PharMolix/UniProtQA huggingface dataset:
Protein: HISZ_CELJU
Sequence: MVRVVMTYADRWLLPEGVEEILPGEAKAIDSLRRKLLDLYSAWGYDMVIPPLLEYTDSLLTGSGRDIDLLTLKVTDQLSGRTLGIRADITPQTARMDAHSFNRQGANRLCYAGHVVHARPKNPLATRTPIQAGIEFYGEADLAADIEVVSLLLESLQVAGLPRLHIDLGHVGIYRAIANDAGLTTAQEQEFFELLQRKAVTEIHAWVEANIPSADKAAAFILLPSLAGGIEVLDRARSQFAHLPQVIDALDHLQQLAAVVMARYPSAELYFDLGEVRGYHYLTGIVFAAFAPGYGNPIASGGRYDHIGEVFGRARPATGFAVDITALSKLGFIGQHDVSAIAVEVNQDPQQWAAIKALRARGERVIQLTPAGQLAELKCDRQLLLLDGKYQVVPLQ
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_STRS2
Sequence: MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDIIVASVKQATPGGAVKKGDVVKAVIVRTKTGARRADGSYIKFDENAAVIIREDKNPRGTRIFGPVARELRDGGFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: COX7C_GORGO
Sequence: MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLKT
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7C, mitochondrial, Cytochrome c oxidase polypeptide VIIc.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIc family.
Protein: YOBD_SALNS
Sequence: MTITDLVLILFIAALLAYALYDQFIMPRRNGPTLLSIALLRRGRVDSVIFVGLVAILIYNNVTSHGAQMTTWLLSALALMGFYIFWIRTPRIIFKQRGFFFANVWIEYNRIKEMNLSEDGVLVMQLEQRRLLIRVRNIDDLEKIYKILIENQ
What are the official names of this protein?
UPF0266 membrane protein YobD.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DCHS_LACS3
Sequence: MSELDAKLNKLGVDRIAISPYKQWTRGYMEPGNIGNGYVTGLKVDAGVRDKSDDDVLDGIVSYDRAETKNAYIGQINMTTASSFTGVQGRVIGYDILRSPEVDKAKPLFTETQWDGSELPIYDAKPLQDALVEYFGTEQDRRHYPAPGSFIVCANKGVTAERPKNDADMKPGQGYGVWSAIAISFAKDPTKDSSMFVEDAGVWETPNEDELLEYLEGRRKAMAKSIAECGQDAHASFESSWIGFAYTMMEPGQIGNAITVAPYVSLPIDSIPGGSILTPDKDMEIMENLTMPEWLEKMGYKSLSANNALKY
What are the official names of this protein?
Histidine decarboxylase proenzyme, Pi chain.
Protein: SECD_PYRFU
Sequence: MKWRRILLNFRVIVLIFFLLISITALATRGLTFGLDISGGISITVKLEKPVDSQTMEQVKIALEQRLNTLGVKNIVVEPWGDQFVIVKVANVTEEEADQLIKTIERQGVFYAEFQGIIFATGKDILNVGSVSYDPQHSAWVVPFRLSKEAAEKFAQLALGKAGYPVDMFLDPPVNSTLVVSNRVYEAMLSKTFMLEGDMTLVERIEKAFGIKVVPYANVTPEEIAEIAKGSERIILLDVDGNLSKALKEMGFEVETRSMRSDEDVYDFIKRSLGLYGPYRVSEGLATGNPSTEVMISITAPKTDIQARQDAQVVSVVLRSGSLPVKLSIERIDYISPKLGENFKRQVLVAGIAALLVVGLIVFLHYRKIKIAIPVMFTSFSEVLIILGIAALIRWNLDLPSIAGIIAAIGTGVDQQIVITDELLGEEESRRRVKRSGVLRRMGRAFFIILASATTTIVAMSFLFKFFVGGLRGFAFTTILGVLVGIFITRPAYGEIAKVLIGERR
What is the function of this protein?
Involved in protein export.
What are the official names of this protein?
