PharMolix/UniProtQA huggingface dataset:
Protein: RIPA_COREF
Sequence: MNNARLLWCHSGVVNVCLGEQTFTLVAGDLLYAPEGAFWSDTGSGLILELRFRILGIDGPARRIHLGRAWAERMVHEYSRSLFGEDAVSGDVAKLFADRVPTPPLPAPRHARAVAQTLAANPADQTSLEEFAAQRGVSARTLQRQFLSSTGYSFSEWRAAQRVCVATSLLAHDFSIAVVANLVGFSATSSLTRAFRRHIGTTPSAFTTGGIGMGVAGTPAAIPSRTTFAAATRDQQLWIYTGTATVTTPGYCRFLTQGDMATIPAGTHTRIDVAAGSIAIPVPIGVGEQGMSLQEVATLRDQEPSTGLMLVEESRWVHLGRELLPATAPVSL
What is the function of this protein?
Under iron limitation, represses the acn (aconitase), catA (catechol 1,2 dioxygenase), leuCD (isopropylmalate dehydratase), narKGHJI (nitrite/nitrate transporter and nitrate reductase), sdhCAB (succinate dehydrogenase), pta (phosphotransacetylase) and katA (catalase) genes.
What are the official names of this protein?
HTH-type transcriptional regulator RipA, Repressor of iron proteins A, RIPA.
Protein: NPIB4_HUMAN
Sequence: MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKVINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLRSICMHTKKRVSSFRGNKIVLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPSADDKLKTPPECLLTPLPPSALPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRYLLSVCGFRFHHQPMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSLPEPKRRRLS
What are the official names of this protein?
Nuclear pore complex-interacting protein family member B4.
What is the protein family that this protein belongs to?
Belongs to the NPIP family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TCAF_XENLA
Sequence: MKVLEDYRSLVHGIGSLDFSGDAVPCKLLLTGDTAFPVLVTPRKDVLIAASRYGKGKVVVMAHESYLNTNAFMDFLKNAVSWLSPNSEANIGVHKGLNLLTDNLSANGSKVQNTSTLIEGLGVFCTIGYDDSQDKQIISFVREGGGLLIGAQAWHWSYSHKQENVLHHFPGNKIISVSGVHFTSDYGEKGNICVMENIPQAPIYTSFDFSLDQKYLLKGMSQLDISGSSIPSDLLLHGTLSFPVGLSENKQCFLGATYYGKGRVVVATHEGYLSKSELKTIMLNAISWLDINQNRRIGVHKGLRQFAELLQKENIPCNISSLDPDLSVYCCTSYSDAEAKAIHEFVAEGGGLLIAGHAWYWSSQNSDLDVLIQYPGNKILNKFGISILDRTIPGGNYNAINPDESSQQYHFRRGLCNLQAELRSGAEVKPPLSIWMNKLRQDVTAFMRLPANPIISSIQSQFVEMMQICEIPNVTKQCPVSSCSKEAFILCLAQECFNVCDESHILEKEPSITVEIDGTNPGNNAWRSTGLYLAPRKTAVLEFPASAVHQGLQVQVGCQSDDLSSADKYCRAPVVVRRFHVDSQRVSVSCFWGGLVYITVKANSNLGIIPVKVYEAEPAPIYIKGKTSLDTWIQSIRNLPAPWAELITENIILTVPSDAIRSLSDPEALLSLWDKIMVAITELAAIPKKLPRPERFVADVQISAGWMHAGYPIMCHLESAKELTDLNIMQTGGIWGPIHELGHNQQKTNWELPPHTTEATCNLWSVYVHETVLGIPRSQAHCCLQAETRANHIQEYLRNGSNIEQWNVWTALETYLQLQEGFGWEPFKQLFKDYQSMSGIRNENKSKMNLWAEKFSEAVQTNLVPFFEAWGWPIEEATHSKLSVLPVWEKDPMKSYLSARKSNSN
What is the function of this protein?
May play a role in the regulation of the cation channel TRPM8 activity.
What are the official names of this protein?
TRPM8 channel-associated factor homolog, TRPM8 channel-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the TCAF family.
