PharMolix/UniProtQA huggingface dataset:
Protein: MNMG_EHRCJ
Sequence: MSHYDVVVIGGGHAGCEAAAAASRIGAKTLLITHSISTIGEMSCNPAIGGIAKGTVVREVDALDGLMGKVIDKASIHSSILNRSKGPAVWGPRAQADRLIYKQTMQEIILNYPNLTVLEASVEDFTITQDNQKDSVKAVITSEQHTIYTSKLILTTGTFLQGTIHIGSYTTPAGRIGEQPSIGLAKTLEKYNFKLGRLRTGTPPRLDINSINFAVLQEQKGDIHPSPFSYISQSIDLPQISCYLTATNNKTHEVIKNNLHRAAASNLLKDIKAPRYCPSIEEKVRRFSDRNSHQVFLEPEGLNSDIIYPNGITTSSPLDVQYEMLKTIPGLEKVNIVRSGYSVEYNFIDPRELYHTLETKKISGLYFAGQINGTTGYEEAAGQGIIAGINAALSLSSNYEPFILKRSDAYIGVMIDDLVTLGTSEPYRLFTSRAEYRLRLRSDNADLRLTELGYKVSAVSSKRYCALKNKQHDIESLTNILKNIIITPTQLAAYDIPVSQDGVKRSIFDLLSHPNINIETVSKICDVIKKFSKAVVSQVEIEGKYAPYFIRQDADIQDFIEEENTHIPSNIEFSQIHGLSKEIQEKLAHIKPPSIGSARRIPGVTPAAITSILIYLRYHKNKKIS
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_SCHPO
Sequence: MSDDRINYLKNKLVQYPDFPKKGILFEDIMPIFQDPRAFGILIDLLLEAVETEFNNIDVIVGLEARGFLFGPTLALRANCAFVPVRKPNKLPGDLVVVSYNKEYSTDSFAIQKGTIKPGQRVLIVDDILATGGTALAADELVTRLGGELVGHLFLLELTFLQGRKRLMAPTYTLLTGQDEAPDGSEFA
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RECA_PROMI
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMNVETISTGSLSLDVALGAGGLPRGRIVEIYGPESSGKTTLTLQVIASAQREGKICAFIDAEHALDPIYAQKLGVDIDNLLCSQPDTGEQALEICDALSRSGAVDVIVVDSVAALTPKAEIEGEIGDSHVGLAARMMSQAMRKLAGNLKNSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGSVKNGDEVIGSETRVKVVKNKVAAPFKQAEFQIMYGEGINTYGELIDLGVKHKLVEKAGAWYSYNGEKIGQGKANATNYLKEHPEMYNELNTKLREMLLNHAGEFTSAADFAGEESDSDADDTKE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_STRP4
Sequence: MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINTHHTNKHYFKDVVLDENIIAYTDLAETLKDVDAILFVVPTKVTRLVAQQVAQTLDHKVIIMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAXETIVRDLTLITAASKDLQTAQYVQELFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAIIARGLAEITRLGVALGANPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIEANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAENEWS
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_TECST
Sequence: SVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEADQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAAEGNTIIREASKWSLELAAACEVWKEIKFEFAAVDTLDR
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DRP2_RAT
Sequence: MQPLVMQGCPYTLPRCHEWHAADRFHHSSSLRNTCPQPQVRAAVTIPAPPWDGAGDPCLSPKLLNGSVGAVGPLEPSAMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSKGPYIYSVLESAQAFLSQHPFEELEESHSESKDTSPRQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIEHTLEHLLEIQGAMEELSSTLTQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPVKDGVKLVNDLAHQLAISDVHLSMENSRALEQINVRWKQLQVSVAERLKQLQDAHRDFGPGSQHFLSTSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQASEHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKTGIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGALLHEAIQVPRQLGEVAAFGGSNVEPSVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTVAEQVKHQTKCSICRQCPIKGFRYRSLKQFNVDICQTCFLTGKASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFRSKQYFSKHPQRGYLPVQSVLESDCSETPASSPMLPHADTHSRIEHFASRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSMATESKGELEKILAHLEDENRILQGELRRLKWQHEEAVEAPTLAEGSAEATPDHRNEELLAEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGNGSAGSSLASSPRQSEGSHPREKGQTTPDTEAADDVGSKSQDVSLCLEDIMEKLRHAFPSVRSSDVTANTLLAS
What is the function of this protein?
Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells.  Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane.  Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
What are the official names of this protein?
Dystrophin-related protein 2, DRP-2.
What are the subcellular locations of this protein?
Postsynaptic density. Cell projection, dendrite. Perikaryon. Cell membrane; Peripheral membrane protein. Note=Detected in Schwann cells at periaxonal myelin membranes.
Protein: P5CR_ACTCC
Sequence: MAAAAFVPIPTDTYKLGFIGAGKMAESIARGVVKSGVLPASRIRTAHLGSARRDAFESFGVKVLDRNDQVVEDSDVIIFSVKPQIVKEVVLQLRPLLSEKQLLVSIVAGVKLKELEDWAGHSRFIRVMPNTPAAVGEAASVMSLGATATGEDGELITKLFGAIGKIWKADEKLFDAVTGLSGSGPAYIFLAIEALADGGVAAGLPRELALGLASQTVLGAASMVARGGKHPGQLKDDVASAGGTTIAGIHELEKGGFRGTLMNAVVSATKRSQEIFKR
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_BRUC2
Sequence: MNSRLIVTGTDTGIGKTVFSAALCHALGAAYWKPVQSGLEEETDSEIVARLAQASPQRILPEAWRLNTPASPHLSARLDGVEIRPEEMHIPATSLPLVIEGAGGLLVPLNDKTLFADLFAIWRIPAILCARAALGTINHTLLSLEAMRSRDIPVLGVAFIGEANEDTETTIAHLGRVKRLGRLPLLDDLSPEKLHHSFARNFHIDDFAGVAR
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMB_CLOK5
Sequence: MKIDIIISADDIKKEKILHKSVIVVDMLRATSVIITAINNGCREVIPVLTIEEALEIYHKNREKYVMGGERKALKIEGFHCSNSPLEYSRQVVENKTLVITTSNGTKAIKGSIMAKNILIGALINADEVANRSINLNNDVVIVNAGTCGQFSIDDFICSGYMINCVIKKIKVDLTDIARTALYIYEQNPDIITFIKKASHYKRIKKLKLYDDLEYCCRKDIIKIVPEYIDGIIKCNKLIY
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: FPG_SYNEL
Sequence: MPELPEVETVRRGLELVTLKQPIVDVEVLLARSIALPKEPQAFIEHLRDRRIEQWQRRGKYLLATLDDGSRLVIHLRMSGQLLWLTTPQPPCPHTRVRWFFPTRAELRFVDQRTFGRCWWLPPDCRVAEAIPALATLAPEPLSEAFTVAFLAARLAHCRRSIKTALLDQSIVAGMGNIYADESLFLSGLHPTQSAHTLTPEQVQRLHGVICQVLREGIAAGGTTIRTFMSPAGVNGHYGGQAWVYGRKGEACRVCGTTIERLRLAGRSSHYCPQCQPLSSAIGK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RK12_NICSY
Sequence: MASTLSTITLRSPSPSTATSTHASIPFPKKTLEFPIRTPKLQNRRATFLRPLAAVEAPEKVVQLGDEISNLTLADAQKLVEYLQDKLGVTAASFAPAAVVAAPGAAAEAPAVVEEKTEFDVVIDEVPSNARIATIKAVRALTSLALKEAKELIEGLPKKFKEGVSKDEAEDAKKQLEEAGAKVSIA
What are the official names of this protein?
50S ribosomal protein L12, chloroplastic, CL12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BTUF_YERPP
Sequence: MMPLGLFPLPRAAAVLLISLLTLPAQAAERVISLSPSTTELAYAAGLGDKLVAVSAYSDYPESAKKLEHVASWQGINVERILALKPDLILAWRGGNPQRPLDQLAALGIPIFYSDPTHIDQIASDLDKLAQYSPHPEQAHQAAEQFRQHVNTLRDRYARSQPKRTFLQFGTQPLFTSSGHTLQSEVVSLCGGENIFADSRVPWPQVSREQVMTRKPQVIVVSGTQSQVDNVSAFWLPQLVVPVIALNEDWFNRASPRILLAAQQLCQQMASIPTPVAESH
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
What are the official names of this protein?
Vitamin B12-binding protein.
