PharMolix/UniProtQA huggingface dataset:
Protein: DDL_BORRA
Sequence: MKKNLMLIFGGVSFEHEISLRSAYGIYSSLLKLDKYNVFSIFVDKVTGIWYLLDSVPSSAELIKRHTTSIVNFIPGCGIFVNNKSLEIDVIFPIIHGRTGEDGAIQGFVKMMDIPCVGAGILGSAISINKYFCKVLLKSFNIPVVSFIGFKKDDYILNKEGIKEDINNKLNYPVIVKPSVLGSSIGINVAYNVSQIEKYIEEAFEYDLTVVVEKFIKAREIECAVIGNDQIKIFTPGEIVVQDFIFYDYDAKYSTVPGDSIVFNIPAHLDMKHLLDIKEYAFLTYKYLELRGMARIDFLISKDTNLLYVNEVNTIPGFTDISMFAKMCEHDGLSYESLVDKLITLAFESYKKRKDKIDFTRLES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_NEIMF
Sequence: MLKFTLHKKDGYARRGTLELNHGKIETPVFMPVGTYGSVKAMNPQNLHDIKAQIILGNTYHLWLRPGLEVVEQFGGLHGFIGWDKPILTDSGGFQVFSLSDMRKLTEEGCTFKSPINGDKLFLSPEISMKIQTVLNSDIAMQLDECTPGEATREQAKKSLQMSLRWAERSKKAFEDLKNPNALFGIVQGAMYEDLREESLRGLEQFDFPGLAVGGLSVGEPKPEMYRMLRAVGPILPEHKPHYLMGVGTPEDLVYGVAHGIDMFDCVMPTRNARNGWLFTRFGDLKIKNAKHKLDKRPIDESCTCYACQNFSRAYLHHLHRTGEILGAQLNTIHNLHFYQVIMAEMREAVEQGKFADWQARFHENRARGTD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PUR5_BURCM
Sequence: MNPPKSAPDAQGLSYRDAGVDIDAGDALIDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYKEPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVVKGIAHGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGSTIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADTLMAPTRIYVKPLLALMQKLPVKGMAHITGGGLVENIPRVLREGLTAELDQNAWPLPPLFKWLQEHGGVADAEMHRVFNCGIGMAVIVSAADADAAIADLTAAGEQVWKIGTVRASREGEAQTVVV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBPL2_XENTR
Sequence: MDGESSLERYLDQCDAEDVLASSAHMYTPMTPYDDLAIQPLPGTSYSSALEQSKELSTDFSSVDLSFLPDDLNQENEDQQEQQTSSQSLEQDSGICLDASNLSQPFTPSECRDASQDSTNLCPMPITPMTPMTPMTPVAESSGIVPQLQNIVSTVNLACKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVRFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFKKTT
What is the function of this protein?
TATA box-binding transcription factor.  Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis.  Required for gastrulation.  Regulates a large subset of genes that are ventrally expressed (By similarity).  Binds to a subset of promoters.
What are the official names of this protein?
