PharMolix/UniProtQA huggingface dataset:
Protein: TRMN6_SALAR
Sequence: MSHSGSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVADVKRILDIGTGSGLLALMLAQRTDDNVPVDAVELDAEAAMQAQENVAHSPWAHRITVHTDDIQRWAPRQTVRFDLIISNPPYYEPGVECATPQREQARYTATLDHQTLLAIAADCITEDGFLCVVLPEQIGNAFTQQALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQHYSESYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_ESCF3
Sequence: MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDSQSDQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVELTKRYYEQDDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVKNVLGLTLPQTLEQYDIVVTQDDAVKNMFRAGPAGIRTTQAFSQDCRWDTLDDDRSNGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGSIGLIEDGDLIAIDIPNRGIQLQVSDAELAARREAQEARGDKAWTPKNRERQVSFALRAYASLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: IF5_YEAST
Sequence: MSINICRDNHDPFYRYKMPPIQAKVEGRGNGIKTAVLNVADISHALNRPAPYIVKYFGFELGAQTSISVDKDRYLVNGVHEPAKLQDVLDGFINKFVLCGSCKNPETEIIITKDNDLVRDCKACGKRTPMDLRHKLSSFILKNPPDSVSGSKKKKKAATASANVRGGGLSISDIAQGKSQNAPSDGTGSSTPQHHDEDEDELSRQIKAAASTLEDIEVKDDEWAVDMSEEAIRARAKELEVNSELTQLDEYGEWILEQAGEDKENLPSDVELYKKAAELDVLNDPKIGCVLAQCLFDEDIVNEIAEHNAFFTKILVTPEYEKNFMGGIERFLGLEHKDLIPLLPKILVQLYNNDIISEEEIMRFGTKSSKKFVPKEVSKKVRRAAKPFITWLETAESDDDEEDDE
What is the function of this protein?
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S. mRNA. Met-tRNA[F]. eIF-2. GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide.  The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S. mRNA. Met-tRNA[F]).  eIF-5 is essential for cell viability.
What are the official names of this protein?
Eukaryotic translation initiation factor 5, eIF-5.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: Y5597_ARATH
Sequence: MGGEKFGFLIWILSIPCLIFLCYGYVPVDNYLINCGSSTNVTVTSRVFISDNLASNFLTSPNEILAASNRNSNSDIYQTARIFTGISKYRFSVARGRHWIRLHFNPFQYQNFQMVSAKFSVSSETHVLLSDFTVSSRVMKEYSLNVATDHLELTFTPSGDSFAFLNALEVVSVPDTLFSGDPSFAGSPGKFQGLSWQALETVYRVNMGGPRVTPSNDTLSRIWEPDSEFLVEKNLVKSVSKIASVDYVPGFATEETAPRTVYGTCTEMNSADNPSSNFNVTWDFDVDPGFQYFLRFHFCDIVSKALNQLYFNLYVDSMDVVENLDLSSYLSNTLSGAYAMDFVTGSAKLTKRIRVSIGRSSVHTDYPTAILNGLEIMKMNNSKSQLSIGTFLPSGSSSTTKKNVGMIIGLTIGSLLALVVLGGFFVLYKKRGRDQDGNSKTWIPLSSNGTTSSSNGTTLASIASNSSYRIPLVAVKEATNSFDENRAIGVGGFGKVYKGELHDGTKVAVKRANPKSQQGLAEFRTEIEMLSQFRHRHLVSLIGYCDENNEMILVYEYMENGTLKSHLYGSGLLSLSWKQRLEICIGSARGLHYLHTGDAKPVIHRDVKSANILLDENLMAKVADFGLSKTGPEIDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVMFEVLCARPVIDPTLTREMVNLAEWAMKWQKKGQLEHIIDPSLRGKIRPDSLRKFGETGEKCLADYGVDRPSMGDVLWNLEYALQLQEAVVDGDPEDSTNMIGELPLRFNDYNHGDTSVNFSVAKEGRFDEEESSVDDSSGVSMSKVFSQLIKSEGR
What are the official names of this protein?
