PharMolix/UniProtQA huggingface dataset:
Protein: ATPG_MALP2
Sequence: MASLNEIKKRIKIIESTSKITNAMKLVSSAKLKKQKELFLNESIYYKKFYDLFTYIKSNSDSEILSLKKSEEGKTIWLAFFSSMGLCGSFNLNIVKELQKHIKSNDEIWLIGKKGKNLIKSKGIEAEISLDLELDDKDINFDLFHIIAENLLAKYKNDYNIKSIKVIYSKFVNSLSFTPSVFSLLPLDKAIEKPRLDKPNNGADFSIQPNANDVFESILIDYLATCIHGAIVESKVCENASRRNAMDSATKNANELIKNYKLEFNRKRQSEITQEITEIVSGAKGE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RRT5_CANGA
Sequence: MSVSRIYIANVSYSSSEEDLREFLKDFNFSSVLIPCHTVRRFRRNEARSFGIAYVDFTSSEEAVRAVEELNGKEFGGRVLRVRTHNPYQPPKPIKERFGTKLQQLKKFAKYEDTAASGERAPTDAQDHPDQPQEGHMSPDVVLVNGTTDEEQQLANVINDPVTNADAPGTEQNISKEKAISEDTVYCAFLPKETTDNDLRNYFTDYGSREIWIFRTKNVSNSRFRFRNRNHTAALVTLSTELPLNKVIEELLGKKLLGTKISIKPAYIYKINEVKKIAEQSHMLATEYRHQNGNSDVVIGTPNEALLNSTQVASQIIGSNPEIEVSNQNSSSIANVAETNGNVGDTPITKLDSRNNIKIVNIGNPQDKTKKNQPNDNKELNKIDLETKNDSLHLESICDPIISIDMSGMTKQSVGSNKKKNKKKKSARGKEVRKLSVSNTTTQ
What is the function of this protein?
May be involved in the modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription protein 5.
What is the protein family that this protein belongs to?
Belongs to the RRT5 family.
Protein: RL6_MYCS2
Sequence: MSRIGKQPVPVPSGVDVTINGQNLSVKGPKGTLTLDVAEPISVSRAEDGAIVVTRPDDERRSRSLHGLSRTLIANLVTGVTEGYTQKMEIFGVGYRVQLKGQNLEFALGYSHPVLIEAPEGITFAVESPTKFSVSGIDKQKVGQISAVIRRLRRPDPYKGKGVRYEGEQIRRKVGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PTH_MYCS5
Sequence: MKLIVGLGNPGDKYKFTRHNVGFLVIDLICQKLKITLDKEKTHGSYAKFEDFIIAKPNTYMNLSGNFVLELANFFKIAPDDILVIHDEKDFELGKSAIKIGGSGGSHNGVLDVINKLNTQNFKRLKIGIGQNQEMALKDYVLQRFSLEEFSVLEPVLNQAADVCIQYSFNDIHYLMNKYNQKKKNGN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL419_YEAST
Sequence: MAKKTKNNSKSSTPVNDVPTTAGKKKAKGKKGQEPEPEDDKRAKQQSNRAKVTSTASWTGKLPHTILHETCQKRKWNKVEYDMKKIGDKGFIAIAVLSFTDPKTKETLTARMNDPTYDKASGKGLVIPQETPIEARHMASTIALYRIAYNTNLHMMLPPNHRKTWYALDDFRKDNLKTDEKRINKLFDLDPFKTMVEDRKLKAQREKEQVAQNNQAQKEQVARTILSSHGGISSSGKDRQERKVASHKNSHNPSLVRFPKKVWENSIFVDLDESSRQLIETSLKEKIDWQAKKISHKNETIAENREDLKAKLLTLQFRPKHVEEAMLYKDPLSFLLFNLPEDDLPPFFHKKKGDTKNKVEITNLPLSTRMIVERLTEIGVSSDEALLALQQNDMNENEAAGFLTREILPTLNSNTNEPVSETESIECWNQELESLESIYEGCVMDAKEDSHYTLNLIEKLKIKLKVYRTKNYPASLPGIVVSTFDKNYKLPDYIKKQILTRLLHYLQEGNLIGDMLVYHIYEWLKENISKIIDNPGPLIPDSDSKGAINKRNISNGKRSINNSSSRKFTKTTISEDTLSVLREEYTKRIKSSEYKSMQLVREQLPAWKKQKVIIDIINKNEVVLITGETGSGKSTQVVQFILDFLQKEKGDFGKTKIVCTQPRRISAIGLAERVSDERCVTCGEEVGYVIRGVNKTKASTRIKFMTTGVLVRLLQNARTMLENTIVVIDEVHERSIDTDLIVTLMKNLLHRVRGMKIVLMSATVNVDLFKKFFPGLATCHIEGRTFPITDYFLEDILSDLDFKIKREKALSYDDDSVDERNNDDQYLKPRADSKFFTSGQINYDLLCQVVEYVHKRLKAANDNGSIIVFLPGVGEINKCCNLLANKSNEADFMVLPLHSALTPEDQKRVFKKYHGKRKVVVSTNIAETSITIDDCVATIDTGRAKSMFYNPKDNTTKLIESFISKAEVKQRRGRAGRVREGLSYKLFSKNLYENDMISMPIPEIKRIPLESLYLSVKAMGIKDVKAFLSTALDAPPLPALQKAERILTTIGLVDESDKSLTQLGQFISLMPVMDSKHGKLLIYGILFGCTDISVLLVSILGIGVLPFIGGFENREKIKKLLCKYESRGDLFAVLEIVRDYFKIKDSSIKRKYLRDNLLSYNKINEIKSSTAQYYSILKDVGFLPMDYKVGSISDLNRNERNFDILRAILTGAFYPHIARVQLPDVKYLSTSSGAVEKDPEAKMIKYWIRSEEYQDKLEEYKTKISQETQKVDLEDLPLPATRAFIHPSSVLFSTNSVNLEDAKLLSEVDGPISRQSKIPTVVKYPFVLFTTSQVTNKLYLRDLTPTTTLSLLLFGGAISYDIGGTIHSPGIVVDNWLPIRTWCKNGVLIKELRTQLDEAIRKKLESPDYAKKSQIDNSGADKTLKIVEKIIASEQ
What is the function of this protein?
Probable ATP-binding RNA helicase.
What are the official names of this protein?
Putative ATP-dependent RNA helicase YLR419W.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_GEOSW
Sequence: MASIAVCPGSFDPVTYGHLDIIRRGAKVFDQVYVAVLNNSSKKPLFSVEERIELLREVTRPFPNVIVESFHGLLVDYARSKNASAILRGLRAVSDFEYEMQITSMNRVLDENIETFFMMTNSQYAFLSSSIVKEVAKYNGNISDLVPPVVEEALRKKFASLTSNERNES
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIW_ALKMQ
Sequence: MILQTKHFGEIEINQEEIIRFPDGIPGFDDYTQYIFIENPDKEVPFHWLQAVEDGALAFVITNPFLFKPDYDFEISKNVVEKLSIEDQSDLQVYTIVRVPENIKEMTANLRAPLVINTKNKKGKQLMLDSEVYHTKHYILEEIQKMQEQSNQTSPAAEGGRD
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPCKG_METLZ
Sequence: MLTLPPENRWLFREPFGTVFSDFSMVLPYIEGKIFCTVGDVVTHNALSAGLIPSIGVIDGFTKRSPYLKMPEIQGHILHVTNPAGTITDELIAALRLAMDEIPCVVMVNGEEDLAVLPLTEILPDGAVILYGQPEEGLVICEVNKQLRANAKKLLTYFVSL
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.
