PharMolix/UniProtQA huggingface dataset:
Protein: RL16_PROM3
Sequence: MLSPKRVKFRKQQRGRMRGVATRGNTIAFGEFALQAQECGWITSRQIEASRRAMTRYVKRGGKIWIRIFPDKPVTMRPAETRMGSGKGNPEFWVAVIKPGRILFEMGGEEITEEIAREAMRLAQYKLPIKTKFIGLDDQEKVAGSDKPASVPAITAES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: YDM6_SCHPO
Sequence: MARKGKVNTLPQPQGKHQRKGKKQLENKILHSYEEESAGFDSEELEDNDEQGYSFGVNSEDDEEIDSDEAFDEEDEKRFADWSFNASKSGKSNKDHKNLNNTKEISLNEEDDSDDSVNSDKLENEGSVGSSIDENELVDLDTLLDNDQPEKNESNTASTIRPPWIGNNDHATDKENLLESDASSSNDSESELTDSADNMNESDSESEIESSDSDHDDGENSDSKLDNLRNYIVSLNQKRKKDEADAESVLSSDDNDSIEEISIKKVKYDPHETNKESEYNLIGSSEKTIDITDLLDSIPMNEQLKVSLKPLVSESSSISSKKLDAPLAKSIQDRLERQAAYEQTKNDLEKWKPIVADNRKSDQLIFPMNETARPVPSNNGLASSFEPRTESERKMHQALLDAGLENESALKKQEELALNKLSVEEVAERTRQLRFMRELMFREERKAKRVAKIKSKTYRKIRKNRKEKEMALIPKSEEDLENERIKSEEARALERMTQRHKNTSSWTRKMLERASHGEGTREAVNEQIRKGDELMQRIHGKEISEMDGEDVSEFSDSDYDTNEQVSTAFEKIRNEEEPKLKGVLGMKFMRDASNRQKALVQDEMQAFEDELAGVPNEDDTSQKGEDGVPGVLIGNNTGRRSFKPSEEAAKLSLPSRKNPFVSDSAVLKVNKPEMKEGQKKAEARKKKESPLEATEETNPWLQVPDQRTSSAKKLDKNSSKADKKNHKLKMDKVASLQELVEEPKVQPDLIFEEKAFESASEAESDVDVSVPMLKPTKGRLSIKQRELVAKAFAGDDVVAEFEKDKEDWVQEDAPKEEDHSLPGWGSWGGVGVKQRKTKPKVKKIAGLDPSKRKDSKLKHVIINEKRNKKAAKLTADSVPFPFESREQYERSLNLPMGPEWTTRASHHKAVAPRVVTKRGKVINPIKAPN
What are the official names of this protein?
Uncharacterized protein C57A7.06.
What is the protein family that this protein belongs to?
To yeast YML093w.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: YQGF_LISMC
Sequence: MRIMGLDVGSKTVGVAISDPLGWTAQGVETIQIDENRKQFGYDRVKELVLEYEVEKVVVGLPKNMNNTIGPRAESSKIYAEVLESRIGLPVVLWDERLTTSAAERTLIEADVSRKKRKEVIDKLAAVMILQSYLDTTN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IAPP_LEPEU
Sequence: TQRLANFLIHSSNNFGAIFSPPN
What is the function of this protein?
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
What are the official names of this protein?
Islet amyloid polypeptide, Amylin.
What is the protein family that this protein belongs to?
