PharMolix/UniProtQA huggingface dataset:
Protein: SYI_STAAM
Sequence: MDYKETLLMPKTDFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDKGVVDADAKFIIWTTTPWTIPSNVAITVHPELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASIKLEKEYTGKELEYVVAQHPFLDRESLVINGDHVTTDAGTGCVHTAPGHGEDDYIVGQKYELPVISPIDDKGVFTEEGGQFEGMFYDKANKAVTDLLTEKGALLKLDFITHSYPHDWRTKKPVIFRATPQWFASISKVRQDILDAIENTNFKVNWGKTRIYNMVRDRGEWVISRQRVWGVPLPVFYAENGEIIMTKETVNHVADLFAEHGSNIWFEREAKDLLPEGFTHPGSPNGTFTKETDIMDVWFDSGSSHRGVLETRPELSFPADMYLEGSDQYRGWFNSSITTSVATRGVSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQVVKQKGADIARLWVSSTDYLADVRISDEILKQTSDVYRKIRNTLRFMLGNINDFNPDTDSIPESELLEVDRYLLNRLREFTASTINNYENFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEQRDSHIRRSMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHVKEESVHLADMPKVVEVDQALLDKWRTFMNLRDDVNRALETARNEKVIGKSLEAKVTIASNDKFNASEFLTSFDALHQLFIVSQVKVVDKLDDQATAYEHGDIVIEHADGEKCERCWNYSEDLGAVDELTHLCPRCQQVVKSLV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_ANASK
Sequence: MVDPIVTKNWRDLIKPRGLVVDQDSLSNTYGKFVAEPLERGFGITLGNSLRRVLLSSLQGAAITSVKVEGVEHEFMTIPEVAEDVTDIILNLKEVLLQIHTNDVKTIRIEADGPKEIKAGDLITDAQVEVLNPGHHILTISEGGRVRAEMTARRGRGYVPAERNKIPGSPIGTIPIDALFSPIRKVNYQVTNARVGQQTDYDKLTLEVWTDGSVAPADAVAFAAKIVKEQLSIFINFDEAEEPAEEIKPVEEQKLNENLFRSVDELELSVRSANCLQNANIKTIGDLVQKTEAEMLKTKNFGRKSLKEIKEILAEMGLSLGMKLENWPPKAAPQGGAPKV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: DXS_BACLD
Sequence: MDLLSIKDPAFLKNLSNEELESLSAEIRRFLIETLSESGGHIGPNLGVVELTIALHKEFDSPKDKFLWDVGHQSYVHKLLTGRGKDFATLRQHKGLCGFPKRNESEHDVWETGHSSTSLSGAMGMAAARDLKGTNEYIIPIIGDGALTGGMALEALNHIGHEQKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYLLVSGMFFEELGFTYLGPVDGHSYDELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDKTGTWHGTGPYKIDTGDFVKPKAAAPSWSSLVSETVRKLAREDERIVAITPAMPVGSKLEGFASEFPERMFDVGIAEQHAATMAAGLATQNMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRAGLVGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGQHMVNTAVKYDDGPIAMRFPRGNGLGVKMDKELKTIPIGTWEVLRPGTDAVILTFGTTIPMALAAAEELQKEGRSVRVVNARFIKPLDENMLKEILNEGLPILTIEEAVLQGGFGSSILEFAHEHQSYSPIIDRMGIPDQFIEHGSVAKLLEEIGMTKEDVIRRIRLLTPVKTHKGIGS
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: NCAP_INCCA
Sequence: MSDRRQNRKTPDEQRKANALIINENIEAYIAICKEVGLNGDEMLILENGIAIEKAIRICCDGKYQEKREKKAREAQRADSNFNADSIGIRLVKRAGSGTNITYHAVVELTSRSRIVQILKSHWGNELNRAKIAGKRLGFSALFASNLEAIIYQRGRNAARRNGSAELFTLTQGAGIETRYKWIMEKHIGIGVLIADAKGLINGKREGKRGVDANVKLRAGTTGSPLERAMQGIEKKAFPGPLRALARRVVKANYNDAREALNVIAEASLLLKPQITNKMTMPWCMWLAARLTLKDEFTNFCAYAGRRAFEVFNIAMEKIGICSFQGTIMNDDEIESIEDKAQVLMMACFGLAYEDFSLVSAMVSHPLKLRNRMKIGNFRVGEKVSTVLSPLLRFTRWAAFAQRFALQANTSREGTQISNSAVFAVERKITTDVQRVEELLNKVQAHEDEPLQTLYKKVREQISIIGRNKSEIKEFLGSSMYDLNDQEKQNPINFRSGAHPFFFEFDPDYNPIRVKRPKKPIAKRNSNISRLEEEGMDENSEIGQAKKMKPLDQLASTSSNIPGEN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RIC8A_MOUSE
Sequence: MEPRAVADALETGEEDAVTEALRSFNREHSQSFTFDDAQQEDRKRLAKLLVSVLEQGLSPKHRVTWLQTIRILSRDRSCLDSFASRQSLHALACYADITVSEEPIPQSPDMDVLLESLKCLCNLVLSSPTAQMLAAEARLVVRLAERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLLTDALELTLGVAPKENPPVMLPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRHCVMVEAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVISALLAFLEKRLHQTHRLKECVAPVLNVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTEEYREAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD
What is the function of this protein?