TATA box-binding protein-like 2, TBP-like 2, xTBPL2, TATA box-binding protein-related factor 3, TBP-related factor 3.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IF2_CAMJJ
Sequence: MAKIRIHEIAKELGYDSKEIIEKANELGLGIKTASNAVEPEIAAAIYEYIQTREIPEAFKKNIKTPTAKKPKKENIKEQEKLNESEKKEPKKEEKLKQEVKKEELKIEKENAKEEEKQEIIDAHKPQSLASATLAKRRGLVIVKKKKDEEEIQVKKEEVKNSNDISINNEERLSLKTMFSNADESLKKKKKEKKSFVASKKESTEKMNFLDEHDFGDISLDDEDEVVLPDFSVKEQEKPQNINKKQPNFIRQAVGNSAGFGLEGGIQRRSRKKPSKKIEKKEVEEVGSVAISKEIRVYEFADKIGKSTSEVISKLFMLGMMTTKNDFLDEDAIEILAAEFGIEINIINEADEFDYVKDYEEETDEKDLVTRAPVITIMGHVDHGKTSLLDYIRKSRVASGEAGGITQHVGAYMVEKNGRKITFIDTPGHEAFTAMRARGASITDIVIIVVAADDGVKPQTKEAINHAKAAGVPIIIAINKMDKEAANPDMVKTQLAEMEIMPVEWGGSYEFVGVSAKTGMGIEDLLEIVLLQADILELKANPKSFAKASIIESSVQKGRGAAATIIVQNGTLTVGSTVVAGEAYGKVRAMSDDQGKALKEIKPGECGVIVGLSEVADAGEILIAVKTDKEAREYANKRHEYNRQKELSKSTKVSIDELGAKIKEGNLKALPVILKADVQGSLEALKASLEKLRNDEIKVNIIHSGVGGITQSDIELASASENSIVLGFNIRPTGEVKERSKDKGVEIKTYNVIYNLLDDVKALLGGMMSPIISEEQLGQAEIRQVINVPKIGQIAGCMVTEGVINRGAKIRLIRDGVVVYEGNVSSLKRFKDDAKEVAKGYECGVGIEGCDDMRVGDYIESYKEVEEQASL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLD_SHEB2
Sequence: MNEQLINRTMAFAGILQAIAQVQHLARHGELDNAELAASLNTILVTNPDNTADVYQDKIVLQKGYKLILNQLGDSSQKDVEITRYLVGVLALERKLVRSNSGLGMLAERINQVNRQLHHFAITDEQVIANLASIYSDIISNLGPKIQISGNPVCLQRPIIQQKIRALLLAAMRSAVLWRQLGGKRRHLVFARKAIVDTAKKSLTL
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GPGS_MYCPA
Sequence: MTTSDLVAGELAGDGLRDTRPGDTWLADRSWNRPGWTVAELEAAKAGRTISVVLPALDEEDTIGSVIDSISPLVDGLVDELIVLDSGSTDDTEIRAVAAGARVVSREQALPEVPIRPGKGEALWRSLAASRGDIVVFVDSDLINPHPMFVPWLVGPLLTGDGVHLVKSFYRRPLNVGDAGGGAGATGGGRVTELVARPLLAALRPELGCILQPLGGEYAATRELLTSVPFAPGYGVEIGLLVDTFDRLGLDAIAQVNLGVREHRNRPLAELGAMSRQVIATLLSRCGIPDSGVGLTQFVADGPEGQSYTQHTWPVSLADRPPMQAIRPR
What is the function of this protein?
Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs).  Catalyzes the transfer of the glucose moiety from UDP-alpha-D-glucose (UDP-Glc) to the position 2 of 3-phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG).  To a lesser extent can also use GDP-Glc but not UDP-Gal or UDP-GlcNAc as the sugar donor.
What are the official names of this protein?
Glucosyl-3-phosphoglycerate synthase, GpgS.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: SCAM4_HUMAN
Sequence: MSEKENNFPPLPKFIPVKPCFYQNFSDEIPVEHQVLVKRIYRLWMFYCATLGVNLIACLAWWIGGGSGTNFGLAFVWLLLFTPCGYVCWFRPVYKAFRADSSFNFMAFFFIFGAQFVLTVIQAIGFSGWGACGWLSAIGFFQYSPGAAVVMLLPAIMFSVSAAMMAIAIMKVHRIYRGAGGSFQKAQTEWNTGTWRNPPSREAQYNNFSGNSLPEYPTVPSYPGSGQWP
What is the function of this protein?
Probably involved in membrane protein trafficking.
What are the official names of this protein?
Secretory carrier-associated membrane protein 4, Secretory carrier membrane protein 4.
What is the protein family that this protein belongs to?
