PharMolix/UniProtQA huggingface dataset:
Protein: FRDD_SALPB
Sequence: MINPNPKRSDEPVFWGLFGAGGMWGAIIAPVIVLLVGIMLPLGLFPGDALSFERVLTFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTAIGVITL
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GNIH_COTJA
Sequence: MEIISTQKFILLTLATVAFLTPHGACLDELMKSSLESREDDDDKYYETKDSILEEKQRSLNFEEMKDWGSKNFMKVNTPTVNKVPNSVANLPLRFGRSNPEERSIKPSAYLPLRFGRAFGESLSRRAPNLSNRSGRSPLARSSIQSLLNLSQRFGKSVPISLSQGVQESEPGM
What is the function of this protein?
Hypothalamic factor, responsible for the negative regulation of gonadotropin secretion.
What are the official names of this protein?
Gonadotropin inhibitory hormone peptides.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL25_FLAPJ
Sequence: MKSITIKGSERESVGKVATKALRNAGAVPCVLYGGDQPVHFSADERAFKSLVYTPNAHTVVIEVEGGKSYNAVMQDIQVHPVTDKILHLDFYQLFEDKEVTMEVPVRIIGTSPGVLLGGVLRLNSRKLKVKALPANLPDFLDADISPLEMGNKIYVTALANEKYKILHPENTVVCQVRISRAAMKAAQEAAKAAKAPAGKKKK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: HFQ_LEPBL
Sequence: MSAKNNIQDQLLNTARKDKLDLTIYLLNGVPLKGKVVSFDNFTIVLEQENKQSLVYKHAISTIIPAKIIKLYTEETKDAVQG
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: CRCB1_BRUAB
Sequence: MLDIIILVVIGGAFGAMTREFIMLMVPPLTDGFPLDILVANVVACFLLGTVTALYARKIHSRDVHTIIGTGMMGGVSTFSSFAYGSVVLASASMSAFLIAAAYVTVSVVAGYVAVLAGMKFGEKSADILHRYPPMASIIDSGLVTVESRHSVAETIERVAAKAKSMGMNVFTRVDHGAGAKEAGLGLPPTELIIFGNPQNGTVLMQDKRTIGLDLPIRALAWEDGSGKVWLTVNDPAWLAQRHSLGLSSDVAIKAMVTGTGTVTKYAAGD
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PEPQ_SHIDS
Sequence: MESLASLYKNHIATLQERTRDALTRFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILLPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: MP2_MNSV
Sequence: MACCRCDSSPGDYSGALLILFISFVFFYITSLSPQGNTYVHHFDSSSVKTQYVGISTNGDG
What is the function of this protein?
Cell-to-cell movement function.
What are the official names of this protein?
Double gene block protein 2, DGBp2, Movement protein P7B.
What is the protein family that this protein belongs to?
Belongs to the gammacarmovirus double gene block protein 2 family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: DMSD_SALTI
Sequence: MTTFLQRDDFAVTARVLGALFYYSPESHETAPLVQALLNDDWQAQWPLDAEALAPVAAMFKTHSEESLPQAWQRLFIGPYALPSPPWGSVWLDRESVLFGDSTLALRQWMRENGIQFEMQQNEPEDHFGALLLLAAWLAENGRHHECEQLLAWHLFPWSPRFLDVFIDHAGHPFYQALGQLARLTLAQWQAQLIIPVAVKPLFR
What is the function of this protein?
Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system.  May be part of a chaperone cascade complex that facilitates a folding-maturation pathway for the substrate protein.
What are the official names of this protein?
Tat proofreading chaperone DmsD, DMSO reductase maturation protein, Twin-arginine leader-binding protein DmsD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. DmsD subfamily.
