PharMolix/UniProtQA huggingface dataset:
Protein: SECA_NEIM0
Sequence: MLTNIAKKIFGSRNDRLLKQYRKSVARINALEEQMQALSDADLQAKTAEFKQRLADGQTLDGILPEAFAVCREASRRTLGMRHFDVQLIGGMVLHDGKIAEMRTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLASRDAGIMEPLYNFLGLTVGVIISDMQPFDRQNAYAADITYGTNNEFGFDYLRDNMVTDQYDKVQRELNFAVVDEVDSILIDEARTPLIISGQADDNIQLYQIMNTVPPHLVRQETEEGEGDYWVDEKAHQVILSEAGHEHAEQILTQMGLLAENDSLYSAANIALMHHLMAALRAHSLFHKDQHYVIQDGEIVIVDEFTGRLMSGRRWSEGLHQAVEAKEGVEIKRENQTLASITFQNYFRLYTKLSGMTGTADTEAFEFQSIYNLETVIIPTNRPVQRKDFNDQIFRSAEEKFEAVVKDIEECHKRGQPVLVGTTSIENSELVSHLLQKAGLPHNVLNAKEHEREALIVAQAGKVGAITVATNMAGRGTDIVLGGNLKHQTDAIRADETLSDEEKQAQIAALENGWQAEHDKVMEAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSFEDPLLRLFALDRAAAILNRLAPERGVAIEHNLLTRQIEGAQRKVEGRNFDMRKQVLEYDDVANEQRKVIYSQRNEILTSKDISDLMQEIRSDVVSDLVDTYMPPDSMEEQWDIPTLENRLAAEFRLHEDIQSWLKADNAIDGQDIKERLIERIENEYAAKTELVGKQAMADFERNVMLQVIDNQWREHLAAMDYLRQGIHLRSYAQKNPKQEYKREAFTMFQDLWNGIKFHIASLLTSVQIEQNPVAVVEEQPIGNIQSIHSESPDMEELLGQSQTDLVTEAFNPDGTDFSPEALEARGQIVHRNDPCPCGSGLKYKQCHGKLA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ENKD1_HUMAN
Sequence: MCEGPSRISGPIPPDPTLCPDNYRRPTSAQGRLEGNALKLDLLTSDRALDTTAPRGPCIGPGAGEILERGQRGVGDVLLQLEGISLGPGASLKRKDPKDHEKENLRRIREIQKRFREQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEPGPASGTESAHFLRAHSRCGPGLPPPHVSSPQPTPPGPEAKEPGLGVDFIRHNARAAKRAPRRHSCSLQVLAQVLEQQRQAQEHYNATQKGHVPHYLLERRDLWRREAEARKQSQPDPAMPPGHTRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKIFSRPKVFVKMDD
What is the function of this protein?
Microtubule-binding protein which regulates microtubule organization and stability (PubMed:35197565, PubMed:35072334).  Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed:35197565).  This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity).  Required for the assembly of both primary and motile cilia (PubMed:35301795).  Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795).
What are the official names of this protein?
Enkurin domain-containing protein 1.
Protein: ETXA_STAAU
Sequence: MKKTAFTLLLFIALTLTTSPLVNGSEKSEEINEKDLRKKSELQGTALGNLKQIYYYNEKAKTENKESHDQFLQHTILFKGFFTDHSWYNDLLVDFDSKDIVDKYKGKKVDLYGAYYGYQCAGGTPNKTACMYGGVTLHDNNRLTEEKKVPINLWLDGKQNTVPLETVKTNKKNVTVQELDLQARRYLQEKYNLYNSDVFDGKVQRGLIVFHTSTEPSVNYDLFGAQGQYSNTLLRIYRDNKTINSENMHIDIYLYTS
What is the function of this protein?
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules (PubMed:2658055, PubMed:12467569).  In turn, waves of cellular activation, cytokine production, and migration into the lung tissue and airways occur via alphabeta T-cells (PubMed:23321986).  Causes also the intoxication staphylococcal food poisoning syndrome.  The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death (Probable).
What are the official names of this protein?
