PharMolix/UniProtQA huggingface dataset:
Protein: RS16_CORU7
Sequence: MAVKIKLQRVGKIRTPQYRVVVQDARARRGGAVIENLGIYQPANQPSIIDINSERAQYWIGVGAQPTDTALALLKLTGDWQKAKGLEGGENTVKPQPEKKSKLDIFNEALAEAAEGPTAEAITEKRRKAKEEAEAKAAAEAEAAEKAEAEAAEKAAAEAAEESEEASAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: HRCA_XYLFT
Sequence: MCASFSPTLDSRSRQLLRTLISCYIQNGEPIGSKTLAQQAGLDISPATIRNILADLEELGLLNSPHTSAGRVPTAHGYRMFVDSLVQMQPPSEDDIRRLRVEMTGGGTQTLLGSASEILSAMTHFVGVVSAPRREQFVFRHIDFVPLDARQIMAILIFADNEVQNRVIEPRRVYEPGELERVSNYLNAHFIGRTLADIRTTVLCELRKAKDEMEQLLAHSLDLASQMLVPNDSEDIVVTGQTRLMALQDLSDMDRLRELFEIFASKREILQLLERTIDAPGVRIFIGEETGMVSMEDISLVTAPYAAHGQVLGVLGVIGPKRMAYDRVIPLVQVVAQVLGTALEPPTMP
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: POTA_TRIEI
Sequence: MTQTALNIGTTLNKTKNDVELRKVFKVFEGHTAVKGVDFNIRQGEFFSILGPSGCGKTTTLRLIAGFETPSAGEIIIRGQSMSQTPAYRRPVNTVFQSYALFNHLSVKDNIAFGLRIKRLGKTETEEKVAQALQLVKMEKFADRYPNQISGGQQQRVALARALVNRPAVLLLDEPLGALDLKLRKQMQMELSNIHKDLGVTFVMVTHDQQEAMSMSDRIAVMHEGRIEQIGSPQEIYECPESPFVADFIGDTNLFQGCVEYNNNSSLVVKTDSGLNISAEYKKVNGKNGEIYGGTSVVLSVRPEKVNLSLYPPDVSENCFEGRLRNVMYMGTHVHYQVNLLSGDQMMVRQPNTERTLPNLDTPMYVYWSKQNCLALSESKS
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZTF2_CAEEL
Sequence: MNCESLLTALDVSTLLSTLSSPEKEHRRKRRRGEVANPSNTLDALVARKADDQPFEKRYLSEQEAIEGPDDEIEMKKMELDPDVSTRTCSTCGYQGKWVSEMIRHKRVHTSERPFKCRYCSRTSKWKADLIRHVAKTHGIRVVSKYSRSKVFDATNSSMDSSCSSDSDRCIISEKRTVFYRCQLCSFEDERVSVLNSHVSHLHNTSPCVCRCGAKFEDVQGALAHSNGPCSHVDMIYNVMPTYEKASPLSPCRSESSSDSGIQTDPEEEASIITSSLPTPQLGSSPLLLSPTLPVTPSFLPDIQSALLSLQPNPLMSLYLASLLQSSLLNSPTIPTSFPQIIPTTILTPSQQDEMVDVEM
What is the function of this protein?
Transcription factor (PubMed:16777607).  Represses gene expression, probably via binding to DNA consensus sequence 5'-[AT][CT]TTCC[AC][AG]-3' in promoter regions (PubMed:16777607).  May play a role in pharynx morphogenesis (PubMed:16777607).
What are the official names of this protein?
Zinc finger protein ztf-2.
Protein: 5HT3B_MOUSE
Sequence: MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNREDIENDKRAFMNDSEWQLLSVSSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSGQERPLMCLQGDSDAEESRLYLGAPRADVTESPVHQEHRVPSDTLKDFWFQFRSINNSLRTRDQIHQKEVEWLAILYRFDQLLFRIYLAVLGLYTVTLCSLWALWSRM
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.  This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses.  It is a cation-specific, but otherwise relatively nonselective, ion channel.
What are the official names of this protein?
