PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_SHEAM
Sequence: MIEADRLIQPQDLGQEDVIDRAMRPKLLDEYTGQDDTRAQLKVFIEAAKKRGEALDHMLIYGPPGLGKTTLANIVANEMGVNIKSTSGPVLEKAGDLAALLTNLEEGDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGSLTSPLRARFGIPLRLEFYNVRDLSSIVARSAKVMDVPMDEGGAEEIARRSRGTPRIANRLLRRVRDFAEVKHDGAISRAVAQSALDLLDVDSEGFDYMDRKLLLAIIDKFMGGPVGLDNLAAAIGEERETIEDVLEPFLIQQGFVQRTPRGRIATARAYSHFDLIKPD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LPXA_BURPS
Sequence: MSRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYKDEPTRLVIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIGHDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGGDGDAAVKSLVDFVESSQRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_SHEB9
Sequence: MKSHIQSLLEQTLESFKQQGIVPADFEARIQVDRTKDKSHGDLATNLAMMLTKVAGKNPRELAQLIIDTLPASAYVAKVEIAGPGFINFFINDSALADQLQNAVNDEHLGIKLPTPQTVVVDYSSPNLAKEMHVGHLRSTIIGDSVVRALEFLGHKVIRQNHVGDWGTQFGMLLAYMEELRAKNGEKAQLELSDLENFYRAAKLRFDESAEFATRARQLVVELQSGDEYCNKLWREFNDISLSHCHEVYARLGVSLTRADVHGESAYNADLEQVVKDLDAQGLLTESNGAKVVFQEAFRNKEGEPLPVIIQKADGGYLYATSDLAAMRYRSNVLKADRVLYFVDLRQALHFQQVFSLAKLAKFVREDMSLEHLGFGTMNGEDGRPFKTRSGGVVKLVDLLEEANVRALELVRSKNPDMDEVTLTEIARVVGISAVKYADLSKNRTSDYIFSFEQMLSFEGNTAPYLLYAYTRVAGIFKRVTDLDLSQAKIVLEHEKEKDLGNKLAQFGEILSRVVDKGQPHVLCAYLYELAGAFSSFYEACPVLAADNDAQKNSRLLLAQLTARTLQKGLNLLGIETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLUL1_CANLF
Sequence: MKPSLLVFTVYLLWLKDCHCAPTWKDKTDMHGNLKGFSEAGDIDVDEEVKKALIGMKQMKIMMERREEEHTNLMKTLKKCKEEKQEALKLMNEVQEHLEEEESLCQVSLTDSWDECKSCLESNCMRFHTTCQPSWSSMKNTVEQFFRNIYQYLFPFDEDNEKDLPVGEKFIEEDAQVAQIENVFNQLTVDVRFLFNRSLNVFKQMQQEFDQTFQSYFMSDTDLMQPNFLPALSKEPRKKADPVQSWDIPSFFQLFYNFSLSIYHSISTTITKTLNAIEDLPKQDNDSNHGSLSSKTLPVQHRGPYGEFGQNLSECFQFHARCQKCQDYLWEDCPDVPELHTKVDEALELVNISHQQYAQVLQMTQHHLEDTTYLMEKMREEFGWVADLANQAPGAENIFDSTKMVPNIHEGNFSKQDETMIDLSILSSPNFTLKIPLEESAETSNFISYMLEKAVQHFKKHFKTW
What are the official names of this protein?
Clusterin-like protein 1, Retinal-specific clusterin-like protein.
What is the protein family that this protein belongs to?
Belongs to the clusterin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CCMD_HAEIN
Sequence: MFFQTWSDFFNMGGYGFYVWLSYAVSLVAVIALIVQSVKQRKTVLQNVLREKQREERLQQANKGNTL
What is the function of this protein?
Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
What are the official names of this protein?
Heme exporter protein D, Cytochrome c-type biogenesis protein CcmD.
What is the protein family that this protein belongs to?
Belongs to the CcmD/CycX/HelD family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PLSX_STAEQ
Sequence: MVKIAVDMMGGDDAPGIVLDAVKKAVEDFKDLEIILFGDESQYNLSHERIEFRHCTEKIEMEDEPVRAIKRKKDSSMVKMAEAVKSGEADGCVSAGNTGALMSAGLFIVGRIKGVARPALVVTLPTTDGKGFVFLDVGANADAKAEHLLQYAQLGNIYAQKIRGIQNPSVSLLNIGTEAAKGNSLTKKAYDLFEKNQSFNFTGNIEAKTLMDGNVDVVVTDGYTGNMVLKNLEGTAKSIGKMLKETIMSSFKNKLAGAVLKKDLDTFAKKMDYSEYGGSVLLGLDGTVVKAHGSSNAKAFYSAIRQAKIAGEENIVQIMKDTVGE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: CP139_MYCTO
Sequence: MRYPLGEALLALYRWRGPLINAGVGGHGYTYLLGAEANRFVFANADAFSWSQTFESLVPVDGPTALIVSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNIDTVIDGWQPGQRLDIYQELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTRRPPQVMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSEEGTTLSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAADDLSALTYLNGVVHETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPEIWPEPTEFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVARAMLQLPAQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ
What are the official names of this protein?
Putative cytochrome P450 139.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: ATP6_BUCAP
Sequence: MSLEKISNPQKYISHHLNHLQIDLCNFKFVEPGKIVSHFWVLNIDSIIFSLVLGCFFLSIFYTVAKKITTGVPNGLQASIELIFDFIRSNVKSMYQGKNPLIAPLSLTVFVWVFLMNLMDLIPIDFFPFISERFFHFPAMRIVPSADINITLSMSLGVFILILFYSVKMKGLIGFCKELTLQPFNHPVFFIFNFLLELVSLLSKPISLGLRLFGNMYSGEMIFILIAGLLPWWSQFFLNVPWAIFHILIISLQAFIFMVLTIVYLSMASQSH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS21_ECO55
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: PSMA2_STAA3
Sequence: MGIIAGIIKFIKGLIEKFTGK
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.  Stimulates the secretion of the chemotactic factor interleukin-8 (IL-8).  The ensuing activation process triggers an inflammatory response in the host, thus contributing greatly to virulence.  Also possesses hemolytic activity, which may contribute to the development of disease.
What are the official names of this protein?
Phenol-soluble modulin alpha 2 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: AMPA_SALA4
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMRELGMNAYLAVGHGSQNESLMSVIEYKGNPSEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMSNHNPLAHELIGASEQAGDRAWRLPLGDEFQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLSQFLLNRAGFNGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFB_KLEPN
Sequence: MTSCSSFSGGKACRPADDSALTPLVADKAAAHPCYSRHGHHRFARMHLPVAPACNLQCNYCNRKFDCSNESRPGVSSTLLTPEQAVVKVRQVAQAIPQLSVVGIAGPGDPLANIARTFRTLELIREQLPDLKLCLSTNGLVLPDAVDRLLDVGVDHVTVTINTLDAEIAAQIYAWLWLDGERYSGREAGEILIARQLEGVRRLTAKGVLVKINSVLIPGINDSGMAGVSRALRASGAFIHNIMPLIARPEHGTVFGLNGQPEPDAETLAATRSRCGEVMPQMTHCHQCRADAIGMLGEDRSQQFTQLPAPESLPAWLPILHQRAQLHASIATRGESEADDACLVAVASSRGDVIDCHFGHADRFYIYSLSAAGMVLVNERFTPKYCQGRDDCEPQDNAARFAAILELLADVKAVFCVRIGHTPWQQLEQEGIEPCVDGAWRPVSEVLPAWWQQRRGSWPAALPHKGVA
What is the function of this protein?
Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms.  NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.
What are the official names of this protein?
FeMo cofactor biosynthesis protein NifB, Nitrogenase cofactor maturase NifB, Radical SAM assemblase NifB.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. NifB family.
Protein: PSBM_LACSA
Sequence: MEVNILAFIATALFILVPTAFLLIIYVKTVSQNN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: GCH1_BRUSI
Sequence: MDARILQDNDDTSLPVNQASVTRIHKKPGKPEAEAAVRTLLLWAGEDPDREGLLETPKRVAKAYQELFGGYSESPEEVLGTTFEEVAGYDDMVLVKDISFFSHCEHHMVPIIGKAHVAYLPEGRVVGLSKIARVVDIFARRLQTQESITAQIADSIQRILKPRGVAVMIEAEHMCMAMRSIRKQGSSTITTTFTGDFKEKADQQVRFMTLIRT
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: ERF77_ARATH
Sequence: MTTEKENVTTAVAVKDGGEKSKEVSDKGVKKRKNVTKALAVNDGGEKSKEVRYRGVRRRPWGRYAAEIRDPVKKKRVWLGSFNTGEEAARAYDSAAIRFRGSKATTNFPLIGYYGISSATPVNNNLSETVSDGNANLPLVGDDGNALASPVNNTLSETARDGTLPSDCHDMLSPGVAEAVAGFFLDLPEVIALKEELDRVCPDQFESIDMGLTIGPQTAVEEPETSSAVDCKLRMEPDLDLNASP
What is the function of this protein?
Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.  Transcription factor that binds to the GCC-box pathogenesis-related promoter element.  Acts as a transcriptional inhibitor and may regulate other AtERFs (By similarity).
What are the official names of this protein?
