PharMolix/UniProtQA huggingface dataset:
Protein: DOK1_HUMAN
Sequence: MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST
What is the function of this protein?
DOK proteins are enzymatically inert adaptor or scaffolding proteins.  They provide a docking platform for the assembly of multimolecular signaling complexes.  DOK1 appears to be a negative regulator of the insulin signaling pathway.  Modulates integrin activation by competing with talin for the same binding site on ITGB3.
What are the official names of this protein?
Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62.
What is the protein family that this protein belongs to?
Belongs to the DOK family. Type A subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, perinuclear region.
Protein: SARNP_MOUSE
Sequence: MAAETVELHKLKLAELKQECLARGLETKGIKQDLINRLQAYLEDHAEEEANEEDVLGDETEEEEPKPIELPVKEEEPPEKAVDMASEKKVVKITSGIPQTERMQKRAERFNVPVSLESKKAARAARFGISSVPTKGLSSDTKPMVNLDKLKERAQRFGLNVSSISRKSEDDEKLKKRKERFGIVTSSAGTGTTEDTEAKKRKRAERFGIA
What is the function of this protein?
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form.  Specifically binds to scaffold/matrix attachment region DNA.  Also binds single-stranded RNA.  Enhances RNA unwinding activity of DDX39A.  May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis.  Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA.  TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
What are the official names of this protein?
SAP domain-containing ribonucleoprotein, Nuclear protein Hcc-1.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: ATPD_YERE8
Sequence: MSEFVTVARPYAKAAFDFAVEHQAVDRWQDMLAFTAQVTRNEQIAELLSGAVAPETMSKTFIAVCGDQLDEPAQNFIRVMAENGRLLVLPEVLLQFIQLRASLESTVDVEVSSASPLNDEQLAKIAAAMEKRLSRKVKLNCKIDKSVMAGVVIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TETR8_PHODP
Sequence: MARLNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARHHDYSLPAAGESWQSFLRNNAMSFRRALLRYRDGAKVHLGTRPDEKQYDTVETQLRFMTENGFSLRDGLYAISAVSHFTLGAVLEQQEHTAALTDRPAAPDENLPPLLREALQIMDSDDGEQAFLHGLESLIRGFEVQLTALLQIVGGDKLIIPFC
What is the function of this protein?
TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA.  Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
What are the official names of this protein?
Tetracycline repressor protein class H.
Protein: SURA_THIDA
Sequence: MKFFQRPERRLKQWGLALLLAASALLPARADVVPLNHIVAVVNDEVITRQELAKRYDEVVRNLSRQNTPLPPRNVLEKQLLERMVTELALQQHARNTGVRADPTLVERALQRIAAQNKLDMAGLQAALEKEGQTLDGMRNTIRNELLIARARERDVDNRISVSDAEIDGYLQTQAQQGAETEYNFSHILVSVPENASPEQIRERRARAEDILAQLAAGADFAQLSASHSDAPDALKGGNFGWRASGKLPALFVEALKPMQPGEISPLLRSGNGFHILKLVDKRGLDATLSVTQTHARHILIKTNEITSEADARNRLLQLKERIDNGVKFDELARLHSEDASASKGGDLGWINPGDTVPDFEKAMNALQPGEVSAPVQSPFGWHLIQVLERRDQDVTQERQKLMARQAIRERKAEEAFQDWVRQIRDAAYVELRPID
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: RSXC_ECO24
