PharMolix/UniProtQA huggingface dataset:
Protein: GB_SHV1
Sequence: MAPPAAKSRASRVAPLTSLVSMLAAAAAAVALCAAFAEAARGVTPVYSDDADESSESIITGGAELPGEDAGPPGPEPGLPDRPTKPRKPRPGRRQRANKTREDARAQLRESVRQIRAENATSMFYVCPPPTGATVVQFEEPRPCPDVAAGKNFTEGIAVIFKENIAPYKFTATMYYKEITVTQTWQGSRYLQLTGLYNDRAPVPFEEITDVINAKGLCRSDVTYVRSQRRVTAYDRDEWGREVKLVPSKTSTPNSRGWYTTDRMYAPNAHAGFYKAGTTVNCIVEEVEARSAYPYSNFVLATGDFVYVSPFYGLGEDAHREYNAYSADRFKQVDGFFPRDLDSGETAPEPVVRNLLTTPKFTIGWDWKPKDPSVCSVTKWQEVEEMMRAEYGSTFRFTSSSLSATFTTNVTQYPPQRIELSDCVAREAQAAVDAIYARRYNASHVKVGGLQYYLAQGGFLVVYQPLISNSLAEMYLREAEARALEPAPLPTTPAPEAAGSRGTLSTTQSVEFARLQFTYDHIQKHVNEMLGRIAAAWCQLQNQELVLWNEARKLNPNAIASATVGRRVGARMLGDVMAVSTCIAVAPHNVIMQNSMRLPARPKTCYARPLVSFRYADEGELIEGQLGEDNEIRLEQNNLEPCTVGHKRYFVFGDGYVYFEEYAYSHQVSRADVPVVSTFVDLNLTMLEDHEFLPLEVYTRQEIKDSGLLDYAEVQRRNQMHALRFSDIDHIINDTTNAALMDGLFRFFDGLGAAGQAIGKAVLGVTEAVISVVSGVSSFLSNPFGALAVGLLVLAGLTAAFFALRYIMRLRANPMRALYPITTHGIKAEAKASLASGEPRSGPGGIEDFDEAKLEEARTMIKYMTLVSAMERTAHKAKKRGTSARISRHLTDMVLRKRNTARPPSSEYQPILEDEDDAAV
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: YCF4_ILLOL
Sequence: MNWRSERIWIELITGSRKTSNFCWACILFLGSIGFLLVGISSYLGRNLISLFPSQQILFFPQGIVMCFYGIAGLFISSYLWCTISWNVGSGYDRFDRKEGIVCIFRWGFPGINRRIFLRFRMRDIRSIRMKVKEGLYPRRVLYMEIRGRGDIPLTRTDENLSPLEIEQKAAEWAYFLRVPIEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SYR_SHEB2
Sequence: MKSHIQSLLEQTLESFKQQGIVPADFEARIQVDRTKDKSHGDLATNLAMMLTKVAGKNPRELAQLIIDTLPASAYVAKVEIAGPGFINFFINDSALADQLQNAVNDEHLGIKLPTPQTVVVDYSSPNLAKEMHVGHLRSTIIGDSVVRALEFLGHKVIRQNHVGDWGTQFGMLLAYMEELRAKNGEKAQLELSDLENFYRAAKLRFDESAEFATRARQLVVELQSGDEYCNKLWREFNDISLSHCHEVYARLGVSLTRADVHGESAYNADLEQVVKDLDAQGLLTESNGAKVVFQEAFRNKEGEPLPVIIQKADGGYLYATSDLAAMRYRSNVLKADRVLYFVDLRQALHFQQVFSLAKLAKFVREDMSLEHLGFGTMNGEDGRPFKTRSGGVVKLVDLLEEANVRALELVRSKNPDMDEVTLTEIARVVGISAVKYADLSKNRTSDYIFSFEQMLSFEGNTAPYLLYAYTRVAGIFKRVTDLDLSQAKIVLEHEKEKDLGNKLAQFGEILSRVVDKGQPHVLCAYLYELAGAFSSFYEACPVLAADNDAQKNSRLLLAQLTARTLQKGLNLLGIETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_SACD2
