PharMolix/UniProtQA huggingface dataset:
Protein: CUC2C_HAECO
Sequence: QAGYGNCQACCTGGQAGPPGMPGNPGRPGNPGAPGIPGNPGRPPVQPCDPIPIPPCKPCPQGRPGPPGPIGPPGEPGTPGNPGAPGNDAPPGPPGPKGPPGPPGKAGAPGAAGQPGANAPSEPLVPGPPGPPGPTGPEGPPGPNGAPGHPGAPGAPGEKGPRGQDGHPGAPGNAGHPGQPGQPGPPGERGVCPKYCSMDGGVFFEDGTRR
What is the function of this protein?
Nematode cuticles are composed largely of collagen-like proteins.  The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
What are the official names of this protein?
Cuticle collagen 2C.
What is the protein family that this protein belongs to?
Belongs to the cuticular collagen family.
Protein: MNMG_PROM3
Sequence: MPFSAPPTEHFDVIVVGGGHAGCEAALTAARLGLSTALFTLNLDRIAWQPCNPAVGGPAKSQLVHEVDALGGVIGRLADATALQKRVLNASRGPAVWALRAQTDKRLYSRQMLQLLQQTANLSLREAMVTGLEVKGDPSGGGEHWEPAQGHAAQITGVRTYFGSIYRAQAVVLTTGTFLGGQIWVGNQSMPAGRAGEQAAEGLTEALESLGFQTNRLKTGTPARVDRRSIALDQLEEQPSDAADRFFSFDPTTWVSGEQMSCHITRTTASTHQLIKENLELTPIYGGFLDSKGPRYCPSIEDKIVRFADKDSHQIFLEPEGRDTPEIYVQGFSTGLPERLQLDLLRTLPGLEQCIMLRPAYAVDYDYLPATQLSPSLQTKRVKGLFTAGQLNGTTGYEEAAAQGLVAGLNAARLVHGQEQVHFPREGSYIGTMIDDLVSKDLHEPYRVLTSRSEYRLILRGDNADRRLTPLGYQLGLIDARRWQLFQSKQTALEDEKQRLEKQRIKASDPAAPALEAKTGAKIKGSITLADLLRRPGVHSADLIEHGLVDPELALGVREGAEIDIKYSGYLQRQQQQIDQLKRQSQRRLPANLDYANISTLSKEAREKLTAVGPLNFAQASQIPGVSKADLTALLVWLELQKRRTLAASGHDR
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPMAH_AQUAE
Sequence: MDLLDAWDYFINEVRKFFKEKGYTEVSTPLLLDFPNLDSNVEPVKVEVLERGENKVKWLHTSPEYSMKKLLSRYKRDIFQITKVFRNNEWGRLHRIEFHMLEWYAVGCDYLYLIEELKQLLNKLFGFKEFEVITVEEAFKRHFGEGIPQEESSMKELLERKGIDFSEDEDWETLFYRAFIEVERHLGFNRPTFLINFPERLCALAKVRNGYAERFELFIKGIELANGWTEETNPEEVRKRLEREAKKRNLPLDEDFIKAHEDMPECAGCSLGIDRLFSLFLGKEELVSEFFRA
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase homolog, EF-P--(R)-beta-lysine ligase homolog.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: KTI4_ARATH
Sequence: MTKTTKTMNPKFYLVLALTAVLASNAYGAVVDIDGNAMFHESYYVLPVIRGRGGGLTLAGRGGQPCPYDIVQESSEVDEGIPVKFSNWRLKVAFVPESQNLNIETDVGATICIQSTYWRVGEFDHERKQYFVVAGPKPEGFGQDSLKSFFKIEKSGEDAYKFVFCPRTCDSGNPKCSDVGIFIDELGVRRLALSDKPFLVMFKKANVTEVSSKTM
What is the function of this protein?
Exhibits Kunitz trypsin protease inhibitor activity (PubMed:19825555).  Involved in modulating programmed cell death (PCD) in plant-pathogen interactions (PubMed:19825555).  Can inhibit both serine proteases and cysteine proteases (PubMed:30042779).  May be involved in the modulation of the proteases that participate in the hydrolysis of dietary proteins in the gut of spider mites (PubMed:30042779).
What are the official names of this protein?
