PharMolix/UniProtQA huggingface dataset:
Protein: CPXT_PROM1
Sequence: MKKKPTLEFAKIVSGVFSNKEQALNNPKKFAHIQIHIRPLFFKTYNCFAFYSEQRYQHDIWNPYRQSINKLSQEEEIFIFSNYKIEDKERFTGGALDISLLDKISKYKLYKKPGCSMYFKETNPGNFLGTIESGCKCFIEYGSDKTYVKSKVTVNKNILISEDSGYAIETDKKVWGSEFGPLIFKKIINFDCFINEYWK
What is the function of this protein?
Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.
What are the official names of this protein?
Chromophore lyase CpcT/CpeT.
What is the protein family that this protein belongs to?
Belongs to the CpcT/CpeT biliprotein lyase family.
Protein: RS13_ORITB
Sequence: MSRISNVNVPTNKRVMIGLTYIYGIGRSTAQKICQEVQVSVNKKVKDLSNQELVALRSIIESKYKVEGDLRREINLNIKKKKDIRCYEGLRHIRKLPVRGQNTHSNARTRKGKAIAIAGKKKPNK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: NDHN_SYNJA
Sequence: MLLVGSGAKFVQQLEQCGALAIFVTPEGGSEGHYLRRLRGAGYEVVTLSSKGIGDLASYLTSSHGVRPATLGKSQRRTYFYPSLIEQYRATLPPKAKGLVFWFYEGHVLSRQELSYLVKLSQEDKGVKFVVELGRERSIRWQPLQSA
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit N, NAD(P)H dehydrogenase I subunit N, NDH-1 subunit N, NDH-N.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhN subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GLYA_CHLTB
Sequence: MASLLDRYLRNISDKSQQNLASVAYLASLDHLLHAFPSIGQSIVQELKSQRSRLKMIASENFSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWECAETAKELFGAESAFVQPHSGADANLLAIMSIITQKIQSPAVQQLGYKTINDLPEQEYEALKAEMAQHKCLGPSLNSGGHLTHGTVRMNIMSKLMHCLPYEVNLDTELFDYDEIAKIAKEHKPTVLIAGYSSYSRRFNFATLKQIAEDCGAVLWVDMAHFAGLVAGGVFVGEENPMPYADIVTTTTHKTLRGPRGGLVLAKKEYANTLNKACPLMMGGPLPHVIAAKAIALKEAMTINFRKYAHKVVENAQTLAEVFQRNGLRLLTGGTDNHMLIIDLTSLGVPGRIAEDMLTSVGIAVNRNTIPSDASGQWKTSGIRLGTPALTTLGMGSAEMEEVANIIVKVLRNITVRSNAESGSSKSEGELSEGIAQEARQRVADLLGRFPLYPEIDLETLV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHEU_ECO45
Sequence: MLIPWQDLSPETLENLIESFVLREGTDYGEHERTLEQKVSDVKRQLQCGEAVLVWSELHETVNIMPRSQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: ISPF_PROMH
Sequence: MRIGHGYDVHKFGGEGPIIIGGVRIPYEQGLLAHSDGDVVLHAVTDAILGAVAMGDIGTLFPDTDPAYKGADSRVLLREAFSRVMAKGYRIGNLDVTIIAQAPKMLPHTPQMRVNIAEDLHCHVDDINVKATTTEKLGFVGRKEGIACEAVVLLIKESLS
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: DCA10_MOUSE
Sequence: MFPFGPHSPGGDETAGAEEPPPLGGPAAASRPPSPAPRPASPQRGADAASPPPVAGSPRLPGGPAVSPAERAGEFAAPGALELSAATASASQAKLSPSSSPRRRSRPDWRAGGRSRQGLGAGLGGPGARLFGWLRERSLGRGLFVDPARDNFRTMTNLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRCTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHELDLTKSLEVGSYPILRARRTTSSSDLTTTSSSSGSRVSGSPCHHNDSNSTEKHMSRASQREGVSPRNSLEVLTPEVPGERDRGNCITSLQLHPKGWATLLRCSSNTDDQEWTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF
What is the function of this protein?
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
What are the official names of this protein?
DDB1- and CUL4-associated factor 10, WD repeat-containing protein 32.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DCAF10 family.
