PharMolix/UniProtQA huggingface dataset:
Protein: CMGA_HUMAN
Sequence: MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
What is the function of this protein?
Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway.  This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
What are the official names of this protein?
Chromogranin-A, CgA, Pituitary secretory protein I, SP-I.
What is the protein family that this protein belongs to?
Belongs to the chromogranin/secretogranin protein family.
What are the subcellular locations of this protein?
[Serpinin]: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Pyroglutaminated serpinin localizes to secretory vesicle. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules.
Protein: CET4_TOBAC
Sequence: MGSKMSDPLVIGRVIGEVVDYFTPSVKMSVTYNSSKHVYNGHELFPSSVTSKPRVEVHGGDLRSFFTLIMIDPDVPGPSDPYLREHLHWIVTDIPGTTDCSFGREIVGYEMPRPNIGIHRFVFLLFKQKKRQTLLSAPLSRDRFNTRKFSEENELGSPVAAAFFNCQRETAARRR
What is the function of this protein?
May form complexes with phosphorylated ligands by interfering with kinases and their effectors.
What are the official names of this protein?
CEN-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylethanolamine-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNMP1_PLUXY
Sequence: MKLPKHLKFAAGAGGAFLFGILFGWVMFPAILKGQLKKEMALSKKTDVRKMWETIPFALNFKVYLYNYTNPEEVQKGGVPIIKEVGPYHFDEWKEKVEIEDHEEDDTITYKKRDTFYFNQEKSGPGLTGEEVITMPHVFMLAMATVVSREKPAMMNMIGKAINGIFDNPADVFIRVKALDIMFRGTMINCARTEFAPKAVCTALKKEAVNGLVMEPNNQFRFSLFGSRNGTIDPHVVTVKRGIKNVMDVGQVVAIDGKPQQDVWRDHCNEYQGTDGTVFPPFLTEHDRLQSFSGDLCRSFKPWYQKKSFYRGITTHRYIANIGDFANDPELNCFCDGPCPPKGLMDLMKCMKAPMYASMPHFLDSDPELLKNVKGLNPDVNEHGIEIDFEPISGTPMVANQRVQFNMQLLKHDKVELLNNLPDTIVPLFWIDEGLALNKTFVNMLKFQLFYPKKAVGVIKWLLVTFGGFGLIGCTIYHYKDRIMSFASSPGSAAVTKVKPEEVEQKDVSVIGQPQEPAKINM
What is the function of this protein?
Plays an olfactory role that is not restricted to pheromone sensitivity.
What are the official names of this protein?
Sensory neuron membrane protein 1.
What is the protein family that this protein belongs to?
Belongs to the CD36 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THII_SALAR
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILAGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALAQYREQLEGKTFCVRVKRRGKHEFSSIEVERYVGGGLNQHIESARVKLANPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKVDDGQMGVVLKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAIKAKIEAEEENFDFSILDKVVEEANNVDIREIAQQTQQEVVEVETVSGFGANDVILDIRSIDEQDDKPLKVEGIDVVSLPFYKLSTKFGDLDQSKTWLLWCERGVMSRLQALYLREQGFANVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YFCZ_ECOLI
Sequence: MSKCSADETPVCCCMDVGTIMDNSDCTASYSRVFANRAEAEQTLAALTEKARSVESEPCKITPTFTEESDGVRLDIDFTFACEAEMLIFQLGLR
What are the official names of this protein?
UPF0381 protein YfcZ.
What is the protein family that this protein belongs to?
Belongs to the UPF0381 family.
