PharMolix/UniProtQA huggingface dataset:
Protein: CAE_XENRU
Sequence: QQDYTGWMDF
What is the function of this protein?
Induces contraction of intestinal smooth muscle in isolated guinea pig ileum.
What are the official names of this protein?
Caerulein.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GEMA_DICDI
Sequence: MKNNIKVILIGDEQVGKSTIINSFISESFSEITQKTLPEVTIPAEFNNEICSTRIIDTFDDGKNLKNQMNMEIRTADAIVIVYSVDRFDTFMSIRMKWIPLINQLRGSNKSPIIIVGNKLDLVDDKHENNKVQIEETIQYFRSTYSNTIQWLECSAKTMENLPELLYASQTSVFFPERILYNREENKMTEGCERALKRIFKLCDHDNDGSLSEEEINYFQTKCGHETMTSEEIQNIQQFVLSKIPDGVNSNGFTEKGFLYMNLLFLLRGPCQHTWTSLRSFNYDDDLVLLESYVHPTLQVPPNHNTILSSMGNEFFKSLFEKYDSDSDGVLSSFDLVSLFSTTPKIPWEIGFEKHFNTDKDSNLTLSGFLSLWNLQTYENYKVTLEYLAYFGSQTENNNIDMISILNSRELDIKSNQFTRNIVNCYVFGAEAVGKTTFLNTFIGKSFSTLYNATNGNDNFKVCGHLLKNKYLILSEYVGEKIPTAELKSKCDLVCLLYDCNSEQSFKFIENIYNQLKQQQLNIPIVFIRTKNNNNNNNNNNNNNNNNNNNNLNNNNNNINNNNNNNNNNTTTTNANVSTSKIIDSFFKSHKNYSPKDFSISRSNSIYHEMMETIVNSSFNDNSNGSNGSNNSNILTYLVIAAGVAGVGLLLSKYLAKK
What is the function of this protein?
Mitochondrial GTPase involved in mitochondrial trafficking.  Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
What are the official names of this protein?
Probable mitochondrial Rho GTPase gemA, Miro.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial Rho GTPase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein.
Protein: RL35_LACPL
Sequence: MPKQKTNRAAAKRFKVTAKGKIKSANAFTSHRFHGKTKKQRRQLRGTAIIEKPMVKTYHKLLQK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RL19_STAAB
Sequence: MTNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKRRGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYLRSLRGKAARIQEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MIAA_SHEAM
Sequence: MTSLPKVLFLMGPTASGKTALALDMAEHHNCEIISVDSALIYRGMDIGTAKPTASELARAPHKLIDILDPLESYSAADFRADAVREIEETLSRGKTPLLVGGTMMYFKTLLDGLSPLPSADDAVRAQIAAEVEARGWQALHDELRNIDPVSAERIHPNDPQRLSRAIEVYRISGKTLTELTKIKAESLPYHMVQFAIAPQDRTVLHGLIAKRFQQMLAEGFIGEVETLKARGDLHLELPSMRCVGYRQAWQYLDGEFDHATMVEKAVAATRQLAKRQLTWLRGWPELHWLASGDEGNLDKLVQQSR
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: SFGH1_ECOL6
Sequence: MELIEKHASFGGWQNVYRHYSQSLKCEMNVGVYLPPKAENEKLPVLYWLSGLTCNEQNFITKSGMQRYAAEHNIIVVAPDTSPRGSHVADADRYDLGQGAGFYLNATQAPWNEHYKMYDYIRNELPNLVMHHFPATARKSISGHSMGGLGALVLALRNPDEYASVSAFSPIVSPSQVPWGQQAFAAYLGENKDAWLDYDPVSLISQGQRVAEIMVDQGLSDDFYAEQLRTSNLEKICQEMNIKTLIRYHEGYDHSYYFVSSFIGEHIAYHANKLNMR
What is the function of this protein?
Serine hydrolase involved in the detoxification of formaldehyde.  Hydrolyzes S-formylglutathione to glutathione and formate (By similarity).
What are the official names of this protein?