Probable receptor-like protein kinase At5g59700.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: Y1968_CLOP1
Sequence: MENRFEISMLIDYYGTLLTEKQFNVMTLYYNEDLSLAEIAEINKTSRQAIYDLIKRCCKQLHSYDEKLKLSKKIDKRYRIKEELMAELNKNSNLDEDIKKYIDEKLEEIINA
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein CPF_1968.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: PAL_ECOLI
Sequence: MQLNKVLKGLMIALPVMAIAACSSNKNASNDGSEGMLGAGTGMDANGGNGNMSSEEQARLQMQQLQQNNIVYFDLDKYDIRSDFAQMLDAHANFLRSNPSYKVTVEGHADERGTPEYNISLGERRANAVKMYLQGKGVSADQISIVSYGKEKPAVLGHDEAAYSKNRRAVLVY
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity (PubMed:11115123, PubMed:17233825).  The Tol-Pal system is also required for polar localization of chemoreceptors clusters (PubMed:24720726).  The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity (PubMed:32152098).
What are the official names of this protein?
Peptidoglycan-associated lipoprotein, PAL, Tol-Pal system lipoprotein Pal.
What is the protein family that this protein belongs to?
Belongs to the Pal lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity.
Protein: NUOA_PELUB
Sequence: MLSEFLKDYLPIIIFLIIALGLSCAFVVVNLILSPKHPDPEKLSAYECGFEPFEDSRMEFDVRFYLVAILFIIFDLEIAFLFPWAISLGNIGGLGFTSMMIFLFILTVGFIYEWKKGALDWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILVC_CAUSK
Sequence: MRVYYDRDADLARILDKKIAIVGYGSQGHAHALNLRDSGATNVAVALRAGSPTAKKAQGEGLKVMTVAEAAAWADLLMILAPDEHQAAIYKNDIAPNIRDGAALLFAHGLNVHFGLIEPKDTIDVLMVAPKGPGHTVRGEYQKGGGVPCLIAVHHNATGNALDLGLAYASAIGGGRSGIIETNFREECETDLFGEQAVLCGGTVDLIRCGFEVLVEAGYAPEMAYFECLHELKLIVDLIYEGGIANMNYSISNTAEYGEYVTGPRIVTAETKAEMKRVLEDIQSGKFVRDFMLENAVGQPSFKATRRRASEHQIEEVGARLRGMMPWIAKNKLVDVTKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SURE_CAMLR
Sequence: MKRILLTNDDGYESKGLIKLAKMLKKHFKAEITIVAPANEKSACSHSITLTKPLRFQKVKKRFYKLEDGTPADCVYLALHALYKNHLPDLIISGINKGANVGEDITYSGTCAGAMEAVLHGIPAIALSQFYQDDQKELNFKLALNITKKIVKKVFKKGFPLDKKEFLNINFPSSKTNFKGIKICKAGKRIYSYEAHSNINPRGIEYYWLAAANLDHEDEKKSDITLLKQGYATITPIMLNLTAYKQMKNLKKWMKNG
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECH12_MYCLE
Sequence: MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLMKSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVEGLTQPVRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVASTRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAASLDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG
What is the function of this protein?
Could possibly oxidize fatty acids using specific components.
What are the official names of this protein?
