PharMolix/UniProtQA huggingface dataset:
Protein: MDM34_LACTC
Sequence: MSFRFNKGAFEDNSFNEQIREALTSALNSKTQSSSQTAPANTTNSAATDEVKQETRGPKRLDILKSGISVSKVNFPSTPQLEILDLDVSAQSRSLLKGICKVSCKNAMLEINTEIEANLLLLYTNDGPSFTTPRLISNDSFTVPITMTFNQIELEAITNIFVKNNSVGISFNDVNLDFDFDCSIKLLQSSIEKRLKGSMETVFKEVLPSVIFSMSQRWFTHGESTCNSASDDKSAGRQVENHSHTPRTILEDCDLEDLSPANMLRLSTLVSSRQSLSLNPTAMNTLSTIPGCLERQNLHRFNSRIPALSNFYPDFYEVESPHLKAFGRSVSTNVISSGKLEHHNALPQRVLDERSYDLKTIASVQSRIFERSSGDGTAIRRRKIKMGKKSKSKKAQSQDIENSSPTVVMPSSPSLEPSAVSTPEALHSPQPTTAVQSPELLAENSESVSIPALILPTQADHYTLPVKTSAPKLNLLEEAHYLNRKREFQKLRTSLYSPIRSNRFNLNKEMERPILEHKGLNFVGLTHGLNWGSEDLPPPYRG
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: NOP56_HUMAN
Sequence: MVLLHVLFEHAVGYALLALKEVEEISLLQPQVEESVLNLGKFHSIVRLVAFCPFASSQVALENANAVSEGVVHEDLRLLLETHLPSKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEILRGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEDKLEKLEELTMDGAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDVMKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPKKKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPKEETVNDPEEAGHRSGSKKKRKFSKEEPVSSGPEEAVGKSSSKKKKKFHKASQED
What is the function of this protein?
Involved in the early to middle stages of 60S ribosomal subunit biogenesis.  Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.  Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
What are the official names of this protein?
Nucleolar protein 56, Nucleolar protein 5A.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Nucleus, nucleoplasm.
Protein: PSA_MYCTK
Sequence: MSFPYFISPEQAMRERSELARKGIARAKSVVALAYAGGVLFVAENPSRSLQKISELYDRVGFAAAGKFNEFDNLRRGGIQFADTRGYAYDRRDVTGRQLANVYAQTLGTIFTEQAKPYEVELCVAEVAHYGETKRPELYRITYDGSIADEPHFVVMGGTTEPIANALKESYAENASLTDALRIAVAALRAGSADTSGGDQPTLGVASLEVAVLDANRPRRAFRRITGSALQALLVDQESPQSDGESSG
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_PROMP
Sequence: MKENKKTQFPINKTLSKINKKFLELKKSDKLALMPFIMAGDPNIETTSEILLKLQEKGADLIELGIPYSDPLADGPIIQLSASRALKSGTTLKNVIQLLESLKDKLHIPIILFTYFNPVLNFGLENFCELASKVGVSGLIIPDLPLEEAYKFSEIISSYSIDLILLVAPTTPSERMKIISNNTKGFTYLVSVTGVTGERNKMENRVENLITKLQEISINPVAVGFGISSPEHVNKVRKWGADGVIIGSAFVKRISNSNEKEVVNQIGKFCEEMRKAADQ
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: LIPA_CORGB
Sequence: MTIAPEGRRLLRVEARNSETPIETKPRWIRNQVKNGPEYQDMKERVAGASLHTVCQEAGCPNIHECWESREATFLIGGANCSRRCDFCMINSARPEPLDRGEPLRVAESVREMQLNYSTITGVTRDDLDDEGAWLYSEVVRKIHELNPHTGVENLVPDFSGKKDLLQEVFESRPEVFAHNVETVPRIFKRIRPAFRYERSLDVIRQARDFGLVTKSNLILGMGETKEEITEALQDLHDAGCDIITITQYLRPGPLFHPIERWVKPEEFLEHADAAKEMGFAAVMSGPLVRSSYRAGRLYAQAMEFRGEEIPAHLAHLKDTSGGSTAQEASTLLERYGASEDTPVVSFN
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUTQ_SALTY
Sequence: MSDALLNAGRQTLMLELQEASRLPERLGDDFVRAANIIIHCEGKVIVSGIGKSGHIGKKIAATLASTGTPAFFVHPAEALHGDLGMIESRDVMLFISYSGGAKELDLIIPRLEDKSVALLAMTGKLHSPLGRAAKAVLDISVEREACPMHLAPTSSTVNTLMMGDALAMAVMQARGFNEEDFARSHPAGALGARLLNNVHHLMRQGDAIPQVMLATSVMDAMLELSRTGLGLVAVCDEQHVVKGVFTDGDLRRWLVGGGALTTPVSEAMTPNGITLQAQSRAIDAKELLMKRKITAAPVVDENGKLTGAINLQDFYQAGII
What is the function of this protein?
Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P).  It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) (By similarity).
What are the official names of this protein?
Arabinose 5-phosphate isomerase GutQ, API, G-API, Phosphosugar aldol-ketol isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GutQ/KpsF subfamily.
Protein: KDGD_AZOVD
Sequence: MTPQELKSILSSGLLSFPVTDFDAAGDFDAESYARRLEWLAPYGASALFAAGGTGEFFSLGLDEYPRIIKTAVDTCAGSVPILAGVGGPTRQAIHMAQEAERLGAKGLLLLPHYLTEASQEGVAAHVEAVCRAVKIGVVVYNRNVCRLTPALLEQLAERCPNLVGYKDGLGEIELMVSVRHRLGERFAYLGGLPTAEVYAAAYKALGVPVYSSAVFNFIPRTAMEFYKAVAADDQVTVGRLIDDFFLPLLEIRNRRAGYAVSIVKAGVRVIGHDAGPVRAPLTDLLPDEYERLAALIRKLGPQ
What are the official names of this protein?
Probable 5-dehydro-4-deoxyglucarate dehydratase, 5-keto-4-deoxy-glucarate dehydratase, KDGDH.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: RS2_NOCFA
Sequence: MAVVTMKQLLDSGAHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTYIDKAYEFVKETVAHGGTVLFVGTKKQAQESIAAEATRVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEAMEQTGGFEGRTKKEILMLTREMNKLERTLGGIRDMQKVPSAIWVVDTNKEHIAVGEARKLNIPVIAILDTNCDPDLVDYPIPGNDDAIRSAALLTKVVASAVAEGVQARAGLASGDAKPEAGAGEPLAEWEQELLAQANPNAEGSAEAAPAAATEEAPAAQTPADF
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RL27_CLOD6
Sequence: MLNMNLQLLASKKGVGSSKNGRDSISKRLGVKRFDGQLVTAGSIIVRQRGTKIHPGTNVGKGSDDTLFALVDGTVKFERKDKKRKKVSIYPVAIAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RPOC2_PROM1
Sequence: MTSSSPKTRKSSTKSKAKRGSKSKKAAEIKAVQRLSKTPPPFRNKVVDKKVLKNLVAWAFKHHGTAATAAMADNLKDLGFRYATQAAVSISVDDLKVPEAKQDLLGQAEELITATEECYRLGEITEVERHTKVIDTWTETNERLVDAVKKNFNQNDPLNSVWMMANSGARGNMSQVRQLVGMRGLMANPQGEIIDLPIRTNFREGLTVTEYVISSYGARKGLVDTALRTADSGYLTRRLVDVAQDVIVREEDCGTTRSILISAEDGKFGNRLVGRLTSEQVVNADQEVLAERDTPIDPQLSKKFEQSNLQGVRVRSPLTCEATRSVCRKCYGWALAHNQLVDLGEAVGIVAAQSIGEPGTQLTMRTFHTGGVSTAETGVVRSTLSGKVEFGSKARVRGYRTPHGVEAQQAEVDFNLSIVPTSGSKPQKIDIPIGSLLFVDNGQNIDIDVTVAQIASGTVQKSVEKATKDVICDLAGQVRYETIIQPREVTDRQGNITLKAQRLGRLWVLAGDVYNLPPNALPVVSGNVSVKEGQVLAEASQASEFGGEVRLRDSIGDSREVQIVTTSMILNDFKLLEESTHSGEIWHLEAQDNTRYRLNTIPGSKIGNNEVIAELSDDRFKTETGGLIKYAPGLTIKKARSAKNGYEVSKGGTLLWIPQETHEINKDISLLMIKDRQWIEAGTEVVKDIFSQTAGIVTVTQKNDILREIIVRSGTFKLCKESKALDRFEGDGQIVNPGETIAKGIKTDSMVMVQSVETPEGKGLLLRSVEEFTIPDQAQLPELKHVKQPKGPSLGIKASQRLAYKDGELIKSVEGVELLKTQLMLETFDTTPQMTVDVEVIHDLNSKGDRLKLVILESILVRRDTTSDSSHGSTHTELQIENAQVVSAGDVVATTQILCKQEGVVQLPDAVDGDPVRRLIVERDEDTITIDSKGTTLLKVGQRVVDGDFVSKDQSIDACGEIENIDGKKVKLRLGRPYMVSPDSVLHVRDGDLVQRGDGLALLVFERQKTGDIVQGLPRIEELLEARRPRDSAILCKKSGTVDIKKGDDDDSVVVSIIEDNDVISEYPILLGRNVMVRNSQQVIAGEFLTDGPVNPHELLECFFTDLRDKKPLMDAAQEAIAKLQHRMVSEVQNVYKSQGVAIDDKHIEVIVRQMTSKVRIEDAGDTTFLPGELIELRQVEDTNQAISITGGAPSEFTPVLLGITKASLNTDSFISAASFQETTRVLTEAAIEGKSDWLRGLKENVIIGRLIPAGTGFSGFVEELNAEAGPHPDILAEDPAGYRRIQNLRPDYTVDMPSSPVAKNTAVLDDPSDEDLEATRSRHGIDPTTSNFAAFARPTGDDELSAEDQMPDPAALEGLQEEGLLSDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
Protein: RPOY_STRPZ
Sequence: MIYKVFYQETKDQSPRRESTKALYLNIDATDELDGRIKARRLVEDNTYYNVEFIELLSDKHLDYEKETGVFELTEF
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: RL4_THEKO
Sequence: MKVKVFNLEGEPVEEIELPKVFSTPFRPDLIRRAVIASWTHRIQPQGRDPQAGKRRVTENIGKGHGMARVERIKTSPRFAAFVPFAVGGRRTHPPKVEKIIWEDINKKERRLAIMSAIAATANYDLVRARGHVVDNVVQIPLVVTDDLQKVFKTAQTREIFKKLGVWDDIERAKKNTKIRAGKGKMRGRRYKKAKGPLIVVAKNEGIVQGARNHPGVDVVTVDNLGVEYLAPGTHPGRLTIWTKGAIERLREIYG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RL27_PROMH
Sequence: MAHKKAGGSTRNGRDSEAKRLGVKRFGGEAVLAGSIIVRQRGTKFHAGTNVGCGRDHTLFALADGKVKFEVKGPNNRKFISIEAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RL36_PHYAS
Sequence: MKVKASVKKRSEDDIIVRRKGRVYVINKKNRRHNQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: MRAY_HAEI8
Sequence: MLVWLAEYLVRYETAFNAISYITVRAILALLTALFISLWIGPKVIKRLQILKFGQEVRNDGPESHFAKKGTPTMGGVMILFSIGVSTLLWANLANSYIWVCLFVLFGYGAIGFVDDFRKITRKNTDGLIARWKYFWMSVVALVAILWLYWLGHDTDATRLVIPFFKDIMPQLGLFYIVLSYFVIVGTGNAVNLTDGLDGLAIMPTALVAGAFALIAWATGNVNFAEYLHIPYIKYSSEVVVFCTAIVGASLGFLWFNTYPAQVFMGDVGSLALGGALGVVAILVRQEFLLVIMGGVFVVEALSVILQVGSYKLRKQRIFRMAPIHHHFELKGWPEPRVIIRFWIISLMLVLMGLVTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL10_ACISJ
Sequence: MSLNRSEKEAVINEVTSLAAKAQTLVIAEYRGITVADMTKLRVEARSKGVSLSVLKNTLARRAVAGSQFDVVADQMTGPLIYGFSEDAVAAAKVVADFAKTNDKLVIRGGAFAGKALDVNGVKQLANIPTKEVLLAQLCGLLMSPISRTAVVLGALAAKKGEGEPAAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: YCAR_ECOSE
Sequence: MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS
What are the official names of this protein?
UPF0434 protein YcaR.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: CAZA1_PIG
Sequence: MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEVDGSLKSWRESCDSALRAYVKDHYSNGFCTVYAKNIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTVSNEAQTAKEFIKIIEHAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.  May play a role in the formation of epithelial cell junctions (By similarity).  Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (PubMed:36071160, PubMed:25814576, PubMed:29420470, PubMed:33734450).
What are the official names of this protein?