Enterotoxin type A, SEA.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NQRC_CHLPN
Sequence: MSKGSSKHTVRINQTWYIVSFILGLSLFAGVLLSTIYYVLSPIQEQAATFDRNKQMLLAAHILDFKGRFQIQEKKEWVPATFDKKTQLLEVATKKVSEVSYPELELYAERFVRPLLTDAQGKVFSFEEKNLNPIEFFEKYQESPPCQQSPLPFYVILENTSRTENMSGADVAKDLSTVQALIFPISGFGLWGPIHGYLGVKNDGDTVLGTAWYQQGETPGLGANITNPEWQEQFYGKKIFLQDSSGTTNFATTDLGLEVVKGSVRTTLGDSPKALSAIDGISGATLTCNGVTEAYVQSLACYRQLLINFSNLTHEKKTGE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit C, Na(+)-NQR subunit C, Na(+)-translocating NQR subunit C, NQR complex subunit C, NQR-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the NqrC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TRMD_STAEQ
Sequence: MKIDYLTLFPEMFEGVLNHSILKRAQDKGIINVNTINFRDYSINKHNQVDDYPFGGGQGMVLKPEPVFNAMEDINRNEHTRVILMCPQGRPFTQEIAQELSEAKHIVFICGHYEGYDERIRKHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNQASHQDDSFSDGLLEFPQYTRPREYKNMSVPEVLLSGNHAHIDQWRHEQKLIRTYEKRPDLLEQYPLTEKDREILETYKKKLKND
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLS5_ARATH
Sequence: MEEERDHNASESSLPSLSKQLESSTLGGSAVDVPVVDLSVSDEDFLVREVVKASEEWGVFQVVNHGIPTELMRQLQMVGTQFFELPDAEKETVAKEEDFEGYKKNYLGGINNWDEHLFHRLSPPSIINYKYWPKNPPQYREVTEEYTKHMKRLTEKILGWLSEGLGLQRETFTQSIGGDTAEYVLRVNFYPPTQDTELVIGAAAHSDMGAIALLIPNEVPGLQAFKDEQWLDLDYIDSAVVVIIGDQLMRMTNGRLKNVLHRAKSDKDKLRISWPVFVAPRADMSVGPLPEFTGDENPPKFETLIYNDYIDQKIRGWALEDLPVY
What are the official names of this protein?
Probable flavonol synthase 5.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: DHH_DANKE
Sequence: VMNMWPGVKLRVTEGWDEDGNHFEDSLHYEGRAVDITTSDRDRNKYGMLARLAVEAGF
What is the function of this protein?
Intercellular signal essential for a variety of patterning events during development.
What are the official names of this protein?
Desert hedgehog protein, DHH.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Cell membrane. Secreted, extracellular space. Note=Desert hedgehog protein N- product: Cell membrane; Lipid-anchor; Extracellular side. The N- terminal peptide remains associated with the cell surface. Desert hedgehog protein C-product: Secreted, extracellular space. The C- terminal peptide diffuses from the cell.
Protein: CAN8_RAT
Sequence: MAALAAGVSKQRAVAEGLGSNQNAVKYLGQDFETLRKQCLNSGVLFKDPEFPACPSALGYKDLGPGSPDTQGIVWKRPTELCPNPQFIVGGATRTDIRQGGLGDCWLLAAIASLTLNEKLLYRVLPRDQSFQKDYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEEGNEFWSALLEKAYAKLNGSYEALVGGSTIEGFEDFTGGISEFYDLKKPPENLYYIIQKALRKGSLLGCSIDVSTAAEAEATTRQKLVKGHAYSVTGVEEVNFHGRPEKLIRLRNPWGEVEWSGAWSDNAPEWNYIDPRRKEELDKKAEDGEFWMSFSDFLKQYSRLEICNLSPDSLSSEEIHKWNLVLFNGRWTRGSTAGGCLNYPGTYWTNPQFKIHLDEVDEDQEEGTSEPCCTVLLGLMQKNRRRQKRIGQGMLSIGYAVYQIPKELESHTDAHLGRDFFLGRQPSTCSSTYMNLREVSSRVRLPPGQYLVVPSTFEPFKDGDFCLRVFSEKKAKALEIGDTVSGHPHEPHPRDMDEEDEHVRSLFEEFVGKDSEISANQLKRVLNEVLSKRTDMKFDGFNINTCREMISLLDSDGTGSLGPMEFKTLWLKIRTYLEIFQEMDHNHVGTIEAHEMRTALKKAGFTLNNQVQQTIAMRYACSKLGVDFNGFVACMIRLETLFKLFRLLDKDQNGIVQLSLAEWLCCVLV
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease.  Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein.  Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
What are the official names of this protein?
