PharMolix/UniProtQA huggingface dataset:
Protein: NADK_CORGL
Sequence: MAAKLLDDAGIDVRVLINDADDPIAEHSVLGRFTHVRHAADAADGAELVLVLGGDGTFLRAADMAHAVDLPVLGINLGHVGFLAEWESDSLEEALKRVIDRDYRIEDRMTLTVVVLDGGGEEIGRGWALNEVSIENLNRRGVLDATLEVDARPVASFGCDGVLISTPTGSTAYAFSAGGPVLWPELDAILVVPNNAHALFTKPLVVSPKSTVAVESNSDTSAAMAVMDGFRPIPMPPGSRVEVTRGERPVRWVRLDSSPFTDRLVSKLRLPVTGWRGPQKQAENKDPRSAG
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24E_METKA
Sequence: MPDVRRCDFCGRIIEPGTGKMFVKNDGTILWFCSSKCERNMLKLGRDPKKVRWTEKHREFMAEQRGEL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: GLMS_METKA
Sequence: MCGIVGYTGERDAAPIIVDSLVRLEYRGYDSAGVATIHEGRLYLEKDAGKLTEGGEPTKLQRSLRKLPGKIGIGHTRWATHGDPNRRNAHPHTDCRDEIAVVHNGIIENFMQLREELEDKGHRFDSETDTEVVPHLIEQGMKEGKSFFEAFVEAVRRLEGSYAIAAICTREPDVILAARKESPLVVGLGDDGNFLASDIPAILPETNRVIPIDDGEIVVVKRDEVRILDAETLEDVTEEKEVQIVEEDPHTLERRGYPHFMLKEIHEQPEAVRNTLRIERENLMEMAEELVGGDYTKLYIVACGTSYHAGLGAKYATELLAKFPVDVVIASEFRYVTKELVDENTLVLAISQSGETADTLAAVREANARGATTIALTNVVGSTITREVDHVMYTHAGFEKAVAATKTYTAQLAAMYTLAVELARHFGEITNKEAEEYHAELNKVPEMLEEVLSWEREREIAVMGGRYKERPNWFFIGRGPGYPTAMEGALKLKEITYQHAEAYPAGELKHGPLALIEEGVPVVAVAQPGGVYEKMLANIEEVKARGATVITVADEKDEAVEEHSDHVIRVPSISEVFSPIVYTVPLQLLAYYMSVARGIDPDYPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NODD1_BRASN
Sequence: MRFKGLDLNLLVALDALMTERNLTAAARKIHLSQPAMSAAVARLRTYFGDELFTMRGRELVPTPRAEGLAAPIREALLHIQLSIISRDAFDPAESSRRFRIILSDFMTIVFFRRIIDRVAREAPAVRFELLPFSDEHDELLRRGEVDFLVFPELFMSSAHPKATLFEETLVCVGCRTNKQLSRQLTVEKYMSMGHVAAKFGRALRPNIEEWFLLEHGLKRRIEVVVQGFGMIPPVLVDTVRIGTMPLRLAKHFEKQMLLKIVEPPLPLPSFTEAVQWPAAKNTDPASIWMRRIILQEAANMASAHEAARHRRHC
What is the function of this protein?
NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins.  NodD is also a negative regulator of its own expression.  Binds flavonoids as inducers.
What are the official names of this protein?
Nodulation protein D 1.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: FYV7_DEBHA
Sequence: MGDKKQFRGKNPYTDRREFKSKEIKKSLVHRARLRKNYFKLLEKEGINHEPEQNGDESAESQNKSEEFKRSHIPDSRNQPSKRPMNFAERAKIAKERKEHSRQAKLKSIQDRRETIEKKSKERERRKDNLSKKTKSGQPLMGPRINNLLDKIKKDIE
What is the function of this protein?
Involved in the processing of the 20S pre-rRNA.
What are the official names of this protein?
rRNA-processing protein FYV7.
What is the protein family that this protein belongs to?
