PharMolix/UniProtQA huggingface dataset:
Protein: RL20_BURPS
Sequence: MPRVKRGVTARARHKKIINLAKGYRGRRNNVYRIAKQAVMRAGQYAYRDRRNKKRVFRALWITRINAAVRQHDMTYSVFINGLKKASIELDRKVLADMAVFDKAAFAAIVKQVKAAVAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CF410_HUMAN
Sequence: MKLTRKMVLTRAKASELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCGTSPHRYRMTVLRTLPRLQKLDNQAVTEEELSRALSEGEEITAAPEREGTGHGGPKLCCTLSSLSSAAETGRDPLDSEEEATSGAQDERGLKPPSRGQFPSLSARDASSSHRGRNVLTAILLLLRELDAEGLEAVQQTVGSRLQALRGEEVQEHAE
What is the function of this protein?
Plays a role in cilia formation and/or maintenance (By similarity).  Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987).  Involved in DNA damage repair (PubMed:26290490).
What are the official names of this protein?
Cilia- and flagella-associated protein 410, C21orf-HUMF09G8.5, Leucine-rich repeat-containing protein 76, YF5/A2.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, photoreceptor outer segment. Cytoplasm. Note=Colocalizes with NEK1 and SPATA7 at the basal body.
Protein: ABD12_MOUSE
Sequence: MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH
What is the function of this protein?
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:23297193, PubMed:25580854, PubMed:30420694).  Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (PubMed:23297193).  Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283).  Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:18096503).  Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167).
What are the official names of this protein?
Lysophosphatidylserine lipase ABHD12, 2-arachidonoylglycerol hydrolase ABHD12, Abhydrolase domain-containing protein 12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12.
What is the protein family that this protein belongs to?
Belongs to the serine esterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion.
Protein: GREA_NEIMB
Sequence: MQKIPLTVRGAELLKQELQQLKSVARPEVIEAIAEARSHGDLSENAEYEAAKERQGFIEGRISELEHKLSVAHIINPTEIHAEGKIVFGTTVTLEDLETEEHVIYQIVGEDEADIKQGKIYVGSPIARALIGKEEGDTAEVQAPGGVREYDIIEVRYI
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: PBG37_PLABA
Sequence: MKLYLVTFLFFVIYKNKTFVDCVTKKQDVYLDDEFKSFTFFFASSPSANFLSRIVHSNEAKFTQIKNKTDIWNKTIDKAYSINQVSNNIMRVYISLLSLFLFPYFSYIGIFGHSRNKANLTLSSLLAYFALLVSFFLFNGILNIGFVTSLPLVVAVLIFILGVSDCEINFLYKYTRYIFCFIISKLIYDVVTYISKDGANIFDYGFSGHIYMNLLRGKYYIVLKLIHLIILSLISLIIIKICPKIFSNNHLKSPISITFDKYIISFLCSLPIATAISQVFYLLSKTINPIDPSIFFMIPSSINFSSTGTIFSLSIWILMSYLMTFLRNKVEADFNNILNKIPNNLPDFI
What is the function of this protein?
Involved in the development of male gametocytes.
What are the official names of this protein?
Sexual stage-specific protein G37.
Protein: THN21_ARATH
Sequence: MKGRILILSLLIMSLVMAQVQVEAKICCPSNQARNGYSVCRIRFSKGRCMQVSGCQNSDTCPRGWVNAILENSADATNEHCKLGCETSVCGAMNTLQNSDASEIVNGASEQCAKGCSIFCTKSYVVPPGPPKLL
What is the function of this protein?
Seems to function as a defense factor.  Thionins are small plant proteins which are toxic to animal cells.  They seem to exert their toxic effect at the level of the cell membrane.  Their precise function is not known.
What are the official names of this protein?
Thionin-2.1.
What is the protein family that this protein belongs to?
