PharMolix/UniProtQA huggingface dataset:
Protein: RUTC_ECO57
Sequence: MPKSVIIPAGSSAPLAPFVPGTLADGVVYVSGTLAFDQHNNVLFADDPKAQTRHVLETIRKVIETAGGTMADVTFNSIFITDWKNYAAINETYAEFFPGDKPARFCIQCGLVKPDALVEIATIAHIAK
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: DNJC3_MOUSE
Sequence: MVAPGSVGSRLGAVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIALKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSEQEEKEAESQLVKADEMQRLRSQALDAFDGADYTAAITFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKSDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSVAEYTVRSKERICHCFSKDEKPVEAIRICSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYEAAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGGPFRFKFHFN
What is the function of this protein?
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress.  Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (PubMed:25329545).  Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity.  May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A.  May inhibit EIF2AK3/PERK activity (By similarity).
What are the official names of this protein?
DnaJ homolog subfamily C member 3, Interferon-induced, double-stranded RNA-activated protein kinase inhibitor, Protein kinase inhibitor of 58 kDa, Protein kinase inhibitor p58.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: TRPA_SOLM1
Sequence: MSQSILTTRIMEALAAGRKALIPFLPGGFPDKERFFDELAALDAGGADIIEIGVPFSDPVADGPVVEQASLDCLLNGTCLSWLFYELGKRKGQYRAGLVLMGYYNPFLQYGLEQLAADAADAGVSGFIVPDVPLEESGPLREALDKHGLDLIPLVGLNTSEERLAAYAQNARGYVYFVSVLGTTGMRESLPTEVKERLTAVRRIFNVPVALGFGIKSPEQLYAFGDLVDGVVFGSALIAHIKAGGTAAEFMARWRG
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: EFTU_HUMAN
Sequence: MTTMAAATLLRATPHFSGLAAGRTFLLQGLLRLLKAPALPLLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEGRDPELGLKSVQKLLDAVDTYIPVPARDLEKPFLLPVEAVYSVPGRGTVVTGTLERGILKKGDECELLGHSKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIKPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRIILPPEKELAMPGEDLKFNLILRQPMILEKGQRFTLRDGNRTIGTGLVTNTLAMTEEEKNIKWG
What is the function of this protein?
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.  Also plays a role in the regulation of autophagy and innate immunity.  Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway.  In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
What are the official names of this protein?
Elongation factor Tu, mitochondrial, EF-Tu, P43.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Protein: PSD_ECO8A
