PharMolix/UniProtQA huggingface dataset:
Protein: DER_CUPPJ
Sequence: MKPVIALVGRPNVGKSTLFNRMTRSRDALVADLPGLTRDRHYGEGRIGDRPFIAIDTGGFEPVVKEGIVAEMAKQTRQAVVEADVVIFIVDGRLGLAPQDRAIADYLRKTGRRVMLAVNKAEGMKYTSVAADFYELGMGDPYAISAAHGDGVRELVDEALELAVQERPELAEEDADSGKGVKIAIVGRPNVGKSTLVNTLIGEERVIAFDMPGTTRDAIYVEFERGGKPYTLIDTAGLRRRGKVFEAIEKFSVVKTLQSIADANVVILLLDAQQDISDQDAHIAGFIVESGRALVVGVNKWDGLDGHTRDRIKHDLERKLQFLSFANFHFVSARERTGIGALMRSVDDAYAAAMVKLPTPQLTRVLQEAVEFQQPKRAGVSRPKLRYAHQGGSNPPIIVIHGNALSSVSETYRRYLENRYRAAFKLKGTPLRIEFRTNKNPYADSKD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: GET1_AJECG
Sequence: MPSLLITVLFLNVIIYVVNTVGAATVDGLLWLLYIQLPTGTSQIAREQRHMKREVVQLKHEMSSTSSQDEFAKWAKLRRRHDKALEAYEAKNNELTQSKSTFDMTIKIARWAATSGLMLFLQFWYSKTPIFTLPPGWIPWQVQWVLSFPRAPMGTVSIQIWGGACATVVALVGDAMKASLAYVSKPKIDRIKLGATMEGKEGKKRQ
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein GET1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TAF1D_PONAB
Sequence: MDKSGIDSLDHVTSDAVELANRSDNSSDSRLFKTQCIPYSPKREKRNPIRKFVRTPESVHASDSSSDSSFEPIPLTMKAIFERFKNRKKRYKKKKKKRYQPTGRPRGRPEGRRNPIYSLIDKKKQFRSRGSGFPFLESENEKNPPWRKILTFEQAVARGFFNYIEKLKYEHHLKESLKQMNVGEDLENEDFDSRRYKFLDDDGSISPIEESTAEDEDATHLEDNECDIKLAGDSFIVSSEFPVRLSVYLEEEDITEEAALSKKRATKAKNTGQRGLKM
What is the function of this protein?
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription.  The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter.  SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.  Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).
What are the official names of this protein?
TATA box-binding protein-associated factor RNA polymerase I subunit D, TATA box-binding protein-associated factor 1D, TBP-associated factor 1D, Transcription initiation factor SL1/TIF-IB subunit D.
What are the subcellular locations of this protein?
Nucleus.
Protein: PP330_ARATH
Sequence: MSPFSETSVLLLPMVEKCINLLQTYGVSSITKLRQIHAFSIRHGVSISDAELGKHLIFYLVSLPSPPPMSYAHKVFSKIEKPINVFIWNTLIRGYAEIGNSISAFSLYREMRVSGLVEPDTHTYPFLIKAVTTMADVRLGETIHSVVIRSGFGSLIYVQNSLLHLYANCGDVASAYKVFDKMPEKDLVAWNSVINGFAENGKPEEALALYTEMNSKGIKPDGFTIVSLLSACAKIGALTLGKRVHVYMIKVGLTRNLHSSNVLLDLYARCGRVEEAKTLFDEMVDKNSVSWTSLIVGLAVNGFGKEAIELFKYMESTEGLLPCEITFVGILYACSHCGMVKEGFEYFRRMREEYKIEPRIEHFGCMVDLLARAGQVKKAYEYIKSMPMQPNVVIWRTLLGACTVHGDSDLAEFARIQILQLEPNHSGDYVLLSNMYASEQRWSDVQKIRKQMLRDGVKKVPGHSLVEVGNRVHEFLMGDKSHPQSDAIYAKLKEMTGRLRSEGYVPQISNVYVDVEEEEKENAVVYHSEKIAIAFMLISTPERSPITVVKNLRVCADCHLAIKLVSKVYNREIVVRDRSRFHHFKNGSCSCQDYW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At4g21065.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
Protein: RL29_RHIEC
Sequence: MKASDVRALTADQLKEELAKLKKEQFNLRFQKATGQLEKSSRINEVRKDIARVKTIARQKAAEVKA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: TRPC_PETMO
Sequence: MYLEKIVETKREEVAKLKEKKISLKDSFQKGKLTLIAEIKKASPSKGIISTNFDPQRQLELYIKGGADAISILTDEKYFQGSTNILKELRPKTNLPILRKDFIIDPIQIYQSLFLGANVILLIASILTKKEISNFLKISKDIGLEAIVEVHNHQELTKVLDTETEILGINNRDLSDFSLSLRNTEKLLEELEKLGKRRDFYVISESGIKEKSDIDYLRSLEVDGVLIGEALMKENDPVLKIGELFPEKRSNLQ
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: RECA_NEIMF
Sequence: MSDDKSKALAAALAQIEKSFGKGAIMKMDGSQQEENLEVISTGSLGLDLALGVGGLPRGRIVEIFGPESSGKTTLCLEAVAQCQKNGGVCAFVDAEHAFDPVYARKLGVKVEELYLSQPDTGEQALEICDTLVRSGGIDMVVVDSVAALVPKAEIEGDMGDSHVGLQARLMSQALRKLTGHIKKTNTLVVFINQIRMKIGVMFGSPETTTGGNALKFYSSVRLDIRRTGSIKKGEEVLGNETRVKVIKNKVAPPFRQAEFDILYGEGISWEGELIDIGVKNDIINKSGAWYSYNGAKIGQGKDNVRVWLKENPEIADEIDAKIRALNGIEMHITEGTQDETDGERPEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_CUPTR
Sequence: MPLNIEDKKAVVAEVSAQVAKAQTIVVAEYRGIAVGDLTKLRAAARQQGVYLRVLKNTLARRAVEGTPFAGLAEQMTGPLIYGISEDAVASAKVLNDFAKTNDKLVLRAGSYDGKVLDAAAVKALASIPSRDELIAQLLGVMQAPVSGFARLLAALAAKKAEGAAPAEAEAAAEA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: DUT_MUHVS
Sequence: MIKPNIPAPVRPNLPLSSPDSVLPQAMKDPFNIFDDDEPSEDTSSSEQSSRPPPREMMISSSCALREQTNSSFLNRFFPEDDESSENGAALAEINQLLRDGPEAPPREPTPKEARRPEKMQKIFFQTYGNDFKVEAHGDRLLAQNQRVVRLFERGRILGLGVKMNIPMGYCAVTNCFHPPGCVCVMDMAGYGPSDIRAQIVNISSGPLELPPNMLQIHIHMLPMLLPEPWQTINLMAPHQGDTYFDLRLRRPLSLPPRASKNLKFEAGHLCEEDARRCLVIPCRHLATKRVLLDPTVWRPNSLAVLRVLNASDEHVDLEAGMAMAKIIFTTPGITPFKPSLTSVMMSFDVPRSDLKLVKGGRRDYYRAEERMRSGRDSSNEG
What is the function of this protein?
Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: PLSX_STUS1
Sequence: MSAPVIAIDAMGGDFGPHCIVPASLSCLAENPSLHLVLVGQSSLLEQLVAKHPGVDRARLKIVDAPEMVTMDERPAQALRGKPRSSMRVALEQVRDGGAQACVSAGNTGALMALARQVLKTLPGIDRPAMVTALPTRGAPCLLLDLGANVDCPAEQLYQFAVMGAVAAESLGRQQPRVALLNVGTEEIKGNQQVKLAAALLQQAAGLNYRGFIEGDGLYRGEADVVVCDGFVGNILLKSSEGLAGMLVAKVEALFRRSIAARIVGAVALPLLRRLRAELNPAQYNGASFLGLQGIVVKSHGSAGADGFKAAIRRAAQDVEHDLPAQLRDRLGQFFRVDGSSGGTDDVTARDGWPSN
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
Protein: ARGA_PSEU2
Sequence: MPEYVNWLRHASPYINAHRDCTFVVMLPGDGVAHPNFGNIVHDLVLLHSLGVRLVLVHGSRPQIESRLAQRGITPRYHRDLRITDTETLECVIDAVGQLRISIEARLSMDMAASPMQGSRLRVTSGNVVTARPIGVLEGVDYQHTGEVRRVDRKGINRLLDERHIVLLSPLGYSPTGEIFNLACEDVATRAAIDLAADKLLLFGAETGLLDEQGRLVRELRPQQVPAHLQRLGANYQAELLDAAAEACRGGVARSHIVSYAENGALLTELFTRDGGGTLVAQEQFELVREAAIEDVGGLMDLITPLEEQGILVRRSREVLEREITQFSVVEREGLIIACAALYPIADSESGELACLAVNPEYRHGGRGDELLERIENRARALGIKTLFVLTTRTAHWFRERGFEPSSVDRLPSARASLYNYQRNSKIFEKAI
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_XANC5
Sequence: MTNLLWQKPGVAVDAKIQSFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLQELGGLSEQLDLLAADFRSGAFVLDAQYEDCHSAIEARLTERLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVATLSAEIAKVALDRAQAEAGLPVPGYTHIQRAVVSSAGMWWAGWAEAFIDNAVRADDTVRLVDSNPLGTAAGYGVNLPLDRAHTTAELGFARLLVSPIYAQLSRGKYELAALEALGSATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAARTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLPALLANLEWRPDKLRAAIDSGMYATDVAVEAAVAGVPFREAYKAAAQAAETAGQGRTPEGSLAARVSPGAAADLQLDVLQARWQALRA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NGFV5_TROCA
Sequence: MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSVANIIVDPKLFQKRRFQSPRVLFSIQPPPLSRDEQSVEFLDNEDTLNRNIRTKRETHPVYNRGEHSVCDSVSVWVTNKTKATDIKGNMVTVMVDINLNNEVYKQYFFETKCRNPNPVPSGCRGTDSRHWNSYCTTTQTFVRALTMEGNQASWRFIRIDTACVCVIIRKTDNF
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor 5, v-NGF-5, vNGF-5.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYK_METPP
Sequence: MTTTPPNAATPGTDDNQLIAERREKLAALRAQAQATGRAAFPNDFKPGDHAVDLHRLHEGKSAEELEALAIPARIAGRMMLKRVMGKACFATLQDGSGRIQLYITSDAVGPEALAAFKHWDLGDILGAEGTLFKTRTGELSLKVGTIRLLTKSLRPLPDKFHGMADQELKYRQREVDLIMDEASRERFRARSKAVSSIRQFMVEHGFLEVETPMLHPIPGGANAKPFVTHHNALDQQMFLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSVRHNPEFTMMEFYAAYWTHHDLMDFTEQILRHAARKAVGTAQLAYGGQAVDLESPFARLSVRDSLIAHAGLSAAEAADTTVLRAKLEAHGEKAPAHWSLAELQFGLFEAAVEEKLWQPTFIVDYPVEVSPLARASDADPTITERFELFITGREFGNGFSELNDPEDQAARFAAQASNKDAGDEEAMYFDTDYIRALEHGLPPTGGCGIGIDRLMMLLTDSPNIRDVILFPALRREG
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_RHOPB
Sequence: MELKVTTLEGKEAGSVQLSDEIFGLDPRVDIIQRCVNWQLAKRQAGTHKAKGRAEVWRTGKKMYKQKGTGGARHGSQRVPQFRGGGRAFGPVVRSHAFDLPKKVRALALKHALSAKAKDGGLIVIESATLEAAKTKALVGHFSGLGLTSALIIDGAELNNGFAVAARNIPNIDVLPIQGINVYDILRRQKLVLTKAAVDALEARFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: DER_ACIB5
Sequence: MKPVIALIGRPNVGKSTLFNQITKSRDALVADFAGLTRDRKYGDATYQNKSFIVVDTGGIGESECGIDNYMAEQSKTAINEADIIIFVVDARAGLLASDEQIARELRTLGKKIYLVANKVDGVHAEAALVEFYKLGMGEPLQVAASHGRGVQQMLEDVLQDIPEDENPEEHDKDTGLRLAIIGRPNVGKSTLVNRLLGEDRVVAFDQPGTTRDSIYIPFEREGRKYTLIDTAGVRRKGKVDEMIEKFSIVKTLQAMKDAHVVVVVVDAREGIVEQDLHLIGYALEAGRAMVIAINKWDNMSEYDRKQCKLDVERRFDFIPWARIHLISALHGTGVGELYPSIHRAYESANLKVSPAKLTQILNDATDQHQPPTVQGRRIKMRYAHMGGQNPPTIVIHGNKVDKTPADYRRYLENVFRKVYKLEGTPVKIEFKTSENPFEGRKSQVDERTAARRRRYIQKFKKAEKKFKR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RL29_SHEB8
Sequence: MKASELREKSVEELNAELLGLLREQFNLRMQHATGQLTQTNQLKLVRRNIARVKTIITSKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: YOBV_BACSU
Sequence: MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINRAGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQKIKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSASGETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLDTLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQWLIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YobV.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAN2_ORYSJ
Sequence: MALPNQGTVDYPSFKLVIVGDGGTGKTTFVKRHLTGEFEKKYEPTIGVEVHPLDFTTNCGKIRFYCWDTAGQEKFGGLRDGYYIHGQCAIIMFDVTSRLTYKNVPTWHRDLCRVCENIPIVLCGNKVDVKNRQVKAKQVTFHRKKNLQYYEISAKSNYNFEKPFLYLARKLAGDPNLHFVEAVALKPPEVPIDLAMQQQHEAELAAAAAQPLPDDDDDLIE
What is the function of this protein?
GTP-binding protein involved in nucleocytoplasmic transport.  Required for the import of protein into the nucleus and also for RNA export.  Involved in chromatin condensation and control of cell cycle (By similarity).
What are the official names of this protein?
GTP-binding nuclear protein Ran-2, OsRan2, Ras-related nuclear protein 2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NROR_CLOAB
Sequence: MKSTKILILGAGPAGFSAAKAALGKCDDITMINSEKYLPYYRPRLNEIIAKNKSIDDILIKKNDWYEKNNIKVITSEFATSIDPNNKLVTLKSGEKIKYEKLIIASGSIANKIKVPHADEIFSLYSYDDALKIKDECKNKGKAFIIGGGILGIELAQAIIDSGTPASIGIILEYPLERQLDRDGGLFLKDKLDRLGIKIYTNSNFEEMGDLIRSSCVITAVGVKPNLDFIKDTEIASKRGILVNDHMETSIKDIYACGDVAEFYGKNPGLINIANKQGEVAGLNACGEDASYSEIIPSPILKVSGISIISCGDIENNKPSKVFRSTQEDKYIVCMLKENKIDAAAVIGDVSLGTKLKKAIDSSKSFDNISSLDAILNNL
What is the function of this protein?
Catalyzes the NADH-dependent reduction of rubredoxin (Rd).  NADPH is a very poor electron donor compared to NADH.  Functions as an intermediate component in the electron transfer chain: NADH->NROR->Rd->FprA1/2.  Also functions as an intermediate component in the electron transfer chains from NADH to revRbr and Dfx.  Therefore, is a key electron carrier in an efficient multienzyme complex that can scavenge O(2) and reactive oxygen species (ROS), and thus plays an important role in the oxidative stress defense system in C. acetobutylicum, an obligate anaerobic bacterium.
What are the official names of this protein?
NADH-rubredoxin oxidoreductase, NROR, NADH:rubredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
Protein: SDC2B_XENLA
Sequence: MRNVWLIVPFALLAAFSGETWAQADRDLYIDSTESSGNYPVDDDDYSSGSGSGIPAHDDDEDNVVLTTVQTLISSPSSEMPYVDTTTLKTQTKMAPETKEPGEVESTNTVLVHENKNIIQTATHTENLFHRTEVLAAVIAGGGIGFLFAVFLILLLVYRMRKKDEGSYDLGERKPSSAVYQKAPTKEFYA
What is the function of this protein?
