PharMolix/UniProtQA huggingface dataset:
Protein: THAP1_MACFA
Sequence: MVQPCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKEWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLCTEPHDKKEDLEPQEQLPPPPLPPPVSQVDAAIGLLMPPLQTPVNLSVFCDHNYTVEDTMHQRKRIHQLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQKEKDNVSERGYVILPNDYFEIVEVPA
What is the function of this protein?
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression.  Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1.  Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.  May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
What are the official names of this protein?
THAP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the THAP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, PML body.
Protein: ALG14_RAT
Sequence: MVCVLTLAASAGGLAVLLIVRLWAVLRSHPVTPRQSLGLLIVAGSGGHTAEILRLVGSLSGAYSPRHYVIAESDEMSAKKIHSLELARAQNDSTTEHTEYYLHRIPRSREVRQSWLSSVFTTLYSIWFSFPLVHRIKPDLVLCNGPGTCVPICVSALLLGILGIKKVIIVYVESICRVETLSLSGKILWHLSDYFIVQWPTLKEKYPKSVYLGRIV
What is the function of this protein?
Involved in protein N-glycosylation.  Essential for the second step of the dolichol-linked oligosaccharide pathway.  Anchors the catalytic subunit ALG13 to the ER (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine transferase subunit ALG14 homolog.
What is the protein family that this protein belongs to?
Belongs to the ALG14 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein.
Protein: ELOV3_HUMAN
Sequence: MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIYLVLIAVGQNYMKERKGFNLQGPLILWSFCLAIFSILGAVRMWGIMGTVLLTGGLKQTVCFINFIDNSTVKFWSWVFLLSKVIELGDTAFIILRKRPLIFIHWYHHSTVLVYTSFGYKNKVPAGGWFVTMNFGVHAIMYTYYTLKAANVKPPKMLPMLITSLQILQMFVGAIVSILTYIWRQDQGCHTTMEHLFWSFILYMTYFILFAHFFCQTYIRPKVKAKTKSQ
What is the function of this protein?
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle.  This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle.  Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs.  May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
What are the official names of this protein?
Elongation of very long chain fatty acids protein 3, 3-keto acyl-CoA synthase ELOVL3, Cold-inducible glycoprotein of 30 kDa, ELOVL fatty acid elongase 3, ELOVL FA elongase 3, Very long chain 3-ketoacyl-CoA synthase 3, Very long chain 3-oxoacyl-CoA synthase 3.
What is the protein family that this protein belongs to?
Belongs to the ELO family. ELOVL3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi- pass membrane protein.
Protein: ARGO_YERPN
Sequence: MLAVYLHGFILSAAMILPLGPQNVFVMNQGIKRQHHLMSASLCALSDIILICAGIFGGSALLSRSPLLLALVTWGGVAFLMWYGWGALMAAWRGDGVASSATSVTQGRWRILVTLLAVTWLNPHVYLDTFVVLGSLGGQLLPDIRPWFALGAVTASIVWFFALALLAAWLSPWLNRPVAQRIINLFVGGVMGFIAFQLARQGFGL
What is the function of this protein?
Involved in the export of arginine.  Important to control the intracellular level of arginine and the correct balance between arginine and lysine.
What are the official names of this protein?
Arginine exporter protein ArgO.
What is the protein family that this protein belongs to?
Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COPA_ENTHA
Sequence: MATNTKMETFVITGMTCANCSARIEKELNEQPGVMSATVNLATEKASVKYTDTTTERLIKSVENIGYGAILYDEAHKQKIAEEKQTYLRKMKFDLIFSAILTLPLMLAMIAMMLGSHGPIVSFFHLSLVQLLFALPVQFYVGWRFYKGAYHALKTKAPNMDVLVAIGTSAAFALSIYNGFFPSHSHDLYFESSSMIITLILLGKYLEHTAKSKTGDAIKQMMSLQTKTAQVLRDGKEETIAIDEVMIDDILVIRPGEQVPTDGRIIAGTSALDESMLTGESVPVEKKEKDMVFGGTINTNGLIQIQVSQIGKDTVLAQIIQMVEDAQGSKAPIQQIADKISGIFVPIVLFLALVTLLVTGWLTKDWQLALLHSVSVLVIACPCALGLATPTAIMVGTGVGAHNGILIKGGEALEGAAHLNSIILDKTGTITQGRPEVTDVIGPKEIISLFYSLEHASEHPLGKAIVAYGAKVGAKTQPITDFVAHPGAGISGTINGVHYFAGTRKRLAEMNLSFDEFQEQALELEQAGKTVMFLANEEQVLGMIAVADQIKEDAKQAIEQLQQKGVDVFMVTGDNQRAAQAIGKQVGIDSDHIFAEVLPEEKANYVEKLQKAGKKVGMVGDGINDAPALALADVGIAMGSGTDIAMETADVTLMNSHLTSINQMISLSAATLKKIKQNLFWAFIYNTIGIPFAAFGFLNPIIAGGAMAFSSISVLLNSLSLNRKTIK
What is the function of this protein?
