PharMolix/UniProtQA huggingface dataset:
Protein: M2_I83A1
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRLFKHGLKRGPSTEGVPESMREEYREEQQNAVDADDGHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: AHP4_ARATH
Sequence: MTNIGKCMQGYLDEQFMELEELQDDANPNFVEEVSALYFKDSARLINNIDQALERGSFDFNRLDSYMHQFKGSSTSIGASKVKAECTTFREYCRAGNAEGCLRTFQQLKKEHSTLRKKLEHYFQASQ
What is the function of this protein?
Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs).  Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay.
What are the official names of this protein?
Histidine-containing phosphotransfer protein 4.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: RS2_PROM5
Sequence: MAVVSLSEMMEAGAHFGHQTRRWNPKMSKYIYCARNGVHIIDLVKTALCMNNAYKWTRNAAKSGKRFLFVGTKKQASDVVAQEAVRCGAAYVNQRWLGGMLTNWSTMKARIERLKDLERMESSGAIAMRPKKEAAVLRRELERLQKYLGGLKGMRRLPDVVVLVDQRRESNAVLEARKLDISLVSMLDTNCDPDLCEVPIPCNDDAVRSVQLILGRLADAINEGRKGSNDQRKV
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RL31_MYCSJ
Sequence: MKTGIHPDYVETTVQCGCGNTFTTRSTKKTGNIVVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRGANKAANTDSADK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: G3PP_PYRFU
Sequence: MRRIKVIFFDLDDTLVDTSKLAEVARKNAIENMIRHGMPVDFDTAYNELLELIKEYGSNFPYHFDYLLRRLDLEYNPKWVAAGVIAYHNTKFTYLREVPGARKTLLRLKKEGYMTGIITDGNPIKQWEKILRLELDDFFEHVMISDFEGVKKPHPKIFKKALKAFNVKPEEAIMVGDRLYSDIYGAKNVGMKTVWFKYGKYAELDLEYKEYADYVITELPQLLEVLERENGSDKEVHSSG
What is the function of this protein?
Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.
What are the official names of this protein?
Glyceraldehyde 3-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
Protein: STPAP_HUMAN
Sequence: MAAVDSDVESLPRGGFRCCLCHVTTANRPSLDAHLGGRKHRHLVELRAARKAQGLRSVFVSGFPRDVDSAQLSEYFLAFGPVASVVMDKDKGVFAIVEMGDVGAREAVLSQSQHSLGGHRLRVRPREQKEFQSPASKSPKGAAPDSHQLAKALAEAADVGAQMIKLVGLRELSEAERQLRSLVVALMQEVFTEFFPGCVVHPFGSSINSFDVHGCDLDLFLDLGDLEEPQPVPKAPESPSLDSALASPLDPQALACTPASPPDSQPPASPQDSEALDFETPSSSLAPQTPDSALASETLASPQSLPPASPLLEDREEGDLGKASELAETPKEEKAEGAAMLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALHNSRFLSLCSELDGRVRPLVYTLRCWAQGRGLSGSGPLLSNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEGEQVEVDGWDCSFPRDASRLEPSINVEPLSSLLAQFFSCVSCWDLRGSLLSLREGQALPVAGGLPSNLWEGLRLGPLNLQDPFDLSHNVAANVTSRVAGRLQNCCRAAANYCRSLQYQRRSSRGRDWGLLPLLQPSSPSSLLSATPIPLPLAPFTQLTAALVQVFREALGCHIEQATKRTRSEGGGTGESSQGGTSKRLKVDGQKNCCEEGKEEQQGCAGDGGEDRVEEMVIEVGEMVQDWAMQSPGQPGDLPLTTGKHGAPGEEGQPSHAALAERGPKGHEAAQEWSQGEAGKGASLPSSASWRCALWHRVWQGRRRARRRLQQQTKEGAGGGAGTRAGWLATEAQVTQELKGLSGGEERPETEPLLSFVASVSPADRMLTVTPLQDPQGLFPDLHHFLQVFLPQAIRHLK
What is the function of this protein?
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410).  Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197).  In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410).  In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955).  However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197).  Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955).  Not involved in replication-dependent histone mRNA degradation.
What are the official names of this protein?
Speckle targeted PIP5K1A-regulated poly(A) polymerase, Star-PAP, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus speckle.
Protein: DEFB1_PONPY
Sequence: MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK
What is the function of this protein?