Calpain-8, Calpain large subunit 4, New calpain 2, nCL-2, Stomach-specific M-type calpain.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus.
Protein: AGI2_WHEAT
Sequence: MRKMMSTMALTLGAAVFLAFAAATAQAQRCGEQGSNMECPNNLCCSQYGYCGMGGDYCGKGCQNGACWTSKRCGSQAGGATCPNNHCCSQYGHCGFGAEYCGAGCQGGPCRADIKCGSQSGGKLCPNNLCCSQWGFCGLGSEFCGGGCQSGACSTDKPCGKDAGGRVCTNNYCCSKWGSCGIGPGYCGAGCQSGGCDAVFAGAITANSTLLAE
What is the function of this protein?
N-acetyl-D-glucosamine / N-acetyl-D-neuraminic acid binding lectin.
What are the official names of this protein?
Agglutinin isolectin 2, Isolectin D, WGA2.
Protein: Y082_ATV
Sequence: MFAFDNKAQENEQQDEDPGTRTKEEEKNVTSIYKNINFLKKIFDQSKKEGIEYLIVLGKNFADYYRKGVKGAENLAIHGGDG
What are the official names of this protein?
Uncharacterized protein ORF82.
Protein: UGT9_CATRO
Sequence: MGTIDIITSPTPIHILAFPFPAKGHINPLLHLCNRLASKGFKITLITTVSTLKSVKTSKANGIDIESIPDGIPQEQNHQIITVMEMNMELYFKQFKASAIENTTKLIQKLKTKNPPPKVLIYDSSMPWILEVAHEQGLLGASFFTQPCSVSAIYYHMLQGTIKLPLENSENGMVSLPYLPLLEKKDLPGVQQFEDNSEALAELLADQFSNIDDVDYVLFNTFDALEIEVVNWMGSKWPILTVGPTAPTSMFLLDKKQKNYEDGRSINYLFETNTEVCMKWLDQREIDTVIYVSFGSLASLTEEQMEQVSQALIRSNCYFLWVVREEEENKLPKDFKETTSKKKGLVINWCPQLDVLAHKSVACFMTHCGWNSTLEALCSGVPMICMPQWADQTTNAKLIEHVWKIGVGVNKSDENGIVKREDIEDCIRQVIESERGKELKRNAIKWKELAKEAVSEGGSSYNNIQEFSSSLLFN
What are the official names of this protein?
UDP glycosyltransferase 9, CrUGT9.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: SYH_PARP8
Sequence: MTEQKKRLEKLSGVKGMNDILPQDAGLWEFFETTVKSMLRSYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFTDALNGENLTMRPENTAAVVRASIEHNMLYDGPKRLWYIGPMFRHERPQRGRYRQFHQVGVEALGFAGPDTDAEIILMCQRLWDDLGLTGIKLEINSLGLAEERAKHRVELIAYLEKHMDVLDEDAKRRLYTNPLRVLDTKNPALQAVAQNAPKLIDFLGDESRAHFEGLQRILKANNIPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGIERILELLKEENLVPENEGCDVYVAHQGEAARDQAFIVAERLRDTGLDVILHCSPDGQASSFKSQMKRADASGAAFAVILGEDEIANGTAGVKALRDSSQSNGKSEQQTVPLEDLTEYLINAMVASTEDGDD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_PARXL
Sequence: MQLLTIGINHHTAPVALRERVAFPLEQIKPALDTFKSIWLGPSARTAPEAAILSTCNRTELYCATDDQAAREAAIQWLSRYHNLPIGELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQIVGQMKDAVRTASEAGALGTYLNQLFQRTFAVAKEVRSTTEIGAQSVSMAAAAVRLAQRIFDKVANQRVLFIGAGEMIELCATHFAAQQPKELVVANRTAERGTRLAERFNGRAIPLSELPSRMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGQLEDVFLYTVDDLGAIVREGNASRQAAVAQAEAIIETRVQNFMQWLDARSIVPVIRHMHTQADVLRRAEVERAQKMLARGDDPAAVLEALSQALTNKLIHGPTHALNRASSENRDTLIELMSGFYKHSGSTER
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: CH60_HELAH
