PharMolix/UniProtQA huggingface dataset:
Protein: MEB2_ARATH
Sequence: MEKSNQPVHVTLSELKDGDKEIVDAEFLVDLLESYRFGKDNVPAREFRSKAAATAPAPVNTTEIELEEDNDGSQAQGNNSVSESTSSLFSDSDPIVLESTVSETGSNEESETGSNEENGNNWLESSSTNLPNVENKRQRNGEDCEIEEEEENNERSLSDSEEKSNLEKLLGTQENYELGNEDEEKNERSSSDSEEKSNLENLLATQENYELYCPSCSTCITRNVVLKKRKRGKHVNSSLDLKPDIPVVEPDEPSDIEEMESPVKVYVPETRIEDDQEDKEGTIFTCLVCDLKYFIRLGTKFLQLDYIRGKPVEKSVEEYIDVRKSINTTQSPPQIQPDGERFAIELLKSTVYGGLTETITSLGVVSSASASGSSTMNILALAVANLAGGLIVLAQNFQDLRNSSDQEKDRYEELLGRRTKSRIHILVAVMSYIFFGLIPPLVYAFSFYETGIKNYKLISVFLGSLVCVILLGSIKVYVRKPTNSCGSTKAYLKSAAYYTSIVVASCGISYVVGDIMGEYIEKLSLVGLDQISITSPCYGIKPEECRFTSF
What is the function of this protein?
May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity.  Not essential for the accumulation of ER body components, including PYK10.
What are the official names of this protein?
Membrane protein of ER body 2.
What is the protein family that this protein belongs to?
Belongs to the CCC1 family.
Protein: SYC_BURP1
Sequence: MESLRIYNTLARDKQDFVPRQPGEVRMYVCGITVYDYCHIGHARMVVVFDIVQRWLRARGYRVTYVRNITDIDDKIIRRAVENGETIQSLTRRFTDAMNADFDALGVERPDLEPRATEFIPQMLGMIEKLEANGYAYQAKDGDVNYSVRKFANYGRLSGKSLEDLRAGERVAANDAKEDPLDFVLWKRAKPQEPAGASWESKYGAGRPGWHIECSAMGCTLLGAHFDIHGGGQDLQFPHHENEIAQSEGATGQTFVNYWMHNGFVQVDSEKMSKSLGNFFTIREVLEKFDAEVVRFFIVRTHYRSPLNYSDVHLDDARASLTRLYTALKDATPDAQPLDWSEAHAQRFAAAMNDDFNTAVAVAVLFELATEVNRTREPALARQLRLLAGLLGLLGREPREFLQHAAGAARTGALEPHEIEARIAARVAAKQAKNYAEADRIRAELLEAGIALEDKPGGSTEWRRV
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLO_MICAN
Sequence: MADKLIRATAADGGIRVVGVITTRLTEEARQRHKLSNVATAALGRTMASALLLASSLKKPGSRVNIRIKGDGPLGGVLVDAGLDGTVRGYVDYPQVELLPNAQGKLDVGRAVGDKGYVRVLREEKGEGRNELQESIVEIVSGEVGEDIAYYLDQSEQIPSALQVGVFVGTTTGVTAAGGILLQVLSKEASRDEVLVARLESRLRKLTGFTPLLRAGKGLEDIFQELLGDMGLEIFPAVQMLRFDCDCSFERALGALKFLGVDELKDIIEKDKQAEAICEFCREVYNANERQLIELVESLQAESC
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSG2_YEAST
Sequence: MANRGEPDPKKSTESICSLTKPQLYSLYDDDVVRSEDNEIYEELKRSVSIDSTKYSRDQTIDSTFYLAHKVGGSLPRNTVSSNNLERILSASSIHENFPSRTRQTRQNILHYLQAVLILSLSGFAYHELSRNLHDNHLLHPDFASRPLLLGVKLCNWLSNGVLPNWLGYGVEGLLFGSVVPILDNIFQTEVVKSSVHHDSLTSVIRSINAMLGVTFGIRKIQWNSSLQAAGAWGLLNIILWLFFDGSISMLMSCICIGVGCCISCYKDIIDGSQFLYFMDFYFLGSLMFGKLGRYLYSH
What is the function of this protein?
Stabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation.  Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation.
What are the official names of this protein?
