PharMolix/UniProtQA huggingface dataset:
Protein: AMPA_PARUW
Sequence: MEFALTLHIEKRKKADVLVLPFWKGTSQPEAAIALHPLKLSLDSVFNTGDFKGKEGETLFLYVEGLVEMRVALLGLGEKNKVSTEALRKSYGCLAKACLGKKLKTLNILMPEFNKTEEDAFIKAITEGLLLPNYVYDRLKSKQEEDDEVTLLQKINFISSNKHVLALAEEVAAICDGVYYTRDLINGNADEITPQYLAKCAQGLSQEYPQIKTTVFDKKRLEKEQMGLLLAVNRGSNLDPTLIIMEYKGNPKSKDHTVIIGKGVTYDTGGLNIKPTGGIETMKCDMSGGAACFGTMLAACHLDLKVNLTAIIPATENSVDAASFKPGDVYRSYLGKTVEMTNSDAEGRLILADALAYASQNLKPSRLIDIATLTGAIEISLGSEASGLMSTDDQLAKSLIQAGENTHERLWRMPLYEGYQEKLKSDIADLKSWNGRSGSSCVAAMFLKNFVGKDIPWAHLDIAGTAYVTEPKKYMPKYASGVGVRLLVEFLKQLSMVKN
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3K_PHANO
Sequence: MGAPYDFAPERPDHIQQILDGLDRYNPETTGVFQDYVMQQCESQTYDCYANLALLKLYQFNPHLSRDETVTNILVKALTMFPSPDFALGLSLLPSHLLAPLNSSAHNPAAGDAPLSEAVQKLNELRNLLEGADYATFWSTLDSDDLYADLIADVSGFEELMRVRIAATVSQAVREVDRSILESWLNLEGSDFEHFVGSVCGWTIEGAKIKVPMNKDNEAKGTVVRENVKFDQFARVIKRAYEQPA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit K, eIF3k, eIF-3 p25.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit K family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_ENTFA
Sequence: MLVPKRVKHRREFRGKMRGEAKGGKEVAFGEWGLQATESHWITNRQIEAARIAMTRYMKRGGKVWIKIFPHKSYTSKAIGVRMGKGKGAPEGWVSPVKRGKIMFEIAGVPEEVAREALRLASHKLPVKTKIVKREEMGGESNEG
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: LONM_MAIZE
Sequence: MLRAAVAAAEELRSPLLRVIGTLRDGRGSVLLGRRVRFCSNSSASDTEAAVAEAEAKAEDASAAEGEADSKASSAIVPTSTNIDDCLSVIALPLPHRPLFPGFYMPINVKDQKLLQALIENRKRSAPYAGAFLVKDEEGTDPNIVTGSDSAKSIDDLKGKDLLKRLHEVGTLAQITSIQGDHVVLLGHRRLRITEMVEEDPLTVKVDHLKEKPYNKDDDVMKATSFEVISTLREVLRTSSLWKDHVQTYTQHIGDFNYQRLADFGAAISGANKLLCQEVLEELDVYKRLKLTLELVKKEMEISKLQQSIAKAIEEKISGDQRRYLLNEQLKAIKKELGLETDDKTALSAKFRERIESKKDKCPPHVLQVIEEELTKLQLLEASSSEFSVTRNYLDWLTVLPWGNYSDENFDVHHAQKILDEDHYGLSDVKERILEFIAVGKLRGTSQGKIICLSGPPGVGKTSIGRSIARALNRQFYRFSVGGLADVAEIKGHRRTYVGAMPGKMVQCLKSVGTANPLVLIDEIDKLGKGHSGDPASALLELLDPEQNVNFLDHYLDVPIDLSKVLFVCTANVIEMIPNPLLDRMEIIAIAGYITDEKMHIARDYLEKNTRQACGIKPEQVEVTDTALLALIENYCREAGVRNLQKQIEKIYRKIALQLVRQGVSNEPDHESVSASVTEESGNGDNTTTKDEILKDPAVEDASVTNNVTNPASEEANEENLTSEAAKEDSTSKGNKGTDGAADKAIEKVVVDSSNLGDFVGKPVFQAERIYEHTPVGVVMGLAWTAMGGSTLYIETKKVEEREGKGALVLTGQLGDVMKESAQIAHTVGRAVLLEKEPDNHFFANSKVHLHVPAGSTPKDGPSAGCTMITSMLSLAMGKPVKKDLAMTGEVTLTGRILPIGGVKEKTIAARRSAIKTLIFPAANKRDFDELASNVKEGLEVHFVDTYSEIYDLAFQSDAGTETS
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix.  May also have a chaperone function in the assembly of inner membrane protein complexes.  Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome.  Binds to mitochondrial DNA in a site-specific manner.
