PharMolix/UniProtQA huggingface dataset:
Protein: GSA_SYNC1
Sequence: MSYSRSHQFFERARKVIPGGVNSPVRAFKAVGRQPLFIERAEGCTLVDADGNRYIDYVGSWGPMIVGHSHPKVVEAICDAAARGTSFGAPTALEIELAEQVCAAFPNMESVRMVSSGTEATMSAIRLARGVTGRDKILKFEGCYHGHADSLLVDAGSGVATFGIPASPGVPADFARHTLTAPYNDLGRVRALVEEHKADLAAIILEPIAGNMGCVPPQPGFLEGLRALCDQHEILLIIDEVMTGFRVSYGGAQQLYGVRGDLVCLGKVIGGGLPVGAFGGRQDIMRHLAPDGGVYQAGTLSGNPLAMSAGIATLKLIREEGVYEQLEQRSAYLAEGLRQAAAAAGVPACLQRVGSMFCNYFQTGPVTSFADAKASDTEAFARYFGQMLDNGVHLAPSQFEAGFVSLAHTVEDIDRTVEAAHRSLKAI
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SET5_ASHGO
Sequence: MGQSSLKLETIPLNDCHFSDAAPVGSVIPTESEVYDAVAQLWRQEPELERAGWEEWRARLKAIHPGWSLSVAHICRTLEKHCMSITGITQFTYHELVTSKESPALREPHLAKVQVTWSEKGKGLVARRPLAKGELVFAEDALSFIPPLEKSTLVHLSKACGSCGTSLSQNRYYYVMNNLDCDNCTTIWCTKGCRNLDTTHDFLKHPMSRNKRCSAQKWLKFEQFCKENTWHSAYSVGVMFARYYLHSDRRLQGNFESLAEVSQRVRLHAADTMNSGAAFDLGVDLTANAQSVCMWEEGYGLFCDAFPLAKDEYDLDFEKFLRYVGKFNLNQVNGQIYMLLSHLNHSCEPNIYYELEGHHINVYARKEIKSDEELTVSYVNPLHDVDLRRRELRVNWGFLCLCDRCKREISKKNIDKAGHSSTTAGPEPQSYRGHRRKSSLRASKPTLQDLLENGKEFDIEIPSQPGFAARRASVRFDSKVVTAVEERQ
What is the function of this protein?
Putative protein lysine methyltransferase.
What are the official names of this protein?
Potential protein lysine methyltransferase SET5, SET domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MATRX_IHNVW
Sequence: MSIFKRAKKTVLIPPPHLLSGDEERVTILSAEGEIKVTGRRPTTLEEKIYYSMNLAAAIVGGDLHPSFKSMTYLFQKEMEFGSTQEKVNFGSRKPAPQTTYQVTKAREVYLQTQPLEKKIPMQTYSVSTEGATITFTGRFLFSSSHVGCDDNRTKLAGLDGFTTSNSYQRVKDYYAQETALALTFAAPEKRGKEK
What is the function of this protein?
The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
What are the official names of this protein?
Matrix protein, Protein M2.
What is the protein family that this protein belongs to?
Belongs to the novirhabdovirus matrix protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=During bud formation, associates at the inner side of the plasma membrane of infected cells.
Protein: Y3010_ECOL5
Sequence: MPGCTSRLLPEGPFSRNQALAVTTAYLNVLIEDDQGTHFRLVIRNAEGQLRWRCWNFEPDAGKQLNPYLASEGILRQ
What are the official names of this protein?
UPF0401 protein ECP_3010.
What is the protein family that this protein belongs to?
Belongs to the UPF0401 family.
