PharMolix/UniProtQA huggingface dataset:
Protein: AGT2_PONAB
Sequence: MTLIWRHLLRPLCLVTPAPRILEMRPFLNLGASWTSVTKLSLHTKPRMPPCDFMPERYQSLGYNRVLEIHKEHLSPVVTAYFQKPLLLHQGHMEWLFDAEGNRYLDFFSGIVTVSVGHCHPKVNAVAQKQLGRLWHTSTVFFHPPMHEYAEKLAALLPEPLKVIFLVNSGSEANELAMLMARAHSNNIDIISFRGAYHGCSPYTLGLTNIGTYKMELPGGTGCQPTMCPDVFRGPWGGSHCRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAKSIAGFFAEPIQGVNGVVQYPKGFLKEAFELVRARGGVCIADEVQTGFGRLGSHFRGFQTHDVLPDIVTMAKGIGNGFPMAAVVTTPEIAKSLVKRLQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLQFAKLRDEFEIVGDVRGKGLMIGIEMVQDKISRRPLPREEVNQIHEDCKHMGLLVGRGSIFSQTFRIAPSMCITKPEVDFAVEVFRSALTQHMERRAK
What is the function of this protein?
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV).  ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity).
What are the official names of this protein?
Alanine--glyoxylate aminotransferase 2, mitochondrial, AGT 2, (R)-3-amino-2-methylpropionate--pyruvate transaminase, Beta-ALAAT II, Beta-alanine-pyruvate aminotransferase, D-AIBAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KAX2K_CENTE
Sequence: MKAFYGILIILLFCSMFKLNESTTINVKCTSPKQCLKPCKDLYGPHAGAKCMNGKCKCYNNG
What is the function of this protein?
Blocks voltage-gated potassium channels.
What are the official names of this protein?
Toxin Ct28, Potassium channel toxin alpha-KTx 2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 02 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL27_CALS8
Sequence: MKLIFDIQLFAHKKAGGSTRNGRDSESKRLGVKRSDGQFVLAGNILVRQRGTKFHPGKNVGRGGDDTLFALVTGYVKFENKRGRKVVSVIPAEEMVAAQ
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: HPT_PIG
Sequence: MRALGAVVALLLCGQLFAAETGNEATDATDDSCPKPPEIPKGYVEHMVRYHCQTYYKLRTAGDGVYTLDSNKQWTNKVTGEKLPECEAVCGKPKNPVDQVQRIMGGSLDAKGSFPWQAKMISHHNLTSGATLINEQWLLTTAKNLRLGHKNDTKAKDIAPTLRLYVGKKQEVEIEKVIFHPDNSTVDIGLIKLKQKVPVNERVMPICLPSKDYVNVGLVGYVSGWGRNANLNFTEHLKYVMLPVADQEKCVQYYEGSTVPEKKTPKSPVGVQPILNEHTFCAGLSKYQEDTCYGDAGSAFAVHDKDDDTWYAAGILSFDKSCRTAEYGVYVRVTSILDWIQTTIADN
What is the function of this protein?
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine.  Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage.  Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response.  Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
What are the official names of this protein?
