PharMolix/UniProtQA huggingface dataset:
Protein: GMHA_EDWI9
Sequence: MYQDLIRSELNEAAQTLNNFLADEANILAIQQAAQLLAASFKADGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDPSHLSCVSNDFGYDYVFSRYVEAVGREGDVLLGISTSGNSGNIIRAIEAARAKGMKVITLTGKDGGKMAGSADVEIRVPHFGYADRIQEIHIKAIHIMIQLIEKEMASV
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_CERS5
Sequence: MGIQAAEISAILKEQIKNFGQAAEVAEVGRVLSVGDGIARVHGLDNVQAGEMVEFPGGIRGMALNLEVDNVGVVIFGDDRSIKEGDTVKRTKSIVDVPAGDALLGRVVDGLGNPIDGKGPIAATERRVADVKAPGIIPRKGVHEPMATGLKSVDAMIPIGRGQRELIIGDRQTGKTAIALDTILNQKSYNEAAGDDESKKLYCIYVAIGQKRSTVAQLVKKLEETGAIAYTLVVAATASDPAPMQFLAPYAATAMAEYFRDNGRHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERSAKLNKEHGSGSLTALPIIETQGGDVSAFIPTNVISITDGQIFLETELFYQGIRPAVNTGLSVSRVGSSAQTDAMKSVAGPVKLELAQYREMAAFAQFGSDLDAATQQLLNRGARLTELMKQPQYAPLTNAEIVCVIFAGTKGYLDKVPVKDVGRWEQGLLKHLRTNARDLLADITNNDRKVKGELENKIRAALDTYAKDFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CYF_SACOF
Sequence: MENRKTFSWLKEQMIRSISVSIMIYVITRTSISNAYPIFAQQGYENPREATGRIVCANCHLANKPVDIEVPQAVLPDTVFEAVLRIPYDMQLKQVLANGKKGGLNVGAVLILPEGFELAPPDRISPELKEKIGNLSFQSYRPNKKNILVIGPVPGKKYSEIVFPILSPDPATKKDVHFLKYPIYVGGNRGRGQIYPDGTKSNNTVYNATSTGIVKKILRKEKGGYEISIVDASDGRQVIDIIPPGPELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFFASVILAQVFLVLKKKQFEKVQLYEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CFMB_ARTBC
Sequence: MKFSQAVIALAAATVVSAQLPDVPQCSLPCFLDALTTDGCSELTDFKCHCSKPELPAKITPCVKSKCPVAEQVSVSNAVVKQCSEAGAPVSIPPVEESSSKPSEPSTSEAPTASPTESTPAPTTPAPTGTGSPSGTGAPGGPSGTGTFTNTGVPTQSTPIYTGAASGLSANIGGMGAAILAIAAYL
What is the function of this protein?
GPI-anchored cell wall protein involved in stabilizing the cell wall (By similarity).
What are the official names of this protein?
GPI-anchored hemophore ARB_02741, GPI-anchored CFEM domain protein ARB_02741.
What is the protein family that this protein belongs to?
Belongs to the RBT5 family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall. Cell membrane; Lipid-anchor, GPI-anchor. Note=Found anchored in the cell membrane as well as a covalently-linked GPI-modified cell wall protein (GPI-CWP).
Protein: Y733_MYCTA
Sequence: MPRAHDDNWDLASSVGATATMVAAGRALATKDPRGLINDPFAEPLVRAVGLDFFTKLIDGELDIATTGNLSPGRAQAMIDGIAVRTKYFDDYFRTATDGGVRQVVILAAGLDARAYRLPWPAGTVVYEIDQPQVIDFKTTTLAGIGAKPTAIRRTVYIDLRADWPAALQAAGLDSTAPTAWLAEGMLIYLPPDPRTGCSTTAPNSVLRAARSLPNLSRALWISTQAGYEKWRIRFASTAWTSTWRRWCIPANAATSSTTCAPRAGTLRAQCGPTYSGAMVCPFPPHTTTIRSAKSSSSAVV
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MRA_0733.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: GNPAT_BOVIN
Sequence: MDHSSSSNSCFSVGSTSPGAVVLLYSKELKKWDEFEDVLEERRHVSDLKFAMKCYTPLVYKGITPCKPSDIKCSVLNSEEIHYVIKQLSKESLQPVEVLREEACEILDEMSHKLRLGAIRFFAFALSKIFKQIFSKVRVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDRILEETLYAYELLGVPKPKESTTGLLKARRILSEKFGNIHVYFGDPVSLRSLAAGRMGRSPYNLVPRYIPQKQSEEMHTFVTEVAYKMQLLQIQNLVLSPWPLIVAVLLQNRPSIDFDALLEKTLWLKGLTQAFGGFLTWPDNEPAEAVIQSSILLHSNIVSLVKDRVILKMECGDSELVDGLIFQHITLLMCLAYRNQLLNVFVRPSLVAMALQMTPGFRKEDVYSCFRFLCSVFSDEFIFLPGNALKDFEEGCYLLCKSEAIQVMTRDILVTEKGNSVLEFLIGLFKPFVESYQIICKYLLNEEEDYFTEKQYFIRVRKFTSQLLDQGASQCYDVLSSDVQKNALAAFVRLGVVEKKKVNNDYIFNVNEPATTKLEEMLGCKTPVGKPATAKL
What is the function of this protein?
Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis.
What are the official names of this protein?
Dihydroxyacetone phosphate acyltransferase, DAP-AT, DHAP-AT, Acyl-CoA:dihydroxyacetonephosphateacyltransferase, Glycerone-phosphate O-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Peroxisome membrane; Peripheral membrane protein; Matrix side. Note=Exclusively localized to the lumenal side of the peroxisomal membrane.
Protein: CYB_PTEVA
Sequence: MTNIRKSHPLFKIINDSLIDLPAPSNISSWWNFGSLLGICLAIQILTGLFLAMHYTSDTTTAFQSVTHICRDVNYGWILRYLHANGASMFFICLFLHVGRGLYYGSYMYKETWNVGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTKLVEWIWGGFSVDKATLTRFFAFHFLLPFIISALVLVHLLFLHETGSNNPTGVPSDSDMIPFHPYYTIKDMLGALVMILALLMLVLFSPDLLGDPDNYIPANPLNTPAHSKPEWYFLFAYAILRSIPNKLGGVLALVLSILILILMPLLHTSKQRSMMFRPLSPCMFWLLVADLLTLAWIGGQPVEHPCIIIGHFASILYFLLILVLMPIMSIVDNHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: QUEF_CAUVN
Sequence: MTDLNVTQLGRVVDAPESPEAAVLERVPNPQSDVLYLARFVAPEFTSLCPVTGQPDFAHLVIDYAPGDWLIESKSLKLYLTSFRNHGSFHEDCTVKVARKIVEIAQPRWLRIGGYWYPRGGIPIDVFWQTGPAPEGLWVPDQGVAPYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1166_BACAN
Sequence: MAKDSSFDIVSKVELPEVTNAINTALKEIQNRYDFKGSKSDIKLEKEVLVLTSDDEFKLEQVKDVLISKLVKRNVPIKNLDYGKVEAAAGNTVRQRATLQQGIDKDNAKKINNIIKEMKLKVKTQVQDDQVRVTAKSRDDLQAVIAAVRSADLPIDVQFINYR
What are the official names of this protein?
UPF0234 protein BA_1166/GBAA_1166/BAS1081.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: LPIN1_HUMAN
Sequence: MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLPLLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPFENQDIHSASA
What is the function of this protein?
Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281, PubMed:29765047).  Is involved in adipocyte differentiation (By similarity).  Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity).  Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).
What are the official names of this protein?
Phosphatidate phosphatase LPIN1, Lipin-1.
What is the protein family that this protein belongs to?
Belongs to the lipin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum membrane. Nucleus membrane. Note=Translocates from the cytosol to the endoplasmic reticulum following acetylation by KAT5.
Protein: NUOC_COXBN
Sequence: MAEKQTLIDAINDRFNSQIEAVVAGVDMVTIELLPTHLLEVCTALRDDPPFNFELLLDVCGVDYLEYGMSPWRTEETPNTGFSRGFEEVIQEQIIPWNKPRFAVVYHLLSLRHNHRIRLKTYVEGDPPLVPSVIKIWSSADWYEREAFDLYGIVFEGHPDLRRLLTDYGFVGHPFRKDFPLIGEVELRYDAAQQRCVYEPVSIQPRVLVPKVIRVDSRYEKGEKENG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ILVD2_BORPA
Sequence: MSDNNRSRHITEGVARAPNRAMYYALGYTEADFQNPMIGVANGHSTITPCNSGLQRLADAAIEAIRVSRANPQVFGTPTISDGMSMGTEGMKYSLVLREVIADCIETAAQGQWMDGVVVIGGCDKNMPGGMMALARMNVPGIYVYGGTIKPGHYKGKDLTIVSVFEAVGEYTMGRMDETDFKAIEQCAIPGSGSCGGMYTANTMSSAFEAMGMSLPHSSTMANEDQEKVASAAESARVLVEAVRRQLRPRDIITRASIENAVAVIMATGGSTNAVLHFLAIAHAAEVPWNIDDFERIRKRVPVICDLKPSGKYVATDLHRAGGIPQVMKILLNAGLLHGDCITITGKTVAETLANVPDAPPPGQDVIMPIERAFYPQGHLAILKGNLSPEGCVAKITGLKNPVITGPARVFDSEDDAMSAIMDRRIRDGDVVVIRYEGPKGGPGMREMLAPTSALVGQGLGETVGLITDGRFSGGTWGMVVGHVAPEAFVGGPIALIREGDSVTIDAHQLLLQLNISDEEMAARRKAWAQPKPRYVRGVLAKFGKLACTASRGAVTDAFEE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase 2, DAD 2.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: VDAC2_XENLA
Sequence: AVPPSYADLGKSARDIFNKGYGFGLVKLDVKTKSATGVEFTTSGTSNTDSGKVNGSLETKYKWGEYGLTFTEKWNTDNTLGTEIAIEDQIAKGLKLTFDTTFSPNTGKKSGKVKAAYKQEYVNLGCDVDFDFAGPAIHGSAVVGYEGWLAGYQMTFDSAKSKLTKNNFAVGYKTGDFQLHTNVNDGSEFAGSIYQKVSDKMETAVNLAWTSGNNSTRFGIAAKYQLDSHAAISAKVNNSSLVGVGYTQTLRPGVKLTLSALVDGKNINAGGHKLGLGLELEA
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.  The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.  The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).
