PharMolix/UniProtQA huggingface dataset:
Protein: TIG_POLNA
Sequence: MAVTVENLEKLERKMTLTLPLNTIQSEVATRLKKLARTVKMDGFRPGKVPMSVVSQRYAYSVHYEVMNDKVGEAFAVAANEAKLRVAGQPRISEKEDAPEGELAFDAIFEVYPDVKIADLANAEVEKLSAEVSDAAIDKTLDILRKQRRTFALRAADEPAQDGDRVTIDFEGKMDGETFAGGKAEDFQFIVGDGQMLKEFEDAVRGMKSGESKTFPLNFPADYHGKDVAGKQADFLVTVKKIEAAHLPEVNEELAKSLGIADATVEGLRSDIKKNLEREVKFRLLARNKNAVMDALVTNAELDLPNASVQAELERLIENARADLKQRGIKDADKAPIPEELFRPQAEKRVRLGLVVAELVRANELQAKPEQLKSHIEELAASYEKPQEVVRWYLSDNSRMAEVEAVVIENNVTDFVLGKAKVSEKAISFDELMGQN
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: GAL1_ALIFM
Sequence: MTNLIKNVKDAFNSVLSYAPTHILQAPGRVNLIGEHTDYNDGFVLPCAINYQTVVAAAKRDDNIVRVVSVDYGNETDEFDITQEITFQENKMWSNYIRGVVKCLIGRGYEFKGADISVSGNVPQGAGLSSSAALEVVIGQTFKELYNLDISQAEIALNGQQAENEFVGCNCGIMDQMISAEGNENHAMLLDCRSLETTAVSMPEDMSVVIINSNKKRGLVDSEYNTRREQCEEAARIFGVKALRDVTIEEFNAKAHELDEMVAKRARHVITENDRTEEAAKVLASGDMKRMAVLMAESHASMRDDFEITVSEVDTLVDIVKNVIGAEGGVRMTGGGFGGCIVALVPPMLVDEVKAAVEELYEAKTGLKESIYVCQATNGAGLVL
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAE1_ARTBC
Sequence: MVTLPLLLSILPLAAVFSSAASLQVRENHDCASIQPPQVPGAEILSVIGVQRRVEVAPFPPSPSKPNTTIDICSVNVTLSHMGVNDKVVVSVWLPLPDKWNGRFQATGGGGWAAGTFDLLMGPAALEGYSTAGTDAGVTVDPGSADKWALKEDGTVNYDLLENFASRSIHDMAIVGKAVTESYYKKPANYSYFYGCSNGGRQGMVEAQKYPDDFDGILAGAPAIYWPQFLTSTEWPQVVMQSEKVFPSQCVFEAFRKAGIAACDKLDGVEDGVVSNLDGCEFNPFALVGKKVKCGEESTTITLAQAWVAKKIYDGPKSTAKHALWDVLPVGASYVGLANSTIENGVPKIAPFVIGSSWIRSFLKKDVNFDLSTITYADMPKLFQQSIDEFDKIAGGSNPDLSALKKSGTKLLSWHGLADELIHPQGSIKYRQAVEHRMGGGSEVDNYYRLFLAPGVTHCGIGVNDGAAPIDTLKVLVRWVEKGEAPETMPATATDASGTTTLFTRNLCRYPLVPRYKGGDKNSADSFECAKDFGSHH
What is the function of this protein?
Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds.
What are the official names of this protein?
Probable feruloyl esterase ARB_07085.
What is the protein family that this protein belongs to?
Belongs to the tannase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RUVA_RICTY
Sequence: MIGKLSGKIDSQCDDYVIIDVNGVGYLVYASGTTLAKLVEGRFYKLFIETHVREEHIHLYGFLTLEEKNFFNLLQSVNGIGTKMALSILSNLTPTDIKIAINNDDKNIFKAISGVGDKLTERIMLELKGKIAKIFSSSAIIKDSSNISSVEINEVIKALVNLGFTRFEAQNTVQGIITQNTKISIDELIKTALKNRNSSF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RS20_PSEMY
Sequence: MANSPSAKKRAKQAEKRRSHNASLRSMVRTYIKNVVKAIAAKDLELAKTAYTAAVPVIDRMADKGIIHKNKAARHKSRLNAHIKALGEAAAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: CYSE_STAAN
Sequence: MLKRMRDDIKMVFEQDPAARSTLEVITTYAGLHAVWSHLIAHKLYNQKKYVAARAISQISRFFTGIEIHPGAKIGKRLFIDHGMGVVIGETCTIGDNVTIYQGVTLGGTGKERGKRHPDIGDNVLIAAGAKVLGNIKINSNVNIGANSVVLQSVPSYSTVVGIPGHIVKQDGVRVGKTFDHRHLPDPIYEQIKHLERQLEKTRNGEIQDDYII
What are the official names of this protein?
