PharMolix/UniProtQA huggingface dataset:
Protein: TCS1_CAMSI
Sequence: MELATAGKVNEVLFMNRGEGESSYAQNSSFTQQVASMAQPALENAVETLFSRDFHLQALNAADLGCAAGPNTFAVISTIKRMMEKKCRELNCQTLELQVYLNDLFGNDFNTLFKGLSSEVIGNKCEEVPCYVMGVPGSFHGRLFPRNSLHLVHSSYSVHWLTQAPKGLTSREGLALNKGKIYISKTSPPVVREAYLSQFHEDFTMFLNARSQEVVPNGCMVLILRGRQCSDPSDMQSCFTWELLAMAIAELVSQGLIDEDKLDTFNIPSYFASLEEVKDIVERDGSFTIDHIEGFDLDSVEMQENDKWVRGEKFTKVVRAFTEPIISNQFGPEIMDKLYDKFTHIVVSDLEAKLPKTTSIILVLSKIDG
What is the function of this protein?
Involved in the biosynthesis of caffeine (PubMed:10984041, PubMed:16333668, PubMed:26773541, PubMed:30303011, PubMed:25133732).  Catalyzes the conversion of 7-methylxanthine (7mX) to theobromine and of theobromine to caffeine (PubMed:10984041, PubMed:16333668, PubMed:26773541, PubMed:30303011, PubMed:25133732).  Has 3-N- and 1-N-methylation activity (PubMed:10984041, PubMed:16333668).
What are the official names of this protein?
3,7-dimethylxanthine N-methyltransferase TCS1, TCS1a, Caffeine synthase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Protein: HISZ_AROAE
Sequence: MRWVLPDHIQDALPAEADKIERLRRRLLDAFRSHGYQLVVPPLLEYLDSLTTGAGQDLKLRTFKLVDQLSGRTMGVRADMTPQVARIDAHLLNRRGVSRLCYCGSVLHTLPSTLTATREPLQLGAELYGHAGLDADIEIIRLLAEVMRLAEVPASRIDLGHVGLFRVLAARAGMVPGREEELFDLLQAKDLPDLHALVAGVAEPVRSALLALPGLYGGAEVLDKARVCLPDDAEIREALDDLSRLAAALGDLPVSFDLADLRGYHYHSGVVFAAYGGGSPAALALGGRYDRVGEAFGRGRPATGFSLDLRELAVRLADVGQPGAILAPAGGDAALEALVAQLRSRGEVVMTELPGHDGSWNEAGCDRQLIRREGRWTVESLQGE
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP6_ROTH6
Sequence: MNRLQQRQLFLENLLVGVNSTFHQMQKLSINTCCRSLQRILDHLILHQTIHSPAFRLDRMQLRQMQMLACLWIHQHNHDHQVILDAIKWISP
What are the official names of this protein?
Non-structural protein 6, NSP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus A NSP6 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host mitochondrion. Note=Found in spherical cytoplasmic structures, called viral factories, that appear early after infection and are the site of viral replication and packaging.
Protein: FRUK_BIFLO
Sequence: MTDKNPIVVMKGITIEFPGVKALDGVDLTLYPGEVHALMGENGAGKSTMIKALTGVYKINAGSIMVDGKPQQFNGTLDAQNAGIATVYQEVNLCTNLSVGENVMLGHEKRGPFGIDWKKTHEAAKKYLAQMGLESIDPHTPLSSISIAMQQLVAIARAMVINAKVLILDEPTSSLDANEVRDLFAIMRKVRDSGVAILFVSHFLDQIYEITDRLTILRNGQFIKEVMTKDTPRDELIGMMIGKSAAELSQIGAKKARREITPGEKPIVDVKGLGKKGTINPVDVDIYKGEVVGFAGLLGSGRTELGRLLYGADKPDSGTYTLNGKKVNISDPYTALKNKIAYSTENRRDEGIIGDLTVRQNILIALQATRGMFKPIPKKEADAIVDKYMKELNVRPADPDRPVKNLSGGNQQKVLIGRWLATHPELLILDEPTRGIDIGAKAEIQQVVLDLASQGMGVVFISSELEEVVRLSDDIEVLKDRHKIAEIENDDTVSQATIVETIANTNVNTGKEA
What is the function of this protein?
