PharMolix/UniProtQA huggingface dataset:
Protein: CX7A1_MOUSE
Sequence: MRALRVSQALVRSFSSSTRSHLENRVAEKQKLFQADNDLPVHLKGGGMDNVLYRLTMTLTLGGTAYCLYCLGWASFPHKK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7A1, mitochondrial, Cytochrome c oxidase subunit VIIa-heart, Cytochrome c oxidase subunit VIIa-H, Cytochrome c oxidase subunit VIIa-muscle, Cytochrome c oxidase subunit VIIa-M.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIa family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: HSLO_LISMF
Sequence: MSDYLVKALAYDGMARVYAAVTTETIKEAQRRHDTWSVSSAALGRTMTGTLFLGAMQKEDQKITVKIEGDGPIGPIVADSNAQGQIRGYVTNPHVHFSELNEAGKLDVRRGVGTSGMLSVVKDLGFGENFTGQTPIVSGEIGEDFTYYLATSEQINSSVGVGVLVNPDDTIEAAGGFMLQLLPGATDEIIDEIEKNLTALPTVSRMIEAGETPESILAKLAGGEDKLQILEKIPVSFECNCSKERFGSAIISLGKEEIRSMIEEDHGAEAECHFCRNTYDFSEEELEKLYEEAK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DB128_MACFA
Sequence: MKLFLVLIILLFEVLTDGARLKKCFNNVTGYCRKKCKVGEIHEIGCLSGKLCCVNDEENKKHVPFKKPHQQPVEKLSVQQDYVILPTITIFTV
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 128, Defensin, beta 128.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CP74_LINUS
Sequence: MASSALNNLVAVNPNTLSPSPKSTPLPNTFSNLRRVSAFRPIKASLFGDSPIKIPGITSQPPPSSDETTLPIRQIPGDYGLPGIGPIQDRLDYFYNQGREEFFKSRLQKYKSTVYRANMPPGPFIASNPRVIVLLDAKSFPVLFDMSKVEKKDLFTGTYMPSTELTGGYRILSYLDPSEPNHTKLKQLLFNLIKNRRDYVIPEFSSSFTDLCEVVEYDLATKGKAAFNDPAEQAAFNFLSRAFFGVKPIDTPLGKDAPSLISKWVLFNLAPILSVGLPKEVEEATLHSVRLPPLLVQNDYHRLYEFFTSAAGSVLDEAEQSGISRDEACHNILFAVCFNSWGGFKILFPSLMKWIGRAGLELHTKLAQEIRSAIQSTGGGKVTMAAMEQMPLMKSVVYETLRIEPPVALQYGKAKKDFILESHEAAYQVKEGEMLFGYQPFATKDPKIFDRPEEFVADRFVGEGVKLMEYVMWSNGPETETPSVANKQCAGKDFVVMAARLFVVELFKRYDSFDIEVGTSSLGASITLTSLKRSTF
What is the function of this protein?
Involved in the biosynthesis of jasmonic acid, a growth regulator that is implicated also as a signaling molecule in plant defense.  Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides.
What are the official names of this protein?
Allene oxide synthase, chloroplastic, Cytochrome P450 74A, Hydroperoxide dehydrase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: THII_SHESR
Sequence: MKFIVKLYPEIMMKSKPVRMRFTKMLETNIRNVLKKVDEDAKVQRQWDRIWVKVPNDKPELAQAFGERLACIPGIAHVVQVDEYSFTSVDDIYQQVLPVYRDQIAGKTFCVRVKRTGSHDFNSIEVERYVGGGLNQFTDAVGVRLKNPEVTVNLEIEGDKLYMVTKRIEGLGGFPMATQEDVLSLISGGFDSGVSSYQFIKKGARTHYCFFNLGGAQHEIGVKQVAYHLWKTYGESHKVKFVSVPFEPVVAEILEKIDNGQMGVVLKRMMMRTAARIAERMGIQAIVTGESLGQVSSQTLTNLNVIDRCTDMLILRPLIAMDKQDIINECRRIGTEDFAKSMPEYCGVISQKPTVKAVLAKVEAEETKFSEDLIDRIVEQAVAIDIREIAEQMNTRITETETVVAIDTNEVVIDIRAPEEEENKPLEIEGVEIKRIPFFKLATQFADLDKQKTYLLYCERGVMSKLQALYLIEQGYHNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TR3N_HUMAN
Sequence: MRDLSERRLGQPELKAEQQMPLEPVRARLSVGLACCCSHTTAEASSLEHGDKVFGQGFPSPLEEIKRLLKISRALQARSVPSTQEKAKCLSGEPGQPEGKGQETYPGPGKVEGKAEPAMRKDDVCPGMKCISG
What are the official names of this protein?
