PharMolix/UniProtQA huggingface dataset:
Protein: SYI2_BACCR
Sequence: MEKVDVKESAVGREMRIRKQWNEQNIFEQSIQNREGAQSFVFYEGPPTANGLPHVGHALGRTIKDLVARYKTMAGYKVLRKAGWDTHGLPVELGVEKQLGISGKHEIEEYGIEPFIQKCKESVFTYEKQWREFTESIGYWVDMDDPYVTLKNPYIESVWHILGTIHEKGLLYKGHRVSPYCPSCQTSLSSHEVAQGYKTVKDLSATVKFKVKDSENEYFLGWTTTPWTLPANVALAVHPNMEYVKAKQESHVYIVAKERVQEVLKENYEVLSVHKGEELLNTSYTAPFPMKEVTNGYRVIAADFVTGDSGTGLVHIAPAYGEDDYRVVQSEGLSFLHVVDEKGEYTEAVPFLKGKFVKDCDVDIVRYLAKEGLLYHKEKYEHSYPHCWRCDSPLLYYAGESWLIRTTAIKDTFLQNNDSVTWYPDHMKHGRFGKFLENMVDWNISRNRYWGTPLNVWECESCDHQFAPKSIAELRKHSTKETPEDLELHKPYVDEVQVCCGKCGGTMNRTPEVIDVWFDSGSMPFAQYHYPFENKELFEEQFPADVIAEGIDQTRGWFYSLLAVSALYTGKVPYKRVLSLGHVLDEEGQKMSKSKGNALDPVDLVDKFGADALRWALLVDSAPWNAKRFSERTVLEAKSKFVDTLVNVYSFYVLYANLDEYNPKETYDVKLTKLDEWVLSRLHSTTKKVRTALDDYQFTNAAREIAALVDEVSNWYVRRSRNRFWESGMNAEKAAAYETLHEVLVTISKLIAPFTPFVAEDIHLNLEGSSVHLADYPVVNESLLQPKLEAEMDAVLQVVELGRSNRNQHSLKVKQPLAELVLLEHNENDMDWESYRDIVMDELNVKAFHVELDETKYTSYQLKLNFKTAGPKFGKNVNAVNGWLKQLSQEEVQNFVSTGRAVYEATPEGEVVVTGEDVLVEKVAKSGFSNTTNGQYTVMLDTNVTEELLQEGVAREFIRAVQEYRKQLNLPVNLRVDIILDTEEELQRTLTNHKDLLEENLLVKQFTFGHLTNEDDELSLGETKLRIKLSAAN
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase 2, Isoleucyl-tRNA synthetase 2, IleRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSN_SHIB3
Sequence: MNTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLVDYSEETFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESMSWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVESNVARIVTFDGDREEAFAGEAITLVLTDEIDISRGDLLLAADEALPAVQSASVDVVWMAEQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLTQREVENLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDRLSNVTVGAGMVHEPKNEAAVASSEFSAFELELNALVRRHFPHWGARDLLGDK
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: CQ10A_HUMAN
Sequence: MAWAGSRRVPAGTRAAAERCCRLSLSPGAQPAPPPGPLPPPRPMRFLTSCSLLLPRAAQILAAEAGLPSSRSFMGFAAPFTNKRKAYSERRIMGYSMQEMYEVVSNVQEYREFVPWCKKSLVVSSRKGHLKAQLEVGFPPVMERYTSAVSMVKPHMVKAVCTDGKLFNHLETIWRFSPGIPAYPRTCTVDFSISFEFRSLLHSQLATMFFDEVVKQNVAAFERRAATKFGPETAIPRELMFHEVHQT
What is the function of this protein?
Required for the function of coenzyme Q in the respiratory chain.  May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).
What are the official names of this protein?
