PharMolix/UniProtQA huggingface dataset:
Protein: IKIT_PARTR
Sequence: ADVPGNYPLDKDGNTYKCFLLGENEECLNVCKLHGVQYGYCYASKCWCEYLEDDKDSV
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  Does not produce effect when administered to blowfly and cabbage looper larvae.  In mice, does not produce convulsions, tremors, increased ventilation nor death.
What are the official names of this protein?
Ikitoxin.
What is the protein family that this protein belongs to?
Belongs to the long (3 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR8_HELPY
Sequence: MLERYANEEMKALWNEQTKFETYLEVEKAVVRAWNKLGQIQDSDCEKICAKAAFNLERIKEIEKTTKHDLIAFTTCVAESLGEESRFFHYGITSSDCIDTAMALLMTKSLKLIQKGVKNLYETLKNRALEHKDTLMVGRSHGVFGEPITFGLVLALFADEIKRHLKALDLTMEFISVGAISGAMGNFAHAPLELEELACEFLGLKTANISNQVIQRDRYARLACDLALLASSCEKIAVNIRHLQRSEVYEVEEAFSTGQKGSSAMPHKRNPILSENITGLCRVIRSFTTPMLENVALWHERDMSHSSVERFALPDLFITSDFMLSRLNSVIKNLVVYPKNMLKNLALSGGLVFSQRVLLELPKKGLSREESYSIVQENAMKIWEVLQQGAFKNTDENLFLNALLNDERLKKYLSEDEIKACFDYNYYTKNVGAIFKRVFE
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: SYW_HALH5
Sequence: MKKTVFSGIQPSGTLTLGNYLGAMKHFVSLQEDYNCYFCIVDQHAITVPQDRLKLRENIRSLAALYLAVGIDPSKATLFIQSEVPAHAQLGWMMQCVSYIGELERMTQFKDKSDGKEAVSASLLTYPPLMAADILLYHTNIVPVGEDQKQHLELTRDLAERFNKKYNDIFTIPEVQIPKVGARIMSLNDPSKKMSKSNPNPKSYISMLDDEKTITKKIKSAVTDSDGIVKFDKENKPAISNLLSIYSLCKGASIEEVEAQFVGKGYGEFKESLAQVVVDTLKPIQERYEQLIQSEELDHILDQGADKANRVARKTLEKAERAMGLGRKRR
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein: GREB_VIBVY
Sequence: MKTKMITREGYNKLKQELDYLWKEHRPEITQKVSWAASLGDRSENADYTYNKRLLRQIDRRVRFLSKFLPEVKIVDYAPQQEGKVFFGAWVEIENEAGEVMKFRIVGPEEIYGDAKGYISIDSPMARALLKKEVDDEVQVPTPSGIKEWFINSIEYDKGQ
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreB releases sequences of up to 9 nucleotides in length.
What are the official names of this protein?
Transcription elongation factor GreB, Transcript cleavage factor GreB.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family. GreB subfamily.
Protein: DNAA_RICAE
Sequence: MSTNQIILTDQGNNYVNVWSHVAQDLYNHYGETLYNSWFSKVNFIESSLNTVILCAPTNFVRDWIKSKYSMVILQLFQHYNNTIKSIEIITKELPGTTQTVTELPTKTFADIGSSELNSENIFSTLDVRFTFDNFVVGAPNELAYAAARAVAESSGAVSESNPLFLYGGVGLGKTHLMHAIGWYIKQHNPSRKVIYMSAEKFMYQFVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLIDNNRQMVISCDRSPSDLDNIEDRIKSRLGWGLVADVHSTTYELRLGILESKIEQMNVKIPKDVIDFLASKIVSNVRELEGALNKVIAHSNFTLKEITLENTQNILRDLLRSNERIITVEDIQKKVASRYNIKLSDMSSSRRLREVARPRQIAMYLSKALTPKSLADIGKKFGKKDHTTVMHAIKKVEELLENDIELREEIHLLMKILQN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_SYNR3
Sequence: MLAVAVLAAGKGTRMKSNLPKVLQPLAGATLVERVLASARNLRPERRLLIVGHQAERVEQQLSAVDGLEFVLQQPQNGTGHAVQQLLDPLANFEGELLVLNGDVPLLRAETIDQLVSTHRSSGAQVTLLTARLDDPTGYGRVFADEQGAVSSIIEHRDCSEEQRRNNLTNAGIYCFNWTALAEVLPKLSTDNDQGELYLTDTVAMLTKAMHVEVADPDEVNGINNRQQLAQCETMLQERLRHHWMAEGVTFVDPASCTLSEGCQFGRDVVIEPQTHLRGRCQIGDESRLGPGSLIEDAELGRGVTVVMSVVREASVGDGVCIGPFAHLRPAAVIGNNCRIGNFVEVKKSTVGEASKVNHLSYIGDAELGASVNVGAGTITANYDGVNKHRTVIGDGSKTGANSVLVAPIQLGNKVTVAAGSTLTKNVPDGALALGRAKQLIKENWAGPQG