Sequence: MTDYKATLNLPQTSFAMKANLAQREPGMLKQWQQSKLYEQIREARKGREQFILHDGPPYANGDIHIGHAVNKILKDIIIKAKTLSGFDAPYVPGWDCHGLPIEHNVEKKVGKAGVKIDHVAFRQKCRDYARKQVEGQKKDFIRLGVLGEWDTPYLTMDFKTEADTVRALGKIVENGHLHKGFKPVYWSVVGASALAEAEVEYQDKTSFAIDVCFGVADVEDFAARVGSVAGTGNISVVIWTTTPWTLPANQAVSVNGELDYVVVQHGEQRLVLAEALVESVAKRLGVEELATVATFKGAAIEGLKLNHPFYAKQVPVLLGDHVTTDAGTGCVHTAPDHGADDFVVSNKYGIETLNYVDENGIYRDNVEIFAGDHVYKVDEKVIGLLEENGRLLHQAKLVHSFPHCWRTKTPLIFRATPQWFVSMTKNNLLKDVKQAVEGVNWVPDWGRARIDSMLDSSPDWCISRQRTWGVPITLFVHKETQELHPNTAALVEDVAKRIEEKGMDAWFELDAVELLGDEADQYQKVTDTLDVWFDSGVTHYSVVNARENLRYPADLYLEGSDQHRGWFQSSLKTSMAINGSAPYKQVLTHGFTVDADGKKMSKSIGNTVSPQKVMNDLGADVLRLWVAATDFSGDMSVSDEILKRTADSYRRIRNTARFFLSNLTGFNPQTDLLPAEEMLSLDRWAVDRAAALQADILKSYDTYQLHQIYQKLHNFCVVEMGGFYLDIIKDRQYTTKETSHARRSAQSALYHIVEAFVRWIAPICSFTADEIWQAMPGEKTGTVFTAEWYNLPRLAEGAELGNSYWQFIAKVKTAVNKTIEAKRSAGEVGGSLAAEVTLYCSESVAQKLTLLKDELRFVLICSSVTVVAASETEGEATEVEGLRVAVAKSSHEKCARCWHHREDVGQNTAHPEICGRCVENIDGEGESREFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYCP1_MESAU
Sequence: IVELQFEKEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETSARSAEKTNKYEYEREETRQVYVDLNNNIEKMILAFEELRVQAENARLDMHFKLKEDHEKIQHLQEEYKKEVNDKENQVSLLLIQRTEKENKMKDLTFLLEESRDKVNQLEDKTKLQDENVKELNKKKDHLTSELEDTKMSLQRSMNTQKALEEDLQIATKTIYQLTEEKEAQMEEFNKAKTDHSFMVTELKATTCTLEELLRTEQQRLVKNEDQLKILTMELQKKSNELDEMTKFKNNNEVKLEELKKILAEDQKLLDEKKQVEKLAEELQGKEQELTLLLQTREKEVHDLEEQLLVTKISDQNYSKQVEELKTKLEEEKLKNAELTASCGKLSLENNKLTQETNDMALELKKYQEDITNSKKQEERMLKQIENLEEKETHLRDELESVRKEFIQQGNEVKCKLDKSEENARSIECEVLKKEKQMKILENKCNNLRKQAENKSKYIEELHQENKALKKKSSAESKQLNAYEIKVNKLQLELESAKQKFQEMTDNYQKEIEVKKISEEKLLGEVEKAKAMVDEAVKLQKEIDLRCQHKIAEMVALMEKHKHQYDKIVEERDSELGLCKNREQEQLSVKTALETELSNIRNELVSLKKQLEIEREEKEKLKLEKENTAILKDKKDKKIQTSLLESAETTCQKFDSKTTPSQNISRISSSMESGKTKDNRDCLRTSAKILSTAFVKEYTVKTPTKMQMYQRENKYIPTGRSNKKRKTVFEFDVNSDSSETTDLLSMVSEEEISNRLYNNNSPNSHLTPKQTPLSLSTPESFVSLGGVRKMREDRWATIAKTDRKRRLKEAEKLFA
What is the function of this protein?
Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (By similarity).  Has non-specific DNA binding capability.
What are the official names of this protein?
Synaptonemal complex protein 1, SCP-1, Meiotic chromosome synaptic protein.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex.
Protein: APOA2_PANTA
Sequence: MKLLAMTVLLLTICSLEGALVRRQAEELSLQRLVSQYFQTVTDYGKDLVEKAKGPELQAQAKAYFEKTQEQLTPLVKKAGTDLINFLNNFMDLKAQPATQ
What is the function of this protein?
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
What are the official names of this protein?
Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ADD_CLOB6
Sequence: MNFKKLPKIELHCHLDGSLRVDTILDIAKKDNIPLPSYNEKELINYVSIMDDCNSLDEYLNKFFIPNKVMQTKENLKRIAFELLEDVAADNVKYIEVRFAPLLHVEKGLNIEEIIESVLEGIKEAEKLYDIKGNLILGCMRNMDIPSAFEVVKKGAKFIGKGVVAIDLCGGEEPHFPGKYVEVLKLAKEYGYRITIHAGEAGVGENVLEAINLLNAERIGHGIYIKNCAEAYKLVKEKNIPLEVCPTSNLHTKAFESYETHPFMDFLKDDIKITINTDNMTVSNTTITKELEMLNKFCGLSIEDYKTIYLNSVEAAFTTKEAKKRLKKFVE
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: SOMA_PANPG
Sequence: MARVLVVLSVVVASLFFSQGATFENQRLFNNAVIRVQHLHQLAAKMMDDFEEALLPEERKQLSKIFPLSFCNSDSIEAPAGKDETQKSSVLKLLHTSYRLIESWEFPSKNLGNPNHISEKLADLKMGIGVLIEGCLDGQTSLDENDSLAPPFEDFYQTLSEGNLRKSFRLLSCFKKDMHKVETYLSVAKCRRSLDSNCTL
What is the function of this protein?
Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes.  Implicated as an osmoregulatory substance important for seawater adaptation.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PCXA_SYNR3
Sequence: MGLNDWLGTFAKAEGLDLSSDLEQAYEAALMIQGLELEYFNDRPVRTDVNLGLPQATQTQIFRRFRSALEICRALLSSIERQRAQLDSQELRQLQLIESVVRRYRSKDGQTLFQRPDPLPRSLLGVFDRVRNQLDPEAEANVVAGFRRRRDSTLVSLRILLLMILVPLLLQQISRTYVISPLVDRIAPDIPFLSYTKPRLQQSAVASLREYKAEIEFAALLEGEDSPSVEELRQKLTLKAAELKDEADSESTTAIKNVLADVVATIGFVLVCLFGRDEIRVLRGFFDEVVYGLSDNAKAFVIILFTDIFVGFHSPEGWTVLLQGISSHLGIPAEEQFIDLFIATFPVILATIFKYWIFRYLNRVSPSSVTTLRGMNGGG
What is the function of this protein?
Involved in light-induced Na(+)-dependent proton extrusion.  Also seems to be involved in CO(2) transport.
What are the official names of this protein?
Proton extrusion protein PcxA.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ODHI_CORJK
Sequence: MSDNTGVPEASVETTSVFRADLLKEMESGSQHDASPAGVEGLPEGSALLVVKRGPNAGSRFLLDQETTAAGRHPDSDIFLDDVTVSRRHAEFRRNGDQYEVVDVGSLNGTYVNREPKNSSVLSNGDEIQIGKFRLVFLNGSKEA
What is the function of this protein?
