PharMolix/UniProtQA huggingface dataset:
Protein: ACP_CUPMC
Sequence: MDNIEQRVKKIVAEQLGVAEADIKNESSFVNDLGADSLDTVELVMALEDEFGMEIPDEEAEKITTVQQAIDYATAHVKA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEA4_KLULA
Sequence: MSFVLILSLVFGGCCSNVISFEHMVQGSNINLGNIVTFTQFVSVTLIQLPNALDFSHFPFRLRPRHIPLKIHMLAVFLFFTSSVANNSVFKFDISVPIHIIIRCSGTTLTMIIGWAVCNKRYSKLQVQSAIIMTLGAIVASLYRDKEFSMDSLKLNTDSVGMTQKSMFGIFVVLVATALMSLLSLLNEWTYNKCGKHWKETLFYSHFLALPLFMLGYTRLRDEFRDLLISSDSMDIPIVKLPIATKLFMLIANNVTQFICIKGVNMLASNTDALTLSVVLLVRKFVSLLLSVYIYKNVLSVTAYLGTITVFLGAGLYSYGSVKTALPR
What is the function of this protein?
Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into Golgi vesicles where glycosyltransferases function.
What are the official names of this protein?
UDP-N-acetylglucosamine transporter YEA4, Golgi UDP-GlcNAc transporter.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: REXO3_CANAL
Sequence: MNNNAQNKRSLDDSNGNDTKRPKQEDPKYILPKQVNTYPATLPERKKNIEYILNILTKKQPNITNPKLKAIDIEYEIAKKSTNATYKTVFRQEVFKLTKPTKSPSQLSPQQEHLKKLDQEAKELKILKEMVVSRKTLIAFGYIMEPPESIPNEKITRICNRCGTEFRLDQQLQPIVCEFHHGKKQRGKYICCMSNVDGQPCSKAKNHVYLLNTPEEKQALLPYQFTKELFTTTSTKSKSRVLGIDCEMGFTTKGFELMRITAIDYFTSKTVLDIFIKPIGEIVDFNTRYSGIHELTDDFLSWEQSMEKLGEIMDSETILIGHGLENDMNAMRLIHENIIDTSILFPNKWKTGPTRRWSLKDLAFEFLSRRIQTGEHDSCEDSIAAIDIVKYFVKKRLQSIGSSS
What is the function of this protein?
3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.
What are the official names of this protein?
RNA exonuclease 3.
What is the protein family that this protein belongs to?
Belongs to the REXO1/REXO3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PPSA_ASPOR
Sequence: MNSNTPTDIVSFCFETQADHNATGPILIDGLTPTRSLTLHQFRQLVCQLIAGLHEQKIQQGQCILVHLENSILYPALFLAIVGVGAVYMGAHPASSATELEHLLSLANPSLIITGRDTLSTVLQCTMSPSGGKKEKIPSDRVWVLNDIDQVLCEAFSSTPDASMGDAAYHHRRDITKLLHSGQRPWRTFDDDGQKSKITPAAMFATSGTSGLPKAAILSHHALIQQHISIHHPVPYPVTRLLTLPLFHRYGALVALFFPTRYAQPLILLPGFQLRPFLSAIHVHGVTETYLSPAMVHILIQSTPQSSSIRESLRSLRYVCVGGAPIDSRPLQSLQDMLHPEACVAQAWGMTETATVFQDRYCLPSRQFDKGSVGVVLPGYQVRLVDVSGSGRVLDNATEIPGELQVRGSGLFTSYKGHPDHTDGDGWFSTGDVMYQKNGHYFLVGRMKEMIKVRGYQVSPVELEAELAQHPLVKDAAVIGVLATDGSSELPRAYVVPLSWAERPSPEDIYDFMRQRLAGYKFLEGGVVFVDSIPRNSGGKIRRTKLSELDDQRDKLIALLT
What is the function of this protein?
