PharMolix/UniProtQA huggingface dataset:
Protein: FLIR_SALTY
Sequence: MIQVTSEQWLYWLHLYFWPLLRVLALISTAPILSERAIPKRVKLGLGIMITLVIAPSLPANDTPLFSIAALWLAMQQILIGIALGFTMQFAFAAVRTAGEFIGLQMGLSFATFVDPGSHLNMPVLARIMDMLAMLLFLTFNGHLWLISLLVDTFHTLPIGSNPVNSNAFMALARAGGLIFLNGLMLALPVITLLLTLNLALGLLNRMAPQLSIFVIGFPLTLTVGIMLMAALMPLIAPFCEHLFSEIFNLLADIVSEMPINNNP
What is the function of this protein?
Role in flagellar biosynthesis.
What are the official names of this protein?
Flagellar biosynthetic protein FliR.
What is the protein family that this protein belongs to?
Belongs to the FliR/MopE/SpaR family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: MINE_PHOLL
Sequence: MALLDFFLSRKKTTANIAKERLQIIVAERRRGDSEPAYLPDMKRDILAVICKYIQVDPDMLSVQFEQKGDDISVLELNITLPEAEETQK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: IL1B_CANLF
Sequence: MAAVPELTSEMMAYSSNNENDLFFEADGPGNDVKCCCQDLNHSSLVDEGIQLQVSHQLCNKSLRHFVSVIVALEKLKKPCPQVLQEDDLKSIFCYIFEEEPIICKTDADNFMSDAAMQSVDCKLQDISHKYLVLSNSYELRALHLNGENVNKQVVFHMSFVHGDESNNKIPVVLGIKQKNLYLSCVMKDGKPTLQLEKVDPKVYPKRKMEKRFVFNKIEIKNTVEFESSQYPNWYISTSQVEGMPVFLGNTRGGQDITDFTMEFSS
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: T23O_DROAN
Sequence: MSCPYAGSGNDHDDAAVPLSTEVGKIYGEYLMLDKLLDAQCMLSKEDKRPVHDEHLFIITHQAYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQKYSDVFGGDEDALTAIRSSEQEPSLLELVQRWLERTPGLEESGFNFWEKFQQSVDKFLEAQVHSAMEEPVERAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDESIRKKLINKSV
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Protein vermilion, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: YTFE_ECO27
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVDVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMEHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNE_PSEA8
Sequence: MSAALLLATLLMTGLGQVAQKLTVEHWRLVAADGWTARLRSPWPWLALLALGLGLLCWLLLLQRVEVGSAYPMLALNFVLVTLAARFVFDEPVDRRHLAGLLLIVAGVALLGRSA
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE, L-Ara4N-phosphoundecaprenol flippase subunit ArnE, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE.
What is the protein family that this protein belongs to?
Belongs to the ArnE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPF_HERA2
Sequence: MDKLGVDLPLLISQIVNFCLLAFLLNTFLYKPVLNALQARSERIRESLDNAEKVKQQLARVDADYEAKLQEARREGQTIISQAQERARAQEAELLVVARNNAAKIEEEARGKVEQERQQVLRGLQGQLASLVTETASNVLGRELQTKGHDELINKSIDQLGRLN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GLPE_VIBCH
Sequence: MDHFLHIDVNAAQAMMEQKQAHLVDIRDPQSFQLAHAKNAYHLTNQSMVQFMEQAEFDQPVLVMCYHGISSQGAAQYLVNQGFEEVYSVDGGFEAWHRANLPIEAS
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMC_SALTY
Sequence: MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARFECAASRAHTQQFHHWQVLSRQMGDNVRFSLVAQASDVADCDTLIYYWPKNKPEAQFQLMNILSLMPSGVDVFVVGENRSGVRSAEPMLADYAPLNKVDSARRCGLYHGRLEKQPQFSLESWWAEYNIDGLTIKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSAALASHSPKVRLTLCDVSAPAVEASRATLAANGLEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPKILDETFGFHEVIAQTGRFKVYRTVMTRQAKK
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALGF_PSEAE
Sequence: MNPMTRRHTWTRLACALSLGVAAFAAQADEGALYGPQAPKGSAFVRAYNAGNSELDVSVGSTSLNDVAPLGSSDFKFLPPGSYTAQVGQQSLPVKLDPDSYYTLVSQPGGKPQLVAEPPFKNKQKALVRVQNLSGSKLTLKTADGKTDVVKDVGPQSHGDREINPVKVNLALFDGSKKVSDLKPVTLARGEVVCLYVTGSGGKLAPVWVKRPVKAD
What is the function of this protein?
Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues.  Acetylation of alginate is important for the architecture of biofilms and increases resistance to opsonic killing in the host.
What are the official names of this protein?
Alginate biosynthesis protein AlgF.
What is the protein family that this protein belongs to?
Belongs to the AlgF family.
What are the subcellular locations of this protein?
Periplasm.
Protein: KEX1_CLAL4
Sequence: MIVRLFWLAVLWLALANANPLKRLNHVWSQRGVAKDDFLVTSLPGLSENIASDDVPLMFAGQLELYPENNTHYFFWKFSDQKKEPEAANRTIFWLNGGPGCSSMDGALMEAGPLRIGKDYKVQLNEGSWHRKGDVVFVDQPAGTGFSYSRDYDVELYQIEYHFLQFLKKYFELFPEDAHNDIVLAGESYAGQYIPYIAHGILERNKKLADGESPYHLKGLAIGNGWISPNEQSLSFVPFAVQAGLVSQKDPGWKAILQQHMKCQDLVAASHEDDTFGANSVVDKECEKVLNTILYELVDHSASQYEQCINMYDYTLRDSFPSCGMNWPPDLSNVNHFLKSDEVMSSLNLVQQISWTECSEHVGKQMKARHSKPAITLFADLLAEVEILLFHGNRDIICNYMGAESMIKKLHWGGQTGFSADSPVLKWFHGDEEAGYVKSERNLTFVNVFDASHMVPFDKPEVSSALVDILFKRFTVADDKLQTQAKKTNANQNDSPSASENDNESGRTSESASSSPSESAATETESHATRIVRLIQLAVIIILIWGLCAIYSTYRSKPTSIIKTKPSGRKKNVQWADLMPQEEPAPKGFLSKTLNKLSRTEHKYVPVDIELGPTDGMDDASSDSGPSNVGTAETPEFVIASDDEENAHEHTEEH
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: TATB_SHIFL
Sequence: MFDIGFSELLLVFIIGLVVLGPQRLPVAVKTVAGWIRALRSLATTVQNELTQELKLQEFQDSLKKVEKASLTNLTPELKASMDELRQAAESMKRSYVANDPEKASDEAHTIHNPVVKDNEAAHEGVTPAAAQTQASSPEQKPETTPEPVVKPAADAEPKTAAPSPSSSDKP
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NHAB_ESCF3
Sequence: MEISWGRALWRNFLGQSPDWYKLALLIFLIINPLIFLVNPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVMIGMTSPSHVRAEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKALLSLSFCLAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRGEDNDILDDSHIDQHFKVILEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWSFGDFFLRMSPITVPVLVCGLLTCLLVERMGWFGYGEKLPEKVRQVLQQYDDQSRLQRTRQDKVRLIVQALIGIWLVIALALHLAEVGLIGLSVIIMATSLTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQSLFSPIIHFVLQASEHAQLTLFYLFNGLLSSISDNVFVGTIYINEAKAAMENGTISLNQFELLAAAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTCVGLLCVEFTLAPMTEWMTQQGWLATLS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDXJ_BACTN
Sequence: MTKLSVNINKVATLRNARGGDTPNVVKVALDCEAFGADGITVHPRPDERHIRRADVYDLRPLLRTEFNIEGYPSPEFIDLVLKVKPHQVTLVPDDPSQITSNSGWDTKANLEFLSEVLDQFNSAGIRTSVFVAADPEMVEYAAKAGADRVELYTEPYATAYPKNPEAAVAPFVEAAKTARKLGIGLNAGHDLSLVNLNYFYKNIPWVDEVSIGHALISDALYLGLERTIQEYKNCLR
