PharMolix/UniProtQA huggingface dataset:
Protein: ILVC_SULSY
Sequence: MANIYYDEDASLDYLKDKTVAIIGYGSQGHAHALNLRDSGIKVIIGLLAGSRSIEKAKAEGFEVYSPDEAAKKADVIMILTPDTVQPALYQSAILPNLDEGNALAFAHGFNIHFGQIVPPSYVDVFLVAPKGPGHLVRWMYEEGKGVPGLFAVYQDFTGKAREIAMAYAKGIGATRAGLIETTFKEETETDLFGEQAVLCGGATALIKAGFETLIEAGYQPEVAYFECLHELKLIVDLIYQYGISGMRYSISDTARYGDVTRGKRVYEAVKPLYKKILEEIQEGEFAKEWILENVANRPHFNALVKKDEEHPVEKVGKELRKMMPWLGGRGL
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RL27_BART1
Sequence: MAHKKAGGSSRNGRDSESKRLGVKKFGGESVIAGNIIVRQRGTRWHPGDNVGIGKDHTLFALSEGKVSFQRKAGNRSYVSVIPMVEAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: AROE_XANC5
Sequence: MPVSRYAVFGHPVAHSLSPAIHTEFGKQTGIALDYTAIDAPLEDFSAALQRFADEGGKGANVTLPLKEAAYALASSLSDRARLAGAVNTLVRNDGQWQGDNTDGAGLVRDLTERQGLDLRGRRVLLLGAGGAARGVAPALLEAGITAMVVVNRSPERADALCDALGEPARVTSRYIEDLRELGDFELIVNATAAGRDRDAGAFALPLGLVNSLTAAVDLNYGDTAIAFLAWARAAQCRYAIDGLGMLVEQAAESFALWHGVRPDTDPVYAALRAREAVLVSAD
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: RS8_LISMO
Sequence: MVMTDPIADFLTRIRNANMVKHDKLELPASKIKKEIAEILKREGFIRDVEYIEDDNAGTIRVFLKYGATGERVITGLKRISKPGLRVYAKSTEVPKVLNGLGIAIVSTSQGVLTDKEARAKQVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RS17_BRUSU
Sequence: MPKRVLQGVVVSDKNDKTVVVKVERRYSHPLLQKTVRQSKKYKAHDENNQFKVGDFVSIQESAPISKDKRWVVLTSEAAG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RS2_BRUMB
Sequence: MALPDFSMRQLLEAGVHFGHQTHRWNPKMAPFIYGERNNIHILDLSQTVPLLNSALKVVSDTVARGGRVLFVGTKRQASDIIADAANRSAQYYVNARWLGGMMTNWKTISNSIQRLRKLDELLAGEAQGFTKKERLNLEREREKLDRALGGIKDMGSVPDLMFIIDTNKEAIAIQEAKRLGIPVVAVIDSNCDPDQIDYPIPGNDDAARAIALYCDLIARAALDGIARQQGAMGIDVGAQVEAPVEPALQAPAEGA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: ISPH_BACFN
Sequence: MVKVEIDEGSGFCFGVVTAIHKAEEELAKGVTLYCLGDIVHNSREVERLKEMGLITINHEEFKQLHNAKVLLRAHGEPPETYIIAKENNIEIIDATCPVVLRLQKRIKQEYMQEDLDEKQIVIYGKNGHAEVLGLVGQTTGKAIVIEKLDEARRLDFSKSIRLYSQTTKSLDEFWEIVEYIKEHISPDVTFEYYDTICRQVANRMPNLRKFAASHDLIFFVSGKKSSNGKMLFEECKKVNPNSHLIDSADEIDDSLLPGVNSIGVCGATSTPKWLMEEISEAIKAQIKRQ
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RPC2_MOUSE
Sequence: MDVLAEEFGSLTPEQLTAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIIKLAGNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVSTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIDFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLAKYNE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit.  Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.  Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.  Acts as nuclear and cytosolic DNA sensor involved in innate immune response.  Can sense non-self dsDNA that serves as template for transcription into dsRNA.  The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC2, RNA polymerase III subunit C2, C128, DNA-directed RNA polymerase III 127.6 kDa polypeptide, DNA-directed RNA polymerase III subunit B.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL1_STUS1
Sequence: MAKLTKRQKAIAEKIESGKQYAFEDAAKLLAEVSAVKFTESFDIAINLGVDPRKSDQVVRGATVLPNGTGKTVRVAVFTQGPGAEAALAAGADRVGMDDLAAEMKGGDLNYDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPDVATAVKNAKAGQVRFRTDKNGIIHTSVGKVGFDAAALKQNVEALLSDLKRLKPSTSKGIYVKRVTLSTTMGPGLVIDQASLEA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PA2B4_NAJNG
