PharMolix/UniProtQA huggingface dataset:
Protein: ATG4B_XENLA
Sequence: MDAATLTYDTLRFADTPDFPETAEPVWVLGRKYSALTEKEQLLNDITSRLWFTYRRNFQAIGGTGPTSDTGWGCMLRCGQMIFAQALICRHVGRDWRWDKQKPKGEYLNILTAFLDKKDSYYSIHQIAQMGVGEGKYIGQWYGPNTVAQVLRKLAVFDQWSSIAVHIAMDNTVVVDEIRRLCRAGSGESSDAGALSNGYTGDSDPSCAQWKPLVLLIPLRLGLSEINEAYIETLKHCFMVPQSLGVIGGRPNSAHYFIGYVGDELIYLDPHTTQLSVEPSDCSFIEDESFHCQHPPCRMHVSEIDPSIAVGFFCSSQEDFEDWCQHIKKLSLSGGALPMFEVVDQLPLHLSNPDVLNLTPDSSDADRLDRFFDSEDEEFEILSL
What is the function of this protein?
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.  Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy.  The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine.  Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy.  Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3.  In addition to the protease activity, also mediates delipidation of ATG8 family proteins.  Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy.  Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS).
What are the official names of this protein?
Cysteine protease ATG4B, Autophagy-related protein 4 homolog B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Cytoplasmic vesicle, autophagosome. Endoplasmic reticulum. Mitochondrion. Note=Mainly localizes to the cytoplasm, including cytosol.
Protein: ARGA_PSEAB
Sequence: MPDYVNWLRHASPYINSHRDRTFVVMLPGEGVEHPNFGNIVHDLVLLHSLGARLVLVHGSRPQIEARLAARGLAPRYHRDLRVTDAPTLECVIDAVGSLRIAIEARLSMDMAASPMQGARLRVAGGNLVTARPIGVVEGVDYHHTGEVRRIDRKGIGRLLDERSIVLLSPLGYSPTGEIFNLACEDVAMRAAIDLEAEKLILYGAEQGLLDASGKLVRELRPQQVPAHLQRLGNSYQAELLDAAAQACRAGVKRSHIVSYTEDGALLSELFTRTGNGTLVAQEQFEQLREAGIEDVGGLIELIRPLEEQGILVRRSREVLEREIEQFSIVEREGLIIACAALYPIADSEAGELACLAVNPEYRHGGRGDELLERIEERARGLGLKTLFVLTTRTAHWFRERGFQPSSVERLPAARASLYNFQRNSQVFEKSL
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSXC_ECO7I
Sequence: MLKLFSAFRKNKIWDFNGGIHPPEMKTQSNGTPLRQVPLAQRFVIPLKQHIGAEGELCVSVGDKVLRGQPLTRGRGKMLPVHAPTSGTVTAIAPHSTAHPSALAELSVIIDADGEDCWIPRDGWDDYRSRSREELIERIHKFGVAGLGGAGFPTGVKLQGGGDKIETLIINAAECEPYITADDRLMQDCAAQVVEGIRILAHILQPREILIGIEDNKPQAISMLRAVLADSHDISLRVIPTKYPSGGAKQLTYILTGKQVPHGGRSSDIGVLMQNVGTAYAVKRAVIDGEPITERVVTLTGEAIARPGNVWARLGTPVRHLLNDAGFCPSADQMVIMGGPLMGFTLPWLDVPVVKITNCLLAPSANELGEPQEEQSCIRCSACADACPADLLPQQLYWFSKGQQHDKATTHNIADCIECGACAWVCPSNIPLVQYFRQEKAEIAAIRQEEKRAAEAKARFEARQARLEREKAARLERHKSAAVQPAAKDKDAIAAALARVKEKQAQATQPIVIKAGERPDNSAIIAAREARKAQARAKQAKLQQTNDAATVADPRKTAVEAAIARAKARKLEQQQANAEPEQQVDPRKAAVEAAIARAKARKLEQQQANAEPEQQVDPRKAAVEAAIARAKARKLEQQQANAEPEQQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQKQANAVPEEQVDPRKAAVAAAIARVQAKKAAQQKVVNED
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rsx electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RGP2_ARATH
Sequence: MVEPANTVGLPVNPTPLLKDELDIVIPTIRNLDFLEMWRPFLQPYHLIIVQDGDPSKKIHVPEGYDYELYNRNDINRILGPKASCISFKDSACRCFGYMVSKKKYIFTIDDDCFVAKDPSGKAVNALEQHIKNLLCPSSPFFFNTLYDPYREGADFVRGYPFSLREGVSTAVSHGLWLNIPDYDAPTQLVKPKERNTRYVDAVMTIPKGTLFPMCGMNLAFDRDLIGPAMYFGLMGDGQPIGRYDDMWAGWCIKVICDHLSLGVKTGLPYIYHSKASNPFVNLKKEYKGIFWQEEIIPFFQNAKLSKEAVTVQQCYIELSKMVKEKLSSLDPYFDKLADAMVTWIEAWDELNPPAASGKA
What is the function of this protein?
