PharMolix/UniProtQA huggingface dataset:
Protein: PSBT_KLEBI
Sequence: MEALVYTFLLVGTLGIIFFAIFFREPPKITSNKK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ATP18_PICAN
Sequence: MKFLGVKVYRFPLVKYYWPFFVGFGLTFYGVAKIQNAMMDTAEFINDPRHPRFKKGDLEKK
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:25759169).  F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:27791192).  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).  Part of the complex F(0) domain (PubMed:27791192).  Minor subunit located with subunit a/ATP6 in the membrane (PubMed:27791192).
What are the official names of this protein?
ATP synthase subunit J, mitochondrial, ATPase synthase I subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase j subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Note=The F-type ATP synthase complex is anchored in the mitochondrial inner membrane via the F(0) domain with the F(1) domain and the peripheral stalk extending into the mitochondrial matrix.
Protein: MHPA_SHISS
Sequence: MAIQHPDIQPAVNHSVQVAIAGAGPVGLMMANYLGQMGIDVLVVEKLDKLIDYPRAIGIDDEALRTMQSVGLVENVLPHTTPWHAMRFLTPKGRCFADIQPMTDEFGWPRRNAFIQPQVDAVMLEGLSRFPNVRCLFSRELEAFSQQDDEVTLHLKTAEGQRETIKAQWLVACDGGASFVRRTLNVPFEGKTAPNQWIVVDIANDPLSTPHIYLCCDPVRPYVSAALPHAVRRFEFMVMPGETEEQLREPQNMRKLLSKVLPNPDNVELIRQRVYTHNARLAQRFRIDRVLLAGDAAHIMPVWQGQGYNSGMRDAFNLAWKLALVIQGKARDALLDTYQQERRDHAKAMIDLSVTAGNVLAPPKRWQGTLRDGVSWLLNYLPPVKRYFLEMRFKPMPQYYGGALVREGEAKHSPVGKMFIQPKVTLENGDVTLLDNAIGANFAVIGWGCNPLWGMSDEQIQQWRALGTRFIQVVPEVQIHTAQDNHDGVLHVGDTQGRLRSWFAQHNASLVVMRPDRFVAATAIPQTLGNTLNKLASVMTLTRPDADVSVEKVA
What is the function of this protein?
Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).
What are the official names of this protein?
3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase, 3-HCI hydroxylase, 3-HPP hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: TRPE_THEMA
Sequence: MGDSMHVLKLVSDLETPVSTFMKVSRGEEFAFLLESVELGSAFGRHSFIGIGKKDVLVFEKGILRTSNQQLDYTSSPLKAIKDWLEVYRYSVKHDELPSFRGGAVGFVSYDYISYIEKVKVKASVFPTFYFVVPEHLIIFDHLKNNVFIISDSPEELTSKVLSPFEEKPEKNVFVTEPESNFEREQFYKVVEKAKKYIVEGDIFQVVLSQAFTFKTTLDPFYIYRALRMINPSPYMFYLKFGDTVVLGSSPETMAKVEGDKATVKPIAGTRPRGRTVEEDLKLERELLNDEKEIAEHVMLVDLGRNDLGRVCKEGTVRVEKKMVIERYSHVMHIVSQVSGELKDDKDAVDVFEATFPAGTVSGAPKVRAMEIIEELEPTPRGPYAGAVGYFSFPDDKGRMNMDSAITIRSFFFKGKQGWLQAGAGIVYDSVPEREYQETLNKLRALFRSLEVAQKIQGGLF
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 1, AS, ASI.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.
Protein: HEM1_SYNR3
Sequence: MHLAVVGLSHRTAPVEVRERLSIPEHHLETSLQSLRSHEQVLETSILSTCNRLEIYSLLRHPEDGVEAIRDFLANHSGLADPDLQPHLFALHHEEAIQHLLRVSAGLDSLVLGEGQILSQVKKMYRLGQDHKSIGPILNRLLNQAVSTGKRVRSETNLGSGAVSISSAAVELAQLKVGQEQGVDDLVSLSQEKVAVVGAGRMARLLLQHLQSKGARSITVVNRTVAKAEVLAKDFPDLVITCCGLDQLDAQLASNTLLFTSTGADEPIIDRQRLDAITRQARLMLVDIGVPRNISSDAADVSGTLSYDVDDLQEVVERNVAARQQLAQQAEVLLDEDRQAFLDWWDGLEAVPTINRMRQQFEEIRKQELLKALSRMGSDFSQREKQVVEALTKGLINKILHGPTTALRAPQPRQQRLDSMAAAQRLFDLPGDDADRDRSDAK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RFX2_XENTR
Sequence: MQNSDSGSDSATSVALRTSASAQAPVVQPVPASQQVQTVQHVYPAQVQYVEGDTVYTNGAIRTAYSYNAEAQIYAPSSGSSYFDSQGGGAQVTTVVSSPTAIPSHSMVGIAMDVSGSQIISSSGAYLIHGGLENSRHTPSHTSRTFPATLEMAIENLQKNEGITSHKSSLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQDHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAIRQQPIHQKQRYRPAQKMDGMGENTANSSQHTSPEQSVAAQSQHHQQFIDTAHVFPDFPEPDLGNVLLPEGITMTDIKNLQLMYRRHCEATIDVVMNLQFQYIEKLWQAFWNSKPSSPDGSNPMNSEDEQEPIIPKDKLMVLCKYEPIMRWMRNCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMCDFPQQIVHAKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEEGMVQKLEQDFKLTLQQQSSLDQWANWLDNVVTQVLKPHEGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFSDFASMSPVLMDKDDVSELGSDNDGDPRISGQPPVKRERVDLNHSMQEM
What is the function of this protein?
