PharMolix/UniProtQA huggingface dataset:
Protein: CYAA_BACAN
Sequence: MTRNKFIPNKFSIISFSVLLFAISSSQAIEVNAMNEHYTESDIKRNHKTEKNKTEKEKFKDSINNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIIDEK
What is the function of this protein?
Edema factor (EF), which constitutes one of the three proteins composing the anthrax toxin, causes edema in the host (PubMed:6285339, PubMed:2108958, PubMed:11807546).  Acts as a calmodulin-dependent adenylyl cyclase by converting ATP to cAMP, leading to dramatic elevation of intracellular cAMP levels in the host, thereby causing edema (PubMed:6285339, PubMed:2108958, PubMed:11807546).  EF is not toxic by itself and only acts as a edema factor when associated with protective antigen (PA) to form the edema toxin (EdTx) (PubMed:11553601, PubMed:2108958).  Required for the survival of germinated spores within macrophages at the early stages of infection (PubMed:11737637).
What are the official names of this protein?
Calmodulin-sensitive adenylate cyclase, ATP pyrophosphate-lyase, Adenylyl cyclase, Anthrax edema toxin adenylate cyclase component, Edema factor, EF.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-2 family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm, host cytosol. Note=Translocation into host cytosol is mediated via interaction with the cleaved form of protective antigen (PA-63): following secretion, EF binds via its N-terminal region to the upper rim of the ring-shaped homooligomer (homoheptamer or homooctamer) formed by PA-63 on the host cell membrane (PubMed:32047164). In this PA-63 pre-pore state, the N- terminal segment of EF refolds into an alpha helix engaged in the alpha-clamp of the PA-63 pre-pore (PubMed:32047164, PubMed:32521227). Recruitment to the PA-63 pre-pore enables domain reorganization of EF (PubMed:32521227). Loaded complexes are then endocytosed, followed by a conformational change of oligomerized PA-63 from the pre-pore to pore state, which is triggered by the low pH in the endosome (PubMed:11207582). EF is then unfolded to pass through the PA-63 pore and translocate into the host cytosol (PubMed:32047164).
Protein: HIS5_BUCAI
Sequence: MYIVIVDTGCANLTSIKVAINNLGYNATITSESSIILKSNKIFLPGVGTASAVMDLLSKKKIINVIRECKQTILGICLGMQLFCASSEESNGVKTIGIIKTPALRLKVNNLSLPHIGWNQITFQKGHALFKNIPNNSRFYFVHSYMVPINKYTLSTTNYGINFSSIIQKDNFFGVQFHPEKSGNIGSQLLKNFLEI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGS7_HUMAN
Sequence: MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
What is the function of this protein?
Regulates G protein-coupled receptor signaling cascades.  Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767).  The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509).  May play a role in synaptic vesicle exocytosis (PubMed:12659861).  Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).
What are the official names of this protein?
Regulator of G-protein signaling 7, RGS7.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264).
Protein: Y915_STRPB
Sequence: MYSIKCDDNKAMPRERLMRLGAESLSNQELLAILLRTGNKEKHVLELSSYLLSHLDSLADFKKMSLQELQHLAGIGKVKAIEIKAMIELVSRILATDKTLTDSVLTSVQVAEKMMAALGDKKQEHLVVLYLDNQNRIIEEKTIFIGTVRRSLAEPREILYYACKNMATSLIVIHNHPSGNIEPSSNDYCFTEKIKRSCEDLGIICLDHIIVSYKDYYSFREKSTLF
What are the official names of this protein?
UPF0758 protein MGAS2096_Spy0915.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: CADH5_ORYSJ
Sequence: MAPTAAAGLAARDASGHLSPLTISRRSTGDDDVVIKILYCGICHSDLHSIKNEWKNATYPLVPGHEIAGVVTEAGKNVTKFKGGDKVGVGCMVNSCHSCDSCNQGLENHCPGVIFTYNSVDKDGTVTYGGYSSMVVVHERFVVRFPEAMPLDKGAPLLCAGITVYSPMKYHGLNVPSKHVGVLGLGGLGHVAVKFAKAFGMTVTVISSSPGKRQEALERLGADAFVVSKNADEMNAATGTMDGIINTVSANIPIAPLLGLLKPNGKMILVGLPEKPMEIPPFALVASNKTLAGSCIGGMADTEMIDLAAKHGVTAEIEVIGADYVNTAMERLAKADVRYRFVIDIGNTLKDAIE
What is the function of this protein?
