PharMolix/UniProtQA huggingface dataset:
Protein: SUT1_SCHPO
Sequence: MSVDENQLENGQLLSSENEASSPFKESIPSRSSLYLIALTVSLLGVQLTWSVELGYGTPYLFSLGLRKEWTSIIWIAGPLTGILIQPIAGILSDRVNSRIGRRRPFMLCASLLGTFSLFLMGWAPDICLFIFSNEVLMKRVTIVLATISIYLLDVAVNVVMASTRSLIVDSVRSDQQHEANSWAGRMIGVGNVLGYLLGYLPLYRIFSFLNFTQLQVFCVLASISLVLTVTITTIFVSERRFPPVEHEKSVAGEIFEFFTTMRQSITALPFTLKRICFVQFFAYFGWFPFLFYITTYVGILYLRHAPKGHEEDWDMATRQGSFALLLFAIISLAANTALPLLLEDTEDDEEDESSDASNNEYNIQERNDLGNIRTGTNTPRLGNLSETTSFRSENEPSRRRLLPSSRSIMTTISSKVQIKGLTLPILWLSSHVLFGVCMLSTIFLQTSWQAQAMVAICGLSWACTLWIPYSLFSSEIGKLGLRESSGKMIGVHNVFISAPQVLSTIIATIVFIQSEGSHRDIADNSIAWVLRIGGISAFLAAYQCRHLLPINF
What is the function of this protein?
Responsible for the transport of maltose and sucrose into the cell, with the concomitant uptake of protons (symport system).
What are the official names of this protein?
General alpha-glucoside permease.
What is the protein family that this protein belongs to?
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL15_SULSY
Sequence: MRLHELKPNEGATHKKKRVGRGIGSGHGKTSTKGQKGQTSRSGDSKLPARFEGGQTPFIMRIPKRGFKNPSKIEYEIVNLKALENKFNENEEVNPQTLKEKGLVKKGECVKILGDGQLTKKLTVKAHAFSASAEEKIKSVGGIAEKITAETT
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: EXB16_ORYSJ
Sequence: MAAFSSSSSAPMLIRSVLFVSLLSAAFVFDSGEAGAAHRVVDPEWHPATATWYGSADGDGSDGGACGYGTLVDVVPMKTRVGAVSPVLFKGGEGCGACYKVRCLDASICSRRAVTVIVTDECPGGVCAFGRTHFDLSGAAFARLAVAGHGGQLQNRGEISVVYRRTACKYGGKNIAFHVNEGSTTFWLSLLVEFEDGDGDIGSMQLKQANSAQWQDMKHIWGATWSLTPGPLVGPFSVRLTTLTTRQTLSAQDVIPKNWTPKATYTSRLNFA
What is the function of this protein?
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans.  No enzymatic activity has been found.  May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
What are the official names of this protein?
Expansin-B16, Beta-expansin-16, OsEXPB16, OsaEXPb1.14.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin B subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: NDK_ANAMM
Sequence: MMFEKTLSILKPDVVERGIIGRVLSYIEAAGLRIVAQRMCALSHEQAEAFYAVHKARPFFPSLVGFMTSGPVVVQVLVGESAVKTYRDVMGATNPSEAAPGTIRGDLAESIDANCVHGSDSLENAEWEIKFFFKEHEIMSSMPNGK
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_BRASO
Sequence: MTAEQQAGQGATRCGFVALIGAPNVGKSTLVNALVGSKVTIVSRKVQTTRALIRGIVIEGQSQIILVDTPGIFSPKRRLDRAMVTTAWSGAHDADLVCVLLDAKKGLDDEAQAIIDKAASVAHEKILVVNKVDLVPREKLLALVAAANEKLAFARTFMISALSGDGVDDLRRALAEMVPPGPFHYPEDQMSDAPMRHLAAEITREKIYSHLHQELPYQSTVETDSWTERNDGSIRIEQTIFVERDSQRKIVLGKGGATIKSIGAQSRKEIAEITGVPVHLFLFVKVRENWGDDPDRYREMGLEFPRE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: WLS_PONAB
Sequence: MAGAIIENMGTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE
What is the function of this protein?
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism.  This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins.  Also plays an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
What are the official names of this protein?
