PharMolix/UniProtQA huggingface dataset:
Protein: BPT_COLP3
Sequence: MSDTSYKLGITKTFPCNYLPDQQERLLIAVDERLHNSESYGWLMTQGFRRSGDQSYRPSCPNCNACQSIRVLTSDFLPSKSQKRSKKRNSHFIIKQSSQLKDSYYPLFENYINTLHQDGSMYPASFQQFESFLSCNLTQQLFIETWAPANEENGPKEDKLVCVAVTDVLSNGLSAVYTFYHPDYKANGLGVFSILTQLSLSQQMSLPYLYLGYQIDECQKMNYKDRYFPFERFIDGQWLINTKPSVNKAKIAK
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK33_NASOF
Sequence: MAKGKDVRVTIILECTSCVRNDIKKESSGISRYITQKNRHNTPSRLELRKFCPYCYKHTIHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS6E_METMP
Sequence: MAFKVVVSDSKTGKSYQFETESNALIGKKIGDEISGSIVELEGYKLKITGGSDRCGFAMRHDIHGAMKMRVLLKEGPGYNVKEKGLRRRKSLRGNTISKDITLINTKVVEYGSAPLGGEPESTE
What are the official names of this protein?
30S ribosomal protein S6e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: FM98_ECOLX
Sequence: MRMKKSALTLAVLSSLFSGYSLAAPAENNTSQANLDFTGKVTASLCQVDTSNLSQTIDLGELSTSALKATGKGPAKSFAVNLINCDTTLNSIKYTIAGNNNTGSDTKYLVPASNDTSASGVGVYIQDNNAQAVEIGTEKTVPVVSNGGLALSDQSIPLQAYIGTTTGNPDTNGGVTAGTVTASAVMTIRSAGTP
What are the official names of this protein?
Fimbrial protein 987P, Fimbrial adhesin 987P.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: ZIPA_ECOK1
Sequence: MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDEDVEDDEGVGEVRVHRVNHAPANAQEHEAARPSPQHQYQPPYASAQPRQPVQQPPEAQVPPQHAPRPAQPVQQPVQQPAYQPQPEQPLQQPVSPQVASAPQPVHSAPQPAQQAFQPAEPVAAPQPEPVAEPAPVMDKPKRKEAVIIMNVAAHHGSELNGELLLNSIQQAGFIFGDMNIYHRHLSPDGSGPALFSLANMVKPGTFDPEMKDFTTPGVTIFMQVPSYGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDIIREVKDANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: C513E_DICDI
Sequence: MNLYISILILIISLIIFFKNNNRISKINSKIPGPIRLPIFGNLLQINKDPHIQFQKWYEKYGVIYSIRLGNIETVVFTGYPIFKKAFIENSQIFAPRFQHLSRFEANGCKNLIGSNDEIHSTLKKLILTEITSNKIKKMENHIVLECENLCKQLDKHCQDGLPFSLNMYFKLFSLNIILRFLFGTINNSYQDKSNQDIVDVIIEFLHYGGNPIMSDFIPILKPFYKQNKFFKFYPILCDHLNKLIENYKNNKQLQKQQKQQQNEDDDDDDDGTIIGKLLKEYHNGKISWTSVVSTCVDVFLAGVDSTSNSTIFTLIALVNNSNCQEKLFNEIKNNLKKSDDGHDEIVIRHSLYRSSIPYLSLVMKEVYRLYSVILIGLPHITSEDVEIEGYKIAKGTQIIQNVFSTHLCEKTFPMSKSFIPERFIETGSNNMFGGGQTNLVHFGTGVRDCVGKSLADCEIFTVLATLINRYQFINPTLEPLNDIGSFGIAYQPPINNFIIKKRL
What are the official names of this protein?
Probable cytochrome P450 513E1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RNH2_PARD8
Sequence: MLLPYMETGRIEAGCDEAGRGCLAGAVFAAAVILPEDFKNEDLNDSKQLSEKKRYKLRPVIEREAIAWAVGIVSPEEIDKINILKASFLAMHRAIEQLKVRPEHLLIDGNRFTPYPDIPHTTVVKGDGKYLSIAAASILAKTYRDDYMNELALEYPAYHWLDNKGYPTKVHREAIRTHGITPYHRKTFTLLPEQLTLGF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COP3_CONPU
Sequence: MKLLAPVLWAMAALGVTWLVAVDSKESCTKHSNGCSTPLRLPCQEYFRPACDIHDNCYHCGKTFGISREECDKAFLKDMNTLCKKLGSNSATCPARGKREVTSHRATSIAHSRLWKTALDQKSFLNRKARQVFFLLPTTCQGWAKNYHLAVKLAGANSYSVTTDLETCQGLEHCLPNH
What is the function of this protein?
Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Conodipine-P3, Cdpi-P3, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2, PLA2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group IX subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LEUD_RHOPS
Sequence: MDKFTTLEGVAAPLKIINVDTDMIIPKQYLKTIKRTGLGKGLFSEQRYNDDGSENPDFILNKPAYRNAKILVAGDNFGCGSSREHAPWALLDFGIRCVISTSFGDIFYNNCFKNGVLPIRVSQADLDKLFDDAERGSNATVTIDLPAQEIRGPDGGTVKFEIDPFRKHCLINGLDDIGLTLEKKASIDSYEDKAKTERAWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: EASG_ASPFU
Sequence: MTILVLGGRGKTASRLSLLLDNAGVPFLVGSSSTSYVGPYKMTHFDWLNEDTWTNVFLRASLDGIDPISAVYLVGGHAPELVDPGIRFINVARAQGVNRFVLLSASNIAKGTHSMGILHAHLDSLEDVQYVVLRPTWFMENLLEDPHVSWIKKEDKIYSATGDGKIPFISADDIARVAFSVLTEWKSQRAQEYFVLGPELLSYDQVADILTTVLGRKITHVSLAEADLARLLRDDVGLPPDFAAMLASMETDVKHGTEVRNSHDVKKVTGSLPCSFLDFAEQEKARWMRH
What is the function of this protein?
Festuclavine dehydrogenase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid (PubMed:15933009, PubMed:22453123).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:15870460).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:20039019, PubMed:20526482, PubMed:21409592).  EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:20526482).  EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:20526482).  Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A (PubMed:26972831).  Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus (PubMed:19672909).
What are the official names of this protein?
Festuclavine dehydrogenase easG, Ergot alkaloid biosynthetic protein G.
What is the protein family that this protein belongs to?
Belongs to the fgaFS/easG family.
Protein: RS5_BURP1
Sequence: MAKMQAKVQADERDDGLREKMISVNRVTKVVKGGRILGFAALTVVGDGDGRVGMGKGKAKEVPVAVQKAMEQARRNMFKVPLKNGTLQHEVHGKHGASTVLLAPAKDGTGVIAGGPMRAVFDVMGVQNVVAKSHGSTNPYNLVRATLDGLRKQSTPADIAAKRGKSVEEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: OBAS1_HUMAN
Sequence: MYTASSSAETLRTVRRRSVPSSSMPYLALAHNRVSSLNHAASVDGWGTSHRNVADSFSRTSRSCSRFLKGTAGSARREDWNGHLQPWIPRPDRRGWETADRKGERTQVHGLRRSLGPRAPHPGAHRALRPAQSCRSGPRGWTPCRCRGRGPTACRRGS
What are the official names of this protein?
Putative uncharacterized protein OBSCN-AS1, OBSCN antisense RNA 1, OBSCN antisense gene protein 1.
Protein: AIMR_BPPHT
Sequence: MIKNECEKDNQLAARLAKLAGYEKVNGFYKFVNTPEKEMENLGGLLKIVKNLFPDSEEQLLSEYFLELDPNKKCARQSVEYSDINQWDTLTDKIIINLCNSKNSTSQEWGKVYSLHRKLNKNEISLNDAIRESGKCKIKSAEMLFFSNAMLMYAYLNIGEFGLMKSTSKLLEFDDLPEGFIKESFKSRVSMLEANISLNENSLLEARQHSNRAIENSNVNRICFFAYLTIGNTLIFEDYDEAKKAYIKGQKYAKNPVHQEMLDGALCFLSNIWKKENQWVNYNSDNIKYLQLRAFYYINQGNIEEATEILDELSSRDQDENELGFYYYYKGLISQDKTDYYKSIRYFKKSDDKYFIQLPLLQLERMGADLELLNLISI
What is the function of this protein?
