PharMolix/UniProtQA huggingface dataset:
Protein: RF1_BORAP
Sequence: MFLEKLNSATSRIKSIEEKLQDINLIKNQKKYSKIIKEYTYLEKINTKKIEYENILNQINDNKTILEKEEQQEMKELIKQELIDLDKKKENLEHEIKILLLPQDENDSKNIIIEIRAGTGGEEAALFANNLYSMYIKYSEKKKWKTEIINFNETELGGFKEIIFEIKGKDVFKKLKYESGVHRVQRIPITESNGRLQTSAATVAVLPNIEETEIDINEKDLRIDVYRSSGAGGQHVNTTDSAVRITHLPTGIVVQCQNERSQHKNKDQAMKILRARLYEFEDSKKQEQRSNNRKQQVGSGDRSERIRTYNFPQNRITDHRANITLYKLEEFMQGELDQLLDPLTIELQEQTLKSNNI
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_STAAS
Sequence: MLDNKDIATPSRTRALLDKYGFNFKKSLGQNFLIDVNIINNIIDASDIDAQTGVIEIGPGMGSLTEQLARHAKRVLAFEIDQRLIPVLNDTLSPYDNVTVINEDILKANIKEAVENHLQDCEKIMVVANLPYYITTPILLNLMQQDIPIDGYVVMMQKEVGERLNAEVGSKAYGSLSIVVQYYTETSKVLTVPKSVFMPPPNVDSIVVKLMQRTEPLVTVDNEEAFFKLAKAAFAQRRKTINNNYQNYFKDGKQHKEVILQWLEQAGIDPRRRGETLSIQDFAKLYEEKKKFPQLEN
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOAH_ECOUT
Sequence: MFAGLPSLTHEQQQKAVERIQELMAQGMSSGQAIALVAEELRANHSGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: PGRP1_BOVIN
Sequence: MSRRYTPLAWVLLALLGLGAAQDCGSIVSRGKWGALASKCSQRLRQPVRYVVVSHTAGSVCNTPASCQRQAQNVQYYHVRERGWCDVGYNFLIGEDGLVYEGRGWNTLGAHSGPTWNPIAIGISFMGNYMHRVPPASALRAAQSLLACGAARGYLTPNYEVKGHRDVQQTLSPGDELYKIIQQWPHYRRV
What is the function of this protein?
Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.  Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:11880375, PubMed:16394004).  Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane.  In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement.  Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system.  Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity.  Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (By similarity).
What are the official names of this protein?
Peptidoglycan recognition protein 1, Oligosaccharide-binding protein, OBP, Peptidoglycan recognition protein short, PGRP-S.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule.
Protein: NF7O_XENLA
Sequence: MEEDEGADDGEQEEEEVLLVNVGSTYPCKRSDGSQHDADIVKTRYNKQAGREEYYVHYVGLNRRQNEWVDKSRLVLTKPPKEVETNGTDQEEMTEPTEQPDSKTPQKRKLEEPEPEPKKAKVEDKDASKTAASLGAAGDFAEELTCPLCVELFKDPVMVACGHNFCRSCIDKVWEGQSSFACPECKESITDRKYTINRVLANLAKKAACTPVTPVEKKTRPLEKCSEHDERLKLYCKDDGTLGCVICRDSLKHASHNFLPILDAIGVYREELSAIVAPLEASLKVTEQLSGEQSDKIEQHNKNVSQYKEHVTSEFEKLHKFLKEREEKLLEQLKEQGDNLLTEMENNLVKMQENQDAIKKTISLAKERMEETDSISFLTDIKTFIDKCQEQQRAVISTGNTLLSKELCQGTFKGPIQYIMWKELKSVITPSLTPMLLDPNSAHPNLHLSDGLTSVRYGENKLSLPDNPKRFSQCILVLGSQGFDSGRHYWEVEVGDKTAWDVGMASESSNRKGKIKLNPKNGYWAIWLRNGNRYKALESPSKALSLTSHPRKIGVYVDYEGGQISFYNADNMTIIYTFSATFTEKLYPYLSPFLHDSGKNVDALRFVHNQ
What is the function of this protein?
