PharMolix/UniProtQA huggingface dataset:
Protein: TRMD_CORDI
Sequence: MRLDVITIFPEYLDPLRHALLGKAIEKDLLSVGVHDLRLWAEDAHKSVDDSPFGGGPGMVMKPTVWGPALDDVATMSGKAHMGAQLDSARVHVDKPRHDELEGIQFAGYDAAEVAEADKPLLLVPTPAGAPFTQEDARAWSNEEHIVFACGRYEGIDQRVIEDAKKTYRVREVSIGDYVLIGGEVAVLVIAEAVVRLIPGVLGNTQSHQDDSFSDGLLEGPSYTKPREWRGLEVPEVLTSGNHAKIERWRREQSLKRTWEVRPELLDGMELDRHDQAYVEGLRRGNTSDNLN
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHOX1_ARATH
Sequence: MGKPTGKKKNNNYTEMPPTESSTTGGGKTGKSFDRSATKSFDDDMTIFINRALELKEEGNKLFQKRDYEGAMFRYDKAVKLLPRDHGDVAYLRTSMASCYMQMGLGEYPNAINECNLALEASPRFSKALLKRARCYEALNKLDFAFRDSRVVLNMEPENVSANEIFERVKKVLVGKGIDVDEMEKNLVNVQPVGAARLRKIVKERLRKKKKKSMTMTNGGNDGERKSVEAVVEDAKVDNGEEVDSGRKGKAIEEKKLEDKVAVMDKEVIASEIKEDATVTRTVKLVHGDDIRWAQLPLDSSVVLVRDVIKDRFPALKGFLIKYRDSEGDLVTITTTDELRLAASTREKLGSFRLYIAEVSPNQEPTYDVIDNDESTDKFAKGSSSVADNGSVGDFVESEKASTSLEHWIFQFAQLFKNHVGFDSDSYLELHNLGMKLYTEAMEDIVTGEDAQELFDIAADKFQEMAALAMFNWGNVHMSKARRQIYFPEDGSRETILEKVEAGFEWAKNEYNKAAEKYEGAVKIKSDFYEALLALGQQQFEQAKLCWYHALSGEVDIESDASQDVLKLYNKAEESMEKGMQIWEEMEERRLNGISNFDKHKELLQKLGLDGIFSEASDEESAEQTANMSSQINLLWGSLLYERSIVEYKLGLPTWDECLEVAVEKFELAGASATDIAVMVKNHCSSDNALEGMGFKIDEIVQAWNEMYDAKRWQIGVPSFRLEPLFRRRSPKLHDILENVFSGPQ
What is the function of this protein?
Carboxylate clamp type tetratricopeptide repeat protein that may act as a potential Hsp90/Hsp70 co-chaperone (PubMed:20856808).  Contributes to polar growth of root hairs (PubMed:28096376).
What are the official names of this protein?
Protein PHOX1, Protein MADB1, Putative myosin adapter B1.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein.
Protein: SNG3_HUMAN
Sequence: MEGASFGAGRAGAALDPVSFARRPQTLLRVASWVFSIAVFGPIVNEGYVNTDSGPELRCVFNGNAGACRFGVALGLGAFLACAAFLLLDVRFQQISSVRDRRRAVLLDLGFSGLWSFLWFVGFCFLTNQWQRTAPGPATTQAGDAARAAIAFSFFSILSWVALTVKALQRFRLGTDMSLFATEQLSTGASQAYPGYPVGSGVEGTETYQSPPFTETLDTSPKGYQVPAY
What is the function of this protein?
May play a role in regulated exocytosis.  May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal.
What are the official names of this protein?
Synaptogyrin-3.
What is the protein family that this protein belongs to?
Belongs to the synaptogyrin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Synapse. Note=Found at the neuromuscular synapses.
Protein: Y051_RICPR
Sequence: MLKKIIFGITISLTTGCFANSTASNLSKKDVAKTNDVNTQKIIDDFSVYAGTIKPEVREEIQKYRVEIVDINKKKRELYNRLSKEAQSFLAEQQKYKQKLSIPKLLIENDPKNNTANSKDNNDKDMK
What are the official names of this protein?