Transcriptional regulator which is part of the latency-replication switch system that decides at the onset of infection whether to replicate and lyse the host or to lysogenize (latency) and keep the host viable.  Activates the transcription of the aimX locus.  Transcriptional activation of aimX seems to lead to the productive viral replication (lytic cycle), aimX possibly acting as a regulatory non-coding RNA.
What are the official names of this protein?
AimR transcriptional regulator, Arbitrium communication peptide receptor.
Protein: ATP8_BALMU
Sequence: MPQLDTSTWLLTILSMLLTLFVLFQLKISKHSYSPNPKLVPTKTQKQQTPWNITWTKIYLPLL
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: BIOC_GEOSL
Sequence: MIDRRKVRNAFHRGAADYDAYAAVQKRVMERILSLLFAEGVEPARILDVGAGTGALALRLADRYPSAAITCVDLAHGMARQARDNLGRTMERLVAVADAEHLPLRDGVFDLVVSTSTFQWLTTLDRAFAEARRVLADDGLFAFALFGDGTFKELKASYRAALHSVPRGGRDRTHRFFTRDEVRAALARAGFRSVEVFDEDEVEYHPDVPAFLRSVKRIGAGNASPVAGRGLSGRRVMETMMRTYAERFGGADGIPATYTVVYGVGKR
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase, Malonyl-ACP O-methyltransferase, Biotin synthesis protein BioC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: OTSA_MYCA1
Sequence: MAPGGGRGSKTASYGNSDFVVVANRLPVDQERLPDGSTAWKRSPGGLVTALEPLLRRQRGAWVGWPGIVDEDVDHEDDPIVQDDLELRPVKLSADDVAEYYEGFSNATLWPLYHDVIVKPIYHREWWDRYVAVNRRFAEATSRAAARGATVWVQDYQLQLVPAMLRELRPDLTIGFFLHIPFPPVELFMQLPWRTEIVKGLLGADLVGFHLTGGAQNFLFLSRRLIGANTSRGAVGVRSRYGEVELESRVVRVGAFPISIDSTALDQTARHRDIRRRAREIRAELGNPRKVLLGVDRLDYTKGIDVRLKAFSELLAEGRAKRDDTVLVQLATPSRERVDSYQQLRNDIERQVGHINGEYGEVGHPVVHYLHRPVPRNELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLVNPHDLEGVKDTVEAALNQSVEEGRRRMRSLRRQVLAHDVDRWARSFLDALAESGPRDG
What is the function of this protein?
Probably involved in the osmoprotection via the biosynthesis of trehalose and in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P).  Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate.  Probably also able to use ADP-Glc, CDP-Glc, GDP-Glc and TDP-Glc as glucosyl donors.
What are the official names of this protein?
Trehalose-6-phosphate synthase, TPS, Alpha,alpha-trehalose-phosphate synthase [UDP-forming], Osmoregulatory trehalose synthesis protein A, OtsA.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 20 family.
Protein: T263A_XENLA
Sequence: MSQTEKIEEPVPSYLCEEPPEGTVKDHPQQQPGMISRVTGGIFSMTKGAVGATIGGVAWIGGKSFEVTKTAVTSVPSIGVGIVKGSVSAVTGSVAAVGSAVSSKVSGKKKDKSD
What is the function of this protein?
May play a role in bone development.
What are the official names of this protein?
Transmembrane protein 263-A.
What is the protein family that this protein belongs to?
Belongs to the TMEM263 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PER1_SOLLC
Sequence: MGFRLSHLSLALSFVALALAGVAIYRNTYEAIIMKNGSLLKNVSPDFDSLESGVASILTLNNNKKRNSDKYLRQQLTPEACVFSAVRAVVDSAIDAETRMGASLIRLHFHDCFVDGCDGGILLDDINGTFTGEQNSPPNANSARGYEVIAQAKQSVINTCPNVSVSCADILAIAARDSVAKLGGQTYSVALGRSDARTANFSGAINQLPAPFDNLTVQIQKFSDKNFTLREMVALAGAHTVGFARCSTVCTSGNVNPAAQLQCNCSATLTDSDLQQLDTTPTMFDKVYYDNLNSNQGIMFSDQVLTGDATTAGFVTDYSNDVNVFLGDFAAAMIKMGDLPPSAGAQLEIRDVCSRVNPTSVASM
What is the function of this protein?
Suggested to catalyze the deposition of the aromatic residues of suberin on the cell wall and thus play a role in cell-suberization.
What are the official names of this protein?
