PharMolix/UniProtQA huggingface dataset:
Protein: ZDH15_XENLA
Sequence: MLAGCRVALPRGLRCCQRVLSWVPVVIISLVVLWSYYAYVWELCLVTVTNPAEKAAYLLIFHTVFLLFIWTYWKAIFTPPKQPTKKFLLPYAEKERYDNEERPEAQKQIVAEFARKLPVYTRTGSGATRFCDTCQMVKPDRCHHCSVCGMCVLKMDHHCPWVNNCIGYSNYKFFLLFLAYAMLYCLYIGCTVFQYFILYWTDTLSNGRAKFHVLFLLFVALMFFISLMFLFGYHCWLVSLNRTTLEAFSTPVFQSGPDKNGFHLGIRRNLEQVFGKERKLWLIPVFTSLGDGFTYPMRMACESRNPLLAAENQWEDDLTDEESQAYCETSHITVHIEK
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity).  Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity).  May thereby regulate target proteins association and localization to membranes (By similarity).  In the nervous system, probably catalyzes the palmitoylation of synaptic proteins and is involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity).
What are the official names of this protein?
Palmitoyltransferase ZDHHC15, Acyltransferase ZDHHC15, Zinc finger DHHC domain-containing protein 15 homolog, DHHC-15.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Postsynaptic density.
Protein: Y3324_RIPO1
Sequence: MIEVYTEHEQGKKWLEKHKNCCPIFACILGFTATGLIPRISAAGATPEDRKYTAIADAEFLIKGIKSDYQYPLPSLKKGVSPVFITRALVESLNIPIYLFNAGLVYPPPIPHIDLGGIAANCLTTGKALPLTTIRHLFQQGLHWGEKLAINAPNSYLIISECVVGGTTTALAILTGLGIDATGKVNSSHPQCNHQQKSSIVRTGLTQAEFYPILQPIDPFSLVGAVGDPMQIVAAGMAIAASRQTGVLLAGGTQMLAVYALIKAIIHDYQESANLEKIVVGTTRWVAEDPTGDTVGLAQGIGKVSLLATKLSFLTSECPQLRIYEEGYVKEGVGAGGCAIAASLSYGWTQEQLLEAIESLVNAKKELF
What are the official names of this protein?
UPF0284 protein PCC8801_3324.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: KCNG1_RAT
Sequence: MTLLPGDNSDYDYSALSCASDTSFHPAFFPQRQAIKGVFYRRAQRLGPQDDLHQSISLGDRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREDEEEALDSEDQESEGPSTSEGRLSRCMRRLRDMVEKPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVLIRRAQYLIKTKSQLSGMSQDSDILFGSASSDTRDNN
What is the function of this protein?
Potassium channel subunit that does not form functional channels by itself.  Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:8980147).
What are the official names of this protein?
Potassium voltage-gated channel subfamily G member 1, Voltage-gated potassium channel subunit Kv6.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BIOD_MYCA1
Sequence: MTVLVVTGTDTGVGKTVATAALACHARRAGIDVAVCKPVQTGTDDGDDDLAEVARLSGVTELAGLARYPRPLAPVAAAAAAGMALPSREQLLRFIGELDRPGRLTLVEGAGGLLVELGENGVTARDLAVALGAAVLVVVRPALGTLNHTALTLEALAAQGLSCAGLVIGAWPEHPGPVETSNRPALEALAPVRAVLPAGAAALAAAEFEAVSAGAFDRDWVTALAG
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUD_ARCFU
Sequence: MEEKVGIECYITSTPGMGGEIKAEPEDFYVEEIAEFNLSDEGDFLIIRVEKKNWDTLNFARVLSNALGISQKRISFAGTKDKRALTVQYFSIYGVKKEEIERVNLKDAKIEVIGYARRAIQLGDLLGNFFRIRVYGCRDGEIFQETRNELMEKGTPNFFGLQRFGSIRFITHEVGKLILQNNYEEAFWVYVAKPFEGENEEVRKIREILWETRDAKLGLRELPKYLRYERNLLQKLREGKSEEEALLSLPKNLKMMFVHAYQSYIFNRLLSERIRQFGSLKTLEEGDFACYLTFKTRPTFSDCSEVEVNEARVRFLVKERVASLALPLVGYDTKLKGWSRIALDFLSEDNLDLSSFKTKHKEFSSSGSYRPADTLIEHTGLSFTDSTFSFYLPRGCYATVFLREFLKTELS
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: ARLY_METPB
Sequence: MSNRMWGGRFASGPAEIMEEINASIGFDRRLAPQDIRGSLAHVAMLGSRGILPAEDVAAIEAGLKSVEAEIERGEFVFRRELEDIHMAVESRLTEIVGPAAGRLHTARSRNDQVATDMRLWVRDTLDALDAQVADLQRALAETAQKHADTVMPGFTHLQSAQPVTFGHHCLAYVEMLARDRGRFRDARARLNECPLGSAALAGTSFPIDRHATAAALGFDRPTANSLDSVADRDFALESLSAASICAVHLSRFAEELVVWTSAQFGFVRLSDRFTTGSSIMPQKRNPDAAELVRAKAGRIIGALTGLLVVMKGLPLAYSKDMQEDKEGTFDALQSLSLCLAAMAGMVRDLEPVAETLKRAAGSGYATATDLADWLVRELNMPFRQAHHVTGRVVAAASERGIGLEDLSLDAMQAIEPGITQAVFAVLGVENSVASRTSYGGTAPDNVRRQAQAWLERLGPVEK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDRGK_DROPE
Sequence: MDLIILVGIASALLVVILTIFFLQKKKGGTEAKEAAAPPQRGVPLRAQEGVPRRAQIARNQRNRLRQNAPAAAPAAAAALQAADAEGDNDDENPDGDGQRMPQGAVLDEKMGAKKRAKMEAKEQKRLHREQELIDREQRKVKEAKEEAERKQQEDFQEEADRKRAEAERLVKEERERKEHEEYLKMKAGFSVEEEGFEEGDADDQDNLLADFIQYIKDNKVVLLEDLAVAFKLKTQQAIERIQDLQANGTLTGVIDDRGKFIYVSEEELAAVAKFIKQRGRVSIVELAESSNNLINLTPVSAGAGEGSS
What is the function of this protein?
Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins.
What are the official names of this protein?
DDRGK domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the DDRGK1 family.
Protein: ATL38_ARATH
Sequence: MVQPGTEIKASDLTLLVITIILFAIFIVGLASVCFRWTSRQFYSQESINPFTDSDVESRTSITAVRGLDEAIINSFPTFLYSEVKERRIGIGGVECAVCICEFEDHETLRLMPECCHVFHADCVSVWLSDHSTCPLCRVDLCLQPGERSYLNPEPDLVESTNSHLFDGVTWTNRNRPSRSWSTRLSQCRVSQILISRSHSTGHSVVQPLDNLDRFTLRLPEEVRRQLTKKTVDNVAFSQARSSRRGYRSRSAGSERSVFSYQRRMHSFSDCAWSTSCGGEAVAPSKDSRRISVEQSQLDDRV
What are the official names of this protein?
RING-H2 finger protein ATL38, RING-type E3 ubiquitin transferase ATL38.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HRH3_RAT
Sequence: MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
What is the function of this protein?
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system.  Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).
What are the official names of this protein?
Histamine H3 receptor, H3R, HH3R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KGUA_WOLPM
Sequence: MTVKSEGVLLVLSSPSGAGKTTISAKLLEQSTNLVRSVSMTTRKPRPGEINGKDYFFVTEEKFHELCKAGQMLEYAKVFENFYGIPRDFIEQNLSSGISVLLSIDWQGAFHLFKLMRKKVVSVFILPPSMEELRLRLQKRNSDDASEIERRLAEAQKEISKRDKYDYVIINDDIDKSVEEISSILNKERLKKLKEKPSLED
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_HELPH
Sequence: MKILVIQGPNLNMLGHRDPRLYGMVTLDQIHEIMQTFVKQGNLDVELEFFQTNFEGEIIDKIQESVGSDYEGIIINPGAFSHTSIAIADAIMLAGKPVIEVHLTNIQAREEFRKNSYTGAACGGVIMGFGPLGYNMALMAMVNILAEMKAFQEAQKNNPNNPINNQK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: CFT1_ASHGO
Sequence: MNVFDEVINATVVNNSVTGHFTTTLREELIITRTNLLSVLHKDNEGRLVLAYEWKLSGRVHGLSLVPHKSGLGRLAVLTGRGRVSIVRFDAENQTLETESLHYYDAKFEELSALTVGAAPRLEQEPAARCLLVHNGDCLAVLPLRGHEEEGEEAEEEEEHPAKRARTDADGRLVGASTVMPASHLHSDIKNVKDMRFLRGLNKSAVGVLYQPQLSWCGNEKLTRQTMKFIILSLDLDDEKSTVINMLQGLPNTLHTIIPLSNGCVLAGVNELLYVDNTGALQGAISLNAFSNSGLNTRIQDNSKLQAFFEQPLCYFATQSNGRDILLLMDEKARMYNVIIEAEGRLLTTFNCVQLPIVNEIFKRNMMPTSICGNMNLETGSLFIGFQSGDAMHVRLNNLKSSLEHKGTVSETLETDEDYMELYGNNAEKEKKNLETESPFDIECLDRLLNIGPVTSLAVGKASSIEHTVAKLANPNKDELSIVATSGNGTGSHLTILENTIVPTVQQALKFISVTQIWNLKIKGKDKYLVTTDSSQTRSDIYSIDRDFKPFKAADFRKNDTTVSTAVTGGGKRIVQVTSKGVHLFDINFKRMMTMNFDFEVVHVCIKDPFLLLTNSKGDIKIYELEPKHKKKFVKTVLPDALKEIIITFGVILESNMCNKYINGLEKSEEPQLLFTFVTADNQIVFFTKDHNDRIFQLNGIDDFRQKLFISTYQLPEDINPDPSIKQVIISRLGHKHKQEYLTILTFGGEVYLYRKCIDNPDRFIKCDHELLITGAPENAYPKGVQGVERVAHYIEDYNGYSVIFITGTVPYIIIKEDNSVPRIFPFANITLVSMTRWGENSVMCVDDVKNARIMTLNLDRDRYYGNKMSLAKIYLEDPLEDFQTLNNITYHERTQTFIVSYAKSIDYVALSEEDEPLVGYNPDKIHAMGFQSGIILLSPKSWEIIDKIEYGKNSLINDMRTMMIQLNSNTKRRREYLVVGNTYVRDEDIGGTGSFYLYDITEVVPEPGKPDTNYKFKDIFQEDIRGTVSTVCEISGRFMISQSSKAMVRDIQEDNSVVPVAFLDMPVFITDAKSFGNLMIIGDSMQGFSFLGFDAEPYRMLTLGKSVSKLETMCVEFLVNNGDVYFLVTDRNNLMHVLKYAPDEPNSLSGQRLVHCTSFNLHSTNTCMRLIKKNDEFGKVSRGFGIYMPSFQCIGSQADGTIFKVVPLSEASYRSLYLIQQQLIDKEVQLCGLNPRMERLENPFYQMGHILRPMLDFTVLKRFATLSIPTRMTMASKAGRQAHAEIWRDLIDIEYSLTSLNKIT
What is the function of this protein?
RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.  Involved in poly(A) site recognition.  May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).
What are the official names of this protein?
Protein CFT1, Cleavage factor two protein 1.
What is the protein family that this protein belongs to?
Belongs to the CFT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GRPE_ONYPE
Sequence: MFLEKDQDNLDNLETQAKELHKDCKECKNCQKEETKTTNKDNQKEDETVKNQSNQSNQSNQTKQTNTKQQKHQPKENSHLQITKLQTQIKELQQQLTQQKKSFDEELLKNQAELINFKKRAQTQKANELKYASSNFITNLLMPLEQLEKVIDMPTQNELLQKYLLGFKLLQQQIKKVLQDEGVEEIEALNKPFDPALHHALETVCDPKKPDKTNLAVLQKGYLYKKRILRPTLVKVNEWSDKNDKNE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_CROS8
Sequence: MNIRPLHDRVIVKRKEIESKSAGGIVLTGSAAGKSTRGEVLAVGNGRILENGEVKPLDVKVGDIVIFNDGYGVKTEKLDDQEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK2_PONAB
Sequence: MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase isoform type-2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
Protein: ENGB_BACAA
Sequence: MKVTKADIVISAVKPEQYPDGDLPEIALAGRSNVGKSSFINKILNRKKLVRISSKPGKTQTLNFFLINEMMHFVDVPGYGYAKVSKTERAAWGKMIETYFTTREQLDAAVLVVDLRHKPTNDDVMMYDFLKHYDIPTIIIATKADKIPKGKWQKHLKVVKETLDIESGDEVVLFSSETGLGKEEAWKAIHKFTKTKNA
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: TLL1_DANRE
Sequence: MDYLYSALTSKMNWIALLLAGLTFCCKVSVHSCLDYDDSYDYYEEEKTETIDYKDPCKAAVFWGDIALDDEDLKMFHIDGTIDLKQQTHGRQGHTSGGLGEHVPTKKRGSLYLLLDRIRRLGFESWPVNSSKDVSSIKTGIRRVNSARNVKSRVPRAATSRAEKIWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQTCVTFIEKTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDENGVRPAIGQRTRLSKGDISQAKKLYRCPACGETLQDSVGNFSSPGYPNGYPSYTHCVWRISVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKAPLLGRFCGDKIPEVLVSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEISKDSGQIQSPNYPDDYRPSKECVWRITVSEGYSVGLSFQVFEIERHDSCAYDYLEVRDGLSENSPLIGRFCGYDKPEDIRSTSNNLWMKFVSDGTVNKAGFAANFFKEEDECLKPDNGGCEQRCVNTLGSFKCACDPGYELAPDKKSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISMQFEAFELEGNEVCKYDYVEVRSGLSSDSKLHGKYCGTEVPEVITSQYNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECINTIGSYVCQCRNGFILHENKHDCKEAECEHKIHSTTGTISSPNWPDKYPSRKECTWDITATPGHRVKISFNEFEIEQHQECAYDHLEAFDGDSDKTPILSRLCGNKIPEPLISTGNKMYLRFISDASVQRKGFQATHSTECGGRLKAEARQKNLYSHAQFGDNNYPGHTDCEWLIVAESGYGIELTFTTFEVEEEADCGYDYIELYDGYDTGAHKIGRFCGSGPREELYSAGDAVLIHFHSDDTISKKGFHIRYTSTKFQEALHTRK
What is the function of this protein?
Required for patterning ventral tissues of the tail.  May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes.
What are the official names of this protein?
Dorsal-ventral patterning tolloid-like protein 1, Mini fin protein.
Protein: TM129_MOUSE
Sequence: MDSPEVTFTLAYLVFAVCFVFTPNEFYSAGLTVQNLLSGWLGSEDAAFVPYHLRRTSATLLCHSLLPLGYYMGMCFAASEKQLYSPGQAPEAWQLFLLLAVTLPLLSCTLIYYWSWDRWTRHPLAQTLALYALPQSGWQAVASSINTEFRRIDKFATGAPGARVIVTDTWVMKVTTYRVHVAQQQDVHLTVTESRQHDLSPDSNLPVQLLTIRVASTSPGTQPFDIRLNSSEYGELCEKLHAPIRSAANVVIRQSLGDLFLETFASHVEVNPAYSVPSNQELEPCIGCMQTRASVKLVKTCQEPAVGECQQCYCRPMWCLTCMGKWFASRQDPQRPDTWLASRVPCPTCRARFCILDVCCVR
What is the function of this protein?
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2.  Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase TM129, RING-type E3 ubiquitin transferase TM129.
What is the protein family that this protein belongs to?
Belongs to the TMEM129 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TOLB_RALSO
Sequence: MMRNVWKSGLRRSAWIGLLMVLCVGVARAQLYVEIAGAGSSQYPIAIANFQGESQIPQDITAIVRADLVHSGRFSNVDVAGAVVPDSPAPDLGAWKSRGAAAFVGGTVTRNGDRYEIRFRLYDTAKGESLGGLALTRGEGQLRLAAHEIADYIYQKLIGDRGVFATRLSYVSKVGRRYQLQISDSDGANPQVALTSNEPIISPAWSPDGTKVAYVSFESRKPVVYVHDLISGRRAVISNQKGNNSAPAWSPDGRRVAVALSRDGNTQIYQVNADGSGLRRLTRSSAIDTEPSFSPDGRSIYFTSDRGGAPQIYRMPTEGEDAGSAQRVTFKGGYNTSPRVSPDGKLLAYISRVGGAFKLYVQDLSNGDVTGLTDTSYDESPSFAANGKFILYATRVGGRSVLAAVSTDGRTRQILSLQAGTVREPAWGPFMQ
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS12_STRZJ
Sequence: MPTINQLVRKPRKSKVEKSKSPALNVGYNSHKKVQTNVSSPQKRGVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKDLPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: AAKG1_HUMAN
Sequence: METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP
What is the function of this protein?
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.  In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.  AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.  Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.  Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.  ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.  ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
What are the official names of this protein?
5'-AMP-activated protein kinase subunit gamma-1, AMPK gamma1, AMPK subunit gamma-1, AMPKg.
What is the protein family that this protein belongs to?
Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
Protein: GSA_THEVO
Sequence: MSSKELFELAAKLFPMGVNSPVRYFKDYPFYVKEGKGSTILDVDGNKYIDYCLGYGPLILGHSDPDVTRAVIEQAEKGLLFGEPSENEIKLAEMIKETSKNIEMMRFTNSGTEATMHAIRLARAITGRKLIVKMEGGFHGAHDYSLIKSGSGTLTFGSPSSPGIPDEVAQTVIVGKYNDENNIKEIFQKYGDKIAAVITEPIMGNAGVILPKQGFLEFLRDITQKHGSLLIFDEVITGYRFAFSPFQDIMRIDPDITTMGKIIGGGLPIGLFGGSEEIMKNISPSGNVYEAGTFSGNPMSMAAGYAAMEKLSKQDYSILKKRTQKLVSGIDDILDRKHITHTIKYYGTMFQVFFADHVNNYDDALKARKEVYFKLFKALSKNGVYLPPSQYETNFVSFAHSDSDIDATLAAFEKAVAEMD
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCA_ECO45
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQGHSVGYDARTNAALDTANTISSVKRLMGRSLADIQQRYPHLPYQFQASENGLPMIETAAGLLNPVRVSADILKALAARATEALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIPDRSDNRVQRELLDAAIAAKIALSDADSVTVNVAGWQGEISREQFNELIAPLVKRTLLACRRALKDAGVEADEVLEVVMVGGSTRVPLVRERVGEFFGRPPLTSIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPALPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDSEIASMIKDSMSYAEQDVKARMLAEQKVEAARVLESLHGALAADAALLSAAERQVIDDAAAHLSEVAQGDDVDAIEQAIKNVDKQTQDFAARRMDQSVRRALKGHSVDEV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CYH4_MOUSE
Sequence: MDVCHTDPAELSSGEAKELQQIKWHRKQLLEDIQKLKDEIADVFAQIDCFESTEESRMAQKEKEMCIGRKKFNMDPNKGIQYLIEHKLLTSDVQDIAQFLYKGDGLNKTAIGTYLGEKDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAARYCLCNPGVFRSTDTCYVLSFSVIMLNTGLHNPNVRDRPPFERFVTMNRGINSGSDLPEEQLRNLFDSIKSEPFSIPEDDGGDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVEDPKKPFCLELYNPSCRGQKIKACKTDGDGKVVEGKHESYRISAANAEERDQWIEAIRASITRVPFYDLLSARKKKIVGK
What is the function of this protein?
Promotes guanine-nucleotide exchange on ARF1 and ARF5.  Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity).
What are the official names of this protein?
Cytohesin-4, PH, SEC7 and coiled-coil domain-containing protein 4.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ATPB_COLP3
Sequence: MSTGKVVQIIGAVVDVEFPQDAVPQVYDALKITEGDLEGLVLEVQQQLGGGVVRTIAMGTSDGLRRGLNVVNTGQGIQVPVGVETLGRIMNVLGEPIDEAGPIGEKDRWSIHREAPAYAEQSMSNELLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMNDSNVLDKVSLVYGQMNEPPGNRLRVAFTGLTMAEKFRDEGRDVLFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTNKGSITSIQAVYVPADDLTDPSPATTFAHLDATVVLSRDIASQGIYPAIDPLDSSSRQLDPLVVGTEHYETARGVQTVLQRYKELKDIIAILGMDELSEEDKQTVSRARKIQRYLSQPFFVAEVFTGSPGKYVSLKDTIAGFKGILAGEYDDMPEQAFYMVGGIEEAIEKANKM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.