PharMolix/UniProtQA huggingface dataset:
Protein: SMD_AJECG
Sequence: MTPLLRTICAILCILIAVPLTFACPTKAGVSKQANKRPTYAIAHMVLDRKGLKDAIKNGANSVEIDIAAYKEGWWADHDIRGRSWGDSLEDMFKAVAKESKNIAFVWLDLKTPDMCSGATCNKDVLDPSKCKPKDKCSMNSLQELAQKILNPAGVRILYGFFGAGATDSAGFNYIQGNLKAGEAVCLSGEVENVLNVYKKKGRGVKPQQRVMDYGYTQLETGFGNCKEKGYNTCAGLRNGAKARDKGDVKRVFGWTSRVGDGERVGQLLDKAHVDGIIYGFAITRYYDHEDSRAAARDITQRVQKSDDRYMATGADKPW
What is the function of this protein?
Catalyzes the hydrolysis of sphingomyelin.  Sphingomyelinases D are produced by some spider in their venoms, but also by arthropods such as ticks, or pathogenic bacteria and fungi.  They might play a role in pathogenicity through different mechanisms, such as membrane destabilization and host cell penetration, but also pulmonary inflammation and cutaneous lesions.
What are the official names of this protein?
Sphingomyelinase D, SMase D.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelinase D/phospholipase D family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS19_PHYMT
Sequence: MPRSVKKGPFYDNHLLVKVLKQKDLKNKKVIKTWSRRSTILPQFRGNTFAVYNGRVHIPVYINEDMVGHKLGEFSPTRTYRGHDKKDKKIQKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: HUTU_CAUSK
Sequence: MTRLDNTRVIRPATGTELTAKSWLTEAPLRMLMNNLHPDVAERPEELVVYGGIGRAARDWESYDKIVETLRRLEDDETLLVQSGKPVGVFKTHPDAPRVLIANSNLVPRWATWEHFNELDRKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHHGGDLAGKWLLTAGLGGMGGAQPLAAVMAGASCLAIECQPSRIEMRLRTGYLDKATERLDEALAWIAEANAAKAPVSVGLLGNAAELLPAMFAAGVRPDLLTDQTSAHDPINGYLPAGWTLDQWATAKEREPETVNRAARASMAVHVQAMLDFQAAGVPTVDYGNNIRQMALEEGVKNAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIAKTDAKVKELIPDNPHLHHWLDMAAEKIKFQGLPARICWVGLGDRHRLGLAFNAMVASGELKAPVVIGRDHLDSGSVASPNRETEAMMDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHAGMVIVADGTEAAAKRLARVLWNDPASGVMRHADAGYEIAKACAREHGLDLPGIL
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIPSN_DICDI
Sequence: MNNFRNLINQSIRNYSTTTNVATKTKVYELKTYNILANNIPSFFELLGENKGSNSLGTWVTEMGSSNQVISLVEHESLDDRQMNEWNTKFQSKAAKLIEKQESLILREFPWAPFQKISNEKSNENKVWELRTYQSKPGKLGQWAIDFTTGFAERKKISEPVGVFYSEFGPLNTIVHLWPYKSFEDRFRIRDLALKNPVWVETVAKTTANLDSMESKTIIPVKL
What are the official names of this protein?
Protein NipSnap homolog.
What is the protein family that this protein belongs to?
Belongs to the NipSnap family.
