PharMolix/UniProtQA huggingface dataset:
Protein: EFG_LACP3
Sequence: MANKREFPLDRTRNIGIMAHIDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMPQEQERGITITSAATTAFWKDHRVNIIDTPGHVDFTIEVERSLRVLDGAITVLDAQSGVEPQTENVWRQATTYGVPRLVFVNKMDKIGADFDYSMTTLHDRLQANAHAVQMPIGAEDKFEGVIDLIEMKADLYDEDELGTKWDTVDVPDDYKEAAQKAHNDLIEAVADVDDGIMDKYLEGEEISNAELKAAIRKATINLEFYPVLAGSAFKNKGVQMLLDAVIDYLPSPLDVRPYHATDPDTGDAVELTAGDDKPFAALAFKVATDPFVGRLTYIRVYSGTLEAGSYVLNATKDNRERVGRLLQMHSNHREEIPEVFSGDIAAAIGLKNTTTGDSLTDVDHPLILESLDVPDPVIQVSIEPDSKEDQDKLDVGLQKLSEEDPTFKAETSPETGETLIAGMGELHLDIMVDRLKREFKVAAKVGEPQVAYRETFTKETSAQGKFVRQSGGKGQYGDVWIEFSPNEEGKGFEFENAIVGGVVPREYIPAVEQGLKEAMANGVLAGYPLIDVKAKLYDGSYHEVDSSEAAFKVAASMALKNASKSAGAVILEPIMHVEVVAPEEYLGDVMGQITARRGRVEGMEARGNAQLVNSMVPLAEMFGYATTLRSATQGRGTFTMTFDHYEAVPKSIQAEIIKKNGGGVATKD
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SORCN_MOUSE
Sequence: MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV
What is the function of this protein?
Calcium-binding protein that modulates excitation-contraction coupling in the heart.  Contributes to calcium homeostasis in the heart sarcoplasmic reticulum.  Modulates the activity of RYR2 calcium channels.
What are the official names of this protein?
Sorcin.
What are the subcellular locations of this protein?
Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
Protein: DCD_CAMJD
Sequence: MGLKADNWIRKMALEHKMIEPFCEANIGKGVVSYGLSSYGYDICVGREFKIFTNVNSTVVDPKNFVEENVVDFEGDVCIVPANSFALARTIEYFKMPDDVLAICLGKSTYARCGIIVNVTPFEPGFEGHITIEISNTTPLPAKIYANEGIAQVLFLQGDEKCDTTYKDKKGKYQAQTGITLPRILK
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: ACER1_HUMAN
Sequence: MPSIFAYQSSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIYVVWVLFMIIGLFSMYFHMTLSFLGQLLDEIAILWLLGSGYSIWMPRCYFPSFLGGNRSQFIRLVFITTVVSTLLSFLRPTVNAYALNSIALHILYIVCQEYRKTSNKELRHLIEVSVVLWAVALTSWISDRLLCSFWQRIHFFYLHSIWHVLISITFPYGMVTMALVDANYEMPGETLKVRYWPRDSWPVGLPYVEIRGDDKDC
What is the function of this protein?
Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:17713573, PubMed:20207939, PubMed:20628055).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875).  Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:17713573, PubMed:20207939).  May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055).  ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573).
What are the official names of this protein?
Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3.
What is the protein family that this protein belongs to?
Belongs to the alkaline ceramidase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SMD1A_ARATH
Sequence: MKLVRFLMKLNNETVSIELKNGTVVHGTITGVDVSMNTHLKTVKMSLKGKNPVTLDHLSLRGNNIRYYILPDSLNLETLLVEDTPRVKPKKPVAGKAVGRGRGRGRGRGRGRGR
What is the function of this protein?
Involved in splicing regulation.  Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS.  Does not participate in the production of small RNAs.
What are the official names of this protein?
Small nuclear ribonucleoprotein SmD1a, AtSmD1-a.
What is the protein family that this protein belongs to?
Belongs to the snRNP core protein family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Nucleus, nucleolus.