Coenzyme Q-binding protein COQ10 homolog A, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COQ10 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: FPG_AROAE
Sequence: MPELPEVEITCRGIRPLVAGRTLTALEVRNPRLRQPVPADLAQTLVGERLQGVRRRAKYLLLDFPHGSVLVHLGMSGSLRVVSADEPAGVHDHVDLVFGAEALRLRDPRRFGLVLWHAGDGLSHPLLAALGREPLERGFTGAWLHEATRGVRLSIKQTLMDAHRVVGVGNIYASESLFRARIHPLAPAGAIGPQRLARLVASVRETLLAAIDAGGSTLRDFVGGDGRAGYFQQQYFVYGREGLACRVCATPVRRVVIGQRSTFFCPRCQRR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RFX5_MOUSE
Sequence: MAEDKPDAKSPKTGARPQGGADAGEPTTLLQRLRGTISKAVQNKVEGILQEVQKFSDNDKLYLYLQLPSGPSVGEKSSEPSLLSNEEYMYAYRWIRNHLEEHMDTCLPKQSVYDAYRKYCESLACCRPLSTANFGKIIREIFPDIKARRLGGRGQSKYCYSGIRRKTLVSMPPLPGLDLKGSESPEMGPEVSPAPRDELVEAACALTCDWAERILKRSFSSIVQVARYLLQQHLISARSAHAHVLKAGGLAEEDERAPRERSLCKSKNVVESLEGGGPKKPERPAQPPKEQEARAGTDLPGRAERKKSVIDSSVPAASKPQVNALVARLPVLLPRAPRSLITPISGTLKVATLPLPTRVGGPQTAVPIINMILPPVPTLSGAGPGPGPGLGPRFGPGPGLGPGPGPGLGAGLGPGLGPGLGAGPGPGLGAGLGAGLGLGPGRVPPRAPILPRGAENREVGISSDPRPHDKGIKRTAEVPLSEASGQDPPVKEMKHETQDTTVSEAKRKRGRPRKKPGGSGERNATPEKSAAIVNSPRSPRLLWETWGSKRENNFIGRPEGPGPGGEAERETVLVQGQQDGAVSKGERSLSSQEAKEAEDKIPPVTSKVSVIKGRIQKEALQLVKGEADAATQGNKGLKGRVLQSSLTPEHKDPKATPP
What is the function of this protein?
Activates transcription from class II MHC promoters.  Recognizes X-boxes.  Mediates cooperative binding between RFX and NF-Y.  RFX binds the X1 box of MHC-II promoters.
What are the official names of this protein?
DNA-binding protein Rfx5, Regulatory factor X 5.
What is the protein family that this protein belongs to?
Belongs to the RFX family.
Protein: G6PI_LACLM
Sequence: MAHIKFDYSKLTPFVAENELDEIQWQIDGAAKLLHEGKGAGSDYIGWLDLPEDYDKEEFARIQKAAKKIQSDSEVLIVIGIGGSYLGARAAIDFLSNSFVNLQTAEERKAPRILYAGNSISSSYLADLVDYVADKDFSVNVISKSGTTTEPAIAFRVFEEMLVKKYGREEANKRIYATTDKEKGAVKVNADANNWETFVVPDSVGGRFSVLTAVGLLPIAASGADITALMEGANAARKEYTSTNVHENDAYAYAALRNILYRKGKFSEILINYEPSLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQWIQEGTRTVFETAIRIEKPRKNINIPELDADLDGLGYLQGKDVDFVNKKAADGVLLAHTDGNVPNMIVTLPEQDEFTLGYAIYFFELAIGVSGYLNGINPFNQPGVEAYKKNMFALLGKPGFEELSKELNDRL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3659_MYCTO
Sequence: MLGDTEVLANLRVLQTELTGAGILEPLLSADGTTDVLVTAPDSVWVDDGNGLRRSQIRFADESAVRRLAQRLALAAGRRLDDAQPWVDGQLTGIGVGGFAVRLHAVLPPVATQGTCLSLRVLRPATQDLAALAAAGAIDPAAAALVADIVTARLAFLVCGGTGAGKTTLLAAMLGAVSPDERIVCVEDAAELAPRHPHLVKLVARRANVEGIGEVTVRQLVRQALRMRPDRIVVGEVRGAEVVDLLAALNTGHEGGAGTVHANNPGEVPARMEALGALGGLDRAALHSQLAAAVQVLLHVARDRAGRRRLAEIAVLRQAEGRVQAVTVWHADRGMSDDAAALHDLLRSRASA
What are the official names of this protein?
