PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_AERS4
Sequence: MKHIRNFSIIAHIDHGKSTLSDRLIQTCGGLSSREMQAQVLDSMDLERERGITIKAQSVTLNYQAQDGNTYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMELEVVPVLNKIDLPAAEPERVAEEIEDIVGIDAIDAVRCSAKTGLGVDLVLEEIVARIPAPVGDPDAPLQALIIDSWFDSYLGVVSLVRIKNGSLKKNDKIKVMSTGQVWGVDRIGIFTPKQVDTQGLGCGEVGWVVCGIKDIHGAPVGDTLTQAKNGAEKALAGFKKVKPQVYAGLFPISSDDYESFRDALDKLSLNDASLFFEPESSTALGFGFRCGFLGMLHMEIIQERLEREYDLDLITTAPTVVYEIELNDGSTIHIDSPSAMPPVNNIKEMREPIAECNILLPQEYMGNVITLCIEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYGFKRFETSEMVRLDIMINGERVDALAIITHKENAQYRGRQVVEKMRELIPRQMFDIAIQASIGNQIIARSTVKALRKDVTAKCYGGDVSRKKKLLNKQKEGKKRMKSLGRVDVPQEAFLAILHVGKD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HMP1_CAEEL
Sequence: MPANGNSHAYFNIDEVRSKNVLKQITQLINEVTNITETFPLKPGQTTEGLVATLDAAVANFLQTGSFAISKCPIANSDPRAIDLLHEALGAVQDTGQVMIQTGRDFVRDSTSTNKRAIATNSGRNLLTAVAKFLILADSIDVKVIVDKVDEVRETAHQMIEADTKIKVDDLYNLLISQIEELDITVRRRAIDLVKPNQRDDLLAARSALRQTAPLLYTSTRTFVRHPEHEEARRNRDYTADEMHSALNALESVLNGQQPKVTFSEYGRIGDLINEIDTFQNRIEIDPAHYRRGTDRPDLEGHCERIVSGSASIADAESTRENRKQKIVAECNNLRQALQELLTEYEKSTGRRDDNDDIPLGIAEVHKRTKDLRRHLRRAIVDHISDAFLDTRTPLILLIEAAKEGHEENTRYRSKMFQEHANEIVSVARLSCQLSSDVESVSVIQHTAAQLEKLAPQVAQAAILLCHQPTSKTAQENMETYKNAWFDKVRLLTTALDNITTLDDFLAVSEAHIVEDCERGIKGITANASTPDENAANCETVDCAAGSIRGRALRVCDVVDAEMDFLQNSEYTETVKQAVRILKTQRVDQFAERASALANRQEAHGLTWDPKTKEEEMNEFINACTLVHDAVKDIRHALLMNRSMNDVDSDVEYEADGVGAANADANRTISEQENQQNLMRRLPEEEKKKIQAQIDIFKVTQTRFEREVAKWDETGNDIISLANNMCKIMMSMTEFTRGCGPLKTTMDVIRAAQEISLNGSKLNALARQIGEESADSQTKKDLLAYLSQITLYCQQLNICSKVKADVTQVGNELVVSALDSAMSLIQTARNLLTAVVQTVKAAYIASTKFRRPNANSVRVEWRMAPPKKQPLIRPQKNNAIIRRASERRPLQPAKVLAEFTRNEIETGRDSDDEELDRRHQQRINGRL
What is the function of this protein?
Required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567).  Required for proper localization of other junctional components, such as pac-1 (PubMed:25938815).
What are the official names of this protein?
Alpha-catenin-like protein hmp-1, Protein humpback-1.
What is the protein family that this protein belongs to?
Belongs to the vinculin/alpha-catenin family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cytoplasm.
