PharMolix/UniProtQA huggingface dataset:
Protein: PAND_PHOLL
Sequence: MLRTMLQGKLHRVKVTQADLHYEGSCAMDQNFMDAAGILEYEAIDIYNVDNGERFSTYAIAAERGSRIISVNGAAARRAAVGDKLIICSYVQIPNEDARHHKPNIAYFDGDNIMRRIAKAVPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_LACLM
Sequence: MLKPLENRVVLRVKEEEEKSMGGIVLTSASQEKPQTAEVIAVGEGKTTNHGTLISPLVKVGDTVIFEKFAGTTVKMDGEEFLILKDSDLLAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_BACAH
Sequence: MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVVAAVEELKTISKPIEGKSSIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKMEAVLDNPYILITDKKISNIQEILPVLEQVVQQGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGKVVVTKENTTVVEGVGSTEQIEARIGQIRAQLEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNVYTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATGEWVNMLETGIVDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_SALEP
Sequence: MIKKIGVLTSGGDAPGMNAAIRGVVRAALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIRAVAIENLKKRGIDALVVIGGDGSYMGAKRLTEMGFPCIGLPGTIDNDIKGTDYTIGYFTALGTVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFIVVPEVEFNREDLVAEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLEGHGGRCVGIQNEQLVHHDIIDAIENMKRPFKSDWMECAKKLY
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOA2_NASLA
Sequence: MKLLAATVLLLTICSLEGALVRRQAEEPSVESLVSQYFQTVTDYGKDLMEKVKSPELQAQAKAYFEKSKEQLTPLVKKAGTDLVNFLSYFVELRTQPATQ
What is the function of this protein?
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
What are the official names of this protein?
Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YKZF_BACSU
Sequence: MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTKNVDGTTYKKLVTLYDRFRFEN
What are the official names of this protein?
Uncharacterized protein YkzF.
Protein: Y3769_VARPS
Sequence: MPSFDTVCEPNLPEVKNAVENTAKEIATRFDFKGTAAAVELKDKEITMIGDAEFQLVQVEDILRAKLTKRSVDVRFLDKGDVQKIGGDKVKQVIKVKSGIESEQAKKITRIIKDSKLKVQAAIQGDAVRITGAKRDDLQAAMALIKKDVPDMPLSFNNFRD
What are the official names of this protein?
UPF0234 protein Vapar_3769.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: BETI_PARXL
Sequence: MPKLGMREIRRAQLIDATLLTIDQTGLAGTTLASVAQRASISTGIVSHYFGDKDGLLEATMRHVLRDLWQATSRRRRAARADPRSKLRAVVAANFDAEQTSGPVMKTWLAFWSESMHKPQLRRLQHVNTRRLYSNLCADFSKALPRAAARRAASGLAALIDGLWLRGALSGEPFDTKAALRTANDYIDLVLASRE
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: RL22_DEHM1
Sequence: MEVKAIVKDTGYSALKVRLCVDMVRGKKVSEAITMLRFMTSPTAKVVSKVIKSAAANAENNFQMNPADLKISQIYADEARMLKRMRPQARGRVSPILKRSSHITVVVAD
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RBL_NEODN
