PharMolix/UniProtQA huggingface dataset:
Protein: LUCI_RENRE
Sequence: MTSKVYDPEQRKRMITGPQWWARCKQMNVLDSFINYYDSEKHAENAVIFLHGNAASSYLWRHVVPHIEPVARCIIPDLIGMGKSGKSGNGSYRLLDHYKYLTAWFELLNLPKKIIFVGHDWGACLAFHYSYEHQDKIKAIVHAESVVDVIESWDEWPDIEEDIALIKSEEGEKMVLENNFFVETMLPSKIMRKLEPEEFAAYLEPFKEKGEVRRPTLSWPREIPLVKGGKPDVVQIVRNYNAYLRASDDLPKMFIESDPGFFSNAIVEGAKKFPNTEFVKVKGLHFSQEDAPDEMGKYIKSFVERVLKNEQ
What is the function of this protein?
Upon binding the substrate, the enzyme catalyzes an oxygenation, producing a very short-lived hydroperoxide that cyclizes into a dioxetanone structure, which collapses, releasing a CO(2) molecule.  The spontaneous breakdown of the dioxetanone releases the energy (about 50 kcal/mole) that is necessary to generate the excited state of the coelenteramide product, which is the singlet form of the monoanion.  In vivo the product undergoes the process of nonradiative energy transfer to an accessory protein, a green fluorescent protein (GFP), which results in green bioluminescence.  In vitro, in the absence of GFP, the product emits blue light.
What are the official names of this protein?
Coelenterazine h 2-monooxygenase, Renilla-luciferin 2-monooxygenase, Renilla-type luciferase.
Protein: TRHO_HAHCH
Sequence: MSQYVICALYKFVALDNFEALRAPLLEVMEKNEVKGTLLLAREGVNGTVSGTREGMDALLAWLKSDPRLADLSYKESYDENIPFYRTKVKLKKEIVTMGVEGIDPKRVVGTYVKPQDWNALITDPEVLLIDTRNDYEVQIGKFKNAINPNTETFREFPDYVKSNLDPAKHKKVAMYCTGGIRCEKSTAYLKELGFEDVYHLEGGILKYLEDVPQEESTWEGECFVFDNRVAVDHSLNKGSYDQCHACRMPISAEDMQSEHYKKGVSCPHCYDKVSEDQLRRFAAREQQIELAKSRGEEHIGSEAAKAIKKRQAEKKLKRKNYHQHLTQGAE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RF1_ESCF3
Sequence: MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCNG1_HUMAN
Sequence: MIEVLTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSINFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPEMVP
What is the function of this protein?
May play a role in growth regulation.  Is associated with G2/M phase arrest in response to DNA damage.  May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
What are the official names of this protein?
Cyclin-G1, Cyclin-G.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin G subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=DNA replication foci after DNA damage.
Protein: ITR1A_CRYNH
Sequence: MSDEKNYGISLAAPARPDLGSRTASQLEKATASHVEFATPKDPGALHDATLMAGERTEKLTKFVVGLALFASVSGFCFGFDTGVISAALVSIKDDFGHILDDTEKEWISAATSCGALVGALSSGALADRVGRKWTLAVGDVWFTLGAIIICSSFSVVQMIVGRAVLGLGVGTAAAIAPLYIAEVAPTRFRGALVTVQSIAITGGQFFSYCIGIPLTGHNGWRIQFAIGIVPAVVQAAVVHFLPESPRYDLLRGQREAALATIHRSYKGMSEDYIAVKFAALEEVVGISADFNRGHTLGQKMRLVLTEGKYRKPAITALGIGIFQQLCGFNSLMYYAATIFSYAGFDNPTSVGLIVSGTNWFFTFVAMMILDRVGKRRILLSTYPGMIAGLALASVAFWKMTGSTGHRLVEGTEYPQQWSNMMLGMMVVFIAFYATGSGNITWTVGEMFPLEMRGIGASILAGGVWAANIVISATFLTLMNAIGPTPTFALYAGICLAGLIFIYFCYPEPSGLSLEEIQIIYNYGFGVQKSREIRAEHKLKAQEMRDRANSHIGGSATASDDQLNKV
What is the function of this protein?
