PharMolix/UniProtQA huggingface dataset:
Protein: URE1_BURM1
Sequence: MTLRLSRRAYAEMFGPTTGDRVRLADTDLLIEIERDFTIYGEEVKFGGGKVIRDGMGQSQRVAAEVPDTVITNAVILDHWGIVKADIAIKHGRIAAIGKAGNPDIQPGVTIPIGAGTEVIAGEGLIVTAGGIDTHIHFISPQQIDEALASGVTTMLGGGTGPATGTNATTCTPGPWHMERMLQAADGWPINLGFLGKGNASRPEPLLEQIAAGAIGLKLHEDWGTTPAAIDTCLSIADDTDTQVAIHTDTLNEAGFVESTVAAFKGRTIHTYHTEGAGGGHAPDILKVCGEANVLPSSTNPTRPYTINTLEEHLDMLMVCHHLDPSIAEDLAFAESRIRRETIAAEDILHDLGALSMLSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALPEDSARNDNFRAKRYVAKYTINPAITHGIAHQVGSIEPGKWADLVLWEPAFFGIKPTMILKGGMIALAQMGDPNASIPTPQPVHYREMFATRGGALARTSLTFVSQLAADAGIAERYGLAKPIVPVRNCRQVTKADMIHNAWRPAISVDPETYDVIADGQLLTCEPASVLPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHMP7_PONAB
Sequence: MWSPEREAEAPAGGDPAGLLPPEWEEDEERMSFLFSAFKRSREVNSTDWDSKMGFWAPLVLSHSRRQGVVRLRLRDLQEAFQRKGSVPLGLATVLQDLLRRGELQRESDFMASVDSSWISWGVGVFLLKPLKWTLSNMLGDNKVPAEEVLVAVELLKEKAEEVYRLYQSSPLSSHPVVALSELSTLCANSCPDERTFYLVLLQLQKEKRVTVLEQNGEKIVKFARGPHAKVSPVNDVDVGVYQLMQSEQLLSRKVESLSQEAERCKEEARRACRAGKKQLALRSLKAKQRTEKRIEALHAKLDTVQGILDRIYASQTDQMVFNAYQAGVGALKLSMKDVTVEKAESLVDQIQELCDTQDEVSQTLAGGVTNGLDFDSEELEKELDILLQDTTKEPLDLPDNPRDRHFTNSVPNPRISDAGLEAELEKLSLSEGGLVPSGKSPKRQLEPTLKPL
What is the function of this protein?
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (By similarity).  Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (By similarity).  Recruited to the reforming NE during anaphase by LEMD2 (By similarity).  Plays a role in the endosomal sorting pathway (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 7, Chromatin-modifying protein 7.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area. Localizes to the reforming nuclear envelope on chromatin disks during late anaphase.
Protein: CTB5_CERBT
Sequence: MLGLNLQQVLSNVPTISSIVSGVGSYQHGSDSSAWASVAASKSCCDALTKSLGKNSVVFPYDAAYSQSMGSYFSLKNSDLHPSCIALPRSAEDVSKAVRTLSLGAHKWEGQCQFGVRGGGHTPFKGAASTDNGIVLDLLHMPSAGISPDYETITVSPSTTWDLVYEVLDAHNRSTLGTKVAGIGVGGASTSCGVSYFSPRYGYICDMVENWEVVLATGDIVNANANENPDLWKALRGGINNFGIVTAVTLKTFGQGPFWGGQTFHSIDTRQEHFKNHEKLASAHPYDPYAHYINTLVWANGGHWFIGNSIQYTKSDPPVAEPEVFKPFLKTERTPIFPGLPEDTLRVDNVTSFSREYAANTLYPQRWQFACISFAPDADFMETFFQMANDAMQQYVKLAGFKLILNYQPAPTVQLERNGAVDSLGPIQTEGNVVFVHWAVSYDESEAQFDDAITKSVQDLFHAANAKAKELGIYRHFIQPTYADSWQSPFDYRSKSTIEELVATSKKYDPLQVFQKQVPGGFKLPQI
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin (By similarity).  The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules (PubMed:11701851).  These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids (PubMed:11701851).  The first step of cercosporin biosynthesis is performed by the polyketide synthase CTB1 which catalyzes the formation of nor-toralactone (By similarity).  The starter unit acyltransferase (SAT) domain of CTB1 initiates polyketide extension by the selective utilization of acetyl-CoA, which is elongated to the heptaketide in the beta-ketoacyl synthase (KS) domain by successive condensations with six malonyl units introduced by the malonyl acyltransferase (MAT) domain.  The product template (PT) domain catalyzes C4-C9 and C2-C11 aldol cyclizations and dehydrations to a trihydroxynaphthalene, which is thought to be delivered to the thioesterase (TE) domain for product release (By similarity).  The bifunctional enzyme CTB3 then methylates nor-toralactone to toralactone before conducting an unusual oxidative aromatic ring opening (By similarity).  The O-methyltransferase CTB2 further methylates the nascent OH-6 of the CBT3 product, blocking further oxidation at this site before the reductase CTB6 reduces the 2-oxopropyl ketone at position C7, giving naphthalene (By similarity).  The FAD-dependent monooxygenase CTB5 in concert with the multicopper oxidase CTB12 are responsible for homodimerization of naphthalene with CTB7 installing the dioxepine moiety, finally producing cercosporin (By similarity).  The fasciclin domain-containing protein CTB11 might act with CTB5 and CTB12 whereas the roles of CTB9 and CTB10 have still to be elucidated (By similarity).