What are the official names of this protein?
Lon protease homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RL35_SYNPW
Sequence: MPKLKTRKAAAKRFKATGTGKFLRRRAFRNHLLDHKSPKLKRHLATKAVVDRTDEDRVALMMPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: MNMC_SALPB
Sequence: MKQYAIQPATLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNRLAERFPVHSHPLFIVAESGFGTGLNFLTLWQAFDSFRSAHPQATLQRLHFISFEKFPLTRDDLALAHQHWPELAPWAEQLQAQWPLPLPGCHRLLLDRGRVTLDLWFGDINELTDQLDATLNQTVDAWFLDGFAPAKNPDMWTPNLFNAMARLARPGATLATFTSAGFVRRGLQEAGFTMQKRKGFGRKREMLCGVMEQHLMPTLSAPWFYRSGSEKRETAIIGGGIASALLSLALLRRGWQVTLYCADDQPAQGASGNRQGALYPLLSKHDAAINRFFPTAFTFARRLYDALPVSFDHDWCGVTQLGWDEKSQQKIAQMLSLALPAELASALNAEEAEQAVGVTTRCGGITYPAGGWLCPEQLTRAVIALATEQGLQTRFRHTLTSLVAQESRWQLRFMSGETASHETVVLANGHQINRFDQTRPLPVYAVGGQVSHIPTTPALSALRQVLCYDGYLTPQNPHNQQHCIGASYHRGDESTVWREEDQRQNRQRLLDCFPDAKWATEVDVSGNSARCGVRCATRDHLPMVGNVPDYHATLTHYADLADNKTSAAPAPVYPGLFMLGALGSRGLCSAPLCAEILAAQMSNEPIPLDASTLAALNPNRLWVRKLLKGKAVK
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUP_MYCPA
Sequence: MAQEQTKRGGGGDDEDDFASSTAAGQERREKLAEDTDDLLDEIDDVLEENAEDFVRAYVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: ORC1_BOVIN
Sequence: MAYYSARLRTRQTYSWVGRPLLDQKLHYQTYKEMSMKREDYSTEIHIQVGQFVLIEGDDDENPYVAKLVELFEDDSELYSKKRARVQWFIRFCEVPVCKQHLLGRKPGTQEIFWYDNPTCNSNISVETIIGSVRVVALAPDEVMPIDLKNKKTFFVKLSWNEKKFKPLPPEVFAQLNKLQEDNHRYQKPMQAKTKSAESPSWTTTEHAVKRIESRHSTSKSRHTASHPVTPRARKRLELSSFPRTPNTRISPAASCASLDSPGRMKRKVAFSEVMSPSKRSLPDGFQTSSPALKAPEKTGEIQHSCTKDAKKTSPDHGMILRARAPALKITETSEERTLTPIGGGRKSSVVPSVILKPEYIKRREGKEPEVQDEAPSTSRIRRKSSVLTLNRIRQQLRFLGNSKSDENDEEFLPAAEISDCDSEEEEASTTPLPRRTPNSVSRNLRSSMKSSLQTPSKTPKKTPEPRTPRDATPRIRSRNLTAQGPTNMLEEARLRLHVAAVPESLPCREQEFQDIYNFVESKLLDQTGGCMYISGVPGTGKTATVHEVICCLQQAAQANEVPPFQYIEVNGMKLTEPHQVYVQILQKLTGKRATANHAAALLAKRFCTQGSSQETTVLLVDELDLLWTQKQDVMYNLFDWPTHKEARLVVLTIANTMDLPERIMMNRVSSRLGLTRMCFQPYTHSQLRQILLSRLRHVKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSCQKPDSPGLVTTAHLLEAIDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQVYIQHVALCRMEGLPYPTMSETMAVCSRLGACRLLLVEPSRNDVLRRVRLNVSQDDVLYALKEE
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent.  The specific DNA sequences that define origins of replication have not been identified yet.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
What are the official names of this protein?
