PharMolix/UniProtQA huggingface dataset:
Protein: PSTA2_MYCTO
Sequence: MGESAESGSRQLPAMSPPRRSVAYRRKIVDALWWAACVCCLAVVITPTLWMLIGVVSRAVPVFHWSVLVQDSQGNGGGLRNAIIGTAVLAIGVILVGGTVSVLTGIYLSEFATGKTRSILRGAYEVLSGIPSIVLGYVGYLALVVYFDWGFSLAAGVLVLSVMSIPYIAKATESALAQVPTSYREAAEALGLPAGWALRKIVLKTAMPGIVTGMLVALALAIGETAPLLYTAGWSNSPPTGQLTDSPVGYLTYPIWTFYNQPSKSAQDLSYDAALLLIVFLLLLIFIGRLINWLSRRRWDV
What is the function of this protein?
Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Phosphate transport system permease protein PstA 2.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPF_ACAM1
Sequence: MTSIRIGNGYDIHQLVEGRPLILGGVQIEHSLGLKGHSDADVLTHAIMDALLGALSLGDIGHYFPPTDPKWAGADSLKLLEQVHQLILDRGWQIGNIDSVVVAERPKLKPHIEAMRDRISQVLNLSPELIGIKATTNEKLGPVGQEQGICSYAVALLTSDS
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: ECC1B_MYCSE
Sequence: MSTEAEPRVLREVVLSQLATGESRAYKMWLPPLTDPTPVNELVERDYQRRPLRFGLGIMDEPRRHRQEVWGVDVSAAGGNIAVGGAPQTGKSTFLQTLVVSAAATHTPRQVQFYCVDLGGGGLMYLEDLPHVGGVATRAEPDRVNRVVAEVKAVLRAREQVFKQYRVGSIASYREMRDDPSNPASQDPFGDVFLVIDGWPAFVAEFPDLEPAVQDIAGQGLAYGVHVIITTPRWTELKSRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSLEKHHLMMGVPRLDGVHSADNIVEAISSAVQQIAGRHTDQAPQVRVLPERIYLHQLDPNPPGPDSDYRTRWQVPLGVRESDLTVAYNQMHLTPHLLIFGAPKSGKTRIAHAVAQAICKRNSPQQVRFMLADYRSGLLDAVPQSHLLDAGAINRNSATLEEAIKALAVNLKKRLPPPDLTTAQLRARSWWSGPDVVLLVDDWHMVTAAAGMVSPMAPLGPLLPAAADIGLHVIVTCQMSMAHRATMDKFVGAAYGAGSPTLFLSGEKNDFPSRDIIVKKRPPGQAFLVGPDGKEVIQAAYVDPPEEEVFSPPSEGS
What is the function of this protein?
Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (PubMed:18554329).  Plays a role in DNA conjugation, in both donor and recipient strains (PubMed:18554329).
What are the official names of this protein?
ESX-1 secretion system protein EccCb1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CG050_MOUSE
Sequence: MAKHKRKGLEGTGKESKRQKITPAEETPRTSEAGPDKETASTLVQEASPELSPEERRVLERKLKKERKKEEKKRLREAGIAATQTAKVQTLPAKPSAATLALEYLQGWAQKQESWRFQKTRQTWLLLHMYDEDKVPDEHFPTLLDYLEGLRGSARELTVRKAEALMQKLDEAEPEDSGGSPGKVQRLRQVLQLLS
What are the official names of this protein?
Uncharacterized protein C7orf50 homolog.
