PharMolix/UniProtQA huggingface dataset:
Protein: PUR7_PROMH
Sequence: MQKKAELYRGKAKTVYTTESSDYLILEFRNDTSALDGQRIEQFDRKGMVNNKFNYFIMNKLEEAGIPTQMERLLSDNEVLVKKLDMVPVECVIRNRAAGSLVKRLGIEEGTVLNPPIFDLFLKDDARHDPMVNESYCETFGWVSKENLAEMKRLSYKANDVLSELFDKAGLILVDFKLEFGLFNGKVVLGDEFSPDGSRLWDKNTLDKMDKDRFRQSLGGLIEAYEEVARRIGVSLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: PHL9_ARATH
Sequence: MYYQNQHQGKNILSSSRMHITSERHPFLRGNSPGDSGLILSTDAKPRLKWTPDLHERFIEAVNQLGGADKATPKTIMKVMGIPGLTLYHLKSHLQKYRLSKNLNGQANNSFNKIGIMTMMEEKTPDADEIQSENLSIGPQPNKNSPIGEALQMQIEVQRRLHEQLEVQRHLQLRIEAQGKYLQSVLEKAQETLGRQNLGAAGIEAAKVQLSELVSKVSAEYPNSSFLEPKELQNLCSQQMQTNYPPDCSLESCLTSSEGTQKNSKMLENNRLGLRTYIGDSTSEQKEIMEEPLFQRMELTWTEGLRGNPYLSTMVSEAEQRISYSERSPGRLSIGVGLHGHKSQHQQGNNEDHKLETRNRKGMDSTTELDLNTHVENYCTTRTKQFDLNGFSWN
What is the function of this protein?
Transcriptional activator that may activate the transcription of specific genes involved in nitrogen uptake or assimilation (PubMed:15592750).  Acts redundantly with MYR1 as a repressor of flowering and organ elongation under decreased light intensity (PubMed:21255164).  Represses gibberellic acid (GA)-dependent responses and affects levels of bioactive GA (PubMed:21255164).
What are the official names of this protein?
Myb-related protein 2, Myb family transcription factor PHL9, Protein NITROGEN STARVATION RESPONSE 1, AtNSR1, Protein PHR1-LIKE 9.
What is the protein family that this protein belongs to?
Belongs to the MYB-CC family.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Note=In 21% of the cells, localized to one or more spots within the nucleus due to protein aggregation.
Protein: Y860_ARCFU
Sequence: MVNHPCIVQVRDVQPDKIEIVRNMALKRNAEVEKAKNGLDIYFEDVNEARKFISKLRKSMKLRIKMSTKYAGLRGSRVRVLFVYSLRGL
What are the official names of this protein?
Uncharacterized protein AF_0860.
Protein: V1R47_MOUSE
Sequence: MNENSRLHTHSNIRNTFFSEIGIGISGNSFLLLFHIIKFFRGHRPRLTDLPIGLLSLIHLLMLLVAAVIATDIFISWRGWNDIICKFLVYLYRSLRGLSLCTTSMLSVLQAIILSPRSYCLAKFKRKSSHNISCAIIFLSVLYMSISSHLFISITATLNLTMNNFLYVSQSCSLLPLSYLMQSMYSTLLVLREVFLIGLMVLSTSYMVALLCMHRKQAQNLQGTSLSLKTAPEQRATQTILMLMTFFVLMSIFDSIVSSSRAMFLDDSTCYSIYIFVMHIYATVSPFVFMSTEKHLVNFFRSMCEWIINM
What is the function of this protein?
Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
What are the official names of this protein?
Vomeronasal type-1 receptor 47, Vomeronasal type-1 receptor A4, Vomeronasal type-1 receptor A7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YA4C_SCHPO
Sequence: MNILSRKENVASYFDIRVAAEHDLIVIQGLADSAEPTPLSGSVVLCLNEAISVKAISLKLVGKCRISWSEPSPTVRGGQRHNKQEYVVYEKNWIFVPYTGANRTLRAGNYEYPFHVMLPGDIAESVEGLQSCYVVYRLKASIDRTGLASKMVKKKHIRLIRALPADAIEYTQTISVDNTWPNKIEYTISVPTKAYAIGSYIPIHFVLVPLLKRLTIGKISITLKEYITLHVAHGYNGLPASKDEVRTVRSLQTEELEEFSDHYELTKNLELPSSLVECLQDCDLDGIKIRHKLKFSVSLRNPDGHISELRAALPVVLMIPPQLFGDRAEVESLRENFESFNQPLPSYQNSMYDRLYDGLSYSNLDTPLPSGATTPRRRDSMEPTYASNEAHRRQLIAGLTELALQQQPQGRSPNEHSPSNHPEDFPPSFSLGSNPSSGAASAVITRNPSETSLADLSRVPSYKEATRSAVPLESPLQSTLPSYEDVARIEHLSRPPSPGIVTPPQRTSPSFFVSPTESTRQSLDSRRSFEHSTSSSSGISPSHSSASLAHLSQASNPNGSSSAPHRPTSARVGSHRNALDALRRARMLPSGFSRRN
What are the official names of this protein?