Protein-export membrane protein SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUOB_BACCN
Sequence: MAINFEELHPQEQAELERNIFFTTLEQIKGWARSNSLWPMTFGLACCAIEMMGVGSSHYDLDRFGSFFRTSPRQSDVMIVSGTVTKKMAPIVRRLYDQMPEPKWVIAMGSCATAGGPYVNSYAVVKGVDQIVPVDVYIPGCPPNPAALIYGINKLKEKIRYEAKTGKQVTNK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MNME_POLSJ
Sequence: MLARHHDPIVAIATAPGRGAVGIVRVSGKDIAPVIAAICGRALAPRQATYLPFRDAQGQVIDQGLAIHFPAPHSYTGEDVLELQAHGGPVVLQLLLARCLEAGAALNPAIGQPWLAQLRVAQPGEFTERAFLNDKIDLAQAEAIADLIDASTETAARSAARSMSGEFSLAVNTLLEQLIHLRMLVEATLDFPEEDIDFLQKADAQGQLSRLQATLTGVMQRATQGAILREGIKVVIAGQPNAGKSSLLNALAGAELAIVTPIAGTTRDKVSELIQIEGVPLHVVDTAGLREALDEVEKIGVERAWAEIESADAVLFLHDLSRRDAALPAQDTINYIAADDRIARTLANKLPENTAIIDVWNKSDLTSPAGLQQVQGGVLISAKTGAGLQTLRQRLLQVVGWQAAPEGVFMARERHVRALHHVQDQLATAGRQLQAARPALDLLAEDLRQAQRQLSEITGEFTPDDLLGEIFSRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NR0B2_RAT
Sequence: MSSSQSGVCPCQGSASHPTILYTLLSPGPRTRPMAPASRSHCLCQQHRPVRLCAPHRTCREALDVLGKTVAFLRNLPSFCLLPHEDQRRLLEGCWGPLFLLGLAQDTVTFEVAEAPVPSILKKILLEEPNSGAQGAQPPDPPQPSLAAVQWLQHCLESFWSLELGPKEYAYLKGTILFNPDVPGLHASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNISCTLLVDLFFRPVIGDVDITELLEDMLLLR
What is the function of this protein?
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity).  Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity).  Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity).  Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity).  Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity).  Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR0 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Colocalizes with NEUROD1 in the nucleus.
Protein: G6PI_XANP2
Sequence: MTSNAHATDAAFKALAIAWTTREGRILDLFAQPDRFERFSVAYGDLLIDFSKTAITDDILSQLLELARAGGVEAQRDAMFAGDHINLTEDRAVLHTALRDQASDTIQVDGIDVKPGVVETLARLGDFATGVREGRIAGARGGVITDVVNIGIGGSDLGPAMVTLALAPYHDGPRCHFVSNVDSAHITDVLKGLDPATTLFIVASKTFTTVETMTNAATARAFIVNALGEDAVGAHFAAVSTALDKVGAFGIPADRIFGFWDWVGGRYSVWSAIGLPLMLAIGPDRFREFLAGAAAMDEHFRSAVLDQNLPVLLGLIGLWHRNACGFPSRAIIPYDQRLARLPAYLQQLDMESNGKSVTRDGAAVSRPTGPIVWGEPGTNAQHAFFQLLHQGTDIVPVEFLVGAQSHEPALKDHQDLLVANCLAQSEALMRGRTLEEATAQLRAKGISEDKVAEIAPHRVFPGDRPSLTIAYATLDPFTLGRIIALYEHRVFVEAAVWGINGFDQWGVELGKELATQFLPAVTGGALPPSASASTSGLIAHLDAVAGG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_HALHL
Sequence: MSDHYAVVGNPIAHSKSPQIHTRFAAEVGADLHYHRLWAPEDHFAPVAEAFFAGGGHGLNVTVPFKGAAYTFADTLSDRARAAGAVNTLRAEPDGRHFGDNTDGIGLLRDLQTNHGIDLAGRRLLLLGAGGAARGVLHDLLGEDPRTVVIANRTVDRAEALAGNDHRIRACGFDVLAGERFEVVINTTAAGLQGEMPPLPDDLLAPGATAYDLVYADEDTPFMAWARARGAVTVCDGLGMLVEQAAESFYQWRGTYPQTAPVIEALRIGA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MRAY_POLAQ
Sequence: MLLILAQWLQDDFGFFRVFNYITFRAVMATVTALLIGLAAGPWVIRKLSELKMGQAVRTDGPLTHLVKSGTPTMGGVLILIGIFVSCMLWADLSNRFIWIVMIVTFGFGAVGWVDDYRKVVRKDPKGMASREKFFWQTLIGLFAAIYLAFSVSEINNLKVLELFFEWVKSGFALDLPAKTNLLLPFMKEVSYPLGMMGFIILSYLVIVGSSNAVNLTDGLDGLVIMPVILVGAALGAFAYVMGNAIYAKYLLFPYIPGAGELMIFCGAMGGAGLAFLWYNTHPAQVFMGDVGALALGGALGTIAVIVRQEIVLFVMGGIFVAETVSVMMQVVWFKITKKHFGEGRRIFRMAPLHHHFELGGWKETQVVVRFWIITILLVLIGLSSLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SRBD1_HUMAN
Sequence: MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMPRVKKNAPQISDGSEVVVVKEELNSSVAIADTALEDRKNKLDTVQTLKTAKTKQKCAAQPHTVRRTKKLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKKEENDDDFTFGQSALKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIPFIIRYRKELINNLDADSLREVQQTLEELRAVAKKVHSTIQKIKKEGKMSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQRARQLGLEGAARALLEKPGELSLLSYIRPDVKGLSTLQDIEIGVQHILADMIAKDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGENLKVLTVKVNISDGVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDSFKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKTLLLNFNCSTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIARRVQDPLAELVKIEPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNPLDQTCIHPESYDIAMRFLSSIGGTLYEVGKPEMQQKINSFLEKEGMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTDFDKPDFKRSIVCLEDLQIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEVQVLNIDIPRSRITLDLIRVL
What are the official names of this protein?