Cell surface proteoglycan.
What are the official names of this protein?
Syndecan-2-B, SYND2-B, Xsyn-2.
What is the protein family that this protein belongs to?
Belongs to the syndecan proteoglycan family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CRVP_LEIMD
Sequence: MIAFILLSLAAVLQQSFGTVDFDSESPRRPEKQREIVNMHNSLRRSVSPTASNMLKMEWYPEAASNAERWAYNCITGHSSNPSRVIDGIQCGENIYMSPVPITWTEIIQIWYDENKNFVYGVGANPPGSMIGHYTQIVWYKSYRIGCAAVYCPSTYYSYFYVCQYCPTGNFNGLYATPYKSGPPCGDCPSACVKGLCTNPCTVENKFTNCNTLV
What is the function of this protein?
Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction.  May target voltage-gated calcium channels on smooth muscle (By similarity).
What are the official names of this protein?
Cysteine-rich venom protein LEI1, CRVP, Cysteine-rich secretory protein LEI1, CRISP-LEI1.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECU_STRSV
Sequence: MVNYPHKLKAKSSINRPVPGIVNFANRGMSFEKMINESNSYYLSRGLAVIHKKPTPIQIVKVDYPHRSRAKIVEAYFRQASTTDYSGVYKGHYIDFEAKETRQKKSMPMKNFHSHQIEHMEAVLEQKGICFVLLHFSSLRETYLLPASYLIEFYKIDKGGKSMPLTYIQEHGYPIEMQQLPSIPYLEIIEQKLLGGIINE
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INO1_NICPA
Sequence: MFIENFKVESPNVKYTESEIHSVYDYQTTELVHDEKNGTYQWTVKPKTVKYEFKTDVHVPKLGVMLVGWGGNNGSTLTGGVIANREGISWATKDKVQQANYFGSLTQASTIRVGSFNGEEIYAPFKSLLPMVNPDDVVFGGWDISDMNLADAMARAKVFDIDLQKQLRPYMESMVPLPGIYDPDFIAANQGSRANNVIKGTKKEQIDQIIKDIREFKEKNKVDKVVVLWTANTERYSNVVVGLNDTMENLFASVDRNEAEISPSTLYAIACILENVPFINGSPQNTFVPGLIDLAIKKNTLIGGDDFKSGQTKMKSVLVDFLVGAGIKPTSIVSYNHLGNNDGMNLSAPQTFRSKEISKSNVVDDMVSSNAILYEPGEHPDHVVVIKYVPYVGDSKRAMDEYTSEIFMGGKNTIVLHNTCEDSLLAAPIILDLVLLAELSTRIQLKAEGEGKFHSFHPVATILSYLTKAPLVPPGTPVVNALSKQRAMLENILRACVGLAPENNMILEYK
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner.
What are the official names of this protein?
Inositol-3-phosphate synthase, MIP synthase, Myo-inositol 1-phosphate synthase, IPS, MI-1-P synthase.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_BRUAB
Sequence: MRVYYDRDADVNLIKSKKVVIVGYGSQGRAHALNLKDSGAANVRVALREGSATVQKAQADGFEVMNVADAAKWADLMMMATPDELQADIYRDHIHNNLRDGAAIAFAHGLNVHCGLIEPKKTVDVVMIAPKGPGHTVRGEYQKGGGVPCLIAIHQDASGNAHDLALSYASGVGGGRSGVIETTFKEECETDLFGEQAVLCGGVVELIRTGFEVLVEAGYAPEMAYFECLNEMKLIVDLIYEGGIANMNYSISNTAEWGEYVTGPRIITAETKAEMKRVLKDIQTGKFTSDWMQEWKAGAARFKGIRRLNDAHQIEEVGGKLRAMMPWIEKNKLVDKARN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ATG4D_XENLA
Sequence: MNSVSPLATQYGSPKGSQQMENRSTQSGGHEQRKMGHQDATLDGEADEVDKLKSKLLSAWNNVKYGWSVKMKTTFSRSAPVYLLGERYFFRLDDEIERFQKDFVSRVWLTYRRDFPALEGTALTTDCGWGCMIRSGQMLLAQGLLLHLLSREWTWSEALYRHFVEMEPIRSSSPPSMPLSSLATGHSAGDYQPHTQCSGAPHGDQVHRNIMRWFSDHPGSPFGLHQLVTLGSIFGKKAGDWYGPSIVAHIIKKAIETSSEVPELSVYVSQDCTVYKADIEQLFAGDVPHAETSRGAGKAVIILVPVRLGGETFNPVYKHCLKEFLRMPSCLGIIGGKPKHSLYFIGYQDNYLLYLDPHYCQPYIDTSKNDFPLESFHCNSPRKISITRMDPSCTFAFYAKNSEDFGKLCDHLMKVLHSPRAEEKYPIFSISEGQAQEYAEGPQSSSHPPVCRKKGPLVKRPSSDEFEFL
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (By similarity).  The protease activity is required for proteolytic activation of ATG8 family proteins to reveal a C-terminal glycine (By similarity).  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity).  In addition to the protease activity, also mediates delipidation of ATG8 family proteins.  Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (By similarity).  Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (By similarity).
What are the official names of this protein?
Cysteine protease ATG4D, Autophagy-related protein 4 homolog D, Autophagin-4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3178_HALH5
Sequence: MKVSYHGHSVVKIETEGKTIVIDPFITGNGLTDLSVDDLKVDVILLTHGHNDHVGDTLQLAKQNDALVIAPFELATYLSWKGVKVHEMHIGGAHQFEFGHVKLTQAFHGSSYTEENQTIVYTGMPSGILFTAEGKTIFHAGDTALFSDMKLIGERNTIDVAFLPIGDNFTMGPEDAAVAAEWLQAKTVVPIHYNTFPVIEQDPVAFAESLSGKKGRALAVGEAIEL
What are the official names of this protein?
UPF0173 metal-dependent hydrolase BH3178.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: YLZJ_BACSU
Sequence: MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEVIQIMSTNPMHFLHPDISPGQKLKLNV
What are the official names of this protein?
Uncharacterized protein YlzJ.
Protein: UVRC_WOLSU
Sequence: MQSETLLETLQNLPDQSGVYHYFDSRSKLLYVGKAKSLKKRVKSYFQFTPTLAPSPKLSPRIHKMISEAAFIRYIVVENEHDALILENSLIKQLKPKYNILLRDDKTYPYIYFDENESFPRLEITRKILPHKGVRYFGPYTTGARELLESLYELLPLVQKKGCLKAQKACLFYQIHRCLAPCESKISKERYGEIFKEALGLLQNHSKLISRLKERMEKLAENLRFEEAGELRDRIEKIKRIEAFSGIDLARLEDLDILAIATSGKHSMLTRLFMREGKVVSSTSTPLKAQEGLDEEEAYRRAILHYYDSFMPLPPKQILLPLELESKRELEAHLEGLFGRKIPLHHPKQGSKKALIDLALKNAEELLRLEGEKEEIPLLESLQELLGLESLPRRIEAFDTSHLRGEACVGAMVVYEEGFCKESYRRYALEGRDEYSQMREMLGRRAEAFDRESPPDLWLLDGGLGQIRLAQEIIESLGANVEIIAIAKEKIDAKAHRAKGAAKDILRTPTEEIRLLPSDKRLQLLQKIRDEVHRFAITYHRQQKLKKDRQIDLLEIKGIKKGKLKRLLDFFGSFEAIREASFEELCKVVSEGEARAILEASF
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MELD_BACSU
Sequence: MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGTLITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYALLLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALASPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPLLMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQGIFMAFVILIISFCALAYFKRKETEMS
What is the function of this protein?
Part of the ABC transporter complex MelEDC-MsmX involved in melibiose, raffinose and stachyose import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Melibiose/raffinose/stachyose import permease protein MelD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.