PharMolix/UniProtQA huggingface dataset:
Protein: COQ2_AEDAE
Sequence: MLRKLTSNSSRWTTTHLGSLWQEVGGHPIRRGLILHHHCRPLAAVSSGVILRQKEESRWSPNSGGKLANLRCWPEYRLHSATKRRTLGELVLRDYSSNNISDKKPEPKSLLQSIVQNPYARLMRIDRPIGSWLLFWPCGWSIALSAPAGCWPDLWTLTLFGAGAFIMRGAGCTINDMWDRDIDGKVARTRNRPLVAGELTSADAWFFLGAQLGVGLLILLELNWYSIVLGASSLGLVIIYPLMKRITHWPQLVLGMTFNWGALLGWSATQGSVMWSACLPLYVAGVCWTIVYDTIYAHQDKVDDALLGIKSTAIRFGDNTKLWLSGFSTAMIGGLVASGMVCEQTWPYYSAVGVISAHLAHQIYSLNIDNPTDCATKFISNHQVGLILFLGIVLGTLYKGYSQRAGKSSTTSSSSTSSSSSPSSGLLLAATNHHQPARQAS
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
What are the official names of this protein?
4-hydroxybenzoate polyprenyltransferase, mitochondrial, 4-HB polyprenyltransferase, Coenzyme Q biosynthesis protein 2, Para-hydroxybenzoate--polyprenyltransferase, PHB:PPT, PHB:polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Protein: Y9770_BRUA1
Sequence: MSDKTPRKPTAFRLEQPARVSAASEQEEPRRPRAVKDLEQITPQADVFDLTDDEAAELEILDPAFEAPERKGWSLSRILFGALGILVSFAIGIWTEDLIRALFARADWLGWTALGVAMVALAAFAAIILRELVALRRLASVQHLRKDAADAAERDDMAAARKAVDALRTIAAGIPETAKGRQLLDSLTDDIIDGRDLIRLAETEILRPLDREARTLVLNASKRVSIVTAISPRALVDIGYVIFESTRLIRRLSQLYGGRPGTLGFIKFARRVIAHLAVTGTIAMGDSVIQQLVGHGLASRLSAKLGEGVVNGLMTARIGIAAMDVVRPFPFNAEKRPGIGDFIGDLARLNSDRNARK
What are the official names of this protein?
UPF0283 membrane protein BAbS19_I09770.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CP3A9_RAT
Sequence: MDLIPNFSMETWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYRKGFWEFDKYCHKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGSEEGKPTSMKDIFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKENRMKEKEKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALFRVLQNFSFQPCKETQIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA
What is the function of this protein?
This isozyme seems to be implicated in olfaction.  Active in the demethylation of erythromycin as well as benzphetamine.
What are the official names of this protein?
Cytochrome P450 3A9, 3AH15, CYPIIIA9, Cytochrome P450 olfactive 3, Cytochrome P450-OLF3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: PUR5_BURMA
Sequence: MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYREPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLALMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQHAWPLPPLFQWLQQHGGVADAEMHRVFNCGIGMAVIVSAADADDALRQLADAGEQVWKIGTVRASREGEAQTVVV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRP8_HUMAN
Sequence: MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR
What is the function of this protein?
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes.  The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.  In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.  Its substrates are however unknown.
What are the official names of this protein?
Ribosomal RNA-processing protein 8, Cerebral protein 1, Nucleomethylin.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RRP8 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Localizes at rDNA locus.