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.  Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.  Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex.  Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).
What are the official names of this protein?
Synembryn-A, Protein Ric-8A.
What is the protein family that this protein belongs to?
Belongs to the synembryn family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). Colocalizes with RIC8A in CA2 hippocampal neurons.
Protein: SYP_TERTT
Sequence: MRASQYLIATQKETPADAEVISHKLMLRAGLIRKMASGLYNWLPLGLRVLRKVENIVRQEMDKSGAQEVLMPVVQPAEIWQESGRWQQYGPELLRINDRHDRAFCLGPTHEEVITDLIRNEVKSYKQLPLNFYQIQTKFRDEVRPRFGVMRAREFLMKDAYSFHISQESLQETYDVMHRTYCNIFDRIGLQYRPVLADTGSIGGSASHEFHVLADSGEDDIAFSSDSDFAANVELAEALAPAKQTPGSSGAEEKHTPSQKSIEEVAAFLSVTPAQTLKTLIVLGETEDEGPAPLVALVLRGDHSLNDIKVSKLEGVADPLTFAPEERIKNELGAEVGSLGPIGLKITVIADRAAAACADFVCGANKTDYHLINANWDKEASYSRVEDLRNVVVGDPSPCGKGTIEIKRGIEVGHIFQLGTKYSAAMKATVLDENGKDVTMTMGCYGIGVSRIVASAIEQNHDDNGIIWPDAIAPFQLAIVPINMHKSDAVKEACETLYDQCQTAGIDVLLMDEPKARLGAMLADVELVGIPHRVVIGDRGLEQGNIEYKGRRDAESQEVAAASLFEFLREKIAP
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBCN_ECOLI
Sequence: MNLSQDGIKLHRGNFTAIGRQIQPYLEEGKCFRMVLKPWREKRSLSQNALSHMWYSEISEYLISRGKTFATPAWVKDALKHTYLGYETKDLVDVVTGDITTIQSLRHTSDLDTGEMYVFLCKVEAWAMNIGCHLTIPQSCEFQLLRDKQEA
What are the official names of this protein?
Uncharacterized protein YbcN.
What is the protein family that this protein belongs to?
To equivalent protein in phage 82.
Protein: ACON2_ASPFU
Sequence: MVRQLVWQRATASRRLAPKCLSPQQLFARRGLATEASAARMPPYPKIVRNLEQVRKVLGSSRALTLAEKILYAHLDNAEESLLTGTNNGKDIRGKANLKLKPDRVAMQDASAQMALLQFMSCGLPSTAVPASIHCDHMIVGERGADTDLPASIEGNREVFDFLESAAKRYGIEFWPPGAGIIHQSVLENYAAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALVDAPWELKAPRILGVRLEGRLSGWASPKDIILHLAGKLTVRGGTGYVIEYHGPGVETLSCTGMATCCNMGAEVGATTSVFPFSPSMVPYLQATHRGHVAQAAAEIAASGPKNLLRADDGAEYDQLITIDLSTLEPHVNGPFTPDLSVRLSDFANTVRENKWPETLGAGLIGSCTNSSYEDMTRAEDLVKQASAAGLKPKADFFITPGSEQIRATLDRDQTLASFSEAGGTVLANACGPCIGQWKRTDGVAKGEDNAIFTSYNRNFPGRNDGNRRTMNFLASPEIVTALAYSGSTTFNPMTDTLKTPSGEEFKFRPPQGSDLPSAGFADGNPALQPSAGVPDASVEVIVSPTSERLALLEPFAPFPEGELSGLKVLYKVKGQCTTDTISAAGPWLKYKGHLPNISANTLIGAVNAATGETNVAYDDAGNKHSIPDLAARWKADGIEWLVVAEDNYGEGSAREHAALQPRYLGGRIIVAKSFARIHETNLKKQGVVPLTFADKADYDRIDACDQVDTVGLYETLQSGGQGSIQLQVTKKSGEKLTIPVNHTLSKDQCGFILAGSALNLLAKRAHQ
What is the function of this protein?