Belongs to the FYV7 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL5_THEPA
Sequence: MTFLRVVKNKAYFRRFQVKFRRRREGKTDYYARRRLVAQDKNKYDSPKYRLVVRLTNKRVICQIVSSTLVGDKVHASADSSELVHYGVKVGLTNYAAAYCTGLLLARRLLTKLKLDSQFVGKVEADGELYHVEEEDNERRPFKALLDVGIKNVTTGNRVFGALKGACDGGLHVPHSEKRFPGYSVDDENNGSYDAQAHRDRIFGTHVANYMEYLKEEDPEKYKRQFSAYLKLGLDSESLEDMYAKAHENIRKNPVLPTKPKRKLKHVREGSKVLTSKGSYVRNVKISKAQRRERVKQKISLLVNES
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EMC6_YEAST
Sequence: MSSNEEVFTQINATANVVDNKKRLLFVQDSSALVLGLVAGFLQIESVHGFIWFLILYNLINVIYIVWICQLQPGKFYQSPLHDIFFESFFREITGFVMAWTFGYALIG
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151).  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151).  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151).  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
What are the official names of this protein?
ER membrane protein complex subunit 6.
What is the protein family that this protein belongs to?
Belongs to the EMC6 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CYVI_VIOBI
Sequence: AAFALPAFASFEKDVITPAALEAVLNRKAPLSNIMMENDAILNVIANVKTVISNPVLEEALLKTNHGVNGIPCGESCVWIPCLTSTVGCSCKSKVCYRNSLDN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide vibi-I, Vbc2.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: ARNA_ECO24
Sequence: MKTVVFAYHDMGCLGIEALLAAGYEISAIFTHTDNPGEKAFYGSVARLAAERGIPVYAPDDVNHPLWVERIAQLSPDVIFSFYYRHLICDEILQLAPAGAFNLHGSLLPKYRGRAPLNWVLVNGETETGVTLHRMVKRADAGAIVAQLRIAIAPDDIAITLHHKLCHAARQLLEQTLPAIKHGNILEIAQRENEATCFGRRTPDDSFLEWHKPASVLHNMVRAVADPWPGAFSYVGNQKFTVWSSRVHPHASKAQPGSVISVAPLLIACGDGALEIVTGQAGDGITMQGSQLAQTLGLVQGSRLNSQPACTARRRTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIDGGKQKRCFTDIRDGIEALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHHFPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNAHRCLDWEPKIDMQETIDETLDFFLRTVDLTDKPS
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: MSCL_BACCN
Sequence: MWNEFKKFALKGNVMDLAVGVVIGGAFGKIVSSLVSDVIMPLVGLLLGGVNFTGLSFTFGKAVVKYGAFIQTVVDFLIIAFSIFLFIKLFNKLTFKKEEEKKEEVPEPTKEEVLLGEIRDLLKQQNASKDRA
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYGB_DESAL
Sequence: MQPLLLEIGSEEIPAGYIVPALEALAQALDAKLESARIAHSKPKVYGTPRRLAVILDEVAEKQESVTTEMVGPPKSVAFDGEGKPKVPAVKFAEKAGVAVEELTFQETEKGVYLCAKIQDEGKETLGILQEMLPEIISHIPFPKSMRWAALPGTFARPVFSILALLGDQVIPFEWNGVTTGRQTRGHYFMAPEAIDIQTPSEYVNALEKAKVIADIPTRRKMVKEGVDAIAKELGGDAIEDEELVDIVANLVEFPAPVGGKFETGFLEVPDKVLITAMREHQKYFAIQDKDGKLMPCFVAVNNTQCKDPQLVATGHERVLRARLSDAKFFWDVDKKQSMEDWVKRLDRVLFQKKLGSVGEKVARVEEMAKFLAAAPEINGDPDKAQKAAHFCKADLVSGLVIEFTKLQGVMGKAYASLAGMDAETASALEEHYLPAYSGGPLPRTKTGDAVAMADKMDSLCGCFAVGLIPSGNRDPYALRRQGIGVIRILQEKGYSLSLSAIVDKGLTLVKDKADQNLAETRDKIISFLADRMAHMLAEQGFSKDVIQAAVAISCDDIPYLWKRVAAVEKLKTLPDYEALAQTFKRVANIIKQAAEKGTLSDQEVNPALFEKDCEKDLLEAFTAMEAKVSGLGVDEALLEVAKLRPAVDAFFDDVMVMAEDMKVRENRLALLAGIAGLFGRFADFSRISA
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_SALNS
