PharMolix/UniProtQA huggingface dataset:
Protein: DNAJ_CERS1
Sequence: MAKRDYYEVLGVSRTASADELKKAYRTKAKELHPDRNADNPQAEAQFKEVNEAYDVLRDADKKAAYDRYGHAAFEGGMGGGARAGGGYGQQGDFASAFSDVFEDLFGDFMGGRGGAPRSRAQRGSDLRYNLRVTLDEAYRGVQKTINVPASVACDACKGTGAEGGAEAVTCPTCSGMGKVRAQQGFFTVERTCPTCNGMGQIVKNPCKVCHGAGRVEKERSLSVNIPAGVETGTRIRLAGEGEAGMRGGPSGDLYIFIEVREHALFQRDGVHLFCRVPVSITAAALGGEVEVPTIDGGSSRVKIPAGSQTGKQMRLRGKGMPALRGGGAGDMLIELAVETPVNLTARQKELLREFEKLSEDNNPEGKSFFSKVKGFWDGMTG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAP1_MOUSE
Sequence: MAAHVWLAAALLLLVDWLLLRPMLPGIFSLLVPEVPLLRVWVVGLSRWAILGLGVRGVLGVTAGAHGWLAALQPLVAALSLALPGLALFRELAAWGTLREGDSAGLLYWNSRPDAFAISYVAALPAAALWHKLGSLWAPSGNRDAGDMLCRMLGFLGPKKRRLYLVLVLLILSCLGEMAIPFFTGRITDWILQDKTVPSFTRNIWLMSILTIASTALEFASDGIYNITMGHMHGRVHREVFRAVLRQETGFFLKNPAGSITSRVTEDTANVCESISGTLSLLLWYLGRALCLLVFMFWGSPYLTLVTLINLPLLFLLPKKLGKVHQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKTLNKKEALAYVAEVWTTSVSGMLLKVGILYLGGQLVIRGAVSSGNLVSFVLYQLQFTQAVQVLLSLYPSMQKAVGSSEKIFEYLDRTPCSPLSGSLAPSNMKGLVEFQDVSFAYPNQPKVQVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGQCLVQYDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLNRTPTMEEITAVAVESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPLLLILDDATSALDAGNQLRVQRLLYESPKRASRTVLLITQQLSLAEQAHHILFLREGSVGEQGTHLQLMKRGGCYRAMVEALAAPAD
What is the function of this protein?
ABC transporter associated with antigen processing.  In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules.  Uses the chemical energy of ATP to export peptides against the concentration gradient.  During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen.  Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules.  Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle.  As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation.
What are the official names of this protein?
Antigen peptide transporter 1, APT1, ATP-binding cassette sub-family B member 2, Histocompatibility antigen modifier 1, Peptide transporter TAP1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
Protein: OGT_SULIY
Sequence: MLVYGLYKSPLGYITVAKDDKGFIMLDFCDCVEGNSRDDSSFTEFFHKLDLYFEGKPINLREPINLKTYPFRLSVFKEVMKIPWGKVMTYKQIADSLGTSPRAVGMALSKNPILLIIPCHRVIAENGIGGYSRGVKLKRALLELEGVKIPE
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUR7_YEAST
Sequence: MVKVWNIVLRLVVLLFLAGNTLLLILMIISGATDHYPVNRFYWVQGNTTGIPNAGDETRWTFWGACLQDKDGSDTCTSNLAPAYPISPVDNFNTHINVPHQFISKRDAFYYLTRFSFCFFWIALAFVGVSFILYVLTWCSKMLSEMVLILMSFGFVFNTAAVVLQTAASAMAKNAFHDDHRSAQLGASMMGMAWASVFLCIVEFILLVFWSVRARLASTYSIDNSRYRTSSRWNPFHREKEQATDPILTATGPEDMQQSASIVGPSSNANPVTATAATENQPKGINFFTIRKSHERPDDVSV
What is the function of this protein?
Involved in sporulation and affects the sphingolipid composition of the plasma membrane.  Probably involved in endocytosis.
What are the official names of this protein?
Protein SUR7.
What is the protein family that this protein belongs to?
Belongs to the SUR7 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes at eisosomes, structures which colocalize with sites of protein and lipid endocytosis.
