PharMolix/UniProtQA huggingface dataset:
Protein: HEM6_ECO7I
Sequence: MKPDAHLVKQFLLNLQDTICQQLTAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTNAYLPIVERRKTMAYGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALNEFIKVRDWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_LEIME
Sequence: MSAKPQPIAAANWKCNGTTASIEKLVQVFNEHTISHDVQCVVAPTFVHIPLVQAKLRNPKYVISAENAIAKSGAFTGEVSMPILKDIGVHWVILGHSERRTYYGETDEIVAQKVSEACKQGFMVIACIGETLQQREANQTAKVVLSQTSAIAAKLTKDAWNQVVLAYEPVWAIGTGKVATPEQAQEVHLLLRKWVSENIGTDVAAKLRILYGGSVNAANAATLYAKPDINGFLVGGASLKPEFRDIIDATR
What are the official names of this protein?
Triosephosphate isomerase, TIM, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm. Glycosome.
Protein: RECO_MYCA9
Sequence: MRLYRDRAVVLRQHKLGEADRIVTLLTRQHGLVRAVAKGVRRTRSKFGSRLEPFAHIDVQLHPGRNLDIVTQVQAIDAFAADIVSDYGRYTTACAILETAERIAGEERAPAVALHRLTVGALRAIADQQRSRELILDAYLLRAMSIAGWAPAIGECARCATPGPHRAFHVAAGGSVCVHCRPAGAVTPPQGVLELMAALHDGDWAATDDVPQTQRTQASGLIAAHLQWHLERKLRTLPLVERGSRLNMSHGEEQPARSAAG
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: CLAT_PIG
Sequence: MPILEKTPPKMAAKSPSSEEEPGLPKLPVPPLQQTLATYLRCMQHLVPEEQFRRSQAIVQQFGAPGGLGETLQQKLLERQEQTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFQDTNDQLRFAANLISGVLSYKALLDSHSIPIDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQKSSVMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVRMASNEDERLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGMELSDTNRALQLLHGGGCSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMVKSSKKMVRADSVSELPAPRRLRWKCSPEIQGLLASSAEKLQQIVKNLDFTVYKFDDYGKTFIKQQKCSPDAFIQVALQLAFYRLHGRLVPTYESASIRRFHEGRVDNIRSATPEALHFVKAITDHASAMPDSEKLLLLKDAIRAQTQYTVMAITGMAIDNHLLGLRELAREVCKELPEMFTDETYLMSNRFVLSTSQVPTTMEMFCCYGPVVPNGYGACYNPQPESILFCISSFHGCKETSSTKFAKAVEESFIEMKGLCSLSQSGMGKPLATKEKVTRPSQVHQP
What is the function of this protein?
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
What are the official names of this protein?
Choline O-acetyltransferase, CHOACTase, ChAT, Choline acetylase.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
Protein: Y2804_ERWT9
Sequence: MSLTNIMPGYNALASVLTQQGVAMTPAEMHGLISGLICGGSGDRWQTQVHDLTNEGIAWSQTLAQPLQQLHDATSNALEDDGFLFQLYLPEDDDISVFDRADALAGWVNHFLLGLGVTQPKLDKVKGETGEAIDDLRTIAQLGYDEDEDQEELEQSLEEVVEYVRVAALLCHDTFTRVSAPTNVVMKKPTLH
What are the official names of this protein?
UPF0149 protein ETA_28040.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: Y393_SODGM
Sequence: MFRWGIIFLVIALIAAALGFGGLAGTAAWAAKIVFVVGIILFLISLFTGRRGR
What are the official names of this protein?
UPF0391 membrane protein SG0393.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YVDC_VACCC
Sequence: MKILTIEYASSSLRLSNSVHSGLLSIYLFNSSHLNASTNLGSSFCLHADGTPIVLRTKITSLPLIAASI
What are the official names of this protein?
Uncharacterized 7.3 kDa protein.
Protein: MOEA_STAAM
Sequence: MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETKTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
What is the function of this protein?
Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
What are the official names of this protein?
Molybdopterin molybdenumtransferase, MPT Mo-transferase.
What is the protein family that this protein belongs to?
Belongs to the MoeA family.
