PharMolix/UniProtQA huggingface dataset:
Protein: CNSG_PENEN
Sequence: MESPQLPPSMKRPAIVYGDKTPTILETTLGHLLDELSDIHRDKAAVEFPWQSIRRTYSELAKTSKLVAISLLSAGLCHGDRIGILTGNRYEFLDVFLAAARIGCPAVILQSNMSPGEMKAAVLKSGTTGNPKAAVLTHRNVVNNSHFFSRACDFEQSDIICSPLPLCHSFGLVSAFLCSFMRGCLILFPTEKFSADAVVDVLQNRDVTVIYGVPTMFFAVLEKLQGRGHKPRSMVKAIAGGAPVPYALITQICQDMGVQYFLNGYGMTETSPATFISPLGLCSESSLRTIGKVLPHTNARIVDRWGRTVQQGEKGELCISGLPLQKGYWEDEEKTSEIMTRDADGVIWLHTGDEAIIGEDDHCTITGRIKDIIIRGGLNISPVEIEERLILHPFIQEASVVGLPDKTRGEIVGCFLKQYVDMQRPSDEAVRAWVRELLGWHKAPEAIFWIGDAGIGEDFPKTASGKHQKEKLKDIGTYLLA
What is the function of this protein?
Acyl-CoA ligase; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals (PubMed:25571861).  Communesins are biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks derived from L-tryptophan (PubMed:25571861).  The L-tryptophan decarboxylase cnsB converts L-tryptophan to tryptamine, whereas the tryptophan dimethylallyltransferase cnsF converts L-tryptophan to 4-dimethylallyl tryptophan which is further transformed to aurantioclavine by the aurantioclavine synthase cnsA, probably aided by the catalase cnsD (PubMed:25571861).  The cytochrome P450 monooxygenase cnsC catalyzes the heterodimeric coupling between the two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold (PubMed:26963294).  The O-methyltransferase cnsE then methylates the communesin scaffold to produce communesin K, the simplest characterized communesin that contains the heptacyclic core (PubMed:25571861).  The dioxygenase cnsJ converts communesin K into communesin I (PubMed:25571861).  Acylation to introduce the hexadienyl group at position N16 of communesin I by the acyltransferase cnsK leads to the production of communesin B.  The hexadienyl group is produced by the highly reducing polyketide synthase cnsI, before being hydrolytically removed from cnsI by the serine hydrolase cnsH, converted into hexadienyl-CoA by the CoA ligase cnsG, and then transferred to communesin I by cnsK (PubMed:25571861).  Surprisingly, cnsK may also be a promiscuous acyltransferase that can tolerate a range of acyl groups, including acetyl-, propionyl-, and butyryl-CoA, which lead to communesins A, G and H respectively (PubMed:25571861).  The roles of the alpha-ketoglutarate-dependent dioxygenases cnsM and cnsP have still to be determined (PubMed:25571861).
What are the official names of this protein?
Acyl-CoA ligase cnsG, Communesin biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: Y364_AQUAE
Sequence: MREIKTPKAPVPVGPYSQAVEVNGFLFISGQIGINPETGKLVEGFKEQVIQIFKNVDAILEEAGLKRENIVKVTIYITDIKKFKELNEIYEDYFKDVSVKPARVTVGVKELPLNAEVEIEIVAVK
What are the official names of this protein?
RutC family protein aq_364.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: MOAC_STRAW
Sequence: MTVPSRGETPGPPAQDRLTHIDEAGAARMVDVSGKDVTARTARASGRVLVSPRVVELLRGEGVPKGDALATARIAGIMGAKRTPDLIPLCHPLSVSGVKLDLSVADDAVEILATVKTTDRTGVEMEALTAVSVAALTVIDMVKAVDKGAVITDVRVEEKTGGKSGDWSRS
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: YBGE_SHIFL
Sequence: MSKIIATLYAVMDKRPLRALSFVMALLLAGCMFWDPSRFAAKTSELEIWHGLLLMWAVCAGVIHGVGFRPQKVLWQGIFCPLLADIVLIVGLIFFFF
What are the official names of this protein?
Uncharacterized protein YbgE.