Ethylene-responsive transcription factor 10, AtERF10, Ethylene-responsive element-binding factor 10, EREBP-10.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y766_PSEAB
Sequence: MSYVIDRRLNGKNKSTVNRQRFLRRYREHIKKAVEEAVSRRSITDMEHGEQISIPGRDIDEPVLHHGRGGRQTVVHPGNKEFTAGEHIARPSGGGGGRGGGKASNSGEGMDDFVFQITQEEFLDFMFEDLELPNLVKRHITGTDTFKTVRAGISNDGNPSRINIVRTLRSAHARRIALSGGSRAKLRAALKELERIKREEPDNLGDIQELELEIAKLRARIDRVPFLDTFDLKYNLLVKQPNPTSKAVMFCLMDVSGSMTQATKDIAKRFFILLYLFLKRNYEKIEVVFIRHHTSAREVDEEEFFYSRETGGTIVSSALKMMQEIMAERYPTHEWNIYAAQASDGDNWNDDSPVCRDILLKQIMPFVQYYTYVEITPREHQALWFEYERVREAFEDSFAQQQIVSASDIYPVFRELFQRRLVA
What are the official names of this protein?
UPF0229 protein PA14_07660.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: AP1B_DICDI
Sequence: MSDSKYFQTTKKGEIHELKEELLSQREDKKKEAVKKVIAAMTVGKDVSMLFTHVLNCMQTHNLELKKLVYLYVMNYAKNHPDRAILAVNTFQKDASDPNPLIRALAVRTMGCIRVDNITEHLCEPLRHALKDQDPYVRKTAAVCVAKLYDVNPELVENQGFLNILNDLLGDSNPMVVANAVASLTEIDEVSKKEVFRIHSGNLNKLLAALNECTEWGQVFILNSLCKYTPRDSQEAENVCERVAPRLQHANSAVVLSAVKVLMKYMNSIGNNDVIRLFCKKMAPPLVTLLSKEPEIQFLGLRNINLIVQKRPEILQYEMKVFFCKYNDPIYVKMEKLEIMIMLANEKNIEEVLLEFKEYATEIDVEFVRKAVRAIGRCAIKIDRASERCIQVLLDLIQTKVNYVVQEAIIVIKDIFRKYPNKYEGIIATLCANLESLDEPEAKASMIWIIGEYAERIDNAHELLNSFLEGFKDENSQVQLQLLTSIVKLFLKRPKDAQQMVQTVLNLSTQESDNPDLRDRGFVYWRLLSTDFEAAKAVVLSEKPLITDTTSHLDESLLNELILNISTLASVYHKPPETFVTKLKGLNKRGLRNKEEEDEEEPDYVDDDNMNNQQGGQQQQGGYQQQQQQQQQGGYQQQQPQQQQPKSGNLIDLDLSDLGGALPNNNNNNYGNNNNNNMYSPQPQQFNGNSNDLSFLGGGGGGGEVQAPVNKVVVFGGDRSQAIQISGAFTRFQGRINLELNLLNTSQQGMSKFKIQFYQNSFGISPADQILSCGAIEVGQSTDVTIPISCNGQISNPLNPVIDMAMMVLPSQERFYFKMNFPLLCLLTETGRLDRESYLSMWKSIPESNERSVEIQVRLPHVDVDSILRRLNSKNIFEIVRKKAPNQEISFLSCKTESSVYILIELAFNISTNTCRCSSKTTSPDIMALFEHNLNLLINNQI
What is the function of this protein?
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes.  The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.  Also involved in early steps of phagocytosis and macropinocytosis.
What are the official names of this protein?
AP-1 complex subunit beta, Adaptor protein complex AP-1 subunit beta, Adaptor-related protein complex 1 subunit beta, Beta-1-adaptin, Beta-adaptin 1, Clathrin assembly protein complex 1 beta large chain.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle membrane.
Protein: CASP3_MACFA
Sequence: MENTENSVDSKSIKSLEPKIIHGSKSVDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMASRSGTDVDAANLRETFINLKYGVRNKNDLTREEIVELMRNVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPLDLKKITSFFRGDCCRSLTGKPKLFIIQACRGTELDCGIEADSGVEDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYFYH
What is the function of this protein?
Involved in the activation cascade of caspases responsible for apoptosis execution.  At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond.  Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain.  Cleaves and activates caspase-6, -7 and -9.  Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).  Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity).  Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress.  Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction.  Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity).  Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
What are the official names of this protein?
