PharMolix/UniProtQA huggingface dataset:
Protein: SAPM_MYCTU
Sequence: MLRGIQALSRPLTRVYRALAVIGVLAASLLASWVGAVPQVGLAASALPTFAHVVIVVEENRSQAAIIGNKSAPFINSLAANGAMMAQAFAETHPSEPNYLALFAGNTFGLTKNTCPVNGGALPNLGSELLSAGYTFMGFAEDLPAVGSTVCSAGKYARKHVPWVNFSNVPTTLSVPFSAFPKPQNYPGLPTVSFVIPNADNDMHDGSIAQGDAWLNRHLSAYANWAKTNNSLLVVTWDEDDGSSRNQIPTVFYGAHVRPGTYNETISHYNVLSTLEQIYGLPKTGYATNAPPITDIWGD
What is the function of this protein?
Virulence factor that plays an important role in blocking phagosome-lysosome fusion and thus participates in the intracellular survival of the pathogen (PubMed:15753315, PubMed:23923000).  Acts as a phosphatase that dephosphorylates phosphatidylinositol 3-phosphate (PI3P), a membrane trafficking regulatory lipid essential for phagosomal acquisition of lysosomal constituents (PubMed:15753315).  Therefore, SapM eliminates PI3P from the phagosomal membrane by catalyzing its hydrolysis, and thus contributes to inhibition of phagosome maturation (PubMed:15753315).  Also interferes with autophagy: SapM blocks autophagosome-lysosome fusion in macrophages by binding to the small GTPase RAB7, which prevents RAB7 from being involved in this process and thus negatively regulates autophagy flux (PubMed:25896765).  In vitro, displays phosphatase activity with broad specificity; can dephosphorylate a variety of phosphoester substrates, with the highest activity against phosphoenolpyruvate, glycerophosphate, GTP, NADPH, phosphotyrosine and trehalose-6-phosphate (PubMed:11073936).  In contrast, the enzyme exhibits poor activity against glucose-6-phosphate, phosphothreonine, and a number of nucleotides (NADP, ATP, AMP, and GMP) (PubMed:11073936).
What are the official names of this protein?
Phosphatidylinositol-3-phosphatase, PI3P phosphatase, Acid phosphatase SapM, Secreted acid phosphatase.
What are the subcellular locations of this protein?
Secreted. Host cytoplasmic vesicle, host phagosome. Note=It remains to be determined how SapM, once secreted into the phagosomal lumen, gains access to PI3P within the cytofacial membrane leaflet. It is possible that SapM is exported to the cytosolic side, or alternatively there may be a mechanism for PI3P presentation to SapM remaining on the luminal side.
Protein: RL14_ECOK1
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MINE_CUPMC
Sequence: MSILSFLLGEKKKSASVAKERLQIILAHERSGHSAPADYLPALQRELVAVISKYVKISDQDLRVSLERQDNLEVLEVKIEIPQA
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RSMH_STAAC
Sequence: MFHHISVMLNETIDYLNVKENGVYIDCTLGGAGHALYLLNQLNDDGRLIAIDQDQTAIDNAKEVLKDHLHRVTFVHSNFRELTQILKDLNIEKVDGIYYDLGVSSPQLDIPERGFSYHHDATLDMRMDQTQELTAYEIVNNWSYEALVKIFYRYGEEKFSKQIARRIEAHREQQPITTTLELVDIIKEGIPAKARRKGGHPAKRVFQALRIAVNDELSAFEDSIEQAIELVKVDGRISVITFHSLEDRLCKQVFQEYEKGPEVPRGLPVIPEAYTPKLKRVNRKPITATEEDLDDNNRARSAKLRVAEILK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYPX_TRYBB
Sequence: MSGLAKYLPGATNLLSKSGEVSLGSLVGKTVFLYFSASWCPPCRGFTPVLAEFYEKHHVAKNFEVVLISWDENESDFHDYYGKMPWLALPFDQRSTVSELGKTFGVESIPTLITINADTGAIIGTQARTRVIEDPDGANFPWPN
What is the function of this protein?
Acts as a thiol-disulfide oxidoreductase.  It is spontaneously reduced by trypanothione.
What are the official names of this protein?
Tryparedoxin, TryX.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: CEDA_SALNS
Sequence: MMKPLRQQNRQIISYIPRVEPAPPEHAIKMDTFRDVWILRGKYVAFVLTGESFQRSPAFSVPESAQRWANQVRQENEIAD
What is the function of this protein?
