PharMolix/UniProtQA huggingface dataset:
Protein: SSC14_ARATH
Sequence: MFYSQFILAKKGPLGTIWIAAHLERKLRKNQVADTDIGVSVDSILFPEAPIALRLSSHLLLGVVRIYSRKVNYLFDDCSEALLKVKQAFRSAAVDLPPEESTAPYHSITLPETFDLDDFELPDNEIFQGNYVDHHVSTKEQITLQDTMDGVVYSTSQFGLDERFGDGDTSQAALDLDEAVFQDKDVIGSDDEGVPGIDHNAYLDAAAPGIKDSMEGVSEAMPMDFNEEQVEDLAMNNEFIEDAQAPQTPGLVEVPNSSSVREQMACDDHMDVEDLNAEEGIKSSGELNANEMPKRGEDLSSEYNAPESAVTPVEVDKSQIDENVNTQNEPEEERAEHVHVTSPCCSHITTEMEDPGQVMNEAGANVVPDKPDAVPPLETPGEENRDHFAIATEVNQETDSSLQGDEQAYSRPDGQLNNAHETDEQLGNLTGFTDSDFPPPEKVLAVPNRQGDGNDFMVESTPDKEDPGTCNDDAGNNNITGKKRTFTESTLTAESLNSVESVGLIQSKRTADSVPDDDDLLSSILVGKSSFLKMRPTPVLEPATTKRLRSAPRSTATKRKVLMDDPMVLHGDIIRQQLTNTEDIRRVRKKAPCTVPEIVMLQRQALEDGLFKEPIFTGMSVELVSLHTEPYDLRGIMIIENDDRHASVGAVEDNECSVTAVEENKTEESSDPQAHPNDCEEQPGTAHTHPQEEQTINQQEELKDDNELAEKSDLEVLKEGNGAADEVNLVVIDDVSQIPSEEKLDRVEDLQVEESHENHDGEGGQDVCADPNEKSCTDVIEIAEGDTDINPIFNEMDLKVEDELPHEDEKTDASAEVSELGRDDQTPCDNTVGSTETGCLEAGDLSNMALENCNEPLVEANSDGLNPETESYNKYEPHNEMSNEEASMQNALDGEHTSRDGLMGDNDEMDTMENAHDTGFLNVDDDEVDEDHEEDDIQYDDETRLLENSGWSSRTRAVAKYLQTLFDKETENGKNVLVADKLLAGKTRKEASRMFFETLVLKTRDYIQVEQGKPYESIIIKPRPKLTKSIF
What is the function of this protein?
Involved in sister chromatid and centromere cohesion during mitosis.
What are the official names of this protein?
Sister chromatid cohesion 1 protein 4, AtRAD21-3, AtRAD21.3.
What is the protein family that this protein belongs to?
Belongs to the rad21 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere.
Protein: ACCA_HELPG
Sequence: MAIYLDFENHIKEIQNEIELALIRGDEDAKEILEKRLDKEVKSIYSNLTDFQKLQLARHPDRPYAMDYIDLILKDKYEVFGDRHYNDDKAIVCFIGKIDNIPVVVIGEEKGRGTKNKLLRNFGMPNPCGYRKALKMAKFAEKFNLPILMLVDTAGAYPGIGAEERGQSEAIAKNLQEFASLKVPTISVIIGEGGSGGALAIAVADKLAMMEYSIFSVISPEGCAAILWDDPSKTEVAIKAMKITPRDLKEAGLIDDIILEPSKGAHRDKFSAANTIKEYFLDALRTIQQDPHFLDNRYQKLMSLGSFVESMN
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_CAUVN
Sequence: MKIAEIRGMTPDQLADTLISLKKEQFNLRFQAATGQVEKTHRVNEIRKDIARIKTVLRAKAAA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: TRPF_BRUSI
Sequence: MALDIKICGLKTPEAVAAALDGGATHIGFIFFPKSPRHITPDAAARLRAAATGRAVAVAVTVDADDEALDEIVKTVRPDMLQLHGGETPERVRFLKERYNLPVMKAFSIREAGDLEAIAPYRGIADRFLFDAKPPKGSELPGGNGISFDWNLLAALDADIDYMLSGGLNADNIAEALLKTGAPGIDISSGVECAPGEKDVRLIENFFQAVADANAQPFARRA
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: VP4_ROTHY
Sequence: MASLIYRQLLTNSYTVNLSDEIQEIGSTKTQNTTINPGPFAQTGYAPVNWGPGETNDSTTIEPVLDGPYQPTSFNPPVGYWMLLSPTTAGVIVEGTNNTDRWLATILIEPNVTSQQRTYTIFGVQEQITIENTSQTQWRFVDVSKTTQNGSYSQYGPLLSTPKLYAVMKYGGRIHTYSGQTPNATTGYYSATNYDSVNMTTFCDFYIIPRSEESKCTEYINNGLPPIQNTRNIVPLALSARNVIPLKAQSNEDIVVSKTSLWKEMQYNRDITIRFKFANSIVKSGGLGYKWSEISFKPANYQYTYMRDGEEVTAHTTCSVNGMNDFSFNGGSLPTDFVISRYEVIKENSYVYIDYWDDSQAFRNMVYVRSLAANLNSVTCAGGDYNFALPVGQWPYMTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLAVEEPSFAIMRTRVSGLYGLPAANPNNGREYYEIAGRFSLISLVPSNDNYQTPIANSVTVRQDLERQLGELREEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSIATNVMKKFKRSSLASSVSTLTDSLSDAASSVSRGSSIRSVGSSVSAWTDVSIQITDVSSSVSSISTQTSTISRRLRLKEMATQTEGMNFDDISAAVLKTKIDKSIQISPTTLPDIVTEASEKFIPNRAYRVINNDEVFEAGTDGRFFAYRVDTFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGIGKQQAFNLLRSDPRVLREFINQNNPIIRNRIEQLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: COBA1_MOUSE
