PharMolix/UniProtQA huggingface dataset:
Protein: KAZRN_HUMAN
Sequence: MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEEQMDRLQQVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLSLSDEDLQLGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMSAVFHPANSTGIREAERFGTPPGRASSVTRAGKEENSSGLKYKAGRLPLGKIGRGFSSKDPDFHDDYGSLQNEDCGDDDPQSRLEQCRLEGYNSLEVTNV
What is the function of this protein?
Component of the cornified envelope of keratinocytes.  May be involved in the interplay between adherens junctions and desmosomes.  The function in the nucleus is not known.
What are the official names of this protein?
Kazrin.
What is the protein family that this protein belongs to?
Belongs to the kazrin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.
Protein: DLGP2_HUMAN
Sequence: MGTAQVLPGILQKHCCILPDRNTESQCTLCGEPEEEEAGDLVQPGISFPGPAEEDLDPQYSWSPTQHFNEERYSPAPRSMKGLSGSRTQPPLCSGHTCGLAPPEDCEHLHHGPDARPPYLLSPADSCPGGRHRCSPRSSVHSECVMMPVVLGDHVSSSTFPRMHYSSHYDTRDDCAVAHAGAKINRIPANLLDQFEKQLPLHRDGFHTLQYQRTSAAAEQRSESPGRIRHLVHSVQKLFTKSHSLEGSSKSNANGTKADGRADDHHHAHHAKHSKRSKSKERKPEGKPRPGMSSWWSSDDNLDSDSTYRTPSVLNRHHLGPVAHCYPDALQSPFGDLSLKTSKSNNDVKCSACEGLALTPDAKYLKRSSWSTLTVSQAKEAYRKSSLNLDKPLLHQDAKPALRPCHYLQVPQDEWGGYPTGGKDEEIPCRRMRSGSYIKAMGDEESGESDSSPKTSPKSAILPEPLLKSIGQRPLGEHQTQTYLQAASDVPVGHSLDPAANYNSPKFRSRNQSYMRAVSTLSQASCVSQVSEAEINGQFESVCESVFSEVESQAMDALDLPGCFRTRSHSYLRAIQAGYSQDDECIPMMTPSDITSTIRSTAAVSYTNYKKTPPPVPPRTTSKPLISVTAQSSTESTQDAYQDSRAQRMSPWPQDSRGLYNSTDSLDSNKAMNLALETAAAQRHLPESQSSSVRTSDKAILVSKAEELLKSRCSSIGIQDSEFPEHQPYPRSDVETATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQADLELEGFPGHITTEDKGLQFGSSFQRHSEPSTPTQYSAVRTVRTQGLFSYREDYRTQVDTSTLPPPDPWLEPAIDTVETGRMSPCRRDGSWFLKLLHAETKRMEGWCKEMEREAEENDLSEEILGKIRSAVGSAQLLMSQKFQQFYWLCQQNMDPSAMPRPTSQDLAGYWDMLQLSIEDVSMKFDELQRLRLNDWKMMESPERKEERKVPPPIPKKPPKGKFPITREKSLDLPDRQRQEARRRLMAAKRAASFRQNSASERADSIEIYIPEAQTRL
What is the function of this protein?
May play a role in the molecular organization of synapses and neuronal cell signaling.  Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton.  May induce enrichment of PSD-95/SAP90 at the plasma membrane.
What are the official names of this protein?
Disks large-associated protein 2, DAP-2, PSD-95/SAP90-binding protein 2, SAP90/PSD-95-associated protein 2, SAPAP2.
What is the protein family that this protein belongs to?
Belongs to the SAPAP family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Postsynaptic density. Synapse. Note=Postsynaptic density of neuronal cells.
Protein: RS7_SALSA
Sequence: NWSSLIFSLNLQRRILPKPTRKSRIKNKQKRPRSRTLTAVHDAI
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Required for rRNA maturation.
What are the official names of this protein?
40S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS7 family.
