PharMolix/UniProtQA huggingface dataset:
Protein: NS1A_HASV1
Sequence: MAYGEPYYSSKPDKDFNFGSTMARRQMTPTMVTKLPKFVRNSPQAYDWIVRGLIFPTIGKTYFQRVVVITGGLEDGTYGSFAFDGKEWVGIYPIEHLNLMSSLKLIHKANALQERLRLSQEEKATLALDVQFLQHENVRLKEMIPKPEPRKIQMKWIIMGAVLTFLSLIPGGYAHSQTNNTIFTDMIAACKYSTETLTENLDLRIKLALANITISDKLDAVRQILNFAFVPRAHWLRTVFYYIHYYEMWNIFMFVLAIGTVMRSARPGTDLVTLATSHLSGFRMAVLPTIPFHTTMTLWVMNTLMVCYYFDNLLAITLAILAPILGIIFLCFMEDSNYVSQIRGLIATAVLIAGGHACLTLTGTTTSLFVVILTCRFIRMATVFIGTRFEIRDANGKVVATVPTRIKNVAFDFFQKLKQSGVRVGVNEFVVIKPGALCVIDTPEGKGTGFFSGNDIVTAAHVVGNNTFVNVCYEGLMYEAKVRYMPEKDIAFLTCPGDLHPTARLKLSKNPDYSCVTVMAYVNEDLVVSTAAAMVHGNTLSYAVRTQDGMSGAPVCDKYGRVLAVHQTNTGYTGGAVIIDPADFHPVKAPSQVELLKEEIERLKAQLNSATENATTVVTQQPSAALEQKSVSDSDVVDLVRTAMEREMKVLRDEINGILAPFLQKKKGKTKHGRGRVRRNLRKGVKLLTEEEYRELLEKGLDRETFLDLIDRIIGERSGYPDYDDEDYYDEDDDGWGMVGDDVEFDYTEVINFDQAKPIPAPRTTKQKICPEPEVESQPLDLSQKKEKQSEYEQQVVKSTKPQQLEHEQQVVKPIKPQKSEPQPYSQTYGKAPIWESYDFDWDEDDAKFILPAPHRLTKADEIVLGSKIVKLRTIIETAIKTQNYSALPEAVFELDKAAYEAGLEGFLQRVKSKNKAPKNYKGPQKTKGPKTTTH
What is the function of this protein?
Protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.
What are the official names of this protein?
Non-structural polyprotein 1A.
What is the protein family that this protein belongs to?
Belongs to the astroviridae polyprotein 1A family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: EX7S_RHOPS
Sequence: MADAAPADVKKLSFERAMEELETIVKRLEDGKVPLEESVAIYERGEALKRRCDELLRQAEARVDKITTDAQGKPVGTEPLDVQ
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSSA_PIG
Sequence: MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPTTEDWSAAPTAQATEWVGTTTEWS
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.  Also functions as a cell surface receptor for laminin.  Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways.  May play a role in cell fate determination and tissue morphogenesis.  Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.  Acts as a PPP1R16B-dependent substrate of PPP1CA.
What are the official names of this protein?
40S ribosomal protein SA, 37 kDa laminin receptor precursor, 37LRP, 37/67 kDa laminin receptor, LRP/LR, 67 kDa laminin receptor, 67LR, Laminin receptor 1, LamR, Laminin-binding protein precursor p40, LBP/p40.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane.
