PharMolix/UniProtQA huggingface dataset:
Protein: EFTS_PROM4
Sequence: MPDITAKLVKELRDKTGAGMMDCKKALVESDADMEKAVEWLRQKGISSAEKKSGRVAAEGAIGSYIHTGSRVGVLLELNCETDFVARGELFQGLLRDISMQIAACPNVEFVAVDDIPVEVSDKEKSIEMGRDDLSGKPDQIKEKIVAGRISKRLKELALIEQPFIRDTSITVEQLVKQVAGQIGENLRIRRFTRYTLGEGIETDQSDFAAEVASISSK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBPZ_SIMVI
Sequence: QYHTLPEIYSWLDRLVQEHPEHVEPVVGGKSYEGREIRGVKVSYKKGNPVVMVESNIHAREWITAATTTYLLNELLTSKNSTIREMAENYDWYIFPVTNPDGYVYTHTTDRMWRKTRSPNPDSLCAGTDPNRNWNFHWMEQGTSSRPCTETYGGKKAFSEVETRSFSDFLKTLKGQIKVYLAFHSYSQLLLFPYGHTCQHTYNHDDLQAIGDAAARSLAQRYGTDYTVGNIYDAIYPASGGSMDWAYDTLDIPIAYTYELRPRDGWNGFQLPANQIIPTGEETVDSVVTILKESRRLGYFNTSD
What is the function of this protein?
Involved in the digestion of the blood meal.
What are the official names of this protein?
Zinc carboxypeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FMT_HAEDU
Sequence: MSKLNIIFAGTPEFAAQHLQALLASQHNIVAVYTQPDKPAGRGKKLQASPVKQLALQHNIPVYQPKSLRNPQAQAELNALNGDVMVVVAYGLILPEAVLHIPRYGCLNVHGSLLPRWRGAAPIQRAIWAGDQETGVTIMQMDAGLDTGDMLHKVSTKIEADETSASLYMKLAKLAPPALLAVLDGLTEQQFKPEKQDNQLANYAEKLSKQEAKLDWNLPAYQLAQNIRAFNPWPMSFLTVEVEGVEQHVKVYQATVLAHQYHAVGTVLQVDKNGIQIATSEGVLNITQLQPQGKKPMSVQDFLNGRANWFSLGKKL
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: ILVD_SYNY3
Sequence: MSNNPRSQVITQGTQRSPNRAMLRAVGFGDDDFTKPIVGIANGYSTITPCNMGINDLALRAEAGLRTAGAMPQLFGTITISDGISMGTEGMKYSLVSREVIADSIETVCNGQRMDGVLAIGGCDKNMPGAMIAMARLNIPSIFVYGGTIKPGHYAGEDLTVVSAFEAVGQYSAGKIDEETLYGIERNACPGAGSCGGMFTANTMSSAFEAMGMSLPYSSTMAAVDGEKADSTEESAKVLVEAIKKQILPSQILTRKAFENAIAVIMAVGGSTNAVLHLLAIANTIGVPLSLDDFETIRHKVPVLCDLKPSGKYVTTNLHAAGGIPQVMKILLVNGILHGDALTITGQTIAEVLADIPDQPPAGQDVIHSWDDPVYQEGHLAVLKGNLATEGSVAKISGVKKPVITGPAKVFESEEDCLEAILAGKIQAGDVVVVRYEGPKGGPGMREMLAPTSAIIGAGLGDSVGLITDGRFSGGTYGLVVGHVAPEAYVGGAIALVQEGDQITIDAGKRLLQLNISEEELAQRRAQWTPPQPRYPRGILAKYAKLVSSSSLGAVTDIDLF
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SYFA_STRP2
Sequence: MSTIEEQLKALREETLTSLKQITAGNEKEMQDLRVSVLGKKGSLTEILKGMKDVSAEMRPIIGKHVNEARDVLTAAFEETAKLLEEKKVAAQLASESIDVTLPGRPVATGHRHVLTQTSEEIEDIFIGMGYQVVDGFEVEQDYYNFERMNLPKDHPARDMQDTFYITEEILLRTHTSPVQARAMDAHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKNISMADLQGTLQLIVQKMFGEERQIRLRPSYFPFTEPSVEVDVSCFKCGGEGCNVCKKTGWIEIMGAGMVHPRVLEMSGIDATVYSGFAFGLGQERVAMLRYGINDIRGFYQGDVRFSEQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UTER_RAT
Sequence: MKIAITITVLMLSICCSSASSDICPGFLQVLEALLLGSESNYEAALKPFNPASDLQNAGTQLKRLVDTLPQETRINIVKLTEKILTSPLCEQDLRV
What is the function of this protein?
