PharMolix/UniProtQA huggingface dataset:
Protein: GSFB_PENAE
Sequence: MASNTSRSAHLAQIITENTANIETYRREQGLPPLSLGPDAPLDVKYPPNVEKCRRAVIDATLELGELATGPVELRLVPGWAIMTMFGVTQFICDFDIARQIPLAGDISYEDLSKAINVAVPVLRQVLRAGMPYHMFYESRPGHVAHTATTKVMASESLISDWTSLYTDVLFPASAGLSKALREEPTASDPSKTGFMVTKGDGESGMYMYFEKHPEEARRFAGVMEAFQKDEAYAVRHLTDSWPSDSQTGKLVDLGGSTGAVAFALAEKFPGLEIVVQDLPGALEAAHVREGKNVSFMPHDFFNEQPVKDADVYMFRWILHNWPDGHVQRILRALVPSLKPGAKVIVFDEIMPPAGTLPLSIERYQRNIDFGMLTLFNSKIRDIVEWKEIITQSDQRFNVTGVRYPENSRLSLIEIVWQP
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections (PubMed:20534346, PubMed:23978092).  The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units (PubMed:20534346, PubMed:23978092).  The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone (PubMed:23978092).  However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C (PubMed:23978092).  Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B (PubMed:23978092).  The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin (PubMed:23978092).  Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin (PubMed:23978092).
What are the official names of this protein?
O-methyltransferase gsfB, Griseofulvin synthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: MURQ_RIPO1
Sequence: MDQLEERGHLLTEQINPKSRNLDQLTPLELVDLFNQEDAQTLRAIAQARQELAQAIEITAQALGRGGRLFYVGAGTSGRLGVLDAAECPPTFCTHPDLVQGIIAGGAAALVRSSENLEDRPEDGASAIAQRHIIDKDVVVGISAGGTTPFVHGAIEAAKQRGAKTIAMSCVPIEQVPIIVDIDIRLLTGPEILAGSTRLKAGTVTKMALNILSTGVMVCLGKVYGNRMVDVSVTNRKLHDRALRMLQDLTDLSREEAGFLLERSGRKVKLALLMHWTGLDAQMGQELLNNYHGNLRNAVQGYKTNV
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: GLKA_PYRAB
Sequence: MSWDEMYRDAYERVLNSIGKIKGVMLAYNTNIDAIKYLKREDLERRIEEAGKDEVLRYSDELPKKINTIQQLLGSILWSVKRGKAAELLVEDREVRNYMRQWGWDELRMGGQVGIMANLLGGVYGIPVIAHVPQISKLQASLFLDGPIYVPTFEEGLKLVHPRNFEGNEEDCIHYIYEFPRGFKVLNFTAPRENRFIGAADDYNPRLYIRKEWVERFEEIAERAELAIVSGLHSLTEETYREPIKVVREHLKVLKDLNIKTHLEFAFTADEKVRREILGLLSLVYSVGLNEVELASVLEIMNERELADRILAKDPADPVAVIEGLMKLIEEGVERIHFHTYGYYLAITKYRGEHVRDALLFSALAAATKAMLGNIEKLDDLRKGLEVPIGRQGLEVYEVVKREFNVEKGIGEVGDYQIAFVPTKIVEKPKSTVGIGDTISSSAFVSEFSLSS
What is the function of this protein?
Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
What are the official names of this protein?
ADP-dependent glucose/glucosamine kinase, ADP-dependent glucokinase, ADP-GK, ADPGK, Glucosamine kinase, GlcN kinase.
What is the protein family that this protein belongs to?
