PharMolix/UniProtQA huggingface dataset:
Protein: ZAPD_ECO5E
Sequence: MQTQVLFEHPLNEKMRTWLRIEFLIQQLTVNLPIVDHAGALHFFRNVSELLDVFERGEVRTELLKELDRQQRKLQTWIGVPGVDQSRIEALIQQLKAAGSVLISAPRIGQFLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLPQAQRDCQVETWIASLNPLTQALTMVLDLIRQSAPFRKQTSLNGFYQDNGGDADLLRLNLSLDSQLYPQISGHKSRFAIRFMPLDTENGQVPERLDFELACC
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: IDI2_SULIL
Sequence: MPDIVNRKVEHVEIAAFENVDGLSSSTFLNDVILVHQGFPGISFSEINTKTKFFRKEISVPIMVTGMTGGRNELGRINKIIAEVTEKFGIPMGVGSQRVAIEKAEARESFAIVRKVAPTIPIIANLGMPQLVKGYGLKEFQDAIQMIEADAIAVHLNPAQEVFQPEGEPEYQIYALEKLRDISKELSVPIIVKESGNGISMETAKLLYSYGIKNFDTSGQGGTNWIAIEMIRDIRRGNWKAESAKNFLDWGVPTAASIMEVRYSVPDSFLVGSGGIRSGLDAAKAIALGADIAGMALPVLKSAIEGKESLEQFFRKIIFELKAAMMLTGSKDVNALKKTSIVILGKLKEWAEYRGINLSTYDKVRKRE
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_LACLS
Sequence: MNIKEGKFLETILAEKKQEIAQMPDENSKPIRQTYRLYDYLKKHSDQLQVIAEVKKASPSLGDINLEVDIIAQAKNYEQAGAAMISVLTDPVFFKGNIEYLREISKNVQIPTLNKDFIIDKKQINRALNAGATVILLIVACFENDFEKLEELYNYAISLGLEVLVETHNKAELDRAHQLAAKIIGVNNRNLKTFEVSLQNSTDLVPYFKEENVYISESGIFGKKEAQKVAENFNGILVGTALMQANNLTKSLTDLKIKRKNDEH
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: RND3_HUMAN
Sequence: MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKSCTVM
What is the function of this protein?
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
What are the official names of this protein?
Rho-related GTP-binding protein RhoE, Protein MemB, Rho family GTPase 3, Rho-related GTP-binding protein Rho8, Rnd3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
Protein: RUVB_STRP8
Sequence: MARILDNNVMGNEEFSDRTLRPQYLHEYIGQDKVKEQFAIFIEAAKRRDESLDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAVEKAGDLVAILNELEPGDILFIDEIHRMPMSVEEVLYSAMEDFYIDIMIGAGDTSRSIHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYQEKDLTEIVERTATIFEIKIDHEAARKLACRSRGTPRIANRLLKRVRDYAQIIGDGIITAQITDRALTMLDVDREGLNYIDQKILRTMIEMYQGGPVGLGTLSVNIAEERNTVEEMYEPYLIQKGFLMRTRTGRVATQKAYRHLGYPYQNT
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RS13_LIMRJ
Sequence: MARIAGVDLPRDKRIVIGLTYIFGIGDSTAKKILENAGVSEDIRVRDLTPDQEEKIRAQVDQIQVEGDLRREVSMNIKRLQEIGSYRGMRHRRGLPVRGQHTKNNARTRKGKAVAIANKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: KAB17_OLDAF
Sequence: GIPCAESCVYIPCTITALLGCKCKDQVCYN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Kalata-B17.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: NQOR_ECOL5
Sequence: MAKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPVATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQEQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELSIARYQGEYVAGLAVKLNG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: ERPA_SALDC
Sequence: MSDDVALPLQFTDAAANKVKSLIADEDNPNLKLRVYITGGGCSGFQYGFTFDDQVNEGDMTIEKQGVGLVVDPMSLQYLVGGSVDYTEGLEGSRFIVTNPNAKSTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: MTNA_YEAST
Sequence: MSLEAIVFDRSEPENVSVKVLDQLLLPYTTKYVPIHTIDDGYSVIKSMQVRGAPAIAIVGSLSVLTEVQLIKHNPTSDVATLYSLVNWESTKTVLNKRLDFLLSSRPTAVNLSNSLVEIKNILKSSSDLKAFDGSLYNYVCELIDEDLANNMKMGDNGAKYLIDVLQKDGFKDEFAVLTICNTGSLATSGYGTALGVIRSLWKDSLAKTDKADSGLDNEKCPRMGHVFPLETRPYNQGSRLTAYELVYDKIPSTLITDSSIAYRIRTSPIPIKAAFVGADRIVRNGDTANKIGTLQLAVICKQFGIKFFVVAPKTTIDNVTETGDDIIVEERNPEEFKVVTGTVINPENGSLILNESGEPITGKVGIAPLEINVWNPAFDITPHELIDGIITEEGVFTKNSSGEFQLESLF
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MCRG_METFE
Sequence: MAQFYPGSTKIAENRRKFMNPDAELEKLREISDEDVVRILGHRAPGEEYPSVHPPLEELDEPEDPIKDIVEPTEGAKAGDRVRYVQFTDSVYFAPAQPYIRSRAYLWRYRGADAGTLSGRQIIEARERDVEKIAKELIETEFFDPARTGIRGKSVHGHSLRLDENGMMFDMLRRQVYDEETGRVKMVKNQIGDEFDEPIDLGEPLDEETLKEKTTIYRIDNIPYREDKDLLEIVQRIHQLRSEAGFSPE
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis.
