PharMolix/UniProtQA huggingface dataset:
Protein: AVR2B_PIG
Sequence: MTAPWAALALLWGSLCVGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRNAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPAIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
What is the function of this protein?
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c).  Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.  Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.  Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA).  The type-1 receptors like ACVR1B act as downstream transducers of activin signals.  Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase.  The activated receptor type-2 then phosphorylates and activates the type-1 receptor.  Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail.  Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4.  This SMAD complex translocates into the nucleus where it mediates activin-induced transcription.  Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.  Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity).
What are the official names of this protein?
Activin receptor type-2B, Activin receptor type IIB, ACTR-IIB.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: COBS_KLEP7
Sequence: MIKSFFAALSFISRLPVPARLSQGLEIEQYQRSIVTFPLVGLLLGAIAGAVALLLQPWCGVPLAALFGVLALALLTGGFHLDGLADTCDGIFSARTRDRMLEIMRDSRLGTHGGLALIFVLVAKVLVVGELLLRDIHPIAALAAACAVGRGMAALLMYRHRYAREKGLGNLFIGKISLQQTLVTMAMAIALATALLGLQGLRAALITLVLIWGLGWALKRTLGGQTGDTLGAAIELGELLFLLALL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MYSP_ONCVO
Sequence: MSGSLYRSPSAALYKSPSMSAFSGLPAAFGSMSVADLGSLTRLEDKIRLLQEDLESERELRNRIERERADLSVQLIALTDRLEDAEGTTDSQIESNRKREAELQKLRKLLEESQLENEDAMNVLRKKHQDACLDYTEQIEQLQKKNSKIDRERQRLQHEVIELTAAIDQLQKDKHLAEKAAERFEAQTIELSNKVEDLNRHVNDLAQQRQRLQAENNDLLKEIHDQKVQLDNLQHVKYQLAQQLEEARRRLEDAERERSQLQAQLHQVQLELDSVRTALDEESAARAEAEHKLALANTEITQWKSKFDAEVALHHEEVEDLRKKMLQKQAEYEEQIEIMLQKISQLEKAKSRLQSEVEVLIVDLEKAQNTIAILERAKEQLEKTVNELKVRIDELTVELEAAQREARAALAELQKMKNLYEKAVEQKEALARENKKLQDDLHEAKEALADANRKLHELDLENARLAGEIRELQTALKESEAARRDAENRAQRALAELQQLRIEMERRLQEKEEEMEALRKNMQFEIDRLTAALADAEARMKAEIARLKKKYQAEIAELEMTVDNLNRANIEAQKTIKKQSEQLKVLQASLEDTQRQLQQTLDQYALAQRKVSALSAELEECKVALDNAIRARKQAEIDLEEANGRITDLVSINNNLTAIKNKLETELSTAQADLDEATKELHAADERANRALADAARAVEQLHEEQEHSMKIDALRKSLEEQVKQLQVQIQEAEAAALLGGKRVIAKLETRIRDLETALDEETRRHKETQGALRKKDRRIKEVQMQVDEEHKMFVMAQDTADRLLEKLNIQKRQLGEAESLTMANLQRVRRYQRELEDAEGRADQAESSLHLIRAKHRSSVTAGKNASASKIYVLEDDQ
What is the function of this protein?
Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
What are the official names of this protein?
Paramyosin.
What is the protein family that this protein belongs to?
Belongs to the paramyosin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Protein: FZD7_XENTR
Sequence: MFATVSLLFCLLLQPSPSAQQYHGEKGISVPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDNSPSGPTARPTPYLPDSITFHPHPNRDFTCPRQLKVPPYLGYRFLGEKDCGAPCEPGKANGLMYFKEEEVRFARLWVGIWAILCGISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYTAGFLLEERGVCVERFSEDSYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVMYTVPATIVLACYFYEQAFRDTWEKTWLVQTCKGFAVPCPNYNFAPMSPDFTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRFYHRLSNGGKGETAV
What is the function of this protein?
Receptor for Wnt proteins.  Acts in both canonical and non-canonical Wnt pathways.  Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists.  In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal axis of the embryo and induce dorsal mesoderm formation.  In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension movements in gastrulation.  Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane.  In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC.  PKC signaling controls cell sorting and tissue separation during gastrulation (By similarity).
