PharMolix/UniProtQA huggingface dataset:
Protein: RL9_BIFLD
Sequence: MAETKVILTKTVSNLGHSGDVVDVKSGYARNYLFPQGLAFAWTKGAEAQIVAMKRARLAKAVATREDAVAAKAAIEGTTVEIAAKVSESGKLFGGISNEAIAVALSDKAAVNPKAIEVETIKTTGDFPAKVALHPEITASFFVKVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: KGUA_EHRCR
Sequence: MNDSLKSRGIMLVISSPSGGGKTTISHLLINELQNDLVRSISVTTREPRDGEINGKDYFFVTEPEFINLCNTNQMLEYAKVFGNYYGIPRKFVTDNIANGVSVLFSIDWQGAFKLIDIMREHVVSIFILPPSMEELQRRLYNRSGESDVINKRLGEAAFEISHCYRYDYVIVNHDIEQSVYQIKCIFTSEKLKTQRRVSLKQFIDNCIR
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPR37_RAT
Sequence: MPAPGAPLSRTSRLLLLLLFKVSVSAALSFVPEPRNGTCLGESCSPLIPRRSRDAGGPRNSARDALRVHVPREKLEAEVRGATSWDLPPPRGGDTGVIEEAAASGPLGPPTKPPGAWRWKGAQGKEPSGHLGRREPTDSQLFRQTSERGEMSSKRDEIPQGSQEHSVKTEPEPRDLFYWPRKTGQLQGSHYRPSAVHEGRTLAPPGRALPQNGSADDWVPDQGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGQAPAERCVIKISPDLPDTIYVLALTYDGARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKASTRGNKRQIHLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCRPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC
What is the function of this protein?
Receptor for the neuroprotective and glioprotective factor prosaposin.  Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity).
What are the official names of this protein?
Prosaposin receptor GPR37, G-protein coupled receptor 37, G-protein coupled receptor CNS1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYT_BORPE
Sequence: MVQITLPDGSQRQYPGPVTVAEVAQSIGAGLAKAALAGRVAFDGAEPRLVDTSFRIDNDAQLAIVTAKDADGLDLIRHSTAHLLAYAVKSLFPDAQVTIGPVIDNGFYYDFSYKRPFTPEDLQAIEKKMAELARKDEVVTREEWSRDEAVAYFKGIGEVYKAEIIASIPSNETLSLYREGDFIDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEMLQRIYGTAWASKDDQDAYLHMLEEAERRDHRKIGRELDLFHFQDEAPGLIFWHPKGWALWQQVEQYMRKVYQDNGYQEVKAPQILDLTLWKKTGHWDNYRENMFTTESENRVYGLKPMNCPGHVQIFNAGLHSYRELPLRYGEFGQCHRNEPSGSLHGMMRVRGFTQDDGHIFCTEDQLQDECAAFTALLQKVYKDFGFTEVLYKVATRPEKRIGSDEIWDKAETALMESLRRTGCEFEISPGEGAFYGPKVEYTLKDAIGRHWQCGTIQVDFSMPVRLGAEYVDQNDQRRPPVMLHRAILGSLERFIGMLIENHAGAMPPWLAPLQAVVCCISEHSAEYAAQITQSLKKQGFRVQADLRGEKITRKIREHSLQKIPYLLVVGDKEMQNGTVAVRGLGGLDLGVIALDDFIARLAEDISTRRNVTQLASAA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_SALRD
Sequence: MPSPLAPMAVFVDLDERSYTVHFDSLATVPSLLEDVGLAAGRCLLVTDENVARHYKTPLIEGLSNAGWTVRSLVLPPGEQTKSASCLHRIYDDALAWGIDRQTPVLALGGGVVGDLAGFAAATLLRGLPLVQLPTSLLAQVDASVGGKTAINHDTGKNLIGAFYQPELVCADPQTLDTLPMREYTSGMAEVIKHALIRAPDLFEALEDHLVPVMARKDREIVSSVIEDAVGVKADVVSADEREEGRRAILNFGHTFAHALERVAGYGAFTHGEAVAIGMRAGLYLSHQRHPEAVPRERLDHVIRAVPIESDPAEVPFPDLYAAMAADKKNEGGTIRFVLLEQLGQAYVTGDVTEADARHAWQFACSN
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRB_MYCTA