Kunitz trypsin inhibitor 4, AtKTI4, Kunitz trypsin inhibitor 1, AtKTI1, Trypsin protease inhibitor.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: NDK_ACIF5
Sequence: MAVERTLSIIKPDAVQKNAIGAILGRFEKAGLRIAAAKMLHLSRDDAGGFYAVHQARPFYGELCDFMSSGPVLVTVLEGEGAIAKNRDLMGATNPKDAAAGTIRADFADSIDANAVHGSDSAETAAWEISYFFGQREIFAH
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_ECOL6
Sequence: MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDRTIESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGSKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisIE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_SHEHH
Sequence: MARYFRRRKFCRFTAEGVTEIDYKDIVTLKNYITESGKIVPSRITGTNAKYQRQLARAIKRARYLSLLPYTDLHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: Y1006_STAA3
Sequence: MTKYTFKPKDFKAFNVEGLDARMEALNEYIRPQLRELGEYFSDFFTSQTGETFYPHVAKHARRSVNPPKDTWVAFATNKRGYKMLPHFQIGMFEDQLFVMFGIMHEAKDKATRAKVFERKFKAIQQLPDDYRVCLDHMKPDKPFIKDLTDDDLIEAIQRAINVKKGEFFIARAITPQDKRLKSDKAFIAFLEETFDQFLPFYSA
What are the official names of this protein?
UPF0637 protein SAUSA300_1006.
What is the protein family that this protein belongs to?
Belongs to the UPF0637 family.
Protein: Y2183_ENT38
Sequence: MSEIDAQKVAQRIDTVLDILVAGDYHSAIRNLEILKSELLDHTNAGNTADSAQPKAPWEV
What are the official names of this protein?
UPF0509 protein Ent638_2183.
What is the protein family that this protein belongs to?
Belongs to the UPF0509 family.
Protein: RNY_MALP2
Sequence: MQQNTVTLILVGVIIFLFISLFFYVIYSFVQKKKNRNFKQIKIQPKKNNKITPTSDQKLKADEFISIINKKREILNHQRADYLKIKETQESYQQLQEVISEYQKKLNLEKIKLIDQMEKEIKDNLNEKAVYYMINAMEQHAEDIISSKFSFTIKLENEGMKGKIIGKDGRNKRHFEQTTKTDLIIEPNMPAITISSPNPIRREKAKRTMEKLLETKNMDIAKISLFYKEVEEGFEQTCYEIGKDALENKLHIFDIDKKMYPIVGQLNFRTSYSQNVLLHCVEAAVLAANIAQKLNIDPIKAKKAAFFHDIGKAVDFEIDNDHVNSGVELAKKFNFEDYIINAIESHHNKVSPKTVYAALVKVVDKLSASRPGARFVSNDEYFKRIEELEKICKSFEGVSDAYVIKSGREIEVIIDPSLVSDDECKILIKDIKFKLEDSDLVNKQPIQITLIRKFTQSITTLGSASRLRT
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL33_NOCSJ
Sequence: MASKTSDVRPKITLACVECKERNYITKKNRRNDPDRMELSKFCPRCRKHTAHRETR
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: FOXO1_XENTR
Sequence: MAEAPLPPPPGVEVDPDFEPFSRPRSCTWPLPRPEFNPSSSANSSPAPSLQPEPAAGNVDFLSNLSLLEESEDFDPAEALGVCGDFPCQDIRQLQPPVPQQHPQQQAGTLCAPSVPSALSPASSPSPLGAQQPRKSSSSRRNAWGNLSYADLISQAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFVRVQNEGTGKSSWWILNPEGGKNGKSPRRRAASMDNNSKFAKSRGRAAKKKATMQSSQDGSSDSPGSQFSKWPGSPSSQSNDDFEAWSTFRPRTSSNASTISGRLSPIMPEQDDLGDADVHNLVYPPSATKLTSTLPSLSEMGNSENMENLLDNLNLLSPNTSTQSSPASMMQQSGYLFTSPNTSLGSPNSEYRKYSYAQTGMNPVSQMPMQTVPENKSGYRAVGQYPVPAGLLKELLTSDSPPHNDILTPVDSAVSQANSRVLAQNSLMAPSSVMPTYGSQPTHNKMSSHPHSHQPPPNHPSVNGRTMTHNSGINRLSTVKTSVQVPMPQPIQMTSMGSYPVNSCNGYGRVGIVSIHQEILPSDLDDMFIESLDCDMESIIRNDLMEDGEADFNFDSILPNQSFPHSVTTTTHSWVSG
What is the function of this protein?
