PharMolix/UniProtQA huggingface dataset:
Protein: SNAI1_MOUSE
Sequence: MPRSFLVRKPSDPRRKPNYSELQDACVEFTFQQPYDQAHLLAAIPPPEVLNPAASLPTLIWDSLLVPQVRPVAWATLPLRESPKAVELTSLSDEDSGKSSQPPSPPSPAPSSFSSTSASSLEAEAFIAFPGLGQLPKQLARLSVAKDPQSRKIFNCKYCNKEYLSLGALKMHIRSHTLPCVCTTCGKAFSRPWLLQGHVRTHTGEKPFSCSHCNRAFADRSNLRAHLQTHSDVKRYQCQACARTFSRMSLLHKHQESGCSGGPR
What is the function of this protein?
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration.  Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription.  Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration.  Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription.  The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (By similarity).  During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292).  SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292).  Associates with EGR1 and SP1 to mediate 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3'.  In addition, may also activate the CDKN2B promoter by itself.
What are the official names of this protein?
Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
Protein: SYNCI_HUMAN
Sequence: MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSMEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMETQSQGAV
What is the function of this protein?
Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior.  May facilitate lateral force transmission during skeletal muscle contraction.  Does not form homofilaments nor heterofilaments with other IF proteins.
What are the official names of this protein?
Syncoilin, Syncoilin intermediate filament 1, Syncoilin-1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity).
Protein: PSBE_PEA
Sequence: MSGSTGERSFADIITSIRYWIIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTETRQGIPLITGRFDSLEQLDEFSRSF
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HXA5_HUMAN
Sequence: MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSGSGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAPSPGSDSHHGGKNSLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Also binds to its own promoter.  Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
What are the official names of this protein?
Homeobox protein Hox-A5, Homeobox protein Hox-1C.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIN7C_PONAB
Sequence: MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQT
What is the function of this protein?
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.  Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains.  The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).  This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.  Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin.  Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells (By similarity).
What are the official names of this protein?
Protein lin-7 homolog C, Lin-7C.
What is the protein family that this protein belongs to?
Belongs to the lin-7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction. Note=Mainly basolateral in renal epithelial cells.
Protein: PSD_MYCPA
Sequence: MARRPRTIGPSAADPGFSPQHALELVRSAIPPVHPAGRPFVGAGLALALAGRRHRWLRRAGLLAAGACAGFFRHPPRVPPTRPGAIVAPADGEICVIDVATPPAELSMGDVALPRVSIFLSLLDAHVQRAPVSGEVIDVQHRPGRFGSADLAAASTENERTSLRIRTPGGAEVVAVQVAGLLARRIICDAHVGDKLSIGDTYGLIRFGSRLDTYLPAGAQPLVTVGQRAIAGETVLAELP
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: BDBD_BACAN
Sequence: MKSSNKLMALGIVFSIAVLIVIGTIVYSIINDKKDKGNEMFAYSTQQSLGKDDAPVKVVEFGDFKCPACRTWDVTVLPRLKEEYIDKGKVQLYFINFPFIGKDSDLGAAAGEAIYKQDQDSFWIFYDEIYQSQKKDTEEWITEELLLNIVKEKLPKIDVEQFKKDLHSKEIKEKVRKDSDRAQKLKVQGAPSVYVNGNLANPDFDSLKKAIDKELKK
What is the function of this protein?
May be required for disulfide bond formation in some proteins.
What are the official names of this protein?
Probable disulfide bond formation protein D, Disulfide oxidoreductase D, Thiol-disulfide oxidoreductase D.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbA subfamily.
Protein: MNMA_SHIB3
Sequence: MSETAKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWNNVFELFLAEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRADVDGKSRLLRGLDSNKDQSYFLYTLSHEQIAQSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFREFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKEGTEEPWYVVDKDVENNILVVAQGHEHPRLMSVGLIAQQLHWVDREPFTGTMRCTVKTRYRQTDIPCTVKALDDDRIEVIFDEPVAAVTPGQSAVFYNGEVCLGGGIIEQRLPLPV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJX1_SCHPO
Sequence: MPHEKQDRDAEEIEDEGKNIILGIVSQLRPNMDLSKVTFPTFVLEPKSMLERITNFMSHPDLLLNVQKTADPEMRFLDVVRFYMSGWHIRPRGVKKPLNPILGETFTGFWKFPPSNSKDPNLQKLHGIAVYAAEQVCHHPPISAYFYLCPEYKVRIDGVVKPRSRFLGNSAASIMEGIASIKLQDLDEEYLITQPNVYARGILFGKMRLELGDHVTVRCPKTDLQADIEFKVKGFISGTYNSIAGKVKRVSTGEVLYKISGKWDSEMSVESVKTGETRPLLDVSKHDVYLVSARPLEEQGERESQRLWYKTCQAVIARDQTTATETKSAIEDRQREEAKQREIENVQWKPKYFKMIAPEEYILNFDIPNGKSDLEVLCALDEFIPIFSEVDRIAFHKFLSENTKPEDSSIHKHSRDASGDSTKGFAEHMPAPARRRRPQSTASFVTYRSDNGSVDEYHDAQLPDPNTLSKLHEEQDPAL
What are the official names of this protein?
