PharMolix/UniProtQA huggingface dataset:
Protein: GLVR_BACSU
Sequence: MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKACSVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKDMTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFKVNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVTLSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE
What is the function of this protein?
Positive regulator of the glv operon expression, which consists of GlvA, GlvR and GlvC.
What are the official names of this protein?
HTH-type transcriptional regulator GlvR, Glv operon regulatory protein.
Protein: PRMA_CHLTE
Sequence: MQPPKTHNHIELAFEIDSDLYELYIAVLSQVGIEYFLEDDHKLLAYLPESDWNADKEASINIMLQETFGSVPRFTASFMADRNWNAEWEAHLQPVEISDRFLIIQHQKEYDVKPGQIVIAINPKMSFGTGYHATTRLMLRQMEELDLADKKIMDIGTGTGVLAIAARKLGNRNPILAFDNNAWAAENAVENVAENDVADIRVELLDAEEELAATLEEGYDLILANINKNVLDRILPTIRRHAPNAQVLLSGVLVYDEPWLKQLLKRIKYTNVKTIYEDEWLSALVEPKN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPTA_PICTO
Sequence: MIELKDVQGFRPDYEIPIKRAGIKSFKRRVKLNYNNESFDSYVDVSISVSLNPDRKGLDMSRTIESVRSSYNLNDVAYDIYNDLFSRINYSSSGYVNVSFDFYYNNKIYPVSLIAEGDKNDVKRYVEVSAEGMTVCPCAMETIRSIMLYDYNVSYGDIGISHNQRNKASLKIQYIKDAHLERLIDILESSFSYPVRNMLKRYDEGKMIIEAHKRPKFVEDVVREIAYKAAFMEPEMNLYMDVRSESFESIHPHNAYAEIEDYTANIRSYLKNR
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: GLYA_STRZT
Sequence: MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVMAAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQANCAAYMSLIEPGDTVMGMDLASGGHLTHGAPVSFSGQTYNFVSYSVDPETELLDFDAILKQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPVPYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVSFKEVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQNLLDEVNITLNKNSIPYETLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKNSENEAVLEEVRSAVKELTDAFPLYED
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG2_BORPA
Sequence: MTRRTSIERYRNIGISAHIDAGKTTTTERILFYTGITHKLGEVHEGAATMDWMEQERGITITSAATTAFWRGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYGVPRIAFVNKMDRVGADFFRVQRQIVERLKGDAVPIQIPVGAEDHFEGVVDLVKMKAIIWDDASQGVRFEYRDIPPELQAQAEQWREKMIEKAAEANEALLEKYLSGQPLSEDEIKSGLRARTVANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPADVPAIIGHDERDREIERHPADDEPFSALAFKIMTDPFVGQLVFFRVYSGVVKSGDSVLNPLKSKKERLGRILQMHANERREISEVYAGDIAAAVGIKEITTGDTLTDPAHVIILERMTFPEPVISQAVEPRTKADQEKMGIALNRLAQEDPSFRVRTDEESGQTIISGMGELHLEILVDRMKREFGVEANVGKPQVAYRETIRSTVTDVEGKFVKQSGGRGQYGHVVLKLEPQEQGKGYEFVDAIKGGVVPREFIPAVDRGVRETLNTGVLAGYPVVDVKVTLVFGSYHDVDSNENAFRMAASMAFKEGMRRAKPVLLEPMMHVEVETPEDFTGNVMGDLSSRRGMVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSLTQGRATYSMEFKHYAEAPRQVAEQIIAARGSGAAARG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 2, EF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCX6_CENSU
Sequence: KEGYLVNSYTGCKFECFKLGDNDYCKRECKQQYGKSSGGYCYAFGCWCTHLYEQAVVWPLPNKTCN
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Beta-toxin Css6, Css VI, CssVI.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CYF_OSTTA
Sequence: MKKNLFLVSVFASLFVGTANNALAYPMYAQQGYENPREATGRIVCANCHLAQKPVDIEVPQAVLPDSVFEAVVKIPYNQEVKQVLGNGKKGGLNVGAVLILPDGFTMAPADRMSAELKEKVGKLYFQPYSEDKQNILIVGPVPGKKYSEMTFPLLSPDPATNKKVNYLTYPIYLGGNRGRGQVYPDGSKSNNTVYNAAAAGKIAAINPTEKGTDVVIDKVDGGSVTVAIPSGPDLLVSVGDTVAADQPITNNPNVGGFGQGETEIVLQNPARLQGLVIFLGFVLIAQVFLVLKKKQFEKVQLSEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: WDR38_HUMAN
Sequence: MNSGVPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSKSPRDPQT
What are the official names of this protein?
