PharMolix/UniProtQA huggingface dataset:
Protein: BURS_APIME
Sequence: MLLYHIVGASVLICLLNETAKAIIGVDECQATPVIHFLQYPGCVPKPIPSYACRGRCSSYLQVSGSKIWQMERSCMCCQESGEREASVSLFCPRAKPGEKKFRKVITKAPLECMCRPCTSVEEYAIIPQEIAGFADEGPFTTSAHFRRSSDLQ
What is the function of this protein?
Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading.
What are the official names of this protein?
Bursicon, Bursicon subunit alpha, Single-chain bursicon.
What are the subcellular locations of this protein?
Secreted.
Protein: RL39_SULIK
Sequence: MSRNKPVAKKFRLAKALKANSPIPIWIVLKTRGRVRYNPLRRNWRRNDLKV
What are the official names of this protein?
50S ribosomal protein L39e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: MNMG_GLUOX
Sequence: MSDFDVIVIGGGHAGCEAAAASARFGARTLLLTHRLETIGAMSCNPAIGGIGKGHLVREIDALDGLMGKAADRAGIHFKLLNRSKGPAVHGPRAQADRSLYRAAIQDLLAATPNLTILEGAAGDLIEENGRITGVICEDGREFRCGAVVLTTGTFLRGVIHVGHTQTEAGRIGEAPAKRLGERLYALGLQMGRLKTGTPPRLARDSIDWDNLPADPGDAEPEAFSPMTTAIINPQVVCRISHTTAETHRIINENLHRSAMYGGAIAGRGPRYCPSIEDKVVRFAERTSHQVFLEPEALPGNPGGDLVYPNGISTSLPADVQAAMIATMPGLENARIVTAGYAVEYDYVDPRELLPSLQLRRLPGLYLAGQINGTTGYEEAGAQGLLAGLNAARATAGNEPLTLDRSDAYLGVMIDDLTLHGISEPYRMFTSRAEYRLTLRADNADLRLTPKGIAAGCVLPEREAAFTAQKAELDAAMARAAETTFLPQTLRDVGFEVSLDGRRRTVLDVLASNGDHTKLDTLAPWFAELPLRVRRHVETEARYDGYLHRQDREIRQLASESAIALPADLDYTAIGGLSSEMRERFSQARPTSFAAAQRVRGVTPAALVALLAHVRTLS
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBX_PROM1
Sequence: MAFHLLNLFLSAGTSSEAATSSAVGMIGSFLAAGALIVAPAAAALIWVSQKDALSR
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RCL1_BOVIN
Sequence: MASQAHSLSYSGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKVTNGSRIEINQTGTTLYYQPGLLYGGSMEHDCSVLRGIGYYLESLLCLAPFMKHPLRIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKVVRRGMPPGGGGEVFFSCPVRKVLKPIQLIDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGINSGKSPGFGLSLVAETTNGTFLSAELASNPQGQGAAMLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).  Does not have cyclase activity (By similarity).
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase-like protein.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TR19L_MOUSE
Sequence: MSLQGLMMKRTLLCWPLSCLFVLLPWPLATPTPITPWLCPPGKEPDPDPGQGTLCRTCPPGTFSASWNSYPCQPHYRCSLQKRLEAQAGTATHDTMCGDCQHGWFGPQGVPHVPCQPCSKAPPSTGGCDESGRRGRRGVEVAAGTSSNGEPRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAQKEVGPSPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVPRLLPASPSIPHICPHHHHLHTVQGLASLSGPCCSRCSQKWPEVLLSPEAAAATTPAPTLLPTASRAPKASAKPGRQGEITILSVGRFRVARIPEQRTSSLLSEVKTITEAGPSEGDLPDSPQPGLPPEQRALLGSGGSHTKWLKPPAENKAEENRYVVRLSESNLVI
What is the function of this protein?
May play a role in apoptosis.  Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed.  Involved in dental enamel formation (PubMed:30506946).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 19L.
What is the protein family that this protein belongs to?
Belongs to the RELT family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region.
