PharMolix/UniProtQA huggingface dataset:
Protein: EPC1_HUMAN
Sequence: MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIPIIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAALPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHHLDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSDNDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSKTLDSASAQFAASALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRTLSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT
What is the function of this protein?
Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270).  The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538).  The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity).  In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463).
What are the official names of this protein?
Enhancer of polycomb homolog 1.
What is the protein family that this protein belongs to?
Belongs to the enhancer of polycomb family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RR3_ORYSA
Sequence: MGQKINPLGFRLGTTQNHHSFWFAQPKNYSEGLQEDKKIRNCIKNYIQKNRKKGSNRKIEADSSFEVITHNKKMDSGSSSEVITHIEIQKEIDTIHVIIHIGFPNLLKKKGAIEELEKDLQKEVNSVNQRLNIGIEKVKEPYRQPNILAEYIAFQLKNRVSFRKAMKKAIELTKKTDIKGVKVKIAGRLAGKEIARAECIKKGRLPLQTIRAKIDYCCYPIRTIYGVLGVKIWIFVDEE
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MDCG_XANCB
Sequence: MAGRHALVWLRADAPSQALTPGAQPRLQAWFAAGFPAVVARRDGAEQPGQVRLGVPLPPAQGKQRIALCAQVSDIARSVPALALPEVISHAPPQWQAALHALQAQATAIGMQPRVFGSFAFQAVTGLPYVHAASDVDLLWTLDTPTQAHAVVTLLQQWEHVTARRADGELLLPDGNAVNWREYAGDAQQVLVKRNDGCRLLPRTALFPERCAA
What is the function of this protein?
Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-[acyl-carrier-protein] of the malonate decarboxylase to yield holo-[acyl-carrier-protein].
What are the official names of this protein?
Phosphoribosyl-dephospho-CoA transferase, Malonate decarboxylase holo-[acyl-carrier-protein] synthase, Holo-ACP synthase.
What is the protein family that this protein belongs to?
Belongs to the MdcG family.
Protein: BQMT2_ORYSJ
Sequence: MAMASSAYAPAGGVGTHSAPGRIRPPRGLGFSTTTTKSRPLVLTRRGGGGGNISVARLRCAASSSSAAARPMSQPRFIQHKKEAFWFYRFLSIVYDHVINPGHWTEDMRDDALEPADLYSRKLRVVDVGGGTGFTTLGIVKRVDPENVTLLDQSPHQLEKAREKEALKGVTIMEGDAEDLPFPTDTFDRYVSAGSIEYWPDPQRGIKEAYRVLRLGGVACMIGPVHPTFWLSRFFADMWMLFPKEEEYIEWFKKAGFKDVKLKRIGPKWYRGVRRHGLIMGCSVTGVKREHGDSPLQLGPKVEDVSKPVNPITFLFRFLMGTICAAYYVLVPIYMWIKDQIVPKGMPI
What is the function of this protein?
Involved in a key methylation step in both tocopherols (vitamin E) and plastoquinone synthesis.  Catalyzes the conversion of 2-methyl-6-phytyl-1,4-hydroquinone (MPBQ) to 2,3-dimethyl-6-phytyl-1,4-hydroquinone (DMPQ, a substrate for tocopherol cyclase), and 2-methyl-6-solanyl-1,4-benzoquinone (MSBQ) to plastoquinone (By similarity).
What are the official names of this protein?
2-methyl-6-phytyl-1,4-hydroquinone methyltransferase 2, chloroplastic, 37 kDa inner envelope membrane protein, E37, MPBQ/MSBQ methyltransferase, Protein VTE3 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Single-pass membrane protein.
