PharMolix/UniProtQA huggingface dataset:
Protein: RS7_CHLL2
Sequence: MSKKGSYKSVGGDFRYGDESVSRFINAVMLDGKKDVAAKIVYDAFDIIAEKMTGENPLEVYRKAMSNIAPVVEVRSKRVGGATYQIPMEVKSSRRGALAFRWLKLYAAKRGGRSMAEKFAAELMDAANEQGASVKKRDEVHRMADANKAFAHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: S2_BPMU
Sequence: MPKSTIIQNLGLQETVNQASGALQQNQNGADIPGKDTFTKNIGACRAYSAWLNIGGDSQVWTTAQFISWLESQGAFNHPYWMCKGSWAYANNKVITDTGCGNICLAGAVVEVIGTRGAMTIRVTTPSTSSGGGITNAQFTYINHGDAYAPGWRRDYNTKNQQPAFALGQTGSTVGNDKAVGWNWNSGVYNANIGGASTLILHFNMNTGSCPAVQFRVNYRNGGIFYRSARDGYGFEADWSEIYTTTRKPSAGDVGAYTQAECNSRFITGIRLGGLSSVQTWNGPGWSDRSGYVVTGSVNGNRDELIDTTQARPIQYCINGTWYNAGSI
What is the function of this protein?
Component of the tail fiber that acts as receptor binding protein.  Binds to the primary receptor, thereby determining the host range.  Two alternate tail fiber S and S' proteins are encoded extending the host range of the virus.
What are the official names of this protein?
Tail fiber protein S', Gene product S', gpS'.
What is the protein family that this protein belongs to?
Belongs to the caudovirales tail fiber protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Tail fiber.
Protein: EFMT2_MOUSE
Sequence: MNADAEGHSGAVVPAQSPEGSSAADDFVPSALGTREHWDAVYERELRTFQEYGDTGEIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELVKHGFSNITGIDYSPSAIKLSASILEKEGLSNINLKVEDFLNPSTKLSGFHVCVDKGTYDAISLNPDNAIEKRKQYVMSLSRVLEVKGFFLITSCNWTKAELLDAFSEGFELFEELPTPKFSFGGRSGNTVAALVFQKRGTSLDKIS
What is the function of this protein?
Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.
What are the official names of this protein?
EEF1A lysine methyltransferase 2, Methyltransferase-like protein 10, Protein-lysine N-methyltransferase Mettl10.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YIDC_RHOBA
Sequence: MADSSVERRLFSFILSSMAFFLIYMSLRTMFAPPLPPEEDAIAEVDGETVEPAEDLVADTDASEPGEGEGEEANEDTDAVERPSSPTWSTLGSMDPTSGYVMLVTLNSRGGGIERIELTERKENGRLKYRRVDVRSGYLGYLAADPTATDLGIRVNVVGPGTPADLATASGVQGGLKPGDIITGFNQNNVNNLSMLREAMLETKPGESATVTVLRNEKSIDFTTTLTEHPLDLIRLAEHGGDDEVEGNLSRLSCLLTVGRVGRREIQSGEKTIEGMVDTGDLIWDASQDGDNVSYQLQLSDSEMKPASGKSVGLQRTYSLKPDSYSLDMDVQIDNRAEEAQELAYRIEGANGITLEGWWYSNKISPNWGGSAARDIVYKTTAEGHELVSGYALLKRAKNESEADDQTLFAPDSAPPARNLSYIGVDAQYFTVAMLPPEGQESLKTFRRAAANIIADPSAVPDNKERAVNASFYLDSAIADVPPGSSLKQSLRLFAGPKQPDVMEAYGLGDCIYYGWFSFVAKPLGGLLHLFSNVGNYALAIVLLTLCVRGLMFPLSRKAAINAQRMQELAPELKKIAEKHKDDMEARVRAQRELQQRVGFNPMAGCAPMFLQLPIFIGLYRTLSVDIELRQAAFASWTTWASNLAAPDMMYYWGDWMWDYLGGRGTGWLGPYFNILPMIVVSLFLAQQKMFMPPATDEQTAMTQKMMNYMTLVMGLFFFRVPAGLCIYFITSSLWGIGERILVKKTLPSKPHFDPATLQGAAAGGGTVDGKVNNSAGANGKKSSDGKPKTMADRLRERLGTPEEEAAPLPKDRKRPPSKKPGNKKRR
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SIAH2_RAT
Sequence: MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11786535).  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11786535).  Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (By similarity).  Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (By similarity).  Promotes monoubiquitination of SNCA (By similarity).  Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11786535).  It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (By similarity).  Has some overlapping function with SIAH1 (By similarity).  Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (By similarity).  Regulates cellular clock function via ubiquitination of circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation.  Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (By similarity).  Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity).  Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase SIAH2, RING-type E3 ubiquitin transferase SIAH2, Seven in absentia homolog 2, Siah-2.
