PharMolix/UniProtQA huggingface dataset:
Protein: HGP2_HAEIN
Sequence: MTNFRLNVLAYSVMLGLTAGVAYAAQPTNQPTNQPTNQPTNQPTNQPTNQPTNQNSNVSEQLEQINVSGSTENSDTKTPPKIAETVKTAKTLEREQANNIKDIVKYETGVTVVEAGRFGQSGFAIRGVDENRVAINIDGLRQAETLSSQGFKELFEGYGNFNNTRNGAEIETLKEVNITKGADSIKNGSGSLGGSVIYKTKDARDYLINKDYYVSYKKGYATENNQSFDTLTLAGRYKKFDVLVVTTSRNGHELENYGYKNYNDKIQGKKREKADPYKIEQDSTLLKLSFNPTENHRFTFAADLYEHRSRGQDLSYTLKYQRSGNETPEVDSRHTNDKTKRRNISFSYENFSQTPFWDTLKLTYSDQRIKTRARTDEYCDAGVRHCEGTDNPTGLKVTNGKITRRDGSDLQFEEKNNTAKSSDKTYDFKKFIDTDKRVIDDKLVLNNPSDTWYDCSIFNCENNAKIKVFKGNNYYGYDGKWKEVDLEIKELNGKKFAKIKDNDRKIKSILPSSPGYLERLWQERDLDTNTQQLNLDLTKDFKIWHIEHNLQYGGSYNTAMKRMVNRAGNDASDVQWWATPTLGEDSWTGKPHTCATTYEWNANLCPRVDPEFSYLLPIKTTGKSVYLFDNFVITDYLSFDLGYRYDNIHYQPKYKHGITPKLPDDIVKGLFIPLPNNSNSDPNKVKENVQQNIDYIAKQNKKYKAHSYSFVSTIDPTSFLRLQLKYSKGFRTPTSDEMYFTFKHPDFTILPNTDLKPEIAKTKEIAFTLHNDDWGFISTSLFKTNYKNFIDLIFKKQETFKVGGSGRGETLPFSLYQNINRDNASLKGIEINSKVFLGKMAKFMDGFNLSYKYTYQKGRMNGNIPMNAIQPRTMVYGLGYDHPNHKFGFDFYTTHVASKNPEDTYNMFYKEENKKDSTIKWRSKSYTILDLIGYVQPIKNLTIRAGVYNLTNRKYITWDSARSIRSFGTSNVIDQSTGLGINRFYAPGRNYKMSVQFEF
What is the function of this protein?
Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.
What are the official names of this protein?
Probable hemoglobin and hemoglobin-haptoglobin-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the TonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: TP1A_HADIN
Sequence: NECIRKWLSCVDRKNDCCEGLECYKRRHSFEVCVPIPGFCLVKWKQCDGRERDCCAGLECWKRSGNKSSVCAPIT
What is the function of this protein?
This toxin potently and selectively inhibits ASIC1a (IC(50)=0. 4 nM on rASIC1a and IC(50)=0. 52 nM on hASIC1a), an isoform of the gene ASIC1 (PubMed:28320941).  It incompletely inhibits ASIC1a activation in a pH-independent and slowly reversible manner (Tau(off)=14. 2 min for rASIC1a and 31. 8 min for hASIC1a) (PubMed:28320941).  This toxin acts by binding to and stabilizing the closed state of the channel, thereby impeding the transition into a conducting state (PubMed:28320941).  This toxin may bind to the acidic pocket of ASIC1a, since mutation of a key residue of this pocket (Arg-350) abolishes the ability of the toxin to inhibit ASIC1a (PubMed:28320941).  In addition, it shows antiparasitic activities, since it moderately inhibits the larval development of the major pathogenic nematode of ruminants (H. contortus, IC(50)=22. 9 uM) (PubMed:31213240).  In vivo, this toxin protects the brain from neuronal injury when administered up to 8 hours after stroke onset (PubMed:28320941).
What are the official names of this protein?
Pi-hexatoxin-Hi1a, Pi-HXTX-Hi1a, Double-knot toxin, DkTx.
What is the protein family that this protein belongs to?