Protein: RCA_PHAVU
Sequence: MAASLSTVGAVNRTLLNLNGSGGGASGPSSAFFGTSLKKVISSRVPNSKLTSGSFKIVAADKEIEETQQTEGDRWRGLAYDVSDDQQDITRGKGLVDSLFQAPMDAGTHYAVISSHKYLSAGLRQYNFDNIKDGFYIAPAFLDKLVVHIAKNFMTLPNIKVPLILGVWGGKGQGKSFQCELVFAKMGINPIMMSAGELESGNAGEPAKLIRQRYREASDLIKKGKMCVLFINDLDAGAGRLGGTTQYTVNNQMVNATLMNIADNPTNVQLPGMYNKEDNARVPIIVTGNDFSTLYAPLIRDGRMEKFYWAPTREDRIGVCKGIFRTDGVPEKDIVELVDKHPGQSIDFFGALRARVYDDEVRKWISGVGVDSVGKKLVNSKEGPPTFDQPKMTLDKLLLYASMLVQEQENVKRVQLADQYLNEAALGNANEDAIKSGSFFK
What is the function of this protein?
Activation of RuBisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase; EC 4. 1. 1. 39) involves the ATP-dependent carboxylation of the epsilon-amino group of lysine leading to a carbamate structure.
What are the official names of this protein?
Ribulose bisphosphate carboxylase/oxygenase activase, chloroplastic, RA, RuBisCO activase.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO activase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RUVB_SYNWW
Sequence: MLDERLISSHLLDEDDNNENSIRPGRLSEYIGQEKVKENVEVFITAARERKESLDHVLLSGPPGLGKTTLASIIANEVGKPIRKTSGPAIERPGDLAAILTNLEPGEVLFIDEIHRLNRNVEEIMYPAMEDYVIDIIIGKGPAARTLRLDLPPFTLIGATTRPGLLSSPLRDRFGISCRLDFYTPLELSEIILRAARILEISLDKEGATEIAGRSRGTPRVANRLLRRVRDYALVKGNGNIDFSLAKWALEMLEIDECGLDVMDRMILEAIIGKFSGGPVGLDTLAASVSEESDTISDVYEPYLLKLGFIQKTPRGRMATEHAYRHLGYPLKGNLEGKGLFSDA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ISPH_EXISA
Sequence: MKVKKISPRGYCYGVVDAMKLANEAVANPDLPRPIHILGMIVHNRHVTQAFEDLGVKTVDGEDRMQALETIDRGTVVFTAHGISPLVRKRAIEKGLTIVDASCPDVLVTHDLIREKTAEGYDVIYIGKHGHPEPEGAIGVAPDHVHLIQYEHEIDQLPSRLFERKILVTNQTTMSQWDVSALIETIQARYPHVEVHNEICNATQVRQEAVAEQAGDCELLIVVGDPKSNNSNRLAQVSKEIAGTNAYRIGDLSELDLNWLEGVETVAVTSGASTPTPITKKVIDFLSQYDPDDLSTHDKTPFLELRSILPKVKALRK
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RECA_LIMRD
Sequence: MADQRKAALDVAIRKIEKNFGKGSIMRMGDATDMKVASVSSGSLAIDKALGIGGYPRGRIVEIYGPESSGKTTVALHAVAEVQRQGGTAAYIDAENALDPQYAEALGVNIDDLLLSQPDSGEEGLEIADALISSGAVDLVIVDSVAALVPRAEIDGDMGDTHVGLQARLMSQALRKLSGEINKTKTIAIFINQIREKVGVMFGNPETTTGGRALKFYSTIRMEIRRAEQIKNGTDVIGNKAKVKIVKNKVAPPFKRCEVDIMYGEGISKTGELLDMAVENDLVDKSGAWYSYGSERIGQGRENAKKWLKEHPDSMNELMDKVRVANGMEPLNEKSTKETADDKASGKTGENKQETIEEASKE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O16L_CONTE
Sequence: MKLTCMMIVAVLFLTAWTFVTAVPHSSNALENLYLKARHEMENPEASKLNTRDDCEPPGNFCGMIKIGPPCCSGWCFFACA
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-conotoxin-like TxMKLT1-0223.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MURG_BURM9
