PharMolix/UniProtQA huggingface dataset:
Protein: M1_I60A0
Sequence: MSLLTEVETYVLSIIPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVVLGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRVIGTHPSSSAGLKNDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: ATPD_CROS5
Sequence: MKGSLFSTEIAEPYAQALMSLAQSRDITRSIGEDCRSILDILEESAELREFISSPIIKDEDKRGVLNRLLGNDIHHYLRNFLMLLVDKRRIVFLQAICEQYLALLRKLTNTVLAEVTASTELSEGQRRDVIDKIKALTGAESVELKTDIDPDLIGGVIIKVGSQVFDASLRGQLRRISISLTGAS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: PPAC_STRS7
Sequence: MSKILVFGHQNPDTDAIASSYAFDYLAKKAFDLDTEVVALGDPNEETAFALDYFGVSAPRVVTSAKAEGASHVILTDHNEFPQSISDIREVEVYGIVDHHRVANFETANPLYMRVEPVGSASSIVYRLFKENRVDVPKDIAGLLLSGLISDTLLLKSPTTHASDHRVAVELAELAGVKLEEYGMAMLKAGTNLASKSEAELIDIDAKTFELNGNAVRVAQVNTVDIAEVLERKEAIEAAIKEVMASEGYSDFVLMITDIVNSNSEILALGANMDKVEAAFSFKLEDNHAFLAGAVSRKKQVVPQLTESFGA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG1_USTMA
Sequence: MSKSSTGRDERIGDFVIENEIGKGSFAVVHKGYRLQPREPVAIKIVIRKKLTPKLLDNLEGEIAILKAIHHPNIVELKECLKTEHQIYLVMAFCASGDLAQYIKKRFDIYERAGMAEPDSLTKGFKPTYPHPVDGGLNETIVRSILTQLAAALEFMRARDIVHRDIKPQNLLLQPPDAAFLALGNPREIPQMKVADFGFARHLSVNTLAETLCGSPLYMAPEILRFEKYDAKADLWSVGAVLFEMTVGKPPFRAANHVELLKRIERGEDKIKFPDERSAGSLAREAARRQELGEAPLPPPHPVSEDVKILIRQLLRQRPVSRMSFDDFFASPVISDFKAFIRPRAQPEAVERYEDLQRSERSVIIPSSGIKHVSVSSIEASTQQPGVQPPVSTATSPPALESRSTQEASPKAITGETIAPNKTPREDARPPRTLPRAFSAKYVTGEPPQPEDLEKRVPPTMTRTPSSPGIPEGSLLSGERDEAPQATTEHFGSSKGGEDSFLGKEYVLIEKQSVEVNALADELAASPQSRLGLASRRPSRLSRLSSGPLPSAPGASPPTAPPTILSSKPIRIANNTNTASTGAFALPPGSRPSSFPRRASLSSSGSPSTRQGGQVITNMDAVASTQSNRRDGNASSFPKDEVSVLGQRLAGFGLSGSGVGGGPSSALAKAISMASLRLFGVPSGVSLRDAAALVRTRAQRRGIARATDSLDEAEMTLLSTLEDLGQKAFVLSEFADSKLAHFFPDGPHQLSQELDSSTATSGISPSRNSVQGSARRVGSISSSSSSAVDPVAAEAASAEALMLYVRSLAFLQRAITLTKRHVESRSRPGVPAVTSAELNDVVQWLRARFNEVYDKADFARSRCSELPESAQQVDKLIFDKAVEVARAAATDELENNREGSGWDPSHCLLAYETANSMLSSLLDPGEDAMSLSEGSILMIDGYVKSINKRLWTLQEQFGGGVGAVGAAGASPVGVDAEARPGVSRSRTESP
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (By similarity).  Required for wild-type budding of haploid sporidia and for complete symptom development during pathogenic growth such as gall formation and teliospore production in ears of mature maize (PubMed:20618705).
What are the official names of this protein?
