PharMolix/UniProtQA huggingface dataset:
Protein: GYRA_SPICI
Sequence: MMKSENDGYDYDGKIRDIDIADEMKNGFLDYAMSVIVSRAIPDVRDGLKPVHRRIIYAMWDLKMTYEKQHKKSARIVGEVIGKYHPHGDTAVYEAMVRMAQDFSYRYPLIDGHGNFGSMDGDPPAAMRYTEAKMSKIAGEIIKDIEKETTIFIDNYDGSEEEPTFLPGYFPNLLVNGASGIAVGMATNIPPHNLNEVIDGVIAVTKNPEITTVELMKIIKGPDFPTG
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIUH_PSEAE
Sequence: MSASGRPQPMGRLTTHVLDSAHGCPGHGIKIELYRVEGQQLELIATTLTNHDGRCDQPVLQGEDFRPGVYQLVFNAGDYYRARGVQLPEPAFLDQVVLRFGIASADDHYHVPLLISPYSYSTYRGS
What is the function of this protein?
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
What are the official names of this protein?
5-hydroxyisourate hydrolase, HIU hydrolase, HIUHase.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
Protein: TRMFO_DESVH
Sequence: MEDSLTTITTAAIIGAGLAGCECALRLARAGVRVTLFEMKPAAFSPAHSNPDLGELVCSNSLRSDDIASGVGLLKQEMRELGSIVMEAADATRVPAGKALAVDRDLFARHITAVIEAEPGITLERREVASLDDPALASADVVVIAAGPLASAGLSDSLAAVVGGQLYFYDAIAPIIAAESIDLSIVFSGSRYGEPGEEGDYLNCPMNRDEYDAFYEALLAAEKVPSRDFEKELHFEGCMPIEALAERGPRTLVFGPFKPVGFTDPRTGTRPYAIIQLRAENRNKTAFNIVGCQTKLKYAEQERVFRMIPGLAGAEFVRHGSVHRNTYVNAPRVLADDLSLRADKRVFLAGQITGVEGYVESAACGMWLGMVLAARIQGRELPTPPPQTALGALLMHLRTPVKNFQPSNANFGLMPELGLKVKKRERKPLYSARAREHFVRWLAEAGVTPVIEPLLPTAPDTTGAAGEETTQAES
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGRB_SHISS
Sequence: MKKFRWVVLVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINQFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LPXC_DELAS
Sequence: MLQQRTIKTITRAVGVGLHSGQRVELTLRPAQPDTGIVFRRVDLPEPVDIPISAEAVTDTRMASTIGTGGAKVHTVEHLMSAIAGLGLDNIYIDITAEEVPILDGSSASFVFLLQSAGIELQKAPKRFIRVIRPVEVREGEGQNLKWARFDPYHGFKLRFEIDFAHPAVDSTGQCVEFDMGEDNYTRDIARARTFGFTKDVEMLRSHGLALGGGMDNAIVMDDYKVLNSDGLRYDDEFAKHKILDAIGDLYLIGRPLLAAYSAFRSGHGMNNQLLRALLAQPDAWELVSFDSERQAPKGFAQPARAW
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: METXA_SULAO
Sequence: MSLNLQTYTEHFTNPLYLESGRILEPYDITYETYGTMNEDKSNVVVVCHALTGSHHAAGLYEDETKPGWWDGFIGSGKAIDTDKYFVICSNVIGSCFGSTGPMSLQHPYQEPYRYKFPVVSIKDMVKAQRILFDRLDIHRVHAIVGGSMGGMQALQFAIHYPNFANKIIALATTHATQPWAIAFNKVAQESILNDPDFKQGYYDPDLLKEQGLSGMAVGRMAGHISFLSHESMREKFGRDYKLTDGLYELFGKFQVESYLEYNGYNFTKWFDPLAYLYITKAINIYDLSRGFDSLAEALKRVTSALYLVSFKNDLLFKNFEMKEIADELDKIGNKNHSYIDVKSDYGHDAFLVELNKFENHVKDALNG
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y704_STAAT
Sequence: MTHIIIDGDACPVVDSIIDLTTETGIFVTIIRSFSHFSNQLYPPHVSTLYVDDGPDAVDYKIVQLSTKDDIVVTQDYGLASLLVDKVLIVMHHNGKIYNSKNIQQLLDKRYMNAQIRKQGGRHKGPPPFTKQDQKVFEQSLLKVIHRIKELD
What are the official names of this protein?
