PharMolix/UniProtQA huggingface dataset:
Protein: NUP60_YEAST
Sequence: MHRKSLRRASATVPSAPYRKQIISNAHNKPSLFSKIKTFFTQKDSARVSPRNNVANKQPRNESFNRRISSMPGGYFHSEISPDSTVNRSVVVSAVGEARNDIENKEEEYDETHETNISNAKLANFFSKKGNEPLSEIEIEGVMSLLQKSSKSMITSEGEQKSAEGNNIDQSLILKESGSTPISISNAPTFNPKYDTSNASMNTTLGSIGSRKYSFNYSSLPSPYKTTVYRYSAAKKIPDTYTANTSAQSIASAKSVRSGVSKSAPSKKISNTAAALVSLLDENDSKKNNAASELANPYSSYVSQIRKHKRVSPNAAPRQEISEEETTVKPLFQNVPEQGEEPMKQLNATKISPSAPSKDSFTKYKPARSSSLRSNVVVAETSPEKKDGGDKPPSSAFNFSFNTSRNVEPTENAYKSENAPSASSKEFNFTNLQAKPLVGKPKTELTKGDSTPVQPDLSVTPQKSSSKGFVFNSVQKKSRSNLSQENDNEGKHISASIDNDFSEEKAEEFDFNVPVVSKQLGNGLVDENKVEAFKSLYTF
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).
What are the official names of this protein?
Nucleoporin NUP60, Nuclear pore protein NUP60.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Nuclear basket.
Protein: GLUA2_ORYSJ
Sequence: MASINRPIVFFTVCLFLLCDGSLAQQLLGQSTSQWQSSRRGSPRGCRFDRLQAFEPIRSVRSQAGTTEFFDVSNELFQCTGVSVVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPETYQQQFQQSGQAQLTESQSQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVTDINNGANQLDPRQRDFLLAGNKRNPQAYRREVEEWSQNIFSGFSTELLSEAFGISNQVARQLQCQNDQRGEIVRVERGLSLLQPYASLQEQEQGQMQSREHYQEGGYQQSQYGSGCPNGLDETFCTMRVRQNIDNPNRADTYNPRAGRVTNLNSQNFPILNLVQMSAVKVNLYQNALLSPFWNINAHSIVYITQGRAQVQVVNNNGKTVFNGELRRGQLLIVPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPTDVLANAYRISREEAQRLKHNRGDEFGAFTPLQYKSYQDVYNVAESS
What is the function of this protein?
Seed storage protein.
What are the official names of this protein?
Glutelin type-A 2, Glutelin type II.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
Protein: TIG_BURCM
Sequence: MANVVENLGKLERRVTISLPKDTVQKEIDARIQKLAKNVRMPGFRPGKVPLKMVAQQYSGQVEAEVLSDKIGQEFFTISRAENLRVAGQPSFEPKQEQAEDAYAFDATFEVYPEVKIGDLATAEVERSTTSIGDAEIDRTLDILRKQRVHYHARGEAGEHGDGGADTAAKDGDRVTVDFVGKIDDVAFQGGTAEDFPFVLGEGRMLPEFETAALGLKVGEQRTFDLKFPDDYHGKDVAGKTAQFTVTMKKIEWPHLPEIDAEFAKSLGIEDGDLTKMRAEIKENLEREAKRRTQSIVKNQVMDALLKISELDVPKALIEQDQQRLVEMARQDLAQRGVPNAKDAPIPAEMFAEQAERRVKLGLVLAELVKANGLEAKPEQIRAEVDEFAKSYEDPKEVVRWYYSNQQRLAEMEAFVVESNVVDFVLGKAKVTDKEVSFEALASASSQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RISB_HELPG
Sequence: MQIIEGKLQLQGNERVAILTSRFNHIITDRLKEGAMDCFKRHGGDEKLLDIVLVPGAYELPLILDKLLESEKYDGVCVLGAIIRGGTPHFDYVSAEATKGIASAMLKYSMPVSFGVLTTDNIEQAIERAGSKAGNKGFEAMSTLIELLSLCQTLKG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: PERR_STAAB
Sequence: MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK
What is the function of this protein?
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins.  May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
What are the official names of this protein?
Peroxide-responsive repressor PerR.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKGS_ECOLI
Sequence: MRMIGLLYDFKDYASKMAENMARLAALLHYFSGDGGDISVTG
What are the official names of this protein?
Protein YkgS.
