PharMolix/UniProtQA huggingface dataset:
Protein: MUG_CROS8
Sequence: MINDILEPGLRVVFCGINPGKSSAHTGFHFAHPGNRFWKVIHLAGFTDRQLKPEEERHLLDTRCGITKLVERPTVQANEVDVKELHEGGRNLIKKIEDFQPDALAVLGKKAYEQAFSQRGVKWGKQKLKIGKTEIWVLPNPSGLNRASLDKLVEAYRELDDALVARGR
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBF_STAER
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVFFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MDTI_KLEP3
Sequence: MQQFEWIHAAWLAVAIVLEIIANVFLKFSDGFRRKVYGILSLAAVLGAFSALSQAVKGIDLSVAYALWGGFGIAATIAAGWVLFGQRLNNKGWAGLILLVAGMVLIKLA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtI.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y111_UREPA
Sequence: MNYKYSAEEKQIIYNYILREYGQVDHIIFLSNEHIRVPIEYDILVIKKQNLQILMTFGLGAFKSHNHEENTQERAEIFLELPVDWDFNKHENMWPVHFLINIVKYSYSNHLTLKWLQTFINPSYFNKSNKIAGFLDLSWYGENSLECKINNDFFVSFYQILIIDDEELFYAKTNGIRALSKFFDDGKSRIVDLNRKSFVK
What are the official names of this protein?
Uncharacterized protein UU111.
Protein: PLPR1_RAT
Sequence: MAVENNTQRSYSIIPCFIFVELVIMAGTVLLAYYFECTDTFQVHIQGFFCQDGDLMKPYPGTEEESFISPLVLYCVLAATPTAIIFIGEISMYFIKSTRESLIAEEKMILTGDCCYLSPLLRRIVRFIGVFAFGLFATDIFVNAGQVVTGHLTPYFLTVCQPNYTSTDCRAHHQFINNGNICTGDLEVIEKARRSFPSKHAALSIYSALYATMYITSTIKTKSSRLAKPVLCLGDLCTAFLTGLNRVSEYRNHCSDVIAGFILGTAVALFLGMCVVHNFKGTQGSASKPKPEDPRGVPLMAFPRIESPLETLSAQNHSASMTEVT
What is the function of this protein?
May play a role in neurite outgrowth and neurogenesis.
What are the official names of this protein?
Phospholipid phosphatase-related protein type 1, Inactive 2-lysophosphatidate phosphatase PLPPR1, Lipid phosphate phosphatase-related protein type 1, Plasticity-related gene 3 protein, PRG-3.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection.
Protein: FABZ_THET8
Sequence: MDIREILKVLPHRYPFLLVDRVLEADERRFKALKNVTFNEPHFQGHFPGHPVMPGVLILEAMAQAAVGALVRQPGFPQGGLAFLAGVEGARFRRPVYPGDTLILEGELLAFRRGVGKVAVRALVEGEERASATLTFVLQGAS
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR14_AETCO
Sequence: MAKKSLIYREKKRQKLEEKYHLIRRSSKKEISKIPSLSDKWKIHGKLQSPPRNSAPTRLHRRCFSTGRPRATYRDFGLSGHILREMVHACLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MODC_RHIL3
Sequence: MTLIVEAKQRLDAFSLDAAFTSERGVTALFGRSGSGKTSMIRIIAGLARPDEGRVVLDGEPLTETTTGIFVPKHRRRFGYVFQEARLFPHLSIRANLTYGRWFAARTAHGESFDHIVDLLGIETLLERSPAKLSGGEKQRVAIGRALLSSPRLLLMDEPLAALDDARKAEILPYLERLRDETDIPIVYVSHSIAEVARLANQVVVMRDGKVEATGPAIDILSRPSTASDRREAGALLEGTVESFDARHHLSTVALKSCQVHIPGAALAPGKSVRIRIPSRDVMLATTRPEGLSALNILEARIDGMSSTEDGTVEIRLDCGGDIILSRITTLSCERLDLRQGRAIFAIIKTVALEA
What is the function of this protein?
Part of the ABC transporter complex ModABC involved in molybdenum import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Molybdenum import ATP-binding protein ModC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GSIC_ECOUT
Sequence: MLNYVIKRLLGLIPTLFIVSVLVFLFVHMLPGDPARLIAGPEADAQVIELVRQQLGLDQPLYHQFWHYISNAVQGDFGLSMVSRRPVADEIASRFMPTLWLTITSMVWAVIFGMAAGIIAAVWRNRWPDRLSMTIAVSGISFPAFALGMLLIQVFSVELGWLPTVGADSWQHYILPSLTLGAAVAAVMARFTRASFVDVLSEDYMRTARAKGVSETWVVLKHGLRNAMIPVVTMMGLQFGFLLGGSIVVEKVFNWPGLGRLLVDSVEMRDYPVIQAEILLFSLEFILINLVVDVLYAAINPAIRYK
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Glutathione transport system permease protein GsiC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARTA_ASPFN
Sequence: MGHEDAVYLAKLAEQAERYEEMVENMKVVASADVELTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNESQVTLIKEYRQKIESELAKICDDILEVLDKHLIPSAQSGESKVFYHKMKGDYHRYLAEFAIGDRRKGAADASLEAYKAATEVAQTDLAPTHPIRLGLALNFSVFYYEILNSPDQACHLAKLAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEPSRC
What is the function of this protein?