Haptoglobin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL16_GEOSE
Sequence: MLMPKRVKYRREHRGRMKGRAKAVRI
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: MMS22_DANRE
Sequence: MESEFSQSLTPPVSPSALNHYGESAPSRPPCFTCAYEAGREDTGRLSSNGYISRGALKRLLLKLDPAPADFGGDTVDIFDFPWVTETALVESTKLLFGLFRQKVLKLETLVQSSSHDFGQASSLHYEAEELRQQCVLFLSYIKVFIYRFLEPSQSLDEGPVHPFKDAEAQLPSVLVEELFSITLLIGRIGNLPANVQSAFTIQHQGKLFPPSWQLLHLHLDIHWSVLEILHLLEQRMMGQVVYAHQFVNLTGETLTNISLFEDQVNNLFCDLIGLAMNKYNKVRPTETLNTHHYHCLCTKELWILLIHLLEHRSKSIHTQSFWSYINALLQTVLKGTTSGDRDPGFPVHCKDPEGFTWWLLTHLAQIGMHNRNGTAQQEKQLEDNWSFVIGLLKSICDPKKAAQEEQIRVVVHCCLSLSLMWGPNVSAVTTFWEYYSKNLNSSFTVPWLGVSGLGSICRTPLCLLQQAKSCCSPAPVGSSSHTQLYRTANSFHIFLRILALHLSQEHAGGAPWRQIKGRLYSKFHQRRMMELSDMGLLHFLLLFLVLAQCAELEDVASRACDLLAMLPTNSTPLALRALQWRGQLALVLLYLEKGLDVGALAEQLAVYFSQAAREFYLKTTEPSRKLALWAPLSSYLEGVSEVFETSPNLTLSEERLLNEGFGLLLPACRQSELSSALGFLQTVLAQLRRVHQRCGQPSHSVDSPSWAPLPSVAKERHQAVAAALWSHFFPFLCSMRLSQTPPPQLADAAAGFTLLALDMPGSAPQNLQPHPIQSIMQSFGWDEMLHPLLVTHYLNHLLQNGELVSWVSSGQGSGSAQALCVRAWIRCVLQQYLHKSPDAPDARAGRNLDEQLAELTRQVFRLPEVEFVLQRAGLQSAAVKDPKAAMAVFLKAVGRSYCELQLLSERSSAVSRALEYVGDILKYIKPYLQNKSREGLQLAYWTIGCLVKHWSHLLATSKAQQLLFRIVDVLLLPHALLQQDTAAHTQMLSALKDSLPMFLQGLSVAVSVSHSQGAYLKQQQHSVISQYLSRFLPATPSTGAVVNHPVLLAACESTPSPQGERLRKSILHVLRENFLQFKGLAPPPRLAAVLCFLLELLKRNSDRDPALLTIPLPSVLRCLMLVNEPQVKRLSSEVTQLIVERCTAAVGEQPCEHTTAILRAFVDENEGVYDQQVYNVLEVVAVLHPFTVAALIPFLTLSLRKTECKRGLGKNTSLRNGYRRLLALLGDSGQAEMISLEED
What is the function of this protein?
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks.  The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication.  It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs.  Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination.  Within the complex, MMS22L acts by binding ssDNA.
What are the official names of this protein?
Protein MMS22-like, Methyl methanesulfonate-sensitivity protein 22-like.
What is the protein family that this protein belongs to?
Belongs to the MMS22 family. MMS22L subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to DNA damage sites, accumulates at stressed replication forks.
Protein: HIS7_ALKEH
Sequence: MMNRSAEVQRDTLETRVKVRLDLDGTGESRIRIGVPFMEHMLDQVARHGLIDLDIEADGDTHIDDHHTVEDVGITLGQALAQALGDKKGIRRYGHAYVPLDEALSRVVVDFSGRPGLQFHVDFVRARIGQFDVDLFQEFFQGLVNHAALTLHVDNLRGINAHHQAETVFKALGRALRMAAEADPRQADRIPSTKGAL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAB_ECOUT
Sequence: MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMTSAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRLQRTRQDKIRLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLSSISDNVFVGTIYINEAKAAMKSGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LCORL_HUMAN
Sequence: MDKGRERMAAAAAAAAAAAAAAQCRSPRCAAERRGFRRELDSWRHRLMHCVGFESILEGLYGPRLRRDLSLFEDCEPEELTDWSMDEKCSFCNLQREAVSDCIPSLDSSQSTPTEELSSQGQSNTDKIECQAENYLNALFRKKDLPQNCDPNIPLVAQELMKKMIRQFAIEYISKSGKTQENRNGSIGPSIVCKSIQMNQAENSLQEEQEGPLDLTVNRMQEQNTQQGDGVLDLSTKKTSIKSEESSICDPSSENSVAGRLHRNREDYVERSAEFADGLLSKALKDIQSGALDINKAGILYGIPQKTLLLHLEALPAGKPASFKNKTRDFHDSYSYKDSKETCAVLQKVALWARAQAERTEKSKLNLLETSEIKFPTASTYLHQLTLQKMVTQFKEKNESLQYETSNPTVQLKIPQLRVSSVSKSQPDGSGLLDVMYQVSKTSSVLEGSALQKLKNILPKQNKIECSGPVTHSSVDSYFLHGDLSPLCLNSKNGTVDGTSENTEDGLDRKDSKQPRKKRGRYRQYDHEIMEEAIAMVMSGKMSVSKAQGIYGVPHSTLEYKVKERSGTLKTPPKKKLRLPDTGLYNMTDSGTGSCKNSSKPV
What is the function of this protein?
