PharMolix/UniProtQA huggingface dataset:
Protein: RNFE_AZOVD
Sequence: MSHCGAPSVPEPEKKVPWQYFTSALWQYNVALVQMLALCPTLAVTTTATNGLGMGLATTLVLVMTNALISSMRHTISPEVRNPVMIGVIAGVVTLTDMAMNAWMHELYKVLGLFIALIVTNCAVLGRAESFCLRNPVIPSILDGAGMGAGFTAVLVVIGGIREILGSGTLFSQASSLLGSHFKWMEITVIPDFQGILLAILPPGAFIVLGFLLAAKRVIDRKRAERRQQTHGELVVLQ
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HOOK1_CHICK
Sequence: MEGKAADPLLCDSLILWLQTFNTAAPCRNVQDLTNGVAMAQVLHQIDVAWFDASWLNRIKEDVGDNWRIKSSNLKKILQGIMDYYHEFLDQQISEELIPDLNKISENSDPTELGRLMQLILGCAVNCERKQEHIQNIMTLEESVQHVVMTAIQELMSKEAMGPSASDVSSEMEQQLKKALEDLQEAIAEKEELAQRCQELDLQVAALQDEKNSLVSENEILNDRLEQLDDSLDDPNTVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEDLEKQLIELQHRNNELTSLAEESRALKDENDILRAAADKASKLESTVEVYRKKLQDLNDFRRQVKSLQETNMMYMHNTVSLEDELREANAARAQLETYKRQVQELHNKLSEESKRADKLAFEMKRLEEKHEALVKEKERLVIQCDALKETNEELRYSQMQQDHLSRTDASRIKSHDNLAAELLPVEYREMFIQLQHENKMLLLQQEGSENERIMELQKQLEQKQWTVNELGTEKRLNKERIGELQQQIEDLQKTLQEQGSKTEGSSNLKQKLAAHMEKLSEVHDELQKKEAALAELQPDVSQNPQKIGELEAALRKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQITERDKKIEALEAEYKLAKLRDYEENLIVTAWYNKSLTLQKLGMEARLLGSGGACRDGPGRSFLAQQRHVTNTRRNLPVKVPSATSD
What is the function of this protein?
May function to promote vesicle trafficking and/or fusion.
What are the official names of this protein?
Protein Hook homolog 1.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton.
Protein: RL17_LARHH
Sequence: MRHRLANRKLNRTSSHRLAMLRNLANSLLRHEQIVTTLPKAKELRRVAEPLITLGKKPSLANRRLAFDRTRDREIVVKLFDELGPRFANRNGGYLRILKYGFRQGDNAPMALVELVERPEVEAAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RFCL_ARCFU
Sequence: MLWVEKYRPKTLEEVVADKSIITRVIKWAKSWKRGSKPLLLAGPPGVGKTSLALALANTMGWEAVELNASDQRSWRVIERIVGEGAFNETISDEGEFLSSRIGKLKLIILDEVDNIHKKEDVGGEAALIRLIKRKPAQPLILIANDPYKLSPELRNLCEMINFKRLTKQQVARVLERIALKEGIKVDKSVLLKIAENAGGDLRAAINDFQALAEGKEELKPEDVFLTKRTQEKDIFRVMQMIFKTKNPAVYNEAMLLDESPEDVIHWVDENLPLEYSGVELVNAYEALSRADIFLGRVRRRQFYRLWKYASYLMTVGVQQMKEEPKKGFTRYRRPAVWQMLFQLRQKREMTRKILEKIGKYSHLSMRKARTEMFPVIKLLLKELDVDKAATIAAFYEFTKEELEFLVGEKGDEIWKYVEKHGMHRIEDETFLESFVKAEKEEKEESVEEVAEEKPEEEREEPRARKKAGKNLTLDSFFS
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.  The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA.
What are the official names of this protein?
Replication factor C large subunit, RFC large subunit, Clamp loader large subunit, afRFC large subunit, afRFCla.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcL subfamily.
