PharMolix/UniProtQA huggingface dataset:
Protein: DEOC_PECCP
Sequence: MTDYARYIDHTLLAANATEQQIIALCDEAVAHRFYAVCVNSGYVPLVAEKLKGTDVQVCSVIGFPLGAGLTASKAFEAKAAIDAGAQEIDMVINVGWLKSGKIAAVQADIQAVREVCAAIPLKVILETCLLDDEQIVLVCEMCRQLDVAFVKTSTGFSTGGAREEHVRLMRNTVGSEMGVKASGAVRDRQTAQRMIEAGATRIGTSSGVAIVSGEAAAAGNY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPY1_CONBE
Sequence: TVSDPPARPAVFHSREELMNYVRELNRYFAIVGRPRF
What is the function of this protein?
Causes hyperactivity such as jumping, rapid circling and tail flicking, when intraventricularly injected into mice brain.
What are the official names of this protein?
Neuropeptide Y1-like conopeptide, Cono-NPY1, NPY1-like conopeptide.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: NTPPA_THEGJ
Sequence: MLVLASASPRRREILSRFIRDFHVVPSNAEERCSGTPEECAVELARLKAREVYSRVGGTVIGADTVVSIDGRVLGKPSDEGEAYRMLKLLSGRVHRVTTGYCIIHEGKEIAGSATTEVKFRELDDELIWAYIRTGEPMDKAGAYGIQGKAGLFVEWIRGDYYNVVGFPMEIIWKLRELGFEVLSR
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CINA_STRMU
Sequence: MKSEIIAVGTEILTGQIVNTNSQFLSEKFAELGIDVYFQTAVGDNEERLLSVLKIAKERSDLIVLCGGLGPTEDDLTKQTLAKFLKRELVFDKTAQERLDEFFASRPTSMRTPNNECQAQIIAGSQPLSNKTGLAVGGLLEADGVTYVVLPGPPSELKPMVNKELLPYLSKTSEKLYSRVLRFFGIGESHLVTLLHDLIAEQTDPTIAPYAKTGEVTIRLSTKAHRQKEADSKLDKLEKKIITIDNLADYFYGYGEENSLPQVVFDLLKEKGKTITAAESLTAGLFQARLADFAGASDIFKGGFITYSIEEKARMLGIPFEDLQLHGVVSAFTAEKMAERSRQLTQADLAISLTGVAGPDSLEGQPAGTVFIGLSSSKRTMAIKVLIGGRSRSDVRYIAVLHAFNLVRQTLLSHKNLV
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: UPPS_SULTO
Sequence: MFKEKVGKIILYPVYKFYEKILWNEIKNGPFPQHVGIIPDGNRRWARANNLSINDAYYSGYRKLKQVLLWLLEMGIKNITVFALSTENCDKRSNLELNTIFNYIKAGLEELLYGEIIYKYEVKVRAIGLIYKLPLDLLEVLNQLSKKTENFNKRKLTLAICYGGRQEIIDATKKIIADYEKGKIKLDDINENIFRQYLYDKELEDIDLVIRSSGEIRISNFLLWHIAYSELFFVDTYWPDFRKIDLWRAIRSYQKRKRNFGA
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP).  It is probably the precursor of glycosyl carrier lipids.
What are the official names of this protein?
