PharMolix/UniProtQA huggingface dataset:
Protein: VMP01_EULPE
Sequence: MDLFILTRFILFLSFFMKSIHCQYSESQESGHNRNAPDKELTTEEFQLIFHQSQTVDIEYDFINITTEMIETERKVSFTIDGKEYHLSLTPAASQSVLPYGTKIKSAIWWTDNDTHIHEEDYSDERWDSRAIYENLEIMATILVRTENGTSYYDGVFVKYSNEGVRSLPGRLMNIYGANYHFVYDSNGSVYDVVLNGQDEPAVPADMASKIIFYSETPCTCRLLIIQDLLMKTSRRLSSISTIFWNAVNLRFRPVQHPKVNIIITGIVIAKNEAAFQHVYRARYSKNSKLVHTGRVIDNGRYFFGTNFDPYYDNYDASFTMASMDDPTGKGGATVIGGICSSSNNIAYIRDVGSYSGVKVATHELGHLLNGQHDSDTTCSEKINDNIYTIMAKQGSTKASKFVWSSCTLTAFANFSKTTSAACLKDTYRKQ
What is the function of this protein?
The recombinant protein has gelatinase activity.  In vivo, injection of this recombinant into fifth instar L. oleracea (host) larvae results in partial insect mortality associated with the molt to sixth instar, with surviving insects showing retarded development and growth (By similarity).
What are the official names of this protein?
Venom metalloproteinase 1, EpMP1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the venom metalloproteinase (M12B) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOB_SOLLC
Sequence: MLGDGNEGISTIPGFNQIQFEGFCRFIDQGLTEELYKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVSAGLIWKNSRDMQEQTIFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYRSELDHNGISVYTGTIISDWGGRSELEIDRKARIWARVSRKQKISILVLSSAMGLNLREILENVCYPEIFLSFLNDKERKKIGSKENSILEFYQQFACVGGDPVFSESLCKELQKKFFQQRCELGRIGRRNMNRKLNLDIPQNNTFLLPRDILAAADHLIGLKFGMGALDDMNHLKNKRIRSVADLLQDQFGLALVRLENVVRGTICGAIRHKLIPTPQNLVTSPPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTASFRIRDIHPSHYGRICPIDTSEGINVGLIGSLSIHARIGHWGSLESPFYEISERSTGVRMLYLSPGSDEYYMVAAGNSLALNRDIQEEQVVPARYRQEFLTIAWEQVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQAALDSGALAIAEREGRIVYTNTHKILLAGNGDILSIPLVIYQRSNKNTCMHQKFRVPRGKCIKKGQILADGAATVGGELALGKNVLVAYMPWEGYNSEDAVLISERLVYEDIYTSFHIRKYEIHTHVTSQGPEKVTNEIPHLEAHLLRNLDKKGIVMLGSWVETGDILVGKLTPQVVKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWIQKRGGSSYNPETIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRSVDMVFNPLGVPSRMNVGQIFECSLGLAGSLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRIFDGRTGNPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRAKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPNPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS14_SYNY3
Sequence: MAKKSMIERDKRRSRLVAKYAAKREALKEEFRQAETLEDKLAVHQKLQDLPRNSAPNRRRNRCQVTGRPRSYYRDFGLCRNVLREWAHQGLLPGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ATPD_GEOMG
Sequence: MISNAIARRYAKALVQLGAEEDAVDRFGAELGQFAALLEGNADIDSVLKSPAYRIEAKREILKDVLAKLSLSGTVSNFLQVLLDRGRISFLPQIAHSYAAFADELSGVIRPVLTSAFPLEDAQVESMKGALVKATGKKVQLSVQVEPSLIGGVITKIGDKVFDGSVRTQLNRIQDILQKG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YQGF_STAA8
Sequence: MLQHKILGLDVGSRTVGIAISDIMGWTAQGLDTLRINEENNELGIDQLVDIIKKHNVGTVVIGLPKNMNNSIGFRGEASLTYKEKLLEAYPSIEIVMWDERLSTMAAERSLLEADVSRQKRKQVIDKMAAVFILQGYLDSLH
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_RALSO
