PharMolix/UniProtQA huggingface dataset:
Protein: LON_CHLAA
Sequence: MNDETLREQTTAESEETSPTTPSPEPEVVETLPLIPLEGAVVFPYIVVSLTLDELGSASAEAAAREGRQVLLAARRPDAPADAPITDQLFNVGVVARIEQLGTLPNGASGVVVRGLVRAVLGEAVQTTPYLRFRFTRRPDVFERTPELEQLMVEVHAAIDAVLELRPGVTQEIRNFVRSIDDPGHLADNTGYSPDYTFAERQELLETFDVSERLRKVLMFYRKQFALLEVQAKLRQEVQESAARQQREFYLRQQLRAIQKELGEDTSEAAELDDLRQKLAAADLPEVARKEADRELSRLARINASSPEYQMVRTYLEWLAELPWNKYTGQPIDIAFARQVLDEDHHGLQKVKERILEYLAVKQRRAALGEENLRANREPILAFVGPPGVGKTSLGQSIARALGRSFVRMSLGGVRDEAELRGFRRTYIGSQPGRIIQELRRAGTADPVILLDEIDKLGIDYRGDPAAALLEVLDPEQNHTFTDHYLNLPFDLSRVLFLATANTWDTVPPALRDRMEVIELSGYIEDEKVQIAQIHLVPRQLRANGLRPEEAVVTEDAIRCIINEYTREAGVRNLERSIGAVLRKVARRLSEGEIDPANTPFVVDAAFVRAALGRPRFTNETRERIDQPGVAIGLVWTPVGGDIIFVEASAVEGKKELTITGQLGEVMRESAEAALTYVRSRARSLGIEPDFFETHAIHIHVPAGAVPKDGPSAGITMATALASAATGRLVRDDIAMTGEISLRGRVLPIGGIKEKALGAHRAGIRTVILPRRNLIDLDDLPPAVSAEMTFIPVDTLDEVLSIALLPPATTTDTLTVAQRSDVLTPAS
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_ALTMD
Sequence: MAAKEVRFGDDARSKMLKGVNTLANAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAKEIELEDKFENMGAQMVKEVASKANDEAGDGTTTATVLAQAIVTEGLKSVAAGMNPMDLKRGIDKAVIAAVEELKALSTDCADSKSIAQVGTISANSDAEVGDIIAQAMEKVGKEGVITVEEGQALQNELDVVEGMQFDRGYLSPYFINNQENGTVELDNPFILLVDKKISNIRELLPTLEGVAKAGKPLMIIAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTVISEEIGLELEKVQLEDLGTAKRVVINKDNTTVVDGNGDQEAIEGRCAQIKGQIEESSSDYDKEKLQERLAKLSGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVPGGGVALVRAAAKLSELTGDNEDQTVGVKLALRAMEAPLRQISINSGAEASVVVNEVKNGDGNYGYNAGNDTYGDMLEMGILDPTKVTRSALQFASSIASLMITTEAMVAELPKDEAAPAMPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_ALKCK
Sequence: MNRRVARLRAVQTLYQLTLIDINVDKAIENTLNDEEEPSEFYNTLVHGTLEHQDEIDGYLSENLKGYTLDRLGHVDRAIARMGLFEMLYLDDIPVNVTLNEAIELAKAFGGTDAGRFINGVLSNSYDMAMKNK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PC23_PENCR
Sequence: YAFLLLHQHPDILDDLRTEHGQVCGLNRQSILLALQSRPRLLNDLKLTHAVLKETLRLFPMGPVLRKCPRVPSEMIEYEGRTYDIRNHIVAISHNSLHRRPDLFPDPDAFNPYRFLPGAVIPIPADAWRPFEKGNGYCVGQELAMIQMKVMLLLTLTEFDFQPKYARKAARGPDIYGGYAYTTGSGIGPTPAGGLPMRVDKRAK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:26213965).  The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (Probable).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase penC then forms 3-geranylgeranylindole (3-GGI) (Probable).  Epoxidation by the FAD-dependent monooxygenase penM leads to a epoxidized-GGI that is substrate of the terpene cyclase penB for cyclization to yield paspaline (Probable).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase penP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase penQ (PubMed:26213965).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase PC-15 which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase penD (Probable).