PharMolix/UniProtQA huggingface dataset:
Protein: TUSA_ALLVD
Sequence: MADFDQELDASGLNCPLPILRAKKTLNAMSSGQVLHVIATDPGSVKDFDAFAKQTGNELMESKEEGGKFHFLIKKS
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking for oxidative dissimilatory sulfur metabolism.  Component of a sulfur relay system that starts with the sulfur-mobilizing rhodanese-like protein Rhd_2599 (Alvin_2599), which transfers the sulfur from a low-molecular-weight thiol, maybe glutathione, to the TusA protein (Alvin_2600); TusA serves as the sulfur donor for DsrEFH, which persulfurates DsrC; persulfurated DsrC very probably serves as a direct substrate for reverse-acting sulfite reductase, DsrAB.  TusA seems to be not exclusively dedicated to sulfur oxidation and may have other important roles in the cell.  Might also act as a sulfur mediator required for 2-thiouridine formation of tRNA.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_PERMH
Sequence: MSVERTLMLVKPDAVRRNLEGKIIAHVQEKGFKLVALKKLKLTKEQAQQFYIVHKDRPFYDELCEFMSSGPIVAMVWEGENAISRIREIMGATNPEEAEEGTLRKLYGTNVGENAVHGSDSPESAKVEIPFFFSRLEIVE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPH_MYCPU
Sequence: MAIKEWIITQLSKLTKNKITEESLFSEIGIDSLDLVEHVSDLEQHFDIEISDEELLNIKKVNDIIVLIEQKSK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein homolog, ACP.
Protein: Y1621_METJA
Sequence: MPTVNILSYFAFSVEAVLFPMSSELWEKGYREALGYGVEKICLYSFVLVLPIAILMA
What are the official names of this protein?
Uncharacterized protein MJ1621.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ALD2_RHORT
Sequence: MPGSRIALRHGLIDAARQVTTLGLNKGTAGNLSVRAGDGLLITPSGLQAADLRPNDIVFIDSEGEWRGPRKPSSEWRFHHDILAERPDVGAVVHTHAPFSTVLACLGRPIPAFHYMVAMAGGNDIRIGAYATFGTAELSRHALAAMEGRKACLLAHHGMIATGRTLKAAIKLAVEVEELAEQYWRCLQIAEPEILPADEMERVLEKFKTYGDNAQLPSPPA
What is the function of this protein?
Uses 5-methylthioribulose-1-phosphate to yield 2-(methylthio)acetaldehyde and dihydroxyacetone phosphate (PubMed:29133429, PubMed:31950558).  Can also use 5-deoxyribulose 1-phosphate to yield acetaldehyde and dihydroxyacetone phosphate (PubMed:31950558).  Part of a bifunctional DHAP-shunt salvage pathway for SAM by-products (PubMed:31950558).
What are the official names of this protein?
5-methylthioribulose-1-phosphate/5-deoxyribulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family.
Protein: M2_I33A0
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVIAANIIGILHLILWILDRLFFKCIYRRFKYGLKRGPSTEGVPESMREEYRKEQQNAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single- pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: CLPP2_ALKCK
Sequence: MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSGVDDNVANSIVAQMLFLQAEDPEKDISLYINSPGGSITAGMAIYDTMQFIKPDVSTICIGMAASMGAFLLTAGAKGKRMALPNSEVMIHQPLGGMQGQAADMEIHARRIIQMREKLNQIMAERSGQPYERIARDTDRDNFMTAEQAKEYGLIDKVIETPTK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.  ClpXP2 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW.  This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_CAMJJ
Sequence: MAEHQVNYASGLPVVLTSVDKLVQWGRSNSLWALSYGLACCAIEMMAAGGSRYDFDRFGTIFRASPRHSEVMIIAGTLCKKHAEFTRRLYDQMPDPKWVISMGSCANTGGMFNTYSTVQGVDRIIPVDIYVPGCAPRPESFQFALMILQKKIRKEKASRKIAPKRLI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LYSC_DRONO
Sequence: MKFFLILGFCLLPLIAQGKVFQRCELAAAMKKHGLSNYRGYSLGHWVCAAKYESNFNTAAINRNRDGSSDYGILQINSRWWCNDGRTSGAKNLCKISCSALLSSDITASVNCAKRVVSDKNGMNAWVAWRNHCKGRDVSQWIRGCRV
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.  Has bacteriolytic activity against M. luteus.
