PharMolix/UniProtQA huggingface dataset:
Protein: CCR6_HUMAN
Sequence: MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM
What is the function of this protein?
Receptor for the C-C type chemokine CCL20 (PubMed:9169459).  Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036).  Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877).  Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels.  Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636).  Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036).  The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases.  CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174).  CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation.  Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine.  Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs).  Required for optimal differentiation of DN2 and DN3 thymocyte precursors.  Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches.  Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity).  Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).
What are the official names of this protein?
C-C chemokine receptor type 6, C-C CKR-6, CC-CKR-6, CCR-6, Chemokine receptor-like 3, CKR-L3, DRY6, G-protein coupled receptor 29, GPR-CY4, GPRCY4, LARC receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell surface.
Protein: RECF_PSE14
Sequence: MSLSRVSVTGVRNLHPVTLSPSPRINILYGANGSGKTSVLEAIHLLGIARSFRSSRLLPVIQYVQPSCTVFGQVDLAQGGHSNLGVSRDRQGEFQIRIDGQNARSAAQLAEILPLQLINPDSFRLLEGAPKIRRQFLDWGVFHVEPRFMVTWQRLQKALKQRNSWLRHGTLDAASQAAWDRELCYASDEIDEFRRAYIKALKPVFEQTLSELVELEGLTLSYYRGWDKEKELSTVLASSLHRDQQMGHTQAGPQRADLRLRLGAHNAADILSRGQQKLVVCALRIAQGHLVSQVRRGQCIYLVDDLPSELDDNHRRALCRLLEELRCQVFITCVDQEFLREGWQTETPVALFHVEQGRITQTHDHRE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAT_SHIFL
Sequence: MSSRVLTPDVVGIDALVHDHQTVLAKAEGGVVAVFANNAPAFYAVTPARLAELLALEEKLARPGSDVALDDQLYQEPQAAPVAVPMGKFAMYPDWQPDADFIRLAALWGVALREPVTTEELASFIAYWQAEGKVFHHVQWQQKLARSLQIGRASNGGLPKRDVNTVSEPDSQIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity).
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: CYP11_RHIO9
Sequence: MINPRVFFDIDVDGNRIGRIVIELFADQVPKTAENFRALCTGEKGIGKVSNMPLHYKGSIFHRIIKGFMCQGGDFTHRTGKGGESIYGANFPDESFSRKHDTHGLLSMANRGPNTQTSQFFITTRPTPHLDGKHVVFGRVVSGYNVVEMMENEPVDDQDRPLHNVMIANCGELVLKLPPGALLKKASAVSDESEDEIKNRKRSRSSDDDSSSDEDSEEEERKRTKKKRSRKHSKKDKKKKKRESSNRKRSPEANRHVSRERRDISREKRDNSRERRLSRKEDDRRSPSDKRKEDRRSLSPEKRSSERRVARPVRPRLNYNDPNVEVKGRGRFKYRPTY
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase cyp11, PPIase cyp11, Cyclophilin cyp11, Rotamase cyp11.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
Protein: RUVB_SHESH
Sequence: MIEADRLIHAEPQGPEERDEQIDRAMRPKLLDEYTGQDDTRAQLKIFIKAAQNRGEALDHMLIYGPPGLGKTTLAMIVANEMGVNIKSTSGPVLEKAGDLAALLTNLEPGDVLFIDEIHRLSSVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGALTSPLRARFGIPLRLEFYNTKDLSSIVSRSANVLELPIDDEGAIELAKRSRGTPRIANRLLRRVRDFAEVKHDGEINKAVADLALDMLDIDSEGFDYMDRKLLLAIIDKFMGGPVGLDNLAAAIGEERETIEDVLEPFLIQQGFIQRTPRGRIATDRAYRHFDIIQPEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PAL_TRIV2
Sequence: MKTLSQAQSKTSSQQFSFTGNSSANVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESGEPIYGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAAMLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGASGDLVPLSYITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTSVMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPGQLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPIVDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLRYYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGNSIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYVAIALMFGVQAVDLRTYKKTGHYDARACLSPATERLYSAVRHVVGQKPTSDRPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDILPCLH
What is the function of this protein?