Protein: RS2_CARHZ
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMAEYIFTDRNGIYIIDLQKTAKKLEEAYSFVRELSAQGGTILFVGTKKQAQDAIKEEAERCGMFYVNQRWLGGTLTNFKTIRKRVERLIEIEKMEQEGALSVLPKKEVAKILKEKEKLSRFLSGIKEMKKLPDALFVVDPRKEKIAVAEARKLDIPVVAIVDTNCDPDEVDYVIPGNDDAIRAVKLITSKIADAVIEGRQGEQYAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: MACR_PENTR
Sequence: MPLSEPRQIKKPRLSLSCIVCRRRKVRCGREQPECANCVRMKENCVYRTMVRDESTGRVRPVSPQDKDSRVSTSDARPDLPWPHWGRDTNAPYPDKPSRPPSRPQVSANASPSPQRQEPYPTVPSWEEAIQLPSYRDANAPQINGSSTTTRDPSPAPSTSLFPTPSDHPCRDYLSIRRGGRVRYVGQTFWGFVAGKESLSDDFFDENRHAHPDLPLPHISSMGMFNLLRSLPTKPVSDTLLETFFLAVWPLVPLLHPPSLQADYDEFWEWCRNSENALPSDKLRDDPTLICLLFAVLYCGASAAPAATWANTNLQGLQKETTVSHLKSAYTTSLSLCQHQEHPTLNTLVSNLLTGPFLDRPFEPMRSLVNVSTTVRIAQTMGLHREGAWSALSSVDREIRRRVWWHIVWLDVQSSISTGLTPCCGNEALDAVGMVGTDHVEPSNIPAGLSPPNELVTNRQSVAMLYAIGRFQTARLQARIVAHLQSAHDPSQDGFGELITDSKELLQKIDSLIARVPTQGIPEMGYIPSRLANASPSTQPLLYKDDPSQPTVFSAWTRIMLTLLKSEMAILLQKPFLPPPDSANPQSLKSWTSMAQLCVNYLRIYLQLYQAPAFSPYAWFCCSHYGPLQCVFITLMYLHYFQHSGETTLARYCVDEVIHHCVAQYQAPDPSSTRTSPDDTDSNGGKLRMPLAIQVLVDLHERLDSSLGPEDRAPPLDLIECQARFSMSHLATKASDLRATSDQPSSDVSSTTRTHHNCETPPITTGAPPVAAGNKPVPPNSVFVAGSDSGLDMDFLATISDLEAWSSSLILESDNLLARPDDMTPDHAVITRLGSQSTASGRRGLPDGLDFPG
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of macrophorins, isoprenoid epoxycyclohexenones containing cyclized drimane moieties.
What are the official names of this protein?
Transcription factor macR, Macrophorins biosynthesis cluster protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: ANMK_BACC0
Sequence: MYIAGVMSGTSLDGIDVALVRIEGSGVESKVELIHFTTVPFCNDIKSEIQQALSIENSNVQLICSLNFKLGLCFANAVKEVCKEANFSLEQLDLIGSHGQTIYHQPKQDGNRIPSTLQIGEPAVIAYETNTTVISNFRTMDMAAGGQGAPLVPYSEVILYRDPSKNRLLQNIGGISNVTVIPNQQSDQNVIAFDTGPGNMIIDEVCQRLFQLSYDQNGEIAKQGRVVDEILTYCMSHPFLKMNPPKSTGREQFGEKFASELLKRFEKHSKENILTTVTMFTANSIVHHYKKFILPYYEIDEVILGGGGSYNSTLVEMLRNGLKDENCAIFIQEDIGYSSEAKEAIAFAILANETHHCNPSNVPSATGAKQSVVLGNITFPPV
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: TPSDB_ABIGR
Sequence: MALLSIVSLQVPKSCGLKSLISSSNVQKALCISTAVPTLRMRRRQKALVINMKLTTVSHRDDNGGGVLQRRIADHHPNLWEDDFIQSLSSPYGGSSYSERAVTVVEEVKEMFNSIPNNRELFGSQNDLLTRLWMVDSIERLGIDRHFQNEIRVALDYVYSYWKEKEGIGCGRDSTFPDLNSTALALRTLRLHGYNVSSDVLEYFKDQKGHFACPAILTEGQITRSVLNLYRASLVAFPGEKVMEEAEIFSASYLKEVLQKIPVSSFSREIEYVLEYGWHTNLPRLEARNYIDVYGQDSYESSNEMPYVNTQKLLKLAKLEFNIFHSLQQKELQYISRWWKDSCSSHLTFTRHRHVEYYTMASCISMEPKHSAFRLGFVKTCHLLTVLDDMYDTFGTLDELQLFTTAFKRWDLSETKCLPEYMKAVYMDLYQCLNELAQEAEKTQGRDTLNYIRNAYESHFDSFMHEAKWISSGYLPTFEEYLKNGKVSSGSRTATLQPILTLDVPLPNYILQEIDYPSRFNDLASSLLRLRGDTRCYKADRARGEEASAISCYMKDHPGSTEEDALNHINVMISDAIRELNWELLRPDSKSPISSKKHAFDITRAFHHLYKYRDGYTVASSETKNLVMKTVLEPVAL
What is the function of this protein?
