Protein: ATR1_STEAL
Sequence: MASNHEELPSMVVFSPQSKAPKEGYLDELRSYLCGKAELRPLLDGIENLPNTWSIFAQRNSDIAALTQGIRYTQALSDWAKHGTSSGISNVMSGILSLPLLTIIQVVQYFQFLEVKKLRHSDFMERLRCRGGVQGYCGGLMPAIAIACSATEAEVVTNAVKAMGIALGVGAYGELGDDENVLGPTTIVVRLKQEGQGGDIIKDFPDAHISAITDPKTVSIVGSAPSLAEIQARVKSNGMQTQAMHLRGKVHNPENANLALELCMLCDEHEELSLPNASHLTAPLRSNKTGKKLLDVSLTHEAIETILASCCQWYDLLKGVCKDLEKTGTQSHLFASFGIGDCIPLTPFHQAGLQITKLDVLSFVKALMPPVLPMSGHNHQYAYPTDAVAVVGMACRLPGANSVEELWDLISSGGSTVTPVPEDRMDIAGSFRAMQDPKWAAKQQWWGNFISDIAGFDHSFFRMSPREAASMDPQQRILLETAYQAMESSGYLGSHRRESGDPVGVFLGASFVEYLDNTSSNPPTAYTSTGTIRAFLSGKISYYFGWTGPSEILDTACSSSLVAINRACKAIQNDECPMALAGGVNLITGIHNYLDLAKAGFLSPSGQCKPFDGAADGYCRSEGAGLVVLKRLSQALTDGNQILGVITGASTNQGGLSPSLTVPHSAAQVKLYQNILHQAGMRPEQVSYCETHGTGTQAGDPLEIESVREVFGGPKRQDSMHIGSIKGNIGHCETAAGVAGLLKALVMVNKAAIPPLASHKSLNPKIAALEPDKLAISSCLEDWRVSPRAALVNSYGAAGSNSAVLLCQAPDIDNAPLHRVATTEHTYPIILSAASKPSLLSNAENIASYLRKATSKCTIADVAFTLVKQRKRHPLQWITMESSIDGLVKSLGSLQDPSNAPQPKKVVMTFSGQSRQSIGLNKEWYDSFPLFRRHVNECDDLLQQSGFPSCKSAMFDKEPARDVVPLQCAMFAVQYASALSWIDCGLQVEAVIGHSFGELTALAVSGTLSLKDALNLVATRATLMQSKWGPHKGTMLLISAATEMVRKIIAGNRDVEIACHNAPTSQIVVGTQAAISEVEKVLENNTEYRGIQSQRLNVTHGFHSQFTEPLLENLSESARSLVFHEPKILLECCTLEELNHVGPDHLARHTREPVYFYHAVRRLEQRLGTCLWLEAGFDSPIIPMTKRAVEFPERHTFLDMKTPSGTNPTKMLTTATINLWQNGATSSFWGFHPIETTNIKQVWLPPYQFDRTSHWMPYTDHALEMSKIQAVISNSEPLVELSTKPPRLVEPRTKPSEKGEFSMNTQARRYTEIVSGHAVLSRPLCPAAMYMECAIMAAQLSIGNIVGQAPWFENLTFEAPLGMDPDNDTTVVLKDDGSKSRWSFVARSTSRSNPKRKPVLHAKGDFGFTTQTQVHRYERLVTDRMRHLQHSKSETLKSKRAYGLFSRIVRYAELLKGISSITLGDSEASAIIDVPLGASTEDSSATGLCDCVALDAFIQVVGLLINSGDDCAEDEVFVATGVENFSMSLACDFDRCRTWLVFAMFTPSGNGKAMGDVFILTRDNVLVMTIMGVQFTKLPITRLEKLLDSANPKAHNTPILKSSQQDSIVSASSSSSTEHSDDDSEDDGSRSPSHSDTSVDSESEAPADNGAAKKLKSLIASYVGIAEDAISDDANIADLGVDSLAATELADEISNDFAKEIDGGELPMMTFGELCRIVAPEMAAKPAKAKKKIPYKGKDEATVVESHPGKSQSEIKDLKAVVEPLPRSTPMLSDTTVVRSDPTQVLRQIDTMFQSSADTFGFTDYWTAVAPKQNKLVLAYIGEEFRKLGLDLWAVQPGATLPHIEYLPKHEKVVQRLWDILADHGIVYNYDAAKVRSSKPLPDAPSTALLNELNALFPNFANENRLMSVTAPHFADGLRGKTDHISLLFGSQRGQECLNDFYNNSPQLAVMTDHLLTFFKQLLKEAPLEGSLRILEVGGGFGGTTKRLAEMLEALGQPVEYTFTDVSSMLVKEARKKFSKHSWMDFQSLNLEKDPPASLQRTYDIVIGTNVVHATSNIVNSTTRMRSLLRKGGFIVLSEVTRIVDWYDLVYGLLDGWWAFKDSRTYPLQPADDWVRDLMKAGFETASYSRGDSEESNTQQLIIGSTRPSKVASTSGLSEARLSKSYRIETMPYKIIDDTEILADVFFPEHEVASEAMPIALMIHGGGFMTLSKTAIRPYQTQFLVENGYLPISIDYRLCPEIDLIAGPMTDVRDALTWVRKQLPAIARTRGINVDPTKVVVIGWSTGGHLALTTAWTCEDIGEEPPVAVLSFYGPTNFESEDIDRRRAEQYPERTMSFDRIRKSLSTKPITSYDCPTGTDSTGLGWVRPGDPRSELVLSLFKESHGLQVMLNGLSAADLAKPPPLAKIQAISPMAQLKAGRYNVPTFVIHSDCDEIAPFRDSEAFVEELARRGVKTGLGRVRGKKHIHDLALKPEKDGWVDGAGVGYEFIFDVVGRGVRG
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of atranorin, a depside of polyketide origin that accumulates in the cortical or medullary layers of lichen thalli (PubMed:34154413).  The first step in the pathway is performed by the non-reducing polyketide synthase atr1 that produces 4-O-demethylbarbatic acid composed of two 3-methylorsellinic acid (3MOA) moieties from S-adenosyl-L-methionine (SAM), acetyl-CoA and malonyl-CoA units (PubMed:34154413).  The pathway continues with the actions of the cytochrome P450 monooygenase atr2 that catalizes the oxidation of c-9 and the O-methyltransferase atr3 that performs the methylation of the carboxyl group to yield atranorin, via the proatranorin II and III intermediates if atr2 acts first, or the proatranorin I intermediate if atr3 acts first (PubMed:34154413).
What are the official names of this protein?
Non-reducing polyketide synthase atr1, Atranorin biosynthesis cluster protein 1.