Sequence: MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_SORBI
Sequence: MEKFEGYSEKQKSRQHYFVYPLLFQEYIYAFAHDYGLNGSEPVEIFGCNNKKFSSILVKRLIIRMYQQNFWINSVNYPNQDRLFDHRNYFYSEFYSQILSEGFGIVVEIPLSLGQLSCPEEKEIPKFQNLQSIHSIFPFLEDKFLHLHYLSHIEIPYPIHLEILVQLLEYRIQDVPSLHLLRFFLHYYSNWNSLITSMKSIFLLKKENKRLFRFLYNSYVSEYEFFLLFLRKQSSCLRLTSSGTFLERIIFSGKMEHFGVMYPGFFRKTIWFFMDPLMHYVRYQGKAILASKGTLLLKKKWKSYLVNFSQYFFSFWTQPQRIRLNQLTNSCFDFLGYLSSVPINTLLVRNQMLENSFLIDTRMKKFDTTVPATPLVGSLSKAQFCTGSGHPISKPVWTDLSDWDILDRFGRICRNLFHYYSGSSKKQTLYRLKYILRLSCARTLARKHKSTVRTFMQRLGLVFLEEFFTEEEQVFSLMFTKTKTIHFSFHGSQSERIWYLDIIRINDLVNPLTLN
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACYP_PSEAE
Sequence: MARICLHAYVGGRVQGVGFRQATREEADRLELDGWVRNLDDGRVEVVWEGEEDRAKALERWLGRGPRHAEVSAVEVEQMPLQGIAGFVVRR
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: PROA_NEIG2
Sequence: MSNTQKQLALAKAAKKSVNTADAEEKNRALLAMADSLEAAAEDILAANRLDLKAAAGKIPDSMTDRLLLDGKRICAMADGIRAVAALPDPVGEILETSTLPNGLEIVKKRVAMGVIGIIYESRPNVTSDAAALALKSGSAVVLRSGKDAFQSARAIVAALKTGLAQTRIDPEAVQLIEDTGREGSYEMMRAKDYLDLLIPRGGAGLIRAVVENAVVPVIETGTGIVHIYIDKDADWDKALRIVYNAKTGRPSVCNSMEVLLVHEGIAADFLPKLERLLVRGRIEAGLPPVRFRLDPQAARYIGGEAAGADDFDTEFLDYILAVKTVASVEEAVGHIEARGTHHSDGIVTENRHAADYFTTHIDSAAVYINASTRFTDGGEFGLGCEMGISTQKLHARGPMGLKELTSYKYIVQGTGQVRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y954_FRATT
Sequence: MILTTADTLGKREIIEYKGLVTGIIVRTPTITQGILGGLKNIIGGKNTSYTNVCKEARLHAEQEMINQAKELGANAIVAIRYDSSSLGGNTSGTEVFCYGTAVVVR
What are the official names of this protein?
UPF0145 protein FTT_0954c.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: SMRC1_MOUSE
Sequence: MAATAGGGPGAAAGAVGAGGAAAASGLAVYRRKDGGPASKFWESPDTVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQEDAFGKHVTNPAFTKLPAKCFMDFKAGGTLCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYPSSQEDEEWLRPVMRRDKQVLVHWGFYPDSYDTWVHSNDVDAEIEDAPIPEKPWKVHVKWILDTDVFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANSRKRKPSPSPPPPTATESRKKSGKKGQASLYGKRRSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNPKKDSENTPVKGGTVADLDEQDEEAVTTGGKEDEDPSKGDPSRSVDPGEDNVTEQTNHIIIPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQMLNFPEKNKEKPIDLQNFGLRTDIYSKKTLAKSKGASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLAYQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGSEEEKMETDPDGQQPEKAENKVENESDEGDKIQDRENEKNTEKEQDSDVSEDVKPEEKENEENKELTDTCKERESDAGKKKVEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQMEQQQQHGQTPQQAHQHTGGPGMAPLGATGHPGMMPHQQPPPYPLMHHQMPPPHPPQPGQIPGPGSMMPGQPMPGRMIPAVAANIHPTGSGPTPPGMPPMPGNILGPRVPLTAPNGMYPPPPQQQQPPPPADGVPPPPAPGPPASATP
What is the function of this protein?
