PharMolix/UniProtQA huggingface dataset:
Protein: SYC_NANEQ
Sequence: MLYLYNTLTSRKEAFIPLEEPFVKMYTCGVTPYDKAHVGHLRTYLVTDLLRRILRFLGYYDIAVTNFTDIDDKIIKKSQELNKDWKEIVEENIKYVFDVLKELKVLPFYVYPRVTYHIDDIANAVKSLLDRGYAYKGKYSIYFDVDKYPYYGQLSGIKSKKEWEQEKHLLEDKKNPYDFALWKFKQPGEPYWNTIVGEGRPGWHIECSVMSSKYLGERFDIHLGGSDLIFPHHENEIAQSETLYNVHPWVRYWVHIGMVQINGEKMSKSLGNIIEAKEFIKKYKPEFVRFFLLSTHYRKPLDISEENIEQAQTIYKKLTDAYNTAKSIVENEVSYRFDKDVRIILDYYREMIKAFLDDMNTPTAIASLNKIVSIFNQNPEYPIAYLTLRAFEDFNRIMNVWFEKPIDLDIINEIIEIRNMLRREKQYELADKIRDILQKKGIKIKDYKDKTVWYADI
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISY_SACS2
Sequence: MSVVSKGLENVIIKVTNLTFIDGEKGILRYRGYNIEDLVNYGSYEETIYLMLYGKLPTKKELNDLKAKLNEEYEVPQEVLDTIYLMPKEADAIGLLEVGTAALASIDKNFKWKENDKEKAISIIAKMATLVANVYRRKEGNKPRIPEPSDSFAKSFLLASFAREPTTDEINAMDKALILYTDHEVPASTTAALVAASTLSDMYSSLTAALAALKGPLHGGAAEEAFKQFIEIGDPNRVQNWFNDKVVNQKNRLMGFGHRVYKTYDPRAKIFKKLALTLIERNADARRYFEIAQKLEELGIKQFSSKGIYPNTDFYSGIVFYALGFPVYMFTALFALSRTLGWLAHIIEYVEEQHRLIRPRALYVGPEYQEYVSIDKR
What are the official names of this protein?
Citrate synthase.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
Protein: COBQ_ALIF1
Sequence: MRKYSPLMVQGTTSDAGKTVLVAGLCRLLANKGIQVAPFKPQNMALNSAVTEDGGEIGRAQALQADAARVKPHVHMNPILLKPNTDIGAQVIVQGKAIETMDAWGFHDYKKLAMPYVLESFSYLSNNYECVVIEGAGSPAEINLRENDIANMGFAEAADVPVIIVADIDRGGVFAHLYGTLALLSESEQARVKGFVINRFRGDISLLVPGLEWLEEKTGKPVLGVIPYLHGLNLEAEDAIKSEQLDKGKFIVKVPVVTRISNHTDFDPLRLHPEIDLQFIGKGDSLSGADFIILPGSKSVQADLEYIKSQGWDKDIERHLRYGGKVMGICGGYQMLGEHLADPLGIEGVPCRVKGLGYLSISTELQKQKQLTLVEGTLALPNQNAVKVKGYEIHAGVSTNLGKEHIPISIHTKDAMRYDGTINDENSIFGTYLHGVFDEPEAFEAILTWAGLEKCQAINMHDIQEEAIERIAKSMEDSLDLSLIWPDVFEKNKAY
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: RL21_LACPL
Sequence: MYAIIVTGGKQYKVEAGQAIYVEKLDAAAGDKVTFDQVVFVGGDTTKVGTPTVDGATVEGTVEKQGRDRKVVTFKYKAKKGQHTKKGHRQPYTKVTIDTINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: CYC_USTSP
Sequence: GFEDGDAKKGARIFKTRCAQCHTLGAGEPNKVGPNLHGLFGRKSGTVEGFSYTDANKKAGQVWEEETFLEYLENPKKYIPGTKMAFGGLKKEKDRNDLVTYLREETK
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: LAM1_YEAST
Sequence: MHEHKAELRLITVALNEASTDSPSFRASVNYFHTRMESLSSWMHSTVDYVENTYKPSFQDFQRIKETLFSQLLPSPILLSNGFVSNQPYTPLLVRDFTRDVSDLSNTVMKIILGDENSQYTAALSALSSDAINPYFNKRKTFEYYQRKYDSFLTDFLAATNDGNTLIPQNLQNETFKLVDIKHKYIEASLDLTEAISLMKVNLDKFLIETIDIVRKNNVITTKDTKDVIDITPELTETLKDWTDWIESNLQTLQALSSKLSEAKYAILKLSLARMKPSRLIQDYDLKSIQNLKFNLPKSISNGNNSEEKGLSGWLYMKTTVGHDPKRVVWVRRWCFLQNNVFGVFSLSPSKTYVEETDKFGILWITVEYLPKEPRNFCFKLRIQNPNCKTEEENTYIDIILQAESIDELKSWINTLTSHKRIALSIKEENDPRYQLARKKIEPQFFEFASSSSTSTDKLLTSFSSKTLTLVEELKKNYMSEDDIYSIIDNKAYHLRVISTPIATQLTHLALFSTFLSVSNYYPCATQANTWGTANWNDLSYLVNPLKGSSVHKPATVSNSSRFSVSYPDYYPYSLKVDDIQFRSIFFSVNHDFLQVPKELVLLRYSSVWCPNNKQKFASMAFVTLNHIYVYLNISGFSYLRRIDLLDIDSIEYDKSPKHVSSRMLHMQRGDGLRFNMSVFFTDRRAVASKLQFLIENKAMHIPKGEKEVLEIFQELDEEIENEKKIIKDNLSESEHYSKDYDYLLKSTYDHHFENTNETPMELMSRKLRLEREAWCYFQDNFKVGSKTLFHVLFGDKSQVFPSSLFLCKKGSNLNNNSYWERIRRAKEDASCQFELCRKLQFQLNRTSNFIKDLLWLKDDNDNFKLVLQQRVTKIKQGYYFEVEEGPIIVKFPLCHPLLLRVRFIIAECITSQGESLKKCDLAILYDFNYVESIDKLNTKVEKLWLFERIHLNWALRYCKLEHSEINRKTREYLKKFNDREKMSDVIKLCGFLGVLPKERIENDEKAGDFMQPVYINYDFLSLSKIFTKLTVFYLSSVIIKTMKVLLAMVMVIFKCFSKVNKTLYYCLLISAVTNLFFVGKSIHSYFSVKSAETLFQNYANGDQRGLQIMHRSLTVPDLNLLTRKMMDNDQENPVFKRFDEDKNAYQYKGTRQEIAIKRNQVLTELKILQNTEKELVQGSYRKFIITERDKCITTQNEIFDLWINDTKLQDYCMACFAEYNRLSAIPV
What is the function of this protein?
Involved in mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone (PubMed:15657396, PubMed:18800175).  May be involved in sterol transfer between intracellular membranes (PubMed:26001273).
What are the official names of this protein?
Membrane-anchored lipid-binding protein LAM1, Lipid transfer protein anchored at membrane contact sites 1, Yeast suicide protein 1.
What is the protein family that this protein belongs to?
Belongs to the SIP3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes to puncta in the cell periphery representing cortical endoplasmic reticulum (cER)-plasma membrane (PM) membrane contact sites.
Protein: RECX_CORDI
Sequence: MQSEKIAQLKAALQNFSASNSDLFDYALEEEKAKVRKRALLLLDQRARSVYELTNRLISADFDPNIVEYVVEDLVRANLLNDENFSREWVRQRRQRRGKSRQALTRELRDKGIKSEIIADVVGDIQPEDEQDIARELAYKKVRSLKKEPCDYPEYQKVLRRTVGVLARRGFSQSMALEIAREAIDARIDEIRR
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCA_BURMS
Sequence: MKIYAVGGAIRDALLGLPVRDRDYVVVGATPEQMAAQRFRPVGKDFPVFLHPDTHEEYALARTERKTAAGYHGFQFYYAPDVTLEQDLVRRDLTINAMAREVSPDGALVGPVVDPFGGQADLRAKLFRHVGDAFVEDPVRILRVARFAARFAEFAVAPDTAALMRAMVDAGEVDALVPERVWQELARGLMEAKPSRMFAVLRECGALARILPEIDALFGVPQRADYHPEVDTGVHVMMVIDHAAKQGYSLPVRFAALTHDLGKATTPADVLPRHIGHEGRSVDLLKPLCERLRVPNECRDLALVVAREHGNLHRVMEMGAAALVRLLERADALRKPARFAEALQASEADARGRLGLETKPYPQAERLRQALVAARAVDAGAIAQGLAGEPAKIKDAVHRARVRAVAQAVGVAD
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: Y727_SHEON
Sequence: MPRPKKCRQLSSCVPCSLFKPNGIPAANLSQILLAADEFEALELGDVQRLSQLEAAAQMGISRQTFGYLLASARQKVATAITQGLVLKLPTPNDKDPI
What are the official names of this protein?
