PharMolix/UniProtQA huggingface dataset:
Protein: Y318_AERS4
Sequence: MQLIVVSGRSGSGKTVALRVLEDLGYYCVDNLPVNLLPQLIVSVESQYDKLAVSIDVRNLPVSADKLETLLAQVRNEGRVEFSSFFFDAENSTLLKRYGESRRLHPLSRKQLSLDEAIREETNLLAPLSSTADLRIDTTSLSIHDLSELIKTRVLGKKENELVLVFESFGFKYGIPKDADFVFDARFLPNPHWIPELKPFTGKDEPVARYLSSQPDVMQFILQIENMLATWLPHLERNNRSYVTVGIGCTGGQHRSVFIAEQLAGAFRLLGKNVQIRHRTLDKSTPQH
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein ASA_0318.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: DC1L2_PONAB
Sequence: MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRAGSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSFPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVTNSSTENEA
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in binding dynein to membranous organelles or chromosomes.
What are the official names of this protein?
Cytoplasmic dynein 1 light intermediate chain 2, Dynein light intermediate chain 2, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the dynein light intermediate chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SURE_EHRRG
Sequence: MRVLLSNDDGFHANGIKALKEIVIKSGIASEIWVVAPLNNCSGSGRSVGLNVKVQVSKVSDTEFIVDSTPSTSVFLALRKIMNYKPDLILSGINHGVNIGNDVWYSGTVAAAAEGAAINIPSIAISQEYDNKSGEINWVNPQRFLKQIIEMLVNVSFWNKSTVMNVNFPLMPAKGIKFTDQGKYVPCNEIEKNESSDDSNVSYTITRITPNKKNRAQCDGSIKAIDEGYITITPLKFDMTDFDVLTSLNSLK
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAZ_PANTR
Sequence: MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADICFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQPGR
What is the function of this protein?
Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity).  Its role in cellular physiology is to improve mitochondrial performance (By similarity).  CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity).  Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL.  Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations.  Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate.  Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution.  Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor.  CoA-independent, it can reshuffle molecular species within a single phospholipid class.  Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL.  Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane.  Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes.  Essential for the final stage of spermatogenesis, spermatid individualization (By similarity).  Required for the initiation of mitophagy (By similarity).  Required to ensure progression of spermatocytes through meiosis (By similarity).
What are the official names of this protein?
Tafazzin, Taz.
What is the protein family that this protein belongs to?
Belongs to the taffazin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: RLMN_PSEU2
Sequence: MIASTGKTNLLGLTQQEMEKFFDSIGEKRFRAGQVMKWIHHFGVDDFDAMTNVSKALREKLKACAEVRGPEVVSEDISSDGTRKWVVRVESGSCVETVYIPQGKRGTLCVSSQAGCALDCSFCSTGKQGFNSNLTAAEVIGQVWIANKSFGSVPATVDRAITNVVMMGMGEPLLNFDNVIAAMHLMMDDLGYGISKRRVTLSTSGVVPMIDELSKHIDVSLALSLHAPNDALRNQLVPINKKYPLKMLLESCRRYMSSLGEKRVLTIEYTMLKDINDKVEHAVEMIELLKDTPCKINLIPFNPFPHSGYERPSNNAIRRFQDLLHQAGYNVTVRTTRGEDIDAACGQLVGQVMDRTRRSERYIAVRELSAEADAAPVAVTRT
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMC2_DANRE
Sequence: MSSISELYDVTWEEMRDKLRKWREENYRNSEQIVDVGEELINEHASKLGDDIWIIYEQVMIAALDCSRDDLAWSCLQELKRQFPDSHRVKRLAGMRLEALERYDDANKLYDSILQDDPTNTAARKRKICILRAQGKSSEAIRELNEYLEQFVGDQEAWHELSELYINEHDYAKAAFCLEELMMTNPHNHLYCEQYAEVKYTQGGLENLELARKYFAQALKLNNRNMRALFGLYMSASHIAASPKVSAKVKKDNVKYAAWAAAQISRAYQMAGRGKKENKCSVKAVEEMLESLQITMS
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 2, Tetratricopeptide repeat protein 35, TPR repeat protein 35.
