PharMolix/UniProtQA huggingface dataset:
Protein: CYB_ELANI
Sequence: MSNQHTLLMTNLLPVGSNISTWWNFGSMLLTCLALQTMTGFFLAIHYTANINLAFASVIHITRDIPYGWTMQSLHAIGASLFFICIYIHIARGLYYGLYMNKEVWLSGITLLFTLMATAFFGYVLPWGQMSFWAATVITNLLTAIPYLGTMLTTWLWGGFSINDPTLTRFFALHFILPFIIISLSSAHIMLLHTEGSNNPLGTNSDIDKIPFHPYHSNKDMLTATIMITMLFITLSFLPNLLNDPENFSKANPMITPQHIKPEWYFLFAYGILRSIPNKLGGTLALLTSVMILATTPFTHTSHIRSMTFRPMTQTLFWILIATLITITWTATKPVEPPFMFISQMASMIYFSFFFMNPLLGWTENKIMMNN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ARGJ_BARQU
Sequence: MALKISPLSPQNIQELPPLSGVRIATAEAGIRDKGRTDLLFIVFDAPTSVAGVFTRSKCPSASVDHCRASLSHGVARGVVVNSGNANAFTGRKGKQTADAILHAAASALKVKENEIFIASTGVIGEPLEASSIVNLLPSMAETAEEGNWLEAARAIMTTDTFPKLATRKFYCGGKTVTINGIAKGAGMIAPDMATMLSFVVSDAAISSDILQSMLSEAVQGSFNSITVDSDTSTSDTLMMFATGKVKGNFPCFTSKSDPCYEVFSRQLSALLHELALQVVCDGEGARHLIEVCVTGATTENAAKTIALSIANSPLVKTAIAGEDANWGRVVMAVGKAGVEVDRDLLTIWFGEHRLAINGERDPDYHEEAISAYMRGKHITIRVDIGLGSGKATVWSCDLTKEYVMINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INTB_ECOLI
Sequence: MHLLVHPNGSKYWRLQYRYEGKQKMLALGVYPEITLADARVRRDEARKLLANGVDPGDKKKNDKVEQSKARTFKEVAIEWHGTNKKWSEDHAHRVLKSLEDNLFAALGERNIAELKTRDLLAPIKAVEMSGRLEVAARLQQRTTAIMRYAVQSGLIDYNPAQEMAGAVASCNRQHRPALELKRIPELLTKIDSYTGRPLTRWAIELTLLIFIRSSELRFARWSEIDFEASIWTIPPEREPIPGVKHSHRGSKMRTTHLVPLSTQALAILKQIKQFYGAHDLIFIGDHDSHKPMSENTVNSALRVMGYDTKVEVCGHGFRTMACSSLVESGLWSRDAVERQMSHMARNSVRAAYIHKAEHLEERRLMLQWWADFLDVNRERFISPFEYAKINNPLKQ
What are the official names of this protein?
