PharMolix/UniProtQA huggingface dataset:
Protein: SWP70_CHICK
Sequence: MVGLKEELLKAIWHAFTALDLDRSGKVSKSQLKVLSHNLCTVLNVPHDPVALEEHFRDDDEGPVSNQGYMPYLNKFILEKVQGNFDKVEFNRMCWTLCAKKNLSKSPLLISDEDAFKVWVIFNFLSEDKYPLIIVPEEVEYLLKKLTEAMGAGWQQEQFDLYKIALNTSREGLSAWELIDLIGSGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMLKKGHKRKNWTERWFVLKPNIISYYVSEDLKDKKGDIILDGNCCVEPLPDKDGKKCLFLIKCLDKSFEISASDKKKKQEWIQAIQTTVSLLRAGSPPPHKEARQKRKELRQKLLAEQEELERQMKELQTANENKQKELETVRKQLEAAAARAAEEEKKRLQTQVELQDRFSLELEREKMVRQKMEEQVAQKSSELEQYLQRVRELEEMYKQLQEALEVEKQARQDEETVRKLQARLLEEESAKRAELEKWHLQQQQTIQMTEAEKQELENQRMIKEQALQVAMQQLEQLELERKEALEQYEEVKKKLETAANNTRSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEQRQKSWKGKKASSE
What is the function of this protein?
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC.  It also mediates signaling of membrane ruffling.  Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
What are the official names of this protein?
Switch-associated protein 70, SWAP-70.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class- switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia (By similarity).
Protein: Y3206_ARATH
Sequence: MMSLLPNPDPITVPLVLKLCSFPPPRRLFSLRLRRFTRKSSSLLPLVAVSSLSATAAKPTRWREKPELAESDSISLLNERIRRDLGKRETARPAMDSEEAEKYIHMVKEQQERGLQKLKGIRQGTKAAGDGAFSYKVDPYSLLSGDYVVHKKVGIGRFVGIKFDVPKDSSEPLEYVFIEYADGMAKLPLKQASRLLYRYNLPNETKRPRTLSRLSDTSVWERRKTKGKVAIQKMVVDLMELYLHRLRQKRYPYPKNPIMADFAAQFPYNATPDQKQAFLDVEKDLTERETPMDRLICGDVGFGKTEVALRAIFCVVSTGKQAMVLAPTIVLAKQHYDVISERFSLYPHIKVGLLSRFQTKAEKEEYLEMIKTGHLNIIVGTHSLLGSRVVYSNLGLLVVDEEQRFGVKQKEKIASFKTSVDVLTLSATPIPRTLYLALTGFRDASLISTPPPERIPIKTHLSSFRKEKVIEAIKNELDRGGQVFYVLPRIKGLEEVMDFLEEAFPDIDIAMAHGKQYSKQLEETMERFAQGKIKILICTNIVESGLDIQNANTIIIQDVQQFGLAQLYQLRGRVGRADKEAHAYLFYPDKSLLSDQALERLSALEECRELGQGFQLAEKDMGIRGFGTIFGEQQTGDVGNVGIDLFFEMLFESLSKVEELRIFSVPYDLVKIDININPRLPSEYVNYLENPMEIIHEAEKAAEKDMWSLMQFTENLRRQYGKEPYSMEIILKKLYVRRMAADLGVNRIYASGKMVVMKTNMSKKVFKLITDSMTCDVYRSSLIYEGDQIMAELLLELPREQLLNWMFQCLSELHASLPALIKY
What are the official names of this protein?
