PharMolix/UniProtQA huggingface dataset:
Protein: COX3_PANPA
Sequence: MAHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFYSTTLLTLGLLTNTLTMYQWWRDVMRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICLIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MZM1_NEUCR
Sequence: MSALQAYRHLMRAARVAFDGDNRTLTAAYESIRRGFRENQNVPANDPTIAPAIAHAEEVASFLRSNVVQGRKDGETYKLRIHQDTERGDNDTIKLGNQTIKIGGEQKCCSA
What is the function of this protein?
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex.  Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.  Modulates the mitochondrial matrix zinc pool (By similarity).
What are the official names of this protein?
Mitochondrial zinc maintenance protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. MZM1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: YGIC_ECOL6
Sequence: MERVSITERPDWREKAHEYGFNFHTMYGEPYWCEDAYYKLTLAQVEKLEEVTAELHQMCLKVVEKVIASDELMTKFRIPKHTWSFVRQSWLTHQPSLYSRLDLAWDGTGEPKLLENNADTPTSLYEAAFFQWIWLEDQLNAGNLPEGSDQFNSLQEKLIDRFVELREQYGFQLLHLTCCRDTVEDRGTIQYLQDCATEAEIATEFLYIDDIGLGEKGQFTDLQDQVISNLFKLYPWEFMLREMFSTKLEDAGVRWLEPAWKSIISNKALLPLLWEMFPNHPNLLPAYFAEDDHPQMEKYVVKPIFSREGANVSIIENGKTIEAAEGPYGEEGMIVQQFHPLPKFGDSYMLIGSWLVNDQPAGIGIREDRALITQDMSRFYPHIFVE
What is the function of this protein?
May be a ligase forming an amide bond.  Shows ATPase activity (By similarity).
What are the official names of this protein?
Putative acid--amine ligase YgiC.
What is the protein family that this protein belongs to?
Belongs to the glutathionylspermidine synthase preATP-grasp family.
Protein: RIMK_PSEPG
Sequence: MKIAVLSRNPRLYSTRRLVEAGIQRGHEMVVIDTLRAYMNIASHKPQIHYRGKPLEGFDAVIPRIGASVTFYGCAVLRQFEMMGVYPLNESVAIARSRDKLRSLQLLSRRGIGLPITGFAHSPDDIPDLIQMVNGAPLVIKVLEGTQGIGVVLCETTQAAESVIEAFMGLKQNIMVQEYIKEAGGADIRCFVVGDKVIASMKRQAKPGEFRSNLHRGGVASLIKITPEERITAIRAAKVMGLSVAGVDILRSNHGPLVMEVNSSPGLEGIEVTTGKNVAGMIIEHLEKNGGPNQTRTKGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: IAAE_HORVU
Sequence: MAFKYQLLLSAAVMLAILVATATSFGDSCAPGDALPHNPLRACRTYVVSQICHQGPRLLTSDMKRRCCDELSAIPAYCRCEALRIIMQGVVTWQGAFEGAYFKDSPNCPRERQTSYAANLVTPQECNLGTIHGSAYCPELQPGYGVVL
What is the function of this protein?
Inhibits trypsin in vitro.  Probably plays a protective role through inhibition of insect midgut proteases.
What are the official names of this protein?