Oxysterol-binding protein homolog C23B6.01c.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSB28_PROM1
Sequence: MTKINENVAIQFVKGENEKDQPEIRLFRNLDGKNGKAVYKFYKPTTITLTNYKSVQRMFLIDSEGVLSTKKIDLSISEDHVKEVKSTYSWNSEEAFERFMRFASRYANSLSKN
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RIR1_PLAFG
Sequence: MYVLNRKGEEEDISFDQILKRIQRLSYGLHKLGEYPACVTQGVINGMYSSIKTCELDELAAQTCAYMATTHPDFSILAARITTDNLHKNTSDDVAEVAEALYTYKDGRGRPASLISKEVYDFILLHKVRLNKEIDYTTHFNYDYFGFKTLERSYLLRINNKIIERPQHLLMRVSIGIHIDDIDKALETYHLMSQKYFTHATPTLFNSGTPRPQMSSCFLLSMKADSIEGIFETLKQCALISKTAGGIGVAVQDIRGQNSYIRGTNGISNGLVPMLRVFNDTARYVDQGGGKRKGSYAVYIEPWHSDIFEFLDLRKNHGKEELRARDLFYAVWVPDLFMKRVKENKNWTLMCPNECPGLSETWGEEFEKLYTKYEEENMGKKTVLAQDLWFAILQSQIETGVPIYLYKDSCNAKPIKNLGTIKCSNLCCEIIEYTSPDEVAVCNLASIALCKFVDLEKKEFNFKKLYEITKIITRNLDKIIERNYYPVKEAKTSNTRHRPIGIGVQGLADTFMLLRYLYESDAAKELNKRIYETMYYAALEMSVDWLQSGPYESYQGSPGSQGILQFDMWNAKVDNKYWDWDELKLKIAKTGLRNLLLLAPMPTASTSQILGNNESFEPYTSNIYYRRVLSGEFFVVNPHLLKDLFDRGLWDEDMKQQLIAHNGSIQYISEIPDDLKELYKTVWEIKQKNIIDMAADRGYFIDQSQSLNIYIQKPTFAKLSSMHFYGWEKGLKTGAYYLRTQAATDAIKFTVDTHVAKNAVKLKNADGVQITREVSRETIQLNQRYSKCVSFKSNNDEQCLMCSG
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, Ribonucleotide reductase R1 subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: VNPA_PSETE
Sequence: SGSKIGNGCFGLPLDRISNTSGMGCRNPIQNRPKSTPGGS
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity (By similarity).  Recombinant PtNP-a demonstrates a dose-dependent stimulation of cGMP production via the natriuretic peptide receptor-A (NPR1).  It also inhibits the angiotensin converting enzyme (ACE).
What are the official names of this protein?
Natriuretic peptide PtNP-a.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_STRZP
Sequence: MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIKQHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: COPZ2_ORYSJ
Sequence: MGEFSKESCPSVKNILLLDSEGKRVAVKYFSDDWSSNASKLAFEKSVFTKTLKTNARSEAEITLFDGYIVVYKFVQDLHFFVTAGDDENELIIANVLQGFSDSVGLLLRGDVEKRTALENLDLILLCIDEIVDGGIILETDANTIAGKVATNAVDGSAPFSEQTISQALATAREHLARSLLK
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).  The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
What are the official names of this protein?
