PharMolix/UniProtQA huggingface dataset:
Protein: HEMH_AZOSB
Sequence: MARFWTEAPHRHGSTARTGILLVNLGTPVAPTAAALRPYLQQFLSDPRVVEIPRAVWLPLLNGVILNTRPRKSAAKYASIWTDEGSPLAVHTRRQAELIAARFASRDDVRVDWAMRYGAPAVADKLGALRAAGCTRILVVPMYPQYAASTTASVMDEVARCLQHWRNLPELRFVRSFHDDPGYIGALAASVREHWTRHGQPDRLLMSFHGLPRYTLERGDPYHCECHRTARLLAESLGLAPERVIVSFQSRFGRTRWLEPYTQPTLEALARDGVGRVDVMCPGFVADCLETLEEIAMECRAAFLGAGGREFHYIPCLNERPDWIDALERRVRSEAGNWLTATPPTDAEREAARGRALALGAAE
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRSA_STRA1
Sequence: MKTRSKLAAGFLTLMSVATLAACSGKTSNGTNVVTMKGDTITVSDFYDQVKTSKAAQQSMLTLILSRVFDTQYGDKVSDKKVSEAYNKTAKGYGNSFSSALSQAGLTPEGYKQQIRTTMLVEYAVKEAAKKELTEANYKEAYKNYTPETSVQVIKLDAEDKAKSVLKDVKADGADFAKIAKEKTTATDKKVEYKFDSAGTSLPKEVMSAAFKLDKNGVSDVVSTVDSTTYKTSYYIIKVTDKTEKKSDWKSYKNRLKEVILKDKTSDRAFQNKVISKALEKANVKIKDKAFAGILSQYATTSGSSSLKK
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: MRAZ_CHLL3
Sequence: MAGFIGKEKHAVDEKGRLMIPARFRRKFPETSGSLASKKEPASLYVMKSPDSSLELYLPDVWEEMARTISALSDFHPDERLLKTLMYESLEMVELDRQGRIPLSREFLDHAGITRDVVIIGADTKMIVWEPGRLSEVLEGSSGRFAALAGRYF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CHI2_GOSHI
Sequence: EQCGRQAGGALCPGGLCCSQFGWCGSTADYCTVPGCQSQCSGSGPAPGPGGLTNLISRETFNQMLLHRNDGACPARGFYTYDAFIAAARSFPAFATTGDQATRKREIAAFLAQTSHETTGGAGWAAPDGPYAWGYCYNRELNPPSSYCASDPNYPCAPGKQYFGRGPMQLSWNYNYGQCGRAIGVDLLNNPDLLSSDPTISFKSAFWFWMTPQSPKPSCHNVIIGAWSPSSSDRAAGRATGYGVITNIINGGLECGKGWNAQVEDRIGFYKRYCDILGVSYGNNLDCYNQSPFGNGVSVDSM
What is the function of this protein?
Defense against chitin-containing fungal pathogens.
What are the official names of this protein?
Endochitinase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: DCDB_CORDI
Sequence: MLYSDKDIRVAIDAGELGIEPFDADLIQPSSIDVRMDRLFRVFNNSKYTHIDPKQQQDELTSLVEVPEGEPFVLHPGEFVLGSTLEKFTLPAHIAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGYITLELSNVANLPITLWPGMKVGQLALFKMTSPAQAPYGSNVLGSKYQGQRGPTPSKAYLNFR
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: TPS2_MAIZE
Sequence: MYSLPGATMSAAPASIISSSSFVEPLLLAAASPAAAAAAANSHHQVRQRGHLVRTLAASSSSNTLLRSDFDLQEGLTTDVKRMLRQRQKKSGGGREMLVTIDNLKRLCIDHYFEEEIEGAMATGACTRLLHSDDLFDATLAFRLLREAGHDVSAKDDVLRRFIDGASGDFKLSLSNDVRGLLSLHDMSHLDVGGEAALLHRAKEFSSRHLASAVRYLDDPSLAEYVRQSLDHPYHLSLTQYKARHHLRYLQSLPSRDAAVERLAVAEFQLNKSLHQGEMREIKRWWMDLGLAEEIPVVRDQVMKWYMWSMAALQGSSFSRYRVEITKIISLVYVVDDIFDLVGTLEELSAFTEAVKMWDTVAADSLPSCMRSCYKALHTVTNEIAEIAQKEHGSNHVNRLRKAWAVLFDGFMVEARWLATDQVPTAEDYLRNGVITSGVPLTFMHIFSMLGYDDPSTEEEEEAIIDHMPSIISCPAKILRLWDDMGSAEDEAQEGFDGSYRDFYLMENPSRSPGEAEAHMRGLIAREWEVLNRECFCRRTFPSNLVQVCLNTARMVSVMYSYNKEQRLPVLEDYAAMMLVL
What is the function of this protein?
