PharMolix/UniProtQA huggingface dataset:
Protein: MURB_ACIBY
Sequence: MFKNRFFNTMQIQNQVQLKPFNTLSLDVTASHYTKVKSIEDIEEALAFAKEHELNVLVLSGGSNMLLPQQINALVIHLDIQGIDVLSEDQDFIRVKVGAGQVWHDFVLYTTKQNWFGLQNLALIPGLVGASPVQNIGAYGVEVGEFIESVQVYDRLLKQTGSISAADCHFSYRHSIFKDDPARYIITHVTFKLLKQANLKLNYGDLKQAVGDNLTAENLQNQVIHIRQSKLPDPKEYPNVGSFFKNPIVNTQEFERLIAQFSTIPHYPQANGNVKIAAGWLIDQAGWKGKQLGVVGMFHKQALVLVNYANASLADVKKTYQAVQHDVEQRFQIMLEPEPVLYNNLGLIENHTE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_METS5
Sequence: MQRLTIRDFLKKKGKEKITMLTVYDYSMAKILSETEVDGFLVGDSLGMNVLGFPSTLQVTMDHMIHHTRAVVRASPRQLIVVDMPFMSYEPSNEVAVKNAGILASEGADAVKLEGGVEVYERVANIVKFGVPVMGHIGLTPQRYLTLGGYRTVKDEAKLISDALALEEAGAFSIVIENVYAEIAKKITEKVSIPTICIGAGPHCDGQVLVIHDLLGMGDIQPYFSRKYLDLKAEIREAVKRYINDVKTGTFPGRENYKSRES
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR4_HAES1
Sequence: MLHIFRGTPALSNFRLNQLFSGFQQDNLPIVSCYAEFLHFAHLSEALTEIEREKLEELLRYGPTQKSQEPYGECFVVIPRIGTISSWASKATDIAHNCDLNKVLRLERGIAYYFKFNRTLTAEEEQQLVFRIYDPMMESIVRSPQEAAVLFEQHDPKPFTTVDILTGGHVALEKANVTLGLALAKDEIDYLVENFTALGRNPTDVELYMFAQANSEHCRHKIFNADWIIDGKKQDKSLFKMIKNTFEKTPDYVLSAYKDNAAVMEGSKVGRFFPDQDGQYRYHQEDTHILMKVETHNHPTAISPFPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLCIPNFPQPWENALSKPSRIASALDIMIEGPLGGAAFNNEFGRPALLGYFRTYEEKVNSFNGEEVRGYHKPIMLAGGIGNIRHEHVQKGEIPVGAKLIVLGGAAMNIGLGGGAASSMASGKSKEDLDFASVQRDNPEMERRCQEVIDRCWQLGSENPILFIHDVGAGGLSNAMPELVHDGGRGGRFELRKILCDEKGMSPLEIWCNESQERYVLAVSPEKLPLFEAICQRERASFAVIGEATEQQQLTLQDSHFNNNPIDLPMNILLGKTPKMIRDVKSAKVNNPQLDQSMIQIKEALFRVLRLPAVAEKTFLITIGDRSVTGMVARDQMVGPWQVPVADCAVTTASLDSYHGEAMSIGERTPVALLDFAASARLAVAESITNIAATDIGDIRRIKLSANWMAAAGHGGEDAGLYEAVKAIGEELCPQLGLTIPVGKDSMSMKTTWQEEGYQKSVTAPLSVIISAFARVEDVRKTVTPQLRMDKGDSRLLLIDLGEGKNRLGATALAQVYKQLGDVPADVVNVSLLKGFFNAMQALVKQEKLLAYHDRSDGGLIVTLAEMAFAGHCGISIDISALGDNDLGVLFNEELGAVIQVKESDLKAVRAVLTEHGLIHLTKELGIVTADDHIEITRSTRVLLSEKRSVLRGIWAELTHQMQRLRDNPDCADQEFEMKKDPNDKGLSAYLTYDLNEKITAPYIQKGTKPRIAILREQGVNSHYEMAAAFDRAGFNAIDVHMSDLQKGRHHLQDFNALVACGGFSYGDVLGAGGGWAKSILFNTALRDQFSAFFHRQDTLALGVCNGCQMLSNLAEIIPGTENWGRFVRNKSERFEARVAMVRINNTHSVWFDGMAGSHMPIAVSHGEGRIEFKHDQQLQALKAQNLIAAQYIDSQLNPTEIYPANPNGSAEGITALSNSNGRVAIMMPHPERVFRAVNNSWYPENWQEDGAWMRLFQNARVALG
What is the function of this protein?
