PharMolix/UniProtQA huggingface dataset:
Protein: PL1_ARATH
Sequence: MDDGVGVRAGCIRIRCPSPRRIVSRWLSPQGKVKGKKTPMAEPRVRDSDTVRIRTSSEDDHHRVGQFSDSPPPTIPSELQRREFLFSIGMSCYLIHLIATGRQEIHKIVELRNDLDKFLECRNEELRQKQQEFVELRNDIHKFLEFHNNELRRKQLEKTETSAYSATSDVVDGPESSTDHYYSPQIIQTSMSVGGEGSLSHYVYKLENDSGGEMDQLEAELEAEFELLQIGHNQEVSEDAEGLRLGHVCPGLVEEQQGVCPYELERRLYELMETRQQEEIKELEIALDDAKQRLHLKETEASWWKDTAYIVSERIPEPSRITHSSRTHPYPLSR
What is the function of this protein?
Acts as a stomatal lineage scaffold which regulates subcellular localization and transient polarization of kinases (e. g.  ASK7/BIN2 and ASK3/SK12) involved in asymmetric cell division (ACD) in a BASL-dependent manner.
What are the official names of this protein?
Protein POLAR-like 1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cell cortex. Note=Localized throughout the plasma membrane in asymmetric cell division (ACD) precursors (By similarity). Transient polar localization and segregation unevenly (distal to the newly divided meristemoid and parallel to the division plane) during meristemoid asymmetric divisions in a BASL-dependent manner (By similarity). Present in the cytoplasm of meristemoids and cell periphery in stomatal lineage ground cells (SLGCs), in a polarized pattern (By similarity).
Protein: GLMU_YERPE
Sequence: MSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGELLKKTLADPSLNWVLQAEQLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASDAQREINEINTGILVANGRDLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERVFQTEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKNCVIGDDSEISPYTVLEDARLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVANGATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_STAAT
Sequence: MNDLIINHIAELILPRSTDKPLKGKELDELNVVKNGTVVIKDGKIVYAGTHTDDYDATETIDASGKVVSPALVDAHTHLTFGGSREHEMSLKRQGKSYLEILEMGGGILSTVNATRETSEDDLFKKAEHDLLTMIKHGVLAVESKSGYGLDRENELKQLKVSNRLAEKYDLDMKHTFLGPHAVPKEASSNEAFLEEMIALLPEVKQYADFADIFCETGVFTIEQSQHYMQKAKEAGFKVKIHADEIDPLGGLELAIDEQAISADHLVASSDKGKEKLRNSDTVAVLLPATTFYLGKEDYADARGMLDNNGAIALATDYNPGSSVTNNLQLVMAIAALKLKLSPNEVWNAVTVNAAKAIDINAGTINTGDKANLVIWDAPNHEYIPYHFGINHAEKVIKDGKVIVDNTVSFKA
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_PHOLL
Sequence: MGGISIWQLLIIAVIVVLLFGTNKLRTLGSDLGASIKGFKKAIGDDNQPQQAQKTSSDADFETKNITEKQSVAQSETSESKNKEQV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ERA_XANC8
Sequence: MSETSPHRSGSVAVIGRPNVGKSTLTNALVGAKVSIVSNRPQTTRHRLLGIATFPEGQLMLVDTPGLHREQKRAMNRVMNRAARGSLEGVDAAVLVIEAGRWDEEDTLAFRVLSDADVPVVLVVNKVDRLKDKTALFPFLAQVSEGRTFAAVHPVSALKRKGLEALVSDLLKLVPEAEAMYGEDEITDRSQRFLAGELVREQLMRQLGEELPYATTVEIERFAEDGALLRIGAVIWVEREGQKAIVIGKGGTRLKDIGGKARLQMERLFGAKVFLETWVRVREGWSDDEAALKAFGYD
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: SYE2_RUEPO
Sequence: MPDQVVTRFAPSPTGFLHIGGARTALFNWLYARGRGGKFLLRIEDTDRARSTPEATAAILQGMAWLGLDHDGEVISQFERAPRHAEVALELLAQGKAYKCFSTQDEIQAFREAAQAEKRSTLFRSPWRDADPATHPDAPYVIRIKAPQSGETVIRDQVQGDVTIRNDQLDDMVLLRSDGTPVYMLAVVVDDHDMGVTHVIRGDDHLNNAARQMMIYQAMGWEVPVWAHIPLIHGPDGKKLSKRHGALGAQEYQAMGYPAAGMRNYLARLGWSHGDDEFFTDAQAREWFDLDGIGKSPARFDLKKLENLSGQHIAVSDDAALRHEIEAYLAAAGLPALTQTQSGDLERAMYCLKDRARTFPELIEKAAFVLASRPISPDEKAAAALASVSDGILAELTPQLQNASWTRESLEEALNAFAEAHGTKFGKLAAPLRAALAGRAVTPSVFDMMLVLGRDESLARLRDAAHPA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRSA_SALAR