Protein: STB3_ASHGO
Sequence: MASVLLLPHQRRKHRQKRARTASYRKPMSQGSSPSPAMEVDGPEFPGKTGGQTIAEMGEERSGAGTGNTGTGGQSSVSGAGGKAGALNTAKLVLSHKPISTSSPEAMAAAQQVTPQKLAQLLLAKGPLAIRFITQALTEEIPSFKDLSASKQRRLIMGALEAGDQENSVVFAKIGWGQWSARHVKPHLFIKERELTNVANSKVKDAGVHEARRSSSNAKKGGKSGSFLNELKRPMLAAPTASIYIDENALASDDDEEDDEEDEHDMLNYENLKRRQPSVVAVEPPELSDQQEVLFRARLRAPNGGSRRRSTSKVRSVSVSKPGAHRAPPAAGDAVEGPLRRLSPSQADRKSTIDIATPEEPPHDELLSANSVAKTRRAAARRDSWLSRSKESSIRSTLLSHSNYNIVSPPSHAQPPADHHPLGREADHSDTDEEDWASIGAPALRNNSMPSNLSSSSSHHGNSASASNAHSEQGSPHARPLNYAIPNSIPPRQHSPPDAEDAAFLLMSLKS
What are the official names of this protein?
Protein STB3.
What is the protein family that this protein belongs to?
Belongs to the STB3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y286_METMP
Sequence: MLKELINKLLWHPDYNPEDYIINYLHRGAENDEKSVPLKNIVIEDSFLVFDETHIPFHRILEIVNTKTGEIIYKKR
What are the official names of this protein?
UPF0248 protein MMP0286.
What is the protein family that this protein belongs to?
Belongs to the UPF0248 family.
Protein: YR643_MIMIV
Sequence: MWVNDINIMSYQAMARNYINGKWRHAPNRADPCGVCRPVPLLCPVNGGACDPMGPCGLAASSKCSPQCGPCSPNFPYPTGPGGTTICDFAAAACGGATGNVCNMCPGGSCGGIGGCYGANSPCGLNGTIGCGGCGSGCCGSQVGTGFHLARGSCDPNYVSGCSSPCGTCRPPNAPSTLCDLALLGISPVPLGMPVSQSVTTLGIPPGAVPPPPPVPITGGVPPFGGPSCGPTVFGGGSFGGSCGGSCGGSCGGGSCGGGSCGGKSGKKDCCKSCRKGKKCKCKKKKCCGVEQFSVCTDGPSIQIGGPCAPPPPPIPPIPGVGVSYDTQVGPAIPLNQCDYPWAEYWPWVVGSWAGQYTNEM
What are the official names of this protein?
Uncharacterized protein R643.
Protein: GLNE_YERPY
Sequence: MLPLPSELQIQAQSIKQRFSELPVPPDLRDEDIAVLALSDFVSDMLLIHPQWLEELHQQPPQPQEWQYYSQWLSQALAGVQDEAALLTALRLFRRRVMVRIAWSQVLQTSGTAETLQQLSTLAESMIIAARDWLYQVCCRELGTPCNRQGVPQPLLILGMGKLGGGELNFSSDIDLIFAYPENGQTQGGRRELDNAQFFTRLGQRLIKALDQHTIDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGGADDPYSQELRQMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFITQVFQLIRGGREPRLQERALLPTLQAVAELGLLPEQQVADLSGSYLFLRRLENLLQAIADEQTQTLPNDPLNQARLAWGMGYADWAAMSTALENHMQAVRVVFDDLIGDETPDIGEDPSHGLYKSLWQDVLEESDLAPLTPHLEEAARRQLLATISGFRHDVDKRTIGPRGREVLDQLMPRLFAEVCPRPDANVALSRLILLLLSIVTRTTYLELLVEYHAALKHVIRLCSASPMVASQLARYPLLLDELLDPQSLYQPLAPSAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQQLRIAAGDITEALPVMKVSDHLTYLAEAIIDAVIQQAWNQMVARYGQPSHLQQSEGRGFAVIGYGKLGGWELGYSSDLDLVFLLDCPLDVMTDGDRSIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGEAGMLVSTIEAFADYQRNEAWTWEHQALVRARIVYGSPKLHQQFDAIRQQILCRHREDPQLQQEVREMREKMRNHLGSKQRDIFDIKADAGGITDIEFIAQYLVLRYAASEPRLTRWSDNVRIFESMAHYDIMSPEEAAALTRAYVTMRDEIHHLALQEQSSKVAADSFIAEREQVAASWHKWLAANDANVS
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: JZ67B_CHIGU
Sequence: MRVLLIIAGLALLSVVCYTSEMKEQNSLNEVLSAFFDVEEPQEKGCIICF
What are the official names of this protein?
