PharMolix/UniProtQA huggingface dataset:
Protein: SUI1_CENSY
Sequence: MAVICNTCGLPEDLCACGDLAKDSTKIIIRLETRRFKKKGTMIEGLDPKLNNLENVAKELKNKYACGGTAKEGYVFLQGDHRDTIKDTLVGLGFPESSIELH
What are the official names of this protein?
Protein translation factor SUI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: CSF2_CAVPO
Sequence: MWLQNLLLLGTVVCSICAPTDLLSPVTQSWKHVDATINEALSLLNHTSDPAAVMNETVEVVYDQFEPQEPTCLQTRLALFMKGLRGNLTRLEGSLTLMANFYKQHCPPTPETSCMTQIITFKSFKENLKRFLFAIPFDCW
What is the function of this protein?
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
What are the official names of this protein?
Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony-stimulating factor, CSF.
What is the protein family that this protein belongs to?
Belongs to the GM-CSF family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1043_CHLAA
Sequence: MSGHSKWHTIRRTKGVNDQRRGQLFTKLARDITIATREGGSGDPDLNFRLRLAIEKARANNMPNENIQRAIDRGLGKSNEAALEEIFYEGYGPGGVAILIEAATDNRNRTNSEVRATFNKNGGNPGEPGSVSWMFEQKGLITIDLSAVKHDPDELQLMAIDAGADDVVVDDETLEIYCDWTQLNAIRQALLDQGVPVANAEKIMRAKTLIQPDEKDALAALRLIEKLEDLDDVQKVYSNLDITAELVARFDA
What are the official names of this protein?
Probable transcriptional regulatory protein Caur_1043.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y542_PSYCK
Sequence: MYFLLSPAKSLNETDTAPMDISSYYSQPELIEHSQALMKILKSKEPIDLQELMSISDDLSQLNAKRNQDWAWSDNELFTDDNAKPAGYLFDGDVYTGLDMYNMDKDTAIYVNEHLGILSGLYGVLKPLDFIQPYRLEMGTKLKNERGDNLYEFWGEEVTKIINKRMADSDDKVLINLASNEYFKAVKKKALNAEIITPRFEDEKNGQYKVISFYAKKARGLMVKYAADNKLTNAEQLKQFDLAGYYYCETASDDKTWTFRRDEVNQ
What are the official names of this protein?
UPF0246 protein Pcryo_0542.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: PYRC_METKA
Sequence: MLALRVLLKGKILIGGRVREREVLAEDGWIVKIGKRLNEEADLTLELGKRELAVPAPIDLHVHCRDPHPDYPFGFKTETRRFLLGGVATVVDMPNTRPAPTTPETYYEKEELARENAEIEVIVAGGVRDSQCTKELVEAGAYVLGEVFLATSTDAPAVPWSTLPEIFRELSPDGPLTIFHPELDELVAERPARNLYEHLKNRPPEAETTAVGLLAGLKVRYPSRIHLSHVTLPESVKIAKGADITVDVTPHHLFFDVLRVDPEDPVFKVNPPLRGRHHRLGLLRAVRRGDVDVLASDHAPHILEDEFEDVPSGVTGGEIILPAALTLHRRFGLSLRDAVAMITCRPAKLLGRDDLGEVAVGKRARITVVRMREFVVRAEEFGEEDRKFPYDGMRMFGEPVKLIDGTKVYDLKESRREGKPVILEGE
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: BAMA_YERPS
Sequence: MAMKKLLIASLLFGSATVYGADGFVVNDIHFEGLQRVAVGAALLNMPVRVGDTVSDDDIGKTIRALFATGNFEDVRVLRDGNTLIVQVKERPTIASITFSGNKAVKEDMLKQNLEASGVRVGEALDRTTISNIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFTEGVSAKIQQINIVGNHSFTTDELISRFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSFYLDRGYARFNIDSTQVSLTPDKKGIYVTINITEGPQFKLNSVIVSGNLAGHQSEAEKLTKIEPGELFNGSKVTRMEDDIKKMLGRYGYAYPRVVTQPEINDDDKTVKLHINVDAGNRFYVRHIRFEGNDTSKDSVLRREMRQMEGAWLGNDQVEAGKERLNRLGYFETVDVETQRVPGAADLVDVTYKVKERNTGSLNFGIGYGTESGVSFQVGVQQDNWLGTGNTVGINGTKNDYQTYAEFTLMDPYFTVDGVSLGGRIFYNDFKADNADLSGYTNSSYGADGTLGFPINENNSLRVGVGYVHNDLSDMLPQVAMWRYLESVGERPGYDGREGFTTDDFTLNLGWTYNNLDRGFFPTSGVKSSVNTKITVPGSDNEFYKVTFDTSAYQPLNEDRSWVLLGRGRLGYGDGIGSKEMPFYENFYAGGSSTVRGFRSNNIGPKAAYYANGGATVTNSTDAVGGNAMAVASIELITPTPFISEKYSNSVRTSIFIDSGTVWDTNWENTAKTRAAGIPDYGKASNIRVSAGVALQWMSPLGPLVFSYAKPVKDYEGDKSEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: MDTH_ECOL5
Sequence: MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCLLSGLGGTLFDPPRSALVVKLIRPQQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLCAAFNAWLLPAWKLSTVRTPVREGMTRVMRDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDVAGAPSAVKWMYAIEACLSLTLLYPIARWSEKHFRLEHRLMAGLLIMSLSMMPVGMVSGLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDLGKSAHQPELPWMMLGIIGIFTFLALGWQFSQKRAARRLLERDA
What is the function of this protein?
