PharMolix/UniProtQA huggingface dataset:
Protein: SYW_SULAC
Sequence: MAQDFTVTPWEVKGKVDYDKLIVQFGTQKMTSELKERAKRAINDELHVMLRRDVFFSHRDFDLILNDYEKGNGFFLYTGRAPSLGMHIGHLIPFIFTKWLQEKFKVNVYIEITDDEKFLRNVDYTLDQTKEWSYENILDIIAVGFDPNKTFIFQDTEYIKNMYPLSVKIAKKLTFNEVRATFGLDTSSNIGIIFYPALQIVPTMFEKRRCLIPAGIDQDPYWRLQRDIAESLGYFKAAQIHSKFLPPLTGPEGKMSSSQPETAIYLTDDPKTVERKIMKYAFSGGQATVELHRKYGGNPDIDVAFQWLYMFFEPDDQRIRKIEEDYRSGAMLTGELKQILVDKLNAFLEEHREKREKAKDLVNVFKFDGDLARDMWKRIHV
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB1_BURP0
Sequence: MSTAALVEGKIVQCIGAVIDVEFPRESMPKIYDALILEGSELTLEVQQQLGDGVVRTICLGASDGLRRGVVVKNTGNPISVPVGKPTLGRIMDVLGRPIDEAGPIESENKRSIHQKAPAFDELSPSTELLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELINNIAKEHGGYSVFAGVGERTREGNDFYHEMKDSNVLDKVALVYGQMNEPPGNRLRVALTGLTMAEHFRDEGLDVLFFVDNIYRFTLAGTEVSALLGRMPSAVGYQPTLAEEMGKLQERITSTKKGSITSVQAVYVPADDLTDPSPATTFGHLDATVVLSRDIASLGIYPAVDPLDSTSRQIDPNVIGEEHYSITRRVQQTLQRYKELRDIIAILGMDELSPEDKLSVARARKIQRFLSQPFHVAEVFTGSPGKYVPLKETIRGFKMIVDGECDHLPEQAFYMVGTIDEAFEKAKKIQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 1, ATP synthase F1 sector subunit beta 1, F-ATPase subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KCAB2_RAT
Sequence: MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS
What is the function of this protein?
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:9763623, PubMed:21357749).  Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity).  Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (PubMed:10896669, PubMed:16770729, PubMed:18003609, PubMed:21357749).  Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:21357749).  Modulates the functional properties of KCNA4 (PubMed:9763623).  Modulates the functional properties of KCNA5 (By similarity).  Enhances KCNB2 channel activity (By similarity).  Binds NADPH and has NADPH-dependent aldoketoreductase activity (PubMed:18672894, PubMed:21209188).  Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (PubMed:18672894).
What are the official names of this protein?
Voltage-gated potassium channel subunit beta-2, K(+) channel subunit beta-2, Kv-beta-2.
What is the protein family that this protein belongs to?
Belongs to the shaker potassium channel beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated (PubMed:21357749).
Protein: PUR7_PSEPG
Sequence: MEKRDELYRGKAKSVFKTDDADRLILLFRNDTSAFDGKRIEQLDRKGMVNNKFNAFIMQKLEEAGVPTQFDKLLGDNECLVKKLDMIPVECVVRNYAAGSLVKRLGVEEGIKLEPSTFELFLKNDEKGDPFINESHVVAFGWGTAEQLVEMKKLSLKVNEVLSKLFDDAGLLLVDFKLEFGVFHGQIVLGDEFSPDGCRLWDKETRKKMDKDRFRQGLGDVIEAYEEVAKRLGVPL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RL28_PSYCK
Sequence: MSRVCQVTGKRPMVGNNVSHANNKTRRRFLPNLHNHRFWVESENRFVRLRVSTKGMRIIDKLGIDKVLVDLRAQGQKV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SYL_EHRRG
