PharMolix/UniProtQA huggingface dataset:
Protein: PUR5_SYNE7
Sequence: MNYREAGVDIEAGRAFVGDIRSLVESTRRPGVLGGLGGFGGFFELPSGYRQPVLVSGTDGVGTKLKIAHQVGRHDSIGIDLVAMCVNDILTAGAEPLYFLDYLATGRLDREQLTAVVQGIAAGCRESGCALLGGETAEMPGFYEAGEYDVAGFAVGIAEKSELLDGSQVQLGDVAIALASSGVHSNGYSLVRKVVANSGLDWTSSQTIFEGQSLGDVFLTPTRLYVKPILAAKAQKIPIHGMAHITGGGLPENLPRCLGPNQTVAIDLESWKWPTVFRWLAKQGNIADSEMFNTFNMGVGLVVIVPAAAETQALKFFKAQGQTAWTLGEVVTGDGTLIGLP
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBD_PSEUK
Sequence: MRRLFLFFALLISGVAQAGTNPFETKPDFLPVGKAFVFTSERLESGETQLYWQIADGYYLYQKRLKFDGLPAEQHPALPEGETHSDEFFGEQQVYRQGLELKIAAGATGQIKVGFQGCADAGLCYPPHTQVVDLGGYLRYRCDRRSTGPSPGQRLQQRALGWSLLVFFGLGLLLAFTPCSLPMLPILAGLIVGSGATPKRGFALATSYVVSMALVYAAMGVLAAMLGANLQALLQNPWLLGSFAAVFVLLALPMFGFFELQLPVAVRDRLENVSRNQRGGSLFGAGVLGALSGLLVGPCMTAPLAGALLYIAQSGNALHGGLILFAMGIGIGVPLLLLVTVGNRFLPKPGAWMNLLKGVFGFLFLATALLMLRPVLDESLWIGLCGGLLLIAAYSAWKQSEGFGRVAHVFGASSLLLGVWGSLLMIGAAGGSDDLMKPLQVYSASNSSSAANPVSHDAFTTIKDPAALQRELDEAQAQGQWVLLDYYADWCVSCKVMEKQVFGKAHVMEALSDVRLLRLDVTADNAASRELLGRYKVPGPPSLLWIGADGIERRSQRITGEVDAGTFLQRWTTTRDAH
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HAP40_MOUSE
Sequence: MAAGSASSLGGGAWPGSEAGDFLARYRQVSNKLKKRFLRKPNVAEAGEQFAQLARELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQECDARQRLGCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAALCLELAAALRAVGQPAAAAGHFQRAAQLHLPLMPLAALQALGDAASCQLLARDYTGALALFTRMQRLAREHGGHPVQQLELLPQPPSGPQPPLSGPQPRPVLGSTLPLPQPPDHAPGSVAPSPGTLGAFADVLVRCEVSRVLLLLLLQPPPAKLLPEHAQTLEKYSWEAFDGHGQDTSGQLPEELFLLLQSLVMAAQEKDTEGIKKLQVEMWPLLTAEQNHLLHLVLQETISPSGQGV
What is the function of this protein?
RAB5A effector molecule that is involved in vesicular trafficking of early endosomes.  Mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity).  The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778).
What are the official names of this protein?
40-kDa huntingtin-associated protein, CpG island protein, Factor VIII intron 22 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Early endosome. Nucleus, nuclear body. Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (By similarity). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (PubMed:11035034). Colocalized with HTT in endosomes (By similarity). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (PubMed:23749422).
Protein: ALL3_AEDAE
Sequence: MKPLVKLFLLFCLVGIVLSRPMPEDEEPVAEGGDDDASGESEGEEETTDDAGGDGGEEENEGEEHAGDKDAGGEDTGKEENTGHDDAGEEDAGEEDAGEEDAGEEDAGEEDAEKEEGEKEDAGDDAGSDDGEEDSTGGDEGEDNAEDSKGSEKNDPADTYRQVVALLDKDTKVDHIQSEYLRSALNNDLQSEVRVPVVEAIGRIGDYSKIQGCFKSMGKDVKKVISEEEKKFKSCMSKKKSEYQCSEDSFAAAKSKLSPITSKIKSCVSSKGR
What are the official names of this protein?