Sequence: NLYQFKNMIHCTVPSRPWWHFADYGCYCGRGGKGTPVDDLDRCCQVHDNCYEKAGKMGCWPYLTLYKYKCSQGKLTCSGGNSKCGAAVCNCDLVAANCFAGARYIDANYNINFKKRCQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows strong anticoagulant activity.  Binds directly with the coagulation factor FXa (F10) and blocks the formation of the prothombinase complex.  Acts by a nonenzymatic mechanism (PubMed:10462445).  Also inhibits the complex composed of tissue factor (F3) and coagulation factor VIIa (F7) (TF-VIIa complex) by both enzymatic and nonenzymatic mechanisms (PubMed:8866616).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 'basic', svPLA2, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 isozyme III/IV, CM-III/CM-IV.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EX7S_STRP7
Sequence: MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKELQATLDKAEKTLVKVMQEDGTESDFE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_SALG2
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAVRGMVNAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: SYC_PELTS
Sequence: MEIYNTLTRRKENFQPREPGRVCMYVCGPTTYNYIHLGNARPLVFFDTVRRYLIHKGYEVLFVQNFTDVDDKIINRAQEEGDDPLALARRYIGEYFKDADALNVRRADRHPLVSEHIPDIIKMVDELVKKGAAYVVDGNVYFEVRKFAGYGKLSGRTLEDMQAGARVEVDPRKRDPLDFALWKAAKPGEPCWDSPWGPGRPGWHIECSAMSLKYLGTNFDIHGGGYDLIFPHHENEIAQSEAATGQPFVRYWMHNGFITVNEEKMSKSLGNFFLVRDILAKFPPELVRFFLLSTHYRSPLDFDGEKMAAAGRGLERIKTSLRLLYEALERPVSEGVQAVCSRDPFDEIRASFEAAMDDDFNTALAIGAVFDLAREANTAVQRTGPAVSGQDRQILQYALDLFNEFNEVLGIFKVDGASGRLLIDGAAGDDSGLVEGLINLILEVRQEARKRKDWSTADRIRDGLKELGILLEDTPQGVRWKKQG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STHB_PHANO
Sequence: MMNPFFQNTSCSPYYRTDQPCSLGNYVSYAIPVAGVADIVAAINFTQTHNVRLVIKNTGHDYMGKSTGRGALSLWTHNLKSRQLVNYSSAHYTGPAIKVGAGVTGGEALVHASASGYRIVSGDCPTVGYSGGYSSGGGHSILNSVHGLAADNVLEWEVVTADGRHVVASPDQNSDLYWAMSGGGGGTFAVALSMTSRVHADSIIGAASLSFNATSAPSNDSFVSALNAWWAFLPSLVDVGATPSWNIFAGNFLVPNTTAPGRTAADMDTLYSPFLSELKRLGIPYAFESFSAPNYLQHYNDTDGPLPDGPLAAWA
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the phytotoxin stemphyloxin II (PubMed:31553484).  The first step of the pathway is the synthesis of dehydroprobetaenone I by the polyketide synthase sthA and the enoyl reductase sthE via condensation of one acetyl-CoA starter unit with 7 malonyl-CoA units and 5 methylations (PubMed:31553484).  The C-terminal reductase (R) domain of sthA catalyzes the reductive release of the polyketide chain (PubMed:31553484).  Because sthA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase sthE (PubMed:31553484).  The short-chain dehydrogenase/reductase sthC then catalyzes reduction of dehydroprobetaenone I to probetaenone I (PubMed:31553484).  The cytochrome P450 monooxygenase sthF catalyzes successive epoxidation, oxidation (resulting from epoxide opening) and hydroxylation to install a tertiary alcohol in the decaline ring to yield betaenone C from dehydroprobetaenone I and betaenone B from probetaenone I (PubMed:31553484).  The FAD-linked oxidoreductase sthB is responsible for the conversion of betaenone C to betaenone A via an intramolecular aldol reaction between C-1 and C-17 to form the bridged tricyclic system in betaenone A (PubMed:31553484).  Finally, the cytochrome P450 monooxygenase sthD catalyzes the hydroxylation of C-15 to afford the final metabolite stemphyloxin II (PubMed:31553484).
