PharMolix/UniProtQA huggingface dataset:
Protein: NDX8_CAEEL
Sequence: MKCVVSRADDLKRMLDLSDVPTKSQGEQDAGVLILLHDDGSEKLKVLLCVRSRQLRRHPGEVCFPGGMMDDEDGQNVRRTAIREAYEEVGVNENDDYLVLGNLPAFRARFGVLIHPTVALLRRPPTFVLSIGEVESIFWIPLSQFLEDTHHSTFLIDEFYMVHVFQFDEYPTTYGVTALMCIVVAIGLLGKLPNFNLMGNLTISDMLDKHLDSIEIIRHVYEFASRKFEPKSKI
What is the function of this protein?
Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine.
What are the official names of this protein?
Peroxisomal coenzyme A diphosphatase ndx-8, Nudix hydrolase 8.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: RSA2_CAEEL
Sequence: MSKIPVFKGSFKSWLAKNDEKPAKSVLLEPKYRDHHEKISFRNKENMEEGEKPVFVSMANPQPTREDYERYDEDRRLKDKARDLRIARRRNSATPEASPSSDQYFTPEPADDEFVTPSTSKKSQKPRSSDATPVSSKPPRYLPRTPLSEQYTSCLSRKMEENFSRMQELMISGHSPHEARQQTIQESSEQLEPRAKVTRSSSQPPPIDTLKPRVPRIESPLVKKTTETPIRRTSYVDTLVATHQIQLQYSDRVVVGVERQMTKLESIKNLAAANRSPIIAEEAKKRRNEAEAVRKLIEVETQNAKKRAVIQELKDRIDKLTQAQLAIHQLVSSQPFSGDPYNQRLLRSIDNWMALPFREFDIQTAREMLELARKMKITIDHFRNVATLHRNSKSLNRSLNTSRKSIAVKINPSSQLNQQSSSDAAPPPSMREASTQMTSRLAESAMTQTSPRRIGVEPLDLSQLLEKHNSSSQTTPPVVEPVLAEVSAEPQRPPVTLSMTAPVSTIAEFDSMLNSISLHNESLETVAEPFSRLKTDISFPSTVEETTPRSGRVSLDSESARRLSAGLSHYLEQVKKERESMEAQESESESMELEIPVVSEVSVTTESENLEEVVSEHSDSKSPETLVASDNGEDSSGGSEDPNATQFEHEIEEHKEPEKLGLIIDPEDEQDETKRFVNHDEFEQSLEEELEPRGNNDSADDSGFLLDNSPAPRLKSIFDNLPPAAASAAVTDTPRVPAEADETTFAGMDMEEYCQREFLKEISPIMVQKAIELQDELRGVDWLTAQDVWQPPSFKDVQMEFDDNFEYFDSFSILIWSAVVDLINKNYLKFGRKMTENEEIAFEAEALKMLQTEHGPESRKSEWCTDVKMSKKLEGMMPMELDYRYDVRRGLPDAEKQKYQWQQVQMTVIAARYANKNLINEANEVYATEKEKLGQMVLESEIDATVTDV
What is the function of this protein?
Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes (PubMed:17218259).  Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions (PubMed:25819561).
What are the official names of this protein?
Regulator of spindle assembly protein 2.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: MURQ_PROM3
Sequence: MTNLFEHINLHPSDDRGHLLTEQVNPKSECLDQLSTESLVTLFCEEDREPQRAVAAAIPELIQAVEAITDRLRSGGRLFYLGAGTSGRLGVLDAAECPPTFCSDPDLVQGVLAGGSSALLKSSEGLEDIEQAGQKDLQQRGFSSADCLVGIAAGGTTPYVKGGLAYAKEINALAIAISCVPIEQAELPCSIDIRLLTGPELLTGSTRLKAGTATKMALNILSTCAMVRLGKVFGNRMVDVAATNIKLMDRALRILHDLADVDRDRGSELLQASDGSVKVALLMHACGLDAEAAQKLLIEQNNQLRTALASCGNCIS
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: RL34_ALKOO
Sequence: MKRTYQPKKRQRSKEHGFRKRMSTSTGRNILKARRLKGRKRLTA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RSMG_CUPPJ
Sequence: MGGQRHTMIDDAAQRRRLEAGLAEIGLALPPDRIDTLFAYLALLRKWNGVYNLTAIRHPDEMLTHHLLDSLAAVPALAEMARSSEVGGAARGRVLDVGSGGGMPGLPLAISCPDVSVLMVDIVQKKTAFLTQCRAQLGLSNAAAHWGPVERLEDPDKFAVITSRAFAELTDFVNLSGHLLAPHGRLIAMKGVYPQAELDRMEAAGLMAAWQVEEVRRLTVPGLDAERHLVLLSRK
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR8K3_HUMAN
Sequence: MEQHNLTTVNEFILTGITDIAELQAPLFALFLMIYVISVMGNLGMIVLTKLDSRLQTPMYFFLRHLAFMDLGYSTTVGPKMLVNFVVDKNIISYYFCATQLAFFLVFIGSELFILSAMSYDLYVAICNPLLYTVIMSRRVCQVLVAIPYLYCTFISLLVTIKIFTLSFCGYNVISHFYCDSLPLLPLLCSNTHEIELIILIFAAIDLISSLLIVLLSYLLILVAILRMNSAGRQKAFSTCGAHLTVVIVFYGTLLFMYVQPKSSHSFDTDKVASIFYTLVIPMLNPLIYSLRNKDVKYALRRTWNNLCNIFV
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 8K3, Olfactory receptor OR11-181.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: G6PI_PONAB
Sequence: MAALTRDPQFQKLQQWYREHGSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDIINIGIGGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSVSIIASKTFTTQETITNAETAKEWFLQTAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKVLLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDASTNGLINFIKQQREARIQ
What is the function of this protein?
