PharMolix/UniProtQA huggingface dataset:
Protein: JV_DROME
Sequence: MGNGYFRTSQTSSSSRQREKRGKDSYSYQHNYVDRVRLEDTTGGHYHNNQHQQTTHDPRCPQLRAAGWRHTHKSVSHLDLATSCHDAAGTGLGRHSQQLHHHHSNQVNQHHHQQQQSHHHLQHANLHSHHPHAQPHWTQCRVGGAGSGNGQLRNARSLDYTQLEREENALDIAEFYWRFDAEAPLDQVDSYAVLPINDNFEPSAATSTAVGSKETTTTVANKANGSATTNATTAAANALLDILGSESCSLRRSRSLAVIREETFSDLQIGSANSSRRRSQLIPRARLVNRGFFRESPRSRHKFQFKQFKKKPPAKLLRLNGKPNQATLVGEQPADQPTADDTQSQRSNSATCDSHQQQQQQQHQPQQQHQQQQHRLSGESRDFDVYYDNLKRLDALALNLSEQLHPWHNDKSDLESLNSDYFKNSLHQNHLDQQQPSSLEFEALEQVAASLLKERPRIYQSRRQQQKRNNHHSNCLQRHLDTGGESCPEHSQSSVFPETTTSNSDDQTDSPSLSEQEYDLTHIEEIYQQGNNGEESYEIISLTTTTRTRFESSEEGEEEQTGEEVVDSLTTPTEPQTSDSESTLRQNHNEQLDKLIAYDSVYLSSEDSSDCTLVGESCESFEQRTFTSCGESGELETRSLLHISIEDTVYEPQAKQHKKATNQEDQPAPLLTTTAKVEAQIFTQVLKVEHTPKPNILAVVEKRKLKQEEVKHQPPELKRQATDSFVVTANKSNLAENQYHSLPDVNIGVSLKVCESIDKELRSSYNQQRQQQRKEAKKEQQVTRAETYDSIRRFGRAHQKARQREYQEREREREKEASAALQEKDKEREREKPKINKEFSAQERQIEVKETTKSQDIIKEKEQVSRKEEAEDDEEEEPLPPPPPPLTEESQQEDTVADVEEEDNLSVSISQPEQPKEAPVIEVANFSKLIERRAQEIRERQEQIKPSFQIIVTDAQNNIIQKEAIQENKETSQRIEPKPSPKTNSNSSSTCNLVQRPLRRSVSSSSGKPLEHRILSTGAPIYKARPVRVLPSSSSDSSFSRGKMSRPQILHVVDGRGGVAGGGAGGTLRRRSSARSIASTISSPGGEVANEYLQKVDAVRCYWNKLAGNEPETLKTEQPAKETQPGIHFQLGGETTTQGTDKSAVGNDFCSMMPHPSIEIVELGEGAQKATIVKAAPEREEDPDEDQDQFDHIRYKVLKSQQLIRNNFLSTRNKKEAQFDGLIQYLQEYSFQELLSNNNVVIVEPVRTKIERPLQVGINSGSTTTPTTVPPPKPPRVVNASASQPRKTRQKQTGGAAAKRHFFYQPVRVNRELYEDELPDPDTVRNVRRFFEQNVLPTPGQGLLVQSQQKFGGSACQLSPKSRRARGYRYLTIDTSYGGAEEQPKGMEMLEEHKAKHWDNASLSSGISSGVLSSPCGEYHHQESPVMACKDVHVQDVVRRHNSNAANAKARAKFASRRTWCMGAGGPGANESLYRQIYENNLGNSEQQENGEHLEEEDDEQDDQYEDDVEQDMCENYYVSNDVLAKIRECGSTVTYYGGRVLDKTATSTAAPSTKTTQPMTGSATRSRIRQIEACNVCLPSERCEHRLQTKQAAAKQQQDSYQGIKFKLVKSNSCSSRLELAGTGEDEVTADSEVVRKMVHHFEANQTTASNDVQVTINSQSQITSTKKEPEEDVPRRQVTVNNHINVLGDTMPQASQEKAENFNGRPEENGYGAVETVPTYESQAMNIRLDATENKNILQTAAATAAANKVCRNKNVDLAYTLVKTTTNSPKGKPIEAPRQKIGKQLREVEENVEKAAVTKATIKLTKGAPSQIIVPVDIHSQASIVAHTAPIPERRLSNASSSNSVVDKTVVRHYVANDKSIYERRKYDEIEFEEFEVYDPSKEPPPQVEEGTDKIPTDAELYDSLDDKM
What is the function of this protein?
