PharMolix/UniProtQA huggingface dataset:
Protein: TOR1A_MOUSE
Sequence: MKLGRAALALLLLAPCVVRAVEPISLSLALAGVLTTYISYPRLYCLFAECCGQMRSLSREALQKDLDNKLFGQHLAKKVILNAVSGFLSNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSDYVHLFVATLHFPHASNITQYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDVVDEVSYQKAIFIFLSNAGAERITDVALDFWKSGKQREEIKLRDMEPALAVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEVDEDIISKVAEEMTFFPKEEKVFSDKGCKTVFTKLDYYLDD
What is the function of this protein?
Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates.  Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN).  In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity.  Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission.  In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding.  May have a redundant function with TOR1B in non-neural tissues.
What are the official names of this protein?
Torsin-1A, Dystonia 1 protein, Torsin ATPase 1, Torsin family 1 member A.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. Torsin subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane. Synapse, synaptosome. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2.
Protein: MUTL_SHEAM
Sequence: MAIQVLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIDIDKGGSKLIRIRDNGGGIPKAELALALARHATSKVQTLEDLEAILSFGFRGEALASISSVSRLTLTSRTTEQAEAWQAYAEGSEVAIRVMPAAHPVGTTIEVADLFFNTPARRRFLKSDKTEFTHIDEWLKRIALIRSDVHFSLSHNGKPVRQYRCAATDTQYLQRLAQVAGRAFADSAIKVDCQHDGMGLSGYLQSPALSDMVDCHYFYVNGRLIRDRLVNHAVRQAFGELGTFEQPAFVLSLTLDPHQVDVNVHPAKHEVRFHQARYVHDFILQVLQSALSQMQDLPLAEELPRAQESPASVREHTAGYAPYTFNRDAATEAAGVLSSLPDTQRSQRQPEKAASGQRSSVDAGLSQGSSAHRASQTGLGQSGNAATFETSERHGSGYSGAGQGQRYVRDQLSGQQRQAAQYYAELLHTPEVVSTSGSLQAGLPMPPLLAGRYWVLAQDEHLRLLSISDAAKALVVQEILSKLPTGLVGQPLLMPVAVAADADWTMILAERESLLRRLGLELTIRYQQLIIKKVPPYLRDSQLAKLIPEFLEWIKLEVPADEALCHWLAQYVTGFDAAPKVWQRIQSLEATERNKILESARDLPWQTWLDEYKH
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: HBA1_NOTAN
Sequence: SLSDKDKAAVRALWSKIGKSADAIGNDALSRMIVVYPQTKTYFSHWPDVTPGSAHIKAHGKKVMGGIALAVSKIDDLKAGLSDLSEQHAYKLRVDPANFKILNHCILVVISTMFPKDFTPEAHVSLDKFLSGVALALAERYR
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1, Alpha-1-globin, Hemoglobin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CAIE_ECO81
Sequence: MSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFRGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQMEENRPRLQGTTDVMPKR
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: Y2324_STRCO
Sequence: MIRFEDVSVTYDGATEPTVRAVDFEVPEGELVLLAGPSGVGKSTVLGAVGGLVPHFTGGTLRGRVTVAGRDTRTHKPRELADVVGTVGQDPLSHFVTDTVEDELAYGMESLGLPPDVMRRRVEETLDLLGLSDLRSRPIATLSGGQQQRVAIGSVLTPHPDVLVLDEPTSALDPAAAEEVLAVLQRLVHDLGTTVLMAEHRLERVIQYADQVVLLPAPGEAPLIGAPAEVMAVSPVYPPVVGLGRLAGWSPLPLTIRNARRRAAPLRERLAGREIPDHTPPPSAPLPAPPAPRPVTSRWRRRGKRPENPSAPTPYAAEVRSLAVRRDRVQALRHVDLTVSPGETVALMGRNGAGKSTLLSALVGLVEPSAGSVRAGDAVPHRTAPRDLVRRVGLVPQEPRDLLYADTVAAECAAADRDADAAPGTCRALLSELLPGITDDIHPRDLSEGQRLTLALSVVLTARPPLLLLDEPTRGLDYAAKARLAGILRGLAAEGHAIVLATHDVELAAELAHRVVLLAEGEVIADGPAADVVVASPSYAPQVAKVLAPRKWLTVAQVREALT
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein SCO2324.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: IBPA_YERPG
Sequence: MRNSDLAPLYRSAIGFDRLFNLLESGQNQSNGGYPPYNVELVDENNYRIAIAVAGFAEQELEITTQDNLLIVRGSHANEPAQRTYLYQGIAERNFERKFQLAEHIKIKGANLVNGLLYIDLERLVPESLKPRRIEIK
What is the function of this protein?
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpA, 16 kDa heat shock protein A.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MER_METKA
Sequence: MAEVSFGIELLPDDKPTKIAHLIKVAEDNGFEYAWICDHYNNYSYMGVLTLAAVITSKIKLGPGITNPYTRHPLITASNIATLDWISGGRAIIGMGPGDKATFDKMGLPFPCKIPIWNPEAEDEVGPATAIREVKEVIYQYLEGGPVEYEGKYVKTGTADVNARSIQGSDIPFYMGAQGPIMLKTAGEIADGVLVNASNPKDFEVAVPKIEEGAKEAGRSLDEIDVAAYTCFSIDKDEDKAIEATKIVVAFIVMGSPDVVLERHGIDTEKAEQIAEAIGKGDFGTAIGLVDEDMIEAFSIAGDPDTVVDKIEELLKAGVTQVVVGSPIGPDKEKAIELVGQEVIPHFKE
What is the function of this protein?
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
What are the official names of this protein?
5,10-methylenetetrahydromethanopterin reductase, Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase, Methylene-H(4)MPT reductase.
What is the protein family that this protein belongs to?
Belongs to the mer family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACEK_ACISJ
Sequence: MFPERLDAPQAYDIAKAMMDGFNRHYRLFRAESARAKHRFETADWHGQQRAQRERIEFYDLRVRECVRRLDKEFNAGALPMDVWHQIKLHYIGLMVNHLQPELAETFFNSVTTKILHRTHFHNDFIFVRPAVSTEYIESDDPGARPTYRAYYPSRDNLHETVVRIVEHCALQRDFENLPRDAGHVVQALQQRLGAVKLRTNFQVQVLSSLFFRNKGAYLVGKVINGYNELPFALPILHGEDGRLLIDAVLFGENDLQMLFSFARAYFMVDMEIPSAYVQFLRSLMPRKPRAELYTALGLAKQGKTLFYRDFLHHLRYSTDKFRIAPGIKGMVMLVFDLPSFPYVFKLIKDQFPAPKDTTREQVQGKYLLVKQHDRVGRMADTLEYSLVAFPRERFSDELIEEIRRHAPSQIEISDRDGDGRQEVIIAHLYIERRMIPLNIHLQECFDTGLDKPEARSALEHAVTEYGNAIKDMVAANIFPGDMLWKNFGITRNGKVVFYDYDEIEYLTDCNFRRVPPPRCEEDEVSGEVWWPVGPHDVFPETFGPFLLGNDSVREAFMRHHADLLDVEFWQSHKERIQAGHLYDVFPYDSARRFRCASPSSFQTQGDST
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_STAAE
Sequence: MSKQRIYEYAKELNLKSKEIIDELKSMNIEVSNHMQALEDDQIKALDKKFKKEQKNDNKQSTQNNHQKSNNQNQNKGQQKDNKKNQQQNNKGNKGNKKNNRNNKKNNKNNKPQNQPAAPKEIPSKVTYQEGITVGEFADKLNVESSEIIKKLFLLGIVANINQSLNQETIELIADDYGVEVEEEVVINEEDLSIYFEDEKDDPEAIERPAVVTIMGHVDHGKTTLLDSIRHTKVTAGEAGGITQHIGAYQIENDGKKITFLDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTIEAINHAKEAEVPIIVAVNKIDKPTSNPDRVMQELTEYGLIPEDWGGETIFVPLSALSGDGIDDLLEMIGLVAEVQELKANPKNRAVGTVIEAELDKSRGPSASLLVQNGTLNVGDAIVVGNTYGRIRAMVNDLGQRIKTAGPSTPVEITGINDVPQAGDRFVVFSDEKQARRIGESRHEASIIQQRQESKNVSLDNLFEQMKQGEMKDLNVIIKGDVQGSVEALAASLMKIDVEGVNVRIIHTAVGAINESDVTLANASNGIIIGFNVRPDSGAKRAAEAENVDMRLHRVIYNVIEEIESAMKGLLDPEFEEQVIGQAEVRQTFKVSKVGTIAGCYVTEGKITRNAGVRIIRDGIVQYEGELDTLKRFKDDAKEVAKGYECGITIENYNDLKEGDVIEAFEMVEIKR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_SHEDO
Sequence: MSTIPTDLKFASSHEWVRKEDDGSYTVGITEHAQELLGDMVFVELPEVGDSVSAGAECAVAESVKAASDIYAPISGEVVAVNSSLEDSPELVNSDAYGDGWFFRIMPSDESEVDALLDAEGYQDVIDEA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: SLX1_NEOFI
Sequence: MEDIQIEHPRPIPIFYCCYLLRSTVRHASLYIGSTPNPARRLVQHNGVVKGGARRTAAEKLRPWEMLLVVEGFTSRLAALQFDSAPAEVKHRRKRKAKSGDPESLDSNCDSAKTKDKGTPKKSKRRPRPPRSLDTHFSDLHRLLRSTYFSHRPLKIRFFSGDIYQSWKAWYDRVDVRLRSPVKVILDGSCPEIGAHASGNDTRFGGVENAKITYATIQDYIEKAIFLLDDPKDVRCHVCQGQIVPKEELTTVCPQAECHCTCHLLCLSRKFIDAAEEPNQIVPRHGICPACEATVEWPLMMKELSFRSRAKQELLEILKRKRRVDRKQSVVTGKVESSSRRSVSVDLDDRFGQDAEDEFLLDEDWWDGLASESDSDADRRLKTLSKAAPKLETVIEDSECDDAEIL
What is the function of this protein?
Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit slx1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: XYNA_PRERU
Sequence: MRKLTQFCLGLMLLPIAAVAQNQPTMKDVLGKYFLVGTALNSHQIWTHDPKIVHAITDNFNSVVAENCMKGEIIHPEEDYYDWHDADQLVKFAEQHKMTVHGHCLVWHSQAPKWMFTDKEGKEVTREVLIDRMYHHITNVVKRYKGKIKGWDVVNEAILDNGEYRQSPYYKIIGPDFIKLAFIFAHQADPDAELYYNDYSMSIPAKRNAVVKLVKELKAAGCRIDAVGMQSHNGFNYPNLEDYENSIKAFIAAGVDVQFTELDVNMLPNPKSFGGAEISQNYKYNKELNPYVNGLTKAAQKTFDQQYLSFFKIYRKYVDHIKRVTVWGVDDGSSWLNGWPVPGRTNYGLLIDRNYKVKPVVKEIIKLYE
What are the official names of this protein?
Endo-1,4-beta-xylanase A, Xylanase A, 1,4-beta-D-xylan xylanohydrolase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
Protein: CML2_MOUSE
Sequence: MEVSKEMLFEELDNYSYALDYYSQESDPEEKVYLGLVHWISLFLYALAFVLGIPGNAIVIWLMGFKWKKTVTTLWFLNLAIADFIFVLFLPLYISYVALSFHWPFGLWLCKVNSFIAQLNMFSSVFFLTVISLDRYIHLLHPGLSHRHRTLKSSLVVVILVWLLASLLGGPTLYFRDTMEVNNHIICYNNFQEHELTLMRHHVLTWVKFLFGYLFPLLTMSSCYLCLIFKMKKRNILISRKHLWMILSVVIAFLVCWTPYHLFSIWELSIHHNSSFQNVLQGGIPLSTGLAFLNSCLNPILYVLISKTFQARFRASVAEVLKRSLWEASCSGTVSEQLRSAETKSLSLLETAQ
What is the function of this protein?