Involved in defensive oleoresin formation in conifers in response to insect attack or other injury.  Involved in monoterpene (C10) olefins biosynthesis.
What are the official names of this protein?
Limonene/alpha-pinene synthase, chloroplastic, (-)-(1S,5S)-alpha-pinene synthase, (-)-(4S)-limonene synthase, Agg-pin2.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUOB_ECOHS
Sequence: MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLNDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIGKERRPLSWVVGDQGVYRANMQSERERKRGERIAVTNLRTPDEI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LPTE_ECOLU
Sequence: MRYLATLLLSLAVLITAGCGWHLRDTTQVPSTMKVMILDSGDPNGPLSRAVRNQLRLNGVELLDKETTRKDVPSLRLGKVSIAKDTASVFRNGQTAEYQMIMTVNATVLIPGRDIYPISAKVFRSFFDNPQMALAKDNEQDMIVKEMYDRAAEQLIRKLPSIRAADIRSDEEQTSTTTDTPATPARVSTTLGN
What is the function of this protein?
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.  Required for the proper assembly of LptD.  Binds LPS and may serve as the LPS recognition site at the outer membrane.
What are the official names of this protein?
LPS-assembly lipoprotein LptE.
What is the protein family that this protein belongs to?
Belongs to the LptE lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: PCKA_SHEB8
Sequence: MADGLNRVHFNPSTAQLVEFALLRGEGELTANGALVAKTGARSGRSPGDRFIVREPSSEAEIEWGPVNQAFDPGAFEGLWARVEAYLADKELFVSDLEVGADTEHYQPVRVTTQYAWHQLFARNLFIIPEEFNRKDKPVWQIINAPDFVCDPARDGTNSDATVILNFAERKVLLAGLKYAGEMKKSMFSVQNFLLPAQGVLPMHCSANVGKDGDTTLFFGLSGTGKTTLSADPKRFLIGDDEHGWAPGGVFNIEGGCYAKCIDLSQKNEPVIWDAIRFGTVLENVVMDEHRVPNYKDSSLTENTRAAYPLEHIAQRKEDNCGAEPHAVVFLTCDVSGVLPPVSILTKEQAAYHFLSGYTAKVGSTEIGSTSAIQSTFSTCFGAPFFPRPAGVYAELLMKRIESFGSQVYLVNTGWTGGPHGVGKRFDIPTTRAIVDAIVSGELKDVETVHLDTLNLAVPVAVTGVDSNLLNPINTWSDKALYAEYAQKLAEAFTKNFAKYQVSDAIRNAGPKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_PROM9
Sequence: MKNQKKLIILTGPSGVGKGTVIKEILGKDKNIWLSISATTREPREGEQEGENYYFLKQEKFKEMIEKNLFLEWAQFAGNYYGTPLSSVNEKITKGFTVLLEIEVEGAKQIKEKFPESLSIFLLPPDKAELERRIRNRGTEKEEAIKKRLLRASYEISASNQFDFELTNHNVDETAKRIIKLIQT
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_EDWI9
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGIGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVVRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: YQGF_UREPA
Sequence: MRKLALDLGTKSCGFAISDLLGIIASGLDNFIYEENDFTAVLAKIDEIMINYHHEIDTIVLGYPTNVYDGSKNERTYLIESFYALLKQHFLNHEKIKIVYEDERFSTKIATQRLKNSCVKAAKIKKVKDKMSAVVILESYLSKNHFN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAI1_BOVIN
Sequence: MRMSPVFACLALGLALIFGEGSASYQPQSAAASLATDFGVKVFQQVVRASKDRNVVFSPYGVASVLAMLQLTTGGETRQQIQEAMQFKIEEKGMAPAFHRLYKELMGPWNKDEISTADAIFVQRDLELVHGFMPNFFRLFRTTVKQVDFSEVERARFIVNDWVKRHTKGMISDLLGEGAVDQLTRLVLVNALYFNGQWKMPFPESNTHHRLFHKSDGSTISVPMMAQTNKFNYTEFTTPDGRYYDILELPYHGNTLSMLIAAPYEKEVPLSALTSILDAELISQWKGNMTRLTRLLVLPKFSLETEIDLRRPLENLGMTDMFRPSQADFSSFSDQEFLYVSQALQKVKIEVNESGTLASSSTALVVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
What is the function of this protein?
