PharMolix/UniProtQA huggingface dataset:
Protein: ARAB_PECAS
Sequence: MSAGAITIGLDFGSDSVRALAVDCQSGKELETDVVYYPRWREGKYCQPANNQFRHHPLDYIESLEQAIKVVVSRLTNDQRQSIIGIGVDSTGSTPAPIDEQGQILALRPEFANNPNAMFVLWKDHTAIEEADAINALCRSGQFPDYTRYIGGVYSSEWFWAKILHVSREDAAVRQAAVSWIELCDWVPALLSGTQAPADIRRGRCSAGHKSLWHPSWCGLPPKDFLHALDPCLTETLQYPLFTDTWTAEQPVGSITAEWAQRLGIPETVTLAGGAFDCHVGTVGAGAQPYTLVKVIGTSTCDILIADEERIADRTIAGICGQVDGSVVPNYIGLEAGQSAFGDMYAWFGRLLGWSLQEAAKDHPELKTSLQAMEAKLLERLTHNWAENPTLDHLPIVLDWFNGRRTPFANQRLKGVITDLNLGTDAPTLFGGFIAATAFGARAIMECFEEQGVPVENVLALGGIARKSPVIMQVCTDVMNRPLQIVASDQCCALGAAIFAAVAAGVHGDIPTAQQHMASGIERTLMPDSQRVARYQQLYERYQQWCRLAEPAYSPTSTAKN
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: UAP1L_DANRE
Sequence: MSFEEAKAKLEAAGQTHVLQFWDELSAEERGTFLEEISQLQPDELVEHCREAAASASRHSSADGRLDARMQPVPPEFIGSVRKSDRETLQKWENEGLLQISQDRVAVLLLAGGQGTRLGVSYPKGMYNVGLPSGKTLYQIQAERIQKVQELANVRHGCRCTVPWYIMTSEFTLGPTEKFFKDNKYFGLCPSNVVMFEQRMIPAVGFDGKIILEKKNKIAMAPDGNGGLYRSLVDNKILADMERRNVEFLHVYCVDNILVKMADPVFIGFCVTNGADCGAKVVEKAYPAEPVGVVCRVDGVYQVIEYSEIQPETAELRGSGGELVFSAGNICNHFFTRSFLRDVAEKFESKLKQHVAIKKVPFVDGEGNLVKPTKPNGIKMEKFVFDVFQFSKKFVAFEVLREEEFSPLKNADGAPLDTPTTARRSLLAQHYRWILAAGGSFLDEQNKPFTPKHSTAQIEDPPAVCEISPLVSYFGEGLEMLLNQKNLKSPFILDENEAKNLVHTV
What are the official names of this protein?
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 1 family.
Protein: PDXB_PECAS
Sequence: MKILVDENMPYARELFSRLGEVQAVPGRPLPRELLVGADALMVRSVTKVNANLLFGSSVKFVGSATAGTDHVDDTWLNANGIAFSAAPGCNAIAVVEYVFSSLLMLAERDGFQLRDKTVGIVGVGNVGRRLDTRLKAWGVKTLLCDPPRADRGDAGDFLSLETLVRDADILTLHTPLYLDGPYRTHHLVDATVLNAFADGRILINACRGPVVDNAALLEALQQGKKLSVILDVWEPEPGLSTDLLARVDIGTAHIAGYTLEGKARGTTQVFEAWSEFIGTPQQIALSSLLPEPDYAEVTLTAPVDEALLKRLVHLVYDVRRDDALLRHAAHQEGEFDRLRKHYQERREWSSLHVICADVESADCLNALGFNASVRGAR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_CALBD
Sequence: MKLNKVVLAYSGGLDTSVIIPWLKENFDCEVIAVVVDVGQEDDFDAIKEKAYKTGASKVYIEDAKEEFVNEYIFPTLKAGAIYEGKYLLGTSMARPLIAKKLVNIAKKENADAIAHGATGKGNDQVRFEVTIKALMPQIKIIAPWRIWNLKSREDELNYLTQKGIDIPFKKEESYSMDGNIWHLSHEGLDLEDPWNMPDFDKVLKITKNPLKLADLPETVEIEFEKGIPVKVNGQQMGGVELLKTLNKIGSNHGIGIADIVENRLVGMKSRGVYETPGGTILYYAHRELEYLCLDRATLHFKDMVAIRFAELVYDGLWFSPLREALSAFVDKTQEVVNGTVRLVLYRGNIYSAGSKSPNSLYIKDLATFEEDQMYNQKDAEGFINLFGLPLKVFGMVNRKEDE
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_MYCSM
Sequence: MFARHLGLTDFRSWARVDLDLEPGRTVFVGPNGFGKTNLVEALWYSATLGSHRVATDAPLIRAGAERAIVSTIVVNEGRELAVDLEITSGRANKARLNRSPVRSAREILGVLRAVLFSPEDLSLVRGDPGDRRRYLDELATTRRPALAGVRADYDKVVRQRTALLKTAAGARYRGDRSVIDTLEVWDGHLAAHGAALVASRVKLVEELQPEVEKAYQLLAPASRPAAIRYRSSVEAIEDAPGPESVEFYEAALLDALARRRDAELERGVCLVGPHRDDLELRLGDQPAKGFASHGESWSMALALRLGAYELLCSDGVEPVLLLDDVFAELDTSRRRALATVAGSAEQVLVTAAVGEDIPEDWDARRVEIRMVEDDGGRVSMVAS
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP (By similarity).