Protein: RIMM_STAAR
Sequence: MRVEVGQIVNTHGIKGEIKVKSNSDFTDVRFQPGQVLTVVHNNNDLEYTVKSHRVHKGLHMLTFEGINNINDIEHLKGSSIYQERDHEDIVLEENEFYYSDIIGCTVFDDQETPIGRVINIFETGANDVWVIKESKEYLIPYIADVVKEVDVENKKIIITPMEGLLD
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_NEIMF
Sequence: MTTPKKTAKTSGNEARELADLSEDIGIRFKYPNSERVYLQGSRDDIRVPLREIRQDDTYTAQGAEANPPIPVYDTSGVYGDPAAHIDLKQGLPHIRTAWLNERGDTEILPKLSSEYGIERAHDPKTAHLRFNQITRPRRAKSGGNVTQLHYARRGIITPEMEFVAIRERLKLDELSQKSEYAKLLKQHAGQSFGANIPTHPDQITPEFVRREIAAGRAIIPANINHPELEPMIIGRNFRVKINGNLGNSAVTSSLTEEVEKMVWSLRWGADTIMDLSTGAHIHETREWIIRNAPVPIGTVPIYQALEKTGGIAEDLTWDLFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTADRLTGIVSRGGSIMAKWCLAHHRENFLYTHFDEICEIMKAYDVSFSLGDGLRPGCIADANDESQFAELHTLGELTSKAWKHDVQVMIEGPGHVPLQRVKENMTEELQHCFEAPFYTLGPLVTDIAPGYDHITSGIGAANIGWYGTAMLCYVTPKEHLGLPDKEDVRTGIITYKLAAHAADLAKGWPGAQLRDNALSKARFEFRWRDQFRLSLDPERAESFHDETLPAEGAKIAHFCSMCGPKFCSMKITQEVRDYADKQKAQRQGMEEKAVEFVKKGAKIYS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: ROMA_KLEPN
Sequence: VPASDQLTVHVLPARHFSGRGLKRNQTLWASFLFVTPQQKIYYSGDSGYGPHFKAIGDEFGPVDLAIMENGQYDQDWKYIHMMPDETAQAADDLRARAVLPGHAGRSFWRNTAGMNRINGWRLPAKEGPGVC
What are the official names of this protein?
Outer membrane protein RomA.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv0906.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: GATC_CORK4
Sequence: MSSISRDEVAHLARLSRLSLTDDELDEFADQIDGIIEHVQKVSNVDTEGVEPMSHPSDLAGVMREDEVHPTLTAEQALDQAPASQRDRFEVPRILGE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: IHO1_HUMAN
Sequence: MNFNVWNIKEMLSIPSGSGNKKSSNWNNNQNDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRHSKQSQQNYLEGEPSIFTKYQTKPQLFGGDIKDGGLFPPPLSVGKSKGLLEQFEEKKKRAKDKCDSETLYNFVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQAQNDLVFEAVQDKGNMEQAILEMKKRFEARQGEFIEMKSNLKHLEVLVAQQSQEFQQLCEQLGQLNVPSVLAELKRLISVPPVKDSASQTSPPLAQSLNLTRQEKYTSEKPVLWQAQALPAAWNPGMGSLQPGEFDVWGEGAKNDDLQEEAALPAFGSHERNRHVKDKVVQTNCKNWAVTKTGAKNHGSSVPGHKIPSDRDLVSQGASQLTSLEINFSTSIKNACQKYQAQSMFLCDPREHLVIKQKDGTVEMRGKDKKQQPRKAHRAHRGRLIASKQKQIPIQTCKFNSKYQSPQPAISVPQSPFLGQQEPRAQPLHLQCPRSPRKPVCPILGGTVMPNKTVRAVQGRLLQLSRCSSQDNWLLSSSSQGDHQMSWFSDLNLGCSETPLCKEAGKNLLYDLGFDSSDDDGF
What is the function of this protein?
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination.  Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.  Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
What are the official names of this protein?