Putative protein IntB, Int(P4), Putative prophage P4 integrase.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: RL28_LACP7
Sequence: MAKCAICDKGAHFGKVVSHSRSQVSGRSNKMWKSNVKSVRIKVNGGTQKMYVCTSCLRDGKVERA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: YBEY_STRP2
Sequence: MYIEMVDETGQVSKEMLQQTQEILEFAAQKLGKEDKEMAVTFVTNERSHELNLEYRDTDRPTDVISLEYKPELEIAFDEEDLLENPELAEMMSEFDAYIGELFISIDKAHEQAEEYGHSFEREMGFLAVHGFLHINGYDHYTPEEEAEMFGLQEEILTAYGLTRQ
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_LEUCK
Sequence: MAVISMKELLEAGVHFGHQTRRWDPKMDEYIFTERNGIHIIDLQKTVKLVDEAYNFMRNASTDGANFLFVGTKKQASDAIAEEAARAGQYFINHRWLGGTLTNWNTIKTRIQRLKDLEAMAEDGTFEQLPKKEVVLLNKQREKLNKFLGGIKDMPGLPDVLFVVDPKKEEIAVKEANMLNIPVVAMIDTNANPEVVDVKIPANDDAIRAVRLITAKMADAIIEGRQGQDSAPEDAFVAGDENTESIEEIANIVEEGNN
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: COAE_STAS1
Sequence: MPKVIGLTGGIASGKSTVSELLSAHGFKIVDADIASRQAVEKGTKGLERVKESFGEQAIDENGEMNRAYVGEVVFNQPEKRLELNEIVHPIVREIMEKEKAQYLSEGYHVIMDIPLLFENNLQDTVDEVWLVYTSESIQIDRLMERNNISMEEAKARVYSQISIDKKRRMADHEIDNRDTKLELKQNLENLLLEEGYIESHSEDVL
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_ACICJ
Sequence: MARVKRGVTTHARHKKVLKQSKGFVGRSSTNYRIALERLEKALRYAYRDRRNKKREFRALWIQRINAAVREQGMTYSQFIAALKAANIELDRKVLAAMAFDDPAGFTAIVEAAKAVRG
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ADAM5_HUMAN
Sequence: MQTSILIKSSCRPQFQRRFHHRMQKQIQNIISILSSASVINSYDENDIRHSKPLLVQMDCNYNGYVAGIPNSLVTLSVCSGLRGTMQLKNISYGIEPMEAVSGFIHKIYEEKYADTNILLEENDTYTWFNSEYQVRKSSEKTDFIKLFPRYIEMHIVVDKNLFKPANMICRKSVGKECDFTEYCNGDLPYCLPDTYVRDGEYCDSGGAFCFQGKCRTFDKQCDDLIGRGSRGAPVFCYDEINTRGDNFGNCGTAHCLFQHILCGKLVCTWEHRDLISRPNLSVIYAHVRDQTCVSTYLPRRTPPPVNSPISITSYYSAEDRDETFVQDGSMCGPDMYCFEMHCKHVRFLMNLKLCDASNHCDRHGVCNNFNHCHCEKGYNPPYCQPKQGAFGSIDDGHLVPPTERSYMEEGR
What is the function of this protein?
This is a non catalytic metalloprotease-like protein.
What are the official names of this protein?
Putative disintegrin and metalloproteinase domain-containing protein 5, Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, tMDC II.
Protein: RL13A_LUPLU
Sequence: MVSGSGIAAKRVVVDARHHMLGRLASIVAKELLNGQKVVIVRSEEICISGGLVRQKMKYLRFLRKRMNTKPSHGPIHCAPSKIFWRTVRGMIPHKTKRGEHALARLKVYEGIPPPFDKQKRLVVPDALKVLRLQKGHKYCLLGQLSSEVGWNYYDTIKELEKKRKERSQVVYERKKQLNKLRVKAEQVAQEKLGSQLDILAPVKY
What are the official names of this protein?