Protein: OBG_SALPB
Sequence: MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAIAEALGWEGKYYLISAASQLGVKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LADH_METVS
Sequence: MFIDGKWILREDLDILNPYTLEIIERITALDREETKYAIEVATENKDVMKELNPSKRYSLLMKIAEHISSKKDLFANTISVDVGKPIKQSRIEVDRTITAFRLSALYAKELRGETIPSENEIIFTKKEPVGVVGAITPFNFPLNLITHKIGPAIATGNAVVLHPSSKAPITAIYLTKVIEHVLKKMNIERGVFNLTTGNGEIVGDEIAKNEKINFLSFTGSVEVGELISKSSYMKKVALELGGNNPLIVLKDSDIELAAKSAVKSKFLNSGQVCISVGKVIVEEEVLETFTKKVIEETKKLVLGNPLDEKTDLGPLITPESALRVEILIKESISEGGELLIGGNRSNSLISPAVLNIDEDNILSKVEAFGPILPILKAKDDEHALNIANNSKYGLQAGIFTNDINKAMKFANKLEYGGVIVNGSPTFRKDNMPFGGIKKSGLGKEGIKYAVEEMCETKTVVIHNM
What is the function of this protein?
Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.
What are the official names of this protein?
Lactaldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: ATPA_DICNV
Sequence: MQLNASEISSFIKDKIADYDNKVENKAEGTIVNVSDGIVQIQGLSQAMLGEMIELPNGNFALAMNLERDSVGAVVLGAYEHLREGDKVHCTGRILEVPVGRGLLGRVVDALGNPIDGKGKIDAEGSSPVEKIAPGVIERQSVDQPLQTGLKAIDSMVPLGRGQRELIIGDRQTGKTAIAIDAIINQKNTGVICIYVAIGQKASSIASVVRKLEEADALKHTIVVAASASTSAAMQYIAPYSGCAMGEFFRDRGEDALIIYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARINAKEVERLTAGKVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNSGIRPAINAGLSVSRVGGAAQTQIIKKLGGGIRLALAQYRELAAFAQFASDLDEATRKQLEHGQRVTELMKQKQYAPLSVAEMAISLFAADKGYLDTVAVEDIMAYETALLSFMRENHADLMNTINTTGKYDEAVQTGLKEALDAFVEKRSL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MURE_PROMM
Sequence: MTQMLHSLLRAVGLPVPEGLANPSLAMVSCDSRSVAQGCLFLGLPGEQVDGGSFWRQALAAGAEAAVIGPAAAALQPPGPTDAVVVVPEPVAAWVGQLAAAFWQQPSSRFALIGVTGTNGKTTTTHLIEHLSVAVGRSTALFGTLVNRWPNYSVPATHTTAFADRLQAQLAQAVEAGAELGVMEVSSHALEQQRVAGCRFAGAVFTNLTQDHLDYHCSMEAYFEAKAQLFAPPLLESGSAKAVVNIDSPWGARLAQRLGDTCWRSSLAEGVLQQADAELKMTELTMSSDGVQGRLISPCGEGWFDSPLMGRFNLMNLLQAVGVLLQQGLPLPLLLKAIADFRGVPGRMERVLIPAADATQVPTVLVDYAHTPDGLENALKASRPFTSKNLCCVFGCGGDRDRGKRSQMAAIAARLADRVVVTSDNPRTEDPQQILADVVAGIPEGTTCTVEVDRAVAIALAIAEAAPGDVVLVAGKGHEDYQILGTSKVHFDDREEAERALKQRLDG
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADA_VIBPA
Sequence: MTNQTRNVVVVDCLRTPMGRSKGGAFRHTRAEDLSAHLMKGILARNPQVNPSEIEDIYWGCVQQTLEQGFNIARNAALLAGLPIEIGAVTVNRLCGSSMQALHDGTRAIMTGDAEICLIGGVEHMGHVPMNHGVDFHPGMSKNVAKAAGMMGLTAEMLGKLHGISREQQDEFAARSHARAHAATLEGRFKNEILPTEGHAADGTLFQLDYDEVIRPETTVEGLSQLRPVFDPANGTVTAGTSSALSDGASAMLIMSEEKANELGLKIRARIKGMAIAGCDPSIMGYGPVPATQKALKRAGLAIEDMDVVELNEAFAAQSLPCAKDLGLLEVMDEKVNLNGGAIALGHPLGCSGARISTTLINLMEAKDAKYGLATMCIGLGQGIATVFERP
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_XANOP
Sequence: MVKIRLTRGGAKKRPFYHIIVTDVRSARDGRNIERLGYYNPVAQGAEPRVVLDTARVDHWVGNGAQLTDKVRNLYREAKSQAAAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: 5DNU_SALCH
Sequence: MKQSHFFAHLSRMKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGQLNAERIALLAMYHDASEVLTGDLPTPVKYFNSQIAQEYKAIEKIAQQKLVDMAPDELRDIFAPLIDENAWSEEEQAIVKQADALCAYLKCLEELSAGNNEFGLAKTRLEKTLELRRSQEMDYFMAVFVPSFHLSLDEISQDSPL
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase YfbR, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAMP8_RAT
Sequence: MEASGSAGNDRVRNLQSEVEGVKNIMTQNVERILARGENLDHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVIICVIVLIILILIILFATGTIPT
What is the function of this protein?
