PharMolix/UniProtQA huggingface dataset:
Protein: SYT_FRATW
Sequence: MINIRFPDGSIREFEAGVNSLDVAKSISPSLAKATMAAYIDDQLKDAKDAINSNCELRLITVKDPEGLEILRHSCAHLLAHAVKELYPNTEVTIGPVVDNGFYYDFSFKESIGEADLPTIEKKMKELAKKSAPVSYRVVPKAEAIEFFKAQGENYKVEIIDSIADEQMKIYTQDNFSDLCRGPHIPNTSVLKAFKLTKLAGAYWRGNSDNEMLTRIYGTCWATKEDLEQYLNMLEEAEKRDHRKIGKVLDLFHFQEDSPGIAFWHDNGVRIWRQVEDYMRASNNKYGCSEIRTPLIADFSLWQKSGHASKYAENMFATKSENRDFAIRPMNCPTCVQVYNTKLHSYRDLPIRMAEFGIVHRNEPSGSLHGLLRVRSFTQDDGHIFCTPEQVEEEVILMVQQCFEVYKDFGFNDFAIKIALRPENRIGDDETWDKSEQMLKNALDANNVSYELLPGEGAFYGPKIEFHLKDAIGRSWQCGTIQLDFSMPQRLGATYIDKNGEKQVPVMLHRAIVGSLERFIGMLIEHYAGNLPLWLAPVQVAVMGISNNQDDYCKEVFIMLEKNGIRAKLDLRNEKIGFKIREHTLLRVPYLVILGKNEQEQKIITIRKHSGEDLGQMSVDDFCAFLDKQIQAKE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTG_KLEAE
Sequence: VDGEQLEAAHQALREAVADCQRAGKRTLVLGGGHETAFGHGAGVLDAFPGEKVGIINLDAHLDLRFADCASSGTPFRQLALECDAQQRGFHYTCIGVSRAANTQALWDEAARRQVAIVEDLEVLTAFETRVLPELERNIAQFDRLYLTIDLDVLPAREMPAVSAPAALGVPLGTLLRIVEPLCRSGKLQAVDLVEFNPLFDIDGQGARAAARVAWQIAHWWR
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase, Histidine utilization protein G.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: RLME_EHRCJ
Sequence: MDNKFSIFKKGQYVLDLGSFPGGWSQFAAQKVSHGNNNLVFSVDIQNMDAIPNVIFIKCDISNEIEILNDKFHNKKFDVILSDMAPKACGNKQVDHANIINLCEMSLDIVIKFARENGTFITKILQGEYEKEFYQSMKSNFKLVKYFKPKASRKDSSEIYLVGLGFKKDFQ
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JAPL1_RHIAP
Sequence: MQLPLSHLLACYILASSIPSWTTSTPIMPAINKETLYLVGHSRSLKLTNVACVISTYRGQKDGWVERNMNYAFSVGKPWRGQSSTIHVQWRPYAALMNARTSDIVRHDLQTKPQYVVRNYDDNSLVLSDVKDESSPCSLWVTRKYLDNIPETTNRTFYHQCPEPIYTTIDEKCFENK
What is the function of this protein?
Salivary tick protein that modulates host immune response.  This protein blocks dendritic cell (DC) differentiation from monocytes (PubMed:23825947).  In addition, it inhibits up-regulation of costimulatory molecules and pro-inflammatory cytokines in response to stimuli and promotes up-regulation of co-inhibitory molecules and the anti-inflammatory cytokine interleukin-10.  It has a pocket to accomodate cholesterol, which may have immune-modulatory roles, either directly or through interactions with the host gut microbiota (By similarity).
What are the official names of this protein?