Caspase-3, CASP-3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAD_RAT
Sequence: MCAARRRELALIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEESSQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHAPQYAFAGSNVDLPLLDWLNKYTFPTEKRFQSTDVAEEVYTRVVRRTLKNGTTTACYFGTIHTDSSLILAEITDKFGQRAFVGKVCMDLNNTVPEYKETTEESVKETERFVSEMLQKNYSRVKPIVTPRFSLSCTETLMSELGNIAKTHDLYIQSHISENREEIEAVKSLYPGYKNYTDVYDKNNLLTNKTVMAHGCYLSEEELNVFSERGASIAHCPNSNLSLSSGLLNVLDVLKHKVKIGLGTDVAGGYSYSMLDAIRRAVMVSNVLLINKVNEKSLTLKEVFRLATLGGSQALGLDREIGNFEVGKDFDALLINPRASDSPIDLFCGDFVGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
What is the function of this protein?
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
What are the official names of this protein?
Guanine deaminase, Guanase, Guanine aminase, Guanine aminohydrolase, GAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
Protein: DPHB_METTH
Sequence: MLYIIGLGLYDENDISIKGLRAIEDCDEVYAEFYTAMLQGSSLSAIERRIGRSVKVLGRGEIEEERIPIERALELDVALLVAGDPLVATTHTELLIDAHRRGIETRVIHSSSIISAAPGLAGLQAYKFGRIITIPFTSDNYFPTSPYTNIGENLKAGSHSLVLLDIEAHRNRYMTATEGLRYLLKASEKLDDGTISGETLAVVIARAGSEKPLVRADKIATLVEEDFGDPLHCLVVPAGLHFIEADYLVEIAGAPRAVVERMIL
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: HLY3_BACSU
Sequence: MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSFTIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLGFTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSLLFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS
What are the official names of this protein?
Hemolysin-3 homolog, Hemolysin III homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0073 (Hly-III) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL9_WOLPM
Sequence: MLIILKENIRTLGKLGEVVKVKPGYARNFLFPQRKAVKATKENLTKLEEQRLLLEEENIKRLNVAKELALSLHDKFVVLIKQASEDGKIFGSVTTREIAKILLQEGHVIDHRSLSFGGVSIKNLGEYQVNVELHSEVVVPITIYVVKSETDANELRQVKLQNQKSEQQEAEQDANKEATDGDDS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y4106_ANAD2
Sequence: MPQDAPAGLAPGFLVAAPALADPNFNGSLVLMAEHHAQGALGFVVNRPGPITVADVLGGLDAGLRERAEGAGRADDPVLVGGPVQPERLWILFRPGPAAPEEGAVALGAGLALGGSRELLEALVRARDPGPYLLLLGYAGWAPLQVEREVGEGAWVPLPLQGDLVFDVPMEKRWETAVRRLGLDPAGFLVGGGGAEA
What are the official names of this protein?
UPF0301 protein A2cp1_4106.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: RUVB_CYTH3
Sequence: MREDYLKSDDEQFTSGEKEIERALRPLSFDDFAGQDKILENLKIFVGAAKQRGEPLDHVLLHGPPGLGKTTLSNIISNELNSNIKITSGPVLEKPGDLAGLLTNLQTNDVLFIDEIHRLNSVVEEYLYSAMEDYKIDIMLDSGANARSIQIGLNPFTLIGATTRAGLLTSPLRARFGINARLEYYDAKLLTRIVQRSSDLLNTPILETAAFEIARRSRGTPRIANNLLRRTRDFAQIKGDGTITLEIARIALQALNVDHNGLDDMDNRILTTIIDKFKGGPVGLSTIATAVSEEAETIEEVYEPFLIQEGYLKRTSRGREVTPLAYKHLQRTPPAQSGTLFE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: UB2V2_BOVIN
Sequence: MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN
What is the function of this protein?
Has no ubiquitin ligase activity on its own.  The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.  This type of poly-ubiquitination does not lead to protein degradation by the proteasome.  Mediates transcriptional activation of target genes.  Plays a role in the control of progress through the cell cycle and differentiation.  Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 variant 2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: ACOD_CYPCA
Sequence: MPDREIKSPIWHPEPGTVEDVFDHTYKEKEGPKPPTVIVWRNVILMSLLHLGALYGLFLFPSARALTWIWFFGCLLFSALGITAGAHRLWSHRSYKASLPLQIFLALGNSMAFQNDIYEWSRDHRVHHKYSETDADPHNAVRGFFFSHVGWLLVRKHPDVIEKGRKLELSDLKADKVVMFQRRFYKPSVLLMCFFVPTFVPWYVWGESLWVAYFVPALLRYALVLNATWLVNSAAHMWGNRPYDSSINPRENRFVTFSAIGEGFHNYHHTFPFDYATSEFGCKLNLTTCCFIDLMCFLGLAREPKRVSREAVLARAQRTGDGSHWSG
What is the function of this protein?
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.  Has high specificity and catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.  Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides.
What are the official names of this protein?
Acyl-CoA desaturase, Delta(9)-desaturase, Delta-9 desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.