PharMolix/UniProtQA huggingface dataset:
Protein: LYS7_ECOLX
Sequence: MKKITGIILLLLAAIILAACQANYIRDVQGGTVSPSSTAELTGVETQ
What is the function of this protein?
Lysis proteins are required for both colicin release and partial cell lysis.
What are the official names of this protein?
Lysis protein for colicin E7.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RSMI_LEPBL
Sequence: MKKELQGALVLVSVSLGNFGDLTARARHLLEYCDILIGEEFRTTSTLLKSLSISKQFLLCNEHTTPEEIRSLGQIVVDSGLTVLVSDAGTPGIEDPGRELVGEVLRRGGRVQSAPGPIAFGAALSISGFKTSPFTFCGFLSRDSSERKLELSRYLKPGHTVVFYETPYRYKAVLRDLDSVLIETGEDRAIFFCLDLTLDSEFQFRGKLGELLKVLDTLPKGNPVIVVSQRKEQRSQRSFSKGDKKPSFKRFKK
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_BRUMB
Sequence: MLKKLKDYRRIVVKIGSALLVDRATGLKREWLESLGQDIAALQHAGVEVLVVSSGAIALGRTVLGLPKKALKLEESQAAAAAGQIALAKAYADVLGGHGIKSGQILVTLSDTEERRRYLNARATIETLLKLKAVPIINENDTVATTEIRYGDNDRLAARVATMMGADLLILLSDIDGLYTAPPHKNPDAQFLPFVETITPQIEAMAGAAASELSRGGMKTKLDAGKIANAAGTAMIITSGTRFGPLSAIDRGERATLFEAAHAPVNAWKTWISGNLEPAGRLTVDAGAVKALKSGKSLLPAGVKEVDGDFERGDTVAVMNEDGREIARGLIAYDAADARKVAGHKSDEISAILGYDARAAMIHRNDLVVRAASDAKAA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y336_STAEQ
Sequence: MKTNVIIDGDACPVVNSVIELTKGTGIFVTILRSFSHFSQQIQPEHVKIVYVDDGPDAVDYKIVELASNNDIVITQDYGLASLLIDKVHTVMHHKGNIYHSNNIQSLLNQRYLNAQIRRRGGRHKGPPPFTTEDRLKFEHAFRKIINQI
What are the official names of this protein?
UPF0178 protein SERP0336.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: RAP94_VARV
Sequence: MDSKETILIEIIPKIKAYLLDANISPKSYDDFISRNKNIFVINLYNVSAITEEDIRLLYTTIEQNIDANDQTLVAIFSYIGYKFEQTVKEEISTSLSLNDKNTTDEMTYNLYDLFFNTLDMYLRQKKISILVNDDVRGDVIVSYKNSDLVSSFNAELEPEIKKIPFNMKNLLPYLEKNLDQLRFSKKYLDFAYLCRHIGIPISKKKYNVRYVFLYKIDGLSIPIIIKDFLDVKYVYLENTGKIYKNSFSEDHNNSLSDWGKVIIPLLKDRHLYSYIFLSSYHLHSYYTDLIAKDEPVFIKRKKLDIIEIDEPEAWKRDVKVEFAPCEHQIRLKEAMKVDANYFTKINNFANEFIYYEDGVAYCRVCGINIPIFNLDAADVIKNTVIVSTFNKTIFLSEPYSYFVHSQRFIFNIIMSFDNIMKSQTWVMKYNINRLILNFFIDINSRRQEYEKKFSSEIKRGLFFLRLSANLFESQVSSTELFYVSKMLNLNYIVALVIILNSSADFIVSYMKSKNKTVEESTLKYAISVVIYDFLVKTRICEKGSLDTIVLFTDVYTSIMPEELDLHFQRITLELRKLVSIQRSALEPNYDVESRGEELPLSTLKFFDTSTIIVKTMAPVHTYVEQKIVAPTPSVEPTDASLKQFKELTCDEDIKILIRVHDTNATKLVIFPSHLKIEIERKKLIIPLKSLYITNTLKYYYSNSYLYIFRFGDPMPFEEELIDHEHAQYKINCYNILRYHLLPDSDVFVYFSNSLNREALEYAFYIFLSKYVNVKQWIDENITRIRELYMINFNN
What is the function of this protein?
