PharMolix/UniProtQA huggingface dataset:
Protein: PLCD3_MOUSE
Sequence: MLCGGWKRSRRSPEESRVSAQVAAPLAFPPSPASSDSSTKRPGLRALKKMGLTEDEDVQAMLRGSRLLKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAASKHIFFVQHIEAVREGHQSEGLRRFGGAFAPACCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLAKLRARLDAMSQRERLDHWIHSYLHRADSDQDSKMSFKEIKSLLRMVNVDMNDMYAYRLFKECDHSNNERLEGAEIEAFLRRLLKRPELEEIFRRYSGEDRVLSASELLEFLEDQGEDGATLACAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVRDHAFTSSPYPVILSLENHCGLEQQAVMARHLRSILGDMLVTQALDSQNPEELPSPEQLKGRILVKGKKLPAARSEDGRILSDREEEEEEEEEAEEALEAAEQRSRAKQISPELSALAVYCCATRLRTLDPSPGPPQSCTVGSLSERKARKFTREAGTSFVRHNTQQLTRVYPLGLRMNSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGRFLINGQCGYVLKPAYLRQLNTTFDPECPGPPRTTLAIQVLTAQQLPKLNAEKPSSIVDPLVRVEIHGVPEDCAQKETDYVLNNGFNPCWEQTLQFRLRAPELVLVRFVVEDYDTTSPNDFVGQSTLPLSSLKQGYRHIHLLSKDGASLAPATLFVHIRIQNS
What is the function of this protein?
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).  DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores.  Essential for trophoblast and placental development.  May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.  Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (PubMed:21187285).
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, Phosphoinositide phospholipase C-delta-3, Phospholipase C-delta-3, PLC-delta-3.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.
Protein: ATPD_TRIL1
Sequence: MINNAIARRYAKALVQLGSEKDLIDRFSQELKVVSGVFAGNAELRAAFGNPAFTADQKKQIMRDLIARMQCSELVANFLLLLVDKNRVVCLPEIVETYEKLADEQSGVIRPMITTAFALDDSQVNAIKGALEQKTGKKVVPQVKVDQSLIGGVVTQIGDIAYDSSVKTQLARIHDILQKG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NDHJ_OENEH
Sequence: MQGRLSAWLVKHGLVHRSLGFDYQGIETLQIKPEEWHSIAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGVDQAEEVCIKVFAPRNNPRIPSVFWVWKSADFQERESYDMLGIRYDNHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: PROA_TREPS
Sequence: MVEVYARLRAAVARLAVCSAAEKDGALRAVRDALHAQREDILRANAQDLARAREAGLAAPLVARLALSEHLLEDMLRSLTVLSLQRDPIGEIIEGYTLANGLEIRKVRVPLGVVAVIYESRPNVTVDAFALAYKSGNAVLLRAGSAASYSNAPLLRAIHVGLKKAHGVVDAVAVPPVLEEKYGDVDHILRARGFIDAVFPRGGAALIRRVVEGAHVPVIETGCGVCHLYVDESANIDVALQIAENAKLQKPAACNSVETLLVHRAVARPFLHRVQEIFATCEETTRKPGGVDFFCDAESFSLLTERGARKNVFHAQAETWDREYLDYQVSVRVVPNLEEALRHIARHSTKHSEVIVTRDRARARRFHQEVDAACVYVNASSRFTDGGQFGMGAEIGVSTQKLHARGPMGLCALTTSKYLIDGEGQVRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_RAT
Sequence: MTEWETATPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAANGFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINARKGSSNSYAIKKKDELERVAKSNR
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: CKB22_ARATH
Sequence: MDNNGVKPAVSAMEAFEKLEKVGEGTYGKVYRAREKATGMIVALKKTRLHEDEEGVPPTTLREISILRMLARDPHIVRLMDVKQGINKEGKTVLYLVFEYVDTDLKKFIRSFRQAGQNIPQNTVKCLMYQLCKGMAFCHGHGVLHRDLKPHNLLMDRKTMTLKIADLGLARAFTLPMKKYTHEILTLWYRAPEVLLGATHYSTGVDMWSVGCIFAELVTKQAIFAGDSELQQLLRIFRLLGTPNEEVWPGVSKLKDWHEYPQWKPLSLSTAVPNLDEAGLDLLSKMLEYEPAKRISAKKAMEHPYFDDLPDKSSL
What are the official names of this protein?