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRCA_SHIDS
Sequence: MITGIQITKAANDDLLNSFWLLDSEKDEARCIVAKAGFAEDEVVAVSKLGDIEYREVPVEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: CTPAL_STAAM
Sequence: MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTTLITAVITVVAYIFINQKISGLNKTDQANLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLTKEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIKGKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVDYKKKGKVGVITINKFQNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKDTEAIQTSNDSLKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTTREFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKNIKTIKIGLSALGYKVDNESTQFDQALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEKANKHDDVLDKLINILK
What are the official names of this protein?
Probable CtpA-like serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S41A family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: PCP_MYCBP
Sequence: MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNTFFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVLVGEPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQKGLPVRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCG1_BOVIN
Sequence: MQPAALLGLLGATVVAAVSSMPVDIRNHNEEVVTHCIIEVLSNALLKSSAPPITPECRQVLKKNGKELKNEEKSENENTRFEVRLLRDPADTSEAPGLSSREDSGEGDAQVPTVADTESGGHSRERAGEPPGSQVAKEAKTRYSKSEGQNREEEMVKYQKRERGEVGSEERLSEGPGKAQTAFLNQRNQTPAKKEELVSRYDTQSARGLEKSHSRERSSQESGEETKSQENWPQELQRHPEGQEAPGESEEDASPEVDKRHSRPRHHHGRSRPDRSSQEGNPPLEEESHVGTGNSDEEKARHPAHFRALEEGAEYGEEVRRHSAAQAPGDLQGARFGGRGRGEHQALRRPSEESLEQENKRHGLSPDLNMAQGYSEESEEERGPAPGPSYRARGGEAAAYSTLGQTDEKRFLGETHHRVQESQRDKARRRLPGELRNYLDYGEEKGEEAARGKWQPQGDPRDADENREEARLRGKQYAPHHITEKRLGELLNPFYDPSQWKSSRFERKDPMDDSFLEGEEENGLTLNEKNFFPEYNYDWWEKKPFEEDVNWGYEKRNPVPKLDLKRQYDRVAELDQLLHYRKKSAEFPDFYDSEEQMSPQHTAENEEEKAGQGVLTEEEEKELENLAAMDLELQKIAEKFSGTRRG
What is the function of this protein?
Secretolytin has antibacterial activity.
What are the official names of this protein?
Secretogranin-1, Chromogranin-B, CgB, Secretogranin I, SgI.
What is the protein family that this protein belongs to?
Belongs to the chromogranin/secretogranin protein family.
What are the subcellular locations of this protein?
[Secretogranin-1]: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Lumenal side. Note=Neuroendocrine and endocrine secretory granules. Found to be membrane bound inside the secretory vesicles. The N-terminal region exhibits pH-dependent membrane-binding activity, binds to the membrane at intravesicular pH (5.5) and freed when the pH is near to physiological pH. SUBCELLULAR LOCATION: [Peptide BAM-1745]: Secreted. SUBCELLULAR LOCATION: [Secretolytin]: Secreted.
