PharMolix/UniProtQA huggingface dataset:
Protein: AATNT_AQUAE
Sequence: MVCPKVVILSEGADLDSLSAAYGVLKLYPDAYLLKPKHLSKKAGEVFKKYRDKFRVIEDLPDCFELVLVDTHFLPEGLPRERIKRIIVYDHHPIGDVKEFEGKIEKVGAATTLVVEEIKEKGIDINPRDATLLAFGIYEDTGNFTYEGTTPRDALALAFLLEKGANLREIREVVMETYTPEQIEAVGKIVQSIEKVFINGRQISFATAVLERYQPDINTLLYEIKDLKESDAFFVIIEAEGKTYVFGRSQSEDVDVGEILSHFGGGGHREAGAVKLENVSAERIKELIKAFLKRKYVKLKVRDIMNTPPFVLEEHVSVKDALTELSERGIANAPVINREGKLVGIISKKALLKLVKLYPDEPIELFVNRDFYTLSPDAPVWEAEEILTKFGQKLIPVVEDGTVVGVVTRLDILQAVKEDLEKLKEKRRKIKVPENIEEIAREVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETYPRPGAYPKVEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKQGLKGKELGERIEELKREIMNKI
What is the function of this protein?
tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus.  Adds the terminal adenosine residue to tRNA (PubMed:11701927, PubMed:25914059).  Can incorporate CMP into tRNA ending with C74C75 (tRNACC), with very weak efficiency (PubMed:25914059).
What are the official names of this protein?
A-adding tRNA nucleotidyltransferase, A-adding TNT, A-adding enzyme.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Protein: ML4_VISAL
Sequence: YERLDLDVTSQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSGGGVEAARFVLVELTNEGGDSITAAIDVTNLYVVAYQAGSQSYFLSGPGTHLFTGTTRSSLPFNGSYPDLEQYAGHRKQIPLGIDQLIQSVTALRFPGNTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTEGVFNNPIRLAIPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMNVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATIWQIWGNGTIINPRSNLALAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFNDLCMESNGGSVWVETCVSQQNDRWALYGDGSIRPEQNQDQCLTSGRDSVAGINIVSCSGGSSGQRWVFTNEGAILNLKNGLAMDVANPGLGQIIIYPATGKPNQMWLPVP
What is the function of this protein?
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA.  The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity).  Inhibits growth of the human tumor cell line Molt4.
What are the official names of this protein?
Beta-galactoside-specific lectin 4, Beta-galactoside-specific lectin IV.
What is the protein family that this protein belongs to?
Belongs to the ribosome-inactivating protein family. Type 2 RIP subfamily.
Protein: HPPD_CAEEL
Sequence: MTTFDKGAKPDIGTFVAFDHVRFVVGNAKQAAYWYCANFGFEPFAYKGLETGSRITAQHAIRQDKIVFIFESALLPDNSELGNHLVQHGDGVKDVCFEVEDLDSIIAHAKAAGATIVHDITEESDADGSIRYATLRTYGETDHTLLERKNYRGAFLPGFKAHPMPATFFKTLPRVGLNFLDHCVGNQPDLQMDSAVQWYEKVLKFHRFWSVDDSMIHTEYSALRSIVVTNFEETIKMPINEPATSDKKAISQIQEYVDYYGGSGVQHIALNTSDIITAIEALRARGCEFLSIPSSYYDNLKERLAASSMVVKEDMDRLQKLHILVDFDENGYLLQIFSKPCQDRPTLFLEIIQRQNHEGFGAGNFKALFESIELEQTKRGNLFYDNVKDGNTK
What is the function of this protein?
Key enzyme in the degradation of tyrosine.
What are the official names of this protein?
4-hydroxyphenylpyruvate dioxygenase, 4-hydroxyphenylpyruvic acid oxidase, 4HPPD, HPD, HPPDase.
What is the protein family that this protein belongs to?
Belongs to the 4HPPD family.
Protein: IL10H_HCMVA
Sequence: MLSVMVSSSLVLIVFFLGASEEAKPATTTIKNTKPQCRPEDYATRLQDLRVTFHRVKPTLQREDDYSVWLDGTVVKGCWGCSVMDWLLRRYLEIVFPAGDHVYPGLKTELHSMRSTLESIYKDMRQCPLLGCGDKSVISRLSQEAERKSDNGTRKGLSELDTLFSRLEEYLHSRK
What is the function of this protein?