Uncharacterized lipoprotein RP051.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ACHB_CHICK
Sequence: APTVALLLLCALCSAADAPPPPPSAAASADGAYHAGVRPAPTPRDRVEVRVGLSLAQLVSLDEKNEELTTKVYLDLSWWDPRLQWDPHDYGGLGGLRVAASRLWLPDIGLDNNNDGEF
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: CHST3_MOUSE
Sequence: MEKGLALPQDFRDLVHSLKIRGRYVLFLAFVVIVFIFIEKENKIISRVSDKLKQIPHFVADANSTDPALLLSENASLLSLSELDSTFSHLRSRLHNLSLQLGVEPAMESQEAGAEKPSQQAGAGTRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVFFQQRGASAAGSALVYRDVLKQLLLCDLYVLEPFISPPPEDHLTQFLFRRGSSRSLCEDPVCTPFVKKVFEKYHCRNRRCGPLNVTLAGEACRRKDHVALKAVRIRQLEFLQPLVEDPRLDLRVIQLVRDPRAVLASRIVAFAGKYENWKKWLSEGQDQLSEDEVQRLRGNCESIRLSAELGLRQPAWLRGRYMLVRYEDVARRPLQKAREMYSFAGIPLTPQVEDWIQKNTQATRDSSDVYSTQKNSSEQFEKWRFSMPFKLAQVVQAACGPTMHLFGYKLARDAASLTNRSISLLEERGTFWVT
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin (PubMed:9597547, PubMed:11696535).  Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (PubMed:9597547).  Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (PubMed:11696535).  Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity).  May play a role in the maintenance of naive T-lymphocytes in the spleen (PubMed:11696535).
What are the official names of this protein?
Carbohydrate sulfotransferase 3, Chondroitin 6-O-sulfotransferase 1, C6ST-1, Chondroitin 6-sulfotransferase, C6ST, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0, GST-0.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: Y1994_EXIS2
Sequence: MSTEIGTVHRQRALELLEADSHKIRRLIEVQLANLTMPQCPLYEEVLDTQMFGLSRQIDFAVRLELIDASEGKQLLDSLEQQLSDLHDAETC
What are the official names of this protein?
UPF0358 protein Exig_1994.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.
Protein: DXR_GEOMG
Sequence: MKKLTILGSTGSIGTSTLEIVAAHPDRFQVIALTAGSNLELLKQQVEVFRPRLVSVLTADLARQLDRMLSDPKPEIHHGIPGLIAAATAGEADVVVAAIVGAAGLVPTAAAIKAGKDVALANKETLVTAGRIMMDLVRENGVRLYPVDSEHSAVFQSLEGQSGKDVKRIILTASGGPFLNLPLDRLSRVSVADALNHPNWSMGQKITIDSATMMNKGLEVIEARWLFDTPAERIAVNIHPQSIIHSMVEYVDGCVMAQLGVPDMKAPIAYALTYPERIPTGVKPLDLTALSGLTFLAPDYQRFPALKLAYDALAAGESMPAVMNAANEVAVEAFLKGKIGFTGIATSIARTMDAHEPHTLATIEDVLSSDLWAREKSRELIGLS
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: NAA20_MACFA
Sequence: MTTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE
What is the function of this protein?
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln.  Proteins with cell cycle functions are overrepresented in the pool of NatB substrates.  Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
What are the official names of this protein?
N-alpha-acetyltransferase 20, Methionine N-acetyltransferase, N-acetyltransferase 5, N-terminal acetyltransferase B complex catalytic subunit NAA20, N-terminal acetyltransferase B complex catalytic subunit NAT5, NatB complex subunit NAT5, NatB catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ARD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GRB14_HUMAN
Sequence: MTTSLQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADRRKKKDLDVPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPTNYGFCFKPNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL
What is the function of this protein?
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways.  Binds to, and suppresses signals from, the activated insulin receptor (INSR).  Potent inhibitor of insulin-stimulated MAPK3 phosphorylation.  Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
What are the official names of this protein?
Growth factor receptor-bound protein 14, GRB14 adapter protein.
What is the protein family that this protein belongs to?