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific), Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: TGT_SHEB8
Sequence: MKFELDTTDGRARRGRLIFDRGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFLDPEKSMQIQDALGSDVVMIFDECTPYPATEDEARKSMQMSLRWARRSRDEFDRLENPNSLFGIIQGGVYEDLRDESLKGLVDIGFDGYAVGGLAVGEPKADMHRILEHICPQIPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTSPLDTKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQMLMEGLRGAIETGTLDAFVADFYTSQGREVPELVN
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NUOI_POLSJ
Sequence: MSTVASVKDFVSSFMLTELFKGMALTGKYMFSRKITVQFPEEKTPLSPRFRGLHALRRYDNGEERCIACKLCEAVCPALAITIESEVRDDGSRRTSRYDIDLTKCIFCGFCEEACPVDAIVETHIFEYHGEKRGDLYFTKEMLLAVGDRYEAEIAANKAADAKYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: URK_MYCPN
Sequence: MDSKKGILVAIGGGSCSGKTTIADMIYQLLRKKLKVAILPQDNYYKPYKNKSMAQRKAINFDHPDAFDWKLLWSHLDNLLMGKTVAVPMYDYVNYTRKKETIEIGPLNVVILEGLMPWFDERIAKLCKLKIFVEATGEERLIRRIERDWERGRDVASIIKQWREAVSPMYEIFVEKMKQKADLIIPWSERHEVSTNVLDFAIEHLFRKHVDPN
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_CHLCV
Sequence: MEEDFFKLILITDRQNIPMEEYLDFVSACVQSGVTAVQLREKGLSHRELLSFGGALKSILDPLDIPLIVSDSVSVCLDLDASGVHLGQTDGDVIEARELLGPDKIIGWNVHTLDQLLNANTLPIDYLGLSALFATENKPEATDLWGFSGLEQAVSLCEHPIVAVGGIDESNAGNVVEAGAAGIAAIGAFHSAHNPGLATKALREIVDRGLRC
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: PHP4_SCHPO
Sequence: MESSKSPSEVEKSSSASPAPQKPMIRVSKQWVVPPRPKPGRKPALDALGRRKAPIKPRPGPTSALSVEEAKFRVREKQYQDTIGKLQKENNELLEQLEMLQAQLKNSTLDSPKEVEVNSEVVKPDSATTENENRYVNQYNYPVEPPCAKNAVYTEIPIELDPHAFLGDSAKRIRVDSDSKDAKSVPSENGRIRVSMSPQNEINFTPENPAVMEKIRKRGVCNSVEGCLYSGSPKSVKRVRESEETKVYAQLLIDLHKSSKSAPMLKAGPSIAFKLPTMEPNFNDVRPVTSISSSS
What is the function of this protein?
Component of the transcription regulatory CCAAT-binding complex.  Required for the reprogramming of the cell for iron use.  Down-regulates pcl1, sdh4, and isa1 underlow-iron conditions.
What are the official names of this protein?
CCAAT-binding factor complex subunit php4.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Iron starvation induces nuclear accumulation and iron induces relocalization to the cytoplasm, in association with exportin crm1.
Protein: LAC1_ORYSJ
Sequence: MGTAKIPALLWFLLAGLVLALAVNPAHGAKTRHYDFFITETNYTRLCHEKSILTVNGQFPGPTIYARKGDFIIVNVHNNGNKNITIHWHGVDQPRNPWSDGPEFITQCPIRPGGNFTYQVILFEEEGTLWWHAHSDFDRATVHGAIVIHPKRGTTFLFRKLDKEIPWWNDDVEHVLDKAKRIGGDVEPSDTNTINGQPGDMFPLCSRDDTFKVAVQQGNTYLLRVINAGLTNDMFFAIAGHRLTVVGIDARYTKPITVDYIMIAPGQTMDVLLKANRTLGSNSRYYMAARTFITLPVDTIRFNNSTATAIVEYTDSAVARPVGPPEFPVLLPAIKDEDAAMAFVKQLRSLGNQDHPVHVPKQVDEHMLIDIDINFLPCDANNATNKLCEGPQGNRFAASLNNVSFQNPAIDVLDAYYYGSGRGVYEENFPNKLTVIVNPTGDINGGGPLLTKRGTKVKVLEYGTVVEVVFQDLSIENHPMHLHGFTFYVVGRGSGTFDERRDPATYNLIDPPFQNTVSVPKSSWAAIRFRADNPGVWFMHCHFDRHVVWGMDTMFIVKDGKTPQAQMLPRPPNMPEC
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products.
What are the official names of this protein?
