PharMolix/UniProtQA huggingface dataset:
Protein: WOR1_FUSO4
Sequence: MSGTMPLQPTFYGFIGDTTDALIIFEACLSGKLFHVPRRPHDRERQDLIKSGNIFVYEEHASGIKRWTDSISWSPSRILGNYLLYRELEKPFPPGEKKRARGRNGKSTTQSGGITKSRPRNSVPFQTGLEHGNEYTTVPSDDERHLVGSLVDSYDFKEQGLVKKTISITYQGVPHHLVSYYHVEDVKAGLLPSPVDDPRLRGVVPRTELLTGQNFRAPIEEAQHGTYLSGAYMPNMDHQYAPIGFPTHTQQPALQQQPQQQPQPQHQPQLQYQPQPHQHQPQLQYQPQQQHQPQQQYRPQPQHQPQLQYQPQALHPTAHGYPQSYGQTWW
What is the function of this protein?
Global transcriptional regulator of pathogenicity.  Acts as an activator of parasitic growth.  Not essential for colonization or penetration of the root surface, but required for expression of genes encoding effectors that are secreted during infection.  Involved in conidiogenesis, but is not required for conidial fitness, overall (colony) morphology, vegetative growth or carbon source utilization.
What are the official names of this protein?
Global transcription regulator sge1, Six gene expression protein 1.
What is the protein family that this protein belongs to?
Belongs to the MIT1/WOR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HOT_HUMAN
Sequence: MAAAARARVAYLLRQLQRAACQCPTHSHTYSQAPGLSPSGKTTDYAFEMAVSNIRYGAAVTKEVGMDLKNMGAKNVCLMTDKNLSKLPPVQVAMDSLVKNGIPFTVYDNVRVEPTDSSFMEAIEFAQKGAFDAYVAVGGGSTMDTCKAANLYASSPHSDFLDYVSAPIGKGKPVSVPLKPLIAVPTTSGTGSETTGVAIFDYEHLKVKIGITSRAIKPTLGLIDPLHTLHMPARVVANSGFDVLCHALESYTTLPYHLRSPCPSNPITRPAYQGSNPISDIWAIHALRIVAKYLKRAVRNPDDLEARSHMHLASAFAGIGFGNAGVHLCHGMSYPISGLVKMYKAKDYNVDHPLVPHGLSVVLTSPAVFTFTAQMFPERHLEMAEILGADTRTARIQDAGLVLADTLRKFLFDLDVDDGLAAVGYSKADIPALVKGTLPQERVTKLAPCPQSEEDLAALFEASMKLY
What is the function of this protein?
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG).  D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
What are the official names of this protein?
Hydroxyacid-oxoacid transhydrogenase, mitochondrial, HOT, Alcohol dehydrogenase iron-containing protein 1, ADHFe1, Fe-containing alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y172_TREPA
Sequence: MSDLEGLHLYNHSDEELFSIHDSVFQEHTGGEGRMSSSSGEEGCGQTLLPVHEKKSTYGLFNPLTGVGWRAYLEERLEAELGRATASEQDLTLMIVQVEHPAHQTAVADAAKKLVEFFKFRDMLFEFEGSCCFAGIVQDASLEERWYSRGIYTRSCAAPLRAHASLSASRRVRPD
What are the official names of this protein?
Uncharacterized protein TP_0172.
Protein: MTNN_SHEPC
Sequence: MKIGIIGAMEPEVAHLIAAMTNATSQTIAGIEFIAGTLAGKDVVVTRSGIGKVAASIATTLLIEKYAPDAVINTGSAGGFVDTLAIGDIVISSEVRHHDVDVTAFGYEIGQMAQQPAAFIPAAHLVEAANKAIAQLGEVKAIEGLICTGDSFICDPVRTQAMLKNFPTMAACEMEGAAIAQVCHQFGVPFVVIRSLSDNANNDSPVDFDSYIVKAGYHSALMVMLLLEQLK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: RS18_STRP7
Sequence: MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKILPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: BAGE5_HUMAN
Sequence: MAAGAVFLALSAQLLQARLMKEESPVVSWRLEPEDGTALCFIF
What is the function of this protein?
Unknown.  Candidate gene encoding tumor antigens.
What are the official names of this protein?
B melanoma antigen 5, Cancer/testis antigen 2.5, CT2.5.
