PharMolix/UniProtQA huggingface dataset:
Protein: DRD1_HUMAN
Sequence: MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
What is the function of this protein?
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
What are the official names of this protein?
D(1A) dopamine receptor, Dopamine D1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
Protein: CYB_PYGBL
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLLRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTELVQWIWGGFSVDKATLTRFFAFHFLLPFIVAALVMVHLLFLHETGSNNPTGIPSDSDMIPFHPYYTIKDILGFLIMLTALSMLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIVPILHVSKQRSMMFRPLSQCLFWLLVAVLFTLTWIGGQPVEHPYIIIGQTASVLYFLIILIFMPTTSLMENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HIS2_BRUC2
Sequence: MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGVVSESADLLYHLAVVWNIAGVALEDVLQELQRRTAQTGLAEKASRPKG
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALT_ECO8A
Sequence: MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALITSPAGYGKTTLISQWAAGKNDIGWYSLDEGDNQQERFASYLIAAVQQATNGHCAICETMAQKRQYASLTSLFAQLFIELAEWHSPLYLVIDDYHLITNPVIHESMRFFIRHQPENLTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFTHQEAKQFFDCRLSSPIEAAESSRICDDVSGWATALQLIALSARQNTHSAHKSARRLAGINASHLSDYLVDEVLDNVDLATRHFLLKSAILRSMNDALITRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFCYHPLFGNFLRQRCQWELAAELPEIHRAAAESWMAQGFPSEAIHHALAAGDALMLRDILLNHAWSLFNHSELSLLEESLKALPWDSLLENPQLVLLQAWLMQSQHRYGEVNTLLARAEHEIKDIREGTMHAEFNALRAQVAINDGNPDEAERLAKLALEELPPGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMARQHDVWHYALWSLIQQSEILFAQGFLQTAWETQEKAFQLINEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIEVLSSYQPQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLGNGKYHSDWISNANKVRVIYWQMTGDKAAAANWLRHTAKPEFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQAGRKSDAQRVLLDALKLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPELEQHRAQRILREINQHHRHKFAHFDENFVERLLNHPEVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELEVAATTIKTHIRNLYQKLGVAHRQAAVQHAQKLLKMMGYGV
What is the function of this protein?
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides.  Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
What are the official names of this protein?
HTH-type transcriptional regulator MalT, ATP-dependent transcriptional activator MalT.
What is the protein family that this protein belongs to?
Belongs to the MalT family.
Protein: RS14_XANAC
Sequence: MAKTSMIHRDIKRAKLAKKFAGKRDALKKILSSQDASYEEKIDASTKLQKLPRDSSPSRHRNRCELSGRPRGVYRKFGLGRNMLRKATMNGDVPGLRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: TCPD_SCHPO
Sequence: MSKAATVPVAFQDREKPQEVRLSNIMAARSVADAIRTSLGPKGMDKMIQTGKGEVILTNDGATILKHLSVLHPAAKMLVDLSAAQDVEAGDGTTSVVILAGSMLACAEKLLKKGIHPTVIAESFQRAAGFTVDCMKENALAIELSDRESLLRAATTSLNSKIVSQYSNLLAPIAVDAVLKVIDPRVATNVDLKDIRIVKKLGGIIDDTELIPGLALTQTAVKSAGGPTRIEKANIALIQFQLSPPKPDMENQVVVNDYRQMDKILKEERQYLLNMCKKIKKAGANVILIQKSILRDAVNDLALHFLAKLKIMVIKDIERDEVEFICKSTGCKPIADIESFAEDKLGHADLVEETSSSGEKIVKFSGVKNAGKTVSILCRGANLLTLEEAERSLHDALCVIRCLVKQRALIAGGGSPEIEAAQRLLEHARQLEGREAICIRAFSEALEIIPVTLAENAGLNAIQVVTELRSRHANGEKTAGINVRKGIVTNILEENVLQPLLVNISAIQLAAETTKMIMKIDDITLAR
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
What are the official names of this protein?
T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHCG_HUMAN
Sequence: MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLSDMENEFYYRYPSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVVGVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGGSMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAISYHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAASASLEVYGKEGLVHSFDFQGFNGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPFWGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP
What is the function of this protein?
Ammonium transporter involved in the maintenance of acid-base homeostasis.  Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism.  Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+).  As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:11062476, PubMed:14761968, PubMed:15929723, PubMed:16477434, PubMed:16580862, PubMed:24077989).  May act as a CO2 channel providing for renal acid secretion (PubMed:24077989).
What are the official names of this protein?
