PharMolix/UniProtQA huggingface dataset:
Protein: DER_LISMO
Sequence: MAKPVVAIVGRPNVGKSTIFNRIVGERVSIVEDVPGVTRDRIYNSAEWLGKEFNIIDTGGIDLSDEPFLEQIRAQAEIAIDEADVIIFITNGREGVTDADEQVAKILYRSNKPIVLAINKVDNPEMRDQIYDFYSLGFGEPYPISGSHGLGLGDMLDAVRAHFPKEEEEEYPDDTVKFSLIGRPNVGKSSILNALLGEDRVIVSDIAGTTRDAIDTTYTFDGQDYVMIDTAGMRKRGKVYESTEKYSVLRAMRAIERSDVVLVVINAEEGIREQDKRIAGYAHDAGRAIIIVVNKWDAINKDEKTINVWTEDIREQFQFLSYAPIVFVSAKTKQRLNNLFPLINQVSDNHSLRVQSSMLNDVISDAVAMNPSPMDKGKRLKIFYTTQVAVKPPTFVVFVNDPELMHFSYERFLENRIREAFPFEGTPIRVIARKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: TMCO4_MOUSE
Sequence: MATWNRPHPRQPVAPEPAAEDDSQQPLGRELSEANRFAYAALCGFSLSQLFPEPEQSSFCTEFVTGLVKWLHLSESVLPTIMAFASGLGGEGADIFAQTLLQDPILRDNPSAVSQDLLSFSLKNGHYDARARVLVCHVTSLLQVPMEELDILEEVFLESLKDAKEEESETAEASRKRKEKRRKWKRYLLIGLATVGGGTVIGVTGGLAAPLVAAGAATIIGSAGAAALGSVAGIAVMTSLFGAAGAGLTGYKMKKRVGAIEEFMFLPLTEGRQLHITIAITGWLGSGRYRTFNAPWMALARSQEQYCLAWEAKYLMELGNALETILSGLANMVAQEALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEQDCQGIIEDVVLLGAPVEGDPKHWEPFRNVVSGRIINGYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDRRMENVDLTSVVNGHLDYAKQMDAILKVVGIRTKPGWREKGLPLAPGSLPQEEPLQTAIVSTDEIILQDGQSQGPASEDSLKTTIPSSASQAQMPAGLNQSTEDSLSTAAAPAEGHLICSHGVGPNPLGCPDCTHGTQESCTELD
What are the official names of this protein?
Transmembrane and coiled-coil domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the TMCO4 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYDND_PSEPW
Sequence: MMRSHYCGQLNESLDGQEVTLCGWVHRRRDHGGVIFLDIRDREGMAQVVFDPDRAETFAAADRVRSEYVVQITGKVRKRPDGAVNANMASGAIEILGYQLNVLNEAETPPFPLNEYSDVGEETRLRYRFIDLRRPEMADKLRLRSRITSSIRRFLDENGFLDVETPILTRATPEGARDYLVPSRTHAGSFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQPEFTQIDIETSFLDESEIMGLTESMIRKLFKEVLDLEFGEFPHMTFEEAMRRYGSDKPDLRNPLELVDVADQLKDVDFKVFAGPANDPKCRVTALRLPGGASMPRSKIDEYTKFVGIYGARGLAYIKVNERAKGVEGLQSPIVKNIPEANLNVILDRVGAVDGDIVFFGADKFKVVSEALGALRIRLGHDFELLTCEWAPMWVVDFPMFEENEDGSFTALHHPFTAPKCTPEELEANPATALSRAYDMVLNGTELGGGSIRIHRKEMQQAVFRLLGIEAAEQEEKFGFLLDALKFGAPPHGGLAFGLDRLVMLMTGAQSIREVIAFPKTQSAACVMTQAPGLVDAKALRELHIRLREQTKVE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_STREM