Involved in lignin biosynthesis.  Catalyzes the final step specific for the production of lignin monomers.  Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
What are the official names of this protein?
Probable cinnamyl alcohol dehydrogenase 5, OsCAD5.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: SECDF_BRUAB
Sequence: MLYFSRWKSALIWLAVLVSLIIASPNFFSRETLENLPDFLPKKQVSLGLDLSGGSRLILQVQNAGKTDLETTANIMRQRLEELGYGNPVVEGEGRNQIRVEVPGLYDAQLLKDILTIRGNLSFRAMDDTMSPDDAIRGTPPADSEIVYSFDDPPVGYLLKKTPILTGHDITDAKASISADDGQPVITLTLDDNGRRRLADLTAQGNENSFAIVVDNQVVSAPTVSGPLDTSELQIEGAFDLQAANNMAVVLRSGALPQAVTVLEERTIASALGEDYASAAVLAALLAALVVGLFMVLSYGILGVIALVALVVNIVILTAVLSLIGASISLASIAGLVLTIGLAVDAHILIYERVREDRRKGYSVVQAMESGFYRALSTIVDANLTTLIAALVLFLLGSGTVHGFALTVAIGIGTTLFTTLTFTRLLIAQWVRTAKPKEVPKRRLKLVPTVTHIPFMRLQFVTLGISVLACAIVVALFVNIGFNYGIDFRGGSMVELQARNGDANLEDINERLAELNIDSARVLPAKSPRSALVIIGSQEVGDDAEQTVAVKLRGEFEQDYSFQRVDVVGPTVSEQLSRAGVLAVILSLIGIFIYVWFRFRWQLALGAVLSTLHDVVILSGMFIVFRMEFNLWSVAAILTIIGYSLNDTVVIYDRVRENLRRYKSAPLPAIIDASINQTLSRTLLTSFVTFLAHVPLYAFGGSEIRMFALALSVGIIVASYSSIFIAAPLLVQFGLKPRETDAGDAVDAELAQSLNLES
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity).
What are the official names of this protein?
Protein translocase subunit SecDF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the SecD/SecF family. SecF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CB23_TETTH
Sequence: MEHQIITQNVYAPDTEAKLDVARKLFAQFDSNKNGTLDPSEVAGLIKTTFENMGVKDYSVTADDVKLYMKSVDVDNNGLVSYSEYEEYVIACLKKAGFDCEVKQKVKRSAKKRDAATEMKLDVARRLFAKYDSDKSGQLEEKEVYGVITETYKQMGMDYKPTEADVKLWMSMTDTDKNGTVSIVEYEDFVISGLKKAGFMVKEFTQA
What is the function of this protein?
Expected to play a crucial role in calcium-dependent regulation of ciliary movement.
What are the official names of this protein?
23 kDa calcium-binding protein, TCBP-23.
Protein: PCP13_ARATH
Sequence: MARPRISISMICLLILIVGFVLQSSQARKVLVPYGTSKGLFLSALPKGNVPPSGPSDKGHTSPPDDTDQRMVPENSPEIYRRLESVPSPGVGH
What is the function of this protein?
Extracellular signaling peptide that may regulate primary root growth rate and systemic nitrogen (N)-demand signaling.
What are the official names of this protein?
Precursor of CEP13, PCEP13.
What is the protein family that this protein belongs to?
Belongs to the C-terminally encoded plant signaling peptide (CEP) family.
What are the subcellular locations of this protein?
[C-terminally encoded peptide 13]: Secreted, extracellular space, apoplast. Note=Accumulates in xylem sap.