What are the official names of this protein?
FAD-dependent monooxygenase CTB5, Cercosporin toxin biosynthesis cluster protein 5.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: CH088_HUMAN
Sequence: METKKLIGKPLQPARPVRHLTSPPGAVFPFNFQNEYPCNTQCIQSGVSRCKTNGMQAFSQGLNEQQQQQSPVKKERIKYSRDFLLKLSSVSICRKKPDFLPDHPIVLQKPENNQSFK
What are the official names of this protein?
Uncharacterized protein C8orf88.
Protein: NFI_ECOL6
Sequence: MDLASLRAQQIELASSVIREDRLDKDPPDLIAGADVGFEQGGEVTRAAMVLLKYPSLELVEYKVARIATTMPYIPGFLSFREYPALLAAWEMLSQKPDLVFVDGHGISHPRRLGVASHFGLLVDVPTIGVAKKRLCGKFEPLSSEPGALAPLMDKGEQLAWVWRSKARCNPLFIATGHRVSVDSALAWVQRCMKGYRLPEPTRWADAVASERPAFVRYTANQP
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_ECOL6
Sequence: MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRAEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVSVCRKHYKEALEVGSLTAIQERHRHD
What is the function of this protein?
Phosphorylates both thymidine and deoxyuridine.
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPF_ECO45
Sequence: MQFSKMHGLGNDFMVVDAVTQNVFFSPELIRRLADRHLGVGFDQLLVVEPPYDPELDFHYRIFNADGSEVAQCGNGARCFARFVRLKGLTNKRDIRVSTANGRMVLTVTDDDLVRVNMGEPNFEPSAVPFRANKAEKTYIMRAAEQTILCGVVSMGNPHCVIQVDDVDTAAVETLGPVLESHERFPERANIGFMQVVKREHIRLRVYERGAGETQACGSGACAAVAVGIQQGLLAEEVRVELPGGRLDIAWKGPGHPLYMTGPAVHVYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIPA_ECOLI
Sequence: MTKLKLLALGVLIATSAGVAHAEGKFSLGAGVGVVEHPYKDYDTDVYPVPVINYEGDNFWFRGLGGGYYLWNDATDKLSITAYWSPLYFKAKDSGDHQMRHLDDRKSTMMAGLSYAHFTQYGYLRTTLAGDTLDNSNGIVWDMAWLYRYTNGGLTVTPGIGVQWNSENQNEYYYGVSRKESARSGLRGYNPNDSWSPYLELSASYNFLGDWSVYGTARYTRLSDEVTDSPMVDKSWTGLISTGITYKF
What is the function of this protein?
May serve as a scaffold protein required for the formation of a complex with MrcB/PonB and MltA, this complex could play a role in enlargement and septation of the murein sacculus.
What are the official names of this protein?
MltA-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the MipA/OmpV family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: NDST2_HUMAN
Sequence: MLQLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSGGAAGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPGRGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLLASLRPAEPAVPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFESLVRFLQCWTRLRLQTLPPVPLAQKYFELFPQERSPLWQNPCDDKRHKDIWSKEKTCDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNSPNYHKGIDWYMDFFPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAHGDPVALNYTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWCQGLEGGKTRCLGRSKGRRYPDMDTESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREELQHSSLG
What is the function of this protein?
