PharMolix/UniProtQA huggingface dataset:
Protein: TRPE_ARCFU
Sequence: MQKHEYVNPVKLYSAIRDEKFPFILESAEKSGRARYTYISFNPLYTVRVGSRTRVDGEVISKISDPFDALNEIHVKGLLVGYVAYEAVKNYIGKKPQTPSVFGCYDGYFVYDHYLRKLFSVNVENADKIVERAKRVEVEQVRGNSEVLRAGSREKFEKMVERGKEQIFEGEVYQIVLSREYVVDTDLSPFQMYLNLRETNPSPYMFLLEFDRALIGSSPETMGRVEGNSFIINPIAGTARREAGREKEIAEKLLSDEKERAEHVMLVDLARNDVRKVCRAGSVRVSRFMEVVEYPSVLHIESEVVGELKAGVTHFDAMKATFPAGTVTGAPKLRAIELIDEIEGDCRGVYAGAVGYFSENVSDLAIAIRMIEFDGKARIRAGAGIVADSVPEREFFETENKIARVLRAVGL
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 1, AS, ASI.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.
Protein: ICAB_STAAM
Sequence: MKYRKLIILVLSILIILPVSTLDGHHIANADDDSPKKLKYKENSALALNYHRVRKANFLNNFIYFFSSSKEIKNYSVSQSQFESQIKWLKSHDAKFLTLKEFLYYKKKGKFPKRSVWINFDDMDETIYENAYPILKKYKIPATGFIITGHVGEENFHNLDMISKKELKEMYKTGLWEFETHTHDLHNLSKNNKSKLMKASEATIIKDLNKSEKYLTKNFKKSQKTIAYPYGLMNDDKLPVIKKAGLKYGFSLEEKAVTPNSNDYYIPRILISDDAFEHLIKRWDGFHEKD
What is the function of this protein?
Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide.  N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions (By similarity).
What are the official names of this protein?
Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase, PNAG N-deacetylase, Poly-beta-1,6-GlcNAc N-deacetylase, Biofilm polysaccharide intercellular adhesin deacetylase, Biofilm PIA deacetylase, Intercellular adhesion protein B.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Attached to the cell surface.
Protein: CLPP1_MYCPA
Sequence: MNPQIQPQARYILPSFIEHSSFGIKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLQGVIQGQFSDLEIQAAEIERMRTLMETTLARHTGKDAATIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DACT3_MOUSE
Sequence: MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDEEDAEEDEDAAAARRAAAALEEQLEALPGLIWDLGQQLGDLSLESGGLDQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSGSYGRLGPSDPRGIYASERPKSLGDASPSAPESVGARVAVPRSFSAPYPTAAAGAETCSSAERRARAGPFLTPSPLHAVALRSPRPSGRVPCGSPDGAASRPLDGYISALLRRRRRRGAGQPRTSPGGADGGARRQNGARPRPPEASPPPGGARPAREPSTERAWAAAWEAEVPPEPAPPAAASPPSSPAEGRLVKAQYIPGAPAASRGLPGRAARRRAPPLTRGRSVEQSPPRERPRAAGRRGRLAEPSGRRGSPRARKAARSQSETSLLGRAHAAPPPKYPTAERDEPRPPRPRRGPAPTPTVQACRRWRSTAEIDAPDGRRPRARVPAPRGPAPSPSAPPRRLLYGCAGSDSECSAVGRPVPLGRRMPSGCAPGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAAAGASPSGPGGAAGGGTPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV
What is the function of this protein?
May be involved in regulation of intracellular signaling pathways during development.  Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins (By similarity).
What are the official names of this protein?
Dapper homolog 3, Dapper antagonist of catenin 3.
What is the protein family that this protein belongs to?
Belongs to the dapper family.