Protein: SYV_STRA1
Sequence: MSKELSPKYNPAEVEAGRYQTWLDQDVFKPSGDAEAKPYSIVIPPPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLREQGISRYDLGREKFLDKVWEWKDEYAATIKSQWGKMGLSVDYSRERFTLDEGLSKAVRKVFVDLYNRGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVATTRPETMFGDVAVAVNPEDPRYKDLIGQNVILPIINKPIPIVADEHADPEFGTGVVKITPAHDPNDFAVGQRHNLPQVNVMNDDGTMNELADEFNGMDRFEARKAVVAKLESLGNLVKIEKMTHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDTFMSWMENVHDWVISRQLWWGHQIPAWYNVNGEMYVGEDAPEGDGWTQDEDVLDTWFSSALWPFSTMGWPDTEAADFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFSNVLIHGLIRDEEGRKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDASWNFINKIWNISRYILMNNEGLTLDQARENVEKVVNSQVGNVTDRWILHNLNETVGKVTENFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEDEKVVTRSVLLYTLDQILRLLHPIMPFVTEEIFGQYAEGSIVLASYPQVNATFENQTAHKGVESLKDLIRSVRNSRAEVNVAPSKPITILVKTSDSELESFFKDNSNYIKRFTNPETLEISSAITAPELAMTSIITGAEIFLPLADLLNVEEELARLEKELAKWQKELNMVGKKLSNERFVANAKPEVVQKEKDKQTDYQTKYDATIARIEEMKKINND
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_NEIMF
Sequence: MSKKIKVGIVGATGYTGVELLRLLAAHPDVEVAAVTSRSEAGTAVADYFPSLRGVYGLAFQTPDEAGLEQCDIVFFATPNGIAMKDAPRLIEQGVRVIDLSADFRIWDIPTWEHWYGMPHAAPGLVSQAVYGLSELNREAVAQARLVANPGCYPTCVSLPLVPLLRQCRLKPGMPLIADCKSGVSGAGRKGNVGSLLCEVGDNFKAYGIAGHRHLPEIRQTIAGLQDGIAEGFVFTPHLAPMIRGMHATVYLHLSDGICPETILRDYYRDSLFVDILPAGSTPETRSVRGANLCRISIQQAAQSDVWVVLSVIDNLVKGAAGQAVQNMNIMFGLKETHGLGAIPLLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_MYCS5
Sequence: MEKDNQPSIEELKAFLQKNNIEYKNIDLFIEATTHKTYSKVNKNSKDYERLEFLGDSLVGFLISDYCVREFSSLEPGELSRLRSKLVDKLALFKIAQKLKVEQIIKTGPKKARNEVLSSSNVLSDVVEALIAAIYLDQGMQSAKDFIKSHFYEIANKAQNKPNKDPKSELQEYFQTISAETVKYETIEIPNKRSFESKAWHLNKIYGTGVGLSKKDAEKNAAANALSKLKT
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_BRUSI
Sequence: MTAIIDIVGREILDSRGNPTVEVDVVLEDGSFGRAAVPSGASTGAHEAVELRDGGSRYLGKGVEKAVEVVNGKIFDAIAGMDAESQLLIDQTLIDLDGSANKGNLGANAILGVSLAVAKAAAQASGLPLYRYVGGTNAHVLPVPMMNIINGGAHADNPIDFQEFMILPVGATSIREAVRYGSEVFHTLKKRLKDAGHNTNVGDEGGFAPNLKNAQAALDFIMESIEKAGFKPGEDIALGLDCAATEFFKDGNYVYEGERKTRDPKAQAKYLAKLASDYSIVTIEDGMAEDDWEGWKYLTDLIGNKCQLVGDDLFVTNSARLRDGIRLGVANSILVKVNQIGSLSETLDAVETAHKAGYTAVMSHRSGETEDSTIADLAVATNCGQIKTGSLARSDRTAKYNQLIRIEEELGKQARYAGRSALKLL
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: AROE_GLOC7
Sequence: MPLITGKTKLLGVIGDPVEHSLSPVMHNAVIDHLNLNYIYVPFAVKPEDLRTAIAGLEAIGVVGFNLTIPHKQTIIPLLSTISETAQLVGAVNTVWRTETGWSGTNTDVHGFLAPLKRLNLPWSQVSPVILGNGGAARAVVVGCYEMGCRQISVVGRTKEKLDHFYQSWQNTPIQEALRVYLWEDLPQLVSKTQLLINTTPLGMSPHIDQSPVDLTVMKKLQPGAIAYDLIYTPNPTLFLKEAQQQGAIIIDGLEMLAQQGALALSIWIKQSVPVEIMSQSLRDYLNL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: CAS1B_THEYD