Major transporter for myo-inositol (PubMed:20689743, PubMed:21398509).  Plays a role in the traversal of the host blood-brain barrier (PubMed:23592982).
What are the official names of this protein?
Myo-inositol transporter 1A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Protein: G6PI_BRUO2
Sequence: MARDAAKLEATVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHDGPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRKA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAT_SCHPO
Sequence: MTVQTAERTITLVQAIWPKLRKEAEKQCEVNPWLAKDLARKILSKKTLRESLSCVLALPLDHVTGSSESMENWFYSILGLNDEKIIRSAMIDLDRLYTTNPACPDLISAFLSFRGFHALQLYRIAHGLWSEGDKTSAVLVQNWTAVAYGVDIHPAASIGDGLFLDHALGIVIGETAIVEDGVSIWHNVTLGSTFKDSGARHPVIRKNAMLCTGATVLGRVEVGENAVVAAGALVTKDVAPNRLALGSPARDVGPVPQYFGALTNPNCTNK
What are the official names of this protein?
Putative serine acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RDH16_MOUSE
Sequence: MWLYLVALVGLWTLLRFFRVRQVVSHLQDKYVFITGCDSGFGTLLARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVTATQWVKEHVGNRGLWGLVNNAGISTPSGPNEWMKKQDFAHVLDVNLLGMIEVTLSMLPLVRKARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVAIIEPGFFLTGVTSSARLCSNTQMLWDQTSSEIREIYGEKYLASYLKRLNKLDKRCNKDLSGVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYLPTFLVDALLYWTSLKPEKAL
What is the function of this protein?
Oxidoreductase with a preference for NAD.  Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes.  Has higher activity towards CRBP-bound retinol than with free retinol.  Oxidizes 3-alpha-hydroxysteroids.  Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Retinol dehydrogenase 16, Cis-retinol androgen dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane.
Protein: RL11_RHOJR
Sequence: MPPKKKKLAGLIKLQIQAGQANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGNVVPVEISVYEDRTFDFKLKTPPAAKLLLKAAGVQKGSGEPHKTKVASVTMDQVREIAKTKQEDLNANDIEQAAKIIAGTARSMGITVDG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: FIMI_ECOLI
Sequence: MKRKRLFLLASLLPMFALAGNKWNTTLPGGNMQFQGVIIAETCRIEAGDKQMTVNMGQISSNRFHAVGEDSAPVPFVIHLRECSTVVSERVGVAFHGVADGKNPDVLSVGEGPGIATNIGVALFDDEGNLVPINRPPANWKRLYSGSTSLHFIAKYRATGRRVTGGIANAQAWFSLTYQ
What are the official names of this protein?
Fimbrin-like protein FimI.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: PIL2_SCHPO
Sequence: MGTQPSYSIHTLRAPPKAKQNQIPPSTTRRAVNVNKLGRQFRYPSVGMFTPEMAKRLAALVKMEKDLLRSYENVAMERKECANQLSYWGEDCDDDISDISDKLGVLLYEIGELEEHMVDRYDQYRVSLKTIRDIEASVQPTRVKKEKLLNSIYDVRSRDPESPKLITMEQELVREEAACLVAEAQLTNITRENFKRAFTLHIGTLLEHSEKVAILCGYAKKILDLLDDTPIVPGEPRPIYDGYNITRDYIVEAERELANWQNPFQTPEPLTDIDGLPSQSHYQTQFQASVVPRTDVINEPPRRYSHANGVTTSGTTHSYTSTGSKRYSQMGTEDYQPSFQPNILQSTQVVDNFEIGEEDDEEVGSQGVAETSMPSTSAQPIAA
What is the function of this protein?
Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway.  Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity).
What are the official names of this protein?
Probable sphingolipid long chain base-responsive protein pil2, Protein kinase inhibitor pil2.
Protein: MGSA_ECOLC
Sequence: MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: ISPDF_ALBFT
Sequence: MADTPALIPQSDTTPRCWALIPCAGTGSRAGATGPKQYQLLAGKPMVLHTLAAFAAVPRIARTLVVVAPDDAFFASQTLTDARFLVAACGGSTRAASVLNGLNFLLGQGAARHDWVLVHDAARCLIRPDQIDQLIDACWQDDVGGLLALPLPDTLKRESLGRVAATLERADKWLAQTPQMFRLGSLLDALQVAGTTVTDESSAMEAMGLSPKLVPGSAQNFKVTYPQDFCLAEAVLMTRSSGDSAPQQSASEFKRASDMNFRIGEGWDIHALVAGRKLLLGGVEIPYHLGLLGHSDADVLLHAITDALLGAAALGDIGTHFPDTDARFKGADSLVLLTEAARRVRAKGFEIGNVDSTVIAQAPKLMPYMAAMRAQIALALALEVDQVNVKAKTAEKMGPVGLGQAMEARATVLLRKFI
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: LIP5_ARATH
Sequence: MSNPNEPARALLPYLQRADELQKHEPLVAYYCRLYAMERGLKIPQSERTKTTNSILMSLINQLEKDKKSLTLSPDDNMHVEGFALSVFAKADKQDRAGRADLGTAKTFYAASIFFEILSQFGPVPPDIEQKHKYAAWKAADIRKAIKEGRKPTPGDPVDDDTDLSIPSSGPSGSYDHSASDTNTTSHHRTELDPPHDSNDDSSHHQFPEVPQHPLPPRFYDNPTNDYPADVPPPPPSSYPSNDHLPPPTGPSDSPYPHPYSHQPYHQDPPKHMPPPQNYSSHEPSPNSLPNFQSYPSFSESSLPSTSPHYPSHYQNPEPYYSSPHSAPAPSSTSFSSAPPPPPYSSNGRINIAPVLDPAPSSAQKYHYDSSYQPGPEKVAEALKAARFAVGALAFDEVSTAVEHLKKSLELLTNPSAGAGH
What is the function of this protein?
Involved in the endosomal multivesicular bodies (MVB) pathway.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).  Thought to be a cofactor of SKD1/VPS4, which catalyzes the disassembly of membrane-associated ESCRT-III (PubMed:17468262).  Target of pathogen-responsive mitogen-activated protein kinases (MPKs) that plays a critical role in plant basal resistance to Pseudomonas syringae in a SKD1-dependent manner by promoting multivesicular bodies (MVBs) trafficking upon plant infection (PubMed:25010425).
What are the official names of this protein?
Protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5, Protein EXTENSIN-LIKE, EXT-LIKE.
What is the protein family that this protein belongs to?
Belongs to the VTA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus. Endosome, multivesicular body. Note=Localized in multivesicular body when associated with SKD1.
Protein: MDAB_ECO57
Sequence: MSNILIINGAKKFAHSNGQLNDTLTEVADGTLRDLGHDVRIVRADSDYDVKAEVQNFLWADVVIWQMPGWWMGAPWTVKKYIDDVFTEGHGTLYASDGRTRKDPSKKYGSGGLVQGKKYMLSLTWNAPMEAFTEKDQFFHGVGVDGVYLPFHKANQFLGMEPLPTFIANDVIKMPDVPRYTEEYRKHLVEIFG
What is the function of this protein?
NADPH-specific quinone reductase.
What are the official names of this protein?
NADPH:quinone oxidoreductase MdaB, Modulator of drug activity B.
What is the protein family that this protein belongs to?