Protein: RL16_LEVBA
Sequence: MLVPKRVKFRRVHRGKLRGEAKGGKSVAFGDYGLQALDSHWISNRQIEAARVAITRYMKRGGKVWIKIFPHKSYTAKGVGVRMGNGKGTPDGWVAPVKRGKVMFEVGGVSEEVAREALRLAAMKLPVRTKVLSREEVGGESNED
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: NFI_AERPE
Sequence: MNRREVRCAFSASKAARAQLLLRGKVRLEPLPTRPRTVLGLDASYSAKDGVGVGAAVLISLETLEPVDCRVYISRVCIPYIPGLLAFRELAVMAPAAAALSAEADVVMVDGHGIAHPRRFGIASHVGVILERPSIGVAKKKLVGTLVEGPGGMYVVQDGERLAIVLGTRPREVYVSPGHRITLEEAASIARATIRPGGWMPEPTRLADVISKALKTIIGGQSLINSALASLCRVKLGPRLEELERPLRRAGLEVE
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EQXG_FUSHE
Sequence: MATTDPAIAAPDDSQLEAGRENIRANVGDALEKPSSSTGTMVDEPTDPNVVDWDGPHDPEHPLNWSKTQKNLHLVIVSLFTLAANLAATMFAPGAEELATEFSITNSTVTAMTVSLYVLGFALGPLLLAPLSELYGRLVIYYGCNFVYVVFTIGCAFSTNVAMFLVFRIICGCAASGPMSIGGGTVADLFPQEERGKAMALFTVGPLLGPSGLIGVATVIFMRETNYMVLLQRKAQRARKETGNDKLVPKLTRNETPKQMLARAIVRPLKLLIFSPIVLLISLYTGILFGLIFLLFTTFPSVFQDVYGFSPGTAGLAYLGLGIGMILGLVLFSVLSDKMLKQKSGAARPEDRLILMKWLGPITPLGLFIYGWTAKYAVHWIVPIIGTFVVGFGSLFVVIPGQIYLVDAFGAEAAASAMAANLLVRSPFGAFLDLTASPLYVSLGLGWGNSVLGFICLLFTPVPWLFYTYGERMRTHFKVDL
What is the function of this protein?
Efflux pump that might be required for efficient secretion of equisetin or other secondary metabolies produced by the equisetin gene cluster (PubMed:23614392).
What are the official names of this protein?
MFS transporter eqxG, Equisetin biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KCY_BURMA
Sequence: MKSTRPFHPTPVITIDGPTASGKGTVAALVAAHLGFHLLDSGALYRLAALASIRYQVEPDDADALASLVDGLHITFREGCAQLDGVDVSDEIRAEAVGNRASAIAVHASVRAALVARQRAFRKTPGLVADGRDMGTLIFPDAVLKVFLTASVEARAARRHKQLMQKGFSANIDNLLQDLRERDARDSNRAAAPLKPAADAKPLDTSALTIEQSVEQVLAWYRELGQPA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_METNO
Sequence: MFAVIKTGGKQYRVAANDVITIAKLEGEAGTAVTFGEVLLYADGEGATQVGAPTVSGISVAGEIVAQKRGPKIIAFKKRRRQNSRRKRGHRQDFTVVRVTGISAA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: BETB_RHIEC
Sequence: MKAQPKASHFINGEYVEDTDGTVIESLYPATGEVIARLHAATPAIVEKAIAAAKRAQPEWAAMSPMARGRILKRAADIMRERNRELSELETLDTGKPIQETIVADPTSGADAFEFFGGVAPAGLNGSHIPLGQDFAYTKRVPLGVCVGIGAWNYPQQIACWKGAPALISGNAMVFKPSENTPLGALKIAEILHEAGLPKGLFNVIQGDRDTGPLLVNHPDVAKVSLTGSVPTGRRVAAAAAGSLKHVTMELGGKSPLIVFDDADLDSAVGGAMLGNFYSTGQVCSNGTRVFVQKAVKAEFLKRLKARTEAMLIGDPLDEATQIGPMVSWAQREKVIAYIEKGKAEGATLVAGGGIPNNVSGEGYYVQPTVFADVTDDMTIAREEIFGPVMSVLDFDDEDEVITRANASEFGLSGGVFTADLSRAHRVVDRLEAGTLWINTYNLCPVEIPFGGSKQSGFGRENSLAALEHYSELKTVYVGMGPVAAPY