Putative uncharacterized protein TXNRD3NB, Thioredoxin reductase 2 intronic transcript 1, Thioredoxin reductase 3 intronic transcript 1, Thioredoxin reductase 3 neighbor gene protein, TXNRD3 neighbor gene protein, Thioredoxin reductase 3 new transcript 1.
Protein: RNFE_SHEFN
Sequence: MSKYSEIAAQGLWKNNPGLVQLLGLCPLLAVTATITNALGLGVATLLVLIGSNVLVSLVRDFVPKEIRIPVFVMIIAALVTCVQLLINAYAYNLYLSLGIFLPLIVTNCVIIGRAEAFASRNSLAHSAFDGLMMGLGFTAVLVVLGASRELLGQGTLFGGADLLLGDWASVLTIHVWHVDTPFLLAMLPPGAFIGMGLLIALKNVIDSRVNAMQPKVESVSVTRARITKVN
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPA_SHEWM
Sequence: MQLNSTEISDLIKQRIEQFEVVSEARNEGTIVAVSDGIIRIHGLADVMQGEMIELPGNRFAIALNLERDSVGAVVMGPYASLAEGDKVKTTGRILEVPVGRGLLGRVVNTLGEPIDGKGPIDNDGFSPVEMIAPGVIERKSVDQPVQTGYKAVDSMIPIGRGQRELIIGDRQIGKTALAIDAIINQKDTGIKCVYVAVGQKASTIANVVRKLEEHGALANTIVVVATASEAAALQYLAPYSGCSMGEYFRDRGEDSLIVYDDLSKQAVAYRQISLLLKRPPGREAYPGDVFYLHSRLLERASRVNAEYVEKFTKGEVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNSGLRPAVNPGISVSRVGGAAQTKIIKKLSGGIRSALAQYRELAAFSQFASDLDDATRAQLEHGERVTELMKQKQYAPMSVADQSVSIFSAEKGYLKSVELNKIGDFEASLLSYMNSEHADLMKTINETGNYNADIEGELKAGLDKFVETQTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MNTP_CAMC1
Sequence: MQLLLLSFALSMDSAALNMANGARYKSLGFGKILFIAFMLGFFQFLMPLLGYFLGISFAKFISSIDHFIAFFILCFLGFKMLKEACSSEVGESLSMDIKTIFVGAFATSIDALAVGVTLSFEAVSIFESALIIGIVCFALSLAAFYIGKFMGEILEKKALFLGGAILIFLGFKILITHLLEEGVL
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMPN_PLUXY
Sequence: MRLLICLTLLGLVCGNPVQLTDNSIALQNTYDNYVLPGESFPTFYDVQLFFDPEYEASFNGTVAIRVVPRIATQEIVLHAMEMEILSIRAYSDLPSDDNLNENLFSSYTLATDDTHLLKIQFTRVLDALQPITVEISYSAQYAPNMFGVYVSRYVENGATVSLVTSQLQPTFARRAFPCYDEPALKAVFRTTIYAPPAYNVVETNMPLRTDSLKSDRPGFTKHEFQDTLVMSSYLLAYLVSKFDYISNENNPTYDKSMKVFSRPGTQNTAEFALDFGQKNMVELEKYTEFPYAFPKIDKVAVPDFAAGAMENWGLVIYREIALLVQEGVTTTSTLQGIGRIISHENTHQWFGNEVGPDSWTYTWLNEGFANFFESFATDLVLPEWRMMDQFVINMQNVFQSDAVLSVNPITFEVRTPSQILGTFNSVAYQKSGSVIRMMQHFLTPEIFRKSLALYISRMSRKAAKPTDLFEAIQEVVDASDHSIRWRLSIIMNRWTQQGGFPVVTVRRSAPSAQSFVITQRRFLTDSTQESNTVWNVPLNWVLSTDVNFNDTRPMAWLPPQLAAEAVQVPGLQNAEWFIVNKQQTGYYRVNYDPENWRALAKVLNDTHEIIHLLNRAQLIDDSFNLARNGRLDYSLAFDLSRYLVQERDYIPWAAANAAFNYLNSVLSGSSVHPLFQEYLLFLTAPLYQRLGFNAATGEEHVTPFHRNIILNINCLHGNEDCVSTAETLLQNFRDNPTQTLNPDIQTTVFCSGLRGGDVDNFNFLWARYTATQDSSEQSILLNALGCTSNADRRDFLFSQVIASDSQVREQDRHSVLVSAINSGPDNMNAALDFVLENFANIQPNVQGLTGTTNILNAFARTLTTQEHANKIDEFSNKYANVFTAGEMASVAAIKENIAASITWNSQNAATVEAWLRKNFGTDGASTVSASITIIISAMVAIYNIL
What are the official names of this protein?