Functional viral IL-10 homolog.  Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites.  Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and biological activities.  IL-10 signaling pathway has several immunosuppressive activities that are exploited by the virus.  Inhibits TLR-induced type I interferon production in host plasmacytoid dendritic cells.
What are the official names of this protein?
Viral interleukin-10 homolog, cmvIL-10, vIL-10.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PLSC_YEAST
Sequence: MSVIGRFLYYLRSVLVVLALAGCGFYGVIASILCTLIGKQHLAQWITARCFYHVMKLMLGLDVKVVGEENLAKKPYIMIANHQSTLDIFMLGRIFPPGCTVTAKKSLKYVPFLGWFMALSGTYFLDRSKRQEAIDTLNKGLENVKKNKRALWVFPEGTRSYTSELTMLPFKKGAFHLAQQGKIPIVPVVVSNTSTLVSPKYGVFNRGCMIVRILKPISTENLTKDKIGEFAEKVRDQMVDTLKEIGYSPAINDTTLPPQAIEYAALQHDKKVNKKIKNEPVPSVSISNDVNTHNEGSSVKKMH
What is the function of this protein?
Acyltransferase that catalyzes the sn-2-specific, acyl-CoA-dependent acylation of lysophosphatidic acid (LPA) to phosphatidic acid (PA) in lipid particles (PubMed:9401016).  Together with ALE1, plays a central role in PA biosynthesis.  PA is the intermediate, from which all glycerophospholipids are synthesized (PubMed:17890783).  Can also acylate lysophosphoinositol (LPI) and lysophosphoserine (LPS) (PubMed:17675291).  The fatty acyl substrates include 18:1-acyl-CoA, 14:0-acyl-CoA, 12:0-acyl-CoA and 10:0-acyl-CoA (PubMed:20694142).
What are the official names of this protein?
1-acyl-sn-glycerol-3-phosphate acyltransferase, 1-AGP acyltransferase, 1-AGPAT, Lysophosphatidic acid acyltransferase, LPAAT, Sphingolipid compensation protein 1.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Lipid droplet.
Protein: PSBA1_SYNPW
Sequence: MTTTIQQRSGANGWQSFCEWVTSTNNRLYVGWFGVLMIPTLLAATTCFIVAFIAAPPVDIDGIREPVAGSLIYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVVFHFLIGIFCYMGREWELSYRLGMRPWICVAYSAPVAAASAVFLVYPFGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHMMGVAGVFGGSLFSAMHGSLVTSSLVRETTESESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGVSTMAFNLNGFNFNQSILDGQGRVLNTWADVLNRANLGMEVMHERNAHNFPLDLAAAESTPVALQAPAIG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1 1, PSII D1 protein 1, Photosystem II Q(B) protein 1.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: SUFS_SALEP
Sequence: MTFPVEKVRADFPILQREVNGLPLAYLDSAASAQKPNQVIDAESAFYRHGYAAVHRGIHTLSAQATESMENVRKQASRFINARSAEELVFVRGTTEGINLVANSWGTENIRAGDNIIISEMEHHANIVPWQMLCERKGAELRVIPLHPDGTLRLETLAALFDDRTRLLAITHVSNVLGTENPLPDMIALARQHGAKVLVDGAQAVMHHAVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEGGGSMISTVSLTQGTTWAKAPWRFEAGTPNTGGIIGLGAAIDYVTSLGLDKIGDYEQMLMRYALEQLAQVPDITLYGPAQRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAWYGVPAMCRASLAMYNTHEEVDRLVAGLTRIHRLLG
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo.
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_SHIDS
Sequence: MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKIKGFSGEDATPALEGADVVLISAGVARKPGMDRSDLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGVTTLDIIRSNTFVAELKGKQPGEVEVPVIGGHSGVTILPLLSQVLGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQGVVECAYVEGDGQYARFFSQPLLLGKSGVEERKSIGTLSAFEQNALEGMLDTLKKDIALGEEFVNK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: LIRA5_HUMAN
Sequence: MAPWSHPSAQLQPVGGDAVSPALMVLLCLGLSLGPRTHVQAGNLSKATLWAEPGSVISRGNSVTIRCQGTLEAQEYRLVKEGSPEPWDTQNPLEPKNKARFSIPSMTEHHAGRYRCYYYSPAGWSEPSDPLELVVTGFYNKPTLSALPSPVVTSGENVTLQCGSRLRFDRFILTEEGDHKLSWTLDSQLTPSGQFQALFPVGPVTPSHRWMLRCYGSRRHILQVWSEPSDLLEIPVSGAADNLSPSQNKSDSGTASHLQDYAVENLIRMGMAGLILVVLGILIFQDWHSQRSPQAAAGR
What is the function of this protein?