Sequence: MSGKIGLYTGSFDPVTNGHMDMIKRASHLFEHVYVGIFNNPNKQSFFTFELRAQMLREAVCALPNVTVVSAEHGLAVDLARELSVTHLIRGLRNTADFDYEAGLEYFNHRLAPDIETIYLMANHDLQPISSSRIRELIAFRAPITGLVPQAVINQVEKMNENNKKI
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSTM5_MESAU
Sequence: SMVLGYWDIRRMLLEFTDTSYEEKRYICGEAPDYDRSQWLDVKFKLDLDFPNLPYLMDGKNKITQSNAILRIRVDIMENQIMDFRQFSLFLGKKLTFVDFLTYDVLDQNRMFEPKCLDEFPNLKAFMCRCFKMPINNK
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase Mu 5, GST class-mu 5.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Mu family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_XANC5
Sequence: MRTHFCGLVDETLIGQTVTLAGWTDVARNLGGVCFIDLRDHEGIVQVTVEPVAGDDASAELFKVAASLGYEDVLQVEGVVRARHAVNDKLRSGKVEVIATRISILNKAAPLPFHAHENPGEETRLKYRYLDLRRPEMQRMQRTRIKLVQALRRHLDARDFQDIETPILTKATPEGARDFLVPARMHPGEFYALPQSPQLFKQILMVAGFDRYYQIARCFRDEALRADRQLEFTQLDMEFAFVRERDVQDFVEDMIRAIFKEVVDVDLAAQFPRMTWAEAMRRYGSDKPDLRIALELVDVAELVKASQFPVFTAAADDADGRVAALLIPGGASLSRKQIDEYAAHAAKYGAKGLAYIKLSETGEVSSPIAKFFSEESFAALLKHVGASNGDIVFFGAGGYTKVSDFMGALRLKAGKDFNLVADGWAPLWVTDFPMFEWDDEAQRYVALHHPFTAPAVDDIADLRANARTAVSRGYDMVLNGNEIGGGSIRIHRPDMQSAVFELLGIGAEEARAKFGFLLDALNYGAPPHGGIAFGIDRIAALMAGTESIRDVIPFPKTTGAQDLMTDAPSPIAADQLAEVHVQVRPKQV
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C78A6_ARATH
Sequence: MATKLESSLIFALLSKCSVLSQTNLAFSLLAVTIIWLAISLFLWTYPGGPAWGKYLFGRLISGSYKTGNVIPGPKGFPLVGSMSLMSSTLAHRRIADAAEKFGAKRLMAFSLGETRVIVTCNPDVAKEILNSPVFADRPVKESAYSLMFNRAIGFAPHGVYWRTLRRIASNHLFSTKQIRRAETQRRVISSQMVEFLEKQSSNEPCFVRELLKTASLNNMMCSVFGQEYELEKNHVELREMVEEGYDLLGTLNWTDHLPWLSEFDPQRLRSRCSTLVPKVNRFVSRIISEHRNQTGDLPRDFVDVLLSLHGSDKLSDPDIIAVLWEMIFRGTDTVAVLIEWILARMVLHPDMQSTVQNELDQVVGKSRALDESDLASLPYLTAVVKEVLRLHPPGPLLSWARLAITDTIVDGRLVPAGTTAMVNMWAVSHDPHVWVDPLEFKPERFVAKEGEVEFSVLGSDLRLAPFGSGRRICPGKNLGFTTVMFWTAMMLHEFEWGPSDGNGVDLSEKLRLSCEMANPLPAKLRRRRS
What is the function of this protein?
Plays role in seed and fruit development.  Functions probably in association with CYP78A9 in the regulation of seed growth.  Acts maternally to promote seed growth.
What are the official names of this protein?