Belongs to the plant thionin (TC 1.C.44) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS17_MARMM
Sequence: MPKRILQGVVVSDKGAKTIVVRVERTFLHPLLRKTVRRTKRYHAHDEANAYKVGDQVQIQECAPKSKLKRWEVVTVAA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: IBPB_ECOHS
Sequence: MRNFDLSPLMRQWIGFDKLANALQNAGESQSFPPYNIEKSDDNHYRITLALAGFRQEDLEIQLEGTRLSVKGTPEQPKEEKKWLHQGLMNQPFSLSFTLAENMEVSGATFVNGLLHIDLIRNEPEPIAAQRIAISERPALNS
What is the function of this protein?
Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpB, 16 kDa heat shock protein B.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESF1_RAT
Sequence: MSSKQEIMDDQRFRRVSKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTEDLKRFYDLSDSDSDLSDEESKVLDEKRVKEKKKQTKKETKSKTPIEEKKKETKKTDQKDSINKNDLNNSERIQKMKNSHKSPKIDSEVSPKDSEESLQSRKKKRDTTDLSVEASPKGKLRTKDPSTSAMVKSSTVSGSKAKREKQAVIMAKDNAGRMLHEEAPEEDSDSASELGRDEESEGEITSDDRASADDDENEDEEEEEDGEEEEEEEEEEDESDDESDSGPDLARGKGNVETSSEDEDDLADLFPEEPGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVVFSVKIYPSEFGKQRMKEEQIQGPVELLSIPEDAPEKDWASREKLRDYQFKRLKYYYAVVECDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDAASEVDLTAYKPKYFTSAAMGTSTVEITWDETDHERITTLNRKFKKDELLDMDFEAYLASSSEDEEEVEEAPEGEDGVSIEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKKKQKALAEEASEDEIPSDVDLNDPYFAEEVKKIGIKKKSMKSAKDGATSEEETELEKQKAEMALLVMDEEEDSKKHFNYDKIVEHQNLSKKKKKQLMKKKELLEDDFEVNVSDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARHREQKEERLIQAVERAQQDTGKPAQKQPMDPALSMLIKSVKNKTEQFQARKKQRIK
What is the function of this protein?
May constitute a novel regulatory system for basal transcription.  Negatively regulates ABT1.
What are the official names of this protein?
ESF1 homolog, ABT1-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ESF1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Is concomitantly relocalized into discrete nuclear bodies at higher expression.
Protein: MED29_DROME
Sequence: MNPNMNMMPMSGPQMMQVMQSSPSGPPGPVQHQQQQPPQPLQQQQQAEKLDNISRVKSLLGPLRESMFLTIRSSAFALQQNNLADNLKRDTGAHHVPRFDKHLEDFYACCDQIEIHLKTAMQCLQQQNSSNHYLPGPVTPMRMETFMPDNAGPISYPTYLNTVRVHIQSAKDIHDTLISAAQNISQAD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).  Required for female somatic sexual development.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 29, Mediator complex subunit 29, Protein intersex.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 29 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATP6_STAHJ
Sequence: MDHKNPLVSWNVFGFDLVFNLASIMMLVITAIIVFLIAIICTRNLKKRPSGKQNFIEWIFDFVRSIIESNMAWKKGGQFHFLAVTLILFIFVANMLGLPFAIVTKDHYLWWKSPTADATVTLTLSTMMILLTHYYGVKMRGTKAYIGNYFKPFWPLAIINVFEEFSSTLTLGLRLYGNIFAGELLLSLLAGLVVSSAWGWIIGIPGLIVWQGFSIFVGSIQAYIFIMLSMVYMSHKVADTH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MERB_PSEPU
Sequence: MDKTIYSKKIAESLSSGNHPEEFATLFVTLLRQLVMGRPVSREALGTALGWSGQRVATVLEPAPGTEYDEQGNIIGLGLTLRETPHVFEVDGRRLYTWCALDTLMFPALIGKTARVTSRCVATGRPITLTVAPEAVLQVEPAETMVSLLTPDASPDIRCSFCCHVHFFASPSVANAWASTHPGIELVPVENAFGLGHLIAHKLLEDSERNTA
What is the function of this protein?
Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate.  One product is Hg(2+), which is subsequently detoxified by the mercuric reductase.
What are the official names of this protein?
Alkylmercury lyase, Organomercurial lyase.
What is the protein family that this protein belongs to?
Belongs to the MerB family.
Protein: TI214_OLIPU
Sequence: MMVFQSFILGNLVSLCMKIINSVVVVGLYYGFLTTFSIGPSYLFLLRARVMDEGEEGTEKKVSATTGFIAGQLMMFISIYYAPLHLALGRPHTITVLALPYLLFHFFWNNHKHFFDYGSTTRNEMRNLRIQCVFLNNLIFQLFNHFILPSSMLARLVNIYMFRCNNKMLFVTSSFVGWLIGHILFMKWVGLVLVWIQQNNSIRSNVLIRSNKYKFLVSELRNSMARIFSILLFITCVYYLGRIPSPIFTKKLKGTSETGGTKQDQEVSTEEAPFPSLFSEEGEDLDKIDEMEEIRVNGKDKINKDDEFHVRTYYNYKTVSENLDGNKENSNLEFFKIKKKEDHFLWFEKPFVTLVFDYKRWNRPNRYIKNDKIENTVRNEMSQYFFYTCQSDGKERISFTYPPNLSTFFEMIQKRIPSFTREKTPSDQVSTYWSFIHEEKKENLKKAFLNRIEALDKEWSVENILEKTTRFCYNEAKKEYLPKIYDPFLHGVSRGKIKKLPPLQIITKTYRKNNIGRSWINKIHGLLLKINYHKFEQTIEKFNRKSLSIEKKLSFFSEPQQEEKIHSEEEIKVFKFLFDIVRTDSNDQTLIKNFSDFHEINKKVPRWSYKLISELEELEGENEENVPMEPGIRSRKAKRVVVFTDKEPHDEIYTNLKDNQNSDQKDEMALIRYSQQSDFRREIIKGSMRSQRRKTVIWDFFQAKVHSPLFFDRIDKLFFFSFDIWGLKKQILRNFMWKNKKKNFDKKEEEQSKIEEKRRIEIAETWDSFLFAQIIRGSLLVIQSILRKYIILPLLIIIKNSVRMLLFQFPEWSEDLKDWKREMHVKCTYNGVQLSETEFPRNWLTDGIQIKILFPFYLKPWHKSKFQASQKARLKKTTDKREKNDFCFLTVWGTETELPFGSAQKKPSFFEPIFKELKKRIKKLKTKSFLVLSIFKERATIFLKVAKEIKNWILKNFLFIKGKIKDLSKRNKIPVFDSREIYELNVNQTKKDSIISNQMINELSVQKKSMEWTNSSLSENKIKNLIDRIKTIRNQIEEISKEKQNLTNSCTKLRYDSKIIESSKKIWQTFKRKNTRLIRKSIFFIKFCIEQLSRAFFLGIINIPRTTIQLFFESTKTILDKYIYKNQENGEKKKKKNTIYFISTIKNLISKKKISYDLCSLSQAYVFYKLSQIKVSNFSKLKDVFEYNIRITSFFVKNQIKVFFQEQGIFHYELKNKTFLNSEVNQWKNWLRSHYQYNLPQIAWARLVTQNWKKKINKDSLVLNPSLTKEDSYEKKKFDNYKKQNFFEADALLNPKHNFKKDSIYNLFCYKSIHSTEKNLDMSIGIALDNCLVSSFLEKYNIRGIGEIRHRKYLDWRILNFWFTKKVNIEPWVDTKSKKKYINTKVQNYQRIDKITKTGLANQKRNFFDWMGMNEEILNHRITNFEFFFFPEFLLFSSTYKIKPWVIPIKLLLLNFTENINVSKNITRKKKGFIPSNEKKSLRFYNLTKEEKESAGQVELESDKEKKRNPESALLNQEKNIEENYAESTIKKRKNKKQYKSNSEAELDLFLTRYSRFQLRWNCFFNQKILNNVKVYCLLVRLKNPNEIAISSIERGEMSLDILMIEKNFTFAKLMKKGILIIEPIRLSVQNDGQLIIYRTIGISLVHKNKHKISKRYKKKSYIDKKKIEKSITKYQKKTVNRKKNNYDFFVPENILSPKRRREFRILICFNLKKKTVRDRNSRFDKNIQNWTTVLHKKKDLDKDKKNLINLKSFLWPNFKLKNLACMNRYWFNTTNGNHFSMIRIRMYTRFPIH
