PharMolix/UniProtQA huggingface dataset:
Protein: TXL1_SCHPO
Sequence: MSVIEIRSYQHWISTIPKSGYLAVDCYADWCGPCKAISPLFSQLASKYASPKFVFAKVNVDEQRQIASGLGVKAMPTFVFFENGKQIDMLTGANPQALKEKVALISSKATGTGALASSSSAPVKGFASLQGCIENPQLECLNQQDDHDLKSAFNSNPSSFLESDVDEQLMIYIPFLEVVKVHSIAITPVKGETSSAPKTIKLYINQPNNLSFEDAESFTPTQVIEDIVYEQDDQPTIIPLRFVKFQRVNSLVIFIYSNVGEEETTKISRLELFGEPVGDSSKGKLQKVEA
What is the function of this protein?
Has a role in cellular detoxification of alkyl hydroperoxide.
What are the official names of this protein?
Thioredoxin-like protein 1, Thioredoxin homolog 3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HIS2_SULIA
Sequence: MSNEIVDKLYKVILDRIEKRPTGSYTVEIVNKGKAYVARKVGEESVETIVASLAENKERFISEVADLIYHLLVLMALEGVTPDDIYRELERRRK
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTPS_HUMAN
Sequence: MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE
What is the function of this protein?
Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases.  Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
What are the official names of this protein?
6-pyruvoyl tetrahydrobiopterin synthase, PTP synthase, PTPS.
What is the protein family that this protein belongs to?
Belongs to the PTPS family.
Protein: TTCA_YERPN
Sequence: MLEKQSVNQKEQYNFNKLQKRLRRNVGQAIADFNMIEEGDRVMVCLSGGKDSYTMLDILQSLQKSAPINFSLIAVNLDQKQPGFPEDILPAYLDKQGVEYKIVEENTYGIVKEIIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKLKGMPPKLMSDDGKHIVIRPLAYCREKDIERFAVAREYPIIPCNLCGSQPNLQRQVIKDMLRDWDKQYPGRIETMFSAMQNVVPSHLNDHKLFDFKSITHDSDIIDGGDLAFDREALPLNPVGWQPEDDEDTEKRPPVRLDVLEIK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TZ72_HADIN
Sequence: MKLILLIAIFSALAVVNLGTPSADQVRYNYTELPNGEYCYTPRRRCTSADQCCRPYDTTAAFHGCGRIWPKDKREKVDRCYICNNEKTLCTSVMGK
What is the function of this protein?
Probable neurotoxin with ion channel impairing activity.
What are the official names of this protein?
U4-hexatoxin-Hi1a, U4-HXTX-Hi1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 27 (Jztx-72) family. ICK-72 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYK_BURP6
Sequence: MTEPTQPQAAVAADENQIVAERRDKLRALRDQGIAYPNDFQPTHHAAGLQTEYADADKEALDAKALDVAVAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFKKWDLGDIVAARGVLFRTNKGELSVKCTELRLLAKALRPLPDKFHGLADQETRYRQRYVDLIVTPETRATFRARTKAIASIRKFMSDADFMEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTERLIRQAAVDALGTATIRYQGRELDLAKPFHRLTITQAIQKYAPNYTDGQLSDDAFLRGELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIVDYPIEVSPLARESDTVAGITERFELFVTGREIANGFSELNDPEDQAARFRKQVEQKDAGDEEAMFFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFPHLRRED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLTF_SHIF8