Sequence: MHYDFKEVERDVQEKWDFTVNVKDVQCYVLEMFPYPSGNIHMGHLRNYTIGDVIARYKRACGLHVFHPIGWDAFGLPAENAALSYNISPQVWTRKNIDNMRSQLKSIGLSYNWDKEFATCDAEYYKYEQEFFLDFLKYGLAYRKESLVNWDPVDQTVLANEQVIDGRGWRSGAIIEKRKLSQWFLKITDFAAELLDDLKSLNQWPEKVKLMQERWIGKSEGVIIDFQIVGINEVLQVFTTSPHTLFGASFIAVSFDHPILKYVNDVQLIQLIDSFDRKDLIDDSSINTVEKFGINSGLVAKHPLLDMDLPIYVANFVLMNYGTGAVFCCPAHDQRDFDFAKKYSLPIRQVIFPEQNVDLEREAYVGSGIMGCSGFLDGMTVDDAKKSMIEKLISLGICKKQVYYRLHDWGISRQRYWGCPIPIIYCKKCGIVPVDKKDLPITLPEDIDFTKSGNPLDNHPTWKYTKCPSCGADAKRETDTFDTFFESSWYFAAFCGIGKGIDKDVCNKLLPVDYYIGGIEHAVLHLLYSRFFCRALTRCGYFDVKEPFSSLITQGMVCHSTYLDKYGNYLFPEDGKKMIQEGKYVTVGRAEKMSKSKKNVVHLDDIIDKYGADSARLFILSDTPPERDIEWLDENIEGVSRYLNKLWKMIVDYDQIEQNFVFNDISNDAVEYRMNVHKILNDITNDLEFYRFNCAVAKFRELSNVISEMIRLSINHHVVSEAIYILIRVVEPFIPHIAEKLWQIVGGQGMLCNQLWPKVDSQLLIKKNVNIVVQVNGKFIKAVSVPNDIDDDTLKSIALEVAQRRIGNSSVKNIYIIPARVINIVITKSS
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_BORAP
Sequence: MTKNVKKNIKDEINIIVTNLALSKNIKLDEININIQKPPKSDLGDISILIFELSKTLKLPIETISEEIIKALKAKYEIKAMGPYLNIKIPRKEYIHNTIQMVNAQKDTYGTSKYLDNKKIILEFSSPNTNKPLHVGHLRNDVIGESLSRILKAVGAKIIKLNLINDRGVHICKSMLAYKKFGNEITPEKAFKKGDHFIGDFYVQYNKYAQENENAEEEIQDLLLKWEQKDASTIELWKKLNNWAIEGIKETYKITNTSFDKIYLESEIFEIGKNVVLEGLEKGFCYKREDGAICIDLPLDSDEKTDTKVKQKVLIRSNGTSIYLTQDLGNIAVRIKEFNFEEMIYVVGSEQIQHFKNLFFVSEKLGISKNKKLFHLSHGMVNLVDGKMKSREGNVIDGDNLILDLMESILPEITQKIENKENAKKNALDIALGAIHYYLLKSAIHKDIVFNKKESLSFTGNSGPYIQYVGARINSILEKYNTLSIPIIKKINFELLEHEKEWDIIKIISELEENIIKAAKDLNPSILTSYSYSLAKHFSAYYQEVRVIDINNIDLTAARIEFLKAILQTIKNCMYLLNIPYMLKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_PROM2
Sequence: MNKRKILVPLGEKSYEVTLEAGILNNISEELLKIGITKKRKILVISNEEISNLYGKKFLNNLKDNKFQAKMFLIKAGESYKNLKTLSEIYDVAFEFGLDRNSIIIALGGGIVGDVSGFAAATWLRGIEYIQIPTTLLSMVDSSVGGKTGVNHPKGKNLIGAFNQPKAVFIDPETLKSLPKREFSAGMAEVIKYGVIRDKELFEYLEIDKNKNELINLKNEYLIKIINSSIKTKSHVVSQDEHENGVRAILNYGHSFGHVIENLCGYGKFLHGEAISIGMNIAGKIAIEKGLWSKEELERQRVLLESYDLPTEIPKINKEDVLTILMGDKKVRDGKMRFILPKEIGAVDIYDDVEDSLFLKFFS
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPPH_STRMK
Sequence: MIDPDGYRPNVGIVLMRQDGQVFWARRVRRDGWQFPQGGMNTDETPVEAMYRELQEETGLLPEHVEVLGATPGWLRYKLPARAIRRNERQVCIGQKQVWFLLRLTGDESHVKLDHTDSPEFDHWRWVDFWYPVEHVVMFKRGVYARALRHLAPLARGVAGQGVTAMPKSAAEAWMPGHTAGHDRPRKRPRTRGYWPKKATGDGPAS
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: CP2H1_CHICK
Sequence: MDFLGLPTILLLVCISCLLIAAWRSTSQRGKEPPGPTPIPIIGNVFQLNPWDLMGSFKELSKKYGPIFTIHLGPKKIVVLYGYDIVKEALIDNGEAFSGRGILPLIEKLFKGTGIVTSNGETWRQLRRFALTTLRDFGMGKKGIEERIQEEAHFLVERIRKTHEEPFNPGKFLIHAVANIICSIVFGDRFDYEDKKFLDLIEMLEENNKYQNRIQTLLYNFFPTILDSLPGPHKTLIKNTETVDDFIKEIVIAHQESFDASCPRDFIDAFINKMEQEKENSYFTVESLTRTTLDLFLAGTGTTSTTLRYGLLILLKHPEIEEKMHKEIDRVVGRDRSPCMADRSQLPYTDAVIHEIQRFIDFLPLNVPHAVIKDTKLRDYFIPKDTMIFPLLSPILQDCKEFPNPEKFDPGHFLNANGTFRRSDYFMPFSAGKRICAGEGLARMEIFLFLTSILQNFSLKPVKDRKDIDISPIITSLANMPRPYEVSFIPR
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 2H1, CYPIIH1, Cytochrome P450 PB15, Cytochrome P450 PCHP3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: CCD92_MOUSE
