PharMolix/UniProtQA huggingface dataset:
Protein: PYC_ASPTN
Sequence: MAAPYRQPEEAVDDSEFIDDHHDHLRDTVHHRLRANSAIMQFQKILVANRGEIPIRIFRTAHELSLQTVAIFSHEDRLSMHRQKADEAYMIGHRGQYTPVGAYLAADEIVKIALEHGVHLIHPGYGFLSENADFARKVEKAGMVFVGPTPDTIDSLGDKVSARQLAIRCNVPVVPGTEGPVERYEEVKAFTDTYGFPIIIKAAFGGGGRGMRVVRNQADLRDSFERATSEARSAFGNGTVFVERFLDKPKHIEVQLLGDNHGNVVHLFERDCSVQRRHQKVVEVAPAKDLPTDVRDRILSDAVKLAKSVNYRNAGTAEFLVDQQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGATLEQLGLTQDRISTRGFAIQCRITTEDPSKGFSPDTGKIEVYRSAGGNGVRLDGGNGFAGAIITPHYDSMLVKCTCRGSTYEIARRKVVRALVEFRIRGVKTNIPFLTSLLSHPTFVDGNCWTTFIDDTTELFALVGSQNRAQKLLAYLGDVAVNGSSIKGQMGEPKFKGEIIKPKLLDAQGKPLDVSHPCTKGWKQIIDQEGPVAFAKAVRANKGCLIMDTTWRDAHQSLLATRVRTIDLLNIAHETSHALSNAYSLECWGGATFDVAMRFLYEDPWDRLRKMRKAVPNIPFQMLLRGANGVAYSSLPDNAIYHFCKNAKKCGVDIFRVFDALNDVDQLEVGIKAVHAAEGVVEATVCYSGDMLNPKKKYNLEYYLALVDKIVALKPHVLGIKDMAGVLKPQAARLLVGSIRERYPDLPIHVHTHDSAGTGVASMIACAQAGADAVDAATDSMSGMTSQPSIGAILASLEGTEHDPGLNSAHVRALDSYWAQLRLLYSPFEANLTGPDPEVYEHEIPGGQLTNLIFQASQLGLGQQWAETKKAYEVANDLLGDIVKVTPTSKVVGDLAQFIVSNKLSAQDVIDRAAELDFPGSVLEFLEGLMGQPFGGFPEPLRSRALRNRRKLDKRPGLYLEPLDLAAIKNQIREQFGSATEYDVASYAMYPKVFEDYKKFVQKYGDLSVLPTRYFLAKPEIGEEFHVELEKGKMLILKLLAIGPLSEQTGQREVFYEVNGEVRQVSIDDKKASIDNTARPKADVGDSSQVGAPMSGVVVEIRVHDGLEVKKGDPLAVLSAMKMEMVISAPHSGKVSGLLVKEGDSVDGQDLVCKITKA
What is the function of this protein?
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
What are the official names of this protein?
Pyruvate carboxylase, Pyruvic carboxylase, PCB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_ANADF
Sequence: MTERLKLTGLVLRAVDYGESDRVVTLLTRERGKVSGFARGARASRRRFGGALEPFTLLVAEARERPGSDMLGLESVSVLRAHGGIRGELARIACAGYAAELSRELVRDHEPHAELLALLLEYLGALDAGPARPEGLRAFELGALRAAGLMPRVDACVACGGALGPEGRVRFDPGQGGVLCPPCAPAAAPGAPWVSIAAASALARLQAEGLAGASAALPPSVGREARDALAAFLEHHLGRRLAARRFLDEVGPLLGD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: UL38_HCMVM
Sequence: MTTTTHSTAAIMSLLDEAEWRQTQMDVGGLIQASALGKVALRYAVRKLMKRGARLRHDSGLYVCICDPSYEFLQMNLSKISWLERHCPPLDQELIMFGVIEAWEEASVRPTRQLVLFMTPKWDVFAYDSGILFFLAPSMAQFWHGAIVLEYWNALFPVEVRSHVRQHAHTMDDLVMVFHQLDYEKQVLEARRDKNTEGPRTFAKSVNSYVRAILESERRIREGKIPMTFVDRDSLRANSLAHIQATGAQPSHAPAQRVLSAPPSLPSPVSEEDPAAAATPPSSAATTPPSSVVPASVESELSSSPPLPPVVVKDVMYTAGEGDVVQMVVVV
What is the function of this protein?
Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication.  Promotes stabilization and inactivation of host TP53 through interaction with host MDM2 (By similarity).  Induces host mTORC1 activation by antagonizing the ability of host TSC1/2 to negatively regulate mTORC1 (PubMed:21715486).  Thus, inhibits a growth regulatory pathway to facilitate viral replication.  Prevents premature cell host cell death by blocking host ubiquitin-specific protease 24/USP24-mediated autophagic ferritin degradation in lysosomes thus maintaining lysosome integrity and cellular viability (PubMed:29695420) (Probable).  Involved in the activation of host ENO2 leading to enhanced glycolysis and UDP-sugar metabolism in order to enable the expression of viral glycoproteins (By similarity).
What are the official names of this protein?
Apoptosis inhibitor UL38.
What is the protein family that this protein belongs to?
Belongs to the beta-herpesvirinae UL38 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=localized in the host nucleus at early times postinfection and then increases in both nuclear and cytoplasmic compartments during the course of infection.
Protein: MNTP_SALA4
Sequence: MHFTATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGLGILASKFVLEWNHWIAFVLLIFLGGRMIIEGIRGGSDEDETPLRRHSFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMIGRFIGPMLGKRAEILGGVVLIGIGVQILWTHFHG
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Probable manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLMD_SHISS
Sequence: MAQFYSAKRRTTTRQIITVSVNDLDSFGQGVARHNGKTLFIPGLLPQENAEVTVTEDKKQYARAKVVRRLSDSPGRETPRCPHFGVCGGCQQQHASVDLQQRSKSAALARLMKHEVSEVIADVPWGYRRRARLSLNYLPKTQQLQMGFRKAGSSDIVDVKQCPILVPQLEALLPKVMACLGSLQVMRHLGHVELVQATSGTLMILRHTAPLSSADREKLERFSHSEGLDLYLAPDSEILETVSGEMPWYDSNGLRLTFSPRDFIQVNAGVNQKMVARALEWLDVQPEDRVLDLFCGMGNFTLPLATQAASVVGVEGVPALVEKGQQNARLNGLQNVTFYHENLEEDVTKQPWAKNGFDKVLLDPARAGAAGVMQQIIKLEPIRIVYVSCNPATLARDSEALLKAGYTIARLAMLDMFPHTGHLESMVLFSRVK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: SLUR1_HUMAN
Sequence: MASRWAVQLLLVAAWSMGCGEALKCYTCKEPMTSASCRTITRCKPEDTACMTTLVTVEAEYPFNQSPVVTRSCSSSCVATDPDSIGAAHLIFCCFRDLCNSEL
What is the function of this protein?
Has an antitumor activity (PubMed:8742060).  Was found to be a marker of late differentiation of the skin.  Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884).  In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity.  In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431).  In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989).  Seems to have an immunomodulatory function in the cornea (By similarity).  The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896).
What are the official names of this protein?
Secreted Ly-6/uPAR-related protein 1, SLURP-1, ARS component B, ARS(component B)-81/S, Anti-neoplastic urinary protein, ANUP.
What are the subcellular locations of this protein?
Secreted.