DNA-directed RNA polymerase-associated factor required for the transcription of viral early genes as well as for transcription termination.  Within minutes after virus entry, recruits the core RNA polymerase, the early transcription factor (ETF) and other enzymes needed for transcription initiation, elongation, and termination thereby allowing synthesis of early mRNAs which are extruded through pores in the core particle.  Recruits the multifunctional OPG102 protein, with poly(A) polymerase-stimulatory, cap nucleoside-2'-O-methyltransferase, and transcription elongation activities.  Interacts with nucleoside triphosphatase I/OPG123, a DNA-dependent ATPase required for the termination of early transcripts.  Acts as a transcription termination factor by binding, together with the capping enzyme/VTF, to the termination motif 5'-UUUUUNU-3' in the nascent mRNA.  Involved as well in the packaging of RNA polymerase and other components needed for early transcription in assembling virus particles.
What are the official names of this protein?
RNA polymerase-associated transcription-specificity factor RAP94, Protein H4, RPO-associated protein of 94 kDa.
What is the protein family that this protein belongs to?
Belongs to the poxviridae protein RAP94 family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome.
Protein: ACCD_ECO24
Sequence: MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVELGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLYGMPVVAAAFEFAFMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLMNLPAPNPEAPREGVVVPPVPDQEPEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_AZOVD
Sequence: MQYKLTRIDPDASYEQYPIGERETVTDPSEGQVHRNIFMGKLEDVLSGAVNWGRKNSLWPYNFGLSCCYVEMTTAFTAPHDIARFGAEVIRASPRQADFMVIAGTCFIKMAPIIQRLYEQMLEPKWVISMGSCANSGGMYDIYSVVQGVDKFLPIDVYIPGCPPRPEAFLQGLMLLQESIGQERRPLSWVVGDQGIYRAEMPSQRELRREQRIQVTNLRSPDEV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LY75_MESAU
Sequence: MGTRRVTPGCAAGLLVLLLRCFGLAEPSEFSGDDSFTIVNENTGKCIQPLSDWIVAQDCSETRSMLWKWVSQHRLFHLESQKCLGLDMTKAADNLRMFRCDSSVLLWWKCEHHSLYSAAHYRLDLKDGYATASTNSSAVWKKGGSKENLCDQPYREIYTRDGNSYGRPCEFPFLVGETWHHDCIRDENHSGPWCATTLNYEYDQKWGICLKPESGCEGNWEKNEQIGSCYQFNNQEVLSWKEAYVSCQNQGADLLSIHSAAELAYITGKEDIARIVWIGLNQLYSARGWEWSDFKPLKFLNWDPGTPSAPMIGGSSCARMDTETGLWRSVSCEAQQPYVCKKPLNNTVELPDVWTYSDTHCDVGWLPQNGFCYLLANESGPWDAAHLKCKAFGGDLISIHSLADVEVVVTKLHSGDVKEEIWTGLRNVNSPTLFQWSDGTEVTLTYWNENEPSVPYNKTPNCVSYLGKLGQWKVQSCEKKLRYVCKKKGEITNDTRSDKLCPPDEGWKRHGETCYKIYENEVPFGTNCNLTITSRFEQEFLNDMMKKYDKSFQKYFWTGLRDADARGEYSWAATGGLKQAMTFSNWNFLQPASPGGCVAMSTGKTLGRWEVKSCRSFRALSICKKMSGPQEPEEATPKPDEPCPEGWHTFPSNLSCYKVFHIERTVRRRTWEEAERFCQALGAHLPSFSHMNEVKEFLHLLQDQFSVQRWLWIGLNKRSPDLQGSWQWSDRTPVSTVIMHREFQQDYDVRDCAAIKVLDNAWLRTWYYYDERKFGYLKPFSCDAKLDWVCQIPKGSTLQVPDWYNPERTGIHGPPVIIDGSEYWFVEEPRLNYEEAVLYCASNHSFLATITTFTKLKAIRGKMENLSGEEQKWWVKANANPIDHYFLRTRPLWHRFSMLLDEECLQMSAKMWHLDLNKRADCNDKLPFVCEKYNVSSLEKYSPDSAAKVQCTGKWIPFQNKCFLKVKSEPVTFSQASSTCHTYGGTLPSVLSKSEQDFIISLLPEMETSLWIGLRWTAYDRISKWTDGRNLTYSNFHPLLVGRRLSIAAYFIDEESHYHCALMLNLRKSPLTGTWNFTSCSERHSLSLCQKYSENEDGRPWETNSETVKYLNNLYKIISKPLTWHGALKECLNENMRLVSITDPYQQAFLSVQATLRNTSFWIGLSSQDDELNFGWSDGTYLHFSNWAVDNEKLDDCVILDTDGFWKTADCDENQPGAICYYPGNETSKEVRPLNSAKCPSPAQSTPWVPFQNSCYNFMITKNRHRTITQKEVHSLCQKLHSKAQILSIRNEEENNFVVEQLLYFNYIASWVMLGVTYENNSLMWFDKTALSYTHWRAGRPAVKNHKFLAGLSTDGFWDIQSFNVIDETLHFYQHSILACKIEMVDYKEERNSTLPEFIPYEDGVYNVIQKRVTWYQALSMCSQSGRHLASVHNPKEQLFLEDIVNRDGFPLWVGLSSHDGSESSFEWSDGSAFDYIPWKSQGSPGNCVILDPKGTWKHENCLSVKDGAICYKPTKFKELASHAHSSKCPLVKRNGSQWVQYGDHCYSAEQALHTFAEAKKLCQELDHSATVVTIADENENKFVSRLMRENYNITMRVWLGLSQHSLDQSWSWLDGLDVTFVKWENKSKNGDGKCSILIASNETWKKVECSRGYARVVCKVPLSPDYRGIAVLFAVLSVLALISGLIWFLVQRNHFRWTGLSSVRYEHGANEDEVMLPSFHD
What is the function of this protein?
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment.  Causes reduced proliferation of B lymphocytes (By similarity).
What are the official names of this protein?
Lymphocyte antigen 75, Ly-75, DEC-205.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein.
Protein: TRXB_TREPA
Sequence: METDYDVIIVGAGAAGLSAAQYACRANLRTLVIESKAHGGQALLIDSLENYPGYATPISGFEYAENMKKQAVAFGAQIAYEEVTTIGKRDSVFHITTGTGAYTAMSVILATGAEHRKMGIPGESEFLGRGVSYCATCDGPFFRNKHVVVIGGGDAACDESLVLSRLTDRVTMIHRRDTLRAQKAIAERTLKNPHIAVQWNTTLEAVRGETKVSSVLLKDVKTGETRELACDAVFFFIGMVPITGLLPDAEKDSTGYIVTDDEMRTSVEGIFAAGDVRAKSFRQVITATSDGALAAHAAASYIDTLQN
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGM_ASPFU
Sequence: MSVQTVSIQPFTDQKPGTSGLRKKVKVFQQPHYSEAFVTSILLSIPEGAEGAFLVIGGDGRYYNPEVIQKIAKISAAYGVKKLLIGQNGILSTPAASNLIRVRKATGGILLTASHNPGGPNADFGIKYNLCNGAPAPESVTNKIYETSKSLTSYKIAEIPDVDTSTIGTKTYGPLEVEIVHSTSDYLKMLKEIFDFDLIKEFLSTHKDFKVLFDGMHGVTGPYGVDIFVKELGLPQDSTMNCVPSPDFNGGHPDPNLVYAHELVEAVDKKGIHFGAASDGDGDRNMIYGANTFVSPGDSLAIIAHHAKLIPWFQKQGVYGLARSMPTSGAVDLVAKAQGLQSYEVPTGWKFFCNLFDNKKISICGEESFGTGSNHIREKDGVWAIVAWLNIIAGVAKQKPNETPSIASIQNEFWQTYGRTFFTRYDYENVDSDAANKLIANLSEKINNKDSFVGSTVSGRKVADAGNFAYTDLDGSVTKNQGLYVKFDDGSRLVVRLSGTGSSGATIRLYIEKYESDKSKFGMNTQDYLKDNVALAMSLLKFKEYIGREDPDVKT
What is the function of this protein?