Sequence: MAATNLENQLHSAQKNLLFLQREHASTLKGLHAEIRRLQQHCTDLTYELTLKSFELTGDSSSRTTELKRRCEELEAQLKAKEEENRKLLQELEQKNAAIAVLENTVREREKKYLEELKVKSHKLSMLSGELEQRASTVAYLTSQLHAAKKKLLSSSGTSDASPAGSPALASYKPTPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAMPDPTPFLLARESAEVQLKERPLVIPPIASDRSATGQHSPARDKPHKTHVGVAHRIHHATPSQAQPEGEMRAVDQVNASKVVRKHSGTDRTV
What is the function of this protein?
Interferon-stimulated protein that plays a role in innate immunity.
What are the official names of this protein?
Coiled-coil domain-containing protein 92.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm.
Protein: TSAD_CALS4
Sequence: MAKDIVILGIETSCDETAAGVVKNGKEVLSNVIYSQINVHKKYGGVVPEIASRKHIEAISFVVEEALNEAKLSLDEVDAIAATYGPGLVGPLLVGLSYGKALAYAKGKPFIGVNHIDGHIAANYIGGNLTPPFVCLVASGGHSHIVYVKDYGEYEVMGKTLDDAAGEAFDKVARALGLGYPGGPAIEKAAKLGNMEAIEFPKSFMEEGNFDFSFSGVKTAVLNYLNRQKQKGEEVNIYDVAASFQRNIVEVLVKKLVEAARFKNVSKVSIAGGVASNGFLRQKLEEDAKKFGLSVYYPEKIYCTDNGAMIAAAAYYDFVKGKFSGMDLNAIPYLKIGESDC
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PENG_PENCR
Sequence: MLFLAPGYIFPNVATPVTVAIDFAQAVKQGAYNVLDLKASPIPNPELFQPPSRIIRGPLNYLLSLPGKDIRGKLIDALNEWFRVPEDKLNIIKEIVVILHTASLLIDDIQDSSELRRGNPVAHRIFGVAQTINSANYAYFLAQAKLADLNDSRAFDIFTKGLLKLHRGQGMELYWRDNLICPTEEEYVEMVSCKTGGLFYLAVQLMQLNSEVTVNFSNFINLLGIIFQIRDDYMNLQSGTMTKTKGFSEDLTEGKFGYPIIHSIHAAPNDSQLIQILKLKTKDEVIKQYAVRYIESTGSFVYCREKLDMYLEEANETFRGLEMLLGPSKGIRAILDFLRTR
What is the function of this protein?
Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:26213965).  The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (Probable).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase penC then forms 3-geranylgeranylindole (3-GGI) (Probable).  Epoxidation by the FAD-dependent monooxygenase penM leads to a epoxidized-GGI that is substrate of the terpene cyclase penB for cyclization to yield paspaline (Probable).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase penP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase penQ (PubMed:26213965).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase PC-15 which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase penD (Probable).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase PC-16 and the P. simplicissimum ptmI-ortholog not yet identified in P. crustosum, leads to the production of the prenylated form of penijanthine (Probable).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase PC-22 (Probable).  A series of oxidation steps involving 4 cytochrome P450 monooxygenases (PC-21, PC-05, PC-23, PC-20) and a FAD-dependent monooxygenase (PC-14) are required for the transformation of PC-M4 to penitrems A and E.  Synthesis of these final products is proposed to proceed via penitrems D and C (PC-21, PC-05, PC-14) and penitrems B and F (PC-21, PC-05, PC-14, PC-23) (Probable).
What are the official names of this protein?