Involved in sesquiterpene (C15), diterpene (C20) and monoterpene (C10) biosynthesis.  Has sesquiterpene synthase activity, converting farnesyl diphosphate to nerolidol, the precursor of the volatile C11-homoterpene (E)-3,8-dimethyl-1,4,7-nonatriene (DMNT).  Has diterpene synthase activity, converting geranylgeranyl diphosphate to (E,E)-geranyllinalool, the precursor of the volatile C16-homoterpene (E,E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene (TMTT).  Has monoterpene synthase activity, converting geranyl diphosphate into linalool.  Forms only the S-isomers of the three tertiary terpene alcohols.
What are the official names of this protein?
Terpene synthase 2, chloroplastic, (3S,6E)-nerolidol synthase, (E,E)-geranyllinalool synthase, S-(+)-linalool synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SC7_SCHCO
Sequence: MKLTVILLTAVLAASASPAPVDVDARAPVALDSRSPIDIDSRSADALANRAAPPQSEIDQWLKAHNNERAQHGAVALVWNQTLSDKAADWASQCIWEHSNSGQNLAAWFSPQANKPMNISQGVGGWNAEEPDYNTTTYSGAGHWTQVVWKSTTSVGCAAYSCPPGTLGRKPTDPWKTLWYYVCNYYRPGNVSPRDKYYPINVQP
What are the official names of this protein?
Fruiting body protein SC7.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: NNRD_DROME
Sequence: MAAVSDIPVHLPKLLALFKTVVPKLVNNKHKGQYGRIGVIGGSLEYTGAPYFAAISSIRVGADLAHVFCHSNASAIIKSYSPDLIVHPVLDCVDAVERIAPWLERLHVVVIGPGLGREPGILKTASNVLKLCMDTKKPVVIDADGLFLLNDNLNLICGQPNVILTPNVMEFQRLFGEDDQAARQKMSLLGAGVTVLEKGANDKIYLPHCNEVHSMPSGGSGRRCGGQGDLLSGSLATFFSWSLQSGEPNPALVAACASSYFVKKLNAAAFQKFGRSLLASDMVNQIPSVFQTEFENSDPQ
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ATP-dependent (S)-NAD(P)H-hydrate dehydratase, ATP-dependent NAD(P)HX dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
Protein: SYK_ACIAD
Sequence: MAQPNVQSTSEPILSENDLIAQRHAKLKQIQDKAKETGKSVWPNTFKREHYAADLQEQFKDIDKAQIEGSDKTYVKVAGRVMLNRGSFMVIQDMTGRIQLYVDRKGLPADTLETIKSLDLGDIIAAEGYIGRSGKGDLYVHLEGFELLTKSLRPLPDKFHGLTDTEAKYRKRYLDLIVNEETRKTFEIRAQVVAGIRAFLTNQRFMEVETPMMHVIPGGASAQPFVTHHNALDMELYLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSTRHNPEFTMIEFYQAYADYKDLMQLTENMLEKLALDILGTTDVPYGDEVYSFKGPFKKISMFDAILEHNPDFTPENVNDREFLAKFTQDVLKEQVKPGFGLGKLQTIVFEETVETKLRQPTFITEYPAETSPLARRNDDNPHITDRFEFFIGGRELANGFSELNDPIDQAERFQAQVAEKDAGDDEAMHYDADFIEALEYGLPPTAGQGIGIDRLVMIFANAPSIRDVLLFPHMRRKDV
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR18_LEPVR
Sequence: MNKSKRLFTKSKRSFRRRLPPIQSGDRIDYRNMSLISRFISEQGKILSRRVNRVTLKQQRLITIAINQARILSLLPFLNNQKQFERSESTPRTTSLRTRKK
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUP42_YEAST
Sequence: MSAFGNPFTSGAKPNLSNTSGINPFTNNAASTNNMGGSAFGRPSFGTANTMTGGTTTSAFGMPQFGTNTGNTGNTSISAFGNTSNAAKPSAFGAPAFGSSAPINVNPPSTTSAFGAPSFGSTGFGAMAATSNPFGKSPGSMGSAFGQPAFGANKTAIPSSSVSNSNNSAFGAASNTPLTTTSPFGSLQQNASQNASSTSSAFGKPTFGAATNTQSPFGTIQNTSTSSGTGVSPFGTFGTNSNNKSPFSNLQSGAGAGSSPFGTTTSKANNNNNVGSSAFGTTNNQSPFSGGSGGTFGSASNLNKNTNGNFQSSFGNKGFSFGITPQNDANKVSQSNPSFGQTMPNTDPNISLKSNGNATSFGFGQQQMNATNVNANTATGKIRFVQGLSSEKDGILELADLAEETLKIFRANKFELGLVPDIPPPPALVA
