PharMolix/UniProtQA huggingface dataset:
Protein: MNME_KLEP7
Sequence: MSHNDTIVAQATPPGRGGVGILRISGLKARDVAQAVLGKLPKPRYADYLPFNDVDGTPLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTLPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNEVMADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLRDANDEVERIGIERAWQEIAQADRVLFMVDGTTTSAVDPAEIWPDFIERLPAKLPITVVRNKADVTGEALGISEVNGHSLIRLSARTGDGVEVLRNHLKQSMGFDTNMEGGFLARRRHLQALEEAANHLQQGKAQLLGAWAGELLAEELRLAQQALSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNB_SALPK
Sequence: MLDFLPFSRPAMGAEELAAVKTVLDSGWITTGPKNQELEAAFCRLTGNQYAVAVSSATAGMHIALMALGIGEGDEVITPSMTWVSTLNMIVLLGANPVMVDVDRDTLMVTPEHIEAAITPQTKAIIPVHYAGAPADLDAIYALGERYGIPVIEDAAHATGTSYKGRHIGARGTAIFSFHAIKNITCAEGGIVVTDNPQFADKLRSLKFHGLGVDAWDRQSGGRAPQAEVLAPGYKYNLPDLNAAIALAQLQKLDALNARRAAIAAQYHQAMADLPFQPLSLPSWEHIHAWHLFIIRVDEARCGITRDALMASLKTKGIGTGLHFRAAHTQKYYRERFPTLTLPDTEWNSERICSLPLFPDMTESDFDRVITALHQIAGQ
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: SRPRA_DICDI
Sequence: MLDSFTILTKGGIVLWSKEFAKIKGSPINSLIKKVLLEERSAETSFQIDSYSLKWTFSNEFDLIFVVVYQKIFTLLYIEELLTTVKKRFIKMYKDLLLKLKESSDFIIVDKFQEFNFEVILEDVENRSKLQQTSNSAPKKYEDTDKGKLVKDQKNERAIKEGRVEKVKRKEQEKKEKAERRKQNKANNINDISSDDDSDDSDSSSGSDSEENSNGATKNQQTDVARIENSGYKKKVKDTPDKQASSSTGKKARTWEDGKLSKKELEALNRSDNSNGTEIVREKIQKFNIDMDVSSSDDDDEEEAKPVSGFMKYFNVLTGNRVIDKQDLEPILADFKLHLTKKNVAPDVADKIVQSIGTGLEGKKLATFQGVTSVVKQQMEDTITRILTPKRNIDILREVQAVKGKRPYSIVFSGVNGVGKSTNLAKVCYWLTANGYKCMLAACDTFRSGAIEQLKTHADRLNVHLFERGYSKDAASVAQDAIAFAKDTGYDVVLIDTTGRMQNNEPLMKALSKLVNQNNVDLVLFVGEALVGNDGVDQLTKFDKSLSLLANTTQTHIRTIDGIILTKFDTIDDKVGAAISMVYSTGHPILFLGTGQNYTDLKRMNIKSVVKSLLH
What is the function of this protein?
Component of the SRP (signal recognition particle) receptor (SR) (By similarity).  Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).  Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit srp54 (By similarity).  SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
What are the official names of this protein?
Signal recognition particle receptor subunit alpha, SR-alpha, Signal recognition particle receptor, Docking protein alpha, DP-alpha.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Thought to be anchored in the membrane through an interaction with srprb, which contains a bona fide transmembrane domain.
Protein: NUOI_BARQU
Sequence: MSGLIQAAKSLLLLEFVSAFFLAMRQFFSPKPTINYPYEKGVVSQRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAGPRGNDGTRRTVRYDIDMVKCIYCGFCQEACPVEAIVEGPNFEFATEMREELYYDKEKLLMNGDRWEREIARNILIDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PBER1_ARATH
Sequence: MTSKSKILFIGGTGYIGKYIVEASARSGHPTLVLVRNSTLTSPSRSSTIENFKNLGVQFLLGDLDDHTSLVNSIKQADVVISTVGHSLLGHQYKIISAIKEAGNVKRFFPSEFGNDVDRVFTVEPAKSAYATKAKIRRTIEAEGIPYTYVSCNFFAGYFLPTLAQPGATSAPRDKVIVLGDGNPKAVFNKEEDIGTYTINAVDDPRTLNKILYIRPPMNTYSFNDLVSLWENKIGKTLERIYVPEEQLLKQIIESSPPLNVMLSLCHCVFVKGGHTSFEIEPSFGVEASELYPDVKYTTVDEILNQYV
What is the function of this protein?
