PharMolix/UniProtQA huggingface dataset:
Protein: RPOZ_ECO55
Sequence: MARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGRR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: Y06K_BPT4
Sequence: MRDSRQPVIRSSPSAVMGKYRNGQFMCHGMAQTYRAYREEMRTFLTGPYLSLMNAFTHHSDARVEEICKNEYIPPFEDLLKQYCTLRLDGGRQSGKSIAVTNFAANWLYDGGTVIVLSNTSAYAKISANNIKKEFSRYSNDDIRFRLFTDSVRSFIGNKGSKFRGLKLSRILYIIDEPVKSPDMDKIYSVHIDTVHYCCNSKCCIGGITRPQFFVIGMQ
What are the official names of this protein?
Uncharacterized 25.0 kDa protein in regB-denV intergenic region.
Protein: RL15_METST
Sequence: MIRKTKKIRKQRGSRSVGGGCTKKRRGAGHRGGRGQAGGNKHHWTWMVINDPKHFGKYGFKRPQKTIQQFKPINLSVIDNNIEKLLADEIAVKEDGQIVLDVTQLGYNKVLGKGSLSTAITIKAPKFSQSAISKIEDAGGIAEII
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: AN32E_MOUSE
Sequence: MEMKKKINMELKNRAPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDDDEDGDEDEEDEDEDEAGPPEGYEEEEDDDEDEAGSEVGEGEEEVGLSYLMKDEIQDEEDDDDYVDEGEEEEEEEEEGLRGEKRKRDAEDDGEEDDD
What is the function of this protein?
Histone chaperone that specifically mediates the genome-wide removal of histone H2A. Z/H2AZ1 from the nucleosome: removes H2A. Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions.  Not involved in deposition of H2A. Z/H2AZ1 in the nucleosome.  May stabilize the evicted H2A. Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511).  Inhibits activity of protein phosphatase 2A (PP2A).  Does not inhibit protein phosphatase 1.  May play a role in cerebellar development and synaptogenesis.
What are the official names of this protein?
Acidic leucine-rich nuclear phosphoprotein 32 family member E, Cerebellar postnatal development protein 1, LANP-like protein, LANP-L.
What is the protein family that this protein belongs to?
Belongs to the ANP32 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EQTN_MOUSE
Sequence: MDFILLIILSGVFLPDIISLQPIVGQEPGVTLSDEEQYYADEENNTDGNSVALHKLEENEMDTPANEKTGNYYKDIKQYVFTTPNIKGSEVSVTATTNLEFAVKKNYKASKPTASGEEEKPSESSRKTSTPNIPAFWTILSKAVNETAVSMDDKDQFFQPIPASDLNATNEDKLSELEEIKLKLMLGISLMTLVLLIPLLIFCFATLYKLRHLRDKSYESQYSINPELATLSYFHPTEGVSDTSFSKSADSNSYWVHNSSEMRRSRTRRSKSKPMDFSAGSNQTVLTDESSFLPPEETRFLLPEEPGKELIVERGPMQAMNEIDAQLLLNKEGSPSN
What is the function of this protein?
Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.
What are the official names of this protein?
Equatorin, Acrosome formation-associated factor, MN9 antigen.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Single-pass type I membrane protein. Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm.
Protein: METB_HELPY
Sequence: MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG
What is the function of this protein?
Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction.  In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).
What are the official names of this protein?