UPF0178 protein USA300HOU_0704.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: NNRD_PHATC
Sequence: MKTWNDGKTIAIERCVLPLDASLHKGSSGRVGVLGGSARYTGAPYYAAMASLQAGADLAFVFCAQEATLPIKSYSPELMVAPVYSASDFDPVRLVDDMVNEIGDMLPKLHCLVVGPGLGRCPLVMKAVARVLELARSQQLHLVLDADALYMMSLPVYRSSLKGYDRLVLTPNVVEYQRLFPKSEDNNGESMEDASDEELAAATIVRKGAEDRIIVDQRQVMSCGEEGGLKRSGGIGDVLAGTLGTFTSWHAILLDREAVSTEDLPLSCWTACCAVKRATKRAFDDKRRAMTAPDVLHHLGQALDEMTRED
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ATP-dependent (S)-NAD(P)H-hydrate dehydratase, ATP-dependent NAD(P)HX dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
Protein: 4HYPE_PARDP
Sequence: MTQYIFPCIDGHTCGNPVRLVAGGAPRLEGATMLEKRAHFLREFDWIRTGLMFEPRGHDMMSGAILYPPTRGDCDVAVLYIETSGCLPMCGHGTIGTITMGIENGLIVPRTPGRLSIETPAGKVDIEYRQEGRHVEEVRLTNVPGFLYAEGLTAEVEGLGEIVVDVAYGGNFYAIVEPQKNFRDMADHTAGELIGWSLTLRAALNQKYEFTHPEHPQINGLSHIQWTGAPTVPGAHARNAVFYGDKAIDRSPCGTGTSARMAQLAARGRLGVGDEFWHESIIGSIFKGRIEAAATVAGRDAIIPSIAGWARQTGLNTIFIDAERDPFAHGFVVK
What is the function of this protein?
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp).  Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate, which would allow P. denitrificans to grow on t4LHyp as a sole carbon source (PubMed:24980702).  Also seems to be involved in an alternative catabolic pathway that degrades trans-4-hydroxy-L-proline betaine (tHyp-B) to alpha-ketoglutarate; this pathway would permit the utilization of tHyp-B as a sole carbon and nitrogen source (PubMed:24056934).
What are the official names of this protein?
4-hydroxyproline 2-epimerase, 4Hyp 2-epimerase, 4HypE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: ADA19_HUMAN
Sequence: MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAPKVSPREALKVKAGTRGLQGGRCRVEKTKQFMLLVVWTELPEQKPRAKHSCFLVPA
What is the function of this protein?
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell.  Also cleaves alpha-2 macroglobulin.  May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, Meltrin-beta, Metalloprotease and disintegrin dendritic antigen marker, MADDAM.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CAPP_PSEAE
Sequence: MPEIDARLREDVHQLGELLGDTIREQYGPRFLDKIELIRKGAKAARRGSAEGAQQLTATLDGLEEDELLPVARAFNQFLNLANIAEQYHRIRRRRPNEPEPFENLVLEELLGRLKDAGHAPGQLARQLAGLEIELVLTAHPTEVARRTLIQKYDAITAQLAAKDHADLLPEERSRIQQRLQRLVAEAWHTDEIRKVRPTPVDEAKWGFAVIEHSLWQALPNVLRHVDEVLLRSTGERLPLTAAPLRFASWMGGDRDGNPNVTASVTREVLLLARWMAADLYLRDIDRLAAELSMQQASPQLLARVGDSAEPYRALLKQLRERLRVTRNWTHQALAGEVPAAEGVLEHNRDLVEPLQLCHESLHACGMGVIADGALLDCLRRAATFGLFLVRLDVRQDSARHAAALSEITEYLELGSYDEWDEKTRLEFLLEELNSRRPLLPAHYQPSADTAEVLATCRAIAAAPPASLGSYVISMAGQPSDVLAVQLLLKESGVDWPMRVVPLFETLDDLDNAGPCMERLLTLPGYRSRLSGVQEVMIGYSDSAKDAGTLTAAWAQYRAQEKLVEICRQHEVELLLFHGRGGTVGRGGGPAHAAILSQPPGSVAGRFRVTEQGEMIRFKFGLPDIAEQNLNLYLAAVLEATLMPPPAPEPAWRAQMDRLAKDALLAYRRVVRDDPQFVEYFRLATPEQELGRLPLGSRPAKRREGGVESLRAIPWIFAWTQTRLMLPAWLGWETALLNAIERGEGALLGQMREQWPFFTTRIDMLEMVLAKADADIARLYDERLVPLELRPLGRRLRDLLSQAVRVVLGLTGQSLLLAHASETRESISVRNSYLDPLHLLQAELLARSRRCRGDACGGLEQALLVTVAGVAAGLRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: CENPA_MILFA
Sequence: MARISTSSNRPVPTSSALRRQRERDDGGRSTRAPGHNTGLYGNQPGDPPTIRSTNTTVKRRYRPGTKALREIRRYQRSSELLIRKLPFARLVKEVAENYIGADYGIRWQSNAVLALQEACEAFLVHLLEDTNLCAIHAKRVTIMQKDIQLARRIRGNI
What is the function of this protein?
