PharMolix/UniProtQA huggingface dataset:
Protein: SPEA_PASMU
Sequence: MEQVTLTSDGTSSVFAENTVREVCNINYWGMRYYNVDEKGDIFVCPDPDKPQNRVSLAALAEKVQREQGAHLPTLFCFPQIIQHRLRSINQAFKRAREDFGYEGNYFLVYPIKVNQHRRIVESLISSGQPLGLEAGSKAELMAVLAHAGITQTVIVCNGYKDREYVRFALMGEKLGHKVYLVIEKLSEIQLVLEEAAKLNVKPRLGVRARLASQGSGKWQSSGGEKSKFGLSASQVLSLVQMLKEHECLDCLQLLHFHLGSQLGNIRDVATGVRESARFYVELHKLGVNIQCFDVGGGLGVDYEGNRTQSDCSVNYGLNEYADTVVWGIGQACREHGLPHPTIITESGRGVTAHHAVLVSNVIGVERYKFETLAAPAKDAPSVLHSMWETWVDIQSSREKRSLRSWIHESQFDLSDVHNQYNVGLLNLEQRAWAEQLYLNICHEVGQLFNEKHRSHRTIIDELQERFADKLYVNFSLFQSLPDAWGIDQLFPVCPISNLNQPVSRRAVLLDITCDSDGTIDHYIDGDGITTTMPMPHYEEDNPPLLGFFMVGAYQEILGNMHNLFGDTSTVDVLVHEQDKAYIVDYDEGNTVADMLEYVYLDPKKLLDRYREQIEHSNLPASEAIQFLNELEVGLNGYTYLEDE
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: ARNT_YERPE
Sequence: MKLLKDSGAALLALFFVLVYLLPVNSRLLWQPDETRYAEISREMLQRGDWVVPYFMDIRYFEKPVAGYWFNNISQWIFGDSNFAVRFGSIFSTALSAVLVYWLATLLWRNRSTSVLATLIYLSFLLVFGIGTYAVLDPMISLWLTAAMVSFYLTLKAENWQQKVGAYALLGVACGMGFMTKGFLALAVPVIAVLPIVIQQKRIKDLVVFGPIAIVCAVLLSLPWALAIAQREPDFWNYFFWVEHIQRFAEASAQHKSPIWYYLPILCIGVLPWLGLLPGALFKGWRERATKPELFFLLSWVVMPLLFFSVAKGKLPTYILPCMAPLSLLMAAYATDCANNIRMRALKINGVINLLFGVACALVIVVIGLGLVKDIVAYGPQENQKVWLGVLAFAGWGVTGFITLRNNARNWRWAAACPLLFILLVGYLIPQQVVDSKQPQNFIKNNFSELSSSRYVLTDSVGVAAGLAWELKRSDILMFSEKGELTYGLAYPDSQDNYISNDDFPTWLAQARKEGDVSLVVQLAKNEALPAHLPPADKVNLMNRLALLWYQKTP
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTRA_MYCTU
Sequence: MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP
What is the function of this protein?
Member of the two-component regulatory system MtrA/MtrB.  Binds direct repeat motifs of sequence 5'-GTCACAGCG-3', phosphorylation confers higher affinity.  Overexpression decreases bacteria viability upon infection of human THP-1 macrophage cell line, due at least in part to impaired blockage of phagosome-lysosome fusion (upon infection bacteria usually remain in phagosomes).  Infecting C57BL/6 mice with an overexpressing strain leads to an attentuated infection in both spleen and lungs.  The level of dnaA mRNA increases dramatically.  Binds the promoter of dnaA, fbpD, ripA and itself, as well as oriC, which it may regulate.  Upon co-overexpression of MrtA and MtrB growth in macrophages is partially restored, dnaA expression is not induced, although mouse infections are still attenuated, suggesting that bacterial growth in macrophages requires an optimal ratio of MtrB to MtrA.
What are the official names of this protein?