Cystathionine gamma-synthase, CGS, O-succinylhomoserine (thiol)-lyase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEIP2_DANRE
Sequence: MQVNDGPSSHPIFVAPVNGNAQRSSGYVPGRIVPVRSPPPAKAPPPPPLKPPVPPPARPSVFNLSEDGNRREQAQNQQRKNTYICVGIFFGIFLLILILVLSLTSKDVLDENCPHQNPALRSWKPGHDLKKVVVIHSGEHYRLDSSATLYSITIQAGGSVVFADDKKGSKNITLRTRHILIEDGGALHIGAPKCRYRSLATITLVGRSDETAVTEVPGMGRKFLGVNSGGTLELHGSERMSWTFLTRTVPASGLATGDHAFQKNFSRGINLRVVDQDTAEVLVNERFDTHESQDDSKRLGELLKALPAGRIVALATGDSAVKNLVFETKQTIHDLLGSNYISDLKYRDAWALVSVIGGGNGSCTEDVREHENHDTGGKALARQDFFTVDGVGFTVTAYSEWSNGYPTTGFQVDAVDKVVLNLQDDVSSWNPGDRIVVASTDYSMYQAEEFTLLPCPNCNRKQVQIQGKPQFSHVGEILDGVDMRAEVALLSRNILIHGEMENSCYGGNWCQYFSYDTFGGHIKILGNFTSVHLSHIELKHMGQQREKGRYPLNFHRCGDVDQSGGYSNPAYVDSLSIHHSFSRCVTVHATNGLLVKDTVGYDTLGHCFFLKDGIEQRNIFFHNLGLLTRPGTILPTDRNDSMCTEITDRVYKGYIPIPANECKAVSSFWIAHPNNHLISNSAAGSQDAGIWYVFHNSSTGDSHGMISETKAELTPLGTFFNNRVHSNFKAGLFIDRKVKSTNATAADPREYLCLDNSARFRPHESSDPSRPRVAAIIDTLISFKNNDLGAWIRGGDIIIRNSGDGSYPKDEGSSQEVSQSLFIGESRNRGTNGGQNKYWGIGGVDGKMRTLPRNKTFPIRGFQINDGPVRIFDSTFRAFSPTADRFTMAVGFSLKNIWQLTPRNNLSALAFHPSVTLRAFFGRPGDWFEQNDLDGDKNSIFHDLDGSISGYADTYVARADNFLIRHPQCVDMPQWNGVVCSGKYSQVYIQTQAASNLSLSISRDEYPDKPMVLRGIRTKTSPSQQYQPVLMMGKSYTMHWNGPAPRETVLSLINFDQDDWALLGLCYPNETVFQITSDIYNKQNNGFEGIEDYGPVTSIADLEKRQQERKYFFDKSAGLLWLYARARHRRDGNSYCSSAGCERVKIIATIRANQKTETCNCTANAYPKYSKPASNIVPMPKPNTEPCGACGASQFAFSSDPWNSYLQTQIKSLSVKEEQDNDTQAYITVNAQRFDLSQSGFLLVTVDACSGKVTKNSMFSSLDTKMEQFFKTGIMKRSIVLLATRGQPASFAGVAQYLESLGSAKTPDLQNKVAIAFFGFLGQGGPSPQPWSTLLTCQGAKILGLQERFIPLSLEEYSCPPKKDSPTRMDLELLKKIS
What is the function of this protein?
Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan (PubMed:28118600).  Acts as a regulator of angiogenesis in embryos by mediating degradation of extracellular hyaluronan, thereby promoting VEGF signaling (PubMed:28118600).  Acts as a regulator of heart development during myocardial and endocardial morphogenesis: involved in the looping stage of heart morphogenesis (PubMed:21896629).  Stimulates migration of endocardial cells and increases both myocardial and endocardial fusion (PubMed:21896630).  Involved in the restriction of endocardial cushions (ECs) formation to the atrioventricular canal (AVC) (PubMed:21896630).  Also required for muscle fiber attachment (PubMed:27471259).  Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (By similarity).
What are the official names of this protein?
Cell surface hyaluronidase, Cell migration-inducing hyaluronidase 2, Protein frozen ventricle, Protein wickham, Transmembrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the CEMIP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: MSCL_AGRRK
Sequence: MLNEFKAFIAKGNVMDLAVGVIIGGAFGGIVKSLVDDIIMPIVGAIFGGFDFSNYFLGLSSAVNAPTLAGARAQGAVLAYGSFITVLINFLILAWIIFLMVKGVNTLRAQVERKDNKVAEAAPPPADVQLLTEIRDLLAKR
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THIC_PSEAE
