PharMolix/UniProtQA huggingface dataset:
Protein: CP2DF_CANLF
Sequence: MGLLTGDTLGPLAVAVAIFLLLVDLMHRRRRWATRYPPGPTPVPMVGNLLQMDFQEPICYFSQLQGRFGNVFSLELAWTPVVVLNGLEAVREALVHRSEDTADRPPMPIYDHLGLGPESQGLFLARYGRAWREQRRFSLSTLRNFGLGRKSLEQWVTEEASCLCAAFAEQAGRPFGPGALLNKAVSNVISSLTYGRRFEYDDPRLLQLLELTQQALKQDSGFLREALNSIPVLLHIPGLASKVFSAQKAIITLTNEMIQEHRKTRDPTQPPRHLIDAFVDEIEKAKGNPKTSFNEENLCMVTSDLFIAGMVSTSITLTWALLLMILHPDVQRRVQQEIDEVIGREQLPEMGDQTRMPFTVAVIHEVQRFGDIVPLGVPHMTSRDTEVQGFLIPKGTTLITNLSSVLKDEKVWKKPFRFYPEHFLDAQGHFVKHEAFMPFSAGRRVCLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSDHGVFTFLKVPAPFQLCVEPR
What is the function of this protein?
High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.
What are the official names of this protein?
Cytochrome P450 2D15, CYPIID15, Cytochrome P450 DUT2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: YOE7_SCHPO
Sequence: MGSAESKISFRHAILASLNTKPEREIYEFLFTCNLTENDVFSFILAQDIRICRDSNKFDNLAILLQVCVLNIVSIQNKFSEQYPLKKNALLNSFLILTRLLPYLYESTNSSNWVRTYFQKDFSQTVDDLKPLLSELGLNYEIELPNSFSNLTSLLSSTFQLCFQHEFTVSKYASSEESIWSAGIAIPEIAHPPSYDHRLHQSLLSCFLVVLLSNTLYDSIDELDFSVLNSIVSLDAKDIYIRVICSFVNTGFIDSTNWFLNSFNQRRNSLQLYSSWFIILILSDARIKENTHLYANGEGQHIKNHLLELFKKLHRTQDFLIIAESINKFLSNPLKKERQIITFMGDFKRCVVESLCFLFLLLTNQPRFTDELVNFKSSNEMMMNLLFIHVKYSGDTENSYMSSLAGYCLQQLVSHEKLVKAACHIDKSLISPSPSSQFPVFDTSVAIYVIQVLCTLENPSSIEYNIISNILFSIPTIPLKNASPIVELISYVMKPEFFMKSQQNASDCKKLLSSFLYFLINNFNDNLHIIELLQKDKRKFEPIIAWSETEFSEFFVTSNISQSALDNGLVDQAGLDEQKWYEKWFHDLNIPLLRKCLTLRTDKNPFIEQPDEPNVTKKIYRVTYTDALQRWNLVNIWRHIFKETVTLNSGISCPWYGTNVKLFTVREVRQPTILQSRSLGEFQGRLFS
What are the official names of this protein?