Trypsin inhibitor CMe, Alpha-amylase/trypsin inhibitor, BTI-CMe1, BTI-CMe2.1, BTI-CMe3.1, Chloroform/methanol-soluble protein CMe.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GATA_GEOTN
Sequence: MSLFDHTVSELHTLLQKKEVSISDLVDESYRRIGEVEEKVQAFLTLNEEQARAKAKELDDKLAKGEETNPLFGLPIGIKDNIVTKGLRTTCASKILYNFDPIYDATVMERLNAAGAITIGKLNMDEFAMGSSTENSGFQLTRNPWDLERVPGGSSGGSAAAVAAGEVPFSLGSDTGGSIRQPAAFCGVVGLKPTYGRVSRFGLVAFASSLDQIGPITRTVEDNAYLLQVIAGVDPMDSTSANIDVPNYVEALTGDIKGLKIAVPKEYLGEGVAEEVRQSVLAALSVLEKLGATWEEVSLPHSKYALATYYLLASSEASANLARFDGVRYGYRTDNAKNLIDMYKQTRSEGFGSEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKRDFENVFEQYDVIIGPTTPTPAFKIGEKTSDPLTMYMNDILTIPVNLAGVPAISVPCGFVDGLPVGLQIIGKHFDESTVYRVAHAFEQATDYHKQKPVL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: CDC25_YEAST
Sequence: MSDTNTSIPNTSSAREAGNASQTPSISSSSNTSTTTNTESSSASLSSSPSTSELTSIRPIGIVVAAYDFNYPIKKDSSSQLLSVQQGETIYILNKNSSGWWDGLVIDDSNGKVNRGWFPQNFGRPLRDSHLRKHSHPMKKYSSSKSSRRSSLNSLGNSAYLHVPRNPSKSRRGSSTLSASLSNAHNAETSSGHNNTVSMNNSPFSAPNDASHITPQSSNFNSNASLSQDMTKSADGSSEMNTNAIMNNNETNLQTSGEKAGPPLVAEETIKILPLEEIEMIINGIRSNIASTWSPIPLITKTSDYKLVYYNKDLDIYCSELPLISNSIMESDDICDSEPKFPPNDHLVNLYTRDLRKNANIEDSSTRSKQSESEQNRSSLLMEKQDSKETDGNNNSINDDDNNNENNKNEFNEAGPSSLNSLSAPDLTQNIQSRVVAPSRSSILAKSDIFYHYSRDIKLWTELQDLTVYYTKTAHKMFLKENRLNFTKYFDLISDSIVFTQLGCRLMQHEIKAKSCSKEIKKIFKGLISSLSRISINSHLYFDSAFHRKKMDTMNDKDNDNQENNCSRTEGDDGKIEVDSVHDLVSVPLSGKRNVSTSTTDTLTPMRSSFSTVNENDMENFSVLGPRNSVNSVVTPRTSIQNSTLEDFSPSNKNFKSAKSIYEMVDVEFSKFLRHVQLLYFVLQSSVFSDDNTLPQLLPRFFKGSFSGGSWTNPFSTFITDEFGNATKNKAVTSNEVTASSSKNSSISRIPPKMADAIASASGYSANSETNSQIDLKASSAASGSVFTPFNRPSHNRTFSRARVSKRKKKYPLTVDTLNTMKKKSSQIFEKLNNATGEHLKIISKPKSRIRNLEINSSTYEQINQNVLLLEILENLDLSIFINLKNLIKTPSILLDLESEEFLVHAMSSVSSVLTEFFDIKQAFHDIVIRLIMTTQQTTLDDPYLFSSMRSNFPVGHHEPFKNISNTPLVKGPFHKKNEQLALSLFHVLVSQDVEFNNLEFLNNSDDFKDACEKYVEISNLACIIVDQLIEERENLLNYAARMMKNNLTAELLKGEQEKWFDIYSEDYSDDDSENDEAIIDDELGSEDYIERKAANIEKNLPWFLTSDYETSLVYDSRGKIRGGTKEALIEHLTSHELVDAAFNVTMLITFRSILTTREFFYALIYRYNLYPPEGLSYDDYNIWIEKKSNPIKCRVVNIMRTFLTQYWTRNYYEPGIPLILNFAKMVVSEKIPGAEDLLQKINEKLINENEKEPVDPKQQDSVSAVVQTTKRDNKSPIHMSSSSLPSSASSAFFRLKKLKLLDIDPYTYATQLTVLEHDLYLRITMFECLDRAWGTKYCNMGGSPNITKFIANANTLTNFVSHTIVKQADVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESKDLLKNLNNLMDSKRNFVKYRELLRSVTDVACVPFFGVYLSDLTFTFVGNPDFLHNSTNIINFSKRTKIANIVEEIISFKRFHYKLKRLDDIQTVIEASLENVPHIEKQYQLSLQVEPRSGNTKGSTHASSASGTKTAKFLSEFTDDKNGNFLKLGKKKPPSRLFR
What is the function of this protein?
Promotes the exchange of Ras-bound GDP by GTP.  This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.
What are the official names of this protein?