Sequence: MSATQKNNITRLEQLDRQSTQPFPNSRKVYLTGSRPDIRVPVREISLADTPTAFGGEKNPPVFVYDTSGPYTDPEVRIDLRKGLPDVRSRWIDERGDTEILPGLTSEFGQARLADASLDALRFAHVRTPRRAKPGANVSQMHYAKKGIITPEMEYIAIRENMKLQEARAAGLLDQQHPGHSFGANIPKEITPEFVREEVARGRAIIPANINHTELEPMIIGRNFLVKINGNIGNSALGSSIEEEVEKLTWGIRWGADTVMDLSTGKHIHETREWILRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHQENFLYTHFEEICEIMKAYDVSFSLGDGLRPGSVADANDAAQFGELETLGELTKIAWKHDVQVMIEGPGHVPMQLIKENMDKQLECCDEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKDDVKTGIITYKIAAHAADLAKGHPGAQIRDNALSKARFEFRWEDQFNLGLDPDTARAFHDETLPKDSAKVAHFCSMCGPKFCSMKITQEVRDYAKENGLSDESKAIEAGFQEQAARFKDEGSVIYRQV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: RS12_ACIC5
Sequence: MPTFSQLVRKGRTAPRYKTASPALQGSPQRRGVCTRVYTQTPKKPNSALRKVARVRLTNGIEVTTYIPGIGHNLQEHSIVLIRGGRVKDLPGVRYHVVRGTLDSVGVANRKQGRSKYGAKRAKGGAAAGKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RS19_YERPS
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPIRTWSRRSTVFPNMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: YEGS_PSE14
Sequence: MTQRRAMLILHGKQALNEDVRDAVADKRKQGWELDVRLTWEAGDARRLVGEALAAGHRHIVAGGGDGTLRDIAEALALAETQASLTILPLGTANDFARAAGVPLEVSKALQLMDVAPRAVDLGEVGGKLFLNMATGGFGSQVTANTSEDLKKVLGGAAYLFTGLTRFSELHAAHGELTGPDFHWRGDLLALGIGNGRQAGGGHELCPTALADDGLLDISILPAPQEVVGTLRSLLEGGLGIDNMFIRTRLPWVELKSAQGLDINLDGEPLSGEDLRFEARPGALQVHLPADSPVLSRAPMLNRPD
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS-like.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_RICPR
Sequence: MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDKNFLMEYDISDKAGKYVDAIVKEARKAEVVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIMNAVANPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKSEEYWDISLKMQNSNNDLFTAKLTHVNDQKLKKFSIINEKEAKDLTQKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGNQYLPIKPRIYQSKVKNAQEAHEAIRPTNITYTPDSLKQKLEKDYYKLYELIWHRTIACQMENVIMDLVIANLASENKEYLAKANGSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKEQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTALNNFWRGFNHNIESVNEQKITEIINYLQKALDYHLFGEDKESKVCPSCKTGQLSLKLGKFGAFLACSNYPECTFKKSIVSGNDNNEDEGDPSTILNDNKILGTDQDGVEIYLKKGPYGPYIQLGEQCGKVKPKRTPVPANLKQSEITLEIALKLLNLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLSLNDAMKLIQNNKAKLEKKYG
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: NUDL_PECAS
Sequence: MPPTAFALNDFITRFQLQLPPSLRPVHQQRQAAVLVPIICHPTPTLLLTRRSADLRKHAGQVAFPGGAADKTDRSIIETALREAQEEVAIPPENVQVLGVLPPLDSVSGFQVTPVVGLIAAQTRFHPNEDEVAELFEMPLDEAFALTRYYPLDIERKQQRHRVYLSWYQQQFVWGLTAAIIHQLALQISDRP
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: RUTC_ECO8A
Sequence: MPKSVIIPAGSSAPLAPFVPGTLADGVVYVSGTLAFDQHNNVLFADDPKAQTRHVLETIRKVIETAGGTMADVTFNSIFITDWKNYAAINEIYAEFFPGDKPARFCIQCGLVKPDALVEIATIAHIAK
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: BIOF2_BACVZ