Protein: DTD_BURO0
Sequence: MIALIQRVTRADVRVGGRTTGEIGAGLLALVCAERGDTEAAADKLLAKLLGYRVFSDAAGKMNLPVSNIDGEGRAGGLLLVSQFTLAADTNSGLRPSFTPAAPPDEGARLFDYFVAAARARHPIVETGEFGADMQVSLVNDGPVTFWLQVRP
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
Protein: KHSE_RHOP5
Sequence: MAVYTDVAADDLAEFLLAYDIGELLSYKGIAEGVENTNFLLHTSRGSFILTLYEKRVAAEDLPYFLSLMAHLASRGVSCPQPEKNRDGEICGTLSGRPAVIINFLEGVWPRRPNVAQCAGVGEALAKMHLAGRDFPLVRKNPLSVKGWWALFEQAASGADPLQHGLRALLHAELDHLDHAWPKHLPEGVIHADLFPDNVFFIGDKLSGLIDFPFACNDILAYDVAICLNAWCFEPDHSFNVTKARAFLNGYNRGRPLEAAEQDALPLLARGAALRFLLTRLVDSLNVPAGALVRPKDPLEYARKLRFHQSVNSIRDYGVETSGLVA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: TRIL_MOUSE
Sequence: MEGVGAVRFWLVVCGCLAFPPRAESVCPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALVPGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFSQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATFGHQGRLRELSLRDNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQLLQNGSCVDPSPSPTAGSRQWPLPTSSEEGMTPPAGLSQELPLQPQPQPQQRGRLLPGVAWGGAAKELVGNRSALRLSRRGPGPHQGPSAAAPGSAPQSLDLHEKPGRGRHTRANLSQTEPTPTSEPASGTPSARDSWQRAAKQRLASEQQESAVQSVSGVGLPPLVSDPCDFNKFILCNLTVEAVSANSASVRWAVREHRSPRPQGGARFRLLFDRFGQQPKFQRFVYLPERSDSATLHELRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTLPEAGGRGGVDYQLLTLVLLAVNALLVLLALAAWGSRWLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLIEFPCDRFMDSTGGGTSGSLRREDHLLQRFAD
What is the function of this protein?
Component of the TLR4 signaling complex.  Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion (By similarity).
What are the official names of this protein?
TLR4 interactor with leucine rich repeats, Leucine-rich repeat-containing protein KIAA0644.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: NDUA6_ARATH
Sequence: MAAPFALRKIGVPPNSANLTEARRRVFDFFRAACRSIPTIMDIYNLQDVVAPSQLRYAISAQIRNNAHITDPKVIDLLIFKGMEELTDIVDHAKQRHHIIGQYVVGEGLVQNTGNKDQGKTDFLKNFYTSNYF
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ASA1_NEUCR
Sequence: MAVEGRPPTPKSILRGHKAQVHAATFIRNNERLVTGDADGFVIAWDLTIMRPRAVWQAHDNAILGIAGWGNDRIITHGRDNKLIVWKLIGDDEARMSTTLPLDPCAEPRPKPWILHLLEVNTMNFCSFSYCPVSAPVLPGQQEGQSQDTAQESRFESELLIAVPNTLASEAIDIFHLPSQTRRHTVKLGDKNGMVMAVALFNQADSLTLVAGYENGLAIVAHRDPVKNDWVPLYQATCHSQPILSLSVSPARDFFLTSSADAVIAKHPLPSVVSQDTTSTHATTTQAAQVSESEESSSPVNTGDKAVGKSLLGAALAKEKQNPSSQPKRSLKPEEVLTHPLKTVNTKHAGQQSIEIRSDGLIFATAGWDSKIRVYSTKTLKEVAVLKWHQVGCYAVAFAHIAPNTGAPSINDQNPKATVSTTGTQPATSDSLGHGTQKPNMDQSLTVVPKLVELTVRDKRLRQAKAAHWLAAGSKDGKVSLWDVF
What is the function of this protein?
Component of the ASTRA complex involved in chromatin remodeling.
What are the official names of this protein?