Sequence: MSQSVESRTRIKSERYESGVIPYAKMGYWDADYVIKETDILALFRITPQPGVDPIEASAAIAGESSTATWTVVWTDLLTACDLYRAKAYRVDPVPNVADQYFAYIAYDIDLFEEGSIANLTASIIGNVFGFKAVKALRLEDMRMPVAYLKTFQGPATGLIVERERMDKFGRPFLGATVKPKLGLSGKNYGRVVYEGLKGGLDFLKDDENINSQPFMRWRERFLYSMEGVNKASASAGEIKGHYLNVTAATMEDMYERAEFSKEVGSIICMIDLVIGYTAIQSMAIWARKHDMILHLHRAGNSTYSRQKNHGMNFRVICKWMRMAGVDHIHAGTVVGKLEGDPLMIKGFYNTLLESETDINLPQGLFFAQNWASLRKVVPVASGGIHAGQMHQLLDYLGDDVVLQFGGGTIGHPDGIQAGATANRVALESMVMARNEGRNYVAEGPQILRDAAKTCGPLQTALDLWKDISFNYTSTDTADFVETPTANI
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYY_NITOC
Sequence: MVSPQQILDEIRRGTEEVLLEEELKLRLEQGRILRVKAGFDPTAPELHLGHTVLLNKLRQFQEFGHEVLFLIGDFTGMIGDPSGKNVTRQPLTRDKILENARTYEEQIFRVLDPEKTLVVFNSSWMSGMTAADLVRLSSHYTVARMLERDDFYKRYQGKRPIAIHEFLYPLLQGYDSVALKADVELGGTDQKFNLLVGRDLQKAYGQEQQIIITMPILEGLDGVQKMSKSLGNYIGISEPPREIFGKLMSISDDLMWRYLELLSSRPMSEISRWKKEVEQGANPRDIKVKLAKEIVARFHDDSMAEQVHEAFVAQFRRGAMPEDIPEILIVAGREGIAIARLLKESALTASTSESLRLIKQGAVKIDGQRLGNQSLQILPGITHVVQVGKRRFARVSIRLSEDQCRK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYCO_RABVS
Sequence: MVPQALLFVPLLVFPLCFGKFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSGFSYMELKVGYILAIKVNGFTCTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWKMAGDPRYEESLHNPYPDYRWLRTVKTTKESLVIISPSVADLDPYDRSLHSRVFPSGKCSGVAVSSTYCSTNHDYTIWMPENPRLGMSCDIFTNSRGKRASKGSETCGFVDERGLYKSLKGACKLKLCGVLGLRLMDGTWVSMQTSNETKWCPPDKLVNLHDFRSDEIEHLVVEELVRKREECLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEILPSKGCLRVGGRCHPHVNGVFFNGIILGPDGNVLIPEMQSSLLQQHMELLESSVIPLVHPLADPSTVFKDGDEAEDFVEVHLPDVHNQVSGVDLGLPNWGKYVLLSAGALTALMLIIFLMTCCRRVNRSEPTQHNLRGTGREVSVTPQSGKIISSWESHKSGGETRL
What is the function of this protein?
Attaches the virus to host cellular receptor, inducing endocytosis of the virion.  In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane.  There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
What are the official names of this protein?
Glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: RL31_PASMU
Sequence: MKQGIHPNYVEVTATCSCGNVIKTRSTVGKDLNLDVCGNCHPFYTGKQRVVDTGGRVERFNKRFSIPSTK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: GLPK_DEIRA
Sequence: MSEHQYILALDQGTTSSRAIVFDHQGNMKGVGQQEFRQHFPKPGWVEHDANEIWSTQIGVAQQALSNAGIRASDLAAIGITNQRETTLIWDRATGKPIHHAIVWQDRRTAPYCDSIRAQHEKTLQDKTGLVLDAYFSGTKVKWLLDNVPGARERAEKGELAFGTIDSWLVYNLTGGELHITDATNASRTLLYNIHTGEWDDELLRILDVPRSVLPEVRNSSEVYGKTAAGLLGAQVPIAGIGGDQQAATFGQACLERGMAKNTYGTGCFMLMNTEGEAVPSQNKLLTTVAWQLDGERTYALEGSVFIGGAVVQWLRDGLNIIRSSTEIEALARTVDSSEGVMLVPAFVGLGAPYWDAYARGTMVGITRGTTKAHIARAALEAVAYQSAELLEAMQKDSGVELKELRVDGGASTNDLMMQFQADILGVPVIRPKVTETTALGAAYLAGLAVGYWKSTDDIAHQWQEDKRFEPQMSEEERSKLMRRWKKAVARARDWEDDSEA
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RL21_BEII9
Sequence: MFAVIKTGGKQYSVAADDIITVMTLQGEPGDAVTFDSVLMLAGEGEPKIGAPFIAGATVSGEIVEQTRGPKVISFKKRRRQNSKRKRGHRQDLTLVKITGINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: THYX_THET8
