PharMolix/UniProtQA huggingface dataset:
Protein: CHZ1_MAGO7
Sequence: MASEETGVTAPGAQEVANAGVASEAKGKGKGPAQDTHDTEMDEDDEDDTEADEAEQVAEEVEDDGMDEIDSSNVLPSRTRGRKIDFAKAAAEQNLSVDDDEEDDDDDFNDPDAEDDKMDED
What is the function of this protein?
Forms a chaperone-bound H2A. Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A. Z histone replacement in chromatin.
What are the official names of this protein?
Histone H2A.Z-specific chaperone CHZ1.
What is the protein family that this protein belongs to?
Belongs to the CHZ1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOC_LIMF3
Sequence: MIDVNNFESMEIGLASPMKIRSWSYGEVTKPETINYRTLKPEKDGLFDERIFGPTKDFECACGRYKRARYNKRVCERCGVEVTSAKVRRERMGHIELAAPASHIWYFKGIPSRMGLVLDMSPRELEEVIYFASYVVLDAGDTGLEKKQLLSEPRYRELKEEYGNRFTAEMGAEAIQKLLADVDLAKEATELKAVLKEATGQKRTRAVRRLDILEAFLKSGNKPEWMVMDVIPVMPPDLRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLELNAPGIIVQNEKRMLQEAVDALIDNGRRGRPVAGPGNRPLKSLSHLLKGKQGRFRQNLLGKRVDYSGRSVIDVGPSMKMNQMGLPVPMAMELFKPFIIHELTKRNLATNVKAAKRMIDKRDEKVFDVLEDVIKEHPVLLNRAPTLHRLGIQAFEPILVSGKAMRLHPLVCAAYNADFDGDQMAIHVPLSDEAQAEARLLMLAAHHILSPRDGEPIVAPSQDMVIGNYYMTTEDKAREGEGMIFKDTNEARMAYRNGYVALQTRVGVLTSSFDKKPFTAEQRQKIMVTSVGKLLFNNIMPEDYTYINEPTADNLQNGVPDKYFLEPGEDIHAYLENAPLVPPFKKGFLSDIIADVYKIYKVTVTSQLLDRIKDLGYYESTISGLTVGIADVTDLKEKPEIIEKAHKQVALVTKQFRRGLITDNERYERVIGIWNDAKDEVQNKLIEHMDIHNPINMMSDSGARGNISNFTQLAGMRGLMASPSGKIMELPILSNFREGLSVLEMFISSHGARKGMTDTALKTANSGYLTRRLVDVAQDVIVREKDCGTDRGLEVTAITNGNEMIEPLYDRILGRYTMKSVFNPETGEKIVGKNVLLNEEMAQKIIDAGVQKVTIRSAFTCNTEHGVCERCYGRNAATGDQVEAGEAIGTVAAQSIGEPGTQLTLRNFHTGGVAGNDDITQGLPRIQEIVESRNPKGKATISEVTGQVVSIEENPAEQTKDVTIKGETDTRTYTLPITARIRVAEGDDIHRGRAINEGSIDPKEMIRVRDVLSTETYLLSEVQNVYRMQGIDLLDKHVEIMIRQMMRKVRVMDPGDTDVLPGELLDISQFRDANYQTLISGGIPATARPVILGITKAALETNSFLSAASFQETTRVLTDAAIRGKNDPLVGLKENVIIGKIIPAGTGMGAYRNIKPKEVSVNTGATDGAITSIREMEEQLKDQD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RL7A_BOVIN
Sequence: MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKSALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L7a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOCOS_DICDI
Sequence: MLIFIISIIITIASIIFLFETVFNKNSNTINNNNNSNNNNNNNNNNNNNNNNNKNNIKENNIDKNKEIKIKEKLILNNNDPKENDLKYKEEFNNFLNKFSKNQEYGYKDNLIDNELRNHYNNNNNNNNNNNNNNKDDQFPKLKDIVYLDHAASTLASMNQIEEISKELKNSMFCNPHSVNPIGLKTKEEVDSIRENILNYFNAPYRQYSVIFTSGCTDSLKKVGEYFAWTKNSKFYYSLESHNSLLGIREYACESIGGSSTTSFQPIPSLYFKCNNNQFNDILEIIGNNDDNNNESYSLFGYPGQCNYSGTKYPLELINRIQKKYPKCKVLLDAASLVSTSSFDLTKYPVDFMTISFYKMFGYPTGIGALIVKNDSGEKCLINKKYFSGGTVNVSMAQERFHVDRPSLSERLEDGTINFMNIISLKHGFNIINNQLGGIDNVKLHTFSLTQYCKEEMLKLYHSDNSKQQQLCIIYSDNHFKDSSKQGSIINFNIFRSNGELFGYNQVEKLASLSSIYLRTGCFCNPGACHGYLNLSKKDIEQHLKDGHVCWDSKDILNGKPTGSVRISFGYMNNFNDVYKFINFLKSNFINDHKFEKEVIKSNKKINNNLCDISDNISCSGSCGGSCGSSGSGIEDYQVQYSNNIKEEKEEEEKEEIENLKNEKDNDEVLLSEIYIYPVKSCSGHKVVNDKWELVPSGLKYDREWTIIDQSGNYINQKKLPILALIQTEIDLINDKLILTAPEMKVLSIPLSYYPISAFDQIQVCGDKVDGLLYGDKDFSNTSGSSAGSGGGGGGNIDNISEWLYQFIGKRCYLVRKSPESHRKSKVDSSNEISFANESPYLLINEESVSDLKKRIIKDNPDSVPSDWNWISKHSFRANFIITGGKAYQEDLWSQFQLISKQQNDTTQSSSSPLVFNSVGDCNRCKMICINQKMGIEEREPLSTLASYRRSGGKIIFGQHLNFADSIKRNNSHTNDTALSSNESSISSSNPIFLHVPSKLKVLSERY
What is the function of this protein?