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
What are the official names of this protein?
Uteroglobin, Club cell phospholipid-binding protein, CCPBP, Club cells 10 kDa secretory protein, CC10, PCB-binding protein, Secretoglobin family 1A member 1.
What is the protein family that this protein belongs to?
Belongs to the secretoglobin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GRPE_PSEA8
Sequence: MADEQQTLDQQTPEQPTGAAEDLTARVQELEEQLAAAQDQALRMVADLQNVRRRAEQDVEKAHKFALEKFAGDLLAVVDTLERGLEMSDPNDEAIKPMREGMELTLKMFDDTLRRYQVEALNPEGEPFNPEQYQAMAMQESASAEPGSVLKVFQKGYLLNGRLLRPAMVVVSKAPAETPPSIDEQA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASPQ_PSES7
Sequence: KEVENQQKLANVVILATGGTIAGAGASAANSATYQAAKVGVDKLIAGVPELADLANVRGEQVMQIASESITNDDLLKLGKRVAELADSNDVDGIVITHGTDTLEETAYFLDLTLNTDKPIVVVGSMRPGTAMSADGMLNLYNAVAVASNKDSRGKGVLVTMNDEIQSGRDVSKSINIKTEAFKSAWGPLGMVVEGKSYWFRLPAKRHTVNSEFDIKQISSLPQVDIAYSYGNVTDTAYKALAQNGAKALIHAGTGNGSVSSRLTPALQTLRKTGTQIIRSSHVNQGGFVLRNAEQPDDKNDWVVAHDLNPEKARILVELAMVKTQDSKELQRIFWEY
What are the official names of this protein?
Glutaminase-asparaginase, L-ASNase/L-GLNase, L-asparagine/L-glutamine amidohydrolase, PGA.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HNRH1_RAT
Sequence: MMLGAEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSEEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIETGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDFQSNIA
What is the function of this protein?
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm.  Mediates pre-mRNA alternative splicing regulation.  Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.  Binds to the IR RNA.  Binds poly(RG) (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein H, hnRNP H, Ratsg1.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: SYS_CHLAB
Sequence: MLDIKLIRKAPEECETRLRKKDPLISLQPILDLDKEIRHLKTETEALQSQRKLLSNQIHKAKAQGEDVSSMMDNVERISQDLAKLEPLLEQKESTLQDMLVRLPNYPDEDVPVCPDKTGNQVIKQVGALPTFSFTPKHHVELNQKLQILDFKLPAKTSGSGWPAYKNQGVCLEWALLTYLLNKQREHGFQLWLPPLLVKHEILFGSGQIPKFDGQYYRVEDGEQSLYLIPTAEVVLNGFHSQEIFSEKDLPIYYAAFTPCFRREAGAAGAHERGLVRVHQFHKVEMFAFTTPDQADQAYEKMLAVVEDILTELQLPYRLSLLSTGDMSFTASKTIDAEVWLPGQQSYYEVSSISQCTDFQSRRSETRYKDNRGKMHFVHTLNGSGLATPRLFVAILENNQQEDGSVIIPEVLRPYLENQEVLLP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COG6_AJECN
Sequence: MARSCKILAKLPRVGTAISNLTNVCEEMRRHIVLATQETAPLFEEAAILMSQQQEVETKEKILDAFNNHFILSEDELSSLTSSAKPVDDLFFDALARMKQIHKDCEVLLGSENQRLGLDIMEQSSKNLNGAFQKLYKWIQKEFKSLNLEDPQISLSIRRALRVLAERPSLFHNCLDSFADAREYTLSDSFHTALTDVPSGQERDMAARPIEFSAHDPLRYVGDMLAWVHSAAVSEREALEALFIGDEGEIAKGIQAGVNNEPWSRVDGEEIVFDGPKALNDLVTRDLNGVTRSLRQRVELVLQGNEDSIVIYKIIGLLAFYENTFSKLLGRESGLVTSVASLQEFAFKHFQILMQDQLAVVSAEPANLTPPADLSTPQFLHDALDNLTSLMKAYDSSFAHEHANDSSGENKFSPIIREALDPFLELAKTSSNDISDPTSRAVFHVNCLLSTRDAISPYPFVCVTHLPQLTNTLKTLRTTLLEIQHEFLLNASGLHILLTALKPFTPPATATLEPTRSSYPPDLATISSLPEFQPQTLSSISQQLDDFLPSALVDVTENLKAIHSPVLVKSVTEEAVEAFCTDFEFVEGMILGADEARGKLVVHGDGEDVGAEEAGEGEGEEPQADNWRLRSLFPRTTGEIRVLLS
What is the function of this protein?
Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking.  COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 6, COG complex subunit 6, Component of oligomeric Golgi complex 6.
What is the protein family that this protein belongs to?
Belongs to the COG6 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: YEDE_ECOLI
Sequence: MSWQQFKHAWLIKFWAPIPAVIAAGILSTYYFGITGTFWAVTGEFTRWGGQLLQLFGVHAEEWGYFKIIHLEGSPLTRIDGMMILGMFGGCFAAALWANNVKLRMPRSRIRIMQAIIGGIIAGFGARLAMGCNLAAFFTGIPQFSLHAWFFAIATAIGSWFGARFTLLPIFRIPVKMQKVSAASPLTQKPDQARRRFRLGMLVFFGMLGWALLTAMNQPKLGLAMLFGVGFGLLIERAQICFTSAFRDMWITGRTHMAKAIIIGMAVSAIGIFSYVQLGVEPKIMWAGPNAVIGGLLFGFGIVLAGGCETGWMYRAVEGQVHYWWVGLGNVIGSTILAYYWDDFAPALATDWDKINLLKTFGPMGGLLVTYLLLFAALMLIIGWEKRFFRRAAPQTAKEIA
What are the official names of this protein?
UPF0394 inner membrane protein YedE.
What is the protein family that this protein belongs to?
Belongs to the UPF0394 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRM1_DROME
Sequence: MEVDEEKPQIIAENPNENVIRERNAEIVSGGNVFYNPVQEFNRDLSIAALNVYRQRLTKERSEKALKKQRKKVKEQEDEKTTPVPEDPPVYEAGTRYEDGLRILEALAATGLRSIRYAQEIAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYGCPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIESHANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNPTAGNPQQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQRRIVGVLSMVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNAPPAVLWDILRSWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQENPTPHWGPGTRATIMIGDNKLPKSYRNQNKKQRHKASEQQAEDDQQDTPQAVDEYDGDVEHLPKQPKLEATA
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: YIDC_JANSC
Sequence: MDDQNRNLILATGLSFVVILVWFLLFPPPEMVEDPNAIPPAAETGGVETDTGIALTPPVTVADAPAGADTTAPSEVALSEAARIDIDTPAVEGSISLLGGRIDDLSLRNYFTEVDGDQIVRLLSPVGSDDPYYALYGWTPSGDLGYADVPTSDTPWELESGTILTPDSPITLAWDNGSGLIFRRTIEIDDRFMFQVTQSVENTGGAEVNLAPYGIVARHGLPSDLQNFFILHEGVVRKVDGELSELGYSDLPDLDIIAREGVPAEVMEVETNGWIGFTDKYWMTTLIPGENQSFVSVVKYVPSAEIYQTEARLPYMSIAPGETAEVTTQLFAGAKEAEAIRDYENAEPGLIASLFGAEQDASRGEIPRFIDSIDWGWFYFLTKPLFWLLHWLNGAIGNMGLAIISLTLIVKAVLFPLAYRSYVSMAKMKELQPEIEKLKESAGDDRQKLQQGMMELYKKNKVNPAGGCLPILLQIPIFFSLYKVIFVTLELRHAPFFGWLNDLSAPDSSSIINLYGLLPNPAPEPESIMALIFIGILPLLLGISMWLQQKLNPAPTDAMQAQIFAWLPWVFMFMLGSFASGLLVYWIANNTLTFTQQYLIMRSQGFKPDVFGNIRSSFKKKAKEEK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLMH_BACAC
Sequence: MNISIISIGKLKEKYLKQGIAEYLKRLSAYAKVEVIELPDEKAPENLSEAEMLIVKEKEGIRILDKISDDTHVIALAIEGKQKSSEEFAVSLDRLATYGKSKVAFVIGGSLGLSSEVMKRSNESLSFSKMTLPHQLMRLVLLEQVYRAFRINRGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_LACDB