Serine/threonine-protein kinase ATG1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: SYW2_STRAW
Sequence: MASDRPRVLSGIQPTAGSFHLGNYLGAVRQWVALQESHDAFYMVVDLHAITVPQDPADLRANTRLAAAQLLAAGLDPERCTLFVQSHVPEHAQLAWIMNCLTGFGEASRMTQFKDKSAKQGADRASVGLFTYPVLQVADILLYQANEVPVGEDQRQHIELTRDLAERFNGRFGETFTVPKPYILKETAKIFDLQDPSIKMSKSASTPKGLINLLDEPKATAKKVKSAVTDTDTVIRYDAEHKPGISNLLTIYSTLTGTGIPELEEKYTGKGYGALKTDLAEVMVDFVTPFRERTQQYLDDPETLDSILAKGAEKARAVAAETLSQAYDRVGFLPAKH
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase 2, Tryptophanyl-tRNA synthetase 2, TrpRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_BACC1
Sequence: MPKGSGKVIAQNKKAFHDYFIEETYEAGLVLQGTEIKSIRAGRVNLKDAFARVHNGEVWVHNMHISTYEQGNRFNHDPLRTRKLLLHKKEIDKLAGAAKETGYALVPLKIYLKNGFAKMALGLAKGKKQYDKRHDLKEKEAKREIARAFRDRQKM
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ZBED1_HUMAN
Sequence: MENKSLESSQTDLKLVAHPRAKSKVWKYFGFDTNAEGCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHPEEFCEFVKSNTEQMREAFATAFSKLKPESSQQPGQDALAVKAGHGYDSKKQQELTAAVLGLICEGLYPASIVDEPTFKVLLKTADPRYELPSRKYISTKAIPEKYGAVREVILKELAEATWCGISTDMWRSENQNRAYVTLAAHFLGLGAPNCLSMGSRCLKTFEVPEENTAETITRVLYEVFIEWGISAKVFGATTNYGKDIVKACSLLDVAVHMPCLGHTFNAGIQQAFQLPKLGALLSRCRKLVEYFQQSAVAMYMLYEKQKQQNVAHCMLVSNRVSWWGSTLAMLQRLKEQQFVIAGVLVEDSNNHHLMLEASEWATIEGLVELLQPFKQVAEMLSASRYPTISMVKPLLHMLLNTTLNIKETDSKELSMAKEVIAKELSKTYQETPEIDMFLNVATFLDPRYKRLPFLSAFERQQVENRVVEEAKGLLDKVKDGGYRPAEDKIFPVPEEPPVKKLMRTSTPPPASVINNMLAEIFCQTGGVEDQEEWHAQVVEELSNFKSQKVLGLNEDPLKWWSDRLALFPLLPKVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLYENARSGAEAEPEDQDEGEWGLDQEQVFSLGDGVSGGFFGIRDSSFL
What is the function of this protein?
(Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
What are the official names of this protein?
E3 SUMO-protein ligase ZBED1, DNA replication-related element-binding factor, Putative Ac-like transposable element, Zinc finger BED domain-containing protein 1, dREF homolog.
What are the subcellular locations of this protein?
Nucleus, PML body. Nucleus. Note=In granular structures. SUBCELLULAR LOCATION: Nucleus, PML body. Note=(Microbial infection) Upon interaction with human adenovirus early E1A protein, the protein is redistributed to the peripheral areas of PML bodies.