60S ribosomal protein L13a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RUVB_ECO7I
Sequence: MIEADRLISAGTTLPEDVADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATVRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ANMK_SHEFN
Sequence: MSKPEYFIGLMSGTSMDGVDAVLVDFSAEHPVLIASHTEAIPAHLLKGLQRLCQPETDEINRLGRLDRSVGKLFAQAVNHLLAKTTVTAAEVIAIGSHGQTVRHMPNLEMGFTLQIGDPNTIAIETNIDVIADFRRKDIALGGQGAPLVPAFHQQVFAQPGHSRVILNIGGIANITYLPGNSEQVLGFDTGPGNNLIDAFIQQNLNQPFDEDGAWADSGTTHPDLLKQLLSHSYFSLAYPKSTGRELFNRAWLEQQLADYSHLDQQDIQSTLLDLTCHSIANDINKLSPNGELFVCGGGALNKALMQRLATLVPGYKVDTTSALGVDAKWVEGIAFAWLAMRYHHDLPANLPAVTGASRTAILGGRFKAR
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RS16_ACTSZ
Sequence: MVTIRLSRGGAKKRPFYQIVVADSRSPRDGRFIERVGFFNPLATGKAERLRLDLDRVNAWVEKGASLSDRVSALVKEVQKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SSB_THEMA
Sequence: MSFFNKIILIGRLVRDPEERYTLSGTPVTTFTIAVDRVPRKNAPDDAQTTDFFRIVTFGRLAEFARTYLTKGRLVLVEGEMRMRRWETPTGEKRVSPEVVANVVRFMDRKPAETVSETEEELEIPEEDFSSDTFSEDEPPF
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: RLME_BURA4
Sequence: MAKNRFNQHWLHDHINDPYVKMAQREGYRARAAYKLKEIDEQDKLIRPGQVIVDLGATPGSWSQYARNKLAQGKKRDTQREGGIDGTIIALDLLPMEPIADVHFIQGDFREDDVLRQLEDVLEGRAVDLVISDMAPNLSGVASADAARIEHLCDLALEFAQNHLKPDGALLVKCFHGSGYSQIVEKFKQQFKVVAPRKPKASRDKSSETFILGRQLKQPR
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_MYCLE
Sequence: MTWHPQANRLKTFVLLVGMSTLIVVVGAIFGRTALFFATLVAVGINVYTYYNSDKLALRAMHAQPVSEVQAPVMYRIVRELATGAHQPMPRLYISDTNAPNAFATGRNPRNAAVCCTTGILEILNERELRAVLGHELSHVYNRDILISCVAGALAGVITALANMAMWAGTFGTTRDEENPFALLLVSLLGPIAATVVRLAVSRSREYQADESGAMLTGDPLALASALRKISSGVQAAPLPPEPQLASQAHLMIANPFRVGDRIGSLFSTHPPIEDRIRRLETMVAGR
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MYF5_HUMAN
Sequence: MDVMDGCQFSPSEYFYDGSCIPSPEGEFGDEFVPRVAAFGAHKAELQGSDEDEHVRAPTGHHQAGHCLMWACKACKRKSTTMDRRKAATMRERRRLKKVNQAFETLKRCTTTNPNQRLPKVEILRNAIRYIESLQELLREQVENYYSLPGQSCSEPTSPTSNCSDGMPECNSPVWSRKSSTFDSIYCPDVSNVYATDKNSLSSLDCLSNIVDRITSSEQPGLPLQDLASLSPVASTDSQPATPGASSSRLIYHVL
What is the function of this protein?
Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation (PubMed:29887215).  Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis.  Induces fibroblasts to differentiate into myoblasts.  Probable sequence specific DNA-binding protein.
What are the official names of this protein?
Myogenic factor 5, Myf-5, Class C basic helix-loop-helix protein 2, bHLHc2.
What are the subcellular locations of this protein?
Nucleus.
Protein: PPIF_BOVIN
Sequence: MMLALRCGPRLLGLLSGPRSAHLRLPAVRACSSGSGSHGSSSSSGNPLVYLDVGADGQPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSIYGSRFPDENFKLKHEGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGKTSKKIVITDCGQLS
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.  Involved in regulation of the mitochondrial permeability transition pore (mPTP).  It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated.  In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (By similarity).  Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity).  Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase F, mitochondrial, PPIase F, Cyclophilin D, CyP-D, CypD, Cyclophilin F, Rotamase F.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: FRLR_ECO57
Sequence: MSATDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFTDFGVSQGKATKEKVIEQERISAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGSSTYQLFQERFDTRVVSDKKTIDIFAATRPQAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRITLTIDNKRH
What is the function of this protein?
May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine.
What are the official names of this protein?
Probable fructoselysine utilization operon transcriptional repressor, HTH-type transcriptional regulator FrlR.