Sequence: MTQANLSETLFKPRFKHTETSALVRRFNRGSQPPMQSALDGKNVPHWYRMINRLMWIWRGVDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWAKQAMDWQQKACQEQDAMRSGRYWLHASTLYNIAAYPHLKGDELAEQAQALANRAYEEAAQRLPGSLREMEFAVPGGSPVTAFLHMPKGDGPFPTVLMCGGLDAMQTDYYTLYERYLAPRGIAMLTLDMPSVGFSSKWKLTQDSSLIHQHVLKALTNVPWVDHTRVAAFGFRFGANVAVRLAYLEAPRLKAVACLGPVVHALLSDPQRQSTVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGFWKNDPFSPEDESRLITSSSSDGKLIEIPFNPVYRNFDKALQEITDWIHHRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: PPAC_BACCZ
Sequence: MEKVLVFGHKNPDTDAICSAIAYAELKKELGMNAEPVRLGEISGETQFALNYFKVEGPRFVETVANEVDNVILVDHNERQQSANDIESVRVLEVIDHHRIANFETSDPIYYRCEPVGCTATILNKMYKENGVTIRKEVAGLMLSAIISDSLLFKSPTCTEQDVAAARELAEIAGVDADKYGLEMLKAGADLSGKTMEQLISLDAKEFQMGNAKVEIAQVNAVDTNDVLVHQAELEKVISAVVEEKGLDLFLFVVTDILTNDSVGLAIGKAANIVEKAYNVSLENNTATLKGVVSRKKQIVPVLTEAFQA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_ACAM1
Sequence: MSNGALPNRSDVWLQSLGWQPTPEQEQQFERLFQLIVQANQQLNLTRITDPPDFWEKHLWDSLVGIAPWLQPDSSIQRQVSFSVDHSHPLKVIDIGTGGGFPGLPIAIIKPTWRITLLDSTQKKLAFLQQVNAELGLENVETCCDRAENLGQQSPYRESFDLAVIRAVGPASVCAEYALPLLALQGYAVLYRGQWTAEEQEGLVAATSKLGGELIAVSPVKMPHSQGIRHCIYLRKIKTTDPKFPRRVGVPARKPL
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WIN2_SOLTU
Sequence: MVKLSCGPILLALVLCISLTSVANAQQCGRQRGGALCGNNLCCSQFGWCGSTPEYCSPSQGCQSQCTGSGPDPGQGGSAQNVRATYHIYNPQNVGWDLNAVSAYCSTWDANKPYAWRSKYGWTAFCGPVGPRGRDSCGKCLRVTNTRTGAQTTVRIVDQCSNGGLDLDINVFQQIDTDGVGNQQGHLIVNYQFVNCGDNVNVPLLSVVDKE
What are the official names of this protein?
Wound-induced protein WIN2.
Protein: TFR1_PONAB
Sequence: MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCGGSICYGTIAVIIFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPEEDFPAAPRLYWDDLKKKLSEKLDTTDFTSTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLDTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAEMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQSLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELTERIPELNKVARAAAEVAGQFMIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLSALLENLKLRKQNNSAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF
What is the function of this protein?
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity).  Endosomal acidification leads to iron release.  The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.  Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).  Positively regulates T and B cell proliferation through iron uptake (By similarity).  Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity).  When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity).  When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
What are the official names of this protein?
Transferrin receptor protein 1, TR, TfR, TfR1, Trfr.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Melanosome.