Has no detectable activity towards cis-acontiate or cis-homoaconitate.
What are the official names of this protein?
Putative aconitate hydratase, mitochondrial, Aconitase 2.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: C1QT9_BOVIN
Sequence: MRIWWLLLASGVCTGMVSSQDTCKQGHPGIPGNPGHNGLPGRDGRDGAKGDKGDAGEPGHPGGPGKDGMTGKKGEPGADGHVEAKGIKGDQGSRGPPGKHGPKGLVGPPGEKGLTGETGPQGQKGEKGDVGPVGPEGPEGSTGPSGPTGLLGPTGPIGKPGPKGDAGPLGPQGEPGVRGPRGWKGERGEKGKIGEMPALPKSAFTVGLTVLSKFPPSDTPIKFDRILYNEFGHYDVATGKFICHVAGVYYFTYHITVFSRNIQVSLVKNGAKVLHTKDGYTGSEDQASGGIVLPLKLGDEVWLQVTGGERFNGLFADKDDDTTFTGFLLFSSS
What are the official names of this protein?
Complement C1q and tumor necrosis factor-related protein 9.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMKL_METCA
Sequence: MPMTRDFFATAPKGLEPLLVRELDGLGAESIKETRAGVEFRGTLETAYRVCLWSRLANRILMSLDRFAAATPEALYDGVQRTDWGRHFGPGATLAVDFSSRRSAITHTLFGAQKVKDAIADQFLEHCGRRPSVRLERPDIRINVHLDADQAVIGLDLSGDSLHRRGYRTEAGPAPLKENLAAAVLIRAGWPDIAARGGSLIDPMCGSATLLIEGALLAADIAPGSFREYFGFLAWKGHDLELWRKLLTEARERAEAGLARLPPILGYDLDRRAIHLALDNIDRAGLRGRIHVERKVAADVRPKGRPGLVVVNPPYGERLGDVESLIPVYREFGETLQRHFRGWNAALLTGNFELAFQIGIRAGRYHTLYNGALECRLFLFDIAPERFFTPRSGVPETEGQKKLRQIVEKARRGAIPAEQSEMFANRLRKNLRNLGTWARRNGVSCYRLYDADLPEFAVAVDIYQGEKLWVHVQEYEAPASVDPAKAQSRLAGAVAMIPEVLEVPREQIFLKVRRRQKGDAQYVKQGQTAHFHVVEEGGWRFWVNFEDYLDTGLFLDHRITRGLIQQVARDRHFLNLFAYTGTATVYAAGGGAASTTTVDMSHTYLDWAGRNLALNGFGERDHLRIQADCLDWLEQAVDRRRRYGLIFLDPPTFSNSKRMTGSFDIQRDQGPLLKKVVSLLEPGGMLIFSTNRRRFRLDETALAGCAVEDVSRVTLPKDFERNPRIHACWRILAPDRQR
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPG_SALTY
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRGELARFIENPGDPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS7_STRAW
Sequence: MSRVGRVERTTKETSVLVEIDLDGSGKVDVSTGVGFYDHMLDQLGRHGLFDLTVKTEGDLHIDSHHTIEDTALALGAAFKQALGDKVGIYRFGNCTVPLDESLAQVTVDLSGRPYLVHTEPENMAPMIGEYDTTMTRHILESFVAQAQIALHVHVPYGRNAHHIVECQFKALARALRYASERDPRAAGILPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFQ_CLOAB
Sequence: MNNKSTNNLQDIFLNSARKNKIPVAIHLTNGFQMRGSVKGFDSFTVILESDGKQMMIYKHAVSTITPLRPILFNQPQQDEE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: SP5G_BACVZ
Sequence: MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLFVAMPSKRTPDGEFRDIAHPINSSTRGKIQDAVLNEYHRLGDSEALEYEEAGAS
What is the function of this protein?