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: HISZ_SYNSC
Sequence: MALQPAAGAKDLNPRQVETNRQLTERLASVYRLWGYDEVSPPRVERLATLMAGGAIDSSDIVRLVADDPLGLRPEMTASIARAACTRFADRQRPLRLWASGTVFRTRSADEGGQCIEENLQSGVELFGVSGSEAEMELLSLLMASVQTLGLQTSQKPRLLLGHTALMDLVLRPFNGAVRDQIRTALIDFDRLAIESFDLAYAEKTRLLSLMDCRGTPDQVLAQLSSLYGEQPVFDELRRLCTHLASAAQAQAVTIQLDPTFQPHFELYTGLVFQLVCDGRSSPVVFARGGRYDDLVRRCGATDDRAFGAGFSLAIDPIRELISDLDAAEQQQSDVLIAFSTASNLESAMERQRSWHEQGRTAVMALEPLSSMQEAELQAKAQGGLQLDWVDP
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2696_GEOSW
Sequence: MKVTYHGHSVVKIETNGKTIFIDPFITGNGATDLKLEDVKADVILLTHGHGDHVGDTVQLAKKNNALVIAPFELATYLGWQGVNTHPMHIGGAHQFDFGKVKLTQAFHGSGYVTEDKQIIYLGMPAGILFTAEGKTIYHAGDTGLFSDMKLIGERNSIDVAFLPIGDNFTMGPEDAAVAAEWLRAKIVVPIHYNTFPVIAQDPHQFVALLPDGVGRVLKPGEGIEL
What are the official names of this protein?
UPF0173 metal-dependent hydrolase GWCH70_2696.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: DAPE_VARPS
Sequence: MSRTLQLAEQLISRPSVTPDDAGCQQILGERLARLGFTLETIESGPADFRVTNLWAVRRPAGTAPTKTLVFAGHTDVVPTGPVEQWTSHPFTPTHRGGKLYGRGACDMKTSVAAFVVSIEEFLAATPDPRLTLALLLTSDEEGPGVDGTVIVCNALAARGETIDYCIVGEPTAVERCGDMIKNGRRGTMSGKLTVHGVQGHIAYPHLAKNPVHAVAPALAELVAINAAGGWDAGNAYFQPTSWQISNFHAGTGASNVIPGSAVIDFNFRFSTESTPESLQKRVHAVLDAHGVDCTLAWTIGGLPFLTTPGELVSAVQAAIADETGIATELSTSGGTSDARFIAKICKQVVELGPVNASIHKIDEHIDVAEIETLKNIYKRTLERLEASLIQ
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: CYB_ANTLE
Sequence: MINLRKTHPLMKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLAEWIWGGFAVDKATLTRFFAFHFILPFIIVALAIVHLLFLHETGSNNPTGINPDSDKIPFHPYYTIKDALGLMFLFLILLLLALFSPDSLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIMPFLHTANQRSMMFRPVSQTLFWILTANLITLTWIGGQPVEQPFIIIGQLASMLYFLLILVLMPLAGLFENYMLKPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VP6_BTV17
Sequence: MLLAPGDVIKRSSEELKQRQIQINLVDWAESEGGKEDKTEPKEESKAEGSKDGEGTQSESGQKEEGGKETKDADVDRRIHTAVGSGSSTKGLGERANENADRGDGKVGGGGGDADAGVGATGTNGRRWVVLTEEIARAIESKYGTKIDVYRDEVPAQIIEVERSLQKELGISREGVAEQTERLRDLRRKEKNGTHAKAVERGGRKQRKKTHGDAQREGVEEEKTSEEPARIGITIEGVMSQKKLLSMIGGVERKMAPIGARESAVMLVSNSIKDVMRATAYFTAPTGDPHWKEVAREASKKKNILAYTSTGGDAKTEFLHLIDHL
What is the function of this protein?
