PharMolix/UniProtQA huggingface dataset:
Protein: WRIP1_HUMAN
Sequence: MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPGRKGSGKRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADADGEDDPGHWDADAAEAATAFGASGGGRPHPRALAAEEIRQMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHIIASNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEPAMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALTQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRNHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQEYLPEELRGVDFFKQRRC
What is the function of this protein?
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis.  In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased.  Also plays a role in the innate immune defense against viruses.  Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination.  In turn, RIGI transmits the signal through mitochondrial MAVS.
What are the official names of this protein?
ATPase WRNIP1, Werner helicase-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Colocalizes with WRN in granular structures in the nucleus.
Protein: ISPE_SERP5
Sequence: MIRQWPSPAKLNLFLYITGQREDGYHLLQTLFQFLDYGDTLTIDVRQDDAIHLLTPVAGVPDEQNLIVRAARLLQQHCDRHGLNTAPRGAEISIEKRLPMGGGLGGGSSNAATVLVALNDLWRCGLSDEQLAELGLALGADVPVFVRGHAAFAEGIGERLQPANPQEKWYLVAHPGVSIPTPVIFGDADLKRDTPVRPLNVLLQATYANDCEPIARKRFREVEQLVSWLLEYAPSRLTGTGACVFAEFDTETAARQVLNQAPEWIRGFVARGVNVSPLHRIRSGQIEP
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: GLPE_ECODH
Sequence: MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAVQAFHLTNDTLGAFMRDNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYX_NITWN
Sequence: MTDETFADRIDALEMRATYQEEAIETLNQVVTTQWKQIDALMRQIAEIGERLREAEAARPAPANEPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: IHFA_SALDC
Sequence: MALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPKEE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: SYI_FRAP2
Sequence: MSDYKDTLNLPKTSFSMKGNLANKEPMILNKWEKQGIYKKIREHFAGREKFVLHDGPPYANGSIHVGHAVNKILKDIIVKSKTLSGYDAPYIPTWDCHGLPIELQVEKKHGKAGQKISEDAFRKECRKYAKQQVEIQKKDFKRLGVLGQWDQPYLTMDFSYEANMIRTLAKIIENKHLTKGFKPVHWCTDCGSALAEAEVEYKDKISPAIDVKFKIKDKEKLAKAFGLESLNHDAFAIIWTTTPWTLPANQAIAVNNQLNYSLVKIEDFYIILAENLVEQTLKRYAIENAQVIANTSGYKLIGIIAEHPFYSRHVPILHGDHVTDDSGTGMVHTAPTHGVEDFTLGKEHDLSMEIFVKGNGCYSENTKLFAGEFVFKANDRVIELLGEKKRLMNFDKLKHSYPHCWRHKTPLIFRATPQWFISMEKEGLREKAIEAIKETSWAPSWGQARIEGMIKDRPDWCISRQRTWGVPLPLFIHKETEELHPNTIEILHKVAQKIEKGGIEAWFNADDNEFIAETDKYKRVKDTLDVWFDSGSSSMCILDIDKSLSYPADLYLEGSDQHRGWFQTSLLVAMSAKGNQPYKEVFTHGFVVDEHGRKMSKSLGNVTSPQDIYNTLGADILRLWTASTDYKSEMAVSDQILKRTADTYRRLRNTARFLLSNLEGFNPETDIIEFDKLVKLDQWAIAKTKEFQDKIIEAYDKYQTHTVAQLIHHFCSIEMGSFYLDIIKDRQYTAKADGHPRKSAQTAIYHIVHALVRWMAPILSYTADEIWEATPKTTDLPIQLCEWYTDLKSFNDQDELNLEFWAKIQEIRSEVNRILEIKRNEEVIKASLEAEIIIYADNDNYKLLEKLGNELRFLLISSKASLRAIEEKTNNSIESNITGLNIEVNKIEEPKCERCWHRSATVGQNEEYQDICSRCVENITTEAGESREFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYG_TETNG
Sequence: MGDFDMVLKFWGPVEADYSAHGGMVLTRLFTENPETQQLFPKFVGIAQSELAGNAAVSAHGATVLKKLGELLKAKGNHAAILQPLANSHATKHKIPIKNFKLIAEVIGKVMAEKAGLDTAGQQALRNIMATIIADIDATYKELGFS
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PURA_ECOUT