Protein: PULA_KLEPN
Sequence: MLRYTRNALVLGSLVLLSGCDNGSSSSSSGNPDTPDNQDVVVRLPDVAVPGEAVTAVENQAVIHLVDIAGITSSSAADYSSKNLYLWNNETCDALSAPVADWNDVSTTPSGSDKYGPYWVIPLNKESGCINVIVRDGTDKLIDSDLRVAFGDFTDRTVSVIAGNSAVYDSRADAFRAAFGVALAEAHWVDKNTLLWPGGQDKPIVRLYYSHSSKVAADGEGKFTDRYLKLTPTTVSQQVSMRFPHLSSYAAFKLPDNANVDELLQGETVAIAAAEDGILISATQVQTAGVLDDAYAEAAEALSYGAQLADGGVTFRVWAPTAQQVDVVVYSADKKVIGSHPMTRDSASGAWSWQGGSDLKGAFYRYAMTVYHPQSRKVEQYEVTDPYAHSLSTNSEYSQVVDLNDSALKPDGWDNLTMPHAQKTKADLAKMTIHESHIRDLSAWDQTVPAELRGKYLALTAGDSNMVQHLKTLSASGVTHVELLPVFDLATVNEFSDKVADIQQPFSRLCEVNSAVKSSEFAGYCDSGSTVEEVLNQLKQSDSQDNPQVQALNTLVAQTDSYNWGYDPFHYTVPEGSYATDPEGTTRIKEFRTMIQAIKQDLGMNVIMDVVYNHTNAAGPTDRTSVLDKIVPWYYQRLNETTGSVESATCCSDSAPEHRMFAKLIADSLAVWTTDYKIDGFRFDLMGYHPKAQILSAWERIKALNPDIYFFGEGWDSNQSDRFEIASQINLKGTGIGTFSDRLRDSVRGGGPFDSGDALRQNQGIGSGAGVLPNELASLSDDQVRHLADLTRLGMAGNLADFVMIDKDGAAKKGSEIDYNGAPGGYAADPTEVVNYVSKHDNQTLWDMISYKASQEADLATRVRMQAVSLATVMLGQGIAFDQQGSELLRSKSFTRDSYDSGDWFNRVDYSLQDNNYNVGMPRISDDGSNYEVITRVKEMVATPGEAELKQMTAFYQELTELRKSSPLFTLGDGSAVMKRVDFRNTGSDQQAGLLVMTVDDGMKAGASLDSRLDGLVVAINAAPESRTLNEFAGETLQLSAIQQTAGENSLANGVQIAADGTVTLPAWSVAVLELPQGEAQGAGLPVSSK
What are the official names of this protein?
Pullulanase, Alpha-dextrin endo-1,6-alpha-glucosidase, Pullulan 6-glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: FAL1_CRYNJ
Sequence: MAGVNVGDDKLVFESSEAVTVAPTFEALNLKEDLLRGIYAYNFEKPSAIQQRAIIPIIRGRDVIAQAQSGTGKTATFSISMLQSIDTNLRETQALVLSPTRELAVQIQTVVLALGDYMNVSCHACIGGTSVGEDIRKLEAGQQVVSGTPGRVFDMIRRRNLRTKDIKMLILDESDELLNKGFKDQIYDIYRYLPPATQVVVVSATLPHDVLEMTTKFMTDPVRILVKRDELTLEGIKQFFVAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTEKMREANFTVSSMHGEMVQKERDAIMAEFRGGQSRVLITTDVWARGIDVQQVSLVINYDLPTSRENYLHRIGRSGRFGRKGVAINFVTVDDVRILRDIEQYYSTQIDEMPMNVAELT
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase FAL1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: UAPC_EMENI
Sequence: MDGPDQIGPDVRPRRTFGDRVRRAARAFTTRDGLIGDYDYGFLFTPRLPFVKQKRRAAPFFGLEDKIPLVLALLLGLQHALAMLAGVITPPILLAGSSGANFGADESQYLVSTSLIVSGLLSAVQMFRLHVYKTRYYVGTGLVSVVGTSFATITVATGTFNQMYSTGYCPVDGSGNRLPCPKGYGALLATSCLCSLLEIGLSFMSSRLLKALFPPIVTGPTVFLIGASLIGNAMKDWAGGSGTCSSNPGNGALCPSADAPHPLPWGSAEFIGLGFLVFATIILCERFGSPIMKSCAVIVGLLVGCIVAAACGYFDRSGIDAAPVASFIWVKTFPLTIYAPLILPLLAVYMVIMMESIGDITATCDVSRLQVEGATFDSRIQGGVLGNGITCLLAGLCTITPMSVFAQNNGVIALTRCANRKAGYCCCFFLVVMGIFAKFAAALVAIPSSVLGGMTTFLFSSVAISGVRIMCSVDWTRRNRFILTASFAVGMAATLVPDWFSYFFTYSGDNHALEGLLQAVELVMANGFAVTGFLGLLLNLILPEDMEEDVVESEEDYEATTVVGMQGGSEPGSSGQNVKA
What is the function of this protein?