5-hydroxytryptamine receptor 3B, 5-HT3-B, 5-HT3B, Serotonin receptor 3B.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Protein: AATR1_DICDI
Sequence: MMRSDISNQISQELNNTNINLNGKSFNDYKFKEPIKDYSRYLSLRNSTPCQLTEVEISTFLASSEILSFGAGIPSKLFFPIKELEFNFNFLGNEKVRLSKEDLDLVQQYSDSPGLPKLRNWCKSIQQRHHGLCDPNTPGKEWNLLMTPGSQHALDCLVKAFFNRGDTLIVERYTYGGMFAVTQPSGINFAACEMDSKGMIPSELDNLLSNWESTHPDLKFPKLIYMIPHGQNPTGILYDMERKEEIYKIACKFDLLIIEDDPHFFLQLDNEIVNGKRVLNKSFLSIDKEDRVIRLDTFSKFLSSGIRMGFVTTNSKLFGVIAFELNASIFHSSGLTQIALEKLLTNWGDEKFDSHVNFVQEVLIRKRRETIELLEKHLKGQVEYSVPKAGLYFWVKLLGIDCSYEFVRDVLRHHKVIFGLGISSSPNRTIKTPYIRVTFSYLEKEDGEVAFKTLSDCLKDYIKNKKIIKHDEDVTLYNNIS
What is the function of this protein?
Has aromatic amino acid transaminase activity.
What are the official names of this protein?
Aromatic amino acid aminotransferase DDB_G0272014.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP28_ASPNC
Sequence: MDGIMTNGSSEAHPPMPPPEPIERPPTPPPPPPEDSALPPPPPDTSAPPPPPEDLPPAPPPETEPKKKKVGWGTKRPAPTPLSVEELVRKKREADAAAAKPKFLSKKEREKLALEKRAQEVAATRRLKSEHASNGVDRSATHSPSVSSEGPNGDARSIPTGPRAMRNSDAAPTAPAAMRHSQSHNKNYDLAPPPPPKSMSFGLTSGKGDSRFVDEDEAAAQAALVKQRYMGADQTSNFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQHRHETNFFGRGRLAGFGDDVAESVAHKYARALEDRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWDESNLPKRLMELINRVGYKEPTPIQRAAIPIAMQNRDLIGVAVTGSGKTAAFLLPLLCYIAELPRIDEFEWRKADGPYAIVLAPTRELAQQIEIEAKKFTGPLGFNVVSIVGGHSLEEQAYSLRDGAEIIIATPGRLVDCIERRILVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVSNEKPDSEDAENPLAMSRHINHDQHRYRQTMMYTATMPTAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLGDILSSGEFRAPIIVFVNIKRNCDAIAREIKQWGFSSVTLHGSKTQDQREAALASVRNGTTDVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSPISRVPEELRKHEAAQSKPTRGFSSKKNNEEGGGGGKVGW
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA splicing.  May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site.  May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing ATP-dependent RNA helicase prp28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DAPF_ACTPJ
Sequence: MQFSKMHGLGNDFMVIDGVTQNVYLTEEVIRKLADRHRGVGFDQLLLVEPPYDPELDFHYRIFNADGSEVAQCGNGARCFARFVTLKGLTNKQDIHVSTAKGKMVLTLKDEEKVRVNMGEPIWEPAQVPFTANKFEKNYILRTDLQTVLCGVVSMGNPHCVLQVEDINLTPVNELGPLLENHERFPERANIGFMQVVNRNHIKLRVFERGAGETQACGSGACGAVAVGIMQGVLDNNVQVDLSGGSLQIEWEGVGHPLYMTGDATHIYDGFIKL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLCT_STAAT
Sequence: MGEYIVTKTLNNNVVVCTNNDQEVILIGKGIGFNKKEGMALNDQTITIEKIYKLESEQQKAHYKSLVEIADDNVLQVIIDSLNFISNTAMNVDSKQLVVSLTDHIIFAYKRLKQNQVISNPFVMETMQLYSDAYHIAKQVIDQLNAALDVHFPEDEIGFIALHIASNTEDLSMHEMTLINNVIKKGIDIIESDLVTTVDKESLQYQRFIRHVQFLIRRLRRKEYIHAQDDFVSMIKNHYPICYNTAYKILTMIQKQFDVNISESEIIYLTLHIHHFEERINQS
What are the official names of this protein?
Protein GlcT.
What is the protein family that this protein belongs to?
Belongs to the transcriptional antiterminator BglG family. GlcT subfamily.
Protein: YJGA_SHISS
Sequence: MTKQPEDWLDDVPGDDIEDEDDEIIWVSKSEIKRDAEELKRLGAEIVDLGKNALDKIPLDADLRAAIELAQRIKMEGRRRQLQLIGKMLRQRDVEPIRQALDKLKNRHNQQVVLFHKLENLRDRLIDQGDDAIAEVLNLWPDADRQQLRTLIRNAKKEKEGNKPPKSARQIFQYLRELAENEG
What are the official names of this protein?