ATP-dependent DNA helicase At3g02060, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RSMH_MYCA1
Sequence: MKHSATSSEAHARATWPLPEPTLAYFPNARFVPSDRDLDAGAARPIRGGVAVVDDSPDFGHVPVLLERCVELLTPALTRRHPDGSGAVLLDATLGAGGHAERFLTDLPGLRLIALDRDPSALEIARERLARFADRITLVHTRYDGIAAALTESGYAATESVDGILFDLGVSSMQLDRPERGFAYAQDAPLDMRMDPGSPLTAADILNTYDEAELADILHRYGEERFARRIAAQIVRRRAKEPFTSTADLVSLLYQAIPAPARRTGGHPAKRTFQALRIAVNDELDTLRCALPAALDALAVDGRIVVLAYQSLEDRIVKRLFAQAVASRTPVDLPVELPGHEPRFRALTHGAGRADAAEIERNPRSAAVRLRALQRTQAPQATGKGD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUV1_GORGO
Sequence: MLATRRLLSWSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGALSRGDWYKTKEILLKGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREILRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFSGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWENLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQARQAAS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, Complex I-51kD, CI-51kD, NADH-ubiquinone oxidoreductase 51 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I 51 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RRF_BACHK
Sequence: MGQQVLKSSNEKMEKAVAAYSRELATVRAGRASASVLDKVQVDYYGAPTPVVQLANITVPEARLLVIQPYDKTSIGDIEKAILKADLGLNPSNDGTVIRIAFPALTEERRRDLVKVVKKYAEEAKVAVRNVRRDGNDDLKKLEKAGEITEDDLRGYTEDIQKETDKYIAKVDEIAKNKEKEIMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRK2_HUMAN
Sequence: MKLIVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLSSPQKFARAHGVSVQPEASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRRSTRNYTVPDPPGLFDGHVWPMYQKYRQEMEANGVEVVYLDGMKSREELFREVLEDIQNSLLNRSQESAPSPARPARTQGPGRGCGHRTARPAASQQDSM
What is the function of this protein?
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).  Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin.  Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation.  May play a role in the regulation of terminal myogenesis.
What are the official names of this protein?
Nicotinamide riboside kinase 2, NRK 2, NmR-K 2, Integrin beta-1-binding protein 3, Muscle integrin-binding protein, MIBP, Nicotinic acid riboside kinase 2, Ribosylnicotinamide kinase 2, RNK 2, Ribosylnicotinic acid kinase 2.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family. NRK subfamily.
Protein: TRHO_RHIEC
Sequence: MTDSLIHTGPFLVAALYHFVSVPRFASLQAPLQALSEENGVKGTLLLAHEGINGTIAGPDAGIHAVLAFLRAQPEFARLEHKESRASKMPFLRMKVKLKKEIVTMGVEDIDPNKVVGTYVAPRDWNALISDPDTIVIDTRNDYETAIGTFRGALDPKTKTFREFPDWVRRNTGLHNKPKVAMYCTGGIRCEKATAFMKAEGFDEVYHLKGGILKYLEEVPQEESLWEGACFVFDERVSVEHGLKEGEHRLCHACRNPITSEEITSPLYEEGVSCSHCYHTRTEEDRLRYRQRQLQIALARKRGQRHIGS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: NDUA4_MACFA
Sequence: MLRHILGLAKKHPSLIPLFVFLGTGATGATLYLLRLALFSPDVCWDRNNPEPWNKLGPNDQYKFYSVNVDYDKLKKERPDF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.  NDUFA4 is required for complex IV maintenance.
What are the official names of this protein?
Cytochrome c oxidase subunit NDUFA4.
What is the protein family that this protein belongs to?
