PharMolix/UniProtQA huggingface dataset:
Protein: ETF2_VACCT
Sequence: MRYIVSPQLVLQVGKGQEVERALYLTPYDYIDEKSPIYYFLRSHLNIQQPEIVKRHILLTLRMTQLKGYLGNLLDIKDDIIIYSHKNNLEYSYVDNTIFNPFVYTQKKTLLKNDSFLYNVYSGACDFLVIWVARACDTSIPEFGSYEDVDNNIIKFETMLMEVFPQLDLDITVESKFNNIFRTNLKLTGLKKIIQRVQDLDINYKSLLSRYDEHFINMTGNHFILNDEQLNLSIWDLDGTLALSSDGDTVMINNVKLFTDLVSDIDTQMERIKGDITYKVHLATPINSRIKLDIETSFIFIETATNNILLSSDKKISIILAKNHISIKVKNHIPNIEKYFTFLVIAINAMFNSVQKSADFTKVETVYWSRICQNTKNKNRKPIIINYLDPGMKKISNNFYRSDEKEVFINDNGIMFTCMDPLGKYNKVGFLNIFHDMRKYCIPCCFLHDQSHRSTFSSCVHQIDVEKKIVSPYILNFGKVVTESKMSFLPIIFDAFLNDGMTANMEQDNKRLKETSGYHIVRCCAGDDIVRLRTTSDIIQFVNEDKNILIVNDMVYFPMNASDIGKKIHILIQEIVHEVMIVKKKESSDKIDFFPPNYKLLKDLFPKQTIQTPIQSDAGMVLTTDGFYIDGKLFNEDLSSKYVTFTKNVIASDAVAKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from early gene promoters.  Is recruited by the RPO-associated protein of 94 kDa RAP94/OPG109 to form the early transcription complex, which also contains the core RNA polymerase.  ETF heterodimer binds to early gene promoters.
What are the official names of this protein?
Early transcription factor 82 kDa subunit, ETF large subunit, VETF A7 subunit, Vaccinia virus early transcription factor large subunit, VETF large subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae VETF large subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity).
Protein: GLPK_STRPJ
Sequence: MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAGWVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAIVWQSRQTAPLAEQLKNQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGELLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEVRSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYARDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDIIDTMQVDTQTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGLSVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: YR370_MIMIV
Sequence: MTDTDFDNAADLHNLMIKTLEPEELYKKLENNLRKIETSYLDSKHCQDFKRKIEYYKIVPLISETKEIIKVLIQKIETLEIKEGSPKHSKIDEYMSVLSVPGLNLGEILVLVKELLTIDNDLPKNAHVHENIQDDVVYGNFSPN
What are the official names of this protein?
Uncharacterized protein R370.
Protein: SENC_RHOCB
Sequence: MNVSSKTAALAATAAVVVVVGISAAVTLVPHETDRFAACRKGTGSASAQIGGPFTLISETGATVTDRDVITKPSLVYFGYSYCPDVCPIDSTRNAAAVDLLAERGHDVTPVFISVDAARDTPPVLTEFTDLMSPKMIGLTGTPEQIDAAVKAYRAYYLIRNPGDPATLVDHSTQTYLMDPKLGFLDFYDRDATPEMVADSVGCFLDALQTPGDTPAAGNGN
What is the function of this protein?
Involved in both aerobic respiration and photosynthesis gene expression.
What are the official names of this protein?
Protein SenC.
What is the protein family that this protein belongs to?
Belongs to the SCO1/2 family.
