PharMolix/UniProtQA huggingface dataset:
Protein: VP4_ROTYO
Sequence: MASLIYRQLLTNSYSVDLHDEIEQIGSEKTQNVTVNPGPFAQTRYAPVNWGHGETNDSTTVEPILDGPYQPTTFTPPTDYWILINSNTNGVVYESTNNSDFWTVVVAVEPHVNPVDRQYTVFGENKQFNVRNDSDKWKFLEMFRSSSQNEFYNRRTLTSDTKLVGMLKYGGRIWTFHGETPRATTDSSNTANLNDISIIIHSESYIIPRSQESKCNEYINNGLPPIQNTRNVVPLSLSSRSIQYKRAQVNEDITISKTSLWKEMQCNRDIIIRCTFGNSIVKLGGLGYKWSEISYKAANYQYNYLRDGEQVTAHTTCSVNGVNNFSYNGGSLPTDFSVSRYEVIKENPYVYVDYWDDSKAFRNMVYVRSLAANLNSVKCTGGSYNFSLPVGAWPVMNGGAVSLHFAGVTLSTQFTDFVSLNSLQFKFSLTVDEPPFSILKTLTGNLYGLPAANPNNRNEYYEISGRFSLISLVPTNDDYQTPIMNSVTVRQDLERQLTDLREEFNSLSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDLTKSMATSVMKKFRKSKLATSISEMTNSLSDAASSASRSVSIKSNISTISNWTNVSNDVSNVTNSLNDISTQTSTISKDLRLKEMITQTEGMSFDDISAAVLKTKIDMSTQIGKNTLPDIVTEASEKFIPKRSYRILKDDEVMEINTEGKVFAYKIDTLNEVPFDVNKFAELVTNSPVISAIIDFKTLKNLNDNYGITRIEALNLIKSNPNVLRNFINQNNPIIRNRIEQLILQCKL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: APOC2_TAPTE
Sequence: MGARHLLALLLVLLVLGFEVQGAQVPQQDEAANTTLLTQVQESLLSYWDSTKAAAQDLYKKTYLTTMDEKIRDMFSKSTAAVSTYVGIFTDQLLSLLKGED
What is the function of this protein?
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma.  Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.  Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
What are the official names of this protein?
Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOC_THISH
Sequence: MSERLEKLAARLTERFKAAGGKVDSAYGELTLTVPAAAMTDTAKALRDDLGFEMLIDLCGVDYQEYGVAEWSTEESSNQGFSRGVEKATFGRFIFDEVAERKAHEGPRFAVVYHLLSISANQRLRMKVFCEDEEFPVVSTVTDVWTSADWYEREAFDLFGIMFEGHPDLRRILTDYGFVGHPFRKDFPLVGHVEMRYDPEQARVVYQPVSIEPRVLVPKVIRQDHRYVHESAQEKSADA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SSTT_HAES1
Sequence: MNKSYLYSFFFHGSLVKRISVGLLLGLLLALIAPSLQGVLGFNLAEKAGFLGKIFVRSLRAVAPILVFLLVISAIANKQLGTKSNMKSIVVLYLLGTFLAALTSVLFSFALPTEIALKTQEGSLSPPNEVSEVLSTLVLNVVDNPINALFNANFIGILFWAIGLGIALRYASDTTKNVMNDFSEAVSRIVHFIISFAPIGVFGLVAETLTDKGLGALLDYMQLLVVLIGSMLFTAFVINPILVFWKIRRNPYPLVWTCVRESGLTAFLTRSSAANIPVNMELSKRLKLDEETYSVSIPLGANINMAGAAITITVLTLAAVHTLGIEVSFPTAVLLSVVASICACGASGVAGGSLLLIPLACSLFGIPNDIAAQVIGVGFVIGVLQDSTETALNSSTDVIFTAAVCWSEENKNS
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: B1T1_LOXSN