Belongs to the complex IV NDUFA4 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: DPO3_LACP3
Sequence: MALSQHEMFEKLLDQLDLAADVRQDPSLTSGTVQNVTIHEQSRRYDFTLGFDAILPFQTFNAIATKLPLVFQQIAATDLSVVVTQPTITDELLAQYWQYVVTHAEIGTGIVRELCEKQVPTLENDRAVIKTENEQIRQYLIQQGLGKLEETYRQVGFSGLRMQAEVDEEQAAQSMAAFQAQRAEETAKMAKAAAEVVKQQAAKQKQVQTDGPVQMGRQMKMTDAPQQMVTITQEERSVTVEGYVFDVEVRELRSKRQLLIFKVTDYSSSFIAKKFSNGPEDEAMFARIQKGQWLRVRGSVQEDNYSRELTINAQDIQTVSHPDPTDDAEGEKRVELHLHTNMSQMDAMNPISDYVKRAKEWGHKAIAVTDHAGLQAYPEAHSAAVKAGLKMLYGVEINLVDDGTPVAYRADEPRDLASAEYVVFDVETTGLSAVYDKVIELAAVKMKDGKVIDQFEEMIDPGFPLSELTINLTHITDDMVHGSKSEVDVFKLFQQFCDGAIMVGHNVTFDVGFLDNGYERHGLADIDNPVIDTLELSRMLHPERKNHKLDTLAKQYKVSLEHHHRANADAEATGYLLYALEKEAAKMYGMTTLNQLNDRVGAGDAYKAARPSHAIVFAKTQAGLKNLFKLVSLSNVKYFYRVPRVPRSQLQKLREGLLVGSACSNGEVFTAMMQKGEAEARAKASFYDYLEVQPLPVYQPLIEAGLIKGEAHLKDIIQKIIKIGSELEKPVVATGDAHYLDQHDAIYRQILIHSQGGANPLNRHSLPDVHFRSTSEMLTDFSWLGEEKAHELVVDNSNLIANWVDDDITPVKDKLYTPEVPGVEENLKHDVMTTAHELYGDPLPDIVAQRLDKELKSIIGNGFSVIYNIAQRLVLKSNKDGYLVGSRGSVGSSLAATMAGITEVNPLPPHYRCPNCQYSEFFTHGEIGSGFDLPDKQCPKCGADLHKDGHDIPFETFLGFHGDKVPDIDLNFSGDYQPIAHNYIKVMFGEDHSFRAGTIGTVADKTAYGYVKAYERDTGQQLRGAEIDRLAQGDTGVKRTTGQHPAGILIVPADMDIYDFTPIQYPADDQNAAWMTTHFDFHSIHDNILKMDVLGHDDPTMIRMLQDLSGVEPKSIPTDDPGVMALFSGTKSLGVTPEQINSKMGTLGIPEFGTRFVRGMLEETKPTTFSELLQISGLSHGTDVWLGNAEELIKQGIVTLKEVIGCRDNIMMDLIHWGMEDSMAFNIMEHVRKGRGIPDDWQKAMRENENVPDWYIESCLKIKYMFPKAHATAYILMALRIAWFKVHYPLIYYTAYFSVRAEDFDLAAMSHGKEAVKAAMKEITDKGMDASTKEKQLLTVLEIANECLERGFKIKMIDVTKSDSHNFLIQDDHTILAPFRAVPGLGDNVAKQIVAAREEKPFLSKEDLANRGKVSKTLIDYMTTNHVLDDLPDENQLSLFDGLF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLF_ARATH
Sequence: MASEASPSSSATRSEPPKDSPAEERGPASKEVSEVIESLKKKLAADRCISIKKRIDENKKNLFAITQSFMRSSMERGGSCKDGSDLLVKRQRDSPGMKSGIDESNNNRYVEDGPASSGMVQGSSVPVKISLRPIKMPDIKRLSPYTTWVFLDRNQRMTEDQSVVGRRRIYYDQTGGEALICSDSEEEAIDDEEEKRDFLEPEDYIIRMTLEQLGLSDSVLAELASFLSRSTSEIKARHGVLMKEKEVSESGDNQAESSLLNKDMEGALDSFDNLFCRRCLVFDCRLHGCSQDLIFPAEKPAPWCPPVDENLTCGANCYKTLLKSGRFPGYGTIEGKTGTSSDGAGTKTTPTKFSSKLNGRKPKTFPSESASSNEKCALETSDSENGLQQDTNSDKVSSSPKVKGSGRRVGRKRNKNRVAERVPRKTQKRQKKTEASDSDSIASGSCSPSDAKHKDNEDATSSSQKHVKSGNSGKSRKNGTPAEVSNNSVKDDVPVCQSNEVASELDAPGSDESLRKEEFMGETVSRGRLATNKLWRPLEKSLFDKGVEIFGMNSCLIARNLLSGFKSCWEVFQYMTCSENKASFFGGDGLNPDGSSKFDINGNMVNNQVRRRSRFLRRRGKVRRLKYTWKSAAYHSIRKRITEKKDQPCRQFNPCNCKIACGKECPCLLNGTCCEKYCGCPKSCKNRFRGCHCAKSQCRSRQCPCFAADRECDPDVCRNCWVIGGDGSLGVPSQRGDNYECRNMKLLLKQQQRVLLGISDVSGWGAFLKNSVSKHEYLGEYTGELISHKEADKRGKIYDRENCSFLFNLNDQFVLDAYRKGDKLKFANHSPEPNCYAKVIMVAGDHRVGIFAKERILAGEELFYDYRYEPDRAPAWAKKPEAPGSKKDENVTPSVGRPKKLA
What is the function of this protein?