What is the protein family that this protein belongs to?
Belongs to the SINA (Seven in absentia) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Protein: GPDM_RAT
Sequence: MAFQKVVKGTILMGGGALATVLGLSQFAHYRRKQVSLAYVEAATCFSEPVNREPPSREAQLMTLQNTSEFDILVIGGGATGCGCALDAVTRGLKTALVERNDFASGTSSRSTKLIHGGVRYLQKAITNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSHCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGHEFNVRAKCVINATGPFTDSVRKMDDNDVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDSPTDVTHHPIPSEDDINFILNEVRNYLSCDVEVRRGDVLAAWSGIRPLVTDPKSANTQSISRNHVVEVSDSGLITIAGGKWTTYRSMAEDTVNKAVKLHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFDVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPKIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPPDIDRYKKRFHMFDEDEKGFITIVDVQRVLESINVQMDEDTLHEILCEVDLNKNGQVELHEFLQLMSAVHTGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL
What is the function of this protein?
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase, mitochondrial, GPD-M, GPDH-M.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EASA_EPIFI
Sequence: MSTSNLFTPLQFGKCLLQHKLVLSPMTRFRADNEGVPLPYVKTYYCQRASLPGTLLLTEATAISRRARGFPNVPGIWSQEQIAGWKEVVDAVHAKGSYIWLQLWATGRAAEVGVLKANGFDLVSSSAVPVSPGEPTPRALSDDEINSYIGDFVQAAKNAVLEAGFDGVELHGANGFLIDQFLQSPCNQRTDQWGGCIENRSRFGLEITRRVIDAVGKDHVGMKLSTWSTFQGMGTMDDLIPQFEHFIMRLREIGIAYLHLANSRWVEEEDPTIRTHPDIHNETFVRMWGKEKPVLLAGGYGPESAKLVVDETYSDHKNIGVVFGRHYISNPDLPFRLKMGLPLQKYNRETFYIPFSDEGYLDYPYSEEYITENKKQAVLA
What is the function of this protein?
Probable inactive dehydrogenase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid ergovaline, the predominant ergopeptine product in E. festucae var.  lolii (PubMed:17308187).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (By similarity).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (By similarity).  Agroclavine dehydrogenase easG then mediates the conversion of chanoclavine-I aldehyde to agroclavine via a non-enzymatic adduct reaction: the substrate is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione (By similarity).  The presence of easA is not required to complete this reaction (By similarity).  Further conversion of agroclavine to paspalic acid is a two-step process involving oxidation of agroclavine to elymoclavine and of elymoclavine to paspalic acid, the second step being performed by the elymoclavine oxidase cloA (By similarity).  Paspalic acid is then further converted to D-lysergic acid (By similarity).  Ergovaline is assembled from D-lysergic acid and three different amino acids by the D-lysergyl-peptide-synthetase composed of a monomudular (lpsB) and a trimodular (lpsA) nonribosomal peptide synthetase subunit (PubMed:17308187, PubMed:11592979).
What are the official names of this protein?