Sequence: MLKLFSAFRKNKIWDFNGGIHPPEMKTQSNGTPLRQVPLAQRFVIPLKQHIGAEGELCVSVGDKVLRGQPLTRGHGKMLPVHAPTSGTVTAIAPHSTAHPSALAELSVIIDADGEDCWIPRDGWADYRTRSREELIERIHQFGVAGLGGAGFPTGVKLQGGGDKIETLIINAAECEPYITADDRLMQDCAAQVVEGIRILAHILQPREILIGIEDNKPQAISMLRAVLADSNDISLRVIPTKYPSGGAKQLTYILTGKQVPHGGRSSDIGVLMQNVGTAYAVKRAVIDGEPITERVVTLTGEAIARPGNVWARLGTPVRHLLNDAGFCPSADQMVIMGGPLMGFTLPWLDVPVVKITNCLLAPSANELGEPQEEQSCIRCSACADACPADLLPQQLYWFSKGQQHDKATTHNIADCIECGACAWVCPSNIPLVQYFRQEKAEIAAIRQEEKRAAEAKARFEARQARLEREKAARLERHKSAAVQPAAKDKDAIAAALARVKEKQAQATQPIVIKAGERPDNSAIIAAREARKAQARAKQAELQQTNDAATVADPRKTAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQQQSNAEPEEQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVEAAIARAKARKLEQQQTNAEPEEQVDPRKAAVAAAIARAQAKKAAQQKVVNED
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rsx electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FXL21_MOUSE
Sequence: MKRNNFSAVNKVVQSSPVVKQPKRGLCSSLRQTHALSVLLDWGTLPHHVILQIFQYLPLIDRARASSVCRRWNEVFHIPDLWRKFEFELNQSATSYFKSTHPDLIQQIIKKHAAHLQYVSFKVDSSTESAEAACDILSQLVNCSIQTLGLISTAKPSFMNVPKSHFVSALTVVFVNSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLLKMSSCPHVSSDGILCVADHCQGLRELALNYYILSDEILLALSSETHVNLEHLRIDVVSENPGQIKFHSIKKRSWDALIKHSPRVNVVMYFFLYEEEFEAFFKEETPVTHLYFGRSVSRAILGRIGLNCPRLIELVVCANGLLPLDSELIRIAKHCKNLTSLGLSECEVSCSAFVEFVRLCGRRLTQLSIMEEVLVPDDRYTPDEVHTEVSKHLGRVWFPDVMPIW
What is the function of this protein?
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function.  Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation.  The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization.  The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation.  Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
What are the official names of this protein?
F-box/LRR-repeat protein 21, F-box and leucine-rich repeat protein 21, F-box and leucine-rich repeat protein 3B, F-box/LRR-repeat protein 3B.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus.
Protein: MSRB_ACIB3
Sequence: MGKVNKTDREWQRELSPEEYRITRQKGTEPAFTGQYWNTKQHGTYVCRCCGAELFSSDAKYDSGCGWPSFFRPLNGSVIDEHEDLTHGMVRTEIVCHDCEAHLGHVFEDGPQPTGLRYCVNSASLQLKTQEKNDEETYP
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: IPA25_SHIFL
Sequence: MIKSTNIQVIGSGIMHQINNIHSLTLFSLPVSLSPSCNEYYLKVWSEWERNGTPGEQRNIAFNRLKICLQNQEAELNLSELDLKTLPDLPPQITTLEIRKNLLTHLPDLPPMLKVIHAQFNQLESLPALPETLEELNAGDNKIKELPFLPENLTHLRVHNNRLHILPLLPPELKLLVVSGNRLDSIPPFPDKLEGLALANNFIEQLPELPFSMNRAVLMNNNLTTLPESVLRLAQNAFVNVAGNPLSGHTMRTLQQITTGPDYSGPQIFFSMGNSATISAPEHSLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLA
What is the function of this protein?
E3 ubiquitin-protein ligase effector that inhibits host cell innate immunity during bacterial infection by catalyzing 'Lys-48'-linked polyubiquitination and subsequent degradation of host RNF31/HOIP (PubMed:27572974).  Host RNF31/HOIP is the catalytic component of the LUBAC complex, which conjugates linear ('Met-1'-linked) polyubiquitin chains at the surface of bacteria invading the host cytosol to form the ubiquitin coat surrounding bacteria (PubMed:27572974).  The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:27572974).
What are the official names of this protein?
E3 ubiquitin-protein ligase IpaH2.5.
What is the protein family that this protein belongs to?
Belongs to the LRR-containing bacterial E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm.