Has bactericidal activity.  May act as a ligand for C-C chemokine receptor CCR6.  Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner.  Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
What are the official names of this protein?
Beta-defensin 1, BD-1, Defensin, beta 1.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
Protein: ATPL_METJA
Sequence: MVDPLILGAVGAGLAVGIAGLGSGIGAGITGASGAGVVAEDPNKFGTAIVFQALPQTQGLYGFLVAILILFVFKTVSPWAMFAAGLAAGLAGLSAIGQGIAASAGLGAVAEDNSIFGKAMVFSVLPETQAIYGLLIAILLLVGVFKGNAGAETVAALGAGFAVGFAGLSGIGQGITAAGAIGATARDPDAMGKGLVLAVMPETFAIFGLLIAILIMLMIK
What are the official names of this protein?
Probable ATPase proteolipid chain.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase proteolipid subunit family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUB_ARTS2
Sequence: MLSGLVIVDKPQGWTSHDVVGRMRRLAGTRKVGHAGTLDPMATGVLVLGINKATRLLTYIVGTSKTYTATIRLGESTVTDDAEGEVVSSHSAAAVTEGAIRAAVAALTGEIQQVPSSVSAIKVNGERAYARVRSGEDVKLAARPVTIHRFDVHAVRPERAGAVLDVDVTVECSSGTYIRALARDLGEALGTGGHLTALRRTQVGPYTLDQARTLEQLAEELEVLEMSQAARALMPNRELSEDEATEISFGRRIAAGAGAGTPEAATADNPAAAFAPDGSLVALLADAGGYAKPVLVFAPSNEQPGK
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RIBL_HALLT
Sequence: MTRVVAQGTFDLLHPGHVHYLEDAATYGDELHAIVARRTNVTHKPAPILCAEQRRDMVAALTAVDEAHLGHPEDVFVPIQRLDPDVIVLGFDQHHDEADIAAALAERGIDCRVERASGRDPRYEDELLSSGDIVDRILKQRGSDCDGAREGQR
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.
Protein: LPXH_SALPC
Sequence: MATLFIADLHLQTEEPAIVAGFLRFLAVEARQADALYILGDLFEAWIGDDDPNPLHREMAVAIKSLVDSGVPCFFIHGNRDFLIGKRFARESGMILLPQEKVLDLYGRNVLIMHGDTLCTDDAGYQAFRAKVHNPWVQRLFLTLPLFIRRRIAARMRAGSKAANSSKSLDIMDVNAQTVVAEMEKHRVQWLVHGHTHRPAVHELSVNDQPAFRVVLGAWHHEGSMVKVTPDNVELIAFPL
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL18_CALS8
Sequence: MGLYKKVNRNEKRLIRHKRIRKKVFGTAERPRLCVYKSLKYIYAQIIDDEKGHTLVAASSLEPEIKSRLTSTKSIEAAQYIGRVIAERAKEKGITKVVFDRGGYPYHGRVKALADAAREAGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: SSH1_HUMAN
Sequence: MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESAWADRVRYMVVVYSSGRQDTEENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWSALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKELKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREALLEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLDQNLLNSENLNNNSKRSCPNGMEDDAIFGILNKVKPSYKSCADCMYPTASGAPEASRERCEDPNAPAICTQPAFLPHITSSPVAHLASRSRVPEKPASGPTEPPPFLPPAGSRRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNSHCDKNPPSTEVVIKEESSPKKDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSVPADPAPPSRDGPASRLEASIPEESQDPAALHELGPLVMPSQAGSDEKSEAAPASLEGGSLKSPPPFFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIETRLRLAGLTVSSPLKRSHSLAKLGSLTFSTEDLSSEADPSTVADSQDTTLSESSFLHEPQGTPRDPAATSKPSGKPAPENLKSPSWMSKS
What is the function of this protein?
Protein phosphatase which regulates actin filament dynamics.  Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.  Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
What are the official names of this protein?
Protein phosphatase Slingshot homolog 1, SSH-like protein 1, SSH-1L, hSSH-1L.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
Protein: RS3A_CULQU
Sequence: MAVGKNKGTSKGGKKGSKKKVVDPFTRKDWYDVKAPNMFSCRQVGKTLVNRTQGTRIASDGLKGRVFEVSLADLQNDTDAERSFRKFKLIAEDVHGRNVLCNFHGMDLTTDKLRSMVKKWQTLIECSVDVKTTDNYLLRVFCIGFTIKDQVSQRKTCYAQHSQIKAIRKNMTQIITNNVTSSDLKEVVNKLLPDSIAKDIEKACQGVYPLHDVYIRKVKVLKKPRFDLANLLELHGDGGGKGAEVSTGAAEGGVVVDRPEGYEPPVQESV
What are the official names of this protein?
