PharMolix/UniProtQA huggingface dataset:
Protein: CD3Z_PIG
Sequence: MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR
What is the function of this protein?
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.  CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme.  Plays an important role in intrathymic T-cell differentiation.  Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).
What are the official names of this protein?
T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain.
What is the protein family that this protein belongs to?
Belongs to the CD3Z/FCER1G family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: DAPB_BORBR
Sequence: MTQATPQRIAIAGASGRMGQMLIEAVLDTEGVELAVALDRAGSPSIGQDAGAALGRPCGVTITDQLDALAQADCLIDFTRPEGTLQHLQACLRHDVKMVIGTTGFDSSGRAEIEVAAQKIAIVFAPNMSVGVNATLKLLDMAARILNSGYDVEIFEAHHRNKVDAPSGTALIMGETVASAWDVALPDVATWTRHGDTGVRKPGTIGFSVVRGGDIVGDHTVFFCGTGERIEISHRSSSRATYAQGAVRAARFLARQDNGLYDMQAVLGL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_SHEAM
Sequence: MSNTLVLVLNCGSSSLKFAILDATNGDEKISGLAECFGLENARIKWKLRGEKHEASLGAFSAHREAVEYIVNKILVNEPELKGQLIAIGHRIVHGGEKFTHSVIIDDAVLKGIEDCASLAPLHNPAHLIGIRAAQASFPSLPQVAVFDTAFHQSMPDRAYIYALPYKLYREHGIRRYGMHGTSHLFVSREAAKALGKDVNDTNVICAHLGNGASVTAVKGGKSVDTSMGLTPLEGLVMGTRCGDLDPSIIYHLVHQLGYTLDEVNNLMNKQSGLLGISELTNDCRGIEEGYAEGHKGATLALEIFCYRLAKYIASYTVPLGRLDAIVFTGGIGENSDLIREKVLNLLEIFKFEVDSERNKAARFGNQGVITKEGSPIAMVIPTNEEWVIAEDSLRLVNK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_STRSV
Sequence: MSHNFTESYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEMLAFMPCNPSIGGSAKGIVVREVDALGGEMAKNIDKSYIQMKMLNTGKGPAVRALRAQADKELYSKEMRKTVENQENLTLRQTMINEILVEDGKVIGVKTATHQEYAAKAVIVTTGTALRGEIIIGDLKYSSGPNHSLAAIPLADNLRDLGFEIGRFKTGTPPRVKASSINYDVTEIQPGDEKANHFSYTSRDEDYVKDQVPCWLTYTNAESHEIIQNNLHRAPMFSGIVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRDTEEVYVQGLSTSLPEDVQKDLVHSIKGLENAEMMRTGYAIEYDMIMPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGINAALKIQGKQELILKRSDGYIGVMIDDLVTKGTVEPYRLLTSRAEYRLILRHDNADMRLTEMGREIGLVDDERWARFEIKKNQFDNEMKRLESIKLKPVKETNAKVEALGFKPLTDAVTAKEFMRRPEVSYQDVVQFIGPAAEELDEKIIELIETEIKYEGYISKALDQVEKMKRMEEKRIPANIDWDDIDSIATEARQKFKKINPETIGQASRISGVNPADISILMVYLEGKSRSISKNQAK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_DEHM1
Sequence: MNVSQVSNHIVVIKLGGSVLSSKDTSLKDIAALKQLGLKPVLIHGGASTVSDWSAKLGLETRLVNGERVTDDPTLDVVAAVLTGLVNKEIVAALLDMGVQAAGISGVDGATITGQMRATETGYLGDVTAVNTGLINALLDKDITPVISPVSFHHTKRPSGSRRLININGDPAAGEIAAALQAERLVFMTDVPAVKGKNGEALGEISAEHAAELLSSGTASGGMIPKLRSCLKATLAGASACIIDGRIPHMLVRELTEGNCGTTIIGQHLRRS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZORA_ECOLC