Sequence: MNKKQRDAKNKKRFQQQNPLFKRKKFCRFTVAGVEQIDYKDLDTLKDFIGENGKITPARLTGTRSHYQRQLDTAIKRARFLALMPYTDQHKH
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MTGA_PSEPF
Sequence: MLRLFLRRFTKALLWFAGGSVLLVLVFRFVPPPGTALMVERKIESWVDGEPIDLQRTWKPWDEISDDLKVAVIAGEDQKFPEHWGFDLSAIKAALAHNELGGSIRGASTLSQQVSKNLFLWSGRSYLRKGLEAWFTALIEVFWPKQRILEVYLNSVEWDDGVFGAEAAARHHFGVGARSLSRQQASYLAAVLPNPRVWSASHPTAYVSRRAGWIRQQMSQLGGDSYLLTLNDSRRAPWAQ
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SSRP_CAUVN
Sequence: MSKPIAENRRARFDYFIEETFEAGIMLTGTEVKSLRTGRANIAESYASVEGREIVLINADIPPYGHANRFNHEPRRHRKLLLHRRQIDKLIGAVQREGRTLVPIKLYWNDKGLAKLEVGLAKGKKLHDKRDTAAERDWQRDKARLMKGDRGD
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation (By similarity).  Binds to and required for stability of mature tmRNA, which it protects from degradation by RNase R (rnr) (PubMed:12511504).  Required for correct localization of tmRNA (PubMed:19805312).  In this organism the ssrA gene for tmRNA is circularly permutated and is processed into 2 pieces to function (PubMed:10884408).  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes (By similarity). Colocalizes with tmRNA in regularly spaced foci indicative of a helix-like structure: in the absence of tmRNA this protein still localizes correctly. Although RNase R (rnr) localizes in a similar helix-like pattern, the 2 helices are out of phase.
Protein: CU18A_LOCMI
Sequence: GYLGAPAVVAPGAPLAARAYAAPAYAAPLARYAAPVARAYAAPVARAYAPAVAAAPAAVEYDPHPQYSFAYNVQDAHTGDSKTQHESRDGDVVQGSYSLAEPDGSIRVVDYTADPVNGFNAVVHKEAGAHPAAAPVAVAAPVAHAPVAVAAPVRAYAAPLARAAYAAPIARASYGPALAYGGAYH
What is the function of this protein?
Component of the cuticle of migratory locust which contains more than 100 different structural proteins.
What are the official names of this protein?
Cuticle protein 18.6, isoform A, LM-ACP 18.6A, LM-18.6A.
Protein: RUVC_NEIMB
Sequence: MAASVRILGIDPGSRVTGFGVIDVRGRDHFYVASGCIKTPADAPLADRIAVIVRHIGEVVTVYKPQQAAVEQVFVNVNPASTLMLGQARGAALAALVSHKLPVSEYTALQVKQAVVGKGKAAKEQVQHMVVQMLGLSGTPQPDAADGLAVALTHALRNHGLAAKLNPSGMQVKRGRFQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: 3608L_ASFK5
Sequence: MLSLQTLAKKALAKQSVPEEYHYILKYCGLWWQNKPIHLCDYCNYVIVNSTPFKGELHLDVALIMAIKENNHDLIRLFTEWGANIYYGLSCARTEYTQELCRKLGAKDGLDKKDIFISLLHHKTSNNIILCHEIFNKNPMLEILNMQDFGEEIHRELKHLIFYILDNVPINTLNKYWYAIAVKYKLKRAISFFYQTYDHLNMWRLMCAISFNNVFDLHEIYEQKIVHMDIDKMMHLACMEDDNFLTIYYCFVLGADIDQAINVTLWHHQTNNLCFCKDLKDLKEQNGLTARPLLLPNITDPKKIYTMLKNYLPISSNSR
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-8L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: RL7_CANGA
Sequence: MAAEKILKPESQLKKAKYDEKKSEEFLKARAARRVANKQKRAAILERNAAHQKEYEAAERAVIDAKREAKASGSYYVEAQPKLVFVVRIKGINKIPPKPRKVLQLLRLTQINSGTFVKVTKATSELLKLIEPYVAYGYPSYSTVRQLVYKRGHGKINKQRIALSDNAIVEANLGKFGILSIDDLIHEIVTVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGAFGNREQFINKLVKAMN
What are the official names of this protein?