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate.  Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.  Plays a role in determining the extent and pattern of sulfation of heparan sulfate.  Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
What are the official names of this protein?
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2, Glucosaminyl N-deacetylase/N-sulfotransferase 2, NDST-2, N-heparan sulfate sulfotransferase 2, N-HSST 2.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family. NDST subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: WAPP_COCIM
Sequence: MASPVTVLENPIPKSGQHLLFFLTSKQQLALEQRPIESSLGYSAYVDHGVSQGVIVNPSSIAAAMRSSLVTVYGITKPGTDKQYISVISPTYNLIANRQNQPIETTQKALAACSDNDRNNWVYYLNLPQGTPQYAIYELNIQDSSSAPTVYSGPTPSGNSNLAAVYFSPNKDRFIIFSNTDTRHYLYWVNSTLQSANRISGTGSVMSASPLAATTITNVQTRSMTIFLYYMDVNTLLNRIVGKVTDNEIHWYANQVVEGAPPMKVDTLLTGVVVEGKWNCLYYIPDGDTEFRAFNDTIRDSFFDEPREG
What is the function of this protein?
May participate in wall plasticization and/or intussusception or in cell wall turnover.
What are the official names of this protein?
Wall-associated proteinase.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: IDI2_STRPM
Sequence: MTNRKDDHIKYALKYQSPYNAFDDIELIHHSLPSYDLSDIDLSTHFAGQDFDFPFYINAMTGGSQKGKAVNEKLAKVAAATGIVMVTGSYSAALKNPNDDSYRLHEVADNLKLATNIGLDKPVALGQQTVQEMQPLFLQVHVNVMQELLMPEGERVFHTWKKHLAEYASQIPVPVILKEVGFGMDVNSIKLAHDLGIQTFDISGRGGTSFAYIENQRGGDRSYLNDWGQTTVQCLLNAQGLMDQVEILASGGVRHPLDMIKCFVLGARAVGLSRTVLELVEKYPTERVIAIVNGWKEELKIIMCALDCKTIKELKGVDYLLYGRLQQVN
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3206_YERPG
Sequence: MKLGLVAGMLAVCFSFSSVAMTLKLTPEIDLLVVDGKNMSGSLLKGADSLELNSGMHQILFKVIKTLPTDPLVLYSSPPLIVVFNAHNTRSVAIKLPVINTLRDGHQFSKNPLYQLIGDNGHPLSVRHDVLRQDHLNNSTTLETVMAAYNVGKYNASVPAFAAIPPSPVSAVPGTTIPVAGVNTPHKTASLQGENVTEQMLQYWFLQANPETQKRFLIWAKKQPIH
What are the official names of this protein?
UPF0319 protein YpAngola_A3206.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: SYV_PSESM
Sequence: MDKTYQPHAIETSWYQTWESENYFAPQGAGDSYTIMIPPPNVTGSLHMGHGFNNAIMDALIRFRRMQGRNTLWQPGTDHAGIATQMLVERRLEAQGVSRHELGREKFLDKIWEWKAESGGNISRQIRRLGSSVDWSRERFTMDDGLSDAVKEAFVRLHEDGLIYRGKRLVNWDTKLHTAISDLEVENHDEKGHLWNLRYPLADGAKTAEGLDYLIVATTRPETMLGDAAVAVNPQDERYKALIGKFVELPLVGRRIPIIADDYCDPEFGTGCVKITPAHDFNDYEVGKRHNLPLLNIFDKNANVLPAAQVFNLDGKLNESVDGTLPAAYAGLDRFEARKQIVAAFDAAGLLVSIDDHALKVPKGDRSGTIIEPWLTDQWYVSTKPLAEPAIAAVEDGRIAFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDESGKVYVGRDEAEVRAKNNLGPEIALQQDNDVLDTWFSSGLWTFSTLGWPEKTKALETFHSTDVLVTGFDIIFFWVARMIMLTLHLVKNEDGTPQVPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGIDLETLVEKRTSGLMQPQLAKKIEKQTRQEFADGIASYGTDALRFTFCSLASTGRDIKFDMGRVEGYRNFCNKIWNAARYVLDKGEDCGQNGEAVELSLADRWIISQLQRTEAEVTRQLDQFRFDLAAQALYEFIWNQYCDWYLELSKPVLWDETASIERQRGTRRTLVRVLEVALRLAHPFMPFITEEIWQRLAPLAGVEGKTIMLQPWPVANEARIDQAAEDDIEWLKGLMLAVRNIRGEMNIGPGKPLQLFLKNVSADDQRRLSENDYLLRKLAKLESMTVLTDGAEAPLSATALVGDMEVLVPMAGLIDKGAELARLDKEIQRLQGEVQRVGGKLSNAAFVDKAPPDVIAKERAKLTEAEQALGKLAEQHARIASL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBKTP_CUPNH
