PharMolix/UniProtQA huggingface dataset:
Protein: BRE1B_HUMAN
Sequence: MSGPGNKRAAGDGGSGPPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGITPGAQGPSSRGREPEARPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYIS
What is the function of this protein?
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1).  H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively).  It thereby plays a central role in histone code and gene regulation.  The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory.  Required for transcriptional activation of Hox genes.
What are the official names of this protein?
E3 ubiquitin-protein ligase BRE1B, BRE1-B, 95 kDa retinoblastoma-associated protein, RBP95, RING finger protein 40, RING-type E3 ubiquitin transferase BRE1B.
What is the protein family that this protein belongs to?
Belongs to the BRE1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: D3_CAMPS
Sequence: MDIFIVKDNKYPKVDNDDNEVFILLGNHNDFIRSKLTKLKEHVFFSEYIVTPDTYGSLCVELNGSSFQHGGRYIEVEEFIDTGRQVRWCSTSNHISEDIPEDIHTDKFVIYDIYTFDSFKNKRLVFVQVPTSLGDDSYLTNPLLSPYYRNSVARQMVNDMIFNQDSFLKYLLEHLIRSHYRVSKHITIVRYKDTEELNLTRICYNRDKFKAFAFAWFNGVLENEKVLDTYKKVSDLI
What is the function of this protein?
Late protein which is part of a large complex required for early virion morphogenesis.  This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions (By similarity).
What are the official names of this protein?
27 kDa core protein.
What is the protein family that this protein belongs to?
Belongs to the chordopoxvirinae D3 family.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: PYRD_NITSB
Sequence: MDYESIKKILFHFDPETAHHIAESAFELASFFPFILNRLQEKFLVKDPMLSQELFGKTFCNPLGIAAGFDKNATMTKTLHALGFGYVEIGTVTPKPQSGNPKPRLFRYIKQEAIQNAMGFNNDGAEVIKARLQRITPASFPIGVNIGKNKTTPDEQALQDYRFLIKTFHSLSDYLVINISSPNTPGLRDLQNESFIKELFSMAKELTNTPVLLKIAPDMSEDQAVSLCSTAVDAGAAGVIATNTSIDYSLLRGAKDFGGVSGKVIKEKSFAIFKAVAKELFGKTVLISVGGIDSAEEAYRRIRHGATLLQIYTSFIYGGPGLVKSINEGLIEYLKKDGFTHISEAIGIDIR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DCA11_MOUSE
Sequence: MGSRNSSSAGSGSLEPSEGLSRRGTGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQGRGAANLQLIQALSDSEEEHDSAWDGRLGDRYNPPVDATPDTRELEYNEIKTQVGLATGRLGLRRTALQQSFPQMLHQRERGLCHRGSFSLGEQSRVMSHFLPNDLSFTDTYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRLAATQQNWDYRWQQVPKIAWKKLKLPGDSSLMTYRGHGVLHTLIRCRFSPAHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESDMNRVCSSGPTPVPCPSVAFSSPQ
What is the function of this protein?
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
What are the official names of this protein?
DDB1- and CUL4-associated factor 11, WD repeat-containing protein 23.
Protein: SYP_LISW6
Sequence: MRQTMTFIPTLKEVPADAEVKSHQLLLRAGFIRQTASGIYSYLPLATLMLRKIEAIIREELEAIGAAELLLPALQPAELWQESGRWNDYGPELMRLKDRASRDFALGPTHEEVITALLRDEVKSYKRLPLTLYQIQTKFRDEKRPRFGLLRGREFIMKDAYSFHATSESLDEVYKLMHQAYSNIFTRCGLEFRSVIADSGSIGGNESKEFMALSEIGEDTIAYSDASDYAANTEMAPVLYMEKKSHELEKELEKVATANQKFIADIVEFLEVPIEKTIKSMLYQVDEEVIMVLVRGDHEVNDIKIKNALDATNVELVDPAVPVEILGANFGSLGPIGVPENIRVFADNAVKDIANAVVGANEDGYHYVNVNPNRDFEVTSYFDLRMIQAGDLSPDGQGVIKFAEGIEVGHIFKLGTKYSEAMNATILDENGRAQPIIMGCYGIGVSRILSAIAEQSNDENGLVWDKQISPFDLHLIPVNMKSEEQVAFAESLYDSLQKAGFSVLIDDRAERAGVKFADADLIGLPIRITVGKKAAEGIVEVKIRKTGEMIEVRQDELLNTLPILFGDK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURT_YERPS
Sequence: MLTIGTALRPGATRVMLLGAGELGKEVAIECQRLGLEVIAVDRYADAPAMHVAHRSHVINMLDGAALKQLVAQEKPHYIVPEIEAIATDMLVELEKMGQHVVPCAEATRLTMNREGIRRLAAETLQLPTSSYRFADTDSAFFQAVRDIGYPCIVKPVMSSSGKGQSLIRSEEHLQAAWEYAQQGGRAGSGRVIIEGLVHFDFEITLLTIRAVDGIHFCAPIGHRQEDGDYRESWQPQAMSDIALQRAKEISAQVVTALGGFGLFGVELFVCGDDVIFSEVSPRPHDTGMVTLISQNMSEFALHVRAFLGLPIGTIRQYGAAASAVILPELTSQNITYRGLETALIGDTQIRLFGKPEIAGQRRLGVALAVADNIETAIEVAKKAAGNIEVSGE
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: YIDD_ECOBW
Sequence: MAPPLSPGSRVLIALIRVYQRLISPLLGPHCRFTPTCSSYGIEALRRFGVIKGSWLTVKRVLKCHPLHPGGDDPVPPGPFDTREH
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: OFUT1_ARATH
Sequence: MRRLGHHRLHGKTGGVGTKGMVAKLSIGVIVLLICTLSLLFSANIGSNREPTRPSKINVEELWESAKSGGWRPSSAPRSDWPPPTKETNGYLRVRCNGGLNQQRSAICNAVLAARIMNATLVLPELDANSFWHDDSGFQGIYDVEHFIETLKYDVKIVGKIPDVHKNGKTKKIKAFQIRPPRDAPIEWYLTTALKAMREHSAIYLTPFSHRLAEEIDNPEYQRLRCRVNYHALRFKPHIMKLSESIVDKLRSQGHFMSIHLRFEMDMLAFAGCFDIFNPEEQKILRKYRKENFADKRLIYNERRAIGKCPLTPEEVGLILRAMRFDNSTRIYLAAGELFGGEQFMKPFRTLFPRLDNHSSVDPSEELSATSQGLIGSAVDYMVCLLSDIFMPTYDGPSNFANNLLGHRLYYGFRTTIRPDRKALAPIFIAREKGKRAGFEEAVRRVMLKTNFGGPHKRVSPESFYTNSWPECFCQMNPKKSSDKCPPNNVIEILDSRLESIRDPDSTSQTNSTVTGLER
What are the official names of this protein?
O-fucosyltransferase 1, O-FucT-1, O-fucosyltransferase family protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase GT106 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: OSM1_DROME
Sequence: MQLKYLRTLLEGQEQIQRIAGLAWSPNQQRLAIATADRHILLYDDAGERRDKFSTKPANPANGKNSYVIRGLAFSPDSTKLAVGQSDSIVYVYKLGESWNDKKVICNKFPQASAVTALIWLTSGSIIAGLEDGKVRALHSKSNKSQSLYGGDSICISLAANTKGTGFLSGHNDGTIIRYFMTDEATEPLGRVVQHPVPPFALAWPQGGFCAGGCDQRIVFYDSMGRQLRTFDHSRTEGEREFTVAACSPNGQAVAFGSFDRIRIFAWSPRQGAWSESATKEVACLYTLSSLLWRRDGARLALGSVSGAVLLFESVLRRTVWQDKFELIFVAPSQLLVRSLTEPSQALTIESQLGLEIDDVRIMGRDNYLVARTEESLILCDLTRNLSSEVPWTASGHHERFYFENPTVCLIFNVGELSLVEYGENSILGSVRTEFVNPHVISVRLNERGNAKENKKLAFLLDAKTICVVDLISRMTSGQISHETKIDWLELSETAHKLLFRDKKLRLILVDNYTGKKQTLLSNISFVQWVPQSDVVVAQSNSNLAIWYNIDLPEHVTMQSVRGEAIEVLRENGRTVVRSQDGPSEHNYQLDEGLVEFGTAVNDSDFGRAVHFLESLGDKPAAKAMWHNLALIALEDGNLRVAQRCYAALGNVSKAYYLAGMIQQADEFEESSGSPGILCPEVRAKLALLGSDLRTAERIYLEQGDIESALKMYQQLGMWDEAVALAERRGYNRIAELKQQHMDYLLSSEQQEKAGQVLEEQGDLQQAMSLYMKANKPARAARLALKTPHILQDEQVMLQVTEGLVRSELYELAGDIAHRLSRPEAALALYRKGGAYARALEIGRVVAPQEVTALEEEWGDWLVSRKQLDASINHYIEAGATQKALEAAVGAKQWRKAVQIAKVLDEPELIQRYAVDLAKHLAFAGDLDGAEDMLVRANLHKDAIELLNRHGKWERAYLIGEKHLKAEQVRELFVQLAGTLEEQGKFRDAEKVLIAVNEPDLAIAMYKRRELYDSMIRLVERYHKDLLDSTHLHLARQLESRGKLKNAEMHFVASGDWKSAVHMYCSSGRWEDGYRVAKLKGTEGASQQVAYMWAKSMPTEGAVRLLSKLGLLDTAVGFACDSGQFEFAMELCKFAGKPTDEVHLKIAMSLEDEGKFEAAEAEFLKANKPREAILMYQHAGDWQAALNVAENHLPDAVGEVLIGQASAALETSNYKDYEALLLRAHRPDLIIEHYKQESLYEDALRIAEEHYPSALNDLRRLQAQLQRGQAQAQAGEDAASISRSYLQKAAEFAKKEQFRKAAECLMQIDSSNAEDASTLERALLRAAEICNQFLEGQDAQELAQSLGPRLLAIKQIGPAAQLYLAADMPKQAVDVFIKTEQWSKARRLAKEIDPDLQLLAYVEQQQKASLKHEGNIEQLADIDIVSALDLLAEHGEWQRCLEKAKGLNPALLQKYVAVYAAQLIREGNCTTALGLYLSYGAPPIEAHFNIYTRIALDCLALREEQTERGTTWRQLRDFLFRLLQSLKATPAQSQTKFAASMEQFLLIAHYYATRAACKEVQALQPVALRLSLALLRHTDLLPVDKGFYEAGMDLRQAGREAEAFVMLNHYLDVCEAIEEGSGQLVDHSDLASTDFPSSVPLPEDIHLKNDPSLHEEVREWVLAVSMDQQVDQQLPTDDRGLYESSLGPNDLPCMLSGFPVRGRQPVTFQGSSNQVNRDVWSKFSVALKMSPGSGIADIISFTEKWQGAANYVMH
What is the function of this protein?
Required for the maintenance and formation of cilia.
What are the official names of this protein?
Intraflagellar transport protein 172 homolog, Osmotic avoidance abnormal protein 1 homolog, Outer segment 2.
What is the protein family that this protein belongs to?
Belongs to the IFT172 family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: BAMA_SALA4
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGNTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTLSDIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAKIQQINIVGNHAFSTEELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYITVNITEGDQYKLSGVQVSGNLAGHSAEIEKLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSQPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDSVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYSVGINGTKNDYQTYSELSVTNPYFTVDGVSLGGRIFYNDFEADDADLSDYTNKSYGTDVTLGFPINEYNTLRAGLGYVHNKLSNMQPQIAMDRYLESMGDPDASDFAADDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVSLDTATYVPIDNDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYKNGARTSGGDNDEYEDCTQESGCKSDDAVGGNAMAVASLEFITPTPFISEKYANSVRTSFFWDMGTVWDTNWDPSSAPSDVPDYSDPGNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: Y2915_MYCTU
Sequence: MKRVDTIRPRSRAVRLHVRGLGLPDETAIQLWIVDGRISTEPVAGADTVFDGGWILPGLVDAHCHVGLGKHGNVELDEAIAQAETERDVGALLLRDCGSPTDTRGLDDHEDLPRIIRAGRHLARPKRYIAGFAVELEDESQLPAAVAEQARRGDGWVKLVGDWIDRQIGDLAPLWSDDVLKAAIDTAHAQGARVTAHVFSEDALPGLINAGIDCIEHGTGLTDDTIALMLEHGTALVPTLINLENFPGIADAAGRYPTYAAHMRDLYARGYGRVAAAREAGVPVYAGTDAGSTIEHGRIADEVAALQRIGMTAHEALGAACWDARRWLGRPGLDDRASADLLCYAQDPRQGPGVLQHPDLVILRGRTFGP
What are the official names of this protein?
Uncharacterized protein Rv2915c.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily.
Protein: GL88_ORYSJ
Sequence: MASPSFCLLAALLALVSWQAIASDPSPLQDFCVADKHSPVLVNGFACLDPKYVTADHFFKAAMLDTPRKTNKVGSNVTLINVMQIPGLNTLGISIARIDYAPLGENPPHTHPRATEILTVLEGTLYVGFVTSNPNNTLFSKVLNKGDVFVFPEGLIHFQFNPNPHQPAVAIAALSSQNPGAITIANAVFGSKPPISDKVLAKAFQVEKGTIDWLQAQFWENNHY
What is the function of this protein?
