PharMolix/UniProtQA huggingface dataset:
Protein: TRM4A_SCHPO
Sequence: MGRKHYSSKKNRSKKGEFVNWDLIERKNENFEKYYRLQKLVTEDDFILLKQKLTEQLPTTFRITASIPHATQVRDYFIEHYYPLIENARTEDAKIPLPVSLPWYPDGMAFMLDISKEVIRKSPHLKALQEFLVLETEAGDINRQESVSMVPPLLLNVESHHKVLDMCAAPGSKTAQLLEALHKPTKKEDITTLLPSGIVIANDSDNKRAHMLVHQIKRLNSPNVLIVNHDASFLPNFHLSSPDGKKFLKFDRILADVPCSGDGTFRKNIALWNEWSLKTALGLHATQIKILMRGLQLLEKGGRLVYSTCSLNPIENEAVVSAVLNATRGSVRLVDVSSELPQLKRSQGVDNWVVCDSDLNIYPSFDTLPKELYEKMPPTLWPLPKKELAELNIQNCLRIYPHFQNTGGFFVAVLEKYENLTSSMKTAVDDNKVFLREQKLPSEQASKKRKQDTQETSSDSKLAEVKPKGKNGGNRFHELDPFVYIKEDDQALEKIYKKFGIDEAIIKKNQFFVRNVNGVPTKAIYISNDLFRNVIENNRNRVKFVHGGLKIFVRQDFGSLSREIAEKNGTCVFRVQSDGANLASHFIAESCLFHTTLSDLFILLDHEAVTIDDFPEDSLFRKEYNHLDLGSTLLHVDLAKEESVIKKQVYIPLWKSVRICNVLLSNSEKRTLKLQIEGPQSSIHKHNT
What is the function of this protein?
tRNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in tRNAs at position 34 and 48 (PubMed:30646830).  Trm4a and trm4b methylate different sets of tRNAs (PubMed:30646830).  Also methylates cytosine to m5C at positions (60, 61 and 62) in tRNA(Asp) (PubMed:23074192).
What are the official names of this protein?
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4a, tRNA (cytosine-5-)-methyltransferase trm4a.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RPOC_NEIM0
Sequence: MNLLNLFNPLQTAGMEEEFDAIKIGIASPETIRSWSYGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECLCGKYKRLKFKGVTCEKCGVEVTLSKVRRERMGHIELAAPVAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAFVVTDPGMTPLQRRQLLTEDDYYNKLDEYGDDFDAKMGAEGIRELLRTLNVAGEIEILRQELESTGSDTKIKKIAKRLKVLEAFHRSGMKLEWMIMDVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELHAPDIIVRNEKRMLQEAVDSLLDNGRRGKAMTGANKRPLKSLADMIKGKGGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIFHKLEKQGLASTVKAAKKLVEQEVPEVWDILEEVIREHPIMLNRAPTLHRLGIQAFEPILIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQMEARTLMLASNNVLSPANGEPIIVPSQDIVLGLYYMTRDRINAKGEGSLFADVKEVHRAYHTKQVELGTKITVRLREWVKNEAGEFEPVVNRYETTVGRALLSEILPKGLPFEYVNKALKKKEISKLINASFRLCGLRDTVIFADHLMYTGFGFAAKGGISIAVDDMEIPKEKAALLAEANAEVKEIEDQYRQGLVTNGERYNKVVDIWGRAGDKIAKAMMDNLSKQKVIDRAGNEVDQESFNSIYMMADSGARGSAAQIKQLSGMRGLMAKPDGSIIETPITSNFREGLTVLQYFIATHGARKGLADTALKTANSGYLTRRLVDVTQDLVVVEDDCGTSDGFVMKAVVQGGDVIEALRDRILGRVTASDVVDPSSGETLVEAGTLLTEKLVDMIDQSGVDEVKVRTPITCKTRHGLCAHCYGRDLARGKLVNAGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAASQVEAKSNGTARFSSQMRYVANNKGELVVIGRSCEVVIHDDIGRERERHKVPYGAILLVQDGMAIKAGQTLATWDPHTRPMITEHAGMVKFENVEEGVTVAKQTDDVTGLSTLVVIDGKRRSSSASKLLRPTVKLLDENGVEICIPGTSTPVSMAFPVGAVITVREGQEIGKGDVLARIPQASSKTRDITGGLPRVAELFEARVPKDAGMLAEITGTVSFGKETKGKQRLIVTDVDGVAYETLISKEKQILVHDGQVVNRGETIVDGAVDPHDILRLQGIEALARYIVQEVQEVYRLQGVKISDKHIEVIIRQMLRRVNIADAGETGFITGEQVERGDVMLANEKALEEGKEPARYENVLLGITKASLSTDSFISAASFQETTRVLTEAAIMGKQDELRGLKENVIVGRLIPAGTGLTYHRSRHQQWQEVEQETAETQVTDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: SECA_PHYAS
