PharMolix/UniProtQA huggingface dataset:
Protein: RLMD_BURCH
Sequence: MSEAVPTSARKSKNAPVAPGPAPVLEIESLDMEARGVGRTMTEDGEPGKVIFVEGALPGERVTYSSYRRKPSYEQATVVDILRPSVMRTQPKCTFFGTCGGCSMQHLDMRAQVAVKQRVLEDNLWHLAKLRAETMFAPIHGPSWGYRYRARLTVRNVAKKGGVLVGFHEKKSSYVADMTSCEVLPPHVSAMLVPLRRLVEGLSIRDRMPQIELAVGSTVTALVLRVLEPINADDEALLRAFADEHKVQFWLQPKGPDTVTPFYPLDVSLDYTLPEFGIRMPFKPTDFTQVNHQINRVLVGRALRLLAPSRDDRVLDLFCGIGNFTLPLARLSREVMGIEGSDTLTTRALANARENGVDGHTTFACRNLFEVTGDDLRALGAFDKFLIDPPREGALAVSKALAEIAQSGAGPLPKRIVYVSCNPSTLARDAGLLVHEAGYRLKGAGVVNMFPNTSHVESIALFERD
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: EMC1_XENLA
Sequence: MAADLCWLSLLLASLALSGAVYEDQVGKFDWRQEYVGRIKFASLESGLGAKKLIAVTDKNIIAALNSRTGDLLWRHVDKDTSEGTVDALMMIGQDAITVSGGRLLRSWETNIGALNWEAALEPGSFQAVSFAGSQDTARYVAVLKNSALSLYFLSNGHLKWSESLPESDTVQYQLLYSPYKGSVHVVGLVPHSHLTILTFSLEDGSISHQVRVLTPWLRTLHGTCGVIGEGVLVCGDVPMASVHIVSLLSGEETTRYSVQSLDIELAEDPTQLDVITAPQNGIGGSLSQFFLQIAPRRFLLMHYHDGVLTPLRDFSQVSLVNFATTGEKTVVAVMQCKTEGNPKSGAESEYLTGQNCAQEPWYCPGHTYSINLYMADSGRRLLETTMSFTLDQICVRPDSFYLQTFLRKDDSVGYRALVQTEDNQLLFLQQPGKLIWLREESLADVVTMETVDLPLTGAQAELEGEFGKKADGLIGMVLKRLSSQLILLQSWSAHLWKMFCDARKPRSQIRNEINVDTLARDDFNLQKMMVMVTASGKLFGIESSSGSILWKFYLHGVHPGSSFKLLVQRTTAHFPHPPQCTLLVKDKVTEKSAMYVFNPIFGKLSQLAPPPLQRPILQSLLLPIMDNDYAKVLLLLDDQHKVIAFPATKYVLQQLQELHSTIFFYLVDVEKGKLSGLRLNKDLSTEEIWEVLLPADQQRITVVKGKRSNEHVHSQGRVMGDRSVLYKYLNPNLLVLVTESTDTHPERCFIGIYLIDGVTGRIIHSSVQRRARGPVQIIHSENWVVYQYWNSKARRNELTVLELYEGTEQYNSTNFSSLDRPLLPHVLQQSYIFPSAIRAMQATITERGITSRHILIGLPSGAILSLPKALLDPRRPEIPNEYTREENLIPYTPDIQIHAERFINYNQTISRMRGIYTAPSGLESTCLVVAYGLDLYQTRVYPSKQFDVLKDDYDYILISSVLIGLVFATMITKRLAQVKLLNRAWR
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the EMC1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RS21_IDILO
Sequence: MPVVKVKENEPFDVALRRFKRSCEKAGVLSEVRRREHYEKPTSERKRKKAAAVKRHAKKLSRDNARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ENO_PSECP
Sequence: MALIDAIHAREILDSRGNPTVEVEVLLSDGQIGRAAVPSGASTGEHEAVELRDGDKGRYLGKGVQKAVDAVIDQIAPALTGFDATDQRSIDQAMLDLDGTPNKGKLGANAILGVSLAVANAAAASADLPLYKYLGGPNAHVLPVPLMNILNGGSHADSDVDIQEFMIAPIGAETFSEGLRWGVEVYHNLKSVLKEQGLSTGLGDEGGFAPNLPSNRAALDLIQEAIKNAGYTPGKDIALALDVASSEFFKDGAYQFEGKALSASEMSAYYAELVADYPLVSIEDPLDENDWEGWKTLTDAIGDKVQLVGDDLFVTNPAILQRGIDTRTANSLLVKVNQIGSLTETLDAVSLAQRAGYTTITSHRSGETEDTTIADISVATNAGQIKTGAPARSERVAKYNQLLRIEEELDDAARYAGRSAFPRFKG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: Y3370_XANC8