Sequence: MKKLKINYLFIGILALLLAVALWPSIPWFGKADNRIAAIQARGELRVSTIHTPLTYNKINGKPFGLDYELAKQFADYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYNSERVKNYQPSPTYYSVSQQLVYKVGQYRPRTLGNLTAEQLTVAPGHVVVNDLQTLKETKFPELSWKVDDKKGSAELMEDVIEGKLDYTIADSVAISLFQRVHPELAVALDITDEQPVTWFSPLDGDNTLSAALLDFFNEMNEDGTLARIEEKYLGHGDDFDYVDTRTFLRAVDAVLPQLKPLFEKYAEEIDWRLLAAIAYQESHWDAQATSPTGVRGMMMLTKNTAQSLGITDRTDAEQSISGGVRYLQDMMSKVPESVPENERIWFALAAYNMGYAHMLDARALTAKTKGNPDSWADVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQATEAAMQLAQDYPAVSPTELGKEKFPFLSFLSQSSSNYLTHSPSLLFSRKGSEEKQN
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: OPSB_ARTOC
Sequence: MRGDSFIWSLTTAASLLYATVESLQVVKRDNPSIVGFDIERFQVAKPVHRDIIAKRASGKTVSQDLDNQTIRAHIDTGSSDLWVNTDDSQFCSSRRSPCREGGTFDSSSSSTYQLVSNDFNISYVDGSGASGDYVTDVIEVGGIQLKEFQFAIGHTSSSPLGVLGIGYEAGEALVSRFGDESYPNLPAALVKAGHIRSNAYSLWLNDLSASRGQILFGGVDTGKFEGKLQTVPVLHTSGGDYTSLVIALTSVGIRTASEGSLDTFPAQPVAVAMDSGSSLSYLPDALAAKIYNSIDAVFDPSNNLAFVPCSMVNDDRKLVFTFSSPQITVGMDELVIDLGPDANGNEATFRDGSKACVFGIAPAGRSISILGDTVLRSAYLVYDLDNNEISIAPTRFNSTVTNIMEIGTGKNSVPDATGVPNAVTSAPITQATGLSGIETGVPGARPTSRGAAPTMRPDVTFGVAAAGLAGAGILFAFM
What is the function of this protein?
Probable GPI-anchored aspartic-type endopeptidase which contributes to virulence.
What are the official names of this protein?
Probable aspartic-type endopeptidase OPSB.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: RS6_RALPJ
Sequence: MRHYEIVFIVHPDQSEQVPAMIERYKSTVTSQGGQVHRVEDWGRRQLAYMIQKLAKAHYVCLNIECGKETLAELEHAFKFNDAVLRHLIVQTKKAETAPSPMMKEVAREEAKKAAAQTEQAA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: YMFR_ECOLI
Sequence: MIMLILAPLVGVLGALLLAYGAWLIYPPAGFVVAGALCLFWSWLVARYLDRTQSSVGGGK
What are the official names of this protein?
Uncharacterized protein YmfR.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YIPF3_HUMAN
Sequence: MATTAAPAGGARNGAGPEWGGFEENIQGGGSAVIDMENMDDTSGSSFEDMGELHQRLREEEVDADAADAAAAEEEDGEFLGMKGFKGQLSRQVADQMWQAGKRQASRAFSLYANIDILRPYFDVEPAQVRSRLLESMIPIKMVNFPQKIAGELYGPLMLVFTLVAILLHGMKTSDTIIREGTLMGTAIGTCFGYWLGVSSFIYFLAYLCNAQITMLQMLALLGYGLFGHCIVLFITYNIHLHALFYLFWLLVGGLSTLRMVAVLVSRTVGPTQRLLLCGTLAALHMLFLLYLHFAYHKVVEGILDTLEGPNIPPIQRVPRDIPAMLPAARLPTTVLNATAKAVAVTLQSH
What is the function of this protein?
Involved in the maintenance of the Golgi structure.  May play a role in hematopoiesis.
What are the official names of this protein?
Protein YIPF3, Killer lineage protein 1, Natural killer cell-specific antigen KLIP1, YIP1 family member 3.
What is the protein family that this protein belongs to?
Belongs to the YIP1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Note=Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated.