May play a role in triggering innate immune responses.  Does not seem to play a role for any class I MHC antigen recognition.
What are the official names of this protein?
Leukocyte immunoglobulin-like receptor subfamily A member 5, CD85 antigen-like family member F, Immunoglobulin-like transcript 11, ILT-11, Leukocyte immunoglobulin-like receptor 9, LIR-9.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Protein: AC4CH_ECOBW
Sequence: MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELKKVIADIYPGQTQFYVIEFKCL
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: AROQ_BACCQ
Sequence: MKKVLLVNGPNLNRLGVREVNVYGKGTLATLEADMKQEAETMGVELECFQSNHEGAIIDRIHEAEDIYEGIILNPGAFTHYSYAIRDAIASISIPVIEVHISNIHQRESFRHESVTAAVCAGQIVGFGFYGYKLALFALMEKLREA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: COXX2_BACCN
Sequence: MNHATSELHDESAVTDVPETTRVQDLLALVKMGIVNSNTLTVFTGFWLALHFNGLNALEHLDKMFFTIVGSALIMAGSCSLNNYIDRDIDHLMERTKNRPTVTGKYKPGFVLTLGVTLLLLGFVFLLLTTAMAALIGFIGAFTYVVLYSLWTKRAYTLNTVVGSVSGAVPPLIGWAAIHPSLDHPIAWMLFLIMFIWQIPHFLALAMKRVDEYRNAGIPMLPVVHGFDITKRQIMIWTVCLLPLPFYMSGLGITFMIIATLLNIGWIVLGFYGFRKKDDIKWSVQMFVYSLNYLTILFVSMIVVTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase 2, Heme B farnesyltransferase 2, Heme O synthase 2.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KAD_YERPE
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGLKAKEIMDAGKLVTDELVIALVKERITQEDCRDGFLLDGFPRTIPQADAMKEAGIKVDYVLEFDVPDELIVERIVGRRVHAASGRVYHVKFNPPKVEDKDDVTGEELTIRKDDQEATVRKRLIEYHQQTAPLVSYYHKEADAGNTQYFKLDGTRNVAEVSAELATILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_AROAE
Sequence: MADYRKTLNMPDTPFPMRGDLAKREPGWVADWQAKKLYQKVRKAAAGRPKFVLHDGPPYANGDIHIGHAVNKILKDIIVRSKTLAGFDAPYVPGWDCHGLPIEHQIEKQHGKHLPADRARELCREYAAEQIERQKKDFIRLGVLGDWDNPYRTMNFSNEADEIRALGELFRKGFLFKGLKPVNWCFDCGSALAEAEVEYQDKKSPAIDVGFPLVDNERDKLAHAFGLDTLPEQPVYIVIWTTTPWTIPSNQALNVHPELIYELVETPKGLLILAAELRASALERYQLEGRVLAAARGVALDRINFRHPFYDRLSPVFLGDYVAADAGTGIVHSAPAYGLDDFVSCTRYGMRNDEILNPVQADGTFAGSLPFFGGLSVWDANPKIVDKLAEVGSLFASGTLTHSYMHCWRHKTPVIYRATTQWFVGMDRLPGREAVEPGSATLRELALKAVDETQFYPAWGKARLHSMIANRPDWCVSRQRNWGVPIPLFLHKETGEPHPRSLELLEQVAQRVEQHGIDAWFKLDAAELLGSDVAQYDKMRDTLDVWFDSGTTHWTVLRGSHAADSQWPAALYLEGSDQHRGWFHSSLLTGCAIDGRAPYDALLTHGFVVDGQGKKMSKSKGNVVAPQEVSDKLGAEILRLWVAATDYSGELTISKEILDRVVEVYRRLRNTLRFLLANTGDFDIARDGVPVEEWLDIDHYALALTRRLQEQVTGDYARFEFHKIVQALQNFAAEDLGAFYVDILKDRLYTTKADSRARRAAQTALWHITQAITRMMAPILTFTAEEIWRVTGNDAEDSVMLHTWHELPELGASDEILARWELIRSARAEVQKVLESLRSDGRIGASLQAEVRVRASGARFDALASVGADLHFVLITSRAELVRVETEADEGVDAAPSSHQKCGRCWHFREDIGVDADHPELCGRCCTNLHGDGESRTHA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_CLAM3