What is the protein family that this protein belongs to?
Belongs to the BAGE family.
What are the subcellular locations of this protein?
Secreted.
Protein: BETA2_CHRSD
Sequence: MSQATEFDYIIIGAGSAGNVLATRLTEDSDVSVLLLEAGGPDYRFDFRTQMPAALAYPLQGKRYNWAFETDPEPHMDNRRMECGRGKGLGGSSLINGMCYIRGNALDYDHWAKQPGLEEWDYLSCLPYFKKSETRDIGPNDYHGGDGPVSVTTPKAGNNPLYRTFIEAGKQAGYPETEDVNGYQQEGFGPMDRFVTPKGRRASTARGYLDTAKQRSNLTIETRAVTDVIEFEGKRAVGVRYEQKGQPKQARARREVLLCGGAIASPQILQRSGVGNPEWLKELGIPVVHELPGVGENLQDHLEMYIQYECKEPISLYPALKWYNQPKIGAEWLFKGTGVGASNQFESCGFIRSRDDEEWPNLQYHFLPIAISYNGKSAVQAHGFQAHVGSMRSESRGRIRLTSKDPHAAPSILFNYMAKEKDWEEFRDAIRLTREIIAQPAFDRYRGREISPGPDVQSDEELDNFVKQHAETAYHPCGSCRMGEGDMAVTDAQGRVHGLEGLRVVDASLFPVIPTGNLNAPTIMLAEKIADRIRGREPLPRASVDYYVANGAPAKQAS
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: DTD_SALEP
Sequence: MIALIQRVTRASVTVEDEVTGEIGPGLLVLLGVEKEDDEQKANRLCERVLGYRIFSDADGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSGGAAPDRAQALYEYFVERCRQQAIDTQTGRFAADMQVELVNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESXN_MYCTO
Sequence: MTINYQFGDVDAHGAMIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA
What are the official names of this protein?
ESAT-6-like protein EsxN.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the ESX-5 / type VII secretion system (T7SS).
Protein: NOP5B_ARATH
Sequence: MVLVLYETAAGFALFKVKDEGKMANVEDLCKEFDTPDSARKMVKLKAFEKFDNTSEALEAVAKLLEGAPSKGLRKFLKANCQGETLAVADSKLGNVIKEKLKIDCIHNNAVMELLRGVRSQFTELISGLGDQDLAPMSLGLSHSLARYKLKFSSDKVDTMIIQAIGLLDDLDKELNTYAMRVREWYGWHFPELAKIISDNILYAKSVKLMGNRVNAAKLDFSEILADEIEADLKDAAVISMGTEVSDLDLLHIRELCDQVLSLSEYRAQLYDYLKSRMNTIAPNLTALVGELVGARLISHGGSLLNLSKQPGSTVQILGAEKALFRALKTKHATPKYGLIFHASLVGQAAPKHKGKISRSLAAKTVLAIRVDALGDSQDNTMGLENRAKLEARLRNLEGKDLGRLSGSSKGKPKIEVYNKDKKMGSGGLITPAKTYNTAADSLLGETSAKSEEPSKKKDKKKKKKVEEEKPEEEEPSEKKKKKKAEAETEAVVEVAKEEKKKNKKKRKHEEEETTETPAKKKDKKEKKKKSKD
What is the function of this protein?
Required for 60S ribosomal subunit biogenesis.
What are the official names of this protein?
Probable nucleolar protein 5-2, MAR-binding NOP56/58 homolog 2, Nucleolar protein 58-2.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: YL121_MIMIV
Sequence: MSLRSYMIYDEYNRKYISLYNYRTSFFSQQEKSLFDKIKSEIVSDDDFVIYGTDCKKYFLDYCILKNDLNVLDTLVLKYPWHAVIFDHSVSDFLVNSDGLVNIHQYILNFISANKIDHYEDILNYLLSHNIDISGHDNIAIMIAVQRKNLSMVKKLVEYGADIHANNDRALKLAVDDIEMFQYIVDMGADIHIDNDYCIRAATLIFNFDLLQFLVELGCDINIGNGYLLRTIINADFYYHRTITKNNVFEIVKYINVNSLGPHELTNCIHVHKNIELIKLLSDYGADFTFINKFCVMNEYEENVVDILKNHGLKYESILKFVLKYQSFMH
What are the official names of this protein?
