PharMolix/UniProtQA huggingface dataset:
Protein: IPYR_PONAB
Sequence: MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKRKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINMDDPDAANYNDINDVKRLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTVSESPLKCDPDAARAIVDALPPPCESACTVPTDVDKWFHHQKN
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_LEUMM
Sequence: MQAVGIITEYNPFHNGHIYHIQQAKKLTGADVVVAVMSGNFVQRGEPALFDKWQRTQMALENGVDLVIELPTFFAVQPSHIFADGAIQLLSALGVDNIVFGSEHPEVDFLSIAKQAPTIAEGQEFKNHTQTFASAYAKQLEAETSFKLEEPNDILALGYASAILNQQANIGIIPIQRAEANYHDANFTDEQSIASASSIRLALHKGKTEKIKNVVPEATKVALDTAANTIDFESKFWSMLKYRLTTDTVGQLGQIYQMAEGLEHRFAKTALNDSGPQSYQSFIKSTKSKRYTFTRIQRTLLYTLLNIKVDQMQAAMQDPYLRILGFTSTGQQYLNEIKKQVTLPLISKVDSSLAKSNLRLDYKAGKVWQLLANEGAPTQDVTRMPLYWEK
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INGR1_MOUSE
Sequence: MGPQAAAGRMILLVVLMLSAKVGSGALTSTEDPEPPSVPVPTNVLIKSYNLNPVVCWEYQNMSQTPIFTVQVKVYSGSWTDSCTNISDHCCNIYEQIMYPDVSAWARVKAKVGQKESDYARSKEFLMCLKGKVGPPGLEIRRKKEEQLSVLVFHPEVVVNGESQGTMFGDGSTCYTFDYTVYVEHNRSGEILHTKHTVEKEECNETLCELNISVSTLDSRYCISVDGISSFWQVRTEKSKDVCIPPFHDDRKDSIWILVVAPLTVFTVVILVFAYWYTKKNSFKRKSIMLPKSLLSVVKSATLETKPESKYSLVTPHQPAVLESETVICEEPLSTVTAPDSPEAAEQEELSKETKALEAGGSTSAMTPDSPPTPTQRRSFSLLSSNQSGPCSLTAYHSRNGSDSGLVGSGSSISDLESLPNNNSETKMAEHDPPPVRKAPMASGYDKPHMLVDVLVDVGGKESLMGYRLTGEAQELS
What is the function of this protein?
Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456).  Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:2530582, PubMed:2532365, PubMed:2137461, PubMed:2531896, PubMed:2530216).  Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2.  In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1.  Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:19889125).  STAT3 can also be activated in a similar manner although activation seems weaker (PubMed:15284232).  IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (PubMed:15522878).
What are the official names of this protein?
Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, Interferon gamma receptor alpha-chain, IFN-gamma-R-alpha.
What is the protein family that this protein belongs to?
Belongs to the type II cytokine receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RECF_THERP
Sequence: MLVRSLELEEFRCFRHLHLVLPDRGLRLVGANGSGKTSLIEALYMLATTKSFRASLERHLVHRSSGSELGIPPYARLAAELFTETERSTLEIVLMVDPASGTVRKLYRRDGRSLRAVEFVGTLRVVLFSPEDLELVTGSPQQRRRYLDTILSTIDRAYLRALARYTRILEHRNSLLKSLAERDQRAADEQLAYWDEQLVTYGAYLLVARLRFLAEWGPRLRDHFQALDTQAQVLTTAYLPSIDLPESLLSELAAREVADAQLIVGARYRETLERLRPDELRRGSTLVGPHRDDVEFLLGEEPLTAFGSRGVQRLAVIAAKLAEIAVIHRVTDDWPVLLLDDALSELDQQHRAHLLATLSALPAQLILTATESDVLETPVLSSLPLFRLNDGRLEPG
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCLOT_ARATH
Sequence: MTLKKVDANPSTLESSLQELKSDETSRSKINFILFLADNDPTTGQSWCPDCVRAEPVIYKTLEEFPEEVKLIRAYAGDRPTWRTPAHPWRVDSRFKLTGVPTLVRWDGDSVKGRLEDHQAHLPHLILPLLAPST
What is the function of this protein?
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
What are the official names of this protein?
