PharMolix/UniProtQA huggingface dataset:
Protein: TUSE_ECO57
Sequence: MLIFEGKEIETDTEGYLKESSQWSEPLAVVIAENEGISLSPEHWEVVRFVRDFYLEFNTSPAIRMLVKAMANKFGEEKGNSRYLYRLFPKGPAKQATKIAGLPKPVKCI
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Could accept sulfur from TusD (By similarity).
What are the official names of this protein?
Sulfurtransferase TusE, tRNA 2-thiouridine synthesizing protein E.
What is the protein family that this protein belongs to?
Belongs to the DsrC/TusE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_BUCBP
Sequence: MSRIAKQPIVIPSDVSITLIGQMVIVKGSKGELKRLIHDSVLVKSVKSCLVFSSRINSSVKGWAQAGTARSLVNSMIHGVTVGFFKKLKLFGVGYRISINSSKNLNMSLGYSHIIEYVLPFGIFVESISQAEIIVKGINKQLVGQVAANLRAYRKSEPYKGKGIRYSNEIVRVKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: YOR6_TTV1K
Sequence: MRHAPSYLSRLFTIVDFYWDFSMIRPICTIWTYSISCTYGIYLLILIYRIFSIFGLDYYHDSLLYSLIFLFYC
What are the official names of this protein?
Uncharacterized 8.9 kDa protein.
Protein: PGMC_ASPTN
Sequence: MTDDIAPSGYQPHRISTLAVLIGFIALLTAWLRRDRRLASIPGPRTYPLVGLGYKLPPKAPALFRKWAMEYGDVFRIRVGWYDWVVINSPEAIAEILEKQAVKTSSKAPSPLGHDVVTGGNRMPTMPYGKEWRNLRSVVRQITTVPMTASFVPSQEFEAKQLLFDLATDNENQRNFYQHMRRYAFSIIMTNTFGTRVKSWDHPDAQNAVRSQAVLRRTSRPGAFLVDELPPLARLPKXXXXXXXXXXXAAKVETGKAPHCYAREIYESRESWYAKGATEEQLAWVSGGLVEAGFETTAGTLNSLVLYLAANPQVQKTAQEELMRAVGPHRLPTFEDTRRLPYIRACVKEVLRMNPILSPGIRHYADEDVVYKEHVIPKGTVLLANTAYLHYDPRRYKDPQKFMPERYLDHPLYSSDYAAMTDPSRRDHFTFSTGRRTCPGARLAENSLTIALAGMLWAFEIRPGLVDGVETEVDMSDDAYLDTGFTLPKPFAARFLPWSEERLQIVKEQWELASKKGYELRGVPVDIEGMTK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pleosporalin A, ascomycone A, as well as a third cryptic naphthoquinone derived pigment, all responsible for the coloration of conidia (PubMed:28471414, PubMed:35351612).  Involved in the oxidation of fusarubinaldehyde at C-9.  PgmC has low substrate-specificity and is also able to use the pgmA product 3-acetonyl-1,6,8-trihydroxy-2-naphthaldehyde as a substrate (PubMed:35351612).  The pathway begins with the biosynthesis of the cyclized heptaketide 3-acetonyl-1,6,8-trihydroxy-2-naphthaldehyde by the NR-PKS pgmA.  The C-6 hydroxyl group is further methylated by the O-methyltransferase pgmB to yield fusarubinaldehyde which is in turn oxidized by the cytochrome P450 monooxygenase pgmC at C-9.  The C-1 hydroxyl group is then methylated spontaneously.  Although pgmE, pgmD and pgmH are essential for the production of pleosporalin A, it is not the case for the 2 other final products and it remains difficult to assign a specific function to each enzyme.  PgmF and pgmG seem not to be involved in pigment biosynthesis although they were regulated by the cluster-specific transcription factor pgmR (PubMed:35351612) (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase pgmC, Pigmented naphthoquinones biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: KEFF_ECOHS