Protein: PEPT_ECOLC
Sequence: MDKLLERFLNYVSLDTQSKAGVRQVPSTEGQWKLLHLLKEQLEEMGLINVTLSEKGTLMATLPANVPGDIPAIGFISHVDTSPDCSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGIAEIMTALAVLQQKNIPHGDIRVAFTPDEEVGKGAKHFDVDAFDARWAYTVDGGGVGELEFENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADESPEMTEGYEGFYHLASMKGTVDRADMHYIIRDFDRKQFEARKRKMMEIAKKVGKGLHPDCYIELVIEDSYYNMREKVVEHPHILDIAQQAMRDCDIEPELKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAELTAQRK
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLF1_PONAB
Sequence: MFRMLSSSFEDDPFFSESILAHRENMRQMMRSFTEPFGRDLLSISDGRGRVHNRRGHNDGEDSLTHTDVSSLQTVDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRHNLENTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSDVLGDKLHIKGSSVKSNKK
What is the function of this protein?
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation.  Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels.  Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.  Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus (By similarity).
What are the official names of this protein?
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1.
What is the protein family that this protein belongs to?
Belongs to the MLF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Shuttles between the cytoplasm and nucleus.
Protein: MPIP3_XENLA
Sequence: MIKERVTPPFQASGGSGVVMAESHIISSEAPPKSNPGLNIRTNCRMILNLLREKDCSVTFSPEQPLTPVTDLAVGFSNLSTFSGETPKRCLDLSNLGDETAPLPTESPDRMSSGKLESPKTQFVQFDGLFTPDLAWKAKKCPKRNMNSVLPHLLCSTPSFKKASGGQRSLSNKENEGELFKNPNCKPVALLLPQEVVDSQLSPTPENKVDISLDEDCEMNILGSPISADPPCLDGAHDDIKMQNLDGFADFFSVDEEEMENPPGAVGNLSCSMAILLSGPLLNQDVEISNVNNISLNRSRLYRSPSMPEKLDRPMLKRPVRPLNSETPVRVKRRRSTSSPLQPEEENCQPQRRGTSLKKTLSLCDVDISSVLDEDCGHRQLIGDFSKVYALPTVTGRHQDLRYITGETLAALMHGDFNSLVEKFFIIDCRYPYEYDGGHIKSAFNLHRQDEVTDYFLQQPLTPLMAQKRLIIIFHCEFSSERGPKMCRSLREEDRASNDYPSLYYPELYLLKGGYKDFFPEYKELCEPQSYCPMHHQDFREDLLKFRTKCKTSVGDRKRREPEFRLTGQRLG
What is the function of this protein?
This protein functions as a dosage-dependent inducer in mitotic control.  It is a tyrosine protein phosphatase required for progression of the cell cycle.  It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.
What are the official names of this protein?
M-phase inducer phosphatase 3.
What is the protein family that this protein belongs to?
Belongs to the MPI phosphatase family.
Protein: HAUS7_HUMAN
Sequence: MAGQDAGCGRGGDDYSEDEGDSSVSRAAVEVFGKLKDLNCPFLEGLYITEPKTIQELLCSPSEYRLEILEWMCTRVWPSLQDRFSSLKGVPTEVKIQEMTKLGHELMLCAPDDQELLKGCACAQKQLHFMDQLLDTIRSLTIGCSSCSSLMEHFEDTREKNEALLGELFSSPHLQMLLNPECDPWPLDMQPLLNKQSDDWQWASASAKSEEEEKLAELARQLQESAAKLHALRTEYFAQHEQGAAAGAADISTLDQKLRLVTSDFHQLILAFLQVYDDELGECCQRPGPDLHPCGPIIQATHQNLTSYSQLLQVVMAVADTSAKAVETVKKQQGEQICWGGSSSVMSLATKMNELMEK
What is the function of this protein?
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
What are the official names of this protein?
HAUS augmin-like complex subunit 7, 26S proteasome-associated UCH37-interacting protein 1, UCHL5-interacting protein, X-linked protein STS1769.
What is the protein family that this protein belongs to?
Belongs to the HAUS7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Protein: RYBPB_DANRE
Sequence: MGDKKSPTRPKRQAKPTADNGFWDCSVCTFRNSAEAFKCSICDVRKGTSTRKPRINSQLVAQQVAQQYATPPPPKKEKKEKPERPEKDRAEEERPDINPPDEHPVEQRDKDKSEKEQPEKEKKDREKEIIPAITKKPNSKKNRPKSDIHQSPPSERNSIQSGKSTTKTKNSHNSRPKLKNIDRSTAQQLAITVGNVTVIITDFKEKTRTSSTSSSTVTSSASSEQQHQSSGSESMDKGSSRASTPKGDLSLGHDESF
What is the function of this protein?