40S ribosomal protein S3a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_PARXL
Sequence: MNAPEILNGATAAAPAGTGEATPVHARARSPLTRREQKEAYENNKLFKRLARQVGEAIVDFNMIEDGDKVMVCLSGGKDSYAMLEILMRLRERAPINFDIVAVNLDQKQPGFPEHVLPEYLKQLDIPFHIENQDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVAGELGATKIALGHHRDDILQTLLLNMFYGGKLKGMPPKLQSDDGKNIVIRPLAYVKETDLEKYAELREFPIIPCNLCGSQPNLKRAEMKALVRDWEKRFPGRIENMFNALANVVPSHLMDHKLFPFAGLRATGEADPQGDIAFDEEPCSTDSGNSTTLDGAKSIAIVQFDDL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_WOLWR
Sequence: MEIGISKYRNIGIMAHIDAGKTTTTERILFYTGKQNRIGEVHDGAASMDWMEQEKERGITITSAATTCFWNDHRVNIIDTPGHVDFTIEVERSLRVLDGAVAVFDGVAGVEPQSETVWRQADKYSVPRICFVNKMDRIGANFYRCVDMIKTKLGAAPLVIHLPIGSEKDFKGIIDLISMKAIIWQEETLGAKFSYEDIPSDLLDKAQEYRNLLLDAAAEMDDEAMNTYFESNDLPVDLLKKCVRNGTIKGKFVPVLCGSAFKNKGVQPLLDGVVDFLPSPIDVDVIVGIDPKDSEKKIEVKPSEKEKFVALAFKVMTDKFVGSLTFIRIYSGKLKSKSTVSNALKNETEGIGRMLLMHANNREDITEARAGDIVALVGLKKTTTGDTLCSVDFPILLERMEFPEPVIEIAVEPKTTSDQEKLGIALNRLVAEDPSLRMSVNAESGQTILKGMGELHLEIIVDRMKREFNVEANVGAPQVAYRETITKSVEIDYTHKKQSGGAGQFAKVKIKFEPLEPGSGFQFESKIVGGAIPKEYIPGVENGLELIKEGGIISGFPLIDFKATLLDGAFHEVDSSPLAFELAAKGAFKEMANKAGPKMLEPIMKVEIITPEEYMGDVMGDINSRRGNVADMLDLGNNSKIITASVPLANMFGYINVLRSMSQGRAQYSMHFSCYEQVPQYVVDELKLEYN
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED17_ASPCL
Sequence: MSDQFTLPLRPLIEERDHQDLLPVEIAQISAQWGSFRDVNEETLRAKIEEEKNKEYTIDDEEGEGASVDLDTTERLDQLYKKRAEITQFAMQAHMEAMFALDFISLLLSKYTPRQAETSMSAFLKQVAPLGSLTAELVNPPPKSEAAVRDAKAVSRGWRLQSFNAAADKLLKSAARLETEVASETRYWSEVLAVKDKGWKVCRLPREGQALGVQYGFLEATPIFRDRGLAALRRSEDGGLILDKGLVPAKAKTVRVRVKNRGVVTGCSKPYRSAVQDSESIEGRILQARDTLYEEELFYELVREARIMGSQGVSTGQNLVQFSVSEDEEVLLDLVDPDVAYADDSETSLEHTVVADALAHSIRILLSYAHRQNRRRRTQPPPPLTQKRRHVPEYLLLRPTMAYLQHSFHVRWLESFLGDVYGVLRAAGLESKFTATPYASVDLAHIDRSVPTVEGLVKQFLLPLESTFSADLITPQTSFNVKTRTNLLVPPFGTHFEIALNMPHYPDVQPPSRIGQHDQVAMMVTHFLLLDIVSTISHGQGQPVKSETKTTPLSWEVTYPHHGELLAVASDGRQKKMKVQLSRSELSVQMFETHGTDSYSRLVGAEGGMLPLPSQSQTWTADAATPHPSLMEFVASVSKSA
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 17, Mediator complex subunit 17.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 17 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DLLA_DANRE