30 kDa salivary gland allergen Aed a 3.
What are the subcellular locations of this protein?
Secreted.
Protein: DEOB_SHEPA
Sequence: MKRTIIMMLDSFGVGAAHDAEAFGDVGSNTFGHIAKACAEGKANDGREGPLKLPNLARLGLGHASKESTGEFPAGFGDDVEVIGAYGHADELSSGKDTPSGHWEMAGVPVLYEWGYFSELTNSFPQALTDKILARAGLTEFLGNCHSSGTVILDELGEEHMRTGKPIFYTSADSVFQIACHEESFGLEKLYELCIIAREELADYNIGRVIARPFVGTGPGSFERTGNRRDYAVEPPAPTVLDKLKAAGGEVVSVGKIADIYAHCGITKKVKATGLEALFDATLEQVKLAGDNTIVFTNFVDFDSHYGHRRDVAGYARSLEYFDSRLPEILALLDEDDFLLLTADHGCDPTWPGSDHTRERVPVLAYGAGLEAGSLGLRSSFADMGQSIASYFKLEPMEYGESFIR
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CF120_HUMAN
Sequence: MAAPRGRAAPWTTALLLLLASQVLSPGSCADEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHPSFDDYELQSATCGPDAVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKHAGAPEDASQEEESVLWTILISILKLVLEILF
What is the function of this protein?
May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
What are the official names of this protein?
UPF0669 protein C6orf120.
What is the protein family that this protein belongs to?
Belongs to the UPF0669 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted by hepatocytes.
Protein: DMRT1_BOVIN
Sequence: MPNDDAYSKPSAPSEAPQTPGAPPQGKAGGGGGGSGSDSGASGTGAVSGKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSTAELMVKRENSSGNPCLMIESSSSSQPPPASTPSTAAPGPEGRMVIQDIPAVTSRGHVENTPDLVSDSTYYSSFYQPSLFPYYNNLYNYPQYPMALAADSSSGDVGNPLGGSPVKNSLRSLPAPYVPGQTGNQWQMKNSENRHAVSSQYRMHSYYPPPSYLGQSMSQIFTFEDSASYSEAKASAFSPPSSQDSGLVSLPSSSPIGNESTKAVLDCESASEPSNFAVAPIIEEDE
What is the function of this protein?
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation.  Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm.  Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1.  Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes.  May act as a tumor suppressor.  May also play a minor role in oogenesis (By similarity).
What are the official names of this protein?
Doublesex and mab-3 related transcription factor 1.
What is the protein family that this protein belongs to?
Belongs to the DMRT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: E1183_AMBTT
Sequence: MTRNWSFRVIFVSAMWCALLKFATLEAPKDDFEYDGGCPFVVLDNGTHVKPAGCSHLCNGAPETLDNIECYNVTEEVAKRMTPGIPYACWLGWCSKGECKRDNRTEVCYRGSEEE
What is the function of this protein?
Salivary chemokine-binding protein which binds to host chemokine CCL2.
What are the official names of this protein?
Evasin P1183.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBI_GOSBA
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ATPE_KLEP3
Sequence: MAMTYHLDVVSAELQMFSGLVEKIQVTGSEGELGIYPGHAPLLTAIKPGMIRIVKQHGHEEFIYLSGGILEVQPGSVTVLADTAIRGQDLDEARALEAKRKAEEHIKSSHGDVDYAQASAELAKAIAKLRVIELTKKAM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LT01_HORVU
Sequence: MGSATVLEVILAIILPPVGVFLRYKLGVEFWICLLLTILGYIPGIIYAVYVLVV
What are the official names of this protein?
Low temperature-induced protein lt101.1, Blt101.1, Blt101.
