PharMolix/UniProtQA huggingface dataset:
Protein: DNLI_METMP
Sequence: MLFSDFCKILDKIEKTTKRLEKTDYFVELIDFIKTSEKPENLKQVSQITIGRVFAEFENKEIGIGPNLLLEAVKTTGIPEKDLKSKIKETGDIGTAVENLSSNIKQVSLFSQALTLEEVYSTLKKLSEIEGNSSQKKKTRIISNLLILADPVESRYISRLILEDMRIGMNIPTILASFSNYFNVNKESVEKIYAVTNDIGLLGEKLISGSDIENDPELKLKVFRPIKPMLAQLTPSIEDAMIETKMPQFETKYDGARVQVHKSNGDVKIYSRRLENITNSVPELVEEIKKLDIDNIILEGECVAMDLDSGKPRPFQDILRRFRRKYNIDKMAEKIALRIYFFDVLYYNRGLIDTPLKTRREILEKLFGTNNWDSELEKIKKEIFSSKMLFSSFKLNSGDPNLVKEFFNWSLSIGHEGIMIKNPDAPYTPGSRVKTMYKVKPTLENLDVVVTRAKIGMGKRKDWYGSYELSVKDNDGNLHVIGNVGSGLTEDDLEKLTKIVNEIKIEDLGEEVILEPKIVLEVTYEEIQTSEKYEMGYALRFPRVVQIREDKSINDINTLDDVKKIYEIERNRK
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: CEP20_MOUSE
Sequence: MATVTELKAVLKDTLEKRGVLGHLKARIRAEVFNALDDDREPRPSLSHENLLINELIREYLEFNKYKYTASVLIAESGQPVVPLDRQFLIRELNAFEESKDNSIPLLYGILAHFLRGPPDGAQNVLLTESTLHPATKHLSWKPSRRPDDDHVRKDTGPRTTTEELPAAAQAVSR
What is the function of this protein?
Involved in the biogenesis of cilia (By similarity).  Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity).
What are the official names of this protein?
Centrosomal protein 20, FGFR1OP N-terminal-like protein, FOP-related protein of 20 kDa, LisH domain-containing protein FOPNL.
What is the protein family that this protein belongs to?
Belongs to the CEP43 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP.
Protein: RDRP_P1AMV
Sequence: MSNVRNVFSQLTDPSLKAVIQDEAYRVLKRELAQTRHTNPFAQSPEAADALEALGINSHPYAITSHTHAAAKAIESDLYEVVSHYLPKENPVSFLFMKPAKLRFFHRGPTHGDHFLNAHVEPKDVPRYPQETIINRLADIPTQIAFMGDTLHFLSPSFLTALFAHSPRLQTLYATLVLPPEPSTSRSLYPQIYTLTYSEDGFMYIPGGHAGASYFHKYDQLEWLTVGHLTAPGCPTVTAQRLETKGANHLFIFQRGNYITPERRTFATNDQYVTVPHIFLPENYNCRTPISKTTMMQMFFYIKSGKEAQREGHLGQVQQLISTKELQHYQPSEITLLVNYFEFTATLDSHTCFEDVPPKLAPKTTPAPPLGISRILQFFRGRPSFVKLIKALDWQPITLEFPVRDVRTTVRGPPGFKNPFTQPQPVNPEDADISSRFQDFSRATNSTPKPTVEAVLEASAESPDHHTQLKVLCSALSEGQLEAIHALGHSRCGGPLLPELTAKSTPVEQCPDLPPCPTKSQASPASSNPSGPDAQPTAQNPETLPWVAWLPKLNALGFEALEVQHDPSTGEMIMPITDTQELPRATLPAHWQGHNLERILSTLRSLNRFPTPWSPDRTRARAFTSDVKNSRTGKALHRESQTWKETQTMLTENTQTELAISVIHGAGGSGKSQALQTLLRQDHSLPIEVVLPTNELRLDWLKKLPHNPPEQFRTFERAFVSSHSPVVIFDDYGKLPQGYLEAFALTHANLELVILTGDPRQSTHHESNEEALISKLPPATTIYSAFSRYYINATLRNSKFLANKLGVYSANSCPLNVTYGFQPLPGLHLLVPSLMKKAAFTDAGHKVSSYAGCQGITAPKVQILLDNDTTMCTKEVLYTALSRAVDSIHFVNTNAQSSAFWEKLEATPYLKTFLSLVREDKITEFQAPADAPKPVTPPVTHFPVEEPATTLDDFKEELRDKFDREIFTSDRGHTNCVQTDDPTTQLFSHQQAKDEALLWEMIRARLKISTPEANIEEFRAKKDLGDILWVNYHRAMGLPKEQPDFSEDLWNRCAEEVQNTYLKKTMAQLKGGERRQSPDFHEHQILIFLKSQWVKKMEKLGAKEIKPGQTIASFQQHAVMLYGTMARYMRRFRDALSPNNIMINCEKTPQDLSRWVLNYWDFSKPSYANDFTAFDQSQDGAMLQFEILKAKYFNLPEWVIEGYLDIKLSPKIFLGTLSIMRLTGEGPTFDANTECNIAYTHTRFDIPEGTAQIYAGDDCAIAQVCPEKPSFALLKNRIALQAKPAYTPQERGQWAEFCGYLITPKGLIKDPLKLHASLELAKAQKKAGVRDAITNVVANYSLDAKLAYSLGDDLQDLLSPHQAHLHQVTVRDLVKFGGSPFLNSD
What is the function of this protein?
