLSTIIDTLGKSATALQESTFDQEECNKIKTEAEKVKDDAEDICEKNEQIYYEIPESEDETIDDKINDLQDLIDQMKEYKDEIVNNSEFISNRYKNIYENLKETYETELNDIGKLENDTSKVNFYLMQIRKINTEKTKIDESLQTVEKFYKEILDSKEKIYELKIEFEKSVTEINRLQDGESARDLHEEQIKEILDKMAKKVHYLKELLSLKGKSSVYFTEMNELLNTASYDNMEGFSAKKEKADNDINALYNSVYREDINALIEEVEKFVTENKESTLEMLKDEEMEEKLQDAKETFAKLNFVSDDKLTDVYTKMSAEVTNAEGIKKEIAQKQFENVHKKMKEFSDAFSTKFEALQNSMQQYNQEGDAIEKHKQNRSEKEEEYFKNESVEEDLSREETEEQEYTKHKNNFSRRKGEISAEITNMREVINKIESQLNYYGVIEKYFSLIGDQNEVSTAKALKEKIVSDSLRDKIDQYETEFKEKTSAVENTVSTIQSLSKAIDSLKRLNGSINNCKKYNTDIDLLRSKIKTLREEVQKEIAETEGDKVVGENTTALLLKSLRDKMGKINEKLNDGRLNSLDTKKEDLLKFYSESKSKIHLSKDQKGPQDPLNRIDEWEDIKREVDELNVNYQVISENKVTLFKNNSVTYIEAMHSHINTVAHGITSNKNEILKSVKEVEDKLNLVEQNEDYKKVKNPENEKQLEAIRGSMSKLKEVINKHVSEMTQLESTANTLKSNAKGKENEHDLEELNKTKGQMRDIYEKLKKIAEELKEGTVNELKDANEKANKVELEFERNIIGHVLERITVEKDKAGKVVEEMNSLKTKIEKLIQETSDDSQNELVTTSITKHLENAKGYEDVIKRNEEDSIQLREKAKSLETLDEMKKLVQQVNMNLQSAIQGNAGISKELNELKGVIELLISTNYSSILEYVKKNSSESVRFSQLANGEFTKAEGEEKNASARLAEAEKLKEQIVKDLDYSDIDDKVKKIEGIKREILKMKESALTFWEESEKFKQMCSSHMENAKEGKKKIEYLKNNGDGGKANITDSQMEEVGNYVSKAEHAFHTVEAQVDKTKAFYESIVAYVTKMDNLFNESLMKEVKVKCEKKNDEAEQIFGQIKTVDGRIKARVSENERKISELKEKAKVEKKESSQLNDVSTKSLLQIDNCRQQLDSVLSNIGRVKQNALQYFDSADKSMKSVLPISELGAEKSLDKVKAAKESYEKNLETVQNEMSRINVEEGSLTDIDKKITDIENDLLKMKKQYEEGLLQKIKENADKRKSNFELVGSEINALLDPSTSIFIKLKLKEYDMTGDLKNYAVKMNEIHGEFTKSYNLIETHLSNATDYSVTFEKAQSLRELAEKEEEHLRRREEEAIKLLNDIKKVESLKLLKEMMKKVSAEYEGMKRDHTSVSQLVQDMKTIVDELKTLNDISECSSVLNNVVSIVKKVKESKHADYKRDANSMYESMVTLANYFLSDEAKISSGMEFNAEMKSNFKTDLELEIFSVISNSNELLKKIEQDSNDVIQKERESEQLAKDATDIYNVIKLKNEFNEKLEEAKNKEEVVSEKVREALKRLSQVEGIRCHFENFHRLLDNTEELENLKKMVTIYRDKKSEAPKESGLQEMENEMNTYSNSITQLEGIVVSAGESKEDIEKLERSNEEMRNISEKISTIDSKVIEMNSTIDELYKLGKNCQAHWISLISYTANMKTSKKLIMINKEKENTEKCVDYIKDNSSSTDGYVETLKGFYGSKLTFSSASEIVQNADTYSVNFAKHEKESLNAIRDIKKELYLFHQNSDISIVEGGVQNMLALYDKLNEEKREMDELYRNISETKLKQMEHSTDVFKPMIELHKGMNETNNKSLLEKEKKLKSVNDHMHSMEAEMIKNGLKYTPESVQNINNIYSVIEAEVKTLEEIDRDYGDNYQIVEEHKKQFSILIDRTNALMDDIEIFKKENNYNLMEVNTETIHRVNDYIEKITNKLVQAKTEYEQILENIKQNDDMLQNIFLKKVSIIEYFENVKKKKESILNDLYEQERLLKIGEHLDEIKRNVTETLSSYEIDQKMEMMSKNLLEKKSKMMNYTSIYELEREANEINRDAKQIKDDDTILNSVLEAAIQKRGDMDAIFSQMSADRNPNEYKSAEKYMNEANEIIRQLEVKLREIGQLVQDSESILSEMNSKKSAIEKEKTARALRTSENNRREEEERARVQEMSMNNDPTQSETTHSEGSIGEGKESDSDETGLTHDAGADEDSTSSAKGAHELEEEETTAPMEETEMNDNTLLGYDTTRSDEPDMHTENTQDGTYQDTSNSSDEADILNGKFNFNNVKYAGAFVLLCTSAVIGAIIAHKKDDQEELNNGVEDDKVFEVKKSMHPENKEEIIDDSFVDIEY