Origin recognition complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the ORC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS1_ECO81
Sequence: MTDNTRLRIAMQKSGRLSDDSRELLARCGIKINLHTQRLIAMAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGEDPRYFTLRRLDFGGCRLSLATPVDEAWDGPLSLNGKRIATSYPHLLKRYLDQKGICFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMEESKQQLIDKLLTRIQGVIQARESKYIMMHAPTERLDEVIALLPGAERPTILPLAGDQQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_NITEU
Sequence: MKHKIRHIHFVGIGGSGMGGIAEVLINLGFQISGSDMHSNSTTRRLQCLGAVIHHTHAAENIQSADAVVISTAIHSDNPEVIAARERRIPVVPRAMMLAELLRLRRGIAIAGTHGKTTTTSLVASILAEAGQDPTFVIGGKLKTVDSHARLGKGEFIVVEADESDASFLYLQPVLTVVTNIDADHMSTYEHDFNRLKQTFVEFIEHLPFYGMAVLCVDDPHVREIISMITRPVTTYGIASEDAQICATNIRHDRCRMHFLAHIGVNGSPRTLEVTLNLPGKHNVLNALAAIAVGNELGVPDEAIVKALATFGGVDRRFQQYGEIPLPDQGSFALIDDYGHHPAEIAATMAAARNAFPGRRLVLAFQPHRYSRTRDLFEDFVRVLSGADVLLLTEVYPAGEEPIIAADSKSLARAIRVQGKIEPIYIEQIDELKATIHTIAQDGDVILIMGAGSIGKSAPDLAEPAMKLTLITG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_AZOVD
Sequence: MSPARNDKPFTLAGRTYASRLLVGTGKYKDLEETRQAIEASGAEIVTVAVRRTNIGQNPGEPNLLDVINPARYTILPNTAGCYTAEEAVRTCRLARELLDGHKLVKLEVLADQKTLFPNVIETLKAAEVLVKDGFDVMVYTSDDPIIARQLAEMGCIAVMPLAGLIGTGLGICNPYNLRIILEEATVPVLVDAGVGTASDATIAMELGCEAVLMNSAIAHAQDPVLMARAMKHAIEAGRLAWLAGRMPKKLYASASSPLEGLIR
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGAT_HUMAN
Sequence: MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
What is the function of this protein?
This protein is the basis of the ABO blood group system.  The histo-blood group ABO involves three carbohydrate antigens: A, B, and H.  A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
What are the official names of this protein?
Histo-blood group ABO system transferase, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, A transferase, Histo-blood group B transferase, B transferase, NAGAT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 6 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Protein: DISA_BACC4
Sequence: MEENKQRVKSIINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPDSSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: RECF_TROWT
Sequence: MQNNLISHINLRNFRNYEYQSISFTDGLNLIRGDNGQGKTNLAEAIYFLSGFGSHRTYKNQPLIKSGEQKAEISAKIQSKYGTRNVYIGISCNSNNILKVDGKPSKLRDLVSVFSCVIFSPEDIDLVKGDPGHRRKYLDDIICRARPMMLDIYSAYDRTLKQRNSLLKSFRKSSCKSDLLDIWTQKLVELGLEIVNARKRLLKILNPKISEFYSKLAGVSSTAELFCQSSDCLIDTFDLLRDREIEEGVTLAGPHRDNVDILLNSCPARSQSSQGESWTLALSMKLSLIELMRETKRLYDPDPVVILDDVFAHLDSYRKQKLAQEVFSYEQTIVTTTDNSDNYRTSQTLVVEEGKVFSENKKG
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_BARQU
Sequence: MPIKPLIILPDPILREVSKPVEHVDSTIQKLADDMLETMYDAQGVGLAAIQIGIPLRMLVIDVSRNETQKNPLVIINPEILWLSDERNICKEGCLSIPEYYTEIERPKRLCVRYQDREGKQTEIEADHLLATCLQHEIDHLNGRLFIDHISKIKRDMVIRKFKKRAKEKNAQEAIL
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: HP252_BOVIN
Sequence: MPGRGGQSLSMVCVDVWILALSVLSVMADATSVPVTESCDSQGPPGLPGPPGLPGPPGPPGPPGPPGLRGPTGIPGDIESCLSPPKSAFAVKMNDPLPAPSQPIVFKEALHNDQDHFNLTTGVFTCTIPGVYRFGFDIELFQHAVKLGLMKNDTQILEKESKAKDNYRHLSGNVVLQLTLGDRVWLESKLDTTETEKGPIQSMFFGYLLYGNYPG
What are the official names of this protein?