Thioredoxin-like protein Clot, Thioredoxin Clot, AtClot.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: SSRP_ACHLI
Sequence: MKIITQNKKAHFEYFIEQKFVAGIKLQGSEVKSIRAGKCSINEAYITFRNGEVFILNMHIAKFDASSIFNHEETRTRKLLLNRSEIDKLMGAQTRDGMTIIPLTVELHEGLIKVVIALAKGKKLFDKRETIKERDIKREQQQSLKGKMR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: TDCC_SALTY
Sequence: MSTTDSIVSSQAKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLSNIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYEKEFGREFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASLSGTKSTFATVLEYGASIIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSMGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTLIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUMO3_RAT
Sequence: MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGTASRASVPTPSHFPDICY
What is the function of this protein?
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer.  Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process.  Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.  Plays a role in the regulation of sumoylation status of SETX (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 3, SUMO-3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body.
Protein: METK_GLUOX
Sequence: MRNHGDFLFTSESVSEGHPDKVADRISDTVLDAYLQADPEARVACETLVTTNRVILAGEVRGPKEVEDTLIDRAREAIKDIGYDQEGFSWKKADITSYLHAQSADIAQGVDSGSDKDEGAGDQGIMFGYATRETEHLMPAPLYYAQTILERIRDYRKNGDARGVGLLPDAKSQVTLRYVDGKPVGVTSVVISTQHVEGMSQNTIRETLRDVVNGILPEGWTCPEDEFYVNPTGNFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYAARYLAKNVVAAGLADRCTIQLSYAIGVSKPLSVYVDLDGTGKDVDEARLGAILNEVVDLSPRGIRKHLRLNRPIYVPTSAYGHFGRAPDPVLDNFTWEQTDLVTTLRGALNR
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_MESFL
Sequence: MSRIGNRILTIPAGVEVSVASDNTVTVKGSKGTLTQKFAEVITIKVEGAELSTTRANEIKHTKQLHGTTNSLLQGMLIGVSEGFKKTLDINGVGYRAALAGSKLNLSLGYSHPVEYTIPQGITVECPKPTQIIISGIDKQVVGQVAAEIRSYRRPEPYKGKGIKYSDEIIIRKEGKAAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: O165_CONBU
Sequence: MKLTCVLIVAVLFLTACQLATAENSREEQGYSAVRSSDQIQDSDLKLTKSCTDDFEPCEAGFENCCSKSCFEFEDVYVCGVSIDYYDSR
What are the official names of this protein?
Conotoxin Bu5.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL40_THEKO
Sequence: MARFPEAEARIFRKLVCMRCGATNPWGAKKCRKCGYKGLRPKAREPRGGGR
What are the official names of this protein?
50S ribosomal protein L40e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL40 family.
Protein: VG04_BPMD2
Sequence: MSWAGSKRRQELPEDWELNYRLPVLSAAGWLCEVDGPGCVRAATDVDHKKPGNDHSRSNLQAICRVCHGKKSAAEGVARRRELKARRKRPEQRHPGRR
What are the official names of this protein?
Gene 4 protein, Gp4.
Protein: GUAA_BORBR
Sequence: MHQRILILDYGSQVTQLIARRVREAGVYSEIHAGDVDDAFVRDQVAQGLKGIILSGSHASAYEEGSMRVPAAVFEVGVPVLGICYGMQSMAQQLGGTVSFSDHREFGYAEVRAHGHTKLLDGLADFTTDEGHGMLKVWMSHGDKVTELPPGFKLMASTASCPIAGMADEDRGFYAVQFHPEVTHTVQGKAMLARFVKDICGCEGDWNMPDYISEAVARIREQVGSDEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLDEGKQVMQTFAENMGVKIVHVDATSQFMGKLTGVADPEAKRKIIGREFVEVFQDEAGKLQGAKWLAQGTIYPDVIESAGAKTGKATSIKSHHNVGGLPDTLNLQLLEPLRELFKDEVRELGVALGLPPQMVYRHPFPGPGLGVRILGEVKHEYAELLRRADAIFIEELRNAKDPASGLTWYELTSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTFDFMTADWAPLPHPLLARVSSRIINEVRGINRVVYDVSSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: GATB_ARTS2