Protein: TOP1_STAAW
Sequence: MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDCPKCNQYLVENKKGKTTQVICSNCDYKEAAQK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: MNTP_GEOKA
Sequence: MGAFIGEIIALSMMALALGMDAFSVALGMGLLRLRLRQMFYIGLTIGLFHILMPLAGMAVGRLLSREFGSVATYAGGALLLWLGGQMIIASFRRDDGSPLFPRGVGLLFFAFSVSLDSFSVGLSLGIFGARTMVTILLFGLFSMVLTWVGLFVGRHFQQWLGSYSEALGGSILLAFGLKLLFL
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CHS6_SOYBN
Sequence: MVSVEEIRKAQRAEGPATVMAIGTATPPNCVDQSTYPDYYFRITNSDHMNELKEKFKRMCDKSMIKKRYMYLNEEILKENPSVCAYMEPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNTGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIVGSDPLPAEKPLFELVWTAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIQKALVEAFQPLGIDDYNSIFWIAHPGGPAILDQVEAKLGLKPEKMEATRHVLSEYGNMSSACVLFILDQMRKKSIENGLGTTGEGLEWGVLFGFGPGLTVETVVLRSVTV
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 6, Naringenin-chalcone synthase 6.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: PCH2_CHICK
Sequence: MDEAAGDLKQALPNTCDNVQIHVEVHQKSNSTAKKEDIRMSVLKLLNRHNIVFGDYKWTEFDDGFLNSNVQSVSIVDTELKLKERQPIDLSKSSLTIHIFHLNEEGPSIENLEEENEDIVAANHWVLPAAEFHGLWESLIYDTEVKSHLLDYVTTTLLFSDRNVDSNLISWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSYRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQELIDDKDALVFVLIDEVESLTAARSAFKAGTEPSDAIRVVNAVLMQIDQIKRYPNVVILTTSNITEKIDMAFVDRADIKQYIGPPSAAAIFRIYLSCLEELMKCQIIYPRQHLLSLRELEMIGFVENNVSRLSLVLKEISRRSEGLSGRVLRKLPFLAHALYIQSPSVTMTAFLQALSLVVDKQFEERKKLADCV
What is the function of this protein?
Plays a key role in chromosome recombination and chromosome structure development during meiosis.  Required at early steps in meiotic recombination that leads to non-crossovers pathways.  Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity).
What are the official names of this protein?
Pachytene checkpoint protein 2 homolog, Thyroid hormone receptor interactor 13 homolog, Thyroid receptor-interacting protein 13 homolog, TR-interacting protein 13 homolog, TRIP-13 homolog.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. PCH2 subfamily.
Protein: YACG_PHOPR
Sequence: MLRLPVSQSNTPTTPIIVKCPTCKKEVEWGEQSPYRPFCTKRCQLIDLGEWAEEEKSIPGAPDLSDSDGWSDDMGY
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: FOLD_LACLA
Sequence: MNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQIYVRNKARQATAIGLNSSVVRLPETVSEQELLDLIEQYNQSEQWHGILVQLPLPEHISEEKVLLAIDPEKDVDGFHPMNMGRLWSGNPLMIPSTPAGIMEMFREYDVELSGKRAVVIGRSNIVGKPMAQLLMMADATVTIAHSKTENLRELTKEADVLVVAIGRDRMIKAEDVKEGAVVIDVGMNRDEDGKLHGDVDFDEVKDVASLITPVPGGVGPMTITMLMEQTVRAASRKMNENK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: LAN15_STAEP
Sequence: MKKELFDLNLNKDIEAQKSDLNPQSASIVKTTIKASKKLCRGFTLTCGCHFTGKK
What is the function of this protein?
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria such as staphylococci, enterococci and streptococci.  The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
What are the official names of this protein?
Lantibiotic epilancin 15X.
What is the protein family that this protein belongs to?
Belongs to the type A lantibiotic family.
Protein: GUAAB_HALMA
Sequence: MVNVDEFIEEAKAEIAEEIGDKHAVIGLSGGVDSSTAAALAYEAIGDQLTAVYVDTGLMRKGETDEIRETFDYMDSLRIVEAQDRFLDELEGETDPEEKRHIIGEQFIREFETVAREVDADYLVQGTIYPDRIESEGTIKSHHNVGGLPERIDFDGIVEPMRDLYKDEVREVARALDLEEIISERMPFPGPGLAVRIIGEVTEEKLAVAREANHVVEEELEEYEPWQALAAVIGKATGVKGDNRVHGWVVAVRSVESRDGMTARAQELDWDTLQRMQSRITGAHENVARVVYDVTHKPPATIEYE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit B, GMP synthetase.
Protein: ALLA1_DELRA
Sequence: ARPYSFGL
What is the function of this protein?
May act as a neurotransmitter or neuromodulator.
What are the official names of this protein?
Allatostatin-A1, AST-A1, ARPYSFGL-amide.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2240_ARCFU
Sequence: MSPEEILQKAIEMEREAIETYAEMKREADRETAELLDFLISQEREHIKLLNDRLKVVRLLKKE
What are the official names of this protein?
Uncharacterized protein AF_2240.
