PharMolix/UniProtQA huggingface dataset:
Protein: PUB40_ARATH
Sequence: MEIQRPVINLMVLHSQHDKSDNLSRRESLAGKSKWRTSLSRSSSSSSSNNNSPTKTEIPAEFLCPISGSLMADPIIVSSGHSYERACVIACKTLGFTPTPPPDFSTVIPNLALKSAIHSWCERRCFPPPKPLNSAAAEKLILALMEKKPQRRKVSVSEKELIQAIRDKPSVRLNHAATELDRRPNYFNSSSDESIASSSRTLQLTTKPSCFSSPSSGEIESLEPNLTPEEEALLTKLKSNRISEIEEALISIRRITRIDESSRISLCTTRVISALKSLIVSRYATVQVNVTAVLVNLSLEKSNKVKIVRSGIVPPLIDVLKCGSVEAQEHSAGVIFSLALEDENKTAIGVLGGLEPLLHLIRVGTELTRHDSALALYHLSLVQSNRGKLVKLGAVQMLLGMVSLGQMIGRVLLILCNMASCPVSRPALLDSGGVECMVGVLRRDREVNESTRESCVAVLYGLSHDGGLRFKGLAMAANAVEELVKVERSGRERAKQKARRVLEVLRAKIEDDDLVENEEIDWEELLNSGDVSRSRCRLGGEKSCVNSAEF
What is the function of this protein?
Functions as an E3 ubiquitin ligase.
What are the official names of this protein?
U-box domain-containing protein 40, Plant U-box protein 40, RING-type E3 ubiquitin transferase PUB40.
Protein: ALBA1_AERPE
Sequence: MSIEPQKPNTILVGRKPTINYVMAALKLLNEEGAPEVVIKARGRNICNAVDTVEMLKNLFIKNLVIKKVNIYSESLDSEGKKKVSAIEIVVAKG
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).
What are the official names of this protein?
DNA/RNA-binding protein Alba 1.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: DAPF_CUPNH
Sequence: MKLQFTKMHGAGNDFVVLDGIHQQIDLTPAQWRALASRHFGVGADQILIVEKPSRPDVDFRYRIVNADGSEVEHCGNGARCFVRFVTDKGMTDKRSVRVEVMNGVITLTLQDDGQVTVDMGAPELEPARVPFRAEGLPTRAEGADTLYGLEVNGRTEWISVVSMGNPHAVQVVDDVENFPVLQDGPVVEHHAAFPNRVNAGFMQVQDRHAIRLRVYERGAGETLACGTGACAAVVAGIRRGLLDSPVRVHTHGGDLTIAWDGGAEPVRMTGPATTVFEGSIDLAALPA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DABA_HYDS0
Sequence: MVKAYLDNVRKYIPHYWPMTTFVHHNPLHGFEDMPFKEALKQASKLYKAKVYMDPDYYVELYKEGIIKRDILEKNLFEFLKSIGLQMYFAESKKFITEISQDWKYYKVKSSTTPDINLIDYFNQKIVKDEDTLFQELIEDMMLSEILDAILEDNTTDIIEKEILEFVARFLDEGQTTMSMPEREKGMFGAFKLYEGLNTSLNEEEYADTILHELSPKNVERYILNHLLKDFGWAAFIKYREDNEDYYFQQIHPASLLEYLAVRLHYEKKYLNHYPISNFVELQKAFEQNKTLFVLKLLKAKNILPSKYIDRLEEKDSPKAILSDYLSEEVFLEAYRIQNIANELLLHLDKQKDITDFAFLIEKLKEEEGYIWLKSLEDSYIKEYTIDFLQSNEKIQRDILASAVFCIDVRSEAIRRHIERLGNYNTYGVAGFFGTPIAFIEFDKGHEQYLCPALIKPQKIIFELPEDEHHDYKTKHNINYTFKKTLESLKNNPYTPFFMVEAMGWLFGVNLFGKTLFPDFTLKILSFIKAKKPKTRFTIDKLSQEEIEFYAQKFFIQKIQEAYHQEFKKHINDKKAKDLFEAIINENHKGIDERILEILKTKYNINKESFELEKIRLSNVGYTEEEQIKLVENFLKLIGLTENIPKFVLLIAHGSTSDNNPFESALDCGACGGNNGLPNVRILASIANRNQIRKGLEKVGIKIPEDTIFIPGIHNTTTDEITFYDTEVMPQKDRALFDKIVKDFKIASQKTREERAKTLPYAGSGDRIPVRAIDWSETRPEWGLSKNMGVYVGKRSSTQNIALKNRFFMQSYTWEIDKDNKILKNILSGPFIIGEWINMEHYFSTTDNERLGAGSKVYHNVVAKVGVWTGNYGDLRTGLPYQTVYHDGVPYHEPIRLLTFIEAPAEKVLEAAQEVKEALKLVVNEWVRLIIIDKLKGVAYTFKDGNLEVLVDSRGINQFVI
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SSUD_ECOK1
