PharMolix/UniProtQA huggingface dataset:
Protein: LPXK_PSEPF
Sequence: MAMSDRLLAAWYHGHPALTLLRPLEWLYRRVVAGKRQRFLDGEGEIYQSPVPVIVVGNITVGGTGKTPMILWLIEHCRRHGLRVGVVSRGYGAKPAQLPWRVQADQTADIAGDEPLLIVQRTGVPLMIDPDRSAAVRALLDSEPLDLILSDDGMQHYRLARDLELVLIDAARGLGNRRCLPAGPLREPAERLQSVDGVLFNGALEDRDGGFAFRLKPSALVNLRSGERRPLDHFPPGQAVHAVAGIGNPQRFFNTLEALDWRPVPHAFADHAEYSVQALSFTPSLPVVMTEKDAVKCRAFAADDWWYLTVDAVPSPAFVAWFDTQLMRLLPDRLLP
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: END4_STAA1
Sequence: MLLGSHVSMSGKKMLEGSAIEAYEYGETTFMIYTGAPQNTRRKSIEDLNITKGHEVMEKYGLSNIVVHAPYIINIANTTKPETFNLGVDFLQQEIERTQAIGAKDIVLHPGAHVGAGVDAGINKIIEGLNEVLTNDNNVRIALETMAGKGTEIGRSFEELARIIDGVHNNERLSVCFDTCHTHDAGYNVKEDFDGVLNEFDKIIGVDRIKVVHVNDSKNDRGAQKDRHENIGFGYIGFDALNYIVHHDSFKDIPKILETPYVGEDKKNKKPPYKLEIEMLKQQQFDPELKNKVMQQ
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: HTPX_BARQU
Sequence: MNIMRTAMLLAFMTALFMGVGYLIGGSNGMVIALLMAGGLNFFSYWNSDKIVLNMYGARKVDQHSSPVYYKIVSDLAQRASLPQPKVYIIDSAQPNAFATGRNPQNAAVAASTGLLEQLSAEEVAGVMAHELAHIEHRDTLTMTLTATIAGAISMLGNFAFFMGGQRNSSEHSHGAGALGGLIALFVAPFAAMLVQMAISRTREYAADRRGAEICGNPLWLASALSKIAGGGHTVYNEEAEHNPATAHMFIINPLKGEGADSLFSTHPATANRIAALRRQAEEMKGAMPKSMGWSEEENFHKKNSNLDYDGLNRSAQTSIFGNQENNAVQRIKKRPSWLRYEDSKRSRS
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD_HAEIN
Sequence: MKIILLGAPGAGKGTQAQFIMNKFGIPQISTGDMFRAAIKAGTELGKQAKALMDEGKLVPDELTVALVKDRIAQADCTNGFLLDGFPRTIPQADALKDSGVKIDFVLEFDVPDEVIVERMSGRRVHQASGRSYHIVYNPPKVEGKDDVTGEDLIIRADDKPETVLDRLAVYHKQTSPLIDYYQAEAKAGNTQYFRLDGTQKVEEVSQELDKILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity).  It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H. influenzae.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_PSEP1
Sequence: MAMNKDKPWTLYLLAVGLAVLAAVQFGLFSQPAVQAIPYSQFLQLLDQQKVSDLHIEHERILGRLQEPIDGHSVFSTVRVDPALSEQLGRSGVAFSGVVEDNTVATVMGALMPLLMLLALWYFLFHGLGQKQGLGGLMGVGKSRARVYVEHDTQVTFADVAGIDDVKGELTEIVSFLKNKAWYARLGAHVPKGTLLVGPPGTGKTLVAKAIAGEAAVPFFSISGSEFVEMFVGVGAARVRDLFDQARQAAPCIIFIDELDALGKMRGVGSFGGNDEKEQTLNQLLAELDGFDPREGVVLLAATNRPEVLDPALLRAGRFDRQILIDRPDRKGRLAILKVHLHKIIYKNDLDCERIAEITPGLTGADLANLVNEAAIVATRRSSQWVELQDFTAAVERLVAGIERKGSVLRSDERQVVAYHEMGHALAASSLPAMDPVHKVSIIPRAAGSLGYTLQRPTDDRYLISTQMLRDRLVVLMAGRAAEHLVFGQVSTGAADDLGRATDIARQLVTRFGMSPVLGQAVLERQQAGYLGDSLLRQERKDYSEQTAREIDLAVRGLLEEAYGRARALLEQRRDDLDAGARLLLAKETITPEEFPALQPQANEPATYVLVDATK
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: CANB1_DROME
Sequence: MGNETSLPMDMCSNFDADEIRRLGKRFRKLDLDNSGALSIDEFMSLPELQQNPLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVRGDKLSKLRFAFRIYDMDNDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTICFADKDEDGKISFDEFCSVVGNTDIHKKMVVDV
What is the function of this protein?
Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.
What are the official names of this protein?
Calcineurin subunit B type 1, Protein phosphatase 2B regulatory subunit 1.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
Protein: RL27_HELAH
Sequence: MAHKKGQGSTQNNRDSAGRRLGVKKFGSEFVRAGNIIVRQRGTKMHPGNNVGMGKDHTLYALTDGVVKFEYKDKSRKKVSVISQNFGE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SMO2A_XENLA
Sequence: MADDKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGSF
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
What are the official names of this protein?
Small ubiquitin-related modifier 2-A, SUMO-2-A.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIBA_COLP3
Sequence: MSVNFVDSCRLPTHLGEFEMYGFVEESGQEHIMLTYGEITPDKPLLIRLHSECLTGDSLFSMRCDCGYQLETALENIVDAGQGALLYLRQEGRGIGLINKIKAYHLQDDGADTVEANEQLGFAADLRRYTMCKPMLEHFRVNKVKLLTNNPKKVQALKDLGIEVVEQMPIQVGRNQYNHEYLNTKAERMGHMMTHGLLSDLG
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: RLMN_SALPK
Sequence: MSEQIVTPESSTPVVLNNETKINLLDLNRQQMREFFKNLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLTNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDTIRDEIVPINKKYNIETFLGAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKETPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEVIDIKAI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y004_SIFVH
Sequence: MRIKVEVEGKINTNKIEDIFTALETNKINVTKSQKLQQIEEIKELKQEIKQEIENTLGEKIHIEELIITRTGTYLLRGKIEK
What are the official names of this protein?
Uncharacterized protein 4.
Protein: CEL_HUMAN
Sequence: MGRLQLVVLGLTCCWAVASAAKLGAVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPADPINLYANAADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIRF
What is the function of this protein?
Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499).  Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate.  Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity).  Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499).
What are the official names of this protein?
Bile salt-activated lipase, BAL, Bile salt-stimulated lipase, BSSL, Bucelipase, Carboxyl ester lipase, Cholesterol esterase, Pancreatic lysophospholipase, Sterol esterase.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: GUAA_MOOTA