Belongs to the ADP-dependent glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_NOSS1
Sequence: MSISIRPDEISSIIQQQIEQYDQEVKVANVGTVLQVGDGIARIYGLEKAMAGELLEFEDGTVGIAQNLEEDNVGAVLMGEGREIQEGSTVTATGRIAQIGVGEALIGRVVDALGRAIDGKGDIKASESRLIESPAPGIIARRSVHEPMQTGITAIDSMIPIGRGQRELIIGDRQTGKTAIAIDTIINQKGEDVVCVYVAIGQKASTVANVVQTLQEKGAMDYTVVVAAGASEPATLQFLAPYTGATIAEYFMYKGKATLVIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLSDELGKGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLSSDLFNAGIRPAVNPGISVSRVGSAAQTKAMKKVAGKIKLELAQFDDLQAFAQFASDLDKATQDQLARGQRLRELLKQSQNQPLSVAEQVAILYAGINGYLDDIPVDKVTTFTKGLRDYLKSGVNPYFQDVQSKKALGDDEEKALKAALEDYKKTFKATA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: PYRH_SULIK
Sequence: MNIILKISGKFFDEDNVNNLIVLRESIRELTDNGFRVGIVTGGGSTARRYIKLAREIGIGEAYLDLLGIWASRLNAYLVMFSLQDLAYMHVPQSLEEFIQDWSHGKVVVTGGFQPGQSTAAVAALVAEASSSKTLVVATNVDGVYEKDPRVYTDVKLIPHLTTQDLRKILEGSQSVQAGTYELLDPLAIKIVERSKIRVVVMNYRKLNRIINILKGEEVSSIIEPT
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC11_KOMPG
Sequence: MNIRQQLVQLLNLAMVLSTAFMFWKGLGLVTNSNSPIVVVLSGSMEPAFQRGDILFLWNRDKYVDIGDVVVYEVKGKPIPIVHRVLREHKVTNKDRKVRQLLLTKGDNNPTDDLSLYAHKSNYLDRDEDVLGTVKAYLPKVGYVTILITENKYAKLGLLGLMALSTLLTRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RNPA_KINRD
Sequence: MLSAEHRLRHKDDFTVALKNGARAGTRRLVLHWAVTDRAHPTRVGFVVSKAVGGSVVRHRTQRRLRHVAAGRLTTLPALGGLLVVRALPAAGTATSAELAVDVDRGLRRLGLVATGAGDG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: COBQ_CROS5
Sequence: MKAMMVVGTTSHAGKSFITTAICRILARRGWHITPFKGQNMALNAYVTTTGGEIGYAQAVQAWAAGINPRVEMNPILLKPQGNMTSQVILGGKAAGITTATNYYEQYFDKGWNMIVHSLERLAVEYDFVVCEGAGSPAEINLKHRDLTNMRVAKYLNAPTLLVVDIDRGGAFAHVVGTLQLLDESERALIKGIVINKFRGQRSLLDSGIEWLENYTGIPVLGVIPWREISFSAEDSLDLLERRRKEQKEINVTILRLPHIANFTDFEPLDAEKTVSISYLDLNEPLGYPDAVIIPGSKTTINDLIALHESGIAKQLQDYVAAGGIVLGICGGFQMLGEMVFDPDQLEGNNVSYAGLNLLPIETVITPEKIVRQRHTCSVYPYPGFPITGYEIHQGVTRSSKSPHQRIKTTNHPLFEDGSLGIVNDNQSVWGCYLHGIFDNGAWRRNWLNYLRNRRGLPSLPTGIANYREQRETVLNQLADLVEQYIDLTPLLNN
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: GRAM4_HUMAN
Sequence: MLRRLDKIRFRGHKRDDFLDLAESPNASDTECSDEIPLKVPRTSPRDSEELRDPAGPGTLIMATGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNAEMLRQELDRERQRRMELEQKVQEVLKARTEEQMAQQPPKGQAQASNGAERRSQGLSSRLQKWFYERFGEYVEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTVYMNAVWHGWAIPLFLFLAILRLSLNYLIARGWRIQWSIVPEVSEPVEPPKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERSSAAVSRRLQTTSSRSYVPSAPAGLGKEEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGIAVSTPSTQKPLVFGAMVHRDEAFETILSQYIKITSAAASGGDS
What is the function of this protein?
Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177).  Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53.  Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity).
What are the official names of this protein?
GRAM domain-containing protein 4, Death-inducing protein.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with COX4I1.
