PharMolix/UniProtQA huggingface dataset:
Protein: TKT_DICDI
Sequence: MSNIDFKALERAANETRGLSMDAVAKAASGHLGLPLGSAEIGAALFGNSLIYNPKDTRWLNRDYFVLSAGHGSMFLYSWLHLSGYDVSIEDIKNFRQLNSKTPGHPKFHDTPGVEATTGPLGQGIANAVGIASACKMAAGKFNTEQHQIFNQKVVVLVGDGCLQEGISQEAISFAGHHRLDNLIVFYDSNDVTLDAMAIETQSEDAVKRFESVGFEVQLVLEGNNIGSLINAYQNAKHSKSGKPQIIICKTTIAKGIPEVAGTNKGHGEAGVKFIDSARKNLGLPEEKFFVSGETRQYFEQHEKQLEKLYQEWQATFAEWKSANPKLAQLLESAHEKHEAIDIMKQIPEFPTTPIIATRKAGSDVLQPISQYLPLSVSGSADLHGSTLNYIKEGRDFTPACPTGRNIKFGIREHAMGAMMNGIAYHGLFKVSGATFLVFSDYLRPAIRLAALSHLPVVYIFTHDSVGVGEDGPTHQPVETVSGLRMIPNLDVIRPADPEETAAAFSLAYARADGPTLLSLTRQNLPFLPGTAQKKREGTLRGGYIVVSETAPLRMILIATGSEVQHCVEAAKLLGDDIRVVSMPCTELFDRQSNEYKQSVLPSGCRNRIAMEAGVTSFWYKYVGLDGKVIGIDRFGMSAPGNAVMKQLGMTSENLVNISKQ
What is the function of this protein?
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
What are the official names of this protein?
Transketolase, TK.
What is the protein family that this protein belongs to?
Belongs to the transketolase family.
Protein: ADDB_STRPI
Sequence: MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLEYLSQQASFSITVTRFAQMARYLVLNDLPAKTTLDDIGLGLAFYKCLAELDPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQGSQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLLRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQTEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQTTEEGVQLLIASSENLKKNRYTMLSLVNSARKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDLQGLENPAIPTSPSSKTLTKDTLQALYPAKQEFYLSTSGLTEFYLNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREELNR
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: RL20_KORVE
Sequence: MPRVKRGTKRRAKRKKILERASGYYLTKSKLYRSAKESVERALKFAYTGRKQKKRQYRSIWIVRIGAAAKLNGLSYSRFISGLKKAGVELDRKMLSEIAIHDPQAFAVLAEQAKAAQPAAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PARD_YERPE
Sequence: MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Neutralizes the effect of toxin ParE (By similarity).
What are the official names of this protein?
Antitoxin ParD.
What is the protein family that this protein belongs to?
Belongs to the ParD antitoxin family.
Protein: HLDE_SHEB9
Sequence: MKVSLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVKINQVEDRPGGAANVALNIATLGGQVQLAGLVGQDDTAHALTLGVQTLGVEPQWLTIADKPTITKLRVLSRNQQLIRLDFEEAFDKADSVRLLKQSEALLDSVDVVVLSDYAKGAIDQPRDFIALARAKGVMVLVDPKGSDFGRYQGASLITPNMSEFEAVVGTVTSEADLLEKARGLLKQHHFDAILVTRSEKGMTLVTANAPELHIPTVAREVYDVTGAGDTVISALATSLAAGADLPQACAIANTAAGVVVGKLGTSTVSRIELIEALALHHGESGFGVVSEDQLAYALEQAKLRGERVVMTNGCFDILHAGHVSYLKQAKALGDRLIVAVNDDASVKRLKGDGRPVNQVDRRMAVLAGLASVDWVVPFSEDTPQRIITRLLPNLLVKGGDYKLEDIAGGAEVIAAGGQVQVLGFEDGISTTAIIQNIMANQ
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: CLD12_MOUSE
Sequence: MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTIYTGLWVKCARYDGSSDCLMYDRTWYLSVDQLDLRVLQFALPLSIVIAMGALLLCLIGMCNTAFNSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWAIFYNSHLNRKFEPVFTFDYAVFVTIASSGGLFMTALLLFVWYCACKSLSSPFWQPLYSHAPGMHTYSQPYSSRSRLSAIEIDIPVVSHST
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
What are the official names of this protein?