Probable enoyl-CoA hydratase echA12.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: METK2_RHOPB
Sequence: MRASYLFTSESVSEGHPDKVCDRISDEIVDLFFREGPKAGIDPWAIRAACETLATTNKVVIAGETRGPASVTNEHIEHVVREAIKDIGYEQDGFHWKTADIEILLHPQSADIAQGVDALQPGTNQEEGAGDQGIMFGYATNETPDLMPAPIFYAHKILRLISEARHSGKEKVLGPDSKSQVTIQYENGKPVGVREIVVSHQHLVEDMTSNQVRERVEPYVREALPEGWITDKTIWHINPTGKFFIGGPDGDTGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYASRYLAKNIVAAGLADRCTLQLAYAIGVARPLSIYIDTHGTGKVTEDKLEKAVAEAMDLTPRGIRKHLDLNKPIYARTSSYGHFGRTPDAEGGFSWEKTDLAEALKRAI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase 2, AdoMet synthase 2, MAT 2, Methionine adenosyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_AFIC5
Sequence: MSASGRSAREKLNFQLGLRRRGISDQAVLRALEDVPREQFVEPHDKEVAYADTALGIACGQTISQPYVVAYMTEQLRTHPRHRALEIGTGSGYQAAVLSRLCRQVVTVERYRTLADTARARLAALGCRNVEVVVGDGYDVPDTLGTFDRIIVTAAMETIPDSLMERLEPDGIMLVPVGPPEGVQQLVRLRKGADGVEQEDLIPVRFVPALVGLAKEL
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2CX_CITFR
Sequence: MDIISKSGEGNKYTINSAIAFVAYASHIDINTTEFSKVLSGLRDFINDEAIRLGGKISDGSFNKCNGDWYEWLIGIRAIEFFLESETNFIVVKMPNATSFDVMSIYKSCLSEFIYDLRSKLSLNNVNLITSNPDFSIIDIRGRREELKSMLKDISFSNISLSTISEIDNLYKNFIDYAELEHIKSFLSVKTTFRPDRRLQLAHEGSLMKALYTHLQTRTWTINPTGIRYYAAATSIGNADVIGLKTVATHSITDVKSLPQSAVDEIFKINSVLDVDSCLSHILSS
What is the function of this protein?
An F and P subtype restriction enzyme that recognizes the double-stranded sequence 5'-RCCGGY-3' and cleaves after R-1.
What are the official names of this protein?
Type II restriction enzyme Cfr10I, R.Cfr10I, Endonuclease Cfr10I, Type-2 restriction enzyme Cfr10I.
Protein: DLLB_DANRE
Sequence: MAHLSLYCLLSVSLLQLVASSGVFELKVHSFSTTRRFCRRTRDCNIFFRICLKHSEDVISAEPPCTFGTGQTSVLRADQSSIASSAAIRVPFHFKWPGTFSLIIEAWNAESPKEHHDYTENQNNLISRLATRRRLAVGEDWSQDVHFGDQSELRYSYHVFCDEFYFGEACSDYCRPRDDTLGHYTCDENGNKECLVGWQGDYCSDPICSSDCSERHGYCESPGECKCRLGWQGPSCSECVHYPGCLHGTCSQPWQCVCKEGWGGLFCNQDLNYCTNHKPCANGATCTNTGQGSYTCTCRPGFGGTNCELEINECDCNPCKNGGSCNDLENDYSCTCPQGFYGKNCEIIAMTCADDPCFNGGTCEEKFTGGYVCRCPPTFTGSNCEKRLDRCSHKPCANGGECVDLGASALCRCRPGFSGSRCETNIDDCARYPCQNAGTCQDGINDYTCTCTLGFTGKNCSLRADACLTNPCLHGGTCFTHFSGPVCQCVPGFMGSTCEFPVQASLEKMAPRVGQTSPSAVAVSCVLGVLAVFLGVCVGLVVLRRRRHRLRRQQLCDSVFNDLETVNNLDRQHYPYDRDFSQVKPCNTEGRISLAASHTLPAGQEFLWSAGGGLR
What is the function of this protein?
Acts as a ligand for Notch receptors and is involved in primary neurogenesis.  Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation.
What are the official names of this protein?
Delta-like protein B, DeltaB.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TSR3_HALSA
Sequence: MELHVRYEGDDDPEKCTARKLARFDLAALHRTGRETPAGVVLNPHAERALSPADDTDMLVALDCSWETAGRAMFEIDGEHRALPFLVAANPVNYGQPFQLNTVEAFAGALAILGRWERAEELLSKFTWGHTFLELNEEPLRRYADCEDSSEVVAVQQAYLDAGED
What is the function of this protein?
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M. jannaschii 16S rRNA.  It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
What are the official names of this protein?