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes.  Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore.  Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
What are the official names of this protein?
Histone H3-like centromeric protein CSE4, CENP-A homolog, CENPA homolog.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.
Protein: NTP1_VACCW
Sequence: MSKSHAAYIDYALRRTTNMPVEMMGSDVVRLKDYQHFVARVFLGLDSMHSLLLFHETGVGKTMTTVYILKHLKDIYTNWAIILLVKKALIEDPWMNTILRYAPEITKDCIFINYDDQNFRNKFFTNIKTINSKSRICVIIDECHNFISKSLIKEDGKIRPTRSVYNFLSKTIALKNHKMICLSATPIVNSVQEFTMLVNLLRPGSLQHQSLFENKRLVDEKELVSKLGGLCSYIVNNEFSIFDDVEGSASFAKKTVLMRYVNMSKKQEEIYQKAKLAEIKTGISSFRILRRMATTFTFDSFPERQNRDPGEYAQEIATLYNDFKNSLRDREFSKSALDTFKRGELLGGDASAADISLFTELKEKSVKFIDVCLGILASHGKCLVFEPFVNQSGIEILLLYFKVFGISNIEFSSRTKDTRIKAVAEFNQESNTNGECIKTCVFSSSGGEGISFFSINDIFILDMTWNEASLRQIVGRAIRLNSHVLTPPERRYVNVHFIMARLSNGMPTVDEDLFEIIQSKSKEFVQLFRVFKHTSLEWIHANEKDFSPIDNESGWKTLVSRAIDLSSNKNITNKLIEGTNIWYSNSNRLMSINRGFKGVDGRVYDVDGNYLHDMPDNPVIKIHDGKLIYIF
What is the function of this protein?
DNA-dependent ATPase that acts as a 5' to 3' translocase on single-stranded DNA and thereby plays a role in transcription termination of viral early genes (PubMed:27189950).  Uses forward translocation in concert with the viral RNA polymerase RAP94/OPG109 subunit and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex (PubMed:22069335).  In addition, acts as a positive elongation factor to assist transcription through problematic sequences (PubMed:9472022).
What are the official names of this protein?
Nucleoside triphosphatase I, Factor X, NPH-I, Nucleoside triphosphate phosphohydrolase I, NPH I.
What is the protein family that this protein belongs to?
Belongs to the helicase family. NPH I subfamily.
What are the subcellular locations of this protein?
Virion. Note=Virion core enzyme.
Protein: C7263_MEDTR
Sequence: MEVFMFPTGTTVIISVLSVLLAVIPWYLLNKLWLKPKRFEKLLKAQGFQGEPYNLSVLKDKSKQNYMLKLQQEDKSKSIGLSKEAAPSIFTPVHQTVRKYGNNSFLWEGTTPRVIITDPDQIKDVFNKIDDFPKPKLRSIAKYLSVGILDHEGKKWAKHRKIANPAFHLEKLKVMLPAFSHSCNEMISKWKELLSSDGTCEIDVWPSLQNFTCDVISRTAFGSSYAEGTKLFQLLKKQGFLLMTGRHTNNPLWGLLATTTKTKMKEIDREIHDSLEGIIEKREKALKNGETTNDDLLGILLQSNHAEKQGQGNSKNIGMTTQDVIDECKLFYLAGQETTSSLLVWTMVLLGRYPEWQARAREEVLQVFGNQNPNNEGLSQLKIVTMILYEVLRLFPPLIYFNRALRKDLKLGNLLLPEGTQISLPILLIHQDHDLWGDDAKEFKPERFAEGIAKATKGQVSYFPFGWGPRICLGQNFALLEAKIAVSLLLQNFSFELSPNYVHVPTTVLTLQPKNGASIILHKL
What is the function of this protein?
