PharMolix/UniProtQA huggingface dataset:
Protein: USOM7_ACRMI
Sequence: MLSLIPFTVCAFLALITSKGGSATPSTISLECSENDVCAALETLTRRQDRLQKTLNLCTDDESQFTLTAVVKCTSVIQVPFPNRHFKMAALDLSSGICRALAQPVVASQAYTVSAEILNEAGWKGVNSGHPGLLFNAIDENNFDFVYLRPHSVSGCYQTGYMSAGVNKFVESKRCPNGPPKGGEWFPFSVTVNGQYATVYRSGVLVTTFKTHFASSRARGGVFIFNGYKNVILFRKFKTAPKHFFSKRCKEVVEFPAGYVKMDAGIGSWPKDAFCQVEFGSDGRIASYELKVDLYNFIGRDKANLGHPGVFFNAEDEDNYDFVYFRPHSVGGCFQTGYLLKGKPRFDGAKSASCPKGPPKGKTWFNVKLTVSNATPAGEVRVYLDDTLVTSFNPRYPIKRRGGVLVANGYKNVIYLRNFKIL
What are the official names of this protein?
Uncharacterized skeletal organic matrix protein 7, Uncharacterized SOMP-7.
What are the subcellular locations of this protein?
Secreted.
Protein: GCSPA_THEP1
Sequence: MNYPYIPHTDEDIRAMLEFIGVSSIEDLFSSIPVSARSSLNIPESRDEFSVFKRLKEISEVNASLEDYAVFLGAGVYKRYVPTVVYDLAMKPDFLTAYTPYQAEVSQGTLQALFEYQTMVCELTGMEVANASMYDGATALAEAALMSFRLTGKEKVVVARSVHPEYRAVLRTYLEKRGFTVVEAGYDETGRVLLEEVDEETAAIAIQYPNFFGIIEDLDYVRSRSGNALLIVVVEPVSLALLEPPGSYGADIVVGEGQSLGLPMWFGGYSLGIFATKEKYVRQMPGRLIGQTVDQDGSVTYTMILQTREQHIRRARATSNICSNHAHAALIAAVYMSVMGPDGLREVARRSYSAAHYLQERLEDMGFKLCFSGEFFSEFVFNVPEDYPERWKWMMAKKILGPLPLKGFYPELGDTALACATEVISKEDIEKLLEAMK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: MIAB_SHEPC
Sequence: MSKKLHIKTWGCQMNEYDSSKMADLLGEYQGYTLTEDASEADILLLNTCSIREKAQEKVFHQLGRWKTLKDKNPNLIIGVGGCVASQEGKAIKDRAQCVDIIFGPQTLHRLPDMIEQVRRGDKAVIDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCSKYCSFCVVPYTRGEEVSRPLDDIILEIAQLAEQGVREVNLLGQNVNAYRGATHDGSICSFAELLRFVAAIDGIDRIRFTTSHPIEFTQDIIDVYEDTPELVSFLHLPVQSGSDRILTAMKRGHMAIEYKSIIRRLRKAREGIQISSDFIIGFPGETKEDFADTMKLIEEIGFDHSFSFIYSARPGTPAADLPDNVDMEEKKQRLAILQDRITQQAMRYSRHMMGTVQRILVEGPSVKNPMELRGRTENNRVVNFEGLPKHIGTFVDVEIVDVYTNSLRGKFIRGEDEMDLRRSLRPSDILAKHKQDDDLGVTQFKP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_ECO7I
Sequence: MKSGRFIGVMSGTSLDGVDVVLATIDEHRVAQLASLSWPIPVSLKQAVLDICQGQQLTLSQFGQLDTQLGRLFADAVNALLKEQNLQARDIVAIGCHGQTVWHEPTGVAPHTLQIGDNNQIAARTGITVVGDFRRRDIALGGQGAPLVPAFHHALLAHPTERRMVLNIGGIANLSLLIPGQPVGGYDTGPGNMLMDAWIWRQAGKPYDKDAEWARAGKVILPLLQNMLSDPYFSQPAPKSTGREYFNYGWLERHLRHFPGVDPRDVQATLAELTAVTISEQVLLSGGCERLMVCGGGSRNPLLMARLAALLPGTEVTTTDAVGISGDDMEALAFAWLAWRTLAGLPGNLPSVTGASQETVLGAIFPANP
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: DNAA_HELPY
Sequence: MDTNNNIEKEILALVKQNPKVSLIEYENYFSQLKYNPNASKSDIAFFYAPNQVLCTTITAKYGALLKEILSQNKVGMHLAHSVDVRIEVAPKIQINAQSNINYKAIKTSVKDSYTFENFVVGSCNNTVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNAIGNHALEKHKKVVLVTSEDFLTDFLKHLDNKTMDSFKAKYRHCDFFLLDDAQFLQGKPKLEEEFFHTFNELHANSKQIVLISDRSPKNIAGLEDRLKSRFEWGITAKVMPPDLETKLSIVKQKCQLNQITLPEEVMEYIAQHISDNIRQMEGAIIKISVNANLMNASIDLNLAKTVLEDLQKDHAEGSSLENILLAVAQSLNLKSSEIKVSSRQKNVALARKLVVYFARLYTPNPTLSLAQFLDLKDHSSISKMYSGVKKMLEEEKSPFVLSLREEIKNRLNELNDKKTAFNSSE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_PARPJ
