PharMolix/UniProtQA huggingface dataset:
Protein: ATPD_BRASO
Sequence: MAAEDPSVSGVSGRYATALFELARDEKSVDAVKADLDKFNALLDESADLKRLVRSPVFGADTQLKALNAVLDKAGIAGVAANVLRVLTTNRRLFAVADVIRAFNALVAKYKGEATADVTVAEPISDKNLDALKAALKTVTGKDVALNVKVDPAIIGGLVVKLGSRMIDSSLRTKLNSIKHAMKEAG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RHOQ_HUMAN
Sequence: MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT
What is the function of this protein?
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.  In active state binds to a variety of effector proteins to regulate cellular responses.  Involved in epithelial cell polarization processes.  May play a role in CFTR trafficking to the plasma membrane.  Causes the formation of thin, actin-rich surface projections called filopodia.
What are the official names of this protein?
Rho-related GTP-binding protein RhoQ, Ras-like protein TC10, Ras-like protein family member 7A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor.
Protein: VE1_HPV13
Sequence: MAEDTGTNNEGTGCSGWFLVEAVVERTTGQQISDDEDETVEDSGLDMVDFIDDRPITHNSVEAQALLNEQEADAHYAAVQDLKRKYLGSPYVSPLGHVEQSVDCDISPRLDAIKLSRNSKKVKRRLFQSREITDSGYGYSEVEAETQVERNGEPENDCGGGGHGRDKEGEGQVHTEVHTGSQIEEHTGTTRVLELLKCKDVRATLYGKFKDCYGLSFTDLIRPFKSDKTTCGDWVVAAFGIHHSVSEAFEKLMQPLTTYMHIQWLTNAWGMVLLVLIRFKVNKSRCTVARTLATFLNIPEDHMLIEPPKIQSSVAALYWFRTGISNASIVTGETPEWIKRQTIVEHGLADNQFKLTEMVQWAYDNDFCDESEIAFEYAQRGDFDSNARAFLNSNCQAKYVKDCATMCKHYKNAEMKKMSMKQWITYRSKKIEEAGNWKPIVQFLRHQNIEFIPFLSKLKLWLHGTPKKNCIAIVGPPDTGKSCFCMSLIKFLGGTVISYVNSSSHFWLQPLCNAKVALLDDATQSCWVYMDTYMRNLLDGNPMSIDRKHKSLALIKCPPLLVTSNVDITKDDKYKYLYSRVTTLTFPNPFPFDRNGNAVYELSDANWKCFFTRLSASLDIQDSEDEDDGDNSQAFRCVPGTVVRTV
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RPO6_METLZ
Sequence: MTYTRYERARIVGARALQISMGAPVLVKTVKIDPLDIALEEFDADRVPITVKRQFGTCSEVL
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_STRCO
Sequence: MTRTPVNVTVTGAAGQIGYALLFRIASGQLLGADVPVKLRLLEITPALKAAEGTAMELDDCAFPLLQGIEITDDPNVAFDGANVALLVGARPRTKGMERGDLLEANGGIFKPQGKAINDHAADDIKVLVVGNPANTNALIAQAAAPDVPAERFTAMTRLDHNRALTQLAKKTGSTVADIKRLTIWGNHSATQYPDIFHATVAGKNAAETVNDEKWLADEFIPTVAKRGAAIIEARGASSAASAANAAIDHVYTWVNGTAEGDWTSMGIPSDGSYGVPEGIISSFPVTTKDGSYEIVQGLDINEFSRARIDASVKELSEEREAVRGLGLI
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.  Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro.  Shows a high specificity for NAD(H), being almost inactive with NADP(H).