Belongs to the SCAMP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AFFL_DROWI
Sequence: MAQQQQQQQHHHHLQHQQQQQQQQQLQHHSNLLLLQQQQQQQQQQQQQQQQLLQQEQQLQQYDNNLYSQNYNMEEYERRRRREREKYERQQGIQSDDRETSLFSEPRRLTEGDAEITAALGEFGDARNYINQYTVGISRHAPGGGSGNGSIGNNPRLQAPMIQQQVSSSISSSASVASSLLPPGLGQTQQQQQQQQQQQQPRPPTYLKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPKLNSNSSSITNNAAASSSSSLLGPPISTQVPNGREKSFLGPPTTGTALHNGGGRFAQPVSNKRPGVGIQPPPPQEKDVRSMLSEMKNHFQVTPLNPIAATPQAPTRENYNLNAPNKFKYAFDIVDPIMPLLNSPPSVTPSSLITPIAPMTSPIAPLLTTPPQASQLPLGSGSGNGAAISATSLSTTTAAAAAAAAVAGVAATVAATVAPIQQLPPTPPKAMSVTPPTAKPLKIEKNPILEKQDSCLENDLELSESEDERKKDGRSPGSSSNGSESDSTESGSESSSKGEHNHHHHHQQQQQQTQQQQLHGHHPQSHHHQQFLQQQLQRQQQQQQQQQQLTANGGKKKYSQTIIASGANTITGLLTSSGGLGSSSGNNSSGGGGGSGNGGTTSSSSGGSMGGSGGSSSSGGASGGGGGGGGSGSSSGIGSGSSSNKTPSPTDSNKWNLSRFFHKPTSQTSSESVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKIHHDDHLMDIDECDEDDDDVDEQHQQLRYGAGLSVTPVAVKKEEDLGLLTAAAIPKSQIKRESETQISHQRLSESATSGSSSSSCSSSDSAASASEVVPMPGPGETLQIPGVPAAITSVMRVPPINNMQKSQSMSVTVTPIAPLPASPKPRQKKPRKKKMMSVLTPPLLDSSDEDEPSTKHSSLVVAQAQAAVVPPPSTNSTTTSATTTKKGRGRPRKQQQQQSAGSGNLSSASAGSSSQAKGPTLTAAKKTLVKASASSSTSNTNSSSVLPRKREHSSQSSSNGNTPTKKMSSIPMMPAAAASAAATLLQPPAVAAANAVAASSSSSDEESSSSSCSTSKSSSSSSSSDDTETQKTNCRIVKLNKTVPVTAAMAPLAKRSSYHRRSGSSSPTSSSSETDKPNSNSHNNLGIAAISNSNSNSNNNVIVNNNLQQQAMPQQSPYKVPLSGGSQQLSSSDSSSSSSGSSSSSGDEDDAKREKNRERKPKSDKNKISTLTRIFNNKEGGAKKQGQVVIIDQSEEQLQQQQQQQQQVQIRDPLPPPSLLSQSGGVKQRMTPTQQQQLGAGLASPARTTTPLLTSLICKIDLSKLSRERILRLKKLAPSSSNQQNGHLTPNGHVVQGGSSPAGLSKVKHEHHQLHHHSQQAHSHPVKPEPELDSLYETKFRPTNVKQEFQLKQERDRDRNRERDQQQQPPPRRRKRSSSSSSSPYKEKKRKKEKTDPMLTNAKDQMLQINPMLLPSNNHERLSYDKYQLLQEDAAAAAAAAAAVAVVNSSNGQKLFQSSIGGGTGATAVGPLSIMAPSTCSEAVQTTPPTSVTGAGAPASLVSQPPPPPRLIYRSYFDREEEHPSDDLRKSKQFLQEAVQRKHAADSERDSFNQVTLYLEAVAYFLLTADAMERCSSETATWTMYKDTLSLIKFISSKFRPYQQSANCQQETHNKVAILSLRCQSLISLKLFKLRRVNCRAIINSLTDFFRNGRGDIVNGNTPSSISPSNSVGSQGSGSNTPPGKIVPQDIHNQLCKQNEYLTYVNSAHELWDQADRLVRTGNHLDFFRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSHPTHQSQ
What is the function of this protein?
Has a role in transcriptional regulation.  Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth.  Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate.  Required specifically for the microtubule-based basal transport of lipid droplets.  Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye.  Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).
What are the official names of this protein?
AF4/FMR2 family member lilli, Protein lilliputian.
What is the protein family that this protein belongs to?
Belongs to the AF4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: H2A20_CYRHA
Sequence: MKVTLIAILTCATVLVLHTTAAEELEAESQLMEVGMPDTELAAVDEERLFECSVSCEIEKEGNKDCKKKKCKGGWKCKFNMCVKV
What is the function of this protein?
Neurotoxin active on both insects and mammals.
What are the official names of this protein?
