PharMolix/UniProtQA huggingface dataset:
Protein: CYSG_ECODH
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDALNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMGERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: YCAD_SALPA
Sequence: MFTYTRPVMLLLCGLLLLTLAIAVLNTLVLLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIVNQQTQTRHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLRNAGQTPNPVAHI
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROQ_ACTPJ
Sequence: MKKILLLNGPNLNMLGKREPHIYGSQTLSDIEQHLQQSAQAQGYELDYFQANGEESLINRIHQAFQNTDFIIINPGAFTHTSVAIRDALLAVSIPFIEVHLSNVHAREPFRHHSYLSDVAKGVICGLGAKGYDYALDFAISELQKIQLGEMMNG
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RRF_ANASK
Sequence: MGTIADDILDDLHGRILKTLDQLRTELAAVRTGRASLHLLDNVRVDYYGTPTPLNQVATLSVPEARLIVVKPWEKSMIPPIEKAIRDGNLGLNPMSDKDLVRVPIPALTEERRKEIVKQVKHKGEEHKIAVRNVRREAKELIEVAEKDGDISGDDAEKALEKMQKETDEGVKKIDEIVAAKEKDVLQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR1_RHIEC
Sequence: MNQSHSFPTDDPLDGDTLHEECGVFGILGHPDAAALTALGLHALQHRGQEAAGIVSFDGKRFYQERHMGLVGDHYTNPMTLARLPGSISIGHTRYSTTGEVAMRNVQPLFAELEEGGIAIAHNGNFTNGLTLRRQIIATGAICQSTSDTEVVLHLIARSRHASTSDRFIDAIRQMEGGYSMLAMTRTKLIAARDPTGIRPLVMGELDGKPIFCSETCALDIIGAKFIRDVENGEVIICEIQPDGSISIDARKPSKPQPERLCLFEYVYFARPDSVVGGRNVYTTRKNMGMNLAKESPVDADVVVPVPDGGTPAALGYAQESGIPFEYGIIRNHYVGRTFIEPTQQIRAFGVKLKHSANRAMIEGKRVVLVDDSIVRGTTSLKIVQMIREAGAREVHIRVASPMIFFPDFYGIDTPDADKLLANQYADVEAMAKYIGADSLAFLSINGLYRAVGGEDRNPARPQFTDHYFTGDYPTRLLDKNGESMGNKLSMLASNG
What is the function of this protein?
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
What are the official names of this protein?
Amidophosphoribosyltransferase, ATase, Glutamine phosphoribosylpyrophosphate amidotransferase, GPATase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: CYF_CUSEX
Sequence: MQTINTFSWINQRITRSISVLLLVYIITRTSISSAYPIFAQRGYENPREATGRIVCANCHLANKPVDIEVPQAVLPDTVFEAVVRIPYDSQLKQVLSNGKKGGLNVGAVIILPEGFELAPPDRLSPQMKEKIGNLSFQNYRPNQKNIIVVGPVPGQKYSEITFPILSPDPATKKDAHFLKYPIYVGGNRGRGQIYPDGSKSNNTFYSATAAGIVSKIIRKEKGGYEITITDASDSHQVVEIIPPGPELLVSEGEYLKFDQPLTSNPNVGGFGQGDGEIVLQDPLRVQGLLFFLASVILAQIFLVLKKKQFEKVQLAEMNL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid thylakoid membrane; Single- pass membrane protein.