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).  Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.  May stimulate the ATPase activity of the catalytic subunit of the complex.  Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).  During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.  The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.  As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).  The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.  The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
What are the official names of this protein?
SWI/SNF complex subunit SMARCC1, BRG1-associated factor 155, SWI/SNF complex 155 kDa subunit, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1, SWI3-related protein, BAF155.
What is the protein family that this protein belongs to?
Belongs to the SMARCC family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CATD_RAT
Sequence: MQTPGVLLLILGLLDASSSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPRTKEPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNKVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFAKAATL
What is the function of this protein?
Acid protease active in intracellular protein breakdown.  Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
What are the official names of this protein?
Cathepsin D.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Lysosome. Melanosome. Secreted, extracellular space.
Protein: T11_TERAN
Sequence: MSCFPVLFVMMLLVSQSVWAFPGPETRDGSVQDAESRRVRSAEEDCCENPVCKHTPGCPKGS
What are the official names of this protein?
Teretoxin Tan1.1.
What is the protein family that this protein belongs to?
Belongs to the teretoxin A (TA) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y115_METJA
Sequence: MGWENAPSHICRGGDLRGLAFCCPPIKYCPIHKALAVLKMSPEEFIRIKEEFGKRTKLGLGENTCFGSLVWCCKITKPCPYRDYELAKNNISPDEYMELKKQLAEEIIRNSQFFKEAVEVFVKKGIPKDIAEKCILETGDLKKAYEMAIKMIDKD
What are the official names of this protein?
Uncharacterized protein MJ0115.
Protein: IFRH_NICGL
Sequence: MVASEKSKILIIGGTGYIGKYLVETSAKSGHPTFVLIRESTLKNPQKSKLIDTFKSYGVTLLFGDISNQESLLKAIKQVDVVISTVGGQQFADQVNIINAIKEAGNIKRFLPSEFGFDVDHAHAIEPAASLFALKVKIRRMIEAEGIPYTYVICNWFADFFLPNLGHLDAKTPPRDKVVIFGDGNPKAIYVKEEDIATYTIEAVDDPRTLNKTLHMRPPANILSFNEVVSLWEEKIGKTLEKIYLSEEDILEIVKEGPLPLRTNLAICHSVFVNGDSANFEVQPPTGVEATELYPKVKYTTVDEFYNKFV
What is the function of this protein?
NADPH-binding protein (PubMed:19011764).  Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (PubMed:19011764, PubMed:31276744).  Reductase involved in a late step of tobacco alkaloid biosynthesis (PubMed:19011764).  Triggers either the formation of a nicotinic acid-derived precursor or the final condensation reaction of tobacco alkaloids (PubMed:19011764).
What are the official names of this protein?
Isoflavone reductase homolog A622, NgA622.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBC23_CHICK
Sequence: MAEGDGAPPSSWEKDLAEALEEGGCDLETVRNIIQGRQLPADLRAKVWKIALNVVGKGDSLASWDGCLDLPEQSIIHKDCQELIDRLSVPEDEKSVLLLDIESVITFYCKSRNVKYSSCLGWIHLLRPLVHLRLPRSDLYNCFYAIMNKYIPRDCFLKGRPFHLFRLLLQYHEPELCSFLDTKKMTPDSYALNWLGSLFSYYCSTEVTQAIWDGYLQQADPFFIYFLMLIILVNAKDVILAQESEKEEMLKFLETSPANLEVEDIEDLFSLAQYYCSKTPASFRKDNHSLFGSSLLGLKDDDTDLSQALCLAVSVSEILQANQQQGEGVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIARGGFMALQQHLADINVEGPENGYGHWIASTSGSRSSINSSVDGDSPNGSSDGKGVKSLVNKMTVALKTKSVNVKEKVISFIENTSTPVDRHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDGIDSSSMSDDDRKEVVNIQTWINKPDVKYNFPCNEVKENGHMFPSHLLVTATNMYCLREIPSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSNTSGIEILAVERYLIPNAGDATKAIKQQIMKVLDALES
What is the function of this protein?