Putative conjugal transfer protein MT3759.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMC_GLOVI
Sequence: MRQPADGWREQALAEARVHDIDAAEIDYLIEAVTGLDRLRVRLGGPQALEAHREKLAALWRRRIEEAMPLQYLLGTAHWRDLQLQVNPAVLIPRPESEALVDVAVDFCRSCAGARVVDLGTGSGAIAVAVARALPGATVWAVDASEAALVVAGANIERYGLSEQVHLLRGNWFVPLPTQPFDAVLSNPPYIPSAEIAALMPEVRLHEPLSALDGGSDGLDAVRQIIADAARHLRPGGILALEVMAGQGPTVVQLLARDSRYGCIRTVRDWAGIERIVVTYAWARGS
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: RUVA_FRATO
Sequence: MISFIKGVLIEKDPTALLIDVNGIGYEVFVPMTTFYTLGDIDSQVSLYTHFVVREDAQQLYGFKSKVDKKVFQELIKVNGIGARTAIAILSGMDSKTLLHCIENKDYALLATVPGIGKKTAERLVVEIYDKLLKMANEIYAQTSGTTTTSQDSQAQQAPTSVVLANSIFNESVDALLALGYKQKDAEKMARSAMGDATTAAEVIRKALQGSIKSKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: WDR1_HUMAN
Sequence: MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
What is the function of this protein?
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004).  Enhances cofilin-mediated actin severing (By similarity).  Involved in cytokinesis.  Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608).  Involved in myocardium sarcomere organization.  Required for cardiomyocyte growth and maintenance (By similarity).  Involved in megakaryocyte maturation and platelet shedding.  Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF.  Involved in the generation/maintenance of cortical tension (By similarity).  Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).
What are the official names of this protein?
WD repeat-containing protein 1, Actin-interacting protein 1, AIP1, NORI-1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat AIP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, podosome. Cell junction.
Protein: MSC6_KLULA
Sequence: MLSVRISARQCSVRGLATQANNVSQPAKDNATNGSDAATEKKGTARYQRIQPSVALNSLKTKLSNDFQKQQPAQKIYSQFQSDLQQLISEQQVNPRHFVNSSICNSVLAKLILQSKSELDGQSIGESASIPPTPFEILETYLKYNLARHQHFIIVLKQFLIDLQPKEAINLWISFLEHAKQMPLNNTGTSQVQALTSIAYLMLSKESNSAPDVNVLTQLLNITPSKVPFLAIEQEIKSLGLTATTKDELLKSFDDLLLQWFTADKDAFINEFLKNSNDLKLITYLWKQYLKLATKDFTTSNQEIPGAFMIKLAQLDRSLDAVKIMTQLKEASADFKPSVSLYNSLLQTVAYIPAFGKEAQSIKLNRIQAIWNSYIKSSGNITVASYKAMLEALIIAGHFKTVESFWTLDVPDDVKANSEISDIYLKNFFASVKKVHFSQLKSKIPSKVHNLELANTILLAMVHSDASVGDIDSFYSHTFQSTEGIKPNDKTLAIKLRANLAAFGDSKNESILGTIGLSANSPTATLVIEEFLKICENEESATALLKALNIDNKSNDSAKKVSNFLDYYLQHGNWEYAEELFKKYLTDNVKSPSSVNYRLFNSMFKGFSELSITRNDTGFVSKQQVYWELCQRIHNRIFNECVISTLKSVSALSRRNAEFSENELDFINNTVLPYLVKLKIENSFKLQNPKYLQNMKSNDKIHIPKELL
What is the function of this protein?
May be involved in the control of meiotic sister-chromatid recombination.
What are the official names of this protein?
Meiotic sister-chromatid recombination protein 6, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y6440_STRCO
Sequence: MLLLISPDGVDEALDCAKAAEHLDIVDVKKPDEGSLGANYPWVIREIRAAVPADKPVSATVGDVPYKPGTVAQAALGAAVSGATYIKVGLYGCATPEQAVEVMRGVVRAVKDHRADAFVVASGYADAHRIGCVNPLSLPDIARRSGSDAAMLDTAIKDGTRLFDHVPPDVCAEFVRRAHDCGLLAALAGSVRSGDLGELARIQTDIVGVRGAVCEGGDRTTGRIRPHLVAAFRAEMDRHVREHAAAAAQS
What is the function of this protein?
Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
What are the official names of this protein?
Putative (5-formylfuran-3-yl)methyl phosphate synthase, 4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase, 4-HFC-P synthase.
What is the protein family that this protein belongs to?
Belongs to the MfnB family.
