PharMolix/UniProtQA huggingface dataset:
Protein: ANGP1_MOUSE
Sequence: MTVFLSFAFFAAILTHIGCSNQRRNPENGGRRYNRIQHGQCAYTFILPEHDGNCRESATEQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVSRQTFIIQELEKQLSRATNNNSILQKQQLELMDTVHNLISLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYFNNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
What is the function of this protein?
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation.  Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence.  Required for normal angiogenesis and heart development during embryogenesis.  After birth, activates or inhibits angiogenesis, depending on the context.  Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts.  In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades.  In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis.  Mediates blood vessel maturation/stability.  Implicated in endothelial developmental processes later and distinct from that of VEGF.  Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme (By similarity).
What are the official names of this protein?
Angiopoietin-1, ANG-1.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK_BORBU
Sequence: MLLQKTLCIVKPDGVRRGLIGDVVSRFERVGLKMVAAKMLIVDESLAKKHYLYDDIVFRHSEAVWNSLIKFISNSPVFTFVVEGVESIEVVRKLCGATEPKLAIPGTIRGDFSYHSFKYSNEKGFSIYNVIHASANEADAMREIPIWFKDNEILNYKRDDECEHYYC
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_POLOR
Sequence: MAHPTQLGLQDASSPIMEELLLFHDHALMTVFLISTLVLYIIMTAVSTKLTNKHLLDAQEIEIVWTVMPALVLIAIALPSLRILYLMDEINDPHLTIKATGHQWYWSYEYTDYDTLNFDSYMIPTQDLLPGQFRLLDTDNRMVVPTGSPVRMLITAEDVLHSWAVPSLGLKMDAVPGRLNQTTFIATRPGVFFGQCSEICGANHSFMPITIESAPVKYFESWSSSMLAES
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HFQ_CAUSK
Sequence: MSTEKKQNLQDTFLNSVRKSKTPLTIFLVNGVKLQGVVSWFDNFCVLLRRDGQSQLVYKHAISTIMPAQPVQLYEPSADQDD
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: FABZ_STAES
Sequence: METIFDYNQIKQIIPHRQPFLLIDKIVEYEEGKRCVGLKQVSGNEPFFQGHFPNYAVMPGVLITEALAQTGAVAMLNSEENKGKIALFAGIDKCRFKKQVVPGDTLMLEVEITKIKGPIGKGSAKATVDGQLACSCELTFAIQDA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_MYCGA
Sequence: MAKTKKHLLTQEGLKKLQAELRLLVDVKRADVIKLIQEAREQGDLSENADYDSAKATQSEIESRITEIQDILNHYEIIKEVDTKNKRVIVGAKVTIHDHSDECNYTYEIVGPIESDPAENKISHESPVAKAIMDKKEGESAEVIGIEHPYKVTIKKIVL
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RXL7_STAAE
Sequence: MSKEKVARFNKQHFVVGLKETLKALKKDQVTSLIIAEDVEVYLMTRVLSQINQKNIPVSFFKSKHALGKHVGINVNATIVALIK
What are the official names of this protein?
Putative ribosomal protein L7Ae-like.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
Protein: CAPSH_ADE31
Sequence: FDIRGVLDGPSFKPYSGSAYNSLAPKAAPNASQWLTTNNGNKTHTFAQAPYIGDSISKDGIQVGTNTANPQQAVYADKTYQPEPQVGESQWNASVSNNAKAAGRVLKSTTPMYPCYGSYARATNEKGGQSKNNDGVEMRFFASSANDNQNDPTVVMYSEDVNLEAPDTHIVYKPAVTADTISSELLHGQQAAPNRPNYIAFRDNFYWALYYNSTGNMGVLAGQASQLNAVVDLQDRNTELSYQLMLDALGDRSRYFSMWNSAVDSYDPDVRIIENHGVEDELPNYCFPLGAVGVVNSYKGVKQNDGNGWVKDDSVADTNDIAKGNIFAMEINLQANLWRSFLYSNVGLYLPDDLKYTPGNIKLPENKNTYEYMNGRVTVPGLVDTYVNIGARWYPDVMDNINPFNHHRNAGLRYRSMLLGNGRFVPFHIQVPQKFFAIKNLLLLPGSYTYEWNFRKDVNMILQSTLGN
What is the function of this protein?
