PharMolix/UniProtQA huggingface dataset:
Protein: SIG1_CRIDS
Sequence: RLCIPYIIPC
What is the function of this protein?
Induces mouse splenocyte proliferation and guinea pig smooth muscle contraction through binding to CCK-BR.
What are the official names of this protein?
Signiferin-1.
What are the subcellular locations of this protein?
Secreted.
Protein: BKDB_MYCTO
Sequence: MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHGRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP
What is the function of this protein?
Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2).
What are the official names of this protein?
3-methyl-2-oxobutanoate dehydrogenase subunit beta, Branched-chain alpha-ketoacid dehydrogenase E1 component subunit beta, BCKADH E1-beta.
Protein: D19L1_HUMAN
Sequence: MEGRPPPEGRPPPRPRTGRAPRGRRRAVFAAVLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIVEAPSFLNGVWMIMNDKLTEYPLVINTLKRFNLYPEVILASWYRIYTKIMDLIGIQTKICWTVTRGEGLSPIESCEGLGDPACFYVAVIFILNGLMMALFFIYGTYLSGSRLGGLVTVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTHILRATKLYRGSLIALCISNVFFMLPWQFAQFVLLTQIASLFAVYVVGYIDICKLRKIIYIHMISLALCFVLMFGNSMLLTSYYASSLVIIWGILAMKPHFLKINVSELSLWVIQGCFWLFGTVILKYLTSKIFGIADDAHIGNLLTSKFFSYKDFDTLLYTCAAEFDFMEKETPLRYTKTLLLPVVLVVFVAIVRKIISDMWGVLAKQQTHVRKHQFDHGELVYHALQLLAYTALGILIMRLKLFLTPHMCVMASLICSRQLFGWLFCKVHPGAIVFAILAAMSIQGSANLQTQWNIVGEFSNLPQEELIEWIKYSTKPDAVFAGAMPTMASVKLSALRPIVNHPHYEDAGLRARTKIVYSMYSRKAAEEVKRELIKLKVNYYILEESWCVRRSKPGCSMPEIWDVEDPANAGKTPLCNLLVKDSKPHFTTVFQNSVYKVLEVVKE
What is the function of this protein?
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
What are the official names of this protein?
Probable C-mannosyltransferase DPY19L1, Dpy-19-like protein 1, Protein dpy-19 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the dpy-19 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NUOD_LEPBL
Sequence: MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHRCFEKLGERYTYNQFLVCTDRMNYVSTPLNNIGWILAVEKMMQVEVPDRVTYVRMIISELSRIMDHIICLGILGVDLGAFSGMLHLFHHRENIYQIIEKLTGARLTTTFCRIGGLERDIYPEFEKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGFSGPNLRAAGVDWDVRKDKPYMLYDKVDFDVPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGAWHADLPHAYLPEKNKVYNNMEELIYHFKIIMHGVKVPPGEHYMATEAANGELGFYIISEGEKSPWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIAGELDC
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: 3HAPM_CUPPJ
Sequence: MAQSVADVMKLVKENDVKFVDFRFTDTKGKEQHVSVPTSHFDDDKFESGHAFDGSSIAGWKGIEASDMLLMPDSNTAFIDPFYEEPTLVLTCDVVEPSDGKGYDRDPRSIAKRAEAYLKSTGLGDTAFFGPEPEFFIFDGVTWNVDMQGCFVKVHSEEAPWSSGKEFEHGNSGHRPGKKGGYFPVAPIDTFQDMRSEMCLILESLGIPVEVHHHEVAGQGQNEIGTRFSTLVQRADWTQLQKYVIQNVAHTYGKTATFMPKPIVGDNGSGMHVHQSVWKDGQNLFAGNGYAGLSEFALYYIGGIIKHARALNAITNPGTNSYKRLVPGFEAPVKLAYSARNRSASIRIPYVANPKGRRIETRFPDPLMNPYLGFSALLMAGLDGVMNKIHPGEAADKNLYDLPPEEDAKIPTVCNSLDQSLEYLDNDREFLTRGGVFSNSMLDAYIELKMEEVTRFRMTTHPVEFEMYYSL
What is the function of this protein?