Geranylgeranyl pyrophosphate synthase penG, GGPP synthase, GGPPSase, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase, Penitrem biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: CYSD_YEAST
Sequence: MPSHFDTVQLHAGQENPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP
What is the function of this protein?
Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (PubMed:7765825, PubMed:4609980, PubMed:795806, PubMed:36455053, PubMed:36379252).  Required to efficiently reduce toxic levels of hydrogen sulfide generated when the sulfate assimilation pathway (SAP) is active (PubMed:36455053, PubMed:36379252).  Also catalyzes the conversion of O-acetylserine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway (PubMed:7765825, PubMed:4609980, PubMed:795806, PubMed:36455053).  However, it seems that in S. cerevisiae cysteine biosynthesis occurs exclusively through the cystathionine pathway and not via direct incorporation of sulfur into OAS (PubMed:1732168).  It therefore has no metabolic role in cysteine biosynthesis and may only have a regulatory role controlling OAS levels (PubMed:12586406).
What are the official names of this protein?
Homocysteine/cysteine synthase, O-acetylserine/O-acetylhomoserine sulfhydrylase, OAS-OAH SHLase, OAS-OAH sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALG12_ARATH
Sequence: MPTDSKMAKFLQSYGYDLILGSVAAIYVVMAPYTKVEESFNVQSMHDILYHRHHLDSYDHLEFPGVVPRTFIGAFIVSVFASPVVSIISCLGFPKVYSLVAARLVLGCIILSTLRFFRIQIKKKFGNQVETFFVLFTSLQFHFLFYCTRPLPNILALGLVNLAYGNWLKGNFYPALSFLIFATVIFRCDTMLLLGPIGLELLLTKSISFWKALKYCVGTALLAVGLTIFVDSIMWKKFVWPEFEVFWFNSILNRSSDWGTHSIHWYFTSALPRSLLVAYPLSLLGTLVDRRVPFFIVPVLSFVILYSKLPHKELRFIISSVPMFNLSAAVAASRIYNNRKKTIWKLVNMVMLAFFAISAGCTVVTFMASYYNYPSGYALKRLHQIGHPANVAGEEWVHIDTFGAMNGISRFCEDDFPWRYSKEEEIVVEELRNRNFTYLVNEHSSVDGYKCLFYEEGFERLELRRGFPPIVLVKKAKVYLHREMKKEDPFHKKWPGC
What is the function of this protein?
Required for N-linked oligosaccharide assembly.  Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor dolichol-PP-Man(7)GlcNAc(2).
What are the official names of this protein?
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase, Alpha-1,6-mannosyltransferase ALG12, Asparagine-linked glycosylation protein 12, EMS-mutagenized BRI1 suppressor 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MAO1_SHESM
Sequence: MDDNKRPLYLPFAGPAILEAPLINKGSAFSEEERIFFNLEGLVPYAIETIEEQASRAYDQFRSFNNDLDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGLACERFSKNYRRNRGLFISYPNKDRIDDILNNSTRQKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPQLLEDPMYMGWRHPRIGGEEYAEFIEAFMQAVHVRWPDTLIQFEDFAQKNAMPILERYKERYCCFNDDIQGTAAVTVGSLLAACKAAGTELNKQRVAFLGAGSAGCGIAEAIVAQMVSEGISDEQARSQVCMVDRWGLLLDNMPNLLPFQQKLAQKCADISHWNNFSDNISLLDVVNNVKPTVLIGVSGAPGLFTEEIVRAMHSHCERPIIFPLSNPTSRVEATPKDILHWTSGQALVATGSPFEPVVVDGETYEIAQCNNSFIFPGIGLGVLASGARHVSDAMLMASSRALAECSPLAINGSGPLLPKLEDIHSVSKHIAFAVGKVAIEQGLSLPASDELLMQSIEDNFWKPEYRRYKRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: SYEC_NOSCE
Sequence: MAVENAINFREICSLLDISESYKCTINAFLDNVEKCTDKHYNDALNLLDTFFSNEVKSNSLVNDLIFCIINSNFDFLKVFKSNKLRLENLQIVYESAFNENKPFLKEFSAKDKINKEVKKNLYSTPAVTRFAPEPSGCLHIGHLKALLVNYNLAEKSNGTLLLRFDDTNPVKNYEKYEKEILRDLDTLGITGLKISHSSDYFELLVDEAVSLINKNLAYVDNTDQETMRIERFEGIESKMRNINNSESLKIFKELLQGRAPGYCLRAKIDMSNPNKSMRDPVIYRASDKMHGRCKLYKAFPTYDFVCPIVDSIEGVTVVCRANEYKDRNEQYKWFLENLELENKPEFNDFSKLNLEDTVLSKRKIDKLISDSLVTGWDDPRLATIQGIKRLGMHMTALKDYINLQGASNKTNVISWDKIWAMNKKVIDPLSPRFMAVEKINCVRVFITNFEGLKYTKNIPLNKKNTSLGSKDVLFSDTLLFSQEDGFVLKENEEFTLMNWGNAIVEKKVVENSIVTELYIKLHLEGDYKSTTNKISWVSESGAVTATGIEYGKLLVNEEFNINSKIDKQYYVESSITNLSTDMKHVQFERIGFFYCDSPCVFHLVPFTKQKRTY
What are the official names of this protein?