Protein NSG2, INSIG homolog 2.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CYOE_XANOM
Sequence: MAVRARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAAINQLLDAKIDAQMARTSWRPLVVGKVQPWQVLVFAGALIVISMTILVVWVNVITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVTGLPTSADWINASLLVLIIFIWTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLLPVTVGMSGVFYLGGAVVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS18_THEPX
Sequence: MTTANTTAKDNAATKKRGRKAKKRVCAFCTDNIDKIDYKDVARLRKYITERGKILPRRITGNCARHQRQLTKAIKRARQIALLPYTVE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MANA_LABPU
Sequence: LVSSGQLEFIDGGVQIDPFGHSAVQAYFEVNDNSLPVQDNVELFDYNVQERVNDFVAAALSQANITRVNALYSTPSIYTDAKYATNEYWPLKTDDFFPYADRFNSGPNTDSLADALAIAQHHDAVTGTEKLAIGYQEAEELVSSSLACVQDSDGLEIESQLLPQQKVSVPPLGFSTYTVLTAKYDETGQASGAYLFRPDGTWHGNAKLTVLDGPVLDEVHQQINPWIYQITRSVLVDRPLGGSSLQDGQIELYYRIDPLGEGAKWRRSFGQEIYSPLLLAFAEQDDQDEW
What is the function of this protein?
Liberates mannose from p-nitrophenyl-alpha-D-mannoside.
What are the official names of this protein?
Alpha-mannosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 38 family.
Protein: TRHO_BACC1
Sequence: MATTKPYRVLLYYMYTTIENPEEFAAEHLAFCNSLELKGRILVAKEGINGTCSGTVEQTEKYMEAMNNDPRFDGIVFKIDEADGHAFKKMHVRPRPELVTLRLEDDINPHEITGKYLEPKDFYEAMKQEDTVIIDARNDYEFDLGHFKGAIKPDIESFRELPDWIRENKEVLEGKKILTYCTGGIRCEKFSGWLVREGYEDVSQLHGGIVTYGKDPEVQGELWDGQCYVFDERIAVPVNQKEHVIVGKDYFTGEPCERYVNCANPECNKKILCSEENEAKYLRACSHECRVSPRNRYVIQHELTEEQVAAALEKIEAGK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: NR5A2_CHICK
Sequence: MLPKVETEALGLARSNGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMTQVIQAMPTDLTISSAIQNIHSASKGLPLNHTALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDGYQTSSPASIPHLILELQKCEPDEPQVQAKIMAYLQQEQANRSKHEKLNTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHVKEGSILLVTGQQVDYSVIASQAGATLNNLMSHAQELVAKLRSLQFDLREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTDKFGQLLLRLPEIRAISMQAEEYLYCKHLNGDVPCNNLLIEMLHAKRA
What is the function of this protein?
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis.  Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism (By similarity).  Activates the transcription of CYP2C38 (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 5 group A member 2, FTF/LRH-1, OR2.0.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PROA_RHOP5
Sequence: MTAPLKAVEGSVDLPALMLQLGRQARSAARVLAIAPTAQKNLALAAMERAIRVNAAAILAANAEDVAEVKASGASSAFIDRLTLTPARIAAMADGIKVIHDIADPVGAVTERWQRPNGMTIERVRVPLGVIGVIFESRPNVTADAGVLGLKSGNAVMLRGGSDSFRSCRAIHDCLVQGLREADLPEAAITLVPVRDRAAVGLMLSGLNGNVDVIVPRGGKSLVARVEAEARVPVFAHLEGVNHVYVDRGADLAMAKAIVLNAKMRRPGVCGAAETLLVDRAAAEADLAPLLSVLIESGCEVRGDAEMQRVDTRVKPVAEEDWSTEYGEPIIAAKVVDGLDGALLHIARYGSHHTEAIVTQDEAAAARFLNEVDAAIVLHNASTQFADGGEFGFGAEIGIATGKFHARGPVGAEQLTSFKYRVHGTGQTRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_RHIEC
Sequence: MIQTTFPDRALMAELVAKMLWEIKAVHFNAAQPYKLSSGMASPVYIDCRKLLSYPRIRSTVMDFAASTLLRDAGFEQFDCIAGGETAGIPFAALLADRLGLPMIYVRKQPKGHGRNAQIEGNMPEGSRVLVIEDLTTAGGSMFKFIDAVRAAGGIVDHGIALFFYDIFGQQRFTDGKVRLHHIATWRNVLAVARAQQLFDDKTLAEVEAFLDAPLAWSGRNGGVSELSL
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ENV_HV1OY
Sequence: MTARGTRKNYQRLWRWGTMLLGMLMICSAAENLWVTVYYGVPVWKEATTTLFCASDARAYATEVHNVWATHACVPTDPNPQEVVLGNVTENFDMWKNNMVEQMQEDIISLWDQSLKPCVKLTPLCVTLDCTDVNTTSSSLRNATNTTSSSWETMEKGELKNCSFNTTTSIRDKMQEQYALFYKLDVLPIDKNDTKFRLIHCNTSTITQACPKISFEPIPMHYCTPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSSNFTNNAKIIIVQLNKSVEINCTRPNNNTRNRISIGPGRAFHTTKQIIGDIRQAHCNLSRATWEKTLEQIATKLRKQFRNKTIAFDRSSGGDPEIVMHSFNCGGEFFYCNTSQLFNSTWNDTTRANSTEVTITLPCRIKQIVNMWQEVGKAMYAPPISGQIRCSSKITGLLLTRDGGKNTTNGIEIFRPAGGDMRDNWRSELYKYKVVKIEPLGVAPTKARRRVVQREKRAVGMLGAMFLGFLGAAGSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTTVPWNASWSNKSLNEIWDNMTWMQWEREIDNYTHLIYTLIEESQNQQEKNEQELLELDKWAGLWSWFSITNWLWYIRIFIIIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTRLPTQRGPDRPEGIEEEGGERDRDRSGRLVDGFLALIWDDLRSLCLFSYHRLRDLILIVARIVELLGRRGWEVLKYWWNLLQYWSQELKNSVISLLNATAIAVAEGTDRVIEIVQRAYRAFLNIPRRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: MURT_STAAC
Sequence: MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNADDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISSFDVAPFLYLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQTIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
What is the function of this protein?
