PharMolix/UniProtQA huggingface dataset:
Protein: STPAP_DANRE
Sequence: MELDKDIQTTQKGFHCNLCHVNIPNRPSLEDHVKGKKHLHLLRLRAQRKTQEENSVFVSGFKADTSQTELKEYFQQFGLVTDVIMDKQKGVYAIVEFSESQDVQTTLAQPQHQLNGLKLRVKPREKKEFKLASRGKQDCKNTLISLDKLNFELCKAMSVNEQIQKVVESLELKDNEKKVRDLLVQLLQEVFTEFFPDCQIVPFGSSVNTFGLHSCDLDLFLDLENTKVFQARAKSSEQTGENQSEDCRSEDSILSDIDLSTASPAEILELVAVILRKCVPGVHKVQALSTARLPVVKFSHKELNLQGDITINNRLAVRNTKFLQLCSGIDSRLRPLVYTIRLWAKQKQLAGNLSGPGPLLNNYALTLLVIFFLQNRDPPVLPSVNQLKNMACEEEECAIEEWDCTFPSQPFSVPPSKNTEDLCTLLFGFFTFYSKFDFPASVVSLRDGHVLPITDFLKSDMEALKTADASSPKPKRSSAPRLGPMNVLDPFELNHNVAGNLNERTQKNFKRECCEAEKYCRSLQYQRKSAKGKSWGLVRLFAPQSEAAASSQPRAEKVLEVSVPFKPASLPESLRAQLASAGKDFRGLWFAEVCSAVQKVFNEILQCSPTEETQSLDKTDKSGSEMEVNNNRSLEDTNIQVKGEAGKKRPLSVEEGPSTFTITQAKRQRLDVDLEHPEPLHWTWTQRSRVWAGRRKVRRDLLKTSDEASKPEGGCVDMESRVTQSIVEKEEKLHDALEFKVDAEVVGGNESTKVVLRFHPSIDTAGVFQDFFHFLESFLPKMAETIMGRAEDITDMS
What is the function of this protein?
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs.  In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs.  In addition to adenylyltransferase activity, also has uridylyltransferase activity.  However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase.
What are the official names of this protein?
Speckle targeted PIP5K1A-regulated poly(A) polymerase, Star-PAP, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus speckle.
Protein: MTAA_METBF
Sequence: MSEFTLKTRLLAALEGKPVDKVPVCSVTQTGIVELMDKVGAAWPEAHTNPELMAKLAIANYELSGLEAVRLPYCLTVLGEAMGCEINMGTKNRQPSVTASPYPKNLDGAVVPADLLQRNRIPAVLEAIKIVREKVGPDVPIIGGMEGPVTLASDLISVKSFMKWSIKKTDLFEQALDISAEAAIAYANAMVEAGADVIAIADPVASPDLMSPETFKQFLQSRLQKFSAGVNSVTVLHICGKVNAILSDMADCGFEGLSVEEKIGTAAEGKKIIGDRARLVGNISSPFTLLPGPIDKIKAEAKVALEGGIDVLAPGCGIAPMTPLENVKALVAARDEYYA
What is the function of this protein?
Methyltransferase involved in methanogenesis in the methanol pathway.  Catalyzes the transfer of the methyl group from the methylated corrinoid protein MtaC to coenzyme M, forming the substrate for coenzyme-B sulfoethylthiotransferase.  MtaC can be substituted by free cob(I)alamin in vitro.
What are the official names of this protein?
Methylcobamide:CoM methyltransferase MtaA, Methylcobalamin: Coenzyme M methyltransferase, [Methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily.