Cell division control protein 25.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: BABA2_XENLA
Sequence: MSPEVTLNRISPALSPFISSVVRNGKVGLDSTNCLRITDLKSGCTSLTPGPSCDRFKLHIPYAGETLKWDIIFNASYPELPPDFIFGEDAEFLPDPSALHNLSEWNPSDPECLLLVVKELVQQYHQYQCSRLSESSRLMFEYQTLQEEPQYGLNMEIYAGKKNNWTGEFSARFLLKMPVDFSNIPIYLLKDSNEDPGEDVALLSVSFEDAEATQVFPKLFLSPRIEHALGGSSALHIPVFPSGSCLIDYVPQVCQLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLSWKDFCFLVHTVDLPLYFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFRSFVPQFQEAAFANGKL
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the brca1-bard1 heterodimer.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1.  The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.  May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins.  May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
What are the official names of this protein?
BRISC and BRCA1-A complex member 2, BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, Brain and reproductive organ-expressed protein.
What is the protein family that this protein belongs to?
Belongs to the BABAM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: CALM_PERFV
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
What is the function of this protein?
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding.  Calcium-binding is required for the activation of calmodulin.  Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: Y108_AFV2P
Sequence: MIDEYLKKNGIKFTQRQYNDKIKYTLLTPVASKISDVLKTVTEMMKFVDNNEYVVVPIAKAGDYMVELSLSQSSMSWRIAKKMTYIDVTDKDIDVLMNVLQKLKNVKL
What are the official names of this protein?
Uncharacterized protein ORF108.
Protein: GATC_GEOSL
Sequence: MKITRTDVEHVATLARLELTEDEKDRFTGQLDAILAYVEKLNELDTDGIIPTSHAVPVENAFREDEVRPSIGVENALANAPDRVEGFFRVPRVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: DNLJ_STRT2
Sequence: MEKRMKELVDKLNQYAKEYYTEDNPSVSDAEYDKLYRELVTLEAEHPELVQADSPTHRVGGLVLDGFEKYQHEYPLYSLQDAFSREELDAFDKRVKSEFPNADYMAELKIDGLSISLTYVDGILQVGATRGDGSVGENITENVKRISDIPLKLDQPLNITVRGECYLPRAEFERINTQRQENGEAEFANPRNAAAGTLRQLDTKVVAERRLATFFYQEASPTERLTQNDVLNEVAELGFSVNPRRIVTSSMDEIWDFIQAVGQDRDHLAYDIDGVVIKVNSLAIQEELGFTVKAPRWAIAYKFPAEEKEAKLLSVDWQVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYITEKDIRIGDTVIVYKAGDIIPAVLRVVESKRTTQEAMPVPSQCPSCGSGLLHFEDEVALRCINPSCPAQIKEGLIHFASRDAMNISGMGPSVVEKLFKAELVKEVADIYGLNSQDFLQLEGFKEKSAEKLYAAIQASKENSAEKLLYGLGIRHVGAKVSKQLLESFGTIKELASADVQAIAAVDGLGEVIAKSIQRYFAKEEAQVLLKELESYGVNLSYLGQKVADDAILSGKTVVLTGKLEHLKRSEAKAKLEALGAKVTGSVSKKTDLVVAGSDAGSKLEKAQSLGIEVKDEAWLLDL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL191_ARATH
Sequence: MVSLKLQKRLAASVMKCGKGKVWLDPNESSDISMANSRQNIRKLVKDGFIIRKPTKIHSRSRARKMKIAKMKGRHSGYGKRKGTREARLPTKVLWMRRMRVLRRLLKKYRETKKIDKHMYHDMYMRVKGNVFKNKRVLMESIHKSKAEKAREKTLSDQFEAKRAKNKASRERKHARREERLAKGPGGDVAPVAAPAPAATPAPTAAVPKKKSKK
What are the official names of this protein?
60S ribosomal protein L19-1, Protein EMBRYO DEFECTIVE 2386.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL19 family.