Interactor of HORMAD1 protein 1, Cancer/testis antigen 74, CT74, Coiled-coil domain-containing protein 36.
What are the subcellular locations of this protein?
Chromosome. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis.
Protein: ATG1_DICDI
Sequence: MKRVGDYILDKRIGWGAFAQVYKGFSIKTNEPFAIKVVDVCRLADKNSKLTENLNYEIRILKELSHTNIVRLYDVLNEETDPTFIYMIMECCEGGDFSKYIRTHKKLTEEKALYFMKQLANGLKFLRQKQIVHRDLKPQNLLLSDDSEHPILKIGDFGFAKFIDPFSLSDTFCGSPLYMAPEILHRKNYTVKADLWSVGIILYEMLVGEPAYNSGSVPDLLNQLQNKKIKLPSHISSDCQNLIYSLLQIDVEKRISWEDFFNHKWLNLNNNDSYKNNSGNYFNNNNINNNNNNNTNNNNNNISYPISINSNNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYYNNNNSPPNVYHASSLPYDFNNNNNNNNSNNYNNNTNVPNSLPFAYNNNIYSSPTEAIPQPTTLNKSKSLENTGNTIRAHPFKDDKKSTTIQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQNRQLSNLSTDFERDLVILDGEELESMERVFNRAVAIAELGDLRQNEPLECVPLYILALKLMKSKIPNDPSSSPDKFINTFTEYKRKLVHIFSTSNTSVKNQDHHSSFSPNRFIYENALEFGKKGAVEELYNNYPTSLQFYTDGTLLLEYLSSIVIDSDDQEIIKKYLNAFEVRTQICKKNYENSKNTVLNTNSIQNNT
What is the function of this protein?
Serine/threonine protein kinase involved in autophagy (PubMed:12626495, PubMed:17557329).  Involved in the control of autophagic vacuolar cell death (PubMed:15358773, PubMed:16810325).  Required for normal survival when exposed to pathogenic bacteria S. typhimurium by promoting autophagic degradation of intracellular S. typhimurium (PubMed:19667176).
What are the official names of this protein?
Serine/threonine-protein kinase atg1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: LYSK_SULTO
Sequence: MQLEKELSRRKIKELLLEILSIYTPSGEEERAKDFFEKVSKEFNLNLEISKSKSYFLGKGDILLASHIDTVPGFIQPKIEGEVIYGRGAVDAKGPLIAMLLATYILNEKGYKVQFAALADEEGKSKGARELANSGIRYNYIIIGEPSNTLDVIVEYRGVLHLDILCRGNSQHSSSSKENLIVDLSKKILEIYREPSNYENFSIVPTIIKSGDYINMTPSEGYLHLDIRYSIKNSKDEILALIHNEFKTCDIKIVEDIEPVKVDVNSNIVKAVMRGIIKQGYKPKLARKAGTSDMNILKNIAKEIVTYGPGNSTLEHTNNEKISIDEIFIALTTYINAIEELCLKKK
What is the function of this protein?
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
What are the official names of this protein?
[LysW]-lysine/[LysW]-ornithine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. LysK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRGR_PONPY
Sequence: MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAVGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEAKRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQGVLSPLMSRSGGKAGDSSGTAAAHKVLPRGLSPSRQLLLPASGSPHWSGAPVKPSPQPAAVEVEEEDGSESEDSAGPLLKGKPRALGGAAAGGGAAAVPPGVAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPSASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASTRSPRSYLVAGANPAAFPDFPLGPPPPLPPRAPPTRAGEAAVTAAPASASVSSASSSGSTLECILYKAQGAPPQQGPFAPPPXKAPGVSGCLLPRDGLPSTSASAAAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGIPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
What is the function of this protein?
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Transcriptional activator of several progesteron-dependent promoters in a variety of cell types.  Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
What are the official names of this protein?
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity).