U4-theraphotoxin-Hhn1a, U4-TRTX-Hhn1a, Hainantoxin-II.20, HNTX-II.20, Peptide F8-20.15.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LIP1_STAAW
Sequence: MKSQNKYSIRKFSVGASSILIATLLFLSGGQAQAAEKQVNMGNSQEDTVTAQSIGDQQTRENANYQRENGVDEQQHTENLTKNLHNDKTISEENHRKTDDLNKDQLKDDKKSSLNNKNIQRDTTKNNNANPSDVNQGLEQAINDGKQSKVASQQQSKEADNSQDSNANNNLPSQSRIKEAPSLNKLDQTSQREIVNETEIEKVQPQQNNQANDKITNYNFNNEQEVKPQKDEKTLSVSDLKNNQKSPVEPTKDNDKKNGLNLLKSSAVATLPNKGTKELTAKAKDDQTNKVAKQGQYKNQDPIVLVHGFNGFTDDINPSVLAHYWGGNKMNIRQDLEENGYKAYEASISAFGSNYDRAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYEGIYKDWKPGQKVHLVGHSMGGQTIRQLEELLRNGNREEIEYQKKHGGEISPLFKGNHDNMISSITTLGTPHNGTHASDLAGNEALVRQIVFDIGKMFGNKNSRVDFGLAQWGLKQKPNESYIDYVKRVKQSNLWKSKDNGFYDLTREGATDLNRKTSLNPNIVYKTYTGEATHKALNSDRQKADLNMFFPFVITGNLIGKATEKEWRENDGLVSVISSQHPFNQAYTKATDKIQKGIWQVTPTKHDWDHVDFVGQDSSDTVRTREELQDFWHHLADDLVKTEKLTDTKQA
What are the official names of this protein?
Lipase 1, Glycerol ester hydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: TOMT_HUMAN
Sequence: MGTPWRKRKGIAGPGLPDLSCALVLQPRAQVGTMSPAIALAFLPLVVTLLVRYRHYFRLLVRTVLLRSLRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHMVELIVGSSEDVIPCLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATVLADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG
What is the function of this protein?
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity).  Required for auditory function (PubMed:18794526).  Component of the cochlear hair cell's mechanotransduction (MET) machinery.  Involved in the assembly of the asymmetric tip-link MET complex.  Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells.  The function in MET is independent of the enzymatic activity (By similarity).
What are the official names of this protein?
Transmembrane O-methyltransferase, Catechol O-methyltransferase 2, Protein LRTOMT2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
What are the subcellular locations of this protein?
[Isoform 1]: Membrane; Single-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Endoplasmic reticulum. Note=Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia (PubMed:28504928). Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern (By similarity).
Protein: NUOK_METPP
Sequence: MSITLGHYLSLGAMLFALSVIGIFLNRKNLIVLLMAIELMLLAVNLNFVAFSHYLGDMAGQVFVFFILTVAAAESAIGLAILVVLFRNRSTINVDELDALKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CDC37_DROVI
Sequence: MVDYSKWKNIEISDDEDETHPNIDTPSLFRWRHQARVERMAESEKEKEELKKKRQSYQARLINVKELISKKEGDEVALKKELEKIENEGKELDRQENELLKREKKTPWNVDTISKPGFEKTVINKKPPRKAAEDLTEEEREQRMKQFVKENEKLCKQYGMLRKYDDSKRFLQEHLDLVCEETANYLVIWSINLEMEEKHDLMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSKIQQCVPEYRQQFESEIEGFKERIQKRAQEKLQEAMAQLEEEEKQERMGPGGLDPADVFESLPEELKACFESRDIELLQKTIATMPVDQAKYHMKRCVDSGLWVPNAADVQLGNDETEAKDDETTTATNETPTEKENSKSQNEKSADAAKEEPLYAGVSTDDVD
What is the function of this protein?
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
What are the official names of this protein?
Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit.
What is the protein family that this protein belongs to?
Belongs to the CDC37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGE_SHIB3
Sequence: MNLQHHFLIAMPALQDPIFRRSVVYICEHNTNGAMGIIVNKPLENLKIEGILEKLKITPEPRDESIRLDKPVMLGGPLAEDRGFILHTPPSNFASSIRISDNTVMTTSRDVLETLGTDKQPSDVLVALGYASWEKGQLEQEILDNAWLTAPADLNILFKTPIADRWREAAKLIGVDILTMPGVAGHA
What are the official names of this protein?