Protein: LPXC_AROAE
Sequence: MIRQRTLKSIVKATGVGLHGGRKVQLVLRPAAPDTGVVFHRVDLDPPCDLPADPYSVCDTRMCSGLERNGAKVGTVEHLMSAVAGLGVDNLHVDVDAPELPILDGSAGPFVFLLQSAGIEEQKAPKRFLRVKKAVEYREDDKWVRLEPHDGFRLTFSIVFNHPAIDKTSTSVTVDFAEHSYVRDVARARTFGFMQDVDSMRAHGLALGGSLDNAIVMDEYRVLNSDGLRYVDEFVKHKVLDAIGDLYLCGHPLLAAYSAHKAGHALNNQILRVLLEDRSAWEIATFEQPGMTPAAVSHQFELAPAT
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: Y3426_COLP3
Sequence: MITKLPQVLSPIQVASIIQLIEHGSFNSGKDTAGWHAKAVKNNLQWQGETELNEQIQTGIQGALTQHPQFTGAAYAKSMMPFIISESTLGGGYGDHIDDALMVNETVLRTDISCTLFLTPPQDYEGGELVMNLSGMEMAFKLNAGDAIIYPSTTLHRVNPVTSGSRKVALTWIESHIPQASQREILFDLDCARKDIMEHHGKTDAFDRITKTHANLLRQWAMT
What are the official names of this protein?
PKHD-type hydroxylase CPS_3426.
Protein: C2D1B_HUMAN
Sequence: MMPGPRPRKGPQARGQGVAAAKQMGLFMEFGPEDMLLGMDEAEDDEDLEAELLALTGEAQTTGKKPAPKGQAPLPMAHIEKLAADCMRDVEEEEEEEGLEEDAELLTELQEVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQAGASQGLHALLEERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINEDEIPPPVALGKRPLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLDPDPRALLSSRQREYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAMPPAPEDLKPQQASQAPTAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRLNKYREAGIQARSGGDERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPGLESTMGVEEDAVAATLAAAEKLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPARPTVPSSQRLPEPRASSSKESPSPSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKWLEAQIIQARSGRPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQQEKCLLFSKQFMHQGNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQTVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLFKLNINRNHRGFKRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLENECEIREIVEVLDGRKPTGGKLEVKVRLREPLSGQDVQMVTENWLVLEPRGL
What is the function of this protein?
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.
What are the official names of this protein?
Coiled-coil and C2 domain-containing protein 1B, Five prime repressor element under dual repression-binding protein 2, FRE under dual repression-binding protein 2, Freud-2.
What is the protein family that this protein belongs to?
Belongs to the CC2D1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ALDH2_GEOSE
Sequence: MMSSIAAPKLKEKVEKFLSGKKKMYINGSFVESASGKTFDTPNPATGERLATVYEGDAEDIDRAVKAAREAFD
What are the official names of this protein?
Aldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: PHOSP_VSNJO
Sequence: MDSVDRLKTYLATYDNLDSALQDANESEERREDKYLQDLFIEDQGDKPTPSYYQEEESSDSDTDYNAEHLTMLSPDERIDKWEEDLPELEKIDDDIPVTFSDWTQPVMKENGGEKSLSLFPPVGLTKIQTEQWKKTIEAVCESSKYWNLSECQILNLEDSLTLKGRLMTPDCSSSVKSQNSVRRSEPLYSSHSPGPPLKVSESINLWDLKSTEVQLISKRAGVKDMTVKLTDFFGSEEEYYSVCPEGAPDLMGAIIMGLKYKKLFNQARMKYRL
What is the function of this protein?
Essential component of the RNA polymerase transcription and replication complex.  Binds the viral ribonucleocapsid and positions the L polymerase on the template.  May act as a chaperone for newly synthesized free N protein, so-called N(0).  Plays a role in virion assembly (By similarity).
What are the official names of this protein?
Phosphoprotein, P protein, Protein M1.
What is the protein family that this protein belongs to?