UPF0307 protein YjgA.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: ENGB_STRT1
Sequence: MTEEQVLNTHNAEILLSAANKSHYPQDDLPEVALAGRSNVGKSSFINTLLGRKNLARTSGKPGKTQLLNFYNIDDKLRFVDVPGYGYARVSKKERAKWGKMIEEYLVTRDNLRVVVSLVDLRHEPTQDDIQMYEFLKYYEIPVIVVATKADKIPRGKWNKHESIIKKKLNFDKNDHFIVFSSVTRDGYDEAWDTILAEL
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: LPPK_MYCTO
Sequence: MRRNIRVTLGAATIVAALGLSGCSHPEFKRSSPPAPSLPPVTSSPLEAAPITPLPAPEALIDVLSRLADPAVPGTNKVQLIEGATPENAAALDRFTTALRDGSYLPMTFAANDIAWSDNKPSDVMATVVVTTAHPDNREFTFPMEFVSFKGGWQLSRQTAEMLLAMGNSPDSTPSATSPAPAPSPTPPG
What are the official names of this protein?
Putative lipoprotein LppK.
What is the protein family that this protein belongs to?
Belongs to the MTB12 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PARD_YERE8
Sequence: MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Neutralizes the effect of toxin ParE (By similarity).
What are the official names of this protein?
Antitoxin ParD.
What is the protein family that this protein belongs to?
Belongs to the ParD antitoxin family.
Protein: DAPD_SULNB
Sequence: MAIETVASTDAFKVLVAEVTAQEGYREPMAFGIARVDRGQKNAEKVLQANFPLINWKENFGSAAVFIKALQEAKCDVDFSGSEFVATINDNFVANAMAAFAPYLAEATGDSHKNVQVIKTLAKMEDIGKNFRIVFLFEDANPESVEAVYLKLYALSLRKAELRKVNLNGAFGILSNVAWVGNTPYELDYLRENEIEMKLNGTYPTVDSVDKFPRFLQHVIPDDNTRILEASKVRMGAQLAAGTTVMPGASYINFNAGTLGPVMVEGRISSSAIVGAGSDVGGGASILGVLSGTDGNPISIGENTLLGANSVTGLPLGDGCIVDAGITILAGTKIKIAPEELEKIKAANPDAKLDNKTTFKGEELQGLNGIHYRQNSLTGEIIARRSTREVKLNEDLH
What is the function of this protein?
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NACB_PICST
Sequence: MPVDPEKLAKLQKAAAKKVGGSRVKAKKVVKTEQDDTKLIEALGKLKATKIENVEEANFFREDGKVLHFNRVGVQGAAASNTFAFTGYPQEKNVTQLIPQILPQLGAENLEILRQLAEQLQAGKAPTELNAGAPAGGDEGIPDLIDGEKFDEVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: PYRD1_PONAB
Sequence: MEAARPPTTAGKFVVVGGGIAGVTCAEQLATHFPSEDILLVTASPVIKAVTNFKQISKILEEFDVEEQSSTMLEKRFPNIKVIESGVKQLKSEEHCIVTEDGNQHVYKKLCLCAGAKPKLICEGNPYVLGIRDTDSAQEFQKQLIKAKRIMIIGNGGIALELVYEIEGCEVIWAIKDKAIGNTFFDAGAAEFLTSKLIAEKSEAKIAHKRTRYTTEGRKKEARSKCKSDNVGSALGPDWHEGLNLKGTKEFSHKIHLETMCEVKKIYLQDEFRILKKKSFSFPRDHKSVTTDTEMWPVYVELTNEKIYGCDFIVSATGVTPNVEPFLHGNSFELGEDGGLKVDDHMHTSLPDVYAAGDICTTAWQLSPVWQQMRLWTQARQMGWYAAKCMAAASSGDSIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGSDHELMLRCTKGQEYVKVVMQNGRMMGAVLIGETDLEETFENLILNQMNLSSYGEDLLDPNIDIEDYFD
What is the function of this protein?
Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity).  Required for normal sarcomere structure and muscle fiber integrity (By similarity).
What are the official names of this protein?
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, myofibril, sarcomere.