WD repeat-containing protein 38.
Protein: RS2_FRATT
Sequence: MSLMKEMLSVGVHFGHKKAFWNPQMKEYIFGINHGVHIINLEKTVPLFQDAVNFVGKTVANGGKILFVGTKRQAQDIVEAEAKRCGMSFVSHRWLGGMLTNYKTVRQSIKRLAQLEKMREDGTLESLTKKEMLQNIRTIEKLEKVLGGIKEMGGLPDAIVVIDSNKEHIAIQEAQKLGIKVVAIVDTNSNPEGIDYIIPGNDDAVKSISFYMKKFADAVIDAQGLDRAVEAKADEAAQA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RNY_BACFN
Sequence: MLVTIVASIACFIVGGILSYVLFKYGLKAKYDNVLKEAETEAEVIKKNKLLEVKEKFLNKKADLEKEVALRNQKIQQAENKLKQREMVLSQRQEEIQRKRAEADAVRENLEAQLGIVDKKKEELDKLQHQEIEKLEALSGLSADEAKERLVESLKEEAKTQAQSYINDIMDDAKLTASKEAKRIVIQSIQRVATETAIENSVTVFHIESDEIKGRIIGREGRNIRALEAATGVEIVVDDTPEAIVLSAFDPVRREIARLALHQLVTDGRIHPARIEEVVAKVRKQVEEEIIETGKRTTIDLGIHGLHPELIRIIGKMKYRSSYGQNLLQHARETANLCAVMASELGLNPKKAKRAGLLHDIGKVPDEEPELPHALLGMKLAEKFKEKPDICNAIGAHHDEIEMTSLLAPIVQVCDAISGARPGARREIVEAYIKRLNDLEQLAMSYPGVTKTYAIQAGRELRVIVGADKIDDKQTENLSGEIAKKIQDEMTYPGQVKITVIRETRAVSFAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MTNB_XENLA
Sequence: MYYCNRDNCNQTDNAKDKAHPRNLIPELCRQFYNLGWVTGTGGGISLKYGDEIYIAPSGVQKERIQPDDLFVCDIDEKDISCPPPYRNLKKSQCTPLFMNAYTMRDAGAVIHTHSKAAVMATLMFPGKEFLITHQEMIKGIKKGTSGGYYRYNDMLAVPIVENTPEEKDLKERMARAMTEYPDTCAVLVRRHGVYVWGDTWEKAKTMCECYDYLFDIAVQMKQHGLDPSAVPTEEKGIV
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).  Functions in the methionine salvage pathway.  May play a role in apoptosis.
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase, APAF1-interacting protein homolog.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARR7_ARATH
Sequence: MAVGEVMRMEIPAGGDLTVTTPELHVLAVDDSIVDRKVIERLLRISSCKVTTVESGTRALQYLGLDGGKGASNLKDLKVNLIVTDYSMPGLSGYDLLKKIKESSAFREVPVVIMSSENILPRIQECLKEGAEEFLLKPVKLADVKRIKQLIMRNEAEECKILSHSNKRKLQEDSDTSSSSHDDTSIKDSSCSKRMKSESENLFSLL
What is the function of this protein?
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
What are the official names of this protein?
Two-component response regulator ARR7.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-A subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECY2_LACJO
Sequence: MEKKNLLNVIKKVSFSLFIVIIYVMGLYIPLPFAEGTKQYMEAVKNTPISILGAFSGANFTRISIFSIGLNPLMFSMLIIQLLSFTHSFGFDALSPKQVQYLMQFLTMIITIIQAALLVFAFTNRRNGLEDFEMILILSAGSCLVVWLCYRNMKYGVGASAPVILTSILNGAIPNIISNVKLLLTMKYAWIWLAALAIFILLLIKFWLAFTKAYYPLKVVNPSLPASSNLMTVPLGLNMAAMMMYMVGMAILTLPLMVGRYFSSSSLINNWVFQASFSAVMGILIFYFFTFVNFDPKEQAKSFRNNHYYIPNIAPGRPTQRYLNRLIWIIAFPGAVLNAFQLVFGLYGGNFLGNYAGFAIIPMNVVMITMFMGGIKDQIDTILFPYRYDRLLKDN
What is the function of this protein?
Part of the accessory SecA2/SecY2 system specifically required for export of possible cell wall proteins.  The central subunit of a protein translocation channel.
What are the official names of this protein?
