PharMolix/UniProtQA huggingface dataset:
Protein: FPG_DEIRA
Sequence: MPELPEVETTRRKIEPLLRGKTIERIVHDAPHRYRNTERAHGRQVRGLTRRGKYLLLHLAAADAAEDEPHDLELIVHLGMTGGFRLEEGPHTRVTFELGSGEKLYFNDPRRFGKVVAVAPGDYASMPTLAAMGPEPLSDDFTEAEFVALAARCGPVKPWLLSQKPVSGVGNIYADESLWHARLHPAQTRLNADEAGRLYRAIREVMAAAVDKGGSSLGNGVGNYRQHDGEGGGFQHSHHVYGRAGQPCDRCGTPIEKIVLGQRGTHFCPVCQPLRTDRSA
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: BMR1B_HUMAN
Sequence: MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
What is the function of this protein?
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.  Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.  Receptor for BMP7/OP-1 and GDF5.  Positively regulates chondrocyte differentiation through GDF5 interaction.
What are the official names of this protein?
Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ZRAB2_PONAB
Sequence: MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPESQVIGENTKQP
What is the function of this protein?
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts.  May interfere with constitutive 5'-splice site selection (By similarity).
What are the official names of this protein?
Zinc finger Ran-binding domain-containing protein 2, Zinc finger protein 265.
What is the protein family that this protein belongs to?
Belongs to the ZRANB2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIR2H_MYCTU
Sequence: MTRTRSGSLAAGGLNWASLPLKLFAGGNAKFWHPADIDFTRDRADWEKLSDDERDYATRLCTQFIAGEEAVTEDIQPFMSAMRAEGRLADEMYLTQFAFEEAKHTQVFRMWLDAVGISEDLHRYLDDLPAYRQIFYAELPECLNALSADPSPAAQVRASVTYNHIVEGMLALTGYYAWHKICVERAILPGMQELVRRIGDDERRHMAWGTFTCRRHVAADDANWTVFETRMNELIPLALRLIEEGFALYGDQPPFDLSKDDFLQYSTDKGMRRFGTISNARGRPVAEIDVDYSPAQLEDTFADEDRRTLAAASA
What is the function of this protein?
Probable oxidase that might be involved in lipid metabolism (PubMed:19321420).  Is not essential for the survival of M. tuberculosis in stress conditions (PubMed:36149732).
What are the official names of this protein?
R2-like ligand binding oxidase, MtR2lox, Ribonucleotide reductase R2 subunit homolog, Ribonucleotide reductase small subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family. R2-like ligand binding oxidase subfamily.
Protein: RIMP_THEAB
Sequence: MKEIVSKVKEIAESACKKYNLELFDIKYYNKSGKWFLEIVIDNPLDYVSTKDCENISREVEFQLDKLDIIPQRYYLTVSSPGLDRPLRSIDDFKRFINNKVKIKLENETIIGYIKDVKDSVIFLEENNKKIKEIKYNQIKKANLEIDI
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_POLBI
Sequence: MAPNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLATQILTGLLLAMHYTADTSLAFWSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFVIAGITIIHLTFLHESGSNNPLGISSNSDKIPFHPYYSLKDILGLALMFIPFLALALFSPNFLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILLLIPFLHKSKQRTMTFRPLSQILFWLLVANLLVLTWIGSQPVEHPFIIIGQVASFSYFNILLILFPMAGALENKMLNY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: QUEC_CHLPB
Sequence: MRAVVLISGGMDSLVVAAQARALGYELAAMHVNYGQRTWQKELTAFRRICSHYAIERKLEVDAAYLEHIGGSSLTDSSIPVEQADLQTVAIPSSYVPFRNASFLSMAVSWSEVIGAERIFIGAVEEDSSGYPDCRKIFYDAFNKVIELGTKPETTIEIRTPLIDLQKSEIVRKGVELDVPFFHSWSCYKSEGKACGLCDSCARRLRAFQLVGLDDPIDYEVRPDYI
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: HXB9_MOUSE
Sequence: MSISGTLSSYYVDSIISHESEDAPPAKFPSGQYANPRQPGHAEHLDFPSCSFQPKAPVFGASWAPLSPHASGSLPSVYHPYLQPQGAPAAESRYLRTWLEPAPRAEAAPGQGQAAVKAEPLLGAPGELLKQGTPEYSLETSAGREAVLSNQRAGYGDNKICEGSEDKERPDQTNPSANWLHARSSRKKRCPYTKYQTLELEKEFLFNMYLTRDRRHEVARLLNLSERQVKIWFQNRRMKMKKMNKEQGKE
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-B9, Homeobox protein Hox-2.5.