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANP_NOTNE
Sequence: VTAAPAATAATAATPATAALNFAATAATPATPATPALIFAATAATAATPATAALNFAATAATPATAATPALIFAAAAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATPAFHFAATAATPATAATPALIFAATAATAATPATPAFHFAATAATPATAATPALIFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATAALNFAATAATAATPATAACNFAATAATPATAATPALIFAATAATAATPATAACNFAATAATPATAATPALIFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATAALNFAATAATAATPATPAFNFAATAATPATAATPALIFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATAALHFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATAAFNFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATPAFHFAATAATPATAATPALIFAATAATAATPATAALNFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATAALNFAATAATPATAATPALIFAATAATAATPATAAFNFAATAATAATPATAATPALIFAATAATAATPATPATPALIFAATAATAATPATPALNFAATAATAATTAARG
What is the function of this protein?
Antifreeze proteins lower the blood freezing point.
What are the official names of this protein?
Ice-structuring glycoprotein, ISGP, Antifreeze glycopeptide polyprotein, AFGP polyprotein.
What are the subcellular locations of this protein?
Secreted.
Protein: PSAM_EUGGA
Sequence: MAIDNTQIFIALLTALIPAFFALKLGKELSK
What are the official names of this protein?
Photosystem I reaction center subunit XII, PSI-M.
What is the protein family that this protein belongs to?
Belongs to the PsaM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: KN14L_ORYSJ
Sequence: MADTRGRWAWDVPGFEPPQPVVGAAAGMPLAPPTAMPRAPPTAMVARAAGADGAVVPVADRLDQLADSVQLAREDCLELRQEASDLLEYSNAKLGRVTRYLGFLADRTRKLDQAALETEARITPLIHEKKRLFNDLLTLKGNVKVFCRSRPLFEDEGSSVVEFPDDFTIRVNTGDESLTNPKKDYEFDRVYGPHIGQGELFHDVQPLVQSALDGYNVAIFAYGQSRSGKTHTLEGSSHDRGLYLRSFEELFDLSNSDTTSTSHFNFYITACELYNDQVRDLLSDSISPVPKVRMGVQESFVELVQEKVENPLEFSNSLKAALENRSANSLKVMVSHLIVTIHIHYRNYVTGEHLYSKLSLVDLPASECLLEEDANRDNVTDFLHVSKSLSALGDALASLSAKKEPVLSGNSRITQILADSLGSSSKTLLIVHVSPSASNLSRTLSTLSFSARAKNAELSLGNRDTIKKWKDVANDSRKELHDKEKEVLDLRQEVLGLKLSLKEANDQCTLLFNEVQKAWRVSSTLQADLKSENLMLAEKHRIEKEQNNQLRDQISRLLEVEQEQKIKMHERDLTIQSLQAKLKSIESQLNEALNSSDARSTIGSESASVISTPKMMESTADSSSVTKRLEEELAKRDALIEKLHEENEKLFDRLTEKSGLGSSPQAPSPSNKQTNAQGRDIGRSDSTKSQSSDVFPLPVSQDKAGNSGAIVKSSNELTKTTPAGEYLTSALMDFDPNQFEGVAAIADGANKLLMLPYFHCHRDYNETPPISDWCMVLAAVIKAGAAREHEILAEIRDAVFSFIRKMEPRKVMDTMLVSRVKILYIRSLLARSPELQSIKVSPVERFLEKSHTSRSRSSSRGSSPGRSPVHHHHDHGSRTSLIDEHVHGFKVNIKPERKSKFSSIVLKLRGIEEETWRQHVTGGKLREITEEAKAFAIGNKALAALFVHTPAGELQRQIRAWLAENFEFLSVTGGDVAGASGQLELLSTAIMDGWMAGLGTARPPSTDALGQLLSEYTKRVYTSQLHHLKDIAGTLATEVADDPAHVSKLRSALESVDHKRRKIMQQMRTDTVLLTKEEGGSPIRNPPTAAEDARLASLISLDNIIKQVKEVMRQSSARPLRKSKKKALLESLDDLLAQMPSLLDVDHPCAQKQIMEARKVVESLQEDPDEPATDLNSNTLGESEVSQWNVLQFNTGTSAPFIIKCGANSSCELVIKADQKIQEPKGDEIIRVVPKPSVLAEMSFEEIKGVFEELPEAISLLALARTADGTRARYSRLYRTLANKVPALKDIVAEMEKGGVFKDVRS
What are the official names of this protein?