Japanin-like-RA1.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
Protein: ATPA_PAEAT
Sequence: MAELTINADDVRNALNEFAASYEPGNAERVEVGRVTTASDGIARVEGLPSVMANELLRFEDGTLGLAQNLDVREIGVIILGDFTGIEEGQEVHRTGEILSVPVGDAFLGRVVDPLGQPIDDLGEIKAEATRALELQAPGVTERKSVHEPMQTGLKAIDAMIPIGRGQRQLIIGDRQTGKTAIAVDTIINQKANWASGDVTKQVRCVYVGVGQKASTIAAVRQTLEDHGALEYTTIVASPASDPAGFKYLAPYAGSAIGQHWMYGGKHVLVIFDDLSKQAEAYRAVSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDELGAGSMTGLPIVETKANDVSAYIPTNVISITDGQIFLQSDLFNANQRPAVDVGVSVSRVGGAAQVKSMKKVSGTLKLDLAQYRDMQAFAMFASDLDAASRQQLTRGARLMELLKQGQYSPFPVENQVVSIWAGTNGYLDDVPVEDISRFESEFLEHLTHKSSILTTLAQTNVLDDDTAAALKEAIVSFKKGFFGEGDNHLVGAGHEEHAAISGGDVDQEKIVKQKR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y3585_ENT38
Sequence: MAQIPAGADRPGKLSRKQTGDAWELKARRWLEGKGLRFIAANVHGRGGEIDLIMKDGQVIVFIEVRFRQSSRFGGAAASVTLAKQHKLLQTAHLWLARHNGSFDTVDCRFDVVAFTGNDIEWLKNAFGEDA
What are the official names of this protein?
UPF0102 protein Ent638_3585.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: ACPS_STAAW
Sequence: MIHGIGVDLIEIDRIKVLYSKQPKLVERILTKNEQHKFNNFTHEQRKIEFLAGRFATKEAFSKALGTGLGKHVAFNDIDCYNDELGKPKIDYEGFIVHVSISHTEHYAMSQVVLEKSAF
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR1_YEAST
Sequence: MSSSSSSSESSPNLSRSNSLANTMVSMKTEDHTGLYDHRQHPDSLPVRHQPPTLKNKEIAKSTKPSIPKEQKSATRYNSHVDVGSVPSRGRMDFEDEGQGMDETVAHHQLRASAILTSNARPSRLAHSMPHQRQLYVESNIHTPPKDVGVKRDYTMSSSTASSGNKSKLSASSSASPITKVRKSSLVSPVLEIPHESKSDTHSKLAKPKKRTYSTTSAHSSINPAVLLTKSTSQKSDADDDTLERKPVRMNTRASFDSDVSQASRDSQETEEDVCFPMPPQLHTRVNGIDFDELEEYAQFANAEKSQFLASLQVPNEQKYSNVSQDIGFTSSTSTSGSSAALKYTPRVSQTGEKSESTNETEIHEKKEDEHEKIKPSLHPGISFGKNKVEGEENENIPSNDPAYCSYQGTDFQIPNRFSFFCSESDETVHASDIPSLVSEGQTFYELFRGGEPTWWLDCSCPTDDEMRCIAKAFGIHPLTAEDIRMQETREKVELFKSYYFVCFHTFENDKESEDFLEPINVYIVVCRSGVLTFHFGPISHCANVRRRVRQLRDYVNVNSDWLCYALIDDITDSFAPVIQSIEYEADAIEDSVFMARDMDFAAMLQRIGESRRKTMTLMRLLSGKADVIKMFAKRCQDEANGIGPALTSQINIANLQARQDNASHIKNNSSTTVPNNYAPTTSQPRGDIALYLGDIQDHLLTMFQNLLAYEKIFSRSHTNYLAQLQVESFNSNNKVTEMLGKVTMIGTMLVPLNVITGLFGMNVKVPGENSSIAWWFGILGVLLLLAVLGWFLASYWIKRIDPPATLNEAAESGAKSVISSFLPKRNKRFNDRSKNINVRAGPSNKSVASLPSRYSRYD
What is the function of this protein?
Plasma membrane magnesium transporter.
What are the official names of this protein?
Magnesium transporter ALR1, Aluminum resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IKZF5_DANRE
Sequence: MGEEKPEPLDFVKDFQEYLSQQTQHVNMISGSVIGVKDSDDLQGELAQNGLEHPAVDMSLEDSSGMLVDGFERTYDGKLKCRYCNYATRGTARLIEHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRRHKLLPMKGARSALSHRKMLSVLQKRGNSLGYGRRLLINLSPPSMVLQKPSSEQHHLGDFTHDLPPHAHLHQEAYNGLGKDPQAIGGAIGSGSREDQDMALDNPLNQLSTLAGQLASIPSEAEGAPVSPGAESLPDEKPTFLVQQPVTAPAAVSVNTAQASSPITPEPRPAAHSGCSPGVGPCSERTSTPSGTNSQPGTPTPVQDPQMLHHCPHCHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACHFARGQHK
What is the function of this protein?
Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity).
What are the official names of this protein?
