PharMolix/UniProtQA huggingface dataset:
Protein: FLIN_AQUAE
Sequence: MEEQTKEIQEEKKETPQEEVREEKKEEKKVSVIELIQHFSDIPVEVEVVVGRANKTLGELLAMGIGSVIEIDREPKDLVDIKVNGKLIAKGELVIIDGKIGVKIKEVVKEQR
What is the function of this protein?
FliM is one of 2 proteins (FliG, FliN) that might form a switch complex that is proposed to be located at the base of the basal body.  This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (Potential).
What are the official names of this protein?
Flagellar motor switch protein FliN.
What is the protein family that this protein belongs to?
Belongs to the FliN/MopA/SpaO family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Protein: END3_PICGU
Sequence: MPQLEEWEIKKYWEIFQGLKPQDNKLSGSKVSPVLKNSQLPQDKLSKIWELSDIDSDGNLDFEEFCIAMRLIFDIVNGSQSDVPAELPGWLIPASKAYLIQANRAVATGNNQYDGGRSSNDDEEDEELLSDDFDWYISPTDKATYESIYNSNSDSYGRVRFQSLEGLYQTLTKVPKESISSAWNLVNPKSFETIDKDQTLVFLHILNQRENGKRVPHGVPASLRATFSKETPSYDLSESVPQVSSPTSANNKKAFGESYLQKVGRSTTNERGTDFSATEGTDWEEVRLRRELANLEDLLNKTSKESSTTQTNELGVTKHEYEQLLKYKEEQLKVKPDKNLTDVKNDIELIEGQVRELEQYYARKQAELQQLDQEIAQLS
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein END3, Endocytosis protein 3.
What is the protein family that this protein belongs to?
Belongs to the END3 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: IF1_ROSCS
Sequence: MSKKKDVIEMEGTITEPLPNAMFRVKLENGHEVLAHISGRMRMNYIRILKGDRVLVELSPYDLTRGRITYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_ECOSE
Sequence: MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: METI_VIBCH
Sequence: MSFNTIAQWFALNSDLLLTATWQTLYMVAIAGAVGFALGIPLGVILHTTKKEGLLENLPLNRALGAVVNIGRSVPFLVLMVAIIPVTKLIVGTFIGTTAAIVPLTIGAIPFVARLIESALLEVPTGLVEAAQSMGATPLQIIRKVLLPEALPTILNSVTITLVTLVSYSAMAGTVGGGGLGDVAIRYGFHRYDITIMAVTVVMLIVLVQIIQSIGDALVRRVDHR
What is the function of this protein?
Part of the binding-protein-dependent transport system for D-methionine.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Probable D-methionine transport system permease protein MetI.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PFKA_SPITD
Sequence: MKRPATRTFGILTSGGDCPGLNAAIRGVTKAAYWRYGMSIIGISHGYRGLIEGDARLLHPRDFDGILTRGGTILGTSREKPFKPDPGEKDSEAGSRKVEAIIENYHKLHLDCLVVLGGNGTHKTAYLLQQAGLNVIGLPKTIDNDIWGTDVTFGFHSAVDIATEAIDRLHSTAHAHNRVMVIEVMGHKAGWLALYAGIAGGGDIILIPEIPYDLAHIVHHLQTRQQRGKEFSIVVVAEGALSREESLMSKEERKKRRKKNRFPTKGYEVAHLIQEATGMETRVTVLGYLQRGGTPSPYDRLLATRFGTAAAELLYRGDYGKMVALRDGEVVAIPLGEVAEKLKTVPPDHPLIDTARAVGTCFGDGV
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CU16_MANSE
Sequence: MKLIILVALTLAAVVANEPEPPKILRSEYDQKPEGSYVFGFETEDGISRDETGEVKEALDEDNKPHSVVVVRGQYSYVDPDGNPQVIKYYADETGYHAEGDSIPKVPSRR
What is the function of this protein?
Component of the cuticle of the larva of tobacco hornworm.  Seems to participate in the formation of 5- to 10-fold thinner lamellae in the endocuticle.
What are the official names of this protein?
Larval cuticle protein 16/17.