Protein: NPHA1_RHOSO
Sequence: MTTSAFVDDRVGVPNDVRPMTGDEYLESLRDGREVYFRGERVDDVTTHPAFRNSARSVARMYDALHQPEQEGVLAVPTDTGNGGFTHPFFKTARSADDLVLSRDAIVAWQREVYGWLGRSPDYKASFLGTLGANADFYGPYRDNALRWYKHAQERMLYLNHAIVNPPIDRDKPADETADVCVHVVEETDAGLIVSGAKVVATGSAITNANFIAHYGLLRKKEYGLIFTVPMDSPGLKLFCRTSYEMNAAVMGTPFDYPLSSRFDENDAIMVFDRVLVPWENVFAYDTDTANGFVMKSGFLSRFMFHGCARLAVKLDFIAGCVMKGVEMTGSAGFRGVQMQIGEILNWRDMFWGLSDAMAKSPEQWVNGAVQPNLNYGLAYRTFMGVGYPRVKEIIQQVLGSGLIYLNSHASDWANPAMRPYLDQYVRGSNGVAAIDRVQLLKLLWDAVGTEFGGRHELYERNYGGDHEAVRFQTLFAYQATGQDLALKGFAEQCMSEYDVDGWTRPDLIGNDDLRIVRG
What is the function of this protein?
Utilizes the flavins supplied by NphA2 to catalyze the degradation of 4-nitrophenol (4-NP) via 4-nitrocatechol (4-NC) which is used as the sole carbon, nitrogen, and energy source.  Can also degrade phenol and 4-chlorophenol as rapidly as 4-NP.
What are the official names of this protein?
4-nitrophenol 2-monooxygenase, oxygenase component, 4-nitrophenol hydroxylase, 4-NP hydroxylase, Two-component 4-nitrophenol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the FADH(2)-utilizing monooxygenase family.
Protein: PPX_ECOL6
Sequence: MPIHDKSPRPQEFAAVDLGSNSFHMVIARVVDGAMQIIGRLKQRVHLADGLGPDNMLSEEAMTRGLNCLSLFAERLQGFSPASVCIVGTHTLRQALNATDFLKRAEKVIPYPIEIISGNEEARLIFMGVEHTQPEKGRKLVIDIGGGSTELVIGENFEPILVESRRMGCVSFAQLYFPGGVINKENFQRARMAAAQKLETLTWQFRIQGWNVAMGASGTIKAAHEVLMEMGEKDGIITPERLEKLVKEVLRHRNFASLSLPGLSEERKTVFVPGLAILCGVFDALAIRELRLSDGALREGVLYEMEGRFRHQDVRSRTASSLANQYHIDSEQARRVLDTTMQMYEQWREQQPKLAHPQLEALLRWAAMLHEVGLNINHSGLHRHSAYILQNSDLPGFNQEQQLMMATLVRYHRKAIKLDDLPRFTLFKKKQFLPLIQLLRLGVLLNNQRQATTTPPTLTLITDDSHWTLRFPHDWFSQNALVLLDLEKEQEYWEGVAGWRLKIEEESTPEIAA
What is the function of this protein?
Degradation of inorganic polyphosphates (polyP).  Releases orthophosphate processively from the ends of the polyP chain.
What are the official names of this protein?
Exopolyphosphatase, ExopolyPase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y1394_ARCFU
Sequence: MNVEFVRDEGIAIELNGRSYYVRASHLGVKDGKILLCLDFAAPTALEPVKTFLKSYSKIRGARYAVLISGEERWIYDNYLGREVDEVEERVVEVRAEEKDYRLAAAFYALIHCECGVGDEGNCLCGLPPEW
What are the official names of this protein?
Uncharacterized protein AF_1394.
Protein: UN93A_DANRE
Sequence: MSRNTKNVLVVSFGFLLLFTAYGGLQSLQSSLNAEEGMGVISLSVIYAAIILSSMFLPPIMIKNLGCKWTIVVSMGCYVAYSFGNLAPGWASLMSTSAILGMGGSPLWSAKCTYLTISGNRQGQKHNKKGQDLINQYFGIFFFIFQSSGVWGNLMSSLIFGQDQNIVPKENLEFCGVSTCLDNFTVIGNSTRPSKHLVDTLLGCYIGVGLLAIIFVAVFLDNIDRDEAKEFRSTKGNKSFWDTFLATFKLLRDPRLLLLIPLTMYSGFEQSFLSGEYTKNYVTCALGIHNVGFVMICFAASNSLCSFAFGRLAQYTGRIALFCLAAAINLGSFLGLLYWKPHPDQLAIFFVFPALWGMADAVWQTQTNALYGILFAKNKEAAFANYRMWESLGFVIAFAYSTFICLSTKIYIALAVLALTMVTYLYVEYNEYKHPTPQVTEDFLKPIKPKLKDDKEDNIISQTQL
What are the official names of this protein?
