PharMolix/UniProtQA huggingface dataset:
Protein: HHA_ECOLI
Sequence: MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
What is the function of this protein?
Down-regulates hemolysin (hly) expression in complex with H-NS (PubMed:1956303, PubMed:10778755, PubMed:11790731, PubMed:21600204).  Stimulates transposition events in vivo (PubMed:8145648).  Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex (PubMed:23543115).  Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS (PubMed:23543115).  Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR (PubMed:19909729).  Decreases biofilm formation by repressing the transcription of fimbrial genes fimA and ihfA, and by repressing the transcription of tRNAs corresponding to rare codons, which are abundant in type 1 fimbrial genes (PubMed:18545668).
What are the official names of this protein?
Hemolysin expression-modulating protein Hha.
What is the protein family that this protein belongs to?
Belongs to the Hha/YmoA/Cnu family.
Protein: ETR2_SOLLC
Sequence: MDCNCFDPLLPADELLMKYQYISDFFIAVAYFSIPIELVYFVQKSAVFPYRWVLVQFGAFIVLCGATHLINLWTSTPHTRTVAMVMTTAKFSTAAVSCATAVMLVHIIPDLLSVKTRELFLKNKAAELDREMGLIRTQEETGRYVRMLTHEIRSTLDRHTILKTTLVELGRALQLEECALWMPTRTGVELQLSYTLHHQNPVGFTVPIQLPVINQVFSANCAVKISPNSAVARLRPTRKYIPGEVVAVRVPLLHLSNFQTNDWPELSPKSYALMVLMLPSNSARQWHVHELELVDVVADQVAVALSHAAILEESMRARDLLIEQNVALDLARREAETAVRARNDFLGVMNHEMRTPMHAVVALSSLLQESELIPEQRLMVETILKSSNLLATLINDVLDLSRLEDGSLQLDVGTFNLHALFREVLNLIKPVAAVKKLFVTLSLSSDFPEVAIGDEKRLMQILLNVVGNAVKFSKEGSVSVSAVNAKSESLIDPRAPEFFPVQSENHFYLRVQVKDTGSGINPQDFPKLFCKFAQNQEPATKNSAGTGLGLAICKRFVNLMEGHIWIESEGVGKGSTAIFIVKLGIPGRLNESKLPFTAGLPANHMQMTFQGLKVLVMDDNGFSRMVTKSLLVHLGCDVTTIGSGDECLRILTREHKVLIMDASITGMNCYDVAVSVHEKFGKRLERPLIVALTGNTDQVTKENCLRVGMDGVILKPVSIDKMRSVLSGLLEHGTVL
What is the function of this protein?
May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.
What are the official names of this protein?
Ethylene receptor 2, LeETR2.
What is the protein family that this protein belongs to?
Belongs to the ethylene receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRMD_RALSO
Sequence: MQFDVISLFPEMFRALTDWGITSRAAKQQVYTLRTWNPRDFTTDNYRTVDDRPYGGGPGMVMLAKPLEAALDAIREAQAPAPSHVVLLSPQGRPLTHRRVMELAQLPALTLLCGRYEAIDQRLVDRRVDEEISLGDFVLSGGEIAAMAIIDAVVRQLPGVLGDAQSAVQDSFVNGLLDCPHYTRPEEYEGVRVPDVLLGGHHAEIEKWRRQQALLNTMRKRPDLIEAARRQGLLSRSDEVFLAAAATTAKGSGASLSEAPAK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_BLOFL