Probably involved in copper import under copper limiting conditions.
What are the official names of this protein?
Probable copper-importing P-type ATPase A.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL32_RHIWR
Sequence: MAVPKRKTSPSRRNMRRSHHALTAEAFQECPNCGELKRPHNLCNACGHYNGREIVSVEA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PYRB_BRUA2
Sequence: MTNQTVSPLFPHRHLLGIKGLSPLDILCLLDLADQEIAVSRQPEKKKSVLRGRTQINLFFEASTRTQSSFELAGKRLGADVMNMSVGNSSVKKGETLIDTAMTLNAMQPDILVIRHASAGAAALLAQKVGCSVVNAGDGAHEHPTQALLDALTIRRAKGQIENLIVAICGDVLHSRVARSNILLLNALGARVRVVAPSTLLPAGMADMSVEVFNSMEEGLKDADVVMMLRLQRERMAGSFVPSVREYFHFYGLDREKLKFAKPDALVMHPGPMNRGVEIASDVADGPQSVIQQQVEMGVAVRMAVMEALLDPRRNPGNGEPA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TPIS_ENDTX
Sequence: MRKPLMAGNWKMNKTVSEAVSFVKALKGAVTGVSNVEILVCPAFTVLYEVNNEIKGSNINLGAQNLFGEAKGAFTGEISTAMIRDTGCSYVIVGHSERRQYFGETDEAVNKKTKAALAADITPIVCVGETLKERENNVTFSVIEKQVRNGLADLTLQQASLTVIAYEPVWAIGTGKTATPDQAQEVHSFIRKIYAQMYEESAEKVRILYGGSVNPGNVSDLMKKSDIDGGLVGGASLEAESFTKLVKYSK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_VIBCH
Sequence: MLQIKSIPAFDDNYIWLIQNRDRDCAVVDPGSAEPVLAYLKQHDLNLKAVLITHHHHDHIGGVAELVHQFPEIHVVGPAQEPIPTLTHPVEDGDQIELFDERFMVLGLPGHTLGHIGYVGDGKLFCGDVLFSAGCGRVFEGTMEQMFSSLNKLLSLPEETQVYSAHEYTAANVAFALAVEPENEQLHIYRDEVSRLRAQNQPTLPTTLGREKWVNPFLRTQEPSVIRSVASQVSTLDPLTIFTALREWKNEF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: KGUA_SULDN
Sequence: MNHKTGAILVLSGPSGAGKSSLIKEVIDDIGECYFSISTTTRPIREGEVDGVHYHFVSESEFKKDIEDEFFLEYAVVHSNYYGTSIKPVKKALKSGKLVIFDIDVQGNATIINRLGDITTSVFISPPTLSELKKRLEARSTDTKDVIERRIEMAKREMQRVSEYDFLIVNDNLQEAAKTLRIIADAARVKIPSNEINDFVRSWEDI
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN675_HUMAN
Sequence: MGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEPLTVKRHEMVNEPPVMCSHFAQEFWPEQNIKDSFEKVTLRRYEKCGNDNFQLKGCKSVDECKLHKGGYNGLNQCLPTMQSKMFQCDKYVKVFNKFSHSDRHKIKHMENKPFKCKECGRSFCMLSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNLTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTHKKIHTGEQPYICEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSSSLTTHKRIHTGEKPYKCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTKHKKIHTGEKLQNWNV
What is the function of this protein?
May be involved in transcriptional regulation.  May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.
What are the official names of this protein?