Sequence: MKKSLYIISDGELKRKDNTLYFETSEERKYIPVENTREILIFGEVSMNKRLLEFLTESEIIIHFFNYYGYYIGSFYPREHLNSGYMILKQAEHYLDTGKRLNLAEKFVSGAIENIKKVLIYYHNRGKELSEIISKIQEIATNIPDCSTTDELMAIEGNIRDYYYQSFDIILDNEHFIFETRTKRPPKNRINALISFANSLVYTTCLSEIYQTHLDPRIGYLHATNFRRFTLNLDVAEIFKPIIADRAIFSIVNKRIVKPQHFEKKLDGIVLNDKGKQILLQEMDERLRSTIQHKKLGRHVSYRQLIRLELYKIQKHLMEEEEYKPFVTGW
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endonuclease Cas1 2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endonuclease Cas1 family.
Protein: HM43_CAEEL
Sequence: MDPSKGFEYVAGDYYQTSGVAPPTSNGAGSNVSPYFPYHAYPTSSTNGATGGSMYGTPQQTSAYAMYPPGPGSSPEEAFPEHTTTKIVEGCEAKYNVKGKKMRKPRTIYNSSQLQMLQKKFQKTQYLALPDRAALAHELGLSQTQVKIWFQNRRSKQKKQKGGSSDHASDEEDDDTEESKPESPPMGESVMIQESSEPRTLVSSSIKTEMKEEYPPMTLNEQYASPYLYGSDFSTILPPSQGFPNNALYNTAGAYPSIDYTNGVYQNTLYKYV
What is the function of this protein?
Probable transcription factor (PubMed:23788625).  Binds to the sequence motif 5'-ATAAT-3' in regulatory elements (PubMed:23788625).  Required for development of the anterior hypodermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability (PubMed:11747075).  Modulates and maintains dopaminergic neuron differentiation (PubMed:23788625).  May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-40 and ceh-20 (PubMed:23788625).
What are the official names of this protein?
Homeobox protein ceh-43.
What is the protein family that this protein belongs to?
Belongs to the distal-less homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYSA_BURPS
Sequence: MGITVRNLHKRFGEFAALDDVSLDFPAGELVALLGPSGCGKTTLLRVIAGLEHADSGQVVLQGLDVASVGARERQVGFVFQHYALFRHMTVFENVAFGLRVKPRRERPSEAAIRAKVHELLSLVQLDWLAQRYPSELSGGQRQRIALARALAVEPKVLLLDEPFGALDAKVRKELRGWLRRLHDDLHISTIFVTHDQEEALEVADRIVVLNHGRVEQVGSPQAVYDHPRSAFVYEFLGAANRLDGTVSGNGFVAHGAAQAIAVDADFAGPARAYVRPHDLELAAPYARAQGIAADVRRVVRLGGSVRVELAARSGEVLEAELDRNAWRALALDVGDALTAVPRAVRVFPAR
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CYB_PARMI
Sequence: MALNLRKNHPLLKIINDSLIDLPTPSNISIWWNFGSLLGICLVTQIITGLLLAAHYTADTSLAFNSVAHMCRNVQFGWLIRNLHANGASLFFICIYLHIGRGFYYGSYLNKETWNIGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFVIAGLTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYSIKDILGFALMLISLATLALFSPNLLGDPENFTPANPLATPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLIPLLHTSKQRSMTFRPLSQILFWILVTDLLILTWVGSQPVEHPFIIIGQLASFLYFTIILVLFPIVGALENKLLNL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RNC_SYNC1
Sequence: MLEAKSAALLEDTIDYVFDNQALLLEALTHKSFSNEQNDRTEPDNERLEFLGDAVLGVVVSHYIFRTFPHLPEGELTRIRSEVVSEKGLTVIGKAICLGDYMRLGKGEERSGGRQKSSLLANTMEALLGAVFCDGGFDSVRRVIEALFIPHIQRAARRKTGVDYKTRLQERLQARFGDVPQYVLIHADGPPHQRSYSVEAHFRGSCIGQGQGRSKKSAEQAAAKQALEYLEE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBPC_FUSNN