Protein: ARGC_VIBVU
Sequence: MLKTTIIGASGYTGAELALMVEKHPELTLAGLYVSANSTDAGKCISQLHGKLAGVIEMPVLPLTDPLGVAQDSDVIFLATAHEVSHDLAPLFLQQGCQVFDLSGAFRVKGDDFYTQFYGFAHQHSEWLDKAAYGLAEWNEEAIKASQLVAVAGCYTTAAQLAIKPLLISQLVDTNQWPVINATSGVSGAGRKASMTNSFCEVSLQPYGIFNHRHQPEIVHHLGCDVIFTPHLGNFKRGILATITMKLQDGVTKEQVAHAFAQAYDRKPAVRLKGDVIPRIQDVEFTPFCDLGWRVQGQHIIVISAIDNLLKGASSQAMQCLNIHYGFSPLTALL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYLT2_MOUSE
Sequence: MVASARVQKLVRRYKLAIATALAILLLQGLVVWSFSGLEEDEPGEKGRQRKPRPLDPGEGSKDTDSSAGRRGSAGRRHGRWRGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGRQNLSGAAAGEALIGAPGFPQHGDTGSVEGAPQPTDNTFTPKCEIVGKDALSALARASTKQCQQEIANVVCLHQAGNLMPKSVPRHCQLAGKMSPGVQWEEIRAQQPVGGPPVRIAYMLVVHGRAIRQLKRLLKAVYHEQHFFYIHVDKRSNYLYREVVELAQHYENVRVTPWRMVTIWGGASLLRMYLRSMKDLLEIPGWTWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDNSRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYTDDPLVAQLRQFYTYTLLPAESFFHTVLENSPACASLVDNNLRVTNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFLRLQQVSRPTFFARKFESTVNQEVLEILDFHLYGSYPPSTPALKAYWENIYDVADGPGGLSDVLLTAYTAFARLSLRHAATAVSPLATAVCRFEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEMWLMPQRSLKLLGHSDQASRLQSLEVGTEWDPKERLFRNFGGLLGPLDEPVAMQRWARGPNLTATVVWIDPTYVVATSYDITVDADTEVTQYKPPLSLPLRPGAWTVRLLQFWEPLGETRFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQGLSGILNLPQAEALEEAARRHTELTGSALEAWTDGELSNFWSVAGLCAIGPSACPSLELCRLTSWSSLSPDPKSELGPVKADGRLR
What is the function of this protein?
Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (PubMed:17517600).  Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity).
What are the official names of this protein?
Xylosyltransferase 2, Peptide O-xylosyltransferase 2, Xylosyltransferase II.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 14 family. XylT subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.
Protein: ASSY_DICTD
Sequence: MEREKVVLAYSGGLDTSVAIKWLMQKYSLDVITLTVDIGQGIDLNEIKNKAENLGVEKAYVLDLREEFIKDYIIPAIKSNAMYERVYPLATALSRPLIAKYLVKVAKENGAKYVAHGCTGKGNDQVRIDLGVKALAPDLEIIAPVREWNFSREEEIEYAIENNIPIPVSRKNPYSIDENLWGRSIEGGILEDPWQEPPEDIYLWTKLENKEPSYIEITFEKGIPVKLNGVEKDLVGLIEELNKIAGSYGIGRIDHIENRLVGIKSREIYEAPAALVIIKAHEALEDLVLPRELAHFKRMLEDKYAELVYYGLWFDPFREALQAFMDKTQERVTGKVKIKLIPWSFSIVGRDSPYSLYDHSLATYDKGSTFSTESAVGFIKLFGLQNYLYALKGGKNA
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARSR_BACSU
Sequence: MDETKSELLRKYEQKFKALADQKRLEIMYELCQRGKTCVCDLTEIFEVTQSKLSYHLKILLDANLITKETKGTWSYYDLNDEEVNGLLSEELCCIFRKKGEGDCC
What is the function of this protein?
Transcriptional repressor for the ars operon.
What are the official names of this protein?
Arsenical resistance operon repressor.
