PharMolix/UniProtQA huggingface dataset:
Protein: SURA_BURMA
Sequence: MKKTLRFAAVASGLVASLITVAPSASAQALRAQGASLADEVVAVVNNDVITGRELDQRVGLIARRLQQQKAPVPPTDQLRAQVLNQMVLERIQVQRAKDDGIVVDNATVQATLGRLAQANGMQLDQYKARIEAQGVPWDLFVRDARTELMLSKLREKEVDSKITVSDAEVASYIASQRGPNAGSQQDLRLEHIFVKAPANAPQADIDVAQKKAEGLLQQALASGANFERLAKNQSEADDAKKGGDLGFKSPASLPSDVVDAVSKLRPGEVNPTLIRVPDGFEIVRLVERRASQNPAASPKIVQTHVRHILLRVGEGKSESQARQQLIDIRRQIESGGDFEKFARTYSQDGSASQGGDLGWISPGEPVPEFERAMNTLQDGQVSNPVRTEYGYHLIQVLGRRDAEGSVQQQMDIARQAIGQRKAEQAYSDWLRELRDSSYVQIKLPVAQ
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: SNF12_DICDI
Sequence: MSKNGTTGNKKKKTKLSTAATIAANIAKANATLNNNNNSNNNSNNTNIGNSINGIPSSLPPSVTLPVEELISFAPECLLFSQLLEFEEKLDASINKRLIDIQEASRRNSIKNIRTLRLSIYNTYSNQSAYYHLDNKSLNSVQERPSWSLRVEGKLLDESQDELVNKSIKSSSSSSSTANKRKFSSFFKKVFIQIGHRDTCEWDKSQTFTETDGFEIKRNGNQEVDIKILMYLDHVPQKYKVLGGLSQLLNIHTDTKPRIILALWHYIKSNTLLDAETKKITCDENLKNIFSLEELQFNQIPQLLREHLSPPDPLEFQYTLHLSGDAKDYEQAYDIQVEVDEPIFNPNPTMRKEISQLNDEINHHIQKVYQHKRKREFMEKLSSDPLGFLNDTTANLVKDFQVSKSTTSTGFEEERHASFYYQPMTEELVKNYLSKQTTPNPTPQQISMAPSTPQTP
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
What are the official names of this protein?
SWI/SNF complex component SNF12 homolog.
What is the protein family that this protein belongs to?
Belongs to the SMARCD family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYR_HALHL
Sequence: MKRHVASLLAQALKAMREAGELPADLELPEVQVERARDRAHGDYAANTAMVLAKPARQKPRDLAETIRSRLPASEAIAGVEIAGPGFLNFTLTTAARQESVRVALRQGAEYGRSDVGAGHRVHIEFVSANPTGPLHVGHGRGAAFGDALASVLEAAGYHVHREYYVNDAGRQMDILAASLWLRYLEAAGEPVSFPNKGYQGDYIVTHARELFEADGREHVRTAAELGAGLPAEDDDPEGYLDALVARSRELLGETAYRRVLDFALEAILGDIRADLDAFGVHYHRYFSERQLVDQGRIEHALERLDQAGYTYRADGALWFQASVFGDDKDRVLRRDNGLTTYFAADVAYHLDKIERGFDTLVNVWGADHHGYVPRVQAALKALGVDAERLDVRLVQFAILYRGGEKLPMSTRSGEFVTLRELRDEVGKDAARFFYVMRRSEQHMDFDLDLAKSESADNPVYYCQYAHARICSVFRQLEERGLACRVTPDEAALERLDAEHEAILLDLLGRYPEVIESAALAREPHQVAQYLRELAAAFHTYYNAVPFIIDDEALRDARLTLVQATRQVLANGLGLLGVDAPQSM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEN1B_HUMAN
Sequence: MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLKRPLKSLDGALYDDEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTPYSGEMDLLGEILDTLSTHSSDQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSSSGLTDSLFILKEENSNKHLGADNVSDPTSGLDFQLTSPEVSQTDKGKTEKRETLSQISDDLLIPGLGRHSSTFVPWEKEGKEAKETSEDIGLLHEVVSLCHMTSDFQQSLNISDKNTNGNQT
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822).  Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701).  Plays a role in clathrin-mediated endocytosis (PubMed:20154091).  Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822).  Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822).
