PharMolix/UniProtQA huggingface dataset:
Protein: TERT_HUMAN
Sequence: MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
What is the function of this protein?
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes.  Active in progenitor and cancer cells.  Inactive, or very low activity, in normal somatic cells.  Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.  Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'.  The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension.  More active on substrates containing 2 or 3 telomeric repeats.  Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers.  Modulates Wnt signaling.  Plays important roles in aging and antiapoptosis.
What are the official names of this protein?
Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2.
What is the protein family that this protein belongs to?
Belongs to the reverse transcriptase family. Telomerase subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-707. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT.
Protein: ACUK_AJECG
Sequence: MTASTQNGSPTPPPAAPTATNQESKNMTANPADASESQSPANEKGSGTAESGQKHTSTAANAKDPLRPRRKKAKRACFACQRAHLTCGDERPCQRCIKRGLQDACHDGVRKKAKYLHDAPNEALMPGIRRNFYNQANATRTNANQQQNGPNSNSNKDSRQNVAANFYSPQSASNFDVYTQAKSQQGQGHIPPTVMQDTSINPSAFQAPSPTSTPNFDLSSNPPNRNLSSAMTQTPSSASNQTQDPFGAAFFDPSHPALFNFDIASMNFGNRYGALEFGMLGHMATGAGDTPPSDSATQRGSIGRSSGTFTAQNFGDSTNTQSPFLFGDPVLNDWNPSGQSQTNPRNNNIYNQNTVAGQMGEQHPNAFAIESAPMNFASPGSTESPQMTTMNQFDEANAKFSSRTALMHQTNPHQPPPISTPGLKHQGFQVGVKRRYRSPSSIYESVKEPYSYTSGFHNLTAFIQRRFSPQKTLQIAKALASIRPSFIATTKTLNQDDLIFMEKCFQRTLWEYEDFINACGTPTIVCRRTGEIAAVGKEFSILTGWKKEVLLGKEPNLNVNTGGSSPRGSGTFTPRNGNGVDPHSGMSAAGGGGGRTQPVFLAELLDDDSVIEFYEDFAKLAFGDSRGSVMTTCKLLKYKTKEDSAALFQGKEAQQGGSDGKGGGGGGDVAATAATTSTSTSNGANSSGHANANRNNTNPKNSSPPSSSSAAAAGPLHGAQLSPKQTWGKRGIAGEAGMNQLGFRDGKVECSYCWTVKRDVFDIPMLIVMNFLPCI
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis HCBG_00867.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS12_STRM5
Sequence: MATINQLVRKPRQATTYKSASPALDKCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTNQEEVISYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGSLDAAGVAKRRQARSKYGAKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SPIN3_PONAB
Sequence: MKTPFGKAAAGQRSRTGAGHGSVSVTMIKRKAAHKKHRSRPTSQPRRNIVGCRIQHGWKDGDEPLTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELHRDERVSSLEVLPNRVASSRISDTHLAEIMVGKAVEHIFETEEGSKNEWRGMVLAQAPVMNTWFYITYEKDPVLYMYQLLDDYKDGDLRILQDSNDSPLAEREPGEVIDSLVGKQVEYAKDDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
What is the function of this protein?
Exhibits H3K4me3-binding activity.
What are the official names of this protein?
Spindlin-3, Spindlin-like protein 3, SPIN-3.
What is the protein family that this protein belongs to?
Belongs to the SPIN/STSY family.
Protein: RS16_PROM3
Sequence: MIKLRLKRFGKKREASFRLVACNSTSRRDGRPLQELGFYNPRTKETRLDTEALRLRLSQGAQPTDAVRSLLEKGGLIEKTVRPAEVVGKAKQAEARKAGAKNVAKQAAEAKAEETPADNTEA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: HOKD_SHIFL
Sequence: MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system (By similarity).  When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration (By similarity).  Its toxic effect is probably neutralized by an antisense antitoxin Sok RNA (By similarity).
What are the official names of this protein?
Protein HokD, Protein RelF.
What is the protein family that this protein belongs to?