Protein: TRPA_BACHK
Sequence: MGVERIKAAFENGKKAFIPYVMGGDGGLEILKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQALIEVREEVQIPFVLMTYLNPVLAFGKERFIENCMEAGVDGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTVAGVTGVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICEFIQATKQKEEA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: ABL7_LEPMJ
Sequence: MDTTHDRRTSLSCDECRRRKLKCDRVRPQCGTCALSESECVFPGDSRKRGPKKGQLQALRARIRTLEQQLAAKDATWNMTYDFQDSTAAEPDEFSQCIQPNVNVFEPESMETLIFGIASSTSWPKNGMTPLDPALGAESHDSHISSTLSSLSLSALVQADLEQLFFDRVYQSAPIIHKARYITLMEQEDPLPACVCLRLAIRTSAAAFSARYHDIGERLYLETLQSLESLESNEHTLPWGAKNIQIEHIQSWLLLAVYEHMRMDKSQASSATSRALRLVQRCRLGDLDASDCLIQVGSHTTTATEEDFAVMEEKRRTFWLAFCFDRLLNTRDDLNWALPEEMVGFQHGHSLFSPGHFQGASLMYDLQIRMRVPASEASFQHSQDTNMPLLSEVMGEGNDDSLSPFATCVALMALYGCCATHRRLVSIAGGSGNESTKFWMRHNWLMSAIEKQRRLLQAPESTPNIFGDDPMLAFTHFFVPTLILHLVETADLWQWHSAEQEELRSVYKQQAYIAAKDRTRVAESLLCFSGFKVHPFLPTVLVRFFDFSGKRRIEMSDPDATSESRRNIRAMTKVLSLLRDIHRSAKEIPDDVLDGLETTLL
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of abscisic acid (ABA), a phytohormone that acts antagonistically toward salicylic acid (SA), jasmonic acid (JA) and ethylene (ETH) signaling, to impede plant defense responses.
What are the official names of this protein?
Abscisic acid cluster transcription factor abl7, Abscisic acid biosynthesis cluster protein 7.
What are the subcellular locations of this protein?
Nucleus.
Protein: MRM2_DICDI
Sequence: MLANRANRLVLKRLVHLNTSNIIKPICSYRSLASSSKSKTQFTKKPPISEFSIDEILEHFILKKKTIEGKENKDKNTIKVEKVNTKIDRFSSEVIIKEKNKKNNNIEDEDEFGIEEMIAKNNNNNNNPNNNNNNNNTKKVPTFNRFSTEVIVKSNNNNINEFENEEITKNNLNKKAPKFNRSSSGVVINTTSNDNNNDKNNNEFENEEIMLNSGKTNKKASKMDRYSSEVIIKEKNNEEILVNNNNNNNNNTTTTTNNNNNNKASKMERYSSEVIIKEKKDNNNDIEKDDIEKDEIIVNIMNGFEDKDESAVEFLKRHRIEHQVPKSTIYLKEKTMEEDEMVRKRLSVNRDNINFSNNKNRKQIFTKKNHQNGAGILPKGLANNIVKNDWMKRQMTDPYVAMAQKNDLISRAAYKIINIDEQIQLFKPGQIVVDLGAAPGGWSKYIQERVTNRGLVISVDTSSNFQLDKDCFIHGDFTLTETQNKIFELTKFKSLNDLKLYKHSLIHSDSKIQNLIENGGANGNGSGNGDLQKQPIDNMFKQKSACYVDVVVSDMAPSYSGLQQVDHSRLIDLQRLALFFAFKTLKKGGTFVCKVSRGGEEKKFFKLLESNFISVKSMKPGASRSESTEIYYIGKNYIGK
What is the function of this protein?
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of a 2'-O-methyluridine in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
What are the official names of this protein?
rRNA methyltransferase 2, mitochondrial, rRNA (uridine-2'-O)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ACTL4_HYDVU
Sequence: MLLFKLIVCFFFIFAIGANENKKDETSGENEPSENADVNSEASVVKEAFKKPASRKVNVKPPAAKPPAASKITKPQVPPQKKPPAPKQTTTKKPLLANIEGKIKGAANETTKYLTNLAKEMGKEAESALKEKAKEALTGLLDKADINGAFNAIASIWKNNENKPARYWKCAVENLSEETLVALGTTPYSGNVKTVLSDIPPQSTGVFVWESDSALTGAAGVVHYQLGDKILNIMASDPYDWTLYGAWANVRVSDNKETFDNLYSGKNGAQYPTKAGNWGIADGVKFFLTNNKEAEFQVIFSG
What is the function of this protein?
