PharMolix/UniProtQA huggingface dataset:
Protein: KCY_BARBK
Sequence: MNPFVIAIDGPAASGKGTLARKIAAHYHFHHLDTGLTYRSVAHALLQQGLTCDDETSAIAHAKKLDLNILNPNLLNAHEIGEAASKIATIPAVRKILVAKQRDFIKIPPGSVLDGRDIGTVVCPDADIKFYIVANIQTRAKRRYQEILKRGRHADYQKILADLKQRDERDMTRQQSPLKSAENAHLLDTSELSIEEAFAAACTLIDPLIKARAAL
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3A_STRPY
Sequence: MFAQLDTKTVYSFMDSLIDLNHYFERAKQFGYHTIGIMDKDNLYGAYHFIKGCQKNGLQPVLGLEIEILYQERQVLLNLIAQNTQGYHQLLKISTAKMSGKLHMDYFCQHLEGIAVIIPSKGWSDTLVVPFDYYMGVDQYTDLSHMDSKRQLIPLRTVRYFAQDDMETLHMLHAIRDNLSLAETPVVESDQELADCQQLTAFYQTHCPQALQNLEDLVSGIYYDFDTNLKLPHFNRDKSAKQELQDLTEAGLKEKGLWKEPYQSRLLHELVIISDMGFDDYFLIVWDLLRFGRSKGYYMGMGRGSAAGSLVAYALNITGIDPVQHDLLFERFLNKERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGQAIRDVFKRFGVPEYELTNLTKKIGFKDSLATVYEKSISFRQVINSRTEFQKAFAIAKRIEGNPRQTSIHAAGIVMSDDALTNHIPLKSGDDMMITQYDAHAVEANGLLKMDFLGLRNLTFVQKMQEKVAKDYGCQIDITAIDLEDPQTLALFAKGDTKGIFQFEQNGAINLLKRIKPQRFEEIVATTSLNRPGASDYTTNFIKRREGQEKIDLIDPVIAPILEPTYGIMLYQEQVMQIAQVYAGFTLGKADLLRRAMSKKNLQEMQKMEEDFIASAKHLGRAEETARGLFKRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIMMNYSSSDYITDALESDFQVAQVTINSIPYTDKIEASKIYMGLKNIKGLPRDFAYWIIEQRPFNSVEDFLTRTPEKYQKKVFLEPLIKIGLFDCFEPNRKKILDNLDGLLVFVNELGSLFSDSSFSWVDTKDYSVTEKYSLEQEIVGVGMSKHPLIDIAEKSTQTFTPISQLVKESEAVVLIQIDSIRIIRTKTSGQQMAFLSVNDTKKKLDVTLFPQEYAIYKDQLKEGEFYYLKGRIKERDHRLQMVCQQVQMAISQKYWLLVENHQFDSQISEILGAFPGTTPVVIHYQKNKETIALTKIQVHVTENLKEKLRPFVLKTVFR
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABF2_YEAST
Sequence: MNSYSLLTRSFHESSKPLFNLASTLLKASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPLN
What is the function of this protein?
Specific binding to the autonomously replicating sequence 1 (ARS1).  Interaction with regulatory regions: probably involved in compacting the mitochondrial genome.  It might play a positive role in gene expression and replication.
What are the official names of this protein?
ARS-binding factor 2, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus.
Protein: RALB_HUMAN
Sequence: MAANKSKGQSSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARSKAEEWGVQYVETSAKTRANVDKVFFDLMREIRTKKMSENKDKNGKKSSKNKKSFKERCCLL
What is the function of this protein?
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269).  Accomplishes its multiple functions by interacting with distinct downstream effectors.  Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity).  Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity).  Required for suppression of apoptosis (PubMed:17875936).  In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).  Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179).
What are the official names of this protein?
Ras-related protein Ral-B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=During late cytokinesis, enriched at the midbody.
Protein: TMM54_RAT
Sequence: MCLRIGGLNVDEFRKLLMKTGLVLVVLGHVSFIAAAVLHGTMLRFVATTRDAVVLQYCVVDILSVTSAIVVILAGISAVILSRYLPSTPLRWTVFSLSVACALLSLTCALGLLASIAVTFATKGRALLAPCTFENTELPTLAPDCPFDPTRIYSSSLCLWAISLIFCLAESMSAVRCAQLVHRLLELRPWWGKSCHHTIQASPEPLDGHDLLSCTS
What are the official names of this protein?
Transmembrane protein 54.
What is the protein family that this protein belongs to?