Catalyzes the isomerization of 3-hydroxylaminophenol (3HAP) to aminohydroquinone, a step in the degradative pathway of 3-nitrophenol.  The enzymatic reaction is regiospecific since it leads to the formation of aminohydroquinone exclusively, without producing the isomeric 4-aminocatechol.  Can also isomerize other hydroxylaminoaromatic compounds, such as hydroxylaminobenzene to a mixture of 2-aminophenol and 4-aminophenol, 4-hydroxylaminotoluene to 6-amino-m-cresol, and 2-chloro-5-hydroxylaminophenol to 2-amino-5-chlorohydroquinone.  Does not act on 4-hydroxylaminobenzoate.
What are the official names of this protein?
3-hydroxylaminophenol mutase, 3HAP mutase, 3-(hydroxyamino)phenol mutase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
Protein: PCKG_ASCSU
Sequence: MRCRSLSHFKDDDFAVVSEVVTHKQNHIPVIKGDFVSLPKHVQRFVAEKAELMKPSAIFICDGSQNEADELIARCVERGVLVPLKAYKNNYLCRTDPRDVARVESKTWMITPEKYDSVCHTPEGVKPMMGQWMSPDEFGKELDDRFPGCMAGRTMYVIPYSMGPVGGPLSKIGIELTDSDYVVLCMRIMTRMGEPVLKALAKNNGEFVRCVHSVGQPKPVATKVINHWPCNPEKTIIAHRPAEREIWSFGSGYGGNSLLGKKCFALRIAMNIGYDEGWMAEHMLIMGVTSPKGEERFVAAAFPSACGKTNLAMLEPTIPGWKVRVIGDDIAWMKFGADGRLYAINPEYGFFGVAPGTSHKTNPMAMASFQENTIFTNVAETADGEYFWEGLEHEVKNPKVDMINWLGEPWHIGDESKAAHPNSRFTAPAGQCPIIHPDWEKPEGVPIDAIIFGGRRPEGVPLVFESRSWVHGIFVGACVKSEATAAAEHTGKQVMHDPMAMRPFMGYNFGRYMRHWMKLGQPPHKVPKIFHVNWFRQSADHKFLWPGYGDNIRVIDWILRRCSGDATIAEETPIGFIPKKGTINLEGLPNVNWDELMSIPKSYWLEDMVETKTFFENQVGSDLPPEIAKELEAQTERIKALKE
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
Protein: RS20_SHEHH
Sequence: MANSKSAKKRALQSEKRRQHNASRSSMLRTYVKKVIAAINAGDHATATAAFAVAQPIVDRMATKGLIHKNKAARYKSRLNAKIKALVA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: SAPN1_PINBN
Sequence: MSPVSVISLPSDLCLPTSFIDRSGRELIPLHITIPNVAMRRQGKLMTRASMSMNLRTAVSDDAVIRRRGDFHSNLWDDDFIQSLSAPYGEPSYRERAERLIGEVKNSFNSMSNEDSESITPLDDLIQRLWMVDSVERLGIDRHFKKEIKSALDHVYSYWSEKGIGCGRESVVTDLNSTALGLRTLRLHGYDVSAEVLNHFKNQSGQFACTLKQTEDQIRTVLNLYRASLIAFPGEKVMDEAETFSAKYLKDALQKVPVSSLSREIGDVLEYGWHTYLPRLEARNYIDVFGQDTGNSQSYMKTEKLLELAKLEFNIFHALQKRELEYLVRWWKGSGSPQMTFCRHRHVEYYTLASCIAFEPQHSGFRLGFAKACHIITVLDDMYDTFGTLDELELFTSAIKRWDPSATECLPEYMKGVYMIVYNTVNEMSQEADKAQGRDTLNYCRQAWEEYIDAYMQEAKWIASGEVPTFEEYYENGKVSSGHRVSALQPILTTDIPFPEHVLKEVDIPSKLNDLASAILRLRGDTRCYQADRARGEEASCISCYMKDNPGTTEEDALNHINAMISDVIKGLNWELLKPNSSVPISAKKHAFDISRAFHYGYKYRDGYSVASIETKSLVKRTVIDPVTL
What is the function of this protein?