Protein: HLDE_PROMH
Sequence: MKVTLPDFNKANVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGANSRLVGLTGIDEAAKALSNTLSQVNVRCDFVSIATHPTITKLRVLSRNQQLIRLDFEEGFSNVSPEPIYERIQQALPSMGALILSDYAKGALSHVQQMIQLAKKAGVPVLIDPKGSDFERYRGATLLTPNMSEFEQVVGVCHTDDELVEKGTQLVKDLALDALLITRSERGMSLLQANEAPLHLPTQAQEVYDVTGAGDTVIGVLATALAAGKPLAEACFLANAAAGVVVGKLGTSTVSPIELENAIRGRADNGFGIMEESQLKQAVALARQRGERIVMTNGCFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGESRPVNPLEQRMTVLGALGAVDWVVAFEEDTPQRLIASVLPDILVKGGDYKPEDIAGSKEVWAAGGEVKVLNFEDGISTTNIINAIKKK
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: IF12_BURP1
Sequence: MAKDDVIQMQGEVIENLPNATFRVKLENGHVVLGHISGKMRMHYIRILPGDKVTVELTPYDLSRARIVFRAK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 2.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_XANCP
Sequence: MSAASPLRWQLIEHAPLRALNTFHVDATARWLLNIHAPEALPDALAAPQIAGQPLLVLGSGSNVLLAGDPPGCVLCFDNRDITIIAHHADHAIVRAGAGVNWHGLVMYSLQQGLSGLENLALIPGTVGACPIQNIGAYGAQVSDFIHVVEAYDRGTEQFVRLNPAECAFGYRDSVFKQQPDRYLIVAVEFNLPLLHELRLDYAGIRDELARMGAELAGAADVAQAVINIRQRKLPDPEVLGNAGSFFKNPLLPSEQIAALQASFADMPVFPGEQPGQGKLSAAWLIEQCGWKGKREGDAGISEAHALVLVNHGSASGAQLLAFARQVAESVRERYSVILEPEPRVIGAHW
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VOME_MOUSE
Sequence: MWVLQALAIMLSIQAGTLDLVETPPVVGNLPVAMPVPLNLPVGGLSPPVLKGPVNHQMLPPKRPVPPPKGGKCAPAARYFLSSDKLHDYLMSTLPPQIEDMVKCDEVNLEGMLADVLNTVESSDLLSLLDGISLLKGGEGGGLGIGGLLGNEGNGDSSKPSSGSKATGGLGQLIPGGIPGTEALGGLLNLGGDKSSGKGLLNGDGLSKIKKPLEDAVENVSGIKDAIQEKVNEVVPDGVKEPLNDVLKMDIKDTLLELKVGQVTLDDMEINMEANGMQVLSMLTATIDGKGVLGPVISLLQFEAKMDVMTTIAVASNNTQCVNLDAQDTHMHVKEMKIQLVETVTGKVPLPVPLPLDQIIPAIVTAKINENLEKSNSCAIVLNDFNNCKNNTGLFSYQVNTARISPKGLVILYCAKANIGNKTVPVPGGRLPPDPKNASIAVTISSTTLKTLVKEVAKNSSVQMDGLEAQITHIAFASQENNTLRVVYKVDITKNGEHFATGETKLFISHGSKISNSTLIPDVKLIRSEHSVVPPEAKEEVEGILSEVGKVAWSNFNETYKKMNIPVGVSSHTLKNSDVKLMKSIDLQAAS
What are the official names of this protein?
Vomeromodulin, BPI fold-containing family B member 9A.
What are the subcellular locations of this protein?
Secreted.
Protein: AROK_SALPK
Sequence: MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADVGWVFDVEGEDGFRNREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQVEAPPREVLEALANERNPLYEEIADVTIRTDDQSAKVVANQIIHMLESN
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 1, SK 1.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIGA_STAAN
Sequence: MSDNTVKIKKQTIDPTLTLEDVKKQLIEKGKKEGHLSHEEIAEKLQNFDIDSDQMDDFFDQLNDNDISLVNEKDSSDTDEKLNPSDLSAPPGVKINDPVRMYLKEIGRVNLLSAQEEIELAKRIEQGDEVAKSRLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNMGLIKAVEKFDFNKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVQRQLLQDLGRDPAPEEIGEEMDLPAEKVREVLKIAQEPVSLETPIGEEDDSHLGDFIEDQEAQSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFMD
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_VIBVY
Sequence: MLQPTLTSWVILAGGQASRMGGKDKGLIALNNKPLIEYVIDRLTPQTSNILINANRNQDDYQQYGPVFGDHFQNFPGPMGGIHAGLLHASTDWVGFVPCDCPRINEDLVERFCRAVTDETDILVAHDGDHQQPVFTLYHKRVLPKLTAFLERGDRKIILLYKECHTQYVDFSDSPDCFVNLNTPEELTQFGQLES
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAT1_MESAU
Sequence: MAKFKIRPATASDCSDILRLIKELAKYEYMEDQVMLTEKDLLEDGFGEHPFYHCLIAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGFGIGSEILKNLSQVAMKCRCSSMHFLVAEWNEPSINFYKRRAASDLSSEEGWRLFKIDKEYLLKMAAEE
What is the function of this protein?
Enzyme which catalyzes the acetylation of polyamines.  Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine.  This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines.  Also involved in the regulation of polyamine transport out of cells.  Also acts on 1,3-diaminopropane and 1,5-diaminopentane.
What are the official names of this protein?