Sequence: MDFDGWLLGRLDAVKRDGLYRTLRTQETALKTKGQKRQTWASNDYLGLSKDERLITAAQTAMSRFGAGSGGSRLTTGNTVWHEKLEHTIADFKQTEAALLFSSGYLANIGVLASLPQKGDVILSDQLNHASIVDGCRLSKAETIVYRHIDMADLEKKLASVQARNRRFIVTDGVFSMDGTIAPLDRIMALAKQYQAFVIADDAHATGVLGENGGGTSDYFGVCPDVVIGTLSKAVGTEGGFAAGSNIFIDFLLNQARTFIFQTALPPSICAASHTAFDIISDMHDTRRELQSSVKMIKTRLADMGFTVRGGDTPIIPVIIGDAKTAVSAAALLEKKGICAPAIRPPAVPEGESRIRLTVTADRSLQDIDELTEAFDSIRKELNINK
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase 2, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: CYB_HAPAU
Sequence: MTNIRKNHPLMKIMNSSFIDLPAPSNISSWWNFGSLLGACLALQIITGLFLAMHYTADTTTAFSSVTHICRDVNYGWVIRYLHANGASMFFLCLFIHIGRGLYYGSFTLSETWNVGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALVMVHLLFLHETGSNNPLGTSSDSDKIPFHPYYTIKDLLGLVLLALLAMTLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILAIIPMLHTAKQRSMTFRPLSQYMFWILTADLFILTWIGGQPVEYPLITIGQMASILYFSLILIVMPMVGLIENNMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NADE_SHEAM
Sequence: MKGQILREMRVLKAITPDFEVQRRVAFIKAKLREAHSKTLVLGISGGVDSSVAGRLCQLAVNELNQETDSQQYRFIAVRLPYLVQKDEHEAQMACEFIQPSKLVTVNVGSGSDGIHTETLTGFKAAGLELPEASKVDFVKGNVKARMRMIAQYEIAGLTGGLVVGTDHSAENITGFYTKWGDGACDLAPLFGLNKRQVRQIARYLGAPDVLVVKAPTADLECHRPGLEDEVALGLTYDQIDDFLEGKEVPRSAEDKLIGIYKATQHKRQPIPTIYD
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: CLPP1_SYMTH
Sequence: MSYLIPYVIEQTNRGERSYDIYSRLLKDRIVFLGTPIDDQVANVVIAQLLFLESEDPDKPVNLYINSPGGSVSAGLGIYDAMQHIKSPVNTTVVGMAASMAALLLAAGTGKRYALPNARVMIHQPHLSGVGGQVTDIEITAREAVKTKQLMAEILAKHSGQSVERILADTERDRWMSAQEAVEYGLVDEVLHPREKASRSAR
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABV_SHEAM
Sequence: MIIKPKIRGFICTTTHPVGCEANVLEQINLTKARGPIVNGPKRVLVVGSSSGYGLSSRIAAAFGSGAATIGVFFEKPGTESKPGTAGWYNSAAFDKFAKAEGLYSKSINGDAFSHEAKAKAIELIKADLGQIDMVVYSLASPVRKLPDSGELVRSSLKPIGQPYSSTAVDTNKDTIIEASVEPATEQEIADTVTVMGGQDWELWLNALDEAGVLAEGCKTVAYSYIGTELTWPIYWHGALGKAKMDLDRAAHALNDKLAAKGGSANVAVLKSVVTQASSAIPVMPLYIAMVFKKMRAEGLHEGCMEQILRMFSERLYKADGSAPEVDEDNRLRLDDWELRDDIQQHCRDLWPQITTENLPELTDYFEYKAEFIKLFGFGIEGIDYDADVNPEVNFDVIEL
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: THIO2_ECOLI
Sequence: MNTVCTHCQAINRIPDDRIEDAAKCGRCGHDLFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAQERSGKVRFVKVNTEAERELSSRFGIRSIPTIMIFKNGQVVDMLNGAVPKAPFDSWLNESL
What is the function of this protein?
Efficient electron donor for the essential enzyme ribonucleotide reductase.  Is also able to reduce the interchain disulfide bridges of insulin.
What are the official names of this protein?
Thioredoxin 2, Trx-2, Protein-disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERB1_CANAL