Sequence: MIGENKQLAEIVLVLDFGGQYNQLIARRVREAGVYSEMIPYNTPLEKILARRPRGIIFSGGPASVYSLGAPRIDRALYESGIPILGICYGMQLMAHDLGGRVEGASGREYGKTQLEITAADPLFAGLPESIQCWMSHGDYISAPPPGFQVTARSAYTPVAAMSDPARKLYGVQFHPEVKHTPMGQEILRRFLFQVCGCRGDWSVSSFIEDQVAAIRRQVGNGRVLCALSGGVDSSVAAALVHRAVGDRLTCVFVNHGLLRQGEAEQVQRAFGQAMGMNIVYVDASRRFLEKLTGVTDPEEKRKIIGHEFIRVFEEEARKLGRVDFLVQGTLYPDVIESGTETAAVIKSHHNVGGLPEDMELELIEPLRLLFKDEVRRVGEELGLPEEIVWRQPFPGPGLAIRILGEVTPEKLEILRQADAIVTEEIRRAGLYREIWQSFAVLPSMKSVGVMGDERTYAYPIVLRAVTSDDAMTADWARLPYDLLERISSRIVNEVRHINRVVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ATPG_PROM9
Sequence: MANLKEIRDRIVSVKNTRKITEAMRLVAAAKVRRAQDQVLKSRPFADKLARVLENIQSRVQFEAVDSPLLSKRDVKTISLVCITADRGLCGGYNTNIIKKVEIRYAELIKQGYEPNLILVGKKAIGYFQNRKDRYIIKTTFKELEQVPTAKDSEGITSEVLAEFLSENADRVEIIYTKFITLVSCAPVVQTLLPLDPQGIADENDEIFRLTTKDSKLLVEKSNIEKSDSEKLPSDIVFEQSPDQLLDSLLPLYLQNQVLRALQESAASELACRMTAMNNASDNAKELASTLNLTYNKARQAAITQEILEVVGGSAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: PDC_ASPPA
Sequence: MEGETLPLAQYLFKRLLQLGVDSIFGVPGDYNLTLLDHVVPSGLKWVGNCNELNAGYAADGYSRIKDIGAVVTTFGVGELSAINAIAGAYAEKAPVVHIVGTPMRASQESRALIHHTFNDGDYQRFDAIQEHVTVAQVSLSDHRTAPSEIDRILLQCLLHSRPVRIAIPVDMVPVLVPVAGLSSKIQIPPAVRQPQAEEAALNAVLKRIYSSKKPMILVDGETRSFGMLQRVNHFIQTIGWPTFTSGFGKGLVDETLPNVYGVCTLHQKAFVDSCDLVLVFGPHFSNTNSYNYFLKPADEKSVLFSPNSIQVNKDVFRDLPVGYFIEQLTQQLDISRIPTHKHDLVHPSLRTLPEVSPTDLVTQTGGFWKRFSPFLRTGDIILGETGTPGYGVNDFILPPQTRLFKPATWLSIGYMLPAALGASHAQRDLVASDQYHSLSNPRTILFIGDGSFQMTVQELSTIIHQKLNVIIFLINNDGYTIERCIHGRNQAYNDVAPWRYLKAAEFFGADQDGEYKASTWEVRTWADLDRVLNDSQLADGKGLRMVEVFMERLDAPDVLMGLLNNQVLRENAQSRL
What are the official names of this protein?
Pyruvate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: XOATE_ORYSJ
Sequence: MTTTGSTPPRKNRSNVTGGEGGSLEEYAWRAAGEAAAAKKATRAWGVSVSLRSHFSSLVLLLLLLLVALAVSATTKNGDPAETPHAPPLPPPASIKLPSSSSSGGGECDLFSGRWVYDEAAYPLYRESACRVMSEQSACEKYGRTDLRYQHWRWQPHGCDLPRFDAEKFLGKLRNKRLVFVGDSLNRNQWASMLCLIDTGAPELHTSINSSRSLTTFKIHEYNASVDFYWSPLLVESNSDHPLRHRVADRTVRAASINKHAAHWTNADVLVFNSYLWWQRPAMKVLWGSFDNPAAVVAAAAEEGDEYAVSKVIDSLRAYELAVRTWADWMEFHVDRARTQLFFMTMSPTHLRSDEWEDAAAAAAGGNHGCYGETEPIAAEEYRGTSGTDMAFARAVEAEARRLGERSVAVRLINVTRLSERRKDAHPSVHRRYWDPVTDEQRRNPSSYADCIHWCLPGVPDVWNQLLYAHIVS
What is the function of this protein?
Xylan acetyltransferase required for 2-O- and 3-O-monoacetylation of xylosyl residues in xylan (PubMed:29569182).  Catalyzes the 2-O-acetylation of xylan, followed by nonenzymatic acetyl migration to the O-3 position, resulting in products that are monoacetylated at both O-2 and O-3 positions (By similarity).
What are the official names of this protein?