Sequence: MYEGIVQELIDELGRLPGIGPKSAQRIAFHILQTETFDVSRLAEVLTVVRDKVRFCAICGNVSEKETCGICRDPRRSPATICVVEEAKDVVAIERTREFRGLYHVLGGAISPIDGIGPDDLRIRQLMQRLADATVTEVIIATDPNLEGEATATYLSRLLSTFDIRVTRLASGLPVGGDLEYADEVTLGRAFEGRRLVGE
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RECA_LEGPL
Sequence: MEENKQKALSAALSQIERQFGKGSVMRMGDSTVSRDIEAISTGSLGLDIALGIGGLPKGRIVEIYGPESSGKTTLTLQVIAECQKMGGTAAFIDAEHALDPSYAQKLGVKVDELLVSQPDTGEQALEITDMLVRSAAVDVVIIDSVAALTPKAEIEGEMGDSHVGLQARLMSQALRKLTANIKRSNTLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGSIKKGEEILGSETRVKVVKNKVAPPFKMTEFDILYNEGISRESEIINLGVQLNLIEKSGAWYSYKQEKIGQGKENVRLYLKENPQVAAELEQQIRTELLEKKLSVLASASEDLFETIDD
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREG_ECO5E
Sequence: MNIIKQPLRVGVGGPVGSGKTALLEALCKSMRDTWQLAVVTNDIYTREDQRILTEAGALEAERIVGVETGGCPHTAIREDASMNLAAVEALSEKFGNLELIFVESGGDNLSATFSPELADLTIYVIDVAEGEKIPRKGGPGITKSDFLVINKTDLAPYVGASLEVMERDTLRMRGERPWGFTNLKSGEGLQNIIAFIEEQGMLGK
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_PROM3
Sequence: MDPSAESIAGVDEVGRGCWFGPVFAGAVVLTEVAAVELLAEGLTDSKALTVRRRARLVPLIEDAATAWALGQASAREIDALGIRSATELSMLRALQRLPTPLELVLVDGVLPLRLWMGPQRTVVRGDSKCAAIAAASVLAKQARDGLIKRLASRFYGYGLERHVGYGTAIHRRALLDLGPTALHRRSFLTKLFAVHGSLT
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_ALTMD
Sequence: MNIILLDKIANLGGLGDQVTVKSGYARNFLFPQGKAVPATKDNVEKFEARRAELEAKIAEQLAAANARAEKVAELAEVTIAAPAGDEGKLFGSVGTRDIADAITAAGVEVQKAEVKLPTGTLRETGEYDIDLQLHSDVITSIKVIIIAEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RL5_STRPB
Sequence: MANRLKEKYTNEVIPALTEKFNYTSVMAVPKVEKIVLNMGVGDAVSNAKNLEKAAAELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEISFDDVDKVRGLDIVIVTTANTDEESRELLKGLGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ADH2_ORYSI
Sequence: MATAGKVIKCKAAVAWEAGKPLSIEEVEVAPPQAMEVRVKILYTALCHTDVYFWEAKGQTPVFPRILGHEAGGIVESVGEGVTELAPGDHVLPVFTGECKECDHCKSEESNMCDLLRINVDRGVMIGDGKSRFTIKGKPIFHFVGTSTFSEYTVIHVGCLAKINPEAPLDKVCILSCGFSTGFGATVNVAKPKKGQTVAIFGLGAVGLAAMEGARLSGASRIIGVDLNPAKFEQAKKFGCTDFVNPKDHSKPVHEVLIEMTNGGLDRAVECTGNINAMISCFECVHDGWGVAVLVGVPTKDDVFKTHPMNFLNEKTLKGTFFGNYKPRTDLPNVVELYMKKELELEKFITHSVPFSEINTAFDLMLKGESLRCVMRMDE
What are the official names of this protein?