What is the protein family that this protein belongs to?
Belongs to the UPF0057 (PMP3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ARNC_SALPA
Sequence: MFDAAPIKKVSVVIPVYNEQESLPELIRRTTAACESLGKAWEILLIDDGSSDSSAELMVKASQEADSHIISILLNRNYGQHAAIMAGFSHVSGDLIITLDADLQNPPEEIPRLVAKADEGFDVVGTVRQNRQDSLFRKSASKIINLLIQRTTGKAMGDYGCMLRAYRRPIIDTMLRCHERSTFIPILANIFARRATEIPVHHAEREFGDSKYSFMRLINLMYDLVTCLTTTPLRLLSLLGSVIAIGGFSLSVLLIVLRLALGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYNDVRARPRYFVQQVIYPESTSFTEESHQ
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAA_STRRE
Sequence: MADVPADLAAVWPRVLEQLLGEGRGQGVEAKDEHWIRRCQPLALVADTALLAVPNEFAKGVLEGRLAPIVSETLSRECGRPIRIAITVDDSAGEPPPAAPPAQQTPKPRYEEPELPSGPYEGYGRHRGGADQLPGTEPRPEQLPSARPDQLPTVRPAYPSEYHRPEPGAWPRPAQDEYGWQQPRLGFPERDPYASPSSQDAYGSPSQDYRPQGMDRPPYEQQRGDYDTPRAEYEPARPDYDSARPDYESARPEYDQRDPVRRELPEPPAHRGGPGADMPSAGAPGPPAAQPAPASGPGEPTARLNPKYLFDTFVIGASNRFAHAAAVAVAEAPAKAYNPLFIYGESGLGKTHLLHAIGHYARSLYPGTRVRYVSSEEFTNEFINSIRDGKGDSFRKRYREMDILLVDDIQFLADKESTQEEFFHTFNTLHNANKQIVLSSDRPPKQLVTLEDRLRNRFEWGLITDVQPPELETRIAILRKKAVQEQLNAPPEVLEFIASRISRNIRELEGALIRVTAFASLNRQPVDLGLTEIVLKDLIPGGEDSTPEITATAIMAATADYFGLTVDDLCGSSRGRQLVTARQIAMYLCRELTDLSLPKIGAQFGGRDHTTVMHADRKIRALMAERRSIYNQVTELTNRIKNG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPT_TREDE
Sequence: MSDELKHIAIVMDGNGRWAKKRGLPRSMGHKEGLNTVKRITKAVSDLGIPYITLYIFSTENWKRTEAEVGFLMGLIKQHLKAELKFYADNNIRIEHIGNLSGLPQDIQDEINSVRDKTSAYTGTAIVLGINYGAHDEILRAIKKLNSDELASINEESFSLKLDTGKIPPVDLLIRTGGEKRLSNFLLWQSAYAELYFTDTLWPDWTVENLYEAIEDYKKRNRRYGNA
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: GCVA_ECOLI
Sequence: MSKRLPPLNALRVFDAAARHLSFTRAAEELFVTQAAVSHQIKSLEDFLGLKLFRRRNRSLLLTEEGQSYFLDIKEIFSQLTEATRKLQARSAKGALTVSLLPSFAIHWLVPRLSSFNSAYPGIDVRIQAVDRQEDKLADDVDVAIFYGRGNWPGLRVEKLYAEYLLPVCSPLLLTGEKPLKTPEDLAKHTLLHDASRRDWQTYTRQLGLNHINVQQGPIFSHSAMVLQAAIHGQGVALANNVMAQSEIEAGRLVCPFNDVLVSKNAFYLVCHDSQAELGKIAAFRQWILAKAAAEQEKFRFRYEQ
What is the function of this protein?
Regulatory protein for the glycine cleavage system operon (gcv).  Mediates activation of gcv by glycine and repression by purines.  GcvA is negatively autoregulated.  Binds to three sites upstream of the gcv promoter.
What are the official names of this protein?