Protein: PLYC_ASPFN
Sequence: MRLTPSLISCLSLLHFTSALVAFPGAEGFGANAVGGRQGEVYVVSNLNDSGEGSLRDAVSQPGRIVVFSVGGVIEITDRIVVSKQVTILGQTAPGDGITVYGNGWSFSNADDAIVRYIRIRMGKGGSSGKDAMGIADGKNMIFDHVSVSWGRDETFSINGDVSNVTIQNSIIAQGLETHSCGGLMQTDGGVSLFRNLYIDNKTRNPKVKGVNEFTNNVIYNWGGGGGYIAGGSDGESNVNVIGNYFISGPDTSVTAFTRGNENFHAYVETNYYDSDKDGTLNGSELGVDSTNYGGMDLVTEKYDYPAVASVLSPDDALTYVTKYAGASKVRDSVDTQLVAQVESYGKDGALISDEADMGGAGDLDQGTTPTDTDGDGIPDDAEAELGTDPNTADSMDLDTSGYTFLEVWANSLVPSSYA
What is the function of this protein?
Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.  Favors pectate, the anion, over pectin, the methyl ester (By similarity).
What are the official names of this protein?
Probable pectate lyase C.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPD_PASMU
Sequence: MTTPIAKSTRRIVAVVPAAGIGSRMQMDKPKQYLHIHGKTILEHTLSVLLGYPLIEKIILAVAANDPYISTCPLLTHPKIQLVEGGSSRADSVLNGLNAVKSAVQNSEDFWVMVHDAARPCLTHQDLDKLVQVEDQNGAILAIPATDTIKRALHNQQIHYTEDRSQLWLAQTPQFFPIATLAQALEQALAQGLQVTDEASAMEFAGFRPHLVAGRSDNIKVTRPEDFALAEFYLSRTK
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: HEM3_HALH5
Sequence: MRKIIIGSRRSQLALTQTEWVISKLKEAGAPFDFEIKKIITKGDQILDVTLSKVGGKGLFVKEIEQAMANKEIDIAVHSMKDVPSVLQEGFALGATTTRVDPRDALISNEGYTLAELPAGSIVGTSSLRRSAQILAKRPDLEVKWIRGNIETRLRKLKEEDFDAIILAAAGLERMGWSNEIVTEYLDPDLCVPAVGQGALGIECRADDDEVLEMLKTINDDTTAKTVLAERTFLHRMEGGCQVPIAGYATLTDEGEIELTALVGTPDGEQIFKEILRGKDPVQLGETMAQALMDQGAKEVLEQVKKGLESQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PLSY_BARQU
Sequence: MNESETLLQFYTWSIFLMSYLIGSIPFGLLFTRLAKLGDVRAIGSGNIGATNVLRTGNKKVATLTLLCDILKGTVVVLVIKFLNDPIENSIIISLVGFFAFLGHLFPIWLKFKGGKGVATYLGVCLGYYWPAAIVFIIVWIMFFILTRYSSLSALIAVIITPIFVYFSYPHLYAHCILVMMSIFVIIKHHANIARLLIGKESKIGTQNRDK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TOP1_ARCFU
Sequence: MVMSWLIITEKDNTARRIASILFKDVKTLKKGRVSYYHSPSNDAYVVGLKGHIVELDFPKELNNWTKTPLEKLLQAELVKKVKERTISSILKEIAKKADRVTVATDYDREGELIGVEALEIVKSVNPTVKVDRVRYSAVTEKEIRSAFSKPVKVDFNLANAALARQKIDLIWGATLTRLISVHSGRMGKDFLSVGRVQTPTLRLIVDRELEIQNFKPEKYYEIFAEFEGFIAKHPKRYGSKEEAEKLFAKIGETAKVEEFTRRRMEENRPTPFNTTEFLREASKFMSPHKAMNIAETLYMNGYISYPRTDNTVYPPTINLIEIVSALSSVFPREAQIVLSQDKITPSRGRRETKDHPPIYPTGVAKRGELSKDEWTIYELVVRRFLATLAPKAVWDVRRVVLDSNGVKFVANGRQLVEAGWRDIYIYSKAEETELPLLKKGDVLRILKKRLEEKETKPPGRYSASSLIKMMEKLNLGTKSTRHEIIQKLVSRRYIHGNPFRPSETAFSVINVLKETAETITLPDMTAKLENEMDLIAEGKKREPEVVDESREMLLQILRAIDYRKLSKDLREGVKKDKIVGKCPECGGELVVRQSKAGKRFIGCSNYPDCTFTLPLPQNGTLYITAKQCKEHEIKEVKIRTKKGYWNLGCPYCNYLNWKKENS