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:24895415).  Signals mainly via beta-arrestin pathway.  Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too.  Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (PubMed:29799787).
What are the official names of this protein?
Chemerin-like receptor 2, Chemerin chemokine-like receptor 2, Chemokine-like receptor 2, G-protein coupled receptor 1.
What is the protein family that this protein belongs to?
Belongs to the chemokine-like receptor (CMKLR) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Internalizes in presence of its ligand, TAFA1 (PubMed:29799787). Internalizes efficiently in response to RARRES2 (By similarity).
Protein: AROC_RHOP2
Sequence: MSFNTFGHMFRVTTFGESHGVAIGCVVDGCPPLIPLTEADIQGDLDRRRPGQSRFTTQRQEADQVKILSGVMAHPETGVQVTTGTPIALLIENTDQRSKDYSEIQNKFRPGHADFTYEAKYGIRDYRGGGRSSARETATRVAAGAVARKVIAGMTVRGALVQIGPHQIDRDKWDWAEIGNNPFFCPDKDKAAFFADYLDGIRKSGSSIGAVIEVVAEGVPAGLGAPIYAKLDTDLAAALMSINAVKGVEIGDGFATAALTGEENADEMRMGNAGPQFLSNHAGGILGGISTGQPVVARFAVKPTSSILSPRKTIDRAGHDTDILTKGRHDPCVGIRAVPVGEAMVACVLADHLLRHRGQVG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: Y1185_PARXL
Sequence: MAGHSKWANIKHKKAAADAKRGKVWTRLIKEIQVAARMGGGDIDSNPRLRLAVEKAYDANMPKDNVNRAIQRGVGGVDGASYEEIRYEGYGIGGAAVIVDTMTDNRTRTVAEVRHAFSKNGGNMGTDGSVSFMFDHVGQFLFAPGTPEDKLMEAALEAGAEDVVTNDDGSIEVLCPPNDFPKVKSALEAAGFKAELAEVTMKPQTEVEFTGEDAVKMQKLLDALENLDDVQEVYTNAAIAEE
What are the official names of this protein?
Probable transcriptional regulatory protein Bxeno_A1185.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAPA_BACMK
Sequence: MSQQKGNKSRINVEIYGQQYSVVGDESTSHIRMVAAIVDDKMRELNAKNPSLDTSRLAVLTAVNVIHDYIKLKEEHEKLKESMTQKGME
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell. In sporulating cells, localizes near the cell poles.
Protein: HBEAG_HBVC9
Sequence: MQLFHLCLIISCSCPTVQASKLCLGWL
What are the official names of this protein?
Truncated HBeAg protein.
Protein: NQOR_BURCM
Sequence: MAKVLVLYYSSYGHVETMAQHIAEGAKSVPGVEVTLKRVPETIPADQAKAIGVKVDQAAPVATVDELPNYDAIIFGTPTRFGNMAGQMRTFLDQTGGLWMKGALVGKIGSVFASTGTQHGGQETTITSFHTTLLHQGMVIVGVPYACSGLVNMSEITGGTPYGATTLAGADGSRQPSANELDIARYQGKHVAELAVKLAS
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: CDS1_CONLT
Sequence: MPKLEMMLLVLLILPLCYIDAVGPPPPWNMEDEIIEHWQKLHCHEISDLTPWILCSPEPLCGGKGCCAQEVCDCSGPACTCPPCL
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This toxin weakly inhibits alpha-9-alpha-10/CHRNA9-CHRNA10 nAChRs (IC(50)=3 uM).
What are the official names of this protein?
Alpha-conotoxin Lt28.1, Conotoxin Lt15.2, Conotoxin Lt28.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin D superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYI_SYNC1
Sequence: MDYKQTLNLPDTQFPMRGNLPKREPEILEKWQSMGLYEKMEEAGRTRPNFTLHDGPPYANGHIHIGHALNKILKDIVLKSRRMKGFYAPYVPGWDCHGLPIELMVDKKLGKKKRDMTKVEIRKECRVYADQWVKIQSEEFERLGVMGEWDRPYLTMTHHYEAVTARELARFVEKGGLFKGKKPIHWCSSCVTALAEAEVEYADHKSPSIYVKFPFDGELPAELNDLAGRKLSFVIWTTTPWTIPANLAVCLNPNLPYAVVETGDELLVMAEGLVSGVMQELGLENYRVLKTFEAPIFERKTCRHPFYDRPSLLILGDHVTLEAGTGCVHTAPGHGQDDYVVGLAYGLDVYNPVDNYGRYYEDVEFFGGMKINQANGAVNAKLTEVGALLKESEVSHSYPHCWRCKKPIIFRATEQWFISMEANGLREKALGHINDVNWVPRWGRDRIYNMVENRPDWCISRQRSWGVPITIFYCAKCGEALEDSKVMDYVADLFEEGGSDLWFDKPAKELMPAGTTCPGCGHDEFTKETDILDVWFDSGVSHAAVLDNRDYLSWPADLYLEGSDQHRGWFHSSLLASVGTRELTPYKSVLTHGFVVDGKGKKMSKSVGNVVAPEEVIKKYGAEILRLWVAAQDYRDDIRISNEILQRLSDAYRRIRNTARYILGNLSGFDPSRDMVADDQLLELDRWALAKLEDLAGRVEKAYEDYEFHIIYHAVHNFCSVEMSSFYLDVLKDRLYVSGTDSIARRSAQTAMYRILDCITRLIAPVLSFTAEEIWAFMPGERSESVHLGEFVQFPTSFRDAALEERYDNLLEIRSDVSKALELARNEKVIGHSLDARVLLSAPAGATLELLEKYRDQLASLFIVSQVELVDDLADGLTGENLPDLKVKVEKALGEKCERCWNYATSVGDSAEHPALCHRCVAVLTDR
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOS_MSVMM
Sequence: MARSTPCSQTSLAVPNHFSLVSHVTVPSEGVMPSPLSLCRCLPRELSPSVDSRSCSIPLVAPRRAGKLFLGTTPPRAPGLPRRLAWFSIDWEQVCLMHRLGSGGFGSVYKATYHGVPVAIKQVNKCTKDLRASQRSFWAELNIARLRHDNIVRVVAASTRTPEDSNSLGTIIMEFGGNVTLHQVIYGATRSPEPLSCREQLSLGKCLKYSLDVVNGLLFLHSQSILHLDLKPANILISEQDVCKISDFGCSQKLQDLRCRQASPHHIGGTYTHQAPEILKGEIATPKADIYSFGITLWQMTTREVPYSGEPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQNIIQSCWEARALQRPGAELLQRDLKALADSIEPM
What are the official names of this protein?
Serine/threonine-protein kinase-transforming protein mos.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: ICEN_ENTAG
Sequence: MKEDKVLILRTCANNMADHGGIIWPLSGIVECKYWKPVKGFENGLTGLIWGKGSDSPLSLHADARWVVAEVDADECIAIETHGWIKFPRAEVLHVGTKTSAMQFILHHRADYVACTEMQAGPGSPDVTSEVKVGNRSLPVTDDIDATIESGSTQPTQTIEIATYGSTLSGTHQSQLIAGYGSTETAGDSSTLIAGYGSTGTAGADSTLVAGYGSTQTAGEESSQMAGYGSTQTGMKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLIAGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLIAGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTSTAGYESSLIAGYGSTQTAGYGSTLTAGYGSTQTAQNESDLITGYGSTSTAGANSSLIAGYGSTQTASYNSVLTAGYGSTQTAREGSDLTAGYGSTGTAGSDSSIIAGYGSTQTASYHSSLTAGYGSTQTAREQSVLTTGYGSTSTAGADSSLIAGYGSTQTAGYNSILTAGYGSTQTAQEGSDLTAGYGSTSTAGADSSLIAGYGSTQTAGYNSILTAGYGSTQTAQEGSDLTSGYGSTSTAGADSSLIAGYGSTQTASYHSSLTAGYGSTQTAREQSVLTTGYGSTSTAGADSSLIAGYGSTQTAGYHSILTAGYGSTQTAQERSDLTTGYGSTSTAGADSSLIAGYGSTQTAGYNSILTAGYGSTQTAQENSDLTTGYGSTSTAGYDSSLIAGYGSTQTAGYNSILTAGYGSTQTAQENSDLTTGYGSTSTAGYESSLIAGYGSTQTASFKSTLMAGYGSSQTAREQSSLTAGYGSTSMAGYDSSLIAGYGSTQTAGYQSTLTAGYGSTQTAEHSSTLTAGYGSTATAGADSSLIAGYGSSLTSGIRSFLTAGYGSTLISGLRSVLTAGYGSSLISGRRSSLTAGYGSNQIASHRSSLIAGPESTQITGNRSMLIAGKGSSQTAGYRSTLISGADSVQMAGERGKLIAGADSTQTAGDRSKLLAGNNSYLTAGDRSKLTAGNDCILMAGDRSKLTAGINSILTAGCRSKLIGSNGSTLTAGENSVLIFRCWDGKRYTNVVAKTGKGGIEADMPYQMDEDNNIVNKPEE
What is the function of this protein?