Suberization-associated anionic peroxidase 1, TMP1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS18_SHIF8
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: HS60_GIAIN
Sequence: MPIYFLVLKGTGHVQALAFPKSVSDCLGRVTDTEPMLQQSIEACDRVSTETQQLLDILKQQQDDSVLEIQDTLTIAAQGLGPQQRLCAALALLHEREPSIVQQYHDVVGSLSLPEMLKTSHVARSITFHSLLHYERLCTRLHYCHLQQSVHKQKPVRMPGKLRGRWWCQESEPQQVRFGQNVRKHVVSIGGVYAQERCMTTWSTYSVDICLINLSLTRDRPASVGGLQLQVYRISASHAEPSGKRVGHIRHRAGTRQQLQEELCTKKEKLAEMTVLTQEKLSEVIKLREITMASKAESVKLACLQKLVSPQTVSRVLSFSGISYNRLILFYVRQFIFGLAWSLSCQLPLAERHSLSNLVCRYYSDYLDQPSSEVSTKTLLTLALGMQAMLTTRTTYSLISWRLRTSIQTVSTGSVRWILCLSALPTQRLLAQILRNVPWSQRRTQFQIRPISMHHRPYGYQATVQHPPPQSSYEEDGRRPPTQPAHTSLLTYVCSINSEYWQLNDPENCELRSFFFLQSIESMSTPSSH
What are the official names of this protein?
Heat shock protein 60.
Protein: DNAK_RICRS
Sequence: MGKVIGIDLGTTNSCVAVMEGKEPKVIENAEGERTTPSIIAFANGEKLVGQSAKRQAVTNPRNTIYAVKRLIGRNFIDPMVRKDQGIVPYNIVKADNGDAWVEADNNKYSPSQISAFILQKMKETAENYLGDKVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGFEKSASKTIAVYDLGGGTFDVSILEISDGVFEVKSTNGDTFLGGEDFDTRILNHLIDVFKKENGIDLSKDPLALQRLKEAAEKAKKELSSAVTTDINLPYITADSSGPKHLNIKFTRAELEKLVDDLIEKTIEPCRKALQDAGFKASDIQEVVLVGGMTRMPKVQEAVKKFFGREPHKGVNPDEVVALGAAIQGGVLNKEVTDILLLDVTPLSLGIETLGGVFTRLIDRNTTIPTKKSQVFSTADDNQHAVTIRVFQGEREMAKDNKLLGQFNLEGIPPAPRGLPQIEVTFDIDANGIVHVSAKDKASGKEQKVTIQASGGLSDAEIEQMVKDAEQNADEDKKRKELIEAKNAADSLVYSTEKTLTEYGDKLSSDDKGAVEEALAALKAVLESEDTALIKEKTASLTAASMKIGEAMYKAQSESQPAAENATNDEKIVDADFQDVEKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: LRWD1_DANRE
Sequence: MEKITEKILLEKSSTKTNKLDQIKTLNLSRMSLKSEDLPVPLLSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLTVNDEHKVIFLLPNLRMFNGKDISSTAHHIRHGSTEILRKRVIGVWERDFSLPDPISAKSLAAVEKSFVNAACTQVKYGPNSLSDYTKWRVEKIAKEYLKSLTSSEEEERVADTTPTKENKTKACDVGGNSITSPQKRTRNNTDVVAEASPRKSSRLVSAAPVEASPRKSARVLNTPQKTQPVVSSPRKHARLTSAETPESSPRKSSRLENVTQKAASQTESPRKPGMSTPTSKQAKCESPRKQSKQSTAKMEKSTPRKTTKAKLQVPQEPVSLTPLHVLQCHSRQNDPDDFSTQLWACAFEPQQDDSIDISGGSQTIATCGGETLCVINCESGLVLKKYKVPGEDFFSLAWSTVLMSRTGGSARPCNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKPTFLFTGTYDKKIFLWDIGGLDQDYNFKISKLLTLETSSTPLHLALLPSSPDTHLLSGCDEGLYCFDVQLSKNTLKRNEEIEIVFPIYKKNDKKNNYRTIDGLSFLSDDVVASKSHMQGSIYLWSWSATRASWNSRKKEVPAVILAELQWSSTDIPYLSLGTCPGYGYVVCGDEQGRLWMYHITDTMMENFKSGKTISATEVLQWPSPIRAGKGALEGPSINSTAMDPGLHYLVALTDKNMVVVWKRESH
What is the function of this protein?