Cyclin-dependent kinase B2-2, CDKB2;2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: MSCL_BRUME
Sequence: MLKEFQEFALKGNMVDLAIGVIIGGAFGGLVNSIVNDIIMPIIGLITGGIDFSNMFIQLAGDPKTTLAAAREAGATIAYGNFITLLINFLIIAWVLFLVVKLMNRLKKREEAKPAPAAPSEEVLLTEIRDILAKQQKA
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NSA2_DEBHA
Sequence: MPQNEYIEQHIKQHGRRLDYEERKRKKAAREGHRIAKDAQELKGWRGKQFAKKRYSEKVAMKKKIKTHQESKVKGPATPKEDDGEALPTYLLDRQTNNSAKAISSSIKQKRLEKADKFAVPLPRVKGISEEEMFKVIKTGKQKSKAWKRMITKHTFVGEGFTRRPVKMERIIRPSALRQKKANVTHPELAVTVFLPILGVKKNPQSPMYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWGKYAQITNEPDRDGCVNAVLLV
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  May play a part in the quality control of pre-60S particles (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein NSA2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CECP2_ASCSU
Sequence: MIFIYLLVQTAESSWLSKTYKKLENSAKKRISEGIAIAIQGGPRRRRFVVQQDTISPRLEVDERFLPNSVQEQI
What is the function of this protein?
Has antibacterial activity against several Gram-positive and Gram-negative bacteria.  Is weakly active against yeasts.  Acts by a nonpore mechanism.
What are the official names of this protein?
Cecropin-P2.
What is the protein family that this protein belongs to?
Belongs to the cecropin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRUA_PARDP
Sequence: MPRFALLIEYDGSPFAGWQAQAERPSVQSTIEAALGRLDPGFAAGARIAAAGRTDAGVHATGQVAHADLARDWDPFRLSEALNWHLKPAPVAILAAARVADDFHARFSAHERRYLFRLVARRAPLTHDRGRAWQVPHRLDLAAMRAGAAHLLGRHDFTTFRSTMCQANSPVKTLDELTIDEAEIPQGREYRFFLRARSFLHNQVRSIVGTLERVGAGAWPPGRVAEALAACDRAACGPVCPPQGLYLTGVGYETPPFSDSR
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: TUS1_YEAST
Sequence: MYRYNRSSPFERTPEKRVSRQESQRKSIELPKLPPLNTRNSFLDDSDNGTDNISIGWTPISDTQQFQSPVPQAFTFTSKHSARGNGTSSSESTPKSTKYVKERRPPPPPPLLYSTESIRIDSPMVSPSSQSRERSPNKLSFIGNSEERHHMEYISNHSRILKSPFANGFSPNSPKSPRDSSKQQAHFSDESDLRCHEREKALPPIPFTTTLLLSPFDDEDSEFFTKPPPPLSTSRNVSGNSRVSEALESVYSDSDYTFNNSNARQSSFNSLLGAKPLELAPSITAPTQPFSIQSIDEHKLYQCDNVYKLSAIYEWILKVYFEWFNECVFTKIDLFQIVQLLLEFQMPTNFDQDTIDSNVDNIMASFISQKAVRFDIINDEEVAVVVGGLDITGVFTELLPCYSFIDNTYGSTNSLICYSNVCTHGQSSGFRKEIKLSEIINKSVGLWTEYWHLTPDDLAEINPREVQRQSFIFDLIILEERSLNMATAAVEIYGKRFDKSLLPDEPEFKALAFDIFEPLIQLHTEFLLTPIFWKLKTRGKFIDGVGKIYSKWCGEAKNIYLNYAKAMATVHEIIMWEKKNKTKFVTWLKEIDNSVEITRSKMYHDVIFFGGFFKSLQNMPVTLRSILKNTDPSMEDYEYLKIVIKEVEKLNFEVNQVHGLAIDHRKLVRFSKQLVLSTNSSNATSYVNVGGSTNANDDDAIQDKLALGLTYPERKLVLSGTVYKKRDLWLDPTPVYIALLDNCLLITEEISKGETQKYKLIERPIPIDYLSLEKRKIPGTSKQPLRNYSQKEHKSPMHNFSTPINSMRPLLKSSGNHMSTAYGDRKTSNTEISNANPNTDEFSFKIRNTATGESFKFFTESAEVLNQWIDAIMESFKRNAENHDLNAFEFTVLSSEFAYFDKDAPVNLPVAPEGSEIDVALKAYAQKANKDSCSWSKTTRILCCEDVKFEGRIYLFVATTDGIYVKYRDDYGSGFVKILELNDVKRMEANVKLGLLFVLDNRKLCYFNISTVVSRYLAQGNTLDENCIVGTVIRDKVRFFKIADDFGNSKHLFFERKGKIVILTPEFDQLTNQVKYFKFYKEYKLPSSSNNILNNEIEDIAIFRKSFAVCTKKTVILYQDSFEDNGIVLPSFLNDKDMMAHLRHPHLNSLPFKSATDSKKRPSIESLTEEAKKDIATCKAIPVNFFQISQSSFFALVYDEAVVKINCYGEMSDWRKDILLLDFCCTGASFHGNHLILVGDNLIQIYDLKNVEQNLGELVPVQIIKGKKIKLASSERREKTILVLSHPNILNRQLLVACNPVAMADHQ
What is the function of this protein?
Guanine nucleotide-exchange factor (GEF) for RHO1 that stimulates the exchange of RHO1 GDP-bound form into GTP-bound form.  Required for signaling of cell wall defects to RHO1.
What are the official names of this protein?
Rho1 guanine nucleotide exchange factor TUS1, TOR unique function suppressor protein 1.
Protein: DLTC_STRR6
Sequence: MDIKSEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVEIENRFDIRVPVTEFGRDDWNTANKIIAGIVELQNA
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_COXBN
Sequence: MSGGVKLIAGLGNPGDQYARTRHNVGAWFLETLAQQRNQSLAKENKFHGFVAKCNDYWLLKPTTFMNESGQAVAALARFYKIKPSEILIAHDELDFPAGDIRLKEGGGHGGHNGLRNIIQHLGSSDFYRLRIGINHPGHKDRVTPYVLSPPSENDRIAILAAIEKGLRLIPELVQGDFQKVMRELHS
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC_DANRE
Sequence: MGDVEKGKKVFVQKCAQCHTVENGGKHKVGPNLWGLFGRKTGQAEGFSYTDANKSKGIVWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKSATS
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: MYG_HALDV
Sequence: MADIQLSKYHVSKDIGFLLEPLQDVLPDYFAPWNRLAKSLPDLVASHKFRDAVKEMPLLDSSKLAGYRQKRLAHLQLVLITSGYLWQEGEGGAVQRLPECVAKPLWNVSNDLGLKPVLTYGDVCLTNCRVKGGDIEVMYNLPGGAGTEWFLKVCGLVELTLGKGAQSVQNVLDGAKANDKAKMTSGLTELTTTIGNMQAALAKMNDNLTPDHFYNVLRPFLGGFGGPASPISGGLIYEGVSDAPVTMIGGSAAQSSAMQLLDNLLGVTHSPDKQAFLDEISNYMIPAHKQLLADLTKMPRKVPQIVAEAKDANLSKAYSGCVAALTQYRTYHIQVVTKYIVTASKSDSPKSLAYKDTGKSDLIPFLKEVRDDTEKMQK
What is the function of this protein?
Serves a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the indoleamine 2,3-dioxygenase family.
Protein: RLMH_POLNA
Sequence: MRLTIVAVGQKVPDWAQTAYDDYAKRFPPELKVELKAVKTEPRGSKTLENLLAAERTRIEGAIARGCRIVALDERGTAVTTMALAEHLKNWQLSGDDVAIVIGGPDGLDAGFKQSAHQRIRLSDLTLPHAMVRVLLIEQLYRAWSITINHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT52_CONMI
Sequence: MRCVPVFIILLLLIPSASSVDVQPLTRDDVPLASFLDDARRTLRSPWMTRRCCPGNFACCGK
What are the official names of this protein?