What is the protein family that this protein belongs to?
Belongs to the EMC2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FAF2_MOUSE
Sequence: MAAPEEQDLTQEQTEKLLQFQDLTGIESMEQCRLALEQHNWNMEAAVQDRLNEQEGVPSVFNPPPARPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNALCAPEVISLINSRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREEKERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCVPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE
What is the function of this protein?
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.  By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.  Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.
What are the official names of this protein?
FAS-associated factor 2, UBX domain-containing protein 8.
What are the subcellular locations of this protein?
Cytoplasm. Lipid droplet. Endoplasmic reticulum.
Protein: SODCP_PINPS
Sequence: HAGDLGNIVAGSDGV
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Probable superoxide dismutase [Cu-Zn], chloroplastic, Water stress-responsive protein 15.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BRK_AMICA
Sequence: RPPGWSPFR
What is the function of this protein?
Induces smooth muscle dilation and contraction.  Intra-arterial injection induces a significant decrease in ventral aortic blood pressure of between 5 and 10 minutes duration followed by a dose dependent increase in ventral aortic blood pressure of between 30 and 60 minutes duration.  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
[Trp5]-bradykinin.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYS_STAA3
Sequence: MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIALKKRNKENADDVIAEMRTLGDDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDEDNVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSGARFVYLTNEGAQLERALMNYMITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFYRNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALEEMTTNAEAILEELGLPYRRVILCTGDIGFSASKTYDLEVWLPSYNDYKEISSCSNCTDFQARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENYQNEDGTVTIPEALVPFMGGKTQISKPVK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_VIBVU
Sequence: MAIVKCKPTSAGRRHVVKVVNADLHKGKPYAPLLEKNSKNGGRNNNGRITVRHIGGGHKQHYRVVDFKRTKDGIPAKVERLEYDPNRSANIALVLYADGERRYIIAPKGMQAGDVIQSGVDAPIKAGNTLPMRNIPVGSTIHCVELTPGKGAQLARSAGAYAQLVARDGSYVTIRLRSGEMRKVLSEGRATIGEVGNSEHMLRELGKAGASRWRGVRPTVRGVVMNPVDHPHGGGEGRTSGGRHPVSPWGVPTKGYKTRSNKRTDKYIVRRRNK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SPC1_YEAST
Sequence: MSEILQDVQRKLVFPIDFPSQRKTEKFQQLSLMIGALVACILGFAQQSLKVLLTAYGISCVITLICVLPAYPWYNKQKLRWAQPKIEINVDQYD
What is the function of this protein?
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:8663399).  Dispensable for SPC enzymatic activity (PubMed:8663399).
What are the official names of this protein?
Signal peptidase complex subunit 1, Microsomal signal peptidase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the SPCS1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CA074_DANRE
Sequence: MVASSPETLISAAQKCLCSRKKRLSPSSCLEVTIHIIAVDLGVKPALLYDSNGASPDQLQLYLHSLQESSVVSNSLRIMSINDNTFIINPDIMKSHLGELLKSKSLPLIDVCSSRKRPVLCAFERSAEEMVRSFLEVFMNGLDLVVLEEELYKDWNLCTFFGILLGYPASYWFEQTQGFENCLSMTPLVVCTVWVRWQIHEIKQRCCLYSFSVPEELWSDVQSHIQRWTDHLRERFSKQTVLTDICFSRDTVTLPSVTL
What are the official names of this protein?
UPF0739 protein C1orf74 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0739 family.