Transcription factor that regulates metabolic homeostasis in response to oxidative stress.  Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'.  Main regulator of redox balance and osteoblast numbers and controls bone mass.  Orchestrates the endocrine function of the skeleton in regulating glucose metabolism.  Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of sox9, which induces chondrogenic commitment and suppresses fatty acid oxidation.  Acts synergistically with atf4 to suppress osteocalcin/bglap activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity.  Also suppresses the transcriptional activity of runx2, an upstream activator of osteocalcin/bglap.
What are the official names of this protein?
Forkhead box protein O1, FoxO1, FoxO1A.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.
Protein: CH60_LIMRJ
Sequence: MAKEIKFSEDARSAMLSGVDKLADTVKTTMGPKGRNVVLEQSYGTPTITNDGVTIAKSIELENQFENMGAKLVAEVASKTNDIAGDGTTTATVLTQAIVNAGMKNVTSGANPVGIRRGIDKATEVAVEALKKMSHDVKTKDDIEQIASISAANPEVGKLIADAMEKVGHDGVITIEDSRGVDTSVDVVEGMSFDRGYMSQYMVTDNDKMEADLDNPYILITDKKISNIQDILPLLQSVVQEGRALLIIADDITGEALPTLVLNKIRGTFNVVSVKAPGFGDRRKAQLQDIAVLTGGTVISDDLGMSLKDATVDQLGQANKVTVTKDTTTIVDGAGSKEAIQERVDQIKQEIAKSTSDFDKEKLQERLAKLSGGVAVVKVGAATETELKEKKYRIEDALNATRAAVQEGFVPGGGTALINVIPALDKIEADGDELTGINIVKAALEAPVRQIAENAGVEGSVIVNELKNEKEGIGYNAADGKFEDMIKAGIVDPTMVTRSALQNAASVSALLLTTEAVVADKPDPNANNQAPAAPQGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRSF1_CHICK
Sequence: MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSEYRVIVSGLPPSGSWQDLKDHMREAGDVCYADVFRDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSVVVAEAVVGATAEAAVIPQEEAEDLHATLPATADPDLVHKRSLALIFL
What is the function of this protein?
May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.
What are the official names of this protein?
Serine/arginine-rich splicing factor 1, Splicing factor, arginine/serine-rich 1.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
Protein: RL14_STRT1
Sequence: MIQQESRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVATVKQATPGGAVKKGDVVKAVIVRTKTGARRSDGSYIKFDDNAAVIIRDDKTPRGTRIFGPVARELREGGYMRIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: DHMA_CAUSK
Sequence: MQVLRTPESRFAGLADWPFAPHYAEITDAGGARLRLHYVDEGPRDGAPVLLMHGEPSWAYLYRKIIPALAARGHRVIAPDLIGFGRSDKPAARGDYTYERHVAWMSAWLEGLDLRGLTLFCQDWGGLIGLRLVAAFPERFAGLVIANTGLPTGAGMTDGFKAWLDFSQNVPEMPIGLIVNMGTGRDLTPAEIAAYDAPFPDETYKEGARQFPMLVPVTPEHASVAENLAAWKVLEHFPGPVVTAFSDGDPVTRGGEAIFQSRMPGALGQPHRTLRGGHFLQEDCPDDIVDIVDAVARPESQS
What is the function of this protein?
Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.
What are the official names of this protein?
Haloalkane dehalogenase.
What is the protein family that this protein belongs to?
Belongs to the haloalkane dehalogenase family. Type 1 subfamily.
Protein: Y212_MYCPN
Sequence: MRKLIKLNVIVFVLLYLGELFASLSFKLISCLKTRNQYSLNGYYALFVFVNIIQKMANSFQKLASSVVLFETEINEFLVLFTDTKNKREESEPVRQVSTTQEYHQVTLDQQHYFNHKLSDYFRLFKDKTFFFEII
What are the official names of this protein?
Uncharacterized protein MG074 homolog.