What are the official names of this protein?
Methyl-coenzyme M reductase subunit gamma, Coenzyme-B sulfoethylthiotransferase gamma.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCEE_BOVIN
Sequence: MARVLKVAAASAAGLFPRLRTPVSTVRTSASLSSHPGAGPVWNLGRLNHVAVAVPDLEKARAFYKNVLGAEVGEPVPLPEHGVSVVFVNLGNTKMELLHPLGSDSPIAGFLKKNKAGGMHHVCIEVDNINVAVMDLKEKKIRILSEEAKIGAHGKPVIFLHPSDCGGVLVELEQA
What is the function of this protein?
Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism.
What are the official names of this protein?
Methylmalonyl-CoA epimerase, mitochondrial, DL-methylmalonyl-CoA racemase.
What is the protein family that this protein belongs to?
Belongs to the methylmalonyl-CoA epimerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RR19_GUITH
Sequence: MSRSLSKGPYIAAHLLKKLNNVDIQKPDVVIKTWSRSSTILPNMVGATIAVYNGKQHVPVYISDQMVGHKLGEFSPTRTFRSHIKSDKKAKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PKN1_CHLMU
Sequence: MEEQSTVEYWGDYKVIAELEQGLWSRDVLTEHRFIKKRYVLKILPSELSLSEDFMKVFQKVIVQLATIRHPSLVAIENVSQEKDRYFIVTEENSGTISLAKYLSGRKLSEEEIVYLIQQLCEVLELVHEIGLAHGQINLHSVHVSFINGVANIYLPEVGFASLLRERMFSSIMQKASMQESVECIRDLLVFEAPEEKSTNHRATDAYSVGVLAYYLLVGAFPWGAFPKPSSCIPDSIYDWDSFILSCLQQQQQARPKRLRDALKKKTLGEQLQSTIDHCRESLRAMEVQEEVSEPIAPTSLIREGEKLFEGKEEQQAFVLVEAKSIDEAMVTTVDSEEVSESGEGYVNPLQSLLAREPVVSRYVEIEREEVKPQPLSTEMVFIEGGDFSRGSRDGQRDELPVHNITLPGFLLDIHPVTNEHFVRFLEFIGGEQDEHYNELIRLKDSRIQRRSGRLIIEPGYAKHPVVGVTWYGASSYASWIGKRLPSEAEWEVAAAGGKLGMRYPTGEDVDKSKANFFSSDTTPVMSYPANILGLYDMAGNIYEWCQDWYSYDFYENSALEPDSPQGPPQGVYRVLRGGCWKSLKEDLRCAHRHRNNPGAINSTYGFRCAKDVK
What is the function of this protein?
Together with the serine/threonine kinase PknD, may play a role in the specific interactions with host proteins during intracellular growth.
What are the official names of this protein?
Serine/threonine-protein kinase pkn1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: FCN2_BOVIN
Sequence: MELGGAAGALGPSGPLLVCLCFGTLAAQAADTCPEVKLVGLEGSDKLSILRGCPGLPGAPGLKGETGAAGLKGERGLPGVPGKAGPAGPKGSTGAQGEKGARGEKGESGQLHSCATGPRTCTELLTRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRKDGSVDFFRTWTAYKQGFGSQLGEFWLGNDNIHALTAQGTSELRVDLMDFEGNHRFAKYQSFRMADEAEKYKLVLGAFVEGNAGDSLTDHGNHFFSTKDRDNDESPSNCAAQFQGAWWYHSCHSSNLNGRYLRGPHTSYANGINWKSWGRYNYSYKVSEMKLRLT
What is the function of this protein?
May function in innate immunity through activation of the lectin complement pathway.  Calcium-dependent and GlcNAc-binding lectin (By similarity).
What are the official names of this protein?
Ficolin-2, Collagen/fibrinogen domain-containing protein 2, Ficolin-B, Ficolin-beta, L-ficolin.
What is the protein family that this protein belongs to?