Important for normal assembly of actin bundles during bristle formation.
What are the official names of this protein?
Protein javelin.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Colocalizes with actin filaments.
Protein: COX20_SCHPO
Sequence: MSTPNEPEKPGIIDAFKSLKMSDFAHMVHHPCFKESLITSVVCGLGVGCIHLFLRAPISRAANWGFGTYFGMSIVSWEGCNYRKQLETNNFNIKITEAAEKTPKHRSSRSAQEIDEGFNE
What is the function of this protein?
Involved in the assembly of the cytochrome oxidase complex.  Required for the maturation and subsequent assembly of the mitochondrially encoded cox2, the precursor of subunit 2 of cytochrome oxidase (By similarity).
What are the official names of this protein?
Cytochrome c oxidase assembly protein cox20, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX20 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: CALM_WHEAT
Sequence: MADQLTDEQIAEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQDGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: NU3C_GLOVI
Sequence: MFVLSGYDALLIFLLLSALVPVLALTISYLIRPKGSGAFRTTTYESGVDPRGDSWIQFNIRYYMFALVFVVFDVETVFLYPWAVAFNQLGLLAFIEALIFIAILVVALVYAWRKGALEWT
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RODA_MYCTO
Sequence: MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQDQGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLVDNEIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPALLPAALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGMTLPRPRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTLFAAGTLVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQPDTVPAASTDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLSSTLAIQLFIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRTRPRNKSPITAAGTEVIERV
What is the function of this protein?
Transglycosylase involved in peptidoglycan cell wall formation.  Required for the regulation of cell length.
What are the official names of this protein?
Peptidoglycan glycosyltransferase RodA, Non-canonical transglycosylase RodA.
What is the protein family that this protein belongs to?
Belongs to the SEDS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: D19L4_HUMAN
Sequence: MAEEEGPPVELRQRKKPKSSENKESAKEEKISDIPIPERAPKHVLFQRFAKIFIGCLAAVTSGMMYALYLSAYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINAVQQMSLYPELIASILYQATGSNEIIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRIEYSIPLRENWALPYFACQIAALTGYLKSNLNTYGERFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEQSDKVYEVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQLNVKKGSFVAKIIKVINFYLVCTLTITLNIIMKMFVPHKENGHMLKFLEVKFGLNMTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRINGKSLKETVTLEDGRIGERPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPILLALILSMAVPTIIGLSLWKEFFPRLMTELMELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDDLLKRNENIYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGPMRGCRVKDLLDIANGHMVCEEGDKLTYSKYGRFCHEVKINYSPYVNYFTRVYWNRSYFVYKINTVISFQS
What is the function of this protein?
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
What are the official names of this protein?
Probable C-mannosyltransferase DPY19L4, Dpy-19-like protein 4, Protein dpy-19 homolog 4.
What is the protein family that this protein belongs to?
