PharMolix/UniProtQA huggingface dataset:
Protein: ADM1B_MOUSE
Sequence: MERLKLGKIPEHWCIRLVAMLLLAIIFLPSTFCDIGSVYNSSYETVIPERLPGKGGKDPGGKVSYMLLMQGQKQLLHLEVKGHYPENNFPVYSYHNGILRQEMPLLSQDCHYEGYMEGVPGSFVSVNICSGLRGVLIKEETSYGIEPMLSSKNFEHVLYTMEHQPVVSCSVTPKDSPGDTSHPPRSRKPDDLLVLTDWWSHTKYVEMFVVVNHQRFQMWGSNINETVQAVMDIIALANSFTRGINTEVVLVGLEIWTEGDPIEVPVDLQTTLRNFNFWRQEKLVGRVRHDVAHLIVGHRPGENEGQAFLRGACSGEFAAAVEAFHHEDVLLFAALMAHELGHNLGIQHDHPTCTCGPKHFCLMGEKIGKDSGFSNCSSDHFLRFLHDHRGVCLLDEPGRQSRMRRAANCGNGVVEDLEQCDCGSDCDKSQCCDENCKLKGNSVCSTELCCFKCNFKKEGDVCRPADGPCDLEEYCNGTSAACPSDRKAQDGSKCHESFLCFNGQCMDPTFQCSRIFGHGSRSASDYCYTSLNSRGDQFGNCGSSSQFPKKYTKCSDKNVMCGKLICTEVAFLPQIQPNNLLLQVPETEDWCWSVAVFDMRDSLHEEYVKDNTYCGKDKVCKNSICEDFTPFSFPCSPSKQCNKHGVCNDLGNCHCSFGFAPPDCKEEGTGGSVDSGPAVNLSNDSSPGPNSTQSSTEELILNLKLIVLAVILVLMILLIIICIISAYTKSETASEAGPSELEELPEGEKEEQEEVLPEEAKGEEEELEYGKEEAEEQGAVEEEGAEEANEEAAAEKKDEDEEEGEE
What is the function of this protein?
May play a role in spermatogenesis and sperm maturation.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 1b, ADAM 1b, Fertilin subunit alpha-b.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HEM1_XANCB
Sequence: MTLWVLGLNHQTAPVDLRERAAFAGDALPRALDSLRTLPQVREAALLSTCNRTELYAMADDPQTLVAWLDMHAPGLSGYLYQHRDAEAVRHLFRVATGLDSMVLGEPQILGQVKDAWAVARAHGALGSGLDRLFQQTFSVAKRARTDTRVGANPVSVASTAVRLAQESFARLNESTVLLVGAGETIELAAKHLSEGRVRRLLIANRTLAHAQTLATQHGGVALPLTELDRHLAEADVVFSATAAREPVVTRVQVEQALRTRKRKPMLLFDLAVPRDIEASVAELSDAYLYTVDDLERAVEDNRRSRREAADQAEAIIDLQVARYVETLQANERQAPLKRLRAFGDSTRDELLAKARQQLSNGKPADEVLEQLAHALTNRLLHPPTAALRDAALNNDLDLTSAADRLFPEKPGYRHPPVATPIVRTDDANPAP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: IF3_STRZT
Sequence: MFFSNKTKEVKTIAKQDLFINDEIRVREVRLIGLEGEQLGIKPLSEAQALADNANVDLVLIQPQAKPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPTIDKGDFDTKLRNARKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKMDGRQMFMQLAPATDKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_XENLA
Sequence: MKPLVVFVLGGPGAGKGTQCERIVQKYGYTHLSAGDLLRDERKKPDSQYGELIESYIRDGKIVPVEITISLLQRAMERTMAFDANKHKFLIDGFPRNEDNLQGWERTMNGKADVSFVLFFDCDNETCIERCLERGKSSGRSDDNRESLEKRIQTYLQSTRPIIDLYEKRGKVRKVDASKSVDEVFTKVQNIFD
What is the function of this protein?
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP.  Plays an important role in de novo pyrimidine nucleotide biosynthesis.  Has preference for UMP and CMP as phosphate acceptors.  Also displays broad nucleoside diphosphate kinase activity.
What are the official names of this protein?
UMP-CMP kinase, Deoxycytidylate kinase, CK, dCMP kinase, Nucleoside-diphosphate kinase, Uridine monophosphate/cytidine monophosphate kinase, UMP/CMP kinase, UMP/CMPK.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly nuclear.
