PharMolix/UniProtQA huggingface dataset:
Protein: EGLX_EMENI
Sequence: MSSSLMRRVGSLAASAIIFPGIAHAASNYKLKESWEGEKILNHFHFFDNADPTNGFVTYVNQSYAESAGLVKTTDSGSLYLGVDYENVLTVDGPGRESVRIESNEYYDQGLYVVDIQHMPGSICGTWPAFWTVGPDWPTDGEIDIIEGVNKHDANKIVLHTSDTCDVGGGYKMTGDMTSSECGEASGTIGCVVQGKQGSSGDPFNEQGGGVYAMEWQEKYLKIWYFPRSSIPESLTAGTPDVSSFGTPMAHLQGSCNFKERFTHQKLILDTTFCGDWAGGVFGDSGCPVSDPSDPMLSCKNYVAENPAVYKNAYWELNSIKIYQLGGTAEVEGTQSAAAESTAAEATAAETTAAATQTANGGSIEEITTSTHSVTRTKTVSATHSTETAAVTETAAATTAAASVASEVDATNTQPVSKTKSTSYVTSTTTLCPVESSQAAATESVSRTKTTSYVTITTTLCPVESLQTANAVPSAKASTDAAAATTPAAEPHPSNAETPADSKSSADAVTAQATKTTIAVNTPNPATDSASSVPPDSIVYTAPEVTSSSSVPLFTIVSSSSQFVTVPTAAPSSFEPTDAVRDGADSYSTAASPTTPSNPVFTGVGSKVSISASVAIAAFVMLLLVN
What is the function of this protein?
Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.  Active on laminarin.  lichenan, soluble carboxymethyl cellulose but not on pustulan.
What are the official names of this protein?
Endo-1,3(4)-beta-glucanase xgeA, Mixed-linked glucanase xgeA.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: SYS_SALEP
Sequence: MLDPNLLRNEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVNTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDTLLAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEIRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNHDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEVPLTNLVRDEIIDEDQLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARAB_ECOL6
Sequence: MAIAIGLDFGSDSVRALAVDCATGEEIATSVEWYPRWQNGQFCDAPNNQFRHHPRDYIESMEAALKTVLAELSVEQRAAVVGIGVDTTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEAEEITRLCHAPGNVDYSRYIGGIYSSEWFWAKILHITRQDNAVAQSAASWIELCDWVPALLSGTTRPQDIRRGRCSAGHKSLWHESWGGLPPASFFDELDPILNRHLPSPLFTETWTADIPVGTLCPEWAQRLGLPESVVISGGAFDCHMGAVGAGAQPNALVKVIGTSTCDILIADKQSVGERAVKGICGQVDGSVVPGFIGLEAGQSAFGDIYAWFGRVLGWPLEQLAAQHPELKEQINASQKQLLPALTEAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPLLFGGLIAATAFGARAIMECFTAQGIAVNNVMALGGIARKNQVIMQACCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPSAQQKMASAVEKTLQPRNEQAQRFEQLYRRYQQWAMSAEQHYLPTSAPAQADQAVPTL
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: HLDD_RALSO
Sequence: MTIIVTGAAGFIGANLVKGLNDRGETDIIAVDNLTRADKFRNLVDCEISDYLDKTEFVERFARGDFGKVRAIFHEGACSDTMETDGRYMMENNYRYTLALMKACLDQGVQFLYASSAATYGASDTFREDREFEKPLNVYGYSKFLFDQIVRRTLPGALSQIVGFRYFNVYGPREQHKGRMASVAFHNFNQFRTEGTVKLFGEYNGYPQGGQMRDFVSVEDVVKVNLFFFDHPDKSGIFNLGTGRAQPFNDIATTVVNTLREAEGKPALSTEELAQEGLVEYVKFPDALRGKYQCFTQADQGKLRAAGYSAPFLTVQEGVARYCRWLMAQPA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: PIG3_CLAP2
Sequence: MPAPAEVQQATLSKFVDAWKRWNADDFIGLWSDSFTFKVLPLSDGKPTRPRDKVAPLYRNLIGTLTDYKLDVKHIVHDASKGKACIYAVASANAPCGDYKNEQAIFITFSESGDKIESMEEMNDNAFRKEWDPKYHAYHGYGQPPTAKAAAGS
What is the function of this protein?