14-3-3 family protein that plays a role in the morphological differentiation and secondary metabolism biosynthesis (PubMed:29247055).  Required for normal fungal morphogenesis in an environment-dependent manner, affecting the balance between production of conidiophores and the formation of sclerotia, resistant structures that are necessary for the dissemination and survival (PubMed:29247055).  Acts as a positive regulator of conidiation and a negative regulator of sclerotial production (PubMed:29247055).  Regulates also the production of secondary metabolites such as aflatoxin, but also the indole-tetramic acid mycotoxin cyclopiazonic acid (CPA) and ustiloxin, an inhibitor of microtubule assembly (PubMed:29247055).
What are the official names of this protein?
14-3-3 family protein artA.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: PCMD1_BOVIN
Sequence: MGGAVSAGEDNDDLIDNLKEAQYIRTERVEQAFRAIDRGDYYLEGYRDNAYKDLAWKHGNIHLSAPCIYSEVMEALKLQPGLSFLNLGSGTGYLSTMVGLILGPFGINHGIELHSDVVEYAKEKLESFIKNSDSFDKFEFCEPAFVVGNCLQIASDSHQYDRIYCGAGVQKDHENYMKILLKVGGILVMPIEDQLTQIMRTGQNTWESKNILAVSFAPLVQPSKNDNGKPDSVGLPPCAVRNLQDLARIYIRRTLRNFINDEMQAKGIPQRAPPKRKRKRVKQRINTYVFVGNQLIPQPLDSEEDEKMEEDKEEEEKEPGEALKPEEPPQNLLREKIMKLPLPESLKAYLTYFREK
What is the function of this protein?
Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity.  May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Lipid-anchor.
Protein: CG121_ASHGO
Sequence: MLTTTIPQFPDTKLYISLFRNVSNAPEIVDSLAELPYSIIDARTLLSREQLLSAVYRAMLEKHCNKLRTRNLHTEVLLCLSPTSNVMSQIGDAMKRFGIKKDSTSVVLVKAVTGDETFDPKGFSEVIRGEELEFSDTALRESADIDTIRENYKLKCFECERLEELSAALVHAIQLRGL
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.  CGI121 is not required for tRNA modification (By similarity).
What are the official names of this protein?
EKC/KEOPS complex subunit CGI121.
What is the protein family that this protein belongs to?
Belongs to the CGI121/TPRKB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: TNF10_MOUSE
Sequence: MPSSGALKDLSFSQHFRMMVICIVLLQVLLQAVSVAVTYMYFTNEMKQLQDNYSKIGLACFSKTDEDFWDSTDGEILNRPCLQVKRQLYQLIEEVTLRTFQDTISTVPEKQLSTPPLPRGGRPQKVAAHITGITRRSNSALIPISKDGKTLGQKIESWESSRKGHSFLNHVLFRNGELVIEQEGLYYIYSQTYFRFQEAEDASKMVSKDKVRTKQLVQYIYKYTSYPDPIVLMKSARNSCWSRDAEYGLYSIYQGGLFELKKNDRIFVSVTNEHLMDLDQEASFFGAFLIN
What is the function of this protein?
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG.  Induces apoptosis.  Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Secreted. Note=Exists both as membrane- bound and soluble form.
Protein: GLMM_CLOBA
Sequence: MDRMFGTDGVRGIANTELTAQMAYNLGRAGAYVLTEGAHKPKILVAKDTRISGDMLESALVAGILSVGAEAVILGVVPTPAVAYLTREYNADAGVMISASHNPVEYNGIKFFNNKGYKLSDELEDGIQKVIESDFEGVPSPIGIDLGRERIEVAALEDYTEFAKQTIPYNLKGMKIALDCANGASYKSAVKAFRDLGADVFVINDNPDGTNINKNCGSTHPEELMDYVVKKGCDLGFAFDGDADRCLAVDENGKLINGDFILMLCANYLKEIGKLKDDTLVVTVMSNLGLDIACRGLGIKLEKTKVGDRYVLEEMTKDNYVLGGEQSGHVIFLDYNTTGDGLVTALQVASIVKKKEKTLSELCSVMKELPQVLVNATVPNDKKNIYLEDAEIVEAIKEIEAKLNGVGRVLIRPSGTEPLVRVMLEGENQVEIDEMAHGLANLILSKI
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: LORI_HUMAN
Sequence: MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK
What is the function of this protein?