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: RPPH_RICTY
Sequence: MKNSSNKYLDLPYRPGVGMMILNADNQIFVGKRIDTKISAWQMPQGGIVPGETPSIAAMREMLEEIGSNKGYIIAESKCWYSYDVPSFLIPKLWNGNFRGQKQRWFLIRFTGNNKDINIHTSNPEFDQWRWTSLDELLSIIIPFKRKLYQAVVKEFESLIQ
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: ASTE_SALDC
Sequence: MDNFLALTLSGTTPRVTQGKSAGFRWRWLGHGLLELTPDAPVDRALILSAGIHGNETAPVEMLDKLLSALFSGSLTLTWRVLVVLGNPQALAAGIRYCHSDMNRMFGGRWQSFAESDETRRARELELSLETFFSSGHARVRWHLDLHTAIRGSHHLRFGVLPQRDRPWETDFLAWLGAAGLEALVFHQAPGGTFTHFSSEHFGALSCALELGKALPFRQNDLTQFNVTSQALSALLSGVETSTSFSPPLRYRVVSQITRHSDKFALYMDAQTLNFTAFAKGTLLAEEGDKRVTVTHDVEYVLFPNPSVACGLRAGLMLERLP
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: GRPE_FRATF
Sequence: MSKQEKSNVEDKSLDIETAAQVETAQESASGALEELSVEEQLERAKDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALKHEVKLEEAIAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIPNPEFEDNTIFDVFQKGYMLNGRIVRAAKVVIVKN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_STRPF
Sequence: MQLTESLGIVLFNRNYREDDKLVKIFTEVAGKQMFFVKHISRSKMSSIIQPLTIADFIFKLNDTGLSYVVDYSNVNTYRYINNDIFRLAYASYVLALADAAIADNESDSHLFTFLKKTLDLMEEGLDYEILTNIFEIQILDRFGISLNFHECAICHRTDLPLDFSHRFSAVLCSEHYYKDNRRNHLDPNVIYLLSRFQKITFDDLRTISLNKDIKKKLRQFIDELYHDYVGIKLKSKTFIDNLVKWGDIMK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RL10_THERP
Sequence: MPTPEKARQIEEISEILRTASLAILTDYRGLSVADMTAFRRRLQEQQANFRVVKNTLTRIAAERTGTEVITPLLEGPTALVYSMGDPVAAAKLTLEFARQSRILSVKGGLLAGRLLSAADVEALATLPPREELLAKVVGGLQAPLYGLVSVLSGPIRGLLYVLQARVRQLGGEEAAEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: DNAK_METTH
Sequence: MAKKEKILGIDLGTSNSAAAVLIGGKPTIIPSAEGASQYGKSFPSCVAFTEDGQMLVGEPARRQAVTNPENTITAIKRSMGTDRKVKVHGKEYTPQEISAFILQKIKKDAEAFLGEEIKKAVITVPAYFDDNQRTATKDAGTIAGLDVVRLVNEPTAASLAYGLDKEDEDMVIMVFDLGGGTLDVTIMEFGGGVFEVRSTSGDTQLGGTDMDNAIMNYLAEEFKMETGIDLMEDDQAVQRLREAAEKAKIELSTTLTTEVNLPYITVAQDGPKHLIKTITRAKLEELVDPIVQKCAGPMEQALRDAGMTREDVDKIILVGGPTRMPIVQKFVEDFIGKPVERGIDPMECVAMGAAIQGGVLAGEIKDLVLLDVTPLSLGIETLGGVFTKLIERNTTIPTRKSQIFSTAADNQTSVDIHVLQGERPMAADNTSLGRFQLVGIPPAPRGVPQIEVTFDIDANGILNVSAKDLGTGKEQAITITAPNKLSEEEIKQKIEEAKKHAEEDRRKQEEIEIRNNADSMIYTAEKTLDELGDKVPAEKKEEVEKQVRELRELIAGDDIQAIKSKTEELTKTVQEIGVSYIPAGSTATSSTAAGR
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.