Protein: ISPF_LISIN
Sequence: MIRIGQGYDVHKLDYDRELIIGGIKIPYEKGLLGHSDADVLLHAITDAIIGAIGALDIGHFFPDTDMAYKDADSAELLAEIWRQVEAEGFKLGNLDATIIAEKPKMAPYVELMKRRIAELLHAEPSQVNVKATTTEKLGFTGREEGIASLAVVLLEK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: MCU_HUMAN
Sequence: MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQNLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD
What is the function of this protein?
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627).  Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363).  Activity is regulated by MICU1 and MICU2.  At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221).  Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.  Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213).  While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276).  participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity).  Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870).  Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity).  Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity).  Involved in antigen processing and presentation (By similarity).
What are the official names of this protein?
Calcium uniporter protein, mitochondrial, HsMCU, Coiled-coil domain-containing protein 109A.
What is the protein family that this protein belongs to?
Belongs to the MCU (TC 1.A.77) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: WDY_ANOGA
Sequence: MAGRLSTADADREIHRFVTREQIDQLHEQFRARNNRLTLDELRELLAELGLFYTEDEYRTLCLQINTDHDRYCQWDELLSYLILGFQDDDPHAVKQSLDPPIAGDLCVKLRRQVYNIVKVDFCPMVYYDGSISWSQGHWITTSREGVIQYWTEDWKPALTARSVPSSLKRSKTWVLDTVPLPDLSMFCVTGLETELRLYNVVAACFTLKLVIERLPQPISAMAYRFGRDEPSRLLTGDYTGHIRMFVFHPERKVTTSGESTVTHVSLQDVLHGAYPPVECVDYGQLLPDIVRAVQFVESVGNVAELFIACAEENPLLSSARGRPRPAMVIHSLDLPAIRRIKFCVPRGVTCFAFEPSNELLVSGGPDCDLRLWDIHRPEKPSVVLVGHTSSITFLFLQDAGEKIYSLDQRKIIKVWDVRNRVLLQTFGQFSTVLVKGVPACAYYNKRARELVVASNKLFVTACCPEIALDRTDGESHTKPVSVLLYNGLYRLVVSCGFDSFIIVWDHRVNRKMTIITEAHTQIRNGVLEPVEITAACFDGKEQMLLTGARNGSLKIWNIGGRTCMRTIQIEEDCEVTGVFWQANRILAMGWNHRVVEFAAFAEQDEYPRGLQWRKQHSDDILCAAVSGSEPGVMATCSYAGELVFWMLETGQPYRRYDATNPRTRLPISFREGRADLMKPRKLTPRRSLFQMPPGQLAHRRLTRILMPSGLEQMRQLSIQALLFLAMRKMLPDRGTLFGSLDNGMVQVWSHHPDGGFKGQFNGIHMAGDRIITLATDKANRFLFTGTALGYVKTWYIENCWIPNEDKFHVNKPALRILFPFLLNDVVPGRAKRSARAQVKPWLLNSYQAHRACVTGLTYLDDTGLLLSCSSDRTVRLWTLGGRYIGLLGSPVNWQPLPMAVPPPADYRFRIPPDLQREVSFTTLKVLRGGKDSSRTARTKSGGGTATVGDIVGVAADRSKHTPMIETYGSPLAEPILNTAVLKLPSKEPMLQTIKLDRTYPSFPLYRHMVAFPVQPLKRTNKTVEENGSDWNELEQLLERTKALQFKDAPSDADAEGTQ
What are the official names of this protein?
WD repeat-containing protein on Y chromosome, WD40 Y.
Protein: BR2C_RANDY
Sequence: GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC
What is the function of this protein?
Antimicrobial peptide.  A mixture of Brevinin-2DYc/2DYd is active against the Gram-positive bacterium S. aureus (MIC=15 uM) and the Gram-negative bacterium E. coli (MIC=15 uM).
What are the official names of this protein?