Kinesin-like protein KIN-14L.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.
Protein: BOXD_AROEV
Sequence: MKLANYVYGQWIEGAGEGAALTDPVTGEALVRVSSDGIDVARALEFARTAGGAALKALTYEERAAKLAAIAELLQAKRAEYFDISLRNSGATEGDASFDVDGAIFTVKSYARAGKALGAGRHLKEGGRVALAKTDVFQGQHFLMPLTGVAVFINAFNFPAWGLWEKAAPALLAGVPVFAKPATPTAWLAQRMVADVVEAGILPPGAISIVCGGARDLLDHVTECDVVSFTGSADTAARMRTHPNVVARSVRINIEADSVNSAILGPDAQPGTPEFDLAVKEIVREMTVKTGQKCTAIRRILAPAGVSRALADAVSGKLAGCKVGNPRSEGVRVGPLVSKAQQAAAFEGLAKLRQECEVVFGGDPDFEPVDADAAVSAFVQPTLLYCDKGLAARHVHDVEVFGPVATMVPYADTRDAVAIARRGHGSLVASVYSGDAAFLGELVPGIADLHGRVMVVDAAVGANHTGHGNVMPTCLHGGPRARRRRRGVGRSARAGDVSPPLRRAGRPRGAGSPVA
What is the function of this protein?
Catalyzes the NADP-dependent oxidation of 3,4-dehydroadipyl-CoA semialdehyde to form cis-3,4-dehydroadipyl-CoA.
What are the official names of this protein?
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: KDSA_RHOBA
Sequence: MTETPEIQPVRIRDYVCGPGEPLLVIAGPCVLQSRELALQIGEELARINQRSDVQVIFKASFDKANRTSLAAQRGPGIEQGLGLLEAVRANTGLPVTTDIHLPEQAAAVGEVCDLLQIPAFLARQTDLLVAAASTGRPVNVKKGQFMSPGDMRYVVDKLRGSGDGGVMACERGTFFGYGRLVNDMQAIPIMRSLGVPVVFDATHSVQQPGGLGGATGGNREMVEPLARAAVAIGCDALFFETHPDPQTSPSDGPNMIPLDRFAGTLDRLLRLREAVDGLDG
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2A7_DABPA
Sequence: MRTLWIVAVCLMGVEGHLTQFGDMINKKTGTFGLLSYVYYGCYCGLGGKGKPQDATDRCCFVHDCCYGTVNGCDPKLSTYSYSFQNGDIVCGDDDPCLRAVCECDRVAAICFGENMNTYDTKYMLHSLFDCMEESEKC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that is not toxic by itself, but the synergistical mixture of a basic and this acidic protein is lethal.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
What are the official names of this protein?
