PharMolix/UniProtQA huggingface dataset:
Protein: SNAI2_BOVIN
Sequence: MPRSFLVKKHFNASKKPNYSELDTHTVIISPCLYEGYPVPVIPQPEVLRSGAYSPIAVWTTASPFHAPLPAGLSPLSGYPASLGRVSPPPPSDTSSKDHSGSESPISDEEERLQSKLSDPHAIEAEKFQCNLCNKTYSTFSGLGKHKQLHCDAQSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCSHCSRAFADRSNLRAHLQTHSDVKKYQCKSCSKTFSRMSLLHKHEESGCCAAH
What is the function of this protein?
Transcriptional repressor that modulates both activator-dependent and basal transcription.  Involved in the generation and migration of neural crest cells.  Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells.  Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells.  In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription.  Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes.  Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes.  Represses E-Cadherin/CDH1 transcription via E-box elements.  Involved in osteoblast maturation.  Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts.  Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts.  Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).
What are the official names of this protein?
Zinc finger protein SNAI2, Neural crest transcription factor Slug, Protein snail homolog 2.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity).
Protein: V12_BPT3
Sequence: MMMGRIYSGNLNDYKDAVARLQEDHDVTVKMESFSYENPAKMCRSCGEVLSVFTRSGHLVASRTFEHSDSDVQINAQTAWLRKVHSELKHWK
What is the function of this protein?
This is an inhibitor of the host (E. coli) dGTP triphosphohydrolase (dGTPase).  It is implicated in DNA replication.
What are the official names of this protein?
Gene 1.2 protein.
Protein: IL18_MOUSE
Sequence: MAAMSEDSCVNFKEMMFIDNTLYFIPEENGDLESDNFGRLHCTTAVIRNINDQVLFVDKRQPVFEDMTDIDQSASEPQTRLIIYMYKDSEVRGLAVTLSVKDSKMSTLSCKNKIISFEEMDPPENIDDIQSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTLTNLHQS
What is the function of this protein?
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:26638072, PubMed:26638073).  Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (By similarity).  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (By similarity).  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:30392956).
What are the official names of this protein?
Interleukin-18, IL-18, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The precursor is cytosolic (By similarity). In response to inflammasome-activating signals, cleaved and secreted (By similarity). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:30392956). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (By similarity). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (By similarity).
Protein: ILVB_ECOLI
Sequence: MASSGTTSTRKRFTGAEFIVHFLEQQGIKIVTGIPGGSILPVYDALSQSTQIRHILARHEQGAGFIAQGMARTDGKPAVCMACSGPGATNLVTAIADARLDSIPLICITGQVPASMIGTDAFQEVDTYGISIPITKHNYLVRHIEELPQVMSDAFRIAQSGRPGPVWIDIPKDVQTAVFEIETQPAMAEKAAAPAFSEESIRDAAAMINAAKRPVLYLGGGVINAPARVRELAEKAQLPTTMTLMALGMLPKAHPLSLGMLGMHGVRSTNYILQEADLLIVLGARFDDRAIGKTEQFCPNAKIIHVDIDRAELGKIKQPHVAIQADVDDVLAQLIPLVEAQPRAEWHQLVADLQREFPCPIPKACDPLSHYGLINAVAACVDDNAIITTDVGQHQMWTAQAYPLNRPRQWLTSGGLGTMGFGLPAAIGAALANPDRKVLCFSGDGSLMMNIQEMATASENQLDVKIILMNNEALGLVHQQQSLFYEQGVFAATYPGKINFMQIAAGFGLETCDLNNEADPQASLQEIINRPGPALIHVRIDAEEKVYPMVPPGAANTEMVGE
What are the official names of this protein?