Serine acetyltransferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y496_LARHH
Sequence: MLLHIPHVLTREQVRACRARLDAADWADGRITAGSQSAQVKRNLQLPQSSPVAQELSAQVEQTLRQHPLFFSAALPKRFFPPLFNRYEGGMNFGNHVDNALRYLPGTTDAVRTDVSATLFLSDPDEYDGGELVVEDTYGVHSVKLPAGDIVVYPSTSLHRVEPVSRGARVASFMWIQSLVREDARRTLLFDMDMNIQRLRERHGDTEELVGLTSAYHNLLRLWAEV
What are the official names of this protein?
PKHD-type hydroxylase LHK_00496.
Protein: RHLB_HAES1
Sequence: MQNSHLSQQRFSDLALHRSVQQAIKEKGFEFCTPIQALSLPITLKGQDIAGQAQTGTGKTIAFLTATFHHLLQKNNINSSEQPRALILAPTRELVVQIANDANFLVQATGLKTGLAYGGEGYDKQLKVIDQGIDILIGTTGRVIDYVKQGIIRLDYIQVVVLDEADRMFDLGFIRDIRYLLRKCPVPQQRLTMLFSATLSYKVRELAFEHMNDPQYVEIEPLQKTGHRIREELFYPSNQDKMALLMTLLEEEWPERCIIFSNTKHRCEEIWGYLSADGHRVGLLTGDVMQKKRLSLLKQFTDGTLDILVATDVAARGLHIPDVTHVFNYDLPDDCEDYVHRIGRTGRAGESGISISFACEEYAINLPAIEEYIGHSIPVSQYDAKALIEDLPTPHRIKRGAFDSRSNLQRTIKRLKKTY
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR2W3_HUMAN
Sequence: MDGTNGSTQTHFILLGFSDRPHLERILFVVILIAYLLTLVGNTTIILVSRLDPHLHTPMYFFLAHLSFLDLSFTTSSIPQLLYNLNGCDKTISYMGCAIQLFLFLGLGGVECLLLAVMAYDRCVAICKPLHYMVIMNPRLCRGLVSVTWGCGVANSLAMSPVTLRLPRCGHHEVDHFLREMPALIRMACVSTVAIEGTVFVLAVGVVLSPLVFILLSYSYIVRAVLQIRSASGRQKAFGTCGSHLTVVSLFYGNIIYMYMQPGASSSQDQGMFLMLFYNIVTPLLNPLIYTLRNREVKGALGRLLLGKRELGKE
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2W3, Olfactory receptor 2W8, Olfactory receptor OR1-49.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYE1_THEMA
Sequence: MVRVRFAPSPTGFLHVGGARTALFNFLFARKEKGKFILRIEDTDLERSEREYEEKLMESLRWLGLLWDEGPDVGGDHGPYRQSERVEIYREHAERLVKEGKAYYVYAYPEEIEEMREKLLSEGKAPHYSQEMFEKFDTPERRREYEEKGLRPAVFFKMPRKDYVLNDVVKGEVVFKTGAIGDFVIMRSNGLPTYNFACVVDDMLMEITHVIRGDDHLSNTLRQLALYEAFEKAPPVFAHVSTILGPDGKKLSKRHGATSVEAFRDMGYLPEALVNYLALLGWSHPEGKELLTLEELISSFSLDRLSPNPAIFDPQKLKWMNGYYLRNMPIEKLAELAKPFFEKAGIKIIDEEYFKKVLEITKERVEVLSEFPEESRFFFEDPAPVEIPEEMKEVFSQLKEELQNVRWTMEEITPVFKKVLKQHGVKPKEFYMTLRRVLTGREEGPELVNIIPLLGKEIFLRRIERSLGG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAS5D_THET2
Sequence: MARLKVKVWGEYACFSRPEFKVERVSYPVPTPSAARGLLEAIFWKPEFRYEVRRIGVLRLGTPFALLRNEVGNRMGAKPFFVEDARQQRTSLVLKDVAYLVEADMVLRPHATDPLPKYLEQFERRLKKGQYHHTPYLGTREFPAYFSPPDGEVPDGGLNLDLGPMLFDLAFVEDPGRPELTFKRPGRGEVQGYALPLFFHARIREGWLEVPAEKYQELYRLEEGHAKGA
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  This protein is a sequence-specific endonuclease that cleaves pre-crRNA into mature crRNA, possibly by an intramolecular attack of the 2'-hydroxyl group of G26 on the scissile phosphodiester, cutting the precursor 3' to G26 residue yielding 5'-hydroxyl and 2' and/or 3' ends lacking a hydroxyl group (perhaps a 2'/3' cyclic phosphodiester).  Requires between 4 and 8 nt downstream of the cleavage site for both binding and cleavage of pre-crRNA.  Substitution with dG at this position abolishes cleavage but not RNA binding.  Does not cleave pre-crRNA associated with the M. succiniciproducens strain MBEL55E Cas5 protein (AC Q65TW5) CRISPR locus.