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).  NUP42 is specifically important for nuclear protein and mRNA export.
What are the official names of this protein?
Nucleoporin NUP42, Nuclear pore protein NUP42.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL18_ACTPJ
Sequence: MDKKVARIRRATRARHLMREQGATRLVVHRTPRHIYAQVIAPNGSEVLAAASTVEKVIKEQVKYTGNKDAAAVVGKLVAERALAKGIQAVAFDRSGFKYHGRVQVLADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RL30_ECO57
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAIRGMINAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ENPP7_RAT
Sequence: MGHSAVLLSVALVILPACVTGGPVQRQQQHKLLLVSFDGFRWNYDQDVETPNLDSMAQEGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTNKVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRANVDTVMKWFTEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLTDSLNLIITSDHGMTTVNKKASDLVEFHKFPNFTFRDIEFELLDYGPNGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFNSGEHGFDNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPNDGHPGVLQPMLRSGSPLSRQHHLVVVLMGILTGLAKVV
What is the function of this protein?
Choline-specific phosphodiesterase that hydrolyzes sphingomyelin (SM) releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:16255717, PubMed:15708357).  Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation.  Does not have nucleotide pyrophosphatase activity (PubMed:16255717).  May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity).
What are the official names of this protein?
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7, E-NPP 7, NPP-7, Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-SMase.
What is the protein family that this protein belongs to?
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=The catalytic domain is released into the extracellular medium when cells are treated with trypsin (PubMed:15205117). Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex (By similarity).
Protein: SR1P1_ARATH
Sequence: MSAKKKDLLSSAMKRTSEWISSQEVSSDVTVHVGEASFSLHKFPLMSKCGFIKKLVSESSKDSDSTVIKIPDIPGGSEAFELAAKFCYGINFDMSTENIAMLRCAAEYLEMTEEHSVENLVVRAEAYLNEVALKSLSSSITVLHKSEKLLPIAERVKLVSRCIDAIAYMTCQESHFCSPSSSNSGNNEVVVQQQSKQPVVDWWAEDLTVLRIDSFQRVLIAMMARGFKQYGLGPVLMLYAQKSLRGLEIFGKGMKKIEPKQEHEKRVILETIVSLLPREKNAMSVSFLSMLLRAAIFLETTVACRLDLENRMGLQLGQAVLDDLLIPSYSFTGDHSMFDTDTVQRILMNYLEFEVEGVRLSNNGVDLAGDMERVGKLLENYMAEIASDRNVSLQKFIGLAELIPEQSRVTEDGMYRAVDIYLKAHPNMSDVERKKVCSLMDCQKLSREACAHAAQNDRLPVQTIVQVLYYEQQRLRGEVTNDSDSPAPPPPQPAAVLPPKLSSYTDELSKLKRENQDLKLELLKMKMKLKEFEKESEKKTSSSTISTNPSSPISTASTGKPPLPRKSFINSVSKKLGKLNPFSITPYNGRGRTKPPKDRRHSIS
What is the function of this protein?