Sequence: MLAQLFEQLFQSIDSTLITNIFIWAVIFVFLSAWWCDKKNIHSKFREYAPTLMGALGILGTFIGIIIGLLNFNTESIDTSIPVLLGGLKTAFITSIVGMFFAILFNGMDAFFFANKRSALAENNPESVTPEHIYHELKEQNQTLTKLVSGINGDSEGSLIAQIKLLRTEISDSSQAQLANHTHFSNKLWEQLEQFADLMAKGATEQIIDALRQVIIDFNENLTEQFGENFKALDASVKKLVEWQGNYKTQIEQMSEQYQQSVESLVETKTAVAGIWEECKEIPLAMSELREVLQVNQHQISELSRHLETFVAIRDKATTVLPEIQNKMAEVGELLKSGAANVSASLEQTSQQILLNADSMRVALDEGTEGFRQSVTQTQQAFASMAHDVSNSSETLTSTLGETITEMKQSGEEFLKSLESHSKELHRNMEQNTTNVIDMFSKTGEKINHQLSSNADNMFDSIQTSFDKAGAGLTSQVRESIEKFALSINEQLHAFEQATEREMNREMQSLGNALLSISKGFVGNYEKLIKDYQIVMGQLQALISANKHRG
What is the function of this protein?
Component of antiviral defense system Zorya type II, composed of ZorA, ZorB and ZorE.  Expression of Zorya type II in E. coli (strain MG1655) confers resistance to phages SECphi7 and T7.  While most T7 infected Zorya-containing cells undergo abortive infection, a minority produce viable phage progeny.  These eventually accumulate to a high multiplicity of infection, leading to culture collapse by 170 minutes after initial infection (PubMed:29371424).  ZorA and ZorB probably assemble in the cell inner membrane and exert their effect there (Probable).
What are the official names of this protein?
Zorya protein ZorA.
What is the protein family that this protein belongs to?
Belongs to the MotA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNMA_MYCVP
Sequence: MRVLVAMSGGVDSSVAAARMVDAGHDVVGVHLALSSAPGTLRTGSRGCCSKEDAGDARRVADVLGIPFYVWDFADRFKEDVIDDFVESYARGETPNPCVRCNERIKFSALSARALALGFDALATGHYARLTDGRLRRAVDHDKDQSYVLAVLTAEQLRHAVFPIGDTPKPAIREEAARRGLAVADKADSHDICFIPSGDTRAFLGARIGVRRGSVVDATGAVLAEHDGVHGFTIGQRKGLGIPGPGPDGRPRYVTGIDAETGTVHVGDVTDLEVTSLLGEAPVFTSGVAPDAPVECAVQVRAHGGVVDAVAELRDGALEVSLRTPLRGVAPGQTLVLYRSDPDGDEVLGSATISAAR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GH109_SHEPA
Sequence: MKLNRRHFLKTAGLSAAGILTSQLPLSSAEAVPKKPAAGPSVMGLVVPKMDTVRVGFIGVGQRGSGHVKHFCHLDGVEIKAICDTDPQVLDESIQFVTTQGLPKPAQYTGSEQAYKDLLNRDDIDIVIISTPWEWHAPMAINTMESGKHAFVEVPLALTVDECWQIVDTAERTQKNCMMMENVNYGRDELMVLNMVRQGLFGELLHGEAAYIHELRWQMKEIDSKTGSWRTYWHTKRNGNLYPTHGLGPVSQYMNINRGDRFDYLTSMSSPALGRGLYAKREFPADHERNQLDYINGDINTSLIKTVKGRTIMVQHDTTTPRPYSRHNLIQGTNGVFAGFPNRIAIEQAGSDSYHKWDMDMAKWYAKYDHPLWLQMGQEAERNGGHGGMDFLMLWRMVYCLRNSEPLDQDVYDGTAWSVVNILSQESVNNRSNSVNFPDFTRGAWKTGKPLGIIGT
What is the function of this protein?
