PharMolix/UniProtQA huggingface dataset:
Protein: Y2259_STAAW
Sequence: MLYPIFIFILAGLCEIGGGYLIWLWLREGQSSLVGLIGGAILMLYGVIATFQSFPSFGRVYAAYGGVFIIMSLIFAMVVDKQMPDKYDVIGAIICIVGVLVMLLPSRA
What are the official names of this protein?
UPF0060 membrane protein MW2259.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLVS2_HUMAN
Sequence: MTHLQAGLSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLLAQYFEYRQQNLDMFKSFKATDPGIKQALKDGFPGGLANLDHYGRKILVLFAANWDQSRYTLVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTWARTLLDHEYDDDSEYNVDSYSMPVKEVEKELSPKSMKRSQSVVDPTVLKRMDKNEEENMQPLLSLD
What is the function of this protein?
Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity).  Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
What are the official names of this protein?
Clavesin-2, Retinaldehyde-binding protein 1-like 2, clathrin vesicle-associated Sec14 protein 2.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Early endosome membrane; Peripheral membrane protein.
Protein: PSBX_MICAN
Sequence: MTPSLANFLWSLVLGAAIVLIPATIGLIFISQYDKIKRT
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: IL36A_HUMAN
Sequence: MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF
What is the function of this protein?
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response.  Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.  Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation.  In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6.  In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6.  In myeloid dendritic cells involved in cell maturation by up-regulating surface expression of CD83, CD86 and HLA-DR.  In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation.  May play a role in pro-inflammatory effects in the lung.
What are the official names of this protein?
Interleukin-36 alpha, FIL1 epsilon, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: MSRA_BRUA1
Sequence: MSFFDSYRKKMQMPSKEEVLPGRVQPIPTAAAHFVSGHPLKGPWPDGMKQVLFGMGCFWGAERLFWQVPGVYVTAVGYAGGITPNPTYEETCTGLTGHAEVVLVVYDPKVVTLNELLALFWEEHDPTQGMRQGNDIGTTYRSVIYTFNAVDRAVAEKSRDAYSQALASRGLGPVTTQIADAPDFYYAEDYHQQYLAKNPDGYCGLRGTGVSCPIPLAH
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: GSHR_CANGA
Sequence: MIVKRLFRTMAPVAKHFDYLVIGGGSGGVASSRRAASYGAKTLLIEGKALGGTCVNVGCVPKKVMWYASDLATRLTHAHEYGLAQNVPLSKESITFNWPEFKKKRDAYIHRLNGIYENNLKKEGVEVVFGWAKFNKDGNVEVTKHDNTTEVYSADRILVATGGKPVYPEKVPGFELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSDSHLVIRGKTVLRKFDEIIQNTVTDYYVEEGINVHKETNVDKVEKDEKTGKLSVHLTNGQVLEDVDELIWTMGRRSLLGIGLENVGVKLNDKEQIITDEYQNTNVPNIYSLGDVSGRVELTPVAIAAGRKLSNRLFGPEQYRNDKLDYTNVPSVVFSHPEAGSIGLTEDEAIKQYGKDNIKVYTSKFTAMYYAMLEHKSPTRYKIICEGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR
What is the function of this protein?
Maintains high levels of reduced glutathione in the cytosol.
What are the official names of this protein?
Glutathione reductase, GR, GRase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBN_CHLAT
Sequence: METATVFSIFISCLLLSLTGYSLYTAFGEPSAELRDPFEEHED
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y1324_MYCTO
Sequence: MTRPRPPLGPAMAGAVDLSGIKQRAQQNAAASTDADRALSTPSGVTEITEANFEDEVIVRSDEVPVVVLLWSPRSEVCVDLLDTLSGLAAAAKGKWSLASVNVDVAPRVAQIFGVQAVPTVVALAAGQPISSFQGLQPADQLSRWVDSLLSATAGKLKGAASSEESTEVDPAVAQARQQLEDGDFVAARKSYQAILDANPGSVEAKAAIRQIEFLIRATAQRPDAVSVADSLSDDIDAAFAAADVQVLNQDVSAAFERLIALVRRTSGEERTRVRTRLIELFELFDPADPEVVAGRRNLANALY
What are the official names of this protein?
Uncharacterized protein MT1366.
Protein: YJDM_ECO57
Sequence: MSLPHCPKCNSEYTYEDNGMYICPECAYEWNDAEPAQESDELIVKDANGNLLADGDSVTIIKDLKVKGSSSMLKIGTKVKNIRLVEGDHNIDCKIDGFGPMKLKSEFVKKN
What are the official names of this protein?
