PharMolix/UniProtQA huggingface dataset:
Protein: UVRC_XANC5
Sequence: MSVRPHNDFDGKAFAAQLSTAPGVYRMYAGDDTLLYVGKAGALRKRVGSYFNGTPKNARLTSMLSQVARMDVTVTRSEAEALLLENQLIKSLSPRYNVSLRDDKSYPYVLLTREQWPRIALHRGPRAVQGRYFGPYTGVTGVRETLSLMHKLFKLRSCEDSVFRNRSRPCLQYQIGRCSGPCVDLVAAPDYAESVRRATMFLEGKSDQLGEEIMHSMQQASEALEFERAARLRDLLSSLRSMQNRQYVDGRAADLDVLACATQSSQACVLLLSFRDGRNLGTRSFFPKTNGEDSADEILGAFVSQYYAEHSPPREILLDREIPEAELIEAALSTAAEHKVALKWNVRGERAGYLLLATRNAQLTLVTELTSQSAQHARSEALREMLGLAEPVKRVECFDISHTMGEATVASCVVFDASGPVRGQYRRFNISGITPGDDYAAMRQAIERRFRRAVEENGVLPDVLLIDGGAGQLAQAQAALADLGVENVLLVGVAKGEERRAGHEALIMADGRELRPGAASPALQFIQQVRDEAHRFAITGHRGRRHKARMTSKLEDIPGIGPRRRASLLKHFGGLVGLKAAGEAEIARVEGVNAALAARIYANLHGLALPDAAGEASPQ
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_BURPS
Sequence: MAKISKRRQAFAAKVDRQKLYPIDDALALVKECASAKFDESIDVAVQLGIDAKKSDQVVRGSVVLPAGTGKSVRVAVFAQGEKAEQARAAGAEVVGMEDLAEQIKAGQMDFDIVIASPDTMRIVGTLGQILGPRGLMPNPKVGTVTPDVATAVKNAKAGQVQFRVDKAGIIHATIGRASFEPTALRTNLSALIEALQKAKPATSKGVYLRKIALSSTMGVGVRVDQGSLAAQ
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CODY_STRP2
Sequence: MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGQLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY
What is the function of this protein?
Target genes are mainly involved in amino acid metabolism, biosynthesis and uptake, but also several other cellular processes, such as carbon metabolism and iron uptake (PubMed:18024519).  Binds to a 15-bp recognition site, the CodY-box (PubMed:18024519).  Additionally, in pathogenic bacteria, CodY also regulates virulence gene expression and provides a regulatory link between metabolism and pathogenesis (PubMed:18024519).
What are the official names of this protein?
Global transcriptional regulator CodY, Global nutritional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_PSEPW
Sequence: MTQSLADMRRDYTRDGLAEAQAPGEPFALFHQWFADAVKTEQPPVEANAMTLATVDGDGRPHCRVLLLKGLDDRGFTFFTNYDSAKGQQLQANPYAAMTFFWPALERQVRIEGRVEKVTPQESDDYYQVRPLGSRLGAWASPQSRVIASREALEGLVKATEARFSDTQPHCPEHWGGYRLLPERIEFWQGRASRLHDRLNYRWVDGQWARERLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RLMG_SHEON
Sequence: MTTQFSVAGIELELFRYPASQESNLQAWDAADEHLINSLIEGGQIAVPTAIINDSFGALSCALSRINPNWPLRVETDARTSFLGTEQNHHRNQLPMDNLQWFTSRDTLPKDVALVLMKLPKNLTYFAHQLMRLSQILPAGCRVLVGAKAKSINSSLLALFAKHLGPANASLAWKKTRVITCISDGKPRALPNGITWNIPEFNLTISNLSNVFAANKLDIGARIMLDNLPQGKFNTVVDLGCGNGVLGLRAAQLYPNADIHFIDDSEMAVASAKANWTMNQLAEGKGHFHWDDCMTHLPEDIEPDLVLCNPPFHQGEAITDHIAWQMFLDARRRLKNGGILHIVGNRHLAYHVKLQRLFKNCTTVASNGKFVILQAQK
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGI_ENTH1
Sequence: MQFEKVTYIAVPQKYGQKKVGVEEGPKFLEKLGFMNVLEQVAKSVNKKTITEPKTPQELGVTNARNLNEVESVNIELRDTIAKEYDVNNLLINIGGDHSIGLGTIAGVVKAMKPNARVGVVWFDAHPDMNTPENSPSGNIHGMPLACAVGLGPQRLTSIMPHYITPKDIMYVGIRSIDVGEQFEIQDKHIDHFTAEDVKRVGMKEVIEAINKKFVDYDVIHLSFDIDGIDPEFILGTGTPVPKGISLEDSLYFMSEMGKMKKLHSVDIVEYNPKIEEEITGKNVLKCISSLFGIKC
What is the function of this protein?