Sequence: MSLNMFWFLPTHGDGHYLGTEEGSRPVDHGYLQQIAQAADRLGYTGVLIPTGRSCEDAWLVAASMIPVTQRLKFLVALRPSVTSPTVAARQAATLDRLSNGRALFNLVTGSDPQELAGDGVFLDHSERYEASAEFTQVWRRLLLGETVDFNGKHIHVRGAKLLFPPIQQPYPPLYFGGSSDVAQELAAEQVDLYLTWGEPPELVKEKIEHVRAKAAAHGRKIRFGVRLHVIVRETNDEAWQAAERLISRLDDETIAKAQAAFARTDSVGQQRMAALHNGKRDNLEISPNLWAGVGLVRGGAGTALVGDGPTVAARINEYAALGIDSFVLSGYPHLEEAYRVGELLFPHLDVAIPEIPQPQPLNPQGEAVANDFIPRNVAQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: SNTB1_MOUSE
Sequence: MAVAAAAVAAPAGGGGARAQRSGLLEVLVRDRWHKVLVNLSEDALVLSCEEGAAAYNGIGAATNGSFCRGSGTGHPVPGVAQAPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGGSAEPLSSQSFSFHRDRKSIPLKMCYVTRNMTLADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNAGDLLTRVVADIREQLGKTGIAGSREIRHLGWLAEKVPGESEKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHSYPLLATRLVHSGPGKGSPQAGMDLSFATRTGTKQGIETHLFRAEISRDLSHWTRSIVQGCHNSAELTAEITTACTYRNQECRLTIHYDNGFSISTEPQDGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKEGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA
What is the function of this protein?
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins.  May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
What are the official names of this protein?
Beta-1-syntrophin, 59 kDa dystrophin-associated protein A1 basic component 1, DAPA1B, Syntrophin-2.
What is the protein family that this protein belongs to?
Belongs to the syntrophin family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
Protein: RBM4_MOUSE
Sequence: MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVRTPYTMSYGDSLYYNNTYGALDAYYKRCRAARSYEAVAAAAASAYSNYAEQTLSQLPQVQNTAMASHLTSTSLDPYNRHLLPPSGAAAAAAAAAACTAASTSYYGRDRSPLRRATGPVLTVGEGYGYGHDSELSQASAAARNSLYDMARYEREQYADRARYSAF
What is the function of this protein?
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation.  Modulates alternative 5'-splice site and exon selection.  Acts as a muscle cell differentiation-promoting factor.  Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation.  Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin.  Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs.  Required for the translational activation of PER1 mRNA in response to circadian clock.  Binds directly to the 3'-UTR of the PER1 mRNA.  Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation.  Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress.  Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions.  Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs.  Associates with miRNAs during muscle cell differentiation.  Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
What are the official names of this protein?
RNA-binding protein 4, Lark homolog, mLark, RNA-binding motif protein 4, RNA-binding motif protein 4a.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation (By similarity).