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_XANOM
Sequence: MSSSTSTIVAIASAAGTGGVGIVRLSGPQSRQIAVQLGVARLQPRHAHYARFRDAQGAVIDDGIALWFNAPHSFTGEDVVELQGHGSPVLLRQLVARCIELGARQARAGEFSERAFLNGKLDLAQAEAIADVIAAGDLRAARAARRALDGVFSRRVDAVAHTLTRLRIHVEAAIDFADEPLDTLGGNQVRDGLTQARTLLAQLLRDAERGRTLRDGLHAVLIGPPNAGKSSLLNALAGSERAIVTDVAGTTRDTLHEAIQLDGFELTLVDTAGLRDGGDAIEREGMRRARAELERADLALVVLDARDPQAARAAIGDAIDAVPRQLWIHNKCDLLSDAAPLDVNAIAVSAVTGQGLEQLHIRLRELALGDGVEGVDGEFSARTRHVEALRRAERHVDAADLELGFEQLELAAEELRLAHEALGEITGKISADDLLGKIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIO_PEPAC
Sequence: MSALLVEIDKDQFQAEVLEAEGYVLVDYFSDGCVPCKALMPDVEELAAKYEGKVAFRKFNTSSARRLAISQKILGLPTITLYKGGQKVEEVTKDDATRENIDAMIAKHVG
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: LIMA_RHOER
Sequence: MTSKIEQPRWASKDSAAGAASTPDEKIVLEFMDALTSNDAAKLIEYFAEDTMYQNMPLPPAYGRDAVEQTLAGLFTVMSIDAVETFHIGSSNGLVYTERVDVLRALPTGKSYNLSILGVFQLTEGKITGWRDYFDLREFEEAVDLPLRG
What is the function of this protein?
Catalyzes the conversion of limonene-1,2-epoxide to limonene-1,2-diol.  Can use both the (-) and (+) isomers of limonene-1,2-epoxide as substrates and also has some activity with 1-methylcyclohexene oxide, cyclohexene oxide and indene oxide as substrates.
What are the official names of this protein?
Limonene-1,2-epoxide hydrolase.
What is the protein family that this protein belongs to?
Belongs to the limonene-1,2-epoxide hydrolase family.
Protein: ATPD_BURVG
Sequence: MAELATIARPYAEALFRVAEGGDIAAWSTLVQELAQVAHLPEVLSVASSPKVTRKQVAELLLVAVKSPLAAGAEAKNFVQMLVDNHRIALLPEIAEQFEALKNEREGAADAEIVSAFPLEGAELDSLVSGLERKFKRKLKPTVEVDSSLIGGVRVTVGDEVLDTSVRARLASMQAALTA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CH60C_DROME
Sequence: MMRMFRYTNTLQRTAKISHVLWARNYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGRDGVITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPALELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQKLNDLKGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGDYGYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEEAAAAGAAAGLGALGGMGMGGMGM
What is the function of this protein?
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).  Essential for proper development of trachea, spermatogonia and spermatocytes.
What are the official names of this protein?