Serine protease inhibitor.  Inhibits TMPRSS7.  Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).  As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots.  As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading.  Acts as a regulator of cell migration, independently of its role as protease inhibitor.  It is required for stimulation of keratinocyte migration during cutaneous injury repair.  It is involved in cellular and replicative senescence (By similarity).  Plays a role in alveolar type 2 cells senescence in the lung (By similarity).  Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
What are the official names of this protein?
Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ADRB3_MACMU
Sequence: MAPWPHGNSSLVPWPDVPTLAPNTANTSGLPGVPWAAALAGALLALAVLATVGGNLLVIVAITRTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLVLTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRWELGRFPPEESSPALSRSLAPAPAGTCAPPEGVPACCRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPDPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCHCGGRLPREPCAADRPASSPRAPLRPGPAPRSPGFASGSTGLLGEFLRPEGQEATLR
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  Beta-3 is involved in the regulation of lipolysis and thermogenesis.
What are the official names of this protein?
Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CBP1_THEAQ
Sequence: MTPEAAYQNLLEFQRETAYLGSLGALAAWDQRTMIPRKGHGHRARQMAALARLLHERATDPRIGEWLEKVEGSSLVEDPLSDAAVNVRAWRRAYERARAIPERLAVELAQARSEGETAWEALRPRDDWQGFLPYLKRLFALAKEEAEILMAVGPDPLDPPYGELYDALLDGYEPGARARDLEPLFRELSSGLKGLLDRILGSGRRPDVGVLHRHYPKEAQRAFALELLQACGYDLEAGRLDPTAHPFEIAIGPGDVRITTRYYEDFFNAGIFGTLHEMGHALYEQGLPEAHWGTPRGEAASLGVHESQSRTWENLVGRSLGFWERFFPRAKEVFSSLADVRLEDFHFAVNAVEPSLIRVEADEVTYNLHILVRLELELALFRGELFLEDLPEAWREKYRAYLGVAPRDYKDGVMQDVHWSGGMFGYFPTYTLGNLYAAQFFAKAQEELGPLEPLFARGEFTPFLDWTRRKIHAEGSRFRPRALVERVTGSPPGAQAFLRYLEAKYGALYGF
What is the function of this protein?
Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues, but not Pro.
What are the official names of this protein?
Thermostable carboxypeptidase 1, Carboxypeptidase Taq.
What is the protein family that this protein belongs to?
Belongs to the peptidase M32 family.
Protein: RL25_XANOM
Sequence: MAKTHEIKAERRADEGKGASRRLRHAGVIPAIVYGGELEPVSIQLNHEQIWLAQQNEWFYSSILDLNLNGDVQQVLLRDIQRHPFKQLIMHIDFQRVSANQKLSAAVPLHFINEEASPAGKSSEVVVTHELNEVQVVCLPKDLPEFIEVDLGALEVGNVIHLSEIKLPAGVEIPELKLGKERDVAVVAAKHVRIQEEDAAGEEGSEGAETK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: LEU3_CHLTE
Sequence: MMYKIVSIPGDGIGPEVVAGALDVLNAVAKKHGFEVSVEEHLFGGASYDVHGSMLTDETLEACKNCDAVLLGAVGGYKWENLPHDKKPEAALLKIRKELGLFANLRPARVYDALVASSTLKTEVVQGTDFMVFRELTGGIYFGQPRGYDETRGWNTMVYERYEVERIARLAFEYAQKRGNAKVTSIDKANVLEVSQFWRNIVHEVHQDFPEIELVDMYVDNAAMQVVRNPKQFEVIVTSNLFGDILSDISGMITGSLGMLPSASIGSEHALYEPIHGSAPDIAGQNKANPIATIASVAMMFENSFNRPEVAADIYAAIEGALAAGFRTGDIAAAGEAISSTTEMTAAIVARI
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD5R1_SPECI
Sequence: MGTGLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKGQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPANQLSGSQTGVSSSVKKAPHPSVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYVGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQAFSDLKNESGQEDKKRLLLGLDR
What is the function of this protein?