Protein: SYL_BACCR
Sequence: MSFNHQEIEKKWQGYWEENKTFRTPDETEKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNSPAEFTEHNINTFRNQIKSLGFSYDWDREVNTTDPNYYKWTQWIFLKLFEKGLAYVDEVPVNWCPALGTVLANEEIIDGKSERGGHPVERRPMRQWMLKITAYGDRLLEDLDELDWPESLKDMQRNWIGRSEGAEVHFNIDGTDEKFTVFTTRPDTLFGATYCVLAPEHALVAEITTAEQKEAVEAYINAVKMKSDLERTELAKEKTGVFTGAYAVNPVNGEKLPIWIADYVLATYGTGAVMAVPAHDERDYEFASVFNLPMKEVVKGGDITKEVYTGDGAHVNSAFLDGLNKEEAIAKMIEWLEATSAGNQKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMTAVKEEELPLVLPKTENIRPSGTGESPLANIDEWVNVVDPETGKKGRRETNTMPQWAGSCWYYLRYIDPNNSEALVDPEKVKQWLPVDIYIGGAEHAVLHLLYARFWHKVLYDIGVVPTKEPFQQLFNQGMILGENNEKMSKSKGNVVNPDDIVASHGADTLRLYEMFMGPLDASIAWSENGLDGARRFLDRVWRLFVQDNGELSEKITDAPNKELEKAYHQTVKKVTEDYAELRFNTAISQMMVFINDAYKAETLPREYVEGFVKMIAPVAPHIGEELWSKLGYNETITYASWPTFDESKLVEDEVEIVVQVMGKVRAKLTMSKDASKEEMEQLALEAIQDQIEGKTVRKVIVVPGKLVNVVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXB_SERP5
Sequence: MQNRPLTIGLVAGETSGDILGAGLIRALKAQIPDARFVGVAGPLMQAEGCETWYEMEELAVMGVVEVLERLPRLLKIRKDLTRRFSDLAPDVFVGIDAPDFNITLEGRLKQRGIRTIHYVSPSVWAWRQKRVFKIGKATDLVLAFLPFEKAFYDRFNVPCRFIGHTMADAMPLQPDKLAARAKLGIAADARCLALLPGSRGAEVEMLSADFLKTAQLLRTRYPELELVVPLVNAKRREQFERIKAEVAPELRVHLLNGQGREAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWIAQRLVKTPYVSLPNLLAGREIVTELLQHDCVPDKLAASVMPLLEDSPQTDELKQTFLTLHQSIRCGADEQAAQAVLELAKA
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: P18_LEITA
Sequence: MRRLSSQLMCTAAAVRFASAGGAKKYDLFGYEVDTNTAPWIEKVKKCRYYDEAGEVLVSMNVKNCPPDLETYNATLQKIFEAPSKQEKPVENESKFCAMMDLMEEMQHRNKVKPNEESWTWVMKECVQSGQFRLGYCVAKLMEAEFKRVPEDLVKQNEANAAKAKADGKEHPSTLAQQQSLFDIKIQ
What is the function of this protein?
Putative RNA-binding protein.
What are the official names of this protein?
Protein P18, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: PAKE_DICDI
Sequence: MEEDKDSDTLQILNDIINNEPNLEIYVKSKNNNYISSRELPTQDSSTKTSNITTPNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTPTSLNSSWKSVVPKRKIDTSSGAILNNNNNVGSPNNQSTSQTNHQQPPPQQLQQQQSLSSTSTPSISPPMLSPSRRNVTSPNLTRSDPTVPITNSRPTSPLTPPLSPQFQLNNLNFDDNNDHSTTTTNNNNNNNNNNSNNNNNNNRPKLMRENSINKRSSLQTLPVSSSSSSSAEDEILIKVWLPMEYTGQLYKVRKFSGGSSTLKVSSMLNSQLSPMYQSPKNKLFLNNEEKPIPSHLTLKDLSLSKYDILYLRREPEYELIIPSSPQCGSLVMDKDIKIDDMLIKIEHWLKDILDHAPHSTSQQQQQQLQQQPILHVDKHEYFTSLEDQQLMSGHITNSSQYTLLKKLSVPTSNSRQTGKMSRGYYLRLYDQKPISNYGIKIKDTLIFKKKILNRGLSIDDAEGGIEITVLYSPLSMLPTTSDLDFEKELKENQQQLNNNNNNNNNNNNNNNNNNNNNNNNITTTTTTTTSSLINQTNEILLPNLIKIDNTSLLQDIKNEKKKRKSKRTPSSVGLPFNIIHKTHVDFEYKWSGTSVEDTFEFKEKLGQGGYGAVFKVLHRETNFPLAIKVLSITPTRIKDIEKEIDLLKKCRCPNVLSYYGSISSKLTELWILMDHCAVGSINDMMKICCDTLDEEQIAVVTLNVLNGLGYLHSKGIVHLDVKAANILLTEDKQIKIADFGVSQQLQTEYGQANVYIGSPLYMAPEVILKAPYNSKADIWSLGITLIELAEGRPPNRGLRSMNQLVEIPNMPPPKLSNPKDWSPCFNNFLATCLVKDPVQRPSVIDLLSHDFIKNAKTTEVLSNLVKQTLSSRQSI
What is the function of this protein?
May play a role in responding to changes in chemoattractant levels.
What are the official names of this protein?