Sequence: MFKFLKKIFNSSKKALRKARVIANKVQNLTETMSLLKDQDFVVKTNELKQRYQKGETLNQLLPEAYALVREATKRVTGLTPYYVQILGAIILHQGNIAEMKTGEGKTLTAIMPAYLNALSGDPVHIVTVNEYLAKREFEGKIGEVFLFLGLSVGINIKDNNTEEKQKAYLCDVLYTTNSELGFDYLRDNMEIDANNLVMKRPYSYAIIDEVDSILIDEARTPLIISQSAKETKNLYKEANRFVKTLKSKHYLIELESKTIELTEEGINKAESFFQIKNLYDVQHSSLLHHIKNALKAFFTMHKNKDYLVNQNQVLIIDQFTGRVLKGRQFSDGLHQALEAKEGVLIKEETSIGATITYQNFFRLYHKLSGMTGTAKTEEDEFRDIYNMEVIEIPTNLPMIRVDEPDFIFVTIQEKYDALIKTTLERHKLGQPILIGTTTVEVSEIISKKLAKNFIKHEILNAKNHFKEAEIIAKAGLKNSVTIATNMAGRGTDIRLGEGVADLGGLAVLGTERHESRRIDNQLRGRAGRQGDPGYSRFFISSEDELAQRFGGKRIEKIISLLQQINTSGKETSSKMVTNFFTKIQKKVESSNFDYRKYLLKYDDILRIQREIIYDQRKGILNSPHPEKIALNLMEKTINQAVVPFFTNTKKTNQPEELILFLEKSFFPKGTFDLKEVQAIFEQSPNTALTEFRKYLSNKMTVILEQQKDSFEKENNDINFFDQVIRWFMLKIIDNYYKRHINDMSVLRQGVGFVGYGQQDSFIEYQKEGQILFNKMVDQIVMDITTAILRFPLPQSFQTPPQQEKMILNDNNSDNNITKRRRKVRISKKPWN
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: PHAE_HALMA
Sequence: MSNTNNIQEEWTEMVEEMNNAVADSMEQNMKAQAAFVESWADAVEDTIPEQDDLADGMDGYNRAYEEWMDAAEQMVERSTDAAQGEDVDPAEFRDIWLQSANEAFKHVMGTSAFAAANGQLVESMMEMQQEADDLSQDTLEQLGFPTRNDVDEIAERLIELERRQHAVEQKLDRVLEHLEE
What is the function of this protein?
Involved in the production of polyhydroxyalkonic acids (PHAs), which are water-insoluble biopolymers used as intracellular energy reserve material when cells grow under conditions of nutrient limitation.  PHAs are composed primarily of 3-hydroxybutyric acid (3HB) and 3-hydroxyvaleric acid (3HV).  Required for the production of poly-beta-hydroxybutyrate (PHB) and poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV).
What are the official names of this protein?
Poly(3-hydroxyalkanoate) polymerase subunit PhaE, PHA polymerase, PHB synthase, Poly(3-hydroxybutyrate) polymerase subunit PhaE, PHB polymerase, Polyhydroxyalkanoic acid synthase subunit PhaE, PHA synthase.
What is the protein family that this protein belongs to?
Belongs to the PHA/PHB synthase family.
Protein: VME1_CVBQ
Sequence: MSSVTTPAPVYTWTADEAIKFLKEWNFSLGIILLFITIILQFGYTSRSMFVYVIKMIILWLMWPLTIILTIFNCVYALNNVYLGFSIVFTIVAIIMWIVYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGRMYVRPIIEDYHTLTVTIIRGHLYMQGIKLGTGYSLSDLPAYVTVAKVSHLLTYKRGFLDKIGDTSGFAVYVKSKVGNYRLPSTQKGSGMDTALLRNNI
What is the function of this protein?