Belongs to the GRB7/10/14 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
Protein: RPOB_BIFLS
Sequence: MATESTTNTTTIIARADQHDIDLHKASDRVNFGSIKEPIDVPYLLGVQTDSFDWLIGSDRWKARVEEDEKNGTNTVAHTSGLDEVFNEISPIENFAQTMSLTFSDPYFEEPRHTVQECKEKDYTYSAPLYVNAEFENGDTGEIKSQTVFMGDFPLQTPHGTFIIGGTERVIVSQLVRSPGVYFDRQQDRTSDKEVFGAKIIPSRGAWLEFEIDKKDQPQVRVDRKRKQSAIVFLMAIGMTKSEIAQAFKDYPLVLDALEKETLETQDEALVDLYRKIRPADTPTPEAGKNLLDSFYFNTKRYDLARVGRYKINRKLGVEADFNDRSLHQEDIIATIKYLVALHDGAATFPGKRNGEDVDLRVDVDDIDHFGNRRIRQVGELIQNQLRTGLSRMERVVRERMTTQDAEAITPQSLINIRPVNATIKEFFGTSQLSQFMDQNNPLSGVTNKRRLSALGPGGLSRDRASMEVRDVHPSHFGRMCPIESPEGPNIGLIGSLATFGRVNPFGFIETPYRKVVNGHVTDEVEYMTADRDLDHVIAQANQELDENGNFVSKSALARVGEEEAVDVPVSSVDYMDVSPRQMVSLGASLIPFLEHDEGHRALMGTNMQRQAVPLIESERPLVGTGSEWRAANDSGDVIKSEKDGVVTYVSADLIRVMNDDGTTSSYKLAKFQRSNQTTCYNQRPIIHDGERVEAGSVLADGPAIQKGDLALGKNLLIAFMPWNGYNYEDAVIISQRLVQDDTLSSIHIEEYEIDARETKLGAEEITRDLPNVGEDAVANLDERGIIRIGAEVEAGDILVGKVTPKGETELTPEERLLRAIFGEKSREVRDTSLRVPHGETGTVIGVKEITREDAEEDGDELPNGVNQMIRVYIAQHRKITVGDKLSGRHGNKGCISRILPEEDMPFLADGTPVDIMLNPLGVPSRMNLGQVLELHLGWIAHSGWDISLDPNMEAEWKKLVPSGAEKAEPNTPVATPVFDGVKPEVLKGLLSTTLPNRDGDRLVGPDGKATLFDGRTGEPYTKPISVGYMYMLKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLHEMMTTKSDDVDGRVRVYGAIVKGDNLPPAGIPESFKVLLKEMQSLSLNVEVLNAEGVAIDMKDEDDDPASSADDLGFNIGARPDAAAKEDQKAEEPEYQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: SST2_YEAST
Sequence: MVDKNRTLHELSSKNFSRTPNGLIFTNDLKTVYSIFLICLDLKEKKHSSDTKSFLLTAFTKHFHFTFTYQEAIKAMGQLELKVDMNTTCINVSYNIKPSLARHLLTLFMSSKLLHTPQDRTRGEPKEKVLFQPTPKGVAVLQKYVRDIGLKTMPDILLSSFNSMKLFTFERSSVTDSIIHSDYLIHILFIKMMGAKPNVWSPTNADDPLPCLSSLLEYTNNDDTFTFEKSKPEQGWQAQIGNIDINDLERVSPLAHRFFTNPDSESHTQYYVSNAGIRLFENKTFGTSKKIVIKYTFTTKAIWQWIMDCTDIMHVKEAVSLAALFLKTGLIVPVLLQPSRTDKKKFQISRSSFFTLSKRGWDLVSWTGCKSNNIRAPNGSTIDLDFTLRGHMTVRDEKKTLDDSEGFSQDMLISSSNLNKLDYVLTDPGMRYLFRRHLEKELCVENLDVFIEIKRFLKKMTILKKLIDSKHCDKKSNTSTSKNNIVKTIDSALMKQANECLEMAYHIYSSYIMIGSPYQLNIHHNLRQNISDIMLHPHSPLSEHFPTNLYDPSPASAESAASSISSTEADTLGEPPEVSLKPSKNLSNENCSFKKQGFKHQLKEYKPAPLTLAETHSPNASVENSHTIVRYGMDNTQNDTKSVESFPATLKVLRKLYPLFEIVSNEMYRLMNNDSFQKFTQSDVYKDASALIEIQEKC
What is the function of this protein?
Desensitization to alpha-factor pheromone.  Is involved in regulating the signaling pathway for responding to mating pheromone.
What are the official names of this protein?
Protein SST2.
Protein: CLPS_ECOL5
Sequence: MGKTNDWLDFDQLAEEKVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RR7_GUIAB
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIHGVTPGIAVKARRVGGSTHQVPIEIGSTQGKALAIRWLLAASRKRPGRNMAFKLSSELVDAAKGSGDAIRKREETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y2906_CAUVC
Sequence: MTLQPFDGFGLGLRPPHYRAFLDSERPLVDFVEVISENFMVGGGRPLHVIDAVRERYPVALHGVSMSVGSADGVKLDYLRRLKGLADRVDPMWVSDHLCWTGVEGFNSHDLLPVPYTEEAMAVVCANIALAQDVLERPLLLENPSSYVTFANDAMAEHQFLAEMCARTGCYLLLDINNIYVSASNHGFDPYEYLAAVPVDRVLQIHLAGHSQGRELLIDTHDQPVPDSVWALYEAAAGRFGPVAAMIERDDDIPPLDDLLAELDVARARWAAGRRGSLAA
What are the official names of this protein?
