PharMolix/UniProtQA huggingface dataset:
Protein: SPAT2_HUMAN
Sequence: MGKPSSMDTKFKDDLFRKYVQFHESKVDTTTSRQRPGSDECLRVAASTLLSLHKVDPFYRFRLIQFYEVVESSLRSLSSSSLRALHGAFSMLETVGINLFLYPWKKEFRSIKTYTGPFVYYVKSTLLEEDIRAILSCMGYTPELGTAYKLRELVETLQVKMVSFELFLAKVECEQMLEIHSQVKDKGYSELDIVSERKSSAEDVRGCSDALRRRAEGREHLTASMSRVALQKSASERAAKDYYKPRVTKPSRSVDAYDSYWESRKPPLKASLSLRKEPVATDVGDDLKDEIIRPSPSLLTMASSPHGSPDVLPPASPSNGPALLRGTYFSTQDDVDLYTDSEPRATYRRQDALRPDVWLLRNDAHSLYHKRSPPAKESALSKCQSCGLSCSSSLCQRCDSLLTCPPASKPSAFPSKASTHDSLAHGASLREKYPGQTQGLDRLPHLHSKSKPSTTPTSRCGFCNRPGATNTCTQCSKVSCDACLSAYHYDPCYKKSELHKFMPNNQLNYKSTQLSHLVYR
What is the function of this protein?
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049).  Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049).  Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049).  Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).
What are the official names of this protein?
Spermatogenesis-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the SPATA2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells.
Protein: NORW_ECO81
Sequence: MSNGIVIIGSGFAARQLVKNIRKQDASIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAEQFNLRLFPHTWVTDIDAEAHVVKSQNNQWQYDKLVLATGASAFVPPVPGRELMLTLNSQQEYRACETQLRDARRVLIIGGGLIGSELAMDFCRAGKMVTLIDNAASILASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGILATLDRQRCIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNADIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTERQGMVARGVDDADQLRAFVVSEDRMKEAFGLLKTLSM
What is the function of this protein?
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase.  Reduces the rubredoxin moiety of NO reductase.
What are the official names of this protein?
Nitric oxide reductase FlRd-NAD(+) reductase, Flavorubredoxin reductase, FlRd-reductase, FlavoRb reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMT1_ARATH
Sequence: MVLEKKSALLEDLIKKCGGCAVVDGGFATQLEIHGAAINDPLWSAVSLIKNPELIKRVHMEYLEAGADIVVTSSYQATIPGFLSRGLSIEESESLLQKSVELAVEARDRFWEKVSKVSGHSYNRALVAASIGSYGAYLADGSEYSGHYGENVSLDKLKDFHRRRLQVLVEAGPDLLAFETIPNKLEAQACVELLEEEKVQIPAWICFTSVDGEKAPSGESFEECLEPLNKSNNIYAVGINCAPPQFIENLIRKFAKLTKKAIVVYPNSGEVWDGKAKQWLPSQCFGDDEFEMFATKWRDLGAKLIGGCCRTTPSTINAISRDLKRR
What is the function of this protein?
Catalyzes methyl transfer from S-methylmethionine (SMM) to adenosyl-L-homocysteine (AdoMet).  SMM degradation (by HMT-1, HMT-2 and HMT-3) and biosynthesis (by MMT1) constitute the SMM cycle in plants, which is probably required to achieve short term control of AdoMet level.
What are the official names of this protein?
Homocysteine S-methyltransferase 1, S-methylmethionine:homocysteine methyltransferase 1, AtHMT-1, SMM:Hcy S-methyltransferase 1.
Protein: MOXD1_DANRE
Sequence: MSENKLFCAIVFLTSLFCSTCSQGTRFVHSAALDAERRYNIKWGFDESTITFEIEVETRGYVGFGLSPTGAMSSSDIVIGGVLNGSPYLLDYFTDSNRKVHRDPLQNYELLYGRENDTHTVLAFSRNLQTCDDNDKIITGSTVRVIWAFHAEDVGESGLVYHGMNRGRKSLRLLNPGTGPSIPAGTAFFDLQNKEVPVPHKDTTYWCQIFRFPEMKKKHHVIRIEPLIQKGHENLVHHILLYQCDSNLNKSEVNRGHECYHPNMPDSFLTCETVLFAWAIGGEGFTYPPHVGMSIGTSIDPVYVQLEIHFDNPSLQGGIVDSSGLRLYYSPSLRRYDAGVIETGVWVSLYHMLPPGMTDYITEGHCTQECLQESLDSEMPSGVHVFAVLLHAHLAGRAITARHFRQQLELQPLASDDQFDFNFQEFQPLSQERLILPGDSLITECRYNTKGRMNMTWGGLSTREEMCLSFLLYYPRVNLAKCESLPEIAGQLKFIGVTEIQEPVTTWPFVIKSPKKYSNLSFTEAMDKYKWTMKKGKSFNDIVRKLPMNVRCSKTGQDEWSIQGMIVSPPEVRSEQTSTAVVACRKDSAIQCEHSLALLLTACLLLILQTCLHL
What are the official names of this protein?