Part of the high-affinity ABC transporter complex FruEKFG involved in fructose uptake.  Can also transport ribose and xylose, with lower affinity.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Fructose import ATP-binding protein FruK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: QUEC_HELPS
Sequence: MEQEICAISFSGGQDSTTLAVWAKKRFKKVYLVGFDYAQKHSVELECAQKIASLLQLPYEIIPLDFLENITHSALFKNSNDLMGHSHAQNKDLPNSFVPNRNAIFITLLHSYAQKIGASNIALGVSQADFSGYPDCKEDFIKSIEHALNLGSNTAIKILTPLMFLNKAQEFQMAKDLGVLDLVIKETHTCYQGERKILHAYGYGCGECPACQLRKKGYEEFESNKK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: G3P_XENLA
Sequence: MVKVGINGFGCIGRLVTRAAFDSGKVQVVAINDPFIDLDYMVYMFKYDSTHGRFKGTVKAENGKLIINDQVITVFQERDPSSIKWGDAGAVYVVESTGVFTTTEKASLHLKGGAKRVVISAPSADAPMFVVGVNHEKYENSLKVVSNASCTTNCLAPLAKVINDNFGIVEGLMTTVHAFTATQKTVDGPSGKLWRDGRGAGQNIIPASTGAAKAVGKVIPELNGKITGMAFRVPTPNVSVVDLTCRLQKPAKYDDIKAAIKTASEGPMKGILGYTQDQVVSTDFNGDTHSSIFDADAGIALNENFVKLVSWYDNECGYSNRVVDLVCHMASKE
What is the function of this protein?
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively.  Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity).  Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis.  Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, Peptidyl-cysteine S-nitrosylase GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Nucleus.
Protein: PA2A1_PSETE
Sequence: MHPAHLLVLLGVCVSLLGAARIPPLPLSLDDFSNLITCANRGSRSWLDYAHYGCFCGSGGSGTPVDDLDRCCQVHDNCFGDAEKLPACNYLFSGPYWNPYSYKCNEGEITCTDDNDECAAFICNCDRTAAICFAGATYNDENFMVTIKKKNICQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows moderate enzymatic activity and exhibits procoagulant activity.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 1, svPLA2, Phosphatidylcholine 2-acylhydrolase, Pt-PLA1.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SUSD3_HUMAN
Sequence: MRWAAATLRGKARPRGRAGVTTPAPGNRTGTCAKLRLPPQATFQVLRGNGASVGTVLMFRCPSNHQMVGSGLLTCTWKGSIAEWSSGSPVCKLVPPHETFGFKVAVIASIVSCAIILLMSMAFLTCCLLKCVKKSKRRRSNRSAQLWSQLKDEDLETVQAAYLGLKHFNKPVSGPSQAHDNHSFTTDHGESTSKLASVTRSVDKDPGIPRALSLSGSSSSPQAQVMVHMANPRQPLPASGLATGMPQQPAAYALG
What is the function of this protein?
May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.
What are the official names of this protein?
Sushi domain-containing protein 3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Prominently localized to cell-cell borders.
Protein: LEXA_ACISJ
Sequence: MLDSPKLTARQQQILDLIQTAIARTGAPPTRAEIAAELGFKSANAAEEHLQALARKGVIELVSGTSRGIRLRGETVRNINAARGAQFNLPIPGLSQLTLPLVGRVAAGSPILAQEHVDQTYTVEGSLFAHKPDYLLKVRGMSMRDAGIMDGDLLAVQATREARNGQIIVARLGDDVTVKRLRRTGSAIELLPENPDYPVIRVEPGEPFEIEGLAVGLIRNTMLM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: AMY2_ECOLI
Sequence: MRNPTLLQCFHWYYPEGGKLWPELAERADGFNDIGINMVWLPPAYKGASGGYSVGYDSYDLFDLGEFDQKGSIPTKYGDKAQLLAAIDALKRNDIAVLLDVVVNHKMGADEKEAIRVQRVNADDRTQIDEEIIECEGWTRYTFPARAGQYSQFIWDFKCFSGIDHIENPDEDGIFKIVNDYTGEGWNDQVDDELGNFDYLMGENIDFRNHAVTEEIKYWARWVMEQTQCDGFRLDAVKHIPAWFYKEWIEHVQEVAPKPLFIVAEYWSHEVDKLQTYIDQVEGKTMLFDAPLQMKFHEASRMGRDYDMTQIFTGTLVEADPFHAVTLVANHDTQPLQALEAPVEPWFKPLAYALILLRENGVPSVFYPDLYGAHYEDVGGDGQTYPIDMPIIEQLDELILARQRFAHGVQTLFFDHPNCIAFSRSGTDEFPGCVVVMSNGDDGEKTIHLGENYGNKTWRDFLGNRQERVVTDENGEATFFCNGGSVSVWVIEEVI
What are the official names of this protein?
