PharMolix/UniProtQA huggingface dataset:
Protein: TCM62_YEAS7
Sequence: MLRNCLRKLGNHQTKCSVKTLHTPIYRTKNLQVLRDTLSGIKLLEKIITSSSYNKTLIYEPKYKSKPQVVSSHDTMRLHNVMRELLDSLQVDEATNTRLQSNRPRKLGRVGLQLFMDCIQDNLTATSTSLTCSLLEHYFKYPEKEVTNGIKAGLRYIRDFLAKNKIIVKSQNDVDALVEQLTMSSSDSQSIKRVLKAINYELFSDDIVRVINGNKTYDEVDVSKGWKYPAGILDSNEAYLRSLELPTKKLVSIDKDMLVLMYDGTLRDANKILPTITYARKLRKSILLIVNGDCTGDALTSVTINNNRNKRENNESRIVVLKYSKKANNDLAPQENLDFIKFLRLPCGYDSIYSPEYSPLVPSKMCADKYYGSIESIKATTGEAFLYNSIDAEAIPNKVPKSFLQNTVTLSIGGHNEIEIDRRRNAIDNCLNNVLCHGLAKGFIPGYGISLLKAIPGLNELKANEPNFMTKVGINAVLSAVILPSEVAFKNAYGYNYYEINSLIAGAINEKSFPMAKFSPNSEPVNTVKDGNLEPWSKMDSCLAGVETFIELLTSCNTIITCVYKKPERHKA
What is the function of this protein?
Chaperone.  Required for the assembly of succinate dehydrogenase subunits.  Ensures mitochondrial gene expression at elevated temperatures and prevents heat-aggregation of the ribosomal subunit VAR1 (By similarity).
What are the official names of this protein?
Mitochondrial chaperone TCM62.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: CBIG_METJA
Sequence: MMIKIVYITKRGKKIAEEIKDVLDYYHYDNKVEPIKDFKIERNEGGFIFIMATGIVLRKFLDEIKNDKFKDPFVIICNENKELIPILSNHLGGGNYFSKLIANNINGRVIFTTATDVNGKVGIDELSKMLFLETPKRKHILDINKKILEEDVSLTLPKYWKLRNLNGYKISYHDKYEVVVDDSIRLKPLKIAVGLGARKGIERYKVYWAVKKALFLRNIPVWRVDAFATIEDKKHERGILETVNKFKKPLIIFKREEINEIYEKIDLEKSEFVYKHLGVYGVSEPASILAVKKLTNKDFDSIKLILKKFKRNGVTVAIATENL
What is the function of this protein?
Catalyzes the hydrolysis of the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde.
What are the official names of this protein?
Probable cobalt-precorrin-5A hydrolase.
What is the protein family that this protein belongs to?
Belongs to the CbiG family.
Protein: ZBT10_RAT
Sequence: MGPGRRGNGIGGPGAPRLGGLRRGGRRGGRQGVAAPLGHGRPRLAGRRRGGPPASGKEPSDSGLPRGRRRGSRQQWQQSRPPGDLGVAPQAFQWARAGGRGSGAGRAGGEGVDAGRGVPELQHRGGGGEPGRWQWGGRRQRSSSRRSGGEGGEEAEGSGVGAGEGETVQHFPLARPKSLMQKLQCSFQTSWLKDFPWLRYSNDTGLMFCGWCQTTPEDVGSVDLPQVGHDELSRGTRNYKKTLLLRHHVSTEHKLHEANAQVLGSQACVTVDGSAVDKPDASEGCLLVGNESEIPSEEGYCDFNSRPNENSYCYQLLRQLDEQRKKDILCDVSIVVSGKIFKAHKNILVAGSRFFKTLYCVSNKESPNQNNTTHLDIAAVQGFSVILDFLYSGNLVLTSQNAIEVMTVASYLQMSEVVQTCRNFIKDALNISIKSEAPESVVVDYNNRKPVSRDGLTSSRDQKIASFWATRNLTNLASNIKIENDGCNVDEGQIENYQMNDSNWVQDGSPELAENESQGKTKVFIWNNMASQETGKARRKNQTTKRFVYNIPPNSETIVEDCSVLQPPVAYPEENKALLIKEEPVSDLDGALLSGPDGDRTMNTNLLAEACSSQDAGDAAGASHDFKYGLMPGTSSDFKYGLLPSTSNDFKYGLLPGAPNDFKYGLLPESWPTQEPWENGDSSLIMNKLKCPHCSYVAKYRRTLKRHLLIHSGVRSFKCEICGKMFTRREHVKRHSLVHKKDKKYKCMVCKKIFMLAASVGIKHGSRRYGVCMDCVDKSQPGGQESIDQGQDTEFPRDEEYEENEGVEPDEELAEDGQDQSDAPRWDEPGGAYVSG
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 10, Zinc finger protein RIN ZF.
