PharMolix/UniProtQA huggingface dataset:
Protein: SSUB_PSEPK
Sequence: MTVLKEQPPRLLRGTPLASKGLRKTFGQREVLKGIDLHIPAGQFVAIVGRSGCGKSTLLRLLAGLDQPTAGQLLAGAAPLEEAREETRLMFQDARLLPWKKVIDNVGLGLSGDWRPRALEALDAVGLADRANEWPAALSGGQKQRVALARALIHQPRLLLLDEPLGALDALTRIEMQQLIERLWRQHGFTVLLVTHDVSEAVAVADRVILIEDGEVGLDLTVDLARPRARGSHRLAALESEVLNRVLSTPGTAPEPDPVAPLPTQLRWAH
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NADE_AQUAE
Sequence: MLNLTLAQLNFTVGDVEGNKEKILKVIDEYSEKSHIIAFPELSLSGYPPEDLLLQPHFLKECEKAFDQIIHHTRNYDVIVAVGLPYYEFDLYNALAVIHRGEVLGIYKKHFLPNYSVFDEYRYFRKGEEPLMIEVNGHKVSFSICEDIWYPDGVERQTALSGAELIVNVNASPYHVNKYSFKESFLKSRAEDNLCFVAYVNLVGGQDELVFDGRSIVISPFGKLVARAKAFEEDILTVTLDLGEAKRKRLLDLRWREGSYGREKVNVKRSVSLPDKEFFRGRIEENPKEEEEIYAALKLSLRDYVRKNGFEKVVLGLSGGIDSSFVACLAVDALGRENVKGVYMPSQFSSKESYEDAKALAQNLGIEFHVIPIKEIYRAYFNEFEKEICEITFDVADENIQARIRANILFYFSNKFRYLVLSTSNKSETAVGYTTIYGDMAGGFAPIKDVYKTWVYKLARYRNSISPDIPERVFKKPPSAELRPNQTDQDVLPPYEILDQILMLYIEENLSPEEIIRKGLPRDAVYKTINMIRKNEYKRKQAPIGPKITSRAFGKDWRMPVTNKFFK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses L-glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine-dependent NAD(+) synthetase, NAD(+) synthase [glutamine-hydrolyzing].
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD synthetase family.
Protein: NFT1_CAEEL
Sequence: MLSTVFRRTMATGRHFIAVCQMTSDNDLEKNFQAAKNMIERAGEKKCEMVFLPECFDFIGLNKNEQIDLAMATDCEYMEKYRELARKHNIWLSLGGLHHKDPSDAAHPWNTHLIIDSDGVTRAEYNKLHLFDLEIPGKVRLMESEFSKAGTEMIPPVDTPIGRLGLSICYDVRFPELSLWNRKRGAQLLSFPSAFTLNTGLAHWETLLRARAIENQCYVVAAAQTGAHNPKRQSYGHSMVVDPWGAVVAQCSERVDMCFAEIDLSYVDTLREMQPVFSHRRSDLYTLHINEKSSETGGLKFARFNIPADHIFYSTPHSFVFVNLKPVTDGHVLVSPKRVVPRLTDLTDAETADLFIVAKKVQAMLEKHHNVTSTTICVQDGKDAGQTVPHVHIHILPRRAGDFGDNEIYQKLASHDKEPERKPRSNEQMAEEAVVYRNLM
What is the function of this protein?
Cleaves A-5'-PPP-5'A to yield AMP and ADP.
What are the official names of this protein?
Nitrilase and fragile histidine triad fusion protein NitFhit.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the UPF0012 family.
Protein: CH10_CLONN
Sequence: MRIKPLGDRVVIKRLEAEEKTKSGIVLPGSAKEKPQEAEIVAVGPGGLVDGKEVRMEVKVGDKVLFSKYSGTEVKLDGEEYTILRQNDILAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACY2_XENTR
Sequence: MTARRVLNPVQRVAIFGGTHGNELSGVFLVNHWLKHGEEIARPGIEVRPFITNPGAVEKCVRYVDTDLNRVFDSENLRNENNLNLSYEVKRAQYINSIFGPKGSEDAYDVILDLHNTTSHMGATLILEDSKDDFTIQMFNYIKTSMAPLACSVLLIEHPRLKYATTRSIAKHPIGVEVGPQPQGVLRADVLDKMRRIIKHALDFINYFNDGKEFLPCILEVFKVLDNVAYPRNANGDCTAIIHNNLQDQDWKELKPGDPMFLTLDGRMIAYEGDCIVYPTFINEAAYYEKNQAFTTTQKMTLCAQAIRCTEPK
What is the function of this protein?