Arrestin domain-containing protein C31A2.12.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: UBIC_BARBK
Sequence: MFRTEDSILPPLEWLSDNNSSVPPAIYDWLMELGSMTLRFERYCTRVHVEPRHEYFIARNELKEEAEHLPESSLYWLREVVLMGDNQPWLLGRTVIPQETLAHHSNALMNLGTLPLGRYLFSNGELTRDYIHIGRKDSLWARRSRLRLSGKPLLLTELFLADSPLYTEDPS
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_ALISL
Sequence: MTYFEAFFLALLQGFTEFLPISSSAHLILPSEVLGWSDQGLAFDVAVHVGTLAAVVMYFRKEVVTLLSAWTFSIVKKEHNKESKLAWLIILSTIPAAVCGLMFKDFIEVYLRSAWVIAITTIVFGLLLWWVDKNSTLVKDEYEMTWKKALFLGIAQAAAMIPGTSRSGITITAALYLGFTREAAARFSFLMSIPIITLAGSYLGLKLALSDAIIHFGFLGTGIIVSFISAYICIHFFLKLISSMGMTPFVIYRLLLGTSLLAWLALT
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASPD1_BORPE
Sequence: MNTPLRVGIVGCGVLANAMAGHLARQPRPVEIVGCLVRDPGRARGALPCHGSWEALLAQRPDVVVECAGQAALAQYAQAILAAGVDLVPASVGALADDALRGALLEAAAAAGARIRIPSGAMVGIDGLAAARHVGVAEVLYRGTMPPVALQRYVSGPLPERGLAFAGSAREAVARFPKNVNLTGTIALAGIGFDRTRVEMLIDPDATANVHELLARGEFGDFHARVSGLRISESSPSSRIVAGSLAQAALGSGFLALS
What is the function of this protein?
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
What are the official names of this protein?
L-aspartate dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the L-aspartate dehydrogenase family.
Protein: CX171_ARATH
Sequence: MTDQPAQNGLIPPPTSEPSKAAASAETKPKKRICCACPDTKKLRDECIVEHGESACTKWIEAHKICLRAEGFNV
What is the function of this protein?
Copper chaperone for cytochrome c oxidase (COX).  Binds 2 copper ions and delivers them to the Cu(A) site of COX (By similarity).  Can complement the yeast mutant cox17.
What are the official names of this protein?
Cytochrome c oxidase copper chaperone 1, Cytochrome c oxidase 17 copper chaperone, AtCOX17.
What is the protein family that this protein belongs to?
Belongs to the COX17 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: CH10_COXBR
Sequence: MKIRPLHDRVVVRRLEEERTSAGGIVIPDSAAEKPSRGEVISVGPGKPLDNGEVRSLDVKVGDQILFGKYAGTEVKLAGDEYIVMREDDIMGVIEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_XANC5
Sequence: MGQSVVVLGAQWGDEGKGKIVDLLTEEIGAVVRFQGGHNAGHTLVINGKKTVLHLIPSGILRDDALCLIGNGVVISPAALIKEISELEDAGVEVRSRLKISPAAPLIMPYHIALDQAREKAAGGKAIGTTGRGIGPAYEDKVARRGIRIADLHYPPQLEELLRTALDYHNFVLTKYLGVEAVDFQKTYDEALAFGEYVQPMKSDVAGILHDLRKQGKRVLFEGAQGALLDIDHGTYPYVTSSNTTVGGALAGTGVGADAIDYVLGIAKAYATRVGGGPFPTELDDEVGQGIRDRGAEYGASTGRPRRCGWMDIVALKRAVAINGISGLCITKLDVLDGMEKLKICIAYEYHGKRTEYAPLDAQGWEECTPVYLEFPGWSENTHGITVWDDLPPAARAYLRALEELAGCPISIVSTGPDRDHTMVLQDPFA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_LEPBP
