PharMolix/UniProtQA huggingface dataset:
Protein: AROK_MYCPA
Sequence: MAPKAVLIGLPGSGKSTIGRRLAKALGVGFLDTDAAIEQRTGRPIAEIFATDGEREFRRIEEEVVRAALTEHDGVLSLGGGAVTSPGVREALAGHTVVYLEISATEGVRRTGGNTVRPLLAGPDRAEKYRALLAERSPLYRRAATIRVDTNRRNPGAVVRYIVSRLPATDACRAAT
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADA_BACC4
Sequence: MSILEQVQPIETMLPERYYTMSTEDMEKRVREIKEKMGKMLFIPGHHYQKDEVVQFSDAAGDSLQLAQVAASNKDAKYIVFCGVHFMAETADMLTTDDQVVILPDMRAGCSMADMADIEQTERAWKELTKLFGDTMIPLTYVNSTAAIKAFCGRNGGATVTSSNAKQMVSWAFTQKERLVFLPDQHLGRNTAYDLGIPLDKMAVWDPHTDSLEYDGDIEEIQVILWKGHCSVHQNFTVKNIESIRKNHPDMNIIVHPECCYEVVAASDYAGSTKYIIDMIESAPSGSKWAIGTEMNLVNRIIQQHPDKEIVSLNPFMCPCLTMNRIDLPHLLWALETIERGEEINVISVDKQVTTEAVFALNRMLERV
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UP03_METAN
Sequence: ADETCTDLTILTTQYIAGDFD
What are the official names of this protein?
Unknown 33 kDa protein.
Protein: BTAE_BRUSU
Sequence: MFGLSVNHAYAGPGIFINDGTDDGCIWTFDKEDYSPIGDYFGNTAPADKDSAGRNSPASVKYHIPSIQQLGGAATLKCLSKDRDTQTDRVLFYGNSKEQGSISLTLGGELFVNNGNLGLGGGTDTKAMRIGSMATLTGPSGLRSLAIGAGEIATVASGDDAIAIGTAAQAAHVGSIALGLQSTTELPSLVKDVTINGIKLSAFAGSNPASVLSIGNDTLKRSITNVGAGRVSKDSTDAVNGRQLFAVSEQAASGWSLTVNGMDKSRVGPGDTVDLSNSDGNLVLSKKGKDVTFNLASDLKVTSLVAGNTFLDTNGLVITGGPSMTVSGIDAGQLKISHVADGAVTVTSTDAVNGSQLHRVAHTIAEHLGGDAHVNADGSVIGPQYTVQKKRYKTIYDAFGGVDENLANINDILHDIESGGGIKYFHANSIGADSRALGTNSIAVGSDSVASGEGSISVGNGAQASAHGSVALGENAAAPDANSVALGAGSKTSEVVATKGTTINGQYYDFAGDAPSGTVSVGDKGAERTITNVAAGRISVESTDAVNGSQLNAVNQAIENLAAGVTENDKFSVKYDRHSDGTKKNSMTLQGWDSATPVVLANVADGVHKNDAVNVSQLKAGLSTTLGEAKAYTDQTALQTLDQANAYTDKKFGKLNEDIVATRIEARQAAAIGLAAASLRYDDRPGKISAAIGGGFWRGEGAVALGLGHTSEDQRMRSNLSAATSGGNWGMGAGFSYTFN
What is the function of this protein?
Binds to hyaluronic acid and epithelial cells, and is required for full virulence in the mouse model.
What are the official names of this protein?
Autotransporter adhesin BtaE, Brucella trimeric autotransporter, Type 5 secretion system autotransporter BtaE.
What is the protein family that this protein belongs to?
Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
What are the subcellular locations of this protein?
Cell surface. Cell outer membrane. Note=The C-terminal translocator domain is localized in the outer membrane and the passenger domain is at the cell surface (By similarity). Localizes at the new cell pole generated after cell division (PubMed:23319562).