Protein: DNAJ_LEPIN
Sequence: MSERSYYDILGVSKSANDEEIKSAYRKLAIKYHPDKNKGNKESEEKFKEATEAYEILRDPKKRQAYDQFGKAGVSGGAGGFGQGAYTDFSDIFGDFGDIFGDFFGGGRSSGFGGGRRSGPQRGSDLRYNLEVSLEDAALGREYKIEIPRLESCVDCNGSGASKGSSPATCPDCGGSGQIRRTQGFFSVATTCPTCRGKGTIISNPCRSCGGQGLQEKRRTINIKIPPGVETGSRLKVSGEGEAGPNGGPHGDLYVVTHIKKHELFERQGNDLILVRKISLAQAILGAEIEVPTIDGKKAKMKIPEGTESGQVFRLKGHGMPYLGAYGKGDQHVIVKIEIPKKITRRQRELIEEFARESGENIPGSKGKIFTK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIDJ_LEGPH
Sequence: MFGFIKKVLDFFGVDQSEDNPSETAVETTDVSTKIKTTDTTQEESSVKTKTVVPTQPGGSVKPETIAPDQQKKHQIKTETTTSTTKQKGPKVTLMDGHVKQYYFARRGETSTHDTSLPPPVKVLSGRSIPLKEIPFEATRNELVQIYLTSIDKLIKSNKLNSIPSQQIASHYLFLRSLANSETDGIKKNQILSLAKPLGTYLASKEPHVWKMINELIEKSEYPIIHYLKNNRAHSNFMLALIHEYHKEPLTKNQSAFVQKFRDSSVFLFPNPIYTAWLAHSYDEDSSFNPMFRERLSTNFYHSTLTDNLLLRTEPKEVTLSSEHHYKKEKGPIDSSFRYQMSSDRLLRIQGRTLLFSTPQNDVVAVKVQKKGEPKSTLEEEFEMADYLLKHQRRLDVHSKLPQPLGQYSVKKSEILEISRGSLDFERFKTLIDDSKDLEVYVYKAPQSYFTYLHDKNQDLEDLTASVKTNVHDLFVLLREGIVFPQLADIFHTHFGEDEREDKGRYQALVQLLNVLQFQLGRIDKWQKAVEYVNLRSSGLADLGDSLPITSLFTSSDFTKHYFSELLTGGYHPTFFDKSSGTANSLFTGKRRLFGNYLYLNTIAEYLLVIQLTLGSYGDKVTRDMMDKPKKEAVWRELANVMFTSCAEAIHIMTGIPQSRALTLLKQRANIEKHFRQTQFWMTPDYSKLDEDTLQMEQYSIYSGEPEYEFTDKLVSGVGLSVDGVHQDLGGYNRESPLRELEKLLYATVTLIEGTMQLDKEFFKQLEQVEKILSGEIKTDANSCFEAVAQLLDLARPGCHFQKRLVLSYYEEAKLKYPSAPTDAYDSRFQVVARTNAAITIQRFWREARKNLSEKSDIDSEKPESERTTDKRL
What is the function of this protein?
Glutamylase that mediates the covalent attachment of glutamate moieties to SdeA on one of the catalytic residues that is required for its mono-ADP-ribosyltransferase activity (PubMed:31330532, PubMed:31330531).  In turn, inhibits SdeA ubiquitinating activity.  Glutamylates also related SdeB, SdeC and SidE (PubMed:31330531, PubMed:31123136).  Glutamylase activity only occurs in the host since it requires host calmodulin (PubMed:28497808, PubMed:31330532, PubMed:31330531, PubMed:31123136).  May also reverse the SdeA-mediated substrate ubiquitination by cleaving the phosphodiester bond that links phosphoribosylated ubiquitin to protein substrates via its deubiquitinase activity (PubMed:28497808).
What are the official names of this protein?
Calmodulin-dependent glutamylase SidJ.
Protein: B4GT7_HUMAN
Sequence: MFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPPPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS
What is the function of this protein?
Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.
What are the official names of this protein?