Xylan O-acetyltransferase 14, Protein trichome birefringence-like 3, OsTBL3.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: ASPH_BOVIN
Sequence: MAPRKNAKGGGGNSSSSSSGSPTGCTSGGSSSPGARRETKQGGLKNGRKGGLSGSSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLAKAKDFRYNLSEVLQGKLGIYDADGDGDFDVDDAKVLLGLKEKPAPKPTVPPEEADMYPWLEDQVLESPGRQNIEDEVYEQVQSLDETVYSEPGENLPQEPEGPAEELQPDDHVFVGSDADDRYEPMGTGAVHEETEDSYHIEETASPAYSQDMEDMMYEQENPDSSEPVVVDDAERTYQETDDVTYRDYDEQDHAVDNSNTILEEPHMPPAEEQQEVPPETNKKADEPGKKGKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFEELVRKYPQSPGARYGKAQCEDDLAEKRRSNEILRRAIETYQEAASLPDAPTDLVKLSLKRRSDRQQFLGHMRGSLLTLQKLVQLFPDDTALKNDLGVGYLLIGDNDSAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYRWYELGHQRGHFASVWQRSLYNVQGLKAQPWWTPKETGYTELVKSLERNWKLIRDEGLAAMDRTHGLFLPEDENLREKGDWSQFTLWQQGRKNENACKGAPKTCSLLDKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETRTWEEGKVLIFDDSFEHEVWQDAASFRLIFIVDVWHPELTPHQRRSLPAI
What is the function of this protein?
Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.
What are the official names of this protein?
Aspartyl/asparaginyl beta-hydroxylase, Aspartate beta-hydroxylase, ASP beta-hydroxylase, Peptide-aspartate beta-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: HBSAG_HHBV
Sequence: MGHTQAKSTTDRRVEGGELLLQHLAGRMIPPEFSGPITTAGKFPTIQHVMDHIDSVEELRTLQAGGHWPEGTARRLGLDQPRPTPPPITWTEEEDKKAKEFFKQYQENRPKPAETAPPPITELHAAEPPQWKISPEDPLLKAKALIPVKEPEVPILKVPKLTNKKKMGATFGGILAGLIGLLVGFFLLTKILEILRKLDWWWISLSSPKEKMLCAFQNTGAQTSPHYVGSCPWGCPGFLWTYLRLFIIFLLLLLVAAGLLFLTENKSTIFEKLQWESVSALSSSIYSLLPSEPKSLVALTFGLFLIWTTSSSVTQVLVTLTQLATLSALFFKNSG
What is the function of this protein?
Truncated S protein may be involved in translocation of pre-S domain through the virion membrane.
What are the official names of this protein?
Large envelope protein, L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen.
What is the protein family that this protein belongs to?
Belongs to the avihepadnavirus major surface antigen family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: PROB_CITBB
Sequence: MRKELLKKVKRVVVKIGSGVLTGENGGVDPRFLDGLAAQVAELSGQGTEVVIVSSGAVAAGRQALGLPDRPRTLPQKQAAAAVGQSRLMRAYEEAFSSYDLKVAQILLTRDDLANRRRFQNARGTLDTLLACGIIPVINENDTVVVDELKFGDNDNLSALVTNLVEAQLLLIMTDIDGLYTADPRTDPNATLIHQVGAVTRELERGAGGSGTSVGTGGMATKLAAAKKVVKSGVAAIIFAGRGERTLSRVMKGELLGTLFLPAGESLNRRKHWIAFTIKPAGSIVVDAGARDVLSRHGRSLLPSGIAQVEGRFDRGACVRVLDPEGVEFARGITDYSSQEVEKIRGHQSSEIEGILGFRYGDDVIHRDNLVLL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTPB_MYCTU
Sequence: MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
What is the function of this protein?
