PharMolix/UniProtQA huggingface dataset:
Protein: LKHA4_ASPFU
Sequence: MTTVVNLPRDPNTLSNYNNWVSTHITANFDILFDQRKLAGNVIHRFRSTTDGESNHIILDTNHLDIGSVKVNGQPSEWEYLPRLEPYGTPLKIKLDQGVKLNETIEVDISVQTTEKCTALQWLTPAQTSNKKHPYMFSQCQAIHARSIFPCQDTPDVKCTLDFNITSPLPVIASGLPVRGSSEAPKSDGKTLYKFHQKVPIPSYLFALASGDISEAPIGPRSVVATSPDKLGECQWELEADTEKFINAIEKIVYPYVWGEYNVLILPPSFPYGGMENPIFTFATPSIISKDRENIDVIAHELAHSWSGNLVTNASWEHFWLNEGWTTYLERRLRHGEPYRHFSAIIGWKALTDSVEHFGPEHDFTKLITNLKGMDPDDAFSSIPYEKGFNFLFHLENLVGKSKFDRFIPHYFNKYKGKSLDSYEFKSTILDFFKDDSDASTALNELDWDSWFYAPGLPPKPDFDTSLVDVVYDLAKKWLSLPKSSFKPQPEDIRGLTANQVVVFLEQILVSERQLTPELSKLMGEIYGLAASQNIEVANLYFQVGLQAGDASVVEPTADLLGKIGRMKFVRPLYRKLAKFDRKRALDTFEKHKGFYHPICRAMVEKDLFGKKDE
What is the function of this protein?
Aminopeptidase that preferentially cleaves di- and tripeptides.  Also has low epoxide hydrolase activity (in vitro).  Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
What are the official names of this protein?
Leucine aminopeptidase 2, Epoxide hydrolase, Leukotriene A-4 hydrolase homolog, LTA-4 hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CYSD_PSEU2
Sequence: MVDKLTHLKQLEAESIHIIREVAAEFDNPVMLYSIGKDSAVMLHLARKAFFPGKLPFPVMHVDTRWKFQEMYRFRDQMVEEMGLDLITHINPDGVAQGINPFTHGSAKHTDIMKTEGLKQALDKHGFDAAFGGARRDEEKSRAKERVYSFRDSKHRWDPKNQRPELWNVYNGNVNKGESIRVFPLSNWTELDIWQYIYLEGIPIVPLYFAAERDVIEKNGTLIMIDDERILEHLTDEEKSRIVKKKVRFRTLGCYPLTGAVESEATSLTDIIQEMLLTRTSERQGRVIDHDGAGSMEEKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: RIMP_RICFE
Sequence: MQTIEQQITNVIEESLTDMGFELVLVKFKGVNPKVVEILIDSLNGEKISVEDCTKASRTISAILDVEDLIEDAYSLEVASSGLERPLVKFENYNRFLGREVKIKLKELLNGKTRYQGKIIKAKNNKIYLKCEEQEVLIDYDLIKNANLVLTEEVFKKLLKQ
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_PARP8
Sequence: MDKFIVHTGVVAPLDRENVDTDAIIPKQFLKSIKRTGFGPNAFDEWRYLDHGEPGQDNSKRPLNPDFVLNQPRYQGASILLTRQNFGCGSSREHAPWALQQYGFRAIIAPSFADIFYNNCFKNGLLPIVLTEQQVDHLFNETFAFNGFQLTVDLEKQVVRTTDGGTEYPFEVAAFRKYCLLNGFDDIGLTLRHADKIRQYEAERIAKQPWLNNRLVR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RS16_NEIMB
Sequence: MVVIRLARGGSKHRPFYNVIVTDSRSRRDGRFIERVGFYNPVANEKQERVRLNADRLNHWIAQGAQVSDSVAKLIKEQKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: KAE1B_METM6
Sequence: MDISKDLICIGFEGTAEKTGVGIINSKGEVLFNKTIIYTPPVQGIHPREAADHHAETFVKLLKEALAVVPLEKIDLVSFSLGPGLGPSLRVTATTARALSLSINKPIIGVNHCISHVEIGKLKTDAVDPLTLYVSGGNTQVLAYTGKKYRVIGETLDIAIGNCLDQFARHCNMPHPGGVYVEKYAKNGNKFIKLPYTVKGMDISLSGLLTAAMKKYDSKERIEDVCHSLQETSFSMLTEITERALAHTNKAEVMLVGGVAANNRLKEMLNVMCAEQNVDFYVPEREFCGDNGAMIAWLGILQYLNGKRMDLNDTKPISNYRSDMVEVNWIPEENNENIKSRIIPEHLIGKGAEADISKGRYLEFESITKERVKKGYRILELDELIRMRRTVKEARFLTAIKELGIYAPSIFDIDKERKKITMSYIHGKIAKEKIEEGNLDFCEDLGKIIGKMHVGGIVHNDLTTSNFIVSDNTFVIDFGLGKYSDLVEDKAIDLIVLKKSIMSIHYDKFDLVWNKIVEGYKTYEMSESVLECMKEVEKRARYL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  The Kae1 domain likely plays a direct catalytic role in this reaction.  The Bud32 domain probably displays kinase activity that regulates Kae1 function.