16S rRNA aminocarboxypropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. TSR3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC_CRIFA
Sequence: MPPKARAPLPPGDAARGEKLFKGRAAQCHTANQGGANGVGPNLYGLVGRHSGTIEGYAYSKANAESGVVWTPDVLDVYLENPKKFMPGTKMSFAGMKKPQERADVIAYLETLKG
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c, Cytochrome c555.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: RL35_LEUMM
Sequence: MPKMKTHRASAKRFKKTANGGLKSASAYTSHRFHGKTKKQRRQLRGTRMMDSTTVKTYAKMLSTL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: LECT2_CAEEL
Sequence: MHLRTLHFLILIGIFIGGQTLGCMKKVCGNNAKNDFRRCPDTDGSCGNYHTERTSGEIIDGVDVRCHLGEPIYAPIEGEMYFWRPYGGKREKSCADQGVRIEGTGQWQGYAVHISSVKLSFFGGHVEAGDEIGEALNRYCFNDRGQNDVEPHVEIRLYKEGRLIDPTHHLQNCMCTGQICESNTRNVLLGDPFKTDKRYNGVRGWDVECQMIDDDDEDSPRAPMIYSPIAGEIVGRIRLFTDSNGAYTGCDNDGIFIVGIDDWLGFEARLYNVKARADIGFGRKRIIQGEPIATRLACENSPDSVFVEIRFEGRVVNITDIITAANCKTPNFPVF
What is the function of this protein?
Muscle-derived dendritic guidance cue, which is required for the formation of somatosensory dendritic arbors which extend from PVD and FLP sensory neurons during development (PubMed:27451901).  Ligand of a multi-protein dma-1 receptor-ligand complex, which is activated upon binding of lect-2, mnr-1 and sax-7 ligands to control the growth of dendrites that extend anteriorly from the PVD neuronal cell body (PubMed:27451901, PubMed:27705746).  Enhances the binding of the mnr-1 and sax-7 ligands to the dma-1 receptor-ligand complex (PubMed:27705746).  Restricts the growth of secondary PVD dendritic branches and any irregularly positioned ectopic tertiary dendritic branches that originate from secondary branches, and promotes the formation of stable higher order dendritic branches (PubMed:27451901, PubMed:27705746).  In particular, it is required for the formation of quaternary PVD dendritic branches and promotes their innervation of body wall muscles (PubMed:27705746).  Promotes self-avoidance of tertiary dendritic branches of PVD sensory neurons (PubMed:27451901).  Not required for the growth of dendrites that extend from AIY and PVQ interneurons, DVB GABergic neurons, PLM and ALM mechanosensory neurons, AFD sensory neurons and DD/VD and DA/DB motor neurons (PubMed:27451901).
What are the official names of this protein?
Leukocyte cell-derived chemotaxin-2 homolog, Chondromodulin II.
What is the protein family that this protein belongs to?
Belongs to the LECT2/MIM-1 family.
What are the subcellular locations of this protein?
Secreted. Cell junction. Secreted, extracellular space, extracellular matrix, basement membrane. Cell projection, dendrite. Perikaryon. Cell surface. Note=Secreted by body wall muscles and taken up by coelomocytes (PubMed:27451901, PubMed:27705746). Localizes to the basement membrane of hypodermal tissues, body wall muscles and along fibrous organelles in larvae and adults (PubMed:27451901). Co-localizes with sax-7 at dendrites (PubMed:27451901, PubMed:27705746). Dendritic localization is dependent on sax-7, but not mnr-1 or dma-1 (PubMed:27451901, PubMed:27705746).
