PharMolix/UniProtQA huggingface dataset:
Protein: ACCA_METCA
Sequence: MDLKFLDFEQPIAELEAKIEELRHVGFDNEINISEEISKLEEKSRKLTESVFSSLSAWQISQISRHPQRPHSRDYIDLIFQEFHELHGDRAFADDPAIIGGLARLDGAAVLVIGHQKGRDTKEKIHRNFGMPRPEGYRKALRLMRLAERFRLPIVCLIDTPGAYPGINAEERGQSEAIARNLFEMAQLQTPIVCVVIGEGGSGGALAIGVGDRLLMLQYSTYSVISPEGCASILWKSADKAELAAEAMGITSERLMELGLIDSIVPEPLGGAHRDRERMADNLKTELKRNLEELAALPMEELLAMRYERLMGYGVYEEPAT
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_SALHS
Sequence: MEPIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELEAQRPDLITPDSPTQRVGAAPLTAFNQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKSTENVIWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGDNIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGILEGGELPDTHLGRLLQFKAWGLPVSDRVTLCDSPQAVLDFYRNVEKDRPTLGFDIDGVVIKVNSLALQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVQVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEETRPIVFPTHCPVCGSDVERVEGEAVTRCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEREYVHTPADLFRLTAGKLTGLDRMGPKSAQNVVNALEKAKATTFARFLYALGIREVGEATAAGLAAYFGTLEALQTATIDELQKVPDVGIVVATHVFNFFAEESNRDVIGQLLAEGVHWPAPVVINVQEIDSPFAGKTVVLTGSLSQMSRDDAKARLAALGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGITVIDEAEMIRLLGA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: LFTR_SINMW
Sequence: MKETRSKQPDITPDMLLRAYSIGLFPMADSADDPELFWVEPEIRGIIPLDRFHVSRSLAKVIRRRPFDIRFDTAFSEVIEGCAQRAPDRPTTWINDTIRALYAALHKMGHAHSVEAWEGDTLVGGLYGVSLGAAFFGESMFSRRTDASKICLVHLVQRLRSKGFQLLDTQFTTEHLKSFGAVDVPKVEYEVLLAKAIASPNLDF
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GWT1_CRYNH
Sequence: MGDYKSAKEAFVSDNPGASIWSINAVSLVALATYALWIALSPYIRHGLLNNYLICVLPLLFGVTIFSTSPLVFTSFLSIISLAFITKSQKCFKSVSSPEKPKGQWLDESDSDEEPAEPASAAGSAAVSPVKLLPSQVAFASGSLLSPDPTTSPMSPSSSSASGHEDPLGIMGVNRRRSLLEGVSLDVPSHIDSKVRISPVPYLRLKKSRATKAQWVKEKGRLPFLTVYRAHMMLMTVICILAVDFEVFPRWQGKCEDFGTSLMDVGVGSFVFSLGLVSTKSLSPPPPTPTPSSPALNSHIIPLTPSPFTSILISLRKSIPILVLGFIRLIMVKGSDYPEHVTEYGVHWNFFFTLALVPVLAVGIRPLTQWLRWSVLGVIISLLHQLWLTYYLQSIVFSFGRSGIFLANKEGFSSLPGYLSIFLIGLSIGDHVLRLSLPPRRERVVSETNEEHEQSHFERKKLDLIMELIGYSLGWWALLGGWIWAGGEVSRRLANAPYVFWVAAYNTTFLLGYLLLTHIIPSPTSSQTSPSILVPPLLDAMNKNGLAIFLAANLLTGLVNVSMKTMYAPAWLSMGVLMLYTLTISCVGWILKGRRIKI
What is the function of this protein?
Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.
What are the official names of this protein?
GPI-anchored wall transfer protein 1.
What is the protein family that this protein belongs to?