ASTRA-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ASA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS9_XANAC
Sequence: MAITQNYGTGRRKSSTARVFLRKGTGNITVNDRPLDEFFGRETARMIVRQPLELTKNTESFDIMVTASGGGTTGQAGAIRLGIARALVEYDETLKSELRKAGFMTRDAREVERKKVGLHKARRATQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: AGRE1_HUMAN
Sequence: MRGFNLLLFWGCCVMHSWEGHIRPTRKPNTKGNNCRDSTLCPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSPQPCGPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVNSMGSYSCSCQVGFISRNSTCEDVDECADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTEMCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNALGSYSCGCIAGFHPNPEGSQKDGNFSCQRVLFKCKEDVIPDNKQIQQCQEGTAVKPAYVSFCAQINNIFSVLDKVCENKTTVVSLKNTTESFVPVLKQISTWTKFTKEETSSLATVFLESVESMTLASFWKPSANITPAVRTEYLDIESKVINKECSEENVTLDLVAKGDKMKIGCSTIEESESTETTGVAFVSFVGMESVLNERFFKDHQAPLTTSEIKLKMNSRVVGGIMTGEKKDGFSDPIIYTLENIQPKQKFERPICVSWSTDVKGGRWTSFGCVILEASETYTICSCNQMANLAVIMASGELTMDFSLYIISHVGIIISLVCLVLAIATFLLCRSIRNHNTYLHLHLCVCLLLAKTLFLAGIHKTDNKMGCAIIAGFLHYLFLACFFWMLVEAVILFLMVRNLKVVNYFSSRNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHNRCWLNTETGFIWSFLGPVCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRLLTFKAFAQLFILGCSWVLGIFQIGPVAGVMAYLFTIINSLQGAFIFLIHCLLNGQVREEYKRWITGKTKPSSQSQTSRILLSSMPSASKTG
What is the function of this protein?
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system.  May play a role in regulatory T-cells (Treg) development.
What are the official names of this protein?
Adhesion G protein-coupled receptor E1, EGF-like module receptor 1, EGF-like module-containing mucin-like hormone receptor-like 1, EMR1 hormone receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLGH2_YERPE
Sequence: MYLRKISAPLMTMLLLNGCAYIPHKPLVDGTTSAQPAPASAPLPNGSIFQTVQPMNYGYQPLFEDRRPRNIGDTLTITLQENVSASKSSSANASRNGTSSFGVTTAPRYLDGLLGNGRADMEITGDNTFGGKGGANANNTFSGTITVTVDQVLANGNLHVVGEKQIAINQGTEFIRFSGVVNPRTISGSNSVTSTQVADARIEYVGNGYINEAQTMGWLQRFFLNVSPY
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein 2, Basal body L-ring protein 2.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: PP11_TOBAC
Sequence: MAQNNEQQQQGQGLIEAGVLDDIINRLLEFRNARTVRQVQLSEAEIRSLCSASREIFLQQPNLLDLKPPIKICGDIHGQYGDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNVKLWKCFTECFNCLPVAALIDEKILCMHGGLSPVLTNLDQIRNLPRPTDVPDSGLLCDLLWSDPSREVKGWGMNDRGVSYTFGPDKVAEFLMQHDMDLVCRAHQVVEDGYEFFAERQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPTDRKPRFL
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1 isozyme 1.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
Protein: Y3385_KLEP7
Sequence: MKRTKNINHSSFRKSWSARHLTPVALAVTAVFMLAGCEKSDETVSLYQNADDCSAANPGKAAECTTAYTNAVKEAERTAPKYATREDCVAEFGEGQCQQTPAQAGVAPENQAQAQSSGSFWMPLMAGYMMGRLMGGGMAQQQPLFSSKNPASPAYGQYTDASGKSYGAAQPGRTMNVPKTAMAPKPATTTTVTRGGFGESVAKQSTMQRSAAGSTSSSRSMGG
What are the official names of this protein?
UPF0441 protein KPN78578_33850.
What is the protein family that this protein belongs to?
Belongs to the UPF0441 family.
Protein: TKNB_CHICK
Sequence: HKTDSFVGLM
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
What are the official names of this protein?
Neurokinin-A, Neuromedin-L, Substance K.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LPP4_ARATH
Sequence: MAKIMLGSHSVKSHGWKVAREHLCDWLILVVLGLIDIVLNVIEPFHRYIGPDMLTDLTFPFYEDTIPMWAVPIICILVPICIFIVYYYYRRDVYDLHHAILGIGFSCLVTGVTTDSIKDAVGRPRPNFFYRCFPNGKPKFHPDTKDVVCHGVKKIIKEGYKSFPSGHTSWSFAGLTFLAWYLSGKIKVFDRRGHVAKLCLVFLPILISILIGISRVDDYWHHWTDVFAGAIIGIFVASFSYLHFFPYPYDENGWAPHAYFRMLAERSTGRATTMTRTGSRGMLGNDVEPGNSASSPHDRHRESTDSDF
What are the official names of this protein?
Probable lipid phosphate phosphatase 4, AtLPP4, Phosphatidic acid phosphatase 4, AtPAP4.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TX1_BUTSQ
Sequence: VSIGIKCDPSIDLCEGQCRIRYFTGYCSGDTCHCS
What is the function of this protein?