Ice nucleation proteins enable bacteria to nucleate crystallization in supercooled water.
What are the official names of this protein?
Ice nucleation protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial ice nucleation protein family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: PRP2_MEDTR
Sequence: MASSNLLVLLLFALFAIPRGLANYDKPPVYQPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPIYKPPVEKPPVYKPPVEKPPVYKPPVEKPPIYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVEKPPVYKPPVYKPPVYKPPVEKPPVYKPPVYKPPVEKPPVYKPPVYKPPVEKPPVYGPPHHP
What is the function of this protein?
This is a developmentally regulated putative cell wall protein.
What are the official names of this protein?
Repetitive proline-rich cell wall protein 2.
What is the protein family that this protein belongs to?
Belongs to the plant proline-rich protein superfamily. ENOD12 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: YDFG_ECO57
Sequence: MIVLVTGATAGFGECITRRFIQQGHKVIATGRRQERLQELKDELGDNLYIAQLDVRNRAAIEEMLASLPAEWCNIDILVNNAGLALGMEPAHKASIEDWETMIDTNNKGLVYMTRAVLPGMVERNHGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLNLRTDLHGTAVRVTDIEPGLVGGTEFSNVRFKGDDGKAEKTYQNTVALTPEDVSEAVWWVSTLPAHVNINTLEMMPVTQSYAGLNVHRQ
What is the function of this protein?
NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids.  Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone.  Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate.  Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid.  YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde.
What are the official names of this protein?
NADP-dependent 3-hydroxy acid dehydrogenase YdfG, L-allo-threonine dehydrogenase, Malonic semialdehyde reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MASTR_HUMAN
Sequence: MTLAASSQRSQIIRSKFRSVLQLRIHRRNQEQISDPDPWISASDPPLAPALPSGTAPFLFSPGVLLPEPEYCPPWRSPKKESPKISQRWRESKPRGNLTYHQYMPPEPRQGSRADPQAEGSALGPPGPSLWEGTDSQQPHPRMKPSPLTPCPPGVPSPSPPPHKLELQTLKLEELTVSELRQQLRLRGLPVSGTKSMLLERMRGGAPPRERPKPRREDSPAGAPWPRLKPKALAAARRQGSVKPSAASHRPPLPRAADTPGTAPAPTPTPAPAAAPALTPSSGPGSAALTLEEELQEAIRRAQLLPNRGIDDILEDQVEPDDPLPPIPLDFPGSFDVLSPSPDSEGLSSVFSSSLPSPTNSSSPSPRDPTDSLDWLEALSGGPPLGSGPPPPSIFSADLSDSSSSRLWDLLEDPW
What is the function of this protein?
Transcriptional coactivator.  Stimulates the transcriptional activity of MEF2C.  Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity).
What are the official names of this protein?
MEF2-activating motif and SAP domain-containing transcriptional regulator, MEF2-activating SAP transcriptional regulatory protein.
What are the subcellular locations of this protein?
Nucleus.