PharMolix/UniProtQA huggingface dataset:
Protein: ERB1_DEBHA
Sequence: MARNSKATDTPKTVVEKQSRKRKQDVEDAEESSSDEELQVEGILDDAASEDEESDSEDADKEDDEEEELEGDSDEEFNELLGEEEDLSDVDSEEFSDEPRDETASITDKLSGTKIRSYSNATEDEENEVHTKFSDGRPRIIKPEINPIYDSDDSDNENFNTIGNIPLSAYEEMPHIGYDINGKRIMRPAKGSALDQLLESIDLPEGWTGLFDQNTGTSLKITDDELELIRKIQAQESTDENINPYEPTIEWFTSKTEVMPLTAVPEPKRRFVPSKHEAKKVMKIVRAIREGRIVPPNKVKEQQEEEKYNFDLWNDNESETKDHIMNLRAPKLPPPTNEESYNPPEEYLMDEEEKKKWLEMEPEDRDKNYIPQKYNSLRKVPGYQEGLRERFERCLDLYLAPRTRHNKLNIDPDSLIPELPSPKDLRPFPIRCSTIFQGHTEKIRTLSISPDGLWLATGSDDGSVRIWEILTGRQVYKTVLVADDNTDDNIESLEWNPDSNSGILAAIAGEHIYLIVPPIFGFDIENNGRLRIESGWGYDTFGNKSKTKNSNIKVNSDDEDEEVEKADTNTGKKDVCKWFTPNTEQSQAGISAIIQCRKTVKKISWHRKGDYFVTVSPDSGHSSVLIHQLSKHLSQSPFKKSKGIIMDAKFHPFKPQLFVASQRYIRIYDLAQQVLVKKLMPGARWLSNIDIHPRGDNLLASSYDKRVLWHDLDLSSTPYKTLRYHDKAVRSIKFHKANLPLFASASDDGSIHVFHGTVYDDLMTNPLLVPLKKLTGHKIINSLGVLDLVWHPKEAWLFSAGADGTARLWTT
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein ERB1, Eukaryotic ribosome biogenesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: ATG12_SORMK
Sequence: MASPQPPFGGGSNSNSNTASPSNNLSPTASPLLEGRDSPNLPLTMTASTVLMTLPRDATAALAEAGKFGQEKVVIRFKPVGSAPALRREQVKVSSTERFDTVMTYIRKTLKCRESDSVFLYVNSVFAPALDEVVGNLWRCFKDSTNQLNVSYSMTPSFG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy (By similarity).  Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function (By similarity).  The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (PubMed:27309377).  ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity (By similarity).  Plays a role in sexual development and perithecia formation (PubMed:27309377).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm. Note=Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre-autophagosomal structure (PAS) (By similarity). Ultimately, the IM expands to become a mature autophagosome (By similarity). Localizes also to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole- IM contact site (VICS) (By similarity).
Protein: RISB_YERP3
Sequence: MNVIEGVVATPNARVAIAIARFNNFINDSLLDGAIDALKRIGQVSDDNITVVWVPGAYELPLVANVLAKTNRYDAVIALGTVIRGGTAHFEYVAGEASSGLSSVAMNSDIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVIKAIKG
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: ADHA_CLOAB
Sequence: MLSFDYSIPTKVFFGKGKIDVIGEEIKKYGSRVLIVYGGGSIKRNGIYDRATAILKENNIAFYELSGVEPNPRITTVKKGIEICRENNVDLVLAIGGGSAIDCSKVIAAGVYYDGDTWDMVKDPSKITKVLPIASILTLSATGSEMDQIAVISNMETNEKLGVGHDDMRPKFSVLDPTYTFTVPKNQTAAGTADIMSHTFESYFSGVEGAYVQDGIAEAILRTCIKYGKIAMEKTDDYEARANLMWASSLAINGLLSLGKDRKWSCHPMEHELSAYYDITHGVGLAILTPNWMEYILNDDTLHKFVSYGINVWGIDKNKDNYEIAREAIKNTREYFNSLGIPSKLREVGIGKDKLELMAKQAVRNSGGTIGSLRPINAEDVLEIFKKSY
What are the official names of this protein?