U37-theraphotoxin-Cg1a, U37-TRTX-Cg1a, Jingzhaotoxin-like peptide JZTX-67.2, JZTX-67.2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 67 (Jztx-67) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: XTH2_ARATH
Sequence: MNRIRYCFELVSVLFLMFTANARARGRGAIDFDVNYVVTWGQDHILKLNQGKEVQLSMDYSSGSGFESKSHYGSGFFQMRIKLPPRDSAGVVTAFYLTSKGDTHDEVDFEFLGNRQGKPIAIQTNVFSNGQGGREQKFVPWFDPTTSFHTYGILWNPYQIVFYVDKVPIRVFKNIKKSGVNYPSKPMQLVASLWNGENWATSGGKEKINWAYAPFKAQYQGFSDHGCHVNGQSNNANVCGSTRYWWNTRTYSQLSANEQKVMENVRAKYMTYDYCSDRPRYPVPPSECRWNQ
What is the function of this protein?
May catalyze xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET).  Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
What are the official names of this protein?
Xyloglucan endotransglucosylase/hydrolase protein 2, At-XTH2, XTH-2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted, extracellular space, apoplast.
Protein: GLND_ECOHS
Sequence: MNTLPEQYANTALPTLPGQPQNPCVWPRDELTVGGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVRNSAITGIYSTTLRQLRHARRHLQQPLCNIPEARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSTELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: PRI2_MOUSE
Sequence: MQFSGRIRKKLRLAGDQRNASYPHSLQFYLQPPTENISLTEFENLAFDRVKLLKAIENLGVSYVKGTEQYQSKLEAEIRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEDLRRWFIQQEMDLLRFRFSILPKDKVQSFLKDSHLHFEAISDEEKTLREQDIMASSPSLSGIKLESESVYKVPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRATLSKALALTARSLPAVQSDERLQPLLNHLSHSYTGQDYSTQKNTGKISLDQIDSLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIRGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCMKIILTNPPGQGDYHGCPFRHSDAELLKQKMQSYKIPASGISQILDLVKGNHYQVACQKYFEMTHNVDDCGFSLNHPNQFFFESQRILTGGKDIKKEISQPETPQHKPSTQKTRDAASALASLDSSLEMDLEGLEEYF
What is the function of this protein?
Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:8026492, PubMed:8253737).  During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity).  The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:8253737).  These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity).  In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:8253737).  Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch.
What are the official names of this protein?
DNA primase large subunit, DNA primase 58 kDa subunit, p58.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase large subunit family.
Protein: RS15_SYNY3
Sequence: MSLTQIRKQELMTEYQAHETDTGSADLQVAFLTERITQLTGHLKANPKDHASRRGLLKMIGRRKRLLSFINAREPERYQALIKRLGIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: NUOI_RHIL3
Sequence: MASLSGSISSLFLKEFVGAFFLSMRYFFRQKATINYPFEKGPVSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYFDKARLLDNGDRWEREIARNIAIDSPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL11_STAAW
Sequence: MAKKVDKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTQDQAGLIIPVEISVYEDRSFTFITKTPPAPVLLKKAAGIEKGSGEPNKTKVATVTKDQVREIANSKMQDLNAADEEAAMRIIEGTARSMGIVVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SCHA_STRHA
Sequence: MTVSAAVSTVPDRVPLTVFDGSRVRVVLMLDIRDGTQAEVLDAYERMSDRVAAVPGHISDQLCQSLENPTQWLITSEWESAPEFLAWANSEEHLEMVRPLEPYVRGTHSMRYSVLRETAEERAGAGAAARGALQPRPRIGDNVVRHAVTYTVKPDSVTEVVKILSAYTSPEVRVDDTTRLVRTSLFLYGNRVVRAIEVRGDLQAALRHVARQPEVRAVEEALTPHIEQDRDLTDPRSARLFFTRAALPAVHHVVSGRGTGGDTQRCALYYPAHPGAGPALARLLARQGEATVGDPGSPVVACTVFHRDDLVVRLVDTAGAPERAPGAVLALHEPDALAEAGRLLDAAALGADGPPDDRALPTFLAHARMRPLTDRQSPAS
What are the official names of this protein?
Protein SchA.
What is the protein family that this protein belongs to?
Belongs to the SchA/CurD family.