Transcription factor that acts as a key regulator of ciliogenesis.  Specifically regulates expression of genes required for cilium assembly and function.  Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters.  Required for neural tube closure and neural ciliogenesis.
What are the official names of this protein?
DNA-binding protein RFX2, Regulatory factor X 2.
What is the protein family that this protein belongs to?
Belongs to the RFX family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly expressed in the nucleus and at lower level in cytoplasm.
Protein: SEN15_SCHPO
Sequence: MQHNTFLPNDAVEEQKQNPYYGILRAVETDLRLGQRWCELKVHVLDIDLKTKRPLLSGIPVNGQLKDKLQYVLPLYLQETISIEFLSSVFDSMKKLSLPLVKDARGLSGDEFFLYLGIMCSDSTIVYYKITDGLIKPRQNDEE
What is the function of this protein?
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA.  It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini.  There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body (By similarity).
What are the official names of this protein?
Probable tRNA-splicing endonuclease subunit sen15, tRNA-intron endonuclease sen15.
What is the protein family that this protein belongs to?
Belongs to the SEN15 family.
Protein: HISX_BLOPB
Sequence: MISHEHPISIYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQLQIPTEIIMNSGRNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNIVGLYVPGGTAPLLSTVMMLGVPARIAKCKRVILCSPPPIPDVIIYTAQLCGIDEIYQIGGSQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPSEILIIADNTANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSRMIITNNLMECFSISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPNHVLPTYGRAVATSGLGVIDFQKRMSVQQLTQNGLLQLSSTITTLTQIEQLKAHEYAITHRINYIKEQNEHSLLG
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: ACT5C_ANOGA
Sequence: MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
What are the official names of this protein?
Actin-5C, Actin-1D, cytoplasmic.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y347_RICTY
Sequence: MQYLILSLIFLIPSLGMLTGLSIAATVLFFLLIIVITELISFIRKQEFSKKFLIKLYPRFGFDDIFCVKNRIKTELLFIAWCFISCLFTIHPINSLVTFTKVFALLFLRFVNNVVTFQNILYLKNSLILGIITAILLFFIEYSSHGFLTRMFKTHFGLYMLDRGCALLSITTWVVIIILFSNGKNINAFILYIVVLYLLSISDSLASFVGFSIGGIIFILARLIKKIFFKLITISLITGSLLFPIIAKQIDPHNLSEKYLATKPSAAHRLFIWHFVANKIIIKPILGYGFASSKYIKTSDNEMIDYRGEKLHPLPLHPHNNILQITLELGILGLALFLCLVYKYLKEIDNIKISNFRAASYSCFINYYIIGMISYNIWQTWWILSGIWILVLMKLLVKPDIIIDN
What are the official names of this protein?
Putative polysaccharide polymerase RT0347.
What is the protein family that this protein belongs to?