Putative ankyrin repeat protein L121.
Protein: NEUI_TAKRU
Sequence: MTGTAISVCLLFLLSVCSACYISNCPIGGKRSIMDAPQRKCMSCGPGDRGRCFGPGICCGESFGCLMGSPESARCAEENYLLTPCQAGGRPCGSEGGLCASSGLCCDAESCTMDQSCLSEEEGDERGSLFDGSDSGDVILKLLRLAGLTSPHQTH
What is the function of this protein?
Isotocin causes contraction of smooth muscles.
What are the official names of this protein?
Isotocin-neurophysin IT 1.
What is the protein family that this protein belongs to?
Belongs to the vasopressin/oxytocin family.
Protein: PTH_EHRRW
Sequence: MLHLLVGLGNPGKEYELTRHNVGFMIIDAIMHHFLFPDFKKKHNALISSGSIRSHKVILAKPYTFMNNSGTPISSIVKLYKIPLDNIIVFHDETDIDFCTIRIKKGGGNAGHNGLKSIDTLLGRDYWRIRFGIGHPSNGYDLSYHVLSQFNNLNAVNNTISNIIEHISLLFENDKSIFKNKVKDLIKYTDISS
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYSRL_PSEAB
Sequence: MDKLTAMATFVKVVDAGSFTRAADALGLPKARVSQRVSDLEKHLGVRLLNRTTRALSLTHDGSAYFDKCQVLLQQIDELEATLRGGTATPIGRLRVDSLITIARWVIAPRLHDFQARYPRIQLRLSSSDRISNLLEDGIDCTIRGGALKDSSMIARHLCDIQMGLYASPEYLASIGGVDSPNDLSQFRRLSWFSGRERNPFMWELESGPERFVVQSGDGMQFDEPDVAISACMAGSGICPGAPFAVAGFVRAGKLVPVLPQWHFSAAPVHVIYPGSRHLSVRVRCFVNWVMELFAENPEIQLTPIALALESGLAQRT
What is the function of this protein?
Represses the transcription of the operon that consists of PA14_22510 to PA14_22540.
What are the official names of this protein?
HTH-type transcriptional repressor PA14_22550.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: PNP_CAUVC
Sequence: MFDIKRKTIEWGGKTLVLETGRIARQADGAVLATMGETVVLATAVFAKSQKPGQDFFPLTVNYQEKTFAAGKIPGGFFKREGRPSEKETLVSRLIDRPIRPLFVKGFKNEVQVVVTVLQHDLENDPDILGMVAASAALCLSGAPFMGPIGAARVGWVDGAYVLNPTLDEMKESKMDLVVAGTADAVMMVESEIQELSEEIVLGGVNFAHQQMQAVIDAIIDLAEHAAKEPFAFEPEDTDAIKAKMKDLVGADIAAAYKIQKKQDRYEAVGAAKKKAIAALGLSDENPTGYDPLKLGAIFKELEADVVRRGILDTGLRIDGRDVKTVRPILGEVGILPRTHGSALFTRGETQAIVVATLGTGDDEQFIDALEGTYKESFLLHYNFPPYSVGETGRMGSPGRREIGHGKLAWRALRPMLPTKEDFPYTIRLVSEITESNGSSSMATVCGSSLAMMDAGVPLVRPVSGIAMGLILEQDGFAVLSDILGDEDHLGDMDFKVAGTSEGLTSLQMDIKIAGITPAIMEQALAQAKEGRAHILGEMNKAMDAPRADVGDFAPKIETINIPTDKIREVIGSGGKVIREIVATTGAKVDINDDGVVKVSASDGAKIKAAIDWIKSITDEAEVGKIYDGKVVKVVDFGAFVNFFGAKDGLVHVSQISNERVAKPSDVLKEGQMVKVKLLGFDDRGKTKLSMKVVDQETGEDLSKKEAAAEEA
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNC5B_HUMAN
Sequence: MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIVKNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTLSDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSLKVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRDPGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDTPVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKASPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC
What is the function of this protein?
Receptor for netrin required for axon guidance.  Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.  Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity).  Functions as netrin receptor that negatively regulates vascular branching during angiogenesis.  Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity).  It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906).  Mediates apoptosis by activating DAPK1.  In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
What are the official names of this protein?
