PharMolix/UniProtQA huggingface dataset:
Protein: REN_TYCSV
Sequence: MDLRTGEYITAHQATSGVYTFGITNPLYFTITRHNQNPFNNKYNTLTFQIRFNHNLRKELGIHKCFLNFHIWTTLQSPTGHFLRVFKYQVCKYLNNLGVISLNNVVRAVDYVLFHVFERTIDVTENHEIKFNFY
What is the function of this protein?
Increases viral DNA accumulation.  Enhances infectivity and symptom expression (By similarity).
What are the official names of this protein?
Replication enhancer protein, REn, Protein C3, Protein L3.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae replication enhancer protein family.
Protein: FER1_USTMA
Sequence: MVAPQRRTVMPALGLLASSLCSLLLTANAATVEQHWNINWVPDVNPDGLYPRHVIGVNGSWPPPIINVNASDTVRITATNKLETGVGASLHSHGMFFNRTGYYDGAVAITQCPIPPGQSFTYETLNSPASPADRRKQMGTFWIHAHNNDQYTDGLRSPVIIHPDDPADIHYNYDDDYTVILGDWYHSNYTDLVKNEFMNRKNPTGAEPVPKSGLIYFAHTSNKTSAATYLPGFSENATLPFEAGKTYRLRVINMSALAAFYFYLSGHDMQVIEVEGVDVLPQPVDFLSVAVAQRFSVLVTARNDTDPQNWKLHANMDEDMFDVVPEDLQLNVSATISYPNAPKDKFGPEKILEEYTYFDDLQFVPVNAEPMVTPDAVHRLDVSFDTMSDGENYAAFNNISYVAPQVPALFSAESMGALASNPAIYGPNSNAFVIKHNEMIEVQLFNWDAGKHPFHLHGHHFQVVHKSQDVTSDDPTINPPFNSSQVNPMRRDTVMVPPGGSAYLRFRADNPGAWFFHCHIDPHLVSGLASIFIEAPDVLSDSFLNVPSYIKNQCQAQGIATTGNAVGLNSTSDFDGLAKGPTYLESGWTGRAIAAFTGCIITGLLGLATVVVYGWHSGEEDDDEEEEDK
What is the function of this protein?
Iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake (PubMed:17138696).  May be required to oxidize Fe(2+) and release it from the transporter (PubMed:17138696).  Essential component of copper-dependent iron transport (PubMed:17138696).
What are the official names of this protein?
Iron multicopper oxidase fer1, Fe-regulated protein 1.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RECX_LACLM
Sequence: MGKITAIKKLKRLYRVDLSDLDEEKIYLCEDTIIHFFITIDKEVSETDLEEILAYDQFAQGKSLALYYISFKMRTGAEVRKYLLEHDINDTDQIEQVLSVLTENNLINDKSYAENFIEGKISMGSSGPYQIKQKLLTKGISNDVLSETLNEIYSEEKQIDVAYKLASKLSRTYGTRLTLKQLKDKIIQNLMNKGFSYSVSSIALDSLELEADEENEMDLLYSELDKVAKRYTKNYEGYERKQKITQALARKGFLYDDISSALRDYTFPE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAG_VILV2
Sequence: MAKQGSKEKKGYPELKEVIKATCKIRVGPGKETLTEGNCLWALKTIDFIFEDLKTEPWTITKMYTVWDRLKGLTPEETSKREFASLQATLACIMCSQMGMKPETVQAAKGIISMKEGLQENKEAKGEKVEQLYPNLEKHREVYPIVNLQAGGRSWKAVESVVFQQLQTVAMQHGLVSEDFERQLAYYATTWTSKDILEVLVMMPGNRAQKELIQGKLNEEAERWVRQNPPGPNVLTVDQIMGVGQTNQQASQANMDQARQICLQWVITALRSVRHMSHRPGNPMLVKQKNTESYEDFIARLLEAIDAEPVMDPIKTYLKVTLSYTNASTDCQKQMDRTLGTRVQQATVEEKMQACRDVGSEGFKMQLLAQALRPQGKAGHKGVNQKCYNCGKPGHLARQCRQGIICHHCGKRGHMQKDCRQKKQQGNNRRGPRVVPSAPPML
What is the function of this protein?
Encapsulates and protects viral dimeric unspliced genomic RNA (gRNA).  Binds these RNAs through its zinc fingers.  Acts as a nucleic acid chaperone which is involved in rearrangement of nucleic acid secondary structure during gRNA retrotranscription.  Also facilitates template switch leading to recombination.