Protein: UBR11_SCHPO
Sequence: MQLHDPPAPLSQPSASRLQKYLLESAEKHAYDSNEESKTHLLQEVFLSLLNYNEDNWKYFLKEKPGAITSDFRLSRLQHSEPECAQELQDKRSGSKVCGHVFRAGEVIYRCKNCGLDNTCVLCAPCFHATNHEGHETHVSISTSYSGICDCGDPEAWNVDLNCKIHNVPDDEEQKKPEEVIPLELQHSIRTTIHILLDFILDVFSCSPVNLKAQSTVGSILADEEASRLSSAKYGVADRPCNVFRVMLWNDEVHTFDAVVGSVLEALDSSNTAFGLEVAQRVDSIGRFAVATSASVHEAIRIANAISKENLAVNVRTARDFFREDICGILLEWFDDLLESHVCYFADYLQIIVCDEILKNWSPGLEKPAKPEVNFNNLPLEIVNDDDSEDDIYAAEELLDVIANLQDETGVTRIANLGGDEDFEADMTDPTIAGFDHPLDDDNDVNDLLDFETEREDIDDLTDEVMETEENEAAEADYPGVNRNTRQDDVQDISMETESQNETDESQNTENVDYNPQTHTPVPIPTTATQDVVTIRPEFNSQLLNNLRQIINARRRPRPAAVCQVSLREDYWKSPHPIPPSSYSFVESPSSILRLDYFLLFDLKFWKRLRGLLSKLYVVPFNRNLLFKRLMGIRFVIHYRSLATAFLFADREPDHSVMFLSVQFFTTPSLAEAVVKDYDFLTNLNATTLSLLTQSNRPSTLFSSDIEYTPTIQLNRQVLKTRRTYNLFSDLGYLLQHPQVKKLVVDDTRYVHQYIDLLRVFQGVIPQQRAILSHVQWDFPHGKNILFVMQRVAMLSNTVSSCFTQAPYERLFYAIKCIITSITHPKLDIAESLEPLSCIPSSSLTNFTQPLVPFSVSRDPISFYHPLHWMLSNLFSYCRVDASSHWDKDTLLALLDHPLRVCVLLAQIDCNLWIRNGRSILLTDAFYRQLNNIEVSYDKDILAIQTILMFVDPNLVLNAVVQRFEFTDWLYNLTYNEHPNYDTERIPAMLCKMLELLIALITEREQILHVDIQDIIRTRLAQQLCFGPLAYSALLSTISSNLVESLSFDKIREEVTSYKAPDGLHDFGVYSLKDEYYDLVDPYYFHYNKNEREESDTILKKRLAKKNNVSAESIIIEPKIRFLEKDGHDIFFAAVNASTFSLIIFRAIEYALVQAESFGSSDIGNTILGDALQLCLISMKIHEFSKSNDFCSRSCAERYPTDSSIMREFGGSAYCLAELCFAILKSPKYKDVHVKVNAVLAGLQKNDPSAYSNMLEATHFELSTTSSTSDSNEIEKTQEKKRLALEKQKKIMQQFRDQQASFLAQNTDFDIGEDQTEDEVTTEEPEEEVKYHEHIRGNCLLCQEECNDQAPYGVIGIIQGSSLLRKTDVHSEIILDEIYSVPPNLDRESHSRPFGKKYDTVVFNRSKDRLLSAYPPGNNIRGVFVSGCGHLMHLGCFKNYYVARSMYRNDVTAGLSEYYYKYSTAKFFMCPLCRSLSNVLLPMPQIPKMCLNIDTLNFPRSMNGWLEEIGTMSSSSFEYQLVRSSLSDTKDTFRSCFLRPWINSKIISAMLARLKIADGALIDQSNNRDVSDLYDRYCETTKLAMKLVKGSTFTNVSPHDLLNSLAYTVSSLEVSQRCSPKQSGATRSVWFNELGPLTLSFLPTLSDTVLKCVCDQIIKSDQQALLLMESQKLLVCKIFYRHSQLKSMLRNGRMSDHDQIQPFLLSNTFDDFVKISSLMLIFGKQDNILYYVKLFYLSEICKTIISMIKVVADSSVVPDLTINYSQQSKSQFYILCKNVLLWCGSSNNIEILDDESNLLRLMSLVEKYSLPFLRRVALVLYCMFDISLEFNEFSNNEDDSELERLSKLIKVPPLQELYSQMSSDENNQILELIAGWCEHLAQNTWGDSTISLEYPGIYELVKLPHRLENLIDSMQESVCCMCHKTPILPAICMLCGSVICFNARQNTVSSRRLTGECNKHAATCTGSVGIFFITKACGILLLDSISNTGTIMPTPYLDIHGETDLQLRRGCPQFLNQKRYDFVVREQWLRQTVLQKMARHMDMTEMQNWRMA
What is the function of this protein?