Hid-1 family protein P19A11.07c, Down-regulated in multiple cancers 1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the hid-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: OBG_POLNS
Sequence: MKFIDEARIEVIAGQGGAGSASMRREKFIEFGGPDGGDGGKGGSVWATADRNINTLIDYRYAKTHTAKNGEPGRGADCYGRAGDDIELRMPVGTIISDYETGEPIADLTTHGERLCLAQGGVGGWGNIHFKSSTNRAPRQKTNGKSGERRKLKLELKVLADVGLLGMPNAGKSTLITAVSNARPKIADYPFTTLHPNLGVVRVGSERSFVIADIPGLIEGAAEGAGLGHRFLRHLQRTGVLLHLVDIAPFDANVDPVADAAAIVNELRKYDEALVEKPRWLVLNKVDIIPEEGRKKVVSDFVKKFKWKGPVFEISALTGMGCDKLCYSLQDYLDSIRRDRDDAGERAQDPRYQDQPEDKNQIKYFTCALL
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_STRA3
Sequence: MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVVGDNKSQLVKSVGRIAELQAKVGDSVSGTTGIGHTRWATHGKPTEGNAHPHTSGSGRFVLVHNGVIENYLQIKETYLTKHNLKGETDTEIAIHLVEHFVEEDNLSVLEAFKKALHIIEGSYAFALIDSQDADTIYVAKNKSPLLIGLGNGYNMVCSDAMAMIRETSEYMEIHDKELVIVKKDSVEVQDYDGNVIERGSYTAELDLSDIGKGTYPFYMLKEIDEQPTVMRKLISTYANESGDMNVDSDIIKSVQEADRLYILAAGTSYHAGFAAKTMIEKLTDTPVELGVSSEWGYNMPLLSKKPMFILLSQSGETADSRQVLVKANEMGIPSLTITNVPGSTLSREATYTMLIHAGPEIAVASTKAYTAQVATLAFLAKAVGEANGKAEAKDFDLVHELSIVAQSIEATLSEKDVISEKVEQLLISTRNAFYIGRGNDYYVTMEAALKLKEISYIQTEGFAAGELKHGTISLIEDNTPVIALISADSTIAAHTRGNIQEVVSRGANALIIVEEGLEREGDDIIVNKVHPFLSAISMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_STAAW
Sequence: MRTYEVMYIVRPNIEEDAKKALVERFNGILATEGAEVLEAKDWGKRRLAYEINDFKDGFYNIVRVKSDNNKATDEFQRLAKISDDIIRYMVIREDEDK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: OSMO_TOBAC
Sequence: MGNLRSSFVFFLLALVTYTYAATIEVRNNCPYTVWAASTPIGGGRRLDRGQTWVINAPRGTKMARVWGRTNCNFNAAGRGTCQTGDCGGVLQCTGWGKPPNTLAEYALDQFSGLDFWDISLVDGFNIPMTFAPTNPSGGKCHAIHCTANINGECPRELRVPGGCNNPCTTFGGQQYCCTQGPCGPTFFSKFFKQRCPDAYSYPQDDPTSTFTCPGGSTNYRVIFCPNGQAHPNFPLEMPGSDEVAK
What are the official names of this protein?
Osmotin.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
What are the subcellular locations of this protein?
Vacuole. Note=Vacuolar inclusion body.
Protein: GVPK1_HALSA
Sequence: MELALDDDADDLQGGLTALVVTVVELLVEALEQEAVRRMESGSLSEDEIERLGRQLQALEDELERLKQQEDINAEVSEFREDLDHVIRDAIEQLSEHETPSGHGSPESQRDDV
What is the function of this protein?
May play a structural or regulatory role in gas vesicle synthesis.
What are the official names of this protein?
Protein GvpK 1.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: PIG1_DROME
Sequence: MKLTKLWLLFVCLGLFVTLVVSADTDSDADSDSSADSDSSADSDENTTASGSIVTSTTESSATNSSGSSDDASGSSSDVDDGSDDDTDSGSDTDYDTPTTAPVVKKRANRKKANNNKKRASNNRKKANNNNNNKKRANSNNNRKRRASNNNNKKKASNNNNRRRNNNSRRRG
What are the official names of this protein?
Pre-intermoult gene 1 protein, Gland-specific protein.
Protein: PSTS1_MYCBP
Sequence: MKIRLHTLLAVLTAAPLLLAAAGCGSKPPSGSPETGAGAGTVATTPASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNIGASDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKTWDDPQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVDFPAVPGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLPDAQSIQAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQAFLHWAITDGNKASFLDQAHFQPLPPAVVKLSDALIATISS
What is the function of this protein?
A host TLR2 agonist (toll-like receptor), requires both host TLR1 and TLR2 as coreceptors.
What are the official names of this protein?
Phosphate-binding protein PstS1, PstS-1, 38-kDa lipoprotein, P38.
What is the protein family that this protein belongs to?
Belongs to the PstS family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Secreted. Note=Present on the cell surface.