Zinc finger protein 675, TRAF6-binding zinc finger protein, TRAF6-inhibitory zinc finger protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOZ_ACAM1
Sequence: MSKRPTIDTTHIMRRAEELISASSNRYRITVQVANRAKKRRRRENLEDFEDAGMKSVMQAIIEMSDELTQPEIIGE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: DNLJ1_STRGG
Sequence: MSVVGGRMVAMTNSAAVLADAAAYAAAVEEASLAAAAYYATGESALDDDAYDRLARGIAAYEADHPEEVLADSPTGKVAGGAAVGDVPHTVPMLSLDNVFSAEQFVTWTASLERRIGRPVTAWSVEPKLDGLAVAARYRDGRFERLITRGDGTAGEDVSHAAGAVVGLPERLAEPVTIEVRGEILMTNEQFAQGNAIRTEHGGAPFANPRNGAAGTLRAKDRAYRVETTFFAYGALPLPDSGELGEALAELPHSEVLAYVAGLGVHTAAGTAVAPLRATTVEEVQARVDGIGALRAALPFGIDGIVIKADLAADQQEAGSGTRAPRWAVAYKLPAVEKITRLLAVEWNVGRTGIIAPRAVLEPVEIDGSTVGYATLHNPADITRRDLRLGDQVMVYKAGDIIPRIEAPVVHLRTGDETPIAFPESCPQCGSEIDASEQRWRCTRGRDCRLVASVSYAAGRDQLDIEGLGSTRVVQLVDAGLVADFADLFTLRREQLLALDRMGETSTDNLLAAIETARTRPLSRVFCALGVRGTGRSMSRRIARHFATMDRIVAADAESLQRVDGIGKEKAAAVVAELVELAPLIGKLVAAGVSMTEPGATPPPDPGTEEAAAPATADAGAPGGDAATGSALPLAGMTVVVTGAMSGALEKLSRNQMNELIERAGGKSSSSVSRRTTLLVAGEKAGSKRAKAEDLGVRIAVPEEFAELVGAFLTAGEEA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase 1, Polydeoxyribonucleotide synthase [NAD(+)] 1.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: LIPE_MOUSE
Sequence: MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA
What is the function of this protein?
Exerts both phospholipase and triglyceride lipase activities (By similarity).  More active as a phospholipase than a triglyceride lipase (By similarity).  Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (By similarity).  Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (By similarity).
What are the official names of this protein?
Endothelial lipase, Endothelial cell-derived lipase, EDL, Phospholipase A1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: APT_HAEI8
Sequence: MTTQLDLIKSSIKSIPNYPKEGIIFRDITTLLEVPAAFKATIDLIVEQYRDKGITKVLGTESRGFIFGAPVALALGLPFELVRKPKKLPRETISQSYQLEYGQDTLEMHVDAISEGDNVLIIDDLLATGGTVEATVKLVQRLGGAVKHAAFVINLPELGGEKRLNNLGVDCYTLVNFEGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1028_BACP2
Sequence: MAKESSFDIVSKVELPEVQNAVQAALKEIKNRYDFKGSKSDISLEKEELVLISDDDFKLEQLKDVLVTKLIKRNVPTKNIDYGKTEHALGGTVRQRAKLISGIDQDNAKKINALIKQSGIKVKSQFQDDQVRVTGKNKDDLQEVISLMRKADLPIDVQFINFR
What are the official names of this protein?
UPF0234 protein BPUM_1028.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: MEPA_STAS1
Sequence: MKDEQLYYFEKSSVFKGMMHFSVPMMIGSLLSVIYGILNIYFIGFLGDSHMISAISLTLPIFAVLMGLGNLFGIGGGTYISRLLGAKDYVKTKFVSSFSIYGGLILGVIVILMTIFATEQIAHLLGARGETLGFTSAYLKVMFLSAPFVILFFILEQFARSIGAPIISMIGMLASVVLNIILDTILIFGFDLNVVGAALGTAISNVVASLFFIIYFLRKSDIITMSLSYVRPTKEILVEIFKVGFPAFLMSILMGVTGLVLNLFLAGYGNFAIASYGISFRLVQFPELIIMGLCEGVVPLIAYNFMSDKARMKNIIKVVIMTIVVIFAVCMVIVFTTGHQLIGIFSNDAAIVGMATFMLKVTMTSLLLNGIGFLFTGMLQATGQGRGATIMAILQGVVIIPVLFVMNGLFGLTGIVWSLLIAETICALAAMLIVYLLRDRLTVDKAELLEG
What is the function of this protein?