Belongs to the TMEM54 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNMG_CLOBK
Sequence: MKYLAGDFDVVVIGAGHAGCEAALASARMGCKTLICTMNLDSIALMACNPNIGGTAKGHLVREIDALGGEMGINIDHTFIQSRMLNTSKGPAVHSLRAQADKKRYSERMKHLLEKEENVVLRQLEVIEIDVEDNEVKGVLTKNGAYFTTKAIILCTGTYLKGKIIIGDIIYSSGPSGLYPANDLSQSLLNLGINLRRFKTGTPARINKRSVDFSKMIEQPGDEKIVPFSFIHNKLDKDQISCYLTYTSEETHKIIHENIHRSPLYNGSIEGVGPRYCPSIEDKIVRFPDKDKHQIFIEPEGENTEELYVGGMSSSLPEDVQIKMYRSVPGLENAEILRTAYAIEYDCIDPQQLDLTLEFKNINGLYGAGQFNGSSGYEEAAAQGLIAGINAVLKIKEKNPLILKRSDAYIGVLIDDLVTKGTNEPYRMMTSRAEYRLLLRQDNADLRLTELGYKVGLVKEDRYNKFLNRKKNVENEIERLRNMQITGKREINEFLLEKGSTELKKPISLYELIKRPELDYFKVEPLDDKRPSLSDDEKEEINIIAKYEGYINKQLEQVEQFKKYEDRLIPKSINYLDIKGLRLEAIQKLEKIKPINIGQASRISGVSPADISVLLIYMERKDREN
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYW3_PIG
Sequence: MDRRAEFKRWKAQCLSKADFSRKGCVDEDVVEIVQLLNGREQFFTTSSCAGRIILLEQGMDSLEVQKQNCCWLLVSHKPCVKDDVIVALKKANGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLKIANHKMEENKKRIERFYNCLQLALEKETTTTNSHPKEKIKEKNNSYKKKSNPGKAHDKCVTEENDKVLENDDDDDPGISVTIFPEDY
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 3 homolog, tRNA-yW-synthesizing protein 3, tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TYW3 family.
Protein: FLOA_EXIS2
Sequence: MTPELLTVLLITGGILIFLAIFFTLVPIPLWISSLAAGVRVSIFTLVGMRLRRVTPSKIVNPLIKAVKAGINLNTNQLESHYLAGGNVDRVVNALIAAHRANIELSFERAAAIDLAGRNVLEAVQMSVNPKVIETPFIAGVAMNGIEVKAKARITVRANIDRLVGGAGEETVIARVGEGVISTIGSCQDQKEVLENPEMISRTVLAKGLDSGTAFEILSIDIADVDIGKNIGAVLQTDQAEADKNIAQAKAEERRAMAIASEQEMKSRVEEMRAKVVAAEAEVPLAIAEALRDGNFSVMDYANYLNVTADTKMRQAIGGQSSPNDTQ
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: LGT_BACC4
Sequence: MLLASVPQLDRVAIQLGPFPVYWYGIIIGTGVLLGLWLATREGERLGIPKDTFVDLVLIAVPIAILFARMYYVIFEWEYYAQNPSQIINIRQGGLAIHGGLIGAVITGVLFAKRRGVSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGDEVTRQFLEGLHLPDFIINQMYIEGVYYHPTFLYESLWNFAGVILLLALRKVNLRRGELFFTYLIWYSVGRFFVEGLRTDSLMLGPLRIAQVMSIGLVVISIIFIIVRRKMGQADKRYLEN
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAIA_ECOL6
Sequence: MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEHGGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMWNSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVYTEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHERFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEAAWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVSGGSDEMQILTLGRAVLKQYR
What is the function of this protein?
Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
What are the official names of this protein?