Sequence: MGRHLLLLLFSILYMLLCQASSSGVFELKLQEFLNKKGVQGNKNCCKGGLTTSYQQCECKTFFRICLKHYQPNASPEPPCTYGGTVTPVLGSNSFQVPDTLPDGSFTNPIRMNFGFTWPGTFSLIIEALHADSKEDLTTENPERIISTMTTQRHLTVGEDWSQDLHSVGRTELKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEIICDAGWKGQYCTEPICLPGCDEEHGFCEKPGECKCRVGFKGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCLNGATCSNTGQGSYTCSCRPGFSGASCEIEVNECTGNPCRNGGSCTDMENTYSCTCPPGFYGKNCELSAMTCADGPCFNGGRCADNPDGGYFCQCPTGYAGFNCEKKIDHCSSSPCSNGARCVDLVNSYLCQCPDGFTGMNCDRAGDECSMYPCQNGGTCQEGASGYMCTCPPGYTGRNCSSPVSRCQHNPCHNGATCHERNNRYVCACVSGYGGRNCQFLLPDRASQIASDVPWTAVGSGVLLVLLLVVACAVVVVCVRSKVQQRRRDREDEVANGENETINNLTNNCHRDKDLAVSVVGVAPVKNINKKIDFSSDHDDLSLTTEKRSYKTRHAPADYNLVHEVKFEVKHEVKLEHAGKETTMANELSDSCEDIKCQSLQDSSECTEEKRRKRLKSDASEKSKYSESRYSESKYSESKYSESKYSDVSLYSESACASACASASTSACVDTKYKSVMVMSEEKDECVIATEV
What is the function of this protein?
Acts as a ligand for Notch receptors and is involved in primary neurogenesis.  Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation.  Required for boundary formation during segmentation of the hindbrain.  Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord.  In inner ear, it prevents adjacent cells from adopting the same cell fate.  Plays a role in angiogenesis.
What are the official names of this protein?
Delta-like protein A, DeltaA.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ATPA_STAA8
Sequence: MAIKAEEISALLRSQIENYESEMSVTDVGTVLQIGDGIALIHGLNDVMAGELVEFHNGVLGLAQNLEESNVGVVILGPYTGITEGDEVKRTGRIMEVPVGEELIGRVVNPLGQPIDGQGPINTTKTRPVEKKATGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIAIDTILNQKDQGTICIYVAIGQKDSTVRANVEKLRQAGALDYTIVVAASASEPSPLLYIAPYSGVTMGEEFMFNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDLGGGSITALPIIETQAGDISAYVPTNVISITDGQIFLQSDLFFSGVRPAINAGQSVSRVGGSAQIKAMKKVAGTLRLDLASYRELESFAQFGSDLDEFTASKLERGKRTVEVLKQDQNKPLPVEHQVLIIYALTKGYLDDIPVVDITRFEDELNHWAESNATELLNEIRETGGLPDAEKFDTAINEFKKSFSKSE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HYAL_TITST
Sequence: EHPALYRRYSKEHTFCKTKNQXCN
What is the function of this protein?
Possesses high activity against hyaluronan in vitro.
What are the official names of this protein?
Hyaluronidase, Cysteine-rich venom protein, CRVP, Hyaluronoglucosaminidase A.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: DER_SALPA
Sequence: MVPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEVEGREFICIDTGGIDGTEDGVETRMAEQSLLAIEEADVVLFMVDARAGLMPADEAIAKHLRSREKPTFLVANKTDGLDPDQAVVDFYSLGLGEIYPIAASHGRGVLSLLEHVLLPWMDDVAPQEEVDEDAEYWAQFEAEQNGEEAPEDDFDPQSLPIKLAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDEREYVLIDTAGVRKRGKITDAVEKFSVIKTLQAIEDANVVLLVIDAREGISDQDLSLLGFILNSGRSLVIVVNKWDGLSQEVKEQVKETLDFRLGFIDFARVHFISALHGSGVGNLFESVREAYDSSTRRVSTAMLTRIMTMAVEDHQPPLVRGRRVKLKYAHAGGYNPPIVVIHGNQVKDLPDSYKRYLMNYFRKSLEVMGTPIRIQFKEGENPYANKRNTLTPTQMRKRKRLMKHIKKSK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: DER_NITHX