Sequence: MTSTQRTLMVMAGGTGGHVFPGLAVAHRMQAQGWRVVWLGNPAGMEATLVPRHGIPMEYVRFGGLRGKGLATKFALPFNLLRACAQSLRALRRVKPDVVLGMGGYITFPAGLVTVLTGRPLVLHEQNSIAGLTNKVLAKLAKRVLVAFPGALPNAEWTGNPIRTELARTEPPQARYAARSGKLRLLVVGGSLGAAALNEVVPRALALLAPDERPQVVHQAGAKHIDTLKENYEAAGLSCGSDVALVPFIDDMASAYANADLVICRSGAMTVAEIAAVGVAALFVPFPHAVDDHQTTNAEFLAEQGAAVLVQQRDLSAELLADWLRGQSRDSLAAMAERSRSLAKPDATDEVARVCAAVAGANLEGKQ
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: APAH_ERWT9
Sequence: MSTYLIGDIHGCYHELQSLLDQVQFNPETDQLWLTGDLVARGPDSLEVLRFVRALGNCVRLVLGNHDLHLLAVYAGIGRNKTKDRLSDLLEADDVDELINWLRRQPLIQVDEEKKLVMAHAGITPQWDIATAQACAREVEAVLGSDTYPLFLNAMYGDMPNSWSPELGGLARLRFSTNALTRMRYCFPNGQLDMIAKEPPDSAPPPLKPWFDIPGPVSRDYTIVFGHWASLEGKGTPEGIVGLDTGCCWGGNLSMLRWEDKQMFIQPSRREKQL
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: RS12_TRYBB
Sequence: MAEETSLVADKVPEPAVIDAVADAMPDSLEDALRIVLMKARETNGLICGLSEVTRALDRRTAHLCVLADDCEDEEYKKLVTALAKQNNIDLVSMDEREKLAQWAGLTRMAADGSVRKTLKCSCLAVRDFGERTKALDYLLSQLQ
What are the official names of this protein?
40S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS12 family.
Protein: O166_CONAA
Sequence: CKQAGESCDIFSQNCCVGTCAFICIE
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.
What are the official names of this protein?
Delta-conotoxin Am2766, Am 2766, Delta-Am2766.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AGLF_RHIME
Sequence: MEQLIAAILTMVAGVLVCAAYFWSTNLVLDWIFPSKGKFGAVASRNLRIANSIRPWLFLAPALLALTLYLVYPVVQSVWLSLHGRGGQNFVGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDRIWWGNIAKTLIFMPMAISFVGAAVIWKFIYDYRAAGSEQIGLLNAIVVALGGEPQAWITLPFWNNFFLMVILIWIQTGFAMVILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTITILVLKVFDIVLAMTNGQWQSQVLANLMFDWMFRGGGDFGRGAAIAVVIMILVVPIMIWNIRNATRESGGH
What is the function of this protein?
Part of the binding-protein-dependent transport system for alpha-glucosides such as sucrose, maltose and trehalose.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Alpha-glucoside transport system permease protein AglF.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECF_NITOC
Sequence: MMHITHLDIRNFRNLKHIELHPSKGVNILSGANSSGKTSFLEAIYLLGLGRSFRTVQLISAIQAGMESLRVVAKVKQVGGSHTAGVEFGPAGFRARINKDTVKKRSQLATQLPLLYMSSYSHVVLDGGPRYRRQWLDWSLFHLEPGFHDLWWCYQRTLKQRNHVLRVHKPSWQQEINAWNKKLSTYGEQITSLREAILFKLQDSVSQLFTALAHQPISPVTMEFKQGWARTVRLEEILNESLNYDRAAGYTRYGPHRAEVAFYVDGKDVREILSRGQQKVFCYSLALSQANLLYRTKEQNCIFLIDDFTSELDADHRKRLLTLLNKLGMQVFATTIESLGSEIKAHPNIKEFHVKLGQVEEMV
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_NATPD
Sequence: MNVDFGNALAAEAVTGVSEASLERLDDRVADAHDRIEANIEARRFGYASLALPTDTDPDAIYEAVSGFDPEAVLTVGIGGSALGAETITAALGAESHYTLDNVDPAPTRQLLDELPLSSTLVNVVSRSGTTAETLANFLVVREAMADAGVDWTDRTVVTTGAEGPLRTLADAHDLPSCTVPEGVPGRFSALSAVGLLPAAALGCDIEAVLAGGAAGRESLAPSLFESPAYAYGAVAYATEQRGATTNAIVPYAEQLEPFAEWFAQLWAESLGKDGLGQTPARALGATDQHSQLQLYRAGRKDKLVTLVRPRERAGVDIPETDIDALSYLGGESLESLLDAEFEATEASLAAAGQPNVRIELDSLDAHGVGELLYGMEAACILYGELLGIETFTQPAVEWGKRAARGLLGGGDFEEAEAVADKTVRRVE