Sequence: MEQFHGTTIVSVRRGDKVALGGDGQVTLGNIVMKGGAKKVRRIYNGKVLVGFAGGTADAFSLLDRFEAKLEKHQGNLTRAAVELAKDWRTDRMLRRLEAMLITADATTTLVITGNGDVLDPEGGICAIGSGGAYAQAAATALAHNTELSPREIVEKSLEIAGDMCIYTNHNRVIETIE
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIC_PSYIN
Sequence: MDITITPLASSTLWSADITPTTCSENLLDWLLDQNSLTRKLQALSADFKVKVRQQVTLSHSKDLLSPYFSEENKVLVREVLLVCDNKPVVFAQTEIPFSTLTDQQAKLAEIGTDSLGTFLFQDPSMRRDKIEVAQFPVYSAVHQLCIDLNQEVDFPLWGRRSLFYVNNKPLLVSEVFLPASGIYLP
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTGES_RAT
Sequence: MTSLGLVMENSQVLPAFLLCSTLLVIKMYAVAVITGQVRLRKKAFANPEDALKRGGLQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWIHFLVVLTGRVVHTVAYLGKMNPRIRSGAYVLAQFACFSMALQILWEVAHHL
What is the function of this protein?
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway.  Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10869354, PubMed:11067848).  Plays a key role in inflammation response, fever and pain (By similarity).  Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2.  In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
What are the official names of this protein?
Prostaglandin E synthase, mPGES-1, Glutathione peroxidase PTGES, Glutathione transferase PTGES, Inducible prostaglandin E synthase, Microsomal prostaglandin E synthase 1.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm, perinuclear region. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment.
Protein: HIS8_RHOP2
Sequence: MSRPVPKPGILDIAPYTPGKSPVPEAGRKVFKLSANETPFGPSPHAIAAYKSAADHLEDYPEGTSRVLREAIGRAYGLDPDRIICGAGSDEILNLLAHTYLGPGDEAISSQHGFLVYPIATLANGATNVVAPEKDLTTDVDAILSKVTPNTKLVWLANPNNPTGTYIPFDEVKRLRAGLPSHVVLVLDAAYADYVSKNDYEIGIELVSTTDNTVLTHTFSKVHGLASLRIGWMFGPANIVDAVNRIRGPFNTSIPAQLAAVAAIQDTAHVDMSRVHTEKWRDRLTEEFTKLGLTVTPSVCNFVLMHFPTTAGKTAADADAFLTKRGLVLRALGNYKLPHALRMTIGTDEANELVIAALTEFMAKP
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: FOLD_BACLD
Sequence: MTATIIDGKETAKEKRGQLAKEVEELKKQGVTPGLAVILIGDDPASLSYVRGKKKAAEAMGIRFQLDHFDASFTEQELLEVIDQYNQNDDFHGILVQLPLPDHISEQAVIERISPEKDVDGFHPLNVGKMLLGEDTFLPCTPAGIVELLKKTEIDLSGKEVVVVGRSNIVGKPVGQLLLNENATVTYCHSRTADITAHTKKADILIVAVGKANFIKADQIKEGAVVIDVGVNRLDNGKLAGDVDFEEAKEKASYITPVPGGVGPMTITMLAHNTVKSAKRTIQL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: Y4073_PSEAB
Sequence: MRSQDLHQRLADLGAKPLHCGRIVRAWLQGRALDACTARQPAEDFLPLGVRHGLPQVAAELEGIARLHSEHPASDGSSRLLVELADRQMVESVLLPRGGLCVSTQVGCAVGCVFCMTGRSGLLRQVGSLEMVAQVVLARRRRAVKKVVFMGMGEPAHNLDNVLEAIDLLGTDGGIGHKNLVFSTVGDPRVFERLPLQRVKPALALSLHSTRAELRRQLLPKAPPLSPEELVEAGEAYARRVDYPIQYQWTLLEGINDSLEEMDGILRLLKGRFAVMNLIPYNSMDGDAYRRPSGERIVELVRYLHSRGVLTKVRNSAGQDIDGGCGQLRARATQGTAERRIPARQA
What are the official names of this protein?