DBH-like monooxygenase protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the copper type II ascorbate-dependent monooxygenase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RECU_STAAR
Sequence: MNYPNGKPYRKNSAIDGGKKTAAFSNIEYGGRGMSLEKDIEHSNAFYLKSDIAVIHKKPTPVQIVNVNYPKRSKAVINEAYFRTPSTTDYNGVYQGYYIDFEAKETKNKTSFPLNNIHDHQVEHMKNAYQQKGIVFLMIRFKTLDEVYLLPYSKFEIFWKRYKDNIKKSITVDEIRKNGYHIPYQYQPRLDYLKAVDKLILDESEDRV
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_HYDS0
Sequence: MRKAHIFRQTKETAIDMEIDLDGSGVYQIETPVGFLNHMMESFSKHSFIDIKLKAEGDIDVSYHHLVEDVGIVLGQAISKALGDKSGINRYGFAILPMDEALVLCSLDFSGRGLFFYDRKDLRGKITEFDFELIWEFIKGFALESKATVHIKILDGHILHHIAECSIKSLAFSVRQAVAKQDKGILSTKGLL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_UNCRE
Sequence: MGAEKRINDEEAQPLTGRDRSRDSIDSTSTASISLALIDQANRSTHAGRTTPPRNFGNGEKYRDNDDDNPEGGLPPPSGAQRTPKKVSIIFWLVAALCVGGWLVAFFVFMGSPKKDSDKEVVVSGAENSTVPGVVSTGGKKVDLDGVLTGFWSPRSHEISWIPGPDGEDGLLLEQDGDENAGYLRVENIRNQKSTNKKDDAVVLMKRETFKVGARRVRPSKVWPSPDLKTVLVMSDRLKNWRHSYTGNYWLFNVETQTGEPLDPGSPDGRIQLASWSPKSDSVVFTRDNNMFIRNLSSKDVKPITTDGGVNLFYGIPDWVYEEEVFSGNSATWWDNDGKFVAFLRTNESRVPEYPVQYFIPTVGRVAHAGEEHYPNTRKIKYPKAGAPNPTVNIQFFDVEKGEVFSIEMEDDLPDHDRLIIEVIWASNGKVLVRETNRESDRLSMVLVDAKDRTAKVIRSQDFSKLDGGWIEPSQSTYFIPADPGNGRPHDGYIETVPFEGFNHLAYFTPLDNPSPVFLTSGNWEVTDAPSAVDLKRGLVYFVAAKEQPTERHVYTVRLDGSDLQPIVNTKAPAYYTISLSTGAGYALLKYEGPEIPWQKVISTPANEERFEETIENNTELAGRAKDYALPSLYYQTITIDGYTLPVVERRPPNFNPDKKYPVLFHLYGGPGSQTVSKRFKVDFQSYVASNLGYIVVTVDGRGTGFIGRKARCVVRDNLGHYEAIDQIETAKAWGKRPYVDATRMAIWGWSYGGFMTLKTLERDAGQTFQYGMAVAPVTDWQFYDSIYTERYMHTPQNNPAGYANTAVSNVTALGQTVRFMVIHGTGDDNVHYQNTLTLLDKLDVDNVGNFDVHVYPDSDHGIYFHNAYKMLHERLSDWLVNAFNGEWVKIRNPVPNKSLMRRARSLLKRMSNA
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: RL23_METNO
Sequence: MSADPRHYDVIVAPVITEKATNLSELNKVVFRVAPKATKPQIKEAVEKLFEVKVKSVNTLVTKGKTKMFRGQRGQRSDVKKAIVTLEEGQTIDVTTGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: XYL1_ASPFU
Sequence: MTTPSIKLNSGYDMPLVGFGLWKVNKETCADQIYHAIKAGYRLFDGACDYGNEVEAGKGVARAIQEGIVKREELFIVSKLWNSFHDGDRVEPICRKQLADWGLDYFDLFIVHFPIALKYVDPAVRYPPGWLSENNKLEFSNASIQETWTAMESLVDKKLARSIGVSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQERLVTYAQKEGIAVTAYSSFGPLSFVELDLKDAHETPKLFDHDVIKGIAQKHGRTPAQVLLRWATQRNIAVIPKSNDPTRLAQNLDVTGWDLEASEIEAISALNRNLRFNDPLAIPVV
What is the function of this protein?