Protein: HAMB_BACCE
Sequence: MKLETAYNYFEKLEKDERLQNYISQANSRYILYIANEPLENFPHYTVNLDEKCTHIAFSYLNCGWRFFLEKISDEATKCMEKASEILEYLYAYSDCEKLYKEYYRLVCSLAYYISAQYSKSFIILGKYNSDSYIGKITKLFLTRNFIELERQLEIKYLKNDEETSSENKDNIIYEKILSNAFLHIINFIRTGKMESLESSKDMVRDLITLADINNEPHMWWYFRLLYLVFEEYEDGSLWKVVPPLLDNDDISAKYIYANLYKKKPITEFFKSQRECLDGELLKNDGFVIGMPTSSGKTKVAEVTILKTLTKSPGALCIYIAPYRSLANEVEFSLSSMFEIMGYQVSQLYGGSQTSPLDRQLTKQANVIIVTPEKAKSMLRSNKDLKDRIQLVIIDEGHLVGFQPRYITGELLIEELKIVLKKNNGQLVLLSAVLPNISDFSLWIGEDDKAKRMSVWRPSSQRFGELSLARNTVNINWEGETPSYNKNFITPKLVKPERITKTGRKYAAKYFPADKKEGVAATATKMLDVGSVLIYVGRSNMVLSQARIVSKLFEEKGIEHEWRNKNDWLFVELACIEEYGEDSEILSLLKQGIVPHSSKLPTEVRQSIEKLMANDNPKIIIATSTLGQGVNIGVSTVIVSNVRLDESNTVKVNDFWNIAGRAGRAFTDTEGKILYAIDRNKSQWSIYNQIQMKEMYFKYRNIEKATSGLYLLLRYLFILSEEFEIEYSLFLELLAENRESIDEQKAVEFFSEADQFLELLDDTLISMDIMNEANVLENSSSWIDDVFRSSLAFIQAKQDQSFSEEKMIEILKARNSGVIKLAGEETKWHSIASSSVPLRASLVIEHRIDELLKYVRKYIDSDKSFEELLSLVMELDIFIDSLPISKIEGIEIGANFSEIREGWFSGTSIHILEKRHENVRSICNEYYSFHFPWIVNAIAQKIKLIDCQEESKVLEQISLFAEIGLNNNKSVKIYLAGIKSRNCATELSEKIGMDNDLVTPVKELLLEFFNLCVVKKEDCSEICFNWLKLLNDEKEAKEYVKVKRRSFQFNIPFDLHDNLLYIKKVQSEIWLCSFDYKIKIPVLKEKALFNECSDIPDIFLRKEKGDVWILDSHNPYIIFY
What is the function of this protein?
Component of antiviral defense system Hachiman, composed of HamA and HamB.  Expression of Hachiman in B. subtilis (strain BEST7003) confers resistance to phages phi105, phi29, phi3T, rho14, SBSphiJ, SpBeta and SPR (PubMed:29371424).  Probably a helicase (Probable).
What are the official names of this protein?
Hachiman protein HamB, Probable helicase HamB.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
Protein: VG18_BPML5
Sequence: MWSRKDHMRIQSTLNGGFAEVSEEFAKQLIATGGWKVPRKPRNTKTKTAPEEPKNEE
What are the official names of this protein?
Gene 18 protein, Gp18.
Protein: NAG4_CANAL
Sequence: MSHATDSTLDNASVDSEKVRDFGDDLQNHPVQPTRSILSKIRSRDDDARSLVSNNKGVERIISDLQEGAGQLGPLEQPYDIKKIETHPDPHTDYNEADPWKYPIDSESGLRLVEWVDGDKHNPKNISKAKKWLYTLVLGAVCFVVALGSAIVTGDMERPAEYFGVSEEVIILASVTVFVIGFGVGPLVFAPMSEEVGRKPIYVVTLFIAVVFIVPCGAAKNIATLIVCRLIDGIAFSAPMTLIGGSLADIWEGPERGTAMAIFSAAPFLGPVCGPIFGGLLCDHAPTWRWIYWTFLIVAGVFYAIFIAIVPETHHGILLKKRAKKLRKETGDSRYRSFNELQIRSFGEVAKTSLLRPFVLLSELIVFLMTIYMAICYGLLYMFFFAYPVVYQQGKGWSASLTGVMFIPIGVGVIIATIAAPFFNKDYNRRAQVYRDRGELPPPELRLIPMMIACWFVPVGLFAFAWSSYTWVSWAGPCFSGLAAGFGFCCLYNPANNYIVDSYQHYAASALAAKTFVRSIWGACVPLFTIQMYHRLGDQWATSLMAFISLACCAIPYLFFFFGARVRTFSRYAYTPETNTK
What is the function of this protein?
MFS transporter involved in N-acetylglucosamine (GlcNAc) uptake (PubMed:19648376).  Confers resistance to cycloheximide, 4-nitroquinoline-N-oxide, and 1,10-phenanthroline, and contributes to virulence (PubMed:12076781, PubMed:12589826).
What are the official names of this protein?