Sequence: MSTDATLSFEEAMEKYDPVLGFEVHVELNTKTKMFSSAPNVFGDEPNTNVNEVDLGMPGVLPVVNKTAIESSIKIGLALNCKIAETCRFARKNYFYPDTPKNFQTSQYDEPIAYDGYLDIELSDGTVFRVEIERAHMEEDAGKLTHMGGSAGRIQGADYSLVDYNRSGVPLVEIVTKPIQGAGSRAPELAKAYVAAVREIVKNLGVSDAKMERGNVRCDANVSLRPHGRERFGIRSETKNVNSLRAVEHAVRYEIQRHAAVLDSGEPVIQETRHWHEDTRSTTSGRAKSDADDYRYFPEPDLVPIVASREWVEELRATLPEPPAERRKRLQADWGYSDLEFRDVVNAGVMDEIEETIAAGATATVARKWWMGEIVGRAKNADVDPGQLGVKPETIVELNKMVEAGKINNKMAAEVLDGVLAGEGTPAEIVEKRGLAVVSDDGPLLEAIDAALAAQPDVADKIRGGKVQAIGAIVGGVMKATRGQADAGRVRELILERLGVEG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: MSRA_CLOB6
Sequence: MKEIVLAGGCFWGVEEYMSRIKGIVETKVGYANGIKENPSYKVVCSGTTGHAEACYIKYDESIISLEELLNKFWNIIDPTVLNKQGNDRGTQYRTGIFYLNEKDLNIITESKSREQKNYKKAIVTEVEPLKCFYEAEEYHQKYLKKNPEGYCHIHLD
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: MIAA_BAUCH
Sequence: MLPIAIFIIGPTASGKTNLAIKLRQKLPVEIISVDSALIYRGMDIGTAKPNHEELTQAPHRLINICDPAESYSTANFCLDALNEMTVITAAGRIPLLVGGTMLYFKSLLHGLSPLPPANVEIRTLIQREAKAVGWAALHQKLKKIDLVAANRIHPNDSYRLLRALEVFLVSGNTLTEMIQKSGNALKYQVYQFAIMPVNRSLLHDRITRRFHQMLANGFEYEVSQLFARTDLNTNMSSIRCVGYRQMWSYLAGETNYHEMIFRAISATRKLAKHQITWLKSWQNICWLDSEQQDMALNKILQMISKHIS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: EBR_PSEAI
Sequence: MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFYFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKSLRRPTPW
What is the function of this protein?
One of the determinants for resistance to ethidium bromide and quaternary ammonium compounds.
What are the official names of this protein?
Putative ethidium bromide resistance protein, E1 protein.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOSB_STAA3
Sequence: MLKSINHICFSVRNLNDSIHFYRDILLGKLLLTGKKTAYFELAGLWIALNEEKDIPRNEIHFSYTHIAFTIDDSEFKYWHQRLKDNNVNILEGRVRDIRDRQSIYFTDPDGHKLELHTGTLENRLNYYKEAKPHMTFYK
What is the function of this protein?
Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin.  L-cysteine is probably the physiological thiol donor.
What are the official names of this protein?
Metallothiol transferase FosB, Fosfomycin resistance protein.
What is the protein family that this protein belongs to?
Belongs to the fosfomycin resistance protein family. FosB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_HISS2
Sequence: MKNIRNFSIIAHIDHGKSTLSDRLIQSCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYRAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAAEPERVAEEIEDIVGIDAIDAVRCSAKTGVGIEDVLEEIVRKIPAPEGDPNAPLQALIIDSWFDNYLGVVSLVRVKNGILRKGDKIKVMSTGQSYNVDRLGIFTPKQVDTTELKTGEVGWLVCAIKDILGAPVGDTLTSHHNPATSVLPGFKKVKPQVYAGLFPISSDDYESFRDALGKLSLNDASLFYEPENSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVEQTNGEVIYVDSPAKLPPLNNIAEIREPIAECNMLLPQSYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQAADMVRVDIMINGERVDALALIVHKDNAQYRGRELVEKMRELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSRKKKLLQKQKEGKKRMKSLGNVEVPQEAFLAILHVGKDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL3_AROAE