Acts as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (Probable).  Involved in disease resistance.  Acts as a substrate adapter that recruits CAMTA3/SR1 for ubiquitination and degradation during pathogen infection.  Acts as positive regulator of plant defense by removing the defense suppressor CAMTA3/SR1 (PubMed:24528504).
What are the official names of this protein?
BTB/POZ domain-containing protein SR1IP1, Protein ATSR1-INTERACTION PROTEIN 1.
What is the protein family that this protein belongs to?
Belongs to the NPH3 family.
Protein: VKTJ1_CYRHA
Sequence: MGIARILSAVLFLSVLFVVTFPTLLSADHHDGRIDTCRLPSDRGRCKASFERWYFNGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Serine protease inhibitor that inhibits trypsin and blocks voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hhn1j, U15-TRTX-Hhn1j, Kunitz-type serine protease inhibitor hainantoxin-XI-10, HNTX-XI-10.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 01 (intermediate) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DED1_ASPNC
Sequence: MADSLKMGNLSLNESQHAPAPAPSTGRAAYIPPHLRGRQMGGNMDGAAAAAPPPGPAAGPGNSWGGPRGGPRGGQWANANAPDFSPRGPNGNTSWSPHEARRPFNPNAYGHPGHGGSYGSGGGSARGSGDGQWRDGKHIPGPANPRLERELFGLPNDPTKQNTGINFANYDDIPVEASGHDVPEPVNAFTNPPLDDHLIENIKLAHYQTPTPVQKYSIPIVMNGRDLMACAQTGSGKTGGFLFPILSQAYQNGPSAAPAQAGGQFGYGRQRKAYPTSLILAPTRELVSQIFDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLVNIKYLILDEADRMLDMGFEPQIRRIVEGEDMPHVNDRQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKVEYVEDHDKRSVLLDILHTHGTSGLTLIFVETKRMADSLSDFLLNQRFPATAIHGDRTQRERERALEMFRSGRCPILVATAVAARGLDIPNVTHVINYDLPTDIDDYVHRIGRTGRAGNTGIATAFFNRGNRGVVRDLIDLLKEAHQEVPSFLESIAREGSGYGGRGGRGGRGRGANATRDMRRMGGGMGGPPSFGGSSYGAPGGSYGGGGGGSSSYGAPPSYGGGGGYGGGGSYGGGYGNPSGPTGPSSWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase ded1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: I20L2_RAT
Sequence: MSTILLNLDFGEPSKKAFGGNAKHQRFVKKRRFLEQKGFLSKKNQPPSKVSKLNSEPPKKGETSRVDSISKILSCLKKKKEAAASKRDSEQSKDKKASLSWLTPAPSKKTDSVVAKIDLLGEFQSALPKPKRRTQKKGSKKPLKKKIATENSTQTQSKDKGSNKKPLKKNAVQNSTQAQPEDKCPKVPQSLPRKMVAIDCEMVGTGPKGRVSSLARCSIVNYNGDVLYDEYIRPPCYIVDYRTRWSGIRKCHMVNATPFKTARSQILKILSGKVVVGHAIHNDYKALQYFHPKSLTRDTSQIPLLNRKADCPENVTLSLKHLTKKLLSRDIQTGLSGHSSVEDAQATLELYKLVEVEWEQHLAQNPPEN
What is the function of this protein?
3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA.  Displays a strong specificity for a 3'-end containing a free hydroxyl group (By similarity).
What are the official names of this protein?
