PharMolix/UniProtQA huggingface dataset:
Protein: APOE_MACFA
Sequence: MKVLWAALLVTFLAGCQAKVEQPVEPETEPELRQQAEGQSGQPWELALGRFWDYLRWVQTLSEQVQEELLSPQVTQELTTLMDETMKELKAYKSELEEQLSPVAEETRARLSKELQAAQARLGADMEDVRSRLVQYRSEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLASQPLQERAQALGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQISLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGASTAPVPIDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: CSEPA_MELLP
Sequence: MMSQRYFKLLVVFLGLFAMIASIAEGKGRHKNGGGSRKKTNTVNNGGNNGGKPKVPMCGTTAATCSKGSPSCKGGKPTCGSKGAFNACGGNVKVTC
What is the function of this protein?
Rust effector delivered into infected tissues to modulate host functions and contribute to pathogen virulence (PubMed:30283062).  Binds the TGA1a-binding DNA sequence to repress the expression of genes involved in immune responses such as the defense-related transcription factors WRKY18, WRKY27, WRKY33, MYB51, the defense-related proteins NHL3, RPP8, YLS9, AZI1, CRK11 and the jasmonate pathway and regulation genes JAZ1, ASA1, ASB1.  Other genes involved in diverse mechanisms also down-regulated include the chitinase CHI, the brassinosteroid-related genes BAS1, BES1 PAR1, BEE1, the salicylic acid-related gene NPR3, the ethylene-related response genes ARGOS and ARGOS-like (ARL), EBF2, ERF6, ETR2, RTE1, the carbon metabolism-related gene EXO, as well as the red/far red light signalization-related genes FAR1, GA2OX2, PAR1, PIF3, PKS4 (PubMed:30283062).
What are the official names of this protein?
Candidate secreted effector protein MPL124478, CSEP MPL124478, Small secreted protein MPL124478, SSP MPL124478.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host nucleus, host nucleolus.
Protein: RSMG_XANOR
Sequence: MNDAALAPDVSAALERGLQAQSLDTAFAAPLLRYLALLVRWNKTYNLTAVRDPRAMVTRHLLDSLAMQPYIASGMLADLGTGPGLPGIPLAITRPQLQVTLVESNGKKARFMREALRHLELRNARVAESRAEALDEPTAYDHLTARALDTLAGIIAVGGHLLRPGGSLLAMKGIYPHEEIAALPEGWTMSEVHQLQVPGLDGERHLVVVRKA
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITPA_YEAST
Sequence: MSNNEIVFVTGNANKLKEVQSILTQEVDNNNKTIHLINEALDLEELQDTDLNAIALAKGKQAVAALGKGKPVFVEDTALRFDEFNGLPGAYIKWFLKSMGLEKIVKMLEPFENKNAEAVTTICFADSRGEYHFFQGITRGKIVPSRGPTTFGWDSIFEPFDSHGLTYAEMSKDAKNAISHRGKAFAQFKEYLYQNDF
What is the function of this protein?
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives.  Xanthosine 5'-triphosphate (XTP) is also a potential substrate.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Hydroxylaminopurine sensitivity protein 1, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYA_RHOBA
Sequence: MKTDELREKYLAFFETKGCVRQPSDVLVPAWDPSVLFTPAGMNQFKDHFLGKVKLDFTRATTCQKCLRTGDIDNVGRTAFHHTFFEMLGNFSFGDYFKEEAIHWAWEFLTDKKWLGIPGERLTVTVYKDDDEAFGIWHDKIGLPTQRISRMDEDENFWPASAPSEGPDGVCGPCSEIYYQLEDGSDVEIWNLVFTQFNRVGTPPDNLHPLPSKNIDTGMGLERTASVLQGVPTNFHIDSLFPIVEAASEVCGVKYEYESDNGRRLRRITDHARASVFAVHENVYPGPKDARSVIRRLIRRAVLDGYQMNLREPFLYKLVEAVADASKAAYPELGQTTQRVSEAIESEEKAFFSTIDGGMKRIHRLFEEMNDEASVMVPGAEAADLLTTYGVPPELVQTLAAEQNFTFDWSGFREAMDKHADESDGGQRVLFQTGPLETLKEALRETPFVGYEQTEATAVVKGIITGDGKGKGDDGQLLSHLDRPEDAVLRLVLDHSPFYGESGGQVGDIGVISNDNFEFEVIDTQRHASMIVHHGRLIRGKINEGETCTAKVDVENRTALARAHSATHILHHALHTHVGRHAEQQGSKVEPDRLRFDFTNPKAIDDETLVKIEQDVLGMVGKGDEIRWDTVSLADAREAGAMMLFGEKYPDPCRMVSMGTFSRELCGGTHLTNTKQVGSFEVVVEESVSTGTRRIEALTGERAKEHREQTQALLNEVAGKLNCDASVAAAATVALIEEVRRLKKELSSGKAADYPAEFVFDAKAAKAETTDISDYNAVRAAVRGLTRRLNVAITDVLSRLDSLLADRSKLVEQLKQVTAGGKISADDLIADGTKVGDTLLIVAETPGANPNIMRGWIDQIRKKSDTPTAVLLASSMNDKVMLVGGLSRDLVDRGLKAGDWVGAAAKVVGGSGGGRPDMAQAGGKDASKLPEALQQARETMTEKLG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBL_METEZ
Sequence: MSLLKLCKGDLLTRVLATGTFDLLHPGHLHYLSEARKLGNELYVIVARESMIKHKPKPVIPENQRVTMVNSLDVVDKAVLGSETNIYEPIKNIKPDVITIGYDQKFSSDSIEKNLEELGINAKVVRINKLSDCSLCSSGKIIDRILERYC
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.
