PharMolix/UniProtQA huggingface dataset:
Protein: DTD_RHOJR
Sequence: MRALVQRVTSASVRVDGDEVGRITPPAGGHGLLVLVGVTHTDDEAKAALLAKKVWTMRILENEQSASDLDAPVLVASQFTLMADTRRGRRPSWSAAAPRPVAEPLVDEFTGALRELGATVETGVFGEHMEISLVNDGPVTLLIDV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_STRM5
Sequence: MDENKKRALAAALGQIEKQFGKGSVMRMGDRVVEPVEAIPTGSLMLDIALGIGGLPKGRVVEIYGPESSGKTTLTLQAIAECQKLGGTAAFIDAEHALDPIYAAKLGVNVDDLLLSQPDTGEQALEIADMLVRSGSVDILVVDSVAALTPKAEIEGEMGDQLPGLQARLMSQALRKLTGNIKRSNTLVVFINQLRMKIGVMMPGQSPEVTTGGNALKFYASVRLDIRRIGAIKKGDEIIGNQTKIKVVKNKLAPPFKQVITEILYGEGISREGELIDMGVDAKLVEKAGAWYSYGEERIGQGKDNARGYLRDNPTVAAKLEAELREKFQPSEAAREEGDDEGDDE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAP_HRSV1
Sequence: MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDNIDTPNYDVQKHLNKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILKDAGYHVKANGVDITTYRQDINGKEMKFEVLTLSSLTSEIQVNIEIESRKSYKKLLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEIKRYKGLIPKDIANSFYEVFEKHPHLIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGSGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPNFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKEDDVEL
What is the function of this protein?
Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases.  RNA replication depends on the availability of soluble nucleoprotein.  The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.  Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway.  May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs.
What are the official names of this protein?
Nucleoprotein, Protein N, Nucleocapsid protein.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses nucleocapsid family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Localizes in cytoplasmic inclusion bodies.
Protein: LRRF2_MOUSE
Sequence: MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQREGVEDTLSLRSLGSHRLDEKSDKQYAENYTRPSSRNSASATTPLSGQSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKLAGEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTAQDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ
What is the function of this protein?
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.  Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity).
What are the official names of this protein?
Leucine-rich repeat flightless-interacting protein 2, LRR FLII-interacting protein 2.
What is the protein family that this protein belongs to?
Belongs to the LRRFIP family.
Protein: EX7S_RICAH
Sequence: MTNTKTLEENISFESALKELEEIVKKIDNGQESLEMAVNSFERGILLKNHCEKKLKEARLKIEKITKLADSTVVLEETEV
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIM9_PICST
Sequence: MLSRVVRQRSRSAISSFKLRAHAAFAETRIGVGISVQATRLQSTKLSANPEEIYTKISDSADPKRNQFFQYTWGSWLENDKLKKSHRETRFSIEGVSNLVQELNLTRKDPANVDSSGEPLLQIKPVQQLKDGSFVLTNNLSNKLIGEAQDKDAKLLVKSIASIHEGKDLVLRIPYKLESDYSISQKIKSEVATLDFLSLKLGLNVPKVVAYGDNRSNALQTPFILMEYIEGDLLMKKWNPLAADSEETDASLKSVIQPISDFQDKILSVNFNKFGSLYFHDDVSVLDQADVPYDGEENPLLVNRWRIGPSIERQFAKNKNHLSEKIVKEFNGPWKADAPLSLITSVASIELENAKNRLGLAQADSASKVEDVEVLKKQIETFEHLQAIGSKLFNSKSKSIMNVEELFRPKLFVPDLDPLNVIESNDKSYFIDFEYSTIKPFILTSYPNFVAYHGAKVYNLEEDIPGFTEMDEVEKQQYEFMYYKTRNERLWELELNSRRHDLIAVASPHVKVLKSPYLQALELKTDKDYLYVEGAIVQLQAMWDAYVANELCGSSSSEFPVQYTEEFLDRHQTDLEEYQIETVSSPFAATGGWIPQDMFETLKEQGIIVETENGNYKVEAEKALEEEPEEK
What are the official names of this protein?