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid.  Assembled into trimeric units with the help of the chaperone shutoff protein.  Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid.  Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus (By similarity).
What are the official names of this protein?
Hexon protein, CP-H, Protein II.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae hexon protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers (By similarity).
Protein: DBH_STAAN
Sequence: MNKTDLINAVAEQADLTKKEAGSAVDAVFESIQNSLAKGEKVQLIGFGNFEVRERAARKGRNPQTGKEIDIPASKVPAFKAGKALKDAVK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RS5_AZOC5
Sequence: MARDREHRAEREDRDNTFVDKLVHINRVAKVVKGGRRFGFAALVIVGDQKGRVGFGHGKAREVPEAIRKATESAKRALIRVPLREGRTLHHDVHGHHGAGKVILRAAPAGTGIIAGGPMRAVFETLGVHDVVAKSFGSSNPYNMVRATFDALTNQDSPRSVAARRGLKVSQLQSRRRVEDAEATD
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: GATA3_MOUSE
Sequence: MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTEEVDVLFNIDGQGNHVPSYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALSSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSGLSFGPHHPSSMVTAMG
What is the function of this protein?
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes.  Binds to the consensus sequence 5'-AGATAG-3'.  Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.  Positively regulates ASB2 expression (PubMed:31175139).  Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33.  Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
What are the official names of this protein?
Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: TMCAL_STRT1
Sequence: MTVTGIIAEFNPFHNGHKYLLDYAEGIKIVAMSGNFVQRGEPAIVDKWIRAQMALENGADLVVELPFFTAVQSADYFASGAVDILSRLGIDSLTFGTEEVLDYQTIADVYSEKSEEMEAFVESLPSDLSYPQKTQKMWEKFAGVDFTGNTPNHILGLAYAKACAGKGITLNPIQRQGAGYHSLDKKVSFASATSLRLHKEDSDFVDKFMPNSKLFQTSPQVSWDNYFQLLVYQILTNPDLTSVFQVNEEIASRLKAAVREISSVEELVDKVATKRYTKARVRRILTYILVGAVDNSLPKSIHVLGFSQKGQFHLKSVKKSVDIVARIGRKPWDMLTQQADNVYQLGNPELCEQNFGRVPIRVK
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_ACIB5
Sequence: MELTLGLVAIASAILIAFGALGTAIGFGLLGGRFLEAVARQPELAPQLQTRMFLIAGLLDAVPMIGVGIGLFFIFANPFVG
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MUTS2_STRS7