Belongs to the Hok/Gef family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LYSR_ECOLI
Sequence: MAAVNLRHIEIFHAVMTAGSLTEAAHLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPQLLQPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHTPAGTERTELLSLDEVCVLPPGHPLAVKKVLTPDDFQGENYISLSRTDSYRQLLDQLFTEHQVKRRMIVETHSAASVCAMVRAGVGISVVNPLTALDYAASGLVVRRFSIAVPFTVSLIRPLHRPSSALVQAFSGHLQAGLPKLVTSLDAILSSATTA
What is the function of this protein?
This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase.  LysR is also a negative regulator of its own expression.
What are the official names of this protein?
Transcriptional activator protein LysR.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUAC_ARATH
Sequence: MALTVAKSALEAIREKGLGGFMRMIREEGFMRCLPDGNLLQTKIHNIGATLVGVDKFGNKYYQKLGDTQYGRHRWVEYASKDRYNASQVPAEWHGWLHFITDHTGDELLSLKPKRYGLEHKENFSGEGDAYIYHSKGHTLNPGQKNWTRYQSWVPTKTQ
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA12 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ATPA2_HAHCH
Sequence: MQQLNPSEISEIIKKRIEKLDISSEAKTEGTIVSVSDGIVLIHGLADVMYGEMIEFEGGVYGLALNLERDSVGAVVLGDYKDLAEGQKVRVTGRILEVPVGEQLLGRVVDGLGNPIDGKGALETTLTEPVEKVAPGVIARKSVGQPMQTGYKSVDTMVPIGRGQRELVIGDRQTGKTALAIDAIINQKGTGIKCIYVAIGQKQSSIANVVRKLEEHGAMDHTIVVAAGAADPASMQFLAPYSGCTMGEYFRDRGEDALIIYDDLTKQAWAYRQISLLLRRPPGREAYPGDVFYLHSRLLERASRVNEEYVEKYTNGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETSLFNAGIRPAMNAGISVSRVGGAAQTKIMKKLGGGIRLALAQYRELAAFAQFASDLDEATRKQLEHGQRVTELMKQKQFAPMTVAEMGLVLFAANEGFLDDVDAKKVVPFEAALLSYAKSEFGDLLAKINEAGDYNDEIAAGLKSCIEKFKSTQTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 2, ATP synthase F1 sector subunit alpha 2, F-ATPase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RDGC_PHOLL
Sequence: MLWFKNLMIYRLNRETSLSADELEKQLSPLAFTPCGSQDMAKTGWVPPMGSHSDAFTHVANNQILICARKEEKMLPSPVIKQALQAKIEKLEGEQHRKLKKTEKDSLKDEILHTLLPRAFSRFSQTYIWIDIANNLIVIDAASAKRAEDNLALLRKSLGSLPVVPLTFKNPIELTLTEWVRSGALPTGFALMDEAELKAILEEGGVIRCKKQDLVSDEIATHIEAGKCVTKLALDWEERIQFMLSDDGTFKRIKFSDTLREQNDDIDREDFAQRFDADFILMTGELSALINSTIEALGGEAEK
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RNPS1_MACFA
Sequence: MDLSGVKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASSGSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRRRSRSKSKPPKRDEKERKRRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMHPHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFSPPRRMLPPPPMWRRSPPRMRRRSRSPRRRSPVRRRSRSPGRRRHRSRSSSNSSR
What is the function of this protein?
Part of pre- and post-splicing multiprotein mRNP complexes.  Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets.  The ASAP complex can inhibit RNA processing during in vitro splicing reactions.  The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis.  Enhances the formation of the ATP-dependent A complex of the spliceosome.  Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner.  Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.  Participates in mRNA 3'-end cleavage.  Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Also mediates increase of mRNA abundance and translational efficiency.  Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity).
What are the official names of this protein?
RNA-binding protein with serine-rich domain 1.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (By similarity).