Belongs to the ficolin lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYSD_RHIE6
Sequence: MPDSRPDTELSNPQSAKAPLDPHLKALENESIHIFREVAAEFERPVMLYSIGKDSSVLLHLARKAFYPGRVPFPLLHVNTGWKFREMIAFRDETAKKYDLDLIEHINPRGAAENITPFTHGSAAFTDIMKTESLRQALDAGQFDAAFGGARRDEEASRAKERIYSFRTPDHRWDPRNQRPELWNVYNGMIRKGESVRAFPLSNWTEVDIWRYIQAEDIPLVPLYYAKMRKFVERDGMMILAEDPRLELLPGEVRQEGMIRFRTLGDFPLTGAIRSQATTLQEVIAELEIATVSERQGRAIDRDQSGSMEKKKREGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: RFX2_MACFA
Sequence: MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSAPKGAQMQPVSLPRVQQVPQQVQPAQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSAASYFEAPGGAQVTVAASSPPAVPSHSMVGITMDVGGSPIVSSTGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSSLHSTPEQTMAAQSQHHQQYIDVSHVFPEFPAPDLGSVLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDERRGSEAGPDAHSLGEPLVKRERSDPNHSLQGI
What is the function of this protein?
Transcription factor that acts as a key regulator of spermatogenesis.  Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function.  Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters.  Probably activates transcription of the testis-specific histone gene H1-6.
What are the official names of this protein?
DNA-binding protein RFX2, Regulatory factor X 2.
What is the protein family that this protein belongs to?
Belongs to the RFX family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly expressed in the nucleus and at lower level in cytoplasm.
Protein: RS8_MYCS2
Sequence: MTMTDPIADFLTRLRNANSAYHDEVTLPHSKLKANIAEILKREGYISDYRTEDARVGKSLVVQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: THII_BACC0
Sequence: MMTYEYILVRYGEMTTKGKNRSKFVSTLKDNVKFKLKKFPNIKIDATHDRMYIQLNGEDHEAVSERLKDVFGIHKFNLAMKVPSELEDIKKGALAAFLQVKGDVKTFKITVHRSYKHFPMRTMELLPEIGGHILENTEDITVDVHNPDVNVRVEIRSGYSYIMCDERMGAGGLPVGVGGKVMVLLSGGIDSPVAAYLTMKRGVSVEAVHFHSPPFTSERAKQKVIDLAQELTKYCKRVTLHLVPFTEVQKTINKEIPSSYSMTVMRRMMMRITERIAEERNALAITTGESLGQVASQTLDSMHTINEVTNYPVIRPLITMDKLEIIKIAEEIGTYDISIRPYEDCCTVFTPASPATKPKREKANRFEAKYDFTPLIDEAVANKETMVLQTVEVVAEEEKFEELF
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_CITBB
Sequence: MSRMYETIYIVQPDLGDEEIKALSTKVQDVIASMNGDFKRVEDWGTRKLAYPINKNPRGRYFYLRFDGDSGLIAELERRLRLDDKVIRYQSVKLETEVVAPAAAPVKSAEEGTEEVAAEAATEAPAETTTTVEG
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: IPYR_CHLTA
Sequence: MSKTPLSIAHPWHGPVLTRDDYESLCCYIEITPADSVKFELDKETGILKVDRPQKFSNFCPCLYGLLPKTYCGDLSGEYSGQQSNRENIKGDGDPLDICVLTEKNITQGNILLQARPIGGIRILDSEEADDKIIAVLEDDLVYGNIEDISECPGTVLDMIQHYFLTYKATPESLIQAKPAKIEIVGLYGKKEAQKVIRLAHEDYCNLFM
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_RHOCS
Sequence: MANVAVVGSQWGDEGKGKIVDWLSSRADVVVRFQGGHNAGHTLVIGDVEYKLSLLPSGVVRPGKLSVIGNGVVVDPWALLREIDTIRAKGVTVTPETLLVAENCALILPLHGAVDRAREEARGASKIGTTGRGIGPAYEDKVARRAIRLCDLADDRVLEDKVDHLLFHHNALLRGLGAAEIDKAELMAQIAEVAPRILPYAAVVWQRLDEAKRARKRILFEGAQGAMLDVDHGTYPFVTSSNTVAGNAAAGSGMGPGVVGYVLGITKAYTTRVGSGPFPTELTDATGEQLGLRGREFGTVTGRKRRCGWFDAVMVRQAIKTGGITGIALTKLDVLDGFSELKVCTGYRYQGEIIHHLPAGQTAQAAVEPVYETFQGWSESTRGARSWADLPATAVKYVRRIEELVEAPVTLLSTSPERDDTILMRDPFED
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_BART1