Transcription factor that determines dorsal-ventral body axis.
What are the official names of this protein?
Nuclear factor 7, ovary, xNF7-O.
What are the subcellular locations of this protein?
Nucleus.
Protein: TDCC_ECOUT
Sequence: MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEKDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THII_THEKO
Sequence: MFNVVIVRYGEIGTKSRQTRRWFENILMNNIREALVSEGIDFKKVEAKHGRVLVRTNRAREATEVLTRVFGIVSLSPAMEVDAELEKINKTALKLFRKKKRELNLEKPKFRVTARRITKEFPLKSPEIQAKVGEYILENEESEVNLHEYDIEVGVELMEGKAYIFVDKIRAWGGLPIGTQGKVVALLSGGIDSPVAAFLMMKRGVEVIPVHIYMGEKTLEKVRKIWNQLKKYHYGGKAELIVVKPQNREEMLKKIKELGKEKYTCVLCKFMMVKHADRIAKEFGAKGIVMGDSLGQVASQTLENMYIVSQASDLPIYRPLIGLDKEEIVDIAKKIGTFELSTLPEDEIPFIPKHPVIRGSWEEFRKIYMAIFGEEPRKRDC
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPF_NOSP7
Sequence: MAIEFTKYHGLGNDFILIDNRSSSLPVLTPEQAIQLCDRHFGIGADGVIFALPGENGTDYTMRIFNSDGSEPEMCGNGIRCLAGFLADLEGQSRNKDSYRIHTLGGVMTPQLLSDGLVKVDMGLPRLLAGEIPTTLAPVEEKVISVPLEVAGKTWEVTCVNMGNPHCITFVEDVAAIELESIGPKFEHHPAFPQRINTEFIQVVRRDYLKMRVWERGAGITLACGTGACASLVAGVLTGKCDRTATVELPGGPLQIEWSEIDQRVYMTGPAERVFTGKL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP4AC_RAT
Sequence: MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHKIPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRSDPKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPESSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids.  Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids (PubMed:10620324, PubMed:10869363, PubMed:15618658).  May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:10620324, PubMed:10869363, PubMed:15618658).  At preglomerular arteries, may participate in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:15618658).  Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency, displaying a preference for the (R)-stereoisomer (PubMed:10869363).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10620324, PubMed:10869363, PubMed:15618658).
What are the official names of this protein?
Cytochrome P450 4A12, CYPIVA12, CYPIVA8, Cytochrome P450-KP1, Cytochrome P450-PP1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi- pass membrane protein.
Protein: PEX19_RAT
Sequence: MAAAEGGCGAGVEADRELEELLESALDDFDKAKPSPAPSPTISAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDASSQQEFTSCLKETLSGLAKNATDLQNSGMSEEELTKAMEGLGMDEGDGEGNILPIMQSLMQNLLSKDVLYPSLKEITEKYPEWLQSHQESIPPEQFEKYQQQHSVMGKICEQFEAETPTDSEATHRARFEAVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGANGEQCLIM
What is the function of this protein?
Necessary for early peroxisomal biogenesis.  Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs).  Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3.  Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
What are the official names of this protein?
Peroxisomal biogenesis factor 19, Peroxin-19, Peroxisomal farnesylated protein.
What is the protein family that this protein belongs to?
Belongs to the peroxin-19 family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Lipid-anchor; Cytoplasmic side. Note=Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes.
Protein: CHER_RHIEC
Sequence: MIYSDAGIFLNETKASLVYSRLSKHIRNLGLSGFREYCELVASPAGAAARREMLSHLTTNFTRFFRENHHFEHLRDHVLPELLQRARSGGRVRIWSAASSDGQEPYSIALTVLSLMPNVADYDFKILATDIDPKILAIARAGAYDESALETVSPAMRKQWFSEVEVQGRRKFQVDDRVKRLITYNELNLMAQWPFKGKFDVIFCRNVVIYFDEPTQMKIWQRFAGLLPEGGHLYIGHSERVSGEAKHVFDNIGITTYRYTTKGLGRKA
What is the function of this protein?
Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
What are the official names of this protein?
Probable chemotaxis protein methyltransferase.