Protein: YCHF_MYCPN
Sequence: MLSAGIVGLPNVGKSTLFSAITNLQVEIANYPFATIEPNAGIVNVIDERLDKLASLIKPDKVTHTTFRFVDIAGLVKGASKGEGLGNQFLANIREVDLICHVVRCYEDKKIVHVNNQVDPVFDFEIIVNELIQADIEVVNTRIGKIKRKAESGDKQSKEEYQLLAPVLQGLQQNQMVLHLVNEVDLKKLKSLNLLTAKPILVVANVSEADLSNLDHNPHLTQLNQFLKQHNLPHAIPVCALLENELSSLDANGRQDWLKELGLSDYQGLNQLIKTAYDAIGLWSFFTFGKQEVRAWAFKKGWLAPQCAGEIHTDFERGFIKVEVISWNQLYELKSLQEAKKQGLVRLRGQGLRDARWWCVSL
What is the function of this protein?
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
What are the official names of this protein?
Ribosome-binding ATPase YchF.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
Protein: ATPE_LEGPC
Sequence: MSITTHLDIVSAEHEIFSGVVEMVVATGELGEIGITPGHAPLLTVLRPGEVRITLQGGTQDIYYVQGGMLEVQPHCVTILADVAERAEHLDEAAALAAKAKAEAAIASKGGDIDYSVAAAELARAVAQIRAIQKTRKKMK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MATK_ACMAM
Sequence: MEEYQLYLELDRYRQQDFLYPLVFHEYIYGLAYSHDLNRSIFVENIGYDKKYSLLIVKRLITRMYRQNHLIISAKDSNKNRFLRYNKNFYSQIISEGFAIVVEILFSLQLSGSLEEAEIIKSYKNLRSIHSIFPFFEDKVTYLNYISDIRVPYPINLEILVQILRYWVKDAPLFHLLRLFLYDYCNWNSIIIPKKSIFLFSKNNPRFFFFLYNFYLCEFESIFFFLRTKSSHLRLKSFRVFFERIFFYAKKGHLVEVFLKDFFSTLTFFKDPFIHYVRYQGKSILASKNLPILMNKWKYFFIHLWQCYFDVWSQPRTIHINQLSEYSFHFLGYFLKVGLKHSVVRGQMLQNGFLIKILIKKLDIIVPIIPIIRLLAKSKFCNVLGNPLSKPSWADLSDFEIIARFLRICRNLSHYYNGSSKKKSLYRIKYILRLSCIKTLACKHKSSVRAFLKRLGSEELLEEFFTEEEEILSLIFPRTSSTLRRLHRNRIWYLDILFSNDNDIINHD
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MLTF_SALPA
Sequence: MKKLKINYLFIGILTLLLAAALWPSIPWFGKTENHIAAIQARGVLRVSTIDSPLTYSVINGKKYGLDYELAQQFANYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYDSARVKNYQPGPMYYSVSQQLVYRVGQYRPRSLATVNENQLTIAPGHVVVNDLQRLKETKFPDLSWKVDDKKGSTTLLEEVISGKLDYTIADSVAIGLFQRVHPELAVALDVTDEQPVTWFSRLDDNNTLSAALLDFFNSINEDGSLARIEEKYLGHGDDFDYVDTRSFLRAVDNVLPELEPLFKKYAKEIDWRLLAAISYQESHWDPLATSPTGVRGLMMLTKNTAQSLGLTDRTDAEQSISGGARYLEDMMAKVPETVPEDERIWFALAAYNMGYAHMLDARSLTVKTKGNPDSWTDVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQEAEAMKLAQDYPAVSPEELNKAPFPLLSFLSQSSGYLTHSPSLLFTPQKKEEK
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: RL10_LISW6
Sequence: MSKVLEAKQSAVEEIKTKLSASASTVIVDYRGLNVGEITELRKQLRDAGIEFKVYKNSLTRRAVEANGYEGLEGALTGPNAIAFSNEDVVAPAKILNDFAKDHEALEIKAGVIEGKVASLEEIKALATLPSREGLLSMLCNVLQAPVRGLAIATKAVADQKEGQEA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: GGR_PYRHO
Sequence: MRYDVVVVGSGVAGPIVARNVAKAGFSVLLVDKKPAIGAPKQCAEGLTINAFKQFDIPYDKRFINREIYGAKIYSPSGYTAELRYKEVSGVILERKVFDKMLAYYAAKAGAEVLARTEVVDVIRREGKIVGVKAKHEGEPMEIEAKVIVAADGVESTIARKAGIDTYAPPHEFDSGYEYEMIIEGFDPDLIHLFFGNEVAPRGYVWVFPKDEDRANVGIGINSDNEKTAKYYLDKWLKENNIPRNKILEVNVGLIPVGGFVKELVKENVLVVGDAARQVNPIHGGGMAEAMKASTIASKWIIKALEEENLELLKNYKEEWWKTEGPRMEKLLRLRRAMEKLTDEDLDVFVQLVSGTDLEKIAGGNYIEVVKALMKHPKVLMSRRRLEILKALL
What is the function of this protein?
Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids.  Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
What are the official names of this protein?
Digeranylgeranylglycerophospholipid reductase, DGGGPL reductase, 2,3-bis-O-geranylgeranylglyceryl phosphate reductase, Geranylgeranyl reductase, GGR.
What is the protein family that this protein belongs to?
Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
Protein: Y146_NPVOP
Sequence: MNVYLYQPDGEQDNDVTFYMPHATNGVIVYLFKMGAEAAPDRTRLVSGYEAGRPIGLRLAVGACNDAFVLSCVRAPCVFRELFIHNRYTAPLGLAVVRAGRAAPEAWHVLSVHRRSEAKRTRHIRALRVHSNVGPDQCYPKALISLAGNVPASFLNTLQRCRAHHKDVAAMAMLCPDLRVDDSVVQFDGVQASIKLR
What are the official names of this protein?
Uncharacterized 21.8 kDa protein.
Protein: GLO2_PROMM
Sequence: MEATSTAATSDKQRSSIHALPVLQDNIIWIWIKGNQAVVVDPAIAEPVKTWLRTRKLSLAAVLQTHHHADHIGGTLELLRDWPNAAVVAAAEDRDRIPFQTISVRDRDKVSLLNSSVEVLAVAGHTRAHIAYYLPTNKEDLEDPAVFCGDTLFGAGCGRLFEGTAEDMFKALQRLSCLPAKTRVYCAHEYTEANLRWASALHPEDVAISERLADVSSRRQRGALSLPSSISEEQRTNLFVRAQSSKELAELRHHKDQWRN
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: GPMA_STRPS
Sequence: MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIKFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAAEQFGDEQVHIWRRSYDVLPPNMDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERALPFWEDKIAPALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDEKLNVVSEYYLGK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: STC2_MOUSE
Sequence: MCAERLGQFVTLALVFATLDPAQGTDSTNPPEGPQDRSSQQKGRLSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIQGLHGICMTFLHNAGKFDAQGKSFIKDALRCKAHALRHKFGCISRKCPAIREMVFQLQRECYLKHDLCSAAQENVGVIVEMIHFKDLLLHEPYVDLVNLLLTCGEDVKEAVTRSVQAQCEQSWGGLCSILSFCTSNIQRPPTAAPEHQPLADRAQLSRPHHRDTDHHLTANRGAKGERGSKSHPNAHARGRTGGQSAQGPSGSSEWEDEQSEYSDIRR
What is the function of this protein?
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
What are the official names of this protein?
Stanniocalcin-2, STC-2.
What is the protein family that this protein belongs to?
Belongs to the stanniocalcin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNFE_PSEA8
Sequence: MSEQDFREIARNGLWRNNPGLVQLLGLCPLLGTSNSTVNALGLGLATMLVLACSNAAVSLVRGAVSEAIRLPAFVMIIAVLTTCIELLMQAWTYELYQVLGIFIPLITTNCVILGRAEAFAAKNGVLRASFDGLLMGLGFALVLLVLGGLRELLGQGTLLADMHLLFGPAAADWKIQPFPQYQGFLLAILPPGAFIMLGLLIALKNRIDESLAERAKVQAGDVPATQRQRVRVTGVIE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TTC1_BOVIN
Sequence: MGEKSNCRVPEDLFTGLKVTDPQEAECLHPPVSSGKEQHSQSELLKDVDAQPQEDQGEEECFHDASASFETEEPGADKLENKPEDDMNPSELDEEYLMELEKNMPDEEKKRRREESSRLKEEGNEQFKKGDYIEAESSYTRALQTCPSCFQKDRSVLFSNRAAARMKQEKKEMAISDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSVHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR
What are the official names of this protein?