Belongs to the PIGW family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SLT11_YEAST
Sequence: MNDEINEPPPNICEQCLGDEANIRMTKIPQGSECKICTLPFTLYHFKTSKRSNNIIKTLICVRCATQRNICQCCMLDSRWHIPIQLRDHLISLVNEENVMTEEAKNDMMKRFLSLKNVKLGGAQITSDPSEADNIVDKLKNILLRATSDGPSTPLIKNTTALYKNEKGANEVKNLEKYASVDISHILKKLPLNESFLKNPSTKSFFLYNIDASIPEWKITDTVSQLLGIKKWKDGNSLSLIVNHKAKCGGLRFQSSELGERFVSKISETLVTPKGLKRGVLLIDRFRIFIIPWSSGFSAASFGTNTAENIKLSLSLNKLIQLELGLSFPTKSTDNAKNDKKKTSKKVHKDRSKKSKPRANKLTI
What is the function of this protein?
Involved in pre-mRNA splicing.  Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome.  Binds to RNA.
What are the official names of this protein?
Pre-mRNA-splicing factor SLT11, Extracellular mutant protein 2, Synthetic lethality with U2 protein 11.
What is the protein family that this protein belongs to?
Belongs to the SLT11 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SERB_IDILO
Sequence: MKHSSGLIVFDMDSTLIHIECIDEIARLNNRYTKVSAITEAAMRGEIDFAESLTQRVACLEGIKESDLESLFSPIPFNPGAKELIQALQAAGWKTALVSGGFTWFANRVQAALNLDAVVANQLEVADGCLTGKVLGDIVDAQVKAEQLQQLAGHWNIPPDRTVAVGDGANDGLMLKAAAVGIAFNAKPALQAIADYSVNSNNLLEILGCLKQSELIEPVI
What are the official names of this protein?
Phosphoserine phosphatase, PSP, PSPase, O-phosphoserine phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. SerB family.
Protein: THIE_NITEC
Sequence: MIDPPMDRIKVSGLYAITPDIENIDRLCEMAYHVLAGGVSWLQYRNKKANSRLRLMQALEIHLLCKQFQVPLIINDHMDLVMEIDAEGLHVGGEDTSVAAARHYLGRNKIIGVSCYNQLSHAIEAEKAGADYVAFGAFYPSMTKVDAYQAPIHLLDAAKKTLNIPIVAIGGINLDNAEALIARGCDAVAVSQALFSAQDIQSAARHFSKLFC
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: EPD1_ONCMY
Sequence: MQAFAVAALSIWLCLGATTLAESHGPQHCTSPNMTGVLTVLALTGGEIKATGHYSYDSTDKKIRFTESEMHLNKTEHLEDYLMLFEEGVFYDIDMKNQSCKKMSLHSHAHALELPAGAAHQVELFLGSDTVQEEDIKVNIWTGSVPETKGQYFLSTTVGECLPLSTFYSTDSITLLFSNSEVVTEVKAPEVFNLPSFCEGVELEEAPEGQKNDFFSLFNSV
What is the function of this protein?
May play a role in neural plasticity.  May be involved during axon regeneration.
What are the official names of this protein?
Ependymin-1, Ependymin I, EPD-I.
What is the protein family that this protein belongs to?