Protein: RBL1_RHOPA
Sequence: MNEAVTIRGKERYKSGVMEYKKMGYWEPDYEPKDTDVIALFRVTPQDGVDPIEAAAAVAGESSTATWTVVWTDRLTAAEKYRAKCYRVDPVPNSLGQYFAYIAYDLDLFEPGSISNLTASIIGNVFGFKPLKALRLEDMRLPIAYVKTFQGPATGIVVERERMDKFGRPLLGATVKPKLGLSGRNYGRVVYEALKGGLDFTKDDENINSQPFMHWRERFQYCMEAVNKAQAQTGEIKGTYLNVTAATMEDMYERAEYAKELGSIIVMIDLVIGYTAIQSMAKWARKNDMILHLHRAGHSTYTRQRNHGVSFRVIAKWMRLAGVDHIHAGTVVGKLEGDPATTKGYYDICREDFNPMTLENGLFFDQHWASLNKLMPVASGGIHAGQMHQLLHLLGEDVVLQFGGGTIGHPMGIAAGATANRVALEAMILARNEGRDYLHEGPEILAKAAQTCTPLKAALDTWKNVTFNYESTDTPDYAPTPSVSV
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: ATPB_CAMJD
Sequence: MQGFISQVLGPVVDVDFNDYLPQINEAIVVNFESEGKKHKLVLEVAAHLGDNRVRTIAMDMTDGLVRGLKAEALGAPISVPVGEKVLGRIFNVTGDLIDEGEEIPFDKKWAIHRDPPAFEDQSTKSEIFETGIKVVDLLAPYAKGGKVGLFGGAGVGKTVIIMELIHNVAFKHSGYSVFAGVGERTREGNDLYNEMKESNVLDKVALCYGQMNEPPGARNRIALTGLTMAEYFRDEMGLDVLMFIDNIFRFSQSGSEMSALLGRIPSAVGYQPTLASEMGKFQERITSTKKGSITSVQAVYVPADDLTDPAPATVFAHLDATTVLNRAIAEKGIYPAVDPLDSTSRMLDPNIIGEEHYKVARGVQSVLQKYKDLQDIIAILGMDELSEEDKLVVERARKIEKFLSQPFFVAEVFTGSPGKYINLEDTIAGFKGILEGKYDHLPENAFYMVGNIDEAIAKAETLREISRGDTCLDNCKVEQKKAN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL2_BIFLS
Sequence: MAIRVYKPTTAGRRNASVSDFSELTRSTPEKSLVRKKSKTGGRNSYGRITSRHRGGGHKRQYRLIDFKRWDKDGVPAKVAEIEYDPNRSARIALLHFADGEKRYIIAPKGIKQGDVIETGAQADIKPGNNLPLKNIPTGTVVHAIELRPLGGAKIARSAGAAVQLVAKDGAYAQLRMPSGEIRNVDARCRATVGEVGNEDHANIQLGKAGRARWIGHRPITRGESMNPVDHPHGGRTRGGKPPVSPWGKGEVRTRRPKKASNKMIVRRRPSGKNRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: TCPA_TETPY
Sequence: MAPSVGILGERDQGQDVRTNNVTAVMAIANIVKSSLGPQGLDKMLVDDVGDVTITNDGATILRQLEVQHPAAKVIVELSQLQDKEVGDGTTSVVILAAELLKRANELIKNKVHPTSIITGFKIAAKEACTYIKEHLAISVEELGREALINAAKTSMSSKLIGPESNLFSQIVVDAVESVKMTNLMGDTKYPIKNVKIIKSHGQSTLQSQLIRGYVLQTQRCDQQMKTRIEKAKIALLDFNLNKFRLQMGIQILVNDPKNLEKIRFKECEILKERCKKIIEAGANVIITSAGMDDVATKYLVEAGVMGLRRVDKHDLRRLAKATGGTIVTTLATPEGDEVFEASYLGECAEVYEEAVGDNDCIFFKGTKRANCASIIIRGANEFMVDEVDRSLHDSLCVVKRTLESGYVVPGGGAVEIALSIKLEDFARTLGTKEQTAVAEFCEALNIIPKVLAANAAQDATELVSKLRALHAASQSSDDPAKKELKNCGLDLSLGKVRNNVKAGVLEPMVSKIKSLRFATEAAITILRIDDMIKLNPQNEELPQGRH
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  Known to play a role, in vitro, in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit alpha, TCP-1-alpha, CCT-alpha.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y273_CHLTR
Sequence: MVEIFNYSTSVYEKHSSTNKLVNDFRKEIQMEGAAIRDIAKHAQILDMTPKPSALSTLMQTNKKTCWASFSPPTNFHKQRFSTPYLVPSLGSPDKQDQDMEKISSYLKVLTRGKFSYRSTADTLSRKNKRSSDQKRNGQHFEQEELEVEEEVLVREGTVLLRALDQGIKSSNLLIDYVISRIFQFVQG
What are the official names of this protein?