Sequence: MEGPLTIPVLDKGFVRLVDQMGDDRAIVQAARVSYGEGTKTVREDAALIDYLMRHRHTSPFEMVVFKFHVKAPIFVARQWFRHRTASVNEISGRYSILKEEFYEPEAFRKQAKRNKQASEGALLDEEALALLRKVQQEAYGAYRALLEKGVAREMARMVLPLNLYTEFYWKQDLHNLFHFLKLRLAPEAQWEIRQYARAIAEIVKERVPLAWAAFEEHLLEGAFLSRTELRALRGLLTPEVYEKALSSLGLGGSRLKEALEKVFGPGEAL
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: KAT3_BOVIN
Sequence: MFLAWERLCTLSCRPKFLKTVWASKILGLSTSAKMSLRFKNAKRIEGLDSNIWIEFTKLAADPSVVNLGQGLPDISPPVYVKEELSKIAAIDNLNQYTRGFGHPSLVKALSCLYEKFYHNKINPNEEILVTVGAYGSLFNAIQGLIDEGDEVIVIVPFFDCYESMVRMAGATPVFVPLRCKPVDGKKCSSSDWTLDPQELASKFNSKTKAIILNTPHNPLGKVYTKEELQVIADLCIKYDTLCISDEVYEWLVYTGNKHFKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPKHLIKHLQTVQQNTVYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVHLLESVGLKSIVPDGGYFIIADVSLLDVDLLDMKDSNEPYDYKFVKWMIKNKKLSAIPVSAFCNAETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSRQNS
What is the function of this protein?
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others.  May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.  Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro).  Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).
What are the official names of this protein?
Kynurenine--oxoglutarate transaminase 3, Cysteine-S-conjugate beta-lyase 2, Kynurenine aminotransferase 3, Kynurenine aminotransferase III, KATIII, Kynurenine--glyoxylate transaminase, Kynurenine--oxoglutarate transaminase III.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: WHB2B_MYCTO
Sequence: MVPEAPAPFEEPLPPEATDQWQDRALCAQTDPEAFFPEKGGSTREAKKICMGCEVRHECLEYALAHDERFGIWGGLSERERRRLKRGII
What is the function of this protein?
The apo-form functions as a chaperone, preventing aggregation or helping in correct refolding of a number of substrates.
What are the official names of this protein?
Transcriptional regulator WhiB2, Probable chaperone WhiB2.
What is the protein family that this protein belongs to?
Belongs to the WhiB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CL029_RAT
Sequence: MNRLGSVQRKMPCVFVTEVKAEPSAKREHQPFKVLATETLSEKALDADVYNAVATEKVDGTCCYVTNYKGQPYLWARLDRKPNKQADKRFKKFLHSKENAKEFHWNTEEDFKPVPECWIPAKEIEKQNGKPVPDENGHIPGWVPVEKNSKQYCWHSSVVSYEFGIALVLRHHPDDPGVLEISAVPLSELLEQTLELIGTNINGNPYGLGSKKYPLHFLTPHGAFQVRNLPTLKHNDLLSWFEGCREGQIEGIVWHCGDGCLIKVHRHHLGLCWPLPDTYMNSKPVIINMNLDKYDCAFDHQSLFNKFSKIDKQKFDRLKDITLDI
What are the official names of this protein?
Uncharacterized protein C12orf29 homolog.
Protein: YL042_MIMIV
Sequence: MDHFDQDTYHNLPVEIWKHIIDSDIDSTINLLFSCKQFIGLVCILTNNLNLLNLLVKKGNLKFLEFYFRLNTETNKLYTEQRLRVEQNECLKMSCIHGCLEILKYLISIGVDFRMNDDEPLMLAIENGHLKIVQFLYSKRVNIRARNNRPLVLSCEKGYINIVNFLLDKKASFVSKQNEVFSTACGFGQMDIVKLLVEKGADINVGKIPPIRAAAAGGHLNVIEHLVNKGASINKCSVDSLFSAAFYGHLNIVKYLLGYISEVNIIYYAFEKACINGHIDIVQYLFSENIITKDIITENSNTRYLFYHTIRNKHKHIIKFLIENNIFDKDKKYPDILESAPKDMDPYDYLISFLNYQ
What are the official names of this protein?
Putative ankyrin repeat protein L42.