Claudin-12.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: ASTD_PSEPF
Sequence: MNSLYIAGEWLAGQGEAFQSLNPVTQQVLWSGEGATAAQVESAVQAARQAFPGWARRTLEDRISVLEAFAAALKNHADELARTIGEETGKPLWEAATEVTSMVNKIAISVQSYRERTGEKSGPLGDATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNSVLFKPSELTPKVAELTVKCWIEAGLPAGVLNLLQGARETGIALAANPGIDGLFFTGSSRTGNHLHQQFAGRPDKILALEMGGNNPLVVDQVADIDAAVYTIIQSAFISAGQRCTCARRLLVPEGAWGDSLLKRLVEVSSTIEVGAFDQQPAPFMGSVVSLGAAKALMDAQAHLLANGAVSLLAMTQPQAQSALLTPGIVDVTAVADRSDEELFGPLLQVIRYADFAAAIAEANDTAFGLAAGLLSDSEERYQQFWLESRAGIVNWNKQLTGAASSAPFGGVGASGNHRASAYYAADYCAYPVASLETPSLVLPAALTPGVKMA
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: QUEC_SALPC
Sequence: MKRAVVVFSGGQDSTTCLAQARHQYDEVHCVTFDYGQRHRAEIDVARELALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPNADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVNLGMAKDIRFETPLMWIDKAETWALADYWGQLDLVREETLTCYNGIKGDGCGHCAACNLRANGLNHYLSNKAAVMAAMKQKTGLR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: NDPA_PROMH
Sequence: MSLDINQLVLHQLIKRDEQTLEVVLRDSLLDIEPVVQEMVEELHRVYSAKSKAYGLFNEESELAQALRLQRQGEEEFLGFSRAATVRLKDELAKYPFAEGGTVLFCHYRYLAVEYLLIAVLNSCNSMWVNDSLDVSSTRYLDIPHADIIARIDLTEWETSPDSLRYLTFLKGRVGRKVSDFFMDFLGAQEGLNTKVQNKGLLQAVDDFCEASDMNKQERQTCREQVYSYCNEQLQSGEEIALTELAQELPPLGDQNFAQFTEEKGYELAETFPADRSTLRQLMKYSGSGGGLTVNFDAKLLGERIFWDPATDTLTIKGTPPNLRDQLQRRVSEK
What are the official names of this protein?
Nucleoid-associated protein PMI0825.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: KHSE_CUPNH
Sequence: MAVFTTVSQDEIARWLLDFNLGEVRELRGIASGIENSNFFLTTEHDGQTRQYVLTIFERLTFAQLPYYLHLMAHLAERGIRVPAPIPARDGEILRPLKGKPATIVTRLPGASQLAPDAQHCAEVGDMLARMHLAGQDYPRQQPNLRSLPWWRQTEPEILPFLDAGQRALLQQEIAHQAAFFASTDYAGLGSGPCHCDLFRDNALFEEDGSGRHRLGGFFDFYFAGNDKWLFDVAVTVNDWCIDLASGELDPARTQALLRAYHAVRPLTATEAAHWQDMLRAGALRFWVSRLWDFYLPREADMLQPHDPTHFERILRRRIGADPASAPLPWI
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: CLMP_XENTR
Sequence: MHTLIRSFLGLWYVLGALAQTEIKLVADENVTLPCRHSLGHLGIQSLDIEWLSNISDHGKQVLLSYSGGQVYNAENHKGRYSFVSKYLEGDASLFIRSLQPSDAGQYICKVKNAGQYQWSFITVIVLVKPSELACSSEGAQLEGKNVTLNCKSTAGTKPLNYRWVRVNLKDNVERPVQSTARIGPENQLLLHNLSKTDNGSYRCEVSNEVGKRTCDVDVTVQSVSNTGILAGVACGVVVGVFLIFFTVWLLFHKKEFKKREEEEFFNEIREDAEAPKARLVKPGSSSSDSRSSQSGSSSTRSTTNSASRSQRTHSTQETPHGEQRHHCLEKI
What are the official names of this protein?