Sulfurates the molybdenum cofactor.  Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
What are the official names of this protein?
Molybdenum cofactor sulfurase, MCS, MOS, MoCo sulfurase, Molybdenum cofactor sulfurtransferase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
Protein: O26D_CONVC
Sequence: MEKLTILLLVAAVLMSIQALNQEQHQRAKINLLSKRKAPAERWWRWGGCLLWFGRCTKDSECCSDSCDRTYCELARFPEGW
What is the function of this protein?
Inhibits voltage-gated ion channels.
What are the official names of this protein?
Conotoxin Vc6.13.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EX7L_LACH4
Sequence: MTDNKYLTVTDLNYYITQKFKNDPYLHKVFLQGELSNFRYRRNSHQYFSLKDEKSKINVVMFRSYFDKVKFKPEEGMKVYVVGYVSVYGPQGSYQFYAENMEPAGLGALYEQLKQLQAKLAKEGLFNPEHKRKLPRFPDKIAVVTSASGAVIHDIMVTANRRFPHAEIDLFPAQVQGDTAADSLVKAMRQIAAQGDEYDVMIIGRGGGSLEDLWSFNEEEVVRQVYAMPMPVISSVGHETDTTLCDLVADARAATPTAAAEYATPNLADELAGIHQLQSRLIAGMQNNINQKRDRLNRIKNSVIMREPTRLYDQQIQQVDLLKQRLQNSIQNKVNNSLQNYRLLKQRLLSVSPDKQIAGMEQQEKFLAKQLNDNMKHYLKNKRSDFSKIVQQLDDYSPLKTLERGFVYTTNEEGETVSSVDQIKKDDHLNLHFKDGEVTATVTEVKK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_MYCBO
Sequence: MGEVSAIVLAASQAAEEGGESSNFLIPNGTFFVVLAIFLVVLAVIGTFVVPPILKVLRERDAMVAKTLADNKKSDEQFAAAQADYDEAMTEARVQASSLRDNARADGRKVIEDARVRAEQQVASTLQTAHEQLKRERDAVELDLRAHVGTMSATLASRILGVDLTASAATR
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RR19_THAPS
Sequence: MSRSLKKGPFVAYHLLKKINKMNADGKKDVITTWSRSSTILPNMIGFTIAVYNGKQHVPVFISDQLVGHKLGEFVSTRTFKSHIKADKKTKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYY_CLOB1
Sequence: MSNVYDILKERGYIKQLTHEEEIRELLGKEKISFYIGFDPTADSLHVGHFLQMMVMAHMQKAGHRPIALVGGGTGMIGDPTGKTDMRKMMTKEQIEHNCNCFKKQLAKIIDFSEDKAIMVNNADWLLNLNYIEFLREIGVHFSVNKMLTAECFKSRLEKGLSFLEFNYMLMQGYDFLELNRKYNCVMELGGDDQWSNILAGVDLIRRKESKSAYGMTFTLLTNSEGKKMGKTESGALWLDPEKTSPYEFYQYWRNVADADVEKCLRLITFLPMDEVRRLSSLEGAEINEAKKVLAFEVTKLIHGEEEAQKAKIAAEALFGGNAKDLGNMPTAYIDKNDLNNLLVDLLVKCEILPSKSEARRLIKQGGLYLNDEKVTDMNLVVTEEHVTEDGIMIRRGKKNFNRIVVE
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIP39_RAT
Sequence: METCQMSRSPRERLLLLLLLLLLVPWGTGPASGVALPLAGVFSLRAPGRAWAGLGSPLSRRSLALADDAAFRERARLLAALERRRWLDSYMQKLLLLDAP
What is the function of this protein?