Protein: VIP2_XENLA
Sequence: MSVSATENDVPRFFVGCEESDELLDQSKPENLDNLYEHTEDEEDEEDDEYDSPPERQIVVGICAMAKKSKSKPMKEILERLSLFKYITVVIFEEEVILNETVENWPLCDCLISFHSKGFLLDKAVAYAKLRNPFVINDLNLQYQIQDRREVYRILTNEGIMLPRYAVLNRDPNKPEECNLIEGEDHVEVNGEIFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRASGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIIMRELAPVFHIPWSIPLEAEDIPIVPTTSGTKMELRCVIAVIRHGDRTPKQKMKMEVRHQRFFDLFEKYHGYKTGKIKLKKPKQLQEVLDIARQLLVELGQNNDSEIEESKAKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDCRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHEILQRDRDFSSEDFEKLSPTGSVSQIKSMHFIKNPVKTCDKVYSLIQSLTSQIRQRMEDPKFADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNCSLKLENTMELYRLSKALADIVIPQEYGISRPEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPLYSRGVMSPERHVRTRLYFTSESHVHSLLSILRFGALCDETKDEQWKRAMDYLNVVSELNYMTQIVIMLYEDPNKDVSSEERFHVELHFSPGAKGCEEDKNLPSGFGYRPASQENESSKKHTHANDSDEDLGVCRRDEPDRALVMFKPMVSDPIHIHRKSPLPRSRKIGSVEVLSDNNSHLRTARLLEQKHIGLGFELYSMVPSICPLETLHNSLSLKQVDEFLSAVAAPSSDYQMDTPTASPSTPGFYTYVGGRKISLNTYTPTKILPPLFPVSTDVEMSDSVFQSCSSTSMVPGLAGSADNTERNHQAQDD
What is the function of this protein?
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4.  PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation.  Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4.  Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
What are the official names of this protein?
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, Diphosphoinositol pentakisphosphate kinase 2, Histidine acid phosphatase domain-containing protein 1, InsP6 and PP-IP5 kinase 2, VIP1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: GLOF_GLAL2
Sequence: MAIQTLDYRDFQYGGQEQHRTFCHNLCETLSTWGFIKIQNTSIPDAVIDELFSYNKKFFALPEHIKQKARHPAAPNPHRGWSAVGQEQLSRIAGFEKDEETDGFVPEYRESFDQGAADDELFPNRWIDEDDLPGFRKFMENYYEMCYNFHTQLLRAISTGLSLPEDLLLSRHQTDTSELRMNHYPAIACENLKFGMRIGEHSDFGTLTLLLQDSTGGLQVEDQKKLGTFIPVESDSRYEVIVNVGDCLQRWTNRRLRSANHRVHLPEGKNFKSDEVLADRYSVAYFGKPDRNVLVDSFPEFCRGGESKYNDHMNALEYNQTKLLRTYA
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase (PubMed:27705900).  The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4 (PubMed:27494047).  The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain (PubMed:27494047).  The 10R,12S-dimethylmyristic acid is then transferred to the first thiolation domain of the nonribosomal peptide synthetase gloA/GLNRPS4 by the acyl-AMP ligase gloD/GLligase, followed by its acylation to L-ornithine to trigger elongation of the cyclic hexapeptide (PubMed:27494047).  L-ornithine, 4R-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2), 3S-hydroxyl-L-homotyrosine (generated by gloG/GLHtyB, gloH/GLHtyA, gloI/GLHtyC, gloJ/GLHtyD and hydroxylated at C-3 by the dioxygenase gloM/GLOXY1), 3R-hydroxyl-L-glutamine (generated from L-glutamine probably by the dioxygenase gloE/GLOXY3) and 3S-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2 to yield pneumocandin B0), or 3S-hydroxyl-4S-methyl-L-proline (generated from L-leucine by the dioxygenase gloC/GLOXY4 to yield pneumocandin A0) are sequentially added to the growing chain (PubMed:25270390, PubMed:25879325, PubMed:25527531).  The last C domain of gloA/GLNRPS4 is proposed to be responsible for cyclization by condensation to form the peptide bond between L-ornithine and 3S-hydroxyl-4S-methyl-L-proline (for pneumocandin A0) or 3S-hydroxyl-L-proline (for pneumocandin B0).  Finally, the subsequent C-4 hydroxylation of 3S-hydroxyl-L-homotyrosine and L-ornithine dihydroxylation at C-4 and C-5 are performed by the cytochrome P450 monooxygenases gloP/GLP450-1 and gloO/GLP450-2, respectively (PubMed:25879325).