Sequence: MGNNVVVLGTQWGDEGKGKIVDLLTERAKYVVRYQGGHNAGHTLVINGEKTVLHLIPSGILRENVTSIIGNGVVLSPAALMKEMKELEDRGIPVRERLLLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADILTSMVVDVSDLLDQARQRGDFVMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGSGLGPRYVDYVLGILKAYSTRVGAGPFPTELFDETGEFLCKQGNEFGATTGRRRRTGWLDTVAVRRAVQLNSLSGFCLTKLDVLDGLKEVKLCVAYRMPDGREVTTTPLAADDWKGVEPIYETMPGWSESTFGVKDRSGLPQAALNYIKRIEELTGVPIDIISTGPDRTETMILRDPFDA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCF_SHEEP
Sequence: MKKTQTWIITCIYLQLLLFNPLVHTQGICRNRVTDDVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMVEQLSVSLTDLLDKFSNISEGLSNYSIIDKLVKIVDDLVECMEEHSFENVKKSSKSPEPRQFTPEKFFGIFNKSIDAFKDLEIVASTMSECVISSTSSPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKASNSIEDSSLQWAAVALPAFFSLVIGFAFGALYWKKKQPNLTRTVENRQINEEDNEISMLQEK
What is the function of this protein?
Ligand for the receptor-type protein-tyrosine kinase KIT.  Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.  KITLG/SCF binding can activate several signaling pathways.  Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1.  KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.  KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.  KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  KITLG/SCF acts synergistically with other cytokines, probably interleukins (By similarity).
What are the official names of this protein?
Kit ligand, Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand.
What is the protein family that this protein belongs to?
Belongs to the SCF family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium. Cell projection, filopodium. SUBCELLULAR LOCATION: [Soluble KIT ligand]: Secreted.
Protein: TNR8_MOUSE
Sequence: MSALLTAAGLLFLGMLQAFPTDRPLKTTCAGDLSHYPGEAARNCCYQCPSGLSPTQPCPRGPAHCRKQCAPDYYVNEDGKCTACVTCLPGLVEKAPCSGNSPRICECQPGMHCCTPAVNSCARCKLHCSGEEVVKSPGTAKKDTICELPSSGSGPNCSNPGDRKTLTSHATPQAMPTLESPANDSARSLLPMRVTNLVQEDATELVKVPESSSSKAREPSPDPGNAEKNMTLELPSPGTLPDISTSENSKEPASTASTLSLVVDAWTSSRMQPTSPLSTGTPFLDPGPVLFWVAMVVLLVGSGSFLLCYWKACRRRFQQKFHLDYLVQTFQPKMEQTDSCPTEKLTQPQRSGSVTDPSTGHKLSPVSPPPAVETCASVGATYLENLPLLDDSPAGNPFSPREPPEPRVSTEHTNNRIEKIYIMKADTVIVGSVKTEVPEGRAPAGSTESELEAELEVDHAPHYPEQETEPPLGSCTEVMFSVEEGGKEDHGPTTVSEK
What is the function of this protein?
Receptor for TNFSF8/CD30L (PubMed:8543792).  May play a role in the regulation of cellular growth and transformation of activated lymphoblasts.  Regulates gene expression through activation of NF-kappa-B (By similarity).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Lymphocyte activation antigen CD30.
What is the protein family that this protein belongs to?
Belongs to the TNFR8 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TULP_DROGR
Sequence: MLILRQLMDAYIRQKRASPGMVQASDLQMNRPMSGMRSNSRELHAYDGPMQFIGSPQNPDQILSNNSSSITMNSSRNNSNNMRSLSTINQEDLIEEISSHELEDEESSPVTVVEQPIAPQSANSAHSQRARIGQPSFNDTLDEEDYANRNISGVAAVRPAGIGSPYKEGAAMEGSNGAANGSGSVGGSGESEGDVIGQIDQFVMQPAPQGVLYKCRITRDRKGMDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVSCDPTDLSRNADGFCGKLRSNVFGTSFTVFDSGNKESTDSPRLDLAVIIYDTNILGFKGPRNMTVILPGMTEDDQRVKISSADPKQQGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLNFHGRVTQASVKNFQLVHDSDPEYIVMQFGRTSEDVFTMDYRYPLCAMQAFAIALSSFDGKIACE
What are the official names of this protein?