Surrounds and interacts with the genomic dsRNA.  Possesses ss- and dsRNA-binding capacity.  Its hydrophilic nature and capability to bind ss- and dsRNA suggest that it interacts with BTV genomic RNA.
What are the official names of this protein?
Protein VP6, Minor inner core protein VP6.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Inner capsid.
Protein: UREE_RALSO
Sequence: MLSIDKHLPAPHGLAAVLVRRAPKLVLPFLARSRSRLRATLDDGREVAVVLPRGTVMRGGDVLVAEDGTLVEVQAAPEQVLRVTSDSRLALMRAAYHLGNRHTPVQVVADALQLEADPVLEDMLVRLGVTVTHVQAPFEPEAGAYGGGHRHGHDATFEEDYAAAQALYREHHGHSHDRGCDHSHSHSHDHDHDHGHVHGPGCGHAPHHRHD
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOB_STRPC
Sequence: MSKFNRIHLVVLDSVGIGAAPDADKFFNAGVADTDSDTLGHISETAGLSVPNMAKIGLGNISRPIPLKTIPTEDNPTGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQMETGELIVYTSADPVLQIAAHEDIIPVEELYKICEYARSITLERPALLGRIIARPYVGEPGNFTRTANRHDYAVSPFQDTVLNKLADAGVPTYAVGKINDIFNGSGITNDMGHNKSNSHGIDTLIKTLQLPEFTKGFSFTNLVDFDANFGHRRDPEGYRDCLHEFDNRLPEIFANMKEDDLLLITADHGNDPTYAGTDHTREYIPLLAYSASFTGNGLIPQGHFADISATVAENFGVDTAMIGESFLGHLK
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BICL2_HUMAN
Sequence: MSSPDGPSFPSGPLSGGASPSGDEGFFPFVLERRDSFLGGGPGPEEPEDLALQLQQKEKDLLLAAELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSLRLGPGPAGGFLSNLFRRT
What are the official names of this protein?
BICD family-like cargo adapter 2, Bicaudal D-related protein 2, BICD-related protein 2, BICDR-2, Coiled-coil domain-containing protein 64B.
What is the protein family that this protein belongs to?
Belongs to the BICDR family.
Protein: HSLV_SALDC
Sequence: MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELGAREIAEKALDIAGDICIYTNHFHTIEELTAKA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV, Heat shock protein HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_CHRSD
Sequence: MAEDNNQAAQGGNDAQNQLQFSMQRIYVKDISFESPNAPSVFQNAFKPKVGLDLNTTHKQVGENLYEVVVKVTAQVTNNEDGATAFLAEVEQAGLFRIAGLSDDQLDHTLGAFCPNMLFPYARECIDNLVNRGSFPPLMLSPVNFEGMYAQKKKRESEAAENAH
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDRA_DEIDV
Sequence: MKLSDVQKRLQAPFPAHAVAWKPGVITKDRSRALMLAHIDARNVQDRLDAVCPDAWSFEVEVVPGTRLPTVKGRLTVLGVSREDIGEAPEGDLGTLKAAASDALKRCAVQFGIGRYLYDLPKQWVAWNDAKREPVSPPELPEWARPDHERSPGGAHLVQAMDQLRYEMPEDLELQREVYKHLKAALGSLHPISGGNQGRAA
What is the function of this protein?
ssDNA-binding protein that contributes to the ionizing radiation resistance of D. deserti.  Plays a role in DNA repair and genome reconstitution, in a RecA-independent process, since DdrA is essential for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation in an environment lacking nutrients (Probable).  In vitro, binds to the 3'-ends of single-stranded DNA, and probably protects them from nuclease degradation.  Thus, DdrA is part of a DNA end-protection system that helps to preserve genome integrity following irradiation or desiccation.
What are the official names of this protein?
Single-stranded DNA-binding protein DdrA, DNA damage response protein A.