Crotonobetainyl-CoA reductase, Crotonobetainyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN2H_SYNY3
Sequence: MEKGQLIEFRHQGERRLAVVDRPDGKKDWVVIDQQGQSHKLKPQRVEYEIPGGPYTVDDLPSFLGEVDQYLDPSSLEVAWELLIEEGESITPADLALLLFSEQSPSQCYAAHALLAEDKLYFKQKGNHYEPRPSSQIEEIKHQMRVQAQKEQEQQGFIDRVNQALAGEKVTWEGSDRLRLEALEKFILFPEQNHRQALDILQTLGKPGRTDETQNLLIELGIWQRHENLFLRRSAYPNQFPAKVSDVAHAYLTNPPPDPDQERFDLTTLKTYTIDDESTSEIDDGLSVETLADGGHRLWIHVADPTRLLSPNDELDLEARKRSTSLYLPTGMISMFPPELATGPMSLLQGQRCVALSFGVTLDEVGAVRDFTIAPSWVKPTYRLTYEDVDEMLVLKIQGEPELPLLAEAAKKRAQWRKSQGAITIKMPEAIIKVNADEEVQIYLQETSVSRQLVAEMMILAGEVAGRFCQEHGIPVPFRGQPQPELPSDEELLSLPPGPVRECAVRRCMPRSEVGITPSRHASLGLDLYSQATSPIRRYTDLITHFQMKAYLRGEPLPFSGEQVQEILYSVMPSSKEATLVERQTNRYWSLEFLRRNINEVWQGVMLRWLREDDGLGLILLEELGLELPHRFDRPISPGDRLSLKVSNADPHRDEIRFRELLANEA
What are the official names of this protein?
Uncharacterized ribonuclease sll1290.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family.
Protein: YVBH_BACSU
Sequence: MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFLIKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIKFKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHTRPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN
What are the official names of this protein?
Uncharacterized protein YvbH.
Protein: CC181_RAT
Sequence: MDEDKGIDSKESGEYEDDFEKDLEWLINDKEKSNGSMIEVACKKEDDLDQELKEKETETELGPQLSDPDKPPKDEALPRRNDFISVPSIQPLDPISDSDSENSFQDSKPENQKDLEDEEDEEVRRYIMEKIIEANKLLQTQEPVNDKRERKLKFKDKLVDLEVPPLEDSDTCKVLLENETNMSGKLSQLCISGDLGQESMLMSVTNGGCEENDRKILVERDGKFELMNLQDIESQGFLPPISSANGMEHESSQLPLRSANLSVGGIKKEEPEAKIHIMTLSQAGEPLAQVPQPPANPKNRPSSAANPDLNKKTRRSSHRIQSAGVSPVTSTYCLSPRQKELQKQLERKRERLKREEEQRKLEEENEKKKENEMVFKAWLQKKREQVVEMRRVQRAKQIEDMSSRQVNRDPQQAFRLWLKKKHEEQMKERKTEELRKQEECLFFLRGTEGRERAFRQWLRRKQIEKIAEQQAVKERARQLRLEARRSKQLQSGLYSVPEAKAFRFTDHYN
What is the function of this protein?
Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
What are the official names of this protein?
Coiled-coil domain-containing protein 181.
What is the protein family that this protein belongs to?
Belongs to the CCDC181 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localizes to the microtubular manchette of elongating spermatids. Localizes to the sperm flagella and to the basal half of motile cilia.
Protein: ECFA_CARHZ
Sequence: MNLAVEIENLTFFYPDGNKALDGVSFVIPERSKTVILGHNGAGKSTLLLHLNGLYTASRGRVKIFGKVINEENIREIRKKVGLVFQDPDDQLFASTIFDDVAFGPQNLELDKKEILRRVEEALKAVDMWDLRERPPHHLSLGQKKRAAIAGVLAMEPDIVVLDEPMAYLDPRGQEEITAILNRLNNEGKTVIVSTHDLDWALEWADYVVVLNAGRVVAEGDKSILTNRQLLEQNGLKAPLLVKLFEDFEGKLGIPTNLKEARQILRKFIF
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA, ECF transporter A component EcfA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RPN2_DICDI
Sequence: MKLIILIVLSILISIVISGSVQSKITTTRGISNVYSKNDINNIKQFISSKYNGNTKLYGESLKDTFYGVGVLTRIGETNIEATKDICKQTKEQLKQNKFTDIELVFNGVTILSELKCLQGESSSSLGNEQQLQDLLKNKLENGSLLEKTQAINIYFTLSSAKAIDSKTVSIIDPLLIQAVNSMVSLMDEDGTFKSVSTDDEGNLQNTAAAYFALARLSHRLKSNEVDKLVAKVVNKVDTVLASADETTDSLYFNDLSTTSSLLHGLLSLASVNDKVADVISNKQINQISEYLLRQKNVESLSDAYHLIVALKRCQKNSISQPISLALVKSIYSPSGLNDIRVRVTDIFDQPIEASIVINKVVSSKNPRSTPILSGKEMKFQSSDNSFVADLSNENLKLGSYNFEFKVQPVDTDSYKSITNIQIITITGAVTVNDMKLSYAPKSDQLGSPKTTNEVQFGQKLPLIEIPSNNIARIFFRIASEAQPYQAQQVGIRFYSPAREAVVPATYSADAYSYTFTNKDACKILGCQSGNYQLDLIIGDQSITPLQWNFGEINLKFNQSTIPTNRYPEQLPISHNFRVAEKRPPQSISSLFTLLVLSPIAIFVIGLLFVGTNLGRFPTGMGFIYTIGFLGCISATGLLIVNYWLHSTMDVTLKNLALLMIPLVFFGHKSMSYYSNLSSSNIKKD
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit swp1, Oligosaccharyl transferase subunit swp1, Ribophorin II, RPN-II, Ribophorin-2.