Probable inactive reductase easA, Ergot alkaloid synthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: HEMH_LEPBJ
Sequence: MKNRILLINLGGPRDTSEIEKFLIDLFEDPLVFDLPLPEWIRKPLGKWVAKKRAPKVAQTYKSMGFGGGSPLVSETSKQANAIAKALEKITGEKWEGNITMTCGYPDIRKLNRDFLVPTKQNILLPLYPHFSRSTVLSTAKLVEQTTKFCPVSYEGWVAPFHSSQVYLESIRDLILDFFQNRLNRKDFLHSDSFQGVSNWETIDLIFSAHGIPIRLIEKGDRYREEINSNVENLKRLLYEKGFQGKCHTSFQSRVGPSKWTEPNTITMLEQLGKNGVKRVAVYPISFVSDHLETLEEIGEQLKKIAYNNGIAEYHRIPAPGIYPKFIEAMAKIGLESIQSSKNECICKKLGGHFPNLKSGECPINF
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_STAEQ
Sequence: MKFAVIGNPISHSLSPLMHHANFQSLNLENTYEAINVPVNQFQDIKKIISEKSIDGFNVTIPHKERIIPYLDDINEQAKSVGAVNTVLVKDGKWIGYNTDGIGYVNGLKQIYEGIEDAYILILGAGGASKGIANELYKIVRPTLTVANRTMSRFNNWSLNINKINLSHAESHLDEFDIIINTTPAGMNGNTDSVISLNRLASHTLVSDIVYNPYKTPILIEAEQRGNPIYNGLDMFVHQGAESFKIWTNLEPDIKAMKNIVIQKLKGEL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).  It can also use NAD to oxidize shikimate.
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: Y2265_MYCTO
Sequence: MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS
What are the official names of this protein?
Uncharacterized protein MT2327.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GUAA_PARPJ
Sequence: MHDKILILDFGSQVTQLIARRVREANVYSEIHPYDVDASFIRDFAPKGVILSGGPSSVTETDTPRVPQAVFELGVPVLGICYGMQAMAEQLGGKVDIGHLREFGYAEVRARNHTSLLEGIKDFTTPEGHGMLKVWMSHGDKVLEMPPGFALMASTESCPIAAMADEKRHFYGLQWHPEVTHTVQGRAMLERFVLQICGARADWEMGNYIDEAVAKIREQVGNEHVILGLSGGVDSSVAAALLHRAIGDQLTCVFVDHGLLRLNEAEQVMATFADHLGVKVIHVDASEVFLRKLAGVTDPEAKRKIIGAEFVEVFQAEAGRLTDAKWLAQGTIYPDVIESAGKGKKGAQTIKSHHNVGGLPETLNLKLLEPLRELFKDEVRELGVKLGLPPAMVYRHPFPGPGLGVRILGEVKRDFADLLRRADAIFIETLRTFIDKETGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTLDFMTAHWAHLPHELLGHVSNRIINEVRGINRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: YFBU_SALPK
Sequence: MEMTNAQRLILSNQYKMMTMLDPTNAERYRRLQTIIERGYGLQMRELDREFGELTEETCRTIIDIMEMYHALHVSWTNLKDTQAIDERRVTFLGFDAATEARYLGYVRFMVNIEGRYTHFDAGTHGFNAQTPMWEKYQRMLNVWHACPRQYHLSANEINQIINA
What are the official names of this protein?
UPF0304 protein YfbU.
What is the protein family that this protein belongs to?
Belongs to the UPF0304 family.