UPF0301 protein YqgE.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: P5CS_MOUSE
Sequence: MLRHMHRSGVQPFRQRLLPWVQSIAVPRSNRVQPSAIRHVRSWSNIPFITVPLSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAEGRLASPLLKRLSLSTSKLNSLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSSHTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGQDHVVSDFSEHGSLKYLHENLPVPQRNFS
What is the function of this protein?
Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.
What are the official names of this protein?
Delta-1-pyrroline-5-carboxylate synthase, P5CS, Aldehyde dehydrogenase family 18 member A1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: PLSY_CHLP8
Sequence: MLTFLAIITVAYLIGSIPTSIIAGRMLKGIDIREFGSGNAGGTNAFRVLGWKAGLAVTLIDIAKGTIAAVPVVAFFKAHPLGAFPDMNEIALNLIAGMSAVIGHVFTVFAGFKGGKGVSTAAGMLIGIAPISMLMVIGVFILAITLTRYVSVGSILAAIAFPLIIAIRKYLFDLGTGLDYHFFGKWLVHDSLDYHLLIFGGIVAAAIIYTHRANIKRLFSGTENRLTFGRRS
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACKA_METSB
Sequence: MSRCVITLNAGSSSIKFALFREGLTQEGSAKELTPMAIGLAEMVGEERRITVHDGAGAKIYEVKRTEHVDAPFHAEALRRILAWRQSAFPDAEVVAAGHRVVHGGVHYSAPVIVTDEVLKYLHTLIPLAPLHEPYNIAGILGAREAWPHVEQVACFDTAFHRTHPFVNDVFALPRRFYDEGVRRYGFHGLSYEYIVRRLREIAPLHAAGRVVVAHLGNGASMCAIRDGLSVASSMGFTALDGLPMGTRCGQLDPGVVLYLMQEKKMSAAEITDLLYRESGLKGLSGLSHDMRELEAADTLEAQQAIEYFVFRIRRELGGLAAVLKGIDAIVFCGGIGENSRHVRERVLEGMEWIGVELDRSANSANAEVISSERSRTRVFVIPTDEEGMIARHTLALLDQMAAA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NULLO_DROME
Sequence: MGSTHSAEKVKSVEDSTSPANPGIFCTPLPGFISNIQRLVLRKLSISARKQKRLNKRSKHLLRPMPRCSSFGSCGTLLTPTKKSASNIADRRYAQWKCSFEHLAQKQPRLHDISEAMTGQTTPRGFPSHTDPKRCLMVMDSSSPESPLYDMVGGQKVRRRLSLRSHALVRRPSARQKAEQAKLDAQFQRDLRDLEDYYGGFHFAQRRERLVKV
What is the function of this protein?
Actin-myosin network stability during cellularization.  Might be involved in increasing actin-actin interactions or membrane-to-cytoskeleton attachments.  nullo together with Sry-a and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
What are the official names of this protein?
Protein nullo.
Protein: GLNA_BOVIN
Sequence: MATSASSHLNKGIKQVYMALPQGDKVQAMYIWIDGTGEGLRCKTRTLDSEPKCIEELPEWNFDGSSTFQSEGSNSDMYLVPAAMFRDPFRKDPNKLVFCEVFKYNRKPAETNLRHTCKRIMDMVSNQRPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGIKIGGTNAEVMPAQWEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPFAVTEALIRTCLLNETGDEPFQYKN
What is the function of this protein?
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity).  Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity).  Essential for proliferation of fetal skin fibroblasts.  Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation.  May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity).  Plays a role in ribosomal 40S subunit biogenesis (By similarity).
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Palmitoyltransferase GLUL.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Microsome. Mitochondrion. Cell membrane; Lipid-anchor. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane.