Sequence: FALAHMVNDFDILKSYLDEGANGVETDITFSDEGEPEYAFHGVPCDCKRWCRRTVGFNEYLQHVRDLSTPGNPKFREHFIAIVLDLKLNGLSQEALAHGGMRLADKLIAYYWAHGRNATRITFIVSVPKTSEKVFLKTFLEEIKAVGYDDMLSKVAFDFTDNGDFSETQKVFEGLGIHEHIWASDGITNCIPMLFRGTSRLEDLIRQRDVPGYKYISKVYAWTYDKETSVVKALELGVDGVMTNYADFVIGIINKPEHSSKYRLATYQDNPFEKFVKSA
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LspiSicTox-betaIE3i, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RNFD_VIBCM
Sequence: MAFFIASSPHLRSKRSTADVMRWVLACALPGLIAQTYFFGYGTLIQLLLAISVAVALEAGIMLLRKRSPISALRDYSAVVTAWLLAVAIPPLSPWWVVVIGLIFAIVIAKHLYGGLGQNPFNPAMIAYVVLLISFPVQMTSWMAPIKLTAEPSSLVDSFSLIFGGFDSDGLSLQQIRTGIDGITMATPLDAFKTSLKAGHTMSETLTQPQFSGFAGIGWEWVNIAYLLGGLILLKLRIIRWHIPMAMLAGLVFTALLAQLFAPGTTASPMIHLLSGATMLGAFFIATDPVSASTTDKGRLIYGFFIGAMVFLIRSWGGFPDGVAFAVLLANMCVPLIDYYTKPRTYGH
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIMM_CELJU
Sequence: MSAKSSNLVSVGRITAVYGIKGWVKVHSYTEPQDNLFEYHPWWVKTRHGVKQVEIDEARPHGDAYVAHIKGVDDRDLAMAYTAADIAVERDLLPELEDGEYYWNQLEGLSVFTVFGGEQRLGVVTKLLETGANDVLVVQGDAQSIDQRERLIPYVPGQFVLSVDLDSKRILVDWDPEF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBLN1_BOVIN
Sequence: MLGVVELLLLGAAWLAGPARGQNETEPIVLEGKCLVVCDSNPTSDPTGTALGISVRSGSAKVAFSAIRSTNHEPSEMSNRTMIIYFDQVLVNIGNNFDSERSTFIAPRKGIYSFNFHVVKVYNRQTIQVSLMLNGWPVISAFAGDQDVTREAASNGVLIQMEKGDRAYLKLERGNLMGGWKYSTFSGFLVFPL
What is the function of this protein?
The cerebellin peptide exerts neuromodulatory functions.  Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity).
What are the official names of this protein?
Cerebellin-1, Precerebellin.
What are the subcellular locations of this protein?
Secreted. Postsynaptic cell membrane.
Protein: BL1S4_CANGA
Sequence: MALQDESLGIDQLSVDYDYLVYRISDRVKSLELEATRLVQRQNELVGQVSERVIDENIERFRGVLRGLDELEEYFAMMEQIGMITDSFKERLDSAMAALK
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit CNL1, BLOC-1 subunit CNL1, CNO-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Punctate pattern.
Protein: PTH_HALMA
Sequence: MKQAIVARADIGMGEGKLAAQVAHASLSAYEDAGPKPRKAWKGAGQKKVVLKATSESELFELADVAEREGLPHAVVRDAGHTQLDPGTVTALAVGPAEDELVDRVTGDLPLF
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAMTB_XENLA
Sequence: MSSEKIFLEGESCQSSWHNATAGYDETDTHLEILGKPVMERWETPYMHSLATVAASKGGRVLEIGFGMAIAATKLEQCNIEEHWIIECNDGVFKRLQEWATKQPHKIVPLKGLWEDVVPTLPNGHFDGILYDTYPLSEETWHTHQFNFIKGHAYRLLKPGGVLTYCNLTSWGELLKTKYNDIEKMFQETQTPQLVDAGFKCENISTTVMNLVPPEDCRYYSFKKMITPTIIKV
What are the official names of this protein?
