PharMolix/UniProtQA huggingface dataset:
Protein: DAPF_CAMLR
Sequence: MKFYKYCASGNDFVIFADSEKKDRSELAKILCNRYEGIGADGLIVIVPHDRYDFEWEFYNCDGSKANMCGNGSRAAAHFAHHHLKKSQYLNFLTGAGLIKSFVDDDIVEIKLSGIKDIKEAFEYKDRIWQGCNTGVPHIVTFVDDLSEFDINLCKEVRKKYNANVNFAKVEDDEFIRVRTYERGVEDETLACGTGMGACFYLAYLNQKVKDDILIKPKSNESLYFRLEEEQIFFRGKVKCCFEADYNFT
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_BUCAT
Sequence: METLAQHRQARSSAQKVRLIVDLIRGKKVPQALNILTYTNKKAAFLVKKVVESAVANAEHNDGADIDKLRIKKIFVNEGSTMKRMMPRAKGRADRILKRTSHITVIVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: OXLA_MUSSP
Sequence: AFKDLKALGCKKAMNKFNKHTLLEYLLEEGNLSRPAVQLLGDVMSE
What is the function of this protein?
Secreted L-amino-acid oxidase that acts as a key immunoregulator.  Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively.  Also has weak L-arginine oxidase activity.  Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR.  IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer.  AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity.  Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells (By similarity).  Also regulates M2 macrophage polarization by inhibiting T-cell activation (By similarity).  Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (By similarity).
What are the official names of this protein?
L-amino-acid oxidase, LAAO, LAO, Interleukin-4-induced protein 1, IL4-induced protein 1, Protein Fig-1.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted. Lysosome. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Secreted at the immunological synapse.
Protein: UREF1_BRUME
Sequence: MRTATITEFSSSYRSLPGLLHLLQFGDSALPIGGFSFSNGLESAIQQNLVHDKETLREFTLTAMNQAATSDRIALLTAHRAARADDRGALQVIDKAVFERKLNEETRLMTVRMGRKLCELSASIIDDRLNRDWLECIKTAETPGTHPVSLGLAFAALDVDGRDAFGAQQYGVATTILGAALRLMRVSFMDTQKILLEATSTVAPAYEEIADAGIEDMASFAPMVDILAAVHVKGHVRMFMN
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF 1.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRM1_SCLS1
Sequence: MDAFRGYLAAQKGQHNQAASNNPPFHSDHEMHHYGAHPNTNAAPADDYYTPYLGLRARLSQTWINRWTILLLLIIVRLLISLSTINGDIASAKTEALSACTSVENVGSAMASMPHYLSQGVNSMAAAGITKAVNGMMEMLYLTLTGVEEIVLFVIHMMTSTYMCLITLAITGSLQVAIQMIEDVGAFMNKSIDTITGDMSSGLKSFEDDLNGFLSKINIGGIFGSSTSPPKIDLSSEINKLNSIQIDPSTMDADLAKLNASLPTFDQVQNFTDSIIKLPFEEVKKLVNESKIGYKFDDSVFPVPQKKSLTFCSDNTAIQDFFIGLVKTLNIAKKIMLIVLIIAAILACVPMAYREIWGWRSMQRRAALLKAHNYTNELDILYQAHRPYTSQFGLKLSRRFKGQKNQILARWFIAYATSIPALFVLALGMAGLFTCLCQFIILRTIEKEIPALAAEVGDFAEHVVQALNNASEAWALGANSVINNTNTDINENVFGWVNTTTGAINETLNVFTDEMTKALNVTFGGTILYKPIMGVFECLVGLKVAGIEKGLTWVSDHAHVEFPEFQPDVFSLGAAASLTNSTADDNFLANPATSTTDEITDAVVKVGKKLEAVIKQEALISASLVIVYFVIVFIGFVRVVIGMCGRDKSRAEGGSGPGTLYRNGFPHQHLPVIREEKFGSNASDGWHEEHMRAGGDTIRMPFGGDGAADDLPYDGAPAPKYEASIAPVTTEMGSERLGVVPGGRANTNRGPWVRDEKGREGWEADDAQMRATSSYGFLENGDEKSSGWGLPPRRV
What is the function of this protein?
