PharMolix/UniProtQA huggingface dataset:
Protein: GTR5_HORSE
Sequence: MEQQDPIKKEGRLTPVLALATLIAAFGSSFQYGYNVAAVNSPAELMKAFYNETHYSRFSEYISEFSLTLLWSISVSMFPFGGFVGSLMVGPLVNRLGRKGTLLFNNIFSIVPAILMGTSKTARSYEMIILSRLLVGICAGLSSNVVPMYLGELSPKNLRGALGVVPQLFITVGILVAQIVGLRSLLATEEGWPILLGLTAIPAALQLLLLPFFPESPRYLLIQKKDAAAAKNALKRLRGWDDVDAEMEEIQLEDEAEKAAGIISVLTMFRMRSLRWQVISIIILMGGQQLSGVNAIYYYADQIYLSAGVKDQDVQYVTVGTGAVNVLMTICAVFVVEYLGRRALLLLGFSVCFIACCVLTVALALQDRVSWMPYISIVCVISYVIGHALGPSPIPALLITEVFLQSSRSAAYMVGGTVHWLSNFAVGLVFPFIQVGLGAYSFIIFAVICLLTTIYIFLIVPETKGKTFVEINHIFTKMNKVSDVHPAKDELKDIPLSAVEL
What is the function of this protein?
Functions as a fructose transporter that has only low activity with other monosaccharides.  Can mediate the uptake of deoxyglucose, but with low efficiency.  Essential for fructose uptake in the small intestine.  Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose.  Required for the development of high blood pressure in response to high dietary fructose intake.
What are the official names of this protein?
Solute carrier family 2, facilitated glucose transporter member 5, Fructose transporter, Glucose transporter type 5, small intestine, GLUT-5.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.
Protein: DUS14_BOVIN
Sequence: MSSRGHSTLPRTLMAPRMISEGDLGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGIVPDVYEKESRHLLPYWGI
What is the function of this protein?
Involved in the inactivation of MAP kinases.  Dephosphorylates ERK, JNK and p38 MAP-kinases (By similarity).
What are the official names of this protein?
Dual specificity protein phosphatase 14.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Protein: RRF_NOVAD
Sequence: MAKYDKADLERRMKGAVESLRGDLSGLRTGRANTALLDPIVVEVYGSHMPLAQVATVSAPEPRLLSVQVWDKSNVTPVEKAIRSAGLGLNPISDGNTLRLPIPDLTEERRKELAKLASKYAENARIAIRNVRRDGMDALKADESKKEISEDERKRAETDLQKLTDDIIKQADEAAAAKEKEILGK
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2687_STAAM
Sequence: MTNFTFDGAHSSLEFQIKHLMVSKVKGSFDQFDVAVEGDINDFSTLKATATIIPSSINTKNEARDNHLKSGDFFGTDEFDKITFETKSVTENKVVGDLTIKGITNEETFDVEFNGVSKNPMDGSQVTGVIVTGTINRENYGINFNQALETGGVMLGKDVKFEASAEFSISE
What are the official names of this protein?
UPF0312 protein SAV2687.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family.