May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'.  May play a role in spermatogenesis (By similarity).
What are the official names of this protein?
Ligand-dependent nuclear receptor corepressor-like protein, LCoR-like protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: ESXW_MYCTO
Sequence: MTSRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGWSGMAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS
What are the official names of this protein?
ESAT-6-like protein EsxW.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. CFP-10 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-5 / type VII secretion system (T7SS).
Protein: MCR1_COCIM
Sequence: MFARFTFRTCRPAGQAIRKYASEASPKPSSNVPLYGGLALAAGGAYYYWQRQQSPQALEAALKERSKVFIGGDQGWVDLKLAGIETLSHNVKRFRFEFPDSESVSGLHIASALLTKYKGPKDEKPTIRPYTPVSEEEQPGYLDLVVKQYPNGPMSTHLHNMAVGQQLSFKGPIPKYPWEQNKHDHICMIAGGTGITPMYQIIRKIFNNPNDKTKVTLVFGNITEEDILLKKELDILENTYPRRFRAFYLLDKPPAGWTQGTGYVTKELLKTVLPEPKTENIKIFVCGPPGMYKAVSGPKNSPKDQGELTGLLKELGYDKDQVYKF
What is the function of this protein?
May mediate the reduction of outer membrane cytochrome b5.
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: UBIE_PARPJ
Sequence: MSKTHFGFQSVDEQDKAQKVAGVFHSVAANYDLMNDLMSGGLHRAWKMFTIAQANVRPGYKVLDIAGGTGDLSKAFAKQAGDTGEVWHTDINESMLRVGRDRLLDKGVITPALLCDAEKIPFPDNYFDVVTVAFGLRNMTHKDVALAEMRRVLKPAGRLLVLEFSKVWDPLKKVYDVYSFKVLPWLGERFAKDAESYQYLAESIRMHPDQETLKTMMEQAGLDGVKYYNLSAGVVALHVGTKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RHLB_SHESH
Sequence: MSETHLSNQKFADFSLQTEIKTALNESGFEYCTPIQALSLPILLQKKDIAGQAQTGTGKTLAFLVATFNHLLTTPIPEGRQLNQPRAIIMAPTRELAIQIAKDADLLAKHTGLKVGIVYGGESYEVQRKVLDKGVDILIGTTGRIIDYVRQGIINVSAIQAVVLDEADRMFDLGFIKDIRFLFRRMPDAKSRLNMLFSATLSMKVQELAYDHMNEPEKVEIAPNEKTSKNIKEEIFYPSMDEKMRLLLTLLEEDWPDKAIVFSNTKHSCEKLWSWLEGDGHRVGLLTGDVPQKKRIRILELFTEGKLDVLVATDVAARGLHISDVSHVYNYDLPDDCEDYVHRIGRTGRAGKKGVSVSFACEEYALNLPAIEEYINHTIPVTNYDSEALLDDIPAPVRVHRKHNSRPQGRSGSGGKPRSGNRNAPRRHDKTRRHS
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH42_BURO0
Sequence: MEKALHRISSMNAALPDISLTDAAPGRRPLEWVGMQGIDLPVVVAEPGCRRDVHARADVQVDLPAPQVKGIHMSRLYGLLDGLADGEALSPAGLQRMLRAMVDSHRDCATRSARVRLRFDLLARRTALVTEGLAGWKAYPVRLDATLSGDAFALRAQVTVVYSSTCPCSAALSRHWIEQAFLTAFGHEARVEPTAVAAWLKRHATAATPHSQRSEAVVSVALPADGTTLGLLDLIDRVEQALGTPVQTAVKRADEQAFAVLNGGNLMFVEDAARRVQAALEDRHASPRVRVRHLESLHPHDAVAWAAPLREGADAC