Putative laccase-1, Benzenediol:oxygen oxidoreductase 1, Diphenol oxidase 1, Urishiol oxidase 1.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: MNMA_RHIL3
Sequence: MTQAELAPSLNTLDFDKKPEETRVVVAMSGGVDSSVVAGLLKQQGYDVLGITLQLYDHGAAVHRAGSCCAGQDIDDARRVCETLGIPHYVLDYEKRFRETVINPFAESYVAGETPIPCVSCNQTVKFADLLATAKELGADALATGHYIRSGRNPSPENPGRRALFRPADADRDQSYFLFATTQEQIDYLRFPLGGLPKAETRRLAEEMGLVVAKKADSQDICFVPQGKYSDVITKLKPNAALAGEIVHLDGRVLGTHEGILHFTIGQRRGIGIATGEPLYVVFLDARSRRVIVGPKEALETHRVYLRDVNWLGDETLAEAAAGKGFACYAKVRSTRAPAPAVLHIDATGTYVDLTVGEAGIAPGQACALYSAPGDNARVFGGGFIERSEREPSAEACLKALLASPVAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABF_ECO57
Sequence: MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCEDIISRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHTSLMNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAYGDADVMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLVLEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGYVNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRDQAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI
What is the function of this protein?
Involved in the type II fatty acid elongation cycle.  Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor.  Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.
What are the official names of this protein?
3-oxoacyl-[acyl-carrier-protein] synthase 2, 3-oxoacyl-[acyl-carrier-protein] synthase II, Beta-ketoacyl-ACP synthase II, KAS II.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Protein: RECR_ORITB
Sequence: MHKDSNIIEELIFSFAQLPGLGNRSARRIVLYLMQDKEVRIKNLNNQLTSVLNNIMECDYCGNLDVVSICNICRHSERDSSIIAIVESVADLWALERSKVFKGWYHVLGKTLSAVSGNDAINSLKLPKLLNRIREYKVQEIILATNSTIDGQMTAFFVIDYLKDENLKISKLASGIPLGGELDYLDEGTLLAAFKARQSHDLL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: HC3S_ACIFR
Sequence: ANVLWLQGGAXSGNTMSFLNAEEPSAXDLVTDFGINVLXQ
What are the official names of this protein?
Cytochrome c3 hydrogenase small chain, Hydrogenase.
Protein: LRC58_HUMAN
Sequence: MEEAGAAVVTAGEAELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSASHSSTSQSESDSEDEASVAARRMQKVLLG
What are the official names of this protein?
Leucine-rich repeat-containing protein 58.
Protein: DSBI_SALPA
Sequence: MDFIKGLWRDLRARPVDTLVRWQEQRFLWLLMAIAMGGLIILAHSFFQIYLYMAPCEQCVYIRYAMFVMVIGGVIAAINPKNIVLKLIGCIAAFYGSIMGIKFSIKLNGIHHAVHNADPDSLFGVQGCSTDPTFPFNLPLAEWAPEWFKPTGDCGYDAPIVPDGVTLSSVQQWFVDLYQQSEGWYLLPPWHFMNMAQACMLAFGLCLILLLVMSGAWALKLARGK
What is the function of this protein?
Required for disulfide bond formation in some proteins.  Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT.
What are the official names of this protein?
Protein-disulfide oxidoreductase DsbI.
What is the protein family that this protein belongs to?
Belongs to the DsbB family. DsbI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HEM6_BORPD
Sequence: MSAVPVSDVHAYLTGLQDNIVQALEQAGGESFRTDTWQRPEGGGGVSRLIEGGQLLERAGVLFSHVHGTRLPPSASAHRPELAGRSWQAMGVSLVLHPRNPYVPTTHMNVRMFVAAARPGHDENDVFWFGGGLDLTPYYAFEDDARHFHQVCRAALDPHGAAYYPQYKRWCDEYFYLKHRQEMRGVGGVFFDDLNEPGFDASFALLRSVGDAFLPAYLPIVQRRRDTPYTQAQRDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPMAQWRYDWQPAAGSPEAALAGFLQPRDWA
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK35_PHATC
Sequence: MPKLKTRKAAAKRYKRTGTSNFLRRHAFKGHLLMKKSNKQKRKLSQTICVSRSDIKSIKLMLPY
What are the official names of this protein?