Protein: MTNB_PENRW
Sequence: MCPADQTVATNNNDHLVQSEDPEHPANLIPELCRKFYNWGWVTGTGGGTSIRQGDHIFIAPSGVQKELMQPHNIFVLQWPTPKYPASERNYIRKPLKLNPSACTPLFLTAFEQGAGCCIHTHSQWAVLVTLLVEREKGPDACFEISNIEQIKGIPRGKGKGMLGFFDTLKIPIIENTAFEEDLTSGLEAAMNKYPDAYAVLVRRHGIYVWGDNTAKAKTQCESLDYIFQLAVEMHKLGLPWVK
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_PELTS
Sequence: MLILVVGLNHRTAPVEVREKLSFSAKSLQGALAQLKSYPVIEGCAILSTCNRTEIYAATLEMDDGLNAIWDFLSRWSGVGISEIKNFTYSHTLYDTIRHLFRVAAGLDSMILGETQILGQVREAYQRAIEYESTNRVLNTLFQQAITVGKRVRTETGIDRNAVSISYAAVELARQHLGSLDGRSVLVIGAGKMSELTARHLVANGVSSVIVSNRSFERAVALAEQFRGRAVRFDELYRCMEAADIVISCTAASHCVVKAEEVSRVMDKRRGRAIFMVDIAVPRDIEAEVGNLAGVTLFDIDDLKNVIDQNLAERKQAAVKAEEIIEEELDGFMKWLGMQFVVPTISALKKWGDEIKQKELCRALNRLGNISEHDRKVICSMANSIVNQILHVPVAQLKSYALTTEGHLYTEILQNLFNLDVPGQKPKKQPAPAGIKEPVLAKKG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RL3_METHJ
Sequence: MPTIHRPRMGSLAYSPRKRAKSPVPKYHAWPAYQGEPALQGFAGYKVGMTHVIMVDDHAHSPNEGKDIMVPVTVIEVPDMRVAAIRVYRHDTYGNHVLTEVWADSFDKELSRRLNLSKNYKREEAEKKIREALEADKIVDVVALTYTRPSVLTGVPKKVPDLMETRIDGGSMTERFEYGLSMLGKDFDIRSLFKVGQYTDVTAITKGKGTQGPVKRWGVHLRKRKHSRGKKERHVGTLGPWTPHHVRWQVPMMGQMGYHQRTEFNKRLLKIGEDGAEITPEGGFINYGEVRARYVLIKGSVPGPSKRLVRIRHAMRLGEHKIREPTIGFISLESKQG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: HUTH_BRUSU
Sequence: MTIILKPGSVPLETLEKIYREGLPVRIDPAFHAGIEKAAARIAEIAAGDAPVYGINTGFGKLASIRIAAGDVATLQRNLILSHCCGVGEPLSENIVRLIMALKLVSLGRGASGVRLEVITLIEAMLEKGVIPMIPEKGSVGASGDLAPLAHMTAAMIGEGEAFYRGERLSGAKALGKAGLKPVVLAAKEGLALINGTQTSTALALAGLFRAHRAVRTALITGALSTDAAMGSDAPFHEEIHQLRGHKGQIDAGRALRTLLEGSAIRRSHLEGDQRVQDPYCIRCQPQVDGACLDILRQAARTLEIEANAVTDNPLVLSDGRAVSGGNFHAEPVAFAADQIALAVCEIGAISQRRIALLVDPSLSFGLPAFLTRKPGLNSGLMIAEVTSAALMSENKQMAHPASVDSTPTSANQEDHVSMACHGARRLLQMTANLNAIIGIEALTGALGVELRKPLTTSAELAKVIAALRAKVVTLEEDRYMADDLKAAAELVADGTLSGVISAGILPDLEA
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_RUTMC
Sequence: MNRYYDKNADLNIIKGMKVSIIGYGSQGHAHANNLKDSGVEVVVALRADSASTEKAFVAGLTVKSIEEATDWADLVMVLAPDEFQAKIYTNSIEPNLKQGATLAFAHGFNIHYNRIIPRTDLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAVFQDASGNAKATSLSYACAIGGGRTGILETSFKDETETDLFGEQVVLCGGTTALVQAGFETLVEAGYEPEMAYFECLHELKLIVDLMYEGGIANMRYSISNTAEYGDVTRGPRIVTADTKTEMKKILSEIQDGTFAKEFVANVDELPAHRDVQRKHQIEQVGESLRSMMPWINKNKIVDQSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: HEM1_PSEA6