UPF0251 protein SO_0727.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: G6PD_ZYMMO
Sequence: MTNTVSTMILFGSTGDLSQRMLLPSLYGLDADGLLADDLRIVCTSRSEYDTDGFRDFAEKALDRFVASDRLNDDAKAKFLNKLFYATVDITDPTQFGKLADLCGPVEKGIAIYLSTAPSLFEGAIAGLKQAGLAGPTSRLALEKPLGQDLASSDHINDAVLKVFSEKQVYRIDHYLGKETVQNLLTLRFGNALFEPLWNSKGIDHVQISVAETVGLEGRIGYFDGSGSLRDMVQSHILQLVALVAMEPPAHMEANAVRDEKVKVFRALRPINNDTVFTHTVTGQYGAGVSGGKEVAGYIDELGQPSDTETFVAIKAHVDNWRWQGVPFYIRTGKRLPARRSEIVVQFKPVPHSIFSSSGGILQPNKLRIVLQPDETIQISMMVKEPGLDRNGAHMREVWLDLSLTDVFKDRKRRIAYERLMLDLIEGDATLFVRRDEVEAQWVWIDGIREGWKANSMKPKTYVSGTWGPSTAIALAERDGVTWYD
What is the function of this protein?
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: URE1_HALH5
Sequence: MKLTRAQHASLYGPTVGDKVRLADTDLLLEIEKDYTVYGDECKFGGGKVLRDGMGQSAVYTRDEGVLDLIITNATIIDYTGIVKADIGIKDGHIVGIGKGGNPDIMDGVESHMIVGASTEAIAGEGLIVTAGGIDAHIHFISPQQIDVAIASGITTMLGGGTGPATGTKATTCTPGKWNIERMLEAADAFPVNLGFLGKGNASTPAPLREQIEAGAIGLKLHEDWGTTPAAIRTCLSVADRMDVQVAIHTDTLNEAGFVEDTIKAIGDRVIHTYHTEGAGGGHAPDIMKVAGLPNVLPSSTNPTRPFTVNTIDEHLDMLMVCHHLDPNVPEDVAFADSRIRPETIAAEDILQDLGVISMISSDSQAMGRVGEVIIRTWQTADKMKKQRGALAEDQGKGNDNVRIKRYVSKYTINPAITHGIDDYVGSVEVGKLADLVLWDPRFFGVKPELILKGGLIAYSQMGDPNASIPTPQPVFSRPMFGSFGRARGTTSITFLSKAAMDLGVHEALGLQKKIAHVKNCRSISKRSMKYNDATPNIEIDPETYEVKVDGEMITCKPFEEVALAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
Protein: CC85C_HUMAN
Sequence: MAKPAATAAAASEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQDDNQELRELCCFLDDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLLLDEERAALAATGAASGGGGGGGGAGSRSSIDSQASLSGPLSGGAPGAGARDVGDGSSTSSAGSGGSPDHHHHVPPPLLPPGPHKAPDGKAGATRRSLDDLSAPPHHRSIPNGLHDPSSTYIRQLESKVRLLEGDKLLAQQAGSGEFRTLRKGFSPYHSESQLASLPPSYQDSLQNGPACPAPELPSPPSAGYSPAGQKPEAVVHAMKVLEVHENLDRQLQDSCEEDLSEKEKAIVREMCNVVWRKLGDAASSKPSIRQHLSGNQFKGPL
What is the function of this protein?
May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable).  May play an important role in cortical development, especially in the maintenance of radial glia (By similarity).
What are the official names of this protein?
Coiled-coil domain-containing protein 85C.
What is the protein family that this protein belongs to?
Belongs to the CCDC85 family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell junction, adherens junction. Note=Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall.
Protein: COAD_PYRAB
Sequence: MMKFKKVVVGGTFDRLHLGHKALLRKAFEVGKIVYIGLTSDDMVKNKPYAEKILPYERRLKDLIEFLEVNNFRRYRIIKINNAIGFTTRIRSLEAIVVSEETYKGALLVNRAREEVGLRPLEIIVIPIIKSKLGDKISSSLIRAGLIDPFGNPIKRE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNFA_PAPHU
Sequence: MSTESMIRDVELAEEALPRKTAGPQGSRRCWFLSLFSFLLVAGATTLFCLLHFGVIGPQREEFPKDPSLISPLAQAVRSSSRTPSDKPVVHVVANPQAEGQLQWLNRRANALLANGVELTDNQLVVPSEGLYLIYSQVLFKGQGCPSNHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINLPDYLDFAESGQVYFGIIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.