50S ribosomal protein L35, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UTP18_MOUSE
Sequence: MPPERKSRTRRDRRAGATPGRKARPGSGSTPAKAARSSQRTQPAEPRAAPSAGSAAAAAEEEESRLRQRNRLTLEDDKPAAERCLEQLVFGDVEDDEDALLQRLRSSRGQLHGSSDESEVENEAKDIFSQKKKQPVWVDEDDEDEEIVDMSNNRFRKDIMKNASESKLSKDKLQKRLKEEFQHAMGGVPDWAEAGSKRRTSSDDESEEDEDDLLQRTGNFISTSTSLPRGILKMKNCRPANAERPTTARISSVQFHPGAQVVMVSGVDNAISLFQVDGKTNPKIQSIYLEKFPIFKACFSANGEEVLATSMHSKVLYVYDMLAGKLIPVHQVRGLKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKINGRIAASTFSSDSKRIYTYSENGEVYVWDVNSRKCMNRFLDEGSLCGLSIAASKNGQYVACGSKSGVVNIYNQDSCLQQTNPKPIKAIMNLVTGVTSLAFNPTTEILAVASRKMKEAVRLVHLPSCTVFSNFPVFKKSTLSRVQTMDFSPRGGYFALGNEKGRALMYRLHHYSDF
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Involved in nucleolar processing of pre-18S ribosomal RNA.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 18 homolog, WD repeat-containing protein 50.
What is the protein family that this protein belongs to?
Belongs to the WD repeat UTP18 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HBB1_ANAMI
Sequence: VKWSDKERAVIISIFAGLDYEDIGPKALSRCLIVYPWTQRYFGSFGNLSTPAAIMGNPKIAAHGIKVLHGLDRGVKNMDNIKDAYTELSILHSETLHVDPDNFKLLADCLTIVVAAKMGCAFTPDTQLAFQKFLAVVVSALGKQYC
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: DDA1_XENLA
Sequence: MADFLKGLPVYNESNFSRFHADSVCKASNRRPSVYLPTREYPSDQIIVTEKTNILLRYLHQQWDKKNAAKKRDQDQLEIGETSAPPRKIARTDSQEMNEDT
What is the function of this protein?
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
What are the official names of this protein?
DET1- and DDB1-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the DDA1 family.
Protein: NDUS6_NEUCR
Sequence: MPTPESAAFLAKKPTVPPTFDGVDYNDTKRLKQAQDAIIREQWVRVMMGRLVREELSKCYYREGVNHLEKCGHLRERYLQLLSENRVQGYLFEQQNHFANQPKQ
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial, Complex I-12kD, CI-12kD.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFS6 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ILVC_MICAN
Sequence: MARMYYDEDANLDLLAGKTIAIIGYGSQGHAHALNLKDSGVNVIVGLYPGSKSAIKAKEAGIPVYDVAEAAKIADWIMILLPDEVQKTIYLNEIAPNLSAGKVLSFAHGFNIHFGQVVPPANVDVVMVAPKGPGHLVRRTYEQGQGVPCLFAVYQDATGQARDRAMAYAKGIGGTRAGVLETTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLIVEGGLAKMRDSISNTAEYGDYTRGPRVVTEATKAEMRKILGEIQSGQFAREFVLENQAGKPGFTAMRRQEAEHSIEEVGQDLRAMMSWLKR
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RS2_TREPA
Sequence: MAVVTIKNLLESGVHFGHQVRRWDPRMKKYIFAERNGIHIIDLQKTITAIREAYDMVRRTVSSGKSVLFVGTKKQSQQTIAKEAQRCGMFYVTNRWLGGMLTNFSTIRKSLSRLKKIERMEIDGTFEHLSKKEVASLRKEHAKLEKNLGGIKEMKELPGVVFIIDTRKETIAIREARRVGIPIVAVVDTNCNPEGIDYPIPGNDDAIRAISLFTQLIANAVMEAGNEHGLKIIENLQDEESGDELDESVSLHEEGREITDYENYTPPEEREYSVNDEGDVFDEDESLYEGR