Sequence: MSVNIKIENAQKRYGDNIIIENLSLDIKQGEFFTLLGPSGCGKTTLLRMIAGFNSIEKGNFYFNEKRINDLDPAKRNIGMVFQNYAIFPHLTVEQNVEFGLKNRKVSKEEMKIEIDKFLKLMQIDEYKDRMPERLSGGQQQRVALARALVIKPDVLLMDEPLSNLDAKLRVEMRTAIKEIQNSIGITTVYVTHDQEEAMAVSDRIAVMKDGEIQHLGQPKDIYQRPANLFVATFIGKTNVLKGNLNGSILKVAGKYEVSLNNIKDKNIKGNVVISIRPEEFVIDENQTKDGMRAFIDSSVFLGLNTHYFAHLESGEKIEIVQESKIDSIIPKGAEVYLKVKQDKINVFTEDGSRNILEGVNNDAIGVAYVK
What is the function of this protein?
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Fe(3+) ions import ATP-binding protein FbpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Z354A_HUMAN
Sequence: MAAGQREARPQVSLTFEDVAVLFTRDEWRKLAPSQRNLYRDVMLENYRNLVSLGLPFTKPKVISLLQQGEDPWEVEKDGSGVSSLGSKSSHKTTKSTQTQDSSFQGLILKRSNRNVPWDLKLEKPYIYEGRLEKKQDKKGSFQIVSATHKKIPTIERSHKNTELSQNFSPKSVLIRQQILPREKTPPKCEIQGNSLKQNSQLLNQPKITADKRYKCSLCEKTFINTSSLRKHEKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYICKECGKAFTLSTSLYKHLRTHTVEKSYRCKECGKSFSRRSGLFIHQKIHAEENPCKYNPGRKASSCSTSLSGCQRIHSRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYRCEECGISFGQSSALIQHRRIHTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKLFNHRSSLTNHYKIHIEEDP
What are the official names of this protein?
Zinc finger protein 354A, Transcription factor 17, TCF-17, Zinc finger protein eZNF.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATX3_CAEEL
Sequence: MSKDDPINSIFFEHQEAALCAQHALNMLLQDALYKWQDLRDLAIQMDKMEQQILGNANPTPGRSENMNESGYFSIQVLEKALETFSLKLTNIENPAMVDYKNNPLTARAYICNLREHWFVLRKFGNQWFELNSVNRGPKLLSDTYVSMFLHQVSSEGYSIFVVQGVLPRSDADDLISLCPVVPPKVTPKKEQKLEKVMTKFFNTVGKRLGGGSGAPPDSQEEKDLAIAFAMSMETKDGSEVSRSSAEIDEENLRKAIELSQAPGPSEPAEIPLLTRSRSSTPPGASEPFSNAEQQRRDRQKFLERFEKKKEERNDEK
What is the function of this protein?
Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway (PubMed:19545544, PubMed:17234717, PubMed:21317884).  Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan (PubMed:21317884).  Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci (PubMed:27669035).  Interacts with key regulators of transcription and represses transcription (By similarity).  Acts as a histone-binding protein that regulates transcription (By similarity).
What are the official names of this protein?
Ataxin-3 homolog, Machado-Joseph disease-like protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Localizes predominantly in the cytoplasm (PubMed:17234717). In the germline, following ionizing radiation-induced DNA damage, localizes to foci within nucleoli where it colocalizes with cdc-48.1 and/or cdc-48.2 and ufd-2, proteasome alpha subunit and ubiquitinated proteins (PubMed:27669035).