Catalyzes the reversible interconversion of glucose 1-phosphate and glucose 6-phosphate.  Key enzyme in hexose metabolism.  The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.
What are the official names of this protein?
Phosphoglucomutase, PGM, Glucose phosphomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INO1_CANAL
Sequence: MSTPIEFKSSNSVTKDDHLYTKFTYENSVVEKDANGKFIVTPTASDYEFKVDLKVPKVGLLLVGIGGNNGTTLLGATLANKHNISFENKEGVVKPNYYGSVTQASTVKIGVDKETGEDVYVPFNSIVPMVNPNDLVVDGWDISGLPLDQAMKRAKVLDVTLQKQLYPYLENKKPLESIYYPDFIALNQSERANNVFNQVNGEVKTDNKWADVEKIRKDIRDFKAKNELDKVIILWTANTERYADVLPNVNDTADNLIKSIKESHEEIAPSTVFAVASILEKVPYINGSPQNTFVPGVIELAEKYDSFIGGDDFKSGQTKIKSVLAQFLVDAGIKPLSIASYNHLGNNDGYNLSSPKQFRSKEISKQSVVDDIIESNELLYNKESGDKVDHCIVIKYLPAVGDSKVAMDEYYSELMLGGHNKISIHNVCEDSLLATPLIIDLVVATEFATRVQVKGPGKSDYDELYPVASLLSYWLKAPLARPGFKPINGLNKQRQQLVNLLSVLVGLPIDNELRFERILK
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:18268031).  Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).
What are the official names of this protein?
Inositol-3-phosphate synthase, MIP synthase, Myo-inositol 1-phosphate synthase, IPS, MI-1-P synthase.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMP3_HUMAN
Sequence: MVRKLKFHEQKLLKQVDFLNWEVTDHNLHELRVLRRYRLQRREDYTRYNQLSRAVRELARRLRDLPERDQFRVRASAALLDKLYALGLVPTRGSLELCDFVTASSFCRRRLPTVLLKLRMAQHLQAAVAFVEQGHVRVGPDVVTDPAFLVTRSMEDFVTWVDSSKIKRHVLEYNEERDDFDLEA
What is the function of this protein?
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP).  Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
What are the official names of this protein?