Monoterpene synthase (TPS) involved in the biosynthesis of monoterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens (PubMed:23679205).  Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) to (-)-alpha-pinene and, to a lower extent, to (-)-beta-pinene (PubMed:23679205).
What are the official names of this protein?
(-)-alpha pinene synthase 1, chloroplastic, (-)-beta pinene synthase 1, chloroplastic, Terpene synthase (-)alphapin1, PbTPS-(-)alphapin1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSD_ACIC5
Sequence: MVRDGYFYGLALLVVAVIVHLLTGGWSWAVLPLLLAAFFLWFFRDPKRAIPGGEGLVVSPADGKVTEVARIRTPQGELQRISIFLSVFDVHVNRSPVAGTIASVAYQKGLYLNAMDPASAKKNEQNTVVVRADAGYEITFKQIAGLLARRIVFTKRVGDRVERGQRVGLIKFGSRTDILMPPGFEILVRQGQRVSGGSTILARAAEGAGVLAAAPTAPGTLASTERPI
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UBID_HAHCH
Sequence: MQYRDLRDFIRILEQRGELKRITAEVDPHLEMTEICDRTLRREGPALLFENPRGYSIPVLGNLFGTPGRVALGMGAESVESLREIGKLLAFLKEPEPPKGLRDAWSKLPIFKQVMNMGPKEVSSASCQEVIIEGDDVDLYQYPIQTCWPGDAGPLVTWPLVITRGPNKARQNLGIYRQQLIGRNKLIMRWLSHRGGALDYREWREAHPMEPFPVAVALGADPATILGAVTPVPDTLSEYAFAGLLRGNKTEVVRCIGSDLQAPASAEIVLEGVIHPGEMAPEGPFGDHTGYYNEVDRFPVFTVERITQRKKPIYHSTYTGRPPDEPAVLGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRMAVVTMKKQYPGHAKRVMMGVWSFLRQFMYTKFVIVTDDDVNARDWKDVIWAITTRMDPARDTVMVENTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWGRTIQMDADVKARVDDLWSQLGID
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HSLO_CLOBH
Sequence: MKDKLVKAIAKDGQVRIIGAITTELVNEGVRLHNCAPTAAAALGRMLTAGALMGTTLKSEKDTLTLQIHGGGIAKGVVITSYADGHVKGYIGNPTADIEPNSKGKLDVSGIIGKNGNLLVIRDMGLKEPYIGQVPIYTGEIGEDLAYYYTVSEQTPSAVGLGVLVDKDLSIKSAGGFIIQMMPGADEMLADLISYRLEEIPSITEMISKGMTIEEILEYIFEDMDLKILESIVPEYRCDCSREKVERALASIGQKDLKEIYDEGKEEELKCHFCNKAYVFSHDEVGDILENYYSEK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KYNB_GEOTN
Sequence: MMNPWIDISQRLDEHIPVWPGDTPFSYRTRWNKAESGSVNVGQITMSTHTGTHIDAPFHFDNEGKRVIDLDLNIYIGPARVIHLSNPKKIGIDELQTIDLHGVTRLLIYTGAWTNRTTFPETIPYIDPPLAPYLKKYGVRLIGIDLPSVDPLTSKQLPAHHELHRCGIHILEGLVLDHVSPGDYELAALPLPLVNADGSPVRAALRKMG
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: CM3A_CONBU
Sequence: MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDISSEQNSLLEKRVTDRCCKGKRECGRWCRDHSRCCGRR
What is the function of this protein?
Mu-conotoxins block voltage-gated sodium channels (Nav).  This synthetic toxin potently blocks rNav1. 2/SCN2A, and rNav1. 4/SCN4A.  It also moderately blocks rNav1. 1/SCN1A, rNav1. 3/SCN3A, rNav1. 5/SCN5A, and mNav1. 6/SCN8A.  The inhibition is reversible.
What are the official names of this protein?