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes.  SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion.  VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (By similarity).  Also required for dense-granule secretion in platelets (By similarity).  Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity).  Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (PubMed:12737809).  Involved in the homotypic fusion of early and late endosomes (PubMed:10982406, PubMed:11029036).  Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity).
What are the official names of this protein?
Vesicle-associated membrane protein 8, VAMP-8, Endobrevin, EDB.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Midbody. Cell membrane; Single-pass type IV membrane protein. Zymogen granule membrane; Single-pass type IV membrane protein. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (PubMed:9614193). Sub-tight junctional domain in retinal pigment epithelium cells (PubMed:11029036). Midbody region during cytokinesis (PubMed:12414999). Lumenal oriented, apical membranes of nephric tubular cell (PubMed:11208143). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (By similarity).
Protein: DAPX_BACSU
Sequence: MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPHHVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAIDAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTPNTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATYLRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAVTNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMALLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNGV
What is the function of this protein?
Essential for murein biosynthesis (PubMed:29280348).  Probably catalyzes the conversion of L-2-acetamido-6-oxopimelate to N-acetyl-LL-2,6-diaminopimelate (Probable).
What are the official names of this protein?
Probable N-acetyl-LL-diaminopimelate aminotransferase, Putative aminotransferase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_I88A4
Sequence: MAIIYLILLFTAVRGDQICIGYHSNNSTEKVDTILERNVTVTHAEDILEKTHNGKLCKLNGIPPLELRDCSIAGWLLGNPECDILLTVPEWSYIIEKENPRNGLCYPGSFNDYEELKHLISSVTHFEKVKILPRNEWTQHTTTGGSQACADYGGPSFFRNMVWLTKKGSNYPIAKRSYNNTSGEQMLIIWGIHHPNDESEQRALYQNVGTYVSVGTSTLNKRSSPEIATRPKVNGQGGRMEFSWTILDIWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGKLENCETKCQTPLGAINTTLPFHNIHPLTIGECPKYVKSERLVLATGLRNVPQIESRGLFGAIAGFIEGGWQGMVDGWYGYHHSNDQGSGYAADKESTQKAIDGITNKVNSVIEKMNTQFGAVGKEFSNLERRLENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNAKELGNGCFEFYHKCDDECMNSVKNGTYDYSKYEEESKLNRTEIKGVKLSNMGVYQILAIYATVAGSLSLAIMIAGISIWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: RL37_METS5
Sequence: MKGTPSFGKMNKGGSHIRCRRCGRNSYNPTKHKCAACGFGKSKRITRYSWKTKKVNGVRLK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L37e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL37 family.
Protein: ODO2_RICCN
Sequence: MRVKIIVPSLGESITEATIAKWYKKQGDSVKTDELLLEIETEKVTLEVNAPCNGTIGKISKTEGANVAVGEEIGEINEGASANTAGTNNESAKAQAVTQPTSEKPAVANNTLAPSVQKLVTENKLDPNNIKGTGRDGRITKGDVLATINTTTTSAPAISKSNEERVQRVRMSRLRKTIAQRLKDSQNTAAILTTFNEIDMSKVIALRNQYKEEFEKKHAVKLGFMSFFVKATIEALKLIPSVNAEIDGDDLVYKNYYDIGVAVGTEQGLVVPVVRDADKMGFAEVEKTIGILAKQAREGKLSMADLSGGTFSISNGGVYGSLLSTPIINPPQSGILGLHKTEERAVVIDGKIEIRPMMYIALSYDHRIIDGKEGVSFLVKIKQLIENPEKLLLNL
What is the function of this protein?
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: PSMF1_BOVIN
Sequence: MAGLEVLFASAAPAITCAQDALVCFLHWEVVTHGYYGLGAGDQPGPNDKKSELLPVEWNSNKDLYVLRYESKDGSRKLLVKAVTVENSMIINVLEHGSQQVSDLTLNLNDYIDSEHLVDFHRVYKNSEELRSRIVSGIITPIHEQWEKANLSPHREFPPATAREVDPLRIHPQHPHTSRQPTWCDPLGPFAVGGEDLDPFGCRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPSGPNPDHLPPPGYDDMYL
What is the function of this protein?