What are the official names of this protein?
DENN domain-containing protein 1B, Connecdenn 2, Protein FAM31B.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle.
Protein: CLPP_AZOC5
Sequence: MRDPVDTYMNYLVPMVVEQTNRGERAYDIYSRLLKERIIFLTGPVEDGMSTLAVAQLLFLEAENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPAVSTLCIGQAASMGSLLLTAGEKGLRFALPNARIMVHQPSGGFQGQVTDIMLHAQEILSLKKRLNEIYVKHTGQPIEKIEDALERDNFMTANAAQEFGLIDTVIDKRPSDEPAKA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACL_SALPB
Sequence: MDYEFLRDVTGGVKVRMSMGHEVVGHWFNEEVKDNLSLLDEVEQAARTVKGSERSWQRAGHEYTIWMDGEEVMIRANQLDFSGDEMEEGMSYYDEESLSLCGMEDFLRVVAAYREFVSKA
What are the official names of this protein?
UPF0231 protein YacL.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: SYL_ACIBS
Sequence: MTISHIDPEYQANTIEPSVQQDWENRKVFKVADTVEGKHRYILSMFPYPSGKLHMGHVRNYTIGDVISRFYRLKGETVLQPMGWDAFGLPAENAAIAHKVAPAKWTFENIAYMRDQLKKLGLSVDWDREFATCTPEYYHWEQWLFVQLYKKGLIYRKLSTVNWDPVDQTVLANEQVENGRGWRSGALVEKRDIPMYYFRITDYAQELLDDLDTLQDGWPQQVLTMQRNWIGRSTGMEITFPSANTEIYADGLTVYTTRADTLMGVTYVAVAAEHPLALKAAENNPELAAFIEECRIGSVAEADLATAEKKGMATGLFVKHPVTGEELPVWIANYVLMSYGSGAVMAVPAHDERDFEFANKFNLPIKQVIDAKGADDADYSATEWQEWYGSKEGKLVNSGEFDGLEFQAAFDAFLAKLEPQGLANSKVQFRLRDWGVSRQRYWGCPIPMINCDTCGQVTVPEDQLPVVLPTDVVPDGSGNPLNKMPEFYETKCPCCGGDARRETDTLDTFVESSWYYARYASPDFTGGIVKPEAAKNWLPVNQYIGGVEHAILHLLYARFFHKLMHDEGVVQGNEPFTNLLTQGMVLADTFYREAENGKKTWFNPANIELERDEKGRIISAKYSGDGQEVIIGGQEKMSKSKNNGIDPQAIIDQYGADTARVFMMFAAPPDQSLEWSDAGVEGANRFLKRVWRLVASFLEKGNSATAIDKANLSKDAQDLRRKTHETIQKVSDDIERRHAFNTAIAALMELLNASNKFEAKDDNDVAVEREAITTLLTLLAPFAPHLSQTLLAQFGTDLTEATFPEVDASALTRNTQTIVVQVNGKLRGKLEVSVDISKDELLAQAKALPEVQQFLTGPTKKEIVVPNKLVNLVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3716_METBF
Sequence: MVGVKITWLGHSAFLLEAEKKLLIDPFISGNPLAPCSPEELNPDIITVTHGHRDHLGDTIEIGKRTRCRIITIHEVANYIKSKGVFAEGMGKGGTVNVEGIKLTMTDALHSSSIDASGFSFDGGSPAGFIIQINGHSIYHAGDTGVFGDMKLIGELYEPELVLLPIGDKFTMGIKEATKAVELILPRTVIPMHYSTFDVIKQDPEEFKRAVEAKVDTKVIIMKPGESIDL
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Mbar_A3716.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: TPMT_TERTT