60S ribosomal protein L7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: FAS1_DROME
Sequence: MLNAAALLLALLCAANAAAAADLADKLRDDSELSQFYSLLESNQIANSTLSLRSCTIFVPTNEAFQRYKSKTAHVLYHITTEAYTQKRLPNTVSSDMAGNPPLYITKNSNGDIFVNNARIIPSLSVETNSDGKRQIMHIIDEVLEPLTVKAGHSDTPNNPNALKFLKNAEEFNVDNIGVRTYRSQVTMAKKESVYDAAGQHTFLVPVDEGFKLSARSSLVDGKVIDGHVIPNTVIFTAAAQHDDPKASAAFEDLLKVTVSFFKQKNGKMYVKSNTIVGDAKHRVGVVLAEIVKANIPVSNGVVHLIHRPLMIIDTTVTQFLQSFKENAENGALRKFYEVIMDNGGAVLDDINSLTEVTILAPSNEAWNSSNINNVLRDRNKMRQILNMHIIKDRLNVDKIRQKNANLIAQVPTVNNNTFLYFNVRGEGSDTVITVEGGGVNATVIQADVAQTNGYVHIIDHVLGVPYTTVLGKLESDPMMSDTYKMGKFSHFNDQLNNTQRRFTYFVPRDKGWQKTELDYPSAHKKLFMADFSYHSKSILERHLAISDKEYTMKDLVKFSQESGSVILPTFRDSLSIRVEEEAGRYVIIWNYKKINVYRPDVECTNGIIHVIDYPLLEEKDVVVAGGSYLPESSICIILANLIMITVAKFLN
What is the function of this protein?
Neural cell adhesion molecule.
What are the official names of this protein?
Fasciclin-1, Fasciclin I, FAS I, FCN.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: TRPE_PSEPU
Sequence: MNREEFLRLAAVGYNRIPLACETLADFDTPLSIYLKLADQPNSYLLESVQGGEKWGRYSMIGLPSRTVMRVHGYHVSILHDGVEVESHDVEDPLAFVESFKDRYKVADIPGLPRFNGGLVGYFGYDCVRYVEKRLGVSPNPDPLGVPDILLMVSDAVVVFDNLAGKMHAIVLVDPAEEQAFEQGQARLQGLLETLRQPITPRRGLDLSGPQAAEPEFRSSYTREDYENAVGRIKEYILAGDCMQVVPSQRMSIDFKAAPIDLYRALRCFNPTPYMYFFNFGDFHVVGSSPEVLVRVEDNLVTVRPIAGTRPRGATEEADRALEDDLLSDDKEIAEHLMLIDLGRNDVGRVSSTGSVRLTEKMVIERYSNVMHIVSNVAGQLREGLTAMDALRAILPAGTLSGAPKIRAMEIIDELEPVKRGVYGGAVGYFAWNGNMDTAIAIRTAVINDGELHVQAGGGIVADSVPALEWEETINKRRAMFRAVALAEQTSAK
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
What are the official names of this protein?
Anthranilate synthase component 1, AS, ASI.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.