Accessory Sec system protein translocase subunit SecY2.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family. SecY2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NTPPA_SCHPO
Sequence: MSNEKMDTSPPSYDSHFTLETSMHRQLKDKRIILASGSPRRKQLFEQMGFPNVETCVSGFPEDLNKSMYITPWEYAADTSVQKAIAVYEKLAAEEDSPDIVVSADTILILDSEIMEKPNDPKHHLAMLKKLRNSKTPHKVFTAVSVIVPMEVPIHPGYVMKTHLEETQVKFDPSITDEFLEAYVRCGEGSDKAGGYAIQGHGALLIESIIGDFSNVVGLPIRATFKLMEEALEQGDADNYD
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Maf-like protein C3G6.03c, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TONB_ECOLI
Sequence: MTLDLPRRFPWPTLLSVCIHGAVVAGLLYTSVHQVIELPAPAQPISVTMVTPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKRDVKPVESRPASPFENTAPARLTSSTATAATSKPVTSVASGPRALSRNQPQYPARAQALRIEGQVKVKFDVTPDGRVDNVQILSAKPANMFEREVKNAMRRWRYEPGKPGSGIVVNILFKINGTTEIQ
What is the function of this protein?
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc. ).  In the absence of TonB these receptors bind their substrates but do not carry out active transport.  TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection.  It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.  Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).
What are the official names of this protein?
Protein TonB.
What is the protein family that this protein belongs to?
Belongs to the TonB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: ATP6_PIG
Sequence: MNENLFASFIAPTMMGLPIVTLIIMFPSLLFPTPKRLINNRTISIQQWLIQLTSKQMMAIHNQKGQTWSLMLMSLIMFIGSTNILGLLPHSFTPTTQLSMNLGMAIPLWSATVFTGFRYKTKTSLAHFLPQGTPALLIPMLVIIETISLFIQPVALAVRLTANITAGHLLIHLIGGATLALLNINTMTAFITFTILILLTILEFAVALIQAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UGPB_PECAS
Sequence: MFNNTIRKTHAIRTAAACVAFALMSAGAQAATDIPFWHSMEGELGKEVNSLADRFNKEHTDVKIVPVYKGNYEQNLAAGIAAYRAGNAPAILQVYEVGTATMMASKAIKPVYEVFKDAGINFDESVFVPTVSGYYTDAKSGHLLSQPFNSSTPVLYYNKDAFKKAGLDPEQPPKTWQQMADYTAKLRSAGMKCGYASGWQGWIQIENFSAWNGLPVATKNNGFDGTDTVLEFNKPTQVKHIQLLQDMNKKGDFTYFGRKDEPTEKFYNGECAMTTASSGSLANIREHAKFNYGVGMMPYDADAKGAPQNAIIGGASLWVMGGKDAATYKGVAEFMQFLAKPENAAEWHQKTGYLPITTAAYELTQKQGFYEKNPGADIATRQMLNKPPLPFTKGMRLGNMPQIRTVVDEELESVWTGKKTPQQALDSAVERGNALLRRFEQSTK
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Binds G3P.
What are the official names of this protein?
sn-glycerol-3-phosphate-binding periplasmic protein UgpB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: AIM21_CANDC
Sequence: MSDLEPSESLNHESDSHLEQLKPSTTPSIPARPQSRPQKQTTTTTTKVPTDQDSNDKTPLEKPQDELDQLAHEIEKVLTDPVIPPRPQHGSSAKPNETQTEHKEQDFGSAHPVIPSRPTNKKETIETEMVDQNNGLESKSDSTANKESLENQVPIDEDSTHVKPSIPNVPSRPQNRDLDSSEVDNTKASTTPSIPARPQRQTAPTQNEHKPQVSNTPVIPTRPQTKTEKLHLNEELDKLDGESSSKNQENKRHTDDNNTSKPIYEAESIVPPEEKEGETANKQALPTTSTDPPAEPTASTRGFRLPLHMQQSSGPISTSTPVTGSEAELNSLDNSNTFGDGEITPGNSDTKATFKSDEDVENNNRTDSSSFDDDMETISQDQEDREEDRRHRQETTTGENVQESEDPQFETTIIESGEIEERDGDDTDSGELYSEQQQNKEKEDVVPATSTPKIPQRPPKKQSLSRATTDDSLTSLDNTSKPPKPVVPKRPTSEESSSNLEPTIPTRPSIKKAPSIGESDPEPIVPNRPGNKELESIPRDTQTSIKSKPPPPKPKKLSSKIAAFQQQLFNPMNASSEEDVGSTGSKQPEPGIRKRSTENSILSRFGGKAIPLPGMFNPNQMPKPSISHGEETSDDKEEKEEKEENVTANVPVRRTRGPRGKKLPKAVADAEIKTESRFTIESGKLWSLEFKREIKEEKEIGHSDLEKSKILVDDVEADGDGEEKAAENEVIESQENTIGDKLEHNDVVNIASAAADIDNDGDVDDDDDDDVPPEVNERFIKDEEISNVGIERTIASETTTEKHSTDEEVEEEEEELEVDSVDIPIRRVTVNTVDTIEDQKDVDDEPL
What is the function of this protein?