What are the official names of this protein?
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_RUTMC
Sequence: MSMSDPIADMLTRIRNAQMVEKKEVNVPASNLKSAIASVMQEEGYIKSFSVDGIAASKTLNIKLKYYDNKSVIEKLKRISKPSLRVYVSSSQMPSVMNGLGIVIVSTPKGVMTGQTAYEQNIGGEVLCSVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RL28_PHOV8
Sequence: MSKICQITGKKAMIGNNVSHSKRRTKRTFDVNLFTKKFYYVEQDCWISLNICANGLRVINKKGLDAALNEAVTKGYCDWKSIKIIG
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: Y1126_HAEIN
Sequence: MSLTRCPECRKKISENAENCPNCGFSFKQKDLEMYKQRLEARRLHNEEVNRKSTKLHIIWFCIFAIFIAVTSWMVN
What are the official names of this protein?
Uncharacterized protein HI_1126.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TRXH_BRACM
Sequence: MAATAELIPAGEVIACHTVEDWNNKLKAAKESNKLIVIDFTAVWCPPCRFIAPIFVELAKKHLDVVFFKVDVDELATVAKEFDVQAMPTFVYMKGEEKLDKVVGAAKEEIEAKLLKHSQVAAA
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide.  The H form is known to activate a number of cytosolic enzymes (By similarity).
What are the official names of this protein?
Thioredoxin H-type, Trx-H.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant H-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_SALSV
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANIGDSYVILKDGEAWLFGANFTPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRINREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDLKEREWQLDKARIMKNAGR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: VKT3_CRYNI
Sequence: MSSGGLLLLLGLLTLWEALTPVSSTDRPEFCELPEDSGPCKGLFHVFYYNSDQNQRLEFIYGGCYGNANNFKTIEECKRTCAA
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Kunitz-type serine protease inhibitor nigrescinin-3.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: PPAC_BACAA
Sequence: MEKVLVFGHKNPDTDAICSAIAYAELKKELGMNAEPVRLGEISGETQFALDYFKVEGPRFVETVANEVDNVILVDHNERQQSANDIESVRVLEVIDHHRIANFETSDPIYYRCEPVGCTATILNKMYKENGVTIRKEVAGLMLSAIISDSLLFKSPTCTEQDVAAARELAEIAGVDADKYGLEMLKAGADLSGKTMEQLISLDAKEFQMGNAKVEIAQVNAVDTNDVLVHQAELEKVISAVVEEKGLDLFLFVVTDILTNDSVGLAIGKAANIVEKAYNVSLENNTATLKGVVSRKKQIVPVLTEAFQA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_GLAP5
Sequence: MQLERLQKKLGYQFANLDYLTQALTHRSAASKNNERLEFLGDSILNFAIGKALYEKFPKANEGELSRMRAALVKEQTLAVVARQFELGEYMKLGAGELKSGGYRRESILSDCVEAIIAAVYLDAGIDRAMERVHCWYQQLLNDMQLGEAQKDPKTRLQEYLQGRKLPLPTYEVIDIKGEAHNQTFKVSCKVEKVDEIFIGNGTSRRKAEQDAALQVIKVLGIK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBT_SYNR3