Sequence: MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPKGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGAQLVKEVASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAAEAIINELKKSSKKVGGKEEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKMTAQLDNAYILLTDKKISSMKDILPLLEKTMKEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGFGDRRKEMLKDIAVLTGGQVISEELGLTLENAEVEFLGKAGRIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQIASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIRAAQKVHLHLNGDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVQKHEGHFGFNASNGEYVDMFKEGIIDPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKATPAMPDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_METMP
Sequence: MSEDINNNLNNSDNSNGSNEKIIVGLDEAGRGPVLGPMVIASVKIDEKNLYKLNDLELKDSKQLSKKKREELYIIINEMCDVEKIVIDPETIDKQMEIINLNKIELSAFSKLSNHFIRENDNISIYIDACSSSEQSFSNQFKAKLINKNVEIIAEHKADENYKIVSAASIIAKVTRDRVIEEYKETFGEIGSGYPSDPKTKKFLKNYVYENRTLPKIARKSWATSKNLLKEIEESKIFQWVK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_SYNY3
Sequence: MNNAKVRIYDLSKELNLENRDILDICERLNVAAKSHSSTISESDAERIKAAAEKFTPQQPKKPRVASRPESKEDKSDPKQQKILAIHHKQEKSGGPSPARPTPPPRPKLQAPKAPTPPQPPVAKASAPKIQKQEEPAQEAPKSVAPPTQPLAPPPVPSLQSPPSKPAPPTPPAKKAAPAPRLAGPPGRTASPNKTAVPAPAKPKVNRPEIVSLKDNRGQARSPGDREEKVAIAAPEPPKPKVELRRPKPPRPEEDENLPELLEFPPLSRGKGVDGDNDADDGDLLSTEKPKPKLKRPTPPRLGKPDQWEDDEDEKANKAKAANKGKRRPKMDDDDDDLDIDGDNGPKPTLVSLSIARPPKPKSLAAKPSTPTVAKVKKPTLKSEAGSSAGGSSRSRGDRRDRKEVVQKPEVIMLDRSLTVRDLADLLKISETDIIKRLFLKGVAVQITQTLDEETARMVAESFEVAVETPERVAAAAKTTEMLDEADLDNLVRRPPVVTIMGHVDHGKTTLLDSIRKTKVAQGEAGGITQHIGAYHVEVEHNDKTEQIVFLDTPGHEAFTAMRARGAKVTDIAILVVAADDGVQPQTKEAISHAKAAGVPLIVAINKVDKPEANPDRIKQELSELGLLAEEWGGDTIMVPVSALNGDNLDGLLEMILLVSEVEELVANPNRQAKGTVIEANLDRTRGPVATLLIQNGTLRVGDAIVVGAVYGKIRAMIDDRGDKVEEASPSFAVEILGLGDVPAAGDEFEVFTNEKDARLQAEARAMEDRQTRLQQAMSSRKVTLSSISAQAQEGELKELNIILKADVQGSLGAILGSLEQLPQGEVQIRVLLASPGEVTETDVDLAAASGAIIIGFNTTLASGARQAADQEGVDIREYDIIYKLLDDIQGAMEGLLDPEEIESSLGTAEVRAVFPVGRGNIAGCYVQSGKIIRNRNLRVRRGDQVLFEGNIDSLKRIKEDVREVNAGYECGIGCSKFNDWKEGDIIEAYEMTMKRRTLAT
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFSA_NOSS1
Sequence: MTDWLYRYPPLYTGILLKRYKRFFADVQLTSGEVVTAHCPNTGPMTGVSTLGSAVQLSKSANPKRKLAYTLELIQVHDNEPTWVGVNTALPNQIVKLALAKYLFPELGNYSYIKSEVVYGVDKKSRVDFFLTGSDTERPIYLEVKNTTWTKGTLALFPDTETTRGQKHLRELTALLPQMRSVMLYFINRGDCTEFAPGDSTDPIYGKLLREAIALGLEVLPCRFDVTPEGIRYLGLAKLVI
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: RS19_THESM