Protein: DNLJ_HYDCU
Sequence: MQDQKAYQKLVESLNQHSYQYYVLDDPIISDPQYDVLYQKLLRIEDEHPDWILPESPSQRIGDEPLKEFHTVRHAVPMYSLDNAFEDDELKSFLKRIEEKLPDQKSLAFSAEPKMDGLAINIRYENGQLVQATTRGDGQVGEDVTHNIRPIYSVPLKLFGNNWPEVVEVRGEVFMSKSAFEQLNEHQQEIGGKIFANPRNAAAGSLRQLDSKVAAKRHLSFFLYGWGELSDDWQLPQYYSEMIEQLVEWGLPANPQSEIISGLEGMFAYYEKIQAKRSELPYEIDGIVYKLNDIKLQQQLGFTARAPRWAIARKFPAEEVWTKLLDIEVQVGRTGAITPVARLQPVSVGGVIVSNATLHNMDEIKRKDVRIGDTVIVRRAGDVIPEVVGPILTQRPENTQLFEMPQHCPECGSDVVKELDKAVFRCTGGLVCPAQRKRALHHFVSRKAMDIQGLGDKLIDQLVDKGWVKHPDDFYHLTVEKLATLERMAEKSAQNVITGIQASLETTLAKFIYSLGIPEVGEVTAKNLANHFKDLNAIKQAEFEELITLNDVGEVVAEHIVNFFKEPHNESVIQGLLDAGMHWPTPETTLVNEDSPFANKVVVLTGTLSEMSRPEAKVLLEAQGAKITGSVSAKTDYVIAGEKAGSKLTKAESLGVAVLSEAEWLAMMPQQD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NADD_ROSCS
Sequence: MTSGRTGILGGSFDPIHYGHLAIAEEVRVLLRLNRVLIIPAREQPLKPGGSVASPAHRLAMARLACADNPFFEVSRIEIDRPDPSYTSVTLQLLHEQGLNDLYLILGIDSVADLPRWREVRRILELAHIVGVARPGAAVDLSHLSQVLPQLPARLIEIDGPRLDISSTDLRQRVAQGRPIRYQTPDAVVAYIEANGLYR
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: FOLD3_RUBXD
Sequence: MGARVIDGRPIAGELKKRVASEVEGLAARGVRPGLATVLVGEDYAARAYERRVGGLAAELGCRYVCERLPREAEEADVLAVVGKLNADPRVSGILVLRPLPGHISEPAVFSALDPLKDIEAVHPVNAGLLALGRPRYVPSTPAACFYLLDRYLERSGRPPEEFYPRSTVVVVGRSNNVGKPAVSLGFARGAAVISCDANAYRAGRLREHTLKADALIVAAGVAGLIDESYVREGVIAVDVGINPVADPGGSGRTLLVGDLDFGSVARKAEALTPVPGGVGPITDVWLLKNTVAAGRGLASQAKARCLLRGSHAHSSLI
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 3.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RS21_CLOBH
Sequence: MSEIKVGENESLENALRRFKKKCARAGVLSEVRKREHYEKPSVKKKKKSEAARKRKFK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RIMM_HAEDU
Sequence: MSEQKIEVVGKLGSTYGIRGWLRLYSSTEKAESIFDYQPWFLKIKGQWQLIELESWRYHSNDLIVKLKGTEDREAAQLLTNAEIGVDLSVFPKLGEEDYYWHDLINCQVVNLENYTMGVVTELMETGSNDVLVVRANSKDAFGKQERLIPFLYKQVVKRVDLSTKTITVDWDAGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEAL_SALCH
Sequence: MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLNTFFPWIEKQGLTVGIIILTIGVMAPIASGTLPPSTLIHSFVNWKSLVAIAVGVFVSWLGGRGITLMGNQPQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIVGKQ
What are the official names of this protein?