Protein YjdM.
What is the protein family that this protein belongs to?
Belongs to the YjdM family.
Protein: LSPA_GEOSL
Sequence: MKPTYRIFNAVVLGSLVLDQATKVLIDRTMDLYQSIPVIDGLFSITYLRNRGAAFSFLADFSYRLPFFILVSVVALGVIAVTFRKLRDDQHLAAAALALIFSGALGNLIDRVRLGEVIDFLDVYWKTYHWPAFNVADSAICVGVALLAVDMIREERRKAP
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS12_ENTFA
Sequence: MPTINQLVRKPRKSKVEKSDSPALNKGYNSFKKTQTNVNSPQKRGVCTRVGTMTPKKPNSALRKYARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKDLPGVRYHIVRGALDTAGVNDRKQSRSKYGTKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RS2_KLEP3
Sequence: MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKISARKGKILFVGTKRAASEAVKEAANSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELDKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVSLYLGAVAATVREGRSQDLASQAEESFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: YE079_YEAST
Sequence: MSLRMRFKPSIENFVNLFSFSCLSFLSHEPHVYLKKASLFGSLSFVSLVKTSFGLLEINLLVAATVIHLIAPTLFEAPTTHLLEWPATVYLIMLGLRIAVLLAKQLLLLLLR
What are the official names of this protein?
Putative uncharacterized membrane protein YER079C-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AMPG4_RICFE
Sequence: MLITKIFKDYRLFEIFILGIVSGMPLVIIFSTLSVWLKESGIDIAVITTFAVARLSYSLKVFWSPLVDNFKIPFLSRWGHRKSWLILCSSLMVLVLIAMSKENPEVSLTSLYFLTIALGFLSSTFDIAVDALRIDKFDQETQTIASATAVFGYRIGMLITGAGALYLAEITGNNWQLTFVIIAIIFAVATIFIITVNEKELVREKVNITSIISWIYAVINPFKDFFKREFAVTILLAVIFFKLGDAMLGAVASPFYIELGYTKGEIAIIAKLYGLIATLVGGFAGGIVMYKVGNFKGLIITGIAQSLTHFAFIWLNHQPPSFEALLIAITIENFAAAMGATALVGYIGNLCNKKYSATQYALLSSSSSLCNNTVTIYAGKLVNMMGWDGFFIFTIILALPALFILMYLNKKVNV
What are the official names of this protein?
Putative transporter AmpG 4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNC_CLOBA
Sequence: MNRYKFNDIENRLGVYFNNPSLIKTALTHSSFGNQFKDAKYNERLEFLGDSVLQLCITEYLFNKFKDKSEGELTKIRSLIVCENSLYEIAKKLSLGEYIRMSKGEELTGGRERMSIQADAVEAVIAAVYLDKGIGFVNDFILLHFEEMINKAINNEIVLDFKTKLQELLQKDGEILIQYELLKYEGPPHRRKFFTNVIINEKVMGIGEGYSKKEAEQNAAKEALKRLEKNYE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_ACTSZ
Sequence: MDNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFNPTGIILSGGPESTTENDSPRAPEYVFDAGVPVLGVCYGMQTMAMQLGGLTEGSAHREFGYAQVDLQATDSLFAQLNDDLDSAQPKLDVWMSHGDKVTRLPEGFQVTGTTPTCPIAAMSDEKRHFYGVQFHPEVTHTKSGLALLTNFVVNICGCATNWTPENIIEDAVARIKAQVGDDEVILGLSGGVDSSVTALLLHRAIGKNLHCVFVDNGLLRLNEGDQVMEMFGDKFGLNIIRVNAEERFLDALKGIHDPEAKRKMIGKVFVDVFDEESHKQTSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHPFPGPGLGVRVLGEIKKEYCDLLRKADAIFIEELYNSGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAQLPYDLLGKISNRIINEVDGISRVVYDVSGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ISPG_CAMC5
Sequence: MQRYPTKQIKIRDVAIGGDAPIPVQSMTFSKTKDVKGTLAQIQRLYFAGCDIVRCAVLDKEDAKALREIVAKSPLPVVADIHFNHIYAVMVSEYVDAIRINPGNIGSKERIKAVVDACKQRKIPIRIGVNSGSLEKQFEERYGRSVEAMVASAMYNINLLEDFDFTDIKISLKSSDVERTMQAYRTLRPKVPYPFHLGVTEAGTTFHATIKSAIALGGLLLEGIGDTMRVSITGELEEEIKVAKAILKDSGRQREGLNIISCPTCGRLQSDLMKAIKIVEEKTKHIKEPLNVSVMGCVVNAIGEAKGADVAIAFGKESGLIMRRGEVVARLKESELVDRFLAEIDDEIKSRE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: CCMK3_SYNE7
Sequence: MPIAVGTIQTLGFPPIIAAADAMVKAARVTITQYGLAESAQFFVSVRGPVSEVETAVEAGLKAVAETEGAELINYIVIPNPQENVETVMPIDFTAESEPFRS
What is the function of this protein?