Uncharacterized protein CT_273.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0422/CT_273/TC_0545 family.
Protein: PAR1_HUMAN
Sequence: MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
What is the function of this protein?
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.  May play a role in platelets activation and in vascular development.
What are the official names of this protein?
Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: REX_LISMO
Sequence: MMEETTKIPQATAKRLPLYHRYLKYLDESGKERVSSAELSEAVKVDSATIRRDFSYFGALGKKGYGYNVSYILDFFSKTLSQDKQTNVALIGVGNLGTALLHYNFMKNNNIKIVAAFDVDPAKVGSVQQDIPIYHLNDMEEIVRENGVEVVILTVPADEAQVTVDRLIEADVKGILNFTPARISVPKQVRVHHIDLTTELQTLIYFLENYPAKTE
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_ECO5E
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEIIKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOLD_BACHK
Sequence: MQTVRMTTAQALVKFLNQQYVEFDGKQQKFVKGIFTIFGHGNVVGLGQALEEDAGELEVYQGRNEQGMANAAMAFAKQKHRKQIMACTSSVGPGSANMITSAATASANNIPVLLLPGDVFATRQPDPVLQQIEQTHDLSISTNDAFRAVSKYWDRINRPEQLMTAMIQAMRVLTNPADTGAVTICLPQDVQGEAWDFPSYFFQKRVHRIERRLPTKASLADAVEMIKRKKKPVMICGGGVRYAEAAEELKQFAETFHIPFGETQAGKSAIESSHPYNLGGIGVTGNVAANTIAKEADLVIGIGTRFTDFTTASKQLFQNEEVEFLNINISEFHANKLDALKVIADAKEALLALIDELQEIDYQSSYTVEIADAKDAWETELSRLHNIRFTCQDFTPEVEGHFNENLNEYVDALGTQLTQTAVIGQINTLLDKDAIIVGAAGSLPGDLQRMWASRKPNTYHMEYGYSCMGYEVAGALGAKLAEPSKEVYAMVGDGSYQMLHSELVTSLQENKKINVLLFDNSGFGCINNLQMGNGMGSFGTEFRYRNQETRKLDGAIMKIDFAASAAGYGVKTYHVTSLEQLQEALIGAKKQTVSTLIDIKVLPKTMTNGYESWWHVGVAEVSKNQSVQAAYESKVSNLQQARSY
What is the function of this protein?
Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG).
What are the official names of this protein?
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase, THcHDO hydrolase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: TTRC_ARCFU
Sequence: MLWSYPEGFAYFNEFAQSIIWEPVAFSYALLISGADLLLLAALALLSGYLRRAIPMFLILGLSFFSVILLGPLADLALPHRATEILTRPHLASTEMHPGISVMALYGGLLWPLTFIVALIFALLYFSYPMHKKGGTFSFLSFGVKSEESYERLKPAMKVLAAILVPLSALWTIYPGMLFFSQTWIYAWKNWGLMLPMFFGETFITATGTALILYYLERMEDERIRYPLLQIHGAAAIALAGVLILQMFIWGMWGNPNFAAVVPMMQAAAVIFLLTFILTLVSAKYEAITPIVPVLALFGVVVNKWNLIINGQLISRAGMGVLEPELAPNWLAEAVSPIALAILLLVILSYIFPMEVEEDAA
What is the function of this protein?
Part of a membrane-bound tetrathionate reductase that catalyzes the reduction of tetrathionate to thiosulfate.  TtrC probably anchors TtrA and TtrB to the external face of the cytoplasmic membrane.  May transfer electrons from membrane quinol to TtrB (By similarity).
What are the official names of this protein?
Tetrathionate reductase subunit C.
What is the protein family that this protein belongs to?