Acidic phospholipase A2 VP7, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL18_RUBXD
Sequence: MKVTRKRAQRERRHRRVRRKIFGTPERPRLSVYRSNVHTYAQLIDDIAGHTLAAADSREVGEAESRVEAARKVGELIASRAREAGIERAVFDRGGYKYHGRVAALAEGARAGGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: RL6_CLOBM
Sequence: MSRVGKLPVAIPNGVTVTVTPDNVVTVKGSKGELVKAMSNKINIAVEDNSVVVTRDNDHKDVRALHGLTRALINNMVTGVNEGYVKTLELIGVGYRAQLQGKKLVLSLGFSHPVEMEAVSGVEFEVEGGTKVKVKGIDKELVGAVAADIRKWRKPEPYKGKGIKYENEVIRRKEGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PYRG_PARP8
Sequence: MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFVERGAASATCGEPDVAIVEVGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTLVPFIATAGELKTKPTQHSVQKLREIGIYPNVLLCRADRRIPDDERAKISMFSNVPEDAVISVWDVDSIYKIPQMLHDQGLDELICEELKLTARPADLSIWSEMVEKLENPKSEVTIGMVGKYVELTESYKSLIEALRHASIHTSTKVNIEYIDSEELEENGVDSLKHLDAVLVPGGFGRRGTEGKIKAIRYAREAKVPYLGICLGMQLAVIEFARDVVGLKDANSTEFDQDTPNRVVALITEWYDREGKVEKRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRFVPQLEGGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKAFVEAARAHHEASVEEKV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: MCU_DROME
Sequence: MSRNRAAMVSAFRLFLRPATTTTHRSLALRLAPGTTFALHLRPCHELQQHRSFASTAEDGETDKHKKPTTGEDIYVEYVNGMPHMTVRLPSRNELCQFALKPISHNVGDLLAMLRAEDRGIDRAAVINKHGVRIASSCTIESLLDDSFSIQINNRTLDVNPPKRDKVTLESMDKVGDVRKVIAQLYEAFNVGEYQLEKSNQLAKELETLRYELEPLEEKKLELSKKAARRTNFMTWMGLGLMSVQFGILARLTWWEYSWDIMEPVTYFVTYGTTMAMYAYYCVTKREYMMEDVKNREFSLSLYRNAKKVQFDVEHYNELKRKSAELEYNLRRINDPLNMQLPSHLVRTQENTPPTLTEEKAERKYT
What is the function of this protein?
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:28726639).  Constitutes a pore-forming and calcium-conducting subunit (PubMed:28726639).  Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (PubMed:28726639).  Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer (PubMed:28726639).  During pupation, required for memory function in mushroom body neurons (PubMed:27568554).
What are the official names of this protein?
Calcium uniporter protein, mitochondrial, Mitochondrial calcium uniporter.
What is the protein family that this protein belongs to?
Belongs to the MCU (TC 1.A.77) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CRYAA_MELUS
Sequence: MDIAIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIYLDVKHFSPEDLTVKVLEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVPSGMDAGHSERAIPVSREEKPSSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: HEMH_THET2
Sequence: MNVLLMAYGTPYAPEEVEPYYTDIRRGRRPSEELLKELAERYEAIGKSPLNEITLAQAVRLQALLNLEAPPYPKRLLGPFPPRAPHGPARVYVGTKHWHPSIGEAVAAMHEDGVRRAVAIVAAPHYSLRSVAEYREKVDSALKTLPEPIDFVWVESYEAHPGLIAAYARRLEEVIWRLKNPGKAAYVFTAHSIPLSAVEKGDPYPRQVEKTAELIAKKLALPRFHVAYQSAGRTPEPWLGPDINELLRTLKEEGYEEVAVQAVGFPADHLEVFYDLDLEAQATARELGLRLLRARSLNADLDYIQVLKDLVEAAWPR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y275_CHLMU
Sequence: MLKILFHTMTLFGHLLSTPVYMVGDACGKDRDEYRNPPLKAFSIESQFLQIENADFKTLPNQSLGYRQTDTMFFATLPVTDMSGFLVSARYLGAEVLWKSSKDLQNTDPHALGYFAFQDKSFYQYVSLSAGAYTLALTNWQWSVLFSGMVDPENIEMGSGVYQVVLSSKYHASEAFAVVIGVINEVGLHDKQAWPLLGFSYKPEDKLTLNCIYPVNFSAEYQCTSVCDLGAAYRLTRFRKKFPKNSLTTSEGIFEYSGREIEGSVKLIFWPGQSLKVFGGYSVGNDISLTNPHNEDEKIYKFGSSLFFGGSANLHF
What are the official names of this protein?
Uncharacterized protein TC_0275.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0441/CT_007/TC_0275 family.