Protein: PDEF_ECOLI
Sequence: MKLNATYIKIRDKWWGLPLFLPSLILPIFAHINTFAHISSGEVFLFYLPLALMISMMMFFSWAALPGIALGIFVRKYAELGFYETLSLTANFIIIIILCWGGYRVFTPRRNNVSHGDTRLISQRIFWQIVFPATLFLILFQFAAFVGLLASRENLVGVMPFNLGTLINYQALLVGNLIGVPLCYFIIRVVRNPFYLRSYYSQLKQQVDAKVTKKEFALWLLALGALLLLLCMPLNEKSTIFSTNYTLSLLLPLMMWGAMRYGYKLISLLWAVVLMISIHSYQNYIPIYPGYTTQLTITSSSYLVFSFIVNYMAVLATRQRAVVRRIQRLAYVDPVVHLPNVRALNRALRDAPWSALCYLRIPGMEMLVKNYGIMLRIQYKQKLSHWLSPLLEPGEDVYQLSGNDLALRLNTESHQERITALDSHLKQFRFFWDGMPMQPQIGVSYCYVRSPVNHIYLLLGELNTVAELSIVTNAPENMQRRGAMYLQRELKDKVAMMNRLQQALEHNHFFLMAQPITGMRGDVYHEILLRMKGENDELISPDSFLPVAHEFGLSSSIDMWVIEHTLQFMAENRAKMPAHRFAINLSPTSVCQARFPVEVSQLLAKYQIEAWQLIFEVTESNALTNVKQAQITLQHLQELGCQIAIDDFGTGYASYARLKNVNADLLKIDGSFIRNIVSNSLDYQIVASICHLARMKKMLVVAEYVENEEIREAVLSLGIDYMQGYLIGKPQPLIDTLNEIEPIRESA
What is the function of this protein?
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.  Truncated proteins consisting of the GGDEF/EAL domains (residues 319-747) or of the EAL domain alone (481-747) have c-di-GMP phosphodiesterase activity.  They do not have diguanylate cyclase activity.  Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.
What are the official names of this protein?
Cyclic di-GMP phosphodiesterase PdeF.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR7_RICTY
Sequence: MKKKLYEGSSKILYSAEEDFLLIMAFSDKAVLETGETVDISGKGVLNNSISSFLMGKLEMIGIENHLIEKINMREQLIQYVEVFPIQVIISSVACGRFVKEFGMDEGYVFDKPIIDFKVRSREFNYPIVNEYQIFNFGWLTMDEIRTVQAQTLRIYDFLSGLFIGIGIRLVECKLEFGRVFNGEESIIMLTDEISPDNCRLWHINSNEKLGFELIENEPNKAFESYQLIANRLKEK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: KTHY_LEUCK
Sequence: MTRPLFITFEGPEGAGKTSVLEALVSELKPILGDQLVTTREPGGNPISEAIRQILQPEDDNGMDDRTEALLYAAARRQHIVETILPALSAGKVLISDRYVDSSLAYQGGGRDLGVDNIWQINQFAIDGLLPDLTIYFDVPSELGLSRVMANRQGKIDRLDKESLSFHQRVRTTYLELQHDFSDRIKIIDATQPLTDVISDTRALLQEALNSRKG
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RPO11_METKA
Sequence: MKLPEVEVVVKKYDKDEVLLELPGEDHTLCNLLRWALNRQDGIIATYRIEHPILGKEHKVDEERYVPPKMRIRAVDEDADAREALERAIEELLELVEEAKEEFSGALEEKES
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit L.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_MARSD
Sequence: MISSKGKYFFTSESVTEGHPDKVADQISDSILDAILAQDKDARVACETLVTTGMAFIAGEISTTGYADFQQIVRDTIREIGYVHSDMGFDADTCAVISSIDKQSVDIAQGVDRNTPESQGAGDQGMMFGFACKETEALMPAPIYYAHKLSRKLTEVRKDATLDYLRPDGKTEVAFEYLDGKPVRIADVVIAAQHDDGIEQGQIYEDIKREVVLASLPAEMIDDATKIYINTTGRFVIGGPMGDCGLTGRKIINDTYGGMGNHGGGAFSGKDPSKVDRSGAYMARYIAKNIVAAGLAERAEVQVAYAIGVAEPVSVLATSHGTGEVSDETLTKAVKEVFDLRPWYISERLDLRRPIYKPSACYGHFGRNNPNFTWERTDAVDDLRTACKI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSME_MYCTU
Sequence: MVAMLFYVDTLPDTGAVAVVDGDEGFHAATVRRIRPGEQLVLGDGVGRLARCVVEQAGRGGLRARVLRRWSVPPVRPPVTVVQALPKSERSELAIELATEAGADAFLAWQAARCVANWDGARVDKGLRRWRAVVRSAARQSRRARIPPVDGVLSTPMLVQRVREEVAAGAAVLVLHEEATERIVDIAAAQAGSLMLVVGPEGGIAPDELAALTDAGAVAVRLGPTVLRTSTAAAVALGAVGVLTSRWDASASDCEYCDVTRR
What is the function of this protein?
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA.  Acts on the fully assembled 30S ribosomal subunit (By similarity).
