PharMolix/UniProtQA huggingface dataset:
Protein: TBB3_HUMAN
Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:34996871).  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871).  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871).  TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521).  Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977).  Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).
What are the official names of this protein?
Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium.
Protein: TATD_PECAS
Sequence: MFDIGVNLTSSQFEKDREQVVIRAKLAGVSGILITGTNAQESHQAMLLAQAYPDYCWSTAGVHPHDASQWNDAIAEQLHQMANAACVVSIGECGLDFNRNFSTPEEQEQAFSAQLAIAAELSMPVFLHCRDAHPRFISLLTPWLSQLPAAVVHCFTGNRHELDECLAAGLMIGITGWVCDERRGLELRALLPHIPADRLLVETDAPYLLPRDLRPKPASRRNEPCYLPHIIRQIAEWRGEDATWLGQTTDENARRVFRLA
What is the function of this protein?
3'-5' exonuclease that prefers single-stranded DNA and RNA.  May play a role in the H(2)O(2)-induced DNA damage repair.
What are the official names of this protein?
3'-5' ssDNA/RNA exonuclease TatD, DNase TatD.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_BORBR
Sequence: MTAPGFVEFPDSPFHLYQPYPPAGDQPGAIDALTEGVSDGLMFQTLLGVTGSGKTYTMANMIARLGRPALVLAPNKTLAAQLYAEMREFFPRNAVEYFVSYYDYYQPEAYVPTRDLFIEKDSSINEHIEQMRLSATKSLLERRDTVIVGTVSCIYGIGNPGDYHAMVLILRTGDRISRREVLARLVAMQYTRNDADFTRGVFRVRGETIDIFPAESPELALRLTLFDDEIESLELFDPLTGRVRQKLPRFTVYPGSHYVTPRETVLRAIETIKEELRERLAQLIADGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHLSGAAPGEPPPTLIDYLPADALMFIDESHVTIGQLGGMYRGDRSRKETLVQYGFRLPSALDNRPLRLEEFEARMRQCVFVSATPAAYEQEHADNVVEQVVRPTGLVDPIVEVRPAHTQVDDLLGEIHKRAALQERVLVTTLTKRMAEDLTDFLSEHGVRVRYLHSDIDTVERVEIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGRAILYADRITDSMRRAIDETERRRAKQIQHNTDHGITARGVSKAVRELIDGVVAPAGHDALESAVPAEVLTDEKAMAREIRRLEKLMMDHARNLEFEQAAAARDALNALKSRLLLDGVG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CREN7_SACSH
Sequence: MSSGKKAVKVKTPAGKEAELVPEKVWALAPKGRKGVKIGLFKDPETGKYFRHKLPDDYPI
What is the function of this protein?
A probable chromatin protein, binds double-strand DNA without sequence specificity.  Constrains negative DNA supercoils (By similarity).
What are the official names of this protein?
Chromatin protein Cren7.
What is the protein family that this protein belongs to?
Belongs to the Cren7 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NBN_DANRE
Sequence: MWKLQPTESGGESVILLAGQEYVVGRKNCEILLTNDQSISRVHAVLTVTEQAVTLKDSSKYGTFVNGEKLESGSTKTLQTGYKITFGVFQSKFSLEKECIVVCSSCVDNEGKVTLSQDIRSVGGRLVSSWTSDCTHLVMPTVKVTIKTICALLCCRPIVKPAFFSALSKAVQQKLPLPKAERFRPQIDEPSLARDDVDLSARPERKSLFKGKTFLFLSSKQMKRLSVAVSCGGGVSQLLDEGALPVSLLESSSTCVLDMISGNSQPVISPASKKWLDSVGQILHRKGLRFITESEVGLAAIHVSNQTYCNPCSSLQSESVKTNPVFASATLSQSTAVDETALAAPSQNITAYVVNTEISQDQSRMVTSGISAVGETPEKTNPTQKASTTNKPLSLGQEPSSTRIVQETVMSSESFSVVESEQKMKKGSVVSARGRVEGPVKQKAPSSGNTTLKHSPQKQTALTSFFQPSSKKRPRESSASSVQPEPKFFKKDIKDNEDDIQQSFSVNRSHKTSSEETSLGQACGTGQNSSSKKRKEPEQDTLLGAEEPTAADDLEMSLEELEFLMSDEMDEPPQTAANKKQRLESGLTSKINSEQLSNQQEVTESKGRKGEKNQQSSSSNIQSMQLDRAGPAVTNQDTQTQSKRSPPDLEAHSSANKGPSKNKTPELEEVKKEEVSFVVNSRPQNGISQTSEAVLKQEMQASTSNSGPKNDPDLPRKLLQVQFMSLTVNNSSRSRPGPLQTHNPNDKNVKRFRKKNVPGFDGLPKIIGGSDLVAHNRSKHSELEEWLRQAAEEEKLNEREETLGDDLFRYNPRPAKKR
What is the function of this protein?