Protein: NANA_SALNS
Sequence: MAKALQGVMAALLTPFDHQQQLDSESLRRLVRFNIGQGIDGLYVGGSTGEAFVQSLAEREQVLEIVAEEAKGKITLIAHVGTVSTAESQQLASAAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVSALKQTSGDLFQMEQIRRAHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVQALREGDVAKAQRLQTECNKVIDLLIKTGVFRGLKTVLHYMDVLSVPLCRKPFAPVDEKYLPALKALAQQLMEEKA
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOA_HAMD5
Sequence: MVLSSKNDQPDHLFAAPIEKLGDWAFDEQVAAVFPNMITRSIPGYTNIITMIGMLSKRFVKPHTQIYDLGCSHGAACLSIYPNILDIPSCKIIAVEESPAMIKYCRENLMAHCDQIPIEIIEDDILNIKIDNASMVILNFTLQFLDPGHRENVLNRIYQGLNPGGILVLSEKFHFEDPDIGPLLFDMHHDFKRAHGYSDLEISQKSTMLKNVMRIDSVETHQNRLRQAGFEQMDLWFQCFNFGSLLALKTSSSND
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: PTH_STAA9
Sequence: MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_XANAC
Sequence: MADRNEQILTPSQLNSLARDLLEGGFPLVWVEAELSSVTRPASGHLYFTLKDARAQIRCAMFKPKSTWLKFQPREGLRVLARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFDELRARLTAEGLFDAERKQALPAHVRRLAVITSPSGAAVRDVLSVLARRFPLLEVDLLPSLVQGDSAAAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAQTPVVSAVGHETDFSLSDFVADVRAPTPSVAAELLVPDQRELVARVRRAQARMTQLQQHALGNAMQRADRLALRLRAQSPQARLQLLHRRQEDAGRQLRARMMHVLERLQARVQRGQAQLQSHNPQRHLAGLQQRLRALHPQAAMQRRLQHDQLQLRRIARSLEAVSPLATVARGYAIVTRPANGSVVRSAAEVVTGERLRAQLADGSIEVRVESGES
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_ENT38
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHQVNFICADDAHGTPIMLKAQQLGISPEQMITEMSQEHQTDFAGFDISYDNYHSTHSDENRELSELIYTRLKENGFIKNRTISQLFDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPDAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTTSFDEYWKKDSDAELYHFIGKDIVYFHSLFWPAMLEGSGFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFIGKRFDGVMAAELADPALYKTFTDAATAIGEAWEAREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPTLSERAEAFLNTELTWDAIQQPLLSHKVNTFKALYNRIEMKQVEALVEASKEEVKAAAAPVTGPLADEPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQVLIGRQTVMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDEGAKPGQQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_LEGPC
Sequence: MSFDELPKSDGYQEKLVSVTRTAKVVKGGRVFGFAVLVVVGDGKGKVGFGRGKAREVPIAIQKAMDQAKKNMVYIPLSGTTIFHEITWNYGASKVFMKPASEGTGIIAGGAMRAVLEVLGVQNILAKSIGSTNPSNIVRATIGALTHIGTPDYVAAKRGKTVEEVMAG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: YCIB_RICCN
Sequence: MLKLLSEIGPVIAFFAGFFYGGGIQHATLYMLITSVICITLCYVIDKKVSKLSIISTTVLLVSGSITLISGDSMYIKIKPTILYVIFGIIFLMSGIRKNPFIKYALESIVRLKEESWITLSYRTAAFFFFMAVVNEVVWRNCSDETWVKFKVFGVIPITFIFILLQLPLLLKNKLPDSKI
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ERIF_HERER
Sequence: MPVFAQVAHEIDIFFSFSWRDWSASIIPGSIFAVGAMRGLTLPLTTLVARYIFLVTWLTPYIYFFTLLNQVTSVDEDMINKPNRPIPSGKVTLQGAQRRSIAAFSVFLGVALYEPSLLPETLCWISTTAFLCLTSYGNHWFGKNCIAMATGAWALLSASWKAISPSTPTSDTRIYAMCGWAALTTHIQDLRDVKGDAAVGRMTLPLVFGDMGSRFIITFLALPAACCILSLGGIFQLSPITLGSLHAILGHRVLRQAGSRYDHKTYMFYTYIFCFILMLSSMDSHGLI
What is the function of this protein?
Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of erinacines, cyathane-xylosides that show unique biological activities, including leishmanicidal activity, stimulating activity for nerve growth-factor synthesis, and agonistic activity toward the kappa opioid receptor (PubMed:31535864).  The geranylgeranyl diphosphate (GGPP) synthase eriE catalyzes the first step in erinacines biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:31535864).  GGPP is then substrate of the diterpene cyclase eriG for the production of cyatha-3,12-diene (PubMed:28371074).  EriG is unable to use geranyl diphosphate (GPP) or farnesyl diphosphate (FPP) as substrates (PubMed:28371074).  The cytochrome P450 monooxygenase eriI then hydroxylates cyatha-3,12-diene at C-14 of the seven-membered ring to produce erinacol, which is further hydroxylated at C-15 by the cytochrome P450 monooxygenase eriC to yield cyathadiol (PubMed:31535864).  The cytochrome P450 monooxygenase eriA then catalyzes C-11 hydroxylation in the presence of the short chain dehydrogenase/reductase (SDR) eriH, which leads to the production of cyathatriol (PubMed:31535864).  The acetyltransferase eriL converts cyathatriol into 11-O-acetyl-cyathatriol (PubMed:31535864).  The SDR eriH catalyzes further oxidation of 11-O-acetyl-cyathatriol into 1-O-acetylcyathin A3 (PubMed:31535864).  Finally, the glycosyl transferase eriJ tranfers xylose from UDP-xylose onto C-14 of 11-O-acetyl-cyathatriol to form eracine Q (PubMed:31535864).  EriJ is also able to convert 11-O-acetyl-cyathatriol to eracine Q2 by using UDP-D-glucose as cosubstrate, but at a lower rate (PubMed:31535864).  In the absence of eriL and eriJ, the SDR eriH is able to convert cyathatriol to cyathin A3; this is likely a switching mechanism in the biosynthesis of cyathins (C-14 ketogroup)and erinacines (C-14 glycosylated group) (PubMed:31535864).  The roles of the SDR eriB, the polyprenyl transferase eriF and the dehydrogenase eriK have still to be identified (Probable).