Multidrug resistance efflux protein.
What are the official names of this protein?
Multidrug export protein MepA.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APE2_YEAST
Sequence: MPIVRWLLLKSAVRGSSLIGKAHPCLRSIAAHPRYLSNVYSPPAGVSRSLRINVMWKQSKLTPPRFVKIMNRRPLFTETSHACAKCQKTSQLLNKTPNREILPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKIGDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKDGKKVTLFNTTPKMSTYLVAFIVAELKYVESKNFRIPVRVYATPGNEKHGQFAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDALADASGKDVRSVMNIWTKKVGFPVISVSEDGNGKITFRQNRYLSTADVKPDEDKTIYPVFLALKTKNGVDSSVVLSERSKTIELEDPTFFKVNSEQSGIYITSYTDERWAKLGQQADLLSVEDRVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFDGTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWVNRDRDVVNKYLKENGYY
What is the function of this protein?
Involved in the cellular supply of leucine from externally offered leucine-containing dipeptide substrates.
What are the official names of this protein?
Aminopeptidase 2, mitochondrial, AP-II, Aminopeptidase II, YscII.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Periplasm. Cytoplasm. Mitochondrion.
Protein: ERF73_ARATH
Sequence: MCGGAVISDYIAPEKIARSSGKSSWRSNGVFDCSIYDFDGNFDELESDEPFVFSSTHKHHASGSASDGKKKQSSRYKGIRRRPWGRWAAEIRDPIKGVRVWLGTFNTAEEAARAYDLEAKRIRGAKAKLNFPNESSGKRKAKAKTVQQVEENHEADLDVAVVSSAPSSSCLDFLWEENNPDTLLIDTQWLEDIIMGDANKKHEPNDSEEANNVDASLLSEELLAFENQTEYFSQMPFTEGNCDSSTSLSSLFDGGNDMGLWS
What is the function of this protein?
Involved in root development through the regulation of root meristem cell division (PubMed:24728113).  Does not act as a transcriptional activator via the cis-acting CRT/DRE element (PubMed:24728113).
What are the official names of this protein?
Ethylene-responsive transcription factor ERF073, AtERF73, Protein HYPOXIA RESPONSIVE ERF 1.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Protein: RFCS_METVS
Sequence: MQKPWVEKYRPENLDEVVGHQEIIKRLKNYVEKKSMPHLLFSGSPGVGKTTAALCLAKDLYGNTWKENFLELNSSDERGIDVIRTKVKDFARTKPIGDAPFKVIFLDESDALTSDAQNALRRTMEKYSDICRFVLSCNYPSKIIPPIQSRCAIFRFSPLKTEDLVKNLKEISEKESINVEKSGMDAIIYVSEGDMRKAINVLQTGAAVSKNINETVIYKVASKARPDEIKKMTELALNGKFVEAREQLYKLMIDWGMSGEDIIIQIFREVPNLEISEKEKVHLVEAIGECDFRIVEGANERIQLSALLAKMGILE
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C small subunit, RFC small subunit, Clamp loader small subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: ZSWM8_MOUSE