Netrin receptor UNC5B, Protein unc-5 homolog 2, Protein unc-5 homolog B, p53-regulated receptor for death and life protein 1, p53RDL1.
What is the protein family that this protein belongs to?
Belongs to the unc-5 family.
Protein: MATK_PINPT
Sequence: MDEFHRCGKEDSFWQQCFLYPLFFQEDLYAISHDHYLDVSSSSRPMEHLSSNDQLSFLTVKRLIGQIRQQNHSIVLFVNCDPNPLADRKKSFYSESVLEALTLVLEVPFSIWSKYSVEGMNESKSFRSIHSIFPFLEDKFPHSNSILDARIPYSIHPEILVRTFRRWIRDAPSLHPLRSVLYEYRNSPDNLQRSIIVVPRVNTRFFLFLWNYYVCECESILFSRLKRSSHSRSLTHGSFPQRTHFHRKIKHIIIFSRRNSLKSIWSLKDPKIHYVRYGERPIIAIKGAHLLVKKCRYYLLIFRQFYFHLWSEPYRVCSHQLSKNCSSSPGYFLRVRMNPILVRTKMLDELFIADLITDEIDPIVPIVPIIGLLATEKFCDISGRPISKLSWTSLTDDDILDRFDQIWRNLFHYYSGSFDRDGLYRIKYILSLSCAKTLACKHKSTIRVVRKELGPELFKKSFSKEREFYSLRFSSKAAARSQRERIWHSDISQINPLANSWQKIQDLKIENLFDQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PTH_COLP3
Sequence: MTIKLIAGLGNPGPEYSKTRHNAGVWFVEELARSHNISLRPEKKYSGLYGKGLIAGNLVHLLIPTTFMNRSGQAVAPLANFYKISVDEILVAHDELDMLPGVCKIKKGGGHGGHNGLRDIIDRMANNKDFYRLRIGIDHPGHRDKVTGHVLGKAPSAEQAKIEQAIDEASRCLDIWLKDDLKKAQNRLHSFKAE
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_SHESW
Sequence: MAKLTKRMRVIREKVDGTKLYEINDAVALLKELATAKFVESVDVAVNLGIDPRKSDQNVRGATVLPHGTGRDVRVAVFTQGANAEAAKAAGAELVGMDDLAEQIKAGEMNFDVVIASPDAMRVVGMLGQILGPRGLMPNPKTGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFTPVQLKENLEALISALKKAKPAVAKGVYVKKVSISTTMGAGVAVDQATLDTAN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: MSBA_BLOFL
Sequence: MHYCNNGNISNWKVFRRLWPIINPFKIGLIIASITLIINAVSDSLMLALLKPLLDEGFGKANRSIFMWMPLVLMGLMIMRGMSGFASTYCISWVSGKVVMHIRRLLFNHIMNMPVSFFIEQSTATLMSRITYDADQVASSSSGALITIIREGASVVGLCIMMFYYSWQLSLVLILIMPIISIIIKLVSNKFKDIGKKIQNSMSQLVNSVEQMLKGHKEVLIFGGQHLEQNRFNYLSNRMRQYTMKMVQTSSVFEPLIQFVASLALACVLYIASIPSVIEMLSAGTITVIFSSMIALMKPLKSLTNVSAQFQRGMVACQTLFTILDLKTEKNIGKFSVKRVKGHIIFDNVTFFYPETNTPSLCNINFNIESGKTIALVGRSGSGKSTIVNLLTRFYDVYQGRILLDGLNLNDYTLTSLREQVSVVTQNVYLFNDTIANNIAYARTRFYSRASIEEAAKMAYAMGFISKMKNGFDTIVGENGILLSNGQRQRIAIARALLRNCPILILDEATSSLDTESECIIYKSINILKKNRTSLIIAHRLSTIENADEILVVERGSIVERGIHVDLLNHKGVYSQLYKFQFS
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CRP1_YEAST
Sequence: MSSELMFNYTFSWPAGPKDVILTGTFDDWRGTLPLVKTAKGNFEITMPVKLANKDDTFQFKFIVDGVWCVSDSYKKEHVSEGIENNFLQITDLVETQEVAGASRIPEAGGLLCGKPPRSAGPPSTSNRKKNKRNNKKRRSKLKKKSTKNNKKSNESLDDNEEEDGVTGTTTEDVTGTSREETPLAEPTNVSKEAPGNFHILPIDQSADTTQSNGIIGGPGPVLVPNPGEIKEFTEIRDVDARELNERLNKKEEVPEPVAGPIVESSVTEKSPALPQADDPIVETKEVAHNVQELTPQVEAVTPLINEPEPLPTPEAQISIPESSKVEPVEGSLQSKLVEKRESTEGVLDGSKKVENKAKKDEEVFTLDPIVNKAPKLPLTDEQTAEGRKSPAVSEEKEKKKKQEKGSKEVKRSETSKEKKPSAKEVKKQTVKAPKKQTASPLSSSTEEPKKKKTGFFGKLKKLFK
What is the function of this protein?
