Protein: REH2_TRYB2
Sequence: MRAIRLTVACRYLGPFRSVTLSPVVLPVRLFQTQEITPGEVSLVEATDESDRAFGETRKEDFSFDGSSEFPECFKDTKHVDTFSRARVVSFIKRFSQGAVTSSSEVFEGREIVNDNGTPLYHSRVRLPFRSHTGELWAHGVACNSKDAELLAAMHAEHIIDEFGYHIYTLPSMQRKHAEAARKAGRWAPLPDELERTQSPVRVPLPLRRIVDRDETEGGKWLLIDMRPNHYISPSHTLLSPCLFDTTAVHRIKSFLDEHKLSFAQLCTSVEEPGEGGGQSWYVATVSLPPELSTFSEIKAQGKALNREAAVTLACMHAELVLDAHSICLYPSDSTKQKQHALAAWSYGRPAPLPGEDQKNPSHVVCPLPLKQLAVRREDRISCISYEEDIIRRHRALTDQTCEFIETPTLDSSAVEQLKQFLQRENVPRTDPFLVEEVNGYYKATVVLPLPDLYGIRGGVGIAMNATDARVLAAMHAIDVLNILGFHLMDGSTARAEWIAARRARGESVPADTRDPNVLSPSGRRRVATGNSSTQTPSSSTNARSVAAAPDVGTSDPTAPQNTKRRVAKRARVADAQPTEEKDAANSDSDEATSYLKMRETVSKELWNLEPDSPDGYIMVSPTDPETRTQFEQALYSPRQVDLGSKSRIKNYLASVGRRIEEVFFVQRIEAEDNGGQAICRCAVNLPVPRRFGDRIALGEAVDPKDAENLAAMHAELILDTLGIPIYTDSALQRLHVRLCAKCGRNAPVEYSESVAAATASPPPLRREVVGSIHWENKSKRRRAAISVQKGGGPANSQETTSALREDEEPLIAPKERREYTFVPEKDLDLVSRARVHYYLRRNGIAKLEPEYRMELRGLGNVLHIAELTLPLPDVYGKRVAHGSALTKRDAEILCWMHAEQILDAVGLCLFDNLPMLQRRHVECVKRLGRWAPLVSENATKPPHTPTPLPLTLGTTQEKPQYPTPPTNVRQDWEQYAQECQRYIEINVMREHNIFYEMGKTPRTGDETYDAALAEVESMPIDPDAKTVLQRYCNVANVNYPTFWKSRTVGPISCRVCLTTIEVPGHEYLRASGVAWNKEASQRQAAMHALALLRRVEPDFAEFEKQIKAEVVDKVNLVDPAAVLDEEAPVLRRTARVSKKSLGNWDPVSKDFSHEGKVRIIELFTVCFGLQPPLVRHLNRRSGSFVQHFTVVEVTDEDGKTWVGTGRDAGPRFNEPAAFDDLFSKLSRGVQGFQALMDLIRAHPHLDPEHIANVSLTDSQKERILKAVDGLPMVEEEDVAHPEQWADADSDRGIGIMALIAMDASQRAQESQELEAKLQAKLTNEEYQTRYASQRQRLRIYEKRDEILRAISSNQIVIICGTTGCGKTTQVPQYILDDMTEKGMGGDCSIVITQPRRLSAVSIARRVAAERLESIGETCGYSIRLDAKPGRNINFCTSGVLLRLLHSAPLLNGINYLIIDEIHERDINSDFLLILLRQLLHRRKDLHVILMSATLQADQFGKYFGNAPIINVEGYVHAVEEMYLEDLVPIATERNVMTPLLKEAAAALERNGAADGFCPTVVPPTAKYGFLEATADIDYMTIQIAIDHAVRSLDLTDSSILVFLPGWDEINRAKEILERNAKFHIICLHSSVGAEEQMRCFLPAPEGKIKLILSTNIAESGVTIDDVAAVIDVGRGKEKSYVMRKGTTSVGRNEMGSMSQLVTVYASRANCVQRRGRVGRTRPGMCIRLYSKKHFQSLHDFQTPEMLRTHLDSLCLQILALDLGDPADFLQQALEPPSSDHIEAAMKRLHELGATTSTRQLTPLGLRLSRLPVAPKVGKMVIMGAILRCLDSALTIAGVSDTDVFISTREHREAVRLHKEDLSYGTQSDVIASVNAFNFWVTSHYAKTPAEVVYDLQERMLSVPQLLTVSKYKQQFFEIVAGSGFIHMKQNYKDAKNKDRADIFVDQSEYSADSLNVGLVKCVVASGLFPNVVMNRGKRLMRNKLANRLDPSSASVVHRTSQENIGQPYFVYDELVKSSESERLLVRDLTNVSLWTILLMGTSSMPVTYRDDLNLAVVDEWIMFRATFGTLELIRKFKRALNVCLGRKFMNPNDEENNAKLEELRCIIKELVCTPFKPNDLAEKPWEEKGVIIEPCTEPKGGSSEAEKTHVNSSHTPTTSAEAGGDS
What is the function of this protein?
ATP-dependent RNA helicase that unwinds RNA in a 3' to 5' direction and that plays an important role in mitochondrial mRNA editing, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA (PubMed:19850921, PubMed:26769962, PubMed:31034523).  As part of the RET2-containing gRNA-binding (RET2-GRBC) complex, acts as a scaffold for the assembly of mRNA-gRNA hybrids and the recruitment of the RNA editing core (RECC) complex (PubMed:25928631, PubMed:26769962).  Regulates several steps of mRNA editing by the MRBC3010/GRBC6 containing gRNA-binding (MRBC3010-GRBC) complex including loading of unedited mRNA, editing in the first sequence block and subsequent editing progression across multiple sequence blocks (PubMed:25928631).  Also, regulates the RNA substrate content of the MRBC3010-GRBC complex as well as the association of this complex with mitoribosomes (PubMed:25928631).
What are the official names of this protein?
RNA editing associated helicase 2, ATP-dependent RNA helicase REH2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Mitochondrion.