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation.  Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization.  May inhibit cell proliferation via its action of PTH2R activation.  Neuropeptide which may also have a role in spermatogenesis.  May activate nociceptors and nociceptive circuits.
What are the official names of this protein?
Tuberoinfundibular peptide of 39 residues, TIP39, Parathyroid hormone 2.
What is the protein family that this protein belongs to?
Belongs to the parathyroid hormone family.
What are the subcellular locations of this protein?
Secreted.
Protein: VPP1_XENLA
Sequence: MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEVKKANISILDTGENPEVPFPRDIIDLEANFEKIEIELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEESSTLLEPSEMGRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAQIENPLEDPVTGDSVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMATGVNTRIEDLQMVLNQTEDHRQRVLQAAAKSLRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVADLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNLVDAYGIGSYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVVRESRILSQKIDNELFSMMFSGRYIILLMGLFSTYTGLIYNDCFSKALNLFGSSWSVRPMFTDTWSEDLLKHTSVLQLNPNVTGVFNGPYPFGIDPIWSLATNKLTFLNSFKMKMSVILGIIHMIFGVALSVLNHIYFKKPLNIYLSFIPEMIFMTTLFGYLVILIIYKWCAYDVSTSMVAPSLLIHFINMFLFSYQDTSLPMLYKGQMGLQCFLVVCAIICVPWMLVLKPLILRRQYLRRKHLGTHNFGGIRVGNGPTEEDAEIIQHDQLSMHSDEEEEFDFGDTVVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVMHIGLNIRSLGGGIALVFIFSAFATLTIAILLIMEGLSAFLHALRLHWVEFRNKFYMGTGFKFLPFSFETIWEGKFDD
What is the function of this protein?
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  Required for assembly and activity of the vacuolar ATPase (By similarity).
What are the official names of this protein?
V-type proton ATPase 116 kDa subunit a1, V-ATPase 116 kDa subunit a1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase 116 kDa subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Melanosome.
Protein: RLMF_PSEU2
Sequence: MTDTRKPPRKKPQRPAKPAAPREKATLHPRNRHQGQYDFAKLIKSSPELAAFVILNPYGKESIDFANPQAVRVFNRALLKAFYGIAHWDIPADYLCPPIPGRADYLHFLADLLAEDNEGVIPRGASIKALDIGTGANCIYPLLGHSDYGWQFVGSDIDSTAIAAATTIVKANGLSKAISVRQQANRRQILLGLLDSSERFHVSLCNPPFHASLEEAQRGSQRKWRALGKADPKRKLPVLNFGGQSQELWCDGGEIGFITQLIQESALLPSQVAWFSTLVSKASNLPPIHSALKKAGALEVKVVEMGQGQKQSRFVAWTFLDKAQRAPG
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYEL_HALJT
Sequence: MPELPTDRLTAVIPPEETLLGYLLRLSRPRFWLYLGGPVIVGVSYAADGPGELFSPLAIALFLYFTIPGNVFLYGVNDIFDADIDEHNPKKDDGREVSYRGDSAVTAIVVASGALALLFALVLPTLGIVALLAWMALSVEYSAPPLRFKTTPFLDSISNGLYILPGVIGYAAIEGVAPPATAVVGAWLWAMGMHTFSAIPDIEPDREAGIQTTATFLGESNTYYYCVMCWLMAAFVFNFTHWVFGVLLLVYPGLVFGILGVGVDIDEAYWWYPAINTVVGMVFTLIALWVMLYG
What is the function of this protein?
Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR) (PubMed:25712483).  Acts as a bifunctional elongase/hydratase that catalyzes the elongation of lycopene by attaching a C(5) isoprene unit at C-2, as well as the hydroxylation of the previous end of the molecule (PubMed:25712483).  The enzyme acts at both ends of the substrate, and catalyzes the conversion of lycopene to the C(45) intermediate dihydroisopentenyldehydrorhodopin (DH-IDR) and the conversion of isopentenyldehydrorhodopin (IDR) to the C(50) carotenoid dihydrobisanhydrobacterioruberin (DH-BABR) (PubMed:25712483).  Can also catalyze the conversion of lycopene to tetrahydrobisanhydrobacterioruberin (TH-BABR) (Probable).
What are the official names of this protein?
Lycopene elongase/hydratase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NPC2_DEBHA
Sequence: MVAYKNIALLALTFTIASVESLSIVGARPYIDKALSVFDIKTPNSQSEKPEIILTFAGPDDKPVPGDSPIVQCEASVPQLLNLQSVVIDPNPPLRGENLTFVAKGVLSQDIEDGAYVEVDVRYGFIKLLHQTFDLCEEITKIDLECPISKGQQVIEKKVEIPAEVPPGKYIVSARAYTKDDIFITCLSAMVEFPPL
What is the function of this protein?