Confers resistance to norfloxacin and enoxacin.
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL32_AERPE
Sequence: MAGGEPQSLEEAFAARRNVLAARRARERLRRLIASKSRHRFLRYLSWRFWKFERRDYWRKPKGNDNKMRLQLKGYPPIVKVGYRTPKAIRGMHPSGLEPVIVSSAKDLERLSPERHIVYIASGVGLRKKQEIRRAALERGFRVAN
What are the official names of this protein?
50S ribosomal protein L32e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: CITD_VIBCH
Sequence: MKIAHPAFAGTLESSDLQVRIEPNNDGGIELVLDSTVEQQFGHAIRQVVLHTLDAMQVRDALVTIEDKGALDCVIRARVQAAVMRACDVQNIEWSQLS
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLDD_NEIMF
Sequence: MTIIVTGAAGFIGSNIVKALNQRGITDIVAVDNLSKGEKFKNLAECEIAHYLDKHEFIRQVREHILPYQNIEAVFHQGACSDTMNHDGLYMMENNYQYTLDLLNWCQDERIPFLYASSAAVYGKGEIFREERELEKPLNVYGYSKFLFDQVLRRRMKEGLTAQVVGFRYFNVYGQHEQHKGRMASVTFHHFHQYREHGYVNLFGSNDGYGNGEQTRDFVSVEDVAKVNLYFFDHPELSGIYNLGTGRSQQFNELAAATVNACRAAEGKPEMSLKELVEEELIRYIPFPDALKGKYQSFTQADITKLREAGYKEEFFDVKSGVDRYVKWMLENLA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: RF2_LEPIC
Sequence: MEVKSAKELKRISKELQENFLNRWKLLNLEQDKDRLKSLTEKAEDPNLWNNPEEARLVSQKKNELEKKLNPWFTIQQDILDFPDLVDLTLDEKGENGVGELSSEYNRLQEKFEELELLGALKNPEDLKPAFLNIHPGAGGTESQDWAEMLLRMYTRYFEKKGYQYSLIDVQAGDGAGIKNATLHVIGDFAFGFLKGENGVHRLVRISPFDANKRRHTSFVSVHVSPEIDDDIDIKIEEKDIRVDVYRSSGAGGQHVNTTDSAVRITHMPSGIVVACQNERSQIKNRDTAFKMLKARLYELEQEKAKEELEKKSGEKKDITWGSQIRSYVFHPYNLVKDHRTDHETGNVAAVMDGDIEPFILAYLKTL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPP2_HUMAN
Sequence: MGSLFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERILVYLVQEINRADIPLPEGEASPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRKNLLELIEYTHMLRVTKTFVKRNVEFEPTYEEFPSLESDSLLDYSCMQRLGAKLGFVSGLINQGKVEAFEKMLWRVCKGYTIVSYAELDESLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHVYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVIQVKKMKAIYHMLNMCSFDVTNKCLIAEVWCPEADLQDLRRALEEGSRESGATIPSFMNIIPTKETPPTRIRTNKFTEGFQNIVDAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLNQSQEIMRMFFNGRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHPPAEHKKMVLWNDSVVRHNSILQLDPSIPGVFRGPYPLGIDPIWNLATNRLTFLNSFKMKMSVILGIIHMTFGVILGIFNHLHFRKKFNIYLVSIPELLFMLCIFGYLIFMIFYKWLVFSAETSRVAPSILIEFINMFLFPASKTSGLYTGQEYVQRVLLVVTALSVPVLFLGKPLFLLWLHNGRSCFGVNRSGYTLIRKDSEEEVSLLGSQDIEEGNHQVEDGCREMACEEFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFNNDDSVA
What is the function of this protein?