The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide (PubMed:22303291).  The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue (By similarity).
What are the official names of this protein?
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurT subfamily.
Protein: Y1137_ARATH
Sequence: MGKIGIVFFASLLFLLIIFPSCAFAAITRASPLSIGQTLSSPNGTYELGFFSPNNSRNQYVGIWFKNITPRVVVWVANRDKPVTNNAANLTINSNGSLILVEREQNVVWSIGETFSSNELRAELLENGNLVLIDGVSERNLWESFEHLGDTMLLESSVMYDVPNNKKRVLSSWKNPTDPSPGEFVAELTTQVPPQGFIMRGSRPYWRGGPWARVRFTGIPEMDGSHVSKFDISQDVAAGTGSLTYSLERRNSNLSYTTLTSAGSLKIIWNNGSGWVTDLEAPVSSCDVYNTCGPFGLCIRSNPPKCECLKGFVPKSDEEWNKRNWTGGCMRRTNLSCDVNSSATAQANNGDIFDIVANVKPPDFYEYLSLINEEDCQQRCLGNCSCTAFSYIEQIGCLVWNRELVDVMQFVAGGETLSIRLASSELAGSNRVKIIVASIVSISVFMILVFASYWYWRYKAKQNDSNPIPLETSQDAWREQLKPQDVNFFDMQTILTITNNFSMENKLGQGGFGPVYKGNLQDGKEIAIKRLSSTSGQGLEEFMNEIILISKLQHRNLVRLLGCCIEGEEKLLIYEFMANKSLNTFIFDSTKKLELDWPKRFEIIQGIACGLLYLHRDSCLRVVHRDMKVSNILLDEEMNPKISDFGLARMFQGTQHQANTRRVVGTLGYMSPEYAWTGMFSEKSDIYAFGVLLLEIITGKRISSFTIGEEGKTLLEFAWDSWCESGGSDLLDQDISSSGSESEVARCVQIGLLCIQQQAGDRPNIAQVMSMLTTTMDLPKPKQPVFAMQVQESDSESKTMYSVNNITQTAIVGR
What are the official names of this protein?
G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HSLU_RALSO
Sequence: MPETMTPSEIVSELDKHIIGQQKAKKAVAVALRNRWRRQQVADPLRQEITPKNILMIGPTGVGKTEIARRLAKLADAPFIKIEATKFTEVGYVGRDVDTIVRDLAEMAVKQTRESEMKKVRAKAEDAAEDRLLDVLIPPPRDIGFAQPEEKDSNARQVFRKKLREGQLDDKEIELEVAAGMPGMDIMGPPGMEEMTEQIRSMFAGLGQGKKHRRKMKVHEAFKLLVEEEAGKLVNEEELKHKAIANVEQNGIVFLDEIDKITSRSEHGGGEVSRQGVQRDLLPLVEGTTVSTKYGMIKTDHILFIASGAFQLSKPSDLIPELQGRFPIRVELDSLSVDDFQAILTQTDASLTKQYQALMKTEDVELVFADDGIRRLAEIAFSVNEKVENIGARRLYTVMERLLEDLSFHAHKSSGETVTIDAAYVDSRLNELAGSEDLSRYVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_STAAS
Sequence: MAKKGKKYQEAASKVDRTQHYSVEEAIKLAKETSIANFDASVEVAFRLGIDTRKNDQQIRGAVVLPNGTGKSQSVLVFAKGDKIAEAEAAGADYVGEAEYVQKIQQGWFDFDVVVATPDMMGEVGKLGRVLGPKGLMPNPKTGTVTMDVKKAVEEIKAGKVEYRAEKAGIVHASIGKVSFTDEQLIENFNTLQDVLAKAKPSSAKGTYFKSVAVTTTMGPGVKIDTASFK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PSTP_MYCTO
Sequence: MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSASAPTGTTPAIPTSASPAAPASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
What is the function of this protein?