Oxidoreductase involved in lignan biosynthesis.  Catalyzes the NADPH-dependent reduction of phenylcoumaran benzylic ethers.  Converts dehydrodiconiferyl alcohol (DDC) to isodihydrodehydrodiconiferyl alcohol (IDDDC), and dihydrodehydrodiconiferyl alcohol (DDDC) to tetrahydrodehydrodiconiferyl alcohol (TDDC).  Plays an important role in the biosynthesis of secondary metabolites.  In addition to the 8-5'-linked neolignan DDC, can reduce the 8-8'-linked lignans, pinoresinol, and lariciresinol, but with lower activities.
What are the official names of this protein?
Phenylcoumaran benzylic ether reductase 1, AtPCBER1.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: SYDND_DEIRA
Sequence: MTSPLKRTLTRELPQHEGQTVKLQGFVHARRDLGGVQFLVLRDVTGVTQCVGSGLTLPLAESSVEVVGKVKAHPKAPGGFEVQVEDFRVISAATEATPVEIPKMEWNVNPETMLDYRVVTVRGLKERAALKVQAELVDAFRAHLRGEGFTEISTPKIVSAGAEGGANLFPIDYFGHPAYLAQSPQLYKQIMVGVFERVFEVAAVYRAEEHATSRHLNEYLSLDVEMGFIEDEEDVMGLENRLLASIMERLRATSQAEFELLGATIPDVPAHIPRITLMDARQLVTEKYGHPVGGKDLDPEAERLLSQHFAETEGSDFVFVTKYPRAARPFYAHPELNEDGSVNGEVTRGFDLLFRGIEITSGGQRIHDYGMLMDSIAAYKLKPESLEGYTEVFKYGMPPHGGFAIGAERLTAKLLGIANVRYARAFPRDRHRLTP
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).  Is slightly more efficient at aminoacylating tRNA(Asn) over tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase 2, AspRS2, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALLB_ECOLI
Sequence: MSFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHTHISEPGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELGQPVLVHCENALICDELGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHVCHVSSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEIDCLVSDHSPCPPEMKAGNIMKAWGGIAGLQSCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQKGRIAPGKDADFVFIQPNSSYVLTNDDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ
What is the function of this protein?
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
What are the official names of this protein?
Allantoinase, Allantoin-utilizing enzyme.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
Protein: MKS1_RAT
Sequence: MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFKPPQAASGHRPDEEEEEEVIIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEVLKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSAGEAPSFLVERMANVRRRRQDRRGVEGSKLKSRIITWEPSEDFIRNSHAINTPLQTMYIMADLGPYGKLGYKIHEHVLCVLKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMIAPGALRLFVNGEVVSARGYEHDNLYVHFFVELPATNWSSPSFQQLSGVTQTCVTRSLGMDKVAYFSFPFTFEAFFLHEDESDESLPEWPVLYCKVLSLDFWQRYRVEGYGAVVLPVTPGSHTLTASTWRPMELGLVAELRRFFIGGSLELEDPSYVRIPGTFKGERLSRFGFRTETTGTVTFRLHCLQQSRAFMESNSLRKQMRSVLDRLEGFSQQSSTHNVLEAFRRARRRMQEARESLPQDLVSPTGTLA
What is the function of this protein?
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).  Involved in centrosome migration to the apical cell surface during early ciliogenesis.  Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication.  Required for cell branching morphology.
What are the official names of this protein?