Protein unc-93 homolog A, Unc-93A.
What is the protein family that this protein belongs to?
Belongs to the unc-93 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL17_YERPB
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMAGSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDNVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRAASQAEVVAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RL31_ALISL
Sequence: MKVGIHPEYKAVKATCSCGNEFEFKSALGKDTIHLDVCGECHPFYTGKQRIVDTGGRVDRFNKRFGAIGSKK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: VIRF3_HHV8P
Sequence: MAGRRLTWISEFIVGALDSDKYPLVKWLDRSTGTFLAPAARNDVIPLDSLQFFIDFKRECLSKGLHPRDLLGSPITAFGKICTTSRRLRRLPGEEYEVVQGINCRRWRLLCAEVKECWWCVHARTHLHSGSSLWEILYQHSVRLEKHRRRPRPFVGENSDSSEEDHPAFCDVPVTQTGAESEDSGDEGPSTRHSASGVQPVDDANADSPGSGDEGPSTRHSDSQPPPADETTVHTDNVEDDLTLLDKESACALMYHVGQEMDMLMRAMCDEDLFDLLGIPEDVIATSQPGGDTDASGVVTEGSIAASAVGAGVEDVYLAGALEAQNVAGEYVLEISDEEVDDGAGLPPASRRRPVVGEFLWDDGPRRHERPTTRRIRHRKLRSAYYRVARPPVMITDRLGVEVFYFGRPAMSLEVERKVFILCSQNPLADISHSCLHSRKGLRVLLPKPDDNNTGPGDVNLLAAVLRSFASGLVIVSLRSGIYVKNLCKSTVLYHGNNPPKKFGVICGLSSRAVLDVFNVAQYRIQGHEHIKKTTVFIGGDPTSAEQFDMVPLVIKLRLRSVTCDD
What is the function of this protein?
Plays a role in the inhibition of host immune response.  Interferes with the transactivating potential of cellular IRFs IRF3 and IRF7 that play a critical role in the induction of IFNA and IFNB genes.  Additionally, interferes with surface major histocompatibility complex class II (MHC-II) antigen presentation.
What are the official names of this protein?
Viral IRF3-like protein, VIRF-3.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
Protein: RS20_STRP7
Sequence: MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELFRAASSAIDKAETKGLIHKNKASRDKARLSAKLAK
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: PGAP2_XENTR
Sequence: MVPVGPERGANSLFSLRFTTFAVGTVSLPLFAFLFCIVWSLLFNFSETTATHCHVPNYLPSVSAAIGGETPQRYIWRLCIGLHSAPRFLVGVAYLHYYQGTPCSSPAYPRLCHLNFLLNCCEIFFLILLTYVSSSENYEVHKLGFMAFMLFSVGYMFVTCSLWRVARKGSGSLEERTSYAWKKRLFGFYLLMFLSSILVYIWHNMYCEAGVYTVFALLEYLVVLSNMGFHMTAWWDFGNKELMICSPGDKRI
What is the function of this protein?
Involved in the lipid remodeling steps of GPI-anchor maturation.  Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).
What are the official names of this protein?
Post-GPI attachment to proteins factor 2.
What is the protein family that this protein belongs to?