Protein: CRBA4_BOVIN
Sequence: MSGMFSGSISETSGMSLQCTKSAGHWKIVVWDEEGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYVLERGEYPSWDAWSGNTSYPAERLTSFRPVACANHRDSRLTIFEQENFLGRKGELSDDYPSLQAMGWDGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHHSGDYKHFREWGSHAQTFQVQSIRRIQQ
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Beta-crystallin A4, Beta-A4 crystallin.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: GATC_CYTH3
Sequence: MSLDTKTIGKIAHLARLEFDDKSLEAFSTDFNKILSWIDKLNEVNTDNVEPLIHMSHELNVLREDIDKVTISHEEALKNAPKKDSDYFRVPKFLS
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: GET1_BOVIN
Sequence: MSAAEADRWAWLLVLSFVFGCNVLRILLPSFSFFMSRVLQKDAEQESQMRAEIQGMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYILQAALMVSLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  Required to ensure correct topology and ER insertion of CAMLG.
What are the official names of this protein?
Guided entry of tail-anchored proteins factor 1, Tail-anchored protein insertion receptor WRB, Tryptophan-rich basic protein.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NTPPB_CHRVO
Sequence: MHIVLASTSRYRQEIIARLGLPFCAEPPVCDETPLPGETALETAVRLARVKAQSLAGKHPEALIIGSDQVALLDDKQIGKPGGFEQGVEMLKWMSGRTVVFHSALALYNTASGRLQECVGITRVTLRRLTEAQIRNYLTREPDALHCAGSAKSEGLGGALLEKVESDDPNALIGVPLFQLITMLGNEGVEVLK
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STX18_DANRE
Sequence: MAADITLLFKASVKTVKTRNKALGLMETTGREEPGAQKRPRPRQRDSFSCKAREVISNISKLKDFLLQHRKDYVNAGSVMSSEVSRMTDSERDQIDQDAQIFMRTCAEAISQLRSEMDKKQVSMQVKDHRAAVLDLIDSYLKGVCKLYSEQRAVRVKRVVDKKRLSRLEPEQINTEKRQSDGEENDKPVSDGNVDLWEENRVEDDLSPEEIQMFEQENQRLVGEMNSLLDEVRQIEGKVVEISRLQEIFSEKVLQQETEIDSIHQLVVGATENVKEGNEDIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS
What is the function of this protein?
Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
What are the official names of this protein?
Syntaxin-18.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Protein: PYRH_PHOPR
Sequence: MTTNPKPIYQRILLKLSGEALQGSEGFGIDAKVLDRMAQEVKELVELGVQVGLVIGGGNLFRGAGLAEAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARVMSAIPLNGVCDSYNWAEAISQLRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADIVLKATKVDGVYTDDPVKNPDAVLCDKLGFQDVLEKELKVMDLAAFTLARDHKMPIRVFNMTKPGSLRRVVMGEQEGTLIS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBB1A_HUMAN
Sequence: MESRDPAQPMSPGEATQSGARPADRYGLLKHSREFLDFFWDIAKPEQETRLAATEKLLEYLRGRPKGSEMKYALKRLITGLGVGRETARPCYSLALAQLLQSFEDLPLCSILQQIQEKYDLHQVKKAMLRPALFANLFGVLALFQSGRLVKDQEALMKSVKLLQALAQYQNHLQEQPRKALVDILSEVSKATLQEILPEVLKADLNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFSDENVPRLVNVLKMAASSVKKDRKLPAIALDLLRLALKEDKFPRFWKEVVEQGLLKMQFWPASYLCFRLLGAALPLLTKEQLHLVMQGDVIRHYGEHVCTAKLPKQFKFAPEMDDYVGTFLEGCQDDPERQLAVLVAFSSVTNQGLPVTPTFWRVVRFLSPPALQGYVAWLRAMFLQPDLDSLVDFSTNNQKKAQDSSLHMPERAVFRLRKWIIFRLVSIVDSLHLEMEEALTEQVARFCLFHSFFVTKKPTSQIPETKHPFSFPLENQAREAVSSAFFSLLQTLSTQFKQAPGQTQGGQPWTYHLVQFADLLLNHSHNVTTVTPFTAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLLLVGIHLLKSPAESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLAQPSHLMRQVARSVFGHICSHLTPRALQLILDVLNPETSEDENDRVVVTDDSDERRLKGAEDKSEEGEDNRSSESEEESEGEESEEEERDGDVDQGFREQLMTVLQAGKALGGEDSENEEELGDEAMMALDQSLASLFAEQKLRIQARRDEKNKLQKEKALRRDFQIRVLDLVEVLVTKQPENALVLELLEPLLSIIRRSLRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGALHAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMPTGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHITGPVRPRHQACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQQALSSLELLNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMKTLGVQRPKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAATGGSQPPSMGRKKRNRTKAKVPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQVNGAPGSPTEPAGQKQHQKALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKAQVRKAGKP
What is the function of this protein?