Belongs to the O-antigen polymerase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AROB_ACIBS
Sequence: MQTLHVELGERRYPIFIGSQLDPKQLLEPYIHGQQVMIVSNVTVAPLYLSHYQEALESLGKTVATCILPDGEKYKDIQHLNLIFDALLEAGFNRDCTVLALGGGVIGDMAGFASACFQRGVYFVQVPTTLLSQVDSSVGGKTGINHPLGKNMLGAFQQPQVVLADMAQLNTLPERELSAGLAEVIKYALLGDEDFLVWLEENMDGLVARDADLLAEAVYRSCAHKARIVANDEKEQGERALLNLGHTFGHAIESYLGYGTWLHGEAVATGMVMAADLSQRLGWISNEDVARTKKIIQRANLPISCPQIPLDDFLGHMAHDKKVLNGQLRLVLLKQLGQAVITKDFDVELMKQAILANQHG
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_CAMC1
Sequence: MITVALPKGRIAEDTLEIFRKIFGSSFMFEDRKLILEEGNFRFLMVRNQDIPTYVTEGAADIGVVGLDVLEEHKPNVVRLLDLQIGKCKVCIGIKNEEELDFSRSELKIATKMPNITRNYFAKLAVGVKIIKLYGSIELAPLVGLSDAIVDVVETGSTMKQNGLKVAGDIMQSSAYLIANKNSFIIKKDEILELYQKIKDEISK
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASPH2_MOUSE
Sequence: MWLEWLVAWSWSLDGLRDCIATGIQSVRDCDGTAVITVACLLILFVWYCYHVGREQPRPHVSVNSLLQGVDANGLQNGSMYCQSPECARCTHHEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLSSQPSIQKPEVFFLPDLPTTPYFSRDAQKHDVELLERNFQAILCEFETLYKAFSNCSLPQGWKVNSTPSGEWFTFDFVSQGVCVPRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHYGPTNIRIRCHLGLKTPNGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGSAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR
What is the function of this protein?
May function as 2-oxoglutarate-dependent dioxygenase.
What are the official names of this protein?
Aspartate beta-hydroxylase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: PLSX_GEOTN
Sequence: MNIAIDAMGGDHAPQEIVRGAARAAAHFSDIRITLIGDEAKIRPYLQNEERISIIHADEVIEATDEPVRAVRRKKNSSMVRMAEEVREGRADACISAGNTGALMAAGLFVVGRIAGIDRPALAPTLPTLDGKGFVFLDVGANVDARPEHLQQYALMGHVYAKQVRGIANPRIGLLNVGTEDQKGNETTKRAFALLKETNLHFIGNVEARDLLQGVADVVVADGFSGNVALKTIEGTAMALFSLLKQTLTSSVTAKLAAAALKPKLSGLKKMMDYSEYGGAALFGLNAPVIKAHGSSDANAIFHAVRQAREMVANDVIGTIKAELERTS
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: CACO2_PONAB
Sequence: MEETIEDPPTSAVLLDHCHFSQVIFSSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDQDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDNCVSLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENKIICNALQREKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGAGQNPGLVYGNPYSGIQESSSPSPLSIKKCPICKADDICDHILEQQQMQPLCLNCPICDKIFPATEKQIFEDHVFCHSL
What is the function of this protein?
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity).  Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity).  Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity).  Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity).  May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity).
What are the official names of this protein?
Calcium-binding and coiled-coil domain-containing protein 2, Antigen nuclear dot 52 kDa protein, Nuclear domain 10 protein NDP52, Nuclear domain 10 protein 52, Nuclear dot protein 52.
What is the protein family that this protein belongs to?
Belongs to the CALCOCO family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
Protein: CEP43_MACFA
Sequence: MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEGALDLSDVHPPPKSPEGKTSAQTTPSKKANNEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNKTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRSEPRKQPGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISGKIGSLGLGTGEDDDYVDDFNSTSHRSEKSEISIGEEIEEDLSVEIDDINTSDKLDDLTQDLTVSQLSDVADYLEDVA
What is the function of this protein?
Required for anchoring microtubules to the centrosomes.  Required for ciliation.
What are the official names of this protein?
Centrosomal protein 43, FGFR1 oncogene partner.
What is the protein family that this protein belongs to?
Belongs to the CEP43 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Associated with gamma- tubulin. Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole. Localizes to the distal end of the centriole partly to the subdistal appendage region.