Protein: PMTD_ARATH
Sequence: MGHVNLPASKRGNPRQWRLLDIVTAAFFGIVLLFFILLFTPLGDSMAASGRQTLLLSTASDPRQRQRLVTLVEAGQHLQPIEYCPAEAVAHMPCEDPRRNSQLSREMNFYRERHCPLPEETPLCLIPPPSGYKIPVPWPESLHKIWHANMPYNKIADRKGHQGWMKREGEYFTFPGGGTMFPGGAGQYIEKLAQYIPLNGGTLRTALDMGCGVASFGGTLLSQGILALSFAPRDSHKSQIQFALERGVPAFVAMLGTRRLPFPAYSFDLMHCSRCLIPFTAYNATYFIEVDRLLRPGGYLVISGPPVQWPKQDKEWADLQAVARALCYELIAVDGNTVIWKKPVGDSCLPSQNEFGLELCDESVPPSDAWYFKLKRCVTRPSSVKGEHALGTISKWPERLTKVPSRAIVMKNGLDVFEADARRWARRVAYYRDSLNLKLKSPTVRNVMDMNAFFGGFAATLASDPVWVMNVIPARKPLTLDVIYDRGLIGVYHDWCEPFSTYPRTYDFIHVSGIESLIKRQDSSKSRCSLVDLMVEMDRILRPEGKVVIRDSPEVLDKVARMAHAVRWSSSIHEKEPESHGREKILIATKSLWKLPSNSH
What is the function of this protein?
S-adenosyl-L-methionine (SAM)-dependent methyltransferase (MTase) which mediates the methylesterification of the pectin homogalacturonan (HG) and thus regulates cell wall biosynthesis, at least in suspension-cultured cells.
What are the official names of this protein?
Probable pectin methyltransferase QUA3, Protein QUASIMODO 3.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: SURE_CERS1
Sequence: MRILITNDDGINAPGLEVLEQIALQLAGPDGEVWTVAPAFEQSGVSHAISYTHPMMIAKLGPRRYAAEGSPADCVLAALYDVLQGARPDLVLSGVNRGNNSAENVLYSGTVGGALEAALQGLPAIALSQFLGPETEGLADPFECARTHGARIVRLLLERGLWDGEDYRLFYNVNFPPVPAANLRGHRVAAQGFRRDTSFGVEPHMSPSGRRFLWIRGGAQQSPTLPGTDAAVNLEGFVSITPLRADLTAHDRLAELEALIG
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_ALBFT
Sequence: MNAVEIYTDGACKGNPGPGGWGAFLKSADSQKELFGGELGTTNNRMEMTAVIEALAALKRPCQVTLHVDSQYVLKGMTEWLAGWKARGWKTAAKQPVKNVDLWQRLDELVSTSGHRIDWRWVRGHNGDPGNEHADMLANRGVELALRQR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_SHIFL
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSIEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGKISRAQLQQIAQTKAADMTGADIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SYMC_SCHPO
Sequence: MATYKVQIPASFKTSYSFAESLKVSIAISAFSVKVPCEGAANCNSVRLVNSKEPEKYVSDANAIVSFLYWKQEEDLFNSFISSKLSILDWEALQFTPKAYTAKTKEDFAYLLSQLETIFKENEILNEFTPVEVALASDIYFCVLNGAPVREYPLLSAWYLKIEKQKPFVQALKLTFEKTLGQPAVTSTEKIPVSETTRNVNSQHLMRERVPGEKILPKSNERNILITSALPYVNNVPHLGNIVGSTLSADVFARYHRARNHNTLYICGTDEYGTATETKALEEGVSPKELCDKYHALHKEVYDWFEIDFDHFGRTTTPKQTGIAQHIFTKLYNNDYMAIDTMTQLYCEVHQGYLADRYVEGTCPKCGYDDARGDQCDGCGGLLNAFELIDPKCKLDRATPVKRETKHVFLSLDKLQPAVESWAMQSAVEGKWSNNGRSITESWLKEGLRPRCITRDLKWGTPVPLEEFKGKVLYVWFDATIGYISITANYTDEWEKWWRNPEQVKLYQFMGKDNVPFHTVIFPSSLLGTGEKWTMLHHINTTDYLNYETGKFSKSRGVGVFGNTAQDIGLSPSVWRYYLLSSRPETSDTMFTWKEFITRHNSELLANLGNFVNRTLKFTTAKYNGLVPHYLTDPSVGAGKLKADFVKDVNALLAKYNAALEASKLREGLRLAMEISARGNQYLQDNRIDNKCYLYERQKCADAIGYALNLIYLLAAIFYPYMPSTSTSIYKQLNAPAAAIPDTWELCLLPGHRIGEPEYLFTRIDESMEEEWRSKYGGNGSN
What are the official names of this protein?