What are the official names of this protein?
Lysozyme C, 1,4-beta-N-acetylmuramidase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRH_PSELT
Sequence: MYQRVLVKLSGEVMCGEGSRGFDQSNINYLVQQIAQIVDYGVNVGIVIGAGNIFRGEELSEIPHSLADQIGMLGTVINALYLKGSLQKVGIKCVVVSQVTSLPSIRPIHYDDINLYFDAGYVVIFAGGTSNPFFTTDTAAALRAVEMGANLLIKATKVDGIYDSDPKKNKSARKLDKISYYDAISRGLKVMDMEAFSICGRYKLPIVILNFFEDGSLLRAVRGEDVGSIIMPD
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_NATTJ
Sequence: MAISYQLEQTSSESRARLGKLKTPRGEIQTPVFMPVGTQATVKTMTPEELKNLDAEIILGNTYHLHLRPGNDIVREADGLHKFMNWDRPILTDSGGFQVFSLGKLRQISEQGVEFRSHIDGSKLFMTPEKSIEIQEDLGSDIMMVFDECPPYPAEYDYVKESMDRTIRWSKRCLQHQKHPEKQALFGIVQGGMYPELRKESALKTTELDFPGYAVGGLSVGEPKEMMLEVLNTTIPYLPEEKPRYLMGVGTPDYIIEAVRMGIDMFDCVYPTRVARNGTAMTRFGNLTVRNAVFQRDFQPIEEDCDCYVCQNYSRAYLRHLIKANEILGFRLLTWHNLFFLIKLIKELRQAIADDNFLAWRDSFYKNYQN
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NDK_CUPMC
Sequence: MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAAKMVHLSRGEAEQFYAVHKARPFFKDLVDFMVSGPVMIQALEGESAIAKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPGMNVYSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VEMP_BC279
Sequence: MYSFVSEETGTLIVNSVLLFFAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTVYVYSRVKNLNSSEGVPDLLV
What is the function of this protein?
Plays a central role in virus morphogenesis and assembly.  Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport.  Also plays a role in the induction of apoptosis.
What are the official names of this protein?
Envelope small membrane protein, E protein, sM protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses E protein family.
What are the subcellular locations of this protein?
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Protein: RUVA_METNO
Sequence: MIGKLKGVVDSYGEDFVILDVHGVGYVVHCSARTLQRLPPVGEAADLAIETHVREDMIRLYGFRSDAEREWFRLLQTVQGVGTRVALGVLSVLEPADLATAIATGDKGAIARAPGVGPRLAARLVAELKDKAPAFAPVDPALIRLAGAVEERTAPQPVADAISALVNLGYPQIQASAAVAAALQGAGEGAEAKTLIRLGLRELAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ARGB_BUCA5
Sequence: MNPLVIKLGGVLLESDDAMKRLFEALVDYQKFYKRHVSVIHGGGRLIDNLMNKLSLPVKKKNGLRITPSEHINIITGALAGTANKTLLAWALKYNINAIGLCLADGGSVDVERLDENLGHVGKAIPGSPLFLKKLFKEGTIPIISSIGITKDGLLMNVNADLAATALATTLQANLILLSDISSILDGKGQRITEIDSIQAEKLIMQGIITNGMIVKVRAALEAARVLRRPVDIASWQNTEKLKLLFNGVNIGTRVYV
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XGHA_ASPTU
Sequence: MALYRNLYLLASLGLSSAAPSKVQRAPDSSIHARAVCTPTAGGDSSTDDVPAITEALSSCGNGGTIVFPEGSTYYLNSVLDLGSCSDCDIQVEGLLKFASDTDYWSGRTAMISVSNVDGLKLRSLTGSGVIDGNGQDAWDLFASDSSYSRPTLLYITGGSNLEISGLRQKNPPNVFNSVKGGATNVVFSNLKMDANSKSDNPPKNTDGFDIGESTYVTITEVTVVNDDDCVAFKPSSNYVTVDTISCTGSHGISVGSLGKSSDDSVKNIYVTGATMINSTKAAGIKTYPSGGDHGTSTVSNVTFNDFTVDNSDYAFQIQSCYGEDDDYCEENPGNAKLTDIVVSSFSGTTSDKYDPVVANLDCGADGTCGISISGFDVKAPSGKSEVLCANTPSDLGVTCTSGASG
What is the function of this protein?
Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin.  Activity requires a galacturonic acid backbone substituted with xylose.