Neurotoxin.  Decreases the action potential of myelinated nerves in mice and frogs.
What are the official names of this protein?
Neurotoxin.
What are the subcellular locations of this protein?
Secreted.
Protein: ROC8_ORYSJ
Sequence: MDFGDEPEGSDSQRRRKRYHRHTPRQIQQLEAMFKECPHPDENQRAQLSRELGLEPRQIKFWFQNRRTQMKAQHERADNCFLRAENDKIRCENIAIREALKNVICPTCGGPPVGEDYFDEQKLRMENARLKEELDRVSNLTSKYLGRPFTQLPPATPPMTVSSLDLSVGGMGGPSLDLDLLSGGSSGIPFQLPAPVSDMERPMMAEMATRAMDELIRLAQAGDHIWSKSPGGGVSGGDARETLNVDTYDSIFSKPGGSYRAPSINVEGSRESGLVLMSAVALADVFMDTNKWMEFFPSIVSKAHTIDVLVNGMGGRSESLILMYEELHIMTPAVPTREVNFVRYCRQIEQGLWAIADVSVDLQRDAHFGAPPPRSRRLPSGCLIADMANGYSKVTWVEHMEVEEKSPINVLYRDLVLSGAAFGAHRWLAALQRACERYASLVALGVPHHIAGVTPEGKRSMMKLSQRMVNSFCSSLGASQMHQWTTLSGSNEVSVRVTMHRSTDPGQPNGVVLSAATSIWLPVPCDHVFAFVRDENTRSQWDVLSHGNQVQEVSRIPNGSNPGNCISLLRGLNASQNSMLILQESCTDASGSLVVYSPIDIPAANVVMSGEDPSSIPLLPSGFTILPDGRPGSAAGASTSSAGPLAAARGGGGGGAGGGSVVTVAFQILVSSLPSSKLNAESVATVNGLITTTVEQIKAALNCSAHGHHP
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Homeobox-leucine zipper protein ROC8, GLABRA 2-like homeobox protein 8, HD-ZIP protein ROC8, Homeodomain transcription factor ROC8, Protein RICE OUTERMOST CELL-SPECIFIC 8.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class IV subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VE6_HPV27
Sequence: MRTRAGMSEENPCPRNIFLLCKQYGLELEDLRLLCVYCRRALSDADVLAFAIKELSVVWRKGFPFGACGKCLIAAGKLRQYRHWHYSCYGDTVETETGIPIPQLFMRCYICHKPLSWEEKEALLVGNKRFHNISGRWTGHCMQCGSTCTAPDPASRTLH
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: RPC3_KLULA
Sequence: MSAAQAALIPDAAVPNGGASVVSAAEPSTSTSPEPIDISSLEQRTLNPDSFLYSELARSHLGERASTVLSVLVNKGRLSTREIHSFIPELSLSSIKTVLVSLIQLRCVQYLEETSLSGRKTLYYYFNEEGLFLMLYAGDISDRIVQYFNQDEEQHLVNIAQQIIHNVLALGSLTVKDYLASESNSNDTDIFNIHQAFVRLADLEFLVPLQGIHYTPIVDLWNMLYLREYKKLPKNTTQSDLKKRNEAKAKAKLEFNRIVSSPSQDSNGKIFLTDSGTGFKKVNESVSLTFNLERYLKSRRSNQLVQFAKSRIGTTSSKIYAVALSMTEQHSNGLSHPLSKTGLFQDLDERTSLEEDLKLDEENVKGVSFTALDVARRLPSNLDLRGTLVHSNQSLKRKQKHNQSPPQFEKRIKTEDGFVVPPLPTVMEESEEENEEGDANLDLDEDDSDPRSVSLVNGHLRLLLTANIPFIKESKPGQFFVPYSSLIPILKSSTYDSIIASTLGPSSHRVLRCIRDNGLCTERTITTTSLMREKDVRTVIGTLVKYNAIEIQEVPRTVDRAASRAVFLFRIKEKHAFNTMKLNLTWNLARLISKLETLKEENATLLKKANRDDVKGREMELLLASEINQLKVVNDRELNGLVRRHRLLSLWEVFKLF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC3, RNA polymerase III subunit C3.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: M3K13_MOUSE
Sequence: MANPQEHLSCSSLPHLPLTENKTSGGRNELAAMGNHPSPKLPEDPQERGAIQSELMEITGSPISTTVLTSVSEDSRGQFENSVLQLREQDESEMTLSLGNSNTVDGENTNGPEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELLKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKAGVQTKRPDLLRSEGIPSTEAVPTASPLSGSPKMSTASSRSRYRSKPRHRRGNSRGSHSDFAAILKTQPAQENSPHPTYMHHTQAQCASVHQHNPLQQQYQQIPPAQPQSRHPRLNAHGQDIATCANNLRYFGPAAALRSPLSNHAQRQMPGSSPDLISTAMAADWRNSELDQDQVGPWGCCQAEPYDPCFQCRPEHSGSLDVPTTEPVGRSPDLSSSPAHNPLSGNAQGSERTGANGFSGCQSGISHQFTPPMLPQKTRPLQKSGDDSSEEEGEVDSEVEFPRRQRPHRCISSYQSYSTFSSENFSVSDGEEGNTSDHSNSPDESANRRQDRLAETLDDLLSQTPEAPIEISSHSDGLSDKECAVRRVKTQMSLGKLCAEERGYENPVQFGDSDCDSSEGECSDATVRTSKNYSSATW
What is the function of this protein?