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2 2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: SYFA_METVS
Sequence: MELHNDEKRLLKAFKDSAKNIIDSEGLLEYIEKEKIMRAAFWLTGRDFLNIIEKKSKFLELTELGKNAIESGFPERKVSNYLKTNKLDSFPIKDLSKVLEKDEAGAALGNLKKKELVTIEKGNIFFKSLEYKDLEEELLKKVSLYPNLEEYSKEEILTIETLKKRGFLKLNEVTEREFEITVKGLEYIKNPIEIKEEVTQITRDLIVSGKWKEVSIRPYDAKIPTEEIYPAKAHPMSKIIEEVTEVLTSMGFSEVKSQIVQTEFWNFDTLFEPQDHPARDMQDTFFVKYPDTGIVPHELLKKVKSIHECGKIENEKISKGWCYKFDEEVSKRTVLRTHTTVSSIKYLSSLSNEEKENFHKVFCIDRVFRNETIDYKHLPEFYQCEGIIMAEDVSFNNLVGILKEFLSKLGFEKVRIRPAYFPFTEPSLEAEVYMEGKGWLELLGAGIFRPEVLEPFGIKKPVLAWGIGLSRLAMLRLGLTDIRELHKNDIEWLKKTVVIEK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMKL_ACIBY
Sequence: MNTSLRLNHYWITCADGLETLLQEEIEQLGTKVTERKAGRLIIEGTLEHAYRICMWSRLASRVLLPIHTYELERTHDARDVAEELYEGAISFDWSLIFAPQSTFAIRLHAEREIKVNTQFATLRVKDGVVDSFMEAVGRRPSIDTKQPEITLYVLAGKTEHTYCLDLSGDSLHKRGYRRFMTDAPIKENLAAAILQKAKLQERNPEIVLDPMCGSGTFIIEALMILTDRAPGLVRRFGFNGWHGHDRELWLSLKAEAAERHEKALEQPLPKFYAYDADWEAVKATRENIIAAGFEKLLGDIQIEERTLADWPDFGAENKTAFIVTNPPYGERLGDKASNRSLYLGLSALLQKNFPNQYAAIIAAQIEQADVLAFEAPETLRLMNGKLPIYVRFGTVKPEKVTQPFLANWQAQPVEMEEAQDFANRLQKNMTALKKWATKENIYCLRLYDADLPDFNLAVDLYGDRLHVQEYAPPKKIDPEKAKKRFNLALAAIRAVTGLNRDAIFIKTRARQTGTNQYTKQSTANKRFIVQEGKAKILVNLTDYLDTGLFLDHRQMRLRIAQEARGKHFLNLYSYTSTASLHAALGGAASTTSVDLSNTYLSWSKENFVLNGLTVDHADEQHMFFASDCFEWLKEGHEQYDLIFIDPPTFSNSKKFHGTFDVQRDHVSLIKRAMNRLTSEGTLYFSNNYRGFEMDEEIEALYDVEEITSETIGPDFKRNQKIHRAWKIQHPGLN
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTZE_BACSU
Sequence: MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRDLNVLAYNDLVHSPSRGKWETTRKKVKITS
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YtzE.
Protein: GLGA_ESCF3
Sequence: MQVLHVCSEMFPLLKTGGLADVIGALPAVQIEDGVDARVLLPAFPDIRRGITDAQVVTRRDTFAGPITLLFGHYNGVGIYLIDAPHLYDRPGSPYHDTNLFAYTDNVIRFALLGWVGCEMACGLDPFWRPDVVHAHDWHAGLAPAYLAARGRPAKSVFTVHNLAYQGMFYAHHMDEIQLPWSFFNINGLEFNGQISFLKSGLYYADHITAVSPTYAREITEPQFAYGMEGLLQQRHREGRLSGVLNGVDEKIWSPETDLLLASRYTRDTLEEKAENKRQLQIAMGLKVDDKAPLFAVVSRLTSQKGLDLVLEALPGLLEQGGQLALLGAGDPVLQEGFLAAAAEHPGQVGVQIGYHEAFSHRIMGGADVILVPSRFEPCGLTQLYGLKYGTLPLVRRTGGLADTVSDSSLENLADGIASGFVFEDSNAWSLLRAIRRAFVLWSRPSLWRFVQRQAMSMDFSWHVAAKSYRELYYRLK
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: YG258_YEAST
Sequence: MAFERQGKIEKKISYSLFLNGPNVHFGSILFGAVDKSKYAEELCTHPMRQAYNTLDSNSRIIITVQSVAILDGKLVW
What are the official names of this protein?