May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity).  Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity).  Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity).  Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity).  Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309).
What are the official names of this protein?
Myb-binding protein 1A.
What is the protein family that this protein belongs to?
Belongs to the MYBBP1A family.
Protein: HEM1_BURM1
Sequence: MQLLTIGINHHTAPVALRERVAFPLEQIKPALVTFKNVFLGPQAPNAPEAAILSTCNRTELYCATDDRAARDAAIRWLSDYHRIPVDELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQILGQMKDAVRTASEAGALGTYLNQLFQRTFAVAKEVRGTTEIGAQSVSMAAAAVRLAQRIFEKVSDQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGQRLAERFNGRAMPLSDLPARMQEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVSKLKDVFLYTVDDLGAIVREGNASRQAAVAQAEAIIETRVQNFMQWLDTRSVVPVIRHMHTQADALRRLEVEKAQKMLARGDDPAAVLEALSQALTNKLIHGPTSALNRVNGADRDSLIELMRGFYQHAPRSNDQSGH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: EPMA_SALAR
Sequence: MSETATWQPSASVPNLLKRAAIMTEIRRFFADRGVLEVETPCMSQATVTDIHLFPFETRFVGPGHSQGMNLYLMTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQVLDCQPAESLSYQQAFQRHLEIDPLSADKTQLREAAAKLDVSNIADTEEDRDTLLQLLFTVGVEPHIGKEKPTFIYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQQPIDNHLLDALKAGMPDCSGVALGVDRLVMLALGAERLADVIAFTVDRA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'.  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34'.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: LIPA_CERS1
Sequence: MIGKLVRDLKIPDQRHPEKAHRPDNVQPKKPSWIRVKAPTSEGYKETRDIIRGQKLATVCEEAGCPNVGECWSQGHATMMIMGEICTRGCSFCNVATGRPQALDAFEPGRVAHAVSQLGLKHVVVTSVDRDDLEDGGAEHFAQTIRAIRHRAPATTIEVLVPDFLKCGPSALETVVAARPDVFNHNLETVPGLYPEVRPGARYFHSLRLLQRAKELDPSIFTKSGIMVGLGEDRQGVLQVMDDMRSAEVDFLTIGQYLQPTPKHHRVDRFVTPEEFAGYEKAAYGKGFLMVSATPLTRSSYHAGDDFARLRDARQKRLGA
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBI_ECOL5
Sequence: MGIKGMWKDLRTSPVDTLVRWQEQRLLWLLMAVAMGALIILAHSFFQIYLYMAPCEQCVYIRYAMFVMVIGGLVAAINPKNIILKLIGCVMAFYGSILGLKFSLKLNDIHHAVHNPDPDSLFGVQGCSTDPTFPFNLPLAQWAPNWFKPTGDCGYDAPIVPDGVTLSSTQQWFVEMYQQSEGWYLLPPWHFMNMAQACMLAFGMCLVLLVIMSGAWALKIIRG
What is the function of this protein?
Required for disulfide bond formation in some proteins.  Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT.
What are the official names of this protein?
Protein-disulfide oxidoreductase DsbI.
What is the protein family that this protein belongs to?
Belongs to the DsbB family. DsbI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.