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: CAPSD_TTVV5
Sequence: MAWGWWRRWRRWPARRWRRRRRRRPLRRRRAGRPARRYRRRRTVRTRRRRWGRRRYRRGWRRRTYVRKGRHRKKKKRLILRQWQPATRRRCTITGYLPIVFCGHTKGNKNYALHSDDYTPQGQPFGGALSTTSFSLKVLFDQHQRGLNKWSFPNDQLDLARYRGCKFIFYRTKQTDWIGQYDISEPYKLDKYSCPNYHPGNLIKAKHKFLIPSYDTNPRGRQKIIVKIPPPDLFVDKWYTQEDLCSVNLVSLAVSAASFLHPFGSPQTDNPCYTFQVLKEFYYQAIGFSATDESRNYVFNVLYEENSYWESNITPFYVINVKKGSNTXDYMSPXISDSHFRNKVNTNYNWYTYNAKSHKNDLHXLRRAYFKQLTTEGPQQTSSEKGYASQWTTPTTDAYEYHLGMFSTIFLAPDRPVPRFPCAYQDVTYNPLMDKGVGNHVWFQYNTKADTQLIVTGGSCKAHIEDIPLWAAFYGYSDFIESELGPFVDAETVGLICVICPYTKPPMYNKTNPMMGYVFYDRNFGDGKWIDGRGKIEPYWQVRWRPEMLFQETVMADIVQTGPFSYKDELKNSTLVAKYKFYFTWGGNMMFQQTIKNPCKTDGRPTDSDRHPRGIQVADPEQMGPRWVFHSFDWRRGYLSEGAIKRLHEKPLDYESYFTQPKRPRIFPPTEAAEGEFREPEKGSYSEEERSQASAEEQATEETVLLLKRRLREQRKLEQQLQFLTREMFKTQAGLHINPMLLSQR
What is the function of this protein?
Self assemble to form an icosahedral capsid.
What are the official names of this protein?
Capsid protein.
What is the protein family that this protein belongs to?
Belongs to the anelloviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: PUR9_PROM0
Sequence: MSPLALVSVSDKKNIIPFCKELIEQFNYKILSSGGTAKHLIDAKIPVIKVADFTNSPEILGGRVKTLHPKIHGGILAKRTDEEHKKDVETNNLELIDLVVVNLYPFKKTVDQGAQWEDAIENIDIGGPSMIRSAAKNHKDVSVLVDPSQYQNFLEESKKGELKDAYKAKLALEAFQHTADYDTAISNWIRKERDLQSSKYIESYPLIKTLRYGENPHQKAFWYGLSNIGWNSAEQLQGKDLSYNNLLDLESALSTVLEFGYTEKDELKTDMFASVILKHNNPCGASISNSASKAFLNALECDSVSAFGGIVAFNSNVDSDTAVHLKDIFLECVVAPSFDEEALEILKVKKNLRILKFSKDQLPKKNQNSTKSIMGGLLVQDTDDSQEKTEDWISVTNKNANNQANLDLNFAWKICKHVKSNAIVIAKDQKTIGIGAGQMNRVGAAKIALKAAGSLCSDAVLASDGFFPFADTVELAHEYGIKAIIQPGGSLRDQESIDMCNLKGISMIFTQKRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: TOTA_DROYA
Sequence: MNSLTGFMCCALLLISPLCMGYTDEDREADSRKVAEIIRNSQDDDSKINSTQELLDIYRRLYPSLTLEDRESIDKFVNEHTDAILIDGVPSQGGRKTKYVGKVLSPAAKGFAIGFFEELGSKIAQLFTG
What is the function of this protein?