Belongs to the vesiculovirus protein P family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: NADA2_RHILO
Sequence: MSTIQPSAAFLYDRVQRLIPPIEWPAFAGDIDAILDLKRQRNAVILAHNYQTPEIFHCVADIVGDSLALARKAMSTEADVIVLAGVHFMAETAKLLNPQKTVLIPDLRAGCSLADSITAEDIRLLRQRYPGVPVVTYVNTSAEVKAESDICCTSGNAKAIVESLGVPRVIMLPDEYLAENIAAQTDVEIIAWKGHCEVHERFTPADIRQLRENHPGVIVLAHPECPPDVVAEADFSGSTAAMSDYVERQKPPRVVLLTECSMSDNVALQHPELEFIRPCNLCPHMKRITLANIRSALEQNRHVVTIEPGIAGRARLAVERMLAV
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase 2.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_BURM9
Sequence: MSIKSDKWIRRMAEEHKMIEPFVPDQVRAAEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: SEPF_CLONN
Sequence: MAKKMLNKVMDFLGLEEEIDEIEEMDNEAIVEGNEEIDNIFDSSNVRNQKGKVVSIHTTTSTKVLILKPMDYDAAIEICDNLKSRKIIVVNMTSLESKIAQRLLDFIAGASYALGGSLDEIDKGVYIVSPSNVEITNELKNELSTKGILNWTK
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: EFP_CLOBK
Sequence: MISAGDLRKGTTFEQDGQVYVVVEFLHVKPGKGAAFVRTKLKNAITGAVTETTFNPTAKLQEAVIERKEMQYLYTDGELYYFMDQETFEQIPLNYDKVEEAIKFLKENMFATIKFFKGEAFSVEAPNFVELLISHTEPGAKGNTTSNVMKPATLETGATIQVPLFVNEGETIRVDTRTGEYMERV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEP3_HHV6U
Sequence: MGAKCCKPVSCGMCKKTENTLIDYKGNPILLANEFTVLTDTESEEEGMADLEKPLLEKVVAKCDTEAEKKLPCKSKK
What is the function of this protein?
Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes.  Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.
What are the official names of this protein?
Cytoplasmic envelopment protein 3.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.
What are the subcellular locations of this protein?
Virion tegument. Virion membrane; Lipid-anchor. Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Note=Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: HSLU_CHRVO
Sequence: MTQMTPQEIVHELDQHIIGQHKAKRAVAIALRNRWRRQQVAEPLRSEITPKNILMIGPTGVGKTEIARRLAKLSGAPFIKVEATKFTEVGYVGRDVDTIIRDLVDVAIKDTREAAIKRNRTRAEDAAEERILDVLLPQPRKQPSGFFAEEPAVEEKHEDGATRQKFRKMLREGKFDDKEIELEIAAPAAQMNVMAPPGMEDFASQLQGMFQGLGAGKKQTAKMKVADAFKQLIDEEAAKLVNEEELKAEALKNVEQNGIVFIDEIDKVTSRGEGHSGADVSRAGVQRDLLPLVEGTTVSTKYGMVKTDHILFIASGAFQLSKPSDLIPELQGRLPIRVELSSLSVDDFKAILTSTNACLTRQYQALLATEGVELAFEDSGIQRLAEIAWQVNEKTENIGARRLYTVMEKLLEEVAFDAKSGACRIDGAYVDGKLGEVAEREDLARYVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFGM_DICDI