NADH-dependent butanol dehydrogenase A, BDH I.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
Protein: RS15_PELPD
Sequence: MLATEKKQEIIKAFKKHDSDTGSPEVQIAILTERITYLTEHFKVHKKDHHSRRGLLKLVGQRRRLLDYLKGKEVARYKAVIERLGIRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PUR5_SALPC
Sequence: MTDKTSLSYKDAGVDIDAGNALVDRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPVLVSGTDGVGTKLRLAMDLKRHDAIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTAASVINGIAEGCLQSGCALVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSRVAEGDVLIALGSSGPHSNGYSLVRKIIDVSGCDPQTTLLEGKPLADHLLEPTRIYVKSVLELIENIDVHAIAHLTGGGFWENIPRVLPENTQAVINESSWQWPAIFTWLQTAGNVSRHEMYRTFNCGVGMVIALSAPEADKALALLNEKGENAWKIGIIKASDSEQRVVIE
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_SHESM
Sequence: MFRGASAINLDTKGRIAIPVRYREPLQLEHQGRIVITVDIQSACLLLYPIHEWELIEAKLLKLSDTDKTQRSLKRMLLGYAHEVELDGNGRILLPPPLRQYANLDKRIMLVGQLNKFELWDEQAWLQQIDECQETIRSEELANNERLADFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: HEK2_CANGA
Sequence: MPVSHRILLSLKEAAKVIGTQGNSIQSVRDNNNNVKIGISEKVPGCSDRVLTCSGEVEDVCSALGDVVTLLNKPSENEEETDNHHFYFLNHLLPVPTLDDLKATDPEASEEALHEQLQNIGYLRLLVFNSQLSSIIGKGGNQIKSLIEKHGVKLVASRAFLPDSTERMLEIQGVPSAIKQVLLDICEIIAKEEEEEEKARAENNNGESTGRKRFERKYYPHLQRNNTNSSSNNGSVGNSANSQEYTATVMIPESYVGALAGKKGNRLANLRKFTKTKILMESRPNDLDNEHEDENDMEEDDGRLRKFTIIGSSSRSVNLAESMLQRNLATEIERRKERLRNLSENNESA
What is the function of this protein?
RNA-binding protein involved in the correct localization of transcripts in the cell.  RNA localization is a widespread mechanism for achieving localized protein synthesis.  Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus (By similarity).
What are the official names of this protein?
Heterogeneous nuclear rnp K-like protein 2, KH domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the HEK2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body. Nucleus. Chromosome, telomere.
Protein: VANG2_DANRE
Sequence: MDNESQYSGYSYKSSHSRSSRKHRDRRDRHRSKSRDSSSRGDKSVTIQAPGEPLLDAESTRGDDRDDNWGETTTVVTGTSEHSVSNEDLTRASKELEDSSPLECRRFAGPIVSGVLGLFALLTPLAFLLLPQLLWRDSLEPCGTPCEGLYVSLAFKLLVLLISSWALFLRPSRSTLPRFFVFRCLLMALVFLFVASYWLFYGVRVLEPRERDYRGIVGYAVSLVDALLFIQYLALVLLEVRHLRPAFCLKVVRTTDGASRFYNVGHLSIQRAAVWVLDHYYTDFPVYNPALLNLPKSILSKKMSGFKVYSLGEENSTNNSTGQSRAMIAAAARRRDNSHNEYYYEEAEMDRRVRKRKARLVVAVEEAFTHIKRLQDDEAAASPKHPREVMDPREAAQAIFAPMARAMQKYLRTTRQQPYHSMESIISHLQFCITHNMTPKAFLERYLTPGPTMQYQRENGRGRQWTLVSEEPVTAALRQGLVFSLRRLDFALVVTVTPLPFLNLGEEFIDPKSHKFVMRLQSETSV
What is the function of this protein?
Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation.  Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane.  Has an overlapping role with kny during both convergent extension and eye development.  In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh.  Has indirect effects on a number of other developmental processes including notochord shape formation, neural progenitor cell morphogenesis, segregation of somites and adaxial cell development.  Together with prickle1, required for the posterior (caudal) movement of branchiomotor neurons in the hindbrain independently of, and a few hours after, convergent extension (PubMed:11780127, Ref. 2, PubMed:9007230, PubMed:9007234, PubMed:9007236, PubMed:9808788, PubMed:10996075, PubMed:10992326, PubMed:11820812, PubMed:12105418, PubMed:12874125, PubMed:15829519, PubMed:16407953, PubMed:17239849).  May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity).