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase E, 16S rRNA m3U1498 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RsmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSB11_MOUSE
Sequence: MQGGEPASVMKVSESEGKLEGLATAVTPNKNSGNSSCGGAISSSSSNSSRGGSAKGWQYSDHMESVNGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSGNSPISQRRPSQNAMSFFNVGHSKLQSVNKRAHLHPDHLVEVREMMSHAEGQQRDLIRRIECLPASGLLSSLDQDLLMLKATSMATMNCLNDCFHILQLQHASHQKGALPSGTTIEWLEPKIPLSNHYKNGAEQPFATEPNKPMGAPEAQCVAESGVLAREPEDISADDEVEDTCDNKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIGITNGATPEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFHCSWRMPKSEVASGVSSSSSTPAITDHAPLPEEAPTQSVSDCYTVRFVAEQVSHHPPVSGFYAECAERKMCVNAHVWTKSKFLGMSIGVTMVGEGVLCLLEHGEEYTFSLPCAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVTAEVKYNLTNTVVCRVQGEWNSVLEFTYSNGETKFVDLAKLAVTKKRVRPLEKQDPFESRRLWKNVTDSLRESEIDKATEHKRSLEERQRTEERLRTETGTPWKTKYFIKEGDGWVYHKPLWKGIPSQPAE
What is the function of this protein?
Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage.  Weakly binds 25-hydroxycholesterol.
What are the official names of this protein?
Oxysterol-binding protein-related protein 11, ORP-11, OSBP-related protein 11.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
What are the subcellular locations of this protein?
Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Note=Localizes at the Golgi-late endosome interface.
Protein: Y547_MYCTO
Sequence: MPEETQVHVVRHGEVHNPTGILYGRLPGFHLSATGAAQAAAVADALADRDIVAVIASPLQRAQETAAPIAARHDLAVETDPDLIESANFFXGRRVGPGDGAWRDPRVWWQLRNPFTPSWGEPYVDIAARMTTAVDKARVRGAGHEVVCVSHQLPVWTLRLYLTGKRLWHDPRRRDCALASVTSLIYDGDRLVDVVYSQPAAL
What are the official names of this protein?
Uncharacterized protein MT0547.
Protein: YRB3_CAEEL
Sequence: MHSQFGKHKSDISLLTPAPPSPKAFGLLYAAHWLGSTDPEIWERLETLANENQCLIDLRDEKVPGTYETQLFVIGYAGNIVTVLKQLQDYIDEPNNFDRFDIDRRPRKETLKMCVPTDMFLSKFGVGLVAEGRITHYEQNRGVTIKTYAISQSQHVISVYSNENNHQLPLHDLVEYFAYPSQCYEKSFAQKIPYLVDNKSGLLNRFKDISKLDVIKTPRDQLWLMALDGMKTVDARESILQALRENPDSASLYVRACKLEHLPSCKMEWLLHALQRDTLDDKMKIIKHAETYFRGPAILQILESAVLSLSNDIHIVRELAIAHEKSGNFEKSMQFLKDCIDNNSWNSTELTASMIHCEHAGANRTSKVYLEAMYSIFNFTTSEEAALIEIVKVLVETDSPLSAKSLSLELMTRYAGTPTFEKTRQLFHSLFYTTCSKSDSERYDDTFIKHMAKWNKKQQEQQK
What are the official names of this protein?
Uncharacterized protein F58F12.3.
Protein: VATG3_HUMAN
Sequence: MTSQSQGIHQLLQAEKRAKDKLEEAKKRKGKRLKQAKEEAMVEIDQYRMQRDKEFRLKQSKIMGSQNNLSDEIEEQTLGKIQELNGHYNKYMESVMNQLLSMVCDMKPEIHVNYRATN
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons.  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
What are the official names of this protein?
V-type proton ATPase subunit G 3, V-ATPase subunit G 3, V-ATPase 13 kDa subunit 3, Vacuolar proton pump subunit G 3.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase G subunit family.
Protein: RL2_OPITP
Sequence: MAIHSFRPLTPAGRFTSLNKREGLSKKRPQKALTEPKPKTGGRNVYGRITTRHIGGGHKQLYRIIDFKRDILDMPATVEALEYDPNRTSNLALVVYANGEKKYILAPEGLQVGAKIFASNKATTNDYNVGNNFPLHLIPPSTRVHAVELVPGRGAKIARAAGTGLELVAVEGDRATLKMPSGELRLVNAKCRATIGEVGNGDHNNQSLGKAGRRRWLGVRPTVRGMVMNPVDHPNGGGQGKSKGGGGRQQLVSPWGQLAKGFPTRRRSKQSNAQIIVHHNGRKPRGKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.