Acyl-CoA ligase; part of the gene cluster that mediates the biosynthesis of 2,4'-dihydroxy-3'-methoxypropiophenone (PubMed:32885554).  The first step of the pathway is the conversion of acetate into acetyl-CoA by the acyl-CoA ligase ppsA (PubMed:32885554).  Acetyl-CoA is then used as a starter unit by the polyketide synthase ppsB and condensed with 4 malonyl-CoA unit to produce the pentaketide backbone (PubMed:32885554).  During polyketide extension, the polykedite chain is probably reduced and dehydrated by the KR and PT domains, respectively (Probable).  O-methylation seems to be catalyzed by an unknown methyltransferase rather than by the CMeT domain of ppsB (Probable).  Two hydroxylations and one further decarboxylation step catalyzed by yet unknown enzymes are then required to yield 4'-hydroxy-3'-methoxypropiophenone (Probable).  PpsC functions as a carrier protein to transport 4'-hydroxy-3'-methoxypropiophenone to a specific cell compartment in which 4'-hydroxy-3'-methoxypropiophenone is hydroxylated to 2,4'-dihydroxy-3'-methoxypropiophenone by a still to be identified enzyme (PubMed:32885554).
What are the official names of this protein?
Acyl-CoA ligase ppsA, 2,4'-dihydroxy-3'-methoxypropiophenone biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YBEY_NOSS1
Sequence: MLSEESGYLVQVELDVQDCFFESFPEAAQASGYMDSQVSPATWQDWFHRWLEILDSSLPPAPSYEIGLRLTDDTEIQAINAQYRQQNKPTDVLAFAALEVDLPQNPEMVAEPLYLGDIVVSINTAQRQAGQQEHSLSTELAWLTAHGLLHLLGWDHPDEESLIAMLQQQVVLLEAIGININVNY
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_CALS8
Sequence: MRSDIVKKGFEKAPQRSLFKAMGYTDEEIRRPLIAVVNSWNEVVPGHIHLDKIAEAVKAGIRLAGATPMEFNVIGVCDGIAMGHIGMKYSLITRELIADSIEAMVMAHQFDGMVLIPNCDKIVPGMLMAAARVNIPSILISGGPMLAGRVDNKVCDLNSVFEAVGAYSAGKITDEELFALEENACPGCGSCSGMFTANTMNCLSEVLGMALPGNGTIPAVMAARIRLAKMAGMKIVELVERDIKPSDILTIEAFENALTVDMALGGSTNTILHLPAIANELGIKLNLDIINDISDKTPNLCKLSPAGHYHIEDLYFAGGVQAVMNELSKKGLIHLDLLTVTGKSVGENIKDAKVKDYNVIRPIDNPYSETGGLVIVRGNLAPDGAVVKKSAVPPKLMRHRGPARVFESGEEVFEAILKGKIQKGDVIVIRYEGPKGGPGMREMLSPTSALAGVGLIEDVALITDGRFSGATRGACFGHVSPEAAERGPIAAVQDGDIISIDIENKTLTLEVPEEEIKRRLESLGPFEPKVKKGYLYRYSKLVRSASTGAILE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: COX5B_THUOB
Sequence: GTLKGIPTDDEQATGLERRT
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5B, mitochondrial, Cytochrome c oxidase polypeptide Vb.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5B family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ENV_FIVT2