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity).  Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).  Targets sde2 for degradation (Probable).
What are the official names of this protein?
E3 ubiquitin-protein ligase ubr11, N-end-recognizing protein 11, N-recognin-11, RING-type E3 ubiquitin transferase ubr11.
What is the protein family that this protein belongs to?
Belongs to the UBR1 family.
Protein: LEU1_SALG2
Sequence: MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: RBL_VISAL
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEQTQFIAYVAYPLDLFEEGSVTNLFTSIVGNVFGLKALRALRLEGLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKAIKFEFAAVDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FLIR_BUCAP
Sequence: MLTFNSFNLAILISNFFWPLVRILAFFSTAPIFNDQNVNKKVKIILSFLIAFLIKPFLPKVNVELFSIIGLFLLFQQILIGIALGLTCQFLFAAFTLSGEIIALQIGLSFANFFNSNRYIGTSLISRWLNILNLLFFLTLNVHLYLVFMLIDSFYKIPVDVNFLSANIFFIFLKFSSNIFLNGVMFALPIMIFFLISTLIMSILNRLSPQISIFSIGFPLNLLIGILILYYLMSMSFPFFKSLVNQLISFIFYTFLKI
What is the function of this protein?
Role in flagellar biosynthesis.
What are the official names of this protein?
Flagellar biosynthetic protein FliR.
What is the protein family that this protein belongs to?
Belongs to the FliR/MopE/SpaR family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: HFQ_SHEHH
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQVESFDQFVILLKNTVSQMVYKHAISTVVPSRPFNVSNHQATNAQAGFNAQHDDGDDK
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: ENVZ_ECOLI
Sequence: MRRLRFSPRSSFARTLLLIVTLLFASLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREIYRELGISLYSNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAGVSHDLRTPLTRIRLATEMMSEQDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNAVLGEVIAAESGYEREIETALYPGSIEVKMHPLSIKRAVANMVVNAARYGNGWIKVSSGTEPNRAWFQVEDDGPGIAPEQRKHLFQPFVRGDSARTISGTGLGLAIVQRIVDNHNGMLELGTSERGGLSIRAWLPVPVTRAQGTTKEG
What is the function of this protein?
Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (PubMed:2997120, PubMed:3536870).  EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (PubMed:2656684, PubMed:2668281, PubMed:2668953, PubMed:2674113, PubMed:2558046, PubMed:2277041, PubMed:1323560).  Also dephosphorylates OmpR in the presence of ATP (PubMed:2668281, PubMed:2558046, PubMed:2277041, PubMed:1323560).  The cytoplasmic dimerization domain (CDD) forms an osmosensitive core; increasing osmolarity stabilizes this segment (possibly by its contraction), enhancing the autophosphorylation rate and consequently, downstream phosphotransfer to OmpR and signaling (PubMed:22543870, PubMed:28256224).  Autophosphorylation is greater when full-length EnvZ is reconstituted in a lipid environment, lipid-mediated allostery impacts the kinase function of EnvZ (PubMed:28256224).  Involved in acid stress response; this requires EnvZ but not OmpR phosphorylation, and suggests that EnvZ senses cytoplasmic acidic pH (PubMed:29138484).
What are the official names of this protein?
Sensor histidine kinase EnvZ, Osmolarity sensor protein EnvZ.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NLP36_CAEEL
Sequence: MSVDLKQQLELADYLGALAVWCIFFGVLFILSVIFNFVCIKKDDDVTALERWGYKKNIDMKLGPHRRSMVARQIPQTVVADH
What are the official names of this protein?
Neuropeptide-like peptide 36.
Protein: TRXH_RICCO
Sequence: MAAEEGQVIGCHTVEAWNEQLQKGNDTKGLIVVDFTASWCGPCRFIAPFLAELAKKLPNVTFLKVDVDELKTVAHEWAVESMPTFMFLKEGKIMDKVVGAKKDELQQTIAKHMATAST
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of the active center dithiol to a disulfide.  The H form is known to activate a number of cytosolic enzymes (By similarity).
What are the official names of this protein?