Protein: RL18_FRATM
Sequence: MDKKTARLSRSKRTRIKLRELGHTRLCVYRTPRHVYAQVISGDGSTVLVAASTVEKDVKAKCKYTGNVESAAIVGEIIADRCKEKGISQVAFDRSGYKYHGRVKALVEAAREHGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: YHAM_LISW6
Sequence: MEKRLLDFEVGETVELFLLIKSSIKGTASNGKPFLSLVLQDKSGELEAKLWDVKESDEVNYGVQQIVHLIGDIQNYRGRKQLKIRQIRQATPLDGVNASEFMETAPINKEEMADEITQYIFEMKNANLQRITRALLKKYQDDFYDYPAAMRHHHEFVSGLSFHVVSMLRLAKAVSDLYPTVNRDLLYAGVILHDLGKVIELSGPVSTTYTLEGNLIGHISIVVEEVSKIADELSIDDEEVVVLKHVLLSHHGKGEWGSPKPPLVREAEILHQIDLMDASINMMDKVLKHTKPGEFSERVFGLDNRSFYNPTFE
What is the function of this protein?
Shows a 3'-5' exoribonuclease activity.
What are the official names of this protein?
3'-5' exoribonuclease YhaM.
What is the protein family that this protein belongs to?
Belongs to the YhaM family.
Protein: CCG1_PIG
Sequence: MSQTKALKVRVTLFCILVGIVLALVAVVTDHWAVLSPHVEHLNATCEAAHFGLWRICTKRIAVGDSKDKSCGPITLPGEKNCSYFRHFNPGETSEIFHVTTQKEYSISAAAIAIFSLGFIILGTICGLLSFRKKRDYLLRPASMFYAFAGLCIFVSVEVMRQSVKRMIDSEDTVWIDYYYGWSFACACAAFILLFLGGIALLLFSLPRMPQYPWESCMDAEPEH
What is the function of this protein?
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle.  Regulates channel inactivation kinetics.
What are the official names of this protein?
Voltage-dependent calcium channel gamma-1 subunit, Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Multi-pass membrane protein.
Protein: HIS7_RUEST
Sequence: MRTAQVSRSTAETEISVSVNLDGSGTYDNQTGVGFFDHMLDQLSRHSLIDMTIRAKGDYHIDDHHTVEDTGIALGQALVQALGDKKGINRYGECHLPMDDAQVRAALDLSARPFLVWNVDLPTQKIGSFDTELVREFFQALATHGGITLHIDQIHGVNSHHIAEAAFKAVARALRTAVEVDPRKADAVPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_STAMF
Sequence: MTRPRVKSYFIDYSLKKVMLDEFLANYFKDAGYAGMELYKTPTGYRVVIYAEYPGRIIGRGGSIIRKLMTIMQTHFGLENVNITVSPVPDPDLNARIVAFRIVRALEKEIPYRRVAMAMLRRVMEAGAVGAEIIISGKLRSERARYEKLKAGRIYKAGDMVDYVVDRAVGKALLKRGVYGVEVVIVRPHLKPPDYVEIKSVKPEELADLIPVEKEETNESISPQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: UVSW_BPT4
Sequence: MDIKVHFHDFSHVRIDCEESTFHELRDFFSFEADGYRFNPRFRYGNWDGRIRLLDYNRLLPFGLVGQIKKFCDNFGYKAWIDPQINEKEELSRKDFDEWLSKLEIYSGNKRIEPHWYQKDAVFEGLVNRRRILNLPTSAGKSLIQALLARYYLENYEGKILIIVPTTALTTQMADDFVDYRLFSHAMIKKIGGGASKDDKYKNDAPVVVGTWQTVVKQPKEWFSQFGMMMNDECHLATGKSISSIISGLNNCMFKFGLSGSLRDGKANIMQYVGMFGEIFKPVTTSKLMEDGQVTELKINSIFLRYPDEFTTKLKGKTYQEEIKIITGLSKRNKWIAKLAIKLAQKDENAFVMFKHVSHGKAIFDLIKNEYDKVYYVSGEVDTETRNIMKTLAENGKGIIIVASYGVFSTGISVKNLHHVVLAHGVKSKIIVLQTIGRVLRKHGSKTIATVWDLIDSAGVKPKSANTKKKYVHLNYLLKHGIDRIQRYADEKFNYVMKTVNLISFGPLEKKMLLEFKQFLYEASIDEFMGKIASCQTLEGLEELEAYYKKRVKETELKDTDDISVRDALAGKRAELEDSDDEVEESF
What is the function of this protein?