Glycosidase.
What are the official names of this protein?
Glycosyl hydrolase family 109 protein.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.
Protein: SEC11_YARLI
Sequence: MVNFGAQSIRQTLVQLLGFAAIFTSSYMFYKGLSIVANSESPLVVVLSGSMEPAYQRGDVLLLWNRQKHVDVGEVVVYNIDGRTTPIVHRVLRSHASDNKQLLLTKGDNNAVDDVSFYGGRNQYLDREKEVVGVVKGYLPLVGYITILLAENQYFKYGLLGITGLLAFIQGE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: CYSZ_ECOSE
Sequence: MVSSFTSAPRSGFYYFAQGWKLVSQPGIRRFVILPLLVNILLMGGAFWWLFTQLDVWIPTLMSYVPDWLQWLSYLLWPLAVISVLLVFGYFFSTIANWIAAPFNGLLAEQLEARLTGATPPDTGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYLIPGIGQTVAPVLWFLFSAWMLAIQYCDYPFDNHKVPFKEMRTALRTRKITNMQFGALTSLFTMIPLLNLFIMPVAVCGATAMWVDCYRDKHAMWR
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL16_STRGG
Sequence: MLIPRRVKHRKQHHPKRSGMSKGGTQVAFGEYGIQALTPAYVTNRQIESARIAMTRHIKRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWIANVKPGRVMFELSYPNEKIAREALTRAAHKLPMKCRIVRREAGES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MMS22_YEAST
Sequence: MDVDEPNPIVISDSEATDEEISIIYEPEFNENYLWAEENVQEASRSQKIVTERLSLDSTAGESCTPSVVTDTQVTTGLRWSLRKRKAIQKMPYSLERIKHRQLLEGYDISSFDSISNQLTLPKNASTVIHSNDILLTKRTGKPLDEQKDVTIDSIKPENSSVQSQRYDSDEEIPKKRHRTFKDLDQDIVFQSGDSTEDEQDLASTNLQNTQNDEVIFRGRVLNVRTGYRGVLPRVAWEKSLQKQQSSKVTKRKTQLLNHKGVAKRKMNRSAHIEDEEQNLLNDLIAPDDELDIEENAPPDIYLGNLPEDREANEKELKELQEYYESKYSEDAQSAGTSGFNLNEEYRNEPVYELEYDGPGSCISHVSYKDQPIIYLNSRHSDSGFSEQYNISAEDNQSVISLDAAEEHNDGIIDKMLVKPKRIKATNDANFLNTKSKRVRRYKYKYRNSCLAPSTKAIKVGKRSAHKSHLAANNPVSFVSKKNHVIDDYFFEELESQSLEQDDSSSLKPQKKRRKKKAPIYSSFSADLESRRKPVFNTVVEVPTNRYAFTKPNVRNRDSINHDMEFEEEDSNQELGPIMVVLDSILLKKPFEPPNFFKIQLSDKSFLLSKLNPADIATSLQKIFRVIIDKGITDTELVHFNESLIAFLVHLDMPELFDLIGEFHREFRSKVNSLRKKAKPIHFFQIAACQLMFLEISRYNKISAAAKFDMDVKLLDHIVSFFKLLSVCYDSVMKNPMQYLYTSYYILSAVVDVIHKKEALWDLFQKHPFSPHISLLLVNIFPTKVCRWQVLRLDSEFQPLSSAFRFINYCIETCNWNVTNSLILSLDRIFKRRRFSDFEEESDLSQNNKIIYPPTNQLTSRLMFNRYLHLLTLCELSSSDTQRVIPMGDISMNDSLSVLKNRLNLLIVLATRFDLNLEKRFQELTRPLYSKEYLNLHTQNTVRTITTLIMQASLSFLEISRIKNHPFSGKFIASLFDKLVLQQPSISGVTENFLKEFTNLVSKMKRKSVSMLKFLYPSLVAMSQENIFESSFFLLLQVYLKSLDVLGPTWVQNYLFQFIKSKAQENERWIECYCQIGKFLVDSGIFTWWTFFTYNGLDAALHFQLAFHSLIIDFCDTDSFELLKKPLYSIASDLLLISKDDAFYHFLSNLLKRAHIIVADLKPVSDENELLRLAYIFSKALKKNAYQDLLAVFLSLAKKHYDEGDISRNFLAKYLEFLNKNCLTELRNNQLFISLRRELGISSDEDEKCAFWDSFNEAGDILSKAAFVETGIVQACCTGNEIDGYLDNLSTLFTSTMLESPFAFFSDLVIAHIFENRPFFDVNIKNFLLSHFIDLFNKVLKMKFEQVSPDEFAELCKVYRALCIECATDDTFNSNSDLIAAKDAFLVSVLRIADGFWEHDKLLQLRMLDSNMNIPNQIPHTTLQSSLSAIVIKIIESNIGKIEASEPFKTFKNT
What is the function of this protein?
Substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-MMS22).  RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks.  RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125.  Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition.
What are the official names of this protein?
E3 ubiquitin-protein ligase substrate receptor MMS22, Methyl methanesulfonate-sensitivity protein 22, Synthetically lethal with MCM10 protein 2.
What is the protein family that this protein belongs to?
Belongs to the MMS22 family.
What are the subcellular locations of this protein?
Nucleus. Note=Nuclear punctate foci structures.
Protein: NLE1_YEAST
Sequence: MSTLIPPPSKKQKKEAQLPREVAIIPKDLPNVSIKFQALDTGDNVGGALRVPGAISEKQLEELLNQLNGTSDDPVPYTFSCTIQGKKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWTH
What is the function of this protein?
Involved in ribosome biogenesis.  Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits.  Interacts with the AAA-ATPase Midasin (MDN1/REA1), which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.
What are the official names of this protein?
Ribosome assembly protein 4, Notchless protein homolog 1, Ribosome biogenesis factor RSA4.
What is the protein family that this protein belongs to?
Belongs to the NLE1/RSA4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: Y124_PROMP
Sequence: MYSLEISLRYSPFPLSIQKKEYEDIKRIYDEIKDSMNSDNQNSPLIELSCEKVQDKLITVLAKEVISVQIYEKSAVAGGSKRPGFSLDI
What are the official names of this protein?
UPF0367 protein PMM0124.
What is the protein family that this protein belongs to?
Belongs to the UPF0367 family.
Protein: SYT_STAES
Sequence: MNQINIQFPDGNTKEFDKGTTTEDIAQSISPGLRKKAVAGKFNGQLVDLTRPLEQDGAIEIITPGSEEALEVLRHSTAHLMAQALKRLYGDVKFGVGPVIEGGFYYDFDMDDKVSSDDFDKIEKTMKQIVNENHKIVREVVSKEKAKDFFKDDPYKLELIDAIPEDESVTLYTQGEFTDLCRGVHVPSTSKIKEFKLLSTAGAYWRGNSDNKMLQRIYGTAFFDKKDLKAHLKMLEERRERDHRKIGKDLELFTNNQLVGAGLPLWLPNGATIRREIERYIVDKEVSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMFPAMKLDEDEAMVLRPMNCPHHMMIYKNKPHSYRELPIRIAELGTMHRYEASGAVSGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIQDVYKDFGFEDYRFRLSYRDPEDKHKYFDDDEMWEKAESMLKEASDELGLTYEEAIGEAAFYGPKLDVQVKTAMGKEETLSTAQLDFLLPERFDLTYIGQDGEQHRPVVIHRGVVSTMERFVAFLTEETKGAFPTWLAPMQVEIIPVNIDLHYDYARLLQDELKSQGVRVEIDDRNEKMGYKIREAQMKKIPYQIVVGDQEVEHQEVNVRKYGSEKQESVEKDEFIWNVIDEIRLKKHR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR835_MIMIV
Sequence: MYYASTCMDHEIVEKKYKLGLNVTDNYKVRYNISLISQIFEGRCDYKNVVRLSLPKSLDLYKTGSNHYAYTLEVNMINVEKIYKLDNFEDVKELIDLGADINEAIKNIIIVNNIDSLKYLLEKGANIDLIDSYLAKMGNIDIFEFLFVKKCPMNKFLPIAVEYGHLNLVKFLVEKGVYVDFIDRTKYTFSEYTPLVAACSAGHIKIVEYLIEKGANYKSSYGVYLAAEKGHYDIVKFLIDKGTDLEKYGLRSLNEVIKKGHFDIMKLFINSGLEIDYDYYIYKAGLRGHTDIVKYLVMMQMSKQIQKI
What are the official names of this protein?