Sequence: MEKKILEQLEFEKVKEQFWPYLQTEQGQLELDLLEPIANKDKIQAYFTELEEMAAIFVEHHHFALGGLSDVSESMQRLDLEADLSIQELLVIKKLLQVSAEVCRFYADLENVDLVALKALFEKIESFPSLQGSLQAINDAGFVEGFASPELESIRRQISNKEHASRQLLQDILKKQAAYLSESLIASRNGRSVLPVKNTYRHKVAGVVHDMSASGSTVYIEPRALVSLNEELTQLQADERHEIGRILHELSEQLRPHSRSLRNNAWLLGHLDLVRAKYLYMQAKQATVPVISDDKSLQLLNARHPLIQNPVANDLHFANDLAVIVITGPNTGGKTIMLKTLGLAQVMAQSGLPILADKGSRVAVFNGIYADIGDEQSIEQSLSTFSSHMTHIVEILNQADSDSLILFDELGAGTDPQEGASLAMAILEQLRLTNIKTMATTHYPELKAYGIETAYVENASMAFDNVSLKPTYRFMQGVPGRSNAFDIARRLGLAEHIVKEAQAMTATDHDVNRIIEQLEQQTLESRKRLEHIKEVEQDNLKFNRAVKKLYNEFSHAKDKELEKAALEAREIVDIALAESDSILSQLHEKAELKPHEIIEAKHRLKQLAPEQSLSQNKVLKQAKKWRAPRVGDDIIVTAYGQRGTLLAQLKDKRWEAQVGLIKLTLKEDEFSLVKLKEEAQQPKKRAVKVVKKAATGKGPRARLDLRGKRYEEAMQELDAFIDQALLNNMSQVDIIHGIGTGVIREAVGKYLRRNKHVKSFGYAPQNAGGSGCTIANLG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: THII_PASMU
Sequence: MKFVIKLFPEIMIKSESVRKRFVKILTGNIRNILTKHDETIAVVRHWDYIEVRSKKEENRPHLIELLGRIPGIHHFLEVDEKPFTTIHDIFEQTLQDIGTSLENKTFCVRVRRKGKHTFNSLDVERYVGGGLNQHIPSAKVQLSKPDVTVRIDIENDNMMLIKARHVGIGGYPIGTQEDVLSLISGGFDSGVSSYMLIRRGSRVHYCFFNLGGAAHEIGVKQMAYHIWQRYSASHKVRFVAINFEGVVGEILEKVDNGQMGVVLKRMMVRAASRIAERFGIQAIVTGEALGQVSSQTLTNLRLIDEASESLVLRPLITHDKEQIIAMAKEIGTDDIAKSMPEFCGVISKNPTVKAIKAKIEQEERHFDFAVLESAVQNAQYLDIRQIAEQTEKEVVAVDTVAVLSAQDVILDIRSPEETDEKPLNMENVQLMPFYKLSSQFANLDQSKNYLLYCERGVMSKLQALYLKEQGFSNVKVFRQ
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_LEPBP
Sequence: MKEKEKIIVAMSGGVDSAVAAGLLMEAGYDVIGVNLRTWEYEAPACDTTKKSCCSPEDIRDARDVGLSLNIPFYVIKMEKVFGERVIDRFISDYKDGRTPNPCVECNTFVKFGALFEQAKKLGIDKIATGHYARVIEVDGRYAIRNAVDMKKNQTYYLYGLSQDNIKNTVFPLGEMDKSEVREIAKRMGLPVAEKPESQEICFIPENDYRSFLKKKGMEFTPGFFKLASGQIIGKHQGKEGFTIGQRKGLGIAWKNPLYVLSIEDDGTVVLGEEEETVSESFVLEEITYQALAPLALGQSMEMKVQIRYRSAPVHCKVTSLGETWKVNFLEDVKSVTPGQSATFYPTNGDYLFAGGIIQKGSITRKIKSNVEVQRESVPI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 4HYPE_PSEPK
Sequence: MKQIHVIDSHTGGEPTRLVMKGFPQLRGRSMAEQRDELRELHDRWRRACLLEPRGNDVLVGALYCPPVSADATCGVIFFNNAGYLNMCGHGTIGLVASLQHMGLITPGVHKIDTPVGQVSATLHEDGAITVANVPSYRYRQQVAVDVPGHGVVRGDIAWGGNWFFLVSEHGQRIELDNREALTEYTWAMLKALETQGVTGENGAPIDHIELFADDPNADSRNFVMCPGKAYDRSPCGTGTSAKLACLAADGKLAEGQTWVQASITGSQFHGRYARDGERIRPFITGRAYMTADSTLLIDEQDPFAWGI
What is the function of this protein?
Catalyzes the reversible epimerization of cis-4-hydroxy-D-proline (c4DHyp) to trans-4-hydroxy-L-proline (t4LHyp).  May be involved in a degradation pathway that allows P. putida strain KT2440 to grow on either epimer of 4-hydroxyproline, c4DHyp and t4LHyp, as the sole carbon and nitrogen source.  Does not exhibit measureable racemase activity in vitro with any of the 19 natural chiral amino acid enantiomers.