Protein: PFKA_VIBC1
Sequence: MIKKIGVLTSGGDAPGMNAAVRGVVRTALSEGLEVYGVYDGYLGLYEGRIEKLDRSSVSDVINKGGTFLGSARFPEFKEVEVREQAIENLKKHGIDALVVIGGDGSYMGAKKLTEMGYPCIGLPGTIDNDIAGTDYTIGYLTALNTVIDAIDRLRDTSSSHQRISIVEIMGRHCGDLTLMSAIAGGCEYIITPETGLDKDKLIKNIQDGIAKGKKHAIIALTELMMDANELAREIEAATGRETRATVLGHIQRGGRPAAFDRVLASRMGNYAVHLLMEGHGGRCVGIVKEQLVHHDIIDAIENMKRPVRSDLYQVAEELF
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRN2_YEAST
Sequence: MKVKATKLRIKQRRKNKGLNISRLDIIRAEMDVVPSPGLPEKVNEKSKNIPLPEGINLLSSKEIIDLIQTHRHQLELYVTKFNPLTDFAGKIHAFRDQFKQLEENFEDLHEQKDKVQALLENCRILESKYVASWQDYHSEFSKKYGDIALKKKLEQNTKKLDEESSQLETTTRSIDSADDLDQFIKNYLDIRTQYHLRREKLATWDKQGNLKY
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.  Required for normal endocytic and biosynthetic traffic to the yeast vacuole.
What are the official names of this protein?
Protein SRN2, ESCRT-I complex subunit VPS37, Vacuolar protein sorting-associated protein 37.
What is the protein family that this protein belongs to?
Belongs to the VPS37 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome. Late endosome membrane; Peripheral membrane protein.
Protein: FGNB_ASPFU
Sequence: MTVNGKDIDSPNAQYVAAGIDMSDLFPAPFPTNVKTVHLETLSLAKLLQRDEDELRRIYENCKDPGFFQLDLTDDEQGVQLLQDAVDCARLMKQLLPNMSVEEKRMYKQHSRVGVYSKGYQVYDVLPNGQPKYNETVNFPMTEMLGYGDSTVDLPDWLSPHRELFQRTMRSGNKIANIVLAALEVGLQVPRGALTDAHRIQDPSDDFLRLLRYPGLQPGQPRDDLCFPAHKDFTSLGILFTWLGGLQLLASASAPGVTSGTMTGPLDIAEDAWRWVQPVPGTAIVNVGNALEILTNKALTSGLHRVVRAPGEQLPFDRYSVLVGTRPANSFPMKPLQSPQISPVLDPAAAEIATMTSGQWGTHNIGSFNNWVKARTERQEVLIIP
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of fumigermin that inhibits germination of spores of the inducing S. rapamycinicus, and thus helps the fungus to defend resources in the shared habitat against a bacterial competitor (PubMed:32083553).  The partially reducing polyketide synthase fngA alone is sufficient for the production of fumigermin (PubMed:32083553).  FgnA catalyzes the condensation of 3 malonyl-CoA units to an acetyl-CoA starter, and 3 methylations to yield fumigermin (PubMed:32083553).  It is remarkable that the five cluster genes including fgnA are conserved in distantly related fungi, supporting the assumption of a fumigermin cluster; it is thus possible that originally all five genes were functional, but that the genes encoding tailoring enzymes became inactive from mutations, similar to the case of the fgnA gene in strains A1163 and Af293 (Probable).
What are the official names of this protein?
2-oxoglutarate-dependent dioxygenase AFUA_1G01000, Fumigermin biosynthesis cluster protein AFUA_1G01000.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: HISX_XANC8
Sequence: MNTLDWTQLTADARTQALTRPVQTVATQTREAVATLIADVRARGDVALREITARFDGVTLDSFAVSEAEFAAADAAIAPELRQAMQDAVARIDTFHRAGMSEGYAVETAPGVVCEKIVRPIGRVGLYVPAGSAPLPSTALMLGVPARLAGCREVVLCTPPRKDGSVDPAVLVAAQLTGVRRVFKLGGAQAIAAMAYGTDSIPSCDKLFGPGNSFVTEAKQQVAQSGAAAIDMPAGPSEVLVIADAGAQPAFVAADLLSQAEHGPDSQVLLLSDSDALIAAVQEQLDLQLAQLSRADIARQALAQSRLIKVATLQEAFEISNRYAPEHLILALREPRAWLAQVEAAGSVFLGDYTPEALGDYCSGTNHVLPTSGAARAYSGVSVASFQNMVSVQAASKAGIDGIGACALILARAEGLDAHANAVALRMGVAA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: FEN1_ASPCL
Sequence: MGIKHLFQVIQENAPDAVKSGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKAEATEAHEEAKETGTAEEIEKFSRRTVRVTREHNAECKKLLKLMGVPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNRVLEGLDMDRSQFIDMCILLGCDYLEPIPKVGPNTALKLIREHGSLEKVVEAIESDPKKKYVIPEDWPYQDARELFHHPDVRAADHPECDFKWEAPDIEALVDFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVAKTDAEKASLKRKHDEKLQEQKKRKKEEAKAKKEAKAKPRGAA
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: NUDL_KLEP3
Sequence: MADHALNLDDFLSRFQLLRPQPSRHALNQRQAAVLVPIVRRPQPGLLLTQRSPLLRKHAGQVAFPGGAVDNTDATLIAAALREAQEEVAIPPEAVEVIGVLPPVDSVTGFQVTPVVGIIPPNLHYHASQDEVSAVFEMPLAEALRLGRYHPLDIHRRGNDHRVWLSWYQHYFVWGMTAGIIRELALQIGARP
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: RL6_BIFAA
Sequence: MASHIGKLPVTIPAGVEVKIDGQSFTAKGAKGTDSYEIPEGITAVVEGNEVVLTPADDLRPTRAKHGLARSIVAGMVKGVHEGYAKTLEIVGTGYRAQMKGKGIEFSLGYSHTITVEPPAGIEFELPNPNQVIVKGIDKQAVGQCAANIRKLRAPEPYKGKGIKYADEHILRKAGKAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PDXB_CITK8
Sequence: MKILVDENMPYARELFSRLGEVKAVPGRPIPVAELDDADALMVRSVTKVNEALLGGKSIKFVGTATAGTDHVDEAWLKQAGVGFSAAPGCNAIAVVEYVFSALLMLAERDGFALSDRTVGIVGVGNVGARLQARLEALGIRTLLCDPPRADRGDEGDFRSLDELVQEADILTFHTPLYKEGPYKTLHLADEALIGRLKPGTILINACRGPVVDNTALLARLNAGQSLSVVLDVWEGEPDLNVALLEKIDIGTSHIAGYTLEGKARGTTQVFEAYSTFIGRAQKVALDTLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDASAATLLHKLGFNAVHHPAH
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_NEOSM
Sequence: MGNGFSDVNALSNVSSDGYLVAKLDDLINWARSGSLWPMTFGLACCAVEMMHFTASRYDMDRFGMIFRPSPRQSDVMIVAGTLTNKMAPALRRVYDQMAEPKYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALLYGVLCLQKKINRQRNFIRR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MRAZ_BURA4
Sequence: MFQGASALTLDAKGRMSVPSRYREALQGQAEGRVTVTKHPDGCLLLFPRPEWEVFRAKIAALPMDAHWWRRIFLGNAMDVDLDSAGRILVSPELRMAAGLEKEVMLLGMGSHFELWDSQTYIAKEQAAMAQGMPDALKNFTF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RS16_BACFN
Sequence: MATRIRLQRHGRKSYAFYSIVIADSRAPRDGKFTEKIGTYNPNTNPATVDLNFERALHWVLVGAQPSDTVRNILSREGVYMKKHLLGGVAKGAFGEAEAEAKFEAWKNNKQSGLSALKAKEEEAKKAEAKARLEAEKKVNEVKAKALAEKKAAEEAAKAAAEAPAEEAAPAEEAATEAAAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: Y522_CHLAA
Sequence: MNQRQLMQMAQQMQRQMQKVQEELAATIVEGTAGGGAITVKMNGHREVQSITISPEVVDPDDVEMLQDLLLVAINDASRKAQQLAEERMQPLTGGLKGLF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Caur_0522.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CYNS_AJECH
Sequence: MSNINLATLDISEHPNLPTSSAVLFKAKDDKKLSFEKIASHVGRNEVATAAIFYGQAKASAEDIVRLAEVLGIDHGQLAFLLGGFPDRGKSVPFPPKDPLIYRLYEIVQNYGYAYKAVMNEKFGDGIMSAISFSTKVEKETDKDGNDWAVVTWRGKWLPYSRF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.