RNA replication.  The central part of this protein possibly functions as an ATP-binding helicase (Probable).
What are the official names of this protein?
RNA replication protein, 156 kDa protein, ORF1 protein.
What is the protein family that this protein belongs to?
Belongs to the potexvirus/carlavirus RNA replication protein family.
Protein: INS_CAIMO
Sequence: AANQHLCGSHLVEALYLVCGERGFFYSPKTGIVEQCCENPCSLYQLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYG_BDEBA
Sequence: MKIKHLEDLNTLVSLSKRRGFVFQSSEIYGGLGSCWDYGPLGSLMKLNVKRAWWNAMTRRPDIVGLDAAILMHPMVWKASGHVDGFSDPLVDCKECKTRFRADNTDSYINEKKCPNCGSKNLSEERSFNLMFKTHMGPLEDSGSVVYLRPETAQGHFVNFQNCQQASRYKIPFGIAAIGKSFRNEITPGNFIFRTREFEQMEMQYFVEPGTDEQFFKEWKERRWNFYIKFGIKPENLKFKDHDKLAHYAKAAVDVEFKFPMGFSELEGIHNRSDFDLSQHMKFSGKNLEYFDEPNKKKYIPYVIETAVGCDRLFLAFLCDAYREEVTTDEAGKEDVRVVMGLHPEIAPFKVAVLPLSKKEELSSISEKLRDQLAEDFDVNYDESQSIGKRYRRQDEIGTPFCVTVDFDTINDQAVTVRHRDKMTQERVAITQLNAYIAAKLKTFNQ
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIR2_HHV8P
Sequence: MASKDVEEGVEGPICWICREEVGNEGIHPCACTGELDVVHPQCLSTWLTVSRNTACQMCRVIYRTRTQWRSRLNLWPEMERQEIFELFLLMSVVVAGLVGVALCTWTLLVILTAPAGTFSPGAVLGFLCFFGFYQIFIVFAFGGICRVSGTVRALYAANNTRVTVLPYRRPRRPTANEDNIELTVLVGPAGGTDEEPTDESSEGDVASGDKERDGSSGDEPDGGPNDRAGLRGTARTDLCAPTKKPVRKNHPKNNG
What is the function of this protein?
Membrane-bound E3 ubiquitin ligase expressed at the immediate early stage of viral reactivation to mediate polyubiquitination of various host membrane proteins related to the immune response (PubMed:10799607, PubMed:10859362, PubMed:11413168, PubMed:24899205).  Promotes ubiquitination and subsequent degradation of host MHC-I, CD86, DC-SIGN and DC-SIGNR, ICAM1 and CD1D molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell (PubMed:11413168, PubMed:23460925).  Binds target molecules through transmembrane interaction.  E3 ubiquitin-protein ligases accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfer it to target protein.  The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed.  Alters monocyte metabolism and proliferation by mediating rapid internalization of cellular growth factor-binding receptor tyrosine kinases from the surface leading to increased signaling (PubMed:21490960).
What are the official names of this protein?