Protein: GUAAA_METB6
Sequence: MLPICVVNNYGQFNHLIHRALRDLDIDAVLIPNTTPREEIASQYRGIILGGGPDIARAGVCAEYLDLGIPVLGICLGLHIIARKFGGVVHPGKSGGYGSVEVTIREHDDILSGYPDIIPVWASHADEVCRIPEGFTLLASSGICEVEAVACPRKRIYGLQWHPEVSHTVGGKRVYENFDAICTE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: KHSE_BLOPB
Sequence: MVRVYAPASIANIGVGFDTLGMAIAPINGSLLGDCISIEHANAFSLRSTGFFHSQLPIQLEENIVFQCWRKFCEILGQTYFLSIKLEKNIPVASGLGSSACSIVAVLVAMNYHCGCPLNTDQLLMLMGEMEGKISGSIHFDNVSPCFLGGMRLILQNCNIVNQVIPSFDDWLWIVAYPGIKISTAVSRSVLPNKYDREDCINHSQYLSGFVHACHTKQEYLAIRCMKDIIAEPYRSRLFPIELSCIRHNIMKRGAISCGISGSGPTVFVLCNNHDVIGDISDWLSRFYLQNNSGFIRICSLDNLGARIMVNN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_SALCH
Sequence: MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RL15_BACCR
Sequence: MKLHELKPAEGSRKVRNRVGRGIGSGNGKTAGKGHKGQNARSGGGVRLGFEGGQTPLFRRLPKRGFTNINRKEFAIVNLSTLNRFEDGTEVTPELLLETGVISKLNDGVKVLASGAVEKKLTVKAHKFSSSAKEAIEAAGGSVEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: NU4LM_NASLA
Sequence: MPIIYTNIVLAFMISLLGMLIYRSHLMSSLLCLEGMMLSLFMMSTLMALNMHFPLANIVPIALLVFAACEAAVGLALLISISNTYGLDHIHNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: P3F4B_XENLA
Sequence: MATAASNPYSILSSSSLVHADSAVMQQGSPFRNPQKLLQSDYLQGIPSNGHPLGHHWVTSLSDANPWSSLASSPLDQQDIKPGREDLQLGAIIHHRSPHVSHHSPHNNHPNTWGASPVHNSSGQPINVYSQPGFTVSGMLDHGGLTPPPPSGTTQSLHPVLREATDHGDLGSHHCHDHSDEETPTSDELEQFAKLFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAALEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDPQQHEIYSHSVKTDTSCNEL
What is the function of this protein?
Transcriptional activator.  Induces neural-specific gene expression to act as a key regulator of neural differentiation (By similarity).
What are the official names of this protein?
POU domain, class 3, transcription factor 4-B.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIE2_STREX
Sequence: MAAMALTASLAGALAGTASAAQQAQPSPSQKDTPAARAVAAADQAVDSGLDSLVNSSQEQYERRLVTPWVKDLYSVSYERSYRGLPVVGGDAVVLADGTGKVRALQSASSVRIDVSTQASVSAKDAESTSRAKLVSVDKVESSRLVVRLKDDKPVLAWETVLSGRTKTAPSKLHVFVDARTGAFVDSYDEVVAGTGNSKWNGPGPVTIDTTNSGSTYTLRDPVRTGLSCADYSTGTVFSKSSDSWGTGNPTSKETGCVDLMFAAQKQWDMLSQWLGRNGVSGNGRSFPAKVGLSDLNAYWDGSSVTIGRNSAGEWIAGIDVVAHEYGHAIDSNTPGGTSGQESGLGEATGDIFGALTEAFANEPAPYDTPDYTVGEVINLQGRGPIRNMYNPPAVNNDPACYSSAIPGTEVHAAAGPLNHWFYLLAEGTSPGGGKPNSSTCNGTSLTGVGVQNAGKIFYGGMLLKTSSMSYKKYRTATLSSAKSLDATCDLFNKTKAAWDGISVPAQTADPTCTPSGQNNDFSMSLSPSSGTVQQGASVTTTVGTTVTTGNAQSVTLTASGLPAGVSASFNPATVQSGQSSVLTLTATANAAPGASTIVVKGQGASLSHTVDYALNVGGTQPGNDPPDIDVANVQAHLTQFNTIASQNGGHRRAGSAGYTQSLAYVKGKLQAAGYTVTEQNCTSCTYPSNNLIADWPGGPADQTVMFGAHLDGVSAGPGINDNGSGSATLLENALVLAQKNPTMTKHVRFAWWTDEEQGLNGSEFYVNQLSSAQRSAIKGYYNFDMVGSTNGGYFINNVNSTTAAPLKAYWTSLNLAPEENTEGQGRSDDYSFQQAGIPTSGYAAGASARKTSAQATKWGGTANAAYDPCYHSSCDTTNNINATVLNRSADGVAYAVWKQAVGGETPAQDFSVAVSPSAGSAAPGGSTSATVNTATVSGAAQTVALSVSGAPAGVTATLSPTSVQSGSSSALSVQVGASTAPGTYTLTVTGSGTVSHTSTYSLTVTGGGSCTPRQLVTNGGFESGSSPWSATAGQTLETLSNLNANSGYAEKSYDLSQFAGQTVTLKFTGTEDQSLQTSFVVDDVTVQVS
What is the function of this protein?