What are the official names of this protein?
Polyprenyl transferase eriF, Erinacine biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS15_SYNWW
Sequence: MALSLERKGEIIKTYQIHENDTGSPEVQIAILTERINYLNEHLKINSKDHHSRRGLLKMVGQRRSLLDYLKKKDFERYRSIVTRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RS11_HISS2
Sequence: MAKTPVRARKRVKKQVVDGVAHIHASFNNTIVTITDRQGNALAWATAGGSGFRGSRKSTPFAAQVAAERCAEVVKEFGLKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: SCX8_CENSU
Sequence: KEGYLVNSYTGCKFECFKLGDNDYCKRECKQQYGKGSGGYCYAFGCWCTHLYEQAVVWPLPNKTCN
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  This toxin compete with high affinity with 125I-Css4 bound on rat brain synaptosome and may bind with high affinity to Nav1. 1/SCN1A, Nav1. 2/SCN2A and Nav1. 6/SCN8A.
What are the official names of this protein?
Toxin Css8, Beta-neurotoxin CssVIII, Css VIII.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PNSB2_ARATH
Sequence: MASLISFSLLPKPKAVRSSISAPQTQTINTEKLEDKFGRKGIKFSESNNIPMVELKVRNGSSLKLSLSDAHVLSYKPKVYWKDEGFEEVLYTVDGDESRGGVGVVIVNGEEPKGGSSVISGCDWSVKDTDSDAIDALQIELSCTAGVLDITYIVSLYPVSMATALVVKNNGRKPVTLKPGIMSYLRFKKRSGAGIQGLKGCSYCPNPPLSSPFELLSPSEAMKAESSGWFGSEEGEKPGIWAVEDSVITLLEKKMSRIYGAPPAERLKAVYNTPPSKFETIDQGRGLFFRMIRIGFEEMYVGSPGSMWDKYGKQHYFVCTGPTSMLVPVDVASGETWRGAMVIEHDNL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
Photosynthetic NDH subunit of subcomplex B 2, chloroplastic, Protein PnsB2, NAD(P)H DEHYDROGENASE SUBUNIT 45, NDH-DEPENDENT CYCLIC ELECTRON FLOW 2.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: GLUQ_IDILO
Sequence: MYRGRFAPTPSGPLHLGSLVAAVGSYLDAKAHRGEWLVRIEDVDKPRAVPGAADTILTQLEAHGLEWDGSVLYQSQRDSVYQHQLNQLENAQRLYQCDCSRRAIRARSDHYDGYCRNRQPRSTPYALRFINNNPVDTFNDRAHGLLEDHSASVSEDFVLKRRDGLYAYQLAVVVDDIEQGITDIVRGSDLITPSFWQLTLWQYFTGKQPRMMHLPLIMNDDGLKLSKQNHAPSIESSQARNNLFTALDYLGIKPESELRHSPVSEILQQALQSWCKKWHIAGR
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: KHSE_GRABC
Sequence: MAVYTEVTDEALAAFLAEYDIGTAVAFRGIAEGVENSNYVLRTTGGDYILTLYEKRVDPNDLPWFLGLMEHLAARGITCPQPVRGRDGQALRMLCGRHAAITGFLPGVWPRKVQVAHCHPVGEVLAKLHEAGADYAPTRLNALGPEGWPPLLAICRSRADEISPGLGEELQKALDRVLTAWPSDLPAGHIHADLFPDNVFFLDDRLSGVIDFYFAATDALAYDIAIALNAWCFESDHAYNITKGSALLRGYNAIRTLTEAEKAALPVLCQGAALRFALTRLFDWLNTPPGAMVTRKDPMDYVHRLRFHLSAPNAGAYGL
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: RS19_PHOPR
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPVKTWSRRSMIIPQMIGLTIAVHNGRQHVPVFVSEEMIGHKLGEFAPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.