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
What are the official names of this protein?
Plasma membrane fusion protein prm1.
What is the protein family that this protein belongs to?
Belongs to the PRM1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCSPA_STAAR
Sequence: MCIVSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAESEAETTLLRRLNRIASKNITKETHTSFLGAGVYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVSKGLHYQALQVLHTYAKTRKEFEVVEIDLDGTVTDLKKLEAAVDDDTAAVAVQYPNFYGSIEDLEKIHSFIEDKKALFIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQVNEELVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGELND
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: QUEC_CUPPJ
Sequence: MTKRAIVLLSGGLDSATVLAMAKAQGFETYALSMRYGQRHSSELDAAKQVASALGAVRHEIVDLDLRRFGGSALTDDKLDVPTGGASSGIPITYVPARNTIMLSLALGWAEAVGGRDLFFGANAVDYSGYPDCRPEYVAAYETLANLATKAGVEGDRFHVHAPIIDMTKAEIIRAGIRLGVDYSMTVSCYKADDDGRACGVCDSCRIRRAGFEAAGVPDPTRYQNA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: REX_CLOB1
Sequence: MDKKKNISMAVIRRLPKYHRYLYELLKNDVDRISSKELSEKIGFTASQIRQDLNCFGDFGQQGYGYNVSELHHQISNILGLNNPYNIIIIGAGNIGQALANYTRFSKLGFNVKAMFDTNPKLIGLKIREIEILDIDYLSSYLEKNNIDIGIICVPHDNAQKVANILVKNDIKGIWNFAPIDLSVPEDVVVENVHLSDSLLTLTCLINKTE
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_BRASO
Sequence: MSFVLAIDQGTTSSRAMVFRSDISIAAVAQQEFPQHFPASGWVEHEPEDIWTSTVMTCRDALEKAGLAAKDIAAIGITNQRETTVVWDRATGQAVHRAIVWQDRRTADICAKLKAEGHEPDVSARTGLIIDPYFSGTKVAWILDHVPGARERAERGELLFGTVDCYLLWRLTGGRVHATDATNASRTLLFNIHTGQWDDTLLKLLRVPRSMLPEVKDSSADFGTTTPDLFGGPIKVAGIAGDQQAATIGQACFTPGMMKSTYGTGCFALLNTGATPVKSNNKLLTTIAYQLNGIRTYALEGSIFVAGSAVQWLRDGLGIIKHAAETGPLADKSDSMQSVYLVPAFVGLGAPYWNPRVRGALFGLTRNTGPAELAHATLESVCYQTYDLWAAMRADWPDASAATIVLRVDGGMTASDWTMQRLADLLDAPVDRPMIQETTALGAAYLAGLNAGVYPEPEKFADNWRLEHRFRPAMSAATRQRKLAGWARAVKGVLASDEGE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: ENO_DESOH
Sequence: MIEIIEVQAREILDSRGNPTVEVDVTLSGGATGRAAVPSGASTGTREALELRDTRKKRYLGKGVEKAVENVNTLIGPVLYGMPADEQFMVDSTMIGLDGTANKSKLGANAILGVSMAVARAAADAYELPLYRYLGGIHAKHLPMPMMNIVNGGAHAANSLDIQEFMIIPVGGKTIAECVRMGAEVFHTLKKLLKAKGFATAVGDEGGFAPDLESNEAAIGFIMEAIKKAGYRPGRDVGIALDAAASEFYEKGKYVLKGEGKKLSSKQMVDYYENLIDKYPILSIEDGLAEQDWDNWVMMTDRLGNTTQIVGDDVFVTNPAIFEKGIREGLANSILIKLNQIGTVSETLQAIDMAKQAGYTTVISHRSGETEDAFIADLAVGVNGGQIKTGSLSRSDRIAKYNQLIRIEEALGAGAVLSNDFTAVVR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: CP52P_CANTR
Sequence: MYQLFCFLAGIIVVYKAAQYYKRRTLVTKFHCKPARISPNKSWLEYLGIASVVHADEMIRKGGLYSEIDGRFKSLDVSTFKSITLGKTTYVTKDIENIRHILSATEMNSWNLGARPIALRPFIGDGIFASEGQSWKHSRIMLRPVFAKEHVKQITSMEPYVQLLIKIIKNHEGEPLEFQTLAHLFTIDYSTDFLLGESCDSLKDFLGEESNSTLDTSLRLAFASQFNKTQQQMTIRFMLGKLAFLMYPKSFQYSIQMQKDFVDVYIDRVVGMSEEELNNHPKSYVLLYQLARQTKNRDILQDELMSILLAGRDTTASLLTFLFFELSHHPEVFNKLKEEIERHFPDVESVTFGTIQRCDYLQWCINETMRLHPSVPFNFRTAANDTVIPRGGGKSCTDPILVHKGEQVLFSFYSVNREEKYFGTNTDKFAPERWSESLRRTEFIPFSAGPRACLGQQLPRVEASYVTIRLLQTFHGLHNASKQYPPNRVVAATMRLTDGCNVCFI
What is the function of this protein?
Together with an NADPH cytochrome P450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.
What are the official names of this protein?
Cytochrome P450 52C1, Alkane-inducible P450-ALK7, CYPLIIC1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane. Membrane; Single-pass membrane protein.
Protein: NUOA_YERPE
Sequence: MRMSTTTEIIAHHWAFAVFLIGAVGLCGLMLLGAYFLGGRAQARAKNVPYESGIDSVGSARMRLSAKFYLVAMFFVIFDVEALYLYAWSISIRESGWIGFIEAAIFILVLLAGLFYLVRIGALDWTPTRSNRRVSKPSTVRYASSHPQDISQELSVAGSQQANESR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOC_BRASO
Sequence: MNQEIMNLFNPTTPAQVFDQIRISIASPEKILSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYKGIICEKCSVEVTLSRVRRERMGHIELAAPVAHIWFLKSLPSRIGLLLDMTLKDLERILYFEYYVVLEPGLTALKDRQLLSEDEYLKAQDEYGQDSFTAMIGAEAIRELLRGLELEKLEQTLRAEMQETDSDIKHKKLAKRLKIVEAFRHSGNKPEWMIMTVVPVIPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLMELRAPDIIIRNEKRMLQEAVDALFDNGRRGRVITGANKRPLKSLADMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELRLHQCGLPKKMALELFKPFIYSRLDAKGLSTTVKQAKKLVEKERPEVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCSAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNILHPANGQPIIVPSQDIVLGLYYVSIMREGMPGQGMTFGNMAELEHALHAKAIHLHSKIKYRWEGMNEEGKIAKRWIETTAGRVMLGNLLPKHPRVTFEVINKLMTKREISGVIDQVYRHCGQKETVIFCDRIMALGFYNAFKAGISFGKDDMVVPAGKWKIVDTTRTLAKDFEQQYNDGLITHGEKYNKVVDAWSKASEEIAKEMMKEISVTKKTATGADADINSIYMMSHSGARGSPAQMRQLAGMRGLMAKPSGEIIETPIISNFKEGLSVLEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDCIITQDDCGTHLGIKMRAIVDAGTLVASLGSRILGRVPCDDVRDPATNAVLVKAGTLMEESHIDAIQQAGVQEVKIRSALTCELVNGICKMCYGRDLARGTPVNHGEAVGVIAAQSIGEPGTQLTMRTFHIGGAAQLNEQSFVESNFEGKVVIRNKAIARNSEGHLIAMVRNMVVTIVDPDGTERATHRIQYGSRMHVDDGDMIKRGQRIAEWDPYTRPILTEAEGTIGFEDLTEGLSISETLDESTGIAKRVVIDWRGTRGGADLRPAIVIKGKDGKVLKLARGGDARYMLSVDAILSVDIGATVKPGDILARISTESAKTRDITGGLPRVAELFEARKPKDAAIIAEIAGTIRFGRDYKNKRRISIEPVDKTEEAREYLIPKGKHIHLQDGDIVEKGDFIVEGNPAPHDILAIKGIEELAAYLVNEIQEVYRLQGVLINDKHIEVIVRQMLQKIEVTDQGDTDMIAGEQVDKIEFDALNAKAQEEGKKPASGNPVLLGITKASLQTRSFFSAASFQETTRVLTEAAVNGKIDPLEGLKENVIVGRLIPAGTGASMARIREVALKRDKLILDEREKQAAIVPSQPEPQPLALPPAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: MTAB_THEMA