Protein: GRPE_METNO
Sequence: MTPNDTENAARPLPEGAVDPAQDAAGAPDTLAPAAQADAVAALEAEKLDLKNKLLRALADMENLRRRTEREVADARTYAVTNFARDMLNVADNVRRALDSVPVEDRAAADGALKALLDGIELTGRDLAKTLERHGVRAVEPQGQRFDPNLHQAMFEVPNPDVANGTVVQVVQTGYVIGDRVLRPALVGVSKGGPKAAEASKPAGEAPKPAGEAPKPAGDGQKPAEA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSJ_SALCH
Sequence: MTTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERKMPGVTLISASQTGNARRVAEALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQGEGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDTSYEFFCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDVLKSRAPVAAPSQSVATGAVNDIHTSPYTKDAPLIATLSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVDGKTLPLAEALEWHFELTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPIVDMVRFSPAQLDAEALIGLLRPLTPRLYSIASAQAEVESEVHVTVGVVRYDIEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPQTPVIMIGPGTGIAPFRAFMQQRAAEGAEGKNWLFFGNPHFTEDFLYQVEWQRYVKEGMLNRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDARRMAADVEKALLEVIAEFGAMDIEAADEFLSELRVERRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: SDHA1_ARATH
Sequence: MWRCVSRGFRAPASKTSSLFDGVSGSRFSRFFSTGSTDTRSSYTIVDHTYDAVVVGAGGAGLRAAIGLSEHGFNTACITKLFPTRSHTVAAQGGINAALGNMSEDDWRWHMYDTVKGSDWLGDQDAIQYMCREAPKAVIELENYGLPFSRTEEGKIYQRAFGGQSLDFGKGGQAYRCACAADRTGHALLHTLYGQAMKHNTQFFVEYFALDLLMASDGSCQGVIALNMEDGTLHRFRSSQTILATGGYGRAYFSATSAHTCTGDGNAMVARAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGILRNSEGERFMERYAPTAKDLASRDVVSRSMTMEIREGRGVGPHKDHIYLHLNHLPPEVLKERLPGISETAAIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGEVVTIKGDDPDAVIPGLMAAGEAACASVHGANRLGANSLLDIVVFGRACANRVAEISKPGEKQKPLEKDAGEKTIAWLDRLRNSNGSLPTSTIRLNMQRIMQNNAAVFRTQETLEEGCQLIDKAWESFGDVQVKDRSMIWNSDLIETLELENLLINASITMHSAEARKESRGAHAREDFTKREDGEWMKHTLGYWEDEKVRLDYRPVHMDTLDDEIDTFPPKARVY
What is the function of this protein?
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial, Flavoprotein subunit 1 of complex II, FP.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: MTNX_BACAN
Sequence: MSIQVFCDFDGTITNNDNIMSIMEKFAPPEAEEVKNRILSQELSIQEGVSQLFQLIPTNLHDEIIQFLIETAEIRNGFHEFIQFVNENNISFYVISGGMDFFVYPLLQGLIPKEQIYCNETDFSNEYITVNWPHPCDRLCQNHCGLCKSSLIRKLSDTNDFHIVIGDSITDLQAAKQADKVFARDFLITKCEENHISYTPFETFHDVKTELKHLLEVKL
What is the function of this protein?
Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase, HK-MTPenyl-1-P phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MtnX family.
Protein: RL3_BURCM
Sequence: MMSLGLVGRKVGMTRIFTAEGDSIPVTVLDVSDNRVTQIKTVETDGYTAVQVAFGSRRASRVTKPLAGHLAKAGVEAGEILKEFRIDAAKAAELSNGAVVGADLFEVGQKVDVQGVSIGKGYAGTIKRYNFSSGRATHGNSRSHNVPGSIGMAQDPGRVFPGKRMTGHLGDVTVTVQNLEIARIDAERKLLLVKGAIPGAKGGKVFVTPAVKTKGAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PTH_ALKOO