Protein: FABH_LACLM
Sequence: MTFAKITQAAHYVPENVVSNDDLSKIMDTNDEWIYSRTGIKNRHISTGENTSDLATKVAKQLIENSGVDPELIDFIIVATVTPDSMMPSTAARVQAQVGATNAFAYDLTAACSGFVFALSTAEKLISSGAYQRGIVIGAEVFSKVIDWSDRSTAVLFGDGAAGVLLDNSGSQPLIIAEKMQTDGKRGGSLLSSYADIQTPFASVSYEGSNLSMEGRAIFDFAVRDVPKNIQATLEKSDLAAEEIDYYLLHQANSRILDKMAKKLGVTRDKFLQNMQEYGNTSAASIPILLSESVKNGIFSLDGQTKVVLTGFGGGLTWGTAIINL
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_ECOLU
Sequence: MPVITLPDGSQRHYDHAVSPMDVALDIGPGLAKACIAGRVNGELVDACDLIENDAQLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVIDNGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARETFANRGESYKVSILDENIAHDDKPGLYFHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2R13_PONPY
Sequence: MESALPSILTLVIIAEFIIGNLSNGFIVLINYIDWVSKRELSSVDKLLIILAISRIGLIWEILVSWFLALHYLAIFVSGTGLRIMIFSWIVSNHFSLWLATILSIFYLLKIASFSSPAFLYLKWRVNKVILMILLGSLVFLFLNLIQINIHIKDWLDRYEGNTTWNFSMSDFVTFSVSVKFTMTMFSLTPFTVALISFSLLIFSLQKHLQKMQLNYKGHREPRTKVHTNALKIVISFLLLYASFFLCILISWISELYQNTAIYMLCETIGLFYPSSHSFLLILGNPKLRQAFLLVAAKVWAKR
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 13, T2R13.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PB1F2_I72A3
Sequence: MEQEQDTPWTQSTEHINIQKKGSGQQTQRLGRPNLTQLMDHYLRIMSQVDMHKQTVSWKQWPSLKNPTQGSLKTRALKRWKSFNKQGWTN
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: ACEK_XANCB
Sequence: MNQQPLPPQSERRALAIGRAVYEAFQDYHAQFSQITARARQRFETRDWSGAREDAVARIALYDHYISECMLRLRAVLLGQAHDRALWMRARTHYAELLTGLIDQELYKTFYNTLTRRYFRTQGVDAQIEFIALDIEPTDAITVPVARHTYAVSPGRLTEMLVRVLGDYPFEVPYAHRTRCAAAIAVRLLDDLAHWGEHPVRSVELLETVFYRERRAYLVGRLFGEHRFSPCVIALVNDDAGLRAEAVLTRRSDVAQLFSNSRSYFQADLTTVGDAVVFLRSLLTHKPIDELYTMLGRAKQGKTERYRTFFRHFQAHPAEQLVHADGTPGMVMVVFTLPSYPLVFKLIRDRFAYPKTMSRAQVEGKYELVFQLDRIGRLLDAQPYRFLRFPKARFSPALLQDLQSSCAMSLSEDGDDVLIALCYVQRRLRPLNLYLREQLPAAAHAAALDYGQAIKDMARNNIFPGDMLLKNFGITRHQRAVFYDYDELCLITECTFRDWPTPTSYEEQMAAEPWFHVGPRDVFPERFALFMGLPSSQLEAVKHMHPELFDPQWWRDLQARLREDDYPDTPPYADAQKLA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_NOSP7
Sequence: MSSLLQGVNLYLIGMMGVGKTTVGPLLAKHLGYGFLDLDGVIAKATDKSINQLFAEEGEAGFRQIESDVLSQVCAFTKLTIATGGGIVLRRENWGYLHHGLIVWLDVPVELIYRRLAEDTTRPLLQDADLKGKLRSLLEQRTPLYSQADLHITVQEGETPEDIANRIIEVIPNVLKPQASH
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DVR1_DANRE
Sequence: MFLVLLRACLLTLSLCSPAEDDGLVQEKLFLSSMGLWSRPKPSHHAAVPSQMWKIFKQASKQTVNDPCVVSEYGVRGNIVRFMQDQGSLISAPAVHSFNCVRKHLFFNMSVLEEVEQLSLAQLEMKFKQDLLLLGPHVFSVDLYRVLKTTLKGVTHESSRKLLQSQTLSPGAHASVLVNLTNLAQSWRKPEKNFGMQLELQVMHLNNMLHDHAYVQIPDIHATLVVVSLNPLQCRSRRKRSASYYLPVTPSNVCKPRRLYIDFKDVGWQDWIIAPQGYLANYCHGECPFPLSESLNGTNHAILQTLVHSFDPKGTPQPCCVPIKLSPISMLYYDNNDNVVLRHYEDMVVDECGCR
What is the function of this protein?
Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.
What are the official names of this protein?
Protein DVR-1.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: D2HDH_BOVIN
Sequence: MMMPRLVPRWPAWLFCWRAACIQGASVRQKMWAGPSKIPGLGGPRGAWGTSPLVPRGSCSASSRTPEVTLTPERYPVQRLPFSVVSEDDLAALERVVPGRVITDPEELEPPNVDWLRTVRGSSKVLLRPRTTQEVAHILRYCHERNLAVNPQGGNTGMVGGSTPVFDEIILSTALMNQVLSFHDVSGVLVCQAGCVLEALSQYVEERGFIMPLDLGAKGSCHIGGNVATNAGGLRVLRYGSLRGTVLGLEVVLADGTVLNCLTSLRKDNTGYDLKQLFIGSEGTLGVITAVSILCPPKPSTVNVAFLGCPGFAEVLQTFRTCRAMLGEILSAFEFMDAECMKLVRLHLGLSCPVQESPFYVLIETAGSGPGHDAEKLGCFLEQVLDSGLVTDGTLGSDERRIKMLWALRERITEALSRDGYVYKYDLSLPLDRLYDLVGDLRARLGPSAKHVVGYGHLGDGNLHLNVTSEAFSTSLLGALEPYVYEWTAGQRGSVSAEHGLGFKKKDVLGYSKPPEALQLMRQLKALLDPKGILNPYKMLPTHA
What is the function of this protein?
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (By similarity).  Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (By similarity).  Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity).
What are the official names of this protein?
D-2-hydroxyglutarate dehydrogenase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TRUA_LISMC
Sequence: MTRYKAIISYDGSGFYGYQVQPNTRTVQAEIEKALTKMHKGKTVRITASGRTDTGVHAKGQVIHFDSELDITAEKFQKALQVMTPFDISFLTVEEVPDDFHARFGTVGKEYRYVVKRTKIFDPFSRNFALHYPYELDISKMKLASKRLIGEHDFTSFCSARTERDSKVRTLYSIDFYEEDDETLVIAFQGNGFLYNMVRILTGTLLDAGQGRISPDDISEALLARDRQKLISKTAPPQGLYLWRVDYE
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: MPTA_METBF
Sequence: MEHCTFNLPDVQASKPSIAINLTRVGVTNVKKLVEIKRKDKRPIVLISTFDVFVDLPSDRKGANLSRNFEAVDEVLEKILSMPVYEIEQLCSDIAHNLLGRHEYANQAEVRMTSEYMIRRASPATGIKCQEVVNIFAEASAVRGQGNDDYFDVKKLIGAEVVGMTACPCAQEIMRDKAANELSELGVDKDTIIKFLERVPMATHNQRGRGIISIKVAHDFDVSLESIISIIDHSMSSSVYEVLKRADEKVVVETAHMNPKFVEDCVRTMADNVVKEFPNLPDNAVITIKQTNEESIHRHNAYAERVALMGDLRSEINHC
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: SYE_SINMW
Sequence: MADSAVRVRIAPSPTGEPHVGTAYIALFNYLFAKKHGGEFILRIEDTDATRSTPEFEKKVLDALKWCGLEWSEGPDIGGPCGPYRQSDRKDIYKPYVEQIVANGHGFRCFCTPERLEQMREAQRAAGKPPKYDGLCLSLSAEEVTSRVAAGEPHVVRMKIPTEGSCKFRDGVYGDVEIPWEAVDMQVLLKADGMPTYHMANVVDDHLMKITHVARGEEWLASVPKHILIYQYLGLEPPVFMHLSLMRNADKSKLSKRKNPTSISYYTALGYLPEALMNFLGLFFIQIAEGEELLTMAELAEKFDPENLSKAGAIFDIQKLDWLNARWIREKLSEEQFAAKVLSWAMDNDRLREGLKLSQTRISKLGELPDLAAFLFKSDLGLQPAAFAGVKASPEEMLEILNTVQPDLEKILEWNKESIETELRACAERMGKKLKAVVAPLFVAVSGSQRSLPLFDSMELLGRSVVRQRLKVAAQVVASMAGSGK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIDO1_MOUSE