Tectonic-like complex member MKS1, Meckel syndrome type 1 protein homolog.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Protein: U71E1_STERE
Sequence: MSTSELVFIPSPGAGHLPPTVELAKLLLHRDQRLSVTIIVMNLWLGPKHNTEARPCVPSLRFVDIPCDESTMALISPNTFISAFVEHHKPRVRDIVRGIIESDSVRLAGFVLDMFCMPMSDVANEFGVPSYNYFTSGAATLGLMFHLQWKRDHEGYDATELKNSDTELSVPSYVNPVPAKVLPEVVLDKEGGSKMFLDLAERIRESKGIIVNSCQAIERHALEYLSSNNNGIPPVFPVGPILNLENKKDDAKTDEIMRWLNEQPESSVVFLCFGSMGSFNEKQVKEIAVAIERSGHRFLWSLRRPTPKEKIEFPKEYENLEEVLPEGFLKRTSSIGKVIGWAPQMAVLSHPSVGGFVSHCGWNSTLESMWCGVPMAAWPLYAEQTLNAFLLVVELGLAAEIRMDYRTDTKAGYDGGMEVTVEEIEDGIRKLMSDGEIRNKVKDVKEKSRAAVVEGGSSYASIGKFIEHVSNVTI
What is the function of this protein?
May glycosylate diterpenes or flavonols in leaves.
What are the official names of this protein?
UDP-glycosyltransferase 71E1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: RNC_COLP3
Sequence: MKINPHNLARLTKKLGYEFNEPLLLVQALTHRSAKGAHNERLEFLGDSILGFVIAEALYDKFPKHDEGDLTRMRSSLVKGVTLAEVARDFNLGECLILGPGELKSGGHHRESILEDAIEAIIGAVYLDSNIECCKALILSWFERRLMVIKPGNEQKDPKTRLQEFLQGRKIPLPTYEVIDTTGQSHNQEFTVRCQTSVISEVVIAKGTSRRKAEQEAAQQILALIEKEREQEKEVKIKPTKQAKLANPRHTKSNPSSSSKKSSTRK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_ECOLC
Sequence: MTTNTHTLQIEEILELLPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEATMMCARSREA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDB26_FUSPC
Sequence: MFDLDPINAAFYDQIKDLPCPHQMGGYQQAYDSLEQIQKHDAAPDIDTTTIQVGKRYGPTTVTLFRLKTLVDKPLPMVFYTHGGGWIMGSAKSFAVLMEDLARRTQAVIVFPDYTRVPHQTFPYPLEQSYEVLDYMVRHSNQHQILHGTIALAGDSVGGHMAIAMMQMSLERKLPTQIGQLVLWAPVTITYKKLGSYTTFSHAPFLTEDSMDWMIESFLPNKEDRQTALASPLTHLSDEVLAQFPPTIIFLSTVDPLLDEGVAFGHRLQKNGVDASIMKAEGQMHAFCAVKALRDGPTARAVIDLAALRLRRIFPQRDTPGHPS
What is the function of this protein?
Esterase; part of the Fusarium detoxification of benzoxazolinone cluster involved in the degradation of benzoxazolinones produced by the host plant (PubMed:26296598, PubMed:25727347, PubMed:26828593).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (By similarity).  The first step in the detoxification of benzoxazolinones involves the hydrolysis of the cyclic ester bond of benzoxazolinones by the gamma-lactamase FDB1 to aminophenols (PubMed:26296598).  FDB1 is able to convert 2-benzoxazolinone (BOA) into 2-aminophenol (2-AP), as well as 6-methoxy-2-benzoxazolinone (MBOA) into 5-methoxy-2-aminophenol (2-AMP) (PubMed:26296598, PubMed:25727347).  The N-malonyltransferase FDB2 then metabolizes aminophenols via N-malonylation to non-toxic malonamic acids (PubMed:26296598).  FDB2 converts 2-AP into N-(2-hydroxyphenyl) malonamic acid (HPMA) and 2-AMP into N-(2-hydroxy-4-methoxyphenyl) malonamic acid (HMPMA) (PubMed:26296598).  The cluster contains also 2 transcription factors (FDB3 and FPSE_08121), an aldo-keto reductase (FPSE_08125) that possibly associates with a ketone component of BOA and MBOA degradation, an esterase (FPSE_08126), an acyl-CoA transferase (FPSE_08120), a solute carrier protein (FPSE_08119) and a transmembrane transporter (FPSE_08127) proposed to shuttle metabolites of benzoxazolinone degradation (Probable).
