PharMolix/UniProtQA huggingface dataset:
Protein: K1C25_PANTR
Sequence: MSLRLSSASRRSCPRPTTGSLRLSGGGTSFGTGNSCGISGIGSGFSCAFGGSSLGGNTAGGNPCAGFTVNERGLLSGNEKVTMQNLNDRLASYLDSVHALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDDLKNQIIASTTSNANAVLQIDNARLTADDFRLKYENELALHQSVEADVNGLRRVLDEITLCRTDLEIQYETLSEEMTYLKKNHKEEMQVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISEDVGATTSARNELTEMKRTLQTLEIELQSLLATKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKLHLEKEIETYCLLIGGDDGACKSGGYKSKDYGSGNVGSQVKDSAKAIVVKKVLEEVDQRSKILTTRLRSLEEKSQSN
What is the function of this protein?
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity).  Plays a role in the cytoskeleton organization (By similarity).
What are the official names of this protein?
Keratin, type I cytoskeletal 25, Cytokeratin-25, CK-25, Keratin-25, K25, Keratin-25A, K25A, Type I inner root sheath-specific keratin-K25irs1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCL1_HUMAN
Sequence: MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPIQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPGFGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).  Does not have cyclase activity (By similarity).
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase-like protein.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: C734A_ARATH
Sequence: MEEESSSWFIPKVLVLSVILSLVIVKGMSLLWWRPRKIEEHFSKQGIRGPPYHFFIGNVKELVGMMLKASSHPMPFSHNILPRVLSFYHHWRKIYGATFLVWFGPTFRLTVADPDLIREIFSKSEFYEKNEAHPLVKQLEGDGLLSLKGEKWAHHRKIISPTFHMENLKLLVPVVLKSVTDMVDKWSDKLSENGEVEVDVYEWFQILTEDVISRTAFGSSYEDGRAVFRLQAQQMLLCAEAFQKVFIPGYRFFPTRGNLKSWKLDKEIRKSLLKLIERRRQNAIDGEGEECKEPAAKDLLGLMIQAKNVTVQDIVEECKSFFFAGKQTTSNLLTWTTILLSMHPEWQAKARDEVLRVCGSRDVPTKDHVVKLKTLSMILNESLRLYPPIVATIRRAKSDVKLGGYKIPCGTELLIPIIAVHHDQAIWGNDVNEFNPARFADGVPRAAKHPVGFIPFGLGVRTCIGQNLAILQAKLTLAVMIQRFTFHLAPTYQHAPTVLMLLYPQHGAPITFRRLTNHED
What is the function of this protein?
Cytochrome P450 involved in brassinosteroids (BRs) inactivation and regulation of BRs homeostasis.  Inactivates the BRs castasterone (CS) and brassinolide (BL) through carbon 26 hydroxylation.  Acts in association with CYP72C1 to inactivate BRs and modulate photomorphogenesis.
What are the official names of this protein?
Cytochrome P450 734A1, Protein PHYB ACTIVATION-TAGGED SUPPRESSOR 1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS13_NEIMF
Sequence: MARIAGVNIPNNAHIVIGLQAIYGIGATRAKLICEAANIAPDTKAKDLDETQLDALRDQVAKYEVEGDLRREVTMSIKRLMDMGCYRGFRHRRGLPCRGQRTRTNARTRKGPRKAIAGKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RL4_XANCP
Sequence: MELVITGSNNKVSVSDAVFGREFSEDLVHQVVVAYRNAGRAGTKAQKTRSEVAGTTKKSKKQKGGGARHGALTAPIFVGGGVTFAAKPRSFEQKVNRKMYRAAICAIFSELNRQGRLMIVDSFDIEATKTKGLIEKLKGMDVGKRPLIVTEEASEHLYLSARNLPYVQVRDVQGLDPVALVGADTVVITADAVKKVEEWLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RLMM_XANCP