Diamine acetyltransferase 1, Polyamine N-acetyltransferase 1, Putrescine acetyltransferase, Spermidine/spermine N(1)-acetyltransferase 1, SSAT, SSAT-1.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ELOV6_MOUSE
Sequence: MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMLYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVINYLVFNWMQHDNDQCYSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKVKKATKAE
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.  This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.  Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs.  Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree.  May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
What are the official names of this protein?
Elongation of very long chain fatty acids protein 6, 3-keto acyl-CoA synthase Elovl6, ELOVL fatty acid elongase 6, ELOVL FA elongase 6, Fatty acyl-CoA elongase, Long chain fatty acid elongase, Myelin-associated SUR4 protein, Very long chain 3-ketoacyl-CoA synthase 6, Very long chain 3-oxoacyl-CoA synthase 6.
What is the protein family that this protein belongs to?
Belongs to the ELO family. ELOVL6 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: THS_METJA
Sequence: MAMAGAPIVVLPQNVKRYVGRDAQRMNILAGRIIAETVRTTLGPKGMDKMLVDELGDIVVTNDGVTILKEMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVIAGELLRKAEELLDQNIHPSVIINGYEMARNKAVEELKSIAKEVKPEDTEMLKKIAMTSITGKGAEKAREQLAEIVVEAVRAVVDEETGKVDKDLIKVEKKEGAPIEETKLIRGVVIDKERVNPQMPKKVENAKIALLNCPIEVKETETDAEIRITDPAKLMEFIEQEEKMIKDMVEKIAATGANVVFCQKGIDDLAQHYLAKKGILAVRRVKKSDMEKLAKATGARIVTKIDDLTPEDLGEAGLVEERKVAGDAMIFVEQCKHPKAVTILARGSTEHVVEEVARAIDDAIGVVKCALEEGKIVAGGGATEIELAKRLRKFAESVAGREQLAVKAFADALEVIPRTLAENSGLDPIDMLVKLRAAHEKEGGEVYGLDVFEGEVVDMLEKGVVEPLKVKTQAIDSATEASVMLLRIDDVIAAEKVKGDEKGGEGGDMGGDEF
What is the function of this protein?
Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
What are the official names of this protein?
Thermosome subunit, Chaperonin subunit.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
Protein: DTD_FRATF
Sequence: MLSIIQRVNCAKVVVDNQKVADINKGILALVCVEKEDTQQNFEKMADKIIKYRIFEDDAGKMNLSLVDIDAEIILVPQFTLAADTKKGNRPSFSSGCPPEIAKEKFKEFENIFRRKYNKVQTGIFGADMKVFLTNDGPVTFSFKI
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAMA_SALAR
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGDTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTLSDIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAKIQQINIVGNHAFSTEELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYITVNITEGDQYKLSGVEVSGNLAGHSAEIENLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSQPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDSVLRREMRQMEGAWLGSDLVDQGKERLNRLGYFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYSVGINGTKNDYQTYSELSVTNPYFTVDGVSLGGRIFYNDFQADDADLSDYTNKSYGSDVTLGFPINEYNTLRAGVGYVHNSLSNMEPQVAMWRYLYSMGEHPNTDDQNNSFKTDDFTFNYGWTYNKLDRGFFPTEGTRINLNGKVTIPGSDNEYYKATLDTATYVPIDDDHKWVILGRTRFGYGDGFGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYFPHAASNYDPDDDYECATQDGAKDMCKSDDAVGGNAMAVASLEFITPTPFISEKYANSVRTSFFWDMGTVWDTNWDSSQYSGYPDYSDPSNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: Y731_STAAW
Sequence: MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGRLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
What are the official names of this protein?