Protein: SYGB_SHIF8
Sequence: MSEKTFLVEIGTEELPPKALRSLAESFAANFTAELDNAGLAHGTVQWFAAPRRLALKVANLAEAQPDREIEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLTTDKGEWLLYRAHVKGESTEALLPNMVATSLAKLPIPKLMRWGASDVHFVRPVHTVTLLLGDKVIPATILGIQSDRVIRGHRFMGEPEFTIDNADQYPEILRERGKVIADYEERKAKIKADAEEAARKIGGNADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPAEALVYTMKGDQKYFPVYANDGKLLPNFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFNTDRKKRLEDNLPRLQTVLFQQQLGTLRDKTDRIQALAGWIAEQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLNLDLQTLTEEAVRLYGDKLTNANVVDDVIDFMLGRFRAWYQDEGYTVDTIQAVLARRPTRPADFDARMKAVSHFRTLEAAAALAAANKRVSNILAKSDEVLSDRVNASTLKEPEEIKLAMQVVVLRDKLEPYFAEGRYQDALVELAELREPVDAFFDKVMVMVDDKELRLNRLTMLEKLRELFLRVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIFK_AERPE
Sequence: MDCGVFEGTVFSGLGHGSFYVSIYARNLRRALGYTPYPGTLNLRVGDAAERLAGCIERARGVRIEPPPIPGERLASVLAFPVEIEGGVRGHIVRPEITVYKGDVVEIVADVYLRDVLKISDGDKVRFRLLDP
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: YCF27_PORPU
Sequence: MENQKEKILVVDDEASIRRILETRLTIIGYEVITASNGEEALIIFRKEYPSLVVLDVMMPKLDGYGVCQELRKESDVPIIMLTALGEVCDRITGLEIGADDYVVKPFSPKELEARIRSVLRRADKITTNLGVPNSGIISIGFLKIDTNKRQVYKNNERVRLTGMEFSLLELLVSKAGEPFSRASILQEVWGYTPERHVDTRVVDVHISRLRAKLEDDPSNPDLILTARGTGYLFQRIIEMNKL
What is the function of this protein?
Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase.
What are the official names of this protein?
Probable transcriptional regulator ycf27, OmpR-like protein.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GSHB_YERPE
Sequence: MIKLGIVMDPISSINIKKDTSFAMLLEAQRRGWELHYMEMGDLYMRGGDGRARTRRLNVKQDKDNWFSFGAEQDLPLYDLDVILMRKDPPFDTEFIYATYILERAEDKGTLVVNKPQSLRDCNEKLFTAWFPELTPDTLVSRSKDHIRKFHQEHGDIILKPLDGMGGTSIFRVKQDDPNLSVIIETLTELSSRFCMAQNFLPAIKEGDKRVLVVDGEPVPYCLARIPAQGETRGNLAAGGRGEARPLSESDWEIARTVAPILKQKGLIFVGLDIIGDRLTEINVTSPTCVREIEAAFPEISITGMLMDAIERRLADKKA
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, GSHase, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic GSH synthase family.
Protein: PYRH_ANAMM
Sequence: MSVSDGAATGSVRYSRVLLKVSGEAFVGEKRFGFDPAVVLRLSRDLKNVKESGVELCIVVGGGNIFRGASTSDGFERTSNDYVGMLATVINALALQNALEEMGVECRVLSAMPMTAVCETYVRRRAVRHLEKGRVVICAAGIGSPFFTTDTAAALRGIEMRCDAIFKGTQVDGVYSSDPKKDGSAVRYDRISYHDLLSSNLKIMDAAAISLARENSVPIIVFDLGRDGAFFEAVHGRGLFTTISD
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCS3_SCHPO
Sequence: MTEKTASHYWNEETSILKLRRKDILLFEIYATTLLLGSIYSIYVDKWSITSYFGNSKNLINLIFVKRGWFWTSLVYFYHAWDQKRNKIDFKFISRYIVATLWWMFVTQWFIGPGLIDRTFALSGGSCKNFDGDSSVFIPLTASTCKGLNGSWSGGHDLSGHVFLLTHSSLFMLSENFSFILNNGIKATSTKVLFGLLGLWWWMLFVTASFYHTTFEKCTGFFSGILEWSIVYVFSSRMPAVADLLGSSDY
What is the function of this protein?
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity).  Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity).  This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity).  May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity).  May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity).  May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
What are the official names of this protein?
Acyl-coenzyme A diphosphatase fit1, Acyl-coenzyme A diphosphatase scs3, FIT family protein scs3.
What is the protein family that this protein belongs to?
Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.