Protein: YDEO_ECOL6
Sequence: MSLVCSVIFIHHAFNANILYKDYAFSDGEILMVDNAVRTHFEPYERHFKEIGFNENTIKKYLQCTNIQTVTVPVPAKFLRASNVPTGLLNEMIAYLNSEERNHHNFSELLLFSCLSIFAACKGFITLLTNGVLSVSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIRVEGSVNKIAEQCGYASTSYFIYAFRKHFGNSPKRVSKEYRCQRRTGMNTDNTMNALAI
What is the function of this protein?
Induces the expression of gadE and mdtEF.  Could also regulate the expression of other genes involved in acid resistance (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator YdeO.
Protein: THIE_THET8
Sequence: MLGRLYLVVTPRPGWSLEATLDRTERALAGGVEVVQLRAKDWEARPTLALGERMLALARRYGVPFFLNDRPDLAALLGADGVHLGQNDLTPEEARRFFAGMVGRSTHAPEQALRALEEGVDYLSVGPVWETPTKPGRPAAGLAYVRWAAENLGEKPWYAIGGIDLGNLDQVLEAGARRIVVVRAILDAPDPERAARALRERLYGVA
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: GPDA_STRGC
Sequence: MDKQRVAVIGPGSWGTALSQVLNDNGHEVRIWGNIAEQIDEINQAHTNTRYFKDTVLDEKIKAYHSLAEALDGADAVLFVVPTKVTRLVAKQVAQILDHNVKVMHASKGLEPDSHERISTILEEEIPSELRSEIVVVSGPSHAEETIVRDITLITAASKDLEAAKYVQKLFSNHYFRLYTNTDVVGVETAGALKNIIAVGAGALHGLGYGDNAKAAIITRGLAEITRLGVKLGASPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGEKLADIEANMGMVIEGISTTKAAYELAQELDVYMPITQAIYKVIYQGHDIKEAIFEIMNNEFKAENEWS
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_MYCGE
Sequence: MKLLRFLVLSPSGIKLDKTIISAQVKTTEGYIGLNFNRAPLIAAIQSHLCKIIFADQTKREAIIGAGLMLIKKTEAKIFTENFVFADEVDINETLKRKTELERKIHHIKDAKLNVKIEQNLMFELLKLSSKKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TILS_HELMO
Sequence: MNHLLQRFSQSLCRLGINKPRERIVIALSGGADSVCLLLLFKKVSPQFGIELAAAHYNHGMRGKESDEDAAFVAELTNRLQVPLFLETAPLKWWQQEPGTKMEAARRLRYDFLSRSAEQAGARWIALAHHADDMAETVLFHMLRGSGIKGLSGIPAKRGPFVRPLLPFRRKELEEFLKAEGQHWRHDSSNDSDVYTRNRIRHQIMPALLSFNPKLVETLCRNADLLRADAEFLDRECELVYGQVQQEEGLKVQALVDLPLALRRRVLRRFLEPENPGSEKTDAILEQLQKNFGRSKIVDQVGGKYLINEGGILRSYEELPWLENQDFFYPIAIPKEKNHSVRLEVPEAEGSLEVTLSTKKPVSLMHDEGPPSKPMKTALQLKAEVLQRGPLSIRNRRPGDWLSLAGRAGRKKLKEFFIDKKIPRQLRDRIPLLTSGEEVLWVIGCWTGCHDTIDQPGQDVITFQWYGKTI
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAEX_ECOLU
Sequence: MSLFPVIVVFGLSFPPIFFELLLSLAIFWLVRRVLVPTGIYDFVWHPALFNTALYCCLFYLISRLFV
What are the official names of this protein?
Protein AaeX.
What is the protein family that this protein belongs to?
Belongs to the AaeX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NRTB_SYNY3
Sequence: MASSTAGLRPRRKKNPLSFIYSPKVIRPAVAIAVLLVVWQILCSGEGSNLPSPVQVLEQTYPLILNPFFDNGGTDKGLGIQIFASLTRVAVGFSAAAVVGIALGILIGSSKFMYDALDPIFQVLRTIPPLAWLPIALAALQEAEPSAIFVIFITAIWPIVINTTVGAQQVPQDYRNVSRVLKLSKSQYFFNILFPAAVPYIFTGLRIGIGLSWLAIVAAEMLIGGVGIGFFIWDAYNSSLISEIIIALIYVGIVGLLLDRFIAFLESLVVPAEQK
What is the function of this protein?