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
What are the official names of this protein?
Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses M protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.
Protein: VSI4_TRYBB
Sequence: MVYRNILQLSVLKVLLIVLIVEATHFGVKYELWQPECELTAELRKTAGVAKMKVNSDLNSFKTLELTKMKLLTFAAKFPESKEALTLRALEAALNTDLRALRDNIANGIDRAVRATAYASEAAGALFSGIQTLHDATDGTTYCLSASGQGSNGNAAMASQGCKPLALPELLTEDSYNTDVISDKGFPKISPLTNAQGQGKSGECGLFQAASGAQATNTGVQFSGGSRINLGLGAIVASAAQQPTRPDLSDFSGTARNQADTLYGKAHASITELLQLAQGPKPGQTEVETMKLLAQKTAALDSIKFQLAASTGKKTSDYKEDENLKTEYFGKTESNIEALWNKVKEEKVKGADPEDPSKESKISDLNTEEQLQRVLDYYAVATMLKLAKQAEDIAKLETEIADQRGKSPEAECNKITEEPKCSEEKICSWHKEVKAGEKNCQFNSTKASKSGVPVTQTQTAGADTTAEKCKGKGEKDCKSPDCKWEGGTCKDSSILANKQFALSVASAAFVALLF
What is the function of this protein?
VSG forms a coat on the surface of the parasite.  The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
What are the official names of this protein?
Variant surface glycoprotein ILTAT 1.24, VSG.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=A soluble form is released from ruptured cells by the action of a PI-PLC.
Protein: MURA_JANMA
Sequence: MDKLLIQGGHRLSGEIAISGAKNAALPILCAGLLTADTVQLSNVPNLQDVTTILRLLRQMGLRAEQDGDKVVLNGSAIDKLEAPYEMVKTMRASILVLGPLLARFGEAKVSLPGGCAIGSRPVDQHIKGLQAMGAEVTIEAGYIHAKAKKLKGTRIVTDMITVTGTENLLMAATLADGETILENAAREPEVTDLANLLVAMGAKIEGIGTDRLVIQGVERLHGATHAVIADRIETATFMCAVATVGGDVTLRNARTDTLDVAFDKLREAGAILTSGDDWIRVQMASRPKAVSFRTTEYPGFPTDMQAQFMAMNCVAEGSSRVIETIFENRFMHVQEMNRLGAAITIEGHTAIINGVDKLVGAPVMATDLRASASLVIAALAAEGETLIDRIYHLDRGYDRMEVKLSAVGAQIQRVK
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIGL1_RAT
Sequence: METSSSRSVQVDDWQKNYSVVASSICTPKQKADAYRALLLHIQDAYANSEISQVFATNLFKRYTEKYSAIIDSDNVVTGLNNYAESIFALAGSQQADSDKWQSGLSINNVFKMSTVQEMMQAGQKFKESLLEPADASVVMCKEPTIFEVPQLGVCGGSEEADLLSSSVHGTEKTQAIPGNSLRCSPFQSTLFPMATNTKTCLTSSAPSGESTTATFHRTPLFGNTKKEPQSFPKTSTGLNMFLSNPSCVPSGCENPRERKAFNDSDTINMLSNPTLNKAPSKTEDSGQREDNSLPTFKTAKEQLWADQKKRSHQSQHTSKSFNGAIKKSLGAGRSRGIFGKFVPPVSNKQDGSEQNGNVKPKSSRAGSAEPAHLTDDRLKNVEPRMVELIMNEIMDHGPPVHWEDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVVNLMSKEQCCLTDEETELVVQQSDGFSGADMTQLCREASLGPIRSLHTADIATISPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFGCGK
What is the function of this protein?
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR).  Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner.  May regulate osteoblast proliferation and differentiation (By similarity).  May play a role in the control of male meiosis dynamic (By similarity).
What are the official names of this protein?
Fidgetin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage- induced foci after ionizing radiation (IR) treatment.