Protein: PUR9_HAEIN
Sequence: MADRPIRQALLSVSDKTGIVEFAQGLVKRGVKLLSTGGTAKLLAQNALPVIEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGTDDAIMQQHGIEGIDMVVVNLYPFAATVAKPDCTLADAVENIDIGGPTMVRSAAKNHKDVAIVVNNHDFNAILAEMDQHQNSLTFETRFDLAIKAFEHTAQYDSMIANYFGQLVKPYHIAEEEEANAKCGQFPRTLNLNFVRKQAMRYGENSHQNAAFYVDLNVKEASVATANQLQGKALSYNNIADTDAALECVKEFDDPACVIVKHANPCGVALGKDILDAYNRAYQTDPTSAFGGIIAFNRELDEKTANEIVERQFVEVIIAPKVSAEAQEVMKRKKNVRLLECGEWTSRSERLDFKRVNGGLLVQDADLGMVGVDDLKVVSKRQPTEQELKDLLFCWKVAKFVKSNAIVYAKDNQTIGIGAGQMSRVYSAKIAGIKAQDEGLEVAGCVMASDAFFPFRDGIDAAAKVGIQCVIHPGGSMRDQEVIDAADEHNMVMVLTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: Y1496_BRUME
Sequence: MTSSKTGQITIRSIGAGGDGVANLPDGQIYVPFTLPGEVVNVARDKNRATLMALLEASPERQNPACRHFEDCGGCALQHWQDEPYRLWKRELVVGALKGRGTDVEVAPLVACNPHTRRRAVFAARKTEKGVLLGFNRHQSHEIIDIVECPVTVPEIIARLDDLREVGALLAPGSGPFKLAATLTESGLDLAASGCGKLNDEQRRALTALVIKKDFARLSHEGEIIVEPKKPLIHFGKVPVPIPPGCFLQATAEAEETMAALVLAHLGKARRVADLFCGVGTFALRIAEKSAVHAVENDAAALAALDRGVRHVQGLKPVSIERRDLFRRPLMTKELLPYNAVVFDPPRAGAEEQALELAKSKVEKVVAISCNPVTLARDLAILQKGGYRIERVTPIDQFLWSAHVEAVAVLTKGRQ
What are the official names of this protein?
Uncharacterized RNA methyltransferase BMEI1496.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: SYD_MYCMS
Sequence: MKRTHTCGELTINNIDQEVILQGWVKKIRKLGAMVFIDLKDRYGITQLVVDQQHIDLINNVKNEYVIEIKGNVVKRKSINKELVTGDIEVIVKELFIINKSELTPFVLENDVNVNEDTRLTYRYLDLRRPVMQNNLIIRAKINHIIRNFLTDSNFLEVETPYFAKSTPEGARDFLVPSRLNKNKFYALPQSPQLFKQLLMISGIDRYYQIVRCFRDEDLRIDRQPEFTQLDLEMSFATSEDVMQISESLIKKILKEVKNFEIKEPLLRLSYKDAIDLYGSDKPDLRYDLKIHTLNDIFKNTNIKFLNNPDLFIRAICIDQLLSKKQLEDLNQQAKQFHFNSIAFIKFENNNWSGSLASQLTENEKELLIKEFDIKNKATIVLNIGKYEQISQLMGAIRISLAKMFNLETKDDFKLLWVVDFPLFEFSEQENRYVAAHHPFTSPKEECLTDFDTNKKDALTCAYDLVMNGFEIGGGSQRITNPEIQQRMFDAVELTTQQVETNFGWFMNAYKYGAPYHAGIAWGLDRISMIVTDSNSIRDVIAFPKNSLGIDMMSNAPDLVSEKQLEELNIKIVK
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XNI_SALEP
Sequence: MAAHLLIVDALNLIRRIHAVQGSPCVETCQHALDQLIIHSQPTHAVAVFDDDARSSGWRHQRLPDYKAGRPPMPDDLHNEMPALRAAFEQRGIRCWASDGNEADDLAATLALKVTEAGHQATIVSTDKGYCQLLSPGLRIRDYFQKRWLDAPFIEKEFGVLPRQLPDYWGLAGISSSKVPGVAGIGPKSATQLLIQFQNLEGIYAHLDEVPEKWRKKLETHKEMAFLCRDIARLQTDLHIDGNLQQLRLAR
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: PFD6_PLAF7
Sequence: MSQEKISEIIKDISALKTSCEKLNSQLDELITQKVENEMLLEEVKVLEDDSVLHKLVGLVLVKEEKSKCYDTISRRLQYITGEIENRKKVITNSEEKLRKLFSDLEAHAGQRKIPVPQA
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
What are the official names of this protein?