Protein: PYRE_BACC4
Sequence: MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATAGIAHAAWVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEKLEAANVVSYSLSDYSALTEVAAEKGMIGQAEMKKLQEWRKNPANEAWITA
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: GLMU_BUCAP
Sequence: MLKKEINVVILAAGKGTRMQSSYPKVLHKLGGKTILEHVINIAKSVKPKKIILVYNNKEKEIKSKISDTSIDWVIQKEQKGTGDAILKASKKFSDKDDIVVLYGDMPYISIESIKKLFTSKKQSDISLLTAYVKNPDGYGRVFKKNGKVIKIIEEQDANFHEKKIKEVYSGTFIANGKDLKRWLNQINNKNIKKEFYATDIVHFANLENSTIKTVQVLNCKEILGVNNKLQLSILEKIFRKKQVNDLLLSGVTLKDPNHFILRGILKHGKNIEIDTGVILEGNIILGNNIKIGVGSVIKNSFIDDQTEIKEYTIIENVKIGKKCIIGPFAHLRPKTVLDDQIHVGNFVEIKDSIIKKESKIKHLSYFGNSEIGSQVNIGAGSITCNYDGVNKFKTIIGDNVLIGANTKLIAPIKITKNATIAAGTTLTQDVNTPCLIYNNKEQKQKKNWKRPQKIIKKTDQ
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR4_SODGM
Sequence: MEILRGSPALSAFRINKLLVRCRDARLAVDDIYAEYIHFADVSAALDEDALSRLQRLLKYGPSLAEHQPQGRLLLVTPRPGTRSPWSSKATDIAHNCGLPQIKRLERGLAYYIQAPQLSEPQWGYLAALLHDRMMETVFTRLEEAAALFAQHAPAPVTLVDVLGEGRGALEAANLALGLALAQDEIDYLFAAFTRLGRNPSDVELYMFAQANSEHCRHKIFNADWVIDGQPQAKSLFKMIKNTFEQTPEYVLSAYKDNASVMEGSAVGRFFPDAQAGRYDYHQEATHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEEDFGRPERIVSALDIMTDGPLGGAAFNNEFGRPALTGYFRTYEERVDSHNGVELRGYHKPVMLAGGIGNIRASHVQKGEISVGAKLIVLGGPAMNIGLGGGAASSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQRGEENPILFIHDVGAGGLSNAMPELVSDGGRGGRFQLREIPNDEPGMSPLEVWCNESQERYVMAVAPERLAEFDAICRRECAPYAVIGEATDALHLSLDDAHYDNRPIDLPLDVLLGKTPKMQREAVSLQAAGFPLNRDGIKLAEAINRVLHLPAVAEKTFLITIGDRSVTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSLGERAPVALLNFAASARLAVGEALTNLAATHIGDIKRVKLSANWMAAAGHPGEDAGLYQAVKAVGEELCPALGLTIPVGKDSMSMKTRWQHGAESREMTAPLSLVITAFARVEDVRATVTPQLQPARDNVLLLIDLGAGHHALGATALAQVYRQLGDETSDVRDAGQLAAFFRVMQQLVAQGWLLAYHDRADGGLLVTLAEMAFAGHCGIDADIGPLGDDALAALFNEELGAVIQIDEADRDAITALFHQEGLADCLHYLGTAQPGDRFILRAGERSLYSESRTTLRTWWAETSWQMQRLRDNPESADQEHASRQDDNDPGLTVALSFDPKDDIAAPFIAKGARPKVAVLREQGVNSHVEMAAAFHRAGFEAIDVHMSDLFTGVQTLEGFHTLVACGGFSYGDVLGAGEGWAKSVLFNLRVRDEFEAFFHRPQTLALGVCNGCQMMSNLRELIPGAELWPRFVRNKSERFEARFSLVEVTQSQSLLLQGMVGSRLPIAVSHGEGRVEVRDAAHLAAIEHAGLVALRYVDNYGKVTENYPANPNGSPNGITAVTNASGRVTLTMPHPERVFRTVSHSWHPAEWGEDGPWMRLFRNARKQLG
What is the function of this protein?
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CACB1_RABIT
Sequence: MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVEGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQSRLSSSKSGDNSSSSLGDVVTGTRRPTPPASGNEMTNLAFELEPLDLEEDEAELGEQSGSAKTSVSSVTTPPPHGTRIPFFKKTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHLFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQVQVLTSLRRNLSFWGGLETSQRGGGAVPQQQEHAM
What is the function of this protein?
Regulatory subunit of L-type calcium channels (PubMed:7509046).  Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (PubMed:7509046).  Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane.  Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit.  Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity).
What are the official names of this protein?
Voltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the calcium channel beta subunit family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein.
Protein: YDHC_ECOLI
Sequence: MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFAAIMPLVGLSPALAPLLGSWLLVHFSWQAIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLRSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVIGLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHSESH
What are the official names of this protein?