Protein: CFAH_MOUSE
Sequence: MRLSARIIWLILWTVCAAEDCKGPPPRENSEILSGSWSEQLYPEGTQATYKCRPGYRTLGTIVKVCKNGKWVASNPSRICRKKPCGHPGDTPFGSFRLAVGSQFEFGAKVVYTCDDGYQLLGEIDYRECGADGWINDIPLCEVVKCLPVTELENGRIVSGAAETDQEYYFGQVVRFECNSGFKIEGHKEIHCSENGLWSNEKPRCVEILCTPPRVENGDGINVKPVYKENERYHYKCKHGYVPKERGDAVCTGSGWSSQPFCEEKRCSPPYILNGIYTPHRIIHRSDDEIRYECNYGFYPVTGSTVSKCTPTGWIPVPRCTLKPCEFPQFKYGRLYYEESLRPNFPVSIGNKYSYKCDNGFSPPSGYSWDYLRCTAQGWEPEVPCVRKCVFHYVENGDSAYWEKVYVQGQSLKVQCYNGYSLQNGQDTMTCTENGWSPPPKCIRIKTCSASDIHIDNGFLSESSSIYALNRETSYRCKQGYVTNTGEISGSITCLQNGWSPQPSCIKSCDMPVFENSITKNTRTWFKLNDKLDYECLVGFENEYKHTKGSITCTYYGWSDTPSCYERECSVPTLDRKLVVSPRKEKYRVGDLLEFSCHSGHRVGPDSVQCYHFGWSPGFPTCKGQVASCAPPLEILNGEINGAKKVEYSHGEVVKYDCKPRFLLKGPNKIQCVDGNWTTLPVCIEEERTCGDIPELEHGSAKCSVPPYHHGDSVEFICEENFTMIGHGSVSCISGKWTQLPKCVATDQLEKCRVLKSTGIEAIKPKLTEFTHNSTMDYKCRDKQEYERSICINGKWDPEPNCTSKTSCPPPPQIPNTQVIETTVKYLDGEKLSVLCQDNYLTQDSEEMVCKDGRWQSLPRCIEKIPCSQPPTIEHGSINLPRSSEERRDSIESSSHEHGTTFSYVCDDGFRIPEENRITCYMGKWSTPPRCVGLPCGPPPSIPLGTVSLELESYQHGEEVTYHCSTGFGIDGPAFIICEGGKWSDPPKCIKTDCDVLPTVKNAIIRGKSKKSYRTGEQVTFRCQSPYQMNGSDTVTCVNSRWIGQPVCKDNSCVDPPHVPNATIVTRTKNKYLHGDRVRYECNKPLELFGQVEVMCENGIWTEKPKCRDSTGKCGPPPPIDNGDITSLSLPVYEPLSSVEYQCQKYYLLKGKKTITCRNGKWSEPPTCLHACVIPENIMESHNIILKWRHTEKIYSHSGEDIEFGCKYGYYKARDSPPFRTKCINGTINYPTCV
What is the function of this protein?
Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation.  Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces.  Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop.  As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b.  In addition, mediates several cellular responses through interaction with specific receptors.  For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens.  In turn, these pathogens are phagocytosed and destroyed.
What are the official names of this protein?
Complement factor H, Protein beta-1-H.
What are the subcellular locations of this protein?
Secreted.
Protein: GSA_METB6
Sequence: MKSEELFSQAKELMPGGVSSPVRAIKPYPFYTAHAQGAHITTVDGEDLIDCCMAYGPLLLGHAHPEIKKAIAAQLEKGWLYGTPTPYEPEFARLITGDHPGMEMARFVSSGSEATMAAIRLARGFTGKSDIIKIEGGFHGAHDAVLVKAGSGATTMGVPDSAGVLPALVAHTRQLPYNDAEALEAMLASHHDIAALIIEPVLGNIGPVLPEDHYLREIREITSAYGVLLIFDEVITGYRLGIGGAQRMFGVKPDLTTLGKIIGGGLPIGAFCGRKEIMSLVAPQGPVYQAGTFSGNPLSLAAGIATIRWLHDHPGIYPDLAEKARAIGDSIGGGAGGSFVRIGSMFKYFFRDSAPKNYTEVKECDTAAFGRFWEKMRARGIFLPPSQFETNFLSAAHTSDDLATLAGGYTACL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_METPP
Sequence: MSKDDVIQMQGEILENLPNATFRVKLENGHVVLGHISGKMRMHYIRILPGDKVTVELTPYDLSRARIVFRAK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRGB_STAAS
Sequence: MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKTYKIGGDIIYFFLEPATICFAIPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQFANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILNGVIIYALGNKFLKLFRITNPIARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB.  The LrgAB and CidAB proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. LrgB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 3L23_HYDHA
Sequence: MKTLLLTLVVVTIVCLDLGDSLSCYLGYKRSQTCPPGEKVCFVKSWCDAFCGSRGKRIEMGCAATCPTVKDGIDITCCATDNCNTYANWGSG
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Alpha-elapitoxin-Lh2a, Alpha-EPTX-Lh2a, Long neurotoxin 3.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BCA2_YEAST
Sequence: MTLAPLDASKVKITTTQHASKPKPNSELVFGKSFTDHMLTAEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDKCLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNNNITEVGTMNAFFVFKDSKTGKKELVTAPLDGTILEGVTRDSILNLAKERLEPSEWTISERYFTIGEVTERSKNGELLEAFGSGTAAIVSPIKEIGWKGEQINIPLLPGEQTGPLAKEVAQWINGIQYGETEHGNWSRVVTDLN
What is the function of this protein?