Cytoplasmic alpha-amylase, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQEI_ECOLI
Sequence: MYWIINDNIEFWPEHRKLISVHNADLNVVLTTPASRCLSLLLEAFPDVVAQQDFFTRVWEEEGMRVPTNTLYQNISIIRRGFRAVGDTTHSLIATVPRRGFKIHNDINIQNHVINSSTDAHTHNAPPAIKVNAGYKESIGGAKNFNNKILKHIKSHLIMLSAFVIGAYSAYWLWNNNQPKPFFKDYKTVAEINGCHFNVTEDTIDGLKEFDKYKTRILDSGINCKKHPWLYFPLAKSSPGMIVMACNKNYNQHEVANCLTLSYREVNRD
What are the official names of this protein?
Uncharacterized protein YqeI.
What is the protein family that this protein belongs to?
To V.cholerae cholera toxin transcriptional activator (ToxR).
Protein: DNAB_RICCN
Sequence: MARNKINNETNILADNEDNLPIPRVLPSNVQAEQMLLGAILTNNELLNYVSEFLRDEHFFEPIHQKIYKAIEKITEKGLTATPITLRSMLTQDELFQEVEGAEYLAKLITMSMMVINPLDYGKIIYDLAIKRNLINIGEEVVNNAYNSSLEVEAKEQIEHAEAKLYDLASEGLNEKSFTKIGISISESLASINRAMKNNDHIIGISTGLIDLDNKLCGFHNSDLIILAGRPSMGKTAFAINLALNACNNMRLKNIRDNQEIQSVGFFSLEMSSEQLTTRLLSMCAEIDSTSLRTGILGEEKYNRLRKEANTLSELQFFIDDTPALSISAIRTRARRMKRKHNLGILFIDYLQLIRGVSKSENRVSEISEITQGLKAIAKELNIPVIALSQLSRAVELREDKKPMLSDLRESGTIEQDADIVMFIYREEYYLTRKEPAAGDAKHAAWLDKLNKVYNIADIIVAKHRNGPVGNVPLYYDSQFSKFGNLETRTFNSN
What is the function of this protein?
Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
What are the official names of this protein?
Replicative DNA helicase.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DnaB subfamily.
Protein: CRG3_XENLA
Sequence: MGKIFFYEDKNFQGRSYECNSDCSDLSSYFNRCNSIRVESGNWILYEQPSYRGHQYYLWKGEYPDFQRWMGFNDSIRSCRMSPYHQGQYKMRISERGDFQGQNMEFFEDCPNTYDRFRFRDIHSCNVFDGNWMFYEEPNYRGRQYYLRPGEYRRYSDWGASSARIGSFRRVHHIF
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin-3, Gamma-3-CRY, Gamma-crystallin III.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: GLCM1_CAMDR
Sequence: MKFFAVLLLASLAATSLASLNEPKDEIYMESQPTDTSAQVIMSNHQVSSEDLSMEPSISREDLVSKDDVVIKSARRHQNQNPKLLHPVPQESSFRNTATQSEETKELTPGAATTLEGKLVELTHKIIKNLENTMRETMDFLKSLFPHASEVVKPQ
What are the official names of this protein?
Glycosylation-dependent cell adhesion molecule 1, GlyCAM-1, Lactophorin, Proteose-peptone component 3, PP3, Whey protein.
What is the protein family that this protein belongs to?
Belongs to the PP3/GlyCAM-1 family.