Sequence: MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMKEAQKPDTASYRTFNEFFVRPLRDEVRPIDTDPNVLVMPADGVISQLGKIEEDKILQAKGHNYSLEALLAGNYLMADLFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPAGENDGSVALLKGQEMGRFKLGSTVINLFAPGKVNLVEQLESLSVTKIGQPLAVSTETFVTPDAEPAPLPAEEIEAEHDASPLVDDKKDQV
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRPB_NITEC
Sequence: MKMYDLPDKRGHFGPYGGTFVAETLISALDELCKQYEYYRGDAEFQTEFFRELKHYVGRPSPIYHARRWSDHLGGAQILLKREDLNHTGAHKINNTVGQALLARRMGKSRIIAETGAGQHGVASATVAARYGMECVVYMGSEDVKRQATNVYRMKLLGATVIPVDSGSRTLKDALNEAMRDWVTNVGNTYYIIGTVAGPHPYPMMVRDFQAVIGNEARQQMQEEYGRQPDALIACVGGGSNAIGLFYPYIGEENVRMIGVEAAGKGIDTQKHAATLVTGRPGVLHGNRTYLIQDENGQIIETHSISAGLDYPGVGPEHAWLKDCGRAEYVAITDGEALAAFHALCRFEGIMPALESSHALAYAAKLAPTLRKDQLLLVNLSGRGDKDMATVAQQSGISL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: MGRB_SALTY
Sequence: MKKFRWVVLGIVVVVCLLLWAQVFNIMCDQDVQFFSGICAINKFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NDC80_KLULA
Sequence: MDELRDIRTTGPEDVLNSVDPYRYTSQIPNGKSNNGLNAKMNGNNTLTNMINRSIAKNMGQNASSGSMRRSMRQSLRNSLPRSSIGPQQQQQMNSTQNSTYHNTARDPRPLRDKNFQNLLQQEIFSYLTDQKFDVETNHPISLKSLKQPTQKDFIYMFKWLYLRLDPGYVFTKSLEHEVYSILRTIHYPYLATINKSQISAVGGSNWPKFVGMLHWLVIINKKLDECLEHLDVSINNQVTQDITVLNQPLKTAEEQEKKQEKYELMVERLFIDYITESYKSFLRLEDDYEPYLHDLELSFQRFVHIIETDIAQLTSTTEHLSVECESIVAKNYELKNIKEKNTGLEQEYKRLSHGVQITQAKSKEWPDKLKEIEDEIDKKKRDIRQVSLQIDELTSVLKRKNISGEEIEHKNKESDSISKSLDTVSSRLDQFTGLVRQQRLETESVYKNLQDTLKQYKSATEGLVIARKNLGDHIDESSIELVLPSDLMSEEMIGLTVEELIGDKKSFTDPIKKNLNKIAEDIKMRITNIQTENSKLQIKLEDLRNEITTKNEDLDQLEQQLSSIKSEYEEYRQESQSQLLSQNIKIEKLERKIQNARVESQQKISSIEREAEETRLKLEELKLLQNRERLELHNKVIQLIEYVSNFKINTQSSIEELQNATQKELQRLQTEV
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Probable kinetochore protein NDC80.
What is the protein family that this protein belongs to?
Belongs to the NDC80/HEC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Protein: Y274_HELPY
Sequence: MQDFDFSFNPKACEGCGAKCCVGESGYIFLNIQEMQQISAFLKLELEEFSQKYVKKVGYKFSLLEKDAKELGLACVFLDLETKKCQIYSVRPKQCQTFPFWEGVKTFSKEQKEAFCQSCPGITQKTKETKVR
What are the official names of this protein?
Uncharacterized protein HP_0274.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0661.
Protein: LPXC_NITSB
Sequence: MRQRTIERSVEVVGIGLHKGVPVTMRLEPLEENSGILFYRKDKNRYIELKPQNVVDTKMATVIGKDGVVISTIEHLMSAVYGYGIDNLLIILDNDEVPIMDGSAISYCMLLDEAGIMEQKSTKKVLRIKNEVEVRDGDKYVRLKPADTLSFDFTIHFDHPVIGKEHYHFEFSKKNFLEEIARARTFGFLHEVQYLRSIGLAQGGSLDNAIVLDEKKILNPDGLRFEDEFVRHKILDAIGDLSLLGMPVMGLYESFAGSHHLNHLLTVKLLEECSNYEIVEASTTTQEGYVIGAACAKE
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: LEU1_BACC3
Sequence: MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: NADA_CYAPA