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.  Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as well as lysine and proline as the amino donors.  Involved in cell cycle regulation.
What are the official names of this protein?
Branched-chain-amino-acid aminotransferase, cytosolic, BCAT, Protein TWT2.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYTC2_BOVIN
Sequence: MAAEALAAEAVASRLARQEEDIRWLWAEVHRLRDEQLNAPDRCQAEGPCLTREVAQLRAENRELRHCLYRLRLCLAEELSHQARLESAARAEAGRAAAGAQPPPSQSLEEDVKKEIDPDNEVKNPPNFMKERLKFFEILKKDHQLLLAIYEKKGDSSNVITVRVADGRTVKGEAWKTTPYQVAAEISQELAETTVVAKVNGELWDLDRPLEGDATVELLTFEDEEARAVYWHSSAHVLGEALELHYGGLLCCSPPGDGSFHYDVYLEDRAVSSAELPVLESMCQAIIKEQQPFERLEVSTKVLLDLFKYNKFKCRILKEKVATPTTTVYRCGPLVELCKGPHVRHTGTIKVIKIFKNSLAYWADNPEMEMLQRVYGVSFPDEQRMAAWEELQEEARARDHRTIGKEQELFFFHDLSPGSCFFLPRGACIYNTLIDFIREQHHQRNFTEVLSPNMYSCKLWEASGHWQHYSENMFTFDIDKDTFALKPMNCPGHCLMFAHRPRSWREMPIRLADFGVLHRNEPSGALSGLTCVRRFQQDDAHIFCTVGQLEEEIKGCLQFLQSVYSTFGFSFQLNLSTRPENFLGKIELWDEAEKQLQNSLMEFGKPWKINPGEGAFYGPKIDLEIKDALGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKNPVIIHQAILGSVERMIAILSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQWLEKRKRQIML
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
What are the official names of this protein?
Threonine--tRNA ligase 2, cytoplasmic, Threonyl-tRNA synthetase, ThrRS, Threonyl-tRNA synthetase protein 3.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Also detected at lower levels in the nucleus.
Protein: PDAD_PYRAB
Sequence: MSWTTPKKAIMLAAAAEGGTKLNAFDNALLKMGIGNVNLVKLSSVIPAHIEWLDELPKNIPIGMLLPTVYAHIESDEPGSTISAALGVGLSENNEGGLIYEYAGYCTKEEAEEMVRKMVEEGFKVRGWKLKEIKVISAEITVKDKPAAAVAAVVMFPY
What are the official names of this protein?
Pyruvoyl-dependent arginine decarboxylase, PvlArgDC.
What is the protein family that this protein belongs to?
Belongs to the PdaD family.
Protein: ASTER_BOVIN
Sequence: MSANNMSDPRRPNKVLRYKPPPSECNPALDDPTPDYMNLLGMIFSMCGLMLKLKWCAWVAVYCSFISFANSRSSEDTKQMMSSFMLSISAVVMSYLQNPQPMTPPW
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity).  Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein.  Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity).
What are the official names of this protein?
PAT complex subunit Asterix, Protein WDR83OS homolog, Protein associated with the ER translocon of 10kDa, PAT-10, PAT10.
What is the protein family that this protein belongs to?