Protein: HEM1_FUSNN
Sequence: MLDLENIIVIGVSHENLSLLERENFMRTRPKYIIERLYTEKKINAYINLSTCLRTEFYIELNSNIKAKEIKNLFSVDMIVKSRVEAIEYLFKVGCGFYSVIKGEDQILAQVKGAYAEALENEHSSKFLNIIFNKSIELGKKFRTKSMIAHNALSLEAISLKFIKSKFPNIEDKNIFILGIGELAQDILTLLTKEQLKNIYIANRTYHKAEQIKKEFDIVNIVDYREKYPKMIEADVIISATSAPHIVVEYDKFVAQMKENKDYLFIDLAVPRDVDERLANFKNIEIYNLDDIWEVYHLNSMNRDKLLEDYSYLIDEQMEKLIKTLNYYK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: HUTH_STAA8
Sequence: MTLYLDGETLTIEDIKSFLQQQSKIEIIDDALERVKKSRAVVERIIENEETVYGITTGFGLFSDVRIDPTQYNELQVNLIRSHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVRQLQFFINERIIPIIPQQGSLGASGDLAPLSHLALALIGEGKVLYRGEEKDSDDVLRELNRQPLNLQAKEGLALINGTQAMTAQGVISYIEAEDLGYQSEWIAALTHQSLNGIIDAYRHDVHAVRNFQEQINVAARMRDWLEGSTLTTRQSEIRVQDAYTLRCIPQIHGASFQVFNYVKQQLEFEMNAANDNPLIFEEANETFVISGGNFHGQPIAFALDHLKLGVSELANVSERRLERLVNPQLNGDLPAFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSITSSANQEDHVSMGTTAARHGYQIIENARRVLAIECVIALQAAELKGVEGLSPKTRRKYDEFRSIVPSITHDRQFHKDIEAVAQYLKQSIYQTTACH
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_ROTHT
Sequence: MGKYNLILSEYLSFVYNSQSAVQIPIYYSSNSELEKRCIEFHAKCVDSSKKGMSLKPLFEEYKDVIDNATLLSLLSYSYDKYNAVERKLVNYAKGKPLEADLTANELDYENNKITSELFQSAEEYTDSLMDPAILTSLSSNLNAVMFWLERHSNDVADANKIYKRRLDLFTIVASTINKYGVPRHNEKYRYEYEVMKDKPYYLVTWANSSIEMLMSVFSHEDYLIAKELIILSYSNRSTLAKLVSSPMSILVALIDINGTFITNEELELEFSDKYVKAIVPDQIFDELQEMIDNMRKAGLVDIPKMIQEWLVDCSLEKFTLMSKIYSWSFHVGFRKQKMIDAALDQLKTEYTEDVDSEMYNEYTMLIRDEIVKMLEVPVKHDDHLLRDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDIAHGRYTPGVIPSVSVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLSYAKHTREYAEFYSQSNQLLSYGDVTRFLSSNSMVLYTDVSQWDSSQHNTQPFRKGIIMGLDILSNMTNDPKVVQTLNLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRIANKYSFITKIIRVDGDDNYAVLQFNTDVTKQMVQDVSNDVRYIYSRMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYSNYIVNKLRGFETDREFILTKIIQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRTFMSLSNQKSGIADEIASSQTFKNYVNKLSDQLLVSKNVIVSKGIAVTEKAKLNSYAPVYLEKRRAQISALLTMLQKPVSFKSNKITINDILRDIKPFFVTSEANLSIQYRKFMPTLPDNVQYVIQCIGSRTYQIEDSGSKSSISKLISKYSVYKPSIEELYKVISLREQEIQLYLVSLGVPPVDAGTYVGSRIYSQDKYKILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEIINYAIKNGTWISLFCNYPKSEMIKLWKKMWNITALRSPYTNANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).
Protein: IF1_AQUAE
Sequence: MGKKKRKQEHEKERGILLEGEVVEALPNGMFRVKLETGQEVLAHIAGKLRVNFIRILPGDKVKVELSPYDLTRGRIVYRL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_BLOFL
Sequence: MIRNQYYGTGRRKSASARVFLRFGNGDIVINNLSLDKYFPKDNFQIIIKKPLEVTNVLNILDAYITVIGGGVSGQAGAISHGITRALLQYNAEFKSVLRATGLMTRDSRMVERKKVGLRKARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: UL96_HCMVM
Sequence: MTSVNKQLLKDVMRVDLERQQHQFLRRTYGPQHRLTTQQALTVMRVAAREQTRYSQRTTQCVAAHLLEQRAAVQQELQRARQLQSGNVDDALDSLTELKDTVDDVRATLVDSVSATCDLDLEVDDAV
What are the official names of this protein?