What are the official names of this protein?
Vang-like protein 2, Protein strabismus, Protein trilobite, Van Gogh-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the Vang family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YER90_YEAST
Sequence: MESIILSIAIFIGVLLGTSVGTFSGSGISAGVGASSGSGISAGVGASSGSSTSVGVGTFGGSSTSVGVGTFGGSSTSVGVGTFSGSRTSPDVDAGSGSSTSPDVGAGSGSSISAGVGTFSGSRTSPDVDAGSGSSTSPDVGAGSGSSISAGVGSRIGTGISTTMNARVAVLITAAILSAPVTAIALLEARR
What are the official names of this protein?
Putative uncharacterized protein YER190C-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PSBJ_NICSY
Sequence: MADTTGRIPLWIIGTVAGILVIGLIGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PTGA_HAEIN
Sequence: MGLFDKLFGSKENKSVEVEIYARISGEIVNIEDVPDVVFSEKIVGDGVAVRPIGNKIVAPVDGVIGKIFETNHAFSMESKEGVELFVHFGIDTVELKGEGFTRIAQEGQSVKRGDTVIEFDLALLESKAKSVLTPIVISNMDEISCIVKKSGEVVAGESVVLALKK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II complex composed of PtsG and Crr is involved in glucose transport.
What are the official names of this protein?
PTS system glucose-specific EIIA component, EIIA-Glc, EIII-Glc, Glucose-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEL3B_HUMAN
Sequence: MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISSSRTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
What is the function of this protein?
Efficient protease with alanine specificity but only little elastolytic activity.
What are the official names of this protein?
Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Elastase subfamily.
Protein: B2L15_MOUSE
Sequence: MSKMKNPRTFEEQTECIVNSLLKDFRTPLSHAANRNLSGADEPCSGEDYSFDVAIIVGRLRILGDQFNGELEASANNIIAVTIGGQAGSTVLNDTVQSLSRTWCTQDPTLVFERAFLAVSVKLLEYVVRKAPNVARQVANYVTGMINGNTAIREFIQGQGGWENLES
What are the official names of this protein?
Bcl-2-like protein 15, Bcl2-L-15, Bcl-2 family kin, Bfk.
Protein: SK1_DIPPU
Sequence: EQFEDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, DipPu-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: KATG_KLEP7
Sequence: MSTSNDPSNNASAGKCPFHAETPKQSAGSGTANRDWWPNQLRVDLLNQHSNRSNPLGENFNYREEFKKLDYSALKADLRALLTDSQEWWPADWGSYIGLFIRMAWHGAGTYRTVDGRGGAGRGQQRFAPLNSWPDNVSLDKARRLLWPVKQKYGQKISWADLYMLAGNVALENAGFRTFGFGAGREDVWEPDLDVDWGDEKEWLAHRHPESLAKQAIGATEMGLIYVNPEGPNASGEPLSAAAAIRATFGNMAMDDEEIVALIAGGHTLGKTHGAAETSHVGAEPEAAPLEAQGLGWHSSYGSGAGADAITSGLEVVWTQTPTQWSNYFFENLFKYEWVQTRSPAGAIQFEAKDAPEIIPDPFNPEKKRKPTMLVTDLTLRFDPEFEKISRRFLNDPQAFNEAFARAWFKLTHRDMGPKSRYLGPEVPKEDLIWQDPLPAATHQPSAEDIASLKTAIAGAGLSVSELVSVAWASASTFRGGDKRGGANGARLALAPQKDWPVNAIASRVLPTLQAIQRASGKASLADIIVLAGVVGVEQAAAAAGVSVNVPFTPGRVDALPEQTDVESFDLLQPLADGFRNYRRIEGGVSTETLLIDKAQQLTLTAPEMTVLVGGLRVLGANYDGSKHGVFTDRVGVLSNDFFVNLLDMATVWKAADDNAELFTGSDRKTGEAKYSATRVDLVFGSNSVLRALAEVYACADGQQKLVHDFVAAWTKVMNLDRFDL