Beta-1,4-galactosyltransferase 7, Beta-1,4-GalTase 7, Beta4Gal-T7, b4Gal-T7, Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7, UDP-galactose:beta-xylose beta-1,4-galactosyltransferase, XGPT, XGalT-1, Xylosylprotein 4-beta-galactosyltransferase, Xylosylprotein beta-1,4-galactosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 7 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Note=Cis cisternae of Golgi stack.
Protein: SODF_RICTY
Sequence: MTYCRKANQTSYPFILPDLPYAKESFKPHFTCETFDYHHGKHHNSYVQNLNNLLKDREELQKKDLEGIIKWSSKNSEVTVFNNASQIWNHTFFWYSIKPHGGGKPSGKVFEQISQDFGSFEQFCEQFKQEALGQFGSGWVWVVYNNNKLQIIKTSNADTPIVNLMKPILVCDVWEHAYYIDYRNKRSDYIDIFISHMINWKFVEDNLIQ
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.
What are the official names of this protein?
Superoxide dismutase [Mn/Fe].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: TAP2_SOYBN
Sequence: MLTFNLNAISSSFSVVPFHANYPLSTQTQLLVPSNLSYSFATTGTRKFKSFQLKAGFWESIKSGLMKNNSMQVIDPPSADEEDEEPLPQEFVLVEKTEPDGTIEQIIFSSGGDVDVYDLQALCDKGWPRRPLSKLAAALKNSYIVASLHSIRKSPGSEGNEQKRLIGMARATSDHAFNATIWDVLVDPGYQGQGLGKALIEKLIRTLLQRDIGNITLFADSQVVEFYRNLGFEADPEGIKGMFWYPNH
What is the function of this protein?
May acetylate histones H2A and H3.
What are the official names of this protein?
Probable acetyltransferase TAP2, GmTAP2.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COBD_HALH5
Sequence: MIACHVIAIVSAFILDKWLGDPKWLPHPVVGMGKLITYFERRWNCGRWRREKGVLLLLTVLLIVTALSLALVWLSYQVHLLLGVIVEALLIASTIAAKGLKEAAEEVARPLATRNLLEARRKLSYIVGRDTDQLDEKEIARGAIETVAENTSDGVTAPLFYALIGGAPLALLYRATNTCDSMVGYKNERYRDFGWASAKFDDVLNWVPSRITGVLMLLLHRKRRQAPLGQSLKMLAREAKKHPSPNSGWGEAAMALLLHVTLGGTNTYQGMTSERAKMGYGTKAMTAKDIDESIAIMNRTVLGFLVFLFLLGGFIYAIT
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
Protein: HSCA_SHESH
Sequence: MALLQIAEPGQTAAPHQHRLAVGIDLGTTNSLVAAVRSGVADTLPDENARHSLPSIVRYTDTGIEAGFEAEAHSAKDPQNTIVSVKRFMGRSLADIQSGIQDLPYRFQASENGLPLFATEQGTVNPVQISSEILKPLISRAESTLGGDLEGIVITVPAYFDDAQRQGTKDAAALLGVKVLRLLNEPTAAAIAYGLDSGQEGVIAIYDLGGGTFDISILRLNKGVFEVLATGGDSALGGDDFDHLLHHHLLQEWQIDAPSASVSRQLLIESRRVKEVLTDESEVTATLLLDDGTTLTHVVTKSLFDSLITSLVKKTVASCRRALRDAGIKADEVLETVLVGGSTRVPLVRELVEGFFGKAPLTSIDPDRVVAIGAAIQADILVGNKPESDLLLLDVLPLSLGIETMGGLVEKVVSRNTTIPVAKAQEFTTFKDGQTAMAFHVVQGERELVDDCRSLARFTLKGIPPLAAGAAHIRVTFQVDADGLLSVTAMEKSTGVQSSIQVKPSFGLTDEEIGSMLKDSMANAKDDIARRMLAEQQVEAARVLETLSAALAKDGELLTADERNAIEQSMAVLVEVGGQDDADAIEKAIEALDASTQDFAAKRMDNSIKLALKGQSVDSI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MRAZ_THET2