Plays important roles in recombination-dependent DNA repair and the reorganization of stalled replication forks during viral DNA synthesis.
What are the official names of this protein?
ATP-dependent DNA helicase uvsW, Dar protein.
Protein: CRTC3_XENTR
Sequence: MAATPAASGSNPRKFSEKIALHNQKQAEETRAFDELMSDLTVSRVQFQKLQQLRLAQSRAQYYGGSLPNVNQISSSPTDFQPSFHPTDNIRGMRHHGLVERVSRNRLHSSHHRPIEKHGRQCDSSPYGSVYLSPPPDNNWRRTNSDSALHTSASSTKSQDPFMGGAQAMLRAPKPPQRNTSLQDGEIDNFGEVFSFPNAMTEENMLNVTKPLPKQIWEAQKVQCITSRPRSCEVPNIKVFPSSDSNASLSHFQGSLNTGGSLPDLTNLHFPSPLPTPLDPDDTAYANISAENSSGLPAAMTHLGISGSPGMQNTRSNPSIQATMNNNSLASNVNSHTPPGRNNPALHPSLRLSSLSNPSLPTSALGTSPRRRHTPVSPLTLTPGSESNRSISNQFSPTSPMNMPPNSQGVSMDRSPLSLPPLEPPPPYPLYSDQPQPHLHHTQQQMHESLDSQNYQPPSPVPCPPLDLNLANSSLSGFFGDSFFDQQQPTKQGKYLWQQQEQYDMFGSPSSSLPNTNAFFDPNMNLQYSQASLMGLGGSHGSLQDSFHLRPNYLYSNCGGSVPNIILTDDSSNSLSKDISNAVAGVSELGFDADNTFQLDDELKLGPLSLDGLSMLSDPDMVLPDPSIEDSFRSDKL
What is the function of this protein?
Transcriptional coactivator for creb1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.  Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of creb1 'Ser-119' phosphorylation.  Enhances the interaction of creb1 with taf4.  Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.  Potent coactivator of ppargc1a and inducer of mitochondrial biogenesis in muscle cells (By similarity).
What are the official names of this protein?
CREB-regulated transcription coactivator 3, Transducer of regulated cAMP response element-binding protein 3, TORC-3, Transducer of CREB protein 3.
What is the protein family that this protein belongs to?
Belongs to the TORC family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.
Protein: STMN4_RAT
Sequence: MTLAAYKEKMKELPLVSLFCSCFLSDPLNKSSYKYEADTVDLNWCVISDMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELKEEASR
What is the function of this protein?
Exhibits microtubule-destabilizing activity.
What are the official names of this protein?
Stathmin-4, Stathmin-like protein B3, RB3.
What is the protein family that this protein belongs to?
Belongs to the stathmin family.
What are the subcellular locations of this protein?
Golgi apparatus. Cell projection, growth cone. Cell projection, axon.
Protein: CEF1_KLULA
Sequence: MAPVPIYVKGGIWTNLEDQILKAAVQKYGTHAWSKVASLLQKKNARQCQSRWNEFLNPSLNFKPFSQQEDDKLLDLAKRIPNQWKSIGEMMGRPAQTCIDRYNILLAIDKDDLELAATTGVQIGEINPNNESLPAKADKDELLDEEREMLAEARARLLNTQGKKATRKIRERMLEESKRVAFLQKRRELKQAGVDSKIKAPRKKYSSQMDYNEDIAYEQQPLPGIYDTSKEDEQTEKLLKSFEKLVERKGLLDRKSDEKKTIPQKRRQGEQITSSVTKLDSVLTDEYKKPKLELTPATLKGSKRKINKTTSILHLFESLPSPKNDFEIVLDDLDEEMESTDAFNTESSYVNGKYPLEALISSTEHQSENKAMEIMEYIPTVFQIKTELQVPSPIVDPKNEIDRELNRIISAKENGNPIYNSTEVNNYLEEIINSASTTEVPSTVLHPKLETSLKTITPATEHELLGMERKVHELRTALEDSVKSHREAVSQLSQDFEEKLHPTVSGLAYQYYTDYMKYRNDHKTMQEETQSLAEQIKLAQRSQ
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle control.
