PharMolix/UniProtQA huggingface dataset:
Protein: RL4_WOLSU
Sequence: MSKAIILNNELQKNGEVALPERFKEIHSHNLYLYVKSYLASLRANSAKAKKRGEVSGGGKKPWSQKGGGRARAGSITSPVFVGGGVSHGPSNNRNYDLKVNKKQKKLALQYALMEKAEQGKLYVVDSLQVDSGKTKDAYAMFKTLNERSTLFVSQISDEKTFLAFRNLKECYLADANELNAYLVAAFRSVVIEKSLFENITKEG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: YCGJ_BACSU
Sequence: MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDIGAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDDSFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLRDPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLNHASDEARDTFCITLNQNGQPISFCLKAILIQGIKR
What are the official names of this protein?
Uncharacterized methyltransferase YcgJ.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: BIOH_SALA4
Sequence: MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLVDLPGYGRSSGFGAMTLEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGIKPEILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLKSVVLAQPMPDVEVLNGGLEILKTVDLREALKNVNMPFLRLYGYLDGLVPRKMVPLLDTLWPHSTSQIMAKAAHAPFISHPAAFCQALMTLKSSL
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLB_SALTI
Sequence: MTLPDFRLIRLLPLASLVLTACTLPGHKGPGKSPDSPQWRQHQQEVRHLNQYQTRGAFAYISDDQKVYARFFWQQTGQDRYRLLLTNPLGSTELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLTGMPIPLNSLRQWILGLPGDATDYKLDDQYRLSEVNYHQDGKNWKVVYGGYDSKTQPAMPANMELSDGSQRIKLKMDNWIVK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: F16A2_CERS1
Sequence: MAIELEDLGLSPDVADVMQRLARVGAGIARIISRNGLERDLGAGVGTNAGGDGQKALDVIADDAFRAALEGSAVAYYASEEQDEVVTLGEGSLALAIDPLDGSSNIDVNVSIGTIFSIFPAAAGPEASFLRPGTEQIAGGYIIYGPQCALVCSFGQGVQHWVLDLDAGIFRRMPDIRPLPAETSEFAINASNYRHWPQPIRAFVDDLVAGAEGPRGKNFNMRWIASLVAETHRILMRGGVFLYPGDERKGYERGRLRHVYECAPIAFLIANVGGRATDGCADILTALPDRLHARTPFVFGCASKVARVAAYHDLACEETSALFGSRGLFRS
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 2, FBPase class 1 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRC6_CANAL
Sequence: MIPNHILILGSPNSGKLRIANLISKNEEIPNLEDVESHSGLIVKTSLRTKYYFLKLNILIDEYSESKEATDEKKLSELHKWYQEFKSEEFGELREVLDGLMFTINMKTDSISFIGDALEIIEQIKISLGDEENLHDWGGFIAVVGSCPENQIVEDDLILEIEDMVLSQGLEFINLSTEGENEYKEKQGKDRIVELIESHDWTNLEMLKVDSKQYETNKLAKMESMKQKLINEKEELDLDDIFSKLNLARDHAQSLTQDERDKYANKVIEEIIDFL
What is the function of this protein?
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
What are the official names of this protein?
Increased recombination centers protein 6.
What is the protein family that this protein belongs to?
Belongs to the IRC6 family.