What are the official names of this protein?
CRISPR pre-crRNA endoribonuclease Cas5d, Pre-crRNA processing endonuclease Cas5d.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
Protein: CAPR1_MOUSE
Sequence: MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDDVRTDLKQGLSGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKALKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPTVEDQVAEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFSSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQSDPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPQVHSESRLAQSNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPMDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPANEPETLKQQSQYQATYNQSFSSQPHQVEQTELQQDQLQTVVGTYHGSQDQPHQVPGNHQQPPQQNTGFPRSSQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRPSFSNTPNSGYSQSQFTAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN
What is the function of this protein?
mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:20516077).  Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity).  Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity).  In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity).  Binds directly and selectively to MYC and CCND2 mRNAs (By similarity).  In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity).
What are the official names of this protein?
Caprin-1, Cytoplasmic activation- and proliferation-associated protein 1, GPI-anchored membrane protein 1, GPI-anchored protein p137, GPI-p137, p137GPI, Membrane component chromosome 11 surface marker 1, RNA granule protein 105.
What is the protein family that this protein belongs to?
Belongs to the caprin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell projection, dendrite. Cell projection, lamellipodium. Note=Associated with RNA granules (PubMed:17210633). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity).
Protein: CX066_BOVIN
Sequence: MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTHAEFKQTKLQELRRRLLIIVIGTLITGYMVSCTCLLHYSCDSEEAHTAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKPVSQVSPSYPEKAIKSTWPPSLQCRAKPTKTPLPYPKNQSFPEQSSVDKLTKRQRYLKLKCPASAGRAEILSRPHPVKFCRCYKEKCLVCRAVSEPFITHVSDANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSRNN
What are the official names of this protein?
Uncharacterized protein CXorf66 homolog.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: Y757_DEHMC
Sequence: MAYNRKETGEFGEKLAAEYLKGMGYSIIQTNCRLPEGEIDIVGQDGEYLVFIEVRTKRRLGYGLPAESVTPRKKAHLMASAESYIQKHRLEHFPCRIDFVSVDLSQPEPRLELIKNALGEE
What are the official names of this protein?
UPF0102 protein cbdbA757.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: MAB5_CAEEL
Sequence: MSMYPGWTGDDSYWAGAGTTASSQSASSGTSASASSSAAAAAAANNLKTYELYNHTYMNNMKHMLAAGWMDNSSNPFAYNPLQATSANFGETRTSMPAISQPVFPWMKMGGAKGGESKRTRQTYSRSQTLELEKEFHYHKYLTRKRRQEISETLHLTERQVKIWFQNRRMKHKKEAKGEGGSNESDEESNQDEQNEQHSS
What is the function of this protein?
Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration (PubMed:8898225, PubMed:23784779).  During postembryonic development, required for posterior-specific pattern formation (PubMed:2903796).  Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation (PubMed:2903796, PubMed:21307099).
What are the official names of this protein?
Homeobox protein mab-5, Protein male abnormal 5.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VIRB8_AGRFC
Sequence: MKGSEYALLVARETLAEHYKEVEAFQTARAKSARRLSKVIAAVATIAVLGNVAQAFTIATMVPLIRLVPVYLWIRPDGTVDSEVSVSRLPATQEEAVVNASLWEYVRLRESYDADTAQYAYDLVSNFSAPMVRQNYQQFFNYPNPTSPQVILGKHGRLEVEHIASNDVTPGVQQIRYKRTLIVDGKMPMASTWTATVRYEKVTSLPGRLRLTNPGGLVVTSYQTSEDTVSNAGHSEP
What is the function of this protein?