Sequence: MNYPFQDIEQKWQKYWDHHQTFRTNTHSSKPKYYCLDMFPYPSGAGLHVGHPEGYTATDIISRLKRMEGYEVLHPMGWDAFGLPAERYAMTTGIHPRTTTKNNIDTFRRQIKSLGLSYDWEREISTTHPDYYRWTQWIFLQIYNSYFDRKQNKAVPITTLIQTLEREGSLFFEGVELPKGIQFTASEWKSKSRKEKEDILSHFRLVYEANIPVNWCEALGTVLANEEVEEWTSKGYSVERKPMRQYMMRITAYAERLLNDLSLCEWPPSTLEMQRNWIGKSEGLELSFHVPSLNKDITVYTTRPDTIFGATYLVLAPEHALVAELTTPEQTEAVGQYQKDCSLKSDLERTELNKDKTGVFTGAYAQLPTDPSVKVPIYISDYVLISYGTGAIMAVPAHDQRDYDFAVKFNLPIKQVIDGKMETNLAFDSKDSVCINSSSAEVQLDGKSYKDAFQTMVVWAEKKGIGRKKIQFKLRDWLFARQRYWGEPIPLVHFEDGSPKALSDSELPLVLPDLEEFKPSGTGESPLALAKDWLVYKDPETGEIGKRETNTMPQWAGSCYYYLRYIDPRNNDKLIDPELEKMWMPVEVYVGGAEHAVLHLLYSRFWHKILFDLGHVSTPEPFKKLVHQGLILGEDKGKMSKSRGNVVNPDDVVSEFGADTLRLFEMFMGPFEMSKPWSKNGVDGVFRFLNRVWRLFHSGENESFFVEDIEPNEAEQKTLHRTIKKVKDDIDSFSFNTAVSQMMIFINEFTSNPRKPKQVLEPFVLALSPFAPHLAEELWAKLGHTDSLAYHPYPKWDEKYLIDANITIVVQVNGKMRGEFLAPREIEEKEALSLAKEVEKAKPFWVGKEIKKEIYVKGKLVNIVVAG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERC_BORA1
Sequence: MARPWNFSAGPSALPESVLQQAAAEMLDWHGSGMSVMEMSHRGRQFVQICDEAEADLRELMNVPADYAIMFMQGGGLGENAIVPMNLIGRRGLPAADFVVTGHWSTRSHKEAGRYGDAQIAASSAQAVNIDGHEQRPFTWVPPLSDWRVRPEAAYLHLCSNETIGGVEFTEWPDLAAFGAPDVPLVVDASSHFLSRPLDVTRTGLLFAGAQKNAGPAGVTVVIARRDLLGKALSICPSAFDYANVAAEHSRYNTPPTFAIYVAGLVYKWVKAQGGVQGLEAANKAKADLLYGYLDASGFYRNPVHPAVRSRMNVPFVLHDESLNDAFLKGAEAAGLLALKGHKSVGGMRASIYNAMPLAGVQALVDYLKEFERLHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_STRS7
Sequence: MSNILRKVIENDKGELRKLEKIAKKVESYADYMESLSDKDLQAKTPEFKQRYQNGETLEQLLPEAFAVVREAARRVLGLYPYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNALAGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKSPAEKREAYLCDITYSTNSEVGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADMFVKTLDSVDYIIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFVDNALRANYIMLLDIDYVVSEEGEILIVDQFTGRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIARIDHTDLLYATLNSKFKAVVADVKARYEKGQPVLVGTVAVETSDLISKKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDELMRRFGTDRIKAFLDRMNNDDEDIVIKSRMLSRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDRAVDAHSRTNRKDAIDAIVTFARTSIVPEETIGAKELRGLKDDQIKDKLYQRALEIYDKQLSKLRDQDAILEFQKVLILMIVDNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQSEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERATQYATTTAAQNIQSQAIGDDFDSSADFSRVERNDACPCHSGKKFKNCHGRKAF
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: ALLB_ECOL5
Sequence: MSFDLIIKNGTVILENEARVVDIAVKDGKIAAIGQDLGDAKDVMDASGLVVSPGMVDAHTHISEPGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELGQPVLVHCENALICDALGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHVCHVSSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEIDCLVSDHSPCPPEMKAGNIMKAWGGIAGLQSCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQKGRIAPGKDADFVFIQPNSSYVLTNDDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ
What is the function of this protein?
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
What are the official names of this protein?