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: NAGB_BACFN
Sequence: MRLIIQPDYQSVSQWAAHYVAAKIKAANPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKEHPESYYSFMWNNFFSHIDIKPENTNILNGNAADLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLSSRTRQKTLTTDTIIANSRFFDNDINKVPKTSLTVGVGTVLSAREVMIIVNGHNKARALYHAVEGAITQMWTISALQMHEKGIIVCDDAATAELKVGTYRYFKDIEADHLDPQSLLK
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: NB1_MYCA1
Sequence: MTSPESSSAAGSGDRAVAAAAERAKLTAGRNIPSFDDLPLPADTANLREGADLSDALLALLPLVGVWRGEGEGRGHDGDYRFGQQIVVSHDGGDYLNWEARSWRLNETGDYQERGLRETGFWRFVRDPDDPSESQAIELLLAHSAGYVELFYGRPRTQSSWELVTDALARSRSGVLVGGAKRLYGIVEGGDLAYVEERVDADGGLVPHLSARLSRFAG
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase 1, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: RT106_CANGA
Sequence: MSSFDFLNELPKELQNKIRNITRALPSSLEVFQELYNYGLSHSDNIEKKRKVTSNGVIDEQNIIFSLKNVSVLSPIRKKLDLVLHLSSIDHKPQLSLVKNGVSEFSISNLKDNVKMGTFLPVPEKPNLLYLFVQLKKVNDKDQDPILLTMNKENVLTEFKSMGLIGQEVDDFNKCTEYIRKQAILTGFKIANPFNPSVEQPVPSFHVECHRGTKEGTLYFLPEIIIFGFKKPILVFESSNIESISYSSITRLTFNVTLIKKVDDGYGTKFEFSMIDQTEYSKIDDYVKLKQVKDESMSEELKAKTANKNKQQNNTSDQPSALQEATKQMETEGNINEIPFDSEDDEEADGNFEDNSDLSDGSEVEEEDNEEENEEDEEADGGDYAEEDFEEDEIIQEQANPAVNQLISKTTPINKNSSNAGLFDFPIETPSFDIPIELEDNEDDEEGSGVEYD
What is the function of this protein?
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing.  Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA.  Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
What are the official names of this protein?
Histone chaperone RTT106.
What is the protein family that this protein belongs to?
Belongs to the RTT106 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: HPF_AZOVI
Sequence: MQVNISGHQLDVTDALRDYVEEKISRLERHFDRITSVQVIMTVEKLKQKIEATLHVSGAEVVANAEHEDMYAAIDLLADKLDRQLIKHKEKQIERQQGQRPADSPVP
What is the function of this protein?
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
What are the official names of this protein?
Ribosome hibernation promoting factor, HPF, Hibernation factor HPF.
What is the protein family that this protein belongs to?
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Protein: BIOA_STRCO
Sequence: MPDPALNVAELLDLDRRHVWHPYGPMPGRQDPLVVESASGVRLRPADGSGELVDGMSSWWSAIHGYNHPVLNAAAREQLERMSHVMFGGLTHEPAVRLAKLLVDMSPEGLEHVFLADSGSVSVEVAVKMCLQYWRSLGRPGKHRLLTWRGGYHGDTWQPMSVCDPEGGMHELWSGVLPRQVFADAPPAEYEETYADHLRSMVERHAGELAAVIVEPVVQGAGGMRFHSPAYLRVLREACDAHDVLLVFDEIATGFGRTGALFAAEHAAVTPDVMCVGKALTGGYLTMAATLCTSRVAEGISRGEVPVLAHGPTFMGNPLAAAVACASIGLLLGQDWLAEVKRIETGLGEGLAPAAGLPGVRDVRVLGAIGVVQLDHAVDMRAATKAAVREGVWLRPFRDLVYTMPPYVTGDADVARIARAVCAAAREG
What is the function of this protein?
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA).  It is the only aminotransferase known to utilize SAM as an amino donor.
What are the official names of this protein?