Protein: MEND_MYCA9
Sequence: MNPSTAQAHAVVDELIRGGVRDVVLCPGSRNAPLAFALHDADKAGRLRLHVRIDERTAGFLAVGLAAASGSPVPVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRAAISIGLAEEGSEKIEAQNPHWRSATCRVLAAAKGSRTANAGPVQFDIPLREPLVPDRDGGPIPAGRPGGAPWTYTPDVTFDEPVEIDLTADTVVIAGHGAATHPNLSMLPTVAEPTAPQPDNPVHPLALTLLHPQQVIMLGRPTLHRQVSSLLADSRIPVYALTTGPRWPDVSGNSQATGTRAVTSGSPDPAWLQRCAHAHHKALDAVRGQLSTHPLTTGLHVAAHVCGSLRDGDQLVLGASNPVRDAALVPWGAKDVRVRSNRGVAGIDGTVSTAIGAALAHRGGRTVALIGDLTFVHDSSGLLIGPTEPRPENLTIVVSNDNGGGIFELLEQGDPRFHDVSSRIFGTPHDVDIAALCRAYHVDSQSISVEELGPALDEPARGIRVLEVKADRSTLRELHAAIRAAL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: HYLS1_MOUSE
Sequence: MAEKRQAYSVPEAMKQLIGPGGQKWANMDPEERMLAAATAFTRICAGQGEGDSRREAQAGQYDPYSKASVTPGKRPALPMHLHFPHTASRVTSSTVSETSQKCRKPVMKRKVLRRKPDGEVLVTDESVISECESGTESDLGLWDLRHRFMNLQFQEGTESPVVTSQKFNLPCEYQGISQEDQLICYLQREEMDPPVYEQDLIVASRPKSFILPRLDQLSRNRGKIDRVARYFEYKRDWDSMRFPGEDHRKELRWSVRGQMLSRTEPPSKPQHVYVPNNYLVPLRWGVRCDLANGVMPKKLPFPLSPS
What is the function of this protein?
Plays a role in ciliogenesis.
What are the official names of this protein?
Centriolar and ciliogenesis-associated protein HYLS1, Hydrolethalus syndrome protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the HYLS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: KAD_MICLU
Sequence: MTRMLLMGPPGSGKGTQATRIADKLGIVPISTGDIFRHNVKSMTPLGVEAKRYIDNGDFVPDEVTNRMVADRIAQADAEHGFLLDGYPRTKGQVEALDAMLAEAGQSLSAVVELEVPDEELVERLLKRAEIEGRADDTQEVIEHRLDLYHRETESVIQEYVERGIVARVDGTGQIDDVTERLLQAVYSVRSATGSLPVIQPGAES
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_MYCLE
Sequence: MFASDGNAATQWMPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFHAVSLVDQVTVRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAKLGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVYTEFDRLRDVGNPPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSLDPALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHAPMSRGLNDM
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: Y1739_STAAM
Sequence: MDWILPIAGIIAAIAFLILCIGIVAVLNSVKKNLDYVAKTLDGVEGQVQGITRETTDLLHKVNRLTEDIQGKVDRLNSVVDAVKGIGDSVQTLNSSVDRVTNSITHNISQNEDKISQVVQWSNVAMEIADKWQNRHYRRGSANYKANNVATDANHSYTSRVDK
What are the official names of this protein?
UPF0478 protein SAV1739.
What is the protein family that this protein belongs to?
Belongs to the UPF0478 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SCPB_STRP2
Sequence: MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQKYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQPITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHLEELPVIDELEIQAQESQLFGERIEEDENQ
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: Y1312_MYCTO
Sequence: MSAPMIGMVVLVVVLGLAVLALSYRLWKLRQGGTAGIMRDIPAVGGHGWRHGVIRYRGGEAAFYRLSSLRLWPDRRLSRRGVEIISRRAPRGDEFDIMTDEIVVVELCDSTQDRRVGYEIALDRGALTAFLSWLESRPSPRARRRSM
What are the official names of this protein?
Uncharacterized protein MT1352.
What is the protein family that this protein belongs to?