Sequence: MDDKGHLSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDTEVDPSEQQPQQHNLSLRRSGRQPKRTERVEEFLTTVRRRGKKNVPVSLEDSSEPTSSTVTDVETASEGSVESSSEIRSGPVSDSLGKEHPASSEKAKGGEEEEDTSDSDSDGLTLKELQNRLRRKREQEPVERSLRGSQNRLRKKRREEDSAETGSVQIGSAEQDRPLCKQEPEASQGPVSQSETDDIENQLEGKATQGNTEENPREAGKPKPECEVYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETNGSATDEQDSGCRSVGADGTDCTSIGTVEQKSGEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGAPKCIGPGCSSVAQPDSVYCSNDCILKHAAATMRFLSSGKEQKTKPKEKVKTKPEKFSLPKCSVQVGIKISSVHKRLASEKRENPVKKVMLASRSETSGKEAACESSTPSWASDHNYNAVKPEKPEKPTALSPTLLSKSMKDDRRVEDRTMAAVTIPKKALPSASLVGRQTSPRNLVPKKLPPYSNMAGAKPAIKKLPSGFKGTIPKRPWPSATLSGTSARQAGPTPMTAASKKLPGSAAVVGVTRKPMSANVPAASPAPGRLGPVSPAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPEELVSKELSMWTEKPTKSVIESRTKLLNESKKNTTKPETIPDMEDSPPVSDSEEQQESVRAAPEKSAAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASSKKEDFKPRHDSSPPNAVPNTADEGIADTLPENASEPDPESTSSLNQERKCFPESPGDSHPEPSSLGGLSPSSASGGSGVVTTVTMSGRDPRTALSGSCTVTASMAAHLDNSQASETKLDMIKPALTSAVVPKSILAKPSSSPDPRYLSVPPSPSISESRSPPEGDTTLFLSRLNTIWKGFINMQSVAKFVTKAYPVSGCLDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAKDPVPSKLLPFEGPGLESPRPNIILGLVICQKVKRPSSAGELDKTDEKRTRLQQEELETSVYPKVTAALPSEKKPPKYSVHSIDTAATSTTPPGSPPPPPPLPEPPVLKILSSLKPGSTSTVTAPTTAAITTTASPVTAATSKTASPLEHILQTLFGKKKSFEPSGKESVGSTLSPHQDSKAKGEDTMSAAPLLDPIVQQFGQFSKDKALEEEEEDDRPYDPEEEYNPDRAFHTLLAEPGRPHDVQSVSETAEREEVAYDPEDETILEEAKVTIDDLPNRMCMKVSATERPADFTTDASSASLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQRAAVGVSMAHFSVSDALMSPPPKSSLGKTELFSQEQQAPDPSQGAPNTNHNLDSRQSRDPRQARRLAAENTENESLPRAPTGSTPGPQGTLPARETPAGTAVVQGPGLAAEAKESMAVPWAPGENAVLRPEHDIQKCEHPGNPVSLPLDTSHLPTAGDGAARPAPPRRVLLPTPPSTTFPPSFPLQPKAQNFSSGSREPFSGPTFMSQETSLGSSQYEDPRGAQSAGKNDSPVADMEDSREPQPRPGESTTSFPQPGQRGGGPQPQFPGQREPAPRTFGMSGHHGPSFPGPRGPVPPYSEENLVPNSDGPRGPPPARFGAQKPPIPSLFSGQHGPPPYGDNRGLSPSYLGGPRGGAPAQFEDRKDPHGEKREFQDTPYNEMTGAPAQCEGPDQAQFMGNRAPFQFGGQRRPLLTQMKGPRGGPPPSQFGAQRGPPPGHFVGPRGPHPSQFENSRGTHPGQFEGARGQAPGFMPGPRGIQPQQFEEQRVNSPPRFAGQRASAPLPYGGPRGPAPFPEKNEQPPSRFHFQGPSSQPVKPPPRPLLELPSHPPQHRKDRWDEAGPATALPSSAGPGQGHEADGQWATSEFREGKGHEYRSPAFEGRQRERFEAGSKEKPLDEPEAQGLESRQGRAFEDRRRERERGRNWSRERDWERSRDWDRHREWDKGRDRSSNRDRERDNDRAKEWDRSRERSRNRDRDRERRRDRDRSRSRDRDRDRERARDRDRDRGRDRKDRSKSRESPRDQKPEARTSEGGPAAAQA
What is the function of this protein?
Required for early embryonic stem cell development (By similarity).  Putative transcription factor, weakly pro-apoptotic when overexpressed.
What are the official names of this protein?
Death-inducer obliterator 1, DIO-1, Death-associated transcription factor 1, DATF-1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis (By similarity). Translocates to the nucleus after pro-apoptotic stimuli.
Protein: GCSPB_CHLPD
Sequence: MREKLIFDLSRNGRKGYSLSKNDLPETSVAAVIPSKFLRTTPAELPEVPESEVVRHFIRLSNLNYHVDKNMYPLGSCTMKYNPKVNDYTCDLPGFSTLHPLQPSETTQGALRLMYELSSMLSEIAGMAAVSLQPAAGAHGELTGILLIKKYHEAQGKMRNKLLVVDSAHGTNPASAAIAGYEIISVRSNADGRTDLEDLKARLQSDVAALMLTNPNTIGLFEKDILAIERMVHENGSLLYMDGANMNALLGITRPGDMGFDVVHYNLHKTFSAPHGGGGPGSGPIGVSARLAGYLPVPVIEKEESATGTSYRLNYDRPESIGRMISFYGNFSVLVRAYTYIRMLGPEGLRRVSENAIINANYLLSLLLERYDLPYPKSVMHEFCLSGDRQKKANGVKTLDMAKRLLDYGFHAPTIYFPLIVSEALMIEPTETETKETLERFAEAMIAIADEAENNPALVKSAPETTPVKRLDEAQASRQLNICCSL
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: RS15_ACET2
Sequence: MQKELKQEIINKFKLHETDTGSPEVQIALLTERINHLTEHLKVHKKDYHSRRGLLKMVGHRRGLLNYLMKTDIARYRAIVEKLNLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: CH601_RHOPB
Sequence: MSAKEVKFGVDARDRMLRGVDILANAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKSADLAGDGTTTATVLAAAIVREGAKSVAAGMNPMDLKRGIDLAVEAVVADLVKNSKKVTSNEEIAQVGTISANGDAEIGKFLSDAMKKVGNEGVITVEEAKSLETELDVVEGMQFDRGYISPYFVTNADKMRVEFDDAYILINEKKLSNLNELLPLLEAVVQTGKPLVIVAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQAISEDLGIKMENVTLAMLGKAKKVMIDKENTTIVNGAGKKADIEARVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEIEVKERKDRVDDAMHATRAAVEEGILPGGGVALLRASEQLKRIKTQNDDQKTGVEIVRKALSWPARQIAINAGEDGSVIVGKILEKDQYSYGFDSQSGEYGDMVKKGIIDPTKVVRAAIQNAASVAALLITTEAMIAELPKKGNAGGGMPPGGGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.