Conotoxin Mi5.2, Conotoxin Mi T-1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YBGC_HAEIN
Sequence: MLDNGFSFPVRVYYEDTDAGGVVYHARYLHFFERARTEYLRTLNFTQQTLLEEQQLAFVVKTLAIDYCVAAKLDDLLMVETEVSEVKGATILFEQRLMRNTLMLSKATVKVACVDLGKMKPVAFPKEVKAAFHHLK
What is the function of this protein?
Displays acyl-CoA thioesterase activity with short chain aliphatic acyl-CoA thioesters, such as propionyl-CoA and butyryl-CoA.  Enzyme activity is relatively low, suggesting that the acyl-CoA thioesters used in the assays are not the physiological substrates.  Has no detectable activity with 4-hydroxybenzoyl-CoA, lauroyl-CoA (C12:0), arachidoyl-CoA (C20:0) and arachidonoyl-CoA (C20:4).
What are the official names of this protein?
Acyl-CoA thioesterase YbgC.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
Protein: ADEL_APLDA
Sequence: DPDKCKTIRVESWSYKYAEKVVEDASYVLNMTVVDRQSAAACTLGESFGYQKATLWVDHGCRADFKVCYLPVMPTECQTLRVESWNYKYAEKVVEGAALFINMTVEDRQSEASCDLDKSFGFYNQNSTVWVNHGCRADFNICYLKGAVTTSTINVSSWNYQYATKVLPAASCIYSMRVVNQQSAAPCTLGTTYGFVANTMWVDDGCRADFKPSYYSP
What is the function of this protein?
Binds in decreasing order of affinity: galacturonic acid, D-galactosamine, methyl-alpha-D-galactopyranoside and further galactose-containing carbohydrates.  Has hemagglutinating activity against human and rabbit erythrocytes.
What are the official names of this protein?
Lectin ADEL.
Protein: CLPX_RHOOB
Sequence: MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAESSEVKLDELPKPAEIRDFLENYVIGQDAAKRTLAVAVYNHYKRIQAGDKGRDARGETVELAKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQIDTTNVLFIVAGAFAGLERIVSDRVGKRGIGFGAEVRSKAEIDTQDHFAEVMPEDLIKFGLIPEFIGRLPVVASVTNLDKESLVQILSEPKNALVKQYNRLFDMDGVELEFTTDALEAIADQAILRGTGARGLRAIMEEVLLPVMYDIPSRDDVEKVVVSAETVNDNVLPTIVPRKPERGERRDKSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: NTPP_COREF
Sequence: MQIVLASQSPSRLMILRQAGVEPVIHPAHVDEDAIIAQLAGAEPDEIVTRLALAKAQAIAPEHPGDVVIGGDSMLLLDGQLQGKPHTPEATIERWRQQRGRTAHLITGHAICLGERRVVEASRTTIHFADASDTDIEAYARSGEPLQCAGAFTLEALGGWFIDAIEGDPSSVIGLSLPVVRRALYSFGLNASDFWTK
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN183_BOVIN
Sequence: MAEQQGREPECPVCWNPFNNTFHTPKVLDCCHSFCVECLAHISLVTPTRRRLLCPLCRHPTVLASGQPVTDLPTDTAVLTLLRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTLDLGPEPASQAGQPQDVGPSTRPVPIRSRYSLRECFRNPHFRIFAYMMAVILCGTVLFIFSIFCTRRFFWGVG
What is the function of this protein?
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.  Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1.  May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF183.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum. Golgi apparatus, cis-Golgi network membrane. Lysosome.
Protein: RRP8_CAEEL
Sequence: MGKKRKITDEKDAQHVPAEKREKVENWLKKSTEKPTSSQSDAEKKKKRPWRNKVRKLAAKKAAADKKSENPEEPPLILEPKSSSDENTKKKRKRGPKKKKFKPEVAGKAAETENDDVAAAPEEADPIAEAKKRLDAGRFRFLNEKLYTCTGSEAFDFFKEDPTAFDLYHKGFADQVKKWPNHPLREIIRWLQSKPDQQSVFDLGCGEAKIAEAVGEKHKIRSFDLVAVNDRVESCDMSKLPAEDSSADIVIYCLSLMGTNLYDFIREARRVLKIGGILKIAEVTSRFVSIKQFCEAITKMGFEQSHRRELTDYFMMMEFKKVEKVEQKRPYGLKLKPCLYKKR
What is the function of this protein?
