PharMolix/UniProtQA huggingface dataset:
Protein: NDHO_SYNSC
Sequence: MAESDAAAPAKAKPAALRKGALVKVNRAAYSSSLEAGASDPTAPDYIFEGPGELLVVKGDYGQVRWNRPVPDVWLRMDQLEACS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit O, NAD(P)H dehydrogenase I subunit O, NDH-1 subunit O, NDH-O.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhO subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SWR1_CANGA
Sequence: MSKNNKLNGKDNRQSKIEKLSELKLRHDQLTNELYHLHEYISLVEYDPFYIPNSENYERLLEEKDVTWGSIFQEKKQLHNESSGKKVRRSVRHLRDSGSSTINELDTMSENDINLLKEVDILAKQKLQDLKLQFSNSHIKKKGNTKRAKIVKQVPNHQDKSESPQISERDVKTVVKDLKPNHRGSEIKPEIMESSDVKNEIENCDFNEKQLKLYKDDDIASESDFYFTTSSEDELPNKRRGTIKRRKRINLYVNPPKAVITNPDNIANSHYPTLHEYLDSFKILEDDMTNEEYNTFIKEQQRFAKMIKKGIETGALKYDPVTETVQPSARKVPNMFSHAKVDPIQYMYKEQNLHIHQEHLINQGLFSSKLVQNRKKQRIAGAKKIAQMIEQHFKHIAGAEDRRLKENEKQRKAIARNIIQSVKKRWNLAEKAYRILKKDEEEQLKRIQGKEHLSKMLEKSSKLLGAQLKQHPNEDDIENSTSDDFSSTGDSDNLSSSSDEESDDEINDLSEDQKNNINELKTSSTSAFSSPEISSPSKNPDLGLNSLLTNDFENESNSSDTNEEFIMGDSDTSHSDDENLTDDSEDSNDGEHDTTSDNEKSDLFPADTTNDPLAVQDVPTPSLLRGTLRTYQKQGLNWLASLYNNNTNGILADEMGLGKTIQTISLLSYLACEKHNWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGNPQQRKEKRKGWNKPDAFHVCIVSYQLIVQDQHSFKRKKWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRILLTGTPLQNNIAELWSLLYFLMPQTVIDGQKVSGFADLDAFQQWFGRPVDKLIETGGTYEQDNETKRTVEKLHQVLRPYLLRRLKADVEKQIPGKYEHIVYCKLSKRQRFLYDDFMSRAQTKATLASGNFMSIVNCLMQLRKVCNHPDLFEVRPIKTSFLFGESVIARYSERANSITRRIHFHDKDTLVDLQNINLQFTNNDLEKTSYHTNTINKLACINEFVEEVQKLRKQNAEEERQKSRHLKINTQNISNFYEEFMQQKLDEQENKINFIGYLNSQRCSRKTVYGMNLIRLLEMPHVSNNCIDDPNYDDLIKPLQTRLLDGRTTIEKFAVLTPGAVTSNIGELTLGMDEFVTPNSKSGIIPYEELVQLDNPFHQVQTKLTIAFPDKSLLQYDCGKLQKLAILLQQLKDGGHRALIFTQMTKVLDILEQFLNYHGYLYMRLDGATKIEDRQILTERFNSDPKITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQTRDVHIYRFVSEHTIESNILKKANQKRQLDDVIIQKGEFTTDYFSKLSVKDLFGSDVVGDLPVIDTKPLLGSDSEAIKDPKKLEKLLAQAEDEDDVKAANSALREVNVDDEDFDESSTNKTGGNILNGDDIDEDVDEYEGTNHVEEYMLRFIANGFYF
What is the function of this protein?
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
What are the official names of this protein?
Helicase SWR1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SLI1_YEAST
Sequence: MNLKLSAIESYFFHRSRLNLHSCFYVGIKLNELPKKSQLIAALKYTVIQHERLTCNVFYDELKKENFLQNILEPLKFCDLVEYRHDWDQLGETEINHIFQRYNFSYNENKPLWKILILPNQNQMLLLTDHVLMDGMSAIHVWETFMEGLQMQQPVEIDETIYSPSLNSSTEKIMSAPLYGDWPIPWNWHIVRQLVSRLHYWFPQTVVKNNRNLIQFANYSFPKDLLDDKPSDGTQKYKVKNTNHQWEFRLSPTHLNDILQECKANNTSLTSLLGALVCTSFEKIAAHEYTGSFLKIELPMNIRKPFERVLKLPSDDKLAVGNFIAVIEFNHKLHQNRGIWDIASQIQRAIRSSSEDKIIDKVNEVKLLEVISSQQYIEDKISLNNGPSSTFEVTNLGFQTFKDACNTSLPFYIVDATFNEPQGISSIFSLSVISTPGNGLHCCISYPNTLTKVLEPHWQYMKDYLNLY
What is the function of this protein?