Epimerase family protein MW0731.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
Protein: HEM1_PAEAT
Sequence: MVLFSLVATHADIDLETVAQLSNGSSELASAALTDSSVVSGAVVLATCNRYEVYGETANGADLEAARSALVSQISELSGLNEQLVSRSFATHTGPDVTRHLFAVSAGLDSAVVGEREIAGQVRRALITAQQEGTASSGLVRLFQAASKTAKDVGAQTALGSRGLSIVSVALDLATDLAENDDWTTKKVVVFGTGAYAGATMSLLRERGCTDISVYSSSGRAEGFVATRGGTALDADTLPAAVAAADVMIGCSGSDNRVEAADLARVRANSGKPLIAIDLALTHDFDPAVGELDGVELLTLESVRLAAPQEQAESLSQASAIVNGAATSFESEREARSVDTAIVALRRHTMNVLDAEMEKVRARHGCTAAAEEVEFALRRMVKQLLHIPTVRARELAANGQQDDYVAALEALYGIQVEQPQAAAPASECPVDHEQLRSESA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: MAO1_ECO45
Sequence: MEPKTKKQRSLYIPYAGPVLLEFPLLNKGSAFSMEERRNFNLLGLLPEVVETIEEQAERAWIQYQGFKTEIDKHIYLRNIQDTNETLFYRLVNNHLDEMMPVIYTPTVGAACERFSEIYRRSRGVFISYQNRHNMDDILQNVPNHNIKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNQQLLNDPLYMGWRNPRITDDEYYEFVDEFIQAVKQRWPDVLLQFEDFAQKNAMPLLNRYRNEICSFNDDIQGTAAVTVGTLIAASRAAGGQLSEKKIVFLGAGSAGCGIAEMIIAQTQREGLSEEAARQKVFMVDRFGLLTDKMPNLLPFQTKLVQKRENLSDWDTDSDVLSLLDVVRNVKPDILIGVSGQTGLFTEEIIREMHKHCPRPIVMPLSNPTSRVEATPQDIIAWTEGNALVATGSPFNPVVWKDKIYPIAQCNNAFIFPGIGLGVIASGASRITDEMLMSASETLAQYSPLVLNGEGLVLPELKDIQKVSRAIAFAVGKMAQQQGVAVKTSAEALQQAIDDNFWHAEYRDYRRTSI
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: INVSA_XENLA
Sequence: MSSPPQGSSLASPVQAAAVTGDKTTLLKLIASSPEVIDQEDQLGRTPLMYSVLGDRRSCAEALLKHGAQVNHPDRSGRTALHLAAQTGNHRLLKLLLSRKADCTHRDLRDITAVHLSTRHQDTRCLALILKYTPPGQVDAQDQRKQTALHWSAYYNRPRHVRLLVRHGSNIGIPDTEGKIPLHWAAGHKDPEAALTVRCLLEAAPTESLLNWQDYEGRTPLHLAVGDGNQEVVRLLTSYRGCNVAPYDNLFRTPLHWAALLGYTPIAHLLLETNNSPNIPSDSQGATPLHYAAQGNCPDTVRVLLSHISVRDEADLEGRTAFMWAAGKGSDEVVRTMLELDPELEVNRTDKYGGTALHAASLSGQITTVRILLENRVQVDAVDVMKHTALFRACEMGHREVISTLIKGGAKVHLVDKDGRSPLHWAALGGNANVCQILIENNINPDAQDYEGRTPLQCAAYGGYIGCMEVLMENKADPNIQDKNGRTALHWSCNNGYLDAVKLLLGYSAFPNQMENTEERYTPLDYALLGGHQEVIQFMLEHGALSIAAIQDIAASKIQAVYKGHKVRRAFQERKNLLMKHEQLRKGAAAKKREGENRQKGKVGQTEGKQKDENHVMRQDKSNEHIQNEVMREWYGEETGRAEDRKEEHQEENQNIEPKQLKHSKHMEQNSKSIAKNQKRAGHIQSSPIEHVHTNSIQTRMSPSRTSISHSSPLGNETPKNMYWDDNPTQNNTQPRRTSRPQIESPNIIVHRIEDLVQKESRRKSHREERKGSHRQRASSHHRLQASERETAGSVIHGEVEFKKKETKKGRRTAAGTSKIRASGEAGRLSQSEKEFSSTGIQGRVDCITSPESCETPSRVCRERKMISAKSGQRPLTETQSPEKACQGSSALKPSLTSHTKQTAIASKCLDSTPSYIGFGEAIKPLTPMGILREGSFSSKWQNIDIELIPLEARLQLVEKEKARKQLFQRKKHAATVIQKAWRTYCIRKSSRKTRHSHLRNNPRAMV
What is the function of this protein?
Required for normal renal development and establishment of left-right axis.  Probably acts as a molecular switch between different Wnt signaling pathways.  Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome.  This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity).  Plays a central role in convergent extension movements in gastrulating embryos, a processus regulated by Wnt signaling.
What are the official names of this protein?
Inversin-A.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Associates with the cytoskeleton.