Protein: AGUB_SOLLC
Sequence: MAEKNRLVTVAALQFACTDDVSTNVATAERLVRAAHQKGANIILIQELFEGYYFCQAQKEEFFHRAKPYPGHPTIVRMQNLAKELGVVIPVSFFEEANNAHYNSVAIIDADGTDLGLYRKSHIPDGPGYQEKYYFNPGDTGFKVFQTKYAKIGVAICWDQWFPEAARAMALQGAEVLFYPTAIGSEPQDDGLDSRDHWRRVMQGHAGANVVPLVASNRIGKEIIETEHGNSEITFYGYSFIAGPTGELVAAAGDKEEAVLVAQFDLDKIKSKRHGWGVYRDRRPDLYKVLLTLDGSNPVK
What is the function of this protein?
Involved in polyamine biosynthesis.
What are the official names of this protein?
N-carbamoylputrescine amidase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily.
Protein: LOLD_SHEON
Sequence: MQDVLLQVQAVSKSYHDGDVTTQVLSDVDLQVFKGEQLAIVGTSGSGKSTLLHIMGTLDKPSSGKVLLAGEDLYQVSSARQAQIRNQDLGFIYQFHHLLPEFTALENVAMPAFIQGRDRTLAQADAKVLLERVGLGHRMSHIPAELSGGERQRVAIARALINKPKLVLADEPTGNLDAKSGEAVYELIRELANQLGTAFVVVTHDPKLAARMDRQLTMKNGYLQVPESAQ
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COAA_SALNS
Sequence: MSIKEQSLMTPYLQFDRSQWAALRDSVPMTLTEDEIAQLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSHLIYDVIPEGDKTVAQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEELLQTWYINRFLKFREGAFTDPDSYFHNYAKLSKEEAVNTAASLWKEINWLNLKQNILPTRERASLIMTKSANHAVEQVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMGO2_MOUSE
Sequence: MSLRFHTLPTLPRAVKPGCRELLCLLVIAVMVSPSASGMCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDADWIPVSFVKLSTLILRHNNITSISTGSFSTTPNLKCLDLSSNRLKSVKSATFQELKALEVLLLYNNHISYLDPAAFGGLSHLQKLYLSGNFLTQFPMDLYTGRFKLADLTFLDVSYNRIPSIPMHHINLVPGRQLRGIYLHGNPFVCDCSLYSLLIFWYRRHFSSVMDFKNDYTCRLWSDSRHSHQLQLLQESFLNCSYSVINGSFHALGFIHEAQVGERAIVHCDSKTGNGNTDFIWVGPDNRLLEPDKDMGNFRVFYNGSLVIENPGFEDAGVYSCIAMNRQRLLNETVDIMINVSNFTINRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKAKRQKNTLSQSSAHSSILSPGPTGDASADDRKAGKRVVFLEPLKDTAAGQNGKVKLFPSETVIAEGILKSTRAKSDSDSVNSVFSDTPFVAST
What is the function of this protein?
Required for depolarization-dependent survival of cultured cerebellar granule neurons.  May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3.  May contribute to signal transduction through its intracellular domain (By similarity).
What are the official names of this protein?
Amphoterin-induced protein 2, AMIGO-2, Alivin-1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. AMIGO family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity).
