PharMolix/UniProtQA huggingface dataset:
Protein: TRM4B_SCHPO
Sequence: MGKRNKKVTQGKRAYNDKSEIVLENKQFEGYYKKQNLFRGKPNDEFDSFMEYMRKPLPTTFRICGYRHHAFELKNHFEKYYVPSLKNVVHEGQTIPPPTVLPWYPDGLAYIVDAQKDVIRKSPPLKRLQRFLVSENEAGNINRQEAVSMLPPLFLDVEPHHVILDMCAAPGSKTAQLIEAVYKKANIKDAAHDSKNLKSVEGLVIANDADPKRAQMLVHQINRLNSPNILVVNHDASTMPNIYVKGSSPSDGLNVIEEKKILKFDRILADVPCSGDGTFRKNLSLWREWSANSAFSLHPLQLRILIRGLQLLKVGGCLVYSTCSINPIENEAVVTAALKATGGAVSLVDVSKKLPLLKRDPGLLSWKVLDDSLNEFQSPAENTNDKIELTESMWPLPEEEMSKLHIERCARLYPHMQNTGGFFVAVLQKTDPINSRSFDPKKYTASMEILPPENKRQRTEKGVDEASNSTLTKSGNSYFDEEPFVYINPDDTSIKTIVDFYGIDPSFPRDQFFVRNQSGIPVRSIYFACSLFKEIIEANTNRVKFVHGGVRFFVKQEISQLLKDFSLKANKDICNFRIHSNGVNIISPFLNEKHFYDAGLKDLKILVKNEYPHVEQFSESGMLKKEFEKMPLGCNILRVDAQTKDGALMDMLILQPIWRSPTSCNLMLARKEKQNLSLELFGMDV
What is the function of this protein?
tRNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in tRNAs at position 49 and 50 (PubMed:30646830).  Trm4a and trm4b methylate different sets of tRNAs (PubMed:30646830).  Also methylates cytosine to m5C at positions (60, 61 and 62) in tRNA(Asp) (PubMed:23074192).
What are the official names of this protein?
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4b, tRNA (cytosine-5-)-methyltransferase trm4b.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS5_XANOM
Sequence: MTDVALIDAGGANLGSVRYALERLGVEARVVRDAAGLQGAQRVILPGVGAAPEVMSRLRAQGLVAPLRELQVPLIGICLGMQLLFEHSEEGDVECLGLLPGIVRHMTPALGIRVPHMGWNRLVPMRESALLAGLPERASAYFVHGYAAPVTADTVAACDHGGLFTAIVQNGLRCGAQFHPERSADTGARILHNFLEMSFP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRDD_SHIB3
Sequence: MINPNPKHSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGIVTI
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTH_STRGC
Sequence: MTKLIVGLGNPGDKYFETKHNVGFMLVDKLCKDLNLKFTVDKIFQSEIASTFLNGEKIYFIKPTTFMNESGKAVHALLTYYGLEVEDLLVIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIKHIGTQDFKRVKIGIGRPKEGMTVVHHVLGKFDRDDYITILNTLDKVDNAVNYYLQSGNFEQAMQKYNG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_TERTT
Sequence: MAEPITLARPYAKAAFEAARDASALQSWSDALVEAAAITRDSKVKALLSSPSLTAVQKAAAFIDLCGDTLNEAQKNFIRVLADNNRLPLFPQVSQLFELYKANQEKAVDVELQTAYDIDDAVLAKLATSLTEKLDRKVSLQTAIDPSLLGGAIIRAGDTVIDGSVRGRLAKLAETMSH