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity.  The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.  The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (By similarity).
What are the official names of this protein?
Nibrin, Nijmegen breakage syndrome protein 1 homolog.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: PUR9_DINSH
Sequence: MTDLVPLRRALLSVSDKTGLVPLGQALAARGVELLSTGGTAKALREAGLDVVDVSDVTGFPEMMDGRVKTLHPKVHGGLLALRDNAAHVSAMERHGIGAIDLLVVNLYPFEATVAAGADYAACIENIDIGGPAMIRAAAKNHSFVTVLTDVEDYEALLGELEAREGATGYPFRQKMALNAYARTAAYDAAVSGWMTDALAEVAPRRRAVAGTLAQTLRYGENPHQGAAFYVDGSDRPGVATAVQHQGKELSYNNINDTDAAFELVAEFAPEDGPACAIIKHANPCGVARGATLAEAYTKAFQCDQTSAFGGIIALNRPLDGPTAEAISGIFTEVVIAPGADETARAVFAAKKNLRLLTTEGLPDPKAPALTVRQVSGGYLVQDKDNGNIGWDDLKVVTKRAPSEAEIADLLFAWKVAKHVKSNAIVYVKDGATVGVGAGQMSRVDSARIAARKSADMAEALGLETPLIQGSVVASDAFFPFPDGLLTAAEAGATAVIQPGGSMRDVEVIAAADAAGLAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: FA47A_HUMAN
Sequence: MGDQRLQDWLRSPGMDSKPWYCNKRPSKCFAKCKHRRLRFPPMDTQNWVFVKEGMDDFRYGCPSPEDTLVCRRDEFLLPKISLRGPQADPKSGQKKLLKKAALFSKLSPAQLARKAFVEQVEAQLMAKHPLAMYPNLGEDMPPDLLLQVLKHLDPERELEDAWACCETQEKTTEVPTEPGKHPCGEFCLKPPETPVSHLLPEPPETGVSHLSPEPPKTPVSSLRPEPPETGVSHLRPEPPETGVSHIRPGPPITRRRSSLLRQLLKLDSERKLEDARAPCEGREKTTDEPTEPGKYPCGKFCPRPFETPLSHLRQEPPKTPVSSLRPEPPETGESHLRLEHSKTRRGSSLRSEPSETGVSRLRLAPPKTRRGSSLHAEPSKTGVSHLSPEPPKTEVSHLHPVPPKTGVCHLRLEPPDTSQVSNLLLYILKVLDSGRTLKDVWDRCEARVKKTKEPTEPHKSPCGEPCLQPPETQVSHPHPEHPKTRRRSSLHSQPPKTRRTSSLRSEPPKTRRTSSLRSEPPKTRRTSSLGPEPPKTRRVSSLRPELPKSRRVSSLHPEPPKAPESHQFSEPPKIRASYIKELLQEDTPSTKECVSDSLQYRYTSEKLREFFKWAGDLGADEESIRNLFDFTPKYRATHEDQKFKKVKECSSELKYSMELDEKDEDKFFSQEKYWGRKFHTPSNSYTAQRVKMKYGAWYLKPKLWKKLRSDEPLIDPKLLLKKPDEPDVLDDLYGPIAFKDFILSKGYEMPGIIQRLFARRGWTYDSVKTPIQRAMIFYKYKEIVEASEED
What are the official names of this protein?