Protein: RISB_STRM5
Sequence: MSHYEGDLRTPESARFAILASRWNARITDTLVAGARQSLAGNGIAEANIDVIRVPGAWELPLVAARLAAAHEHAAILTLGCVIRGDTRHYEHVADRCAEGLMRVQLDFGVPVLNGVLAVERAEDAEARAGGSHGNKGEEVALAALEMVNLLEQLP
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: PMIP_MAGO7
Sequence: MLKLLRPRPWVCNSCLNRVAFPKPYPVGSRSTRWLSTAQSAAPAVSIPPVNPVPADHTTSGTHDDALLGKIFDCSSAWRDFSARSAKFPTENAGLFRNAYLTSPDGFLTFAQSSLSKASAIVNRVLGASTIEEYKTIVRDLDRLSDLLCRVIDLSDFVRVTHPDVRIQRAASEAWYMVYQYMNQLNTMTGLNDQLGKAMENSDVTKTWSEEEMAVAQLLKLDFMKSAVNLPQAARDRFVDLSQRISEIGSDFVNEMAPEQRRVVLPSSKFQGMDPQIARRFTKHGYMQLPTMSGEAAAALRTVHDEETRKAVYLAIRTASSRSVGLLEALLKHRAELADLAGFESYGHMTLRDRMMAKTPESINKFLVELSKNNAPRVLQEVDSLLQEKKTLLASPSATLNPWDREYYIQRIRNAQGKNVKHDNFFASYFSVGRVMQGLSRLFTRLYGIRFVPRETLPGEKWHPDVRRLDVVSDTDGHVAVLYCDLFYREDKSPNPAHFTIRCSRAISEDEISEAAVSTSEGGPAFGSPESAANDGMAASRGASGGPLKQLPTIALVCDFPQRDNPLSGSKSKPASLTFASLETLFHEMGHAIHSVLARTSFQNVAGTRCATDLAELPSTLMEYFASDPSVLSLFARHAETDEPLDYDLLAERVRSRGRFEGCDTDYQIILAMLDQAYHSPLASSESFDTTRAYHDLQREHSPLGPDPSSTRWQGFFGHLFGYGSTYYSYLFDQVLAERAWKKVFSSGQDGAALSREAGEHLKESLLKWGGSREPWRCVSDVLRDERIAGGGEEAMALVGSWGTSNKSTMKH
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP, Octapeptidyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GUAA_STRPM
Sequence: MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFELGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSNDCPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSVVGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPGPGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFAQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PRS4_ORYSJ
Sequence: MGQGTPGGMGKQGGAPGDRKPGGDGDKKDRKFEPPAAPSRVGRKQRKQKGPEAAARLPNVAPLSKCRLRLLKLERVKDYLLMEEEFVAAQERLRPTEDKTEEDRSKVDDLRGTPMSVGSLEEIIDESHAIVSSSVGPEYYVGILSFVDKDQLEPGCSILMHNKVLSVVGILQDEVDPMVSVMKVEKAPLESYADIGGLDAQIQEIKEAVELPLTHPELYEDIGIRPPKGVILYGEPGTGKTLLAKAVANSTSATFLRVVGSELIQKYLGDGPKLVRELFRVADELSPSIVFIDEIDAVGTKRYDAHSGGEREIQRTMLELLNQLDGFDSRGDVKVILATNRIESLDPALLRPGRIDRKIEFPLPDIKTRRRIFQIHTSKMTLADDVNLEEFVMTKDEFSGADIKAICTEAGLLALRERRMKVTHADFKKAKEKVMFKKKEGVPEGLYM
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
What are the official names of this protein?
26S proteasome regulatory subunit 4 homolog, Tat-binding protein homolog 2.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS19_MYCS5
Sequence: MARSLKKGPFADDHLLKKVQAIIDGKAPKKPIKTWSRRSTIFPDFVGLTFAVHNGKQFIEVYVTDDMVGHKLGEFSPTRTFSGHGADKSKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: RSMH_LACLS