Aminopeptidase N, AP-N, Apn1, Microsomal aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: PTH_ACIC5
Sequence: MFLVVGLGNPGIEYQFTPHNAGFLAVDAIAAEHNAVVSNRRCQALTGKIQLGGREVILAKPETYMNLSGVAVSALVRELNADPVRDLLVLYDELDLPIGSIRVRERGSPASHNGARSICSALGTADWPRVRIGVGPSGEDDLFRKGKNYLLTPMRKADLATLDGALERTARAVETVVTRGIGVAMNEFNRRENNGPAA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_SYNSC
Sequence: MPAPAAKDQAWEAVIGLETHVQLGTDSKIFTAASTTFGDEPNTHIDPVVCGLPGTLPVLNQKVLEYAVKAAMALNLNIAEHSKFDRKQYFYPDLPKNYQISQYDEPIAEEGCIEVEVAEKGKDTYLKTIGIERLHMEEDAGKLVHAGSDRLAGSTHSLVDYNRAGVALAEIVSKPDLRTGREAAEYASEIRRIMRYLGVSDGNMQEGSLRCDVNISVRRGPDAPFGTKVEIKNMNSFSAIQKACEYEIKRQIKAYETGEPIVQETRLWDEGKQLTKSMRSKEGASDYRYFPDPDLGPIEVSADQRESWRAELPELPAAKRHRYADELGLSQYDARVLTDERPMADYFEAVVGAGADAKLAANWITGDIAAHVNSNRLSYAELPFRPEKLAEMVQLIDGGKISGKIAKEILPELLEKGGSPKAIVDERGLGIISDPAAIEAIVDELLGAHPDEVEAFRGGKTKLQGFFVGQLMKKTGGKADPKLANQILSKKLKV
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: KIF6_DICDI
Sequence: MDFENDQLYNWLQLANLESFYPNFIKKNVSCDSFLSFTMQDYGNVGITSLQDRKKLFHLLQQLKKQTPPISNTSSPVINSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSGLRQPTSTSSLLSNNNLMSTQTQQSSSSSSSSSLSSKSNSNSDFMQKAQQLLKQRELERQQYAKQQQQQQSTQTKYQSSLKDFDITSSNKNNNLDDFFEDDNLYSQQQQQQQQQQQQQDFEFEEEEEEEDQQQQYDEEEEEEEEYEEDFYKEDLGEIDDGNVLDISDDEPDPNSSCIIVEGSPDEEDDDVEYIPQNESLVNGFGSMKIQQQQQQQFQPLQQQQQQQQQQQQQFYQQQIQQQQQQQQQQQQQQVQQQQQQFNNFNYSGLNEEQIKYYQQQAQYQQQVQQAQQAAIQQAQQAAALAQASQQQLQQQEQQRQQASNFFLDMNEYGQRIRVCVRKRPLNKKEIAKSEKDIIEVLPKKDLIVNEPKTKLDLSKFIEKHKFTFDGVFDESANNYQVYLHTAYPLVDSIFHKGKATCFAYGQTGSGKTHTQMGQQGDGLYALAARDIFHRLETYFKDQLQVCISFFEIYGGKLFDLLNERKKLACRENELQNVVIVGLSEKHVTSPQELMNCIIDGNKIRSTGSTGVNSDSSRSHAILQISLKNIKTNKLHGKFSFIDLAGSERGSDTYDNDKQTRKEGADINKSLLALKECIRALDQSSKHTPFRQSTLTQVLKDSFVGNSRTVMIANISPNQSSSEHTLNTLRYADRVKELGTSESNSNKKPVATYNIPAPLPPPDHLKQNFNDPILIPSTTTTTTTTATAINSQQPIIQQTSQPVSKIKQPVKQQQESQIPQTPQQQQQQQPPQQQPQQQQYNIPQTPQQTQQQFNIPQTPKQQQPIQTQPPMSPPKIDFVNYHRNHVDQFADILKKELISINQFESSKGSIPLENYINNIEQFLDSKQLLINHLRGIIQQHQQQPIQQQQQQQQPIQQQQQSTPQPSQLQTPQQRERARSQLQPPKPSIYSSRN
What is the function of this protein?