Altered inheritance of mitochondria protein 9, mitochondrial, Found in mitochondrial proteome protein 29.
What is the protein family that this protein belongs to?
Belongs to the AIM9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RN185_MOUSE
Sequence: MASKGPSASASTENSNAGGPSGSSNGTGESGGQDSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA
What is the function of this protein?
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (By similarity).  Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (By similarity).  Protects cells from ER stress-induced apoptosis (By similarity).  Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (By similarity).  Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity (PubMed:28273161).  Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF185, RING finger protein 185.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YQGF_RUBXD
Sequence: MSPPEGRVAALDLGEVWTGVAVSDPTRTLARPLEVVRTSELPGVLRRLVREEGVGEVLVGLPRTLRGEVGFQARRVSDRLSSLRAGFPEVRFVEWDERLTTKVVSGPLREGRRRGRRERVDHLAAARMLQEYLELGGGA
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_STRGC
Sequence: MVKNLLVELGLEEMPAYVVTPSMKQLRDKMGAFLTDHRLTFEKIEMFSTPRRLAVRVVGLADKQSDLTEDFKGPSKKIALDADGNFTKAAEGFVRGKGLTVEDITFREIKGEEYVYVTKEEIGRPVEEIIPAVTEVLQALTFPVSMHWANNTFEYIRPVHTLTVLLDEQAFDLDFLDIKSGRTSRGHRFLGQETEIASADSYEDDLRAQFVIASPLERGDMIVDQIQALEEEHGVSIEIDEDLLNEVLNLVEYPTAFLGNFDAKYLEVPEEVLVTSMKEHQRYFVVRDSEGKLLPHFISVRNGNAEHLENVIKGNEKVLVARLEDGEFFWREDQKLAIADLVEKLNNVTFHEKIGSLAEHMERTGKIAALLAQEAGLDADETADLARAAAIYKFDLLTGMVGEFDELQGIMGEKYALLAGENAAVAAAIREHYMPTSADGELPDTKVGAVLALADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDKFGWNIDLAQLLGRLYELKFDSLSYDNQEAVLDFFRARVEKMMDRSIPKDIVTAVLQSTHFVVRDLVETAALLAEKAQEDNFKSAVESLSRVFNLAEKAQGQTAVNPALFENKEEKDLAAAIEKVVLTSDLAANLDQFFALSPVIDAFFDHTMVMAEDEAVRNNRLALLASLTAKAGQIAQFNQINTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_DESVV
Sequence: MSQFDVTVFTDGSCLGNPGPGGWAAIMRCNGCEKELSGGFALTTNNRMEILAVLEALEALRDPCKVTLFTDSQYVRNAVEKKWLAGWQRNGWKTADKKPVKNRDLWERLVPLLAKHSVSFRWVRGHSGHPENERCDVLARAQASRRGLPEDPGFTA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_THEYD
Sequence: MIQPRSILEVADNSGAKRVQCIRVLGGSNRKYASLGDVIIVSVKEALPDSNIKKGSVAKAVIVRLRRSVRRNDGSYIRFDQNAVVLVNNQLEPIGTRIFGPVARELRWKEFTKIVSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: TRPF_BACC1
Sequence: MKVKICGITDMETAKRACEYGADALGFVFAESKRKITPGLAKEIIQELPANVLKIGVFVNESVEMIQKIADECGLTHVQLHGDEDNYQIRRLNIPSIKSLGVTSESDMKNAQEYETDYILFDSPKEKFHGGNGKTFSWELLAHMPKELREKTILAGGLNALNIEEAIRTVRPYMVDVSSGVETEGKKDVEKIKQFIIKTKECSK