Sequence: MKTVRIETFGCKVNQYESEYMAEQLEKAGYVVLPDGNAAYYIVNSCAVTKEVEKKVKRLIKSIRNRNKNAKIILTGCFAQLSPDEAKNLPVDMVLGIDEKKHIVDHINSLNGKQQVVVSEPGRPVYEKVKGSFEDRTRSYIKVEDGCDNTCTYCAIRLARGTRIRSKPLEIFKEEFAEMVMKGYKEIVITGVNLGKYGKDMGSSLAELLKVIEKVPGDYRVRLSSINVEDVNDEIVKAFKRNPRLCPHLHISVQSGSDDVLKRMGRKYKISDFMRVVDKLRSIDPDFSITTDIIVGFPGETDADFQRTLELVEKVEFSRVHIFRFSPRPGTPASRMEGGVPESKKKERLDVLKEKAKDVSIRYRKRIIGKERKVLAEWYVMKGVLSGYDEYYVKHEFVGNRVGEFHSVRVKSLSEEGVISCRADMVEGKVPARG
What is the function of this protein?
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
What are the official names of this protein?
Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB, tRNA-t(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MtaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCES_RAT
Sequence: MESSVKASVDSETESSPGVNETAAASGQRLSEKTRQQADQPKTQDDLVEQNSSYVQDSPSKKRKLDVEIILDEKHSEDDGGASKRSKLERGGGSEDEPSPGGLTERKRKLQPQDALETQTRKFQKLEEGHSSAVAAHYNELQEVGLVKRSQSRIFYLRNFNNWIKSILIGEILEKVRQRKNRDITVLDLGCGKGGDLLKWRKGRISRLVCADIADISMKQCQQRYEDMKCRRDNEYIFSAEFITADCSKELLVEKFHDPEMYFDICSCQFACHYSFESLEQADMMLRNACGRLNPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGNYPLFGCKYDFNLEGVVDVPEFLVYFPLLTEMAKKYNMKLIYKKTFLEFYEEKIKNNENKMLLKRMQALESYPANENSKLASEKAGDYAHAAEYMKNSQVRLPLGTLSKSEWEATSIYLVFAFEKQQ
What is the function of this protein?
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs.  Binds RNA containing 5'-terminal GpppC.
What are the official names of this protein?
mRNA cap guanine-N7 methyltransferase, RG7MT1, mRNA (guanine-N(7))-methyltransferase, mRNA cap methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ERF3A_HUMAN
Sequence: MELSEPIVENGETEMSPEESWEHKEEISEAEPGGGSLGDGRPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
What is the function of this protein?
Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity).  Stimulates the activity of ETF1 (By similarity).  Involved in regulation of mammalian cell growth (PubMed:2511002).  Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019).  Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).
What are the official names of this protein?
