PharMolix/UniProtQA huggingface dataset:
Protein: MAO1_PECAS
Sequence: MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTEEERADFNLAGLLPEAVETIEEQAERAWRQYQEFKHDIEKHVYLRNIQDTNETLFYRLLDGHLNEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNRANIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRITDDEYYAFVDEFIQAVKRRWPNVLLQFEDFAQKNATPLLNRYRDEICSFNDDIQGTAAVAIGSLIAASRAAGTQLRDQTVAFLGAGSAGCGIAEQIIAQMKSEGLSEEEARARVFMVDRFGLLTDKLPNLLDFQSKLVQKSELLADWDCNSDAISLLEVVRNAKPTIMIGVSGQPGLFTEEIIREMYKHCARPIVMPLSNPTSRVEARPEDIIRWTEGSALVATGSPFSPVHYQDKVFPIAQCNNSYIFPGIGLGVLASGANRITDGMLMAASRALADCSPLANNGEGALLPDLSDIQQVSKRIALDVGKAAQLQGVAVVTSADALQKAIDHNFWQPQYRSYKRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: NOS1_RABIT
Sequence: MEEHVFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGVASETHVVLILRGPEGFTTNLETTFTGDGTPKTIRVTQPLGAPTKAVDLSHQPPSAGKEQPRPVDGAAGPGSWPQPTQGHGQEAGSPSRANGLAPRTSSQDPAKKSGWAGLQGSGDKNELLKEIEPVLTLLAGGSKAVDGGGPAKAETRDTGVQVDRDFDAKSHKPLPLGVENDRVFSDLWGKGSAPVVLNNPYSEKEQPPASGKQSPTKNGSPSKCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMFPSQHTRRPEDIRTKEQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHIKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRSRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPCFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFRCALMEMRHPNSLQEERKSYKVRFNSVSSYSDSRKSSGDGPDVRDHFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPGLTQGLSSVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANQMVKVELLEERNTALGVISNWKDEPRLPPCTVFQAFKYYLDITTPPTPLQLQQFASLASNEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPIHHGVCSSWLNRIPADEVVPCFVRGAPSFRLPRNPQVPCILVGPGTAFAPFRSFWQQRQFDIQHKGMSPCPMVLVFGCRQSKIDHIYREEALQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAEQVYRALKEQGGHIYVCGDVTMAADVLKAVQRIMAQQGKLSAEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
What is the function of this protein?
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.  In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.  Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity).
What are the official names of this protein?
Nitric oxide synthase, brain, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS.
What is the protein family that this protein belongs to?
Belongs to the NOS family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
Protein: RLMH_METFK
Sequence: MKLRIISVGHKMPDWVQSACTEYTKRMPREMNVEIVEIKPDKRASGKNAEAVQEAEAKRILEAAGRDYLVALDEHGQEVTTLQLADKMRGWMESGRDVSLVIGGADGLHDSLKHKADWLWSLSKLTMPHGMVRVMLSEQLYRGLSVINNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y170_UREPA
Sequence: MMKRNELKQLQELQLKINDFYTLVMTTKNLDLCNLSALLEFLGINWGVWVNLSTQRDEFNKKRYEYITKANYGLRMALNELLGRNASYDKEINNQGLRKFRTQEYFKRLDFELANEQKSTDIEDTTITFEKVDDNNKLTIKKLINVI
What are the official names of this protein?
Uncharacterized protein UU170.
Protein: KPRS_CAUVC
Sequence: MKLLSGNSNRPLSQAIAEYLDMPLTRAQVRRFADLEVFVTIDENVRGEDVFVIQSTSYPANDNLMELLICIDALKRASGKRITAVIPYFGYARQDRKTGGRTPISAKLVANLITRSGADRVLTMDLHAGQIQGFFDIPTDNLLPSRLMAEDIRRHYPMGDDLMVVSPDVGGVVRARALAKRLDDADLAIVDKRRSGPGQSEVMNIIGDVKDRRCILFDDIADSAGTLCNAAQALMAHGAKSVSAYITHGVLSGAAADRVANSVLTELVVTDSIEASDPAKACPKIRYVSCAPLIGEAIRRIANEESVSKLFD
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR7_MAGST
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQILYRAVKKIQQKTETNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPIEIGSTQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TM100_HUMAN
Sequence: MTEEPIKEILGAPKAHMAATMEKSPKSEVVITTVPLVSEIQLMAATGGTELSCYRCIIPFAVVVFIAGIVVTAVAYSFNSHGSIISIFGLVVLSSGLFLLASSALCWKVRQRSKKAKRRESQTALVANQRSLFA
What is the function of this protein?
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10.  Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons.  Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.
What are the official names of this protein?
Transmembrane protein 100.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.
Protein: METK_SYNE7
Sequence: MTRRYLFTSESVTEGHPDKICDQISDTILDALLTEDPSSRVAAEVVVNTGLVLITGEVSTQAQTNLIDLARRKIAEIGYTGEDSGFGANNCTVLIALDKQSPDIAQGVDTAQEQRQASSDERFDSIGAGDQGIMFGYACNEAPELMPLPISLSHRLARQLAVVRHNGQLDYLRPDGKTQVTIAYEDGKPVAIDTILISTQHKAAIGDISDDNAVQERIKSDLWEQVVLPVFSDLVIQPDSATRFLVNPTGKFVIGGPQGDAGLTGRKIIVDTYGGYSRHGGGAFSGKDPTKVDRSAAYACRYVAKNIVAAGLAEKCEVQLSYAIGVARPVSVLVETFGTGKVADEVLLDLVRKHFELRPAGIIEHFNLQRLPGERGGRFYQEVAAYGHFGRNDLDLPWEQTDKADTLRQEALATTQA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGG_KLEP3
Sequence: MMKMRWLSAAVMLSLCTSSAWAFSIDDVAKEAKTLAGKGYEAPKSNLPSAFRDMKYADYQQIQFNHDKAYWNNQKTPFKLEFYHQGMYFDTPVTINEVTATSVRKIKYSPDYFNFGNVQHDKDTVKDLGFAGFKVLYPINSKDKNDEIVSMLGASYFRVLGQGQVYGLSARGLAIDTALPSGEEFPRFREFWIERPKATDKRLTIYALLDSPRATGAYRFVIMPGRDTVVDVQSKVYLRDKVGKLGVAPLTSMFLFGSNQPSPTLNYRPALHDSNGLSILAGNGEWIWRPLNNPKHLAVSSYAMENPQGFGLLQRGRQFSRFEDLDDRYDLRPSAWITPKGDWGKGKIELVEIPTNDETNDNIVTYWTPDQLPEPGKEMNFKYTITFSRDEDKLHAPDNAYVMQTRRSTGDVKQSNLIRQPDGTVAFIVDFTGADMKKLPADTPVAAQASTGDNAEIVENTVRYNPVTKGWRMILRLKVKDPKKTTEMRAALVNGDDTLSETWSYQLPANE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RLMH_CAMJ8
Sequence: MQVNIFCIQKSDEFKTWSEKYSKLISKYATLKEINVFNKKIALAQNLNAIEAKKSYEEAFMPYKKGYCIALDEKGKDLTSIEFAKLIQDKNELSFFIGGAYGLREEFNQSLDFRLSLSKLTLAHQFVKTLLLEQIYRAFCINNNHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDCII_DICDI
Sequence: MDSNAAEKSSKEIIEDLQRQLLTEKNRNRTLVEELKQLRDSHARIQIVTENEEEYITNKFMKYLNQLKKEKEELALKVEQEEEYLTNTLQKKMLTIMKEKVDLENQLEQEEEFIVNKLQKQIQDVMKDKKALEKRLENEINDHRSLLKLQDEVIVLRDKIKELESNGNKKEDIDALKAENFVLGQKIIREQEKLSKVNSENTKLMSNLEIDDERNFNNKSKRNRSISFPTSMASTTTTTTTSITSSTTSITSSTSSINSSGSSSTNNTCNNNSSSNIPTSPLSCSSNSSGGGGGSGSLNNSCNSNCSNSSNSSNNNCNNNNNNNNGNSKLSTGVPITRSRSSSSNSNPCLITKIVKEGWLKRKSISSSNQETLEKRYYEISTDGEMREYFDETKQIPTSQYINLDTCFQIDIVTDNPNHPGYSDIKLYIKTNSISPVEIITFSTSSNDCNDWKDTISSLMPLKR
What are the official names of this protein?
PH domain-containing rcdII.
Protein: RS13_BURCM
Sequence: MARIAGVNIPNHQHTEIGLTAIFGIGRTRSRSICSAAGVEFSKKVKDLTDADLEKLREEVGKFIVEGDLRREVTMNIKRLMDLGCYRGVRHRKGLPMRGQRTRTNARTRKGPRRAAQALKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: THIO_MOUSE
Sequence: MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHSLCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEASITEYA
What is the function of this protein?
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
What are the official names of this protein?
Thioredoxin, Trx, ATL-derived factor, ADF.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway.
Protein: YQ7B_SCHPO
Sequence: MLIVNRNPKSLVRGYCKKDIVLRNLDGWLFDMITISTIFKLYNQICSLSSTDRKKTSISNKLQQEFCIMDINKVGRNFISLGKIRSSKRRNAILSYQTIISSFPHNHVQKLFQRTQSTNMIYTKLEYFGHSLFFYFTAFTLSFKDRKILMQADVFFRLKLVFKIAFFFTQTTFLNKKENREL
What are the official names of this protein?
Uncharacterized protein C1442.11c.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UBC17_CAEEL
Sequence: MSSQASQRSSSTSAVAQKTRERRKSKSRRRCWFGCLWLSSRVSLIRSSSRFSRSPEPDESLTAIDKVMSIINEKPLKMAHILKTARFVNDVSFSERKQFVECGVIHHLLELIGETAISDFSASSRSADEQKRRARRNSSASLSHKGTGYGTGSTRSRWDIERTVEEKLIREEHLTWLLSILNSFMLGWPTTDNLKTKPEELVHMTEIAIKLIADSSVLSILEYNLRNDSFFDVSEHIEIYQALLETAASMAATPGLVPFLVRPYTSSAKSIAKELIPRFKENILSIQARWGGTLEETNFRMAEFTAKVTLLSDYVINAARAYEQTLPPEQRIQTATHRRPSHSGLHSKMQGPKDDETIYKNKMQELQLQTAKFIGDFGKLCVPYVFRKEAKNINPFSPHLRDRTKRIAKELASIANALPLNASNSIYVCYDEGRVDIIKVLISGPDDTPYANGLFEFDIFFPTGYPFSPPKCAFLTTGSGNVRFNPNLYNDGKICLSILGTWEGRPEEKWNPYCSLMQVLVSIQGLIFVKDPYFNEPGFERYQGTDRGDEYSRKYNLQIEHATLNYAIREQLKKPSEHFKEVIEKHLWLKREAILKQAQAWIDNVSNDFGDDKMSKRKDVFAFETGFNPATQERVIHNLIQELQAMQSPFAKEEAEESERLKREQSEKEEKQKKEAAALAEIEREKRELELDFQRRRSSVLATHVAVIRTQPTGDYSVPSVNEPSTSS
What are the official names of this protein?
Probable ubiquitin-conjugating enzyme protein 17.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: NCALD_XENLA
Sequence: MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGNLTMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNRDGKLSLEEFIRGAKSDPSIVRLLQCDPSSAGRF
What is the function of this protein?
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.  Binds three calcium ions (By similarity).
What are the official names of this protein?
Neurocalcin-delta.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
Protein: CBRA_ECOL5
Sequence: MEHFDVAIIGLGPAGSALARKLAGKMQVIALDKKHQHGTEGFSKPCGGLLAPDAQRSFIRDGLTLPVDVIANPQIFSVKTVDVAASLTRNYQRSYININRHAFDLWMKSLIPASVEVYHDSLCRKIWREDDKWHVIFRADGWEQHITARYLVGADGANSMVRRHLYPDHQIRKYVAIQQWFAEKHPVPFYSCIFDNAITDCYSWSISKDGYFIFGGAYPMKDGQTRFTALKEKMSAFQFQFGKAVKSEKCTVLFPSRWQDFVCGKDNAFLIGEAAGFISASSLEGISYALDSAEILRSVLLKLPEKLNTAYRRATRKLRLKLFGKIVKSRCLTAPALRKWIMRSGVAHIPQLKDYPTRFTSPTSRM
What are the official names of this protein?
Protein CbrA.
What is the protein family that this protein belongs to?
Belongs to the CbrA family.
Protein: TLR1_HUMAN
Sequence: MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK
What is the function of this protein?
Participates in the innate immune response to microbial agents.  Specifically recognizes diacylated and triacylated lipopeptides.  Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852).  Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
What are the official names of this protein?
Toll-like receptor 1, Toll/interleukin-1 receptor-like protein, TIL.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
Protein: SHL2B_MOUSE
Sequence: MSQSSRLCSGYYSLNRSFVEPFQCPQRGDGAALLYCCGFADLKYCCSEPGSYFPYKHSYMWSLSIGALVGLGIAALVLLAFVISVCVLCYLFLYTKPQRLDNGLKLQHLETSSTLEGNINRKAKGLNAVSNSTNETFYEADDGTQEKTMDITQINIAC
What are the official names of this protein?
Protein shisa-like-2B.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: EFCB2_LOTGI
Sequence: MKVAVVLIVVLVVMMIGQETDSWRIRIRRGRKIFRKIRPYIPFVIGAVGKRQAGDAEFQAKYNAAAEDGVFTDEEIKSVFGVDDNGFVEFKATYDVDGDGVVQVEEYETVVELTENLAG
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 2.
Protein: RUBR_TREPA
Sequence: MGTYMCDLCGWGYNPEVGDADGGIPAGTAFENLPDHWECPLCGVDKTSFVKV
What is the function of this protein?
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide.  Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity).
What are the official names of this protein?
Rubredoxin, Rd.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
Protein: IF2_BACVZ
Sequence: MAKMRVYEYAKAINVSSKEILTALKNMDIVVNNHMAMLEEKTIKQLDAKFKKGGAGVTSQKPAETNKNKPQGINQQPAGNQPNKIRDGKKNDVQNNQFNKNKKNNNNNKNKNKRNHNNKNQYQQKPLKPKKELPEKITFSGSLTVGALAEELGKEPSELIKKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEADKEEDLQIRPPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGHAAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKVDKESANPDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQAKGTVIEAELDKGRGSVATLLVQTGTLNVGDPIVVGNTFGRVRAMVNDLGRRVKTAGPSTPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQIKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASASNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIEEIEAAMKGMLDPEYEEKVIGQVEVRQTFKVSKIGTIAGGYVTDGHITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKEVSQGYECGITIKKYNDIREGDIIEAYVMQEIERK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AN34A_RAT
Sequence: MLHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQNKARMVRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPAPPSPGVCTSPSEVQLQTAGGGRGLLSPRAQEEEEKRDVFEFPLPKSPDDPSPSEPLPKPPRHPPKPLKRLNSEPWGLVAPPQPVPPAEGRPGLERLAAEFNGLTLTGRPRLSRRHSTEGPEDPPPWAEKVTGGGPLSRRNTAPEAQESGLPSGLRQKLSRMESVELDTPGHFCPDSPESSRLSLERRRYSASPLTLPPAGSVSSPRQSQESLPGAVSPLSGRRRSPGLLERRGSGTLLLDHISQTRPGFLPPLNVSPHPPIPDIRPQPGGRAPSLPAPPHSGAPGSPRTKRKLVRRHSMQTEQIRLLGGFQSLGGPGEPGR
What are the official names of this protein?
Ankyrin repeat domain-containing protein 34A.
What is the protein family that this protein belongs to?
Belongs to the ANKRD34 family.
Protein: RS3_STRGG
Sequence: MGQKVNPHGFRLGITTDFKSRWYADKLYKDYVKEDVAIRRMMTKGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGELEKLTGKQVQLNILEVKNPEVDAQLVAQAVAEQLSSRVSFRRAMRKSMQSSMKAGAKGIKIQCGGRLGGAEMSRSEFYREGRVPLHTLRANVDYGFFEAKTTFGRIGVKVWIYKGDVKNIAEVRAENAAARAGNRPARGGADRPAGRGGRGGERGGRGRKPQQSPAAEAPKADAAAAPAAESTGTEA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RL3_DESAH
Sequence: MFKGMLGKKIGMTSIFAADGTLVPVTVVRFGPCVVTQVKAEKTDGYNALQLGFDERALAKCNKPKVGHFSKSGSTGFNVVREFRVENTDEFEVGQNIGLDGFAIGDKVNVSGTSKGRGFAGTIKRHGFSRGPETHGCRNHRKPGSIGCSAWPARVVKGRRMPGHMGVDRKTVKNLEIIDIRPDENLVMIKGPVPGWKTGLLEIRKAV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RUVB_PROA2
Sequence: MRDELLNTPTDPLEEKFEEQIRPSRLEDFSGQQRLTDNLRIFIAAARQRGEALDHVLFSGPPGLGKTTLAHIIASELGGGLKITSGPLLDKPGNLAGLLTSLQKGDVLFIDEIHRLTPAVEEYLYSAMEDFRIDILLDSGPSARSVQLRLEPFTLVGATTRAGLLTSPLRARFGISNRLDYYSAELLQRIIIRTATILGIAIDQQAADEIARRSRGTPRIANRLLKRARDFTQVAQSSVISLELARKTLAALEIDEDGLDDMDKKIILSLLQKFDGGPVGISSLAVSVGEEHDTIEEVYEPYLIQTGFIARTPRGRVATKNAYRKFLGVLPGDDGPLFQKGSS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL25_VIBVU
Sequence: MKFEAVVRTELGKGASRRLRLAGQFPAVVYGGEAAPVAVALNHDDIVNQMDKPEFYEAITLVIGGEEVKVKPQDVQRHAFKPKVEHMDFIRI
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: RL18_YERPY
Sequence: MDKKAARIRRATRARRKLKELGATRLVVHRTPRHIYAQVIAPNGSEILVAASTVEKAINEQLKYAGNKDAAAAVGKTIAERALEKGITKVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.