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GATA_MYCPN
Sequence: MKSQILKLQQTLTKKPASINPLLQQIDGAINEHWSSNFLLKNTVEWAQAQAPKNRSKSPLNNIPFVLKDNIATKGIVTTGGSRFLEDYIPPFSATVFELLNNSGALLVGKANLDEFGLGGTGLHSGFGFVHHPWNETLIPGGSSSGSAYAVARGIVPFSIGTDTGDSVRRPASICNIVGFKPTYGLISRNGVYPYAPSLDHVGIFARYVYDVALVSDEIIKHDKADFSAQKSPDAGKFTRSLKESFNKQIKIGYLKPLEEWFDIELSKKWNSLKERITLEGCELIPFHFPLELLEVIDPVYKLISYSEAVSCYSNLTGIVFGQKLFEPNQASDFSKTITANRDRFFGEQLKRRFIIGAFGTDKNNFTKYFEKAQKIRRVMVDAYLNLFKEADFIVSPSASGFTKTIAAVQKGESFTNLVDDFLQLANFAGNPSITIPWLVKQKDQTIGLSVNANCFHDKQLLQVAAWLEELFQIEHDD
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: ANMK_GLOC7
Sequence: MYCIGLMSGTSVDGIDAALVNISGKDLDLHIELIAGATYPYPPALREKIIAVSEGVSLSMVELAQLDDAIATQFALAAQKIQKGHPQAELIGSHGQTIYHRPPKIKRGEFSQTDLGYSLQLGRGEVITDLTGIPTVSKFRIADIAAGGQGAPLVPKVDAYLLSHPTQTRCIQNIGGIGNVTYLPPRNQENWESHVYGWDTGPGNVLIDLAVQKLTNGQKTYDENGEWAAQGKPSQDLVTKWLQYDFFYQAPPKSTGRELFGHEYLDKCWTDAIALQLPPEDFLASLVELTVASIIHNYRAFLPQMPQAVLLCGGGSHNLYLKQRLQENLGHQSQVLTTDEVGINGDYKEAITFAVLAYWRKICSFPGNLPQVTGASKPMLLGDIHLPISQI
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RF1_PARPJ
Sequence: MKTSMQRKLDQLTTRLAELNDLLSREDITSNLDQYRKLTREHAELGPVVDHYALWRQAMNDATTAQELLADASMRDFAEDEIRAARERMEKLGAELQKMLLPKDPNDDRNIFLEIRAGTGGDESALFAGDLLRMYLRFAERNRWQVEMMSASESDLGGYKEVIVRIAGEAAYSKLKFESGGHRVQRVPATETQGRIHTSACTVAVMPEADEIGEVEINPADLRIDTFRASGAGGQHINKTDSAVRVTHLPTGIVVECQDDRSQHKNKDRALKVLAARIKDKQSHEQQAKEAATRKSLIGSGDRSERIRTYNFPQGRLTDHRINLTLYRLDAIMDGDLDELIAALVSEHQAELLASLGDAD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BACR1_HALWD
Sequence: MSQLALQMSSLGVEGEGIWLALGTIGMLLGMLYFIADGLDVQDPRQKEFYVITILIPAIAAASYLSMFFGFGLTEVSLANGRVVDVYWARYADWLFTTPLLLLDIGLLAGASQRDIGALVGIDAFMIVTGLVATLTKVVVARYAFWTISTISMVFLLYYLVAVFGEAVSDADEDTRSTFNALRNIILVTWAIYPVAWLVGTEGLALTGLYGETLLFMVLDLVAKVGFGFILLRSRAIMGGGSEPTPSAQETAAD
What is the function of this protein?
Light-driven proton pump.  The chromophore contains 78% all-trans- and 22% 13-cis-retinal in the dark and 90% all-trans- and 10% 13-cis-retinal upon illumination with >500 nm light.
What are the official names of this protein?
