Protein: HPS1_DOTSN
Sequence: MKEQSQKIAIIGSACRFPGGATSPSKLWQQLVQPQDLLRPVPRDRFALSTYHNHDGTKPGATNVTNKAYLLDEDPMEFDASFFSISPAEAQGMDPQQRQLLEVTYEALESAGYGLSKVSGSSTGVYVGSSGADYRDIQNRDLDTLGRWHATGTASSILANRISHFYGLCGPSLTLDTACSSSLVGLHLAVQAIRNGDCEQALVAGSNLILDPTPYISGSRLKLFSPDAQCRMWDESGKGYGRGEGVAVVLLKPLVNALLDGDHVEAVIRETGVNQDGHTPGITMPSAEAQTNLIRHVYAKAGLDPRVTAPQFFEAHGTGTAAGDPVEARAIYESFFGDGKTVTNQAGAPKLNVGSIKTVIGHLEGAAGIAGLLKATLALQHAHIPPNLLFKKPNPALVPYLDALEVPVTAKQWPAVEEGTPRLASVNSFGFGGTNAHCLIESFPQDDSHPTGKRGLGRQESEETCIGPVVLSAQSGRSLMSAMKVLASYIESNPGARLRDLLHTLGRRRSKLSVRTFFVATSRQELISQLRHSAENVKDATGFGFRPPARLVGGSQGVLGIFTGQGAQWATMGRVLYQRCGQFRASIERCQAALDALPDGPQWSIAEEMLKTKQASRLSEAAVSQPLCTALQIALVDLIELAGLRFDAVVGHSSGEIAACYYMGLITSRDAICIAYYRGVHSSLAEGTNGQKGAMMAVSMTHNESNEFCSRPDFQGRIHIAAHNAPSSVTLSGDADAIFRAQKELAGAGIFARVLKVDTAYHSDQMLPCVAPYLQSLESLNIPIREPRSDCIWVSSVRPDSFDSSSSLNLEEMRSQYWLDNMVQPVLFAPAIAKALRQHGSSFDMAVEIGPHPALAAPAKDTIMEFSGTVPLYTGILERGLDDVHASSTAIALIWQQMTDDNIDVATYAEAFDVTGDPPAKLLKGLPSYEWDHKPYWRESRISRTIRRRENDSHPLLGSRLSADARNEFRWRNILRLVDVPWLSGHVFQDKTMLPLAAQVSMVIDACSLAFPQSSVESIDITDLEISRDILVEAEGPETELLSTLRVVDRNTTADGTTSISAAWSCHVSHDSELGIPESVCICQVQFSFGSGLAASLPRRVSDPSTTTPISSAKIYESFDHDGLQYSGLFNRLSSVSQALGFASASASWTCDELQDHKLHPAVLDVGFQLLMPATFSQKAENACGPYLPRSVACISLRRGFASLKTGEGLSLAIDAFSAVEESSNVLGDVAFYSASGECVIQVESVKLVPVITPDASNDRRIFTKDVWIEDTFDLSPYACDQDLEDDTGHLAGLVDRLCLYYCRQALDNMCGAVTLLSPLRLLHEELQAVIEAVKSGNHISLAAEYAEDSYDSLMEECLPYHDHKALKRVHELGQNLVKIMQGTTSSPRLRGARLDYPWNTELRNAIAILGHRITQKHPNMNILEIGNGDSGMTAHILQSIGTAYLSYTCASPRSMLSQSSPVDVLGNVELKSMNILQEPERQGFDRHKYDLLISSAPIHGDAAFQTALSNMRTLLRPGGYLLLVAKTGTNLLTTLTLGTSVVSGLESIEESNTPAGKSPSELDSLLLACEFSGLEQIVQDSPHVLTNAYSLIASHAASHMFNLVHNPRPSMAQIIDERARILLIGGRSLATARLVRDVRKMLSEVTPHIVFVDSIEKLEALPIEDDFDCLCFNDLDQPLFAGRRNAKTLEYLQKLYGNVRNLLWYTSGRIHKPEASMSIGVGRSLCGDAPWHNSQFIDVSSAAKVTAHSVVEAYCRLALAPTIASSNENLLWSVEPELVIQGDRTLISRVVENRSINDRFNATRRPILREAKYSEIEVCLKQDPQGQVQLAQYIPVQTIAHNAGLCRIRVKYTAALVAADAAKAALCFGHRVGTETPVFAITKQAGSLVVTPEAATLVCENETIDPVHNLSSMALYIQAAICASRAAQEGRTLLFGVREDVIGAVQTSPLWKDKPVIIVVIDSDDRQCADGVIFLHPMSTRRAIRKKLSQQIDMALDCSSFGHDQLWSRVISTLQCRHEKLTAVDFFAESSLSSLQGWLQEAHVAAPQMWHPQPEARAFDILPIQSIGQEGSSSQISSAIVAWQATENFTYRVAGLESEKLFSDSKTYFLAGMTDSLGLSISAWMIRSGAKHLVLAGRDPTIPPQWLEEMSSLGANIKVLTVDICQKVMLTKAVKEIQAHMPPIAGVCNATLVLSDGLLADETFESFDRTLKAKIDGSRNLDQVFSEPSLAFFVLFGSMVSVTGNSGQADYHAANLYMSSLVNHRRSRGLAASIMDTGVVTDVGLVQQGGDAVATMARRQYVEPISEATLHHWVGEAVLASPVSSGEESRIVVGPKRVPRTLDPDLRPAWYSNPRFSHFLIDDASPTSSDSQGSASLLERLQLAASEDHMLAILMEAAQAKLEALLGMEHGAVAAGGAGSLLSFGVDSGVALQASNWLAQEVHVRMPVMKLLTTPNLKQLCLDVMRNMATDLPRCSAKETAIGGTVMSVRAGRSASPGASCSDRSLSTRSDETRSIRTPALASSLQDSFVHTGASTPIDTLTSADSLHSATASGSAKGAPLSPGQAQLWAATIQSGNDTRYNFTLQFDVEGAIDVDRLRSALVSLIAQQEMLRCSFVEVSAGEVQQRVWPGKDLSRCFKHLPPGDLRRAEEEYERLSQHCWQLSEGDTFMLVLTNGPADKHVITLAAHHIIMDGMSIAMFFRLLALAYEGQHLPVLQRAYTAYAEEHVAELAADRLDDKLEFWKTCLSPLVPTMPVFPMAISGVRKALDDGDTGILTVKSSISAPVVDRIKSMGRKLRCTPFHFMTTALIVLCAKMLHLKDICIGVTDAGRLDERDGETVGHFADILPLRTRVEPGTSMADLVPIVLHNIAQAAENAGVPFSSIVRATKTPRSATHSPIFQVGFNFLPGDARTQFGASTMQWRTGNLAQSLNDVSWWVHARDDGSYTMQVDGRSDLYSLDGLDLLMQTYKDLAETLCTEPNTNLERLRTSSDQAIKAADEAGLGQAKDFGWETTLPDRFDAMAEKYFDQRAAVDSAGGVTYEELRHRVHDIAAALQDSGSAPGAAVAVITGPSVNTLASMLAIIRIRCVYVPLDLSLPHARHTAMIKDCGARVLLFEDSTAERASALRMDGMEVVNVFELLTVGRTQREVSNLSDPHEPAILLYTSGSTSVPKGVVLSQAGFLNYVAAKTAFLGLEREMVLQQSSISFDMGLAQMLHSFCNGGTLVIVPQHARGDPVATAQIMLAHHITFTVATPTEYTAWLSTSSHTIDQYDQWRHVCYGGEFVTDRLSAMFRQLQRQKPLLNNSYGPTETSCATTLCVMSEKGSPAMIGYVGKPLANSRIRIVDQDGQPLPLGHAGEICIGGPGLAVRYVNPDDTRNRFIMQQEVSSSSQASTQAPRRLYRTGDRGKLLVDGSLILLGRMEGDTQVKMHGLRIDVTEVEHALLNAIPDFLAEAIVTMRGAADNAFLVAHVVMSAGITASKGELQLLTRLLRLPRYMLPKSIIAVDGLPTTTSGKIDRRAISQLPLEAPGSKKTSADQLVEAEVLRIWREVLGEEAHLDSESDFFSVGGDSLLVIKLQAGIKALMGLSISLAELYETSTLREMAEKMASVRRTQPKPSLIDWDAEVQVPTPIAKLAAAARPDDHAESAATSGTEVVLTGAADLLGYEILVALLNEPSVRVIHCVAIAEGHGARLPSDARVVVYPGSLRHPTLSLSDEERSNLQDRAHAIIHAGAEGHCLNNYATLRSANLLSTQFLAQIALPRCLPVHFVSGTRVTLLSGTSSLPPLSVASYRPAQHGHDGYTATKWASEVFFEALTRLSPALPVTIHRPCALTGMNAAPDNVMNALVRCSAAIKAVPRNDEAEGYVDFKDARTVAHDMVEQVLAGLGHDPQRACSAGVRFIHHSSGHKVPARDLGRRMEMLYGGTFRKLEMGEWIALAKASAGLHYLAATFLEAMMDKHVTSVYPYMGEEI
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the hps1-dma1 gene cluster that probably mediates the biosynthesis a derivative of cyclopiazonic acid (CPA) (Probable).  The hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) nps1 might incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-terminal redox-incompetent reductase domain to make and release the tryptophan tetramic acid, cyclo-acetoacetyl-L-tryptophan (c-AATrp), as the first intermediate in the pathway (By similarity).  In addition, the cluster also includes the tryptophan dimethylallyltransferase dma1, the FAD-dependent oxidoreductase toxD, the cytochrome P450 monooxygenase cyp3. 1 and the methyltransferase DOTSEDRAFT_139328; the latter 2 being not present in all CPA-producing fungi but involved in additional modifications that occur in biosynthesis the of a range of CPA and CPA-like products (Probable).  Further studies are required to clarify whether the CPA-like hps1-dma1 cluster is functional or a non-functional relic reflecting evolution of D. septosporum (Probable).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.