DNA-binding response regulator MtrA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C71A9_SOYBN
Sequence: MISFTVFVFLTLLFTLSLVKQLRKPTAEKRRLLPPGPRKLPFIGNLHQLGTLPHQSLQYLSNKHGPLMFLQLGSIPTLVVSSAEMAREIFKNHDSVFSGRPSLYAANRLGYGSTVSFAPYGEYWREMRKIMILELLSPKRVQSFEAVRFEEVKLLLQTIALSHGPVNLSELTLSLTNNIVCRIALGKRNRSGADDANKVSEMLKETQAMLGGFFPVDFFPRLGWLNKFSGLENRLEKIFREMDNFYDQVIKEHIADNSSERSGAEHEDVVDVLLRVQKDPNQAIAITDDQIKGVLVDIFVAGTDTASATIIWIMSELIRNPKAMKRAQEEVRDLVTGKEMVEEIDLSKLLYIKSVVKEVLRLHPPAPLLVPREITENCTIKGFEIPAKTRVLVNAKSIAMDPCCWENPNEFLPERFLVSPIDFKGQHFEMLPFGVGRRGCPGVNFAMPVVELALANLLFRFDWELPLGLGIQDLDMEEAIGITIHKKAHLWLKATPFCE
What are the official names of this protein?
Cytochrome P450 71A9, Cytochrome P450 CP1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DUS22_HUMAN
Sequence: MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAFLRRL
What is the function of this protein?
Activates the Jnk signaling pathway.
What are the official names of this protein?
Dual specificity protein phosphatase 22, JNK-stimulatory phosphatase-1, JSP-1, Low molecular weight dual specificity phosphatase 2, LMW-DSP2, Mitogen-activated protein kinase phosphatase x, MAP kinase phosphatase x, MKP-x.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISA_BACSU
Sequence: MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGFSGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVNGEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKEKRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVVRQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWDYAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYSGAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIEKTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTSSSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY
What is the function of this protein?
Putative site-specific recombinase having a very important role in sporulation.  It probably plays a role in the recombination of SpoIIIC and SpoIVCB to form sigma K factor.
What are the official names of this protein?
Putative DNA recombinase, Stage IV sporulation protein CA.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the site-specific recombinase resolvase family.
Protein: HIUH_MOUSE
Sequence: MATESSPLTTHVLDTASGLPAQGLCLRLSRLEAPCQQWMELRTSYTNLDGRCPGLLTPSQIKPGTYKLFFDTERYWKERGQESFYPYVEVVFTITKETQKFHVPLLLSPWSYTTYRGS
What is the function of this protein?
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
What are the official names of this protein?
5-hydroxyisourate hydrolase, HIU hydrolase, HIUHase, Transthyretin-related protein.
What is the protein family that this protein belongs to?
Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
What are the subcellular locations of this protein?
Peroxisome.
Protein: PRMA_BRUMB
Sequence: MAQSRLFFSADKAEAERTYNILEQAFEDDGFPIAITEIDEDRQIFEVSVYVEDDAEEVAARVDALVGPGLFDTEELPDIDWVTHSLEGLKPVRAGHFFVHGSHDRDKIEPGDIAIEIDAGLAFGTGHHGTTAGCLELIEETVETEHPTNALDLGTGSAVLAIAIARLAPIPILATDIDPIAVTVAAENAAKNGVAEHIVTATAEGFGHPIFRSYSPFDLIVANILANPLIELAPSIKEHLAPGGSIILSGILDSQHDAVLAAYQTQGLTHQKTLHREGWVAIHLK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_RICCN
Sequence: MLRILNMNEYISLNHYLILSSLVFTIGMFGLFMHRKNIINILMSIELMLLAVNINFVAFSIYMQELSGQIFSIIILTVAAAETSIGLAILLIYFRNKGSIEITDINQMWG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYAY_HAEIE
Sequence: MNIAEFHQNIEHVWQKIEEELENQGADVDCETQGSVFTITFDNRTQIVINKQEPLLELWIASKLGGFHFAFKNGEWVSNDGQRFWDCFVEACAAHGENVQF
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: PSTB1_STRPF
Sequence: MMTEPILQIRDLSVYYNQKKTLKDVSLDLYPNEITALIGPSGSGKSTLLRSINRMNDLNPEVTITGSIVYNGHNIYSPRTDTVDLRKEIGMVFQQPNPFPMSIYENVVYGLRLKGIRDKSILDHAVESSLKGASIWNEVKDRLHDSAVGLSGGQQQRVCIARVLATSPRIILLDEPTSALDPISAGKIEETLLLLKKDYTLAIVTRSMQQASRLSDRTGFFLEGDLLECGPTKAMFMNPKRKETEDYISGKFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: THIC_METM5
Sequence: MTQMTDAKSGITTEEMKFVAKEEGMDVETFKNLIAKGYVVIPKNVNRNTKPVGIGDNLRTKVNVNLGTSPDFIDIACELKKVEISNKYGADAIMDLSTGGNLPEIRKEIIKNTNLPIGTVPIYEVGADAKAKYGRVIDMDEDLIFNVIERQAKEGVDFMTLHCGITKQTVSALNNDPRKMGVVSRGGAFLTAYIMYHDKENPLYKEFDYLLELLKEHDVTLSLGDGMRPGCLQDNTDRAQIQELITLGELVDKCREKGVQVMVEGPGHVPYNNIEANMKIQKTLCKNAPFYVLGPIVTDLAPGYDHITAAIGGTLAAVSGANFLCYVTPAEHVRLMKEDDVKEGLIASKIAAQAADVAKGHSIAWKLEKEMADARMKHDWEKQFEIALDSDKPGKMREEIPSKDEKACSVCGDYCALLMVEELGKR
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: BIOB_CARHZ
Sequence: MFNRIVALTQKVLDGGQINQIEALELAQAEGADILILAAMAAKIREKYVGDKVELCSIISVKTGHCPEDCAFCAQSVHHHTEITPTEMLEEEKILAKAKAMEAAGAHRFDLVTAGLGMTEEDEDFKKILAIYKRLRQEVKLELCACLGTLTEKAAMQLREVGVTRYNHNLETARSFFSNIVTTHTYDERIETIKNVKKAGMEVCCGGIIGMGETMEQRIEFAFTLKELDVDAIPINVLNPIKGTKLENRPLLSPLEVIKTFAIFRFILPDKNIRYAGGREVNLRDMQALGLMAGLNGMLIGHYLTTKGREVETDLQMIRDLGLKI
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: USPD_ECO57
Sequence: MAYKHIGVAISGNEEDALLVNKALELARHNDAHLTLIHIDDGLSELYPGIYFPATEDILQLLKNKSDNKLYKLTKNIQWPKTKLRIERGEMPETLLEIMQKEQCDLLVCGHHHSFINRLMPAYRGMINKLSADLLIVPFIDK
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein D.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C1332_XYLFT
Sequence: MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIVDGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFTGRESESMRPLAIDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMDVDISDAISLSVAVSNLAKVFDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQHGTDLISMLLRAEEEGQKLTHDEIVSNVILLLLGGYETTSNMIGNALIALHRHPKQLARLKSDLSLMPQAVLECLRYDGSVQFTIRAAMDDVSIEGDVVPRGTIVFLMLGAANRDPAQFTDPDHLEITRKQGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVNALIADLH
What are the official names of this protein?
Putative cytochrome P450 133B2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: FEN_METPE
Sequence: MGVALREVLTEYKHPRTWETLAGTAAIDGNNALYQFLSIIRQPDGTPLMNSEGRITSHLSGVFFRTLRFLEKGIRPVYIFDGKPPALKQETIESRREVRREAGVQWEAALARGDQEEAYKQARASSRVTPEIIATSKELLTLMGVPCVQAPSEGEAQAASMAASGAVTYAVSQDYDSLLFGAPLLVRNLTVSSKRRVQGRTIAVQPESIRLDEVLGGLGITREQLIEAGILIGTDFNPGIRGVGPKTALKIVKKDGFADMIAEKLPDFDPSPILQFFRSPPVIANLSLDWQPPDQAGIEDLLCGEYGFATERVRTALQKISGPPGQKTLDRWF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: CLCA3_HUMAN
Sequence: MVFSLKVILFLSLLLSPVLKSSLVTLNNNGYDGIVIAINPSVPEDEKLIQNIKEMVTEASTHLFHATKQRAYFRNVSILIPMTYKSKSEYLIPKQETYDQADVIVADLYLKYGDDPYTLQYGQCGDKGQYIHFTPNFLLTNNLATYGPRGKVFVHGWAHLRWGVFDEYNVDQPFYISRRNTTEATRCSTRITVYMVLNECKGASCIARPFRRDSQTGLYEAKCTFIPKRSQTAKESIVFMQNLDSVTEFCTEKTHNKEAPNL
What are the official names of this protein?
Calcium-activated chloride channel regulator family member 3, Calcium-activated chloride channel family member 3, hCLCA3.
What is the protein family that this protein belongs to?
Belongs to the CLCR family.
What are the subcellular locations of this protein?
Secreted.
Protein: LFTR_SHESA
Sequence: MNSLSFLNHEFEAFPSPELALTDPNGLLAIGGDLRPERLLTAYYHGIFPWFNADDPILWWSPDPRAIFIPGQVNISTSLRKYLKKQPWRFTINHAFTDVMAGCAQPRRKQAGTWITHEIQMAYRELHHNGHAHSVEVWHGERLIGGLYGIAIGQVFCGESMFHRETNASKAAMAVLQQHLIKMNFKLIDAQVMNPHLESLGAKPVKRADFIQLLTQFRDKPVNPAAWIPSEVTLEL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRUF_HALJT
Sequence: MGSGKDRTLAGWTLPETKTDATAQFDRFVTENRFTIAVVFPLVGAVTLLASAEGLLPDPLAFNPYFVLFGTFVMRLPLVAGIFPLVDRRAGLALVALTLYSYGIELVGVRTGWPYGEFTYGVDLGPMLLGDVPFGLPVFFFPLVLNAYLLVLLLLGNRAASTTVRLLSTLATVMLVDLVLDPGAVAIGFWIYEMPQFYGVPWQNYAGWLLSGSVAVLLFDFGFDRAGLRRRLRDCPFMLDDLVSFVLLWGGINLFYTNWVPFGLAALLGAGLLWTDRFDFDLSETRLGRAVWR
What is the function of this protein?
Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR).  Catalyzes the reaction that introduces hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin (BABR) to generate BR.
What are the official names of this protein?
Bisanhydrobacterioruberin hydratase.
What is the protein family that this protein belongs to?
Belongs to the BABR hydratase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NU2M_PARLI
Sequence: MHQMISIFLFLTVVSGTIIVVSAENWFVIWLGLELSTLALIPILWFCFTPRNIEATIKYFLVQAFSAALLLNSALIQAWFSGSWSALIPMESFPSLCLSVALAFNLGLAACHFWLPDVLQGLPFIQGLIIATWQKIAPLFLLFYFNQLNFSYFIILAALISILVGGWGGLNQTQTRKILAFSSIGNMGWIVVTSAFSLGTAAMMLFIYLVINTSIFLILDFLSIFTLGHLNNTSQLSPISITLVILTILSLGGLPPLTGFILKFSSLYSLINNGFIFFSSVMIIGSLLSLFFYLRIAFNTTLILFPQHLISLTAWRNSTEAEPLMAKTWLVSSFSVLSILAIPLTIPLYINV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DESII_STRVZ
Sequence: MTAPALSATAPAERCAHPGADLGAAVHAVGQTLAAGGLVPPDEAGTTARHLVRLAVRYGNSPFTPLEEARHDLGVDRDAFRRLLALFGQVPELRTAVETGPAGAYWKNTLLPLEQRGVFDAALARKPVFPYSVGLYPGPTCMFRCHFCVRVTGARYDPSALDAGNAMFRSVIDEIPAGNPSAMYFSGGLEPLTNPGLGSLAAHATDHGLRPTVYTNSFALTERTLERQPGLWGLHAIRTSLYGLNDEEYEQTTGKKAAFRRVRENLRRFQQLRAERESPINLGFAYIVLPGRASRLLDLVDFIADLNDAGQGRTIDFVNIREDYSGRDDGKLPQEERAELQEALNAFEERVRERTPGLHIDYGYALNSLRTGADAELLRIKPATMRPTAHPQVAVQVDLLGDVYLYREAGFPDLDGATRYIAGRVTPDTSLTEVVRDFVERGGEVAAVDGDEYFMDGFDQVVTARLNQLERDAADGWEEARGFLR
What is the function of this protein?
Involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics.  Catalyzes the SAM-dependent deamination of dTDP-4-amino-4,6-deoxyglucose (dTDP-viosamine) to yield dTDP-3-keto-4,6-deoxyglucose.  It can also catalyze the oxidative dehydrogenation of the non-physiological substrate dTDP-D-quinovose to dTDP-3-keto-6-deoxy-d-glucose.  It can also deaminate dTDP-3-amino-3,6-deoxyglucose.
What are the official names of this protein?
dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase, dTDP-D-quinovose dehydrogenase, dTDP-D-quinovose:S-adenosyl-L-methionine 1-oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. DesII family.
Protein: NAAT1_DROPE
Sequence: MELKGVHQQNGTSNGTGAVGAEGESAPPTAPATAEAAASLETTTEKVDAEQQKPERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFATICIITYYSSLLALTLYYLFVSFQSVLPWSYCWEEWMNCVDSRPQEDTDALLLSSSNVTNVTALTDTVKLQSSSELYFLNVVIKEKMDISDGIGDPDWKLTLALFVSWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFILLVRAVTLEGARDGIIFFLEPQWGELLNPTVWKNAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTILCDQFKSWKYWKVALATSICGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWIYGMQNFCDDVEFMCNRRVSLYWRVCWSFFTPVMMIVIFIYSMVTIEPITYSEQFFPEAGNVAGWLLFGIGAAQFPLWWMWYISQHREGSLGQSFVASLRPSDKWGPANPETKRQWVIFKNEKAAQRATKKQSSKLGAFWQKLGHFCGSNT
What is the function of this protein?
Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids.  Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).
What are the official names of this protein?
Sodium-dependent nutrient amino acid transporter 1.
What is the protein family that this protein belongs to?
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UBXN4_HUMAN
Sequence: MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM
What is the function of this protein?
Involved in endoplasmic reticulum-associated protein degradation (ERAD).  Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).
What are the official names of this protein?
UBX domain-containing protein 4, Erasin, UBX domain-containing protein 2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Note=Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.
Protein: RS181_MYCBP
Sequence: MAKSSKRRPAPEKPVKTRKCVFCAKKDQAIDYKDTALLRTYISERGKIRARRVTGNCVQHQRDIALAVKNAREVALLPFTSSVR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: SMN_CANLF
Sequence: MGGGGGLPEPEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDISEASDKPKSTPKRKPAKKNKSQKKNATTALKQWKVGDKCSAVWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNVSDLLSPACEVANNVEQDTQENENESQISTDESENSSRSPGNKPNNIKSKAAPWNSFLPPPPPMSGSGLGPGKPGVKFSGPPPPPPPPHFLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFKQNQKEGRCSHFN
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.  Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits.  Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development.  Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination.  May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
What are the official names of this protein?
Survival motor neuron protein.
What is the protein family that this protein belongs to?
Belongs to the SMN family.
What are the subcellular locations of this protein?
Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with actin and at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. Colocalizes with FMR1 in cytoplasmic granules in the soma and neurite cell processes (By similarity).