Sequence: MPKHGKKYVEAAKKVDSNKLYSVEDAIKLVKETSYANFDASVEVSYNLSVDPKQADQQIRGSIVLPNGTGKSVKVIVFAEGPQAEAAKAAGADEVGADDLVEKVQNGYLDFDVVIATPMMMAKVGRLGRVLGPKGLMPNPKTGTVTMDTAKAVQNVKAGQVEYRVDRQASIHTAIGKVSFTEEQLTENFRALQNAILRAKPASAKGQYIKSCAVAATFGPGIKLDPIALMA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: GABP2_BOVIN
Sequence: MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATEHHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNANPERANPVTMATPFIFTSGEVVNLASLVSSASTKTTSGDPHASSTVHFSNSTTSVLATLAALAEASAPLSNSHRATANSEEIIEGNSVDSSIQQVVGSGGQRVITIVTDGIPLGNIQTAIPAGGIGQPFIVTVQDGQQVLTVPAGQVAEETVIEEEAEEAEKLPLTKKPRIEEMTNSVEESKEGTERELLQQRLQEANRRAQEYRHQLLKKEQEAEQYRLRLEAMARQQPNGVDFAMVEEVAEVDAVVVTEREMEERETEVTGAVGTAEPHTGVSMETVST
What is the function of this protein?
May function as transcription factor capable of interacting with purine rich repeats (GA repeats).
What are the official names of this protein?
GA-binding protein subunit beta-2, GABP subunit beta-2, GABPB-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCSH_BACC0
Sequence: MSIPNNLRYSEEHEWVKTEGNEVVIGITHFAQNELGDIVFVELPEVGATIEADEPFGSVESVKTVSELYAPVSGKVVAVNEELSDQPELVNESPYEGAWMVKVELSDASQVEKLLTAEKYAEMTNQD
What is the function of this protein?
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
What are the official names of this protein?
Glycine cleavage system H protein, Octanoyl/lipoyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: DRE2_LACTC
Sequence: MSGEKSSLLLIHPAVTTTPELVESVKKSNVFADSSKLDQFLVNKLNDSSVQLEDEKYSLVYYLTPEKESEIQFPTKLIAVLAQSLRGGGRLFGLSDVYKIDALINGFEVVNSGEQGYHWVKKGTAHTQTAPVALRPKRNTPSGGSKSLPIFAKPSFALPAFKKAEKPKPTGLPTFKKPESPRASVVAEDLDDGDELDGMNEDDSNSDELTASKSKFFDDVAGQDSADSIDEDDLVDDAEKSAITVVTCGKTKTRRRKACKDCTCGLKEAEAQEADAARAAQDRILGKPVKFDEQELTEIDFTIQGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPISLDTIADDL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: NEF_HV1BR
Sequence: MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors (PubMed:14990729).
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: MENE_BACCN
Sequence: METMPNWLMQRAFLTPDRIAIETKEEKITFFALHEKVVSVCENLAYLQIKKGQKVAVLMKNGMEMIAVIHALSYIGAIAVLLNTRLSREELLWQMEDAEVICLLTDQIFEPEQVPVYTFEEVENGPKQSVVIQEEFSLAEAMTIIYTSGTTGKPKGVILTYGNHWASAVGSSLNLGLRDDDCWLACMPMFHVGGLSLLMKNIMYGMRVLLVPKYDPDFIHQAIQTKGVTIISVVAKMLTDLLERLGNETYPSSLRCMLLGGGPAPKPLLEACVQKGIPVYQTYGMTETSSQICTLSADYMLTKVGSAGKPLFPCQLRIEKDGKVMPANVEGEIVVKGPNVTRGYFKREDATRETIVDGWLHTGDLGYVDDEGFLYVLDRRSDLIISGGENIYPAQIEEVLLSHPLVLEAGVVGKSDETWGQVPVAFVVKAGQVTEEEMIHFCEEKLAKYKVPKAVYFLHELPRNASKKLLRRELRQLLEEK
What is the function of this protein?