Protein: LEUC_OCEIH
Sequence: MQKPQTIFEKIWENHMVHEEEGKPSLLYIDQHLVHEVTSPQAFEGLRLNNRKVRRPDLTFATMDHNVPTVNRESFKDEISKKQMDALKKNCEEFGIKLADMYHPDQGIVHVIGPQLGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTIWQDKPKTLNVKVIGELGIGVTAKDLILAIIAKFGVQFGTGYVMEYTGESIRKMSMEERMTICNMSIEAGARAGLISPDQTTVDYLRGREMVPKGEAYDTLAAEWLQLATDEDAVYDDTVTIHANEIEPQVTWGTNPGMCVPISSSTPSIEKASYPDEVERALEYMGLTENQLMTSIEVDHVFIGSCTNSRLSDLKKAAAIVKGKKVKAGIRAMVVPGSFLVKQKAEEIGLDQVFMDAGFEWRNSGCSMCLGMNDDIVPAGGRCASTSNRNFEGRQGNGARTHLVSPEMAAAAAIEGHFVDVRSYASVPS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RPOA_RHIE6
Sequence: MIQKNWQELIKPNKVEFSSSSRTRATLVAEPLERGFGLTLGNALRRVLLSSLRGAAVTAVQIDGVLHEFSSIPGVREDVTDIVLNIKEIAIKMDGDDAKRMVVRKQGPGVVTAGDIQTVGDIEILNPEHVICTLDEGAEIRMEFTVNNGKGYVPAERNRAEDAPIGLIPVDSLYSPVKKVSYKVENTREGQVLDYDKLNMTIETDGSITGEDAVAFAARILQDQLGVFVNFDEPQKETEEEAVTELAFNPALLKKVDELELSVRSANCLKNDNIVYIGDLIQKTEAEMLRTPNFGRKSLNEIKEVLASMGLHLGMEVPAWPPENIEDLAKRYEDQY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: NODI_RHILT
Sequence: IYGGDPQELSLLIKPYARRIEISGETLFCYTPDPEQVRAQLRGHRGLRLLERPPNLEDVFLRLTGREMGKYQ
What is the function of this protein?
Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction.  Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide.  This subunit is responsible for energy coupling to the transport system.
What are the official names of this protein?
Nod factor export ATP-binding protein I, Nodulation ATP-binding protein I.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipooligosaccharide exporter (TC 3.A.1.102) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VP15_BPAPS
Sequence: MCSDITGGAQSSSNVAGMGAGGTGRYFIGVRTQPVNSGSRHRQMSAAFGGNRFLYLNRLRLGCLYGLLVCILRGSRYGVKNINRLLIVGKLCTGSVAFGTQ
What are the official names of this protein?
Putative protein p15.
Protein: GANA_THETO
Sequence: ALTYRGVDWSSVVVEERAGVSYKNTNGNAQPLENILAANGVNTVRQRVWVNPADGNYNLDYNIAIAKRAKAAGLGVYIDFHYSDTWADPAHQTMPAGWPSDIDNLSWKLYNYTLDAANKLQNAGIQPTIVSIGNEIRAGLLWPTGRTENWANIARLLHSAAWGIKDSSLSPKPKIMIHLDNGWDWGTQNWWYTNVLKQGTLELSDFDMMGVSFYPFYSSSATLSALKSSLDNMAKTWNKEIAVVETNWPISCPNPRYSFPSDVKNIPFSPEGQTTFITNVANIVSSVSRGVGLFYWEPAWIHNANLGSSCADNTMFSQSGQALSSLSVFQRI
What are the official names of this protein?
Arabinogalactan endo-beta-1,4-galactanase, Endo-1,4-beta-galactanase, Galactanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 53 family.
Protein: NMDE4_RAT
Sequence: MRGAGGPRGPRGPAKMLLLLALACASPFPEEVPGPGAVGGGTGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQLAGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRTQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAARPPPGPAPFVPRERAAADRWRRAKGTGPPGGAAIADGFHRYYGPIEPQGLGLGEARAAPRGAAGRPLSPPTTQPPQKPPPSYFAIVREQEPTEPPAGAFPGFPSPPAPPAAAAAAVGPPLCRLAFEDESPPAPSRWPRSDPESQPLLGGGAGGPSAGAPTAPPPRRAAPPPCAYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRGGPAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPPPRRRARCGCPRPHPHRPRASHRAPAAAPHHHRHRRAAGGWDFPPPAPTSRSLEDLSSCPRAAPTRRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV
What is the function of this protein?
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.  Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7512349, PubMed:21522138, PubMed:23625947).  Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:7512349, PubMed:23625947).
What are the official names of this protein?