Protein UL96.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL96 family.
What are the subcellular locations of this protein?
Virion.
Protein: RHLB_SALPK
Sequence: MSKTHLTEQKFSDFALHPQVVEALEKKGFYNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTSTFHYLLSHPAIDDRKVNQPRALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMYDLGFIKDIRWLFRRVPPAAQRLNMLFSATLSYRVRELAFEQMNNAEYVEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEDIWGHLAADGHRVGLLTGDVAQKKRLRILDEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIESYIGHSIPVSKYNPEALMNDLPKPLRLTRSRPGNGPRRAGAPRNRRRSG
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPG_RICRO
Sequence: MIQEKKKFDAEVGKILNLMIHSLYSNKEIFMRELISNASDACDKLRYLSQSNSELVAGDSNFKITVKVDKDNGQIIIRDNGIGMNKDDLIENLGTIARSGTANFLKSLSGDSKKDNMLIGQFGVGFYSSFMVADKVTVTSRKAGEDKVHIWESDGLGEYTVSDSDKEFTRGTEIILHIKKEEDTFLDHFRLKHIVKSYSDHIAVPIYFFDEAGNNEIQLNSASALWTRPKSEITEEQYKEFYKSLSYAIDDPWITMHNKNEGAIEFTNLLFIPSSKTFDLFHPDRKRRVKLYIKRVFISDENIDLIPSYLRFLRGVVDSEDLPLNISRESLQHNSVLEKIKNAITKRVLGELRKKKEESPEEYNKFWANFGGALKEGLCEATTNHEKLLEVCIFRSALHNKMISLDEYIANFKEGQSTIYYLSGDNPDKLLSSPQIEGLLSKKIDVLLFTDTVDDFWVNVNSKYKEHAIKSATRSDIDVEQTTSQSEAKNTDSKKSDDEYKLLTDYFKETLGELVKEVKISKKLTSSPACLAVSDAAMDIRMERFLIEQKQIANASAKNLELNPKNKIIEKIFNDLKANNKNNEELVNLIFDQACILEGEPVADTGAFSKRLNDIVQKAIL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTLI_BORPE
Sequence: MIHAHSNARLLRWAILAIAPVTLGACAPNGPPGLPYPDGKPLIPINTAAPEQGSSCQTRAP
What is the function of this protein?
Component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (PTX) through the outer membrane.
What are the official names of this protein?
Type IV secretion system protein PtlI, Pertussis toxin liberation protein I.
Protein: THII_STAA3
Sequence: MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTIEAISAAAIKFAQQFEENSTFKIDVKRADKNFPMDTYELQRELGGAVLKHFDNISVNVKRPDHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGALAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_FUSNN
Sequence: MEKYFDRLEKEPLIAERWKKIEELESYGIKPFGKKYDKQIMIGDILKHKPEENLKFKTAGRIMSLRGKGKVYFAHIEDQSGKIQIYIKKDELGEEQFDHIVKMLNVGDIIGLEGELFITHTEELTLRVKSIALLTKNVRSLPEKYHGLTDVEIRYRKRYVDLIMNPEVRETFIKRTKIIKAIRKYLDDRGFLEVETPIMHPILGGAAAKPFITHHNTLNIDLFLRIAPELYLKKLIVGGFERVYDLNRNFRNEGISTRHNPEFTMVELYQAHADFNDMMDLCEGIISSVCQEINGTTDIEYDGVQLSLKNFNRVHMVDMIKEVTGVDFWKEMTFEEAKKLAKEHHVEVADHMNSVGHIINEFFEQKCEEKVIQPTFVYGHPVEISPLAKRNEDNPNFTDRFELFINKREYANAFTELNDPADQRGRFEAQVEEAMRGNEEATPEIDESFVEALEYGLPPTGGMGIGIDRLVMLLTGAPSIRDVILFPQMKPRD
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_PROMT
Sequence: MTNCTVLDWQGKEAGESSIDLKTAKESSAADLLHRAVLRQQAHSRQGTASTLTRSEVRGGGRKPYKQKGTGRARQGSIRTPLRPGGGIIFGPKPRKYNLEMNRKERRLALRTALMSRIPDAKIIKDFGSKLEVPKTSEIVALLKRVGIDSDVKILIILNKPSEIIKRSIKNLEKVKLISADQLNVFDLLNANSLVIGEDALSTIKEVYGND
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.