Sequence: MESFAYILILAFSIGTLFFAIALRDPPKIGK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: NADA_THESQ
Sequence: MVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANHLTPEIIREYREKFPDVPVVLYVNSTSECKALADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPESPKPVRDKADYVGSTGQMEKIPEKDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_AGRVS
Sequence: MDATVKKMSPETSRPSREEAENAVRTLLRWAGDDPSREGLLDTPKRVAKAYGELFGGYNVNVEDVLGTTFEEVGGYNDIVLVRDIPFFSHCEHHMLPVIGKAHVAYLPNGRVLGLSKIARVVDLFARRLQTQETMTAQIADSLVQYLQPRGVAVMVDAEHMCMAMRGIQKSGSTTLTTTFTGEFKTDVPQQVRFMTMVQNR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: SGM_MICZI
Sequence: MTAPAADDRIDEIERAITKSRRYQTVAPATVRRLARAALVAARGDVPDAVKRTKRGLHEIYGAFLPPSPPNYAALLRHLDSAVDAGDDEAVRAALLRAMSVHISTRERLPHLDEFYRELFRHLPRPNTLRDLACGLNPLAAPWMGLPAETVYIASDIDARLVGFVDEALTRLNVPHRTNVADLLEDRLDEPADVTLLLKTLPCLETQQRGSGWEVIDIVNSPNIVVTFPTKSLGQRSKGMFQNYSQSFESQARERSCRIQRLEIGNELIYVIQK
What is the function of this protein?
Specifically methylates the N(7) position of guanine 1405 in 16S rRNA.  Confers resistance to various aminoglycosides, including gentamicin, kanamycin and sisomicin.
What are the official names of this protein?
16S rRNA (guanine(1405)-N(7))-methyltransferase, 16S rRNA m7G1405 methyltransferase, Sisomicin-gentamicin resistance methylase Sgm.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Aminoglycoside resistance family.
Protein: RL6_MAGSA
Sequence: MSRVGKYPVSVPSGVTVQITGPEVTVKGKLGESKLTLRDNVEVTLDGNLIWVKPKNETKHARMMWGTTRAHLNNMVKGVSDGFTVNLEINGVGYRAAVEGKSLKLQLGYSHDIEYPIPDDVTMKCEKPTAISISGRDKRQVGQIAAEIRAFRGPEPYKGKGIKYETETILRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SPLA_STAAS
Sequence: MNENVMVKGLTALTILTSLGFAENISNQPHSIAKAEKNVKEITDATKEPYNSVVAFVGGTGVVVGKNTIVTNKHIAKSNDIFKNRVSAHHSSKGKGGGNYDVKDIVEYPGKEDLAIVHVHETSTEGLNFNKNVSYTKFADGAKVKDRISVIGYPKGAQTKYKMFESTGTINHISGTFMEFDAYAQPGNSGSPVLNSKHELIGILYAGSGKDESEKNFGVYFTPQLKEFIQNNIEK
What are the official names of this protein?
Serine protease SplA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1B family.
What are the subcellular locations of this protein?
Secreted.
Protein: OPPF_STRPQ
Sequence: MSEKLVEVKDLEISFGEGKKKFVAVKNANFFIKKGETFSLVGESGSGKTTIGRAIIGLNDTSSGQILYDGKVINGRKSKSEANELIRKIQMIFQDPAASLNERATVDYIISEGLYNFNLFKTEEERKEKIKNMMAEVGLLSEHLTRYPHEFSGGQRQRIGIARALVMNPEFVIADEPISALDVSVRAQVLNLLKRMQAEKGLTYLFIAHDLSVVRFISDRIAVIHKGVIVEVAETEELFNNPIHPYTQSLLSAVPIPDPILERQKELVVYHPDQHDYTLDKPSMVEIKPNHFVWANQAEIEKYQKEL
What is the function of this protein?