Protein: NAR1_CANGA
Sequence: MSALLSEDYLNDYISPALACTKPTEIKKEKFVTEDGEFQVGVEPQELEKVTISLSDCLACSGCITSSEEIMLSQQSHSVFLDAWRELGFDKCGSAGDAQCTNKLVVSISPHCRASMARYYGVDVDAADYAILRVFKEVFHATSVIGDGAGRLLSVKRVVEELMERRKASQGTALSSICPGFLIYTEKTKPKLVPMLLNVKSAQQVTGALFKEIALEEGYDVDTSLKDGKRTNVQYHLTIVPCFDKKLEASRPDGEGEVNCVITPREVLAMLGEMGVSFRKYLGDWASLDKQLQQSQLGMLRAEMSPAGWDPLLHWSIPANGDGYSDGYAYQYACTVRDAHVASGCAAQVVSVPGKNADVLEYRVVEPSSEGGKVIARACVLSGFRNIQNLCRKLDPSGHKKRSVRRVAALRSRGRKDSSSEDSTGTPSAISNALGGTANPAECDYVEVSACPSGSINGGGLLMELAPEREEMGETPLPSSTIGGNARRRQQQLQELQAMYKAQIRITDETPTSLPPAALPPLPPQYTMQYTFYIQEEDPAKPDIVTVGNTW
What is the function of this protein?
Component of the cytosolic Fe/S protein assembly machinery.  Required for maturation of extramitochondrial Fe/S proteins.  May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NAR1, Nuclear architecture-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: MURI_STRPC
Sequence: MDTRPIGFLDSGVGGLTVVCELIRQLPHEKIVYIGDSARAPYGPRPKKQIKEYTWELVNFLLTQNVKMIVFACNTATAVAWEEVKAALDIPVLGVVLPGASAAIKSTTKGQVGVIGTPMTVASDIYRKKIQLLAPSIQVRSLACPKFVPIVESNEMCSSIAKKIVYDSLAPLVGKIDTLVLGCTHYPLLRPIIQNVMGPSVKLIDSGAECVRDISVLLNYFDINGNYHQKAVKHRFFTTANPEIFQEIASIWLKQKINVEHVTL
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: GBRL1_PONAB
Sequence: MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNREEDYFLYVAYSDESVYGK
What is the function of this protein?
Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor.  Involved in formation of autophagosomal vacuoles.  While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.  Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.
What are the official names of this protein?
Gamma-aminobutyric acid receptor-associated protein-like 1, GABA(A) receptor-associated protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm, cytoskeleton. Endoplasmic reticulum. Golgi apparatus.
Protein: QUEC_CHLPM
Sequence: MKAVVLLSGGMDSLVTTAIAHNEGLQLAAMHVNYGQRTWQRELESFRSIAGHYGIGELLEVNADFLGTIGGSSLTDHTMAVSGADLQGTAIPTSYVPFRNACFLSMAVSWAEVIGAQKLYIGAVEEDSSGYPDCRKVFYDAFNKVIELGTKPETGIEILTPLIAMQKAGIVEKGMELDAPFHYSWSCYKSEGKACGVCDSCARRLRAFELVGVRDPIDYDVRPQYIH
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: BOA8_BOTFB
Sequence: MFNSTMDIDPHLRVRERMNQRKQSRSIYHSINDKKKTISRPNPSINIAIMTQTSQMKVVIVGGSIAGLTLAHCLSRYGIDYIILERRHDIAPQVGASTWDENGRLLSETDAPILTGKRLGYTITFLERETLLEILYRHLPDKSKVLTGKYVRSIEQDSKEAVVICEDGSRYSGDVIAGADGIHSTIRSEMRRQIAKEGTTKDLEALKRDEIALSAEYSCLFGISKPIPGLEIGHTHRSSGKGASTLLFGGVDGKLYWFLFTKNEERTFGDGIPRYKKGDETNHVAKYMHHHVSGNILLSEVWKNRIVANFVTIEEMENEHWNWNRVACLGDSIHKMTPNLGQGANCAIESAAEMANSLAKALRDDGSKPAIEDINSALSLYHQKRNVRANLIVKAANKFTRVEALATTGDWVASMFIIPRLGDILADRGAKVQVGATKLDCLPMPKRALEGTMPWSTNSGIGKEENRKRRAQLALPLILIALWFFWKKTPEPKGFPVTKTFSEVKLDMLSSIANAIPFATIWTIESYRRGNALTVANIFPTAFLLLAQKLGIELVAPIYFFFHYVQSPQENFAALDNRLTNIAFAKILPLAILSIFLGPSYCIWSSIELESAQWIYDNAWYWYPVYLTMFLRILKFIVKDTTRLNRIYKPTADLSYLRISYSISILICAAFYLYGSLSSSTSIAFLTQELQPPIQPIQAILGAFSELWAAKQTSLYGAAFYWTFLHFADLKFVGKSKQSWLLILTIXLSSTFLAGPGVGLIVMWAWREEIMAKKHVVPE
