PharMolix/UniProtQA huggingface dataset:
Protein: RS12_HALMA
Sequence: MANGKYAARKLKKDRQKHRWSDTDYARRERGLGKKSDPLEGAPQGRGIVLEKVGIEAKQPNSAIRKCVRVQLIKNGKQVTAFCPGDGAISFIDEHDEVTIAGIGGAKGRAMGDLSGVNYKVEKVNGVSLIELVRGNAEKPVR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: GPAT3_MOUSE
Sequence: MEGADLAVKLLSTWLTLVGGLILLPSAFGLSLGISEIYMKILVKTLEWATLRIQKGAPKESALKNSASVGIIQRDESPMEKGLSGLRGRDFELSDVFYFSKKGLEAIVEDEVTQRFSSEELVSWNLLTRTNVNFQYISPRLTMVWVLGVLVRYCFLLPLRVTLAFIGISLLIIGTTLVGQLPDSSLKNWLSELVHLTCCRICVRSLSGTIHYHNKQYRPQKGGICVANHTSPIDVLILATDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERSEIKDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIYPVAIKYNPQFGDAFWNSSKYNLVSYLLRIMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAIAVQGGLTELPWDGGLKRAKVKDTFKEEQQKNYSKMIVGNGSPNLARD
What is the function of this protein?
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135).  Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).  Protects cells against lipotoxicity (By similarity).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 3, GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, AGPAT 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, 1-AGP acyltransferase 9, 1-AGPAT 9, Acyl-CoA:glycerol-3-phosphate acyltransferase 3, mGPAT3, Lysophosphatidic acid acyltransferase theta, LPAAT-theta.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DPFGD_GIBZE
Sequence: MAQSVPPASSHGQLTVGEVGTSVNSVPYARHEEIIRAPLTYLLNLPGKDVRSKMIAAFNQWLKIPEDKLDVIKRIIMLLHNASLLLDDIQDSSKLRRGLPVSHSIFGIAQTINAANYAFFLAQQELPKLGDARAFEIFTEELLHLHRGQGMDIYWRDASICPTEEEYFTMVSNKTGGLFRLAVKLMQLASESDKDYVPLVNVLGVIFQIRDDYLNLQSGNYAKNKGFGEDLTEGKFSFPIIHSIRSNPANIQLSSILKQRTTDIDVKLFAVGYIESTGSFEHCRRKLVELTAEARAIMENIADGRSEDLESYACILLSKLILYNRLTYKVPAAQVIHGASGGYSTAPKPRILAQQIATVRAPHLQYAT
What is the function of this protein?
Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable).  The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350).  The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350).  Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).
What are the official names of this protein?
Geranylgeranyl pyrophosphate synthase dpfgD, GGPP synthase, GGPPSase, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Diterpenoid pyrone biosynthesis cluster protein D, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: LYSC_TRAFR
Sequence: MRALIILGLVLLSVTVQGKIFERCELARTLKKLGLDGYKGVSLANWVCLAKWESGYNTEATNYNPGDESTDYGIFQINSRYWCNNGKTPGAVDACHISCSALLQNNIADAVACAKRVVSDPQGIRAWVAWRNHCQNKDVSQYVKGCGV
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.  Also plays a role in digestion in this species.
What are the official names of this protein?
Lysozyme C, 1,4-beta-N-acetylmuramidase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YJQ5_SCHPO
Sequence: MSGFYKGVAAEQETLFTTADKKLMRSTKFPASYDTKVDMKKVNIEVLKPWIATRLNELIGFEDEVVINFVYGMLEEAVEASKTSDSQNESTLDPRKVQLNLTGFLESNATAFTEELWSLIISASQNQYGIPEKFILEKKEEISKLKDRTEASKEESKTVTDHSNRRESRRESTYYDSRERNGKRTSRSTLDRKRFHDASDTERNRYGRSPSPHSRFSEKPRGERYDIRSYSRSHKERYEDRYRPTRRRERHYRTRDDEGFDEFGRSRDGRWRESRTSYREKHRYDRDALSSESDSGTQKHD
What are the official names of this protein?
PWI domain-containing protein C825.05c.
What are the subcellular locations of this protein?
Nucleus.
Protein: MORC4_HUMAN
Sequence: MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMIITEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQYDILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIAKSLANVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRGEGVGVIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFETSTVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTDEDLCLSKAKKQEQTVEEKKKMPMENENHQVFSNPPKILTVQEMAGLNNKTIGYEGIHSPSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKWILGEEPVEKRRRLQNEMTTPSLDYSMPAPYRRVEAPVAYPEGENSHDKSSSERSTPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGSLLPEELEDQMPRLVAEESNRGSTTINKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVASAAIPAAAIGEKARGYEESEGHNTPKLKNQRELEELKRTTEKLERVLAERNLFQQKVEELEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQILKAELERTKEEKQELKEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVSYLLTSVLPHLELREIGYDSEQVDGILYTVLEANHILD
What is the function of this protein?