Sequence: MSIFLKNKQFENITSQEQTKNNYKQLINDIQTLKKDLNAIILAHYYQEPDIQDVADFLGDSLGLAREAAKTNADIIVFAGVHFMAETAKILNPEKMVLLPDLNAGCSLADSCPPEIFSEFKKAHSDHLVISYINCSASIKAMSDIICTSANAVDIVNKIPLTQPILFAPDQNLGRYVISKTGRDLLLWPGSCIVHETFSEKKIFEFQSLYPTAEVIAHPECEPTILKHANYIGSTTSLLQYVKNSKKTTFIVITEPGIIHQMKKSCPEKQFLALPTVSGCACNECPHMRLNTLEKLYLAMKTRSPQIEIPESILLNAKKPIERMLEMSN
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: GRPE_THISH
Sequence: MSNEEQQQPNPAAQAPEGAVTEGAAPEFNPAVLLKQLEEAQAQAQEHFDKALRTQAEMENLRKRTARDVENARKFALEKFAGELLAVRDSLEMGLDAARGETDVEKIREGTELTLKMLAQVMEKFGVEAVDPQGQRFDPDRHQAMSMQPNAELEPNTVMAVLQKGYLLNDRLLRPAMVVVSKAPEGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNE_BARHE
Sequence: MKNAFLKTQLLPLRPLDESGSQWLKDITEQARKENLESLVSSLSNQGKQINFLNAVMTLSPFLREVLIANPSYLSPLLYVDIETRLSEIIEDITLIDKNKSIHETTLMAALRRKKREAHVLIALADLGGVFTYEISCAWLTRLGEAALGVALRFLLREAHDHGKINLSNREDPEKDCGLIILGMGKFGAGELNYSSDIDLIVFIDEMSPHVGNLSESIDVFSKMVRRLIRIIQERTAEGYVFRLDFRLRPDPGSTPLALPVRTALRYYEGRGQNWERAAMIKARPVAGDKSAGFNFLKELFPYVWRKYLDYAAIADIHSIKRQIHAYKNYDQISAYGHNIKLGRGGIREIEFFVQTQQLIAGGRFPQLRGRQTVAMLAELHRLGWISEKTRDSLVKSYAFLRNVEHRIQMLADEQTHILPIDVSQFTSVAYLMGYQETNSFICDLLKTLQVVEKHYAALFENEQELGLEIGNLVFTGEEDDPETLITLRRLGFERASDICRIMRTLHCGRYKSTQSAEARERLTELTPALLKAFGATKRADEVMLRFDSFLQGLPSGIQLFSLLQSNPSLLDMLVLIMGAAPRLAEIITHKPHVFDGMLDPTIFSELPTKTYLKNRLEYFLEGVISYEEILDHLRVFADEQRFLIGIRILNGAITGKKAGFAFTALADLIIAKTFATVQEEFSRLHGNIKGGRVGILGMGKLGSCELTAGSDVDLILLYEHDEDAEISDGGKPLYIFQYYTRLTQRLVAALSTLTSQGILYAVDLRLRPLGNKGPVAVSFEFFRKYYRKEAWIWEHLALTRARGIAGDLDFLQKLENEVYEIIAFSRNKKDVIKAVCEMHVLIGKGKPPENRWDLKRMPGGIMHLEFIAQFALITHVIVFQIGATTADILTQLPNSFLNQSFISDLHHAYGLYTNLSQIIRLCLNDALDLNNMPPGLSDLLLSSVGEPDLLRVEKLIEETGQLVYSIFKQVMKY
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: PPNP_CROS8
Sequence: MLQSNEYFSGKVKSIGFTSSSTGRASVGVMAEGEYTFSTAQPEEMTVVSGALHVLLPGETEWKTYEAGQVFHVPGHSEFHLQVAEPTSYLCRYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: RNPA_CHESB
Sequence: MSGRAQRQHPGRLTKRAEFLAVQRGLKLRGRLFLLELLARGDDDPPRVGITVTKKVGNAVERNRIRRRLREAVRVHAADDMATGTDYVIVGRREILDAPFGALKDELSRRIRGNKPARTG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: IF1C_CUCSA
Sequence: MKEQKRISESLITESLTNDMFWVCLENEDPILGYVSGRIRHSFIHILVKISVSCYDSTRTRRRIIYRLRNKDSND
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSRP_ECOSE
Sequence: MDNAVDRHVFYISDGTAITAEVLGHAVMSQFPVTISSITLPFVENESRARAVKDQIDAIYHQTGVRPLVFYSIVLPEIRAIILQSEGFCQDIVQALVAPLQQEMKLDPTPIAHRTHGLNPNNLNKYDARIAAIDYTLAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLVLPASLKPLQHKLFGLTIDPERLAAIREERRENSRYASLRQCRMEVAEVEALYRKNQIPWINSTNYSVEEIATKILDIMGLSRRMY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: NS1_HRSVB
Sequence: MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTNYMNQISDLLGLDLNS
What is the function of this protein?