Protein wntless homolog, Integral membrane protein GPR177, Protein evenness interrupted homolog, EVI.
What is the protein family that this protein belongs to?
Belongs to the wntless family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: ACKA_CRYNB
Sequence: MPDKTEYLLAINCGSSSIKGKLFAIPSFELLANLAVTNISSADERVKIRITWEEGKGKNSEEEADYGDKIRYASLVPILLDHLTNSTHVEKEEIKYVCHRVVHGGTHDRGIRVVKGHEEGLIEMDKLSEFAPLHNHRAVLAVKSCLDALPHHTSLLLFDTIFHQTIAPEVYTYALPPSDNELSMPLRKYGFHGLSYASIVRSLAEHLKKPSDQVNVVVAHLGSGSSSCCIKNGKSVDTSMGLTPLEGLLGGTRSGTIDPTAIFHHTKDAASDANVGDFTVSKAEIILNKNSGLKALAGTTNFGHIIQNLDPSKCSKEDHEKAKLTYAVFLDRLLNFVAQYLFKLLSEVPIESIDGLVFSGGIGEKGAELRRDVLKKLAWLGAEVDEEANNSNSGGTVKCITKEGSKLKGWVVETDEEGWMATMAKEEFGF
What are the official names of this protein?
Probable acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
Protein: RL24_DICTD
Sequence: MDIKKGDLVLVISGKDKGKRGRVISVLPSEEKVVVEGVNIVKKHTRPTAKMRQGGIIEKPAPLYRCKVMLICPHCNQPTRVKHTFLEDGRKVRVCSKCKEIIDRV
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: NU1M_BOSIN
Sequence: MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLSTLIITQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity).  Essential for the catalytic activity and assembly of complex I (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PLSX_STAA2
Sequence: MVKLAIDMMGGDNAPDIVLEAVQKAVEDFKNLEIMLFGDEKKYNLNHERIEFRHCSEKIEMEDEPVRAIKRKKDSSMVKMAEAVKSGEADGCVSAGNTGALMSVGLFIVGRIKGVARPALVVTLPTIDGKGFVFLDVGANADAKPEHLLQYAQLGDIYAQKIRGIDNPKISLLNIGTEPAKGNSLTKKSFELLNQDHSLNFVGNIEAKTLMDGDTDVVVTDGYTGNMVLKNLEGTAKSIGKMLKDTIMSSTKNKLAGAILKKDLAEFAKKMDYSEYGGSVLLGLEGTVVKAHGSSNAKAFYSAIRQAKIAGEQNIVQTMKETVGESNE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: MIAA_FERNB
Sequence: MNLKRIIISGPTGVGKTDLIVEISKNLPIEVISMDSRQIYKYMDIGTAKPDPYQLMLVKHHMIDIIEPNEYFNAFLYQKMAKEIEKEILLRGKIPIYVGGTGLYIDALVKGFFEGVPRDENIRKELSKLNEQEPGILRKMLEEFDPEAASRIHPQDMKRTIRALEVYLKTGKRISELQKQDKSDDFVLIVLNTDRNILYERINIRAEKMIEHGLIDEVKELIEKYDKTLDTFKTIGYREIIDYLDGIYGLETAIHLIKRNTRHYARRQLIYLRRFKNSLWFDPLHSETKEKIVEIISGVYNELSQKKE
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: NRDI_STAAU
Sequence: MKIIYFSFTGNVRRFIKRTELENTLEITAENCMEPVHEPFIIVTGTIGFGEVPEPVQSFLEVNHQYIRGVAASGNRNWGLNFAKAGRTISEEYNVPLLMKFELHGKNKDVIEFKNKVGNFNENHGREKVQSY
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: NER_BPD10
Sequence: MHMNKRTNRQDWHRADIVAELRKRNMSLAELGRSNHLSSSTLKNALDKRYPKAEKIIADALGMTPQDIWPSRY
What is the function of this protein?
Switches off the PcM promoter thereby blocking expression of the major repressor Repc (latency factor) and favoring transcription from the early promoter (Pe) and hence viral transposition and lytic development.  Negatively regulates the early promoter (Pe) thereby controlling its own expression and keeping the level of early genes expression independent of the viral genome copy number (By similarity).