Protein: YACG_CHRVO
Sequence: MSESVRIVACPTCKAEVRWEPQSRYRPFCSERCRLIDLGQWASESYRVPAEEDHPPGETPPTH
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: IOVO_BRACA
Sequence: VATVDCSDYPKPACTVEYMPLCGSDNKTYGNKCNFCNAVVDSNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM_HAHCH
Sequence: MSGEPRKILVTSALPYANGPIHLGHLLEYIQTDIWVRFQKLRGHQCTYVCADDAHGTAIMLKAEQMGITPEQLIDQVNADHRRDFAEFLIEFDNYYSTHSEENRELSSYIYKACLDAGKIATRTITQAYDPEKNLFLADRFIKGTCPKCKAEDQYGDNCEVCSSTYTPAELINPRSAISGATPIEKESTHFFFKLPDFQEFLQKWTRSGTLQPQIANKLAEWLDAGLQEWDISRDAPYFGFEIPDQPGKFFYVWLDAPIGYMASFKNLCARRADLDFDEYWKKDSTAELYHFIGKDIINFHALFWPSMLSCADFRTPSAVYAHGFVTVDGAKMSKSRGTFIMARTYLEHLNPEYLRYYFAAKLTSNVDDLDLNLQDFTLKVNADLVGKLVNIASRCAKFITKAGGKLSPQISEPELIEQFLSKSDFIAQAYEDREFGKAVREIMALADLANKYIDEKAPWKLAKEEGKEQEVLDVCSVGVNLFRILITYLAPVLPGVAAASAEFLNAPIVWNRPLEPLTDHAVNEFKPMISRVDPKAVDAMVDASKDNMAQAPKDNGKAKKDKKEAKSEEEIAPTIKFDDFAKIDLRIAKIVSAEHVEGADKLLRLQLDIGSEQRQVFAGIKSAYAPEDLVGRLTVMVANLEPRKMKFGMSEGMVLAAGPGGKDIWLLQPDSGAQPGMQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMAH_MACMU
Sequence: MGSTEQTTEILLCLSPVEVANLKEGINFFRNKSTGKDYILYKSKSRLRACKNVCKHQGGLFIKDIEDLAGRSVRCTKHNWKLDVSTMKYINPPESFCQDELVVEMDENNGLLLLELNPPNPWDSEPRSPEELDFGEVQITYLTHACMDLKLGDKRMVFDPWLIGPAFARGWWLLHEPPSDWLERLCQADLIYISHLHSDHLSYPTLKKLAGRRPDIPIYVGNTERPVFWNLNQSGVQLTNINVVPFGIWQQVDKNLRFMILMDGVHPEMDTCIIVEYKGHKILNTVDCTRPNGGRLPTKVALMMSDFAGGASGFPMTFSGGKFTEEWKAQFIKTERKKLLNYKAQLVKNLQPRIYCPFAGYFVESHPSDKYIKETNTKNDPNELNNLIKKNSDVITWTPRPGATLDLGRMLKDPTDSKGIIEPPEGTKIYKDSWDFEPYLEILNAAVGDEIFLHSSWIKEYFTWAGFKDYNLVVRMIETDEDFNPFPGGYDYLVDFLDLSFPKERPQREHPYEEIRSRVDVIRHVVKNGLLWDELYIGFQTRLQRDPDIYHHLFWNHFQIKLPLTPPNWRSFLTCCEQNGPGISQECKTT
What is the function of this protein?
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions.  Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.
What are the official names of this protein?
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase, CMP-N-acetylneuraminic acid hydroxylase, CMP-N-acetylneuraminate monooxygenase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the CMP-Neu5Ac hydroxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SARZ_STAEQ
Sequence: MYVENSYLSKQLCFLFYVSSKEIIKKYTDYLKEYGLTYTGYIVLMAIEDDEKLNIKKLGERVFLDSGTLTPLLKKLEKKNYVIRTREEQDERNLQISLTERGKDIQNVLSDISQSVFNEFNITQEETQNLVEDLQNFVTKNFDKTVEK
What are the official names of this protein?
HTH-type transcriptional regulator SarZ, Staphylococcal accessory regulator Z.
What is the protein family that this protein belongs to?
Belongs to the SarZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTB7_CERBT
Sequence: MASSNRRVLVNGGGPAGAVTAFWLAKGGFEVVVTERSMSRPYGQGVDVTGRASDIIKKMGLEQRIRDSTTGEAGLTVVDDQGEDVAPPLGTAPIEGGTASVTQEIEIMRRDLTKIFVDAAEALPNVTFRYGCTVDEVQQHEKSITAVLSDTGKPEDFTAIIGADGLGSAIRKLTFDPEINRRSVSPTNTYVAFFSIPGDPKYDTPVGKLQHANKGRGILVRPIDKKGTQRSCYLMSQSDSQELAQVARTGSQEDQKALLDNRFREFTGPLGKRAVEGMHSADDFYFTRIVQIKLDSWHSGRAALVGDAGYSPSPLTGQGTTLAIIGAYVLAGEMAKSPDDLERAFTSYYAILNKFVSESQEIPFGGQAPKLILPQSDWGIWLLRTFYKIISWTGIWRLLNFGNETVKVELPEYDFGGLD
What is the function of this protein?
Monooxygenase; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin (By similarity).  The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules (PubMed:11701851).  These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids (PubMed:11701851).  The first step of cercosporin biosynthesis is performed by the polyketide synthase CTB1 which catalyzes the formation of nor-toralactone (By similarity).  The starter unit acyltransferase (SAT) domain of CTB1 initiates polyketide extension by the selective utilization of acetyl-CoA, which is elongated to the heptaketide in the beta-ketoacyl synthase (KS) domain by successive condensations with six malonyl units introduced by the malonyl acyltransferase (MAT) domain.  The product template (PT) domain catalyzes C4-C9 and C2-C11 aldol cyclizations and dehydrations to a trihydroxynaphthalene, which is thought to be delivered to the thioesterase (TE) domain for product release (By similarity).  The bifunctional enzyme CTB3 then methylates nor-toralactone to toralactone before conducting an unusual oxidative aromatic ring opening (By similarity).  The O-methyltransferase CTB2 further methylates the nascent OH-6 of the CBT3 product, blocking further oxidation at this site before the reductase CTB6 reduces the 2-oxopropyl ketone at position C7, giving naphthalene (By similarity).  The FAD-dependent monooxygenase CTB5 in concert with the multicopper oxidase CTB12 are responsible for homodimerization of naphthalene with CTB7 installing the dioxepine moiety, finally producing cercosporin (By similarity).  The fasciclin domain-containing protein CTB11 might act with CTB5 and CTB12 whereas the roles of CTB9 and CTB10 have still to be elucidated (By similarity).
What are the official names of this protein?
Monooxygenase CTB7, Cercosporin toxin biosynthesis cluster protein 7.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Protein: RFCL_METHJ
Sequence: MDWAEKYRPRHLNEMVGNREALHQMSEWATRWTVESPPLILYGKPGIGKTSSAWALAHDMNWEVVELNASDQRTKAVIEKVAGGSASTGSLTGAARKLIILDEADNLQGNADRGGARAIAEVIRQARQPLILIANDLYGLDGTIRNLCTKVQFKALPAKSLVPRLREICSREQLTCSAQALTDIAEQSGGDIRSAVTMLYASAIGKDTVGEDDVSISAKDSRASIFDLVAATLGYRQVPSLLDMSMSVDETPDTILQWIEGNLGVLPDRKKTAQAYAALSRADMYLGYTFLTQYYTLWRYATSVMLYGVHDVMKGRPSGYAKIMPPSRWRQMSVAKKQKTIREQLLSDMGTSMHMSASTVRNLYLCPISLLAKQFPEQFAKSYDLDVDKLDILIHDPATSKSIIKKIEDEKKQIEKELKKKKKEEDAKGKKARGSKKEKEPIVEETPSIDSFSSQEPGNPPEQPSTEPVEKDKKSSQSTLFSF
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C large subunit, RFC large subunit, Clamp loader large subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcL subfamily.