Protein: MURC_THEFY
Sequence: MSLVEPTEPVEVDKLGRVHFIGMGGAGMSGIARVLLQRGVEVSGSDARDSALLRELEELGATVHVGHAAEHVGDADTVVVSSAIRDTNPELVEARARNLRILPRAAALGALLLGRCGVAVAGTHGKTTTTSMITVVLQHLGAMPGYVIGGQLVTTGLGADAGADDIIVVEADESDGSFLMLSPRVAVITNVEADHLDNYGDLEEIHDKFAAFIGRVSETVVVGVDDPGARRVAEVARQRGLKVLTYGEADTADYRVRDITVDGFTTMFTIDPPTGDPVHCTLPLPGRHNTLNAAAAVAVADTIGYDPEVAVEGLAEFAGAARRFEFKGEANGVSVYDSYAHHPTEIAADLDAARAALDSQAAKGGKAGRIVVLFQPHLYSRTRIFAEEFAAALTKADEVVVLGIYAAREDPEPGVTAELITERIGHDRVYYRPDRDAAVECVVSVAQPGDIVLTMGAGDVTELGPRIVEALG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_CHLTE
Sequence: MSRIGKMPIRLADQAQVEVKENMINVTGPKGALSQALVDEVIVSVADGAVTVQRKDDSKRARAMHGLYRMLVSNMVEGVTKGFTRKLEMSGVGYRAELKGNLLALTLGYSHMIYFQPPAEIKIEVPDPTTVLVSGIDKALVGQIAAKIRSFRKPEPYRGKGIKYEGEVIRRKEGKAAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: UBC12_XENLA
Sequence: MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDITELNLPKTCEIEFSDHDDLLNFKLVICPDEGFYKGGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK
What is the function of this protein?
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins.  The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4.  Involved in cell proliferation.
What are the official names of this protein?
NEDD8-conjugating enzyme Ubc12, NEDD8 carrier protein, Ubiquitin-conjugating enzyme E2 M.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Protein: G6PI_RUEST
Sequence: MSDIWQQLSAHRAATEATPLTDYFAQDADRFARYSASAGEMLLDYSKTALDDTARDLLVQLAESVDLKSRIAAMMSGAKINSTENRAVLHTALRAPKDAVIEVDGENVVPGIQKVLAQMGAFATALREGSYQTKTGTAFTDVVNIGIGGSDLGPVMATLALAPYHDGPACHFVSNVDGAHIHDVLAGLNPETTLVVIASKTFTTIETMTNAETAIQWLKGALGEDVSTHLAAVSTALDKTAAMGIPDARVFGFADWVGGRYSMWGPIGLPIMIAVGPESFGEFLAGAAAMDQHFRDAPLMENLPALLGLIGVWHNNICGYGSRAVLPYDQRLSRLPAYLQQLDMESNGKSVALDGSPLPRASGPVVWGEPGTNGQHAFYQLLHQGTQVIPTEFLIAATGHEPELAHQHNLLKANCLAQSEALMLGRSWDEAREIAIARGFDGVDADRMAGHLSFPGNRPSVTLAYPKLTPFVFGQIVALYEHRVFTEGVIWGINSFDQWGVELGKELATRLLPMVEGADASQKDASTRGLLAKLST
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYBC_DICDI
Sequence: MTMINPLSYPVPSQYSYTYNNNNNNSNNSSNNNSNNNSNNNNNNNNNCGVPNVSYGSNLNQQSMAQDLRVPEQYSISSPSPKKRPFNSTMTTSPPTPTLLSNSPYIHGSHIVPQYSPQLQNVYNTPHQSSHSIHQPPQQTPNIFNNNNNNNNNNEKSNNQNFGNTLFNSITNNSSNSSNSLIQQNNLTNNGSSSSSSSSSSTNFNQNNNFINSSNDSIYNSNICSFYGNTSSSSSSSLNGIESPPSVELMDDDIEDQLREYISPVIWGMMDNYAREQFYNAIVEFINEEISFRSLLLELRVIAVMDVNYKSIFQFLVDLFLSIEPNQKMVNYLRDNGVEENEFNIDLKSLELSSDNDSNQKKKRERIRKSVSRGLRNPPNKWAKEESQKLIQLVHEHGDKQWKKIAHQIGGGKTGAQCAQHWKRVLCPAIRKGSWDEDEESKLFNLVEKHGQSWKNVASEIRTRTDIQCRYQYFKSCMSREVQWSSREDEILQKKVSENNQQDGTININNTRDISWMDVSKAMARGRQTKIPRTALECKTRYFQLNFGGAPIQIVVPHNDDHLNNPHSPLNSLLQDQNCY
What is the function of this protein?
Transcription activator required for the culmination, at the time of the fruiting body formation.  Regulates genes involved in the cell differentiation within the fruiting body.
What are the official names of this protein?
Myb-like protein C.
What are the subcellular locations of this protein?
Nucleus.