CXADR-like membrane protein, Adipocyte adhesion molecule, Coxsackie- and adenovirus receptor-like membrane protein, CAR-like membrane protein.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
Protein: GLMM_NEIMA
Sequence: MAKKYFGTDGVRGEVGQFPITPDFVLKLGYAAGQVLVQHDTDQKPTVLIGKDTRISGYMLEAALVAGFTAAGVNVVQTGPLPTPGVAYLTRALRLSAGVMISASHNAYSDNGIKFFAEGGVKLSDEIELEIEAKIDEEMKTQPSARLGRARRISGADDRYIEFCKSTFPSHSDLRGLKLVIDTANGAGYGVAPKVFHELGAQVVSIGDEPNGYNINEKCGATYTKTLQAAVLQHEADYGIALDGDGDRLMMVDKNGKVYDGDSLIYVIAKARAREGINIGGVVGTVMTNMAMEIALKEQGVDFCRAKVGDRYVLEQLNQRSWLIGGEASGHILCMDKHNTGDGIISALQVLAALQTLNQDLATVCADWQPYPQTMINVRIQKGQKWQEASKDVLAEVEKELEGKGRVVLRASGTEPVVRVMVEARQADWARDGAERIASAIGSL
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: CR11_RANCA
Sequence: MASLKKSLFLVLLLGFVSVSICEEEKRQEDEDEHEEEGESQEEGSEEKRGLLSVLGSVAKHVLPHVVPVIAEHLG
What is the function of this protein?
Is inactive.
What are the official names of this protein?
Caerin-1.1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Caerin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RR16_THAPS
Sequence: MLKLRLKRNGRKRQPAYRLVIMESTTRRNGRPVDEVGYYNPITKESYFNKEKIVKWLSYGVQPTETVFQLLKKSNLIEI
What are the official names of this protein?
30S ribosomal protein S16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TIMP1_PONAB
Sequence: MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA
What is the function of this protein?
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor.  Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16.  Does not act on MMP14.  Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1.  Plays a role in integrin signaling (By similarity).
What are the official names of this protein?
Metalloproteinase inhibitor 1, Tissue inhibitor of metalloproteinases 1, TIMP-1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I35 (TIMP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: UP1_HALAI
Sequence: MVLHVITALLSIGLCYGMPPSGTTAAPTAYNGAAAQESLIPQQAHHARASLFPQQQRNPSYQTMGSYGSSLFDPSVFPVAHAPASQAGGLLGRAVARTSGGQANAGASSQNLMRSIMQNTMTGRLMGLDNQEIAHLNSVRTLGVGHATIHRLMKIDQIPSYNYYLALKNKPAQFSKAQNYLMTLNRMENHATDSQLEAMGARMLMQRNMDPDLARMVQLDAARGVYGDRLQRVLLGGSQMSLLG
What are the official names of this protein?
Uncharacterized protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: PCP_STRCO
Sequence: MTRVLITGFAPFGGERVNPSWQAASLVAAEPPAGLAVTAAELPCVFGESLDALRDAIRADNPDLVLCLGQAGGRPGVTVERVGINVDDARIPDNAGGQPIDEPVVPDGPAAYFSTLPVKACVAAMREAGVPAAVSNTAGTFVCNHVAYGLGHLIATEFPHLRGGFAHVPWAPEQVPDGTAPALPPATVAHGLRALLAAAARTPAEQDLKVTEGATH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_THEAC
Sequence: MAKDYYKILGVDRNATDEEIKKAFRELAKKWHPDLHPENKQEAEEKFKEISEAYEVLSDPQKRRMYDQTGTVDFGAGGQNFNWDNFTHYSDLNDIFNDIFGGNFASDFFSGFGRGQREEQYDLDLYTNLDITLEDAYYGTEKRIKYRRNAMCPDCNGTGAKNGKLITCPTCNGTGQQRIVRGQGFFRMVTVTTCQTCGGRGRIPEEKCPRCNGTGTVVVNEDISVKIPKGATDNLRLRVQGKGQSYNGRTGDLYVVLRVRNDRNVQRINDDLMIDQKINFAQAALGDTIEVNLFREKYSLKIPEGTQPGEVLRIKGAGMPHLNGHGSGDLLVRVNVEVPKRLTQKQKDLIREIFDIKENHRSWFH