Essential for sporulation.  Interferes with or is a negative regulator of the pathway leading to asymmetric septation.
What are the official names of this protein?
Putative septation protein SpoVG, Stage V sporulation protein G.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: SELO_DESPS
Sequence: MMNFSNSYRQLGSDFYEESLPTPVLAPRLLLWNAPLAEQLMIPEELGQAALAQIFSGNQLLPGSEPIAMAYAGHQFGSFVPQLGDGRAHLLGEVFDKSGQRWDIQLKGSGPTQFSRGGDGRCAVGPALREFIMSEAMYALGVPTSRCLAVVTSGEDVYRRSILPGAIVTRIASSHLRVGTFEFFAARGEHEALKRLCDYTIDRHFPELQGATDQYIRFLDRVIGRQIQLITEWMRVGFIHGVMNTDNTSLAGETIDYGPCAMLGAYDPHTVYSSIDIKKRYAFGNQSAISQWNMTRLAECLLPLINADRNRAIDQLNPLLIAYTDRFNRVYIKMMGKKLGLTSLQAKDEKLIISLLDQLKIGKMDYTLTFDLLTKSLSSEPIASQMRGQLGNYFDLWQRRLKEQGTDLQEVQTLMRQQNPLLIPRNHHIEAAIAECEQTGRVNLAEKLLHVLRAPYEELTETHLYQDPPSDGDKNYQTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: ASAH1_MACFA
Sequence: MLGRSRLALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGPAPWYTINLDLPPYKRWHELMVDKAPMLKVIVNSLKNMVNTFVPSGKVMQIVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISYNIFYEFFTLCTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEELKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSVNGGYLGILEWILGKKDAMWIGFLTRTVLENSTSYEEAKNILTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKNPFFLDDRRTPAKMCLNRTTQENISFENMYDVLSTKPVLNKLTVFTTLIDVTKDQFETYMRDCPDPCIGW
What is the function of this protein?
Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity).  Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity).  Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity).  For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity).  Has also an N-acylethanolamine hydrolase activity (By similarity).  By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity).  Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity).  By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity).
What are the official names of this protein?
Acid ceramidase, AC, ACDase, Acid CDase, Acylsphingosine deacylase, N-acylethanolamine hydrolase ASAH1, N-acylsphingosine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acid ceramidase family.
What are the subcellular locations of this protein?
Lysosome. Secreted. Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent.
Protein: MURC_SALTY
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIADDAILRALESFQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKLKPQIQEEEQHG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRP2_MOUSE
Sequence: MDMFPLTWVFLALYFSGHEVRSQQDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSVLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPRMEIILQFLTFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSKLRSSTGILSLTFHTDMAVAKDGFSARYYLIHQEPPENFQCNVPLGMESGRIANEQISASSTFSDGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQKGYYVKSYKLEVSTNGEDWMVYRHGKNHKIFQANNDATEVVLNKLHMPLLTRFIRIRPQTWHLGIALRLELFGCRVTDAPCSNMLGMLSGLIADTQISASSTREYLWSPSAARLVSSRSGWFPRNPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQTKLFEGNMHYDTPDIRRFDPVPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPMDEDATECGENCSFEDDKDLQLPSGFNCNFDFPEETCGWVYDHAKWLRSTWISSANPNDRTFPDDKNFLKLQSDGRREGQYGRLISPPVHLPRSPVCMEFQYQAMGGHGVALQVVREASQESKLLWVIREDQGSEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEISIDDIRISTDVPLENCMEPISAFAGEDFKVDIPETHGGEGYEDEIDDEYEGDWSNSSSSTSGAGDPSSGKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKINHQKCCSEA
What is the function of this protein?
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
What are the official names of this protein?
Neuropilin-2, Vascular endothelial cell growth factor 165 receptor 2.
What is the protein family that this protein belongs to?