Microtubule-associated force-producing protein that plays a role in organelle transport.  Its motor activity is directed toward the microtubule's plus end (By similarity).
What are the official names of this protein?
Kinesin-related protein 6, Kinesin family member 6, Kinesin-13.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TROPH_TALSN
Sequence: MAPNFPPIEEALPLHHDLFYDGKWQTPITDSRRETLNPSTGQVIGKIADASTTDVDKAVEAAHKAFLSWKKTTMAERQGYMRRAAAILREHAAELALVESYNTGNPVAAMVIDAERAANALDYFAGLIPMLRGEVLPGPFPTEDYLHYTVREPMGVVARFVASNHPFMFAGARMASVIAGGNTVIIKPPEQAPLSCLRLAELLENVFPPGVVNILPGGAECGQALTCHPLVRKVSLIGSVATGKIIMRNAGSLMKQTSMELGGKNALIAFPDADIDHLVRSVAAGMNFTWAGQSCGSTSRVFLHDSIHDEVLARVVEVVRKGFRPGLATDPTTTMGSLISKAAQDRVLNYIASAREEGARLVTGGGMFDDLAGTPVEGGFFVQPTIFADVTPDMKIAREEIFGPVMSVLRWSDESELIRIVNSTNYGLTGSIFTKDLATAQRMIRQVEAGFVWVNDVCKHFLNVPYGGIKDSGIGRDECIDELFAYTNIKSVNINLGGATHLGSRLSQAGQISNT
What is the function of this protein?
Aldehyde dehydrogenase; part of the gene cluster that mediates the biosynthesis of the tropolone class of fungal maleic anhydrides (PubMed:22508998, PubMed:24863423).  The pathway begins with the synthesis of 3-methylorcinaldehyde by the non-reducing polyketide synthase (PKS) tropA (PubMed:22508998).  3-methylorcinaldehyde is the substrate for the FAD-dependent monooxygenase tropB to yield a dearomatized hydroxycyclohexadione (PubMed:22508998, PubMed:24863423).  The 2-oxoglutarate-dependent dioxygenase tropC then performs the oxidative ring expansion to provide the first tropolone metabolite stipitaldehyde (PubMed:22508998, PubMed:24863423).  Trop D converts stipitaldehyde into stipitacetal which is in turn converted to stipitalide by the short-chain dehydrogenase/reductase tropE (PubMed:24863423).  The next steps involve tropF, tropG, tropH, tropI and tropJ to form successive tropolone maleic anhydrides including stipitaldehydic, stipitatonic and stipitatic acids (PubMed:24863423).
What are the official names of this protein?
Aldehyde dehydrogenase tropH, Tropolone synthesis protein H.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: BACC_BACAM
Sequence: MNLTDKTVLITGGASGIGYAAVQAFLNQQANVVVADIDEAQGEAMIRKENNDRLHFVQTDITNEPACQNAILSAVDKFGGLDVLINNAGIEIVAPIHEMELSDWNKVLNVNLTGMFLMSKHALKYMLKSGKGNIINTCSVGGVVAWPDIPAYNASKGGVLQTDAFYRPSIIAKHNIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRLGKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ
What is the function of this protein?
Part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase.  Catalyzes the dehydrogenation of the C7-hydroxyl group in the 4S-tetrahydrotyrosine (4S-H4Tyr) to yield anticapsin (epoxycyclohexanonyl-Ala).
What are the official names of this protein?
