Protein: ASQK_EMENI
Sequence: MAVSYTNFTNLPAKLYLVYRACTFTPLHAENLASNITQAMKQLLAQPDACVKDIDIFSPFNEITVSRWNAEIQEAPDASLLEVIRGHSRYRPSHTAIHAWDGTVSYSELDVTSTKWAIYLQSQGVKAGCLVPIMMDHSKWAVIGQLAILKAGGAFVPLDPGQPLFRLENIVRLTTESHISLSSPHLANRLHGLVETVLVISDERTESLPKANAHHDAADISPVVNNGPAYVLFTSGSTGRPKGCVVGYGALSDVVNQTTALKIGPDSRVLQFASYTYGMSLIEIYCTLAAGATICVPSEDDRLNALSSILLSMQVTWAILTPSTTISIADAVVCLNTLVVAGEALTMDRLHSLADKTEVIQAFGLTEWAGICCVSQRITSETDLRVIGRSHTARLRLVDPANYNRLAPVGAVAELLIEGPAMADGYLGDPEQTARAFPKTSTGGRFYRTGDLVQYAADGSLRYVSRKDSQVKIRGMRVELTEVEYQIRRAFPGVEEVVVEAAAPKNSSGIPILVAFLCPEDLSGLVCTIKETMKRSLPDYMRPSVYVPLEFIPKTISRKVDRKALRHLVQSSTRHELERYTQASLPSLVGPRTNIEQLVHELVADMLRLDPLSLGMRQNFISLGGDSVTAMLLVNKLRRKGYKITVAAILRAQSLLDVASLVHYPAGLEPSAQKSTPGDLKLVPRAIHRISDSGTVEQSFSQARIWFLQTLRPSSTWLLLPSATRLRGSLRVDALETAFSALVERHETLRTTFEDREGSGVQVVAPFHPYQLEIIEIPSGSDADLITALHGQQIRPMDLTKECWRATLFRLSPDEHVLNIVLHHIICDGWSFDIFLKTLQIYYAAALQGHSPLEGVEPLPIQYRDFSIWQRQNKARTSVEQLAYWVRQLDGSQPAEFLCDKKRPHMLSGKAGSQPVKIDVCLYHDVKRFCSMKHVTPFTVLFAAFRATHYRLTGASDATIGIPSVSRPQAELEELIGYFGNVQCIRTKVESCSSSFQLLVHQVQSSITAAFENQDVPFDQIVSKLLKDRDVSRHPLVQVAFILHTQAQFGKLRLEGLESEQLPLPHVSRLDLEFHLYPGEGGGDLQGEVLYSMDLFHAETINAMVLVFYDILREGIRKPDTSIDSLPFPGGYSILNERGLIYPQQSRSLSIIDLFDEQVRAQTDEVAVKDINGHLTYSELHKRSSMLSAWLKNSYSFAEETPVGVYASRSCESIVAILGILRAGLAYIRLDIDAPKARTEMILSCLPNCRLVLVASGLEPPRVCVQGVQFAYIADSCKETVTDVHDFLKTCTPPGPMSLAYIVFTSGTTGTPKGVMIEHHGVANLAKEPDIIAHAVNSRIASHMLNPSFDASGFEIYATLLNGGTLVCIDNSVVFDFPALGATFIQHGIRRAFMTPAILKQTLASCNSLLRMLDILYVGGDKLDPGDVAKVQRLTTGRVQIFNCYGPTENSIVSTKYRVPVDEEGVNGVPIGRSISNIGAYVVDRSLRLLPLGVLGELVVTGPALARGYIDPKHDIGRFIELDISEEVAPMRAYRTGDMVRYRPRDAQLEFFGRMDQQVKVRGYRVELAEIDNTLLLSPFISAAVTVARQDQELVSFVTVSDMASGFNDRAETEHVDSWLDVVEGEDYYGSVGTIEPHSLGADFLGWISMYDGEPIDKNDMREWLQDTITAILSCSPSSVLEIGTGSGMILFNIIGSIQKYVGLEPSPRAVDFVRRAVHWVPEAAGKVNIKCGTASDIGRLQDMGTLDLAVINSVAQYFPSLDYLRNTIKDLVRQGVKSIFLGDIRSYALYQEFQVSKVLRLYGRGLTITRFRQHMAEIARLEKELLVDPAFFTSLPAELPGMIEHVEIWPKRMKATNELSCYRYTAVLHVKRAEQPLLIREVKEISWADFQAKGWDYNSLSQMLEISDASTVLAVENIPFKKTIVERDMVRLLQELPEDTGSVSWSSNARGPKRALAPIDLFDVAKKTGWDIEISWARQRSQRGGLDAVFHRQGPRVLFRFPVDPYIPGACSNDPLSPQRNRLLEKHLLEYMSTKLPTYMVPKLIHVLDKMPINNIGKVDRHVLAQRAAITSATISESESLFRREIEPAFTSEIERAVWEEFTGVLGREVGVADSFFRNGGHSLMAIRLVSRINKRLSSALSVSELFRYPTVSGLAQHLQGLGALETRAVTVYAPFSLLDRPYDPSEVRLPPEADIVDVTPVTECQAWFLQCWSLVSHSFIIHGVLDVDRLRAACQAVVRHHPPLRTVFTEFQTQLVQAFDGVSLSAILYDIARAYGNSASPLSNAVPFSHHLHMCRSTRPDALAFWKAYLRDAVLTEVPRPEEVNATNEKPLEIIQQEALGEVSLPSTVDITFSTLVNAAIALALARLVQRNDVIFACVMTSRGVLAELAESVVGPCVNRCLLRVKVPDDSNPDSTALDFCRNLRDNQAQVSGHGHLGFRDVVENCTSWASLGVDVGRIAFVTHLPAETALETFSLTLLDSPVSYDSTNVTINPGNQILVRSAITDEQQACIQVLSSSNVMGAEKALFLANRILMIAQRLSVSVSGGRSPRLLELDK
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the aspoquinolone mycotoxins (PubMed:25251934).  The first stage is catalyzed by the nonribosomal pepdide synthetase asqK that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin (PubMed:25251934).  AsqK is also able to use anthranilic acid and L-phenylalanine as substrates to produce cyclopeptin, but at a tenfold lower rate (PubMed:25251934).  Within the pathway, 4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase asqJ.  AsqJ also converts its first product 4'-methoxydehydrocyclopeptin to 4'-methoxycyclopenin.  The following conversion of 4'-methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase asqI.  4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B.  The prenyltransferase asqH1 then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase asqF to yield conjugated aryl diene.  The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase asqH2 to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain.  The FAD-dependent monooxygenase asqG performs epoxidation of the terminal C7'-C8' olefin.  Finally, after dehydratation of the epoxide at C3 by asqC, the quinolone epoxide rearrangement protein asqO catalyzes an enzymatic 3-exo-tet cyclization to yield the cyclopropyl-THF ring system in aspoquinolone (Probable).
What are the official names of this protein?
Nonribosomal peptide synthetase asqK, NRPS asqK, 4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqK, Aspoquinolone biosynthesis protein K.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.