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate.
What are the official names of this protein?
Aspartoacylase, Aminoacylase-2, ACY-2.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y1992_CHLCH
Sequence: MNPPNSTCELGRQGEALAATYLQNEGYQILERNYRFRHNEIDLIALDGSTLCFVEVKARLSNKAGSPLDAVTVAKQREIIRAAQAYLTFSGQECDCRFDVIGVNVHAMHEARISSFTIEHIKDAFWVEQ
What are the official names of this protein?
UPF0102 protein Cag_1992.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: VKT2K_HETCR
Sequence: GFYFRSIQGFYFKRIQGNICSEPKKVGRCRRSFPRFYFDSETGKCTPFIYGGCGGNGNNFETLHACRAICRA
What is the function of this protein?
Serine protease inhibitor that also shows protective effect in a cytotoxicity model.  It inhibits the serine protease trypsin (Ki=630 nM) (PubMed:35563513).  It significantly increases neuroblastoma cell viability in an in vitro neurotoxicity model, being a consequence of an effective decrease of reactive oxygen species (ROS) level in the cells (PubMed:35563513).  It also seems to protect cells by inhibiting ATP-induced purinoceptor (P2RX7) activation (PubMed:35563513).
What are the official names of this protein?
PI-stichotoxin-Hcr2k, PI-SHTX-Hcr2k, Kunitz-peptide HCIQ1c9.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: GATB_BURVG
Sequence: MTQWEVVIGLETHAQLSTVSKIFSGAPTQFGAEPNTQACPVDLALPGVLPVLNRGAVERAIRFGLAIGSTIAPRSIFARKNYFYPDLPKGYQISQYEIPVVQGGQITIQVPANEKAGKPAYEKTVNLTRAHLEEDAGKSLHEDFAGMTGIDLNRAGTPLLEIVTEPEMRSAAEAVAYAKALHALVVWLGICDGNMQEGSFRCDANVSVRPVGQEKFGTRAEIKNLNSFRFLEEAINYEVRRQIELIEDGGEVVQETRLYDPDKRETRSMRSKEDAHDYRYFPDPDLMPLVIGQDWIERVQAGMPELPAAIQQRFVDQYGVSAYDAGVLTSSKAMAAYFEAVVAKAGAANAKIAANWLMGDVSSQLNRDGIEIDAIPVSAAQLALVLQRIADGTISNKIAKEIFATIWDEKATDEGAADRIIDAKGLKQISDTGALEAIIDEVLAANAKSVEEFRAGKEKAFNALIGQAMKATKGKANPQQVNELLKKKLG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: DNLI1_DROME
Sequence: MQKSITSFFKKKSDATDSPSPPKKVPKIDAKTELPDEPHIKSESASPETKPKVEPMSVDSEEKTSPVKNVKKEPKEVDDKTTDKKVTTIGLNSTAATKEDVENYDPSADSYHPLKNAYWKDKKVTPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQLAPAYEGLELGVAETTLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMMFQPAPLNVRDVFRKLREIAKLSGQSKMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTALAIGLVKKNHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQERCPMHPGMPLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSENNTAKYPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIAKRSRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEYQSICKIGTGFTDEDLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQVWEVKCADLSLSPIHRAAIGIVDGERGISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSSTQMEMEDEFY
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase 1, DNA ligase I, DmDNA Lig I.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
Nucleus. Note=Does not accumulate at the replication foci (RF).