Sequence: MSGLLCYCRQGFEPELAAELSARAAFVGIAGYARTQRNDGYVLFVCDEAAQLAARLQWRELIFARQKLVVLAELKGLDPKDRITPILAALDGQPRFGDLWVEHPDSDAGKPLAGLARSFGNALRPALRKAGLLTDKPQARLPRLHICFLDGDHALLAVADSSDSAPWPLGIPRLKLLPEAPSRSALKLDEALLTLLTPEEREQLVKPGMRAADLGAAPGGWTWVLTRQHVHVTSVDNGPLREHVLATGLVEHLRADGFHWKPAQPLDWMVCDMVEQPRRVAERMATWVREGWCRHTIFNLKLPMKKRWDETRLCLDLFEQQAEKSLTVRAKQLYHDREEITVLAMRG
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_CERS4
Sequence: MTSSDPTLRPERLPEDMDRALRPQSLEEFVGQAEARANLRVFIESARMRGEAMDHTLFHGPPGLGKTTLAQIMARELGVGFRMTSGPVLAKPGDLAAILTNLEPRDVLFIDEIHRLSPVVEEVLYPALEDFALDLVIGEGPAARTVRIDLQPFTLVGATTRLGLLTTPLRDRFGIPTRLQFYTEDELDLIVARGARMMGVDSDPEGTREIARRARGTPRIAGRLLRRVVDFALVEGDGRLTQAIADRALTRLGVDHLGLDLGDRRYIGLIAENYGGGPVGIETIAAALSESRDAVEEVIEPYLLQQGLIQRTPRGRMLAHKAWRHMGIEPPKGPGQSDLFG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MURC_METNO
Sequence: MKLPNKLGPIHFIGIGGIGMSGIAEVMHNLGYTVQGSDAADNYNVRRLAEKGIRTFVGHRGENLADAELVVVSTAIRRDNPELALARERRLPVVRRAEMLAELMRFKSCVAVAGTHGKTTTTSLVATLLDAGGLDPTVINGGIINAYGTNARMGEGDWMVVEADESDGTFLKLPADIAIVTNIDPEHLDHFGSFDAIKDAFRAFIDNIPFYGFAVMCIDHPTVQDLVGRIEDRRIVTYGENPQADVRLIDVDLKGGQSRFRVMIRDRRPGFRLEMEDLVLPMPGKHNALNATAALAVAHELGVSPEAIRRALAGFGGVKRRFTRTGEWNGAQIFDDYGHHPVEIKAVLKAARASTEGRVVAVVQPHRYTRLASLFDDFCTCFNDADTVIVAPVYAAGEAPIEGFDRDALVAGLKSRGHRNAVALERSEDLAAMISGLAGPGDYVVCLGAGNITQWAYALPGELAALGEKAA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_RHOTS
Sequence: MEEFKRNLELDRSQQHDFIYPLIFQEYIYALAHDRGLNRSIFLEDTGYDNKSSLLIVKRLITHLITQMYQQNHFLFSGNDSNQNKFLGYNTNFYSQMIFEGFAVVVEIPFYLRLLSFLEGKERVKSHNLRSIHSIFPFLEDKFSHLVYVLDILISHPIHLEILVQTLRYWVKDASSLHLLRFFLHEYPIWNSLITPKKSSFSFSIRNQRFFLFLYNFNVWEYESIFVFLRNQSSHLRSISSETFLERISFYRKIELEVFTKDFKAILWVFKEPFLHYVRYRGKAILASKGTFLLMNKWKYYLVNFWQCYFYMWSQPRRININQLSNHSLDFLGYLSTVRLKPLMVRSQMIENSFLIENASKKFDTLMPITPMIGSLSKAKFCNVLGHPMSKPVWAALSDSDIIERFGRIYRNLSHYYSGSLKKMSLYRIKYILRLSCARTLARKHKSTVRAFLKRLGVGLLEEFFTEEEQVFYLTFAKASSNSGELYRRRVWYLDIICINDLANYE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ENGB_COLP3
Sequence: MSSTKIHLTKAAFTISAPDIRRLPADSGIEVAFAGRSNAGKSSALNTLTNQRGLARISKTPGRTQLINVFEVAENRRLIDLPGYGFAQVPLAMKKKWQKALGEYLEKRQCLKGLVVLMDIRHPLKDLDMDLIQWAADSDLPVLALLTKCDKLSQGKRSSEVLAVKKALSSLNADIQVQAFSSLKYTGKEQADAIICQWLEQEAQEYELPEEDDFDDSDEFTEEE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: NUDC1_XENTR
Sequence: MEGSNCSLRVNRQLLDPKFESYKLSLDPLPCYNVELDAAVAEVCLRDDQYTLDHMRAFGMYNYLHCNPWIPNSVFYVDQLERVMSFTVTLDTAMGKPIEVFRFPRDLNTCDSRLCSSMYFASAQWVTLSDGTGTLYIIRIGNQSGSVSGKWEIMFNQELGEPFIVVHSVSSVRDELHIIDVLLLSIEKDESDIKGSGFHVCLEWVSIARAQNEDNGKYEILKRRKLFGKSVPHYAAIEPLGNGVMMISYKPFRFIANDKDQPESSEDEKMDEDNKREPLYNWHQTGEDVTLTFQLPEGMTKEDLTIKFLPGEIDISLKDQGTFLKGQLYLDIDCESSAWIIKEGRSVEVTLTKREPGSTWAELVIGDKHGEYIVDPTQTAAIAEQLMHLTSEDMNPNPETEKPPCNAQELEECDLFLEDSTSLCRFDGARLKATHVVNLGSNPYLFTFVATPELMPCFALRHDVDALLWQPVSEQADNLWDHIATFNALGYVQASKQDKKFFTCAPNFSYSALCECVRRIFIYRQPTPVSTELYNRKEGRRVGQVAKQQVASLETTDPIVGFQASNERLFVLTTKKLSVIKVNSTD
What are the official names of this protein?