Guanidinoacetate N-methyltransferase B.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
Protein: ATPD_CLOD6
Sequence: MINVIANRYAEALFQLGEEENSTDVLFKELEKVVDMMTKVSKDFYKVLKSPLVSKSEKKNLVEIIFSKEVSSNIKNFLKVLVDKDRISYLEDIELAYKELLNKKNNVIDGVAISAIPMSETDIKELEVKLSNKYNKNVTIENVVDKTILGGVLVRIGNEQIDGTVKTRLDKMKEKLSEVIS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LPXK_AERHH
Sequence: MLERLWYAKSGWRWLLAPFALLFAIISGTRRYAYRHGWRKGYRSSLPVIVVGNISVGGNGKTPVVVWLVEQLQARGYRPGVVSRGYGGKAPHYPYRLDAASTTAQAGDEPVLIARRCGCPVVVAPKRADAVRLLEQSGEVDIIITDDGLQHYALARDIELVVVDGARRFGNACLLPMGPLREPVTRLKRVDAIICNGGEPGRGEYPMRLVADVPRRVRDEAPLAAPLSGPVDALAGIGHPPRFFATLEGLGYQLDQRVAYGDHHPFDRDELVGRFAGKPLLMTEKDAVKCRSFALDNWWYLPVSAELPASLLDTLLHKLGAGGKGQGATQAQG
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: DUT_MOUSE
Sequence: MPCSEDAAAVSASKRARAEDGASLRFVRLSEHATAPTRGSARAAGYDLFSAYDYTISPMEKAIVKTDIQIAVPSGCYGRVAPRSGLAVKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERISYPDLEEVQTLDDTERGSGGFGSTGKN
What is the function of this protein?
Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (By similarity).  Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity).  Essential for embryonic development (PubMed:30987342).
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL23_CUPMC
Sequence: MTQVAKNDHRLMQVLLAPVVSEKATLVADKNEQVVFEVARDANKAEVKAAVELLFKVEVQSVQILNQKGKQKRFGRFMGRRNHVKKAYVSLKPGQEINFEAEAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: ISPE_YERP3
Sequence: MTTANQPICPSPAKWPSPAKLNLFLYITGQRADGYHQLQTLFQFLDYGDQLTIEPRDDNQIRLLTPIAGVENEQNLIVRAAKMLQKHPGNTPVPRGADISIDKCLPMGGGLGGGSSNAATVLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAFAEGIGEKLQPAEPVEKWYLVIHPGVNIPTPIIFSDPELKRNTPIRPLAALLSTPYANDCEPIARKRFREVEQALSWLLEYAPSRLTGTGACVFAEFDTESSARQVLSIAPEWLHGFVARGVNVSPLHRVRSGKIESSERR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PA2B3_NAJMO
Sequence: NLYQFKNMIHCTVPSRPWWHFADYGCYCGRGGKGTPVDDLDRCCQVHDNCYEKAGKMGCWPYFTLYKYKCSQGKLTCSGGNSKCGAAVCNCDLVAANCFAGARYIDANYNINFKKRCQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows several activities.  It shows strong anticoagulant activity, probably by binding to coagulation factor Xa (F10) and inhibiting the formation of the prothrombinase complex (PubMed:15922780), shows direct hemolytic action, causes neuromuscular blockade with a gradual contracture and a decreased sensitivity to ACh and KCl, abolishes twitches evoked by indirect stimulation earlier than those by direct stimulation (in the mouse phrenic nerve-diaphragm preparation), and causes myonecrosis when injected intramuscularly (PubMed:3615669).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 CM-III, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BBOF1_XENLA
Sequence: MPKLKVKAGKGKKGKRKKAGKNEHRLDKESEVERARSNAALWEARLKVTEFSRVEYRDAARSLAQNNEDLTKQQYKLEKDMVEVIGFLKKQDLEKDELIEKLQQNLIAQKKSAQDEREKLVELYSKQIAHLEENYSQKTNEMQIIQSEFKLMREFRRQKVELEKELDEVKESLWRANQDHKETLARMERRFFEEKQRLEKEAEKKIMMLAEKAHSEAIIQLDEARKSVFKENVRLKEAFSYHLKEMKDIKKSKKMQEDAKLHLLQEKETNDLLVQEKVSQVSQKKVQIQELQQNVKALECALERMTMEMEKDAQGKEHQALLQEQAGNVELQKLQKVLHMKEREMNRIKKLARNILEERTEVESFFLEALWQVKQEIATSRNYYRQVAQSAYTSKMIQASLGKDQYPKIRTFHNKEHSTNDVSHDLSEAEKWTHIQAGKVDIGDLTWEQKEKVLRLLFAKMNGFQSRKSPGLKPSPPADVSSIKEKEINTSNLEEKPEESSSTFITQSIPELPAPSLVLPHIQTGRCQVTG
What is the function of this protein?
Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow.  May act by mediating a maturation step that stabilizes and aligns cilia orientation.  Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
What are the official names of this protein?
Basal body-orientation factor 1, Coiled-coil domain-containing protein 176.