What are the subcellular locations of this protein?
Nucleus.
Protein: HM01_CAEEL
Sequence: MRRARTAFTYEQLVALENKFKTSRYLSVVERLNLAIQLQLSETQVKIWFQNRRTKWKKHNPGQDANTPQTPPSSDETQIQPILPANPITSFSSLLLPPIISPANSAVLQGTSIPLTLFNLNQILMPQNVGFN
What are the official names of this protein?
Homeobox protein ceh-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RK14_OSTTA
Sequence: MIQPQTYLEVADNSGARKLMCIRVLNRKIGHIGDVIIAVVKEALPNMPIKKSEVVRAVIVRTAHTIQRDNGMSIRFDDNAAVIINKEGNPRGTRVFGPIARELRERDFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HBA_EQUPR
Sequence: MVLSAADKTNVKAAWSKVGGHAGEFGAEALERMFLGFPTTKTYFPHFDLSHGSAQVKAHGKKVGDALTLAVGHLDDLPGALSNLSDLHAHKLRVDPVNFKLLSHCLLSTLAVHLPNDFTPAVHASLDKFLSSVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: MIAA_NITMU
Sequence: MKKKTGYSPYPPAIFLMGPTASGKSALALHIARYLPVEIISVDSAQVYRHMNIGTAKPGPEALAATPHHLIDLIDPHEHYSAARFRTDALRTMREIADRGSIPLLAGGTMLYFKTLLEGLSELPSADSDVRAAIEAKARKSGWPAMHQELFRLDSVSAERIKPTDSQRIQRALEVFYLTGKPMSETLRKPKNVSLPYEVVKIALVPGNRQALHQRIACRFEQMLKHGLIDEVRAIRDKFYLSDENPSMRCVGYRQVWMHLENATDALRMREMALAATRQLAKRQLTWLRSMKETREFDCLQENLPEQVKTYLLNTGLKFTEVS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: CH10_BACP3
Sequence: MLKPLGDRIVIEVVETEEKTASGIVLPDTAKEKPQEGRVVAVGAGRVLDNGQRIGRKSKVGDRVIFSKYAGTEVKYDGKEYLILRESDILAVIR
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10, Heat shock 12 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRB_NEIMA
Sequence: MGLKHFLEKIEPHFLPGGKHEKWYALYEAAATIFYTSGAVTRKAAHVRDALDSKRMMILVWLALFPAMFYGMYNVGAQAFGALTPDLLQQSIANDWHYALANALGINMSSEAGVLGKMLFGAIYFLPIYATVFIVGGFWEVLFATVRKHEINEGFFVTSILFALIVPPTLPLWQAALGISFGVVVAKEVFGGTGKNFMNPALAGRAFLFFAYPANLSGDAVWTAVDGYSGATALAQWAAHGADGLKNAITGQTITWMDAFIGKLPGSIGEVSTLALLIGGAFIVFARIASWRIIAGVMIGMIAMSSLFNFIGSDTNAMFAMPWYWHLVVGGFAIGMLFMATDPVSASFTNVGKWWYGALIGVMCVLIRVVNPAYPEGMMLAILFANLFAPIFDYFVAQANIKRRKARSNG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit B, Na(+)-NQR subunit B, Na(+)-translocating NQR subunit B, NQR complex subunit B, NQR-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VATD_STRSV
Sequence: MTRLNVKPTRMELNNLKARLKTAVRGHKLLKDKRDELMRRFIESVRENNQLRQKVESALVGHLQDFVMAKALESDLMVEEIFAVPTREVNLHVETENIMSVRVPKMHAHIDNPHTDDEGDVVYSYVASNSQMDETIESMSDLLPDLLRLAEIEKSCQLMADEIEKTRRRVNGLEYATIPDLKETIYYIEMKLEEAERASLVRMMKVK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: RL22_ECOLU
Sequence: METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: Y877_BURPS
Sequence: MDARLLEILVCPICKGPLHYDRGAQELVCHADKLAYPIRDGIPVMLVDEARQTVEGTPVDPAGPARGR
What are the official names of this protein?