Protein: DNLJ_RALPJ
Sequence: MSKTEEPASGPPSKDRPEARAAWLRAELNRYAHEYYVLDQPSVPDVEYDRLYRELEALETEHPELKTPDSPTLRVGGAVLPEFAAVRHVIPMLSIRTETDTTANGARAFDASVRRELGLDDTDPPVEYAAELKFDGLAINLRYERGYLVQAATRGDGTTGEDVTQNIRTIRQIPLGLSPVDGHVPDVLEVRGEVYMRRDDFEKLNARQRERGDKTFVNPRNTAAGAVRQLDPKMAAERPLSFFAYGLGEVAGWKGMPGTHSSMLDVLQAFGFPVSNERAAVAGGEGLVRFHEAIRAKRDSLPFDIDGVVYKVNSLALQRELGFRSREPRWAVAHKYPAQEALTTVESIDVQVGRTGAITPVARLVPVFVGGVTVTNATLHNEDEVRRKDVRVGDTVIVRRAGDVIPEVVSVVLDRRPLDDVPGSDLFNPQQQPKYPPFELPKTCPVCGSHVVREEGEAVARCSGGLFCSAQRKEAIRHFAGRRMMDIEGLGERYIDNLVELDYVHGIADLYKLTLEDFLEMKRRADERDGVTPETVSAGKIATKWAENLLEGIQASKTPPLARFLFALGIRHVGESTAKTLADWLGSLAMIRRAPAPLLLALPDVGATVAEAIADFFAEPKNQQALDALLEAGVAPQGEHAPNAKLREKLEPAELYATLGVPKLTATRAKQLAVAAPTLAQLASVEPDQLAGLPADVTASLLEWLASHDHRAQLAKLDALRGELLAAMPAEAAEEGVLDGKTVVLTGTLPNLTRDEAKAMLEAAGAKVSGSVSKKTDYVVAGEDAGSKLAKAEELNVKVLDEAGMLALLKKPAGDQA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: MUG_ECOK1
Sequence: MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQLKPQEAQHLLDYRCGVTKLVDRPTVQANEVSKQELHAGGRKLIEKIEDYQPQALAILGKQAYEQGFSQRGAQWGKQTLTIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_OENOB
Sequence: MQNYKVTISYDGHYFEGFQTQNRPGSRTVQDELIKVVSKMAKTKIKVIGASRTDAGVHANGQVINFIFPFDLNEKAILMGMNSQLPTDILVKKVEKVPINFNARHSSHRKRYLYRVSTSKFIDPFKRFYTGHYFWNLDTNKIQEALPDLIGEHDFSSFAASGNQTATTIRTVTKAELKIFPKNNELLFTFEGNAFLYNQIRIMVGVLLEIGNGTRPVHDIIRLIKIKDRQQARFTAPASGLYLDEVYYESMD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: NADA_SYNY3
Sequence: MFTAVAPPQETLPRDLVGAIQSLKKELNAVILAHYYQEAAIQDIADYLGDSLGLSQQAASTDADVIVFAGVHFMAETAKILNPHKLVLLPDLEAGCSLADSCPPREFAEFKQRHPDHLVISYINCTAEIKALSDIICTSSNAVKIVQQLPPDQKIIFAPDRNLGRYVMEQTGREMVLWQGSCIVHETFSERRLLELKTQYPQAEIIAHPECEKAILRHADFIGSTTALLNYSGKSQGKEFIVGTEPGIIHQMEKLSPSKQFIPLPNNSNCDCNECPYMRLNTLEKLYWAMQRRSPEITLPEATMAAALKPIQRMLAMS
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_XYLFA
Sequence: MSNVNMDFEQAGELKIGQVGIATLRIRTLNVPRLIQEMSDRVTRAPKLFRRTAVILDFGELPHTPDLTTAKALVEGLRAANVLPVAIAYGTNEIDLLSQQLGLPLLSKFRAHYERQEVAAPPPQSTPPINTGRIQHTTVRSGQQLYAEHCDLTILNTVGAGAEVIADGNIHIYGTLRGRAMAGARGNAEMRIFCRDFQAELIAIAGRYKVLDDIPTELRGKAVQVWLEQNQIKIAALD
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization (By similarity).