Sequence: MAEGGFTHNQQWIGPEEAEELLDFDIAVQMNEEGPLNPGVNPFRVPGITSQEKDDYCKILQTKLQELKNEVKEVKIEEGNAGKFRRARYLRYSDENVLSIVYLLIGYLRYLIDHRSLGSLRHDIDIETPQEEHYNNSEKGTTLNIKYGRRCCISTFIMYLILFAGVGIWLGARAQVVWRLPPLVVPVDDTEIIFWDCWAPEEPACQDFLGTMIYLKANVNISIQEGPTLGNWAREIWSTLFKKATRQCRRGRIWRRWNETITGPLGCANNTCYNISVVVPDYQCYVDRVDTWLQGKVNISLCLTGGKMLYNKETRQLSYCTDPLQIPLINYTFGPNQTCMWNTSLIKDSEIPKCGWWNQVAYYDTCKWEEANVTFQCHRTQSQSGSWIRTISSWKQRNRWEWRPDFESEKVKISLQCNSTKNLTFAMRSSSDYYDVQGAWIEFGCHRNKSKRHSEARFRIRCKWNEGNNISLIDTCGTNPNVTGANPVDCTMKANTMYNCSLQDSFTMKIEDLIVHFNMTKAVELYNIAGNWSCTSDLPKGWGYMNCNCTNGTDNSETKMACPKNQGILRNWYNPVAGLRQALIKYQVVKQPEYLIVPEEVMQYKFKQKRAAIHIMLALATVLSMAGAGTGATAIGMVTQYHQVLATHQQALEKITEALKINNLRLITLEHQVLVIGLRVEAIEKFLYTAFAMQELGCNQNQFFCKIPPSLWSMYNMTLNQTIWNHGNISLGNWYNQTRDLQNKFYEIIMDIEQNNVQGKTGIQQLQKWENWVGWIGKIPQYLKGLLGSVLGIGLGILLLLICLPTLVDCIRNCTNKILGYTVIAMPEIDDEEVHLSVELRRNGRQCGISEKEEE
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp150, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: QUEC_RHOPT
Sequence: MTDHSSDKTALVLFSGGQDSATCLAWALARFARVETIGFDYGQRHLIELECRARLLDGFRAISDDWAAKLGDNHTLTIPTLAEISDTALTRDVAIAMGADGLPNTFVPGRNLIFLNFAAALAYRRGITDIVGGMCETDYSGYPDCRNDTIQALQTALSLGMARDITLHTPLMWRDKAATWQLAQDLGGDALVDLIREDSHTCYLGERGARHDWGYGCGECPACRLRSKGWIEYASGI
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: ALG12_MOUSE
Sequence: MAGKKSSGKRSWPLLGLLVTVATIHLVICPYTKVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLGPLVIAAFSSPVVYVLSLLEVSKFYSQLIVRGVLGLGVISGLWTLQKEVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWLQRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAVDRRTYALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAARGCTYILNKKSWPYKVRAMLVTGHILVNVAYTATSLYVSHFNYPGGVAMQQLHELVPPQTDVLLHIDVAAAQTGVSRFLQVNDDWRYDKSEDVGAAAMLNYTHILMEAVPGHPALYRDTHRVLASIEGTTGISLNLMKLPPFDVNLQTKLVLLERLLRPA
What is the function of this protein?
Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
What are the official names of this protein?
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase, Asparagine-linked glycosylation protein 12 homolog, Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase, Mannosyltransferase ALG12 homolog.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MRE11_COPC7
Sequence: MSDYEEDTRPPPNIETADPEDTIKILLATDNHIGYLERDPIRGQDSINTFREILQLAVKNEVDFILLAGDLFHENKPSRDCLYQTLALLREYTLGDKPIQVELLSDPDEGKAAGFSFPAINYEDPNFNISIPVFSIHGNHDDPQGPGVNGALCALDVLSVSGLLNYMGKFDLPTSDADAATTGIAVRPVLLRKGSTKLGMYGVGNVKDQRMHFELRSNRVRMYMPKDKDEWFNILLVHQNRVKHGPQEYVPEGMFDDSVDLVVWGHEHDCRIIPEPVAGKNYYITQPGSSVATSLADGEAIEKHVALLEIKGKEFQLTPIPLRTVRPFVISEVVLEDAAEEEGLDVNDQMEITKYLKQKVNDLIDQAQALWEERNARSIEAGDEEIPPMLPLVRLKVDTTNVTQTSNPIRFGQEFQGRVANPRDLLVFHRSKKAGKRGAGKVDIDQPELSIDDPDLTVSEKLAKVRVKTLVREYLAAQELQLLGENGMSDAIQMFVEKDDIHAIQTHVNKSLKTMLKNIKSDEVDEDDLDDLLAKAKQRQEEEYLEATRAGESAKGKGKAKATDDDGGAASDDSMLMDIDTGGGATFNMSDDDDDDEPPPPPKRRAATSRATTTKKAPAKAPAKKATTTTARGRGKKAAPPSSDDEVIELDDDEDEISEEEVVAKPVKRTSRAAVLSQSQAPAKKAPAKKKTPARQTQTQLSFAPAGRSSRAAASKARSKMVFDDDDDDDD
What is the function of this protein?