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase PC-16 and the P. simplicissimum ptmI-ortholog not yet identified in P. crustosum, leads to the production of the prenylated form of penijanthine (Probable).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase PC-22 (Probable).  A series of oxidation steps involving 4 cytochrome P450 monooxygenases (PC-21, PC-05, PC-23, PC-20) and a FAD-dependent monooxygenase (PC-14) are required for the transformation of PC-M4 to penitrems A and E.  Synthesis of these final products is proposed to proceed via penitrems D and C (PC-21, PC-05, PC-14) and penitrems B and F (PC-21, PC-05, PC-14, PC-23) (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase PC-23, Penitrem biosynthesis cluster protein 23.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: TSAD_THERP
Sequence: MIILGIETSCDETAAAVVRDGRFVLSNIIRSQVDLHQRYGGVVPELASRRHVTSIVPVLDLALEQAGIGPSAIDAIAVTEGPGLAGSLLVGINVAKTLAFVWEKPLIPVNHLEGHIYANWLTLPGQDEVPEPTFPLVCLIVSGGHTELVLMRGHGDYVLLGRTLDDAAGEAFDKAARLLGLGFPGGPAIQKAAEQGRPGRFSLPRAWLGESYDFSFSGLKTALLRVLEQYQRRPARRVAAGQPFPEYVAPEYGPSVPIADLAAEFQAAVVEVLAEKTARAAREFGATMVLLAGGVAANAALRQRLREISPVPVRYPPPILCTDNAAMIAGAAYYLAQRGVRADLDLDVHAHLPLVTRTLLRAGEA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPRTL_ENTFA
Sequence: MTDQALQTLVEKISIVFFQKPFLHQATFNRRLKTTGGRYHLASHHLDFNPTVFLKYGQEELEKVIKHELCHYHLHLAGKGYQHKDKDFKELLAKTGGARYAPPLVERKKAVFHQYQCQSCGEVILRKRRIDTTRYVCGKCHGRLSWQAKKEQI
What are the official names of this protein?
Protein SprT-like.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD_GEOUR
Sequence: MASTEIMTINMGPQHPSTHGVLRLIVELDGEIIQKVTPHIGYLHRGIEKLSEHRTYHQTIPLTDRLDYLAPMSNNLGYVLAVEKLLGIDVPERAQVIRVIMAELTRLKSHLVWIACHALDIGAMTVFLYAFRERENIMDIYEMVSGARMTSNFFRVGGLSKDIPEGFTAAVREVLDTFPGHFDTYEGLLTKNTIWLQRTIGNGVISAEDAIDYGITGPALRGSGVDWDLRRDNPYSGYEKYDFKVPVGENCDTFDRYKVRLVEMRESVKIIRQALDSLKPGPVLADEPQICYPPKENVYNSIEGLIHHFKIASEGFSTPEGEVYQSVEAPKGELGYYLVSDGSTKPYRMRIRPPSFVNLQAIEKMAKGAMIADLVAVIGTLDIVLGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FAS2_ORYSJ
Sequence: MRGGTVQINWHEQQPVLTLDFHPVSRRLATGGSDHDIKIWVIASDDSDKKLPTATYHSSLSSHSSAVNVLRFSPSGENLASGADGGGIIIWKLHSTDDGEAWKVQKTLLFHHKDVLDLQWSQDGAFLVSASVDNSCIVWDAIKGSVQQKLEGHLHYVQGVAWDPLGQYIASLSSDRTCRIYANKPQGKSKNTDRMNFVCQHTLVKAEHQNHDESKPPVRAHLFHDETLPSFFRRLAWSPDGSFLVLPAGLCKYSSEVINTAYVMSRRDLSRPAIQLPGASKAIVAVRFCPVLFKLRGSQSDCFFKLPYRVIFAVATLNSLYVYDTESVAPILIHAGLHYAAITDIAWSSDAKYLAVSSRDCFCTIIEFENEELGLPYNLSGTKELDEGNTNCENMKPLKVDSMEIDAGSSKAKIKASSAAVEVTPSPPVLAQNNILMTKDVAEGNATSENDRPSAVDNMEVDVGENKAKMEVTPVAVQVTAPPVSTKNSASSKPTKKRITPIAIN
What is the function of this protein?
Component of the chromatin assembly factor complex (CAF-1) involved in chromatin assembly following DNA replication and DNA repair.  Required for several aspects of development, including apical meristem maintenance by regulating the durations of the S- and G2-phases of the cell cycle through its chromatin assembly activity (By similarity).
What are the official names of this protein?
Chromatin assembly factor 1 subunit FAS2 homolog, CAF-1 subunit FAS2 homolog, CAF-1 p60 homolog, Protein FASCIATA 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat HIR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RACX_BACSU
Sequence: MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSCPTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLHIVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAIKQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKSTVSTYLAYQS
What is the function of this protein?
Amino-acid racemase able to utilize a broad range of substrates.  Preferentially catalyzes the epimerization of LL-diaminopimelate, as well as the racemization of D-lysine, L-arginine, L-ornithine, L-lysine and D-arginine.  Has lower activity against D-ornithine, L-histidine, L-alanine, L-tyrosine, L-phenylalanine, L-serine, L-glutamine, L-methionine, L-asparagine and L-homoserine.  Has weak activity against L-norleucine, L-aminobutyric acid and L-norvaline.  Has no activity toward nine L-amino acids (Thr, Glu, Asp, Val, Leu, Ile, Trp, Cit and Aad) (PubMed:28894939).  D-amino acids might be used as components of peptidoglycan and/or be involved in peptidoglycan metabolism and remodeling (PubMed:8491712, PubMed:28894939).
What are the official names of this protein?
Broad specificity amino-acid racemase RacX.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: RS3_AKKM8
Sequence: MGQKVNPIGFRLAVNKDWRSKWYATGQDYATKLHEDLVMRKYIKEQLMSAAVSSIVIERAWNSVRITVHTARPGLVIGRKGEEIEKIRQYLQGLCGASTQVNIDIVEIRSPETDAQLIAENVAVQLERRVSFRRAMKRAVQVAMERGADGIRIRCAGRLGGADIARAEWYREGKVPLQTLRTPIDYGFAEARTLYGIIGVKCWVNKRDEVVSQQNSRPSGPRGPRRPRA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PSD3_SCHPO
Sequence: MPFTKSCRSANTLRKGIKNGKLILKIIVNDIDNVESCLSGDESNDSKKSSASFYMKLKYGSYRALADNILSTDENRKEDIAVFDVPLPNGLQIDTFTLCLYRKSKWKKQIVGEAYIGIQALLLSTNPDETCKYPVISPPSGRNKENQSPSHQICNLSLKWIIYDPEDADADSKTLAKAWLQQIKMNQTSIDPMSNISKSLKELEVDNVESDLEDSSFIAEPDSSIPPSESSVSISTDTGKETPPSKSKKSSNQPYVSIGEGNSDLLGFVFLEIISVSNLPPLKNVFRTGFDMDPFVITAFSKNIFRTKWLRHNLNPVYNEKFLFEVGAFESNYDLVFKVVDHDKMSLNDSIAVGSFNVQSIINSSAQVDPETGLYSFNIETSSPSQDTSSKAEDSPTVQKIADDFSSAVGKDLRTDIIEQIIPLTLCCKHDFSTPRDVKLSFKAMFFPIAALRQKFWRVMLAQYGDIEDGHIGKLGMYAVLDTLGSNIPNSMVDDIYTELSSKNHDDTSDSITVDEAVICLERLVDLVCHQDQQATQTPQSPSSNEESGPGTPTQTSDQYEDSEDSRNFPSKLYLVYLSNCPLCLKFKLSKVNQQKATVHLATCASHDWKRVDRLMMTSYVSLNQAQRRWFSKAFAKVVYGSSKVGSTSATTLVQNRQTGQIQEEKMNAYVRIGIRLLYRGIRNRRIEGSKVKKILRSLTLKQGMKYDSPISVKEIKPFIRFFDLNMNEVDMPVGGFKTFNEFFYRKLKPGSRPCAFPDNPDILVSPADSRIVAYECIEKATTYWIKGTEFTVERLLGYSNEAQRFVGGSICISRLAPQDYHRFHSPVNGCIGPITKIEGQYYTVNPMAIRSYLDVFGENVRVLIPIDSNEFGKVMLVAVGAMMVGSTVLTVDEGKIVQRSDELGYFKFGGSTVITLFEPNVTSFDEDLLRNSKTKIETLVKMGERIGQKIDPNKPTDAEDHSKSDS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).  Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity).  Together with psd1 and psd2, responsible for the majority of phosphatidylethanolamine synthesis (PubMed:19286980).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme 3.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Localizes at the barrier septum.