What is the protein family that this protein belongs to?
Belongs to the SWP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS3_METTH
Sequence: MIEKDFVVEGLRRTRIDEYLEKELERAGYGGMDVQVTPMGTMVVVYAERPGMVIGRGGKTVRAITQKLKNKFDLENPQVEVKEVDVPELNPKIMAHKIAAMLQRGMHFRRVAYTTMRRIMAAGAQGVEVTISGKIRGARSATAKFTDGYIKKCGEPSVKHVREGFATVQLKPGVLGVYVRIMPPDVVLPDKVEIEDPRVTETPAEEASEASEVVEDLEEVEDLEEIEDLEEVEDLEEVEDLEDTEAEKKDADGEESEK
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RL3_COXBN
Sequence: MSIGLIGRKCGMTRIFTETGSSIPVTVVEVIPNRITQVKTVETDGYRAFQVAYGKKSSARVNKPLAGHYSKAAVEAGNALREFRLGNEELTEAKAGDELKVDIFKEGQVVDVRGLTRGKGFAGTVKHHNFRTQDATHGNSLSHRAPGSIGQCQTPGRVWKGKKMAGQLGNVYCTVQSQEIIKVDVERNLLLIKGALPGAPGGEVIITQSSKKRKEDK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PMA2_ARATH
Sequence: MSSLEDIKNETVDLEKIPIEEVFQQLKCSREGLTTQEGEDRIQIFGPNKLEEKKESKLLKFLGFMWNPLSWVMEMAAIMAIALANGDGRPPDWQDFVGIICLLVINSTISFIEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEAAILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPVTKHPGQEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGHFQKVLTAIGNFCICSIAIGMVIEIIVMYPIQRRKYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLVEVFCKGVEKDQVLLFAAMASRVENQDAIDAAMVGMLADPKEARAGIREVHFLPFNPVDKRTALTYIDGSGNWHRVSKGAPEQILELAKASNDLSKKVLSIIDKYAERGLRSLAVARQVVPEKTKESPGAPWEFVGLLPLFDPPRHDSAETIRRALNLGVNVKMITGDQLAIGKETGRRLGMGTNMYPSSALLGTHKDANLASIPVEELIEKADGFAGVFPEHKYEIVKKLQERKHIVGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALIWEFDFSAFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVLGGYQAIMTVIFFWAAHKTDFFSDTFGVRSIRDNNHELMGAVYLQVSIISQALIFVTRSRSWSFVERPGALLMIAFLIAQLIATLIAVYANWEFAKIRGIGWGWAGVIWLYSIVTYFPLDVFKFAIRYILSGKAWLNLFENKTAFTMKKDYGKEEREAQWALAQRTLHGLQPKEAVNIFPEKGSYRELSEIAEQAKRRAEIARLRELHTLKGHVESVVKLKGLDIETPSHYTV
What is the function of this protein?
The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport (PubMed:10748244, PubMed:12920605, PubMed:27013734).  The resulting external acidification and/or internal alkinization may mediate growth responses (PubMed:10748244, PubMed:12920605).  Involved in maintaining the membrane potential and delta-pH, together forming the plasma membrane protonmotive force (PMF) required for root and hypocotyl elongation and root tropism (PubMed:22214817, PubMed:24492258).  Important for root growth and development during different nitrogen regimes (PubMed:25382626).  Forms a functional cation-translocating unit with CNGC17 that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes (PubMed:26071421).
What are the official names of this protein?
ATPase 2, plasma membrane-type, Proton pump 2.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NDF1_HUMAN
Sequence: MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDDLETMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGAQSHGSIFSGTAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD
What is the function of this protein?
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'.  Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A.  Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine.  Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification.  Also required for dendrite morphogenesis and maintenance in the cerebellar cortex.  Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
What are the official names of this protein?
Neurogenic differentiation factor 1, NeuroD, NeuroD1, Class A basic helix-loop-helix protein 3, bHLHa3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus.