Probable methyltransferase required to silence rDNA.
What are the official names of this protein?
Ribosomal RNA-processing protein 8.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RRP8 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: S35A2_MOUSE
Sequence: MAAVGVGGSTAAAGAGAVSSGALEPGSTTAAHRRLKYISLAVLVVQNASLILSIRYARTLPGDRFFATTAVVMAEVLKGLTCLLLLFAQKRGNVKHLVLFLHEAVLVQYVDTLKLAVPSLIYTLQNNLQYVAISNLPAATFQVTYQLKILTTALFSVLMLNRSLSRLQWASLLLLFTGVAIVQAQQAGGSGPRPLDQNPGAGLAAVVASCLSSGFAGVYFEKILKGSSGSVWLRNLQLGLFGTALGLVGLWWAEGTAVASQGFFFGYTPAVWGVVLNQAFGGLLVAVVVKYADNILKGFATSLSIVLSTVASIRLFGFHLDPLFALGAGLVIGAVYLYSLPRGAVKAIASASASGPCIHQQPPGQPPPPQLSSRGDLTTEPFLPKSVLVK
What is the function of this protein?
Transports uridine diphosphate galactose (UDP-galactose) from the cytosol into the Golgi apparatus (PubMed:10578063).  It functions as an antiporter that exchanges UDP-galactose for UMP (By similarity).  It is also able to exchange UDP-galactose for AMP and CMP, and to transport UDP-N-acetylgalactosamine (UDP-GalNAc) and other nucleotide sugars (By similarity).  As a provider of UDP-galactose to galactosyltransferases present in the Golgi apparatus, it is necessary for globotriaosylceramide/globoside (Gb3Cer) synthesis from lactosylceramide (By similarity).
What are the official names of this protein?
UDP-galactose translocator, Solute carrier family 35 member A2, UDP-galactose transporter, UDP-Gal-Tr, UGT, mUGT1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: U375E_CAEEL
Sequence: MNSFVSTVLLLSVTIALVSGYPSQLQTTCVTKAKSCTMFFLNGVYCTECTYSGTLELKIGSTCTFSIYEKKVASQPNENSQNEVAQCKQSSCYSNQYVPVDCAAAFGNEYITYIENQ
What is the function of this protein?
Negatively regulates the egg-laying rate by promoting retention of fertilized eggs.
What are the official names of this protein?
UPF0375 protein Y45F10C.2.
What is the protein family that this protein belongs to?
Belongs to the UPF0375 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KCY_PRUAR
Sequence: MWRRVTSVSHLFSHSKSTKFNQGASTFKIWETFTSESEIPTPSKGSPFVTFVLGGPGSGKGTQCAKIVEAFGFTHVSAGDLLRREIASGSAYGSVILSTIREGKIVPSQVTVELIQKEMESSDNYKFLIDGFPRSEENRKAFEQTIGAEPDVVLFFDCPEQEMVKRVLNRNQGRVDDNIDTIKKRLEIFDELNWPVINYYSQRGKLHKINAVGTVDEIFEKVRPIFAPLSK
What is the function of this protein?
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP.  Plays an important role in de novo pyrimidine nucleotide biosynthesis.  Has preference for UMP and CMP as phosphate acceptors.
What are the official names of this protein?
UMP-CMP kinase, Deoxycytidylate kinase, CK, dCMP kinase, Uridine monophosphate/cytidine monophosphate kinase, UMP/CMP kinase, UMP/CMPK.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RAB6C_HUMAN
Sequence: MSAGGDFGNPLRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLWDTAGQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIITLVGNRTDLADKRQVSVEEGERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSREDMSDIKLEKPQEQTVSEGGCSCYSPMSSSTLPQKPPYSFIDCSVNIGLNLFPSLITFCNSSLLPVSWR
What is the function of this protein?
May be involved in the regulation of centrosome duplication and cell cycle progression.
What are the official names of this protein?
Ras-related protein Rab-6C, Rab6-like protein WTH3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.