PharMolix/UniProtQA huggingface dataset:
Protein: PSAB_GUITH
Sequence: MATKFPKFSQALAQDPATRRIWYGLATAHDFESHDGMTEENLYQKIFASHFGHLAIIFLWTSGNLFHVAWQGNFEQWVLNPLKVKPIAHAIWDPHFGQPAVKAFTKGGVSYPVNIATSGVYHWWYTIGMRTNNDLYSGSIFLLILASVMLFAGWLHLQPKFRPGLAWFKNNESRLNHHLSGLFGFSSVAWSGHLIHVAIPESRGLHVGWDNFTKVYPHPEGLKAFFTGNWSNYAANPDTADHIFGTTEGSGTAILTFLGGFHPQTQSLWLTDIAHHHLAIGVIFIFAGHMYRTNWGIGHSLKEILDAHRAPSGRLGNGHKGLFETISNSLHFQLGLALASLGVITSLVAQHMYALPSYAFIAKDYVTQAALYTHHQYIAGFLMVGAFAHGAIFFVRDYDPEQNKNNVLARMLEHKEAIISHLSWVSLFLGFHTLGLYVHNDVVVAFGTPEKQILVEPVFAQWIQASSGKAMYGFDVLLSANTSIAKNASSNIWLPGWLEAINSGKNSLFLPIGPGDFLVHHAIALALHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLSMFWMLNTIGWVTFYWHWKHVTIWQGNAGQFNESSTYIMGWLRDYLWLNSSPLINGYNPFGMNSLSVWAWMFLFGHLIWATGFMFLISWRGYWQELIETLVWAHERTPLANLVRWRDKPVALSIVQARLVGLVHFTVGYIFTYAAFVIASTAGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RNY_BACCR
Sequence: MTSTVWILISILLATVGAVVGFFVRKSIAEAKINGAANEARRILDGANRDAEALKKEALLEAKDEIHTLRTEAELEIRDRRSELQKQENRLMQKEENLDRKDETLDKREQQLEKKEESLVARQQQIEELESKVGELVQKQQTELERISNLTREQAKAIILGKVESEVSHEIAVMVKESEVRAKEEADKKAKEILSLAMQRCAADHVAETTVSVVNLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQDGRIHPARIEEMVEKSRREVDEYIREVGEQTTFEVGVHGLHPDLIKILGRLKYRTSYGQNVLKHSMEVAYLTGLMAAELGEDEKLARRAGLLHDIGKAIDHEVEGSHVEIGVELATKYKEHPVVINSIASHHGDTEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEEISESYEGVEKSFAIQAGREVRILVKPDTIDDLEAHRLARDIRKRIENELDYPGHIKVTVIRETRAVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: IBPA_ECO7I
Sequence: MRNFDLSPLYRSAIGFDRLFNHLENNQSQSNGGYPPYNVELVDENHYRIAIAVAGFAESELEITAQDNLLVVKGAHADEQKERTYLYQGIAERNFERKFQLAENIHVRGANLVNGLLYIDLERVIPEAKKPRRIEIN
What is the function of this protein?
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpA, 16 kDa heat shock protein A.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SQS11_PANGI
Sequence: MGSLGAILKHPEDFYPLLKLKIAARHAEKQIPSEPHWAFCYSMLHKVSRSFGLVIQQLGPQLRDAVCIFYLVLRALDTVEDDTSISTEVKVPILMAFHRHIYDNDWHFSCGTKEYKVLMDEFHHVSNAFLDLGSGYKEAIEDITMRMGAGMAKFICKEVETIDDYDEYCHYVAGLVGLGLSKLFHASGAEDLATDSLSNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPRQIWSKYVDKLEDLKYEENSAKAVQCLNDMVTDALVHAEDCLKYMSDLRGPAIFRFCAIPQIMAIGTLALCFNNTQVFRGVVKMRRGLTAKVIDQTKTMSDVYGAFFDFSCLLKSKVDNNDPNATKTLSRLEAIQKICKNSGALTTKRKSYIIENESGYNSTLIIILFIILAILYAYLSSNLPNSL
What is the function of this protein?
Component of the triterpene saponins (e. g.  ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:29378087).  Catalyzes the biosynthesis of squalene (By similarity).
What are the official names of this protein?