UDP-L-arabinose mutase involved in the biosynthesis of cell wall non-cellulosic polysaccharides.  Catalyzes the interconvertion of UDP-L-arabinopyranose (UDP-Arap) and UDP-L-arabinofuranose (UDP-Araf) in vitro.  Preferentially catalyzes the formation of UDP-Arap from UDP-Araf.  At thermodynamic equilibrium in vitro the ratio of the pyranose form over the furanose form is 95:5.  Is not active on other UDP-sugars (UDP-Gal, UDP-Xyl, UDP-Glc, GDP-Man and GDP-Fuc) (PubMed:21478444).  Functions redundantly with RGP2 and is essential for proper cell walls and pollen development.  Probably involved in the formation of the pectocellulosic cell wall layer intine.  Is probably active as heteromer in vivo (PubMed:17071651).
What are the official names of this protein?
UDP-arabinopyranose mutase 2, Reversibly glycosylated polypeptide 2, AtRGP2, UDP-L-arabinose mutase 2.
What is the protein family that this protein belongs to?
Belongs to the RGP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus. Note=Soluble and membrane-associated.
Protein: FADJ_CROS8
Sequence: MESTSAFNLQMRPDNVAVVTIDVPGEKMNTLKAEFARDVRAIVKTLRENRDLAGVVFISAKPDNFIAGADINMIAHCQSAQEAEALASQGQQIMAEIRALPVHVVAAIHGACLGGGLELALACHSRICTDDVKTLLGLPEVQLGLLPGSGGTQRLPRLVGVSTALEMILAGKQLRPRQALKAGLVDDVVPQSILLEAAAELAKKRRPAPRRLPVRERLLAGPIGRALLFRMVTQKTHQKTHGNYPAAQRIIDVVRTGLEQGSASGYQAEARAFGELAMTPESAALRGLFFATTELKKETGSEAAPRALHSVGVLGGGLMGGGIAYVTATKARLPVRIKDISEKGINHALKYSWDLLEKKVRRRHLRASERDAQMALISASTDYRGFHQRDIVVEAVFEDLTLKQNMVAEIEAHTAPHTIFASNTSSLPIGDIAAGATRPEQVIGLHYFSPVDKMPLVEVIPHAGTSAETIATTVQLAKKQGKTPIVVADCAGFYVNRILAPYINEAMRCLMEGESIEKIDEALVKRGFPVGPIQLLDEVGIDVGTKIMPVLERAYGPRFSAPGDAVAAILNDDRKGRKNGRGFYLYPAKGRKSKKQVDPAVYGLIGVKPGGKLSGEEIAERCVMMMLNEAARCLDEGVVRSARDGDIGAVFGIGFPPFLGGPFRYMDTLGAAAMATTLTRLATRYGDRFTPCDRLLRMAQTGQTFWLAGNLQAEMTV
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VEGFA_CANLF
Sequence: MNFLLSWVHWSLALLLYLHHAKWSQAAPMAGGEHKPHEVVKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEEFNITMQIMRIKPHQGQHIGEMSFLQHSKCECRPKKDRARQEKKSIRGKGKGQKRKRKKSRYKPWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
What is the function of this protein?
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.  Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels.  Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).  Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Protein: RL23_XYLF2
Sequence: MNSSCEKIFGVLRSPRVSEKSSRLQEISNVYVFEVSSDATKIDVKNAVERLFDVKVGVVRVLNVKGKSKSFRNRGGSRSGWRKAYVRLIDGQSIDVASSV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: Y420_AQUAE
Sequence: MKRFRKNNLELELIRELSEIDFYNISAPLNSKEFWKEWQEKFNRANLTRIALRNILRNKRLSPKEYRKVKNSIKKYEDIINYLNALKLTALNARGSFGGYFIEFDEDEEENEGGT
What are the official names of this protein?
Uncharacterized protein aq_420.