Protein: YBEY_MESM1
Sequence: MENNLNLCNQTNYRFRYKKDFQNILDEIALFFKEKLPLELDLNIVDNILIKKISKQYYKKDKETDVLSFPSELANMKNALGFFHIGEIFLNYEKVILQAKEYNHSLKREFCYLFTHGIIHLYGYDHVKENEAKEMNAIVESIMQKLNIKRRK
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
Protein: RR7_PHATC
Sequence: MSRRNISKKRFPETDAIYNSYLVSLLISRILKSGKKTIAKKIVYQAFDIIKKKTNEDPLTVFEKAIRNASPIVEVKARRVGGSTYQVPVEVTGFRATNLSLRWIIRYGDQRVGRSMAIKLANEIIDTANDIGNTIKKKEETHKMAEANKAFAHFRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PYRD_ECOUT
Sequence: MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQVMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSQELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: OXR1_ASPFU
Sequence: MSSLSQGDSPSLTATASSSSSSSTSGSRTPKANNSFNQSAASYFSYPVTHVVSGLYRRLTEPNITKASRKDSNSPNRKMNARNNRDSSTTSPDIFVPIRTASPFQPPPLTPLTLTPGPGVPQQQLLTRALAEEIRLLVPARLQLVDTWRLAYSLDRDGASLSTLYEHCRDFSHRSPRAGYVLIVRDSSPAGAVFGAYMTDPPHPDSHYFGTGECFLWRASVLPSPSNLLNINGPQSEEMLERAGLPLPPSADTTHAGRSTTLRGDSRGHGDGRLAAPRANGGTGAGAASGASTPERIRFKAFPYSGVNDYMMFCETGFLSLGGG
What is the function of this protein?
May be involved in protection from oxidative damage.
What are the official names of this protein?
Oxidation resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the OXR1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL6_ECO5E
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNTLTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVINLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: TOC64_PEA
Sequence: MKSMASPSSQIWVILGLGLAGIYVLTRKLTQAVKEDFGAFLLKLKLLPPPPPAPPKAPHPLSSLNFAISDIFDIEGHVSTFGHPEWARTHEPASSTASAVSALVESGATCIGTTVVDELAYGISGENKHFGTPTNPAVPNRVPGGSSSGAAVAVAANFVDFSLGVDTSGGVRVPAGFCGILGFRPSHGAVSHVGIIPVSTSLDTVGWFAKDPDVLRRVGHILLQAPFVMQRNPRQIIIADDCFQHLNVPLDRTSQVVIKATEKLFGKQVLKHINFEDYISSKVSSLKACSIQKSNGVLKSSSLKLLANVMQSLQRHEFEHTHSEWMSIVKPDLHPAVSAQLHEKFEVSELEIENSKSVRSELRVAVNSLLKDEGVLVIPTVADPPPKLGGKEFLSHDYQSRALSLLSIASISGCCQVTVPLGFFDKNPVSVSLIARHGGDRFLLDTLKTMYTVLQEQADIAAPSKSSKSVVSKEQSAEISKEKGNQAYKDKQWQKAIGFYTEAIKLCGNNATYYSNRAQAYLELGSYLQAEEDCTTAISFDKKNVKAYFRRGTAREMLGYYKEAIDDFKYALVLEPTNKRAASSAERLRKLFQ
What is the function of this protein?
Chaperone receptor mediating Hsp90-dependent protein targeting to chloroplasts.  Bi-functional preprotein receptor acting on both sides of the membrane.
What are the official names of this protein?
Translocon at the outer membrane of chloroplasts 64.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane; Multi-pass membrane protein.