What are the official names of this protein?
Frizzled-7, Frz7, Fz-7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions.
Protein: DDL_STACT
Sequence: MAKENICIIYGGKSAEHDVSILTAQNVLNAINKDDYQVDIIYITNDGAWKKKDDITENVEDVDSLRLEEVEEGEISNLLTNSSSGQPYAAVFPLLHGPNGEDGTIQGLFEVLDLPYVGNGVLAASSTMDKLVMKQLFAHRGLPQLPYVSFLRSEYEKYQSNILKLVKDKLEFPVFVKPANLGSSVGISKCNNEEELKSGIEEAFQFDRKLVIEQGIEAREIEVAVLGNDYPETTQPGEVVKDVAFYDYKSKYLDGKVQLSIPAELDSEVQTTLRNMAAEAFKATDCSGLLRADFFVTEDNQIFINETNAMPGFTQYSMYPSLWENMGLSYADLITKLIELAKEKHVEKQKNKYKID
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAJL_NOSS1
Sequence: MNKSQDKEKKYFLEYLSLAPVLAVISISVAFSTWAIFNYIFPDLLFHPLP
What are the official names of this protein?
PsaJ-like protein asl3190.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: LONB_PYRAB
Sequence: MLKFYKMGIKRLSGEMTMGEERMDLGIEFETTEEIPVPERLIDQVIGQDHAVEVIKTAAKQRRHVLLIGEPGTGKSMLGQAMAELLPTEDLEDILVFPNPEDENMPRIKTVPAGQGRRIVEEYKRKAKEQENIRFYLLFFVFFIVAMAVFMSRGDPNTLLLGVFVILIALMVTANMRFRTQAMVPKLLVDNSGRKRAPFVDATGAHAGALLGDVRHDPFQCFSGEETVVIRENGEVKVLRLKDFVEKALEKPSGEGLDGDVKVVYHDFRNENVEVLTKDGFTKLLYANKRIGKQKLRRVVNLEKDYWFALTPDHKVYTTDGLKEAGEITEKDELISVPITVFDCEDEDLKKIGLLPLTSDDERLRKIATLMGILFNGGSIDEGLGVLTLKSERSVIEKFVITLKELFGKFEYEIIKEENTILKTRDPRIIKFLVGLGAPIEGKDLKMPWWVKLKPSLFLAFLEGFRAHIVEQLVDDPNKNLPFFQELSWYLGLFGIKADIKVEEVGDKHKIIFDAGRLDVDKQFIETWEDVEVTYNLTTEKGNLLANGLFVKNSGGLGTPAHLRVEPGMIHRAHKGVLFIDEIATLSLKMQQSLLTAMQEKKFPITGQSELSSGAMVRTEPVPCDFILVAAGNLDTIEKMHPALRSRIRGYGYEVYMRTTMPDTVENRRKLVQFVAQEVKKDGRIPHFTRDAVEEIIREAQRRAGRKGHLTLRLRDLGGVVRAAGDIAVRKGKKYVTREDVLEALQMAKPLEKQLADWYIERKKEYQVIRTEGGEIGRVNGLAIIGEQSGIVLPIEAIVAPAASKEEGKIIVTGKLGEIAREAVLNVSAIIKRYKGEDISRYDIHVQFLQTYEGVEGDSASISVATAVISALEEIPVRQDVAMTGSLSVRGEVLPVGGVTPKIEAAIEAGIKKVIIPKANEKDVFLSPDKREKIEIIPVERIDEVLEVALVESEKKKELIKRIRETLPLGVSESAGSETLHEHGRDSGSALSVEESKA
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Degrades polypeptides processively (By similarity).
What are the official names of this protein?