Sequence: MHIIVGLGNPGKKYDATRHNIGFEAIDMLAKRNNIEVKKLKHKALCGEGTIGGNKVLLVKPQTFMNLSGQSLLDIVQFYKVDPKNIVVLYDDIDIPVGTLRIREKGSSGTHNGMKSIIYLLQTDQFPRIRIGVGKPQFGDLADYVLGRFPKEEIPTMLETLERASQAVETLVKDGIAVSMNRYNG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_MARMS
Sequence: MDFRRYFLWGALFISGYLLFLQWSQDYGPQSTQSVAQSTQSQSETNSQMSDDLPMATQSTTEANAEIPQSVTKIAPGKLIEVTTDTLRVAINPVGGDLVEAALLQYKKELGQPDPFVILEDGSERTYVTQSGLVGQDGPDASPEGRPVYQSEKTAYTLADGENSLDVNLYYTDAKGVKYTKTFRFMKGKYRIRQLITVDNTSSNTWRGNLFAQIKRDNTPDPSKATSMGLQPYLGGAISDEQTKYTKVSFSDMKEDPIKTTTTKGWVAVLQHYFVSAWIPEQGQKVTLQARTNGDFNIIGFTGTSVEIAPGKQGTLSSTFYVGPKLQDHLESTAENLDLTVDYGWLWWLAKPLFWLLTLIQSFVINWGIAIILIVVCVKAIFFKLSAASYRSMAKMRKFGPEIAKLKEKYGDDRQKMSQEMMALYKKEKINPLGGCLPILVQMPVFLSLYWVLMESVELRHAPFFLWIHDLSVMDPYFILPILMGISMFVQQSLNPTPPDPMQARIMKIMPVAFSIFFLWFPAGLVLYWVTNNTLSILQQYVITKRIENEA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: WECG_KLEP3
Sequence: MTGTISAPLYLLRGLQLIGWRDMQHALDYLYADGALREGTLVAINAEKMLAVEDNPEVRALIEAAEFKYADGISVVRSLRKKYPQAQVSRVAGADLWEALMQRAGAEGTPVFLVGGKPEVLTQTESRLRQRWQVNIVGSQDGYFTPEQRQTLFERIRDSGAKIVTVAMGSPRQEIFMRDCRRLYPHALYMGVGGTYDVFTGHVHRAPKFWQDLGLEWFYRLLLQPSRIKRQFRLLRYLRWHYTGKL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: GP166_BPPH2
Sequence: MKLLTHVCHYCSFSFFTRKFDVFGAITKKDTPVVFCPTCGNQSLSVSHIEEEIR
What are the official names of this protein?
Gene product 16.6, gp16.6, Protein p16.6.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus gp16.6 family.
Protein: DXR_CLONN
Sequence: MKNICILGATGSIGTQTLDVIEKESNKFKLVAFSANKSYEKIITIIEKFNPVYGAINDKETFLKVKDHCNINNIKINLLYGMDGLIKISTLEEVELVVTSIVGMIGLVPTLEAINAGKDIALANKETLVTGGELVMKAAKQNNVKILPVDSEHGAIFQCLQGNSYKDIETIYVTASGGPFRQSKLEELINITPEQALKHPKWNMGKKISIDSSTMINKGLEVIEAHWLFNVGYDKIKVLVHPQSIVHSMVEYIDGSIIAQLASTDMRLPIQYALNYPVRNKKVVEKLDVYNMGNLTFEKPDFEKFRGLKLAYEAGKLGGIMPTIFNASNEVAVNMFLNNHIKYLEIVDIVEECMNKFENKSIKDVEDILNAEAKVRSFIKNKYNF
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RPOA_ILLOL
Sequence: MVREEIAVSTRTLQWKCVESRADSKRLYYGRFVLSPLMKGQADTIGIAMRRALLGEIEGTCITRAKSEKVPHEYSTIVGIEESVHEILMNLKEIVFRSHLYGTRGASICVRGPRYVTAQDIISPPSVKIVDTTQYIASLTEPIDLCIELQIERDRGYRIKTPNNYQDGSYPIDAVSMPVRNANHSIHSYGNGNEKQEILFLEIWTNGSFTPKEALYEASRNLIDLFLPFLHAEEQDINVEDNQNRATAPLFTFHDGLTNIGKRKKGIALKRVFIDQSELPTRTYNCLKRSNIHTLLDLLSNSQEDLMRIEHFRIEDVKQILGILQKRFAID
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BLAI_STAAU
Sequence: MANKQVEISMAEWDVMNIIWGKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTFLNKLYGGDMKSLVLNFAKNEELNNKEIEELRDILNDISKK
What is the function of this protein?