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Probable glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_NEIG1
Sequence: MPNFFKFHTVIERHWQKPYPVLSFLLKPLSGLFAKIAAKWRADFLSGKRQSEKLSVPVVVVGNIHAGGTGKTPIAAALVSGLQEKGVKVGIISRGYGRKSKAVYVLNAASRAEDAGDEPLLLFRKTGAPTAVGSSRVEAGRALLAAHPELELIVADDGLQHYALQRDVEIAVFPAADTGRTDLDLLPNGNLREPLSRLESVDAVVVGGRAADGFMPSEHLFGSRIEAGAVYRLNRPSEKLDISTLSGKRVAAVAGIARPQRFFDTLTHMGIRLDQTVALPDHADIFNRDLPPADVVLVTEKDAVKFSDGICTDNVWVLPVCAIIEPDLAEFVLERLEGVPKAV
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: SSB_STRMU
Sequence: MINNVVLVGRMTRDAELRYTPSNQAVATFTLAVNRNFKNQNGEREADFINIVIWRQQAENLANWAKKGTLLGITGRIQTRNYENQQGQRVYVTEVVADNFQILESRATREGQSNSYNAGGNNNFGGNNFSSQGSSQSQTPNFARDESPFGDSNPMDISDDDLPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: M1_I72A8
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVATTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: TFB5_DEBHA
Sequence: MPSAIKGVMVQCDPSIKALILKIDSERHDIVIEELDETHLVIDSNKVQAVKNELNRLLSKNIYNPFDEQ
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit TFB5, TFIIH subunit TFB5, RNA polymerase II transcription factor B subunit 5.
What is the protein family that this protein belongs to?
Belongs to the TFB5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPB1_ARCFU
Sequence: MRCWLENLSGGRKMKFGEFGGRFVPEVLIPPLEELEKAYDRFKDDEEFKARLEYYLKSYAGRPTPLYFAENLSRELGVKIYLKREDLLHGGAHKINNTIGQALLAKFMGKKRVIAETGAGQHGVATAMAAALLGLEAEIYMGAEDYERQKMNVFRMELLGAKVTAVESGSRTLKDAINEALRDWVESFEHTHYLIGSVVGPHPFPTIVRDFQAVIGKEARRQIIEAEGGMPDAIIACVGGGSNAMGIFHPFLNDDVRLIGVEAGGEGIESGRHSASLTAGSKGVLHGMLSYFLQDEEGMMLDTHSVSAGLDYPGVGPEHAYLKETGRCEYVTVNDEEALRAFKTLSKLEGIIPALESAHAIAYAMKMAEEMQRDDVLVVNLSGRGDKDMDIVRRRLA
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain 1.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: HSPQ_KLEP3
Sequence: MIASKFGIGQQVRHTLLGYLGVIVDVDPEYSLAEPEEDEIAANDELRAAPWYHVVMEDDDGQPIHTYLAEAQLSSETRDEHPEQPSLDELAKTIRQQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUNIP_BOVIN
Sequence: MRRRGPEKEEEACGVWLDAAALKRRKTQTQLIKSSTKMLTLLPGERKAKISFTQRSCPSAGTRQTSIASFLTSQQGKTNGADQRSVSSHTESQTNKESKEDATQLEHLTQGLRADFMAPPLATSTPADIQEARLSPQSLKASCQHGIGTPYLTVPCLFRPDTSVCAGASKASLACSFAHDLESSCLLDQKEGEDSSCEREWLQGSKKNNYQSVERHSKTTGHKGHQLLDKTNLENVSAKRSRQAPVLQTYKDSRRGANMKAVKQSSCPIPGFSWDSERNDKDSWSQLFTEDSQGQRVIAHNSRAPFRDVTNDQNQGYGRVPNSLWAQCQDRTTQFNLQPDSLFTQDSEGNQVIRHQA
What is the function of this protein?