UPF0434 protein BPSL0877.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: T4HR_MAGO7
Sequence: MPAVTQPRGESKYDAIPGPLGPQSASLEGKVALVTGAGRGIGREMAMELGRRGCKVIVNYANSTESAEEVVAAIKKNGSDAACVKANVGVVEDIVRMFEEAVKIFGKLDIVCSNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFVAREAYKHLEIGGRLILMGSITGQAKAVPKHAVYSGSKGAIETFARCMAIDMADKKITVNVVAPGGIKTDMYHAVCREYIPNGENLSNEEVDEYAASAWSPLHRVGLPIDIARVVCFLASNDGGWVTGKVIGIDGGACM
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 1,3,6,8-tetrahydroxynaphthalene (T4HN) into (+)-scytalone and 1,3,8-trihydroxynaphthalene into (-)-vermelone.  This enzyme is the biochemical target of several commercially important fungicides which are used to prevent blast disease in rice plants.
What are the official names of this protein?
Tetrahydroxynaphthalene reductase, T4HN reductase, THNR.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: VATG3_XENLA
Sequence: MASQSQGIQQLLQAEKRAKDKLEEAKKRKNKRLRQAKEEATADIDQYRLKREADFRRIQTSVMGSQGNLAVKIEEQTVEKIQFYSSSYNKYKEGVLKELLDLAYNIKPELHTNYKYKI
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons.  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
What are the official names of this protein?
V-type proton ATPase subunit G 3, V-ATPase subunit G 3.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase G subunit family.
Protein: GPPUS_KLEPN
Sequence: MTISQHRFRSNANASIISMLQRFSDILIIFLGIYFSCFINDYFFNLHYVLMALVALVVFQMIGGITDFYRSWRGVEFSVELILILKNWSLSFLLTLGFVTLFSDFDLTFRTFIFWYLAVCAGFVVTRPLIRALAGFFRRIGYNKRRVAFAGSLPAGISLLETFRKQPWLGFEVKGIYEDSFSGTYDLELYAGKISDLINEARKGTIDRIYIAMHMRDEVAIKNMVSQLTDTTCSVLYIPDVFTFNILQSRTEEINGVPVVPLFDSPLNGINMVFKRLEDIIVSSLILILISPILLVIATAVKTTSKGPVIFRQVRYGMDGKPIKVWKFRSMTVMENDDKVIQATKNDIRVTKVGKFLRSTSLDELPQFFNVLFGQMSVVGPRPHAVSHNEQYRSLIQGYMLRHKVKPGITGLAQINGWRGETDTLEKMEKRIEYDLLYIRGWSIWLDLKIIFLTVFKGFINKSAY
What is the function of this protein?
Is likely the initiating enzyme for the K2 capsular polysaccharide synthesis.  Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl-pyrophosphoryl-undecaprenol (Glc-PP-C55) (By similarity).