Ammonium transporter Rh type C, Rh glycoprotein kidney, Rhesus blood group family type C glycoprotein, Rh family type C glycoprotein, Rh type C glycoprotein, Tumor-related protein DRC2.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=Also detected at the basolateral membrane and in subapical vesicles.
Protein: MDM12_ARTOC
Sequence: MSIDINWEAATSGPDGEKLAERIRSFIHDKFQQIALPRFIRSVEVNSFDFGTVSPELQVRDICDPFNDFYEEDEDGEDLSESSVSDEPAPSSQGLSQSTPNGDAGSSNSSSNGDGGGNTNSRVGYFQRRYPSGEYAGDFPQPLMSPINLGESFNPYLFPRAGTPGIPGGTSNLGYYNMPRGGLSGTQTPLASVASVARGGPLSLAEGWPPPARQRERARSSDADVDSPQSRSRPSTSSTRQRTSTDGGTPHDSAEIPESESVITGHLDSALPTRRMREQKPDDFQVLCRLQYSGNMRLSITAQILLDYPMPSFVGLPLKLNITGFTFDGVAVVAYIRKRIHVCFLSPEDADTLLGADDKMASTEGYHDHHNHHHSGNTNTTGSRRSNDSLLREIRVESEIGRKESGKQVLKNVGKVEKFVLEQVRRIFEEEFVYPSFWTFLV
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: PYRG_MYCPA
Sequence: MRKHPQTATKHLFVSGGVASSLGKGLTASSLGQLLTARGLYVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKGRILAMAQPDAQGNRPDVVITEIGGTVGDIESQPFLEAARQVRHDLGRENVFFLHVSLVPYLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPEALKNKIALMCDVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTEWDDLLRRVHEPHETVRIALVGKYVELSDAYLSVTEALRAGGFFHHAKVEMVWVASDDCESASGAAAALGEVHGVLIPGGFGIRGIEGKIGAIHYARTRGLPVLGLCLGLQCIVIEAARAAGLAGANSAEFDPDTPDPVISTMADQVDIVAGAADLGGTMRLGAYPAVLEEDSIVARAYGTTQVSERHRHRYEVNNAYRDKIAESGLRFSGTSPDGHLVEFVEYPPDVHPFIVGTQAHPELKSRPTRPHPLFVAFVGAAMDYKAGELLPVEIPEQSSNGIQHRDSAARPIPEPAARG
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: TILS_CHLT2
Sequence: MITRLFENDKQLEGFFSSLDKKKKYLLALSGGSDSLFLMYLLKSRAIFFTAVHVDYGWRETSYQEASDLAALCEQEQIPFILDRPEATDPMDSRDIENAARRYRYELFYRLCKEKCFSGVFLGHHADDQAETILKRVFEGAHLGNLKGMSAQVMYRDVALLRPLLHIPKHKIVEALDSHQVQYVQDITNCNERFLRARMRERLFPYLQDVFGKNIRDPLLSLAGDSAELREYLDQQTAPFLLRVVDNERGKLLPIEQELLKTPFLAKWVCKQFFLNEGLVASKSFLQTVYDHLMTGSTARLRLRNRTVLVKARGVIIESIY
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_NATTJ
Sequence: MSRRHRTFPVKVGSVTIGGTAPVTIQSMTNTDTKDTEKTLAQIKDLVEAGCQLVRVAIPDEESVNSFKTLTQFSPVPLIADIHFSYQLAIKAIEAGASKIRINPGNIGSRQRVAKVVEKAKTHNVPIRVGINSGSVEKNLLQKYGGPTPSALVESAVNNVMMLSEMGFGDVVVSIKASDVNTTVKANQEFATRLPNPLHLGITEAGTIKQGTIKSSVGIGTLLSHGIGDTLRVSLSGSPIEEVSVARGILSSLNLAEGPRIVSCPTCARSNISVEDLASTVEDRLKDLNTSLTVAVMGCEVNGPGEAKEADIGIAGSKEYGVLFKKGKIIDRVPKNQLLEVLSRAIDEYIDEIHSK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: NANH_SALTY
Sequence: MTVEKSVVFKAEGEHFTDQKGNTIVGSGSGGTTKYFRIPAMCTTSKGTIVVFADARHNTASDQSFIDTAAARSTDGGKTWNKKIAIYNDRVNSKLSRVMDPTCIVANIQGRETILVMVGKWNNNDKTWGAYRDKAPDTDWDLVLYKSTDDGVTFSKVETNIHDIVTKNGTISAMLGGVGSGLQLNDGKLVFPVQMVRTKNITTVLNTSFIYSTDGITWSLPSGYCEGFGSENNIIEFNASLVNNIRNSGLRRSFETKDFGKTWTEFPPMDKKVDNRNHGVQGSTITIPSGNKLVAAHSSAQNKNNDYTRSDISLYAHNLYSGEVKLIDDFYPKVGNASGAGYSCLSYRKNVDKETLYVVYEANGSIEFQDLSRHLPVIKSYN
What is the function of this protein?
Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources.  Sialidases have been suggested to be pathogenic factors in microbial infections.
What are the official names of this protein?
Sialidase, N-acylneuraminate glycohydrolase, Neuraminidase, NANase, STNA.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 33 family.
Protein: RS9_BURPS
Sequence: MIGNWNYGTGRRKSAVARVFIKAGKGDIVVNGKPISDYFSRETSLMIVRQPLELTNHAQTFDIKVNVSGGGETGQAGAVRHGITRALIDYDATLKPALSKAGFVTRDAREVERKKVGLHKARRAKQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: ROCA_STAA8
Sequence: MVVEFKNEPGYDFSVQENVDMFKKALKDVEKELGQDIPLVINGEKIFKDDKIKSINPADTSQVIANASKATKQDVEDAFKAANEAYKSWKTWSANDRAELMLRVSAIIRRRKAEIAAIMVYEAGKPWDEAVGDAAEGIDFIEYYARSMMDLAQGKPVLDREGEHNKYFYKSIGTGVTIPPWNFPFAIMAGTTLAPVVAGNTVLLKPAEDTPYIAYKLMEILEEAGLPKGVVNFVPGDPKEIGDYLVDHKDTHFVTFTGSRATGTRIYERSAVVQEGQNFLKRVIAEMGGKDAIVVDENIDTDMAAEAIVTSAFGFSGQKCSACSRAIVHKDVYDEVLEKSIKLTKELTLGNTVDNTYMGPVINKKQFDKIKNYIEIGKEEGKLEQGGGTDDSKGYFVEPTIISGLKSKDRIMQEEIFGPVVGFVKVNDFDEAIEVANDTDYGLTGAVITNNREHWIKAVNEFDVGNLYLNRGCTSAVVGYHPFGGFKMSGTDAKTGSPDYLLHFLEQKVVSEMF
What are the official names of this protein?
1-pyrroline-5-carboxylate dehydrogenase, P5C dehydrogenase, L-glutamate gamma-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. RocA subfamily.
Protein: VPI_HAEIN
Sequence: MKAEKTSLAVLTAQLTSPDGWQQLLPKGEFRSRDGSPTDVAHWFIDGTIAQNLIHKARQLNQDLLVDYDHETILKAKKGIDAGNVVAAGWFNADEIQWFDDETRQGLYIKPRWTPKAYQQIKDGEFAFLSAVFPYDENGTPLELRMAALTNDPGITGMQRLAVLSATLNPQENVKMPESLRKLLAKLGVEIAEGVELTEEQANTALNALETLQTDKTKADEQVATLSAKNTEVDLSQYVPKATYDAVMSQVAVLSAKTDDVEIDNHISKARNEGRAVEAEVEYLKQFGKQQGVAALSAMLEKRPQIAVLSAQQTQTTKVEKPVEKGTAVLSAADKEAAKLLGISEQDYAKELEAK
What is the function of this protein?
Potential protease involved in virion morphogenesis.
What are the official names of this protein?
Mu-like prophage FluMu I protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase U35 family.
Protein: GRDA_PEPLI
Sequence: MSLFDGKKVIIIGDRDGIPGPAMAECLKGINVEVVYSATECFVUTAAGAMDLENQNWVKNFTDQYGAENIIVLVGAAEAESAGLAAETVTAGDPTFAGPLAGVQLGLRVFHAVEPEFKGAVDSAIYDEQIGMMEMVLDVDSIIEEMKSIRADYCKFND
What is the function of this protein?
In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate.  Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine.  By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state.  Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.
What are the official names of this protein?
Glycine/sarcosine/betaine reductase complex component A, Selenoprotein PA, Thioredoxin reductase complex selenoprotein A.
What is the protein family that this protein belongs to?
Belongs to the GrdA family.
Protein: THIO1_STRCO
Sequence: MAGTLKHVTDDSFEQDVLKNDKPVLVDFWAAWCGPCRQIAPSLEAIAAEYGDKIEIVKLNIDENPGTAAKYGVMSIPTLNVYQGGEVAKTIVGAKPKAAIVRDLEDFIAD
What is the function of this protein?
Component of the thioredoxin-thioredoxin reductase system.  Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.  Stimulates complex formation between sigma factor SigR and its cognate anti-sigma factor RsrA probably by reducing RsrA.
What are the official names of this protein?