Mu-conotoxin BuIIIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KBP3_CAEEL
Sequence: MESLNEYMDKIINRLKAVNEKDELVDEGMRKLQKCQEKIMKTRIDAQKHIDERHEQQSFEQQLLNKNMFETEQLEEKLKRLDDENKIGNEREFNKKLEAISAKWTDDVNLLKTTPNEPNDGNRKKLSNLSNILV
What are the official names of this protein?
Kinetochore-binding protein 3.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome. Note=Associated with kinetochores. Localize to kinetochores throughout mitosis. Begin to localize to chromosomes during prophase and persist on chromosomes until the end of mitosis.
Protein: KDPA_ECO81
Sequence: MAAQGFLLIATFLLVLMVLARPLGSGLARLINDIPLPGTAGVERVLFRLPGVSDSEMNWKQYLCAILGLNMLGLAVLFFMLLGQHYLPLNPQQLPGLSWDLALNTAVSFVTNTNWQSYSGETTLSYFSQMAGLTVQNFLSAASGIAVIFALIRAFTRQSMSTLGNAWVDLLRITLWVLAPVALLIALFFIQQGALQNFLPYQAVTTIEGSQQLLPMGPVASQEAIKMLGTNGGGFFNANSSHPFENPTALTNFVQMLAIFLIPTALCFAFGEVAGDRRQGRMLLWAMSVIFVICVGVVMWAEVQGNPHLLALGADSSINMEGKESRFGVLVSSLFAVVTTAASCGAVIAMHDSFTALGGMVPMWLMQIGEVVFGGVGSGLYGMMLFVLLAVFIAGLMIGRTPEYLGKKIDVREMKLTALAILVTPTLVLMGAALAMMTDAERSAMLNPGPHGFSEVLYAVSSAANNNGSAFAGLSANSPFWNCLLALCMFVGRFGVIIPVMAIAGSLVSKKSQPASSGTLPTHGPLFVGLLIGTVLLVGALTFIPALALGPVAEYLS
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILVC_CLOD6
Sequence: MARMYYEKDVDLEVLKNKKVAVLGYGSQGHAHAQNLRDNGVHVMIGLYDGSKSAQKAKEDGFEVKSVAEATKESDLTMMLMPDEKQKKVYEESVKDNLKEGQTLAFAHGFNIHYNQVQPPEFVDVVMVAPKGPGHLVRNVFTKGSGVPALFAVYQDHTKKATETVLAYAKGIGATRAGVLETTFKEETETDLFGEQSVLCGGISELIKLGYKTLVDAGYQKEVAYFECLHEMKLIVDLIYEGGFERMRYSISDTAEYGDYVSGKRVITDAAKQGMQNVLEDIQNGKFAKAWIKENEEGRENFLKTREEEYNTEIAEVGRNLRSMMSFLK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RUVB1_DROPS
Sequence: MKIEEVKSTVRTQRIAAHSHVKGLGLDEAGSALQSAAGLVGQKAAREAAGIVVDLIKSKKMAGRALLLAGPPGTGKTAIALAIAQELGNKVPFCPMVGSEVFSNEIKKTEVLMENFRRSIGLRIRETKEVYEGEVTELTPVETENPMGGYGKTISNVVIGLKTAKGTKQLKLDPSIFDALQKEKVEVGDVIYIEANSGAVKRQGRSDTFATEFDLETEEYVPLPKGDVHKKKEVIQDVTLHDLDVANARPQGGQDVLSMVGQLMKPKKTEITDKLRMEINKVVNKYIDQGIAELVPGVLFIDEIHMLDLETFTYLHKSLESPIAPIVIFATNRGRCVIRGTTDIVSPHGIPLDLLDRLLIIRTLLYSTSDMEQIIKLRAQTEGLQLEDPAFARLSEIGTSSTLRYAVQLLTPAHQMCKVNGRTQITKDDIEDVHSLFLDAKRSSKHLSEKNNKFML
What is the function of this protein?
Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
What are the official names of this protein?