What are the official names of this protein?
UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase, UDP-Glc:Und-P Glc-1-P transferase, Capsular polysaccharide biosynthesis lipid carrier glucose-1-P transferase, Glucosyl-P-P-undecaprenol synthase, ORF14.
What is the protein family that this protein belongs to?
Belongs to the bacterial sugar transferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CD4_HUMAN
Sequence: MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
What is the function of this protein?
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508).  Down-regulated by HIV-1 Vpu (PubMed:17346169).  Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).
What are the official names of this protein?
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV- 1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Protein: PSD_BRUAB
Sequence: MSLTDTIRNTFVPIHREGYPFIAGFFVVSLILGWLWDPLFWIGMVLTVWCIYFYRDPERVTPMDDDLVISPADGKVSFVGLAVPPAELDLGYEPMTRVSVFMNVFSVHINRSPVRGKIDKVVHRPGKFLNAELDKASTENERNSVLIESPHGKIGVVQIAGLVARRIVCWSNQDDELSVGERFGLIRFGSRVDVYLPSDATVRVAVGQTAIAGETVLADYGTERGEPVVRIA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LOGH_MYCTU
Sequence: MSAKIDITGDWTVAVYCAASPTHAELLELAAEVGAAIAGRGWTLVWGGGHVSAMGAVASAARACGGWTVGVIPKMLVYRELADHDADELIVTDTMWERKQIMEDRSDAFIVLPGGVGTLDELFDAWTDGYLGTHDKPIVMVDPWGHFDGLRAWLNGLLDTGYVSPTAMERLVVVDNVKDALRACAPS
What is the function of this protein?
Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis.  Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M. tuberculosis lysates and supernatants.  Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo.  Accumulation of Rv1205 sensitizes M. tuberculosis to nitric oxide since cytokinin breakdown products synergize with NO to kill M. tuberculosis.  Shows a slow AMP hydrolase activity, but is not able to hydrolyze ATP.  Displays no lysine decarboxylase (LDC) activity (L-lysine conversion to cadaverine).
What are the official names of this protein?
Cytokinin riboside 5'-monophosphate phosphoribohydrolase, Protein LONELY GUY homolog, LOG homolog.
What is the protein family that this protein belongs to?
Belongs to the LOG family.
Protein: RS4E_PYRCJ
Sequence: MVHLRKSLAPYWWPIPRKAGGVWAVRPSTGPHSLEYSLPLAVVVRDVLRYAKTLREARYIISRGYIKVDGVVRKDYKFPIGLMDVVEIVPTGEIYRVVPDEAKYYDLKPIPSSEAALKPLRVEGKTAVSGGRIQLHFHDGRNLILPPDVGRQIKTFDTVVYDLENKAIKTHLPLRLGQLAVVTHGGNIGFVGQFFEVVWTLKRRQSVVALRKGEEVRRTILDYIMVIGTEAPVVKIS
What are the official names of this protein?
30S ribosomal protein S4e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: PRP2_GALME
Sequence: MTDRVKSLQLLFDRPNEPLITPKGENGAIFQLTQDLLPVDYEDNGIALNNRFGEEADEKIPLKPLSNPPQFPIASQLPTDADFSLFLPRHQEMATEVIDVLMNIPENQLDDLLSSCVYARGRLNPQLFNYCYSVVLMHRRDTRNVPIQNFAETFPSKFLDSQAFAQARETAAVFPRGIPRTPIIIPRDYTATDLEEEHRLAYWREDIGINLHHWQWHLVYPFTASDRSIVAKDRRGELFFYMHQQIIARYNCERINNSLKRVKKFNNWREPIPEAYFPKLDSLTSSRGWPPRQANMTWQDLNRPVDGLNVTISDMERWRRNLEEAVSMGTVTLPDGSTRPLDIDTLGNMVEASILSPNRELYGSVHNNGHSFSAYVHDPSHRYLENFGVIADEATTMRDPFFYRWHAWVDDLFQKHKESNFVRPYSRSELENPGVQVTSVSVETQGSPQNVLSTFWMSSDVDLSRGLDFSNRGPVYARFTHLNHRPFRYVIKVNNSGNARRTTVRIFISPKFDERNLAWSLVDQRKMFIEMDRFVTPLKAGENTITRQSTESTFTIPFEQTFRDLSVQADDPRRVDLAAFNFCGCGWPQHMLVPKGTEAGAPYVFFVMLSNYDLDRIDEPGNSPEISCKEASSFCGLRDRKYPDKRAMGFPFDRPSRTATSIEDFILPNMALQDITIRLNNVVEANPRNPRT
What is the function of this protein?
Copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity).  Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone (By similarity).  Binds to the surface of hemocytes and is involved in hemocyte melanization (By similarity).  Binds the A. niger cell wall component alpha-1,3-glucan, a fungal pathogen-associated molecular pattern (PAMP) that activates the host immune response (PubMed:34443685).
What are the official names of this protein?
Phenoloxidase subunit 2, Prophenoloxidase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in the hemolymph.
Protein: SCX3_CENLI
Sequence: MNSLLMITACLAVIGTVWAKEGYIVNYYDGCKYACLKLGENDYCLRECKARYYKSAGGYCYAFACWCTHLYEQAVVWPLPNKTCYGK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Toxin Cll3.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RNFE_ALIF1
Sequence: MASHKELVKNGLWDNNPALVQLLGLCPLLAVSATVTNALGLGIATILVLVGSNLIVSLVRQWIPQEVRIPVFVMIIASLVTCVQLLMNAYAYGLYLSLGIFIPLIVTNCIIIGRAESFASKNDPLPAVLDGLWMGMGMTAVLVLLGAMREILGNGTLFDGADLLLGDWATMLRIELFHVDSHFLLAMLPPGAFLGVGFLIALKNVIDKKMADRQPKEKAEIERARIS
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rnf electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FAXD_CRYNI
Sequence: MAPPLLLCLILTFLWNLPEAESNVFLKSKVANRFLQRTKRSNSIFEEFKAGNIERECIEEKCSKEEAREVFEDNEKTETFWNVYVDGDQCSSNPCHYRGTCKDGIGSYTCTCLPNYEGKNCEKVLFESCRVFNGNCWHFCKSVQNEIQCSCAESYRLGDDGHSCVAEGDFSCGRNIKARNKREASLPDFVQSQKAILLKKSDNPSPDIRIINGMDCKLGECPWQAVLLDEDDDVFCGGTILSSIHVLTAAHCINQTKNISVIVGEIDISRKETIRLLPVDKVYVHTKFVPPSYLYGHQNVDRKTYDYDIAIIRMKTPIQFSENVVPACLPTADFVKQVLMKQDFGIVSGFGRTQYRGQTSNTLKVITVPYVDRRTCMLSSDFPITPNMFCAGYDTLPQDACQGDSGGPHITAYGDTHFITGINSWGEGCAKKGKYGVYTKVSNFIPWIKAIMSLK
What is the function of this protein?
Snake prothrombin activator that attacks the hemostatic system of prey.  This protein is functionally similar to blood coagulation factor Xa (By similarity).
What are the official names of this protein?