What is the protein family that this protein belongs to?
Belongs to the BBOF1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to a polar structure adjacent to the basal body.
Protein: PSAC_LACSA
Sequence: MSHSVKIYDTCIGCTQCVRACPTDVLEMIPWDGCKAKQIASAPRTEDCVGCKRCESACPTDFLSVRVYLWHETTRSMGIAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: FZD5_HUMAN
Sequence: MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPRRGHKSGGAMAAGDYPEASAALTGRTGPPGPAATYHKQVSLSHV
What is the function of this protein?
Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549).  Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity).  In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549).  Functions in the canonical Wnt/beta-catenin signaling pathway.  The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).  Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).
What are the official names of this protein?
Frizzled-5, Fz-5, hFz5, FzE5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
Protein: FPG_PARXL
Sequence: MPELPEVEVTRRGIEPYVSGRKVERVEVRTPALRWPIPADLAKTLRGRVVRKVERRGKYLLFEIDAGWFIVHLGMTGTLRVLRHVPHPPAAAKHDHVDWIFDEFILRYRDPRRFGAVLWHPREAGDVLEHPLLAGLGVEPFSPAFSGALMHRLTRGRKVSVKQALLAGEIVVGVGNIYASESLFRAGIRPATAAGRVSLVRYDLLADAVRVTLAAAIEKGGSTLRDFVGSNGESGYFQLDYFVYDRAGLPCRVCGTPIKQIVQGQRSTYFCPTCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: Y695_THEPD
Sequence: MKVVVRAPFYPTESLEKVLSSIFNLFDAPKESCAVVGEGKGRYIECVFHNHKPLEKFRRLLRQQRILDAARSYVERGLREGEVKFYLNKQAAFAGKVSFCTYEAGESPLGSIIVVIELGKCSPDEFLNWLAPRTVNGKPVGEVSELKCLEQGSG
What are the official names of this protein?
UPF0201 protein Tpen_0695.
What is the protein family that this protein belongs to?
Belongs to the UPF0201 family.
Protein: GUC1B_MOUSE
Sequence: MGQQLSWEEAEAAGEMDVAELQEWYKKFVVECPSGTLFMHEFKRFFKVTGNEEASQYVESMFRAFDKNGDNTIDFLEYVAALNLVLRGSLEHKLKWTFKIYDKDRNGCIDRLELLDIVEAIYKLKKACRAELDLEHQGQLLTPEEVVDRIFLLVDENGDGQLSLTEFIEGARRDKWVMKMLQMDINPGCWITQQRRRSAMF
What is the function of this protein?
Stimulates two retinal guanylyl cyclase (GCs) GUCY2E and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2E and GUCY2F when free calcium ions concentration is elevated (By similarity).  This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).  May be involved in cone photoreceptor response and recovery of response in bright light (PubMed:25673692).
What are the official names of this protein?
Guanylyl cyclase-activating protein 2, GCAP 2, Guanylate cyclase activator 1B.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=Subcellular location is not affected by light or dark conditions.
Protein: PSTB_METKA
Sequence: MTAFEVRDLRVYYGEEEALKGITLDIPEKKITTIIGPSGCGKSTFLRCLNLMIKEIPYARTEGEVIFDGENVLEYEDEADIIAHRRRVGTVFQHPNPFPWMSIYDNVAYGLRLMGMDEDEIEDRVYEALEKAALLDQVEDRLDDPASALSGGQQQRLCIARALAMRPEVLLMDEPTSDLDPIATRKIEETVMELKGEVTIVFVTHLLPQAYRIGDYTAFFLHGELVEANSTEKLFTDPQDERTKEYIEVEFGPS
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y2604_PSEAE
Sequence: MQEQQYQLNSAVAEQREVSGVLRNTYGLLALTLAFSGLVAYVSQQMRLPYPNVFVVLIGFYGLFFLTVKLRNSAWGLVSTFALTGFMGYTLGPILNMYLGLPNGGSVITSAFAMTALVFFGLSAYVLTTRKDMSFLSGFITAGFFVLLGAVLVSLFFQISGLQLAISAGFVLFSSAMILYQTSAIIHGGERNYIMATISLYVSIYNLFISLLQIFGIAGGDD
What are the official names of this protein?
Uncharacterized protein PA2604.
What is the protein family that this protein belongs to?
Belongs to the BI1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.