Protein: CBPYA_MAGO7
Sequence: MRIATSTLLVGAASAAFAPQDGTQRVLNGFDSIKSAAHSIQKPLQTFEEAMASMTSEAKANWDHLKLLVPDAEEQAKTFFPKKPKPASRKPDSAWDHIVKGADIQAMWVEGATPEETHRKIDGKLDNYNLRARSVDPSKLGVDTVKQYSGYLDDEANDKHLFYWFFESRNDPKNDPVVLWLNGGPGCSSLTGLLFELGPGAINAKIEIVHNPYAWNNNASVIFLDQPVNVGYSYSGGSVSNTVAAGKDIYALLTLFFHQFPEYAKQDFHIAGESYAGHYIPVFASEILSHKKRNINLKSVLIGNGLTDGLTQYEYYRPMACGEGGWKAVLSESECQAMDNALPRCQSMIQNCYDSGSVWSCVPASIYCNNAMIGPYQRTGRNVYDIRGPCKDSGNLCYPELGYISEYLNRREVMEALGAEVSSYDSCNFDINRNFLFQGDWMQPYHRLVPELLNQIPVLIYAGDADFICNWLGNQGWTEALEWKGKKDYNRADYSPLTLASAHDVKPYGKVKSSGNFTFMKIFEAGHMVPYDQAEPSVDFVNRWLAGEWFAA
What is the function of this protein?
Vacuolar carboxypeptidase involved in degradation of small peptides.  Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).
What are the official names of this protein?
Carboxypeptidase Y homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: TRMA_ACTSZ
Sequence: MQQLPIEKYDELLAEKCRKLTALLAPFDAPALTVFPSPTQHFRMRAEFRLWHDYSENRGGNLYHIMFDKTTKQRYRVDQFPVASQLINRMMATILPLLKEQDVLSRKLFQIDYLSTLSEQIIVSLLYHKTLTDEWQEAAQALKVRLRNLGFSVQIIGRATKQKICLDQDFVDEELSVGDKKYVYRQVENSFTQPNAALNCKMLEWAIDCTRDSQGDLLELYCGNGNFSIALAQNFRKVLATEIAKPSVAAAQFNIAANQVDNLQIIRMSAEEFTQAVNGVRAFNRLKGIDLQAYECHTIFVDPPRAGLDSDTVKLVQKYDRILYISCNPQTLCENLQILSQTHRIERAALFDQFPYTEHMEAGVWLMRK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: METN_RHIEC
Sequence: MNSVVTRAAIEPRPQAAAEEVVRLIDVKRRFGATPALDGISLNVNRGEILGIIGRSGAGKSTLIRCLNGLERADSGEIRIEGRDITGLQEQELQPLRGRIGMIFQHFNLLSAKTVEDNVALPLKIEGIAKAERLQRAHELLEVVGLADKAQAYPASLSGGQKQRVGIARALAARPALLLSDEATSALDPETTRSILALLRDINRKLGLTILLITHEMEVVRGIADRVAVIDAGRIVEEGQVWSVFANPQTDITRSLLGGIRPQLPDHILSRLSATTGSEVILSVDLAGPEAQGALFAELSAALPHSFRLVHGGIDHIQNQPVARFFIAVPAHEPALAGKVEQFLTARSARVEVLGYDTGHA
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HSCA_CUPNH
Sequence: MALLQISEPGMSPAPHQRRLAVGIDLGTTNSLVAAVRSSIPEVLGDERGRALLPSVVRYLPDRTAHIGYRAQEEAVRDPKNTIVSVKRFMGRGLRDVANIEHSPYDFVDAPGMLQIKTAAGVKSPVEISAEILATLRQRAEDTLGDDLVGAVITVPAYFDEAQRQATKDAARLAGLEVLRLLNEPTAAAIAYGLDNASEGIYAVYDLGGGTFDISVLKLTQGVFEVLATGGDSALGGDDFDQRLLCWIVEQASLQPLSAQDMRLLMVRARAAKEALSESDSTVIDAVLESGEIVHLTLTVEIFDQVTAHLVQKTLAPVRKALRDAGVAPDEVKGVVLVGGATRMPSIRKAVGDYFGQTPLTNLDPDRVVALGAAMQANLLAGNHAPGEDWLLLDVIPLSLGVETMGGLVEKIIPRNSTIPVARAQEFTTFKDGQTAMAIHVLQGERELASDCRSLARFELRGIPPMVAGAARIRVTYQVDADGLLSVTARETHSGVEASVTVKPSYGLADDDIARMLQESFREAEHDMKSRALAEERVEADRLVEATQRALETDGDLLSAEERTAVEALMATVREIATGEDHHAIHAAVEKLSHGTDEFAARRMDRSIKSALAGRKVQELG
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: Y6048_DICDI