Sequence: MKASFWHEKWKKREIGFHESVVNPALTDHWHALSAAGGSVFVPLCGKSLDLGWLLSQGVSVIGVELSEIAVQELFVSLDIEPSVSDVENFKLYSAENIAIWVGDIFNLNKAWLGVITAIYDRAALVALPESMRLEYAGKLIELSNCATQLLVTFEYDQSLHQGPPFSVPESAVQKCYGTRYQLQCLERKAVAGGLKGRIAATESVWKLSRNINS
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNAS1_ABRJE
Sequence: MGLEKSFILFPLLILVLGWVQSSLGKESPAMKFERQHMDSTGSSSSSPTYCNQMMKRRNMTQGSCKPVNTFVHEPLVDVHAVCSQENVTCKNGQKNCYKSHSTLHITDCRLKGSSKYPNCQYQTSQQQKHIIVACEGNPSVPVHXDAXV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSUB_ECO57
Sequence: MNTARLNQGTPLLLNAVSKHYAENIVLNQLDLHIPAGQFVAVVGRSGGGKSTLLRLLAGLETPTAGDVLAGTTPLAEIQEDTRMMFQDARLLPWKSVIDNVGLGLKGQWRDAARRALAAVGLENRAGEWPAALSGGQKQRVALARALIHRPGLLLLDEPLGALDALTRLEMQDLIVSLWQEHGFTVLLVTHDVSEAVAMADRVLLIEEGKIGLDLTVDIPRPRRLGSVRLAELEAEVLQRVMQRGESETRLRKQG
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BCHB_RHOCB
Sequence: MKLTLWTYEGPPHVGAMRVATAMKDLQLVLHGPQGDTYADLLFTMIERRNARPPVSFSTFEASHMGTDTAILLKDALAAAHARYKPQAMAVALTCTAELLQDDPNGISRALNLPVPVVPLELPSYSRKENYGADETFRALVRALAVPMERTPEVTCNLLGATALGFRHRDDVAEVTKLLATMGIKVNVCAPLGASPDDLRKLGQAHFNVLMYPETGESAARHLERACKQPFTKIVPIGVGATRDFLAEVSKITGLPVVTDESTLRQPWWSASVDSTYLTGKRVFIFGDGTHVIAAARIAAKEVGFEVVGMGCYNREMARPLRTAAAEYGLEALITDDYLEVEKAIEAAAPELILGTQMERNIAKKLGLPCAVISAPVHVQDFPARYAPQMGFEGANVLFDTWVHPLVMGLEEHLLTMFREDFEFHDAAGASHHGGKAVAREESPVAPADLAPAATSDTPAAPSPVVVTQASGEIRWMPEAERELRKIPFFVRGKAKRNTELYAAHKGVCDITVETLYEAKAHYAR
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: GREA_ALKOO
Sequence: MMADREVVLTAQGLKKLEDELELLKTVRRKEIAERIKQAIAFGDISENSEYDEAKNEQAQVEDRINKLETMLRKAVIIDEEDINTDIVSIGSIVQVNDLEFDEIVEYTIVGSTEADPYELKISNESPVGRALLGTKVGDVVEVQIPDGVTKYEILKITR
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: Y1942_ARCFU
Sequence: MATASADTLCSQQEDESWGNLMLHGFQVEAYKPVRVGDKVCYSFYLKNTGSSDVTLGKKGVYLHTNDGDLSSNSGATISPGKSIFVKDCFIASSSGEWTTYPGVCIITAKGEFCHNFETSCTFDVFIECPENWNCMTAEDASQGNYIRYSDELCGYTITGFTAMNKVRCTATEKLLNALQALGV
What are the official names of this protein?
Uncharacterized protein AF_1942.