A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress.  Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response (By similarity).
What are the official names of this protein?
Protein Turandot A.
What is the protein family that this protein belongs to?
Belongs to the Turandot family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted from the fat body into the hemolymph.
Protein: CADM1_HUMAN
Sequence: MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
What is the function of this protein?
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:22438059, PubMed:12050160).  Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity).  Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).  In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536).  CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059).  By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity).  Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity).  Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).  Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity).  May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity).  May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity).  Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973).  May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246).
What are the official names of this protein?
Cell adhesion molecule 1, Immunoglobulin superfamily member 4, IgSF4, Nectin-like protein 2, NECL-2, Spermatogenic immunoglobulin superfamily, SgIgSF, Synaptic cell adhesion molecule, SynCAM, Tumor suppressor in lung cancer 1, TSLC-1.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Synapse. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder.
Protein: THIC_BURVG
Sequence: MNANPKFLSADAHVDAAAVAPLPNSRKVYVTGSQPDIRVPMREITQADTPTGFGGEKNPPIYVYDTSGPYTDPDAKIDIRAGLPALRQRWIEARGDTEVLDGLSSGYGRERAADPATADLRFPGLHRNPRRAQAGKNVTQMHYARQGIITPEMEYIAIRENQRRAEYLENLKASGPNGAKLAAMMGRQHPGQAFGAAAFGANALAEITPEFVRDEVARGRAIIPANINHPESEPMIIGRNFLVKINANIGNSAVTSSIGEEVDKMTWAIRWGGDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVRLQYVPLTANRMTGIVSRGGSIMAKWCLAHHKESFLYEHFEEICEIMKAYDVSFSLGDGLRPGSIYDANDEAQLGELKTLGELTQIAWKHDVQVMIEGPGHVPMQLIKENMDLQLDWCKEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVKEGIITYKLAAHAADLAKGHPGAQVRDNALSKARFEFRWEDQFNIGLDPDKAREFHDETLPKDSAKVAHFCSMCGPHFCSMKITQDVREFAAQQGVSETEALQKGMEVKAVEFVKTGAEIYHRQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: CCSA_TRIV2
Sequence: MNLVSLQNWLDNASFAVLFLTMLLYWIGAAFPGLPAINALGTAGMAIANLSIATLLGARWIEAGYFPLSNLYESLFFLSWGITTVHLIAENSSRSRLVGVFTTPVAMGIVAFATLTLPSDMQVSEPLVPALKSNWLMMHVSVMMLSYSALMVGSLLAIAFLVITRGNNIQLQGSSVGNGGYRTNGYRLMKAGELVSQPATPPVENNGFARLESQNNGNGNTAVLNLATTPQATTLTPTETLSPQRLSLAETLDNISYRIIGLGFPLLTIGIIAGAVWANEAWGSYWSWDPKETWALITWLVFAAYLHARITRGWQGRRPAILAASGFVVVWICYLGVNLLGKGLHSYGWFF
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: 14331_PSEMZ
Sequence: YEEMVEFMEKNLLSVAYKIISSIEQKEESRICEGILRLLDSHLIPSSTAAESKSAQDIAAAELAPTHPIRDSTLIMQLLR
What are the official names of this protein?