Protein: RS10_BLOPB
Sequence: MQNQRIRIRLKAFDHRLIDKSTVEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHKRLIDIVEPTDKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: CVC2_HHV2H
Sequence: MDPYYPFDALDVWEHRRFIVADSRSFITPEFPRDFWMLPVFNIPRETAAERAAVLQAQRTAAAAALENAALQAAELPVDIERRIRPIEQQVHHIADALEALETAAAAAEEADAARDAEARGEGAADGAAPSPTAGPAAAEMEVQIVRNDPPLRYDTNLPVDLLHMVYAGRGAAGSSGVVFGTWYRTIQERTIADFPLTTRSADFRDGRMSKTFMTALVLSLQSCGRLYVGQRHYSAFECAVLCLYLLYRTTHESSPDRDRAPVAFGDLLARLPRYLARLAAVIGDESGRPQYRYRDDKLPKAQFAAAGGRYEHGALATHVVIATLVRHGVLPAAPGDVPRDTSTRVNPDDVAHRDDVNRAAAAFLARGHNLFLWEDQTLLRATANTITALAVLRRLLANGNVYADRLDNRLQLGMLIPGAVPAEAIARGASGLDSGAIKSGDNNLEALCVNYVLPLYQADPTVELTQLFPGLAALCLDAQAGRPLASTRRVVDMSSGARQAALVRLTALELINRTRTNTTPVGEIINAHDALGIQYEQGPGLLAQQARIGLASNTKRFATFNVGSDYDLLYFLCLGFIPQYLSVA
What is the function of this protein?
Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes.  Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.
What are the official names of this protein?
Capsid vertex component 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae CVC2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: SYV_GLUOX
Sequence: MLEKSFVPADHENALYDAWEKSGAFRAHPDQPGEPFSIMFPPPNVTGTLHLGHSLNFVLQDMLIRWKRQEGFNVLWQPGTDHAGIATQMVVERALDKEGTSRTALGREGFLERVWDWKQEYGGTIVKQLRKLGASADWERERFTMDDGLSRAVRKVFVTLYNEGLIYRDRRLVNWDPKFRSAISDLEVENHETKGSMWYIRYPLEDGRTITVATTRPETMLGDVAVAVHPEDERYADMIGKTVILPLTGRRIPVVADLHSDPEKGTGAVKITPAHDFNDFEVGKRHDLPAPTVLDETACLWIEEIRPELRDVEGLASVAFVETLNGLSREEGRKQVVAELERLEWLEKIEPHKLQVPHAERGGAIVEPRLTLQWYCDAKTLSGPAVEAVESGKIAFEPRQWENTFHAWMRDIQPWCISRQLWWGHRIPAWYGADGKVYVAENEQDAQVQAGEGVSLTQDEDVLDTWFSSALWPFTTLGWPDRTEELARYYPTSVLVTGFDIIFFWVARMMMMGLHFMDDVPFRTVLIHGLVRDEKGQKMSKSKGNGLDPLDLVAEFGADATRLAICAGTGPGRDIKLGRKRVEEHRAFVTKLWNAARFLEMNGAKPTEDFDPASVKSALGRWILTEANDAITEAGRALSVYRFDEYASCCYRFVWSRFCDWFVEFSKPVFAAENEETAELRAVSAHVLGLILRLMQPVIPFVTATLWQELGYPGKFEEIRWPEIMTVTRADEARAELDWVIRLIGDVRTVRSEMNIPPSQKAPLLLRDAAPENLERAKTWAEAIGRMARVSDVGVVGEDAPRNAAQLVLDEATVFIPLEGLIDLDAERARLAKEITRIEGEILKVTRKLDNADFVARAKPEVVEENHDRLATFQSDLERLKAALGRLA
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_HAEIE
Sequence: MSAFQPTIKRRESTKIYVGNVPIGGDAPIAVQSMTNTRTTDVEATVAQIKSLERVGADIVRVSVPTMDAAEAFKQIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGREDRIRAVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPEALLESALRHVEILDRLNFNQFKVSVKASDVFLAVEAYRLLAKAIKQPLHLGITEAGGARAGAVKSAVGLGMLLAEGIGDTLRVSLAADPIEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSDLGVTGGNKKAVIILTANVKKSVLITKI