RuvB-like helicase 1, Pontin.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PUR5_HALH5
Sequence: MSDAYKQAGVDIEAGYEAVARMKKHVLRTARPEVIGGLGSFGGMFDLSALNMKEPVLVSGTDGVGTKLMLAFQMNKHDTIGVDAVAMCVNDIVVQGAEPLYFLDYIACGKSEPARIEAIVKGIADGCEQAGCALIGGETAEMPGMYDETEYDVAGFAVGAVEKADLVTGADIESGDLILGLPSSGVHSNGFSLVRKILLHDHGYTLDSEIPALGKKLGEELLTPTKIYVKTVLQTLKTGKVKGLSHITGGGFYENVPRMLPEGLGAEIDYGSWPVPPIFSFIRETGQLSAKDMFSTFNMGIGMAVVVSSDDAPHVIRQIQETGEDAYIIGRVTDTSGVVIGGAFE
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
Protein: RL22_XANOR
Sequence: MTMEAKAILRTARISPQKARLVADQVRGLSAERAVNLLKFSDKKAAHLIKKVVESAIANAENNQGADVDELKVKTIMVDEGPSLKRFMARAKGRGTRILKRTSHITVIVGAAK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: DIM1_CHATD
Sequence: MPKTAKNKRNNAASGPYDKKSKGSGSTNIFKFDKDYGQHILKNPGISDAIVEKAFLKPTDVVVEVGPGTGNITVRALERAKKVIAIELDPRMGAEVTKRVQGTPLAKKLEVILGDVIKLPQIPPCDALISNTPYQISSPLIFKMLSMPQPPRVAVLMFQREFAKRLVAKPGDSLYSRLTVNVNFWATCTHIMKVGKANFKPPPKVESDVVRIEPYLGSARPNIAFEEFDGLLRIAFNRKNKTLRAAFSIKEVLALCEKNYKVYCTLHNIPLDESVLSDPSLTADMDVDMDANSDTDNDNDGDAMEEDDDDMPTFFKEVKEAEAAKEAAKTPSKNPKSKVALIVRAKINKVLTKTGLANKRARQCDQNDFLKLLLAFHEEGIHFS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.
What are the official names of this protein?
Dimethyladenosine transferase, 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase, 18S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: PROT_BACS1
Sequence: MADSDNTPTSRKDFETAIIAKAWKDPEYLRRLRSNPREVLQEELEALHPGAQLPDDLGISIHEEDENHVHLVMPRHPQNVSDQTLTDDDLDQAAGGTGIGVVVAVVAGAVANTGAGVNQVAGGNINVVGNINVNANVSVNMNQTT
What is the function of this protein?
Antimicrobial peptide active against Gram-positive bacteria (MIC=4->125 ug/ml) (PubMed:22983711).  May act by forming transmembrane ion channels, since the peptide rapidly depolarizes the bacterial cytoplasmic membrane, simultaneously decreasing the membrane potential and intracellular potassium contents (PubMed:22983711).
What are the official names of this protein?
Polytheonamide B, Proteusin.
Protein: RL11B_YEAST
Sequence: MSTKAQNPMRDLKIEKLVLNISVGESGDRLTRASKVLEQLSGQTPVQSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRDRNFSATGNFGFGIDEHIDLGIKYDPSIGIFGMDFYVVMNRPGARVTRRKRCKGTVGNSHKTTKEDTVSWFKQKYDADVLDK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L11-B, L16, Large ribosomal subunit protein uL5-B, RP39, YL22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The SYO1-uL5-uL18 complex is transported into the nucleus by KAP104.
Protein: XKDS_BACSU
Sequence: MALTPEVEFEDIEVESEVIETSQTYKIDFENGRITNELITGLEAIRQFVYIALQTERYAYSIYSHNVGNELQDVLTDHETTDAYKKMEIPRLIEEALVYDDRISAVTDFEIEKQGDAFHVSFVVETDEGTLEIEEVIGEDV
What are the official names of this protein?
Phage-like element PBSX protein XkdS.
What is the protein family that this protein belongs to?
To B.subtilis YqbS.