Cytochrome P450 78A6, Protein ENHANCER OF DA1-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CAS2B_ARCFU
Sequence: MVVIVYVIVAYDVNVERVNRVKKFLRRYLNWVQNSLFEGELSSADLEEVKMGLREIINEDEDMVVIYRFRSADAFKREVMGIEKGLGGEEVI
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2 2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: COQ4_COPC7
Sequence: MLGRRSVSLLRGLTELPVSSRAHTALRALSVPQTRRNVATKPNYEGHIPLNWFENALLTAGAAYMSITDPRRGDMVAALGETTAGPTVSWLRDQMLASPEGRQILKDRPRITSSTVDMDKLAQMPEGTFGRAYINWLERCGVTPDTREPVHYIDDPELAYVMQRYRECHDFYHCICNMPVNVESELAVKYFEFANLGLPMAGLAALFGPLRLNAQKRNWLFTEAVPWALKCGSSARSLITVYWEKRWEEQVEDMKKEFGIWDGPEARWSKPLNEAKEAAERRSKTTQNQIY
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: PEX6_CRIGR
Sequence: MALAVLRVLDPFPAETPPLAVLLPPGGPWPATGLGLVLALRPASESPAGPALLVAALEGPGSQNGQRGPGPPQLLVSRALLRLLALGPGARVRARPVRRPPALGWALLGSAPGPGPGPRVGPLLVRRGESLPVPGSRVLETRPALQGLLGPGTRLAVTELRGRAKLGPESTQHSRLPPPPVASSFAVSHAVRQLKGVLGGTGDALGVTRSCLRGLGLFQGEWVWVARVGEFPNTSQPHLAKVQLLEPRWDLSERLGPSSGQLGEPLADGLVFVPATLAFNLGCDPLEVGELRIQRYLEGSIIPEDRGSCSLMSGPPFARELHIEIVSSPHYSANGDYDHVLYRHFHTPRVVQEGDVLCVPTVGQVEILEGSPEKLPRWREVFFKVKKAVGEAPDGPASAFLADTTHTSLYMAGSALSRVPLLPSGRSTPWDSLSPPGLEALVNELCAILKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCYSLCADSSGAVETKLQAAFSRARRCRPAVLLLTAIDLLGRDRDGLDEDARVVATLRHLLLDEDPVSNCPPLMVVATTSRAQDLPTDVHTAFPHELEVPVLSEEQRLSVLQALTAHLPLGQEVNLLQLARRCAGFVVGDLYALLTHTSRVACARIRASGLAGGLSEEDEGELCAAGFPLLAEDFGQALDQLQTAHSQAVGAPKIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGASEDRASQLRVLSAITRKFKLEASVSLVNVLDRCPPQLTGADLYSLCSDAMTTALKRRVRDLEEGLEMGSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC
What is the function of this protein?
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:23929341, PubMed:9539740).  Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (By similarity).  Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (By similarity).
What are the official names of this protein?
Peroxisomal ATPase PEX6, Peroxin-6, Peroxisomal biogenesis factor 6.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: T2EB_BOVIN
Sequence: MDPSLLRERELFKKRALSTPAVEKRSVSSEASSSKKKKAKLEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLEEILDETQHLDIGLKQKQWLMSEALVNNPKIEVVDGKYAFKPKYNLKDKKALLRLLDQHDQRGLGGILLEDIEEGLPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQDSGPKKVAPIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDIAPGK
What is the function of this protein?
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH.  Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).
What are the official names of this protein?
General transcription factor IIE subunit 2, Transcription initiation factor IIE subunit beta, TFIIE-beta.
What is the protein family that this protein belongs to?
Belongs to the TFIIE beta subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NANT_SALAR
Sequence: MSTSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHEGKAPVRTMVDILYRGEHRIINILMTFAAAAALWFCFAGNLQNAAIVAALGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPTYLKTELAYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFAIGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSGAVPFGSSKDAFVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: REP_BUCBP
Sequence: MLFNEHQKKAISYISGPCLILAGAGSGKTRVIINKIVHLIKICHFDPKCITAITFTNKAACEMKSRILNVLSVNVSNLVKISTFHALGLEIIKSEIELLNIKSNFTIFDEQDQISILQEIVSKEDRSFVRQIRQSISNWKNKLLCPNQVNKISNSSIEFKFFRYYELYNAYLKSSNILDFDDLIFLPTILLRDNKLSRERWNDKIKYLLVDEYQDTNFIQYKLIKLLSSKRSNFTLVGDDDQSIYSWRGANIHNFESLKHDYPNLRTIIMQHNYRSSGRILKVANALISNNLHFFNKKLFSNLDYGSIVEIISAKNEEDEARVILQTLMLHKSNYNAQYKDYAILYRSNYQVKIFEKFLIKFKIPYKILANISFFSRPEIKDLIAYLRLIINPDDNAAFLRVVNRPLRGIGAVTLQKLKEWSKKRNQSFFMASLDIGLESILPVHNLKSLQEFVYLIQTISYQIQLNPIEVLEKLVATIKYEKWLMRSLKFSKLYVASIKNISIVLNWIINELKYKIMNSKKFVMKYLIDIISEFILQNSLNEDIVINNDYVQLMTLHASKGLEFLYVFIVGVEEGVLPYYRNTTMENNIDEERRLAYVGITRAQKKLFLSYAIQRCQYGVVINTKPSRFLRELPQSDILWQKSKILNLNEKNNFLFKAYKKSLKKKLLR
What is the function of this protein?
Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA.  It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
What are the official names of this protein?
ATP-dependent DNA helicase Rep, DNA 3'-5' helicase Rep.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: ADHR_DROME
Sequence: MFDLTGKHVCYVADCGGIALETSKVLMTKNIAKLAILQSTENPQAIAQLQSIKPSTQIFFWTYDVTMAREDMKKYFDEVMVQMDYIDVLINGATLCDENNIDATINTNLTGMMNTVATVLPYMDRKMGGTGGLIVNVTSVIGLDPSPVFCAYSASKFGVIGFTRSLADPLYYSQNGVAVMAVCCGPTRVFVDRELKAFLEYGQSFADRLRRAPCQSTSVCGQNIVNAIERSENGQIWIADKGGLELVKLHWYWHMADQFVHYMQSNDEEDQD
What are the official names of this protein?
Alcohol dehydrogenase-related 31 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: SUA5_SCHPO
Sequence: METKIQTVDTRLISFEKPSNDSEHPFEHTRVSIPPSETRSALENAANILRNTDYPVAFPTETVYGLGADARRTEAVLSIYKAKNRPADNPLIVHVASLDQLRRLLLSAYPKAKSEVKNQAHDSEEIIPKVYLPLIKKFWPGPLSILLPVVDEANPPVSPIVTAGQKTFAVRMPQHPVALALISISDSPLAAPSANASTRPSPTLAKHVYNDLQGKIPLILDGGACGVGVESTVVNGLCDPPVILRPGGISLEEIQSSGGAWERTKVFVAKKSDMETDFIPQTPGMKYRHYSPTAKVLLFVNYTESDAYGVFEKYLSEQGITKEKQKIGVLCSKRWNEESFPSHCPFVFLHMGRDGHEITKNLFAQLRDLDLQGVDFVLVEGVSEENEGLAIMNRLGKAASVVFEGPSH
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.  Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame.  Also involved in telomere replication.  Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length (By similarity).
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein sua5, tRNA threonylcarbamoyladenosine biosynthesis protein sua5.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, telomere.
Protein: CRYAB_MESAU
Sequence: MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFSTATSLSPFYLRPPSFLRAPSWIDTGLSEMRMEKDRFSVNLDVKHFSPEELKVKVLGDVVEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQASGPERTIPITREEKPAVTAAPKK
What is the function of this protein?
May contribute to the transparency and refractive index of the lens.  Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.  In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).
What are the official names of this protein?
Alpha-crystallin B chain, Alpha(B)-crystallin.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Lysosome. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Localizes at the Z-bands and the intercalated disk in cardiomyocytes. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: SPX4_ORYSI
Sequence: MKFGKDFRSHLEETLPAWRDKYLAYKSLKKLIKNLPPDGDPPPVAAAAEVPAGDGDGDGGIALGNWFARVLDMELQKLNDFYIEREEWYVIRLQVLKERIERVKAKKNGAFTSKSEFTEEMLEIRKAFVIIHGEMILLQTYSSLNFAGLVKILKKYDKRTGGLLSLPFTQRARHQPFFTTEPLTRLVRECEANLELLFPIEAEVLESASSSAKLQPQNDDAASHDPASSVDVETSDVYRSTLAAMKAIQGLRKASSTYNPLSLARFFHGEDGEACSGAITSESDSYSDSQIEDAEDDDKEVQSREQNTAQNAAEGQPRDE
What is the function of this protein?
Inositol polyphosphate sensor that associates with transcription factors to regulate Pi starvation responses (By similarity).  The SPX domain provides a basic binding surface for inositol polyphosphate signaling molecules (By similarity).  Interacts with PHR2 to inhibits its translocation to the nucleus and repress its DNA-binding activity, and then negatively regulate Pi signaling (By similarity).
What are the official names of this protein?
SPX domain-containing protein 4, Protein SPX DOMAIN GENE 4, OsSPX4.