Glutamate receptor ionotropic, NMDA 2D, GluN2D, Glutamate [NMDA] receptor subunit epsilon-4, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: NQOR3_RHIME
Sequence: MTKMLVLYYSSYGHIEAMAKAVANGAKQAGATVALKRVPELVPEAVARSSGYRLGQEAPIATVAELADYDAIVIGTPTRFGNMASQMKNFLDQTGGLWAENKLVGKVGSVFTSTGSQHGGQESTILSTHVVMLHLGMVIVGLPYSFKGQMRMDEITGGSPYGASTLAEDENHRDRSPSANELDGARFQGRHVAEVAAAMQLGRSHLQPELVR
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone) 3, Flavoprotein WrbA 3, NAD(P)H:quinone oxidoreductase 3, NQO 3.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: LUXA_VIBHA
Sequence: MKFGNFLLTYQPPELSQTEVMKRLVNLGKASEGCGFDTVWLLEHHFTEFGLLGNPYVAAAHLLGATETLNVGTAAIVLPTAHPVRQAEDVNLLDQMSKGRFRFGICRGLYDKDFRVFGTDMDNSRALMDCWYDLMKEGFNEGYIAADNEHIKFPKIQLNPSAYTQGGAPVYVVAESASTTEWAAERGLPMILSWIINTHEKKAQLDLYNEVATEHGYDVTKIDHCLSYITSVDHDSNRAKDICRNFLGHWYDSYVNATKIFDDSDQTKGYDFNKGQWRDFVLKGHKDTNRRIDYSYEINPVGTPEECIAIIQQDIDATGIDNICCGFEANGSEEEIIASMKLFQSDVMPYLKEKQ
What is the function of this protein?
Light-emitting reaction in luminous bacteria.
What are the official names of this protein?
Alkanal monooxygenase alpha chain, Bacterial luciferase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the bacterial luciferase oxidoreductase family.
Protein: GVPJ_NOSS1
Sequence: MTTTPIHPTRPQTNSNRVIPTSTQGSTLADILERVLDKGIVIAGDISISIASTELIHIRIRLLISSVDKAREMGINWWENDPYLSSKSQRLVEENQQLQQRLESLETQLRLLTSAAKEETTLTANNPEDLQPMYEVNSQEGDNSQLEA
What is the function of this protein?
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms.  They allow the positioning of the organism at the favorable depth for growth.  This protein could be important for the shape determination of the gas vesicle.
What are the official names of this protein?
Gas vesicle protein GvpJ.
What is the protein family that this protein belongs to?
Belongs to the gas vesicle protein type A family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: KHSE_CORA7
Sequence: MSIDIEVGTKVTVQVPASSANLGPGYDTLGIALSLYDTVEVEVTRSGLEVEIFGEGAEELPRDGSHLVVKAIRSALKAADVEVTGLRVVCTNNIPQSRGLGSSASAAVAGVAAGNGLAGFPLSEEQVVQLSSAFEGHPDNAAASVLGNAVVSWTTVPVDGRSLPEYRAATLEVHPSIKATALVPDFHASTQAVRRVLPSHVTHADAAFNVSRTAVNVAALTAYPDLLWEGTRDRLHQPYRADVLPVTAEWVNRLRNRGYAAYLSGAGPTVMVLHTEPIEEAILDDAREQNLRVLELEVAGPVSVERG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_HELHP
Sequence: MGLKSDTWIKKMSKKGMIEPFCEKQVGKNIVSYGLSSYGYDIRVGNEFMIFTNIGANLVDPKSFDERNVVEITTEENGYCLVPPNSFALARTIEYFRIPRNVLAICLGKSTYARCGIIVNVTPFEPEFEGHITIEISNTTPLPAKIYANEGIAQVLFLEGDETCEVSYKDKKGKYQGQKGITLPKVIK
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: HV02_HETFR
Sequence: LGSTTMNWVRQGPGXGLEWLVSYYGPSKNAYAPEIKDRFTASKDTSNNIFALDMKSLKTEDTAIYYCVGQRNYYYFDFWGQGTMVTVTA
What are the official names of this protein?
Ig heavy chain V region HC-3.