Major facilitator superfamily multidrug transporter NAG4, N-acetylglucosamine utilization protein 4, Transmembrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAD_LYSSC
Sequence: MSEKIAVVPGSFDPVTFGHLDIIKRAADVFDIVYVAVLNNSAKNPLFSVEERMALMAEVTKALPNVRIESSSGLLIDYAKEKKAKAIVRGLRAVSDFEYEMQITSMNRFLDETIETFFIMTKNQYSFLSSSIVKEVAKYGSDVNELVPDCVVQALKEKYGFSQ
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_KLEP7
Sequence: MYQPDFPPVPFRLGLYPVVDSVAWIERLLEAGVRTLQLRIKDRRDSEVEDDVIAAIALGRRYHARLFINDYWQLAIKHQAYGVHLGQEDLETTDLSAIRQAGLRLGVSTHDDMEIDVALAARPSYIALGHVFPTQTKQMPSAPQGLEQLARHIQRLADYPTVAIGGISLEKAPGVLATGVGSIAVVSAITQAADWRAATDQLLALAGAGDE
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: AIM24_KOMPG
Sequence: MLTQRVCRILNANVTVRNLSIVQASSVSSEKRKDSEQPKLLSSIDDIGVNQASKPVFQVIGSPATVLNVSIPPSYPLYVSKGSIISLNSKDKHSVLDSLVSQTRLINPIKRTLFGLINFRYEKIFSTIPFNALVSSSVSTFSWGSSSKIVRQRSFVSLDLDGRLDWAVFPPKAVQAYAGDNLTITNPFLPKSLTKFPRVYTLISGRGLLSLTGEGQIYKITLGNETILIRKENLLAISVNGNSEIPQSLKNVNLNKELKEGSREQISSRPVLKYFSQAKDVITSSYRYLTGNNQYIKVHGPRTLLLSTNSQLESFHYKNGQGSENYFSLAKSIGFANPEPQPKDYLKVVTIEKGEIKGYESKNSFLEEQKQQAQ
What are the official names of this protein?
Altered inheritance of mitochondria protein 24, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM24 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TCMO_PETCR
Sequence: MMDFVLLEKALLGLFIATIVAITISKLRGKKLKLPPGPIPVPVFGNWLQVGDDLNQRNLVDYAKKFGDLFMLRMGQRNLVVVSSPELAKDVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYSEHWRKMRRIMTVPFFTNKVVQQYRFGWEDEAARVVEDVKANPEAATNGIVLRNRLQLLMYNNMYRIMFDRRFESVDDPLFLKLKALNGERSRLAQSFEYHFGDFIPILRPFLRGYLKLCQEIKDKRLKLFKDYFVDERKKLESIKSVDNNSLKCAIDHIIEAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELVNNPEIQKKLRHELDTVLGAGVQICEPDVQKLPYLQAVIKETLRYRMAIPLLVPHMNLHDAKLAGYDIPAESKILVNAWWLANNPAHWNKPDEFRPERFLEEESKVEANGNDFKYIPFGVGRRSCPGIILALPILGIVIGRLVQNFELLPPPGQSKIDTAEKGGQFSLQILKHSTIVCKPRSL
What is the function of this protein?
Catalyzes the first oxidative step of the phenylpropanoid pathway in higher plants by transforming trans-cinnamate into p-coumarate (By similarity).  The compounds formed by this pathway are essential components for lignification, pollination, and defense against ultraviolet light, predators and pathogens (By similarity).
What are the official names of this protein?
Trans-cinnamate 4-monooxygenase, Cinnamic acid 4-hydroxylase, C4H, CA4H, Cytochrome P450 73, Cytochrome P450C4H.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: BIOD_GLOVI
Sequence: MAGVLVSGTDTGAGKTILCAALAAWWLAHRRTPAAILKPVQCGPGDREYYRTVFGDALSVLNPLYFEAPLAPPLAAAREGQTVDIGLLWKSYCEAAAGHALVLVEGVGGLGCPLGWDYTVADLARDWRLPVLLVAPLRLGVVGQLVAHTGFARAQNLDLSALVLSEIEPVSAEQRAQWADVQLIENLCHLPVLGVLSHLEAATDRAALAAAGSGLWLEAAGTLFTAERG
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (By similarity).  This cyanobacterium does not encode bioA (which catalyzes the formation of the precursor for this reaction in the cannonical pathway), instead it encodes bioU, which replaces bioA and also performs the first half of the cannonical BioD reaction.  Thus in this organism BioD has a different substrate (By similarity).