Catalyzes the hydrolysis of L-arginine into urea and L-ornithine, which is a precursor for polyamine biosynthesis (PubMed:15053781, PubMed:29691540, PubMed:31199070).  By depleting host L-arginine, a substrate for nitric oxide synthase (NOS), prevents the production of nitric oxide (NO) by host activated macrophages, and thus allows the parasite to evade host immune response (PubMed:15053781).
What are the official names of this protein?
Arginase, EhArg.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: RS262_ARATH
Sequence: MTFKRRNGGRNKHNRGHVNPIRCSNCGKCCPKDKAIKRFIVRNIVEQAAIRDVQEASVYEGYTLPKLYAKTQYCVSCAIHSHVVRVRSRTNRRVRTPPPRFARRKEDTPKPGQPGQAPRPAGPGAAAAAAPRV
What are the official names of this protein?
40S ribosomal protein S26-2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS26 family.
Protein: QUEC_VIBVU
Sequence: MNKAVVVFSGGQDSTTCLVKALNEFDEVHAITFDYGQRHRLEIEVAQNLAKELGVAAHKVMDVTLLNELAISSLTRDDIPVSHELQENGLPNSFVPGRNILFLTLAGIYAYQIGAQTIITGVCETDFSGYPDCRDDFVKAMNSALVKGMDKPLVIQTPLMWLNKTETWALADQNNALQLVREKTLTCYNGIIGDGCGDCPSCHLRKVGLNDYLDNREAIMASLVEKQHAES
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RLME_ACIB5
Sequence: MATRITNQKLSKSSRAWMREHLDDPFVKKAQKEGYRARAAYKLLEIQEKYKLIKPGMTVVDLGAAPGSWSQIAGKLVGSKGLVIASDILPMDALPDVTFLQGDFREEAVFEKLLNILNGRQVDIVISDMAPNTSGNRAVDQPRQIYLCELALDFAQKVLGPNGQFVVKVFQGAGFDEFRKQVVDSFDVLKTAKPAASRARSKEVFLVGQGRKKALQ
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG159_MONPV
Sequence: MTSILNTLRFLEKTSFYNCNDSITKEKIKIKHKGMLFVFYKPKHSTVVKYLSGGGIYHDDLVVLGKVTINDLKMMLFYMDLSYHGVTSSGAIYKLGSSIDRLSLNRTIVTKVNNNYNNYNNYNNYNCYNNYNCYNYDDTFFDDDD
What are the official names of this protein?
Protein OPG159.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG159 protein family.
Protein: HBG1_PANTR
Sequence: MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH
What is the function of this protein?
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
What are the official names of this protein?