What is the protein family that this protein belongs to?
Belongs to the Abd-B homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NSCR_TRIEC
Sequence: MEKRGPKRRQQAAHLSCELCRERKVKCDKLDPCTNCSSAGVICVPVRRPRLPRGAHAQRLRRNSPEDPEAPIQIDIASPADAGTIADDDLKKRIRRLEALVDSMRSSSHISKQDQEAEDTIESTLNRIDDDSLLIKTPRVHPSDGGLRILGLSGSSSPETGWASILEDREISMQLCQVYLLNVDPVIKILHRPSVEKWMLQGQRYLGFPERHSAVESLGAAICYVAATSLTETQSWARFHATKSSIVARARRACETTLEKSSPLLSPVITTLQAFLLYLHESFIEQNVLIPLKTHQVARRSEDPSRAVWTLMAFAVRIAKALDLPRGAGDNFFGQQMRKRLWLAICLLDFQTSLSQPSEPLITVAEATSSFSPPKHINDSDFDPTTSHDVPDREGLTDTTFSLVSYHVQAAGRLLNFEPSVKDDGSRQQNVQHFEQRTLRLLLYCDPESTPYAWFTWHRIQCFVSGARLSAIRPLMHQHGDHPISILDTNEGTSILSLALNILEKVQLVHTDPRGEAFRWFVTVPWQPLAIAMSECYICQDIALVQRAWPIVEAAFQQHEATVSGSSKAISITLERLMCRVREKLSPSLGTSTSLTASPIFCATNTANTLSVPHTPPSRSSITSSGDLLGNWSWTTATELLRPGEDLALVTEAPISTSPQKIDPLLFSLDSQLLIAGQEQLVEADQSWAAWDEVIASLHDDETGRANMFLS
What is the function of this protein?
Transcription factor that specifically regulates the neosartoricin B biosynthesis gene cluster (PubMed:23758576).
What are the official names of this protein?
C6 finger domain transcription factor nscR, Neosartiricin B biosynthesis protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAPP_STRR6
Sequence: MSLQKLENSSNKSVVQEEVLILTELLEDITKNMLAPETFEKIIQLKELSTQEDYQGLNRLVTSLSNDEMVYISRYFSILPLLINISEDVDLAYEINHQNNIDQDYLGKLSTTIKLVAEKENAVEILEHLNVVPVLTAHPTQVQRKSMLDLTNHIHSLLRKYRDVKLGLINKDKWYNDLRRYIEIIMQTDMIREKKLKVTNEITNAMEYYNSSFLKAVPHLTTEYKRLAQAHGLNLKQAKPITMGMWIGGDRDGNPFVTAKTLKQSALTQCEVIMNYYDKKIYQLYREFSLSTSIVNVSKQVREMARQSKDNSIYREKELYRRALFDIQSKIQATKTYLIEDEEVGTRYETANDFYKDLIAIRDSLLENKGESLISGDFVELLQAVEIFGFYLASIDMRQDSSVYEACVAELLKSAGIHSRYSELSEEEKCDLLLKELEEDPRILSATHAEKSELLAKELAIFKTARVLKDKLGDDVIRQTIISHATSLSDMLELAILLKEVGLVDTERARVQIVPLFETIEDLDHSEETMRKYLSLSLAKKWIDSRNNYQEIMLGYSDSNKDGGYLSSCWTLYKAQQQLTAIGDEFGVKVTFFHGRGGTVGRGGGPTYEAITSQPLKSIKDRIRLTEQGEVIGNKYGNKDAAYYNLEMLVSAAINRMITQKKSDTNTPNRYEAIMDQVVDRSYDIYRDLVFGNEHFYDYFFESSPIKAISSFNIGSRPAARKTITEIGGLRAIPWVFSWSQSRVMFPGWYGVGSSFKEFINKNPENIAILRDMYQNWPFFQSLLSNVDMVLSKSNMNIAFEYAKLCEDEQVKAIYETILNEWQVTKNVILAIEGHDELLADNPYLKASLDYRMPYFNILNYIQLELIKRQRRGELSSDQERLIHITINGIATGLRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: SCONB_ASPOR