May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1.
What are the official names of this protein?
RING1 and YY1-binding protein B, Death effector domain-associated factor B, DED-associated factor B.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Primarily found in the nucleus.
Protein: FADJ_PECAS
Sequence: MNDQQPFSVTASPTTEKTSAFSLTIRPDNIGVISIDVPGERVNTLKSEFAEQILSVFELARQHATLRGLIFISAKPDSFIAGADITMLNKCSSAEQAENLAKQGQETFDQIAALPFPVVAAIHGACLGGGLELALACDYRVCSLDEKTVLGLPEVQLGLLPGSGGTQRLPRLIGLDSALDLILTGRHLRAGQALRQGLVDEAVPHDILLDTAVEILKKGKRKAVPLGWRSRLLNSPGIRHLLFKMVKRKTRAKTHGNYPATEKIIQVVRRGIEKGREEGYRHEARAFGKLVMTPESAALRHLFFATNALKKTSGAASEAKPIHRVGILGGGLMGGGIASVTATRGQLPVRIKDINEQGINHALKYNWQLLTKRVQSKRMKPTERQRLMTLISGSTDYRGFEHADIVIEAVFEDLALKRQMITEIEDHAAPHTIFASNTSSLPIHQIAEGARRPQLVVGLHYFSPVDKMPLVEVIPHAHTSAETVATTVALARKQGKTAIVVGDSAGFYVNRILAPYINEAAYCLLEGEPIESIDYALVRFGFPVGPLALLDEVGIDVATKIVPVLSEELGDRFTSPPAFDAILKDGRKGRKNGKGFYRYNKTRRFWHSGKEVDSSVYPLLDVTPKAHIDPALISQRAVMMMLNEAARCLDEGVIQCARDGDIGAVFGIGFPPFLGGPFHYMDRLGMETVVKTLLVLQQQYGDRFAPCERLLTMREGQRTFYPPADKDNSIS
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDHC_NAEFO
Sequence: AXFQKIKVANPVVELDGDEM
What are the official names of this protein?
Isocitrate dehydrogenase [NADP], IDH, IDP, NADP(+)-specific ICDH, NF033, Oxalosuccinate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK16_PHAAO
Sequence: MLSPKRTRFRKQHRGRMKGISCRGNHICFGRYALQALEPAWITARQIEAGRRAMTRYARRGGKIWVRIFPDKPVTVRPTETRMGSGKGSPEYWVSVVKPGRIIYEMSGVSEAVAKAAMEIAACKMPIRTQFVISG
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HTPX_SHEDO
Sequence: MKRVFLLIATNLAILLVASIVMSILGVNTSTMGGLLVFAAIFGFGGSFISLAISKWMAKKTMGCEVIVQPRDETERWLVDTVTRQAKQAGINMPEVAIYQSPEMNAFATGPSKNNALVAVSTGLLYGMTRDEIEGVLAHEVSHVANGDMVTLTLIQGVVNTFVIFAARVVAGIIDNFVSSNDEEGQGLGMFAYMGVVFVLDMLFGILASIIVAYFSRIREFKADEGAARLAGKDKMIAALERLRAGPESGAMPAQMSAFGINGKRSMADFMMSHPPLEKRIAALKNS
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTA_ECOLI
Sequence: MSRIIMLIPTGTSVGLTSVSLGVIRAMERKGVRLSVFKPIAQPRTGGDAPDQTTTIVRANSSTTTAAEPLKMSYVEGLLSSNQKDVLMEEIVANYHANTKDAEVVLVEGLVPTRKHQFAQSLNYEIAKTLNAEIVFVMSQGTDTPEQLKERIELTRNSFGGAKNTNITGVIVNKLNAPVDEQGRTRPDLSEIFDDSSKAKVNNVDPAKLQESSPLPVLGAVPWSFDLIATRAIDMARHLNATIINEGDINTRRVKSVTFCARSIPHMLEHFRAGSLLVTSADRPDVLVAACLAAMNGVEIGALLLTGGYEMDARISKLCERAFATGLPVFMVNTNTWQTSLSLQSFNLEVPVDDHERIEKVQEYVANYINADWIESLTATSERSRRLSPPAFRYQLTELARKAGKRIVLPEGDEPRTVKAAAICAERGIATCVLLGNPAEINRVAASQGVELGAGIEIVDPEVVRESYVGRLVELRKNKGMTETVAREQLEDNVVLGTLMLEQDEVDGLVSGAVHTTANTIRPPLQLIKTAPGSSLVSSVFFMLLPEQVYVYGDCAINPDPTAEQLAEIAIQSADSAAAFGIEPRVAMLSYSTGTSGAGSDVEKVREATRLAQEKRPDLMIDGPLQYDAAVMADVAKSKAPNSPVAGRATVFIFPDLNTGNTTYKAVQRSADLISIGPMLQGMRKPVNDLSRGALVDDIVYTIALTAIQSAQQQ
What is the function of this protein?