Sequence: MELMFAEWEDGERFSFEDSDRFEEDSLCSFISEAESLCQNWRGWRKQSAGPNSPTGGGGGGGSGGTRTRDGLVIPLVELSAKQVAFHIPFEVVEKVYPPVPEQLQLRIAFWSFPENEEDIRLYSCLANGSADEFQRGDQLFRMRAVKDPLQIGFHLSATVVPPQMVPPKGAYNVAVMFDRCRVTSCSCTCGAGAKWCTHVVALCLFRIHNASAVCLRAPVSESLSRLQRDQLQKFAQYLISELPQQILPTAQRLLDELLSSQSTAINTVCGAPDPTAGPSASDQSTWYLDESTLTDNIKKTLHKFCGPSPVVFSDVNSMYLSSTEPPAAAEWACLLRPLRGREPEGVWNLLSIVREMFKRRDSNAAPLLEILTDQCLTYEQITGWWYSVRTSASHSSASGHTGRSNGQSEVAAHACASMCDEMVTLWRLAVLDPALSPQRRRELCAQLRQWQLKVIENVKRGQHKKTLERLFPGFRPAVEACYFNWEEAYPLPGVTYSGTDRKLALCWARALPARPGASRSGGLEESRPRPLPTEPAVRPKEPGAKRKGLGEGISSQRGPRRLSAEGGDKALHKMGPSGGKAKVLGGTGSGGKSSAGSGSKRRLSSEDSSLEPDLAEMSLDDSSLALGAEASTFGGFPESPPPCPSSVGSRGPSTFLPEPPDTYEEDAGVYFSEGPEPPTASADHPGLLPGEVCTRDDLPSTDDSGSGLHKTKEAAPAVGEEDDDYQAYYLNAQDGAGGEEEKAEGGTGEEHDLFAGLKPLEQESRMEVLFACAEALHAHGYSNEASRLTVELAQDLLANPPDLKVEPPPAKGKKNKVSTSRQTWVATNTLTKAAFLLTVLSERPEHHSLAFRVGMFALELQRPPASTKALEVKLAYQESEVAALLKKIPRGPSEMSTIRCRAEELREGTLCDYRPVLPLMLASFIFDVLCAPVVSLTGSRPPSRNWTNEMPGDEELGFEAAVAALGMKTTVSEAEHPLLCEGTRREKGDLALALMITYKDDQAKLKKILDKLLDRESQTHKPQTLSSFYSSSRPATANQRSPSKHGAPSAPGALQPLTSSSAGPAQPGNVAGAGPGPTEGFTEKNVPESSPHSPCEGLPPEAALTPRPEGKVPSRLALGSRGGYNGRGWGSPGRPKKKHTGMASIDSSAPETTSDSSPTLSRRPLRGGWAPTSWGRGQDSDSISSSSSDSLGSSSSSGSRRASASGGARAKTVDVGRCYKGRRPESHAPHVPNQPSEAAAHFYFELAKTVLIKAGGNSSTSIFTHPSSSGGHQGPHRNLHLCAFEIGLYALGLHNFVSPNWLSRTYSSHVSWITGQAMEIGSAALTILVECWDGHLTPPEVASLADRASRARDSNMVRAAAELALSCLPHAHALNPNEIQRALVQCKEQDNLMLEKACMAVEEAAKGGGVYPEVLFEVAHQWFWLYEETAGGSSTAREGATSCSGSGMRAAGEAGRGLPEGRGAPGTEPVTVAAAAVTAAATVVPVISVGSSLYPGPGLGHGHSPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATAVSFPVPSMAPITVHPYHTEPGLPLPTSVALSSVHPASTFPAIQGASLPALTTQPSPLVSGGFPPPEEETHSQPVNPHSLHHLHAAYRVGMLALEMLGRRAHNDHPNNFSRSPPYTDDVKWLLGLAAKLGVNYVHQFCVGAAKGVLSPFVLQEIVMETLQRLNPIHAHNHLRAPAFHQLVQRCQQAYMQYIHHRLIHLTPADYDDFVNAIRSARSAFCLTPMGMMQFNDILQNLKRSKQTKELWQRVSLEITTFSP
What is the function of this protein?
Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184237).  The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (By similarity).  Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (By similarity).  May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (By similarity).
What are the official names of this protein?
Zinc finger SWIM domain-containing protein 8.
What is the protein family that this protein belongs to?