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol.  Xylose is a major component of hemicelluloses such as xylan.  Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
What are the official names of this protein?
Probable NAD(P)H-dependent D-xylose reductase xyl1, XR.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: YJHX_SALHS
Sequence: MNLSRQEQRTLHVLAKGGRITHIRDASGRVTAVECYSREGLLLADCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRAQPDNR
What are the official names of this protein?
UPF0386 protein YjhX.
What is the protein family that this protein belongs to?
Belongs to the UPF0386 family.
Protein: PEPT_STRE4
Sequence: MTYETLLERFLNYVKINTRSNPASTTTPSTKSQADFALTVLKPEMEAIGLQDIHYNPANGYLIGSLPANSSKLTRKIGFIAHMDTADFNAEGVAPQIIESYQGGEIKLGQSGYSLCPEDFPNLNQYLGQTLITTDGTTLLGADDKSGIAEIMTAIEFLVANPQIEHCDIKVAFGPDEEIGVGADKFDVNAFDVDFAYTIDGGPLGELQYETFSAAALELKVLGRNVHPGTAKNQMINALQLAMDFHSQLPVDDRPEKTDGYQGFYHLHSMSGTVEEAQASYIIRDFEDSSFEARKAFVTQLAEEMNSQLGAERVFVTVTDQYYNMKKVIEKDMTPVNLAKAVMEDLAIKPVIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEFVSLQTMEKAVDVILGIVQKA
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMPA_MYCTU
Sequence: MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINYAAGSPLAAILLGLLHDGVPVAGLTWMPFTDPRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFSADSRGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWTPASRSALAGPPRVHAQILEILGSIGEPEDY
What is the function of this protein?
Catalyzes the dephosphorylation of inositol 1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria.
What are the official names of this protein?
Probable inositol 1-monophosphatase ImpA, I-1-Pase, IMPase, Inositol-1-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
Protein: YO14_BPHC1
Sequence: MLYPICIEKVNDGYVVSVPDVPGCFSAGDTLSEAMLNAKEAISFHIEGMLEDDEELPKSNPIEQYINQPEYKDFIVTVVDVDLTHLMGKAEKINITVPALLLHRIDQFIATHPEYKNRSNFLSQLATNRLLSA
What are the official names of this protein?
Uncharacterized 14.9 kDa protein in rep-hol intergenic region, ORF14.
What is the protein family that this protein belongs to?
To E.coli ydcQ.
Protein: SUCB1_MOUSE
Sequence: MAASMFYGRQLAAAALRSHRPQTTLRAAAQVLGNSGLFNKHGLQVQQQQQRTLSLHEYLSMELLQEAGVSVPKGFVAKSSDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFTSGLKGGVKIVFSPEEAKAVSSQMIGQKLITKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSAQGGVNIEDVAAENPEAIVKEPIDIVEGIKKEQAVTLAQKMGFPSNIVDSAAENMIKLYNLFLKYDATMVEINPMVEDSDGKVLCMDAKINFDSNSAYRQKKIFDLQDWSQEDERDKEAANADINYIGLDGSIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVQQVTEAFKLITSDKKVQAILVNIFGGIMRCDVIAQGIVMAVKDLEIRIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAAKMVVKLSEIVTLAKEAHVDVKFQLPI
What is the function of this protein?