Activates the cell division inhibited by chromosomal DNA over-replication.
What are the official names of this protein?
Cell division activator CedA.
What is the protein family that this protein belongs to?
Belongs to the CedA family.
Protein: ORCH_CRYCV
Sequence: MNKVFIIGVCLFIVSQAVLAVPWDSDESSDERLSDRSDESREEPRKLVVSDDDSREDSNESAEVRRRDDSRESEEEPRKLSADTSDEDSDDSQESPLDLFFKTLRDSKISRAQRAALLKALLSRYAGY
What is the function of this protein?
Plays a role in cuticle calcification.  May induce precipitation of the calcium stored in the posterior caeca as calcium carbonate.
What are the official names of this protein?
Orchestin.
What are the subcellular locations of this protein?
Secreted. Note=During the premolt period, localizes to microvilli-rich apical regions and to the subnuclear region. During the postmolt period, localizes to the intercellular space, basal region of cells and calcium reabsorption spherules.
Protein: CHSE4_MYCTU
Sequence: MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFLTINSVAPTIMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSATYYSDVRVPVANRVGEENAGWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGGTRLIDSEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGTELATEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGMVALGLPRANR
What is the function of this protein?
Involved in the first cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism (PubMed:26161441).  It contributes partly to the virulence by increasing the efficiency of beta-oxidation.  Catalyzes the dehydrogenation of acyl-CoA ester side chains of (25S)-3-oxo-cholest-4-en-26-oyl-CoA (3-OCS-CoA) to yield (24E)-3-oxo-cholest-4,24-dien-26-oyl-CoA (PubMed:26348625, PubMed:26161441).  Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) as well as 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) (PubMed:26161441).  It dehydrogenates only (25S)-OCS-CoA diastereomer (Probable).
What are the official names of this protein?
Acyl-CoA dehydrogenase FadE26, ACAD, 3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
Protein: GPDA_EHRRU
Sequence: MKISILGAGSFGTAIAIALSAHGISVNLWGRDHRNITHINTYRKNLKYLPTYHLPDNIYATSNIDEVLSDNNTCIILTIPTQQLRTICTQIQHKQHMCKNTPILICSKGIEITSLKFPSEIAEEILQYNPIFILSGPSFAKEIAEHLPCSIVLAGDNKELGESLIETISNDVLKIIYHQDIIGVQIGAALKNIIAIACGIIAGKNLGNNAVATVITKGMNEIKTLYIAKNHSIDLHTLIGPSCLGDLILTCTTEHSRNMAFGLEIGKGRNINTLIDHNLKLVEGTSTVKPLISLAKKLNVELPICISIYNLLHENISLDKAISNILS
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_MYCMM
Sequence: MTVLCVTGTCTGVGKTVVTAALASQANQAGIDVVVCKPVQTGTGIGDDDLAEIGRLSGVTELVGLARYPLPMAPVAAAEQAGQPLPSRDQLVQHIRGLDRPGRLTLVEGAGGLLVELADSGGTLRDLAVDLGAAMLVVVAAGLGTLNHTALTLEALAAQKVSCAGLVLGSWPAHPGLVESSNRDALARLAPMRAVLSAGAAQLSVADFAVMSAGAFDREWVATLVG
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AOXA_MACFA
Sequence: MDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITNRIRHHPANACLIPICSLYGTAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPGMVMSIYTLLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCETSGCCQSKENGVCCLDQRINGLPEFEEGSKTSPKLFAEEEFLPLDPTQELIFPPELMIMAEKQPQRTRVFGSERMMWFSPVTLKELLEFKFKYPQAPVIMGNTSVGPQMKFKGVFHPVIISPDRIEELSVVNHTHNGLTLGAGLSLAQVKDILADVVQKLPGEKTQTYHALLKHLGTLAGSQIRNMASLGGHIISRHPDSDLNPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSRKLEFVSAFRQAQRQENALAIVNSGMRVFFGEGHGIIRELSISYGGVGPATICAKNSCQKLIGRHWNEEMLDTACRLVLEEVSLSGSAPGGRVEFKRTLIISFLFKFYLEVSQILKKMDPIRYPSLADKHESALEDLHSKHHCSTLKYQHMGPKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDVITAEHLSDVNSFCFFTEAEEFLATDKVFCVGQLVCAVLADSEVQAKRAAKQVKIVYQDLEPLILTIKEAIQHNSFFEPERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVASTLKLPANKVMCHVKRVGGAFGGKAFKTGVIAAVTAFAANKHGRAVRCVLERGEDMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGNSLDESLLVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAGLITESCIMEVAAKCGLSPEKVRMINMYKEIDQTPYKQEINAKNLIQCWRECMAVSSYSLRKAAVEKFNAENYWKKKGLAMVPLKYPVGLGSRAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELGMPISNVHLRGTSTETVPNANVSGGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESISLSAVGYFRGYESDINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLYTIEELNYSPQGVLHTRGPDQYKIPAICDTPTEFHISLLPPSENSNTLYSSKGLGESGVFLGCSVFFAIHDAVSAARRERGLHGPLSLNSPLTPEKIRMACEDKFTKMIPRDEPGSCVPWNVPI
What is the function of this protein?