Thioredoxin H-type, Trx-H.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant H-type subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBP2_GIBZE
Sequence: MSGYDGGYSGGGGRGGGGYGGGGYGRDRGGDRGGDRNGGGFGGRSNGNGYGGGGYGGGGGGYGGGGFGGGAGGDRMGALGSGLKNQEWDINSLPKFEKSFYKEHPDVETRSDADVEAFRRKHQMTIAGSNVPKPVETFDEAGFPRYVMDEVKAQGFPAPTAIQSQGWPMALSGRDVVGIAETGSGKTLTYCLPSIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQEEMKKFGRSSRIRNTCVYGGVPKGPQIRDLSRGVEVCIATPGRLIDMLEAGKTNLRRVTYLVLDEADRMLDMGFEPQIRKIIGQIRPDRQTLMWSATWPKEVRALASDFLQDFIQVNIGSMELAANHRITQIVEVVTEMEKRDRMIKHMEKVMENKENKILIFVGTKRVADEITRFLRQDGWPALSIHGDKQQNERDWVLDQFKTGKSPIMVATDVASRGIDVRNITHVLNYDYPNNSEDYIHRIGRTGRAGAMGTAITLFTTDNQKQARDLVNVLQEAKQQIDPRLVEMTRYGGGGGRGYGGWGRGRGGGRANAHNANNMPIGNRRW
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
ATP-dependent RNA helicase DBP2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Z280D_MOUSE
Sequence: MVTTYIKSDLQLDGRQFFQPKDNLKMAELFMECEEEELEPWQKKVKEVEEDDDDEPIFVAEIASSKPAISNILNRVNPSSHSRGIKNGILNRGFTASFKPTSQRCLNSASNPVAALPVNFHPESRSSDSSVIVQPFSKPGYVTNSPRVLSNNSSELLFDLTQDTGLSHYQGGPTLSIAGLNETSFLSKRPSGSDISSVNPKKPKPSENTSGIDASSVISSEKSPSVISLQVVPSQGANCSSSQSKNGTTFPRACPKCDIHFNLLDPLKNHMTYCCPDMINNFLGLTKADNLNSANEAKTLESEKGKLIMLVNDFYYGKHEGDVLEEQKTHTTFKCFSCLKVLKNNIRFMNHMKHHLELEKQSSESWEKHTTCQHCYRQFPTPFQLQCHIESTHTPHEFSTICKICELSFETEQILLQHMKDNHKPGEMPYICQVCNYRSSLFSEVESHFRTSHENTKNLLCPFCLKVIKIATPYMHHYMKHQKKGIHRCTKCRLQFLTCKEKMDHKTQHHRTFVKPKQLEGLPPGTKVTIRASVGPLQSGSSVTPSISPSTSTLQLSPPEPDNVTAKNHVKLTTSTPNTTISDPSKANETKSNGSKSKNKSKVSNMQKKQSTLSSSNKKSKVNTALRNLRLRRGVHECIECSSEVKDFANHFPTYVHCSFCRYNTSCSKAYVNHMMSFHSNRPSKRYCIFKKHSENLRGISLVCLNCDFLTDVSGLDNMATHLSQHETHSCRVLVEQVSVCIPTSERLSEIKTEAPTKGQEPVSKETARHSRAEGEPGASHSGSKQDKVPSSEEGTGCDASVCEAAAATHCEKDVTVSDTENVSSSKNILSHDPDVGTDTMEKEEKTHHACQEMELKVDQSSESTNPTEAELSSETRQGLQLTSGDVGIDQFLRQGDEPKSVNSDASDPGSVRLEPLTPSEVLEYEATEILHDGDDPSANTSDTVSDQTGGSPGGSNPCRAETAVDLADGEERS
What is the function of this protein?
May function as a transcription factor.
What are the official names of this protein?
Zinc finger protein 280D, Suppressor of hairy wing homolog 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: IHFA_AGRRK
Sequence: MTGKTVTRADLAESVFRKVGLSRTESAELVETVIDEICNAIVRGETVKLSSFATFQVRDKNERIGRNPKTGEEVPISPRRVMTFKASNVLKTRILKAHASRKAKARPANPAS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RL29_VIBC1
Sequence: MKAQDLREKSVEELNAELLNLLREQFNLRMQAATGQLQQTHTLKAVRRDIARVKTVLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.