Belongs to the PGAP2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HSLU_SHESR
Sequence: MSEMTPREIVHELDAHIIGQKKAKRSVAVALRNRWRRMQLDADFRQEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVEQIIRDLTDIAIKLTREQQMGKCRQRAEEHAEERILDALLPKPKNDWDSTDSDANSNTRQIFRKKLREGQLDDKEIDIDVAQPQVGIEIMSPPGMEEMTNQLQSLFKNMGQAPAKRRKMKIKEAFKLLIEEEAAKLVNQEDLKEQAIELVEQHGIVFLDEIDKICKRGETSGPDVSREGVQRDLLPLVEGCTVTTKHGMVKTDHILFIASGAFQMAKPSDLIPELQGRLPIRVELDALSADDFKRILTEPHASLTEQYIALMATEGVTIEFAESGIESIAKAAWQVNERTENIGARRLHTVMEKLMEDISYEASDKSGSSFVIDADYVSAHLDNLVQDEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CO2A1_MOUSE
Sequence: MIRLGAPQSLVLLTLLIAAVLRCQGQDAQEAGSCLQNGQRYKDKDVWKPSSCRICVCDTGNVLCDDIICEDPDCLNPEIPFGECCPICPADLATASGKLGPKGQKGEPGDIRDIIGPRGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPAGPPGPPGPPGLSAGNFAAQMAGGYDEKAGGAQMGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPAGKPGDDGEAGKPGKSGERGLPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGSRGEPGNPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQAGEPGIAGFKGDQGPKGETGPAGPQGAPGPAGEEGKRGARGEPGGAGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLTGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLAGAPGLRGLPGKDGETGAAGPPGPSGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKQGDQGIPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGAAGPDGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPSGSTGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGDQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGANGNPGPAGPPGPAGKDGPKGVRGDSGPPGRAGDPGLQGPAGAPGEKGEPGDDGPSGLDGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGALGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIAGPQGPRGDKGESGEQGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGSNGIPGPIGPPGPRGRSGETGPVGPPGSPGPPGPPGPPGPGIDMSAFAGLGQREKGPDPMQYMRADEADSTLRQHDVEVDATLKSLNNQIESIRSPDGSRKNPARTCQDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNPATVPRKNWWSSKSKEKKHIWFGETMNGGFHFSYGDGNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEMRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGAEQEFGVDIGPVCFL
What is the function of this protein?
Type II collagen is specific for cartilaginous tissues.  It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
What are the official names of this protein?
Collagen alpha-1(II) chain, Alpha-1 type II collagen.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: THIE_HYPNA
Sequence: MTDTAQPRPRTRLYLITPPQIGDVSAFRKSLEETLSAGDVASLQLRLKGQDGMIDMQATQEVGAAVTAMAQEAGVAVLINDAAELSRQLGADGVHLGWDDMPVKTARALLGPDAIIGATAKNSYHRAMQAGEDGADYVAFGAFYPTTTKEGTIPAELELLEVWQSAMILPCVAIGGITVSNAAPLVTAGADFLAVSSGVWNHEDGPAAAVRAFNALFESLA
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: PYRE_STRPD
Sequence: MTLASQIATQLLDIKAIYLKPEDPFTWASGIKSPIYTDNRVTLSYPKTRDLIENGFVETIRAHFPEVEVIAGTATAGIPHGAIIADKMTLPFAYIRSKPKDHGAGNQIEGRVLKGQKMVIIEDLISTGGSVLDAAAAASREGADVLGVVAIFTYELPKASQNFKEAGIKLITLSNYTELIAVAKLQGYITNDGLHLLKKFKEDQVNWQQ
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: MSBA_SACD2
Sequence: MSTPAKPTSVESYKRLLSYAFKYKAYFIISFIGFGVFAAMEAQLINILEYFVDRLEGRPSAPVLGLSADVTSSLWFVPISVVVLSIIRGIGAYFGNFYMSLVGLNVITNLRRQIFSQMIYLPQSFYDTKNSGELISLLVYNIEQVTGSVTNAVKTLFRDGMSVAWFLAMMLIINWKLTLAFICVAPVLGGLMYIASKYFRKVSHKIQSAVGRVSHVATESIQGIKLVKSYGGEKYELDRFNDATNQNLHYGTKFERVSAFQTPVLHIVLALALAVTFYLIMILWDSDSSKAVVYATYAAAIAKPFRQLTKINSIIQKGLAAADTIFEVLDLQAEPNSGQQKLNAPKGRVELKDVHFGYNQDTPALNGISFAIEPGQTVALVGSSGSGKSTIVSLLLRFYDNQQGSITIDGTPIQSLELHNLREHIALVNQQTILFNDTIAANIAYGSEHIDEARIQDAAKQANAHDFIMALPNGYQTPAGEDGSRLSGGQRQRIAIARALYKNAPILILDEATSALDNESEKQIQSALDELKQGRTTLVIAHRLSTIENADTILVMDNGRIVEAGNHQTLLDRSGVYANLYHSQFS
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OBG_ENT38
Sequence: MKFVDEATILVVAGDGGNGCVSFRREKYIPRGGPDGGDGGDGGDVWLEADENLNTLIDYRFEKSFRAERGQNGQSRDCTGKRGKDVTVKVPVGTRVIDQGTGETLGDMTKHGQRLMVGKGGWHGLGNSRFKSSVNRSPRQKTMGTPGDKRDLQLELMLLADVGMLGMPNAGKSTFIRSVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGSDPVENARIIVGELEKYSDKLAAKPRWLVFNKIDLMDKAEAEAKAKAIAEAMGWEDKYYLISAASQMGVKDLCWDVMAFIIENPITQAEEAKQPEKVEFMWDDYHRQQLEEQEVEVEDDEEWDEDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WNT2_MUNMU
Sequence: MNACLVGIWLWLPLLFTWLSPEVSSSWWYMRATSGSSRVMCDNVPGLVSHQRQLCHRHPDVMRAIGLGVTEWTMECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGTAKDNKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGNYLWRKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDRDAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHITRKTKCECKFHWCCAVRCQDCVEALDVHTCKAPKSPDWAAPT
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters (By similarity).