Catalyzes the non-oxidative deamination of L-phenylalanine to form trans-cinnamic acid, the first step in the phenylpropanoid pathway.
What are the official names of this protein?
Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRX6_HUMAN
Sequence: MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSLAQPGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVTASQEARGLRLSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAAREGRLERRECGLAAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARPRPRSPECRMIPGQPPASARRLSVPRDSACDESSCIPKAFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
What is the function of this protein?
Transcription factor.  Binds to the IBS motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor.  Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r.  Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells.
What are the official names of this protein?
Iroquois-class homeodomain protein IRX-6, Homeodomain protein IRXB3, Iroquois homeobox protein 6.
What is the protein family that this protein belongs to?
Belongs to the TALE/IRO homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRMA_CHLP8
Sequence: MQPPKTHNHIELAFEIDSDLYELYIAVLSQEGIEYFLEEDKKLLAYLPESEWNAEKEESIKTLLRETFGSAPHFTASFMADRNWNAEWEAHLQPVEISNRFLIIQHQKEYDVKPDQIVIAINPKMSFGTGYHATTRLMLRQMEELDLADKKIMDIGTGTGVLAIAARKLGNRNPILAFDNNAWAAENAVENVAENDVADIQVELLDAEEEMVANLKEGYDLILANINKNVLDRILPVIRRHAPNAQVLLSGVLVYDEPWLKKLLKRIDYTNVKTIYEDEWLSALIEPKN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADD_MYCMM
Sequence: MTDMPTLDAIRQAPKALLHDHLDGGLRPETVLDIAGQVGYDGLPSTDAGELASWFRTQSHSGSLERYLEPFSHTVAVMQTPEALYRVAYECVEDLAADAVVYAEIRFAPELHINQGLTFDEIVDAVLAGFAAGERACAGAGCPIKVRLLVTAMRHAAMSREIAELAIRFRDKGVVGFDIAGAEAGYPPSRHLDAFEYMRDNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDIEVGPDGDVKLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARSRFRVTVNTDNRLMSDTSMSQEMYRLVETFGYGWSDIQRFTINAMKSAFIAFDERLEIIDEVIKPRFAVLIG
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: SELO_MOUSE
Sequence: MASVRAAVGASLAVARTRPRCVGLALPSSAPRSAWAAAMEPTPRWLAGLRFDNRALRELPVETPPPGPEDSLATPRPVPGACFSRARPAPLRRPRLVALSEPALALLGLEASEEAEVEAEAALFFSGNALLPGTEPAAHCYCGHQFGQFAGQLGDGAAMYLGEVCTAAGERWELQLKGAGPTPFSRQADGRKVLRSSIREFLCSEAMFHLGIPTTRAGACVTSESTVMRDVFYDGNPKYEKCTVVLRIAPTFIRFGSFEIFKPPDEHTGRAGPSVGRDDIRVQLLDYVISSFYPEIQAAHTCDTDNIQRNAAFFREVTQRTARMVAEWQCVGFCHGVLNTDNMSIVGLTIDYGPFGFLDRYDPDHICNASDNAGRYTYSKQPQVCKWNLQKLAEALEPELPLALAEAILKEEFDTEFQRHYLQKMRKKLGLIRVEKEEDGTLVAKLLETMHLTGADFTNTFCVLSSFPADLSDSAEFLSRLTSQCASLEELRLAFRPQMDPRQLSMMLMLAQSNPQLFALIGTQANVTKELERVEHQSRLEQLSPSDLQRKNRDHWEAWLQEYRDRLDKEKEGVGDTAAWQAERVRVMRANNPKYVLRNYIAQKAIEAAENGDFSEVRRVLKLLESPYHSEEEATGPEAVARSTEEQSSYSNRPPLWAAELCVTUSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation).  May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein.
What are the official names of this protein?
Protein adenylyltransferase SelO, mitochondrial, Selenoprotein O, SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CIN4_YEAST
Sequence: MGLLSIIRKQKLRDKEIRCLILGLDNSGKSTIVNKLLPKDEQNNDGIMPTVGFQIHSLMIKDVTISLWDIGGQRTLRPFWDNYFDKTQAMIWCIDVSLSMRFDETLQELKELINRDENRIGYECAVIVVLNKIDLVEDKSELHRRCLLVESELKCLFKPDIRIELVKCSGVTGEGIDNLRDRLVESCHFTQ
What is the function of this protein?