Pore-forming protein that forms hydrophilic pores and causes cytolysis (PubMed:31513812).  Compared to equinatoxin-2 (AC P61914), it reveals lower cytolysis activity (5-12-fold difference, tested on erythrocytes), a larger pore size (probably 2-3 nm) and different affinity to membrane lipids (100-fold lower affinity to sphingomyelin) (By similarity).  Binds to sulfatides (PubMed:31513812).  Shows cytolytic activity on HeLa cells, with a different potency than its paralogs (from most potent to less potent: HALT-4>HALT-6~HALT-1>HALT-3>HALT-7>HALT-2) (PubMed:31513812).  This recombinant protein has the highest cytolytic activity compared to other rHALT proteins, probably due to its longer N-terminal sequence that may penetrate the lipid bilayer more effectively (PubMed:31513812).  Pore formation is a multi-step process that involves specific recognition of membrane lipid by a protein aromatic residues rich region, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers (By similarity).  In vitro, binds to the folate receptor alpha (FOLR1), a GPI-anchored membrane protein that plays a major role in the uptake of folate/folic acid into cells via endocytosis, suggesting a possible involvement of this receptor in the mechanism of HALT-1-induced cell lysis (By similarity).  In vivo, does not cause visible paralysis in larvae of the blowfly Sarcophaga faculata, the most common arthropod prey of Hydra (By similarity).
What are the official names of this protein?
Hydra actinoporin-like toxin 4, HALT-4, Alpha-pore-forming toxin, alpha-PFT, DELTA-hydritoxin-Hma1d, DELTA-HYTX-Hma1d.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. HALT subfamily.
Protein: PIRL5_ARATH
Sequence: MDSKEMVVEEIMRIHRSLPLRPEIDDVETATSLIQNVEKEDRNRLEAIDKLVKTSSSEVPLELFNVFKEMKKSLVRFQSTEQTREATKILDLESVHVVFDELIQRASFCIASPNSTTALPRSVPVPAPVVSSDEIPFKSKEIISRDDTFVKKAKSSFYSDGLLAPSKPQVLDSTLHQAKNVAGNDGEKLSLIKLASLIEVSAKKATQELNLQHRLMDQLEWLPDSLGKLSSLVRLDLSENCIMVLPATIGGLISLTRLDLHSNRIGQLPESIGDLLNLVNLNLSGNQLSSLPSSFNRLIHLEELDLSSNSLSILPESIGSLVSLKKLDVETNNIEEIPHSISGCSSMEELRADYNRLKALPEAVGKLSTLEILTVRYNNIRQLPTTMSSMANLKELDVSFNELESVPESLCYAKTLVKLNIGNNFANLRSLPGLIGNLEKLEELDMSNNQIRFLPYSFKTLSNLRVLQTEQNPLEELPRDITEKGAQAVVQYMNDLVEARNTKSQRTKPKKSWVNSICFFCKSSTN
What is the function of this protein?
Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.
What are the official names of this protein?
Plant intracellular Ras-group-related LRR protein 5.
What is the protein family that this protein belongs to?
Belongs to the SHOC2 family.