Probable prefoldin subunit 6.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
Protein: PURQ_MOOTA
Sequence: MKFGVIVFPGSNCDQDVHYALGSVLGQNVDYLWHGDTSVSGYDCLILPGGFSYGDYLRAGAIARFAPIMPAVIDFARSGGLVLGICNGFQILLEAGLLPGAMMRNACLQFRCQWTCLKVDNNATPFTNRFREGQVVRIPIAHGEGNYYADAATLAQLEANRQIIFRYCSPDGEVTPAANPNGSVGNIAGIINREGNVLGMMPHPERCAEGILGGSDGRELLASIVDWWERGERLGA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1677_METJA
Sequence: MDLQYFILAFSSIFSILNPFGAVPVFITLTESYPKKERDLVAKKTVIYALAILLAFALFGEWILKFFGISLDAFKIAGGILLLLISLDMVRGQQEAKIHRKEIEAAYEIDEIALMPLATPLLAGPGSITACMVAMAEASDIGDKFLVILAILLSLGITYLTLLSAESVLDRIGRLGIRILTRMMGLILTAIAVQMIVNGIRGALL
What are the official names of this protein?
UPF0056 membrane protein MJ1677.
What is the protein family that this protein belongs to?
Belongs to the UPF0056 (MarC) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SQD_DROME
Sequence: MAENKQVDTEINGEDFTKDVTADGPGSENGDAGAAGSTNGSSDNQSAASGQRDDDRKLFVGGLSWETTEKELRDHFGKYGEIESINVKTDPQTGRSRGFAFIVFTNTEAIDKVSAADEHIINSKKVDPKKAKARHGKIFVGGLTTEISDEEIKTYFGQFGNIVEVEMPFDKQKSQRKGFCFITFDSEQVVTDLLKTPKQKIAGKEVDVKRATPKPENQMMGGMRGGPRGGMRGGRGGYGGRGGYNNQWDGQGSYGGYGGGYGGYGAGGYGDYYAGGYYNGYDYGYDGYGYGGGFEGNGYGGGGGGNMGGGRGGPRGGGGPKGGGGFNGGKQRGGGGRQQRHQPY
What is the function of this protein?
This protein is a component of ribonucleosomes.  Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle.  At least one of the isoforms is essential in somatic tissues.
What are the official names of this protein?
RNA-binding protein squid, Heterogeneous nuclear ribonucleoprotein 40, HNRNP 40.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=It is possible that some isoforms are found only in one of these locations.
Protein: KNL1_MOUSE
Sequence: MDGVYSEANEENDNTQRPVRRQHSSILKPPRSPLQDLKCGNQTNQEPNPPRKRKSSRRVSFADTIKVFQTESHMKTERNSEISGMNTLLCAPIQTQMQQKEFSITDCNHERKHANDQTVIFSDENQMDLTASHTVMITKGLSDCTKNENSTKIDTTSFLENLKHHAANSRIKKDLACSTVSLSQNIFSEKINSDNFIKRLKTGKHISSSTELDKENAEIPVYSKDSNSASSTYQMHASLGVDENSSNRTRIFREQDDGMNLTQCHTACIKTWIPPSTEAKIGEFKGDKTIYGNECMELTTNYTIQVLSSENNLSERETQTQNGMNVTTVDGATAPAPEKKTALKDKLNAAFQGSFPNPENKIHIIKCHPIESETHTVTQISSQSASTLAVTSKSICSSPAIEGYKTIFHSSSNDAMELTKCLSAMEEEKKLLKADDKYSKICTNPDAGPLREKTIYLEEDSMDITKSHTVAIDNKIFKHDQENIKKEIIAIPIFEKEMVLRNLMPMSKDEKRDVNYISVPQVSKESLQRSQTNTLSVSLTDKKMEFLADEDMDLTKSHTTKLSQVIPTTFDLASKNVTKSYSHSKSPLNEWESLDKQVVLGQHSKLPLPQRKDRDDPDCSHHKIMYSEELQTMDLTKSHTIVIGFGPSEVQEHSKINLEHKNSQLTAESIQTAVNVPAANSRVVTTNDMDMLKDRSTHKPELLKEKQNIKIYGRKSIGRLKIDKTILFSEGNEGDMDITKSCTVKINHRSLLDKHDSHLVSLAGTSKTILHARGQVEMEINRSHTTPLECKIISPSDITPGDLDKTMMSIDDHEELDMTKSHTVFIDYQAEAKGVLPDRLDFQLSKKESLQKPKVTSLAEEIYISKNSESNHLPAKGSQLTILEEGSNSGLGEETNDAQKPGFLNELLSGKTQRRKSLSLKNKSITFPENDKSYREIPQSSAVEINNETRLEDRKGFSFVPLAGTSKPVLSAYGPEDMEISIGQTTASEYKTVPPEEITTIPMDKTVMFVDNFGDLDVTRSHTVFIDCQAKEKVLDEYTNLGIQKTKTLSGSEGDTHIQEITKNPAAQHKHHMTTVIPSSTVVSDQSSMKIKFHKADRDEEVKGKEVEANMLKQTKPESCLLNITDGKNVDFTSSYTADVCRSSDKYSSLPNISSSDNSGGNTMSLCDKNKEKAYNCQVPNEFTYAAILPSTYHMDSKKLSVFPPCPSKEVTQTESAIALLKDEDPVEEPLGEMATFNSKHVSLNLAKDQTEAFVDVSVASQPHLSAQQSPSTQKGQDVARRDEGILAKAGKKALPFLLENVAASTWENESKIPTNVEHFAVTYEKELSISIQTDKCNTNVQSPSNSALTTQVIQTHANAEGALDFLVPSTVSCFSSTKPSLSNLNRKTEEVLDFQTVNLLPPAEQLLEEGSQAHSMSIVQATEIYRLGSRNDRDEESKTFCNEAETTSVPLKTAVKDKTRRCSLGIFLPKLPSKRSCSITGVDDLEQILADAADLTQLETQPVCSKDPGIGSVAAKLNLSPSQFINEENLPVYPGEILSSDSVSLDIEESVLIDTSQRESLPSENKTENCRAQKRTRVEENDVTNEKKIRTHDSAQDQEVSCLEPKNVLEF
What is the function of this protein?
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment.  Directly links spindle checkpoint proteins BUB1 and BUB1B to kinetochores.  Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis.  Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (By similarity).
What are the official names of this protein?
Kinetochore scaffold 1, Cancer susceptibility candidate gene 5 protein homolog, Kinetochore-null protein 1, Protein CASC5.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle (By similarity).
Protein: COA3_KOMPG
Sequence: MAQPDKYYNKYTYQMSPAMLRARRPYFWKNMGAFGILGGISLSVYLYTYNFLMQDDFENIPIPPIKDEDLAALRREYEEKKQLSK
What is the function of this protein?
Required for assembly of cytochrome c oxidase (complex IV).
What are the official names of this protein?
Cytochrome c oxidase assembly factor 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COA3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: GATB_TALSN
Sequence: MPRLWYSRYLASARLRCRPLLISEQYGARIYQHLLRRTINTEANVQRPNDIVPLRKQLKEEAKRSKSQSRNGRGKKQVAANNEWELTVGIEIHAQLNSEAKLFSRAPTSTVAEPNSNVALFDLAFPGSQPEFQAATLLPALRAAIALNCEVQHTSRFDRKHYFYQDQPAGYQITQYYEPFARNGFIKLYDYDGIAPEDGKFVRIDIKQMQLEQDTAKSHEHPPSAHFLDFNRVSHPLIEIITMPQIHSPATAAACVRKIQAILQATSAVTTGMELGGLRADVNVSVRRRDAPPGAGEYYGVRGLGQRTEIKNLSSFKAVEDAIIAERDRQIRVLESGGTVEVETRGWSIGSTETRKLRSKEGEVDYRYMPDPDLHPLFIDDGLVSTLKENLPTLPDQLLAMLVGPMYGLSLEDAKPLVELDDGARLEYYQDVFDVLQALHSDDRDAAKKGLGRTAANWVLHELGALHTKAEVAWHADRIPAQTLAELIDQLIRKKITSSVAKQVLVMVFEGDQRPIQQLLEEENLLLRPLCREEYIALANSLIEENPQMVAQIREKNQLGKIGWFVGQMVRQGEKGRVEAQRAEEILRELILKRN
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial, Glu-AdT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
What are the subcellular locations of this protein?
Mitochondrion.