What is the protein family that this protein belongs to?
Belongs to the BtuF family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RK35_ARATH
Sequence: MASLSMASVNVSFCHPLRSSSPKVSLRSSVHFATSLSSSHSISGLRAVLPLKISTVASPNSQKLHSFTVFAHKGYKMKTHKASAKRFRVTGRGKIVRRRSGKQHLLAKKNNKRKLRLSKMTEVNRSDYDNVIGALPYLKVNRKAT
What are the official names of this protein?
50S ribosomal protein L35, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: E4PD_ERWT9
Sequence: MTVRIAINGFGRIGRNVLRALYETGRRAEISAVAINELADAAGMAHLLKYDTSHGRFAWDVRQERDLLTVGDDTIRLLHIPEIGSLPWRELNVDIVLDCTGVYGSRADGEAHLKAGARKVLFSHPGGHDLDATVVYGVNEKELLPEHLLVSNASCTTNCIIPIIKLLDDAWGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTRLAAGITRIFPKFNDRFEAIAVRVPTINVTAIDLSVSVRDAVKASEVNALLHSASLGAFSGIVDYTELPLVSIDFNHDPHSAIVDGTQTRVSGQHLIKTLVWCDNEWGFANRMIDTTLAMAASGFSLDAAASIKL
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_CHLPB
Sequence: MPNVTVALLFGGKSSEHEISIISAKAVSAHIDRTTYTLFPLYISRDGRWFKGRTARKVLDLDITGLLKSRTIETTNRQLLAMTENRDEDLFDFNFQKEGIEVAFPVLHGAYGEDGKIQGLLEVFAIPYTGCNVQSSSMTMDKEITKLCAVQAGIHVADYMTVLRPDYLNNRSAIAETIKKRFAPPFFVKPANLGSSVGIAKIHSFDELENALDEACRLDVKILVEKAIEGREVEVAVLGNEHPIASVPGEIEPGGDFYDFTDKYIDGSARLHIPARVDADTSARLQEEGIKAFRALGCSGMSRIDFFVEKGSGRIILNEINSIPGFTSISMYPMLMEHAGIGFTELIDRLVRFALEKTPA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H13M1_CYRHA
Sequence: MKTAIFTVVLALAVFAVLSFGWEANEKALSEEFTELIHEKEAASETEARECRYFWGECHDHMPCCDWLVCRYKWPITYNIRVWNRTFPEK
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U7-theraphotoxin-Hhn1k, U7-TRTX-Hhn1k, Hainantoxin-XIII-13, HNTX-XIII-13.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 13 (Hntx-13) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL3_RUMCH
Sequence: MKKAMLGKKIGMTQIFDENGLVIPVTVVEAGPLTVVQKKTVETDGYDAIKVGYVKVAEKKLSKPNLGQFSKTKLAPMKHLKEFRLEDISGFEVGQEIKAENMFQSGDKIDVSGVSKGKGFQGVTKRYGQRTGPNTHGSMYHRRIGSMGSGTNPGRVFKGKKLPGHMGRETITVQNLEVVRVDSDRNLILIKGAIPGPKGGLLVIKNTVKSGK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: F16PA_SYNP2
Sequence: MPDHNNDITQSPSLDRDCTTLSRHVLQQLQSFDTAAQDISAIMNRIALAGKLVARRLSRAGLMEGVLGFTGEENVQGESVKRMDLYANDVFISVFKQSGLVCRLASEEMEKPYYIPENCPIGRYTLLYDPIDGSSNVDINLNVGSIFSIRQQEGMDLDGDAADLLQNGHKQIAAGYILYGPSTMLVYSIGTGVHSFILDPSLGEFILAEENITMPNHGSIYSVNEGNFWQWEDSIRDYIRYMHRHEGYTARYSGALVGDLHRILMQGGVFLYPGTKKKPEGKLRLLYETAPLAWLIEQAGGKASTGTMPLLDFVPTYLHQRTPTILGSVENVELVESFIQEAERETVGV
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLCD_MACFA
Sequence: MDLAGLLKSQFLCHLVFCYVFIASGLIINTVQLFTLLLWPINKQLFRKINCRLSYCISSQLVMLLEWWSGTECTIFTDPRAYPKYGKENAIVVLNHKFEIDFLCGWSLSERFGLLGGSKVLAKKELAYVPIIGWMWYFTEMVFCSRKWEQDRKTVATSLQHLRDYPEKYFFLIHCEGTRFTEKKHEISMQVARAKGLPRLKHHPLPRTKGFAITVRSLRNVVSAVYDCTLNFRNNENPTLLGVLNGKKYHADLYVRRIPLEDIPEDDDRCSAWLHKLYQEKDAFQEEYYRTGTFPETPMVPPRRPWTLVNWLFWASLVLYPFFQFLVSMIRSGSSLTLASFILVFFVASMGVRWMIGVTEIDKGSAYGNSDSKQKQND
What is the function of this protein?