Involved in acetate metabolism (PubMed:16080684).  Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate (PubMed:16080684).  The direction of the overall reaction changes depending on growth conditions (PubMed:16080684).  On minimal medium acetyl-CoA is generated.  In rich medium acetyl-CoA is converted to acetate and allowing the cell to dump the excess of acetylation potential in exchange for energy in the form of ATP (PubMed:15687190).  The main pathway for acetate production during exponential phase (PubMed:16080684).
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN135_MOUSE
Sequence: MAAVCSGNAVPVWLSEDDLSCIICQGLLDQPTTLPCGHSFCLRCLHDLWVSKRGAVDGCPWACPICRKGPLTKPKLHKNPLLQDLVDKYLQAAREVEAGSEPEPAPAPRSAPQVTVQKSTTNVIQELTDMVRQLVDDVKSLQTQRPNLGSGQDNAQGTPPTDSSSEGEHSLDSPKLVTFSISQKKIQEILHNLEEIQEKLQGSVPGRAPPRERVQEMTSSLCLLPDQRRPAPRKASHLSLWAISPTFDLRTLSYNLEVSNNSRRVTVSRGDLHTYHWSPQRFSISQVFCSQALSSGQKYWEVDTRNCSHWAIGVASWGMKRDGMLGRTMDSWCIEWRGPGQFSAWAKMKKTDLQSDLPEVVGVWLDLESGELAFYAVADHERLLYECEVSSSSPLHPAFWLYGLSPGNYLEIKQLNT
What is the function of this protein?
E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531).  Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:21147464, PubMed:28469175, PubMed:31006531).  Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531).  This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (PubMed:31006531).  Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (By similarity).  It is not involved in the innate immune response against DNA viruses (PubMed:21147464).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF135, RING finger protein 135, RING-type E3 ubiquitin transferase RNF135.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, Stress granule.
Protein: BIPD_BURM7
Sequence: MNMHVDMGRALTVRDWPALEALAKTMPADAGARAMTDDDLRAAGVDRRVPEQKLGAAIDEFASLRLPDRIDGRFVDGRRANLTVFDDARVAVRGHARAQRNLLERLETELLGGTLDTAGDEGGIQPDPILQGLVDVIGQGKSDIDAYATIVEGLTKYFQSVADVMSKLQDYISAKDDKNMKIDGGKIKALIQQVIDHLPTMQLPKGADIARWRKELGDAVSISDSGVVTINPDKLIKMRDSLPPDGTVWDTARYQAWNTAFSGQKDNIQNDVQTLVEKYSHQNSNFDNLVKVLSGAISTLTDTAKSYLQI
What is the function of this protein?
Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation.  Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane (By similarity).
What are the official names of this protein?
Translocator protein BipD.
What is the protein family that this protein belongs to?
Belongs to the invasin protein D family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the bsa type III secretion system. Localizes to the tip of the external secretion needle that is part of the secretion apparatus (By similarity).
Protein: T23O_DROGR
Sequence: MSCPYAGNSNEHDDAAVPLSNDVGKIYGEYLMLDKLLDAQCMLSMEDKRPVHDEHLFIITHQAYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVKYNQKYSDVFGNDERALNAIRSSEDNPSLLELVQRWLERTPGLEADGFNFWEKFQHSVDQFLAAQVHSALLEPVEQAKNYRLMDIEKRREVYRSIFDPALHEALVKRGDRRFSHGALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDESIRQKLIH
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Protein vermilion, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: TSC10_KLULA
Sequence: MKGFNCNGQVILISGGSQGLGESFAKRFVQDDDGPGSNTNKVIIVSRSQSKLVKACERIGVDGVSLDRYVNDTNRNETKLIYHSCDTSSYDKVALMFKLLVKSELVPSQVYMCAGGSIPKLFLDLTPEELQNGITTNYSTAVNLAHVSLKHDVPHLLFFSSEVAFFPFIGYAQYAPLKQSIRSLVAILRQEHSSTRITCVYPGNFQSEGFDLENITKPAITKEIEGPSNPVTAAQCRDKIISSLKWGLDDITTDSIGWLLMACDQGLNKHSTSQFMFVFSWILGALLNITIVPIYMLICKFQIYQWKRNKDTK
What is the function of this protein?