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling.  May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell.  Plays a role in establishing and maintaining infection.
What are the official names of this protein?
Serine/threonine protein phosphatase PstP, Mycobacterial Ser/Thr phosphatase, Mstp, PP2C-family Ser/Thr phosphatase.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: PAQR1_MOUSE
Sequence: MSSHKGSAGAQGNGAPSGNREADTVELAELGPLLEEKGKRAASSPAKAEEDQACPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDSLL
What is the function of this protein?
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672).  Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672).  ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672).  Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337).
What are the official names of this protein?
Adiponectin receptor protein 1, Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.
Protein: CPSF7_RAT
Sequence: MSEGVDLIDIYADEEFNQDSEFNNTDQIDLYDDVLTAASQPSDDRSSSTEPPPPVRQEPAPKPNNKTPAILYTYSGLRSRRAAVYVGSFSWWTTDQQLIQVIRSIGVYDVVELKFAENRANGQSKGYAEVVVASENSVHKLLELLPGKVLNGEKVDVRPATRQNLSQFEAQARKRIPPRAHSRDSSDSADGRATPSENLVPSSARVDKPPSVLPYFNRPPSALPLMGLPPPPIPPPPPLSSSFGVPPPPPGIHYQHLMPPPPRLPPHLAVPPPGAIPPALHLNPAFFPPPNATVGPPPDTYMKASTPYNHHGSRDSGPLPSTVSEAEFEEIMKRNRAISSSAISKAVSGASAGDYSDAIETLLTAIAVIKQSRVANDERCRVLISSLKDCLHGIEAKSYSVGASGSSSRKRHRSRERSPSRSRESSRRHRDLLHNEDRHDDYFQERNREHERHRDRERDRHH
What is the function of this protein?
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs.  CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals).  Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.  The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.  CPSF7 activates directly the mRNA 3'-processing machinery.  Binds to pA signals in RNA substrates.
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 7.
What is the protein family that this protein belongs to?
Belongs to the RRM CPSF6/7 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm).
Protein: Y4311_PSEA6
Sequence: MPSFDIVSEIKLEEVRNAVENANRELSTRFDFRGVEASFELKENIVTMSCDSDFQLKQMLDILRGTCVKRGVDTAAFEEKDVQHIGKIYKQAIAFKEGIEQPVAKKLIKMIKDAKIKVQASIQGDQVRVTGKKRDDLQQVMALAKSSDLEQPLQFTNFRD
What are the official names of this protein?
UPF0234 protein Patl_4311.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: THYX_THEP1
Sequence: MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPEQVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: Y2779_PECCP
Sequence: MATKPDSRISWLQLLQRGQHYMKTWPAEKQLAPVFPENRVARATRFGIRIMPPLAVFTLTWQIALGGQLGPAIATALFACSLPLQGLWWLGRRSVTPLPPTLAQWFHEIRHKLLESGQALAPLEEAPTYQSLADVLKRAFSQLDKTFLDDL
What are the official names of this protein?
UPF0208 membrane protein PC1_2779.
What is the protein family that this protein belongs to?
Belongs to the UPF0208 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCR5_CERCP
Sequence: MDYQVSSPTYDIDYNTSEPCQKINVKQIAARLLPLLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPRIIFTRSQREGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
What is the function of this protein?
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.  May play a role in the control of granulocytic lineage proliferation or differentiation.  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
What are the official names of this protein?
C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F16PA_AERS4
Sequence: MRNMITMGEFIVKKQADYPTATGELTSLLSSIRLAAKVVNREINKAGLADIIGSMGAENVQGEVQQKLDVYANERFKAALEARGEVCGIASEEEEDFVSFDSELSRHSKYVVLIDPLDGSSNIDVNVSVGTIFSIYRRLSAPGTGVTLEDFLQPGNRQVAAGYVVYGSSTMLVYTTGFGVNGFTYDPSIGCFCLSHENIRIPEEGKIYSINEGNYIKFPDGVKKYLKYCQERDEATHRPYTSRYIGSLVSDFHRNLLKGGIYIYPSGTNSPNGKLRLLYECNPMAFLVEQAGGKASDGFGRIMDIQPTALHQRTPYFVGSTKMVERAEAFMREFSAHEDPANQG
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.