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster B that mediates the biosynthesis of botcinic acid and its botcinin derivatives, acetate-derived polyketides that contribute to virulence when combined with the sesquiterpene botrydial (PubMed:21722295).  Botcinic acid and its derivatives have been shown to induce chlorosis and necrosis during host plant infection, but also have antifungal activities (PubMed:21722295).  Two polyketide synthases, BOA6 and BOA9, are involved in the biosynthesis of botcinins.  BOA6 mediates the formation of the per-methylated tetraketide core by condensation of four units of malonyl-CoA with one unit of acetyl-CoA, which would be methylated in activated methylene groups to yield a bicyclic acid intermediate that could then either be converted to botrylactone derivatives or lose the starter acetate unit through a retro-Claisen type C-C bond cleavage to yield botcinin derivatives (PubMed:23203902).  The second polyketide synthase, BOA9, is probably required for the biosynthesis of the tetraketide side chain of botcinins (Probable).  The methyltransferase (MT) domain within BOA6 is probably responsible for the incorporation of four methyl groups (Probable).  The trans-enoyl reductase BOA5 might take over the enoyl reductase function of BOA6 that misses an ER domain (Probable).  The monooxygenases BOA2, BOA3 and BOA4 might be involved in further hydroxylations at C4, C5 and C8, whereas BOA7, close to BOA9, could potentially be involved in the hydroxylation at C4 in the side chain of botcinins (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase BOA8, Botcinic acid biosynthesis cluster B protein 8.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATO1_OMPOL
Sequence: MTTRTSGYVREEFVAPPEHTFTLPDSTIVRSIEQDGTVEVFLAQSSAPIAIFSPHARTLRVSPHGIVNDDRAVSSPAPCFTTAEPALSTEDAWAALYALWMRRTEKDVLPLVLDSRTESLKPYLVQTGLAFSPPDAQSEFELLVVRAAFWQGAGAPVNRHWLQNMVPDPSTSIAPFPAITSFTRTEHVLTTHPLRPPKPAPGAVIYSRYIHTVNQQLTLTHIDANNLEHFAAYSRWQNSERVNIGWRERGPDEKHRKYLADRLADLHSMGVIIAWDGQLAGYGEVCWVKEDPMGTYVGGLGDYDQGIHILIGEEKFRGRHRFTAVMTSLYHACFLREPRTEVVVSEPRADLPIVPRLIAYLPQELNREFELPHKRAVYTVVRRERFFQAAMLY
What is the function of this protein?
L-ornithine N(5)-monooxygenase; part of the siderophore biosynthetic pathway (PubMed:16019163).  Omphalotus olearius produces ferrichrome A, but no other siderophore has been detected (PubMed:16019163).  Ferrichrome A consists of a hexapeptide ring made up of one glycine, two serine, and three N(5)-hydroxyornithine amino acid residues, the latter acylated by trans-(alpha-methyl)-glutaconic acid residues (PubMed:16019163).  The biosynthesis of ferrichrome A depends on the hydroxylation of ornithine to N(5)-hydroxyornithine, catalyzed by the monooxygenase omo1 (PubMed:16019163).  The second step, the acylation of N(5)-hydroxy-L-ornithine is probably catalyzed by the N-acyltransferase ato1 (PubMed:16019163).  Finally, assembly of ferrichrome A is catalyzed by the nonribosomal peptide synthase (NRPS) fso1 (PubMed:16019163).
