Protein: CND1_CAEEL
Sequence: MPRKQRVVTTPSPPTSDEDEDMDFGSTSQQQQQQPTRNNDGLSGFKSITEIIAEADNNIPSEQIDKDIDSFSSYSDISDWRGIPKFFPSLSSLSRRASTYENWENRFKVVDYLVSCSGALKDSVSDYVADYFEKNESGEDHSVDVELVHAVSMFVILTQRLTVQLQLYVSKSIASANQQAKRGTGRGGRQVDLDDDIVKWKDIQRHRMINCLLELLELRVDTVAGTKKKAIQYVFAPDVMEKDFLLRFLDTVVQLLEDPENMARSSQQWISHYFRILKVLSADYGMTKDVANCLFTALSHSYLEAANTFPFIEPLVTLMKENGEGSGRIYQPLRNVLQLVICRVGNLYAGERAEKPPPKAFCMMVQSLAINVHDLMLQDITHVYRLLQNQHVNVRMSTLHALADMFSSSYLSQSLCDTFASRRLKREGIFKRLLAHTNDEATNVRSKAVSLLRNIMENRRIPEEFESCGLLSIVGSRLNDKSVQVRKSAIQFLTTFLDNNRHGHDFNREMHQLKLNAKCSELRNAEEPQSKAIQGAENAFRQNLFTLTAGVRVEVYDIFRRRYRVEPERSITDILTGLFSPGSGNRLVRYYVAQENFPFRDRIPSLRERRSDDMEDDDDDTVSLEDDDMTSLVSEVVKWVVAQAEEDYVTFKVQLTQMDDDQLLENEQEARDRNNQIMQLRAQVQQLINKMSIEQELSRCVTIALRCVLNGETAEIKEGIRFLTRCKLFEITGADDAIRSMCSLVWRPSADILNELIEAAEDMFISRLDGNEKASERDSSTVENLMKAMNGVTEKDRPSVEEVIYLLAATELVHVDSDKNKVPRKRRPIEANVINKLWMIALDMSHGINSRKIDALRILYPISRSERGIAEARSRLRVVQKKLMDPELAVDALRIISILGTPTKLENEQDAYSRPLFKIHQDDSLWKSIEKLFFYEIMKADDNPDRDWFGVIRLTITTILSLSMDVNVMLPKLASHFVYRTKRISDFFLFYCDQVDDATDDTRKKMAQRRREYWALTYCRVMEKLMAFIGEVAVQLNAYIQVTIPKLHTRYVSKMVDAEKNDANIREEPVRFLSDLEKSVAQRKTIFTVPQDTTPGATSNDLHHLVSVMCDKRLFVPNKLMGRLLPIVVYGMRCKIMPTRIRHAATVAYGKMMPLSAEISAFAAPSFFSAMTKSSSILLRCNLVAACCDFAFAQPTLFELFAQSLFRMSQDESPLARESTILVLSHLMSNDMIQTRGVLSEAARCICDPTRAVRDVAQSFFKELNSRTDTIIQLLPEFLYHLSNGNERMSFKSYKTVFEFLIQLLKDKPKASADSMIDRVCIKFSNTDMNDSETPKYLLVALAKFVQNDGGLHRLQDNWRHWSKFMCHPSVAKEYRMMVEHMHSTSKNDEFKSQCVELIDNINKIESEGLRKEDVAIGSSITKNKGRAKKNPTTMSGSSRTTSRAANSRRRAPPPAQSDEDDSDSDDAPAAPRSAARRKAKKSAVADDDSDSDEFMLDD
What is the function of this protein?
Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners (PubMed:19119011, PubMed:19781752, PubMed:3779843, PubMed:18198337).  Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes (PubMed:19781752, PubMed:19119011).  The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity).  The condensin I complex function is required for proper chromosome segregation in mitosis and meiosis (PubMed:19119011).  As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, possibly by influencing higher-order chromosome structure (PubMed:18198337, PubMed:19781752).  Plays a role in robust cytokinesis upon presence of chromatin obstructions (PubMed:23684975).  Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization (PubMed:3779843, PubMed:19119011, PubMed:15557118).
What are the official names of this protein?
Condensin complex subunit 1, Non-SMC condensin I complex subunit dpy-28.
What is the protein family that this protein belongs to?
Belongs to the CND1 (condensin subunit 1) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=During mitosis, localizes to condensed chromosomes in both sexes. In interphase cells, diffusely distributed in nuclei of hermaphrodite embryos prior to the onset of dosage compensation. Localizes to the X chromosome after the 40-cell stage when dosage compensation is initiated in hermaphrodite (XX) but not in male (X0) embryos, where it remains diffusely nuclear.