Sequence: MARKKEFKYRGYTFEELINMSLEDLSKLLPSRQRRSLKRGLTPEQKKLLRKIRLAKKGKYKKPIRTHSRDMVILPEMVGMMIYVHNGKEFVPVQIREEMIGHYIGEFALTRKRVQHGSPGVGATRSSMFVAIK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: MIAB_AERS4
Sequence: MSKKLHIKTWGCQMNEYDSSKMADLLDASNGYTLTEEPEEADVLLLNTCSIREKAQEKVFHQLGRWKKLKANKPGLVIGVGGCVASQEGENIRSRAPYVDIVFGPQTLHRLPAMIKQVQEGRGAQVDIAFPEIEKFDSLPEPRAEGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPMDDVLYEIAQLAEQGVREVNLLGQNVNAYRGPTFDGSICSFAELLRLVAAIDGIDRIRYTTSHPIEFTDDIIEVYKDTPEVVSFLHLPVQSGSDRILTMMKRPHTVLEYKSKIRRLRAARPDITISSDFIVGFPNETDEDFEATMKLIEEINFDMSFSFIYSPRPGTPAADMPDDVDMEVKKVRLARLQHVINNQSMQIGRAMLGSTQRILVEGPSRLDPMQLCGRTENNRVVNFEGAHTLIGGFADVEITEVRPNSLRGRFIRGEDEMNLRIATAPREILARRPDNVPDALGVAAFTPH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRNIP_HUMAN
Sequence: MASLQRSRVLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAYGEGSGADCRRHVQKLNLLQGQVSELPLRSLEETVSASEEENVGHQQAGNVKQQEKSQPSESRWLKYLEKDSQELELEGTGVCFSKQPSSKMEEPGPRFSQDLPRKRKWSRSTVQPPCSRGVQDSGGSEVAWGPQKGQAGLTWKVKQGSSPCLQENSADCSAGELRGPGKELWSPIQQVTATSSKWAQFVLPPRKSSHVDSEQPRSLQRDPRPAGPAQAKQGTPRAQASREGLSRPTAAVQLPRATHPVTSGSERPCGKTSWDARTPWAEGGPLVLEAQNPRPTRLCDLFITGEDFDDDV
What is the function of this protein?
Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553).  Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).
What are the official names of this protein?
MRN complex-interacting protein, MRN-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the MRNIP family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage (PubMed:27568553). Phosphorylation on Ser-115 induces its nuclear localization and promotes genome stability (PubMed:27568553).
Protein: SUFS_YERPY
Sequence: MNFPIERVRADFPLLSRQVNGQPLVYLDSAASAQKPQAVIDKELHFYRDGYAAVHRGIHSLSAEATQQMEAVRTQVADFIHAASAEEIIFVRGTTEAINLVANSYGRHFLAAGDSIIITEMEHHANIVPWQMLAQDLGVEIRVWPLTATGELEITALAALIDDTTRLLAVTQVSNVLGTVNPIKDIVAQAKAAGLVVLVDGAQAVMHQPVDVQALGCDFYVFSGHKLYGPSGIGILYGKSALLQQMPPWEGGGAMIKTVSLTQGTTFADAPWRFEAGSPNTAGIMGLGAAIDYVTELGLLPIQQYEQSLMHYALAQLSQIKSLTLYGPTERAGVIAFNLGQHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYQVPSMCRASLALYNTREDVDRLVAGLQRIEKLLG
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo.
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LECA_DIOLA
Sequence: MGISKKSQLVPLLAFITMFLMVVSRVSSSIADANSLHFSFSQFSQNPKDLILQGDATTDSDGNLQLTRVSSDGSPQGSSVGRALFYAPVHIWEKSAVVASFDATFTFLIKSPDRDPADGITFFIANTDTSIPSGSGGRLLGLFPDANIIKNSTNLDFNAAYNADTIVAVELDSYPNTDIGDPSYPHIGIDIKSIRSKSTARWNMQTGKVGTAHISYNSVAKRLSAVVSYSGTSSTTVSYDVDLNNVLPEWVRVGLSATTGLYKETNTILSWSFTSKLKTNQLQDLRIASVV
What is the function of this protein?