Protein: DNAK_LEGPC
Sequence: MAKIIGIDLGTTNSCVAVMEGDKPKVIENSEGHRTTPSIVAFTDDNEILVGQSAKRQSVTNPEKTLFAIKRLIGRRFDDPIVQKDIKMVPYKIMKADNGDAWVRVKDQDKAPPQISAEVLRKMKKTAEDYLGEEVKEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAYGMDKKRGDSVIAVYDLGGGTFDISIIEIAEVDGEHQFEVLATNGDTFLGGEDFDLALIEYLASEFKKDTGIDLHNDPLALQRLKEAAEKAKIELSSAQQTDVNLPYITADASGPKHLNIKLTRAKLESLVEKLVERTIEPCKTALKDAGLTVSQINEVILVGGQTRMPLVQKTVEEFFGKEPRKDVNPDEAVAVGAAIQAAVLSGEVKDILLLDVTPLSLGIETMGGVMTKLIEKNTTIPTKATQVFSTADDNQTAVTVHVLQGEREQASANKSLGRFDLRDIPPAPRGVPQIEVTFDIDANGILNVSAKDKATGKAQSIVIKASSGLSEEEVAAMVKDAQSHAEEDKKFKEMAELRNQADSLIHSCEKSMKDLADELSEDEKKGIETAISELKEAVQGTDKARIEDKLKVLTDASAKMAERIYAKKSSEGQAAQGQTQSQESTKPAEEGVVDAEFEEVKEEDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PRXD1_BOVIN
Sequence: MAGAELRAALEQRLAALAIRTEVVEHPEVFTVEEMMPHIQHLKGAHSKNLFLKDKKKKGYWLVTVLHDRQINLNDLAKQLGVGSGNLRFADEAAMLEKLKVGQGCATPLALFCDDGDVKFVLDSAFLEGGHEKVYFHPMTNAATMGLSPEDFLTFVKNTGHDPIILNFDKN
What are the official names of this protein?
Prolyl-tRNA synthetase associated domain-containing protein 1, PrdX deacylase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PRORSD1 family.
Protein: AGAA_CORST
Sequence: MAQENLQKIVDSLESSRAEREELYKWFHQHPEMSMQEHETSKRIAEELEKLGLEPQNIGVTGQVAVIKNGEGPSVAFRADFDALPITENTGLDYSADPELGMMHACGHDLHTTALLGAVRALVENKDLWSGTFIAVHQPGEEGGGGARHMVDDGLAEKIAAPDVCFAQHVFNEDPAFGYVFTPGRFLTAASNWRIHIHGEGGHGSRPHLTKDPIVVAASIITKLQTIVSREVDPNEVAVVTVGSIEGGKSTNSIPYTVTLGVNTRASNDELSEYVQNAIKRIVIAECQAAGIEQEPEFEYLDSVPAVINDEDLTEQLMAQFREFFGEDQAVEIPPLSGSEDYPFIPNAWGVPSVMWGWSGFAAGSDAPGNHTDKFAPELPDALERGTQAILVAAAPWLMK
What is the function of this protein?
Hydrolyzes odorless N-alpha-acyl-L-glutamine conjugates of short- and medium-chain fatty acids, releasing human axillary malodor compounds (PubMed:12468539, PubMed:18492161, PubMed:17193210).  The enzyme is highly specific for the glutamine residue but has a low specificity for the acyl part of the substrate (PubMed:12468539, PubMed:18492161, PubMed:17193210).  The two most common products are 3-methyl-2-hexenoic acid (3M2H) and 3-hydroxy-3-methyl-hexanoic acid (HMHA), which are produced from the odorless precursors N-alpha-3-methyl-2-hexenoyl-L-glutamine (3M2H-Gln) and N-alpha-3-hydroxy-3-methylhexanoyl-L-glutamine (HMHA-Gln) (PubMed:12468539, PubMed:18492161, PubMed:17193210).  In addition, over 28 different carboxylic acids contributing to human body odor are released by this enzyme from odorless axilla secretions, including several aliphatic 3-hydroxy acids with 4-Me branches, 3,4-unsaturated, 4-Et-branched aliphatic acids, and a variety of degradation products of amino acids (PubMed:17193210).
What are the official names of this protein?
N(alpha)-acyl-glutamine aminoacylase, N-AGA, Axillary malodor releasing enzyme, AMRE.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20 family.