14-3-3-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: LISC2_ORYSI
Sequence: MAAYCSRVYHHHPVSPSTMQGSLARPSIHAGSASLTFRARPNSVSIVRCDADSPPEGSAVAGWAPPGPYTGRDPAARKPAWLRQRAAQGEKYARLRESLGELKLNTVCVEAQCPNIGECWNGGGGAGGDGDGIATATIMLLGDTCTRGCRFCAVKTSNKPPPPDALEPLRTAVAVASWGVDYVVLTSVDRDDLPDGGSGHFAQTVKALKELKPGILVECLTSDFRGDLEAVSSLASSGLDVFAHNIETVRSLQRIVRDPRAAYDQSLAVLKHAKNCKDGMVTKSSIMLGLGETDEEVKQTMCDLRAIDVDILTLGQYLQPTERHLRVREYVTPEKFDFWKEYGESLGFLYVASGPLVRSSYRAGELFVQNLVRRKKAELAPTLQ
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase 2, chloroplastic, Lipoate synthase 2, LS 2, Lip-syn 2, Lipoate synthase, plastidial 2, LIP1p 2, Lipoic acid synthase 2.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PUR9_ALKMQ
Sequence: MKRVLISVSNKEGIIPFARKLVHLGIEIISTGGTATLLREAEIDVMEVSELTGFPECLEGRVKTLHPVVHGGILADRSKDSHMKTLEELKIKPIDLVVINLYPFKETIQKKNVTLEEAIENIDIGGPTMLRAAAKNYRHVTVITNPEDYHAVLEEIEAKGNTEETTRYELAKKVFQHTSQYDTLIAGYLGKDELVFPEQLTVTYEKVQDLRYGENPHQKGAFYREIGCEEGTLASAKQLQGKELSFNNINDANGALALLKEFQEPTVVAVKHTNPCGVASAKNIDEAWDKAYAADPTSVFGGIIAANQVIDAETATKLLEVFLEVVIAPGYTPEALVLFKQKKNLRVLELSSILAEPKGQMDMKKVLGGLLIQEYNTGLIGNLKTVTEKEPTTEEIEDLLFAYKVVKHTKSNGIVVVRNQQTLAIGPGQTSRIWALENAIGNCIHPLEGSVLASDAFFPFKDCVEVGAKAGIKSIIQPGGSMRDQESIDACNERGMAMVFAGVRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: KELL_MOUSE
Sequence: MGPPWSQESSPEERLPTEWSRQLTRARWVLLAVLLCGLLLGSSMLWFYIFRNCGPCPCETPVCMELLDHYLASGNRSVAPCTDFFSFACEKANGTSDSFQALTEENKSRLWRLLEAPGSWHLGSGEEKAFQFYNSCMDTDAIEASGSGPLIQIIEELGGWNITGNWTSLDFNQNLRLLMSQYGHFPFFRAYLRPHPAPPHTPIIQIDQPEFDILLQQEQEQKVYAQILREYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDELQEMAPAIDWLSCLQAIFTPMSLNSSQTLVVHDLDYLRNMSQLVEEGLLNHRESIQSYMILGLVDTLSPALDTKFQEARRELIQELRKLKERPPLPAYPRWMKCVEQTGAFFEPTLAALFVREAFGPSIQSAAMELFAEIKDAVIIRLKKLSWISEETQKEALNKLAQLQVEMGAPKRAVKPDIATQEYNDIQLGPSFLQSFLSCVRSLRARNVQSFLQPFPYHRWQKSPWEVNAYYSISDHMVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCPACDTHVLQEALLCLERHYAAFPLPSISSFNGSHTLLENAADIGGVAIAFQAYSKRIVEHTGELTLPNLDLSPYQLFFRSYAQVMCRGLSSQDPQDPHSPPSLRVHGPLSNTPDFAKHFHCPRGTLLNPSARCKLW
What is the function of this protein?
Zinc endopeptidase with endothelin-3-converting enzyme activity.  Cleaves EDN1, EDN2 and EDN3 (By similarity).
What are the official names of this protein?
Kell blood group glycoprotein homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M13 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.