Interferon-stimulated 20 kDa exonuclease-like 2.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: Y836_TREPA
Sequence: MTRSQWHALAAFRTDLKAFCVQSLRAFGYPYMDPHAAQSAVACCTPQAFLHRAQAALVRAQGIPTYPVHTPIVYPHALEELTQSDPVPALILVSDNPGKEEQLHTQQRYLVGQSGRVAQGFFSRHAQLGVDFRTDVMLLNKTPLHTAKTVQLRALVRLLAQDPAGTARARQVQSFLHRSQCWMARRTCQLQRSLGCDLWIVGYSELKSGHLFEPYARLLQTVCDRRTPLFVFQHFSMNCFARDFAKARARSPQQQVCDTLKDLGLHHRQQILGF
What are the official names of this protein?
Uncharacterized protein TP_0836.
Protein: NUOD_PELPD
Sequence: MEYKSPVRSNLEQTADPNHVLVNMGPSHPATHGTIQIIAALDGERVAKADIHCGYLHRGFEKESEHHTYHKIIPFTDRLNYCSALNNNFAYVEGVEKLLGIELTPRCIYLRTLLAEYNRVADHVTCVAATVMEMGAMTAFLYLMTIRDYIFEHLNQLTGARLTYSFARVGGLKNDLPDGWLERLEEILQFTEKYCGRIHGLLDRNRIFIDRTRDVGAMSPEHALNWGYTGPILRSTGAKIDIRKDNPYLAYADLDFEVPVGIKGDNYDRYYVRMREIDESISMVRQCMKKLPDGPVNIDDRRIMYPTKDKVYTKIEYLISHFKLVIDGIQVPAGEIYVSHEAPNGELGFYLISDGSGRPYKLHVRSPSFAHMGGMHTLLEGYQVADVIATFGSMNMIGGECDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CP4F_SHEEP
Sequence: MLELSVSRLGFGLVAASPWLLLLVVGASWLLARVLAWTYTFYNNCRLLQCFPQPPKQNWFFAHLYLVPPTEQGLRKSTQLAANYSHGYLIWFGPITPMIVFCHPDMLRSIANASAAVAPKNMDFYKFLKPWLGDGLLLSAGDKWSRHRHLLTPTFHFNILKPYMKIFTKSTDIMHTKWERLITQGHTRLDMFEHLSLLTLDSLQKCVFSFDSNCQELSSCRKPSKYITAILELSELVAKRNRQIFLHADFLYFLTLDGWRFLRACRLVHDFTDAVIQERCRTLPENVDDFLKAKAKTKTLDFIDVLLLTKDEDGKRLSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRESKEIEWDNLAQLPFLTMCIKESLRLHPPVTIISRCCTQDIVLPNGWVIPKGVICIIDIFGTHHNQSVWPDPEVYDPFRFDQENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRFLPDKEEPRRKRELILRAEGGLWLQVEPLSASPQ
What is the function of this protein?
A cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of prostaglandin E2.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Prostaglandin E2 omega-hydroxylase CYP4F21, Cytochrome P450 4F21.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein.
Protein: RL31_PROMT
Sequence: MPKSDIHPTWYPEAKVICNGEVVMTTGATQPEIQVDVWSGNHPFFTGTQKILDTEGRVDRFMRKYGMASSDSSEQKDKSSEEKKES
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: NRDR_ANADE
Sequence: MRCPYCGHLEDRVVDSRETQDGQATRRRRACLSCERRFTTYERIEDVLPQVVKKDGRREAFDRAKIVEGVATACQKRPVSAEQVEALVSAVERQVQELGEREIRTAVIGEAVMQRLRTLDEVAYVRFASVYRAFRDVGEFMTELAGLARKDGGEER
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: GCH1_THEPX
Sequence: MIDKEKIKKAVRDILEAIGEDPDREGLLETPDRVARMYEEIFAGLHTDVKDVIKIFQEDEHQEIILVKDIPLYSMCEHHLLPFIGVAHVAYLPRKGRILGLSKLARIVDILAKRPQLQERLTSEIADTIMEAVNPLGVAVVIEAEHLCMTMRGIKKPGAKTVTSALRGIFRTDEKSRAEVMSLINSKK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: XGPT_SALTY
Sequence: MSEKYVVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVIDIPQNTWIEQPWDMGVVFVPPISGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KMO_GRAFK
Sequence: MQKEKDVAIVGSGLVGSLLAIFLRKQGHKVTVFDRRPDVRNVQFSGRSINLAMSNRGWKALREAGIEDEIRELALPLDKRAMHVEGQSVYFQKYGEEGEAIYSISRGILNRKMIDLAESAGATFRFEEKIWDVDMKEARLYTGESEKSVWKEYQFDLIFGADGAFSRVRHKMQRQSRFNYSQHFIDVGYKELTILANEDGSHKMDNSSFHIWPRGNFMLIAMPNLDGTFTCTLFMPFDGETSFESIKTEDEADIFFEKYFPDIKDEISNLKKDFFKNPTSAMVTIKCFPWSYFDKITLVGDSAHAIVPFYGQGMNAGFEDISVLNEKMNLYGDDWEKVFEDYQTERKPNADAIAELSYRNFVEMSKKTADPKFLLRKKIEQKFAENHPDLWTPLYSRVTFSDKAYSDALKIGDYQREIMDEVMKIPGIEEKWESSEVEEKIISLIKK
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Protein: SYA_HERAR
Sequence: MKSSEIREKFLKFFESKGHTIVASSPLVPGNDPTLMFTNSGMVQFKDVFLGEDKRPYVRATSVQACLRAGGKHNDLENVGYTARHHTFFEMLGNWSFGDYFKRDALMWSWELLTKVYGLPGDKLLATVYIEDQEAYDIWTKEIGLPPERVIRIGDNKGGRYKSDNFWMMADTGPCGPCSEIFYDHGPHIAGGPPGSPDEDGDRYIEIWNNVFMQFDMAEDGTVKPLPAPCVDTGMGLERLAAILQGVHSNYEIDTFAALIKAAGRETNTKDLTNNSLKVIADHIRATAFLVADGVIPSNEGRGYVQRRIIRRAIRHGYKLGQKKPFFHKLVKDLVEQMGEAYPKLQADAQRITEVLKAEEERFFETLANGMEILDAALAGGVKVLPGEVAFKLHDTFGFPLDLSADVCREAGVSVDEAGFAAAMEKQKAAGRAAGKFKMERAVEYTGAGNVFTGYENLQEDATVVGLYFEGTAVQQLKEGQAGIVVLDTTPFYAESGGQVGDQGFVSAEGVQFGVEDTQKIKADVYGHHGVQTQGTLKVGDKVQAAVDGARRAATMRNHSVTHIMHKALREVLGEHVQQKGSLVDAEKTRFDFAHNAPVTHEQILEIEKRVNAEILANSDTQARVMDIESAQKTGAMMLFGEKYGETVRVLDIGSSRELCGGTHVSRTGDIGLFKVVGESGVAAGVRRIEAITGANALSYFQDLEATVHSAAATLKSPPAELQPRLAQVLDQVKTLEREINALKGKLASSQGDELLSQAVEIKGIKVLAAKLENADAGTLRTTMDTLKDKLKTAAIVLAAVNDGKVSLIAGVTADATGKVKAGELVNFVAQQVGGKGGGRADMAQAGGTDASGLPAALQGVAAWVAERA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_BACAC
Sequence: MGTILDKIVNQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSSSIHTFFEDCKVNI
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: APLD1_HUMAN
Sequence: MFRAPCHRLRARGTRKARAGAWRGCTFPCLGKGMERPAAREPHGPDALRRFQGLLLDRRGRLHGQVLRLREVARRLERLRRRSLVANVAGSSLSATGALAAIVGLSLSPVTLGTSLLVSAVGLGVATAGGAVTITSDLSLIFCNSRELRRVQEIAATCQDQMREILSCLEFFCRWQGCGDRQLLQCGRNASIALYNSVYFIVFFGSRGFLIPRRAEGDTKVSQAVLKAKIQKLAESLESCTGALDELSEQLESRVQLCTKSSRGHDLKISADQRAGLFF
What is the function of this protein?
May be involved in angiogenesis.  May play a role in activity-dependent changes of brain vasculature.  May affect blood-brain permeability.
What are the official names of this protein?
Apolipoprotein L domain-containing protein 1, Vascular early response gene protein.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.