Protein: RUVB_STRPM
Sequence: MARILDNDVMGNEEFSDRTLRPQYLHEYIGQDKVKEQFAIFIEAAKRRDESLDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAVEKAGDLVAILNELEPGDILFIDEIHRMPMSVEEVLYSAMEDFYIDIMIGAGDTSRSIHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYQEKDLTEIVERTATIFEIKIDHEAARKLACRSRGTPRIANRLLKRVRDYAQIIGDGIITAQITDRALTMLDVDREGLDYIDQKILRTMIEMYQGGPVGLGTLSVNIAEERNTVEEMYEPYLIQKGFLMRTRTGRVATQKAYRHLGYPYQNT
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: VKGC_BOVIN
Sequence: MAVSARPARAPRGSDKVKKDKAAQTSGPRQGSRMGKLLGFEWTDVSSWERLVTLLNRPTDPAGLAVFRFLFGLMMVLDIPQERGLSSLDRRYLDGLEVCRFPLLDALQPLPLDWMYLIYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFVDAHHYWSVDGLLRARKRNAHVPLWNYAVLRGQIFIVYFIAGIKKLDADWVEGYSMEYLSRHWLFSPFKLVLSEEMTSLLVVHWCGLLLDLSAGFLLFFDASRPIGFVFVSYFHCMNSQLFSIGMFPYVMLASSPLFCSPEWPRKLVAHCPKKLQELLPLRTAPQPSTSCMYKRSRARGSQKPGLRHKLSTAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTPWLQPLLMDLSPWRTKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLQEGEKMQLPAGEYHKVYTVSSSPSCYMYIYVNTTEVALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNAPFHERLVRFLLRKLFIFRRSFLMTCISLRNLAFGRPSLEQLAQEVTYANLRPFEPAGEPSPVNTDSSNPNPPEPDSHPVHSEF
What is the function of this protein?
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
What are the official names of this protein?
Vitamin K-dependent gamma-carboxylase, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CLP1_MALGO
Sequence: MEDIVDDVRSSTYQVVENDACGTGKANLLSLSLLYLRSTLKWMIELDAGEAVAIRFVPDPISGHYGDAEVFGAPLVAGSQERWYTFGNEAKFAISSWGGAEVEILGAASTEYMADEPSPTYTYCTNLHLNLERARIRAREQLRTDPSLQKILEDMDVSERTIPASYEQHGAGASGSDLYRAAGQGPRVMIVGPESAGKTSLIKFLANYALRSPALANVKEGDDASRRAKHRSEPEIHPGPDVAHDDDDDDDVENRKDDEESGINDMKHPKNRKKHSSADSQAKKTLSDITGWWPMIVALDPSEGAVPVPGCVSAIPLTPMPTNWLPSPSPALPYGITTQTTGTLPPSVSTVQSVMPISLWMGKENVRENERHSRRVIDWLAYYIEKRLVKDWRARMSGLLLDMPGVITADARTRYGFIQYCVRAFKIDTIVVLGHEKLNLELTRIYANDTSGHAPRIVKVPRSGGAVEVDEVYKQKLHDLQIRSYFYGMPPALTKEAAVTSMSMNDENTPASIPAGLDEHLGAVPTLSPYSTTIPLDLLSIYRVGQDRVAPSSALPIGAERVLSEMQVVKLDPVNSSNDMSMLLHSVLALVEPPPRNQSKDETSSPDDPGHHDYEDDELLGAAILGFVHVSDMDLHRKKLTVLSPKPGKLPSTTALIGNLQWQDM
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
mRNA cleavage and polyadenylation factor CLP1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS4_LEGPA
Sequence: MLVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKMQQLELICSMQKTGIPIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIKPENIVLALDVRVDTKVPLLAINGWQNNSTSSLWEVVSYYENYGIKNILCTDIACDGMMNGPNFDLYQQAVEYFPQIAWQASGGVRHMQDITTLNSLGISAVILGLMLYQDNVNFEELLC
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_BDEBA
Sequence: MLFPSIIAGLKHRGIRMAKKEKIEFPKIEWRDFSPAPIIGVDEVGRGCLAGPVYAAAVIFKSDALNDLVTDSKLLSEKRREELADLILKEHIVGIGSASVEEIDEINILNASLLAMKRAVEKLGVKSGHVLVDGNKKIPNLKGFEQSTIVKGDLRVAPISAASIVAKVTRDRLMKDLGVKYPHYGFEIHKGYSTPVHKQSIVDHGPCIAHRRSFAGVKEYV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPID_SHIFL
Sequence: MTALLRVISLVVISVVVIIIPPCGAALGRGKA
What are the official names of this protein?
ilv operon leader peptide, ilvGMEDA operon attenuator peptide.