Squalene synthase 11, PgSS11, SQS 11, FPP:FPP farnesyltransferase SS11, Farnesyl-diphosphate farnesyltransferase SS11.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RUTB_ECOK1
Sequence: MPRPSPCADSGGGMMTTLTARPEAITFDPQQTALIVVDMQNAYATPGGYLDLAGFDVSTTRPVIANIQTAVTAARTAGMLIIWFQNGWDEQYVEAGGPGSPNYHKSNALKTMRNQPLLQGKLLAKGSWDYQLVDELVPQPGDIVLPKPRYSGFFNTPLDSILRSRGIRHLVFTGIATNVCVESTLRDGFFLEYFGVVLEDATHQAGPEFAQKAALFNIETFFGWVSDVETFCDALSSTSFARIA
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: ASSY_ECOLC
Sequence: MTTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLHSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRRGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQVENLENKGQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSD_YERPG
Sequence: MLNRLESLTQRVGGSNELIDQWLHARKELLVSYCTVIGIKPQKEKHTPLNAKTLENFCHNLVDYLSSGHFHLYDRIIKEVEGASSPKMALTAKIHPALKNNTQTIMAFHDCYTNIEIDDDSCTEYQQALSDIGEALDARFRLEDQLIQWAAESWQAAQLADADKKSQVN
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBL_PROMA
Sequence: MQVNPNPNKLSVELNRTSLYLGLLLVFVLGILFSSYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: COF_SALDC
Sequence: MARLAAFDMDGTLLMPDHHLGRETIATLARLRERDITLTFATGRHVLEMRHILGTLSLDAYLITGNGTRIHSLEGDVLHRQDLDPQVADTVMHHAWDTRASMHVFNDNGWFTGQEIPALLQAHVYSGFRYQVIDIKSIPAHQVTKICFCGDHDDLIRLRIQLNEALEERAHLCFSAVDCLEVLPLGCNKGSALAVLSNHLGLSLADCMAFGDAMNDREMLGSVGRGLIMGNAMPQLIAALPHLSVIGHCGNQAVSHFLTHWLDNPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: CTPD_MYCTO
Sequence: MTLTACEVTAAEAPFDRVSKTIPHPLSWGAALWSVVSVRWATVALLLFLAGLVAQLNGAPEAMWWTLYLACYLAGGWGSAWAGAQALRNKALDVDLLMIAAAVGAVAIGQIFDGALLIVIFATSGALDDIATRHTAESVKGLLDLAPDQAVVVQGDGSERVVAASELVVGDRVVVRPGDRIPADGAVLSGASDVDQRSITGESMPVAKARGDEVFAGTVNGSGVLHLVVTRDPSQTVVARIVELVADASATKAKTQLFIEKIEQRYSLGMVAATLALIVIPLMFGADLRPVLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVVERLADTSIVALDKTGTLTRGIPRLASVAPLDPNVVDARRLLQLAAAAEQSSEHPLGRAIVAEARRRGIAIPPAKDFRAVPGCGVHALVGNDFVEIASPQSYRGAPLAELAPLLSAGATAAIVLLDGVAIGVLGLTDQLRPDAVESVAAMAALTAAPPVLLTGDNGRAAWRVARNAGITDVRAALLPEQKVEVVRNLQAGGHQVLLVGDGVNDAPAMAAARAAVAMGAGADLTLQTADGVTIRDELHTIPTIIGLARQARRVVTVNLAIAATFIAVLVLWDLFGQLPLPLGVVGHEGSTVLVALNGMRLLTNRSWRAAASAAR
What is the function of this protein?
Involved in heavy metal homeostasis.  Probably exports nickel and cobalt ions out of the cell (By similarity).
What are the official names of this protein?