Protein: RS6_BOVIN
Sequence: MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKDGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK
What is the function of this protein?
Component of the 40S small ribosomal subunit.  Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: MES4_ARATH
Sequence: MEKNNKKRFVLVHGLCHGAWCWYKVKTHLEAVGHCVTAVDLAASGINMTRLEEIQTLKDYCKPLLELLNSLGSDDDKVILVAHSMGGIPAALASDIFPSKIATIVFLTAFMPDTRNLPAYVYQKLIRSVPQEGWLDTVFGTYGKHECPLEFALFGPKFMAKNLYQLSPVQDLELAKMLVRVNPIITNNLAGTRSFSEEGYGTVTRIYIVCGEDMAVPEDYQWWMIKNFPPKEVMEIKCADHMAMFSKPHKLCALLVEIACKYA
What is the function of this protein?
Methylesterase shown to have carboxylesterase activity and methyl salicylate (MeSA) esterase activity in vitro.
What are the official names of this protein?
Methylesterase 4, AtMES4, Alpha/beta fold hydrolase/esterase 4.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Methylesterase family.
Protein: BDGED_DROME
Sequence: MSSKEQQAAGRDFKRNSNAYSSLPPTGTGAGCSGAALGSGTGTGKRARSKQHQLEHEQFGLSNSLSSESIRQACAYYDDELSDEDLIEIQQTPQAFHQQTKQPLQLQPISFRLGDELGDERSAFCGSQEMQQVPLSTPIKQAAETDEALCVLSELDAILDVHDVSQLNGTCSSGSVNSGSDDDKVEDYLMDLDNYLEEMDNALNREDSLIIIDGHTSLKREPRTRTLPLSRKKKSSKKKSEDQEAAQGDFQREHQLRKTFSCSLRPTSQIASSSGSLETSTEPVMDVWRRQSMRRALEQEDTKATVAMEREEDDIPTLLVELPPRRDAEMRRCFSQGDCQASVAPTVGSQMLTEAHIFDNLLQTNARASSEEPRPRQYGRRLEGPPTPVRPLILAQSRPQSAPTRVQMREPQLQDTPTHPIMSTCSELSSARSSRMPSPVSLPSDSSSSGSSSAEHDQEPDPVQTTTMCSASSTTPLEPLHQLQLLLREKCGFNSQWPHAGSRTLALIGCTLGVFNMCRFAVLTINFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMWKISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFPTAARSGYRWQEMAFPYRYDASNATGNLTQTVAEYFNVVVLQRLHLANHPDASGIRFHVNDRQLAFYLALIWAAVFLILCKGLKSLGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDFLVNSNSWTAATQETFLTWGLLGASVIAITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYVYVPGSFENPDCYTSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVESGFQALRFISEIFPAVLSLASDSISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSVLLSCVTGLLLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFGVFLIRGRPYNGDDLVNDLRLCGSMSAFLALSWNVLLPIGLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPEEGEEPRRPSARQTASQSRRNALGQTTEGGQHDAQNDAPPKYTPPPSYTTATGARLAKLLRQSIRRSVRRVLGDSSRTRPVLSLDAESASPAAPPDYLTILTNPAGSSFNADPSPASSSSPESIEIDQRPVGYSQRSQSLGRKLHRSGASTLERRPYTAEDVVTILRSSVRHRQSQGGGNLVTASTLPRPPTAAMSTHLEDASFRSIENLVLNAEPPDRTPGVELELELEAGQAEECARNNTSVI
What is the function of this protein?
Putative sodium-dependent transporter which is required for viability, early imaginal disk development and adult motor coordination (PubMed:17890365).  Also has a role in the fate commitment of the R3/R4 photoreceptor cells (PubMed:17890365).  May function in ommatidial polarity by regulating the activity of the core polarity genes, acting upstream of (or in parallel to) Vang, dsh, pk, stan, and dgo, but downstream or independently of fz (PubMed:17890365).
What are the official names of this protein?
Sodium-dependent transporter bedraggled.
What is the protein family that this protein belongs to?
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TOMT_RAT
Sequence: MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRSFRDCLSGLRIEERAFSYVITHALPGDPGHILTTLDHWSSCCEYLSHMGPIKGQILMRLVEEKAPACVLELGTHCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG
What is the function of this protein?
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity).  Required for auditory function (By similarity).  Component of the cochlear hair cell's mechanotransduction (MET) machinery.  Involved in the assembly of the asymmetric tip-link MET complex.  Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells.  The function in MET is independent of the enzymatic activity (By similarity).