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: SYM_NATPD
Sequence: MHEEFPTETPAVVTCGLPYANGDLHVGHLRTYVSGDAYARALESLGQSVAFVSGSDMHGTPIAVNAAEEGVDPESFAVEYHEQYEETFPQFNIEFDNYGHTHDETNTEMTRSFVRSWIDDDHVVEKEIEVAWDAEADQPLPDRFVEGTCPYCGEKARGDECDEGCQRHLEPGEIEAPVSTITGNPAEYRTRPHKFLRLSDFQEYLRGFIDRLEGTENAQNQPREWIEGELQDLCITRDMDWGIDYPADGDESGEDLVLYVWVDAPIEYVSSTKQYSEQVGRDEYDWEAVWKNQVDGVPPEGGEIVHIIGHDIIQHHTVFWPAMLRGAGFNEPRAVMACGFVNLDGDAFSTSRNRAVWADDYIESGLHPDLYRYHIITGSEFTADVDFSWDGLQERTNSELVGTLGNFLYRSLLFAERNYGGTPDAAVSDEVRNEIEAAMADFRTAVNDYRVRGLGRAPVELATFGNEYIQRHEPWKLTDDDPEKARQVIRDCVQIAKAIAVLAEPVLPGKAAALWDQLGEDGSVHDAELGAALESPPEAFDEPDELFEKLEDDRIEELNRQLEERIEAADAGDEEGEDEDEEPPAADLEPVADERISFGDFQDLDIRVAEVLEAEPIEGADDLAKLAVDIGVETRQIVAGIKQLHDLDSLSGTRIVVVANLEKAELFGVESNGMLLAAGEQADLLTTLEDAEPGTKVQ
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHDC_BACAC
Sequence: MSEATTTLDGWYCLHDLRSIDWAAWKTLSSDERGQAVSEFLNVVEKWNDVAAAKKGSHAMYTVVGQKADIMLMILRPTMEELNEIETELNKTTLAEYMVPAYSYVSVVELSNYLPADEDPYQNPQILARLYPELPKANHICFYPMDKRRQGDDNWYMLPMEERKKMMYSHSKIGRQYAGKVRQVISGSVGFDDFEWGVTLFADDVLQFKKLIYEMRFDEVSARYGEFGTFFVGNILPDEKVEKFLHI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: RL12_ENCCU
Sequence: MAEQKGMDPDTKYIKLQVVGGEVPGATLAQRVGPLGLSSKVVGEDIKKATADYKSLKVHVQLAIKDRKATVEVQPSVATLIIKSLKEPPRDRKKEKNILHNGSLRMTEVVDIARIARSSRSYSNSLSGTVKEVLGTCKSIGCKVDGKCPKEVTREIDAGEIKLPDQ
What are the official names of this protein?
60S ribosomal protein L12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: RL9_STRPZ
Sequence: MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATSQSIGELKGKQKAEEKAQAEILAEAQAVKAVLDEDKTRVQFQEKVGPDGRTFGSITAKKISEELQKQFGVKVDKRHIVLDHPIRAIGLIEVPVKLHKEVTAEIKLAITEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: SYD_XANC8
Sequence: MRTHFCGLVDETLIGQTVTLAGWTDVARNLGGVCFIDLRDHEGIVQVTVEPAEGDANSAEVFKVAASLGYEDVLQVEGVVRARHAVNDKIRTGKVEVIATRITILNKAAPLPFHAHENPGEDTRLKYRYLDLRRPEMQRMQRTRIKLVQALRRHLDARDFQDIETPILTKATPEGARDFLVPARMHPGEFYALPQSPQLFKQILMVAGFDRYYQIARCFRDEALRADRQLEFTQLDMEFAFVRERDVQDFVEDMIRAIFKEVVDVELAAQFPRMTWAEAMRRYGSDKPDLRIALELVDVAELVKTSEFPVFAAAANDADGRVAALRIPGGATLSRKQIDDYAAHAAKYGAKGLAYSKLSETGEVSSPIAKFFGEEAFAALLAHVGAANGDIVFFGAGSYNKVSDFMGALRLKAGKDFGLVAAGWAPLWVTDFPMFEWDEEAQRYVALHHPFTAPAVDDIADLRANARTAVSRGYDMVLNGNEIGGGSIRIHRPDMQSAVFELLGIGAEEARAKFGFLLDALNYGAPPHGGIAFGIDRIAALMAGTESIRDVIPFPKTTGAQDLMTDAPSPIAAEQLAEVHVQVRPKQA
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_PECCP