Hemoglobin subunit gamma-1, Gamma-1-globin, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ARY2_MACMU
Sequence: MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENLNMHCGEAMELGLETIFDHIVRRNRGGWCLQVNQLLYWALTTIGFQTTMLGGYVYIPAANKYSTGMIHLLLQVTIDGRNYIADAGFGSSSQMWQPLELISGKDQPQMPSIFRLTEQKGIWYLDQIRREQYIPNTEFLNSDLLPKTTHQKVYSFTLEPRKIEDFESMNTYLQTSPTSAFTTTSFCSLQTPEGVHCLVGFTLTYRIFNYKDNTDLIEFKTLIEEEVEEVLKNIFKISLGRKLVPKPGNGSFTI
What is the function of this protein?
Participates in the detoxification of a plethora of hydrazine and arylamine drugs.  Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens (By similarity).
What are the official names of this protein?
Arylamine N-acetyltransferase 2, Arylamide acetylase 2, N-acetyltransferase type 2, NAT-2, Polymorphic arylamine N-acetyltransferase, PNAT.
What is the protein family that this protein belongs to?
Belongs to the arylamine N-acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSIH_PSICY
Sequence: MIVLLVSLVLAGCIYYANARRVRRSRLPPGPPGIPLPFIGNMFDMPSESPWLRFLQWGRDYHTDILYLNAGGTEIIILNTLDAITDLLEKRGSMYSGRLESTMVNELMGWEFDLGFITYGERWREERRMFAKEFSEKNIRQFRHAQIKAANQLVRQLIKTPDRWSQHIRHQIAAMSLDIGYGIDLAEDDPWIAATQLANEGLAEASVPGSFWVDSFPALKYLPSWLPGAGFKRKAKVWKEGADHMVNMPYETMKKLTVQGLARPSYASARLQAMDPDGDLEHQEHVIRNTATEVNVGGGDTTVSAVSAFILAMVKYPEVQRQVQAELDALTSKGVVPNYDEEDDSLPYLTACVKEIFRWNQIAPLAIPHRLIKDDVYRGYLIPKNALVYANSWAVLNDPEEYPNPSEFRPERYLSSDGKPDPTVRDPRKAAFGYGRRNCPGIHLAQSTVWIAGATLLSVFNIERPVDGNGKPIDIPATFTTGFFRHPEPFQCRFVPRTQEILKSVSG
What is the function of this protein?
Tryptamine 4-monooxygenase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product (PubMed:28763571, PubMed:30283667).  The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD.  PsiD does not decarboxylate phenylalanine, tyrosine, or 5-hydroxy- L -tryptophan (5-HTP) (PubMed:30283667).  4-hydroxy-L-tryptophan is accepted as substrate by psiD as well.  The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine.  The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin.  The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin (By similarity).
What are the official names of this protein?
Tryptamine 4-monooxygenase, Cytochrome P450 monooxygenase psiH, Psilocybin biosynthesis hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: PIM3_HUMAN
Sequence: MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
What is the function of this protein?
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation.  May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity.  Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6.  Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
What are the official names of this protein?