Zinc finger protein Pegasus, Ikaros family zinc finger protein 5.
What is the protein family that this protein belongs to?
Belongs to the Ikaros C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KA165_LEIHE
Sequence: GLIDVRCYDSRQCWIACKKVTGSTQGKCQNKQCRCY
What is the function of this protein?
Augments responses to direct muscle stimulation probably by blocking calcium-activated potassium channels.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 16.5, Lqh 15-1, Toxin 15-1, alpha-KTx 1.7.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 16 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL17_PROMH
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEVVAKLFTVLGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRADSETEAAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: EFTS2_PARTE
Sequence: MFRKIYTNISITLIKQLREASGSPINDCKKALESTDGNFEKAIQYLKERGLAQAEKKMGNQTKQGVIVAYTNNKVAALAEINCETDFVARTSEFLEFSTNFIKTIVNQEQDFSSSNIDSVLNDKRKQLVGKLQENIVIGNLNAFVATKNSVFGVYQHNCLKNTICGLGGSVVELITESELTDVKTQILREGANNLAVTYLGLKPRFLYQHEVSSDVVDQIRKEVEKEFGSKTAQQQNFIVKGKLQNYYSDNVFEHQEYFLNEDEPKTIKQYMAKELEEVIKDKVKIGRCLYLTI
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, mitochondrial 2, EF-Ts 2, EF-TsMt 2.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TAF4B_HUMAN
Sequence: MPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSPVGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGTVLIKSNSGPLMLVSPQQTVTRAETTSNITSRPAVPANPQTVKICTVPNSSSQLIKKVAVTPVKKLAQIGTTVVTTVPKPSSVQSVAVPTSVVTVTPGKPLNTVTTLKPSSLGASSTPSNEPNLKAENSAAVQINLSPTMLENVKKCKNFLAMLIKLACSGSQSPEMGQNVKKLVEQLLDAKIEAEEFTRKLYVELKSSPQPHLVPFLKKSVVALRQLLPNSQSFIQQCVQQTSSDMVIATCTTTVTTSPVVTTTVSSSQSEKSIIVSGATAPRTVSVQTLNPLAGPVGAKAGVVTLHSVGPTAATGGTTAGTGLLQTSKPLVTSVANTVTTVSLQPEKPVVSGTAVTLSLPAVTFGETSGAAICLPSVKPVVSSAGTTSDKPVIGTPVQIKLAQPGPVLSQPAGIPQAVQVKQLVVQQPSGGNEKQVTTISHSSTLTIQKCGQKTMPVNTIIPTSQFPPASILKQITLPGNKILSLQASPTQKNRIKENVTSCFRDEDDINDVTSMAGVNLNEENACILATNSELVGTLIQSCKDEPFLFIGALQKRILDIGKKHDITELNSDAVNLISQATQERLRGLLEKLTAIAQHRMTTYKASENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKELQQLELAQIQHRDANLTALAAIGPRKKRPLESGIEGLKDNLLASGTSSLTATKQLHRPRITRICLRDLIFCMEQEREMKYSRALYLALLK
What is the function of this protein?
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells.  TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.  TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit.  Involved in the activation of a subset of antiapoptotic genes including TNFAIP3.  May be involved in regulating folliculogenesis.  Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription.  Plays a role in spermiogenesis and oogenesis.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 4B, Transcription initiation factor TFIID 105 kDa subunit, TAF(II)105, TAFII-105, TAFII105.
What is the protein family that this protein belongs to?
Belongs to the TAF4 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
Protein: RNC_MANSM
Sequence: MNHLDRLQRQISYEFKDITLLKQALTHRSAATKHNERLEFLGDAILNYTIADALYHQFPKCNEGELSRMRATLVREPTLAILARQFKLGEYMALGHGELKSGGFRRESILADCVEAIIGAISLDSSLVSATQITLHWYEKLLREIKPGENQKDPKTRLQEYLQGHRLALPTYDVKDIKGEAHCQTFTIECHVPNLDRTFIGVGSSRRKAEQAAAEQILTALEIK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CM3G_CONAO
Sequence: ECCTHAHCSQGCRPCC
What are the official names of this protein?