E3 ubiquitin-protein ligase MIR2, IE1A protein, Modulator of immune recognition 2, ORF K5, RING-type E3 ubiquitin transferase MIR2.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein. Host endoplasmic reticulum. Note=Probably exerts its effects at the plasma membrane during viral infection.
Protein: SYH_RUEPO
Sequence: MAKPKKTPRPKAETPKGFRDYFGAEVTQRTEMLRDIAGVYHRYGFEALESSAVETVEALGKFLPDVDRPNEGVFAWQESEDDGAGDWMALRYDLTAPLARVYAQHRNDLPTPYRRYAMGPVWRNEKPGPGRYRQFYQCDADTVGSASMAADAEICAMLSDTLETVGIPRGDYVVRVNNRKVLNGVLETMGLADEGQRDAVLRTIDKFDKVGEDGVRELLGKGRLDASGAFIDGVGLSDDQAGPVLAFLTSRGADAATTVANLRAAVGASQIGVQGIDELEQIGDLLAAGGYGPDRIVIDPSVVRGLGYYTGPVYEAELTFEIFDEKGRKRQFGSVSGGGRYDDLVKRFTGQEVPATGVSIGVDRLLAALREKGRIRTAERGPVVVTVMDRDRMADYQAMVAELRNAGIRAEVYLGNPKNFGNQLKYADKRNSPVAVIEGGDERANGVVQIKDLILGAQIAANATLEEWKERPSQYEVARADLVAKVREILAEQAG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POLG_DEN23
Sequence: MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFEVIKTEAKQPATLRKSCFEAKLTNTTTESRCPTLGEPSLNEEQDKRLVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKFVHPENLEYTIVITPHSGEEHAVGNDTGKHGKELKITPQSSITEAELTGYGTVTMQCSPRTGLDFNEIVLLQMEDKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMQTALTGAAEIQMSSGNLLFTGHLKCRLRMDKLQLKGISYSMCTGKFKIVKEFAETQHGTIVIRVQYEGDGSPCKIPFEIIDLEKRHVLGCLITVYPIVTEKDSPVNIEADPPFGDSYIIIGIEPGQLKLHWLKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALNQVFGTIYGAAFSGVSWTMKILIGVIITCIGMNSRSTSLSVSLVLVGVVTLYLGGMVHA
What is the function of this protein?
Binds to host cell surface receptor and mediates fusion between viral and cellular membranes.  Envelope protein is synthesized in the endoplasmic reticulum in the form of heterodimer with protein prM.  They play a role in virion budding in the ER, and the newly formed immature particle is covered with 60 spikes composed of heterodimer between precursor prM and envelope protein E.  The virion is transported to the Golgi apparatus where the low pH causes dissociation of PrM-E heterodimers and formation of E homodimers.  prM-E cleavage is inefficient, and many virions are only partially matured.  These uncleaved prM would play a role in immune evasion.
What are the official names of this protein?
Genome polyprotein.
What are the subcellular locations of this protein?
[Envelope protein E]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ATPB_PSINU
Sequence: MKINLLTFGVSTLVERNIGYITQIIGPVLDAAFPPGKMPNIYNSLIVKGQNPAGQQINVTCEVQQLLGNNKVRAIAMSATDGLTRGMEVIDTGAPLSVPVGQATLGRIFNVLGEPVDNLGPINADKKSSIHEPAPAFTQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYTEMKESKVINEQNLSESKVALVYGQMNEPPGARMRVGLTALTIAEYFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPWIVGEEHYETAQGVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVSLAETIKGFQMILSGELDSLPEQAFYLVGNIEEATAKAGISQMED
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ISAA_STAAC
Sequence: MKKTIMASSLAVALGVTGYAAGTGHQAHAAEVNVDQAHLVDLAHNHQDQLNAAPIKDGAYDIHFVKDGFQYNFTSNGTTWSWSYEAANGQTAGFSNVAGADYTTSYNQGSNVQSVSYNAQSSNSNVEAVSAPTYHNYSTSTTSSSVRLSNGNTAGATGSSAAQIMAQRTGVSASTWAAIIARESNGQVNAYNPSGASGLFQTMPGWGPTNTVDQQINAAVKAYKAQGLGAWGF
What is the function of this protein?
Is able to cleave peptidoglycan.
What are the official names of this protein?