Glycine cleavage system transcriptional activator, Gcv operon activator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAPA_SALPK
Sequence: MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPMLRMKDGSYHKDGEFTPVSWEQAFDVMEEKFKTALKEKGPEAIGMFGSGQWTIWEGYAAAKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGSNMAEMHPILWSRITNRRLSDPNVKVAVLSTFQHRSFELADNGIVFTPQSDLVILNYIANYIIQNNAVNQDFFTKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFDEYKAFVAEYTLDKTAEMTGVPKDQLEQLAQLYADPNKRVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFSHRLPADMVVTNEKHRDICEKHWQIPAGTIPAKVGLHAVAQDRALKDGKLNVYWVMCNNNMQAGPNINEDRMPGWRDPRNFIIVSDPYPTVSALSADLILPTAMWVEKEGAYGNAERRTQFWRQQIKAPGEAKSDLWQLVQFSRRFKTEEVWPEALLAQKPELRGKTLYDVLFATPAVSKFPLSELKEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHNARGLRWPVVEGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAESPDNEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVVFIHPLDAKARDLRRGDKVKVSSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNNLTLDATDPLSKETDFKKCAVKLAKV
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: MURD_COXBN
Sequence: MSSESLTVIVGLGKTGLSCAQFLAAKNRPFAVMDSREEPPEWENFIKTYPRVELIRGQFSEKLLNEAQEIILSPGVSLQEPLIAKQAAQGKSIIGDIELFARNVNKPIIAITGSNGKTTVTTVVGLMMKAAGRNVSVCGNIGEPVLEQITPEPDYYVLELSSFQLETTFSLRSQAATILNISEDHMNRYATLQDYLRAKQRIYTDCFIPIVNADEPEIWRHLPFNKKPLSFGLNNAADFSLAEHNQKTSIAYQGKILMPIQELKLNARHHLQNALAALALGTAAKIPIENMLHVLRDFSGIRHRCQWVRKYKEIDYYNDSKGTNVGATRAAIESLGQAAKGQLILIAGGQGKGADFSPLKDVVKRYVKQVILIGEDAPLLEKTLKEITVIKHADSMNEAVKRSTQAAKAGDIVLLSPACASFDMFTNYEHRGDVFTETVEAL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_SULNB
Sequence: MAKKKAKKSIAKGVVYVAATFNNTVITVTDEMGNVISWSSAGALGFKGSKKSTPFAATEAVADAMAKAKENGIKEVGIKVQGPGSGRDTAVKAIGATEGIRVTFLKDITPLPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: SYS_DESA1
Sequence: MSWSILTLLRDNPELLKEHVKKRFMDPSLVDEAYKLDLEWRRLLSQVQELRHRHNVISRDISKLPEPERSARINEARELLSQMEELEKKLKEIEDLREEALLKLPNIVHETVPVGPDDTYNVPIRFWGKPKVWSGYIEQFMQQTERYGFKVEYELVNWKPVGHADMLEYVLRLGDTVKAGEVAGSRFYYLFDDIVFLDIALLMYAIDSLTSKGYKLVLPPYMLRHKVMSGVIDLATFKDAIYKIEGEDLYLIATAEHSLAALHAFEEIPEEELPLKYVGVSPCFRKEAGAGNRDLKGIFRVHQFHKVEQYVYAKPEESWALMEELIGNAEDLFKGLELPYRVVNIASGDLGAPAAKKYDLETWMPAQGLFREMVSCSNTTDWQSYRLKTRLVRRKGMVKEYVHTLNSTAIASTRTITSILENRQNEDGTVTVPRVLRKYLEVFNKAPRDYIHPVKRERA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DING_SALCH