Belongs to the psalmotoxin-1 family. Double-knot toxin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PFDB_SULIM
Sequence: MAEKLPPEVQAQLAKFQQLKDQLDRLLLEKSTIENELREINKVLEELSVLNADATIYKIVGNLLVKSDKTSVEKELNDRKELLELRSRTYQKQESILRKQLEDLQAKINEMLSKYYPQGGQTGIKA
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_BLOFL
Sequence: MKKVIVGISGGVDSSVAAWLLQQQGYLVEGLFMKNWENDDEKEYCSSEEDLSDAWSICNTLKIPLHTVNFAQEYWENVFQVFLQAYQSGFTPNPDVLCNKEIKFKHFLDFALEDLGADFIATGHYVRCMNVKKKITLMKGIDQNKDQSYFLYTLNQQQLKRCLFPIGSLTKLTVRKIAKELNLITANKKDSTGICFIGKRNFRSFLSNYIAIQPGDIINIHGNKLGLHQGIPFYTIGQRKGLNIGGISNGNGKPWYVVDKNITHNVLIVAQGINHPCLMSRIFIVQKIFWIKGNILKSPIQCSVKIRYQQSDVQCQIYPISVDTLKIILKQPVTAIAPGQSAVFYIKKHCIGGGTIIKRFPLIHIKNYY
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_BUCAT
Sequence: MTDNVLKLSRKNIKKLIPYQSARRIGGEHGNILLNANESPVSIFFKLKKKPFNRYPECQPSKLISSYAHYVNLSCNQILATRGADEGIELLIKAFCEPGKDAIIYCPPTYDMYRINATIAGVEIKEIPTIKNTWQLDLLNIKLNLSRVKLIYICNPNNPTGNIFFKKDLIFLLNITLGQALVVIDEAYIEFSPEESMTNYLKDYPNLVVLRTLSKAFALAGIRCGFTLAKKEIIQTLSKVISPYPISIPVSDIAIRSLEKDYVQLMKNRVLDSNNNRIWLINQLKNITCVETVFESNANYVLVKFSMFEKVFETLWNKGIILRNQNEKMNLKKCIRISMGTRSESLRLIKELKIFSKKNMCQGEMSEK
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: COX41_RABIT
Sequence: MLPTRLLSFSGSRAISTSFCLRAHGSVVKSEDYALPSYVDRRDYPLPDVAHVKQLSAGQKALKEKEKAPWGSLTRDEKVELYRIQFNESFAEMNRGTNEWKTVVGTALFFIGFTALILIWEKHYVYGPIPHTFDKEWVAMQTKRMLDMKVSPIQGFSAKWDYNKNEWRK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial, Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit IV isoform 1, COX IV-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase IV family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ACND_SHEON
Sequence: MSTVMNTQYRKPLPGTALDYFDTREAIEAIAPGAYAKLPYTSRVLAENLVRRCEPEMLTASLKQIIESKQELDFPWFPARVVCHDILGQTALVDLAGLRDAIAAKGGDPAQVNPVVPTQLIVDHSLAVEYGGFDKDAFAKNRAIEDRRNEDRFHFINWTQKAFKNIDVIPQGNGIMHQINLERMSPVIHARNGVAFPDTLVGTDSHTPHVDALGVIAIGVGGLEAESVMLGRASYMRLPDIIGVELTGKPQPGITATDIVLALTEFLRAQKVVSSYLEFFGEGAEALTLGDRATISNMTPEFGATAAMFYIDQQTLDYLTLTGREAEQVKLVETYAKTAGLWSDDLKQAVYPRTLHFDLSSVVRTIAGPSNPHARVPTSELAARGISGEVENEPGLMPDGAVIIAAITSCTNTSNPRNVIAAGLLARNANAKGLTRKPWVKTSLAPGSKAVQLYLEEANLLPELESLGFGIVGFACTTCNGMSGALDPVIQQEVIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDVLGLDKDGKPVRLINIWPSDAEIDAVIAASVKPEQFRKVYEPMFDLSVDYGDKVSPLYDWRPQSTYIRRPPYWEGALAGERTLKGMRPLAVLGDNITTDHLSPSNAIMMDSAAGEYLHKMGLPEEDFNSYATHRGDHLTAQRATFANPKLKNEMAIVDGKVKQGSLARIEPEGIVTRMWEAIETYMDRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKAGENRATYGIDGTEVFDVIGSIAPRADLTVIITRKNGERVEVPVTCRLDTAEEVSIYEAGGVLQRFAQDFLESNLK
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle II (propionate degradation route).  In vivo under anaerobic conditions, AcnD catalyzes the stereospecific dehydration of (2S,3S)-methylcitrate (2-MC) to yield the trans isomer of 2-methyl-aconitate (2-MCA).  AcnD can also accept citrate and cis-aconitate, but with a lower efficiency.  2-methylisocitrate and isocitrate are not substrates.