What are the official names of this protein?
FAD-linked oxidoreductase sthB, FAD-dependent BBE enzyme-like protein, Stemphyloxin II biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: DHPS_STRPN
Sequence: MSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMAYVVAEARAKVVIMFNPVMARPQHPSSLIFPHFGFGQTFTEKELADFETLPIEDLMVAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDLKQYK
What is the function of this protein?
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: GPAT3_ARATH
Sequence: MSAKISIFQALVFLFYRFILRRYRNSKPKYQNGPSSLLQSDLSRHTLIFNVEGALLKSDSLFPYFMLVAFEAGGVIRSFLLFILYPLISLMSHEMGVKVMVMVSFFGIKKEGFRAGRAVLPKYFLEDVGLEMFEVLKRGGKKIGVSDDLPQVMIEGFLRDYLEIDVVVGREMKVVGGYYLGIMEDKTKHDLVFDELVRKERLNTGRVIGITSFNTSLHRYLFSQFCQEIYFVKKSDKRSWQTLPRSQYPKPLIFHDGRLAIKPTLMNTLVLFMWGPFAAAAAAARLFVSLCIPYSLSIPILAFSGCRLTVTNDYVSSQKQKPSQRKGCLFVCNHRTLLDPLYVAFALRKKNIKTVTYSLSRVSEILAPIKTVRLTRDRVSDGQAMEKLLTEGDLVVCPEGTTCREPYLLRFSPLFTEVSDVIVPVAVTVHVTFFYGTTASGLKALDPLFFLLDPYPTYTIQFLDPVSGATCQDPDGKLKFEVANNVQSDIGKALDFECTSLTRKDKYLILAGNNGVVKKN
What is the function of this protein?
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.
What are the official names of this protein?
Probable glycerol-3-phosphate acyltransferase 3, AtGPAT3.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MON1A_HUMAN
Sequence: MHPGGGPSRAERLELGLGRERPAKAIFLHRRPGEGGGRERCLRCGHVCVRRGPGPREAVPSGRPRPDTLTPPWVRQRAVTGTFCASWTPLRNRRAQRMATDMQRKRSSECLDGTLTPSDGQSMERAESPTPGMAQGMEPGAGQEGAMFVHARSYEDLTESEDGAASGDSHKEGTRGPPPLPTDMRQISQDFSELSTQLTGVARDLQEEMLPGSSEDWLEPPGAVGRPATEPPREGTTEGDEEDATEAWRLHQKHVFVLSEAGKPVYSRYGSEEALSSTMGVMVALVSFLEADKNAIRSIHADGYKVVFVRRSPLVLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITDNLLQLMARDPSFLMGAARCLPLAAAVRDTVSASLQQARARSLVFSILLARNQLVALVRRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNAAGFFHAHISYLEPDTDLCLLLVSTDREDFFAVSDCRRRFQERLRKRGAHLALREALRTPYYSVAQVGIPDLRHFLYKSKSSGLFTSPEIEAPYTSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLAWVTGAFELYMCYSPLGTKASAVSAIHKLMRWIRKEEDRLFILTPLTY
What is the function of this protein?
Plays an important role in membrane trafficking through the secretory apparatus.  Not involved in endocytic trafficking to lysosomes (By similarity).  Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991).
What are the official names of this protein?
Vacuolar fusion protein MON1 homolog A.
What is the protein family that this protein belongs to?
Belongs to the MON1/SAND family.