F-actin-capping protein subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: PYRF_GEOSL
Sequence: MTRDQAREKVIFALDSSEFAHVQYWAETLSDRVGMFKVGKQLFTACGPATVRMIQKFGGEVFLDLKFHDIPNTVAMASLEAARLGVKLFNLHALGGYEMMARTVEALDKEFKGGERAKVLAVTILTSSTEETLRQVGIESPVEEMVVRLATLARKAGIDGVVASPREIPLIREACGPDFLIVTPGVRPAFAALNDQKRVMTPAEAVRAGGDYLVIGRPIGDAPDPAGAAEMILDEIMAG
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: ASNS1_YEAST
Sequence: MCGIFAAFRHEDVHRYKPKALQLSKRIRHRGPDWSGNAIKNSTIFVHERLAIVGVESGAQPITSSDGEYMLCVNGEIYNHIQLREECADYEFGTLSDCEPIIPMYLKHDIDAPKYLDGMFAWTLYDAKQDRIVAARDPIGITTLYMGRSSASPKTVYFASELKCLTDDCDTITAFPPGHVYDSKTDKITRYFTPDWLDEKRIPSTPIDYMAIRHSLEKAVRKRLMAEVPYGVLLSGGLDSSLIASIAARETAKATNDVEPSTYDSKARHLAGIDDDGKLHTAGWTSLHSFAIGLPNAPDLQAARKVAKFIGSIHHEHTFTLQEGLDALDDVIYHLETYDVTTIRASTPMFLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFAQAPSAAEFHTESVQRVKNLHLADCLRANKSTMAWGLEARVPFLDREFLQLCMNIDPNEKMIKPKEGRIEKYILRKAFDTTGEPDAKPYLPEEILWRQKEQFSDGVGYSWIDGLKDTAEAVISDEMFASPKAEWGSDIPTTKEAFWYRLKFDALFPQKTVADTVMRWIPKADWGCAEDPSGRYAQIHEKHIE
What are the official names of this protein?
Asparagine synthetase [glutamine-hydrolyzing] 1, Glutamine-dependent asparagine synthetase 1.
Protein: GPMI_UREPA
Sequence: MKLNKKIGLIIIDGLGIGKEDNTNAVHLANPPTLNYLINNFPTLQISAAQQNIGLLENQAGNSEIGHLTIGAGRIILNDNANINNYMKSVDYESAVLSNIKNEIVHIVGMYSNGLVHSNYEHIHWIIKQIIKNNNQVVLHLISDGRDDYPYGFAQFIEQINALKKQYNIIVKSLSGRYFAMDRDQRWERTQKAFNAMFVKQDKICEKTFLEVAQSIANSYKSDEFVQPVVFNDDEKYNLKPHQKVILANYRSDRMRQLAHLLKPNKKFHYNNPFLVQDVNLITLVPFPDVDAIALFEKQNLNNTLGDVFNKHQIKEARIAETEKYAHISFFFDGGVNKYYSTKTQYLIPSQKVATYDLCPQMSAHLITKTIIDHYFDHDVFIVNYANPDMVGHSGNMQQTIEAILSVDHEIRKLYDFFEKNNGVLMITGDHGNAEMMLDDQKQVITSHSVNDVWFIITDNKVILNSTQKFSLANIAPTILEYLNIAQPIQMTATSMIKKICE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: ECTC_MYCSS
Sequence: MIVRTTQAITGTERDVAAKDWRSKRIVLADDGVGFSFHETTINANSVSEFHYRHHVEAVWVVEGSGTLTDHETGEEFPLLPGTMYLLDGHERHRVTCHEQLRMLCVFNPPVTGQEVHDESGAYPAPVAS
What is the function of this protein?
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
What are the official names of this protein?
L-ectoine synthase, N-acetyldiaminobutyrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the ectoine synthase family.
Protein: VE7_HPV27
Sequence: MHGTRPSLADITLILEEIPEIIDLHCDEQFDSSEEENNHQLTEPAVQAYGVVTTCCKCGRAVRLVVECGPEDIRDLEQLFLKTLNLVCPHCA
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: SGRL_ORYSJ
Sequence: MPIEAVAVASLPMASRSAALCFSSAAAARSRSRSRHGRMAVSCDAGASDLLYSSLAAKLLGPPTSFDAGKLTVEFAHSHGNSSSGFPRAYTLTHCDFTANLTLAVSDTIAADRRLRADDVFAEWKQQQQQEGMALHVHCFVSGANLLHGLAAGFRYYVFSKELPLVLKAVVHGDALLFAEQPELLEAKVWVHFHSSSNAKYNRLECWGPLREAANAETTHKRHALEQLHNAITKGTRRRRRKWSSPDAIFSALLALLL
What is the function of this protein?
Promotes chlorophyll degradation in leaves.  May be involved in LHCI proteins degradation, regulating the balance between LHCI and LHCII.
What are the official names of this protein?
Protein STAY-GREEN LIKE, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the staygreen family.