Belongs to the calcitonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARNT_PSEAE
Sequence: MSRRQTCSLLLIAFGLFYLVPLSNHGLWIPDETRYAQISQAMLLGGDWVSPHFLGLRYFEKPVAGYWMIALGQAVFGENLFGVRIASVVATALSVLLAYLLARRLWRDPRTSLACALLYASFGLIAGQSGYANLDPQFTFWVNLSLVALWHALDAGSRRARLLGWTLLGLACGMGFLTKGFLAWLLPVLVALPYMLWQRRWRELLGYGALAVLAALLVCLPWALAVHAREADYWRFFFWHEHIRRFAGEDAQHSRPWWFYLPLLAVACLPWSGLLPSALRQAWHERRQAPVVFLALWLLLPLAFFSLSRGKLPTYIMPCLLPLALLMGHALVQRLRLGNSVALRGNGLLNLGLALLALAALAYLQLRKPVYQEEPFELFLVLLVIGAWAAAGLAQWRYPLRAWAAPLLASWVLIALLPAAMPNHVVQNKTPDLFVAEHLDELTGARHLLSNDLGAASALAWRLRRSDVTLYDTRGELKYGLSYPEHSQRSVPLADIRQWLWRARQDGSIAVLLRINSASDRYQLALLPGDGERYRNGNLVLAILPQVRP
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YPZ5_METTF
Sequence: MRNGTLLLAALLAVFILAGSSAAADVGVELDKNNTKPVYNSTLRVKVIAKAGNQNVQNAVATVKVPEGLVLQDYYTAQGYYDLETGTWEIGDIPAYEERSLTLVCLLNRTGNVTVTANVTADGDENPANNNAQLKFRVRGIADLELNVTSSKQSARLGDTVTFNVKLKNRGPHAANNINVANFFSGGLAIQSYSYTTGYFDDVAREWILETLDTGEEATLTVVCLVNRTGDLSDYVSVREVDEGDVNVYNNIARASVAVKGTDLDLDLSVSKPRAYQGDVVNVVCRVKNNGPEAAQNARVNLQLPANLQVQNVQVDRGTYSNGVWVIGDLADNEAALLNITARVVSAGNFTVNATAVSPAIDDSNPVNNDDTALVSAAIPKKALKVRIKNNSAVTIRVLLYVNINDHGKITRKTYNFYLKNGLSRDLSLGYFQLGTSALFKQYTYNTNYRPRTVSYENTYNATSVITQRVNVSGVKGRQKAPVVRIATLLLDENGTSLQ
What are the official names of this protein?
Uncharacterized protein ORF5'.
Protein: SODC_DROYA
Sequence: MVVKAVCVINGDAKGTVFFEQESSETPVKVSGEVCGLAKGLHGFHVHEFGDNTNGCMSSGPHFNPYGKEHGAPVDENRHLGDLGNIEATGDCPTKVSITDSKITLFGADSIIGRTVVVHADADDLGKGGHELSKSTGNAGARIGCGVIGIAKV
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn], Superoxide dismutase 1.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_SULAC
Sequence: MEMHPWLPNLKYTEEMLKEIGVNDIMNLFSDVPQDLILKRKLNIPYDKPLSEYEISQRLNELKKKNLELKYPPFIGGGLCPHYIPEAVKFIMSRSEFYTAYTPYQPEISQGLLQAIYEYQSLMAELLEMEFVNASMYDWASAIAEAVLMAHRINRRKSVLLPSNMNPYHREVVKTWVYGKGIRITELPTDSTSGQIDIEKLEQINTDDVSAIYIQQPNFYGIFEENIEYIVDFAKKKNIITIMGVSPLSLGLIKPPGEYGIDIAVGDGQEIGLPLNYGGPLMGIFAVRWDSQLVRQMPGRIVGLTKDEKGNRAFTLILQTREQFTRREKATSNITTNETLMAIGSAVYLSLLGKHGLRDLAEEIYVRSHYAKKKFEELGFKSPYSGEFFEEFVIQFPKNYNLIHSSLLNKRIHGGLQLNDYCALFCFTEVHTRVMIDELVKSIAEVL
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: MURC_SALNS
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIDDDAILRALESFQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKLKPQIQEEEQHG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_COXB1
Sequence: MSTLRVLHEKSELGKTTVYPKEYTPHLLLPIPRDLNRKTLNVNVSEPPPFYGYDLWNAYELSWLNEKGKPFAARGEFIIPATSSHLIESKSFKLYLNSFNNERFADAAAVSQTMKRDLSKRVNESVTVNFILHETEIPVAYSPKGSLLDVLDIAIDTYSPDPNLLSTSQETVTETLYSHLLKSNCPVTGQPDWGSIEIHYTGPKIDHAQLLKYIISYRNHEEFHEACVERFFMDILRHCRPQELTVQARYTRRGGLDINPYRSTNPTFSVQNHRSFRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABD_MYCTU
Sequence: MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLGTTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAGKDVIVAGHSVGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETEVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRALGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTLVSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKRELRGVPARAVKSPADLDELANL
What are the official names of this protein?
Malonyl CoA-acyl carrier protein transacylase, MCT.
What is the protein family that this protein belongs to?
Belongs to the FabD family.