What is the protein family that this protein belongs to?
Belongs to the RAD52 family.
Protein: RLMC_SHIF8
Sequence: MQCALYDAGRCRSCQWITQPIPEQLSAKTADLKNLLADFPVEEWCAPVSGPEQGFRNKAKMVVSGSVEKTLLGMLHRDGTPEDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSDTKLAQLRKALPWLHEQLPQLKVITVNIQPVHMAIMEGETEIYLTEQQALAERFNDVPLWIRPQSFFQTNPAVASQLYATARDWVRQLPVKHMWDLFCGVGGFGLHCATPDMQLTGIEIAPEAIACAKQSAAELGLTRLQFQALDSTQFATAQGEVPELVLVNPPRRGIGKPLCDYLSTMAPRFIIYSSCNAQTMAKDIRELPGYRIERVQLFDMFPHTAHYEVLTLLVKQ
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: CA12_CONLE
Sequence: MGMRMMFTVFLLVVLATTVVSFTSDRAFDGRNAAASDKASDLISLAVRGCCSHPACSVNNPYFCGGKR
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
What are the official names of this protein?
Alpha-conotoxin-like Lp1.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL25_NOSP7
Sequence: MTITVESLKRPEGSKPRALRRSGLIPANLYGHKGTESISLTIEAKTVERLLKRVSVNNTLIELNIADAPWRGKALLRELQIHPAKGTPYHLSFFAVAGHGDTTVEVRLRFVGTAVGVKQEGGVLDTVITELQVSCAPENIPDVIEIDVTNLQIGDSLSISDIPFPEGVTPLAELERLVVSVLPPQISADDAGTETETAS
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: PKP2_DANRE
Sequence: MLKPHPEHKEQPQDSFTPSGDSTPDASMAEERDFMRSVLPVYDSFHPEDSSLALPLANKLTLADAHRLNRLQQQVQLTLSRKKRKPKPADSSLAESQSSCQISSSSSLGSLHLKRTFSVNHEATRSLRMVDRSQWPSMEPPLFHRGYGSFRYTPKRAGLCLGSNSLTLPSAPTTSHFQMNKLPLRYAHSEVLRNPRFAGLSAATQIPSSPVYENPHTDDTDDVFLPSTSVERGRMESEKHTLQQTLCKQREGGFVALEQSENVSWQSRVRKPSLEFVAGRRPSQTGSLISMEEQSGSLGRIEKLEVKQHAVTTLTKKGKPGELSAEMTLKEAVNLLTQDNNMETQIAAANFIQNQCFNSPDAKRKILHLQGIPKLLKLMQNDSEELQWAAVSSLRNIVFENNENKMEVKDCEGLPVILRLLKINRDIETRRQLTGLLWNLSSHDLLKEHLSREAVKPLTDSVLVPCSGISEGEDPKLELLADPDIFYNATGCLRNLSSAGPDGRKVMRDCEGLIECVIYYIRGTIADYKPDDKATENCVCILHNLSYRFDCEVPRVDSPVAQKPKQTHTETSNPGCFIIKTPKNSAENLEADEDYPALEENGSPHGVEWLWSAITVRMYLSLIAVSTNQHTKQASIGTLQNLTACSGEISQAIAHFIVQKEGGLSQVKKLLQEAEKEELRISVSLLKNISRYRELHADIVKQVLPELVAILPNSDRNVEQPIEITVTICHILINLSQASASNTCAIINQGALPKIISISSKDNGFGPTRAGQAACVLLHTLWRHSELHSSFKKAGYRKTDFINNRTVKAVNSARE
What is the function of this protein?
Required for development of the heart, potentially via cell-cell adhesion and modulation of expression of cardiac precursor genes (PubMed:23124967).  Plays a role in desmosome cell-cell junctions and their intracellular connectivity (PubMed:23124967).
What are the official names of this protein?