Sequence: MASSNLIKQLQERGLIAQVTDEGALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQLAGHKPVALVGGATGLIGDPSFKATERKLNTADTVGEWVEKIRRQVSPFLDFDCGKNSAIAANNYDWFGGMNVLDFLRDIGKHFSVNQMINKEAVKQRLNRDDVGISFTEFSYNLLQGYDFASLNKQHDVELQIGGSDQWGNITSGIDLTRRMNQKQVYGLTVPLITKSDGTKFGKTEGGAIWLDASKTSPYKFYQFWINTADADVYRFLKFFTFMSLEDIDALEEEDKNSGKAPRAQYVLAEEVTRMVHGEAGLEAARRITQSLFSGALQDMTQDDFAQLAQDGMPIIELENGADLQQALVSAELVPSRGQARTMISSNAVTINGEKQADPEYTFSASDRLFDRYTLLRRGKKHYCLICWKA
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIR2_SCHPO
Sequence: MSEVHQESEVEYSRWKRERSPERSQRRSQSPPGEQSAYHRERSPLRKRGNYYDDRTRASGPYPTFTKPLIDPYTQTNAVSYERFIRWYSKENHISATTEDLYNSLHGTYNNYKQDLYARTARSFVESHCDEAWFEDSYWVDESQGRVLEVSENEKSYRRALYDKFMDRLDAGYYDDFQLPTAEDVIEKPSIPDNDTDDSILPSNDPQLSKWNQDSRNDAMENTLLVSHVLPNISVAQIHNALDGISFVQHFSLSTINLIKNDERSLWVHFKAGTNMDGAKEAVDGIQLDSNFTIESENPKIPTHTHPIPIFEIASSEQTCKNLLEKLIRFIDRASTKYSLPNDAAQRIEDRLKTHASMKDDDDKPTNFHDIRLSDLYAEYLRQVATFDFWTSKEYESLIALLQDSPAGYSRKKFNPSKEVGQEENIWLSDLENNFACLLEPENVDIKAKGALPVEDFINNELDSVIMKEDEQKYRCHVGTCAKLFLGPEFVRKHINKKHKDWLDHIKKVAICLYGYVLDPCRAMDPKVVSTSYVSLQILNKPYVGFRNINANYTFPTTSYSRRNDEEITSGASSQKSYSRQEPMIHRREFYRTYQDLDAPNQEVPELDY
What are the official names of this protein?
NURS complex subunit pir2.
What is the protein family that this protein belongs to?
Belongs to the ARS2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BWR1B_HUMAN
Sequence: MGELPGSEGMWENCPLGWVKKKASGTLAPLDFLLQRKRLWLWASEPVRPQPQGIHRFREARRQFCRMRGSRLTGGRKGFGSSGLRFGRGGFSEEVMPQPVLKAMRCAEGAWWFSPDGPAGSAASIWPAEGAEGLPGQLGRDRLEVVYSVPDNVPGQNGSRRPLVCKITGKCLSVCSEENAKAGGCSAFPLLLSQLGARMTGREHAHKGPELTTPDSGLPRPPNPALAGFRALAQHSPPLGTSTPSAVLLSAAT
What are the official names of this protein?
Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein, Organic cation transporter-like protein 2 antisense protein, Solute carrier family 22 member 1-like antisense protein, Solute carrier family 22 member 18 antisense protein, p27-Beckwith-Wiedemann region 1 B, p27-BWR1B.
Protein: SELA_HELPY
Sequence: MAKETLEITPDLLKNPYQKIINASASVFDEKHGRSFFSTQFYEKIEPYLKEVLTHPIDLECDLNTAKKKNRLTPLKQLFKACFNTEEILIVNNNTSAIFLIANALAQEKEIIVSYGELVGGDFNLKDILLNSGARLHLVGNINRAYLRDYRLALNENSKILFKTHNPHFKKDTPFKDLQTLAKEHDLIDYYNLGDVDLSNRVALEEILALKPSLLSFSADKFFNSAQAGIIMGQKERVEALKNHPLYRVLRVGKITLTLLFCSLKAWINHQEDITIHALLNQTKDALLQKALKLYALLKPLELNVSIASSFSKIGNLFGRELESFCVKIQPKNTRALNSEKLYLKLFQKGVIARISCEFVCFEVFSLNEKDFEKIALVLEEILNKA
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFT1B_HUMAN
Sequence: MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAYVKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF
What are the official names of this protein?
Interferon-induced protein with tetratricopeptide repeats 1B, Interferon-induced protein with tetratricopeptide repeats 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the IFIT family.
Protein: GLGB_DEIGD
Sequence: MLDPLRASSPATLALMSSLPLPLDHGHLQKLVTADLVRPDHLLGAHPVTENGVEGVRFAVWAPRAQHVSVVGDFNGWNGFDHPMQRLDFGFWGAFVPSARPGQRYKFRVTGADGRTVDKMDPYGAFTEVRPNTASIIWPLAFEWTDDAWMQKRTPGFDRPISIYEVHVGSWARRDDGWFLNYRELAHRLADYVTFMGYTHVELLGVMEHPFDGSWGYQVTGYYAPTSRLGAPEDFAYLVNHLHERGIGVIVDWVPGHFPTDEAGLAHFDGAPLYEYSDPRKGYHYDWNTYIFDYGRNEVMMFLIGSALKWLQDFHVDGLRVDAVASMLYLDFSRTEWVPNIHGGRENLEAIAFLKRLNEVVHHMAPGCMMIAEESTAFPGVTSPTPFGLGFDYKWAMGWMNDTLYYFEQDPLWRKYHHHKLTFFNVYRTGENYILAISHDEVVHLKKAMVSKMPGDWYMQRAGYRAFLAMMWTTPGKKLLFMGQEFAQGTEWNHDEALPWDVTDLPEHRGVMNLVRRLNGLYRERPDLHIGDTWEEGQLWVSADDTDNSVYAYIRRDPRPQAEGGGAWSLAVANLTPVYREGYPIGVPQGGEYRVLLSTDDGEYGGFGTQQPDLTAKEEGWNGQTHHLRLNLPPMSVLLLEHVGVTPRSEDR
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: DNAJ_CHESB
Sequence: MKADFYETLCVSRNADEKELKSAFRKLAMQYHPDRNPGDMEAEKKFKEINEAYETLRDPQKRAAYDRFGHAAFEQGMGARGGFNGGGFADIFEDIFGDIMGGARQRRSGGRERGADLRYNMEITLEESFTGKTAQIRVPTAVTCDECAGSGARPGSSPVQCPMCHGAGRVRASTGGFFSIERTCPQCQGRGQIIDDPCRKCSGQGRLTEERSLSVNIPAGIEDGTRIRLAGEGEAGLRGGPPGDLYIFLSIKPHEFFQRDGADLYCKVPISMTTAALGGSFEVTTLDGTQTRVKVPEGTQSGRQFRLRGKGMPVLRQPQVGDLYIQVAVETPQNLTRRQRELLEEFEKISSGENSPQSTGFFARMKDFFETFGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP90_CAEEL
Sequence: MSENAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIKITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDFLEERKIKEIVKKHSQFIGYPIKLVVEKEREKEVEDEEAVEAKDEEKKEGEVENVADDADKKKTKKIKEKYFEDEELNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPQRAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRYSTSAGDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKVEKVGVSNRLVSSPCCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKDLVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLDIGDDEIEDSAVPSSCTAEAKIEGAEEDASRMEEVD
What is the function of this protein?
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.  Undergoes a functional cycle that is linked to its ATPase activity.  This cycle probably induces conformational changes in the client proteins, thereby causing their activation.  Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.  In response to cellular stress, up-regulated in distal tissues in a pqm-1-dependent manner, preventing protein misfolding and maintaining proteostasis (PubMed:29949773).  By stabilizing the receptor-type guanylate cyclase daf-11 or another signal transduction component that regulates cGMP levels, plays a role in dauer formation and chemotaxis to non-volatile and volatile attractants detected by AWC sensory neurons (PubMed:10790386, PubMed:7828815).  Participates in the control of cell cycle progression at the prophase/metaphase transition in oocyte development by ensuring the activity of wee-1. 3 kinase, which negatively regulates cdk-1 through its phosphorylation (PubMed:16466390).  Regulates yap-1 nuclear export after heat shock treatment (PubMed:23396260).
What are the official names of this protein?
Heat shock protein 90, Abnormal dauer formation protein 21.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Note=Perinuclear region of somatic cells.