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: CDIA9_BURPE
Sequence: SLDTTGNVDLTSANVKAGSLDLNAGNKLILDTATQTTHQVSRDGATSDKTTLGPAANLNVAGDASIKTGGDFQQNAGNLNVGGNLNANIGGNWNLGVQQTGEHKVVQRANGVSDTDLNSATGSTVNVGGKSAIGVGGDLTAQGARLDFGQGGTVAAKGNVTFGAASTTSTINANSSGDQGNRSYAETRHGADQALTGTTVKGGDTLNVVSGKDINVIGSTIDLKKGDANLLAAGDVNVGAATETHVYNSRETHSRSGVVSGTKIASSQDATSTVANGSLISADGVSIGSGKDINVQGSTVVGTHDVALNAAHDVNITTSQDTSQSSTTYQEQHSGLMSGGGLSFSVGNSKLAQQNQSSSVTNNASTVGSVDGNLTVNAGNTLHVKGSDLVAGKDVTGTAANIVVDSATDTTHQAQQQQTSKSGLTVGLSGSVGDAINNAISETQAARESAKDSNGRASALHSIAAAGDVAFGGLGAKALLDGAKGPQAPSIGVQVSVGSSHSSMQSSEDQTIQRGSSINAGGNAKLIATGNGTPKDGNITIAGSNVNAANVALVANNQVNLVNTTDTDKTQSSNSSSGSSVGVSIGTNGIGVSASMQRAHGDGNSDAAIQNNTHINASQTATIVSGGDTNVIGANVNANKVVADVGGNLNVASVQDTTVSAAHQSSAGGGFTISQTGGGASFSAQNGHADGNYAGVKEQAGIQAGSGGFDVTVKGNTDLKGAYIGSTADASKNSLTTGTLTTSDIENHSHYSANSAGFSAGASVGVSTKAVGPSSVSGSGGVTPMVFQNDSGDQSATTKSAVSVGAINITKPGEQTQDVANLNRDATNLNGTVSKTPDVQKMLSQQADTMNAAQAAGQTVSQGIGLYADGKRKDAIDAAKAAYERGDLVAMQSYIDQAKSWDEGGASRAGLQATGGALIGGLGGGSVLTAIGGAAGAGTSSLLAGQAEKISKSVGDMTGSSLVGNIAANVAATVGGALVGGSAGAAMASNVELYNAGNDPQKTDDRATIAGLQGLLSRTAAMASDAKAGVWNGMVNVAGVIVNIPNGGPFASPGDPGYVSLDGLKKPYKSGTSIGPDTEFLTPILATLGLGGKAAVGTDAGITSADVATVGNGALKNASGDLSAAANSARNQPYGQGASASQSPGTQGASSGSNISASNGSSSPTTIVASNPVDLNAFDRLNVVDPAVGKFRPGEAGAAAELENYLGGTLQRAPQGSSVDFVFSSGPNNGKTVDFMLTPDTVAQAAKINQFFDKNLNNFMNTLSDHAAAADFVPLDSRFLSEANKTLLVKAIGNLPQKLQAKIILIK
What is the function of this protein?
The CdiA protein is thought to be exported from the cell through the central lumen of CdiB, the other half of its two-partner system (TPS).  The TPS domain probably remains associated with CdiB while the FHA-1 domain forms an extended filament with the receptor-binding domain (RBD) at its extremity; in the secretion arrested state the C-terminus of the RBD domain form a hairpin-like structure as the FHA-2, PT and CT domains are periplasmic.  Upon binding to a target cell outer membrane receptor a signal is transmitted to activate secretion.  The filament elongates slightly, the rest of CdiA is secreted and the FHA-2 domain becomes stably associated with the target cell's outer membrane where it facilitates entry of the toxic CT domain into the target cell periplasm.  From there the toxic CT domain is cleaved and gains access to the target cell cytoplasm via an inner membrane protein.
What are the official names of this protein?
tRNA nuclease CdiA, CdiA-E479, Toxin CdiA.
What is the protein family that this protein belongs to?
Belongs to the CdiA toxin family.
What are the subcellular locations of this protein?
Target cell, target cell cytoplasm. Note=Secreted to the cell surface by CdiB, its two partner secretion pathway (TPS) partner.
Protein: VU2_HHV6Z
Sequence: MFCRSPFLGISSWSLASAALCPSSCSFPAGRDLRCDAAVPEVKWTAFVRTLVARPLSADDVRDFVSTFAHCRLALSWPVGAELRFATSDMLGITQAELAKLSRGYGCCPGMDLTVIGVTIFAEVSALVLVGECGEIYAFNGVFDDALYRLAEDAFGLWKHGLRRFEPVYGSKCLMETGASFFGGMSGVDDALAFAVSFDKALVPLPWPRGAFFEFAVPRRAEKRWRLIPGGGVAVVIGRFFGRGVTLPLLRRQRVLMDQVGRVYAASLDGGAVVRLSDSFRAFLAMGVRKLFKNHRFPPGHLWTMQLPVTCVHAPVINLPAVYQLSPHMVEREMSAVSCGASTVVRRDCEDTLRDGDAGVDTS
What are the official names of this protein?
Protein U2.