Sequence: MSLGLVGRKVGMTRIFAEDGRSVPVTVLDVSNNRVTQIKTPESDGYAAVQVTFGKRRASRVGKPLAGHLAKAGVEAGHMLKEFRVETEQVAGFKAGDVVGVDLFAVGQKVDVTGTSIGKGFSGVGKRHNFSSNRASHGNSVSHNAPGSIGMAQDPGRVFPGKRMAGQYGNTTCTTQGLEVVRVDVERQLLLVKGAVPGSKGGDVIVRPAVKARG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: CRCB_BURP0
Sequence: MFYSIVAIFVGAGLGALLRWFLSIGLNALLPEVPLGTLASNLIGGYLIGIAVVAFATRAGLPPEWRLFVITGFMGGLTTFSTYSVEVMTHAVQGEFGWALAVAALHLIGSFTLTGLGMWTARAWLAPA
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPO3_SCHPO
Sequence: MGILSVIRIFIYCLIRLFSFNSRKRNSSIDELERGEINAFACDKQNTPSPNSECRPLTPLNSPFRRTVEGDTANLQAPSPTACPSFDSASSIKSSKEDIACRKLSTERFFYSPNGIDEMKKQQQFKKIPTVSITEVEPAFIPSNMEQALFSEEPFVIQDDLSHQINLDDNRKFSRIQKNKLDPLITVNLVPIVNGENCFNFYETQMETNFLSPEFIKKPSMVDHKRDSEINAVTAVSADGSFSPLTETLSSTISTLSNDSLDGLSSQKNEFTGFNSNSEWIPNDTVDYICNSDASSVVSNLSDFEDCFDQFGVYDKEYEKKIEKTKRNFPKFQSSATYPPFSAHHQARRNNPQGFRNVKKRFQLFKDDCTALTDSDFLDALPFFNARVIIALYVEWRLRVYETMIIKGEESLKNLQRARDGPHNKLWLGVFGNKDTIKKLSNYDRRAISNPYVSNHLNFNVRRVKSDTVYIPTILQLLRSSTQLMTEQAFVASSNLKSTKGLRETRLIQKYKVKGDFEYVYAALYYAAFTQESTLKAVTIDDILSEDELEDWWYLNLRYTSFITPQLCFEFLDKEADSCRDRLTEVKSEPPKAVIYEEPLNKLSRFSSDRLFTSHELVAIAELISLNEPPLESGKKFYYEEFQKACQKKRDDYRYSPEIEFKAAFREKFLQSNEKVPFPRPGEIYEKRCDYFSKYACQNIFISKPLKRSGSIYEVFSDGIGRVIYGSVLDYEATRNNILLHFGFEIHCAPSEEELIEREEAFKDFHNMLSFKYSANEIYEFCGTHSRAEVHKNEVLKRMAYYLIDENKEISILRRILSLRIVEPTTSFTRYEYDLWRTFYPDVLYLNYSKSGRIPTGSPYIMNGQWRKDLCVSTPPMVDINSALFPHWFKLSASNLFAGAEHAGLNRQKPDKIDLDLYEPLPENSYLVAAELRVLRALRHKNPENIPLLEKWEVRALHQLMAKIRKYYTVPTDYLSLRMDGLQAMLRKREYMSCYTFNYFDYACLMDHAYRLYEGFNNQVVNLPPRIM
What is the function of this protein?
Has a role in spore morphogenesis.  Involved in the assembly of the forespore membrane.
What are the official names of this protein?
Sporulation-specific protein 3.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Prospore membrane; Peripheral membrane protein. Note=Associated with the plasma and forespore membranes.
Protein: RPB3_MOUSE
Sequence: MPYANQPTVRITELTEENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLHDEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB3, RNA polymerase II subunit 3, RNA polymerase II subunit B3, DNA-directed RNA polymerase II 33 kDa polypeptide, RPB33, DNA-directed RNA polymerase II subunit C, RPB31.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLND_ECO7I
Sequence: MNTLPEQYANTALPTLPGQPQNPCAWPRDELTVCGIKAHIDTFQRWLGDAFDNGISAEELIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDVDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVRNSAITGIYSTTLRQLRHARRHLQQPLCNIPEARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSTELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLSADRHEVIQFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: SDHD_SALPA
Sequence: MENIQKLIARYPLVEDLVALKETTWFNPGTTSLAQGLPYVGLTEQDVNAAHDRLARFAPYLAKAFPQTAAAGGMIESDVVAIPAMQKRLEKEYGQTIDGEMLLKKDSHLAISGSIKARGGIYEVLTHAEKLALEAGLLTTDDDYSVLLSPEFKQFFSQHSIAVGSTGNLGLSIGIMSACIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEDDYGVAVEQGRKAAQSDPNCFFIDDENSRTLFLGYAVAGQRLKAQFAQQGRVVDASHPLFVYLPCGVGGGPGGVAFGLKLAFGDNVHCFFAEPTHSPCMLLGVYTGLHDAISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGLYTLDDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRICAATEYQQRHGFSQTQLGNATHLVWATGGGMVPEDEMEQYLAKGR
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.