Belongs to the neuropilin family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: HSLU_YERPP
Sequence: MSEMTPREIVSELDSHIIGQDKAKRAVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRHQSIEKMRYRAEELAEERILDVLIPPAKNNWGVPDESQEPSATRQTFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTNQLQSMFQNIAGQKQKPRKIKIKEALKLLIEEEAAKLVNPEELKQQAIDAVEQHGIVFIDEIDKICKRGQTSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQVSSPSDLIPELQGRLPIRVELQALTTDDFERILTEPSASLTEQYKALMATEGVTIEFTREGIRKIAEAAWQVNERTENIGARRLHTVLERLMEDISYDASESSGQSITIDAEYVGKHLDELVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_PARUW
Sequence: MKYDHQQIEAKWQKFWQDNQTYRSDDNFQKPKYYVLDMFPYPSGAGLHVGHVVGYTATDIIARYMRTKGYNVMHPMGWDSFGLPAEQYAIRTGTHPAESTQENINNYRRQLRALGFSYDWNRELATSDPNYYKWTQWIFTKLYEKGLAYEAEMLVNYCPALGTVLANEEIENGKTKDGGHPVERRPLKQWILKITAYADRLLQDLDLLDWPESLKKLQINWIGKSEGAYVQFIEKTTQEAFSVFTTRPDTLFGVSYLVLAPEHPLVSHITASSQQQAVRAYQAQIASKSDLDRTELNRDKTGVFTGAYAVNPVNHKEIPIWISDYVLMNVGTGAIMAVPAHDERDFEFAKTFKLPIIPVYDPVCEEITIRNQVLAGQQCWPGHGICVNSACGDLSLNGLNLDQAKKIVINWLEINHKGKSATTYKLRDWLFSRQRYWGEPFPLLKFEDGSVRLLDEDELPLCPPAITNYKPTGDGKGPLTQIKEWVEIIDTKTGKKAFRDTNIMPQWAGSCWYYLRFCDPHNTEKAFSPEKEKYWLPVDLYIGGVEHAVLHLLYARFWHKVLYDCGYVHTLEPFQTLRNQGLVVARSYQNKMRVYVEPRYVEQRDGKYFDSRTGEELTSQIDKMSKSKLNGESPDEIIQEYGADALRLYEMFMGPLEKEKVWNTDAVSGTRRFLNRFYEMAFSDKVTNETSEEGLKLGHRLVHSVMKDMELLQFNTAIAKMMEFINEFTKLVTYPKQVIQMATQVLAPFAPHLAEEVWEHLKCEGSLSFTPYPQVEEKYLQENVITYVVQINGKVRGRFDLPKDQTQENVLEAAKNNPHIQQYINKKEIGKVVFVPNKLLSIVLR
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIMD_PORG3
Sequence: MRTNRILNIICPPILFLLVGFLFGCVREDIESDMNETSSLFLQVQPYNQRSEEGGVAAYDENTIERLTLVFYKNGTKVWQAEPVETSPSSNSYYVPVPESMYGQFNGNNSFKIYLVANVNFSGSFEPNASETSFLKTLVPNSILLQNDGKPEDKFAMIGSVEKQINMATSEGKQLGSIELKRVAAKLRLKKPVLNISDYELVGDPKAKFRNCMPKGFLSVEEKPEGVGYEAIDYRPMTEANSSVHFYSYYNEWALNNEGRPEFVMMLKLKKTGTDDNTAKPYYYRIPVDGSDKKIRSNHLYDMAVTIEVLGSLNEEDPVTINGSLSVIEWTSHSDDQTLPDVQYLEVIPQETVMNMTTEIELDYFSSHSLLPPADVKATCTYVNSNGQQITDTYTGANVPTVTIDANTKKIKVRSILPINNIPKDISFTIKNSIGFEKKIKIRQNPSQFIINTFGTKSSWQPEGNLAPNLNNKAIYQIVVLSPPADGNMIIGFPPTKEVGFYKKSGSSYTLKHTDRITEQDEQTANMVSPSFELASQLGATLVQDHWEYYTLNPLRLIYHSNQQNRYALMTCAFYWEERKKADGTIERLDDWRLPTRAEIQLVDKLQREQAGVVRDIMTGRYYWSGLPDKAIKILLPTASGNATEQRAHVRCVRDVKNDRFVKSAKRLKK
What is the function of this protein?
Probably a component of the fimbrium tip (PubMed:17526848, PubMed:19506009).  These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:17526848).  They play an important role in invasion of periodontal tissues and are major virulence factors.  FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response (PubMed:17675496, PubMed:19506009).
What are the official names of this protein?
Major fimbrium tip subunit FimD.
What is the protein family that this protein belongs to?
Belongs to the FimD family.
What are the subcellular locations of this protein?
Fimbrium. Cell outer membrane. Note=Probably synthesized as a palmitoylated precursor. Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide (Probable). Probably part of the fimbrium tip, as a part of the complex formed by FimC, FimD and FimE.