Sequence: MSRVNTMHQWKERLRDRARTASFGRFLWRRFLDDRLFQAAASLAYTTVFALVPLAIVVFGVLSAFPAFNEWKDALTDFIFNNFVPGAARSVQNYLNRSLEDLGKFTVAGMVALVASLLITLHSIEQTFNSIWRVAAARPKVTRFLIYWTVLTLGTMLAAASMAMAAYVFALPLFRTTEGQWLAEFAWRLAPMAVEFVCIVLIYRVVPQHAVRLRHALPGALLAVILMEIVKWGFGFYLGNFQTYQRIYGALSALPILLLWIYLSWVSVLLGASLASSMSAFRYQPEAMRLPPGFEIYGLLRLLGRFRQARLHGNGLDEDRILALEPMLTDTLMQELLCELKRIRLLRRDERGNWLLARDLDVVPLAELYESCQLRVPVEDRPLPCRDDPYGQAAAAALEQLRQPLRSVLAQPVGDLYTHLPGDPP
What are the official names of this protein?
UPF0761 membrane protein XC_3370.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLMU_DEIRA
Sequence: MTEQTRPLDVVILAAGQGTRMNSALPKVLHPVAGRPMVAWAVKAARDLGARKIVVVTGHGAEQVEAAVQQPGVAFARQERQLGTGDAFLSGASALTEGGADILVLYGDTPLLRPDTLRELVASHREQGSAMTVLTGELPDATGYGRIVRGEGGAVERIVEQKDASDAEKAIGEFNSGVYVFDERAPELARRIGNDNKAGEYYLTDLLGLYRAGGATVRAFRLSDPDEVLGANDRAGLTQLEATLQRRINEGHLKAGVSISLPGTVLIEDTVEIGRDVVIEPGALLRGQTRIAGGAVIGAYSVITDSVIHERAVIKAHSVLEQAEVGAGSDVGPFARLRPGSVLGEGVHIGNFVETKNARLDAGVKAGHLAYLGDVEIGAETNVGAGTIVANFDGLNKHQSKVGAGVFIGSNTTLIAPRVVGDAAFIAGGSAIHDDVPEGAMAVARGKQRNIEGWARRYWAAPERREKLAKKLPWLAGWLSRTQG
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTU_AGRFC
Sequence: MNNPRHNIRDVRAPQGTELNAKSWMTEAPLRMLMNNLDPDVAERPHELVVYGGIGRAARTWDDFDRIVATLKDLNEDETLIVQSGKPVGVFRTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEAGRQHYDGNLKGKWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRVDFRLRTRYVDAKAHTLDEALALIDQWTKAGEAKSVGLIGNAAEIFPELFRRGVRPDIVTDQTSAHDPIHGYLPAGWTVAEWRAKQESDPKAVAAAARASMKVHVQAMVDFWNAGVPTLDYGNNIRQVAKDEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELLPDNKHLHNWLDMARERIAFQGLPARICWVGLGDRHRLGLAFNEMVRNGELKAPVVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVICADGTDDAARRLERVLWNDPATGVMRHADAGYDIAVECAKEQGLRLPGILGN
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_LEGPN
Sequence: MSSVSIVDYGVGNLLSVARAFQYFDASVNLVSTPEEIMSADRLVLPGVGAFEDGMKGLTTLNFIEPIKQFARSGKPFLGICLGMQMMLSRSTEFGQHEGLDLIAGEVVSVPSHGVDGQLHKIPHIGWNELVSTSEGEDWCHTILKNIPLNSSVYFVHSFMAMPSNPKKRLADTLYDGQAISAVIKDENMYGCQFHPEKSGEVGLSIIQQFLQI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_PSEU2