Allantoinase, Allantoin-utilizing enzyme.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
Protein: CDYL_HUMAN
Sequence: MTFQASHRSAWGKSRKKNWQYEGPTQKLFLKRNNVSAPDGPSDPSISVSSEQSGAQQPPALQVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQKESTLTRTNRTSPNNARKQISRSTNSNFSKTSPKALVIGKDHESKNSQLFAASQKFRKNTAPSLSSRKNMDLAKSGIKILVPKSPVKSRTAVDGFQSESPEKLDPVEQGQEDTVAPEVAAEKPVGALLGPGAERARMGSRPRIHPLVPQVPGPVTAAMATGLAVNGKGTSPFMDALTANGTTNIQTSVTGVTASKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEVMREVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMAEAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLLSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF
What is the function of this protein?
Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672).  Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.
What are the official names of this protein?
Chromodomain Y-like protein, CDY-like, Crotonyl-CoA hydratase.
What are the subcellular locations of this protein?
[Isoform 2]: Nucleus. Chromosome. Note=Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is required for chromatin-binding (PubMed:19808672). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481).
Protein: VE7_HPV26
Sequence: MHGNIINIEDVILDLVPQPEIDLRCYEQLDYEQFDSSDEDETDNMRDQQARQAGQEVCYRIEAQCCMCNSIVQLAVQSSRQNVRVLEQMLMEDVSLVCHQCAAQ
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: METH_HUMAN
Sequence: MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD
What is the function of this protein?
Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:16769880, PubMed:27771510, PubMed:17288554).  MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis.  Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed:16769880, PubMed:27771510, PubMed:17288554).  The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:16769880, PubMed:27771510).
What are the official names of this protein?
Methionine synthase, MS, 5-methyltetrahydrofolate--homocysteine methyltransferase, Cobalamin-dependent methionine synthase, Vitamin-B12 dependent methionine synthase.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 dependent methionine synthase family.
Protein: GATB_AGRFC
Sequence: MTLVDVRTPDPKRFIPGATGDWEIVIGLEVHAQVLSNSKLFSGASTTFGNAPNSNVSLVDAAMPGMLPVINEECVKQAVRTGLGLKAKINNRSIFDRKNYFYPDLPQGYQISQFKDPIVGEGTITISLGPDRQGNFEDIEIGIERLHLEQDAGKSMHDQHPTMSFVDLNRSGVALMEIVSKPDMRSSDEAKGYLTKLRSIVRYLGTCDGNMDEGSMRADVNVSVRRPGEGFGTRCEIKNVNSIRFVGQAIEYEARRQVAILEDGGVIDQETRLFDPGKGETRSMRSKEDAHDYRYFPDPDLLPLEFDDAFVEALKVDLPELPDDKKARFVADLGLSVYDASILVSEKAIADYYEAVAAGRDAKTAANWVINDLLGALNKFGKDIETTPVSPDQLGGIIDLIKAETISGKIAKDLFEIVWNEGGNPAEIVEARGMKQVTDTGAIEKAVDDIIAANPDQVEKVKAKPTLAGWFVGQVMKATGGKANPQAVQALVKAKLGIEDE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: WECC_METM5
Sequence: MEKHGNYNINKICVIGLGYIGLPTASMLANHGYEVVGVDVNEKRVNQIKNGELKIEEPGLLTLVKGAINSKNLNVQTSATEADAFIICVPTPALENEDGSKKCDLTYVMGAVQNIIPFLKEGNLIVIESTIPPEITKKIYETIDKKIYVAHCPERVLPGKILKELVENDRIIGGINKKSAEMAKEIYKSFVEGKIYITDSNTAEMVKLMENTYRDINIALANEFAKICDEIGVNVWDAIKIANKHPRVNILNPGPGVGGHCISIDPWFIVEKTNNAKFIRAARELNDNMPAYVCKSVLSELKKHGIKKPKISVFGATYKGNVEDTRESPSKNVIEMLLKNGVTVSTFDPHATCFEYPLSTLDECISGSDCIVVLTDHDAFKNIKKDDIDEICPKLKNKIVFDTKNILEHNLWKRAGFTVKLLGNGAW
What is the function of this protein?
Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
What are the official names of this protein?