What are the official names of this protein?
Transmembrane O-methyltransferase homolog, Catechol O-methyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Note=Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia. Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern.
Protein: ISPE_ALCBS
Sequence: MTLTLPAPAKLNLFLHITGRRDDGYHQLQTVFALLDHGDTLRFSPADTLSLQCHQEGGASDLPTDDSNLILQAARALQAHTGSSKGAAITLTKRLPMGGGVGGGSSDAATALLGLNAFWALGLTLQELAHIGLTLGADVPVFVFGKSAWAEGVGEKINPIILPNDAFLVVHPGIHVSTARIFGDQQLTRDTPISKLPASLETVLTREFHNDCEAVATQHFPEIGKTLDWLKQHTGNARMTGTGACCFSRLTGLQQGQQLLQQLPQHWTGFVARSCNTSPLHQILGEALAKFRETKNSGKPA
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RSLBA_HUMAN
Sequence: MRPLSMSGHFLLAPIPESSSDYLLPKDIKLAVLGAGRVGKSAMIVRFLTKRFIGDYEPNTGKLYSRLVYVEGDQLSLQIQDTPGGVQIQDSLPQVVDSLSKCVQWAEGFLLVYSITDYDSYLSIRPLYQHIRKVHPDSKAPVIIVGNKGDLLHARQVQTQDGIQLANELGSLFLEISTSENYEDVCDVFQHLCKEVSKMHGLSGERRRASIIPRPRSPNMQDLKRRFKQALSPKVKAPSALG
What is the function of this protein?
Regulator of rDNA transcription.  Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).
What are the official names of this protein?
Ras-like protein family member 11A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Associates with rDNA transcription unit throughout the cell cycle.
Protein: AC4CH_ECOHS
Sequence: MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELIKVIADIYPGQTQFYVIEFKCL
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: DHYS_SCHPO
Sequence: MDESLAKDAVFVASSKPSDLTTEVVGPDFNKYDERKKAGGPGITVEELVESYGKIGFQATNLHDAVTIINEMRNWRDPNPPEEKSDRATIFLGYTSNLISSGVREVLRYLVQHKCVDVIVTTAGGVEEDIIKCLGPTYVGDFHLDGKNLRAKGLNRIGNLIVPNDNYCRFEEWIFPILNKMVEEQETLGTHWTPSSFIRRLGKEINDESSVLYWAYKNNIPIYSPALTDGSIGDMLYFHTYKATPRPLVLDIVADIRNMNTHAVRANKSGIIILGGGVVKHHICNANLMRNGAEWSVYINSANEFDGSDAGARPDEAVSWGKIRGDAKKVKVYGEVSLLFPLIVAATFAK
What is the function of this protein?
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
What are the official names of this protein?
Probable deoxyhypusine synthase, DHS.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: NLTPE_ARATH
Sequence: MTRSFSPVVSLFLLLLQTICSATVENAADCAAVGTLISSCTEFVNYGYPDPIPGSSCCDAMTVIGTYSDSSEKRKWLCNCFMDLINVYNSNATAISTLSGFCGVVLGFTIDPNTDCNFIQ
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
What are the official names of this protein?
Putative non-specific lipid-transfer protein 14, LTP 14.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: 3MGH_NITMU
Sequence: MSMSQPSIDFSASSVDVARSLIGATLLVNGVGGRIVETEAYDHDDPASHSFSGPTRRNQVMFGPPCHAYIYRSYGIHWCLNFVCRPAGHGAGVLIRAIEPLVGLDIMRKRRGLSDERLLCSGPGRVCEALGITQEYSGMSIDTPPFQLTPPLDPVPVVTGPRIGISKAKDVPWRFGLAGSPFLSRPFRQPDIV
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: RL17_BRUO2
Sequence: MRHGNGYRKLNRTASHRKAMFANMAASLIEHEQIVTTLPKAKEIRPIVEKLVTLGKRGDLHARRQAISAIRDVKLVAKLFDTLAARYATRNGGYIRIMKAGFRAGDNAPLAVVEFVERDVDAKGKADRARVEAEAAAEADAA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: TRI3_TRIAR
Sequence: MGSKLPELPKLSPEKHRWEKSNVDPRVLQRRGIGSEAIVGMERSNRRGQYDLYLLATLRTAHVSTSTPLSLLYLKEKLELALLVMRFEHPECACTVTWDDQVPPIIQYASPQNDEEALMWAKSSVHIRTTSQTGFDVRYEIEGKRQDLDQDNMEPSRPIVIYLISNVTNGDAQLTSGATVDVLLHMNHLFWDGISARMFTGDLFRELNKLINSNEQELPKLQWGTEASNLSAPVLDALKINIEELREEFEAASNQFVKALYENYGGWGLEFKSGLGLPRTDIHTSTATESKAIINGVKTRLGPQYTISHLAQAAVVIAMLEIIQPPNLTDKDIFVSPMPVNGRRWLKDGLADHHYSICETGAVIRIENIKSLVLNNNNDKGYRPRCDEKKPGEDVKKSFDQWLGNPYQLALGLAVHTLEASFLTANPMPFDKVAAPFFISDGRNEQFIPASITTTTGEILMTIDNFVFFLNQCLPYLAIRLESWKDASTLSVCYNKANYSQEEATKFLKCVAKYMLIFSQ
What is the function of this protein?