Protein: CHDC_STACT
Sequence: MSQAAETLDGWYSLHLFYAVDWPTLRLVPDEDRIQIVQEFHDFLDKLASVRDDHNGDHALYNITGQKADILLWVLRPEMQELNSIELALNKLRIADYLVPTYSYVSIIELSNYLAGKSDEDPYENPHVKARLYPELPHSDYICFYPMNKRRNETYNWYMLSMEERQKLMYDHGMIGRKYAGKIKQFITGSVGFDDYEWGVTLFAQDPLQFKKIVYEMRFDETTARYGDFGSFFVGHVLPEETLETFFRI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: END4_CHLCV
Sequence: MQVFPPPQVPLLGAHTSTAGGLHNAIYEGQEIGASTIQMFTANQRQWRRRPLTDSLINSFKTALKETSLSYIMSHAGYLINPGSPNPEILEKSRICIQQEIQDCISLGINFVNFHPGAAVNDTKETCLDRIISSFSLMEPLFENSPPLVVLFETTAGQGTLVGSNFEELSYLIDNLNHKIPVGVCIDTCHIFAAGYDITSPESWKRVLKNFDDVIGLSYLRAFHLNDSMFPLGQHKDRHAPLGEGDIGIESFKFLMTNEDTRMIPKYLETPGGPDLWAKEIRQLQSFQK
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: ZDHC1_DICDI
Sequence: MSRPSYASATKTYFHNRLVTGPDRAYFIVAMILMLIPEIPFLIFVCPLFEEWITAAIYPVSIYFWIASYIFLIQTAYTDPGIIPRGIYNDDIFAPDHRQPLFKKITVKDTKQEIKWCETCCLYRPPRANHCGICNNCVERFDHHCPWVGNCIGRRNYQTFLYFLYSLGFLCIWIMGFCVAHICIESARYRDNHPSASSAKVFQEGMNKSHYISDYNYSLWVSRFNSNPYRKSAFANFIEAFCPPRYPSFYKYTLDHEKELTTIPTPNNINGNNNNSINNNNNNNNNNNNNNNNNNNNNNNNNNINNGNSGGTTNNGYTPPISPPQMLQRQSSTIRYSLDNLRTSSNSSLGNFNNLKSSRDLNLSTISEDKPKNLSNSNNNNNTNNKNTSEDNNHSSGSDFGGDEENNEDDFKSDNDKEINSSSLSLNHELQVNV
What are the official names of this protein?
Putative ZDHHC-type palmitoyltransferase 1, Zinc finger DHHC domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DADA_XANAC
Sequence: MRVLILGSGVIGVTSAWYLAQAGCEVTVVDRQPAAALETSYANAGQLSFGYTSPWAAPGVPGKAVKWLFEQHAPLSIRPTRDLRQLAWLSQMLRNCTAERYAVNKARMVRMSDYSRDCLNALRAETGIEFEGRQLGTTQLFRTQQQLDAAAQDIEVLAQYGVPYELLSPAQIAQFEPGLAGGGAQMAGALRLPEDQTGDCRLFTQRLAELATQAGVTFRYGQQIERLEHAGGQITGVQIDGRIETADRYVLALGSYSADVLLSLGLHLPVYPLKGYSLTIPIVDAQRAPTSTVLDESYKIALTRFDDRIRVGGMAEVAGFDMSLNPRRRATLEMVVNDLFPGGGDLAQAEFWTGLRPATPDGTPVVGATPYANLFLNTGHGTLGWTMACGSGRYLADLMQGRTPEIDTEGLDVFRYLSPRSVRPHREAA
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: KPRS_HELPY
Sequence: MKARGFKAKMRGFKIFSGSAHPAFGKEVSKHLGFPLSKAVIGKFSDGEINIQISESVRGKDIFIIQPTCVPVNDNLMELLVMVDALRRSSANSITAVLPYFGYARQDRKAAPRVPITAKMVANLMQEVGIERIITMDLHAGQIQGFFDVPVDNLYGSIVFRDYIRSKALKNPVIASPDVGGVTRARYFANQMGLDLIIVDKRREKANESEVMNIIGSAKERDVILVDDMIDTAGTICKAALALKEQGATSVMALGTHAVLSGNAIKRIKESALDEVVVTNSIPLVQKCDKITTLSVAPLFAEVIRRIYHNESVQSLFT
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTA1_AZOBR
Sequence: YRTIDRIYPALTREHKLLIPDIKGEAHIVYEEGRLYPHHNLYYITSEIWDLRALQAVLLSGIARLFVSVYSTKMHGGFLRFQAQYLRRIRVPNWSQVPAAVRQELITAGAKPDLAACNRAVFALYAMTAEERAALGGNGD
What is the function of this protein?
A methylase, recognizes the double-stranded sequence 5'-CTCGAG-3', methylates A-5 on both strands, and protects the DNA from cleavage by the AbrI endonuclease.
What are the official names of this protein?
Type II methyltransferase M.AbrI, M.AbrI, Adenine-specific methyltransferase AbrI, Modification methylase AbrI.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: RL17_BURM1
Sequence: MRHRHGLRKLNRTSSHRLAMLRNMSNSLIEHEVIKTTLPKAKELRKVVEPLITLGKKPSLANRRLAFNRLRDRDSVAKLFDVLGPRFANRPGGYLRILKFGFRVGDNAPMALVELLDRPEVDETENVQEAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PMA4_ARATH
Sequence: MTTTVEDNREVLEAVLKEAVDLENVPIEEVFENLRCSKEGLTTQAADERLALFGHNKLEEKKESKFLKFLGFMWNPLSWVMEAAAIMAIALANGGGKPPDWQDFVGIITLLVINSTISFIEENNAGNAAAALMARLAPKAKVLRDGRWGEQDAAILVPGDIISIKLGDIVPADARLLEGDPLKIDQSALTGESLPVTKSSGDGVYSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDTTNQIGHFQQVLTAIGNFCICSIAVGMLIEIVVMYPIQHRAYRPGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTVDKNLIEVFMKGVDADTVVLMAARASRLENQDAIDAAIVGMLADPKDARAGIQEVHFLPFNPTDKRTALTYIDNEGNTHRVSKGAPEQILNLAHNKSEIERRVHAVIDKFAERGLRSLAVAYQDVPEGRKDSAGGPWQFVGLMPLFDPPRHDSAETIRRALNLGVSVKMITGDQLAIGKETGRRLGMGTNMYPSSALLGQNKDESIVALPVDELIEKADGFAGVFPEHKYEIVKRLQARKHICGMTGDGVNDAPALKKADIGIAVADATDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVLGFMLLALIWQFDFPPFMVLIIAILNDGTIMTISKDRVKPSPLPDSWKLSEIFATGVVFGSYMAMMTVIFFWVSYKTDFFPRTFGVATLEKTAHDDFRKLASAIYLQVSIISQALIFVTRSRSWSFVERPGIFLMIAFILAQLVATLIAVYANWSFAAIEGIGWGWAGVIWLYNIIFYIPLDFIKFFIRYALSGRAWDLVIEQRVAFTRQKDFGKEQRELQWAHAQRTLHGLQAPDTKMFTDRTHVSELNQMAEEAKRRAEIARLRELHTLKGHVESVVRLKGLDIETIQQAYTV
What is the function of this protein?
The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport.  The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).
What are the official names of this protein?
ATPase 4, plasma membrane-type, Proton pump 4.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TGB3_PVX
Sequence: MEANTYLNAIILVLVVTIIAVISTSLVRTEPCVIKITGESITVLACKLDAETIRAIADLKPLSVERLSFH
What is the function of this protein?
Plays a role in viral cell-to-cell propagation, by facilitating genome transport to neighboring plant cells through plasmosdesmata.  May induce the formation of granular vesicles derived from the Endoplasmic reticulum, which align on actin filaments (By similarity).
What are the official names of this protein?
Movement protein TGBp3, 7 kDa protein, Triple gene block 3 protein, TGBp3.
What is the protein family that this protein belongs to?
Belongs to the Tymovirales TGBp3 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane.
Protein: CH10_LACH4
Sequence: MLQPIGDRVIVKVKDEEEKTVGGIVLASNAKKKPTEGEVVAVGEGAYASNGEKIPMSVKKGDVVLYDRYSGTNVEYEGEKYLVLHEKDILAIAK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEE2_LEPIN
Sequence: MELWLDEALELKNGRALKIKVKEFLHSRTTPFQKIDVFESVGFGRMFTLDGVVMMTEADEFAYHEMIVHVPMMSHPNPEKVLVIGGGDGGTVREVLKHPSVKEVHLCEIDKGVIDVCYEYFPEIANAMKDPRVKHAYEDGAKYVKDYQNYFDCIMVDSSDPVGPAEVLFKRPFYETMANCLKEGGICTTQGESFYYHGSIIRELFNFIPEIFKHCGYYYTVVPTYPSGIIGFTYCSKGPDPYTVVPDPQRVPQGLKYYSAEMHKAAFVLPQFAQKHIVRK
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase 2, Putrescine aminopropyltransferase 2, PAPT 2, Spermidine synthase 2, SPDS 2, SPDSY 2.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYQ_DROME
Sequence: MAGDDLIAKFQALGMSEQKAKETLKNANVTKNLQLSLAAAGSATLSDGTGMLIYHMATKLKPQTADHLPLLVRYIVEHKLDNTQRVDAALEYLLKCGQSLNANIDLQALEKECGVGVVVTPEQIERTVQAKIKASYKEALLEQRYHFNSFKILQDVRGELKWADAKSVKAAIDVEIFDLLGPKTEADLKPQTKANDKPKAAKPKAEVTPAAQTAEAASDGATTISELMKTKVHFHAPGENFKADGYVVTEHTERLLKEHLARTGGKVHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKFFLAIKEMVEWLGYKPFKITYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELKGFNPKPSPWRERPIEESLRLFEDMKRGKIDEGAATLRMKVTLEEGKMDPVAYRIKFISHHRTGSDWCIYPTYDYTHCLCDSLEDITHSLCTKEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVSKRKIAKLITEQIVHDWDDPRLFTLTALRRRGFPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDVLNVTAPRRLVVLEPLKVTIKNFPHAAPVQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLEPEKGYRRLAPKQSVGLRHAGLVISVDEIVKDPATGQVVELICTSQPAEQAEKPKAFVQWVSQPIQLEVRLYEQLFKHKNPEDPNEVPGGFLSDISEQSMSVVVAFADRALNQAKVYDKFQFERIGFFSVDPDTSANHLVFNRTVGLKEDAGKK
What are the official names of this protein?
Probable glutamine--tRNA ligase, Glutaminyl-tRNA synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein: ACTP_ECO5E
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRNDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMMGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSITVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MCM6_DROPS
Sequence: MDVADAQIGQLRVKDDVGIRTQKLFQDFLEEFKENGEIKYTRPAANLESPDRCTLEVSFEDVEKYDQNLATAIIEEYYHVYPFLCQSVSNYVKDRIGLKTNKDCYVAFTEVPTRHKVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGTFMCLDCQTEIRNVEQQFKFTNPTICRNPVCSNRRRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAMPGTRAESGSRHKPGEGMEGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLITCLFPSIYGNDEVKRGILLQLFGGVAKTTIEKTSLRGDVNVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDLRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNIEESVERAYSREEVLRYVTFARQFKPIIGQEAGKMLVENYGHLRQRDTGTAGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLNKSIIRVEQPDIHLDDDDDLDVDDGIQDDIDMENNGSAANTETDTLDTSGASTVQKKKFTLSFEDYKNLSTMLVLHMRGEEARCEVEGSDSGMKRSDVVTWYLEQVADQIESEDELISRKNLIEKLIDRLIYHDQVIIPLKTSNLSRIKGPAEEQVDNDPLLVVHPNYVVD
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
What are the official names of this protein?
DNA replication licensing factor Mcm6.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Note=Associated with chromatin during cell cycles.