PharMolix/UniProtQA huggingface dataset:
Protein: NTPPA_VIBCH
Sequence: MTISKLVLASGSPRRRELLAQMGYQFEVVVPNVEEKRAAAESPAQYVERLSRDKALAGAALVAAEAVVIGSDTIVVKDQQVLEKPRDFADAKRMLLKLSGSQHQVMTGVSVTCRGITHSVVVTTEVWFKTLSEQEIEAYWQSGEPCDKAGSYGIQGLGGRFVTRIEGSYHAVVGLPLYETDQLLHKF
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADEC_DEHM1
Sequence: MQTNLSQLIKVARGEAKADLVLLNARVVNVFNAEIEPANVAVFGGQIAGVGDYTLGNRVLDLKGAYLLPGLINGHTHVESSMLDISQYARAVIAHGTSALITDLHEISNVCGKEGIDYVLSASADLPLNIFLQVPSCVPATHLETAGAEINSNDVTELLRLPNVTGLGEMMNFPGVLFGIPSVLDKIEAASGKVLDGHAPGLSGKDLNAYISAGIHSDHECIQLDEAKEKLARGMYIMIREGSSEKNLTELLPLVTDKTYKRCIFVVDDRSCADLQRDGDIDAVVRKAIKLGLDPVRAIQLASINTAEYFRLNGHGAIAPGYLANMIVCQDLNQLDIDMVFHKGELVAEKGQVLFKPQSHVPKSLLSSMHIKPFDIKDLAIKGSSTQMPVIEVIPGQIVTRRLNLKIPAENGVLTPDIEQDLLKIVVLERHCQSGNIGRGLIKGFGLKKGAIASSVAHDSHNVIAVGTNDADIYTAVKELERINGGIALVVDGKISASVPLPVAGLLSTQPLEKVVDALEEINKQAAGLGCKLSAPFATLSFMALPVIPELRLTDLGLVDVNAFKLIPQET
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: Y3493_DICDI
Sequence: MLFKSLQSISSIKSVSQKSQLKNTISSSQFGSNSNQLLDVAACIDLNLAPLLSVHVDADISL
What are the official names of this protein?
Putative uncharacterized protein DDB_G0283493.
Protein: CTEC_CHRVO
Sequence: MLFFTGLQMIWIDKAMNISLSSAVAAASVSTASVGGVPHEITGGNRQEKLAQLMRQFESGGLYLRTVSDHRDEFENTFMPKLDACLGHGCDERYWSSATFIQQGLNGKVHDPHADRTGLIISADARLGGFSTFDAATANVPSGLEPSQYFPGQFPKFDMMGAYQATWNEDIFSVDATAVSEQQMDELGIPDEYRSVFDFDRIQEKMAQPRLAGREVEPTEAKICYQPKDVLGIYVDVDSPASQSKARELQQAMREQGFDLPFIAYRGGAAQELASV
What is the function of this protein?
ADP-ribosyltransferase that specifically modifies host ubiquitin on 'Thr-66' residue, which causes the shutdown of polyubiquitin synthesis and disrupts the recognition and reversal of polyubiquitin in host cells during infection (PubMed:32330457).  Threonine ADP-ribosylation of ubiquitin prevents the transfer of ubiquitin from ubiquitin-activating enzyme E1 to ubiquitin-conjugating enzyme E2, which inhibits subsequent ubiquitin activation and leads to the shutdown of polyubiquitin synthesis in host cells (PubMed:32330457).  The modification also causes dysfunction of polyubiquitin chains in cells, thereby blocking host ubiquitin signaling (PubMed:32330457).  ADP-ribosylation by CteC is likely irreversible (PubMed:32330457).  Plays a crucial role in bacterial colonization in mice during infection (PubMed:32330457).
What are the official names of this protein?
NAD(+)--protein-threonine ADP-ribosyltransferase, Adenosine diphosphate-ribosyltransferase, ADP-ribosyltransferase, Type III effector CteC.
