Protein: DPMPA_MACPH
Sequence: MSVELPSLVVCGPQLEEIPDATYLARLRSSLLHDPYLRSLKQEALELHEMWPLLSATEPSLARFDAAPLLHSFAEWIRTGDSHVLRLAGGTLRNTQLALLTVLAHLLEYTTYLQHRHHHDHAQSEHAVLTAVHDGGVQGLSIGVLSAIAISCSQSRMHLARYGAVALRLAVCAGAWKDLDEMHAAEPPVCLEARWEGGGARAFKAVLDSYPQAYAHVREDASNATVIVPESSAAAMARKLEEDGIEARQVGLQGLSHRPDHFAACQKLFNLCSSLPMLRFPEHCHPLVPLTRNGNAEAVDDGASLHEMALRCILLEKPDSAAITAQCVAAISRQAGEPRVLLLGRVECIPRSVPARLIRPMAAGHSLYVYPDESIAIVGASCRFAGSETPAGFWDTLRERRSTLGKAPVWRGYGSEEEPFWGNFLASAGAFDHAFFRKSPREAAYMDPQHRLALHLAYEALESGGYFNPAAGTQTYDVGCYVGVYSSDYEDNVNARPPTPFSFTGTARAFASGRISQFFGWTGPSLIVDTACSSSGVAIHTACKAIQSGECTMALAGGVNLMTSPKSHQNLAAASLMSRTGQCKPFDASADGYCRGEGGGFVLLKRLSSAVADNDRVLGVLAASAINNSKGSLTITAPSLESQAALYQSVLRKAGMQPDQVSYVEAHGTGTQKGDPVECHSLRRVFGRSSRNSPPLRFGSVKGNIGHSEGASGVASLVKVLLMLQHGLIAPQANFSVLNPAAPNLEEANMEIPLYLQPWDAAFRAACVNNYGAAGNNTAMIVCQPPATQPVSRPSSVQKRHQYPFMLTAHSDASLRQHCRILLQFVEDQQAWAGDDLLASLAFHLAQRQSHQLGYRTAFSARSIDDLKARLGEQNTQTRGNCNPVVLVFAGQTGHRPRLSEEAYHSSFLLQHHLDRCDRTLQTLGLRGLFPQVFGTQAVDDLVDLHCMLFSIQYATAAAWIDAGLDVRKLVGHSLGQLTALCVARVLTLRDALKMISGRAALIQSKWGPEQGCMLSVDSDAVTVRALIDSMASEEKVEIACYNAPSSHVVVGKAGATAAFESAALSAGVRTKRLAITHAFHSPMVDSIMEDYESLLRELQFHSPTIPIEPCEQSGGSWENLTPERVARQSRAPVYFGAAVSRVERELGSCVWLEAGAGPAGVTMARRAASSSSHAFLSARLGSPDAMDSLADTTLSLWREGVRVQFWPFHPWQRHCFRLLELPPYQFETTHHWLPFASAPESAAQQPTTANDVAPQLVSVVRSSGGADPEAAEFTINQHSEEYALFVGGRTVLGHALSPPSVYLESAARALGLVSAAAGGPAALPPHFEQVQLHAPLGIDPRRRIRLRLQKHNTSAWEFVFDSQAPALDGGQTFQLQASGIIKSQEQDRAVAGPYRPLLRRLIDHERCRVLLEDSGASVVQGAFVKNILGRVASYEDSYFGIRSITSKGHEAVGVVDVPEIAHQRCAETRVNPPLLDNFMLVAEMHAGNLDACGSDQMYVCNGFDALVPHSNDGSLRGPFTVYSKLERESDRVFVGDVFVLTGGQKTLSLAILGARFSKVPVRSLQRALEAANGSPNVRTAEALDHSAVAIEARDSALTSPPIRPHAPPSSDAVSTISLNEVKTTTERVISETTGVPRERINDATLLGDLGVDSLMATELQVRFSDVLHVDLAIGTLCEHGMTAGRLCQEIHSRLSGVPQLSPHDTDRSSDLSAGQPPSTPKASTQEQEHFIVELSKLLAEHLNCSPDIPPETPLALMGLDSLLAIQLASDMESRFGKKSSPMNIDENTTFSDLCRVLSGADLPGFPRTSDNRRSEEGSVGHVGPEKSEASFFREREDVIKLEFDRAKQRYGVFSEQAGLAGFYARVYPRQMALVLAYIVEAFRTLGCDVATLRAGERLPPIPHEPRYEKLVRRYLQLLEDAGLITSSGEHPPAHLRTAKALEHAESSRLHRAILADFPAYRPDHRLLQLTGPRLADCVSGKVDPLQLLFHGPASRQLLEAFYVSSPMFATATRMMSEFVGQLLRKHGGCSERLRVLEVGAGTGATTQQLLDQLVASGAAFTYTFTDVSSSLVAAARRRLEARYAAAGHEMHFAVLDIERPPPQRLLHSQDLVVASNVLHATRSLSDTCSNVQRLLRPGCGVLCLLELTRPLPWLDCVFGLLDGWWRFADSRTYPLVDEWRWKACLLNAGFRHVDWTDDESREADLFRWILALA
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpmpA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpmpD through the action of the prenyltransferase dpmpC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpmpE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpmpB (Probable).  The short chain dehydrogenase/reductase dpmpG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpmpH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Higginsianin B is further methylated by the methyltransferase dpmpI to produce the intermediate named FDDP B (PubMed:32286350).  The cytochrome P450 monooxygenase dpmpJ then oxidizes the C-26 methyl to primary alcohol, producing the final diterpenoid pyrone with a C-26 primary alcohol on the gamma-pyrone moiety named FDDP C (PubMed:32286350).
What are the official names of this protein?
Non-reducing polyketide synthase dpmpA, Diterpenoid pyrone biosynthesis cluster protein A.