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_BACC7
Sequence: MPKPVIAIVGRPNVGKSTIFNRIVGERVSIVEDIPGVTRDRIYSAGEWLNHEFNIIDTGGIDIGDEPFLTQIRQQAEVAIDEADVIIFMTNGRDGVTAADEEVAKILYRSNKPVVLAVNKVDNPEMRSDIYDFYALGFGEPFPISGTHGLGLGDLLDEAAQHFPKIEEDGYDEDTIRFSLIGRPNVGKSSLVNALLGQERVIVSNVAGTTRDAVDTPYSKDGKDYVIIDTAGMRKKGKVYESTEKYSVLRALRAIERSDVVLVVLDGEEGIIEQDKKIAGYAHDSGRAVVIVVNKWDAVKKDEKTMKAFEENIRAHFQFLEYAPIVFLSAKTRKRTQTLIPVIDEVNESHSIRIQTNVLNDVIMDAVAMNPTPTHNGSRLKIFYATQVAVKPPTFVVFVNDPELLHFSYERFLKNRLRESFGFVGTPIHIIARARD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: URE1_SHEHH
Sequence: MAKISRQAYADMFGPTVGDRVRLADTALMLEVEQDLTTYGEEVKFGGGKVIRDGMGQSQALSKDCVDAVITNALILDHWGIVKADIGIKHGRIVGIGKAGNPDVQPNVDIVIGAGTEAIAGEGKIITAGAIDTHVHFICPQQVEEALCAGTTTFIGGGTGPVAGSTATTVTPGIWNMHRMLEAADELPINVGLFGKGTVSNPDAIREQIANGAMGLKIHEDWGATPAAIDTCMTVADEMDVQVAIHSDTLNEGGFYEATTKAIGDRVIHVFHTEGAGGGHAPDVIKSVGEPNIIPASTNPTMPYTINTVDEHLDMLMVCHHLDPAIAEDVAFAESRIRRETIAAEDILHDLGAISVMSSDSQAMGRVAEVAMRTWQCAHKMKLQRGPLEGDSELSDNTRLKRYVAKYTINPAITHGISHEVGSIEKGKLADIVLWDPAFFGVKPALVLKGGLAVYAPMGDINGAIPTPQPVHYRPMYAATGKARAATSMTFLPKAAIEAGITEKLKLTHLIGEVKGCRNIRKKDMIHNSYTPVIELDSQTYVVKADGMALVCEPLAELPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_BACC2
Sequence: MTSIAISSGSFDPITLGHLDIIKRGAKVFDEVYVVVLNNSSKKPFFSVEERLELIREATKDIPNVKVDSHSGLLVEYAKMRNANAILRGLRAVSDFEYEMQITSMNRKLDENIETFFIMTNNQYSFLSSSIVKEVARYGGSVVDLVPPIVERALKEKFQTPLK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORF3_HEVCH
Sequence: MGSRPCALGLFCCCSSCFCLCCPRHRPVSRLAAAVGGAAAVPAVVSGVTGLILSPSQSPIFIQPTPSPPMSPLRPGLDLVFANPPDHSAPLGVTRPSAPPLPHVVDLPQLGPRR
What is the function of this protein?
Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity (PubMed:19339479, PubMed:21068219, PubMed:28096411, PubMed:30532200).  Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway (PubMed:19339479, PubMed:21068219).  Acts also as a viroporin and forms ion conductive pores allowing viral particle release (PubMed:28096411).  Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways (PubMed:27270888, PubMed:29872132).  Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression (PubMed:26492885).  Interacts with host microtubules (PubMed:19369329).
What are the official names of this protein?
Protein ORF3, pORF3, Vp13.
What is the protein family that this protein belongs to?
Belongs to the hepevirus ORF3 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane. Host cytoplasm. Note=The N-terminal region seems to associate with the cytoskeleton probably via one of its hydrophobic regions.
Protein: HSSR_STAAE
Sequence: MVQCLVVDDDPRILNYIASHLQIEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDGFQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYNINSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWGYDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
What is the function of this protein?
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence.  Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood.
What are the official names of this protein?