Implicated in yeast microtubule function.
What are the official names of this protein?
GTP-binding protein CIN4, Chromosome instability protein 4.
Protein: ISPE_CLOK5
Sequence: MLIKAYAKINLSLDVIGKREDGYHLLKMIMQTIDLYDLLNITPIEKGIEIKCNKSYIPCDKRNLVYKAVELFASNYGIKSGVSIDIIKNIPVAAGLAGGSSDAAAVLKVMRDIYIPELEYKDLIKLGTSIGADVPYCMIGGTALCQGIGEKVTSISSFKNHILVLVKPFFGVSTAEVYKSLDISKIKIHPNTDILINAINSGSLLKVSKNMKNVLENVTLKKHPLLRKIKNELIDFGALGALMSGSGPSIFAFFDDMLKAQICYDKMKTKYKEVFITRTV
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: Y033_SIFVH
Sequence: MSEQKPEQDVNKKIEELEKKVQELQEQLEKTKQAVKTVASILDNHLKGQWTLEDVKIAITHINEMVQLLTQSGIIRPGSEGSGNWLQMMLAQQFMQQKQAQQSQDVQIEPLKKKNKKKLKKFLDEEAEEEE
What are the official names of this protein?
Uncharacterized protein 33.
Protein: XNI_SHEPA
Sequence: MNKLLIIDGMNLVRRIHAAQPNESDITGLKERVHGACRKLLKYHIPTHAAIVWDGDAISWRKTLFPDYKKGRKPMPEALANGLNDIKAYLAEHHIHSVDADSEADDVIATLATKLVNIDGEAIIVSTDKGFSQLNHPKIKLWDHFNQTYLTIEEMEKKLGIERSQLIDYLALAGDSGNKIPGVPGIGPKSAVELLRIYRSLASIYNSIDKVGAKQAKKLEAGKQMARLSYKLVQLKTDMPLSVNLKQFRIKKPDSE
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: DEOD_XENNA
Sequence: MATPHINAEMGDFADVVLMPGDPLRAQYIAETFLEDARQVNNVRGMLGFTGTYKGRRISVMGHGMGIPSCSIYAKELITEFGVKKIIRIGSCGAVSEDVKIRDVVIGMGACTDSKVNRMRFKDHDFAAIADFDLVRHAVDAAKAKNINTRVGNIFSVDLFYSPDPQMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALAICTVSDHIRTGEQTTAEERQHTFNDMIEIALESILLGDN
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: YPBD_BACSU
Sequence: MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAVIVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTHIGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVFACQIRFEHVRRDKHDEHVESREKKSPESL
What are the official names of this protein?
Uncharacterized protein YpbD.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: E4PD_ECOSM
Sequence: MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_CHLTR
Sequence: MKDPYDVVKRHYVTEKAKMLEGLSLGDGEGKKKGSFCKDPKYIFIVAGDATKPMIAEAIEAIYSAKGVKVKKVNTMCVKPQPTRIFRGRRKGRTAGFKKAIVTFVDGHSIG
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: AF1Q_RAT
Sequence: MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDSPTYKSKESNSIGKMGGQATGAERKSPEGDPLLEYSTFNFWRAPIASIRSIDLDLL
What is the function of this protein?
Cofactor for the transcription factor TCF7.  Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate.
What are the official names of this protein?
Protein AF1q.
What is the protein family that this protein belongs to?
Belongs to the MLLT11 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Continuous nuclear export is followed by degradation.
Protein: TPDB1_COMSP
Sequence: MINEIQIAAFNAAYAKTVDSDAMEQWPTFFTKDCHYRVTNVDNHAEGLAAGIVWADSQDMLTDRISALREANIYERHRYRHILGLPSIQSGDATQASASTPFMVLRIMHTGETEVFASGEYLDKFTTIDGKLRLQERIAVCDSTVTDTLMALPL
What is the function of this protein?