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, Eukaryotic peptide chain release factor subunit 3a, eRF3a, G1 to S phase transition protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
Protein: QUEA_EDWI9
Sequence: MRVSDFTFELPDELIARYPQEQRSGCRLLSLDGPTGARQHGVFTDIVDKLNPGDLLVFNNTRVIPARLFGRKASGGKVEVLVERVLDRTRVLAHVRASKAPKPGAGLLLGDNEDIRATMLARHDALFELGFDDPRDVLTILNAAGHMPLPPYIDRPDEEADRELYQTVYSSRPGAVAAPTAGLHFDQPLLDRLRDKGVEMAFVTLHVGAGTFQPVRVESIEDHVMHSEYAEVPQEVVDAVLACKARGNRVIAVGTTSVRSLESAAAANKQALIAPFFDDTQIFIYPGYHYQVIDALITNFHLPESTLIMLVSAFAGYRHTLDAYRDAVVQQYRFFSYGDAMYITRNPQAEQEQVVSA
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBA_NEIMB
Sequence: MSEMLNHVASCRLPTEWGVFTMHGFEEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDALFSRKCDCGPQLEAAMRAVQTEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANLALGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENKRYLQTKADKLGHLMSE
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: URE3_YERAL
Sequence: MQLTPREVEKLMIYTLSDVAFKRKARGLKLNYPEAVSIITVTAMEGARDGKSVEDVMKEASQVLTKDDVMDGVADLIPNVQVEAIFTDGSRLVTVHDPIK
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_ONYPE
Sequence: MQNFDLIKQKIKSLVKQLTKANYQYYNLSNPDLSDQQYDALLKELINLETRYPQFKLPYSPTLKIGGFVEKKFSTIKHKTPMMSLGNVFNLEEIKAFYDRIVKKIPTFSLLTELKIDGVAISLKYQKGILVQALTRGNGIWGEDITKNAQTIKTIPLRLKEDLDLEVRGEIYLSHPAFEKLNAQRKQENKPLFSNPRNAASGTLRQLNSAIVAQRNLSIFVYGISDPYLTKPTQKETLVFLTALGFTTNPHYYCVSNFENLLSVIEKYKTIKEQLTYDTDGIVIKINELAFHSLIGATAKAPRWATAYKFATITSQSIVQNIIFQVGRTGVITPVCKIMPVMVDGSLVSKVVLHNYDYICKKDIRIKDHVIVHKAGSVIPEILEVIKSKRTDLQKPTLMIEKCPACQTILEKQPGEVDYFCLNPNCREQKIQKLIHFVSKNAMDINVLGEQTIIAFFDKNLIAKPSDLYLLKKHKHILQEMPGFGAKKITNILDAIEASKQKGFEDVLFALGIKHIGKKVSQVLAKHFQTIENLQQATPELITQIREIGIKIAQSIQQYFSNSCNLEEVSKLKTLGVSFQSTNPQNPTTQTIFTNKKIVLTGTLQKYSRLQIQQILEQMGAIITNSLSLQNNYLIVGINAGSKLTKAQKLQIPIIEEKELQQIIENSQIKL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: VMP1_MOUSE
Sequence: MAENGKNCDQRRIAMSKDQHNGSLTDPSSVHEKKRRDREERQNIVLWRQPLITLQYFSLETLVVLKEWTSKLWHRQSIVVSFLLLLAALVATYYVEGAHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPEEEGAEGAISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAEAAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIVTFSKHIVEQMVTFIGAVPGIGPSLQKPFQEYLEAQRQKLHHRSEAGTPQGENWLSWMFEKLVVAMVCYFVLSIINSMAQNYAKRIQQRLNSEEKTK
What is the function of this protein?
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (By similarity).  Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (By similarity).  Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:17940279, PubMed:28890335).  Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (By similarity).  In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity).  Modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity).  Plays an essential role in formation of cell junctions (PubMed:31526472).  Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity).  Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity).
What are the official names of this protein?
Vacuole membrane protein 1, NF-E2-inducible protein 2, Protein ni-2.
What is the protein family that this protein belongs to?
Belongs to the VMP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi- pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL21_CAEEL
Sequence: MTNSKGLRRGTRYMFARDFRKHGVEHLSTYYTQYKRGDLVDIKTNGAFQKGMPFKAYHGRTGRIFNVTRGAVGIIVNKRVRGNILPKRINIRIEHIKPSKCRTDFLNRVKSNDEKRKAAKSAGQPVPALKRLPVAPRGAHTVTTQNNEPELLAPLRFEIVA
What are the official names of this protein?
60S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.