Protein: SSB_CAMJE
Sequence: MFNKVVLVGNLTRDIEMRYAQSGSAIGASAIAVTRRFTANGEKREETCFIDISFYGRTAEVANQYLTKGSKVLIEGRLRFEQWSDQNGQNRSKHSIQVENMEMLGNSNAPQQGGNFGNNSFSNNNYSGNYENQSYDPYMSENQNFNKAKANPAPQRNQSPQHEEKLKEIDIDAYDSDDTNLPF
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: ASD1_NEUCR
Sequence: MGFLTLFHMAFLAVSLFVSGALAAFGYTTSGNNFVIDAGSANPLIFSVSKSSCDINSIRYRGTELQYSKQGSHIGSGLGKATVSVSQINGSKSKFIKVTCVTSTLTQYMIVKEADSTIYMATYITAEPAIGELRFIARLLSDKLPYEYPYGEVSTTKGSSSTVEGSDVFVVNGQTRSKFYSSTRFIDEDSHCVYGGSDLTHVCIITPQQESSSGGPFFRDIDSNNAGESTNLYNYMNSGHVQTEDRRMGLHGPYLMTFSRSGIPKLKTVDISWFGELGVTGYVPDSQRGTVIGRATGIPSGFEGVVHWYNAAAQYWVRTAPNGDFTSPKMKPGTYTMVLYQTEFKVATSTVTVSAGKTTTASIASTFNTSHTTLFKIGEYDGQPTGFRNADKFLRMHPSDSRMSSWGPLTYTVGSSSLNDFPMAVFKSVNNPVTIKFNLGSAPSQATTLRIATTLSFAGARPQVVVNGWSAPAPAAPAKIDSRGVTRGAYRGYGEVYDVAVPAGKLISGTNTITISALSGSSGATFLSPNFIFDAVELFY
What is the function of this protein?
Could be a pectinolytic enzyme that hydrolyzes the alpha-L-rhamnopyranosyl-(1,4)-alpha-D-galacturonopyranosyl glycosidic linkage by beta-elimination, thereby generating oligosaccharides terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue.
What are the official names of this protein?
Putative rhamnogalacturonase, Ascus development protein 1, Asd-I, Rhamnogalacturonan lyase, RGase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 4 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMG_BACCQ
Sequence: MNIEQFQSMLEEKGITLSSRQLEQFEIYFETLVEWNEKMNLTAITEKEEVYLKHFFDSITAAFYYDFSKPFSICDVGAGAGFPSIPLKICFPHLKVTIVDSLQKRINFLNHLAQKLELSDVAFCHDRAETFGKKEGVREAYDIVMARAVARLSVLSELCLPLVKVGGTFIAMKGAAANEEIENGKYALEVLGGDLKEMSTFQLPFEESERNILLIEKKRKTPKKYPRKPGTPNKLPIEK
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXT_ALKCK
Sequence: MKIGVLALQGAVSEHIRLLTNSGAEAIEIKRADQLAEVDGLILPGGESTAMRRLIDKYQLFKPLREFGESGKPILGTCAGLILMAKTLSGEQDGHLGFIDMVVERNAFGRQRDSFEATLDVKGVAEKLTAVFIRAPLVKEVGPDVDILSEYNGEIVAVKQGSFLACSFHPELTDDARLHQAFIKMVAERSVLEAH
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: UBE2N_RAT
Sequence: MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKSNEAQAIETARAWTRLYAMNNI
What is the function of this protein?
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains.  This type of polyubiquitination does not lead to protein degradation by the proteasome.  Mediates transcriptional activation of target genes.  Plays a role in the control of progress through the cell cycle and differentiation.  Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.  Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair.  Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.  Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.  Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity).  UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 N, Bendless-like ubiquitin-conjugating enzyme, E2 ubiquitin-conjugating enzyme N, Ubiquitin carrier protein N, Ubiquitin-protein ligase N.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: ANP8_MYOAE
Sequence: MDGETPAQKAARLAAAAAALAAKTAADAAAKAAAIAAAAA
What is the function of this protein?
Antifreeze proteins lower the blood freezing point.
What are the official names of this protein?
Ice-structuring protein GS-8, ISP GS-8, Antifreeze peptide GS-8.
What is the protein family that this protein belongs to?
Belongs to the type-I AFP family.