S1 RNA-binding domain-containing protein 1.
Protein: GLMS_BUCAI
Sequence: MCGIVAAVTQRNIANFLIDGIKKLEYRGYDSSGLAVIDNKNNIVRIRCVGKVNELIKKTNKKKILGSIGVAHTRWATHGKVSKENTHPHISSNIIVVHNGIIENNSTLRGFLKKQGYIFSSDTDTEVIAHLLHWEQNKKKDSLIKVIQNSIKKLDGNYSMVVIDQNNPSKLIAARSGSPLIIGLGTEENFIASDQIALLHVTKRFIYLEEGDIAIVARKEINIFNKNNSIIQREEVVSNIEYKSAKKGKYRYYMEKEIHEQPKSIRNTLKNRLTNSNKVHFSELGSKENNIFYNTEHIQIVACGTSYNAAMVSRYWFEELANIPCDVEIASEFSSRKLVVRKKSLLITLSQSGETADTLSALRYSKKLGYLGNLTICNMKSSSLVRESDFYILTKAGLEIGVASTKSFTTQLTVLLLLVAKIINSKKENNNTSKRIVQTLSILPVRIEEILKKKQLIQDMANTLANKKNMLFLGRGNQYPIAMEGALKLKEISYIHAEAYPSGELKHGPLALIDKNIPVIMIAPENSLLEKNKKNIKEICSRGGIVYVFSNQEFDYEENINTIKLPYVEELIAPIFYTIPLQLFAYYVALKKGRDIDQPRHLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEA65_ARATH
Sequence: MAAKSKNIQVVGRHIVNGVRSRAVAYGLFTSRNDHTSAYDKNVEEELQPSQVPDEMIKPDSDKYWSPHPQTGVFGPSSSSTNAKDEFRGGQEDSVMEEKAWFRPTSLEDLDKTHHS
What are the official names of this protein?
Late embryogenesis abundant protein At5g17165.
What is the protein family that this protein belongs to?
Belongs to the LEA type 3 family.
Protein: RIR2_ALHV1
Sequence: MDFIKKYLYVCDHPGFFELTQETFQNRWFPAQINLSVDVKCLSLMSEADVNFYKYLFTFLGMAETLVNFNIDELLVDFECHDIKHYYCEQMAMECVHGKVYFNILNMLFKNNLAATWEFAEAVLKDEALQKKLEWLESKIKMAKTKAEKVLIFYLIEGVFFISSFYCIGLLRVKGVMPGVCMANDYISRDELLHTRAAALLYNTMIPKEERPSSEWVVSLFKEAVEIECAFIEAKTKQVTFVSMDDIRAFLEATADRLLNSIELPRYYKSDPPQSCPLTYTGCIKNVSFFERESTEYSSFIINDL
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase small subunit, Ribonucleotide reductase small subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: VG103_BPPF1
Sequence: MNHGRQSLLPTPNPRPGLRLLCVLVRKAGHPIAQPVAVSGLPAPWAALSGRWPLALPSPFLLRETRPVPASAEVLARCVRQRETHALCARARRLPTGGLTHAR
What are the official names of this protein?
11.2 kDa protein, ORF 103.