Sequence: MKRCTKLKILNTFSVDVYAEKVIIINDEYSLLQLWKQSRDQDKFFLILGAGSNVLFLENYKGIVLLNRIKGIFVTENKVAWYLHVGAGEEWNTLVMYTIKRNMPGLENLVCIPGYVGAALIQNIGAYGVELSQMCEYVDVLDLNQGDKIRLYCHECCFRYRESIFKLNLYKYAILFVGLRINKHWKPVLSYSGLTHLNLNSITPRQIINTIIFLRYKKLPNPIIHGNVGSFFKNPVVDFKVVSFLLKKYSNIPYYFQEDGKVKLLAGWLIENCNLKGYILGEASVYYKQALVLINTRQKATGTEIAALALYVYNKVVDKFNIRLKPEVRLIGSFGEINPKKLFLK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN287_PONPY
Sequence: MLASSKRMNSSSRSQILLRWKSDKAQSGPYNVEKEILTSRFLRDTETCRQNFRNFPYPDLAGPRKALSQLRELCLKWLRPEIHSKEQILELLVLEQFLTILPGEVRTWVKSQYPESSEEAVTLVEDLTQILEEEAPQNSTLSQDTPEEDPRGKHAFQTGWLNDLVTKESMTFKDVAVDITQEDWELMRPVQKELYKTVTLQNYWNMVSLGLTVYRPTVIPILEEPWMVIKEILEGPSPEWETKAQACTPVEDMSKLTKEETQTIKLEDSYDYDDRLERRATGGFWKIHTNERGFSLKSALSQEYDPTEECLSKYDIYRNNFEKHSNLIVQFDTQLDNKTSVYNEGRATFNHVSYGIVHRKILPGEKPYKCNVCGKKFRKYPSLLKHQSTHAKEKSYECEECGKEFRHISSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICNICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNECDKDFSQRTCLIQHQRIHTGEKPYACRICGKTFTQSTNLIQHQRVHTGAKHRN
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 287.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATI_VAR67
Sequence: MEVTNLIEKCTKHSKDFATEVEKLWNDELSSESCLSRKTRNVIRNILRDITKSLTTDKKSKCFRILERSTINGEQIKDVYKTIFNNGVDAESRINTTGKYVLFTVMTYAAAELRLIKSDEIFALLSRFFNMICDIHKKYGCGNMFVGIPAALIVLLEIDHINKLFSVFSTRYDAKAYLYTEYFLFLNINHYLLSGSDLFINVAYGAVSFSSPISVPDYIMEALTFKACDHIMKSGDLIYIYAFTKKVKDLFNTKSDSIYQYVRLHEMSYDGVSEDTDDDDEVFAILNLSIDSSVDRYRNRVLLLTPEVASLRKEYSEAEPDYKYLMDEEVPAYDKHLPKPITNTGIEEPHATGGDKEDQPIKVVHPPNNDKDDAIKSYNPLEDPNYVPTITRTAIGIADYQLVINKLIEWLDKCEEECGNGGEFKTELEEAKRKLTELNAELSDKLSKIRTLERDSVYKTERIDRLTKEIKELRDIQNGTDDGSDSSEIDKKTIRELKESLDREREMRSELEKELDTIRDGKVDGSCQGRLELSRMWLKQRDDDLRAEIDKRRNVEWELSKLRRDIKECDKYKEELDKAKTTISNYVSRISTLESEIAKYQQDRDTLSAVRGELEEERRRVRDLESRLDECTHNQKDTQEVDALRSRISELENKLTDCIESGGGNLTEISRLQSRILDLERQLNDCRHNNKTNTETDRNETS
What is the function of this protein?
Structural protein that forms a matrix surrounding the mature virion (MV) through interaction with protein A26.  Presence of protein A25 in the virion structurally prevents direct virus-cell fusion mechanism (By similarity).
What are the official names of this protein?
A-type inclusion protein A25 homolog, ATI.
What is the protein family that this protein belongs to?
Belongs to the poxviridae A25 protein family.
What are the subcellular locations of this protein?
Virion. Note=Present above the membrane of mature virions (MV).