What are the official names of this protein?
Endo-xylogalacturonan hydrolase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRDB_LATSS
Sequence: MTSDLRVSLPGLELKNPIMPASGCFGFGQEYGRYYDLNLLGAFIIKAATKEPRLGNATPRVAETPSGMLNAIGLQNPGIEAIMAEKLPWLAERYPDLPIIANVAGNTEADYVAVCERISQAPNVHAIELNISCPNVAHGGLEFGTSPEAAATLTKACVAVSQVPVYVKLSPNVTDIRPIAKAVEAAGAAGFSLINTLVGMRIDPKTRQPILANQTGGLSGLAIKPVAIRLVHQVRSISNLPIIGMGGVATAGDALELMAAGANAIAVGTANFSEPFACPNIIKALPDELAKYDLHDFKTFAVNQEVL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRD9_HUMAN
Sequence: MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAERGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT
What is the function of this protein?
Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797).  Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797).  Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).  Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312).
What are the official names of this protein?
Bromodomain-containing protein 9, Rhabdomyosarcoma antigen MU-RMS-40.8.
Protein: RLME_METLZ
Sequence: MGSQWTKDNVYRKAMRDGYRARSAYKLIDINERFNVIRQTDNVVDLGAAPGSWLQVLKTMTEGQLCGVDLNPIIPLENVITITGDFTDPAIQAKIREAMPLVNVVVCDASPHLSGAKAYDQARVMGLNEEALNFASNLLKQGGNLVMKSFQGSDFNELLALVKEKFYSVRVIRSTATRRGSTECYIVAKNFIGDADDDRKKRE
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15B_DROME
Sequence: MVRMNVLADALKCINNAEKRGKRQVLLRPCSKVIIKFLTVMMKHGYIGEFEIVEDHRAGKIVVNLTGRLNKCGVISPRFDAPINDIEKWTNNLLPSRQFGYVVLTTSGGIMDHEEARRKHLGGKILGFFF
What are the official names of this protein?
40S ribosomal protein S15Ab.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SHC1_MOUSE
Sequence: MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLKLANPAGGRLGPKGEPGKAAEDGEGSAGAALRDSGLLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAARPTLPSAQMSSHLGATLPIGQHAAGDHEVRKQMLPPPPCPGRELFDDPSYVNIQNLDKARQAGGGAGPPNPSLNGSAPRDLFDMKPFEDALRVPPPPQSMSMAEQLQGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVDRKV
What is the function of this protein?
Signaling adapter that couples activated growth factor receptors to signaling pathways.  Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).  Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.  Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.  Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems.  Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.  Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis.  The expression of isoform p66Shc has been correlated with life span.
What are the official names of this protein?
SHC-transforming protein 1, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1.
What are the subcellular locations of this protein?
Cytoplasm. SUBCELLULAR LOCATION: [Isoform p47Shc]: Mitochondrion matrix. Note=Targeting of isoform p47Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization (By similarity). SUBCELLULAR LOCATION: [Isoform p66Shc]: Mitochondrion. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation.
Protein: GBRAP_RABIT
Sequence: MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL
What is the function of this protein?
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.  Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.  Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.  Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction.  Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation.  Involved in apoptosis.
What are the official names of this protein?
Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Endomembrane system. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity).
Protein: FPG_BURO1
Sequence: MPELPEVEVTRRGIEPFVAGRRVERVDVRTAMLRWPVPAGLAEQLRAREVLAVERRGKYLLFEVDAGWFIVHLGMTGTLRVLPAAGVPVAAKHDHIDWIFDEFVLRFRDPRRFGAVLWHPREAGDVHAHPLLASLGVEPFSPAFTGALLHARTRGRTVSVKQALLAGDMVVGVGNIYASESLFRAGIRPTTAAGKVSLPRYERLADAVRATLADAIERGGSTLRDFVGSNGESGYFQLDCFVYDRAGQPCRVCGTPVRQIVQGQRSTYFCPTCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: PYRE_METKA
Sequence: MVMNRERLAEMLLEVGALKFGDFVLSSGKRSDYYVDIKEACTHPKVLDALTDALLEVLPDGDVLAGPELGAVPLVSVLSVKAGLPMAIVRKRKKEYGTGERIVGDVRGRKVVLVDDVATTGGSLLEALEAIEEEGGEVRDAVVVVDRQEGAEEALKERGVRLSSVLTADDLRGLRDAESTARG
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.