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, ATP-specific succinyl-CoA synthetase subunit beta, A-SCS, Succinyl-CoA synthetase beta-A chain, SCS-betaA.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PA2B2_BUNMU
Sequence: MLIFLWCGAVCVSLLGAANIPPHPLNLINFMEMIRYTIPCEKTWGEYADYGCYCGAGGSGRPIDALDRCCYVHDNCYGDAEKKHKCNPKTQSYSYKLTKRTIICYGAAGTCARIVCDCDRTAALCFGNSEYIERHKNIDTKRHCR
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 beta-bungarotoxin A2 chain, Beta-BuTX A2 chain, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: METXA_COREF
Sequence: MPQLAPEGQLATQQIGDIRTEAGALIPDVTIAYHRWGEYEENADGSTNVVLIEHALTGDSNAADWWCDLVGPGKAIDTDLYCVICTNVLGGCNGSTGPSSQHPDGGFWGSRFPATDIRDQVKAEKQFLDAIGITRVKAVLGGSMGGARTLEWAAMFPDVVDAAAVLAVSARASAWQIGIQSAQIMAIENDHHWHEGNYYESGCNPSKGLGAARRIAHLTYRGELEIDERFGTQPQKGENPLGPYRRPDQRFAVESYLDHQADKLVKRFDAGSYVTLTDALNRHDIGRGRGGLNKALESITIPVMVAGVDTDILYPYHQQEHLSRNLGNLLAMAKIVSPVGHDAFLTESRQMDRILRNFFSLISPDEDNPSTYIEFFI
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFLA_STAAB
Sequence: MLKGHLHSVESLGTVDGPGLRYILFTQGCLLRCLYCHNPDTWKISEPSREVTVDEMVNEILPYKPYFDASGGGVTVSGGEPLLQMPFLEKLFAELKENGVHTCLDTSAGCANDTKAFQRHFEELQKHTDLILLDIKHIDNDKHIRLTGKPNTHILNFARKLSDMKQPVWIRHVLVPGYSDDKDDLIKLGEFINSLDNVEKFEILPYHQLGVHKWKTLGIAYELEDVEAPDDEAVKAAYRYVNFKGKIPVEL
What is the function of this protein?
Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
What are the official names of this protein?
Pyruvate formate-lyase-activating enzyme, PFL-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the organic radical-activating enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHHA_ASPNC
Sequence: MAPSQQEKYDIVIVGAGPVGIVLSLCMSRWGYKVKHIDNRPVPTATGRADGIQPRSTEILRNLGLKRQIMAFKPAKVYDVAFWDPLPGGQGIHRTGSWPSCPRFIDTRYPFTTLVHQGKIERVFLDEIQKAGTTVERPWTIVGFKNDGLDETYPVEVQLKSIDTNVIETVRTKYLFSGEGARSFIRQQLGIQIQYKDPISYVWGVMDGVVRTNFPDIETKCTIHSDAGSIMVIPREDNMVRLYVQIASSDDPDFDPRKTATAEDVQATARKILQPYWVEWDRVEWYSVYPIGQGISEKYTLDERVFMGGDACHTHSPKAGQGMNTAFHDALNMAWKLHAVESGLAKRSILSTYETERKDIAETLLSFDNKYAALFSKRRPTAGEVGEASHTTAAAGGEEDEFVKTFKSSCEFTSGYGVAYKPNVFTWDATHPAQSPLFDVPGVRLTPGRAFTPTTVTRLADSNHVHLEQEIPANGAFRIFIFAGKQDKTSKAITDLAANLEKERSFLSVYRRADIADVSFFENHLPHSKLFSICLVYAGEKNQIDVDSIPKILRDYHHHLYADNIPDVRVPQATYAAHEKLGFDVEKGGVVVTRPDSHVACTVQLSEGSGTVDALNAFFGSFATKPLGQDSQQSRL
What is the function of this protein?
FAD-dependent monooxygenase; part of the benzoic acid degradation pathway also known as the protocatechuic acid pathway (Ref. 2).  Benzoic acid debradation begins with the conversion of benzoic acid into 4-hydroxybenzoic acid through hydroxylation by the benzoate-4-monooxygenase bphA, and its partner NADPH-cytochrome P450 reductase cprA which act as a mediator in electron donation from NADPH (By similarity).  4-Hydroxybenzoic acid is then converted into 3,4-dihydroxybenzoic acid (also called protocatechuic acid) by the p-hydroxybenzoate-m-hydroxylase phhA (Ref. 2).  Protocatechuic acid is converted into 3-carboxy-cis,cis-muconic acid by the intradiol ring-cleavage dioxygenase prcA, which is further metabolized through the 3-oxoadipate pathway to finally enter the tricarboxylic acid cycle (TCA) (Ref. 2).