Sequence: MEPWSRWKTKRWIWDLTISTLALTFLFQAREVRGAAPVDILKALDFHNSPVGISKTTGFCTNRKNSKDPDVAYRVTEEAQISAPTKQLFPGGIFPQDFSILFTIKPKKGTQAFLLSLYNEHGIQQLGVEVGRSPVFLFEDHTGKPTPENYPLFSTVNIADGKWHRVAISVEKKTVTMIVDCKKKITKPLDRSERSIVDTNGIMVFGTRILETDVFQGDIQQFLITGDPKAAYDYCDHYSPDCDLTSKAAQAQEPHIDEYAPEDIIEYDYEYGETDYKEAESVTEMPTFTEETVAQTEANIVDDFQDYNYGTMEPYQTETPRRVSGSNEPNPVEEGFTEEYLTGEDYDVQRNTSEDILYGNKGVDGRDSDLLVDGDLGEYDFYEYKEYEERTTTSPNEEFGPGVPAETDFTETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGLMGPPGLQGPSGLPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSAGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGESGSKGDRGFDGLPGLPGDKGHRGERGPQGPPGLPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGPPGQPGIGGIDGPQGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQVGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGIAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPAGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGIRGFPGERGLPGAQGAPGLKGGEGPQGPQGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGLPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSIGSVGVVGDKGEPGEAGNPGPPGEAGSGGLKGERGEKGEAGPPGAAGPAGIKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGASGSEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPSGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPLGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPIGPPGPPGLPGPAGPKGNKGSSGPTGQKGDSGMPGPPGPPGPPGEVIQPLPILSPKKTRRHTESIQGDAGDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTAGGETCIYPDKKSEGVRISSWPKEKPGSWYSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYNCHQSAAWYDVLSGSYDKALRFLGSNDEEMSYENNPHIKALYDGCASRKGYEKTVIEINTPKIDQVPIIDVMINDFGDQNQKFGFEVGPACFLG
What is the function of this protein?
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
What are the official names of this protein?
Collagen alpha-1(XI) chain.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PAX6_DANRE
Sequence: MPQKEYYNRATWESGVASMMQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYEKLRMLNGQTGTWGTRPGWYPGTSVPGQPNQDGCQQSDGGGENTNSISSNGEDSDETQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNSSSHIPISSSFSTSVYQPIPQPTTPVSFTSGSMLGRSDTALTNTYSALPPMPSFTMANNLPMQPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQAHMNSQSMAASGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
What is the function of this protein?
Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development.
What are the official names of this protein?
Paired box protein Pax-6, Pax[Zf-a].
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KAD_FRATO
Sequence: MRIILLGAPGAGKGTQAKIIEQKYNIAHISTGDMIRETIKSGSVLGQELKKVLDAGELVSDEFIIKIVKDRISKNDCNNGFLLDGVPRTIPQAQELDKLGVNIDYIVEVDVADNLLIERITGRRIHPASGRTYHTKFNPPKVADKDDVTGEPLITRTDDNEDTVKQRLSVYHAQTAKLIDFYRNFSSTNTKIPKYIKINGDQAVEKVSQDIFDQLNKR
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_STAAW
Sequence: MKKKALLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGSNKKGKNTQVVSKKKKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2550_CLOB1
Sequence: MDMKKLIERINFLYKKSKEEGLTKEEKVEQQKLRREYTDIIKGNVKVQLEGVEKIPTPNRKN
What are the official names of this protein?