Probable RNA methyltransferase PA14_40730.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_HELPS
Sequence: MGYIPYVIENTDRGERSYDIYSRLLKDRIVLLSGEINDSVASSIVAQLLFLEAEDPEKDIGLYINSPGGVITSGLSIYDTMNFIRPDVSTICIGQAASMGAFLLSCGAKGKRFSLPHSRIMIHQPLGGAQGQASDIEIISNEILRLKGLMNSILAQNSGQSLEQIAKDTDRDFYMSAKEAKEYGLIDKVLEKNVK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REX_DESRM
Sequence: MKALKIPEATITRLSIYSRFLKRLDKKGITTVSSGDIAEGVGVSPAQVRKDLAYFGEFGTRGVGYNVKDLIRYTVKILGLSDPWNLVMVGAGNLGSALVTYREFKDRGFSIVGVFDNDLTKIGKRIADMEVLPLEELSRVVKEHNVRIGIIAVPSKAAQDIADIMVKAGLEALLNFAPISLNLPDDVEVRNVDLSVKLEILTFNLALKEK
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_ECOSE
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQPVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DP2L_METAR
Sequence: MPPKTSEAQEAYFKKLEAEFLHCREIATAARRKGYDPSLEVEIPSATDLADRVEVIMGVPGLAAHIRKCEEKMSREEASLQVAADIAEGLVGKFKDEEEAVQCAVRTAVAVLTEGVVAAPLEGISAVKLAKNDDGTEYIKVYFAGPIRSAGGTAEALAVLAADYVRRKTGRAPYKIRDVEVERFVEEIMLYKSIAHLQYTPTDEEIRLIVRNCPVCIDGEPTEQEEVQGYRNLERVETNRVRGGIALVIAEGIILKAPKVKKHVDKLKFDGWEWLDKIIAGSKPAGGENKEEEKKIKPKDKFLADLIAGRPVFGHPSRAGGFRLRYGRSRNTGFATAGIHPASMTIMDDFIATGTQLKVERPGKAAAMVPVDSLEGPTVRLFNGDVVRISDEKTALKVRPDVSQILDNGEIIINYGDFLENNHTFVPSPYVEEWWIQDLEEKTKDKVEVNSPEEAFAVSEKYGVPLHPKYTYMWMDLTTDDVVYLARYISASGMVENGELRLPVEQRSKSLLEILLIPQKVRDNTVILSAEDTYILCRCLGLNPDLSMKNPDAYAGLDSHAWKAVSALCGVTVMDRAPARIGARMGRPEKSKLREMKPPVHVLFPVGEAGGMRRSLQDASAYSKSMTDRIGEIEVEVGRRKCPDCGKMTYMVACECGGHTIPVYGCPDCGISGIEGDCPKCHKPTTPNVKQKIDVKGLYAAALKRVGERDNFEVLKGVQGLISKEKTPEPLEKGILRAKHEVFVFKDGTIRYDMSDVPLTHFIPREIGLSVEKARELGYEKDTYGAPLESPEQVCELRVQDIILSHDASNYLLKVCAFLDDELEKYYGLPRYYNVHEEQDLIGHLVIGLAPHTSAGVLGRIIGFVSSSAGYAHPFFHAAKRRNCDGDEDCVMMLMDGLLNFSLSYLPDRRGGKMDAPLVLSMRIDPKEIDKESHNIDVMARYPKEFYLATREFKAPKDVEKIMDLVSKRLGTPEQYEGFKFTHGTSDIAAGPANSAYKTLGSMEDKLKAQLELGRRLRAVDEKDVAERVINSHFLPDLIGNLRAFSTQQMRCVKCGERYRRPPLTGTCPRCGGGRVILTVHEGAVTKYMDVSLAIAKEYGVPSYTIQRLELLSLSIKSLFENDKSKQTGLADFM
What is the function of this protein?