Sequence: MILIIYAHPYPHHSHANKRMLEQARTLEGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVFSHGWAYGHGGTALHGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefC.  Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefF, Quinone oxidoreductase KefF.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1435_STAEQ
Sequence: METIKKNEVKTGKVIDLTHEGHGVVKVDRYPIFIPNALIDEEIKFKLIKVKKNFAIGKLIEVISESDDRVTPPCIYYAKCGGCQLQHMTYRAQLDMKREQVVNLFHRKGPFENTVIKETIGMVNPWRYRNKSQIPVGQSNSNQVIMGFYRQRSHDIIDMDSCLIQDRQHQEVMNRVKYWLNELNISIYNEKTKTGLIRHLVVRTGYHTDEMMVIFVTNGATFKQSELLVNKLKKEFPNITSIKQNINNSHSNVIMGRQSMTLYGKDKIEDQLSEVTYHISDLSFYQINSSQTEKLYQQALNYAQLTGKEIVLDTYCGIGTIGLYMAPLAKHVYGVEVVPQAIKDAEDNATKNQLKNTTFECGKAEDVILTWKSQGIKPGVVMVDPPRKGCDETFLTTLLKLNPKRIVYISCNPSTQQRDAQILAEQYELVEITPVDMFPQTTHIETVALFVRKDEE
What are the official names of this protein?
Uncharacterized RNA methyltransferase SERP1435.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: ATPB_EQUAR
Sequence: AFENKLMKNYRFLGISTSSEGYITQIIGPVLDVAFPVGKMPNIFNSFIVKGQNPAGQSINVTCEVQQLLGNNKVRAVAMSATDGLMRGMEVIDTGAPLSVPVGEVTLGRIFNVLGEPVDNMGPVEATAKSPIHKPAPAFMDLETTVSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESKVINEENISESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLATEMGCLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTVLQPWIVGEEHYEVAQGVKQTLQRYKELQDIIAILGLDELSEQDRLLVARARKIERFLSQPFFVAEVFTGSPGKYVSLNETIRGFQNDFTGELDSLPEQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: Y209_BRUME
Sequence: MMTALILKRVAQAIPVMLIVAILTFLLMKLLPGDPAILIAGDGASPETVERIRVELGLDQPTVVQLGQWLWNLFHFDLGRSFLLSQPVSQAIAERLPVTISLALLAFAITIPVGIIMGVVAAYLRDSWFDTGVMSLALLGVSVPSFWLAILAVILFSVTLGWFPSAGYVPFLDSPLGWLRSLILPASILALFQIGYLARMTRSEMLEVMDQDYIRTARSKGVSEYSVLSTHAFRNALVSVLTVSGYIFSLLIGGSVVIEQIFALPGLGRLLVQAILARDLPVVQGTMLFLGFLFVAINVLVDILYTIADPRVRYD
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Putative peptide transport system permease protein BMEII0209.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL30_BURM7
Sequence: MSEKTVKVQLVKSLIGTRESHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RL29_STRPF
Sequence: MKLQEIKDFVKELRGLSQEELAKKENELKKELFDLRFQAAAGQLEKTARLDEVKKQIARVKTVQSEMK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: ADEC_ECOLI
Sequence: MNNSINHKFHHISRAEYQELLAVSRGDAVADYIIDNVSILDLINGGEISGPIVIKGRYIAGVGAEYTDAPALQRIDARGATAVPGFIDAHLHIESSMMTPVTFETATLPRGLTTVICDPHEIVNVMGEAGFAWFARCAEQARQNQYLQVSSCVPALEGCDVNGASFTLEQMLAWRDHPQVTGLAEMMDYPGVISGQNALLDKLDAFRHLTLDGHCPGLGGKELNAYITAGIENCHESYQLEEGRRKLQLGMSLMIREGSAARNLNALAPLINEFNSPQCMLCTDDRNPWEIAHEGHIDALIRRLIEQHNVPLHVAYRVASWSTARHFGLNHLGLLAPGKQADIVLLSDARKVTVQQVLVKGEPIDAQTLQAEESARLAQSAPPYGNTIARQPVSASDFALQFTPGKRYRVIDVIHNELITHSHSSVYSENGFDRDDVSFIAVLERYGQRLAPACGLLGGFGLNEGALAATVSHDSHNIVVIGRSAEEMALAVNQVIQDGGGLCVVRNGQVQSHLPLPIAGLMSTDTAQSLAEQIDALKAAARECGPLPDEPFIQMAFLSLPVIPALKLTSQGLFDGEKFAFTTLEVTE
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: EUTK_SALTY
Sequence: MINALGLLEVDGMVAAVDAADAMLKAANVRLLSHQVLDPGRLTLVVEGDLAACRAALDAGSAAAQRTGRVISRKEIGRPEEDTQWLIGGFARATTPTEKAPQVPATPEFAEALLALLASVRQGMTAGEVAAHFGWPLEQARNVLEQLFSDGALRKRSSRYRIKN
What is the function of this protein?