NudC domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MEND_CORJK
Sequence: MRAGLVLVDQLIRSGVREAVLCPGSRNSPLNLAFVEAERVGRVRLHVRTDERSAAFLALGLAKVSRRPVPVVMTSGTAVANCLPAMVEATLSGVPLVVLSANRPLSMLGSGANQTIDQAEIFGTHSVCTLNTGELALEGAAAGAAGELRDLVRKLINAATDPIDGGGAHLDVPLREPLVPPTLDELSLWAGEIAAAEDAATTEGAHDSHAPSQPTRGPRKLPYGQVEVDLSRRTLVIAGSVSDVAWARSIMDELADVPTVAEPVAPAPDFPVHSAAVDMFSTQVVSDGEHSAVTIPEQIVVIGRPTLHRGVTKLLANKDINVIALSDTRNVTDVFDNVDEVGSTVRPRGEQPESWLQVARAISDMGVNQVRDGLAEREPFTAVHAVAVVADALRDGDLLVLGASTAVRDASRAGLPFDGVQAIANRGAAGIDGTISTAVGAAMAHAHADPTAIRAPRTIAVMGDLTFAHDLGGLNIGPLEPRPDNLLIVLTNDSGGGIFETLEPGAENLRTFADGTAAFERVFGTPLDLDFAELCAGFGVEHKLATSVEELATVIDEHAEIGGSGITVLEVKVSRRGRQEIEKRIAGTR
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: ILVC_LEPBA
Sequence: MANIYYDDSCDLNLLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLRDGSKSVKEAKEAGFEVYNVAEASKKADIIQILAPDTIQADMYKADIEPNLSEGKALVFSHGFNIHYDLITPPKNVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDATGQAKARALAHASGVGGGRAGILETSFREETETDLFGEQAVLCGGVANLIMSGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGDYISGPRVIDAGVKARMKDVLTDIQKDKGAAFAKRWMADTKAGYPEYKKLKEKNAAHPIEAVGTKLRSMMKWLAK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SPRT_ECOBW
Sequence: MKTSRLPIAIQQAVMRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMENVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAVYRCVHCGEQLVAK
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_ECOSE
Sequence: MIEADRLISAGTTLPEDVADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATTRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: BAMC_KANKD
Sequence: MSTLNKYKTLIIISSLAAVSSCSWFSAKDGTEDIDDRYMKSQQDLELQVPPNVKQIEVQDRYRVPEGVIITNRNAKGKALSLDPPQLLLVGGDGVREDSEQSHPTVWVRHQDTPFMNYVSRFMMQKNIPVISSTEKQISSDWISDEDEDIFSQYIGSYNLDGQRHKVTLEIIGQNANEVAVQARNTQSQRLVDDKWVTMNTSKTVASQFLNAFLGFYDTERTKEARERILEEGTINVSLGTNSQGQIALIAERDLIAIWEHLPSVLEDLNLSVSDRDQSAGIYYFNVKEPETGFWAWLWGNDETNAKVDMEPGDYQIHLAATTYGVSMTFKDEEGNLLDSNLVTKIYPEFAASFKSRGK
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamC.
What is the protein family that this protein belongs to?