Protein: RESA_PLAFF
Sequence: MRPFHAYSWIFSQQYMGTKNVKEKNPTIYSFDDEEKRNENKSFLKVLCSKRGVLPIIGILYIILNGNLGYNGSSSSGVQFTDRCSRNLYGETLPVNPYADSENPIVVSQVFGLPFEKPTFTLESPPDIDHTNILGFNEKFMTDVNRYRYSNNYEAIPHISEFNPLIVDKVLFDYNEKVDNLGRSGGDIIKKMQTLWDEIMDINKRKYDSLKEKLQKTYSQYKVQYDMPKEAYESKWTQCIKLIDQGGENLEERLNSQFKNWYRQKYLNLEEYRRLTVLNQIAWKALSNQIQYSCRKIMNSDISSFKHINELKSLEHRAAKAAEAEMKKRAQKPKKKKSRRGWLCCGGGDIETVEPQQEEPVQTVQEQQVNEYGDILPSLRASITNSAINYYDTVKDGVYLDHETSDALYTDEDLLFDLEKQKYMDMLDTSEEESVEENEEEHTVDDEHVEEHTADDEHVEEPTVADDEHVEEPTVADEHVEEPTVAEEHVEEPTVAEEHVEEPASDVQQTSEAAPTIEIPDTLYYDILGVGVNADMNEITERYFKLAENYYPYQRSGSTVFHNFRKVNEAYQVLGDIDKKRWYNKYGYDGIKQVNFMNPSIFYLLSSLEKFKDFTGTPQIVTLLRFFFEKRLSMNDLENKSEHLLKFMEQYQKEREAHVSEYLLNILQPCIAGDSKWNVPIITKLEGLKGSRFDIPILESLRWIFKHVAKTHLKKSSKSAKKLQQRTQANKQELANINNNLMSTLKEYLGSSEQMNSITYNFENINSNVDNGNQSKNISDLSYTDQKEILEKIVSYIVDISLYDIENTALNAAEQLLSDNSVDEKTLKKRAQSLKKLSSIMERYAGGKRNDKKSKNFDTKDIVGYIMHGISTINTEMKNQNENVPEHVQHNAEENVEHDAEENVEHDAEENVEHDAEENVEHDAEENVEHDAEENVEENVEEVEENVEENVEENVEENVEEVEENVEENVEENVEENVEENVEENVEENVEENVEENVEEYDEENVEEVEENVEENVEENVEENVEENVEEVEENVEENVEENVEENVEENVEENVEEYDEENVEEHNEEYDE
What is the function of this protein?
May disrupt the normal intermolecular interactions of the cytoplasmic domain of band 3 and thereby facilitate the invagination of the red cell membrane which is necessary for the formation of the parasitophorous vacuole.
What are the official names of this protein?
Ring-infected erythrocyte surface antigen.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably located on the cytoplasmic face of the membrane where it associates with components of the membrane skeleton.
Protein: BTBD9_DROME
Sequence: MSSQGHHKMSGGGKKGAMEQDYTDVVDLGDRFSADMARLCMNEQYADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETTQRQIPLEVPLEAFKVLLRYIYSGTLLLSTLDEDSTIDVLGMANQYGFQDLEMAISNYLRQYLALDNVCMILDAARLYNLEELTEVCLMFMDRNAGDLLLHNSFNTLSKESLEEVLRRDCFFAPEVQIFLAVWKWSRFNSNVDFKSVVSYVRLPLMNLEHLLQVVRPSGILDPDKILDAIDERSTSKALPYRAALWPEENVAAETFLSRCIQGECRDALLDGDVTTYDMENGYTRHCITDSKDAGIVVELGTFCMINHIRMLLWDRDSRAYSYYVEVSGDQQHWDRVVDYSDYHCRSWQYLYFEARPVRFIRLVGTQNTVNRVFHVVGLEAMHTAKVPRLVNHFVAPKTNVATVEMSAIVTDGVSRTRNALINGDYVRYDWDSGYTCHQLGSGEIVVRLGQPYYLGSMRLLLWDCDDRTYSFYIEISTNRKEWQMVVDRRNDRTRSWQNFHFTPRPVVYIRIVGTRNTANEIFHCVHLECPTQDKNYLKKIADMEKEREKREKEKKTAKTDDDNIASTSGSSLASGHAESPSTSSSSSQSVLRSIHWPPQTREVAVAPLTPPALSPPGTPALPAPLTPATSSPHNNHEQNQPSNISADASHHTSPSSRSNPSPSLSRSRSQSAELEPVPPLVELDTRETL
What is the function of this protein?
Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness.  May function, at least in part, by ensuring dopamine biosynthesis.
What are the official names of this protein?
BTB/POZ domain-containing protein 9.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized to distinct puncta in neuronal cytoplasm.