Protein: KADA_SULIA
Sequence: MKIGIVTGIPGVGKTTVLSFADKILTEKGIPHKIANYGDYMLNTALKEGYVNSRDEIRKLQIEKQRELQALAARRIVEDLSLLGDEGIGLIDTHAVIRTPAGYLPGLPRHVIEVLSPKVIFLLEADPRIILERQKRDNSRARADYSDTTVINEVIQFARYSAMASAVLVGASVKVVINQEGDPSIAASDIINSLM
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase.
What is the protein family that this protein belongs to?
Belongs to the archaeal adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTRC_METMA
Sequence: MSAGGAGGEAKGAYPQQTLMALGIVGGLVGIYLGHFMPPAYSFFGGIGAICATVWGADAVRRVASYGLGTGVPSIGMLALGMGILAALFGLALGGIAGPILAVVVAAIIGGVIGALANKVIGMGIPIMEQAMIEISCAGTLVILGLSVVIAGSFDYAAIIENVIANGYIALIFIIGGMGILHPFNACLGPDESQDRTLILAVEKAAIALIITGFASSLHEGLMTAGINILVGLVIWYVAFSKYYALIKRDAYAVVGTGLLPSAEELQ
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit C, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit C.
What is the protein family that this protein belongs to?
Belongs to the MtrC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MPRB_MYCVP
Sequence: MAADNAGRWPGQPPGPPAPTHPASSVSLRWRVMLLAMSMVVISVVLMAVAVFAVTSRALYDDIDNQLRSRAQMLIESRSLDIDPGKAIEGTAYSDMNAMFYIPGRSKYTANQQGQTLPVGQPEQDVMDGTLLLSLRTVEHQRVLAIRLASGNTLLLSKSLAPTGKVLKRLGTVLLIVGGLGVAVAAIAGGMVASAGLRPVGRLTQAAERVARTDDLRPIPVIGNDELARLTETFNMMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMESMKPGAPRIPEEDMAELRTDVIAQIEEMSTLVGDLVDLTRDDAGNAVHETVEITEVIDRSLERVRRRRNDIQFDVAVTPWQVYGDAAGLGRAVLNLLDNAAKWSPPGGRVGVGLTQIDALHAELVVSDRGPGIPPQERALVFERFFRSTSARSMPGSGLGLAIVKQVVLKHGGTLRIEDTVPGGTPPGTAMHVVLPGRPSPAGSDEAER
What is the function of this protein?
Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host.  In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity).
What are the official names of this protein?
Signal transduction histidine-protein kinase/phosphatase MprB, Mycobacterial persistence regulator B.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: T184C_BOVIN
Sequence: MPCTCTWRNWRQWIRPLAVVLYLLSIVVAVPLCVWELQKLEVGIHTKAWFIAGIFLLLTIPISLWVILQHLVHYTQPELQKPIIRILWMVPIYSLDSWIALKYPSIAIYVDTCRECYEAYVIYNFMGFLTNYLTNRYPNLVLIIEAKDQQKHFPPLCCCPPWTMGEVLLFRCKLGVLQYTVVRPFTTIIALVCELLDIYDEGNFSFSNAWTYLVIINNMSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQAVVIALLVKVGVISEKHTWEWQTVEAVATGLQDFIICIEMFLAAIAHHYTFSYKPYVQEAEEGSCFDSFLAMWDVSDIRDDISEQVRHVGRTVMGHPRKKFFPEDQDQNEHTSLLSSSSQDALSVASSVPPSPVGHYQGFGHTVTPQTTPTTANASDDTGNDAAGVREEPSEKPVAS
What is the function of this protein?
Possible tumor suppressor which may play a role in cell growth.
What are the official names of this protein?
Transmembrane protein 184C, Transmembrane protein 34.
What is the protein family that this protein belongs to?