Confers resistance to the sphingolipid biosynthesis inhibitor drug myriocin (ISP-1).  Inactivates ISP-1 by converting it into N-acetyl-myriocin.  Cooperates with YPK1 in mediating resistance to myriocin.
What are the official names of this protein?
N-acetyltransferase SLI1, Sphingosine-like immunosuppressant resistant protein 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: WFDC2_CANLF
Sequence: MPACRPGPLAGALLLGLLLLGLPRVPGGEVEKTGVCPQLQADLNCTQECVSDAQCADNLKCCQAGCATICHLPNEKEGSCPQVNTDFPQLGLCQDQCQVDSHCPGLLKCCYNGCGKVSCVTPIF
What is the function of this protein?
Broad range protease inhibitor (By similarity).  Possible function in sperm maturation.
What are the official names of this protein?
WAP four-disulfide core domain protein 2, Epididymal secretory protein E4, CE4, Major epididymis-specific protein E4.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPA_WOLPM
Sequence: MHSKPQWLRAKAPTGEVFNETLNIVKLHNLHTVCEEAACPNIGECWNKRHATVMILGSVCTRACAFCNVATGIPDKLDPHEPENLAKAIKKLNLKHVVITSVDRDDLPDGGANQFIQCIEEIRKITSETTIEILTPDFLNKKGAFEAIAVASPDVYNHNIETVPRLYAKIRPRARYFHSLYLLKMVKQINPKVFTKSGLMVGLGETKEEILQVMDDLRSAEVDFITIGQYLQPTPKHAKLDRYVTPEEFEHYKYIAYSKGFLVVASSPLTRSSYHAEEDFNRLKACR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_SOLUE
Sequence: MPDLKSLIREVPDFPKPGILFYDITTLLKDPSGFHGVIDGLKDHYRDIKVDTVLGIEARGFIFAPALAYALGAGFVPVRKPKKLPAECVRITYDLEYGTDTLEMHKDAIGNGHRVLIVDDLLATGGTASAAARMVQDAGGIVVGLGFVIELTFLAGRQRLNGHDVFSLLQYDK
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOY_STRPC
Sequence: MIYKVFYQETKDQSPRRESTKALYLNIDATDELDGRIKARRLVEDNTYYNVEFIELLSDKHLDYEKETGVFELTEF
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: YS1_MAIZE
Sequence: MDLARRGGAAGADDEGEIERHEPAPEDMESDPAAAREKELELERVQSWREQVTLRGVVAALLIGFMYSVIVMKIALTTGLVPTLNVSAALMAFLALRGWTRVLERLGVAHRPFTRQENCVIETCAVACYTIAFGGGFGSTLLGLDKKTYELAGASPANVPGSYKDPGFGWMAGFVAAISFAGLLSLIPLRKVLVIDYKLTYPSGTATAVLINGFHTKQGDKNARMQVRGFLKYFGLSFVWSFFQWFYTGGEVCGFVQFPTFGLKAWKQTFFFDFSLTYVGAGMICSHLVNISTLLGAILSWGILWPLISKQKGEWYPANIPESSMKSLYGYKAFLCIALIMGDGTYHFFKVFGVTVKSLHQRLSRKRATNRVANGGDEMAALDDLQRDEIFSDGSFPAWAAYAGYAALTVVSAVIIPHMFRQVKWYYVIVAYVLAPLLGFANSYGTGLTDINMAYNYGKIALFIFAAWAGRDNGVIAGLAGGTLVKQLVMASADLMHDFKTGHLTMTSPRSLLVAQFIGTAMGCVVAPLTFLLFYNAFDIGNPTGYWKAPYGLIYRNMAILGVEGFSVLPRHCLALSAGFFAFAFVFSVARDVLPRKYARFVPLPMAMAVPFLVGGSFAIDMCVGSLAVFVWEKVNRKEAVFMVPAVASGLICGDGIWTFPSSILALAKIKPPICMKFTPGS
What is the function of this protein?