What are the official names of this protein?
p-hydroxybenzoate-m-hydroxylase A, 4-hydroxybenzoate-3-monooxygenase phhA, FAD-dependent monooxygenase phhA.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HVOR_PROVU
Sequence: MINGWTGNILRINLTTGAIS
What is the function of this protein?
Oxidoreductase with an extremely broad substrate specificity that can reduce reversibly 2-oxocarboxylates to (2R)-hydroxycarboxylates.
What are the official names of this protein?
2-oxo-acid reductase, (2R)-hydroxycarboxylate-viologen-oxidoreductase, HVOR.
What is the protein family that this protein belongs to?
Belongs to the AOR/FOR family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: EFTU_LACPL
Sequence: MAKEHYERTKPHVNIGTIGHVDHGKTTLTAAITKVLASKGLAKEQDFASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVDYIVVFLNKTDLVDDDELVDLVEMEVRELLSEYDFPGDDIPVIRGSALKALEGDPEQEKVIMHLMDVVDEYIPTPVRDTEKPFLMPVEDVFSITGRGTVASGRIDRGTVKVGDEVEIVGLHEDVLKSTVTGLEMFRKTLDLGEAGDNVGALLRGVNREQVVRGQVLAKPGSIQTHKKFKGEVYILSKEEGGRHTPFFSNYRPQFYFHTTDITGVIELPDGVEMVMPGDNVTFTVELIQPAAIEKGTKFTVREGGHTVGAGVVSEIDD
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOA_DESHY
Sequence: MSDNFAAVGIALVVAIAINLIMMLMPKLLAPKKPVPEKLTPYEGGNQTIGRTWLGFKSNYFLYALVFTAFDVETVFLFPWALSFRQLGTFAFIEMFVFIVILLVGFWYAWKEGALEWM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AZI2_MOUSE
Sequence: MDTLVEDDICILNHEKAHRREAVTPLSAYPGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKAYHAYREVCIDRDNLKNQLEKINKDNSESLKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLKIHGLEQELGLLRKECSDLRTELQKARQTGPPQEDILQGRDVIRPSLSREEHVPHQGLHHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKKACTPVGCVEDLGRDSTKLHLTNFTATYKRHPSLSPNGKAPCYAPSSPLPGDRKVFSDKAVLQSWTDNERLVPNDGADFPEHSSYGRNSLEDNSWVFPSPPKSSETAFGENKSKILPLSNLPPLHYLDQQNQNCLYKS
What is the function of this protein?
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity.  Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization.  Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1.  Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B.  Participates in IFNB promoter activation via TICAM1.
What are the official names of this protein?
5-azacytidine-induced protein 2, NF-kappa-B-activating kinase-associated protein 1, Nak-associated protein 1, Nap1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B3A2_RAT
Sequence: MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEEDELRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEVGEAEGFRAPPQQPSPASSPSAVQFFLQEDEGTDRKAERTSPSPPTQTPHQEAAPRASKGAQTGTLVEEMVAVASGTAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGREPGPTPRARPRAPHKPHEVFVELNELQLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKEFSFPRNISAGSLGSLLGHHHAQGTESDPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVIFCLLGAQPLLVIGFSGPLLVFEEAFFSFCKSNQLEYLVGRVWIGFWLVLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSVSNDSEADSSSNNMTWAATTLAPDNSSASGQERPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDECEGVDEYNEMPMPV
What is the function of this protein?
Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:2371270).  Plays an important role in osteoclast differentiation and function (By similarity).  Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity).  Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).
What are the official names of this protein?
Anion exchange protein 2, AE 2, Anion exchanger 2, Band 3-related protein 2, B3RP-2, Non-erythroid band 3-like protein, Solute carrier family 4 member 2.
What is the protein family that this protein belongs to?
Belongs to the anion exchanger (TC 2.A.31) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FRIH_CHICK
Sequence: MATPPSQVRQNYHQDCEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWENGLTAMECALHLEKNVNQSLLELHKLATEKNDPHLCDFIETHYLDEQVKAIKQLGDHVTNLRKMGAPKYGMAEYLFDKHTLGESDS
What is the function of this protein?
Stores iron in a soluble, non-toxic, readily available form.  Important for iron homeostasis.  Has ferroxidase activity.  Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.  Also plays a role in delivery of iron to cells.  Mediates iron uptake in capsule cells of the developing kidney (By similarity).
What are the official names of this protein?
Ferritin heavy chain, Ferritin H subunit.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.