Involved in the biosynthesis of triterpenoid saponins.  Catalyzes three sequential oxidation steps at C-30 of 11-oxo-beta-amyrin.  Also able to catalyze sequential C-30 hydroxylation of beta-amyrin to produce 30-hydroxy-beta-amyrin and 11-deoxoglycyrrhetinic acid.
What are the official names of this protein?
11-oxo-beta-amyrin 30-oxidase, Cytochrome P450 72A63.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS10_SALRD
Sequence: MAAQQDIRIKLKSYDHTLIDKSAEKIIRTVKSTGAVVSGPVPLPTEKKIYTVLRGPHVDKKSREQFERRHHKRLIDILSSSSDTVDSLMQLELPSGVDVEIKV
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: TGO1_DROME
Sequence: MRLTNEKATMQPQLSDLALVLGLLICCLPTLTWAATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLISFKINSPIRVLSKSAGSNMQLWGVDINGRRGYANKDFIMEKKILVRDKDLLYEVPVVGPGSPVQSVETPVQSVETTVQPVLNASESTDDLATTTTSPLEIAVDSIVVEHDKLQDQQVPDPTAASKAQVQVIEGTELPLEAIAATTEGSIVPETAADPQEATNLDSTVVDTKEPQALNSEAIKLQEEPKAQQPATEAEKPPPLPQAINAELEDADDFDYGDDETDDDSQQGSQDNESIVEIANDNKSINESIELKPLSVAQLKKTDKVEDSKDETKEKHAEMEVSKQEDSSLPTETLNVTALEEQIDQKEFPKQVLDAAVELKSSDPLPVEEVTETVAEPPRTIVEDKINEEIVPVSAKIQAKPATVNPTEPIVAQSDAEIKAPSESVISSTTPAPVVEEAPQKADPVGLPPLFEKKNFENPNNYYKQLQEEQEKQRLVAEAEEQKRLQEEADQQKRLQEEAALNKRLLEEAEQQKRLQEEAEQQKRLQEEAELNKRLLEEAEKQKRLHEESEQLQRSSEEAEPQLSVQEANMQQLNDSVDSQSNEIVDNNNRQQPEQYQQHHHHTESAFNHPSTASHTTPTPDAESPYAAVQEETTEASQTDNHREGVGYVEPVALPATASPVSEVPIKEDAAGFGLFATIVDTVNNFIGKDPQSDPADSSDELHRILYPGRPEVPPSQRKAEDFAPADVDGYCARFQAKDEHCHRSISLDNFVEVMADKLVDHSQLLLCVVIAAISSLFFMFAYYCFCNSSQEGALLSKLNHLERSLLASHKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEKAKLQEQVGSLERDLDNAAEAGLELNKMLSEVLNGQNGDEAFMSTVDELQRQLNDQEKIIIEINNSLAEKSRENSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESELAKALEARNYEMQKLQNQIVELTVKWEREHGDLQTSLAKIEALEDCLKAVGKDAIHNVQELITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTMASGGGGVGGDPGVMEAIAANGTSVLGAELKTAPSPLPLPGSPLLNMPNPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGRMRSPPPSSRGDRDRERYSDYSDYDDYDDDEEDDRGMDRRRRHSGSWGRRHRGSYSHSPRTYRSLSPSDSRYNYNDTETDFSPPPSPPPVPSGRSATSRPYSEV
What is the function of this protein?
Required for protein secretion (PubMed:16452979, PubMed:23369713).  May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier (PubMed:16452979).  At basal transitional ER sites in follicle epithelial cells, mediates the exit of basal membrane protein such as vkg, LanB1 and Trol, from the endoplasmic reticulum (ER) to basal Golgi clusters (PubMed:23369713).
What are the official names of this protein?
Transport and Golgi organization protein 1.
What is the protein family that this protein belongs to?
Belongs to the MIA/OTOR family. Tango1 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network.