Protein: RS6_MYCTO
Sequence: MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGKVEKVDIWGKRRLAYEIAKHAEGIYVVIDVKAAPATVSELDRQLSLNESVLRTKVMRTDKH
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PAA_STRCG
Sequence: MKRKETFGFRKSKISKSLCGALLGTAIVVSVAGQRALAEDMTTSTTSAVDTTAVVGTETGNPATNLPEKQADSSSQAEASQAQAEQKTGSMPVDVATTELDEAVKSAAEAGVTVSQDETVDKGTVGTSQEADEKSGEIKADYSKQAETIKITTETYKADVAANQSETNRINQENAAKKAQYEQDLAANKAEVERITNKNAQAKADYEAKLAQYQKELAAVQQANSDNQAAYAAAKDAYEKELARVQKANADAKAAYEQAVAANTAKNEQIKAANAAIQQRNAQAKADYEAKLAQYQKDLAAVQAGNAANEADYQAKKTAYEQELARVQAANAAAKTAYEQAVAANTAKNEQIKAANTAIQQRNAQAKADYEAKLAQYQNDLAVVQAGNAANEADYQAKKTAYEQELARVQAANAAAKTAYEQAVAANTAKNEEIKAANEAIKQRNAQAKADYEAKLAQYQKDLAAVQTGNAANEADYQAKKTAYDQELARVQKANADAKAAYDQAVKDNQAKNAEIAAENAAIRQRNAAAKADYEAKLAQYQKDLAAVQKANAANEADYQAKKLAYETELARVQKANADAKAAYDQAVKDNQAKNAEIAAENAAIRQRNAAAKADYEAKLAKYQQDLTQYQKDFADYQSKLKAYEDAQAAYKAALAELEKHKNDDGYLPSPESQPFIFEQEKNATLEITSGDKVYNADEFYAEADKLDYIKADTLFNTEKRRVAYEHFKGGIQDSADWPGKRVFLPKGKPVVARYSNLKNSELNGKKIASAEFIYTLKDTSLNADKIPAMLYDDPTQTIYYFEFFGSQSIDVDIKFYDEDGNKIDATGALLDFSSLNRGHGWPQYNGINTIEKVNYHTGTAIEINGSSVKDNGDGLYAATPNYTKANQSRFESNEWDTTNSPVNWYGAIVGKQTGPDIKFTLSAENASGIWFAFDSKIKAKDIPNKPMESEPTPPVAPTQPLEPVYEVEKDLEPVPVEPNYDPEPTPPTRTPDQPEPNKPDEPNYEVEKPSEPAPIEPNYDPEPTPPTRTPDQPEPNKPDEPNYEVEQPQEPAPVEPKYDPEPTPPVDPVYEKIPDPVNVPTVRYHYYKLAIQPGVTKAIKNSDNLDIDKTLVAKQSTVKFQLLTADLPAGRPETTSFVLVDPLPSGYQFNLEATKVASPGFDTSYDEATNTVTFTATAETLANLNKDLTKTVSTIYPTIVGQVLNDGAIYTNNFTLTVNDAYGIKSNIVRVTTPGKPNDPKHPNNSYIKPHKVNKNENGVVIDGKAVLAGSTNYYELTWDLDQYKGDSSGKESIQKGFFYLEDYPEEALDLRPDLVKITDTSGKAVTGISVTDYASLEAAPEMVREMLQKANITPKGAFQLFTADNPQAFYDTYVVKGIDLTIVTPMVVKAEMGKTGGGYENRAYQIDFGNGYESNPVINNVPKIDPKKDVTLTLDPADLTNIDGQTIALNQTFNYRLIGGIIPPKHAEELFEYSFDDDYDQTGDKYTGQYKAFAKVDFTLKDGTIIKAGTDLTQYTKAQIDEVNGRILVSFKEDFLRSVSVDSAFQAEVYLQMKRIAVGTFENTYVNTVNGITYSSNTVRTSTPEPKTPEDPRTSHTVVYRPIKDKTYQPAPPQTGQLPATGDANNAYMPLLGLVSLTAGFSLLGLRRKKN
What are the official names of this protein?
Probable cell-surface antigen I/II, PAa.
What is the protein family that this protein belongs to?
Belongs to the antigen I/II family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor.