Venom prothrombin activator nigrarin-D, vPA, Venom coagulation factor Xa-like protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HRCA_STRCO
Sequence: MLSERRLKVLRAIVQDYVGTEEPVGSKALTERHNLGVSPATVRNDMAALEDEGFIAQPHTSAGRIPTDKGYRLFVDKLAGVKPMTAPERRAIQNFLEGAVDLDDVVARTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAPARLMLVLITDTGRVEQRMVDCPAPFGEASLADLRARLNSRVAGRRFADVPALVEDLAEPFEAEDRGTVSTVLSTLLETLVEENEERLMIGGTANLTRFGHDFPLVIRPVLEALEEQVVLLKLLGEAKDPGVTVRIGHENAHEGLNSTSVVSVGYGSGGEAVAKLGVVGPTRMDYPGTMGAVRAVARYVGQILAES
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: LPXA_BURO0
Sequence: MTRIHPTAIVEPGAQIDESVEIGPYAIVGPHVTIGARTTIGSHSVIEGHTTLGEDNRIGHYASVGGRPQDMKYKDEPTKLVIGNRNTIREFTTIHTGTVQDVGVTTLGDDNWIMAYVHIGHDCRVGNNVILSSNAQMAGHVEIGDFAIIGGMSGVHQFVRIGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSADAISALRSAYRVLYKNGLSLEEAKVQLRELAEAGGDGDAPVTALVEFIDASQRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
Protein: CPXCR_HUMAN
Sequence: MSYPTKEGSDTAGNAHKNSENEPPNDCSTDIESPSADPNMIYQVETNPINREPGTATSQEDVVPQAAENSELETEIQKDQREEDLKEELLLLQTPIPRKLVSHKPLNDRSRSHSGKVEMKANNFPINHKTRFRLSTSWRVPFINSHEIRSMILHLLCDRYFSQAAGCQNTMWVKRKYIACLYHPNSFTHHERAITFRRPSRVHYYRPLTERMTSGKFCKSTDTKGKCRFRAIVRSVLFVSQIQIESIFNIKGFVDILTYIHTMNVMITNTNNGWKYFCPICGRLFNTYSELRQHSCSSSGN
What are the official names of this protein?
CPX chromosomal region candidate gene 1 protein, Cancer/testis antigen 77, CT77.
Protein: RNFA_HAEDU
Sequence: MVDYILLVISTALINNFVLVKFLGLCPFMGVSKKVETAIGMGMATTFVLTLASLSAYLVERFILIPLDAQFLRTLVFILVIAVIVQLTEMIVHKTSPTLYRLLGIYLPLITTNCAVLGVALLNVNLSNNLIESVLYGFGAAVGFSLVLVLFAALRERLAAADVPRPFQGASIALITAGLMSLAFMGFTGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DUOX_DROME
Sequence: MSVPSAPHQRAESKNRVPRPGQKNRKLPKLRLHWPGATYGGALLLLLISYGLELGSVHCYEKMYSQTEKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGANRPSTRRLSRLFMRGKDGLGSKFNRTALLAFFGQLVANEIVMASESGCPIEMHRIEIEKCDEMYDRECRGDKYIPFHRAAYDRDTGQSPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGTLLTEKDGKLPVRNTMRVPLFNNPVPSVMKMLSPERLFLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLGTSLPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRDGQCNFKETPMGYPAVRLCSTWWDSSGFFADTSVEEVLMGLASQISEREDPVLCSDVRDKLFGPMEFTRRDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDVYVGGMLESYGQPGEFFTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTDVKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGYDYFSGSELMFIYVCVFLGFVPILCAGAGYCVVKLQNSKRRRLKIRQEALRAPQHKGSVDKMLAREWLHANHKRLVTVKFGPEAAIYTVDRKGEKLRTFSLKHIDVVSVEESATNHIKKKPYILLRVPSDHDLVLELESYGARRKFVKKLEDFLLLHKKEMTLMEVNRDIMLARAETRERRQKRLEYFFREAYALTFGLRPGERRRRSDASSDGEVMTVMRTSLSKAEFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTNVARMTSFNIEPMQDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKTRKLPYFIHHFENFG
What is the function of this protein?
Plays a role in innate immunity limiting microbial proliferation in the gut (PubMed:16272120, PubMed:25639794).  Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).  May generate antimicrobial oxidative burst through its peroxidase-like domain (PubMed:16272120).
What are the official names of this protein?
Dual oxidase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the peroxidase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.