Probable methionine--tRNA ligase, cytoplasmic, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_MYCVP
Sequence: MAHKKGASSSRNGRDSAAQRLGVKRFGGQVVKAGEILVRQRGTHFHPGVNVGRGGDDTLFATAPGAVEFGTKRGRKYVNIVRVTRAEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: DUT_SALA4
Sequence: MMKKIDVKILDPRVGQQFPLPTYATSGSAGLDLRACLDDAVELAPGATTLVPTGLAIHIADPSLAAVMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSIWNRGQDSFTIEPGERIAQMVFVPVVQAEFNLVEAFDATERGEGGFGHSGRK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ATPE_BORPE
Sequence: MATLHVDVVSAEEAIFTGEAKFVVLPGEAGELGILPGHTPLISRIRPGTVKIVRADEGEENIFVAGGILEVQPGSVTVLADTAIRAADLDEARAVAAREKAEEALRNAKDKADIAVVEAELAMLAAQAVAARKLRQGRTH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZDHC5_BOVIN
Sequence: MPAESAKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLSVSPAVPVYNAVVFLFVLANFSMATFMDPGVFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHITGVFGFGLLYVLYHMEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRTKSKGSLEVTESQSADAEPPPPPKPDLSRYTGLRTHLSLATNEESSLLGKDSPPTPTMYKYRPGYSSSSASAAMPHSSSAKLSRGDSLKEPPSIAESSRQPSYRSEPSLEPESFRSPTLGKGFPFDPLSSGSRSSSLKSAQGTGFELGPLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPEPPLGYTSPFLSARLAQQREAERHPRLAPGGPAPREPSPVRYDNLSRHIVASLQEREKLLRQSPPPGREEEPGLGDSGVQCTPGSGHAPRTSSSSDDSKRSPLGKTPLARPVAPRFGKPDGLRGRGLASPEPGLPAPYLGRSVSYSSQKAPPGVPETEEVALQPLLTPKDEVQLKTAYSKSNGQPKSIGSAPPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions.  Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs).  Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins.  Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2.  Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2.  Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes.  Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane.  Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis.
What are the official names of this protein?
Palmitoyltransferase ZDHHC5, Zinc finger DHHC domain-containing protein 5, DHHC-5.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LOLA_FRATM
Sequence: MKKIIICFIFVFSINVSFADATSELIDKIKNIHSMTANFNQKLIDGQTNNNLNSKGNMSLKKPQYFKWITTSPNHQEIVYNGTKLWIYDGDLDQLIIKKVSNDIAQFPYLILLSKNTNNINKLFTVTAQDNNSYILKPKNDQMIDSIKIKFTPNNQLEYLEISTSLNQFTKIEFNNVKTDVDISNTSFDFKAPQNTDIIDETKSA
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TPT_ARATH
Sequence: MESRVLLRATANVVGIPKLRRPIGAIHRQFSTASSSSFSVKPIGGIGEGANLISGRQLRPILLLDSSAINGGEKREILKPVKAAAAEGGDTAGDAKVGFLAKYPWLVTGFFFFMWYFLNVIFNILNKKIYNYFPYPYFVSVIHLFVGVVYCLISWSVGLPKRAPIDSNLLKVLIPVAVCHALGHVTSNVSFAAVAVSFTHTIKALEPFFNAAASQFIMGQSIPITLWLSLAPVVLGVAMASLTELSFNWLGFISAMISNISFTYRSIFSKKAMTDMDSTNVYAYISIIALFVCIPPAIIVEGPKLLNHGFADAIAKVGMTKFISDLFWVGMFYHLYNQLATNTLERVAPLTHAVGNVLKRVFVIGFSIVIFGNKISTQTGIGTGIAIAGVAMYSIIKAKIEEEKRQGKKA
What is the function of this protein?
Triose phosphate/phosphate translocator that transports inorganic phosphate, 3-phosphoglycerate (3-PGA) and triose phosphate.  Functions in the export of photoassimilates from chloroplasts during the day.  In the light, triose phosphates are exported from the chloroplast stroma in counter exchange with inorganic phosphate (Pi), generated during sucrose biosynthesis in the cytosol.  Involved in photosynthetic acclimation, a light response resulting in increased tolerance to high-intensity light.