Bacteriorhodopsin-I, HwBR, Squarebop I.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GSA_DESPS
Sequence: MESLKSKKLFAEAKKVIPGGVNSPVRACLSVGCDPLFIERAEGSYIYDADGQKYLDFVNSWGPMIMGHAHPDIIKAIQDAAVYGTSYGAPTSSEVDLASMVVEAVPSIEKVRFVSSGTEATMSAVRLARGYTGKNVIVKFDGCYHGHADSFLVKAGSGVLTLGIPGSPGVPEDIVKNTISIPYNSVEALETTLRDADLNIACVIVEPVAGNMGCVPPAPGFLQKLREITAEEGIVLIFDEVITGFRLSYGGAQQYYGVTPDLTCLGKIIGGGLPVGAYGGKADIMNSVAPDGPVYQAGTLSGNPLAMAAGKAALKLLQQDGFYEDLNQKSAAYADGLLEVAGRVGLPMQLNRVGSVMTSFFTATPVTDFETAMKADTGLYGRHYRQMLDSGIYLAPSQFECSFMSSTHSDADLKRALLETEKSFSLLKNA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC186_MOUSE
Sequence: MKIRSRFEEMQSELVPVSMSETEHIASISSDATTEKTSELRDDSCISVSGDESSRLETGAELLSLDSDRILCQTNEHCSQIEVQESHIPDCGSGENSCANTDTCPEDSGQIDDFPGGDFTEQVSKTKEPEQTVTQILAELKSSAPAEAANPKTASASLYDTDCTRKLISEMKTVSASDDLLGEIESELLSAEFAEGHQVPNGLNKGEQALALFEKCVHSRYLQQELTVKQLIKENKNHQELILNICSEKDSLREELRKRTETEKQHMNTIKQLELRIEELNKEIKASKDQLVAQDVTAKNAIQQIHKEMAQRMDQANKKCEEARQEKEAMVMKYVRGEKEALDLRKEKETLERKLRDASKELEKNTNKIKQLSQEKGRLQQLYESKEGETTRLIREIEKLKEEMNSQVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAEQIRQNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKAKCLEDERLRTEDELSKYREIINRQKSEIQNLLDKVKITDQLHEQLQSGKQEIEHLKEEMESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESSALQSQVDNLSCTESQLQSQCQQMGQANRNLESKLLKEEELRKEEVQTLQAELSAAQTEVKALSTQVEELKDELVTQRRKHASNVKDLSKQLQQARRKLEQTENGNHDKDISSMGSRSSSSGSLNARISAEDRSPENTSSSVAVDNFPEVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKA
What are the official names of this protein?
Coiled-coil domain-containing protein 186, Oocyte-testis gene 1 protein.
Protein: YMAE_BACSU
Sequence: MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLEDMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTIDQINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETLNMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLIPLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT
What are the official names of this protein?
Uncharacterized protein YmaE.
Protein: Y615_BACC7
Sequence: MGRKWNNIKDKKASKDANTSRIYAKFGREIYVAAKQGEPDPESNQALRVVLERAKTYNVPRTIIDRAVEKAKGGSEENYDELRYEGFGPNGAMVIVDTLTNNVNRTAADVRAAFSKNGGNMGVNGSVAYMFDATAVIGLEGKTSDEVLEILMEADVDVRDILEEEDAVIVYAEPDQFHAVQSALKDAGVEEFTVAELTMLAQNDVTLPEDAQAQFEKMVDALEDLEDVQQVYHNVDLGE
What are the official names of this protein?