Involved in mitochondrial migration along actin filaments.
What are the official names of this protein?
Altered inheritance of mitochondria protein 21.
What is the protein family that this protein belongs to?
Belongs to the AIM21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch. Note=Cortical actin patches.
Protein: RNH2_SOLUE
Sequence: MRPIPAGGKFRCEATLERELRARGFRAVAGVDEVGRGALFGAVFAGAVILSEERPIRGLNDSKQLDPERREVLAGRIRERAVAWSIAAVDASTIDSINIYQASRMAMRIAVSRLSPAPDFLLVDAVPLEFAVPQRALIKGDERCHAIAAASILAKVARDECMRVWDKVFPEYGLASHKGYSTPEHYRAIEQYGPTPLHRLSFEPVRAHSRFPLDHDRQLDLFDTAGAA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDF1_SCHPO
Sequence: MLSCSSFLIFFLFSWVLLPMKSFAIPIISLDKVRLAINDGASEQLPVVIWHGLGDTPTSFTLTEVSQRVQKLTKGAVYAIRVGDNEFEDIKAGYLGKLEDQLDEVCDLIGNEDSLSNGFYALGLSQGGLFLRALAQTCDAAKIRSLITLGSPHSGINTIPGCSPTNLICKAVVHSILGLGIWHSWIQNHVVQAQYYRTEKQYDKYLENNKFLTHLNNEVLHDNYTRNIEKLKELDNLVAVSFERDDIVEPPYSTGFGWINETTGENIEMEDFVLYESLGLKDLVNQGKLETISFPGRHLQMRWGDFDALVLKYFKDEKEEKTELEESTRPSNFLSTYFVSPLVSAIDGTVDYLHGKSLFPEKRNFKELTMRKRSIVTPEDSEEVYPYISEFVAASNVSEEKGPKSFANLAFITIFSHFFYHIDDMWRSTLGLFSLIPQIIGIIYLTVMFTGRELDTFMQFGGQVVNEFINYVVKVSLKYPRPADIEYGVGYGMPSSHSQFMGFFSAYMIAWDYKYRRSQCFSMLSFAKYAIYLTLSTFVCSSRYLLDFHYLTQVVYGYMIGFGVGLFWVYLVGKLRSLGVTKWLLSLPPLQFFYIKDTIPHSKDNHKRQWLESKQFKNQKSN
What is the function of this protein?
Essential protein.  Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during vacuolar degradation.  Required for efficient N-glycosylation.  Necessary for maintaining optimal levels of dolichol-linked oligosaccharides.
What are the official names of this protein?
Palmitoyl-protein thioesterase-dolichyl pyrophosphate phosphatase fusion 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the dolichyldiphosphatase family.
What are the subcellular locations of this protein?
Vacuole. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PGP_HALS3
Sequence: MDTADPPLAVDIDGTLSRADRSIDGRVLDVLRGWDGPVVVATGKALPYAVALCQFAGIDERVIAENGGVAYVGDELLHFGDSRAVEQVAAAFEDAGHDIGWGDADLTNRWRETELAVSREQPLDVLSALAADHGLHVVDTGFAYHVKPESMSKGNALPAVAARLGVTAGDFVAVGDSANDVELFEAVGESYAVGNADDHAKGAAETVLSETHGDGFLAAVDRIRS
What is the function of this protein?
Catalyzes the dephosphorylation of 2-phosphoglycolate.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the archaeal SPP-like hydrolase family.
Protein: GCH1L_VIBCH
Sequence: MNNLQLEALLNETLSPQLIKDYCPNGLQVEGKVEVKRIVTGVTASMALIEAAIELKADALLVHHGYFWKNEPEAIRGMKGRRIRTLIQNDLNLYAYHLPLDIHPQLGNNAQLAQRLGICVDGGLEGHPQSVAMFGHFLQPLTGEELAHRIGQVLNRTPLHIAPDQADKLIETVGWCTGGGQDYIELAASRGLDAFISGEISERTTYSAREQSIHYFSAGHHATERYGIKALGEWLAENHGFDVTFIDIDNPV
What are the official names of this protein?