Sequence: MKATGTFFFVVGPSGAGKDSLIDGARAALDGDYVFARRVITRPDGSAGEEHEGVTEAEFARRQRSGEFLVTWDAHDLRYGLPKSLMCELERGRNVVANGSRGVIAELAARLPRFVVVLVTAPHDVLARRIAARGRESGDQVASRVARAGAPVPPHVPCITVSNHSTLEAGTARFVEALRTGTRTSAAERPASRTNLMAKLRGEPLDEAAYVAVLQDAIAGRYTEAELTEFLVAATRTLTDEEVVALARARTAFTPRIDWDEPVVVDKHSMGGVPGSRITLIVVPIVAAYGLAMPKTSSRAITSAAGTADAMETIARVDLAHEDVRRCVAQARACIAWNGRLNHSVVDDVMNAITRPLRLDSRRWSVASILSKKYTAGATHVIVDLPYGPQTKLATRADAEALGALFEHVGKGLGLHVRALVTDGSGPIGRGIGPALEVRDVRLVLDNAPDAPADLRDKALRFAGEIIAFDPRVDSPEHGMQIAAALLHEGKARAAFDRIAAAQGVRCDPVAPGTHTLVVPATTRGRVAGVDGLQISGVARAAGAPRDGGAGVDMLCAIGAKVAPGQPLYRIHSDSAEALEAAAALVRAGGECCQAVRIDPD
What is the function of this protein?
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
What are the official names of this protein?
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Protein: TRMD_YERPB
Sequence: MWIGVISLFPEMFRAITDYGVTGRAVKNGLLSVQCWSPRDFTYDRHRTVDDRPYGGGPGMLMMVQPLREAIHAAKAAAGEGAKVIYLSPQGRKLDQQGVCELAMNQKMILVCGRYEGVDERVIKTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHHASAEEDSFVDGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLESLALTDEQMVLLAEFQREHKP
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5802_PSEF5
Sequence: MLKKTLAALAIGSAVLAAGQVMAADYVIDKEGQHAFVDFKISHLGYSFITGTFKDLDGKFSFDAAKPEDAKIEVNVRTASVFTNHAERDKHITSKDFLDAGKFADAKFVSTSVKPTGKNADGKLTADVAGDLTLHGVTKPVVVKATFLGEGKDPWGGYRAGFEGTTSINRQDFGKMMDLGPASNNVDLYISFEGVKAK
What are the official names of this protein?
UPF0312 protein PFL_5802.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: DNAI7_MACFA
Sequence: MGPKAKKSGSKKKKVTKAERLKLLQEEEDRRLKEEEEARLKYEKEEMERLEIQRIEKEKWNRLEAKDLERRNEELEELYLLERCFPEAEKLKQETRMLSQWKHYIQCDGSPDPSIAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPLCDLQDKNIIQYQESILQLQELLHLKFNVATEILLRQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEHTSSATELVKDDVENVEKAISKEVEEESKQQEKQSHLIQEEKLKVEEEQDDIEVKMGSAEEESEAIKCELEMKVLSETVSAAQLLLVENSSEKPDFFENDMVDLFQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPETTEDFETENAFPPIEVTLEVHENVIFFENPMVVRWDAEGKHWRTDGISNVSYKPNERLITFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSVKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRYSHFYVVINNKVPLVEVKAYRQMALLSSTFAFGWSKWNLLCNSTKVVFKVREHLPEECTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVRDFASKEAMEKVRSSNCQFVNSVCHMLLSTRLLSYS
What is the function of this protein?
Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function.  May act as a cell cycle regulator.
What are the official names of this protein?
Dynein axonemal intermediate chain 7.
What is the protein family that this protein belongs to?
Belongs to the DNAI7 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm. Note=Colocalizes with microtubules in interphase.