Protein: MENG_BACVZ
Sequence: MQESKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMQIMNVKEGAKALDVCCGTADWTIALAEAAGKSGEIKGLDFSKNMLSIGEKKVKEGGYSQIELLHGNAMELPFADDSFDFVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMFGFRQAYFLYFKYIMPFFGKMFAKSYKEYSWLQESAREFPGMKELARLFEEAGLTNVKYHSFTGGVAATHIGWK
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: Y4456_PSESM
Sequence: MRMIIVSGRSGSGKSTALDVLEDNGFYCVDNLPAGLLPELAERALINTELAEPLLAVSIDARNLPSHLTRFPQMLDEVRSRNIQCDVLYLDADEATLLKRFSETRRRHPLSTADRSLAEAIRDETTLLGPIIDLADLKINTTHLNLYQLRDALKLRLLNKPEPGTAFLIESFGFKRGMPVDADLVFDVRCLPNPYWKPELRDHSGLEQPVIDYLSAQADVEEMFQDIFSYLNKWLPRFAASNRSYVTIAIGCTGGHHRSVYLTERLGQVLQQSLKNVQVRHRDLS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein PSPTO_4456.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: KDSA_RHOPT
Sequence: MNKSIAPATSVVAGNVKFGNALPLSVIAGPCQLESRAHALEVASALKEIATRLGIGLVYKTSFDKANRTSAASARGLGLDAALPIFAEIRDHLGLPVLTDVHENEQCARAAEAVDILQIPAFLCRQTDLLLAAAATGRIVNVKKGQFLAPWDMGNVVSKITHAGNAKVLVTERGVSFGYNTLVSDMRALPIMAKTTGAPVIFDATHSVQQPGGKGTSSGGEREYVPVLARAAVAVGVAGVFIETHPDPDHAPSDGPNMVPLREFEALIKTLMEFDALAKKRSTVGAV
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDKF4_ORYSJ
Sequence: MDRFKMIKEVGDGTFGSVWRAINKQNGEVVAVKKMKRKYYSFEECMSLREVKSLRRMNHPNIVKLKEVIRENDILYFIMEYMECNLYQLMKDRVKPFSEAEVRNWCFQIFQALAYMHQRGYFHRDLKPENLLVSKDVIKLADFGLAREVTSVPPYTEYVSTRWYRAPEVLLQSSIYDSAVDMWAMGAIMAELLTLHPLFPGTSEADEILKICNVIGSPDEQSWPQGLSLAETMKFQFPQVSGNQLAEVMTSVSSEAVDLISSLCSWDPCKRPKAAEVLQHTFFQGCTFVPPTVRSKAGVLPKTPPCVGVKGVSEHGMPRRYSTGTLSTTKPHSNASLKSSGLSKTGVQRKLQMDRQAPQKIKKPTESNNKLTTNRVPARNSPGHPVLRHSRSLPETGRATMHKVSTLTERLTHMSVTSRTRTTPKPAAPLLKAGLGKSDLLGKTDEIPPAKRLTRKLVS
What are the official names of this protein?