Belongs to the ependymin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGC_SYNE7
Sequence: MHESSRLPVGIIGASGYGGVQLVRLLQDHPQLEVAYLGGDRSAGKEFAELYPHLGPHLNLTIEAIDVDRIAERCAAVFLSLPNGLAYDLAPALLERGCKVLDLSADYRFHDLKTYALWYGGDRQDAAVAHTAIYGLPELYRNRIANAQLIGCPGCYPTASLLALAPALKQGLIDPDTIVIDAKSGTSGAGRQAKTNALLAEAGNSVGAYGVARHRHTPEIEQICSDLSGHEVLLQFTPHLMPMVRGIHATIYAKLRDPNLTTEDCLTVYQAFYRNAPMVKVLTHGTYPQTKWAAGTNLCYLGLEVDARTGRIVLLSAIDNLIKGQAGQAIQCLNLMQGWEEGLGLPTLCYYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDHB_DICDI
Sequence: MNKILTRSFSTGANFFASGKGKAPVRVAITGASGQIGYQLLFRIASGDMLGKDQPIILQCLELPGAMNSLKGVSMELDDCAFPLLKGIVQSDKPEEAFAGADYALLVGARPRSKGMERGDLLKANAEIFSVQGKALDKSANRDTLRVLVVGNPANTNALIAARNAPNIDPKRFSAMTRLDHNRGLAQLADKTGSAVTDIEKFCIWGNHSATQYPDINFGTVKGKSLVDTINDQKWVKDNFIPTVQQRGAAIIAARGLSSAASAASAAIDHMRDWTYGTNGQWTSMAIYSEGEYGADKGLYFSFPVIVDNKGKYEIVKGLKLDQFSQERFDATRKELLSEMDGVKELLP
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Probable malate dehydrogenase 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RR14_SACHY
Sequence: MAKKSLIQREKKRHKLEQKYHLIRRSLKKKIRSKVSPLSLSEKTKMQEKLQSLPRNSAPTRLHRRCFLTGRPRANYRDFGLSGHILREMVYACLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y4OC_SINFN
Sequence: MDEVAIKDEFYRLIPSRFPPVAVYEGLVSEDKIEALVEIENKTNPRLQSEGRLLSAHTDPRAPRLQNWNLAPFKYLNPEGIRFFDGSRPALELADDRQTALAMSVERRQAFLSRTKEAPIGLDMRLLKTPVSGRFIDFRKYPIDLSCEERWRLGGSVPEGADGVIYHPPERPSAICIAVLRGDVLGRTIQTVHYRYVWNGTRISLLYAFDDAGNEIRPEVLGGADDAFAV
What are the official names of this protein?
Uncharacterized protein y4oC.
Protein: CDPK6_PLABA
Sequence: MVLELLKNNYERNDEHYYNEKVENNTSKHKKKKKKKKKHILVEESEKYDRNIDSENNEEAYNAYELIKTKPNNIYEEKYDFSFQNLDKKCLREKNNMRESYRNSKDIIQYGTNENDIFTEDMLENDNFDDDSFVEDDTMDYKTYNSYTKPEFNLFSKYSTESKKKNIMNNKKHSKIEDFYKKYKNNSEYSKQANEHDASIIQFLNNNKKSVDCGKMKDINFKKNDSQNYSESNKYKNEFFKNYNYDNKYTNNYAHDNNQDSNSYYYADENEPKDNHEEDNDTGDTYADNEEDEDNRDDNDDYSQYNQCEVESDTNQIRPNEKRYNESIKHINDSNLKINKELLLKRETYTKRDNIFYIKKDIIPYKKEHNNNRFSLYDSSKNNNEHNNNYEIKFMNYKKDSEKEGEQWLKNIKKEKDEEFLKKYMYENALKKTHSSKDLQFNRLDDEKNILHHDINVDNKMVRLDKYERSNIRDMRNKTNKCNMLRHDTAEFNKIRRKDEINNYSEYANKCLAGNIYEEDDSYILKRNELGHKELKVIDNPILNINPDDKKKPNIKSFLDKIKYRKNNELFLKNEHEKYVGIQETNKKDKIKMKFADILHTKNFSNFFHRGKNSIAKSLSPNNDKKNTSFNNEVFNLNILGKNDKNSDYKQYNINCSPYDHENTSFHPSVREETKYYENKESRKRLDYNCDEDNYIENSIQRYHENNIDYNSINIERTINLREDIKYNEFLNKPDKINSENFSNNFNDNKQKSLKNDDSNKIRDTNKLYYHDHLENTMRSNYIQKEYTEKISDILESNSNNMRKFINKMDYYTKKYEQNLYKNDEDIYTKENKFPDSRKEFYNKSDSPMKVTDGIKDSQYENYNRIKYKLKMKQEKQDKEDETDINIDKKLSRKMIENNKLKEENESNDELIVTPFYIKSKIDKVLKNSEIFERSARATFKQFDVKNKNFLHFSEIESLIQKLCYNLELPPVDKKILSIVYKDYDSSKNNCMNYMDFRQMYWDLLKQIKKKYYPTKNFKIKRNCIISRKKLQGYDYSSIYNYLSFKKILGCGAFGEVHLVEDNICKLYKVVKILKKKKMKNIKVNEEINVLIYLDHPNIIKIFDVYESVNCTYIVMELCEGGELMNKIKKPQIFSETYIKNIMFQILCAIAYMHSNNIAHKDLKPENILFKTDGYDTLKIIDFGLAELINKSEGISKTAAGTVLYMAPEVFKKKFTIKCDIWSAGVIMYFLFTKSLPFTGNTYEEVKQNIFNSEPDYQFLKLKMSKPALHLLKLMLEKDYSRRPMAAVLLHHPWFQGYFDPIDILPSTLNNIKSYMKHSNIRNVIVNIMAHELCVINNHVKYINDIFLKIDSNHNGSLSHREIYNVLSNAGVKKWDINRIIQALDVNDKGCITYTEFIAGCYRWKNIDSTFLKAAFNKIDKDEDGYISKSDLATLVHDNGVNNKDIENFFISVHSIKKNITKDKKINKISFEDFKDYMLSTF
What is the function of this protein?
Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels (By similarity).  In sporozoites, probably involved in the secretion of the cysteine protease that cleaves circumsporozoite protein CSP, thereby exposing CSP TSR domain, which binds with high affinity to highly sulfated heparan sulfate proteoglycans (HSPGs), resulting in productive invasion of the host hepatocytes (PubMed:18005753).
What are the official names of this protein?
Calcium-dependent protein kinase 6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.
Protein: PACC_ASPFU
Sequence: MSEHQDTATNNNTTASPSATAAPMPAPISQEQPSSQPAATTPAPVSTSTPPASVTATAAAATAAVSAPQANGTPPSDEQLSCLWQGCSEKCPSAEALYDHICERHVGRKSTNNLNLTCQWGSCRTTTVKRDHITSHIRVHVPLKPHKCEFCGKAFKRPQDLKKHVKTHADDSVLVRSPEPGARNPDMMFHGAGKGYAAAAHYFEPSLNAVPSQGYAHGAPQYYSSHPPHQPSNPSYGNVYYALNHGHDGHASYESKKRGYDALNEFFGDLKRRQFDLHSYAAVGQRLLGLQNLSLPILTGGPLPEYQPMPAPVAVGGGYGPGGHGAPVYHLPPMSNIRTKNDLINIDQFLQQMQDTIYENDDHVAAAGVAQPGAHYVHGGMSYRTTHSPPTQLPPSHAVATTSASTSMSNPATHSPPTGTPALTPPSSAQSYTSARSPISISSAHRVSPPHHDGGSGMYPRLPSTTMADSLAGGYPTASSAAPPSTLSGIFDDDRRRYTGGTLQRARPEERRPSIQMDTSHDGKEDGERTPTGKARSSGSDSPVRISANLIDPALHSSSPSDAEAALRTAQAATEVADRADSQWVEKVRLLEYLRSYIASRLERGEYDSDSDDHASAAASPVIKHDGHMDGVESSHKPITAEETSAPPAAKAESNHGVMYPTLHGLDGDEDTKMHH
What is the function of this protein?
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH.  At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes (By similarity).
What are the official names of this protein?
pH-response transcription factor pacC/RIM101.
What is the protein family that this protein belongs to?
Belongs to the pacC/RIM101 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL37_LEIIN
Sequence: MTKGTTSMGQRHGRTHILCRRCGRNSYHVQWERCAACAYPRASRRRYNWSVKAIKRRRTGTGRCRYLKVVNRRIANHFKTPKA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
60S ribosomal protein L37.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL37 family.
Protein: RPTOR_MOUSE
Sequence: MESEMLQSPLMGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEAHELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRSPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYTTGQEACLQGNLIAICLEQLSDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAERTDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESNFCTVALQFMEEEKNYPLPSPAATEGGSLTPVRDSPCTPRLRSVSSYGNIRAVTTARNLNKSLQNLSLTEESGSSVAFSPGNLSTSSSASSTLGSPENEEYILSFETIDKMRRVSSYSALNSLIGVSFNSVYTQIWRVLLHLAADPYPDVSDLAMKVLNSIAYKATVNARPQRILDTSSLTQSAPASPTNKGMHMHQVGGSPPASSTSSCSLTNDVAKQTVSRDLPSSRPGTAGPTGAQYTPHSHQFPRTRKMFDKGPDQTTDDADDAAGHKSFICASMQTGFCDWSARYFAQAVMKIPEEHDLESQIRKEREWRFLRNTRVRKQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKAYLQKHPEGHIVSVSVNGDVRFFDPRMPESVNVMQIVKGLTALDIHPQANLIACGSMNQFTAIYNGNGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR
What is the function of this protein?