UDP-N-acetyl-D-mannosamine dehydrogenase, UDP-ManNAc 6-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Protein: COBQ_SORC5
Sequence: MTALTVMVQGTASSVGKSLLCAALCRIFQRRGLRVAPFKSQNMALNSFATLDGGEIGRAQAVQAEAARVAPTVDMNPVLLKPEGDSRSQVIVLGKPIGSLHARDYFAYRGELKDIIARSLGRLREAHDVVVIEGAGSPAEINLKDRDIVNMHVARAADAPVLLAGDIDRGGVFAALVGTMALLEPDERARVAAFVINKFRGDLKLLEPGLDMLTARTGVPVLGVVPYLKQLRIADEDSVSLEGRRRRAPAGPGELDIAVVRLPRISNYDDVEPLEHEPGVVVRFIERPDEIGNADLVLLPGTKSTMADLAWLRASGLAEAVAARARQGGWTLGICGGCQMLGGAIEDPEGVESAEPAARGLGLLDVWTRFERTKTVAQVRARLAGGSFLGPAGAVNAGEAEGEGAGELTGYEIHMGRVERVGGAAAAFAIGSRGGKAEPALDGAVSADGAVVGTMIHGILDNDGLRRSLLAALRERRGLPRAAGEPAIPSRHEEYDRLANAVEASLDRALLDRIVGLDRR
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: CPFC_MYCBO
Sequence: MQFDAVLLLSFGGPEGPEQVRPFLENVTRGRGVPAERLDAVAEHYLHFGGVSPINGINRTLIAELEAQQELPVYFGNRNWEPYVEDAVTAMRDNGVRRAAVFATSAWSGYSSCTQYVEDIARARRAAGRDAPELVKLRPYFDHPLFVEMFADAITAAAATVRGDARLVFTAHSIPTAADRRCGPNLYSRQVAYATRLVAAAAGYCDFDLAWQSRSGPPQVPWLEPDVTDQLTGLAGAGINAVIVCPIGFVADHIEVVWDLDHELRLQAEAAGIAYARASTPNADPRFARLARGLIDELRYGRIPARVSGPDPVPGCLSSINGQPCRPPHCVASVSPARPSAGSP
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL20_HCMVM
Sequence: MLGIRAMLVMLDYYWIQLITNNGTRSNNTDTIFVSLLTGPNGVTRTAIGGLYSNYTNLTGAFGFTSTNMSATNSSAEDNWSVTNLTESCINRGESYVTTIWLLDCTKNDTYWYYGNAYNHTCEGTISGYLLGMCKLWKSWVNNITSYNTVRVESLGNETRCMLLPRQYTLNATVEWYNKSEGDVPEEFMDYVILTPLAVLTCGLQEAYILDKGRRYMYLFSVSCVGITGTVSIILVSLSLLILICYYRCGRLLICPRGFELLPEFTEEEEEKEKLLTHNDIEVQVPIRTRRLLVPWIRESKMWVLPPPLPPRPPHLIEFPPSPPPSPGPMHMVVCMPA
What are the official names of this protein?
Membrane protein UL20.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL20 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Does not reach the host cell surface but is rapidely targeted to endosomes and lysosomes.
Protein: VM3S_CROSS
Sequence: NPCCDAATCKLKSGSQCGHGDCCEQCKFSKSGTECRASMSECDPAEHCTGQSSECPADVFHKNGQPCLDNYGYCYNGNCPIMYHQCYDLFGADVYEAEDSCFERNQKGNYYGYCRKENGNKIPCAPEDVKCGRLYCKDNSPGQNNPCKMFYSNEDEHKGMVLPGTKCADGKVCSNRQ
What is the function of this protein?
Snake venom metalloproteinase that impairs hemostasis in the envenomed animal.
What are the official names of this protein?
Zinc metalloproteinase-disintegrin-like scutiarin, Snake venom metalloproteinase, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MSHC_STANL
Sequence: MESWQAPDLKRLGGQAVPLRLYDTARQAVHATEPHPDGARMYVCGITPYDATHLGHAATMVTFDVINRVWRDNGHDVAYVQNVTDVDEPLFERAERDGEDWVVLGMRETALFREDMEALSIIPPKAYVGAVESMPTIAALVERLVDAGAAYTVDDGTGDVYFPVTATEGFGSESHYDRDTMLRFFGERGGDPDRSGKRDPLDALLWRGEREGEPSWESRLGRGRPGWHIECAAIALAHLGDRIDVNGGGNDLIFPHHEFSAAHAEAATKAVPFAKHYVHAGMIGLDGEKMSKSRGNLVFVSRLRADGVDPAVIRLALLDGHYREDRPWTAELHAAAADRLARWREAMGMSSGASGTTTAQRVRERLSDDLDTPGALRAVDEWAAASLTGAHHDAHAPALVRDTVESLLGVTLLRAVFRQRTTSATTLDRSR
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.