Protein: UL298_HCMVA
Sequence: MSGRRKGCSAATASSSSSSPPSRLPPLPGHARRPRRKRCLVPEVFCTRDLADLCVRRDYEGLRRYLRRFEGSCVSLGWPSQCIYVVGGEHSPHSLTEIDLEHCQNDFFGEFRALHLIGTVSHATCRYQVFVDAYGAVFAYDAQEDCLYELASDLAGFFAKGMIRCDPVHESICARLQPNVPLVHPDHRAELCRRSRASARGRYLRSLLAFRELLACEDTAARCAYVEAHREAQLTLIWPEKHSLVLRTARDLGLSASMLRRFQRSLYTREPVMPLGEIEGAEDKTFFHRVRILCGDTGTVYAALVGQDKLVRLARDLRGFVRVGLALLIDDFRYESIGPVDRSSLYEANPELRLPFKKRRLVVGYFDSLSSLYLRGQPKFSSIWRGLRDAWTHKRPKPRERASGVHLQRYVRATAGRWLPLCWPPLHGIMLGDTQYFGVVRDHKTYRRFSCLRQAGRLYFIGLVSVYECVPDANTAPEIWVSGHGHAFAYLPGEDKVYVLGLSFGEFFENGLFAVYSFFERDYVDEIVEGAWFKHTFAGMYELSQILHDRANLLRVCQLHAGSKIRLGGSPACTFTFGSWNVAEADEANNFVIGVLEQAHFVVIGWMEPVNKAVFMDAHGGIHVLLYGTMLVKLAETLRGFIRQGSFWFRCPRRFCFSPLDSSATVAAKPVSSHTSPAYDVSEYVFSGRSVLDSVSGTGAS
What is the function of this protein?
Contributes to activation of immediate-early gene expression.
What are the official names of this protein?
Protein UL29/UL28.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US22 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host cytoplasm. Note=Expressed exclusively within the host nucleus in early times of infection and then present in both nucleus and cytoplasm at 72 hours post infection.
Protein: EFTS_STRRA
Sequence: MANYTAADVKKLRELTGAGMMDCKKALDEAEGNVEKAVEALRIKGQKGVAKREGRSAENGAVVSIIADDNSSGVLVELKCETDFVAKGEKFQNVATAIAEHVAKAAPADLDALLASEIEAGKTVQAFVDEANANLGEKIVLDRFAQFADGYVLAYMHRTMPDLPPQIGVLVELDKPNAEVAKGVAQHIAAFAPKYLSKEDVRPDVVESERRIAEETTRAEGKPEAAIAKIVEGRVNGFFKDATLLGQPYALDNKKSVQKVLDEAGVTLKRFTRIKVGI
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALM2_SOLTU
Sequence: GCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYDEFVKVMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-2/4, CaM-2/4.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: T3D1A_PIRLC
Sequence: GCLGEGEKCADWSGPSCCDGFYCSCRSMPYCRCRNNS
What is the function of this protein?
Binds at site 4 of sodium channels (Nav) and inhibits the fast inactivation of cockroach channels.  This toxin is active only on insects.  Has a potent activity against S. litura larvae.
What are the official names of this protein?
Delta-amaurobitoxin-Pl1a, Delta-AMATX-Pl1a, Delta-palutoxin IT1, Delta-paluIT1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 07 (Beta/delta-agtx) family. 02 (aga-3) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DGK4_ARATH
Sequence: MESPSIGDSLTARMIPRHSSLDSFGAMKVSLLVNLASIRVSKAELRQRVMLPQYLRIAIRDCILRKDDSFDASSSVAPPLENNALTPEVPLMVFVNPKSGGRQGPLIKERLQNLISEEQVYDLTEVKPNEFIRYGLGCLEAFASRGDECAKEIREKMRIVVAGGDGTVGWVLGCLGELNLQNRLPVPPVSIMPLGTGNDLSRSFGWGGSFPFAWKSAIKRTLHRASVAPISRLDSWNILITMPSGEIVDPPYSLKATQECYIDQNLEIEGEIPPSTNGYEGVFYNYFSIGMDAQVAYGFHHLRNEKPYLANGPIANKIIYSGYGCSQGWFLTHCINDPGLRGLKNIMTLHIKKLDSSEWEKVPVPKSVRAVVALNLHSYGSGRNPWGNLKQDYLEKRGFVEAQADDGLLEIFGLKQGWHASFVMVELISAKHIAQAAAIRLEIRGGDWKDAFMQMDGEPWKQPMTRDYSTFVDIKRVPHQSLVVKGD
What is the function of this protein?
Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule (PubMed:32471859).  PA is required for plant development and responses to abiotic stress and pathogen attack.  May be involved in the accumulation of PA during cold stress (By similarity).  Involved in the regulation of PA and phosphatidylcholine biosynthesis in growing pollen tubes (PubMed:30628082).  Required for nitric oxide-dependent pollen tube growth and re-orientation responses (PubMed:32220864).  Functions together with DGK2 in male gametophyte development and biosynthesis of phosphatidylglycerol and phosphatidylinositol in the endoplasmic reticulum (ER) (PubMed:32471859).  Involved in PA production for pollen grain growth, as well as leaf and root growth (PubMed:32471859).  Possesses guanylyl cyclase activity in vitro (PubMed:30628082, PubMed:32220864).
What are the official names of this protein?
Diacylglycerol kinase 4, AtDGK4, DAG kinase 4, Diglyceride kinase 4, DGK 4.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Cytoplasm, cytosol. Note=Expressed in the cytosol of growing pollen tubes.
Protein: HEM6_FRATW
Sequence: MQEKISKFEDFLTQLQQNITTALEQHETNAAKFISDKWQKPDTPDQKLKGYGNSMIIEGGEIFEKGVVAFSRVHGSELPPSATAKRQELAGKSFIATGLSLVIHPRNPFVPTSHANFRIFIAGADTDNPIWWFGGGFDLTPYYPFEEDAIHWHQTAKNICDKHDKTYYPKFKKWCDEYFYLKHRDECRGVGGLFFDDLNDKSFDECFNFVTDCANSYLDAYIPIVAQRKNIEYSQKHKDFQLYRRGRYVEFNLVFDRGTIFGLQSGGRTESILSSMPPMATWKYNWQPELGSEEEKVYQYIKPRDWIK
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP8_SCIVU
Sequence: MPQLDTSTWFITIISMILALFMLFQSKIANHSYYSNPSHKDMKPTTHSTPWEKKWTKIYLPLSLPLH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: ILVC_LEPIC
Sequence: MANIYYDSDCDLNSLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNAGFEVYSVSEASQKADIIQILAPDTIQADLYKKDIEPNLKKGDALVFSHGFNIHYDFIKPPKEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDSSGEAKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVLCGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNASHPIESVGKKLRSMMKWLSK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: FABR_ECODH
Sequence: MGVRAQQKEKTRRSLVEAAFSQLSAERSFASLSLREVAREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRAFTEAQAEAMVTIVFSAGAEALDVGVEQRRQLEERLVLQLRMISKGAYYWYRREQEKTAIIPGNVKDE
What is the function of this protein?
Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis.  By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.
What are the official names of this protein?
HTH-type transcriptional repressor FabR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NS1_INCCA
Sequence: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDGELLFNGTILQAESTTMTPASVEMKGKKFPIDFVPSNIAPIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGYLIAKQVAGIETGIRKCFRCIKSGFVMATDEISLIILQSIKSGAQLDPYWGNETPDIDKTEAYMLSLREAGP
What is the function of this protein?
Prevents the establishment of the cellular antiviral state initiated by host RIGI, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7.  Participates also in the up-regulation of the splicing of viral mRNAs.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza C viruses NS1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: GUAA_STAA9
Sequence: MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ABCG8_HUMAN
Sequence: MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRFIKQKPSQDW
What is the function of this protein?
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane.  Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092).  Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092).  The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).
What are the official names of this protein?
ATP-binding cassette sub-family G member 8, Sterolin-2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Protein: RL30_METMA
Sequence: MYAVVRLRGQVNVRYTIEDTMKMLRLHKVNHCVFLPENPHYKGMVQKVKDYVAYGKIDAKTLAEVLENRGRLEGDARLTEEYIRENTDYDSIKAFAEAVVEGKASLKDVPKLKPVFRLHPPRKGHAGIKRTVQQGGVLGNHEENINVLLHKMR
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RL10_HAES1
Sequence: MALNLQDKQAIVAEVNEAAKGALSAVIADSRGVTVDKMTELRKAAREAGVSMRVVRNTLLRRAVEGTAFECLTDTFVGPTLIAFSNEHPGAAARLFKDFAKANDKFEIKGAAFEGKIQNVEFLATLPTYEEAIARLMGTMKEAAAGKLARTLAAYRDKLQEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: IPYR_THET8
Sequence: MANLKSLPVGDKAPEVVHMVIEVPRGSGNKYEYDPDLGAIKLDRVLPGAQFYPGDYGFIPSTLAEDGDPLDGLVLSTYPLLPGVVVEVRVVGLLLMEDEKGGDAKVIGVVAEDQRLDHIQDIGDVPEGVKQEIQHFFETYKALEAKKGKWVKVTGWRDRKAALEEVRACIARYKG
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.