PharMolix/UniProtQA huggingface dataset:
Protein: YOQI_BACSU
Sequence: MIKSIILPEENTKITVGKPINDESNTKVIAIYDYREEPEEAFWVHLSNGNDLFVDNHEVIVEYE
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YoqI.
Protein: SOX9_HUMAN
Sequence: MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAPQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP
What is the function of this protein?
Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782).  Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233).  Also binds to some promoter regions (By similarity).  Plays a central role in successive steps of chondrocyte differentiation (By similarity).  Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity).  Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity).  Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity).  Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity).  Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity).  Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity).  Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity).  In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity).  Controls epithelial branching during kidney development (By similarity).
What are the official names of this protein?
Transcription factor SOX-9.
What are the subcellular locations of this protein?
Nucleus.
Protein: VATE_HALLT
Sequence: MSLDTVVEDVRDEARARAEDIREAAESEADEIVAEAEADAERIREERLAEVDRQIDQEREQTLSSAKLEAKQERLGARRDVLEDVYDDVEAAIEGLDGDRRRELTETLLDATLAEFDDDEDVAVYTHTEDVDLVEELVEDRNAVVDGEIDCLGGVVAESDTSRVRVNNTFDSILESVWDDELKNISERLFDQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type proton ATPase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: LYOX_MOUSE
Sequence: MRFAWAVLLLGPLQLCPLLRCAPQTPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDPSATARRPDGDAASQPRTPILLLRDNRTASTRARTPSPSGVAAGRPRPAARHWFQAGFSPSGARDGASRRAANRTASPQPPQLSNLRPPSHIDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGSRNRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
What is the function of this protein?
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin.  Regulator of Ras expression.  May play a role in tumor suppression.  Plays a role in the aortic wall architecture (PubMed:27432961).
What are the official names of this protein?
Protein-lysine 6-oxidase, Lysyl oxidase, Ras excision protein.
What is the protein family that this protein belongs to?
Belongs to the lysyl oxidase family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space.
Protein: TDXH1_PICTO
Sequence: MEGKMPLIGEKFPEMEVVTNLGNIKLPDDFKGKWFVLFSHPGDFTPVCTTEFFSFAKHHDDFKKLNTELIGLSVDSKISHIEWINWIKQNLKIDIKFPIIADPMGHVATKLGMIQAQSATQTVRAVFIVDDRSTIRAILYYPMETGRNISEILRLIKSLQMVDKYKIVTPANWPNNEIIGDNVLNPPPATQNDIEERTKKYKGYAWWLTYQDANKADVDEAKEITGE
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Peroxiredoxin 1, Thioredoxin-dependent peroxiredoxin 1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF24_ARATH
Sequence: MASSKFVLFAILALSLLLSGTEARKTVWPSSELDPKCCSNQPEFGICDSKEDDERCAQMCLDGCPTNKGGGCQPITEAPGAVCSCYCA
What are the official names of this protein?