D-mannose-binding lectin that also binds alpha-methyl-D-mannoside with even higher affinity (PubMed:24008245).  Has hemagglutinating activity against rabbit erythrocytes (PubMed:24008245).  Shows toxicity against the brine shrimp A. nauplii (PubMed:24008245).  Induces reversible paw edema and hypernociceptivity in rats (PubMed:28196677).
What are the official names of this protein?
Lectin, DlyL.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: ALR_STRP1
Sequence: MISSFHRPTVARVNLQAIKENVASVQKHIPLGVKTYAVVKADAYGHGAVQVSKALLPQVDGYCVSNLDEALQLRQAGIDKEILILGVLLPNELELAVANAITVTIASLDWIALARLEKKECQGLKVHVKVDSGMGRIGLRSSKEVNLLIDSLKELGADVEGIFTHFATADEADDTKFNQQLQFFKKLIAGLEDKPRLVHASNSATSIWHSDTIFNAVRLGIVSYGLNPSGSDLSLPFPLQEALSLESSLVHVKMISAGDTVGYGATYTAKKSEYVGTVPIGYADGWTRNMQGFSVLVDGQFCEIIGRVSMDQLTIRLPKAYPLGTKVTLIGSNQQKNISTTDIANYRNTINYEVLCLLSDRIPRIY
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: HIS3_SPHAL
Sequence: MDEQRDTTDRFLPRFDAAGLVTAIVVDADTQALLMVAHMNADAIEATRATGQAHFWSRSRSALWRKGETSGNGLTLVEMRVDCDQDALLLRVKPAGPACHTGRRSCFYRRVEADGGLTFLADDAQG
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_LEPBA
Sequence: MEKEKVSLADAKEHGLTETEFVEIQKILGRIPNSTELGIFSAMWSEHCSYKNSILKLKTLPTKSDKLLAGAGEENAGAMDIGDGLAVVFKIESHNHPTAVEPYQGAATGVGGIMRDIFTMGARPITSLNSLRFGDPKEPRNKYLLTRAVKGIGDYGNSLGIAVGGGELFLHPTFTKNPLVNAMTVGIAKHDEMASASTKGKVGNKVYIVGATTGRDGIHGASFASKDLTKESEEKRSAVQVGDPFMEKLLMEASLEAIQKKLLVGIQDMGAAGISCATSEMSAKGKTGMDVDLDKVPLREADMNAYEIMLSESQERMLVIPEVGKEGELVSIFHKWGLNAVEIGTVTADGILRIRKNGTLKAEIPAESLVLGGGAPRYVREEKRPTYLDEVVKFDPNKIPDLKPDTVPQTLNSLLSSLNISSRRPLYEQYDTEVGLVKVVEPGEDGGLVRIPGTKKGIAVATDCNSRYTYLNPYEGAQIAVCESARNVAATGAEPYGVTNNLNFGNPYIPENYYVFSECVRGLGDACRFLGLPVTGGNVSFYNESPEGPVFPTPTIGMVGVIDDVAKGLRTYPRTKEDVKYALVGNFQPTISASEYLYRSQGLDTGAIPNISLEKEKQTMDALIECRKNGLLTSAKDLSLGGLLVALAKIVIAGKKGVEVNLNELQTKVPRLDALCFGETGASFIVSFLPNDETKVRESFTSKGLSVYTLGSSSAKASLSVKGDGFHWEWTTKSLEVEFESGLKSYFE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_STRMU
Sequence: MKITVPATSANIGPGFDSVGVALSKYLSIEVLEEAASWHISHDLGDIPSDEHNLLLVTALKVAPDLRPHRLRMVSDIPLARGLGSSSSVIVAGIELANQLADLNLTDSEKLDIATEIEGHPDNVAPALFGNLVISSYINQKVNYVVADFPKSSFIAFIPNYELKTSDSRDVLPTDLTYKEAVAASSIANVAIAGLLTGDLKTAGEAIMNDRFHERFRQSLVREFAQIKEIGKRNGAYASYLSGAGPTVIVLTDQDKADQIKADIDALELSGSTHLLRIDAKGVRVEKN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.