Protein: RECX_LACLS
Sequence: MGKITAIKKLKRLYRVDLSDLDEEKIYLCEDTIIHFFITIDKEVSETDLEEILAYDQFAQGKSLALYYISFKMRTGAEVRKYLLEHDINDTDQIEQVLSVLTENNLINDKSYAENFIEGKISMGSSGPYQIKQKLLTKGISNDVLSEALKEIYSEEKQIDVAYKLASKLSRTYGTRLTLKQLKDKIIQNLMNKGFSYSVSSIALDSLELEADEENEMDLLYSELDKVAKRYTKNYEGYERKQKITQALARKGFSYDDISSALRDYTFPE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_AQUAE
Sequence: MPRLKTRREKRLRRHKRIRKKVFGTPERPRLCVYRSLKHFYAQIIDDTIGHTLVSASTLDPEFEKITGKRGGKSIKDAEVVAEIIARRALEKGIKKVVFDRGGFKYHGKIKAFADKCREMGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: NADA_SALPK
Sequence: MSVMFDPQAAIYPFPPKPTPLNDDEKQFYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHAASTLLVAGVRFMGETAKILSPEKNILMPTLAAECSLDLGCPIDEFSAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIEHLDSLGEKIIWAPDRHLGNYVQKQTGADVLCWQGACIVHDEFKTQALTRLKKIYPDAALLVHPESPQSIVEMADAVGSTSQLIKAAKTLPHRQLIVATDRGIFYKMQQAVPEKELLEAPTAGEGATCRSCAHCPWMAMNGLKAIAEGLEQGGAAHEIQVDAALREGALLPLNRMLDFAATLRA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_CLOBA
Sequence: MKQGIHPEYHTDAVVKCACGNSFTTGSVKEELKVEICSKCHPFFTGKQKIVDVGGRVEKFNKRFNLDTK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: ZN251_HUMAN
Sequence: MAATFQLPGHQEMPLTFQDVAVYFSQAEGRQLGPQQRALYRDVMLENYGNVASLGFPVPKPELISQLEQGKELWVLNLLGAEEPDILKSCQKDSEVGTKKELSILNQKFSEEVKTPEFVSRRLLRDNAQAAEFREAWGREGKLKERVGNSAGQSLNKPNIHKRVLTEATVGRERSLGERTQECSAFDRNLNLDQNVVRLQRNKTGERVFKCDICSKTFKYNSDLSRHQRSHTGEKPYECGRCGRAFTHSSNLVLHHHIHTGNKPFKCDECGKTFGLNSHLRLHRRIHTGEKPFGCGECGKAFSRSSTLIQHRIIHTGEKPYKCNECGRGFSQSPQLTQHQRIHTGEKPHECSHCGKAFSRSSSLIQHERIHTGEKPHKCNQCGKAFSQSSSLFLHHRVHTGEKPYVCNECGRAFGFNSHLTEHVRIHTGEKPYVCNECGKAFRRSSTLVQHRRVHTGEKPYQCVECGKAFSQSSQLTLHQRVHTGEKPYDCGDCGKAFSRRSTLIQHQKVHSGETRKCRKHGPAFVHGSSLTADGQIPTGEKHGRAFNHGANLILRWTVHTGEKSFGCNEYGKAFSPTSRPTEDQIMHAGEKPYKCQECGNAFSGKSTLIQHQVTHTGQKPCHCSVYGKAFSQSSQLTPPQQTRVGEKPALNDGSKRYFIHIKKIFQERHF
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 251.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZDHC1_ARATH
Sequence: MRKHGWQLPYHPLQVVAVAVFLALGFAFYVFFAPFVGKKIHQYIAMGIYTPLITCVVGLYIWCAASDPADRGVFRSKKYLKIPENGKFPLAKDIKDGCGSATGGAKSHDGTCVEDTENGSNKKLESSERSSLLRLLCSPCALLCSCCSGKDESSEQMSEDGMFYCSLCEVEVFKYSKHCRVCDKCVDRFDHHCRWLNNCIGKRNYRKFFSLMVSAIFLLIMQWSTGIFVLVLCLLRRNQFNADIALKLGSSFSLIPFVIVVGVCTVLAMLATLPLAQLFFFHILLIKKGISTYDYIVALREQEQELEAGGGQQSPQMSMISSFTGLSSASSFNTFHRGAWCTPPRLFLEDQFDVVPPENASVSSYGKKSVVEERVKKKPQPVKISPWTLARLNAEEVSKAAAEARKKSKIIQPVARRENPFVGLEASSSFGSSGRRMFPTKYEGVNNNGKQRRQSKRIRLPAELPLEPLMNVQTKAAMETSTSSGLAPLQLEARSAFQTSRAMSGSGNVMVTSSPESSLDSHDIHPFRVSSEAEDAAQLNGFSSAVGLMGQQRGQQQQQQLSMMMMPLSRSTSDGYDASGGEDSDQVPSRNIHKSR
What is the function of this protein?