Protein: ISCS_VIBVU
Sequence: MKLPIYLDYSATCPVDPRVAEKMVQYMTMDGTFGNPASRSHRYGWQAEEAVDTAREQIAELLNADPREIVFTSGATESDNLAIKGAAHFYSKQGKHVITSKTEHKAVLDTCRQLEREGFEVTYLEPESNGLISLSKLEAAMRDDTVLVSIMHVNNEIGVIQDIEAIGELCRSRKIIFHVDAAQSAGKVAIDVQKLKVDLISLSAHKIYGPKGIGALYVRRKPRIRLEAQMHGGGHERGFRSGTLPTHQIVGMGEAFRIAKLDMEKDYQHALALRNRLLDGVKDMEAVTINGDLDQRVPHNLNISFAFVEGESLLMSLKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSFGRFTTEEEIDYAIEQIRVAVEKLRDMSPLWDMYKDGIDLNTVEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UFD3_CAEEL
Sequence: MADDGLGDVPMETESMPQYTISHVIEAHKSDTKALAVTQGGCLISGGRDETVKFWAKKGKQYTKTHAFEQPKGITVNSIAYAELADGWRLFVGRRDGTIAVFGPSQAEPYAIFNEHKQNVCCLHINEKATHMLSGSWDSNVIIWPITELNSSSFTFQTIVCPGHTLSVWALASFPDLPNTYLSASADKTIRMWFGDTTLSVFKGHTDVVRALVVLSSSHFLSAGNDGHIIHWDVASASILRKFATQAHEFIYSMTLSDSHILTTGEDGTLEFWAIDGGKDGNLAIVSEAVIQLPTTNTWDAKVLLNSDIAVAGSDGRIYIMTTDKNRKADDDILDAFDAEVVAKLTAKTERMKQEEHETVTIKVDIDDRPTQLNLKYKKGTDPGLCAQEFLSENNLPIHYLEEITRFIKDRIPEARAFDLKSGKKVIVDGKEYDYALGVNFGKGEPDKQMPFNVNESPQFAAQRFVERHQLPVSVIPSLAGMISQEMDKLSKGAASAQSGYEDPFTGPGRYVPQGSSNSGGHGADPFTGSGRYVPQASNSSGFDTGFSGDPLTGDGGYRASAPENTGSHAVPLSSLPQNKKKPRGPLVPVPDFYIIGLAGKGEKAIAKLKELNEKQDAFQLNPDQINGLEELFVLPTSSNYSSEVTQSAFEMSLQWPVEHLTPVLDFLRIALTHHSLNSYFCDRERGQELVGRLIAILVSDPADVALKVLVCRCIANAFSHPVGRNLFASTELSTLAPLVVRQVLNEKTVLQMSAATALANWSLALLQQSEQCEQLGPKEDLLRAILNGIESVDSFGYLGEDAIIRLLQALVTVMWGDASVIRLAKNRNIAQIAARLKDAVSNDSGKNIARDIVEMTYAV
What is the function of this protein?
Plays a role in protein ubiquitination, sorting and degradation through its association with cdc-48. 1 and/or cdc-48. 2.
What are the official names of this protein?
Ubiquitin fusion degradation protein 3 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PLAP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_VIBVU
Sequence: MPKMKNNKGAAKRFKKTAGGIKYKHATKRHILTKRTTKNKRQLRPNSLLPRCEVAAVARMLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PSBO_PEA
Sequence: MAASLQAAATLMQPTKLRSNTLQLKSNQSVSKAFGLEHYGAKVTCSLQSDFKELAHKCVEASKIAGFALATSALVVSGASAEGAPKRLTFDEIQSKTYLEVKGTGTANQCPTIDGGVDSFSFKPGKYNAKKLCLEPTSFTVKSEGVTKNTPLAFQNTKLMTRLTYTLDEIEGPFEVSADGSVKFEEKDGIDYAAVTVQLPGGERVPFLFTIKQLVASGKPDSFSGEFLVPSYRGSSFLDPKGRGASTGYDNAVALPAGGRGDEEELGKENNKSAASSKGKITLSVTQTKPETGEVIGVFESIQPSDTDLGAKAPKDVKIQGVWYAQLES
What is the function of this protein?
Stabilizes the manganese cluster which is the primary site of water splitting.
What are the official names of this protein?