What are the official names of this protein?
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming), Aconitate hydratase, ACN, Aconitase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: TATA_BACC1
Sequence: MFSNIGFPGLILILVAVLILFGPKKLPEIGKALGETLKEFKKSTKELTDDAFQEKEKKEKM
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: UVRC_ANAD2
Sequence: MDANLRRKLDELPAEPGCYLMKDRAGEVVYVGKASSLRSRVRSYFDPGRGDQRAFVALLDELLGDLEVIVTRSEKEAVLLENELIKKHRPRFNVRLRDDKDFIVLKLDERHPYPRLEVRRAREKRQPGARYFGPYSSASSIRETLRMVNRHFQLRTCSDHVFDHRKRPCILYQIHRCPAPCVYEVAAEEYRQSVEDAVEFLEGREGELVERLRGRMAGAAEGLRFEEAARLRDQLQAVERSLEKQRVLMSDRGDRDVIGLYREGPDLVVQVLSMRAGKLQDAQAHPFREQEFPDEEILSSFLSLYYEHTDAPDEILVPLEPVQAEALADVLSERRGRRVRLLTPQRGAKADLLDVARRNAEQGFRAWHEHDERREQALAAVARALHLARPPRWMECYDISTFQGALAVGSGVSMKDGEPDKANYRRYKVKAVAGQDDFAMLHEVITRRLRRALGEGQLPDLIVIDGGKGQLNAALAAAKDLGVPTRPSPGNPDAPFVELVGLAKSRLVDGPSLGTARVVGRRGRRAEARLADAAEAAEKGFVSELARSPERVFLPGRKDPVVLRQNSAELFLLARLRDEAHRFAITFHRKLRRERNFQSVLEEIPGIGEGRKRALLRHFGALRRVREATPEEIAQVEGFGPRQAAAVHAFFHRPDAPPIAADEPSGAPAGAPGGGPAEASPEAVAAATEAEIDAALADEDASPEPAA
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_BURCJ
Sequence: MEVKAIHRGARISAQKTRLVADQIRGLPVDKALNVLTFSPKKAAGIVKKVVLSAIANAEHNEGADIDELKIKSIYVDKAASLKRFTARAKGRGNRIEKQSCHITVTVGN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: LGT_XYLF2
Sequence: MIYLHAIDPIAFSLGPVKVHWYGLMYLAGFGAAWCLGRQRIQAGRLLGVNIDGFSDLLFYAMMGVVLGGRVGYMLFYAFHDFLQEPLLLFRVWEGGMSFHGGLIGVLLAVAWWSRRQRMHMFDVVDFCAPLVPVGLGFGRLGNFIGGELWGKLTHNGWGVIFPRAPLSDVPAGQLAMQDVINFVQIQEHYAAGLLGHYARHPSQLYEAFLEGLVMFIVLWLFSRKPRPRYAVSGLFALLYGVFRFLVEFVRMPDNGVYVAFGWLTRGQILSLPLIVIGLFLFWLSCRSPVLQPVPAPEVAK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MEND_ROSCS
Sequence: MPNRNILYATTLVDELARAGLRHVCLAPGSRNTPLVLAFARHPAIRVFSHLDERSAAFFALGLALATDTPAAVVCTSGSAAANFFPAIVEAHQAGVPLLALTADRPHELRDSGANQTIDQVKMFGSFARWSVDVALPEAMPPPVALRNLRTLAARAMAIAGGEPRGVVHLNLPFRPPLEPTPMPGDLTEPPAAAQPRDDGAPYTCFLRSAPPAPPEAVIEPIAAVLEQHERGLIVCGPRCPGGAFGALVSELSQRTGYPALVDGVSGVRFGYPGVIGGYETFLFGEHAFPPPEVVLRFGAVLTSKWLNQYLDTAASPVVIHVRASGVWADDSHRVSHFVVADEAAFIRALIPRLTERQSAWRQRFVEAEARVWAAVEAGIADEPYFDGGAVYDVIDLLPEGASLFVGNSLPVRHLDQFGKPGVRHICAFANRGASGIDGNISTALGIGAGRPDAPLAAIVGDITFYHDMNGLLAVRRCGVPATIVLLNNDGGGIFHRLPINRFEPEFTDYFVTPHGLDFAHAAKMYGLEYVPVKDRTAFRSAFRASIDARAATLIELRTDARTDLVRRNALIQAARATGA