UPF0276 protein CC_2906.
What is the protein family that this protein belongs to?
Belongs to the UPF0276 family.
Protein: U79B9_ARATH
Sequence: MGQNFHAFMFPWFAFGHMTPYLHLANKLAAKGHRVTFLLPKKAQKQLEHHNLFPDRIIFHSLTIPHVDGLPAGAETASDIPISLGKFLTAAMDLTRDQVEAAVRALRPDLIFFDTAYWVPEMAKEHRVKSVIYFVISANSIAHELVPGGELGVPPPGYPSSKVLYRGHDAHALLTFSIFYERLHYRITTGLKNCDFISIRTCKEIEGKFCDYIERQYQRKVLLTGPMLPEPDNSRPLEDRWNHWLNQFKPGSVIYCALGSQITLEKDQFQELCLGMELTGLPFLVAVKPPKGAKTIQEALPEGFEERVKNHGVVWGEWVQQPLILAHPSVGCFVTHCGFGSMWESLVSDCQIVLLPYLCDQILNTRLMSEELEVSVEVKREETGWFSKESLSVAITSVMDKDSELGNLVRRNHAKLKEVLVSPGLLTGYTDEFVETLQNIVNDTNLE
What are the official names of this protein?
UDP-glycosyltransferase 79B9.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: DDR1_HUMAN
Sequence: MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV
What is the function of this protein?
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation.  Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases.  Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing.  Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation.  Required for normal ear morphology and normal hearing (By similarity).  Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing.  Also plays a role in tumor cell invasion.  Phosphorylates PTPN11.
What are the official names of this protein?
Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, MCK-10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, Tyrosine-protein kinase CAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Secreted. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
Protein: METL4_HUMAN
Sequence: MSVVHQLSAGWLLDHLSFINKINYQLHQHHEPCCRKKEFTTSVHFESLQMDSVSSSGVCAAFIASDSSTKPENDDGGNYEMFTRKFVFRPELFDVTKPYITPAVHKECQQSNEKEDLMNGVKKEISISIIGKKRKRCVVFNQGELDAMEYHTKIRELILDGSLQLIQEGLKSGFLYPLFEKQDKGSKPITLPLDACSLSELCEMAKHLPSLNEMEHQTLQLVEEDTSVTEQDLFLRVVENNSSFTKVITLMGQKYLLPPKSSFLLSDISCMQPLLNYRKTFDVIVIDPPWQNKSVKRSNRYSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRFIKEELYPSWSVEVVAEWHWVKITNSGEFVFPLDSPHKKPYEGLILGRVQEKTALPLRNADVNVLPIPDHKLIVSVPCTLHSHKPPLAEVLKDYIKPDGEYLELFARNLQPGWTSWGNEVLKFQHVDYFIAVESGS
What is the function of this protein?
N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:31913360, PubMed:32183942).  Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (PubMed:31913360).  Internal m6A(m) methylation of snRNAs regulates RNA splicing (PubMed:31913360).  Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:32183942).  The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo (PubMed:32203414).  Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending (PubMed:32183942).  N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity).
What are the official names of this protein?
N(6)-adenine-specific methyltransferase METTL4, Methyltransferase-like protein 4, N(6)-adenine-specific DNA methyltransferase METTL4, snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Mitochondrion matrix.