Protein: SRC28_ARATH
Sequence: MARARSRSRSYSPRPRDRSPPRERKGYDDNRLRERPSSRDHESSGPSGLLIRNLPLDARPNDLRDSFERFGPLKDIYLPRNYYTGEPRGFGFVKYRYAEDAAEAMKRMNHKVIGGREIAIVFAEENRKTPQEMRTTNGTSGRHGDYKRTSHRSPRRRYRSHSRSRSPPRRESRHSKVREDDLYSPRRRSRSISRSPLPRNEREYKSRNCRSPREERVLTPIRSRCLSRSRSRSLSR
What is the function of this protein?
Involved in intron recognition and spliceosome assembly (Probable).  Probably active at the 5' splice sites.
What are the official names of this protein?
Serine/arginine-rich SC35-like splicing factor SCL28, At-SCL28, AtSCL28, 28 kDa SC35-like splicing factor, SC35-like splicing factor 28, Serine/arginine-rich splicing factor 28.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family. SCL subfamily.
What are the subcellular locations of this protein?
Nucleus speckle.
Protein: HLDD_PSEA7
Sequence: MSIIVTGAAGFIGSNLLQALNQRGETDIIAVDDLTDGEQFRNLADADIADYLDQNDFIERYARGDFGPVRALFHQGACASTLESNGRYMMENNYRYSCRLLEASLELGVPFLYASSAAVYGAGRTFREARRYERPLNVYGYSKFLFDQRVRRALPQARSQVVGLRYFNVYGPREGHKGRMASVAYHCYQQLRRDGRVVLFGEHDGFPAGGHLRDFVAVEDVARVNLHFLDHPQRSGIFNLGSGRARSFNEVALAVINSVRASADQPPLVLAQALESGLLGYREFPEALRARYQSHTCADLELLREAGYRDDFLSLEEGVGGYCRWLARSA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: PPID_AMAMU
Sequence: MDDRPIVFFDIAIGGQLAGRVAFRLYSDLVPKTAENFRALCTGEKGLGQSGKPLWYKGSAFHRVIKGFMCQGGDFTAGNGTGGESIYGEKFEDEGFPVHHSRPFLLSMANAGPNTNGSQFFITVSATPHLDGKHVVFGEVIKGRSVVRTIENNPATNGDVPKEPVVIADCGQLSSDDPFLAERTSTDGDPYEDYPDDEDQELGNPETVLQIAKTIREVANRLYKQGDISGALQKYSKSIRYLDVHQELPENSPPDLNEQYKSLLAPLLLNSALAAIRIEPHSAANAMNAVANTSRALNRLELSNADKAKAYYRRGLAKTIMRDEVGAEQDLKTANELLPEDGAIAAELAKIIQKKKEQREREKKAYKKMFA
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase D, PPIase D, Rotamase D.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 4OT_BACSU
Sequence: MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIEEMRKDHYAVAGKRLSDME
What is the function of this protein?
Catalyzes both 1,3- and 1,5-keto-enol tautomerization of the diacid 2-hydroxymuconate (2-hydroxy-2,4-hexadienedioate) to produce 2-oxo-4-hexenedioate.  This reaction is highly stereoselective and produces a mixture of stereoisomers, where the (3S)-isomer of 2-oxo-4-hexenedioate predominates.  Also catalyzes the tautomerization of 2-hydroxymuconate to 2-oxo-3-hexenedioate, however this reaction is slower and occurs after the tautomerization of 2-hydroxymuconate to 2-oxo-4-hexenedioate.  Using 2-hydroxy-2,4-pentadienoate, phenylenolpyruvate, (p-hydroxyphenyl)-enolpyruvate and 2-hydroxy-2,4-heptadiene-1,7-dioate, YwhB is a highly efficient 1,3-keto-enol tautomerase, but clearly not a 1,5-keto-enol tautomerase.  Tautomerization of the two monoacids 2-hydroxy-2,4-pentadienoate and phenylenolpyruvate produces a mixture of stereoisomers, where the (3R)-isomers predominate.
What are the official names of this protein?
2-hydroxymuconate tautomerase, (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase, 4-oxalocrotonate tautomerase, 4-OT.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.