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  Essential component of the endosomal pH-sensing machinery (PubMed:16415858).  May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (PubMed:18157129).  In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).
What are the official names of this protein?
V-type proton ATPase 116 kDa subunit a 2, V-ATPase 116 kDa subunit a 2, Lysosomal H(+)-transporting ATPase V0 subunit a 2, TJ6, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase 116 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, also detected in subapical vesicles.
Protein: CTGE4_HUMAN
Sequence: MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF
What is the function of this protein?
Tumor-associated antigen.
What are the official names of this protein?
cTAGE family member 4, Protein cTAGE-4.
What is the protein family that this protein belongs to?
Belongs to the cTAGE family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL39_HALS3
Sequence: MGKKSKASKKRLAKLERQNSRVPAWVMMKTNRDVQRNPKRRNWRRNDTDE
What are the official names of this protein?
50S ribosomal protein L39e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: DAPE_NEIMB
Sequence: MTETQSLELAKELISRPSVTPDDRDCQKLLAERLHKIGFAAEELHFGDTKNIWLRRGTKAPVVCFAGHTDVVPTGPVEKWDSPPFEPAERDGRLYGRGAADMKTSIACFVTACERFVAKHPNHQGSIALLITSDEEGDALDGTTKVVDVLKARDELIDYCIVGEPTAVDKLGDMIKNGRRGSLSGNLTVKGKQGHIAYPHLAINPVHTFAPALLELTQEVWDEGNEYFPPTSFQISNINGGTGATNVIPGELNVKFNFRFSTESTEAGLKQRVHAILDKHGVQYDLQWSCSGQPFLTQAGKLTDVARAAIAETCGIEAELSTTGGTSDGRFIKAIAQELIELGPSNATIHQINENVRLNDIPKLSAVYEGILARLLAGNAV
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: T9797_TITSE
Sequence: AENRERVMVQ
What are the official names of this protein?
Peptide 9797, Peptide Ts20.
What are the subcellular locations of this protein?
Secreted.
Protein: COXX_BACC0
Sequence: MNHATSELHDESAVTSIPETTRLQDLKALVKMGIVNSNTLTVFTGFWLALHFNGLSVMDNLDKLFFTIVGSGLVMAGVCCLNNYIDRDIDPLMERTKTRPTVTGKYKPGFALTFGLVILLLGFVFLLLTTPMAVLMGFIGAFTYVVLYSLWTKRKYTLNTVVGSISGAVPPLIGWAAIDPSLGHPIAWMLFLIMFIWQIPHFLALAMKRVDEYRNAGIPMLPVVHGFEITKRQIMIWTVCLLPLPFYMSGLGITFMVIATLLNIGWIVLGFYGFRKKDDIKWSVQMFVYSLNYLTILFVSMIVVTFF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCSP_EDWI9
Sequence: MTQTLTQLENSDAFIARHIGPTPEEQQQMLAQIGAADLDTLLARIVPADIQLPAAPPIGAACSEQQALDELRAIAAQNQCYRSFIGMGYYGVQTPPAIQRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQMTLDLTGLDLASASLLDEATAAAEAMGLARRASRLKQANTFFIAQDVHPQTIDVVCTRAQSCGVEVIIDDARRAADHRDLFGVLLQQVGTQGDLHDYRALMDSLRERGVITCMAADPLALVLLEAPGRQGADVVFGSAQRFGVPMGYGGPHAAFFACREAFKRAMPGRIIGVARDAAGEPALRMAMQTREQHIRREKANSNICTSQVLLANIAGMYAVYHGPQGLRRIAERVHRLADILALGLQQKGVTLRNHCWFDTLTVAVPDKGAVLARALGFGINLRGDLDGAVGISFDECSTRDDLEALFTILLGDGHALDIDTLDTLVQEACEGSIPAALLRREPILTHPVFNRYHSETALMRYMHALERRDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAALHPFCPPEQAQGYRLLLSQLAEWLVQLTGYDAVCLQPNSGAQGEYAGLLAIRRYHESRGEGQRTRCLIPASAHGTNPASAQMAGMEVEVVACDEQGNIDLHDLRERARQAGERLAAIMVTYPSTHGVYEETIREVCQIVHQYGGQVYLDGANMNAQVGITTPGYIGADVSHLNLHKTFAIPHGGGGPGMGPIGVKAHLAPFVPGHRVVQLAGLTTRQGAVSAAPFGSASILPISWMYIRMMGAEGLRRASTVAILNANYIARRLGAVYPVLYRGKEGYVAHECILDLRPLKARSGISEMDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESENKAELDRFIAAMLAIHDEITRVETGEWPLQDNPLVNAPHTQRELVGEWHHPYGRELAVFPTPQTRENKYWPAVKRLDDVYGDRHLQCSCPPLSDWA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: MED14_ASPOR
Sequence: MPGVVMDNTNIGGAGQGSAIHDSRNGMPSLTPNINRNSAFGDSHVGRVHINGMTKNAVDPSQAEDASTVNIKSTKSMELPELPHITQGFFPFSKLISRSVQQSWNDLSDLITEMADIKVSPQEQNSLQLPASGKSFGNQSPENLRKKARILDFAHAKRAEFIKLLVLSQWSRQAADVSKLIDLQNFIRTRHQAYMGALQGIGDMKRDLVQAQVANPDLTTALEVLSKGKVSSMSDLGYKPPRSLTGKDTLKRLQKINRIISVRLALYDSVPRAFHSYSIHDGRVTFVVPNEFELDLSIGQEDESSQLYFVDIRFLFNPSSPNLKGRIFNEFDVKINDALRNNGLSGCFDLLHSLVLTNKINILFKQAMELARGLWYDVLRVELLHRTLVVHYWTQKAGAKSWLEIGIKSGRICGENDSYRHPNLGLRWIRDGQEVDSEEIEFNTKSLSMESILRSVIALHISHILSSAYCIISESLLYSAGRLSLQAQLTRTEPGDCGLTIQLTESRHLSVSIEPMSGASIISATPSAQERLDNDRSSDKSSAEDIAARVARLRCMAAIDEIESNVKMLGFETVNPRSLKIDFRRLFPNNVLRFSFFWHHLWERNWIVAATSSMDGDNWWVVQLQTTTTAESHSVFDASTHISSTLRSAQAISGSFFHVNQNIGYPSFADLGHYLSGILAVHTNARYLADLQTVDFYPPLQRLVIEPNLQVPEIFMRYEAANIPEVFRIALPSGLKSRVRTKGTIRLAFHGVDPCKKVATIVAYGNLLIPIKAFSALNSTRDHSLVFQKRGTGFAIRLLAPPGRPVIPKLMENLQRLDCILSIFECLQRKKMETRSLSLSHVTFAYGPEKDLLATLKIETSMPSSSMELDPIFLASRTKSLFHLRLGLSFEFPNPHRRIQKSIESTLNHSTTDAGLDTVAELLLLTLPLMRALDQILMNPSNRQPLRVQVTVRNAKTFQIHYPGQSFRFQLVATHHLSHMVWILKELSSPKERSSQDQLKLRLRERLYNSKGDGWRGLGNGVVAETGKVGNLLTELDRCFEASSTPGLTPEVKASGSKSFSQQLTAENGNVEGTLSESATLIPTPNATSTRHKTGDTTQNADIIMID
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVC_STRCO
Sequence: MRVLGVDPGLTRRGIGVVEGVAGRPLTMIGVGVVRTPADADLGHRLVAVEQGIEQWLDEHRPEFVAVERVFSQHNVRTVMGTAQASAVAILCASRRGIPVALHTPSEVKAAVTGSGRADKAQVGAMVTRLLRLAAPPKPADAADALALAICHIWRAPAQNRLQQAVALHTAQGPRRPHKLHPSKGRPA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: SEQA_VIBA3
Sequence: MKTIEVDEDLYRFIAGQTERIGESASDILRRLLLVDNQGTVPIEEIVEPKGIVVSKEVGFTPEKFDGVKEMRSLLISDEFASLKKAIDRFMLVLSTLHKIDPLSFSEATQVKGRKRVYFADNEATLLANGNTTKPKAIPQSPFWVITNNNTSRKRQMVEQLMSRMNFQAELIEKVTGSI
What is the function of this protein?
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle.  Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins.  Repression is relieved when the region becomes fully methylated.
What are the official names of this protein?
Negative modulator of initiation of replication.
What is the protein family that this protein belongs to?