Plays an important role in control of proteasome function.  Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome.  Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity).
What are the official names of this protein?
Proteasome inhibitor PI31 subunit.
What is the protein family that this protein belongs to?
Belongs to the proteasome inhibitor PI31 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: AA2BR_CHICK
Sequence: MNTMKTTYIVLELIIAVLSIAGNVLVCWAVAINSTLKNATNYFLVSLAVADIAVGLLAIPFAITISIGFQVDFHSCLFFACFVLVLTQSSIFSLLAVAIDRYLAIKIPLRYNSLVTGKRARGLIAVLWLLSFVIGLTPLMGWNKAMSGCPNSTNETGADHGAGHHGCFISCLFENVVTMSYMVYFNFFGCVLLPLIIMLGIYIKIFMVACKQLHQIELMGNSRTTLQKEVHAAKSLAIIVGLFAFCWLPLHILNCITHFHEEFSKSKPEWVMYVAIILSHANSVINPIIYAYRIRDFRYTFHKIISKILCKTDDFPKCTTDNNQHLTVTNVNAPAASVTI
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
What are the official names of this protein?
Adenosine receptor A2b, Adenosine receptor 2b.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KTHY_STAA3
Sequence: MSAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIVLEGNDMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIKNSRDQNRLDQEDLKFHEKVIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SL1_BITAR
Sequence: MGRFIFISFGLLVVFLSLSGTEADCLPDWFHYEGHCYRVFDEPKTWADAEKFCSEQANGGHLVSVHSRKEAGLVGVLAYQTLESPIVWMGLSKVWNQCDWGWTNGAKLKYEARAEESYCIHITSKKKEWKSLPCRNYGHFVCKSPA
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec 1, C-type lectin 1.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZEA1_MAIZE
Sequence: MAAKIFCLLMLLGLSASAATATIFPQCSQAPIASLLPPYLSPAVSSVCENPILQPYRIQQAIAAGILPLSPLFLQQSSALLQQLPLVHLLAQNIRAQQLQQLVLANLAAYSQQQQFLPFNQLAALNSASYLQQQQLPFSQLPAAYPQQFLPFNQLAALNSPAYLQQQQLLPFSQLAGVSPATFLTQPQLLPFYQHAAPNAGTLLQLQQLLPFNQLALTNLAAFYQQPIIGGALF
What is the function of this protein?
Zeins are major seed storage proteins.
What are the official names of this protein?
Zein-alpha A30, 19 kDa zein A30.
What is the protein family that this protein belongs to?
Belongs to the zein family.
Protein: RASH_HUMAN
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
What is the function of this protein?
Involved in the activation of Ras protein signal transduction (PubMed:22821884).  Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151).
What are the official names of this protein?
GTPase HRas, H-Ras-1, Ha-Ras, Transforming protein p21, c-H-ras, p21ras.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with RACK1 to the perinuclear region.
Protein: NAGZ_ECOLI
Sequence: MGPVMLDVEGYELDAEEREILAHPLVGGLILFTRNYHDPAQLRELVRQIRAASRNRLVVAVDQEGGRVQRFREGFTRLPAAQSFAALSGMEEGGKLAQEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPQKALAIASRFIDGMHEAGMKTTGKHFPGHGAVTADSHKETPCDPRPQAEIRAKDMSVFSSLIRENKLDAIMPAHVIYSDVDPRPASGSPYWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERGQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSRQELMDSARWKAISTRLNQLHERWQEEKAGH
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.  Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4E_SULIK
Sequence: MAHITRFETPWFLVISKKQYKWTVRPNAGPHPIEKSIPLAVVIRDYLKLAETVREAKHIIFDGKVLVDGKVRKDYKYPVGLMDIVSIPSADLYFRVIPDNVRFMRLSKISADEAHYKYVRIMNKTTVKGGSIQLNLEDGRNILVDKETAKSFKTLMTLKIELPSQNIVDSFIISEGSYAIFVGGKNVGIHGVVKNINLSKFKSRKYSVITLESKDGNTYQTNLMNVMSIGREKSDMRVD
What are the official names of this protein?
30S ribosomal protein S4e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: CCL1_MOUSE
Sequence: MKPTAMALMCLLLAAVWIQDVDSKSMLTVSNSCCLNTLKKELPLKFIQCYRKMGSSCPDPPAVVFRLNKGRESCASTNKTWVQNHLKKVNPC
What is the function of this protein?
Cytokine that is chemotactic for neutrophils.
What are the official names of this protein?
C-C motif chemokine 1, P500, SIS-epsilon, Small-inducible cytokine A1, T-cell activation protein 3, TCA-3, TCA3.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.