PharMolix/UniProtQA huggingface dataset:
Protein: CD4_RAT
Sequence: MCRGFSFRHLLPLLLLQLSKLLVVTQGKTVVLGKEGGSAELPCESTSRRSASFAWKSSDQKTILGYKNKLLIKGSLELYSRFDSRKNAWERGSFPLIINKLRMEDSQTYVCELENKKEEVELWVFRVTFNPGTRLLQGQSLTLILDSNPKVSDPPIECKHKSSNIVKDSKAFSTHSLRIQDSGIWNCTVTLNQKKHSFDMKLSVLGFASTSITAYKSEGESAEFSFPLNLGEESLQGELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQLSETLPLTLQIPQVSLQFAGSGNLTLTLDRGILYQEVNLVVMKVTQPDSNTLTCEVMGPTSPKMRLILKQENQEARVSRQEKVIQVQAPEAGVWQCLLSEGEEVKMDSKIQVLSKGLNQTMFLAVVLGSAFSFLVFTGLCILFCVRCRHQQRQAARMSQIKRLLSEKKTCQCSHRMQKSHNLI
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex.  The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells.  In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway.  Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
What are the official names of this protein?
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, W3/25 antigen.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts.
Protein: UVRC_TRIV2
Sequence: MRTSAQILPLVKDPERLEARLSEIPPEPGVYFMRDGSDRIIYIGKSRKLRSRVRSYFREGYNKTERIATMAKLVTEIEFIVTDTEAEALALEANLIKQHQPYFNVLLKDDKKYPYVCITWSEDYPRIFITRKRQLGKEKDKYYGPYTDSGLLREILRISKRIFALRQRPQPLFKDRPCLNYDLGRCPGVCQQLISPEEYRKTVQKVAMVFQGRTQELIDILSEQMEKAAEALNFEVAARIRDQIAGLKSLTAEQKVSLPDDTVSRDAIALAADAQHACIQLFQIRAGQLVGRLAFVAESHAEPGAILQRVLEEHYQTAESVEIPAEILVQHELPDAEILADVLTQRKGRKVTIFTPQRQVKAELIEMVERNAQYELQRMQKLGDRNHQATQDLAAILDLPDLPHRIEGYDISHIQGSNAVASQVVFIDGLPAKQNYRHYKIKNPTVTIGHSDDFASLAEVIQRRFRKYAEDPQLSRVGNPDWPDLIMIDGGKGQLSSVVAVLQEMNLLEDLRVISLAKRREEIFLPGESQPLKTDAEQPGVQLLRRLRDEAHRFAVSFHRQQRSDKLKRSRLDEIPGLGHHRQKQLLAHFRSVDYIRQATPAQIAEVPGIGPHLAQAIYDYFHPSHV
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LNP_TAICA
Sequence: MRSSTHIFVSFVVYCGVFVTSAIALSNHTNAYQCDRWSNVLNELQANLFHEGQCRSAALRASGTFGGGGADGSIIQFAHTELAYPANEGLEEMVYTLKHFADGHEVSYGDMIQFAGAVALSNCPGSPRLRFYAGRPEAIAPSPPNLLPLPTDPVEKILSRMADAGFNAGDTVALLAAHSIAVQNTIDPSIPDSPLDSTPRIFDTQFYLETLLRGTRYPGKGRGPAQSKSPIEHEFRLASDAAIARHTSTACEWQSFIDNQEGLRSAFRNAMVKLANQGHDNLVDCSFVIPVPPPWNLPVEYPSGKSRSDVEQSCSDVPFPTISLNSDVHD
What is the function of this protein?
Can oxidize the lignin redox mediator veratryl alcohol to veratryl aldehyde.  May be involved in oxidation of lignocellulose substrates.
What are the official names of this protein?
Low-redox potential peroxidase, Putative ligninolytic peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ligninase subfamily.
Protein: CAP9_ADECR
Sequence: MDPQQKGIVNTCFLTTRIPSWAGARQNVTGSDLGGKPVPSDVLESGRPLAAPRVRTLYEEQQLNMLTVNVILDDLKTQVAAMQNSVTAIQEELKDLKQRVAAR
What is the function of this protein?
