Protein: GP_SBVBH
Sequence: MLLNIVLISNLACLAFALPLKEGTRGSRCFLNGELVKTVNTSKVVSECCVKDDISIIKSNAEHYKSGDRLAAVIKYYRLYQVKDWHSCNPIYDDHGSFMILDIDNTGTLIPKMHTCRVECEIALNKDTGEVILNSYRINHYRISGTMHVSGWFKNKIEIPLENTCESIEVTCGLKTLNFHACFHTHKSCTRYFKGSILPELMIESFCTNLELILLVTFILVGSVMMMILTKTYIVYVFIPIFYPFVKLYAYMYNKYFKLCKNCLLAVHPFTNCPSTCICGMIYTTTESLKLHRMCNNCSGYKALPKTRKLCKSKISNIVLCVITSLIFFSFITPISSQCIDIEKLPDEYITCKRELANIKSLTIDDTYSFIYSCTCIIVLILLKKAAKYILYCNCSFCGMVHERRGLKIMDNFTNKCLSCVCAENKGLTIHRASEKCLFKFESSYNRTGLIIFMLLLVPTIVMTQETSINCKNIQSTQLTIEHLSKCMAFYQNKTSSPVVINEIISDASVDEQELIKSLNLNCNVIDRFISESSVIETQVYYEYIKSQLCPLQVHDIFTINSASNIQWKALARSFTLGVCNTNPHKHICRCLESMQMCTSTKTDHAREMSIYYDGHPDRFEHDMKIILNIMRYIVPGLGRVLLDQIKQTKDYQALRHIQGKLSPKSQSNLQLKGFLEFVDFILGANVTIEKTPQTLTTLSLIKGAHRNLDQKDPGPTPILVCKSPQKVVCYSPRGVTHPGDYISCKSKMYKWPSLGVYKHNRDQQQACSSDTHCLEMFEPAERTITTKICKVSDMTYSESPYSTGIPSCNVKRFGSCNVRGHQWQIAECSNGLFYYVSAKAHSKTNDITLYCLSANCLDLRYAFRSSSCSDIVWDTSYRNKLTPKSINHPDIENYIAALQSDIANDLTMHYFKPLKNLPAIIPQYKTMTLNGDKVSNGIRNSYIESHIPAINGLSAGINIAMPNGESLFSIIIYVRRVINKASYRFLYETGPTIGINAKHEEVCTGKCPSPIPHQDGWVTFSKERSSNWGCEEWGCLAINDGCLYGSCQDIIRPEYKIYKKSSIEQKDVEVCITMAHESFCSTVDVLQPLISDRIQLDIQTIQMDSMPNIIAVKNGKVYVGDINDLGSTAKKCGSVQLYSEGIIGSGTPKFDYVCHAFNRKDVILRRCFDNSYQSCLLLEQDNTLTIASTSHMEVHKKVSSVGTINYKIMLGDFDYNAYSTQATVTIDEIRCGGCYGCPEGMACALKLSTNTIGSCSIKSNCDTYIKIIAVDPMQSEYSIKLNCPLATETVSVSVCSASAYTKPSISKNQPKIVLNSLDETSYIEQHDKKCSTWLCRVYKEGISVIFQPLFGNLSFYWRLTIYIIISLIMLILFLYILIPLCKRLKGLLEYNERIYQMENKFK
What is the function of this protein?
Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion (By similarity).  The spikes at the surface of the virion are formed by an N-terminal extension of glycoprotein C (PubMed:30787296).  Glycoprotein N and glycoprotein C are able to attach the virion to host cell receptors (By similarity).  This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity).  Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (By similarity).  Exposure to potassium is necessary for the conformational change leading to fusion (By similarity).
What are the official names of this protein?
Envelopment polyprotein, M polyprotein.
What is the protein family that this protein belongs to?
Belongs to the nairovirus envelope glycoprotein family.
What are the subcellular locations of this protein?
[Glycoprotein C]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of Glycoprotein C and Glycoprotein N results in efficient transport of Glycoprotein C to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs (By similarity). SUBCELLULAR LOCATION: [Glycoprotein N]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=Glycoprotein N is retained in the Golgi complex through a Golgi retention signal, which resides in the Glycoprotein N transmembrane region. SUBCELLULAR LOCATION: [Non-structural protein M]: Host Golgi apparatus membrane; Multi-pass membrane protein.