Acetolactate synthase isozyme 1 large subunit, AHAS-I, Acetohydroxy-acid synthase I large subunit, ALS-I.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: PYRR_STRPC
Sequence: MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQERLHQLEGLDLPIGELDIKPFRDDMRVEEDTTLMSVDITGKDVILIDDVLYTGRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVEVDGRDRVSIIDPT
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: UNG_BACC4
Sequence: MENVLKNDWEPLLAPEFEKEYYLTLSSFLTEEYSTHVVYPKVEDIFNALQYTSYENTKVVILGQDPYHGPNQAHGLSFSVQPGVKTPPSLLNMYKELRDEYGYEIPNNGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVIFILWGRHAQAKKKLITNPNHHIIESVHPSPLSARRGFFGSKPYSKINTILANMGEREIDWEIPNL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_TROWT
Sequence: MFAVVKASGFQRLVEVGSVISIDPTNVDSGGFVHFPVLLLVDGAEVVSDPDKLRLARVSAKFLRKLRGPKVRIHKFKNKTGYHKRQGHRQGVYVFSVTSIERGD
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: SYL_PORGI
Sequence: MEYNFQEIEKRVQGQWRKDKVYRVAEDTSKKPFYVLDMFPYPSGAGLHVGHPLGYIASDIFSRYKRLRGFNVLHPMGYDAFGLPAEQYAIQTGQHPEKTTEENTARYREQLDKIGFSYDWEREIRTCDPNYYKWTQWAFLKMFDSYYCNQAQQARPISELIEVFARQGNDGLNVACGEGVRFTAEEWTAMSEKEQQEILMNYRLAYLGDTMVNWCPALGTVLANDEVKDGVSERGGHPVEQKKMRQWCLRVSAYAERLLHDLETLDWTESLKETQRNWIGRSEGAEMEFRLAGKDCTFTIFTTRADTIFGVTFMVLAPESELVEEVTTEEQRAAVETYLTETKRRTERERISDKRVSGVFSGSYAINPLTGKEIPIWISDYVLAGYGTGAIMAVPAHDTRDFAFARHFDLPIVQVVVPEGEPATDPATWEDAKDSKSGIMVNSDFLNGLSVEDAIAQTKEYIREKHLGCVKVNYRLRDAIFSRQRYWGEPFPIYYKEGMPHALDEDRLPLRLPEVDKFLPTESGEPPLGRATGWHTAEGYPYELSTMPGFAGSSAYYLRYMDPQNDTALVSRSANEYWRHVDLYIGGTEHATGHLIYSRFWNKFLFDLGIVCEAEPFRKLVNQGMIQGRSNFVYRIKNTNTFVSYGLREQYEVTPLHVDVNIVSNDQLDIDRFRAWRPEYTSAEFILEDGKYICGWAIEKMSKSMFNVVNPDDIIARYGADTLRLYEMFLGPLEQSKPWDTNGIDGVHRFLKKFWALYYNTDGIRVTDTAPTKEELKSLHKLIKKVGQDIESFSFNTSIPAFMICVNELTAAKTTSRAILCPLLTVLSPFAPHITEWLWQELGVEGSIVTATWPEYNEEYLVESCVRYPVSFNGKVRFNIELPADMSKEDVEQAALIAPEAARWLEGKSPKKVIVVPGRIVNVVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECX_MYCTO
Sequence: MTVSCPPPSTSEREEQARALCLRLLTARSRTRAELAGQLAKRGYPEDIGNRVLDRLAAVGLVDDTDFAEQWVQSRRANAAKSKRALAAELHAKGVDDDVITTVLGGIDAGAERGRAEKLVRARLRREVLIDDGTDEARVSRRLVAMLARRGYGQTLACEVVIAELAAERERRRV
What is the function of this protein?
Binds to RecA inhibiting ATP hydrolysis and the generation of heteroduplex DNA.  It might act as an anti-recombinase to quell inappropriate recombinational repair during normal DNA metabolism.  It is essential for cell survival (By similarity).
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3A_MALGO
Sequence: MAVGKNKKLSKGKGNKKRAVDPFTRKEWYDIKAPVFFENRNVGKTIVNRSQGLKNASDALKGRILEQSLADLNKDDEQAYRKFQLRVDEVQGRNCLTNFYGMSFTSDKLRSLVRKWQSLIEAHQDIRTTDGYLLRVFAIGFTRRRANQVKKTTYAKSSQIHAIRKKMFEVIQRESSSCDLREFVAKLIPEVMGREIEKSTQGIYPLKDVFIHKVKVLKRPKFDVNKLYELHGGASVVGAEDVGTKIKSGEFKEPVPQASV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOVHK_PSE14
Sequence: MSEEKARVDNAATGDIQHQGKDIFFAAVETTRMPMIVTDPNRADNPIIFSNRAFLEMTGYSSEEIIGTNCRFLQGPETDRAVVQSIREAIDERVDISTEILNYRKDGSTFWNALFISPVYNDAGDLIYFFASQLDISRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMGGYIDLIGSAAEKPTIDVQRVQRSVHHAKSAVERASTLTKQLLAFARKQKLQGRVLNLNGLVSSTEPLIERTFGPHVTIETDLDPALKNCRIDPTQAEVALLNIFINARDALVGRPDPKISIETRNLVVDELANMSYDGLLPGRYVSIAITDNGIGMPSSIRDRVMDPFFTTKEEGKGSGLGLSMVYGFAKQSGGAARIYTEEGVGTTLRLYFPVDEAMLTHAEPPKAVDRRIGSCERILIVEDRPDVAELAKMVLDDYGYICEIVLNAREALKKFESGSRYDLLFTDLIMPGGMNGVMLAREVRRRYPKIKVLLTTGYAESSIERTDIGGSEFDVVSKPCMPQDLARKVRQVLDGPNGIA
What is the function of this protein?
Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light.
What are the official names of this protein?
Blue-light-activated protein.
Protein: PP250_ARATH
Sequence: MLLNLRLDGSSLHVLCSTKTLPISSPLDKFPSFKKLKQNYVPGTHESDKGPQRSTRNGDRGCGTVAHEVVAGKNLLLVNPSNGCVGKSGIIDGFVDKRSKDARFGGNGLVSEVHTKCSTKRLSYGGCIPAILEALDSIEDVEDALSPWAERLSNKERTIILKEQIHWERAVEIFEWFKSKGCYELNVIHYNIMLRILGKACKWRYVQSLWDEMIRKGIKPINSTYGTLIDVYSKGGLKVHALCWLGKMSKIGMQPDEVTTGIVLQMYKKAREFQKAEEFFKKWSCDENKADSHVCLSSYTYNTMIDTYGKSGQIKEASETFKRMLEEGIVPTTVTFNTMIHIYGNNGQLGEVTSLMKTMKLHCAPDTRTYNILISLHTKNNDIERAGAYFKEMKDDGLKPDPVSYRTLLYAFSIRHMVEEAEGLIAEMDDDNVEIDEYTQSALTRMYVEAEMLEKSWSWFKRFHVAGNMSSEGYSANIDAYGERGYLSEAERVFICCQEVNKRTVIEYNVMIKAYGISKSCEKACELFESMMSYGVTPDKCTYNTLVQILASADMPHKGRCYLEKMRETGYVSDCIPYCAVISSFVKLGQLNMAEEVYKEMVEYNIEPDVVVYGVLINAFADTGNVQQAMSYVEAMKEAGIPGNSVIYNSLIKLYTKVGYLDEAEAIYRKLLQSCNKTQYPDVYTSNCMINLYSERSMVRKAEAIFDSMKQRGEANEFTFAMMLCMYKKNGRFEEATQIAKQMREMKILTDPLSYNSVLGLFALDGRFKEAVETFKEMVSSGIQPDDSTFKSLGTILMKLGMSKKAVRKIEEIRKKEIKRGLELWISTLSSLVGIGDCVDEL
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At3g23020.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: DNAK_SHEB9
Sequence: MGKIIGIDLGTTNSCVAVLDGGKARVLENAEGDRTTPSIIAYTDDETIVGSPAKRQAVTNPTNTFFAIKRLIGRRFKDDEVQRDVNIMPFKIIAADNGDAWVESRGNKMAPPQVSAEILKKMKKTAEDFLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGIDKKQGDNIVAVYDLGGGTFDISIIEIDSNDGDQTFEVLATNGDTHLGGEDFDNRLINYLADEFKKEQGLDLRKDPLAMQRLKEAAEKAKIELSSTNHTEVNLPYITADATGPKHLVIKITRAKLESLVEDLIIRTLEPLKVALADADLSVTDINEVILVGGQTRMPKVQEAVTNFFGKEPRKDVNPDEAVAVGAAIQAGVLSGDVKDVLLLDVTPLSLGIETMGSVMTKLIEKNTTIPTKAQQVFSTADDNQSAVTIHVLQGERKQASANKSLGQFNLDGIEPAQRGQPQIEVMFDIDADGILHVSATDKKTGKKQNITIKASSGLSEEEVAQMVRDAEAHADEDKKFEELVQSRNQADGLVHATKKQVEEAGDALPSEDKEKIQAAMDAVDTAIKGNDKEAIEKATQELIEASAKLMEIAQAKSQAQGGDNADAGKQANATADDVVDAEFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: P5CS_VIGAC
Sequence: MESAVDPSRGFMKDVKRVIIKVGTAVVTREEGRLAVGRLGALCEQIKQLNSLGYDIILVSSGPVGIGRQRLRFRKLINSSFADLQKPQLELDGKACAAVGQNSLMALYDTLFTQLDVTSAQLLVTDNDFRDKDFRKQLTETVKSLLALKVIPVFNENDAVSTRKAPYEDSSGIFWDNDSLSALLALELKADLLVLLSDVEGLYSGPPSDPHSKLIYTYNKEKHQNEITFGDKSRVGRGGMTAKVKAAVHAAEAGIPVVITSGFAPENIINVLQGQRIGTLFHKDAHEWAQVKEVDAREMAVAAGNVREGSRRYLQRKGNKILLKIADALEANEKIIRIENEADVTAAQEAGYEKSLVARLALKPGKIASLANNMRIIANMEDPIGRVLKRTELSDGLILEKTSSPLGVLLIVFESRPDALVQIASLAIRSGNGLLLKGGKEAKRSNAILHKVIIEAIPDNVGGKLIGLVTSREEIPELLKLDDVIDLVIPRGSNKLVSQIKSSTKIPVLGHADGICHVYVDKSANVEMAKRIVLDAKVDYPAACNAMETLLIHKDLIEKGWLKEIILDLRTEGVILYGGPVASSLLNIPQAHSFHHEYSSLACTAEIVDDVYAAIDHINLYGSAHTDSIVAEDNEVANVFLRQVDSAAVFHNASTRFSDGARFETRRRGWN
What is the function of this protein?