Structural component of the virion that acts as a cement protein on the capsid exterior and forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons.  Dispensable for assembly.  During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force.  The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus.
What are the official names of this protein?
Hexon-interlacing protein, Protein IX.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae hexon-interlacing protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Located in the canyons between the hexons on the outer surface of the capsid. Forms a sort of hairnet on the outer side of the virion. Present in 240 copies per virion.
Protein: DDHD2_MOUSE
Sequence: MSSGESHQEQLSQSDPSPSPNSCSSFELIDMDASSSYEPVSPHWFYCKVLDSKELWIPFNSEDSQQLEDAYGSGKDCNERIVPTDGGRYDVHLGERMRYAVYWDELPSEVRRCTWFYKGDKDNKYVPYSESFSQVLEDTYMLAVTLDEWKKKIESPNREIIVLHNPKLMVHYQPIAGSDEWGSTSTEQGRPRSVKRGVENIPVDIHCGEPLQIDHLVFVVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENEQIGRVEFLPVNWHSPLHSTGVDIDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIVDTVASEMNRIYTLFLQRNPDFKGGVSIAGHSLGSLILFDILTNQKNSIGDIDSEKGSLSSAEDRGDASTLEEDLKKLQLSEFVTVFEKEKVDREALALCTDRDLQEMGIPLGPRKKILNHFSARKNSVSINRPAMSASEVNISKENGDYLDVGIGQVSVKYPRLNYKPEIFFAFGSPIGMFLTVRGLRRIDPNYKFPTCKGFFNIYHPFDPVAYRIEPMVAPGIEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRGPYPALQASETAEETEAEPESSSEKSNEANTEEPPVEVKEEAPISVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGVFLDQPLQ
What is the function of this protein?
Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine.  Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).  May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures.  May regulate the transport between Golgi apparatus and plasma membrane (By similarity).
What are the official names of this protein?
Phospholipase DDHD2, DDHD domain-containing protein 2, SAM, WWE and DDHD domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PA-PLA1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P (By similarity).
Protein: Y313_STRU0
Sequence: MKNTSIKTVVAIGIGAALFVIIGLFVPITIFTNTTISLQYAVQALFSVLFGPVAGFFIGFIGHMLKDMFAGYGVWWSWVLPSGLVGLGIGSLKNRLKVDKGIFSKKDILSFNLVQALVNLISWAIVAPLGDILIYQEPANKVFTQGLFAAFANTFTIGIGGTLLLIAYANSRPKAGSLRKD
What are the official names of this protein?
UPF0397 protein SUB0313.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBIC_ECO57
Sequence: MSHPALTQLRALRYCKEIPALEPQLLDWLLLEDSMTKRFEQQGKTVSVTMIREGFVEQNEIPEELPLLPKESRYWLREILLCADGEPWLAGRTVVPVSTLSGPELALQKLGKTPLGRYLFTSSTLTRDFIEIGRDAGLWGRRSRLRLSGKPLLLTELFLPASPLY
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYETA_XENLA
Sequence: MMNFRQRMGWIGVSLYLFVSAAAFYYVFEINDTYNKLALEHVQLKPQEPHRGTTWTHSLKARLLSLPFWLWATLFLIPYFQVFLFLYSCTRADPKTVGYCIIPICLAIICNRHQSFVRASNQISRLQLIDT
What is the function of this protein?
Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes.  LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB.  GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes.  LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases.
What are the official names of this protein?
Lysosomal enzyme trafficking factor, Transmembrane protein 251, Transmembrane protein 251-A.
What is the protein family that this protein belongs to?
Belongs to the LYSET family.
Protein: INGR2_HUMAN
Sequence: MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
What is the function of this protein?
Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114, PubMed:7615558).  Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148).  Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114).
What are the official names of this protein?
Interferon gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, Interferon gamma receptor accessory factor 1, AF-1, Interferon gamma receptor beta-chain, IFN-gamma-R-beta, Interferon gamma transducer 1.
What is the protein family that this protein belongs to?
Belongs to the type II cytokine receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm. Note=Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling.