Inner membrane transport protein YdhC.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Bcr/CmlA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROB_BRASB
Sequence: MTAPLKTFDPIIVDVALGERAYDIVIGRGVLASLGQRIAALRPGVRTAIVTDRTVAAHWLKPTEAILAEAGIPSSTIVVEEGEGSKTYAGLEKVSEALIAAKIERNDLVIALGGGVVGDLAGFAAAILRRGVNFVQVPTSLLAQVDSSVGGKTGINSPQGKNLLGAFHQPVLVIADTAVLDTLSPRQFRAGYAEVAKYGLLGDAGFFTWLEANHADIVTGGAAREHAVATSCRAKAAIVARDERETGDRALLNLGHTFGHALEAITGFSDRLFHGEGVAVGMVLAAQFSAELGMLPPDDVTRIERHLAAVGLPTHLQDIAGFAQEGIGDADRLLALMAQDKKVKRGKLTFILMEAIGRAVIAKDVDPARVRDFLQAKLHRRG
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_SYNC1
Sequence: MKGKRSEAITQGFERAPHRALLMGTGIPRKELGKPLIGIATSFTDLIPGHIGMRDLERFIEKGVHTGGGYSFLFGIPGVCDGIAMGHKGMHYSLSTRELIADMVESIAEAHRLDGLVLLTNCDKITPGMLMAAARLDIPCIVVTAGPMLTGTGRGGRRYSFVTDTFEAMARYKAGEINAAELQQCEDRACPGAGSCQGLFTANTMAILTETLGMSLVGCGTALAVSSLKRQIAFASGERIVSLVREGITPRQILTREAFENAIRVDLALGGSSNTVLHLLSIAHEAEVDLPLDLFDKLSRETPQLASMNPGGKHFMEDLDAAGGVPGVLYQLRDQIHDNPTLNGVGVKQIIDSVIDVDETVIHPKEDAVRPEGGIAILTGNLTPDGAVVKQSGVSEKMMTFEGTARCFNSEEEAMQALMGGQVKAGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALITDGRFSGGTRGPCVGHVSPEAAVGGPIALVEDGDTIVLDIPSRRLEVKVSDQELAKRRERWQAPEPKIKKGWLSRYASVVTSANTGAVCKAR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CDX1_MOUSE
Sequence: MYVGYVLDKDSPVYPGPARPSSLGLGPPTYAPPGPAPAPPQYPDFAGYTHVEPAPAPPPTWAAPFPAPKDDWAAAYGPGPTASAASPAPLAFGPPPDFSPVPAPPGPGPGILAQSLGAPGAPSSPGAPRRTPYEWMRRSVAAAGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPLPPTQLPLPLDGTPTPSGPPLGSLCPTNAGLLGTPSPVPVKEEFLP
What is the function of this protein?
Plays a role in transcriptional regulation.  Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells.  Binds to the PRKD1 promoter in colorectal cancer (CRC) cells.  Could play a role in the terminal differentiation of the intestine.  Binds preferentially to methylated DNA.
What are the official names of this protein?
Homeobox protein CDX-1, Caudal-type homeobox protein 1.
What is the protein family that this protein belongs to?
Belongs to the Caudal homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS15_SHESM
Sequence: MSLSTEAKAKILAEFGRGANDTGSTEVQVALLTAQINHLQDHFKEHIHDHHSRRGLLRMVSARRKLLAYLKRTEAARYNELIQKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RL30_LACLA
Sequence: MAQIKITLVNSPIGRIPAQRKTVKALGLGKLNSSVVKEGSPAILGMVNSISHLVKVEEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: C1GTB_DANRE
Sequence: MKALGARSAFYVGFLVGTCSLYLLLRQAGFTRDSGSREPGTHDKTLLEMLEEENKNWKKERSALFNLNHPHHTGEDGALADSLYKRVRILCWVMTGPDNLEKKARHVKATWSRHCNIVVFISSVDNPDFPTVGLNTKEGRDQLYWKTIRAFHYVMEKHSDEADWFLKADDDTYVIVDNLRWILARHSPEDPVYFGRRFKPYVKQGYMSGGAGYVLSKEALRRFVEGFRTKVCTHTTSVEDLAMGQCMEKIGVKAGDSRDTMQRETFHPFVPESHLTGTFPKTFWYWNYCYYPIVQGPQCCSDLAVSFHYVDASHMYLLEYYTYHLRAFGYKYRYQPPEPNVKAPEKVETRVLEQKDKVEAQEEENQSPELNDKL
What is the function of this protein?
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
What are the official names of this protein?