P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants.
What are the official names of this protein?
Delta-1-pyrroline-5-carboxylate synthase, P5CS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
Protein: EFTU_CELLY
Sequence: MAKETFDRSKPHLNIGTIGHVDHGKTTLTAAITTVLANAGLSELRSFDSIDNAPEEKERGITINTSHVEYSTANRHYAHVDCPGHADYVKNMVTGAAQMDGAILVVAATDGPMPQTREHILLGRQVGIPRIVVFLNKVDMVDDEELLELVEMEVRELLSFYEYDGDNGPVVSGSALGALNGEQKWVDTVMELMEAVDNWIELPKRDVDKDFLMPVEDVFTITGRGTVATGRIETGVANTGDAVDIIGMGADKLASTITGVEMFRKILDRGEAGDNVGILLRGIEKSQISRGMVICKPGSVKPHSKFEAEVYILKKEEGGRHTPFHNNYRPQFYVRTTDVTGTISLPSGVEMVMPGDNLTITVELLSPIALSEGLRFAIREGGRTVGAGQVTKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_AQUPY
Sequence: MGQKTHPIGFRLGVIKDWPSKWYPPKKDYAKLLHEDLKIKNYIKKRYKVAGVSKVEIERIVDKVRIKIHTAKPAIVIGRRGQEVDRLKKTIERMLPGKEISISVLEVKVPELDAQLVAEDIALQIERRVSHRRAMKRAIDNALKAGQKGVKVQVKGRIGGAARARKEWFLVGRMPLQTLRADIDYGFATAYTKYGILSVKVWIYKGDVLKGGKEEILKKIEEEIKQAAKEG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PROA_PSESM
Sequence: MTESVLDYMTRLGRAAREASRVIGRASTAQKNRALQATAAALDEARDELSAANALDLAYGQANGLEPAMLERLALTPARIDSMIVGLRQVASLADPVGAIRDMSYRPSGIQVGKMRVPLGVVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRAIAACIARGLAEAGLPAAVVQVVETTDRAAVGALITMPEYVDVIVPRGGKGLIERVSRDARVPVIKHLDGICHVYVSAHADLPKAQKIAFNAKTYRYGICGAMETLLVDQTIAADFLPAMAAQFREKGVELRGCERTRELIDVMPATEDDWHTEYLAAILSIRVVSGLDEAIEHINHYGSHHSDAIVSDHQSQIRRFMAEVDSSSVMVNAPTSFADGFEYGLGAEIGISTDKLHARGPVGLEGLTCEKYIVIGDGQLRGHA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXX_CLAMS
Sequence: MNVAVQSRVDRETIGVARKTKAYVALTKPRVIELLLVTTAPVMILAQGGWPNPWLILGVLVGGTLSAGSANAFNCYIDRDIDRVMKRTQRRPLVTGELTDREALVFAWIIGVASIIWLGVISNWLAAALSLAAILFYVFVYTLWLKRRTPQNIVWGGAAGCMPVLIGWAAVTGDISWAPVILFMIVFLWTPPHYWPLSMKYRDDYASVNVPMLAVVRGRAAVGLQTILYSWATLACSLLLIPVAGMGLVYTLAALAGGGWFVYETHRLYDLAVRHEPIKPMRVFHASISYLSLLFLAVGIDPLLPF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YVDD_VACCC
Sequence: MIVAWFLLLILLEKHGLPMTQGSVNFLILSDLIFFDPLQAKSGSSLQNTDLFKCMLAINGLGPLSNTSVKIV
What are the official names of this protein?