Belongs to the dpy-19 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ASTE_ECOSM
Sequence: MDNFLALTLTGKKPVITEREINGVRWRWLGDGVLELTPLTPPQGALVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRGSLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQEPGGTFTHFSARHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMANDTLNFMPFEKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: YBED_ECO81
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: CP9E2_BLAGE
Sequence: MMSLESLWLWTFAISFIVLIAYLIGTWNHDFFSKRNIPSLKTVPFLGNMGPLVLRKASFAEHSQNIYNRLKGYKYGGMFEFMNPVLVLRDPELIKMVTVKDFEYFLDHRAPISEEAEPMFGKNLFNLRGHRWKEMRSTLSPAFTSSKMKNMFVLVSECGKQLGEFLMECSRDKNKKTEGCKIEREGDLLTVELKDLYTRYTNDVIATSAFGIGCDSLKNPKNEFFQMGKDVTNFGGIRQFIFLGYLFSPRLMKYLNLKFLSSKATEFFRFLVHNTMDTRKTKGIIRPDMIHLLMQAKEGTLKSEENGETNGKIASKPKWDDDDLTAQAVLFFFAGFDTASTLLCFMSHLLATNPDVQNRLQDEIDQSLEENDGKLTYEAIHSMKYLDMVVSESLRLYPPAIFTDRKCVKNYRLPMEPSYTLEPGDAVWIPIYAIHHDPKYYPNPEKFDPERFSDENKDNIKPFTYLPFGSGPRNCIGNRFALMESKIALVHLLCRFNLKVVSKTPIPIKITKKGFNMTVDGGFWLGLEERTNQ
What are the official names of this protein?
Cytochrome P450 9e2, CYPIXE2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: MOPB_PECCC
Sequence: MAIASISSPAPVASQQSTLVTEPPLTSSMLLTQVGSVLAGILLFILLIAWLARKLGFAPQAKQNKLLKVVSSCPVGQRERVVIVEVDNTWLVLGVTAQQITPLHTLPAQPTNDSSSTGDTKPVDFNQLLKKVLKRPEKSE
What is the function of this protein?
Required for both, motility and virulence.
What are the official names of this protein?
Protein MopB.
What is the protein family that this protein belongs to?
Belongs to the FliO/MopB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Bacterial flagellum basal body.
Protein: RIMO_CLOBM
Sequence: MEKIKVALVSLGCDKNRIDSELMLYKLNEEAELVKDPKEAQVIIVNTCGFIETAKEESINTILQMASYKKTHNCKVLVVTGCLTQRYKGELKELIPEMDIMLGVNDYDKLLESIKVFLKSGEKSFYHKYSDTKINEGNRILTTPTYTAYVRIAEGCNNFCTYCAIPRIRGKYRSRKKENILKEVENLAKQGVKEIILIAQDTTMYGIDIHGKKVLHELLRDISKVEGVKWIRLLYCYPEEITEELIEEIKNNDKVCKYLDLPIQQISNSVLKRMGRKTTKETIINIIKKLRKEIEGITLRTSLIVGFPGETEGEFSELKEFVSDIKLDKLGVFKYSKEEGTSAALMEEQIDEEIKEKREEEIMILQQSISKDINKEKIGKIYEVIVEGIKEDMYYGRNYEMSPEIDGEIYFEKDENVKIGDIIKVKVTHSLEYDLIGVVYNELSK
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_STAAM
Sequence: MITAEKKKKNKFLPNFDKQSIYSLRFDEMQNWLVEQGQQKFRAKQIFEWLYQKRVDSIDEMTNLSKDLRQLLKDNFTVTTLTTVVKQESKDGTIKFLFELQDGYTIETVLMRHDYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVSQVLTVQKALDATEERVSQIVIMGIGEPFENYDEMMDFLRIVNDDNSLNIGARHITVSTSGIIPRIYDFADEDIQINFAVSLHAAKDEVRSRLMPINRAYNVEKLIEAIQYYQEKTNRRVTFEYGLFGGVNDQLEHARELAHLIKGLNCHVNLIPVNHVPERNYVKTAKNDIFKFEKELKRLGINATIRREQGSDIDAACGQLRAKERQVETR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  Confers resistance to some classes of antibiotics.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGTS_ECOLI
Sequence: MLGNMNVFMAVLGIILFSGFLAAYFSHKWDD
What is the function of this protein?
Modulates intracellular Mg(2+) levels to maintain cellular integrity upon Mg(2+) limitation.  Acts by binding and stabilizing the Mg(2+) transporter MgtA, thereby leading to increased intracellular level of Mg(2+).  May inhibit FtsH proteolysis of MgtA.