Palmitoyl acyltransferase.
What are the official names of this protein?
Probable protein S-acyltransferase 22, Probable palmitoyltransferase At1g69420, Zinc finger DHHC domain-containing protein At1g69420.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: NS1_I76A6
Sequence: MDSNTVSSFQVDCFLWHVRKQIVDQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATHVGKQIVEKILKEESDEALTMTMASTPASRYITDMTTEELSRDWFMLMPKQKVEGPLCIRIDQAIMDKNIMLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSFPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKTLQRFAWGSSNEDGGPPLTPKQKRKMARTTRSKVRRDKMAD
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: Y176_HERAR
Sequence: MRLPTFLKRPRTARQIVGQMGEDEALRYLQKQGLALIERNFRCKGGEIDLVMQDGDTLVFVEVRKRADKNHGGAAASVTPEKQKRLIVAAHIFLQRYKMPPACRFDVIAIDATEMNWLKNAIES
What are the official names of this protein?
UPF0102 protein HEAR0176.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RS14_PROMP
Sequence: MAKKSMIAREVKRKKLVKKYATKRKSLLDEFNAAKDPMERLEIHRKIQGLPRNSAPTRVRNRCWATGKPRGVYRDFGLCRNQLRLRAHNGELPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: SEPF_STRT1
Sequence: MAIKDAIEKIVSYFDADEVTDHEDVAKERPVKVQKTEQTPSQQQRKPERPQETVPPRRQHIKSDVQETQVLRSLSLSRSQVNQGSQQMNTTKTTIAIKYPKKYEDAQEIVELLIENECVLIDFQYMLEAQARRCLDFIDGASKVLTGNLQKVGSSMYLLTPINVVVDIEEIGLSHGNQESTFDFDMKRR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: IF1_HAEDU
Sequence: MAKEDCIEMQGTILETLPNTMFRVELENGHIVAAHISGKMRKNYIRILTGDKVTVEMTPYDLSKARIIFRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_COXB2
Sequence: MLYYPHIDPVAFRLGPLKVHWYGLMYLVGFAMAWGLALYRARDPKRHWTAQQVGDLIFYGALGLIIGGRLGYMLFYDFSNFIANPLTLFQVWRGGMSFHGGLIGVIVTTWIFSRRTHKRWMDVTDFVVPLVPLGLAAGRIGNFINGELWGRVTTVPWGMVFPNAGPLPRHPSQLYEFLLEGVLLFIVIWWFSAKLRPRFAVSSLFLLCYGLFRFTAEFFRQPDPQLGFVAFGWLTRGQELSLPMIIIGGFALWWAYRHKER
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRPE_XANCP
Sequence: MNQDHPEFDSEDLSQNPPETDPLKAEIESLRSEIALVKADALRERADLENQRKRIARDVENARKFANEKLLGELLPVFDSLDAGLTAAGTEPSPLRDGLDLTYKQLLKVAADNGLTLLDPVGQPFNPDQHQAISQGEAEGIAPGHVVQVFQKGYLLNERLLRPALVVVAKHD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHA2_STAAN
Sequence: MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSSPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
What is the function of this protein?
May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.
What are the official names of this protein?
Alanine dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
Protein: SHU2_KLULA
Sequence: MSQGQERFLNYSQLLSELVDGRGRTLNDTTVAFLYQLFPNDLFVKAFSLLETHNLFLYVWDSIDDVALNDGVQCSDAEIDETSNSVAGSRLPTEGHQCHSKRNSNDNDISRLANMLYDLETRSKTLHRIIVQSVDEEVSKKPIYVDVTAWFCSCNEYTKCFSGMLHNNGDEGYQGMFETYGNETDDNFAKVNSHTHVNSSKVICQHLLAAAILLQTSLKVLKYFTSVKQSVSLFSINNKDDWLKLHLNIVD
What is the function of this protein?
Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase.  Required for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation (By similarity).
What are the official names of this protein?
Suppressor of hydroxyurea sensitivity protein 2.
What is the protein family that this protein belongs to?