Sequence: MPFGEYQYSLDDKGRVVIPAPFRDFVEDGLVLTRGMEGCLYVFPLDRWKKIEEQLVNLPLTDAEARAFVRFFYSGAHKTRMDSASRVLIPPPLRLFAGLKEGGEVVIAGAPGRLEIWSQERWWKAIEEVLAKPPAPEALKGLVG
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: IDI2_BACC3
Sequence: MVRAKRKLDHIEYALSTGQSRTHGFHDIDFVHQSLPNSSYETITCETKIGELSLSSPIFINAMTGGGGEKTLHINEQLAYVAKHHNLAMAVGSQMAALKDESEAASYKIIRKVNPNGIFFANLGSEATVEQAELAVDMIEANALQIHLNVIQELTMPEGDRDFTGVLQRIEKIVLNSKVPVIVKEVGFGMSKETMQQLASVGVTAIDIGGQGGTNFAAVENERRQRMLSYFNNWGIQTATSIIEATSTNNNLSFIASGGIQTALDVAKAIALGANTTAFAGYFLRILMEDGIEKLVDEIDLLHTDLKFIMTALGAKTIEELQSVPLVVKGETYHWLTQRGIDTTHYSRR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_MOOTA
Sequence: MAHMRDLKRRIRSVQSTQHITRAMKMVAAAKLRKAQAQVTAARPYAAKLEEVVGRLMAAVDPETQPLAATREVKKAGYVLITADRGLAGGYNANLIRLTEERLREEGRPAALVAVGRKGRDFFRRRPVEIVKSFTDIGDNPELIQARELARQLVTMYLEGTLDEVNLIYTRFYSAIRQVPMVERLLPIATPREKKDTGDYIYEPSPEAVLRVLLPRYCEIKVYRALLEAKASEHGARMTAMDNATKNAAEMIDKFTLSFNRARQAAITNEIVEIVAGADALK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL9_RICTY
Sequence: MEIILIKPVRKLGKIGDILKVANGFGRNYLLPQKLAIRATKSNKELIVKQKHEFEAKDKQIRAEVEKINTLIKDQQLVFIRQTSDDCKLFGSVTNKDIADKLSKNISYNISHSNVILDKQIKSTGIYTVEIRLHAELTAIVTVIVARSDSEAQDYLREQKTENSADLAESE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: PDXT_MYCS2
Sequence: MTAHVGVLALQGDTREHLAALREAGAEASTVRRLSELAAVDALVIPGGESTAISHLLREFDLLEPLRARIAEGMPCYGSCAGMILLATEIADAGVPGRAAVPLKGIDMTVRRNAFGRQVDSFEGDIDFVGLDTPVHAVFIRAPWVERIGPDVEVLARADDHIVAVRQGPMFATAFHPEVTGDRRIHKLFVDSL
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: NUOB1_CHLAA
Sequence: MAEIDPTQLELERQGILLTTVNRFYNWGRRSSIWPMAFGLACCAIEMMAFGLSRYDVARFGAELFRASPRQADLMIVAGTVTKKMAPQVVRLYNQMAEPRYVISMGACATSGGPFRDGYNVLRGIDLLIPVDVYVPGCPPRPEALLHALMTLQEQIDRQKLGRVRWYGSGDKPQTGDFPVPTFGAKGLEIDGKLVDPVGGLPLLSPYTSPSHGEHRSGQIEHPEVVRQFPIMDPEVELENALKARGIAPEIAADDLKRSVVNDA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 1, NADH dehydrogenase I subunit B 1, NDH-1 subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SRARP_HUMAN
Sequence: MAPSEDPRDWRANLKGTIRETGLETSSGGKLAGHQKTVPTAHLTFVIDCTHGKQLSLAATASPPQAPSPNRGLVTPPMKTYIVFCGENWPHLTRVTPMGGGCLAQARATLPLCRGSVASASFPVSPLCPQEVPEAKGKPVKAAPVRSSTWGTVKDSLKALSSCVCGQAD
What is the function of this protein?
May regulate the transcriptional function of androgen and estrogen receptors.
What are the official names of this protein?