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
What are the official names of this protein?
Protein virB8.
What is the protein family that this protein belongs to?
Belongs to the virB8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: G3P1_STAEQ
Sequence: MAIKVAINGFGRIGRLAFRRIQDVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVIEGGFRVNGKEIKSFDEPDAGKLPWGDLDIDVVLECTGFYTDKEKAQAHIDAGAKKVLISAPAKGDVKTIVFNTNHDTLDGSETVVSGASCTTNSLAPVAKVLSDEFGLVEGFMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLDKQDVTVDQVNSAMKQASDESFGYTEDEIVSSDIVGMTYGSLFDATQTRVMTVGDRQLVKVAAWYDNEMSYTAQLVRTLAHLAELSK
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 1, GAPDH 1, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYCP_ALCXX
Sequence: QFAKPEDAVKYRQSALTLMASHFGRMTPVVKGQAPYDAAQIKANVEVLKTLSALPWAAFGPGTEGGDARPEIWSDAASFKQKQQAFQDNIVKLSAAADAGDLDKLRAAFGDVGASCKACHDAYRKKK
What is the function of this protein?
Cytochrome c' is the most widely occurring bacterial c-type cytochrome.  Cytochromes c' are high-spin proteins and the heme has no sixth ligand.  Their exact function is not known.
What are the official names of this protein?
Cytochrome c'.
What are the subcellular locations of this protein?
Periplasm.
Protein: DTBP1_RAT
Sequence: MLETLRERLLSVQQDFTSGLKTLSDKSKEAKVKSRPRTAPYLPKYSAGLDLLSRYEDTWAALHRRAKECADAGELVDSEVVMLSAHWEKKRTSLAELQEQLQQLPALLQDVESLMASLAHLETSFEEVENHLLHLEDLCGQCELERHKQAHARHLEDYKKSKRKELEAFKAELDTEHAQKILEMEHTQQLKLKERQKFFEEAFQQDMEQYLSTGHLQIAERREPMGSMSSMEVNVDVLEQMDLMDLSDQEALDVFLNSGGEDNTVISPGLEMESNPSQNEMNLQIPNPSESASQPPASPSACTDLDTADAPLIQADEEEVQVDTALVTLNTDRKSTPGVSDDSDQCDSTQDI
What is the function of this protein?
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes.  In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.  The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension.  Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function.  Plays a role in synaptic vesicle trafficking and in neurotransmitter release.  Plays a role in the regulation of cell surface exposure of DRD2.  May play a role in actin cytoskeleton reorganization and neurite outgrowth.  May modulate MAPK8 phosphorylation.  Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release.  Regulates the expression of SYN1 through binding to its promoter.  Modulates prefrontal cortical activity via the dopamine/D2 pathway.
What are the official names of this protein?
Dysbindin, Biogenesis of lysosome-related organelles complex 1 subunit 8, BLOC-1 subunit 8, Dysbindin-1, Dystrobrevin-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the dysbindin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Melanosome membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Postsynaptic density. Presynaptic cell membrane. Endoplasmic reticulum. Note=Mainly cytoplasmic but shuttles between the cytoplasm and nucleus. Exported out of the nucleus via its NES in a XPO1-dependent manner. Nuclear localization is required for regulation of the expression of genes such as SYN1 (By similarity). Detected in neuron cell bodies, axons and dendrites. Detected at synapses, at postsynaptic density, at presynaptic vesicle membranes and microtubules. Associated with the AP- 3 complex at presynaptic terminals. Detected at tubulovesicular elements in the vicinity of the Golgi apparatus and of melanosomes. Occasionally detected at the membrane of pigmented melanosomes in cultured melanoma cells (By similarity). The BLOC-1 complex associates with the BLOC-2 complex in early endosome-associated tubules. Associated with the AP-3 complex at presynaptic terminals.