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity).  Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility.  Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons.  It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Autocrine motility factor, AMF, Neuroleukin, NLK, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted.
Protein: GUAA_PARMW
Sequence: MSQSSSDGQRQPAIVILDFGSQYSELIARRVRETEVFSVVLGYSTSAEELRAMQPKGIVLSGGPSSVYAEHAPLCDPAIWELGIPVLGVCYGMQLMVQQLGGVVEAASGKAEYGKAPLEVDDPTDLLTNVTGGSTMWMSHGDSVKALPEGFVRLAHTANTPEAAVAHLQRRLYGVQFHPEVVHSTCGMALIRNFVYHICGCEPDWTTSAFIDEAVAVVREQVGEKRVLLALSGGVDSSTLAFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDRKFNIHVEYINARQRFISKLKGITDPEEKRKIIGTEFIRVFEEESKRLGPFDYLAQGTLYPDVIESAGTNVDPKTGERVAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGRALGLPEEIVRRHPFPGPGLAIRILGEVTDEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDKRTYAWPIVLRCVSSEDGMTADWSRLPYDLMETISNRIVNEVKGVNRVVLDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: TAT1_CAEEL
Sequence: MPTEARDNNRHIHLGKVRDPHHQHAQRFCSNRISTCKYNGFSFLPRFLYEQFRRYNNIFFLAIALLQQIPDVSPTGRYTTAVPFLIILSVSALKEIFEDVKRRRSDNKVNAFSVEILVDGHWIEKQWKDVSVGDFIRIDNDSLFPADLLLLASSEQQGMAYIETSNLDGETNLKIKQALDITSTMTSPEKLSQFESEITCEPPSRHVNEFNGNIEINGVARHFGIDQLLLRGARLKNTAWIFGAVIYTGHDSKLLMNSKRAPLKSGTIDVQTNYRIIFLFFVLVALALISATGSEIWRGNNIPQAWYLSFLEHDPKGSFLWGVLTFFILYNNLIPISLQVTLEVVRFFQAIYINNDIEMYDVNSDSCAIARTSNLNEELGQVKFIMSDKTGTLTRNVMKFKRLSIGSRNYGNNEDDEFADASLIEDYRQGDEHSTSILEVLKMMAVCHTVVPENKDGQLIYQSSSPDEAALVRGAASQSVSFHTRQPQKVICNVFGEDETIEILDVIDFTSDRKRMSVIVRDGAGGDIKLYTKGADTVIFERLEHGKEQEEAVEYCTEHLEDYASFGYRTLCFSMRHLTEQEYSQWAPEYKKAILAIDNRAKLLADAAEKLERNMILVGATAIEDKLQEWVPETIQALMAADIRVWMLTGDKRETAINIAHSCALCHTNTELLIVDKTTYEETYQKLEQFVARAIELEKQEKGFAMVIDGKSLLHALTGEARKHFGDLALRCHAVVCCRMSPMQKAEVVEMVRKLAKHVVLAIGDGANDVAMIQAANVGVGISGEEGLQAASASDYAIPRFHFLRRLLLVHGAWNHDRSVKVILYSFYKNICLYIIELWFAMFSAWSGQTIFERWTIGMFNVIFTAWPPVVLGLFDHPVPAEQIMKYPALYASFQNRAFSIGNFSLWIGLAIVHSLSLFFLTYATMEHQVVWDNGLTGGWLMLGNCAYTFVVATVCFKALLECDSWTWPVVVACIGSIGLWIVFVIVYSLVFPHIGGIGADMAGMAAIMMSSYTFWLALLFIPLATLLWDLVIKSLFTIAMPTPRELAVMYNKRTTSFNGFERLASYSSNVLENMRLLTSSLRGSTTGSTRSRTASEASLALAEQTRYGFAFSQDESSAVAQTELIRNVDSTREKPTGR
What is the function of this protein?
Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet (PubMed:18436785, PubMed:21170358, PubMed:23427264).  Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes (PubMed:18436785).  Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintenance and control of the membrane surface charge (PubMed:23427264).  Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo, likely with its chaperone protein chat-1 (PubMed:21170358, PubMed:23427264).
What are the official names of this protein?
Phospholipid-transporting ATPase tat-1, TAT-1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Colocalizes with its chaperone chat-1 at apical and basolateral cell membranes, on early endosomes and on recycling endosomes. Also localizes to intracellular tubular and vesicular structures.
Protein: GCM1_MOUSE
Sequence: MELDDFDPEDKEILSWDINDVKLPQNVKTTDWFQEWPDSYVKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETKLEAEARRAMKKVHMASASNSLRMKGRPAAKALPAEIPSQGSLPLTWSFQEGVQLPGTYSTPLIANAPQQNSLNDCLSFPKSYDLGGSTELEDPTSTLDSMKFYERCKFSSSRIYGSEEQFQPPVPGTYGDYEDLQTWNKNVALGRNPSDDIYYPAYPLPVASWPYDYFPSQNSLEHLPQQVPSEPPAAQPGCHPLWSNPGGEPYEEKVSVDLSSYVPSLTYHPPQQDPFLLTYGSPTQQQHALPGKSNRWDFDEEMACMGLDHFNNEMLLNFCSLR
What is the function of this protein?
Transcription factor that is necessary for placental development (PubMed:8962155).  Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes.  Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.  Binds to the SYDE1 promoter.  Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity).
What are the official names of this protein?
Chorion-specific transcription factor GCMa, GCM motif protein 1, mGCM1, mGCMa, Glial cells missing homolog 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLME_RHIME
Sequence: MTKSPIGGNRSGRKLGQKVKKGKLKASSRRWIERHINDPYVQRAQLEGYRARAAFKLLEIDEKHKILAGAKRIIDLGAAPGSWSQIAAKVTNSTDADPRVAAIDFLEMDPIPGVRFLQMDFLDPEAPENLKQAIGGAPDIVLSDMAAPTTGHRQTDHIRTMHLCEVAAHFAVEVLAEGGHFLAKTFQGGTERDLLNMLKQNFRQVVHVKPASSRAESVEMFLLAKGFKGRHALESDEPAEGAAEE
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_SHEFN
Sequence: MFYKLAQKVMFQMDPELAHNIAIGSLKMTGNNLLNCFYRQQVKSSPVTCMGLTFPNPVGLAAGLDKDGESIDAFHAMGFGHVEVGTVTPRPQAGNDQPRLFRLKPAKGIINRMGFNNKGVDNLVRNLMAKKSDIMVGVNIGKNKDTPVEQGKDDYLICMEKVYQYASYIAVNISSPNTPGLRSMQYGELLDDLLSSIKAKQTELAAKHGKYVPVALKIAPDLTSEEISAIADSLMSNQFDGVIATNTTLSRDTVTDLKHAEEMGGLSGKPLADLSTQVIKQLAICLQGKIPIIGVGGINSAADALAKFDAGSTMVQIYSGFIYQGPKLVDQIARAYCAK
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL25_RHIWR
Sequence: MSEVLDLSAEARERAGKGASRAIRREGRVPAVIYGEKQEPASIHVEEKVLMKLLHTGHFFNSVVMLDVGGKKVRTLPKDVQFHPVTDRPLHVDFLRIGEHTKVNVNVPVHFKDEELSPGLKRGGVLNVVIHDLGLSVDAAEIPEEIVISLKGLEVGESIHLSQVALPKGASAQDHEDITIATIVAPSALKSAEGEEAAEAGEEAAEG
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: PSBE_TOBAC
Sequence: MSGSTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTESRQGIPLITGRFDPLEQLDEFSRSF
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII), and is essential for PSII function (PubMed:12655396).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: LHX9_MOUSE
Sequence: MEIVGCRAENNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLTKGTQLNGRDAGMPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTATTLTDLTNPTVTVVTTVTSNMDSHEPGSPSQTTLTNLF
What is the function of this protein?
Involved in gonadal development.
What are the official names of this protein?
LIM/homeobox protein Lhx9, LIM homeobox protein 9.
What are the subcellular locations of this protein?
Nucleus.