Protein FAM47A.
What is the protein family that this protein belongs to?
Belongs to the FAM47 family.
Protein: ERA_VIBVY
Sequence: MADNEFDIDAFFSTEKKSTSSENQHCGFIAIVGRPNVGKSTLLNKILGQKISITSRKPQTTRHRIMGVDTDGDYQAIYVDTPGLHIEEKRAINRLMNRAANSSLSDVNLVFFLVDGTHWTNDDEMVLNKLQKANFPVVLCVNKVDNVQDRNEVMQHMMEMSKKMNFVDVVPISAKQGKNIDVLRKHVRDHLPKAVHHFPEEYVTDRSQRFMASEIVREKLMRFTGDELPYSVTVEIERFDYNPETDGFHINALILVERSGQKKMVIGKGGEKIKTIGREARLDMEELFGRKVYLETWVKVKSGWADDERALRSLGYIDDL
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: HSLO_CLOB8
Sequence: MKDKIVRATAKDGMVRIIAGITTNLVNEGCKIHECTPVASAALGRMLTAGTLIGTTLKSEKEVVTLKINGNGEINGITVTAHSDASVKGFIGNPYVDRPLNEKGKLDVGGAIGTDGILYVIKDLGLRDPYIGQVPIQTGEIAEDFAYYFTASEQTPSAVSLGVLVDRDLSIKAAGGFIVQMMPGADELLADVITYRLEEIPPITTLISEGKTIEEILEYIFDGMDLKVLDSLTPEYKCDCSRERVEKALISIGKETLQEIYDDKKNEEIVCNFCNTKYEFTNDEIGELLNNSR
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_SYNJA
Sequence: MLWETSSLRPPTGARDFLPREVQRRERLEAQLTQVFRRYGYQRIITPTLEPLETLLAGGSIRAEAVLQLRDGEGTMLGLRPEFTASIVRAAATRLASGPLPLRLYYHGNVFRNSRREEGSYSSQEFFQSGVELIGAGGWLADAEILLLLADCVRAVGLSNWTLLLGDVSLTESLLNSVTPKAQAAVRRAIAQLDYVYLEAAPLPEAARQIGLQILGLRGQPEQVLPQLAQLPVSPERLRDLRQLCQILEAQQVRVVLDLSLLQTLAYYTGIVFQAVVGGEIIALGGRYDRLYALYSPQQLEQPGIGFTLLPDTLLRLLPPTPQDEATGCKRLVVPLVPAGIPAALALAARWRESEAVELELLDRSPEEIEAYARRCRIPEIAWVQADGSYHISPVKYPEPPDPTGHCGPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_LACSA
Sequence: IQVAAQNCWVKKGGAFTGEVSAEMLANLGVPWVILGHSERRALLNETNEFVGDKVAYALSQGLKVIACVGETLEQREAGTTMEVVAAQTKAIADKISSWDNVVLAYEPVWAIGTGKVASPAQAQEVHAGLRKWFCDNVSAEVSASTRIIYGGSVSGSNCKELGGQTDVDGFLVGGASLKPEFIDIIKAAEVKKSA
What are the official names of this protein?