Belongs to the BamC family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: PA2B1_LACMU
Sequence: HLLKFNKMIKFETRKNAIPFYAFYGCYCGWGGRXXXXXXXXXCCFVHDCCYGKXXXXXXXWDLYRYSLKSGYLTCGKGTWCEEQICECDRVAAECLRRSLSTYKYGYMFYPDSRCRGPSETC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that displays neurotoxic and myotoxic activities.  Induces inflammatory edema by mechanisms involving mast cell activation and arachidonic acid metabolites.  Increases plasma creatine kinase activity.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 LmTX-I, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PNP_BORRA
Sequence: MRKILKLKIGREDLILETGLLAKQANGAVLATYGGSTVLATVCCSDSIRENLDFVPLSVEYNEKYYAAGKIPGGFIKREGKPKDKEVLVSRLIDRPMRPLFDKRFGREIQVVPTTLSTDQMNPPDIVGMNAAFTAVFLSDIPFNGPIAAVRIAYLNDEFIVNPSFDEIQDSVLDIVVAGSLDGITMVEGGANEVSEEILLDAIDKAYTYIKQICDLQKEFIYLIGEREKLPLAYEEKVFEFKDDLRSLIYFELKDACFVRGKLNRDKAIKLVKQKAYEHFSSLEQLNDENEILFYKACDDFEQEIVRKSILEDNLRTDGRTPTQIRDIIAEVDLLKRTHGSALFTRGETQALAVTTLGTSIDEQVMDDIDGDKRLNFMLHYNFPPFSVGETGRLMTGRREIGHGHLAQRSLEAMLPKKDDFPYTIRVVSEVLESNGSSSMATVCSGSMSLMAAGVPVKEQVAGIAMGLISNDDKYVILSDILGEEDHLGDMDFKVAGTKNGITGFQMDIKISNVTKQLMRDALEQARIGRMHILSIMDSVISSSRGDISVNAPKIVQLQIDIDKISLVIGSTGKTVKAITDEFEVRVQIEQDGRITLFGTDNLKMQKAKAKIESIVREPKVGEIYDGIVKKINSFGAFIELTPTKEGFLSNRSRSRDDRYGSDIRHSRYSNRHSRYGRDNRSSFSMRFPRLEEGQIVKVRISDIDKFGKIELELARD
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2147_LISMO
Sequence: MSQILFKTKTFWYGIALTFCIATLSYFLAKLPFLMILGQLVTAILIGIIIRALFPVPDKWFTGIQFSNKVILRAGIILLGFRLNLVDIYHAGWRVFLIAALCLSFGITIVYFLAKLFGVDKKLAILVACGTGICGAAAVVAISPQVKADNNQTAVAATIIALLGTIFTVIYTLIYPILPLGPDGYGIFAGATLHEIAHVIAAADPGGSSAVDMAVIVKLTRVALLVPVCFVVAKMVNAGTKNRFSWAELPVPWFIFGFLATSAINSFGIIPTSVTDFLVICAYFLIAMSMGGLGLNVHLPSFGKMGGKPFAAALIGSVFLSVFGLALVLLFHLAG
What are the official names of this protein?
UPF0324 membrane protein lmo2147.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RT03_PETHY
Sequence: MARKGNPISVRLDLNRSSDSSWFSYYYGKSVYQDVNLRSYFGSIRPPTRLTFGFRLGRCIILHFPKRTFIHFFLPRRPRRLKRREKSRPVKEKGRWGAFGKVGPIGCLHSSDGTEEERNEVRGRGAGKRVESIRLDDREKQNEIRIWPKKKQGYGYHDRSPSIKKNLSKSLRVSGAFKHPKYAGIENDIAFLIENDDSFRKTNLFKFFFPKKSRSDRPTSHLLKRTLPAVRPSLNYSVMQYLLNTKNKIHFDPVVVLNHFVAPGVAEPSTMGGANAQGRSLDKRIASCIAFFVENSTSEKKCLAEAKKRVTHFIRQANDLRFAGTTKTTISLFPFFGATFFFPRDGVGVYNNLFFEDAREQLLGQLRRKCWNLMGKDKVMELIEKFIDLNRIGELIRGIEMMIEIILRNRRIPYGYNYYLNEVKKMRSLLYNRTNTNTLIESVKIKSVYQSASPIAQDISFQPRNKTRSFRSIFSKIVKDIPLVMKKGVEGIRICCSGRLEGAEIARTECGKYGKTSRNVFNQKIDYAPAEVSTRYGISGVKVWISYSKKKKGRAISETYEI
What are the official names of this protein?