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TREF_ECODH
Sequence: MLNQKIQNPNPDELMIEVDLCYELDPYELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSAKIFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRKFVENHFWLPEVYSSEYVSDPQNSLKEHIDQLWPVLTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLIPNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDTGRLASIRTTQFIPIDLNAFLFKLESAIANISALKGEKETEALFRQKASARRDAVNRYLWDDENGIYRDYDWRREQLALFSAAAIVPLYVGMANHEQADRLANAVRSRLLTPGGILASEYETGEQWDKPNGWAPLQWMAIQGFKMYGDDLLGDEIARSWLKTVNQFYLEQHKLIEKYHIADGVPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP
What is the function of this protein?
Hydrolyzes trehalose to glucose.  Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
What are the official names of this protein?
Cytoplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSTT_SALSV
Sequence: MATQRASGLLQRLAQGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPVLVLMLVMASIANHQHGQKTNIRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAQDIVPPSGIVEVLRGLLMSMVSNPIDALLNANYIGILVWAVSLGFALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAHLLVVLIGCMLLVALVVNPLLVFWKIRRNPYPLVFACLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGVPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGIPNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQAEDERLANNALRS
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TF3B_CANAL
Sequence: MSKPRKQQKCKTCGHTQFDVNRYTAAGDVSCLRCGTVLEENPIVSEVQFGESSSGAAMVQGAMVGADQARATFAGGRQNAMESREQTLSNGKRKIKRIAAALKIPDYIAEAAGEWFRLALTLNFVQGRRSNNVLATCLYVACRKERTHHMLIDFSSRLQISVYSLGATFLKMVKALHITSLPLADPSLFIQHFVEKLDFKDKATKVAKDAVKLAHRMAADWIHEGRRPAGIAGACVLLAARMNNFRRSHAEIVAVSHVGEETLQRRLNEFKKTKAGTLSVKSFREVENLESSNPPSFEKNRAMELKISKKLQQQQTDNFEDLSKMTEEEKQSVFGKLSKEEAQKQLLMNTILSDITITTENLNDQMDRILKMKKSSLENSLYKTPYELALANGSEQDPSKIWNINKPKNLVANLPKTDDILQNVSSEVELNSDDDDEIVLESKLTEEEVAIKERIWTGLNHDYLVEQEKKRLKQEADELTGNTSKSSSGNRRKRNKSSLPAELRKELGDIDLDEDGTPRSAADSAKMYISKTSVSKKINYDSLKGLLGGNMGF
What is the function of this protein?
General activator of RNA polymerase III transcription.  Interacts with TBP.  Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.
What are the official names of this protein?
Transcription factor IIIB 70 kDa subunit, TFIIIB, B-related factor 1, BRF-1.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAD_FINM2
Sequence: MNKTKVLYPGSFDPITNGHMDIIERSAKIFEEVNVAVVKNIQKKSTFTLEQRVEMIEKACKHLSNVKIHQFEGLTVDFAKQIGCSTIIRGLRAVSDFESEMQMSLANKKLNDELETLFLVADGKYAFLSSSIVREIASYGADISELVPENIVEDIKQRFNDK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_PYRHO
Sequence: MAKKGAGATRGISPVRPTRAIPIGAYLTVADNSGAKVIQVIGVVEYHGTRRRLASAGVGDMVVATVKKGRPDMRHQVVRAVIIRQRKEYRRLDGMRVKFEDNAAVIVTPEGVPRGTEIRGPVAREAAEKWVRIGSIASIIV
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: Y3883_DICDI
Sequence: MRDNNNNNEKYLIDFLKKVGSMRGSYSGSQIVIFASKDKKDEKIEKKRKIKNLKDKIRSQKRTIELEVENRRLRDRIDGLKSGINELTANLENLKKKSDNQKKDMSY
What are the official names of this protein?
Putative uncharacterized protein DDB_G0291422.