Protein: TBA5_MAIZE
Sequence: MREIISIHIGQAGIQVGNACWELYCLEHGIEHDGTMPSDSSVGVAHDAFNTFFSETGSGKHVPRAIFVDLEPTVIDEVRTGSYRQLFHPEQLISGKEDAANNFARGHYTVGKEIVDLCLDRVRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQIISSLTTSLRFDGAINVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVPEITNAVFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTVQFVDWCPTGFKCGINYQPPSVVPGGDLAKVQRAVCMISNNTAVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEGADDEGDEGDDY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-5 chain, Alpha-5-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y055_RICPU
Sequence: MFAIISSAKTLNFEKLAPKTELTIPMFLTLTNKLLSTLQSYSENQLSKIMNISAKLAHINKERFKDFDNQESKAAIFAYAGDVFNNIHIEKLTNHALNFLQSHLLIISGLYGVLKPLDTIKPYRLEMATKLNEINLTNFWQDEVTNYINKILAKQENKYLLNLASQEYSSVINPNKLKYQLVNVHFKENRNGKLSTIGINAKKARGAMVKVIANNLIDSPELLKNFSYLGYAFSTKHSSDNELVFIKS
What are the official names of this protein?
UPF0246 protein RPR_00055.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: DNAE2_VIBVU
Sequence: MFYAELFCQSNFSFLTGASHPEELIVQANFLGYHSLAITDECSLAGIVRAHSAIKQHQLSVKQIVGSFFKLNTECQFVLLCPNREAYAELCRIITNARRRCEKGQYQLSQWDVMSLKHCLLIWLPTGQTSDEQWATWLSRYQQSRLWLGLQRHLRHDDEHYLHHCQTLANQFDLPITACGGVLMHRPERLPLQHTLTAIRHGCTVEQLGTQLLTNAEQSLRSEKKLRKLFKPQWLAESLYIASLCSFDLDSLRYEYPSELIPDGYTPDSYLEHLVEQGKKLRFPEGVPDAIEQTIQKELALIKEQKYPFFFLTIHDIVMFAKQQGILYQGRGSAANSVVCYCLQITSVDPRQIAVLFERFISKERDEPPDIDVDFEHERREEVIQYIYQKYGRQRAALAATVISYRFKSAVRQVGKALGIEETQLDFFLKNINRRDRQAGWQAQLVELGLQPDSLKGQHFIQLVEEIIGFPRHLSQHVGGFVISSGPLYELVPVENAAMPERTIIQWDKDDLESLKLLKVDVLSLGMLTAIRKCFLSIEQHHQQRLSIADITRRQDDQAVYKMIQKADTIGVFQIESRAQMSMLPRLKPACYYDLVIQIAIVRPGPIQGDMVHPFLKRRDGEEPISYPSVHVQEVLERTLGVPIFQEQVIKLAMVAAGFSGGEADQLRRAMAAWKKNGHVFKFKTKLINGMLERGYELDFAERIFEQICGFGEYGFPESHSASFAVLAYCSAWLKHYYPAEFYTALLNSQPMGFYSPSQLVQDAKRHGIAVLPICVNFSNAEHQLVRLTSGELAIRLGFNLIKGLSHEGITRLLTHRPAQGYQCISEVKQILRQAKDIQSLASANAFYQLADNRYLARWQVMDNLDELPLFQTLPSISNNPLPKPSDYQNVLEDYAATGLSLAEHPVAMLEKAGGLTRFTRANQLNQCSHRSLVTVIGLVTGKQSPGTAAGVTFFTLEDDTGNINVVVWQATSRAQKQAYLTARLLMVKGILEREGDVIHVIAGRLIDLTEKLSGLSPKSREFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SBDS_RAT
Sequence: MSIFTPTNQIRLTNVAVVRMKRGGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKPNKSTKQQALEVIKQLKEKMKIERAHMRLRFLLPVNEGKKLKEKLKPLMKVVESEDYSQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLSLKDVEEGDEKFE
What is the function of this protein?
Required for the assembly of mature ribosomes and ribosome biogenesis.  Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.  Required for normal levels of protein synthesis.  May play a role in cellular stress resistance.  May play a role in cellular response to DNA damage.  May play a role in cell proliferation (By similarity).
What are the official names of this protein?
Ribosome maturation protein SBDS, Shwachman-Bodian-Diamond syndrome protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SDO1/SBDS family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus. Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (By similarity).
Protein: SEPF_STAA9
Sequence: MSHLALKDLFSGFFVIDDEEEVEVPDKQQQVNEAPAKEQSQQTTKQNAIKSVPQKSASRYTTTSEERNNRMSNYSKNNSRNVVTMNNATPNNASQESSKMCLFEPRVFSDTQDIADELKNRRATLVNLQRIDKVSAKRIIDFLSGTVYAIGGDIQRVGTDIFLCTPDNVEVAGSITDHIENMEHSFD
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: RAD51_BOVIN
Sequence: MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILTEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
What is the function of this protein?
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR).  Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.  Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template.  Recruited to resolve stalled replication forks during replication stress.  Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR.  Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.  Also involved in interstrand cross-link repair.
What are the official names of this protein?
DNA repair protein RAD51 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RAD51 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner. Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner. Colocalizes with ERCC5/XPG to nuclear foci in S phase. Recruited to stalled replication forks during replication stress by the TONSL-MMS22L complex, as well as ATAD5 and WDR48 in an ATR-dependent manner.
Protein: RS2_CLOB6
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIFTERNGIYIIDLQKTVKKVEEAYNFLRSVAEEGKDVLFVGTKKQAQEAIEEEAKRSEMHFVNNRWLGGMLTNFTTITARINKLEELDKMEEDGTFEVLPKKEVIKLKNEREKLEKNLGGIRKLDANNVGAMFIVDPRKEKNAILEAKRLGIPVVAIVDTNCDPDEVDFVIPGNDDAIRAVRLIAAKMADAVLEGRQGEQLAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PGLR_DIAAB
Sequence: IYTYVIGRG
What are the official names of this protein?
Endo-polygalacturonase, PG.
What are the subcellular locations of this protein?
Secreted.
Protein: IQEC1_MOUSE
Sequence: MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVGAYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARARDTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRSGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFQPPQPPVLCS
What is the function of this protein?
Guanine nucleotide exchange factor for ARF1 and ARF6.  Guanine nucleotide exchange factor activity is enhanced by lipid binding.  Accelerates GTP binding by ARFs of all three classes.  Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (By similarity).  Involved in neuronal development (PubMed:31607425).  In neurons, plays a role in the control of vesicle formation by endocytoc cargo.  Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity).
What are the official names of this protein?
IQ motif and SEC7 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the BRAG family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Postsynaptic density. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=At steady state, may be preferentially cytosolic.
Protein: RGI1_PICST
Sequence: MARAKKSKDSQPLDLNNCQPLEHLQPVPKTRSASIISVESTDSEGGVVEVLAPPQVREFDDLTAFEAFVRDETWDNDFDYFHGRLNYYPPFIMKECHDNLDKIKPTANKNSRKFKRNLQHHVARHLIKDLEKCCGYELHMDKFDTIETPNRITWKFKDESDHGFSKEEEDEYNRHWRLELSVSCNNENPMVEVDYKAIPI
What is the function of this protein?
Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
What are the official names of this protein?
Respiratory growth induced protein 1.
What is the protein family that this protein belongs to?
Belongs to the RGI1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HGPRT_STRP3
Sequence: MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKGSVPFMAELMKHIDTHVEIDFMVVSSYHGGTSSSGEVKILKDVDTNIEGRDIIIVEDIIDTGRTLKYLRDMFKYRKANTIKIATLFDKPEGRVVKIEADYVCYNIPNEFIVGFGLDYAENYRNLPYVGVLKEEVYSK
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
What are the official names of this protein?
Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_GEOUR
Sequence: MKTKFIFVTGGVVSSIGKGLAAASLGALLEARGLRVTHQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYTSARLSKKSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDEIKSKILDNAKGSDIAIIEIGGTVGDIESLPFLEAIRQFKADRGAGNVLYLHVTLVPFIKTADELKTKPTQHSVKELREIGIQPDILLCRCEQDLPREMKAKIALFCNVEEKAVITSMDAEHIYAVPLALHKEGLDEQVVEKLNIWAKAPDLTPWQQVVDKLMHPGHGKVRIAIVGKYVNLTESYKSLAEALTHGGIANDCRVHLSYLDSEKIEQEGIDGLLDGVDGILVPGGFGERGTEGKIKAIEYARTRKIPFFGICLGMQMAVVEYARNVCHLDDAFSSEFKQDCANPIIHLMEEQKGVSRKGGTMRLGAYPCTLAKGSFAQKAYGTLDISERHRHRYEFNNDYRDLLVSNGLILSGIYKEGDLVEIVEIPDHPWFVGCQFHPEFKSKPLNPHPLFRAFIAAALHNIKA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: TERM_BP35C
Sequence: MANKRLKKKLETKRKKSLLVSEGYSKKETKKLKGRELETVYKKKAHNRKNRERAREIANLAKQWGLSPSKYNSWKKLLPEIERIKKEQDREAPFLLIYYQDFTGETDSKFIYDFKKRNNTRSRSQITESIIGWLQNAHNKLFLGRVAIRIVPKRDVSKTNTLWRNHGYVKIYEGQGKELSKLLTAIETIMVGVYDVKERDKYLKELVAKLRSLPYEKAKKNAKEIQKIYDTKSYKKESWDNDDYY
What is the function of this protein?
Acts as a primer for viral genomic replication.  DNA terminal protein is covalently linked to the 5'-ends of both strands of the genome through a phosphodiester bond between the beta-hydroxyl group of a tyrosine residue and the 5'-phosphate of the terminal deoxythymidylate.  This protein is essential for DNA replication and is involved in the priming of DNA elongation.
What are the official names of this protein?
DNA terminal protein.
What are the subcellular locations of this protein?
Virion.
Protein: DCUP_SALPA
Sequence: MTELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRYPLDAAILFSDILTIPDAMGLGLYFEAGEGPRFTAPVTCKADVDKLPIPDPEDELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTVIKKMMYADPQALHLLLDKLAKSVTLYLNAQIKAGAQSVMIFDTWGGVLTGRDYQQFSLYYMHKIVDGLLRENDGRRVPVTLFTKGGGQWLEAMAETGCDALGLDWTTDIADARRRVGHKVALQGNMDPSMLYAPPARIEDEVATILAGFGQGEGHVFNLGHGIHQDVPPEHAGAFVEAVHRLSAQYHS
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPT_PROMM
Sequence: MSRRSATSSGHPKVCACPSGLDPYRLPNHVAVIMDGNGRWAKARGLPRMVGHRAGVEALKRTLRLCSDWGIGALTAYAFSTENWSRPGDEVNFLMTLFERVLQRELESLEREKVRIRFLGDLEGLPSGLQELISEATELTVRNNGIHFNVCTNYGGRRELVLAAQKLAQRAARGDLDPTLIDENSFEAELLTAGEVDPDLLIRTSGERRISNFLLWQLAYAEIHVTDVCWPDFDEVALTKALFDYQSRCRRFGGLDPIAANHLGS
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: KHSE_BURP6
Sequence: MAVFTAVSDADLALWMRHYDLGDVVAFRGIPSGIENSNFFLTTTRGEYVLTIFENLTAGQLPFYVHLMSHLAKHGVPVPAPVARDDGTLFGELHGKPAAIVTKLEGAAQLAPGVEHCVEVGQMLARMHLAGRDYPRHQPNLRSLPWWRDTVPAIAPFVTGEQRALLEGELAHQAAFFASDDYAALPEGPCHCDLFRDNALFAHAEPDTGHSVRLGGFFDFYFAGCDKWLFDVAVTVNDWCVDLPTGALDAARADALLRAYQTVRPFTAGERRHWGDMLRAGAYRFWVSRLYDFHLPRAAQMLKPHDPGHFERILRERIAHAGAPPETHACN
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: YM099_YEAST
Sequence: MNSENSKITFKPNILIKGVYIFVLYGMCICIVKNYFKTQLFQLLAPAIHEKSKNNIFMIASDSFPNLYKQNTNYRPAHPLSVASKLPTLLAWLPNRSPLHFQLIWLPIF
What are the official names of this protein?
Putative uncharacterized protein YML099W-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IHFB_RHIEC
Sequence: MIKSELVQIVAARNPHLYHRDVENIVNAVLDEITDALAAGNRVELRGFGAFSVKNRPSRSGRNPRTGDTVFVEEKWVPFFKTGKELRERLNPGQADEED
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.