Part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia (PubMed:28955461).  The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones endocrocin and clavorubin (PubMed:28955461).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) CPUR_05437 (By similarity).  The atrochrysone carboxyl ACP thioesterase CPUR_05436 then breaks the thioester bond and releases the atrochrysone carboxylic acid from CPUR_05437 (By similarity).  The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (By similarity).  The next step is performed by the anthrone oxygenase CPUR_05434 that catalyzes the oxidation of emodinanthrone to emodin (By similarity).  Emodin is further modified to yield monodictyphenone via several steps involving CPUR_05427, CPUR_05428, CPUR_05429 and CPUR_05430 (By similarity).  The short chain dehydrogenase/reductase CPUR_05418 then catalyzes the C-5 ketoreduction to give the xanthone skeleton of the monomeric units (PubMed:32105084).  Ergochromes formation requires further dimerization steps of different xanthone units, probably catalyzed by the cytochrome P450 monooxygenase CPUR_05419 (PubMed:28955461).  CPUR_05425, CPUR_05426 and CPUR_05431 are unique to Claviceps, thus it is likely that they are involved in further modification of xanthone units or in their dimerization (PubMed:28955461).  The yellow ergochromes and the red anthraquinone pigments endocrocin and clavorubin are products from the same PKS derived precursors and the latter are likely shunt products in the pathway of xanthone biosynthesis (PubMed:28955461).  It is proposed that atrochrysone carboxylic acid released from the PKS CPUR_05437 can also be converted to endocrocin anthrone which is further oxidized into endocrocin by CPUR_05435 (By similarity).  Endocrocin could be then modified to clavorubin, possibly by CPUR_05423 and CPUR_05431 (PubMed:28955461).  Clavorubin is the principal anthraquinone metabolite produced by the cluster with a much higher yield compared to endocrocin (PubMed:28955461).
What are the official names of this protein?
Ergochrome gene cluster protein CPUR_05425.
Protein: NU4M_ARTSF
Sequence: MLMYKLMSEFHLEWGITLLTLNFSYFLFNSYQIKANWPLSYSTILVSLFVLLWLTFTTQSFILFYVFFECSLIPTIILILGWGYQPERLPASYYFLFYTLLSSLPLLFIIIAHTSIYSSSFLQFWGNFMDKMIFLLAILSFLVKLPVYFAHIWLPKAHVEAPVTGSMVLAAILLKLGGYGLYLVQVLNIYSETTLMGVCLMGGIFSCLICLRQSDVKSLIAYSSVAHMSFVILGMLMSCTYTNMSSILMMVSHGICSSGLFYLSYLFYARIWSRSFLLTRSMISLFPYLCFWWLSLSFLNMGLPPSLNFFSEMYFFIGAFSLDWMVVGLSGILCFLSSCYCIYLYSSTSHGESLYIFKLISMQLKGMYNRKSSSDSVTDFNFRLLL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: CADH7_ARATH
Sequence: MGKVLEKEAFGLAAKDESGILSPFSFSRRATGEKDVRFKVLFCGICHTDLSMAKNEWGLTTYPLVPGHEIVGVVTEVGAKVKKFNAGDKVGVGYMAGSCRSCDSCNDGDENYCPKMILTSGAKNFDDTMTHGGYSDHMVCAEDFIIRIPDNLPLDGAAPLLCAGVTVYSPMKYHGLDKPGMHIGVVGLGGLGHVAVKFAKAMGTKVTVISTSERKRDEAVTRLGADAFLVSRDPKQMKDAMGTMDGIIDTVSATHPLLPLLGLLKNKGKLVMVGAPAEPLELPVFPLIFGRKMVVGSMVGGIKETQEMVDLAGKHNITADIELISADYVNTAMERLAKADVKYRFVIDVANTMKPTP
What is the function of this protein?
Involved in lignin biosynthesis.  Catalyzes the final step specific for the production of lignin monomers.  Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
What are the official names of this protein?