Steroid receptor-associated and regulated protein, Estrogen receptor-related factor, ER-related factor, Steroid receptor-regulated protein.
Protein: ISPG_ACIBY
Sequence: MIENPIKRRPTRKIRVGSVYVGGDAPISVQSMTNTETCDVDATVAQIERCVDAGADIMRVSVPSMEAAEAFGAIRKRVSVPLVADIHFDHRIALAVADYGADCLRINPGNIGSDQKVREVVAAARHHGISMRIGVNAGSLEKDLQKKYGEPTGQALLESALRHIDILDRLDFHEFKVSVKASNVFLTMDAYRLLSQQIDNPLHLGVTEAGIYRTGTVKSAIALGGLLMEGIGDTMRISLAAEPEDEIKIGFDILKSLGLRSNGINFIACPSCSRQEFNVIQVMQALEERLEDIRTPMDVSVIGCKVNGPGEAKEADIGVVGAAPRSLVYRNGEKSHLIDTNQLVDEIETMVRQRVQELEEAKSKEIIRSSS
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: PIWL1_DANRE
Sequence: MTGRARARSRGRGRGQEPAAPGAQPPVSQEAAKPVVSTPSEGQLVGRGRQKPAPGAMSEEAMLQISAGFQQVKIGERGGRRRDFHDSGVHTRQLMEHVKESKTGVSGTAIELRANFMRLLSRPMWALYQYHVDYKPPMESRRLRSALLFQHEETLGKAHTFDGAILFLPNKLRNAETVLCSETRNGEKVEITVTLTNELPPSSPVCLQFYNILFRRILRILNMQQIGRHYYNPDDPFNIPQHRLTIWPGFMTTILQYESSIMLCSDVSHKVLRSETVLDFMYSLRQQCGDQRFPEACTKELVGLIILTKYNNKTYRIDDIAWDHTPNNTFKKGDTEISFKNYFKSQYGLDITDGNQVLLVSHVKRLGPSGRPPPGPAMLVPEFCYLTGLTDKMRADFNIMKDLASHTRLSPEQREGRINRLISNINRNGDVQNELTTWGLSFENKLLSLNGRVLPSERIIQGGRAFEYNPWTADWSKEMRGLPLISCMSLDNWLMFYTRRNADVAQSLLQTLNKVSGPMGIRMQRAVMIEYEDRQESLLRALQQNVARETQMVVVILPTNRKDKYDCVKKYLCVDCPTPSQCVVSRTISKPQALMTVATKIALQMNCKMGGELWSVEIPLRQLMIVGIDCYHDTAAGKRSIGAMVASLNQGMSRWFSKCVLQNRGQEIIDALKGSLQGALKAYLKYNNSLPSRIIVYRDGVGDGMLQSVVDYEVPQIMQSIKTMGQDYEPKLSVVVVKKRISSRFFARIDGKIANPPPGTVIDTEVTRPEWYDFFIVSQAVRFGCVAPTHYNVVFDNSGLKPDHMQRLTYKLCHMYYNWQGIVRVPAPCQYAHKLAFLVGQSIHKEPNMNLDDFLYYL
What is the function of this protein?
Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:14516689, PubMed:17418787, PubMed:18833190).  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:14516689, PubMed:17418787, PubMed:18833190).  Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:14516689, PubMed:17418787, PubMed:18833190).  Has a strong preference for piRNAs with a uridine nucleotide at their 5'-end (g1U preference, also named 1U-bias) and binds piRNAs in an opposite direction compared to piwil2/zili (PubMed:14516689, PubMed:17418787, PubMed:18833190).  Participates in a piRNA amplification loop with piwil2/zili (PubMed:14516689, PubMed:17418787, PubMed:18833190).  Not involved in the piRNA amplification loop, also named ping-pong amplification cycle.  Acts as an endoribonuclease that cleaves transposon messenger RNAs (By similarity).
What are the official names of this protein?
Piwi-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Piwi subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis.