What are the official names of this protein?
Voltage-dependent anion-selective channel protein 2, VDAC-2, Outer mitochondrial membrane protein porin.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane.
Protein: RL27_ACTSZ
Sequence: MATKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGSNVGMGRDHTLFATADGKVKFEVKGEKSRKYVSIVTE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SYI_TROW8
Sequence: MCDQGEVSSQNSSDYKEQRPTPRPNLPKIEESVLAFWSSDKTFEASLEQRQHGKRWVFYDGPPFANGLPHFGHLLTGYIKDAIPRYQTMRGQYVPRVFGWDTHGLPAELEAMKRLGITEKSQIESMGIASFNEAARKSVLTYVDQWEEYVNRQARWVDFKNGYKTLDLDYMESVLWAFKTLYKKGVIYEGYKVLPYCWNDQTPLSNHELRMDDEVYKQRLDDSLTVTFPLIGQKAKTCGLDGVAALAWTTTPWTLPSNMALIVSPNVEYVVVSSARQNSNSDFLLCKSSLDSYAECLGYESGQDARASIRRTLLGKEIEGIHYKPLFDYYADLHNAFTILSDNYVDVTEGTGIVHASPAHGEDDKRVCDAFGVPTVVSINDAACFTDVISNYAGMHIFDANAVIRSDLSRDGRILRHESYKHSYPHCWRCRSPLIYKAVTSWFFRITDSVNRMLELNQQINWVPKSVKNGQFAKWLSSAKDWSISRTRYWGTPIPVWKSDNPEYPRIDCYGSLKELEDDFGIKLTDLHRPEIDRLTRPNPDDPTGASTMRRVPDVLDVWFDAASMPFAQLHYPFENIERFEANKSADFIVEYAGQIRGWFYLLHAMSTALFDGVAFKNAICHGIVLGDDGQKASKSLRNYPDVYDVFENEGSDAVRWYLISSSILRGGSLIVSRKKIQDAIRQYITPLWSSWYFFHIYSEAARPGGYKARFSVDSQDILDRYILSKTGLLVEDVTRFMDSFDMASAALQLRDFVAVLTNWYIRRSRDRFWDGSDTGAFDTLYTVLETLCRLGAVFVPMVSEHVYKCLTNSRSVHLSDWPDVATFPNETGLVETMDRVRKICSTGLSLRKRLGIKARQPLSSAHIRVAQVGSLAQYKDIISGELNVKTVSIEEGSCTQRMLKILPRVAGPRLAGDVQTVIAAARRGDWTDHDGHVTAGGIPLLENEYQLVAGAQDSKNSQPLPFGGSVTLDTRIDETLRSEGVARDTVRQIQIARKEKDLNITDRISLEVCVPDEQVKNNLLAFSELICKETLCDRLDILVKKGIDGITVSLEKFRQ
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBM6_YEAST
Sequence: MSANDYYGGTAGEKSQYSRPSNPPPSSAHQNKTQERGYPPQQQQQYYQQQQQHPGYYNQQGYNQQGYNQQGYNQQGYNQQGYNQQGYNQQGHQQPVYVQQQPPQRGNEGCLAACLAALCICCTMDMLF
What are the official names of this protein?
Uncharacterized protein YBR016W.
Protein: OPDH_PENO1
Sequence: MQFSSLSLVFLAVIGAIANPIAVDSELENRDVQLSKYGGECNLKTNACRYTKGGKSVFVPCGTAANKRCKSDRHHCEYDEHHKRVDCQTPV
What is the function of this protein?