Serine/threonine-protein kinase pim-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYV_PSELT
Sequence: MNLGTRYSPEQIEKKWYERWVEKGYFAPKGSGIPFVIVIPPPNITGRIHMGHALNITLQDILVRYKRMRGFDTLWVPGEDHAGIATQNAVERYLESQGKSREQLGREKFIEIVWEWAKKYRKEIRQQIETLGASVDWSRERFTLDDGLSKAVRKVFVDLYNRGLIYRGKYMVNWCPRCQTVLSDEEVEHIEESAKLYYVKYPFSGSNEYIVIATTRPETMLGDVAVAVNPEDERYKNISGKTVVLPLMNREIPIITDSYVDPEFGTGAVKITPAHDPNDFDIAKRHSLQFIEIFDNEAKINENGGKYAGLDRYQARKAVLEDLEKAGFLLKVENINHAVGHCYRCDSVIEPRIMDQWFVSMKSLSKRAIEAVENEEIRFVPERWKKVYLHWMYNIRDWCISRQLWWGHRVPVWYCKNCNETIVSEIDIEECPKCGSKSIEQDEDVLDTWFSSALWPFSTLGWPEKTEDLEKYYPTSVLVTGFDIIFFWVARMIIMGYQFMQKKPFTDVYIHQLIRDKHGRKMSKSLGNGIDPIDMSEKYGTDPVRFTLAIFAAQGSDIKLDERYFDTYRKFANKIWNAARFVLINLDNYKPQPLNELSLADRWILSKLQKVISVVSDAIEKYEFNIAARSLYEFFWNEFCDWYIESSKLVLNSEKKAITQNVLVKVLDTSLRLLHPFMPFLSEELWQNLPVHGESIVISDWPEVDVTLINEEAEKNFEKLVQIIRGIRNVKAEMNIPPKRNTKVYIYGETLCKEESSYIEHLSGAQISYVKEKPACCATAFVSENQHVYVDVAGLNLQSEIKRLMKNIEKLQKEREWQLKKLSDDKFLSNAPEEAISEARQKLSEIEDRLKILNQILGDLM
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GHRB_ENTAG
Sequence: MKPEVLLYKSLPDDLRARLDEHFTVTAINGLSPETIAEHGGAGARRRHDRLQQHGGSSAAGENAKLRAASTISVGYDNFDVEALNQRGIVLIDTPTVLTETVADTMMALVLSSARRVVEVAERVKAGEWRRSIGPDWFGIDVHHKKMGILGMGRIGLALAQRAHHGFGMPILYNARKHHEEAESRFNAQYCDLDTLLRESDFLCISLPLTEQTHHMIGREQLAKMKPSAILINAGRGPVVDEQALIAALKDKTIHAAGLDVFEQEPLPVDSELLTLPNVVALPHIGSATHETRYGMARDAVDNLIAALAGKVEKNCVNPQVLR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THSA_METTH
Sequence: MAQGQQPIFILPQDTSRYVGREAQRINILAGKVLAETVRTTLGPKGMDKMLVDSLGDIVITNDGVTILREMDISHPAAKMLVEVAKTQEDEVGDGTTTAVIIAGELLKEAEKLIEMGVHPTIIALGYRNAALKAQEILEEISMEASDRDTLMKVAITAMTGKGSERAKEKLAELVVDAVMQVEEDGEIDKDNINIQRIQGASVNESRIVNGIVIDKSRADTSMPKRIEKARIALLKYPIEVKDLETDAKIRLTDPSQMQAFIEQEEQMIRDMVEKIKSSGANVVFCQKGIDDLALHYLSREGIMALKRVKKSDIKRIEKATGARLVTNIDDLTAEDLGEAGVIYEKKIFDEVLTFIEECRDPKAISIILRGSTKHVAEEMERALEDAIGVVASTLEDREVVAGGGAPEVEIARKLREYADTISGREQLAVSAFADALEIVPKTLAENAGLDSIDVLVDLRAAHEESPYMGIDVFDGNIVDMKEAGVIEPQRVKKQAIQSAAEAAEMILRIDDMIAARGFDVSSKDEEDMEGMGGMGGMPPMM
What is the function of this protein?
Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
What are the official names of this protein?
Thermosome subunit alpha, Chaperonin subunit alpha, Thermosome subunit 1.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
Protein: EG15B_MDBVW
Sequence: MYIDTGIMSNNIFLFAFFALVGLTRIEAMPTKGSEGTWNVDYEDQEHTGITCRENEHYNSTRIECEDECNDRNNKLCYRFQQFCWCNEGYIRNSSHICVKLEDCLKDEEQKSETLASSANNDSSKRLEDDLKLFSHDSVSHTSLEPETQAQKFNGIIDQETLDLVFGKPENSSADNKPLETKTQAQKFNGIINEETLDLVFGKPENSWAENKPLETKTQAQKFNGIINEETLDLVFGKPENSWAENKPLETETQAQKFNGIINEETLDLVFGKPENSWAENKPLETKTQAQKFNGIINEETLDLVFGKPENSWAENKPLETKTQTQKFNGIIDQYTRRIVFVFSNI
What is the function of this protein?
