Protein: CTVA_ASPTN
Sequence: MAHMEPIAIVGTACRFAGSSSSPSKLWELLQNPRDVASEPPADRFNIDAFYDPEGSNPMATNARQGVSCAAPQYGSVGVARNNLANRISYFFDWQGPSMSIDTACSASMVALYEAVSALTRHDCNLAAALGANLMLSPQMFIAASNLQMLSPTSRSRMWDAQADGYARGEGVASVLLKRLSDAVADGDPIECVIRAVGVNHDGRSMGFTMPSSDAQVQLIRSTYAKAGLDPRSAEDRPQYVEAHGTGTLAGDPQEASALHQAFFSSSDEDTVLHVGSIKTVVGHAEGTAGLAGLIKASQCIQHGIIPPNLLFNRLNPALEPYARQLRVPVDVVPWPPLSPGVPRRVSVNSFGFGGTNAHVILESYEPAEGLIKVDCNQNAVLPFVFSAESDFSLGSVLEQYSRYLSRNPDVEVHDLAWTLLERRSALMHRVGFWAPDIAHLKRSIQDELAVRKGGAPSTLICRPHGKTRKHILGVFTGQGAQWAQMGLELITTSNTARGWLDELQQSLDALPEPYRPGFSLFQELAADSATSRLSEALLSQTLCTAMQVIWVKMLWALNIHFDAVVGHSSGEIAAGFAAGFLTAEDAIRIAYLRGVFCSAPGSSGEGAMLAAGLSMDEATALCEDVSSSEGRINVAASNSPESVTVSGDRDAILRAEQLLKDRGIFVRLLRVSTAYHSHHMQACSQPYQDALRGCNIQIQTPMSTTTWYSSVYAGRPMEEGSVTETLGTGEYWAENLVSPVLFSQALSAAMSATNPSLIVEVGPHPALKGPALQTLSGITPAEIPYIGVSVRNNSAIESMATAIGAFWAHLGPQAINPRGYLALFQPNTKPSVVRGLPLYPFDHRQEHGYQTRKANGWLYRRNTPHPLLGSLSEDLGEGELRWNHYLSPRRIRWLDGHRVQGQIVVPATAYIVMALEAALALAVVKEKSLHLIRIDDLIIGQAISFQDERDEVETLFHLPPMLENRDDNTAVGRFRCQMAASGGHIKTCAEGILTVTWGSPQDDVLPCPVFPSPAGLADVTDMEEYYASLRTLGYEYTGVFQGIHSLSRKMGIATGQVYNPALTGFLIHPAVLDTGLQGLLAAAGEGQLTTLHVPTRIDTVSVNPAVCSIDSLSFEAAVTRTGADGIVGDVELYTAANGPGAVFFEGVHVSSLVPPSAADDPSVFWVQHWTPLVLDVNRSESRLSPEWMTVLEGYERRAFLALKDILQEVTPELRATFDWHRESVVSWIEHIMEETRMGQRASCKPEWLGQNLENLGHIWGRPDASIEDRMMYRVYQNLLPFLRGEAKMLDALRQDELLTQFYRDEHELRDVNRRLGQLVGDLAVRFPRMKLLEVGAGTGSATREVLKHVSRAYHSYTFTDISVGFFEDMLETLPEHADRLIFQKLDVGQDPLEQGFTENAYDVIIAANVLHATPALHETLRNVRRLLKPGGYLIALEITNIDAIRIGYLMCAFDGWWLGREDGRPWGPVVSASQWDSLLRETGFGGIDSITDRAADELTMYSVFAAQAVDDQITRIREPLTPLPPQPPFCRGVIIGGSPNLVTGVRAIIHPFFSDVEHVSAIENLTEGAPAVVLMVADLSDTPCFQSLTESRLAGLKALVKMAEKTLWVTMGSEAENPFLCLSKGFLTSMNYEHPNVFQYLNIIDPADVQPVVLSEHLLRLAHTTQNNDFTLTSCVHSTELELRLYPGGILKFPRINASNVLNRRYAAARRPVTSPVTDMQESVVVLGQGPDGKLQLLLGEERLLGDRTGVTINVRYSTNRAVRINGAGYLVLVLGQDKVTKTRLVALAGQSASVISTSCYWEIPADISEEQEAAYLYATATALLAASLIQSNGTTILVHGADAILRHAIAIEAASRVVQPIFTTTSPSAASSTGFGKSILVHQNESRRQLAHLLPRYFTAAVNFDSNDHRLFDRMMAIGHQSGVTQEHLLTTLTAVLPRPSASSLPAHPQAVIDALRKAALTAYQLTVQSTAPGHIATSIADIQSCSQELAVADWTPPCGSVPVHLQPASQLVRLSAQKTYLLVGMTGALGQSITQWLIARGARNIVLTSRNPSVDPAWILEMQSTTGARVLVTSMDVTSRASILAVAHALKAGWPPLGGVVNGAMVLWDQLFVDAPLSVLTGQLAPKVQGSLLLDEIFGQEPGLDFFILFGSAIATIGNLGQSAYTAASNFMVALAARRRARGLVASVLQPAQVAGTMGYLRDKDDSFWARMFDMIGRHLVSEPDLHELFAHAILSGRGPPSDVGFGPGEGECVIGGLSVQDPAVYPNILWFRTPKVWPFIHYHHEGTGPSSAATGSVPLVEQLKCATSLAQVGEVVEAGVAAKLHHRLHLPGEVGSGNVTGDTRLTELGVDSLIAVDLRRWFAQELEVDIPVLQMLSGCSVKELAAAATALLQPKFYPGVVGDSDVGSEKDGSSDSRGDTSSSSYQVITPEESD
What is the function of this protein?
Highly reducing polyketide synthase (HR-PKS); part of the gene cluster that mediates the biosynthesis of citreoviridin, an inhibitor of the of F1-ATPase beta-subunit (PubMed:26954888).  The HR-PKS ctvA accepts acetyl-CoA as the starter unit and catalyzes eight iterations of malonyl-CoA extension and four iterations of SAM-dependent methylation at C4, C12, C14, and C16 (PubMed:26954888).  The KR and DH domains selectively act on the first six iterations to generate the hexaene chain (PubMed:26954888).  In the last three iterations, the KR and DH domains terminate their functions to yield a beta,delta-diketo ester moiety, which then undergoes intramolecular cyclization to yield an alpha-pyrone intermediate (PubMed:26954888).  Subsequently, ctvB methylates the alpha-pyrone hydroxyl group to generate citreomontanin (PubMed:26954888).  In order to form the tetrahydrofuran ring with the correct stereochemistry, the terminal alkenes of citreomontanin need to undergo isomerization to yield a (17Z)-hexaene, a step that could be catalyzed by ctvC (PubMed:26954888).  The (17Z)-hexaene then undergoes bisepoxidation by ctvC to form a (17R,16R,15S,14R)-bisepoxide moiety (PubMed:26954888).  Lastly, ctvD acts as a regioselective hydrolase to form the tetrahydrofuran ring with the substituents in the correct absolute configuration, completing the biosynthesis of citreoviridin (PubMed:26954888).
What are the official names of this protein?
Highly reducing polyketide synthase ctvA, HR-PKS ctvA, Citreoviridin biosynthesis protein A.