Cyclin-dependent kinase F-4, CDKF;4, Serine/threonine-protein kinase MHK-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: HLDD_ECO5E
Sequence: MIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQYSKELLHYCLEREIPFLYASSAATYGGRTSDFIESREYEKPLNVYGYSKFLFDEYVRQILPEANSQIVGFRYFNVYGPREGHKGSMASVAFHLNTQLNNGESPKLFEGSENFKRDFVYVGDVADVNLWFLENGVSGIFNLGTGRAESFQAVADATLAYHKKGQIEYIPFPDKLKGRYQAFTQADLTNLRAAGYDKPFKTVAEGVTEYMAWLNRDA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: RLMC_CITK8
Sequence: MQCALYDAGRCRSCQWIVQPIRDQLSAKTADLKGLLADFSVEQWCAPVSGPEQAFRNKAKMVVSGSVEKPLLGMLHRDGTPEDLSDCPLYPDTFAPVFATLKPFIARAGLTPYNVARKRGELKYILLTESQFDGGMMLRFVLRSETKLAQLRAALPWLQAQLPQLKVITANIQPVHMAIMEGETEIFLTEQQALAERFNDVPLWIRPQSFFQTNPVVASHLYATARDWVRQLPVHHMWDLFCGVGGFGLHCATPEMTLTGIEIAPEAIACAKQSAAELGLTNLHFQALDSTQFATGQGEVPELVLVNPPRRGIGKALCDYLSQMAPEYIIYSSCNAQTMAKDIANLPGYRIERVQLFDMFPHTAHYEVLTLLTKTR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: ZN181_HUMAN
Sequence: MPQVTFNDVAIDFTHEEWGWLSSAQRDLYKDVMVQNYENLVSVAGLSVTKPYVITLLEDGKEPWMMEKKLSKGMIPDWESRWENKELSTKKDNYDEDSPQTVIIEKVVKQSYEFSNSKKNLEYIEKLEGKHGSQVDHFRPAILTSRESPTADSVYKYNIFRSTFHSKSTLSEPQKISAEGNSHKYDILKKNLPKKSVIKNEKVNGGKKLLNSNKSGAAFSQGKSLTLPQTCNREKIYTCSECGKAFGKQSILNRHWRIHTGEKPYECRECGKTFSHGSSLTRHLISHSGEKPYKCIECGKAFSHVSSLTNHQSTHTGEKPYECMNCGKSFSRVSHLIEHLRIHTQEKLYECRICGKAFIHRSSLIHHQKIHTGEKPYECRECGKAFCCSSHLTRHQRIHTMEKQYECNKCLKVFSSLSFLVQHQSIHTEEKPFECQKCRKSFNQLESLNMHLRNHIRLKPYECSICGKAFSHRSSLLQHHRIHTGEKPYECIKCGKTFSCSSNLTVHQRIHTGEKPYKCNECGKAFSKGSNLTAHQRVHNGEKPNSVVSVEKPLDYMNHYTCEKSYRRETV
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 181, HHZ181.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: XRN2_CANGA
Sequence: MGVPSFFRWLSRKYPKIISPVLEEPQQLVDGVALPIDYAGPNPNGELDNLYLDMNGIVHPCSHPENKPPPETEDDMLLAVFEYTNRVLNMARPRKVLVIAVDGVAPRAKMNQQRSRRFRSARDAEIENEAREEIMRQKEQLGQIIDDSVKNKKTWDSNAITPGTPFMDKLAIALRYWTAFKLATDPGWKNLQVIISDATVPGEGEHKIMNFIRSQRADPEYNPNTTHCIYGLDADLIFLGLATHEPHFKILREDVFAQDNRKRNNVKDTIDMTDEEKDLIRKQDSEKPFLWLHISVLREYLSAELWTPKLPFPFDLERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILLDIWKSILPRLKTYMTCDGKLNLESVEMVLKELGNREGDIFKTRHIQEIRKKEANERRKQQKQQNVSTGQDRHPTKFNEQLQMYDTNGSLAKGSWNLTTSDMVRYKKELMLANEGDENSIKIIEEVSERNNSLMKEIQSEMTPEDYKGNNNNFTAAELLKKKLNARKRELEKEKENEEQERASKQPKISETPDESDLTEEIEADVIAEVEDETTPDEKDTDSIITEVPEISNGGITSGVIDTDEAVKLFEPGYHDRYYIEKFHIEPNQIPALSKHMVKCYIEGVSWVLMYYYQGCASWTWYYPYHYAPLAEDFVDFHDLDIKFELGEPFLPYEQLMSVLPAASGHNLPEVFRPLMSSEDSEIIDFYPTEFPIDMNGKKMSWQGIALLPFIDETRLLTATRNQYKFLSEDEKRRNTRNDPVLLISNKNVNYEKFAKRLYKKGHEDNFQLVFHHFKSSLAGIVSTDTEGFKLHAKLPCPIQSGALPELSTNLFLKMQYKLLPLPSANKSLILNGFIPSEPMLTQHDFDSIVYKYGTRGFQRNQRNFGMEMKQNIVPVGPSGTTQYKPRIGGYRSFFYFGQLNQQMHQHNQVYQQNQAPTHDRYRNDRSDRGGRGYGRPDHDRGDYRGDYRGDGYRGGHRGGYRGGSRSRGPSSRGISSRGYSGPSRYNR
What is the function of this protein?