A leucine-specific metalloprotease that plays a role in controlling the amount of leupeptin during colony development.  Degrades leupeptin into three components, acetyl-leucine, leucine and argininal (By similarity).
What are the official names of this protein?
Leupeptin-inactivating enzyme 2, LIE2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28A subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FUCI_STRZJ
Sequence: MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLKYPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIPHAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEANDTDIPEDVKEKLLRYARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDPEEFERAMVWVKEHIKEGVDRNREDLILSKEEKEKQWEFVIKMFMIGRDLMVGNPRLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFATENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVERVTGYTLEGRAAAGFLHLINSGSCTLDGTGQATRDGKPVMKPFWELDESEVQAMLENTDFPPANREYFRGGGFSTRFLTKGDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDSGWPTTWFAPRLTGKGAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSLFGTEDLESADYRACQLLGPLHK
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_BRUO2
Sequence: MTLVGNFSPLVLVGDSDRVEAETVGAYLDGWAGHDKVRLATANAIKAILSGAGRLVGRIARGYLPGDPGKLVGVNSDQDQQKSIDVGSHNLFVELLIAAGVASILSEEADLPVAGKADGLVAVAIDPLDGSGNVGLGAPLGTIFSIFPADVEEPFLQPGNRQIAAGYVSYGNSVDLGFSVGEGVIFATLDPVSGQFHITRRNVKLPERTSDLAFNASVQRHLSAGMQAYVNDAFLGKDGPRGRNFNMRWLGAAVGDMHRIMQRGGLFFYVNDSRPGYEKGRLRLVYEANPIAFLAREAGSKATDGSRPILDIVPQTYHERSALVFGVAEEVDILGEYFVK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOB_STAHJ
Sequence: MTTPFKRVHLIVMDSVGIGEAPDAAAFNDEGSHTLKHTLEGFNQTLPNLEKLGLGNIEELPVVNKVEQPGAFYTKLSEASVGKDTMTGHWEIMGLNIMQPFKVYPNGFPDELIQEIEEMTGRKVVANKPASGTAIIDELGEHQMKTGDLIVYTSADPVLQIAAHEDIIPLEELYDICEKVRELTKDPKYLIGRVIARPYVGEPGNFTRTSNRHDYALKPFGKTVMNTLKDNNYDVIAIGKINDIYDGEGVTEAIRTKNNMDGMDQLINVVKKDFNGISFLNLVDFDALYGHRRDKEGYAQAIKDFDERLPELIDNLQEDDLVIITADHGNDPIADGTDHTREYIPVLMFSPKIDKYHELSGDSTFSSIGATIADNFNVELPEFGKSYLNEMGVEH
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUB8_GIBF5
Sequence: MGSISHLPVYGHRLLPVVIDEIARDEPDRVLFYTPRNGQPSQGYDKVTTKIFANSINRLCGWLDSQLGSPTVSKTIAYIGQNDLRYFIMMIASTKLGHRLLLSSPRNSVEGHVSLIKQSGCEFWIASSGLDHHGFLQDLQIPSVEAPELSQLLDPTPLKPYVYQKSWNEGKSDILALLHTSGSTGLPKLVPVYLETAATVDGFHLMELTNGKRPTGVEWTGTRQLCAMPLFHVAGICLGLYSAVFFNWTVVLPSVGPIMQHVIEDALDHITLDSAFISPSVLQDISKSPRVLEKLSKLKFITSAGGPIPQSVGDLIHPRVPIMQTMGMTEGQWLASVVTHPDEWAYYYFHPRTGVEMRPYSEDLSELVFVQNPKLTATQPVFKTFPELDIWETKDLYSRHPKHPSLWKYEMRRDDLVILSNGEKFNPLAAEGKLISHPWIAAAYLTGRGRFQTAALLYPDETNLDKSDDTIIDNVWPTFEEVNRSLPAFAQIHRDFVKIVRTPFPRTPKGTLARNETEKAFTADINAIYDRSTHGKPSVHINGTTEVVVRSGIREAIEAVSGLVDLKDDDNIFTRGFDSLHVIRLAGLLSSAFDQPIEVEVGTIYTNPTVSQLARSVWSHLEHGPQDKIHHSEATREMLAKYAQAFEPPREAKEHIVITGTTGEIGSYLLDVLCNNDKVAKIWCLNRSADAFQRQVDSAKSKGLSSTWQSKAKFVRYDVAADNLGLSQDDLQEIKNQATAIIHNAWEVNFNLPLSSFEPQFVGLQSLVDICREARHKLRFFFISSISAAMNWPSDLLGPVPEASIPRFDAPINGYGSSKLVAEHLLSKAARSGVLSLSVLRVGQVAGPVKTLGEGSIWTRRDWVPAIIDASVHLRALPLDLGTASILDWIPIDLLTEVIGQLVVPVNAVVGQENYYNLLNPRTPSWIDALPGLKAHLEVSFSDKFEIIPLHEWIGRLRGAEKTIVKEVSEGSSETARRAQSGLKLLAFFEMLASGEEGSRGLEWSKGNTLAQSSILACMEPVSSAWFGTWLTQWGY
What is the function of this protein?
Non-canonical non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:26662839).  L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (PubMed:26662839).  The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (PubMed:26662839).  FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (PubMed:26662839).  Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (PubMed:26662839).  Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (PubMed:26662839).
What are the official names of this protein?
Non-canonical non-ribosomal peptide synthetase FUB8, Fusaric acid biosynthesis protein 8.
Protein: YQXD_BACSU
Sequence: MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVASFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVMSERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDEGILH
What are the official names of this protein?
UPF0178 protein YqxD, p23.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: ARIR_ECOL5
Sequence: MLEDTTIHNAISDKALSSYFRSSGNLLEEESAVLGQAVTNLMLSGDNVNNKNIILSLIHSLETTSDILKADVIRKTLEIVLRYTADDM
What is the function of this protein?
Regulates expression of genes involved in acid-resistance and biofilm formation.  May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition (By similarity).
What are the official names of this protein?
Regulatory protein AriR.
What is the protein family that this protein belongs to?
Belongs to the AriR family.
Protein: RL14_BORA1
Sequence: MIQMQTTLDVADNTGARAVMCIKVLGGSKRRYAGIGDIIKVSVKDAAPRGRVKKGEIYNAVVVRTAKGVRRKDGSLIRFGGNAAVLLNAKLEPIGTRIFGPVTRELRTEKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: EV45_EHV1D
Sequence: MAGDPTAAMEDYKLLQLETATVDAQAPPLPTKTVPVFAPPLSTPPQPNELVYTKRRRTKRKAKCRCLFFTMGMFALGVLMTTAILVSTFILTVPIGALRTAPCPAETFGLGDECVRPVLLNASSNTRNISGVGAVCEEYSEMAASNGTAGLIMSLLDCLNVGDSESVMNKLNLDDTQLAYCNVPSFAECYTKGFGVCYAARPLSPLGELIYKARQALRLDHIIPFPR
What are the official names of this protein?
Envelope protein UL45 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HHV-1 UL45 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein.