What are the official names of this protein?
Triose phosphate/phosphate translocator TPT, chloroplastic, Protein ACCLIMATION OF PHOTOSYNTHESIS TO ENVIRONMENT 2.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. TPT (TC 2.A.7.9) subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: PUR9_SYNS9
Sequence: MAPVALLSVSDKSGLLPLAEALHRIHGYQLLSSGGTAKVLEQAGLPVTRVSEYTGAPEILGGRVKTLHPRVHGGILAKRGDAAHQNDLEQQNINFIDVVVVNLYPFRETVAKADVTWDQAIENIDIGGPTMVRSAAKNHADVAVLTSPDQYDRLLEAMAQAGGEVPAALRRQLALEAFQHTAAYDTAISRWMDQAVAADGSPWLEAVPLRQTLRYGENPHQKARWYSHAQQGWGGAVQLQGKELSTNNLLDLEAALAMVREFGYGSDGAEPAVQPAAVVVKHTNPCGVAIGSDVSTALTRALDADRVSAFGGIVAINGVVSAAAAGELKSLFLECVVAPSFSPEAREILAAKANLRLLELQPAAIDAAGPDHVRSILGGLLVQDLDDQAITPSEWTVASQRPPSSQEQQDLEFAWRLVRHVRSNAIVVASKGQSLGIGAGQMNRVGSARLALDAAGDQATGAVLASDGFFPFDDTVRLAASHGITAVIHPGGSLRDADSIKACDELGLAMLLTGRRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: GYRA_LEPBA
Sequence: MTEQNGQENESNKTLALNLSGRPDVAGALKAGVRVIPVEIEDQMKEAYLDYAMSVIVGRALPDVRDGLKPVHRRVLHAMNERAWRSDRPYVKSAKIVGEVIGNYHPHGDSAVYETMVRMAQTFSMRETLIDGQGNFGSVDGDNAAAYRYTEARLTKLAEELLKDIEKNTVSFSPNFDDTRQQPDVLPANFPNILVNGSTGIAVGMATNIPPHNLKEAVNAVIALIQNPDITLPELMKILPGPDFPTGGTIIGGEGLYQAYATGKGSIRIRSKVDIIENNKGREIIVIHEIPYQVNKKNMLEKIGDLVNEKIIEGISEILDLSDRKGIRVEIHVKKDANAQVILNQLFKLTQLQVSYGITMLAILDNRPKIFSLKEILKSYAEHRREVVVKRTEFDLDKAQKRAHILEGLRIALENIDEVIRIIRASKDVREAQSSLMATFSLSELQADAILEMRLQRLTSLEVQKIIDELEQVRILIADLEDILSKPDRVKSIICDELGKVSQSFGNTRTTEISLESLESSTFNAEDLIADEEVVVQLSEDMFIKRLPMDTFRRQKRGGKGVQGISTKREDFVKKLSSAMTHDNLMLFSNKGRAFLLKVYELPIATKEARGKSLKAVINLNDDEIITSLFTFRNFDESYLLMVTREGFVKKIQLDEFTNTKKSGIIAIGLRDGDELIDVIANPNNYDVFIGSKNGLAIRMNLNELRSQGRTASGVTAMKLEDDDSIAGITKVEPNTNLFCISENGFGKRTDFEEFSTKGRGGKGMTYLKIGEKNGRAVGISSVKEEDELLVITQSGMAIRVEVKTISMVGRSAMGVKVVNTKDEDFVKDFAVVRESDSDSAES
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFDF_DELAC
Sequence: MNFIHDPLTPRVLFGAGRLQSLGEELKLLGIRRVLVISTPEQRELANQVAALIPGSVAGFFDRATMHVPSQIVDQAASVARELGVDSYVAPGGGSTIGLAKMLALHSSLPIVAIPTTYAGSEMTSIYGVTENELKKTGRDRRVLARTVIYDPELTFGLPTGISVTSGLNAIAHAVEGLYAPEVNPILAIMAQQGIAALAKSIPTIRSAPTDLEARSQAQYGAWLCGSVLGNVSMALHHKLCHTLGGTFNLPHAETHTVVLPHALAYNTPAIPRANAWLQEALATREPAQALFDLAKSNGAPVSLQSIGMKEADLDRACELVMSAQYPNPRPLEKHAIANLLRRAYLGEPPQP
What are the official names of this protein?
Maleylacetate reductase, Chloromaleylacetate reductase.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.