Part of the binding-protein-dependent transport system for oligopeptides.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Oligopeptide transport ATP-binding protein OppF.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DOXA2_MOUSE
Sequence: MTAWDGVLPFYPQPRHAASFSVPLLIVILVFLSLAASFLFILPGIRGHSRWFWLVRVLLSLFIGAEIVAVHFSGDWFVGRVWTNTSYKAFSPSRVQVHVGLHVGLAGVNITLRGTPRQQLNETIDYNERFTWRLNEDYTKEYVHALEKGLPDPVLYLAEKFTPSSPCGLYHQYHLAGHYAAATLWVAFCFWIIANALLSMPAPLYGGLALLTTGAFTLFGVFAFASISSVPLCHFRLGSAVLTPYYGASFWLTLATGILSLLLGGAVVILHYTRPSALRSFLDLSVKDCSNQAKGNSPLTLNNPQHEQLKSPDLNITTLL
What is the function of this protein?
Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2.  May play a role in thyroid hormone synthesis (By similarity).
What are the official names of this protein?
Dual oxidase maturation factor 2.
What is the protein family that this protein belongs to?
Belongs to the DUOXA family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GNAT3_MOUSE
Sequence: MGSGISSESKESARRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSKQECMEFKAVIYSNTLQSILAIVKAMATLGIDYVNPRSREDQEQLHSMANTLEDGDMTPQLAEIIKRLWGDPGIQACFERASEYQLNDSAAYYLNDLDRLTAPGYVPNEQDVLHSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFATTSIVLFLNKKDLFQEKVAKVHLSICFPEYTGPNTFEDAGNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction.  Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter.  Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody.  Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium.  GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors.  Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP.  Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
What are the official names of this protein?
Guanine nucleotide-binding protein G(t) subunit alpha-3, Gustducin alpha-3 chain.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBPB_HAEI8
Sequence: MKSVPLITGGLSFLLSACSGGGGSFDVDDVSNPSSSKPRYQDDTSSSRTKSNLEKLSIPSLGGGMKLVAQNLSGNKEPSFLNENGYISYFSSPSTIEDDVKNVKTENKIHTNPIGLEPNRALQDPNLQKYVYSGLYYIENWKDFSKLATEKKAYSGHYGYAFYYGNKTATDLPVSGVATYKGTWDFITATKYGQNYSLFSNARGQAYFRRSATRGDIDLENNSKNGDIGLISEFSADFGTKKLTGQLSYTKRKTDIQQYEKEKLYDIDAHIYSNRFRGKVTPTKSTSDEHPFTSEGTLEGGFYGPNAEELGGKFLARDKRVFGVFSAKETPETEKEKLSKETLIDGKLITFSTKTADATTSTTASTTADVKTDEKNFTTKDISSFGEADYLLIDNYPVPLFPEGDTDDFVTSKHHDIGNKTYKVEACCKNLSYVKFGMYYEDKEKKNTNQTGQYHQFLLGLRTPSSQIPVTGNVKYLGSWFGYIGDDKTSYSTTGNKQQDKNAPAEFDVNFDNKTLTGKLKRADSQNTVFNIEATFKNGSNAFEGKATANVVIDPKNTQATSKVNFTTTVNGAFYGPHATELGGYFTYNGNNPTATNSESSSTVPSPPNSPNARAAVVFGAKRQVEKTNK
What is the function of this protein?
Haemophilus acquires iron by extracting it from serum transferrin (TF) in its human host.  Acts as a transferrin receptor and is required for transferrin utilization.
What are the official names of this protein?
Transferrin-binding protein B, TbpB, Transferrin-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the TbpB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Cell surface. Note=When expressed in E.coli.
Protein: XPT_STAA3
Sequence: MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURR_ECOBR
Sequence: MLYLTKISNAGSEFTENEQKIADFLRARVSELKSVSSRQMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIDVISKAQFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIQRSSELTQRLK
What is the function of this protein?
Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc).  Binds to two adjacent inverted repeats within the operator region.  MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
What are the official names of this protein?
HTH-type transcriptional regulator MurR, MurPQ operon repressor.
Protein: SMC6_TAKRU
Sequence: MSKRKSISTHDKSTKRARPVEEEEDSEDADDRDQDVERLSPQVLPSGDVSDVGIVKSITLNNFMCHANLGPFAFGSNVNFIVGKNGSGKSAILTGLIVALGGNAQATNRGSSLKGFVKEGESFAVVSITLNNIGKDAYKPEVYGQAIVIDQKITREGIRTYKLKSQSGHIISTKKEDLVTILDYYNIQVNNPVTILTQEMSKYFLHSKGGAEKYKFFMKATQLEQMKDDFVHIKSTKSVTVDKVEQHSECLKDLKRDYLEKEDRYKSLASVNEMYTKLEELKKQMAWALVGEVEKEFEPMKEKLESDRCATNKFNEKVDEWKKKVEVAEGKQKQSHEQLEEITQQVSELQSKCTEFKTEVQRRNADLKSCEVTVHRHKAILRDLEKDKAQLSSKINDLSLSISQATGAESQARMERIAQIEAALEDLTHHTSTLGQQIEQYQHSYRHAIEGQGKMKRELEGLQKSIDANRRQLQSMESSRSNRLQRFGDQMPALLAAIDEAHKKGQFKHRPRGPLGYLISLKDPELALSIEICLKNLVQAFTCDNYDDERVLKSLMTKVLQHGRRPAIITSRFFPKVHDVSVRAVNHPDYPSVLQALEIEDPVVANCLIDQRAIECILLIKNRTEARRVMQGRNPPQNCTSAFSVEGDQIFTNRSYTADQTRANFLSKDVEEGIRHLKREMETQKVQAAHIQQQIRSTDKNISENQDLLRRTQTEQKTTEVKTMKLQLELTDLKNVEEPQSEDLAELKSAFENAEQEYKQHKQLIDTAAEEADVKKVETKLTPLFTSLSCNILWVHCLFVLLQEELSKTDQEVMKCKHHEKHYEERRNAHLCSIKTLENNVASKEKELQESIAKAKEICPEQLVVRRTARSLDVEITRLKVKIATQREHQGDREEIVREYHEALESYANKAQQIKNLNNFIKCLDRVMDQRLYAYTVLRRFLSARCKYYFDSMLAQRGFTGNMTFDHKNETLSISVQPGQGNKADLNDMRCLSGGERSFSTVCFVLSLWPITEAPFRCLDEFDVYMDMANRRNTQRQSGLKMATSQKIRQLIFLTPQSMSSLPECRRIHIVQLNDPVHGQTQMEQEEEGP
What is the function of this protein?
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination.  The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.  The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).
What are the official names of this protein?
Structural maintenance of chromosomes protein 6, SMC protein 6, SMC-6.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC6 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin.
Protein: SPO7_SCHPO
Sequence: MSSYVPNTLSVYHNLLILEASFRKTYLQLQVRRQKYMAFYVSLLVWNFYFGYRVFYRISKYSLIDLTYKLCLLCGIVTLLLFYFSGLYRTTIVYPSRYVQQVNKAMRFFNIRLVITPVPWFQVRKPLDCGVHLILSSKRFDILVIEGWEAFRSSYFASIHRKNNSIQSNESSESPSSKQN
What is the function of this protein?
Probable regulatory component of the nem1-spo7 complex which acts as a phosphatase and may be required for proper nuclear membrane morphology.
What are the official names of this protein?
Sporulation-specific protein spo7.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi- pass membrane protein.
Protein: HISX_HELMO
Sequence: MVRLITYPSIDADNYLQKKTLDDANVSVQVAQVLETIRCRGVEAVFEYTKRFDGATVNEANFRVSEAEIDEAYSKVDPEVLAALRRARDNIRRYHEKQLRPSWIEPEADGTMLGQLIRPLERVGTYVPGGLASYPSSVLMNAVPAKVAGVPQVVMATPPGKDGSINPYTLVAAREAGVDEIYRMGGAQAVAAMAYGAGLKAVDKITGPGNIYVTLAKKQVYGTVDIDMLAGPSEILVIADETAPPAYVAADFLSQVEHDVRAAAVLVTPSEILARAVEGEIQRQMDYLPRREIMEQALKDNSAVIVVKDLDEACEVANRYAPEHLEVLTKEPFALLGKLTQAGAIFLGPYSPEPVGDYYAGPNHVLPTGGTARFYSPLNVDTFMKKTSVIAYSKARFEQAADDILALAKCEGLDAHANAVAVRIEK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.