Plays a major role in antagonizing the type I IFN-mediated antiviral response by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways.  Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3.  Also disrupts the association of IRF3 with CREBBP.  Interacts with host mitochondrial-associated membrane (MAM) MAVS and prevents the interaction with RIGI.  Interacts with TRIM25 to suppress TRIM25-mediated RIGI ubiquitination and thereby RIGI-MAVS interaction.  Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C.  The degradasome requires an intact mitochondrial MAVS.  Decreases the levels of host TRAF3 and IKBKE/IKK-epsilon.  As functions other than disruptions of the type I IFN-mediated antiviral signaling pathways, induces host SOCS1 and SOCS3 expression.  Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth.  Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication.  Suppresses proliferation and activation of host CD103+ CD8+ cytotoxic T-lymphocytes and Th17 helper T-lymphocytes.
What are the official names of this protein?
Non-structural protein 1, Non-structural protein 1C.
What is the protein family that this protein belongs to?
Belongs to the pneumovirus non-structural protein 1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host mitochondrion. Host nucleus. Note=Most NS1 resides in the mitochondria as a heteromer with NS2.
Protein: AROD_STRPZ
Sequence: MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFTLRTVQEGGNITLSSQEYVDIIKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNFEETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNYTRGFKTLNPEQEFATISMGKLGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: RSMA_BORGP
Sequence: MILSLLSMNINYNSITSIKQILKERKIAPRKLWGQNYLINESIRQKIIESLDIKENEKIWEIGPGLGAMTDILLKKTNLLTAFEIDLKYSEILNEKFGKLKNFKLIKGDFLKKYPNENKNIDKIFSNLPYNIASKVISKLIEENFLKEMVLTVQKELADRITAKTNSKNYSSFTVLVQSHFTAIKIIDIGENNFYPAPKVKSTTLKLIPKKNNIKDFKEFNKLIRTVFSGRRKKLKNTIINFIKNKAILEENFLKEYLGKRPENISVEEFIQISNNLNAYH
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUTX_EMENI
Sequence: MSPPSAKSMEEGRTPSVQYGYGDPKTLEGEIEEHTATKRGLSSRQLQLLAIGGCIGTGLFVGTSTVLTQTGPAPLLMSYIVMASIVWFVMNVLGEMTTYLPIRGVSVPYLIGRFTEPSIGFASGYNYWYSFAMLLASEVTASGLIIEYWNPPVSVGLWIAIVLVVILALNVFAVEWYGESEFWFAGLKILAIIGLIILGVVLFFGGGPNHDRLGFRYWQDPGAFNPYLVPGDTGKFLGFWTALIKSGFSFIFSPELITTAAGEVEAPRRNIPKATKRFIYRVFTFYILGSLVIGVTVAYNDPTLEAGVESGGSGAGASPFVVAIQNAGIGGLNHVVNAAILISAWSSGNAWCYAGSRTLYSLAGEGQAPKIFTRTNRTGVPYVAVLATWTIGLLSFLNLSSSGQTVFYWFTNITTVGGFINWVLIGIAYLRFRKALQFHGMLDMLPFKTPLQPYGTYYVMFIISILTLTNGYAVFFPGRFTASDFLVSYIVFAIFLALYAGHKIWYRTPWLTKVSEVDIFTGKDEIDRLCENDMERQPRNWLERVWWWIF
What is the function of this protein?
Required for high-affinity proline transport.
What are the official names of this protein?
Proline-specific permease, Proline transport protein.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KC1G2_MOUSE
Sequence: MDFDKKGGKGELEEGRRMSKTGTSRSNHGVRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTTEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCESFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGYVFDYEYDWAGKPLPTPIGTVHPDVPSQPPHRDKAQLHTKNQALNSTNGELNTDDPTAGHSNAPIAAPAEVEVADETKCCCFFKRRKRKSLQRHK
What is the function of this protein?
Serine/threonine-protein kinase.  Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  It can phosphorylate a large number of proteins.  Participates in Wnt signaling (By similarity).  Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3.  Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles.  Regulates fast synaptic transmission mediated by glutamate.  SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses.  Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.  Triggers PER1 proteasomal degradation probably through phosphorylation.
What are the official names of this protein?
Casein kinase I isoform gamma-2, CKI-gamma 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cytoplasm.
Protein: NDK_SHIB3
Sequence: MAIERTFSIIKPNAVAKNVIGNIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLEGENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSVESAAREIAYFFGEGEVCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.