Involved in DNA double-strand break repair (DSBR).  Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity.  Also involved in meiotic DSB processing (By similarity).
What are the official names of this protein?
Double-strand break repair protein MRE11.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PB2_INBAD
Sequence: MTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIERNPSLRMKWAMCSNFPLALTKGDMANRIPLEYKGIRLKTNAEDIGTKGQMCSIAAVTWWNTYGPIGDTEGFEKVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLNPLTKEMPPDEASNVIMEILFPKEAGIPRESTWMHRELIKEKREKLKGTMITPIVLAYMLERELVARRRFLPVAGATSAEFIEMLHCLQGENWRQIYHPGGNKLTESRSQSMIVACRKIVRRSIVASNPLELAVEIANKTVIDTEPLKSCLAAIDGGDVACDIIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGNGTIQKIGIWDGEEEFHVRCGECRGILKKSKMRMEKLLINSAKKEDMKDLIILCMVFSQDTRMFQGVRGEINFLNRAGQLLSPMYQLQRYFLNRSNDLFDQWGYEEPPKASELHGINELMNASDYTLKGVVVTKNVIDDFSSTETEKVSITKNLSLIKRTGEVIMGANDVSELESQAQLMITYDTPKMWEMGTTKELVQNTYQWVLKNLVTLKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRDQEVMKTDQFIKLLPFCFSPPKLRSNGEPYQFLRLMLKGGGENFIEVRKGSPLFSYNPQTEVLTICGRMMSLKGKIEDEERNRSMGNAVLAGFLVSGKYDPDLGDFKTIEELEKLKPGEKANILLYQGKPVKVVKRKRYSALSNDISQGIKRQRMTVESMGWALS
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ICK12_TRILK
Sequence: MKSIVYMLLFCTFTVVILGHPNDHGALIPYRAEKLPNGEWCIRPGYSCSERGQCCMPVDGDTYTYGCGRAWSEGSKVCFICNRESSMC
What is the function of this protein?
Probable neurotoxin with ion channel impairing activity.
What are the official names of this protein?
Toxin ICK-12.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 27 (Jztx-72) family. ICK-41 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NDUB1_BOVIN
Sequence: MNLLQVVRDHWVHVLVPMGFVFGYYLDRKNDEKLTAFRNKSLLYKRELKPNEEVTWK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, Complex I-MNLL, CI-MNLL, NADH-ubiquinone oxidoreductase MNLL subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFB1 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: HFQ_STUS1
Sequence: MSKGHSLQDPYLNTLRKERVPVSIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPGRPVRLPTAGDAEQSESGND
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: GRM2A_HUMAN
Sequence: MTALSRSEATEEGGNQQMHRKTASLNSPVSCKEKPDRVEEPPDYSLHWPEGLKGEEIKKCGREGITLNKYNQQYHKLFKDVPLEEVVLKVCSCALQRDFLLQGRLYISPNWLCFHASLFGKDIKVVIPVVSVQMIKKHKMARLLPNGLAITTNTSQKYIFVSLLSRDSVYDLLRRVCTHLQPSSKKSLSVREFSGEPESLEVLIPEMKWRKVCPSSRSLSLPDNIPCIPPSSVDSTDSFFPSRKPPMSEKSRAQVASENGGRWAWPMPGWGPACPKKMPNCSPTAKNAVYEEDELEEEPRSTGELRLWDYRLLKVFFVLICFLVMSSSYLAFRISRLEQQLCSLSWDDPVPGHR
What is the function of this protein?
Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis.  Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner.  Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).
What are the official names of this protein?