Protein: TSAD_PSE14
Sequence: MLVLGLETSCDETGVALYDSERGLLADALFSQIDLHRAYGGVVPELASRDHVKRMLPLIRQTLAEADCVATDIDAIAYTAGPGLVGALLVGASCAQALAFAWDIPALGVHHMEGHLLAPMLEENPPQFPFVALLVSGGHTQLVRVDGIGQYELLGETLDDAAGEAFDKTAKMMGMQYPGGPEISKAAMQGVAGRFVFPRPMTDRPGLEFSFSGLKTSALNTWQQCQGAGDDSEQTRCDIALAFQQAVVETLTIKCKRALKQTGLKSLVIAGGVSANKALRASLESMLGDLRGNVYYARPEFCTDNGAMIAFAGCQRLQAGQKEDLSISVQARWLMEQLPGL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XNI_COLP3
Sequence: MSAHLILIDALNLIRRVYAVQERPFIQIKQDHDDELSASTLKQVLFNTQNTCVNALIKIIDQHQPTHALTVFDSQEPCWRYQLFEGYKKGRKKMPDHLANKLIDIQDAFMEQGVDSLTSDEDEADDLIATLAVKMALHGQKVTIISTDKGFLPLLSPNIHIYDYFNRRYLDEEHVQSKFSVKTSQLIDFWTLTGDNTNKIEGVSGIGQVTAAKLLNQYGSLKAILEATDLKDSLAEKLTQSLEQMDLARKLLTLKQDIPLGFNLKDIRLTTSSSAHEINANINLTTDDKS
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: FDL20_ARATH
Sequence: MKNSERFSAAKPLMEQGGKSSRKPGFMSEDRISELPEVLLLQILSSLPTKLVISTSVLSKRWLSLWKMVQRLEFESSRNIYDFAENVTRSLLSHKAPVLESLHLKVGDQFDGVYVGVWATIAFTRHVREFVLDLSSYHGPRVRFPTSLFCFDTLETLKLDYVYIYVPCPVSMKSLRTLHLLSVVYKGDESGHNLFASCPNLEHLVLRRGFFFDAVVNFIIDAPSLKTLLLSDPFSARESSRGYVIKAPSLKYLGIESVEGFEYFLIENVTELVEANIRNVSKIVNENILGSLKSAKRLSLDLSPLKITYPTEVMYHQLVYLEMHTHKVEWWNLLTHMLDSSPKLQVLKLIDRETRHENLEFDKKYKDQGKWNQPKYVPECLETFMWRNCNWGREEEKEVATYILRNARQLKKATFSTDPIEAKRLCKLAKRRKMREELDGVVMTSNSCHLVFEFE
What are the official names of this protein?
F-box/FBD/LRR-repeat protein At3g51530.
Protein: Y5482_PSEAE
Sequence: MLSWAITFLIIAIIAAVLGFGGIAGAATGIAKILFVLFLVLFVVSFFFGRRRG
What are the official names of this protein?
UPF0391 membrane protein PA5482.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HES1_YEAST
Sequence: MSQHASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLLVKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRWFKQVDYMNENTSNDVEKASEDDAFRKLASKLQLSVKNVPSGTLIGGKDDKKDVSTALHWRFDKNLWMRENEITI
What is the function of this protein?
Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes.  Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol.  Involved in maintenance of intracellular sterol distribution and homeostasis.  Plays a role in ergosterol synthesis (PubMed:15173322, PubMed:11238399, PubMed:16408938, PubMed:20008566).  Binds and transports sterol (PubMed:20008566).  May be involved in ergosterol transport from the plasma membrane (PM) to the ER (PubMed:16585271).
What are the official names of this protein?
Oxysterol-binding protein homolog 5, Homologous to KES1 protein 1, Protein HES1, Oxysterol-binding protein-related protein 5, ORP 5, OSBP-related protein 5.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
What are the subcellular locations of this protein?
Vacuole membrane. Bud neck.
Protein: RL1_METSB
Sequence: MAHIGKRISKAREGIDRVKLYPIRDAIALIKERASAKFDETVEIAMNLGVDPKHADQMVRGVVNLPNGTGRTLRVAVFARGAKADEATAAGADIVGAEDLVATVQGGTIAFDRCIATPDMMPLVGRLGKVLGPRGLMPNPKVGTVTMDVAAAVKASKGGAVEFRVEKAGIIQGSVGKASFDDDKLAENIAAFVDAVAKAKPQGAKGTYIQRVAISSTMGPGVKVDPATLTA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: FGR41_CANAL
Sequence: MKISNLIPAYLLPFSLFCQVLGAPTNGKRGNVVVVKVKTTVQQTQTDIQTISEATGTTTNYLINTSTETFTRYTATVTSTVYGVPHTYTTVATTPVSAADVIPNSENEVKSSPTESPVEQETSTSSTSVATTTTPVAKNPVSSQETSTPTPVPPETTSTSSSLLSSSQQTTTLAQVSETAINDTTESSGPTITGSVSSQTTDSWIIENISTVTSDGTCFVNYDYYYATETDDAEETTTLTSTITTTVTLN
What is the function of this protein?
Putative adhesin which may be involved in cell adhesion and virulence (By similarity).  Involved in the regulation of filamentous growth.
What are the official names of this protein?
Filamentous growth regulator 41, GPI-anchored protein 35.
What are the subcellular locations of this protein?
Secreted. Cell membrane; Lipid- anchor, GPI-anchor.