Protein: ATP6_XANP2
Sequence: MTVDPIHQFEIKRYVDLLNFGGVQFSFTNAALFMFGIVAIIFFFLTFATRGRTLVPGRAQSAAEMSYEFIAKMVRDSAGSEGMVFFPLVFSLFTFVLVSNVVGLIPYTFTVTAHLIVTAAMALLVIGTVIVYGFVRHGTHFLHLFVPSGVPAFLLPFLVVIEVVSFLSRPISLSLRLFANMLAGHIALKVFAFFVVGLASAGVVGWFGATLPFFMIVALYALELLVAMLQAYVFAVLTSIYLNDAIHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEF_CHESB
Sequence: MTDTRNLTQLGSKTQAPASPEAATLETAPFSRGDGPAAIVRFTCPEFTSLCPVTGQPDFAHIVIDYAPDKLLVESKSLKLFLTSFRNHGAFHEDCTVMIGRRIVEATKPLWLRIGGYWYPRGGIPIDVFWQTGTPPKDAWVPETGVPPYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_CAUVC
Sequence: MANVTVVGAQWGDEGKGKIVDWLSNRADVVVRFQGGHNAGHTLVVDGKVYKLALLPSGVVQGKLSVIGNGVVVDPWHLLSEIDKIADQGVAITPDLLILADNACLILPLHRDLDQAREAASTQKIGTTGRGIGPAYEDKVGRRAIRVADLADPEALKPKIERLLAHHGALRRGLGLPEANAQELFDALMELAPRILSYAQPAWRVLDQAYKAGRRILFEGAQGSLLDVDHGTYPFVTSSNTAAGQASAGSGMGPSATGFVLGIVKAYTTRVGEGPFPAELFDEVGKHLSTVGREVGVNTGRARRCGWFDSVLVRQSVAINGIHGVALTKLDVLDGLKTLKICVGYKIGDKVVDYLPAGLRDQAAATPVYEEIEGWTESTAGARSFKDLNANAIKYVRRVEELIGAPVALLSTSPERDDTILMRDPFQG
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUR_SHIFL
Sequence: MTDNNTALKKAGLRVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFELTQQHHHDHLICLDCGKVIEFSDDSIEARQGEIAAKHGIRLTNHSLYLYGHCAEGDCREDEHAHEGK
What is the function of this protein?
Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.  Regulates the expression of several outer-membrane proteins including the iron transport operon (By similarity).
What are the official names of this protein?
Ferric uptake regulation protein, Ferric uptake regulator.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL347_YEAST
Sequence: MEAEVSATVSVAYSTIVVKAEKADARALNSLSILFAAPIKPSTRAG
What are the official names of this protein?
Putative uncharacterized protein YLR347W-A.
Protein: SRP14_MOUSE
Sequence: MVLLESEQFLTELTRLFQKCRSSGSVFITLKKYDGRTKPIPRKSSVEGLEPAENKCLLRATDGKRKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKSKKSKPAQ
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).  SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity).  The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).
What are the official names of this protein?
Signal recognition particle 14 kDa protein, SRP14.
What is the protein family that this protein belongs to?
Belongs to the SRP14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIP_CAVPO
Sequence: HADGVFTSDYSRLLGQLSARKYLESLIXXXXXXXXXXXXXXXXXHSDALFTDTYTRLRKQMAMKKYLNSVLN
What is the function of this protein?
PHI also causes vasodilation.
What are the official names of this protein?