Protein HP-25 homolog 2.
What are the subcellular locations of this protein?
Secreted.
Protein: VPL9A_POLAB
Sequence: NVCDGDACPDGVCRSGCTCDFNVAQRKDTCFYPQ
What are the official names of this protein?
Turripeptide Pal9a.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUD_CORGL
Sequence: MEKFTTYTGVGVPLQRSNVDTDQIIPAVYLKRVTRTGFEDGLFSNWRQNDPNFVLNTDTYKNGSVLVAGPDFGTGSSREHAVWALMDYGFRAVFSSRFADIFRGNSGKAGMLTGIMEQSDIELLWKLMEQTPGLELTVNLEKQIVTAGDVVISFEVDPYIRWRLMEGLDDAGLTLRKLDEIEDYEAKRPAFKPRTNA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: QUEF_PSYCK
Sequence: MSIHGILGEQTTDYPTEYSPETLYPIARSMGREVIGWQDDKLEVGFDWWQAFELSWLNEQGISQVAIARFGIPASSPFIVESKSLKLYLNSINFTEFGSLETVQTLIAKDLSKCVQAEVNVELFDLEDEHSGLLIAQPDGICIDDALADSTEKVALTLHPDASLLERNTSDAKISEGKTFSFYSNLLRSNCPVTNQPDWGTLAVSITSNKPVNNANMLRYILSFRQHNGFHEQCVEQIFADLSQYYEPSELMVRAWYTRRGGIDINPCRVSDIALLPVPSRLIRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_PONAB
Sequence: MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLRGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLEGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAAEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMVGDFVNMVGKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
What is the function of this protein?
Chaperonin implicated in mitochondrial protein import and macromolecular assembly.  Together with Hsp10, facilitates the correct folding of imported proteins.  May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.  The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring.  In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10.  This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components.  Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
What are the official names of this protein?
60 kDa heat shock protein, mitochondrial, 60 kDa chaperonin, Chaperonin 60, CPN60, Heat shock protein 60, HSP-60, Hsp60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: EUTA_ECOLI
Sequence: MNTRQLLSVGIDIGTTTTQVIFSRLELVNRAAVSQVPRYEFIKREISWQSPVFFTPVDKQGGLKEAELKTLILEQYHAAGIEPESVDSGAIIITGESAKTRNARPAVMALSQSLGDFVVASAGPHLESVIAGHGAGAQTLSEQRLCRVLNIDIGGGTANYALFDAGKISGTACLNVGGRLLETDSHGRVVYAHKPGQMIVDECFGAGTDARSLTGAQLVQVTRRMAELIVEVIDGTLSPLAQALMQTGLLPAGVTPEIITLSGGVGECYRHQPADPFCFADIGPLLATALHDHPRLREMNVQFPAQTVRATVIGAGAHTLSLSGSTIWLEGVQLPLRNLPVAIPIDETDLVGAWQQALIQLDLDPKTDAYVLALPASLPVRYAAVLTVINALVDFVARFPNPHPLLVVAGQDFGKALGMLLRPQLQQLPLAVIDEVIVRAGDYIDIGTPLFGGSVVPVTVKSLAFPS
What is the function of this protein?
Reactivates suicidally inhibited ethanolamine ammonia-lyase (EAL), cyanocobalamin-inactivated EAL and O(2)-inactivated EAL; requires Mg(2+), ATP and adenosylcobalamin.  Reactivation probably occurs by the ATP-dependent exchange of cobalamin.
What are the official names of this protein?
Ethanolamine ammonia-lyase reactivase EutA.
What is the protein family that this protein belongs to?