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: SEBP3_ARATH
Sequence: MEAAMNNHDGDCCKSGPGYATPLLAMSGPREKLIYVAAIYTGTGQAKPDYLATVDVEPSSSTYSSVIHRLPMPYLEDELHHSGWNSCSSCYGDSSCERRYLILPSLLSGRIYVIDTKTNPREPSLHKFVDPAEVLEKTGLAYPHQPHCLASGDVLVSCLGDEDGNAEGSGFLLLDSEFNIKGRWEKDGNSPLYGYDFWYQPRHKTMISTSWGAPAAFTKGFDLKDVSDGLYGKHLHVYSWPQGELKQILDLGDTGLLPLEVRFLHEPDKATGFAGCALSSTLVRFFKNDDETWSHEVAISVEPLKVENWILPEMPGLITDFLISLDDRFLYCSNWLHGDIRQYNIEDPKTPVLTGQIHVGGLVQKGSLVLALGEEGKAFQFDVPKIKGQRLRGGPQMFQLSLDGKRLYVTNSLFSVWDRQFYPELVEKGSHMLQIDVDTDKGGLSINPNFFVDFGTEPDGPSLAHEMRYPGGDCTSDIWV
What are the official names of this protein?
Selenium-binding protein 3.
What is the protein family that this protein belongs to?
Belongs to the selenium-binding protein family.
Protein: Y1764_SYNY3
Sequence: MLSLEKGQSLSLTKPDGSSIQKVRVGLSWDVASIGSNVDLDLFVVHKESKKVAFFNDKTAISGIKLSDDNLTGEGEGDDEFTELDATKTDDGDYYICVNIYDAKSRKQAFNLVNNAKATIYNNETNTALASYSITEDGGQNTGIIVAKLKDVGGSYEFTALGEYIVGDINEIAQVVFRK
What are the official names of this protein?
Uncharacterized protein slr1764.
What is the protein family that this protein belongs to?
Belongs to the CAPAB/TerDEXZ family.
Protein: YPHG_ECOLI
Sequence: MTPVKVWQERVEIPTYETGPQDIHPMFLENRVYQGSSGAVYPYGVTDTLSEQKTLKSWQAVWLENDYIKVMILPELGGRVHRAWDKVKQRDFVYHNEVIKPALVGLLGPWISGGIEFNWPQHHRPTTFMPVDFTLEAHEDGAQTVWVGETEPMHGLQVMTGFTLRPDRAALEIASRVYNGNATPRHFLWWANPAVKGGEGHQSVFPPDVTAVFDHGKRAVSAFPIATGTYYKVDYSAGVDISRYKNVPVPTSYMAEKSQYDFVGAWCHDEDGGLLHVANHHIAPGKKQWSWGHSEFGQAWDKSLTDNNGPYIELMTGIFADNQPDFTWLDAYEEKRFEQYFLPYHSLGMVQNASRDAVIKLQRSKRGIEWGLYAISPLNGYRLAIREIGKCNALLDDAVALMPATAIQGVLHGINPERLTIELSDADGNIVLSYQEHQPQALPLPDVAKAPLAAQDITSTDEAWFIGQHLEQYHHASRSPFDYYLRGVALDPLDYRCNLALAMLEYNRADFPQAVAYATQALKRAHALNKNPQCGQASLIRASAYERQGQYQQAEEDFWRAVWSGNSKAGGYYGLARLAARNGNFDAGLDFCQQSLRACPTNQEVLCLHNLLLVLSGRQDNARVQREKLLRDYPLNATLWWLNWFDGRSESALAQWRGLCQGRDVNALMTAGQLINWGMPTLAAEMLNALDCQRTLPLYLQASLLPKAERGELVAKAIDVFPQFVRFPNTLEEVAALESIEECWFARHLLACFYYNKRSYNKAIAFWQRCVEMSPEFADGWRGLAIHAWNKQHDYELAARYLDNAYQLAPQDARLLFERDLLDKLSGATPEKRLARLENNLEIALKRDDMTAELLNLWHLTGQADKAADILATRKFHPWEGGEGKVTSQFILNQLLRAWQHLDARQPQQACELLHAALHYPENLSEGRLPGQTDNDIWFWQAICANAQGDETEATRCLRLAATGDRTINIHSYYNDQPVDYLFWQGMALRLLGEQQTAQQLFSEMKQWAQEMAKTSIEADFFAVSQPDLLSLYGDLQQQHKEKCLMVAMLASAGLGEVAQYESARAELTAINPAWPKAALFTTVMPFIFNRVH
What are the official names of this protein?