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034).  The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034).
What are the official names of this protein?
MORC family CW-type zinc finger protein 4, Zinc finger CW-type coiled-coil domain protein 2, Zinc finger CW-type domain protein 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRE_XANOM
Sequence: MTDHRTRFLQLALGADALRFGQFTLKSGRLSPYFFNAGRFDSGTKTAQLAQCYADAIDAAGVDFDLLFGPAYKGIPLATALACAYAGRGRDLPLAFNRKEAKDHGEGGTLIGAPLAGHKVLIVDDVITAGTAIREALGIIRAAGGVPSGIVVALDRQEIASEQDRRSAAQAVATEAGIPVIAVANLSDLLAFAAENADLVDFREPLLAYRGRYGTDTTG
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: GATC_DROPS
Sequence: MLRVLSRRFYCKIAAKTNFKTAKLDFKELRYATKVPQTPVDTVFPETNANRVEIDAKTIQLLERLSLVNLDSEQALATLNSSIQFADKIAHINTENVRPLYTVLENQQLQLRNDEVKEGDCRVELLRNAKVTDEDYYVSPPGNIPLEQ
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial, Glu-AdT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NCBP2_ARATH
Sequence: MASLFKEQAKLSAYRDRRFSGTQEEFDEALRASTTVYIGNVSFYTTEEQLYELFSRAGEIKKIIMGLDKNTKTPCGFCFVLFYSREDTEDAVKYISGTILDDRPIRVDFDWGFQEGRQWGRGRSGGQVRDEYRTDYDPARGGYGKLVQKELEAQRQLVDYGTGSLGAYPQAAPTNYGNGRRGGGNYGQGGQNRHGRGDYHRKRQRDDDRYGRDNSRRNTDHESRRDTDSDMRPEKNPRFRESGDSDDDGEDDRKRRS
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs).  The CBC complex is involved in miRNA-mediated RNA interference and is required for primary miRNA processing.  In the CBC complex, CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ABH1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.  CBP20 also plays a role in stabilization of ABH1/CBP80 and ABH1/CBP80 localization to the nucleus.  Involved in flowering regulation via its interaction with FRIGIDA.
What are the official names of this protein?
Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, AtCBP20.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly nuclear.
Protein: UCP1_DICGR
Sequence: MVSLTTSEVHPTMGVKTFSAGISACLADIITFPLDTAKVRLQIQGEGQTSSTIRYKGVLGTITTLAKTEGWPKLYSGLPAGIQRQISFASLRIGLYDTVQEYFSSGKETPPTLGNRISAGLMTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTESFSTLWKGTTPNLMRNVIINRTELVTYDLMKGALVNNQILADDVPCHLLSALVAGFCTTFLASPADVVKTRFINSLPGQYPSVPSCAMTMLTKEGPTAFFKGFVPSFLRLASWNVIMFVCFEQLKKELMKSRQTMDCTT
What is the function of this protein?
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance.  Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane.  However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs.  Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP.  Regulates the production of reactive oxygen species/ROS by mitochondria.
What are the official names of this protein?
Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL8_MAMBR
Sequence: MGRVIRAQRKGAGSVFVSHTKKRKGAPKLRSLDYAERHGYIKGVVKDIIHDPGRGAPLAVVHFRDPYKFKTRKELFIAPEGLYTGQFVYCGKKATLEVGNVMPVGAMPEGTIVCNLEEKMGDRGRLARASGNFATVIGHNPDAKRTRVKLPSGAKKVLPSSNRGMVGIVAGGGRIDKPILKAGRAYHKYKVKRNCWPYVRGVAMNPVEHPHGGGNHQHIGKASTVKRGTSAGRKVGLIAARRTGRIRGGKTDTKKET
What are the official names of this protein?