Probable transglycosylase IsaA, Immunodominant staphylococcal antigen A.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase family. IsaA subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DPS_MYCS2
Sequence: MTSFTIPGLSDKKASDVADLLQKQLSTYNDLHLTLKHVHWNVVGPNFIGVHEMIDPQVELVRGYADEVAERIATLGKSPKGTPGAIIKDRTWDDYSVERDTVQAHLAALDLVYNGVIEDTRKSIEKLEDLDLVSQDLLIAHAGELEKFQWFVRAHLESAGGQLTHEGQSTEKGAADKARRKSA
What is the function of this protein?
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity).  It protects DNA from hydroxyl radical-mediated cleavage.  Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation.  Is unable to protect DNA from DNase-mediated cleavage (By similarity).
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YQGF_BACAN
Sequence: MRILGLDVGTKTVGVAISDEMGWTAQGLETIKINEERGQFGFDRISELVKQYDVDKIVVGLPKNMNGTIGPRGEACQQFAENLRELLQLDVVMWDERLSTMAAERLLISADVSRKKRKQVIDKMAAVVILQGFLDSK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEGS_VIBPA
Sequence: MKTIRAILNGKKAGNPELRDAIMKMRDRGVDVQVRVTWESQDMPRLVKEAVTDGIERIVVAGGDGTVNEAASALIHIDHESRPELAIIPLGTANDFATANHIPDSIADALTLAVEGQALSVDCVKANDRCFINVAAAGFGAEVTAETPVELKNFLGGGAYTLTGVVKALGFKPYDGSITIEGGRYDGEMLLGAFCNSRLAGGGQQLAPNAMIDDGLMDLTLVRPFLPHELPKVIEEINNPSEKGEFVKHTRASWLEIDFPNPLPLNLDGEPYHSRKIRFEVQPKSLKLVLPKDCPCVTH
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS-like.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_ACIBC
Sequence: MKDLLDIMRKKTDSDGHAPVEFDRIRIGLASPEMIKSWSHGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECLCGKYKRMKYKGVICEKCGVEVTTAKVRRERMGHIELASPVAHIWFLKSLPSRIGLLLDMTLRDIERVLYFESYVVTDPGMTPFEKYQLLNDEEYFTALEEHGDEFVAKMGAEAVQDLLKDIDLEAEISRLREEIPQTTSETKLKKASKRLKLMEAFKDSNNKPEWMVMNVLPVLPPDLRPLVPLEGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPTLRLHQCGLPKKMALELFKPFIFAKLQASGQATTIKAAKKMVERETPEVWDVLASVIRQHPVMLNRAPTLHRLGLQAFEPILIEGKAIRLHPLVCAAFNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYITRDAVNAKGEGMVFADTHEVNRALATGQVAIHARVKVRVHQTVINENGEREQQTIIVDTTPGRCLLWEVVPEGLSFDMINLEMTKKNISKLINSCYRKLGLKDTVIFADQLMYLGFRQATRSGVSVGMEDMLIPPTKHTIIDKAETEVREIEQQFEQGFVTAGERYNKVVDIWARTNDQVAKAMMDNLSYTLVKNKQGEDEKQKSFNSIYMMSDSGARGSAAQIRQLAGMRGLMAKPDGSIIETPIKANFREGLTVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVITEPDCGTSGGLVMTPFIQGGDVIEPLRDRVLGRVTAEDVRRASDDEVVLPRGTLIDEKIAAQLEEAGVDEVKVRSVIACESTFGVCAKCYGRDLARGHLVNPGESVGVMAAQSIGEPGTQLTMRTFHVGGAASRTSAANSVQVRNKGTVRFHNVKTVQHAKGHLVSVSRSGEIGIADELGRERERYKLPYGASILLKDGELVEAGGIVATWDPHTHPLVTEVAGKARFSQIADGVTATSKTDDATGMTTVEILPVTARPASGKDLRPAIVLDTTDGGEQFYFLPQNTIVTVRDGETIGVGDVIGRVPQESSRTRDITGGLPRVADLFEARKPKEHAILAEVSGIVSFGKETKGKNRLVITPDDGSEIYEELIPKWRQINVFEGEHVNRGETISDGPQNPHDILRLKGEVALTNYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKVDIIDGGDTSFIKGEQVDYIRVVQENQAVLAQNKFPAKFERQLMGITKASLSTDSFISAASFQETTRVLTEAAVTGKEDDLRGLKENVVVGRLIPAGTGLAYHLERRRQEAEAAEHALHNDFSEVDQAFSQALNSEQF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: DNLJ_CLOBH
Sequence: MDNKLEKMKELVEELNQYAYEYYVLDNPSISDKEYDLKYDELVILEKKTEVTLPYSPTQRVGDKILGEFSKYTHKGRLWSLDKAQNMEQLIEWHNRNLKVIEQYNSMSEDKLPELRYIVTKKFDGLTVNCTYDENGILIKSATRGTGIIGEDITAQIKTIKTVPLKIKNNHVIEVHGEAIMTKTAFEEYNKAAQVPLKNLRNGAAGALRNLDIKETARRNLSAFFYDVGYNEGPEFKSYREMMNFIKNMGLPQDKYIKECTNMEEVEKEIEYIESIRGELDYDIDGAVIVVDDIKTREILGYTIKFPKWAIAYKFEAKEITTKLLDVEWNVGRSGRVTPTALLEPVELGGVTVKRATLNNMDDIKRKNVKLGAKVLVRRSNDVIPEIMGVVEESLEESKEIQAPDRCPYCNSHLVQNGVHYYCENTLSCKPQMVKSIVHFASREAMNIAGFSEKTAEQLFEKLDIKSIADLYKIKKEELLTLEKFKDKKSQNLIDAIQNSKNCDLASFIYALGIPNVGKKTANDLVMKFKTLESIKNTTIEQLVEVPDVGEIVAKSIYDFFEDEKVISNIEELLNLGVKPYYEEERIDENPFMDKTIVVTGSLNNYSRGEIKDKLQSLGAKVSSSVSKNTDYVLVGEKPGSKYEKAIELGVKVINEEEFSNKIK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: HSP1_PHACL
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRHHNRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TAER_MYCTO
Sequence: MSPAEREFDIVLYGATGFSGKLTAEHLAHSGSTARIALAGRSSERLRGVRMMLGPNAADWPLILADASQPLTLEAMAARAQVVLTTVGPYTRYGLPLVAACAKAGTDYADLTGELMFCRNSIDLYHKQAADTGARIILACGFDSIPSDLNVYQLYRRSVEDGTGELCDTDLVLRSFSQRWVSGGSVATYSEAMRTASSDPEARRLVTDPYTLTTDRGAEPELGAQPDFLRRPGRDLAPELAGFWTGGFVQAPFNTRIVRRSNALQEWAYGRRFRYSETMSLGKSMAAPILAAAVTGTVAGTIGLGNKYFDRLPRRLVERVTPKPGTGPSRKTQERGHYTFETYTTTTTGARYRATFAHNVDAYKSTAVLLAQSGLALALDRDRLAELRGVLTPAAAMGDALLARLPGAGVVMGTTRLS
What is the function of this protein?
Involved in the reduction of the double bond between C-4 and C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
What are the official names of this protein?
Trans-acting enoyl reductase.
What is the protein family that this protein belongs to?
Belongs to the saccharopine dehydrogenase family. Enoyl reductase subfamily.
Protein: YCIC_SALA4
Sequence: MSITAKSVYRDAGNFFRNQFITILLVSLLCAFITVVLGHAFSPSDAQIAQLSEGEHLAGSAGLFELVQNMTPEQQQILLRASAASTFSGLIGNAILAGGIILMIQLVSAGHRVSALRAIGASAPALPKLFILIFLTTLLVQIGIMLIVVPGIIMAIVLALAPVMLVEEKMGVFAAMRSSMRLAWANMRLVAPAVIGWLLAKTLLLLFAPSFAVLTPNVGAVLANTLSNLISAVLLIYLFRLYMLIRQ
What are the official names of this protein?
UPF0259 membrane protein YciC.
What is the protein family that this protein belongs to?