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin.  Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents.  Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent.  Is probably involved in the regulation of reactive oxygen species homeostasis.  May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen.  May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor.  May play a role in adipogenesis (By similarity).
What are the official names of this protein?
Aldehyde oxidase 1, Azaheterocycle hydroxylase 1.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_LATSS
Sequence: MTTKGILGRKVGMTQVFTENGELIPVTVIAATPNVVLQVKTNETDGYEAIQVGFEDKREVLSNKPAKGHVAKANTTPKRFIREFRDVALGDYEVGTEIKVDTFAAGDVVDVTGVTKGHGFQGNIKKDGQSRGPMGHGSRYHRRPGSMGAVINRVFKGKLLPGRMGNNQRTVQNLVVVSTDVEKNVILVKGNVPGAKNSMVTIKTAVKAHK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ATPE_BRUME
Sequence: MAQAFQFELVSPERLLLSAQVTEVVIPGSEGYLTALAGHSPLMTTIMPGVVSVKLADGKTDSYVVFGGFADITPQGCTVLAESATHVDDIDPADIQHRIDHARKVLEDASSNEHRTKAEIFLHQLMTLQGAILPA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NUOH_LEGPL
Sequence: MLHTIGILIWIIIKIIVIVVPLLISVAYLTYAERKVIGYIQVRIGPNRVGLKGLLQPFADLLKLITKEIIVPTRSNKYLFVIAPLFALVPSLVGWAVIPFQEGVVLANINAGVLYLFAMSSLGVYGVLIAGWASNSKYAMFGALRSTAQTVSYEIAMGFALVGVLLAAGSMNLTDIVNSQKGGMLHWWFIPLLPLFLVFWISGIAETNRAPFDLAEGESEIVAGFHVEYSGIGFALFFLSEYASMILISTVLAILFMGGWLSPFEGITFLDQIFFIVPGFVWLLLKISFFLFVYLWVRATFPRYRYDQLMRLGWKVLIPVTIVWLIVTAVMVVAHVKPWF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCST_FLAAN
Sequence: MRGGLWQLGQSITRRLGQSDKKTIVRRCYASEADLKKTVLYDFHVAHGGKMVPFAGWSMPIQYKDSIMDSTINCRENGSLFDVSHMCGLSLKGKDCVAFLEKLVVADVAGLAPGTGSLTVFTNEKGGAIDDSVITKVTDDHIYLVVNAGCRDKDLAHIEEHMKAFKAKGGDVSWHIYDERSLLALQGPLAGSTLQHLTKEDLSKMYFGDFRIIDINGSKCFLTRTGYTGEDGFEISVPSENAVDLAKAILEKSEGKVRLTGLGARDSLRLEAGLCLYGNDMEQHITPVEAGLTWAIGKRRRAEGGFLGADVILKQIADGPAIRRVGLFSTGPPARSHSEIQNEKGENIGEVTSGGFSPCLKKNIGMGYVKSGLHKPGTKLKIVIRGKTYEGSVTKMPFVPTKYYKPA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, mitochondrial, Glycine cleavage system T protein, GCVT.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: KAX46_TITST
Sequence: VFINAKCRGSPECLPKCKQAIGKAAGKCMNGKCKCYP
What is the function of this protein?