What are the official names of this protein?
Pre-mRNA-splicing factor CEF1.
What is the protein family that this protein belongs to?
Belongs to the CEF1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: T2D1_STRPN
Sequence: MELHFNLELVETYKSNSQKARILTEDWVYRQSYCPNCGNNPLNHFENNRPVADFYCNHCSEEFELKSKKGNFSSTINDGAYATMMKRVQADNNPNFFFLTYTKNFEVNNFLVLPKQFVTPKSIIQRKPLAPTARRAGWIGCNIDLSQVPSKGRIFLVQDGQVRDPEKVTKEFKQGLFLRKSSLSSRGWTIEILNCIDKIEGSEFTLEDMYRFESDLKNIFVKNNHIKEKIRQQLQILRDKEIIEFKGRGKYRKL
What is the function of this protein?
An M and P subtype restriction enzyme that recognizes the double-stranded, methylated sequence 5'-G(Me)ATC-3' and cleaves after A-2.
What are the official names of this protein?
Type II methyl-directed restriction enzyme DpnI, R.DpnI, Endonuclease DpnI, Type-2 restriction enzyme DpnI.
What is the protein family that this protein belongs to?
Belongs to the DpnI type II restriction endonuclease family.
Protein: SSRP_LEPIC
Sequence: MVKKKEESGHSPLVNKKAKFNFELISFLEAGIVLSGSEVKSLRDKKGNLTDAFAKIKNGEVFLENFSIAPYKNGGYANHPEIRPRKLLLHKKEIEKLERQVKEKGLVLVATKVYFKNNLRVKVEIAVGKPKKLHDKRDDLQKKDAQQEIARALKSSNRYQ
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: 3NX2_MICSU
Sequence: LTCHTCPYNTCANSETCPAGKNICYQKKWEEHQGERIERRCVANCPKLGSNDKSLLCCRRDDCN
What is the function of this protein?
Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.  Very weak inhibitor of the endogenous nicotinic acetylcholine receptors (nAChR) in the human rhabdomyosarcoma TE 671 cell line.  Not toxic to mice by intraperitoneal injection or to zebrafish by injection at the back of the dorsolateral region.
What are the official names of this protein?
Long neurotoxin MS2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PMBA_ECOLI
Sequence: MALAMKVISQVEAQRKILEEAVSTALELASGKSDGAEVAVSKTTGISVSTRYGEVENVEFNSDGALGITVYHQNRKGSASSTDLSPQAIARTVQAALDIARYTSPDPCAGVADKELLAFDAPDLDLFHPAEVSPDEAIELAARAEQAALQADKRITNTEGGSFNSHYGVKVFGNSHGMLQGYCSTRHSLSSCVIAEENGDMERDYAYTIGRAMSDLQTPEWVGADCARRTLSRLSPRKLSTMKAPVIFANEVATGLFGHLVGAIAGGSVYRKSTFLLDSLGKQILPDWLTIEEHPHLLKGLASTPFDSEGVRTERRDIIKDGILTQWLLTSYSARKLGLKSTGHAGGIHNWRIAGQGLSFEQMLKEMGTGLVVTELMGQGVSAITGDYSRGAAGFWVENGEIQYPVSEITIAGNLKDMWRNIVTVGNDIETRSNIQCGSVLLPEMKIAGQ
What is the function of this protein?
Metalloprotease involved in CcdA degradation.  Suppresses the inhibitory activity of the carbon storage regulator (CsrA).
What are the official names of this protein?
Metalloprotease PmbA, Protein TldE.
What is the protein family that this protein belongs to?
Belongs to the peptidase U62 family.
What are the subcellular locations of this protein?
Cytoplasm.