S-formylglutathione hydrolase FrmB, FGH.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
Protein: SYP_KOCRD
Sequence: MPLRLSSLFLRTLREDPVDADVDSHKLLVRAGYIRRAAPGIYTWLPLGLAVLRRVEGIVREEMDAIGAQEVHFPALLPREPYEASNRWTEYGENLFRLQDRKGADYLLAPTHEEMFTLLVKDMYSSYKDLPVMLYQIQTKYRDEARPRAGLLRGREFIMKDSYSFDVDDAGLDDAYAKHRAAYVRIFERLGLPVVAVSATSGAMGGSRSEEFMHPSVVGEDTFVRSAGGYAANVEAVTTVVPEPVDCTDAPAAQVHRTPDSPTIDTLVSRSNELHPREGQPWTAADTLKNVLLSVSLPEGGTQLVAVGVPGDREIDLKRVEAGIGGALGIGGELEVEAASEEQLRAVPELVKGYIGPGLSREDALLGTESPTGIPYFVDPRVVPGTRWITGANVAEAHVYDLVAERDFTWDATLEACTVREGDPAPDGSGPLEIARGMEMGHVFQLGRKYAEALGLKVLDNNGKLVTVTMGSYGIGVTRALAAVAEFYHDEHGLLWPRNLSPADVHVVATGKGPEVLEAAEEIVAHLEAAGVSVLFDDRPKVSPGVKFRDAELLGVPTVLVVGRGLADGVLELKDRRSGTSRDIARDRVVAEITAELQGQEGPAAE
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCUB_SHIFL
Sequence: MLFTIQLIIILICLFYGARKGGIALGLLGGIGLVILVFVFHLQPGKPPVDVMLVIIAVVAASATLQASGGLDVMLQIAEKLLRRNPKYVSIVAPFVTCTLTILCGTGHVVYTILPIIYDVAIKNNIRPERPMAASSIGAQMGIIASPVSVAVVSLVAMLGNVTFDGRHLEFLDLLAITIPSTLIGILAIGIFSWFRGKDLDKDEEFQKFISVPENREYVYGDTATLLDKKLPKSNWLAMWIFLGAIAVVALLGADSDLRPSFGGKPLSMVLVIQMFMLLTGALIIILTKTNPASISKNEVFRSGMIAIVAVYGIAWMAETMFGAHMSEIQGVLGEMVKEYPWAYAIVLLLVSKFVNSQAAALAAIVPVALAIGVDPAYIVASAPACYGYYILPTYPSDLAAIQFDRSGTTHIGRFVINHSFILPGLIGVSVSCVFGWIFAAMYGFL
What is the function of this protein?
In addition, possesses a regulatory function, which is independent from the transport function, and is required for the response of the DcuS/DcuR two-component system to C4-dicarboxylates (By similarity).  DcuB interacts physically with DcuS and converts DcuS to the C4-dicarboxylate responsive form (By similarity).
What are the official names of this protein?
Anaerobic C4-dicarboxylate transporter DcuB.
What is the protein family that this protein belongs to?
Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MRAY_LACLS
Sequence: MLLNGIVAAVITMIITIIGIPRFIMFFHKKKLGGQPTLEDVKQHASKAGTPTMGGFVFVVVSLVVSLVAALVFGKFSPAFITAWWVFAMYAVIGFLDDFLKVFKQINEGLTAKQKMLAQILIGIVSYFIYSHGEKSHIIHILSWQVNIGIFFSIFIIIWLVGWSNAVNLTDGIDGLASITVAISLTAYAVIAVVHQQYDVLLIILSVIGGLLGFFVFNHKPAKIFMGDVGSLALGGFLAIVSILLHAEWTLLLIGAVYVIETLSVMLQVAYFKKTGGKRIFRMTPIHHHFELGGFSGKAVGWSEWKIDIVFWLFTAVLSVIALCIYFAF
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS19_BURP1
Sequence: MARSVKKGPFCDAHLLKKVEAAAASRDKKPIKTWSRRSTILPDFIGLTIAVHNGRQHVPVYISENMVGHKLGEFALTRTFKGHAADKKAKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: EFP_SHEB8
Sequence: MKTAHEIRPGNVIMLDGSPWVVQKTETTRSGRNAAIVKLKLKNLLLNSGTETTFKGEDKLEDIILDRLDCTYSYFADPMFVFMDAEYNQYDVEAENLGDAAAYIVDGMEETCQVTFYDGKAISVEMPTTIVREVIYTEPSARGDTSGKVMKPATITGGGTVTVADFVKVGDKIEIDTRTGEFKKRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURR_SALA4
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLSMLEEYRHIPMVVMDWGEAKADFTDTVIDNAFAGGYMAGRYLVERGHRDIGVIPGPLERNTGAGRLAGFMKAMEEALINVPDNWIVQGDFEPESGYHAMQQILSQSHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSVIGYDNVRNARFFTPALTTIHQPKDSLGETAFNMLLDRIVNKREESQSIEVHPRLVERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: NUOB_BUCA5
Sequence: MNYTLTKADSDNNNKKYPKQTIESVSDPLEEYLKKNIFMGKITQLLHKLVNWGRKNSLWPYNFGLSCCYVEMVSAFTSVHDVARFGSEVLRASPRQADVMVIAGTPFIKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFLPVDIYIPGCPPRPEAYMQALILLQKLINEERRPLSWVIGEQGVYHKKMPSERVQKRSKRINIINLSTSEKI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CCSE2_HUMAN
Sequence: MEEKTQIKTFLGSKLPKYGTKSVRSTLQPMPNGTPVNLLGTSKNSNVKSYIKNNGSDCPSSHSFNWRKANKYQLCAQGVEEPNNTQNSHDKIIDPEKRVPTQGMFDKNGIKGGLKSVSLFTSKLAKPSTMFVSSTEELNQKSFSGPSNLGKFTKGTLLGRTSYSSINTPKSQLNGFYGNRSAGSMQRPRANSCATRSSSGESLAQSPDSSKSINCEKMVRSQSFSHSIQNSFLPPSSITRSHSFNRAVDLTKPYQNQQLSIRVPLRSSMLTRNSRQPEVLNGNEHLGYGFNRPYAAGGKKLALPNGPGVTSTLGYRMVHPSLLKSSRSPFSGTMTVDGNKNSPADTCVEEDATVLAKDRAANKDQELIENESYRTKNNQTMKHDAKMRYLSDDVDDISLSSLSSSDKNDLSEDFSDDFIDIEDSNRTRITPEEMSLKEEKHENGPPQDMFDSPKENEKAFSKTDEWIDISVSDRSECTKHTSGNNLVSPDTDYRAGSSFELSPSDSSDGTYMWDEEGLEPIGNVHPVGSYESSEMNSIDILNNLESCDLEDDDLMLDVDLPEDAPLENVECDNMNRFDRPDRNVRQPQEGFWKRPPQRWSGQEHYHLSHPDHYHHHGKSDLSRGSPYRESPLGHFESYGGMPFFQAQKMFVDVPENTVILDEMTLRHMVQDCTAVKTQLLKLKRLLHQHDGSGSLHDIQLSLPSSPEPEDGDKVYKNEDLLNEIKQLKDEIKKKDEKIQLLELQLATQHICHQKCKEEKCTYADKYTQTPWRRIPGGYSAPSFSPWQGSFQGIPRTVPPHRRQTSSTTAFQQPSQTHRSHPGKTNKATTYRGPQ
What is the function of this protein?
Microtubule-binding protein which might play a role in microtubule bundling.
What are the official names of this protein?
Serine-rich coiled-coil domain-containing protein 2, Coiled-coil serine-rich protein 2, Protein GCAP14 homolog.
What is the protein family that this protein belongs to?
Belongs to the CCSER family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associates with microtubules in interphase. Has diffuse expression throughout the cell during mitosis.
Protein: BIOD_CAUVC
Sequence: MKSLFVAGTGTDLGKTHVACALLEAARAGGLSVDAFKPVVSGFDPDAPDDSDPARLARALGRPEAWTDVSPRRYRAPLAPNIAARLEGDTLQMDDLITDCREWLIGRDVGLALIEGAGGVMSPMTDEATNLDLMVALGLPVLLVAGSYLGTASHLLTALEVLRARGLSIAAIVVSESLDAPDLDQTLGLLRAFEHQATILSAPRAGNWDAGSLVDLLMA
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGA3_HUMAN
Sequence: MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL
What is the function of this protein?