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SSK22_YEAST
Sequence: MMMDILNTQQQKAAEGGRVLAPHTISSKLVKRLSSHSSHKLSRSDLKALGGSETISDGPSQLTFKDRYVFNESLYLKKLKKTALDDYYTRGIKLTNRYEEDDGDDEIIRLSNGDRIDEDLHSGVKFFSTTPYCRKMRSDSDELAWNEIATERFKWQSMLARVLKGDIVKGEKTRIANQVKKPGLNKELSDEIWLELKAWLNGRTMQEMEQSLTYLRDSSDSVFEEIMKFQIPQGKILSLDALEAILQDLMNRYHSVVSYWPNLKKMYKDKPITNTAEFTARIDVMNSWLNFKTNLTLRRQELDDWINRFSPISSSDNCQEDFDGVPQWNCKMKILAEQLMKEKNIESIFQKKIFYPLSPWMFKLKLHFIVYRETLTKMNIKYPYERLRSLLAFPVYLIKEVILTRLSYARKLKNPTMMMIDQMIDDFNAFIRLSVQLKYTLTKYCSNLPFDVDFDPTFENTVIEAIRYLFFLLNLKLIDSSKQNFKAPDLLLKYWDHLKNTGHYINGAETVIPNEFLKLTLRLVHKLQFYLLKQQNFPPTFANASEAEKWLSSIFENLGAMKRKLNRFSNILVKAFQNSAVYQINHNAQLVKKLKDAHYFLVYSGNTFESSGVYMFAAPELLGCDNDTILRILRNKSIGCDLVPKLDIGNNLNVYDITTKETDLNILVSKGEDSKGIPYYRVVANSSSDLDRHAHQSKKKNFSTDPFDQHLDEKNNEVFELEVALSSLGALVVLYPGEPVVWDGPVYKLPGNNLFASNEMDLGKIGNPNTLILLNQGSNYALTYQIDKFNQTVGDSVSFIEKRCSLNSIESSLQKINKAYYKLTYTVLNNYKGILGSFMKQCPGNELLNSIFMFGRDFGRSFLKYNAFSSKRKYVIIFLMVKLGMNWLKFLVEECDPTDQRTFRWCVLAMDFAMQMTSGYNILALNVKQFQELKERVSVCMSLLISHFDVMGARATEAENGMQQARLNIDTEENIDEEATLEINSRLRLEAIKTLEKTMKRNPRQMGKVLDATDQGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWMIQIREIAFGNSEKDQVPILSS
What is the function of this protein?
Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Activates the PBS2 MAP kinase kinase by phosphorylation.
What are the official names of this protein?
Serine/threonine-protein kinase SSK22, MAP kinase kinase kinase SSK22, Suppressor of sensor kinase 22.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein: FENR_RICCK
Sequence: MYNTDVVIIGAGPVGLFAVFQAGMFGMKCHVIDAQETIGGQCITLYPEKPIYDIPAYPKIVAEELIKQLELQAAPFKPVYHLNQQAIELNKQGDFFEIKTSKNTLIKSKIIIIAAGAGSFGPNKPPLANIEDFEGKSVFYFINDKNKFTGKNIVIAGGGDSAVDWAISLSEIANKIYLVHRRDKFTASPESVRQLRNLAETGKIELVIGYQLNALDGNNGELQSVIVRDLQNNTHKLEANILLPFFGLKQNLGSLANWGLNVKLQHIEVDNSYYQTNIEGIYAIGDIAHYTGKLKLILIGFAEAASSLHHAYSRVFDGKALHFEYSTTKYGKNGKKK
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: STRAP_RAT
Sequence: MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLEPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETAEEELEEIASENSDSIYSSTPEVKA
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.  STRAP plays a role in the cellular distribution of the SMN complex.  Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity).
What are the official names of this protein?
Serine-threonine kinase receptor-associated protein, UNR-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat STRAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.