What are the official names of this protein?
Esterase FPSE_08126, Fusarium detoxification of benzoxazolinone cluster protein FPSE_08126, FDB cluster protein FPSE_08126.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase 3 family.
Protein: RHAM_LEPCP
Sequence: MTTEKIAFRMFLNPGCEAEYQLRHDRIWPELVALLKNSGVSDYSIFLDEPRGVLFAVLSRSPGHTMQTLPQHPVMQRWWQHMKDIMRCNPDGSPVAEPLPCLFHLD
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_LISMO
Sequence: MHIALIAHDEKKDLMVGFATAYKHLLEPHQLYATGTTGLRIIEATGLTVHRFKSGPLGGDQQIGARISENKMDLVIFLRDPLTAQPHEPDVTALIRLCDVYEIPLATNIGTAEILIRGLGAGFLDWRDLRRNDE
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: MDAR2_ORYSJ
Sequence: MGRAFVHVILGGGVAAGYAALEFARRGGYSRGELCIISEETVAPYERPALSKGYLLPEGAARLPGFHTCVGANDELLTAKWYKENGIELVLGTKVITADVRMKTLLTATGETISYKNLIIATGARALKLEEFGISGSDASNICYLRNLDDADKLVNVMKSCPGGNAVVIGGGYIGMECAAALVTNRIKVTMVFPESHCMARLFTPKIAEYYENYYTSKGVTFVKGTVLTSFEKDSTGKVTSVILKDGKHLPADMVVVGIGIRASTGLFEGQLLMEQGGIKVNGQMLTSDGSVYAVGDVAAFPIKLFDGVIRRLEHVDSARRTARHAVAAILEPSKTKDIDYLPFFYSRVFTLSWQFYGNNTGEVVHFGDFTNSSPRFGAYWVDKSRIRGAFLEGGSREEYEAISNVVRRKAKVINIAELEKQGLMFAIQESQKDLPDGGLALGEKPTYVWHATAGVIAAASIAAFGYWYGRKRRRW
What is the function of this protein?
Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process.  Ascorbate is a major antioxidant against reactive oxygen species (ROS) and nitric oxide (NO).
What are the official names of this protein?
Monodehydroascorbate reductase 2, peroxisomal, OsMDAR2, OsMDHAR2.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: KLK12_RAT
Sequence: MWLQILFLVLSVGRIDAAPPGQSRVVGGYKCEKNSQPWQVAVINRYLCGGVLIDPSWVITAAHCYSHNYHVLLGRNNLFKDEPFAQYRVVNQSFPHPDYNPFFMKNHTLFPGDDHSNDLMLLHLSEPADITDGVKVIDLPTEEPKVGSTCLASGWSSTKPLEWEFPDDLQCVNINILSNEKCIKAHTQMVTDVMLCAGELEGGKDTCNGDSGGPLLCDGVLQGITSWSSVPCGETNRPAIYTKLIKFTSWIKEVMKENS
What is the function of this protein?
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
What are the official names of this protein?