Protein: PUR8_AQUAE
Sequence: MIERYTRKEMGDVWSEVNKFKKWLDVEIAVCRAWAKLGKIPRDALKKIEEKTYVDKKVVEKIKEKEKVFKHDVLAFVSVIAEQVGEEGRYIHMGLTSSDVVDTALALLIREAIDIILKDIDKVMEEIKRLAFEHKDTLMMGRTHGVHAEPYTFGLKMCVWYDEMRRQKERLLFARENVLYGKISGAVGTYSNIPPEVEKLALEELGLKIEPASTQIVHRDRHAQLLTTLGLIASSLEKFATEIRHLQRTEVLEVLEPFTKGQRGSSAMPHKKNPIHSERICGLARVIRANSIPAMEDVVLWHERDISHSSVERVILPDSFIALDYILNLFYEILKGLVVNKERMRKNMELSKGLYASSKILVLLTQKGLSRDYAYDIVQRCAMKAWESDKTFKETLLEDPEVTKYLTEEEIEKALDPWEFLKNRDYVYEKVFGDEMG
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: RL33_METRJ
Sequence: MAKAVTVKIKLVSTADTGYFYVTKKNSRTQTEKLTMRKYDPVARKHVEFKETKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: DAPD_MYCS2
Sequence: MTAASGIGLATITADGTVLDTWFPAPELSASGPAGTARLTGDDVPADLAALTGKDEDRDVEVVAVRTTIADLNDKPADTHDVWLRLHLLSHRLTKPHEANLDGIFGLLSNVVWTNFGPCAVEGFETTRARLRKRGAVAVYGIDKFPRMVDYVTPSGVRIADADRVRLGAHLASGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVDDGSDIGGGASIMGTLSGGGKEVIKVGKRCLLGANSGLGISLGDDCVVEAGLYVTGGTKVTTADGQVTKAIELSGASNLLFRRNSLSGAVEVVKRDGTGITLNEALHAN
What is the function of this protein?
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHO1_ARTOC
Sequence: MARFQMSNLVGDPFALATVSIAILAWIITVVSCIIAQTKEAIPNFFWWSVAYQFCIVVGITAVMGSNTGHVYSTAIVGYAAAGLVCTTFTIDGLVTSKEGARQSGGAGLILLAMTDIVWIFYFGSTPQSRPRTYIDSFAPHKEQPSYRSSKPISHSYTPRPETTVSSAHQPHLYSSAPLSGFESSPMAGYNATTASSTGIQPMVGLQTNASTVGGDTAEIGQPTEYPYRAKAIYSYEANPDDANEISFTKHEILEVSDVSGRWWQAKKSTGETGIAPSNYLILL
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
What are the official names of this protein?
High osmolarity signaling protein SHO1, Osmosensor SHO1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPF_ALKEH
Sequence: MNFGATFWGPMISFALFVWFTMKYVWPPIQTAMADRQKQIADGLAAGERGQKELDQAKSEVDKMLREAREQASQVIAQANKRQSELVEQAREEARQEAERVLAQARSEIDTEISQARDALRKEVVNLAVAGSSRILKREIDAKAHKDLIDDLVKQL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PLSX_BURMS
Sequence: MTVKLTIDCMGGDHGPSVTVPAAVKFVRSHPDAHLMLVGIESAIRAQLKKCKALGEPALSVVPATEVVAMDDPVEVALRKKKDSSMRVALNHVKEGAAQACISAGNTGALMAVSRYVLKTLPGIERPAIAFALPNPTGYTMMLDLGANVDCEPQHLLQFAEMGHALVAALEGKERPTIGLLNIGEEVIKGNETIKRAGELLRASTLNFRGNVEGNDIYKGTVDVIVCDGFVGNVALKTSEGLAQMLADIIKEEFSRSLLSKLMAILALPVLLRFKKRVDHRQYNGAALLGLRSLVIKSHGSADAYAFEWAIKRGYDAVKNGVLERLSRAMAENAAPLGESGRDANGAGQASPSAGQPAEPSAALSSKT
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: AROC_METPB
Sequence: MSHNTFGHLFRVTTFGESHGVALGCVVDGCPPGLALEAEEIQAELDRRKPGQSRFTTQRREPDQVKILSGVFGDDRTGGRQLTTGTPIALMIENTDQRSKDYSEIRDSYRPGHADYTYDAKYGFRDYRGGGRSSARETAARVAAGAIARKVIPGITIRAALVQMGPHAIDRANWDWAEVGNNPFFCPDAKAAALYESYLDGIRKDGSSVGAVIEVIAEGVPPGLGAPIYGKLDADLAAAMMSINAVKGVEIGDGFAAAALRGEDNADEMRAGNDGRPRFLGNHAGGILGGISSGEPIVVRFAVKPTSSILTPRQSVNRQGEEIDLVTKGRHDPCVGIRAVPVAEAMMACVLADHHLRHRGQVGDRV
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: HOG1_CANAL
Sequence: MSADGEFTRTQIFGTVFEITNRYTELNPVGMGAFGLVCSAVDRLTGQNVAVKKVMKPFSTSVLAKRTYRELKLLKHLKHENLITLDDIFISPLEDIYFVNELQGTDLHRLLNSRPLEKQFIQYFTYQIMRGLKYIHSAGVIHRDLKPSNILINENCDLKICDFGLARLQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILAEMIEGKPLFPGKDHVHQFSIITELLGSPPADVIDTICSENTLRFVQSLPHRDPIPFSERFASCTHVEPEAIDLLAKLLVFDPKKRISAVEGLTHPYMEAYHDPTDEPVCESKFDWSFNDADLPVDTWRVMMYSEILDFHQTVGVANETEGSEQPDSQVEQNNLDSANGA
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes.  Regulates stress-induced production and accumulation of glycerol and D-arabitol.  HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program.