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.  Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase II large subunit, Pol II, Exodeoxyribonuclease large subunit.
What is the protein family that this protein belongs to?
Belongs to the archaeal DNA polymerase II family.
Protein: RL13_KLEP3
Sequence: MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNAEKVAVTGNKREDKMYYHHTGHIGGIKEATFEEMIARRPERVIEIAVKGMLPKGPLGRAMYRKLKVYAGNEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PHS_MYCTO
Sequence: MAVLTDEQVDAALHDLNGWQRAGGVLRRSIKFPTFMAGIDAVRRVAERAEEVNHHPDIDIRWRTVTFALVTHAVGGITENDIAMAHDIDAMFGA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: ES1GA_ODOGR
Sequence: GLFSKPAGKGIKNLIPKGVKHIGKEVGKDVIRTGIDVAGCKIKGEC
What is the function of this protein?
Antimicrobial peptide active against the Gram-positive bacterium S. aureus (MIC=12. 5 uM) and against the Gram-negative bacterium E. coli (MIC=6 uM).  Has no antifungal activity against C. albicans.  Shows hemolytic activity against human erythrocytes only at high concentrations (LC(50)=210 uM).
What are the official names of this protein?
Esculentin-1GRa.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Esculentin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NOT1_YEAST
Sequence: MLSATYRDLNTASNLETSKEKQAAQIVIAQISLLFTTLNNDNFESVEREIRHILDRSSVDIYIKVWERLLTLSSRDILQAGKFLLQENLLHRLLLEFAKDLPKKSTDLIELLKERTFNNQEFQKQTGITLSLFIDLFDKSANKDIIESLDRSSQINDFKTIKMNHTNYLRNFFLQTTPETLESNLRDLLHSLEGESLNDLLALLLSEILSPGSQNLQNDPTRSWLTPPMVLDATNRGNVIARSISSLQANQINWNRVFNLMSTKYFLSAPLMPTTASLSCLFAALHDGPVIDEFFSCDWKVIFKLDLAIQLHKWSVQNGCFDLLNAEGTRKVSETIPNTKQSLLYLLSIASLNLELFLQREELSDGPMLAYFQECFFEDFNYAPEYLILALVKEMKRFVLLIENRTVIDEILITLLIQVHNKSPSSFKDVISTITDDSKIVDAAKIIINSDDAPIANFLKSLLDTGRLDTVINKLPFNEAFKILPCARQIGWEGFDTFLKTKVSPSNVDVVLESLEVQTKMTDTNTPFRSLKTFDLFAFHSLIEVLNKCPLDVLQLQRFESLEFSLLIAFPRLINFGFGHDEAILANGDIAGINNDIEKEMQNYLQKMYSGELAIKDVIELLRRLRDSDLPRDQEVFTCITHAVIAESTFFQDYPLDALATTSVLFGSMILFQLLRGFVLDVAFRIIMRFAKEPPESKMFKFAVQAIYAFRIRLAEYPQYCKDLLRDVPALKSQAQVYQSIVEAATLANAPKERSRPVQEMIPLKFFAVDEVSCQINQEGAPKDVVEKVLFVLNNVTLANLNNKVDELKKSLTPNYFSWFSTYLVTQRAKTEPNYHDLYSKVIVAMGSGLLHQFMVNVTLRQLFVLLSTKDEQAIDKKHLKNLASWLGCITLALNKPIKHKNIAFREMLIEAYKENRLEIVVPFVTKILQRASESKIFKPPNPWTVGILKLLIELNEKANWKLSLTFEVEVLLKSFNLTTKSLKPSNFINTPEVIETLSGALGSITLEQQQTEQQRQIILMQQHQQQMLIYQQRQQQQQQRQQQQQHHISANTIADQQAAFGGEGSISHDNPFNNLLGSTIFVTHPDLKRVFQMALAKSVREILLEVVEKSSGIAVVTTTKIILKDFATEVDESKLKTAAIIMVRHLAQSLARATSIEPLKEGIRSTMQSLAPNLMSLSSSPAEELDTAINENIGIALVLIEKASMDKSTQDLADQLMQAIAIRRYHKERRADQPFITQNTNPYSLSLPEPLGLKNTGVTPQQFRVYEEFGKNIPNLDVIPFAGLPAHAPPMTQNVGLTQPQQQQAQMPTQILTSEQIRAQQQQQQLQKSRLNQPSQSAQPPGVNVPNPQGGIAAVQSDLEQNQRVLVHLMDILVSQIKENATKNNLAELGDQNQIKTIIFQILTFIAKSAQKDQLALKVSQAVVNSLFATSESPLCREVLSLLLEKLCSLSLVARKDVVWWLVYALDSRKFNVPVIRSLLEVNLIDATELDNVLVTAMKNKMENSTEFAMKLIQNTVLSDDPILMRMDFIKTLEHLASSEDENVKKFIKEFEDTKIMPVRKGTKTTRTEKLYLVFTEWVKLLQRVENNDVITTVFIKQLVEKGVISDTDNLLTFVKSSLELSVSSFKESDPTDEVFIAIDALGSLIIKLLILQGFKDDTRRDYINAIFSVIVLVFAKDHSQEGTTFNERPYFRLFSNILYEWATIRTHNFVRISDSSTRQELIEFDSVFYNTFSGYLHALQPFAFPGFSFAWVTLLSHRMLLPIMLRLPNKIGWEKLMLLIIDLFKFLDQYTSKHAVSDAVSVVYKGTLRVILGISNDMPSFLIENHYELMNNLPPTYFQLKNVILSAIPKNMTVPNPYDVDLNMEDIPACKELPEVFFDPVIDLHSLKKPVDNYLRIPSNSLLRTILSAIYKDTYDIKKGVGYDFLSVDSKLIRAIVLHVGIEAGIEYKRTSSNAVFNTKSSYYTLLFNLIQNGSIEMKYQIILSIVEQLRYPNIHTYWFSFVLMNMFKSDEWNDQKLEVQEIILRNFLKRIIVNKPHTWGVSVFFTQLINNNDINLLDLPFVQSVPEIKLILQQLVKYSKKYTTSEQDDQSATINRRQTPLQSNA
What is the function of this protein?
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.  The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes.  Preferentially affects TC-type TATA element-dependent transcription.  Could directly or indirectly inhibit component(s) of the general transcription machinery.
What are the official names of this protein?
General negative regulator of transcription subunit 1, Cell division cycle protein 39.
What is the protein family that this protein belongs to?
Belongs to the CNOT1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RP54_CERSP
Sequence: MDMMQFQRQTTQLAMTQRMQESLRILQMSNADLADYLTAQALENPCLEVRVPEGASVAPALPSRGIQAGLDRDAFATVEGQPPSLLAHVEAQIDLAFFDPGDRRTALAFAEALEPSGWLGQPVSEVAAAAEVEEEEALVILERLQALEPAGLFARSLAECLALQLEDLGLLTWELRTMLDHLPLLAEGRIADLARRCDCEPEHIRENLALIRSLSPKPGEAFAADRTPIQPPDVRVLRGPEGWEVELTRAQLPRIRVSEAGDTGDRQADAWLARARSQARWLERAVERRQATLLRTAVCLVRHQADFLDQGPRALRPLSMEEVALELDLHPSTISRATATRLIETPRGLIPLRAFFSRSVSSDGPEAPQSQDALMALVREIIAREDRTKPFSDDAIVKQAKLAGAVLARRTVTKYRETLGIPSSYDRKRAAAAA
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is responsible for the expression of the nitrogen fixation genes.  The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein NifA for the expression of the nitrogen fixation proteins.