Defensin-like protein 24.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXA_YERP3
Sequence: MIDKTAFIHPSSIVEEGAIIGAGVYIGPFCIVGSQVEIGAGTELKSHVVVNGITKIGCDNQIYQFASIGEANQDLKYAGEPTRVEVGDRNRIRESVTIHRGTTQGGGVTKVGCDNLLMVNTHVAHDCVIGNRCILANNAALGGHVEIDDYAIIGGMTAIHQFCVIGAHVMVGGCSGITQDVPPFVIAQGNHATPFGINIEGLKRRGFDKESLHAIRSAYKLLYRSGRTLDEVKPEIAELAEQYPVVKAFNDFFARSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRB_BURCM
Sequence: MSHDTDDKTYPYQKDDAELRRRLTPMQYEVTQHAATERAFTGEYTDTEDAGIYKCVVCSTPLFESGAKFHSGCGWPSYFKPLNGEVIDEKIDRTHGMVRVEVRCNHCGAHLGHVFEDGPRDKTGLRYCINSAALNFESRPENE
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: SYP1_BACAH
Sequence: MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKELEKVATPDQKAIEEVSAFLNIEADKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEVKELLNCEVGSLGPIGVNGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase 1, Prolyl-tRNA synthetase 1, ProRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_ACTP7
Sequence: MNNWTEALGEEKQQPYFQHILQQVHQERMNGVTVFPPQKEVFSAFALTEFKDVKVVILGQDPYHGPNQAHGLAFSVKPPVAPPPSLVNMYKELAQDVEGFQIPNHGYLVDWAKQGVLLLNTVLTVRQGQAHSHANFGWEIFTDKVIAQLNQHRENLVFLLWGSHAQKKGQFIDRSRHCVLTAPHPSPLSAYRGFFGCKHFSKTNRYLLSKGIAPINWQLRLEIDY
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_RHOPS
Sequence: MDQGQTLARLLDSYATDPRKRAVAAAVGAIAEASIEISELIGQGALAGITGAAHGASNADGDVQKDLDVRAEAAIVAALKNVPYAALASEEAEALLMGDPQAPISIAYDPLDGSSNIDTNMTVGTIFSIIPNEPGVAPFTAPGSCQLAAGFVVYGPQTSFVLTLGDGVDIFTLDRKDHVYRLIREKVKVAGDTAEYAINASNHRHWEQPVRDFVDECLAGADGPRAKNFNMRWIGSLVAEAYRILTRGGVFLYPADSRPGYGDGRLRLLYETHPMAFVMEQAGGAASTGRERVLDLSAAATSTHQRSPLIMGSSDKVNRIVELHLDPSAASRTAPLFGRRGLFRT
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_RALPJ
Sequence: MSQLTHFDSAGQAHMVDVGDKAVTHRVAVATGTIRMLPETFALVRDGNAKKGDVLGIARVAAIQGSKRTSDLIPLCHPLALTKVAVEFELNEAGHSVRCTVRAETRGQTGVEMEALTAVQVGLLTIYDMCKAVDRGMVIGDVRLMEKRGGKSGDWVAD
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: MATK_QUEPA
Sequence: MEEFQGYLELDRFQQHDFLYPLIFREYSYALAHGHGLNRYMLLENIGYDNKSSLLIVKRLITTMYQQNYLKISANDSKQNPFFGYNKNLHSKILSEGFAIIVEIPFYLRLISSLEGAEIVRFYNLRSIHSIFPFLEEKFPHLNYSADILIPYPAHLEILVQTLRYRVKDASYLHLLRFFLHEYSNCNSLIITNKSISIFSKSNPRFFLFLYNSYICEYESIFLFLRNQPSHLRLTSSGVLFERLCLYRKIEHFAEVFSNDFPVIPCFLKDPFMHYVRYQGKSILASKDTPLLMNKWKSYLVNLWQCHFDVWSHAASIRINQLSKHSLDFLSYFSSVRRNPAVVRNQMLENSFLLNNAPNKLDTMVPIIPLIGSLAKAKFCNAVGHPISKLTRADLSDFEIINRFLHICRNLSHYYSGSSKKKNMYRIKYILRLSCVKTLARKHKSTARAFLKRVDLEFFQEFFTEEGGFISLIFPRASFALRRLYSGRVWYLDIIFINGLSNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYGA_DICT6
Sequence: MLFQEIIFKLNEFWHKQGCIIQQPYDIEVGAGTMNPATFFRVLGPEPWYVAYVEPSRRPTDGRYGENPNRLQHYYQYQVILKPSPANVQEIYIESLEYLGIDIEKHDIRFVEDNWESPTLGAWGIGWEVWLDGMEITQFTYFQQCGGFDLFPISAEITYGLERIAMYIQGIDDFKDIKWQDGITYGDIHLQSEVENCIYNFELADVERLRLLFNEYEKEAERLLNEGLTFPGYDYVLKCSHTFNLLDARGAISVVQRSQYISRIRRLAAKAAENYLKSREALGFPLLNKAWRKEEAQIG
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPQV_MYCBO
Sequence: MRPSRYAPLLCAMVLALAWLSAVAGCSRGGSSKAGRSSSVAGTLPAGVVGVSPAGVTTRVDAPAESTEEEYYQACHAARLWMDAQPGSGESLIEPYLAVVQASPSGVAGSWHIRWAALTPARQAAVIVAARAAANAECG
What are the official names of this protein?