What are the official names of this protein?
Negative regulator of transcription, Ner.
What is the protein family that this protein belongs to?
Belongs to the ner transcriptional regulatory family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: SEMG2_HYLLA
Sequence: MKSIILFVLSLLLILEKQAAVMGQKCGSKGQLPSGSSQFPRGQKGQHYSGQKDEQHTKSKGSFSIQHTYHVDVNDRDRTQKSQQYDLNAQHKMTKSKQHLGGSQELLNYKQEGRDHDKSKDHFHMIVIHHKGGQAHRGTQNPSQDQGNSPSGKGISSQYSNTNKRLWVHGLTKEQASASGAQKGRTQGGSQSSYVLQTEELVANKQQRETQNSPQNKGHYQNVVEMREEHSSKLQTSLHPAYQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLNQDQEHGQKTHKISYQSSRTEERQLNCGEKSVQKDVSKGGISIQTEEKIHGKSQNQVTIHSQGQEHGHKENKMSYQSSSTEERHLNCGEKGIHKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEHGHKENKMSYQSSSTEERRLNCGEKGIHKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEHGHKENKMSYQSSSTEERRLNYGGKSMQKDVSQSSTSFHTEKLVEGKSQIQTPNPNQDQWSVQNAKGKSDQSAGREQDLLSHEQKGRHQQESSEARNIVITEHEVAYDDHLTQQYNEDRNPVST
What is the function of this protein?
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
What are the official names of this protein?
Semenogelin-2, Semenogelin II, SGII.
What is the protein family that this protein belongs to?
Belongs to the semenogelin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NACB_PICGU
Sequence: MPVDPEKLAKLQQGAAKKVGGQRVKAKKVKSEQDDTKLMEALGKLKATKVNAVEEANFFKEDGKVLHFKRVGVQSAAQHNVCAFTGYPQEKDVTQLIPQILPQLGAENLEILRQLAEQIQAGKTPSMGGENAGADEDIPDLIEGQKFDEVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: SYS_ACISJ
Sequence: MLDILLLRKDLASAVARLETRKKPQAFLNVEAFQALESERKTIQMRTEELQSQRNQLSKQIGMLMGKGEKDAAEAAKAQVAAIKAELDGSATRLDQIQGELQTMLAAVPNLPHESVPVGSDESANVEVRRWSPDGQQPRSLGFTPKDHVDLGEPLGLDFDMGVKLSGSRFTVMKGGIARLHRALAQFMLDVQTQEHGYTECYVPYVVNADSLKGTGQLPKFEGDLFAAQKGGQDAEPVPDNAQLYLIPTSEVPLTNFVRDEVLAEAQLPLKLTAHTPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVHPDKSYEALEEMTRHAEAVLQKLGLPYRVMSLCTGDMGFGAAKTYDLEVWLPAQNTYREISSVSNCEAFQARRLQARFKNAQGKNELVHTLNGSGLAVGRTLVAVLENYQNEDGSVTIPEVLRPYMGGQATLSV
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED8B_XENLA
Sequence: MQREEKQLEACLDALISQVSDIKNSLVGFIHKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKNEKTPLLRNQVIIPLLLSPDRDEEIMRLTEGRVPVFSHEVVPDHLRTKPDPDVEELEKQISADATRLTSEAAQKQVQSMNKMCSNLLDKISKEERESELGSLRQNKQTFNPTDTNALVAAVAFGKGLSNRRPPGQGGPMAPGQTGASGMIPGAAGMQQVPMSLSQNQQQQQHMAGVSMSQGSQPGKMPSSIKTNIKSASMHPYQR
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 8-B, Mediator complex subunit 8-B.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS3_ECOL5
Sequence: MGQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEKPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PSBM_ANTAG
Sequence: MEVNILAFIATALFILIPTAFLLILYVQTASQGS