Able to transport with low efficiency all natural purines as well as purine analogs.
What are the official names of this protein?
Purine permease.
What is the protein family that this protein belongs to?
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GALNS_PIG
Sequence: MAAVAAATRWHLLLVLSAAGLGVTGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGMLFPSFYAANPLCSPSRAALLTGRLPIRTGFYTTNGHARNAYTPQEIVGGIPDPEHLLPELLKGAGYASKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNRARPNIPVYRDWEMVGRFYEEFPINLKTGESNLTQIYLQEALDFIKRQQATHHPFFLYWAIDATHAPVYASRAFLGTSQRGRYGDAVREIDDSVGRIVGLLRDLKIAGNTFVFFTSDNGAALVSAPKQGGSNGPFLCGKQTTFEGGMREPAIAWWPGHIPAGQVSHQLGSVMDLFTTSLSLAGLEPPSDRAIDGLDLLPAMLQGRLTERPIFYYRGNTLMAATLGQYKAHFWTWTNSWEEFRQGVDFCPGQNVSGVTTHSQEEHTKLPLIFHLGRDPGERFPLSFASTEYLDALRKITLVVQQHQESLVPGQPQLNVCNPAVMNWAPPGCEKLGKCLTPPESVPEKCSWPH
What are the official names of this protein?
N-acetylgalactosamine-6-sulfatase, Chondroitinsulfatase, Chondroitinase, Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, GalNAc6S sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Lysosome.
Protein: RL9_PAEAT
Sequence: MAKLILTHEVTGLGAAGDVVEVKDGYARNFLLPRGFALTWTKGGEKQVESIKAARAARAHASVEAAQAQAQALSSKKVKLEVKAGESGRLFGTVKPADVAAAVEAAGLGAIDKRNVELPNHIKSVGSYTANVRLHEDVSAVIDLEVVAAK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: DSC4_SCHPO
Sequence: MDTIVLDQRGEVFSFFRSLDMLCYAIIAQQYFQDPTVLLLLLKVFVQLSYLTPKPFSQLNALPLFYPLLLNFLISLMVRMFFNLPTAGESLDGYLYGGSIINFIGEKNESSRIDFITSDLVLFCLQIFMALILIASNKRPTQASHIQASQSGLSNVDGDEEPSDLITEDSRDTQQGQRQEDLQRQLENERSRLIARFSHSLYSFQHGLSFGSPQNRNTPLQRQSADSYSTPVCIEVDSEDWKDLVWKSQYATENANTNSINNSPLSSNTTGVPNSVLTNPI
What is the function of this protein?
Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions.  The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
What are the official names of this protein?
DSC E3 ubiquitin ligase complex subunit 4, Defective for SREBP cleavage protein 4.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RL27_PORGI
Sequence: MAHKKGVGSSKNGRESESKRLGVKVYGGEMAKAGNILVRQRGTVHHPGENVGIGKDHTLYALKSGVVVFTRKKNDRSYVSIKTES
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SPEB_ESCF3
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPNHSVQIGIRTEFDKDNGFTVLDACQVNDRSVDDVIAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: HVD82_HUMAN
Sequence: MKHLWFFLLLVAAPRWVLSQVQLQESGPGLVKPSETLSLTCTVSGYSISSGYYWGWIRQPPGKGLEWIGSIYHSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 4-38-2.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: ORF49_HHV8P
Sequence: MTSRRPLKDHLFNHLFRYHYPSWDQILQELDTLSVATLNPDCHVPALNVEKTLYLAKTIQILVQHRQSEPYLVPAARANLAYSLQQLYKLGNDKIRGVINGMLPLVDAGCIGFERELIKGLPRVLTLQYPHTAPLESEPPTADCTEWCLSHFVGASGRLRSEVRDILTTHNGTCAPSFQWMASVVKKFFLVETVIYEDFQDTDFNVQLNLCFFWTAVVQMYQRCIYEQKLVHIISTSLTLLKSTARSFFAWYDLYRPNLGSAALVKYTEHLIRALTPDCSDVELGELCSHLHHCKHALFSIQ
What is the function of this protein?