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: Y1135_ARATH
Sequence: MRLHESLSPIVHVLSLSCFFLSVSLAHERALFSGTLNDSETIVSSFRTFRFGFFSPVNSTNRYAGIWYNSIPVQTVIWVANKDTPINDSSGVISISEDGNLVVTDGQRRVLWSTNVSTRASANSTVAELLESGNLVLKDANTDAYLWESFKYPTDSWLPNMLVGTNARTGGGNITITSWTNPSDPSPGSYTAALVLAPYPELFIFNNNDNNATVWRSGPWNGLMFNGLPDVYPGLFLYRFKVNDDTNGSATMSYANDSTLRHLYLDYRGFAIRRDWSEARRNWTLGSQVPATECDIYSRCGQYTTCNPRKNPHCSCIKGFRPRNLIEWNNGNWSGGCIRKLPLQCERQNNKGSADRFLKLQRMKMPDFARRSEASEPECFMTCLQSCSCIAFAHGLGYGCMIWNRSLVDSQVLSASGMDLSIRLAHSEFKTQDRRPILIGTSLAGGIFVVATCVLLARRIVMKKRAKKKGTDAEQIFKRVEALAGGSREKLKELPLFEFQVLATATDNFSLSNKLGQGGFGPVYKGMLLEGQEIAVKRLSQASGQGLEELVTEVVVISKLQHRNLVKLFGCCIAGEERMLVYEFMPKKSLDFYIFDPREAKLLDWNTRFEIINGICRGLLYLHRDSRLRIIHRDLKASNILLDENLIPKISDFGLARIFPGNEDEANTRRVVGTYGYMAPEYAMGGLFSEKSDVFSLGVILLEIISGRRNSHSTLLAHVWSIWNEGEINGMVDPEIFDQLFEKEIRKCVHIALLCVQDAANDRPSVSTVCMMLSSEVADIPEPKQPAFMPRNVGLEAEFSESIALKASINNVTITDVSGR
What are the official names of this protein?
G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: YDR14_YEAST
Sequence: MKTFFLIEAGRALQIVAFRPAITTVLFQRFSVSFSCSYFTCCTSQLLRENWLFKFLTAFDHVIRASNDLSTMRFMIMYIYVYIYIYTVLRKRLSCYMLIL
What is the function of this protein?
May be involved in growth at elevated pH and presence of calcium.
What are the official names of this protein?
Uncharacterized protein YDR114C.
Protein: RS11_STAA3
Sequence: MARKQVSRKRRVKKNIENGVAHIRSTFNNTIVTITDEFGNALSWSSAGALGFKGSKKSTPFAAQMASETASKSAMEHGLKTVEVTVKGPGPGRESAIRALQSAGLEVTAIRDVTPVPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: IMQE_ASPFN
Sequence: MTMLSDLPKIPTLDWADFAEGDTDQRLKLAQGLVQGFKRFGFVKLVNHGLSDELIQQLFAEVKRFYRLPDELKQKAAHPPGPNPQRGWSGIGVESTSKLYGEQTERPSGKLKDAKVGTDFSSSKLSRELTHMKEHYDIGPPTDTQFPTRWPDEQDIPGWRAFMESYYARGQSFCLDLMEALEIGLELPKNTLRSMCIPDGSELRLLHYPEIPAAELRTGDTARIWPHTDFGLITLLFQDGVGGLEVEDPLQQGHYIEVAREQPYEMIVNVSATFERWMNGVIKAAVHRVNITPEGKHVEDAVVPERWSAAYFFKAHKMAHAGPLPAFVTPERPALYDNITALEFQKRRTDLVYTGQQLKVEEAA
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination (PubMed:29182847).  ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors (PubMed:29182847).  N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline (PubMed:29182847).  Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation (PubMed:29182847).  The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH (PubMed:29182847).  Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins (PubMed:29182847).
What are the official names of this protein?