Protein king tubby.
What is the protein family that this protein belongs to?
Belongs to the TUB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BIOF_BORBR
Sequence: MSMSKLDSLFTAALEQAAQRQVRRRLRRATAAPPGRLALDGRTLVNFSSNDYLGLARHPLLAERASLWATRHGAGAQASRLVCGNLDLHEQVEAKLARLKGTEAALLLASGWQANAAVLPALFKAAAAQGEPQVYTDRLNHASLHHGCQAAGVRQIRFRHNDLAHLEHLLAERAGAPGARFIVTESVFSMDGDRADVPALAALAARHHAFLYLDEAHATGVLGPRGMGLAGLAPGGVDLAMGTFSKGLGSFGAYVAGSRALCDYLVNACSGFIYTTALPPAVLGAIDAALDLVPRLDQARAALLGHGERLRASLAAQGIDCGASSTQIVPAIVGDAGHALALAAELERRGLLAVAIRPPTVPAGTSRLRIALSAAHGEAELDQLIEALAAGWRAVRQAA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: YC7B_SCHPO
Sequence: MRNMVSEISDLSLAKEKSEAQFIARNPKSNDFHCKACDSLPGGNTRTVLHGAPFPIFIEAGYGSKLRDVDGHEYTDFLNELTAGIYGHSNPVIKKALMQGFDEIGISLGGTTTCELNYAEALKSRFLSIEKIRFCNSGTEANITAIIAARKFTGKRAVIAMHGGYHGGPLSFAHGISPYNMDSQDFILCEYNNSTQFKELVNSSQDIAAVIVEAMQGAGGAIPADKEFMQTIQLECEKNDIVFILDEVMTSRLSPGGLQQIYCLKPDLTTLGKYLGGGLPFGAFGGRADIMSCFDPRLPGSLSHSGTFNNDTLTLTAGYVGLTELYTPEAVKRLNALGDGLRKDIESYCHNTKMSITGLGSIMNIHFTESGRVNSYNDTAGEVIELKDLLWMDLLKEGFWIARRGMITLSLVLTESELEAFKLTIKAWIHRRMSLIRI
What are the official names of this protein?
Uncharacterized aminotransferase C417.11c.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NBP35_COCIM
Sequence: MAPSFEEPTVALGAASKAAPKLVAPEPEHCPGPESEQAGKGDACAGCPNQSICASAPKGPDPDIPIITARLSSIRHKILVLSGKGGVGKSTFTSLLANAFASNPDSTVGVMDTDICGPSIPKMMDVETETIHVSNAGWNPVWVSDNLAVMSVQFMLPNRDDAVIWRGPKKNGLIKQFLKDVEWGELDYLIVDTPPGTSDEHLSVNSFLKESGVDGAVLVTTPQEVSLLDVRKEIDFCRKAGIRILGLVENMSGFVCPKCTHESQIFKPTTGGGGRLAADMGIPFLGSVPLDPRVGMACDYGENFMDRYPESPASMALRKVVRTISRQVGEDPDEVLPETDAV
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NBP35, Nucleotide-binding protein 35.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIG_BRUA2
Sequence: MTETARTTIDASEIEHFSRIAAQWWDPQGKFRPLHKFNPTRLAYIKEKVCAKFNRDPNAPRPLEGLRFLDIGCGGGLLCEPMARLGATVIGADASATNIEVAKIHAAQSSLDIDYRATTAEALADAGEKFDVVLNMEVVEHVSDVDLFMSATSAMVKPGGLMFVATINRTLKAYGLAIIGAEYVLRWLPRGTHQYEKLVRPEELEAAFSKADLRLIDKLGVTYNPLADSWNRSRDMDVNYMVLAERPA
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: PTX4_MOUSE
Sequence: MRCLKKKTLLFLLIFVSLNVHRTPSQEAHPARQRKPFFERLRRLEEQFQRFQQVTLTHLQNIANNYNVYHNMDVRFQSLVEQSQAVALAMNQSQAAIQGDVAHLKTWYRKSQRRSRKVDARLQALDLSLSTKSRQWVEKEGEQKAQREAIASLALSVQALQDALASLTQQVHSQGARLAALEGQTQSASSGTVALGLTTAPTPTQLAQRGPGSLQLWRDRQVAKSSPQHRSSPHDVTVHVQEMQKFQTPSSHQAAPPRTYQGPGNICNTDPVLIFPNTSTENVIFLSPGFLMPLRALSFCSWVRMATSHLGTLLSYATKDNDNKLVLHGRNSLVPGSIHFVIGDPDFRELSLKPLLDGQWHHICIIWTSVEGKYWLHIDRRLVATGSRFREGYEIPPGGSLVLGQEQDTVGGEFDSSEAFVGSISGLAIWDRALLPREVANLASGKELPTGAILTLTNVTSVGGFVQRAKCTCLEQCP
What are the official names of this protein?
Pentraxin-4.
What are the subcellular locations of this protein?
Secreted.
Protein: RNFG_STUST
Sequence: MNELTQTPPVADGNEPPFTRPGLVETWRERVSYQALSLGLVCALVAVALLLGNQLTHQRIVDAERQDRLAVLRQVLPQALYDNDPLADAFNVEDAELGLIEVYPARRAGQLTATAFQISTVGYGGPIVQFIALDSEGRILGVRVLSHKETPGLADKIEVTRSDWIKAFDGLSLASTPLDQWAVKKDGGQFDQFAGATITPRAIVKGVLRALEFQARQSTAQSNQETRP
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit G, Rnf electron transport complex subunit G.
What is the protein family that this protein belongs to?
Belongs to the RnfG family.
Protein: PGM5_MOUSE
Sequence: MEGSPIPVLTVPTAPYEDQRPTGGGGLRRPTGLFEGQRNYLPNFIQSVLSSIDLRDRQGCTMVVGSDGRYFSRTATEIVVQMAAANGIGRLIIGQNGILSTPAVSCIIRKIKAAGGIILTASHCPGGPGGEFGVKFNVANGGPAPDVVSDKIYQISKTIEEYAICPDLRIDLSRLGRQEFDLENKFKPFRVEIVDPVDIYLNLLRNIFDFNAIKSLLTGPSQLKIRVDAMHGVMGPYVRKVLCDELGAPANSAINCVPLEDFGGQHPDPNLTYATTLLEAMKGGEYGFGAAFDADGDRYMILGQNGFFVSPSDSLAIIAANLSCIPYFRQMGVRGFGRSMPTSTALDRVAKSMKVPVYETPAGWRFFSNLMDSGRCSLCGEESFGTGSDHLREKDGLWAVLVWLSIIAARKQSVEEIVRDHWAKYGRHYYCRFDYEGLEPKATYYIMRDLEALVTDKSFIGQQFAVGSHIYSIAKTDSFEYVDPVDGTVTKKQGLRIIFSDASRLIFRLSSSSGVRATIRLYAESYERDPSGHDQEPQAVLSPLIAIALKISQIHERTGRRGPTVIT
What is the function of this protein?
Component of adherens-type cell-cell and cell-matrix junctions.  Has no phosphoglucomutase activity in vitro.
What are the official names of this protein?
Phosphoglucomutase-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma. Note=Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments.
Protein: SECB_XYLF2
Sequence: MSDEITNGAAKPTEAISGPTFTIEKIYIKDVSFEAPNSPAVFNEAGQPELQLNLNQRVQRLNENAFELVLHVTLTCTAAGKTAYVVEVQQAGVFGLFGLDQHAIGVLLGTQCPNILFPYVRSLVSDLIQIGGFPPFYLQPINFDALYAETLRQRAQNEKEGSQISSQPAGNA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHKB1_HUMAN
Sequence: MAAAATAAEGVPSRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQLREELDRSSCGNVLFNGYLPPPVFPVKRRNRHSLVGPQQLGGRPAPVRRSNTMPPNLGNAGLLGRMLDEKTPPSPSGQPEEPGMVRLVCGHHNWIAVAYTQFLVCYRLKEASGWQLVFSSPRLDWPIERLALTARVHGGALGEHDKMVAAATGSEILLWALQAEGGGSEIGVFHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCNNGSIYYVDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGGVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLISVCADNNHVRTWSVTRFRGMISTQPGSTPLASFKILALESADGHGGCSAGNDIGPYGERDDQQVFIQKVVPSASQLFVRLSSTGQRVCSVRSVDGSPTTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQAPAGGLTEQELMEQLEHCELAPPAPSAPSWGCLPSPSPRISLTSLHSASSNTSLSGHRGSPSPPQAEARRRGGGSFVERCQELVRSGPDLRRPPTPAPWPSSGLGTPLTPPKMKLNETSF
What is the function of this protein?