What are the official names of this protein?
RNA polymerase sigma-54 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: ACKR4_BOVIN
Sequence: MAVEYNQSTDYYYEENEMNDTHDYSQYEVICIKEEVRKFAKVFLPAFFTIAFIIGLAGNSTVVAIYAYYKKRRTKTDVYILNLAVADLFLLFTLPFWAVNAVHGWVLGKIMCKVTSALYTVNFVSGMQFLACISTDRYWAVTKAPSQSGVGKPCWVICFCVWVAAILLSIPQLVFYTVNHKARCVPIFPYHLGTSMKASIQILEICIGFIIPFLIMAVCYFITAKTLIKMPNIKKSQPLKVLFTVVIVFIVTQLPYNIVKFCQAIDIIYSLITDCDMSKRMDVAIQITESIALFHSCLNPVLYVFMGTSFKNYIMKVAKKYGSWRRQRQNVEEIPFESEDATEPTSTFSI
What is the function of this protein?
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor.  Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25.  Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization.  Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization.  Negatively regulates CXCR3-induced chemotaxis.  Regulates T-cell development in the thymus (By similarity).
What are the official names of this protein?
Atypical chemokine receptor 4, C-C chemokine receptor type 11, C-C CKR-11, CC-CKR-11, CCR-11, CC chemokine receptor-like 1, Protein PPR1, Putative gustatory receptor type B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).
Protein: RS19_META1
Sequence: MARSLKKAPFVYDHLMKKVVAILENKSPKRPIKTWSRRSTIYPDFIGLTFQVHNGKAFIDVFVTNDMVGHKLGEFAPTRTFSGHGADKGKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: HISX_BUCAP
Sequence: MKYFNTIVNWNMLNSNEQKNILLRPVIKNNNSIKKKVKKIIENIQVLGEKALREYTILFEKCHINKFEVSKEKMLSSSLYVNQSLKDAISTAKKNITSFHTAQILSPIDIETQVGVRCQQIYLPLNSVGIYIPSGIAPLFSTVLMLAIPAKIAGCKQIILCSPPPIDNTILYAANICGVDKIFQMGGAQAIAALAFGTKNIPKVDKIFGPGNAYVTEAKLQVSSIFNGPQIDMLAGPSELLIIADEASNADFIAADLLSQAEHSISSQVILLTPSLQLAKKVIISINNQLKNLSKSDDISTALDNSVIILTKDLFECIKISNIYAPEHLIIQTKEPRLILKEILNASSIFLGPWSPESAGDYASGTNHVLPTYGKSVSSSALGLCDFKKRVLIQELTSQGFINLSNTLKILSEAEKLEAHKNAVKIRVDFLKEKI
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: HLH15_CAEEL
Sequence: MLMEDGGLDTTSEEYRKLSKAERRKRRRATPKYRNLHATRERIRVESFNMAFSQLRALLPTLPVEKKLSKIEILRFSIAYISFLDNLLQ
What is the function of this protein?
Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (By similarity).  Involved in modulating physiological aging, probably by regulating expression of branched-chain amino acid transferase-1, bcat-1 (PubMed:26620638, PubMed:32203922).
What are the official names of this protein?
Helix-loop-helix protein 15.
What are the subcellular locations of this protein?
Nucleus.
Protein: YUAZ_ECOLI
Sequence: MRLYACCGLLLCPAYPQHFAHGYVDKIPGYPGRAGTLTGLHPMQVCRCRRPPHPVTFRRFSSTRCGFGAAPAFVCGRPVTGAARPDGGRM
What are the official names of this protein?
Uncharacterized protein YuaZ.
Protein: COBS_PSEAB
Sequence: MREALRSLLVALQFLTRLPVRLSAMPTPEQFGRAVLCYPLVGVLIGVVLYAAARSLDGTPPLLQAALLLSLWVALSGALHLDGLADMADAWVGGLGDRERTLAIMKDPRSGPVAVVVLVLVLLLKFSALAALLGQGEAGLLPLAPWLARSSLPLLFLTTPYARPGGLGQAIAEHLPARSLPWVLGGSFGLALAFGLAGLLALLVTLMLFAWLRSRFLARLGGTTGDTAGALVELTECAVLVALAL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.