Sequence: MQSDDRSVREGSDSSQTFLMKMAQPTGELTHPSQQQQLQLQQQSFQSIFGGASDTTEEIDTETDSNHRRPHSFGAAATTPAKLANKNVAPFLVKHIPEQYGPLGSRRTDKLEDLSSPNSKFCYRHRPDLKCRRQADEPSMDKLQRELETLPPSDQQGIAHVWSLFSAAPAKHRKLILQGIMAQCCFPQLSFVSATVRDLIRIDFLTALPPEISFKILCYLDTTSLCKAAQVSSRWRALADDDVVWHRMCEQHIHRKCKKCGWGLPLLERKRLRESKREIELRATTWDVSGPAQNAGGAECSAPHADDVITQKRKADSSDDETAIVKRHCSSLDARPEPDEDYYTTRYRPWKEVYKDRFKVGTNWKYGRCSTKVFKGHTNGVMCLQFEDNILATGSYDATIKIWDTETGEELRTLRGHQSGIRCLQFDDTKLISGSMDRSLKVWNWRTGECISTYTGHRGGVIGLHFDATILASASVDKTVKIWNFEDKSTFLLRGHTDWVNAVRVDTTSRTVFSASDDCTVRLWDLDTKACLRTFHGHVGQVQQVVPLPREFEFEDHDAECDNDNMSTTSGDTESNSLQATLGLESNATETSVFGPSFDNGRPAPPRYIVTSALDSTIRLWETTTGRCLRTFFGHLEGVWALGADTLRIVSGAEDRMVKIWDPRTGKCERTFTGHSGPVTCIGLGDSRFATGSEDCEVRMYSFRN
What is the function of this protein?
Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
What are the official names of this protein?
Probable E3 ubiquitin ligase complex SCF subunit sconB, Sulfur controller B, Sulfur metabolite repression control protein B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MET30/SCONB/SCON-2 family.
Protein: AGRG1_GORGO
Sequence: MTAQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQTHRSSLHYKPTADLRISIENSEEALTVHAPFPAARPASQSFPDPRGLYHFCLYWNRHAGRLHLLYGKHDFLLSDKASSLLCFQHQEESLAQGPPLLATSVTSWWSPQNVSLPSAASFTFSFHSPPHTAAHNASVDMCELKRDLQLLSQFLKHPQKASRRPSAAPARQQLQSLESKLTSVRFTGDTVSFEEDRINATVWKLQPTAGLQDLHIHSRQEEEQSEILEYSVLLPRTLFQRTKGRRGEAEKRLLLVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVANLTEPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPGHWSSAGCETVRRETQTSCFCNHLTYFAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACIVTIAAYLCSRRKPRDYTIKVHMNLLLAVFLLDTSFLLSEPVALTGSEAGCRASAIFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVDNYGPIILAVHRTPEGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLRPHTQKWSHVLTLLGLSLVLGLPWALIFFSFASGTFQLVVLYLFSIITSFQGFLIFIWYWSMRLQARGGPSPLKSNSDSARLPISSGSTSSSRI
What is the function of this protein?
Receptor involved in cell adhesion and probably in cell-cell interactions.  Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells.  Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination.  Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12.  Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays an essential role in testis development.  Plays a critical role in tumourigenesis.
What are the official names of this protein?
Adhesion G-protein coupled receptor G1, G-protein coupled receptor 56.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [ADGRG1 N-terminal fragment]: Secreted. SUBCELLULAR LOCATION: [ADGRG1 C-terminal fragment]: Membrane raft. Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts.