Sequence: MESMNNQEILNGTIEYVSRSSKLLKKVSDITKEKIKDYPYLDDLTEEYIQAQHLYDRTPKLLKLLSEINITDAIISNEVIENINNMKYELDHLIESTQFRIDDIDTYFKRVETEYFLKDKKNEFYVELSSYNSQIQDSLKKLKSIYDGGKLLTKEVSEINRKKFKNSDKVLTKHINTGIALFIILTSLLVYFIQFKPKISQD
What are the official names of this protein?
Putative uncharacterized transmembrane protein DDB_G0288997.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RAB14_PIG
Sequence: MATTPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
What is the function of this protein?
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development.  Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.  May act by modulating the kinesin KIF16B-cargo association to endosomes.  Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity).
What are the official names of this protein?
Ras-related protein Rab-14.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or M.tuberculosis.
Protein: SCX5C_CENLI
Sequence: MNSLLMITACLVLFGTVWAKEGYLVNKSTGCKYGCFWLGKNENCDMECKAKNQGGSYGYCYSFACWCEGLPDSTPTYPLPNKSCSKK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Toxin Cll5c.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CUTA_YERPB
Sequence: MSDSDAMTDPNAVSYSNAIVVLCTAPDEASAQNLAAQVLGEKLAACVTLLPGATSLYYWEGKLEQEYEVQLLFKSNTDHQQALLTYIKQHHPYQTPELLVLPVRDGDKDYLSWLNASLL
What is the function of this protein?
Involved in resistance toward heavy metals.
What are the official names of this protein?
Divalent-cation tolerance protein CutA.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLK_SALHS
Sequence: MTKYALVGDVGGTNARLALCDIASGEISQAKTYSGLDYPSLEAVVRVYLDEHSVSVEDGCIAIACPITGDWVAMTNHTWAFSIAEMKKNLGFSHLEIINDFTAVSMAIPMLKKEHLIQFGGGEPVDGKPIAVYGAGTGLGVAHLVHVDKRWISLPGEGGHVDFAPNSEEEAMILEILRAEIGHVSAERVLSGPGLVNLYRAIVKSDNRLPENLRPKDITERALADNCIDCRRALSLFCVIMGRFGGDLALTMGTYGGVYIAGGIVPRFLEFFKASGFRGGFEDKGRFKDYVHGIPVYLIVHDNPGLLGSGAHLRQTLGHIL
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRC40_MOUSE
Sequence: MSRHMRAPRFDPRAGFHAEGKDRGPSVPQGLLKAARSSGQLNLAGRNLGEVPQCVWRINVDIPEEANQNLSFSSTERWWDQTDLTKLIISSNKLQSLSDDLRLLPALTVLDIHDNQLTSLPSAIRELDNLQKLNVSHNKLKILPEEITSLKNLRTLHLQHNELTCIPEGFEHLSCLEDLDLSSNRLATVPADFALLSSLLRLNLSSNQLKNLPAEISRMKRLKHLDCDANLLETVPPDVGSMESLELLYLRRNKLRVLPEFPSCRQLKELHLAENQIEKLGAEHLQHLQAILVLDLRGNKLRSVPEEMALLQSLERLDLSNNDISSLPCSLGNLHLKFLALEGNPLRTIRREIIAKGTQEVLKYLRSKIKDDRTNQNDSVPETAMTLPSEARVNIHAIATLKLLDYSDKQATLIPDDLFDATKTTLITSINFSKNQLCEIPQRIVELKEMVLDINLSFNKLSFISHELCLLQKLTFLDLRNNFLSSLPEEMSSLTKLQTINLSFNRFKVFPEVLYRISTLEAVLISNNQVGSVDPQKMKLMENLNTLDLQNNDLLQIPPELGNCVQLRTLLLDGNPFRVPRAAILMKGTAAVLEYLRDRIPA
What are the official names of this protein?