Sequence: MTDHALLLVNLGSPASTQVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSKRLQQAMKKEWSHGPVELAMRYGEPSIETVLTRLAEQGFKKVTLAPLYPQFADSTVTTVIEEAKRVVRAKSLKMQFSVLQPFYDQPEYLSALVESVRPHLEQPYDHLLLSFHGLPERHLHKLDPTGKHCLKDDCCMTAPAEVLATCYRAQCIQSAAAFAKRMGIADGKWSVSFQSRLGRAKWIEPYTEAHLDELAAKGVKKLLVMCPAFVADCIETLEEIGDRGAEQFKEAGGEELILIPCLNDDPNWAKELNRLCERAPLML
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRM2B_MOUSE
Sequence: MVKKRLSSSDNVFKFEIPSNSKTSAEAPHSSTDSPSSVFLSSEAENGAEDRRRVSKSPTAQSPTSSVEAESPDQKRSLGLWSKSSFDGSSLLSDKNDCKTESKTDSKTERKKSSSSSQYKANMHFHKLFLDVPTEEPLRQSFTCALQKEILYQGKLFVSENWICFHSKVFGKDTKISIPAFSVTLIKKTKTALLVPNALIIATVTDRYIFVSLLSRDSTYKLIKSVCGHLENTSVGNSPNPSSAENSFRADRPSSLPLDFNDEFSDLDGVVRQRRQDLEGYSSSGSQTPESENSRDFHVTESQTVLNVTKGETKPPRTDAHGSRAPDGKAKILPAHGQSETIGILHKMESRKCPTLHHILIVYAIIVCALIISTFYMRYRINTLEERLGTLTSIMDPHSTEQTAPSGLGSQMQLNVEVLCQELTANIVKLEKIQNNLQKLLENGD
What are the official names of this protein?
GRAM domain-containing protein 2B, GRAM domain-containing protein 3.
Protein: MNME_STRSV
Sequence: MITREFDTIAAISTPLGEGAIGIVRLSGTDSFAIAQKIFKGKNLSEVESHTLNYGHIVDPQNQEILDEVMLGAMRSPKTFTREDIIEINTHGGIAVTNEILQLAIREGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMNNAVKQLDGSLSNLINNTRQEILNTLAQVEVNIDYPEYDDVEEMTTQLMREKTAEFEALLSNLLNTARRGKILREGISTAIIGRPNVGKSSLLNNLLREDKAIVTDIEGTTRDVIEEYVNIKGLPLKLIDTAGIRETDDLVEQIGVERSKKALQEADLVLLVLNASEPLTDQDRQLLEISKDSNRIVLLNKTDLEEKIELDLLPTDVIKISVLHNQNIDKIEERINQLFFENAGIVEQDATYLSNARHISLIEKALESLQAVNQGLEMGMPVDLLQVDMTRTWEILGEITGDAAPDELITQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOT_DROPS
Sequence: MSRKNVLNLINTIVANSCKCPAHSHNYGSAAPTGVQTGQKEYAFEMSASTVRFGPGVSVEVGADLRNLGAKKVCLVTDRNVAKLPSVKVALDSLARHGINYEVYDETRVEPTDASLWHAADYARQNEFDAFLAIGGGSVMDTAKAANLFSSDREAEFLDYVNCPIGKGKEISVKLKPLIAMPTTSGTGSETTGVAIFDYKRLHAKTGISSKYLKPTLAIIDPLHTLSQPERVMAFAGFDVFCHALESFTAVDYRERGPAPSDPSLRPTYQGRNPISDVWARFALETIRKNFINAIYEPGNLEARSQMHLASTMAGVGFGNAGVHLCHGLSYPISGNVRNYKPAGYTADHALIPHGLSVVISAPAVFEFTAPACPDRHLEAAKLLGAKVDGVRASDAGRLLADTVRGFMQRAGIENGLRELGFSSSDVPNLVDGTLPQERITKLAPRAQTQENLAQLFENSMVAY
What is the function of this protein?