Plays a role in the activation the host JNK/p38 pathways necessary for KSHV reactivation from latency and for viral replication.  Induces transcriptional activation through host JUN of several ORF50-responsive promoters.
What are the official names of this protein?
Protein ORF49.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae BBRF1 family.
Protein: PDAT1_ARATH
Sequence: MPLIHRKKPTEKPSTPPSEEVVHDEDSQKKPHESSKSHHKKSNGGGKWSCIDSCCWFIGCVCVTWWFLLFLYNAMPASFPQYVTERITGPLPDPPGVKLKKEGLKAKHPVVFIPGIVTGGLELWEGKQCADGLFRKRLWGGTFGEVYKRPLCWVEHMSLDNETGLDPAGIRVRAVSGLVAADYFAPGYFVWAVLIANLAHIGYEEKNMYMAAYDWRLSFQNTEVRDQTLSRMKSNIELMVSTNGGKKAVIVPHSMGVLYFLHFMKWVEAPAPLGGGGGPDWCAKYIKAVMNIGGPFLGVPKAVAGLFSAEAKDVAVARAIAPGFLDTDIFRLQTLQHVMRMTRTWDSTMSMLPKGGDTIWGGLDWSPEKGHTCCGKKQKNNETCGEAGENGVSKKSPVNYGRMISFGKEVAEAAPSEINNIDFRGAVKGQSIPNHTCRDVWTEYHDMGIAGIKAIAEYKVYTAGEAIDLLHYVAPKMMARGAAHFSYGIADDLDDTKYQDPKYWSNPLETKLPNAPEMEIYSLYGVGIPTERAYVYKLNQSPDSCIPFQIFTSAHEEDEDSCLKAGVYNVDGDETVPVLSAGYMCAKAWRGKTRFNPSGIKTYIREYNHSPPANLLEGRGTQSGAHVDIMGNFALIEDIMRVAAGGNGSDIGHDQVHSGIFEWSERIDLKL
What is the function of this protein?
Triacylglycerol formation by an acyl-CoA independent pathway.  The enzyme preferentially transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid.  Involved in epoxy and hydroxy fatty acid accumulation in seeds.  Has complementary functions with DAG1 that are essential for triacylglycerol synthesis and normal development of both seeds and pollen.
What are the official names of this protein?
Phospholipid:diacylglycerol acyltransferase 1, AtPDAT.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RSH4A_MOUSE
Sequence: MENSTSLKQEKENQEPGEAERLWQGESDVSPQEPGPPSPEYREEEQRTDTEPAPRMSPSWSHQSRVSLSTGDLTAGPEVSSSPPPPPLQFHSTPLNTETTQDPVAASPTEKTANGIADTGTPYSDPWESSSAAKQSTSHYTSHAEESTFPQSQTPQPDLCGLRDASRNKSKHKGLRFDLLQEEGSDSNCDPDQPEVGASEAAQSMLEVAIQNAKAYLLSTSSKSGLNLYDHLSKVLTKILDERPADAVDIIENISQDVKMAHFNKKLDTLHNEYEMLPAYEIAETQKALFLQGHLEGADSELEEEMAESSLPNVMESAYYFEQAGVGLGTDETYRVFLALKQLTDTHPIQRCRFWGKILGLEMNYIVAEVEFRDGEDEEEVEEEGIAEERDNGGSEAGEEEEEELPKSLYKAPQVIPKEESRTGANKYVYFVCNVPGRPWVRLPSVTPAQIVTARKIKKFFTGRLDAAVISYPPFPGNESNYLRAQIARISAGTHVSPLGFYQFGEEEGEEEEVEGGRDSYEENPDFEGIQVIDLVESLSNWVHHVQYILPQGRCNWFNPIQKDEDEEEEEEEDEEKGEEPDYIEQEVGPPLLTPISEDLGIQNIPSWTTQLSSNLIPQYAIAVLRSNLWPGAYAFSNGKKFENFYIGWGHKYCVENYTPPSPPPVYQEYPSGPEITEMNDPSVEEEQAFRMTQEPVALSTEENEGTEDEDEDDED
What is the function of this protein?