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
What are the official names of this protein?
3-ketodihydrosphingosine reductase TSC10, 3-dehydrosphinganine reductase, KDS reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: Y1245_METJA
Sequence: MTKRVLFELFVEEKNVGKAINIMTLAGITGFFLHKYRGLSPDKFKNLSKEELEDIEKVYEIIRDESDKAVVIGTVVKEEKAKKIEELLKEKMNNERWTVMKIPILKVKVHRV
What are the official names of this protein?
Uncharacterized protein MJ1245.
What is the protein family that this protein belongs to?
To M.jannaschii MJ1244 and M.thermoautotrophicum MTH1110.
Protein: RSMG_PROMM
Sequence: MSNQACFSNPGPELWNALGWHPSSEQLEQMIALQALLRQWNARVNLTRLVEGGDYWIMQVFDSLWPLQSELQNAQQPRRCIDIGSGGGFPGLVLAIALPGARITLVDSVGRKTAALKAMAAKLGLTSRVTVRSERAEFTGQDPCCRGLFDLAMARAVSTAPVVAEYLVPLLKPSGEALLFRGHWSPNDAKDLAKALRLLQADLIKMERRELPDNRGVRHQLRLRATLPCPATFPRPIGVPAKNPLGS
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGRB_SHIFL
Sequence: MKKFRWVVLVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINQFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MTRF_METTM
Sequence: MIILSNKPNIRGIKNVVEDIKYRNQLIGRDGRLFAGLIATRISGIAIGFLLAVLLVGVPAMMSILGVI
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit F, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit F.
What is the protein family that this protein belongs to?
Belongs to the MtrF family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DEF2A_SINAL
Sequence: QKLCQRPSGTWSGVCGNNNACRNQCINLEKARHGSCNYVFPAHKCICYFPC
What is the function of this protein?
Possesses antifungal activity sensitive to inorganic cations.
What are the official names of this protein?
Defensin-like protein 2A, Cysteine-rich antifungal protein 2A, AFP2A, M2A.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
Protein: CYB_ZANCU
Sequence: MKLLKSNPVLTLFNDYIVDSPAPSNISYLWNFGSLLGICFIIQIITGVFLAMHYTPNIDLAFLSIEHIMRDVNNGYIIRYMHANGAGFFFICVYIHIAKGIYYGSYRKPRVFLWTIGVIIFFLMIIIGFLGYVLPFGQMSLWGATVITNLCSAIPWIGTDLVNFIWGNYSVSNATINRFFSLHYLLPFVLAALVILHLIGLHQNGSNNPLGISSNVDKIPFHPYFSYKDYVGFFSFFLIFFYFVFFTPNLLVEPDNYIPGNPLVTPTAIVPEFYLLPFYTILRSIPNKLLGVIGMVAAILIFLILPFVDISNVRSTQFKPLFKLFFYIFVVNFLILGWIGANHAELPFTIIGQYSSIFYFSYFLFIIPLLGIIENTFSSIITKNNTPLFYFLNHKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LPXD_VIBVY
Sequence: MMTLTLAELAKITGGELHGDETVCVSRVAPMDKAGEGDVTFLSNPKYAVHLAECKATVVMLKAEQRKHCSGHVLVVDDPYVAFAKVAQALDTTPKPADGIAPSAVIASDAILGQNVSIGANAVIETGVSLGDNVVIGAGCFIGKNATIGQNTKLWANVTIYHQVQIGADCLIQAGTVIGSDGFGYANDRGEWIKIPQLGSVRIGNRVEIGACTTIDRGALDDTIIEDNVVLDNQLQIAHNVHIGYGTVMPGGTIVAGSTTIGKYCAIGGASVINGHITIADGVNITGMGMVMRSIEEKGVYSSGIPLQTNKQWRKTAARVHRIEEMNKRLKAVEKIVEQKKED
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.