Possesses 5'->3' exoribonuclease activity.  Required for the processing of nuclear mRNA and rRNA precursors.  May promote termination of transcription by RNA polymerase II (By similarity).
What are the official names of this protein?
5'-3' exoribonuclease 2.
What is the protein family that this protein belongs to?
Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVC_PARDP
Sequence: MKIIGIDPGLRNMGWGVIAVEGPRLRHLDNGIVHSEAGDLGPRLAALYRGLCAVIVRHAPDAAAVEQTFVNKDALGTLKLGQARGIALLAPAEAGLEIGEYAPNAVKKAVVGVGHAAKEQIQHMVRFMLPGVEFAGPDAADALAVAICHAHHLQGRALRIKASA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: QUEA_ECOL6
Sequence: MRVTDFSFELPESLIAHYPMPERSSCRLLSLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGAELLLGDDESINATMTARHGALFEVEFNDQRSVLDILNSIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQDVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPLFDDTQIFIYPGFQYKVVDALVTNFHLPESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WAPA_PSETE
Sequence: MSSGGLLLLLGLLTLWAELTPVSGQDRPKKPGLCPPRPQKPPCVKECKNDWSCPGQQKCCSYGCIDECRDPIFVN
What is the function of this protein?
Damages membranes of susceptible bacteria.  Has no hemolytic activity.  Not toxic to mice.  Does not inhibit the proteinases elastase and cathepsin G.
What are the official names of this protein?
Textwaprin-a.
What is the protein family that this protein belongs to?
Belongs to the snake waprin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLGC_MANSM
Sequence: MNNAVLNQPNKYDLVKDTLVLILAGGRGSRLHELTDKRAKPALYFGGNRRIIDFALSNCINSGLNRIGVITQYAAHSLLRHLQTGWSFLPQERGEFVDMLPARQQIDDNTWYRGTADSVYQNLAIIRGHYKPKYVLILAGDHIYKMDYSQMLLDHVSSGAKCTVGCIEVPREEAKEFGVMAVNETLKVKAFVEKPQDPPAMIGKPNSSLASMGIYVFNADYLYEALDRIKTPNTSHDFGKDVMPLALNDGVLYAHPFDRSCKGRNTEGAIYWKDVGTLDSFWQANIDLVSEEPQLDIYDQTWPIRGNPVQAYPSKFFYDEPNCKQVDNSLIAGGCMVKNASISYSVLFDNVSVNAGSSIEQSVILPQVKIGKNCMLRRCIIDRHVQIPDGMQIGVDLELDSKRFRISKNGIVLVTESMLHKLNGKSVASEAHLD
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: NFI_SULIN
Sequence: MVEKHLLEFLEKLQFLISKNVKISHYGIENVKKICGVDIAYKGNLGFSVGVSMDINSGDYNYKSYVGEVNFPYIPGFLFMREAPLMIKAIEGLDCHLLLVDGHGIAHPRKSGIATVIGVLLDFPTIGVAKSRLTGDLVNESEITYVYLNGEKVGVKFGRYFYSPGNKVDLQDCIELGKRGYPKVLKIADMLTKKIKKE
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_STAAB
Sequence: MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKERKLAIIAEIKSKSPTVNDLPERDLSQQISDYEKYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLVEVHDRHELERVYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHYYISESGIHDASDVRKILHSGIDGLLIGEALMRCDNLSEFLPQLKMQKVKS
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: FA89A_XENLA
Sequence: MSGSHTAIAPLAPCMEGLPPLPKSLSGLLNSSGGSGWRDLERVYAQKSRIQDDLSRGGTSGSVQAHPKPPNLDAALALLRKEMVGLRQLDMSLLCQLYSLYESIQEYKGACQAASSADCTYAMENGFFDEEEEYYQEAGSLHKIGRENSEGTVSPISNEDWILENI
What are the official names of this protein?
Protein FAM89A.
What is the protein family that this protein belongs to?
Belongs to the FAM89 family.