Sequence: MTQQENDTQKRFFNDNLQIVDDAIFNAMRGEFERQQHEIELIASENIVSRAVLEAQGSVLTNKYAEGYPRKRYYGGCQFVDLVEDLAIERAKQLFGAAFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNAGGHLTHGSSVNMSGKWFDVVSYGVRQEDQIIDMDEVERLAKERKPKLIIAGGSSYPRFWDWERFREIADEIGAHLLVDMSHIAGLVAGGVHPSPVPHAHIVTTTTHKSLRGPRGGLILTNDEALSKKINSAIFPGLQGGPLMHVIAAKAVAFGEALHPSFKSYSVNVVANAKTLAKTLQSNGFNIVSGGTDNHLLLVDLRSKNLTGKRAELALGRAHITCNKNGIPFDPETPSITSGIRLGSPAATTRGFLEKEFVQVAHLIAEVLDGLRNAKSDEDNHAVEMAVKKKVEDITNQFPLYSYLSTR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU6C_NEPOL
Sequence: MEIVQNFSSAALTTGILLGCLGVIFLPSIVYAAFLLGAVFFCLAGIYVLLHADFVAAAQVLVYVGAINVLILFAIMLVNPQDAPPRALDSPPLIPGIACIGLLGVLVQMISTTSWLTPPWTPEPNSLPVLGGHLFSDCLLAFEVMSLVLLVALVGAIVLARREPVERSS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: WDR12_DROER
Sequence: MDVENGEGQVQVHLKTKQEHYAVPDVPYAIDGTVTTVELNTFVNALLRQKDGSSDTDFDFLVFDEYLRGRLCDHLREKAISFEDAIEIEYVERFPAPEPQDCLLHDDWVSAVKASGKWILSGCYDNTLNLWTNKGKHILTISGHTAPIKAVDWISLDEETGRFVSTSQDQTAMLWQWNVGSNSVECVSVCKGHERGVDSVSVSPDGLRFATGSWDTMLKVWSAEQEDAAEGSSKRMKESGVRTPKITLQGHRESVSAVQWMDASTLLTGSWDHTLKVWDLSLEGIKTEISTNKSIFDASYSKLNRLILTASADKNLRLYDPRTNQGSVVRNTYLGHNAWVQTVMWSTTEEFLFVSGAYDNQNKLWDCRSPKAPLYDLLGHGEKVLDIDWSNPKYIVSGGVDNTVRVFKSRKALAEDTEAK
What is the function of this protein?
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein WDR12 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: YCLD_BACSU
Sequence: MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMISAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKDAEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR
What are the official names of this protein?
Uncharacterized protein YclD.
Protein: RUVA_BACFN
Sequence: MIEYIKGEIAELSPATAVIDCNGLGYAVNISLNTYSAIQGKSSCKLYIYEAIREDAYVLYGFADKQERELFLLLISVSGIGGNTARMILSALSPAELVNVISTENANMLKTVKGIGLKTAQRVIVDLKDKIKTGAMAATAVGGAAGALLPAMNAEVQEEAIAALTMLGFAAAPSQKAVLAILKEEPDAPVEKVIKLALKRL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: DIH45_AGRIP
Sequence: LYAMSPMAARYSAGAPWLYLLADMPRDSQRLVDPADLHEGRARPKRKMPSLSINNPMEVLRQRLILEVARKQMREANQRQAVANRLFLQNVGKRGFWANSAPTRYDN
What is the function of this protein?
Regulation of fluid secretion.
What are the official names of this protein?
Diuretic hormone 45.
What are the subcellular locations of this protein?
Secreted.
Protein: MCE1_NEUCR
Sequence: MEQPGPITDIAKPGIKAPRDLAISLREEVARILGRSSIGFPGAQPVSFARKHLEELRREDYYVCEKSDGIRYLLYLTVDEEGQEVQYLIDRKNDYWFLPRNSMHFPMPNDIQAFHRGTIIDGELVMDTVPGTNGRKEPRFLVFDLLALDDKAELLNKPLDKRLGYFSAYIYEPYKKLLQQFPQEIPFMAFKVEMKRMELSYGIETMFREVIPALKHDSDGLIFTCRTTPYHFGTDPHILKWKAPHENTLDFRMRLNFPLVQATEAELDEGFPEQFTDYDSVPQAELYVFCGNDGPGGSKYELFPDPLYIAEDEWETLKALGDPLQDRVVECCLDAENRWRLFRFRDDKNEANHTSTVSSVMASIRDGVSDQELLSAATAIKESWKIRAQKRKEQQQQQQPKH
What is the function of this protein?
Second step of mRNA capping.  Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.
What are the official names of this protein?
mRNA-capping enzyme subunit alpha, GTP--RNA guanylyltransferase, GTase, mRNA guanylyltransferase, mRNA processing protein 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic GTase family.
What are the subcellular locations of this protein?
Nucleus.