UPF0291 protein CLB_2550.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_HALLT
Sequence: MADTIQEAVTLALDDAPERNFRETVDIAINLRDLDLNDPSNRIDESVVLPAGTGQETQIVVFAEGETAVRAQEVADQVLDSDDLEDLGDDDDRAKDLADETDFFVAEANLMQDIGRYLGTVLGPRGKMPTPLQPDDDIVDTVNRMKNTVQLRSRDRRTFHTRVGAEDMGPDAISDNIDVIIRRLEASLEKGPLNIDGIYVKTTMGPAKEVPV
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: GATB_SACD2
Sequence: MEWETVIGLEVHVQLATKTKIFSGASTAFGAEPNTQACAIDLAMPGTLPSPNAKAFEYAIMFGLAVNAEIGKRSVFERKNYFYPDSPKGYQTTQLEQPIVGAGYIDIELDDGSTKRIRIHHAHLEEDAGKSLHEDFHDMTGIDLNRAGTPLIEVVTEPDISNKAEAVAFARKLHAIVTSLGIGDGDMSQGSMRFDVNISVRLKGQELGTRTETKNLNSFRFMERCIDQEVQRQIEVLEDGGKITQETRLYNGDTHTARPMRSKEEANDYRYFPCPDLLPVEITDEYIQSLRDKLPELPDARKARFIEQYGLSDYDAGLLGSDANTAHYFEVCAKACDDAKLSANWVAGELAARLNNEELAIQNSPVNAEQLAGLIARIKDQTISNKIAKQVFEAMWQGEGDADTVIEAKGLKQVSDSGALEKMVDDVMAANQQQVDAYRAAEPDKRKKMLGFFVGQIMKASKGQANPQQLNQILLSKLDS
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: IF2A_XENTR
Sequence: MPALSCRFYQHKFPEVDDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKDKGYIDLSKRRVSPEEALKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLYQRTAWVFDEKYKKPGYGAYDAFKHAVSDPDVLDGLDLNEDERRVLIDNINRRLTPQAVKIRADIEVACYGYEGIDAVKDALRAGLSCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMSVIKERIEEKRGVFNVQMEPKVVTDTDETELARQLERLEKENAEVDGDDDAEEMEAKTED
What is the function of this protein?
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.  This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex.  Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.  EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1.
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-alpha family.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule.
Protein: RNPH_BEII9
Sequence: MRPSKRAAQDLRPVTLERNVARYAEGSCLVKFGGTHVLCTASLEDKPPPWLRGQGRGWVTAEYAMLPRATHTRTRRESMSGKPSGRTQEIQRLIGRSLRAVTNLPALGERQITLDCDVLQADGGTRTAAITGAWVALHDCCKWMHGRSIIKEFPLREHVAAVSCGIYQGEAVLDLDYEEDSVAQTDANFVMTGGGALVEVQASAEGAVFSEDELSVLLALAKGGIAQLVNIQKLAIG
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: NORM_PSEPK
Sequence: MHVAPTTELKALLRLAGPLIASQLAHMLMVLTDTLMMARISPQALAGGGLGAASYSFVSIFCLGVIAAVGTLVAIRKGANDIEGATRLAQNGLWLAWALALFAALVLWNLEPVLLLFGQKPENVASAAEFLTLLPLALPGYLTFMALRGFTSALGRSTPVMVISLFGTVLNYLFNVALIEGMFGLPKLGLMGIGLVTAVVSMGMATALALYIRWHPAYTAYPLRKGLSRPSLAALRELWRLGLPIGGTYMVEVGLFAFAALCMGVLGSTELAAHQIALQIVSTAFMVPTGLSYAVTMRVGLYYGAGNLLAARSAGRVGIGFGAMIMFAFATLFLLLPEALVGLFIDRNDPAFAAIFQVAVQLLMVAAWFELFDGMQTIAMGSIRGLKDAKTTFLIGLVCYWLVGAPSAWLFTFTLGGGAVGIWWGLALGLACAAVALTFGFEWRMKRLLGKAGVRTEAAVSA
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CPGP2_ZINOF
Sequence: DDLPDSIDWRENGAVVPVKNQGGCGSCWAFSTVAAVEGINQIVTGDLISLSEQQLVDCTTANHGCRGGWMNPAFQFIVNNGGINSEETYPYRGQDGICNSTVNAPVVSIDSYENVPSHNEQSLQKAVANQPVSVTMDAAGRDFQLYRSGIFTGSCNISANHALTVVGYGTENDKDFWIVKNSWGKNWGESGYIRAERNIENPDGKCGITRFASYPVKKGTN
What is the function of this protein?