What are the official names of this protein?
Small protein MgtS.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PYTA_ASPTN
Sequence: MDPQQRLLLEVVYEALEDAGITLDEIQGSLTSVYCGCFTNDYNAMTTKDLEYYPKYTVTGTGNSILANRISYFYNLHGPSATVDTACSSSLVCFHLGAQSLRDAEADISIVVGSALHFDPNIFITMTDLGMLSTDGRCRHGDAAGSGYVRGEGIAAMVLKRQDRAQADGDHIRAVVRGTGVNHDGRKQGITLPSARAQADLITSTYERAGLEPAETTYVECHGTGTKAGDPRELRAVHEVFCRHRPDTLHVGSVKTNIGHLEGASGIAGLMKATMALEKKIIPPNMHFSTPNPEVDFKNWKLEIPTEPKVWEMGRRTIPRRASINSFGYGGTNAHAILEEYNSFGSKTTACQQPTVSLPPELAAMVERRPYLLPLTSHSERAGELWAERLAQYLTENEASVADVALSLSTRRTMHRFRSFAVSADMEKVIERIRDPPPGAAWKSKLDTIPRIGFVFTGQGAQWFGMARSLLEQCPLFLQTIRKCDRILQALPSHRPTWSVEAELLKSQQDTMLGRTEYSQPICTAVQLALVDVLAHWGVKPSGVVGHSSGELAATYAAGLLSFENALVAAYYRGVHMGSGAAAPGSMPGAMMAVGMTEAEVTAELEPYRGRIAIAAMNSPSSFTVSGDEDAVVELQQALTDRKVFARRLQVAQACVFVHSLVIKRY
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of pyranterreones, a family of antioxidative compounds (PubMed:32077283).  The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase pytA that condenses 4 malonyl-CoA units ato the acetyl starter unit by the modular PKS of pytA (PubMed:32077283).  The acyl chain is then connected to an L-serine through the amide bond by the modular NRPS of pytA (PubMed:32077283).  A tetramic acid is formed and released from the PKS-NRPS pytA to give pyranterreone 5 with the help of the thioesterase pytI (PubMed:32077283).  Pyranterreone 5 could be methylated by pytC to afford pyranterreone 6 (Probable).  Both pyranterreones 5 and 6 are subsequently oxidized by the FAD-linked oxidoreductase pytB and the cytochrome P450 monooxygenase pytD to form the fused gamma-pyrone core, resulting in pyranterreones 7 and 11, respectively (PubMed:32077283).  The hydroxy group at C-8 of pyranterreones 7 and 11 are dehydrated by the aspartyl protease pytH to form a delta-7 double bond to give pyranterreones 3 and 1, 2 accordingly (PubMed:32077283).  The exo-methylene of pyranterreone 3 could be reduced into a pendant methyl by reductase pytE to provide pyranterreone 4, also known as cordylactam (Probable).  Pyranterreone 4 can be reconverted to pyranterreone 3 through pytB-catalyzed dehydrogenation or further oxidized to pyranterreones 9 and 10 (Probable).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase pytA, Pyranterreones biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.
Protein: DPO3X_BUCAP
Sequence: MNYQILARKWRPQSFKKIIGQKYIVKAISNGFSLGKIHHAWLLSGTRGVGKTTIARLIAKSLNCEIGITSLPCRKCTICQEIEKGICLDFIEIDAASRTKVEEIREILDNIYYTPSKSRFKVYLIDEVHMLSRHSFNALLKTLEEPPQHIKFILATTDVEKIPKTIRSRCLHFKLNILSEEDIFNFLKHILKKGGNNFDEEALKIISDYANGSMRDALNLLEHAMHLSKNNINLKNTTEMLGIPNKKHAFLLTKFLLEQDSKKMMCLLNKISKIGLEWQNILIEMMRFLHHIAMLKSYPKIWNQIFIKNNENEIKKIAENNSKYNIQLCYKILLKGRKELFFSPNHKMGVEMILLQAITEIKR
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the DnaX/STICHEL family.