Protein: UTP23_MOUSE
Sequence: MKITRQKHAKKHLGFFRNNFGVREPYQILLDGTFCQAALRGRIQLRDQLPRYLMGETQLCTTRCVLKELETLGKELYGAKLIAQKCQVRNCPHFKSPVSGSECLLSMVDEGNPHHYFVATQDQNLSVKVKRTPGIPLMFIIQNTIVLDKPSPRTVAFVKAVEAGQLVSVHEKQSIKQLKEEQGLVRNPDLRRRRRKKKKVGGPNPLSCLKKKKKAQDTKSPASEKKRKRKRIRNRSTLKVSSEQQGAEG
What is the function of this protein?
Involved in rRNA-processing and ribosome biogenesis.
What are the official names of this protein?
rRNA-processing protein UTP23 homolog.
What is the protein family that this protein belongs to?
Belongs to the UTP23/FCF1 family. UTP23 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NRDR_SORC5
Sequence: MKCPFCGHLEDRVIDSRAGGAGEVIRRRRECASCERRFTTYERVEDILPTVVKKDGRRESFDRQKLVRGLRIACNKRPVSTDQIEAIADAIEREAQESERREILSTELGERVMNHLRTLDEVAYVRFASVYRSFRDIDQFMVELGKLVKAKAP
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: MMDC_PROMO
Sequence: MKNFKVTVNGTEYDVAVEEMGGAAVASAPAARPAAAPAPAAPKPAAAPAPAPAPKTTAAGAGAGANTVTAPMPGTILNVGCHAGDKVSKGDTLVVLEAMKMENEIMAPHDGVVSEVRVQQGASVNAGDILVVLS
What is the function of this protein?
Biotin-containing subunit of the sodium ion pump methylmalonyl-CoA decarboxylase, which converts the chemical energy of a decarboxylation reaction into an electrochemical gradient of Na(+) ions across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.
What are the official names of this protein?
Methylmalonyl-CoA decarboxylase subunit gamma.
What are the subcellular locations of this protein?
Cell membrane.
Protein: IVBI3_HOPST
Sequence: MSSGGLLLLLGLLTLWEVLTPVSSKDRPEFCELPADPGPCNALSQAYYNAVQHKCLKFRYGGCKANPNTFKTIEECKRTCAGK
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Stephenin-3.
What are the subcellular locations of this protein?
Secreted.
Protein: TRML_SHEPW
Sequence: MFHIALYEPEIAPNTGNIIRLIANNGCQLHLIEPLGFDLEDKKLRRAGLDYADLANVSHHKNFESFLKAMQGKRIMACTTKGSRPHSELTFQQDDVLLFGPESRGLPADIIDSIPTEQRLRIPMMSTSRSLNLSNAVAIISYEAWRQLDYSGT
What is the function of this protein?
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA).  Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
What are the official names of this protein?
tRNA (cytidine(34)-2'-O)-methyltransferase, tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD476_YEAST
Sequence: MWDSLIVSINDTHKLGLEDCLAVFGHVPITKAVKHVRLTEIDTQTSTFTLKFLHTETGQNIEKIIYFIDNDTGNDTRTATGIKQIFNKMFRIAAEKRKLSLIQIDTVEYPCTLVDLLILVGVALPPLCYLYRPALHAIFFLVPNPVGSTLEAWLDSDLVLRLIIVAEFLTHALETLIFVVPRLKYYRVPGEFVPEWLLLGLLEGYGPARRLDTKARTLGEGSVN
What are the official names of this protein?