Oxygen-evolving enhancer protein 1, chloroplastic, OEE1, 33 kDa subunit of oxygen evolving system of photosystem II, 33 kDa thylakoid membrane protein, OEC 33 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the PsbO family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: YQ53_CAEEL
Sequence: MADLLDKIMGSSSSNRIPKRDNRMNQDKDEPTSKRSAPMFSTPKSTTPIGRDSFATMDTMNVQMNMFPVDIKDMPHKIQRFQVDVIVCSSNGKQINANLGVLAAKGDVNSHNRRLAQYYIMRTVHDKLLVKFSGKSHHFLAYDCAATLYLPEGVYTGDDQEEVTLTIDDFPKEEWKFVSKLSRRKDDSYLVVLKPAGFVYTQGEVAQEEANRMELTRIIEIVTSQKLNNEDYLQFGNATFPRLSPPHSEPDAISEIRSGFAKVSRLSQNGGGKAFMTVDTKISPFYKDTSVIKFSSNKLSEMKGGGGGRGGYGRSDSRDSRGGYRGGRSDSRDFRGVYGNRGGNDRYRDESRGRRDMYDSRRDSGSSNGADYSPSDAAELEHAFGERGNTKRCIEEALKGLDVECTHLKGNLIRVSSIAENNAENTSFMMKDDKGEREVTVAEYFLLQYNIKLKYPRLPLVVSKRFKHESFFPMELLRIAPGQRIKVNKMSPTVQSAMTGRNASMPQHHVKLVQDILRDNLKLEQNKYMDAFGIKLMSTEPIQMTAKLLPPAQIKFKGQTYMPDMSRPAFRTQDKFVEPARIRKIGIVVFDNCIQMRQAEDFCDKLSNFCRDNGITVEKDSRDWSIRELNSSDSVAIQNLMKKWLDDRVDILVGIAREKKPDVHDILKYFEESIGLQTIQLCQQTVDKMMGGQGGRQTIDNVMRKFNLKCGGTNFFVEIPNAVRGKAVCSNNETLRKKLLEHVQFIGFEISHGASRTLFDRSRSQMDGEPSVVGVSYSLTNSTQLGGFTYLQTQKEYKLQKLDEFFPKCVRSYKEHSKTLPTRIVIYRVGAGEGNFNRVKEEVEEMRRTFDKIQPGYRPHLVVIIAQRASHARVFPSCISGNRATDQNIPSGTCVENVLTSYGYDEFILSSQTPLIGTVRPCKYTILVNDAKWSKNELMHLTYFRAFGHQVSYQPPSVPDVLYAAENLAKRGRNNYKIHQRYVNLQAVENRIIKDHSELINEDMREELAAAIVDEMSVAMNGMTIPKRNFWA
What are the official names of this protein?
Uncharacterized protein C16C10.3.
Protein: SCR8_ORBFA
Sequence: MAAKFHLCLLLIILGTITVQGARHPGKPHFFRRQPGSDCASINGRCVPPNERCPNGECHLQSCPGYQEKCCCPV
What is the function of this protein?
Induces neurotoxic symptoms on zebrafish (By similarity).  Has also been claimed to be implied in calcification, but tests on homolog proteins suggest that proteins of this family have a neurotoxic function and not a calcification function (PubMed:19283069).
What are the official names of this protein?
Small cysteine-rich protein 8, Mfav-SCRiP8, SCRiP8.
What is the protein family that this protein belongs to?
Belongs to the Cnidaria small cysteine-rich protein (SCRiP) family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: PSBH_SYNJB
Sequence: MAIRTRLGDLLRPLNSEYGKVAPGWGTTPLMAVFMALFAVFLLIILQIYNKSLLLEDINVSWESLSF
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: LACD_LISMO
Sequence: MVQITKGKFDGLQRLSNDKGVIAALAIDQRGSLKKMIQQAKGTENKKDVEDFKQLVSEELTPYASAILLDLEYGTPAIKARHEGSGLLTSYEKTGYDATTPGKLPDLIEDLSALRIKENGGDAVKILVYYDPDEPAEINEIKYAFLERIGAECRAVDIPFFLEPITYDATVTDSGSLEYAKLKPAKVKASIKEFSKPRYGVDVLKLEVPVNFKYVEGFAEGEVAYTQDEAARHFEECSDLSPLPFIYLSAGVTSEMFHKTIQFANQHNVQYSGVLCGRATWADGIEVYGKQGDDALREWLRTQGKENITSLDKLLDEGAVPWWTKYGSFEDVHVVEKQ
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase, D-tagatose-1,6-bisphosphate aldolase, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: FLGH_LEGPL
Sequence: MNRLNIAVSCLATALLFGCEALHPPAPGDNPDYAPTYPVTPDPKELRKVSGAIYSSETALPLFETPRARHPGDILTVFLIEKTDAQKNATTTQRKNDTTKITNKLFLGRPISLGSGYSMDFDLDNQRQFNGEGRSIQNNKLAGSISVTVAKVLANGNMVVQGEKWVRINQGNEFVRLSGIVRPQDIKADNTITSDRIANARISYGGTGQINNTNAQGWLSRILWGPLFPT
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.