Serine/threonine-protein kinase pakE.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein: KDPB_ECOLC
Sequence: MSRKQLALFEPTLVVQALKEAVKKLNPQAQWRNPVMFIVWIGSLLTTCISIAMASGAMPGNALFSAAISGWLWITVLFANFAEALAEGRSKAQANSLKGVKKTAFARKLREPKYGAVADKVPADQLRKGDIVLVEAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGTRILSDWLVIECSVNPGETFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATLWPFSAWGGNAVSVTVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGDVDVLLLDKTGTITLGNRQASEFIPAQGVDEKTLADAAQLASLADETPEGRSIVILAKQRFNLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVEANGGHFPTDVDQKVDQVARQGATPLVVVEGSRVLGVIALKDIVKGGIKERFAQLRKMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLIEVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAATYPQLNALNIMCLHSPDSAILSAVIFNALIIVFLIPLALKGVSYKPLTASAMLRRNLWIYGLGGLLVPFIGIKVIDLLLTVCSLV
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRI22_HUMAN
Sequence: MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQYYWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS
What is the function of this protein?
Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed:25683609, PubMed:35777501).  Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed:25683609, PubMed:35777501, PubMed:36042495).  Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed:25683609).  Acts also by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed:36042495).  Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed:26683615).  Plays also a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed:36159777).  Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed:35777501).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM22, 50 kDa-stimulated trans-acting factor, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, Staf-50, Tripartite motif-containing protein 22.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
Protein: RL3_SYNS3
Sequence: MSIGILGKKLGMSQFFDEQGKAVPVTLIEAGPCRITQLKSSETDGYQAVQIGFGEIREKLINKPAKGHLAKSGEDLVRHLCEYRVDDLDGIQLGGAVTVGDFAAGQKVDVSGDTMGRGFAGLQKRHGFSRGPMTHGSKNHRQPGSIGAGTTPGRIYPGKRMSGRYGGKKITTRGLTILKIDSERNLLVVKGSVPGKPGSLLNIRPANRVGAKPAKGGK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: SIM27_MOUSE
Sequence: MRPMSRRSLDWTYSLLLLAIVLLSWGFVIYASTVAARRQLQKEFPDKFF
What are the official names of this protein?
Small integral membrane protein 27, TOPORS antisense RNA 1.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y1337_SODGM
Sequence: MFCVIYRSSKQDQTYLFVERREDFYRVPADLMAHFGKPLFSMILPLDGSKKLASADTGKVKELFKEQGFYLQVPPPVESLLAQHQRAEKNLIIDPCILASE
What are the official names of this protein?
YcgL domain-containing protein SG1337.
Protein: YCF92_NEOYE
Sequence: MATFELIPYRLYLSQSNTWIHRIKAEIKIYIVALLWISIFIFSYFKLCIIALSLIAISFTIRSKQNIIQKHLLQTLLMTFLTTVLSFSVAISYKQYAEQEQSQYLSDSKKYKNSSSYYYIQIANDQRIKRQYLITTLKPSLYFFITIYSIKLVMITTSPEVLVITIYRSRIINKIFKNELLFIFLLSSHIVTSIINRIDKVIQVTSLRGSLNLYNSLTRPLMFSLLIFQVFFLEIIRESKEIAQALYTRNLNQENNNFLKIYTVKSNFSDRLNIIISTLYFIILALA
What are the official names of this protein?
Uncharacterized protein ycf92.
What is the protein family that this protein belongs to?
Belongs to the ycf92 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: DCTA_PARP8
Sequence: MKKPIYKVLYVQVIVAIIIGIALGHFYPALATDMKPLGDAFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALLYFEIVSTFALILGLAATHLLRPGVGFNVDPATLNGKEVASYAAKAHGQTTVDFLMHIIPDTLVSAFSQGEILQILLIALLFGAVLAHVGERGKPVTNFIESLSSILFGMVGIITKLAPIGAFGAMAFTIGKYGIGSLLPMLKLIGTFYLTSIVFVVVVLGFIAKMVGFNILRFVAYIKEEMLIVLGTSSSEAALPQLMLKLEKLGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQATNTDLTWGQQLTLLAVTMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSAWEKELDRSKLRAALSRDVSVTESAEV
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y132_MYCPN
Sequence: MGLQLSGLDASDSDQRELIWAKRPWAAFRGSWVNRLGRVESVWDLKGVWADQAHSAVSESQAATSSTTTTATGDTLPEHPNALAYQISSTDKDSYKASTQGSGQTNSQNTSPYLHLIKPKKVTASDKLDDDLKNLLDPNEVRVKLRQSFGTDHSTQPQPQPLKTTTPVFGTNSGNLGSVLSGGGTTQDSSTTNQLSPVQRVSGWLVGQLPSTSDGNTSSTNNLAPNTNTGNEVVGVGDLSKRASIESSRLWIALKP
What are the official names of this protein?