Major keratinocyte cell envelope protein.
What are the official names of this protein?
Loricrin.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm.
Protein: ERPA_FRATW
Sequence: MSEVVQSVDPINFTEAASLKVKELIEEEGDNSLSLRVYITGGGCSGFQYAFAFDNEVKEDDMVITKNGVRLLVDSMSFQYLVGADVDYKDDVEGAYFVIRNPNAKTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: SELO_SALA4
Sequence: MTLSFTARWRDELPATYTALLPTPLKNARLIWYNDELAQQLAIPASLFDATNGAGVWGGETLLPGMSPVAQVYSGHQFGVWAGQLGDGRGILLGEQLLADGSTLDWHLKGAGLTPYSRMGDGRAVLRSTIRESLASEAMHYLGIPTTRALSIVASDTPVQRETQETGAMLMRLAQSHMRFGHFEHFYYRREPEKVQQLADFAIHHYWPQWQDVPEKYALWFEEVAARTGRLIAEWQTVGFSHGVMNTDNMSILGLTIDYGPFGFLDDYDPGFIGNHSDHQGRYRFDNQPSVALWNLQRLAQTLTPFIEIDALNRALDRYQDALLTHYGQRMRQKLGFFTEQKDDNALLNELFSLMAREGSDYTRTFRMLSHTEQQSASSPLRDTFIDRAAFDAWFDRYRARLRTEAVDDALRQQQMQRVNPAVVLRNWLAQRAIDAAEQGDMAELHRLHEVLRQPFTDRDDDYASRPPEWGKRLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: CLU_DROME
Sequence: MALETEAKNSNATATGDATATATKASGKAKENNNTAGGKKNLNPNSNQQNSNQNLVNGNGTAADGPAAKKKGKKNRNKSPTEPTTEAVLSNGHAEKPTVVDAVEDNADTNANVEKPQEGGAPDAEADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLDNVTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYLNTITQGDLLDKKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNVKNAKGPQALKVLTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYEEHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMFIWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHRHKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASKVNGAEKPDDKEKKNEEEEKKERSTSGEARAAAIVNAIREAQSNVATSNEVQAAEVVKRACAAVGSLKEKEFDFRFNPDVFSPGIRHADGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMPRMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTNGPVNPAVSSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSASDWTLMTPRSLWQQIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQVLLREYNFESKHKPTFGDDDIVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKMNDIYSSGKLTSDLPPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEKHFKTDSTENEVNDAINSIVAAANNNGEAEDAVSKDIKEQPEAGKQLTNGDKAAATEATSS
What is the function of this protein?
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
What are the official names of this protein?
Protein clueless, Clustered mitochondria protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CLU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALBA_NITMS
Sequence: MSTEARDTIFIGKKPLMAYVTSTLIQLANIPSVNIKARGLSIGRAVDVAQIIARKTENAGYSIGEIKIGSESLESQDGRTRNVSTIEIEVKRNQA
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
What are the official names of this protein?
DNA/RNA-binding protein Alba.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: SPEA_SHEWM
Sequence: MSNWSINDARTGYNVNYWSQGLYGISDEGEATVSPDPTRPECSIGLNELAKDMVKSGVNLPVLVRFPQILHHRVNSLCQAFNQAIQKYQYQADYLLVYPIKVNQQQTVVEEILASQVEKEVPQLGLEAGSKPELMAVLAMAQKASSVIICNGYKDIEYIRLALIGEKLGHKVYIVLEKLSELKTVLEESKKLGVTPRLGLRVRLAFQGKGKWQASGGEKSKFGLSASQVLTVIESLKSEEMLDSLQLLHFHLGSQIANIRDIRQGVSEAGRFYCELQKLGANVKCFDVGGGLAVDYDGTRSQSSSSMNYGLTEYANNIVSVLTDICNEYEQPMPRIISESGCYLTAHHAVLITDVIGTEAYKPEDIQPPAEDAPQLLHNMWHSWNEISGRADQRALIEIYHDCQSDLTEVHSLFALGQLSLTDRAWAEQVNLRVCHELQGVMSSKYRFHRPIIDELTEKLADKFFVNFSLFQSLPDAWGIDQVFPIMPLSGLDKAPERRAVMLDITCDSDGTIDQYVDGQGIETTLPVPAWSAESPYLIGFFLVGAYQEILGDMHNLFGDTNSAVIRLDDDGRTNIESVLAGDTVADVLRYVNLDAVSFMRTYEELVNKHIQEDERANILEELQLGLKGYTYLEDFS