Uncharacterized protein YDR476C.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: TPS2_APHAV
Sequence: MTVVPGETQCEEAQPAANGSSSPVLLQPFRRPRTDSRSRLDSGSNNTTLSEDCARKSILRTLKSLGVEIDESASFEAIIDSGGIEKLADFWRKRDSSSEIAFQGLLSVLEYCLQHSFDTNEFFEKFVNALGYHTVQFWRAGVPYVFDSDMSHGTKYRDALLFSLTLYDVNTGKSRLKELYAAVPGIRKSLLGVHAKRFGEQYHHLQRRRSVSSRGGSLRGSMDSLNDSGQNGAEDVIGVEDEEEAQKFRGKRTSISLDPAAAGEVMFTIEDGACFPSGGLANTHFQQRVINVSNAPPVSLKREKSGEWEIKQGSGGLVSCVDPIMSVNQENMWLANLGMNIDKKKMLRYDDCLRSQEHTLENMRSTELLNVTDDSAPLAPATNTLGLPLMRQALADVLFHVIADDDIKEQNEDEQSRNVREEMSLLGVLNQYNRSNYKLNPVVVQEQDYNVYYGGISNGLLWPALHNLPEYIVADYDDPKVLYEHWCAYVRVNYQFAIDAVRNSRPQDFIWIHDYHLMLTGMIMQSLDSSLEIGFFLHIPFLPPDNFFTKYRLCAFPIMRGLLRFTKVGFQTHRDRAKFVELVGIHLPTARVTYDEKMDIHTVTYQGWSCSLGVFPVSIKNEDFLKVAQSAETIKKADDIRKEILGETPVDSARLLFSVERFDYTKGIKEKLLAYRRYFERHPDRIGKDVLYQVAVTNRRSVDTYRMYQDECIQMAEDINKEFATDEYPNWKPLIFRTDGLQRADLVAHYLAMDVGVVTPKKDGMNLVAKEMLVCNPSAGLVLSTGAGSEIQFTMAGLHPDDGDKCYHRVVDVYDADHYADAFYEAAVEPEAERAAHGQRLNEFIMNNDIERWSTAFLDPGWSHLVIRQSEIKDLDDFYSLMMRTRDVRRQIVERVLKGIPIRSHFSISLSNAKESLLLACQPGTRTLHLKPSLEEDEQTEPAHFDIANELDEFEKDLNFMKFIQSDDVYNVEQFINSLQEYHPVSADKFRDEVIELGDMLTEADHFNFFFTDRDGTLKSYSCSYPASIQPAYSGVIQAQFARRCAQTCAIVTTAPLMRIGVLDVSTIPEGYYYFGASAGREWFIDPANKFKDQSIPEEDLELLERVFAAISDLLEEPKFKHFTWVGSGLQKHYGHITIAHQDAFNSVPRHQVRAIDQKIKDIIHRIDPDQHTLKVKETETDIKIFLKSESGEIFDKGQGIRLLVEHMKCDISNGTILVCGDSSTDLPMLQACLEANPSGVYTVWVTRSDELKTTVRELCERFGNKNFVFVSCPEVLLGGMAQATIREISIGRPGPRASHDSE
What is the function of this protein?
Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.
What are the official names of this protein?
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2, Trehalose-6-phosphate synthase 2, UDP-glucose-glucosephosphate glucosyltransferase 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.
Protein: CYB_CHIIN
Sequence: MTIMRKKHPLLKLINNSFIDLPTPSNISSWWNFGSLLGICLAIQILTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYMHANGASMFFICLFIHVGRGIYYGSFMLLETWNIGIILLLTTMATAFVGYVLPWGXXSFWGATVITNLLSAIPYIGNTLVEWIWGGFSVXKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPAGLNSNSDKIPFHPYYTTKDLLGALLLLMVLMILVLFFPHILGXPDNYTPAKPLXTPAHIXPEXYFLFAYAILRSVPNKLGGVLALILSILILATLPILNSSKQHGLIYRPITQTLYWIFITNILVLTWIGGQPAEYPFTTIGQVSSILYFTIIIILMPITNTVENNILKLH
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DNAJ_CERS4
Sequence: MAKRDYYEVLGVSRTASADELKKAYRTKAKELHPDRNADNPQAEAQFKEVNEAYDVLRDADKKAAYDRYGHAAFEGGMGGGARAGGGYGQQGDFASAFSDVFEDLFGDFMGGRGGAPRSRAQRGSDLRYNLRVTLDEAYRGVQKTINVPASVACDACKGTGAEGGAEAVTCPTCSGMGKVRAQQGFFTVERTCPTCNGMGQIVKNPCKVCHGAGRVEKERSLSVNIPAGVETGTRIRLAGEGEAGMRGGPSGDLYIFIEVREHALFQRDGVHLFCRVPVSIAAAALGGEVEVPTIDGGSSRVKIPAGSQTGKQMRLRGKGMPALRGGGAGDMLIELAVETPVNLTARQKELLREFEKLSEDNNPEGKSFFSKVKGFWDGMTG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_PARUW
Sequence: MLYPLSILTSEKNVFNEDVYSVNVPGADGYFEVLAHHATVIALLQPGKLTIINKDHQKLYFGITTGFIEVSHNSATIIADAIESVQEIDVERAKQSYERAKMRLESPDKHVDKERAKRSLNRAKNRIKLFLEIHPQVSFIPLKALLI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL19_CHLAB
Sequence: MGNLIKELQEEQLRKEILTDFCVGDTIRVATKIVDGGKERTQTFQGTVMARKGGGAGEVISLHRVAYGEGMEKSFLLHSPKIVGIEVVKRGKVSRARLYYLKGKTGKAAKVKEYIGPRSAKK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PSBA_GOSBA
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRLGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNLPLDLAAIEAPSTNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CXY17_CONCB
Sequence: MQKATVLLLALLLLLPLSTAQDAEGSQEDAAQREVDIATRCGGTGDSCNEPAGELCCRRLKCVNSRCCPTTDGC
What are the official names of this protein?