What are the official names of this protein?
Gag polyprotein.
What is the protein family that this protein belongs to?
Belongs to the Ovine/caprine lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Matrix protein p16]: Virion. SUBCELLULAR LOCATION: [Capsid protein p25]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p14]: Virion.
Protein: RS13_ALKOO
Sequence: MARIAGVDLPRDKRVEVGLTYIFGIGRKTSNNILAAAGINPDTRIKDLTEEEVNNLRRIIDADHHVEGDLRREIALNIKRLKEIRCYRGIRHIKGLPVRGQKTKTNARTRKGPKKTVGRKKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RAD22_SCHPO
Sequence: MSFEQKQHVASEDQGHFNTAYSHEEFNFLQSSLTRKLGPEYVSRRSGPGGFSVSYIESWKAIELANEIFGFNGWSSSIRSINVDFMDENKENGRISLGLSVIVRVTIKDGAYHEDIGYGSIDNCRGKASAFEKCKKEGTTDALKRALRNFGNSLGNCMYDKYYLREVGKMKPPTYHFDSGDLFRKTDPAARESFIKKQKTLNSTRTVNNQPLVNKGEQLAPRRAAELNDEQTREIEMYADEELDNIFVEDDIIAHLAVAEDTAHPAANNHHSEKAGTQINNKDKGSHNSAKPVQRSHTYPVAVPQNTSDSVGNAVTDTSPKTLFDPLKPNTGTPSPKFISARAAAAAEGVVSAPFTNNFNPRLDSPSIRKTSIIDHSKSLPVQRASVLPIIKQSSQTSPVSNNSMIRDSESIINERKENIGLIGVKRSLHDSTTSHNKSDLMRTNSDPQSAMRSRENYDATVDKKAKKG
What is the function of this protein?
Active in the repair of DNA damage and in mating-type switching.  Probably involved in the repair of DNA double-strands breaks.  Has a role in promoting S phase completion.
What are the official names of this protein?
DNA repair and recombination protein rad22.
What is the protein family that this protein belongs to?
Belongs to the RAD52 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KEFG_ECO8A
Sequence: MMSQPAKVLLLYAHPESQDSVANRVLLKPATQLSNVTVHDLYAHYPDFFIDIPREQALLREHEVIVFQHPLYTYSCPALLKEWLDRVLSRGFASGPGGNQLAGKYWRSVITTGEPESAYRYDALNRYPMSDVLRPFELAAGMCRMHWLSPIIIYWARRQSAQELASHARAYGDWLANPLSPGGR
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefB.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefG, Putative quinone oxidoreductase KefG.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DER_RICB8
Sequence: MTKKIIAKKIIALVGRPNVGKSTLFNRLSMRKKAIVHDLPGVTRDRKYTDGRIGSFEFSLIDTPGFEENPDSFGKRLMEQTTKAINEADLICFMVDSRSGILPDDKLLSDFVRKYNKPAVLVINKCEKAFDFDKEYYKLGFDSMVAISAEHGTGMIDLYDEIIAKLPEEDSAEAEIHDPIKGDCLQIVVSGRPNAGKSTFINALINDERLLTGPEAGITRESIEIDWQYKGNHIKLIDTAGLRKKATITESLEKLSASDAINSIKFANTVILMIDALSPLKQQDLNIASHVANEGRSIVIVVNKWDLIKESEKEAFKEEFYYQINTTLPQVKGVPALFISAKNKQNIADVLDSCIKIYKTWNKKITTSKLNEWLNFTTEAHPLPLQKGGKRVRVKYMTQTKTRPPTFKLFSNNPEKITDSYTRYLVNNMREAFDMPGVPIRFNYIKTKNPYV
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ATF1_BOVIN
Sequence: MEDSHKSNTSETAPQSGSTVQAAHISHIAQQVSSLSESEESQDSSDSIGSSQKTHGILARRPSYRKILKDLSSEDIRGRKGDGENPGVSAVTSMSVPTPIYQTSTGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTSKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV
What is the function of this protein?
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters.  Mediates PKA-induced stimulation of CRE-reporter genes.  Represses the expression of FTH1 and other antioxidant detoxification genes.  Triggers cell proliferation and transformation (By similarity).
What are the official names of this protein?
Cyclic AMP-dependent transcription factor ATF-1, cAMP-dependent transcription factor ATF-1, Activating transcription factor 1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PANCY_NOSS1
Sequence: MRLLTTVAALRCYLNKRRWESRLTASEEQILDSMTSWYQTAIGLVPTMGSLHQGHLSLIERARHENSTVIVSIFINPLQFGPNEDYGRYPRTLEQDRQLCEQGGVDAIFAPSPEELGIPQKNIQESQVTQVIPPSVMISGLCGHSRLGHFQGVATIVTKLLNLVQPDRAYFGQKDGQQLAVIKRLVADLDLPVEIVACPTVREASGLACSSRNQYLTAQEKQQAAVLYRGLLQAEAAFKAGVRYSSRLREVVRQELAKVSSVLVEYIELVEPTTLMPLDKIQEEGMLAIAARLGSTRLIDNTILRDRQPIIAIDGPAGAGKSTVARQVATKLGLVYLDTGAMYRAVTWLVLQQGIAIDDDCAIAELASKCKIELTPSQDLQSPVRVWINDTDVTQNIRTIEVTSQVSAIAAQAAVRQALVKQQQRWGKRGGLVAEGRDIGTHVFPDAEVKIFLTASVGERARRRQQDFQKQGQPEVSLEQLEKDIAERDWKDSTRKVSPLQKAADAVELQTDGLSISDVASQIVDYYQQRLSQW
What is the function of this protein?
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.
What are the official names of this protein?
Bifunctional pantoate ligase/cytidylate kinase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_BARQU
Sequence: MEKNFKVAALYCFADLKHYRQLQKPLLDLCQAKDIKGTLLLAQEGINGTIAGSCRAIEELVNFIKTEPAFQTPEIKYSWASKMPFHRMKVRLKKEIVTMGVEGINPLKIVGTYVDPEDWNALIQDEETLLIDTRNDYEYAIGSFQGAIDPGIKTFREFPEWVRKHEADLKKKKKMAMFCTGGIRCEKSTAYVRELGYEQVYHLKGGILKYLETIPKEESLWWGECFVFDERVSVKHGLEECGRELCRACRSPLNAEGKLSPHYEAGVSCDACYNKRSEVDRERFRERHRQIQLSKLRAMHSHQE
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: LPXK_NEIMF
Sequence: MPNCFKFHTVIERHWQKPYPVLSFLLKPLSGLFAKIAAKRRTDFLSGKRQSEKLPVPVVVVGNIHAGGTGKTPIVAALVSGLQEKGVKVGIISRGYGRKSKAVHVLNAESRAEDAGDEPLLLFRKTGAPTAVGSSRAEAGRALLAAHPDIGLIVADDGLQHYALRRDVEIAVFPSADTGRTDLDLLPNGSLREPLLRLDSVDAVVVSGGKADALFRPSENMFHSRIEAGRIYRLNNPSEILDTGRLKNQTVVAVAGIAKPARFFDSLRNMGITVKRTVALPDHADISAADLPDADAVIITEKDAVKFSDGICTDNVWVLPVCAIIEPDLAAFVLERLEDVPKAV
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: RL21_METM5
Sequence: MQKSEGFRSKTRYKLQKHPRQKGMAPLTRALKCYTEGDRVHVVLDPSVQKGMPHPKFHGKTGVIVAQRGRSFLVRVKDGGKYKDIIARPQHLRESKL
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: FTSH_LEPBD
Sequence: MADRDKNDIRKRLEELRKDNNRRNNRQDNGNRSPFSGFLFFIFVILLFTFTLLFHRDIQTYFQEKREISYTEFVSKTQKGDFSEINEKDDKLISQVKENGKDVLYYTKKITDRVGDEPNIISAIGQKKVKLNSLQPSGGGFFLLLLGQFLPMIIMIGLMVYLAKKMVGGSQGGGPGNIFGFGKSRVNKIDKKPDVKFDDVAGVDGAKEELREVVDFLKNPEKYTKAGARVPKGVLLLGRPGTGKTLLAKAVAGESGASFFSISGSEFVEMFVGVGASRVRDLFEKAKESSPSIIFIDEIDAIGRRRSVGKNSGSNDEREQTLNQLLVEMDGFETDTKVIVLAATNREDVLDPALLRAGRFDRRVTVDAPDLQGRIAILKVHSRNKKLARDVKLEDIAKITPGFVGADLANLLNEAAILAARRASDTIKMADLDEAVDKIGMGLGQKGKIIKPEEKKLLAYHEAGHAIMTELTPGADPVHKVTIIPRGDAGGFMMPLPEEKLVTTSRQMLAEIKVLFGGRAAEEIGLEDVSTGAYSDIKRATKVARAYVESVGMSKKLGPINFENSDDEYSFTPNKSDETVREIDLEIRKILTEEYFNTLNTLQDNWEKLEQVVELLLKKETITGDEVRRIIAGEKAEDILKGTEVKEESIQKGSEGIVQTSENSIEESQENKTVEAEVHDSNLKSDTEKLAEAVREITGETGGVLEPTEKNDFDKDSDDNEKNDDDNENSDDSSKNDSDSDDENENSDNKSEKNKKRKSNFKLPSFME
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: Y3250_JANMA
Sequence: MSELDPTESLIEYPSDFPIKVMGLAHDQFVPTIIDVVVVHDPEFHEGRIEQRPSSAGNYLSLTVTVRATSREQLDNLYRALSSHPMVKYVL
What are the official names of this protein?