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG).  L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).
What are the official names of this protein?
Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial, HOT.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YCF4_AMBTC
Sequence: MNWRSERIWIELITGSRKTSNLCWACILFLGSLGFLLVGTSSYLGRNLISLFPSQQILFFPQGIVMSFYGIAGLFISSYLWCTILWNVGSGYDRFDRKEGIVCIFRWGFPGRNRRIFFRFLMRDIRSIRMEVKEGIYPRRVLSIEIRSQGSIPLTRTDENFTPREIEQKAAELAYFLRVPIEVFRTKEWILSRHGVGNPRILFNTTDLSSEQLLIRSKHVSVRSYFRSLLFPVCG
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SYV_RHILO
Sequence: MLEKTYDAKTVEPKIAKVWEEADAFRAGAGAEEGAEAFTIVIPPPNVTGSLHMGHALNNTLQDILVRFERMRGKNVLWQPGMDHAGIATQMVVERQLMEKQIHRRDLTREQFIEKVWEWKAESGGTIFNQLKRLGASADWSRERFTMDEGLSKAVLEVFVTLYKEGLIYKDKRLVNWDPRLLTAISDLEVEQHEVNGNLWHFRYPLEGETFDPENPKTFITVATTRPETMLGDTAVAVHPDDERYRHLVGKNVVLPIVGRKIPVVADEYSDPEKGSGAVKITPAHDFNDFEVGKRHKLPAINILTVEAAIKLKDNEDFLAGLDATPERQAVWDELDGLDRFVARKKIVELMEEGGFLEKVEPHRHAVPHGDRGGVPIEPFLTEQWYANAAELAKPAIASVREGRTNFVPKNWEKTYFDWMENIQPWCISRQLWWGHQIPAWYGPDGRVFVEKTEEEALSAAIEYYLALEGPWKAWVEDRLENFQPGEILTRDEDVLDTWFSSALWPFSTLGWPDQTPELKTYYQTDVLVTGFDIIFFWVARMMMMGLHFMDEEPFHTVYVHALVRDKNGAKMSKSKGNVIDPLDLIDEYGADALRFTLTVMAAQGRDVKLDPARIAGYRNFGTKLWNATRFAEMNEVARNDDFWLNDAKLAVNRWILTELTRAARQITDGITSYRFNEAAGAAYRFVWNLFCDWYLELLKPVFMGTDEAAKAESRACVAFVLDEIYKLLHPMMPFMTEELWAQTAGEGKERESLLCHAAWPSPDFEDDEAAADINWLVDLVSGIRSVRSEMNVPPAAIAPLVVVGANGVTRERLVRQDSAIKRLARVGDISLADAAPKGSAQIVLNEATICLPLGSLIDLAAEAARLQKELAKVTEEIARLHKKLSNERFVASAPAEIVEAEREKLAEYRDAQDKLAVALTRVRDAG
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_CUPTR
Sequence: MLNFELITTDGNARRGRVTLNHGVVETPIFMPVGTYGSVKAMSPLELNEIGAQIILGNTFHLWLRPGLDVVNAHEGLHRFIGWDKPILTDSGGFQVFSLGDLRKITEDGVTFASPVNGDKLFLSPEISMQIQRTLNSDIVMQFDECTPYEIDGRPATHEEAAKSMRMSLRWARRSRDEFERLANPNALFGIVQGGMYEDLRDESLAGLSELDFHGFAIGGLSVGEPKEDMMRVLEHVAPRLPANKPHYLMGVGTPEDLVAGVAAGVDMFDCVMPTRNARNGWLFTRYGDVKIKNAAHRNDPRPLDESCACYTCRNFSRAYLHHLHRVGEILGARLNTIHNLHYYLQLMREVREAIEQHRFADFRRQFAADRARGTQ