VIP peptides.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPA_METFK
Sequence: MQLSTSEISELIKSRLENFSTSAEARTQGTVISVTDGIVRIHGLSNVMAGEMIEFPGNVYGLALNLERDSVGAVILGDYENISEGDTVKCTGRILEVPVGPELVGRVVNALGQPIDGKGPINAKLTDKIEKVAPGVIARKSVSQPVQTGIKAIDSMVPVGRGQRELIIGDRQTGKTAVAVDAIINQKGQNMTCIYVAIGQKASTIANVVRKLEEHGAMEYTIVVAASASDPAALQFLAPYAGCTMGEYFRDRGQDALIVYDDLTKQAWAYRQISLLLRRPPGREAYPGDVFYIHSRLLERAARVNEEYVEKFTNGEVKGKTGSLTALPIIETAAGDVSAFVPTNVISITDGQIFLETDLFNAGIRPAINAGISVSRVGGAAQTKVIKKLGGGVRLALAQYRELAAFAQFASDLDEVTRKQLDRGRLVTELMKQAQYAPLSTSEMAVTLLAANKGFFDDVPVARALAFESALHSFLKSKYKSILDKIDSTNDLGGDDEKALEAAIQDFKATNAY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GUAC_STAAE
Sequence: MKIFDYEDIQLIPNKCIVESRSECDTTIQFGPKKFKLPVVPANMQTVMNEKLAKWFAENDYFYIMHRFDEEARIPFIKHMQNSGLFASISVGVKKAEFDFIEKLAQEKLIPEYITIDIAHGHSDSVINMIKHIKTHIPDSFVIAGNVGTPEGVRELENAGADATKVGIGPGRVCITKIKTGFGTGGWQLAALNICSKAARKPLIADGGIRTHGDIAKSIRFGASMVMIGSLFAAHEESPGETVELDGKQYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLMDTLKEMQQDLQSSISYAGGKDLKSLRTVDYVIVRNSIFNGDRD
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: RL2_SPHAL
Sequence: MALKSYNPTSPGQRGLILVDKSALWKGKPVKALTEGKRKTGGRNNKGHVTSRGIAGGHKQKYRFIDFKRRKWDVPATVERLEYDPNRTAFIALVKYEDGELAYILAPQRLAVGDTIVAGKKTDVKPGNAMELAQMPVGTIVHNIEMKPGKGGQIARSAGTYAQVVGRDRGLVIVRLGSGEQRYIRGECMGTVGAVSNPDNQNTNLGKAGRNRWLGKRPLTRGVAKNPVDHPHGGGEGRTSGGRHPVTPWGKPTKGARTRHNKSTDKMIIRSRHAKKKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DCTA_CITBB
Sequence: MKTKKFYQHLYFQVLTAISIGVAVGYYMPDTGTAMKPLGDGFIKMIKMIITPIIFCTVVTGIAGMDDMKKVGRVGGKALLYFEAVSTLALAIGLMVINVIQPGVGMNADVTKLDTKGLATYTATAAKSHSFADFALGIIPNSVVDAFAKGEILQVLFFAILFGLALSAMGEKGKPVYRMIDDVAHAFFGVVNIIMKFAPIGAFGAMAFTIGKFGLGSLTKLGMLMGSFYLTCLLFIFVVLGTIGKLCGFNIFKFISYIKEELLIVLGTSSSESALPRLMAKLENLGCSKSVVGLVIPTGYSFNLDGTSIYLTMAAVFVAQATNTPLDLTQTLTILGVLMLTSKGAAGVTGSGFVTLAATFAAIPTIPVAGLALILGIDRFMSEARALTNLVGNGVATVVVSRWENELNATRMSQVLNKELDEAAVEADLLMMDPEPEEA
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLYA_METMA
Sequence: MSYIEKIDPELFEAIKNEADRQEHKLNLIASENYASRAVMEAQGSIMTNKYAEGYSGKRYYGGCDFVDVAENLAIARAKELFGAKYVNVQPHSGSGANMAVYFSVLQPGDTILSMDLSHGGHLSHGSPVSFSGKLYNIVPYGVSKETEALDYDELLKLAKECKPRMIVCGASAYPRVIDFKRFREIADEVGAYLLADIAHIAGLVVAGVHPSPVPYADFVTTTTHKTLRGPRGGMIISKTEELAIGVNKAVFPGIQGGPLMHIIAAKAVAFKEAMSEEFRQDQDQTVKNAKVLCSCLKQKGFDIVSGGTDNHLMLVNLNNMNITGKDAEAALSKAGIIANKNTVPFETRSPFVTSGVRLGTPSCTTRGMKEKEMELVADYIEAAIKNSENDALLSEINIKVRDLCLKFPVYE
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.