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking.  Involved in endosome-to-Golgi trafficking.  Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity).  Plays a role in brain development (By similarity).  May act as a general inhibitor of innate immunity signaling (By similarity).
What are the official names of this protein?
TBC1 domain family member 23.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network.
Protein: CENPS_CANAL
Sequence: MVKQQSKEEIALQLKSAVYLSVAKIVEAKLEDLNNDNAATTTTESNNKNNNNNMLIATPTFIAQLVELVYNQLINLGEDLELFCQHANRDIVEPSDLFMVTRKNPTLQQHLKDLLRQ
What is the function of this protein?
dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (By similarity).  FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity).  Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis.  Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity).
What are the official names of this protein?
Inner kinetochore subunit MHF1, CENP-S homolog, Constitutive centromere-associated network protein MHF1, MHF histone-fold complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
Protein: E1B55_ADECR
Sequence: MEQDSDLESGRATNQRPPRVRVRGAGVRGRGRVRRRALSEGQRRSLFRLDDLQLPDSLYVTRALQRDHALEMPRGQVDFSLIEAEERRAGPTDEWYFESVKTYRAKPGDDLQTLIKNYAKISLECGAVYEINSKIVVTGACYIIGNCAVLRANLPVGTAMFEVLNVDVIPSIGFMERIVFSNILFDCRSTTAVVCCISERNTLFHNCVFSGPHMLCLDIRAGAEVRGCHFVGAVCALRSKGLYSVRVRNSIFEKCAFGVVSGSKASISHSMFKDCACCIMLGGQGTIAHSHFMATTCTDTPMNLQLCTCEGNGSHVVPLGNIHFASNREAPWPTFNANVLVRVRLYMGRRRGVFHPKQSTFSMCVIAAPRGVVQRIYLFSVYDATCAILQLGEAGDAATERLCTCGMRHNTPSLRAAYVTDTRIDREINSQDTAEFFSSDEDNL
What is the function of this protein?
Plays a major role to prevent cellular inhibition of viral genome replication.  Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6.  This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM.  Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest.  E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain.  E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
What are the official names of this protein?
E1B 55 kDa protein, E1B-55K, E1B protein, large T-antigen, E1B-495R.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 55 kDa protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Colocalizes with host TP53 to host PML nuclear bodies. PML localization of E1B-55K is necessary for E1B-55K-dependent SUMOylation of TP53.
Protein: SP5G_STACT
Sequence: MKVTDVRLRKIQTDGRMKALVSITLDDAFVVHDLRVIEGNSGLFVAMPSKRTPDGEFRDIAHPINSDMRQEIQDAVMKVYDETDEVIPDKNAQPSSDSEDNGSEEEA
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: RS2_VIBPA
Sequence: MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNRVHIINLEKTVPMFNEALAELAKVGEKKGKVLFVGTKRAASEAVKEAAIASNQFYVNNRWLGGMLTNYKTVRQSIKRLKELEIQSQDGTFDKLTKKEALMRTREMEKLEKSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVYAVVDTNSNPDGVDYIIPGNDDAIRAVQLYLNAAASAVTEGRNKDVAVVAEKDGFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: LOX1_HORVU