Protein: AMPP2_TRIVH
Sequence: MASYSVTVSVAGTSINKYPAGSAGFDLAMADSYDPGKQHARRVAAYLPKQQGLIYLPGQQTVLSEDSDQDRPFKQRRYFFYVTGVVEPDCHVTYDIAEDKLTLYVPDFDFKRTIWTGPTLGKDEANQRYDVDRVEYFSALEGDVLRWSQANPSLSIYILHPDQRPVTPLTVAYFYESKSLKHAMDACRVIKDEHEIQLIQRANRVSGAAHRSILANLHHFKNEAQIAGLFIDVCLSLRSKGTAYQTIAGSGSNGATLHYTRNNEPLAGRQMVVLDAGAEWSCYASDVTRSFPIPSSVSGGRDWPSREAEQIYAIVQRMQEECISRVKEGALFFSIHQHAHAIALEELLKLGILRIPQGSTKADLIKAEVTALFFPHGLGHHLGLEVHDVSPDSGTIPVELAIEREKGLMSVTEHRPPCTLSAPPLASGMVITVEPGLYFNRLAIDQARAERDEPNSKGRFVNFDVVERYVDVGGVRIEDDVLVTKDGNKNLTDAPKGKEMLDLIYGR
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase TRV_02643, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: SECA_MICLC
Sequence: MPSIIDRVLKISDNRVLKRMQATVDAVNLLEDDFRALSDAELRAETDTLRARHADGESLDLLLPEAFAAVREAAGRTLGQRHYDVQLLGGIALHQGNIAEMKTGEGKTLVATAPAYLNALSGRGVHVVTVNDFLASYQADLMGRVFRFLGMQTGVIVAGQTPAVRREQYAADITYGTNNEFGFDFLRDNMAWSLDELVQREHHYAIVDEVDSILIDEARTPLIISGPAQGEANRWYGEFARLVRRLEADTDYEVDHKKRTVGILGPGIEKVEDHLGITNLYETQNTTLIQFLNNAVKAKELFKRDKDYVVLDGEVQIVDEHTGRVLKGRRYNEGLHQAIEAKEGVEVKPENQTLATVTLQNYFRGYEKLAGMTGTAETEAAEFTSTYGLGVVVIPPNRERQRVDRNDVVYKNEKVKFDAVVDDIAERHAKGQPVLVGTTSVEKSEYLSTLLAKRGIRHEVLNAKNHAREAAIVAQAGRPGAVTVATNMAGRGTDIMLGGNAEFTAVARMQELGLDAAEDPEAYEARWPEVLAQAEAAVEDAHREVIEAGGLYVVGTERHDSRRIDNQLRGRSGRQGDPGESRFYLSLTDELMRNFNPGVAQRIMNSPSIPDDMALEFGFVSKAIQNAQAQVEGRNAEQRKNVLKYDDVMNRQREAIYTDRRSILEGEDLQDRVRRFVEDAVGNIVDAATEEGQATDWDLDQLWRDLAELYPVGISQEDVLDEVGGRGRLKAEVLKRELVSDALLAYEDREAQVGSEALREAERRVVLASIGRHWQEHLYEMDYLKEGIGLRAMAQREPLVEYQREGYTMFQNMLAGIREDAVRTLFQAQISAAPAPTSLPGVKDARAVTMAPQISVEGIDAPQRPAQLRFTGPSEDGQSAVTRSGTDSGATVAAGTNRRSRRQAERRGRRG
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: PSAI_GOSHI
Sequence: MTTFSSFPSIFVPLVGLVFPAIAMASLSLYVQKTKIF
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ILVD_ALIF1
Sequence: MPTYRSATTTHGRNMAGARALWRATGVKEDDFGKPIIAVVNSFTQFVPGHVHLKDMGQLVAGEIEKAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMMMAAMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPTVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSMLATHADREQLFINAGKRIVELTKRYYEQDDESALPRNIADRAAFENAMALDIAMGGSSNTVLHLLASAQEGEIDFDMGDIDEMSRRVPHLCKVAPSTPKYHMEDVHRAGGVMAILGELDRAGLLNNQTKTVLGLTMQEQLAQYDIMQTEDEEILKFFRAGPAGIRTTKAFSQDCRWDRLDDDRKEGCIRTKENAFSQEGGLAVLSGNIAVDGCIVKTAGVDEENLKFQGPAIVFESQDSAVEGILGGKVKAGEVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAASGGTIGLVNDGDIITIDIPSRSITLDVPESELQARRAKQDELGWKPVNRQREVSFALKAYASMATSADKGAVRDKSKLEG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SMCO4_TAEGU
Sequence: MRQLRGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLLIVVFVYVATRPNTTE
What are the official names of this protein?