Protein: SIPL4_ARATH
Sequence: MILWKSLSCFSFVFGLLLYSASFVCAGDIVHHDDSLPQRPGCNNNFVLVKVPTRVNGSEYTEYVGVGARFGPTLESKEKHATLIKLAIADPPDCCSTPKNKLTGEVILVHRGKCSFTTKTKVAEAAGASAILIINNSTDLFKMVCEKGENVLDITIPVVMLPVDAGRSLENIVKSNAIVTLQLYSPKRPAVDVAEVFLWLMAVGTILCASYWSAWTVREEAIEQDKLLKDGSDELLQLSTTSSRGVVEVTVISAILFVVVASCFLIMLYKLMSFWFIEVLVVLFCIGGVEGLQTCLVSLLSCFRWFRRFGESYVKVPFLGAVSYLTLAICPFCIAFAVFWAVKRQYSYAWIGQDILGISLIITVLQIVRVPNLKVGFVLLSCAFMYDIFWVFVSKWWFRESVMIVVARGDRSGEDGIPMLLKIPRMFDPWGGYSIIGFGDIILPGLLVTFALRYDWLANKRLKSGYFLGTMSAYGLGLLITYIALNLMDGHGQPALLYIVPFILGTLFVLGHKRGDLKTLWTTGEPDRPCPHVRLQPQSS
What is the function of this protein?
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.
What are the official names of this protein?
Signal peptide peptidase-like 4, AtSPPL4.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22B family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein.
Protein: RENT2_ARATH
Sequence: MDHPEDESHSEKQDDEEALARLEEIKKSIEAKLTLRQNNLNPERPDSAYLRTLDSSIKRNTAVIKKLKQINEEQREGLMDDLRGVNLSKFVSEAVTAICEAKLKSSDIQAAVQICSLLHQRYKEFSASLTQGLLKVFFPGKSAEDLEADKNSKAMKKRSTLKLLLELYYVGVIEDSNIFINIIKDLTSVEQLKDRDTTQTNLTLLTSFARQGRIFLGLPISGQDEDFFKGLDVTADQKKSFKKAFNTYYDALADLLQSEHKLLLQMEKENAKLVNAKGELSEDSASSYEKLRKSYDHLYRNISSLAEALDMQPPVMPEDGTTRLTAGDEASPSGTVKDTSVPEPIWDDEDTKTFYECLPDLRAFVPAVLLGEAEPKSNEQSAKAKEKLSESSSEVVENQQTTEDTTEVSADSASMDDRSNAEQPKEKEEVEKEKAKDTKKEKGKEKDSEKKMEHEKEKGKSLDVANFERLLQRLPGCVSRDLIDQLTVEYCYLNSKTNRKKLVKALFNVPRTSLELLAYYSRMVATLASCMKDIPSMLVQMLEDEFNSLVHKKDQMNIETKIRNIRFIGELCKFKIVPAGLVFSCLKACLDEFTHHNIDVACNLLETCGRFLYRSPETTLRMTNMLDILMRLKNVKNLDPRQSTLVENAYYLCKPPERSARISKVRPPLHQYVRKLLFSDLDKDSIANVLKQLRKLPWSECEQYILKCFMKVHKGKYGQIHLIASLTSGLSRHHDEFVVAVVDEVLEEIRVGLELNEYGAQQKRLAHMRFLGELYNYEHVDSSVIFETLYLTLLYGHDTSEQEVLDPPEDFFRVRMVIILLETCGHYFDRGSSKKRLDQFLIHFQRYILSKGHLPLDIEFDLQDLFANLRPNMTRYSTIDEVNAAILQLEEREHASSGDKVSIERHSDTKPSNKSSSDVISSNGKSTAKDIRENGEAHGEESDSDSGSGSVVRDGQNEELDDGNHERGSESGDGDDYDDGDGPGSDDDKFRVRQKVVTVDLEEQADFDQELKALLQESMEQRKLELRGRPALNMTIPMSVFEGSGKDHHHFGRVVGENGEEVLDEENGEQREVQVKVLVKRGNKQQTRQMLIPSDCALVQSTKQKEAAELEEKQDIKRLVLEYNERDEEEANGLGTQILNWTSGGSRGSTRTGEGSGKSGGSRHRFYYHQGGGGSYHARRK
What is the function of this protein?
Recruited by UPF3 associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD.  In cooperation with UPF3 stimulates both ATPase and RNA helicase activities of UPF1.  Binds spliced mRNA (By similarity).  Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC).  Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding.
What are the official names of this protein?
Regulator of nonsense transcripts UPF2, Nonsense mRNA reducing factor UPF2, Up-frameshift suppressor 2 homolog, AtUpf2.
What is the protein family that this protein belongs to?
Belongs to the RENT2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Cytoplasm, perinuclear region.
Protein: CYOE_SALPA
Sequence: MMFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPGVSLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGDFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLTLGGYAGYKYLVVAAAVSVWWLGMALRGYKVEDDKVWARKLFGFSIIAITALSIMMSVDFMVPNSQNLLTYVW
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.