GRAM domain-containing protein 2A.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Peripheral membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Anchored at the ER, PM binding is mediated via GRAM domain and phosphatidylinositol lipid interaction. Localizes to distinct EPCS than GRAMD1A.
Protein: TSN36_DANRE
Sequence: MDCGIITSKTILLLLSLIFWAAGAALAYVGSYVIKSYNNFEDFMSDRHTLIPAAIIIGVAVVMFIIGFVGCCATLRESKVGLGLFLIIIMLIFAAEVTAFVFGIIYRGRIRGDLEKSMNDVFLKYDGLNSETHAVDYLQSQLECCGVKNQTDWTLTSWFAQHNNTVPQSCCKANMTQCTGQLSQPDLLNTQGCEAKLEQVLQDVLSYAMLVILGFAIIKFFGMLSVCVITCKSKKNEYQPLYA
What is the function of this protein?
Plays a role in migration and segregation of pigment cells (melanophores and xanthophores).  Contributes to pigment stripe patterning in the epidermis.
What are the official names of this protein?
Tetraspanin-36, Tetraspanin-3c.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Mainly found in the Golgi apparatus.
Protein: RFA3_HUMAN
Sequence: MVDMMDLPRSRINAGMLAQFIDKPVCFVGRLEKIHPTGKMFILSDGEGKNGTIELMEPLDEEISGIVEVVGRVTAKATILCTSYVQFKEDSHPFDLGLYNEAVKIIHDFPQFYPLGIVQHD
What is the function of this protein?
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress.  It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism.  Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682).  In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation.  Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808).  It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage.  Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716).  Also plays a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279).  Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage.  May also play a role in telomere maintenance.  RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961).  As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair.  Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase.  The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).
What are the official names of this protein?
Replication protein A 14 kDa subunit, RP-A p14, Replication factor A protein 3, RF-A protein 3.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RT12_PONAB
Sequence: MSWSGPLRGLNTSLTCGPALVPRLWATCSMATLNQMHRLGGPPKRPPQKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKCCRVRLSTGQEAVCFIPGEGHTLQEHQIVLVEGGRTQDLPGVKLTVVRGKYDCGHVQKK
What are the official names of this protein?
28S ribosomal protein S12, mitochondrial, MRP-S12, S12mt, MT-RPS12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TRUD_ECOK1
Sequence: MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEQAAVAEETELQTLLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIHFWLPAGSFATSVVRELINTTGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: TMCA_HAEIN
Sequence: MPSRQLQILIRKTLPLVPDHVLIIGESGIAFSKATNLLGQEFEHILFDGRNGIHLEALAIAAGTLKMGGTLCLVLSDWENLSQQPDQDSLRWNGNQSAIATPNFIYHFKQCIERYHFPILREESAVEFPTVFYSNEHHKNATLAQQQIIENILQAEQDIYFLTAKRGRGKSALLGMLANQIQAPVYLTAPNKSAVHSVIEFSEGDIEFIAPDELALTLQTEPEFSQSAWLLVDEAAMIPLPLLQEYSRYFQHIVFSTTIHSYEGTGRGFELKFKRKIHRTFQHFELKQPLRWQENDPLEHFIDDLLLLNAEDDFQHFDYSNITYNIEENAKNLSFPCLRGKVPEGPKGDLDIASLPQALEALLTSKGSEGKYNRQFFFRDFYGLMTIAHYRTSPLDLRRLLDGKNQRFYFAEYQQNLLGAIWALEEGNMADDELIIQIQQGKRRPKGNLVPQALCFHENLSQACKLRSLRISRIAVQPNWQQKGIGQNLMQAMENADVDFLSVSFGYTDELAKFWQKCGFVLVHLGEHQEASSGCYSAIALKGISKEGLALVDTAYKQFQRNLPLSFHPFAINFEQNQLDWQLDDFDWMSLKNFANFHRTLFSSIPAMRRLLKLAGKENFPLISAYLTKKQFPINKKKGVECLRLEIKQYLERGTL
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
What are the official names of this protein?
tRNA(Met) cytidine acetyltransferase TmcA.
What is the protein family that this protein belongs to?
Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.