Cysteine proteinase with a specific activity toward peptides with a proline residue at the P2 position.
What are the official names of this protein?
Zingipain-2, Cysteine proteinase GP-II.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: TVA24_HUMAN
Sequence: MEKNPLAAPLLILWFHLDCVSSILNVEQSPQSLHVQEGDSTNFTCSFPSSNFYALHWYRWETAKSPEALFVMTLNGDEKKKGRISATLNTKEGYSYLYIKGSQPEDSATYLCAF
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 24.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RL7_MESHJ
Sequence: MAKITKEQFIESLKEMTIKEVMEFVDALKEEFGVDPSAVAVAATPVATEEVKTEVKLTLKAAGQQKVAVIKVVKDLLGLSLMDAKKLVDAAPSVLKEAIKPEEAEEYKAKLVAAGAEVSID
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: GPC3_PANTR
Sequence: MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASKELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVARVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSVPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMMKVKNQLRFLAELAYDLDVDDAPGSNQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH
What is the function of this protein?
Cell surface proteoglycan (By similarity).  Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity).  Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity).  Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity).  Positively regulates the non-canonical Wnt signaling pathway (By similarity).  Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity).  Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity).  Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity).  Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity).  Required for coronary vascular development (By similarity).  Plays a role in regulating cell movements during gastrulation (By similarity).
What are the official names of this protein?
Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7.
What is the protein family that this protein belongs to?
Belongs to the glypican family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Protein: SELO_BORA1
Sequence: MMLSKLDALTLDNSFAALPDTFYTRLAAQPLGRPRLLHANAEAAALIGLDPAELHTQAFLEVASGQRPLPGGDTLAAVYSGHQFGVWAGQLGDGRAHLLGEVRGPGGSWELQLKGAGLTPYSRMGDGRAVLRSSVREYLASEAMHGLGIPTTRALALVVSDDPVMRETRETAAIVTRMSPSFVRFGSFEHWSSRRDGERLRILADYVIDRFYPQCREANGEHGDVLALLREVSQRTAHLMADWQSVGFCHGVMNTDNMSILGLTLDYGPFGFMDAFQLGHVCNHSDSEGRYAWNRQPSVALWNLYRLGGSLHGLVPDADALRGVLAEYETLFTQAFHARMGAKLGLSVWQSDDEALLDDLLRLMHDSRADFTLTFRALAQAVRGQTQPFLDYFIDREAAQAWWSRLAARHACDGRAAAVRAEGMDRVNPLYVLRNHLAEQAIRAAQQGDASEIDRLLGLLRRPYDLQPGAEAYAALPPDWAAGLSVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: LSPA_FRATT
Sequence: MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSLKITSFFNLTLLYNHGAAFSLLSNDQTSWQMIMFSTISLIAAIVLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYVIDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKKS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLP1_DICDI
Sequence: MSNDNSVNINNFSSMNGGGGGSDIQFPLKPSQQQQQQQQNSINQSTIRTLEITQELRYEIDFDQNGWMKLIEGTAECFGTELSLNKVYKLSGTKGAVFTWTGCKIEITNNCQPYIGEKTPMPQYAGVYQELDAFRVSILDEPKKSGPRVIIVGPTDSGKSSLSKILLAYSARSGYQPLFVDLDPGQGSITIPGTISAAHIQNPLDIEEGLAGGIPLAHFYGHTSLDVNPDLFKALCKNLASFIDKQLDSSNISRISGFIANTCGWIDGLGYKILLQNIDVFKANLIIVMDNEKLYSDISSHYSQKDNSIKIIKLPKSGGVFIRPPVFRKKTRMNRIKEYFNGINDNLSPHYIVLDFKDVSIYRTGGGPAAPASALPIGTSSQIDPLQITEVYPSLDMCHSIFAISYAKQASNIFHSNVAGFLYVSDIDMETKKITVISPAPGPLPSRFLLLGTLKWMEN
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
Protein CLP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.