Triosephosphate isomerase, cytosolic, TIM, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_ACTP7
Sequence: MNQYAVWGNPIAQSKSPRIHQLFGEQTGKSISYVAKLGNELNFENELMQFFAEGAKGANITAPFKERAFSLADEYSESCLLAEACNTLKRLDDGRLYADNTDGFGLCSDLERLGWLKPHQRVLILGAGGATKGVLFPLLKAKQQITIYNRTLEKAVRLAEKFAKYGKIRTASLEQIAEQQFDLIINATSLGLQGKYVPVAAHLLKSAAVYDMQYAPDMQTPFLNYARECGAVRYQDGLGMLVGQAGFAFKLWENEFPNVEKVLKQLKNEMENAK
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: YIHI_SALDC
Sequence: MKKPTSAPRSKAFGKQRRKTREELNQEARDRKRLKKHRGHAPGSRAAGGNSASGGGNQNQQKDPRIGSKTPVPLGVTEKVTQQHKPKSEKPMLSPQAELDLLETDERLDALLERLEAGETLSAEDQAWVDAKLDRIDELMQKLGLSYDDDEEDDEEDEKQEDMMRLLRGGN
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: US109_SCHPO
Sequence: MSTSLWLNNLEEWMNEDYIRAIFENVRKVNYYEDGESGAILKTCCIEFESQDAARNALERQSTQRLISGNPISLDVVPEWQKPSYYMLFISNIDPEVSENDIKYLFQRYNFISARVLRCVDGTSTSIAFIWLANESDIQNAQVEMQGAFCLKRSILVHSVKSDKNTYLSSPGFYGTPQPLNQFTDPNNTAVYVHQLPENITTQELRSYFLHFGEILYTQVNNNSGRIVFAQRYFAEQAINEMNNFPLHGVRIQLSWARPPSMALLPSKQSTYWPALAAPVYPSMKDVPNNPFTPFSPINPYYAKSWNHTASAPLLPPGLKNGSDYPYLSVPPDILNDSYLAMCEAVNSRLDAESTMLLPVHYSQA
What are the official names of this protein?
U1 snRNP-associated protein usp109.
What are the subcellular locations of this protein?
Nucleus.
Protein: NADA_PROMM
Sequence: MVRMTAVCTAKTVSPVPSTRKELKGAIAELRKKLNAVILAHYYQDPEIQDIADFIGDSLELSRRAASTNADVIVFCGVHFMAETAKILSPEKIVLLPDLEAGCSLADDCPADEFAAFRDKHPDHIVVSYINCTAAVKAQSDLICTSSNAVELVNQLPKDQPILFAPDQNLGRWVQKQSGRKLTIWPGRCMVHETFSEEALLKLKIMHPEAKVIAHPECLENLLELADYIGSTSKLLEFTEISSCTKFIVLTEPGILHQMKLKNPKKEFMDVPGIDGCSCNECPYMRLNTLEKLWSCLSTMKPSIEIEEGVRQKAFIPIQRMLNMKETQEASEH
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRT1_PHAJA
Sequence: SLGGFLKGVGKALAGVGKVVADQFGNLLQAGQ
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Dermatoxin-J1, DRT-J1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermatoxin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMJ_NEIG2
Sequence: MTDILIDDTATEAVRTLIRAFPLVPVSQPPEQGSYLLAEHDTVSLRLVGEKSNVIVDFTSGAAQYRRTKGGGELIAKAVNHTAHPTVWDATAGLGRDSFVLASLGLTVTAFEQHPAVACLLSDGIRRALLNPETQDTAARINLHFGNAAEQMPALVKTQGKPDIVYLDPMYPERRKSAAVKKEMAYFHRLVGEAQDEVILLHTARQTAKKRVVVKRPRLGEHLAGQAPAYQYTGKSTRFDVYLPYGADKG
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGFV2_NOTSC
Sequence: MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSAANIIVDPKLFQKRRFQSPRVLFSTQPPPLSRDEQSVEFLDNEDTLNRNIRAKRENHPVHNQGEHSVCDSVSDWVIKTTATDIRGNMVTVMVDINRNNEVYKQYFFETKCRNPNPNPVQSERRGIDSRLWNSYCTTTQTFVRALTMEGNQASWRFIRIDTACVCVIIRKTDNF
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor 2, v-NGF-2, vNGF-2.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: XGPT_ECOSM
Sequence: MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMGVVFVPPISGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GRLN_DICDI
Sequence: MKLYTHKINRIVDGYLDNLNKFGLNYMFEQDLIKITLDLGIPNNNIKFYNLNNSNSNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNSNNINNKNDILYNIIIEEKIDLIIFYKSIFSENANNISKTFNNLTTIIINDNIISNTNNNNNNNNKFYEINYPFKISTLLSGYISGLISETNIIGYLKTNKIQDQTLLDTFYFGARLSNPMVKLMFYTIDYDFKNASNNNFPFQEIIELSVSSLLKNGVDLISSSFENNEYLTFCNILLKQNIKIIGSNGFLISPPLNKDHVLFNSVYNLTLYILPIISNLINNTNTNNNNNTNNNESTNSQFNINLIFNPSISNLIINNINSNLSMIENQILNDTNIILTNQLNNESIIDLGIISGYILFKPISKTIEYGITIVSSILIGALIIIQICIIKYKNKPSFKSASPTFLIFIVIGGIFVYIGVIIWVSGVNVFTCNAKFWLISLGLTTMIGGIVVKNFRIWLIFDNPKLYHIKITNLQLLPWVLGMFLLNVFLLSLITGLGKLTPFKVFPNDEKFSSYEIQCEMMDGGLIALYFLLGYFAIIVMIGIFVSWKIRIVDIEEFNESKSVAYSLYSIVFCLLIIAPLTISKTGHNTEILCSGFIFIVAAIITIMFIPKFWALKIYGAEGSNEIFRQSSSSTSKRKNKSSTTNDPTNLDSISKKSSKNAPKRVNLFLYDFTDDDEESKQSSSSSKGDTIECMDVFTFIESVQPNSEAANEMTYNDDPTYTEPSEQPTYTESSEQPNPTPRTLTATPRTNDLTTPRTNDLTTPRTNDLITPRTNDLSTPRTNDLNTPRTDGILTPRSINSLATPRVEEPMSPRQYHNMMITLSPILEEENIVVVEKDEVIENSDSESESSDSNSDSIIQ