Protein: UBIA_PSEAE
Sequence: MFVTLIKPLARLHPRAWDFVQLVRLDRPIGIYLLLWPTLWSLWIAADGVPELKNLLIFVLGVILMRAAGCVINDFADRNFDGHVARTKARPLATGKISVREAWITFAVLVALSFGLVLLTNATTVWLSFGAVAVASLYPFMKRYTYYPQVVLGAAYSWGILMAFTAERGELPASAWLLFLANVLWTVAYDSYYAMTDREDDLKIGIKSTAILFGDADRLIIGSLQGLTLLLLVLAGNRFELGLCFYLGLAVAAACFVWEAWSTRDRDPQACFRAFLHNHWAGLAIFLGTVADYALR
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CRP_MOUSE
Sequence: MEKLLWCLLIMISFSRTFGHEDMFKKAFVFPKESDTSYVSLEAESKKPLNTFTVCLHFYTALSTVRSFSVFSYATKKNSNDILIFWNKDKQYTFGVGGAEVRFMVSEIPEAPTHICASWESATGIVEFWIDGKPKVRKSLHKGYTVGPDASIILGQEQDSYGGDFDAKQSLVGDIGDVNMWDFVLSPEQISTVYVGGTLSPNVLNWRALNYKAQGDVFIKPQLWS
What is the function of this protein?
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine.  Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
What are the official names of this protein?
C-reactive protein.
What is the protein family that this protein belongs to?
Belongs to the pentraxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: FR1L5_HUMAN
Sequence: MLRLVVQSAKIDPPLAPLPRPCMSIDFRDIKKRTRVVEGNDPVWNETLIWHLWNRPLENDSFLQVTLQDMGSQKKERFIGLATVLLKPLLKQPSEVLFVKDLTLLNHSMKPTDCTVTLQVAHMSNQDIEKTGAEDHLGITAREAASQKLMVPGSTAHRALSSKPQHFQVRVKVFEARQLMGNNIKPVVKVSIAGQQHQTRIKMGNNPFFNEIFFQNFHEVPAKFFDETILIQVVNSSAMRYKAEIGRFQTDIGFIYHSPGHTLLRKWLGLCQPNNPGSGVTGYLKVTIYALGVGDQALIDQKLLYGTDDTDIQIFKSAVVPINMAYLQLFIYCAEDLHLKKHQSVNPQLEVELIGEKLRTHMQTQTDNPIWNQILTFRIQLPCLSSYIKFRVLDCRKKDCPDEIGTASLSLNQISSTGEEIEGVYSGFLPCFGPSFLTLHGGKKAPFRIQEEGACIPDSVRDGLAYRGRVFLELITQIKSYQDSTIKDLSHEVTRIEKHQNRQKYGLCVIFLSCTMMPNFKELIHFEVSIGHYGNKMDLNYKPLVSSTPYSPVIYDGNIYHYVPWYNTKPVVAVTSNWEDVSFRMNCLNLLHFTRDRLKANLDTLKSTRNPKDPALLYQWEKLLRELAEDCKRPLPCMTYQPKATSLDRKRWQLRSLLLQELAQKAKQAKPKDMVATAEDWLYRLNTVLPEPQMGLPDVMIWLVAKEQRVAYAQVPAHSVLFSPAGALHSGRLCGKIQTLFLQYPEGEGQKDVLPAHLRVCMWLGNVTDSKDLQLLRQGDTAVYAEMYENQAKYKDQWGQQGLYHCPNFSDVMGNKTLPMTDFQPPLGWHWQDSWTVEPQRRLLLDIDINKSQVLEEVYENQGRDTRGAWGPAAIPNTDVNGQPMEARENVKCPQGWHFKKDWVVELNHAVDSKGWEYGVGIPPSGLPQVWSPVEKTYHSCRRRRWARVRFRNHGELSHEQETLSFLQLGLAKGEEEGWEYDTFGSKFHLNPQPQSRFRRRCWRRRLAPNKDKGIAPIFLLEGSLAMDLKYHAGKEEDSKTWPWGLDRQFRDPQRQDTRPPNLPFIYCTFNKPHYYQLFCYIYQARNLVSNQILTFQGPFIRVVFLNHSQCTQTLRSSAGPTWAQTLIFQHLLLYENPQDTKESPPLVVLELWQRDFWGKESLWGRSVWPPMVWLDLQDRILPPMRWHPLVKELGKEEGEILASCELILQTEKLGEKQLPILSVPWKNGAYTLPKSIQPTIKRMAIEILAWGLRNMKKASSPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVVDNWAFGQQTVTGQANIDFLQPYFCDPWAQDYMHPKLPTLSEKKHQDFLGYLYRKFWFKSSKAEDEYEHEVDWWSKLFWATDEHKSLKYKYKDYHTLKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSPVVGEFKGLFRIYPFPENPEAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGLCDPYVILKLGKTELGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDKIGTTVIDLENRLLSGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSPEEDAVFYNGKKFKLQSFEPKTPTVHGLGPKKERLALYLLHTQGLVPEHVETRTLYSHSQPGIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRYELRCIIWKTANVDLVDDNLSREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAERTCVQSQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQCSIRMMDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVLDGGKWRLSGKVKMSLEILSEKEALIKPAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIALMLFNFIYSAPHYLAMSWIKPQLQLYPPIKIFNIINSLNTSNASSSILPTQDPNLKPTIDHEWKLHPGPTNHLSDIFPELPAPGD
What is the function of this protein?
Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.
What are the official names of this protein?
Fer-1-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the ferlin family.
What are the subcellular locations of this protein?
Cell membrane. Membrane; Single-pass membrane protein. Note=Colocalizes with EHD1 and EHD2 at plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane (By similarity).
Protein: PURA_AZOC5
Sequence: MANVVVVGSQWGDEGKGKIVDWLSEQADVVVRFQGGHNAGHTLVVDGVTYKLSLLPSGVVRPGKLSVIGNGVVLDPQALVDELARLESQGVHVGPDRLRIAENTPLILPLHRELDALRENASEGTRIGTTKRGIGPAYEDKVGRRAIRLVDLVDPKALPAKVERLLTHHNLIRRGLGVEEVNPQALVDELLALAPKVLPYMDRVWELLDKARKDGKKILFEGAQGALLDIDHGTYPYVTSSNTVASSAAGGSGVGPGALDYVLGITKAYTTRVGEGPFPTELTDEVGKTLGTKGREFGVVTGRPRRCGWFDAVLVRQTVRTCGIHGIALTKLDVLDGFDEIKVCVGYKLDGKEIDYFPSEMGAQARVEPIYETIEGWTDSTAGARSWADLPAEAVKYVRWLEELIGCPVAVLSTSPERNDTILVHNPFQA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIAH_STRR6
Sequence: MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENARADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTNIKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLETLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRIHRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGFGLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK
What is the function of this protein?
Member of the two-component regulatory system CiaH/CiaR.  Involved in early steps of competence regulation and in penicillin susceptibility.  Probably phosphorylates CiaR.
What are the official names of this protein?
Sensor protein CiaH.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CRE2A_XENLA
Sequence: MNGSRALHLSAWLLLCLLCSAAVARDDSCETCRKLVDRFHKGLENTAKKNFGGGNTAWEEKTLSKYESSEIRLVEIIENLCDSSDFECNHMVEEHEEQIEKWWFKMKKKYPDLLKWFCIETIKVCCPPGTYGPDCLACLGGSERPCHGNGFCNGDGTRSGDGLCRCEAEYTGPFCLECADEYFSSERNDTYSLCTACNQACKTCDGPSNEDCKECKNGWIKDDGKCVDLNECASEESPCKDSQYCLNTEGSFLCKECDGSCLGCSGEGPENCKDCATGYVLLAEKCTDVDECDASEQVCSRENETCLNTAGSYKCTCSEGFEDKEGNCVKIMEAENTEVTDGEMGTSASDINISNTAHEDL
What is the function of this protein?
Possible role in neuronal acetylcholine receptor transport.
What are the official names of this protein?
Cysteine-rich with EGF-like domain protein 2-A.
What is the protein family that this protein belongs to?
Belongs to the CRELD family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum.
Protein: ASPR_CUCPE
Sequence: MASYHSKAAFLCLFLLVSFNIVSSASNDGLLRVGLKKIKLDPENRLAARVESKDAEILKAAFRKYNPKGNLGESSDTDIVALKNYLDAQYYGEIAIGTPPQKFTVIFDTGSSNLWVLCECLFSVACHFHARYKSSRSSSYKKNGTSASIRYGTGAVSGFFSYDNVKVGDLVVKEQVFIEATREPSLTFLVAKFDGLLGLGFQEIAVGNAVPVWYNMVEQGLVKEPVFSFWLNRNVEEEEGGEIVFGGVDPKHYRGKHTYVPVTQKGYWQFDMGDVLIDGEPTGFCDGGCSAIADSGTSLLAGPTPVITMINHAIGAKGVVSQQCKAVVAQYGQTIMDLLLSEADPKKICSQINLCTFDGTRGVSMGIESVVDENAGKSSDSLHDGMCSVCEMTVVWMQNQLRQNQTKERIINYINELCDRMPSPMGQSAVDCGQLSSMPTVSFTIGGKIFDLAPEEYILKVGEGPVAQCISGFTAFDIPPPRGPLWILGDVFMGRYHTVFDFGKLRVGSAEAA
What is the function of this protein?
Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles.
What are the official names of this protein?
Aspartic proteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: GSTT2_ANOGA
Sequence: MLDFYYLPGSAPCRAVQMVAEAVHVKLNLKYLDLMAGAHRSPQFTKLNPQRTIPTLVDGSLILSESRAALIYLCDQYGDEDNDWYPRDTIQRAIVNQRLFFDACVLYPRFADFYHPQVFGNAAPDGRKRLAFEKAVELLNIFLSEHEFVAGSKMTIADISLFATLATACTLGFILRPYVHVDRWYVTMVASCPGAQANVSGAKEFLTYK
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 2, Aggst1-2, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: MNMG_GEOMG
Sequence: MEFIDYDKQYDVIVVGAGHAGCEAALAAARMGCETLLLTINLDAIALMSCNPAIGGSAKGHLVKEIDALGGEMGKNIDATGIQFRILNTRKGPAVRASRAQADKQLYRLRMKHVMEQQERLSLKQAEVTGIVVEDGEVRGVDTKVGVRYLGATVILTTGTFMRGLIHVGLTNYPGGRAGDLPSVGLSDQLRELGFAVGRLKTGTPARLDGRTIDFTRLEPQHGDDPPVPFSFSTERIDQPQVPCYIAYTNPRSHEIIRSGLDRSPLYAGVIEGIGPRYCPSIEDKVVRFPEKDRHQTFLEPEGRDTVEYYPSGLSTSLPIDIQWAFYRSIEGLERVEIMRPAYAIEYDYVDPIQLHASLETKLVRNLYHAGQINGTSGYEEAAGQGLMAGINAALRVRDKEPLILGRSEAYIGVMIDDLVTLGTREPYRMFTSRAEYRLLLREDNADLRLRERGHAVGLVPEGAYQRFLEKRERIGAELARLKGTKLLPSEADPDFLAAFSLTALQNALTYEQLLRRPDITYEELCRIDPRAAEVPPVVREQVEIQIKYQGYIERQLDQVERARKLEGTRVPAGFDYGALPGLSAEVREKLAKFRPDTLGQASRIQGVTPAAVGILSLALKARG
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_FRAP2
Sequence: MTNLSVIAKPYAKAAFEFANEYNLLQEWSKQLKSFAELVQDDAIAAIISSPEISQTEIINTVKDQLDEKFFNFVALVAENKKLSILPEISFQFENIRNVHNNIKVADVTLAYAIDKNTLANLKTKLEEKFSCSIDMNVIIDPVILGGAVIKVGDTVIDDSVSGRIETLKSILLS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RPPH_LEGPL
Sequence: MVIDRAGYRLNVGIILVNDSDRVFWGRRSGHDAWQFPQGGLAPGETAMQAMYRELHEEVGLDKGDVEILGSTRRWLKYRLPKQYLRHGSEPLVIGQKQKWYLLKLVTSEQKVRLDLSDSPEFDSWRWVDFHEPEQQVIFFKRQVYIQALKELEPLLKKERRTPYGLKRKRGNQRA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: SYT_UREPA
Sequence: MYKFDQKLNHSAAHLLAMALTKFYPNLSLAIGPTIDEGFYYDFNLNDPNTSITPLDLLKIEKEMKKITTQALTFDYEQVTYEKAKELFKHNKYKLDIIEQNKNNSLSIYHSGKWFDLCKGPHVQNTKEIKAIKLLNIAGSYWRGDANNDQLIRIYGVAFSDQDQLDAYLKDLQERKERDHRKIGKDLNLFTFNNLAGQGLPIWLPNGTIIKNQVQKFINEVEFQFNFDTVITPILGSIDLYKTSGHWDHYKDNIFSPVQIDNEILVLRPMTCPHHTLVYSNELRSYRSLPIRLSEHSILHRYESSGGLTGFERVREMILEDCHVFCRFDQIEHEVINAFKMIQEAQEGLGIKTFEIHLSLNDPNDKEKYYDDPQMWEQSQNVLRKMLKDHNIPYKEMVGEAAFYGPKIDFQVKTVLNRIITVSTIQLDFLLPNRFNLTYINESNEQSVPVMIHIGIIGTYERLLAILLEQTKGILPLWLSPIQVVIIPVNENLHTDYVKELNIKLRKHLIRSNVDLRNERLSKKIREAQIQKIPYQIVIGDEEIKNNKMVTYRCYGSEKTTTVSITDFINMLENKIRLKK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_VIBCH
Sequence: MTTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDDYSWSDAIRELRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVANPDAQLYDKLAYNDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLISDVQ
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_AGRFC
Sequence: MKIKNSLKALKARHRDNRLVRRKGRVYIINKQNPRFKARQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LPXC_LEPBP
Sequence: MQTVIHRKTIQNSVTLKGIGVHSGKVVTLRLHPAEANTGLIFYLYKGIQKIRIPVSLDHVVDTSNATTIGDGSSNRVQTIEHLLAAVHTLGITDCIFEIDSVEVPIMDGSSLPFWEGIRSAGIRVLEETIEPITITNPIWVVDGDKYLVMLPSDELKVTYSIDFNHPLLRGQSYTTTLDESILGTDILPARTFGFLKDVEALQARGLAMGGSLDNAVVLTDDGYLNDHLRYDNECVRHKILDLVGDLAVMGRPFRGHLIASKAGHALDISLAKCIMSQVTGNELTQYKSKRIPLFSKKEAAK
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: DC1L2_MOUSE