Conotoxin ca17a, Conotoxin ca16a.
What is the protein family that this protein belongs to?
Belongs to the conotoxin Y superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2488_GEOTN
Sequence: MSSFDQTMQFHFPEEPAETNVREVLLTVYDALQEKGYNPINQIVGYLLSGDPAYIPRHKDARTLIRKIERDELIEELVKFYLQGQRKG
What are the official names of this protein?
UPF0297 protein GTNG_2488.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: ALBU1_SALSA
Sequence: MQWLSVCSLLVLLSVLSRSQAQNQICTIFTEAKEDGFKSLILVGLAQNLPDSTLGDLVPLIAEALAMGVKCCSDTPPEDCERDVADLFQSAVCSSETLVEKNDLKMCCEKTAAERTHCFVDHKAKIPRDLSLKAELPAADQCEDFKKDHKAFVGRFIFKFSKSNPMLPPHVVLAIAKGYGEVLTTCCGEAEAQTCFDTKKATFQHAVMKRVAELRSLCIVHKKYGDRVVKAKKLVQYSQKMPQASFQEMGGMVDKIVATVAPCCSGDMVTCMKERKTLVDEVCADESVLSRAAGLSACCKEDAVHRGSCVEAMKPDPKPDGLSEHYDIHADIAAVCQTFTKTPDVAMGKLVYEISVRHPESSQQVILRFAKEAEQALLQCCDMEDHAECVKTALAGSDIDKKITDETDYYKKMCAAEAAVSDDSFEKSMMVYYTRIMPQASFDQLHMVSETVHDVLHACCKDEQGHFVLPCAEEKLTDAIDATCDDYDPSSINPHIAHCCNQSYSMRRHCILAIQPDTEFTPPELDASSFHMGPELCTKDSKDLLLSGKKLLYGVVRHKTTITEDHLKTISTKYHTMKEKCCAAEDQAACFTEEAPKLVSESAELVKV
What is the function of this protein?
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs.  Its main function is the regulation of the colloidal osmotic pressure of blood.
What are the official names of this protein?
Albumin 1.
What is the protein family that this protein belongs to?
Belongs to the ALB/AFP/VDB family.
What are the subcellular locations of this protein?
Secreted.
Protein: M1_I01A1
Sequence: MSLLTEVETYVLSIIPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYKKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTTEVAFGLLCATCEQIADSQHRSHRQMATTTNPLIRHENRMVLASTTAKAMEQVAGSSEQAAEAMEVANQARQMVQAMRTIGTHPNSSAGLRDNLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: NUSB_MYCPA
Sequence: MSKPLRGRHQARKRAVDLLFEAEARGLSPAEVVDVRTGLADTNPEVAPLQPYTAAVARGVGDHAAHIDDLISSHLQGWTLDRLPAVDRAILRVAVWELLYADDVPEPVAVDEAVQLAKELSTDDSPGFVNGVLGQVMLVTPQIRAAARAVRGPRDT
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: HSP90_EIMTE
Sequence: MENKETFAFNADIQQLMSLIINTFYSNKEIFLRELISNASDALDKIRYEAITEPEKLKTKPELFIRLIPDKANNTLTIENSGIGMTKADLVNNLGTIARSGTKAFMEALQAGGDISMIGQFGVGFYSAYLVADSVTVVSKHNDDEQYVWESAAGGSFTVQKDDKYEPLGRGTRIILHLKEDQGEYLEERRLKDLVKKHSEFISFPIELAVEKTHEREVTESEDEEEKKADEKAEEKEGEEKKEGEEKKEGEEEKKEKTGKTKKVQEVTREWEQLNKQKPLWMRKPEEVTEEEYASFYKSLSNDWEEHLAVKHFSVEGQLEFKALLFVPKRAPFDLFETRKKRNNIKLYVRRVFIMDDCEDIIPEWLNFVKGVVDSEDLPLNISRESLQQNKILKVIRKNLVKKCLEMFAEIEEKKENYAKFYEQFSKNLKLGIHEDSANRAKIAELLRFHSSKSGEDMVSFKEYVDRMKEGQKDIYYITGESRQTVANSPFLEKLTKKGYEVLYMTDPIDEYAVQQLKEFDNHKLRCCTKEGLEIDESEEEKKKFEELKAEFEPLLKLIKEVLHDKVDKVVLSNRITDSPCVLVTTEFGWSANMERIMKAQALRDNSMTSYMVSKKTMEVNGHHSIMIEIKNKAAVDKSDKTVKDLIWLLYDTALLTSGFSLEEPTQFAARIHRMIKLGLSIDDDEEAKDDDLPPLEEVEGAADEASKMEEVD
What is the function of this protein?
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.  Undergoes a functional cycle that is linked to its ATPase activity.  This cycle probably induces conformational changes in the client proteins, thereby causing their activation.  Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
What are the official names of this protein?
Heat shock protein 90.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_TREDE
Sequence: MNNKKDYYLPFLLTAIVIVVDQVTKILVVQYMSVNEVIPVIGDLVNLRFVYNTGAAFSLGAGFGEIARKILLVFLPFLLLIALTGAYLKSAELTRAQRWFICGILGGGFGNLIDRFFRSEGVVDFIDVKFFGILGMERWPTFNAADSFIVCCGIGLGVNLILQGIKQKKLKDS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CP2CJ_HUMAN
Sequence: MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768).  Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576).  Also metabolizes plant monoterpenes such as limonene.  Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794).  Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.  Hydroxylates fenbendazole at the 4' position (PubMed:23959307).
What are the official names of this protein?
Cytochrome P450 2C19, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Fenbendazole monooxygenase (4'-hydroxylating), Mephenytoin 4-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: PQQE_XANCB
Sequence: MSTVPPPLSVLLELTHRCPLACPYCSNPIALAALREEMDTAGWRSLLEQAAEMGVLQAHFSGGEPMLRKDLPELVAHARALGLYSNLITSGVAGGEPMLDQLQAAGLEHVQLSVQDVDPAGADHIAGYRNSLSKKRAFAAAVRARGLPLTLNAVIHRHNAERVPGMIALALEWGAERIEVAHTQYYGWGLRNRAALMPSREQLAATIVAVETARRSLGDQLAIDFVTPDYYARQPKPCMGGWAQRFVNISPRGDVLPCHAAETIDGLQFEKLRDRSLADIWNHGEAFARFRGTAWMPEVCQGCPKREIDWGGCRCQALALAGDAATLDPVCERSPAHAGIRATAEREAASPAPDFIYRRPERPAAVAAEAAISDTE
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: BUB3_PONAB
Sequence: MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMATGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFLNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKSPCT
What is the function of this protein?
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments.  Promotes the formation of stable end-on bipolar attachments.  Necessary for kinetochore localization of BUB1.  Regulates chromosome segregation during oocyte meiosis.  The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20.  This complex can also phosphorylate MAD1L1 (By similarity).
What are the official names of this protein?
Mitotic checkpoint protein BUB3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BUB3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.