Part of the ABC transporter complex NrtABCD involved in nitrate uptake.  The complex is probably also involved in nitrite transport.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Nitrate import permease protein NrtB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNTP_BACTN
Sequence: MTGLEIWLLAIGLAMDCFAVSIASGIILKRTQWRPMLVMALAFGLFQALMPFIGWMFAKTFSHLIESVDHWIAFAILAFLGGRMILESFKDEDCRQTFNPASPKVVFTMAIATSIDALAIGISFALLGINNYTEILSPILIIGFVSFVMSLIGLYFGIKCGCGCARKLKAELWGGIILVAIGLKILIEHLFLQ
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: T106B_RAT
Sequence: MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVRNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDSQKRMIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLSNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLPSIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ
What is the function of this protein?
In neurons, involved in the transport of late endosomes/lysosomes (PubMed:24357581).  May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:24357581).  May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (PubMed:24357581).  In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity).  It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (By similarity).  In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (By similarity).  Required for proper lysosomal acidification (By similarity).
What are the official names of this protein?
Transmembrane protein 106B.
What is the protein family that this protein belongs to?
Belongs to the TMEM106 family.
What are the subcellular locations of this protein?
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor.
Protein: GFA_FUSV7
Sequence: MSLPLHPSLNNGITKGSANFSGGKLRCKCSSSPVEVTLAGNVAHNHACGCSKCWKPEGAIFSVIGVIPKEQVSVTANADKLYIVDESAAIQRHACSGCGVHLYGRIEKEHPFKGLDFVHTELSSEKGWQEPQFAAFVSSIIEQGFDPSKMDAVRAQFKSIGLETYDALNPPLMDAIASWTAQKAKI
What is the function of this protein?
Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.
What are the official names of this protein?
Putative glutathione-dependent formaldehyde-activating enzyme, S-(hydroxymethyl)glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the Gfa family.
Protein: PEPB_SERP5
Sequence: MTTEFMLVTLSNQSADARWGEKALLSTGAEGMTIHLTGKDKLGSIQRAARKIDGQGIKNVKLAGDGWDLENSWAFWQGFRGPKGKRSVEWAPLPAAESKELEQRLKIVDWVRDTINMSAEELGPEQLATRAVDLMCDIGCEAVSYRITKGEDLREQNYAGIHTVGRGSDRSPVLLALDFNPTGNPEAPVFACLVGKGITFDTGGYSLKQSAFMDSMKADMGGAATITGALALAAARGLKQRVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEVMNTDAEGRLVLADGLIDASAQNPQLIIDCATLTGAAKTAVGNDYHALFSFDDALAQELLASAAAEQEPFWRLPLAEFHRSQLPSNFAELNNVAGPAYTAGASTAAAFLSHFVTNYQQGWLHIDCSATYRKGAVDQWSAGATGLGVRALANLLLSKAR
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation.