Ribosomal protein S3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: BEA2_GIBF5
Sequence: MASQEHPNWLTALLADTRPPPKLFAWSPANIQPKLDEGIDMGSSNSDEEYDNDACVCPSTDSDQRIYIIGPGNIGRLYATHMARHPNALPITLVVHRKELLSQWAACEGVGLADLTSGKIFLNKRFTVEWWTETRPPYGPVKEVADGKKLHNVFISTKAEAGLSEADRIRRYLGRCSSVVFAQNGVCKLWPPHGPLYISHRYPSGDTPTFSACVVSHGVASAGPFLSVHAAPADAYIGPVFWASDPESPWRQPSDDFFIRHIATTPLVNTKQVSSGEIWLLQLEKLVMNAAINPLTALLRYKTGELFTSYGSDDPLARVIDKLLWQTSAVIQGLIDHETSHSVITSYAEQMSQPGTSCSVPKVRKKLTERFSQPILKAKLYAFGLKIFEHRSSMLQDIEAGRKTEIRDFNGWIVDTACFLGTGLDVSVHSGLTGLIERCERFDKMELGRALL
What is the function of this protein?
Ketoisovalerate reductase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:27750383).  Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (By similarity).  The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclization of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine (By similarity).
What are the official names of this protein?
Ketoisovalerate reductase BEA2, KIVR, Beauvericin biosynthesis cluster protein 2.
What is the protein family that this protein belongs to?
Belongs to the ketopantoate reductase family.
Protein: LPXB_PARXL
Sequence: MALQPSPLRVAMVAGEPSGDLLAASLLDGLASRLPAGTQYYGIGGPRMIATGFDAHFPMEKLTVRGYVEALKHIPEILGIRTELKRQLLAEPPSVFVGVDAPDFNFGLEHPLRDAGIPTVHFVCPSIWAWRGGRIKKIAKAVDHMLCVFPFETALLEKAGVAASYVGHPLADEIPLVPDTLGARRALGLAEEGPIIAVLPGSRRSEIDLIGPTFFAAIEMMQHQEPALRFVMPAATPALREMLRPLVDSHPGLALTITDGQSQLAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAGRFVVPEILQHFATPQALAEATLKQLRDENNRRTLTEIFTEMHHVLKQNTAQRAAEVVASVIEKRKARP
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: SYW_XYLFA
Sequence: MGHFMSIRVLTGITTSGTPHLGNYVGAIRPAIRAAGAPGTESFYFLADLHSLIKVQDPERTQRSTLEIAATWLACGLDPEKVWLYRQSDVPEITELMWLLTCVAGKGILNRAHAYKAVVDKNRSEGGDDDAGITAGLFMYPVLMAADILLFNAHQVPVGRDQIQHIEMARDFAQRFNHIYGGEYFVLPEAAIDEQVATLPGLDGRKMSKSYGNTMPLFCTREELKKYVFSIVTDSRAPGEPKEAVGSAVFQLYQAFAGVEECSMFAQALAEGLGWGEAKVRLFERIDAEVAPLRERYEDFMRRPADIEAMLCDSAGRLRERDAIPLLARLREAVGLRSLSLCMASAVPVPQEKVALPVLKQYREQDGRFYFKLIDGQGAVLVQSRGFASPRDAGQWIALFKQAVSAEALVSPMLEPVADPVVVLAALRRLREAG
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPD3_YEAST
Sequence: MVYEATPFDPITVKPSDKRRVAYFYDADVGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVTPDNLEMFKRESVKFNVGDDCPVFDGLYEYCSISGGGSMEGAARLNRGKCDVAVNYAGGLHHAKKSEASGFCYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGTGELRDIGVGAGKNYAVNVPLRDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQCGGDSLSGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGGGYTMRNVARTWCFETGLLNNVVLDKDLPYNEYYEYYGPDYKLSVRPSNMFNVNTPEYLDKVMTNIFANLENTKYAPSVQLNHTPRDAEDLGDVEEDSAEAKDTKGGSQYARDLHVEHDNEFY
What is the function of this protein?
Catalytic component of the RPD3 histone deacetylase (HDAC) complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events.  Is involved in rDNA and telomere silencing and in double strand breaks repair.  Required for both full transcription repression and activation of many genes including cell type-specific genes (STE6, TY2 and HO), cell differentiation-specific genes (SPO13), genes that respond to external signals (PHO5) and TRK2.  The RPD3 complexes regulate also chromosomal replication timing.
What are the official names of this protein?
Histone deacetylase RPD3, Transcriptional regulatory protein RPD3.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.