p35 is a neuron specific activator of CDK5.  The complex p35/CDK5 is required for neurite outgrowth and cortical lamination.  Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling.  Activator of TPKII.  The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.
What are the official names of this protein?
Cyclin-dependent kinase 5 activator 1, CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1.
What is the protein family that this protein belongs to?
Belongs to the cyclin-dependent kinase 5 activator family.
What are the subcellular locations of this protein?
[Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, neuron projection. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. SUBCELLULAR LOCATION: [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus. Cytoplasm, perinuclear region. Perikaryon. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.
Protein: PERA_ECO27
Sequence: MLTSKKEMQSSENKQEENLALLLTNYISYQNIVIFTGGNQFKIRNKKEFTEYTIESNSLFFLAKNTHWDMEIVGIDNSNPYRKIIIDDALIKLLHSISSDDSCYVKKKIFTANLNEMQLNIVSNIITDIKYSGNNKKIFKILYLLSFFNDYNDIVNVILSASSKSIVDRVIKVIELDISKNWKLGDVSSSMFMSDSCLRKQLNKENLTFKKIMLDIKMKHASLFLRTTDKNIDEISCLVGFNSTSYFIKVFKEYYNTTPKKYNGVYSITQGTLP
What is the function of this protein?
Could help in the transcriptional activator of eaeA expression in enteropathogenic E. coli.  However, it seems that it is PerC which acts as an activator.
What are the official names of this protein?
Transcriptional activator PerA.
Protein: AGRF4_MOUSE
Sequence: MKPWIAMVCCLVFFLTTECSHSKPKTHRKDEDKFQISLQKHEFRPRQGKCDGLCSSSSSCNQSCPWNFRGEIVFTCNQNKWQKTIETCTSLSVDTLFQRIHPAASLSLASSSVFPMSLIGNAAPVHIGNVFQGIQKYCPEDYVCIVDAVKSSAVTSGNIAFIVELLKNISSNLQTSGIHDNVNWKKMKNYGKVANHILGPTAISNWAFIANKNASSDLLESVNSFAKKLQIQGKSESIVDELFIQTKGSRISHSSSEHSLSLSVPRYNATEDVLVVIEIPRQALQELSFNASQAIVVAFPTLGAILKEVHRPNTSLQKPIDDLILSLVLPEGLNEIILTFDKINKSQSTSSQCVSWDPATGQWDESPCTVMSDINSTVKCRCRHTKAVTSFSILMSSKPVKNTILNHITFIGLSISIFSLVLCLVIEAIVWSRVVVTEISYMRHVCIVNIAVSLLTANVWFIIGSNFSANVQEDHKWCVAVTFLCHFFFLSLFFWMLFKALLIVYGILVVFRRMMKSRMMAIGFAIGYGCPLVIAVITVTVTEPGEGYTRKDACWLNWNQTKALFAFAIPALAIVAVNLLVVLAVAINTQRPLIGSSKSQDMAIVFRISKNVAILTPLLGLTWGFGLTTLLEGVHLVFHIIFALLNAFQGFFILLFGTIMDHKIRDALRMRVSSLKGKSRAAEKVSLSPANGSRILNR
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Adhesion G protein-coupled receptor F4, G-protein coupled receptor 115.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AROD_STRP1
Sequence: MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFTLRTVQEGGNITLSSQEYVDIIKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNFEETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNYTRGFKTLNPEQEFATISMGKLGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: RPOZ_YERPG
Sequence: MARVTVQDAVEKIGNRFDLVLVAARRARQIQSGGKDALVPEENDKVTVIALREIEEGLITNQILDVRERQEQQEQQAAEIQAVTAIAEGRR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.