Alcohol dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_BRUAB
Sequence: MVTVLNTVNQSGRLRHPEKAHRPDNEVLKKPDWIRVKAPVSRGYGETREIVRSNKLVTVCEEAGCPNIGECWEKKHATFMIMGEICTRACAFCNISTGIPNALDPNEPENIAKAVKQMGLTHVVITSVDRDDLADGGAHHFAEVIKAVREAAPATTIEILTPDFLRKEGALEIVVKARPDVFNHNLETVPSKYLKVRPGARYFHSIRLLQRVKELDPTIFTKSGIMVGLGEERNEILQLMDDLRSADVDFMTIGQYLQPTRKHHPVIRFVKPDEFKSFETIGKTKGFLLVASSPLTRSSHHAGEDFAKLKAAREALYASRAS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_HV1RH
Sequence: MRVMEMRKNCQHLWKWGTMLLGMLMICSAAEDLWVTVYYGVPVWKEATTTLFCASEAKAYKTEVHNVWAKHACVPTDPNPQEVLLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDANLNGTNVTSSSGGTMMENGEIKNCSFQVTTSRRDKTQKKYALFYKLDVVPIEKGNISPKNNTSNNTSYGNYTLIHCNSSVITQACPKVSFEPIPIHYCTPAGFAILKCNDKKFNGTGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSENFTDNVKTIIVQLNASVQINCTRPNNNTRKSITKGPGRVIYATGQIIGDIRKAHCNLSRAQWNNTLKQVVTKLREQFDNKTIVFTSSSGGDPEIVLHSFNCGGEFFYCNTTQLFNSTWNSTEGSNNTGGNDTITLPCRIKQIVNMWQEVGKAMYAPPISGQIKCISNITGLLLTRDGGEDTTNTTEIFRLGGGNMRDNWRSELYKYKVVRIEPLGVAPTRAKRRVVQREKRAVGTIGAMFLGFLGAAGSTMGAGSITLTVQARHLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTTVPWNASWSNKSLNMIWNNMTWMQWEREIDNYTGIIYNLLEESQNQQEKNEQELLELDKWANLWNWFDITQWLWYIRIFIMIVGGLVGLKIVFAVLSIVNRVRQGYSPLSFQTHLPAPRGPDRPEGIEGEGGERDRDRSGGAVNGFLTLIWDDLWTLCSFSYHRLRDLLLIVVRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNTTAIAVAEGTDRIIEVAQRILRAFLHIPRRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: ACON_ARTBC
Sequence: MLTTLARASAMLLGARGFASAADLDKKVEMTNWEKGNYINYKKMAENLDIVRARLNRPLTFAEKILYSHLDDPHGQEIERGKSYLKLRPDRVACQDATAQMAILQFMSAGMPSVATPATVHCDHLIEAQLGGDKDLARANEINKEVYDFLSTSCAKYNIGFWKPGSGIIHQILLENYCFPGGLMIGTDSHTPNGGGLGMAAIGVGGADAVDVMAGLPWELKAPNVIGVKLTGQMSGWTAPKDIILKVAGILTVKGGTGAIIEYHGDGVNSLSCTGMGTICNMGAEIGATTSVFPFNDRMYDYLKATKRQSIGDFSRVYAEGLRPDENAQYDQLIEINLSELEPHINGPFTPDLATPISKFKEAVKENNWPSELKVGLIGSCTNSSYEDMSRAASIARDALNHGIKAKSLFTVTPGSEQIRATIERDGQLKTLEEFGGVILANACGPCIGQWDRKDVKKNEANSIISSYNRNFTGRNDANPATHAFVTSPDLVVALTIAGTLNFNPLTDKLKDKDGNEFMLAPPTGEGLPANGYDPGRDTYQAPPADRASISVAVSPSSDRLQILEPFKAWDGKDAKGIPILIKCEGKTTTDHISMAGPWLKYRGHLDNISNNLLIGAVNAENGERNSVKNFETGEYDSVPATARAYKARGIPWVVIGDWNYGEGSSREHAALQPRHLGGMAIITRSFARIHETNLKKQGMLPLTFADPADYDRIPPTAMVDLMCTELAVGKPMTLRVHPKDGASFDVKLSHTFNESQIEWFKNGSALNTMAKKAQ
What is the function of this protein?
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
What are the official names of this protein?
Aconitate hydratase, mitochondrial, Aconitase, Citrate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.