Antifungal protein; part of the gene cluster that mediates the biosynthesis of oxopyrrolidines, polyketide-amino acid hybrid compounds with feature structures of tetramic acid (PubMed:36005526).  Acts as an inhibitor of growth of various molds and yeasts (By similarity).
What are the official names of this protein?
Antifungal protein opdH, Oxopyrrolidines biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the antifungal protein pafB family.
Protein: RL19_CHLTB
Sequence: MGNLIKELQDEQCRTDLADFCVGDTIRVATNISEGGKERVQVFQGTVMARKGGGAGETVSLHRVAYGEGMEKSFLLNSPKIVSIEVVKRGKVSRARLFYLRGKTGKAAKVKELIGSRAAKK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RL6_SALEP
Sequence: MSRVAKAPVVVPAGVDVKINGQVITIKGKNGELTRTLNDAVEVKHADNALTFGPRDGYADGWAQAGTARALLNSMVIGVTEGFTKKLQLVGVGYRAAVKGNVVNLSLGFSHPVDHQLPAGITAECPTQTEIVLKGADKQVIGQVAADLRAYRRPEPYKGKGVRYADEVVRTKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ILRUN_MOUSE
Sequence: MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIGAYYDFESPNISVPSMSFVEDVTIGEGESIPPDTQFIKTWRIQNSGAEAWPPGVCLKYVGGDQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWRMCTATGLYYGDVIWVILSVEVGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQKNRQSDENNLTDPGGSEFDSISKNTWAPVPEQSEQDQDRLSQSSVNLSPSSPANNLSVVTYSKGLHGPYPFGQS
What is the function of this protein?
Negative regulator of innate antiviral response.  Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF.  Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP.
What are the official names of this protein?
Protein ILRUN.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RNH3_LEUMM
Sequence: MQKVIQVNNQKLKQMAHYYSQFSSKKVPTGALFSISSGSATVTGYYSGKVMFQGKTASAEAAKWQSNSIHSLDTPKKMSTTLPADFANWSVLGSDEVGAGAYFGPLTTAAVYVSQENLEWVRALGIADSKTLTDDRMKKIAPQIIAKLPHHVVNLMPEKYNQLQPLHNVNQMKAISHNFALGKVLDKISPITPQAILIDQFAQQSTYFNYLKNAKQQRIIHENVYFTTKGEQYHLSVAAASILARVVELDAMSKLSVEAGIKLPIGAGREVDTVAAELLRRGIDLKHYAKLHFANTKKAERLL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_OCEIH
Sequence: MTFLAKILEEKQTEVNSRKQEKIDFGSRNIPVHSFIQLINQASSLSIIAEIKRASPSKGEIQMDIDPVEQAIKYEQAGASAISVLTDQRFFKGSLNDLQQVSEAVSIPVLCKDFIIDEIQIDDAKDAGASIILLILAALPLERFQELYNYATKQGLEVICEVHTAEELKNALTISPAIIGINNRNLKSFDVDLQTTKQLAQRVDTNKTIIISESGMRTASDATLAAESGAKAILVGETFMRSNQLETDFNNLRVPLVERSI
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: LPXC_SHIB3
Sequence: MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFIAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: FUT10_CANLF
Sequence: MVWIQRRRLLASCLCITATVFLLVTLQVVVELGKFERKKFKNSDLRAGHAKMEEEPVHLYPLPGKEALILKRKNQLETDSYPIMLWWSPLTGETGRLGQCGADECFFTINRTYLHHPMTKAFLFYGTDFNIDSLPLPRKAHHDWALFHEESPKNNYKLFHKPVITLFNYTATFSRHSHLPLTTQYLEGVEVLKSLRYLVPLRSKNNLRRRLAPLVYIQSDCDPPSDRDSYVRELMTYIEVDSYGECLRNKDLPQQLKNPASMDADGFYRIIAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPSIADWLPSNRSAILVSEFAHPRELANYIRQLDHDDRMYEAYIEWKLKGEVSNQRLLTALRERKWGVQDVHQDNYIDAFECMVCTKVWDNIRLQEKGLPPKRWKADVSHLSCPEPAVFAFSPLAPRWSSLREMWIPSFEQSKKEAQALRWLVDRNKNFSAQEFWALVFKD
What is the function of this protein?
Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.  Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation (By similarity).  Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity).
What are the official names of this protein?
Alpha-(1,3)-fucosyltransferase 10, Fucosyltransferase X, Fuc-TX, FucT-X, Galactoside 3-L-fucosyltransferase 10, Fucosyltransferase 10.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 10 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: THIO_PONAB
Sequence: MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFFKKGQKVGEFSGANKEKLEATINELV
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).  Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide.  Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.  Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway.