PharMolix/UniProtQA huggingface dataset:
Protein: CH60_HAHCH
Sequence: MAAKDVKFGDSARKRMVAGVNTLADAVKVTLGPKGRNVVLDKSFGAPTVTKDGVSVAKEIELKDKFENMGAQMVKEVASKTNDEAGDGTTTATVLAQAILNEGLKSVAAGMNPMDLKRGIDKAVIAAVKEIKNISRPCEDSKSIAQVGTISANSDERIGNIIAEAMEKVGKEGVITVEEGSGLEDELDVVEGMQFDRGYLSAYFVNNQDSMSAELEDPFILLVDKKISNIREMLPVLEAVAKSSKPLLVISEDLEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKEMLQDIAILTGGTVISEEVGLNLEGATLDDLGTAKRVVVTKENTTIIDGAGAKSDIEARVAQIRRQIEETSSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHSTRAAVEEGVVPGGGVALVRALQAVSDLAGDNADQDVGINLLRRAMEAPLRQIVANAGGEPSVVVDKVRQGEGAFGYNAGTEAYGDMLEMGILDPAKVTRTALQSAASIAGLMITTECMVSDLPEDDKKGGMPDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_SACD2
Sequence: MIPTLALVGRPNVGKSTLFNRLTRSRDAIVANFSGLTRDRQYGEATHGDKRFIVVDTGGISGEEEGIDSYMAGQSLQAIEEADMVAFIVDARVGLTAADMQIAQHLRTCNKPIFLLANKVDGVNESIVCAPFFELGLGDVIGIAAAHGRNINTMLDTVLENVEPEAEASEEDKAKGIKLAIVGRPNVGKSTLVNRMLGEDRVVVYDMPGTTRDSIYIEYERDGKAYTIIDTAGVRRRKNIKLSVEKFSIVKTLQAIDDANVVILVMDAQEGIVDQDLHLMGHVIDSGRALVVALNKWDNLDNDHKSYVKTELSRRLQFVDFADLHFISALHGTGVGDLYKSVHKAYSSATEKLNTNFLTKILEFAVSQHQPPLVNGRRIKLRYAHAGGQNPPIIVIHGNQTAAVPKNYVRYLEKIFRKELELHGTPIRFEFKSSENPFAGRKNAMSKKPEHPSRRANSGGKSINRRPRPKS
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: NOB1_MOUSE
Sequence: MAPVEHVVADAGAFLRDAPLQDIGKNIYTIREVVREIRDKATRRRLAVLPYQLRFKEPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKKEPEKAKVSSSIQHPETALHISGFHLPSKSKPLQEAVDRGHAADGPENLEFSSFMFWRTPLPNIDRELQELLIDGREEEEEEEECEDSDDDGGGWITPSNIKQIQQELEQCDTPEDVQVGCVTTDFAMQNVLLQMGLHVLAVNGMLVREARSYILRCHGCFKTTSDMNRVFCGHCGNKTLKKVSVTINDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTDVFAPDYIAGVSPFAENDISSRSAILQVRDGMLGAGRRRLNPNASRKKFVKKR
What is the function of this protein?
May play a role in mRNA degradation (By similarity).  Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
What are the official names of this protein?
RNA-binding protein NOB1.
What is the protein family that this protein belongs to?
Belongs to the NOB1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SOAT_MOUSE
Sequence: MSTDCAGNSTCPVNSTEEDPPVGMEGHANLKLLFTVLSAVMVGLVMFSFGCSVESQKLWLHLRRPWGIAVGLLSQFGLMPLTAYLLAIGFGLKPFQAIAVLMMGSCPGGTISNVLTFWVDGDMDLSISMTTCSTVAALGMMPLCLYIYTRSWTLTQNLVIPYQSIGITLVSLVVPVASGVYVNYRWPKQATVILKVGAILGGMLLLVVAVTGMVLAKGWNTDVTLLVISCIFPLVGHVTGFLLAFLTHQSWQRCRTISIETGAQNIQLCIAMLQLSFSAEYLVQLLNFALAYGLFQVLHGLLIVAAYQAYKRRQKSKCRRQHPDCPDVCYEKQPRETSAFLDKGDEAAVTLGPVQPEQHHRAAELTSHIPSCE
What is the function of this protein?
Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:23562556).  Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (By similarity).  May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (PubMed:23562556).  May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (By similarity).  Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (By similarity).
What are the official names of this protein?
Sodium-dependent organic anion transporter, SOAT, Solute carrier family 10 member 6, SLC10A6.
What is the protein family that this protein belongs to?
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: DAPF_SODGM
Sequence: MQFSKMHGLGNDFMVVDAVTQNVYFSPEMIRRLSDRHCGVGFDQLLVVEPPYDPELDFHYRIFNADGSEVAQCGNGARCFARFVRMKNLTNKRDIHVSTQTGRMVLTVTEDDSVRVNMGEPNFDPQQVLFRAARVEKTYIMRAAEQTVLCGVVSMGNPHCVIAVDSVDNAPVATLGPVLESHERFPERANIGFMQVLNRGHIRLRVYERGAGETQACGSGACAAVAVGISQGQLAEQVQVELTGGRLAISWRGPGHPLYMTGPATHIYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P8_RDVA
Sequence: MSRQMWLDTSALLEAISEYVVRCNGDTFSGLTTGDFNALSNMFTQLSVSSAGYVSDPRVPLQTMSNMFVSFITSTDRCGYMLRKTWFNSDTKPTVSDDFITTYIRPRLQVPMSDTVRQLNNLSLQPSAKPKLYERQNAIMKGLDIPYSEPIEPCKLFRSVAGQTGNIPMMGILATPPAAQQQPFFVAERRRILFGIRSNAAIPAGAYQFVVPAWASVLSVTGAYVYFTNSFFGTTIAGVTATATAADAATTFTVPTDANNLPVQTDSRLSFSLGGGNINLELGVAKTGFCVAIEGEFTILANRSQAYYTLNSITQTPTSIDDFDVSDFLTTFLSQLRACGQYEIFSDAMDQLTNSLITNYMDPPALPAGLAFTSPWFRFSERARTILALQNVDLNIRKLIVRHLWVITSLIAVFGRYYRPN
What is the function of this protein?
Capsid protein which self-assembles to form the outer icosahedral capsid with a T=13 symmetry, about 70 nm in diameter and consisting of 780 molecules capsid proteins.
What are the official names of this protein?
Outer capsid protein P8, Structural protein P8.
What is the protein family that this protein belongs to?
Belongs to the phytoreovirus outer capsid protein P8 family.
What are the subcellular locations of this protein?
[Outer capsid protein P8]: Virion. Host cytoplasm. Note=Found in the peripheral regions of spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: SYS_SYNE7
Sequence: MLDLRLLRENPEATQARLDRRHSSYDIQPLLSLDQQVRQWEQERTQLQARSNEIGRSVGQKMREGADPQSEEIAALREEGNQLKQQIADLEQQERQVRSELDTYLLTLPNLPDETVPLGSSEDENREIHRWGDDRIREGEFAPHWEIGERLGLFDFERSTRIAQSRFVTLLGAGAALERALIAFMLDRQTAAGYTEVAPPYLINSASLTASGQLPKFSEESFRCDRDDLWLTPTAEVPLTSLYRDEILSADQLPLRYCAYTPCFRREAGSYGRDTRGLIRLHQFNKVELYQFVHPDHSEAAHQQLLANAEAILQALELPYRTIELCTGDLGFSAQKTYDIEVWLPSAGRYREISSCSNCGDFQARRANIRFKEAGQKGTRFVHTLNGSGLAVGRTMAAVLENYQQPDGSVRVPEALQPYLRQTVIGQP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_RHIME
Sequence: MAQERRGSREDRQNREERDSEFVDKLVAINRVAKVVKGGRRFGFAALVVVGDQKGRVGFGHGKAREVPEAIRKATEAAKRDLIFVPLRGGRTLHHDVHGRHGAGKVLLRSAKPGTGIIAGGPMRAVFETLGVHDVVAKSTGSSNPYNMVRATFDALKNQMHPKDIAAQRGMKYATLQSRRVSAGVASEE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: FRIL_PONAB
Sequence: MSSQIRQNYSTDVEAAVNSLVNMYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKREGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSAHTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
What is the function of this protein?
Stores iron in a soluble, non-toxic, readily available form.  Important for iron homeostasis.  Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.  Also plays a role in delivery of iron to cells.  Mediates iron uptake in capsule cells of the developing kidney (By similarity).
What are the official names of this protein?
Ferritin light chain, Ferritin L subunit.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.
Protein: MFAP4_BOVIN
Sequence: MEALLVLPLLLLLSAGPCAPQLLGIRGDALEKSCLQLPLDCDDIYAQGYQADGVYLIYPSGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWNDYKLGFGRADGEYWLGLQNMHLLTLKQKYELRVDLEDFENNTAFAKYADFSISPNAVSAEEDGYTLYVSGFEDGGAGDSLTYHSGQKFSTFDRDQDLFVQNCAALSSGAFWFRSCHFANLNGFYLGGSHLSYANGINWAQWKGFYYSLKRTEMKIRRA
What is the function of this protein?
Could be involved in calcium-dependent cell adhesion or intercellular interactions.  May contribute to the elastic fiber assembly and/or maintenance.
What are the official names of this protein?
Microfibril-associated glycoprotein 4, 36 kDa microfibril-associated glycoprotein, 36 kDa MAP.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PSBM_ORYSA
Sequence: MEVNILAFIATALFILVPTAFLLIIYVKTVSQND
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: YWIS_WHEAT
Sequence: MDRNHAARNSAPLPLSAAHILLPSPSLSSPAPSPQLRSLSCTTSAAATPVPVPHHCLRCCDPPPPPPPPTPSPSISLLPFPFSDGPRLALNPVIPDDHFSSEMDTTTGGALRCRNQHLFLLQPAGQNAGTGPAQKLKTDETRCYERRGGSQ
What are the official names of this protein?
Uncharacterized 16 kDa protein in middle repetitive insertion sequence WIS1.
Protein: Y916_MYCBO
Sequence: MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVCIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDGRWVLRTDSGTESTVDFLISATGVLHHPRIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGSTGVQLVCGLAGVAGKVTMFQRTAQWVLPWPNPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAVCRASLRRVRDPRLRRALTPDYEPMCKRLVMSGGFYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYLNKDGIPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA
What are the official names of this protein?
Uncharacterized monooxygenase Mb0916.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: SSR2_RAT
Sequence: MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
What is the function of this protein?
Receptor for somatostatin-14 and -28.  This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.  In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins.  Inhibits calcium entry by suppressing voltage-dependent calcium channels.  Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion.  Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B.  Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development.  Mediates negative regulation of insulin receptor signaling through PTPN6.  Inactivates SSTR3 receptor function following heterodimerization.
What are the official names of this protein?
Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R, SRIF-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Protein: NDHJ_LOTJA
Sequence: MQGRLSAWLVKHGLVHRSLGFDYQGIETLQIKPEDWHSIAVILYVYGYNYLRSQCAYDVSPGGLLASVYHLTRIECGIYQPEEVCIKIFVPRNNPRIPSIFWVWKSADFQERESYDMLGISYDNHPRLKRILMPESWIGWPLRKDYITPNFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RL18_DESRM
Sequence: MLTKPDRKAIRAKRRRRVRNKILGTAARPRLNVFRSLNNMYAQLIDDETGVTVVAASTLSPELKETFKNGGNVEAAKAVGDLVGKLALEKGIKEVVFDRAGYLYHGRVKALAEAAREAGLDF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CHRD1_CHICK
Sequence: MSLLCYNRGCGQRFDPETNTEDSCTYHPGVPVFHDALKGWSCCKRRTTDFSDFLSIVGCTKGLHNSEKPPEPVKPDVKSTTERKELAELKPKFQEHIIQAPKPLETIKRPSPDEPMTNLQLKVSASLKQALDKLKLSSENEEKKEEDSDEIKIGTPCKNAGCSKTYQGPHSTEEVCQYHSGVPIFHEGMKYWSCCKRKTSDFNTFLAQEGCTTGTHVWTKKDAGKKVVPCRHDWHQTGGEVTVSIYAKNSVPDLSYVEANSTMLNIHIVFEGEKEFHRNVKLWGVIDVKRSYVNMTATKIEVSMRKAEPLLWASLELPVSNTQQTNENSDQ
What is the function of this protein?
Regulates centrosome duplication.
What are the official names of this protein?
Cysteine and histidine-rich domain-containing protein 1, CHORD domain-containing protein 1, Protein morgana.
Protein: RL35_CLOD6
Sequence: MPKMKTHRGAAKRLKKTGTGKLKRAKAFKKHILTKKSAKTKMNLRKSTLVSDGDAKRIAQLLPY
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: PYRG_CERS5
Sequence: MARYVFITGGVVSSLGKGLASAALGALLQARGFSVRLRKLDPYLNVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERFTGVSARKTDSVSSGRIYSNVLEKERRGDYLGKTIQVIPHVTNEIKDFLRVGEDEVDFMLCEIGGTVGDIEGLPFFEAIRQFAQDKPRGQCIFVHLTLLPYVSASHELKTKPTQHSVKELRSIGIAPDVLLLRSEHPIPEKEREKIALFCNVRKEAVIAAYDLKTIYEAPLAYHREGLDQAVLDAFGISPAPKPNLDRWVDVMDRLEHAEGEVRVAIVGKYTQLEDAYKSIAEALTHGGMANRTRVRAEWINAELFEREDPSPFLEGFHAILVPGGFGERGTEGKIRAAQYAREKGIPYLGICLGMQMAVIEAARNLAHVKDAGSEEFDHEIGRKRYTPVVYHLKEWIQGNHIVERKHDDDKGGTMRLGAYTAALAAGSRVATIYGSTEIEERHRHRYEVDVRYREALEGCGLTFSGMSPDGRLPEIVEIKDHPWFVGVQFHPELKSKPFAPHPLFADFIRAAVEVSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: HLY2_ACTPL
Sequence: MRTRSRSTVRPLWPPPSPARFATWSHYRLRDHGDHTRPVDPRSAGTQVDDEVLEERVAYNLSKDAQLKEEARINVVAYNGKVLLIGQAPTMSASESAKNLAAGAEGVTEIYNEIRTGEKIGVGQISIDSWITTAIKSKLLANSEVKATEVKVITENGEVFLIGKLSPAQADAAAEVARNVRGVNKVIKVINYVQ
What are the official names of this protein?
21 kDa hemolysin.
What are the subcellular locations of this protein?
Periplasm.
Protein: DNAA1_CHLPN
Sequence: MRAWEEFLLLQEKEIGTNTVDKWLRSLKVLCFDACNLYLEAQDSFQITWFEEHIRHKVKSGLVNNNNKPIRVHVTSVDKAAPFYKEKQMQQEKTAYFTMHYGSVNPEMTFSNFLVTPENDLPFRVLQEFTKSPDENGGVTFNPIYLFGPEGSGKTHLMQSAISVLRESGGKILYVSSDLFTEHLVSAIRSGEMQKFRSFYRNIDALFIEDIEVFSGKSATQEEFFHTFNSLHSEGKLIVVSSSYAPVDLVAVEDRLISRFEWGVAIPIHPLVQEGLRSFLMRQVERLSIRIQETALDFLIYALSSNVKTLLHALNLLAKRVMYKKLSHQLLYEDDVKTLLKDVLEAAGSVRLTPLKIIRNVAQYYGVSQESILGRSQSREYVLPRQVAMYFCRQKLSLSYVRIGDVFSRDHSTVISSIRLIEQKIEENSHDIHMAIQDISKNLNSLHKSLEFFPSEEMII
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA 1.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FICD_DROMO
Sequence: MAMATGKATEEEQPEQGQQQQQLQQQQKQTTLQSTYRFALFFIAGCLAAFGFHALTSSSGSLLGWRLRLHHLPTAHYLQTRDEFAVYSVDELNAFKEFYDKSVSDSVGASLSEAEETNIKEAMGALRLAQEMYMTGKDDKAARLFEHALALAPKHPEVLLRYGEFLEHNQRNIVLADQYYFQALSINPSNTEALANRQRTADVVQLLDERRLSSLDEKRDALSAIHEANSALRRAKKEAYFQHIYHSVGIEGNTMTLAQTRSVLETRMAVDGKSIDEHNEILGMDLAMKYINASLVQKLYITLKDILELHRRVLGHVDPIEGGEFRRNQVYVGGHIPPGPGDLAILMQRFEHWLNSEQSNSLHPVNYAALAHYKLVHIHPFVDGNGRTSRLLMNTLLMRAGYPPVIIPKQQRSQYYHFLKLANEGDIRPFVRFIADCTEKTLDLYLWATSDLPQQIPMLIQTESDGNVLAQLQSHTSSPELYESGSGSGAGAGAGSGQKGMP
What is the function of this protein?
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity).  The side chain of Glu-251 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity).  Acts as a key regulator of the unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of Hsc70-3/BiP.  In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of Hsc70-3/BiP at 'Thr-518', thereby inactivating it.  In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from Hsc70-3/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity).
What are the official names of this protein?
Protein adenylyltransferase Fic, De-AMPylase Fic.
What is the protein family that this protein belongs to?
Belongs to the fic family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: TOPZ1_MACMU
Sequence: MRRPPPLGPTTASGPEGNVRNLRKRQAPGPGAAGGCGPEAGGRGENRQKRRMVARATPGRGEVKSDKSVAASGAGKAARRRVEGRRGQVSPSDRRGLEAAKEAEFPLQTERHTKEKRKVTEASTDDPQPGFDLVRKESLTSSESFQTVECLRSLGKEGIVEGIKRRIRNKKLKSLENPPLKITENEATQNIKVEFQDELYKNTLKYSCNILSPEVENNFVFKLRDCNCFPHSKDCNDENNLPYEPDGGCMHVAENFSKKENFRSLAEKSDTNNIPQLLQTEENVMGVNKLLPEESDLYQSKINGLLPCLQREKNKYSIEESSVGRKPRKRMKLSEKADETVTQMNFSNEYNKSELMLQENQMIADGKEAEAKSPLNVLRKVSHNTVSLMDHLLSVPEMVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYENMALKEDFKSKSCIGKSPEYHIERRSSREDLRSDSEELKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLPGSQKSCKKVDVPKHQTNKTHLTDSKLLLQSSLTETNTESSSKEKLDSNLNCLFSVSAVEHTLMVIKEPIIKDDKKIKSEELSRSGSEVISNTTEDTQLTSDTQSLTGNKKRDRGNLTKLNLTAASKDGQEANNSTGKTIHRKACVAKQTFVVPDLVKILNTGRLTNFKIPLLKNKTKKRKEVNAKSSEREAYSPLELLDNLSGADTRQNRSKENVSMTMLGPQTLSIQNSVTPVQASSDSFYNKNSCSISPSFTKHGNSSKPSNHFSEPGNIVSNKEVASLTVENNAFSSDPGYVEKSPSFCCNKQETFRPVSSEVRGRKITKNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSFTSEVPRISQEPNVPGEHQLTDSKYVETPVKKEPSDDLRELPVLDCGPIKPDICASNSAASEIRHDPKDANTSLGEVANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVRKSKDSRNADIMVGECQFAAPVPKPLCLLVPPLNLSGHQEDTILNTWMNDFRFLGKHSVLKLQNPETCEIFKREKNVGVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELCLLQRAVNVFMEYYRKFPPGIYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLKILLNIFEHVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAVLEMKSRLQMRQFKKNWKCDLDSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNCEDERPDTPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSKGRKVLDKLYELKIHFASLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGALWVMRESEWIIDTPLWPCDRLDVLNRHNLLCTIAHETLAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSLLFNKLLGSCIESNSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSRLWLKARAHYKSALSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKRCEDNQSRSNDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENMKWAGKVWLFSNH
What is the function of this protein?
Important for normal spermatogenesis and male fertility.  Specifically required for progression to the post-meiotic stages of spermatocyte development.  Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
What are the official names of this protein?
Protein TOPAZ1, Testis- and ovary-specific PAZ domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: GLMU_SALHS
Sequence: MLNSAMSVVILAAGKGTRMYSDIPKVLHTLAGKPMVQHVIDAATKLGAAQVHLVYGHGGELLKQTLKDDKLNWVLQAEQLGTGHAMQQAAPFFSDDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPSGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLSKLTNNNAQGEYYITDIIALAYQEGREIAAVHPARISETDGVNNRLQLSRLERIYQAEQAEKLLLSGVMLRDPARFDLRGTLHCGMDVEIDANVIIEGYVTLGHRVKIGAGCIIKNSVIGDDCEISPYSVVEDAHLEAACTIGPFARLRPGAELLAGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTVIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVADNELVLSRVPQVHKQGWQRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.