Sequence: MPKTIAFKHDTVLLHETVDMLEVKPNGIYVDATLGGAGHSEYLLSKLTTGHLYSFDQDETAHANAKVRLSEQLAEDKVTLIKSNFRNLKSALAELDITKIDGILYDLGVSSPQFDDSQRGFSYKKEARLDMRMDQSQTLSAYEVVNDYPYEALVRIFFRYGEDKFSKQIARKIEQSRKIKPIETTIELADLIKSALPQKELKKKGHPAKRIFQAIRIEVNDELGAAEESIEQAIDLLKVDGRISVITFHSLEDRLTKSIFKEYSTVNVPKGLPMLPKEMEAKLKLINRKPVLASEEELEFNNRAHSAKLRVAQKQRD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_ERYLH
Sequence: MAETEIPTQLYLISPLDVRGGFPQRLERALEAGRGVVTAFQFRVKGIDQHEAARLAEPLQAICAAHDVAFVVNDSIALAKRLKADGVHLGQDDGSPKEAREQLGREAQIGVTCHASRHLAMEAGEAGADYVAFGAFFDSATKDKGDAEQPTLELLEWWSQVFEIPCVAIGGITPDNCQPLIEAGADFLAVSGAVWSGDERAAVQAFAEQIAAA
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: IF1_FRAT1
Sequence: MAKEDCIEMEGVVLEALPNTMFRVELENGRIVTAHISGKMRKNYIRILTGDKVVVEITPYDLTKGRIKFRSK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LT_POVSM
Sequence: MDYTLTREESKLLMELLGLPMEQYGNFPLMRKAFLQKCKIMHPDKGGDEQTAKMLISLYKKLESEVKSLNTDDGFSTEEIPTYGSAEWEQWWQTFNEDFDLFCHETFTVSDDEEEGGEKRKHSDEEEPSCSQATPPKKKKTSSAPKDMPELLRNFLSNAILSNKTLTCFLVYTTLEKSSLLYSKLSEKFKPTFISRHKLDNEGLIFLITPSKHRVSAITNFCSNLCSVSFLIVKAVIKEYSCYCALCVEPFVLVVENIPGGLNSDFFDAPQEASKNVSWKLIGEYALSIMCDDLFLLLGLYKEFAVNPSTCSKCDQKVIVDHYKYHSLHYANAMLFTDCKNQKAICQQAVDGVLAFRRVQTAQLTRKQLLAKRFEYHFNKLEQVFSAKSEVCIETYMAGVCWFECLLPEVNMKNFILQYLECVVQNVPKKRFWCFTGPVNTGKTTLAAALLDLCGGKSLNVNMPFDKLNFELGVAIDQFTVVFEDVKGQSENKNLPTGQGISNLDNLRDYLDGAVKVNLEKKHLNKKTQIFPPGIVTANEYIFPLTLKVRFCKIIKFIYQQHLFKSLKKTELLTKHRVLQSGLTLLLLLVFHCDVEDFLSELHPLVTKWRENINHEVSWSRYLEMKENVMNGLNILEKQQDSGIFTQTQDTECQQ
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription.
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.
Protein: HSLU_MARMS
Sequence: MSSMTPRETVNALDNHIIGQQKAKRAVAIALRNRWRRMQLPEEMRAEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKIEATKFTEVGYVGRDVESIIRDLVEMAIKMLREQETAKLRHKAEDAAEDRILDVLLPPARGGDPELEDNSTRQTFRKKLREGQLDDKEIDIDVADSPMGVEIMTPPGMEEMTSQLQNLFSSFGSQKTKKRKMKVKDAFRQVRDEEAAKLVNEEELKARAVEAVEQNGIVFLDEIDKVAKSSERSGGEVSREGVQRDLLPLVEGCTVSTKYGMIKTDHILFIASGAFHLSKPSDLIPELQGRLPIRVELDALTVDDFKRILVEPSMSLTKQYVALAKTEHINLNFTEEGIHRIAEIAFQVNERTENIGARRLHTVLERLLEEVSYSASDMPNDQTVDITAAYVDEQLGEIAENEDLSQYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCE1_SODAL
Sequence: MKSTVASALLVLAGTAVQAQSGPWQQCGGIGWQGPFTCVSGHTCQVLNDWYHQCVPGGGPSPPPTSPPPTTPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPTSPPPSSGSCPSTPGGLGSGNQRLPDPFTFHNGNTVTSAADFQCRQREVSSLIQQYELGQFPAPPQSVTSSYSGNTLSITVSDQGRSISFSVSISGGSGSKSPAIIAYGAPSIPVPNGVATIRFNNDDIAAQQSGSSRGQGKFYNLYGSGHSAGAMTAWAWGVARIIDALEKTPAAGIDPTRVGVTGCSRNGKGAMVAGALEPRIALTIPQESGSGGSACWRISNWQGQQGQNVQTPAQIITENVWLGPVFNNHANNVNALPFDHHQLAGLIAPRALYVIENSDMEWLGWTATYGCMAAARTQWEALGALDNFGFSQVGGNQHCSFNSGKQSAELNAFINKFLLQSGGGTTSILRTERNHGSFNLAEWTPWNVPNLR
What is the function of this protein?
Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin (PubMed:27397104).  Cleaves native lignin-carbohydrate (LC) ester bonds from LC complex preparations of spruce (softwood) and birch (hardwood), containing mainly hemicelluloses with partially acetylated glucomannans in spruce and partially acetylated xylan in birch (PubMed:27397104).  Can hydrolyze benzyl glucuronic acid (BnGlcA), allyl glucuronic acid (allylGlcA) and to a lower degree methyl glucuronic acid (MeGlcA) in vitro (PubMed:28429057).
What are the official names of this protein?
4-O-methyl-glucuronoyl methylesterase 1, Glucuronoyl esterase 1, GE1.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate esterase 15 (CE15) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CTAA_WOLWR
Sequence: MEAKPVAIWLFLCSVMVILMVGIGGFTRLSKAGLSITEWKPITGTLPPLSEQDWLQEKLKYEATPEYKALNYGISMEEFRAIYLIEYIHRLVARLTGLVFVLPFIYFILRRKISKKVVIKLFVALLFGALQAFAGWYMVKSGLVAKPHVSHYRLALHLLLALVIFALLSYQFFDYQIRPQQTKLKVSGNTIYYARMILVLIVIQIIFGAFVAGLNAGLIYNTFPLMDGQIVPEDLFFLQPIWLNIFENRATVQFIHRALALLILTLVVILTVKNASIKPVYIMLLSVVIQIILGVITLLLHIPIAIAIAHQVFSFILFGSSLYFLCYLRKQTTSPICTFFPS
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KDM1B_CAEEL
Sequence: MTTELEIDDRKEEEAQIPGETSESEEGDEPVKMNRVKRACAMAAESLKEAKRIKNMLMEEECVLQLGNCKKTASYGHRLSKTEACCPSCFSVAFRGKDYENEFTIWKQKAMDGQTHVRSEQFVKRYVNSCFLPYYAKCHQCSKYSKLITSDSLSAQQLSDFKCDCASTIESPKIERVREDSEWCFNEFGHPPLLQNNISYDLLVDHYVTRTTGMDATCQEKAALIDNGGIEFRDTRRIMNMFYVPFTDVIANIVHPEFMETDEKFAFPKFADDPISIYYLQVRNTIIAMWLKHPFVELTVKMIEPQIIVRGHARIFFIEHLIHPILEFLTIKGVVNYGAFDFRIDPLNGMRPKIAIIGAGISGISTARHLKHLGIDAVLFEAKDRFGGRMMDDQSLGVSVGKGAQIIVGNINNPITLLCEQIGIKYRNSNFFCPLIDENGRCFTLERKELDDQVDLHYNNVLDAIRNKYQSDRNFPDVPLEVTNFRHFTEMFSKMSSGLLSAADLDSLYTPEFEKLLDFHLGNLEFSCGTHVSNLSAKDYDHNEKFGNFAGEHAVITDGAQRIIDFLATGLDIRLNCPVKCIDWGRDDRKVKIFFENAEQAAEEFDKVVITTSLSVLKSNHSKMFVPPLPIEKQKAIDDLGAGLIEKIAVKFDRRFWDTVDADGLRTEYFGKVSDCKTDRSLFNIFYDFSGKDPNGEDTFVLMSYVTAEHVNLVNVLTESEVADKFCATLRKMFPSAVINPLGHMMSHWGADRFVGMSYTFVPFGSDGDATYNQLKKSIDEKLYFAGEHTIAAEPQTMAGAYISGLREAGQIVMSLKRDSATFE
What is the function of this protein?
Histone demethylase that demethylates di-methylated 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor (PubMed:34329293).  Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (By similarity).  Plays a role in the mitotic development of the germline (PubMed:34329293).  May be involved in H3 demethylation in mitotic cells including gut and embryonic cells (PubMed:34329293).  Plays a role in sensitivity upon interstrand cross-link DNA damage, probably by positively regulating the expression of mlh-1 (PubMed:34329293).  Plays a role in developmental growth and lifespan regulation in response to ultraviolet-induced damage (PubMed:33046905).  No obvious role in larval development, sex chromosome segregation or for regulating meiotic crossover frequency (PubMed:34329293).
What are the official names of this protein?
Lysine-specific histone demethylase 1B homolog, Amine oxidase family member 1, Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.