Protein: HSP1_TRAGE
Sequence: MARYRCCRSQSRSRCCRPRRRCRRRRRRSCRARRRATRCCRRRYRLRCRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: OR2A5_HUMAN
Sequence: MTKNQTWVTEFILLGFPLSLRIQMLLSGLFSLLYVFTLLGNGAILGLIWLDSRLHTPMYFFLSHLAIIDISYASNNVPKMLTNLGLNKRKTISFVPCTMQTFLYMAFAHTECLILVMMSYDRYMAICHPLQYSVIMRWGVCTVLAVTSWACGSLLALVHVVLILRLPFCGPHEINHFFCEILSVLKLACADTWLNQVVIFAASVFILVGPLCLVLVSYSRILAAILRIQSGEGRRKAFSTCSSHLCMVGLFFGSAIVMYMAPKSRHPEEQQKVLSLFYSLFNPMLNPLIYSLRNAEVKGALKRVLWKQRSK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2A5, Olfactory receptor 2A26, Olfactory receptor 2A8, Olfactory receptor 7-138/7-141, OR7-138, OR7-141.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APT_PSEAB
Sequence: MIFDEFTLKSQIRAVPDFPKPGVVFRDITPLFQSPRALRMTVDSFVQRYIEADFSHIGAMDARGFLIGSAVAYALNKPLVLFRKQGKLPADVLAEGYQTEYGEAFLEVHADSLCEGDSVLIFDDLIATGGTLLAAASLVRRLGARVFEAAAIIDLPELGGSTRLQDAGISTFSLTAFALDER
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_ARCFU
Sequence: MIVSILGAGAMGSALSVPLVDNGNEVRIWGTEFDTEILKSISAGREHPRLGVKLNGVEIFWPEQLEKCLENAEVVLLGVSTDGVLPVMSRILPYLKDQYIVLISKGLIDFDNSVLTVPEAVWRLKHDLRERTVAITGPAIAREVAKRMPTTVVFSSPSESSANKMKEIFETEYFGVEVTTDIIGTEITSALKNVYSIAIAWIRGYESRKNVEMSNAKGVIATRAINEMAELIEILGGDRETAFGLSGFGDLIATFRGGRNGMLGELLGKGLSIDEAMEELERRGVGVVEGYKTAEKAYRLSSKINADTKLLDSIYRVLYEGLKVEEVLFELATFK
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPE51_MYCTU
Sequence: MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAELATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTAIQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATEAQYAEMWAQDAAAMYGYATASAAAALLTPFSPPRQTTNPAGLTAQAAAVSQATDPLSLLIETVTQALQALTIPSFIPEDFTFLDAIFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEVTPGDFGIGELVSATSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSALSPAGLTTLPGTDVAEHGMPGVPGVPVAAGRASGVLPRYGVRLTVMAHPPAAG
What is the function of this protein?
Plays a role in response to starvation and stress, likely environment within the host.  Inhibits canonical autophagy in infected mouse RAW264. 7 macrophages.  Inhibits autophagy and enhances intracellular bacterial survival when expressed in human macrophage-like THP-1 cells.  Inhibits Toll-like receptor 2 (TLR2)-dependent signaling leading to autophagy inhibition, increased intracellular bacterial survival, reduced phagocytosis and reduced secretion of interleukin 6 (IL-6) and IL-1 in infected mouse primary bone marrow-derived macrophage (BMDM) cells.  Required for virulence and persistence in the lungs and spleens of intranasally infected C57BL/6J mice.  Blocks the antibacterial effects of TLR2 activation, suppresses MHC class II-dependent antigen presentation, and reduces IFN-gamma and TNF-alpha-producing CD4(+) T cells during infection in C57BL/6J mice.
What are the official names of this protein?
Transporter PPE51, Proline-proline-glutamate family protein 51, PPE family protein 51, Protein PPE51.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: Y587_PSYIN
Sequence: MEALKIFGIFTVTAVAEIVGCYLPYLWLRQGHSIWLLVPAAFSLAAFVWLLTLHPEAAGRTYAAYGGIYVSVALMWLWLVESTRPTMTDLLGVLICIIGMAVIMFGPRNV
What are the official names of this protein?
UPF0060 membrane protein Ping_0587.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PLK4_DROSI
Sequence: MLSNRAFGETIEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTSRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRSSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGVHSAPGALNVFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQVLPQIREEFKQVHHKLPYEQPGLFGQASTGLAEPNWPGAAKTSAFRMETGMVPNSKPASLKEDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPPDLQIPSGDCVYNYDNLPNKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMETMTDFEIRFYSGAKLLKTPSEGLKVYDRNGMLLSDHSCSESRSLIEHGNECFTHCVNISNALEVAQTKDNSCFPVTIGRRPITDVQPAQRLDGLRDTTNIAFSTPKSNQGSINFSLSTISSTRNTSDFGTNCSRSNMLAAHQNIPIKRINVPDIGIATELSHGVVQVQFYDGSVVSVIPSMQGGGITYTQPNGTSTHFGKDDDLPFPVRDRVGQIPNIQLKLKTAPLLGSGRKTDYNNAMTPKTTTPYYNRMLL
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase SAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: TATC_DESAH
Sequence: MSREEEKSPFTEHLGELRDRLVRSFIAVGVGFVIAYCFKERLFDILTAPLIAAMGEGQKMIFTGLPEAFFTYLKVSLLTGVILATPVLFYEFWMFVSPGLYRKEKRFVLPVVILSIFFFCVGSSFGYFIVFPYGFQFFLGFSSDTIQAMPSMKEYLGFASKMLLAFGFVFELPLVLTFMARMGLVSVEFLKKNRKYAILIFFTGAALITPPDVVTQIMMAIPLMILYEISIIGARVFGKKKDSDEEEAAENSDVQTDKSTDDTTPGEDQN
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
What are the official names of this protein?