Functions as part of axonemal radial spoke complexes that play an important role in ciliary motility (PubMed:32203505, PubMed:34871179).  Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (PubMed:32203505).
What are the official names of this protein?
Radial spoke head protein 4 homolog A, Radial spoke head-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the flagellar radial spoke RSP4/6 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium. Note=Radial spoke.
Protein: PROF_PRUDU
Sequence: MSWQQYVDDHLMCDIDGNRLTAAAILGQDGSVWSQSATFPAFKPEEIAAILKDFDQPGTLAPTGLFLGGTKYMVIQGEAGAVIRGKKGSGGITVKKTNQALIIGIYDEPLTPGQCNMIVERLGDYLIEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: HVM28_MOUSE
Sequence: EVKLEESGGGLVQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSHNYATHYAESVKGRFTISRDDSKSSVYLQMNNLRAEDTGIYYCTTGFAYWGQGTLVPV
What are the official names of this protein?
Ig heavy chain V-III region U61.
Protein: Y663_HAEIN
Sequence: MLWNWVALVGGIISAVVFSYILQAAYFHELSLLSAVILGIVLIAALALRAFAGKKSVQASYFASTKVKHELRSLIYRKLASMPLNQVNQQSTSSIIQVASEGVEQLEIYFGRYLPQLFYSLLAPLTLFAFLIFFSFKTAIILLICVPLIPMSIIAVNKIAKKLLAKYWSIYVGLGSSFLDNLQGLITLKIYQDDAYKAKAMDKEAEHFRKITMKVLTMQLNSVSLMDLLAYGGAAIGILTALLQFQNAQLSVLGVILFILLSSEFFIPLRLLGSFFHVAMNGKAASDKIFTLLDTPVETQQSAVDFEAKNNVQVEIKDLHFSYSEEKPAITGLNLSILPNQLSVFVGKSGCGKSTLVSLLMGFNKAQQGEILFNGQNALNIDRTSFYQKVSLVSHSSYVFKGTLRENMTMAKIDATDEQIYACLEQVNLAQFVRDNGGLDMQLLSRGANLSGGQIQRLALARALLHNAELYIFDEATSNIDVESEEIILQFIQQFKQQKTIVMISHRLANAVNADCINVLDQGKLIEQGTHKELMEKQGAYAEMFQQQKDLEQIREVANA
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein HI_0663.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS3A_HALS3
Sequence: MSERSVSKQDQEKRWYTVLAPEEFDRAELGETLAEEPDQVYDRTIQAALSDVRDGGDNNIKLTFQIDDVGSDSASTQFVQAELTRDYQRSLVRRGSSKVAVTVTVLTTDDYRVRIQPVAYTTKQADQSQQHAIRRTMIDLVEEAGEERTFEALLNSIIEGRLSSAIYDEANTIYPLRRVEVEKATLEAHPEEVHEEEETAVDFSGE
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: LPXK_PECAS
Sequence: MIERIWSGQSRLYWLLLPLSWLYGLITFLIRQSYRLGWRKSWRSPVPIVVVGNLTAGGNGKTPVVIWLVEQLQRRGYRVGVVSRGYGGKAERYPLLLNESVTTVQAGDEPVLIFQRTGAPVAVAPRRAEAVSALLARHTLDVVITDDGLQHYALARDIELVVIDGMRRFGNGWWLPAGPMRERESRLASVDAVVVNGGVPQTNEIGMTLTAGMAVNLLSGESRSLSQLYDVVAMAGIGHPPRFFATLRDAGVSIAREVAFADHQSYQPEQLALLTQDTMQPLLMTEKDAVKCKAFAQDNWWYLPVDAVLAEPQGTQLLDKLEDMLNRNVGSRT
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.