PharMolix/UniProtQA huggingface dataset:
Protein: Y2946_DICDI
Sequence: MVRQIKILPKHSIGHNFSGFDKSYPEELYSSLPIIEYTQIIDYINLKTQRDYKSYILYMIIFAIFGLLPFLIALIFELFRSSLYKNRFERDFDNCLKQINELIKCRNVTFSFKFTSKIRKMQKLELIISYQDEQPKKEIVGDFIVSPEGRNILVLPPAPLDLINFDQLYLSSSQSNKFNKSKKSNKINDKTPILNNNNNNNNNNNIINYCKTKINYNNSERKTNGLKDDNFYGFKDTNYDKDLYNFMLESEYQSMIREFNTVLVRKIDIKKQLIFLLVSTILLIALIGFILIIPAAILYSKKRSHYYTHLYNDLNIMVHKYSSIYNSRGITISYCFENSDDFNNDSSPLINILIIYPKAPKGSPILTNFTNNTHQWILVPTSPNAIAPYFTILNNMAYNNNNSIIENNFNNNYNNSNNNNNSNNSNSNNNNNNNNNNNNYNNNNYNNNNNQVQVYQTEQTLNYNI
What are the official names of this protein?
Uncharacterized transmembrane protein DDB_G0294619.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CHDC_GEOTN
Sequence: MSEAAQTLDGWYCLHDFRTIDWSAWKMLPNEERQAAIDEFLALVDKWETTESEQQGSHAIYTIVGQKADILFMILRPTLDELHEIETALNKTKLAEYLLPAYSYVSVVELSNYLASGNEDPYQIPEVRRRLYPILPKTNYICFYPMDKRRQGDDNWYMLSMEQRRELMRAHGMTGRKYAGKVTQIITGSVGLDDFEWGVTLFSDDALQFKKLVYEMRFDEVSARFGEFGSFFVGNRLAAENVPTFFHI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: TGT_XENTR
Sequence: MAAPQCHALVHRVLAECPVTKARACEFRLPHGPVKTPVFMPVGTQGTMKGVTADQLRNLGCEICLGNTYHLGMRPGPEIMKKAGGLHGFMNWGRNLLTDSGGFQMVSLVELSKVTEEGVQFRSPYDGKEILLTPEKSIEIQNALGSDIMMQLDDVVSSTITGPRVEEAMHRSIRWLDRCIAANSNPDRQNLFAIIQGGLDAELRRKCLQEMTKRDVPGFAIGGLSGGEEKDHFWRMVTLSTDHLPRDKPRYLMGVGYATDLVVCVALGCDMFDCVFPTRTARFGSALVPWGSLQLKNKQFAKDFQPIDKNCDCPTCQRYSRAYINALFKSDTAAMHHITIHNIAYQLNLMRSVRDSILQGRFPQFVQDFMRTMYSSRDKYPQWAVDALETVGITLQ
What is the function of this protein?
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
What are the official names of this protein?
Queuine tRNA-ribosyltransferase catalytic subunit 1, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Weakly associates with mitochondria, possibly via qtrt2.
Protein: Y696_CHLMU
Sequence: MRLLILLLFSFGIIYSHGDEIPTQKQVLVSIVPYKFLVEQISGDTCQVFSIVMGNRDPHNYELPPKYIEKIRQADLWFRIGEGFERTCERIVSCKQVDLAANIDKIMNGSCCQRFLNFDTHTWLSPKNLKIQIESIAEALIAIAPEHADLYRKNCSLLQDQLDLLDQKVSSIVSQSSQRNVLVAHGAFAYFCRDYGFVQHTIERSNHSELSPKDIVRVEQTIRDHNLHSVVLLKHAGKRSSAALVRKFNMTPVLLDPYAEDVFSNLIAIATAFADL
What is the function of this protein?
Part of an ATP-driven transport system TC_0696/TC_0697/TC_0698 for a metal.  Metal-binding component.
What are the official names of this protein?
Uncharacterized periplasmic metal-binding protein TC_0696.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 9 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: UNG_MYCVP
Sequence: MTARPLSELIDDGWASALAPVESQVTQMGEFLRAELADGHRYLPAGENVLRAFTFPLEKVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPLPRSLDNIFREYREDLGYPTPSTGDLTPWCEQGVMLLNRVLTVRPGTPASHRGKGWEPVTECAIRALVARQQPMVAVLWGRDASTLKPMLGDTAVIESPHPSPLSASRGFFGSKPFSRANELLTQMGAEPVDWRLP
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1552_BACC7
Sequence: MAKIGVENSLTDVQQALQQQGHEVITINSEHDAQGCDCCVVTGQDSNMMGIADTSIKGSVINAHGLTTDEICQQVESRI
What are the official names of this protein?
UPF0180 protein BCAH187_A1552.
What is the protein family that this protein belongs to?
Belongs to the UPF0180 family.
Protein: NHAA_SHIBS
Sequence: MKHLHRFFSSDASGGIILIIAAILAMMMANSGATSGWYHDFLETPVQLRVGSLEINKNMLLWINDALMAVFFLLVGLEVKRELMQGSLASLRQAAFPVIAAIGGMIVPALLYLAFNYADPITREGWAIPAATDIAFALGVLALLGSRVPLALKIFLMALAIIDDLGAIIIIALFYTNDLSMASLGVAAVAIAVLAVLNLCGVRRTGVYILVGVVLWTAVLKSGVHATLAGVIVGFFIPLKEKHGRSPAKRLEHVLHPWVAYLILPLFAFANAGVSLQGVTLDGLTSILPLGIIAGLLIGKPLGISLFCWLALRLKLAHLPEGTTYQQIMAVGILCGIGFTMSIFIASLAFGSVDPELINWAKLGILVGSISSAVIGYSWLRVRLRPSV
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDK_OLEA2
Sequence: MAERTFAIIKPDATRRNLEGPILSVIQQNGLRVVAMKKMRLTREQAEGFYHVHKERPFFASLTDFMTSGPIVAMVLEGDNAVARWRELMGATNPENAAEGTIRRQFAEGLEANSVHGSDAAETAAFEMGYFFNAMEITG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 4EBP1_BOVIN
Sequence: MSGGSSCSQTPSRAIPTTRRVVLADGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPTGDEPPTEARQNHLRSSPEDKPAGGEESQFEMDI
What is the function of this protein?
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation.  In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.  Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the eIF4E-binding protein family.
Protein: KTU_DROVI
Sequence: MSASTRNKHSKIHGNEKLDITTDEFDRIRQALSNEEFRKLFFDYVDEIQDPENRKLYEKEITQLEKERGVDVTFIHPQPGFVVKTSIDGELKCFINIASSTVVERPNNEVSVNSQTGQKGLSWSIPMAQTPPRDDLDANNKQCKVFDVVFHPDALHLGKRNAQFRQCLIDTALDGVEREYKVNLDRANLKFPKLDYKGLARPTVLRKLSKDATAEELEPHPLEHMYPKKPAANADQPKVLPMKTKVTPAPTFAVPKYSIKHSHDVDLAEYTDELDAKLQVTMPRALVVEIELPLLSSTADCQLDVTEKSVYLLSERQGAKYRLKLDLPYTVNDKAGNARFDTEHRRLCITLPVVRSTAREQRNLHDTVRVLTREDSGVELNSNGESPVEDEAEAEVEADAIVELQSHDQRDVSDAFPPTAVVSPRSFLKDNLHYKLPASFDCNILDNVIAFVLHVPNVQPDSVQTLQQARSLHLQFASMGSGYYPTHYAFLVQLPDGLEPQLQIDHIDVDAADENVVLRLYMNENCMLLPSYLAGPDSTDLKEYPVFGHFNNNNNNEKEYEGCSLASEKSLYINMDHNDLEHALEVSIMPQESTDPLDSIELLQQQQQQLQQLQQQKKLNKKQRKRNKKQRSLSESACEELKAAQEELQLQHEKQQQQQQLPSTPKDASPERLQNVSQPVDTLKLPQRKQRSYSECNESSSCVQRGILKRFSRYGPRPSISDSCSSIDDCSSTYSCSMDAPGMGFSQSFGGIPEERSGEGDVGLSESCKKTVRFNDHIMKQVFRLDSSILGQRKKNQKRRDCKLRAQQRRLSEGDSADYEEVEHGNGQQPPAHKTAANAQYFKQPNNNNGHDQDKNKKLSMHDSGLDLTNNNNHNNEEETKRNEADAKNAMMFEMDDDDEDEDEDM
What is the function of this protein?