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_HALOH
Sequence: MKKGIHPEIKKTKIVCACGAEYETNSTKEDIHVEVCSRCHPFYTGKQRKATKGGRIERFNKKYGLSEE
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: ADDA_BACAH
Sequence: MIENWPKKPEGSQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIINEENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEPGSQHVRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTENELLKEEVLDDILEEEYGIEDNTIFFELVDRYTSDRSDDDLQRMILALHTESRAHPNPEKWLDKLVEAYDVEGKTIEDLVYASYLLEDVKFQLETAEQHIRKATELAMLPDGPAPRIETLQADLALLGTLSSAARESWTSVYEAMQNVSWQTLKRIKKSDYNEDIVKQVDSLRNKAKDEVKKLQEELFSRRPESFLRDFQDMHPVLEKLVQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSEDGEMKPSAVALQYRNKFAEVLVDEYQDTNFVQESIIKFVTKDSESEGNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEGLGGGMKIDLAKNFRSRHEVLAGTNFIFKQIMGEEVGEIDYDADAELKLGASYPEGEDVAAELLCIQQTEEEVIDGEEGAEVEKAQLEARLMAQRIKAMVDSGYEVYDRKTDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLNDEELATLRAHGKKGSFYEVMSSFLKGAPLEEEKELHDKLEWFYNLLQGWREFARQQSLSDLIWKVYGETGYYDFVGGLPAGKQRQANLRVLYDRARQYEATSFRGLFRFLRFIERILERGDDMGTARALGEQEDVVRIMTIHKSKGLEFPVVFVAGLGRRFNTQDLMKRFLLHKDFGFGSQFIDPRKRIKYTTLSQLAIKRKMKMELIAEEMRVLYVALTRAKEKLILIGTVKDATKEMEKWLDAREHSEWLLPDHVRAGASCYLDWIAPSLYRHRDSEMLLELGQGSIPDEIYGYDTSWKVEVVDGNTLLAPEPVQEEKQELLEALREKKAVPLQSERKDEVYDRLMWKYGYEEATSHRAKQSVTEIKRNYQSEEGSDNAFIKKLRAPIKTRPRFMEKKGLTYAERGTAVHAVMQHVDLKKPITVEVLQEQIAGMVNKELLTFEQAEEIAVEKVISFFDSDLGKRVLAAKSVEREVPFTMMLAAEEAYQDWQGESGESILVQGVIDCMIEEEDGITLIDFKTDTIEGKFPGGFEQAKPILETRYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVIKVEE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: S38A6_HUMAN
Sequence: MEASWGSFNAERGWYVSVQQPEEAEAEELSPLLSNELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFDWINK
What is the function of this protein?
Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.
What are the official names of this protein?
Probable sodium-coupled neutral amino acid transporter 6, N-system amino acid transporter 1, NAT-1, Na(+)-coupled neutral amino acid transporter 6, Solute carrier family 38 member 6.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Colocalizes with synaptotagmins and SNAP25.
Protein: LEG3_RABIT
Sequence: MADGFSLNDALSGSGHPPNQGWPGPWGNQPAGPGGYPGAAYPGAYPGHAPGAYPGQAPPGPYPGPGAHGAYPGQPGGPGAYPSPGQPSGAGAYPGASPYSASAGPLPVPYDLPLPGGVMPRMLITIVGTVKPNANRLALDFKRGNDVAFHFNPRFNENNRRVIVCNTKVDNNWGREERQTTFPFEIGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRMRNLKEINKLGISGDIQLTSASHAMI
What is the function of this protein?
Galactose-specific lectin which binds IgE.  May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration.  Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.  In the nucleus: acts as a pre-mRNA splicing factor.  Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.  Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
What are the official names of this protein?
Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, IgE-binding protein, Laminin-binding protein, Lectin L-29, Mac-2 antigen.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum- Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: YCJF_ECOHS
Sequence: MTEPLKPRIDFDGPLEVDQNPKFRAQQTFDENQAQNFAPATLDEAQEEEGQVEAVMDAALRPKRSLWRKMVMGGLALFGASVVGQGVQWTMNAWQTQDWVALGGCAAGALIIGAGVGSVVTEWRRLWRLRQRAHERDEARDLLHSHGTGKGRAFCEKLAQQAGIDQSHPALQRWYASIHETQNDREVVSLYAHLVQPVLDAQARREISRSAAESTLMIAVSPLALVDMAFIAWRNLRLINRIATLYGIELGYYSRLRLFKLVLLNIAFAGASELVREVGMDWMSQDLAARLSTRAAQGIGAGLLTARLGIKAMELCRPLPWIDDDKPRLGDFRRQLIGQVKETLQKGKTPSEK
What are the official names of this protein?
UPF0283 membrane protein YcjF.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACTH_THEVO
Sequence: MVVIGLDVGYGDTKVIGIDGKRIIFPSRWAVTETESWGIGGKIPVLSTDGGQTKFIYGRYASGNNIRVPQGDGRLASKEAFPLIAAALWESGIHNDGSPVDLVIGSGTPLGTFDLEVKAAKEALENKILTVTGPEGEVRQYNVTRLIMRPQGVGAALYLLNQGIIEQQPGYGVVIDVGSRTTDVLTINLMDMEPVVELSFSLQIGVGDAISNLSRKIAKETGFVVPFDLAQEALSKPVMFRQKQVGGPEVAGPILEDLANRIIENIRLNLRGEVDRITSLIPVGGGANLIGDRFDEIAPGTTVRIKPEDLQFANALGYRDAAERSM
What is the function of this protein?
Polymerizes into bundles of filaments.  Polymerization requires NTP and is optimal with ATP, but GTP, UTP, CTP, and even the deoxy form of NTP can also support the polymerization reaction (By similarity).
What are the official names of this protein?
Archaeal actin homolog.
What is the protein family that this protein belongs to?
Belongs to the thermophilic archaeal actin family.
Protein: PG060_VACCC
Sequence: MRSIAGLHKLKMEIFNVEELINMKPFKNMNKITINQNDNCILANRCFVKIDTPRYIPSTSISSSNIIRIRNHDFTLSELLYSPFHFQQPQFQYLLPGFVLTCIDKVSKQQKECKYCISNRGDDDSLSINLFIPTINKSIYIIIGLRMKNFWKPKFEIE
What are the official names of this protein?
Protein OPG060, Protein F15.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG058 family.
Protein: FMT_DICNV
Sequence: MIKPQIWFAGTPEFATAALDALVKHVSVAGVLTQPDRPAGRGRKLKASAVKARAEHYQLPIAQPERLQESAPPFAHLPRPDIVVVVAYGLLLPQWFLDYPRLGCINIHASLLPRWRGAAPIQRAIEAGDEETGISIMQMDAGLDTGAVWLEKRLPIGEQSASQLHDALMQLGAEALIDVLPDILAQARAPIPQPSSGACYAHKLSKAEAEINWQDDAANIVRKIRAFDLFPVAYSYLDDAPVRFYDGIALSEHTESAPAGTVIEHNQEGIDIVCGSGILRIKRLQLAGKNVVSAAALANGCHLKGRHFARKNQL
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: BST1_ASPFU
Sequence: MHRRSSGSPVEDDAEDSPLVSRSPTESTAHGPNNNAFETAEKSRSQIAKRGTSFDLRRDNGASTPRSRNSGLWRTPSSSSTSSTTAMATASTETKSSSASFLMPLASQRLPMGTSPESSRFRSSRLRSPWTCSILTALTTLVASVFLFFIVRSFSARQAGEDGCGIPVMSPTFLHMVGFDTEHTRFASKYNLYLYREEGVDFYNQENLGLNGAPVLFLPGNAGSYRQVRSLAAEASRHFHDVVRHDQERIKAGTRSLDFFMIDFNEDMAAFHGQTLLDQAEYVNEAIAYILSLYHDPKRSRRDPELPDPSSVILIGHSMGGIVARTALTMSNYQANSVNTIVTMSAPHAKPPVSFDSDIVHTYKQINDYWREAYSQTWANNNPLWHVTLISIAGGSRDTVVPSDYASISSLVPETHGFTVFTSSIPDVWIGVDHLSITWCDQFRKAIIKSLFDIIDVRRASQTKPRAERMRIFKKWYLTGLEPVAERTLSQKEPNTLLTLEDKSNSILPQGQRLILRELGHRSGPKVYLLPVPPQGVSGKKFTLLTDQRFDKTGEHGNLEVLFCSVFPLQNGKFATVFSMNMDFSGGNTGSTRLACKNAAEDGIHLPASTPASKYPFDRVQPFSYLQYELEDLSEHQFVAIVDKADSPTKGWVLAEFSDSSDAVIRVRGGLGGLLSAGLKMRLPANRPMLTEIKIPALHSSLLDYKLQIVRHNHDKRQELFAPLLRQSISDPHESKFFVNVDKVDVNLHGVAPFMPPPLREQATLGGVSFQLWTDPSCGSTVDVSLKVDIAGSLGELVMRYRTVFAAFPLLVVALVLRKQFQMYDETGYFITFAEGLDTALRSSFPILLLAMSLLASSLATSAQIPPSDEPFQWPVNATETPIDFTKNDLLLGSQDAFFWFLVPVFGLISVGVCVILNYIALILLSVLSFIYGCLRTRSGYIKRNEKGTPIFSAPTARRRMINTAILLVLVSTLIPYQFAYMVACIVQLATCVRAQWHAKETRSTAHYNFSNYAHSIFILMLWILPINILVLLVWAHNLVVHWFMPFSSHHNVLSIMPFILLVETMTSGAMIPRVTTRLKHVTSMILFAIAVYSAVYGVSYAYLLHHLANILAAWFVVIYFFSSGFSLRRLWLILEGDDATQGKSEPGGSHQKKKP
What is the function of this protein?