Protein: BETA_XANC5
Sequence: MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGRRYNWAYETEPEPYMDNRRMECGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSYRDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLFHAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYLVGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYIQYACTKPVSLYPALQWWNQPAIGAEWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVHAKSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDPYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSCAMGTDDMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRMRGRPPLPRSTADYYIAGDAPVRG
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: NOC_BACCZ
Sequence: MKNTFSRLFGFGDKESEFELQDESHEEIDKKVYEEIQEIPIVNITPNRYQPRTVFDDARIEELALTIRTHGLIQPIVVRQYEDDKYEIIAGERRFRAATKLGWEKVPAIIKNLNDTETASVALIENLQREELTAIEEAVAYQKLIELHNLTQEALAQRLGKGQSTIANKLRLLKLPEEIKNALLEKSITERHARALIPLKNEELQLKVLQEIVEKQLNVKQTEERITKLLEEAKPKRKAKQKAVSRDTRIAMNTIRQSLQMVADSGLNVNSEEEEFDEYYQITIQIPKKK
What is the function of this protein?
Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle.  It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.
What are the official names of this protein?
Nucleoid occlusion protein, Noc.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CYF_BRARR
Sequence: MQTRNTFSWIREEITRSISVSLMIYIITWASISSAYPIFAQQNYENPREATGRIVCANCHLASKPVDIEVPQAVLPDTVFEAVVKIPYDMQLKQVLANGKKGALNVGAVLILPEGFELAPPDRISPEMKEKIGNLSFQNYRPNKKNILVIGPVPGQKYSEITFPILAPDPATNKDVHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNATAGGIISKILRKEKGGYEITIVDASNERQVIDIIPRGLELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFLGSVVLAQIFLVLKKKQFEKVQLSEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single- pass membrane protein.
Protein: KHSE_XYLFM
Sequence: MNRTLQPDSGASQTAPTAHQARAFAPASVANVAVGFDLLGYPMDQVGDTVTVRRIDTPQVRIAAIRGIAQPLPLQTERNTAGAALLSMHRDLALPFGFELEIDKGIPLSSGMGGSAASCVAALLAANALLDEPLRREHLYRYALDGEAVASGSRHGDNLGPLFLGGLVLCTLERLVPVTVPTAWHSLLVHPDTLLETRRAREVLKEPYLLPDIVTQSANLALVLAGCYHSDAELVRAGLRDVLIEPRRAPLIAGFTAAQQAALQADAMGASISGAGPSVFAWFQTRSAAEAAAPAVRAAFTAAGFDSQAWVTPLTSPGARLL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HKM4_ASPHA
Sequence: MSIPSGTEPQIKRFSVTADPDTIFQAYQEDGVVIIQGFLSPEQLDKFNREVNPRLAHQRQGYQPSLKARLMEGSLSALLPPQQKRVHNLAGFSKVFRHDILNHGLMHELCRRAFAATGDYWLSSGAVIENGPGTPEQGWHRDQPSYPVIQAGPGTAEGMVNFFTALTDFTAEAGATQFMHGSHKVVGIPDGDPNHPMLIAEMKAGDSVLLSGKLVHRGGLNNTSDFFRRALSLAISPCVLTPYESSIHLSRPLVESMTPLAQRMIAWRSASIPPPYQIGMWTLNMNEVGEEMGLKYNQPYDEDEE
What is the function of this protein?
Dioxygenase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines (PubMed:33242032).  The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (Probable).  Xenocockiamide A is then converted to hancockiamide D via a series of hydroxylations and O-methylations (Probable).  The tyrosinase hkm6 may catalyze an aromatic hydroxylation, then the 2-oxoglutarate-dependent Fe(II) dioxygenase hkm4 and the FAD-dependent phenol hydroxylase hkm7 may catalyze consecutive hydroxylations to install 2 more hydroxy groups, and the methyltransferase hkm8 probably catalyzes two methylations using 2 molecules of S-adenosyl-L-methionine (SAM) (Probable).  The NRPS hkm11 activates and transfers trans-cinnamate supplied by the PAL hkm12 to hancockiamide D and produces hancockiamide A (PubMed:33242032).  NRPS Hkm11 has the flexibility to tolerate the bulky hancockiamide G as a substrate and the absence of the acetyl-transferase hkm3 opens up the opportunity for hkm11 to introduce a second N-cinnamoyl moiety (PubMed:33242032).  The cytochrome P450 monooxygenase hkm5 catalyzes the methylenedioxy bridge formation, converting hancockiamide A into hancockiamide G (PubMed:33242032).  Hkm5 can also convert hancockiamide B into hancockiamide C, and hancockiamide D into hancockiamide H (PubMed:33242032).  The N-acetyltransferase hkm3 finally transfers an acetyl group to 1-N of piperazine, converting hancockiamide A into hancockiamide B and hancockiamide G into hancockiamide C (PubMed:33242032).