Dihydroanticapsin 7-dehydrogenase, Bacilysin biosynthesis oxidoreductase BacC.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: LACD1_ENTFA
Sequence: MKKISEQKRKHLENLVDDQGIIGALAIDQRGALKRMMGKYKEVTAQEISDFKVLVSRCLTPETSAILLDPEYGLAAAENRAQTSGLLLAYEKTGYDASTPGRLPDSLDVWSVKRLKEAGADACKFLLYYDVDESEAINERKKAYIERIGSECLAEEIPFFLEIVSYDANNSDSASKEYAKVKPHKVIEAMKEFSKDRYNVDVLKVEVPVNMNFVEGFGTESLYSQDEAQAFFNMQSEATQLPFIFLSAGVSATMFQETLKFAKKAGSSFNGVLCGRATWADGVLPFVQQGAEAAVAWLETTGKTNVEELNQVLRESAVSVFEKIQ
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase 1, D-tagatose-1,6-bisphosphate aldolase 1, Tagatose-bisphosphate aldolase 1.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: ALB1_CANGA
Sequence: MPSRNSINRPKLTVNLNRKNSSISKKRDQRERAGLLQPARSSADSKSGKVKSVPLDLYFEGQKDDHASAKGITNKTLSKKRAKKIERNIKYAQQRRLLTDATAKLEADMEIDIDQKKTKDAKPKTALEQVKEALWNAVEDTSNSGLIIENGQGTVLGGPYFP
What is the function of this protein?
Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.  Accompanies the pre-60S particles to the cytoplasm (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein ALB1.
What is the protein family that this protein belongs to?
Belongs to the ALB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DHQS_METLZ
Sequence: MTIQLPPILIRADHLQTYDERKAIVASALESGYTHIILRPEDEALRHLGRYTAILADGKNLMYSGERIGVLLNLTGAEEMEEAYSLKNAVPNLIISPENWKVIPLENLISRFQNAETSVYICVKTPEEARLAFQTMEVGCDGIVITPDGPADLAAFSGIRNDEYPIVDLETAVVTKISTLSLGDRVCIDTCSLLERGEGMLIGSQSSCLFLVCSESFESEYVNSRPFRVNAGAVHSYILCPDGTTKYLSEIASGNELLSRMPDGNLRTVNVGRVKIEIRPMLYIEAKAGGKTYSVVLQNAETIRLGTPSGAVSVSDLAIGDLVYVRLESGGRHFGHTMAETICEK
What is the function of this protein?
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
What are the official names of this protein?
3-dehydroquinate synthase, DHQ synthase, 3-dehydroquinate synthase II.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type DHQ synthase family.
Protein: NCPR1_ORYSJ
Sequence: MALALEAARSWAASVLPPELAAAAGGDPLAALAATAAALVAGVVILAVWFRSGGGAPPKAAAPPPRPPPVKIEADADADDGRKRVTVFFGTQTGTAEGFAKAMAEEARARYEKAVFKVVDLDDYAAEDEEYEEKLRKETIVLLFLATYGDGEPTDNAARFYKWFTEGKEKEVWLKDLKYAVFGLGNRQYEHFNKVAKVVDELLEEQGGKRLVPVGLGDDDQCIEDDFTAWKEQVWPELDQLLRDEDDTTGASTPYTAAIPEYRIVFIDKSDVSFQDKSWSLANGSGVIDIHHPVRSNVAVRKELHKPASDRSCIHLEFDISGTGLVYETGDHVGVYSENAIETVEQAEKLLDLSPDTFFSVHADAEDGSPRKGGGSLAPPFPSPCTLRTALLRYADLLNSPKKAALVALAAHASDLAEAERLRFLASPAGKDEYSQWVVASQRSLLEVMAAFPSAKPPLGVFFAAVAPRLQPRYYSISSSPKMAPSRIHVTCALVYGPTPTGRIHQGVCSTWMKNAIPSEYSEECSWAPIYVRQSNFKLPADPTTPIIMIGPGTGLAPFRGFLQERLALKQSGVELGNSVLFFGCRNRNMDYIYEDELQNFIQEGALSELIVAFSREGPAKEYVQHKMTEKATEIWNIVSQGGYIYVCGDAKGMARDVHRALHTIVQEQGSLDSSKTESYVKSLQMDGRYLRDVW
What is the function of this protein?
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes (By similarity) (PubMed:23053415).  It can also provide electron transfer to heme oxygenase and cytochrome B5 (By similarity).  Can reduce cytochrome c in vitro (PubMed:23053415).