Sequence: MALTAALKAQIAAWYKALQDQIPDFIPRAPQRQMIADVARTLAGEEGRHLAIEAPTGVGKTLSYLIPGIAIAREEQKTLVVSTANVALQDQIFSKDLPLLRKIIPDLRFTAAFGRGRYVCPRNLAALASSEPTQQDLLAFLDDELTPNNQEEQKRCARLKGDLDGYKWDGLRDHTDIAIDDDLWRRLSTDKASCLNRNCHYYRECPFFVARREIQEAEVVVANHALVMAAMESEAVLPEPKHLLLVLDEGHHLPDVARDALEMSAEITASWYRLQLDLFSKLVATSMEQFRPKTTPPLANPERLNAHCEEVYELIASLNAILNLYMPAAQEAEHRFAMGELPDEVMEICQRLAKLTETLRGLAESFLNDLSEKTGSHDIVRLHRVILQMNWALGMFEAQSKLWRLASMAQSSGAPVSKWATREIREGQLHVWFHCVGIRVSDQLERLLWRSVPHIIVTSATLRSLNSFSRLQEMSGLKEKAGDRFVALDSPFNHVEQGKLVIPQMRYEPTIDNEEQHIAEMAAYFREQLESKKHHGMLVLFASGRAMQRFLEHVADVRLLLLVQGDQPRYRLVELHRKRVESGERSVLVGLQSFAEGLDLKGELLTQVHIHKIAFPPIDSPVVITEGEWLKSLNRYPFEVQSLPSASFNLIQQVGRLIRSHACRGEVVIYDKRLLTKNYGQRLLNALPVFPIEQPAVPDVIVKPKAKPARRRRR
What is the function of this protein?
DNA-dependent ATPase and 5'-3' DNA helicase.
What are the official names of this protein?
ATP-dependent DNA helicase DinG.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.
Protein: PLSX_STRMU
Sequence: MKKIAVDAMGGDNAPQAIVEGVNQALADFSDIEIQLYGDEAKIKTYLKANDRVSIIHTDEKINSDDEPVKAIRKKKQASMVLGAQAVKDGKADAVLSAGNTGALLAAGLLVVGRIKNIDRPGLMSSLPTIDGKGFNMLDLGANAENTAHHLHQYAILGSFYAKNVRGVAHPRIGLLNNGTETTKGDPLRKETFALLAADETLNFIGNVEARDLMNSVADVVVTDGFTGNAVLKSIEGTALGIMEQLKTSIKQAGLRAKLGALLLKNSLYDLKDSLDYSGAGGAVLFGLKAPVVKCHGSSDAKSVYYTIKQIRIMLETDVVGQLVEEFSNRGD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: UBC_ASFB7
Sequence: MVSRFLIAEYRHLIENPSENFKISVNENNITEWDVILRGPPDTLYEGGLFKAKVAFPPEYPYAPPKLTFTSEMWHPNIYPDGRLCISILHGDNAEEQGMTWSPAQKIDTILLSVISLLNEPNPDSPANVDAAKSYRKYVYKEDLESYPMEVKKTVKKSLDECSPEDIEYFKNAASNVPPIPSDAYEDECEEMEDDTYILTYDDDEEEEDEEMDDE
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:29472632).  Performs the second step in the ubiquitination reaction that targets specifically a protein for degradation via the proteasome (PubMed:29472632).  By controlling the ubiquitination status of specific host proteins, the virus may target them to degradation and thereby optimize the viral replication (PubMed:29472632).  May be implicated in the shutoff of protein synthesis through its interactions with components of the host translation machinery (PubMed:33384682).  Blocks host RELA nuclear translocation upon cytokine stimulation, thereby impairing NF-kappa-B signaling (PubMed:34204411).  Inhibits type I IFN production and 'Lys-63'-linked polyubiquitination of host TBK1 through binding to host RNF138.  This binding enhances the interaction between RNF138 and RNF128 and promotes RNF138-mediated degradation of RNF128 (PubMed:34759016).  Also inhibits the activation of AP-1 transcription factor (PubMed:34204411).  Monoubiquitinates the viral protein P15/PIG1 in vitro (PubMed:7853518).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2, E2 ubiquitin-conjugating enzyme, UBCv1, Ubiquitin carrier protein, Ubiquitin-protein ligase, pI215L.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Virion. Note=Accumulates in the perinuclear cytoplasmic viral factories. Faintly detected in the nucleus.