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: DXR_ACTPJ
Sequence: MKKLVILGSTGSIGKSTLSVVEQNKTEYEVFGLVGGKNVELMAAQCLLFQPKFAALDDENAAKALEEQLRQLNVKTEVLSGQKAICELSAHPEVDMVMAAIVGAAGLLPTLSAVKAGKKVLLANKESLVTCGQIFIDEARKSGAQLLPVDSEHNAIFQSLPPEAQQKVGFCPLAELGVSKIILTGSGGPFRVKPLDEFAAITPAQAVAHPNWSMGKKISVDSATMMNKGLEYIEARWLFNASAEEMEIIIHPQSIIHSMVRYIDGSVIAQMGNPDMCTPIAHTMAYPKRINAGVAPLDFFKLKELTFIEPDFARYPNLKLAIDAFAEGQYATTAMNAANEVAVEAFLNERIRFIDIVNVNRTVVENIAPVQVKEIADVLHIDKLARELAEQAVINL
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: NADK_MYCPN
Sequence: MKYKIFASTTPQTEPVLQKLKQVLKGCEAVEKGFDYLFVLGGDGFFVSTVANYNCHNCRVVGINTGHLGFYTSFNEKDLDDNFLQKLQQCHFQRISLLEVSVNGQQHLVLNELAVYTNTAYPINIFIDGEAWEFYRGSGLLIGPRTGSTALAKSAKGAVIFPGIDVLQIIEMNPLLHPNQVTIQSPIILPKETQVEFVVKKAFNPQQFPTFYCDGRKLELPNADTTLALKLVQSTPMFNISLKTQDFINKLKSTFIKQS
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGF7_MOUSE
Sequence: MRKWILTRILPTLLYRSCFHLVCLVGTISLACNDMSPEQTATSVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNSYNIMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGIPVKGKKTKKEQKTAHFLPMAIT
What is the function of this protein?
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation.  Required for normal branching morphogenesis.  Growth factor active on keratinocytes.  Possible major paracrine effector of normal epithelial cell proliferation (By similarity).
What are the official names of this protein?
Fibroblast growth factor 7, FGF-7, Heparin-binding growth factor 7, HBGF-7, Keratinocyte growth factor, KGF.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted.
Protein: PHAE_RHIME
Sequence: MRTWFPYPLLSIALLLMWLLLSQSVTPGSIVLGLVVSTVLAWVTLNLQPARSRLHRWSRIAGFILRVVGDVIRSNIAVTLIILRAGRRPVNAGFMTVSLDLDDENALALLACVVTATPGTAWLEYDRRQKILLFHVLDIENEDLWRKTITRYAADLKEIFE
What is the function of this protein?
Part of a K(+) efflux system which is required for the adaptation of R. meliloti to alkaline pH as well as for the infection process during symbiotic nodule development.
What are the official names of this protein?
Probable K(+)/H(+) antiporter subunit E, pH adaptation potassium efflux system protein E, Pha system subunit E.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UL110_HCMVA
Sequence: PLKTKPIDNNLPHRTGYNQASKQQTAPPCLLQRTVTTYVCRLPSRSGFWGSPPLPIIFSFVPDGRLSVRALVFSSMCAGFVIGEEDRDRIIMMIIIIHSPTIFILFCCSKEKRKKKQAATLTITLTS
What are the official names of this protein?
Uncharacterized protein UL110.