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
What are the official names of this protein?
GPI inositol-deacylase.
What is the protein family that this protein belongs to?
Belongs to the GPI inositol-deacylase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ATPF_SPHAL
Sequence: MADFTLILAEGVVEPTAFGLDATVWVSIAMLVFLGILVWKGVPGAIAAMLDKRIAEISKQLGEAEQLRLDAESLKAEYEAKLADAAKEADEMRARADAEAQALVAKAKADATALIARRKQMAEDRIAAAEANALAEVRAAAVKAATEAAAKLIADRHDVAADKALVDQAIASIAKG
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YTHD3_MOUSE
Sequence: MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTNQNNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQNSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNNVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQSQQPQLQNRWVAPRNRGTGFNQNNGTGSENFGLGVVPVSASPSSVEVHPVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ
What is the function of this protein?
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:32905781, PubMed:32943573).  M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:32943573).  Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32943573, PubMed:32905781).  The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:32943573).  Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (PubMed:30591559).  Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (PubMed:30591559).  Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (By similarity).  Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (By similarity).  Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (By similarity).  The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (By similarity).  May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (By similarity).
What are the official names of this protein?
YTH domain-containing family protein 3.
What is the protein family that this protein belongs to?
Belongs to the YTHDF family. YTHDF3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, P-body. Cytoplasm, Stress granule.
Protein: SYDC_MOUSE
Sequence: MPSTNASRKGQEKPREIVDAAEDYAKERYGISSMIQSQEKPDRVLVRVKDLTVQKADDVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVSKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP
What is the function of this protein?
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
What are the official names of this protein?
Aspartate--tRNA ligase, cytoplasmic, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS25_SHEEP
Sequence: MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S25.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS25 family.
Protein: SYGB_RICAE
Sequence: MSELLLELFSEEMPAFMQKNAEEGYLNIFTKIFEENEIFAKVQVFVGPRRITLHATHLPKITLPKEEEIKGPSIEAPEAAINGFCKAHNVSKLELPTKLISNQLYYFFVKKTEEREIKEILPEIIIEAINKYSWAKSMFWGDYKIKWIRPLRNILCIFDGEILPMQFGHLTANNITYGHRLTDNKKLEVTDFEDYRNKLLENHVILERAKREAIIKTGLLELANSHELIIKEDNRLVEEVVGLSEFPVVLLGKIPQKFLELPKEVLISSMRTHQKYFCLFDKTGNFTPYFLFVSNGRFTNAELVIQGNEKVLSARLSDALYFCKQDIAKTLESRLGQLEAATFHAKLGNLREKIERITDICNYIAPNNKDLITAARLCKSDLVSEMVGEFPDLQGIMGYYYAKHEGLNAEIAAAIRDHYKPQGLSDNLPSGNAALLALADKLDSLVGLMIAGETPTGSGDPYALRRQALGIIRIILENKLELNFNDLINFSINLYKDSSDENKNLIISFFKERAKFYFKNDYDIALINAVLDLNLVDTNFKLDALKEFLIEDAGKQLLNAYKRASNIIGDQKITGLVDASLFSTQPEKELFEVIQKISPQIIDSIADKDYKKALNLLSSLLTPITSFFDNVLVNDSDPKIAQNRLSLLQNICELFDKVAKFNRL
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1005_METJA
Sequence: MRIEDEIKNIIEKKDYDFWEFLKKAYENNIKLDIGHFILLNILIGVNDLYHKLSEKFGEEEARKILERNKIFAKNSDFISGEFLKDYIDRKSRVAVHNRIKDLKTLGFKIESKSGPFGGYKIVGYPEWFKK
What are the official names of this protein?
Uncharacterized protein MJ1005.
Protein: LOLB_XANOR
Sequence: MSKALRTLALSGLVLVGLSACVSVPRGQGSGAAVVEQISDSARQGEAARQAWLQQHPNWSFQGRVAISKDRNGGSGRIDWQQDGPRYRVQLSAPVTRQSWVLTGDTTTGAGRLEGLDGGPRSGSDAEKVLLEATGWTIPVNQMPDWVRALRIADAGAARVELDAAGRPRTVQQDGWTIDFLAWTPASADQPELPQRIEARYGEAKVRLLVDQWTVSP
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: DNAA_GEODF
Sequence: MEKIWLEAQSNIKKVLTPQTYNTWIKPIHFHNVSDTNLTLEVPSKFIKEWVTEKYLSIIIEAISSLTNIKYQVDFKITEKSQVEKKKVDLQATEKIENDSTRNVDFNTNLNPKYTFDSFVCGASNQFAHAASQAVANNPACNYNPLFIYGGVGLGKTHLLIAIGNQIRENNKKAKICYYSSEKFMNEMINSLRYKKMDEFRNKFRKMDILLIDDIQFMAGKEATQEEFFHTFNALYESHKQIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQPPDIETKIAILKKKSDLNSITLPNDVALFLASSATSNVRELEGMLIRLGAYASLTGSEISLNMARDILKDIIVEKTKDITVEMIQKHVADHFKIKVSELKSDKRLKTFVIPRQIAIYISRELTKASYPEIGERFGGKDHSTIIHSVKKIEKQMENDLEIKNTVEKMKKELMS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAR1S_XENLA
Sequence: MYPAYNPYSYRYLNPRNKGMSWRQKNYLASYGDTGDYCDNYQRAQLKAILSQVNPNLTPRLCRANTRDVGVQVNPRQDASVQCSLGPRTLLRRRPGALRKPPPEQGSPASPTKTVRFPRTIAVYSPVAAGRLAPFQDEGVNLEEKGEAVRSEGSEGGRQEGKQGDGEIKEQMKMDKTDEEEAAPAQTRPKFQFLEQKYGYYHCKDCNIRWESAYVWCVQETNKVYFKQFCRTCQKSYNPYRVEDIMCQSCKQTRCACPVKLRHVDPKRPHRQDLCGRCKGKRLSCDSTFSFKYII
What is the function of this protein?
mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:23827238).  Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity).  Binds to the 3'-UTR of maternal mRNAs in immature oocytes, inhibiting their translation (PubMed:23827238).
What are the official names of this protein?
Zygote arrest protein 1.S.
What is the protein family that this protein belongs to?
Belongs to the ZAR1 family.
Protein: RS11_KORVE
Sequence: MAKAAGSAAAGEKKGKTNKKFKKKERKHVPHGLAHIQASFNNTIVTISDPSGNVVSWKSSGSLGFRGSRKGTPFAAQQAAMTAANMARDHGMRSLDVRVAGPGSGRESAVRALAAAGLDVRVIRDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: PDXY_PARXL
Sequence: MTKNVLSIQSHVVFGHAGNSAAVFPMRRLGVNVWPLNTVQFSNHTQYGHWTGGAIDATQMVELVDGIGAIGMLPRCDAVLSGYLGTPEQAQSVLEIVKAVKAANPRAWYFCDPVMGAVSGCKVEPGIQEFLVRTMPGVADAMAPNHTELQRLVGREIETLEEAVTACRELIARGPKLVLVKHLLDRNSPADRFNMLVVTEREAWMGQRPLYPFARQPVGVGDLTSAVFVARTLLGDSIRAAFEHTLAAVNAVVKATWQAGRYELELVAAQSEIAQPREWFDAWVGDTA
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.