PharMolix/UniProtQA huggingface dataset:
Protein: WDR4_BOVIN
Sequence: MASSAGLALCGHALVVRGGSRLLATSTSSSDGDSLFIYDCSAAEKKSQENKGEDGQPVDQGSDTVLASTFSKSGSYFVLTDDSKRLILFRTNPWQCLSVRTVVRRCTALTFTASEEKILVADKSGDVYSFSVLEPHGGGRLELGHLSMLLDVAVSPDDRFVLTADRDEKIRVSWAAAPHSIESFCLGHTEFVSRIFVVPNHPELLLSSSGDCTLRLWEYRSGRELHCCPLTSLQEPTEPWSDKRFAVSRITYWSQEDCVALSCDGLPVVYIFQLDAAQRQLVPRQLLTFQHRVWDAAFEEGHGLWVLQDCREDPLVLYRPVGGQWQSAPESAELRRVCAHVRVNWAMLEGCAGVDSGFSSLYKATCDNMTTYLKKKEERLQQQLEKKRRQAPPPGPNGPTKKMRAGELAQGCSS
What is the function of this protein?
Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs).  In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding.  Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop.  M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay.  Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs.  Also required for methylation of a specific subset of miRNAs, such as let-7.  Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, WD repeat-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes at the site of nascent DNA synthesis.
Protein: MIAB_SHIB3
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLDATHSYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGSTGSFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_BURP6
Sequence: MAITMRQMLEAGVHFGHQTRFWNPKMAPFIFGHRNKIHIINLEKTLPMYNDALKYVRQLAANRGTILFVGTKRQSRDTIAQEALRAGMPYVNARWLGGMLTNFKTLKVSIKRLKDMEAAVEAGELEKMSKKEALLFEREIAKLQKSIGGVKDMGGIPDAIFVVDVGYHKIAVTEANKLGVPVIAVVDTNHSPEGVDYVIPGNDDSSKAVALYAQGVADAILEGRANAVNEVVQAVRGDDEYVEENA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: NCB5R_ASPNC
Sequence: MSAFSPENITGAFIPSALFVAGTFFFKQELTPFAVALAAVLVGWKVFSNKPRKVLNPGDFQHFTLKEKNDISHNVTVYRFALPRPTDILGLPIGQHISLAATIGGKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKYLTTLEVGQTMKVRGPKGAMVYTPNMCRHIGMIAGGTGITPMYQIIKAIIRNRPRNGGNDTTQVDLIFANVNPDDILMKDELEQLAKEDDGFRIYYVLNNPPEGWTGGVGFVTPDMIKERLPAPSSDIKVLLCGPPPMVSAMKKATESLGYTKARPVSKLEDQVFCF
What is the function of this protein?
NADH-dependent reductase for dph3 and cytochrome b5.  Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase, predominantly cbr1.  By reducing dph3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex.  The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
What are the official names of this protein?
NADH-cytochrome b5 reductase 1, Microsomal cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: RS20_LATSS
Sequence: MPQIKSAMKRVKTIEKANNRNASQLSTMRSAIKKFKAAQAAGNEEAADLLKAATRAIDMASTKGLIHANKAGRDKSRLNKMMAK
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: TAT_HV1RH
Sequence: MEPVDPRLEPWKHPGSQPKTACNNCYCKKCCYHCQVCFLTKGLGISYGRKKRRQRRGPPQGSQTHQVSLSKQPTSQPRGDPTGPKESKEKVERETETDPAVQ
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: FLIE_BUCAP
Sequence: MFIDNIYDQNIYTNIDFLDTNKQKNKKSNNFINHFQKALGEISNIQNNSKKNIEKFQSNHSDISLNDIMINLQKSSISIELAIQVRNRIISAYKEIMNQQI
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: ECFA2_STRMU
Sequence: MGINLQEVSYTYQAGTPFEGRALFNVSLEIKDGSFTAFIGHTGSGKSTIMQLLNGLNTPTEGTVLVDDVAIRSDSKNKDIKNIRKKVGLVFQFPESQLFDETVLKDVAFGPQNFGISKEEAEKLAREKLAMVGISEELFEKNPFELSGGQMRRVAIAGILAMEPSILVLDEPTAGLDPKGRRELMTLFKELHQGGMTIVLVTHLMDDVSNYADWVYVLEKGRIVLSGSPKSVFQEIEFLESKQLGVPKITQFAAHLRERGITFDALPITLEEFVEAIKNG
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CCND1_CHICK
Sequence: MEHQLQCCEVETIRRAYLDANLLNDRVLQTMLKAEETCSPSVSYFKCVQKEILPYMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSFEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPDELLQMELLLVNKLKWNLAAMTPHDFIEHFLTKMPLAEDTKQIIRKHAQTFVALCATDVKFISNPPSMIAAGSVVAAVQGLHLGNTNTFLSYQCLTHFLSQVIKCDPDCLRACQEQIESLLESSLRQAQQHNVSSETKTVEDEADLSCTPTDVRDVNI
What is the function of this protein?