U3 small nucleolar ribonucleoprotein protein IMP3, U3 snoRNP protein IMP3, BRMS2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DPO3A_CAUVN
Sequence: MSDAEGQGFVHLRVRSAYSLLEGAIKADQIGKLAAEAKMPAAGLADRANLFGALEYSSYAKDAGVQPIIGCAIPVVGIGGGPTERWARAPTLMLLAQNERGYLNLSELSSIAYLDSAELPEPVVPWAKVAEHSEGLILLSGGTDGPVDALFAAGKTAEASAALAEMHRVFGDRFYVELQRHGLPRQAAAEPGLVNWAYDHDVPLVATNDVYFAKPGFYDAHDALLCISDGAFVGQDERRRVTPEHWFKPAEEMRKLFADLPEACDNTLDIARRCAFMVHKRDPILPSFPTGDGRNEAEELEHQAREGLKMRLEGLTLSAPEEEYWKRLDFELGIIKKMGFPGYFLIVSDFIKWGKAHGIPVGPGRGSGAGSLVAWVLTITDLDPLRFGLLFERFLNPERVSMPDFDVDFCQERREEVISYVQEKYGRDRVAQIITFGSLQARAVLRDVGRVMQLPLGLVDRLCKMVPNNPAAPVTLAQAIDLEPRLKQAKKEDANVSACLDVALQLEGLFRNASTHAAGLVIGDRPLTQLTPLYKDPRSDLPATQFNMKWVESAGLVKFDFLGLKTLTVLDRAVKHLKKRGFEIDLGKLPFDDAKTYELLASGQTVGVFQLESQGMRDTLRKMRCGSIEEITALISLYRPGPMDNIDTFVDCKFGRKPVDTLHPSLEAVLKETYGVIVYQEQVMQIAQILAGYSLGEADLLRRAMGKKKKEEMDLQKIRFVSGAKEKNVPEEQSGSIFELVAKFAGYGFNKSHAAAYAFISYQTAWLKANTPVEFFAASMSLDLSNTDKLAVFHQDARRFGITVRAPDVNRSGADFEVENGEVLYALGAIRNVGLEAMKHLVAVRAEGGPFRDVFDFVERIDPRQVNKRAIENLARAGAFDSIHKNRAQIVASADVLIAHAQSCHADRQGGQGGLFGSDPGAGRPRLSKTENWNQVDLLDEELSAVGFYLTGHPLEDMVGMLRRRRTVMLAEAMAQAEAGAEAFRMCGVVRRRQERASQSGEKFAFVSLSDPTGEYEVLYPPESLRKCRDVLEPGKAVAIKVRAKARDGEVRFFGDDAEPIEKAVENVVAGLRVHLSPSAAEIDALKRRLEPAQAQKGGEVTFVAAIGGGREIELRLPGRYTLDAALRGALKTAPGVALLEDV
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase.
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_BURVG
Sequence: MASNNVAQFAAELKMPAGVLLEQLQAAGVQKASEDDALSETDKARLLDHLRKSHGATDGDKRKITLTRKHTSEIKQSDATGKARTIQVEVRKKRTFVKRDDVAEGAEQGQAQVAEADDDAELKRREEEARREAELLEQQAQELLERQERLEREEAERRAREEAAEAERRRAEEEAAAKRAAAEAAAAQQAAAQQAAEAKQEAPGAQSAQEEARAAAERAAQREAAKKAEDAAREAADKARAEQEEIRKRREAAEAEARAIREMMNTPRKAVVKAVEPPKPVEAPKPAEAKGTLHKPAKPAGAGVQARPAVKKPAGATPATTQAPAAGAGDRNKKPGGGKGGWQDDAAKRRGIKTRGDSSGGVDRGWRGGPKGRGRHQDSASTFQAPTEPIVREVHVPETISVADLAHKMSIKASEVIKVMMKMGQMVTINQVLDQETAMIVVEELGHRAVAAKLDDPEALLVEGETSSDAEQLPRPPVVTVMGHVDHGKTSLLDHIRRAKVAAGEAGGITQHIGAYHVETPRGVITFLDTPGHEAFTAMRARGAKATDIVVLVVAADDGVMPQTKEAIAHAKAGGVPIVVAINKIDKPEANPDRVKQELVAEGVVPEEYGGDSPFVPVSAKTGAGIDDLLENVLLQAEVLELKAPVEAPAKGIVIEAKLDKGKGPVATILVQSGTLNRGDIVLAGSAYGRVRAMLDENGKPTKEAGPSIPVEIQGLSEVPGAGEEVIVLPDERKAREIALFRQGKFRDVKLAKQQAAKLESMLEQMGEGEVQNLPLIIKADVQGSQEALVQSLLKLSTDEVRVQIVHSAVGGISENDVNLATASKAVIIGFNTRADAQARKLAEANGIDIRYYNIIYDAVDEVKAAMSGMLAPEKREVITGMVEVRQVFKVPKIGTVAGCMVTDGIVKRSSSVRVLRNNVVIFTGELESLKRFKDDVKEVKQGFECGMSVKNFNDIVEGDQFEVFEVTEVARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2B_VIPBB
