Protein: TROPA_TALSN
Sequence: MDPLASNFRGETVLLFGSQSLSFDANTFNAIRSSLEKEEYLRWIRHTVADLPSALNTALQHVPHLKGSEEWAFSAVQELNDWLDSGHQPNSLDPSALPNTILTPLVVILHLSQYMKYLISANDYQDDTLLSKRQQETCETLGLCTGLLSSLAVSSSRTRLQLERYGSVAIRLAMLIGLIVDARDRSTSHGPSQSTAALWHSEEQKEKLLEILAANPEAYISVYYDQNRATITIPTAQTATIRKDLASAGLTTTEIGLRGRFHWSGHEAEVDQLIKLCDIDKRFQFTQKTALVLPNRSFDSEPHVHQGPLHAMALWSILVNPPEWQKTVSAVYASTLVSTTAKVVSFGQERCVPPTILQNLDSRVFYMGDLEKTSSPRPRGDDIAIVGASIKVAGADDLEEFWEILSKGISQHKEVPPERFTFDTVYRDRDPKTKWYGNFLNDPDKFDHKFFKKSPREAESMDPQQRLLLQIAYQALEKGGYFHNAGPDQRIGCYMGVCAVDYENNLACYAPNAFTATSHLRGFIAGKVSHYFGWTGPALTIDTACSSSAVAVHLACQAILKGECTAALAGGTQILTSPLWFQNLAGASFLSKTGQCKPFDSKADGYCRGEAVGAVFLKKMSAALADGDQILGVISGTAVQQNENCTPIVVPNKPSLSDMFQSVIEKARLQPDHITVVEAHGTGTAVGDPVEYASVRDTLGGSKRTKKLFLGSAKGLVGHCESASGIISLVKVLLMIQKGMIPPQASFNTLNPATKATPADGIEISRQLTEWNAPFRAALINNYGASGSNASMVITQAPRATTTIPGGNEMERVPFWFSALNEKSLQAYAAEFLKYLKANHGQLSLPDLGFNVSRQSNRSLPRRLLFTCQSTNELQQRLEEYVKGDSKTSSSECPATRPLVLCFGGQVSTFIGLSRQVYEDVALLRGHLNSCNRRCLALGLRGIFPAIFQKGPIEDIVTLQLSLFAMQYSCAKSWIDAGAQPVAVLGHSFGELTALCVSGVLSLDDALRMIAARAQIIRDSWGSDGGSMMALEADLDVVQKLLATSNANLPENEVAVIACYNGPRSFTIAGPRRAIDALDTSRQASPEFASIKAKRLDVTNAFHSTLVEPLRNKLTEATKELNFRERGTIHLERSTETRSEKLIDNPGSYVADHMRNPVFFHHALQRLDNQFPNAIYLEAGSSSTITNMASRALGGSGGRHFQAMSITTDKGLDNLIDATMSLWNAGLNVRFWKQAFVETENYKPLLLPPYQFEKSRHWLELKEPPKPEIITMSAGGQRTDKAPDTILSFVGYQDSNKSHARFRLNTENREYQELMKAHLIVYTAPICPATVQMDIAIEGLKTLVPGIGSEVQPQIHNVDNQTPICADKSQSIWLDMKLADEPSKISWRFRFFGTSLDNDKMPSNKQADAGVTFTLGTLVVVPMEDEQTKLDLTRYDLLTGHKRCVELLHSTEAEEILQGRTIYKTFADIVDYGEQYRGLQRLIGHGNNSVGRVVRAYNPKTWFDAHLSDAYAQVVGIWLNCMTEHDAEELYVARGFEKWIRSPDIQPTSRPDSYDVLAYHKGPSRNSCLSDIFVFHPKTGQLIEAILGFQFVRIPRKGLAKLLTRLTRDETALATNAQSRAIPPPSTNTTQSSSQQTPIPKAAAPKKEKKRPGNPKLDVLPKLITILADLVGLEPEEITINSELADIGVDSLMAMEVVTEIERVFSCSVPLDDVADVTTMSQLVRVVESIVGMEGSETSNLSSDDDDENGTPSTPETDLSDASVDAVVDNAELIAYFAESLGMDASEISANVQLKELGVDSLLSMELGGELVEKFGLNLNESTVLEDMTINDLRQTAPGAAAPKVAESTITSAPQVTTSKAVPLTNGTSFNIPVETILSAFKETKAAGDSFITATGCRGYVEQVLPEQTLLCALHTLEAFEKMGSSIRTLKAGDTMTLFTPRPEYVSLIERLTEMLETQIGLIKVIGGPGLTIERTQTPYPTASSTVLMQEMRQKYPQYQNVNELIFYVGSNLDRALRGETDGIKLIFGCAQGRELVSGLYGDWIMNICYYRQMEDFLIRLIAKLPSNEPLRILEMGAGTGGTSKWLLPLLARLGCPVEYTFTDLAPSLVAGARKTFKQYASFMKFRAHDIEQEPAEDLLGTQHMVVASNAVHATVSLVESAKKLRKVLRPNGILMMLEMIEPLYWIDMIFGLFEGWWLFADGRKHALTPPARWKTDLQAAGFGRVDWSDGNLPENSINKVIIAVACEPEKPEELDRKSVVDEFVHKYTQGVDLLSPAIRVNRKSLGHAVLVTGGTGSVGAHVVAHLAQQPFVTKVICLNRRGKLDARQRQLESLAQKGLQLSDESLAKIQVYETDLSKPQLGLSPEMYLSLLESTTDIIHNAWPMSIKRQVQGFEAQFRIMRNLIEFARDISLGGGDPLGFQFISSIATVGHYPLWKQEIRVPEDRLPLDAVLPIGYGDAKYICELMLDKTLHTYPHRFRVSTVRLGQVGGSKISGYWNPVEHLSFLFKSAQTIQQLPDLHGPLSWTPVDDVAKSLVDLLFTEKPYPVYHIENPITQPWQEMIPILADALGIPRGNRLSLKDWVARVREFPEDPTDKDKNPATALVDFFEQDFERMSVGGLLLDTTKSREHSPSLRAVGPITPDLVRKFISYWRSISFVA
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the tropolone class of fungal maleic anhydrides (PubMed:22508998, PubMed:24863423).  The pathway begins with the synthesis of 3-methylorcinaldehyde by the non-reducing polyketide synthase (PKS) tropA (PubMed:22508998).  3-methylorcinaldehyde is the substrate for the FAD-dependent monooxygenase tropB to yield a dearomatized hydroxycyclohexadione (PubMed:22508998, PubMed:24863423).  The 2-oxoglutarate-dependent dioxygenase tropC then performs the oxidative ring expansion to provide the first tropolone metabolite stipitaldehyde (PubMed:22508998, PubMed:24863423).  Trop D converts stipitaldehyde into stipitacetal which is in turn converted to stipitalide by the short-chain dehydrogenase/reductase tropE (PubMed:24863423).  The next steps involve tropF, tropG, tropH, tropI and tropJ to form successive tropolone maleic anhydrides including stipitaldehydic, stipitatonic and stipitatic acids (PubMed:24863423).
What are the official names of this protein?
3-methylorcinaldehyde synthase tropA, MOS, Non-reducing polyketide synthase tropA, Tropolone synthesis protein A.