Protein: ENGB_STAA2
Sequence: MKVNPNNIELIISAVKEEQYPETELSEVALSGRSNVGKSTFINSMIGRKNMARTSQQPGKTQTLNFYNIDEQLIFVDVPGYGYAKVSKTQREKFGKMIEEYITKRENLQLVIQLVDLRHDPTQDDILMYNYLKHFDIPTLVICTKEDKIPKGKVQKHIKNIKTQLDMDPDDTIVSYSSIQNNKQQQIWNLIEPYIS
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: PSMG2_DICDI
Sequence: MNKFFYSIDNNNNNISFKNHTLIWPSLTLGNIGQLTIDVLICSFEFKRIGFIVDENITPIIGNDCFTTLDNNNGIMSTSIEVYQSSLFPSITLVQQRSPIVDGRIPNFSENLFKWINAEEIKEILFLSSSNANKRVDSQLTGSQVRFIKSDNVDKNIISKLNEMNISEMELTVQSPEGETIQLSNRLTGLAKEIYSTINSKNNDNNNKVSFLCLNLFCSEGYNTNEALQMSNLIYNFIKNQESPSSPQLKTPSCWKLLQGPTFDQSLFF
What is the function of this protein?
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg1.
What are the official names of this protein?
Proteasome assembly chaperone 2.
What is the protein family that this protein belongs to?
Belongs to the PSMG2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSLO_STAAB
Sequence: MTHDYIVKALAFDGEIRAYAALTTETVQEAQTRHYTWPTASAAMGRTMTATAMMGAMLKGDQKLTVTVDGQGPIGRIIADANAKGEVRAYVDHPQTHFPLNEQGKLDVRRAVGTNGSIMVVKDVGMKDYFSGASPIVSGELGEDFTYYYATSEQTPSSVGLGVLVNPDNTIKAAGGFIIQVMPGAKDETISKLEKAISEMTPVSKLIEQGLTPEGLLNEILGEDHVQILEKMPVQFECNCSHEKFLNAIKGLGEAEIQNMIKEDHGAEAVCHFCGNKYKYTEEELNVLLESLA
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3P1_SYNY3
Sequence: MLKIGINGFGRIGRLVARIAMANPQVTLVGINDLVPASNLAYLFKYDSTHGSYGGTVVAKEEGIVIDDQFIPCFSQRNPAQLPWGDLGADYVVESTGLFTTYATAENHLKAGAKRVIISAPSKDPEKIPTFVVGVNHLNYNADTDKIVSNASCTTNCLAPIAKILDDNFGIVEGLMTTVHAMTATQPTVDGPSKKDFRGGRGAAQNIIPSSTGAAKAAALVLPQLKGKLTGMAFRVPTPNVSVVDLTFKTEKATSYEEICAAMKTAAEGELKGILGYTADDVVSMDFRTDPRSSIFDAGAGIGLNSNFFKVVSWYDNEWGYSCRVIDLMLTMASKDGLV
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 1, GAPDH 1, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YA00_PYRHO
Sequence: MRTWKMRKDGQRIDYLGRKWRNLGGPFMEVSRVVTWIIIITLVALAIKTILPFFSPLFFAFITAYALYPLHIKLKERIGSKNSAILLTLFLLLGALMILLILVYTLTPVIGQAYDYLTNLEKIKINIPLVPKSVISSLEGVIDEFIERGKGYLVSLTFSVPKYLLQVIVYLTFVYFFLVKEKEARELITFEDEKLIRIIERGNLTLQALIRVWLLLNIVKGILMTLGFLIFKVSNLPTAILAGLLTVLFSFIPLFEGWMIWLAGAFYLVKQGHIIAGIGLAVYGFTLVSPLPDFTIRPKLVAREAEFNDVLVLIGMIGGTWGLGLKGLIIGPIVLNVAIEMLREWKNVQAKTERS
What are the official names of this protein?
Putative transport protein PH1000.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HGXR_TRIFO
Sequence: MTETPMMDDLERVLYNQDDIQKRIRELAAELTEFYEDKNPVMICVLTGAVFFYTDLLKHLDFQLEPDYIICSSYSGTKSTGNLTISKDLKTNIEGRHVLVVEDIIDTGLTMYQLLNNLQMRKPASLKVCTLCDKDIGKKAYDVPIDYCGFVVENRYIIGYGFDFHNKYRNLPVIGILKESVYT
What is the function of this protein?
Essential in nucleic acid metabolism of T. foetus because the parasite is unable to synthesize purine nucleotides de novo and relies on the HGXPRTase activities for its purine requirements by salvaging purine bases from the host.  Works with guanine, hypoxanthine and xanthine.
What are the official names of this protein?
Hypoxanthine-guanine-xanthine phosphoribosyltransferase, HGPRT, HGXPRT, HGXPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.