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella.  Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
What are the official names of this protein?
Protein kintoun, Dynein assembly factor 2, axonemal homolog, PP1-interacting protein 20.
What is the protein family that this protein belongs to?
Belongs to the PIH1 family. Kintoun subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NORW_ECO8A
Sequence: MSNGIVIIGSGFAARQLVKNIRKQDATIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAEQFNLHLFPQTWVTDIDAEARVVKSQNNQWQYDKLVLATGASAFVPPVPGRELMLTLNSQQEYRACETQLRDARRVLIVGGGLIGSELAMDFCRAGKAVTLIDNAASILASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGILATLDRQRSIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNADIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTERQGMVARGVDDADQLRAFVVSEDRMKEAFGLLKTLPM
What is the function of this protein?
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase.  Reduces the rubredoxin moiety of NO reductase.
What are the official names of this protein?
Nitric oxide reductase FlRd-NAD(+) reductase, Flavorubredoxin reductase, FlRd-reductase, FlavoRb reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_ACTP2
Sequence: MQQKLFIVTGHVQSVGFRFFTLQEAGKIGIKGYVKNRPEGSVEVVAVGSDAQMAAFRNWLQKGPPTSVVCNLIEQSYQGSEQFEHFEIRR
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: RRF_BURM7
Sequence: MSVADIKKSVEQKMQRSIEAFKNDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANLTLVDARTIGVQPWEKTMVAKVEKAIREADLGLNPATSGDLIRVPMPPLTEERRRELTKVVKSEGETAKVAVRNLRRDANEQLKKLVKDKEISEDDERRASDDVQKLTDKHVAEIDKLVQAKDAEIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_BRUSI
Sequence: MAQAFQFELVSPERLLLSAQVTEVVIPGNEGYLTALAGHSPLMTTIMPGVVSVKLADGKTDSYVVFGGFADITPQGCTVLAESATHVDDIDPADIQHRIDHARKVLEDASSNEHRTKAEIFLHQLMTLQGAILPA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MED31_ASPTN
Sequence: MDPQPGDQAQQPPPPTLTHPRFTLELEFVSSLANPYYLSHLAVNYPNLLGINKSGDDNDTNDSGDPDAQAFAAYLAYLYSYWKTPEYAQFLTHPGATLRALRLLQEDTFRRDIIRPQVIEGLAGTGIENEQGGTEANNPGEAEGEQTKGTADQQDGSSKT
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 31, Mediator complex subunit 31.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 31 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: XYLA_RHILW
Sequence: MSTGFFGDIQKVKYEGPDSTNPLAFRYYQPDEIVMGKRMEDHLRFAVAYWHTFTWPGGDPFGGQTFLRPWFEDTMKAAKLKADVAFEFFSLLGSPYYCFHDADVRPEGKNFAENTKNLNEIVDYFAEKQASTGTKLLWGTANLFSNRRYMSGAATNPDPDVFAFAAATVKTCIDATQKLGGENYVLWGGREGYETLLNTDLKRELDQLGRFLNLVVEYKHKIGYTGTILIEPKPQEPTKHQYDYDVATVYGFLKKHGLENEVKLNIEQGHAILAGHSFEHELALANALGIFGSIDMNRNDYQSGWDTDQFPNNVPEMALAYYHVLAGGGFKTGGTNFDSKLRRQSLDPADLLIGHIGGMDCCARGLKAAARMIEDKALSQPLADRYAGWESAEAQKLFRGEYSLDEITNWVETKDVNPQPRSGKQELLENVVNRYV
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_VIBVY
Sequence: MTTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAQAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARVMSAIPLNGVCDDYNWADAIRELRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPVANPDAELYDKLSYTDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLITA
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_SYNWW
Sequence: MDYIQEYVKPVDPEVAEAIEKEEARQNNKLELIASENFVSRAVMAAQGSVMTNKYAEGLPGARYYGGCEYVDIVEELARDRVKEIFGAEHANVQPHSGAQANTAVYFAALQPGQTIMGMNLNHGGHLTHGSKVNISGKYFNIVDYGVNRDTERIDYEELREIALKARPQMIVAGASAYPRILDFKKFREIADEAGALLFVDMAHIAGLVAAGLHPSPVPYADFVSSTTHKTLRGPRGGFILCRQEWANKIDKAVFPGIQGGPLMHVIAAKAVCFKEALTPEFKAYQQDIVNNAAILAKALMEQGLRVVSGGTDNHLMLVDVRPKGLNGRDAEAILESINITVNKNAIPFDPEKPTVTSGIRVGTPAVTSRALKGDDMRELARAITLVLDKHDSEEVKEEARRIVKALCDKYPLYT
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_RHILW
Sequence: MSEAIFLTFPDGSVRSFPAGATGRDVAESISKSLAKSAVAIAIDGTVQDLSDTVADGKIEIITRKDGRALELIRHDAAHVMAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPDDLPKIEKKMKEIIARNAPFTKQIWSREKAKEVFAAKGENYKVELVDAIPAGQDLKIYNQGDWFDLCRGPHMASTGQVGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWADQADLDNYLHMLAEAEKRDHRKLGREMDLFHFQEEGPGVVFWHGKGWRIFQALVSYMRRRLAVDYEEVNAPQVLDTALWETSGHWGWYQENMFAVKSAHAMTHPEDKEADNRVFALKPMNCPGHVQIFKHGLKSYRELPIRLAEFGLVHRYEPSGALHGLMRVRGFTQDDAHIFCTDEQMAAECLKINDLILSVYEDFGFKEIVVKLSTRPEKRVGSDALWDRAEAVMTDVLKTIEAQSEGRIKTGILPGEGAFYGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDSNSEKTQPVMIHRAICGSMERFLGILIENFAGHLPLWVSPLQVVVATITSEADAYGLEVAEALREAGLNVETDFRNEKINYKVREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQDQVSMGLDAAVDSLALEATPPDVRRKAEAKKARAA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATE_CENSY
Sequence: MPPDPRLEAAVDKILDRTGEEILSGLGESRKEAAEALAGSAKTLEREYDRIVEEGRKEADKIHRKIVGSADLEARNKQILLLETAIDRVLEKVLASISAERGPGYPDMIKSLIGEATATLGTTQVVVRAGSRDKDVVQASLGGFPGAELAQEPIECLGGVKVSSKDGSMTLDNTIDARFDRMKPLIRKEIVSKFGIGI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: CELF4_PONAB
Sequence: MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPFGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY
What is the function of this protein?
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing.  Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.  Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition.  Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs.  Activates the splicing of MAPT/Tau exon 10.  Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity).
What are the official names of this protein?
CUGBP Elav-like family member 4, CELF-4, Bruno-like protein 4, CUG-BP- and ETR-3-like factor 4, RNA-binding protein BRUNOL-4.
What is the protein family that this protein belongs to?
Belongs to the CELF/BRUNOL family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RCF1_ASPCL
Sequence: MDQEPIPSSLEDNPQFKEETSLQKFRRRFKEEPLIPLGCAATSYALYRAYRSMKAGDSVEMNKMFRARIYAQFFTLIAVVAGGMYFKTERQQRREFEKMVEQRKAQEKRDAWLRELEVRDKEDKDWRERHAAMEAAAKEAGKRKSVPEQDAARSAIEPADEKSIGVLAAVRELLARQN
What is the function of this protein?
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
What are the official names of this protein?