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination.  Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair.  Inhibits non-homologous end joining (NHEJ).  Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
What are the official names of this protein?
Aurora kinase A and ninein-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the AUNIP family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks. Localizes to the centrosome in interphase and to the spindle pole in metaphase.
Protein: TREA_YEAST
Sequence: MSQVNTSQGPVAQGRQRRLSSLSEFNDPFSNAEVYYGPPTDPRKQKQAKPAKINRTRTMSVFDNVSPFKKTGFGKLQQTRRGSEDDTYSSSQGNRRFFIEDVDKTLNELLAAEDTDKNYQITIEDTGPKVLKVGTANSYGYKHINIRGTYMLSNLLQELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQFWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQASQMHPSLKLEVEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLIGYPYAVPGGRFNELYGWDSYMMALGLLEANKTDVARGMVEHFIFEINHYGKILNANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASIKEYKTVWTASPRLDPETGLSRYHPNGLGIPPETESDHFDTVLLPYASKHGVTLDEFKQLYNDGKIKEPKLDEFFLHDRGVRESGHDTTYRFEGVCAYLATIDLNSLLYKYEIDIADFIKEFCDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMWDDESGFFFDYNTKIKHRTSYESATTFWALWAGLATKEQAQKMVEKALPKLEMLGGLAACTERSRGPISISRPIRQWDYPFGWAPHQILAWEGLRSYGYLTVTNRLAYRWLFMMTKAFVDYNGIVVEKYDVTRGTDPHRVEAEYGNQGADFKGAATEGFGWVNASYILGLKYMNSHARRALGACIPPISFFSSLRPQERNLYGL
What is the function of this protein?
Hydrolyzes intracellular trehalose to glucose (PubMed:22320399, PubMed:29087344) (Probable).  The disaccharide trehalose serves as a storage carbohydrate that is mobilized during nutrient stress (Probable).  Regulates the level of trehalose as a protectant for cell integrity during heat stress (PubMed:7883049, PubMed:7730323).
What are the official names of this protein?
Cytosolic neutral trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU2_SHEFN
Sequence: MAKAKFERIKPHVNVGTIGHVDHGKTTLTAAISAVLSKTYGGEVKNFAQIDNAPEERERGITINTSHIEYDTPIRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLSRQVGVPFIIVFMNKCDMVDDEELLELVEMEVRELLSEYDFPGDDLPVIQGSALKALEGQPEWEAKILELAEALDTYIPEPARDIDKPFLLPIEDVFSISGRGTVVTGRVERGIVRVSDEVEIVGVRPTTKTTCTGVEMFRKLLDEGRAGENCGVLLRGTKRDDVERGQVLAKPGSINPHTTFESEVYVLSKEEGGRHTPFFKGYRPQFFFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIYPIAMDDGLRFAIREGGRTVGAGVVAKIIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NO5_PEA
Sequence: MASSSSPIFLMIIFSMWLLFSYSESTEYLVRDSENSWKVNFPSRDALNRWVTRHQLTIHDTIDVVDEDDCNTEIRSKLGGDFVVTKRPLVLPPLITLPLSPSPAPAPSLSGAAAGHGFIVWLGASLPMLMFLIWL
What is the function of this protein?
Involved in the infection process during the plant-rhizobium interaction.
What are the official names of this protein?
Early nodulin-5, N-5.