PharMolix/UniProtQA huggingface dataset:
Protein: ADA1A_CANLF
Sequence: MVFLSGNASDSSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQITEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPVGGTGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIG
What is the function of this protein?
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.  Its effect is mediated by G(q) and G(11) proteins.  Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
What are the official names of this protein?
Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK- mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity).
Protein: ERFB_DEBHA
Sequence: MSRRERYSVEPIPNDANEFQDNVSFIHKFITNWLITDPSLRNPGSEKNVKAKNYQVQKHENVQFIYLCGGRLRSVKQKPINVVTGISILIPGILFWIFEAKWIWFHVNPSIVILFSYFWLITVSFFIKASMSDPGMLPRNIHVPYSISNANTSPKASPPDEYFNIISLPYNAEDHTGVGLKYCATCHIWRSPRASHCSVCNSCIISHDHHCVFLNNCIGYRNYKYFLWFLLFAVLGCILMSVISFIHVFYYRLGMETSVSTFRSSISKYPVSFLLCIYSLLALVYPFPLLIFHIFLTSYNLTTREYFNNVRGVKNSQNHFTNHFDTHSIFKNLYINWLGRARGFSLVRQTDSYQIGDLRFEKLDPLQSFSS
What is the function of this protein?
The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.
What are the official names of this protein?
Palmitoyltransferase ERF2, DHHC cysteine-rich domain-containing protein ERF2, Ras protein acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: KDSA_CHLTA
Sequence: MFPENKMLLIAGPCVIEDNSVFETARRLKEIVAPYASSVHWIFKSSYDKANRSSVHNYRGPGLKLGLQTLAKIKEELDVEILTDVHSPDEAREAAKVCDIIQVPAFLCRQTDLLVTAGETQAIVNIKKGQFLSPWEMQGPIDKVLSTGNNKIILTERGCSFGYNNLVSDMRSIEVLRRFGFPVVFDGTHSVQLPGALHSQSGGQTEFIPVLTRSAIAAGVQGLFIETHPNPSSALSDAASMLSLKDLERLLPAWVQLFTYIQEMDAVSV
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHJ_CRUWA
Sequence: MQGTLSVWLAKRGLVHRSLGFDYQGIETLQIKPEDWHSIAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGVNQAEEVCIKVFTHRSNPRIPSVFWVWKSTDFQERESYDMLGITYDSHPRLKRILMPESWIGWPLRKDYIAPNFYEIQDAY
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: GREA_XANAC
Sequence: MRAPMTSKGAQRLREELEHLKSVKRPEVINAIAEARAHGDLKENAEYHAAREQQSFIEGRIKQLESELSHAEIIDITKLSAGTKIVFGATVTLADTETDEEKRYQIVGDLEADIKMGLIAISSPLARALIGKLEGDSVTIDAPAGQREYEVVSVAYLD
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TMCAL_STRP4
Sequence: MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAIVDKWTRAQMALENGADLVVELPFLVSVQAADFFGQGAVDILDRLGIDSLVFGTEEVRDYQKIADLYTEKGAEMEKFVENLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYAKAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQASKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVELVTTKRYTKARVRRLLTYILVQARESDLPEGIHVLGFTEKGRQHLKYLKGQVSLVSRIGKEPWDVMTQKADQIYQLGNPSIAEQNFGRVPIRIETN
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6E_SULIM
Sequence: MPDFKIVISDPQSVEPKRIKVKAKANDQIKSIAGEKEGKAVPQAKVNEKTKQLLNIDTLITLEITKQEGDKKVKVKSHFKVEVDNNVPDNEVWISKTMAEKFGAEDFEAIAYRTKTLQISIDQDKATNLVGLKIGDTFEANQLIGLPVKLKITGGSDNSGFPMRFDVTGAAKRKILLSGPPGFYPNEDGERRRKTIRGNTISQEIVQINTIIVR
What are the official names of this protein?
30S ribosomal protein S6e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: MDH_CHLTR
Sequence: MVSQTVSVAVTGGTGQIAYSFLFSLAHGDVFGLDCGIDLRIYDIPGTERALSGVRMELDDGAFPLLQRVQVTTSLHDAFDGIDAAFLIGSVPRGPGMERRDLLKKNGEIFATQGKALNTTAKRDAKIFVVGNPVNTNCWIAMNHAPRLLRKNFHAMLRLDQNRMHSMLSHRAEVPLSAVSQVVVWGNHSAKQVPDFTQALINDRPIAETIADRDWLENIMVPSVQSRGSAVIEARGKSSAASAARALAEAARSIYQPKEGEWFSSGVCSDHNPYGLPEDLIFGFPCRMLATGEYEVIPRLPWDAFIRGKMQISLDEILQEKASVSL
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: NU3C_PROM1
Sequence: MFSLQGYEYFLGFLLISGAVPILALTTNKLIAPKSKAGERQLTYESGMEPIGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFHKLGLLAFIEALVFITILVVALAYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: LACB_PIG
Sequence: MRCLLLTLGLALLCGVQAVEVTPIMTELDTQKVAGTWHTVAMAVSDVSLLDAKSSPLKAYVEGLKPTPEGDLEILLQKRENDKCAQEVLLAKKTDIPAVFKINALDENQLFLLDTDYDSHLLLCMENSASPEHSLVCQSLARTLEVDDQIREKFEDALKTLSVPMRILPAQLEEQCRV
What is the function of this protein?
Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
What are the official names of this protein?
Beta-lactoglobulin-1A/1C, Beta-lactoglobulin IA/IC, Beta-LG.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SELA_MOOTH
Sequence: MESRNLLRQLPAVDQLLQHPRLKDLSRENYKMVLALTRQVLDDWRLKIKNGATTIPDPGQLAREIENRYHEAGRSSLRPVINATGVVLHTNLGRAILSPAARAAALTAAGRYTNLEYDLEKGQRGNRYSHVTGLLKELTGAEEALVVNNNAAAVLLALSTLAAGRETIISRGQLVEIGGSFRIPEVMGQSGTRLVEVGTTNKTYIHDYERAVGPDTALLLKVHPSNYRIQGFTREVTTAELVELGRRVGVPVMEDLGSGFLIDLEAYGITGEPTVQAEINQGVDVVTFSGDKLLGGPQAGIIVGRRDLVAAMAGHPLTRALRIDKMNLAALEATLRAYRNPDRAVKEIPTLAALVALPEDLRLRAEELQKLLTSVLGSRARVGLMPTTSQAGGGSLPVTELPSWAITIRPEQGGAAGLVTALRRTDPPVLARVQDDLLLLDVRTLLPGEGEELARALVQALEGAVHGGES
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAX1_HUMAN
Sequence: MKFTLGLGSRAWRVSWEGAAAAAAGPGAGGSALRCRAQRVSSPRLGRRGSRLSGALPLCLSRGGGGAQALPDCAGPSPGHPGHPGARQLAGPLAMEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEASKQPPSQPTLPYNHIYQYPYPSPVSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILGIRTFMEQTGALAGSEGTAYSPKMEDWAGVNRTAFPATPAVNGLEKPALEADIKYTQSASTLSAVGGFLPACAYPASNQHGVYSAPGGGYLAPGPPWPPAQGPPLAPPGAGVAVHGGELAAAMTFKHPSREGSLPAPAARPRTPSVAYTDCPSRPRPPRGSSPRTRARRERQADPGAQVCAAAPAIGTGRIGGLAEEEASAGPRGARPASPQAQPCLWPDPPHFLYWSGFLGFSELGF
What is the function of this protein?
This protein is a transcriptional activator.  It may play a role in the formation of segmented structures of the embryo.  May play an important role in the normal development of the vertebral column (By similarity).
What are the official names of this protein?
Paired box protein Pax-1, HuP48.
What are the subcellular locations of this protein?
Nucleus.
Protein: MT_POVM1
Sequence: MDRVLSRADKERLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMNLGGTGFQVRRLHADGWNLSTKDTFGDRYYQRFCRMPLTCLVNVKYSSCSCILCLLRKQHRELKDKCDARCLVLGECFCLECYMQWFGTPTRDVLNLYADFIASMPIDWLDLDVHSVYNPKRRSEELRRAATVHYTMTTGHSAMEASTSQGNGMISSESGTPATSRRLRLPSLLSNPTYSVMRSHSYPPTRVLQQIHPHILLEEDEILVLLSPMTAYPRTPPELLYPESDQDQLEPLEEEEEEYMPMEDLYLDILPEEQVPQLIPPPIIPRAGLSPWEGLILRDLQRAHFDPILDASQRMRATHRAALRAHSMQRHLRRLGRTLLLVTFLAALLGICLMLFILIKRSRHF
What is the function of this protein?
Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase-associated growth-factor receptor.  Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity.  Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division.  MT also plays a role in regulation of early and late gene expression and in viral DNA replication.
What are the official names of this protein?