Sequence: MARNSIKKSPVVKKKDTPIVRKRKPIQQEAEEDSNDEESEDELNVEGLIDASDDEDEEEEQEQEEQPQEEENNSDDDDDDDDDDDDNNSEADSEEELNQLLGEEEEEDPSDYNSDEFSDEPKDDDLSRINIKSLSVSDPSIQKNSISKFSDGSIRILKPEIEPKYDSDDSDAENFNTIGNIPISAYDEMPHIGYDINGKRIMRPAKGSALDQLLESIDLPEGWTGLLDQNTGTSLKLTDEELELIRKIQQQENTDENINPYEPLIDWFTKDEEIMPVTAVPEPKRRFVPSKHEAKRVMKIVKAIREGRIIPPNKVKQQLTEEEEEDQFNFDLWQDEIEISDHIMNLRAPKLPPPTNEESYNPPEEYLLTEEEKSKWLQESPIDRERNFLPQKYNSLRQVPGYQDSVRERFERSLDLYLAPRVRHNKLNIDPDSLIPDLPSPKDLRPFPIRCSTIYEGHTGKIRTISIDPQGLWLATGSDDGSVRIWEILTGRQVYKIQLINKEINNEDHIECLEWNPDSSCGILAVCVGENIYLIVPPIFGFDIENSGKLRIESGWGYDTFGNKKKDLKISSQKEEDNKESDNEDEDEEEDNDDDDDDDEPETSSTVEPKKEVAKWYPPNTEQASMGISAIIQCRKTIKKLSWHRKGDYFVTVSPDSKNTAVLIHQISKHLSQSPFKKSKGIIMDAKFHPFKPQLFVASQRQIKIYDLAQQVLLKKLMPGVRLLSTIDIHPRGDNLIAGSYDKRVLWHDLDLSATPYKTLRYHEKAVRSIKFHKGNLPLFASASDDGNIHIFHGTVYDDLMTNPLLVPLKKLNGHKIINQIGILDLIWHPKEPWLFSAGADGTARLWTT
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein ERB1, Eukaryotic ribosome biogenesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: CSK2A_SCHPO
Sequence: MNQTEAAPVVSVSRVYAHVNEEMPREYWDYENMQEVFGYQDNYEIIRKVGRGKYSEVFEGLNVLNNSKCIIKVLKPVKYKKIKREIKILQNLAGGPNIISLLDIVRDPESKTPSLIFEFVDNIDFRTLYPTLSDYDIRYYSYELLKALDFCHSRGIMHRDVKPHNVMIDHKKRKLRLIDWGLAEFYHAGMEYNVRVASRYFKGPELLVDFREYDYSLDIWSFGVMFAALIFKKDTFFRGRDNYDQLVKIAKVLGTDELFAYVQKYQIVLDRQYDNILGQYPKRDWYSFVNRDNRSLANDEAIDLLNRLLRYDHQERLTCQEAMAHPYFQVLK
What is the function of this protein?
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
What are the official names of this protein?
Casein kinase II subunit alpha, CK II subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Protein: GLMS_BORPE
Sequence: MCGIVGAVAQRDITPILIEGLKRLEYRGYDSCGVALYMDGHLRRTRSTKRVAELSEQVAEDKLGGFTGIAHTRWATHGIPATYNAHPHFSAQGKDEPRIALVHNGIIENHEELRQELQGVGYVFESQTDTEVIAHLVNHLYAGDLFEAVQQAVRRLQGAYAIAVFCRDEPHRVVGARQGSPLVVGLGQNENFLASDALALAGTTDQIIYLEDGDVVDLQLARVWIVDQAGKQVERKAHTVQVHTGAAELGPYRHFMQKEIFEQPRAVGDTLQDIESITPELFGDGAYKVFKEIDSLLILACGTSYYAGLTAKYWIESIARIPVAVEIASEYRYRDSVPNPNALVVTISQSGETADTLAALKHVRSLGMQHTLTVCNVVTSAMVRECELAYITRAGVEIGVASTKAFTTQLTALFLLTLALAQTRGRLTEEQEAEHLKALRHLPAAIGAVLALEPQIMAWADRFASKENALFLGRGMHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEHMPVVTIAPKDALLEKLKSNMQEVRARGGELYVFADADSKIANAEGMHVIRMPEYYGALSPIVHTIPLQLLSYHTACVRGTDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_EHRCR
Sequence: MLNSYVVREVSNDKLKWEYEFAVDKKYFLDQLDSKLSEIAMNVKVPGFRVGKASIDLVRKEYLNEAMTSVVKKTIESTSSDFVKNSKFGEIISSNIDIVSYPSYYSDNDKEEDLVYKLSFEVMPEAPLMDIDNIVLSDIEVDIQECDVNEFIENLKKQRPDFVIVDDPEYVIQGSDKLVIDYQNKIKGKILRGGSAKDFVLVLGKGVALREFEDQLIGMKVGESKTFPLTFPNDYGMVHLAGKTTDMSVTVKSVYVMKGMRDSEAIAKDYGFKDVGHMEDFARKRIKQQFDQMVFTIVKKELFDYMDANYVIDVPECVVTQEIAKINKEIRDSGEDIQIDVEKEAIKRVKLGMLLIKMSRHNNITIKNEDVFSFIQSNYADYGVDIGNVLKMLQSNKNFANYISGKVLEEKVINYIIGLAKKDKKVMTAKDISLMFENI
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: H9C01_CYRHA
Sequence: MKSIVFVALFGLALLAVVCSASEDAHKELLKEVVRAMVVDKTDAVQAEERKCRWYLGGCSQDGDCCKHLQCHSNYEWCVWDGTFSK
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
Omega-theraphotoxin-Hhn1b, Omega-TRTX-Hhn1b, Hainantoxin-IX-3, HNTX-IX-3.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 17 (Hntx-9) subfamily.
What are the subcellular locations of this protein?
Secreted.