Archaeal Lon protease, ATP-dependent protease La homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family. Archaeal LonB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THNS1_MOUSE
Sequence: MLTLTRCHHLKQIAQECLSSLLVKVQSRTQLLLPRASARAESGKSWHSTHSLVGDKNIVLMGPPGSGKTTVGRILGDKLGCCVIDVDSDVLEKAWNMSASEKLQDVGNERFLEEEGKTVLNLSASGSVISLSGSNPMHDASMWHLKKNGIVVYLDVPLTDIISRLKSMRIDRIVGQNTGASLRDSLKHVRLYYKKWYDARVFCESGASAEEVADKVLDVVKRYQDVDSETFISTRHVCLKDHDKKFPPKYFSEAVVEGLASDGGLFVPEKEFPKLSPGEWNNLIGATYIERAQVLLERCIHPADIPAAKLGEMIETAYGENFACSKVAPVRHLSGNQFILELFYGPTGSFKDLSLQLMPHIFAYCIPPGCNYVILVATSGDTGSAVLNGFSHLNKNDKERIAVVTFFPENGVSDFQKAEIIGSQRENGWAIGVRSDFDFCQTAIRKIFNDSDFTGFLAVEYGTILSSANSINWARLLPQIVYHASAYLELVNQRFISFGSPVDVCVPTGNFGNVLAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRNRKLAQTFSPSIDILKSSNLERHLYLMANKDGQLMANLYHQLESQLHFRIEKMLVEKLQQEFVADWCSEGECLAAISTTYNASGYILDPHTAVAKVVADKMQDKSCPVLIASTAHYSKFAPAIMQALGIKELNQTSSSQLYLLSSYNALPPPHEALLERMKQKEKMDYQVCVADVDVLKSHAEKLIQNWFVRKSE
What are the official names of this protein?
Threonine synthase-like 1, TSH1.
What is the protein family that this protein belongs to?
Belongs to the threonine synthase family.
Protein: PUR7_WOLPM
Sequence: MSLNKTIYEGKAKAIIETEDLSIVIQHFKDDVTAFNKEKYEIIDGKGIINNHISAFIMEKLEKAEISTHFIKTLNEREQLVKKLKIIPLEVVVRNVAAGSFCKRFNIKEGERLASPIIDFFYKNDDLADPMVSENHILYFDWLSSKEMDEVKTTTLKINEILVHLFSNASIYLVDLKLEFGRLINDSTKIVLADEISPDNCRLWDKNTYKKLDKDVFRLNLGDLKEAYLEVAKRLSVKLG
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RLME_BDEBA
Sequence: MTYNPRDHYFRKAKQENFAARSVFKLEEIDQKFKMFKPGQVVLDLGASPGSWSQYASKMAGEKGRVLGVDLSPVTVKLKNAVFIQADLRDLNLEDIFKEHGFVPPFDIVMSDMAPKTTGIRMTDQARSMELCELALDVARRFLKKDGHFVCKLFHSDDFGKLRDEMKKTFAKVEAVKPDSTRKISKEIFLVGLSKK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPA4_DICDI
Sequence: MRFKCFGSEETEQSSKIDKSIETDRRKLRKDVKLLLLGPGESGKSTIFKQMKIIQEDGGYSVEELLEYRAFVYSNCISQMEALLTASAKLNIELEVENKQRAANVLRRTIGNEPWLLLAADIKHLWEDKGIKETYAQKDKHFQLNDSAAYFFDNIDRYMREDFVPNEQDVLRCRVRTTGIQESEFTFDKIRLKIVDVGGQRSQRRKWIHCFDCVTAVIFVAAMSDYDQVLREDESVNRTRESLALFKEIVNCDYFKETPIVLFLNKKDLFKEKLKRVPLQSCFSDYTGPNKYKDAAMFIQSQYLAQGPSPRTIYTHATCAVDTENIKFVFRAVRQTILSQALEHF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  G alpha-4 plays a role in morphogenesis of the multicellular structure.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-4 subunit, G alpha-4.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: MDHNP_ARATH
Sequence: MAMAELSTPKTTSPFLNSSSRLRLSSKLHLSNHFRHLLLPPLHTTTPNSKISCSVSQNSQAPVAVQENGLVKTKKECYGVFCLTYDLKAEEETRSWKKLINIAVSGAAGMISNHLLFKLASGEVFGPDQPIALKLLGSERSIQALEGVAMELEDSLFPLLREVDIGTDPNEVFQDVEWAILIGAKPRGPGMERADLLDINGQIFAEQGKALNKAASPNVKVLVVGNPCNTNALICLKNAPNIPAKNFHALTRLDENRAKCQLALKAGVFYDKVSNMTIWGNHSTTQVPDFLNARINGLPVKEVITDHKWLEEGFTESVQKRGGLLIQKWGRSSAASTAVSIVDAIKSLVTPTPEGDWFSTGVYTDGNPYGIEEGLVFSMPCRSKGDGDYELVKDVEIDDYLRQRIAKSEAELLAEKRCVAHLTGEGIAYCDLGPVDTMLPGEV
What is the function of this protein?