Sequence: MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLRETLVIFVADMSRPWTIMESLQKWASVLREHIDKMKIPPEEMRDLERKFMKEFQDYIEPEEGCQGSPQRRGPLTSGSDEDSVALPLGDNVLTHNLGIPVLVVCTKCDAMSVLEKEHDYRDEHLDFIQAHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTIPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRTSESPARGPSGSPRTQGRGGPASVPSASPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPSAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVTNSSTENEA
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in binding dynein to membranous organelles or chromosomes.
What are the official names of this protein?
Cytoplasmic dynein 1 light intermediate chain 2, Dynein light intermediate chain 2, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the dynein light intermediate chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: STHA_YERPN
Sequence: MQQHFHFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDNARTIKSSFADILNHADRVINQQTRMRQGFYDRNHCHMFSGDASFIDANTVNVRYADGTSDTLQADNIVIATGSRPYRPVNVDFNHERIYDSDTILQLSHEPQHVIIYGAGVIGCEYASIFRGLSVKVDLINTRDRLLAFLDQEMSDALSYHFWNNGVVIRHNEEFEQIEGTTDGVIVHLKSGKKVKADCLLYANGRTGNTSGLGLENIGLEADSRGLLKVNSMYQTALSHVYAVGDVIGYPSLASAAYDQGRIAAQAMIKGEANVHLIEDIPTGIYTIPEISSVGKTEQELTAMKVPYEVGRAQFKHLARAQIVGMDTGSLKILFHRETKQILGIHCFGERAAEIIHIGQAIMEQKGEGNTLEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT2J_HETCR
Sequence: GFYFRSIQGFYFKRIQGNICSEPKKVGRCRESFPRFYFDSETGKCTPFIYGGCGGNGNNFETLHACRAICRA
What is the function of this protein?
Serine protease inhibitor that acts on trypsin (Ki=190 nM) and to elastase (PubMed:32144281).  Does not bind to alpha-chymotrypsin, cathepsin G, and kallikrein (PubMed:32144281).  It significantly increases neuroblastoma cell viability in an in vitro neurotoxicity model, being a consequence of an effective decrease of reactive oxygen species (ROS) level in the cells (PubMed:35563513).  It also protects cells by inhibiting ATP-induced purinoceptor activation (PubMed:35563513).  Its binding affinity to P2RX7 is moderate (Kd=45. 5 uM) (PubMed:35563513).
What are the official names of this protein?
PI-stichotoxin-Hcr2j, PI-SHTX-Hcr2j, Kunitz-peptide HCIQ4c7.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: NUOK_RICPR
Sequence: MLKILNMNEYISLNHYLILSSLVFTIGMFGLFMNRKNIINILMSIELMLLAVNINFVAFSVYMQELSGQIFSIIILTVAAAETAIGLAILLIYFRNKGSIKITDINKMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IRF3_HUMAN
Sequence: MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES
What is the function of this protein?
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:24049179, PubMed:31340999).  Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995).  Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431).  Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953).  This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148).  Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591).  In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812).  Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).
What are the official names of this protein?
Interferon regulatory factor 3, IRF-3.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812).