GTP cyclohydrolase 1 type 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
Protein: PGAD_ECOLI
Sequence: MNNLIITTRQSPVRLLVDYVATTILWTLFALFIFLFAMDLLTGYYWQSEARSRLQFYFLLAVANAVVLIVWALYNKLRFQKQQHHAAYQYTPQEYAESLAIPDELYQQLQKSHRMSVHFTSQGQIKMVVSEKALVRA
What is the function of this protein?
Required for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide.  May assist the glycosyltransferase PgaC in the polymerization of PGA.
What are the official names of this protein?
Biofilm PGA synthesis protein PgaD.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HISZ_BRUSI
Sequence: MVGSRTSPIFNALRVELNAREAELVEIPLIQPADPFLDMAGEDLRRRIFLTENENGDSLCLRPEFTIPVCRNHIALNAATPKRYAYLGEVFRQRRDGAAEFLQAGIEDLGAADEAASDARSLADALSCVKAIAPDAPLEIVLGDQSVFAGMLKALGLPQGWRKKLLRSFGDAHSMDLALAELTGTQRRDPLPESLAVLVAEGDEIGLARMLEAEMLEAGISPGAGRTPVEIARRLIEKEDLAATHFPAAALDLLRQFLAIRVSLDTAAVTLRAFAADNALDLGAVLQKFEARADAIAQAGIEMKDIIYDASFGRPLDYYTGLVYEIRDASNRQDGVLAGGGRYDRLLTMLGACEAIPGVGFSIWLDRLQALAGEKQ
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CWC22_CANAL
Sequence: MENSTTTTTTTTVTQPDESYQRTKWIETKKNIKQLLQQLTPSNIKQTVLQLFQINLLRYQGLFIREIMKQQIRITTNAELYGSLISIINSKIPEIGELLINRLVLQFKKNYLQNNKNLINSSIIFICQLINQQVLNEILILQILQMLLESNVPNNNNNNNNNNIELAIMVLKQTGSYLFKHSNTALIMILNRLKDILQDGANANANGGNGGVGLSSWNRKSIEYILKLARNDFKNISIIKNGLDLVETEDKETHVITLEDKLYSRDHLNVFSVDEEYLDHENEYIELKKEILGETDHEDENENEIQVIETTKNYEEKITDMSQSELLQYQKTVYLTIMSSMSSDEAVHKLLKLNFKSKIKNKTKNKTKTKTNSNDNEILADMVIKCCSQEKTYSKYYGIIGEKLISRNDHWHNLFIKLFKYYYDIIENFETNSLRNLGKFFGHLFASDKLALDQAWSNIKLTEQDTNPAKRILLKFIFQEMIEELGINEVKERLINDDYLKPYIKGIFPVINVDGKDADAIRFSINFFTAIGLGVLTEEMRYVLDNLSEPEEEDDRGRSRSRSYSRSASSSSYNSRSRSYSRSQSRSSRSPNPRGRQRFKTKKHNHNESRTPSRENLKRKRSESVTDRNGNNNNNNNNNLQDLLNNLK
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC22.
What is the protein family that this protein belongs to?
Belongs to the CWC22 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TIG_AERHH
Sequence: MQVSVETTQGLERRLTITVPAATVDAAVRKELNGLAKTRRIDGFRPGKAPVAIIKKMFGAMAHARVADEMMQSNFIKAIIENKLSPAGAPTMDPKEIQEGQDFEFTATFEVYPEFEVAGLETIKVEKPVATVKDEDLGNMIDTLRKQHATWSEVDAAAADGMRVTMDFVGSIDGEEFDGGKAEGFNLVLGAGRMIPGFEDAIMGKKAGDEFTIDVTFPADYHAENLKGKAAKFASKLNKVEEQILPELTEEFVKRFGIESGNVEELKAEVRKNMERELAQALKNSVKEQVLNGLVEANQIDLPKAAVAQEIDALRQQALQRFGGFQGGNAPELPAELFQGQAERRVRVGLLLGDVIRTNEIKADEARVNSIIESMATAYEDPKEVIEYYQKNEQMLNGVRNLAVEDQAIDLILSKAQVTEKEVAFDEVINKSGAAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RPC6_HUMAN
Sequence: MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLEF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  May direct RNA Pol III binding to the TFIIIB-DNA complex.  Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus (PubMed:30211253).  Acts as nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response.  Can sense non-self dsDNA that serves as template for transcription into dsRNA.  The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.  Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC6, RNA polymerase III subunit C6, DNA-directed RNA polymerase III subunit F, RNA polymerase III 39 kDa subunit, RPC39.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.