Expression of the eut operon allows this bacteria to use ethanolamine as a carbon, nitrogen and energy source.  It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase (EAL) activity and to induce the operon (PubMed:3045078).  EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
What are the official names of this protein?
Bacterial microcompartment shell protein EutK, Ethanolamine utilization protein EutK.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: VGF_CAMPM
Sequence: MSMKYLMLLFATMIIRSFADSGNAIETTSPEITNTTTDIPAIRLCGPEGDGYCLHGDCIHARDINGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIVLVLVGIIMCCLLSVYRFTRRTNKLPLQDMVVP
What is the function of this protein?
Stimulates cellular proliferation (hyperplasia)and mobility around infected cells to promote rapid and efficient spread of infection.
What are the official names of this protein?
Growth factor, Secreted epidermal growth factor-like.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG019 family.
Protein: CH60_CROS8
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVVAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMEKVGKEGVITVEEGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGDESAIQGRVGQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALVRVAAKLTELTGQNEDQNVGIKVALRAMEAPLRQIVSNAGEEPSVVANNVKAGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYASSVAGLMITTECMVTDLPKEDKADLGAAGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UP08_PSEMZ
Sequence: LQQAEARR
What are the official names of this protein?
Unknown protein 8.
Protein: AMGO3_RAT
Sequence: MAWLVLLGLLLCMLGAGSGTSDLEGVLPPDPHNCPNKCVCAADVLSCAGRGLQDLPAALPATAAELDLSHNALKRLHPGWLAPLSRLRALYLGYNKLDVLGRGVFTNASGLRILDLSSNLLRRLRTYDLDGLEELEKLLLFNNRLMHLDLDAFQGLSMLSHLYLSCNELSSFSFNHLHGLGLTRLRTLDLSSNWLGHVSVPELAALPTFLKNRLYLHNNPLPCDCSLYHLLRRWHQRGLSALHDFEREYTCLAFKVAESRVRFFEHSRVFKNCSVAAAPGLELPEEELHTHVGQSLRLFCNTTVPAARVAWVSPKNELLVAPGSQDGSIAVLADGSLAIGRVQEQHAGLFVCLASGPRLHHNQTLEYNVSVHKPRPEPEAFNTGFTTLLGCIVGLVLVLLYLFAPPCRGCCRCCRRACRNRCWPRASSPLQELSAQSSVLSTTPPDAPSRKASVHKHVAFLEPGKKGLNGRVQLAVAEDFDLCNPMGLQLKAGSESASSTGSEGLMMS
What is the function of this protein?
May mediate heterophilic cell-cell interaction.  May contribute to signal transduction through its intracellular domain.
What are the official names of this protein?
Amphoterin-induced protein 3, AMIGO-3, Alivin-3.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. AMIGO family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: LSM6_YEAS7
Sequence: MSGKASTEGSVTTEFLSDIIGKTVNVKLASGLLYSGRLESIDGFMNVALSSATEHYESNNNKLLNKFNSDVFLRGTQVMYISEQKI
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  In association with PAT1, LSM1-LSM7 binds directly to RNAs near the 3'-end and prefers oligoadenylated RNAs over polyadenylated RNAs.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.  Component of a nucleolar LSM2-LSM7 complex, which associates with the precursor of the RNA component of RNase P (pre-P RNA) and with the small nucleolar RNA (snoRNA) snR5.  It may play a role in the maturation of a subset of nucleolus-associated small RNAs (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=LSM1 and LSM8 act competitively with respect to the localization of LSM1-LSM7 to the cytoplasm and LSM2-LSM8 to the nucleus. LSm proteins shift to the cytoplasm under conditions of stress (By similarity).
Protein: NUOH_LEGPH
Sequence: MLHTIGILIWIIIKILVIVVPLLISVAYLTYAERKVIGYIQVRIGPNRVGLKGLLQPFADLLKLITKEIIVPTRSNKYLFVIAPLFALVPSLVGWAVIPFQEGIVLANINAGVLYLFAMSSLGVYGVLIAGWASNSKYAMFGALRSTAQTVSYEIAMGFALVGVLLAAGSMNLTDIVNSQKGGMLHWWFIPLLPLFLVFWISGIAETNRAPFDLAEGESEIVAGFHVEYSGIGFALFFLSEYASMILISTVLAILFMGGWLSPFEGITFLDQIFFIVPGFVWLLLKISFFLFVYLWVRATFPRYRYDQLMRLGWKVLIPVTIVWLIVTALMVVAHVKPWF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS8_TREPS
Sequence: MGVSDPVADMLTKIRNAARAGHEKVDVPSSKLKVEVVKILKTEGYIRNFRKVEEDGSGCIRVFLKYDDNETSVIHGIERISTPGRRVYSGYKTLRRVYNGYGTLIVSTSLGVTTGRHAREQRVGGELICKVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NUON_SALTO
Sequence: MSMVQTVDNVALLPAYLAAGTAVLVLLADLLVARARVTISVAALGALATAAGAVLVGGGGERRTFCVGADCSYVFGGRAALVAVLVALLTLGVLGLSGPLLRAGATPVGEYCFLLAASMTGGVALGAAGDLITLIVALETLTLPLYVLVGLRRGSLASIEAAVTFFVVSVVATTLTLLGAALLYATTGALHLGRLGALFAERPELLDIPLTTVAVALVVVGLTVKVAAVPFHAWAPTTYDGAPLPVAAYLSTVSKLGGVVALLAVVQHALPAQITGLVLALLAVLTMTVGNLVALRQRRTVRLLAWSSVAQAGYILAPLGALALAAGRTGDARAAAYAAAVAYTVFFVVLELAAFAAVVALRPAGADGGTLDELRGAARRRPWAAVGLALALVGLAGLPPGLAGLFAKVTVVRSLLDGGAAGLALVVAVNAVLGLAYYLRVVAALWSTDRPAVIPTDPTAVPTDPAAAATGPAVGSIDPSVALVRAKPVAVVLAAATVVALVVGFAPQLVLDLAAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KEX1_ASPFC
Sequence: MLLTTPSSRGSRAQSGIANVSWLALSLLLLFSPTLGSAKSAADYYVRSLPGAPEGPLLKMHAGHIEVDAQNNGNLFFWHYQNRHIANRQRTVIWLNGGPGCSSMDGALMEIGPYRLKDNHTLEYNNGSWDEFANLLFVDQPVGTGFSYVNTNSYIHELDEMSAQFITFLEKWFQLFPEYEGDDIYIAGESYAGQHIPYIAKAIQERNNKIQNDQSIRWNLRGIVIGNGWISPAQQYPSYLTFAYEEGLVTKGSSLAKDLEVYQSVCESKISASPNAINIRDCEEILQQILARTKDTNKQCYNMYDVRLRDTYPSCGMNWPTDLVDVKPYLQRPDVVQALNINPEKKSGWEECSGAVSSTFNAANSLPSVQLLPELLESGIPILLFSGDKDLICNHVGTEQLINNMKWNGGTGFETSPGVWAPRHDWTFEGEPAGIYQYARNLTYVLFYNASHMVPYDLPRQSRDMLDRFMKVDIANIGGKPADSRIDGEKLPQTSVGGHPNSTAAEQQAKEKIKETEWKAYAKSGEAALIVVIIGVTVWGFFIWRSRRRNRGYQGVYQRDIGSGSILERFHNKRSGPADVEAGDFDESELDNLHSPGLEQEHYAVGDDSDEESPNHQPAAPPSSTKPGGAQP