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: CH60_ECO24
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKLADLRGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKNDAADLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3B_VIBCH
Sequence: MKFTIERSHLIKPLQQVSGTLGGRASLPILGNLLLKVEENQLSMTATDLEVELISRVTLEGEFEAGSITVPARKFLDICRGLPDSAVITVLLEGDRIQVRSGRSRFSLATLPASDFPNIEDWQSEVQVSLTQAELRGLIEKTQFSMANQDVRYYLNGMLFEIDGTTLRSVATDGHRMAVAQAQLGADFAQKQIIVPRKGVLELVKLLDAPEQPVVLQIGHSNLRAEVNHFVFTSKLVDGRFPDYRRVLPQHTSKTLQTGCEELRQAFSRAAILSNEKFRGVRVNLADNGMRITANNPEQEEAEELLDVSFEGEPIEIGFNVSYILDVLNTLRCDNVRVSMSDANASALVENVDDDSAMYVVMPIRL
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3_LATSS
Sequence: MALDQTALFQKLLEQIALPADVAHYPGFKTGQVEQVIVHETSKRWTFKLHFDNVLPFAVYTAFEEHLEAAFQAIAAVSIEISTDAKELDGGVLAAYWEYVVNHSGIQSSLLHELCAKETPYIEGRKVLLVVENDIVKTFFINQAQTTIQAGYKRLGFPNFAIQPLIDESASQKSIEDFQAKRAVQDAERAQAAAEAIKKNEALKEKRKTEGKPVDGPIVMGRGINPAEPVRQMISITEEERSIVIEGFIFDKEVRVLRSGRQLLILKMTDYSSSFTVKKFSRDASDESLFAAIDKGMWFKVRGSVQEDNFMRDLTVNANDLVEVSHPKREDTATDGKRIEMHLHTNMSQMDATNPIGDYVKQAAKWGQPAIAVTDHYNLQAFPDAYAAGKKNGVKILYGVEVNLVNDGTPVVYNLRDQVLESAEYVIFDVETTGLSAVYDSIIELAAVKMRDGEVVASFDEFIDPERPLSAFTTQLTSITNEMVHGAKKEAEVLAMFKEFTGDAVLAGHNVSFDMGFLNAGYERNDIDLIDNPVIDTLELSRMLHPEYKNHKLDSLTKRYKINLEHHHRANADAESTGYLLYKLEKEAAENYDMVNVNQLNDRVGVGEFYKQARPAHAVLMAQTQAGLKNLFKLVSASMTEYYYRTPRLPKSKLDALREGILVGSACSNGEVFEAMMQKGYNEALDRAKYYDYIEVMPKAVYAPLLERELVRDNRALEEIIRNLVKVGEKLNKPVVATGDAHYLNPEDAIYRKILIHSMGGANPLNRSKLPDVHFRSTDEMLTAFDFLGPELAQELVVANPQKIADQIDEIVPVKDKLYTPKMAGAEDEIQTLTMNRAHELYGAELPEIVEARLKKELKSIIGNGFSVIYLISQKLVYKSGKDGYLVGSRGSVGSSLVATMTGITEVNPLPPHYRCSNCHYSEFFTKGEVGSGYDLADKDCPECGTPLDKDGHDIPFETFLGFHGDKVPDIDLNFSGDYQPVAHNYTKVLFGENNVFRAGTIGTVADKTAYGYVKAYERDTEQTFRGAEVDRLAKGSTGVKRTTGQHPAGIIVVPDYMDIYDFTPIQFPADDQDAAWKTTHFDFHSIHDNILKLDILGHDDPTMIRMLQDLSGIDPKSIPTDDPGVMALFSGTDSLGVTPEQINSKMGTLGVPEFGTRFVRGMLEETHPTTFSELLQISGLSHGTDVWLGNAEELINKGVVTLKDVIGCRDNIMMDLIHWGMDDSMSFNIMERVRKGKGIPDDWQQAMRDNENVPDWYIDSCLKIKYMFPKAHATAYILMALRIAYFKVYFPIIYYCAYFSVRASDFDLVAMAQGKEGVKARMKEITDKGMEASTKEKNLLTVLEIANECLERGITIKMVDIEKSDSSDFLIQDDHTLLAPFRAVPSLGDNVAKQIVSAREEKPFLSKEDLSNRGKVSKTLIEYLTENNVLNDLPDENQLSLFDMM