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).  Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity).
What are the official names of this protein?
1-acyl-sn-glycerol-3-phosphate acyltransferase delta, 1-acylglycerol-3-phosphate O-acyltransferase 4, 1-AGP acyltransferase 4, 1-AGPAT 4, Lysophosphatidic acid acyltransferase delta, LPAAT-delta.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RHAB_SALSV
Sequence: MTFRHCVAVDLGASSGRVMLARYDSKHRTLTLREIHRFVNCLQKTDGFDTWDIDSLEKDIRLGLKKVCNEGILIDSIGIDTWGVDYVLLDKQGQRVGLPVSYRDNRTTGIMSQALVQIGKSEIYRRSGIQFLPFNTIYQLRALTKQQPELTAQVAHALLMPDYFSYRLTGEMNWEYTNATTTQLVNINTDDWDDTLLAWTGAKKGWFGRPSHPGNVIGDWICPQGNRIPVVAVASHDTASAVIASPLANKHSAYLSSGTWSLMGFESKMPYTTDEALAANITNEGGAEGRYRVLKNIMGLWLLQRVLKERRITDLPALIAQTEALPACRFLINPNDDRFINPDDMRAEIQAACRETDQPVPVSDAELARCIFDSLALLYADILHELANLRGEKFTQLHIVGGGCQNALLNQLCADACGIRVMAGPVEASTLGNIGIQLMTLDELNNVDDFRQVVSANYDLTTYIPNPDSEIARHVAQFQPKRQTKELCA
What is the function of this protein?
Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose).  Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.
What are the official names of this protein?
Rhamnulokinase, RhaB, ATP:L-rhamnulose phosphotransferase, L-rhamnulose 1-kinase, Rhamnulose kinase.
What is the protein family that this protein belongs to?
Belongs to the rhamnulokinase family.
Protein: DNM3L_MOUSE
Sequence: MGSRETPSSCSKTLETLDLETSDSSSPDADSPLEEQWLKSSPALKEDSVDVVLEDCKEPLSPSSPPTGREMIRYEVKVNRRSIEDICLCCGTLQVYTRHPLFEGGLCAPCKDKFLESLFLYDDDGHQSYCTICCSGGTLFICESPDCTRCYCFECVDILVGPGTSERINAMACWVCFLCLPFSRSGLLQRRKRWRHQLKAFHDQEGAGPMEIYKTVSAWKRQPVRVLSLFRNIDKVLKSLGFLESGSGSGGGTLKYVEDVTNVVRRDVEKWGPFDLVYGSTQPLGSSCDRCPGWYMFQFHRILQYALPRQESQRPFFWIFMDNLLLTEDDQETTTRFLQTEAVTLQDVRGRDYQNAMRVWSNIPGLKSKHAPLTPKEEEYLQAQVRSRSKLDAPKVDLLVKNCLLPLREYFKYFSQNSLPL
What is the function of this protein?
Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (PubMed:11719692, PubMed:15318244, PubMed:15671018, PubMed:24074865).  Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:15671018).  Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:15671018).  Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (By similarity).  Plays a key role in embryonic stem cells and germ cells (PubMed:11719692, PubMed:15318244, PubMed:24074865).  In germ cells, required for the methylation of imprinted loci together with DNMT3A (PubMed:11719692).  In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (PubMed:15318244).  Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (PubMed:24074865).  While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (PubMed:24074865).  Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (PubMed:24074865).  Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (PubMed:24074865).
What are the official names of this protein?