What are the official names of this protein?
NADPH--cytochrome P450 reductase 1, CPR, OsCPR1, P450R.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the flavodoxin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single- pass membrane protein; Cytoplasmic side.
Protein: LDHA_ALLMI
Sequence: MSVKEHLIHNVHKEEHGHAHNKITVVGVGAVGMACAISILMKDLADELALVDVVEDKLRGEMLDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKHSPDCKLLVVSNPVDIWTYVAWKISGFPKHRVIGSGCNLDSARFRYLMGERLGIHSLSCHGWIVGEHGDSSVPVWSGVNVAGVSLKALHPELGTDADKEHWKEVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAETVMKNLRRVHPISTMVKGMYGIKDDVFLSVPCVLGYHGITDVVMMTLKSEEEEKLRKSADTLWGIQKELQF
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_BORDL
Sequence: MKKNLMLIFGGVSFEHEISLRSAYGIYSSLLKLDKYNVFSVFVDKVTGIWYLLDSVPSSAELIKRHTTSIVNFIPGCGIFVNNKSLEIDVIFPIIHGRTGEDGAIQGFVKMMDIPCVGAGILGSAISINKYFCKVLLKSFNIPVVSFIGFKKDDYILNKEGIKEDINNKLNYPVIVKPSVLGSSIGINVAYNVSQIEKYIEEAFEYDLTVVVEKFIKAREIECAVIGNDQIKIFTPGEIVVQDFIFYDYDAKYSTVPGDSIVFNIPAHLDMKHLLDIKEYAFLTYKYLELRGMARIDFLISKDTNLLYVNEVNTIPGFTDISMFAKMCEHDGLSYESLVDKLITLAFESYKKRKDKIDFTRLES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_LACLS
Sequence: MIEFEKPKITKFDESENYGKFVVEPLERGYGTTLGNSLRRVLLSSLPGAAVTSIQIEGVQHEFATIPGVREDVIQIVLAVKGIAIKSYVESEKQIELDVTGPMDVTAGDILTDSDIEIVNKDHYLFSIAEGHSMRAVMTVKKGYGYVPADENKVDGAPIGTIAVDSIYTPVSKVNYQVEPARVGGDSSYDKLTLEITTNGTIVSDEALSLSAKILTDHLNLFVDLSEVAAEAETLVVKDEVKTERVLDKIIEEMDFSVRAYNGLKRAGINTVTDIVEMSEADMIKVKNLGHKSVEEVKVKLTELGLSLKKRK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: BIOB_MYCTO
Sequence: MTQAATRPTNDAGQDGGNNSDILVVARQQVLQRGEGLNQDQVLAVLQLPDDRLEELLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSGLFASPVRSAWLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLMAQVAAGIEAIRNEVEINIACSLGMLTAEQVDQLAARGVHRYNHNLETARSFFANVVTTHTWEERWQTLSMVRDAGMEVCCGGILGMGETLQQRAEFAAELAELGPDEVPLNFLNPRPGTPFADLEVMPVGDALKAVAAFRLALPRTMLRFAGGREITLGDLGAKRGILGGINAVIVGNYLTTLGRPAEADLELLDELQMPLKALNASL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: NDHJ_ACAM1
Sequence: MADSSSESTQDEQSVAEEQAAPIIEAGPVAKHLTQAGFTVEALGADHLGVEMIKVTADQLVDVATTLVNDGYNYLMCQGGYDSGPGQELVSMYHLLKLSDDADRPPEVRIKVFLSREDPRVPSLYWVWKASDWQERESYDMYGIVYEGHPNLTRILMPEDWVGWPLRKDYISPDFYELQDAY
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J, NDH-1 subunit J, NDH-J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PG044_VACCW
Sequence: MATKLDYEDAVFYFVDDDKICSRDSIIDLIDEYITWRNHVIVFNKDITSCGRLYKELMKFDDVAIRYYGIDKINEIVEAMSEGDHYINFTKVHDQESLFATIGICAKITEHWGYKKISESRFQSLGNITDLMTDDNINILILFLEKKLN
What is the function of this protein?
Virulence factor that affects the acute immune response to infection (PubMed:23580427).  Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation.  Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation.
What are the official names of this protein?
Protein K7.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG044 family.