Probable cobalt/nickel-exporting P-type ATPase, Cation-transporting P-type ATPase CtpD.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACYP_AERS4
Sequence: MGEQSFVVHVWGQVQGVGFRYFTRERALQLGLRGYAYNLADGSVEILICGPEQGVQMMLGWLEHGPRTAEVTRMEYEEAPPPQKGGFHTN
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: H2B_NEUCR
Sequence: MPPKPADKKPASKAPATASKAPEKKDAGKKTAASGDKKKRTKARKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PANC_SALSV
Sequence: MLIIETLPLLRQHIRRLRQEGKRVALVPTMGNLHDGHMKLVDEAKARADVVFVSIFVNPMQFDRPDDLVRYPRTLQEDCEKLNKRKVDYVFAPAVEEIYPQGLEGQTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLIQPDIACFGEKDFQQLALIRKMVADMSYDIEIVGVPIIRAKDGLALSSRNSYLTAEQRKIAPGLHNVMNSIAEKLIAGNRELQEIIAIAEQELNEKGFRADDIQIRDADTLLELTETSKRAVILAAAWLGQARLIDNQSVTLAQ
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNBI_GAHVM
Sequence: MDGVGKSVKLCGGPIGYIYATPKCSVPVDELAILAAKSNDCDDAVLPLVAGLTVESDFVWNVAAVAGTKTTGLGSGGTTLKLVPTHYHPCVFVFYGGDCIKPCTKAPNLTKACDLARERFGYSAYSSPAPTAFETTGQQICEALEMDAQNVMLYLVVTELFKEVIYLCNSFLHFGGSDVVTINNADVRRIPIYPLHLVLPDFNRITNEPFSEKPRALGEGAIMPKAFYNDSLCRLLHGYVLSTTAVGLRVRNIDAIARGAAHLCFDENHEGTLLPADTTFTAFTPAAETTKGQSKMGKREGSDVSGGGYERRTASLMASDATLAIENVISASVYEDPIPDVNKWPIYCNPVGYADRIEALSAYMARVAGLVGAMVFSSNSVIYMTEVGEAGSTEGKETSTTAPSFYRFFQIAAPHLSANPLVDRDGKPVSGENLSKSTSASQSEYSLDYLILACGFCPQLLARFLFYLERCDGGAKACHHDLDTVKFVSSAIDADMPCELCDKTSRIYCAHTTIKRLVYRLPKFGYQMRGAMGLFGAMTNNYCDVNALGSYAQFSTLKRSEGEASRSVMQDTYRLTVERMMKALEKEGLLTCDDPTNMASADANIRDGNSFIRAISTMKNIIESEASQLMRNLTEIREYNIREGLGDANHTLSLAVEPYASGICPVLAFLSRRTIIAVVQDMALSQCSIVMQGQQVEARNFRTQFQAVLKRRVLELQNAGFITSKTITVTLEDQQICVPDPSKSQYDSVISNMEGDLVKVTVEIFRELKVKNKVLFGGGIAGAASEATKSRLAGMVEAYQRPTKTMHVLNGPLGFAVKRYHTLLFPDVKMPNGATPNALWFWILLLRNQLPAGILSKEEEDKSLFIKKFTKSYADMNYINISPTCFGDLAQFYLANTILKYCSHKHFFINTISALVAVSRRPRDPAIVLPWIERPITKGQDVAPAAQQLIASMSDHKDIWCATFSSTNLVGSIMTTKPFVVIGISISKYHGMAGSTKVFQSGNWGNIMGGRNVCSLMSFDRTHRYVMTCPRVGFVAEQPIFSSGIKETTLIDRVRMVLSEESAAPHAAVYMLALKMVGDRVRQMELEDWMEITNDEYISSLIDELNKQVEEAEGGWNADAAMTLAKEMVNMAMSIPTDGPTFDFDACDENLEGHADGQTISETNLKRPNMNVFDLEPIPEKRVPVLSVDML
What is the function of this protein?
Plays several crucial roles in viral infection.  Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.  Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle.  Can also catalyze the renaturation of complementary single strands.  Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments.  This process is driven by the protein which can form double-helical filaments in the absence of DNA.
What are the official names of this protein?