Polycomb group (PcG) protein.  Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes, mainly abscisic acid (ABA) responsive elements (PubMed:17881378, PubMed:30307069).  Required to regulate floral development by repressing the AGAMOUS homeotic gene in leaves, inflorescence stems and flowers (PubMed:17881378).  Together with ATX1, modulates AG nucleosome methylation statement (PubMed:17881378).  Regulates the antero-posterior organization of the endosperm, as well as the division and elongation rates of leaf cells.  PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.  PcG proteins are not required to initiate repression, but to maintain it during later stages of development.  Forms a nuclear complex with EZA1/SWN and HXK1 to target common glucose-responsive genes and regulate glucose signaling by glucose-mediated gene repression (PubMed:35394700).  Affects the recruitment of HXK1 to the target chromatin (PubMed:35394700).
What are the official names of this protein?
Histone-lysine N-methyltransferase CLF, Polycomb group protein CURLY LEAF, Protein INCURVATA 1, Protein SET DOMAIN GROUP 1, Protein photoperiod insensitive flowering.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRHP_HELPY
Sequence: MNQVELLSPAGNLKKLKIALNYGADAVYGGVSHFSLRNRAGKEFTLETFKEGIDYAHALNKKVYATINGFPFNSQLKLLEEHIDKMAELEPDAFIIAAPGVVKLALKIAPHIPIHLSTQANVLNLLDAQVFYDLGVKRIVCARELSLNDAIEIKKALPNLELEIFVHGSMCFAFSGRCLISALQKGRVPNRGSCANDCRFDYEYYVKNPDNGVMMRLVEEEGVGTHIFNAKDLNLSGHIAEILSSNAISALKIEGRTKSSYYAAQTTRIYRLAVDDFYHNTLKPSFYASELNTLKNRGFTDGYLMRRPFERLDTQNHQTAISEGDFQVNGEITEDGRFFACKFTTTTNTAYEIIAPKNAAITPIVNEIGKIYTFEKRSYLVLYKILLENNTELETIHSGNVNLVRLPAPLPAFSFLRTQVRV
What is the function of this protein?
Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis.
What are the official names of this protein?
tRNA hydroxylation protein P.
What is the protein family that this protein belongs to?
Belongs to the peptidase U32 family.
Protein: D27_ORYSJ
Sequence: METTTLVLLLPHGGAGGVRPAAAATAKRSYVMRRCCSTVRAVMARPQEAPASAPAKKTETAAMMSTVQTETAAAPPATVYRDSWFDKLAIGYLSRNLQEASGLKNEKDGYESLIDAALAISRIFSLDKQSEIVTQALERALPSYILTMIKVMMPPSRFSREYFAAFTTIFFPWLVGPCEVMESEVEGRKEKNVVYIPKCRFLESTNCVGMCTNLCKIPCQKFIQDSLGMKVYMSPNFEDMSCEMIFGQQPPEDDPALKQPCFRTKCVAKQNHGVNCSI
What is the function of this protein?
Involved in strigolactones biosynthesis by catalyzing the isomerization of the C9-C10 double bond in all-trans-beta-carotene leading to 9-cis-beta-carotene and providing the substrate for CCD7.  Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signals that stimulate hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds.
What are the official names of this protein?
Beta-carotene isomerase D27, chloroplastic, Protein DWARF-27.
Protein: DCD_ECOK1
Sequence: MRLCDRDIEAWLDEGRLSINPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDEVSAALDRVMSDEIVLDESEAFYLHPGELALAVTLESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAARPYNRREDAKYRNQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: Y9147_DICDI
Sequence: MHQSQPQQQIEEYKQIKKLLFLVGLTIGKMATSRILSFLGFINCEIKLK
What are the official names of this protein?
Uncharacterized transmembrane protein DDB_G0290911.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IYD_HALH1
Sequence: MKQKPAFIPYAGAQFEPEEMLSKSAEYYQFMDHRRTVREFSNRAIPLEVIENIVMTASTAPSGAHKQPWTFVVVSDPQIKAKIRQAAEKEEFESYNGRMSNEWLEDLQPFGTDWHKPFLEIAPYLIVVFRKAYDVLPDGTQRKNYYVQESVGIACGFLLAAIHQAGLVALTHTPSPMNFLQKILQRPENERPFLLVPVGYPAEGAMVPDLQRKDKAAVMVVY
What is the function of this protein?
Catalyzes the dehalogenation of halotyrosines such as 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:24153409, PubMed:28157283).  Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity).  Activity towards 3-iodo-L-tyrosine is much stronger than activity towards 3,5-diiodo-L-tyrosine and 2-iodophenol (PubMed:28157283, PubMed:24153409).
What are the official names of this protein?
Iodotyrosine deiodinase, Halotyrosine dehalogenase.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family.
Protein: RIPR2_BOVIN
Sequence: MLVGSQSFSPGGPNGIIRSQSFAGFSGLQERRSRCNSFIENSSAVKKPQAKLKKMHNLGHKNSSPPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKLTTQLKDMRRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKMKQAFATSPASKAARESLAEINRSYKEYTENMCAIEAELEKQLGEFSIKMKGLAGFARLCPGDQYEIFMKYGRQRWKLKGRIEVNGKQSWDGEEMVFLPLIVGFISIKVTELKGLATHLLVGSVTCETKELFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDMTPSSGAGNKVAALQRRMSMYSQGTPETPTFKDHSFFSNLPDDIFENGKAAEEKMPLSLSFSDLPNGDCTLAPGPADSLPGACAANPEITITSTELPPGSQSSQNEGLKDSSSASCSSSSREGSEPRPHPEGETQGLGKPEGCPVATGARPERLFLQKGVAEALLQEALLQEPSELKPVELDTFEGNITKQLVKRLTSAEVPAATERLLSEGSISAESEGCRSFLDGSLEDAFNGLFLALEPHKEQYKEFQDLNQEVMHLDDILKCKPAVSRSRSSSLSLTVESALESFDFLNTSDFDEEEDGDEVCNVGGGADSVFSDTETEKNSYRSVHPEARGHLSEALTEDTGVGTSVAGSPLPLTTGNESLDLTIIRHLQYCTQLVQQIVLSSKTPFVASNLLEKLSRQIQVMEKLSAVSDENIGNISSVIEAIPEFHKKLSLLSFWTKCCTPIGVYHSSADRVIKQLEASFARTVNRDYPGLADPVFHTLVSQILDRAEPLLPASLSSEVITVFQYYSYFTSHGVSDLESYLNQLAKQVSVVQTLQSLRDEKLLQAVSDLAPGSFPAPQEEVLRTLALLLTGEDSGASEAVTLYLTAASRSEHFREKALLYYCEALTKTDFRLQKAACLALKSLKATESIKMLVTLCQSDTEEIRNVASETLLSLGEDGRLAYEQLDKFPRDCVKVGGRLASEVATAF
What is the function of this protein?
Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization.  Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation.  Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration.  Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion.  Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear.  Plays a role for maintaining the structural organization of the basal domain of stereocilia.  Involved in mechanosensory hair cell function.  Required for normal hearing.
What are the official names of this protein?
Rho family-interacting cell polarization regulator 2.
What is the protein family that this protein belongs to?
Belongs to the RIPOR family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, filopodium. Apical cell membrane. Cell projection, stereocilium. Cell projection, stereocilium membrane. Note=Localized in the cytoplasm in cells undergoing mitosis. Colocalized with F-actin. Accumulates at the leading edge of polarized neutrophils in a chemokine-dependent manner. Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region. Detected in punctate pattern forming a circumferential ring at the stereocilia base. Localized to the apical stereocilia of inner and outer hair cells.