Belongs to the Asterix family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: OLEO2_BRANA
Sequence: RRDQYPRDRDQYSMIGRDRDKYSMIGRDRDQYNMYGRDYSKSRQIAKAVTAVTAGGSLLVLSSLTLVGTVIALTVATPLLVIFSPILVPALITVALLITGFLSSGGFGIAAITVFSWIYKYATGEHPQGSDKLDSARMKLGGKVQDMKDRAQYYGQQQTGGEDDRDRTRGTQHTT
What is the function of this protein?
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil.  Probably interacts with both lipid and phospholipid moieties of lipid bodies.  May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
What are the official names of this protein?
Major oleosin NAP-II.
What is the protein family that this protein belongs to?
Belongs to the oleosin family.
What are the subcellular locations of this protein?
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface.
Protein: TRKA_HALED
Sequence: MKIIILGAGQVGGTLAEHLAREENDITVVDTDADRLRELHTRLDIRTVAGAGSYPMVLRQAGCEDADMLIAVTNTDEVNMIACQVAHTLFRTPTKIARVRATAYLTRKGLFAHEAVPIDVLISPEQVVTDHIRRLIEHPGALQVLEFTGGLVQLVAVKAYYGGPLVGQELGFLRRHMPSVDTRVAAIYRRNRPIIPRGDTVIEADDEVFFIAARRDIRAVMSELRRLERDFRRVVIVGGGNIGERLAEHLEHSHQVKIVEHNLERCTQLSERLDRTVVLHGSATSKRLLEEENIEDCDIFCALTNDDEVNIMSSMLAKRMGAKKVLTLINNAAYVDLVQGGEIDIAISPQQATIGSLLTHVRRGDIVNVHSLRRGAAEAIEAIAHGDTQSSKVVGRAIGDIDLPSGTTIGAVVRGKEVLIAHDDVVVESGDHVILFVIDKRRIRDVERLFQVGLTFF
What is the function of this protein?
Part of a potassium transport system.  Required for the activity of the TrkH and TrkI transport systems.
What are the official names of this protein?
Trk system potassium uptake protein TrkA, K(+)-uptake protein TrkA.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: KU80_YARLI
Sequence: MASKEATVYVVDLHESMGREMARGHDSKEVTDLNWGLQYIYSEISNKILSGRKTDVVGLVGVHTDTTQNMFEEESGFEHIDIITPIQQFNLDTLLEAKKQLVPNSDNKGDLISGIVVAVQMIKLYTKALKYIRNIVVLTNGQGNMNLGDSGGIIKQLNENRIILKVMGVDFDDEEVDYFEEDKPEHKRENELKLKEFVDRCEDSVFATYKEARDSLDIPKVKAVNPVRAFQGNLVLSDPEQQPPQRVMSIGVEVFPCTRRATAMTASSYAMSKIEPATISTPSQNNLQAVKWDRQYYVNDESGIGGKKELDRDTLENGYRYGSEIVYITKEEEEAIMFPTSASLQVIGFVNKKSVPPYMLMGHTDYIIGQRGNNRDAVAISAFARALFETDNFGLARYVNKDGKDPQIVVLMPYIRAELEGLVFCQLPFAEDERKFILPSLTSLETRSGNKTVTTHSRLLPTKEMLDAMDDYVDAMDLSKLKGEDDEPWLTMEECFNPSIHHIRNVVKECAVSQDYGKIPEPLPILTRFSQPAEELTEEAKPQLELLKHLFDIKEQFREAKKRKTEVTVGQTGLDLDALLEGELEVKLESSQTLSSNVKSEPGRQTASQSSQNSQQLSLDPENICPDFIRTLNKIDTKATSDEEFRSGATNLYKQTITLLEEKLESSKGNDAYNEIIGVLQTMREQADEMEIPDVFTAAKGQFVSKLERGDLGGQKNVLVAQINSI
What is the function of this protein?
Single-stranded DNA-dependent ATP-dependent helicase.  Involved in non-homologous end joining (NHEJ) DNA double strand break repair.  DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA.  Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection.  Required also for telomere recombination to repair telomeric ends in the absence of telomerase.  KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase.  Involved in telomere maintenance.  Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement.  Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere.  Required for mating-type switching (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase II subunit 2, ATP-dependent DNA helicase II subunit Ku80.
What is the protein family that this protein belongs to?
Belongs to the ku80 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.