Involved in Fe(3+) uptake.  Acts as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals.  Capable of transporting either Fe(2+)-nicotianamine or Fe(3+)-phytosiderophore.  May transport iron, zinc, nickel, copper and, at a lower rate, manganese and cadmium.
What are the official names of this protein?
Iron-phytosiderophore transporter yellow stripe 1, ZmYS1.
What is the protein family that this protein belongs to?
Belongs to the YSL (TC 2.A.67.2) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ENO_PSYWF
Sequence: MYAENITNAVEIQDIRAREILDSRGNPTIEADVILADGSMGRAAAPSGASTGSREALELRDGDKSRYLGKGVTKAVANVNSQIRSALLESDATDQQGIDNILIELDGTANKDHLGANAMLAVSLATAKAAAISQNLPLHQYIANLRGQTSLTMPVPMMNILNGGEHADNTVDIQEFMIEPTGFSSFSEALRAGVEIFHSLKSVLKSQGLNTAVGDEGGFAPNLRTNEEAITVIMQAIEQAGYKAGKDIHLALDCAASEFYKNGQYILAGEGNKTFDSQGFSDYLVKLTEQYPIISIEDGLDESDWEGWAYLTSKLGKKVQLVGDDLFVTNPAILQEGIDKQIANAILIKFNQIGTLSETLDAIYLAKKNGYATVISHRSGETEDSTIADLAVGTAAGQIKTGSLCRSDRVAKYNQLLRIEQQVRASYRGGEEFIGLRG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SSRP_LISMH
Sequence: MPKGDGKLVAQNKKARHDYAIEETFEAGIVLQGTEIKSVRNARVNLKDSYARIDKGEIFLHNMHISPYEQGNRYNHDPLRTRKLLLHKKQISRLIGETKESGYSIVPLKMYIKDGYAKVLIGVARGKKKYDKRQDLKQKEAKRDIERAFKERQQ
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MAO1_RHIME
Sequence: MNTGDKAKSQAVPASGDIDQQALFFHRYPRPGKLEIQPTKPLGNQRDLALAYSPGVAAPCLAIKDNPETAADFTARANLVAVVSNGTAVLGLGNIGPLASKPVMEGKAVLFKKFAGIDVFDIEIDAPTVDRMVDVISALEPTFGGINLEDIKAPECFEVERRLREKMEIPVFHDDQHGTAIIVAAAVLNGLELAGKDIAEAKIVASGAGAAALACLNLLVTLGARRENIWVHDIEGLVYKGREALMDEWKAVYAQESDNRVLADSIGGADVFLGLSAAGVLKPELLARMAEKPLIMALANPTPEIMPEVARAARPDAMICTGRSDFPNQVNNVLCFPHIFRGALDCGARTINEEMKMAAVRAIAGLAREEPSDVAARAYSGETPVFGPDYLIPSPFDQRLILRIAPAVAKAAAESGVATRPIQDFDAYLDKLNRFVFRSGFIMKPVFAAAKNAAKNRVIFAEGEDERVLRAAQVLLEEGTAKPILIGRPQIIETRLRRYGLRIRPDVDFEVVNPEGDPRYRDYVDDYFALVGRLGVIPEAARTIVRTNTTVIGALAVKRGEADALICGVEGRYSRHLRDVSQIIGKRSGVLDFSALSLLISQRGATFFTDTYVSFSPSAEEIAQTTVMAANEIRRFGITPRAALVSHSNFGSRDSESAFKMRTALQLVRELAPDLEVDGEMHGDSAISEVLRQRVMPDSTLNGEANLLVFPNLDAANITLGVVKTMTDSLHVGPILLGSALPAHILSPSVTSRGVVNMAALAVVESSHPV
What is the function of this protein?
Required for symbiotic nitrogen fixation.  Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria.