Brevinin-2DYc.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: HIS4_SHIB3
Sequence: MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSPKMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1446_ARCFU
Sequence: MGGESDKQKKPDYFLVSVSNRRNLELCIKHAMAGFTNSINGLWTFFDIDVGDYVSFLYGARVRNLYKVVEKKAYKNAEKLPPWPPVTFKMSGKTYYFPFRLFLSQERLLDEPMVRPEFSYVAENLLLRGGYRKTHFHADSITFYNISQMGMPYEGENESLHLEAETFEPKIVFKKENETIPEKFYFREIILQSLVRKKIPNTILGEILERFGMLQNASEFEVLGEKALPEGYVDIFIKLRHPTASNRYILVEVKTGKAQRKDIRQLLEYMSEYGREAVGGVLVARDFPRKANADGVVFVNYRFDDLDVEGEYAFEKLLELLRLEVVV
What are the official names of this protein?
Uncharacterized protein AF_1446.
Protein: SUGA_ACHDO
Sequence: AAAPF
What are the official names of this protein?
Subesophageal ganglion pentapeptide.
Protein: MIBS_STRCO
Sequence: MPDSGTLGTPPPEQGPTPPTTLPDVPAPVIPSASVTSAASDFLAALHPPVTVPDPAPPPPPAPAAGNPPDTVTGDSVLQRILRGPTGPGTTSLAPAVRYGRQPGPEAPASAPPAAGRAVPGLYHHPVPEPDPVRVEEVSRRIKRWAEDEVQLYPEEWEGQFDGFSVGRYMVGCHPDAPTVDHLMLATRLMVAENAVDDCYCEDHGGSPVGLGGRLLLAHTAIDHFHSTAEYTPTWQASLAADAPRRAYDSAMGYFVRAATPSQSDRYRHDMARLHLGYLAEGAWAQTGHVPEVWEYLAMRQFNNFRPCPTITDTVGGYELPADLHARPDMQRVIALAGNATTIVNDLYSYTKELNSPGRHLNLPVVIAEREQLCERDAYLKAVEVHNELQHSFEAAAADLAEACPLPPVLRFLRGVAAWVDGNHDWHRTNTYRYSLPDFW
What is the function of this protein?
Catalyzes the cyclization of 2-methylgeranyl diphosphate (2-MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate.  Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%).
What are the official names of this protein?
2-methylisoborneol synthase, 2-MIB synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. 2-methylisoborneol synthase subfamily.
Protein: MTNN_AERS4
Sequence: MKVGIIGAMEQEVALLRSQMNEPTTLQLGGCEFYQGKLAGKEVILTRSGIGKVAASVATSLLLEKFAPDCVINTGSAGGFAQDLHIGDMVIADEMRFHDVDVTAFGYEMGQMAQQPAAFPCDGKLIAVAQDCIAEQGKHQTKVGLICTGDQFMCKPDAIAKARADFPQMLAVEMEGAAIGQVCHMFKVPYLVVRAMSDIAGKEQVESFDAFIEVAGQHSAEMIIKMLGKL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: ALIS4_ARATH
Sequence: MSTKKHNLLANFASSDSRFTQQELPACKPILTPKWVILTFLVSGVVFIPLGVICLFASQGVIEIVDRYDTDCIPLSSRDNKVRYIQGLEDKRCNRTITVTKTMKNPVYVYYQLENYYQNHRRYVKSRQDGQLRSPKDEHETKSCAPEDTLGGQPIVPCGLVAWSLFNDTYDFTRNNQKLPVNKKDISWKSDRESKFGKNVFPKNFQKGSLIGGKSLDQDIPLSEQEDLIVWMRTAALPTFRKLYGKIDTDLQAGDTIKVLLQNNYNTYSFNGKKKLVLSTTSWLGGRNDFLGIAYLTVGSICLFLAVSFSVLYLAKPRQLGDPSYLSWNRSAGGGR
What are the official names of this protein?
Putative ALA-interacting subunit 4, AtALIS4.
What is the protein family that this protein belongs to?
Belongs to the CDC50/LEM3 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.