Transcriptional repressor that constitutively blocks expression of beta-lactamase.  Binds DNA as a dimer (By similarity).
What are the official names of this protein?
Penicillinase repressor, Beta-lactamase repressor protein, Regulatory protein BlaI.
What is the protein family that this protein belongs to?
Belongs to the BlaI transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT5_BACDO
Sequence: MCDDEASALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKVWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRTPEALFQPSFLGMESCGIHETVYQSIMKCDVDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin-5, muscle-specific.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: H33_PINPS
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPTTGGVKKPHRYRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSHAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes.  Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NRAM_I77AA
Sequence: MNPNQKIITIGSICMAIGIISLILQIGNIISIWVSHSIQTGSQNHTGICNQRIITYENSTWVNQTYVNISNTNVVAGKDTTSMTLAGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPIGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDDGAVAVLKYNGIITETIKSWRKQILRTQESECVCVNGSCFTIMTDGPSDGPASYRIFKIEKGKITKSIELDAPNSHYEECSCYPDTGTVMCVCRDNWHGSNRPWVSFNQNLDYQIGYICSGVFGDNPRPKDGKGSCDPVNVDGADGVKGFSYRYGNGVWIGRTKSNSSRKGFEMIWDPNGWTDTDSNFLVKQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPREKTTIWTSGSSISFCGVNSDTVNWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: MVP_TBRFV
Sequence: MALVKGKVNINEFIDLSKSEKFLPSMFTPVKSVMISKVDKILVHEDESLSEVNLLKGVKLIDGGYVHLAGLVVTGEWNLPDNCRGGVSVCLVDKRMERADEATLASYYTAAAKKRFQFKVVPNYNITTKDAEKAVWQVLVNIRNVKIAAGYCPLSLEFVSVCIVYKNIIKLGLREKITSVTDGGPMELSEEVVDEFMEEVPMSVRLAKFRSKTGKKFSSKSENNSGNNRPKPDKNQRKEKGLKVRVEKDNLIDNELETYVADSDSY
What is the function of this protein?
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding.  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier.  Forms a ribonucleoprotein complex with viral RNA.  Binds microtubules and modulates microtubule stability.  Can bind double-stranded DNA.  Evades host resistance (R) protein (e. g.  tomato ToMV resistance protein TM-2(2), AC Q71BG9) in ToMV/TMV resistant plants (PubMed:28107419).
What are the official names of this protein?
Movement protein, 30 kDa protein, Cell-to-cell transport protein.
What is the protein family that this protein belongs to?
Belongs to the tobamovirus movement protein family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton. Host cell junction, host plasmodesma. Note=Binds to the host cytoskeleton before being transported to the host plasmodesmata.
Protein: NUOM_PSEAE
Sequence: MILPWLILIPFIGGFLCWIAEHSSKTLPRWIALLSMTLVLILSLWIWATGDFQLAPAPGGEPEWTLQFKVLWIERLGISIHLAMDGLSLLMVALTGLLGVLSVLCSWNEIQRRIGFFHLNLLWILGGVIGVFLAIDLFLFFFFWEMMLVPMYFLIALWGHSSDDGKKTRIYAATKFFIFTQASGLVMLVAILGLVFVNFNATGVITFDYATLLKTQLSPHVEWLLMLGFFVAFAVKMPVVPVHSWLPDAHAQAPTAGSVDLAGILLKTAAYGLIRFALPLFPNASAEFAPIAMWLGIIGIFYGALLSFAQTDIKRLVAYSSVSHMGFVMIGIYSGSQVALQGVVVQMIAHGLSAAALFILCGQLYERLHTRDMRKMGGLWSRMPYLPAISLFFASASLGLPGTGNFVGEFLILIGAFKVVPVIIVIATFGLVFASVYSLIMIHRAYFGPSQSDEPILGLDARELSMVLGLAVLLVLLGVYPQPVLDISAASMHGVQQWLGAALSTLAGR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit M, NADH dehydrogenase I subunit M, NDH-1 subunit M.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.