To M.leprae ML1147.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DAPD_SALPC
Sequence: MQQLQNVIETAFERRADITPANVDTVTREAVKQVISLLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIDGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYLGQSTKIYDRETGEVHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_BORBZ
Sequence: MSKLKEKREKAVVGIERASKEEAIELARVQIEKAFGKGSLIKMGESPVGQGIKSMSSGSIVLDEALGIGGYPRGRIIEIFGPESSGKTTLTLQAIAEVQKEGGIAAFIDAEHALDPVYAKALGVNVAELWLSQPDTGEQALEIAEHLIRSGGVDLIVVDSVAALTPKLEIDGEMGDSQIGLQARLMSKALRKITGILSKSNTCIMFINQIRMRIGVMFGNPETTTGGNALKFYSSLRLEVRKIEQVTRSGSSDDVIGNKIRVKIVKNKVAPPFRKVELIIYFGKGISREAGILDAAIKHNLIQKTGSWYSLGDNKLGQGRESVIEYLSKEVELANNLDKRLRKIIFNNFDQENDNFIEFKEDESE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BXF_CLOBO
Sequence: MPVAINSFNYNDPVNDDTILYMQIPYEEKSKKYYKAFEIMRNVWIIPERNTIGTNPSDFDPPASLKNGSSAYYDPNYLTTDAEKDRYLKTTIKLFKRINSNPAGKVLLQEISYAKPYLGNDHTPIDEFSPVTRTTSVNIKLSTNVESSMLLNLLVLGAGPDIFESCCYPVRKLIDPDVVYDPSNYGFGSINIVTFSPEYEYTFNDISGGHNSSTESFIADPAISLAHELIHALHGLYGARGVTYEETIEVKQAPLMIAEKPIRLEEFLTFGGQDLNIITSAMKEKIYNNLLANYEKIATRLSEVNSAPPEYDINEYKDYFQWKYGLDKNADGSYTVNENKFNEIYKKLYSFTESDLANKFKVKCRNTYFIKYEFLKVPNLLDDDIYTVSEGFNIGNLAVNNRGQSIKLNPKIIDSIPDKGLVEKIVKFCKSVIPRKGTKAPPRLCIRVNNSELFFVASESSYNENDINTPKEIDDTTNLNNNYRNNLDEVILDYNSQTIPQISNRTLNTLVQDNSYVPRYDSNGTSEIEEYDVVDFNVFFYLHAQKVPEGETNISLTSSIDTALLEESKDIFFSSEFIDTINKPVNAALFIDWISKVIRDFTTEATQKSTVDKIADISLIVPYVGLALNIIIEAEKGNFEEAFELLGVGILLEFVPELTIPVILVFTIKSYIDSYENKNKAIKAINNSLIEREAKWKEIYSWIVSNWLTRINTQFNKRKEQMYQALQNQVDAIKTAIEYKYNNYTSDEKNRLESEYNINNIEEELNKKVSLAMKNIERFMTESSISYLMKLINEAKVGKLKKYDNHVKSDLLNYILDHRSILGEQTNELSDLVTSTLNSSIPFELSSYTNDKILIIYFNRLYKKIKDSSILDMRYENNKFIDISGYGSNISINGNVYIYSTNRNQFGIYNSRLSEVNIAQNNDIIYNSRYQNFSISFWVRIPKHYKPMNHNREYTIINCMGNNNSGWKISLRTVRDCEIIWTLQDTSGNKENLIFRYEELNRISNYINKWIFVTITNNRLGNSRIYINGNLIVEKSISNLGDIHVSDNILFKIVGCDDETYVGIRYFKVFNTELDKTEIETLYSNEPDPSILKNYWGNYLLYNKKYYLFNLLRKDKYITLNSGILNINQQRGVTEGSVFLNYKLYEGVEVIIRKNGPIDISNTDNFVRKNDLAYINVVDRGVEYRLYADTKSEKEKIIRTSNLNDSLGQIIVMDSIGNNCTMNFQNNNGSNIGLLGFHSNNLVASSWYYNNIRRNTSSNGCFWSSISKENGWKE
What is the function of this protein?
Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of light chain (LC) into host cytosol.  Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD).  The RBD is responsible for the adherence of the toxin to the cell surface.  It simultaneously recognizes 2 coreceptors; polysialated gangliosides and the receptor protein SV2A, SV2B and SV2C in close proximity on host synaptic vesicles; although not all evidence indicates these are the receptors (By similarity).  The N-terminus of the TD wraps an extended belt around the perimeter of the LC, protecting Zn(2+) in the active site; it may also prevent premature LC dissociation from the translocation channel and protect toxin prior to translocation (By similarity).  The TD inserts into synaptic vesicle membrane to allow translocation into the host cytosol (By similarity).
What are the official names of this protein?
Botulinum neurotoxin type F, BoNT/F, Bontoxilysin-F.
What is the protein family that this protein belongs to?
Belongs to the peptidase M27 family.
What are the subcellular locations of this protein?
[Botulinum neurotoxin type F]: Secreted. SUBCELLULAR LOCATION: [Botulinum neurotoxin F light chain]: Secreted. Host cytoplasm, host cytosol. SUBCELLULAR LOCATION: [Botulinum neurotoxin F heavy chain]: Secreted. Host synapse, host presynaptic cell membrane. Host cytoplasmic vesicle, host secretory vesicle, host synaptic vesicle membrane; Multi-pass membrane protein.