Conotoxin ar3g, Conotoxin ar3h.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YCIC_ESCF3
Sequence: MSITAQSVYRDTGNFFRNQFMTILLVSLLCAFITVVIGHVFSPSEAQLASLDKVETLSDNAGLFEIVQNMSLEQKQVLVQASAASTFSGLIGNAILAGGMLLLIQLVSAGHRVSALRAIGASAPILPKLFILIFLTTLMVQIGIMFVVVPGILMAIVLALAPVMLVQDKMGVFASMRSSIRLTWANMRLIAPAVLSWLLAKTALLLLASRFAALTPEVGAILANTLSNLFSAVLLIYLFRLYMLIRQ
What are the official names of this protein?
UPF0259 membrane protein YciC.
What is the protein family that this protein belongs to?
Belongs to the UPF0259 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TM129_XENLA
Sequence: MESPAVTFTLAYVVFSVCFVFTPNEFHSAGITVQNLLSGWLGSEDVAFVHYHIRRSSATLLAHSLLPMGYFIGMCFAAPEKELYNVHKAADGWKVFVLMAVLLPIATSILAFYWSQKRWSNHPLAKTLAHHALPQSSWRAVASSINTEFRRIDKFATGAPSARVIVTDTWVMKVTTYKVDVAQQQDIHLTVTDSRQHELSPDSNTPVQFITIRVASINPRVKPFDIRLNSTEYGELREKLHAPIRNAANIVIHQTLGDMFLDTFRSLVEANHTYEISSNQELEPCIGCMQTNANIKLVKYCQEANEGECQQCYCRPMWCLTCMGKWFASRQDQQHPETWLSSQVPCPTCRAKFCIVDVCIVR
What is the function of this protein?
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2.
What are the official names of this protein?
E3 ubiquitin-protein ligase TM129, RING-type E3 ubiquitin transferase TM129.
What is the protein family that this protein belongs to?
Belongs to the TMEM129 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TSAD_STRP4
Sequence: MKDRYILAFETSCDETSVAVLKNDDELLSNVIASQIESHKRFGGVVPEVASRHHVEVITACIEEALAEAGITEEDVTAVAVTYGPGLVGALLVGLSAAKAFAWAHGLPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSEAGDYKIVGETRDDAVGEAYDKVGRVMGLTYPAGREIDELVHQGQDIYDFPRAMIKEDNLEFSFSGLKSAFINLHHNAEQKGESLSTEDLCASFQAAVMDILMAKTKKALEKYPVKTLVVAGGVAANKGLRERLAAEITDVKVIIPPLRLCGDNAGMIAYASVSEWNKENFAGWDLNAKPSLAFDTME
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLDE_TRIL1
Sequence: MDRKMVESLFQRASTLKCLVVGDLMLDEYLWGRTDRISPEAPVQVVDVLREDLRLGGAGNVANNLLALGCQVTVASVIGEDENGWALLKAFSRQGVDTAPIYQEPGRRTGRKTRVIAANQQIVRIDRESREPLSGQIEQQLINWLQQHITGFDVVLVSDYLKGVLTPSVLASVTSTASRRNIPVLVDPKGSDYSKYRGATCLTPNRKEAEAASGVPIQDGASLQQAADTIMSTVGLDNLLITRSEEGMSLFCGNGETVHIPTVAREVFDVTGAGDTVLALLACGLAGGLPLAESARLANVAAGIAVAKLGTSTVTPAEIIAAVSLEHRDSDSKIKNREVLSEIIAAERAKGRQVVFTNGCFDLLHAGHVKYLQAARRLGDLLILGLNSDASVRRLKGPKRPLIDEDERGHLMAALDCIDYVCLFEEDTPLELITALKPQILVKGGDYTPEGVVGKDLVESYGGRVELIPFVDGKSTTNIIEKVLERYTDEQ
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: DDL_METSB
Sequence: MSKHVAVLMGGLSAEREVSLRSGAACAKALEAEGFRVTTLDVDRDIAQKLAALRPDAALNALHGRYGEDGVIQGVLEMLAIPYTHSGVLASALAMQKDRAKDVLRAAGVPVAEGVTIGRFEAAKAHVMTPPYVVKPLGEGSSFGVIIVRADQTHPPQELTRDDWAYGDLVLVERFVAGRELTCAVIGDKAYGVTEIRAADGGWYDYDAKYKAGGSIHILPANLKEFVYQNVQELALVAHRALGCRGVSRTDFRYDDTPQGTGELVVLEVNSQPGMTETSLVPEIAAYAGISFGELVRWMVEDASCDR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHF19_HUMAN
Sequence: MENRALDPGTRDSYGATSHLPNKGALAKVKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADQPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLLPNENSASSELRKRGKSKPGLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLAAKAYMPLRAKRWAAELDGRCPSDSSAEGASVPERPDEGIDSHTFESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY
What is the function of this protein?