Putative lipoprotein LpqV.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GLPE_PSEAE
Sequence: MSDTFQRIAPEQVRQLRENGAQVVDIRDPQSFAVGHISGSRHIDNHSVADFIAAADLDAPLVVVCYHGNSSQSAAAYFIQQGFSDVYSLDGGFELWRSVYPADTSSGEAE
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPR2_ARATH
Sequence: MEPSRRRMTRDMLLLIVTMAWLVTGDEGGIKQEERLFNLGKLEMFVDKLPHIPTLHGYHFVNGFLKPKSLHIGMFFKKWKFHRDLPATPVFAYGTSKRSATVPGPTIEAVYGVDTYVTWRNHLPLHHILPWDPTISPAIPKHGGIPTVVHLHGGIHEPTSDGNADSWFTAGFKETGSKWTKKTTHYVNKQQPGNMWYHDHAAGLTRVNLLAGLLGSYILRHSSVESPLRLPTGREFDRPLVIFDRSFRKDGSIYMNATGNNPTIHPQWQPEYFGDAIIVNGKAWPRLTVRRRKYRFRITNASNARFFRFFFSNGLDFIVVGSDSAYLAKPVSTKSVLLAPSEIVDVLVDFSKSTSKTAILANNAPYPYPSGDPVTEENSKVMKFIINYKSEVDTSIIPKKLIEYPPAHVSTSTRTRYIAMFEYVSSIDEPTHLYINGLPYNAPVTETPKIGTSEVWEVINLTEDNHPLHIHLGLFKVLEQTALVKSEEFIECMTKRNDAVKCEISKYARGNKTAVTVHERGWKNVFKMMPGHVTKILVRFSYIHSNESYSFDATQEPGYVYHCHILDHEDNMMMRPFAMVL
What is the function of this protein?
Multicopper oxidase that may be involved in copper homeostasis and oxidative stress response, and that is necessary for root growth inhibition by low phosphate conditions.  Functions together with LPR1 and PDR2 in a common pathway that adjusts root meristem activity to phosphate availability.
What are the official names of this protein?
Multicopper oxidase LPR2, Protein LOW PHOSPHATE ROOT 2.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Associates with PDR2 at the ER membrane.
Protein: CEP63_DANRE
Sequence: MEEFLSTLRDHDASSVLSSCEPELQELMRQIDIMMGHKRHEWEAEVRAMELSLHNTQEELQSAKALLDKRNSEIRVLGKQLEELHTGKQELVVKYEEQLLHVKEELSKLKRSYEKLQRKHLKESRDGALSREEDRTELSRLNSKIEEFRQRSAEWEQQRLQYQRQVSLLEEQRKTLAEQFSLIQSQGVGRPQEQGQGELQRLRSQLQRAQDSLHAQELELERLRLLQDELGDSIKEQQVSCHAAAHRRGQVLSEEREELKATLDAQDQFVRSTGVQQQQLRREVNRLNQTLQAKEQVIRSLEECLSSPGSAPNLASLRQDLEKVTARLNSSQTCESHLKAEVMRLRDKLESMRKYKAEMSRREHEWKQMEEEHSRCTAENKRLRDELERAEQTRCGEQEGMRKEVFQLTSELHQRDITIATLTGSTSSIERQLRAEVERAERRASELKVTQVQLETLKLENQHLNDLLERVESQSPKRGDGELASLRDSYVSSLKSLEEENRQLRLEMTELRARMEASNQTWQDKYERALLQNQNKNHLYNEQNRADEDVQRRHQEELQAMETQMQERASHYEEQIQTLLTQLENLSRTSPYRPDGQTQESKTSVSPARSSASSASSSSSTRKAQRVATLLSAVANGEEAQASSSDSTGSPNTSVTTRFLEEETLRSQELLQRLDAHIQSMKLENSNTVCKYLGKTGNPQNDVFWQGTHSFCKMID
What is the function of this protein?