Protein: LRGUK_MOUSE
Sequence: MAAFERNPSRWKGTRFRRGLGASRIAAQAILSLTEKQSQGRWPSFPLGLKSKGTFRSASSYLLHQLIHRSHEAEAEQEEKQQEDGESEESEESEMQNLEDKYDGILREETVAEAITGLGWSGRGTEQVYLNLNLSHCELVDISILCGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNKLTTFFNFKPPQNLKKVDFSSNLISEMYDLSAYHTLTQLILDNNEIEEITGLENCISLTHLSLAGNKITTIKGLGTLPIKVLSLSNNMIETITGLEELKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIYMLLRLTELDQQKIKVEEKVFAVNKYDPPPEVVAVQDHMTHVVNSMSQPQRIWDSTLPSLDAPYPMLILTGPAACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQEVFDEMLNMGKFILTFNYGNHNYGLNRDTIEGIARDGLASCIHMELEGVRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNQKYPGYFDAVINADDMDIAYQKLSELIREYLGLTETAAKTLAPTADTKTSYLKCEDYSRKSSTVEFLDSTDRNYFTKLWAKLSSKKSPVERESLHRQHEAARQALMGKTPRDHTLLFQRGPVPIPTVSGQQYFATIDELQKTFELSDDLFKTPSGTYPETSKDSNISKRYSTYFHTCPWSKELPFQLPEGGISSRPGSAGSDEVDGALKALRVASSMQEKVAQHKRLSAITIMDPGSNTKPTLPPIPHGRR
What is the function of this protein?
Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development (PubMed:25781171).  Not essential for primary cilium biogenesis (PubMed:28003339).
What are the official names of this protein?
Leucine-rich repeat and guanylate kinase domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to the acrosome and acroplaxome in round spermatids. Localizes to the manchette during spermiogenesis. Also found in the basal body of elongating spermatids, and in primary cilia of somatic cells.
Protein: DNAJ_STRA5
Sequence: MNNTEFYDRLGVSKDASQDEIKKAYRRMSKKYHPDINKETGAEEKYKEVQEAYETLSDTQKRAAYDQYGAAGANGGFGGFDGGGFGGFDGGGFGGFEDIFSSFFGGGGMRNPNAPRQGDDLQYRVNLSFEEAIFGAEKEVSYNRESSCHTCSGSGAKPGTSPVTCQKCHGSGVINVDTQTPLGTMRRQVTCDVCQGSGQEIKEKCPTCHGTGHEKKTHKVSVKIPAGVETGQQIRLTGQGEAGFNGGPYGDLFVIINVLPSQQFERNGSTIYYTLNISFVQAALGDTIDIPTVHGAVEMSIPAGTQTGKTFRLRGKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQKEALHAFAEASGDKMVHPKKKGFFDKVKDALDVD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUS7_HUMAN
Sequence: MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASSEQLYFSTPTNHNLFPLNTLEST
What is the function of this protein?
Dual specificity protein phosphatase (PubMed:9788880).  Shows high activity towards MAPK1/ERK2 (PubMed:9788880).  Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880).  In arrested oocytes, plays a role in meiotic resumption (By similarity).  Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity).  May also inactivate PRKCA and/or PRKCG (By similarity).  Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).
What are the official names of this protein?
Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSBA_BORA1
Sequence: MIPGVREATAGHEPVKAELWKRIYSRVGSHWKGLILAVLLMAGAAATQPTLAVIMKPLIDGGFAGDKPQYIWSVPLAVIGLILLRGVCNFFSDYLLAWVANNVLLGIRREMFDRLLGLPDADFKRGDTGRLLNRFTIDAGNVTGYATDVITVLVRETLVVISLIAVLLYMSWLLTVIILVVMPISVWIARSFARRLRRINRETVNMNAELTRVVSEGIDGQRVIKLFDGYEAERGRFAYVNARLRRFAMRTAVADAALTPLTQVCIAVAVGAVIAVALGQANAGTLTAGAFAAFMSALAQIFDPIKRLTNLASKMQKMLVSAESVFTLVDQIPEVDEGQRTLAEPVRGKIEFRQIGHRFPEADRNTISDVSFTVEPGQTVALVGRSGSGKTTLVNMLPRFVLPTEGSILIDDVPINDVQLNSLRSHLSLVSQDVVLFDDTIAANVGYGALGKADDQRIHDALAAANLRDFVDSLPKGIHTPVGENAARLSGGQRQRLAIARALIKNAPILILDEATSALDNESERQVQSSLDRLMRGRTTLVIAHRLSTVQNADRIIVLDAGRIVEHGAHTELLAAGGLYATLYNMQFRED