Single-pass membrane and coiled-coil domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the SMCO4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: APT_TRIV2
Sequence: MDLKSLIRDIPDFPKPGILFRDITTLLRDRQGLRYTIDFLAEKCFEANLDIDYVIGMESRGFIFGTPLAYKLGAGFIPVRKKGKLPAAVHSIEYELEYGTDCLEVHRDALHPDSRVLIVDDLIATGGTASATAKLVQQIGCELVGFGFIIELRDLQGRKHLPDVPIISLVEY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_BRASB
Sequence: MSVTAERKAEIIKANATKAGDTGSPEVQVAILSERINNLTSHFKTHGKDNHSRRGLLKLVSTRRSLLDYLKKNDEARYKALLEKHNIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: MURG_SALPB
Sequence: MSGQPKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIDIDFIRISGLRGKGVKALLAAPLRIFNAWRQARAIMKRFKPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNQWLAKIATTVMQAFPGAFPNAEVVGNPVRTDVLALPLPQVRLAGRDGPIRVLVVGGSQGARVLNQTMPQVAARLGDTVTIWHQSGKGAQLTVEQAYAGAGQPQHKVTEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPAIFVPFQHKDRQQYWNALPLENAGAAKIFEQPQFTVEAVADTLAGWSREALLTMAERARAVSIPDATERVASEVSRVART
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VATG_YEAST
Sequence: MSQKNGIATLLQAEKEAHEIVSKARKYRQDKLKQAKTDAAKEIDSYKIQKDKELKEFEQKNAGGVGELEKKAEAGVQGELAEIKKIAEKKKDDVVKILIETVIKPSAEVHINAL
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:7775427).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:7775427).
What are the official names of this protein?
V-type proton ATPase subunit G, V-ATPase subunit G, V-ATPase 13 kDa subunit, Vacuolar proton pump subunit G.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase G subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DNAK_PASMU
Sequence: MGKIIGIDLGTTNSCVAVMDGDKPRVIENAEGDRTTPSIIAYTQDNETLVGQPAKRQAVTNPKNTLFAIKRLIGRRFQDEEVQRDVSIMPFEIVAADNGDAWVGVKGEKMAPPQISAEVLKKMKKTAEDFLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKGQGNKTIAVYDLGGGTFDLSIIEIDEVGGEKTFEVLSTNGDTHLGGEDFDNRVINYLVDEFKKEQGVDLRNDPLAMQRLKEAGEKAKIELSSAQQTDVNLPYITADATGPKHLNIKLTRAKLESLVEDLVSRSLEPVKIALADAGLSVSQIDDVILVGGQTRMPLVQQKVEAFFGKAPRKDVNPDEAVAIGAAVQGGVLAGDVKDVLLLDVTPLSLGIETMGGVMTTLIEKNTTIPTKKSQVFSTAEDNQSAVTIHVLQGERKRAADNKSLGQFNLEGINPAPRGMPQIEVTFDIDADGIIHVSAKDKGTNKEQKITIKASSGLTDEEIQQMVRDAEANAEADRKFEELVQARNQADHLVHGTRKQLSEVGDKLSAEDKAPIEKAVADLEAAAKGEDKAEIETKVQALIQVSEKLMQAAQPQPEAQAQQAQSGKSNDDVVDAEFEEVKDNK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CXCR4_SAISC
Sequence: MEGISIYTSDNYTEEMGSGDYDSIKEPCFREENAHFNRIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGKFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIRQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
What is the function of this protein?
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation.  Involved in the AKT signaling cascade (By similarity).  Plays a role in regulation of cell migration, e. g.  during wound healing.  Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels.  Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).  Involved in hematopoiesis and in cardiac ventricular septum formation.  Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells.  Involved in cerebellar development.  In the CNS, could mediate hippocampal-neuron survival (By similarity).
What are the official names of this protein?
C-X-C chemokine receptor type 4, CXC-R4, CXCR-4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).