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:23104054, PubMed:31959557).  Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351).  Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal.  Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054).  Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832).
What are the official names of this protein?
PHD finger protein 19, Polycomb-like protein 3, hPCL3.
What is the protein family that this protein belongs to?
Belongs to the Polycomblike family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to chromatin as part of the PRC2 complex.
Protein: SCPA_STRSV
Sequence: MDIKLKDFEGPLDLLLHLVSKYQVDIYDVPITEVIEQYLAYVATLQAMKLEVTGEYMVMASQLMLIKSRKLLPKVADNAELEDDLEQDLLSQIEEYRRFKLLGEKMSLQHDDRALYYSKPKLELVYEDAELLHDKSTIDLFLAFSKVIAKKQEEFSKSHTTIVRDEYKIEDMMEVVRQRCAGKSRLALQEIFAETKDMNEVITLFLATLELVKVQEVQVIQEENFGNIYLVGRGNE
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: FUMC_STAAW
Sequence: MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQIDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCEIMLSESKKHILNLAIGGTAVGTGINAHPEFGDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD1_RHIEC
Sequence: MTEHNVRNFNINFGPQHPAAHGVLRLVLELDGEIVERVDPHIGLLHRGTEKLIETKTYLQAVPYFDRLDYVAPMNQEHAYALAVEKLLGIQIPIRGQLIRVLYSEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHAAYFRPGGVHQDLPEKLVQDIGDWCDPFLKALDDIDDLLTGNRIFKQRNVDIGVVSLEDCWAWGFSGVMVRGSGAAWDLRRAQPYECYSDLEFDIPIGKNGDNYDRYLIRMIEMRQSVRIMKQCVNRLLSDARTGPFSSIDGKVVPPKRGEMKRSMEALIHHFKLYTEGYHVPAGEVYTAVEAPKGEFGVYLVSDGSNKPYRCKIRAPGYAHLQAMDFMCRGHQLADVAAVLGSLDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 1, NADH dehydrogenase I subunit D 1, NDH-1 subunit D 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y492_STRA1
Sequence: MRLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENALIGVNDHTLVTENDGRRWVTREPAIVYFHKKYWFNIIAMIRETGVSYYCNLASPYILDPEALKYIDYDLDVKVFADGEKRLLDVDEYEQHKAQMNYPTDIDYILKENVKILVEWINENKGPFSSSYINIWYKRYLELKKR
What are the official names of this protein?
UPF0374 protein SAK_0492.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: UREF_SYNP2
Sequence: MQQLILWQLINSNFPLGAYNYSEGLEYLVESAGCSEVESFQDWLGLHLRYGSIRAEVSIVLRIVQAIASGDFNQLQYWNTWLNGTRETRELRQQSIQMGNSLLKLLGDLDENKRPQLGACREQIGKSCHYAIAFGIAIALWDIESHQAVLGYLHSWLSNLVSAGVKLIPLGQTQGQRIIYQLQPLIIETVETVVTQKEMDLYACTWGLSLASMNHETQYTRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_CYAP4
Sequence: MKKVLAIILGGGAGTRLYPLTKQRAKPAVPLAGKYRLIDIPVSNCINSEITHVYVLTQFNSASLNRHIARTYNFSGFSDGFVEVLAAQQTPENPDWFQGTADAVRQYLWLLSDWEVDYYLILSGDHLYRMDYRLFVNRHRDTNADITLSVLPVEEQVASSFGLLQVDHSGRVTAFSEKPQGEALTRMRVDTTDFGLTPAEAAHKPYLASMGIYVFNRQVLIDLLKQSPQSTDFGKEIIPMAATDHNVQTYLFNDYWEDIGTISSFYEANLALTRQPQPPFSFYDEKAPIYTRPRYLPPSKLLDCQVTESIIGEGCILKNCQIQHSVLGVRSRIESGCVIDNALLMGADFYQPFAERDHKIKNNSVPLGIGADTIVRRAIVDKNACIGRNVKIVNKDHVEEANRESEGFYIRNGIVVVLKNAVIPDNTVI
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.