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TMCAL_BACVZ
Sequence: MKAVGLVVEYNPFHNGHRYHAEQAKIKTDSSVAAAVMSGPFLQRGEPAAVSKWARTKMALENGVDIVIELPYIYAVQKAELFARGSVSLLHHLGCSSLFFGSENGRIEPFIEASEAFSRKEDDCSLILKEELKKGLSYPAAASKAFSHIFKGRDMLDLSKPNNILGFHYVRAIHTSGSAMKPYTTARIASQYHDAELPGDNSRIASATSIRKALIEKGTAAARSFLPEASARELEAYRNSYGIWHSTEDYFSYVKYSLSTLSAEELSRIYEVEEGLEHRILRTIRQARSYREMMERLKTKRYTWTRLQRMNTHILTRTKKEDMHRLLKPSSAPYIRLLGMTKKGQAYLSAKKKELTAPLVSKLSSFSHPALDLDILAGRVYSLPINEPERTLFEKQEFSQAPIRYDEDEKRFLNA
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTC36_XENTR
Sequence: MCTPNDLAVLHAIFNPNVPFGNFDEQNVGDTEANADLDGRFSSAILQQAQDLERDGVKAAESEDMATAILKFSEAIALLPERASAYNNRAQALRLQGDVKGALEDLNQAVELSGIAGVAGRQALVQRGLILRLQGKDDEARKDFQRAAQLGSDFAKQQLILLNPYAALCNTMLRDMMQKLREPNGHKIQVGASTSLEDDREA
What are the official names of this protein?
Tetratricopeptide repeat protein 36, TPR repeat protein 36.
What is the protein family that this protein belongs to?
Belongs to the TTC36 family.
Protein: DNLI_MYCUA
Sequence: MLLIDIASTSLNVGGTSSRLAKVARIAEPLRAAAPDPELVAIVVAWLSGELRQRQIGVGWATLRSPPAAAGSPALTVTGTDAAFSEIGAVSGKGSAARRRELITRLFAASTETEQAFLVRLLSGELRQGALAGIMVDAVARAAEVPATAVQRAAMLGGDLPTVAAACLAAGSSGAAGALDSFTLRVGRPIGPMLAQSAGSITDALERHGGATIFEAKLDGARVQIHRTGDEVTVYTRSLDDVTARLPEVVQATLALPVSDLVADGEAIALQPDGRPHRFQVTASRFGRSVNVAAAQAKQPLSVFFSDILHRDGRDLLDAPTTDRLAALDAVVPARHRVDRLTTADAAAATDFLRATLAAGHEGVMAKSPTAPYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIPLGARDAATGEFVMLGKTFKSMTDAMLDWQTARFTELAVGGTDGYVVALRPEQVVEVAFDGVQASSRYPGGLALRFARVVRYRDDKGPADADTIDTVRALY
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
Probable DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: RL24_NEOSM
Sequence: MKRIVSGDQVKVISGNEAGKVGVVRKVLYSSVGRRKEVYVIVSDVNVRRFVKKTQAGKKFDAKSYPIAVSNVALLAGDGFVSKVGFKLKDGTKKRIFKRTAEFV
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MRAY_NOCFA
Sequence: MRQILFAAAIALTVSILLTPALIKFFAKQGFGQEIRVDGPASHQSKRGTPTMGGVAILIGMWAGYLGSHLIGIAYDAEGPSASALLVLGLATALGAVGFIDDFIKIRKGRNLGLTAAGKYLGQLTAAIVFGVLALQFRGENGLTPASRHLSYVRDITTVSMGVIVFLAFVSLVVVAWSNAVNLTDGLDGLAAGSMSLVLGGYVIITFWQYYHACATKPETGCYNVRDPLDLALVCAAGTAACIGFLWWNAAPAKIFMGDTGSLALGGLLAGLSITTRTELLMVVIGALFVAEAASVVLQVAVFRTTRNRLFKMAPFHHHFELSKWAETTVIIRFWLLAAMASAFGLGLFYSEYLSAVG
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACOT5_MOUSE
Sequence: MVPTVSLEPTGHSCWDEPLSIAVRGLAPEQPVTLRTALRDEKGALFRAHARYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPFVVELEVLDGHEPDGGRLLARAVHERHFMAPGVRRVPVREGRVRATLFLPPGTGPFPGIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYKYDDLPKVIDILHLEYFEEAVTYLLSHPQVKGPGVGLLGISKGAELSLSMASFLKGITAAVVINGATVNVISTLYYKEESLPGLGMHLERIKVTKDGFKDIIDILNVPLEAPDQKSLIPLERSDTAFLFLVGQDDHNWKSEFYAREASKRLQAHGKEKPQIVCYPKTGHHIEPPYIPWSIAAPHSYFDKPILLGGEPRAHAMAQVDAWQRLQTFFHKHLSGDKRPSPAKL
What is the function of this protein?