UPF0756 membrane protein YeaL.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUOI_SPHAL
Sequence: MSYVGHLVKSFTLWEFVKAHALTLKYFFKPKATINYPFEKNPLSPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIEAEPRDDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEYATETREELLYDKAKLLANGDKWERAIAANLAADAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PSD_COXB1
Sequence: MTKLHKYLPQRTLSKIVGWLATREWGLLTQWAIRLFIRHYGINMQEAQYPDIGHYPSFNAFFTRYLKRELRPVVEEPRAIASPVDGIISEMGQIKGENLIQAKNHHYTITALLGEDPSRASQFLDGDFFTAYLAPKNYHRIHMPLDGRLIEMIHIPGKLFSVNPASVQTVPRLFARNERAVCLFETENGLMAVILVGAMLVGSINTVWHGTVVPTAEGIAVHNYREKNIKFKRGEEIGHFKMGSTVILLFPKNTIQWNPNCQPKGTICYGENIGTVSLIEVA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NNRE_NEMVE
Sequence: MRYLNQSEAQNIDQELFNEYAFSVDQLMELAGLSVAVAISKAYPRTGDGERLLVCSGPGNNGGDGLVAARHLKMFGYQPEIYYPKRPNRTLMNNLVTQCEKMEISFLTDLPSAQEMNFKYRLVVDAIFGFSFKGEVRAPFDDVLKTLKNVKIPLCAVDVPSGWDVEKGNPEGIQPEFLISLTAPKLCANHFKGRFHYLGGRFVPDLLLKKYELELPDFPGTDPCVLLE
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
Protein: MLTF_ECODH
Sequence: MKKLKINYLFIGILALLLAVALWPSIPWFGKADNRIAAIQARGELRVSTIHTPLTYNEINGKPFGLDYELAKQFADYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYNSERVKNYQPGPTYYSVSQQLVYKVGQYRPRTLGNLTAEQLTVAPGHVVVNDLQTLKETKFPELSWKVDDKKGSAELMEDVIEGKLDYTIADSVAISLFQRVHPELAVALDITDEQPVTWFSPLDGDNTLSAALLDFFNEMNEDGTLARIEEKYLGHGDDFDYVDTRTFLRAVDAVLPQLKPLFEKYAEEIDWRLLAAIAYQESHWDAQATSPTGVRGMMMLTKNTAQSLGITDRTDAEQSISGGVRYLQDMMSKVPESVPENERIWFALAAYNMGYAHMLDARALTAKTKGNPDSWADVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQATEAAMQLAQDYPAVSPTELGKEKFPFLSFLSQSSSNYLTHSPSLLFSRKGSEEKQN
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: COBQ_RHILW
Sequence: MARAIMLQGTGSDVGKTVLVAGLCRLAANRGLAVRPFKPQNMSNNAAVADDGGEIGRAQWLQSLAARAPSSVHMNPVLLKPQSENGSQIIVQGRVFGQSKGRDYQRLKPQLLGAVLESFEKVAAGADLVIVEGAGSPAEINLRAGDIANMGFATRAGVPVVLVGDIDRGGVIASLVGTHAILDDGDRAMIAGYIINKFRGDISLFDDGIRAIEGFTGWPCFGVVPWLPGAARLPAEDSVVLERLAKGRAGALKIAVPVLPRIANFDDLDPLRAEPDVELVFVRSGERLPADASLVILPGSKSTISDLADFRAEGWDRDLHMHVRRGGRVIGICGGYQMLGRTVRDRLGIEGGTLETPGLALLDVETEMAPEKTVRNSHARSTEYDVPLAGYQIHLGITHGPDCDRPSAIVDGVPDGALSADGRIVGTYLHGLFGSDAYRTRLLQSFGLSGERRNYRESVEQALDEIAGELERYLDPRWLAGLLG
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: DED1_CRYNJ
Sequence: MAATDVNGLASQMNSVNLNGASQKPQKPAYVPPHLRNRAAPPAAVPPAAPAAYRPSPTGLPTPATTPPTRHIVPAAVAEDDVGGWGAQPRVRKTFEHGAPPGFGSWKNGQHVVGARNTRMEKEMYGEVGDGLHQATGINFDKYADIPVEVSGKGVPEPVTEFTNPPINPVLLENVKYARYATPTPVQKYSIPIVADGRDLMACAQTGSGKTGGFLFPILSALFTYGPSTPPVEQDTGYGYRRTKKVYPTALVLAPTRELVSQIHEEARKFAYRSWVRPAVVYGGADIGSQMRALDRGCDLLSATPGRLVDLIERGKISLANVKYLVLDEADRMLDMGFEPQIRRIVDEEDMPGVLERQTLMFSATFPREIQNLARSFLKEYIFLTVGRVGSTSENITQRVEYVDDQDKRSLLLDLLLAEQSGGLILVFVETKRMADTLCDFLCSRRHNATSIHGDRTQREREAALYAFKSGRAPILVATAVAARGLDIPNVTHVILYDLPNDVAEYTHRIGRTGRAGNVGTSTAFFNRGNTNIGKDLIELLKEANQEVPQWLVEISSERSYGGGGGGGYKGSRGRSTGGGGGARLGGRDMRQGGGGYGGGGRTSGYGGGYGGGGGGAGWGSGGGFPPAGGDSGASWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase ded1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP30_EBOSU
Sequence: MERGRERGRSRNSRADQQNSTGPQFRTRSISRDKTTTDYRSSRSTSQVRVPTVFHKKGTGTLTVPPAPKDVCPTLRKGFLCDSNFCKKDHQLESLTDRELLLLIARKTCGSTDSSLNIAAPKDLRLANPTADDFKQDGSPKLTLKLLVETAEFWANQNINEVDDAKLRALLTLSAVLVRKFSKSQLSQLCESHLRRENLGQDQAESVLEVYQRLHSDKGGAFEAALWQQWDRQSLTMFISAFLHVALQLSCESSTVVISGLRLLAPPSVNEGLPPAPGEYTWSEDSTT
What is the function of this protein?
