PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_AYWBP
Sequence: MQNCDPIKQKIKSLVKQLNKANYQYYNLSDPDLSDQQYDALIKELINLENHYPQFKLPYSPTLKIGGFVEKKFSTIKHKTPMMSLANVFNIEELKAFYDRIVKKIPTFSLLTELKIDGVAISLKYQKGILVRALTRGNGIWGEDVTKNAQTIKTIPLRLNEDLDLEVRGEIYLSHPDFEKLNAQRKQENKPLFSNPRNAASGTLRQLNSAVVAKRNLSIFVYGIADPYLTKPTQKETLVFLTALGFATNPHHYFVSNFENLLSVIEKYKSIKEQLTYDTDGIVIKINELVFHSLIGATAKAPRWATAYKFATITSQSIIQNIIFQVGRTGVITPVCEIMPVMVDGSLVSKVFLHNYDYICKKDIRIKDHVIVHKAGSVIPEILEVIKSKRTDLQKPTLMIEKCPSCKTILEKQPGGIDYFCLNPNCREQKIQKLIHFVSKNAMDINVLGEQTIITFFDKNLITKPSDLYLLKNHQHILQEISGFGAKKITNILDAIEASKQKGFEDVLFALGIKHIGKKVSQVLAKYFQTIENLQQSTSDTITQIREIGIKIAQSIQQYFSNSCNLEEVTKLKKLGVSFQSTNSQKPTTQNIFTNKKIVLTGTLQKYSRLQIQQILEQMGAIITNSLSLKTNYLIVGINAGSKLTKAQKLQIPIIEEKELQQIIENNQIKS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: FMT_SHEPC
Sequence: MKSLNIIFAGTPDFAARHLQALLNSQHNVIGVYTQPDRPAGRGKKLTASPVKELAIANNIPVFQPGSLRKEPAQQELAALNADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGAAPIQRALWAGDKETGVTIMQMDVGLDTGDMLLKTYLPIEDNDTSASLYEKLAEQGPIALLQALEGLTNGTLAAEKQDEALANYAEKLSKEEARLDWNKSAKQLWQEVRAFNPWPVSYFEHQGNTIKVWQAHVSETISTAAPGTIISASKKGIEVATADGVLTLLSMQLPGKNPLNVADILNARGEWFSPNTRLANEAE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: CUSS_ECO57
Sequence: MVSKPFQRPFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSHGKTVYHSPGAPDIREFARDAIPDKDARGGEVFLLSGPTMMMPGHGHGHMEHSNWRMISLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELQFVGDECQVAGDPLMLRRALSNLLSNALRYTPPGEAIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSNARGTRFVIVLPERG
What is the function of this protein?
Member of the two-component regulatory system CusS/CusR involved in response to copper and silver.  Acts as a copper/silver ion sensor.  Activates CusR by phosphorylation.
What are the official names of this protein?
Sensor histidine kinase CusS.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SH_MUMPB
Sequence: MPAIQPPLYLTFLLLILLYRIITLYVWVVSTITYKTAVRHAALYQRSLFRWSFDHSL
What is the function of this protein?
Plays a role in the inhibition of the host NF-kappa-B pathway.  This inhibition occurs at the receptor level, by preventing the signaling of TNFR1 as well as IL-1R and TLR3.
What are the official names of this protein?
Small hydrophobic protein.
What is the protein family that this protein belongs to?
Belongs to the rubulavirus small hydrophobic protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: SPRE2_MOUSE
Sequence: MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTLHNEAELGDDDVFTTATDSSSNSSQKREPTTRTISSPTSCEHRKIYTLDPYPMDHYHPDQRLPRSYPQVTFPEDDEEIVRINPREKIWMTGYEDYRHAPVRGKYLDTTEDADSYVRFAKGEVPKHEYTYPYVDSSDFGFGEDPKGSVIKTQPPRAKSRRRKENGERSRCVYCRDMFNHEENRRGHCQDAPDAVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACHRCGVMCRCCGGKHKAAA
What is the function of this protein?
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:11493923).  Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (By similarity).  Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879).  Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668).
What are the official names of this protein?
Sprouty-related, EVH1 domain-containing protein 2, Spred-2.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules.