Belongs to the EutA family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: YGH2_YEAST
Sequence: MGAGIFFSSLCALRDQLREHTILNDYIRYLMTLPCVLFLSSFGQAVIVVLCRVLYFDYSRFRYFLHKSFLSVLGRRVGLGGITVVIKAWQVITHFSVFSGAELYIGGHPCTSLTSVIVV
What are the official names of this protein?
Putative uncharacterized protein YGL072C.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y683_RICTY
Sequence: MIKLKSILNFLYNIANKDGFKGYKECRTSAYKNVFDDSSTKSTSKFHLGISDTKNLLSLQNIIGLILIIFAGVLFYAYILQHEWRYVTLSDAQVKRYRISEKKALSLYQLMKDTHELLTKNNIKYWIESGTLLGAVRHQGIIPFDDDLDIGIMHEDEIHFQQILPQFKQLGYRIKHNKIYVICGERCLDIFIFHKEKDKFVHILYDQYPNDFFYENELYPLKKYKFGNIEVYGPFDPIGNLNRQYPEWDKYAIIYSPHSFHLLFLSNIEKKTKFILTPELLKPAQPFGPLKDKVNIVNSANIYNDMDYH
What are the official names of this protein?
Uncharacterized protein RT0683.
What is the protein family that this protein belongs to?
Belongs to the LicD transferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DCUP_ORITB
Sequence: MSKIIQAFHSSNKNYTPIWFMRQAGRYLPEYQVLKRTTNSFFELCYNPIKAAEATLQPIARFDFDAAIIFSDILVLPDSLGINIRFINNLCPTAEKIPNLLDLQKSKIQNTKISKVYEAIDIVRKKLNKKKSLIGFCGGPWTVLTYILGYNSRNTPKFHEIKSNNKHELIVDSINILTKHTIDHLANQILAGADIVQIFDSWAGILPYQEFSEYVIKPTSNIVKTLKEKFPHIKIIGFPKGAGKLYHKYTKETNVDGISCDYDLQLDEMLKLQKNVLVQGNLNPNTILSKNSKIIEESVIKIMDTLSNNRFIFNLGHGILPETPIKNVELIVKLVKNYHSSE
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_BURMS
Sequence: MSERNAASARTVACLLGPTASGKTAAALALAARRPIEIVSVDSALVYRGMDIGTAKPTRDERAAVPHHLIDIVDPADAYSAAEFRADALRLVAQIAARGRTPLLAGGTMLYYRALTQGLNDLPAADPDVRATLDADAARDGWPALHARLAGIDPATAARLAPNDSQRIQRALEVYLLTGQPMSALLAAPPRDNDAAAGLRFVPVALEPSERAVLHARIAARFDAMLEAGFIDEVERLRRRDDLHLGLPSMRCVGYRQAWEYLDGCTDYRTMRDKGIFATRQLCKRQLTWLRAMPERIVVDCCAPDATVRAVDALERVLDGRAPA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ECPR_ECOSE
Sequence: MTWQSDYSRDYEVKNHMECQNRSDKYIWSPHDAYFYKGLSELIVDIDRLIYLSLEKIRKDFVFINLNTDSLSEFINRDNEWLSAVKGKQVVLIAARKSEALANYWYYNSNIRGVVYAGLSRDIRKELAYVINGRFLRKDIKKDKITDREMEIIRMTAQGMQPKSIARIENCSVKTVYTHRRNAEAKLYSKIYKLVQ
What is the function of this protein?
Part of the ecpRABCDE operon, which encodes the E. coli common pilus (ECP).  ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition.  Positively regulates the expression of the ecp operon (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator EcpR.
What is the protein family that this protein belongs to?
Belongs to the EcpR/MatA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPP_PROM0
Sequence: MLILASASQSRKKLLENCQIEFFQISSDFDETTIQEKNIFNLALELSFQKANSLSENIQNLSLPEELNHGPLEILGCDSIFEFKGEAYGKPSNKEEAFIRWKKMSGEFGFLHTGHTLIIGNFDSTSKIFKITEIIKKTVSSRVYFSNLEDWEIKSYVDTNEPLYCAGGFALEGIGGKYIEKIEGCFSNVMGLSLPWLRKNLYR
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.