Required for G1/S transition.  Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells.  Binds a combination of DNA and histone methylation repressive marks on heterochromatin.  Required for silencing of major satellite repeats.  May be important ORC2, ORC3 and ORC4 stability (By similarity).
What are the official names of this protein?
Leucine-rich repeat and WD repeat-containing protein 1, ORC-associated protein, ORCA, Origin recognition complex-associated protein.
What is the protein family that this protein belongs to?
Belongs to the LRWD1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore.
Protein: OR5M3_HUMAN
Sequence: MLNFTDVTEFILLGLTSRREWQVLFFIIFLVVYIITMVGNIGMMVLIKVSPQLNNPMYFFLSHLSFVDVWFSSNVTPKMLENLLSDKKTITYAGCLVQCFFFIALVHVEIFILAAMAFDRYMAIGNPLLYGSKMSRVVCIRLITFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKMACAGTFVKEYTMIILAGINFTYSLTVIIISYLFILIAILRMRSAEGRQKAFSTCGSHLTAVIIFYGTLIFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPMIYSLRNKDVKKAMMKVISRSC
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 5M3, Olfactory receptor OR11-191.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: METXS_BORA1
Sequence: MTSPALTAASVTPSRNTTSPDTTSHRPASVGVVSPVFLRFDEPLPLASGQSLNAYELAVETYGTLNAERSNAVLICHALNASHHVAGVAAGNPKDVGWWDNMVGPGKPVDTDVFFVIGINNLGSCFGSTGPASTNPETGLPWGAAFPVLTVEDWVRAQARVADHFGIQRFAAVMGGSLGGMQALSWAITLPERVAHCVVIASTPRLSAQNIGFNEVARRAIITDPGFHGGNYYAHDTVPHRGLAVARMIGHITYLSDDDMAEKFGRTQREPAENGAYRYGYDVEFEVESYLRYQGEKFSRYFDANTYLLITRALDYFDPARATGGDLARALSSAQADFLLVSFTTDWRFPPERSRDIVRALLKNGSPVTYAEIDAPHGHDAFLLEDARYHAVVSAYYERIARNLGLTRQAEESAA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_NOSP7
Sequence: MSAQEIIRSIEAEQLKSNLPDIYVGDTVKVGVKIKEGEKYRVQPYEGVVIAKRNGGINETITVRKVFQGVGVERVFLLHSPRIDSIKVLRRGKVRRAKLYYLRDRVGKATRIKQRFDRPL
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: APOE_CEBCA
Sequence: MKVLWAALLVAFLAGCQGKVEQVVEPELEPELEPHQQADWQSGQPWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELTALMEETMKELKAYKSELEEQLSPVAEETRARLSKELQAAQARLGADMEDVRSRLAQYRSEVQAMLGQSTDELRARLASHLRKLRKRLLRDVDDLQKRLAVYQAGAREGAERGVSAIRERLGTLVEQGRARAATVGSSLASQPLQERAQAWGERLRARMEEVGSRTRDRLDEVKEQVEEVRAKLEEQAQQMRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGASTTPVPSDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: RBS_ALVHS
Sequence: MSEIQDYNSSVSDPSSRKFETFSYLPELGVEKIRKQVEYIVSKGWNPAVEHTEPENAFDHYWYMWKLPMFGETDVDAILAEAEACHKAHPSHHVRLIGYDNYAQSQGTAMVIFRGPISAKC
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
Protein: CCD83_MOUSE
Sequence: MDSSAKGSKKDAPDGPPKDSKLPVSEALLDYHREIKENAVERFMFHIKKLREKNQKYQERNRRLKEEQNWHIKNLIKELKEKNLDEAPIVTREEVEEAMKEKWEFERQQEASLKEMRIQINEAEKLFLEKLSEKEYWEEYKNVGSAQHAQLIVSLQNDIDTVKENAEKMSEQYKVTLEDEKKRISRETMIQLKQRKEWATQHAVRFIDKNNYREIWENDWLKKEGDTASFGNVLSLLDFLPPDLHTAEPCVSSGQSRGSLRILAPFALQLWSKLSGLLPTLVTPDPVCIIWSFGPGQTNSMAICP
What are the official names of this protein?
Coiled-coil domain-containing protein 83.