Belongs to the TMEM184 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HISX_PROM9
Sequence: MGREPFNLKNLEMRIINNKKDAIQELKRISSRTNSENNNKINLIVEEILQEVKTYGDIAVEKYTKKFDGFNPDPMQISEDHLKDAWDEIDSNLKRSLEVAHKRIKKFHEKEIPQSFTIKGEHGDTVQRRWRPVKNAGIYIPGGRAAYPSTVLMNAIPAKVAGVEEIIMVSPGNKEGEINKTVLAAAHLSGIKKVFRIGGAQAIGALAFGTNQINKVDVITGPGNIYVTTAKKLIYGSTGIDSLAGPSEILVIADETAQSTHIASDLLAQAEHDPLASSILLTTSKNQAKEVLEELYKKIDDHPRKEICMQSIKNWGLIVICENYELCIELSNNFAPEHLEILALDSKKILEGIENAGAIFLGKWTPEAVGDYLAGPNHTLPTSGNSRFSGSLGVETFMKNTSIIEFNEESLKVNSLDIINLAESEGLHSHANSVKIRFED
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: RFX8_HUMAN
Sequence: MAEGVPASPSSGEGSRGPHSGVIQWLVDNFCICEECSVPRCLMYEIYVETCGQNTENQVNPATFGKLVRLVFPDLGTRRLGTRGSARYHYDGICIKKSSFFYAQYCYLIGEKRYHSGDAIAFEKSTNYNSIIQQEATCEDHSPMKTDPVGSPLSEFRRCPFLEQEQAKKYSCNMMAFLADEYCNYCRDILRNVEDLLTSFWKSLQQDTVMLMSLPDVCQLFKCYDVQLYKGIEDVLLHDFLEDVSIQYLKSVQLFSKKFKLWLLNALEGVPALLQISKLKEVTLFVKRLRRKTYLSNMAKTMRMVLKSKRRVSVLKSDLQAIINQGTLATSKKALASDRSGADELENNPEMKCLRNLISLLGTSTDLRVFLSCLSSHLQAFVFQTSRSKEEFTKLAASFQLRWNLLLTAVSKAMTLCHRDSFGSWHLFHLLLLEYMIHILQSCLEEEEEEEDMGTVKEMLPDDPTLGQPDQALFHSLNSSLSQACASPSMEPLGVMPTHMGQGRYPVGVSNMVLRILGFLVDTAMGNKLIQVLLEDETTESAVKLSLPMGQEALITLKDGQQFVIQISDVPQSSEDIYFRENNANV
What is the function of this protein?
May be a transcription factor.
What are the official names of this protein?
DNA-binding protein RFX8, Regulatory factor X 8.
What is the protein family that this protein belongs to?
Belongs to the RFX family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLNE_BIFLS
Sequence: MESSMFKPSSMDLIRAGLQDLDRARALFGQLKADAIADGRCAELLGVLAHACDPDVALGNFVDIVNAMQSSRRDLDRVIPDAGALRRLITVLGASDAMGKFMRFRPELVEAASVGSADSHLFNRAQRRARLLMAVGADPDDQAMPVASKDLAEAATALRAGYRRQLAAIIAQDVMAEDPIRIQPTISSELSDLADAALEGALAIARHETEGNEHVRFTIIGMGKLGAQELNYVSDVDLIYVVEPADKDVDHQTLIRVGTKMGTMLQRVCQSVIMGVAEQPLWQIDGGLRPEGKDGALVRVLSSHKNYYEQWAENWEFQALLKARPVAGDPDLGQAYMDMSRPFVWSASKRKNFVYDCQKMRKRVEDLIPAPLKDREIKLGRGGLRDVEFTVQMLQLVHGRTDESLRTSNTLDSLQRLSEGGYVSRKQAVRMSQDYRFERVMEHRQQIWSLKRTHLFPDLGRASVGGLEKKRDIDVDELNQNQELRRLARAFGLHPEELVDKYDDTRREVRHLHLDIYYRPMLPVNAQMENDQIVLSVEAAQERFESIGFGDPDAAIRHVQALTAGVGRAAKINRIILPAVLQWLGEGQNPDMGLLNWRKLEENFGTESGYLGFLRDSTSAAQRLCHILSNSRFLGDALNKSVESISWLGDDGNLQARTREALDVQTGSALERFGSNINEFATSMRAMRRHEIERIGLSWMSGVISDSDSLKAMTDVYDAIIDASLTWAVRHQIAAFGVETAPAGITVIAMGRYGGREVNFSSDADAILIYRPADDADDGQANAFAKKVVEDLRNILQGPTTLEPKIELDLDLRPEGKNGPLVRSYASCEEYYESWASTWERQALLRARYAAGDAELARDFLINIADPLRYPTAELTEAELQNIRKLKARMEAERLPRGVRRERHLKLGKGGLSDVEWTVQLMQLQHAGDIKDLRVNGTLEALDVLEAKKLISAIDAIQLRKTWTLCTAARNGNYLWSGRANQADILPDDIYSLGGIAVYLGYGAHRGQHFENDLLAVMRKCRDVCQRLFYGQTEGEATAAATATASAATPQPQTAPRPRMHVIAPRLERNRRRAQR
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: MEDH_BACMT
Sequence: MTNFFIPPASVIGRGAVKEVGTRLKQIGAKKALIVTDAFLHSTGLSEEVAKNIREAGLDVAIFPKAQPDPADTQVHEGVDVFKQENCDALVSIGGGSSHDTAKAIGLVAANGGRINDYQGVNSVEKPVVPVVAITTTAGTGSETTSLAVITDSARKVKMPVIDEKITPTVAIVDPELMVKKPAGLTIATGMDALSHAIEAYVAKGATPVTDAFAIQAMKLINEYLPKAVANGEDIEAREAMAYAQYMAGVAFNNGGLGLVHSISHQVGGVYKLQHGICNSVNMPHVCAFNLIAKTERFAHIAELLGENVSGLSTAAAAERAIVALERYNKNFGIPSGYAEMGVKEEDIELLAKNAFEDVCTQSNPRVATVQDIAQIIKNAL
What is the function of this protein?