Protein: NLP4_PLAVT
Sequence: MSRTMQSKRMQNSVAGMPNHSLFLLLPHTRMQFAVFCLLALGNFAYADNIHHVINKLPYDKIKPFPPVQPDCQINEIALQFQPQLHISSGCHPYPAVDAKGYISNGLGVSHTFTDCDGSPEGSQVYGRAYVFKGYLAIMYAWYFPRDYMVTPVWVGHRNAWEHAVLWINDMDDDPKLLAVAAKSMVGYKTYSPPKSKYMDDDSFKLKYKWMVVSHHYLAATKDKGEFQDLIMWDNMTENARISTGPQGWSHYQSPLGDDRFFRALHESYPF
What is the function of this protein?
Secreted effector that acts as a pathogen-associated molecular pattern (PAMP) recognized by the plant immune system (PubMed:35152834).  Seems not to induce necrosis in Nicotiana benthamiana leaves but significantly improves disease resistance of Arabidopsis thaliana to Hyaloperonospora arabidopsidis and causes an inhibition of plant growth which is typically associated with enhanced immunity when over-expressed in Arabidopsis (PubMed:35152834).
What are the official names of this protein?
NLP effector protein 4, Nep1-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the Necrosis inducing protein (NPP1) family.
Protein: NS1_I34A0
Sequence: MDSNTVSSFQVDCFLWHVRKRFADQEMGDAPFLDRLRRDQKSLRGRGSTLGLDIDTATRVGKQIVERILEDESDEALKMTIASVPATRYLTDMTLEEMSRDWFMLMPKQKVAGSLCIRMDQAIMGKNIILKANFSVIFDRLETLILLRALTDEGAIVGEISPLPSLPGHTDEDVKNAIGVLIGGLEWNDNTVRVSETIQRFAWRSSNENGGPPLPPKQKRKMARTIESEI
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: MSCL_ECOUT
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLREAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAATPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IR222_CANAL
Sequence: MKLSTIFTAFAATIATVAGYETTGSKQTVDILIDYIIKETPELSQNDVANWENGDTVTLQYVVNNNEESEITVVGVTGQFKNPINNEIVTNLTTGKVGPIAVPPGEAIKFDQKINVDLIPANYELIPHVFIAQDSLIKVIPCRGQLATIVDAAVSFFDPRLIFLELVLLITFAGLIYVGYEIWGKQYFKGVAPVKAKKVSAAKASSPVATGPSTTSATGYDTNWIPESHLKQKKTKKVN
What is the function of this protein?
Is probably involved in a pathway contributing to genomic integrity.
What are the official names of this protein?
Increased recombination centers protein 22-2.
What is the protein family that this protein belongs to?
Belongs to the IRC22 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: UB2E2_MOUSE
Sequence: MSTEAQRVDDSPSTSGGSSDGDQRESVQQEPDREQVQPKKKEGKISSKTAAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSPDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.  Catalyzes the ISGylation of influenza A virus NS1 protein.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 E2, E2 ubiquitin-conjugating enzyme E2, Ubiquitin carrier protein E2, Ubiquitin-protein ligase E2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: HLH13_CAEEL
Sequence: MTASSSGCGGLPVSQCPSYSSLSKLFFMDSSYDSYYCEEPEERQTASIRERKRMCSINVAFIELRNYIPTFPYEKRLSKIDTLNLAIAYINMLDDVLRTPEDSGQYIQKCVHMARTGQIGAPAWSTSDLLARLNWIKWRRLGIEPIA
What is the function of this protein?
Transcriptional activator (By similarity).  Shown to have a role in the negative regulation of exit from L1 arrest and dauer diapause dependent on IIS signaling (insulin and insulin-like growth factor (IGF) signaling).  Hypodermal expression is regulated by IIS/daf-16 while neuronal expression is not under the control of IIS/daf-16.
What are the official names of this protein?