Sequence: MTLIAFGINHKTAPVELREKVAFSPDAMVEALKSLAHLTGADESVIVSTCNRTEIYAQAENLTADALTTWLAEFHQAKADELGLNSYIYHQEDAIKHIMRVACGLDSLILGEPQILGQVKQAFVSAKDSGVIKSDFERLFQQTFSVAKRVRSETEIGSNAVSVAYASVQLAKHIFSSLKKSNVLLIGAGETIELVAKHMHEQGVKKLSVANRTLARAEAIAQPLGATTLTLTQIPAHLKDADIVISSTASQLPILGKGLVERALKDRRHKPMFLVDLAVPRDIEAEVGELDDAYLYTVDDLQQIVEKNIESRQHAALQAQQMIEEQAQQYMLWRQGQSSIDVLRDFRQQSESQRDTLIAKALNQLADGKEAEQVIKELANKLTNSLIHAPTKALKKAAMQQDNKNMSLLQDALGLARANDSSK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RACG_ENTH1
Sequence: MRPVKLVIVGDGAVGKTCMLISYTTNAFPNEYIPTVFENYNSSLVVDDVKINLGLWDTAGQEDYDRLRPLSYPSTDVFLVCFSVIAPASYENVEGKWKPEIDQHCPNVPIILVGTKIDIRDDPEQVKRLAEKNIVPIQPPQGDELAKKIGAVKYIECSALTQANLKLVFEEAVRAVLAKAAKEPTGKKEKGGKKGCSLF
What is the function of this protein?
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states (By similarity).  Involved in actin cytoskeleton remodeling during capping of surface receptors and uroid formation (PubMed:9601102).
What are the official names of this protein?
Rho-related protein racG.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
Protein: PYRG_HYDS0
Sequence: MHVSNSKFIFVTGGVLSSLGKGVASASIGALLEGLGLSITLQKLDPYLNVDPGTMNPYQHGEVFVTEDGAETDLDLGHYERFTNTNLSKLNNITAGKIYNSVLEKERKGAYLGSTVQVIPHVTDEIKSMILKASKDKDIAIVEIGGTVGDIESLPFLEAIRQLQLEIGKENTLFIHLTYVPYISVAGELKTKPTQHSVKELRAIGIQPDIIICRSEVELPQDVKSKIAMFCNVKPENVISAYDVDYIYKIPLILKAQNLDKIIIDAFRLENKEPNLTKWENIVSSLEHLKDSVDIAIVGKYIKLKDAYKSLIEALIHGGIEHKLKVNMIWVDSENLNEKDLEHVDGILIPGGFGERGIEGKIRALNYGRTKNIPTFGICLGMQLMAVEFARNVLGFKDANSTEFDPNTSNPVIDIMEEQKGIENLGGTMRLGAYECLIKENTKAYEIYKENLIYERHRHRYEFNNKYKEHFEKHGFIASGIYPKKSLVEIIELQNHRWYIGCQFHPEFKSKPFKAHKLFASFIENAYIYKKERS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: DBP3_EMENI
Sequence: MAKREHQDQTGDSRPSKKSKGTKDTKKNTEVSPPYFQSPALDNVPQTEIDKFLSDHSIKITDASADKPSLRPIISFSFLPPSNKDLYAPLDGFASPTAIQSATWPLLFAGRDVIGIAETGSGKTLAFGLPCLKKVLDLKTKQKSCRPLAVVISPTRELAMQIYDQLVKFAEKVDIQVACIFGGVKKDEQREALKSAAVVVATPGRLKDLQNDGSLDLGRVKYLVLDEADRMLDKGFEQDIKDIISPMPVSKRQTVMFTATWPPIVRNLASTFMTSPVTVTIGGDPSADPRANSRIKQVVEVVKPHEKEQRLVQILNRHQRGTPDKVLAFCLYKKEAMRVERLLRTKGFKVAGIHGDLSQQERFRSLEAFKSGAATVLVATDVAARGLDIPHVKLVVNVTFPLTVEDYVHRIGRTGRAGADGHAITLFTETDKAQSGALINVLKAANQEVPEALLKFGSTVKKKQHDAYGAFFKDVEPGKAATKIVFDD