Uncharacterized 7.9 kDa protein.
Protein: DHAS_BUCAI
Sequence: MIKIVGLVGWRGMVGSVLLKRMQEENDFSRIKPVFFSTSQFGQDGPIINNISYNILENAYNIDVLKEMDIIITCQGGSYTKEIYPTLRKNGWKGYWIDAASNLRMKNDSVIILDPVNYNVIEDSINKGIRTFVGGNCTISLMLMSLGGLFQTELVEWIAVSTYQAASGAGARHMIELLNQMGILYKSVETDLLKGSHSILSIEDKVTKISRSVNFPVKNFSVPLAASLIPWIDTEMSNGQSREEWKGQAETNKILGTKDTILIDGTCVRIGSLRCHSQSFVIKLKKDVSLEDIEEIIRNHNKWVDVIPNSIQDTLLKLTPSSVTGTLNIPIGRLRKLNMGKKYLSAFTVGDQLLWGAAEPLRRMLNILINI
What is the function of this protein?
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
What are the official names of this protein?
Aspartate-semialdehyde dehydrogenase, ASA dehydrogenase, ASADH, Aspartate-beta-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aspartate-semialdehyde dehydrogenase family.
Protein: OBLE_EMEVA
Sequence: MDSQFLSVSRPQLDVSAWTPQKWFVQGALRSFEEWSAWQYIVTLLIAIITYDQVMYIWRKASIAGPAFKIPLMGPFLQALHPRFESYLEQWASGPLSCVSIFHKFVVLASDRDLAHKVFKSPTYAEPCIVPIAKDILGHKAWVFLQGKAHAEYRRGLTPLFTNKAMETYLPAQERVCADYFDKFVAASAANNGQPREFMTLFREINCALSLRTFFGDYISQDAVKKIADDFYLATAALELVNVPLSMYIPGTKPWRGKRTADAVHAEFARCAAACKANMATGSEPTCIVDHWVLHMMESSRYHARVAAGEEGVEKPTNVIREFSNQEISETLFTFLFASQDASSSATTWLFQILAQRPDVLSRLREENLAARNGDRFKPFDLPMLESLPYTTAVIKELLRHRPPVIFVPYLATKPFPITPSYTVPKNSMIIPSCYPALHDPEAYPNPEVFDPDRWITGDAEKQTKNWLVFGAGPHDCLARRYVPLSMAGMIGKAALELDWVHHPTERSEEIRVFATLFPMDGCQLVFSK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the sesterterpenes ophiobolins, fungal phytotoxins with potential anti-cancer activities (PubMed:27116000).  The first step of the pathway is performed by the sesterterpene synthase oblA that possesses both prenyl transferase and terpene cyclase activity, converting isopentenyl diphosphate and dimethylallyl diphosphate into geranylfarnesyl diphosphate (GFPP) and further converting GFPP into ophiobolin F, respectively (By similarity).  Other sesterterpenoids (C(25) terpenoids) are found as minor products of oblA (By similarity).  The cytochrome P450 monooxygenase oblB then catalyzes a four-step oxidative transformation of ophiobolin F to yield ophiobolin C (PubMed:27116000).  The function of the cytochrome P450 monooxygenase oblE has still to be determined (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase oblE, Ophiobolin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GCSP_NITWN
Sequence: MIAREEPATTFARRHIGPSSRDIAAMLETVGAKSLEALMNEALPPSIRQKTPLDLGEGFSETEVLTHMQALAAQNQPLTSLIGQGYSGTILPAVIQRNILENPAWYTAYTPYQPEISQGRLEALFNFQTMICDLTGLDVANASLLDEATAAAEAMALAERASSVKTKAFFVDHEVHPQTLAVLRTRAEPLGWTLVTGDPLHDLDKADVFGAVLQYPGTSGVVRDLRPAIAAIKAKGGLAVVAADLLALTLLTSPGVLGADIAIGSAQRFGVPMGYGGPHAAYMAVCNALKRLLPGRLVGLSVDSRGTPAYRLALQTREQHIRREKATSNICTAQVLLAVISSMYAVYHGPEGLAQIARTVHRHTATLAAGLTRLGFAPLNSTAFDTLTVNAGERQSEIVKRASSQGINLRINADGTLGIALDELTIEETVEALWRAFGATWSYADVEAHAPDLLPADLKRKTAYLTHPVFHEHRSETELLRYMRKLSDRDLALDRAMIPLGSCTMKLNATTEMIPLTWAAFANLHPFAPPEQAEGYFTLFENFEEWLLDITGYDAISLQPNSGAQGEYAGLLAIRGYHAARGESHRTVCLIPSSAHGTNPASANMAGMDVVVVACDARGDVDVDDLRTKSTQHADRLAAIMITYPSTHGVFEERIREICDIVHGHGGQVYLDGANMNAQVGLSRPGDYGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFLPGHPAIDDATPSAVGPVSAAPFGSASILTISYIYILMMGSEGLKRATEVAILNANYIAQRLDPHFPVLYRNVKGRVAHECIIDPRALKAKTGVTVDDIAKRLIDYGFHAPTMSFPVPGTLMIEPTESESKAELDRFCDAMIAIRQEIAEIEAGRWKVEASPLRHAPHTAHDIADDAWSRPYSRAQGCFPSGSSRSDKYWCPVGRVDNAYGDRNLVCSCPPVEDYAQAAE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: PSF1_YEAST
Sequence: MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQLGMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDTNNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGVFNLIKDSQFFVRQSDVERLIQQGYLQKI
What is the function of this protein?