Helix-loop-helix protein 13, Fer3-like protein, Nephew of atonal 3.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CARA_STAES
Sequence: MLEKRYLVLEDGSYYEGYRLGSDDLSIGEIVFNTAMTGYQETISDPSYTGQIITFTYPLIGNYGINRDDFESLTPKLNGVVVKEASTHPSNFRHQKTLHETLAQYHIPGISGVDTRSITRKIRNYGVLRAGFTDNKDNIQELVEQLKTAELPRDEVQTVSTKTPYVSTGSDLSVVLLDFGKKQNIVRELNLRGCNVTVVPYDTSAEEILGMSPDGVMLSNGPGDPDEVDVALDMIRGILGKIPFFGICLGHQLFALSQGATSFKMKFGHRGANHPVKDLRTGKIDITSQNHGYSIDCDSLKNTDLEVTHIALNDGTVEGLRHKELPAFSVQYHPEARPGPSDSNYLFDEFIAMMKDFKEKERQINA
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: METJ_PHOLL
Sequence: MAEWNGEYVSPYAEHGKKSEQVKKITVSIPLKVLRILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERNDEIPEEAKKIMRELGIDPDTWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_CARHZ
Sequence: MGMLIKNGNVVMVEDGKIRKMDVLIDKGIIVEISPEINRSDVEVIDIEGKFLIPGLIDMHVHFRDPGYTHKEDIHSGSNAALAGGFTGVLMMPNTDPPPDNATVIYYWKEKSKSIPLNILFSGCITKNRAGKELSKFYELKEAGAVAITDDGNWVADGAVFRHAMEYAAALDLLVITHPEEPTIANRGVINEGYWSTVLGLRGIPKAAENIAIYRDIEIAKMTGAKLHVAHLSTAEGVRLVAAAKKLGLKVTAEVTPHHLVLTDEALAGYDTNLKVNPPLREAEEQKALLKGLLEGVIDVIATDHAPHASYEKNVEFNDAPFGIEGLETAFPVLYTELVLKKKITLEKLLLKMTVNPAKILQLPKQGDIKKGNYANLTVIDPKLTLKVSEELLVGKSKNNPFLGRTLTGWPVMTVYQGIVAYQRLLKGVQ
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: NADD_LEGPH
Sequence: MHSIAIFGGTFDPVHNGHIKTSLAIQANFGFDSYYFLPCKSPAIKPPSFASSEQRVEMLKLALKPYPDFKIDTRELDRDTPSYMVYTLQSFRQEYTDSSLTLIIGYDGLLNLPQWYQWEKIISLANLLVINREEFFQQPVPKSVQTLLNQYRNDDKNILLNHHAGSICLYNAGHYDISSTKIREQLKQHKDVKNNLPDLVYDYIKKQELYQ
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: H2M01_CYRHA
Sequence: MKVTLIAILTCAAVLVLHTTAAEELEAESQLMEVGMPDTELAAVDEERLFECSVSCEIEKEGNKDCKKKKCKGGWKCKFNMCVKA
What is the function of this protein?
Postsynaptic neurotoxin.
What are the official names of this protein?
U4-theraphotoxin-Hhn1e, U4-TRTX-Hhn1e, Hainantoxin-II-13, HNTX-II-13.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS7_MANSM
Sequence: MTQQPTLFIDRDGTLIDEPKTDFQIDSLEKLKFERNVIPALLKLKNRYRFVMVSNQDGLGTDSFPQEDFDKPHNAMLAVFRSQGIEFDDILICPHKPEDNCDCRKPKIKLLKKYIDKKLFDPADSFVIGDRPTDVQLAENLGIRALQYHPENLDWDMIAEKLLREPVADPKGLGQPRHAVVARKTKETDIKVEVWLDEAGVNQINTGIGFFDHMLDQIATHGGFRMNVSCKGDLHIDDHHTIEDVALALGAALKEAIGNKRGIQRFGFVLPMDECKAECALDLSGRPYFKFKAKFNRDKVGDFSTEMTEHFFQSIAYTLLATLHLSVKGDNAHHQIEALFKAFGRTLRQAIKIEGNEMPSSKGVL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.