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: LDH_STACT
Sequence: MKNIKANKVVLVGDGAVGSSYAFAMVAQGVADEFVIVDIAVDKVKGDVLDLNHGMPYGESPSIIKAGSYEDCSDADLVVITAGAPQKPGETRLDLVEKNTKIFKSIVGQIMDSGFDGIFLIAANPVDVLTYVTKKVSGLPKERVIGSGTILDTARFKYELGAEFGIAPESVNASIIGEHGDSELAVWSQTSIAGQNLYDILKSNPEKEKRIEEIFLNTRDAAYDIIQAKGATYYGIAMGLLHISKAILRNQNLVLTVSSYLEGEYGNEDVYIGVPTLVNRAGAVKIYETSLNEKETKEFNHSVEVLKDITKSVDKLFQ
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UXAC_FLAJ1
Sequence: MSANTFIHDNFLLENKYAEELYHNYSKNQPIIDYHNHLNPQFIAEDKIFDNITNVWINGDHYKWRAMRTLGIDEQFVTGNGSDKDKFLNWAKTVPYTMRNPLYHWTHLELARYFDIYDLLNEKSAEKIYTETTEKINSQAYSTQNLLKKVNAELVCTTEDPIDSLEFHKKFANNSTGIKMSTAFRPDKAILIANDGYNAYLDTLGDVSGVAINTFADLQAALRNRIEFFNANGCKLSDHGLDQIYFEDFTESEISSIFKKKRENRIITPEEALKFQSAVLIFLSETYHEFGWVQQFHLGALRNNNARMHRILGPDTGWDSIGDYPQAQKLSSFLNALDSKDKLTKTIIYNLNPADNEVMATMIGNFNDGSVRGKVQFGSGWWFLDQKDGMTKQLNALSNMGLISCFVGMLTDSRSFLSFPRHEYFRRILCNLLGDEIKRGELPNDMEWIGKLVADISYNNAKEYFKF
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: RUVA_AERHH
Sequence: MIGRLRGVVIEKQPPEVLLEVGGVGYEVQMPMSCFYDLPEIGKEATIHTHFVVREDAQLLYGFNHKQERALFRELIKTNGVGPKLALAILSGMTATQFVLSVEREEISSLVKLPGVGKKTAERLVVEMKDRLKGWVSHDLFSPAEITLPARESALRAPDSSEEAASALVALGYKPQQASQIVSKVAADGMSVEDIIREALRSLV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: OBG_ECOK1
Sequence: MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGTDPVENARIIISELEKYSQDLAAKPRWLVFNKIDLLDKVEAEEKAKAIAEALGWEDKYYLISAASGLGVKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQLEEIAEEDDEDWDDDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KC1E_MOUSE
Sequence: MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQQTGNTSPRAISRADRERKVSMRLHRGAPANVSSSDLTGRQEVSRLAASQTSVPFDHLGK
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity).  Participates in Wnt signaling (By similarity).  Phosphorylates DVL1 (By similarity).  Phosphorylates DVL2 (By similarity).  Phosphorylates NEDD9/HEF1 (PubMed:29191835).  Central component of the circadian clock (PubMed:18400165, PubMed:19414593, PubMed:21930935).  In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:18400165, PubMed:19414593, PubMed:21930935).  Controls PER1 and PER2 nuclear transport and degradation (PubMed:10848614, PubMed:14701732, PubMed:18400165, PubMed:19414593, PubMed:21930935).  Inhibits cytokine-induced granuloytic differentiation (By similarity).
What are the official names of this protein?
Casein kinase I isoform epsilon, CKI-epsilon, CKIe.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS3_NEOSM
Sequence: MGQKVNPVGFRLWTHGSHGSVWYSKSCDYAKTVAEDYFVTKYVESSFAHIGISKVIIKRKGASCDITLHCMKPGLIIGKKGADLESFRLKLNKKFGFVPSLNVVEVKKPNSSAVLVAKSIAFQLEKRSSFRRVIKKAIATVMRESDVKGVKVACSGRLSGAEIARTEVFKEGSIPLHTMRADIDYWVAEAHTTYGVIGVKVWIYRGNIFRV
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: NADK_RICPU
Sequence: MNINKIALIYNHNSKHLAIIEEIKKLYNYCKIEEAEVIIVIGGDGELLHNIHRYMHLNIPFYGVNLGNLGFLMNPLDTKKLLQNIHESTVSILNPLLMQVEDTSGQIYTALAINEVSIFRKTNQAAKFRIEVNGIERMSELVADGALVATPAGSSAYNLSASGPILPLESNMLCLTPICSFRPRRWHGALLLSSATIKFEILNTNKRPVNATADFQEFNNITNVTVKSTKDKPVKLLFNKNHTLEDRIIKEQFGG
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.