Cinnamyl alcohol dehydrogenase 7, AtCAD7, Cinnamyl alcohol dehydrogenase-like protein B.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: HIS3_MYCBO
Sequence: MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAMAT_AMARI
Sequence: MSDINATRLPIWGIGCDPCVGDDVAALTTRGEA
What is the function of this protein?
Toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:24613547).
What are the official names of this protein?
Beta-amanitin proprotein.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: KTHY_ENTFA
Sequence: MQGIFITFEGPDGAGKTSVLKEVSERLAKESKRKIVTTREPGGIPIAEKIRTVILDPRNDRMDERTEALLYAAARRQHLVEKILPALEAGHLVLCDRFVDSSLAYQGAGRRIGIAPIASINAFATEGVSPDFTIYLDVDSDTGLRRIQENRTQQIDRLDSEGLEFHQRVRHEYLKLAEENPQRIKKIDARMSLELVVEATYQAIIERYPENF
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SSRP_CLOBM
Sequence: MSKKKGSNTLAENRKARHDYFIEETYEAGIELVGTEVKSIRQGKANLKDSYAEIRNGEVFVRNMHISPYEQGNIYNKDPLRDRKLLLHKSEIYKLVGFTTQQGYTLIPLSLYLKHGRVKVSLAVAKGKKNYDKRDAMLEKAAKREMDRQIKERSRY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: GABD1_MYCBO
Sequence: MPIATINPATGETVKTFTAATDDEVDAAIARAHRRFADYRQTSFAQRARWANATADLLEAEADQAAAMMTLEMGKTLAAAKAEALKCAKGFRYYAENAEALLADEPADAAKVGASAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIARGGFPDGCFQTLLVSSGAVEAILRDPRVAAATLTGSEPAGQSVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVSTAVTGRVQNNGQSCIAAKRFIVHADIYDDFVDKFVARMAALRVGDPTDPDTDVGPLATEQGRNEVAKQVEDAAAAGAVIRCGGKRLDRPGWFYPPTVITDISKDMALYTEEVFGPVASVFRAANIDEAVEIANATTFGLGSNAWTRDETEQRRFIDDIVAGQVFINGMTVSYPELPFGGVKRSGYGRELSAHGIREFCNIKTVWIA
What is the function of this protein?
Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate.  It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium (By similarity).
What are the official names of this protein?
Succinate-semialdehyde dehydrogenase [NADP(+)] 1, SSADH 1, SSDH 1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: U77B2_CROXC
Sequence: MDSASRQHVALIAFPFASHPGNLFAFARALAAAAPDITFSFLTTTFAAATLPPAPPAANLRLCHVADGVPEGGLPPGTTIHGRIGMFLRATPGNFRDGVRAAEEEVGVKVSCVVSDAFLWMTADVAEEIGAQWLPLWTCAPAALLAHVSTDQLRERFGVEKQATAGWADELVDFIPGLSCLRIRDIPDEIVTNWHSDLSILLHRMGNQLTSATAVALNTFDGLDTTIDAALASLFKKTLPIGPLNLLSSPPPLQPGDEKCLSWLDGQEDATVAYVSFGTMVLMPTQSDVSEIAQGLESSGVRFLWSLREEARAGLLPPGFLERTAGRGLVVPWAPQVRVLGHRAVGAFVTHCGWNAVMESVTSGVPMACLPSFADQKTNARMVSAAWGIGEALRGEKVTKEEVVRSMEIVMMGEEGRRMRERIGNLREKAAEAVGPGGSSSENFKSVLEMVRGTAN
What is the function of this protein?
Rhamnosyltransferase involved in montbretin A (MbA) biosynthesis (PubMed:29967287, PubMed:31004005).  Catalyzes the 3-O rhamnosylation of myricetin to produce myricetin 3-O-alpha-L-rhamnoside (MR), a precursor of MbA (PubMed:29967287, PubMed:31004005).  MbA is a potent inhibitor of human pancreatic alpha-amylase and is being developed as drug candidate to treat type-2 diabetes (PubMed:29967287, PubMed:31004005).  In vitro, is able to transfer UDP-glucose and UDP-xylose with 50-fold less efficiency compared with UDP-rhamnose (PubMed:29967287).  In vitro, can use kaempferol or quercetin as substrates, although these two flavonols may not be physiological substrates in vivo (PubMed:29967287).