Glandular kallikrein-12, submandibular/renal, RSKG-3, Tissue kallikrein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
Protein: FSR2_GIBF5
Sequence: MDKADRDAVIEHATQVKRLVHDPHSFLTELVAQQQQYHCIAWLCHFNILSNIPQPPESIAYSDVATKAQVPLSKLQSVARMAMTTGLLSETKDGKLSHNTLSAQFITNVHMKTQLLHIVNQTVPLMTGLIQATWKWGETSATNETAYNIIHGTELSFFEHLKTRPDLNEGFQAYMKSRAVSHTGSNVEHLLNAFDWKALGQAQVVDIGGSSGSTSIMLATAFPLLNLVIEDLPEPIENAKARLSELPSDIKSRIEIMAYDFFTPQPVKNADVYLLRTILHDWPDADAIKIIQGIVAAMGPSSRLLIMDMVLPKPGSGSVTFEAALRQKDLTMIQCFNAQEREVEEWKALLTKADPRLKIQAIERPAGSELSVIEAMLDESPEQAAWF
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of fusarubins, highly pigmented naphthoquinones responsible for the coloration of the fruiting bodies (PubMed:22492438, PubMed:23825955).  The non-reducing polyketide synthase FSR1 is responsible for the condensation of seven acetyl-CoA units to yield a haptaketide (PubMed:22492438).  After rings A and B are formed by aldol-type cyclization, the PKS-derived product is released as 6-O-demethylfusarubinaldehyde (PubMed:22492438).  Then, two hydroxyl groups at C-5 and C-10 are incorporated by FSR3, and simultaneously hydroxyl groups at C-6 and C-8 are methylated by FSR2 (PubMed:22492438).  The aldehyde is, on the one hand, reduced by FSR3 to 8-O-methylfusarubin alcohol, which equilibrates mainly with 8-O-methylfusarubin and only small amounts of 8-O-methylnectriafurone (PubMed:22492438).  On the other hand, the aldehyde can be oxidized to form 8-O-methylfusarubinic acid, a reaction driven by FSR3 equilibrating with 8-O-methylfusarubinlactone, finally resulting in 8-O-methylanhydrofusarubinlactol after a further reduction step and loss of water (PubMed:22492438).  8-O-Methylfusarubinic acid can also undergo decarboxylation, resulting in 8-O-methyl-13-hydroxynorjavanicin after another hydroxylation step at C-13 (PubMed:22492438).  Both steps are most likely also accomplished by FSR3 (PubMed:22492438).  No enzymatic function has been determined so far for either FSR4 and FSR5 (PubMed:22492438).  Their deletion does not alter the product spectrum, but the possibility that they catalyze specific enzymatic steps during perithecium development cannot be ruled out (PubMed:22492438).  FSR4 might possess a regulatory function in the biosynthesis of fusarubins (PubMed:22492438).
What are the official names of this protein?
O-methyltransferase fsr2, Fusarubin biosynthesis cluster protein 2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: AAE_RAUSE
Sequence: MGFARLLHLVFSLLVFAGITNGLICPFDSIYQLGDSFSDTGNLIRLPPDGPTFTAAHFPYGETFPGTPTGRCSDGRLIIDFIATALNLPLLNPYLQQNVSFRHGVNFAVAGATALDRSFLAARGVQVSDIHSHLSAQLNWFRTYLGSICSTPKECSNKLKNALFILGNIGNNDVNYAFPNRTIEEIRAYVPFITEAVANATREIIRLGGSRVIVPGIFPIGCVARNLNFLNFFPDGDKDDLGCLSSLNNLSIYFNSLFQRALASLSIEFPQAVIIYADYYNAWRFLFRNGPALGSNSTSLLKCCCGIGGPYNYDPDRECGSRGVPVCPNPTQYIQWDGTHFTQAAYRRVAEYVIPGIIKALKCSYSNIQPFLREGEGRQALRLNERE
What is the function of this protein?
Deacetylates 17-O-acetylajmaline and 17-O-acetylnorajmaline, but is inactive toward other acetylated alkaloids.
What are the official names of this protein?
Acetylajmalan esterase.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
Protein: Y2588_THIDA
Sequence: MAIRDWPEDARPREKLLKQGAAALTDAELVAVFLRTGVAGKSAVDLGRDLIERFGGLGALCRADRVAACRAPGVGEAKYALLQAVMEMARRTLAEDMQAGDALSSPAAVRDYLRLILRDKEYEVFCCVFLNAQNRVIAVEELFRGTLTQTSVYPREIVKRALAHNAAAMILAHNHPSGVNEPSQADRSLTRRLAEALALVDIRVLDHFIIAGASALSFAEAGHL
What are the official names of this protein?