DNA (cytosine-5)-methyltransferase 3-like.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDC5_YEAST
Sequence: MSEITLGKYLFERLSQVNCNTVFGLPGDFNLSLLDKLYEVKGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISSQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIANAPAEIDRCIRTTYTTQRPVYLGLPANLVDLNVPAKLLETPIDLSLKPNDAEAEAEVVRTVVELIKDAKNPVILADACASRHDVKAETKKLMDLTQFPVYVTPMGKGAIDEQHPRYGGVYVGTLSRPEVKKAVESADLILSIGALLSDFNTGSFSYSYKTKNIVEFHSDHIKIRNATFPGVQMKFALQKLLDAIPEVVKDYKPVAVPARVPITKSTPANTPMKQEWMWNHLGNFLREGDIVIAETGTSAFGINQTTFPTDVYAIVQVLWGSIGFTVGALLGATMAAEELDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYIFVLNNNGYTIEKLIHGPHAEYNEIQGWDHLALLPTFGARNYETHRVATTGEWEKLTQDKDFQDNSKIRMIEVMLPVFDAPQNLVKQAQLTAATNAKQ
What is the function of this protein?
Second most abundant of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation.  Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways.  The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism.  Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids.  In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols.  Its preferred substrates are the transaminated amino acids derived from threonine (2-oxobutanoate), norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, also alpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate), and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucine is no substrate.  In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins.
What are the official names of this protein?
Pyruvate decarboxylase isozyme 2, Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase, 2ODC.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CWC25_CRYNJ
Sequence: MGGGDLNMKKSWHPVLLVNQERVWKAEKVANEEKKMLAQLRKEREEERQLEELHRLQEASTGKKRVEKLDWMYAAPSTEGGALGGARIGERDMEEYLLGKKRVDEVLGQGDKNIGAASREFIALQNANTARDTAAKIREDPLLAIKKQEQAALAALMNRPDIRKQLRAAKKAKETKGREGESKEERKARKRAEKEERRKSKHRYHDSRSPPSDYYDDRDHRRHRDSYDSQDRENRRTYRDRSDRSRTRSESPKREKKEKDYSNRDRDYRRRNDTTRGSFDESPRKGGGNRWGSHGPDGYRRSDHRDDGFRERQRGDRIPPPRHLSYNHSTPDVRPSSPPSSSAAPVNRNTSTLEDQRAARLAAMSASADELYSSRSKSLAARAEEERREQEKDEKMRQKYGKEQASANFFSQQSQLGLGEALQRRGGKGLLKDI
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC25.
What is the protein family that this protein belongs to?
Belongs to the CWC25 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_NEIMF
Sequence: MNKIIKGDRVVVIAGKDKGKQGQVVRVLGDKVVVEGVNVVKRHQKPNPMRGIEGGIITKEMPLDISNIAILNPETNKADRVGIKLIENEGKVKRVRFFKSNGSIIGA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RPOC1_ACOAM
Sequence: MIDRYKHQQLQIGSVSPQQISAWANKILPNGEIVGEVTKPYTFHYKTNKPEKDGLFCERIFGPIKSGICACGNYRVIGAEKEDPKFCEQCGVEFIDSRIRRYQMGYIKLACPVTHVWYLKRLPSYIANLLDKPLKELEGLVYCDFSFARPIAKKPTFLRLRGLFEYEIQSWKYSIPLFFTTQGFDTFRNREISTGAGAIREQLADLDLRIVIDNSSVEWKDLGDEGSTGNEWEDRKIGRRKDFLVRRMELAKHFIRTNVEPERMVLCLLPVLPPELRPIIQIDGGKLMSSDINELYRRVIYRNNTLTDLLKTSRSTPGELVMCQEKLVQEAVDTLLDNGIRGQPMRDGHNKVYKSFSDVIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHRCGLPREIAIELFQTFVIRGLIRQHLASNIGIAKSKIREKEPIVWEILQEVMQGHPVLLNRAPTLHRLGIQAFQPVLVEGRAICLHPLVCKGFNADFDGDQMAVHVPLSLEAQAEARLLMFSHMNLLSPAIGDPISVPTQDMLIGLYVLTMGNRRGIFVNRYNPCNRRNYQNKTVDNNNYKHTKEKKPYFLSSYDALGAYQQKRINLHSPLWLRWRLDQRVIGSREVPIEVQYESLGTYQEIYGHYLIVRSVKKEILCIYIRTTVGHISFYREIEESVQGFCRAYSYGT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.