A non-essential, minor shell protein of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered.  Hexamers form sheets that form the facets of the polyhedral carboxysome.  In PCC 7942 there are several CcmK paralogs with presumably functional differences (PubMed:22928045, PubMed:25117559).  This subunit probably only makes heterohexamers with CcmK4.  The CcmK3-CcmK4 heterohexmers have been suggested to cap other hexamers, perhaps to alter metabolite flux (Probable).
What are the official names of this protein?
Carboxysome shell protein CcmK3, Carbon dioxide-concentrating mechanism protein CcmK3.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family. CcmK subfamily.
What are the subcellular locations of this protein?
Carboxysome. Note=This cyanobacterium makes beta-type carboxysomes.
Protein: GUN6_ARATH
Sequence: MEKFAPVAALLLLLLCFPVAFSGHDYGQALSKSLLFFEAQRSGVLPRNQRVTWRSHSGLTDGKSSGVNLVGGYYDAGDNVKFGLPMAFTVTMMAWSVIEYGNQLQANGELGNSIDAIKWGTDYFIKAHPEPNVLYGEVGDGNTDHYCWQRPEEMTTDRKAYRIDPSNPGSDLAGETAAAMAAASIVFRRSNPVYSRLLLTHAYQLFDFADKYRGKYDSSITVAQKYYRSVSGYNDELLWAAAWLYQASNNQFYLDYLGRNGDAMGGTGWSMTEFGWDVKYAGVQTLVAKFLMQGKAGRHAPVFRKYQEKADSFMCSLLGKSSRNIQKTPGGLIFRQRWNNMQFVTSASFLTTVYSDYLTSSRSNLRCAAGNVAPSQLLSFAKSQVDYILGDNPRATSYMVGYGNNFPQRVHHRGSSIVSVKVDRTFVTCRGGYATWFSRKGSDPNLLTGAIVGGPDAYDNFADRRDNYEQTEPATYNNAPLLGVLARLSSGHSGYSQFLPVVPAPVVRRPMPIRRPKVTTPVRASGPVAIVQKITSSWVSKGRTYYRYSTTVINKSSRPLKSLNLSIKNLYGPIWGLSRSGNSFGLPSWMHSLPSGKSLEFVYIHSTTPANVAVSSYTLA
What are the official names of this protein?
Endoglucanase 6, Endo-1,4-beta glucanase 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLMU_ECO8A
Sequence: MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLAHGRDIEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTIVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEP2_ARTOT
Sequence: MHGLLLAGLAVALPLGVAGHPARPQTALSPRGIDVNAYRFTSTAKYNEHKTTSQMVQSFAYSKDDDYVATATKLVKSTFPNMTFRTVKDHYIGTNGIGHVHFKQTAHDIDIDNADFNVNIGRDGKVFTFGNSFYQGEMPKTNPMVKRDYSDPVKALHGAIKTLKIPVKPESAKAMPMDEVETFKFEGTSGALSEPKAKLVYIQKDGNLHLTWRVETDVGDNWLLSYVDSKESETVHNVVDYVASADYKVFAFGLNDPTEGQPSMIKDPWNTTGSGSPFTWHGDGKTDYTVTRGNNVAAQDNPSGGSQWENNYRPDSPQLSFVYDYSDQMEPEDYKDFAITQLFYTTNTFHDVLYSLGFTEEAGNFQVNNGNKGGKGNDFAICNAQDGSGTNNANFATPPDGQPGRMRMYTWTTSKPKRDGDLEAGIVIHEYTHGLSNRLCGGPANSNCLNDLEAGGMGEGWGDFYATAIRLKQGDTHDTDYTMGEWAANQKGGIREYPYSTNMQTNPYTYADVKGMREVHGIGTVWATILYDVLWNLIDDHGMGKNVMPKMVDGVPTDGRTLAMKLVLDGMTLMPCNPNFMQARDAIIDADMALTKGANKCSLMKAFAKRGLGSNTKPGKGYTNNFDMPSGC
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 2, Fungalysin MEP2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENTP5_BOVIN
Sequence: MALYQGAAFFMLVASCVCSTVFHREQQTWFEGVFLSSMCPVNVSAGTLYGIMFDAGSTGTRIHVYTFVQKVPDNTGQLPVLEGEIFDSVKPGLSAFVDQPKQGAETVQELLEVAKDSIPPSHWKRTPVVLKATAGLRLLPEEKAEALLFEVKEIFKKSPFLVPDDSVSIMDGSYEGILAWVTVNFLTGQLHGHNQETVGTLDLGGASTQITFLPQFEKTLEQTPRDYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETAGIDGYTFRSACLPRWLEAEWIFGGVKYQYGGNQEAGEVGFEPCYAEVLRVVQGKLHQPDEVQRGSFYAFSYYYDRAVDTDMIDYEKGGVLKVEDFERKAREVCDNLENFTSGSPFLCMDLSYITALLKDGFGFASSTVLQLTKKVNNIETGWALGATFHLLQSLGISH
What is the function of this protein?
Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (By similarity).  In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases.  UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose.  Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose.  Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity).
What are the official names of this protein?
Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Uridine-diphosphatase ENTPD5, UDPase ENTPD5.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Secreted.
Protein: PYRG_BACTN
Sequence: MGETKYIFVTGGVASSLGKGIISSSIGKLLQARGYNVTIQKFDPYINIDPGTLNPYEHGECYVTVDGHEADLDLGHYERFLGIQTTKANNITTGRIYKSVIDKERRGDYLGKTIQVIPHITDEIKRNVKLLGNKYKFDFVITEIGGTVGDIESLPYLESIRQLKWELGKNALCVHLTYVPYLAAAGELKTKPTQHSVKELQSVGIQPDVLVLRAEHPLSDGLRKKVAQFCNVDDKAVVQSIDAETIYEVPLLMQAQGLDSTILEKMGLPVGETPGLGPWRKFLERRHAAETKEPINIALVGKYDLQDAYKSIREALSQAGTYNDRKVEVHFVNSEKLTDENVAEALKGMAGVMIGPGFGQRGIDGKFVAIKYTRTHDIPTFGICLGMQCIAIEFARNVLGYADADSREMDEKTPHNVIDIMEEQKAITNMGGTMRLGAYECVLQKGSKAYLAYGEEHIQERHRHRYEFNNDYKAQYEAAGMKCVGINPESDLVEIVEIPALKWFIGTQFHPEYSSTVLNPHPLFVAFVKAAIENEKN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CTF4_YEAST
Sequence: MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQLK
What is the function of this protein?
Accessory factor for DNA replication.  It plays a role in accurately duplicating the genome in vivo.
What are the official names of this protein?
DNA polymerase alpha-binding protein, Chromosome replication protein CHL15, Chromosome transmission fidelity protein 4, Protein POB1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPB5A_ARATH
Sequence: MLTEEELKRLYRIQKTLMQMLRDRGYFIADSELTMTKQQFIRKHGDNMKREDLVTLKAKRNDNSDQLYIFFPDEAKVGVKTMKMYTNRMKSENVFRAILVVQQNLTPFARTCISEISSKFHLEVFQEAEMLVNIKEHVLVPEHQVLTTEEKKTLLERYTVKETQLPRIQVTDPIARYFGLKRGQVVKIIRPSETAGRYVTYRYVV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  Component of RNA polymerase IV which mediates short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of target sequences.
What are the official names of this protein?
DNA-directed RNA polymerases II and IV subunit 5A, RPB5a, DNA-directed RNA polymerase II subunit E, RNA polymerase I, II and III 24.3 kDa subunit, AtRPB24.3.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU6M_GORGO
Sequence: MTYVLFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCAIILNCGGGYMGLMVFLIYLGGMMVVFGYTTAMAIGEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNNVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYIVIEIARGN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ISTB_GEOSE
Sequence: MKERIHEYCHRLHLPVMAERWSAMAEYASTHNISYSEFLFRLLEAEIVEKQARSIQTLIKLSKLPYRKTIDTFDFTAQPSVDERRIRELLTLSFIDRKENILFLGPPGIGKTHLAISIGMEAIARGYKTYFITAHDLVNQLRRADQEGKLEKKLRVFVKPTVLIIDEMGYLKLDPNSAHYLFQVIARRYEHAPIILTSNKSFGEWGEIVGDSVLATAMLDRLLHHSIIFNLKGESYRLREKRLQEEKQKDQ
What are the official names of this protein?
Insertion sequence IS5376 putative ATP-binding protein.
What is the protein family that this protein belongs to?
Belongs to the IS21/IS1162 putative ATP-binding protein family.