Uncharacterized protein YphG.
Protein: NAGB_ECO8A
Sequence: MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMELKVKTLRYFNELEAENIKGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: RL1A_YEAST
Sequence: MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQRDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKKLSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLKKVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.
What are the official names of this protein?
60S ribosomal protein L1-A, L10a, Large ribosomal subunit protein uL1-A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_PROM3
Sequence: MSLRLTNTLTRRTEPFTPLKDGHVSIYCCGVTVYDLCHLGHARSYIAWDVLRRYLLWRGYSVTFVQNFTDIDDKILKRAAEKKCSMEHISEQNIEAFHQDMDALGILRPDRMPRATQCLDGIRALIGELETSGAAYSVDGDVYFAVMKHHGYGKLSGRDLNEQQQNADGRVADAEEARKQHSFDFALWKGAKTGEPSFPSPWGAGRPGWHIECSAMVREELGETIDIHLGGADLIFPHHENEIAQSEAATGKQLARYWLHNGMVNVGGQKMSKSLGNFTTIRALLESGVSPMTLRLFILQAHYRKPLDFTADAINAAATGWKGLNAALGLGNIYAEALNWPECKPLPQEVMQPAHSSTLEQCSEIRQHFIDALDDDLNSSGAIAVLFDLARPLRALANRLERGDTKAIQETAQLNLLPRWQLLVELANVLGLEAEKAAKLAPEGNNRVDENHIQLAIAARKEAKAARDFAKADRIRDELRAQGIELIDKPGGLTDWISS
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPZ2_HUMAN
Sequence: MQRPEAWPRPHPGEGAAAAQAGGPAPPARAGEPSGLRLQEPSLYTIKAVFILDNDGRRLLAKYYDDTFPSMKEQMVFEKNVFNKTSRTESEIAFFGGMTIVYKNSIDLFLYVVGSSYENELMLMSVLTCLFESLNHMLRKNVEKRWLLENMDGAFLVLDEIVDGGVILESDPQQVIQKVNFRADDGGLTEQSVAQVLQSAKEQIKWSLLK
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.  The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
What are the official names of this protein?
Coatomer subunit zeta-2, Zeta-2-coat protein, Zeta-2 COP.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum- Golgi intermediate compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network.
Protein: RL35_BACHK
Sequence: MPKQKTHRGAAKRFKKTGSGKLKRSHAYTSHLFANKSTKAKRKLRKAGVVSAGDFKRIRQMLDNLK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: HSPQ_SHISS
Sequence: MIASKFGIGQQVRHSLLGYLGVVVDIDPVYSLSEPSPDELAVNDELRAAPWYHVVMEDDNGLPVHTYLAEAQLSSELQDEHPEQPSMDELAQTIRKQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OLR1_PIG
Sequence: MTLDDLKSNSMKDQPDEKSNGDKAEGPRSLSTLRWRPAALILGLLCLGLLVTVILLIIQLSQVSDLLKQQKVKLTHQEDILEGQALAQRQAEKSSQESQRELTEMIETLAHKLDEKSKKLMELQQQNLNLQKALEKAANFSGPCPQDWLWHEENCYKFSSGPFSWEKSRENCLSLDAQLLKINSTDDLEFIQQTIAHSSFPFWMGLSLRKPNNSWLWEDGTPLMPHLFRLQGAASQMYPSGTCAYIHRGIVFAENCILNAFSICQKRANLLRAQ
What is the function of this protein?
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells.  OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis.  Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis.  In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation.  Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.  Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).
What are the official names of this protein?
Oxidized low-density lipoprotein receptor 1, Ox-LDL receptor 1, Lectin-like oxidized LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation (By similarity).