Multifunctional protein that acts as a viral transcriptional activator.  Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription.  Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA.  Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures.  Assists also stop-start transcription at gene junctions to promote transcription of downstream genes.  Interaction with NP plays a critical role in transcription initiation by recognizing the RNA stem loop (By similarity).  Interaction with host RBBP6 interferes with NP-VP30 interaction and inhibits viral RNA synthesis.  Also acts as a suppressor of RNA silencing by interacting with host DICER1 and TARBP2/TRBP (By similarity).
What are the official names of this protein?
Transcriptional activator VP30, EbolaVP30, eVP30, Minor nucleoprotein VP30.
What is the protein family that this protein belongs to?
Belongs to the filoviridae transcriptional activator VP30 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Present in viral inclusion bodies due to its interaction with NP.
Protein: RL17_BARBK
Sequence: MRHGKSGRKLNRTTSHRKAMFANMAASLIEHEQIVTTLPKAKEIRPIVEKLVTLGKRGDLHARRQAIAAIRDTEKVAKLFSALAPRYESRHGGYLRIMKAGFRTGDNAPMAVVEFVDRDVNAKGATDHERKVAKVTEKEDS
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: IXTPA_STRMU
Sequence: MKEKIYEYKDDHNWFISQWSKVGSSTYYEEEAEETYSSIEQSLRGLLDEGNSFILTVIKINSNIALVRFILKMLNEEQQDNFKVSSHKGAILVTQGQQLLLVCLPKKGITITDFFEKEKKVSELGDTILIATRNEGKTKEFSQMFAQLGIKVENLNQYPDLPEVEETGLTFEENARLKAETISHLTGQMVLADDSGLKVDVLGGLPGIWSARFSGLDATDQSNNAKLLHELAMVFDIKDRSAQFHTTLVVAAPDKESLVVEADWSGYIDFAPKGNNGFGYDPLFLVGETGKTAAELSNHEKNIISHRGQAVKKLMEVFPAWQNAH
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: TILS_RHIME
Sequence: MPHAVLDTARNFLRSFITPRRILVAVSGGSDSMGLLVALHSAIAADERRGFSLAACTVDHALRPQSACEAEDVAAFCAALGIAHRICRWEGAKPSTGIQAAARNKRYELLAEAADALGADCIAIGHTRDDQQETVAMRIARGKGDGAGDGQGEGHGGAGMAASMLYGRRIWVLRPFLGLARAEIRSFLQARGVSWIDDPSNANPAFERVRVRARIATSGGMPTPLGNGRQRAASSARAAALIEKRIRVHEALVAEVSARHAGEIDDPDWRRALLTVASVLGGREHMPAFATVQRLSQFLRSGEPGRMTAGRVVFDRRASGLYLYREARNLPVLAVGPGRQGAWDGRFTVKSRGPAVTVAADASGRLWTKRLIDAGLPAGIAKRGSTVAPEIASTDGAGLAFGEAPAQVEYHIGLYDTFLPGFDRIMADAVAVSFGRDRYPAPPVHDVLIEMET
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRAM2_HUMAN
Sequence: MAFRRRTKSYPLFSQEFVIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPTADSETVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQKVRKEEIPRQLQYICLYLVHIAGAYLLNLSRLGLILLLLQYSTEFLFHTARLFYFADENNEKLFSAWAAVFGVTRLFILTLAVLAIGFGLARMENQAFDPEKGNFNTLFCRLCVLLLVCAAQAWLMWRFIHSQLRHWREYWNEQSAKRRVPATPRLPARLIKRESGYHENGVVKAENGTSPRTKKLKSP
What is the function of this protein?
Necessary for collagen type I synthesis.  May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon.  This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.  Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).