What is the function of this protein?
Involved in reticulocyte adhesion.  Specifically binds to human reticulocyte cells.
What are the official names of this protein?
Reticulocyte-binding protein 1.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: Y931_HAEIN
Sequence: MKSHRTLYKSAVFLYLIFKGKRMLHLTLEDELFLGTPKQVGTHSTVFEHFAVMFEDDGETGYFYALDMRQNAQPIVDMLHVYNVDSTSNHHEARKLEICWDESGYVALLLINGYPHAVFDFARLVGYNSNKYPQPDLMSMWTREEITNKQAEQWLGVKTIR
What are the official names of this protein?
Uncharacterized protein HI_0931.
Protein: HSL52_DICDI
Sequence: MTLFSSISSISNPMTSSKSSIASFGSGTSMGSNSIACGGGCGGSDGILGLGLGLSLGLGLGLNLTGGSRSRGGCGGSNGSMGGGNGSCCGI
What are the official names of this protein?
HssA/B-like protein 52.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: RUVC_YERPY
Sequence: MAIVLGIDPGSRVTGYGVIRQQGRQLTYLGSGCIRTVVDDMPTRLKLIYAGVTEIITQFQPDFFAIEQVFMAKNPDSALKLGQARGAAIVAAVNLNLPVSEYAARQVKQTVVGTGAAEKSQVQHMVRSLLKLPANPQADAADALAIAITHCHLSQNTLRLGNDQMTLSRGRIR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: CALX1_ARATH
Sequence: MRQRQLFSVFLLLLAFVSFQKLCYCDDQTVLYESFDEPFDGRWIVSKNSDYEGVWKHAKSEGHEDYGLLVSEKARKYGIVKELDEPLNLKEGTVVLQYEVRFQEGLECGGAYLKYLRPQEAGWTPQGFDSESPYSIMFGPDKCGGTNKVHFILKHKNPKSGEYVEHHLKFPPSVPYDKLSHVYTAILKPDNEVRILVDGEEKKKANLLSGEDFEPALIPAKTIPDPEDKKPEDWDERAKIPDPNAVKPEDWDEDAPMEIEDEEAEKPEGWLDDEPEEVDDPEATKPEDWDDEEDGMWEAPKIDNPKCEAAPGCGEWKRPMKRNPAYKGKWSSPLIDNPAYKGIWKPRDIPNPDYFELDRPDYEPIAAIGIEIWTMQDGILFDNILIAKDEKVAETYRQTTWKPKFDVEKEKQKAEEEAAGSADGLKSYQKVVFDLLNKVADLSFLSAYKSKITELIEKAEQQPNLTIGVLVAIVVVFFSLFLKLIFGGKKAAAPVEKKKPEVAESSKSGDEAEKKEETAAPRKRQPRRDN
What is the function of this protein?
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum.  It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits.  It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity).
What are the official names of this protein?