UPF0250 protein mma_3250.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: RIMO_SALPA
Sequence: MSNVTHQPKIGFVSLGCPKNLVDSERILTELRTEGYDVVPRYDDADMVIVNTCGFIDSAVQESLEAIGEALNENGKVIVTGCLGAKEDQIREVHPKVLEITGPHSYEQVLQHVHHYVPKPKHNPFLSLVPEQGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPIGDVLSEAKRLVDAGVKEILVISQDTSAYGVDVKHRTGFHNGEPVKTSMVSLCEQLSKLGVWTRLHYVYPYPHVDDVIPLMAEGKILPYLDIPLQHASPRILKLMKRPGSVDRQLARIKQWREICPELTLRSTFIVGFPGETEEDFQMLLDFLKEARLDRVGCFKYSPVEGAGANELPDQVPEEVKEERWNRFMQLQQQISAERLQEKVGREILVIVDEVDEEGAIGRSMADAPEIDGAVYLNGETNVKLGDIVRVKVENADEYDLWGSRV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL16_AOTTR
Sequence: MDYSFDTTAEDPWVRISDCIKNLFSPMMTENHSHMPLQPNASLSEDDGTQGHSDGTPPKLETANGTSKVYRPADSSAVKKGPPVAPKPAWFRQSLKGLRNRASDPRRLPDPALSTQPGPASREHPGPHTQASSSSSSSIKQRISSFETFGSSQRPDRGAQRLSLQLSSGEATKPVGKHEGGRLPGLLGRGAAPTLAPQETEQLLSSGSPAASEVRDPGVSESPPTGRQPSEKTLPPGPDPLLQLLSTQTEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSITWGQTPCIPREGASATSSSNADSAANGSAETSGSDTGFSLNLSELREYTEGLTEAKEADDGDHCSPQSGQSVISLLSSEELKKLIEEVKDLDEATLKQLDSIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHNDALAILRQAREPRQAVIVTRKPTPETAPDLNSSTDSAASVSAASDVSVDSTAEATVCTVTLEKMSGGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILHLAGTAMQGLTRFEAWNIIKALPDGPVTIVIKRKSMQSKGTPAAGDS
What is the function of this protein?
Pro-interleukin-16 is involved in cell cycle progression in T-cells.  Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene.  May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity).
What are the official names of this protein?
Pro-interleukin-16.
What are the subcellular locations of this protein?
[Interleukin-16]: Secreted. SUBCELLULAR LOCATION: [Pro-interleukin-16]: Cytoplasm. Nucleus.
Protein: PAL_LEGPN
Sequence: MKAGSFYKLGLLVASAVLVAACSKTPGSADGGAAVGDGDATAQGLGQMTHFAGQEPGESYTTQAPHNQLYLFAYDDSTLASKYLPSVNAQAEYLKTHPGARVMIAGHTDERGSREYNVALGERRADTVAEILRMAGVSRQQIRVVSYGKERPANYGHDEASHAQNRRVEFIYEATR
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity (By similarity).  Very strongly associated with the peptidoglycan.
What are the official names of this protein?
Peptidoglycan-associated lipoprotein, PAL, 19 kDa surface antigen, PPL.
What is the protein family that this protein belongs to?