The chloroplastic, NADP-dependent form is essential for the photosynthesis C4 cycle, which allows plants to circumvent the problem of photorespiration.  In C4 plants, NADP-MDH activity acts to convert oxaloacetate to malate in chloroplasts of mesophyll cells for transport to the bundle sheath cells (Probable).  Plays an essential role in the regulation of catalase activity and the accumulation of a hydrogen peroxide-dependent signal by transmitting the redox state of the chloroplast to other cell compartments (PubMed:24591715).
What are the official names of this protein?
Malate dehydrogenase [NADP], chloroplastic, NADP-MDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYM_BDEBA
Sequence: MNDKRKILITCALPYANGYIHLGHLVEYLQADFWARFQNMRGNECVFICADDTHGTPIMVKARELGITPEALIAQSYKEHTQDFADFQVQFSHFGSTNSEENRLLCEYFYKKMQEGNHTRSQPIQQMYCNHDKMFLPDRFVKGTCPKCGAKEQYGDSCDVCASTYSPSDMKDVHCSLCGTAPVMKDSESIFFKLNDFKQYLEEWIPKHCSPEISKKMLEWFNEDLKDLDISRDEPYFGFAIPGTNNKKFFYVWVDAPMGYMSTTEQWAKSQGKTLKDIWQDPSREIYHFIGKDIARFHTIFWPAFLKAAEFRSPNQVFVHGHLMVNGEKMSKSKGTFIAARTYLNHLNPEYLRYYYSTKLSSSVDDIDLNLEDFTNRVNSELVGKITNLGSRGGQMLKKKMDGKMSVPDAEGKKLIEHAQKTAESIAAHYEARDFAKALGEIRGLADDANKYFDEKAPWKTLEADPEGTKQVITTTLNMFRMLAIYLKPVLPFYSQKVAKLLGEKDYVWSDLNTVLTNREINDYEHLATRIEADKVKAMVEEGRKINEEIQAAKKAASTAKPAAAPAPAAAATAGDRPAEIEFADFDKVDLRIGQVIEAEEIKEADKLLRLKIDIGEGQIRQIISGIKAAYKPEQLVGRKVLVCVNLKPRKMKFGMSEGMVLAAGTGGSDLFVLSADDGAQVGQRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUSK_HUMAN
Sequence: MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV
What is the function of this protein?
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362).  Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex.  The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.  May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK.  DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering.  May positively regulate Rho family GTPases through FNTA.  Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression.  Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK.  May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).
What are the official names of this protein?
Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Single-pass type I membrane protein. Note=Colocalizes with acetylcholine receptors (AChR) to the postsynaptic cell membrane of the neuromuscular junction.
Protein: EFTS_STRM5
Sequence: MEITASLVKELRERTGAGMMECKKALTEANGDIDAAAEAMRKSGAAKADKKADRVAAEGRLGLAQDGGKAVLVEVNSETDFVANDVNFKNFVDSVAAAALASGANDVEAVKAAKLADGRTVEEARATAVQTLGENIQIRRMVKVDGNNTIGAYVHTNGKVGVLVDLVGGDVELARGLAMHVAALKPPHNKAADVPAEFVEKEKEIELAKMSEKDKAKPADILEKIISGKINKIVSDVTLYGQTYVLGDTTVEQVVKAAGADVAGFKLLVVGEGIEKVVEDYAAEVAKAMQV
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOH_SACEN