Protein: RL14_CHLPB
Sequence: MIQKETNLVVADNSGAKKVRCIHVFGGTGRRYASLGDQIMVTVKAAVPGGVVKKKEVTKAVVVRCAKEKRRKDGSYIRFDENAVVLLNAQGEPRGTRIFGPVARELRDKKYMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: TIG_BORA1
Sequence: MQPVVETLSGLERRVDLAISVADVEKEVQAQLKRVARTAKVPGFRPGKAPMAMLERSHGPSVRYDVINSQVARAFEQAVEAAQLRVAGSPSLEPKTEGVDENTLAFSATFEVYPEVAVPDLSDLAVTRYETEVTDAEVDKTLDVLRKQRASYETREGRAAQDDDRIVLDFAGTIDGVPFEGGKAENFPFILGQGRMLPEFEEAARGLKAGDTKVFPLSFPEDYQGKEVAGKTAEFTITVKEVAEAVLPVVDAEFAKSLGQADADVEKLKADIRGNIEREVKVRSQGRTKTSVMDALVEAAKFDVPKSLVDNDVQGRIAQAREELKQRGVPNADSMPMPAEVFAVESERRVRLGLLVSELVKQQQLQAKPEQVRARIEEFAQNYEQPAQVVSYYLSDRQRRAEIEAIVLEDNVVAYVLEKAKVTDEKVPFDQLMGMA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: NLTP4_ARATH
Sequence: MAFALRFFTCFVLTVFIVASVDAAITCGTVASSLSPCLGYLSKGGVVPPPCCAGVKKLNGMAQTTPDRQQACRCLQSAAKGVNPSLASGLPGKCGVSIPYPISTSTNCATIK
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
What are the official names of this protein?
Non-specific lipid-transfer protein 4, LTP 4.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: VP321_ARATH
Sequence: MFMNRLFGKPKQETSTLQTLDKLNETLEMLEKKENVLLKKATGEVEKAKEFSRAKNKRAAIQCLKRKRLYEQQVEQLGNFQLRIHDQMIMLEGAKATTETVDALRTGASAMKAMQKATNIDDVDKTMDEINEQTENMKQIQEALSAPFGANDFDEDELEAELDELEGAELEEQLLQPVPIHVPQGNKPARAPAQKQPTAEEDELAALQAEMAL
What is the function of this protein?
Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 32 homolog 1, AtVPS32-1, Charged multivesicular body protein 4 homolog 1, ESCRT-III complex subunit VPS32 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Endosome.
Protein: YFCJ_SALTI
Sequence: MTAVSQKTTTPSADFSLFRIAFAVFLTYMTVGLPLPVIPLFVHHELGYSNTMVGIAVGIQFFATVLTRGYAGRLADQYGAKRSALQGMLACGLAGAAWLLAALLPVSAPVKFALLIVGRLILGFGESQLLTGTLTWGLGLVGPTRSGKVMSWNGMAIYGALAAGAPLGLLIHSHFGFAALAGTTMVLPLLAWAFNGTVRKVPAYTGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFISLYFVSNGWTMAGFTLTAFGGAFVLMRILFGWMPDRFGGVKVAVVSLLVETAGLLLLWLAPTAWIALVGAALTGAGCSLIFSALGVEVVKRVPAQVRGTALGGYAAFQDISYGVTGPLAGMLATSYGYPSVFLAGAISAVVGILVTILSFRRG
What are the official names of this protein?
Uncharacterized MFS-type transporter YfcJ.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YfcJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LCL2_KLULA
Sequence: MKLLGTIIGSAFFLQAVSGFFFDSGHQNRQQQQQQQQQRDVGSYQQMFLDNDCPHYLCPQTLDCVRQKSDCACPFPNSQLKCNLPNGQVICISKPATHDPTLVEIYDDPVMGPAQRTEGFRDCGWILDVYDGKI
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.