Protein: ST7_ATEGE
Sequence: MAEAGTGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAMIDIFCSAEFRDWNCKSIFMRVEDELEIPPAPQSQHFQN
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CA1C_CONCT
Sequence: ASGADTCCSNPACQVQHSDLC
What is the function of this protein?
Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them.  This toxin selectively inhibits alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=3. 51 uM) and alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=0. 94 uM) nAChRs.
What are the official names of this protein?
Alpha-conotoxin CIC, C1.1, Ca001.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ENK24_HUMAN
Sequence: MVTPVTWMDNPIEVYVNDSEWVPGPTDDRCPAKPEEEGMMINISIGYRYPPICLGTAPGCLMPAVQNWLVEVPIVSPISRFTYHMVSGMSLRPRVNYLQDFPYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDKHKHKKLQSFYPWEWGEKGISTPRPKIISPVSGPEHPELWRLTVASHHIRIWSGNQTLETRDRKPFYTVDLNSSLTLPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNWQHRILLVRAREGVWILVSMDRPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIAVTATGAVAGVALHSSVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSDFCITPQIYNESEHHWDMVRHHLQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQLRRDSDHRERAMMTMAVLSKRKGGNVGKSKRDQIVTVSV
What is the function of this protein?
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain.  The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
What are the official names of this protein?
Endogenous retrovirus group K member 24 Env polyprotein, Envelope polyprotein, HERV-K101 envelope protein, HERV-K_22q11.21 provirus ancestral Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.
What are the subcellular locations of this protein?
[Transmembrane protein]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Surface protein]: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. SUBCELLULAR LOCATION: [Endogenous retrovirus group K member 24 Env polyprotein]: Virion.
Protein: WUHO_CULQU
Sequence: MSSFIKRFRKSTLVAFNRTVHFLQDDYSVWSYEIDADKESVPFEKGRPRKYFDADSDSDEEQQNGDEPGTGKNNGGGDTGKKDQDDQTNAIVALDVNEDRSLVAVATGDKSLYLFEVDQDGRTLKVLSRRLLSRASSCVKFAAGGRFAIVCDKGGDCYKYDCEEYRKPGRWLLGHMSQVLDVLIDTEEKLIITSDRDEKIRVTCHPDCHNIETFCLGHTEFVSHLEFLGPELLLSLSGDKTLRWWNYTSGKELARKELELPGNKLALQKLAADGTGLLAVLCYKPTAVNVFKLSGTTGCEFVQALNLKSGQVFSTIAFDESGNLLGFVIEESTGAPSLAKYEFDRENFKLAKEAAFIKSFDDSKLPYVDSVSFLFKKKFDNIKDYQERKRKRIEENNKQLG
What is the function of this protein?
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.  In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRO1_ARMOS
Sequence: MSQRIFLPDTLANWQWPRHLNPHYAEVKKASAAWAQSFRAFQTKAQEAFDRCDFNLLASFAYPLADEGDGCDLMNLFFVIDEYSDVSTEEEVRAQKDIVMDAIRNTEKPRPAGEWIGGEVARQFWDLAKKTASSQAQKRFIDTFDEYLESVVQQAADRNNSHIRGIESYLEVRRCTIGAKPSFALLEFDMQLPDEVINHPVIKELEKSCIDMLCLGNDVVSYNLEQARDDDGHNIVTIAMNELRTDVAGAMIWVDEYHKQLESRFMENFKKVPRWGGPIDLQVARYCDGLGNWVRANDQWSFESERYFGKKGPEIIQRRWITLMPKMVSEELGPQIVDGSHL
What is the function of this protein?