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOF_BACCZ
Sequence: MNQPWRTHLQTKLQQLHEQGQYRNLHVTEQAEETWLIRDEKRMLNLASNNYLGLSGDERLKEAAIASTRKYGAGATASRLVVGNYSLYEEVERSICDWKGTEKALVVSSGYTANVGVISSLACRHDIVFSDKLNHASIVDGIILSGAEHKRYRHNDLNHLEALLKTASPEKRKLIVTDTVFSMDGDTAYLRELVQLKEKYGAIIIVDEAHASGIYGIGGAGLSHIEKDLAQKIDIHMGTFSKALGCYGAYLTGDAIYIEYLQNMMRSFIFTTALPPSTLGAVQKAIEIVQEDHKRRENLIANGEYFRSKLREAGFNIGNSSTHIVPIVVGSNENTLRFSKRLQEAGIAAIAIRPPTVPVHSSRIRFAVTSEHTIADLKWAIERITHIAKEEELFV
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: RS19_CROS5
Sequence: MSRSLKKGPFIADSLLTKIEKLNEKGDKQVIKTWSRASTIIPAMIGHTIAVHNGKQHVPIFISEQMVGHKLGEFAPTRTFRGHSKGDKKARR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SCONB_TRIVH
Sequence: MDTDNSTLPTEQSAVRETCDRDVTMSPRKRRRLSVSLEPELTEPEAAGTPGERCSTADTPESTASEPRSLFNSTPTEGNIAPFLTKHIKDQHASRNRFAPIDSSLPRRKADSKYCYRHRPDLKCRRQAAEPTVDQMQRDLSTLSQNDQQSIAHFWSLFSAAPSKHRNLMLQGIVAQCCFPQLSFLSASVRDLIRIDFVTALPPEISFKILSYLDTASLCSAAQVSHSWRALADDDVVWHRMCEQHIDRKCEKCGWGLPMLDRKRLKDTKRQVQLRAAGKEIAPNQRPQQQHRPWKAVYMDRFKVGTNWKYGRCTTTIFRGHTNGVMCLQFDDNILATGSYDATIKIWDIETGKEIRTLRGHESTIRCLQFDDTKLISGSLDRTIKVWNWRSGECISTYTGHQGGVLCLHFDSTTLASGSKDNTIKIWNFHDKSTRILRGHADWVNSVKLDTASRTVFSASDDLTVRIWDLDTGKCIHSYAGHVGQVQQVLPLPREFEFKHQSNCADDRSDRLSGSESPDHRGSHGYGSNNAPDQQPNTSAPPTEPMSPLFEALFTEDQGRPAPPRYMLTAALDLTLRLWEVHTGRCLRTFFGHIEGVWGLAADTLRFVSGAQDHMAKVWDPRTGTCERTFTGHRGPVTCVSLSDSRMATGSEDSEVRMYSFKA
What is the function of this protein?
Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
What are the official names of this protein?
Probable E3 ubiquitin ligase complex SCF subunit sconB, Sulfur controller B, Sulfur metabolite repression control protein B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MET30/SCONB/SCON-2 family.
Protein: RS15_MYCPN
Sequence: MQIDKNGIIKSAQLHDKDVGSIQVQVSLLTSQIKQLTDHLLANKKDFISKRGLYAKVSKRKRLLKYLKHNDLEAYRNLVKTLNLRG
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: CP27A_MOUSE
Sequence: MAAWSRTRLRWTLLDPRVVGRGLCPQGARAKATIPAALQAQESTEGPGTGQDRPRLRSPAELPGTGTLQFLFQLFLQGYVLHLPDLQVLNKTKYGPMWTTSFGTYTNVNLASAPLLEQVMRQEGKYPIRDHMDQWKDHRDHKGLTYGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVISDFITRLDQVRAESESGDQVPDMAHLLYHLALEAITYILFEKRIGCLKPSIPEDTAAFIRSVAIMFQNSVYITFLPKWTRPLLPFWKRYLNGWDNIFSFGKKLIDEKVQELKAQLQETGPDGVRVSGYLHFLLTNELLSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEVTGVVPFGKVPQHKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPNSFQPHRWLRKKEADNPGILHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEIALAPGMGEVKTVSRIVLVPSKKVRLHFLQRQ
What is the function of this protein?
Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives.  Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid.  Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways.  May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism (By similarity).  Plays a role in cholestanol metabolism in the cerebellum (PubMed:28190002).  Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation.  Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium.  May play a redundant role in vitamin D biosynthesis.  Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (By similarity).
What are the official names of this protein?
Sterol 26-hydroxylase, mitochondrial, 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase, Cytochrome P-450C27/25, Cytochrome P450 27, Sterol 27-hydroxylase, Vitamin D(3) 25-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Post-translationally targeted to mitochondria. All three of the receptor proteins in the TOM complex, TOMM70, TOMM20 and TOMM22 are required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein.