PharMolix/UniProtQA huggingface dataset:
Protein: CCL5_SIGHI
Sequence: MKISAAVLTVVLMAASLCAPASASPNGSDTIPCCFAYLSAVLPRAHVKEYFYTSSKCSNFAVVFVTRRNRQVCANPKKKWVQEYINYLELK
What is the function of this protein?
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils.  Causes the release of histamine from basophils and activates eosinophils.  May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5.  May also be an agonist of the G protein-coupled receptor GPR75.  Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases.  By activating GPR75 may also play a role in insulin secretion by islet cells.
What are the official names of this protein?
C-C motif chemokine 5, Small-inducible cytokine A5, T-cell-specific protein RANTES.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GYRA_MYCBP
Sequence: MTDTTLPPDDSLDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSADDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.  Relaxes negatively supercoiled DNA in an ATP-independent manner.  A linear reaction intermediate can be trapped in the presence of the antibiotic ciprofloxacin (PubMed:7503546).  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMD6_XENLA
Sequence: MFERELEALGFEKTGDLIKIVPPDLFAELCQQSVQHLQRQRSGVDCHAIFQSFQAVGVHISEDELRKIIRGMTALFSTAAKYNVTCEELLSMLISKLPKQILQVIRHVWNEEGKHLCELQKSRDLLPSGELVDFHWKIGMAVSSDSCRSLNHPYVTVELKVADYSGQITSKILELTIPEFKNFHKQFKEMSAVLETV
What is the function of this protein?
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes.  Inhibits TNF-induced nfkb1 activation.
What are the official names of this protein?
COMM domain-containing protein 6.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GRAK_RAT
Sequence: MSFSSSALVFLVAGIYMSSESFHTEIIGGREVQPHSRPFMASIQYRGKHICGGVLIHPQWVLTAAHCYSRGHSPTVVLGAHSLSKNEPMKQTFEIKEFIPFSGFKSGTNDIMLIKLRTAAELNKHVQLLHLRSKNYIRDGTKCQVTGWGSTKPDVLTTSDTLQEVTVTIISRKRCNSQSYYNHKPVITKDMICAGDRRGEKDSCKGDSGGPLICKGVFHALVSGGYKCGISNKPGVYTLLTKKYQTWIKSKLAPSSAH
What are the official names of this protein?
Granzyme K, NK-tryptase-2, NK-Tryp-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
What are the subcellular locations of this protein?
Cytoplasmic granule.
Protein: YQGF_THET2
Sequence: MRVGALDVGEARIGLAVGEEGVPLASGRGYLVRKTLEEDVEALLDFVRREGLGKLVVGLPLRTDLKESAQAGKVLPLVEALRARGVEVELWDERFTTKLAQERLKHAPKRLRRDKGKLDELAAVVLLEDYLARGI
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZCHC2_RAT
Sequence: MLRMKLPPKSTHPSEPPPDAEEPEADARPGAKAPPRRRRDCRPPPPPPTGLPRGPPPPPPSPPRGLEPPVASGPTAGAGMPGGGGHAAALREQERVYEWFGLVLGSAQRLEFLCGLLDLCNPLELRFLGSCLEDLARKDYHYLRDSEAKANGLSDPGSLADFREPAVRSRLIVYLALLGSENREAAGRLHRLLPQVDAVLRSLRATRVEGSRGSVEDEPGGDDEQDAEKDGPGPEGGGCAKLGTGGGLGFRAQEELLLLFTMASLHPAFSFHQRVTLREHLERLRSALRVEPEDAEVEPSNFAGSRAQNDSACGDYIQSNETGLVEQAQIPQDGLTVAPHRAQREAVHIEKIMLKGVQRRRADKYWEYTFKVNWSDLSVTTVTKTHQELQEFLLKLPKEFSSESFDKTILKALNQGSLRREERRHPDLEPILRQLFSTSPQAFLQSHKVRSFFRSISSESQHSFNNLQSSLKTSKILEHLKEDSSEASSQEEDVLQHTIIHKKHAGKSPAGNVATSCALLEGLTMQYAEQNGVVDWRNQGCAAIQHSEHCVSSADQLSAEKRSLSSVNKKKGKPQVEKEKIKKTENRLSSRINGIRLSAPQHAHGSTVKDMNLDVGSGHDTCGETSSESYSSPSSPRHDGRESLESEEEKDRDTDSNSEDSGNPSSARFAGHGSVTQTVSVQPPADTVSLGTENGNLLEAPLTSHKYPHIPFMPTLPCVMHNGAQKSEVVIPSPKSADGKAVGVLVPNPVAISTMMESTNAAPVGILGPAASGESEKHLELLASPLPIPSPFLPHSSAPALQLTLQSLKLQPPQGASENCPVNIPQQAATRLSIGSPNTALIPVHNPGAFPGSPVAATDPITKSASQVVGLNQMVPQIEGNTGTVPQPNNVKVVLPAAGLSAAQPPASYTFPGSPLAASVLPTQNSTVLNTATSAQPASTGISPAQSTVPPAVPTHTPGPAPSPSPALTHSTAQSDSTSYISAVGNTNANSTIVPPQPLGPCGSCGRRCSCGTNGNLQLNSYYYPNPMPGPMYRLPSFFTLPSICNGSYLNQAHQSNGNQLPFFLPQTPYANGLVHDPVMGSQASYGMQQMAGFGRLYPVYPAPNVVANTSGSGPKKNGSVSCYNCGVSGHYAQDCKQSSMEANQQGTYRLRYAPPLPPSNDTLDSAD
What are the official names of this protein?
Zinc finger CCHC domain-containing protein 2.
Protein: RS10_BRAHW
Sequence: MKEQKIRVKLKAFDIELIDQSAQSIVASVKKTGARVSGPIPLPTSIRKVTVIRSPHVNIKSREQFEMRIYKRLIDIFDVTPQTTESLKKLALPAGVDVQLK
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RLUE_SALTI
Sequence: MRQLISSENTMQKTSFRNHYVKRFSSRQASKSRKENQPKRVVLFNKPYDVLPQFTDEAGRRTLKDFIPVQGVYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGIPDNAALQALRTGVTLNDGPTLPAGIEIVAEPDWLWPRTPPIRERKNIPTSWLKVTLYEGRNHQVRRMTAHVGHPTLRLIRYSMGDYTLNGLDNGQWCEIAQEKDR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase E, rRNA pseudouridylate synthase E, rRNA-uridine isomerase E.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: RM11_HUMAN
Sequence: MSKLGRAARGLRKPEVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEKGARQTGKEVAGLVTLKHVYEIARIKAQDEAFALQDVPLSSVVRSIIGSARSLGIRVVKDLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK
What are the official names of this protein?
39S ribosomal protein L11, mitochondrial, L11mt, MRP-L11, Mitochondrial large ribosomal subunit protein uL11m.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SLA_ECHML
Sequence: MGRFISVSFGLLVVFLSLSGTGADFDCPSDWTAYDQHCYLAIGEPQNWYEAERFCTEQAKDGHLVSIQSREEGNFVAQLVSGFMHRSEIYVWIGLRDRREEQQCNPEWNDGSKIIYVNWKEGESKMCQGLTKWTNFHDWNNINCEDLYPFVCKFSAV
What is the function of this protein?
EMS16 is a potent and selective inhibitor of alpha-2/beta-1 (ITGA2/ITGB1) integrin and acts as a potent antagonist of platelet aggregation and cell migration.  Binds specifically to the I domain of the alpha-2 subunit, in a metal ion-independent fashion.
What are the official names of this protein?
Snaclec EMS16 subunit alpha, EMS16A.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: GALT_LIGS1
Sequence: MDDKLLLDTFIKQVIEQENYTELDRNYLYNRILNLVGEGVEKLTTTKNEIIDLKNELVEYAVQHGKVGETLNEQDCLGAELMNFITPLPSKVNQDFWQTYQQKSPEEAIQNFYDLSKRNDYIKTKAIAKNIYFPVETSYGQLEITINLSKPEKDPKQIALAKKMKASGYPLCQLCMENEGYQGRINYPARANHRIIRFDLDDKQWGFQYSPYAYFNEHCIFLDTIHEPMEITKQTFNNLLGIIEQFPGYFVGSNADLPIVGGSILTHEHYQGGRHTFAMEKAPIETELKFAGYEDIQAGIVKWPMSVIRLRGNSKEDLVDLADKILKTWRGYSDEEVSVLAESNGEKHHTITPIARKRDGQLELDLVLRDNQTSEQYPDGIYHPHPDVQHIKKENIGLIEVMGLAILPPRLKGELQEVEKYLLGQENKMEEYHQVWADDIKQKYSDISQENVGTIIQQELGRVFARVLEDAGVYKHDETGRMAFKRFVEEVGIVD
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBT_BRUAB
Sequence: MSASGLPFDDFRELIRNLPGPDLGAERAVREREVTLTKPAGSLGRLEEIVAWLATWTGKRTPQVNRPLVAVFAGNHGVTAKNITPFPPSVTAQMVENFAAGGAAINQICIANDLGLKVFDLALEHPTGDITEEAAMDEHTCAATMAFGMEAIAGGTDLLCIGEMGIGNTTIAAAIALALFGGTAEDWVGPGTGSTGELMQRKLAAVRQAVALHQPHLQDPLEVLRCLGGREIAAMAGAILAARMEKIPVIVDGFVASAAAAVLYAANPEAIDHCMFGHVSAEPGHRKLLAKMGKEPLLDLGMRLGEGTGAALAANIVKAAALCHSGMATFEQAGVSASK
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: Y755_METJA
Sequence: MWKKLMLLLLMAIPLVSAVAIPSISATDVVLVSDNCADQCTALEVADALNATVITTEWGIYNESLIDEILALNPDKVIIIGGPLAVVENYTTALENVGITVERIGGSNRYETNANVTLRFQNQFRYAFGNNTTVCVCHGFDDIALNETMGLIKNGTCLVLLTNGVNLSVEPQKLQLRINKVEIIENPICPFCNYSKLMLKLQKNGLKIEIKQIPKVKVKLMLQNRIRIMERRILMLKRMGVNVTDLEEKLKEVEQLMEQNRYQEAYRIMVQLQEEQMVRVKLHLHPMWSKMKRGKIQENKNASHIYHQNINNLTNELNTSRGGIGGINAPHIYHQRINSTIQ
What are the official names of this protein?
Uncharacterized protein MJ0755.
Protein: RS4_CHLMU
Sequence: MARYCGPKNRIARRFGANIFGRGRNPLLRKPNPPGQHGMQRKKKSDYGLQLEEKQKLKACYGMILEKQLVKAYKEVVHKQGNVAQMFLEKFECRLDNIVYRLGFAKTIFAAQQLVSHGHVLVNGKKVDRRSFFVRPGMQISLKEKSRRLAIVTESLENKDQSSLPAYLSLDKAAFKGELVVSPELDQISSQLPLPVNVSVICEFLSHRT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: BBS5_HUMAN
Sequence: MSVLDALWEDRDVRFDLSAQQMKTRPGEVLIDCLDSIEDTKGNNGDRGRLLVTNLRILWHSLALSRVNVSVGYNCILNITTRTANSKLRGQTEALYILTKCNSTRFEFIFTNLVPGSPRLFTSVMAVHRAYETSKMYRDFKLRSALIQNKQLRLLPQEHVYDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNDSFNVSIPYLQIRSIKIRDSKFGLALVIESSQQSGGYVLGFKIDPVEKLQESVKEINSLHKVYSASPIFGVDYEMEEKPQPLEALTVEQIQDDVEIDSDGHTDAFVAYFADGNKQQDREPVFSEELGLAIEKLKDGFTLQGLWEVMS
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for BBSome complex ciliary localization but not for the proper complex assembly.
What are the official names of this protein?
Bardet-Biedl syndrome 5 protein.
What is the protein family that this protein belongs to?
Belongs to the BBS5 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to basal bodies.
Protein: IPYR_PSEGP
Sequence: MDLSRIPPQPKAGILNVLIEIPAGS
What is the function of this protein?
Hydrolyzes PPi generated in anabolic reactions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_CHLMU
Sequence: MIQQESQLKVADNTGAKKVKCFKVLGGSRRRYATVGDVIVCSVRDVEPDSSVKKGDVVKAVIVRTRNDIRRKDGSTLRFDTNSCVIIDDKGNPKGTRIFGPVAREIRDRGFIKISSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SYFA_CLOB8
Sequence: MKEKLKELQELALSKIEAVKTSSELEEIRVKFLGKKGELTTILRGMGNLSPEERPIVGKLVNEAKAAVEEKLESVLKAIKDKEKAEKLAGETIDISLPGRKKVIGKRHPLDLTLQSMEEIFVSMGFTIEDGPEVEYDHYNFEALNIPKDHPARSEQDTLYINDNIVLRTQTSPIQVRTMENQKPPIKMISPGKVYRSDSVDATHSPIFYQMEGLVIDKGVTFADLKGTLELFAKKMFGDKVQTKFRPHHFPFTEPSAEMDATCFVCGGEGCRVCKGSGWIELLGCGMVHPNVLRNCGLDPEVYSGFAFGFGVDRMVMLKYGIDDIRLLYESDMRFLNQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4KH_SINFN
Sequence: MRERAVGSKGSFPIGIAELQEVSCASVEINQPLLLADLRSDGMLRMRIPTDAARAASHELGKQWSRALWLHDEKPDGIIYDSRLNGEANTALFDRALPKLNVKSSGPLLDFRDEVAQILDDFSLEIV
What is the function of this protein?
Probable toxic component of a type II toxin-antitoxin (TA) system.  It is not known which gene encodes its antitoxin.
What are the official names of this protein?
Probable toxin y4kH.
What is the protein family that this protein belongs to?
Belongs to the MbcT/ParT/Res family.
Protein: DCYD2_ORYSJ
Sequence: MRPSPALAGGGRTVANLLSATEWMLPSPATQVHTISVLPSHSPPSPPHHFAFSNLTTAPKRNGGKGEEEGRPRFEVVRDDLLHPLANGNKARKLDALLPLLRRRGATDVVTCGGCQSAHAAATAVHCAEWGMRPHILLRGEQPDIPTGYNLISLMFGNVAYASRSVYAHRDEMLYNHARKVAGTGGTVLWADDISKEDFVLDEDNGCEIGSRRVVIIKEGAGDVQALLGVIRLVEYLYNLSSFHKHENVHVVVDAGTGTTAVGLALGAVCLGLHWRVTAVMLADTLERYKEREKSLISDFKKLCHNNYHEMVGENDIGDSLVEWVERFSPRRFGKVLNGEIALCRQIAQQTGILLDPMYTLAGWEQAVDLCVGDSRTKVVMIHTGGTLGFCGLAQRYSSHFTSDEQT
What is the function of this protein?
Catalyzes the production of hydrogen sulfide (H2S) from cysteine.
What are the official names of this protein?
Putative D-cysteine desulfhydrase 2, mitochondrial, OsD-CDes2, D-CDes2.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NREP_MACFA
Sequence: MVYYPERFVWVSQEPFPNKNMEGRLPKGRLPVPKEVNRKKNDETNAASLTPLGSSELRSPRISYLHFF
What is the function of this protein?
May have roles in neural function and cellular differentiation.  Ectopic expression promotes axonal regeneration, induces differentiation of fibroblast into myofibroblast, induces myofibroblast ameboid migration, augments motility of gliomas, and increases retinoic-acid regulation of lipid-droplet biogenesis.  Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3.  May play a role in the regulation of alveolar generation.
What are the official names of this protein?
Neuronal regeneration-related protein, Neuronal protein 3.1, Protein p311.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QTRT2_MOUSE
Sequence: MKLSLIKVVNGCRLGKIQNLGKAGDCTVDIPGCLLYTRTGSAPHLTHQTLRNIHGVPGIAQLTLSSLAEHHEVLAEYKKGVGSFIGMPESLFYCSLHDPVTPGPAGYVTSKSVSVWGFGGRVEMTVSKFMAIQEALQPDWFQCLSDGEASCAETTSIKRARKSVDRSLLFLDSCLRLQEESEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGDPAVTETRLHLLSSVTAELPEDKPRLICGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFTFDCQLNPEETLLQQNGIQEKIKGLDQAKKIEATGCNQEMTSFEINLKEKKYQEDFDPLVRGCSCYCCKNHTRAYIHHLLMTNELLAGVLLMMHNFEHYFGFFCSIREALKNDTLAQLKELICRQMF
What is the function of this protein?
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=May associate with the mitochondrion outer membrane.
Protein: ACHA3_BOVIN
Sequence: MARRSRLRRLLLLLLLPVASTSDAEHRLFERLFEDYNEIIRPVANVSDPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYDGAEFMRVPAEKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPAWVKTIFLNLLPRVMFMTRPASNEGNTQRPRPFYSAELSNLNCFSRIESKVCKEGYPCQDGLCGYCHHRRAKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMTRDDA
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: BOA2_BOTFB
Sequence: MSSEKMPIETLQADEHRFAIILGAGAAGIIQGCTFIREKTLPLEEFQILERQSAFGGVWWKNTYPGAACDIPSHEYQISFALNPYWSRTFAPQPEIQKYFEDVALQYELHKSTTFNTEIVEAKWDDSRLLWLVETTDLTTGDTKLWSCHVLIGALGAFTVPKKAPVKNVDAFKGEEWHSVDWPKNANLKGKTVAVIGTGPSACQFIPNIYPEVKSLIVYQRSPGHVLPRNDVVVGSLTKWMFAHIPFLMRFNRWFWMKKDEILRPRLFTVGSWLQKIVISMTRNHLYKQIKDDTLRRKLESKDVFGCKRPLMLSDYYPIFNNDNVELVTDSVTELTENGIKSRNTDTGEEMERETDVLIWGTGYNPVDFGLPVPTKGRSGQLLCDKYQPELFSLYGVAVDDFPNYFNFLGPNSSSFETSVMELFELQAHHNSIATEYLFQKNVGTFRYAIMPKEERVRSWTLSLRPGQAKLPPANPNCKSYYRSKIGHVYRYPYPYWQYKALIAKLDFKRDWVLLQQRIGQKEVKVLEF
What is the function of this protein?
FAD-binding monooxygenase; part of the gene cluster A that mediates the biosynthesis of botcinic acid and its botcinin derivatives, acetate-derived polyketides that contribute to virulence when combined with the sesquiterpene botrydial (PubMed:18208491, PubMed:21722295).  Botcinic acid and its derivatives have been shown to induce chlorosis and necrosis during host plant infection, but also have antifungal activities (PubMed:18208491, PubMed:21722295).  Two polyketide synthases, BOA6 and BOA9, are involved in the biosynthesis of botcinins.  BOA6 mediates the formation of the per-methylated tetraketide core by condensation of four units of malonyl-CoA with one unit of acetyl-CoA, which would be methylated in activated methylene groups to yield a bicyclic acid intermediate that could then either be converted to botrylactone derivatives or lose the starter acetate unit through a retro-Claisen type C-C bond cleavage to yield botcinin derivatives (PubMed:23203902).  The second polyketide synthase, BOA9, is probably required for the biosynthesis of the tetraketide side chain of botcinins (Probable).  The methyltransferase (MT) domain within BOA6 is probably responsible for the incorporation of four methyl groups (Probable).  The trans-enoyl reductase BOA5 might take over the enoyl reductase function of BOA6 that misses an ER domain (Probable).  The monooxygenases BOA2, BOA3 and BOA4 might be involved in further hydroxylations at C4, C5 and C8, whereas BOA7, close to BOA9, could potentially be involved in the hydroxylation at C4 in the side chain of botcinins (Probable).
What are the official names of this protein?
FAD-binding monooxygenase BOA2, Botcinic acid biosynthesis cluster A protein 2.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: APT_MALP2
Sequence: MGYEEIKNTIATIEDFPKKGISFKDITPLLLDHKKMNFIIDELAKFAKTIDFDIIVAPESRGFLFGLPLALNLKKPFVPIRKKGKLPREVISQEYELEYGKATIEVTKNDIPANSKVLIIDDLIATGGTTVAIQDLVTKLGSTVVGQAYLIELVGLCDYEKLQGKFFSMIKY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMK_SHIDS
Sequence: MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIHYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGDFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIAGKMIRWIERHATTEYCLKTGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: HCP15_BPSPP
Sequence: MDIQRVKRLLSITNDKHDEYLTEMVPLLVEFAKDECHNPFIDKDGNESIPSGVLIFVAKAAQFYMTNAGLTGRSMDTVSYNFATEIPSTILKKLNPYRKMAR
What is the function of this protein?
Head completion protein that exhibits an open central channel for viral DNA ejection.  Part of the head-tail connector by binding to the portal protein and to the head completion protein 16.
What are the official names of this protein?
Head completion protein gp15, HCP, Connector protein gp15, Gene product 15, Gp15.
What are the subcellular locations of this protein?
Virion. Note=Part of the connector between the portal and the tail.
Protein: RS11_PYRAR
Sequence: MSAEQQPQQQQKLRWGIAWIYSSSNNTIITITDLTGAETVARVSGGQVVRADKDKPSPWAAMQAAYKAAQLAMARGINAVHIKVRGPGGYGMKVPGPGASAAIRALARSGLVIGRIEDVTPIPHDIIRPPSGRKGRRV
What is the function of this protein?
Located on the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.