An essential component of the PknG signaling pathway.  When unphosphorylated, it inhibits the activity of 2-oxoglutarate dehydrogenase.  When phosphorylated it does not inhibit 2-oxoglutarate dehydrogenase (By similarity).
What are the official names of this protein?
Oxoglutarate dehydrogenase inhibitor.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKA_OCEIH
Sequence: MKTVDKSYMKELQTNHIHHNLSVAQLVEKILYRQEGILTSTGAVRATTGTYTGRSPEDKFTVKDEVSDQHVNWGKVNKPIQEEVFNQLLSKVISYLNEKQEIFKFQGFAGSDHTYRLPIQVINEYAWHNLFSRQLFITPTEEELNNHQAEFTVISAPGFKADPAIDGTNSETFILISFKKRIVLIGGTEYAGEIKKSIFSVMNYLLPQQDVLSMHCSANVGQEGDVALFFGLSGTGKTTLSADPYRKLIGDDEHGWSPNGVFNIEGGCYAKCINLSEEKEPQIYNAIRYGTVLENVILNDNSREPDYDDTSLTENTRAAYPLENIDNIINPSVAGHPNTIIFLTADASGTLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTEPLATFSACFGSPFLPLAPSKYAEMLGKKIDMFDTNVFLINTGWTGGSYGVGDRIKLSFTRAMVHSALEGELNSIETITDEIFGLQIPAHVPGVPDELLVPKQTWGNKEAYMKEAQTLALKFHENFKKFTLASETIKQAGPLYKG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YP034_YEAST
Sequence: MTTRKTVDSRLLEWQTTCKHPVINLTPEKVDKLYHLKLKSESKNISSNRLLPISLSSLQKKMEKLFIKDKSHSHKPSLPDPKVPTLRTYKDGGFFISGKGSMKLPDIESAIHKFLWKKYGKGLVYCYGCDPTGKKRHTEWFNVPVLELPSVLRLIDSYCLGGESR
What are the official names of this protein?
Uncharacterized protein YPL034W.
Protein: YBEY_LEGPL
Sequence: MTYHIDIQNATGKLLPLSEDEITKLASLALRDHKQDAELTVRLVDVEEMTYLNHTYRKKNKPTNVLAFPCSLPANIELECPLLGDVVICPEVLLAESAQFNKSLHAHWSLILIHGVLHLLGYDHIKDEEASIMQMLEAKLLAELGYANPYEVEENELE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_HELAH
Sequence: MLESMYYEFFFIFPKERELFESFLLDATDLALEESSLEDLKAFDDKETIGFISQSSWRYFATHGPLKEDLKEKLPHLDHFVILRSEKDLNSSLIPALESFCLSLQENLQNEFDFFYLSRNLASKDWLEAYKQAILPVQCGKFYIHPSWHQKPSHIATDFSIMIDPALAFGSGHHESTSMCLELLSNLDLKHKNALDVGCGSGILSIALKKQGVSTLVACDTDSLAIEETLKNFSLNQISLSTQDEIICGSTQKIQGHFDIIVANIVADVIKSLYSEFVRLCNHTLILSGILETHLNSVLQIYYNGFEILEQQQRNEWVALKLLKKQSIN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTER_MANSE
Sequence: MQLTSDPRRADRERRYKPPPSTTAPAEDLTTDYMNILGMVFSMCGLMMRLKWCAWTAVFCSSISFANSRVSDDTKQIVSSFMLSISAVVMSYLQNPSPMSPPWATLTT
What are the official names of this protein?
Protein Asterix.
What is the protein family that this protein belongs to?