Blocks potassium channels Kv1. 2/KCNA2 and Kv1. 3/KCNA3 with high affinity (K(d)=1. 9 nM and 10. 7 nM, respectively).  The voltage-dependent steady-state parameters of potassium channel gating are unaffected by the toxin in both channels, but due to the fast association and dissociation kinetics the toxin slows the rate of inactivation of Kv1. 3/KCNA3 channels.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 4.6, Tst26.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 04 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DDL_PARL1
Sequence: MSQAKHVAVLKGGWSAEREVSLVSGKGCAEALRKHGYRVTEIDAGRDLADQILKVKPDVAFNALHGRWGEDGCVQGLLEILRVPYTHSGVLASALAMHKERAKFVFRAAGLPVAESVVVPREQAAHGHVMDPPYVIKPVSEGSSVGVFIVRAGDNRPPAELTSAEWNLGDEVMAERYIAGRELTCAVMGEEIFGVTEIIANTTFYDYEAKYQTGGSRHIIPAPIDADIYAEVQRVTLAAHKALGCRGVSRADFRFDDTRPGKPELILLEVNTQPGMTPTSLVPELANLAGYSYGELVSWMVEEASCDR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_CHLAD
Sequence: MPPLIESVVLQPLIAPIDPGFDGRRSRRIERRSFARIKDAIDLPLLIETQLKSFEWFKREGLRELFDEISPITDFTGKNLELHFREYTFGEPRYDEFECRDRDLTYAAPLRVKVELRILTTGEIKESEIFLGDFPMMTDNGTFVYNGAERVVVSQLIRSPGVYFKDEKDPTSGRALHTAKLIPNRGAWLEFETNKRDVISVKVDRKRKIPVTILLRAISAWIANEDGSGRWAPDNELDKYGHNEHLIELFRHVDTVAEHLYIQATIDKDPSHNAKEALLELYKRLRPGDPPTLENARTLIESLLFNPRRYDLAKVGRYKLNKNLWERDARRDGPKAPDLSVRVLLPRDIFRIVEQMILLNNGYGRPDDIDHLGNRRVRTVGELIQQQFRVGLLRLERVVKERMSLQDPASATPNGLINIRPVVAAMREFFGGSQLSQFMDQTNPLAELTNKRRLSALGPGGLSRDRAGFEVRDVHHSHYGRICPVETPEGPNIGLIGTMSTFARVNEMGFLETPYRKVYNSIDNAQVWREKGILLRDVRDLRTGDLIAAKGTRVDDQIARQITIGLLRGQILREDVVDPNTGELIAEAGTEINRALAERIVNLPMKQIKIRPVVSQEVDYLSADEEDRFVIVQANAPLDEHNRFLDTTVSCRFGEDFVTERVERVDYMDVSPKQVVSVSTSLIPFLEHDDANRALMGSNMQRQAVPLLRPDAPIVGTGMEYRTARDSGQVVVARRDGVVVSATGNRIIVEEDDGKRTEYRLRKFMRSNQDTCINQRPSVVRGQQVRAGDVIADSSSTDQGELALGQNVLVAYMPWEGGNFEDAILVSERLVREDIFTSIHIEKYEVEARDTKLGPEEITRDIPNVGQDSLRNLDERGIIYIGAEVQPNDILVGKITPKGETDLTAEERLLRAIFGEKAREVKDSSLRVPNGVRGKVIDVKVFSRSEGAELPVGVNQTVRVLLCQKRKISAGDKMAGRHGNKGVVSRVLPMEDMPFLPDGRPVDIILNPIGVPSRMNIGQILETHLGWAAARLGFRVATPVFDGAHEDQIKDLLVQAGLPADGKVTLYDGRTGEKFDHPVTVGYAYMLKLAHLVEDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRVKTYEAIVKGEPIQEAGVPESFKVLIKELQSLGLSVEVLSADEKPVELSDDLDSDIGALEGINLSGMERGEF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RBL_DUNTE
Sequence: MVPQTETKTGAGFKAGVKDYRLTYYTPDYVVSETDILAAFRMTPQPGVPPEECDAAVAAESSTGTWTTVWTDGLTSLDKYKGRCYDLEPVPGEENQYIAYVAYPIDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRISPAYVKTFVGPPHGIQVERDKLNKYGRGLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEAIYKSQAETGEIKGHYLNATAGTAEGMLQRAQCAKELGVPIIMHDYLTGGFTANTSLAHYCRDHGLLLHIHRAMHAVIDRQRNHGIHFRVLAKTLRMSGGDHLHSGTVVGKLEGEREVTLGFVDLMRDNFVEKDRSRGIYFTQDWCSMPGVMPVASGGIHVWHMPALVEIFGDDACLQFGGGTLGHPWGNAPGAVANRVALEACTQARNEGRDLAREGGNVIRSACKWSPELAAACEVWKEIKFEFDTIDKL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PNP_SOLUE