Protein: SURF1_RICPR
Sequence: MKINFLILTTFIILTSLGFWQLSRLKEKKLFLDSIQSHIISPGINLEKVQENLLYHKVKITGQFLPNKDIYLYGIRLMAMEKDGYYLVTPFKTIADQVILVVRGWFSNRNKNIIMKATNNQIHEIIGVIMPSEKTLSYLPANDIKNNVWLTLDLKEASKALKLNLENFYIIAEGKDISNLDILLPLSLNHLALIKNDHLEYAITWFGLAIFLIVIYVIYRHSSNIPVPVNKQLKSLEQKNNQKN
What are the official names of this protein?
SURF1-like protein.
What is the protein family that this protein belongs to?
Belongs to the SURF1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNLJ_CHRVO
Sequence: MTIPGAGFAGPFAVREFPMTANELRAAELRELLNRYGHEYYVLDAPTVPDAEYDRLFRELQALEEAHPELAVSDSPTRRVGGAPLDEFVSVVHAVPMLSLSNAFSDMQLTDPAERHSELIQFDERVRKGLDAAEVEYATEPKFDGLAISLLYENGVLTRAATRGDGVAGEQVTENVRTIRAIPLKLDGANPPALLEVRGEVLMLKRDFERLNADQIARGDKTFANPRNAAAGSLRQLDSRITAQRRLSFFAYSIAQVGGADWPATHAGEMAWLKTLGFPVVMDSLRPVVSGAAGLAGYYEAVLTARAGLPFEIDGVVYKVNRRDQQEALGFVSRAPRWAIAHKFPAEEALTCVEAIEEQVGRTGAITPVARLKPVFVGGVTVTNATLHNEDEVRRKDVRVGDTVVVRRAGDVIPEVVSVVLAQRPMQPAEGGDLFSAGEEPRYPAYRLPTACPVCGSHVVREEGEAIARCSGGLSCRAQRSQAIQHFAGRRMMDIDGLGERYIDKLVEYGYVQGVADLYRLKLEDLLEMKRRADEDEGVTPETVKAGKVASKWAENLIEAIDASRAPPLARLLFALGIRHVGESTAKTLADWLGTMALIRRCPAALFAALPDIGGVVADSLADFFAEDNNEKALDALLAEVKPADEHAPSPKLRERLDDASLLARLAIPRLTEVRSQQLAAQRSLAWLGQSERRALLALELPAEVVNALADWLDEPGRRAALASLAGLRDEILASLPAAAEAAALPLEGKTLVLTGTLPTLSRDQAKALIEAAGGKVSGSVSKKTHYVVAGEEAGGKLAKAQELGVAILDEAGLQALLAGN
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PHT12_ARATH
Sequence: MAEQQLGVLKALDVAKTQLYHFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVSSIFDKKFPAPTYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAKNIKQATADMSKVLQTDIELEERVEDDVKDPRQNYGLFSKEFLRRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPKAATMNATHEVFRIARAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWIKPENRIGFVVMYSLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNQDKAKVDAGYPPGIGVKNSLIVLGVLNFIGMLFTFLVPEPKGKSLEELSGEAEVSHDEK
What is the function of this protein?
High-affinity transporter for external inorganic phosphate.
What are the official names of this protein?