Leucine-rich repeat-containing protein 40.
Protein: FEM1A_BOVIN
Sequence: MDLHTAVYNAARDGKLQLLQKLLSGRSREELEELTGEVASGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGEIIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCNARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPAGDEQAQPGLARVQPQGARSSPEEPPSGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRSAKGSLGTPIGFADLMGVLCKGVREVERALQLPKEPGDSAQFTKALAIILHLLYLLEKVECTPDQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDAETTNVGRYPVGRFPSLQVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPGIMNALIEAGAHMDATNAFKKTAYELLDEKLLAKSTIQPFNYVTLQCLAARALDKNKIPYKGFIPEELEAFIELH
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity).  Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4.  Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity).
What are the official names of this protein?
Protein fem-1 homolog A, FEM1a, FEM1-alpha.
What is the protein family that this protein belongs to?
Belongs to the fem-1 family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: RUVC_PROMA
Sequence: MVILGIDPGLARVGYGLIEVNNQRQVKMLDCGIIKTNKNQYEGERMVEIAKDLRVLIRKWKPGLAAVEKFFFYKSSTTISVVQARGVLIMTLARFKVPIVEFPPMQIKLAVAGSGHAKKDEVLEAVMRELRLKVPPRPDDAADALAIALTGLFQQ
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: GUX3_ARATH
Sequence: MIPSSSPMESRHRLSFSNEKTSRRRFQRIEKGVKFNTLKLVLICIMLGALFTIYRFRYPPLQIPEIPTSFGLTTDPRYVATAEINWNHMSNLVEKHVFGRSEYQGIGLINLNDNEIDRFKEVTKSDCDHVALHLDYAAKNITWESLYPEWIDEVEEFEVPTCPSLPLIQIPGKPRIDLVIAKLPCDKSGKWSRDVARLHLQLAAARVAASSKGLHNVHVILVSDCFPIPNLFTGQELVARQGNIWLYKPNLHQLRQKLQLPVGSCELSVPLQAKDNFYSAGAKKEAYATILHSAQFYVCGAIAAAQSIRMSGSTRDLVILVDETISEYHKSGLVAAGWKIQMFQRIRNPNAVPNAYNEWNYSKFRLWQLTEYSKIIFIDADMLILRNIDFLFEFPEISATGNNATLFNSGLMVVEPSNSTFQLLMDNINEVVSYNGGDQGYLNEIFTWWHRIPKHMNFLKHFWEGDEPEIKKMKTSLFGADPPILYVLHYLGYNKPWLCFRDYDCNWNVDIFQEFASDEAHKTWWRVHDAMPENLHKFCLLRSKQKAQLEWDRRQAEKGNYKDGHWKIKIKDKRLKTCFEDFCFWESMLWHWGETNSTNNSSTTTTSSPPHKTALPSL
What is the function of this protein?
May be involved in the substitutions of the xylan backbone in stem glucuronoxylan.
What are the official names of this protein?
Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 3, UDP-GlcA:xylan glucuronyltransferase 3, Glycogenin-like protein 3, Plant glycogenin-like starch initiation protein 2, Protein GLUCURONIC ACID SUBSTITUTION OF XYLAN 3, AtGUX3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: CH1B1_MOUSE
Sequence: MSNMEKHLFNLKFAAKELNRSSKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQGVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKSMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
What is the function of this protein?
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis.  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.  Involved in cytokinesis.  Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 1B1, Chromatin-modifying protein 1b-1, CHMP1b-1.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endosome. Late endosome membrane; Peripheral membrane protein. Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body (By similarity).
Protein: ARCA_STRPY
Sequence: MTAQTPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQALRDEGIEVLYLETLAAESLVTPEIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQELIEKTMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHMFSETRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRVYSVTYDNEELHIVEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIAPGVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI
What is the function of this protein?
Antitumor protein.  Has a powerful and dose-dependent inhibitory effect on antigen, superantigen, or mitogen-stimulated human peripheral blood mononuclear cell (PBMC) proliferation.  It may inhibit cell proliferation by arresting cell cycle and inducing apoptosis (By similarity).
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD, Streptococcal acid glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.