60 kDa heat shock protein homolog 2, mitochondrial, 60 kDa chaperonin, CPN60, Heat shock protein 60, HSP-60, Hsp60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GATA_RHOE4
Sequence: MTDLTTLDAAELAGKIHSREVSSVEVTQAHLDRIAAVDTEYHAFLHVAGEQALEAAAAVDNSLAGGNEPASALAGVPIALKDIFTTTDMPTTCASKILEGWVAPYDATLTSKLRAAGIPILGKTNLDEFAMGSSTENSAFGPTRNPWDVTRIPGGSGGGSAAALASRQAPLAIGTDTGGSIRQPAAVTATVGTKPTYGTVSRFGLVACASSLDQGGPCGRTVLDTALLHEVIAGHDPRDSTSIDAPVRPVVAAAREGAAGDLRGVKVGVVKELHSDSYQPGVIASFDAAVEQLKALGAEVVEVSCPSFEHALASYYLVLPSEVSSNLARFDAMRYGLRVDEGNMSADQVMAATRAAGFGPEVKRRIMIGTYALSSGYYDAYYGSALKVRTLIARDFDKAYEKVDVLVSPTSPFTPWKLGEKVGDPLAMYLSDLCTLPTNLAGHCAMSVPSGLSADDNLPVGLQIMAPAMADERLYRVGAAYEAARGPIATAV
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: CU042_HUMAN
Sequence: MFSLFIENRYLHLLHALSLVTDVSRIQSHFGTLPRIKDEHRSHQESKYHFGGHVQIRFGSDQDWRQGHQSFLLKTGPCKKR
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC00158.
Protein: ALG8_SCHPO
Sequence: MGKLSMLYNAAIASTFVKVFLFPSYRSTDFEVHRNWLAITHSLPISEWYKSSISEWTLDYPPFFAYMECVLSWIAYFFGFDKAMLDPYNLNYVSPSTVVFQRGSVIVLELVLLFALREYVLSSNVKDQRNALLTAIDIFLSPGLLIIDHIHFQYNGFLFGLLLWSIVLAKPEKNMLLSAAIFSALICFKHIFLYVAPAYFVYLLRVYCFTPNFRPQFLNILKLGSTVISIFLLAFGPWIYMKQIPQLLSRLFPFSRGLCHAYWAPNFWALYSFVDRVAFAVLPRFGYALNQGTSINAPTRGLVGESSFAVLPNIPPALTFYICLGLQITVLIKLFIKPTWRVFVGAVTLCGWISFLFGWHVHEKAILMVILPFSILSLIDRRYLEAFRPLAVSGYLSLLPLLFTLNEAPIKYLFTGAWIAMLLTFDKCAPVPVKRVFLLNRVNIAYISGFVPLFIYNCFIHKLVMGDKFEFLPLMLLSTYAAWGIFWSFVSLLWLYFTDLK
What is the function of this protein?
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
What are the official names of this protein?
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 8, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG6/ALG8 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PRDM6_BOVIN
Sequence: MLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGGGPLKGGGAAGPLGAPQPLQPPPPPERAEPQPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAAAAALAGLSALPVAQLPVFAPLATVAAEPLPPKDLCLGATSGPGPSKCGGSGGDGRGVPRFRCSAEELDYYLYGQQRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHGPLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQDGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENLNVPSTVMEAMCRQDALQPFNKSSKLSQAPQQRSVVFPQTPCGRNFSLLDKSGPLESGFNQISVKNQRVLASPTSTSQLHSEFSDWHLWKCGQCFKTFTQRILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVVTHSSDRPFKCGYCGRAFAGATTLNNHIRTHTGEKPFKCERCERSFTQATQLSRHQRMPNECKPITESPESIEVD
What is the function of this protein?
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression.  Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells.  Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation.  It is unclear whether it has histone methyltransferase activity in vivo.  According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a.  According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro.  'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression.
What are the official names of this protein?