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates.  mTORC1 is activated in response to growth factors or amino acids.  Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1.  Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases.  Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis.  mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).  mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.  Involved in ciliogenesis.  mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (PubMed:33495318).
What are the official names of this protein?
Regulatory-associated protein of mTOR, Raptor, p150 target of rapamycin (TOR)-scaffold protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RAPTOR family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome. Cytoplasmic granule. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.
Protein: UBIA_SALDC
Sequence: MEWSLTQSKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGMPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTVNRPLPSGAVTEKEARNLFVVLVLLAFLLVLTLNAMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESLPLSCWLMFLANILWAVAYDTQYAMVDRDDDIKIGIKSTAILFGRYDTLIIGILQLGVMALMALIGWLNGLGWGYYWAVLVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MRD1_USTMA
Sequence: MSRLIVRGLPSYLTDARLREHFSQKGAVTDVKLMRRPDGTSRKFGFVGYRSEQEAQQALDYFNRTFIDTSRISIELAKKIGDEELVHQREERRNRRNAGAGPEGSASTSDARKRKADKSDTQQEEGSGKKKPKKGGAISFEEFMSVMQPKAKRKAWQNEDALPEQTMQDIVAPEEAIQKKAARKALKKADAAAAATATAESTAAQPDSGREETPEPDAAANDVGLTDEEYMRLRMKHRVGTDLDTLEQSSSGPEFEQSDNEKDDDDAAADSDPESEDEPIHDQGFECKQAEMQRKAQQAAEKDQKLVDQIMESGRLFIRNLPFAASGDEILAFFESFGTVKQVHIPLDKQTKASKGLAFVSFSDPAHALAAYRAKDGSTFQGRLLHLLPAVNKDALAETGSKKTATLKQARAEQKKQDATKDFNWSMLYMSSDAVASSIADRLGVNKSDILNPGANGGADNAAVRLALAETRIIQETKEFLAQQGINVDAFQGAKGPRSDTTILVKNIPYGTSAEEVEKLFGEHGEVDKVLIPPSGTIAVVEMPVVNEARLAFRAIAYKRFKGGILYLEKAPVGLLTQHKVGEKVVKQAPIVGKSIDSSNPSVDLDGPAGAGAGDEAVDGATLYVKNLSFSTTDERLTAFFHGLSDFAFARIQTKPDPRRPGARLSMGYGFVGFKSIDAARTAQKAMDGKVLDAHTLVVTFARRNAEASTTSISSGGSTKILIKNLPFEATKRDIRDLFSSQGQLKSVRLPKKFDNTTRGFGFVEYSTVREAQSAMEALKHTHLLGRHLVLQWSHLASSTQQQVDMQRSKTKQHFVNTHDNAARADPSKRAKIKLNSAQISEAIKQAKRQRDDVDDDE
What is the function of this protein?
Involved in pre-rRNA processing.
What are the official names of this protein?