Belongs to the Asterix family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PCH2_ORYSI
Sequence: MEVSFSAPPPPDAASAAAAAPSLVPAVSAAAVAATTVSCSPQPPTGSPSADDRILVSVEVLLHATSTARAEDVCAAVERMLEARSLSYVDGPVPIPNDDPFLLANVKRIQICDTDEWTENHKVLLFWQVRPVVHVFQLSEDGPGEEPGEDDTLSSFNEWALPAKEFDGLWESLLYEVGLKQRLLRYAASALLFTEKGVDPCLVSWNRIVLLHGPPGTGKTSLCKALAQKLSIRFKSRYSMCQLIEVNAHSLFSKWFSESGKLVAKLFQKIQEMVEEESNLVFVLIDEVESLAAARQAAISGSEPSDSIRVVNALLTQMDKLKSWPNVIILTTSNITTAIDIAFVDRADIKAYVGPPTLQARYEILRSCLQELLRVGILTHTQGGNSLCLLSYFSLMENQHCPEVADPHGSVHLSGLLHKAAEICEGLSGRTLRKLPFLAHASVANPSCCDASAFLHALIQTAQRELSESRG
What is the function of this protein?
Plays a key role in chromosome recombination during meiosis.
What are the official names of this protein?
Pachytene checkpoint protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. PCH2 subfamily.
Protein: CHMO_ATRHO
Sequence: MAASATTMLLKYPTTVCGIPNSSANNSTDPSNNIVQIPQTTTTNSPLLKFRTPNKPVNAVAAPAFPSVTTTTTTTPSSIQSLVKDFDPLVPAEDALTPPSSWYTEPAFYAHELDRIFYKGWQVAGYSDQVKEANQYFTGTLGNVEYLVCRDGEGKVHAFHNVCTHRASILACGSGKKSCFVCPYHGWVYGMNGSLTKASKATPEQSLNPDELGLVPLKVAVWGPFILISLDRSSREVGDVGSEWLGSCAEDVKAHAFDPNLQFINRSEFPIESNWKIFSDNYLDSSYHVPYAHKYYATELDFDTYQTDMVGNVTIQRVAGTSNNGFNRLGTQAFYAFAYPNFAVERYGPWMTTMHIVPLGPRKCKLVVDYYIEKSKLDDKDYIEKGIAINDNVQKEDVVLCESVQKGLETPAYRSGRYVMPIEKGIHHFHCWLHQVLK
What is the function of this protein?
Catalyzes the first step of the osmoprotectant glycine betaine synthesis.
What are the official names of this protein?
Choline monooxygenase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the choline monooxygenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: MUTL_SALPA
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEEIAPAPRHVPENRIAAGRNHFAVPAEPTTAREPATPRYSGGASGGNGGRQTAGGWPHAQPGYQKQQGEVYRALLQTPTTSPAPEAVAPALDGHSQSFGRVLTIVCGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQSPVCAQPLLIPLRLKVSADEKAALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: KATG1_VIBPA
Sequence: MTQQNAHSEGKCPVMHGSMTTNNRTEKNWWPKSLNLDILHQHDAKTNPMPSDFDYQEEVKKLDFSALKQDLIALMTDSQEWWPADWGHYGGLMIRMSWHAAGTYRIADGRGGAGTGNLRFAPLNSWPDNANLDKARRILWPIKKKYGNQLSWADLIAYAGTMAYESMGLKTFGFGFGREDIWHPEKDIYWGSEKEWLAPTNNPNSRYSGERDLENPLAAVMMGLIYVNPEGVDGQPDPLKTAHDVRVTFARMAMNDEETVALTAGGHTVGKAHGNGDAANLGPEPEGADIHDQGLGWLNKTTRGVGNNAVTSGIEGAWTSQPTQWDNGYFHLLLNYDWELKKSPAGAWQWEPIDIKEEDKPVDPENPNVRHNPIMTDADMAMKMDPEYRKISERFHSDPAYFADTFARAWFKLTHRDMGPKARYIGPDVPQEDLIWQDPVPNGNANYDIDAVKAKIAASGLSVSDMVTTAWDSARTFRQSDKRGGANGARVRLAPQKDWQGNEPERLARVLPVLENIAKDTGASVADVVVLAGNVGIEQAASAAGVNVTVPFLPGRGDATQEMTDVESFEVLEPLHDGYRNWLKQNYVVTPEEMLLDRTQLMGLTAAEMTVLVGGMRVLGTNHGGSKHGVFTDRVGQLTNDFFINLTDMKYTWEPVGENLYEIRSRRSKDVKWTATRVDLVFGSNSILRAYAELYAQDDNAGKFVEDFVAAWTKVMNADRF
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase 1, CP 1, Peroxidase/catalase 1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: PURT_SHEON