Required for DNA replication.  Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery.  Required for the chromatin binding of CDC45.
What are the official names of this protein?
DNA replication complex GINS protein PSF1, Partner of Sld five 1.
What is the protein family that this protein belongs to?
Belongs to the GINS1/PSF1 family.
Protein: ABCD1_DANRE
Sequence: MSVYSKLPSQLKKPLVKKAVVLLIALYGVKKLSPYFFGKLKGRTSKQVKGADPLTSNGEPLVEAARKRKRSPAVNREFFDRLIRLLKILFPRLFCKELGLLGFHSLALISRTFLSIYVANLDGQIVKTIVKKDPRAFVVELTKWLLIAIPATFVNSAIRYLEGQLTLAFRTRLVTHAYMLYFSDQTYYRVSNMDGRLANPDQSLTEDVVMFAASVAHLYSNLTKPILDVVVTCYTLIKTAESKGANTTWPSVIAGIVVALTAKVLRAFSPRFGKLVAEEARRKGDLRYMHSRIIANSEEIAFYGGHKIEMLQLQRSYNSLSRQINLILFKRLWYVMLEQFLMKYLWSASGLVMVAVPIITATGYSKYDSEDVKQAALDMKEEDLVSERTQAFTTARSLLNAAADAVERIMVSYKEVTELAGYTARVYEMFEVFEDVRDGVYRRSATEVKPEETGAPQNVTHGMRVEGPLQIRGQVIDVEQGIKCENLPIITPTGDVVVSSLNMQVDEGMHLLITGPNGCGKSSLFRILSGLWPVYSGVLYKPSPDHMFYIPQRPYMSVGTLRDQVIYPHSVQEMQEKGITDRQLEEILQTVSLRYILEREGGWDAVSDWKDVLSGGEKQRMGMARMFYHKPQYALLDECTSAVSIDVEGKIFEAAKDAGISLLSITHRPSLWKYHSHLLQFDGEGGWRFEKLDASTRISLQDEKIRLETQLSGIPKMQQRLTELCRILGEDSSLPTPGDEEEDEEEDEKQTERDVQSAGKEKDLME
What is the function of this protein?
ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen.  Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process.  Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (By similarity).  Involved in oligodendrocyte patterning and myelination (PubMed:28911205).
What are the official names of this protein?
ATP-binding cassette sub-family D member 1, Adrenoleukodystrophy protein, ALDP.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: FLZ12_ARATH
Sequence: MLSSNPMTWKLSHMVVPGKNSTISPDYFTASQTSPLDMMKFPSPGSSKRYDNGGGIGLGIVAALEKSSIGINPVCHTGAGSKGFDLARYSKRFQFAAGIDLSDSEEYTCVTTRDGLTKVYYKEEEFEFGHNLLNGDQRWRKPIEIAEESPAKERRVLRDCPDFLTSCCLCKKKLQGKDIYMYKGDEGFCSKECRSLKIMEDSLKEQHKLTSVEVLTGEEIASPGIFLI
What is the function of this protein?
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
What are the official names of this protein?
FCS-Like Zinc finger 12.
What is the protein family that this protein belongs to?
Belongs to the FLZ family.