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157).  Mainly active on medium-chain acyl-CoAs (PubMed:15007068).  Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels (PubMed:15007068).  May have a function in termination of beta-oxidation of fatty acids (PubMed:15007068).
What are the official names of this protein?
Acyl-coenzyme A thioesterase 5, Acyl-CoA thioesterase 5, Peroxisomal acyl-coenzyme A thioester hydrolase Ic, PTE-Ic, Peroxisomal acyl-CoA thioesterase Ic.
What is the protein family that this protein belongs to?
Belongs to the C/M/P thioester hydrolase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: MBP_HORSE
Sequence: ASQKRPSQRHGSKYLASASTMDHARHGFLPRHRDTGILDSLGRFFGGDRGVPKRGSGKDGHHAARTTHYGSLPQKSRDGRPQDENPVVHFFKINVTPRTPPPSQGKGRGLSLSRFSWGAEGQKPGFGYGARASDYKSTHKGLKGVHDAQGTLSRIFKLGGRDSRSGSPMARR
What is the function of this protein?
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS.  Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers.  Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
What are the official names of this protein?
Myelin basic protein, MBP.
What is the protein family that this protein belongs to?
Belongs to the myelin basic protein family.
What are the subcellular locations of this protein?
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
Protein: LMF2_MOUSE
Sequence: MASSRVPQQLFLQGVAAVYLFAFASLYTQIPGLYGPEGILPARRTLRPQGKGLWQQLWETPTLLWEAPRLGLDTAQGLDLLTLLGTVLALGALLLNSLRHPFVYLLLWVAYRSAYQVGQVFLYFQWDSLLLETGFLAILVAPLRGPSKHKILQGRLAGALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPTWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLTAFYAQALLQVLIIITGNYNFFNLLTLVLTTALLDDRHLSAEPGLRCHKKMPTSWPKALLTALSLLLELTVYGLLAYGTVYYFGLEVDWQQHIILSKTTFTFHQFSQWLKTVTLPTVWLGTASLAWELLVVLWRWIQVQGWSRKFSAGIQLSVLGTATVALFLISLVPYSYVEPGTHGRLWTGAHRLFGSVEHLQLANSYGLFRRMTGVGGRPEVVLEGSYDGQHWTEIEFMYKPGNVSRPPPFLTPHQPRLDWQMWFAALGPHTHSPWFTGLVLRLLQGKEPVIRLVQSHVANYPFHERPPTYLRAQRYKYWFSKPGDQSRWWHRQWVEEFFPSVSLGDPTLETLLQQFGLKDKSPPRARSPSNGLAQTLNWVRTQLSPLEPPILLWGLFGAVVAIRVVQTLLAPRPLQSSKQTREEKRKQTSKKDSRAASEQAAANSNSRDSWAPRRKK
What is the function of this protein?
Involved in the maturation of specific proteins in the endoplasmic reticulum.  May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).
What are the official names of this protein?
Lipase maturation factor 2, Transmembrane protein 112B, Transmembrane protein 153.
What is the protein family that this protein belongs to?
Belongs to the lipase maturation factor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: O17A_CONMA
Sequence: MKLTCVVIVAVLLLTACQLITADDSRGTQKHRALRSTTKLSTSTRCKGKGAKCSRLMYDCCTGSCRSGKCG
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels.  This toxin blocks Cav2. 2/CACNA1B calcium channels (IC(50)=0. 67-208 nM) (PubMed:7826361, PubMed:26344359, PubMed:34589389).  It acts by neutralizing the outer electronegativity and sterically hindering the ion access path to the entrance of the channel selectivity filter (PubMed:34234349).  It also shows antiproliferative effects on different glioma cell lines (M059J, U-138MG and U-251MG) (PubMed:28202361).  In vivo, is lethal to fish (PubMed:26344359, PubMed:34589389).  In vivo, injection into mammals induces adverse effects, such as tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion (PubMed:26344359).  In addition, it causes reduction of tumor area in the mouse glioma model, that is induced by the orthotopic injection of GL261 cells into the brain (PubMed:28202361).
What are the official names of this protein?
Omega-conotoxin MVIIA, SNX-111.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GP44_BPSP1
Sequence: MAKSNNVYVVNGEEKVSTLAEVAKVLGVSRVSKKDVEEGKYDVVVEEAAVSLADTEEVVEEVVTEEEDILEGVEVVEDEEEEEAAEDVEEPTSEEDSEDEWEEGYPVATEVEEDEDEEIEYPEVGDFEDEKAIKKYIKGLTDEQLQAWCELEGAEWVENEHRNINRMRMAMAIKAVHFPELAKKPSSKKKSKYAEYTTEELVEMAIDNNVEVRDDKGNERILRMYTIIALREAGLIS
What is the function of this protein?
Hypothesized to function in the shutoff of host biosyntheses.  But it seems dispensable both for host shutoff and for phage multiplication.  Its shutoff function is probably not entirely specific to host activities.
What are the official names of this protein?
E3 protein, Gene 44 protein.
Protein: URED2_BRUA2
Sequence: MLGKARELANYQDEPEQLPTGSFGKNAFLRLGFERRPERTVLATLHRRAPLIVQQALYWDEGMPTLPCVSIISNAGGILQGDRYAIEIDLEPDTQAHVTTQSATRIQEMDANFATQTQTQTITLGANSYLEYIPHPIIPHKHSRFVQQTEVTIHPTATLIYSEVLMAGRKYYGTGELFHYDLFSSKFHAAHTDGTSLFTEKFIVEPARGNVSRLGAMGSFHVFGNLILLTPKTHADRLFETIDPVFDMDEGIAWGASRLPNDAGLLFKVLGMESAPVRAAIRKIWEAARQEVTGASLPENFLWA
What is the function of this protein?
Disrupting the ure2 operon has no effect on urease activity or pathogen survival in BALB/c mice when administered orally.
What are the official names of this protein?
Urease accessory protein UreD 2.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA2_MOUSE
Sequence: MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYGSSLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSPPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG
What is the function of this protein?
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells.  Binds to the consensus sequence 5'-AGATAG-3'.
What are the official names of this protein?
Endothelial transcription factor GATA-2, GATA-binding protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIOB_NEIMB
Sequence: MTVSPVALRRKTECKPHPTARYWKKCDVEALFGLPFLDLIYQAAEIHRQNFNPREIQLSTLLSIKTGGCPEDCAYCPQSAHHNTNLGKEQMMDVDEIVEKAKIAKSRGASRFCMGAAWRGPKPKDVETVSAIIKAVKGLGMETCGTFGMLEEGMAEDLKEAGLDYYNHNLDTDPDRYNDIIHTRQHEDRMDTLGKVRNAGLKVCCGGIVGMNETRAERAGLIASLANLDPQPESVPINRLVKVEGTPLADAEDLDWTEFVRTIAVARITMPQSYVRLSAGRSNMPEAMQAMCFMAGANSIFYGDKLLTTGNPDEDGDRILMEKLNLYPLQFEPEGEVAEVEKASGIKVDY
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: Y453_AQUAE
Sequence: MGTLRKLLNALFLCLWDAFRYDYSYHASALTLQLLLVLAPLIVFLAALSSYLGFIKLDLLEEVLREHFPKQTHAVIAEILKAKEQGKTASLISLLVSYFFSVNFVKKIAKSLSYVVERKKRDVHEVFFWVGFPILLVLFSFVTGMSFYVSILLKTYFKGIGFLSNLASSLPLLFLVISLYWSFIKINRKISLLISSFLVYFFASLLQYIFTLYTVYVFKGSVLYGSLSTIVLFFLWLNFNFLLFLVGARFIERYESS
What are the official names of this protein?
Uncharacterized protein aq_453.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.