Protein: SPIK2_ADE41
Sequence: MKRTRIEDDFNPVYPYDTFSTPSIPYVAPPFVSSDGLQEKPPGVLALKYTDPITTNAKHELTLKLGSNITLENGLLSATVPTVSPPLTNSNNSLGLATSAPIAVSANSLTLATAAPLTVSNNQLSINAGRGLVITNNALTVNPTGALGFNNTGALQLNAAGGMRVDGANLILHVAYPFEAINQLTLRLENGLEVTSGGKLNVKLGSGLQFDSNGRIAISNSNRTRSVPSLTTIWSISPTPNCSIYETQDANLFLCLTKNGAHVLGTITIKGLKGALREMHDNALSLKLPFDNQGNLLNCALESSTWRYQETNAVASNALTFMPNSTVYPRNKTAHPGNMLIQISPNITFSVVYNEINSGYAFTFKWSAEPGKPFHPPTAVFCYITEQ
What is the function of this protein?
Forms spikes that protrude from each vertex of the icosahedral capsid.  Interacts with host receptor CXCAR to provide virion initial attachment to target cell.  Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
What are the official names of this protein?
Fiber protein 2.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae fiber family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Anchored to the pentons, protrudes from the virion surface.
Protein: RS8E_NANEQ
Sequence: MAYPYQGRDNRLITGRIHPRARKKRKYELGREPTFTRVGERKIKKIRVRGGNIKIRLKRDMYVNVYDPTQGKTVKAKIVRFLDNPSNRNFARMGILTKGAIVETELGKVKITSRPGQDGVLNGVLIQ
What are the official names of this protein?
30S ribosomal protein S8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: PSTS_STAAR
Sequence: MKKWQFVGTTALGATLLLGACGGGNGGSGNSDLKGEAKGDGSSTVAPIVEKLNEKWAQDHSDAKISAGQAGTGAGFQKFIAGDIDFADASRPIKDEEKQKLQDKNIKYKEFKIAQDGVTVAVNKENDFVDELDKQQLKAIYSGKAKTWKDVNSKWPDKKINAVSPNSSHGTYDFFENEVMNKEDIKAEKNADTNAIVSSVTKNKEGIGYFGYNFYVQNKDKLKEVKIKDENGKATEPTKKTIQDNSYALSRPLFIYVNEKALKDNKVMSEFIKFVLEDKGKAAEEGGYVAAPEKTYKSQLDDLKAFIDKNQKSDDKKSDDKKSEDKK
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.
What are the official names of this protein?
Phosphate-binding protein PstS, PBP.
What is the protein family that this protein belongs to?
Belongs to the PstS family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: HYPA_DESHY
Sequence: MHEMSLMGGVFEAIEATLAHHHVKKVLLVKLKIGQLTNAEPDALQMAFAAFAQGTVCEGAELQIEMLPVKGRCRSCSEEFMVPGLIFACPVCQHLGIDITQGEELLLESLEVEE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: GLPB_PHOPR
Sequence: MKFDSLIIGGGVAGLSCAIRCAEAGMKTAVIAAGQSALHFSSGSIDFLSRLPNGQPVYHPMAAFNELQQQSPEHPYCKLGKRKVQEALDWYQEMIKARGIYLSSQEDEANHLRLTPMGTFRSTWLSQQTVHQFPLTNTAGELNHIALVTVDGFRDFQPKLAADNLSKLAQFKDVKITTAAVELPDFEEMQRNPCEFRSIDISRVLRDERKLHAFAKSMIQAVGKADLVVLPAVFGNGDGAATIKLLEGLTGFTICELPTMPPSLLGIRLEEAMKSHFKMLGGIILVGDEVQRGDIEDGELKRIFTRNHRDMPLIADNYLIATGSFFSRGMAAQRLSIDEPIFNLDTVAIPDRDQWYQPEFFASKAHPFLKMGVICNDQLQASANNQTIDNLFCAGALLAHYDPVFEGCGSGVAISTGFHVAEQMISKHTARQNQNNKERTIA
What is the function of this protein?
Conversion of glycerol 3-phosphate to dihydroxyacetone.  Uses fumarate or nitrate as electron acceptor.
What are the official names of this protein?
Anaerobic glycerol-3-phosphate dehydrogenase subunit B, Anaerobic G-3-P dehydrogenase subunit B, Anaerobic G3Pdhase B.