Protein: FEMX_STAEQ
Sequence: MEKMNITNQQHDAFVKSHPNGDLLQLSKWADTKKLTGWYSRRIAVGENGQIKGVGQLLFKKIPKLPYTLCYVSRGFVADYNNKEVLEALLSYAKEVAKDEKSYAIKIDPDVEVDKGAEALKNLRELGFKHKGFKEGLSKDYIQPRMTMITPIDKTDDELVQSFERRNRSKVRLALKRGTKVERSNREGLKIFANLMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLEPKPVLDTVNQDLEAQLAEKEKLQSKKQDKKTLNKLNDIDNKIKKTNELKSDLTELEKSEPEGIYLSGALLMFAGNKSYYLYGASSNDYRDFLPNHHMQFEMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKRVWGTYLSEKIGEFDYVLNQPLYHLVEKVKPRLTKAKIKISRKLKGK
What is the function of this protein?
Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor.
What are the official names of this protein?
Lipid II:glycine glycyltransferase, Factor essential for expression of methicillin resistance X.
What is the protein family that this protein belongs to?
Belongs to the FemABX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MELN_APICE
Sequence: MKFLVNVALVFMVVYISYIYAAPEPEPAPEPEAEADAEADPEAGIGAVLKVLTTGLPALINWIKRKRQQG
What is the function of this protein?
Main toxin of bee venom with strong hemolytic activity and antimicrobial activity.  It has enhancing effects on bee venom phospholipase A2 activity.  This amphipathic toxin binds to negatively charged membrane surface and forms pore by inserting into lipid bilayers inducing the leakage of ions and molecules and the enhancement of permeability that ultimately leads to cell lysis.  It acts as a voltage-gated pore with higher selectivity for anions over cations.  The ion conductance has been shown to be voltage-dependent.  Self-association of melittin in membranes is promoted by high ionic strength, but not by the presence of negatively charged lipids.  In vivo, intradermal injection into healthy human volunteers produce sharp pain sensation and an inflammatory response.  It produces pain by activating primary nociceptor cells directly and indirectly due to its ability to activate plasma membrane phospholipase A2 and its pore-forming activity (By similarity).  Shows lower cytotoxicity when tested on E. coli and cancer cell lines than melittin, as well as lower anti-inflammatory properties and lower properties to interact to small unilamellar liposomes (PubMed:24512991).
What are the official names of this protein?
Melittin-N, MEL-N, MLT.
What is the protein family that this protein belongs to?
Belongs to the melittin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Alpha-helical peptides form toroidal pores in the prey.
Protein: NCAP_CVMA5
Sequence: MSFVPGQENAGGRSSSVNRAGNGILKKTTWADQTERGPNNQNRGRRNQPKQTATTQPNSGSVVPHYSWFSGITQFQKGKEFQFAEGQGVPIANGIPASEQKGYWYRHNRRSFKTPDGQQKQLLPRWYFYYLGTGPHAGASYGDSIEGVFWVANSQADTNTRSDIVERDPSSHEAIPTRFAPGTVLPQGFYVEGSGRSAPASRSGSRSQSRGPNNRARSSSNQRQPASTVKPDMAEEIAALVLAKLGKDAGQPKQVTKQSAKEVRQKILNKPRQKRTPNKQCPVQQCFGKRGPNQNFGGSEMLKLGTSDPQFPILAELAPTVGAFFFGSKLELVKKNSGGADEPTKDVYELQYSGAVRFDSTLPGFETIMKVLNENLNAYQKDGGADVVSPKPQRKGRRQAQEKKDEVDNVSVAKPKSSVQRNVSRELTPEDRSLLAQILDDGVVPDGLEDDSNV
What is the function of this protein?