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, 7,8-diamino-pelargonic acid aminotransferase, DAPA AT, DAPA aminotransferase, 7,8-diaminononanoate synthase, DANS, Diaminopelargonic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSH3_NEOFI
Sequence: MTLSSSQSSPPSSQNLKRKQQTISSFFTKRAPTAEKRSNDLEDGRATTQKGAEMPLRETTGDQDDLVDDEDGDIVVRAPKRVKTNRVDPENGFGRNVTRGPDPPSSSSQRTNLCKFASSPADDAGIEKADDPEARQRQLEREKLHKLFVKKLGGADCLIGIGRNATTEAPSGTEEVAEGDEDDESAPPPRSKGKGASKKGGSKLTPLEKQVIEIKRKHMDTVLVIEVGYKFRFFGEDARIAAKELSIVCIPGKMRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVSAGYKVGVVRQLETAALKAVGDNRNAPFSRKLTNLYTKGTYVDDVEGLDGATPAASGGASPATGYMLCITETNAKGWGNDEKVHVGIVAVQPNTGDIIYDDFEDGFMRSEVEARLLHIAPCELVIVGELSKATEKLVQHLSGSKLNTFGDKVRVDRVAKKKTAVAESHSHVANFYAAKLKAANTADDAPASNLLQKVLNLPEQVTVCLSAMIEHLTEYGLEHIFELTKYFQHFSSRSHMLLNANTLVSLEIYQNQTDHSAKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKERLEERVNAVEELKSPDRTVQVERLKILLGRIKSDLEKNLIRIYYGKCTRPELLTVLQTLQTIAQEYVDVKTPEDSGFTSPILGEAIARVPSILEDVVKFLNKINMHAARNDDKYEFFRESEETEGISEHKCGIASVEHELEEHRSVAAGILKWPKVTYVTSSGIEYLIEVENTAAAIKRVPASWVKVSGTKKLSRFHTPEVIQLLRQRDQHKEALAAACDQAFAALLAEIATNYQSFRDSVQSLATLDCLLSLAAIASQPGYVKPEYTDQTCIHVEQGRHPMVEQLLLDSYVPNDIDLDSDRTRALLVTGPNMGGKSSYVRQIALIAIMAQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRTIRSLTLFITHYQHLSNMAQSFPNHELRNVHMRFTESGSGKDEEITFLYEVGEGVAHRSYGLNVARLANLPAPLLEVARQKSSELEERIRRRRLAGLRADVGGLMEDPAKGDEDFFQRLISNAEQL
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  Msh3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein msh3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MEN1_RAT
Sequence: MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGSNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYQDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVHIVSREAEAAEAEEPWGDEAREGRRRGPRRESKPEEPPPPKKPALDKGPGSGQSAGSGPPRKTSGTVSGTARGTEVSSAAQAPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL
What is the function of this protein?
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4).  Functions as a transcriptional regulator.  Binds to the TERT promoter and represses telomerase expression.  Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA.  Positively regulates HOXC8 and HOXC6 gene expression.  May be involved in normal hematopoiesis through the activation of HOXA9 expression.  May be involved in DNA repair (By similarity).  Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity.
What are the official names of this protein?
Menin.
What are the subcellular locations of this protein?
Nucleus.
Protein: VDR_PIG
Sequence: MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYADFGQFRPPVRGDEEEGTLPSRSSSAHAPSFSGSSSSSCSDQYTSSPDTMEPASFSHLDLSEEDSDDPSVTLDLSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIVLLKSSAIEVIMLRSNQSFTMDDMSWTCGSRDYKYQVSDVAKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDPTLIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
What is the function of this protein?
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells.  Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR.  The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity).  Plays a central role in calcium homeostasis (By similarity).  Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity).
What are the official names of this protein?
Vitamin D3 receptor, VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand- independent pathways; ligand-independent nuclear translocation is mediated by IPO4.
Protein: RS8_PSET1
Sequence: MSLQDPIADLFTRIRNGQSAKKVSVTMPNSKLKVAVAKVLKNEGYIADFAINGDVKPELSIELKYFEGKAVIENIQRVSRPGLRIYKRRDELPKVMGGLGIAIVSTSKGLMTDRAARSAGVGGEIIGFVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.