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.  Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.  Hypophosphorylates RB1 in early G(1) phase.  Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
What are the official names of this protein?
G1/S-specific cyclin-D1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: AMIE_GEOSE
Sequence: MRHGDISSSHDTVGVAVVNYKMPRLHTKKEVIENAKNIANMIVGMKQGLPGMDLVIFPEYSTMGIMYDRKEMFETATTIPGPETEIFAEACRKANTWGVFSLTGEQHEEHPHKNPYNTLVLINNKGEIVQKYRKIIPWCPIEGWYPGDTTYVTEGPKGIKISLIICDDGNYPEIWRDCAMKGAELIVRCQGYMYPAKEQQIMMAKTMAWANNVYVAVANATGFDGVYSYFGHSAIIGFDGRTLGECGEEENGIQYAEISLSQIRDFRQNAQSQNHLFKLLHRGYTGIIQSGEGDKGVAECPFDFYRTWVMDAEKARENVEKITRTTIGTAECPIEGIPHEGKEKEASV
What is the function of this protein?
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.
What are the official names of this protein?
Aliphatic amidase, Acylamide amidohydrolase, Wide spectrum amidase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: CYDK_THEKO
Sequence: MLDLVVIGHVSIDTLIFPDGRRVTMPGGAAAGVATSAALAGAKVGLVTKIGTDFPKEWLQALSSVLDISGVQILPGKTIHIQMIYHEDGSVDAPVEMGVAQKMGEIPIPEEYLDAKVFHISPIPPEEQLKLLNRLKGKRVTVDFNPTYKEEYIKRRDLLREIVSRVEIVFPNEREALMITGAEDVKDAARILHGWGAKLVVITRGEKGVLVYDGSFREFPALPIKPEEIVDPTGGGDAFAGGFLAGYSRGRPLEECVRLGLERAREVLKKWGDWSITV
What is the function of this protein?
Involved in nucleoside degradation.  Phosphorylates cytidine to CMP.  Can also act on deoxycytidine and uridine, but is most active with cytidine.  ATP is the most preferred phosphate donor, but it can also use GTP, CTP or UTP.
What are the official names of this protein?
Cytidine kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: YIHI_ECOL5
Sequence: MKPSSSNSRSKGHAKARRKTREELDQEARDRKRLKKRRGHAPGSRAAGGNTTSGSKGQNAPKDPRIGSKTPIPLGVAEKVTKQHKPKSEKPMLSPQAELELLETDERLDALLERLEAGETLSAEEQSWVDAKLDRIDELMQKLGLSYDDDEEEEEDEKQEDMMRLLRGN
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: INSC5_ECOLI
Sequence: MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsC for insertion element IS2I.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: TRSF_DROME
Sequence: MKMDADSSGTQHRDSRGSRSRSRREREYHGRSSERDSRKKEHKIPYFADEVREQDRLRRLRQRAHQSTRRTRSRSRSQSSIRESRHRRHRQRSRSRNRSRSRSSERKRRQRSRSRSSERRRRQRSPHRYNPPPKIINYYVQVPPQDFYGMSGMQQSFGYQRLPRPPPFPPAPYRYRQRPPFIGVPRFGYRNAGRPPY
What is the function of this protein?
Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl.  Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins.  Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site.  No known function in males.
What are the official names of this protein?
Female-specific protein transformer.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Speckled subnuclear compartment.
Protein: SYGA_LISW6
Sequence: MNLQTMIRTLQDYWSEQGCIMLQSYDVEKGAGTMSPYTFLKAIGPEPWKAGYIEPSRRPADGRYGENPNRLFQHHQFQVVMKPSPDNIQELYLGSLEKLGINPLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECFPVTSEITYGVERLASYIQDKENVFDLEWTEGISYRDIFFQAEFENSTYAFETSNTDMLLTLFDTYEREAARQMQEGLVFPAYDYVLKCSHTFNLLDARGVVSVTERAQYIGRIRNLARRVAKTFYESREKLGFPLVKEEGGKRHE
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECOT_YERE8
Sequence: MKRLSIAITSLLMAASASTIAATEPPLNQQQPLEKIAPYPQAEKGMSRQVIFLEPQEDESRFKVELLIGKTIEVDCNRHMLGGNLETRTLSGWGFDYLVMDKISEPASTMMACPDNTRRPQFIAANLGDAAMQRYNSRLPIVVYVPQGVDVKYRIWEAGKDVRSAQVK
What is the function of this protein?
