PharMolix/UniProtQA huggingface dataset:
Protein: SRCN1_HUMAN
Sequence: MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF
What is the function of this protein?
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration.  Regulates dendritic spine morphology.  Involved in calcium-dependent exocytosis.  May play a role in neurotransmitter release or synapse maintenance.
What are the official names of this protein?
SRC kinase signaling inhibitor 1, SNAP-25-interacting protein, SNIP, p130Cas-associated protein, p140Cap.
What is the protein family that this protein belongs to?
Belongs to the SRCIN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Presynapse. Postsynapse. Postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions.
Protein: TPIS_SALA4
Sequence: MRHPLVMGNWKLNGSRHMVNELVANLRKELTGVAGCDVAIAPPEMYIDLAKRAAAGSHIMLGAQNVDLNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLKEQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKADAKIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGASLKADAFAVIVKAAEAAKQA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M1_I34A0
Sequence: MSLLTEVETYVLSIIPSGPLKAEIAQRLEDVFAGKNTDLEVLMEWLKTRPILSPLTKGVLGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDKAVKLYRKLKREITFYGAKEVALSYSTGALASCMGLIYDRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVATTNPLIRHENRMVMASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: SECA_XYLFT
Sequence: MINSLLTRLFGSRNERQLRQLNSIVAKINALEAELQKLSDTALQAKTTEFKQSIQDGKSLDKLLPEAFAVCREASRRVLGMRHYDVQLIGGMVLHLGKIAEMRTGEGKTLVATLPVYLNALAGKGVHVVTVNDYLARRDAAHMGRLYNWLGLSVGVVYPGMPHSDKHAAYGADITYGTNNEFGFDYLRDNMALSKADRYQRGLHYAIVDEVDSILIDEARTPLIISGPADESPDLYIRVNRIIPHLTRQENEEAEGDYWVDEKGKQVHLSEVGMERAEDLLRQAGILEEGDDSLYAAQNLSVVHHLNAALRAHALYQRDVDYIVRDGEVVIVDEFTGRTLAGRRWSDGLHQAIEAKEGVPVQRENQTLASITFQNLFRIYKKLSGMTGTADTEAYEFQSIYGLEVMVIPTNRPTVRKDYPDQVFLNRSSKFNAVLEDIKDCAKRGQPVLVGTTSIEISEMLSEHLRKARVKHEVLNAKQHEREATIVANAGLPGAVTIATNMAGRGTDIVLGGSLDTVLAELDPDATEEDRFRVKTAWNRRHEAVKAAGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDSLMRIFASEWVQKVMRLMGMKEGDVIEDRRVTRQIERAQRKVEAHNFDIRKNLLDYDDVNNEQRKVVYAQRDELLDAESIKENIDSIRHEVIDALVTRFVPEHSIDEQWDLPGLQATLQSEWGLHLPLIEMLKGREEVDAERIAFLVQDAVDKHCAEREASIGAETMRALEKHVMLTVLDQGWKEHLATMDYLRQGIHLRGYAQKQPKQEYKREAFELFSEMLEHVKREVIASLARVRIRSEEEMAALEEQERRQVDTLLRQSQFQHQEAGGYGTGDEAVSLQRQPAGQRAAIAQVIRDTPKVGRNDPCPCGSGKKYKHCHGLVT