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes.  Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005).  Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329).  nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:17553422, PubMed:15615712, PubMed:20484053).  Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712).  Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053).  Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-binding protein GGA3, Golgi-localized, gamma ear-containing, ARF-binding protein 3.
What is the protein family that this protein belongs to?
Belongs to the GGA protein family.
Protein: AROQ_HELPG
Sequence: MKILVIQGPNLNMLGHRDPRLYGMVTLDQIHEIMQTFVKQGNLDVELEFFQTNFEGEIIDKIQESVGSDYEGIIINPGAFSHTSIAIADAIMLAGKPVIEVHLTNIQAREEFRKNSYTGAACGGVIMGFGPLGYNMALMAMVNILAEMKAFQEAQKNNPNNPINNQK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RL20_LACPL
Sequence: MARVKGGTVTRKRRKRILKLAKGYRGAKHIQFKVAKDQVMKSYLYAFRDRRRRKSDFRRLWIARINAAARINDISYSQLMHGLKLANVDVNRKMLADLAVNDADAFKALVDTAKKALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NTE1_ENCCU
Sequence: MVSLSLLIAIIVVTGLLAGFRHYGSSRCRTVPFKIKSRSIEKTASTRLLGMSLEDAMKRYPLFNFYPGQSIREILSSWERVTYGNGETIAAPGFILQGLVEIWYREHLVCVKEKGSFLNGSMELLGYSTRGTKKARGSVEVLLIDASLVRDNIWYILFSMLRKSCIEIACRYFELESKLVEKETMKIKDDGQGHLDLFLSFLNEKLLLNLDDGKEILRRDIEARLIGRGETIKDSEESMDYIMYVVSGEILVLAGESAFVFGKGSVFGYFSLFFDLYSSIKIQAREDSSVLLCSSSVLLKFGLDEKKFDHSMLLDIDESLHIIDESAEWMRLLPGDMIAQKGDASKEIFYIGAGSVKSASRESSSGTVIGGKECIFGESWNESSIATRITDVVRIPSLLVDYFLERDKSFFKKYTKRLFESGNKANGKIVSIIPVGQYKDIESFSRKLKSAIGASSLLLSRRDVVEILARRAFDTTEEVRFMDYLTKMSRRYEIILIYVENEYSRLLRYLLNFSDVLLAVGTTFADIPEYNVYCRIEFVKIYEERRASDERSVKKSKKINHGPRYLESRKESFGQYDRVHHVLFPSKTMLFCSKDFQRLARSLLGKRIGLVLGGGGARGLAHIGVIQALEEEGIPIDCVGGTSMGAFIGALYAKECNNYHVFKQAKRFSRKMSNIWILLLDLTYPICSMFSGHAFNRSLHSIFGDGLIQDLWLEYFCITTNIVSYEEEVHRNGMVWRYVRASMGLCGYLPPICDNKKLLVDGGYLNNVPADVMMGMQVEKIITVDVGTVLENDHFDYGDTLSGFTILFNKFFGNKKFVTMEEIQYRLAYISTERKMKELEANGNIIMLRPDLGKYRTMDFKKFDEIVACGYQSTKNAIAKWKQEGTYDVLFFSLKKQTPKRRYSV
What is the function of this protein?
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho).  Plays an important role in membrane lipid homeostasis.  Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
What are the official names of this protein?
Lysophospholipase NTE1, Intracellular phospholipase B, Neuropathy target esterase homolog.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: IHFB_KLEP7
Sequence: MTKSELIERLASQQSHIPAKAVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYEG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PELS1_YEAST
Sequence: MTAKTKQSWNKGIWENGKQGSHQQTFLPKIWVNIYSTPTS
What is the function of this protein?
Modulates the lysine biosynthesis pathway, possibly by stabilizing the lysine biosynthesis LYS1 protein in lysine-deplete conditions.
What are the official names of this protein?
Peroxisomal LYS1 stabilizing protein 1.