Sequence: MIGTPYTEGARRAMLLGCGELGKEVAIELQRLGVEVIGVDRYPNAPAMQIAHRSHVINMLDAKALRAVIELEKPHLVIPEIEAIATQTLVEMEAEGLNVVPTARATKLTMDREGIRRLAAETLGLPTSPYFFCDTETEFNQAISKIGVPCVVKPVMSSSGKGQSVIRNVAQSAKAWQYAQEGGRAGGGRVIVEGFIPFDYEITLLTISAVNGIHFCAPIGHRQEDGDYRESWQPQAMSADVLAKSQAIASKVVEALGGYGLFGVELFVKGSDVYFSEVSPRPHDTGLVTLISQDLSEFALHVRAILGLPIPNIHQHGPSASAVVLVEGKSKNIRYQGLAAALAAENTQLRLFAKPEIDGRRRLGVALARDKDIDSAVNKALDSAAKVQVIF
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: SPHK2_HUMAN
Sequence: MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPARGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTYPRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKAALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQLGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
What is the function of this protein?
Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions.  Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine.  Binds phosphoinositides (PubMed:19168031, PubMed:12954646).  In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219).  In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration.  The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514).  In nucleus, plays a role in epigenetic regulation of gene expression.  Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones.  Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656).  In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110).  In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity).  In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity).  Also involved in the regulation of glucose and lipid metabolism (By similarity).
What are the official names of this protein?
Sphingosine kinase 2, SK 2, SPK 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum. Mitochondrion inner membrane. Note=In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656). In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132). In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547). SUBCELLULAR LOCATION: [Isoform 2]: Lysosome membrane.
Protein: RECA_CUPMC
Sequence: MDDKKAGAGVSAEKQKALAAALSQIEKQFGKGSIMRLGDGEIEQDIQVVSTGSLGLDIALGVGGLPRGRVVEIYGPESSGKTTLTLQVVAEMQKLGGTCAFIDAEHALDVQYAGKLGVDVGNLLISQPDTGEQALEITDALVRSGSIDLIVIDSVAALVPKAEIEGEMGDSLPGLQARLMSQALRKLTGTIKRTNCLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGSIKKGDEVVGNETKVKVVKNKVSPPFREAFFDILYGQGISRQGEIIDLGVDAKIVEKAGAWYSYNGEKIGQGKDNAREYLRENPDIADEIENKVRLALGVAPLNTVAGAPAEVEG
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HY5_SOLLC
Sequence: MQEQATSSIAASSLPSSSERSSSSALHHELKEGMESDDEIRRVPEMGGEATGTTSASGRDGVSAAGQAQPSAGTQRKRGRSPADKENKRLKRLLRNRVSAQQARERKKAYLIDLEARVKELETKNAELEERLSTLQNENQMLRHILKNTTAGAQEGRK
What is the function of this protein?
Transcription factor that promotes photomorphogenesis in the light and positively regulates fruit pigmentation and fruit nutritional quality.  Probably acts downstream of the light receptor network and directly affects transcription of light-induced genes.
What are the official names of this protein?
Transcription factor HY5, LeHY5, tHY5.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.