Protein: NUOD_CHLL3
Sequence: MAGQGSVRLTRKSDNVVIIEKDLATEEMVLSMGPQHPSTHGVLRLECRTDGEVVTEAEPYLGYLHRCFEKYCENVDYPAIVPYTDRMDYLAGMNSEMAYAIAVEKLLDIEIPRRVEFIRVIVSELNRIASHLVAIGTYAIDLGAFTPFLFCFRDREHILNMLEWASGARMLYNYIWIGGLAYDVPADFQKRVGEFVDYFRPKALELSRLLTENEIFVKRTKGIGIMPADVAINYGWSGPMLRGSGVQWDLRRNDPYSIYPELDFAVPVPDGKFSDVGDCLSRHLVRALEIEESLKIIEQCIEKMPSAEGFDPRAAVPKRIRPKAGEVYARAENPRGELGFYILSDGKSTSPVRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRR_BACC7
Sequence: MQEKAVVLDDQMIRRALTRISHEIVERNKGVDNCVLVGIKTRGIFIAQRLAERIGQIEGKEMEVGELDITLYRDDLTLQSKNKEPLVKGSDIPVDITKKKVILVDDVLYTGRTVRAAMDALMDLGRPSQIQLAVLVDRGHRELPIRADYVGKNIPTSSEERIEVDLQETDQQDRVSIYDK
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: Y317_CERS1
Sequence: MVEPVQEYRLVLVTGPSGAGRTTAINALEDMGYEVIDNLPLSFVPRLIEGPSIGRPIALGLDVRNRDFNATALIELIDRLTQDPRVALEVLYVDCSASELIRRYNQTRRRHPLAPAETPAEGVEREIDLLAPVRVRADHLIDTSEMSPHDLKAELSRWFDRGAATRLAVSVQSFSYKRGVPRGVDMIFDCRFLKNPYWVESLRTLDGREASVADYISSDPRFGPFFEKLRDLVLFLLPAQLEEGKAHLSLGFGCTGGQHRSVAVAELLGNALAEAGWPVSKRHRELERRAAAVLPTHQGEKA
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Rsph17029_0317.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: CNTP2_MOUSE
Sequence: MVMSLRAGYRAALSLWILSSFICRAWTAPSTFQKCDEPLISGLPHVSFSSSSSLSSSYAPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDSVVRHDLQHAVVARYVRIVPLDWNGEGHIGLRAEVYGCAYWADVINFDGHGVLPYRFRNKKMKTLKDVIALKFKTSESEGVLLHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVTSGSLLDDHHWHSVLIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSNRKNFKGCMESINYNGVNITDLARRKKLGPSNMGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPSGLLLFSHFADNLGNVEIDLVESKVGVHINNTQTKTSQIDISSGSGLNDGQWHEVRFLAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVTIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTTVVGYNPEKYSVTQLIYSASMDQISAITSSAEYCEQYVSYFCRMSRLLNTPDGSPYTWWVGKANEKHYYWGGSEPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLGNTDFIKLELKSATEVSFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFKSGCSGHCTSYGANCENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTGSRAENSADQQQHLAPDLAQEQIHFSFSTTKAPCILLYVSSLTTDFLAVLVKPTGNLQIRYNLGGTREPFNIDVDHRNMANGQPHSVNITRHERTIILKLDHYPAVGYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNHIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEWLI
What is the function of this protein?
Required for gap junction formation (By similarity).  Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons (PubMed:25378149).  Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers.  Demarcates the juxtaparanodal region of the axo-glial junction (Probable) (PubMed:25378149).
What are the official names of this protein?
Contactin-associated protein-like 2, Cell recognition molecule Caspr2.
What is the protein family that this protein belongs to?
Belongs to the neurexin family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cell projection, axon. Cell junction, paranodal septate junction. Note=Expressed in the juxtaparadonal region.
Protein: CRCB1_STAAS
Sequence: MHRQFLSSRCQNLFFKFKLLLFEVNQMQYVYIFIGGALGALLRYLISFLNTDGGFPIGTLIANLTGAFVMGLLTALTIAFFSNHPTLKKAITTGFLGALTTFSTFQLELIHMFDHQQFITLLLYAVTSYVFGILLCYVGIKLGGGLS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLPR2_HUMAN
Sequence: MAGGRPHLKRSFSIIPCFVFVESVLLGIVILLAYRLEFTDTFPVHTQGFFCYDSTYAKPYPGPEAASRVPPALVYALVTAGPTLTILLGELARAFFPAPPSAVPVIGESTIVSGACCRFSPPVRRLVRFLGVYSFGLFTTTIFANAGQVVTGNPTPHFLSVCRPNYTALGCLPPSPDRPGPDRFVTDQGACAGSPSLVAAARRAFPCKDAALCAYAVTYTAMYVTLVFRVKGSRLVKPSLCLALLCPAFLVGVVRVAEYRNHWSDVLAGFLTGAAIATFLVTCVVHNFQSRPPSGRRLSPWEDLGQAPTMDSPLEKNPRSAGRIRHRHGSPHPSRRTAPAVAT
What are the official names of this protein?
Phospholipid phosphatase-related protein type 2, Inactive phospholipid phosphatase PLPPR2, Lipid phosphate phosphatase-related protein type 2, Plasticity-related gene 4 protein, PRG-4.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FEZ1_RAT
Sequence: MEAPLVSLDEEFEDIRPCCTEDPEEKPQSLYGTSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLRDEEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDTEIHEKEEEDEFIEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEVEVLEEEDGGEISSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT
What is the function of this protein?
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery.  May participate in the transport of mitochondria and other cargos along microtubules.
What are the official names of this protein?
Fasciculation and elongation protein zeta-1, Zygin I, Zygin-1.
What is the protein family that this protein belongs to?
Belongs to the zygin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Colocalizes with both, alpha- and gamma-tubulin (By similarity). Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta.