PharMolix/UniProtQA huggingface dataset:
Protein: RBFA_DESPS
Sequence: MSVWDPKEILDSIGLGKRTEVKRSTRVADAIRKELAVLLLEKIRDPKLQDVGISRVTATDDLTIVKIYYTIYGPHKHVKAVDKAFLAATGFIRSHLARTLNMRYTPNLQFCYDKTAEKVAEIENIFQEIAKERQDNGENS
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYT2_ARATH
Sequence: MATMLKVSLVLSLLGFLVIAVVTPSAANPFRKSVVLGGKSGVPNIRTNREIQQLGRYCVEQFNQQAQNEQGNIGSIAKTDTAISNPLQFSRVVSAQKQVVAGLKYYLRIEVTQPNGSTRMFDSVVVIQPWLHSKQLLGFTPVVSPVY
What is the function of this protein?
Specific inhibitor of cysteine proteinases.  Probably involved in the regulation of endogenous processes and in defense against pests and pathogens (By similarity).
What are the official names of this protein?
Cysteine proteinase inhibitor 2, AtCYS-2.
What is the protein family that this protein belongs to?
Belongs to the cystatin family. Phytocystatin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLYA_CHLT2
Sequence: MASLLDRYLRNISDKSQQNLASVAYLASLDHLLHAFPSIGQSIVQELKSQRSRLKMIASENFSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWECAETAKELFGAESAFVQPHSGADANLLAIMSIITQKIQSPAVQQLGYKTINDLPEQEYEALKAEMAQHKCLGPSLNSGGHLTHGTVRMNIMSKLMHCLPYEVNLDTELFDYDEIAKIAKEHKPTVLIAGYSSYSRRFNFATLKQIAEDCGAVLWVDMAHFAGLVAGGVFVGEENPMPYADIVTTTTHKTLRGPRGGLVLAKKEYANTLNKACPLMMGGPLPHVIAAKAIALKEAMTINFRKYAHKVVENAQTLAEVFQRNGLRLLTGGTDNHMLIIDLTSLGVPGRIAEDMLTSVGIAVNRNTIPSDASGQWKTSGIRLGTPALTTLGMGSAEMEEVANIIVKVLRNITVRSNAESGSSKSEGELSEGIAQEARQRVADLLGRFPLYPEIDLETLV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_XANCB
Sequence: MIQMQSYLDVADNSGAKEVMCIKVLGGSKRRYAHIGDIIKVTVKDAIPRGKVKKGEVYDAVVVRTRKGVRRPDGSLIRFDGNAAVLLNNKQEPIGTRIFGPVTRELRSEKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: WECG_ENT38
Sequence: MTDNTSAPMYTLRGLQLIGWRDMQHALDFLCAADGQIKSGTLVAINAEKMLAIEDNAEVKGLIEAAEFKYADGISVVRSIRKKYPQARVSRVAGADLWEALMARAGAANTPVFLIGGKPEVLSQTEQKLRAQWNVNIVGSQDGYFKPEDRQALFERVRDSGAKIVTVAMGSPRQEILMRDCRMICPDALYMGVGGTYDVFTGHVKRAPKVWQNLGLEWLYRLLSQPSRITRQIKLLRYLAWHYTGKM
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: TRA5_LACLA
Sequence: MTQFTTELLNFLAQKQDIDEFFRTSLETAMNDLLQAELSAFLGYEPYDKVGYNSGNSRNGSYSRQFETKYGTVQLSIPRDRNGNFSPALLPAYGRRDDHLEEMVIKLYQTGVTTREISDIIERMYGHHYSPATISNISKATQENVATFHERSLEANYSVLFLDGTYLPLRRGTVSKECIHIALGITPEGQKAVLGYEIAPNENNASWSTLLDKLQNQGIQQVSLVVTDGFKGLEQIISQAYPLAKQQRCLIHISRNLASKVKRADRAVILEQFKTIYRAENLEMAVQALENFIAEWKPKYRKVMESLENTDNLLTFYQFPYQIWHSIYSTNLIESLNKEIKRQTKKKVLFPNEEALERYLVTLFEDYNFKQSQRIHKGFGQCADTLESLFD
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Transposase for insertion sequence element IS905.
What is the protein family that this protein belongs to?
Belongs to the transposase mutator family.
Protein: RPO6_SACSH
Sequence: MGLERDGILSQDLHFNEVFVSLWQNKLTRYEIARVISARALQLAMGAPALIDINNISSTDVISIAEEEFKRGVLPITIRRRLPNGKIILLSLRKS
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_AGRVS
Sequence: MAEVSSSTVRRPFHRRRKTCPFSGANAPKIDYKDVRLLQRYISERGKIVPSRITAVSQKKQRELAKAIKRARFLGLLPYVVA
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: NUOD_MYCVP
Sequence: MTTSQQPPERVVVVGGQDWDQVVAAARQNAAEHAGERIVVNMGPQHPSTHGVLRLILEIEGEIIVEARCGIGYLHTGIEKNLEFRNWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDAIPERASVIRVMMMELNRISSHLVALATGGMELGAMTAMFLGFRERELILSVFETITGLRMNNAYIRPGGVAADLPDEALPQVRDLLTLLPKRLRDMEDLLNENYIWKARTQGIGYLDLTGCMALGITGPVLRSTGLPHDLRKAQPYCGYETYDFDVVTDDQCDSYGRYLIRVKEMHQSIRIVEQCVQRLERSVGAPVMITDKKLAWPADLKVGPDGLGNSPEHIAKIMGHSMEGLIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQAVAAMCEGGMVADAITAVASIDPVMGGVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GLPK_RENSM
Sequence: MSQYVIAIDQGTTSSRAIIFDHDGNIVSTGQLEHEQIFPKAGWVEHNATEIWNNTREVIGTALSKANLTRHDIAAVGITNQRETAVVWDKTTGEPVYNAIVWQDTRTQSIVDELAVGGGVERFKDKVGLPLATYFSGTKIKWILDNVDGARERAAAGDLLFGNTDSWVTWNLTGGVDGGVHITDVTNASRTMFMDLATLSWDQEILDAFGVPASMLPTIKSSSEVYGTVHTSQLLREVPVAGILGDQQAATFGQAAFNTGEAKNTYGTGCFLIFNTGEEIVHSKNGLLTTVGYKLGDAPTHYALEGSIAVAGSLIQWLRDTLGMISSAPEVEELAASVEDNGGVYIVPAFSGLFAPYWRSDARGAIVGMTRYVNRNHIARAALEATAFQTREVLDAVNADSGVPLTELKVDGGMVANDALMQFQADILGVPVIRPKVTETTALGAAYAAGLAVGFWNDLGELSSNWAEDKRWEPAMEEDERARQLRLWKKAVTKSMDWVDEDVR
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: MOBA_STAEQ
Sequence: MKAIILAGGESSRFGKAKAFAKIDNQYFYQKIIETLKSTNMFNRIIISTNSQLASQFEYEYVIIDDEHHQNKGPLTGIYSVMKQYMDEELFFIVSVDTPMITSKAVNGLYHFMVSNLIESRLDIVAFKEGEICIPTIGFYTLSTFPFIEKALNSNHLSLKHVFKQLSTDWLDVTEIDSPYYWYKNINFQHDLDSLKMQINE
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Probable molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NB1_MYCBP
Sequence: MSSGAGSDATGAGGVHAAGSGDRAVAAAVERAKATAARNIPAFDDLPVPADTANLREGADLNNALLALLPLVGVWRGEGEGRGPDGDYRFGQQIVVSHDGGDYLNWESRSWRLTATGDYQEPGLREAGFWRFVADPYDPSESQAIELLLAHSAGYVELFYGRPRTQSSWELVTDALARSRSGVLVGGAKRLYGIVEGGDLAYVEERVDADGGLVPHLSARLSRFVG
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase 1, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: RPO10_METMA
Sequence: MIPVRCFSCGKVISNYWDEYKRRVTDGEDAAAVLDDLGITRYCCRRMFLSHVELIDVLSPYQ
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit N.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_BACCQ
Sequence: MKIDILTLFPDMFTGVFGSSILKKAQEKEAVELRVVNFRDYTTSKHNSVDDYPYGGGAGMVLTPQPIFDAVEDLTKETERKPRVVLMCPQGERFTQKKAEELAEEEHLIFVCGHYEGYDERIREHLVTDEISIGDYVLTGGELASMVITDSVVRLLPGVLGNHASQVEDSFSTGLLEHPHYTRPADFRGMKVPDVLMSGNHKNIDEWRHKESLRRTYTRRPDLLEERELSKQEKKWLEQIKEGK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STHA_SALPC
Sequence: MPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNAHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPSDVDFSHPRIYDSDSILSLHHEPRHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVNSMYQTALPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFW1_DROME
Sequence: MLAYTHGTWLLLLLLLVAGACARPEIAHTPDPAALGEESTPHAHAHPQARHHHHAHPHAPLKEDEQGTAIPAPILTTDNVGIGETTTASSLAETQSMSDPGSVTDTTSTSTSHSTSTTSTTSPAPLPPAAPEQPEYLKHCFYAEEQLCGHTFDGRAETSEGQGSTVAQSEAQNRGGQGNSQCQCREHPTRPNSWYCCNISQLTMISSCSNISKWTNLHVRNMTVEDMDLSNPIFRSLQSLAVTDGNITRLVNAFPRLSALKCLNISNNNISEIHSRAVKDVPHLEFFGMSNNNLSLVPHRNQNKNITLDISGNMRMLCTPLNEIIYTESINFLNPKHSYCQYNATHTWFQSTDKVSVEQLENRKRCVTNCPVIPNYGSCNCTLENIMIIQDNQSKPQCHVDCSNLGLVELPQRLPDNTFMLNITNNKITSLGDYFHTNPTYHNINRLLADNNQISSIYEFEGTKFIETFQRIYMRNNSLSKIPEYFLNNALMDSGLGRRIYLAGNKLQCDCNSAKTLQNWLKERSSDIPDYMEIRCRNMPQRVIELQEAKLCQSPPDWTDYIYYLIAAEVLLLLALITKVSYDYWVFKTAGYLPWPASKMPKLPCDWLCES
What is the function of this protein?
Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes.
What are the official names of this protein?
Protein halfway, Protein singed wings.
Protein: FOLD_AQUAE
Sequence: MALILDGKSLSKKIREEIKKEVENFTSKGFRPPALAVILVGNDPASEIYVNNKRKACEKVGIKSLFYHLPQDVSEEKLLGLIYELNMNEEVDGILVQLPLPKHIDQTRVILSISPEKDVDGFHPENMGKLVAQIEDGFIPCTPLGIDILLKHYGIDVKGKDVTIVGAGFIVGRPLSLLMLWRNATVSVCHIHTKDVKKFTKEADILISATGVPHLIKEDMIKEGAVVVDVGISRLNGKIVGDVDFERVKEKASAITPVPGGVGPMTVTALLLNTLKSYKRKFAHLISTTNP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TSAD_RHIME
Sequence: MRILGIETSCDETAASVVLRDEEGRGRILGDVVLSQLEEHSAYGGVVPEIAARAHVEALDALIEEALLRAGVTLRDIDAVAATSGPGLIGGLIVGLMTGKAIARATGKPLYAVNHLEGHALTARLTDGLSFPYLMLLVSGGHTQLILVKGVGEYERWGTTIDDALGEAFDKTAKLLGLPYPGGPAVERAAQAGNAERFDFPRPLVGDARLDFSFSGLKTAVRQAAQSLGPVTDQDIADVCASFQRAISRTLRDRVGRGLKRFRADFASVDQPALVVAGGVAANQTLRRTLQSLCDEHGFRFIAPPLQLCTDNAAMIAWAGAERLAAGLPADGLDAAPRSRWPLDSEAKALIGSGRRGAKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCSA_NOSS1
Sequence: MNLVSLQNWLDNASFAVLFLTMLLYWIGAAFPGLPAINALGTAGMAIANLSIATLLGARWIEAGYFPLSNLYESLFFLSWGITTVHLIAENSSRSRLVGVFTTPVAMGIVAFATLTLPSDMQVSEPLVPALKSNWLMMHVSVMMLSYSALMVGSLLAIAFLVITRGNNIQLQGSSVGNGGYRTNGYRLMKAGELVSQPATPPVENNGFTRLESQNNGNSNTAVLNLATTPQTPTLTSTETLSPQRLSLAETLDNISYRIIGLGFPLLTIGIIAGAVWANEAWGSYWSWDPKETWALITWLVFAAYLHARITRGWQGRRPAILAASGFVVVWICYLGVNLLGKGLHSYGWFF
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: TUSA_ACTP2
Sequence: MTDIKIDQTLDTLGLRCPEPVMLTRKTIRNMAEGEVLLIVADDPATTRDISSFCEFMDHQLLNSETENTPYRYWVKKGL
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DECO_BPSPP
Sequence: MSKRIPRFLRNIQLPAGPQGPKGDPGPKGDTGAKGADGFGTEAQYNDIISRLEALEQSSGGGTT
What is the function of this protein?