Protein: TRMD_RICPR
Sequence: MSILHVTILTVFPEMFPGTLGYSLAGQALHNNIWSYNIINIRDFGLTKHKNVDDKAYGGGDGLIMRPDVLGNAIENALSLNHNAKIYYPSPRGCVFTQSFAKEMLKNKNLIFLCGRYEGIDERVIAEYNVTEVSVGDYILSGGEIPTLTILDCLIRLLPGVLINQNTLSSESFEKDGEFQGGLECDLYTRPKIWRGRAVPSILLSGNHRLINNWRKEQSHMITKLRRPELLKDL
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H1624_CYRHA
Sequence: MNTVRVTFLLVFVLAVSLGQADKDENRMEMQEKTEQGRSYLDFAENLLLQKLEELEAKLLEEDSEESRNSRQKRCIGEGVPCDENDPRCCSGLVCLKPTLHGIWYKSYYCYKK
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U11-theraphotoxin-Hhn1a, U11-TRTX-Hhn1a, Hainantoxin-XVI.24, NTX-XVI.24, Peptide F4-19.87.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 14 (magi-1) family. 01 (HNTX-16) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TGT_ECO81
Sequence: MKFELDTTDGRARRGRLVFDRGVVETPCFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGNKNALFGIIQGSVYEDLRDISVKGLVDIGFDGYAVGGLAVGEPKADMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKYKSDTGPLDPECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PPME1_CAEEL
Sequence: MSDDKLDTLPDLQSETSHVTTPHRQNDLLRQAVTHGRPPPVPSTSTSGKKREMSELPWSDFFDEKKDANIDGDVFNVYIKGNEGPIFYLLHGGGYSGLTWACFAKELATLISCRVVAPDLRGHGDTKCSDEHDLSKETQIKDIGAIFKNIFGEDDSPVCIVGHSMGGALAIHTLNAKMISSKVAALIVIDVVEGSAMEALGGMVHFLHSRPSSFPSIEKAIHWCLSSGTARNPTAARVSMPSQIREVSEHEYTWRIDLTTTEQYWKGWFEGLSKEFLGCSVPKMLVLAGVDRLDRDLTIGQMQGKFQTCVLPKVGHCVQEDSPQNLADEVGRFACRHRIAQPKFSALASPPDPAILEYRKRHHQ
What is the function of this protein?
Demethylates proteins that have been reversibly carboxymethylated.
What are the official names of this protein?
Probable protein phosphatase methylesterase 1, PME-1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: THIC_DEHM1
Sequence: MTQLKQARKNIITPGMKAIAKIEGLPPEFICQGVADGNIVIPANKLRKNLKLCGIGKGLSTKVNANIGTSTDFGTVESEVEKLKMAEMAGADTIMDLSTGPKINSVRQSILKNTCLPLGTVPVYQAAVEAKDRYGAMVKMTADDLFSAIESQAKEGVDFVTVHCGVTRQVIDTFKGQGRLTDIVSRGGTFTAGWMVFHQAENPLYEHFDHLLDICREYDVTLSLGDGLRPGCIADATDRAQVAELLVLGELVKRAREAEVQVMVEGPGHVPLNQIEANIRLQKSVCEDAPFYVLGPLVTDIAPGYDHITGAIGGAVAAAAGADFLCYVTPAEHLSLPDVTDVRNGVIASRIAAHAADIVKGVNGAAERDRQMAIARKKLDWDSQLNLSLDPEHAKLTRDRFKTKGKACSMCGDFCAMELAEKHLGVSVSRC
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: Y347_HELPY
Sequence: MPFVEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKDLSFFY
What are the official names of this protein?
Uncharacterized RNA pseudouridine synthase HP_0347, RNA pseudouridylate synthase, RNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: USO1_HUMAN
Sequence: MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIGYALDTLYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI
What is the function of this protein?
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane.  May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
What are the official names of this protein?
General vesicular transport factor p115, Protein USO1 homolog, Transcytosis-associated protein, TAP, Vesicle-docking protein.
What is the protein family that this protein belongs to?
Belongs to the VDP/USO1/EDE1 family.
Protein: ILVD_STRAW
Sequence: MPELRSRTVTHGRNMAGARALMRASGVPGADIGRKPIIAVANSFTEFVPGHTHLQPVGRIVSEAITAAGGIAREFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVEAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMESGRATLVDGTVRTLDLVDAISDAVNDKISDEDILRIEENACPTCGSCSGMFTANSMNCLTEAIGLSLPGNGSVLATHTARKGLYEDAARTVVDITRRYYEQDDESVLPRNIATHAAFENAMALDIAMGGSTNTILHLLAAAQEAGVPFGLDEINEVSRRVPCLAKVAPNVAKDRTYYMEDVHRAGGIPALLGELHRAGLLNEDVHSVHSPSLSDWLKTWDVRAGSPSPEAIELWHAAPGCVRSSEAFSQSERWEALDEDAEGGCIRSAEHAYSKDGGLAVLKGNLAVDGCVVKTAGVDESIWTFEGPAVVCESQDEAVDKILRKEITHGDVVVIRYEGPKGGPGMQEMLYPTSFLKGRGLGKTCALITDGRFSGGTSGLSIGHASPEAASGGTIALVQDGDRIRIDIPNRTIDLLVDEAELSRRDQALNGVYAPVNRERKVSAALRAYAAMATSADKGAVRDVSKLG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: NIKR_ECOSM
Sequence: MQRITITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel.