Sequence: MTSFLTSRFGGLALRNVMNNKNGINSFGLRCFSTNSVSGLRNIGISAHIDSGKTTLTERILYYTGRIKEIHEVRGKDGVGAKMDSMDLEREKGITIQSAATYCKWGENHINIIDTPGHVDFTIEVERALRVLDGAVLVMCGVSGVQSQTITVDRQMRRYNVPRVVFINKLDRTGANPWNVIEQLRKKLNLNAIALQVPIGKESNLEGVIDLVTEKAMIFGEKGTAPIIEEIPSNFVEFVKEKKMELVETIANVDDELGEWMIENDFPNNMPDEKTLTAAIRRTTIARKVVPVMMGSAFKNTGVQPLLDGVIKYLPSPNEKKIIALDTSVKDKETEVELESDPKKPFVGLAFKLEEGRFGQLTYMRVYQGTLKRGDTIKNVNLGKTIKVPRLVKMHASEMEEVSEVGPGEICAMFGVDCYSGNTFTHQNCSYTMTSMHVPEPVMSLSIQPKSKDGQANFSKALSKFQKEDPTFRVKSDQESGQIIISGMGELHLEIYVERMKREYNVETVTGKPLVAYRETIQQRGDYNFTHRKQSGGQGQYAKMIGFAEQSENGMENEFVNDVIGTAIPPTFIEAIKKGFKDCIEKGPLIGHPVVGVKFVVSDGNTHSVDSSELAFRIATAGAFKEAFEDGEPTILEPIMKVEISLPQEFQGTVISGVNRRKGAIVNTTTQGESLTFECEVPLNNMFGYSTELRSMTQGKGEFSMEYLKHTNVSRELYNQLLEEYKKKRTEENK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TBCD_CHICK
Sequence: MAVGETDGAGSEESGSREADVISRGNILESFTESQEVRALLGNLRTVYGDPVAQEVIVEKFIVIMDKYQEQPHLLDRHLEWMMNMLLDIIRDSGSPPVLFHLAFKFLYIITKVRGYKLFLRLFPHEVTDLQPVLDMIVDQNPKDCETWETRYMLLLWLSMICLIPFDLARFDGNILSEEGHTRMPTMDRILEIAKCYLVVSDKARDAAAVLVSKFIVRPDVRQKRMADFLDWTLSMLSKSSFQSMEGTVVMNGMLQALAQLFKHGKREDCLPYAATVLECLDNCKLSESNQMVLRKLGMKLVQRLGLTFVKPKVAKWRYQRGCRSLAANLQAQSSVMQSQKITVAANEAEDDEEYDIPGEIENVVEQLLVGLKDKDTIVRWSAAKGIGRITGRLPKELADDVVGSLLDCFSFQETDNAWHGGCLALAELGRRGLLLPSRISDVVPVILKALTYDEKRGSCSVGSNLRDAACYLSWAFARAYDPSELIPFINQISSALVIAAVFDRDVNCRRAASAAFQENVGRQGTFPHGIDILTAADYFAVGNRVNCYLTISVYIAGFPEYTQPMIDHLVNMKINHWDSVIRELSTKALHNLTPRAPEYMANVVLPRLLPLSVGTDLHTRHGAILACAEITHALCKLAEENNRSITYYFNGKSLEGLKQIHQELCSRQLYRGLGGELMRPAVCTLIEKLSLSKMPFKGDPIIEGWQWLINDSLRSLPLASCAARQHVKESAVSALSALCNEYYINENGEADPALQGELVTQYISELQSTEQMIRCGFSLALGALPRFLLKGRLQQVLEGLRKVTLITPRDVSFAESRRDALIAIAEICQTVGVKGEGSQEEYICKDNVAQIYATLLNCVTDYTTDSRGDVGGWVREAAMTSLMKVTLLLVQNEAELINANICKQIMCWLAQQSAEKIDKFRAHAGSVFLTLLHFDSPPVPHIPHREELERIFPRSEAETLNWNAASEAFPRITQLLALPAYQYYVLLGLSVSVGGLTETTGVCAPPDNAGPNAGKRLF
What is the function of this protein?
Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly.  Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB).  Its ability to interact with beta tubulin is regulated via its interaction with ARL2.  Acts as a GTPase-activating protein (GAP) for ARL2.  Induces microtubule disruption in absence of ARL2.  Increases degradation of beta tubulin, when overexpressed in polarized cells.  Promotes epithelial cell detachment, a process antagonized by ARL2.  Induces tight adherens and tight junctions disassembly at the lateral cell membrane.  Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis.  Involved in neuron morphogenesis.
What are the official names of this protein?
Tubulin-specific chaperone D, Beta-tubulin cofactor D, Tubulin-folding cofactor D.
What is the protein family that this protein belongs to?
Belongs to the TBCD family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Lateral cell membrane. Cytoplasm. Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized in cell-cell contacts.