Probable transcriptional regulatory protein BCAH187_A0615.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family. YeeN subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_MESH2
Sequence: MEKQENVGHIVQIFGPVIDVQFPNEHMPAILSALEVKINDESIIFEVAQHLGEGIVRAIAMSMTYNLSKGLEVYDTGSQISVPVGKQVLSRMFNVLGQPIDGGKPLDSFIKNPIHANAPTYLEQKATSEILVTGIKVIDLLIPFIKGGKIGLFGGAGVGKTVLVQELINNIASKHGGLSVFAGVGERSREGNDLYFEMKKAGVLDKTALVFGQMNEPPGARMRVALSALTMAEYFRDYENQDVLLFIDNIFRFTQAGSEVSTLLGRIPSTVGYQPTLSTEMGQLQERITSTIRGSITSVQAVYVPADDITDPAPATTFSHLDAKTVLDRGIAALGIYPAVDPLASSSRALEPNIVGKKHYLVAKKVVQILQRFKELQDIIAILGVDELSESDKQVVARARRIRNFLSQPFFVAQKFSGIQGQFIKIQDTVNNFDELLSGKYDNIPEEAFLYVGTIDQALEKAKKMGWSEKN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LPXH_KLEP3
Sequence: MATLFIADLHLQTEEPAITAGFLRFLQGEARQADALYILGDLFEAWIGDDDPNPLHQQIASAIKAVVDAGVPCYFIHGNRDFLVGQRFARQSGMLLLAEEERLDLYGREVLIMHGDTLCTDDQNYLAFRAKVHTPWIQRLFLALPLFIRRRIAARMRADSKAANSSKSMDIMDVNPQAVVDVMERHHVQWLIHGHTHRPAVHELQANGQPAWRVVLGAWHSEGSMVKVTPDDVELIHFPF
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PANT_LEUMM
Sequence: MSNNKTKYLVITTFFMAIILLQVLIPWLGYIPLGAVIVGAQPTIIQFTVAIAAILLGARRGAFIGGFWGLLTLWQAWSTPGSIGSLMFQNPFTAFIPRILVGLIIGMAFNKWLRNKNFGFRTLGLGFLGGLAALINTVGVVLLTVIGFTVMRTNFTGIPNHNLLGWLIGIVSFNSIFEIITGIILVAAIGNVLVPIAERAGIKG
What is the function of this protein?
Probable pantothenate-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.  The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins and transport it into cells.  Upon coexpression with its energy-coupling factor (ECF) ABC-transporter complex EcfA1A2T in E. coli allows pantothenate uptake; uptake requires both PanT and EcfA1A2T.
What are the official names of this protein?
Pantothenate transporter PanT, Pantothenic acid ECF transporter S component PanT.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: I4OMT_MEDTR
Sequence: MAFSTNGSEESELYHAQIHLYKHVYNFVSSMALKSAMELGIADAIHNHGKPMTLSELASSLKLHPSKVNILHRFLRLLTHNGFFAKTIVKGKEGDEEEEIAYSLTPPSKLLISGKPTCLSSIVKGALHPSSLDMWSSSKKWFNEDKEQTLFECATGESFWDFLNKDSESSTLSMFQDAMASDSRMFKLVLQENKRVFEGLESLVDVGGGTGGVTKLIHEIFPHLKCTVFDQPQVVGNLTGNENLNFVGGDMFKSIPSADAVLLKWVLHDWNDEQSLKILKNSKEAISHKGKDGKVIIIDISIDETSDDRGLTELQLDYDLVMLTMFLGKERTKQEWEKLIYDAGFSSYKITPISGFKSLIEVYP
What is the function of this protein?
2-hydroxyisoflavanone 4'-O-methyltransferase involved in the biosynthesis of the phytoalexin medicarpin.  Has also an in vitro (+)-6a-hydroxymaackiain-3-0-methyltransferase activity, converting the pterocarpan 6a-hydroxymaackiain into pisatin.  No activity with di- or trihydroxylated isoflavones, including daidzein and genistein, or with (-)-medicarpin and maackiain.  The dual activity for either 3- or 4'-O-methylation depends upon substrate availability.
What are the official names of this protein?
Isoflavone 4'-O-methyltransferase, MtHI4'OMT, 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: SSRP_GRAFK
Sequence: MYFCGYMKNSINIKNRKAKFNYEFLDKYTAGIKLAGTEIKAIREGKANIAESFCEFNNHELFVINMHVEEYSHATHFNHNPRSQRKLLLQRRELRKLEKEVTNSGLTIIPLRLFINDRGLAKLQISLAKGKKLYDKRETIKDRESKRRLDRIQKEYK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SINL5_ARATH
Sequence: MARSGGNDGHEEELDPELFEEPSNLEGYEDGEFEEDEEEFEEEEEELEEEEDEEEEEEENVTTDEQSGSPKSSQPVKLQSSDVLDCPTCCEPLKRPIYQCSNGHLACSSCCQKLNKKCSFCRCNIGDIRCRAMEKVIEASIVPCPNAKHGCKETTTYCNQSSHEKVCKFVRCSCPVSNCNYVSSYSNLKSHACSTAHVWGEDDIHFQLVIDRPRIFNMNLGRKKTVVFKEEKEGDLIVVQAFKGLEGVYVTVNRIAHMAPGIRDLSCSLAKLNEYSTLRSGSLVKKIQKVREKMHLEDDLMWIPPKMLSGDHWKMQICIAYGYKFIHI
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  It probably triggers the ubiquitin-mediated degradation of different substrates.