What is the protein family that this protein belongs to?
Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
Protein: COQ4_AJEDR
Sequence: MTPAVTQTILTVRIARPHGYGYVLLSRGFSALNRPPPNYPGHIPLTTIERGALAVGSAIGSLLNPRRGDLIAALGEATATPYFIYRLRDAMLSDPTGRRILRDRPRISSKTLSIEYLRSLPPNTVGRTYVGWLDREGVGPDTRAPVQYIDDEECAYVMQRYRECHDFYHAITGLPVVVEGEVALKTFEFANTLLPMTGLSMFAVMRLKPAERERFWKLHLPWAIRSGLASKEVINVYWEEQLERDANELREELGIEKPADLREIRKMMRRQKAAEEAAKAKDGQ
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: TPL_ARATH
Sequence: MSSLSRELVFLILQFLDEEKFKETVHKLEQESGFFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDKHDRPKAVDILVKDLKVFSTFNEELFKEITQLLTLENFRENEQLSKYGDTKSARAIMLVELKKLIEANPLFRDKLQFPTLRNSRLRTLINQSLNWQHQLCKNPRPNPDIKTLFVDHSCGPPNGARAPSPVNNPLLGGIPKAGGFPPLGAHGPFQPTASPVPTPLAGWMSSPSSVPHPAVSAGAIALGGPSIPAALKHPRTPPTNASLDYPSADSEHVSKRTRPMGISDEVNLGVNMLPMSFSGQAHGHSPAFKAPDDLPKTVARTLSQGSSPMSMDFHPIKQTLLLVGTNVGDIGLWEVGSRERLVQKTFKVWDLSKCSMPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRQHLEIDAHVGGVNDISFSTPNKQLCVITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVCPHYKENIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFSCGTSKDGESFIVEWNESEGAVKRTYQGFHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQLLTAIDGDGGLQASPRIRFNKEGSLLAVSGNENVIKIMANSDGLRLLHTFENISSESSKPAINSIAAAAAAAATSAGHADRSANVVSIQGMNGDSRNMVDVKPVITEESNDKSKIWKLTEVSEPSQCRSLRLPENLRVAKISRLIFTNSGNAILALASNAIHLLWKWQRNERNATGKATASLPPQQWQPASGILMTNDVAETNPEEAVPCFALSKNDSYVMSASGGKISLFNMMTFKTMATFMPPPPAATFLAFHPQDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRSKVLPLPQGRPNSAPSDTRVQFHQDQAHFLVVHETQLAIYETTKLECMKQWAVRESLAPITHATFSCDSQLVYASFMDATVCVFSSANLRLRCRVNPSAYLPASLSNSNVHPLVIAAHPQEPNMFAVGLSDGGVHIFEPLESEGKWGVAPPAENGSASGAPTAPSVGASASDQPQR
What is the function of this protein?
Transcriptional corepressor.  May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis.  Regulates the expression of PLT1 and PLT2.  Negative regulator of jasmonate responses.  Negative regulator of auxin responses.  Negative regulator of multiple floral organ identity genes (PubMed:23034631).  Required for ovule development (PubMed:25378179).
What are the official names of this protein?
Protein TOPLESS, WUS-interacting protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOLD_BUCBP
Sequence: MLKKVLNGTRIAKKLEFKILKQVNYKLSLGQRPPGLAVILIGSNSASTIYVKKKRFMCEQVGFISKFWKFSKNIQESKILNLIYKLNYDTTIDGILVQLPIPPNINNQKLFSSIIPTKDVDGFHPYNIGSLCQKSPYLRPCTPFGIITMLKHYKIKIRGLHAVVIGASNIVGRPMSMELLLAGCTTTITHRFTKNLKHYVKQADLIVIAIGHAHFLKGTWIKKGAIVIDVGINRLKNGEIVGDVDFKTAYKKSSYITPVPGGVGPMTVITLLNNTLKAYEQISKDCK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SELD_CAMJR
Sequence: MQYKNQNLTHFVKAAGUAAKLSPGGLKTILNFMQKTPALLSDIGNNEDASVYQISRDLALVQTLDFITPIVDSAYHFGAIAAANALSDVFAMGAEVINALNIVGFDTCNHDVNILKELLEGANDKVQECNALVVGGHTIESTELFFGLSVTGKVHPSKFIANNTSKIGDCIILTKPLGTGILSTALKAQMLNQKHLDIMLKNMMELNYKASQIALKFHPSAMSDVTGFGLLGHLKEMLNKNISFEIFQNEILFLEGAKEYFNMGLIPAGAYKNLEFIKELIPDLNEEKLLLCDPQTSGGLLISISEKESLECLKKLEDENIQAKIIAKVVNKQENDIIIS
What is the function of this protein?