Protein: HTPG_DESVH
Sequence: MATAPASHAFRTEVRKMLHIITHSLYTNREIFLRELVSNASDALDKLRFIRSRGDAVVAPDLAPGIDISVDKEARILTIADTGVGMTRQELMDNLGTIARSGSEQFVADLAAAENAKDADAASIIGRFGVGFYAVFMVADRVEVTSRSYIEGEAAHTWTSDGLGEFTVEEATGDIPQRGTVIKAHLREDAAEFLEKYRIEGILRKHSQFISFPIRVDGEQVNTTPALWREPKFSITDEQYADFYKHLTFDTEAPLRTLHVSVDAPVQFTGLVFVPPHGQEVFSMGRDRWGLDLYVRRVLIQRENKDLLPEYLGFLKGIVDTEDLPLNISRETLQENVVVRKIGQTLTKQVLADLARLAADDAEAYATFWRQHGKVFKLGYSDYANREKFAPLLRFNSSHHDDAQGLTSLDDYISRAREGQKEIWYIAAPGREAARLDPRVEVFRRKGLEVLYLLEPIDEFVLETLDSYSDFSFKAVEHADGEKLAQFEDTGPARDVTPLTEDEDAAFARLIERMKALLGDAVEDVRISHRLADSPACLVQPGGASTSSMDRLLRVLHKDESVPRKVFEVNRDHPILRNLLKVFTSDASDPLVEDTTRQLFATSLMLDGYLKDPHELAAMMHRLMEKSGDWYKAVRGL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_PYRCJ
Sequence: MKALIDAGVVKFGRFVLSSGIESPFYVDLRRALGHPDLVKWVVSGYLSALSRLKFDVLLGVATGGIPYASILGYLLQKPFGYVRAGAKGYGTMQAVEGADVAGLAAVVVDDVLTTGNSLINAIKAVREAGGEVVGALVFLDREQCGSQNVRRETGVEVFSVYKMRELLETLKPYIGEGHYRAAVEYLAKWSC
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: BOA12_BOTFB
Sequence: MTSHRSESKATIKVRPPPSFIGGVQDKSWTPTPENWLYGAWYMTHTSQQYYWERTKNFVIQYEPVMNGVWPCTNQELVSLTPLNQPERIYTAFGIDSPIAGLDDAWLCQCTGHLSHISDHVAFLAWGADLQNVDWVVLYSTPLPGATVGLPAQVAIMSRERFGPDNTMVEAIKEALCAAGNSELTKLVDNLRPLLQEDLGSGRPTCEYHVVQNVDSLTRF
What is the function of this protein?
Part of the gene cluster B that mediates the biosynthesis of botcinic acid and its botcinin derivatives, acetate-derived polyketides that contribute to virulence when combined with the sesquiterpene botrydial (PubMed:21722295).  Botcinic acid and its derivatives have been shown to induce chlorosis and necrosis during host plant infection, but also have antifungal activities (PubMed:21722295).  Two polyketide synthases, BOA6 and BOA9, are involved in the biosynthesis of botcinins.  BOA6 mediates the formation of the per-methylated tetraketide core by condensation of four units of malonyl-CoA with one unit of acetyl-CoA, which would be methylated in activated methylene groups to yield a bicyclic acid intermediate that could then either be converted to botrylactone derivatives or lose the starter acetate unit through a retro-Claisen type C-C bond cleavage to yield botcinin derivatives (PubMed:23203902).  The second polyketide synthase, BOA9, is probably required for the biosynthesis of the tetraketide side chain of botcinins (Probable).  The methyltransferase (MT) domain within BOA6 is probably responsible for the incorporation of four methyl groups (Probable).  The trans-enoyl reductase BOA5 might take over the enoyl reductase function of BOA6 that misses an ER domain (Probable).  The monooxygenases BOA2, BOA3 and BOA4 might be involved in further hydroxylations at C4, C5 and C8, whereas BOA7, close to BOA9, could potentially be involved in the hydroxylation at C4 in the side chain of botcinins (Probable).
What are the official names of this protein?
Botcinic acid biosynthesis cluster B protein 12.