Belongs to the NrfD family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PURA_DROVI
Sequence: MSTTIAVNGNHYQQLHQGRTSMYKSKVDVVLGAQWGDEGKGKVVDMLASEVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCISVIGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVNTHLRLFPSIKVDVDAELARYKDYVDKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNEIGDLLQTRGFEVGVTTKRKRRCGWLDIPLLKYTSLVNGYTCICITKLDILDTLPEIKVGVSYKRSSGDKLDHFPGTISELSDIEVEYAVLPGWQTSTEHIRNFKELPENAQNYVRFLESQLSVPVRWVGVGKGRESIINVH
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAY_PSEPF
Sequence: MSLSEARFHDLVDETQEKLEDIFDDSDLDIDMENSAGVLTVKFENGTQLIFSRQEPLRQLWLAAVSGGFHFDYDEESERWMCDKSEEQLGEMLERIVKQQAGTEFDFEGL
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: ENSA_BOVIN
Sequence: MSQKQEEENPAEETGEEKQDTQEKEGILPEKAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE
What is the function of this protein?
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.  When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.  Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity).
What are the official names of this protein?
Alpha-endosulfine, ARPP-19e.
What is the protein family that this protein belongs to?
Belongs to the endosulfine family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_LYSSC
Sequence: MKKNIQIAIDGPAGAGKSTIAKIVAEALDFTYIDTGAMYRAVTYKAMQQNIHLDDEAKLAEMLAASTIDLKPSPQGQLVFLDGHNVSADIRSNEVTSSVSQVAAHAKVRELLVAQQQKLAANGGVVMDGRDIATHVLKNAELKIFMSATVEERARRRFIDNQKRGIDSSLEKLQEEIALRDKKDSEREASPLIQAEDAIFLDTTALSIDDAAQAILKLAEEKML
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQIA_ECOL6
Sequence: MCEHHHAAKHILCSQCDMLVALPRLEHGQKAACPRCGTTLTVAWDAPRQRPTAYALAALFMLLLSNLFPFVNMNVAGVTSEITLLEIPGVLFSEDYASLGTFFLLFVQLVPAFCLITILLLVNRAELPVRLKEQLARVLFQLKTWGMAEIFLAGVLVSFVKLMAYGSIGVGSSFLPWCLFCVLQLRAFQCVDRRWLWDDIAPMPELRQPLKPGVTGIRQGLRSCSCCTAILPADEPVCPRCSTKGYVRRRNSLQWTLALLVTSIMLYLPANILPIMVTDLLGSKMPSTILAGVILLWSEGSYPVAAVIFLASIMVPTLKMIAIAWLCWDAKGHGKRDSERMHLIYEVVEFVGRWSMIDVFVIAVLSALVRMGGLMSIYPAMGALMFALVVIMTMFSAMTFDPRLSWDRQPESEHEES
What is the function of this protein?
Component of a transport pathway that contributes to membrane integrity.
What are the official names of this protein?
Intermembrane transport protein PqiA.
What is the protein family that this protein belongs to?
Belongs to the PqiA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: M1110_ARATH
Sequence: MSVLRRIPQDGTFHQEGPIHRLAKRRPRFIASFDLSAATDRWPVPVIYELMACLFGQTMASCIVNGALALNSCSLKSVTGRHDEVVFVAGQPLGYYGSWALFALSHHAIVWLAALRAYPHQTRPFLDYALLGDDIVIADRSVAKEYRSLLDALQVDISDAKSIVSETGCLEFAKRFWVKIMSKDLSPVSAKAVLESYFLVGTQQLAYKYKLSPKTCLRLNKAGYRVLGQMDTTLRPYPGVLVGFRRYLVSF
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg01110, ORF251.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HLAF_HUMAN
Sequence: MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEEFRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEITLTWQRDGEEQTQDTELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILRWEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSDRNRGSYSQAAV
What is the function of this protein?
Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation.  Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC).  In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides.  Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance.  Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952).  Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421).  Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270).  May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683).  May play a role in inflammatory responses in the peripheral nervous system.  Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).
What are the official names of this protein?
HLA class I histocompatibility antigen, alpha chain F, CDA12, HLA F antigen, Leukocyte antigen F, MHC class I antigen F.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Lysosome membrane. Note=For cross-presentation transits from the cell surface through endosomal pathway to lysosomes, where the peptide is generated from internalized exogenous antigen.