Sequence: MHHIVEVDLGDRKITLETGKMAKQANGAVVVRSGDAVVLVTACMADQPKPSAGFFPLTVDYREYTYAAGKIPGGFIKREGRLSEKEVLTCRLIDRPIRPLFPEGFMNETQIIAMVLSADPEQDPNSLAIVGTAAALAISDIPFQYVMAGVRVGMRDGQYTANPTYTEGRASKLNIVVAGTEEGIVMVEAGAQEVSEAEVLGAIEFGHECCKKIAAGIRQLMKLCGKTKREFVSPVLDETIYAEVEKQARVDLTDALNTEKHEKLASYALVASVKKRTIEALPDEQKEQGAKCFDALKERIFRDDMLKKHRRPDGREFDQIRQITIETGVLPRVHGSTLFTRGETQALVTVTLGTKDDEQRIELLEPGEASKRFMLHYNFPPFSVGEVGFMRGAGRREIGHGALAERALTALIPGEDKFPYTMRVVSDTLESNGSSSMAAICGGSLALMQAGVPMTAHVGGVAMGLVMEGKDYAILTDIAGAEDHYGDMDFKVAGTRDGITGMQMDIKVPNITTAIMKEALEQARRGRLFILDKMYEAMPQANTAISQYAPRIYTLHIPTDKIRDVIGPGGKVIRGIIEQTGVKIDVEDDGTIHVASADEASANKAIQIISDLTATAEIGKTYLGKVVRLVDFGAFVEIFPGTDGLLHISEIAENRIKDVRDELKEGDQILVKCLALEGNKIKLSRKAVLKEQREKMKQGKE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECE_VIBAL
Sequence: MKANNAETPDSSNAADTFKWLAAFVLAAAAVVGNYLYGEMSVVVRAAGVVVLIAAALGVAATTTKGKAAISFAKESRMEVRKVVWPTRQETMQTTLIVLAVSIVMALVLWGIDGIMVRLVALATGV
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TSSC4_DANRE
Sequence: MSDRKRKGNDAPNSLSNRDTVELPDDLSLSDSDSDEPLESFGRKIEDLSSSSEEEGETRQQVQSVLQENPSFRLTGGSSSFCDRSRDIFAQLDSAAKLTSKDLGEDNILDGTLARPAPPSPPHAVQNKCGVGQELTKKQPPGKKLPDYLAHPERWTHYSLEDIDETSDKKNSQVAHEYIRELQDSKRSQKAALETFTPAFNQDHGSSNENKIVFAKPKSKDQSGSRADHAKKEEVGLQHLDDRVEADEGEALQQSSSWPNKEKKRKWGVTKEEDDTVAPSAVFTSSKRVNRKNFRKTPDDNDGDKE
What are the official names of this protein?
Protein TSSC4.
What is the protein family that this protein belongs to?
Belongs to the TSSC4 family.
Protein: HP1B3_HUMAN
Sequence: MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRETPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATSSEAEQPKGEPENEEKEENKSSEETKKDEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSFRVKK
What is the function of this protein?
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416).  Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
What are the official names of this protein?
Heterochromatin protein 1-binding protein 3, Protein HP1-BP74.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S).
Protein: SYL_CLOBH
Sequence: MGNYSTKIDEKWQKKWEENSLYKFNNKNLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDSWARFKRMQGYNVFQPMGFDAFGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNWENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPSCNTVLANEQVLDGKCERCDSNVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVTFNVADSDLSFNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREKTGVFSGSYAINPINGKKVPIWIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVIEGGDSLPYTEYGGMVNSGEFDGLLGNEAKEAVISKLESMNLGRKKINYRLRDWLVSRQRYWGAPIPIIYCEKCGTVEVPIEQLPVELPYNVEFSPDGKSPLGKCDDFINTTCPKCGGPAKREADTLDTFVCSSWYYLRYPDNNNEKDAFNPELINKMLPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFDEPFLSLTHQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLMFGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNSKDNKSTMDKDEKELNYVRHHSIKSITEDIDKMQFNTSIARLMEFTNALSKYLGIDAIKNALFLRESIIDFITLLAPFAPHFAEEQWKLIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKESALNNEDIKNSIGDKEIKKVIVIKNRLVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.