Protein: LIPA_DESRM
Sequence: MNKRKPDWLKIKLQGAEKSHEVKDMLKRLSLHTVCEEANCPNLIECFGRKTATFMILGSVCTRNCTFCNVTKGLTQAVDAEEPSNVAQAVKELGLKHVVITSVTRDDLPDGGAGHFAKVIEKLRPTEVIVEVLIPDFQGDREALDTVIRAKPHILNHNIETVPRLYATVRPKASYARSLELLKNSKELDPGIFTKSGIMVGLGEQEEEVIAVLQDLRAVDCDLLTIGQYLAPSAKHHPVIEYIHPELFKKYKDVAYEMGFKYVASDPLVRSSYHAADVSHIIG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_HAEIG
Sequence: MNKLALYCRPGFEKEVAAEITDQASHLGVFGFARVQDNSGYVIFECYQPDEADRLARDIPFNRLIFARQMIVISDLLEDLDPADRISPIVAAFEELSQQVNFAQSSELFVETADTNEAKELSTFCRKFTVPLRQALKKQGWLSAKASQKCGQFLHCFFVKPNCCYVGYSYVDNHSSHFMGIPRLKFPADAPSRSTLKLEEAILTFIPRKEENKRLNENMIGVDLGACPGGWTYQLVKRGLFVYAVDHGKMAANLHDTGRIEHCAEDGFKFQPPKRKKVDWLVCDMVEQPSRISSLIGKWLLNGWCRETIFNLKLPMKKRYQEVILCLENLAVMLAEQNLNFEIQAKHLYHDREEITVHIALKP
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGUL_MACFA
Sequence: MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPAMKFSLYFLAYEDKNDIPKDKEEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVHSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
What is the function of this protein?
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (By similarity).  Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).  Required for normal osteoclastogenesis (By similarity).
What are the official names of this protein?
Lactoylglutathione lyase, Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase.
What is the protein family that this protein belongs to?
Belongs to the glyoxalase I family.
Protein: RL30_FRATW
Sequence: MTQAKTFKVTLVKSLIGRKENHIASARGLGLRKINHTVEVLDTPENRGMANKIYYMVKIEG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: F174_XENLA
Sequence: MGVDGYVSLCSVGGMLLALLASSFISDGGCSVDAPTPSPAIPTGLASKKGSNSSTVDGGPLATVPSATSPNTPRTQRALVVLVLFSAAVVIYFVIRAVRTRIKNKKTRKYGVLDTNLGNMELTPLEQDDDDDDTLFDSNQPRSQLSLACILQTPQFPAHVISIRKGTSQCNALWVM
What are the official names of this protein?
Membrane protein FAM174, Transmembrane protein 157.
What is the protein family that this protein belongs to?
Belongs to the FAM174 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MMP15_MOUSE
Sequence: MGSDRSALGRPGCTGSCLSSRASLLPLLLVLLDCLGHGTASKDAEVYAAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQSFYGIPVTGVLDEETKTWMKRPRCGVPDQFGVHVKANLRRRRKRYTLTGKAWNNYHLTFSIQNYTEKLGWYNSMEAVRRAFQVWEQVTPLVFQEVSYDDIRLRRRAEADIMVLFASGFHGDSSPFDGVGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGISLFLVAVHELGHALGLEHSSNPSAIMAPFYQWMDTDNFQLPEDDLRGIQQLYGSPDGKPQPTRPLPTVRPRRPGRPDHQPPRPPQPPHPGGKPERPPKPGPPPQPRATERPDQYGPNICDGNFDTVAVLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGNISAAYERQDGHFVFFKGNRYWLFREANLEPGYPQPLSSYGTDIPYDRIDTAIWWEPTGHTFFFQADRYWRFNEETQHGDPGYPKPISVWQGIPTSPKGAFLSNDAAYTYFYKGTKYWKFNNERLRMEPGHPKSILRDFMGCQEHVEPRSRWPDVARPPFNPNGGAEPEADGDSKEENAGDKDEGSRVVVQMEEVVRTVNVVMVLVPLLLLLCILGLAFALVQMQRKGAPRMLLYCKRSLQEWV
What is the function of this protein?
Endopeptidase that degrades various components of the extracellular matrix.  May activate progelatinase A.
What are the official names of this protein?
Matrix metalloproteinase-15, MMP-15, Membrane-type matrix metalloproteinase 2, MT-MMP 2, MTMMP2, Membrane-type-2 matrix metalloproteinase, MT2-MMP, MT2MMP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein; Extracellular side.