What are the official names of this protein?
Metabotropic glutamate receptor-like protein N.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRAD1_MACFA
Sequence: MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPICKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMRLPQRPLRAFESDVFHDRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEDGANLDFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPSSLSDIKGAADETMLPCEFCEELYPEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEHDVIFQNFLQQAASKQLDSLMGLSSSRLVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQENSPELPRRRVRHQGDLSSGYLDDIKQETANGPTSCLPPSRPFNNMTATYNQLSRSTSGPRPGCQPSPPRVLKLNNSDSQDIQGRNQNSQNGAIAPGHISVIRPPQSLYPENIVPSFPHGPAGRYGASGRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE
What is the function of this protein?
Negative feedback regulator that controls excessive innate immune responses.  Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways.  May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation.  May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).
What are the official names of this protein?
TRAF-type zinc finger domain-containing protein 1.
Protein: RL27_PHOPR
Sequence: MAHKKAGGSTNNGRDSESKRLGVKRFGGESVLAGNIIVRQRGTKFHAGTNVGLGKDHTLFALTDGKVKFEVKGPKNRKFVTIEAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CA189_CONAJ
Sequence: MFTVFLLVVLATTVVSFTSDRAFRGRNAAAKASGLVGLTDKRQECCSYPACNLDHPELCG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
What are the official names of this protein?
Alpha-conotoxin-like 289.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DRD1_MOUSE
Sequence: MAPNTSTMDETGLPVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPVECSQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKREEAGGIPKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
What is the function of this protein?
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
What are the official names of this protein?
D(1A) dopamine receptor, Dopamine D1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
Protein: IDI_SHIDS
Sequence: MQTEHVILLNAQGVPTGTLEKYAAHTADTRLHLAFSSWLFNAKGQLLVTRRALSKKAWPGVWTNSVCGHPQLGESNEDAVIRRCRYELGVEITPPESIYPDFRYRATDPNGIVENEVCPVFAARTTSALQINDDEVMDYQWCDLADVLRGIDATPWAFSPWMVMQATNREARIRLSAFTQLK
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_OSMMO
Sequence: MSSLCDTSNGESHADPCQDKEHPRMLIPELCRLFYQLGWVTGTGGGISLRHGDQIYIAPSGVQKERIQPEDMFVCDVAERDISSPPAWKKLRKSQCTPLFMNAYTMRAAQAVIHTHSKAAVMATLLYPGKEFRITHQEMIKGIRKGNSGTNYRYNDTLVVPIIENTPEEQDLKERMALAMEEYPEACAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVQMKQCGLDPSAVPSEEIDIV
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).  Functions in the methionine salvage pathway.  May play a role in apoptosis.
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase, APAF1-interacting protein homolog.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INSD7_ECOLI
Sequence: MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsD for insertion element IS2 on F plasmid.