Probable inorganic phosphate transporter 1-2, AtPht1;2, H(+)/Pi cotransporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. phosphate:H(+) symporter (TC 2.A.1.9) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CYB_RAPCA
Sequence: MTNIRKTHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTADTATAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTFLETWNVGVILPFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMVHLLFLHETGSNNPTGTSSDMDKIPFHPYYTIKDILGVLLLILTLMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILVLMPLLHMSKQRSMMFRPISQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFTLILVLMPIASTIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ACP_RHOPT
Sequence: MSEIGERVKKIVVEHLGVEPEKVVDSASFIDDLGADSLDTVELVMAFEEEFGCEIPDDAAETILTVGDATKFLEKNAKS
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACDH6_RHOOB
Sequence: MSENTRKVTVAVIGSGNIGTDLMIKVIRHSDVLQMGAMVGIDPDSDGLARARRLGVPTTAVGVHGLLELPNFDEIDVVFDATSAKAHAANAALLEPLGKRLIDLTPAALGPFVVPAVNLDEHRHAANVNMVTCGGQATIPIVAAVSRVTPVAYAEIVASIASKSAGPGTRANIDEFTETTSHAIETVGGARRGKAIIVLNPADPPLIMRDTVLCLISARDPATHDAIRNSIQAMVEHVATYVPGYRLKQQVQITPVPDGQPVHTLLASGDTAAPTHQVSVFLEVEGAAHYLPAYAGNLDIMTSAAVRYAESVADTIAAPAATQGATR
What are the official names of this protein?
Acetaldehyde dehydrogenase 6, Acetaldehyde dehydrogenase [acetylating] 6.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: MNMA_AROAE
Sequence: MSSNTDPNGMKVVVGMSGGVDSSVTALLLKQQGFDVTGLFMKNWEDDDDDEYCSTRQDLVDVASVCDVIGIDLEVVNFSAEYKDRVFADFLREYEAGRTPNPDVLCNSEIKFRCFLDHAMALGADRIATGHYAQVREWANDGRSEYQLLKAEDGTKDQSYFLYRLNQAQLAKTLFPLGALYKRDVRRIAAEAGLHVAEKKDSTGICFIGERPFREFLMRYLPMRPGEIRNLDDGRVIGEHQGLMYHTIGQRKGLHIGGIKGRQDGAGEHDAWYVAGKDVKANVLYAVQGHEHPALLKTRLSATDLHWIAGRDPHTHWVYTAKPRYRTPDMPCEIEALVDGGAEIVFAEPQWALTPGQSVVVYESKVCLGGGVIA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ELP1_HUMAN
Sequence: MRNLKLFRTLEFRDIQGPGNPQCFSLRTEQGTVLIGSEHGLIEVDPVSREVKNEVSLVAEGFLPEDGSGRIVGVQDLLDQESVCVATASGDVILCSLSTQQLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPILEQQIHQDDFGESKFITVGWGRKETQFHGSEGRQAAFQMQMHESALPWDDHRPQVTWRGDGQFFAVSVVCPETGARKVRVWNREFALQSTSEPVAGLGPALAWKPSGSLIASTQDKPNQQDIVFFEKNGLLHGHFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLQREESSIPKTCVQLWTVGNYHWYLKQSLSFSTCGKSKIVSLMWDPVTPYRLHVLCQGWHYLAYDWHWTTDRSVGDNSSDLSNVAVIDGNRVLVTVFRQTVVPPPMCTYQLLFPHPVNQVTFLAHPQKSNDLAVLDASNQISVYKCGDCPSADPTVKLGAVGGSGFKVCLRTPHLEKRYKIQFENNEDQDVNPLKLGLLTWIEEDVFLAVSHSEFSPRSVIHHLTAASSEMDEEHGQLNVSSSAAVDGVIISLCCNSKTKSVVLQLADGQIFKYLWESPSLAIKPWKNSGGFPVRFPYPCTQTELAMIGEEECVLGLTDRCRFFINDIEVASNITSFAVYDEFLLLTTHSHTCQCFCLRDASFKTLQAGLSSNHVSHGEVLRKVERGSRIVTVVPQDTKLVLQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIYDHNPKVFLGNVETFIKQIDSVNHINLFFTELKEEDVTKTMYPAPVTSSVYLSRDPDGNKIDLVCDAMRAVMESINPHKYCLSILTSHVKKTTPELEIVLQKVHELQGNAPSDPDAVSAEEALKYLLHLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCGPEYFPECLNLIKDKNLYNEALKLYSPSSQQYQDISIAYGEHLMQEHMYEPAGLMFARCGAHEKALSAFLTCGNWKQALCVAAQLNFTKDQLVGLGRTLAGKLVEQRKHIDAAMVLEECAQDYEEAVLLLLEGAAWEEALRLVYKYNRLDIIETNVKPSILEAQKNYMAFLDSQTATFSRHKKRLLVVRELKEQAQQAGLDDEVPHGQESDLFSETSSVVSGSEMSGKYSHSNSRISARSSKNRRKAERKKHSLKEGSPLEDLALLEALSEVVQNTENLKDEVYHILKVLFLFEFDEQGRELQKAFEDTLQLMERSLPEIWTLTYQQNSATPVLGPNSTANSIMASYQQQKTSVPVLDAELFIPPKINRRTQWKLSLLD
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244).  The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).  Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).  ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity).  May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059).