Belongs to the oxidoreductase MdaB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_MICLC
Sequence: MATSAKESAVAELTDLFRESSAAVLTEYRGLTVTELKQLRDSIRQDATYAVAKNTLAEIAAKDAGLEGLEAHLSGPTAIAFVTGDPVNVAKALRDFAKDHEKLVLKGGYMDGQPLDEAGIKKLADLESREVLLAKFAGAMKGSMSKAAALFQAPLSKTVRTVEALRAAQGEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y6095_PSEA7
Sequence: MSIRDWPEAERPREKLLEQGAATLSDAELLAIFLRTGVTGCSAVELARRLLGEFGSLRALLESDLAAFCGHLGLGVAKYAQLQAVLEMGRRHLAERLRRDSVLESPQAVRDYLKARLRHEQHEVFACLFLDTRHRVLAFEVLFQGSIDGASVYPRQVVKRALAHNAAALILTHNHPSGDARPSLADRQLTARLKEALALIDVRVLDHFIIGDGEPLSLAEYGWM
What are the official names of this protein?
UPF0758 protein PSPA7_6095.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: DXS_BURO0
Sequence: MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPNDRIVWDVGHQTYPHKILTGRRDQMHSLRQYDGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSQLNGDDRFSIAVIGDGAMTAGMAFEAMNNAGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEEFGFNYIGPIDGHDLDSLIPTLQNIRELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSTTPAKKTYTQVFGEWLCDEAERDTRVVGITPAMREGSGMVEFEKRFKDRYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFMRCIPNMTIMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVATVKEFTEIPLGKGEVRRRTSQPEGKRVAILAFGTMVAPSLAAAEELDATVANMRFVKPVDAALVRELAETHDYLVTVEEGCVMGGAGSACVEALMESGVIRPVLQLGLPDQFVDHGDHAKLLAQCGLDGAGIAKSIRERFLSPAADVAGHAKRVA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: DSBE_HAEIN
Sequence: MKKKLLVPLILFLSITIAFLVQLKRNAQGEDIKALESALVGKPVPAKNLTELFENKTYTNELFQQGEPVLLNVWATWCPTCYAEHQYLNKLAKEGVRIIGLDYKDESPKAMKWLKDLGNPYQVVLKDEKGSFGLDLGVYGAPETFIVDGKGVIHYRYAGDVNEKVWTQTLKPIYDKLSEQQ
What is the function of this protein?
Involved in disulfide bond formation.  Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme.  Possible subunit of a heme lyase (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein DsbE, Cytochrome c biogenesis protein CcmG.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: RL11_BACAA
Sequence: MAKKVIKMVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTADQAGLIIPVEITVFEDRSFTFITKTPPAAVLLKKVAGIESGSGEPNRNKVATVKRDKVREIAETKMPDLNAASVEAAMRMVEGTARSMGIVIED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RS19_MYCBP
Sequence: MPRSLKKGPFVDEHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHIKDDRKSKRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: ISPF_PHOPR
Sequence: MRIGHGFDVHKFGGEGPVIIGGVAIPYEQGLIAHSDGDVALHAVCDALLGAIGAGDIGRHFPDTDAEWKGADSRFLLRDVYSKVKDKGYRLGNLDVTIIAQAPKMAPYIDAMCQAIAEDLETDIGNVNVKATTSERLGFTGRKEGIACEAVVLINAQ
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: MRAZ_KLEP7
Sequence: MFRGATLVNLDSKGRLAVPTRYREGLIENAAGQLVCTIDIHHPCLLLYPLPEWEVIEQKLSRLSSMNPVERRVQRLLLGHASECQMDNAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQRVKEDIDAEQSATGELSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: HSP1_CAVPO
Sequence: MARYRCCRSPSRSRCRRRRRRFYRRRRRCHRRRRRCCRRRYTRRCKRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1, Cysteine-rich protamine.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SMP12_NAUMA
Sequence: ALAQLLSLAR
What are the official names of this protein?
Uncharacterized protein SMPP12.
Protein: QUEF_ANASK
Sequence: MPTQPSRDLQTFPNPKPGRPFEIAMECPEFTCVCPMTGQPDFATIRLRYVPAERCVELKSLKLYLWSFRNEGTFHEAVTNRICDDLVAALAPRWIEVVGDFAVRGGIHTVVTARHGERPAGV
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEDA_ECO5E
Sequence: MKKPLRQQNRQIISYVPRTEPAPPEHAIKMDSFRDVWMLRGKYVAFVLMGESFLRSPAFTVPESAQRWANQIRQEGEVTE
What is the function of this protein?