Protein: IF2_METCA
Sequence: MSDVTVRQLAGIVGIPLDRLLHQLGDAGLQISDADDVLSDAEKMKLLNHLRQSHGKVQESVTEPKRVTLQRRSVTELKQGTVPGKGAKTISVEVRKKRTYVKRSELPETSDRLSEAEQARRALEEQQQRELAEQEARRQQEEMLREQAAEEERRRQEEAARTAEERRRRDEEERQAAAERETVAAKPAPVAAPPIPRPAPEPRPPARPSAGKPKAEAPRAHPAERETEARGDKRSAGLSRKDEYRELQGDDFRKGGGKRKKPKTGRPMLMPEQKHGFEKPTAPIVYEVAVPESITVSDLAQRMSVKGVEVIKALMKMGVMATINQVLDQETAILVVEEMGHKAIAQKEDDLEAEIMANLAAEAEAPQLPRPPVVTIMGHVDHGKTSLLDYIRKSRVAAGEAGGITQHIGAYQVKTDHGSITFLDTPGHAAFTAMRARGAKVTDIVVLVVAADDGVMPQTREAVEHSRAAGVPLVVAMNKMDKADADPDRVKQELVGLNVVPEEWGGDVQFVPVSAKTGAGIDTLLDAILVQAEVLELKAPVAIPAAGVVLESKLEKGRGPVADILIQRGTLKKGDFLLCGKEIGRVRAMFNENGKPLKEAGPSAPIEVLGLSGAPEAGDEFIVVADERKAREIALHREEKLRSTKLAAQQAAKLEDVFSLMGSEETIDLNLVIKADVQGSLEALRSALTELSTDKVKVRVIGGGVGGISETDANLALASNAILIGFNVRADGSARKLIEERGIDLHYYSVIYNAIDEVKKSINGMLEPEFKEQIIGIAQVREVFRSSKFGTVAGCLVVEGHVRRNLPIRVLRDNVVIFEGQLESLRRFKDDVNEVKSGMECGIAVRNYNDVREGDQIEVFEKVQVAPH
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUB_ORPSP
Sequence: MKSIISIAALSVLGLISKTMAAPAPAPVPGTAWNGSHDVMDFNYHESNRFEMSNWPNGEMFNCRWTPNNDKFENGKLKLTIDRDGSGYTCGEYRTKNYYGYGMFQVNMKPIKNPGVVSSFFTYTGPSDGTKWDEIDIEFLGYDTTKVQFNYYTNGQGHHEHIHYLGFDASQGFHTYGFFWARNSITWYVDGTAVYTAYDNIPDTPGKIMMNAWNGIGVDDWLRPFNGRTNISAYYDWVSYDAPRN
What are the official names of this protein?
Beta-glucanase, 1,3-1,4-beta-D-glucan 4-glucanohydrolase, Endo-beta-1,3-1,4 glucanase, Lichenase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MANB_CALM0
Sequence: MKVYKKVAFVMAFIMFFSVLPTISMSSEANGAALSNPNANQTTKNVYSWLANLPNKSNKRVVSGHFGGYSDSTLAWIKQCARELTGKMPGILSCDYKNWQTRLYVADQISYGCNQELINFWNQGGLVTISVHMPNPGFHSGENYKTILPTSQFQNLTNHRTTEGRRWKDMLDKMADGLDELQNNGVTVLFRPLHEMNGEWFWWGAEGYNQFDQTRANAYISAWRDMYQYFTHERKLNNLIWVYSPDVYRDHVTSYYPGANYVDIVALDSYHPDPHSLTDQYNRMIALDKPFAFAEIGPPESMAGSFDYSNYIQAIKQKYPRTVYFLAWNDKWSPHNNRGAWDLFNDSWVVNRGEIDYGQSNPATVLYDFENNTLSWSGCEFTDGGPWTSNEWSANGTQSLKADVVLGNNSYHLQKTVNRNLSSFKNLEIKVSHSSWGNVGSGMTARVFVKTGSAWRWNAGEFCQFAGKRTTALSIDLTKVSNLHDVREIGVEYKAPANSNGKTAIYLDHVTVR
What is the function of this protein?
Could be involved in the degradation of glucomannan and catalyzes the endo hydrolysis of beta-1,4-linked mannan, galactomannan and glucomannan.
What are the official names of this protein?
Mannan endo-1,4-beta-mannosidase A and B, 1,4-beta-D-mannan mannanohydrolase, Beta-mannanase, Endo-1,4-mannanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 26 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMC_SHEFN
Sequence: MKCDYFERGDCLSCRNIQLPMVEQVSVKQQQLIDLFRGISVKQWLAPILSAESGFRNKAKMVVLGAAHKPILGLVNPKGEPVSLCDCSLYPKDMQLLLHRLERFVQQAGIPPYRVDKSKGELKFILLTRSQSSGQFMLRFVLRSDQAIVRIERELPQLLQEFPEITLVSANIQPIHMAILEGEREIFLTETTRLEEQLNNVPLFIRPKSFFQTNPEVAAQLYQIAREWVTEFKPNYIWDLFCGVGGFGLHCADSNIRLTGIEIESEAIECAILSATKLGFTQVDFSALDSTHFAKGQSAQDKPDLIIVNPPRRGLGKSLCDSLSEFAPKAIVYSSCNPHTLMSDLEYITGYQITKVQMFDMFPHTDHFEVLVMLEQL
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: TATA_RICRO
Sequence: MGMSFSHLLIVLLIIFVLFGAGKLPQVMSDLAKGLKAFKDGMKDDGSDNDKNK
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.