What are the official names of this protein?
Dioxygenase hkm4, Hancockiamides biosynthesis cluster protein 4.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: EFTU2_BARQU
Sequence: MAKSKFERTKPHVNIGTIGHVDHGKTSLTAAITKYFGEFKAYDQIDAAPEERARGITISTAHVEYETEKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPAIVVFLNKVDQVDDAELLELVELEIRELLSKYDFPGDDIPIVKGSALAALEDKDKSIGEDAVRLLMSEVDNYIPTPERPIDQPFLLPIEDVFSISGRGTVVTGRVERGVIKVGEEIEIIGIRPTSKTTVTGVEMFRKLLDQGQAGDNIGALLRGVDREGIERGQVLAKPGSVTPHTRFKAEAYILTKDEGGRHTPFFTNYRPQFYFRTTDVTGIVTLPEGIEMVMPGDNVAMDVSLIVPIAMEEKLRFAIREGGRTVGAGIVSKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTG12_ARATH
Sequence: MLTTNTLAVLLLLFLSLCSGQSPPAPEPIAADGPSSPVNCLVSMLNVSDCFSYVQVGSNEIKPEAACCPELAGMVQSSPECVCNLYGGGASPRFGVKLDKQRAEQLSTICGVKAPSPSLCSVLGFPTISPAGSEDSSSGSEGSDKDKKNGAMTTKYCGVALNSLALLLLFTFLSLS
What is the function of this protein?
Probable lipid transfer protein.
What are the official names of this protein?
Non-specific lipid transfer protein GPI-anchored 12, AtLTPG-12, Protein LTP-GPI-ANCHORED 12, Xylogen-like protein 13, AtXYLP13, AtXYP11.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: FETP_BURM9
Sequence: MARMIHCAKLGKEAEGLDFPPLPGELGKRLYESVSKQAWQDWLKQQTMLINENRLNMADPRARQYLMKQTEKYFFGEGADQASGYVPPAQG
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: OTC_CHRVO
Sequence: MTSVRHYLQFSDLSPDEYHHLFERSRVLKRRQSAGELHRPLVGKVMSMVFEKNSTRTRVSFEAGMAQLGGHAMFLDTKSSQIGRGEPIEDTARVLSRMSDIIMIRTFEQGLVQRLAAHSRVPVINGLTNEYHPCQVLADIFTYVERHGSIKGKTVAWVGDGNNVCRTWLQAAAVLGFKLKVASPLGYELQTLDGRHYGSDVLEMTRDPARAVHGADIVTTDVFTSMGFEAEQAARREAFEGYQVTAELMKQAKPEALFMHCLPAHRGEEVAAEVIDGPQSVVWDEAENRMHVQKALIEYLLLGHRED
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSMA4_STAA3
Sequence: MAIVGTIIKIIKAIIDIFAK
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.  Stimulates the secretion of the chemotactic factor interleukin-8 (IL-8).  The ensuing activation process triggers an inflammatory response in the host, thus contributing greatly to virulence.  Also possesses hemolytic activity, which may contribute to the development of disease.
What are the official names of this protein?
Phenol-soluble modulin alpha 4 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: NAT9_CAEEL
Sequence: MKLNSNVKIVAKKCILVPYEPCHVAKYHKWMENEEIRRLTGSEQLSLDEEYEMQKTWRNDEDKLTFIVLEMNESGEEVDHMLGDVNLFISTSPSTENPSDDVITGEVEVMIAEPRGRGKGIGEEAVRVIIAWAYENLKIEQFCVKITDDNTPSLSLFKKKLGFKQIGYSTAFKEFTFELPKNRLISEFSSFLEKNAEIKEYK
What are the official names of this protein?
N-acetyltransferase 9-like protein.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. GNAT subfamily.