Middle T antigen, MT, MT-AG.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RRF_CORJK
Sequence: MIDDILLESEERMTSSVEHAREDLTTIRTGRANPSMFNGVVAEYYGVPTPITQMATISVPEPRMLLIKPYEQSTMDAIENAIRNSDLGVNPTNDGQVLRVTIPQLTEERRKEMVKVAKSKGEDAKIAIRNIRRKGMEQLGKIQKDGEAGEDEVRAAEKDLEKITHSYVEQVDSLVEAKEKELLEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPN_CAUVC
Sequence: MRTDTPQAVNLADYRPFPFAIETTRLVFDLHPTRTRVSAELSVRRTGGKNEPLVLNGERLKLVSIAIDGRPLAAGEYGVDAERLTIAEAPDAFVLTTEVEIDPSSNKALMGLYMSGGRFCTQCEAEGFRTITYFPDRPDVLSRYSVRIEADGKFPHLLSNGNPVASGSLDGGRHFAEWSDPFPKPSYLFALVAGDLDVLADKFITMSGREVALRVFVDPGQASRAAYALDSLKRAMKWDEEAFGREYDLDLFMIVAVRDFNFGAMENKGLNIFNSSLLLADPQTATDLDYERIEAVVAHEYFHNWTGNRITCRDWFQLCLKEGFTVFRDQGLSADMRGAAVQRIKDVRALRARQFAEDAGPLAHPVRPSSYLKIDNFYTATIYEKGAEIIRMLKAILGAPAFRKGCDLYFQRHDGEATTVEAFIACFAEASGRDLSGFFGWYEQAGTPSVTIETAYDAAAGALTLTLTQSTSPTPGQPDKKPLPIPIAIGLLAADGRVLRDTEIVLLDQAQMTVRWDSIPEPPVLSALRGFSAPVNLSTDARPSDRYVLFGSDTDLFNRWEAGQTLARDLILTRAAGAPDEVGEERYADALGRALVDDAAEPAFKALLLALPSEPDLALMFEAADPAALHAARDHLRTRIAVHLGDLLRRLHGEMQINGEFSSDAAAAGRRALRNACAEALSADPHAENLARLLGHFGAARNMTDMIGGLYPMVAMGGVPREKALESFHHAWRTEPLVLDKWFAVQGRDPNPDALERVIALTQHPDFEPTNPNRLRALVSTFANFNPARFHDPSGAGYAFLADEILKVDAFNPMTAARLVEPLGGWRRYKPELGDLMRAQLERIVAHPNLSKNVLELASKALG
What is the function of this protein?
Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
What are the official names of this protein?
Aminopeptidase N, Alpha-aminoacylpeptide hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
Protein: AHSA1_HUMAN
Sequence: MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF
What is the function of this protein?
Acts as a co-chaperone of HSP90AA1 (PubMed:29127155).  Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155).  Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).  Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).
What are the official names of this protein?
Activator of 90 kDa heat shock protein ATPase homolog 1, AHA1, p38.
What is the protein family that this protein belongs to?
Belongs to the AHA1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.
Protein: CYO18_VIOOD
Sequence: GIPCGESCVYIPCTVTALAGCKCKSKVCYN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cycloviolacin-O18.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: TRUA_OLEA2
Sequence: MARLKLIIAYAGTRYAGWQIQCLPAGRPHAVQQPTVQQAVEDAAKAILGSAVRVHGAGRTDSGVHAEGQVAHLDIPDAKAAVDWRRALNAKLPEDISVLQAAVVPDGFHARFDAVKKRYTYRIWLTRAFVLPQRRPFVHMTGPLDIAAMDAAAAFMTGTHDFASFQNAGTELATTVRTVYSITRTPGLAPDDFPRSHDTTPRAPLELAWHFEADGFLKQMVRNMMGLLLWTGTGRCAPEDVPAIIAARDRRLSAPTAPACGLTMERVFYPDECCPPES
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: RL19_SHEB2
Sequence: MNNIIKMLNDEQMKQDVPAFGAGDTVVVQVRVKEGDKERLQAFEGVVIAKRNRGLHSAFTVRKISNGEGVERAFQTHSPLIASIEVKRRGRVRRAKLYYLRDRSGKSARIREKLATK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MOAC_STAA1
Sequence: MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIFKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSGQ
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: RF3_YERE8
Sequence: MSPSEYALEVAKRRTFAIISHPDAGKTTITEKVLLFGNAIQTAGTVKGRGSSHHAKSDWMEMEKQRGISITTSVMQFPYGGCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDRDIRDPMEVLDEVERELKIACSPITWPIGCGKLFKGVYHLYKDETYLYQTGKGHTIQEVRIVKGLNNPDLDVAVGEDLAKQFRQELELVQGASHEFDHDAFLSGDLTPVFFGTALGNFGVDHMLDGLVEWAPAPMPRQTDTREVVAAEEKFTGFVFKIQANMDPKHRDRVAFLRVVSGRFEKGMKLRQVRTKKDVVISDALTFMAGDRSHLEEAYAGDIIGLHNHGTIQIGDTFTQGEDMKFTGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLTNNDLIVGAVGVLQFEVVSSRLKSEYNVEAVYESVNVSTARWVECDDVKKFEEFKRKNEVNLALDGGDNLSYIAPTMVNLNITQERYPEVRFRKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPME1_CANGA
Sequence: MGDDLKRKILLHNLSSNNPILEKLKGGQEPNSNEEGSDSIGDLPSLKNDYKRQDNNSTNCTYIPPSQWNTYFRSNEHIKVQSRNIEFNTYYTVPSSILGPSLPVFIFHHGAGSSGLSFANLARNLGDQLNNNCCCLSFDARGHGGTKFIDAKQAQNYFRDDFVDDFHTLVEYFVSEKLKHLPTEKLSIIFIGHSLGGSICTFTYSKLSIELKKQVIGVAMFDIVEEAATLALEKVNHFLQVTPNMFSGYEEAIDWHVSHELSRLRESADIAIPALFKSTESGKVVRITNLETFRPFWRTWFSDLSKSFVSLPTCKLLILAGNDNLDRELIIGQMQGKYQLVVFQDSGHFIQEDTPRKTALTLVDFWKRNDNKNVVIKSNWGSSNKV
What is the function of this protein?