Protein: SYH_COREF
Sequence: MTDKNTRTEKIQPFSAPKGVPDYAPPRSAAFVAVRDAFITQAHLAGFEHIELPIFEETGLFARGVGESTDVVSKEMYTFADRGERSVTLRPEGTAGVMRAVIEHSLDRGQLPVKLNYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEIIALADRSYRSLGLTGFRLELTSLGDSNCRPAYRQKLQDFLLNLPLDEETRRRAEINPLRVLDDKRAEVREMTADAPLMLDHLDDGCRTHFETVTGLLDDMGVPYEINPRMVRGLDYYTKTTFEFIHDGLGAQSGIGGGGRYDGLMAQLGGQDLSGIGYGLGVDRTILALEAEGVTVGQERRVDVYGVPLGQAAKKAMAGIINDLRAAGISADMSYGDRGLKGAMKGADRSGSLYTLVLGENELDNGTVAVKDMRAHDQQDIALSEVVSALRAKLA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_CLOBK
Sequence: MAVKGFRPTTPTRREMTMCTFEEITTSTPEKSLLVSLKKSGGRNANGKITVRHIGGGAKRKYRVIDFKRNKDNISAKVVSIEYDPNRTAFIALVVYADGEKRYMIAPVGLKVGDTVVSGPESDIKVGNCLPIRNIPVGTVIHNIELAPGKGAQLVRSAGNSAQLMAKEGDYSQVRLPSGEVRYIRVECRATIGVVSNQTNEIVNIGKAGRKRHMGVRPTVRGSVMNPNDHPHGGGEGRSPIGHPSPRTPWGKPALGYKTRKNKKYSDRFIVKRRHDK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ATPB_TRIL1
Sequence: MSQNIGKISQVIGAVIDVEFEPGKLPEIYHALRVTNPAIDDRENNLVLEVAQHLGENSVRTIAMDSTDGLKRGQAVIDTGKQICAPVGRKTLGRIMNVIGEPVDEMGPIGNEKEYGIHREAPAFEDQSTKVEAFTTGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIMELINNIAKQHGGYSVFAGVGERTREGNDLWMEMKESGVLDKAALVYGQMNEPPGARARVALTALSVAEYFRDEENQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGELQERITSTKKGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLSRQIAELGIYPAVDPLDSTSRILDPQVIGEEHYAVARSVQYVLQKYKDLQDIIAILGMDELSEEDKLVVARARKIQRFLSQPFHVAEAFTGSPGKYVELKDTIKGFQEIVAGKHDNLPEQAFYMVGSIEEAIEKAAKLAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DNAJ_BACHK
Sequence: MSKRDYYEVLGLSKGASKDEIKKAYRRLAKKYHPDVSKEENAIEKFKEVQEAYEVLSDDQKRAQYDQFGHAGANQGFGGFGGGGDFGGGFGFEDIFSSFFGGGGGRRRDPNAPRQGADLQYQVTLEFEEAIFGKELNVEIPVEDPCDTCKGSGAKPGTSKETCKHCSGSGQVSVEQNTPFGRIVNRQACSHCSGTGQMIKEKCTTCHGSGKVRKRKKINVKIPAGIDNGQQIRVSGKGEAGVNGGPAGDLYVVVHVRSHEFFEREGDHIICEMPLTFAQMALGAEVEVPTVHGKVKLKIPAGTQTGTEFRLKGKGAPNVRGYGQGDQYVVVRVVVPTKLTSHQKDLLREFAGQEEQDDSLFGKLKRAFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL2_AOTNA
Sequence: MYRMQLLSCIALSLALITNSAPTSSSTKKTQLQLEHLLLDLQMLLNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRDTRDIISNINVLVLELKGSETTFTCEYDDDTATIIEFLNGWITFCQSIISTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YAFW_ECOLI
Sequence: MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYHNDLTCEADTLGSCGYVYIAIYPTQR
What is the function of this protein?
Antitoxin component of a type IV toxin-antitoxin (TA) system.  Antitoxin that counteracts the effect of cognate toxin YkfI (PubMed:14594833, PubMed:28257056).  It does not seem to bind to the cognate toxin but instead induces toxin loss by an unknown mechanism (PubMed:14594833).  Co-overexpression of toxin YkfI and antitoxin YafW leads to formation of elongated cells (PubMed:28257056).
What are the official names of this protein?
Antitoxin YafW.
What is the protein family that this protein belongs to?
Belongs to the CbeA/YafW/YfjZ antitoxin family.