Required for normal spindle assembly.  Plays a key role in mother-centriole-dependent centriole duplication.  Plays a role in DNA damage response.  Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.
What are the official names of this protein?
Centrosomal protein of 63 kDa, Cep63.
What is the protein family that this protein belongs to?
Belongs to the CEP63 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: LIPA_AGRFC
Sequence: MVTILDRTSSDEKRIRHPEKAHRPDTEVMRKPEWIRVKAPTSKGYHETRELVRSHKLVTVCEEAGCPNIGECWEKKHATFMIMGEICTRACAFCNVATGKPNALDMDEPENVAKAVKQMGLSHVVITSVDRDDLADGGAEHFEKVIWAIRAASPTTTIEILTPDFLKKPGALERVVAAKPDVFNHNMETVPGNYLTVRPGARYFHSVRLLQRVKELDPTMFTKSGIMVGLGEERNEVLQLMDDLRSADVDFLTIGQYLQPTRKHHKVEAFVTPEEFKSYETVAYAKGFLMVSSSPLTRSSHHAGDDFERLRAAREKKLLAAAE
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METAS_SALTI
Sequence: MPIRVLDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDARESRNTPAEHLNNFYCNFDDICDQNFDGLIVTGAPLGLVEFNDVAYWPQIRQVLEWAKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAHTLAGEYFRDVEAGLNPEIPYNYFPKNDPQSIPRTTWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JZT1C_CHIGU
Sequence: MKTSILFVIFSLALVFALSPATEIEETDRACGQFWWKCGEGKPPCCANFACKIGLYLCIWSP
What is the function of this protein?
Moderately inhibits voltage-gated sodium channels and weakly inhibits voltage-gated potassium channel (PubMed:17150181, PubMed:17618665, PubMed:23246579, PubMed:26721415).  Inhibits the inactivation of rat Nav1. 2/SCN2A (IC(50)=870 nM), rat Nav1. 3/SCN3A (IC(50)=845 nM), rat Nav1. 4/SCN4A (IC(50)=339 nM), human Nav1. 5/SCN5A (IC(50)=335 nM) and human Nav1. 7/SCN9A sodium channels (IC(50)=348 nM) (PubMed:26721415).  The toxin delays the inactivation of sodium channels without affecting the activation and steady-state inactivation kinetics in the physiological range of voltages (PubMed:26721415).  Site-directed mutagenesis of the sodium channel indicates that the toxin interacts with site 3 located at the extracellular S3-S4 linker of domain IV (PubMed:26721415).  On potassium channels, it inhibits activation of channels with an IC(50) of 8. 05 uM through a voltage sensor-trapping mechanism (PubMed:23246579).  It increases muscle contraction in several assays (mouse phrenic nerve-diaphragm, toad heart, rat vas deferens) and is suggested to act both presynaptically and postsynaptically (PubMed:17618665).
What are the official names of this protein?