Decoration protein that binds to each capsid protein hexamer after capsid expansion and forms spikes at the surface of the capsid.  Each of the 60 hexamers has three copies of the decoration protein gp12 in its center.
What are the official names of this protein?
Decoration protein gp12, Gene product 12, gp12.
What are the subcellular locations of this protein?
Virion. Note=180 copies of the decoration protein are localized on the exterior of the capsid.
Protein: LIPB_NITOC
Sequence: MDKRIPVGADTLRIRNLGLQDYDTVWQAMRDFTVRRDSATVDELWWVEHPPVFTLGLNGQECHLRDVGDIPVVRCDRGGQVTYHGPGQSIVYILVDLRRRALGVRQLVDALELSVVDLLQSYEIETERRANAPGVYVQGRKIASLGLRVRKGCCYHGLSLNVAMDLSPFYRIDPCGYSGMEVIDLKRLGMELPLADVQQNLSRYLVRRLGYSAPFYGEENRMIK
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_KORVE
Sequence: MAKVYHDSSADLSIIRGKKVGIVGYGSQGHAHALNLVDSGVQVRVGLRPSSSSKAKAEKSGLQVGSVSDVAQWADVIMILAPDTEQAAIYEKDIAPHLKPGKTLMFAHGFNIRYGTITPPEGIDVSMVAPKAPGHRVREVFTEGGGTPALFAIHQDASGKAREIALSYAAAIGTTRAGVLETTFKEETETDLFGEQAVLCGGAAALVKAGFETLVEAGYQPELAYFECLHELKLIVDLMYRGGLNYMRYSVSDTAEYGDYIAGPRIITDETRKNMKQLLTDIQDGTFAKNWINENKTGRPWFEKKRTDEQEQQLEDVGAQLRDMMTFLNPVKIKQKSEQKEAVAQ
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: ROA2_BOVIN
Sequence: MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY
What is the function of this protein?
Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles.  The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting.  Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs.  Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus.  Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity).  Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity).  Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs.  Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts.  Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs.  Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity).  Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoproteins A2/B1, hnRNP A2/B1.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasmic granule. Secreted, extracellular exosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Not found in the nucleolus. Found in exosomes follwong sumoylation.
Protein: US03_VZVD
Sequence: MNDVDATDTFVGQGKFRGAISTSPSHIMQTCGFIQQMFPVEMSPGIESEDDPNYDVNMDIQSFNIFDGVHETEAEASVALCAEARVGINKAGFVILKTFTPGAEGFAFACMDSKTCEHVVIKAGQRQGTATEATVLRALTHPSVVQLKGTFTYNKMTCLILPRYRTDLYCYLAAKRNLPICDILAIQRSVLRALQYLHNNSIIHRDIKSENIFINHPGDVCVGDFGAACFPVDINANRYYGWAGTIATNSPELLARDPYGPAVDIWSAGIVLFEMATGQNSLFERDGLDGNCDSERQIKLIIRRSGTHPNEFPINPTSNLRRQYIGLAKRSSRKPGSRPLWTNLYELPIDLEYLICKMLSFDARHRPSAEVLLNHSVFQTLPDPYPNPMEVGD
What is the function of this protein?
Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis.  Phosphorylates proteins 24 and 27, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress.  Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3.  Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface.  Promotes virus intracellular spread by restructuring host cell cytoskeleton.  Blocks host apoptosis to extend cell survival and allow efficient viral replication.  Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing (By similarity).  Down-regulates class I major histocompatibility complex (MHC-I) surface expression.  Additionally, phosphorylates IE62 and targets it to the cytoplasm.  The nuclear exclusion of IE62 enables the packaging of abundant levels of IE62 into virions.
What are the official names of this protein?
Serine/threonine-protein kinase US3 homolog, Protein kinase ORF66.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.