What are the official names of this protein?
Acyltransferase ato1, Ferrichrome A biosynthesis cluster protein ato1.
What is the protein family that this protein belongs to?
Belongs to the lysine N-acyltransferase mbtK family.
Protein: HEM2_CHLPN
Sequence: MSSLTLSRRPRRNRKTAAIRDLLAETHLSPKDLIAPFFVKYGNNIKEEIPSLPGVFRWSLDLLLKEIERLCTYGLRAVMLFPIIPDDLKDAYGSYSSNPKNILCHSIHEIKNAFPHLCLISDIALDPYTTHGHDGIFLNGEVLNDESVRIFGNIATLHAEMGADIVAPSDMMDGRIGYIRSKLDQSGYSKTSIMSYSVKYASCLYSPFRDALSSHVTSGDKKQYQMNPKNVLEALLESSLDEEEGADILMVKPAGLYLDVIYRIRQNTCLPLAAYQVSGEYAMILSAFQQGWLDKETLFHESLIAIKRAGADMIISYSAPFILELLHQGFEF
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: PPD1B_XENLA
Sequence: MATESILITTLPMDFNSQMNNVTIGLNDNETLCENWREIHHLVFHLANACFAAGLVIPSTLNLHMIFLRGMLCLGCTFFIIWAVLFRCALDIMIWNATFLIINFMHFVYLVYKKRPIKVKNDLKDIYHRMFEPLHVSPELFNRLTGQFCEMKTLAKGQTYAVEDKTSVDDRLSLLLMGIMKVSYRGHFLHTISANAYIDSPEFRSTEMNRGETFQVTITADENCVFLCWSRERLTYFLESEPFLYEIFKYLIGKDITTKLYSLNDPTLGKKKKLDTQPSLCSQLSVMEMRNSLASTSDHEDGLQNFLRGTSTTSSQRHNQQEFYNAYGVGPLSHAVFC
What is the function of this protein?
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity.  Plays a role in vamp3-mediated vesicular transport and recycling of different receptor molecules.  May be involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells.  May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner.  May be involved in epithelial movement during corneal sheet formation and regeneration.  May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity.  May also be involved in striated muscle regeneration and in the regulation of cell spreading (By similarity).
What are the official names of this protein?
Blood vessel epicardial substance-B, Popeye domain-containing protein 1-B, Popeye protein 1-B, Xpop-1-B.
What is the protein family that this protein belongs to?
Belongs to the popeye family.
What are the subcellular locations of this protein?
Lateral cell membrane. Cell junction, tight junction. Membrane; Multi- pass membrane protein. Note=Detected at points of cell- cell contact in confluent epithelial sheets. Colocalizes with components of the adherens and tight junctions (By similarity).
Protein: CARA_PSEPK
Sequence: MTKPAILALADGSIFRGEAIGADGQTVGEVVFNTAMTGYQEILTDPSYAQQIVTLTYPHIGNTGTTPEDAESSRVWSAGLVIRDLPLLASNWRNTQSLPEYLKANNVVAIAGIDTRRLTRILREKGAQNGCILAGDNISEEAAIAAARGFPGLKGMDLAKVVSTKERYEWRSSVWELKTDSHPTIDAADLPYHVVAFDYGVKLNILRMLVARGCRVTVVPAQTPASEVLALNPDGVFLSNGPGDPEPCDYAIQAIKEILETEIPVFGICLGHQLLALASGAKTVKMGHGHHGANHPVQDLDTGVVMITSQNHGFAVDEATLPGNVRAIHKSLFDGTLQGIERTDKSAFSFQGHPEASPGPTDVAPLFDRFTDAMAKRR
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.