UPF0758 protein Tbd_2588.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: MNTP_OCEIH
Sequence: MPFTSEIISIILLAIGLSMDGFSVSLGLGMQQLRLKRIAYIGLTIGFLHMLMPLAGMLLGQVISEQIGQWTSFAGGVLLFLIGAHMFFSAFRLTEGFRWQPVGVGLWIIAFSVSLDSFTVGLGLGISGVQIFVTLFAFGIVSCFLTWLGMLIGRKVYRFLGVYSELLGGSILCGFGIFILFS
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KEX1_CANDC
Sequence: MKFLLPTFIIFIYTLLVSALPTKEGSDPKAAKKYLVSDLPGLHDNITPDDSIPLMFAGQLEIYPESNTHYFFWKFSDSNQETITNRTIFWLNGGPGCSSMDGALLETGPFRINSQQQVISNNGSWHKSGDIIYVDQPAGTGFSYSDTYITDLDQVANYFLKFMEAYYELFPQEINNEIYFAGESYAGQYIPYIANAILQRNKKLHEGEQKYDLRGVLIGNGWVSPNEQSLSYLPFFKDHGLIDIHHPKWATLLAKHEQCQKIVNKIDSTFDDGTVHYYEVSSSTCEAILTDLLEYTQDTANDKNQQCINMYDYTLRDSYPSCGMNWPNELVNVGPFLRQEKVMHQLNLINLKKWNECNGKVGRTFQARHSIPSVHLLPELAKEIPVMLFNGANDIICNSQGVLSYLQKLQWNGETGFINKDNQISWVYDNKEVGYMLWERNISFINIYNSSHMVPYDLPDVSRALIDLITGEYDEKDVDGKKSFVTYPLGSRKENDESKNPVESPSQTIDPIISSSSSSVESSLSSSSASATDSDSTSSKFTRLIQLAVILVIFWGVYVLYASYKSRPSSIIKKPTNNTSNITRSSTGKKKNVQWADQLNQFEDDERNQESNQGIIAKAIGKITGSKDTRGRYAPVHRENDNEYIDDIELGEGISDPNVDEFIIGSDDDDEEEQPRSDPATHKSVS
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: Y1999_ACICJ
Sequence: MKNLAGLMKQAQQMQQNMQEMQTRLEAMEIRGEAGAGLVKVTLSGKGEMKGIEIDPKLIDPNDAEMLQDLIVAAHRDAKSRLETLAAEEMQKVTGGISLPPGMKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Acry_1999.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: TRPB_STRTD
Sequence: MTYQQPDAKGFYGKFGGQFVPETLMTAVIELDKAYREAKEDSSFQAELDDLLKNYVGRETPLYHAKRLTDHIGGAQIYLKREDLNHTGAHKINNALGQVLLAKRMGKKKIIAETGAGQHGVATATAAALFDMDCTIYMGEEDVKRQALNVFRMELLGAKVFSVTDGSRVLKDAVNAALRAWVAGIDDTHYIMGSALGPAPFPEIVRDFQSVIGREVKRQYAEISGGKLPDAVMACIGGGSNAIGMFYPFVNDKSVAMYGAEASGLGLDTEKHAATFAKGRPGILHGALMDVLQDAHGQIMEAFSISAGLDYPGVGPEHCYFNEIGRATYDSITDEEALEGFKLLSRLEGIIPALESSHAIALAQKVAAKMSPDQSLIVCLSGRGDKDVMQVKERFEAEAEGK
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: FLS4_ARATH
Sequence: MEVERDQHKPPLSLQNNKIPSSQNFPVVDLSNTNGELVARKVAKASEEWGIFQVVNHGIPTELIRRLHKVDTQFFELPESKKEAVAKPANSKEIQGYEMDDVQGRRSHIFHNLYPSSSVNYAFWPKNPPEYREVTEEFAKHAKQLAEEILGLLSEGAGYLMKINYYRPCPEPDWVMGIKAHTDFNGLTLLIPNEIFGLQVFKEDRWLDVDYIYPAVIIIIGDQIMKMSNGRYNNVLHRALMDKKKTRMSSVVHIKPPYDMVVSHFPNSPAAIILPSSSL
What are the official names of this protein?
Probable flavonol synthase 4.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.