What are the official names of this protein?
Elongator complex protein 1, ELP1, IkappaB kinase complex-associated protein, IKK complex-associated protein, p150.
What is the protein family that this protein belongs to?
Belongs to the ELP1/IKA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MUTL_EHRCR
Sequence: MSIILLDPRTINRIAAGEVIECPASVVKELVENSIDAKATAISITIERGGRNLIIVSDNGIGIKKEDMEIAFARHATSKLPDGDLTKVRSLGFRGEGLTSIAAVGKVKMVSKYRDSDTAWLMVFEGGEKTQELTPDALSCGTYIEVRDLFFATPNRLKFLRTEKAEVQSIIDMMNKLAMVNHNVMFSLFVDNKQVFKYLTQQSNIDRLSEIKTLGMEFCKNSLPVNVKEEQIQLSGYIGSPTLSRGKSSLIYTFVNSRPVYDNLLIGAVRYAYSDFIEKDKYPVVVLYLDIPCDQVDANVHPNKSEVRFQDKKLVYRTVVNAIKEVLSINLNTKLKSISEFENDHFVHASMVNSRNIGNSVSSEFFKCFQNRKPLLNNDVQKYSSKNVETDDQSLLDTNVSFCTDSKMITNKLKEERVYENSREHINKGDSKIEVSNFDILGEKKNFVNLANNLLQESPSIDSGKFNTSKKVPSDSLIDTYPLGYALCQIHSRYIISQTQDSIVIIDQHAAHERLTYEYMKQVMAKEGIKRQILLIPEIIEMNNHLDLELLVEYKEKLLKLGLLIEPLGNLSVIVREVPALFGSFDVKSLIINIVDSIMEVGDTLFLDDKIKDICGTIACYSSIRSGRKLKIEEMNAILRNMENTAHSGQCNHGRPTYVELNLVEIDRLFSRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: MQO_ECO27
Sequence: MKKVTAMLFSMAVGLNAVSMAAKVKASEEQETDVLLIGGGIMSATLGTYLRELEPEWSMTMVERLEGVAQESSNGWNNAGTGHSALMELNYTPQNVDGSISIEKAVAINEAFQISRQFWAHQVERGVLRTPRSFINTVPHMSFVWGEDNVNFLRARYAALQQSSLFRGMRYSEDHAQIKEWAPLVMEGRDPQQKVAATRTEIGTDVNYGEITRQLIASLQKKSNFSLQLSSEVRALKRNDDNSWTVTVADLKNGTAQNIRAKFVFIGAGGAALKLLQESGIPEAKDYAGFPVGGQFLVSENPDVVNHHLAKVYGKASVGAPPMSVPHIDTRVLDGKRVVLFGPFATFSTKFLKNGSLWDLMSSTTTSNVMPMMHVGLDNFDLVKYLVSQVMLSEEDRFEALKEYYPQAKKEDWRLWQAGQRVQIIKRDADKGGVLRLGTEVVSDQQGTIAALLGASPGASTAAPIMLNLLEKVFGDRVSSPQWQATLKAIVPSYGRKLNGDVAATERELQYTSEVLGLKYDKPQAVDSTPKPQLKPQLVQKEVADIAL
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: PNP_GEOSL
Sequence: MTEHKVNVEFGGRTITIATGKWAKQASGAVVVSCGDTVVLVTAVATKSAREGQDFFPLTVNYQEKAYAGGKIPGGFFKREGRPSDNETLTSRFIDRPIRPLFPESFLNDTQIMATVVSADQDNDPGILAMIGASAALEVSDIPFLGPIAGVKVGRVDGQFVCNPTVEQLEKSDLEIVVAASRDAVIMVEGGAAEASEKDVLEAIFFGHAAVQPIIEAQTDLRKLAGVPKREVAATSVDEALKTRVKDLAYAGIKEAVRIVAKQERHNRIGEITAQTLETLLPEYEGRESEIKGFLGDFEYELVREHIIKDGYRIDGRDTTTIRPISIEVSMLPRAHGSALFTRGETQALVASTLGTSIDEQRIDSLYGETRKRFLLHYNFPPFSVGETSFRLAPGRREIGHGMLAERALERVVPKHEDFPYTIRIVSDILESNGSSSMATVCGGALAMMDAGVPIKAPVAGIAMGLIKEGEGIAILSDILGDEDHLGDMDFKVAGTEAGVTAIQMDIKITGVTREIMEKALLQARDGRLHILGKMNQAIAAPRTDLSPYAPRITTIWVKTDKIRDVIGSGGKNIRGITEATGVSIDIEDSGRINIASTSKEACDKAIKMIRDLTAEAEEGKLYMGTVKKVMDFGAFVEIFPGTDGLVHISELDTERVKNVTDVLNEGDKVLVKCIGIDKQGKIKLSRKEALGAVLPE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRE1_DICDI