Delta(6)-protoilludene synthase, part of the gene cluster that mediates the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols (By similarity).  The first step in melleolides biosynthesis is performed by the delta(6)-protoilludene synthase PRO1 which catalyzes the cyclization of farnesyl diphosphate to protoilludene (By similarity).  The orsellinic acid synthase armB produces OA by condensing acetyl-CoA with 3 malonyl-CoA units in a three-round chain elongation reaction folowed by a C2-C7 ring closure (By similarity).  ArmB further catalyzes the trans-esterification of OA to the various sesquiterpene alcohols resulting from the hydroxylation of protoilludene (By similarity).  The melleolides cluster also includes 5 cytochrome P450 monooxygenases, 4 NAD(+)-dependent oxidoreductases, one flavin-dependent oxidoreductase, and one O-methyltransferase (By similarity).  The cytochrome P450 monooxygenases may be involved in protoilludene hydroxylation to elaborate melleolides with multiple alcohol groups, such as melleolide D, which carries alcohol functionalities at C-4, C-5, C-10, and C-13 (By similarity).  The role of the NAD(+)-dependent enzymes remains unknown (By similarity).  Numerous melleolides, including arnamial, show 5'-O-methylation of the aromatic moiety which may be catalyzed by the methyltransferase encoded in the cluster (By similarity).  The flavin-dependent oxidoreductase might represent the dehydrogenase yielding the aldehyde in position 1 of arnamial and other melleolides (By similarity).  Finally, several halogenases, localized outside of the cluster, are able to catalyze the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product (By similarity).
What are the official names of this protein?
Delta(6)-protoilludene synthase, Melleolides biosynthesis cluster protein PRO1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: OCTT_MYCHD
Sequence: MSGRRPTLLVFCDSLSYYGPRGGLPADDPRIWPNIVASQLDWDVELIGRVGWTSRDVWWAATQDPRAWAALPRAGAVIFATGGMDSLPSPLPTALRELIRYIRPPWLRRRVRDLYGWLQPRLSPVSRNALPPHLTAEYLEMTRGAIDFNRPGIPVVAALPSVHIADSYGRAHHGREATARAITEWARQHGVVLVDLKAAVADQVLNGRGNPDGIHWNFEAHQAVAELMLKALAEAGVPCR
What is the function of this protein?
Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP).  Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG).  Can also use hexanoyl-CoA as acyl donor in vitro.  DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can be used as substrate.  DGG and GG are the two earliest intermediates in MGLP biosynthesis.
What are the official names of this protein?
Diglucosylglycerate octanoyltransferase, DGG octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the OctT acyltransferase family.
Protein: PLIAA_PROFL
Sequence: HETDPDGQVMSSMIETLMFLQKEYANLRYAFMTVNNARSFGSGSERLYVSNKEIKTFEPLKEICEEAGGHIPSPQLENQNKAFASVLERHNKAAYLVVGDSANFTNWAAGQPNEADGTCVKADTHGSWHSASCDENLLVVCEFYFIL
What is the function of this protein?
PLI binds directly phospholipase A2 in the presence or absence of calcium.  Inhibitory activity of the PLI-A homotrimer is more specific than that of the PLI-B homotrimer.
What are the official names of this protein?
Phospholipase A2 inhibitor subunit A, alpha-PLI A.
What is the protein family that this protein belongs to?
Belongs to the alpha-type phospholipase A2 inhibitor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in plasma.
Protein: TRMFO_SYNE7
Sequence: MAAISQPVIVIGAGLAGTEAAWQIAEAGVPVILYEMRPQRQSPAHHSESFAELVCSNSFGAMASDRAAGLLHEELRRLGSLVFSKASEHQVPAGGALAVDRALFSEDLTRTVADHPLVEIRREELRSLPTEGIVVLCTGPLTSPDLAEDLQRFTGQDYCSFFDAASPIVTGESIDQAIAFRASRYDKGEAAYLNCPLNRDQYLAFREALVTAEQAELKDFEQESAKFFEGCLPIEELARRGEDTMRYGPLKPVGLFDARLGDWRDPENRSRRPYAIVQLRQEDRAGNLWNLVGFQTNLRWGEQKRIFQMIPGLSQAEFVRFGVMHRNTFVNAPQLLDASLQFRQRPTLLAAGQLIGTEGYSAAVAGGWLAGTNAARLALGRSPLVLPDTLVSGSLFRFISSAEPKYFQPMPPNFGILPNLEQPPRNKKDRYAAYRDRALQDLRDWQQTHAIGNLSPSTGLATTAIA
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T62_TERAN
Sequence: MATSGRLLCVCLVLGLVFGSLGYPVMEKKRAGKNFDLGTIANWAWQIGEKGGEIIDAIGTSNVPCGDGTCQFGCCEDDRCEDLGCDTFSSS
What are the official names of this protein?
Teretoxin Tan6.2.
What is the protein family that this protein belongs to?
Belongs to the teretoxin M (TM) superfamily.
What are the subcellular locations of this protein?
Secreted.