Trichothecene O-acetyltransferase; part of the gene cluster that mediates the production of the antimicrobial trichothecene harzianum A (HA) that plays a role in Botrytis cinerea antagonistic activity and plant defense priming (PubMed:21642405).  The biosynthesis of harzianum A begins with the cyclization of farnesyl diphosphate to trichodiene and is catalyzed by the trichodiene synthase TRI5 (PubMed:21642405).  Trichodiene undergoes a series of oxygenations catalyzed by the cytochrome P450 monooxygenase TRI4.  TRI4 controls the addition of 3 oxygens at C-2, C-11, and the C-12, C-13-epoxide to form the intermediate isotrichodiol (PubMed:21642405).  Isotrichodiol then undergoes a non-enzymatic isomerization and cyclization to form 12,13-epoxytrichothec-9-ene (EPT) which is further converted to trichodermol by the cytochrome P450 monooxygenase TRI11 via C-4 hydroxylation (PubMed:21642405).  The last step of HA synthesis is esterification of an octatriendioyl moiety to the C-4 oxygen of trichodermol.  The octatriendioyl moiety is probably produced by the polyketide synthase TRI17 and the esterification performed by the trichothecene O-acetyltransferase TRI3 (Probable).
What are the official names of this protein?
Trichothecene O-acetyltransferase TRI3, Trichothecene biosynthesis cluster protein 3.
What is the protein family that this protein belongs to?
Belongs to the trichothecene O-acetyltransferase family.
Protein: RL17_XANOR
Sequence: MRHQKSGRKFNRTSAHREAMFRNMAASLFKHELIKTTLPKAKELRRVAEPLITIGKVDGVANRRLAFARLRDKEAVGKLFVELGSRYATRPGGYLRILKAGFRAGDNAPMAYVELVDRPVVAEEVAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RL7_LISMO
Sequence: MALNIEEIIASVKEASVLELNDLVKAIEEEFGVTAAAPVAVAAAGGAAAEQTEFTVELASAGDSKIKVIKVVREITGLGLKEAKELVDNAPKALKEGIAKDEAEEIKAKLEEVGANVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: CENPX_BOVIN
Sequence: MEETGAVFRKELVSKLLHLHFKDKKTKVSGDALQLVAELLKIFVVEAAIRSVRQAQAEGLAHVDVEQLEKVLPQLLLDF
What is the function of this protein?
DNA-binding component of the Fanconi anemia (FA) core complex.  Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage.  In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA.  Stabilizes FANCM.  In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks.  In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression.  As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.  DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded.  Does not bind DNA on its own.
What are the official names of this protein?
Centromere protein X, CENP-X, FANCM-interacting histone fold protein 2, Fanconi anemia-associated polypeptide of 10 kDa, Stimulated by retinoic acid gene 13 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CENP-X/MHF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS.
Protein: CAN5_MOUSE
Sequence: MFSCAKAYEDQNYSALKRACLRKKVLFEDPLFPATDDSLYYKGTPGPTVRWKRPKDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVIVDDRLPTVNNQLIYCHSNSKNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDLATDEAKRNQLFERVLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDMCRYFTDIIKCRLINTSYLSIHKTWEEARLHGAWTRHEDPQQNRSGGCINHKDTFFQNPQYVFEVKKPEDEVLISIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTELPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVAQVHVLGAAGLKDSPTGANSYVIIKCEGEKVRSAVQRGTSTPEYNVKGIFYRKKLAQPITVQVWNHRVLKDEFLGQVHLKTAPDDLQDLHTLHLQDRSSRQPSDLPGIVAVRVLCSASLTAV
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease.