Sequence: MDIVKNYLIAFDQYTANFRWESGVTPLSSYVFPFSTSVIYVLVIFALQAIMKNKKGMVLKGFSIIHNINLIILSFSMMSGVMYAAYQQYLEQGAFSLVCEQSSQSVQGRIGFWIYIFYLSKYYELVDTVILALKKKPIIFLHIFHHMAMVPVTWQWLHDQWLVGSWWCTLVNSFIHVLMYYYYLQTTLGNPCWFKKYITKAQIVQFLTGTAMVSYWFVIRDSEKCQAPLSPAIVSNTINSFFIILFGKFYYDSYKSNSRRQEKLNKVE
What is the function of this protein?
Could be implicated in synthesis of very long chain fatty acids.
What are the official names of this protein?
Elongation of fatty acids protein sre1, 3-keto acyl-CoA synthase sre1, Protein SRE1 homolog, Very-long-chain 3-oxoacyl-CoA synthase sre1.
What is the protein family that this protein belongs to?
Belongs to the ELO family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DCUP_RICTY
Sequence: MKQISNSLRNSNKIPIWFMRQAGRYLPEYKKVRETTKNFLDFCFDVNKATEVTLQPIRRYGLDAAIIFSDILVLPSALGWEVDFKENIGPVLKQFKSQKDFQYLQRDSNNKLENVFKIIKKVKEKLPSNTSLIGFAGSPWTVMSYMLEGKGKRDFITSKKFVYENKILAKDLLNFITEKTADYLINQAKSGADILKIFDSWSGVLAEDDFTEFVIEPTKKIILKVKEVFINIPIITFPKGAGLLYEKFIKEVPIDILAVDQMVPLEKMKEWSNKVIVQGNLDPVVLLTNKEIIEEKTYKILQGMKGKNFIFNLGHGILPETPPENVEFLTKYIRLYEKKNSNSTF
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_STRP3
Sequence: MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELHEINPIGIVLSGGPNSVYADNAFGIDPEIFELGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSNDCPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEITKIRETVGDRKVLLGLSGGVDSSVVGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPGPGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFAQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RL18_CHESB
Sequence: MVSKVSVTRRAGRVRRKLKAVATERPRLSVYRSSKHIYAQVIDDVKGHTLAAASSLDKDLREKLKTGADVDAAGVVGKLIAERAKKAGIDKVVFDRGPYIYHGRVKALADAAREGGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PANB_EXIS2
Sequence: MHTMTPLLKKQQAGEKLVMLTAYDYPSAKLAEAGHVDLLLVGDSLGNVILGYDSTIAVTVDDMVHHAKAVRRGAPATFMVVDMPFASYHGSFDRTLEAAARIFQESGADALKLEGAGDILTTIRRLTEAGMPCVAHLGLTPQSVGVLEGFKVQGKSLAAAEQLIADSLAAEQAGAKMLVLECVPHPLAKRVQELLTIPVIGIGAGADVAGQVLVYHDILTYGVGRLPKFVKAYADWNTSGTEAIARYVEDVKNGTFPELAHSFLMDEELIGALYGGFKE
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.