2-oxoglutarate-dependent dioxygenase imqE, Imizoquin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: SYV_PSE14
Sequence: MDKTYQPHAIETSWYQTWESENYFAPQGVGDSYTIMIPPPNVTGSLHMGHGFNNAIMDALIRFRRMQGRNTLWQPGTDHAGIATQMLVERRLEAQGISRHELGREKFLDKIWEWKAESGGNISRQIRRLGSSVDWSRERFTMDDGLSDAVKEAFVRLHEDGLIYRGKRLVNWDTKLHTAISDLEVENHDEKGHLWNLRYPLADGAKTAEGLDYLIVATTRPETMLGDAAVAVNPQDERYKALIGKFVELPLVGRRIPIIADDYCDPEFGTGCVKITPAHDFNDYEVGKRHNLPLLNIFDKNANVLAAAQVFNLDGTLNESVDGSLPAAYAGLDRFEARKQIVAAFDAAGLLVSVDDHALKVPKGDRSGTIIEPWLTDQWYVSTKPLAEPAIAAVEDGRIAFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDESGKVYVGRDEAEVRAKNNLGPEIALQQDNDVLDTWFSSGLWTFSTLGWPEKTKALETFHSTDVLVTGFDIIFFWVARMIMLTMHLVKNEDGTPQVPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGIDLETLVEKRTSGLMQPQLAKKIEKQTRQEFADGIASYGTDALRFTFCSLASTGRDIKFDMGRVEGYRNFCNKIWNAARYVLDKGEDCGQNGEAVELSLADRWIISQLQRTEAEVTRQLDQFRFDLAAQALYEFIWNQYCDWYLELSKPVLWDETAPVERQRGTRRTLVRVLEVALRLAHPFMPFITEEIWQRLAPLAGAQGKTIMLQPWPVANEARIDQAAEDDIEWLKGLMLAVRNIRGEMNIGPGKPLQLFLKNVSAEDQRRLSENDYLLKKLAKLESMTVLTEGAEAPLSATALVGDMEVLVPMAGLIDKGAELARLDKEIQRLQGEVQRVGGKLSNAAFVDKAPPEVIAKERAKLTEAEQALGKLAEQHARIASL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_AGGAC
Sequence: MFKKSMNIADYDPVLWQAIENENRRQEEHIELIASENYASPRVMQAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAIERAKELFGADYVNVQPHSGSQANAAVYMGLLNPGDTILGMSLAHGGHLTHGASVSFSGKIYHAEQYGITDEGLIDYDALRKQAHDVKPKMIVGGFSAYSQVVDWKKMREIADEVGAYLFVDMAHVAGLVAAGIYPNPLPYAHVVTTTTHKTLGGPRGGLILSSCGDEEIYKKLNSAVFPAGQGGPLVHIIAAKAVCFKEALEPEYKVYQQNVLKNAKAMVEVFKQRCYKVVSNGTENHLFLVDLVSHGLTGKAADAALGKANITVNKNSVPNDPQKPFITSGIRVGTPSVTRRGFNEADVKELAGWMCDVLDAIGKDNEAEVIADTKDKVLAICKRLPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGTB1_DICDI
Sequence: MGSCINEEKLAKFFQRSLNALPAPYTSGLPNHLSLIFFVVSGLDLLNKTDILEKEKQDIINWVYSRQILPSKDNPEINLENCGFRGYNFLGQEFCCDKSVHTSENGPLEYDLPSTPNTYCALLILRILGDDFSGVNKKAIIDSLRKRQRESDGAISGSPNVGDYDLRHLFSACAISFILDDWSAINKESAIDYIKSCLSYEFAFGQTPQQEAHGGPTYCAIASLSLLGRLDVLEPFKEQLTFWLVKKQITGFCGRTNKDPDTCYAFWIGASLMMIDRYDLIDFASINAFIGSAQHEAIGGVAKEPGQLPDVMHSYLSLVGLSFGNIPSIQQVIPCLNLSKRAAGKDWFEKLI
What is the function of this protein?
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
What are the official names of this protein?
Geranylgeranyl transferase type-1 subunit beta, Geranylgeranyl transferase type I subunit beta, GGTase-I-beta, Type I protein geranyl-geranyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit beta family.