Putative adhesin P1-like protein MPN_132.
What is the protein family that this protein belongs to?
Belongs to the adhesin P1 family.
Protein: ABAMS_PEA
Sequence: MWKLKIGDGGKDRNIFSTNNFVGRQTWEFDPDAGTSQEKAQVEAARQHFYDNRFEVKACSDLLWRFQILKEKNFKQTIESVKIKDEEEISEENVAITLRRAVHHLSTLQSNDGHWPALNAGPLFYFPPLVFCMYVTGHLDSIFPYEYRKEILRYIYCHQNEDGGWGLHVEGHSIMFCTVLNYICMRILGEGPNGGKEDACARARKWIHDHGSVTHVSSWGKIWLSVLGIFDWCASNPMPPEFWMLPSFLLKHPAKMLCYCRLVYMPMSYLYGKRFVGPITPLILMLREELLTQPYEKVNWKKTRHLCAKEDLYYPHPLIQDLIWDSLYIFVEPLLTHWPFNKLLREKALQTVMKHIHYEDENSRYITIGCVEKVLCILACWVEDPNGDAFKKHLARLPDYLWVSEDGMTLHSFGSQTWDASLIIQALLATNLIEDVGPILTKAHEFIKKSQVRDNPSGDFKSMYRHISKGSWTFSDKDHGWQVSDCTAESLKCCLLLSMLPPEIVGEKMEPEMLYDSVNILLSLQGKKGGLPAWEPSEAVEWLELFNPIEFLEEIVVEREYVECTSSAIQALVLFKKLYPEHRKKEVENFIANAVRFLEYKQTSDGSWYGNWGICFTYGSWFALNGLVAAGKTYDNCAAIRKGVEFLLTTQREDGGWGESHLSSSKKIYVPLERSQSNIVQTSWAIMGLIHAGQMERDPTPLHRAVKLIINFQQEEGDWPQQELTGVFMKNCMLQYAMYRDIFPTWALAEYRRRILLASPAVAI
What is the function of this protein?
Multifunctional oxidosqualene cyclase producing alpha- and beta-amyrin and several other minor triterpenes.
What are the official names of this protein?
Mixed-amyrin synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: HTPG_CLOB6
Sequence: METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDDYYIRVVSDKENRILKIADTGIGMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGVGFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPCEKEAYGTEIILKIKDNTEEENYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWRKNKNELKSEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEKGLELYSSGVLIMNKCGDLLPDYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTKIKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKDILQDLLMFYSSKEKKMVTLAEYVSRMPEEQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMNYKEKEFKSVSSGDLGIEGEEKENTSNSDDKKNKELFESMKDILSGKVKDVRASKRLKNHPVCLANEGELSIEMEKVLNAMPNNQNIKADKVLEININHDVFKSLKEAYEGDKEKLKLYTDLLYNQALLIEGLAINDPVEFTNNICKIMK
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1445_STAAC
Sequence: MALKHYKNSDSTVFNDAKALFDLNKNILLKGPTGSGKTKLAETLSEVVDTPMHQVNCSVDLDTESLLGFKTIKTNAEGQQEIVFVDGPVIKAMKEGHILYIDEINMAKPETLPVLNGVLDYRRQITNPYTGEVIKAVPGFNVIAAINEGYVGTLPMNEALKNRFVVIHVDYIDGDILKNVIKEQSLLQDDKQIEQIIKFNEDLRTMSKQGQISEEAASIRALLDLCDLITVMPVERAIKRTIIDKLEDEREQQAIYNAVELNF
What are the official names of this protein?
Uncharacterized protein SACOL1445.
What is the protein family that this protein belongs to?
Belongs to the CbbQ/NirQ/NorQ/GpvN family.
Protein: IHFB_SALPB
Sequence: MTKSELIERLATQQSHIPAKAVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: TPIS_PSEMY
Sequence: MRRPLVAGNWKMHGTRASVAELIEGLRRQELPVEVDVAVFPSSLHVTQVVEGLAGKAVKVGAQDCAAQVEQGALTGELAVSQLVDGGCELVLVGHSERRLILGESDEVVVSKFAAVQKAGLTPVLCVGETREQREANATLGVVGGQLAAVIDALGVQALNNAVVAYEPVWAIGTGLTATPEQAQEVHAAIRAQVAQLDAQVASELRILYGGSVKAASAAELFGMQDIDGGLVGGASLNADEFGAICRAAGN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.