Coatomer subunit zeta-2, Non-clathrin coat protein zeta2-COP, Zeta-2-coat protein, Zeta-COP 2.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: RSMC_HAEIE
Sequence: MISLESQVLERHLSFFDGKSVLFAGGISDNFPQTLASKCPSIQIWSCHFDYARTQSAVNFSVEFQGQADLIVYYWTKNKQEVNFQLLQLLAQAPIGQEILIIGENRCGVRSVEKTLAPYGEIAKIDSARRCGLYHFSLQNKPHFELKNFWKTYQHSTLENLTIYSLPGVFSAAELDTGTELLLSTIDNKIKGKVLDLGCGAGVIGSMIKKRVPNAQITMTDIHAMALESARKTLSENQLQGKVYASDVFSDIEGKFDLIISNPPFHDGIDTAYRAVTELITQAKWHLNQYGELRIVANAFLPYPELLRQHFNDYQVLAQTGKFKVYSVKN
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_MARMM
Sequence: MTAIPTISVDAMGGDLGPAAVVEGIGHALKRWPDRKATYLLHGDEALLAPLLARHPKVAAVCELRHTETLVQMTDKPSEAVRRARGSSMWNAIQSVKSGEAGAIVSSGNTGALMAIGKVILRMKKGVHRPAISANWPTPKGHTVVLDVGANVQCNATQLVEFAIMGEAYHRAVFGGEAPSVGLLNVGQEELKGNDTVREADQLIRKANLDIAYQGFIEGNDISAGGIDVVVTDGFTGNIALKTAEGTARLVAGWVRDALTSSLLAKLAAGLLSLGALERLRQRMDPRYINGGVLLGLKGIVVKSHGGADGEGFASALGLAYVMAQSDFMAQIRANLDKFASFEEQEVAAAS
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: AGFG1_BOVIN
Sequence: MAASAKRKQEEKHLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSSAIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKSLLGDSAPALHLNKGTPSQSPVVGRSQAQQQEKKQFDLLSDLGSDIFAAPAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSSFQPQTTGGSAGSVNANFAHFDNFPKSSSADFGTFNTSQSHQTASAVSKVSANKAGLQTTDKYAALANLDNIFSAGQGGDQGSGFGTTGKAPVGSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVGASAQTQPASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPAGFGTPAPYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGAGFAAFGQTKPVVTPFGQVGAAGVSSNPFMTGAPTGQFPTGSSSTNPFL
What is the function of this protein?
Required for vesicle docking or fusion during acrosome biogenesis.  May play a role in RNA trafficking or localization (By similarity).
What are the official names of this protein?
Arf-GAP domain and FG repeat-containing protein 1, HIV-1 Rev-binding protein homolog, Nucleoporin-like protein RIP.
What are the subcellular locations of this protein?
Nucleus. Cytoplasmic vesicle.
Protein: DEP3_FUSLA
Sequence: MSEQSTLAGPYTEKPGVESQNPTGDGKASFDETSPRDIHGWRWAIAYAAMLSTTFLFALDNTIVANIQPSIINDFGHLELISWIGTGFALGTMFILLWGKIYGVFNIKWVYIFNILLFEVGSAVCGAAPNIQALIIGRVIAGIGGSGMYSGTLTYVSVLSNQKEKPAYLAGSTVVWGVGSVVGPVVGGAFAASSATWRWGFYINLPIGAVFAPAYMILFPNWDPNPTLTLAEKFRLVDWINAVIFLAGSACLTVALTFGGVVYSFNSGTIIALWTVTGVLLVAFIVLLKLHPLVSKENRLYPLHFFKQMTLINMQLQVFLASGIILAMTYYVPLYFQFIKGDGALQAGVRLLPLIMFMVAFSMVNGFLMPKYGLIPIWYIVGSALTLIGSALMYTIDENTSNGNVYGYNILVGAGAGCYIVAGFAIVQSLVPTHEIANAVGAMTISQDLGMVLFLAICGSLFHNVAVDKVGKALPSASETEIGNLIAGTSSSAFQALSEADKDLVIPEIASAMKSIWAFFMAAAALSFVCSWPLFKTKLGGKKVEASVVV
What is the function of this protein?
Efflux pump; part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099, PubMed:28460114).  Is presumed either to be responsible for exporting depudecin, to provide self-protection, or both (PubMed:19737099).
What are the official names of this protein?
Efflux pump DEP3, Depudecin biosynthesis cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS9_NAEFO
Sequence: MVQNRCYRVHSKVSLPPRRPFEKERMDRELKMCGKYGLKNKQEIWRLQYYLARARKTARHLLTLPEDDMKRQFEGAALLRRMTRLGLLDESKQQLDYILSLKTEDLLERRLQTVVQKLGLSKSIHHARQLIFQRHIRVGKQTVNVPSFIVRVDSEKHINMSPFSALVQGGKPGRMTRKKLKSQKSE
What are the official names of this protein?