Protein: RS3_PROM3
Sequence: MGNKIHPTGLRLGITQEHRSRWYATSKMYPILLQEDDRIRRFIHKKYGAAGISDVLIARKADQLEVELKTARPGVLVGRQGSGIEELRTGIQKTIGDHSRQVRINVVEVERVDADAFLLAEYIAQQLEKRVAFRRTIRMAVQRAQRAGVLGLKIQVGGRLNGAEIARNEWTREGRVPLHTLRAEIDYATKVASTTYGVLGIKVWIFKGEVLGDEAQSMPVGASPRRRGNRRPQQFEDRSNEG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: SYI_CARHZ
Sequence: MDYGKTLNLPVTDFPMRGNLPEREPEILAYWQKIDLYRKVQQKNEGRPKFILHDGPPYANGDIHMGHVLNKVLKDMIVKFKSMDGYDAPYVPGWDTHGLPIEQRAIKDLGINRKEISPLEFRAKCREYAEKYARIQKEQFKRLGVRGDWENPYLTLMPHYEAKQIEIFGEMAKKGYIYKGLKPVYWCPVCETALAEAEIEYAEKKSPSIYVRFKVVEGKGKVPEDAYLVIWTTTPWTLPANVAIAVHPEFTYALVKTEKGDYVVAEGLVQQFFEATKLTGEIVARFKGEELLGVVTRHPFIERESPVVLADYVTLESGTGLVHTAPGHGTEDFETGKKYNLPVLSPVNHQGVFTEGAGKYAGMKIDDGNKAITQDLEASGDLLAMSFIKHSYPHCWRCKNPVIFRATEQWFASIDGFREQALKEIEKVEWIPAWGKDRIYNMVRDRGDWCISRQRTWGVPIPIFYCEACGKEIITDESIKAVSDLFRVEGSDAWWKYEAGEILPDGFRCPHCGGVKFRKETDIMDVWFDSGSSHAAVLEQPEYWPDLRWPADLYLEGSDQHRGWFNSSLSTAVATRGMAPYKAVLTHGFLVDEKGRKMSKSLGNVVDPLKVIKELGADILRLWVASADYRSDLAISNNILKQTAEGYRKIRNTIRFLLGNLYDYDHEKHRVPYERLLEIDRWALAKLHRLIARVVRAYRDYEFHVVFHAVHNFCTVDMSAIYLDIIKDRLYVELPDSEKRRSAQTVLYEILDSLLRLLTPILAFTTEEAYRHFPAKGKKESVQLLDMPKVEERYLDLTLEETWDKILEVRAKVLKALEIARQEKLIGHSLDAWVTLKASGELYDFLVERVNMWPEIFIVSQVDIQNEEVTGENGELPLEVVVNKALGEKCQRCWMYSPEVGLDPEFPDTCPRCAGVLHELKNRPL
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AVT1A_ARATH
Sequence: MEDKNNDKEKKTDVTFEDDEDNEDLEDNSSKYENDSETDQSDLGDLPGDAVDRDDDIDEPFISQVQWPQSFRETTDSYTIAASPIFGSLRSNPPSFYRASRSNLDVESKAPLLPERHDDSDKASATQSAWSHKGSFAEELPIGGYGCSVIQTIFNAINVMAGVGLLSTPYTVKEAGWASMVILLLFAVICCYTATLMKDCFENKTGIITYPDIGEAAFGKYGRILICMLLYTELYSYCVEFIILEGDNLTGLFPGTSLDLLGFRLDSKHLFGILTALIVLPTVWLKDLRIISYLSAGGVIATALIAVSVFFLGTTGGIGFHHTGQAVKWNGIPFAIGIYGFCYSGHSVFPNIYQSMADKTKFNKAVITCFIICVLLYGGVAIMGYLMFGEATLSQITLNMPQDQFFSKVAQWTTVVSPFTKYALLMNPLARSIEELLPERMSENIWCFLLLRTALVASSVCSAFLIPFFGLMMALIGSLLSILVAIIMPALCFIKIMGNKATRTQMILSSIIVAIGVVSGTLGTYSSVAKIIRNYQ
What are the official names of this protein?
Amino acid transporter AVT1A, AtAvt1A.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CRFR1_MACMU
Sequence: MARHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
What is the function of this protein?
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin).  Has high affinity for CRH and UCN.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase.  Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.  Inhibits the activity of the calcium channel CACNA1H.  Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress.  Plays a role in the response to anxiogenic stimuli.
What are the official names of this protein?
Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.
Protein: Y593_CAMJE
Sequence: MEINALTITTLYIIGISAEGMTGALAAGRHKMDLFGVIFIALVTAIGGGSIRDVLLGHYPLTWVKHPEYIILICFCALVATKIPRVVTKLETLFLTLDAIGLVVFSILGAQIAIDQNHGFIIAVAAAVITGVFGGILRDILCMRIPLVFQKEIYAGIAIIAGAIYYSLIIWLELNALVCTLLTLFIGVFARLLAIKYQWSLPIFSYNEEK
What are the official names of this protein?
UPF0126 membrane protein Cj0593c.
What is the protein family that this protein belongs to?
Belongs to the UPF0126 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL24_MYCA9
Sequence: MKVHKGDTVLVIAGKDKGAKGKVIAAYPERSRVLVEGVNRIKKHTPQSANERGASSGGIVTQEAPIHVSNVMVIDSDGQPTRIGYRVDEETGKKVRISRRNGKDI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SYE2_SULNB
Sequence: MLRFAPSPTGDMRTEQLRIAIFNYIVAKQKEVNFIVRIEDTDKERNITGKDTEILQILEKFAITHDSVFHQSEHLNIHQTLAIRLLEEGKAFVCTCTPEAPESDKTPSRYNGKCFNVDKEELKRLKEEKIPFVIRLKKPEHDMIIHDLYKGETVTSADEVDSFVILRADATPTENFASACDDMLSGIDFIIRSEEHLDETAKQEYVKKQLGYEEETTYAHLPVILNEEGQKMDEKDDAFTVKWLFEEGYIPDAIANYLISLGNTTPTDIFTLPEAIEWFNITKLSGSPVKFNIEELRLLNRKHLEKMDDKRLSSLFGFADADIGKLAKLYINEAATINELDARIKAIFSPKDFDGKWGEQMRMLEKIIAEAPMFATFEAFESHLMKESGLSGEYFSKPLRVLLTGAEQGPELSDIYPYIKSYLLEVAS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH1_MYCBO
Sequence: MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAVETVERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVFSAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1, HMBPP reductase 1.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: CCZ_ORYSJ
Sequence: MGLSSAAAGEGPQLCVFDLRRGQQEGQELDKILFFHPTDCPILLQLSVIGLCEGIITFARIFSPDDDCEVIESEKHSHVFYQAEADIWMVLVVEKNKDIESTWRCGALQGILKEVHSLFTMFHGPIRTLLDRQPSAELARGHLRTFFTDYLSDFNAGKKIQLPTFRDCLKERGTVQMLTISREVALEVQSLTTVLGSCLGNVMCQSLVLFEDLLVSTTLPPDDTLNLYTYAILRLTPRALLSNATSWSYLRKGTSVHAGPTSSSSNGTASVERPLQREKLYKGKDGFVAAGSTTSEVRGAVAWVPILWFQQAEDRMHLCVYQHKNITILLLIPASSLINGDDGIAHVKRHLLENASQNIVTLELKLSRGWGGENAYHVGGYRYLLVDPDRKVSRASPPGKVTTLSKDSLLSLNRLREEIDLEKSRAKRSDSCHDKDFEVCIRAKNNAWVIAKVTRGRELYMALEKAGETLLYASTAIEKFSNRYCEGAFSTD
What is the function of this protein?
Plays an important role in membrane trafficking through the secretory apparatus.  In complex with MON1, acts as a guanine exchange factor (GEF) for Rab7 protein family.  Promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.  The active form is involved in protein trafficking from prevacuolar compartments (PVCs) to vacuoles.  May serve as a linker between Rab5 and Rab7 protein families in PVCs and mediate PVC maturation.
What are the official names of this protein?
Vacuolar fusion protein CCZ1 homolog.
What is the protein family that this protein belongs to?
Belongs to the CCZ1 family.
What are the subcellular locations of this protein?
Endosome. Prevacuolar compartment.
Protein: SSR5_MOUSE
Sequence: MEPLSLTSTPSWNASAASSSSHNWSLVDPVSPMGARAVLVPVLYLLVCTVGLGGNTLVIYVVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYWPFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKLASAAVWVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKALCLRRGYGVEDADAIEPRPDKSGRPQTTLPTRSCEANGLMQTSRL
What is the function of this protein?
Receptor for somatostatin-28.  The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.  Increases cell growth inhibition activity of SSTR2 following heterodimerization.
What are the official names of this protein?
Somatostatin receptor type 5, SS-5-R, SS5-R, SS5R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.