Belongs to the Pal lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: SELO_SHIBS
Sequence: MTLSFVTRWRDELPETYTALSPTPLNNARLIWHNIELANTLSIPSSLFKNGAGVWGGEALLPGMSPLAQVYSGHQFGVWAGQLGDGRGILLGEQLLADGTTMDWHLKGAGLTPYSRMGDGRAVLRSTIRESLASEAMHYLGIPTTRALSIVTSDSPVYRETAEPGAMLMRVAPSHLRFGHFEHFYYRRESEKVRQLADFAIRHYWSHLEDDEDKYRLWFSDVVARTASLIAQWQTVGFAHGVMNTDNMSLLGLTLDYGPFGFLDDYEPGFICNHSDHQGRYSFDNQPAVALWNLQRLAQTLSPFVAVDALNEALDSYQQVLLTHYGQRMRQKLGFMTEQKEDNALLNELFSLMARERSDYTRTFRMLSLTEQHSAASPLRDEFIDRAAFDDWFARYRGRLQQDEVSDSERQQLIQSVNPALVLRNWLAQRAIEAAEKGDMMELHRLHEALRNPFSDRDDDYVSRPPDWGKRLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: IF3_PROM1
Sequence: MPPRPRFDRHAPERELPNINERISYSSLRVVDSDGTQLGVISREEALEVAKERELDLVLVSEKATPPVCRIMNYGKFKFEQEKKAKEAKKKSHQTEVKEVKMRYKIDQHDYQVRISQATRFLKAGDKVKCTVIFRGREIQHTALAETLLKRMSKDLEEKAEVQQSPKREGRNMIMFLTPRKTPLLKKESETTEPKKALRSIN
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_NEIG2
Sequence: MNLKSPLFLRLSDRLDVYIRLMRADKPIGTLLLLWPTYWALWLASDGIPDLAVLAAFTIGTFLMRSAGCVINDFADRDFDGAVERTKNRPFAQGRVKKKEALLLTAFLCLLAALCLIPLNHLTWLMSLPALFLALTYPFTKRFFPIPQFYLGLAFSFGIPMAFAAVGNSVPVEAWILFAANVLWTLAYDTVYAMADKEDDLKIGIKTSAVTFGRYDIAAVMLCHGGFTLLMAVLGAVIGAAWAYWTAIPIVLLLQYRQYAAIKSRVRQICFETFLANNRIGWVWFAAIFAHTFFAK
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SHRM4_MOUSE
Sequence: MESRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVNINGTPLYGSRQEALILIKGSFRILKLIVRRRNTPVSRPHSWHVAKLLEGCPDVATTMHFPSEAFSLSWHSGCNTSDVSVQWCPLSRHCSTEKSSSIGSMESLEQPGQPTYEGHLLPIDQNMYPSQRDSAYSSFSASSNASDCALSLKPEEPPSTDCVMPGPGPIKVTDDQANVSENSGSSHSTSEDHVTSTSHASSYSDEGHHSGPAKMARGPPEPPVRSDSLPASRAQLLNGEQHRASEPVDSLPQKEKPGLETVLPPRSSNQFCCLSGQDQVTDEDHQNCELSKPSESSQDDCEHLLIEDSSKALDSPKAHDKGSNKEFGLLKEASADLANTLNFGAIPHLRGTMEHRHSAPEQLLASHLQQVHLDSRGSKGMELPIGQDGHQWTVSPLHNNPKGKKSPSLPTGGTQDQTRKERKTTPLDDKLMASVHQSQSDVLLGEVDGHPNRAGRASSDLTSQQPSATCSSVQQTRDFLSAHKIVDHTEASEEGDNEPKECGRLGGRRSGGPRGRSIQNRRRSERFATNLRNEIQRRKAQLQKSKGPLSQLCDTNEAVEETQEPPESPPLSASNASLLPSYKNVPSPGDKVFNKSMILRARSSECLSQASESSKARGGVEGRMSPGQRSGQSSLALNTWWKASDSSTLDTEKANAHHGVCRGHWRWSPEHNAQPQVALSTEAPSNPDDSKELKTSTPQAGEEAVLMPFADRRKFFEESSKSLSTSHLPGLTTHNNKPFIQRQKPIDQNFQSVSYRDLRCHPLDQSYHSADQSYHAADQSYHSLSPLQSETPTYPECFATKGRDNSLCCKPVHHGDCDYHRTCSHPCSAQGTVRHDPCICCSGEICPALLKRNLLPKCHNCRCHHHQCIRCTGCCHGPQHSAHEDSSMAPGNAWKSRKAAIQEFPVDKWKPITGNRKTSHSGREMAHSKAGFSLSTPFRPCIENPALDLSNYRAVSSLDILGDFKRASNKPEESSVYEDENSVASMPRPLRSRAFSESHISLEPQNTQAWGKHQRESFSKGSETQPDTLGARKKVFPPPRPPPPNWEKYRLFRAAQLQQQQQQQQQQQQQQRCEEEEEKEQEEEGEKEEDLPPQYFSSELTGSCAPNTEEQPQSLKMGHQEASRQGSQSLQEQEAFALHPSNFVPPVRGCTVPQPEKAQHPCYYGTHGLWRTTEQEATVTPKQEFQHFSPPKGASGIPTSYSAYYNISVAKAELLNKLKQQPEMAEAGLGEEGVDYELAQKKIQLIESISRKLSVLREAQRGLLDDINANAALGEEVEANLKAVCKSNEFEKYHLFIGDLDKVVNLLLSLSGRLARVENALNSIDSESNQEKLVLIEKKQQLTNQLADAKELKEHVDGREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLKESLHLGPSNF
What is the function of this protein?