Protein: ATPD_POLNA
Sequence: MAELATIARPYADALYKAQGSDLATTALWVDKLAAVAGNAQLLQFADSPKVSVDQVFDVVAGVASNANDPLPEAARNFLRLVIENGRLSALPEIASQFRSLKNAAGGMTDAVVFSAFPMDEQALNDIAAVLEKRFGRKLGIKVELDPSLIGGIRAVVGDEVLDTSVKARLEQMKMALIA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RNP3_HALMA
Sequence: MYEAVYAHPDGDSTVARHALTAADSEYDGIVVRNHGDEQADYDADAISDAYGVDVAAGIEVRADDPSRASGFVGNYRSDRTVVVVHGGDRRINRFAVEQPTVDVLAHPMRDDGDFNHVLANAAADNGVRVEFDFGPVLRASGGSRVRAIKELRKLRELVENAGAPFVVSASPSTHLQIRAPRDIIAVGETIGFDADTVREGLTEWGQIVERNRERQSGAVIEPGVRLEDDADDAE
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 3, RNase P component 3, Rpp30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_SHESM
Sequence: MTKTERYLQLRSMIPEMRRIKRIHFVGIGGAGMGGIAEVLVNEGYVVSGSDIAQNAVTDRLCLLGAKIHIGHGADNVQQADVVVVSTAINPENPEIIAAKELRIPIVRRAEMLAELMRYRHGVAIAGTHGKTTTTSLIASLYGQAGRDPTFVIGGLLNSAGTNARLGTSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYGGDFEKLKSTFVDFLHNLPFYGVAVVCIDDAVVREIMPRIGRHMITYGFSDDADVQALNFQQQGHQCRFTVRRKGKEDLDLLLNLPGQHNVLNALAAIAVATEDEIDDSAIIQALAEFQGIGRRFQHLGKFATPKGEVMLVDDYGHHPSEVAATIKAARAGWPDKRLVMAYQPHRYTRTRDLYEDFIEVLSQVDCLLLLEVYSAGEAPIPGADGRALCRSIRLRGQLDPIFIASPDQLAEVLPDVLQEGDLLLTQGAGNIGALSRQLAASELGFSTAATTEVKP
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMND1_VIBCR
Sequence: MNTTIITDVECIITKPDRHNLITVIVHTNNGTVGYGCATFQQRPLAVKTMVDEYLKPLLIGKDANNIEDLWQMMMVNAYWRNGPVINNAVSGVDMALWDIKAKQAKMPLHQLFGGKSRDAIAVYTHATSDSMEGLYESIDNYLKQGYRHIRCQLGFYGGVPEALHTTQNPTVGSYYDQDQYVENTVTMFKLLREKYGNQFHILHDVHERLFPNQAVQFAKDVEKYKPYFIEDILPPNQTEWLDNIRSQTSVSLGLGELFNNPEEWKSLIINRRIDFIRCHVSQIGGITPALKLGHLCQTFGVRIAWHCPPDMTPIGAAVNTHLNVHLHNAAIQEHVEYKENTRKVFPGASEPKNGYLYASELSGIGVEIDTEVAADFPVTYRPHEWTQSRLPDGTIHTP
What is the function of this protein?
Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding.  May have evolved a divergent function.
What are the official names of this protein?
D-galactonate dehydratase family member VIC002985.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: CLPX_GEOMG
Sequence: MSRRNDSSENLTCSFCGKSQDEVKKLIAGPTVYICDECIELCNDIIAEESKLEEAMGPDVKKLPKPREIKDVLDEYVIGQDRAKKILAVAVYNHYKRIESMGKPSDVEMQKSNILLLGPTGSGKTLLAQTLARILRVPFAMADATNLTEAGYVGEDVENIILNLLQAADYDVERAQKGIIYIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTSNILFICGGAFAGLDNIIQQRIGVKTLGFGADVKSKVEKKAGELLTDVTPEDLLKFGFIPEFIGRLPVLATLHELDEAAMVQILKEPKSALVKQYQKLFEMEHVKLKFTDGSLVAIAREALKRKTGARGLRSILENAMLDIMYEIPSQTMVKEVVISEDVIYNREKPIIVYESVAESA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: LYRM1_RAT
Sequence: MTAASRQEVLGLYRSFFRLARKWQAASGQMEDTIKEKQYILNEARTLFQKNKNLTDPDLIKQCIDECTARIEIGLHYQIPYPRPIHLPPMGLTPRRGRGLQTQEKLRKFSKPLYLKSHDEVS
What is the function of this protein?
May promote cell proliferation and inhibition of apoptosis of preadipocytes.
What are the official names of this protein?
LYR motif-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family.
Protein: PHS_DICDI
Sequence: MAPTLLTEEQRKELIPKDWEMVVGRDAIKKTFTFKDFNQAFSFMTRVALVAEQMNHHPEWFNVYNRVEITLATHDCSGLSVNDTKMADIMNQFFNQLHQ
What is the function of this protein?
Involved in tetrahydrobiopterin biosynthesis.
What are the official names of this protein?
Pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RS4_BACAN
Sequence: MARYTGPAWKLSRRLGISLSGTGKELEKRPYAPGPHGPNQRKKLSEYGLQLQEKQKLRHMYGMTERQFRRTFDQAGKMPGKHGENFMILLEARLDNLVYRMGLARTRRAARQLVNHGHIMVDGARVDIPSYRVKPGQTISVREKSNNLVVVKEAIEVNNFVPEYLTFDADKLEATYTRHAERAELPAEINEALIVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PNP_BACSU
Sequence: MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLSTATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPLFADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQFIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAFQEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNAVVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGLLPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETGPMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLAMMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQMDIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKIRDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQLYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDKQGRVNLSRKAVLREEKEKEEQQS
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.  Necessary for competence development in Bacillus subtilis.  May be necessary for modification of the srfA transcript (stabilization or translation activation).  Involved in processing precursor type I toxin-antitoxin RNAs antitoxin SR4 and SR5 RNAs to their mature forms (PubMed:22229825, PubMed:26940229).
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase, Vegetative protein 15, VEG15.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y550_METVS
Sequence: MELFSEKISIKETNVLLKVDNPKLFKIAKKKIIDERLNLEKYISKNPVFLTTYSPFKISNDAPEIVKLMANSSENANVGPMAAVAGTFSELVIHSLLENNSKSAICENGGDIALSSDFDIIVGLYAGNSPISGNLGFKLKKEKIKNGYGVCTSSGTVGHSVSFGNADSVTVFAKSASIADAAATSIGNFAVGSPDEAINKCLEQAENILKIDGVFVTFQEYAGKVGKIPTLIRTEKKEAFGNVFEMV
What are the official names of this protein?
UPF0280 protein Mevan_0550.
What is the protein family that this protein belongs to?
Belongs to the UPF0280 family.
Protein: NUOA_RHOP5
Sequence: MADLIFPIAPGAALAIHVALSAGIVAAIIVVATIIREKRAGARPDVPYESGILPGTPPQGPQNAPYFLIAALFVIFDMEAAILFAWAVAARDAGWVGLIEAAIFIGVLLLALIYLWVDGALDWGGPRQRK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYL_STAA8
Sequence: MLNYNHNQIEKKWQDYWDENKTFKTNDNLGQKKFYALDMFPYPSGAGLHVGHPEGYTATDIISRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTKKNIQTFKRQIKELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVIDGVSERGGHPVYRKPMKQWVLKITEYADQLLADLDDLDWPESLKDMQRNWIGRSEGAKVSFDVDNTEGKVEVFTTRPDTIYGASFLVLSPEHALVNSITTDEYKEKVKAYQTEASKKSDLERTDLAKDKSGVFTGAYATNPLSGEKVQIWIADYVLSTYGTGAIMAVPAHDDRDYEFAKKFDLPIIEVIEGGNVEEAAYTGEGKHINSGELDGLENEAAITKAIQLLEQKGAGEKKVNYKLRDWLFSRQRYWGEPIPVIHWEDGTMTTVPEEELPLLLPETDEIKPSGTGESPLANIDSFVNVVDEKTGMKGRRETNTMPQWAGSCWYYLRYIDPKNENMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLYDLAIVPTKEPFQKLFNQGMILGEGNEKMSKSKGNVINPDDIVQSHGADTLRLYEMFMGPLDAAIAWSEKGLDGSRRFLDRVWRLMVNEDGTLSSKIVTTNNKSLDKVYNQTVKKVTEDFETLGFNTAISQLMVFINECYKVDEVYKPYIEGFVKMLAPIAPHIGEELWSKLGHEESITYQPWPTYDEALLVDDEVEIVVQVNGKLRAKIKIAKDTSKEEMQEIALSNDNVKASIEGKDIMKVIAVPQKLVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5HT1B_PIG
Sequence: VEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRAPDLPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLAMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMFNEDFKQAFHK
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various alkaloids and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling inhibits adenylate cyclase activity.  Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior.  Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B, Serotonin receptor 1B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYT_SALPB