What are the official names of this protein?
Protein Wnt-2.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PROFC_OLEEU
Sequence: MSWQAYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVAERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin-3, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: NNRE_BORPC
Sequence: MDIERVEQVRAVERLAHRRGLALMPRAGLAAADFVAARLPAGAQVLALAGPGNNGGDALVAATLLQARGYRVAVVMPAGPARLPDDARRAWQDWCAAGGQASADLPAHAPALVIDGLFGIGLARPLDGAWQGLIDQVNAWRVPVLALDVPSGLSAASGQPLGDPPGRPVRATWTLSFIGVPAALRAPGAAAWCGEQYLSLLGLTPAFLAEAVGPCGQATATAARRSGP
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: SRRA_STAAR
Sequence: MSNEILIVDDEDRIRRLLKMYLERESFEIHEASNGQEAYELAMENNYACILLDLMLPEMDGIQVATKLREHKQTPIIMLTAKGEETNRVEGFESGADDYIVKPFSPREVVLRVKALLRRTQSTTVEQSEPHARDVIEFKHLEIDNDAHRVLADNQEVNLTPKEYELLIYLAKTPNKVFDREQLLKEVWHYEFYGDLRTVDTHVKRLREKLNRVSSEAAHMIQTVWGVGYKFEVKSNDEPAK
What is the function of this protein?
Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation.  Also plays an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate (By similarity).  Functions as a transcription regulator by direct binding to promoter regions of target genes (By similarity).
What are the official names of this protein?
Transcriptional regulatory protein SrrA, Staphylococcal respiratory response protein A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYPH_BURL3
Sequence: MFLPQEFIRQKRNRQALDRDGIAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALTLAQRDSGDVLDWHALELDGPVIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLSAIPGYNVTPDTDAFRRAVRDVGVAIIGQTARLAPADMRIYAIRDVTATVESVAMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEQSAELARSIVDVGNGAGMKTTAILTDMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLAHDVADARAKLLRALDSGAAAERFARMVTALGGPADLIDAPARHLARAKVVVPVPARASGVVQRVDCRALGLAVVALGGGRTRAADAIDYSVGLTALAEIGQRVEADQPLGYVHARDAAAAAHAVDTIQRSYVLGEAGDAPPTIYQQIG
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: NELFE_MOUSE
Sequence: MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSGPASQGGVKRSLSEQPVVDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSMSADEDLQEPSRRPQRKSLYESFVSSSDRLRELGQDGEEAEAPGAGDGPPRGFDWSYEEHGSARSSASPPRSRSRDRSHDRSRDRDRDKERDRDRDRDRDRDRDKDKDRDRDRDRDKERDRDRDRDRDRERDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDL
What is the function of this protein?
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:31399344).  The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:31399344).  Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity).
What are the official names of this protein?
Negative elongation factor E, NELF-E, RNA-binding protein RD.
What is the protein family that this protein belongs to?
Belongs to the RRM NELF-E family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to chromatin (PubMed:31399344). Phosphorylation by the P-TEFb complex promotes its release from chromatin (PubMed:31399344).