What are the official names of this protein?
4-hydroxyproline 2-epimerase, 4-hydroxyproline epimerase, 4Hyp 2-epimerase, 4HypE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: TM141_HUMAN
Sequence: MVNLGLSRVDDAVAAKHPGLGEYAACQSHAFMKGVFTFVTGTGMAFGLQMFIQRKFPYPLQWSLLVAVVAGSVVSYGVTRVESEKCNNLWLFLETGQLPKDRSTDQRS
What are the official names of this protein?
Transmembrane protein 141.
What is the protein family that this protein belongs to?
Belongs to the TMEM141 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YJIM_ECOLI
Sequence: MSLVTDLPAIFDQFSEARQTGFLTVMDLKERGIPLVGTYCTFMPQEIPMAAGAVVVSLCSTSDETIEEAEKDLPRNLCPLIKSSYGFGKTDKCPYFYFSDLVVGETTCDGKKKMYEYMAEFKPVHVMQLPNSVKDDASRALWKAEMLRLQKTVEERFGHEISEDALRDAIALKNRERRALANFYHLGQLNPPALSGSDILKVVYGATFRFDKEALINELDAMTARVRQQWEEGQRLDPRPRILITGCPIGGAAEKVVRAIEENGGWVVGYENCTGAKATEQCVAETGDVYDALADKYLAIGCSCVSPNDQRLKMLSQMVEEYQVDGVVDVILQACHTYAVESLAIKRHVRQQHNIPYIAIETDYSTSDVGQLSTRVAAFIEML
What are the official names of this protein?
Putative dehydratase subunit YjiM.
What is the protein family that this protein belongs to?
Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
Protein: NUOH_RICCK
Sequence: MTSLFFEYTFPLIIIALKVVAITVPLILCVAYLTYVERRVIGLMQLRRGPNVVGPFGLLQPIADAVKLLFKEPIIPTNSDRILFILAPMITFILSLIGWAVVPFAKGLVLADINVGVLYILAISSLSVYGIIIAGWASNSKYAFLGAIRSSAQMISYEVSMGLVIITVLLTTGTLNLSGIIEAQRTIPWWIDLMLLPMGVVFFISVLAETNRLPFDLPEAESELVAGYNVEYSSMGFALFFLGEYANMILVSAMTTTFFLGGYLPPFNISWLDCIPGFFWFAFKVGFLLFCFLWIRATLPRYRYDQLMRLGWKVLLPLTLFWVVLVSSVLMYTDHLPSV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MHAA_STRSJ
Sequence: MSALPSLRVPTLPVAFEAAARAAGDRIALEYGSSSITYRELDAAANRFARRLLREGVTPGSRVGLHMTRCLELYIAMIGLLKAGAVVVPLNPSHPVTVRRSVVREADLPLTLRDVPAGLSSVTVERDVHELLAAGADLDDTSPGLCTDPESTAFILFTSGSTGRPRGVRIAHRGIARVASYNGEVEVRPDDCFLQLAPYSFAASTTDIWLSLLHGARVVVLPSQLPSLPKLAHTIKEYGVTFLNLPGGLMNLLIDAHPEAFAKVRTVIVSGDFPSAPHLARVMKAVPGTVYNAFGCTENSALTAVHPMTPEDLQLGVVPIGLPLPGVGLHVLGEDMTPCAPGEVGEMHISGAGLAQGYLGLPEETAAKFPTVDGVRMLRTGDWARTTPAGEVVLVGRTDQMVKIRGFRVELREVELAADQSGLVEKAVVRAVDATDGQKELVLFCTTATGEAPSIEALLADLKSRLPDYMLPARVHHLAELPVNVNGKLDRMALREPRAVLVEPDGTAQQQPVVRDIIATTVTRLLAVVTGREPIGVSDSFLASGANSLQVIQLAASLHDVMGVDVRPEDIFQLDNAESLAGHIRALRQGHREVPA
What is the function of this protein?