Sequence: MPVITLPDGSQRHYDHPVSPMDVALDIGPGLAKATIAGRVNGELVDASDLIENDATLAIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVVDNGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHDARETFVKRGETYKVAILDENIAHDDKPGLYHHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGLMRVRGFTQDDAHIFCTEEQIRDEVNACIRMVYDMYSTFGFEKIVVKLSTRPDKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVVMNITDSQSEYVNELTQKLQNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVEAGKVAVRTRRGKDLGSLDVNDVIEKLQQEIRSRSLQQLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_RHIEC
Sequence: MPNLLLELRSEEIPARMQRKAAGDLKKLVTDALVEAGLSYEGAREYWTPRRLALDIHGLTARSADVREERKGPRTDANEKAIEGFLRGAGLSSISEAQVVNDPKKGDFYVAVISKPGRATEEIVAEVMPGIIRDFPWPKSMRWGKASSAPGALRWVRPLQSIVCTFGPEHEETTVIPFEIDGITASNITYGHRFHAPEAIMVRRFDDYAASLERAKVILDAERRKDIILHDARDIAFANGLELVEDEGLLEEVSGLVEWPQVLMGSFEEDYLSIPSEIIRLTIKTNQKCFVTRKQGEDTLSNRFILVSNIEASDGGKEIVHGNGKVVRARLSDALHFWKRDQGNLPDLETLAASAAKFGLDLQKPLDQRMAKLDALDVTFHAKLGTQGARVARIRALAQKLAAVTGADAALTDRAAVLAKADLRTEAVGEFPELQGLMGRKYAALQGENASVAAAIEDHYKPQGPSDRVPEDKVAITLALADKLDTLTGFWAIDEKPTGSKDPFALRRAALGVVRILLERGIRLPLLATTRDGDLLSFFHDRLKVYLRDQGARHDLIDAVLTPEADDLLMVARRVEALTAFITSEDGKNLLAGTKRATQLLAAEEKKGTVIADGVSPALFKLDAEKELFAAISSASKDAANAVAGEDFRSAMEALSKLRGPVDRFFEDVLVNDEDAAIRANRLALLRLIREATGTVADFSKISG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMC_MARMM
Sequence: MTPDGLYCDPAELDWSQPSGPRARAYGDVYFSAEDGLEEARAVFLRGCGLPEAWTGRRHYVVGELGFGTGLNALALWQLWRQTRPTDGWLDFVTVEKHPLDRDAAARAFAAWPELSDLASRLLTQWPSRLRGPQRLVFPEDGFAITIFQDEVEAALSQMTRPVDAWFLDGFAPDRNAAMWSQAVFNRLGELSVPGTRVGTFTVAGFVRRGLAEAGFDVAKRPGFGRKRERLEAVWPGEAVDGSLANVDGPVAVLGAGIAGASLVHALRRRGIETVLIDAHGVASGASGAPAGLLTPRLEKADRPHVRATLAAFDFARRLYDGRPGFHAEPVRRLPKDEREAERFAILADWMPDHLDWTGEALVMPGAGRFEPARLVADLVADAQCHRARIGRVEPLGSGIGLYDDAGECRFEVAHLVIAAGAGARRFYPDLQPSAGQLAVFDGAPPDMPTAWGNYACAAPGGVLVGATHDRGDQVGPEDVAEAGFRASVAERMPGLALGPVQGRWQGVRAATPDRLPVAGRLSERVSILAGLGSRGFAHAPLLAEDLASELMGGVPALAQTGREAMAPGRFAERRSRRAGQGAAG
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_NITEC
Sequence: MSVRHSGIGMTSPRTRVRMVERLREQGVRDEVVLAAMGSIPRHLFVEEALASRAYEDVALPINYGQTISSPWIVGRMSELLRNGGNNSLRKVLEIGTGCGYQTAVLAKIANEVYSIERIGPLLTRTRIRLRELGIRNIYLKHADGMRGLLEAGPFDGIMMTAVIPEIPETLLEQLAMGGRMVFPKGNRQQYLCVIDHTTEGFVETILDEVMFVPILPGTINR
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_YERPY
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLASTHGYQLTTIPEEADLLLLNTCSIREKAQEKVFSLLGQWKLLKEKNPQLIIGVGGCVASQEGEQLRQRAPCVDVIFGPQTLHRLPEMINHVQETNSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTFCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAYRGATYDGDICSFAELLRLVAAIDGIDRIRFTTSHPIEFTDDIIDVYRDTPELVSFLHLPVQSGSDRILTMMKRAHTALEYKAIIRKLRQARPDIQISSDFIVGFPGETQQDFEQTMKLVADIHFDTSYSFIYSPRPGTPAADLPDNVSEEEKKQRLHILQQRISQQAMEISRKMVGTVQRVLVEGTSRKNVMELAGRTENNRVVNFEGSPDMIGKFVDVEIVNVYASSLRGILLRTEDQMDLRTHESPQSVIARTRKENEIGVGIYQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2BA_PSEPO
Sequence: NLYQFKNMIQCANKGSRSWLDYVNYGCYCGWGGSGTPVDELDRCCQTHDNCYDQAGKKGCFPKLTLYSWKCTGNVPTCNSKSGCKDFVCACDAEAAKCFAKAPYKKENFKIDTKTRC
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 pseudexin A chain, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VP6_ROTRF
Sequence: MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLIKLSGIKFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEHIVQLRRVLTTATITLLPDAERFSFPRVITSADGATTWYFNPVILRPNNVEIEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPFEHHATVGLTLRIESAVCESVLADASETMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLVK
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices (PubMed:11285213).  This capsid constitutes the middle concentric layer of the viral mature particle (PubMed:11285213).  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes (By similarity).  VP6 is required for the transcription activity of the DLP (PubMed:12097594).
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid (PubMed:11285213). Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (Potential).