Uncharacterized protein YGL258W-A.
Protein: KDM2B_HUMAN
Sequence: MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS
What is the function of this protein?
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645).  Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645).  Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099).  May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).
What are the official names of this protein?
Lysine-specific demethylase 2B, CXXC-type zinc finger protein 2, F-box and leucine-rich repeat protein 10, F-box protein FBL10, F-box/LRR-repeat protein 10, JmjC domain-containing histone demethylation protein 1B, Jumonji domain-containing EMSY-interactor methyltransferase motif protein, Protein JEMMA, Protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B.
What is the protein family that this protein belongs to?
Belongs to the JHDM1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus. Chromosome.
Protein: HBA_TREBE
Sequence: SLSDKDKAAVRALWSKIGKSADAIGNDALSRMIVVYPQTKTYFSHWPDVTPGSPHIKAHGKKVMGGIALAVSKIDDLKTGLMELSEQHAYKLRVDPANFKILNHCILVVISTMFPKEFTPEAHVSLDKFLSGVALALAERYR
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CCR2_MACMU
Sequence: MLSTSRSRFIRNTNGSGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKSLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYLGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQEEDSVYICGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTRQLDQATQVTETLGMTHCCINPIIYAFVGEKFRRYLSMFFRKYITKRFCKQCPVFYRETVDGVTSTNTPSTAEQEVSVGL
What is the function of this protein?
Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (By similarity).  Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity).  Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity).  Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity).  Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity).  Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity).  Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).  Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity).
What are the official names of this protein?
C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2, Monocyte chemoattractant protein 1 receptor, MCP-1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane.
Protein: GLPK_XYLF2
Sequence: MKKKYILAIDQGTTSSRAILFDHKGRIIGMAQREFTQIFPQPGWVEHNPRDIMTSVYTTITELLNNTQIDVRAIAGIGITNQRETTVIWDRQTGQPIYNAIVWQSRQTKDICDQLTTAGYQDMVHAKTGLLIDAYFSGTKVKWILDHVENAHTQAARGELAFGTIDTWIIWNLTGGQVHVTDYSNASRTLLYDIHALRWDPDLLTMLDIPAAILPDVRSSSEIYGLTQTPYFHGEQIPIAGIAGDQQAALFGQACFEPGMAKNTYGTGCFMLMHTGKKAVESQNGLLTTIAWGLNGEIEYALEGSIFIAGSVVQWLRDGLRMFGKASDSQAYADRVSDNGGVYVVPAFVGLGAPYWRSDVRGAVFGLTRSTTKEHFVRAALESMAYQTRDVLSAMQADADIELKELRTDGAAITNDFMAQFQSDILAVPVLRSQIAETTALGAAYLAGLATGFWSSREEMTQHWAINRCFKPQMDKEQREHLYAGWKQAVEATLGFRVA
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: DRS8_PITHY
Sequence: GLWSTIKQKGKEAAIAAAKAAGQAVLNSASEAL
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Dermaseptin-H8, DRS-H8, DShypo 06.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IFT88_MOUSE
Sequence: MENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVNSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANIYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSSGGSRSKREGSAGSDSGQNNSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
What is the function of this protein?
Positively regulates primary cilium biogenesis (PubMed:31761534, PubMed:11062270, PubMed:21289087).  Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
What are the official names of this protein?
Intraflagellar transport protein 88 homolog, Recessive polycystic kidney disease protein Tg737, Tetratricopeptide repeat protein 10, TPR repeat protein 10, TgN(Imorpk)737Rpw.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium, flagellum. Note=Colocalizes with ENTR1 and gamma- tubulin at the basal body of primary cilia. Colocalizes with ENTR1 and pericentrin at the centrosome.