Protein: APOE_CHLSB
Sequence: MKVLWAALLVTFLAGCQAAADAPIKVEQPVEPETEPELRPQTEWQSGQPWELALGRFWDYLRWVQTLSEQVQEELLSPQVTQELTTLMDETMKELKAYKSELEEQLSPVAEETRARLSKELQAAQARLGADMEDVRSRLVQYRSEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLASQPLQERAQALGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQISLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGASTAPVPSDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: NCOA7_CHICK
Sequence: METKEEKKERRQGYFARLKKKRQAKQNTETVSANSPGSPVSKTPAEKDDESKVILEQISSSGDNCKFAGEKETVPEKEKRKKKYNQLKDIRRTELKRYYSTDDNQNKTNEKKEKKMVSQKPHGTIEYTAGNQDTINSIALKFNITPNKLVELNKLFTHTIVPGQILFVPETSVARLPSFSPGAPISPSSSDAEYDKLPDADLARKAFKPVERVLSSTSEEDEPVVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYNDISHMKIKDALPSDIPKDLCPLYRPGEWEDLSSEKDINPFSKFKSLSKEKRQQNGDSPNVPGAKQINPSDKEKSADFEVLQSSESTGSIKSKSLEFYNNITATEHLEKFAADPHVKEPSEEKNVSDIRTKEDSLSGGGDDFIDLEKVPSPMDRGLDRKISLMEGLLADPRELGRTKQQVTKPTTEVQEHFTVDSLEKKDSVEPKADLDLELCEKQDVIPEVNKCVSSPTGKVETALDTKKELEKDKLIEFYLNKDGSGSQSSEDLHKAEIQKGENNKAIGIDLTLSCSKSQADEVHTVKSMELDSCCVGRKAASLESSAAAAEEKDLKESLDSSLVPAVDKTCQETQLDNQSEVRLWLLQKIQVPIEDMLPSKEEKSKTPPMFLCIKVGKPMRKSFVSQSTTVSQQYSKKIKQPEYWFAVPREIITVEEAKRRKSVCSYYGEEDDDDALPVLKHHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFRFSDHYYGTGETFLYTFSPNFKVFKWSGENTYFINGDMTSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFIIQDVEVWTFE
What is the function of this protein?
Enhances the transcriptional activities of several nuclear receptors.
What are the official names of this protein?
Nuclear receptor coactivator 7.
What is the protein family that this protein belongs to?
Belongs to the OXR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZNUC_EHRCR
Sequence: MFHKLLNKSEILAYDKKYVNNYIINVENLSFFYSKEKVIDDISFQVKFGEIVTILGPNGGGKTTLIRILVGIYRNYIGVIKYAKNFIIGYLPQHFSVNSLIPMTVKYFLNSSYTKSKRKLKLSDVLKDINIEKILDRQMSEISHGELQLVLLARCLMLNPDIIILDEPVSCMDVNAKDSFYKLINKLISIYNLSVIMTSHDLHFVMSNSYRVICINRSIYCEGSPSEIVKNEKFLKMFSSYA
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZSC21_PANPA
Sequence: MMTKVLGMAPVLGPRPPQEQVGPLMVKVEEKEEKGKYLPSLEMFRQRFRQFGYHDTPGPREALSQLRVLCCEWLRPEIHTKEQILELLVLEQFLTILPQELQAWVQEHCPESAEEAVTLLEDLERELDEPGHQVSTPPNEQKPVWEKISSSGTAKESPSSMQPQPLETSHKYESWGPLYIQESGEEQEFAQDPRKVRDCRLSTQHEESADEQKGSEAEGLKGDIISVIIANKPEASLERQCVNLENEKGTKPPLQEAGSKKGRESVPTKPTPGERRYICAECGKAFSNSSNLTKHRRTHTGEKPYVCTKCGKAFSHSSNLTLHYRTHLVDRPYDCKCGKAFGQSSDLLKHQRMHTEEAPYQCKDCGKAFSGKGSLIRHYRIHTGEKPYQCNECGKSFSQHAGLSSHQRLHTGEKPYKCKECGKAFNHSSNFNKHHRIHTGEKPYWCHHCGKTFCSKSNLSKHQRVHTGEGEAP
What is the function of this protein?
Strong transcriptional activator (By similarity).  Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity).
What are the official names of this protein?
Zinc finger and SCAN domain-containing protein 21.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.