Plakophilin-2.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
Protein: RS13_MYCPU
Sequence: MARILNIEIPSNKRVVISLTYILGIGKSLSKEIIVKANEKLAKAKEKTFTEDSRVKDLSEEQLQAIRDSAKTYLTEGDLRREVSLNIKRLMEIKCYRGIRHRKGLPVRGQVTQKNARTRKGPRKTVAGKKGK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PERM1_MOUSE
Sequence: MDNFQYSVQLSDREWAEFSATADECGLLQADLASGDEPLSSDIDQGDSSGSSPPGPPPLFTGQLVSQGRGQQSRELEDVAAQQLVSRSQCEPVLALEASHQVAGTSTQSEAPLFPSLDSVCPGQALSFPGPATCRDKMQRLLQGPAPSSPSKAPHSPESPGHSDNPQSSPDSLEASPRNPGRKKRRAVGAKGTKHSGSLDSAATQMSSPQLTRPKEALMSGTLMAKAQQDKPQPDSTSPEQMAREESGLDLSTPILITEQDQIRKTSRAALHVVSKPVQEVHPDVPMASPNVSTRASKPQPDVALPKPASKPQSDIASSTHPFTPDVSLSTLAFKCQPNTNQSTPASEPDMALSTPASEPDTALSTPASEPDTALSTPASEPDTALSTPASRSQLVKAEFASACTPGLHVDLSAAGSEIKPEVSSSMPAAVDVLRTDLPRSVSKTESKESVSIPVKPSLSPISQAEAAMVDTGVSVPPGGSIEKPAGQFSAGSSGESCLGPVQAPKKKKVRFSMAIPSHEDSGSGEPTGSPFLTPEQPPVPRTAAGSRGGSAAWDAVAVAPRLPQPRILKHLPPPVSSVSAEAESGNCFAVTLPEAYEFFFCDTIEEEDEDVEDEEAASQALDEVQWPDTCEFFFRDSRAQRSRCQRGHSPVSPPRADTVAPVPPEGLVPISIPEVYEHFFTEEGFGHRQPAATPMQTSELSREGGLEASTKPVSPTAEHLSLTVRKAGELRSPLTSFTFSQNDMCLVFVAFATWAVRTSDLQAPDAWKTVLLANIGTISAIRYFRRQVGRGHSGRPRSSSSSNPSC
What is the function of this protein?
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity.  Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A.  Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.
What are the official names of this protein?
PGC-1 and ERR-induced regulator in muscle protein 1, PPARGC1 and ESRR-induced regulator in muscle 1, Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shows a nuclear localization in the presence of PPARGC1A.
Protein: NTPPA_HYPNA
Sequence: MPGSAPLILASASPRRLELLAQIGIVPDRVAPTDIDETRRKAESPRELALRLAREKAAACDAEGAFVLAADTVVALGQRNLEKAADETEAADFLRLLSGRAHQCITGVAVRAPSGQIVSRAVLARVKMKRLTEAEIAAYVASGDWKGKAGGYGIQGAAGGFVTAINGSYTAIVGLPLYETKSLLEGLGYRR
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_DESAL
Sequence: MKQELIDFLCKKSVNFSDEPSFKLVSGRLSRFYVNCKPTILHPRGMYLVGHLVMEAVKEAKLDGIGGLTFGADPVAMAAAFASELMGCPIKAFSIRKEPKDHGIIKWVEGDMQEGERVAVVDDVVTTGGSTIKAIERARSQGLEVAKAVILVDRQEGGLENVAKLVPDASAIVTRAELLEAWNKLKK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ATPE_HISS2
Sequence: MATFKLIVVSAEQHIFNGEVKGIQATGSEGELGILAGHLPLLTAIKPGIIKITLEDDTEEVIYISGGFLEVQPTIVTVLADVAIRGKELDRERILEAKRKAEQNIVSGAKDASYEMLVSKLSRELAKLRAYELTDRLTQRKR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.