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RNC_KLEP3
Sequence: MNPIVINRLQRKLGYTFHHQELLQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNTLAEIAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQNVERLILSWYQTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_LACE2
Sequence: MGKIIGIDLGTTNSCVAVMEGGKPVVIANAEGLRTTPSVVAFSKTGERLVGDPAKRQAVTNADKTISSIKRHMGTDYKVEIDGKKYTPQEISAMILQKLKSDAENYLGEKVTEAVITVPAYFNDAQRQATKDAGKIAGLDVKRIINEPTAAALAYGLDNEHEQKIMVYDLGGGTFDVSIIEIGDGVIEVLATAGNNKLGGDDFDNAVTQYMLNDFKAKEGVDLSKDTMALQRLKEAAEKAKKELSSTTQTEINLPYITATAEGPKHFEMTLTRAKFDELTHDLVEKTAEPVKNALSDAGLTASELSKVLLVGGSTRIPAVQDKVKSLTGHEPSKTLNPDECVAIGASIQGGKLAGDAGAGDILLLDVTPLSLSIETMGGIATRLIERNTTIPTKKSQIFSTAADNQTAVDINVVQGERQFARDNKSLGQFRLDGIPPARRGVPQIEVTFDIDANGIVNVSAKDLGTGKEQHITITAGSNMSDEDIDKAVKEAAEFEAQDKKRKDAIDARNEADSMVFQTQKAMDEAGDKLDASDKAAVETDLNALKALVDGSDPENMTDAQVDEIKAAKEKLMESAQKLFAKLYESQQAAGGAGPDMGAGAGPDMGAGASNGSAPYGDDVVDGDYKEV
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RECO_ALKEH
Sequence: MSGDRVLVQPAWVLHRRPWSESSLIVELFSRDFGRIGAVARGGRNSRRWRGLLEPFSPVLASWQGRGELRSLVAAEPDGARPALAGAALASGFYLNELLLRLLRRDDPHPELHPLYGDTLNRLPDEAALRGFECRLLEALGYGLLLLEDMGGEPVHGEAHYRYHLEHGPERLAAVPEAGEGLLVRGRTLLALAGREALAGPSLPEARRLMRAALSLYLGDRPLQSRALYRQLARTPRAATPASPNDH
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: MTNA_PICGU
Sequence: MTTLEAIKFDRTNVTLQILDQLLIPYSTEYLNIEGVDDAYDAIKSMQVRGAPAIAIVGSFAIVVEIKNRHISSIDELAAKIDYLESSRPTAVNLSNACNEIRALLGNSESLDEVYKRVFDFAVALYDDDLSNNHKIGSNGVDYLVESLRSQNFEGPFSIITYCNTGSLATSGHGTALGIVRSAYKALSKENSKEKFWLEQIYPCETRPYNQGAKLTTFELKYEKIPFTLICDNMVTSLISRTHNKKQVKDIVAPVKFAIVGADRIVQNGDTANKIGTFQLAAIFDSFNRRNTGPRDSLKMIVAAPRTTIDLKTTTGDDIIIEERPANELTTLKGPILRKDVAGEKQIVGVATPGIQVWNPAFDVTPHELIDSIVTEEKVYAKDKEGNYHL
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATPB1_DINSH
Sequence: MPADPEVHFEGTIVAIRGGVVDVAFAEAVPRIHALIVAGGVAMEVASIVGEGVVRCIALGPTRGLGLGTRATGTRAGIEVPVGEGVLGRMLDMFGAPLDGAPPPEATARRPIHRPPPVLSDRVLRAEVLETGIKAIDLLSPIERGGKTGLFGGAGVGKTVLLSELIHNTVEHHHGVSLFCGIGERSREAEELWREMGEAGVRERMVMLFGQMNEAPGVRFLVGHSALTMAEYFRDDREQDVLLLIDNIFRFVQAGSEVSGLLGRMPSRVGYQPTLATELAALQERIASTRRGAITSIQAVYVPADDFTDPAAAHIFSHLSASVVLSRKRASEGLYPAVDPLASTSVMLTPEVVGQRHYDIARGVRRTLAEYEDLRDIIAMLGIEELSAHDRAVVARARRLERFLTQPFFTVGAAAGTLGKLVPIAETLDGCEEILSQTSFERPESAYYMIGALSDLRKEAAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 1, ATP synthase F1 sector subunit beta 1, F-ATPase subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DDL_XANP2
Sequence: MAKHVAVLMGGWSSEREVSLRSGAACAGALEAAGYRVTRVDVGRDVAEVLTHLKPDVAFNVLHGQPGEDGTIQGILEILRIPYSHSGVLASALAMDKAQARIMLAAAGVPVAKGGLVSRAEAAKAHIMPTPYVLKPNAGGSSVGVFIVREDQAHPPQELTREDWPHGENLLAEEFIPGLELTCAVMGDKVLDVIEIESTQKFYDYESKYAPGGSQHILPARILPEIYQRVQMLSLTAHRALGCRGVSRSDFRFDPSRGDGSGLICLEVNTQPGMTETSLVPELAAHAGISFGELVTWMVEDASLER
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M1_I37A0
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDKAVKLYRKLKREITFHGAKEVALSYSAGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: DGTL1_AZOC5
Sequence: MAVSGARPRMTWACDPVWTRGRLVPEQEGTRSAFRRDCDRIIHSTAFRRLKHKTQVFVFHEGDHYRTRLTHTLEVAQIARSIARALGLDEDLAEALALAHDLGHPPFAHAGERALDACMADYGGFDHNAQSLRVVTRLERRYAGFDGLNLTWETLEGIAKHNGPLTDRSGKPLGAAGDVLPHAIVAHSAVQDLELWTHAGPEAQVAAISDDIAYDVHDLDDGLRAGLFHLDELEALPLVGAVLAEVRASWPSLETGRVIHEVMRRLITRFVEDVVRETETRARAAKVRSSFDVRMAGAPLVAFSAGMRTAEAAVKGFLFPHMYRHARVNRIMDEAQGVVRDLFALFMARPQEMPADWQLEGAPPERMARRVADYIAGMTDRYALDQHARFFDTTPELR
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: RLMC_SHELP
Sequence: MKCAYFDANQCLSCRHLKTPLSDQVAAKTATLAALLKDLSVEQWLPPVVGPESGFRNKAKMVVLGAAHQPILGLVSPSGEAVSLCDCSLYPQDMQQLLHRLEAFVRQAGIPPYRVDKAKGELKFILLTRSQVRGEYMLRFVMRSEQAIPRIERELPRLLAEHPEIKVVSVNLQPVHMAILEGEEEIFLTEATRLEEEFNGVPLYIRPKSFFQTHPEVAAKLYLSARKWTRELAPTSIWDLFCGVGGFGLHCASKEVALTGIEIEAEAIACAKMSAETLGLDKVRFTALDSTSFASDSRGEEKPELIIVNPPRRGIGEALCHSLSEFAPKAILYSSCNPKTLAKDLHCISGYRVTKVQLFDMFPHTDHFEVLVMLQRIGE
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: ISPH_BEII9
Sequence: MTDKPKLHILLCAPRGFCAGVVRAIDAVEQALRLYGAPVYVRHEIVHNKFVVEGLKAKGAIFVEELDEVPDTDKPVIFSAHGVPKSIPAEAQSRNIFAIDATCPLVTKVHREAELHHNNGRQVLLVGHAGHPEVVGTLGQLPEGSILLVQTPGEIETLQVKDEKNLAYVTQTTLSVDDTRNMVEALTKRFPEIIGPHREDICYATTNRQEAVKRIAPIVDALLVVGSSNSSNSQRLREVAERSGCKLARLVLRADDVEWDLFSNISSLGITAGASAPEVLVEEIMAAFAERFELEVETVSTADEGVFFPLPRELRQAAS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: ROQD_PENRW
Sequence: MTVSSTVQPLKACVPEATEAADMPHHTLSKSMTFANLDQYQYWHAVGPMLGRMLSNGSYSIHKQYEYLCLFAHVIIPKLGPFPGGRDIYKCLLGGTGSVELSQNVQKLGLTARVAFEPTSYIASTGVDPLNRHTVHATLVELRAIGSASIDMELHQMLVNELTLTDREERLMSPEAISGTAWKTQILLALDLGQTGITIKEYFYPALKASVTGQSVAKLCFSAIRKVDKQGRFEPASKAIETYMKTQSQTDLYFLSCDLVDPAATRIKLYLMELDMRLAKVEEHWTMGGKLNDEETLLGLKMLQELWVEFGIIEGMRNEPERPSLPGDPDTIVPFIMNYEMSPGEALPKPKFYFPLVGIPELKIANVLTAFFERYGMPEQAAVYRNNLQTPSKDLVIATDHQAWLSFSYTKKKGPYLTMYYH
What is the function of this protein?
Roquefortine prenyltransferase; part of the gene cluster that mediates the biosynthesis of the mycotoxins roquefortine C and meleagrin (PubMed:22118684, PubMed:23776469).  The first stage is catalyzed by the dipeptide synthase roqA which condenses histidine and tryptophan to produce histidyltryptophanyldiketopiperazine (HTD) (PubMed:22118684, PubMed:23776469).  HTD is then converted to roquefortine C through two possible pathways (PubMed:23776469).  In the first pathway, prenyltransferase roqD transforms HTD to the intermediate roquefortine D, which is in turn converted to roquefortine C by the cytochrome P450 monooxygenase roqR (PubMed:23776469).  In the second pathway, HTD is first converted to the intermediate dehydrohistidyltryptophanyldi-ketopiperazine (DHTD) by roqR which is then prenylated by roqD to form roquefortine C (PubMed:23776469).  Roquefortine C can be further transformed to meleagrin via three more reactions including oxydation to glandicolin A by roqM, which is further reduced to glandicoline B by roqO (PubMed:23776469).  Finally, glandicoline B is converted to meleagrin by the glandicoline B O-methyltransferase roqN (PubMed:22118684, PubMed:23776469).  More studies identified further branching and additional metabolites produced by the roquefortine/meleagrin cluster, including roquefortine F, roquefortine L, roquefortine M, roquefortine N and neoxaline (PubMed:24225953).
What are the official names of this protein?
Roquefortine prenyltransferase roqD, Roquefortien/meleagrin synthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: PIHD1_RAT
Sequence: MADSKLLAPELSDAESMGEETVRFQELLLKASKELQQAQTARPESTQIQPKPGFCIKTNSSEGKVFINICHSPSIPPPVDVTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSNFYLRMQNSDFLRELVVTIAREGLEDKYGLQLNPEWRMLKYRSFLGSISQQSIRSQQRPRIQELGTLDTHDSLGTRHGPERPHLNLWLEAPDLLLAEVDLPKLDGAQGLALEIGENRLVVGGPQQLYHLDACIPLRINSEASRAAFHHRRKQLMVSMPLLSASS
What is the function of this protein?
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity).  Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity).  Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity).  Positively regulates the assembly and activity of the mTORC1 complex (By similarity).
What are the official names of this protein?
PIH1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PIH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSHD_JONDD
Sequence: MTTVLLTSTSGPLSDDAARSVRELVALETERLGVPPLSEQPLLNLRDPRARVVHIMDTQGGDVTGYAQLDVSREGGSLELTARCADRTQCVGALLNEAELIAQDHDVVVRPWVHGDDPDVTRVLAQRGYVPARTLLVLSRDLSLADTQALATPVVPEGFVCRRFDPISDADSLLAANSDAFSWHPEQGRLTHHDLSMRMKEPWFTPDHLHVVTPVSESARIVGFVWLKAEPHSRSIELYVLGVTEAAQGQGVGRFLTELATVTALNQGYPRLHLYVEADNTRALALYTQHGFAPMERHVNFTQPTGELGHEPPS
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: RAG1_CHICK
Sequence: MSITSRMDLPEEIQHPYAKFSEWKFKLFKVRPFQKEPSDKSQCINKDQEQEVASTDKNITLHKDEEVPRGEKLILTQKDFMGNTQALEKDVNDMKIQDNTAHQNNLKQLCRICGVSFKTDCYKRTHPVHGPVDDETLWLLRKKEKKATSWPDLIAKVFKIDVRGDVDTIHPTRFCHNCWSIIHRKFSNTPCEVYFPRNSTMEWQPHSANCEVCHTPSRGVKRKSQPPNVQHGKRVKIIAERARVNRGIKNQVIKNKNVMKEITNCKNRHLSTKLLAVDYPADFIKSISCQICEHILADPVETTCRHLFCRTCILSCIRVMGCYCPSCWYPCFPTDLVTPVKSFLNILDSLSIRCPVPECDEEILHGKYGQHFSNHKEMKDKELYNPINKGGRPRQHLLSLTRRAQKHRLRELKRQVKAFAEKEEGGDIKAVCMTLFLLALRAKNEHKQADELEAIMQGRGSGLHPAVCLAIRINTFLSCSQYHKMYRTVKAVTGRQIFQPLHALRTAEKALLPGYHPFEWKPPLKNVSTNTEVGIIDGLSGLPLSIDDYPIDTIAKRFRYDTALVSALKDMEEEILEGMKAKNLDDYLNGPFTVVVKECCDGMGDVSEKHGSGPAVPEKAVRFSFTVMNIAIDHENERIRIFEEVKPNSELCCKPLCLMLADESDHETLTAILSPLIAEREAMKNSELLLEIGGILRTFKFIFRGTGYDEKLVREVEGLEASGSTYICTLCDATRLEASQNLVFHSITRSHAENLERYEIWRSNPYHESVDELRDRVKGVSAKPFIETVPSIDALHCDIGNATEFYRIFQMEIGEVYKNPDATKEERKRWQLTLDKHLRKKMKLKPMMRMSGNFARKLMSKETVEAVCELIKCEERHEALKELMDLYLKMKPVWRSSCPAKECPELLCQYSYNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWASEGNESGNKLFRRFRKMNARQSKFYEMEDVLKHHWLYTSKYLQKFMNAHKTLRSQGFAIDPDDGLGDSLPPEISLESNDSVEL
What is the function of this protein?
Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination.  V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments.  In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment.  RAG2 is not a catalytic component but is required for all known catalytic activities.  DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.  In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3.  Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity).
What are the official names of this protein?
V(D)J recombination-activating protein 1, RAG-1.
What is the protein family that this protein belongs to?
Belongs to the RAG1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRD_DECAR
Sequence: MLYPLIRKFFFSLDAETAHGIGMKGIDLMNAAGLACAVAKPVAACPVEVMGLKFPNPVGLAAGLDKNGDHIDGLAKLGFGFIEIGTITPRPQDGNPKPRLFRIPEAQGIINRMGFNNAGVDKLLENVRAAEFPKKGGILGINIGKNATTPIEKAADDYLICLDKVYNDASYVTVNISSPNTKNLRELQKDEALDDLLAQLKAKQLQLAEQYGKYVPMALKIAPDLDDEQITAIADALRRHRFDAVIATNTTLSREGVEGMPNATETGGLSGKPVFEKSTAVQKKLSIALAGELPIIGVGGIMGGEDAAEKIRAGASLVQFYSGFIYRGPDLVSEVAETLAHVMRKSV
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RECF_GEOKA
Sequence: MFLTNLTLTNYRNYEYETLNFGEGVNVILGENAQGKTNMMEAIYVLAMAKSHRTSNDKDLIRWNEEYAKIEGRAEKRSGSLTLELLISKKGKKARCNHIEQQRLSQYVGHLNVVMFAPEDLNLVKGSPQVRRRFVDMEIGQVSPVYIHDLSQYQKLLQQRNHYLKMMQARERSDEAVLDVLTEQLVLLAAKITLRRRQFLSLLEQWAMPIHYEISRGAEQLCIRYEPSVDVSEKAELSRIVEAYSETFAAMREREVQRGTTLVGPHRDDIAFFVNGKNVQTFGSQGQQRTTALAVKLAELELIFSELGDYPILLLDDVLSELDDFRQTHLLDAIRKKVQTFVTTTSIDGIKHDIIQEAAIYRVHSGSVTAPS
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUTP_SALTY
Sequence: MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAIFLSGISESWIAIGLTLGAWINWKLVAGRLRVHTEFNNNALTLPDYFTGRFEDKSRVLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATIIYTFIGGFLAVSWTDTVQASLMIFALILTPVMVIVGVGGFSESLEVIKQKSIENVDMLKGLNFVAIISLMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNNNPALAGAVNQNSERVFIELAQILFNPWIAGVLLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKSASQQELVWVGRVMVLVVALIAIALAANPDNRVLGLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGAVTVIVWKQYGWLDLYEIIPGFIFGSLGIVIFSLLGKAPTAAMQERFAKADAHYHSAPPSKLQAE
What is the function of this protein?
Catalyzes the sodium-dependent uptake of extracellular L-proline.
What are the official names of this protein?
Sodium/proline symporter, Proline permease.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HTPX_PROA2
Sequence: MKRIVLFLLTNFAVILVLSISARLLGVDRFLTSNGLNMGMLLAFAALIGFGGSFISLMMSKTMAKWSTGARVIERPGNQDEAWLMDTVRQLSKKAGFPMPEVAVFDGAPNAFATGPSKSKSLVAVSTGLLQSMNRKEVEAVLAHEVAHIQNGDMVTLTLIQGVVNTFVIFLARALAYVVDNFLRGDEKESSGPGIGYWVSSIAFEIMFGILASIVVMFFSRKREYRADAGAAALMGERRSMIDALRVLGGLEAGALPKEMAASGIAGGGMMALFSSHPPIEARIAALESAR
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.