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
What are the official names of this protein?
2-succinylbenzoate--CoA ligase, o-succinylbenzoyl-CoA synthetase, OSB-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
Protein: GCH1_BACAN
Sequence: MAKVNLEQIEHAVRLILEAIGDDPNREGVLDTPKRVAKMYAEVFSGMHEDPKEHLHKVFGEDHEELVLVKDIPFYSMCEHHLVPFYGVAHVAYIPQGGKVTGLSKLARTVDTIARRPQLQERITSTVANSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPGAKTVTTAVRGVLENDAAARSEILSFIKTK
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: MMP8_MOUSE
Sequence: MFRLKTLPLLIFLHTQLANAFPVPEHLEEKNIKTAENYLRKFYNLPSNQFRSSRNATMVAEKLKEMQRFFSLAETGKLDAATMGIMEMPRCGVPDSGDFLLTPGSPKWTHTNLTYRIINHTPQLSRAEVKTAIEKAFHVWSVASPLTFTEILQGEADINIAFVSRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDSEETWTQDSKNYNLFLVAAHEFGHSLGLSHSTDPGALMYPNYAYREPSTYSLPQDDINGIQTIYGPSDNPIQPTGPSTPKACDPHLRFDATTTLRGEIYFFKDKYFWRRHPQLRTVDLNFISLFWPFLPNGLQAAYEDFDRDLVFLFKGRQYWALSGYDLQQGYPRDISNYGFPRSVQAIDAAVSYNGKTYFFINNQCWRYDNQRRSMDPGYPKSIPSMFPGVNCRVDAVFLQDSFFLFFSGPQYFAFNFVSHRVTRVARSNLWLNCS
What is the function of this protein?
Can degrade fibrillar type I, II, and III collagens.  May play a role in the degradation of collagen fibers during uterine involution.
What are the official names of this protein?
Neutrophil collagenase, Collagenase 2, Matrix metalloproteinase-8, MMP-8.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules and released during inflammatory conditions.
Protein: ACPS_ANOFW
Sequence: MIVGIGIDIVELHRVAELMERQPKFIERILTDNEHIRFQQLSSKRKIEFVAGRFAAKEAYAKALGTGIGTHVSFHDIEIKNDENGKPYIISPSMDERVHVSISHSEHYAVAQVIIERLSS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_VIBC1
Sequence: MAHKKAGGSTRNGRDSESKRLGVKRFGGESVLAGNIIVRQRGTKFHAGNNVGIGKDHTLFALTEGKVKFEVKGPKNRKFVSIEAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: NLTPD_BRAOT
Sequence: MAGLMKLACLIFACMIVAGPITSNAALSCGTVSGYVAPCIGYLAQNAPAVPTACCSGVTSLNNMARTTPDRQQACRCLVGAANALPTINVARAAGLPKACGVNIPYKISKTTNCNSVK
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
What are the official names of this protein?
Non-specific lipid-transfer protein D, LTP D, Wax-associated protein 9D.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.
Protein: CYPBA_PSYBR
Sequence: GFNPCGETCIWFPTCHAPGCTCSIANICVRN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide psybry A.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family.
Protein: MACB_NEIMA
Sequence: MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGAGGKERSARADKLLQDLGLASKEGNKPSELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIHKLHEAGHTVIMVTHDPGIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIQEKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSIGTNTISIFPGRGFGDRRSGRIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTQVAEKGLTDLLKARHGTEDFFMNNSDSIRQIVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICVIGGLVGVGLSAAVSLVFNHFVTDFPMDISAMSVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD
What is the function of this protein?
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL11_CLOBK
Sequence: MAKKVVGMIKLQLPAGKASPAPPVGPALGQHGVNIMGFCKEFNAKTANQAGLIIPVVITVYQDRSFSFILKTPPAAVLLKKAAGIESGSGVPNKTKVAKVTKDQIREIAETKMPDLNAGSIETAMSMIAGTARSMGITVEE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.