Synthesizes selenophosphate from selenide and ATP.
What are the official names of this protein?
Selenide, water dikinase, Selenium donor protein, Selenophosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Protein: PICK1_PONAB
Sequence: MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPARDTRGAAGPLDKGGSWCDS
What is the function of this protein?
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence.  Involved in the clustering of various receptors, possibly by acting at the receptor internalization level.  Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors.  May be regulated upon PRKCA activation.  May regulate ASIC1/ASIC3 channel.  Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis.  Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD).  Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function (By similarity).
What are the official names of this protein?
PRKCA-binding protein, Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Postsynaptic density. Synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Also membrane-associated, present at excitatory synapses.
Protein: MIAA_DESPS
Sequence: MEKIKQPVLVLVGPTAIGKTALSLQLARQFSCEVVSMDSMQVYRHMDIGTAKISKEEQGEVPHHLLDIVEPDEHYDASMYCRDALRTITEIHARGHIPLVTGGTGLYLQSLTKGFFEGPPSDSAVRERLQEELDNLGPEEMHARLEQLDPLSAQRLHPNDSYRVMRALEIFAITGKPWSQLLSQHKPENQFANMLQIGLTCDRPLLYDRINMRTQIMLDAGLEEEVRGLLDMGYSRELRSMGSIGYKHMANFIFGDWEFEEMKTLLARDTRRYAKRQYTWFNKDEDLHWYQKESKAEIVDRVGQWLEDQLSKNL
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GLMU_PSEAB
Sequence: MSLEIVILAAGQGTRMRSALPKVLHPIAGKPMLGHVIDCARQLQPERIHVVIGHGADLVRERMAADDLNFVLQAEQLGTGHAVAQALPFLSADQVLILYGDVPLIQLDTLQRLLAQVTPDQLSLLTVDMLDPTGYGRIVRDDQGAVQAIVEHKDATPAQRQIGEINTGILAVPGKRLADWLGRLSNDNAQGEYYLTDVIAMAVGDGLVVASAQPLDAMEVQGVNDRMQQAQLERHYQRLRAEELMRQGVTLLDPQRLDVRGEISVGRDVLIDVNVVLEGRVVIEDDVHIGPNCVIRDSVLRRGAVIKANSHLEGAELGEGSDAGPFARLRPGSVLGARAHVGNFVELKNARLGEGSKAGHLSYLGDAELGANCNIGAGTITCNYDGANKFRTELGDDVFIGSNNSLVAPLKIGDGATTAAGSTITHEVPAKNLAFGRARQKNLENWKRPEKIKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_STRA5
Sequence: MARIAGVDIPNDKRVVISLTYVYGIGLSTSKKILAAAGISEDIRVKDLTPDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNTKNNARTRKGKAVAIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: METZ_MYCTO
Sequence: MTDESSVRTPKALPDGVSQATVGVRGGMLRSGFEETAEAMYLTSGYVYGSAAVAEKSFAGELDHYVYSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVFTSLGALLGAGDRLVAARSLFGSCFVVCSEILPRWGVQTVFVDGDDLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELAHAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNAWVLLKGLETLAIRVQHSNASAQRIAEFLNGHPSVRWVRYPYLPSHPQYDLAKRQMSGGGTVVTFALDCPEDVAKQRAFEVLDKMRLIDISNNLGDAKSLVTHPATTTHRAMGPEGRAAIGLGDGVVRISVGLEDTDDLIADIDRALS
What is the function of this protein?
Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.
What are the official names of this protein?
O-succinylhomoserine sulfhydrylase, OSH sulfhydrylase, OSHS sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family. MetZ subfamily.