Sequence: MRTLWIVAVWLMGVEGNLFQFGNMINHMVGKHAVWSYLSYGCYCGWGGQGKPQDATDRCCFVHDCCYGRANGCDPKLSTYSYNFQNGNIVCGNKYGCLRHICECDRVAAICFQKNMNTYNKKYKNYSSSNCQENSDKC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 Pla2Vb, VbbPLA2, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UBIG_BORPE
Sequence: MTTATQSSAPGVNVDQAEVEKFSALAARWWDPESEFKPLHAINPLRLGWIQETAGSLSGKRVLDMGCGGGILSESMAVAGAQVTGIDLAEKSLKIARLHGLESGVKVDYRAVPVEELAAEQPGQYDVVTCMEMLEHVPDPASVVRACAALAKPGGWVFFSTLNRNPKSFLFAIVGAEYVLRLLPRGTHSYDSFIKPSELATSARQAGLEPTGMRGMEYNPITQVYSLSANTSVNYLMSTRK
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: IL7_MOUSE
Sequence: MFHVSFRYIFGIPPLILVLLPVTSSECHIKDKEGKAYESVLMISIDELDKMTGTDSNCPNNEPNFFRKHVCDDTKEAAFLNRAARKLKQFLKMNISEEFNVHLLTVSQGTQTLVNCTSKEEKNVKEQKKNDACFLKRLLREIKTCWNKILKGSI
What is the function of this protein?
Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:7699333, PubMed:28811625).  Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG.  Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5.
What are the official names of this protein?
Interleukin-7, IL-7.
What is the protein family that this protein belongs to?
Belongs to the IL-7/IL-9 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYR1_EMENI
Sequence: MPETVGHEEPALPSSPQAGGAVAYNAISKELQPLPPTETANGGIIPPASSRIEGSTGRLCALELEDGTVYQGYNFGAEKSVAGELVFQTGMVGYPESITDPSYRGQILVITFPLVGNYGVPSRETMDELLKTLPKHFESTEIHIAALVVATYAGENYSHFLAESSLGQWLKEQGVPAIHGVDTRALTKRIRQKGSMLGRLLLHKADVAETDAALAQDTWKSSFEQIDWVDPNTKNLVSEVSIREPKLFSPPENVALKHPSSRPIRVLCLDVGLKFNQLRCLVARGVEVLVVPWDYDFPTLAGKDYDGLFVSNGPGDPATMTTTVNNLAKTMQEARTPIFGICLGHQLIARSVGAQTLKMKFGNRGHNIPCTSLVTGKCHITSQNHGYAVDSSTLPSDWQELFVNANDGSNEGIRHVSRPYFSVQFHPESTPGPRDTEYLFDVFINAIKDTIASPEALQKPVNFPGGAVAENIKASPRVSVKKVLILGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFLPVNADFVRKVIKHERPDAIYVTFGGQTALQVGIQLKDEFESLGVKVLGTPIDTIITTEDRELFARSMDSIGEKCAKSASASSLEEALQVVESIGFPVIVRAAYALGGLGSGFADNLDELKDLCAKAFAASPQVLIERSMKGWKEIEYEVVRDARDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPYSKEYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLNIPLNEIKNSVTKVTCACFEPSLDYCVVKIPRWDLKKFTRVSTQLGSSMKSVGEVMAIGRTFEEAIQKAIRSVDFHNLGFNETNALMSIKTELQTPSDQRLFAIANAMAAGYSVDDIWKLTNIDKWFLTRLKGLSDFGKLMTNYNASTVTAPLLRQAKQLGFSDRQLAKFLSSNELAIRRLRVEAGIIPIVKQIDTVAAEFPSVTNYLYLTYNASEHDVRFDDNGIMVLGSGVYRIGSSVEFDWCSVRTIRTLREQGHKTVMVNYNPETVSTDYDEADRLYFENINLETVLDIYQLESSSGVIMSMGGQTPNNIALPLHRLNVRILGTSPEMIDGAENRYKFSRMLDRIGVDQPAWKELTSIEEAREFCDKVGYPVLVRPSYVLSGAAMNTVYSEHDLASYLNQAADVSREHPVVITKYIENAKEIEMDAVARNGVMVGHFISEHVENAGVHSGDATLILPPQDLDPETVRRIEEATRKIGNALNVTGPFNIQFIAKDNDIKVIECNVRASRSFPFVSKVMGVDLIEMATKAMIGAPFAEYPPVTIPKDYVGVKVPQFSFSRLAGADPVLGVEMASTGEVASFGRDKYEAYLKALLSTGFKLPKRNILLSIGSYKEKMEMLPSIIKLRDVGFELFATSGTADFLKENGVPVKYLEILPGEDEDIKSEYSLTQHLANNLIDLYINLPSSNRFRRPANYMSKGYRTRRMAVDYQTPLVTNVKNAKILIEAIARHYALNVQTIDYQTSHRSIILPGLINVGAFVPGLGSADSKDFEAVTKASIAAGFSMIRVMPVGVDSSITDARTLKLVQQNAGKASFCDYNFSVVATSSNSAEVGQLTGEVGSLFIPFNHLSGNISKVAAVTSHFGAWPSSKPIITDAKSTDLASVLLLASLHSRNIHVMSVTSKEDIGLIALSKEKGLKVTCDVSIYCLFLSRDDYPEAAFLPTAEDQKALWEHLSTIDIFSIGSIPYQLAGEKGSPAAGIAEALPLLFTAVSEGRLTVEDIIARLYENPKKIFELHDQSDSSVEVEIDRPYLFQSAQAWSPFSGKSVKGLVQRVIFQGKTSCLDSEITPDAPKGSDMSGHRIVPASPSLKAMSPRVDGALDRRQSISIAGTPARLGRKPVDHFPAATGAELGPPLYTPVPRASSPLLQMLSRSPFKQKHVLSVNQFNRADLHLLFTVAQEMRLGVQREGVLDILKGRLLCTLFYEPSTRTSASFDAAMQRLGGRTIAISTEHSSTKKGETLQDTLRTLGCYGDAVVLRHPEPSSTEVAAKFSPVPVINGGNGSVEHPTQAFLDLFTIREELGTVGGLTITFTGDLKYGRPVHSLIKLLQFYDVRVQLVAPKDLSLPADIRQQLLATGQLLTESEELTPEIVARSDVLYSTRVQKERFADLEQYERLKNSFIIDNALLKHAKSHMVVMHPLPRNAEVSEEVDFDQRAAYFRQVSLQSRGPSSEFDMLMWMQMRYGLYCRMALLALIMAP
What is the function of this protein?
This protein is a 'fusion' protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase).
What are the official names of this protein?
Protein pyrABCN.
What is the protein family that this protein belongs to?
In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
Protein: NU6M_AETPU
Sequence: MTYFVLFLGLCFVLGGLAVASKPSPYYGVVGLVLASVAGCGWLLSLGVSFVSLVLFMVYLGGMLVVFVYSVSLAADPFPEAWGDLGVVGYGVGFVMVLMVGMVVGGFVGSLDFGVVTVDSVGMFSVRLDFSGVAMFYSCGVGMFLVAGWGLLLTLFVVLELVRGLSRGAIRAV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: HSCB_VIBPA
Sequence: MNHFELFGLPSQFQLDGSLLSSKFRELQKRFHPDNFATASERDRLMSVQKAAQINDAYQVLKHPISRAEYILAEQGMEIRGEQQTMQDPMFLMEQMELREELEDIADCSDPESALFDFDSKVSKMYKQHLASVEQELNDGLWAEAADRVRKLKFIAKLKNEIELVEDKLLG
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.