Calnexin homolog 1.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: SPRE1_HUMAN
Sequence: MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFIRGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFEDLNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQDEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDETKLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCYVPLRMCHRCGEACGCCGGKHKAAG
What is the function of this protein?
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity).  Negatively regulates hematopoiesis of bone marrow (By similarity).  Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).  Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281).  Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
What are the official names of this protein?
Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions.
Protein: CENPX_CHICK
Sequence: MEEREGGFRKETVERLLRLHFRDGRTRVNGDALLLMAELLKVFVREAAARAARQAQAEDLEKVDIEHVEKVLPQLLLDFV
What is the function of this protein?
DNA-binding component of the Fanconi anemia (FA) core complex.  Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage.  In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA.  Stabilizes FANCM.  In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (By similarity).  In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631, PubMed:22304917).  As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.  DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded.  Does not bind DNA on its own (By similarity).
What are the official names of this protein?
Centromere protein X, CENP-X.
What is the protein family that this protein belongs to?
Belongs to the CENP-X/MHF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS.
Protein: ECL1_YEAST
Sequence: MSTAFNDYCTVCDRLIPTSPQKTNINTRKIQRDNETKSSLQSNKLYCSEDCKLKDSNPLNEKLLSHLHKKSKTSHSHNLTPPLSYSKNLTASNLFEPTTSLSSSPTSSTIPFDELEKLESLLISPLLLPQDGIVNPKQESNPSRVDEYDENEHYLNLADSLRLDSSYQLHSKAHLGYENNLPRSNDLIDDHLISDQIIENNYNLWFRLSSS
What is the function of this protein?
Involved in chronological cell aging.
What are the official names of this protein?
Extender of the chronological lifespan protein 1.
What is the protein family that this protein belongs to?
Belongs to the ecl1 family.
Protein: MTRB_METMP
Sequence: MDIVKVCPELHIVMDVDSGLIAEMRKDILVVDLHPVEDEINKLAQYAKALENSLDPRNTPMKAYAGREGTYKLAGMFQGMFFGFWVTMAVLVLVTILAVKMNLSLIGL
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit B, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit B.
What is the protein family that this protein belongs to?
Belongs to the MtrB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: UTS1_PLAFE
Sequence: AAAAGDSAASDLLGDNILRSEDPPMSIDLTFHMLRNMIHMAKMEGEREQAQINRNLLDEV
What is the function of this protein?
Urotensin is found in the teleost caudal neurosecretory system.  It has a suggested role in osmoregulation and as a corticotropin-releasing factor.  The non-hormonal portion of this precursor may be a urotensin binding protein, urophysin.
What are the official names of this protein?
UI.
What is the protein family that this protein belongs to?
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
What are the subcellular locations of this protein?
Secreted.
Protein: PG136_VACCW
Sequence: MMPIKSIVTLDQLEDSEYLFRIVSTVLPHLCLDYKVCDQLKTTFVHPFDILLNNSLGSVTKQDELQAAISKLGINYLIDTTSRELKLFNVTLNAGNIDIINTPINISSETNPIINTHSFYDLPPFTQHLLNIRLTDTEYRARFIGGYIKPDGSDSMDVLAEKKYPDLNFDNTYLFNILYKDVINAPIKEFKAKIVNGVLSRQDFDNLIGVRQYITIQDRPRFDDAYNIADAARHYGVNLNTLPLPNVDLTTMPTYKHLIMFEQYFIYTYDRVDIYYNGNKMLFDDEIINFTISMRYQSLIPRLVDFFPDIPVNNNIVLHTRDPQNAAVNVTVALPNVQFVDINRNNKFFINFFNLLAKEQRSTAIKVTKSMFWDGMDYEEYKSKNLQDMMFINSTCYVFGLYNHNNTTYCSILSDIISAEKTPIRVCLLPRVVGGKTVTNLISETLKSISSMTIREFPRKDKSIMHIGLSETGFMRFFQLLRLMADKPHETAIKEVVMAYVGIKLGDKGSPYYIRKESYQDFIYLLFASMGFKVTTRRSIMGSNNISIISIRPRVTKQYIVATLMKTSCSKNEAEKLITSAFDLLNFMVSVSDFRDYQSYRQYRNYCPRYFYAGSPEGEETIICDSEPISILDRIDTRGIFSAYTINEMMDTDIFSPENKAFKNNLSRFIESGDITGEDIFCAMPYNILDRIITNAGTCTVSIGDMLDNITTQSDCNMTNEITDMINASLKNTISKDNNMLVSQALNSVANRSKQKIGDLRQSSCKMALLFKNLATSIYTIERIFNAKVGDDVKASMLEKYKVFTDISMSLYKDLIAMENLKAMLYIIRRSGCRIDDAQITTDDLVKSYSLIRPKILSMINYYNEMSRGYFEHMKKNLNMTDGDSVSFDDE
What is the function of this protein?