Probable glutamate--tRNA ligase, cytoplasmic, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_SHESR
Sequence: MSKKLHIKTWGCQMNEYDSSKMADLLGEYQGYTLTEEAEEADILLLNTCSIREKAQEKVFHQLGRWKTLKDKNPDLIIGVGGCVASQEGKAIKDRAHCVDIIFGPQTLHRLPDMIEQVRRGEKAVIDVSFPEIEKFDRLPEPRAEGPTAFVSIMEGCSKYCSFCVVPYTRGEEVSRPSDDIILEIAQLAEQGVREVNLLGQNVNAYRGATHDGGICTFAELLRYVAAIDGIDRIRFTTSHPIEFTQDIIDVYEDTPELVSFLHLPVQSGSDRILTAMKRGHMAIEYKSIIRRLRKARPDIQISSDFIIGFPGETKEDFADTMKLIEDVAFDHSFSFIYSARPGTPAADLPDDVDMEEKKQRLAILQDRITQQAMRYSRHMMGTVQRILVEGPSVKNPMELRGRTENNRVVNFEGQPKHIGSFVDVEIVDVYTNSLRGKFIRGEDEMDLRRNLRPSDILAKHKQDDDLGVTQFKP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1848_CAMC1
Sequence: MFEGFDFSKMGQMLEDVQKQAKQMEEESKNKEFGAKSGGGLVSVRANGSGEILDISIDDSLLEDKESMQILLISAINDVLKSVEADKKNTASRMLGGLASMGIK
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Ccon26_18480.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL31_BARHE
Sequence: MKANIHPDYHKITVVMTDGSQYTTRSTWGKEGDVLNLDIDPRTHPAWTGGSQTLVDHGGRISKFKNRFGNLGM
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: STT3B_HUMAN
Sequence: MAEPSAPESKHKSSLNSSPWSGLMALGNSRHGHHGPGAQCAHKAAGGAAPPKPAPAGLSGGLSQPAGWQSLLSFTILFLAWLAGFSSRLFAVIRFESIIHEFDPWFNYRSTHHLASHGFYEFLNWFDERAWYPLGRIVGGTVYPGLMITAGLIHWILNTLNITVHIRDVCVFLAPTFSGLTSISTFLLTRELWNQGAGLLAACFIAIVPGYISRSVAGSFDNEGIAIFALQFTYYLWVKSVKTGSVFWTMCCCLSYFYMVSAWGGYVFIINLIPLHVFVLLLMQRYSKRVYIAYSTFYIVGLILSMQIPFVGFQPIRTSEHMAAAGVFALLQAYAFLQYLRDRLTKQEFQTLFFLGVSLAAGAVFLSVIYLTYTGYIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHILVCTFPAGLWFCIKNINDERVFVALYAISAVYFAGVMVRLMLTLTPVVCMLSAIAFSNVFEHYLGDDMKRENPPVEDSSDEDDKRNQGNLYDKAGKVRKHATEQEKTEEGLGPNIKSIVTMLMLMLLMMFAVHCTWVTSNAYSSPSVVLASYNHDGTRNILDDFREAYFWLRQNTDEHARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSNETAAYKIMRTLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIRESDYFTPQGEFRVDKAGSPTLLNCLMYKMSYYRFGEMQLDFRTPPGFDRTRNAEIGNKDIKFKHLEEAFTSEHWLVRIYKVKAPDNRETLDHKPRVTNIFPKQKYLSKKTTKRKRGYIKNKLVFKKGKKISKKTV
What is the function of this protein?
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667).  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.  This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity).  STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A.  STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins.  Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation.  Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation (PubMed:19167329, PubMed:22607976).
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B, Oligosaccharyl transferase subunit STT3B, STT3-B, Source of immunodominant MHC-associated peptides homolog.
What is the protein family that this protein belongs to?
Belongs to the STT3 family.