What are the official names of this protein?
2-oxoglutarate-dependent dioxygenase gloF, Pneumocandin biosynthesis cluster protein F, Proline hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: ASNA_SALA4
Sequence: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAEVHKQFGLAPFLPEQIQFVHSQELLSRYPDLDAKGRERAIAKELGAVFLVGIGGKLSDGHRHDVRAPDYDDWSSASELGYAGLNGDILVWNPVLEDAFELSSMGIRVDADTLMRQLALTGDEDRLQLVWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAQVRESIPAIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBX34_HUMAN
Sequence: MHLKPYWKLQKKEHPPEVSRETQRTPMNHQKAVNDETCKASHITSSVFPSASLGKASSRKPFGILSPNVLCSMSGKSPVESSLNVKTKKNAPSATIHQGEEEGPLDIWAVVKPGNTKEKIAFFASHQCSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKAKVQVERMREVNSRCYQPEPFACGIEHCSVHYVSDSGDGVYAGRPLSVIQMVAFLEQRASALLASCSKNCTNSPAIVRFSGQSRGVPAVSESYSAPGACEEPTERGNLEVGEPQSEPVRVLDMVAKLESECLKRQGQREPGSLSRNNSFRRNVGRVLLANSTQADEGKTKKGVLEAPDTQVNPVGSVSVDCGPSRADRCSPKEDQAWDGASQDCPPLPAGVSFHIDSAELEPGSQTAVKNSNRYDVEMTDELVGLPFSSHTYSQASELPTDAVDCMSRELVSLTSRNPDQRKESLCISITVSKVDKDQPSILNSCEDPVPGMLFFLPPGQHLSDYSQLNESTTKESSEASQLEDAAGGDSASEEKSGSAEPFVLPASSVESTLPVLEASSWKKQVSHDFLETRFKIQQLLEPQQYMAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPYGPGYWMCCHRSQKGFPGCKLGLHDNHWVPACHSFNRAIHKKAKGTEAEEEY
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
What are the official names of this protein?
F-box only protein 34.
Protein: URE2_RALPJ
Sequence: MIPGELLPQDGDLELNAGRPTVTVTVANTGDRPVQIGSHYHFYEVNDALRFDREAARGFRLNIAAGTAVRFEPGQERTVELVALAGDRVVYGFAGRVMGKL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNR25_MOUSE
Sequence: MVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYVQLKQEREGGVQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK
What are the official names of this protein?
U11/U12 small nuclear ribonucleoprotein 25 kDa protein, U11/U12 snRNP 25 kDa protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: PROB_YERE8
Sequence: MSGSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQQHAKGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHIGQMLLTRADLEDRERFLNARDTMNALLDNRIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQAGLYTADPRNNPQAELIREVHGIDDALRGIAGDSVSGLGTGGMATKLQAADVACRAGIDVVIAAGSQVGVIADVIEGTPVGTRFHALETPLENRKRWIFGAPPAGEITVDDGAVTAIMERGSSLLPKGIRSVVGNFSRGEVIRIRNLSGRDLAHGVSRYNSDALRMLAGHHSQQISEILGYEYGPVAVHRDDMIVS
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_PSEA6
Sequence: MHTKAVYPGTFDPITNGHADLIERAANMFAHVIVGIAANPSKKPLFSLQERVDLIKEVTEHLPNVEVIGFEGLLADFADSQGATVLIRGLRAVSDFEYEFQLANMNRRLNPNLESIFLTPAEENSFISSTLVKEVALHRGKVDQFCHPAVQAALKEKLQQ
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4B_PSYIN
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIESKCKIDNAPGVHGARKPRLSDYGLQLREKQKVRRMYGVLEKQFRNYYKESARLQGNTGENLLQLLEGRLDNVVYRMGFGATRAESRQLVSHKAVLVNGKVVNIPSFNVKASDVIAIREKAKKQSRIGAALEIAGQREVPTWVSVDATKMEGIFTRQPERSDLSAEINEQLIIELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4 B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.