What are the official names of this protein?
E3 ubiquitin-protein ligase SINA-like 5, RING-type E3 ubiquitin transferase SINA-like 5, Seven in absentia-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the SINA (Seven in absentia) family.
Protein: YHBQ_ECO55
Sequence: MTPWFLYLIRTADNKLYTGITTDVERRYQQHQSGKGAKALRGKGELTLAFSAPVGDRSLALRAEYRVKQLTKRQKERLVAEGAGFAELLSSLQTPEIKSD
What are the official names of this protein?
UPF0213 protein YhbQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: ITPA_VITVI
Sequence: MAAAGASASGLILSRPVTFVTGNAKKLEEVRYILGQSIPFNSLKLDLPELQGEPEDISKEKARLAAIQVNGPVLVEDTCLCFNALKGLPGPYIKWFLQKIGHEGLNNLLMAYEDKSAYALCAFSFALGPDAEPVTFLGKTPGKIVPPRGPNDFGWDPIFQPDGYEQTYAEMPKEEKNKISHRYKALALVKSHFAKAGYVFQTDSPI
What is the function of this protein?
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_SHESR
Sequence: MKTPIELKILDSRIGSEFPLPAYATLGSAGMDLRAMIDTTMTIAPGETQLIPTGIAIHVADPGLAAVLLPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRSDIPFTLEIGDRLAQLVFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: YIHI_VIBVU
Sequence: MSRKKKSRKPGAAGAPEFMVTRNRSESDVAGRLRKKDKKRKGLKAGGRNSEEGAQQKHGSSQVRDPRLGSKKKIPLIVEPAKKLTKQERRLSAEQELEMLENDAKLNVLLDRIESGENLGRGLQQYVDEKLDRIEQLMSQLGLLEPEAEEEFEEEAPVRKSRSDDDLLADFEDFDMDDYKG
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: SIA4A_MOUSE
Sequence: MRRKTLKYLTFFLLFIFLTSFVLNYSNTGVPSAWFPKQMLLELSENFRRFIKSQPCTCRHCISQDKVSYWFDQRFNKTMQPLLTVHNALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVPGNVDPMLNKRLVGCRRCAVVGNSGNLKDSSYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKTTDLQWVISATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSIIFSIHICDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDGDFEYNITTTLAAINKIRIFKGR
What is the function of this protein?
A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8375377, PubMed:9184827).  Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8144500, PubMed:8375377, PubMed:9184827, PubMed:10755614).  Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans.  As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45.  Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (PubMed:10755614).  Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8375377).  Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8144500, PubMed:8375377, PubMed:9184827).
What are the official names of this protein?
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1, Alpha 2,3-ST 1, Beta-galactoside alpha-2,3-sialyltransferase 1, Gal-NAc6S, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, Monosialoganglioside sialyltransferase, ST3Gal I, ST3GalI, ST3GalA.1, ST3O, Sialyltransferase 4A, SIAT4-A.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in medial and trans cisternae of Golgi (By similarity). Secreted into the body fluid.
Protein: EFTU_HAMD5
Sequence: MSKEKFERKKPHINVGTIGHVDHGKTTLTAAITTVLSKKYGGQARAFDQIDNAPEEKARGITINTSHVEYETPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVPYILVFLNKCDMVDDAELLELVEMEVRELLSQYDFPGDDTPIIQGSALKALEGDEAYQEKIVELANALDKYIPEPQRDIDKPFLLPIEDVFSISGRGTVVTGRVERGMIKTSDSVEIVGIKDTVTTTCTGIEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGSINPHTKFEAEVYILTKEEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMLVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.