Plays role in broad-spectrum disease resistance.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Germin-like protein 8-8.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: YIDC_VIBVU
Sequence: MDSQRTLLVLLLALVSFLLFQQWQVAKNPAPQAVEQAQTSSTLPAPSFADELDPAPAQQASAKLITVTTDVLTLSIDTVGGDVVAADLNQYSAELNSANAFELLRDTQGHQFIAQSGLVGPQGIDLSSNNRPSYQVSADSFTLADDQNELRIPMTYQANGLEYTKTFILKRGSYAIDVEFDVINKSGNNATLGMYAHLRQNLMDAGGSITMPTYRGGAYSTEDTRYKKYSFEDMQDRNLSLTLTNGQGWAAMIQHYFAAAWIPRNEPGANLYTRVIGNMGDIGVRMPNKTIADGDSAHFTATLWAGPKLQDQMAEVAPNLDLVVDYGWLWFIAKPLHWLLSVIQSFVGNWGVAIICLTFIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGGCLPLILQMPIFIALYWALMESVELRHSPFILWIHDLSAQDPYFILPLLMGGSMFLIQKMSPTTVTDPMQQKIMTFMPVMFTFFFLWFPSGLVLYWLVSNIVTLIQQSLIYKALEKKGLHTK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RAPA_ECOL6
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDLINYLASPDETEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: RBM22_DANRE
Sequence: MATSLGSNTYNRQNWEDSDFPILCQTCLGENPYIRMTKEKFGKECKICARPFTVFRWCPGVRMRFKKTEVCQTCSKMKNVCQTCLLDLEYGLPIQVRDTGLSVKDEVPRSDVNKEYYTQNMEREIANSDGTRPVGLLGKAPSSSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVANKLLMRASTMPRLDVPDDKSITTLYIGGLGENVTDSELRNHFYQFGEIRTITIVQRQQCAFIQFATRQAAETAAEKSFNKLIINGRRLNVKWGRSQAARGKGEKDGVTESGIRLEPVPGLPGALPPPPVSDEDASTNYFNLAPTPSPAVMNLGLPPPPGVTMPPPPGFGPPMFHTMDPMAPPVPPPMALRPPGQVHYPSQDPQRMGAHASRHGGP
What is the function of this protein?
Required for pre-mRNA splicing as component of the activated spliceosome.  Involved in the first step of pre-mRNA splicing.  Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity).  Required for normal early embryogenesis (PubMed:20013661).
What are the official names of this protein?
Pre-mRNA-splicing factor RBM22, RNA-binding motif protein 22.
What is the protein family that this protein belongs to?
Belongs to the SLT11 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nearly exclusively nuclear. May be shuttling between the nucleus and the cytosol.
Protein: CO5A2_MOUSE
Sequence: MMANWVGARPLLILSVLLGYCVSIKAQEQENDEYDEEIACTQHGQMYLNRDIWKPSPCQICVCDNGAILCDKIECPEVLNCANPITPTGECCPVCPQTGGGDTSFGRGRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGDRGPKGRPGPRGPQGIDGEPGVPGQPGAPGPPGHPSHPGPDGMSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGGVGPAGPPGEPGEPGPMGPIGSRGPEGPPGKPGEDGEPGRNGNTGEVGFSGSPGARGFPGAPGLPGLKGHRGHKGLEGPKGEIGAPGAKGEAGPTGPMGAMGPLGPRGMPGERGRLGPQGAPGKRGAHGMPGKPGPMGPLGIPGSSGFPGNPGMKGEAGPTGARGPEGPQGQRGETGPPGPAGSQGLPGAVGTDGTPGAKGPTGSAGTSGPPGLAGPPGSPGPQGSTGPQGIRGQSGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRGDPGTVGPPGPMGERGAPGNRGFPGSDGLPGPKGAQGERGPVGSSGPKGGQGDPGRPGEPGLPGARGLTGNPGVQGPEGKLGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDLGKPGEAGNAGVPGQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKAGDQGVPGEPGAVGPLGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGNPGPTGTIGDTGPPGLQGMPGERGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPHGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPAGEPGKEGPPGLRGDPGSHGRVGDRGPAGPPGSPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGERGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGEPGSRGPVGPPGRAGKRGLPGPQGPRGDKGDNGDRGDRGQKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDENMPDPLPEFTEDQAAPDDTNKTDPGIHVTLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHPTKQSGEYWIDPNQGSAEDAIKVYCNMETGETCISANPASVPRKTWWASKSPDNKPVWYGLDMNRGSQFTYGDYQSPNTAITQMTFLRLLSKEASQNLTYICRNTVGYMDDQAKNLKKAVVLKGSNDLEIKGEGNIRFRYTVLQDTCSKRNGNVGKTIFEYRTQNVARLPIIDVGPVDIGNADQEFGLDIGPVCFM
What is the function of this protein?