Delta-theraphotoxin-Cg1a 3, Delta-TRTX-Cg1a, Jingzhaotoxin-1.3, JZTX-1.3, Jingzhaotoxin-I.3, JZTX-I.3, Peptide F5-24.92.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 33 (Jztx-1) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL25_NITSB
Sequence: MLEGIVRESTGKKATKALRRDGYLIANIYGKDFPNIHAAFKKGDFIRTVRHKEKLAFPVKVGDKELEVVVQEYQKDPVTYDLLHVDLMVAQPGVVTYYMVPIKTVGTPIGLKNKGVLVTSKRRIKVKGAIENIPDSITLDVSNLDVGDAILIRDIELPEGVEHMTAPHVAVVGVVKAK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: PSBX_PROM9
Sequence: MFQISNLLLAADFSSEVANNSAVGMIGSFIAAALLIVIPATAFLIFVSQKDSLNRTSTGRR
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: NB1_MYCBO
Sequence: MTRDLAPALQALSPLLGSWAGRGAGKYPTIRPFEYLEEVVFAHVGKPFLTYTQQTRAVADGKPLHSETGYLRVCRPGCVELVLAHPSGITEIEVGTYSVTGDVIELELSTRADGSIGLAPTAKEVTALDRSYRIDGDELSYSLQMRAVGQPLQDHLAAVLHRQR
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase 1, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: CFM3A_ARATH
Sequence: MAMKPSLHFCPTTVTKKFVYSFQSSFCFRFLRYSSSISLGSCKGVTFSSRNDQIASRRFSFSRDCNNGVWLENWNRIQKRNQPKPPKVVVNYRKEGRFSGSEIVSGDDNRSRDGDGSTMEKIVEKLKKYGYMEEVQNKEIEQERRIEKGSVEDIFYVEEGKLPNTRGGFTEESLLGGENVIGSNGDVGFPWEKMSAKEKKELEAEWTAKKENRYSLAEMTLPESELRRLRNLTFRTASKMRIRGGGVTQVAVDAIKEKWKSAEIVRLKIEGASALNMRKMHEILEKKTGGLVIWRSGTSISLYRGVSYELPSGKWNKQRREETPPEAVIENHDETTTMVDKSDEKVHLPQLEQETTSVEKKDQTSPVVEYEDELDELLDDLGPRFMDWPGDNPLPVDADLLPGAIPDYEPPFRVLPYGVRSSLGPKEATALRRLARSIPPHFALGRSRQLQGLATAMVRLWEKSMLAKIAIKRGVQSTTSERMAEDLKKLTGGIMLSRNKDFLVFYRGKNFLSREVADALVEQERFVRTLQDEEEQARLRGSSALIVPSTEPANKLVSAGTLGETLDATGKWGKNLDDDDHSDEVKQEVEILRHENLVRKLERKLAFAERKLLKAERGLAKVEVCLKPAEQREDPESITDEERFMFRKLGLKMKAFLLLGRRGVFDGTVENMHLHWKYRELVKIIVKAKTFDGVKKVALALEAESGGILVSIDKVTKGYAIIVYRGQDYKRPTMLRPKNLLTKRKALARSIELQRREGLLKHISTMQAKAKQLRAEIEQMEKVTDKGDEELYNKLDMAYASSDEETDEEDDDDAFPETYAEGEDGEEGEILAGELSETEDKDLDSNESETGFGDDSVLFAEDLHTKSEDLPNKKVRLQHQS
What is the function of this protein?
Binds specific group II introns in chloroplasts and facilitates their splicing.  Acts on subgroup IIB introns.  The substrates of the subgroup IIB also require the CRM domain proteins CAF1 or CAF2, with a simultaneous binding of CFM3A and CAF1 or CAF2.  Required for seed development.  May influence the biogenesis of the mitochondrial small ribosomal subunit.
What are the official names of this protein?
CRM-domain containing factor CFM3A, chloroplastic/mitochondrial, Protein CRM FAMILY MEMBER 3A, AtCFM3a.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion.
Protein: PYRE_CRYNH
Sequence: MSSQALDSAKIAFIEAAIEHGVLLFGNFTLKSGRQSPYFFNAGLLYSSSLLSTTAQAYAKVLSSSRIPDFDVLFGPAYKGISLAAVSAVSLYQQTGKDIGYCYNRKEKKDHGEGGTMVGAPLKGRIVIIDDVLTSGKAIREAIDILKASPEAKLVGIVQLVDRQEKGQSGSGKSTVQEVEEEFGVPVEPIIGLDDIVKYLESSGKWEKELQEVRKYRAEYGVQRS
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ORN_MYCSS
Sequence: MRDELVWIDCEMTGLDLRSDLLIEIAVLVTDADLNILGDGLDVVIHAPDEALDAMIPVVTEMHTRSGLIEEVRASTVDLATAEEMVLDYIRGHVKQAKTAPLAGNSIATDRGFIARDMAKLDDYLHYRMIDVSSIKELCRRWYPRIYFGQPEKGLAHRALADIHESIRELKYYRQTAFVAPPGPSTSDIAAIAAELGPPGKDAADTDSAAGHTTG
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.