Belongs to the SeqA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END4_ECO7I
Sequence: MKYIGAHVSAAGGLANAAIRAAEIDATAFALFTKNQRQWRAAPLTTQTIDEFKAACEKYHYTSAQILPHDSYLINLGHPVAEALEKSRDAFIDEMQRCEQLGLSLLNFHPGSHLMQISEEDCLARIAESINIALDKTQGVTAVIENTAGQGSNLGFKFEHLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLRTPAECEKTFADFARIVGFKYLRGMHLNDAKSTFGSRVDRHHSLGEGNIGHDAFRWIMQDDRFDGIPLILETINPDIWAEEIAWLKAQQTEKAVA
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: ROMO1_XENTR
Sequence: MPVAVGPYGQSQPSCFDRVKMGFMMGFAVGMAAGALFGTFSCLRFGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC
What is the function of this protein?
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation.  May play a role in inducing oxidative DNA damage and replicative senescence.  May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).
What are the official names of this protein?
Reactive oxygen species modulator 1, ROS modulator 1, Protein MGR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the MGR2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RL36_BACC1
Sequence: MKVRPSVKPICEKCKVIRRRGKVMVICENPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LTAS_STAAW
Sequence: MSSQKKKISLFAFFLLTVITITLKTYFSYYVDFSLGVKGLVQNLILLMNPYSLVALVLSVFLFFKGKKAFWFMFIGGFLLTFLLYANVVYFRFFSDFLTFSTLNQVGNVESMGGAVSASFKWYDFVYFIDTLVYLFILIFKTKWLDTKAFSKKFVPVVMAASVALFFLNLAFAETDRPELLTRTFDHKYLVKYLGPYNFTVYDGVKTIENNQQKALASEDDLTKVLNYTKQRQTEPNPEYYGVAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSSGKEQFTYFPNFFHQTGQGKTSDSEFTMDNSLYGLPQGSAFSLKGDNTYQSLPAILDQKQGYKSDVMHGDYKTFWNRDQVYKHFGIDKFYDATYYDMSDKNVVNLGLKDKIFFKDSANYQAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLNRTGFWIKIPGKSGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDLFSKGHNQVVPFRNGDFITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFKKVNPSKYKYETGPKANSKK
What is the function of this protein?
Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate.  Is required for staphylococcal growth and cell division process (By similarity).
What are the official names of this protein?
Lipoteichoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the LTA synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Processed glycerol phosphate lipoteichoic acid synthase]: Secreted.
Protein: VG63_ICHVA
Sequence: MYVVVSVEPLLAWCVVADARDDAVIKHAIRGWICATVDLQPVTLGAVFFTRIPSVGSRLVENSDFHWIVKLPIDGAQQIDTVDRWIALAGCTGGGEANVPSLLENMLFLGFEPEKTATWSAIYTMESAIYNHLLRKGVDIAFHHIIFRRFCDQLDHLGPVPIDVFEKWIPDALLNLEREYGLSIYNLDDKRNFTKFSRPRLGKVLLKRWLADNMIKTNEVSDAELLAICDPDVTPAEPATGAMDLSSLEELIMTLNSRVNIPKAGSFHRVTLRRVTFHQLIKYCLNDDPDDLSVVSLPPRNALPHVPILLMDDSMSHEGVFQYVITDYKSMETVPPGAYSEVFLEGQIVTVLNFDIDRKFSGLLDPMGAIDNICEIFVAFLHRAVEKFFNFNRVDKNRIGEVAVFVRRAALPGKFSARFTWFPAYELCFQNIREAADFTGVFQELLMEEDSFFVYTVTNDGVSTRVCAIDAQPFCRNKSCRLPNSTKMEAGEFRGAFEYIKSYNALVKSNRGYSKMNIGISRSPVAFDRPSLGPQYIFGALARFASAEVTYNSSHASENITVEKDHIDNAYKLLSTIWGDLKISPTTSGSVRLTPWMTRDRFCLVHNRIHHKAGVSVIVTNRRIYPKCFHPDPPAHVIPEGGFLDVVEVAGKPRARVGFCGQ
What are the official names of this protein?
Uncharacterized protein ORF63.
Protein: RUVA_BORBZ
Sequence: MINKIHGKVIEKKESSLVLMTTVFEFELLVSAFCLANFNLSDKVELFTYLYTRENELKLFGFLNSDEREIFKELIGVSGVGPRAALRVLSNIRYNEFKEAIDKEDIELVSKIKGIGKKMAGKMFLHLQGKLLINSELESTGLFRFKELEESIVSMGFDRKIVNSKIREAFNLAEFANLKDSEKEQFLFKEVLKRISN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.