Protein: CDPAS_SULIM
Sequence: MSIAYDLLLSILIYLPAFVANGSGPFIKRGTPIDFGKNFVDGRRLFGDGKTFEGLIVALTFGTTVGVIISKFFTAEWTLISFLESLFAMIGDMIGAFIKRRLGIPRGGRVLGLDQLDFVLGASLILVLMRVNITWYQFLFICGLAFFLHQGTNYVAYLLKIKNVPW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNPS1_HUMAN
Sequence: MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHRSRSSSNSSR
What is the function of this protein?
Part of pre- and post-splicing multiprotein mRNP complexes.  Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets.  The ASAP complex can inhibit RNA processing during in vitro splicing reactions.  The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis.  Enhances the formation of the ATP-dependent A complex of the spliceosome.  Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner.  Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.  Participates in mRNA 3'-end cleavage.  Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Also mediates increase of mRNA abundance and translational efficiency.  Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
What are the official names of this protein?
RNA-binding protein with serine-rich domain 1, SR-related protein LDC2.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
Protein: DXS_TREDE
Sequence: MTKNSLLSKIKGPEDIKLLSYNELKDLAVEIRKEILTVVGHNGGHLASNLGVIELTLAIHRVFSSPHDAVVWDVGHQSYTHKMITGRQSRFSTLRLWEGLSGFPKREESVHDAFNTGHASTSISAALGILEGKRLNKDSGKVIAVIGDGAMTGGMAFEALSNAGELKKDLIVIINDNKMSISKNTGAFSEYLSRLTVHEGYQRFKYLFDKAVGSIPLVGNKLNSIIWRLKRGMKGIFYKNNIFVDFGFEYVGPINGHNMRELEKVLKNVKKLNSPVVMLVETIKGKGYPLAEINPAAFHGIGPFNIADGKVEKNDAITFTQAFGKALVKAAEKNSKIAAITAAMESGTGLSLFHSKFPERFFDAGIAEGHAVTFAAGLASAGMKPVTAIYSTFLQRSIDQIIHDTSIQNLPVIFAIDRAGPVPADGETHQGLFDIALLRPVPNMTILCPASEKELELMLSWALMQDNPIAIRYPKADCPKEIPEFSQSIEKGRGVLIKNSDKSRILITCTGGMYNEVKEASAILAHRGLSTDIYNVRFAKPIDENYFLNITKDYSYILFVEDGMKIGSLSSYLESLILRYESNKTGSQSNKTGLQNKKTAVLAFEDMFFPHGTRSEIFKGAGVSAEHIVQAAELLFTETHTVSASTAIPVKEN
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: HTPX_ACICJ
Sequence: MPNLIRTGLLMAALTALFVAIGYWIGRGAGAAIALAFAAAGNFVAYWVSDRAVLAMYGAQPANQAAFPRLVAQVDRLASKAGLPPPRVYVIDNDQPNAFATGRNPQHAAIAVTTGLLGALDEAELAGVIAHELSHIRHRDTLTMTVTATLAGAIGMISNLAIFFGGSDERRSSPFAGIAGLLLLLLAPLTATLVQLAISRTREYAADARAASLTGQPLALARALMRIDEMARWVPNDDAERNPATASLFIVNPLSGTTFDTLFATHPPIRERVARLRHMAQFDVSKN
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGP_SALPA
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPTEQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVASKPFAERYFPNGVTRSSLLKAPAVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELESGELINLTPGLLQRRMLYWHRFAPESRMMRKVTDALLEYGHKVLRQD
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: KCJ15_HUMAN
Sequence: MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQRERELRTLLLQQSNV
What is the function of this protein?
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.
What are the official names of this protein?
ATP-sensitive inward rectifier potassium channel 15, Inward rectifier K(+) channel Kir1.3, Inward rectifier K(+) channel Kir4.2, Potassium channel, inwardly rectifying subfamily J member 15.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: M1_I56A2
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTTEAAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTVGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: ROP1L_MACFA
Sequence: MPLPDTMFCAQQIHIPPELPDILKQFTKAAIRTQPADVLQWSAGYFSALSRGDPLPVKDRMEMPTATQKTDTGLTPGLLKVLHKQCHHKQYVELTDLEQKWKNLCLPKEKFKALLQLDPCENRIKWINFLALGCSMLGGSLNTALKHLCEILTDDPEGGPARIPFKTFSYVYRYLANLDSDVSSSETESYLASLKENIDTRRNGMIGLSDFFFPKRNLLENRENSEDVGH
What is the function of this protein?
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.  Important for male fertility.  With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
What are the official names of this protein?
Ropporin-1-like protein.
What is the protein family that this protein belongs to?
Belongs to the ropporin family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cell projection, cilium.