Activates the cell division inhibited by chromosomal DNA over-replication.
What are the official names of this protein?
Cell division activator CedA.
What is the protein family that this protein belongs to?
Belongs to the CedA family.
Protein: YJ133_YEAST
Sequence: MIAQSTRLAAAVSSSAASAGVSRIAASAMASTIFKRSPGNSFNSFKEYRENAKTYGPLSASLATRRHLAHAPKL
What are the official names of this protein?
Uncharacterized protein YJL133C-A.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: TT39C_MOUSE
Sequence: MAGSEEQWPRRREDGDPDAAAAPLQDAELALAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCESEEAGVIETIKNKIKKNVDARKSTPSMVDRLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKAWKIYSKCYVDINALQELYQKKLTEEPLASDAANDNHVVAEGVTEESLSRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLTYASESKDMKAPLATLALLWYHTVVRPFFALDGSDNKGGLDEAKAILLRKESAYPNSSLFMFFKGRIQRLECQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQLVFKEVQKLFKRKNNQIEQFSVKKAERFRKQTPTRALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKHLLLGAIHKCLGNSQDALQFFQRAARDELCRQSNSYVPPYACYELGCLLLDSAETVGRGRTLLLQAKEDFSGYDFENRLHVRIHAALASLRELVPQ
What are the official names of this protein?
Tetratricopeptide repeat protein 39C, TPR repeat protein 39C.
What is the protein family that this protein belongs to?
Belongs to the TTC39 family.
Protein: TRI38_MOUSE
Sequence: MGSDFSTVKIRKVTSCSICKAMMSHPVSINCGHSYCKSCIQSYYCNVSPKTGWKMLGCPLCSSPFSLENLRPNKELETIIDMIKGMEEQDQDMVCEEHEEKFNRFCEDDGQLLCWRCYWEDRHKGHTLAHVKDVYQNYKEKLQNTMTKLRELQENHEVQIHFITHQINAWKDAVEDRRQTIKSNFKNLQSFLQEEEKFYLWRLENEEKEMLVQLEGSEANLQQTFERAQCQIQELEAKCQGSAQKLLQDVKNTLSRCEAMKRNPLKADPLKVHTKCNVSELYFDVKTILRRHQVSVILDPSTAHLDLALTKGGRLVTYKRCPRDLQARSSAKRFYGLPCVLGCEGFTSGRYYFEVSVENATSWDLGVCVENVHRGFNMKKEPESGFWTIKMSEEDGLEALTSTPTPPLHLIEKPQILGVFLDYEAGAVSFYSVTTGSHIFTFPKASFQDTLRPFFQVYQYSPLFLPAINNQ
What is the function of this protein?
E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:22539786, PubMed:26392463, PubMed:27637147).  Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (PubMed:22539786).  Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:26392463).  Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (PubMed:27637147).  Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM38, E3 SUMO-protein ligase TRIM38, Tripartite motif-containing protein 38.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELU_PSEPK
Sequence: MRPDCTDFRQLFLDDVPMMDMRAPVEFAKGAFPGVVNLPLMNDQERQKVGTCYKQQGQAAAIALGHQLVSGATKQARLEAWAAFAKAHPDGYLYCFRGGLRSQIVQGWLRDEAGIQYPRVKGGYKAMRTFLLETTQQAVEQCDFVLVGGLTGTGKTDVLHQLDNVLDLEGHANHRGSSFGKRATAQPAQIDFENQLAIDVLKKRARGIGQFVLEDEGRIVGSCTVPLELYQGMQHYPLVWLEDSFTNRVERILRDYVVNLSAEFKAVHGEEDGPRLFAERMLQSMANIYKRLGGERHQRLSEMLREALQEQQRSGAVDLHRGWIEGLLNEYYDPMYAYQRAAKAERIEFAGDAVEVREYLKARALRQPRK
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.