Protein: WHIA_GEOTN
Sequence: MSFASETKKELTNLEVKHCCLRAELSALLRMNGSLSFSGGRMTVDVQTENAAIARRIYMLLRKGYDVAVELFVRKKMRLKKNNVYIVRITDGAASLLRELYIWNGDFSFVHDISPELIKKKCCKRSYLRGAFLAGGSVNNPETSSYHLEIFSLYEEHNRSLCELMNSHFFLNAKTLERKKGFITYLKEAEKIAEFLNIIGAHQALLRFEDIRIVRDMRNSVNRLVNCETANLNKTIGAALRQVENIRYIDETIGLDSLPAKLREIAKLRIEHQDVTLKELGEMVAGGKISKSGINHRLRKIDEIAERLRAGKPVDFHKSL
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: EIF3D_PHANO
Sequence: MAPASLLDLVSALPATESWGPAVSDETMLDGVPFAPYSKGDKLGRMADWTEGKDRERGGRQQYGNRNYRDQQVYGANQQTNPFAIQAAEEEATFSVVDNTRTSTRTRGFGRGGGTVFGRGRGQRGGQAQRGGRGTFQRVGGRGGQQYDSRGGRGGGRGGRRFGWRDDKPQRNRDASVQVKPEWTVMEEIDFSRLGKLNLDTGDGEDLENYGFLYYYDRSYDKQPGAKTSERRLNVLERAAYNVTTSSDPILQELSDKDEATVFATDNVLSMLMCATKSVYSWDLVFSRKGNKVFIDKRDGSNLDMVTVNENAADAPLEISEGNKDSINSPGALMLEATHINNVFPLQVVSESDTNKVNMTHEHPFYNEEVETDPPASKAYRYRRFDLSLEKDDEPLHLIVRTELDAVVKNNINGEDQYLTIKALNEFDNKAQGSGGALDWRSKLASQRGAVLATEMKNNSCKLARWAVQSILAKADTMKLGFVSRTNPKNNNDHVILGVLTNKPRDFASQMALNLNNGWGIVRTIVDMVLRMDEGKYVLVKDPNKSLLRLYQVPLHTFEEEDVEDMQAPNEEDEE
What is the function of this protein?
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit D, eIF3d.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBDZ_ECOLI
Sequence: MAFSNPFDDPQGAFYILRNAQGQFSLWPQQCVLPAGWDIVCQPQSQASCQQWLEAHWRTLTPTNFTQLQEAQ
What is the function of this protein?
Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine.  Plays a role in the catalytic function of EntF.  It is required for adenylation of amino acids in non-ribosomal peptide biosynthesis.
What are the official names of this protein?
Enterobactin biosynthesis protein YbdZ.
What is the protein family that this protein belongs to?
Belongs to the MbtH-like family.
Protein: AKT2_HUMAN
Sequence: MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
What is the function of this protein?
One of the few specific substrates of AKT2 identified recently is PITX2.  Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1.  AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake.  Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes.  AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2.  Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.  Phosphorylates CLK2 on 'Thr-343'.
What are the official names of this protein?
RAC-beta serine/threonine-protein kinase, Protein kinase Akt-2, Protein kinase B beta, PKB beta, RAC-PK-beta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (By similarity).
Protein: T4149_TANPA
Sequence: MANILSLETLLISWLSSFILMFFILKWVSFYSKTKKNLPPSPQKLPIIGNFHQLGPNPHRSLQALSEKHGPIMLLHLGSVPMLVASNSEVAQEIMKTHDVSFASRPNSPILNILLYGCKDIAFAPSGEYWRQLKSIIVSNLLSSTQVKSFKNVREKEIGHMIGVIGESYGSSVDMSALLVSLAENVICTVALGRKFDGLKLTSLLRRYLSMFNLFSVGSYIPWLSWVDQLSGLTGRATKVVKEFDEFLEVIIEDHANAKINGGKDFIDMLLNAQQDQTTGFAFQRDTIKAVIFDIFGGGIDSVSTSIDWVMSELVKHPNVMKKLQKEVTEISQGRSMVAEEDLEKMQYLKAVIKESWRLHPPVPLLIPRKSTNDVKLMGYDIQAGTQVMVNVWQIGRDPTLWDEPNEFRPERFSKGSVNYSGLNFEWLPFGVGRRACPGTQFGAAVIELAIANIVYKFDLALPNGVKHEDLDMSEKYGITVHRKNPLLVTASPRF
What is the function of this protein?
Probably involved in the biosynthesis of germacrene-derived sesquiterpene lactones.
What are the official names of this protein?
Cytochrome P450 Tp4149, Tp4149.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RNC_ESCF3
Sequence: MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSYVIANALYHRFPRVDEGDMSRMRATLVRGNTLAELAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQTVEKLILNWYQTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPTYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.