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
What are the official names of this protein?
Phosphatidylglycerol/phosphatidylinositol transfer protein, PG/PI-TP.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
Protein: CRTZ_PSEVU
Sequence: MLVNSLIVILSVIAMEGIAAFTHRYIMHGWGWRWHESHHTPRKGVFELNDLFAVVFAGVAIALIAVGTAGVWPLQWIGCGMTVYGLLYFLVHDGLVHQRWPFHWIPRRGYLKRLYVAHRLHHAVRGREGCVSFGFIYARKPADLQAILRERHGRPPKRDAAKDRPDAASPSSSSPE
What is the function of this protein?
Catalyzes the hydroxylation reaction from beta-carotene to zeaxanthin.
What are the official names of this protein?
Beta-carotene hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
Protein: NHAA_JANMA
Sequence: MTPNTSPGSTLPRAQVLAERAFSTLEKFLHIEAFSGVVLLLAAAAALIWANSPYADGYHHFWHTAVSFSIGSWSVSESLHFLINDGLMTIFFLVVGMEIRREIHEGALANMRLAALPLAAALGGVVVPALIYFILNPGGEAAHGWAVPTATDIAFAVGVLALLGRSIPSNVRVFLLALAIIDDIVAVLIIAVFYSGGMDYSGFIIAAVGILMVLGMQRIGIASAYPYVIPGAVLWFGLLKTGAHPTLAGVVLGLMTPVFAPHARTHPLELASKALKDLWNQTANSTPDPHHLAHPLKQLRRAQRDLLPPVSRVQMALHPYVAFGIMPLFALANAGVSLDGIDMSATGSMSVMLGVLIALVAGKPLGIIGASFLMVRMGWCALPPGVTWGGVCLVGLLAGIGFTMSIFIATLAFNDPNLLGAAKLGILLASLSAAVLGLAWGFFQAKRKQPAVA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVA_YERPY
Sequence: MIGRLRGIILEKQPPLVLLETNGVGYEVQLPMTCFYELPELGQEAIIFTQFVVREDAQLLYGFNNKQERALFRELIKVNGVGPKLALAILSGMSAQQFVGAVEREDITTLVKLPGVGKKTAERLVVEMKDRFKGLNGDLFNNTGDISLPTASPQTSDADIEAEAASALVALGYKPQEASRLVSKIAKPGADCETLIRDALRAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: CD209_CHLAE
Sequence: MSDSKEPRLQQLGLLEEEQLGGVGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSLSQGQSKQDAIYQNLTQLKVAVSELSEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKQQEIYQELSQLKAAVGDLPEKSKQQEIYQKLTQLKAAVDGLPDRSKQQEIYQELIQLKAAVERLCRPCPWEWTFFQGNCYFMSNSQRNWHNSITACQEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNHEGTWQWVDGSPLLPSFKQYWNKGEPNNIGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSGDEERLLSPTPTTPNPPPE
What is the function of this protein?
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates.  May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2.  Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells (By similarity).
What are the official names of this protein?
CD209 antigen, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN1.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: CBRB_SHIFL
Sequence: MSVSRRVIHHGLYFAVLGPLIGVLFLVLYIFFAKEPLVLLVIIQVLPLFLLLSITTGAIPALLTGVMVACLPEKIGSQKNYRCLAGGIGGVVITEIYCAVIVHIKGMASSELFENILSGDSLVVRIIPALLAGVVMSRIITRLPGLDISCPETDSLS
What are the official names of this protein?
Inner membrane protein CbrB.
What is the protein family that this protein belongs to?
Belongs to the CbrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YA60_ENCCU
Sequence: MRYLELGCISKTNKLFQKLQDLNPLLNIEIEAYSCKSSRRQRGRFVEKPLGYLLSALELRFPDYDFCGESWGSFRRKTLAEVLNEMTYSISTTHKNSDDVKEFVGFLEVILHRSVSLGGCEIFSYENRMGPFEDCLWYFSFLFFNKKQRRVVMLNAFMSRS
What are the official names of this protein?
Uncharacterized protein ECU10_0060/ECU11_2080i.
Protein: PSBA_SINAL
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVESPSING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, 32 kDa thylakoid membrane protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: V2R_HUMAN
Sequence: MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
What is the function of this protein?
Receptor for arginine vasopressin.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Involved in renal water reabsorption.
What are the official names of this protein?
Vasopressin V2 receptor, V2R, AVPR V2, Antidiuretic hormone receptor, Renal-type arginine vasopressin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Protein: APOE_GORGO
Sequence: MKVLWAALLVTFLAGCQAKVEQAVETEPEPELHQQAEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLAQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGTSAAPVPSDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.