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B, Core 1 O-glycan T-synthase B, Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B, Core 1 beta1,3-galactosyltransferase 1-B, C1GalT1-B, Core 1 beta3-Gal-T1-B.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: SYE1_ALIB4
Sequence: MAITRFAPSPTGYLHIGGLRTSLYSYLWARKTGGEFRLRIEDTDLARNSEEAMKAIIDAFDWVGLNYDGEVFYQSKRTDIYKQYIDKLLESGNAYKCYMSKEELDALRAAQEAAKQTPRYDGTWRPEPGKELPPVPAGVEPVIRIKAPTTGTIEFDDGVKGHMKFDANQVDDYVIARSNGMPTYNFVVAIDDALMGMTDVIRGDDHLSNTPKQIVVYNALGFKVPKFYHVPMINNPEGKKLSKRDGAMDVMDYKRLGYLPEALLNFLVRLGWSNGDQEIFSMKEMLELFDPSNINKSASSYNGEKLLWLNSEYIKAVSNERLIEELKFFDLDLSNYPKKNEILDLAKQRAQTLVELKKSITDIIDIPTSYEESGVKKFIKEDTKELLEKYLLLLESNKNSLDSVEKIEEFTKPFINDNGLKFPQLFQPIRIALTGGTQAPSVYDIIFILGYDEIFKRINEALKRNFQNT
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_STAAM
Sequence: MTTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGIRPGRSFDKAKEDGFDVFPVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIHFGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQDASGQARNIALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSKLIQSGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEGGMENVRYSISNTAEFGDYVSGPRVITPDVKENMKAVLTDIQNGNFSNRFIEDNKNGFKEFYKLREEQHGHQIEKVGRELREMMPFIKSKSIEK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: YB95_ARATH
Sequence: MALAWCVVRRSASKFASVYGGRVRSISAVANRASLARNPSSIRPFVSRALNYSTAIDRISSEQTLIRVIDSEINSALQSDNIDSDEEMTPGSFPFRIEDKPGNQNVTLTRDYNGEHIKVVVSMPSLVSDENDDDDDDDEGPSNESSIPLVVTVTKKSGLTLEFSCMAFPDEIAIDALSVKHPGDSLEDQLANEGPDFEDLDENLKKTFYKFLEIRGVKASTTNFLHEYMTRKVNREYFLWLKNVKEFMEQ
What are the official names of this protein?
Uncharacterized protein At2g39795, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the MAM33 family.
Protein: YWFA_BACSU
Sequence: MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDLAKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICALAQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVPLGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDALKVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVITGKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTILSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLSVFAYKKYGKLEQKADQSLSQ
What are the official names of this protein?
Uncharacterized MFS-type transporter YwfA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS4_BACVZ
Sequence: MNAFTLYPAIDMRNGKCVRLIQGDYGKETIYGDSPLDMAAQFAQEGAEWIHLVDLDGAKAGRKVNDRHVLDIARQLDAKVEIGGGIRSEADVYGYLSQGVDRVILGSSAVSDPAFVKSMLKQYGGKIAIGLDARNGYVSTEGWLETSSVRAADLGRELAAEGAETFIFTDIATDGMLSGPNIESTVQLAKATGKTVIASGGVSSVADLKALARFKDAGVSGAIIGKALYTKQFTLAEALSGVKDA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCG4_HUMAN
Sequence: MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGTNLTMDDGPPPRRARGDLTHSGLWRVCCIEGIYKGHCFRINHFPEDNDYDHDSSEYLLRIVRASSVFPILSTILLLLGGLCIGAGRIYSRKNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDKRDEDKKNHYNYGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKTKREFLKASSSSPYARMPSYRYRRRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLSREPLKVTTAASYSPDQEASFLQVHDFFQQDLKEGFHVSMLNRRTTPV
What is the function of this protein?
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204).  Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4.  Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611).
What are the official names of this protein?
Voltage-dependent calcium channel gamma-4 subunit, Neuronal voltage-gated calcium channel gamma-4 subunit, Transmembrane AMPAR regulatory protein gamma-4, TARP gamma-4.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUSB_SALPA
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLSGVATNSAYLDGLMKPYLSRLLEELGQVEKAVLRIALFELSKRSDVPYKVAINEAIELAKTFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PRIC1_MOUSE
Sequence: MPLEMEPKMSKLVFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLQMNGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSVRMGRSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDVSLASRQGAGFANEEFWKARVEQEASEDPEEWAEHEDYMTQLLLKFGDKNLFQQQSSEVDPRASEHWIPDNMVTNKPEVKPNHQGLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGAAGYTHDQSQWYEDSLECLSDLKPEQSIRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIEAEDCEKMSNMGTLNSSMLHRSAESLQSLNSGLCPEKILPEEKPAHLPVLRRSKSQSRPQQVKFSDDVIDNGSYDIEIRQPPMSERTRRRAYHFEERGSRPHHHRHRRSRKSRSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQNKSARELQAYMQNANLYSQYAHATSDYALQNPGMNRFLGLCGEDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDLSSPASALPTPQFTQRTTKSKKKKGHKGKNCIIS
What is the function of this protein?
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity).  Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis.  Necessary for nuclear localization of REST.  May serve as nuclear receptor (By similarity).
What are the official names of this protein?
Prickle-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the prickle / espinas / testin family.
What are the subcellular locations of this protein?
Nucleus membrane. Cytoplasm, cytosol. Note=A smaller amount is detected in the cytosol.