Belongs to the ZSWIM8 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CH10_RUBXD
Sequence: MKFKPLGERALVKLVEREEKTASGIVLPDTAKEKPQTAEVIAVGDSEDIKVKEGDVVVFAKYSGTEISLNGDDYMILDADDILGVVEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_DESRM
Sequence: MGQKVNPKGLRVGIIKDWEGKWFADKRNYSNLLIEDVKIREYIKRKLYQAGISRIQIERAANRVKVSIHTAKPGIVIGRGGAEVEALRKELEKMTAKQVHVNIVEVKTPEVDAQLVAENIASQLEKRIAFRRAMKQTVQRSLRMGAKGIKIACSGRLAGAEIARTEWYSEGKVPLHTLRADIDYGFAEANTTYGKIGVKVWIYKGEVLPEAKKPAAGQGGE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: AQDB2_RHOER
Sequence: MTQRNAIVVGGGIGGLTAASALARQGWRVQLHERQPEIRAVGAGIYIWDNGLFALDAVHAYSEAIEGAHEPPSIDMRGQSGKTLMRIKINGESQPRCLTLLRDQLIKALVNAAKDAGVELVTNSSVVAVRPEGEVHFEHGDHSTTDLVVVADGVHSRLRDSVDLSYSRIRMSQGAARIMIPQSSHELPAEDRGRILESFHGSRRLLYTPCTPELVYLAFTCDSDDPAISGAYINTSEWSRSFPTLSDALRATEGVPATRWDTFEYVRLASWSRGKVAFLGDAAHAQPPYLGQGGGTAMTNAIALANAVSSDMELSEALATWERITRPGIESTQRTSYQQRLLNYVPDRVRNPLVRIAGLTSNVAKSQLKATEIRPTLGSTGGSR
What is the function of this protein?
Involved in the degradation of the Pseudomonas aeruginosa quorum sensing signal molecule HHQ (2-heptyl-4-quinolone) to anthranilic acid.  Probably catalyzes the hydroxylation of HHQ to PQS (2-heptyl-3-hydroxy-4-quinolone).
What are the official names of this protein?
Probable 2-heptyl-3-hydroxy-4(1H)-quinolone synthase AqdB2, 2-heptyl-4-quinolone monooxygenase, HHQ monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxybenzoate 6-hydroxylase family.
Protein: YL157_MIMIV
Sequence: MTTIIIDSTVDLYYDHDEQLKKIRLKEPFYFKIPSGLEVQIGQNKFIIVEELHIEPDVNTLLSNVCEKGIIQEIPSDTSIIPECYGFSTRLESPLKVYLPLDTKVKLPVGTKLKQKEIYAFFNLETEVDGIIFSSVIPSILVDRLNVKIDIEGNTVNNEYLMNIPLYEKHEDLLIDFEEKTSPNNKSRNKSRNESQDKSRDKSRKKVCNTHKNKKTLDNVKPDKNIKISVSSNKFTTNKPKSNKNSSDSDGSTKTTKSTRSTKSTKSSKSQKSTRNSDVKLIELSDSNQYSEDIPLVRKKKNKNPKESINHKKNDSKQNIFVEKFKNKNNKNDSTNCRKSNRTTTRDVTNSDSEQKVENKNRSWLSESISSESDKSDSEQSDLTEDETEENVSEEDETEEDETACYIDNKDYRKLLSKLSQYLEPKYDIVKIANYIWVNWDLKKINKMGVKDVLSLFLEGNNNRLNESDFYLKNYKLFDSDDTDDTDDTNNSCSSEVDDSD
What are the official names of this protein?
Uncharacterized protein L157.
Protein: YJMC_BACSU
Sequence: MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNVHSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAIDMAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTNPIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVVSLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFFTDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFLKSR
What are the official names of this protein?
Uncharacterized oxidoreductase YjmC.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F124B_MOUSE
Sequence: MDEIQEPLALTVHLLADTGNGLLLQQALDQLLECICPEVRLFLVSERARPVNYHEKYHPRRARFPGMSVLLFLQESLGQERLFRVLDFLRRSPWQGFPTQHAQGRSCSYLPANQEFYSLHNQMPVWGMRPVNCGTDILRVTLYCSFDNYEDAIRLYEMLLQRDATVQKSDFCFFVLYATEGFSLQLSLKQLPLGMSVDPKESSVLQFRVQEIGQLVPLLPNPCVPISSARWQTQDYDGNKILLQVHPKPGVGIKNGEHPFLNGCLRGDTHPQDSSLNSVSTQRTLEPRSRRRSRSRRFKVHSLELPQPSGSWENSTDPLWRRLGWSTLADSSASGMQQRRLSIPIEPKMGRNVLREDGFEKLEAETNVDTGFTIINSEPRRSFPSRFPRDFQSSQPPRCLSGSSLEVTVSPNQGVFKDRLHPLSLPSQRDFGAKKVISKCSHHLQAQGEEKEEFFI
What are the official names of this protein?
Protein FAM124B.
What is the protein family that this protein belongs to?
Belongs to the FAM124 family.
What are the subcellular locations of this protein?
Nucleus.