Protein: GAUT5_ARATH
Sequence: MNQVRRWQRILILSLLLLSVLAPIVFVSNRLKSITSVDRGEFIEELSDITDKTEDELRLTAIEQDEEGLKEPKRILQDRDFNSVVLSNSSDKSNDTVQSNEGDQKNFLSEVDKGNNHKPKEEQAVSQKTTVSSNAEVKISARDIQLNHKTEFRPPSSKSEKNTRVQLERATDERVKEIRDKIIQAKAYLNLALPGNNSQIVKELRVRTKELERATGDTTKDKYLPKSSPNRLKAMEVALYKVSRAFHNCPAIATKLQAMTYKTEEQARAQKKQAAYLMQLAARTTPKGLHCLSMRLTTEYFTLDHEKRQLLQQSYNDPDLYHYVVFSDNVLASSVVVNSTISSSKEPDKIVFHVVTDSLNYPAISMWFLLNPSGRASIQILNIDEMNVLPLYHAELLMKQNSSDPRIISALNHARFYLPDIFPGLNKIVLFDHDVVVQRDLTRLWSLDMTGKVVGAVETCLEGDPSYRSMDSFINFSDAWVSQKFDPKACTWAFGMNLFDLEEWRRQELTSVYLKYFDLGVKGHLWKAGGLPVGWLTFFGQTFPLEKRWNVGGLGHESGLRASDIEQAAVIHYDGIMKPWLDIGIDKYKRYWNIHVPYHHPHLQRCNIHD
What is the function of this protein?
May be involved in pectin and/or xylans biosynthesis in cell walls.
What are the official names of this protein?
Probable galacturonosyltransferase 5, Like glycosyl transferase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: SPP1_SCHPO
Sequence: MELTQENTEENEKTHVESIVKFEDSNRGTITDFHIETANNEEEKDANVILNKSVKMEVEEVNGHVDSSSTETDIEMQVIQQPTIPKKPPVSAHRRGPRKHRGNANSQLNLSTADHQRPLYCICQKPDDGSWMLGCDGCEDWFHGTCVNIPESYNDLTVQYFCPKCTEEGKGITTWKRKCRLRECSNPTRPNSNYCSDKHGVDFFREKVKLSTVEPSAIKNLVLFAKKREEFQNLGTVGPTLPSQVPPEVVYNFEIEEANRLNAEIVQLNKEKEVASNKKIFLQLIKDSSRRAVLAYKEREGIKKDLCGFDSRLLFNQQQMNELWEKVSNGAPLSLDMSIDPSPESTCFTEKRRCAKHTSWQVIFTEDFELQESNILQKLNMKQTAKDVMLEHQKQRCLPGIQYDGYARFCHEQLSPEKMANLLK
What is the function of this protein?
The Set1 complex specifically methylates 'Lys-4' of histone H3.
What are the official names of this protein?
Set1 complex component spp1, Set1C component spp1, COMPASS component spp1, Complex proteins associated with set1 protein spp1.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPE_THEYD
Sequence: MLTCKAFAKINWAISVLKKRDDGYHDIISLMQAIDLHDTLIFKSSQKIEIETDLLIKKENNLVYKAIKALQNYTGIKKGVTVILKKEIPLGAGLGGGSSDAATTLKALNELWQLNLDIKTLHEIGASIGSDIPFFFYLPICIVEGRGDVVKPLKISKSYTLLLVKPDFSISTEWAYKTLDLKTELTTEYEKINNNIWQLYNHLYSGDVDNFYLWNDLEKSVLEKYPEIDKIKRKLIEAGAKSSLLSGSGSTVFGLFNNKTDAQKALKFFEGYWCRVVQTLVEPLK
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: TOF1_NEOFI
Sequence: MDEEGAPLSESVQVVDPDVRAHVYSLVTALGGFNGESADRYVLGDDALACLRDIKRWLKLYDEKNNRMDVARCLGEANLVNGDLLPILTLWSTSGQKSKHMSRIALACLELLVPLTWPLEVPSKMTVNHHRHTPYLQQAQVLYKRGILSHGSDSILRTIIRIGLPSMAVPRSERTTRDEGILKLMLYFLRNIAVISPNARLAAEGDEEETSRSATINAFQNQDAFALLLTMCSNVGEDFSLQDVVLLEILFHIVKGVNVEKLFMNDAQRKAKRTDELGELLQKESSLRREYAKNAPTRHGRFGTMIWVKRDDAKVSTVSGQDVLKDSQTTLHKMDQSKKWNKPQIRRRAAEVTANNDFNTPVNLNSTATKNLRMFVEEFLDSGFNPLFTHVRKAIEREADRVLDINTRQFFYTVAWFLEAERVRRAHQREKRHLGDKSLNEIEPDSFALVASVLNQETFVFLNRSMQYSYDNKDVEDLTAEMRCFTQILLTVQEMAQSPLEEDQEIADNIQNRIFYEETTHDRIIAIVRGYKDQGFGYLDACTELAHVFLKMLEHYSKENVDMHIRSRRRAKRKAKQAKQADIEGDDEEQASEEEDLMDAERISKERKFDFKRFAAKFCNQSCVDTFIAFTKYYKELNVDQLKRAHRYFYRIAFKQEMSVLLFRLDIINLFYRMIKGPGALDSNKPIFKEWEELVRQIIRRMVKKIDQRPALITELLFSKINSTVFYLEYGHEKQTISASKRPPAELEVDPREAKTTDEKIKIVVHVMVKDEHTDLVKWVSDVLNSAADEREAWESQEQHSEGQKAPNPMIPVKSNNESCQKAMFSNAKLRLLMTLVRFERLGMEDVPGASWIVPSSLTSQDLRHTRSMIEQCLTEPVTESSDRDLSQLIRRKSGNNTRRDRDDQTADVDFGSDSEGDDNVPDGPLFPPNPRSRASALEQLKKQRKKRRKQAGEEEEPDEEDLEGRRRARLENALARQAKIKSDLYIHASDEQTDEEADQEFFRLEEQRRKEQAERIRKALLHGVVEEASENSRKKGSGRKRQSDQHTASTADSQSKRQRRQQRTGGLDDDDDLVMTGTDARSPDSLGQGSPSLQGANDVEDTPVTSEENELDFDDDLAFSRNRNRDKVLSAENDDSDTEPPAPDTIDEDDDDEAAPVAAPPRRRMRAGFVIESDSE
What is the function of this protein?
Forms a fork protection complex (FPC) with csm3 and which is required for chromosome segregation during meiosis and DNA damage repair.  FPC coordinates leading and lagging strand synthesis and moves with the replication fork.  FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
What are the official names of this protein?
Topoisomerase 1-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the timeless family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL5_GEOSW
Sequence: MNRLKEKYLKEVTPALMSKFNYKSIMQVPKIEKIVINMGVGDAVQNPKALDSAVEELTLIAGQKPVVTRAKKSIAGFRLRAGMPIGAKVTLRGERMYDFLDKLISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVNKVRGMDIVIVTTAKTDEEARELLTLLGMPFQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: YYAP1_HUMAN
Sequence: MEEEASRSAAATNPGSRLTRWPPPDKREGSAVDPGKRRSLAATPSSSLPCTLIALGLRHEKEANELMEDLFETFQDEMGFSNMEDDGPEEEERVAEPQANFNTPQALRFEELLANLLNEQHQIAKELFEQLKMKKPSAKQQKEVEKVKPQCKEVHQTLILDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLNPEASSTRICLKELGTFAQSSIALHHQYNPKFQTLFQPCNLMGAMQLIEDFSTHVSIDCSPHKTVKKTANEFPCLPKQVAWILATSKVFMYPELLPVCSLKAKNPQDKILFTKAEDNKYLLTCKTARQLTVRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEIQPHQWKPPIEREEHRLPFWLKASLPSIQEELRHMADGAREVGNMTGTTEINSDQGLEKDNSELGSETRYPLLLPKGVVLKLKPVADRFPKKAWRQKRSSVLKPLLIQPSPSLQPSFNPGKTPAQSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAMPPEARTSFPLSESQTLLSSAPVPKVMMPSPASSMFRKPYVRRRPSKRRGARAFRCIKPAPVIHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQTIPIATLLVNPTSFPCPLNQPLVASSVSPLIVSGNSVNLPIPSTPEDKAHMNVDIACAVADGENAFQGLEPKLEPQELSPLSATVFPKVEHSPGPPPVDKQCQEGLSENSAYRWTVVKTEEGRQALEPLPQGIQESLNNSSPGDLEEVVKMEPEDATEEISGFL
What is the function of this protein?
Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641).  Enhances transcription activation by YY1 (PubMed:14744866).  Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641).
What are the official names of this protein?
YY1-associated protein 1, Hepatocellular carcinoma susceptibility protein, Hepatocellular carcinoma-associated protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus.