PharMolix/UniProtQA huggingface dataset:
Protein: F16PA_ACISJ
Sequence: MTERISLTRYLVEQQRVHGRIPPQLRLLVEVVARACKRISFAVNKGDLGDVMGTAGTENVQGEVQKKLDIIANEVLIEANEWGGHLAAMASEEMDGIYVVPNRFPQGEHLLMFDPLDGSSNIDVNVSIGTIFSVLHKHHDDPTTDEPVTEADFLQPGHQQVAAGYCIYGPQTTLVLTVGDGVAMFTLDREQGSFVLTRENIRIPEDTKEFAINMSNMRHWDAPVRRYIDECLQGKEGPRGKDFNMRWIASMVADVHRILMRGGIFMYPWDKREPNKPGKLRLMYEANPMGWLVEQAGGAATNGRQRILDIQPAQLHERVSVILGSKNEVDRVTSYHSGI
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KITH_AHV1W
Sequence: MASNSHNNYNTPRRQNYDVPKAWEEDSLYENIDFLTQPAVSSDTSEDEEPLLSVARRVEVQGVNPGLKPRGLVRPRQDADNPSSDEGFDWELWKLHLSTRAFSFLEPPRLSSSNTASGLRSSCSDFTILGSSGVNPTSHANLSEEEMYEEIPPLASNPSDERHPRQLSGAVAQGAIRKSPRKLKFKPAKFKGLSSSLLNPFTASDSGRRARRQTPTCQPGFTPIFQDLGEPHYVKACTVFFEGCMAAGKTTLLNFARQTLSDDEALTIPEPMRFWTEVYTNVLSQIVKINKECKPGKTSTTAELVSCQLKFATPLKTQSLFLQRSVKKDSEMQPVGPLDKWVIVDRHQLSALVVFPLVLMRRGMLSFSDFFNLLGMFEAHPGEVIALMSVNVEENFTRLKKRGRVCERHIDRDYIKEIKGSFNAAYCAWLFLQYFSIQTTMQICMGLSSLDEACATEGVCHTTASRIWNNRMLVTLSDIISQFSNDYTVQNVCYNFFSQLSTLKFVVIDLSAFRHDVPGAWGEFYMQVMKNGDIKTRVMDFTAIKALADTAHNTHLRSISFSSSQVFSTMLFLILLCVTGAQAITTPAPPRPATTTPRRGVTSAPLIVPASSSELIVTLDGTFHSVTIDMTEIRQYVRQEIIEALWNASHVFESLETTYNRYKDVYRFTDQSIRVNTRGSCQLVKK
What is the function of this protein?
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis.  The dTMP serves as a substrate for DNA polymerase during viral DNA replication.  Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae thymidine kinase family.
Protein: ABCGI_DICDI
Sequence: MENEEKREYLAKSRSNSRNFLNDSIESKNIFGVDKKSEPNLKQSIDGGLNFSTTSSYNPSNLPRTSVFVSARNLSSTVGHGKNEKKILTDLNFFLKPGSMVLLLGSPGCGKTSLMNTLALLTSNEKITGNLLFNGKTGDPNTHHRHVSYVVQDDFHMAPLTVRDTFKFSADCQSGDKSEKERIEIVDNVLDFLDLKHVQNTVVGDEFLRGISGGQKKRVTIGVELVKESNLLLMDEPTNGLDSSISLEMLTKIKNKVQQEKMSCLISLLQPGLEITKLFDYLMIMNQGQMSYFGPMNQAIGYFEGLGFKFPKHHNPAEFFQEIVDEPELYCGIDDGSSDGGSGDSGSSSGGSNYNYNFKNKASSTMMMMNNNNKIIPPLKGSDEFAMAYRKSIIYKHILEYIDSHIPDEEERSKFIDYSTTLKPYSTGFGRQLSLNVKRGFKLFLGNKASIRLRLLKNVIIGFILGTLYWKLDTTQADGSNRSGLLFFSLLTFVFGGFGSISVFFDQRQVFYSERAWKYYNTITYFLSMIVTDLPMSIVEVLIFSNFVYWMTGLNKTWDRFIYFFLTCLVCDVMSLSIIRSVCSFTKTKYAASAISPAVVSPFILMCGYMKHSNEIPGWWIWLYWISPIHYGFEGLLLNEHSGLDYHCSPDELMPPSFLPTFNTSYPVGFEGNQVCPITKGEQILDSIGFHTEFYYRWVDLAIISAFTLLFWLITLVCMKFLVFRVYRKDPVGIKKSKPNKTTTLIKMNRNSTDSTTTNNSMNYFNNKHNKKQNDDSDSGEEMESVDVDVKSSGKANLRKDIPIGCYMQWKDLVYEVDVKKDGKNQRLRLLNGINGYVKPGMLVALMGPSGAGKSTLLDVLANRKTGGHTKGQILINGQERTKYFTRTSAYVEQMDILTPVSTVREVILFSAKNRLPNSVPIQEKEEFVDNILETLNLLKIQHSLIGDVESGLSLSQRKRVNMGIELASDPQLLFLDEPTSGLDSSAALKVMNLIKKIASSGRSVICTIHQPSTTIFKKFDHLLLLKRGGETVYFGPTGTNSKIVLNYFAERGLICDPFKNPADFILDVTEDIIEIIQPPQTLPTSTSNENNNNNNNNNNNNNNNNNNNNNNNNNNNNGNTSDTLNNNNKKNLESSLSSSSISFDPVESFKESKENQKLLSIVENSIMPVGTPVAVYHGKYSSTIKTQFIELLKRSWKGGIRRVDTIRTRVGRSFVLGLVIGTLFLRLDKEQNDVFNRISFLFFSLMFGGMAGLSIIPTVSTERGVFYREQASGMYRVWIYYLTFVLSDLPFVIITSYAYVIPVYFLTGLSLSNHGWDFFYHSFISVMLYLNFGLTSIAFATSLPVEEMAFLLNGVLLSVTSLFAGFMIPPPSMPAAWKWAFYLDFISYPLKAFLITEFKDMEFVCTDNKGAIPIPIPSQNTTKFFCPITHGTQVLDRIDYKISFQYWDILIMASFTFALLVGGYLSLKFIRYQNK
What is the function of this protein?
Required for endocytosis and endosomal pH regulation.
What are the official names of this protein?
ABC transporter G family member 18, ABC transporter ABCG.18, ABC transporter mdrA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS14_LISMF
Sequence: MAKKSKVAKHERQQALVEQYAELRRTLKAEGRYDELRKLPRDSSPSRLHNRCELTGRPHGYMRKFGISRIRFRELAHQGQLPGVTKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: REC6_HUMAN
Sequence: MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGVPNSSEETATIENGP
What is the function of this protein?
Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript.  Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery.  This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts.
What are the official names of this protein?
Endogenous retrovirus group K member 6 Rec protein, Central open reading frame, c-orf, cORF, Endogenous retrovirus K protein 6, HERV-K(C7) Rec protein, HERV-K(HML-2.HOM) Rec protein, HERV-K108 Rec protein, HERV-K_7p22.1 provirus Rec protein, K-Rev, Rev-like protein, Rev/Rex homolog.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus.
Protein: ASSY_DELAS
Sequence: METILQNVPVGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEADYDEIPRKAMEYGAEQARLIDCRSQLAGEGIAAIQAGAFHISTGGITYFNTTPLGRAVTGTMLVAAMKEDDVNIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQTFIDELGGRAEMSAFMTKEGFGYKMSAEKAYSTDSNMLGATHEAKDLEFLNSGIRIVNPIMGVAFWKPEVEVKAEEVSVTFDEGRPVAINGKEIADPVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQYRINGLRLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPADRIGQLTMRNLDLMDTRDKLAIYAKAGLLSLGTSTALPQLGGKE
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_ACIBT
Sequence: MAKKIDGYIKLQVPAGKANPSPPIGPALGQRGVNIMAFCKEFNAATQKVEPGLPIPVVITVYNDKSFTFIMKTPPASILLKKAAGIQKGSSVPNKTKVGKLTRAQLEEIATTKEPDLTGADLDARVRTIAGSARSMGLEVEL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RL19_VIBCM
Sequence: MSNIIKALEQEQMKQDLPQFAPGDTVVVQVKVKEGDRERLQAFEGIVIAIRNRGLHSAFTVRKISNGEGVERTFQTHSPVVDSIEVKRRGAVRRAKLYYLRDLSGKAARIKEKLAKK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RPAC1_MOUSE
Sequence: MAAAQAVEEMRTRVVLGEFGVRNVHTTDFPGNYAGYDDAWDQNRFEKNFRVDVVQMDEDTLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPILADPRLFEYRNQGEEEGTEIDTLQFRLQVRCTRNPNAAKDSSDPNELYVNHKVYTRHMTWVPLGNQADVFPEGTIRPVHDDILIAQLRPGQEIDLMMHCVKGIGKDHAKFSPVATASYRLLPAITLLEPVEGEAAEELSQCFSPGVIEVEEVQGKKVARVANARLDTFSREIFRHEKLKKAVRLARVRDHYIFSVESTGVLPPDVLVSEAIKILMGKCRRFLDELDAVEMD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.  RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I and III subunit RPAC1, DNA-directed RNA polymerase I subunit C, RNA polymerases I and III subunit AC1, AC40, DNA-directed RNA polymerases I and III 40 kDa polypeptide, RPA40, RPC40.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYM_THEVO
Sequence: MIGIKILVNCALPYANGPLHVGHIAGAYLGADVFVRFNRLIGNEVLYVSGSDEYGTPITVRAEKEGKSPQEIADRYYAEHIETFKKLGINFDIFMRTTYPEHSSVAQEFFLKLLNEGVIEKGTMIAPYCRKIGRFMPDRYIEGECPYCGYKKARGDQCDNCGRTLDPQELINPVCILSGETPEFRETEHFFLRLDLFEERLEEWLKTKTFWKPNVLAYTRNFIQGGLKKRAITRDIDWGVKVPLEGYEHKRIYVWFEALIGYITGAKMFSEVIGKPNYWKEFYFDKDVKNYYFIGKDNIPFHSIIWPAMLLGYGELNLPYDIPANEYLTFKGEQFSKSRGIGYTVDELLRVIPPDYLRYYVASILPETGDSDFSLEELVKTVNSDLIDKYGNFVHRTLSFINKYDLKITKPNSLNDEAFEYAQNAFKEYCDELSQVHIKRSLAIWLNLAIYANSYFNKSEPWNLIKTDRDQCNYKLYVSLKLAQYLTAMIYPFTPTSAKAIWEQLGVNMDIDSSFSILNSINDFSVKPSRIPFEKLDIDKLKL
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAUB_PSEE4
Sequence: MALLELERISAQYPGASTPVLADINLSLGPRQLLVALGPSGSGKTSLLNLIAGFVAPSGGRITLDGAPVQGPGAERGVVFQDDALLPWQDVLANVAFGLELAGVPRAQREAKAREMLALVDLAGFAERRIWQLSGGQKQRVGLARALAADPRVLLMDEPFGALDAFTREQMQELLLQVWQRTAKPVFLITHDIEEAVFLATELVLLAPNPGRVVERLQLDFGQRYAAGESARAIKSDPRFIETREHVLARVFSQRQESA
What is the function of this protein?
Part of the ABC transporter complex TauABC involved in taurine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Taurine import ATP-binding protein TauB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL33_DICNV
Sequence: MAKKSVRELIRLVSSEGTGHFYTTTKNKRNTPEKMEVKKFDPVARKHCIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: NU120_CHATD
Sequence: MAFDNFEILYKETRLNLEPASPSSVVQLRVAPTNAYGRSSLSSSSSSRPASATADDEKGYRTKNLATASSIYYRKHHSSPRGFLWRVLDNNTVLSIRVADVCRQEKVADAPLILNLRFASPLRPACVGFADHEDHDALFVYAIDQSNQLWSIILRPDHFRKRSATEGGLGDASRVYSPPGFGFKHPHRLAVVSPDQLIVTMHDGGILKFDRNKNHESHGSPWRESIYNVAGWGQSLRGLVPFQRNPTVRYEKINMELTAAASTAVTTMGHAETAFLFTICLDHRMRVWDVRTGQILYTGDILNNTKRDPQEVGKWTVDPSQNNLIRILDNGRGQCLVVTYSPVGAGEFKFWKVKANDQGSIHVTDCFPDARLMSPNPTSLDVWTLADFAIAQQPDGPELWALWKNNTSYRVNRLQIIPRNATAPFADGWKAVCVESPGPTPRASGSWNPTDSTEKWLDLIFSPGRFSKSTLETALAMYEKGLGTYKETVSRSGKGIAESICSVIGSTTTLDRSSQGGADYDQFRNTSETQWMRFWRLLLELDKQRGEALSLVFDQYDGMVWVTCADLLAAVRQCSDLERLYHNLQSPEKKNEDVAALISAGLTFVETFSDSMHQLCKAALRAELYENSALSDRERMQLFLDRAGFWVTDEDWAQVLDIVGQNYQMVTSRLYEDLFDLITATSEANSQELREPFTIFGKKVVVRAVQETVELHWQILFSQLILLVNMVDSESEEARPLHTRFDVGSVYRRLIDALRRLEHLRWMTKTELSVSPSKSRSGSSSPTLSKRGQDESYTRTALEELAGHLFGLPESNNMPLLSSITDLVLDLCAPTSTTVLNTWLIQCWLLKEGRPDLALELMPFAEQDPFSTYVQGRVFLALRDYDTAAQHFRKAAIGLSIPLKHVDRHSAGLLDDTEWNLLNSGLPNYYAHIVNLYDKQKAYSYVMEFSRLALQFAQTSNQDSASIKTEMLSRLFTASTATSHFEEAHSALLAMDDEALQKSYLRKLLERMCESGQSSELISLPFSGLQNKVDEILAEKCRATRDVLNGVPYHQILYAWRISHNDYRGAAAILLDRLEKLRRSGEGDKLGAEDGENGAGNDALDTQVTRQYLIVINALSCVAPQEAYILEDVPPPVPGKGTNDEEYSQTGSKRKLGKLNATSGEEDLDSRIEELARLLDSESAGDKKARPSSSSEEDQQLLERMQKFSTAVRQEQGQQTPRRLLRLEDLRKQYQQELDRIVAIQNNQFALTADGEDEDEDMMDIA
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  NUP120 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.
What are the official names of this protein?
Nucleoporin NUP120, Nuclear pore protein NUP120.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Symmetric distribution.
Protein: HIS3_NITMS
Sequence: MDKTIDDIDFEKSGGLVPVIVQDANTKEVLTLAYSNRESLELAKKTRKSWFYSRSRNKLWMKGEESGNTQEIKEILVDCDSDAIIYLVEPSGPACHTGERVCFHNELK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_CROS8
Sequence: MSITKDQIIEAVSAMSVMDVVELISAMEEKFGVSAAAAVAVAAAGPAEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKSLEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: BRF2_HUMAN
Sequence: MPGRGRCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQVSRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAYRHSGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCLAELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSRTMQLVELANETWLVTGRHPLPVITAATFLAWQSLQPADRLSCSLARFCKLANVDLPYPASSRLQELLAVLLRMAEQLAWLRVLRLDKRSVVKHIGDLLQHRQSLVRSAFRDGTAEVETREKEPPGWGQGQGEGEVGNNSLGLPQGKRPASPALLLPPCMLKSPKRICPVPPVSTVTGDENISDSEIEQYLRTPQEVRDFQRAQAARQAATSVPNPP
What is the function of this protein?
General activator of RNA polymerase III transcription.  Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071).  Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071).  Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071).  Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071).
What are the official names of this protein?
Transcription factor IIIB 50 kDa subunit, TFIIIB50, hTFIIIB50, B-related factor 2, BRF-2, hBRFU.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACPS_CERS4
Sequence: MILGIGTDLANIDRMEKTLARFGERFRNRVFTPLEQAKAERRADVAGTYAKRWAAKEACSKALGTGLRMGIAWKDMSVANLETGQPVMRLTGWAAERLASMTPPGHEAVVHVSLTDDHPWAQAFVVIEARPRAAPPA
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_HALMA
Sequence: MAADAPHPAFEGYATEAVPQAAVGSPGKDGVLELTFERTADGTTLVHDYATVPFHISGTLGYDPLPEADTVFIQSPTGGVAQGDRHDVSITVGDEAVAHVSTQSSTKVQTMTCNYAAADTTLSVGAGGHLDYVPEPTILHADSRYLQELSVDLAPGATAVVSDVVVPGRLARGERFEFERYLSRVRATGPDGHLFEDATHLTPGDEDPTAPGVLGEFTVYGTTFVLAPDHDEAELSDALHAVVTDGDARAGATALPNGAGVAVRALGDRAETVQATLHAAWDHARIELLDAPAPSGRKY
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADJ_PECCP
Sequence: MNDQQPFSAITESPSAFSLTIRPDNIGVIGIDVPGEKVNTLKSEFAQQILSVFEQARQHATLRGLILISSKPDSFIAGADITMLNQCRSAEQAENLAKQGQETFEQIAALPFPVVAAIHGACLGGGLELALACDYRVCSLDEKTVLGLPEVQLGLLPGSGGTQRLPRLIGLDSALDLILTGRHLRANQALRQGLVDEAVPHDILLDTAVEMLKKGKRKAEPLGWRSRLLSSPGIRHVLFKMVKRKTRAKTHGNYPATEKIIQVVRRGVEKGREEGYRQEARAFGKLVMTPESAALRHLFFASNALKKTSGAASDAKPIHYVGILGGGLMGGGIASVTATRGQLPVRIKDINEQGINHALKYNWQLLTQRVQRKRMKPTERQRLMTLISGSTDYRGFEHADIVIEAVFEDLALKRQMVAEIEDHAAPHTIFASNTSSLPIHQIAEGARRPQQVIGLHYFSPVDKMPLVEVIPHAHTSAETVATTVALARKQGKTAIVVGDSAGFYVNRILAPYINEAAYCLLEGEPIESIDYALVRFGFPVGPFALLDEVGIDVATKIVPVLSEELGTRFTSPPAFDAILKDGRKGRKNGKGFYRYNKTRRFWQTGREVDSSIYPLLDVTAKAHIDPALISQRGVMMMLNEAARCLDEGVIQCARDGDIGAVFGIGFPPFLGGPFHYMDRLGMETVVKTLLVLQQQYGDRFAPCERLLAMREGQRTFYPPTDEDDSAS
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_CORA7
Sequence: MPELPEVESVRRGLEPYVVGRSFAAVEVHHPRANRGQEAPLSALLVGRKIAAVARRGKFMWLEFADEDHSDPARDVLFIHLGMSGQVRIGEVDSPHVRIAAVLDDTTRLSFVDQRTFGYWRLGPWLSMAHIAPDPLETDFDLTAAGRRLRAKRTVVKAALLDQTVLSGVGNIYADEALWAVQISPLKKASALRQRDAVAVISAAADVMRAALAVGGTSFDALYVNVNGESGYFDRSLHVYGRGGQPCERCGEEILKTVLGGRGTHYCPSCQNRGVGRKSAAN
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: FES_HUMAN
Sequence: MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
What is the function of this protein?
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading.  Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.  Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT.  Plays a role in the regulation of mast cell degranulation.  Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling.  Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR.  Phosphorylates BCR and down-regulates BCR kinase activity.  Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
What are the official names of this protein?
Tyrosine-protein kinase Fes/Fps, Feline sarcoma/Fujinami avian sarcoma oncogene homolog, Proto-oncogene c-Fes, Proto-oncogene c-Fps, p93c-fes.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
Protein: FMT_STRGC
Sequence: MTKLIFMGTPDFSATVLKGLLESDQYEVLAVVTQPDRAVGRKKEIRITPVKEVALSYGLPIYQPEKLSGSPEMEAIMNLGADGIVTVAFGQFLPSKLLARMNFVVNVHASLLPKHRGGAPIHYALIQGDKETGVTIMETVKEMDAGDMISRRSIPITDEDNVGTLFEKLAIVGRDLLLDTLPAYLSGDIQPEAQDPSQVTFSPNIRPEEERLDWNMTNRQLFNQIRGMNPWPVAHTLWQGERFKIYEAELADGEGQPGEILEIGKRQLLVATGEGALVLKTVQPAGKPKMTISDFLNGAGRNLAVGDKFGN
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.