Protein: NU4LM_LAGAL
Sequence: MSLVHINVLIAFTVSLTGLLMYRSHLMSALLCLEGMVLSLFILAALTILNTHFTLANMMPIILLVFAACEAAIGLALLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ADPP_NPVAC
Sequence: MRNAAGLFMIIEPDKAVLLCARRAYRSANAPAADMNDTFLEKISIPRGHRDCCDAKVYETAVREFVEETGRFFDSAFIYKLPFTLQWKDDGVTYKYLIYVGVVRGNLINVNAKPNTYTVKLLPGTFGNDYRIMLKPRRFNCEIARSLAIVPLNKYFNYMNDKQLITYDYSNYIEFFDFVRSVKARFDNRQLQDFFYATLKKIDNDAPQKLHALRRV
What is the function of this protein?
Plays an important role in virus replication most probably through its hydrolyzing ADP-ribose activity in host cells.  May function in viral DNA replication or transcription directly, or by removing toxic substances or metabolic intermediates.
What are the official names of this protein?
Protein ADP-ribose pyrophosphatase ORF38, ORF7.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: LPXK_PARXL
Sequence: MSEISNRLEARLAREWQQRGPLAWALTPFACVFGAIAAARRAAFSFGWLKSVRVGVPVVVVGNVTVGGTGKTPTVIALVEALRVAGFNPGVVSRGYGARVTTPTQITPASAASVGGDEPLLISRRTGAPVWVCPDRVAAAQALCAAHREVDVIVSDDGLQHYRLQRDVELVVFDHRLGGNGFLLPAGPLREPLSRRRDATLINDPYARTLPAWPNTFALQLAPGDAWHLDNPALRRPLAQFSGDRVLAAAGIGAPERFFATLRAAGLTPATRALPDHYAFERNPFTDVDADTILITEKDAVKLGSWHDARIWVVPVEAALDHRLIALVVEKVRGRSPA
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: PHTF2_CHICK
Sequence: MASKVTDARDWYQKKIGAYDQQIWEKSVEQREIKGLRNKPKKTGHVKPDLIDVDLVRGSAFAKAKPESPWTSLTRKGIVRVVFFPFFYRWWLQVTSRVIFFWLLVLYLLQVAAVVLFCTAQSPHNIPLTEVIGPIWLMLLLGTVHCQIVSTRTPKPPPSTGVKRRRKLRKAAHLEVHREGDGSSTTDNTQEGTVQSYGTSTSYSIGAVFRDIWHAAFFLSGSKKAKNSIDKSTETDNGYVSLEGKKTGKSSEECAQAQERLCEVIKPEESGWSTTTMRETFGTPSHHKETHRTVTNLSDEVSSEEGPETGYSLRRNVERTSSDGTLRNRKSHHYKKHYPLEDTPKSGTSCSSRCSSSRQDSESTRPESETEDVWEDLLHCAECHSSCTSETDVESPQMNPCVKKEYRDDPFHQSHLPWIHSLNPGLEKISAIVWEGNDCKKADMSVLEISGMIMNRVNSYIPGIGYQIFGNIISLILGLMPFVFRLSQAKDLEQLAAHSATELCITAFGSNGDILVLSMVVISFVVRVSLVWIFFFLLCVAERTYKQRLLFAKLFGHLTSARRARKSEVPHFRLKKVQNIKMWLSLRSYLKRRGPQRSVDVIVSSAFLLTISVVFICCAQLLHMHEIFLDCHYNWELVIWCISLTLFLLRFVTLGSETSKKYSNTSILLTEQINLYLKMEKKPNKKEELTLVNNVLKLATKLLKELDSPFRLYGLTMNPLLYNITQVVILSAVSGVISDLLGFNLKLWKIKS
What are the official names of this protein?
Protein PHTF2.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.