Essential virulence factor that promotes mycobacterial survival within host macrophages (PubMed:14617138, PubMed:16256440, PubMed:20167798, PubMed:29888212, PubMed:36227980).  Acts as a phosphatase that possesses triple substrate specificity toward phosphotyrosine, phosphoserine/threonine and phosphoinositides (PubMed:10986245, PubMed:16271885, PubMed:17584180, PubMed:36227980).  Supports mycobacteria survival during infection by modulating the normal host signaling pathways, attenuating the bactericidal immune responses and promoting the host cell survival (PubMed:20167798, PubMed:29888212).  Inhibits host pyroptosis by disrupting the membrane localization of host gasdermin-D (GSDMD): acts by catalyzing dephosphorylation of phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol 4-phosphate, thereby inhibiting the membrane targeting of GSDMD and subsequent cytokine release and pyroptosis (PubMed:36227980).  Inhibits host inflammatory responses and apoptosis through impeding the NF-kappa-B and MAPK signal pathways and TP53/p53 expression in the macrophage (PubMed:29888212).  Blocks the IL6/IL-6 production by down-regulating ERK1/2, p38 and p65 activity (PubMed:20167798, PubMed:29888212).  Prevents macrophage cell death by activating the Akt pathway and blocking caspase 3 activity (PubMed:20167798, PubMed:29888212).  Reduces the expression of iNOS in activated macrophages and inhibits the generation of destroying reactive nitrogen intermediate NO (PubMed:29888212).
What are the official names of this protein?
Triple specificity protein phosphatase PtpB, MPtpB, Phosphoinositide phosphatase, Protein-serine/threonine phosphatase, Protein-tyrosine phosphatase B, TSP PTP.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Secreted. Note=Further investigation is required to determine whether PtpB is direct substrate for SecA2, the ESX/type VII secretion system, or an alternate mechanism.
Protein: HOA2_BURL3
Sequence: MSLAGKKITVHDMSLRDGMHPKRHQITLDQMRNIARGLDAAGVPLIEVTHGDGLGGASVNYGFPAHTDEAYLSAVIPELKQAKVSALLLPGIGTVEHLRMAHELGVGTIRVATHCTEADVSEQHIGLARTLGLDTVGFLMMAHMSSPEQLVVQAKLMESYGANCIYITDSAGHMLPDDVTARISQVRDALKPETELGFHGHHNLAMGVANSVAAVAAGANRIDAAAAGLGAGAGNTPMEVFVAVCDRMGIETGVDVFAISDVAEDLVVPIMDAPIRLDRDALTLGYAGVYSSFLLFAKRAEAKYGIPARDILVELGRQRLVGGQEDMIEDAALTMVRAREVVA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 2, HOA 2, 4-hydroxy-2-keto-pentanoic acid aldolase 2, 4-hydroxy-2-oxopentanoate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: THII_ECODH
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTEQEVVEVETVNGFGPNDVILDIRSIDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNKTWLLWCERGVMSRLQALYLREQGFNNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCOA1_PIG
Sequence: MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDEVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAIMGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEEFMRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPPVNPSISPAHGVARSSSLPPSNSNMVSTRVNRQQSSDLHSSSHSNSSNSQGSFGCSPGNQIVAGVALNQGQASSQSTNPPLNLNNSPMEGTGISLAQFMSPRRQVSSGLATRPRMPNNSFPPNIPTLNSPVSMTSTACNNSNRSYSNIPVTSLQSMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLNIQPAKAESKDNKETASILNEMIQSDNSSNDGKPLDSGLLHNNDRLSDGDNKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKEVLSCTGTSSSASANSSSGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVPGNSGIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPPPEEIKLESQSQFTADLDQFDQLLPTLEKAAQLPGLCETERMDGAVTSVTIKSEILPATLQSTTARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWANNTVTAVNQNKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEERPNLYSQPYSSPSPTANLSGPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAANAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRRRQLIQQQRAMLMRQQSFGNNLPPSSGLPVPMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAENPEATLGNRNSMVNRGMTGNMGGQFGTGINPQMQQNVFQYPGSGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAMGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQNMNPMMGQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADGTQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTAGPQTPQAQQKSLLQQLLTE
What is the function of this protein?
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.  Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs).  Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors.  Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear.  Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors.  Required with NCOA2 to control energy balance between white and brown adipose tissues.  Required for mediating steroid hormone response (By similarity).
What are the official names of this protein?
Nuclear receptor coactivator 1, NCoA-1, Steroid receptor coactivator 1, SRC-1.
What is the protein family that this protein belongs to?
Belongs to the SRC/p160 nuclear receptor coactivator family.
What are the subcellular locations of this protein?
Nucleus.