Thioredoxin 1, Trx-1.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INP4A_MOUSE
Sequence: MTAREHSPRHGARARAMQRASTIDVAADMVGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQIKLSVYDVKDRSQGTMYLLGSGTFVVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQQPPVTRFLDTVNGRMVLPVDESLTEALGIRSKYAFLRKDSLLKAVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYKGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDVVTIGAPAAHCQGFKSGGLRKKLHKFEEAKKHSFEECCTSSSGQSIIYIPQDITRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWAGRSSRSSLQVDWHEEEWQKVWLNVDKSLECIIQRVDKLLQKDRLHGEGCEDAFPCSSTCSSKKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKAAMVFLLMQDSAPTIASYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDGGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSNASSDMLPVITGNRDGFNVRIPLPGPLVDSFPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEGINGESLVRVNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEVCRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
What is the function of this protein?
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PubMed:20463662).  Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity).  Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:11087841, PubMed:19325558).  May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (PubMed:20463662).
What are the official names of this protein?
Inositol polyphosphate-4-phosphatase type I A, Inositol polyphosphate 4-phosphatase type I, Inositol polyphosphate 4-phosphatase-1, 4-Ptase-1, Type I inositol 3,4-bisphosphate 4-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
What are the subcellular locations of this protein?
Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Postsynaptic density. Note=Translocates to the plasma membrane upon EGF stimulation (By similarity). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (By similarity).
Protein: TCPH_BOVIN
Sequence: MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDLLQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINTEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDASPAAGRGRGRGRLH
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.  The TRiC complex plays a role in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit eta, TCP-1-eta, CCT-eta.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y090_AFV2P
Sequence: MGLTGLGKIVSQIIRQIAHGLEYVGDKVSHYIRLALHYLYEFAKAFYHYLGKLYDTFQRDPIRFLQFAGSLAIMTYYGVL
What are the official names of this protein?
Uncharacterized protein ORF90.
Protein: CSN7A_NEUCR
Sequence: MEQTKALNALEPFIVLSKSATSPRAAADLVTRVTSAPNTFIFTELLQTPQIQSLEYSHEFSSYLTLLQIFSHGTYADYIANASALPALNDDQKLKLRQLSLLTLVANDGSNVPLDYDAMQRENNQAQPPNQSYASLTRRLELSSARELEELVISAIYAGLIEGQLDPANEMVQINSVAALRDVPARGVNGLLSSLQGWAGRCQATLQELEATMANLRDEADRRATEEQEWNNKMSQLLEDEQKGAVPSSSSSSLPFSWFNNTRGGGGGGDGAGAGGSFRGSGYSRGGGLSQGYRSSQRGSHQQHQNQSRQQQNHHHHHQSNQSGTNSLLTSGGGSYLSFREGPSAVSPSAAAGLMGSSTSFAALGGMETGSGSGSGPLGKRGSSDMDDSEEDIDDDTMDLDDEGDETKRGSKRKLTA
What is the function of this protein?
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity).  The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex.
What are the official names of this protein?
COP9 signalosome complex subunit 7a, CSN complex subunit 7a.
What is the protein family that this protein belongs to?
Belongs to the CSN7/EIF3M family. CSN7 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL27_XANOR
Sequence: MAHKKGVGSSRNGRDSNPKYLGVKIFGGQAIDAGNIIVRQRGTQFHPGAGVGLGRDHTLFALVDGKVEFSVKGVKKRRTVSVVAEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: ATPD_HAES1
Sequence: MSELTTIARPYAKAVFDFAVEQSEKDKSTVEKWANMLEFLSELIRHDKVQTYLTSTSSTFKLADTVISICSEQLDQYGQNLVRLMAENKRLSVLPAVFNEFKSYVEEYKSLSQVEVISAQQLNDVQQQKIITAMEKRLARKVILNCRIDSSLIAGAIIRTNDFVIDGSCRGQINRLANELRL
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CLPP_LIMRD
Sequence: MNLVPTVIEQSSRGERAYDIYSRLLKDRIIMLSGPIEDEMANSIVAQLLFLDAQDSTKDIYLYINSPGGVVTSGMAIYDTMNFIKADVQTIVIGMAASMASVLVSSGAKGKRFGLPHSQVLIHQPSGGAQGQQTEIEIAATEILKTRKMLNGILAKNSGQPIEKIQADTERDHYLTAQEAVDYGLLDGVMENNSKLK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPAB4_MOUSE
Sequence: MDAQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
What is the function of this protein?
Factor that activates expression from a metal response element of the mouse metallothionein-I gene.
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC4, RNA polymerases I, II, and III subunit ABC4, DNA-directed RNA polymerase II subunit K, Metallothionein-I gene transcription activator, RPB10alpha.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.