Protein: RLMH_BURO0
Sequence: MKLFILAVGHKMPGWIASGFDEYTKRMPPELRIELREIKPELRSGGRSAESVMAAERQKIEAALPKGARLVALDERGRDWTTMQLAQALPGWQQDGRDVAFVIGGADGLDPDLKARADVLLRISSMTLPHGMVRVLLAEQLYRAWSITQNHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
Protein: FXI1E_XENLA
Sequence: MSAFDPQAHSPPRCGPQFPSIGQEPPEMNIYCESFLHPQTMPSPQRPSNFETGDYSTTANPYLWLNGPSITPPPYLPGSNSSHFMPQAYGMQRQLLPNMHGLGSSELGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSPNGQLSSDKPEGSPLSESPTNGEHQDMLGNSSPGTDDSPEKRSPPPSITPCLNNFLSSMTAYVNSATPISRSVPLGLSNETSDKMGQNMVGFNSYTPLSNMPSHGGSDWSSTVSSNPFGYSSSVFNQFTPHFYNSMSTNNTLYNREGTEV
What is the function of this protein?
Transcriptional activator.  Activates ectoderm, in addition to inhibiting mesoderm and endoderm formation; required at the blastula stage for normal formation of both the central nervous system and epidermis, the two early derivatives of the ectoderm.  In addition, also required to maintain the regional identity of the animal cells of the blastula, the cells that are precursors of ectodermal structures.  Also plays a role in differential adhesion, which limits cell mixing as primary germ layers become specified.
What are the official names of this protein?
Forkhead box protein I1-ema, FoxI1-ema, Ectodermally-expressed mesendoderm antagonist, Xema, FoxI3.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL3_LIMF3
Sequence: MTKGILGKKVGMTQVFTDNGELVPVTVIDVTPNVVMQVKTLENDGYSAVQLGFDDKREVLSNKPEQGHAAKANTTPKRFIGEIRDAELGDDIKVGDKVAADIFAEGETVDVTGTTKGHGYQGNIHKDGQRRGPMAHGSRYHRRPGSLGAIINHVFKGKKLPGRMGNNTRTVQHLRIVKVDTENNVLLIKGNVPGANKSFVTIKNSVKANTKKSLSKQSNK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: AKT31_ALTAL
Sequence: MLNRFSYSSNAWHNLRVDGPDADGIAVIVLARSQSRNALTLPMLTDMVQLLSAMDADDSVKCIVFTGEGPFFCSGVDLTEGFGEIGKTRDTHRDAGGKLALAIHNCRKPTIAAINGTAVGVGITMTLPMSIRIAAKTAKISFPFVRRGIVADAASSFYLPRLVGYGRALHLFTTGALYPAESGLLHGLFSETVNPASSTLPRALEVARDIAVNASQVGVYLTRDLVYRSPRSPEQAHLLESAALYTRYQSRDFEEGVKSFLEKRKPRFQDTMREQSSEGVLERGDCVVGLASKPKL
What is the function of this protein?
Enoyl-CoA hydratase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AK-toxins responsible for Japanese pear black spot disease by the Japanese pear pathotype (PubMed:10975654, PubMed:10432635, PubMed:20348386).  AK-toxins are esters of 9,10-epoxy 8-hydroxy 9-methyldecatrienoic acid (EDA) (PubMed:22846083).  On cellular level, AK-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The acyl-CoA ligase AKT1, the hydrolase AKT2 and enoyl-CoA hydratase AKT3 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety (PubMed:10432635, PubMed:10975654, PubMed:22846083).  Part of the EDA biosynthesis occurs in the peroxisome since these 3 enzymes are localized in peroxisomes (PubMed:20348386).  The exact roles of the 3 enzymes, as well as of additional AK-toxin clusters enzymes, including AKT4, AKT6 and AKTS1, have still to be elucidated (PubMed:10432635, PubMed:10975654, PubMed:22846083).  The Cytochrome P450 monooxygenase AKT7 on the other side functions to limit production of EDA and AK-toxin, probably via the catalysis of a side reaction of EDA or its precursor (PubMed:24611558).
What are the official names of this protein?
Enoyl-CoA hydratase AKT3-1, AF-toxin biosynthesis protein 3-1.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Peroxisome. Note=The peroxisomal location requires the C-terminal tripeptide peroxisomal targeting signal.
Protein: HSLV_NITEC
Sequence: MTTIVSVRRGRQVALGGDGQVTLGAVVAKASARKVRRLYHDKVLAGFAGGTADAFTLFERFEAKLEKHQGHLLRSAVELAKDWRTDRILRRLEAMLVVADHEATLIITGAGDVIEPEQGLAAIGSGGAYAQAAARALLENTNLGPAETVAKALTIAGDICIYTNQVHVIEQLD
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.