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.  Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol.  This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 13.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: FEN1_CRYNJ
Sequence: MGIKGLTGLLSENAPKCMKDHEMKTLFGRKVAIDASMSIYQFLIAVRQQDGQMLMNESGDVTSHLMGFFYRTIRMVDHGIKPCYIFDGKPPELKGSVLAKRFARREEAKEGEEEAKETGTAEDVDKLARRQVRVTREHNEECKKLLSLMGIPVVTAPGEAEAQCAELARAGKVYAAGSEDMDTLTFNSPILLRHLTFSEAKKMPISEIHLDVALRDLEMSMDQFIELCILLGCDYLEPCKGIGPKTALKLMREHGTLGKVVEHIRGKMAEKAEEIKAAADEEAEAEAEAEKYDSDPESEEGGETMINSDGEEVPAPSKLKSPKKKAPAKKKKVASSGMQIPEFWPWEEAKQLFMKPDVVNGDDLVLEWKQPDTEGLVEFLCRDKGFNEDRVRAGAAKLSKMLAAKQQGRLDGFFTVKPKEPAAKDTGKGKGKATKGEKRKAEEKGSAKKKSKN
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: UVRC_MARMM
Sequence: MTSQTPQSGEIDDASAAPAQSLAGAKLIADYVRNLPPKPGVYRMFGEDGAVLYVGKARNLKNRVSNYANGRGHSNRIALMIGLTRKMEFVVTQTETEALLLEANLIKSLKPRFNILLRDDKSFPYILIRKDHPAAQLTKHRGARKAKGDYFGPFASVGAVNQTLNTLQKAFLVRTCSDSVYEGRSRACMLHQIKRCAGPCVDLIDPAAYDELVGQATDFLRGRSNALREDLQTRMAQASEAMDFETAAKLRDRIRAIAAVTTDQGINPDGVEEADVVAVHSDGGKSCVQVFFFRAGQNWGNQSFFPRHDMEAEPAEVLAAFIAQFYDDKPAPALILLSHEIEEAELLGEALSLRTERKVSLHTPRRGEKRKLVDRTLTNAREALARRMAESASQTQLLKGVQRVFDLTDLPQRIEVYDNSHIQGTNALGAMIVAGPEGFEKNHYRRFNMKGDDAATNDDFAMMKAMLKRRFSRLLKERDDGAPVPDLVLIDGGKGQLSSVMEIAEELGITDETGITIAAIAKGPERDAGREAFYLPGKPPFKLPMKDPVLYYLQRLRDEAHRFAIGGHRAKRKKQMTDNPLDGIDGIGPSRKKALLAHFGSAKAVRNAALADLEAVDGISRAMARKIHDWFQK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PHEIN
Sequence: MTIIRKKHPLIKIINHAFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTATAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGIYYGSYNMIETWNMGIMLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIVAMVLVHLLFLHETGSNNPSGLNSDADKIPFHPYYTIKDLLGALLLLMGLMILVLFFPDILGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALMPFLHTSKQQGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIMIGQVASIAYFTIIVILMPIAGMIENIILDLE
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FER_ACIIN
Sequence: GIDPNYRTSRQVVGEHQGHKVYGPVDPPKVLGIHGTIVXVDFDLCIADG
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Zinc-containing ferredoxin, Seven-iron ferredoxin.