Sec-independent protein translocase protein TatC.
What is the protein family that this protein belongs to?
Belongs to the TatC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IHOG_DROME
Sequence: MTLLTSSLLLFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPAHPAHPAHPSPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVSQEAAISRLRVLVRPDTLGEYRCVGWFGPLVVTSTIARLELASTSLVDAQESESPLQWRVSAGNSVLWSCGQQVQSNPSASWSYYRNGVEIKPEFIGTNGNLFLSNVSSESSGSYSCQATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWSLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVLILLLISTCFCVCRRRNSRSRGNNPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHITLNPLAQQQQQALEEKNDTDQDAPYYQRPSSYDYDPTLRRMSSSSLRRSQRTLERAGGSNGSNNGNNNNLNQSAEAGSIENPGKPGRVLMKRPRLSSRSENLSSGSLNSVGV
What is the function of this protein?
Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).
What are the official names of this protein?
Interference hedgehog.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. IHOG family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MIAA2_TREDE
Sequence: MNLDFLSLSDKHNSVVVLGATATGKTSYAVGLAKELGGEIISADSRQVYKGLDLGTGKDLKEYGDVPHHLIDICTLEREYNVFDFQNDAYKAFEDIKRRKKLPIFAGGTGLYLDSLIREYELIPVPKNEELRASLAGKDLTELQKFFFEYNVPMHNKTDLENMDRLMRAIEIAEYKKTHPDAAEILNANRPDIRPLIIGLKYPREILRERIRLRLLERIKDGMIEETESLHKEGFSWERLESLGLEYKFTAQYLQGKIKSREEYVDSLYRAICQFAKRQETWFRRMEKNGVKINWVLK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase 2, Dimethylallyl diphosphate:tRNA dimethylallyltransferase 2, DMAPP:tRNA dimethylallyltransferase 2, DMATase 2, Isopentenyl-diphosphate:tRNA isopentenyltransferase 2, IPP transferase 2, IPPT 2, IPTase 2.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PUR5_ENTFA
Sequence: MENAYSKAGVNVEAGYEVVERIQKHSQKTQRTGTLGMLGGFGGCFDLSSYKLKEPVLVSGTDGVGTKLLLAIEEQKHETIGIDCVAMCVNDVVAQGAEPLYFLDYLALGTVNPAKVEAIVAGVAAGCCEANAALIGGETAEMPDMYEADAYDVAGFAVGIAEKSQLLTPSNVKEGDFLIGLPSSGLHSNGYSLVRNIFFKKHSFKTTDKLPELAPKTLGEELLTPTKIYVKELLPLLKAGLVHGAAHITGGGFLENLPRMFSSALAAEIQLNSWPVLPIFKLIQKYGEIPPEEMYEIFNMGLGMILAVSPEHVEKVQELLPEAFEIGRLVPRKTKAVIFKEAL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_ENTFA
Sequence: MVIFKTVNDVRSQVKEWKKQGLKVGLVPTMGYLHEGHESLIRKASKENDKVVVSIFVNPTQFGKNEDLGSYPRDLERDIEVCTRGRATAIFNPEVEEMYCDNASTFVNITGLTEGLCGASRPIHFRGVCTVVSKLFNIIPADRAYFGEKDAQQLAVIKRMVRDLNIDIDVVGCPIIREEDGLAKSSRNTYLSLEERSSATILNKSLTLAKEALNNGERDSLKIIEIISKNINTCNLAKIDYVEVVDSLSLQRVNYIEKSVLVAIAVFIGKTRLIDNFTFELQ
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.