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M.  Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the betacoronavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Protein: RS6_GEOSM
Sequence: MSRMYETIYIVQPDLGDEEIKALSTKVQDVVAGMNGDFKRLEDWGTRKLAYPINKNPRGRYFYLRFDGDSGLIAELERRLRLDDKVIRYQSVKLETEVVAPAAAPVKSAEEGTEEVAAEAATEAPAETTTTVEV
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: HMOC_DROME
Sequence: MAAGFLKSGDLGPHPHSYGGPHPHHSVPHGPLPPGMPMPSLGPFGLPHGLEAVGFSQGMWGVNTRKQRRERTTFTRAQLDVLEALFGKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQLQQQQQSNSLSSSKNASGGGSGNSCSSSSANSRSNSNNNGSSSNNNTQSSGGNNSNKSSQKQGNSQSSQQGGGSSGGNNSNNNSAAAAASAAAAVAAAQSIKTHHSSFLSAAAAAASGGTNQSANNNSNNNNQGNSTPNSSSSGGGGGSQAGGHLSAAAAAAALNVTAAHQNSSPLLPTPATSVSPVSIVCKKEHLSGGYGSSVGGGGGGGGASSGGLNLGVGVGVGVGVGVGVSQDLLRSPYDQLKDAGGDIGAGVHHHHSIYGSAAGSNPRLLQPGGNITPMDSSSSITTPSPPITPMSPQSAAAAAHAAQSAQSAHHSAAHSAAYMSNHDSYNFWHNQYQQYPNNYAQAPSYYSQMEYFSNQNQVNYNMGHSGYTASNFGLSPSPSFTGTVSAQAFSQNSLDYMSPQDKYANMV
What is the function of this protein?
Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks.  Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli.  Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors.
What are the official names of this protein?
Homeotic protein ocelliless, Protein orthodenticle.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RHLB_VIBCH
Sequence: MKKTHITEHKFADFGLQPQVIDGLEKKGFVYCTPIQALALPVLLSGQDIAGQAQTGTGKTLAFLTATFNHLLTTPAAEGRAETQPRAIIMAPTRELAIQIFNDAEPLLASTGLKAALAYGGESYDKQLAKLQSGVDILIGTTGRIIDFYKQRVFNLNHIQAVVLDEADRMFDLGFIKDIRFLFRRMPEPKDRLNMLFSATLSYRVQELAFEHMNNPEHVVVEPEQKTGHRIQEELFYPSNEHKMALLQTLIEEEWPDRAIIFANTKHRCEQIWAHLAADNHRVGLLTGDVPQKKRERILEQFTQGDVDILVATDVAARGLHIPQVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISFACEEYAINLPAIESYIEHAIPTSDYDPSALLTDLPAPLSLRSSPQQRRTNTAGSRNSNNGGNRKPQQRRPRAPRPKKEA
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_LACH4
Sequence: MKMTKKVLVAGFMGAMGQKAVNLVNNMSGFEVVAGLSPIAEDNPEQYHLPASAKIFKNLTEIPDNLADFWIDFTTPKAVYENVKFALQHHIRPVVGTTGMSDEQEAELIVLSKKEKVGGLIAPNFGMSAVLLMKFAKEAAKYFPDVEIIEMHHADKKDAPSGTALATAKMIAENRPEHQTAPDEVETLKNVRGGDYQGIKIHSVRLPCYIAHEQVLFGGPGEALTIRQDSFDRGSFMNGVKVALEKVDQLDELVIGLENIL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_STRU0
Sequence: MAVTGIVAEFNPFHYGHKYLLEQAEGLKIVAMSGNFVQRGEPAIVDKWTRAQMALENGADIVVELPFQVAVQSADYFAQGAVDILSTMGADTLAFGTEEDLDYSEIARIYEEKAEQMTAFLETLDDSLSYPQKTQKMWESFTGIDFSGNTPNHILALAYAKASAGKNLRLQPIKRQGAAYHSQEKNQMMASATAIRKHISDRTFVLQSTPSSELLLMAPQVNWENYFDLVRYHILSQEQLDHVFQVNQEIANRLKSAIVHVHSIEELVDKVSTKRYTKARVRRILTYILVNARENNLPNGVHVLGFTEKGQEHLKKMKKSISIVSRIGAVPWDQQTQTADRIYQLGHSDIKEQNFGRSPIRIEKLG
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.