Core protein 4a is the most abundant virion protein.  Major component of the virion core that undergoes proteolytic processing during the immature virion (IV) to mature virion (MV) transition.
What are the official names of this protein?
Major core protein OPG136 precursor, p4a, Virion core protein 4a precursor.
What is the protein family that this protein belongs to?
Belongs to the orthopxvirus protein OPG136 family.
Protein: AIM34_YEAS8
Sequence: MSISLLGRIVSQQFSGIRAAGPGRSLYLPFTLLLKQPGAYKVTLHRYVHSTQTKSHLSFLMNNNDITPFQKFTVKVLKEQCKSRGLKLSGRKSDLLQRLITHDSCSNKKSSVKINEPKKKRILINDPIKITKKLVSDKTFRTIEKNISSLQNTPVIETPCDVHSHLQPRDRIFLLGFFMLSCLWWNLEPQESKPTIDH
What are the official names of this protein?
Altered inheritance of mitochondria protein 34, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM34 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: RNH3_STAA1
Sequence: MANIVFKLSDKDITTLMSRITFDTENLPQGMKARAKYQNTTVNIYQSGKVMFQGNHAEAVSKELLPQHSQLNTNKTKKKNMANSSLEQTLMYDQFNCIGSDEAGSGDYFGPLTVCAAFVTKEHVPILKTLGVDDSKKLTDTKIVELAEQLVAFIPHSLLTLHNDKYNIQQAKGWTQVKMKAVLHNEAIKNVLEKIDSSQLDYIVIDQFAKREVYSHYALSDIPLPKKTKFETKGESKSLAIAVASIISRYAFITYMDQISKYINMTIPKGAGAKVDVIAAKIIKKYGLSRLDTISKKHFKNREKAQKILKPL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCL2_ORYSJ
Sequence: MAPPPPPTRCLPVLLLLLLVVAPLLAHGRRPFISDGGNANANANASVLRLPSAAAAAGEDMGCEMSYGFLPCTTTAWGNLFLVLAYGFLMFKSATYLSSGSEMLLQILGPGIVGGLFLPILGALPDALLILVSGLSGTKEVAQSQVLIGMGLLAGSTVMLLTLLWGSCVVVGKCDLSENSTAIDSRDTKGFSLLGSGVSTDKQTSYAARIMAISILPFIIVQIPKIFKLHSGHQITVLIGLIVAALLLLSYCLYQVFQPWIQRRRLEYTRLKHVMSGLLRHAQKHSIGRLLDDEGRPNVSVIEKLFHRIDQDNDGKLERGELQAFIVGINFEDIDWNSNLAADQVMADFDTSRNHFIEKGEFVNGMLRWLDEAKRTVTSGAYSKKFLNDFHARTRDEQTGLLDKDEEEGEADGNPTWTCIKAILLLLLGTAMAAASADPLVDAVHNFSNATHIPSFFISFIVMPLATNSSEAVSAIIFASRKKKRTLSLTFSEVYGGVTMNNTLCLAVFLALVYVRGLTWDFSSEVLIILLVCIIMGLFTSFRTDFPLWTCFVAFLLYPLSLIMVYILDYKFGWS
What is the function of this protein?
May function as a sodium/calcium exchanger (NCX) and participate in the maintenance of calcium homeostasis.  May play a role abiotic stress responses.
What are the official names of this protein?
Sodium/calcium exchanger NCL2, Na(+)/Ca(2+)-exchange protein NCL2, OsEFCAX2, Protein NCX-like 2, OsNCL2.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.