Belongs to the SHU2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATN2_SCHOC
Sequence: MSSINTNVAEKHSYKERVNTDASSLSADGSVEAHRLTIEQVAKIFNTDIINGLSTSQANQTLKDFGANTLGDGDKISLTKIIAHQVCNAMILVLIISMVIALAIKDWISGGVIGFVVLINISVGFVQEYKAEKTMGSLRSLSSPTARVTRNGDDTTIPAEEVVPGDIVHIKVGDTVPADLRLIDLMNLETDEALLTGESLPITKNHLDVYDDYSVPIPVGDRLNLAYSSSVVSKGRGTGIVIATALDTQIGQIAKSLRNNNSVIRKVDKSNGKPKKREYSKAFCGTIKDIFYNILGINVGTPLQRKLSWLAIFLFWGCRYFCNYCNGIPKNRVNKEVAIYAICVALSMIPSALIVVLTITMAVGAQVMVMKHVIVRKLDSLEALGGINDICSDKTGTLTQGKMIARKTWIPNVGTFNVGNSNDPFNPKAGEVSFVNLSPKFIEETDEEIDFKQKLPSPFPENFNNWLLTATLANIATLNQSRDEETGELVWKAHGDATEIAIQVFTSRLNYGRDSLIENYEHLAEFPFDSSIKRMSAVYQSLQTNQIKVYTKGAVERVLNCCTHWYGHEENDELYDNQQLKELTDDDKHLIESNMNALSTQGLRVLAFATKDITNSSIDLSNRESIESNLIFQGLIGIYDPPRPETAGSVKSCHNAGINVHMLTGDHPGTAKAIAQEVGILPHNLYHYSEEVVKAMCMTANEFDSLSDDEIDKLPVLPLVIARCAPQTKVRMIEALHRRGKFVAMTGDGVNDSPSLKKADVGIAMGLNGSDVAKDASDIVLTDDNFASILNAIEEGRRMSSNIQKFVLQLLAENVAQALYLMVGLAFIDDSGLSVFPLSPVEVLWILVVTSCFPAMDLGQERASDDILEESPNSTIFTWEVIIDMIVYGFWMAVCCLVCFVIIVYGEGDPYLGVNCNKSSSSNSDVCELVFRGRSASFATMTWCALILAWECIHPYNSLFYMRQDTDHPWWKQTVIDLWDNQFLFWSVAIGFISVFPVVYIPVINTKVFLHGPIGYEWGLAVGFSILFLAGSELWKWIKRIHKRKANKKAKNPEYELERSDPFKKYASFSRSNTMDRPELMV
What is the function of this protein?
Catalyzes the hydrolysis of ATP coupled with the export of sodium and potassium from the cell (PubMed:9430707).  May be an inefficient sodium exporter (PubMed:9430707).  May transport other cations such as lithium (By similarity).  Sodium/potassium efflux ATPases are involved in salt tolerance and maintaining the membrane potential across the plasma membrane in high salinity (Na+) or alkaline (K+) environments (PubMed:9430707).
What are the official names of this protein?
Sodium/potassium exporting P-type ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.
Protein: IKBL_ASFB7
Sequence: MEHMFPEREIENLFVKWIKKHIRNGNLTLFEEFFKTDPWIVNRCDKNGSSVFMWICIYGRIDFLKFLFEQESYPGEIINPHRRDKDGNSALHYLAEKKNHLILEEVLGYFGKNGTKICLPNFNGMTPVMKAAIRGRTSNVLSLIKFGADPTQKDYHRGFTAWDWAVFTGNMELVKSLNHDYQKPLYMHFPLYKLDVFHRWFKKKPKIIITGCKNNVYEKLPEQNPNFLCVKKLNKYGK
What is the function of this protein?
I-kappa-B- (IkB)-like protein that inhibits the binding of NF-kappa-B to DNA, thereby down-regulating pro-inflammatory cytokine production (By similarity).  Forms a heterodimer with the NF-kappa-B subunit RELA/p65 and prevents the activation of the NF-kappa-B transcription factor (PubMed:10934190).  Also inhibits the host calcineurin phosphatase activity, which is required for the induction of nuclear factor of activated T cells(NFAT)-dependent immune response genes (By similarity).  Inhibits calcineurin function, which is required for the induction of nuclear factor of activated T cells (NFAT)-dependent immune response genes (By similarity).  Prevents the binding of substrates to calcineurin without affecting the phosphatase activity (By similarity).  Does not contain the serine residues that are phosphorylated by host IkB kinase and thus is not degraded following stimulation of the NFkB pathway (PubMed:10934190).
What are the official names of this protein?
IkB-like protein, Ankyrin repeat domain-containing protein A238L, p28.
What is the protein family that this protein belongs to?
Belongs to the asfivirus A238L family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Binding to host PPP3CA/Calcineurin may mask the second nuclear localization signal thereby contributing to the cytoplasmic retention of A238L.