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase dbp3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: UXUA_BRUC2
Sequence: MRQAWRWFGPEAGVPLDAVRQAGATDIVSALHEVPIGQEWTSAQIVERKNLIESTPTGRHPLTWSVVESIPVSDDIKRSGKAARHDIGAWIASMEALARNDIKVICYNFMPVVDWCRTDLDYITSTGATAMRFDQDRFAAFDLHILQRKGAEKDYSEEDRIAARAIFEAMDETEIEQLIVNIASALPGSTTEPLTIPAFREKLETYASIDAAHLRRNLVEFLEAVTPVADSLGVKLTLHPDDPPRSLFGLPRIASTEADYAAIFAAVPAQSNGMCFCTGSLGVRADNDLPAIARRFASRIHFSHLRATTREGDGRTFHEAAHLEGDVDMVGILRILLEEDRKRDAGQTIIFRSDHGHRMMDDLEKKVTPGYPVIGRMRGLAELRGIITALDACALEYDPNV
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: LXRA_ASPNA
Sequence: MSRSLEGKFAIITGGSRGIGEAIAHNLASKGCSLLLNYTSDSSRTRTESLCNTLSTTHKITCIPVQADLSDPAPAVNTIISAAKTHFTSPTTNTLTIDILINNAGVSKDRFLNDPSSGPIDPAYFNWHYTINVLAPLLLTQACAEYLPRKPAHSGRIINISSISSSLGFTGQSVYGGTKAALEAMTRTWARELADVATVNAVNPGPVVGDMYFATGEEFWKQMQGFQDNTPLSKLVDGEEAVEELLSEEQKRLIREKMGGRRPAFTREIAGVVGMLCTEDGAWCTGSVVCANGGLKFT
What is the function of this protein?
L-xylulose reductase involved in the catabolism of L-arabinose through an oxidoreductive pathway.  Catalyzes the NADPH-dependent reduction of L-xylulose.
What are the official names of this protein?
L-xylulose reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PIMT_PYRHO
Sequence: MMDEKELYEKWKRTVEMLKAEGIIKSEKVERAFLKCPRYLFVEDRYKKYAHVDEPLPIPAGQTISAPHMVAIMLEIADLKPGMNVLEVGTGSGWNAALIAEIVKGDVYSIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKSPYDAIIVTAGAPEIPKPLVEQLKPGGKLIIPVGSYHLWQELLEVIKREDGSIKIKNHGGVAFVPLIGEHGWRE
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins (By similarity).
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_GEODF
Sequence: MKKATTILDIQKMKAEGEKISMLTCYDYPTARIMDDCGIDMILIGDSVGVVYAGYDNTLPVTMEDMIYHTRAVVRAQPKALVVADMPFLSYQTDMVSARLNAGRLIKEGGAAAVKIEGGVNVAPVIEAITSMDIPVVAHIGLTPQSLHRMGGYRVQGRNNEQAEKLLADARAVESAGAFAVVLEGIPAALAARITSESGIPTIGIGAGPSCDGQVLVIHDILGLCEKYAPKFVKRYADLKPVIAQAISSYIQEVKEGAFPTEGNSFN
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_CHLPB
Sequence: MDKNSVIGLVLIGLIMIVWMQFMAPENKPVPERMTADVTGVEETSAKSGTGSPAVAVSAVPETFGEFSAATEGEEKLLTIDNELFTAVLSSRGATLKSMVLKKHLNANRERFDLIKNSDSGALSLFFQTSDGKNIDTRDLYFEPSDTQKTVSLTGEESYTVTYRLDVAPEKSITIVYTFTGDVYGINYDVQFTGFDGVLPGNEYQLEWDGGLLYSEKNIDDELQNSWASAYMGGSLLKLDASDPSKEYREEQSGVAGWIAVRSKYFVASLIPSSPTDGVYLKGSGKPGEKFEDYTAALKFTLPQNEKTHSESLVLFVGPVDYNVLHSLNVNLEKIMDFGWDWLTRPFAEYIILPIFDLLSKLTSNYGLIIIIFALLIKLVTYPLTMASTKSMKKMAALQPMMKELQEKYKDNPQKMQSELGRIYKEAGVNPLGGCLPVLLQMPLLFAMFYVFRSSIELRQQSFLWAKDLSLPDSILDLGFSIPLYGDHIALFPILMGGAVYLQQKITPTAQSNDQMKAMLYIFPVMMLLFFNNLPAGLGLYYLMFNVFSIAQTFYINKTSSADDLPKISLEKQGQKPQKKKKGGKKQ
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GALC_XENTR
Sequence: MRTVLAGSRRAPGCGEGMFILWLVLLLFPGAPAQYSVDDLGGLGRMFDGIGAISGGGATSRLLVNYPEPQRTEILDYLFKPNFGASLHIFKVEIGGDAQTTDGTEPSHMHYPDDQNYFRGYEWWLMKEAKKRNPAIKLIGLPWAFPGWIGNGKNWPYDFPDVTAYYVVSWIIGAKQYHNLDIDYIGIWNERAYDIKYIKLLRYTLDKNNLEHVKIIASDNLWQPIAFHMLQDPELLRVVDVIGAHYPGTHAAQDAILTGKTLWASEDYSTYNDEVGGGCWARILNQNYVNGNMTSTISWNMVASYYEQLPFGLEGLMTAKEPWSGNYVVSTPIWITAHTTQFTQPGWYYLKTVGHLDKGGSYVALTDRLGNLTIVIETMSHNNSICIRPPLPDYNVSAQYATFYLQGSFKNLQELQVWYSSLDINNTKPVTFKKLSPLKVQNGSFTLQLGVNEVYTITTLLTGQKGSFPDPPESKPFPLKYKDDFSVRNPPFSEAPYFADQSGVFEYFTNTSDPGDHVFTFRQVLTQRPITWASDANQAISVIGNYQWSNVTVTSDIYIETPDTGGVFVAARVDQGGSPTDRAKGIFFWVFADGTYKVTGDLMGQTILCKGLAGVRARSWHTLTLHIDGTNAFGLLNGNPLWKEVVTGGPLNGWAAIGTSCFEFAQFDNFMIEVKDSE
What is the function of this protein?
Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine.
What are the official names of this protein?
Galactocerebrosidase, GALCERase, Galactosylceramidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 59 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: RLMH_METPB
Sequence: MRLLVVAIGRLKNGPERDLAARYRERAVALGKSLGVTACDLTEIPESRARRAADRVAEEAAAILALVPADAAVIACDERGRSDWPSERIAEKIGGWRDAGRGSLVLVIGGADGLHESVRGRADHILAFGAATLPHGLVRVLALEQVYRALTILAGHPYHRGDPEA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: USP_ARATH
Sequence: MASTVDSNFFSSVPALHSNLGLLSPDQIELAKILLENGQSHLFQQWPELGVDDKEKLAFFDQIARLNSSYPGGLAAYIKTAKELLADSKVGKNPYDGFSPSVPSGENLTFGTDNFIEMEKRGVVEARNAAFVLVAGGLGERLGYNGIKVALPRETTTGTCFLQHYIESILALQEASNKIDSDGSERDIPFIIMTSDDTHSRTLDLLELNSYFGMKPTQVHLLKQEKVACLDDNDARLALDPHNKYSIQTKPHGHGDVHSLLYSSGLLHKWLEAGLKWVLFFQDTNGLLFNAIPASLGVSATKQYHVNSLAVPRKAKEAIGGISKLTHVDGRSMVINVEYNQLDPLLRASGFPDGDVNCETGFSPFPGNINQLILELGPYKDELQKTGGAIKEFVNPKYKDSTKTAFKSSTRLECMMQDYPKTLPPTARVGFTVMDIWLAYAPVKNNPEDAAKVPKGNPYHSATSGEMAIYRANSLILQKAGVKVEEPVKQVLNGQEVEVWSRITWKPKWGMIFSDIKKKVSGNCEVSQRSTMAIKGRNVFIKDLSLDGALIVDSIDDAEVKLGGLIKNNGWTMESVDYKDTSVPEEIRIRGFRFNKVEQLEKKLTQPGKFSVED
What is the function of this protein?