Sequence: MSFTIAIIGRPNVGKSTLFNRLVGQKLALVDDKPGVTRDRREGQARLGDLDFTVIDTAGLDEGPRGSLTARMQEQTETAIAAADALMFVFDARAGLTPTDRSFADFARRANKPVVLVANKSEGRHGEAGALESYALGLGDPVGVSAEHGEGMSDLYDALRGVMPEPTEEAEEFDDDDIIESEDISQRPIRVAIVGRPNAGKSTLINYLLGEERLLTSPEAGTTRDSISVELNWQGRDFRIFDTAGLRRRSRIEEKLEKLSVADTLRAARFAEVVVLMMDAQNRFEEQDLRIADLIEREGRALVIAVNKWDLMGRQSSLIAALRTDADHLLPQVKGMPIVAVSGLMGEGVDRLMTAIQDAYAIWNRRVPTAALNRWFEQAVDANPPPAVSGRRLKLNYVTQAKARPPSFIVFCSRADAVPESYLRYLVNSLRGFFDLPGTPIRITLREKANPFAHKRKRKS
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RBFA_SHEAM
Sequence: MAREFSRTRRIGQQLQQELAFVLQRDMKDPRIGMVTVNDVDVSRDLSHAKVYVTFFEEDPQVIEAKLAALNTAAPYARTLVAGRMKLRVMPELRFIYDASLVEGMRMSNLVSKVIRDDEAKKGHIGDEPQEGQREED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLD_PECCP
Sequence: MAKNYYEITLALAGICQSAHVVQQLAHTGHCNNDVLHTSLNSVLNLNPSSTLAVYGNDEQNLKVGLETLLGILNTSSNKGAGAELSRYAFSLIALERKLKAKPAALDELGKRIGQLERQLEHFDLLSETIVSALAAIYVDVISTLGPRIQVTGSPEVLKNSQVQAKVRSALLAGIRSAVLWQQIGGGRLQLMFSRGQLVKEAKQILARCPSV
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MAO1_ECO57
Sequence: MEPKTKKQRSLYIPYAGPVLLEFPLLNKGSAFSMEERRNFNLLGLLPEVVETIEEQAERAWIQYQGFKTEIDKHIYLRNIQDTNETLFYRLVNNHLDEMMPVIYTPTVGAACERFSEIYRRSRGVFISYQNRHNMDDILQNVPNHNIKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRNPRITDDEYYEFVDEFIQAVKQRWPDVLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRAAGGQLSEKKIVFLGAGSAGCGIAEMIIAQTQREGLSEEAARQKVFMVDRFGLLTDKMPNLLPFQTKLVQKRENLSDRDTDSDVLSLLDVVRNVKPDILIGVSGQTGLFTEEIIREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFNPVVWKDKIYPIAQCNNAFIFPGIGLGVIASGASRITDEMLMSASETLAQYSPLVLNGEGLVLPELKDIQKVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWQAEYRDYRRTSI
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: F149B_DANRE
Sequence: MISRYSRRPVSHNLEIRGLSRSCLDQHPLPEEADNGTAHSSRLLHNLQEDMSLYSRSEESSASSVRSGCQTLTTDDTVPSWSGIHSYTGTGISTERSSVFSWGYDEFDKAASRQVQQMFEEIDELLYERKCETQLKGLQDECQEWAFRFPHLRILGTQVVCPTDEGFQWYATPAQTPSPSSSFQSKENTVSELYVQGRRAVLCRPTVEVTNPSIRTSGNNEDELPSVIEAEGLIEEYLAYDCRDMDEECEREYVSRRRRRRRCLPPVSPYRCRQEAVLDMLFDDVWRELIGWIEELVRKHWDGYVLDDEKSTVALSPKCPDPQNPFMLPSNVSTVLPPLSQTRTQQLTTNLQAQTSRVPVGPAVAHHNLNDLIMIHGIPLQQRNLGTLDRLNQSDCRDSEDKVSHRPGSSVIPAGKPRPRRALDQSTSSLTRPPQSARRRNPPPRNLMPITSSVTQPITTMEEVVRGTRLTTPSDRLTSPPMHLSRNTLLPPIGTGDIDHVYSGQHTRLIQKQRGSSSRAHSAVTDEGISLQPRDKLHLLDVFSRPNTTHTFRSDTPYHRSFTGIDNIGQGRPGRASVGVDSLGIGVTGISLGISSSSFIDSFSHRPMGHFPIGHEEEPDAKASGQARSHNRGGSTARSSRPGL
What are the official names of this protein?
Protein FAM149B1.
What is the protein family that this protein belongs to?
Belongs to the FAM149 family.