Protein: DCEB_LISIN
Sequence: MLYSKENKESYLEPVFGSSAEDRDIPKYTLAKEPLEPRIAYRLVKDELLDEGSARQNLATFCQTYMEDEATKLMSETLEKNAIDKSEYPRTAELENRCVNIIADLWHAPKDQKFMGTSTIGSSEACMLGGMAMKFAWRKRAEKLGLDIYAQKPNLVISSGYQVCWEKFCVYWDIDMRVVPMDKDHMQLNTDQVLDYVDEYTIGVVGILGITYTGRYDDIYALNEKLEEYNSKTDYKVYIHVDAASGGFFTPFVEPDIIWDFRLKNVISINTSGHKYGLVYPGIGWVLWKDESYLPEELIFKVSYLGGEMPTMQINFSRSASHIIGQYYNFLRYGFEGYRTIHQKTSDVAQYLAHAVEQTGYFDIYNDGSHLPIVCYKLKDDANVKWTLYDLADRLQMRGWQVPAYPLPKNLENIIIQRYVCRADLGFNMAEEFIQDFQASIQELNNAHILFHDTQQSGVHGFTH
What is the function of this protein?
Converts internalized glutamate to GABA and increases the internal pH.  Involved in glutamate-dependent acid resistance in gastric fluid (By similarity).
What are the official names of this protein?
Glutamate decarboxylase beta, GAD-beta.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: CDC31_YEAST
Sequence: MSKNRSSLQSGPLNSELLEEQKQEIYEAFSLFDMNNDGFLDYHELKVAMKALGFELPKREILDLIDEYDSEGRHLMKYDDFYIVMGEKILKRDPLDEIKRAFQLFDDDHTGKISIKNLRRVAKELGETLTDEELRAMIEEFDLDGDGEINENEFIAICTDS
What is the function of this protein?
Functions as a component of the spindle pole body (SPB) half-bridge (PubMed:10684247, PubMed:11156974, PubMed:12486115, PubMed:14504268, PubMed:8070654).  At the SPB, it is recruited by KAR1 and MPS3 to the SPB half-bridge and involved in the initial steps of SPB duplication (PubMed:11156974, PubMed:12486115, PubMed:14504268, PubMed:8070654).  Also involved in connection with the protein kinase KIC1 in the maintenance of cell morphology and integrity (PubMed:9813095).  May play a role in vesicle-mediated transport, in a VPS13-dependent manner (PubMed:28122955).
What are the official names of this protein?
Cell division control protein 31, Nuclear pore protein CDC31, Nucleoporin CDC31.
What is the protein family that this protein belongs to?
Belongs to the centrin family.
What are the subcellular locations of this protein?
Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Spindle pole body, SPB half- bridge (PubMed:8188750). Interacts with the nuclear pore complex (NPCs) at the nucleus envelope (PubMed:10684247).
Protein: RNY_SALAI
Sequence: MSGFDAVLLVAVLLLALIVLGAVLVGVRAVRGIAGAPRPEDPAFIAEKDRQEQSLAALRSAADEANSTVDAAKSAAAAARTEAAAARAEAKAARAEARRVLDGARAEADTILERVHKQAEADAEQLRTAARRSGEREAAVLATTTREQAAEVERRAARMDDRERLHSEEVERLAERDRQLSAASAALAARESTLVDRDRELAQAEDRRRRELERVAGITAEAARGELVEAIEAQAKREAALLVREIESEARNTGEERARHIVVDAIQRVASEQTAESVVSVLHLPGDEMKGRIIGREGRNIRAFESVTGVNLIIDDTPEAVLLSCFDPVRREVGRLTLEKLVLDGRIHPHRIEEVHDLARQEVVQLCQRAAEDALVEVGITEIHPELVSLLGRLRYRTSYGQNVLKHLVETAHIAGIMAAELRLDVPTIKRCAFLHDIGKALTHEVEGSHAIVGADVARKYGESEDVVHAIEAHHNEVPPQTIEAVLTQASDACSGGRPGARRESLEAYVRRLERIEEIAAGKLGVERVFAMQAGREVRVMVRPEDVDDISASVLARDVAKQIEEELTYPGQIRVTVVRESRVTEIAR
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.