Protein: BIOW_AQUAE
Sequence: MDLFSVRMRAQKNGKHVSGAERIVKKEELETAVKELLNRPKEFDFMNVKVEKVKDFEVVKFNLKISTYSFKSPEEAREFAVKKLTQEGIKEEVAKKAVEILSKGANPKGGNMRGAVLMDIETGERLEEDKERGVRTIHFDWKDRKKVTEKLLKEGYTLRTVDALALTFKNLFCGVVAELCWSDDPDYVTGYVSGKEIGYVRITPLKEKGDPLGGRVYFVSRKELSEIIECLTQKVVLIEL
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: TIKI2_HUMAN
Sequence: MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTRVYFELDLTDPYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTERDVRFRGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQVLFALNQTLLQQESVRAGSLQASYTTEDLIKHYNCGDLSAVIFNHDTSQLPNFINTTLPPHEQVTAQEIDSYFRQELIYKRNERMGKRVMALLRENEDKICFFAFGAGHFLGNNTVIDILRQAGLEVDHTPAGQAIHSPAPQSPAPSPEGTSTSPAPVTPAAAVPEAPSVTPTAPPEDEDPALSPHLLLPDSLSQLEEFGRQRKWHKRQSTHQRPRQFNDLWVRIEDSTTASPPPLPLQPTHSSGTAKPPFQLSDQLQQQDPPGPASSSAPTLGLLPAIATTIAVCFLLHSLGPS
What is the function of this protein?
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins.  Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.  Able to cleave WNT3A, WNT5, but not WNT11.  Required for head formation.
What are the official names of this protein?
Metalloprotease TIKI2, Heart, kidney and adipose-enriched transmembrane protein homolog, TRAB domain-containing protein 2B.
What is the protein family that this protein belongs to?
Belongs to the TIKI family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GLPB_PECCP
Sequence: MRYDVVIIGGGLAGLTCGIRLAEQGKRCAIVSAGQNALHFSSGALDLLSHLPDGQPVSQPLEALDELARQAPHHPYSRMGAAAVAALLPQVEALLERSTISLLGSYQQNHWRMTPLGKFRACWLSPVDGVTRGLPDSRFGDNPLIAGIEGFLDFQSRIVAGTLQAQGIAARSDDLKLPVLDRLRQNPSEFRAVNIARVLDRPENRAALVEELSLLANGNDAIIMPACLGLDSPEVVGELAEALGKPISLLPTLPPSVLGLRLHQALSQRFRQLGGMVMPGDRAVRASLSAQEIAVHSHHHRDIPLRAKYAVLASGSFFSNGLVTQFDRVTEPVFGLDVRFAEQREGWSQQDVFVPQPYMQFGAIVDEHLHPRIGGETIGNLYAIGAVLEGFDPIAQGCGAGVSLLSALHVAEQILKEGNL
What is the function of this protein?
Conversion of glycerol 3-phosphate to dihydroxyacetone.  Uses fumarate or nitrate as electron acceptor.
What are the official names of this protein?
Anaerobic glycerol-3-phosphate dehydrogenase subunit B, Anaerobic G-3-P dehydrogenase subunit B, Anaerobic G3Pdhase B.
What is the protein family that this protein belongs to?
Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
Protein: GREA_MYCS2
Sequence: MTDTQVTWLTQEAFDRLKAELDQLIANRPVIAAEINDRREEGDLRENGGYHAAREEQGQQEARIRQLQELLNNAKVGEAPKQSGVALPGSVVKVYYDDDENDTETFLIATRQEGISDGKLEVYSPNSPLGGALLDAKVGESRTYTVPSGNVVKVTLVSAEPYQG
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: PP2B5_ARATH
Sequence: MGQKHGVDTRGKGAEFCGCWEILTEFINGSSASFDDLPDDCLAIISSFTSTPRDAFLAALVSKSFGLQFNSDSVWEKFLPPPDYVSLLPKSRVFSSKKELYFALCDPFPNHNGKMSFRLDKASGKKCVMLSAKKLLISRVVNPKYWKWISIPESRFDEVPELLNIDSFDIRGVLNTRIISPGTHYSAYIVYTKTSHFNGFQTSPIQAGVGFQRHGMSKTFIRFDSKKRQDGWMEAKIGDFYNEGGLIGFNLIEVSVVDVARYPHMNMKSGLIIEGIEFRPKDSR
What are the official names of this protein?
F-box protein PP2-B5, Protein PHLOEM PROTEIN 2-LIKE B5, AtPP2-B5.