40S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: GLSA_RHIL3
Sequence: MADLQATLDSIYADIQPRIGEGKVADYIPELAKVDPQQFGMAIVTVDGKVYRVGNADTAFSIQSISKVFMLTLALGKVGEGLWKRVGREPSGSAFNSIVQLEHESGIPRNPFINAGAIAVSDVVMAGHAPREAIGELLRFVRYLADDESITIDDKVARSETQTGYRNFALANFMRAYRNLDHPVDHVLGVYFHQCALSMSCEQLARAGLFLAARGSNPTTGHSVVSPKRARRINALMLTCGHYDGSGDFAYHVGLPGKSGVGGGIFAVAPGIASIAVWSPGLNKVGNSQLGAAALEMLAARTGWSVFGD
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: Y900_STAAT
Sequence: MNPIVEFCLSNMAKGGDYVFNQLENDPDVDVLEYGCLTHCGICSAGLYALVNGDIVEGDSPEELLQNIYAHIKETWIF
What are the official names of this protein?
UPF0349 protein USA300HOU_0900.
What is the protein family that this protein belongs to?
Belongs to the UPF0349 family.
Protein: CMOA_CAMC5
Sequence: MRDEIFKEPIKKQFEFDDFVVSVFDDMIGRSVPFYDVSGKLVSEILAKILPAKAHVIDLGCSTATSLLLLNQLRDDLVLEGVDSSSAMIENARKKAKAYGAKIKFSVGDVLESQICQMDAVMMNYTLQFIRPPKRAQLVKSIYDGLNEGGVFVFSEKIIYEDKKFAKNMIEIYENYKEKQGYSRYEIAQKREALENVLIPYTEEENRTLALGAGFKRVESVFKWGNFMTFLAFK
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: CLPX_RUEST
Sequence: MATNSSGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREETKASGMKATDGVPTPKDICEVLDDYVIGQATAKRVLSVAVHNHYKRLNHAQKAGNDIELSKSNILLIGPTGCGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIILKLLQASEYNVERAQRGIVYIDEVDKITRKSENPSITRDVSGEGVQQALLKLMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLDKIIKQRGKGSAMGFGADVREESDAGVGETFRDLEPEDLLKFGLIPEFVGRLPVLATLEDLDEDALITILTKPKNALVKQYQRLFELEDTELDFTDEALSAIAKKAIERKTGARGLRSILEDILLDTMFELPGMESVTKVVVNEEAVCSEAQPLMIHADEKESATAG
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: CTR2_YEAST
Sequence: MDDKKTWSTVTLRTFNQLVTSSLIGYSKKMDSMNHKMEGNAGHDHSDMHMGDGDDTCSMNMLFSWSYKNTCVVFEWWHIKTLPGLILSCLAIFGLAYLYEYLKYCVHKRQLSQRVLLPNRSLTKINQADKVSNSILYGLQVGFSFMLMLVFMTYNGWLMLAVVCGAIWGNYSWCTSYSPEIDDSSLACH
What is the function of this protein?
Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm.
What are the official names of this protein?
Copper transport protein CTR2, Copper transporter 2.
What is the protein family that this protein belongs to?
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: FOLD1_GEOSL
Sequence: MNLLDGKKCAESLVAEIARKVAGYTESGLRTPHMTIILVGEHAPSESYVKSKIATSGLAGFESTLLRFPETIRESELLAKIKEVNEDPTTDGLIVQLPLPKHINQQHVINAIAPEKDIDGFHPANFGRMTLGQKAFRPATAYGICKLLQFYEVPVKAKHCVVIGRSNIVGKPISIMLSNDFDIGNATVTLTHIETPRELLLDETRRADIVIVAVGIPGFVTADMVKDGVVLIDVGINRLESGKIVGDVDFENVAQKCSWITPVPGGVGRMTVAALMINTLMAYQNNFNLA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 1.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: HIS5_XYLFA
Sequence: MTEVALIDAGGANLGSVRYALQRLGVEPRLVCDARGLEGAARVILPGVGSAPEAMARLNNQGLIEPLLRLQVPLIGICLGMQLLFEHSEEGDVPCLALLPGRVRRLTPAPSIRVPHMGWNRLLPLRASPLLAEVPEGASAYFVHSYAVPLTTAAVAACDHGGMFTAIVQQGVRCGAQFHPERSAETGARILRNFLEMDAA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.