Multiple RNA-binding domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the RRM MRD1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ODP2_STAAW
Sequence: MAFEFRLPDIGEGIHEGEIVKWFVKAGDTIEEDDVLAEVQNDKSVVEIPSPVSGTVEEVMVEEGTVAVVGDVIVKIDAPDAEDMQFKGHDDDSSSKEEPAKEEAPAEQAPVATQTEEVDENRTVKAMPSVRKYAREKGVNIKAVSGSGKNGRITKEDVDAYLNGGAPTASNESAASATSEEVAETPAAPAAVTLEGDFPETTEKIPAMRRAIAKAMVNSKHTAPHVTLMDEIDVQALWDHRKKFKEIAAEQGTKLTFLPYVVKALVSALKKYPALNTSFNEEAGEIVHKHYWNIGIAADTDRGLLVPVVKHADRKSIFQISDEINELAVKARDGKLTADEMKGATCTISNIGSAGGQWFTPVINHPEVAILGIGRIAQKPIVKDGEIVAAPVLALSLSFDHRQIDGATGQNAMNHIKRLLNNPELLLMEG
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: CAS_ORYSJ
Sequence: MWRLRVAEGGGDPWLRTKNGHVGRQVWEFDPAAGDPDELAAVEAARRGFAARRHELKHSSDLLMRMQFAKANPLKLDIPAIKLEEHEAVTGEAVLSSLKRAIARYSTFQAHDGHWPGDYGGPMFLMPGLIITLYVSGALNTALSSEHQKEIRRYLYNHQNEDGGWGLHIEGHSTMFGSALTYVSLRLLGEGPDSGDGAMEKGRKWILDHGGATYITSWGKFWLSVLGVFDWSGNNPVPPEIWLLPYFLPIHPGRMWCHCRMVYLPMCYIYGKRFVGPVTPIILELRKELYEVPYNEVDWDKARNLCAKEDLYYPHPFVQDVLWATLHKFVEPAMLRWPGNKLREKALDTVMQHIHYEDENTRYICIGPVNKVLNMLACWIEDPNSEAFKLHIPRVHDYLWIAEDGMKMQGYNGSQLWDTAFTVQAIVATGLIEEFGPTLKLAHGYIKKTQVIDDCPGDLSQWYRHISKGAWPFSTADHGWPISDCTAEGLKAALLLSKISPDIVGEAVEVNRLYDSVNCLMSYMNDNGGFATYELTRSYAWLELINPAETFGDIVIDYPYVECTSAAIQALTAFKKLYPGHRKSEIDNCISKAASFIEGIQKSDGSWYGSWAVCFTYGTWFGVKGLVAAGRTFKNSPAIRKACDFLLSKELPSGGWGESYLSSQDQVYTNLEGKRPHAVNTGWAMLALIDAGQAERDPIPLHRAAKVLINLQSEDGEFPQQEIIGVFNKNCMISYSEYRNIFPIWALGEYRRRVLAADK
What is the function of this protein?
Converts oxidosqualene ((3S)-2,3-epoxy-2,3-dihydrosqualene) to cycloartenol.
What are the official names of this protein?
Cycloartenol synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: PYRG_BACAC
Sequence: MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITNEIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQIKSDIGRDNVMYIHCTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEARDADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYVELQDAYISVVEALRHAGYSFDTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGVEGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEGANSSEINPDTPYAIIDLLPEQKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVFSGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVKASLTNKESK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: SCDA_STAAE
Sequence: MINKNDIVADVVTDYPKAADIFRSVGIDFCCGGQVSIEAAALEKKNVDLNELLQRLNDVEQTNTPGSLNPKFLNVSSLIQYIQSAYHEPLREEFKNLTPYVTKLSKVHGPNHPYLVELKETYDTFKNGMLEHMQKEDDVDFPKLIKYEQGEVVDDINTVIDDLVSDHIATGELLVKMSELTSSYEPPIEACGTWRLVYQRLKALEVLTHEHVHLENHVLFKKVS
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein ScdA.
What is the protein family that this protein belongs to?
Belongs to the RIC family. ScdA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_LEGPL
Sequence: MAKELTLSIIKPDAVAKSVIGEIYTRFEKAGLDIVAAKMTQLSREQAESFYDIHRARPFFKDLVDFMISGPVMIQVLKGENAVAKNREIMGATNPKEAAPGTIRADFADSIDANAVHGSDSLENAAREIAFFFEPHELCNR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABA_AZOVD
Sequence: MTKQHAYTREDLLRCARGELFGPGNAQLPAPNMLMVDRITHISDVGGKYGKGEMVAELDINPDLWFFACHFEGDPVMPGCLGLDAMWQLVGFYLGWQGNPGRGRALGSGEVKFFGQVLPTAKKLTYNIHIKRTISRSLILGIADGTVSVDGREIYSAEGLRVGLFTSTDSF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.