Demethylates proteins that have been reversibly carboxymethylated.  Demethylates the phosphatase PP2A catalytic subunit (By similarity).
What are the official names of this protein?
Protein phosphatase methylesterase 1, PME-1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: RPSC_MYCTU
Sequence: MTATASDDEAVTALALSAAKGNGRALEAFIKATQQDVWRFVAYLSDVGSADDLTQETFLRAIGAIPRFSARSSARTWLLAIARHVVADHIRHVRSRPRTTRGARPEHLIDGDRHARGFEDLVEVTTMIADLTTDQREALLLTQLLGLSYADAAAVCGCPVGTIRSRVARARDALLADAEPDDLTG
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  Extracytoplasmic function (ECF) sigma factors are usually held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; this sigma factor does not seem to have a cognate anti-sigma factor however.  It has been suggested that the sigma domains 2 and 4 may interact via polar residues in this protein to autoregulate.  Positively regulates expression of a small regulon of genes.
What are the official names of this protein?
ECF RNA polymerase sigma factor SigC, ECF sigma factor SigC, Alternative RNA polymerase sigma factor SigC, RNA polymerase sigma-C factor, Sigma-C factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
Protein: APOE_CAMDR
Sequence: MKALWVALVVTLLAGCRAEVEPEPEPEVQLGQEQPEWQGSQPWELALGRLWDYLRWVQTLSDQVQEELLSTQVTQELTALMEETMKEVKAYKAELEEQLSPVAQETRARLSKELQAAQARLGTDMEDLRSRLAHYRNEVQAMLGQTTDELRNRLASHLRKLRKRLLRDAEDLQKRLAVYRAGAVEGAERSVSALRERLGPLVEQGRLGTATTSTLGSQPLRERAEAWGQKLRGRLEAVGARAQDRLDKMREQLEEVRAKVEEQASQMRLQAETFQARLKGWFQPLVEDLQRQWAGLVEKVQQLAVGTTPTPAASKNQ
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: NCAP_TSWVL
Sequence: MSKVKLTKESIVALLTQGKDLEFEEDQNLVAFNFKTFCLENLDQIKKMSVISCLTFLKNRQSIMKVIKQSDFTFGKITIKKTSDRIGATDMTFRRLDSLIRVRLVEETGNSENLNTIKSKIASHPLIQAYGLPLDDAKSVRLAIMLGGSLPLIASVDSFEMISVVLAIYQDAKYKDLGIDPKKYDTKEALGKVCTVLKSKAFEMNEDQVKKGKEYAAILSSSNPNAKGSIAMEHYSETLNKFYEMFGVKKQAKLTELA
What is the function of this protein?
Encapsidates the RNA.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the tospovirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: PYRB_SALDC
Sequence: MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLSASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGQVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHIAMVGDLKYGRTVHSLTQALAKFSGNRFYFIAPDALAMPQYILDMLDEKGMAWSLHGSIEEVMADVDILYMTRVQKERLDPSEYANVKAQFVLRASDLNGARENMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSELSL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: LIM1_LILLO
Sequence: MASMKSLATAILVVLLLAALSREGRSQNCSAAIGELMTCGPYVLPGNNGAPSEQCCSALRAVNHGCLCETINIISSLPDHCSLPAVNCAA
What are the official names of this protein?
Protein LIM1.
What is the protein family that this protein belongs to?
Belongs to the A9/FIL1 family.
What are the subcellular locations of this protein?
Secreted.