Protein: RNZ_PYRFU
Sequence: MIEVIFLGTGGIKPTPERNVPSIAIRIGSEIVLFDVGEGTLRQMEIAGLNPMRIKRIFITHFHGDHYLGLAAIIQTMNLWDRRETLHIYGPENSGEFISNFLKSGYFAPGFDVVVHEITGKARLQFENYEIWTFEVSHGIPALGYVFKEKDRRGNFDLEKIKSLGLTPGPWMKELEKRKIIKIGERVIRLSEVTGPKKRGAKVVYTGDTEPIDDIVEFSKRADLLIHEATYISSEHRKDSYHTTIEEAYEMFKSSKARHLALFHRAPRYSYQEYAVAAKELCPEAYVPRDFDRVFVGGMGNVIFKVR
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.  Shows also activity toward a broad range of substrates, such as intron containing pre-tRNAs, 5' extended precursors and non-RNA substrates.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: 5HT2B_HUMAN
Sequence: MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210).  Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538).  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538).  Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538).  Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity.  May play a role in the perception of pain (By similarity).  Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162).  Required for normal proliferation of embryonic cardiac myocytes and normal heart development.  Protects cardiomyocytes against apoptosis.  Plays a role in the adaptation of pulmonary arteries to chronic hypoxia.  Plays a role in vasoconstriction.  Required for normal osteoblast function and proliferation, and for maintaining normal bone density.  Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, Serotonin receptor 2B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Synapse, synaptosome.
Protein: MARCO_MESAU
Sequence: MGNKKALKEEAFLGSAEEGADFDQAMFPVMETFEINDPMPKKRNWGSFCTAVMAIHLILLTAGTTLLTLKVLSLQKWILEKYLDNETLAAEDRSFFSLQLASPETHLVPRTPGLQALQVQLTQVRTSQEQLLQQVDNLTRNPELFRIKGERGSPGIPGLQGPPGIKGEAGLQGPMGAPREPGATGAPGPQGEKGSKGDKGLIGPKGEHGTKGDKGDLGLPGSKGDMGMKGVTGVMGPPGAQGNKGDPGKPGLPGLAGSPGVKGDQGQPGLQGVPGTPGAAGPSGAKGEPGHPGPPGPTGPQGISGSPGAAGLKGSKGDTGIQGQKGTKGESGVPGLAGRKGDTGNPGLAGPKGEPGRPGLKGDPGMKGSSGQQGQKGEKGEKGQSFKEVRIVGGTNRGRAEIFYNNAWGTICDDNWDNNDATVFCRMLGYSSGKGFTFGGGSGNIWLDDVNCQGTEDSLWNCRKNNWGSHNCNHNEDAGVECR
What is the function of this protein?
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:10224290).  Also plays a role in binding of unopsonized particles by alveolar macrophages (PubMed:10224290).  Binds to the secretoglobin SCGB3A2 (By similarity).
What are the official names of this protein?
Macrophage receptor MARCO, Macrophage receptor with collagenous structure.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: MAN5_SALAG
Sequence: AGFYVDGNTLYDANGQPFVMRGINHGHAWYKDTASTAIPAIAEQGANTIRIVLSDGGQWEKDDIDTIREVIELAEQNKMVAVVEVHDATGRDSRSDLNRAVDYWIEMKDALIGKEDTVIINIANEWYGSWDGSAWADGYIDVIPKLRDAGLTHTLMVDAAGWGQYPQSIHDYGQDVFNADPLKNTMFSIHMYEYAGGDANTVRSNIDRVIDQDLALVIGEFGHRHTDGDVDEDTILSYSEETGTGWLAWSWKGNSTEWDYLDLSEDWAGQHLTDWGNRIVHGADGLQETSKPSTVFTDDNGGHPEPPT
What is the function of this protein?
Catalyzes the endo hydrolysis of beta-1,4-linked mannan, galactomannan and glucomannan.  It is able to hydrolyze mannosidic linkages that are flanked by mannose or glucose.
What are the official names of this protein?
Mannan endo-1,4-beta-mannosidase, Mannanase 5A, Man5A, Mannanase A, ManA.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
Protein: FMT_CORJK
Sequence: MKIVFAGTPEPAAVALEHLIADERIEVVAVVTQPDAKRGRGRSLRPSKVAEVAEEAAIPTYKWPSLKAGTESGDEARAVLGDLAAQGVTAAAVVAYGNLIPKDILDVFEHGWVNLHYSLLPRWRGAAPVQAALAAGDETTGASIFRIEEGLDTGPVAAQLTQKIGLEDTADDLLASLTYAGRELLADTLVAMDEGKAELSGQDDAQATHAPKIHPADAQIDWSQPAEVIQRVARAHTPAPGAWTLLDGQRYKIGMLLPSDPADVAELGPGEVVASPKKVFVGTGTGPLEITRIQPPGKKMMEAAAWARGQQELLAGRPTFSARETGE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: PYRB_ECOHS
Sequence: MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLDPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.