Protein: RIMO_SALTY
Sequence: MSNVTHQPKIGFVSLGCPKNLVDSERILTELRTEGYDVVPRYDDADMVIVNTCGFIDSAVQESLEAIGEALNENGKVIVTGCLGAKEDQIREVHPKVLEITGPHSYEQVLQHVHHYVPKPKHNPFLSLVPEQGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPIGDVLSEAKRLVDAGVKEILVISQDTSAYGVDVKHRTGFHNGEPVKTSMVSLCEQLSKLGVWTRLHYVYPYPHVDDVIPLMAEGKILPYLDIPLQHASPRILKLMKRPGSVDRQLARIKQWREICPELTLRSTFIVGFPGETEEDFQMLLDFLKEARLDRVGCFKYSPVEGAGANELPDQVPEEVKEERWNRFMQLQQQISAERLQEKVGREILVIVDEVDEEGAIGRSMADAPEIDGAVYLNGETNVKPGDIVRVKVENADEYDLWGSRV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_CHLPM
Sequence: MIYQMQMPAKIEVDETTHTDYFGRFVAQPLERGYGVTLGNMMRRVLLASLPGTAITGIKVDGVFHEFSAIEGVREDVPEIVLNLKKVRFRSTCKRSCKTTLTITGPKDFTAGDIVAMEGEFDVLNKDLHIATVNEGSTLNIDVFVGRGRGYTPAEDNRPESMPIGYIAIDAIYTPIRNVKVAVENTRVGQRTDYEKMVLDVETDGSITPDDSISLAGRIINEHVAFFADFSPTEEEFTEEEFKQQDDEFEAMRKLLNTKIEDLDLSVRSHNCLRLAEIDSIGDLVSRKEDELLNYKNFGKKSLTELKEQLEKFELKFGMDITKYQMKG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: LIFO_BURPL
Sequence: MAQADRPARGGLAARPMRGASFALAGLVACAACAAVVLWLRPAAPSPAPAGAVAGGPAAGVPAAASGAAEAAMPLPAALPGALAGSHAPRLPLAAGGRLARTRAVREFFDYCLTAQGELTPAALDALVRREIAAQLDGSPAQAEALGVWRRYRAYFDALAQLPGDGAVLGDKLDPAAMQLALDQRAALADRTLGEWAEPFFGDEQRRQRHDLERIRIANDTTLSPEQKAARLAALDAQLTPDERAQQAALHAQQDAVTKIADLQKAGATPDQMRAQIAQTLGPEAAARAAQMQQDDEAWQTRYQAYAAERDRIAAQGLAPQDRDARIAQLRQQTFTAPGEAIRAASLDRGAGG
What is the function of this protein?
Involved in the folding of the extracellular lipase (lip) during its passage through the periplasm.
What are the official names of this protein?
Lipase-specific foldase, Lif, Lipase activator protein, Lipase chaperone, Lipase helper protein, Lipase modulator.
What is the protein family that this protein belongs to?
Belongs to the lipase chaperone family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: BIOY_RHIEC
Sequence: MSTRDLVLTALFAAIIVALGLLPPISLGFIPVPITAQSLGVMMAGVVLGARRGAIAVLIVLLLVAIGLPVLSGGRGGLAIFASPTAGFLVGWIFGAFVTGYLSERLVNHGQSGLVQTVSFFLAAMIGGIVVLYAFGITYLATVAGLGFTKAFVGSMAFIPGDVIKAVVAALLGRAVMVGYPLLPARA
What is the function of this protein?
Involved in biotin uptake.
What are the official names of this protein?
Biotin transporter BioY, Biotin ECF transporter S component BioY.
What is the protein family that this protein belongs to?
Belongs to the BioY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COA5_XENLA
Sequence: MPKYYEEKEEEKHPCGGVKEDLKNCLLQSDCVLQEGKSPKECLKEGYCKALQVTFFECKRSILDNRARFRGRKGY
What is the function of this protein?
Involved in an early step of the mitochondrial complex IV assembly process.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 5.
What is the protein family that this protein belongs to?
Belongs to the PET191 family.
Protein: PUR5_ALKCK
Sequence: MSNAYKEAGVDIEAGYEAVNRMKRHVERTARKGVLGGLGGFGGNFDLSTLGLKEPVLVSGTDGVGTKLMIAFMANKHDTIGQDAVAMCVNDIVVQGAEPLYFLDYLACGKAVPEKIEAIVKGVADGCEIAGCALIGGETAEMPGMYEEDEYDLAGFSVGAVEKKDLLTGEHIQAGDVLIGLPSSGLHSNGFSLVRKVLLQDAGLTLQTECATLGKTLGEELLTPTKIYVKPLLACLKQGLLAGAAHITGGGFYENIPRMLPKGVGIHIDYGSWPIPPIFSLIQEKGGLSEQDLFHTFNMGIGMVLAVPEDKHQQALATLEANGEDAYIIGRVTPTEGTVIGGIGA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.