Protein: SYL_XANOP
Sequence: MSTVEPNVYDPHQVETSAQQFWDATRAFQVDENSEKPKFYCLSMLPYPSGALHMGHVRNYTISDVVSRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAKWTYANIAHMRAQLKSLGYAIDWSREFATCTPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPIDQTVLANEQVIDGRGWRSGAVVEKREIPQWFLRITDYAQELLDGLDQLDGWPDSVKTMQRNWIGRSEGLEIQFDVRDTNGAALDPLRVFTTRPDTLMGVTFVSIAAEHPLALHAAKSNPELAALLETLKHGGVSEAELETQEKRGMAIGLTAVHPISGEQVPVWVANFVLMGYGTGAVMAVPGHDQRDFEFANKYGLPIVQVVKLREPRNDDEQRWDATEWRDWYTDKSRELELINSAEFDGLDFGGAFEALAERFERKGQGQRRVNYRLRDWGVSRQRYWGCPIPVIYCPKCGAVPVPEDQLPVVLPENVEFAGTGSPIKTEPTWRQTTCPDCGGPAERETDTFDTFMESSWYVARYTSPNAREMVDRRANYWMPADLYVGGIEHAILHLMYFRFYHKLMRDARLVDSDEPVTNLLTQGMVIADTFYRDADNGGKDWINPADVEIQRDERGRVTGAVLIADGQPVHIGGTEKMSKSKNNGVDPQSMVAKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARFMRRLWAQVHKHVGEGAAVALDVAALSAEQKAIRRKTHETIGKVSDDYGRRHSFNTAIAAVMELSNALAKFDDASDQGRAVRQEALEAMVLLLNPITPHASHALWQVLGRGETLLENVAFPQADVSALVRDALTLAVQINGKLRGTIDVAADAAREQIEALAQAEPNAAKFLDGLSVRKIIIVPGKIVNIVAG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT_ASPOR
Sequence: MDDETAAIVIDNGSGMCKAGFAGDDAPRAVFPSLIGRPRHHGIIVGMGQKDSYVGDEAQSKRGVLSLHYPIEHGIVNNWDDMEKIWHHTYFNELRVASEEHPVLLTEAPINPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFSMPHAIARMDLAGRDLTEYLVRILAERGHSFTTSAEHEIVRDIKERLCYVALDFEQELETAAKSSSIEKSYELPDGQVIAIGNERFRAPEALFQPSLLGIEQGGIHETTFNSIQKCDVDVRKDLYGNIVMSGGTTLYPGIADRLHKELVNLSPSSMKIKTIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SMRCD_MOUSE
Sequence: MNLFNLDRFRFEKRSKIEEAPEAAPQPSQARPSSPISLSAEEENAEGEGSRANTPDSDVTEKTEDSSVPEPPDNERKASLSCFQNQRAIQEYIDLSSDTEDVSPNCSSTVQEKKFSKDTVIIVSEPSEDEESHDLPSVTRRNDSSELEDLSELEDLKDAKLQTLKELFPQRSDSDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEEDDVNDDQSVKQPRGDRGEESNESAEASSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQDVQCASQSEVTNGKEVARNQNYSKNATKIKMKQKISVKPQNGFNKKRKKNVFNPKKAVEDSEYDSGSDAGSSLDEDYSSCEEVMEDGYKGKILHFLQVSSIAELTLIPKCSQKKAQKITELRPFNNWEALFTKMSKINGLSEDLIWNCKTVIQERDVVIRLMNKCEDISNKLTKQVTMLTGNGGGWNREQPSLLNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLCYYGSQEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKPADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKLLPPKKDRIELCAMSEKQEQLYSGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQYYTPEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYQHINSYQLDMDLILDSGKFRALGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEADEGSMPADIATLLKTSMGL
What is the function of this protein?
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization.  Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs.  Required for the restoration of heterochromatin organization after replication.  Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity).
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1, ATP-dependent helicase SMARCAD1, Enhancer trap locus homolog 1, Etl-1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage (By similarity).
Protein: OMT1_ARATH
Sequence: MGSTAETQLTPVQVTDDEAALFAMQLASASVLPMALKSALELDLLEIMAKNGSPMSPTEIASKLPTKNPEAPVMLDRILRLLTSYSVLTCSNRKLSGDGVERIYGLGPVCKYLTKNEDGVSIAALCLMNQDKVLMESWYHLKDAILDGGIPFNKAYGMSAFEYHGTDPRFNKVFNNGMSNHSTITMKKILETYKGFEGLTSLVDVGGGIGATLKMIVSKYPNLKGINFDLPHVIEDAPSHPGIEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCVKFLKNCYESLPEDGKVILAECILPETPDSSLSTKQVVHVDCIMLAHNPGGKERTEKEFEALAKASGFKGIKVVCDAFGVNLIELLKKL
What is the function of this protein?