Protein: RS7_NOSP7
Sequence: MSRRGVIQRRPVPSDSVYNSRLVSMIIRRIMRHGKKSLAARIVYEALKTIEERTGNGALETFERAVRNATPLVEVKARRVGGATYQVPMEVRSERGTTLALRWLVQYSRSRPGRTMASKLANELMDAANETGNAIRKREETHRMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: YG55_YEAST
Sequence: MVQAVSDNLISNAWVISCNPLALEVPERIGSTYFCFGGAIFILVAPLTNLVYNEDIVSQTRLYIYYRGSRDSRACMLDIVTLVDVSKRSKLVLLLQIYFFSF
What are the official names of this protein?
Putative uncharacterized protein YGR242W.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IDI2_CHLPM
Sequence: MSTTITNSTAERKHSHVDICLRGDVAFSTITTGLERYRLRHNALPELNYDNLSTETDFLGKRIGAPLMISSMTGGYSEAAELNGKLAEAAERFQLPLGVGSMRQALEESSHRDSFAVVRRHAPTTQIFANIGAPEIAKGLSSDDLQTMIEMIRADGLIIHLNAAQELFQPEGGTDFRRVLDEVAAITAKLSVPVIAKEVGCGISAPVARQLLNAGVRVIDVAGAGGISWQKVEEARYTRRFGTDDRFSTRGLEELLNWGTPTAECLVAVNALRENPTPPFSLIASGGIQSGIDIAKSIALGADLAASAGALLRSLHSGTLEETLTTWMNDLRAAMFLTGSATIAELQNNRPISKQ
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBZ_THEVL
Sequence: MTILFQLALAALVILSFVMVIGVPVAYASPQDWDRSKQLIFLGSGLWIALVLVVGVLNFFVV
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.  PSII is a light-driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: ARGC_RHILO
Sequence: MKPKIFIDGEHGTTGLQIRALLAERGDLEIISIPTERRKETAARAEFLNAADIAILCLPDDAAKESVSLITNDTTKVIDASTAHRVAEGWAYGFAEMDKEQAKAIATAKRVANPGCWPQGPIATLRPLVTSGLLPADFPITVNGISGYSGGGRPMIEDYVAKGEDASEFLPYGLTLQHKHVPELRAYAKLSHDPIMQPAVGNFAQGMITVVPLQLGGLDSVPTGAELHAAIADHFAAIKGGVVEVAPYAHLERMPEIDPEIYNGTNRMKVYVFANDKRAQALLLAVYDNLGKGASGAAVQNMDLMLGL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPS1_ARATH
Sequence: MYMIESKGGAIACMLLALLFLGTWPAIMTLTERRGRLPQHTYLDYTLTNLLAAVIIALTLGEIGPSRPNFFTQLSQDNWQSVMFAMAGGIVLSLGNLATQYAWAYVGLSVTEVITASITVVIGTTLNYFLDDRINRAEVLFPGVACFLIAVCFGSAVHKSNAADNKTKLQNFKSLETTSSFEMETISASNGLTKGKAKEGTAAFLIELEKQRAIKVFGKSTIIGLVITFFAGICFSLFSPAFNLATNDQWHTLKHGVPKLNVYTAFFYFSISAFVVALILNIRFLYWPILGLPRSSFKAYLNDWNGRGWSFLAGFLCGFGNGLQFMGGQAAGYAAADAVQALPLVSTFWGILLFGEYRRSSRKTYTLLISMLLMFIVAVAVLMASSGHRK
What is the function of this protein?
Proton-coupled transporter that transports a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, uric acid and xanthine, but not adenine (PubMed:11971139, PubMed:15308648).  Mediates high affinity transport of uracil and 5-fluorouracil (a toxic uracil analog) (PubMed:15308648, PubMed:16897711).  Mediates transport of free pyrimidines and may function during early seedling development in salvage pathways, by the utilization of pyrimidines from seed storage tissue (PubMed:15308648).
What are the official names of this protein?
Ureide permease 1, AtUPS1.
What is the protein family that this protein belongs to?