Protein: RL15_AKKM8
Sequence: MLQLHTIKPNPGAKHRKKRLGNGESSGLGKTCGKGNKGQKARSGGTIRPGFEGGQMPLHRRLPKKGFNNTRFQDKILIVNLSQLERVFEAGATVDENTLRAAKLVQGPCDAVKLLGNGTLTKNLNVVVDFVSASAREKVTQAGGTVTVLSEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CYB_PERAP
Sequence: MTIMRKTHPLMKMVNHAFIDLPTPSNISGWWNFGSLLGLCLILQILTGLFLSMHYTPDTLTAFSSVAHICRDVNYGWLIRYMHANGASLFFICLYFHIGRGIYYGSYLYKETWNIGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSSLVEWIWGGFSVDKATLNRFFAFHFILPFIIAAMAMVHLLFLHETGSNNPLGIPSNSDKIPFHPYYSYKDLLGGAALLAFFFTIVLFFPDALGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVIALVLSILVLALFPLLHTSNQRGLMFRPISQTLFWILVSDLFILTWIGGQPVEPPFIIIGQVASILYFTIILILFPIAGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y391_HAEIN
Sequence: MDKNNKITPECQGLLDEINSPKYKAIFISGFYDLRMGGQPVPRFNAQASFIDNFKTRFVETVKLLAKSKSVYIFANNSSISRSPIRGYLLGKYGLEKYLEPIRRMGDIDASNKIIHDLVKDIPNVYWVDAQQYLPKDSVMAEGKYLYGDQDHLTNFGAYYMAKEFSKYQRVMTPEQVKKLYE
What are the official names of this protein?
Uncharacterized protein HI_0391.
Protein: P3IP1_BOVIN
Sequence: MLLAWVRTILVSNMLLAEAYGSGGCFWDNGHLYRADQPSPAPGHSCLNWLDAQSGLAFAPESGAGNHSYCRNPDQDPRGPWCYVSGEAGAPEKRPCQDLRCPDTTSQGLPTSATETEEAAEVPGGDEVFAPANALPARSEAAAVQPVIGISQRVRVNSKEKKDLGTLGYVLGITMMVIIVVIGAGIVLGYTYKRGKDLKAQHEQKVCERELQRITLPLSAFTNPTCEIVDEKTVVVHASQTPVDLQEGSAPLMGQAGTPGA
What is the function of this protein?
Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
What are the official names of this protein?
Phosphoinositide-3-kinase-interacting protein 1, Kringle domain-containing protein HGFL.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: UL145_HCMVM
Sequence: MYGVLAHYYSFISSPSVMVNFKHHNAVQLLCARTRDGTAGWERLTHHASYHANYGAYAVLMATSQRKSLVLHRYSAVTAVALQLMPVEMLRRLDQSDWVRGAWIVSETFPTSDPKGFWSDDDSPMGGSED
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by exploiting host DDB1-cullin RING ubiquitin ligases (CRLs)(PubMed:32075763, PubMed:35938868).  Mechanistically, recruits host DDB1 via a DCAF-like interaction motif to antagonize IFN signaling by STAT2 degradation (PubMed:32075763).
What are the official names of this protein?
Protein UL145.
Protein: UTP10_YARLI
Sequence: MSTLSQQLSQLGGGSTVDRTWKLKQHSKSLIYEPQVAQDQDFSFIHAVGVEGLRDLVSLDSRFAQFENNLFSDTSIDVDRYVQTQEQNDLLDKAISAFLSLIGPYLMLSPAVKALEWLVRRFHVNQMNAEQLLLCVLPYYDQDIYLRVADVIIKLPPLFVFLNKSKSAAQNPPRNLLIRAFSADMRLFELITEYIVGQTTTKTSYQRQLSFWSQFAIYGLVADKADPERMLEIYLPALAKLVVTIDTDCQIAAYMVLTVLGNKMPLNKEVFNALVETIAANWTQKAIKSGILCITQMYQQKQEPEVLPTSVMTALNKAGFQPSDVVALSQKYKMALFTLGYCMALLRNPDAANFKGLEEIISNTQFGSNESTFLMRYIVDWALAKETNTSVAALAAPVIAKWVTRGETVPELDQLELKLQTVFTEAAVEEMEVEEIQEDVDVESLVEQAKKAASQTTTYFSTKTSENYAELSKIFVQLIERGYTMDKFVSMFSSDIASLTFFARIWASPSPLLARLAAVEAAKTIITAAGEADFQNLIPYTCIALSDASQRVRKAAASFAEVLKSKQNKKPIWGVEKIYTNDCSYLGSGDVTVLLNALSLEECILDESFVIRQVSDMISKKKGYKSAFSTAVLAYLGSHAVSQEIIAIRTSLLTLVTSSEEPIVPTTKVVEPLYINPPNDLAYITELIRTVTDKTGIKFLESLIKNDSPIYDEVCDIVTQRLVKLWPTLKGDAHLGLFRFFVDLSLDKDVPFDSLDVLAHVDVPTKVFISLLDDCKVEQNTTSMDAPSDESTKRRRRSSSSTVRNLLQGKLHHIAERNLRKVSLVLELLVASKTTDDALLGPLFTQLGEILTLGTDSNLPIDYCQSLLADVLLNIIRANQHDGASIDRDIRVDIVVSAIRTASNAQIQNKYLLLVAELATVAPTLVLHSVMPIFTFMGANTLRQDDDFSVHVIEQTVARIVPCLAGNTDKVDMLLVSFVTAFPHIPQHRRVKLFGELVRALDASGTKDALATLLFLFAQKSAELKTARKTSEVSAIAKFCDSLFKLFDASKQLAVVLPYVTLVQELYAIIATDPKTKEKEKKTRRQIFLQVDKELEVSPIDFLVVLLESRILPLQAGLVQSPEALKIAENVLTVLIESQYPELLNVILSLLPLPLFVTVAGRLGSSVYKTVLARFSSGSIEEEDTKASDTLLESLHSLLKSTTDTGDLVLLLQIVETVASGFPKCSDALLVTCAGEAVAQLKNSDDDVFIQAVSVLSSLCLRLGARMIGLFPATISSVLARDSSDNLIALSVLALFATFIKRLPSFMVSSLPKIFEFALKCPADTDTRKQLFVVCVETMDSRVVLQTLCDSWKFVEGFENARLFADTLDLAVAEADKKQIHSKADSLITLCLEAFDSSLKLEANTAARVQNLFIKCLIAIVLKLNDKTFRPLFVKIVDWNTPERSTLLFKIVCRLQENLKSIVTSYYGYIIDLALEILNKASAITPALQRNILSSLYSSFRFDREEFWNNEERFTKISDALGAQFPYLTKVAPENSKLLIKAVVALCELASEDQKKQLNDMMIKLLRQAPLYGSRCFAALFNNVGEEFLPFLPQLVPQIAELLESEDEKVESAVRAELIPAVEEVLGESLDRYLA
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.  Involved in ribosome biosynthesis (By similarity).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 10.
What is the protein family that this protein belongs to?
Belongs to the HEATR1/UTP10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Membrane; Multi-pass membrane protein.
Protein: NACB_MAGO7
Sequence: MADVQERLKKLGASARIGYVLVNFFFSQASIGSRWKTGKGTPRRKMKRAPARSGGDDKKLQQTLKKLNVQPIQAIEEVNMFKSDGNVIHFAAPKVHAAVPANTFAIYGNGEDKELTELVPGILNQLGPDSLASLRKLAESYQNMQKADGDKEADDDDIPDLVAGENFEDKVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: RL18_BURCH
Sequence: MDKTQSRLRRARQTRIKIAELQVARLAVHRTNTHIYAQVFSPCGTKVLASASTLEAEVRAELADKSGKGGNVNAATLIGKRIAEKAKAAGIESVAFDRSGFRYHGRVKALAEAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: SYP_PSEPG
Sequence: MRTSQYLLATQKETPADAVVISHQLMLRAGMIRKLASGLYTWLPMGLRVMRKVEAVVREEMNAAGALEVLMPSIQPAELWQESGRWEQYGPELLRLKDRHQRDFCVGPTHEEVITDLARNELSSYKQLPLNMYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHADQASLQETYDRMHQAYSNVFTRLGLDFRPVQADTGSIGGSYSHEFHVLAESGEDDVIFSDSSDYAANIEKAEAIPRETVRPAPTEELRLVDTPDAKTIAQLVENHGLAIEKTVKTLIVRGAEEGKLVALVVRGDHELNEIKAAKLEQVADPLIMATDAELREAIGAGAGSLGPLNLPLEVVIDRSVALMSDFGIGANIDDKHYFGVNWERDLPVPQVADLRNVVEGDPSPDGQGTLVIKRGIEVGHIFQLGTKYSEALKCQVLGENGKPVVLSMGCYGIGVSRVVAAAIEQSYDDKGIIWNDALAPFQIALVPLRYETDVVREATDKLYAELTAAGFEVLLDDRDKKTSPGIKFADMELIGIPHRIVVSDRGLADGNLEYKHRTEQDAQALPLNEVLTFLQARVRR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.