Cruciform DNA-binding protein which exerts an enhancing effect on the cleavage of cruciform DNA (X-DNA) by endonuclease VII from bacteriophage T4.
What are the official names of this protein?
Cruciform DNA-recognizing protein 1.
What is the protein family that this protein belongs to?
Belongs to the CRP1/MDG1 family.
Protein: TATA_CUPNH
Sequence: MGSFSIWHWLIVLVIVMLVFGTKKLRNIGQDLGGAVKGFKDGMKDGEGKAAADPAQSKELRDSTTIDVEAKEKTRQQ
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MSR21_ORYSJ
Sequence: MSDSNPGAANPALGPDADAAAGEGLELAQFAAGCFWSVELTYQRLPGVARTEVGYSQGHRHEPTYRDVCGGGTGHAEVVRVHYDPKACPYEVLLDVFWAKHNPTTLNRQGNDVGTQYRSGIYYYTAEQEKAARDSLAEKQKEWKERIVTEILPATRFYPAEEYHQRYLEKGGQSAKKSCNDPIRCYG
What is the function of this protein?
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins.  Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation.  MSRA family specifically reduces the MetSO S-enantiomer (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase A2-1, OsMSRA2.1, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase, Protein-methionine-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MAF1_BOVIN
Sequence: MKLLENSSFEAINSQLTVETGDAHIIGRIESYSCKMAGDDKHMFKQFCQEGQPHVLEALSPPQTSGLSPSRLSKSQGGEDEGPLSDKCSRKTLFYLIATLNESFRPDYDFSTARSHEFSREPSLSWVVNAVNCSLFSAVREDFKALKPQLWNAVDEEICLAECDIYSYNPDLDSDPFGEDGSLWSFNYFFYNKRLKRIVFFSCRSISGSTYTPSEAGNELDMELGEEDEEEEEESGGGGSEGGPEEPGTMEEDRVPVICM
What is the function of this protein?
Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity).  Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity).  Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB.  When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription.  Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout.  Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity).
What are the official names of this protein?
Repressor of RNA polymerase III transcription MAF1 homolog.
What is the protein family that this protein belongs to?
Belongs to the MAF1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ECHA_HUMAN
Sequence: MVACRAIGILSRFSAFRILRSRGYICRNFTGSSALLTRTHINYGVKGDVAVVRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLAACKTLQEVTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPGLKPPEERTIEYLEEVAITFAKGLADKKISPKRDKGLVEKLTAYAMTIPFVRQQVYKKVEEKVRKQTKGLYPAPLKIIDVVKTGIEQGSDAGYLCESQKFGELVMTKESKALMGLYHGQVLCKKNKFGAPQKDVKHLAILGAGLMGAGIAQVSVDKGLKTILKDATLTALDRGQQQVFKGLNDKVKKKALTSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTSALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVAEDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILASLKLPPKSEVSSDEDIQFRLVTRFVNEAVMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKIVDRLKKYEAAYGKQFTPCQLLADHANSPNKKFYQ
What is the function of this protein?
Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:8135828, PubMed:1550553, PubMed:29915090, PubMed:30850536).  The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090).  Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536).  Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed:8135828, PubMed:29915090, PubMed:30850536).  Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity (PubMed:23152787).  It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP (PubMed:23152787).  Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity (PubMed:23152787).
What are the official names of this protein?
Trifunctional enzyme subunit alpha, mitochondrial, 78 kDa gastrin-binding protein, Monolysocardiolipin acyltransferase, TP-alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Protein stability and association with mitochondrion inner membrane do not require HADHB.