Protein: Y514_MYCPN
Sequence: MEQDINNQTGKKIFLNEECFLELDKLPQHVSVLGVSGFGKSNILLHFLKYAIDNDHPLIFVNGKGDKELITQFEHYQTSAKQLSPEDGFDTVKLVALKNTSAKIWSLDDRIATIKYNPFK
What are the official names of this protein?
Uncharacterized protein MPN_514.
Protein: YR869_MIMIV
Sequence: MSLKLYFKITNELECHRGFQYKDGLNILKGEFNGDPKDFCVPGRLYFCEPKDIHHYLHFGIHLREVYLPIDNPDFKMVINRLKIYGANMIILGKKYYLKDLDTWKYMIECGLDIHLNENEPLKCAISNGYLEIVGKLL
What are the official names of this protein?
Uncharacterized protein R869.
Protein: NSP2_ROTGA
Sequence: MTQSVSLSDFIVKTEDGYMPSDRECIALDRYLSKEQKELRETFKDGKNDRAALRIKMFLCPSPSRRFTQHGVVPMREIKTNTDMPSTLWTLVTDWLLNLLQDEENQEMFEDFISSKFPDVLASADKLARFAQRLEDRKDVLRKNFGKAMNAFGACFWAIKPTFATEGKCNVVRASDDSIILEFQPVPEYFRCGKSKATFYKLYPLSDEQPVNGMLALKAVAGNQFFMYHGHGHIRTVPYHELLTLSNHSLVKIKKRSKTFLNHHSQLNVVVNFSICSME
What is the function of this protein?
Participates in replication and packaging of the viral genome.  Plays a crucial role, together with NSP5, in the formation of virus factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Displays ssRNA binding, NTPase, RNA triphosphatase (RTPase) and ATP-independent helix-unwinding activities.  The unwinding activity may prepare and organize plus-strand RNAs for packaging and replication by removing interfering secondary structures.  The RTPase activity plays a role in the removal of the gamma-phosphate from the rotavirus RNA minus strands of dsRNA genome segments.
What are the official names of this protein?
Non-structural protein 2, NSP2, NCVP3, Non-structural RNA-binding protein 35, NS35.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP2 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called viral factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RS3_ACIB5
Sequence: MGQKVHPIGIRLGVVKRHNANWYANPKQYAEYLLKDLQVREFLTKNLKNAMVSNILIERPSGAAKVTISTARPGIVIGKKGEDIEKLQRELTNIMGVPAQVSINEIDRPDLDARLVAEAIASQLEKRVMFRRAMKRAVQNTMRAGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYATMRAETTYGTIGVKVWIFRGEILGGMKQVMNPAPAEERPAKRGRGRGEGQERRGRRGDRAADKGE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RIFK_PICTO
Sequence: MENIYIALKTIKKMAGEKNTVFISSKELANEMNVSQQTASRIIISLDRLGYITRTLENRKQKITINDSGLDVLYREYNEISSILRFSQELKLVGAVQDGLGEGKYYISKKGYKDQFIAKLGIDPYPGTLNIKILNEYENNLRRIKNSDGIYITGFKDQQRTFGGVFCHAARIDGIRCFIIFPERSVYRDTFEVISEKYLRKELNLENGAIIEVLASIDGKL
What is the function of this protein?
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
What are the official names of this protein?
Riboflavin kinase, RFK, CTP-dependent riboflavin kinase, CTP:riboflavin 5'-phosphotransferase, Flavokinase.
What is the protein family that this protein belongs to?
Belongs to the archaeal riboflavin kinase family.
Protein: RRF_SALG2
Sequence: MISDIRKDAEVRMEKCVEAFKTQISKVRTGRASPSLLDGIVVEYYGTPTPLRQLASVTVEDSRTLKINVFDRSMGPAVEKAIMASDLGLNPSSAGTDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKAISEDDDRRSQEEVQKMTDAAIKKVDAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIO_CAMDR
Sequence: MVKSHMGSWILVLFVVTWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGAHGQWNKPSKPKTSMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYKPVDQYSNQNSFVHDCVNITVKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYQREYQASYGRGASVIFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.