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
What are the official names of this protein?
Ecotin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YBG5_YEAST
Sequence: MVDLMTVIMVRYSLFLTWELVLLQLLLLRLSFHVSRTKILVLVRISIILHHDENAYTQSQYNLYTGPLTLRFLQRVYYMHFHIYIFNAIPLRYVKKNDPMSGPSYEMRYNKNER
What are the official names of this protein?
Putative uncharacterized protein YBL065W.
Protein: RUBR_CUPNH
Sequence: MNDAGMGRFEGSYLGDRGRLAADARLECKICWWEYDPEVGDPVWQIAPGTSFSALPAHWRCPNCDGEAEQFMVLGPQA
What is the function of this protein?
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide.  Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.  Could be involved in hydrogenase-linked redox processes.
What are the official names of this protein?
Rubredoxin, Rd.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
Protein: RL15_NEIG1
Sequence: MFLNTIQPAVGATHAGRRVGRGIGSGLGKTGGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFKSLTVSANAQLRLSELESIAVNEIDILVLKQAGLIASTVSNVKVIASGEISKAVALKGIKVTKGARAAIEDVGGKIEM
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PTN3B_BACSU
Sequence: MKLLAITSCPNGIAHTYMAAENLQKAADRLGVSIKVETQGGIGVENKLTEEEIREADAIIIAADRSVNKDRFIGKKLLSVGVQDGIRKPEELIQKALNGDIPVYRSATKSESGNHQEKKQNPIYRHLMNGVSFMVPFIVVGGLLIAVALTLGGEKTPKGLVIPDDSFWKTIEQIGSASFSFMIPILAGYIAYSIADKPGLVPGMIGGYIAATGSFYDSASGAGFLGGIIAGFLAGYAALWIKKLKVPKAIQPIMPIIIIPVFASLIVGLAFVFLIGAPVAQIFASLTVWLAGMKGSSSILLALILGAMISFDMGGPVNKVAFLFGSAMIGEGNYEIMGPIAVAICIPPIGLGIATFLGKRKFEASQREMGKAAFTMGLFGITEGAIPFAAQDPLRVIPSIMAGSMTGSVIAMIGNVGDRVAHGGPIVAVLGAVDHVLMFFIAVIAGSLVTALFVNVLKKDITASPVLSETAPTSAPSEAAAANEIKQPIQSQKAEMSEFKKLTDIISPELIEPNLSGETSDDIIDELIQKLSRRGALLSESGFKQAILNREQQGTTAIGMNIAIPHGKSEAVREPSVAFGIKRSGVDWNSLDGSEAKLIFMIAVPKESGGNQHLKILQMLSRKLMDDNYRERLLSVQTTEEAYKLLEEIE
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in mannose transport.
What are the official names of this protein?
PTS system mannose-specific EIIBCA component, EIIBCA-Man, EII-Man.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIR1_CAEEL
Sequence: MQRYNSTYVVKRDGRKEDVHFDKITSRIQKLSYGLNMDFVDPVAVAIKVISGLYKGVTTVELDNLAAETAASMTTQHPEYALLAARIAVSNLHKKTNKVFSEVMKTLHEFHHPHTGKHAPMISDETWAIIEKNADKLNSAIVYDRDYSYTYFGFKTLERSYLLKINKEIVERPQQMLMRVSIGIHGDDITSAIETYNLMSERYMTHASPTLFNSGTCRPQMSSCFLLTMSEDSILGIYDTLKQCALISKSAGGIGLNVHKIRATGSVIAGTNGTSNGLIPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHADIFEFVSLRKNTGPEEERARDLFLALWIPDLFMKRVEKDQEWSLMCPCECPGLDDCWGEEFEALYAKYEAEGRVRKTVKARKLWEHIVSNQIETGLPYITYKDAANRKSNQQNLGTIKCSNLCTEIIEYSAPDEIAVCNLASIALNRYVTPEKKFDFVKLAEVTKVITRNLNKIIDVNYYPVEEARNSNMRHRPIGLGVQGLADCFMLMRYPFTSAEARDLNKRIFETIYYAALEASCELAELNGPYSTYEGSPVSKGQLQFDMWGVTPTDQCDWATLRKKIAKHGIRNSLLMAPMPTASTAQILGNNESIEPYTSNIYSRRVLSGDFQIVNPHMLKDLVERGLWTDEMKNRLIANNGSIQNIDGIPSDIKELYRTVWEISQKDIIEMAADRGAYIDQSQSLNIHMAKPSYAGITSMHFYGWKKGLKTGMYYLRTKPAVNAVQFTVDKNALKTNQQAETPATVAESQDEGCLMCSG
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase large subunit, Ribonucleotide reductase large subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: AGTR1_SHEEP
Sequence: MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGLFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASGSVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPPFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCTEVE
What is the function of this protein?
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney.  The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
What are the official names of this protein?
Type-1 angiotensin II receptor, Angiotensin II type-1 receptor, AT1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLD_TERTT
Sequence: MSALILDGKALAQKTEAELSERVAALKSKTGRTPILATILVGGDPASATYVRMKGNACTRIGMDSMKVELPETTTTDELLAKIAELNNNPDVHGILLQHPVPSQIDERACFDAIDLSKDVDGVTCLGFGRMAMGEEAYGCATPKGIMRLLEAYEIPLEGKHAVVVGRSPILGKPMALMLLNANATVTICHSRTKDLQSHIATADIVVGAVGIPEFIKADWIKPGAVVVDAGYHPGGVGDIELGPLADKASALTPVPGGVGPMTINTLIYQSVDSGEKKLA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: OTC_BOVIN
Sequence: MLFHLRTLLNNAALRNGHNFVVRNFRCGQPLQDKVQLKGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTDDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDLLAKEASIPIVNGLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQVATPKGYEPDPSITKMAEQYAKENGTKLSLTNDPLEAACGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAAPDWTFLHCLPRKPEEVDDEVFYSPRSLVSPEAENRKWTIMAVMVSLLTDYSPQLQKPKF
What is the function of this protein?
Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline.  The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.
What are the official names of this protein?
Ornithine transcarbamylase, mitochondrial, OTCase, Ornithine carbamoyltransferase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ARGR_RENSM
Sequence: MSAESAAIVQPIALIPATKTARQARIAALLTAQSVRSQAELAALLADDGVQVTQATLSRDLVELGAVRVRADGGLVYAVPQAGVDRTPHAAVSKEYLDARMTRLCAELLVTAEASANLVVLRTPPGAANFLAMAIDHSVLPDILGTIAGDDTVLVIARDPFGGAAIAERFLQFAEEPGT
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_HISS2
Sequence: MAGAKEIRTKISSVQSTQKITKAMEMVAASKMRKTQDRMSSSRPYSKAIQGVISHISKANIDYQHPFLIEREVKNVGILIISTDRGLCGGLNVNLFKTALSEIKNWKEQNVDVSLGLIGAKGIGFFQSLGLKIKAQHSGMGDTPVAEELIGIANRMFEAYKEGKIDAIYVTYNKFINTMSQKPIMEKLVPLPELDNDSLGKNSDNWEYIYEPNPQTLLDSLLVRYLESQVYQAVVENLASEQAARMVAMKAATDNAGNLINDLQLVYNKARQASITNELNEIVAGAAAI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: OXLA_BOTJA
Sequence: ADDKNPLEECFRETDYEEFLEIARNGLKATSNPKRVV
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:18346051).  Is highly active on L-Leu, L-Met, moderately active on L-Arg, L-Trp, L-Phe, L-Val, L-His, and L-Ile, and is weakly or not active on L-Cys, L-Lys, L-Ala, L-Thr, L-Asp, L-Ser, and L-Pro (PubMed:18346051, PubMed:19101583).  Exhibits diverse biological activities, such as hemorrhage, edema, apoptosis of vascular endothelial cells or tumor cell lines, as well as regulation of platelet aggregation.  Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation.  These different effects are probably due to different experimental conditions (By similarity).  This protein induce hemolysis and has antibacterial and antiparasitic activities (against the Gram-positive S. aureus).  Tested in vivo, this protein significantly inhibits Ehrlich ascite tumors growth and induces an influx of polymorphonuclear cells, as well as spontaneous liberation of hydrogen peroxide from peritoneal macrophages.
What are the official names of this protein?
L-amino-acid oxidase, BjarLAAO-I, LAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YFJT_BACSU
Sequence: MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLISMLDDLEAKYERFKKDWE
What are the official names of this protein?
Uncharacterized protein YfjT.