Required for the synthesis of the intine, the pectocellulosic inner wall of developing pollen.  May function as the terminal enzyme of the myo-inositol oxidation (MIO) pathway.  May also play a role in the salvage pathway for synthesis of nucleotide sugars (PubMed:16557401, PubMed:16757173, PubMed:23373795).  Can use a wide range of substrates including glucose-1-phosphate, galactose-1-phosphate, xylose-1-phosphate, arabinose-1-phosphate and glucuronate-1-phosphate (PubMed:17341835).
What are the official names of this protein?
UDP-sugar pyrophosphorylase, AtUSP.
What is the protein family that this protein belongs to?
Belongs to the USP family.
Protein: RLMM_SALPC
Sequence: MNKVVLLCRPGFEKECAAEITDKAGKREIFGFARVKENAGYVIYECYQPEDGEKLISELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELMKFCRKFTVPLRAALRDVGVLTNYETPKRPVVHVFFIAPGCCYTGYSFAHNNSPFYMGIPRLKFPSDAPSRSTLKLEEALHVFIPEDEWDERLANGMYAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFRYRPNRNNISWMVCDMVEKPAKVTALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYLQAQLDEHGVNAQIQARQLYHDREEVTVHVRRLWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_BRUA2
Sequence: MAQAFQFELVSPERLLLSAQVTEVVIPGSEGYLTALAGHSPLMTTIMPGVVSVKLADGKTDSYVVFGGFADITPQGCTVLAESATHVDDIDPADIQHRIDHARKVLEDASSNEHRTKAEIFLHQLMTLQGAILPA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PORCN_MOUSE
Sequence: MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
What is the function of this protein?
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins.  Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
What are the official names of this protein?
Protein-serine O-palmitoleoyltransferase porcupine, mPORC.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CDC37_DROME
Sequence: MVDYSKWKNIEISDDEDDTHPNIDTPSLFRWRHQARVERMAEMDHEKDELKKKRQSYQARLMDVKERISKKDGDEEALKKELEKIEAEGKELDRIESEMIKKEKKTPWNVDTISKPGFEKTVINKKAGRKPDENLSEEEREQRMKQFVKENEKLCQQYGMLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSKIQHCHPEYRAQFDSEIEGFKGRIQKRAQEKIQEAIAQAEEEERKERLGPGGLDPADVFESLPDELKACFESRDVELLQKTIAAMPVDVAKLHMKRCVDSGLWVPNAADLEGDKKEEDDSDDVAGGEEKTDDAKSESAAKEEPIYTGVSTEDVD
What is the function of this protein?
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.  Required for cytokinesis and chromosome segregation in mitosis and male meiosis.
What are the official names of this protein?
Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, Protein enhancer of sevenless 3B.
What is the protein family that this protein belongs to?
Belongs to the CDC37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLD5_HUMAN
Sequence: MGSAALEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKARVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKKNYV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space.
What are the official names of this protein?
Claudin-5, Transmembrane protein deleted in VCFS, TMDVCF.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: RECR_SERP5
Sequence: MQTSPLLETLMEALRCLPGVGPKSAQRMAFQLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQDICTICANPRRQQNGQICVVESPADIHAIEQTGQFAGRYFVLMGHLSPMDGIGPGDIGLDRLEQRLEKESVTEVILATNPTVEGDATANYIAEMCGQYGVVASRIAHGVPVGGELEMVDGTTLSHSLAGRHVIKF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: AROC_ACIBT
Sequence: MAGNSIGQLFRVTTCGESHGVGLMAIVDGVPPGLALTEEDLQKDLDRRKPGTSKFATQRKEPDQVEIISGVFEGKTTGTPIGLLIRNTDQKSKDYGNIAQTFRPGHADYTYTQKYGFRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGVLIRGHVTQIGNEVAEKLDWNEVPNNPFFCGDVDAVPRFEALVTSLREQGTSCGAKLEILAEKVPVGWGEPVFDRLDADIAHAMMSINAVKGVEIGDGFAVAGQFGHETRDELTSHGFLANHAGGILGGISSGQTIRVAIALKPTASITTPGKTINLNREDTDVLTKGRHDPCVGVRATPIAEAMLAIVLMDHFLRHRAQNADVVPPFAPIEP
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.