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: RS14Z_CLOBK
Sequence: MARKALIEKWNKTPKHSTRAYTRCRICGRPHAVLKKYGICRICFRELAYKGEIPGCKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: ACEA_GIBZE
Sequence: MASQNMTNPSINPDIEDELFQKEVEAVKTWWSDSRWRQTKRPFTAEQIVSKRGYLPIDYASNTQAKKLWKILEHRFENRDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASASDEPGPDLADYPYTTVPNKVGHLFMAQLFHDRKQRQERLSVPKEQRANLLNIDYLRPIVADADTGHGGLTAVMKLTKLFIEKGAAGIHIEDQAPGTKKCGHMAGKVLVPIQEHINRLVAIRAQADIMGSDLLAIARTDAEAATLLSTNIDPRDHAFILGSTNSTLKPLNDLMIAAEATGKSGAELQRIEDEWLAKANLSSFDDAVAAAIDAGSFSDKAGIKQEYTSRAKGKSNFEARAVARQLLGRDIFFDWDAPRTREGYFRLKGGCDCAVNRAIAYAPYCDAIWMESKLPDFAQAEQFAQGVHAVWPEKKLAYNLSPSFNWKTAMPRDEQETYIRRLAKLGYCWQFITLAGLHTTALISDQFAKAYSTVGMRAYGELVQEPEMDQKVDVVKHQKWSGATYVDELQKMVTGGISSTAAMGAGVTEDQFK
What is the function of this protein?
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle.  Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available.  Acts also on 2-methylisocitrate.
What are the official names of this protein?
Isocitrate lyase, ICL, Isocitrase, Isocitratase, Methylisocitrate lyase, MICA, Threo-D(S)-isocitrate glyoxylate-lyase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
What are the subcellular locations of this protein?
Glyoxysome.
Protein: RLMH_SHISS
Sequence: MKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_ACAM1
Sequence: MTEPGRYKKTVNLPKTKFDMRANAVKREPELQKFWADHQIYENLSQNNPGDVFVLHDGPPYANGDLHIGHALNKILKDTINKFQLLQGRKVRYVPGWDCHGLPIELKVLQNIQPENRAKLTPLKLRWKARDFALKTVEKQSKSFQRYGVWGNWENPYLTLKPEYEAAQIGVFGKMALKGYIYRGFKPVYWSPSSQTALAEAELEYPEGHTSRSIYVTFKVTGLSETAQPLLDEYLPTLKVAIWTTTPWTIPGNLAVSLNPDLTYAVVKAGEDYLIVAEDLVETLTETLESSFKVIKTLPGKALENSTYQHPLFEREGPLVLGDYVTTESGTGLVHTAPGHGQEDYQVGQQYGLAMLSPVDGDGTFTDEAGPFAGLNVLNGGNEAVIEALQSAGALLKEESYAHKYPYDWRTKKPVILRATEQWFASVDGFREAVLDAIATVNWIPAQGENRITSMVSERSDWCISRQRNWGVPIPVFYNDATGEPLLNEATVNHIQGIVAEKGSDAWWELDNDELLPEPYRSDGNTYRKGTDTMDVWFDSGSSWAAVCDQREPLKYPAEMYLEGSDQHRGWFQSSILTSVATNGHAPYKTVLTHGFVLDEQGRKMSKSIGNVVDPAIVIAGGKNQKQDPPYGADVLRLWVSSVDYASDVPLGKNILKQMADVYRKIRNTSRFLLGNLHDFDPAQDAVAYEDLPQLDRYMLHRITEVFTDVTEAFESFQFFRFFQTVQNFCVVDLSNFYLDIAKDRLYISEPNAQRRRSCQTVLAIALENLARAIAPVLSHMAEDIWQSLPYETEHQSVFASGWMRLEDQWHNPDLASHWIVLREIRQEVNKVLEQARTEKEIGSSLEAKVLLYVSDTDLRQQLDAMNPSTGGGSNNVDELRYLFLASQVELLETPKNLDRLMYQFQSETLGVGVVTADGKKCDRCWNYSTYVGRSKQHPLLCDRCEPIIENLVTQGQISLTEEGRYQPNTK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.