Probable regulator of cytoskeletal architecture that plays an important role in development.  May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II.
What are the official names of this protein?
Protein Shroom4.
What is the protein family that this protein belongs to?
Belongs to the shroom family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Shows partial colocalization with the cytoplasmic pool of F-actin.
Protein: H3A08_CYRHA
Sequence: MKASMFLALAGLVLLFVVGYASESEEKEFPRELLSKIFAVDDFTGEERGCKGFGDSCTPGKNECCPNYACSSKHKWCKVYLGK
What is the function of this protein?
Selective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC(50)=1270 nM on Nav1. 1/SCN1A, 270 nM on Nav1. 2/SCN2A, 491 nM on Nav1. 3/SCN3A and 232 nM on Nav1. 7/SCN9A).  This toxin suppress Nav1. 7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics.  Short extreme depolarizations partially activate the toxin-bound channel, indicating voltage-dependent inhibition of this toxin.  This toxin increases the deactivation of the Nav1. 7 current after extreme depolarizations.  The toxin-Nav1. 7 complex is gradually dissociated upon prolonged strong depolarizations in a voltage-dependent manner, and the unbound toxin rebinds to Nav1. 7 after a long repolarization.  Moreover, analysis of chimeric channels showed that the DIIS3-S4 linker is critical for toxin binding to Nav1. 7.  These data are consistent with this toxin interacting with Nav1. 7 site 4 and trapping the domain II voltage sensor in the closed state.
What are the official names of this protein?
Hainantoxin-III 8, HnTx-III, Hainantoxin-3.8, Mu-theraphotoxin-Hhn2a, Mu-TRTX-Hhn2a, Peptide F7-18.76.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 15 (Hntx-3) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RECR_ECODH
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQEVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLAEEKITEVILATNPTVEGEATANYIAELCAQYDVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PSD7A_ARATH
Sequence: MDVIKTQQISARTIEKVVVHPLVLLSIVDHYNRVAKDSSKRVVGVLLGSSSRGVVDVTNSYAVPFEEDDKDPSIWFLDHNYHESMFHMFKRINAKEHVVGWYSTGPKLRENDLDVHALFNGYVPNPVLVIIDVQPKELGIPTKAYYAVEEVKENATQKSQKVFVHVSTEIAAHEVEEIGVEHLLRDVKDTTISTLATEVTAKLTALKGLDARLREIRSYLDLVIEGKLPLNHEILYHLQDVFNLLPNLNVNELVKAFSVKTNDMMLVIYLSSLIRSVIALHNLINNKLLNKEHEKAEDSKPVAIPATS
What is the function of this protein?
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity).  Required for innate immunity.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 7 homolog A, 26S proteasome regulatory subunit RPN8a, AtRPN8a, Protein ASYMMETRIC LEAVES ENHANCER 3, Protein MOV34, AtMOV34.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family.
Protein: CRCB2_METHJ
Sequence: MEHLILVGIGGAVGAMLRFELSKLRPVRSIPLGTALVNIIGSSLFGCVVFSRSPGDIFYLVDVGILGGFTTFSTFSFETFRMFEEQDYQTMVLNISINLIGSLIGVLLSFILVTLILTGG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YQGF_LACPL
Sequence: MKLMGLDVGSRTVGVAISDAFGWTAQGVEIIRINEDAEEFGIDRVAELVEELDAGGFVLGLPKNMNNTLGPRAEAAQHYGELLTARFHLPVDFEDERLTTVEAERMLVEEANTSRKKRKKVIDKLAASLILQNYLDRHGKLTQE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.