Protein: ILIE_HYPJQ
Sequence: MAELHASLPITLRCGLTLPNRLVKASMSEGISAAGSLPDMKIRNIYQRWAKGGWGMVITGNVQVDDRYLGTANDLAVDSRASDDTIVASWSRWAKVCRQHGTPTLVQLNHPGRQCPIGAGTHGYLSKNVAPTSIGLHMGDGLIPKAVSAIAFGKPRELEIAEIRTITQQFARAARLAYRSGFAGVEIHAAHGYLIDEFLTERTNRRSDAYGGSTERRAKFLIDIISAVRSEVPSSFCVGVTINSVDSVFPEILVDRVRQLELVTSAGVDFIEISGGTFEDPLMFLGPPKPSSSANMEHSEAYFVDFAKVVASKFPDVPLLLTGGFRCRESIEKAVTNGACSMVGIARPAAVNPLLPKTVMFNHEVKDSDATLYSPKIEAPWLIRQMGITALSVHMDNVSSF
What is the function of this protein?
NADH-dependent flavin oxidoreductase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:34947016).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (PubMed:34947016) (Probable).
What are the official names of this protein?
NADH-dependent flavin oxidoreductase iliE, Epimerase iliE, Ilicicolin H biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: COX2_DAUCA
Sequence: MSFTGIFHFFTNSPCDAAEPWQLGSQDAATPMMQGIIDLHHDIFFFLILILVFVSRILVRALWHFHSKKNPIPQRIVHGTTIEILRTIFPSIIPMFIAIPSFALLYSMDEVVVDPAMTIKAIGHQWYRTYEYSDYNSSDEQSLTFDSYTIPEDDPELGQSRLLEVDNRVVVPAKTHLRIIVTSADVPHSWAVPSSGVKCDAVPGRLNQISISVQREGVYYGQCSEICGTNHAFTPIVVEAVSRKDYGSRVSNQLIPQTGEA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: G6PI_PARP8
Sequence: MTLNSLPAWNSLQTHYGQIRDARLRDWFAPENDPAPTRAERFTLSGGGLAADFSKNRITDDTLKLLVQLAREAQVETRRDAMFAGETVNPTEGRAVLHTALRASNPTSPFYGKVQAERAKMAAFADKVRSGEWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALQHLATPEISTHFVSNVDGADLYRVLQQINPEETLAIIVSKTFTTLETMTNANSLRDWFIQKGCPESELAKHFVGVSANPAEVVKFGIAQENVFEMWDWVGGRYSLWSAVGLSIVIAIGPKQFDELLAGANEMDEHFRSAPLERNLPVLMGMIGIWYRNFFGSQSYLVAPYSEALHFLPSYLQQLEMESNGKQACLDGSFVTYDTSAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFVAVLTPEHPLVSHHPKLLANCFAQSEALMLGRTREEAEKVAGRDKPDLVPHIMFPGNRPTTTLLVDALTARSLGALIALYEHKVLVQGTVWNINSFDQWGVELGKILGKVVEADLTAATVDETKHDSSTSALIARARAALKR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCB_BORA1
Sequence: MAADDYFSLFGLPSKFAIDAQALEEAWRLVAARVHPDRYATASAAERRVAMQWAARANEAYRLLRDPMLRARYLCESAGIDLQTESNTAMAPAFLMQQMEWREMLDDARHDERARAALGEELEQAREAMRASLAELIDTRQDYAAAGQKVREWMFIEKLAQELAAVQP
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: CST8_HUMAN
Sequence: MPRCRWLSLILLTIPLALVARKDPKKNETGVLRKLKPVNASNANVKQCLWFAMQEYNKESEDKYVFLVVKTLQAQLQVTNLLEYLIDVEIARSDCRKPLSTNEICAIQENSKLKRKLSCSFLVGALPWNGEFTVMEKKCEDA
What is the function of this protein?
Performs a specialized role during sperm development and maturation.
What are the official names of this protein?
Cystatin-8, Cystatin-related epididymal spermatogenic protein.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Secreted.