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ISPE_CLOPE
Sequence: MKMKAYAKINIALDAIGKREDNYHLLRMIMQTVDLYDVIDIEKSNDSNISISCNKHYVSTDERNLAYKAAVLFRDEFNIKDGVKINIKKNIPVAAGMAGGSTNAAAVLVIMNKLFNVNASLEVLKEIGLKIGADVPYCIEGGTALCEGIGEIITPLKPFENKILVVLKPNFGVSTKEVYTNLDINKIRKHVNIEGLIQAMENDDLDYVSKNMKNVLENVTLKKHTILKNIKEDMRKSGALGAMMSGSGPTVFAFFDDMLTAQRAFEFLKGKYKYSDVYITRTINSNNL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ATG1_SCLS1
Sequence: MASKTPSSSSSRRPRNVGVGSFTINEEIGKGSFATVYRGTHVPSGSLVAIKSVNLGRLNKKLKDNLYVEIEILKSLHHPHIVALMDCRESTSHIHLMMEYCELGDLSYFIKKRDKLADNPSLFDMIRKYPMPVDGGLNQVVVRHFFKQLSSAMEFLRDRDFVHRDVKPQNLLLIPSPDWMAKSKNGPEAMKASKESIVPMVGINSLPMLKLADFGFARSLPSTSLAETLCGSPLYMAPEILRYEKYDARADLWSIGTVLYEMMTGKPPFRAANHVELLRKIEQNEDEIRFPSKTVFSRDLKDIARRFLKKRPEDRITFPEYFAHPVVTGPIPGLVGEDLPKEIITPSRSPEASVARHPSLRERQRENPTPKPVETTYESLIARDIGEQAPRSPHIEANQPVEIPGHKSGRPGSRDRPSAISAATAPNVDTLPRQRDRTERHYAPIGRPVSRKPSYDEQANLPVQEEIRSSDSITEAEQDVRDAREYVLVEKKAVEVNAFADEMAASPRLAHANHIPKQPTRRHTSMGAPNSTSGAVAVPPSRAVQKAQGNTRPDTSSARNSYGSYGKTGSSPSTASAIAKALQGASVRVFGVSWSPTLIGKGPSPQQLYNPYPAYPTPNTGFIGDARPIDEDQRVVNVIEDSATRSDVVYGFAEVKYRQLIPLAPSMNHGLGGPNNEKVGDAMDEDDGLTVEAIVNLSEEALVLYVKSLSLLSKSMDIAGAWWLRKNRGGVISGGHTPGSDSSSAVQAGNRINGAVQWVRTRFNEVLEKAELVRLKLVEAQKRLPEDHPGHPSNHATASKIVGGSSTTDGVVLSSGITAEKLMYDRALEMSRTAAINELANEDLPGCEISYTTAIRMLEAVLENDEELIPRKRSPSLREDKEKCDGGEVNGINFGDRKDVLKVLQMIRTRLHVLKKKMAVIARHQSMPPPSSPRHSHSGGTTPTIANTPPH
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
What are the official names of this protein?
Serine/threonine-protein kinase ATG1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: MECA_STRP8
Sequence: MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEINKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVHYVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLMLDGAVEQLQKIELG
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: NSP4_ROTP5
Sequence: MDKLADLNYTLSVITLMNDTLHSIIQDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVIKYCMVTIINTLLKLAGYKEQVTTKDEIEQQMDRIIKEMRRQLEMIDKLTTREIEQVELLKRIHDKLAARSVDAIDMSKEFNQKNIRTLDEWESGKNPYEPSEVTASM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: RR8_GOSHI
Sequence: MGKDTIADIITSIRNADMNRKGTIQIGSTNITENIVKILLREGFIDNVRKHRERNKYFLVLTLRHRRNRKGPHRTILNLRRISRPGLRIYSNYQQIPRILGGMGIVILSTSRGIMTDREARLEGIGGEILCSIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y484_ACIBC
Sequence: MIHHIPNVLSKEQVQYFRNEMDKIEWVNGKVTAGTLSATVKRNQQLPEDHPLTHHLSNIILEALGTHPLFLSAAIPLDIIPPLFNRYENQESFGFHVDNSIRRIRGTNERLRTDLSCTLFLSEPEEYEGGDLVVEDTYGYHEVKLPAGDMILYPSTSLHEVTAITSGCRIASFFWVQSMVRDDAERHMLFNLDQTVQNLRMQLGDNHSEVIKLTNLYHNLMRKWAEL
What are the official names of this protein?
PKHD-type hydroxylase ACICU_00484.