Putative ankyrin repeat protein R835.
Protein: DDL_TREDE
Sequence: MNIAIIYGGKSSEHEVSLQSASSIIRTIDKKHKLHLIGISKNGAWYLHGDEERERIIKNEKAVLKIKKDEAKRVTVIPGGGAKKGLKAGDEFLPTDAVFAVLHGRFGEDGTIQGLFEMADLPYVGGDVMSTSISMDKEKTKMIWDYSGLPIVPYIAIKRQDWDDPEKKKAILARAEKDLEYPLFIKPCRAGSSVGAGMVKNRNELLEQAEESFLWDNKILVEACIEAREVECSVTGNTKTVAYIPGEIIPTHKFYDYEAKYTDPNGAELKIPADLNETQRKTIRETAIKAYEALDLSGLSRVDFFIDKRTGKIYLNEVNTIPGFTAISMFPKMCGASGLPYNELIMHLIELAIDRFKTDRKLKTCRQS
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOC_UREP2
Sequence: MNKYNIYVDHTLLKADASLEEIHKLCEEAEENEFYSVCINPCFVKVAKHYLLETSVKICTVIGFPLGANTIETKVFETKNAIDLGADEIDMVININQLINGNREYCLNEINQIKEVCGDKILKVIVETAFLNREQKEFAAKIILESNADFIKTSTGFAKEGAKLEDIILWKRILGDVKQIKASGGIKNFEDFKSFIEAGATRIGTSSAIKILNNH
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_ENT38
Sequence: MGQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEKPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: FUB12_FUSO4
Sequence: MPLPSRASSTPKISKACVPCRTRKIKCNAAVVGLPCGSCVSRECPDDCVLSARKRRTVKVRNAEAPRSRKNIPDTNGSVLSPRQQQLPTNVSRQTTDSSHSDPVEESIHASHTGSSLRNDTPHSRDRRPPGQAQADLLYLNILQDTVNDTSAAQTDASDHQSNDEPDDSFNSQIHHWNPPPQLDDVDNEYLAKKKVFELPPPRFMDDIVKAYFDYVHPFAPILNRTDFIQSYRLGTCCLFLLHAVAAAASLYVTHDVLLGCGYPDRSTAQASFFSKAKLFHDFHCQGDPLSMLQGSMILGAIILDHPSDRDFQYWFHNSVRRASKMGVQNACLRDDGSQKLYRRIWWVLHNRDIFHFFINTQNMRLLANAPPIRPLTEADWETEDIEQWSGILSPISQAQKVSLIAQCELAQIFGNVMSVVTSSTPSAEEIHKRILPLDAWRTSLPDRMQLMASFADGEIYHLEALTTSYRFECIMCRLLRRGRWQMSDGGLREWAQQRFRSAIFELDTIVKRVMINNTIQKLPTTFITTITALLALHIESALDAAESSLIRSMARISVQHTMLALDQIRDTPAIKRALPAFEIVLSKNKLYPTSSSDTEQINTMQAISQDQTLNDGHILQPAQADMTLPQDDQSFLYGDFIGFDFLDRWQMEQLDFTGIY
What is the function of this protein?