Catalyzes the oxidation of methanol to yield formaldehyde.  It possesses a NADH-dependent formaldehyde reductase activity and cannot use NADP.
What are the official names of this protein?
NAD-dependent methanol dehydrogenase, MDH, MEDH, Type 3 alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SARA_STAAE
Sequence: MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
What is the function of this protein?
Global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner.  In a strain-dependent manner plays a role in multidrug resistance mechanism.  Is required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus.  Acts as a transcriptional activator of the genes encoding, among others, for fibronectin binding proteins (fnbA and fnbB), hemolysins (hla, hld, hlgB and hlgC), serine proteases (splA, splB, splD and splF) and of the bap gene, which is essential for biofilm development in some strains.  Negatively regulates the expression of the genes for protein A (spa), lipase (lip), thermonuclease (nuc), immunodominant staphylococcal antigen B (isaB), staphylococcal serine and cysteine proteases (sspA and sspB), staphostatin B (sspC), metalloprotease aureolysin (aur) and collagen adhesin (cna).  Probably activates the development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be sigma-B-dependent.
What are the official names of this protein?
Transcriptional regulator SarA, Staphylococcal accessory regulator A.
What is the protein family that this protein belongs to?
Belongs to the SarA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KEFF_ECO5E
Sequence: MILIIYAHPYPHHSHANKRMFEQARTLEGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVFSHGWAYGHGGTALHGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefC.  Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefF, Quinone oxidoreductase KefF.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRC_STRP6
Sequence: MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVVAFAQQLGAKVTAEVSPQHFSTTEDLLLTAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPFIGNKLKGVVKYTIADGEVVYPN
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: POL_JSRV
Sequence: MGHTHSRQLFVHMLSVMLKHRGITVSKTKLINFLSFIEEVCPWFPREGTVNLETWKKVGEQIRTHYTLHGPEKVPVETLSFWTLIRDCLDFDNDELKRLGNLLKQEEDPLHTPDSVPSYDPPPPPPPSLKMHPSDNDDSLSSTDEAELDEEAAKYHQEDWGFLAQEKGALTSKDELVECFKNLTIALQNAGIQLPSNNNTFPSAPPFPPAYTPTVMAGLDPPPGFPPPSKHMSPLQKALRQAQRLGEVVSDFSLAFPVFENNNQRYYESLPFKQLKELKIACSQYGPTAPFTIAMIESLGTQALPPNDWKQTARACLSGGDYLLWKSEFFEQCARIADVNRQQGIQTSYEMLIGEGPYQATDTQLNFLPGAYAQISNAARQAWKKLPSSSTKTEDLSKVRQGPDEPYQDFVARLLDTIGKIMSDEKAGMVLAKQLAFENANSACQAALRPYRKKGDLSDFIRICADIGPSYMQGIAMAAALQGKSIKEVLFQQQARNKKGLQKSGNSGCFVCGQPGHRAAVCPQKHQTSVNTPNLCPRCKKGKHWARDCRSKTDVQGNPLPPVSGNLGEGPAPGPETMLWGNTAGSKRTIADLCRATRGSAGLDLCATSYTVLTPEMGVQTLATGVFGPLPPGTVGLLLGRSSASLKGILIHPGVIDSDYTGEIKILASAPNKIIVINAGQRIAQLLLVPLVIQGKTINRDRQDKGFGSSDAYWVQNVTEARPELELRINANFFRGVLDTGADISVISDKYWPTTWPKQMAISTLQGIGQTTNPEQSSSLLTWKDKDGHTGQFKPYILPYLPVNLWGRDILSKMGVYLYSPSPTVTDLMLDQGLLPNQGLGKQHQGIILPLDLKPNQDRKGLGCFPLGTSDSPVTHADPIDWKSEEPVWVDQWPLTQEKLSAAQQLVQEQLRLGHIEPSTSAWNSPIFVIKKKSGKWRLLQDLRKVNETMMHMGALQPGLPTPSAIPDKSYIIVIDLKDCFYTIPLAPQDCKRFAFSLPSVNFKEPMQRYQWRVLPQGMTNSPTLCQKFVATAIAPVRQRFPQLYLVHYMDDILLAHTDEHLLYQAFSILKQHLSLNGLVIADEKIQTHFPYNYLGFSLYPRVYNTQLVKLQTDHLKTLNDFQKLLGDINWIRPYLKLPTYTLQPLFDILKGDSDPASPRTLSLEGRTALQSIEEAIRQQQITYCDYQRSWGLYILPTPRAPTGVLYQDKPLRWIYLSATPTKHLLPYYELVAKIIAKGRHEAIQYFGMEPPFICVPYALEQQDWLFQFSDNWSIAFANYPGQITHHYPSDKLLQFASSHAFIFPKIVRRQPIPEATLIFTDGSSNGTAALIINHQTYYAQTSFSSAQVVELFAVHQALLTVPTSFNLFTDSSYVVGALQMIETVPIIGTTSPEVLNLFTLIQQVLHCRQHPCFFGHIRAHSTLPGALVQGNHTADVLTKQVFFQSAIDAARKSHDLHHQNSHSLRLQFKISREAARQIVKSCSTCPQFFVLPQYGVNPRGLRPNHLWQTDVTHIPQFGRLKYVHVSIDTFSNFLMASLHTGESTRHCIQHLLFCFSTSGIPQTLKTDNGPGYTSRSFQRFCLSFQIHHKTGIPYNPQGQGIVERAHQRIKHQLLKQKKGNELYSPSPHNALNHALYVLNFLTLDTEGNSAAQRFWGERSSCKKPLVRWKDPLTNLWYGPDPVLIWGRGHVCVFPQDAEAPRWIPERLVRAAEELPDASDATHDPE
What is the function of this protein?
Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.
What are the official names of this protein?
Gag-Pro-Pol polyprotein.
What is the protein family that this protein belongs to?
Belongs to the retroviral Pol polyprotein family.
What are the subcellular locations of this protein?
[Matrix protein p10]: Virion. SUBCELLULAR LOCATION: [Capsid protein p27]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein-dUTPase]: Virion. SUBCELLULAR LOCATION: [Protease 13 kDa]: Virion. SUBCELLULAR LOCATION: [Protease 17 kDa]: Virion.
Protein: UPPP_SYNAS
Sequence: MKKHHLRHALLVLSAAILLAVSCSFSAASASASPPASEKKIAVWEAAILGVVEGITEYLPISSTGHLILASHALGMTQFSETRGPLGTLMVKNDAMDSYNIVIQLGAILAVLGLYRKRVKQMLKGLSGALAVLVSRRSVTALGDSERQGLKLLGLLLLAFLPAAVFGKLFHEVIETYLFGPLPVVYALVAGGVLMIGVEYFFWLKDRNRLRISDVNSMFYRQALFIGMMQVVSMWPGTSRSMITMIAGLIVGLDMIAAAEFSFLLALPTLGAATLYSGYKNWHALDDSAGMLALAVGLAVSWLTAVIAVKALVRWLTHHGLIPFGVYRILLAGVLLIYFWQWR
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR7_CHLAD
Sequence: MELGHVLSEGKTKIVYAHPTDPDLAILFHKDGITAGDGARRHVIAGKGALAGQTTANVFRFLNRAGIATHFIEAPEPKLTVVRRCVMIPLEVVMRRLPAGSYLRRYPEAAGQRFDPPLVEFFLKDDARHDPQITPDEIVAQGIATPAEVEQMTMTGQQVFTTLEAAWAKLDVTLVDLKIEFGRAGDGSLLVADVIDNDSWRIWPGGDPNRMLDKQVYRNAQVVDEDVLADVYARYAQVAELTGRWDAVTK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.