Methylates OH residues of flavonoid compounds.  Converts quercetin into isorhamnetin.  Dihydroquercetin is not a substrate.  Catalyzes the methylation of monolignols, the lignin precursors.  Does not contribute to the phenylpropanoid pattern of the pollen tryphine, but is probably confined to isorhamnetin glycoside biosynthesis (PubMed:10700397, PubMed:12777055, PubMed:20652169, PubMed:22258746).  Involved in melatonin biosynthesis (PubMed:25039887, PubMed:25250906, PubMed:32354877).  Functions as an acetylserotonin O-methyltransferase that catalyzes the transfer of a methyl group onto N-acetylserotonin (NAS), producing melatonin (N-acetyl-5-methoxytryptamine) (PubMed:25039887, PubMed:25250906).  Can also methylate serotonin into 5-methoxytryptamine (5-MT) with low catalytic activity (PubMed:25250906).  Implicated in melatonin-dependent circadian dynamics of stomatal aperture to minimize night water loss and promote drought tolerance (PubMed:32064655).  Prevents the accumulation of oil and anthocyanin content in mature seeds, as well as mucilage production in the seed coat, in a melatonin-dependent manner (PubMed:32354877).
What are the official names of this protein?
Flavone 3'-O-methyltransferase 1, AtOMT1, Acetylserotonin O-methyltransferase OMT1, Caffeate O-methyltransferase 1, AtCOMT, Quercetin 3'-O-methyltransferase 1, Serotonin O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: LPXB_COXBN
Sequence: MSNKSVLLIAGEPSGDLLGAHLAQSLKSLEPNLKLAGMGGKRMREAGVEVFINADKLAVVGLLEILRQFRDIRHAMQTLKRYFKKTPPDLVVFIDYPGFNLHMAKQAKKAGIKVLYYVSPQIWAWRYGRIKKIKKYVDHMAVLFDFEEKLYQKENVPVSFVGHPLANAPTPSLSRNEICKQFNLDPDKPIVALFPGSREQEINKLLPMMVQAGKLIQTQIPTVQFILPLALNLALDKIRPFLSPEIKVIQNDISHVLAIAHAAVAASGTVTLEIALQQVPLVIIYKVAPLTFWLGKKLIRLSFIGLCNLVSPEPVAVELLQQDATPQAIADEVFQLLNNHNYRQSIIGKLGHLRPQLDRGNAAQNVAKVVHNLIFS
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: RPPH_CUPTR
Sequence: MLDREGFRPNVGIILLNARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEIGLLPEHVRIVGRTRDWLRYEVPDKFIRREIRGHYKGQKQIWFLLRMAGRDCDIHLRATEHPEFDAWRWSHYWVPLEAVIEFKRDVYQMALTELSRFLNRHPRVPLSPYGTHGAHGAHGVHGRHGGPRGQALSRAQAAQQADADGNAEVPGAADYVSPATPVSTTRSTDD
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: MPV17_HUMAN
Sequence: MALWRAYQRALAAHPWKVQVLTAGSLMGLGDIISQQLVERRGLQEHQRGRTLTMVSLGCGFVGPVVGGWYKVLDRFIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGALNGLSAQDNWAKLQRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL
What is the function of this protein?
Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:25861990).  Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297).  May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity).
What are the official names of this protein?
Protein Mpv17.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal membrane protein PXMP2/4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: THII_BACC3
Sequence: MMTYEYILVRYGEMTTKGKNRSKFVSTLKDNVKFKLKKFPNIKIDATHDRMYIQLNGEDHEAVSERLKDVFGIHKFNLAMKVPSELEDIKKGALAAFLQVKGDVKTFKITVHRSYKHFPMRTMELLPEIGGHILENTEDITVDVHNPDVNVRVEIRSGYSYIMCDERMGAGGLPVGVGGKVMVLLSGGIDSPVAAYLTMKRGVSVEAVHFHSPPFTSERAKQKVIDLAQELTKYCKRVTLHLVPFTEVQKTINKEIPSSYSMTVMRRMMMRITERIAEERNALAITTGESLGQVASQTLDSMHTINEVTNYPVIRPLITMDKLEIIKIAEEIGTYDISIRPYEDCCTVFTPASPATKPKREKANRFEAKYDFTPLIDEAVANKETMVLQTVEVVAEEEKFEELF
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.