Involved in the biosynthesis of the antitumor antibiotic sibiromycin (PubMed:19270142, PubMed:21612226).  Activates 4-methyl-3-hydroxyanthranilic acid (4-MHA or 3H4MAA), a precursor of the antitumor antibiotic sibiromycin, as adenylate (PubMed:21612226).  The activated substrate is then covalently tethered to the thiolation domain (PubMed:21612226).  4-MHA is the preferred substrate, but it can also use 3-hydroxyanthranilic acid (3HAA) and anthranilic acid (AA).  Has lower activity with 5-hydroxyanthranilic acid (5HAA) and 3,5-dihydroxy-4-methylanthranilic acid (3,5DH4MAA) (PubMed:21612226).
What are the official names of this protein?
3-hydroxy-4-methylanthranilate adenylyltransferase, 4-MHA-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CRTM_STAHJ
Sequence: MSTLEENYQYCHQIMKDYSKSFSYAFDMLPEQQRRAIWAIYAVCRIVDDSIDVHQDVEYLHKINRDVKAIEHQTTTTFESDDRIMTAFADAATHFQMNFQALYDLIDTVEADQHFEMFETDRGLLDYCYGVAGTVGVLLIPILATPPSDEAYEYGKQLGEALQLTNILRDVGEDYRNGRIYFSKARLNEFNVSIADEIERDQLSDNYIKIWEFYATLADNNYDMVLNHLDVYNEESRMIIELAAQVYRGILTEVRKADYSLKDRAYVSKWKKHKIYRNLKKKYKD
What is the function of this protein?
Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress.  Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C(30) carotenoid 4,4'-diapophytoene (dehydrosqualene).
What are the official names of this protein?
4,4'-diapophytoene synthase, DAP synthase, C30 carotenoid synthase, Dehydrosqualene synthase.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family. CrtM subfamily.
Protein: AMPA_ALKEH
Sequence: MDHTVKSKTADTVSSPCAVVGVFERRRLSPAAKAVDEASGGAITAALKRGDIEAKPGQTRLLTDLDNVKAARVLLVGLGVERDLDERTYRKAVTAAAQAAQDCGAGEATFYLPEVEVKTRDLAWRVQQLAIGVTGALYRFDDMKSEAETPRKPLKKLALGVADKAEAKVADEALAQGMAVGRGMSLARDLGNLPGNVCTPSYLADQAKALGKRFDKLKVQSLDRKDMKKLGMGALLAVAQGSQEEPRLIAMEWNGGKKDEQPYVLVGKGITFDTGGISLKPGAAMDEMKFDMCGAASVFGTLQAVAEMNLPINVVGVVPASDNMPDGKATRPGDIIQTLSGQTVEVLNTDAEGRLVLCDALTWSERFKPKEIVDIATLTGACIIALGHHRSAVLGNHPPLVKALQDAGETSGDKCWELPLDPEYDEQLKSNFADMANIGGRPAGTITAASFLARFTKRYQWAHLDIAGTAWLTGEQKGATGRPVPLLTRYLMDRAGA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTF3_CHABO
Sequence: IQSTSMDQGILTEDSMNSFIRTLIQGGIWKNKVPKQTARTKDGMQTTVKKTEAEADAMASKDTRLGFQPVVSVDAELLRQQRRFSSPRVLLSENTPLEPPPLYLTEEPMVLNRTSRRKREGKSHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRMGSS
What is the function of this protein?
Seems to promote the survival of visceral and proprioceptive sensory neurons.
What are the official names of this protein?
Neurotrophin-3, NT-3.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: MOAC_BORPA
Sequence: MSTTPTLSHLDESGQIRMVDVGHKTDTDRVAIARGSVRMNATAYGLLTQPGQGKGEVLNTARVAAVLAAKRCAELIPLCHSLPLAFVGIDFELDEAAYSVHIRATCRTQYKTGVEMEAMTACSVAALTIYDMCKAADKGIVIEQIRLQYKAGGKSGEWRND
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.