Component of the terephthalate 1,2-dioxygenase multicomponent enzyme system which catalyzes the dioxygenation of terephthalate (TER/TPA) to 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylic acid (DCD).  It can also use 2,5-dicarboxypyridine (PDC) and 1,4-napthalenedicarboxylic acid (NDC) as substrates, and preferentially uses NADPH which is the physiological electron donor.
What are the official names of this protein?
Terephthalate 1,2-dioxygenase, terminal oxygenase component subunit beta 1, TPADO terminal oxygenase component, TER dioxygenase system, TERDOS, Terephthalate 1,2-dioxygenase small subunit 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: FABZ_SYNS3
Sequence: MTVLASNDPPTAVLNAEQIMGLLPHRYPFALVDRVLEHVPGERAVALKNVTFNEPQFQGHFPGRPLMPGVLIVEAMAQVGGLIVTQMPDLPKGLFVFAGIDGVRFRRPVVPGDQLRITCELLSLKRKRFGKVKAEATVDGQLVCSGELMFSLVD
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFC4A_RAT
Sequence: MASPGPPGAGQGQEEEERAGVSAGHQAEVLQQAQELFVLCDKDAKGFITRQDLQGLQSDLPLTPEQLEAVFESLDQAHTGFLTAREFCLGLGKFVGVESVPGRAPLRTPEETFESGTGGSLEEEDDVETFYTSLEKLGVARVLGEQWAVRTLWVGLQRERPELLGSLEEILMRASACLEAAARERDGLEQALRRRESEHEREVRGLYEELEQQLREQRQRRQSQNPPREEERGHLELELQTREQELERAALRQRELEQQLQARAAEQLEVQAQHIQLQRAYEALRAQLDQAQEQLIRLEGEAQGRQEQTQRDVVAVSRNMQKEKLSLLRQLELLRELNLRLRDERDACETKLLGSSHRKALAIAHKPGPIYCCCCCGWARPPRRGSGHLPSAR
What is the function of this protein?
Plays a role in store-operated Ca(2+) entry (SOCE).
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 4A, Calcium release-activated channel regulator 2B.
What is the protein family that this protein belongs to?
Belongs to the EFCAB4 family.
Protein: NCAP_I37A0
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMIGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRIDGKWMRELILYDKEEIRRIWRQANNGEYATAGLTHIMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGHDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGKRVVPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATVMAAFIGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATSPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: TSAD_STRP3
Sequence: MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITTCFEDALQEAGISASDLSAVAVTYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETRDDAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNAKQKGDELILEDLCASFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCGDNAGMIALAAAIEYDKQHFANMSLNAKPSLAFDQFPDSFVIN
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MO2R3_MOUSE
Sequence: MHALGRTLALMLLIFITILVPESSCSVKGREEIPPDDSFPFSDDNIFPDGVGVTMEIEIITPVSVQIGIKAQLFCHPSPSKEATLRIWEITPRDWPSCRLPYRAELQQISKKICTERGTTRVPAHHQSSDLPIKSMALKHDGHYSCRIETTDGIFQERHSIQVPGENRTVVCEAIASKPAMQILWTPDEDCVTKSKSHNDTMIVRSKCHREKNNGHSVFCFISHLTDNWILSMEQNRGTTSILPSLLSILYVKLAVTVLIVGFAFFQKRNYFSSRDLVFMKERRSKRSVWQREALG
What is the function of this protein?
According to PubMed:15187158 isoform 4 is a receptor for the CD200 cell surface glycoprotein.  According to PubMed:16081818 isoform 4 is not a receptor for the CD200/OX2 cell surface glycoprotein.  Isoform 1, isoform 2 and isoform 3 are involved in the recruitment or surface expression of the TYROBP receptor.  Isoform 6, isoform 7 and isoform 8 are not involved in the recruitment or surface expression of the TYROBP receptor.
What are the official names of this protein?
Cell surface glycoprotein CD200 receptor 3, CD200 cell surface glycoprotein receptor-like 3, CD200 receptor-like 3, CD200 cell surface glycoprotein receptor-like b, CD200RLb, Cell surface glycoprotein OX2 receptor 3.
What is the protein family that this protein belongs to?
Belongs to the CD200R family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.