Counteracts the host humoral immune response by inhibiting the processing and the amidolytic activity of host PAP1 and PAP3.  Thereby, melanization of host hemolymph, normally producing several reactive intermediates toxic for viruses, is deregulated and proper immune response cannot occur (By similarity).
What are the official names of this protein?
Protease inhibitor Egf1.5b.
What is the protein family that this protein belongs to?
Belongs to the polydnaviridae EGF-like motif protein family.
Protein: MIG21_CAEEL
Sequence: MERDSNTAKSEIFYSNPAIWRHLKDGKGEGMSKSEKRNKHGCRNFTYSIWNCIRPGGWSTWSKWSKCREGIRKRRRTCNNPLPIGTTCSGQKVEKQSCAISSNVPEYLFGSWTSWNPWSRCDCDRSLRIRTRHCKGNSCEGCDKDYEDCRPDECPISKKWSEWTDWVNYGIEQVRFSAWCSSSNVANTEVGIRKETQDSMKHANWSEWHMHPGVAYRYRLLHNSSISIEHHLLSRFTSSCLPLHFAIPIFCFCILTGFLLQNIIYCVVNRFKRRFIRLNYSYDSNPRDYPSHLIRSPGSPKDESFW
What is the function of this protein?
Required for determination of left/right asymmetry in nervous system.  Acts together with unc-40 to control an initial left-right asymmetric polarization of the Q neuroblasts.  Mig-21 and unc-40 may control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the 2 Q neuroblasts.  Involved in left-side QL posterior migration.  In right-side QR, unc-40 and mig-21 pathways mutually inhibit each other in posterior migration, allowing anterior QR migration.
What are the official names of this protein?
Abnormal cell migration protein 21.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CAPSD_BPHK7
Sequence: MSELALIQKAIEESQQKMTQLFDAQKAEIESTGQVSKQLQSDLMKVQEELTKSGTRLFDLEQKLASGAENPGEKKSFSERAAEELIKSWDGKQGTFGAKTFNKSLGSDADSAGSLIQPMQIPGIIMPGLRRLTIRDLLAQGRTSSNALEYVREEVFTNNADVVAEKALKPESDITFSKQTANVKTIAHWVQASRQVMDDAPMLQSYINNRLMYGLALKEEGQLLNGDGTGDNLEGLNKVATAYDTSLNATGDTRADIIAHAIYQVTESEFSASGIVLNPRDWHNIALLKDNEGRYIFGGPQAFTSNIMWGLPVVPTKAQAAGTFTVGGFDMASQVWDRMDATVEVSREDRDNFVKNMLTILCEERLALAHYRPTAIIKGTFSSGS
What is the function of this protein?
Assembles to form an icosahedral capsid of 66 nm, with a T=7 laevo symmetry (PubMed:11000116, PubMed:21276801).  Responsible for its self-assembly into a procapsid.  The phage does not need to encode a separate scaffolfing protein because its capsid protein contains the delta domain that carries that function.
What are the official names of this protein?
Major capsid protein, Gene product 5, gp5, Major head protein.
What is the protein family that this protein belongs to?
Belongs to the HK97 phage major capsid protein family.
What are the subcellular locations of this protein?
Virion. Note=Forms the icosahedral capsid shell which contains 420 major capsid proteins.