Putative histone-lysine N-methyltransferase PRDM6, PR domain zinc finger protein 6, PR domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLPK_BACCN
Sequence: METYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQYFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITNQRETAVVWEKATGKPVYNAIVWQSRQTAEICEELKEKGYGDMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAERGELLFGTIDTWLVWKLSGGKAHVTDYSNASRTLMFNIHDLKWDDELLEILTVPKSMLPEVRPSSEVYGHTVDYHFFSQNVPIAGVAGDQQAALFGQACFSEGMAKNTYGTGCFMLMNTGETAVNSNHGLLTTIAWGLNGKVNYALEGSIFVAGSAIQWLRDGMRMVNDASESEEYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAVFGVTRGTTKEHFIRATLESLGYQTRDVLCAMEADSGIELKTLRVDGGAVKNNFLMQFQSDMLQVPVERPMISETTALGAAYLAGLAVGYWESQEEIKAQWDMDRSFTPEMEKERSEELYSGWKKAIEATKAFK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: HRP3_SCHPO
Sequence: MSTSAIALALSSSKAIEQLDHVQTETPNLKQEMSESPSNSGVASKRKLQSTEWLDPELYGLRRSGRTRSNPGRYVDTDDQEDVFPSKHRKGTRNGSSFSRHRTIRDLDDEAESVTSEESESDDSSYGGTPKKRSRQKKSNTYVQDEIRFSSRNSKGVNYNEDAYFESFEEEEEEEMYEYATEVSEEPEDTRAIDVVLDHRLIEGHDGSTPSEDYEFLIKWVNFSHLHCTWEPYNNISMIRGSKKVDNHIKQVILLDREIREDPTTTREDIEAMDIEKERKRENYEEYKQVDRIVAKHLNSDGSVEYLVKWKQLLYDFCTWEASSIIEPIAATEIQAFQEREESALSPSRGTNYGNSRPKYRKLEQQPSYITGGELRDFQLTGVNWMAYLWHKNENGILADEMGLGKTVQTVAFLSYLAHSLRQHGPFLVVVPLSTVPAWQETLALWASDMNCISYLGNTTSRQVIRDYEFYVDGTQKIKFNLLLTTYEYVLKDRSVLSNIKWQYMAIDEAHRLKNSESSLYEALSQFKNSNRLLITGTPLQNNIRELAALVDFLMPGKFEIREEINLEAPDEEQEAYIRSLQEHLQPYILRRLKKDVEKSLPSKSERILRVELSDLQMYWYKNILTRNYRVLTQSISSGSQISLLNIVVELKKASNHPYLFDGVEESWMQKINSQGRRDEVLKGLIMNSGKMVLLDKLLSRLRRDGHRVLIFSQMVRMLDILGDYLSLRGYPHQRLDGTVPAAVRRTSIDHFNAPNSPDFVFLLSTRAGGLGINLMTADTVIIFDSDWNPQADLQAMARAHRIGQKNHVMVYRLLSKDTIEEDVLERARRKMILEYAIISLGVTDKQKNSKNDKFSAEELSAILKFGASNMFKAENNQKKLEDMNLDEILEHAEDHDTSNDVGGASMGGEEFLKQFEVTDYKADVSWDDIIPLTEREKFEEEDRLREEEEALKQEIELSSRRGNRPYPSSAVESPSYSGTSERKSKKQMLKDEVLLEKEIRLLYRAMIRYGSLEHRYNDIVKYADLTTQDAHVIKKIAADLVTASRKAVSAAEKDLSNDQSNNKSSRKALLITFKGVKNINAETLVQRLNDLDILYDAMPTSGYSNFQIPMHVRSVHGWSCQWGPREDSMLLSGICKHGFGAWLEIRDDPELKMKDKIFLEDTKQTDNSVPKDKENKEKKVPSAVHLVRRGEYLLSALREHHQNFGIKSSPAISTNGKTQPKKQTANRRQSGKPNVKSAQKIESATRTPSPAISESRKKPSSKDTKIETPSREQSRSQTASPVKSEKDDGNVSLNAEQKARCKELMYPVRKHMKRLRKDSSGLGRAELVKLLTECLTTIGKHIEKTVNDTPSEEKATVRKNLWMFACYFWPKEEVKYTSLISMYEKMK
What is the function of this protein?
Involved in heterochromatin silencing.  Required for transcriptional repression at the silence loci of mat3, where it has a direct role as a chromatin remodeling factor.
What are the official names of this protein?
Chromodomain helicase hrp3, ATP-dependent helicase hrp3.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TUSB_SALHS
Sequence: MLHTLPHCASSVDFPALLRLLKEGDALLLLQDGVTVAIEGNRFLESLRDAPITVYALKEDIDARGLGGQISDSVVRVDYTEFVRLTVKYANQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.