Heme response regulator HssR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTU1_DROME
Sequence: MHIICKSQCGNRAALKRPKTGDALCKECFFAAFEAEIHHTISSSNLFRRGEKVAVAASGGKDSTVLAHVLKLLNERHNYGLELVLLSIDEGITGYRDDSLETVKQNRDDYQMPLKILSYEELYGWTMDRIVAQIGRSNNCTFCGVFRRQALDRGAKLLGVDSIATGHNADDIAETVLMNVLRGDTARLRRCTSIRTGGGEDTIPRVKPLKYSYEKEIVMYAHYKKLVYFSTECVFAPNAYRGHARAFLKDLEKVRPSVIMDIIYSGEQLRFKDTVKKPERGTCTRCGFVSSQQPCKACVLLEGLNRGLPKLGIGKKSKGERMIAKQNQELALRERANLVKNDF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATRIP_DROME
Sequence: MAKRFSAMKDFARCKKPRLDVSVTRGSARPSPPRNNFDGILWDDDDDVILMATQLAEAEIEAEERKKKGGTEVDIGNSEVTFSEFAPTFQGSTSTQQMFPPPPPPQKKPTSLDMDAIFADDDDFDFLAVTLMDSEPQKMPEPKTSTSRITTSSISVQQKTTTTTTINATQSRQQEHQLKFLMDRIEALKRENAQLEKNLGDSKERNEIKSGEVSLLRDELKHLRQQLQASKMEKLALADETNRDCNKKVAEAAKQIAAKDIELKIKNAEFSKLKTQQKAHERSMNSSMSILQAAPDPLEKRLSLRLNRLNIHRSVPGLKTDNGSVFEYSENEDQTKKRRNHFELELKQLLLHYARLQAKPESVDNLLPRILSSVGKVFTEFASYAQSLDFPHNCMLYPYNPHNLEEEVHRISLTHQSCLYDNEKAVPLRRFIATLALICRREERISRGLTEWKENDLGLLDMAIEAITKLGFSYEVGQHFGLLEALTSLLNSLLQENALLQHNEELLFDLLKQLVFTRPSPWVFAELSSCFLSCLRHPQLMDKMCVNSPKDCFVSDRVRSVYRFGPDSCLLQVYAGLLELCFFSETPLRQDYFQLLLKIGGNHVRFAFECFKNPPDFILEMLPYFADDGDEDSSDGTLMKTGTSLSFNSTGAVQGSVSNGSTSASVSNPNQNSNSSTTQRGKGCECYVKLCLSAVTIVFQVMHQWMLHSRKAGTEEVGEISRIAVHLLSLVFHEYYLTCLFRDSEETTKHYLSLICNWWSEHANLLGFQSIHLRLLNQLVKAHFMLKPLHLEAKPNNPVNDLSEWKRIVKNADDQRAVKSAVTVDPSKLLNTDFFSALKREENTFE
What is the function of this protein?
DNA damage checkpoint protein required for chromosome break repair and for genomic stability during development.
What are the official names of this protein?
ATR-interacting protein mus304, Mutagen-sensitive protein 304.
What is the protein family that this protein belongs to?
Belongs to the ATRIP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTRC_NEOYE
Sequence: MKKQNLVSFPENLEAMRKFSETYAKRTGTFFCIDSSVTAVVIEGLARHKDQYGAPLCPCRHYEDKKAEISATYWNCPCVPMRERRECHCMLFLTPDNEFASDLQEIDKTTLTEQIS
What is the function of this protein?
Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
What are the official names of this protein?
Ferredoxin-thioredoxin reductase, catalytic chain, FTR-C, Ferredoxin-thioredoxin reductase subunit B, FTR-B.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin thioredoxin reductase beta subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DTD_HALHL
Sequence: MITVIQRTGSARVRVGGEVVGEIERGLVALVCAVHGDGSAQAQRLAERVLGYRVFPDAEGRMNGSALDLGCGVLAVPQFTLAADTRKGMRPSFGPAADPQTGQALFETFLEALRERATGPVASGVFGADMQVELVNDGPVTFWLEAPPRPAGPV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSG_BORA1
Sequence: MKLFPIFSDIKGRCVLVVGGGAVATRKAQALLEAGAAVSVGAPTLTPELARLAQGQTITHLQGEFDADWLKDAWLIIAATDDRTVNTRVYEAACARRQFCNVVDDPALSSFQVPSIVDRSPLIVAISSSGLAPVLARRLRERLESLFDHSLGALAELAARYRPAIRAARADLKERRRFYDWLLDGPVAAALRRAQPQQAQEALDEALARPALSQDGRVVLVGAGPGDPGLLTLKGLRALNEADVILHDRLVSAEVLALARRDAERITVGKRLGENHNATQARIHELMVEHARAGRRVVRLKGGDAFIFGRGGEELEHLRAHGVDYEVVPGITAALACAAYAGIPLTHRDYAQSVHLVTAHCRADEEALDWDGLARGQQTLAFYMGVGQLDILSARLVAHGRPGSTPFALIENGSRPSQRVVMGRLSQLAERAREQAVASPALLIVGEVAALADRLAWFGKP
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.