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
Protein: DCAF8_PONAB
Sequence: MSSKGSSTDGRTDLANGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGPNRTSTESRGTDTESSGEDKDSDSMEDTGHYSINDENRVHDRSEEEEEEEEEEEEEQPRRRVQRKRANRDQDSSDDERALEDWVSSETSALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMRARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQRKIDENENNGVLKKFCPHHLVNGESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQYVKRYKGHRNNATVKGVNFYGPKSEFVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGLKDVIKKNKRERDEDSLHRTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGATDADSDESPSSSDTSDEEEGPDRVQCMPS
What is the function of this protein?
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
What are the official names of this protein?
DDB1- and CUL4-associated factor 8, WD repeat-containing protein 42A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DCAF8 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent.
Protein: RS17_ECOHS
Sequence: MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RECA_ECOUT
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSPA_STRP6
Sequence: MAQGTVKWFNAEKGFGFISTENGQDVFAHFSAIQTSGFKTLEEGQKVAFDVEEGQRGPQAVNITKLA
What are the official names of this protein?
Major cold shock protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGKG_RAT
Sequence: MSDGQWVCLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLKQYDPHKPISYDVFKLFMRAYLEVDLPQPLSTNLFLAFSQKPRQETPDHPKEGASSSEPNVSDSNAESTAKADAACAPDTESKPIKTQVPSEELEAAAPWGEPNAPASSSDAPIVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENELLDQAELDQIVSQMLHVAQYLEWDPTELRPILKEMLQGMDYNKDGFVSLEEWVSGGMTTIPLLVLLGMDDSASKGDGRHAWTLKHFKKPTYCNFCHIMLMGVRKQGLCCIYCKYAVHQRCVSNSIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTACDGGELKDHILLPTSIYPVTRDRQAGKSDSGAAAKGELVMQYKIIPSPGTHPLLVLVNPKSGGRQGERILQKFHYLLNPKQVFNLDKGGPTPGLNFFQDTPDFRVLACGGDGTVGWILDCIDKANFTKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKEIEQSPLVMLDRWYLEVMPREEVENGDQVPYNIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTKKLLPMQVDGEPWMQPPCMIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:7809169).  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity).  Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity).  Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma.  Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity).
What are the official names of this protein?
Diacylglycerol kinase gamma, DAG kinase gamma, 88 kDa diacylglycerol kinase, DGK-III, Diglyceride kinase gamma, DGK-gamma.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton.
Protein: GLYA_BARBK
Sequence: MIKRENDLQQCFFNDTLQTVDAAVFDAVSGELRRQCDEIELIASGNIVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCHFVDRIEELAIERAKNLFGAAFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLSSGGHLTHGSPVNMSGKWFNRIAYGLRQEDQLLDIESVERLAKEHKPKLIFAGGTAYSRIWDWKRFREISDEVGAYLVVDMAHIAGLVAGGVHPSPIPHAHIVTTTTHKSLRGPRGGMILTNDEVLAKKINSAVFPGLQGGPLMHVIAAKAVALGEALQPAFKDYAAKVVANAKILAENLQNNGFTIVSGGTDNHLLLVDLRNKSLTGKHAELALERASIICNKNNIPFDPQLPSITSGIRLGTPAATTRGFAENEFIQISDLISEVLDGLTIAKNDDENFLVEAAVKKKVKNITDNFPFYS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_STRP8
Sequence: MSKNLLIELGLEELPAYVVTPSEKQLGERLATFLTENRLSFEDIQTFSTPRRLAVRVSGLADQQTDLTEDFKGPAKKIALDADGNFSKAAQGFVRGKGLTTDAIEFREVKGEEYVYVTKHEAGKPAKEVLLGVTEVLSAMTFPVSMHWANNSFEYIRPVHTLTVLLNDEALELDFLDIHSGRVSRGHRFLGTETTITSADSYEADLRSQFVIADAKERQEMIVEQIKTLEVEQGVQVDIDEDLLNEVLNLVEFPTAFMGSFEAKYLDVPEEVLVTSMKNHQRYFVVRDQAGHLMPNFVSVRNGNDQAIENVIKGNEKVLVARLEDGEFFWREDQKLQIADLVAKLTNVTFHEKIGSLAEHMDRTRVIAASLAKEANLSAEEVTAVDRAAQIYKFDLLTGMVGEFDELQGIMGEKYALLAGEDAAVATAIREHYLPDAAGGALPETKVGAVLALADKLDTLLSFFSVGLIPSGSNDPYALRRATQGIVRILDHFGWRIPMDKLVDSLYDLSFDSLTYANKADVMNFIRARVDKMMGKAAPKDIREAVLESSTFVVPEMLAAAEALVKASHTENYKPAVESLSRAFNLAEKADASVQVDPSLFENEQENTLFAAIQGLTLAGSAAQQLEQVFALSPVINDFFDNTMVMAEDQALKNNRLAILSDLVSKAKTIAAFNQLNTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPE_ECOLI
Sequence: MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLVWLLIGLLCIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGVPAGCDEREYLRELQNALLWINFRFYLAPLFWLIVGGTWGPVTLMGYAFLRAWQYWLARYQTPHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLAQFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV
What is the function of this protein?