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1.  Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
What are the official names of this protein?
SH3KBP1-binding protein 1, SETA-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the KCTD3 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: Y1776_AQUAE
Sequence: MSVKVGWDITHQEFTITDYYYFSILQREAEKAGIEIDEVNDWESLNKYDVIVFNYPEIPFTESEVKDVERWVWKDGKKVILAGYYKNEDRIADTCNTLARAFGMELNPDEVTDEVNNHNGDKYFVVTSKIRRYNKNDKNEVNVEKIVLACTASIKPIMPDTKIVARGEDTAKSNMGNYPLLIAEQIAPPSGGYFCLAGTCVFWDNYSITLYDNLNFSLNLLRHVPPSKGTKLTIGP
What are the official names of this protein?
Uncharacterized protein aq_1776.
Protein: CAV2_RAT
Sequence: MGLETEKADVQLFMADDAYSHHSVVDYTDPEKYVDSSQDRDPHQLNSHLKLGFEDLIAEPPTTHSFDKVWICSHALFEISKYVIYKFLTVFLAIPLAFIAGILFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVVIGPLCTSVGRIFSSVSMQLSHD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and, in response to insulin, is translocated to the nucleus in complex with MAPK1. Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. The CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. The Ser-36-phosphorylated form resides in intracellular compartments (By similarity).
Protein: TIG_GEOKA
Sequence: MSVKWEKLEGNEGVLTVEVDAEKVNKGLDAAFKKVVKNITLPGFRKGKVPRVLFEKRFGVEALYQDALDILLPEAYAKAVEEAGIEPVSMPEIDIEQMEKGKSLIFKAKVTVKPEVKLGQYKGLEVEKMDTTVTDEDVENELKRLQEDYAELVVKEDGTVENGDTVVIDFEGFVDGEPFEGGKAENYSLEIGSGTFIPGFEEQLVGMKAGEEKEIQVTFPDEYHAKQLAGKPATFKVKVHEVKAKQLPALDDEFAKDVDEEVETLDELKAKIRARLEEAKKNEAETALRNAVVEKAAANAEMDIPEVMIKNETDRMLREFDQRLQMQGLNLQLYYQFSGQDEASLREQMKEDAEKRVRAALTLEAIAKAENIEVTDEEVNKELEKMAEAYKLSVDKLKELLGSLDGVKEDLKWRKTVDFLVEHSKVAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: M2_I68A6
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: YIDC_NEIMF
Sequence: MDFKRLTAFFAIALVIMIGWEKMFPTPKPVPAPQQAAQQQAVTASAEAALAPATPITVTTDTVQAVIDEKSGDLRRLTLLKYKATGDENKPFILFGDGKEYTYVAQSELLDAQGNNILKGIGFSAPKKQYSLEGDKVEVRLSAPETRGLKIDKVYTFTKGSYLVNVRFDIANGSGQTANLSADYRIVRDHSEPEGQGYFTHSYVGPVVYTPEGNFQKVSFSDLDDDAKSGKSEAEYIRKTPTGWLGMIEHHFMSTWILQPKGRQSVCAAGECNIDIKRRNDKLYSTSVSVPLAAIQNGAKAEASINLYAGPQTTSVIANIADNLQLAKDYGKVHWFASPLFWLLNQLHNIIGNWGWAIIVLTIIVKAVLYPLTNASYRSMAKMRAAAPKLQAIKEKYGDDRMAQQQAMMQLYTDEKINPLGGCLPMLLQIPVFIGLYWALFASVELRQAPWLGWITDLSRADPYYILPIIMAATMFAQTYLNPPPTDPMQAKMMKIMPLVFSVMFFFFPAGLVLYWVVNNLLTIAQQWHINRSIEKQRAQGEVVS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.