Tetratricopeptide repeat protein 1, TPR repeat protein 1.
Protein: RUNX1_RAT
Sequence: MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQYLGSITSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQFPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSTSRYHTYLPPPYPGSSQAQAGPFQTGSPSYHLYYGTSAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVETEGSHSNSPTNMPPARLEEAVWRPY
What is the function of this protein?
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters.  The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis.  Isoform AML-1L interferes with the transactivation activity of RUNX1.  Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter.  Inhibits KAT6B-dependent transcriptional activation.  Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3.  Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (By similarity).  Positively regulates the expression of RORC in T-helper 17 cells (By similarity).
What are the official names of this protein?
Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B.
What are the subcellular locations of this protein?
Nucleus.
Protein: TM164_HUMAN
Sequence: MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQTKEDGRGSPGSQPEQVTQRPEEGKESLSKNLLLVALCLTFGVEVGFKFATKTVIYLLNPCHLVTMMHIFLLACPPCRGAIVVFKLQMHMLNGALLALLFPVVNTRLLPFELEIYYIQHVMLYVVPIYLLWKGGAYTPEPLSSFRWALLSTGLMFFYHFSVLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID
What is the function of this protein?
Positive regulator of ferroptosis.  Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death.
What are the official names of this protein?
Transmembrane protein 164.
What is the protein family that this protein belongs to?
Belongs to the TMEM164 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NDUS5_GORGO
Sequence: MPFLDIQKRFGLNIDRWLTIQSAEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, Complex I-15 kDa, CI-15 kDa, NADH-ubiquinone oxidoreductase 15 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFS5 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.
Protein: GBLP_HYDVU
Sequence: MEQMTLRGTLKGHNGWVTQIATTPQNPDLILSASRDKTLIQWQLTRDDQTNYGFPKKCLTGHNHFVSDVVLSSDGQFALSCSWDKTLRLWDLNQGITTKQFVGHTKDVLSVAFSADNRQIVSGSRDNTIKLWNTLGQCKYTIQDESHSEWVSCVRFSPNTQNPIIVSCGWDKMVKVWNLTNCKLKTNHFGHTGYLNAVTVSPDGSLCASGGKDGNAMLWDLNEGKHLYTLDGGNVINALCFSPNRYWLCAATGPMIKIWDLEMKSVVDELKPGVIGISTKSRAADCISLAWSADGQTLFAGYTDNLIRVWQVTRSSQ
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-like protein, Receptor of activated protein kinase C, RACK.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
Protein: SURE_PSEMY
Sequence: MRILISNDDGVNAPGIAALHQALADYAECVVIAPAEDRSGASSALTLDRPLHPMALSNGYISLNGTPTDCVHLGLNGLLEQTPDMVVSGINLGANLGDDVLYSGTVAAALEGRFLARPAFAFSLLSRLPDNLPTAAYFARKLVEAHERLELPPRTVLNVNVPNLPLEHIRGVQLTRLGHRARAAAPVKVVNPRGKEGYWIAAAGDVEDGSQGTDFHAVMQGYVSITPLRLDRTFNEALETMDGWLEGIF
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROP1_MACFA
Sequence: MAQTDKPTCIPPELPKMLKEFAKAAIRAQPQDLIQWGADYFEALSRGETPPVREQSERVALCNWAELTPEVLKILHSQVAGRLIVHAEELAQMWKVVNLPADLFNSVMNVGRFTEEIEWLKFLALACSALGVTITKTLKIVCEVLSCDHNGGLPRIPFSTFQFLYTYIAEVDGEISASHVSRMLNYIEQEVIGPDGLITVNDFTQNPRVWLE
What is the function of this protein?
Important for male fertility.  With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
What are the official names of this protein?
Ropporin-1, Rhophilin-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the ropporin family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.
Protein: RL31B_NEIG1
Sequence: MKPNIHPDNYRTVLFFDSSANEGWLIRSCAGTHGKTMVWTDGKEYLLFSLDTSSSSHPVYTGKQRNVNTEGRASKFNQRFQSVMSSFRKDK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.