What are the official names of this protein?
Myricetin 3-O-rhamnosyltransferase UGT77B2, UDP-glucosyltransferase 1, CcUGT1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: HEMH_BRUSU
Sequence: MSGTDKVRVNVSQTAQTPLHTSAKLPKVGVLLVNLGTPDGTSYGPMRRYLAEFLSDRRVIEWSRLIWYPILYGIVLNTRPRRSGRLYDRIWNHENNESPLRTYTRAQGEKLAKALSDQPNVVVDWAMRYGQPSIESITDRLLQQGCERIVIFPLYPQYSATTTATVNDKFFEALMKKRFMPAIRTVPSYEAEPVYIDALARSVEKHLATLSFKPEVILTSYHGIPKSYSDKGDPYRQQCLETTRLLRERLGLGEDEMRATFQSRFGPEEWLQPYTDETVKELAKNGVKSVAVLNPGFVADCLETVDEIGNEAAEEFLENGGENFSHIPCLNDSEEGMKVIETLVRRELLGWV
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_LACLS
Sequence: MKKVLVKAVHGYQRWISPVFPPACRYYPTCSNYMIQAIEKHGPAKGLAMGTARILRCHPFCQPGYDLVPKHFSLRRNWAEPEKKEEEDSK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VMA21_COCIM
Sequence: MATRRNPTKESITTSPPPDQQPRQPGELEHREAIQLRDLPGYPQQVLWKLIIYSIAVLVLPLSAYFYSVNYVFDGNTTYAGATAAITANLILFSYIVVAMREDKGDQEQLREQQQLRGNKEETKKMK
What is the function of this protein?
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
What are the official names of this protein?
Vacuolar ATPase assembly integral membrane protein VMA21.
What is the protein family that this protein belongs to?
Belongs to the VMA21 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Protein: TRHO_STRPF
Sequence: MSEKIRVLLYYKYVSIENAQEYAAKHLEFCKSIGLKGRILIADEGINGTVSGDYETTQKYMDWVHSDERFADLWFKIDEENQQAFRKMFVRYKKEIVHLGLEDNNFDSDINPLETTGEYLNPKQFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKDKFMEKRVVVYCTGGVRCEKFSGWMVREGFKDVGQLHGGIATYGKDPEVQGELWDGAMYVFDDRISVPINHVNPTVISKDYFDGTPCERYVNCANPFCNKQIFASEENETKYVRGCSPECRAHERNRYVQENGLSRQEWAERLEAIGESLPEFVGA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RAA5D_ARATH
Sequence: MSSDDEGGEEYLFKIVIIGDSAVGKSNLLSRYARNEFNAHSKATIGVEFQTQNMEIEGKEVKAQIWDTAGQERFRAVTSAYYRGAVGALVVYDISRRSTFESVGRWLDELKTHSDTTVARMLVGNKCDLESIRAVSVEEGKALAETEGLFFMETSALDSTNVKTAFEMVIRDIYTNISRKQLNSDTYKTELSMKNRVSLVKDDNKSSTQGFGFSCCSSS
What is the function of this protein?
Intracellular vesicle trafficking and protein transport.
What are the official names of this protein?
Ras-related protein RABA5d, AtRABA5d.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: ATG14_MAGO7
Sequence: MSCYICGRGHHAQRLPFLCPIDARNRLYEGRLAQAHTLIDSDRLKQQTNALIEQPPPTAAKASRSSPAARKAAIDDWASKHQEAIDRTAEIIAQADRLKAEVEAARQEIRQRKKTLARRKSDLAEAADGIEEKRKKQLDKVKDNIAATRADWDLVHESTASNRAFLCMEAARLYGLRRLKKGSSVKYELGGAEVVDLHALTGASPQAITISFSHIVHILNRACQYLAIRLPAEIILPHADYPRPAILSITSSYSYNHDDIPYPGTSDQQSELNTLPQDDLFYQRLPRARPLFIDRPLPVLAKEDPAMYSLFIEGVALLAHDVAWACCSQGVPVGPEDVLHVGRNLYNLLIGNQLLRGVSSNDGGNSTPQMGRYSHGAVHSYLGSAEGSDLVRTFRLPNPIKLADRLKSKLSSDAPNPDWELLEDDAWT
What is the function of this protein?
Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (PubMed:28067330).  This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (By similarity).  ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity).  Plays a crucial role in hyphal development, conidiogenesis and pathogenicity (PubMed:28067330).  Also required for glycogen mobilization, quantity of lipid bodies, and the turgor pressure of appressoria (PubMed:28067330).
What are the official names of this protein?
Autophagy-related protein 14.
What is the protein family that this protein belongs to?
Belongs to the ATG14 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Protein: TRPB_STRR6
Sequence: MAYQEPNKDGFYGKFGGRFVPETLMTAVLELEKAYRESQADPSFQEELNQLLRQYVGRETPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQVWLAKRMGKKKIIAETGAGQHGVATATAAALFNMECIIYMGEEDVKRQALNVFRMELLGAKVEAVTDGSRVLKDAVNAALRSWVANIDDTHYILGSTLGPHPFPEIVRDFQSVIGREAKQQYRDLTGQNLPDALVACVGGGSNAIGLFHPFVEDESVAMYGAEAAGLGVDTEHHAATLTKGRPGVLHGSLMDVLQDAHGQILEAFSISAGLDYPGIGPEHSHYHDIKRASYVPVTDEEALEGFQLLSRVEGIIPALESSHAIAFAVKLAKELGPEKSMIVCLSGRGDKDVVQVKDRLEADAAKKGEAHA
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: HIS1_MYCSS
Sequence: MLRVAVPNKGTLSEPAAEILSEAGYRRRTDTKDLTVVDPANNVEFFFLRPKDIAIYVGSGQLDLGITGRDLAAESDAPVRERLALGFGSSTFRYAAPAGRDWAPEDLAGRRIATAFPNLVRKDLAGRGIEATVIRLDGAVEISVALGVADAIADVVGSGRTLGLHNLVAFGDSLCDSEAVLIERDGAGDENAAARDQLAARVQGVVFGQQYLMLDYDCPRHVLDRATEVTPGLESPTIAPLADQDWVAVRALVPRRDVNSIMDELAAIGAKAILASDIRFCRF
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA1_RHIME
Sequence: MLSQTNDAFFTRSLADSDPEIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQYVDIAEALAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREDDHLLDMDEVARKAREQKPKLIIAGGTAYSRIWDWKRFREIADEVGAWLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPRGGMILTNDEEIAKKINSAVFPGLQGGPLMHVIAAKAVALGEALQPSFKDYAAQVVKNARTLAETLKANGLDIVSGGTDNHLMLVDLRKKNATGKRAEAALGRAYVTCNKNGIPFDPEKPFVTSGVRLGAPAGTTRGFKEAEFKEVGELIVEVLDGLKAANSDEGNAAVEAGVREKVIKLTDRFPMYGYM
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHMT 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMP8A_HUMAN
Sequence: MAARPGPLWLLGLTLCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQRLGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
What is the function of this protein?
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed:22579288, PubMed:31940275).  Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:31940275).  Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A.  In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.  In addition, activates the SMAD2/3 pathway (PubMed:31940275).
What are the official names of this protein?
Bone morphogenetic protein 8A, BMP-8A.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: PROF_LITCN
Sequence: MSWQTYVDDHLMCETDGQHLTAAAIIGHDGSVWAQSANFPQFKPAEIAAIMKDFDEPGSLAPTGLHLGGTKYMVIQGEPGAVIRGKKGPGGITVKKTTQALIIGIYDEPMTPGQCNMVVERLGDYLVDQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin, Minor allergen Lit c 1.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL9_HAEIN
Sequence: MQVILLDKIVHLGQVGDQVNVKSGFARNFLIPQGKAVMATKANIEHFEARRAELEATAAANLAAAQARAAEVTALGSVTIASKAGDEGRLFGAITTRDVAEAVTAAGVKIAKSEVRLPNGPIRTLGDHDVRFQLHGEVFAALDVIVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.