Type V collagen is a member of group I collagen (fibrillar forming collagen).  It is a minor connective tissue component of nearly ubiquitous distribution.  Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.  Type V collagen is a key determinant in the assembly of tissue-specific matrices.
What are the official names of this protein?
Collagen alpha-2(V) chain.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TM234_PONAB
Sequence: MAASLGQVLALVLVAALWGGTQPLLKRASAALQRVREPTWVRQLLQEMQTLFLNTEYLMPFLLNQCGSLLYYLTLASTDLTLAVPICNSLAIIFTLIVGKALGEDIGGKRAVAGMVLTVIGISLCITSSWQVPWTAELQLHGKGQLQTLSQKCKREASGAQSERFG
What are the official names of this protein?
Transmembrane protein 234.
What is the protein family that this protein belongs to?
Belongs to the TMEM234 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RASF3_HUMAN
Sequence: MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKETHSYLSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPPQTSPNSGKLSPSSNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGEWEAFSLPELQNFLRILDKEEDEQLQNLKRRYTAYRQKLEEALREVWKPD
What are the official names of this protein?
Ras association domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Localized to microtubules in vascular endothelial cells.
Protein: YO114_YEAST
Sequence: MTTLMGKFKLTGRSPLFVLQPMLHCKKQQFVEEAVRLISNKKIGKKSDFVQARNWVGALNVTGLPLNQFILRYDRASGPGGQNVNKVNSKCTLTLSGLSNCAWIPQEVRNILSSGRFRYYAKGSDSIVIQSDETRSRETNKLKCFEKLVQEIRQTCQFPNDTTAETSKKWNKIKEKANKERLLDKKVHSDKKKNRSKIKFNY
What are the official names of this protein?
Putative uncharacterized protein YOL114C.
Protein: PAT_CROS8
Sequence: MNRLPNSASALACTAHALNLIEKRTLTHEEMKALNREVHDYFEQHVNPGFLEYRKSVTAGGDYGAVEWQAGGLNTLVDTQGQEFLDCLGGFGIFNVGHRNPVVVSAVENQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAAIKLAKAYQSPRGKFTFVAASGAFHGKSLGALSATAKAAFRKPFMPLLPGFRHVPFGNIDALRELLGECKKTGDDVAAVILEPIQGEGGVILPPSGYLPAVRKLCDEYGALLIFDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGATVATEEVFSVLFDNPFLHTTTFGGNPLACAAALATIHVLLEENLPAQAEQKGDMLLDGFRQLAREYPHLVQEARGRGMLMAIEFVDNETGYRFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCEQVLTAARRALETLSTAQSTTAVATES
What is the function of this protein?
Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline.  This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal.  Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Putrescine aminotransferase, PAT, PATase, Cadaverine transaminase, Diamine transaminase, Putrescine transaminase, Putrescine--2-oxoglutaric acid transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.
Protein: RL3_ACIB3
Sequence: MAIGLVGRKCGMTRIFTDAGVSVPVTVIEVDPNRITQIKTLETDGYQAVQVTTGERRESRVTNAQKGHFAKAGVAAGRLVKEFRVTEAELEGREVGGTIGVDLFTVGQIVDVTGQSKGKGFQGGVKRWNFRTQDATHGNSVSHRVLGSTGQNQTPGRVFKGKKMAGHLGDERVTVQGLEIVSVDTERSVLVVKGAIPGATGGDVIVRPTIKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: MURG_CAMFF
Sequence: MIAITGGGTGGHLAIAKALAIELKNRGENVIFIGSNSGQDRMWFEHSDIFKFKYFFPSRGVVNKKGIHKLFALLNIIKLAFKCRCIFTEHNISSVISVGGYSSAPASFGAVIFRKKLFIHEQNAIKGKLNSILKPFCKKFFSSYGTDTYDYPIDIKFFNTARVRNELKTILFLGGSQGASFINSLALNLALNLKNHNINIIHQCGAKELETTRSKYNEMGVEAVVFDFSNEIEVYMQKSDLCISRAGASTLWELCANALPTIFIPYPYAASNHQFYNAKFLLDSNLAKIYEQNGLDKNILFTDIMNLDINSISMGLRNIVSPNGAKIIIDKILKQ
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.