Major DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework- associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Protein: ATPL_SYNSC
Sequence: MDSITSAASVVAAGLAVGLAAIGPGIGQGTASGGAVEGIARQPEAEGKIRGTLLLSLAFMESLTIYGLVVALVLLFANPFAG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: MIAA_SALPA
Sequence: MNDVSKASLPKAIFLMGPTASGKTALAIELRKVLPVELISVDSALIYRGMDIGTAKPNADELKAAPHRLLDIRDPSQAYSAADFRRDALAQMAEITSAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRSRIEQQAAELGWEALHQQLQEIDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIELRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYIEGEISYDEMVYRGVCATRQLAKRQMTWLRGWEGGRWLDSENPDRARKEVLQVVGAIAD
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: NOTJ_ASPVE
Sequence: MRNMATMLHLLTLILLTSPASTQTANAVPKRRLIGEDRESGRRWGVAATDLGIPYDMHNGQVGYLFGDTVSTMWVQEAKDLRSPVMLLSGIHPGEDGGIFFESAAGVDGDGLAPRLFYNGDHGDDGTGTWEFTVLPNDGISFPETGEHIISYTSIMNFTTSWTPNYAGLAYSTDGNSFSRLPTKWLNNDNNTDPFQMWTMQRDGDWVYVFTVRCARQYGPMMLQRVPWDKMTDKTEYQGWGWNGEDWGWQRPCSPILDGYFGEPSVRRLQDGTWAMVYLNASTSTPHIVSRTARGPTGPWSEETVQVNQAGDESLLYGGFIHPWSTGERNQLYLMVSNWTSTSDAAPTPEGLVSVSQFTGTL
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of notoamide, a fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2. 2. 2]diazaoctane core (PubMed:23213353).  The first step of notoamide biosynthesis involves coupling of L-proline and L-tryptophan by the bimodular NRPS notE', to produce cyclo-L-tryptophan-L-proline called brevianamide F (Probable).  The reverse prenyltransferase notF' then acts as a deoxybrevianamide E synthase and converts brevianamide F to deoxybrevianamide E via reverse prenylation at C-2 of the indole ring leading to the bicyclo[2. 2. 2]diazaoctane core (PubMed:22660767) (Probable).  Deoxybrevianamide E is further hydroxylated at C-6 of the indole ring, likely catalyzed by the cytochrome P450 monooxygenase notG', to yield 6-hydroxy-deoxybrevianamide E (Probable).  6-hydroxy-deoxybrevianamide E is a specific substrate of the prenyltransferase notC' for normal prenylation at C-7 to produce 6-hydroxy-7-prenyl-deoxybrevianamide, also called notoamide S (Probable).  As the proposed pivotal branching point in notoamide biosynthesis, notoamide S can be diverted to notoamide E through an oxidative pyran ring closure putatively catalyzed by either notH' cytochrome P450 monooxygenase or the notD' FAD-linked oxidoreductase (Probable).  This step would be followed by an indole 2,3-epoxidation-initiated pinacol-like rearrangement catalyzed by the notB' FAD-dependent monooxygenase leading to the formation of notoamide C and notoamide D (Probable).  On the other hand notoamide S is converted to notoamide T by notH' (or notD'), a bifunctional oxidase that also functions as the intramolecular Diels-Alderase responsible for generation of (-)-notoamide T (Probable).  To generate antipodal (+)-notoaminide T, notH (or notD) in Aspergillus strain MF297-2 is expected to catalyze a Diels-Alder reaction leading to the opposite stereochemistry (Probable).  The remaining oxidoreductase notD' (or notH') likely catalyzes the oxidative pyran ring formation to yield (-)-stephacidin A (Probable).  The FAD-dependent monooxygenase notI' is highly similar to notB' and is predicted to catalyze a similar conversion from (-)-stephacidin A to (+)-notoamide B via the 2,3-epoxidation of (-)-stephacidin A followed by a pinacol-type rearrangement (Probable).  Finally, it remains unclear which enzyme could be responsible for the final hydroxylation steps leading to notoamide A and sclerotiamide (Probable).  The fonction of notJ' in the notoamide biosynthesis has not been determined yet (Probable).
What are the official names of this protein?
Notoamide biosynthesis cluster protein J'.
Protein: MMAB_HUMAN
Sequence: MAVCGLGSRLGLGSRLGLRGCFGAARLLYPRFQSRGPQGVEDGDRPQPSSKTPRIPKIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALELVTEKGHTFAEELQKIQCTLQDVGSALATPCSSAREAHLKYTTFKAGPILELEQWIDKYTSQLPPLTAFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSDYLFTLARYAAMKEGNQEKIYMKNDPSAESEGL
What is the function of this protein?
Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion (PubMed:12514191).  Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA (Probable).
What are the official names of this protein?
Corrinoid adenosyltransferase MMAB, ATP:co(I)rrinoid adenosyltransferase MMAB, Methylmalonic aciduria type B protein.
What is the protein family that this protein belongs to?