What are the official names of this protein?
Calpain-5, New calpain 3, nCL-3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
Protein: CCL11_HUMAN
Sequence: MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP
What is the function of this protein?
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956).  Binds to CCR3 (PubMed:8631813).
What are the official names of this protein?
Eotaxin, C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: METK2_TOBAC
Sequence: METFLFTSESVNEGHPDKLCDQVSDAILDACLEQDPESKVACETCTKTNMVMVFGEITTKAKVDYEKIVRDTCRGIGFTSADVGLDADHCKVLVNIEQQSPDIAQGVHGHLTKKPEEIGAGDQGHMFGYATDETPELMPLTHVLATQLGAKLTEVRKNKTCPWLRPDGKTQVTVEYKNDNGAMVPIRVHTVLISTQHDEGVTNEQIAQDLKEHVIKPVIPAKYLDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGEGAFSGKDPTKVDRSGAYIVRQAAKSVVAAGLARRCIVQVSYAIGVAEPLSVFVDTYKTGTIPDKDILALIKENFDFRPGMIAINLDLLRGGNFRYQKTAAYGHFGRDEADFTWETVKALKPKA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGC_SALA4
Sequence: MSSVPAPREYFLDSIRAWLMLLGIPFHISLIYSTHSWHVNSATPSWWLTLFNDFIHAFRMQVFFVISGYFSYMLFLRYPLKRWWKVRVERVGIPMLTAIPLLTLPQFILLQYVKEKTENWPTLSAYEKYNTLAWELISHLWFLLVLVILTTVSIGIFTWFQKRQETSKPRPAAISLARLSLIFFLLGMAYAAIRRIIFIVYPAILSDGMFNFIVMQTLFYVPFFILGALAFIHPDLKARFTTPSRGCTLGAAVAFIAYLLNQRYGSGDAWMYETESVITMVMGLWMVNVVFSLGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHISSNLIGFLCGLIFVMGIALILYEIHLRIPLLKFLFSGKPPVKQESRAAIG
What is the function of this protein?
Necessary for the succinyl substitution of periplasmic glucans.  Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.
What are the official names of this protein?
Glucans biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family. OpgC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LIPA_STAA2
Sequence: MATKNEEILRKPDWLKIKLNTNENYTGLKKMMREKNLNTVCEEAKCPNIHECWGARRTATFMILGAVCTRACRFCAVKTGLPNELDLNEPERVAESVELMNLKHVVITAVARDDLRDAGSNVYAETVRKVRERNPFTTIEILPSDMGGDYDALETLMASRPDILNHNIETVRRLTPRVRARATYDRTLEFLRRSKELQPDIPTKSSIMVGLGETIEEIYETMDDLRANDVDILTIGQYLQPSRKHLKVQKYYTPLEFGKLRKVAMDKGFKHCQAGPLVRSSYHADEQVNEAAKEKQRQGEAQLNS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS2_MYCTO
Sequence: MPARRSAARIDFAGSPRPTLGVEWEFALVDSQTRDLSNEATAVIAEIGENPRVHKELLRNTVEIVSGICECTAEAMQDLRDTLGPARQIVRDRGMELFCAGTHPFARWSAQKLTDAPRYAELIKRTQWWGRQMLIWGVHVHVGIRSAHKVMPIMTSLLNYYPHLLALSASSPWWGGEDTGYASNRAMMFQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDHMDEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGETLPTMPPWHVQENKWRAARYGLDAVIILDADSNERLVTDDLADVLTRLEPVAKSLNCADELAAVSDIYRDGASYQRQLRVAQQHDGDLRAVVDALVAELVI
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: YFHG_SHIFL
Sequence: MRHIFQRLLPRRLWLAGLPCLALLGCVQNHNKPAIDTPAEEKIPVYQLADYLSTECSDIWALQGKSTETNPLYWLRAMDCADRLMPAQSRQQARQYDDGSWQNTFKQGILLADAKITPYERRQLVARIEALSTEIPAQVRPLYQLWRDGQALQLQLAEERQRYSKLQQSSDSELDTLRQQHHVLQQQLELTTRKLENLTDIERQLSTRKPAGNFSPDTPHESEKPAPSTHEVTPDEP
What are the official names of this protein?
Uncharacterized protein YfhG.
Protein: RL32_MYCBT
Sequence: MAVPKRRKSRSNTRSRRSQWKAAKTELVGVTVAGHAHKVPRRLLKAARLGLIDFDKR
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.