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTH_ECOL6
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAKRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQIERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYG_ELEMA
Sequence: MGLSDGEWELVLKTWGKVEADIPGHGETVFVRLFTGHPETLEKFDKFKHLKTEGEMKASEDLKKQGVTVLTALGGILKKKGHHEAEIQPLAQSHATKHKIPIKYLEFISDAIIHVLQSKHPAEFGADAQGAMKKALELFRNDIAAKYKELGFQG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: DEOD_BUCAT
Sequence: MSTPHINSKKDDFSDIVLMPGDPVRAKYIAEKYLSNFVQVNDTRLMLAYTGFYKNRKISIMSHGIGIPSASLYTRELIIEFNVKKIIRIGTCGAVRDDIKLRDIVISMGASTDSKVNRIRFNDHDFAAIADFDMIYNIVSISKKMKIKVSIGNFFTTDSFYNDDKKMLNILKKYNIIGVDMETAGIYGVASELKVQALSICTVSDHITNKEFLSSKERESSFNDMIELALESVL
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: TRPD_RHILW
Sequence: MTDLKPFLAKAASREPLTRDEARAAFDILMSGQATPSQIGGFLMALRVRGETVDEIVGAVTAMRSKMLTVEAPEDAIDIVGTGGDASGTYNISTLAALIVAGAGVPVAKHGNRALSSKSGAADNLAALGVKLDVGPEIISRCIAEAGVGFMFAQLHHSAMRHVGPSRVELGTRTIFNLLGPLSSPAGVRRQLLGVFSPQWLVPLAEVMRDLGSECVWVVHGDGLDEITTTGITKVAALEDGKIRTFELSPADFGVSPCVLADIRGGDGVANAAALREVLSGAKNAYRDISLANAAASLVIAGKVETIRDGMTLAAQSLDSGATALALDKLIAVSNDID
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: MDTL_SHEON
Sequence: MFRYLLCSFGLVLMYPTGIDMYLVGLPQIASQLGASEAQLHIAFSVYLAGMATTMLFAGSLADRIGRKPITLFGALLFALASYFAAGSQTSDLFLIARFAQGIGAGCCYVVAFAILRDVLDDKRRAKVLSMVNGVTCIIPVIAPVIGHLIMLKFPWPSLFYTMAAMGLLVFALCLLVLRETHSKAAFHTQALPGVQRESFKQGFFISRLVITTLGVTTILSYVNVSPMLIMGQMGFDRGQYSNTMAMMALVSMLASFSTPFLLNRFKEKSLILFSQGLFVAAALVFILTQLGGVSHSFNLLGFAFVCSGFSIGFGVTMSQALSPFVARAGVASSLLGIAQVCTSALYIWVMGLLEVSAINILLLILSVGALVSITLMLAVPKMSEMVVNEQIPESA
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.