Sequence: MLLGGLIDTLTGANKSARLKGTVVLMRKNVLDLNDFGATIIDGIGEFLGKGVTCQLISSTAVDQDNGGRGKVGAEAELEQWVTSLPSLTTGESKFGLTFDWEVEKLGVPGAIVVNNYHSSEFLLKTITLHDVPGRSGNLTFVANSWIYPAANYRYSRVFFANDTYLPSQMPAALKPYRDDELRNLRGDDQQGPYQEHDRIYRYDVYNDLGEGRPILGGNSDHPYPRRGRTERKPNASDPSLESRLSLLEQIYVPRDEKFGHLKTSDFLGYSIKAITQGILPAVRTYVDTTPGEFDSFQDIINLYEGGIKLPKVAALEELRKQFPLQLIKDLLPVGGDSLLKLPVPHIIQENKQAWRTDEEFAREVLAGVNPVMITRLTEFPPKSSLDPSKFGDHTSTITAEHIEKNLEGLTVQQALESNRLYILDHHDRFMPFLIDVNNLPGNFIYATRTLFFLRGDGRLTPLAIELSEPIIQGGLTTAKSKVYTPVPSGSVEGWVWELAKAYVAVNDSGWHQLVSHWLNTHAVMEPFVISTNRHLSVTHPVHKLLSPHYRDTMTINALARQTLINAGGIFEMTVFPGKFALGMSAVVYKDWKFTEQGLPDDLIKRGMAVEDPSSPYKVRLLVSDYPYAADGLAIWHAIEQYVSEYLAIYYPNDGVLQGDTEVQAWWKETREVGHGDLKDAPWWPKMQSVPELAKACTTIIWIGSALHAAVNFGQYPYAGFLPNRPTVSRRRMPEPGTEEYAELERDPERAFIHTITSQIQTIIGVSLLEVLSKHSSDELYLGQRDTPEWTSDPKALEVFKRFSDRLVEIESKVVGMNHDPELKNRNGPAKFPYMLLYPNTSDHKGAAAGLTAKGIPNSISI
What is the function of this protein?
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.  It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.
What are the official names of this protein?
Linoleate 9S-lipoxygenase 1, Lipoxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
Protein: ATPB_BUCAT
Sequence: MATGKIIQIIGAVVDVEFNQDSVPKIYNALEVKNKQYKLILEVQQQLGSGVVRTIAMGSSNGLKRGLIVTDLGHYIKVPVGEATLGRIINVLGETIDNKGALKNNQSDKIEYWEIHRSPPSYRDQASCREILETGIKVIDLICPFSKGGKVGLFGGAGVGKTVNMMELIRNIAVEHSGYSVFTGVGERTREGNDFYHEMNDSQVLDKVSLVYGQMNEPPGNRLRVAFTGLTIAEKFRDEGKDVLLFIDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGLLQERITSTKNGSITSVQAVYVPADDLTDPSPATTFAHLDSTVTLSRQIASLGIYPAIDPLNSTSRQLDPYIVGDEHYETALGVQSILQRYQELKDIIAILGMDELAEKDKLLVSRARKIQRFLSQPFFVAEVFTGFPGKYVSLKDNIRAFKGIIKGEFDDLPEQAFYMVGSIEEVIEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CAS2_THEMA
Sequence: MYVIMVYDVNEKRVAKILKIARKYLKWVQNSVLEGELSPGKYEKLKLEVSRLIDEKEDSVRFYVMDSQKVFNLETLGVEKGEDGFIF
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).  Functions as a ssRNA-specific endoribonuclease.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: RS8_STRP4
Sequence: MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIAEILKREGFVKNVEIIEDDKQGVIRVFLKYGSNGEKVITNLKRVSKPGLRVYKKREDLPKVLNGLGIAILSTSEGLLTDKEARQKNVGGEVIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RS18_UREU1
Sequence: MAKVINNRNRKPRKKVCILSAKGIEHVDYKDVELLQRFINNNNKIASRRVTGASARMQRRIANAIKRARFVGLLPYVKE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: HUTG_AERHH
Sequence: MDKFNPVDMSVWQGRQDPEDGELALRWHDKVQPWPQAGRAAPGVALVGFACDEGVRRNKGRVGAAGAPLAVRKLLANSAWHLGRPVYDRGDVNCEDGDLDAAHGRLAERVARLLDEGHFPLVLGGGHEVAFGSWSGLNRHLAGRGRVGIINFDAHFDLRMKLEQASSGTPFFQIAEQCAIQGTPFTYACLGVAETANTQALFARAEALGVWHVLDEAMTPAELPALLSGLDAFIARCDHLYLTIDLDVLPAAVMPGVSAPAARGVELAVIEPLIAHIRASGKLRLADLAEYNPSLDQDNRSARVAARLVHQLIK
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.