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase kex1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: M2_I81A2
Sequence: MSLLTEVETPTRNGWECKCSDSSDPLVIAASIIGILHLILWILDRLFFKFIYRRLKYGLKRGPSTEGVPESMREEYRQEQQNAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: RR4_JASNU
Sequence: MPRYLGPRFKKIRRLGALPGLTNKSPKAGSDLRKQPRSRKKSQYRIRLEEKQKLCFHYGLREYQLLNYVRIAAKAKGPTGQVLLQLLEMRLDNILFRLGMASTIPAARQLVNHRHILVNGRIVDRPSYRCKPRDIIMTKDNQKSRTLIQNSLGSSPQKELPNHLTLHPFQYKGLVNQIIDSKWVGLKINELLVVEYYSRQTKA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MTDTR_PSEAE
Sequence: MTNYLYLAIAIAAEVVATTSLKAVAGFSKPLPLLLVVGGYVLAFSMLVLVMRTLPVGVVYAIWSGLGIVLVSLVAMFVYGQRLDPAALLGIGLIIAGVLVIQLFSRASGH
What is the function of this protein?
Confers resistance to ethidium bromide, acriflavine and methyl viologen.
What are the official names of this protein?
Multidrug transporter PA4990.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRI4_STRRG
Sequence: MTTPQIDERAMEAGAAALQETIVDPGPLDVTALAVAAALAAGLHSAADDPAAALDKCIVLDELTEFAEKLVVHDRPGGIGTTVEYVEVYEDASGVRLGTATGNAVVLKMEPHMWQFHQSVSELADGSFEAVGVIDCTAMLRRMTQVLRVTGRSGRYAGKSGFMTLAISDPNQRPPHYSVQVVLC
What is the function of this protein?
Involved in the biosynthesis of the spirotetramate antibiotics pyrroindomycins.  Catalyzes the intramolecular cyclization forming the spiro-conjugate moiety in pyrroindomycins, via an exo-selective [4+2] cycloaddition reaction.
What are the official names of this protein?
Spiro-conjugate synthase, [4+2] cyclase PyrI4.
Protein: BHMT1_PONAB
Sequence: MPPVVGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQKVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNMGIRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSALDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKLQ
What is the function of this protein?
Involved in the regulation of homocysteine metabolism.  Converts betaine and homocysteine to dimethylglycine and methionine, respectively.  This reaction is also required for the irreversible oxidation of choline.
What are the official names of this protein?
Betaine--homocysteine S-methyltransferase 1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress.
Protein: RNT_BUCBP
Sequence: MCYSKINNSLRKRFRTFYPVVIDIETAGFNPETDAILEIAIITLKMNEFGLLEKEHLLHFHIQPFKGSRIDKKAIEFHGIDPFSPLRRAISEYEALYSIFNLIHKGIKSNNCTKSIIVAHNAIFDYNFLTAAITRTKIKNNPFHSFVIFDTATLSGLAVGQTVLARACKAIGLTFDNNQAHSALYDTQQTANLFCKIVNRWKTLGGWPPNDTRTIKL
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.