Protein: RS2_HALOH
Sequence: MAVVTMKQLLESGVHFGHQTRRWNPKMKDYIFTERNGIYIIDLQKTVALLDKAYDYVRDMASKGKTILFVGTKKQAQETIKTEAERCGMPYVNQRWLGGMLTNFRTIKKRVKRLNELEKMEEDGLFEVLPKKEVILLKKERDKLERFLGGIRDMKNLPDVVYITDPRKESIAVAEARKLNIPIVSIVDTNCDPDLIDYIIPGNDDAIRAVKLISSKIADAVLAGKQGEQLTEEAKPEDKEDEKGQAEEKEVKEENNSANKEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RLME_PSEPF
Sequence: MARSKTSLGWLKRHVNDPYVKQAQKDGYRSRASYKLLEIQEKYKLIRPGMNVVDLGAAPGGWSQVTSRLIGGQGRLIASDILEMDSIPDVTFIQGDFTEDAVLAQILEAVGNSQVDLVISDMAPNMSGTPEVDMPKAMFLCELALDLAERILKPGGNFVIKIFQGEGFDTYLKDARKKFDKIQMIKPDSSRGSSREQYMLAWGYRGRSE
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNPO1_BOVIN
Sequence: MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLIRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEEDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
What is the function of this protein?
Functions in nuclear protein import as nuclear transport receptor.  Serves as receptor for nuclear localization signals (NLS) in cargo substrates.  May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  Involved in nuclear import of M9-containing proteins.  In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import.  Involved in hnRNP A1/A2 nuclear export.  Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5.  In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19.  Mediates nuclear import of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity).
What are the official names of this protein?
Transportin-1, Importin beta-2, Karyopherin beta-2.
What is the protein family that this protein belongs to?
Belongs to the importin beta family. Importin beta-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DADA_ESCF3
Sequence: MRVVILGSGVVGVTSAWYLSQAGHDVTVIDREPGPALETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAVRLDGTQFQLKWMWQMLRNCDTSHYMENKGRMVRLAEYSRDCLKELRAATGIEYEGRQGGTLQLFRTEQQFENATRDIAVLEDAGVPYQLLESNRLAEVEPALAAVAHKLTGGLRLPNDETGDCQLFTQRLAQMAEQAGVKFRFNTPVDKLLFEGEQIYGVKCGDEVIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPVANEDGAPVSTILDETYKIAITRFDNRIRVGGMAEIVGFNTELLQPRRETLEMVVRDLYPRGGHIEQATFWTGLRPMTPDGTPVVGRTSFKNLWLNTGHGTLGWTMACGSGQLLSDILSGRTPAIPYDDLSVARYSSGFSPARPRHLHGVHN
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: SUA5_SULTO
Sequence: MTQIIKIDPLNPEIDKIKIAADVIRNGGTVAFPTETVYGLGANAFDGNACLKIFQAKNRPVDNPLIVHIADFNQLFEVAKDIPDKVLEIAQIVWPGPLTFVLKKTERVPKEVTAGLDTVAVRMPAHPIALQLIRESGVPIAAPSANLATRPSPTKAEDVIVDLNGRVDVIIDGGHTFFGVESTIINVTVEPPVLLRPGPFTIEELKKLFGEIVIPEFAQGKKEAEIALAPGMKYKHYAPNTRLLLVENRNIFKDVVSLLSKKYKVALLIPKELSKEFEGLQQIILGSDENLYEVARNLFDSFRELDKLNVDLGIMIGFPERGIGFAIMNRARKASGFSIIKAISDVYKYVNI
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity).  Probably catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.  Shows ATP hydrolysis activity in vitro, producing AMP.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein Sua5, tRNA threonylcarbamoyladenosine biosynthesis protein Sua5.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_ESCF3
Sequence: MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPDMPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTYQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNAAPEHIEMMASLVAAYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_MYCSS
Sequence: MARLVGVDLPRDKRMEIALTYIYGVGRTRSQEILEATGIDRDLRTKDLTDDQVTQLRDYIEANLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGLPVRGQRTKTNARTRKGPKRTIAGKKKAR
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: HISX_PSEU2
Sequence: MTTPTAIRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASMADLILPRERLELALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLAAACIAGVDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQVGIDMIAGPSEILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAIVETSINGRGALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARGESLSGHARSAEYRITDPDWTAGNKEDGK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: ADF8_ORYSJ
Sequence: MEILGFTVMGGGSPAWIEVPEKSKSAFWELMRRKVHRYVIFKIDDRREEIVVEKTGAPWESYDDFTASLPADAVYDLDFVSDDNCRKSKIFFISWSPSLSCIRAKTIYAVWRNQFRHELDGVHFEIQATDPDDMDLEVLRGRANRT
What is the function of this protein?
Actin-depolymerizing protein.  Severs actin filaments (F-actin) and binds to actin monomers (By similarity).
What are the official names of this protein?
Putative actin-depolymerizing factor 8, ADF-8, OsADF8.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.