What are the official names of this protein?
Translocating chain-associated membrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the TRAM family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: EIF3E_ASPOR
Sequence: MAANVPPSAETLLSGAAAHPPKTAEEIANQYDLLPKLIPFLDRHLVFPLLEFSSGQDDDKEIVRAKYELLKHTNMTDYVANLWQEINNSDTIPDEFVKKREEVLAKLQHYQEESAKITELLQDEDVVGNLRSDKVANLKFLEEQHGVTPEMVNSLFDYGRFQYSCGSYGNAAELLYQFRVLSTDNDKVASATWGKLASEILTTSWEAAMEEVQKAKESIETRLFNNPLGQLQNRSWLIHWSLFPFFNYDPARDVLTDLFFSPAYINTIQTHCPWILRYLAAAVITNRGRAHKSSSLYQKQLKDLIRVVRQEGYEYSDPITDFVKALYIDFDFEEAQKKLGEAEDVLRSDFFLVSAADAFVEAARHLISESYCKIHQRIDIKDLSTRLGLNQDEGEKWIVNLIRDTRVDAKIDYKEGTVIMNHPPQSVYQQVIEKTKGAFFRTQVLSAAVAK
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, eIF3e.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_SHEON
Sequence: MTRVALTSAVNLAKKLQDAGIRNPAVLKAISQTPRELFLDNALAHKAYENTALPIGQGQTISQPYIVARMTELLLQHQPQKVLEVGTGSGYQAAILAQLVPELCTVERIKALQIQARQRLKRLDLHNVSFKYGDGWQGWLNRSPYNGIMVTAAAAKIPEALLSQLAEGGVLIIPVGEETQQLMRITRHSDRFSSEVIETVKFVPLVNGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_KOSOT
Sequence: MWSDPIADMLTRIRNANAAFKESVDLPASNMKRAILEILKKEGYIEDYKYIEDGKQGILKVFLKYKGDRRNRQRVISGIVRVSKPGRRIYVSKDELPKVKSGMGIAVISTSKGIITDKEARKKNVGGEVICYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: VG40_ICHVA
Sequence: MTPVPPSSLRSIAPLSTVFLFTDNVRSNSWFVCKIVYRCLSPRRIISPSICTAFSCWANHGLRLSSTAAMRRSSSSTFLFMASTRMSSSTFVCFIFVFCVSRTAMVFWSFSESTSLLWCIISSSMRLCFSITSGST
What are the official names of this protein?
Uncharacterized protein ORF40.
Protein: RL13_BACCQ
Sequence: MRTTFMAKANEVERKWYVVDAEGQTLGRLASEVASILRGKNKPTFTPHVDTGDHVIIINAEKIHLTGNKLNDKIYYRHTNHPGGLKQRTALEMRTNYPVQMLELAIKGMLPKGRLGRQVSKKLNVYAGAEHPHQAQKPEVYELRG
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ATG15_USTMA
Sequence: MRASTHSWLLLVVVLSLSSFTVNAVILEGLIPPRSHLAPSTFQQPFALSSYLQKLFGTSLRALYGAEQNRQTSVKTFGLREAYHQGIGDKAHERARATFDFRITANDVQADQANIDFIPAIRTVRQRITRAKDPKKYVEVRGQSYRDAMCAASTELDWEDVDVEAPDVTERTTVLAFAKMASAAYKNDTSDWDGIGGFDPTNSFGWEGDGIRGHIFTTHDNDTIVVALKGTSNVFLGGGDTARRDKTNDNLLFSCCCARVSWSWSTVCDCYQGHGDQCGQTCVERALIEKSLYYPAITDLFNNVSYAYPDSQIWITGHSLGGALSSLLGMTFGVPTVTFQAPGERMAAMRLHLPLPPAKHADESPVAALPIVHVYNNADPIATGTCNGAASVCSNFGYAMESKCHSGKSIVYDTVGKLGWSMTINAHRINTLVDDVLTEDWSEKVRKKKAKLRSIGSRGGQISTRGWRWPWHRGDSADDDGDSDEDTDEDDKLAVPKARSEERCQDCTNWHFTDETL
What is the function of this protein?
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies.  Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.  The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
What are the official names of this protein?
Putative lipase ATG15, Autophagy-related protein 15.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).