Putative signaling protein in beta-lactamase regulation.  AmpE seems not to act as a direct sensor for beta-lactams.
What are the official names of this protein?
Protein AmpE.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRCA_KLEP7
Sequence: MITGIQITKAANDDLLNSFWLLDSEKGEARCLCAKGGFAEDDVVAVSKLGEIEYREIPVDVKPEVRVEGGQHLNVNVLRRETLLDAVEHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: SYG_CLOK1
Sequence: MPFEKTMDKIVALAKNRGFVYPGSDIYGGLANTWDYGPIGVELKNNVKKAWWQKFVHESQYNVGIDCAILMNNEVWVASGHVGNFSDPLMDCKECKSRFRADKLVEEHMTSKGVEKASADGWNNEKLKEYIDDNNIVCPDCGKTNFTDIRQFNLMFKTFQGVTEDSKAEIYLRPETAQGIFVNFKNVQRTSRKKIPFGIAQIGKAFRNEITPGNFTFRTREFEQMELEFFCEPGTDLEWHNYWKEYCWKFLLKLGIKEENIRFRVHEKEELSHYSNATSDIEYLFPFGWGELWGIADRTDYDLTQHQNRSGKDMTYLNPVTNERYIPYCIEPSVGADRAVLAFLVDAYDEEELEGGDVRTVMHFHPAIAPFKVAILPLSKKLSEKALDVYNMLRKDFNVDYDDAGSIGKRYRREDEIGTPYCITIDFDTMDNDTVTIRDRDTMKQFRVKIDELKDFIKEKIQF
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAPB_YERPE
Sequence: MSFEVFEKLEVKVQQAIDTITLLQMEIEELKEKNNTLTQEVQDAAGSREALVRENEQLKQEQHVWQDRLRALLGKMEEV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: THIG_PORGI
Sequence: METLQIAGKTFESRLFVGTGKFASSDLMEAAVLASQSRMVTVALKRVEIGRVEEDDMISRITRHPEITLLPNTSGVRSAKEAILAAELAREALQTNWLKLEVHPDPRYLLPDPIETLRATEELVRRGFIVLPYVQADPVLCKHLEEAGAATVMPLGAPIGSNRGLKTREMIRIIIEQSRVPVVIDAGIGAPSQAAEAMEMGADAVLVNTAIAVAEDPVSMATAFRLAVEAGRMAFEAKLGSVRSEAEASSPFTSFLNLK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_BACLD
Sequence: MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIKFNGVTYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRAHVILPYHLKLDAVEEERKGANKIGTTKKGIGPAYMDKAARVGIRIADLLDRDVFEEKLARNLEEKNRLLEKMYDAEGFKIEDILDEYYEYGQQIKQYVCDTSVVLNDALDDGRRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIQHVVGVSKAYTTRVGDGPFPTELNNEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVLTGIETLKICVAYKYRGEILEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSDLPENARHYLERVSQLTGIPLSIFSVGPDRSQTNVVRSVYRPN
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_STRE4
Sequence: MIAELEGIDIRENEALKHYTYTQVGGPADFLAFPRNHYELSRIVDYANHNHIPWMVLGNASNLIVRDGGIRGFVIMFDKLNAVRLNGYTLEAEAGANLIETTKVAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEIAHIFLSAKVLTPEGKIKKISAREMAFGYRHSVIQETGDIVISAKFALKPGNHDSICQEMNRLNHLRKLKQPLEFPSCGSVFKRPPGHFAGQLIMDANLKGHRVGGVEVSKKHAGFMINVADGSAKDYEDLIAHVIRTVEQASGVRLEPEVRIIGESL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.