Belongs to the UPF0259 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: APT_CORK4
Sequence: MTDSEYSSAADAVANLVRRVPGFPSEGVVFEDLTPVLADAGAFRLIVDELAEAARSYHADIIGGLDARGFLLGSAVAYQLGLGILAVRKEGKLPPPVFHRGYDLEYGHAALEIPREGLNIQGKNIVLIDDVLATGGTLCASRALLEEAGANVAGLAVILEVEALEGRKRLADLPLTVVGERSE
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_VIBA3
Sequence: MRTSNYLLSTLKETPNDAEVISHQLMLRAGMIRKLASGLYTWLPTGLRVLRKVENIVRQEIDNAGAVEILMPVVQPFELWEETGRSEKMGPELLRFTDRHSRPFVLSPTAEEVVTSLVRNEISSYKQLPLNLYQIQTKFRDERRPRFGVMRAREFSMMDAYSFDIDKEGLEKSYQAMHDAYCKAFDRMGLEYRPVLADSGAIGGSGSQEFHVLAESGEDLIAFSSESDYAANIEKAEALAPTEEVAAPTQEMELVDTPNAKTIAELVEQHGLAIEKTVKTLFVKASDEVEADIIALIVRGDHELNEVKAENLPQIASPLEMASEEEIRALVGAGPGSLGPVGLELPFIADRSVAVMSDFGAGANVDGKHYFGINWGRDVELAQVEDLRNVVEGDLSPCGQGTIQLKRGIEVGHIFQLGNTYSKAMNCNVLGPDGKSVILEMGCYGIGVSRVVASAIEQNHDKFGITWPDALAPFQVAIVPMNMHKSERVKEAAEKLYAELTAMGIEVLFDDRKERPGVMFKDIELVGIPHTIVIGDRSMDEGNFEYKNRRTGDKEAIAMDTVIEHLKAQLA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SBNH_STAA8
Sequence: MRIVQPVIEQLKAQSHPVCHYIYDLVGLEHHLQHITSSLPSNCQMYYAMKANSERKILDTISQYVEGFEVASQGEIAKGLAFKPANHIIFGGPGKTDEELRYAVSEGVQRIHVESMHELQRLNAILEDEDKTQHILLRVNLAGPFPNATLHMAGRPTQFGISEDEVDDVIEAALAMPKIHLDGFHFHSISNNLDSNLHVDVVKLYFKKAKAWSEKHRFPLKHINLGGGIGVNYADLTNQFEWDNFVERFKTLIVEQEMEDVTLNFECGRFIVAHIGYYVTEVLDIKKVHGAWYAILRGGTQQFRLPVSWQHNHPFDIYRYKDNPYSFEKVSISRQDTTLVGQLCTPKDVFAREVQIDAISTGDVIVFKYAGAYGWSISHHDFLSHPHPEFIYLTQTKEDE
What is the function of this protein?
Catalyzes the decarboxylation of citryl-L-2,3-diaminopropionic acid to citryl-diaminoethane, the second step in staphyloferrin B biosynthesis.
What are the official names of this protein?
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase, Staphyloferrin B biosynthesis protein SbnH.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Protein: SULF1_HUMAN
Sequence: MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLADSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENNRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQCNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
What is the function of this protein?
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563).  It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:12686563).  Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed:12686563).
What are the official names of this protein?
Extracellular sulfatase Sulf-1, hSulf-1, Arylsulfatase, N-acetylglucosamine-6-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface.
Protein: SYR_METNO
Sequence: MNIFAAFEERIGEALASLTRAGQLPEGLDLGRVVVEPPRDPSHGDLATNAALVLAKEARTNPKALAERLAAELRSDPRVTEASVAGPGFLNLRLAPQVYGDVVRAALRAGEAFGRGAKQPGLVNVEYVSANPTGPMHVGHGRGAVFGDALANLLVAAGREVVREYYINDAGAQVDVLARSAFLRYREALGEEIGTIPEGLYPGDYLKPVGAMLAKTHGRSLLGKPEAEWLPLVREAAIGAMMERIREDLAALGIRHDVFFSERTLQEGGKEGGEGGAVARLIEALRARDLVYVGRLPPPKGQLPEDWEDRDQTLFRSTAFGDDIDRPLLKSDGSYTYFASDIAYHASKVERGATELIDVLGADHGGYVKRMQAAVRAVSDGRASLDVKLCQLVRLLRGGEPVKMSKRAGEFVTLREVIDEVGRDPVRFMMLYRKNDATLDFDLAKVVEQSKDNPVFYVQYAHARTASVFRQAREAFPGEDLSAEALAGADLSLLTDSGEAEIMRLIAQYPRVVESAGSAHEPHRLAFYLYELASAFHSFWNKGKDLPQLRFVNQTDRMSTLSRLALVAALRGVLASGLGILGVTAPDEMR
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.