Efflux pump involved in export of biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:25372119).  Constitutes a self-protecting mechanism of the fungus against critical levels of FSA within the cell (By similarity).
What are the official names of this protein?
Fusaric acid cluster transcription factor FUB12, Fusaric acid biosynthesis protein 12.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMA_MYCA9
Sequence: MKILAAMSGGVDSSVAAARMVDAGHEVVGVHLALSAAPGTLRTGSRGCCSKEDAADARRVADMLGIPFYVWDFADRFKEDVIDDFVEAYAEGRTPNPCVKCNEKIKFAALADRAVALGFDAVATGHYARLQDGRLRRAVDADKDQSYVLGVLTPEQLRRAMFPVGDSPKPDIRAEAEQRGLLVANKPDSHDICFIPSGDTQAFLGARIGVRRGNVVDADGSVLATHAGVHEFTIGQRKGLGLVGPAADGRPRYVTSIDAETATVRVGTVEDLEIWEFGGEPVVWTSGRVPGQPIECQVQVRAHGSVVDAIVEPGAERIHVRLRTALRGVAPGQTVVLYRPDAEGDEVLGSAVITRD
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_SALPA
Sequence: MEIYAVFGNPIAHSKSPFIHQQFAQQLDIVHPYGRVLAPINNFINTLDAFFAAGGKGANITVPFKEEAFARSDELTERASLAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLNFIRPGLRILLIGAGGASRGVLLPLLSLDCAVTITNRTASRAEALAKIFAHTGSVHATDMDKLDGCEFDLIINATSSGIRGEIPAIPASLIHPSLCCYDMFYQKGNTPFLSWCVQQGAKRYADGLGMLVGQAAHAVLLWHGVLPQVEPVIELLQQELLA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: SSRP_STAAN
Sequence: MAKKKSPGTLAENRKARHDYNIEDTIEAGIVLQGTEIKSIRRGSANLKDSYAQVKNGEMYLNNMHIAPYEEGNRFNHDPLRSRKLLLHKREIFKLGEQTREIGYSIVPLKLYLKHGHCKVLLGVARGKKKYDKRQALKEKAVKRDVARDMKARY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: LEPA_THEVB
Sequence: MTDVPVSHIRNFSIIAHIDHGKSTLADRLLQLTGTVDPREMKEQFLDNMELERERGITIKLQAARMTYTSRDGETYILNLIDTPGHVDFSYEVSRSLAACEGALLVVDASQGVEAQTLANVYLALEHNLEIIPVLNKIDLPGAEPDRVKAEIEEIIGLDCSQAVLASAKEGIGIEEILESIVHLVPPPRDTVDQPLRALIFDSYYDAYRGVIVYFRVMDGIVRRGDRIRLMASGKEYEIDELGVLAPNQKPVESLHAGEVGYLAAAIKAVGDARVGDTITLAHNPAKEPLPGYTEAKPMVFCGLFPTDADQFEDLREALEKLKLNDASLHYEPETSSAMGFGFRCGFLGLLHMEIIQERLEREYNLDLIITAPSVVYRVTTVKGEVLMIDNPSLLPEPQYREKIEEPYVQLEMITPETYVGTLMELAQSRRGIFKDMRYLTQGRTTLVYEMPLAEIVTDFFDEMKSRSRGYASMEYHLIGYRANDLVKLDILINNDPVDSLAAIVHRDKAYHVGRALVSKLKDLIPRHQFKIPIQAAIGSRVIASESIPALRKDVLAKCYGGDVTRKRKLLEKQKAGKKRMKAIGRVDVPQEAFMAVLRLKNE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL20_ACIBS
Sequence: MARVKRGVVAHRRHKKILARTKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQKKRQFRALWIARINAGARQNGLSYSRMIDGLKKAQVIIDRRVLADIAMHDAVAFAALAEKAKGALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.