Belongs to the plant ureide permease (TC 2.A.7.19) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ISPG_GLUOX
Sequence: MSSYRPYQHIERRKSRQIHVGKVAVGGDAPISVQTMTNTLTSDAQATIEQIRRAELAGVDIVRVSCPDEASTAALEEIVREVNVPIVADIHFHYKRAIEAAKAGAACLRINPGNIGSAERVREVVNAARDYGCSIRIGVNAGSLEKHLLEKYGEPNPEALVESALEHAKILEDHDFHEFKISVKASDVFMAVAAYQQLADCCDHPLHIGITEAGSKRAGTVKSSIGLGNLLWAGVGDTMRVSLSAAPEEEVLVGWDILKSLGLRHRGVKIISCPSCARQGFNVVETVQTLEDRLQHIKTPLTLSIIGCVVNGPGEALMTDIGVTGGGNGRHMVYAAGRQDHTMPAGDMIEHIVELVEKKVSDIEAGKVEASTAKQMDPAAS
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: QUEF_ACTPJ
Sequence: MNYNDKSLSALKLGQKTEYKSEYDPTLLQPVPRKLNRDGLGITEQQPFDRGADVWTCYELSWLNENGLPQVAIADVAIDFRSENLIESKSFKLYLNSFNQTKFASLEQVEQALAKDLSQCASGQVSVKVYKLSAYTRQPIVDFAGECIDEQDIQIDSYEFSNEHLASVAEGEIVEETLVSHLLKSNCLITSQPDWGSVQIHYIGKKLNREKLLRYLVSFREHNEFHEQCVERIFTDLIQFTQPEKLTVYARYTRRGGLDINPFRSNFEAVPQNLRMARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOAT1_RAT
Sequence: MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
What is the function of this protein?
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol.  Plays a role in lipoprotein assembly and dietary cholesterol absorption.  Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrateb a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions.
What are the official names of this protein?
Sterol O-acyltransferase 1, Acyl-coenzyme A:cholesterol acyltransferase 1, ACAT-1, Cholesterol acyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ACCA_LEGPH
Sequence: MTRQFLEFEQPIEELNQKIEALRMVGSDNEVNLSEEIARLEAKCSELTENIFSRLEPWQIAQMARHPLRPQTTDYIERIFTDFQELHGDRSYSSAPAIIGGMARLNGEPVMVLGHQKGKRTKEKVYRNFGMARPEEYRKALRLMRMAEKFKMPVVTFIDTAGAYPGIGAEERNQSEAIARNLFAMSRIKTPIVCIVTGEAGSGGALAIGVGDKIIMLQFSIYSVISPEGCASILWKDASKASEAARAMGITADRIFENELVDMVVPEPLGGAHRDVDEMASRLKRLLTSELQALKKVPLDQLIELRYQKFMAMGACD
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P5I11_HUMAN
Sequence: MAAKQPPPLMKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFTIREPLGLRVWQFVSAVLFSGIAIMALAFPDQLYDAVFDGAQVTSKTPIRLYGGALLSISLIMWNALYTAEKVIIRWTLLTEACYFGVQFLVVTATLAETGLMSLGILLLLVSRLLFVVISIYYYYQVGRRPKKA
What are the official names of this protein?
Tumor protein p53-inducible protein 11, p53-induced gene 11 protein.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: G6PI_ARAHG
Sequence: MASSTALFCDTEAWKDLKGHVEDIKKTHLRDLMSDANRCQSMMMEFDGLLLDYSRQRAPVETMDKLLNLAKAAQLTEKISRMFNGEHINSTENRSVLHVALRAPKDAVIKADGKNVVPEVWNVLDKIKEFSEKIRSGSWVGATGKPLKDVIAIGIGGSFLGPLFVHTALQTDPEALESAKGRQLRFLANIDPVDVARNIKGLNPETTLVVVVSKTFTTAETMLNARTLREWITAALGASAVAKHMVAVSTNLALVEKFGIDPNNAFAFWDWVGGRYSVCSAVGVLPLSLQYGFSVVEKFLKGASSIDQHFQSTPFEKNIPVLLGLLSVWNVSFLGYPARAILPYSQALEKFAPHIQQVSMESNGKGVSIDGLPLPFETGEVDFGEPGTNGQHSFYQLIHQGRVIPCDFIGIVKSQQPVYLKGEVVSNHDELMSNFFAQPDALAYGKTPEQLQKENVSENLIPHKTFSGNRPSLSLLLPELTAYNVGQLLAIYEHRVAVQGFVWGINSFDQWGVELGKVLATQVRKQLHSSRTQGTALEGFNYSTTTLLKRYLETSSEPQM
What are the official names of this protein?
Glucose-6-phosphate isomerase, cytosolic, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_ECOSE
Sequence: MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.