Protein: GEMI7_SCHPO
Sequence: MAENNKKSTAYIQRMRTLKFYQKMASARIPITVYLHDQREVKAEFGAIDSSESKLAVSNLQTDWGVINRAVIRTGDVVGIEYNLVQEEGEL
What are the official names of this protein?
Gem-associated protein 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the gemin-7 family.
Protein: EFP_STRGG
Sequence: MASTNDLKNGLVLKLDGGQLWSVVEFQHVKPGKGPAFVRTKLKNVLSGKVVDKTFNAGVKVDTATIDRRDMQFSYMDGEYFVFMDMDTYDQLMVDRKAVGDAANFLIEGFTASVAQHEGEVLYVELPAAVELTIQHTDPGVQGDRSTGGTKPATLETGYEIGVPLFITTGEKIKVDTRSGDYLGRVNS
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KATG_RALPJ
Sequence: MTTEAKCPFSGHAPAASHAFGGGTANKDWWPNQLRVDLLNQHSEKSDPLGSNFNYRKSFNAIDYDALKADLRRLMTDSQDWWPADFGHYGPQFIRMAWHAAGTYRTGDGRGGAGRGQQRFAPLNSWPDNVNIDKSRRLLWPIKQKYGQAISWADLLILTGNVALETMGFRTFGFAAGREDTWEPDNDVYWGNETKWLEATRYSGERNLANPLAAVQMGLIYVNPEGPEHAHGDPLAAAKDIRETFARMAMDDEETVALIAGGHTFGKTHGAGPASHVGADVEAAPLEAQGLGWASTFGTGKGADAITSGLEVTWTQTPAQWSNFFFENLFKYEWVQEKSPAGALQWVAKDAEAIIPGPTPDSPKRRPTMLTTDLSLRFDPAYEKISRRFLDNPQAFAEAFARAWFKLTHRDLGPKSRYLGPEVPREDLIWQDPLPTATHKPTEADIADLKAKIAASGLSASELVAVAWASASTFRGSDKRGGANGARIRLAPQKDWAVNQPVAGTLARLEEIQRASGKASLADVIVLAGSVGIELAAKAAGTTITVPFTPGRVDATAEQTDATSFSVLEPVADGFRNYQKTQFAVPGEVLLLDRAQLLTLTAPELTVLIGGLRAININADGSQHGVFTSTPGALTNDFFVNLLDMNTEWKPAGDIYEGYDRKTGERKWTGTRVDLVFGSNSILRALAEVFGSADGKERFISEFVAAWVKVMNLDRFDLAAA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: UVRB_SYNJB
Sequence: MSEFQLVSPYQPTGDQPKAIAGLVKSISEGHRFQTLLGATGTGKTFTIAHTIQQVGRPTLVMAHNKTLAAQLCNELRELFPHNAVEYFISYYDYYQPEAYVPSTDTYIAKSSSINDEIDMLRHSATRSLFERRDVIVVASVSCIYGLGMPEEYLKASIPFKVGQEINQRDVLRDLASIQYERNDLELVRGRFRLKGDVLEIVPAYEDRVIRIEFFGDEIEAIRLIDPVTGEILNSLSALRVYPARHFVTPEAQLERAILNIEQELEEQLALFRKEGKLLEAQRLEQRTRYDLEMLREVGYCNGIENYSRHLTGRKAGEPPACLVDYFKADDWLLVVDESHVTVPQIRGMYNGDRARKQVLVDHGFRLPSALDNRPLKAEEFWAKVHQCIFVSATPGNWELEQSEAQFETRVEDGKTLKFYVQGSGRVIEQVIRPTGVVDPEVHVRPTAGQVDDLLGEIYLRLERSQLGPAERVIVTTLTKRMAEDLTEYLQERGIRVRYLHSEITSIERIEILQDFREGAFDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQMIGRAARNVRGMVVMYADTMTSSMARAIAETQRRREIQLQYNRQHNITPKPIVKKNSNAILSFLAISRKLNDPDLEKAFQAAQEIPLSEIPELIGQLELKMKEAAKNLEFEEAAQLRDRIKKLRQRLLGHPQGI
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.