Belongs to the Cob(I)alamin adenosyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SSUD_PECCP
Sequence: MSLNVFWFLPTHGDGRYLGSTEGARHVDYGYLQQVAQAAERQGFGGVLLPTGRSCEDSWLVAASLIPVTQRLKFLVALRPGVISPTIAARQAATLDRLSNGRALFNLVTGGDPEELAAEGLFLSHEERYEASAEFTHIWRRLLEGETVDFAGKHIQVKDAKLLYPPVQQPRPPLYFGGSSEAAQNLAAEQVDLYLTWGEPPEQVKEKLAEVRDKAAAQGREVRFGIRLHVIVRETTEEAWQAADRLISHLDEKTIADAQAALARFDSVGQQRMAALHGGKKDKLEISPNLWAGIGLVRGGAGTALVGDGPTVAERIQEYADLGIDTFILSGYPHLEEAYRVGELLFPHLDLAQQPTPLHAVNNAGEVVANRYVPRKVSQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: IKBE_MOUSE
Sequence: MSDARKGPDEADDSQCDSGIESLRSLRSLPEPTAAPGSGSSQSGCPQPWRHAPETHKEPEKEDADGERADSTYASSSLTESFPLLERPEAKDPSPPAPGSPLPPAGVLSPQQLEALTYISEDGDTLLHLAVIHEAPSVLFCCLAFLPQEVLDIQNNLYQTALHLAVHLDQPDVVRALVLKGASRILQDQHGDTALHVACRRQNLACACCLLEEQPEPGRQLSHPLDLQLKNWQGLACLHIATLQRNQPLIELLLQNGADIDVQEGTSGKTALHLAVETQERSLVQFLLQAGARVDARMLNGCTPLHLAAGRGLNSISSTLCEAGADSLLLNVEDETPQDLAEDLLSYLPFDDLKISGKPLLCTD
What is the function of this protein?
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm.  Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes (By similarity).
What are the official names of this protein?
NF-kappa-B inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon.
What is the protein family that this protein belongs to?
Belongs to the NF-kappa-B inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_SOLLC
Sequence: FIMIKPDGVQRGLVGEIISRFEKKGFSLKGLKLITVDRAFAEKHYADLSAKPFFNGLVEYIVSGPVVAMVWEGKGVVATGRKIIGATNPLESAAGTIRGDFAIDIGRNVIHGSDAVESARKEIALWFPEGIAEWQSSLHSCIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
Protein: DNJC2_XENTR
Sequence: MLIEAQAEQCTFVTRGLCAAAVLCQVEPVGRWFEAFIKRRNRNVSASFQELEDEKESSEESEDEEFQLEEFPLLKTLDPKDWKNQDHYAVLGLKNLRYKATQRQIKAAHKAMVLKHHPDKRKAAGEQIVEGDNDYFTCITKAYEILSDPIKRRAFNSIDPTFDNSIPSKSEGKDNFFDAFSPVFERNSRWSNKKNIPKLGDMNSCIEEVDGFYSFWYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNRAARAQRKKEEMIRIRTLVDNAYSSDPRIKKFKEEEKARKEAEKKAKADARRKEQEEKERQKQAELEAVRLAKEKEEEEARQQALLIKKEKEIQKKAIKKERQRLRTSCKNWNYFSDNEAESVKMMEEIEKLCDRLELASLQSLNESLAVSSKEEGKSAVEKQIAEVNAQLKREKEQEEARMKQSTKGAENSAIGGGSGSKSWSEDDLQLLIKAVNLFPAGTNARWEVIANYMNLHSISGIKRTSKDVINKAKSLQKLDPQQKDDINKKAFDKFKKEHRVVPQSVDNAVPSERFEGPAADMSPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRSKKDCMKRYKELVEMVKAKKAAQEQVLNATKIKK
What is the function of this protein?
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus.  When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.  When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).
What are the official names of this protein?
DnaJ homolog subfamily C member 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: IBP_WIGBR
Sequence: MDNLFSRITGEQPLSENPNYNLIQLDKYNYELSVSVPGYKKEELEVSIINNRLNINSKSKKEKEKETKKINWIHQGILKNNFSISFKLEHKIKIKYANLKHGILNLSFFYDLPDQEKPKKISINEEHDHKCNI
What are the official names of this protein?
Small heat shock protein ibp.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: RLA2_BRUMA
Sequence: MMKYLAAYLLSTMSGNKSPSAKDIEDVLGSVGLDVDMEDANKVVSALSGKSIDEVITAGLAKVSSVPSDAAVSAIAPVVSATPTDALQAGSKKGETKEGPKEESDEDMGFGLFD
What is the function of this protein?
Plays an important role in the elongation step of protein synthesis.
What are the official names of this protein?
60S acidic ribosomal protein P2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.