Respiratory supercomplex factor 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RCF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: QUEF_STAAC
Sequence: MAHGRQQDELQDITLLGNQDNTYNFDYRPDVLESFDNKHQGRDYFVKFNCPEFTSLCPITGQPDFATIYISYIPNVKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPHYIEVWGKFTPRGGISIDPYTNYGRPNSKYEKMAEHRLMNHDLYPEKIDNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y900_METJA
Sequence: MVIIMSEAELKEAMKRNPHLRRYIENFKRTYMRIPDFMVSLSRELKELKYPNIIYPVGDPIFIHIFGTPETKTKYIVIEPTLETAEEKLKYKMILNKILELAPYEETPKSVEEFEEVLTRLFNACTKVTEAVGEEGFFQRIFRFADNKIKITPEERDKFLYILKRDLIGLGNLEPIGRDPYLEDIHVIGPKNCHVVHKIFGMLPTNITWEDEIELADYLKNLGERMGRPVSDANPIVDGTLPDGSRINIIYSTDVSPKGPSFTIRKFTDVPISVTQLISWGTFSTEVAAYLWLCLEYGMSIFICGETASGKTTTLNAILPFIKPNSKIFSCEDTPEVKPPHPVWQQLVTRERGPEESRVTLFDLLRAALRSRPNYIIVGEIRSVEAAVAFQAMQTGHPVLSTFHAANVRKMIQRLNGDPINVPLTFMDNLNVALFQLAVYQRGKVLRRVVSIEEIEGYYKEVDGVVTRAVFQWEPDKDRHVFTGRNNSYVLEEKIAKAAGYEDPRDIYNELELRARILEEMIAREIFDYYQVRDIIWAFYEKGLEGLPFPI
What are the official names of this protein?
Uncharacterized protein MJ0900.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
Protein: EFG_CHLSY
Sequence: MPRQIELDKVRNIGIIAHIDAGKTTTTERILFYTGRTYKIGEVHEGTATMDWMPQEQERGITITAAATTAPWRLDGVEYRINIIDTPGHVDFTVEVERSLRVLDGGVVVFDGVAGVEPQSETVWRQADKYNVPRICFVNKMDRVGASFERCVQMIKDRLGAKPAIVQLPIGVEDSFRGTIDLFKMKATVYYDDLGKDIREEEIPAELRPAAEQARNELIEMIAETDDELTLLYLEGQELTVEELKRGLRKATIERKLVPVLCGAALRNKGVQKLLDAVVEYLPSPLDRPAITGTLPGQVMGDEGVEVITRPVSDDAPFTALVFKIVADPYVGKLAYFRVYAGKITKGSYVLNSTRNQRERLGRILRMHANHREDIEEVYAGEIAAMVGPKNSYTGDTICDPDHPIVLESIRFPEPVIELAVEPKTKADQDKMSIALSRLAEEDPTFRVYTDPETGQTIIKGMGELHLEVILDRMRREYKVEANQGKPQVSYRETITIPVDQETRFVRQTGGKGQYGHVKIKFEPLPPGSGFEFVNAIVGGVIPKEYIPAVEQGLREAMQTGVIAGYPVVDVKATLYDGSYHEVDSSEMAFKIAASMCLKDAVRRGKPQLLEPIMKVETVTPEEFLGTVIGDFNSRRGRIEGMEARGNAQVVRAFVPLANMFGYMTDLRSATQGRATSSMEFDHYEPLPEALAKEIIEKRSAN
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_CRIGR
Sequence: MATLQECKVKVDGEPKLSKNELKRRLKAEKKLAEKEAKQKELIEKQLSQAAAAAATNHTADNGVGVEEETLDPNQYYKIRSQAIHQLKVSGEDPYPHKFHVDISLTQFIQEYSQLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFVRINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIVRAKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMLSGMVKSITGSYKITYHPDGPEGEAYEIDFTPPFRRISMVEELEKALGVKLPETSLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVTMFLTDSNNIKEVLLFPAMKPEDKKETAAATETLESTTAGPSV
What is the function of this protein?
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11706011).  When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages.  Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (By similarity).
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted. Note=Secretion is induced by TNF-alpha. Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E.