60S ribosomal protein L8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRE2_THEPA
Sequence: MREVLVVSESVELAEEYYLSFNKFSSGSTSLLGQVTKASFFSSLASSGTKSLNTKSFGLKSLSLKSLNTKSSGLKSLNTKSSGLKSLGLKNEFDYLTFEQVKSSGLEDERYELILVVCDDTDDFYGEKGLANLTLFHNSLLPNGKFVLAVPLNSPHEEEMRKELMYSGLVDVASCAYYLTKFITGVRPNWKAKGDRKSSSIHAAPIDGYISKAPDYESCSTKPRACANCTCGRAERENLNSTDSNANSTDFNANSTDFNGVDLTTNSKDVSGVDLVVDVDAPTSSCGNCYLGDAFRCDSCPYKGLPAFKPGEKVLLE
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog, Fe-S cluster assembly protein DRE2 homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: GLPK_HALSA
Sequence: MTDAYVGAIDQGTTGTRFIVFDQHGDVVANTYEKHEQHYPEPGWVEHDPLEIWENTKSVVTAGLSAAGLDADDLAAIGITNQRETTVVWDAASGRPIHNALVWQDRRTTSRVESLEENGKIERIREKTGLEADAYFSATKTEWLLDEAEPLKLSSARASSLRDRARDGELLMGTIDSWLIYNLTGEHITDVSNASRTMLYNITDLEWDDWLLEEFDIPREMLPEVRPSSDEAVYGHTDPDGFLGAAVPVTAALGDQQAALFGQTCFDAGDAKNTYGTGSFYLMNTGEDAVSSEHGLLTTIGFQLSGEPVQYALEGSIFVTGAAIEWLEDVDLINNAAQTAELASSVDTTDGVYMVPAFTGLGAPHWDGRARGTLVGMTRGTRKAHIVRATLESIAYQTRDIAAAMEADSGVSTTTLRVDGGAVKNNFLCQLQSDIIQTDLARPEVDETTALGAAYAAGLAVGYWDSLDDLRENWRVDRSFEPEMDPSEADSKYGRWEDAVDRSLAWATED
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RSMH_CAMJR
Sequence: MEIPHIPVLLNEVQEIFKNLKTGYFLDCTLGFGGHSEALLKNHPDLKFIACDQDQQALEFSKKRLKDFRNRITFMQSNFSEVLEKISHKEELRGILADIGVSSFQLDNNERGFSVNSDFLDMRMNQNSKISAYEIINTYTKEQLTSIFKDYGELHDAHFIAEKICLERSKNPIKSAKELYQIIGKGKQNHRKISKATLAFQAIRIEVNQELKVLKDFLGHLENLKPKNCILAIISFHSLEDRIVKQFFKKWSKNCICNEKIMRCECGNNHSLGQIITKKAISASKEELLKNSRSSCAKMRAFYFNNLDNK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_AERPE
Sequence: MLGPPSREKWSSDFPRWFDWVIETAEVYDYGRYPVKGMGVWMPYGFQIRRRVLEVVRGLLDSTGHEEVLFPLLIPEHLLRRESEHIRGFEGEVYWVTHGGREELDVKLALRPTSETSITYMETFWIKSYRQLPKKYYQVVSIFRYETKATRPMIRLREVTTFKEAHTVHESFEDAERQVLEAIEVYKAIFDRLLIPYVISKRPEWDKFAGALYTIAFDTIMPDGRALQIGTVHHLGQSFTRAFDFRIQMRDERLDHPWQTSYGVSDRVVASLIAVHGDDRGLVIPPSVAPIQVVVIPITPGDEEKRGKVLTYTAKAAEALEKAGLRVHVDDREWERPGAKFYYWEAKGVPIRVEIGLREAEQDTLTIARRDTLEKTEVPLGEAGNRIRELMAQIESSMRERAKSFFGERLLRTESLEEARDWVEGRRGIAEIPWCGRESCGLEMEERVNGKVLGTPWPEEPVEEGKRCPLCGRPAVAWIRLAKTY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENY2_DROPS
Sequence: MTIFNAVDKFTMMSGDRVKIKDLLSSRLTECGWRDEVRLLCRSILQEKGAISSFTVEQLVTEVTPRARSLVPDAVKKELLIKIRTIFDENEADDIDPEEA
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes.  The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Involved in transcription elongation by recruiting the THO complex onto nascent mRNA.  The AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
What are the official names of this protein?
Enhancer of yellow 2 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm.
Protein: SUCC_MYCSS
Sequence: MDLFEYQAKELFAKHNVPTTPGRVTDTAEDAKAIAEEIGKPVMVKAQVKVGGRGKAGGVKYAATADDAFTHAQNILGLDIKGHVVKKLLVAEASDIAEEYYISFLLDRANRTYLAMCSVEGGVEIEEVAATKPDRLARIPVDATKGVDEAFAREIAEKGHLPAEVLDAAAVTIAKLWEVFVGEDATLVEVNPLVRTPDDQILALDGKVTLDANADFRHPEHAEFEDRDATDPLELKAKENDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHNGVKPANFLDIGGGASAEVMANGLDVILNDSQVKSVFVNVFGGITACDAVANGIVKALEILGEEANKPLVVRLDGNRVEEGRKILADANHPLVVLAQTMDEGADKAAELANK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: PROA_BRUC2
Sequence: MLVKADMTKDIAQVMAEVGRKAKAAAAPLSIATSEQKNKALNAAADAILEARADILEANRLDLANAEKNGMAASFVDRLTLNEARIDAIAEDIRAIATLPDPVGEVIAEWDRPNGLHIERVRTPLGVIGVIYESRPNVTADAGALCLKAGNAVILRGGSDSAHSSAAIHKALVKGLEAANLPADAIQIVPVTDRAAVGEMLKGLGGAIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHLYIDKSADLDMARRIALDAKMRRTGICGAAETLLVDRAVASTHLAPILGDLAAGGCEIRGSAEVLALYPAAKPATEEDWSTEYLDAIISVALVDGISGAIDHINRYSSHHTEAIVAEDAQTVARFFNEIDSAILLHNASTQFADGGEFGMGAEIGIATGKMHARGPVGVEQLTSFKYRVRGSGQVRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBID_SYNSC
Sequence: MSGSIAPSSPGLTLPVWVAAAAKAALQVLLDEPFNAEQQLNQGSDRPSLQVPVCSAAPLSDGQALGISRCDPGPGLDLTRDLEVWVRVAWIATPQPVLELQPGEGVGRLGPEGDICLSGFARELLERNLLPLLPAGRGLMVQPILPRGRSLAQRTSNAAFGVVDGLALIGTQAEVQRSAAPDQLQEVLAELEARAADPAFQGRLVLVIGENGLDLARQQGLGPVLKVGNWVGPVLVAAAEAGVRDLLLLGYHGKLIKLAGGIFHTHHHLADGRLEVLVALGLDAGLSTAELLQCRGAASVEEAFQALDPDQARALGQHLAAIVEQRSHSYLARYGAWSMRIGAALFDRSRTLRWWGPEAEKRFFTLRD
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: UXUA_ECOL5
Sequence: MEQTWRWYGPNDPVSLADVRQAGATGVVTALHHIPNGEVWSVEEILKRKAIVEDAGLVWSVVESVPIHEDIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRPGAEADYTEEEIAQAAERFATMSDEDKARLTRNIIAGLPGAEEGYTLDQFRKHLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVDTVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTMREDNPKTFHEAAHLNGDVDMYEVVKAIVEEEHRRKAEGKEDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQRAFFSR
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: ARALA_ARAEL
Sequence: ANFPTVSLNTVGITRQIPQDFMNAV
What is the function of this protein?
Toxic type II ribosome-inactivating protein (RIP).  Induces apoptosis.  Has cytotoxic activity against several human cancer cell lines.  Is less cytotoxic to normal human cells.
What are the official names of this protein?
Aralin A chain, rRNA N-glycosidase.
What is the protein family that this protein belongs to?
Belongs to the ribosome-inactivating protein family. Type 2 RIP subfamily.
Protein: RL21_TOLAT
Sequence: MYAVILSGGKQHRVAEGQVLRLEKLEAATGAAVEFDKVLMVTNGDDVKVGAPYVAGGKVVAEVVAHGRGDKVHIVKFRRRKHHRKQAGHRQWFTEVKITAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: UREE1_BRUSU
Sequence: MFRAIAIIRAHEVIDAVPASHIVLERDERHLRRKAITLENGEKILADFAEPVVLEHGDRLVLDDGREIEIRAASEELYEIRGRDPRHIAELAWHIGNRHLAAQIETDRIFILRDHVIRVMLEGLGATVTDVVAIFSPLRGAYSGGHQHHHGHDHDHHHPDHE
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE 1.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYMM_YEAST
Sequence: MQCRSIVHRLYSKVSHVTTPIFYPNAKPHLGHLYSSLLSDVYHRWQLFKGNLSFFTTGTDEHGLKIQCASESNGFDQPKKFVDKLYPEFVQLDKIYGINYTRFIRTTDPDHIENVMKLWELCLKNGYIYMGEHKGWYSISDETFYPESKVIKDPKNDGKYLNTESKNEVVYQSETNYFFRLSLFNKKIVDHIRKNPDFIFPASKRDQILKELETGGTLPDLSISRPSARLKWGIPTPNDPSQKVYVWFDALCNYLSSIGGIPSILSNATEVVSRHYSDKSNVKGQLLIPYPKEVQRNTIHVIGKDIAKFHTVYWPSFLLAAGLPLPRQIVVHGHWLCNGMKMSKSLGNVVDPIDMARYYGADIVRWFLLENSKLEEDGDFQEAKLYETRELLVSKWGNLINRCCGSKFNIERAVMKFSDKANFQFQEIFQNEPIVSERIENLAKLLNKSQEVFDEKIAIFQYPQLLRHVWSIINDANTLVQNSKPWERELDQQDNIIFLAMETSRILSILCQSIIPSLSQSFLDRIDVSKEKRTINYARLGSDKTYGKQSNKKGREVPLKKIPFRLQEEQTNMRS
What is the function of this protein?
Catalyzes the attachment of methionine to tRNA(Met) in the mitochondrion.
What are the official names of this protein?
Methionine--tRNA ligase, mitochondrial, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.