Protein: SECE_HALMT
Sequence: MDVKYDLNSYVRVLKLASTPSWQEFSQISKIAGAGIFLVGLLGFIIFAVMSFLPGGV
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE, Protein transport protein Sec61 gamma subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL7_PSEA8
Sequence: MALTNEDIINAVSEMSVMQVVELIKAMEEKFGVTAAAATVAAAGPAAAAAEEQTEFTIVLAEAGDKKVNVIKVVRELTGLGLKEAKAVVDGAPGVVKEGASKEEAEAAKKALEEAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: FEN_METBU
Sequence: MGTDIGDLLLKDTIEIAGLSNKVVAIDAYNTLYQFLSIIRQRDGTPLKDSRGQITSHLSGILYRLTSLIEAGVKPIFVFDGKPPDFKSDTLAKRHEVRESATAKWEDAKAQGLEEEAYKYAQASSKVTREMIDDSVRLLELMGIPYVKAPSEGEAQASYMVQKGDADYIGSQDYDSFLFGAPQVVRNLTITGKRKLPKKNIYVDVKPEVLSLVDSLGELGITRQQLIDIAMCVGTDYNTGLENIGPKRALKLVKEHGDIKVVLKELGKDIEDLDAKRDFFMNPPVTDDYELKWIKPDRAGVIDLLCKKHDFSEERVNKALDRLEANIGGSQSTLDQWF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: CHDC_ALKCK
Sequence: MNEAAKTLDGWYVLHDFRKIDWNSWKTVSASEREQMLNEFEALVSKWEGTEKAGKGSHALYSIVGQKADIMIMLLRPTMEELNEIENAFNKSGLAAYMIPTYSYVSVVELSNYLAGDSDEDPYENPYVRSRLYPELPRWKHVCFYPMDKRREGNDNWYMLPMEERKNLMRSHGMIGRGYAGVVKQIISGSVGFDDWEWGVTLFSDDVLQFKKLVYEMRFDEVSARYGEFGSFYVGNILEKERIPAYFHI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: GDNF_XENLA
Sequence: MKLWAILAVCILLLSSVSSIPLPSNWLAGKKRSHLPDPQEGEDQVFGMDGAVPEDPTANMAPQDQQTYTEIPDDYPDQFDDVLEFIQDTIKRLKRSSNKQPPSRRDRGRQSLAANTQISSKKTVKDRKRKNKGCVLREIHLNVTDLGLGYETKEELKFRYCSGSCNNPETTYDQILKNLTIRKKLVNDKVKQACCRPIAFDDDLSFLDDNLVYHTLKQHSAKKCGCI
What is the function of this protein?
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
What are the official names of this protein?
Glial cell line-derived neurotrophic factor, xGDNF.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family. GDNF subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1586_BRUME
Sequence: MRSTKVIHIVGCHAEGEVGDVIVGGVAPPPGETVWEQSRFIANDETLRNFVLNKPRGGVFRHVNLLVPPKDPRAQMGFIIMEPADTPPMSGSNSICVSTVLLDSGIIAMQEPVTHMVLEAPGGIIEVEAECRNGKAERISVRNVPSFADRLDAPLDVTGLGTIMVDTAYGGDSFVIVDAAQIGMKIEPGQARELAEIGVKITKAANEQLGFRHPERDWRHISFCQITEPVTREGDVLTGVNTVAIRPAKFDRSPTGTGCSARMAVLHAKGQMKAGERFIGKSVLGTEFHCRLDKVLELGGKPAISPIISGRAWVTGTSQLMLDPSDPFPHGYRLSDTWPRDE
What is the function of this protein?
In vitro, catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp) and that of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp), albeit with very low efficiency.  The physiological substrate may be different (PubMed:24980702).  Displays neither proline racemase activity nor t3LHyp dehydratase activity (PubMed:17849014, PubMed:24980702).
What are the official names of this protein?
Protein BMEI1586.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: KAD_YEREN
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQMCTGDMLRAAVKAGSELGLKAKEIMDAGKLVTHELVIALVKERITQDDCRDGFLLHGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVDRIVGRRVHAASGRVYHIKFNPPKVEDKDDVTGEELTIRKDDQEATVRKRLVEYHQQTAPLVSYYRKEADAGNTQYFKLDGTRKVAEVSAELATILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.