Protein: TOFU6_CAEEL
Sequence: MASSSTAYYLKDAGFHIRNIPKAWNDWNLFHVFQNFGKVSYCRVVGQSNDGQVQLGFVNMMSVADADEVRKNLNDGNLIGENFTLKVTDHKNVGGSLLPMASNSVQKLVSSPPSKSGPVLLSSSWLPLNKDIEVEVVDYLPSSSVAPDLFALTLLRINDSSMKEKYDSMHEKMNAYAQIVPFDSELEIGYDGVFRDAPRSVRRVRRISATKLYLVDFGKIINYEKAKCFQLPKVFQSMPTRVSLCGLDGLTWSPVAIPSFDNIREVVKKWGQMENSTLHAMACGFQGSINMINLFCGKSILADRLQRKGVCEYLPRSQQPHYAYSRETLLQHNNSGVTAQISNDADVVKDLLKKIDGVKNMLRELEL
What is the function of this protein?
Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475).  Promotes the biogenesis of 21U-RNAs (PubMed:31216475).  Required for chromosome segregation and cell division in early embryos (PubMed:17171368, PubMed:31216475).  May have a role in DNA replication (PubMed:17171368).
What are the official names of this protein?
Embryonic developmental protein tofu-6, 21U-RNA biogenesis fouled up protein 6, Maternal effect lethal protein 47.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Dispersedly distributes throughout the cytoplasm in early embryos (PubMed:31147388). During early embryogenesis, localizes to the nucleus at prophase of cell division, and remains in the cytosol at interphase in 2- and 4-cell embryos (PubMed:31216475). Does not localize to cytoplasmic granules in oocytes and embryos (PubMed:31216475). Localizes to puncta in the perinuclear region in the germline syncytium (PubMed:31147388, PubMed:31216475). Localization to the perinuclear region in the germline is dependent on pid-1, tost-1, pics-1 and erh-2 (PubMed:31216475).
Protein: PDXJ_CHLL3
Sequence: MRLAVNIDHIATLRNARNEGEPDPVAAALLAEESGAAGIVCHLREDRRHIRDNDLKGLRRSVKTKLDLEMAMTEEMQRIAIETVPELITLVPEKREELTTEGGFDIERHFKRLALFIEPIRAAGIEVSLFIEPDSRSIDLAAEAGSDLVELHTGSYALKSGEEQTAEFERIRHAAKYAVDRGLKVVAGHGLNYRNIQPFRQIPEIEEVSIGHALIARAAFVGIPEAVREMLDLIG
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHS4_BROFI
Sequence: MAPAMEEIRQAQRAEGPAAVLAIGTSTPPNALYQADYPDYYFRITKSEHLTELKEKFKRMCDKSMIKKRYMYLTEEILKENPNICAFMAPSLDARQDIVVTEVPKLAKEAAVRAIKEWGHPKSRITHLIFCTTSGIDMPGADYQLTRLLGLRPSVNRFMLYQQGCFAGGTVLRLAKDLAENNAGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAIIVGSDPDSATERPLFQLVSASQTILPESEGAIDGHLREIGLTFHLLKDVPGLISKNIQKCLLDAFKPLGVHDWNSIFWIAHPGGPAILDQVEIKLGLKAEKLAASRSVLAEYGNMSSACVLFILDEMRRRSAEAGQATTGEGLEWGVLFGFGPGLTVETIVLRSVPIAGAE
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 4, Naringenin-chalcone synthase 4.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: PURA_TROWT
Sequence: MPATILIGAQWGDEGKGKATDLLAKDIDYVVKFNGGNNAGHTVVIGGDKYVLHLLPSGILNENVVPVIANGVVINPEVLFDEIATLNSRGVNTDKLVISANAHIIAPFHRTIDLVTERFLGKRQLGTTGRGIGPTYADKINRIGIRVQDLFDKSVLRQKIEGSLSNKNHMLVKVFNRRSVSVTEMLDYLLSFAERMRPMIADTSLLLNNALDCGKHVLFEGGQATMLDVDHGSYPFVTSSNATVGGAITGAGIGPTRVNKVIGVAKSYTTRVGAGPFPTELHDEYGEWLQKRGYEVGATTGRKRRCGWFDGVVARYATRINGITDYVLTKLDVLTGLDRIPICVGYKVGDSVFREMPVSQSDFHHAVPIYEDLPGWQCNISECESFDSLPPEARGYVLALEDLIKARISVIGTGPERENIIIRHPLGIF
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.