What are the official names of this protein?
Mitogen-activated protein kinase HOG1, MAP kinase HOG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.
Protein: MSCL_CHLPD
Sequence: MLKEFKDFAVRGNVVDMAVGIIIGAAFTTIINTLVNEVVMPPIGVLLGGVDFSDFYLLLKEGSKAAPYESLAAAKSAGAVTLSYGIFVNACISFLIVTFVMFLSVKGINRLRAKEDAAPDPAVRECPFCCSPVSVKAKRCPMCTSELK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OMA1_HUMAN
Sequence: MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS
What is the function of this protein?
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria (PubMed:20038677, PubMed:25605331, PubMed:32132706, PubMed:32132707).  Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1 (PubMed:20038677, PubMed:25275009, PubMed:32132706, PubMed:32132707).  Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (PubMed:20038677, PubMed:25275009).  Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae (PubMed:25275009).  In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome (PubMed:30733118).  May also cleave UQCC3 in response to mitochondrial depolarization (PubMed:25605331).  Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707).  Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity).  Binds cardiolipin, possibly regulating its protein turnover (By similarity).  Required for the stability of the respiratory supercomplexes (By similarity).
What are the official names of this protein?
Metalloendopeptidase OMA1, mitochondrial, Metalloprotease-related protein 1, MPRP-1, Overlapping with the m-AAA protease 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: MAGAA_HUMAN
Sequence: MPRAPKRQRCMPEEDLQSQSETQGLEGAQAPLAVEEDASSSTSTSSSFPSSFPSSSSSSSSSCYPLIPSTPEEVSADDETPNPPQSAQIACSSPSVVASLPLDQSDEGSSSQKEESPSTLQVLPDSESLPRSEIDEKVTDLVQFLLFKYQMKEPITKAEILESVIRNYEDHFPLLFSEASECMLLVFGIDVKEVDPTGHSFVLVTSLGLTYDGMLSDVQSMPKTGILILILSIVFIEGYCTPEEVIWEALNMMGLYDGMEHLIYGEPRKLLTQDWVQENYLEYRQVPGSDPARYEFLWGPRAHAEIRKMSLLKFLAKVNGSDPRSFPLWYEEALKDEEERAQDRIATTDDTTAMASASSSATGSFSYPE
What is the function of this protein?
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
What are the official names of this protein?
Melanoma-associated antigen 10, Cancer/testis antigen 1.10, CT1.10, MAGE-10 antigen.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPF2_RHOP5
Sequence: MAEGHGTTAHTGAEGGHKAPFPPFQQDTFASQLVSLLIAFVALYLIVSKVALPKVGGVLDARQKKIEDDFAAALRLKGESDDALKAYEDALAQARARAQAIGTETRERLNAAAEAERKTLEQRLAVKLADAEKTIAATREQAMSNVRGIATDAASAIVQQLVGIAPDAKAVGHAVDATLKG
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria (By similarity).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.