Sequence: MTNTAELLADDPIWLVLIKVVAIFAFLVVMTLFSIWAERRVIGRMQHRPGPNRAGPFGLLQSLADGLKLAFKEDIRPVLADKWVYFLAPVISATPALVAFSVIPIGGEVSVFGQQTALQLVELPVGLLVVLACASIGVYGIVLAGWSSGSPYPLLGSLRSAAQVISYEIAMGLSFVAVIMYAGTLSTSGIVEAQKDGWFALLLPFSFLVYVVSMVGETNRAPFDLPEAESELVGGFHTEYSSLKFALFFLAEYINMVTVSALATTLFLGGWHAPWPLSAIGGGVLNTGWWPVLWFLGKTLAFLFVFVWLRGTLPRLRYDQFMNLGWKFLVPLSLLWIIAVTVIRALRNNDAVTSQQFLIAGGVVIAVLLVATFLIPDRKVPESDGEVPLAGSGYPIPPLDLEVPKAPPRRSAVHAGAQAAPAGQLPGEGAGSTKEEPNGSV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HUTI_PSEAE
Sequence: MKRLWQHCHAATLKGGKYSIVEDAALVTDGPLIHWIGPRAELPPGDYAERIDLGGAWLTPGLIDCHTHAVFGGNRSGEFEQRLEGVSYAEIAAAGGGIASTVRATREASEEELLASARKRLEPLLRDGVTALEIKSGYGLDLASERKMLRVIRRLGERLPATVRSTCLAAHALPPEYAGRADDYIEHICSTMLPALAGEGLVDAVDAFCEHLAFSPAQVERVFIAARELGLPVKLHAEQLSSLHGSSLAARYRALSADHLEYMTEDDARAMGEAGTVAVLLPGAFYLLRETQLPPIDALRRHGVAMAIASDLNPGTSPALSLRLMLNMACTLFRLTPEETLAGVTLHAARALGLEASHGSLEVGKLADFVAWDIERPAELAYWLGGDLPKRVIRHAEEVYRG
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNS1_USTMA
Sequence: MSQQYSYGGGGGAGYPPPQMQPPNSYAQANYQGQPQGAQNQYYNGQQPHHNAPQQYYGNDYKQPLKPEGFEGERLQPKPKFRDPIFLVLFLLVFAGFIALSVICLRSYSNADVNVSIGRANVAGSTLNGHTAIMFMICCAVALVLSFVYILLVRTFPKIILEATLLLTTLSNVAFCVYLWVRGNTAAAIIFTIFAVLSVIAYFFMRKRIPLAKLILVTVIRTAEQYKSVYVVALGGLIVETAFSAWTSWVVVAAYQRFEPSGQAAGSSSSNASIIGIMVFIVFAYYWISEVIKNIAFTTVAGIFGVAYYNANKVANAAWGAFRRSMTYSLGSICFGSLIVAILDLLRALFNILQSQAASDGDMTGQILACVAGCCVSCIQGLVDYFNRYAYINIALYGNGYITAAKETWALLKDRGIDAIINDSLVNIVFNCGAFIIGLLTALFAFIYEQLTNPRYLQNDAGYYSIVLLVAFGLGFNIALSVGAGSIASGVSTYFVALAEDPYILQGKNPELFEMIRQQYPQVVQGVNH
What is the function of this protein?
Probably involved in transport through the plasma membrane.
What are the official names of this protein?
Protein PNS1.
What is the protein family that this protein belongs to?
Belongs to the CTL (choline transporter-like) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH10_PARPJ
Sequence: MNLRPLHDRVIVKRLDQETKTASGIVIPEAAAEKPDQGEILAVGPGKRDDKGAQIALDVKVGDRVLFGKYAGQTVKVDGNELLVMREEDIMAVVQK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QCRC_CORGL
Sequence: MAKPSAKKVKNRRKVRRTVAGALALTIGLSGAGILATAITPDAQVATAQRDDQALISEGKDLYDVACITCHGVNLQGVEDRGPSLVGVGEGAVYFQVHSGRMPILRNEAQAERKAPRYTEAQTLAIAAYVAANGGGPGLVYNEDGTLAMEELRGENYDGQITSADVARGGDLFRLNCASCHNFTGRGGALSSGKYAPNLDAANEQEIYQAMLTGPQNMPKFSDRQLSADEKKDIIAFIKSTKETPSPGGYSLGSLGPVAEGLFMWVFGILVLVAAAMWIGSRS
What is the function of this protein?
Cytochrome c1 subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis.  The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain.  The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
What are the official names of this protein?
Cytochrome bc1 complex cytochrome c subunit, Cytochrome c1, Cytochrome bc1 reductase complex subunit Qcrc, Menaquinol--cytochrome c reductase cytochrome c subunit.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.