Sequence: MTRLTLALDVMGGDFGPSVTVPAALQALNANSQLTLLLVGNPDIITPLLAKADFEQRSRLQIIPAQSVIASDARPSQAIRASRGTSMRVALELVKEGRAEACVSAGNTGALMGLAKLLLKPLEGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLVQFAVMGAVLAEEVVGIKNPRVALLNIGEEETKGLDSIREASLMLKTVPTINYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKRSWWLLLLKRWLQKSLTRRFSHLNPDQYNGACLLGLRGTVIKSHGAANQRAFAVAIEQAVQAVQRQVPQRIAARLESVYPAGFEPLDDGKGVNLRAHR
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: DTC_ARATH
Sequence: MAEEKKAPISVWTTVKPFVNGGASGMLATCVIQPIDMIKVRIQLGQGSAASITTNMLKNEGVGAFYKGLSAGLLRQATYTTARLGSFKLLTAKAIESNDGKPLPLYQKALCGLTAGAIGACVGSPADLALIRMQADNTLPLAQRRNYTNAFHALTRISADEGVLALWKGCGPTVVRAMALNMGMLASYDQSAEYMRDNLGFGEMSTVVGASAVSGFCAAACSLPFDFVKTQIQKMQPDAQGKYPYTGSLDCAMKTLKEGGPLKFYSGFPVYCVRIAPHVMMTWIFLNQITKFQKKIGM
What is the function of this protein?
Catalyzes the transport of dicarboxylates, such as oxoglutarate, oxaloacetate, malate, and succinate, and of tricarboxylates, such as citrate, isocitrate, cis-aconitate, and trans-aconitate by a counter-exchange mechanism across the inner mitochondrial membrane.  Substrate preference in reconstituted proteoliposomes is oxaloacetate > malonate > malate > maleate > succinate > oxoglutarate > citrate > trans-aconitate > cis-aconitate > sulfate > isocitrate.  May be important for plant metabolic functions requiring organic acid flux to or from the mitochondria, such as nitrogen assimilation, export of reducing equivalents from the mitochondria, and fatty acid elongation.
What are the official names of this protein?
Mitochondrial dicarboxylate/tricarboxylate transporter DTC, Dicarboxylate/tricarboxylate carrier.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS27_HUMAN
Sequence: MPLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH
What is the function of this protein?
Component of the small ribosomal subunit (PubMed:8706699, PubMed:23636399).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).  Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
What are the official names of this protein?
40S ribosomal protein S27, Metallopan-stimulin 1, MPS-1, Small ribosomal subunit protein eS27.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: LT_POVMA
Sequence: MDRVLSRADKERLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMNLGGTGFQGSPPRTAERGTEESGHSPLHDDYWSFSYGSKYFTREWNDFFRKWDPSYQSPPKTAESSEQPDLFCYEEPLLSPNPSSPTDTPAHTAGRRRNPCVAEPDDSISPDPPRTPVSRKRPRPAGATGGGGGGVHANGGSVFGHPTGGTSTPAHPPPYHSQGGSESMGGSDSSGFAEGSFRSDPRCESENESYSQSCSQSSFNATPPKKAREDPAPSDFPSSLTGYLSHAIYSNKTFPAFLVYSTKEKCKQLYDTIGKFRPEFKCLVHYEEGGMLFFLTMTKHRVSAVKNYCSKLCRSFLMCKAVTKPMECYQVVTAAPFQLITENKPGLHQFEFTDEPEEQKAVDWIMVADFALENNLDDPLLIMGYYLDFAKEVPSCIKCSKEETRLQIHWKNHRKHAENADLFLNCKAQKTICQQAAASLASRRLKLVECTRSQLLKERLQQSLLRLKELGSSDALLYLAGVAWYQCLLEDFPQTLFKMLKLLTENVPKRRNILFRGPVNSGKTGLAAALISLLGGKSLNINCPADKLAFELGVAQDQFVVCFEDVKGQIALNKQLQPGMGVANLDNLRTTWNGSVKVNLEKKHSNKRSQLFPPCVCTMNEYLLPQTVWARFHMVLDFTCKPHLAQSLEKCEFLQRERIIQSGDTLALLLIWNFTSDVFDPDIQGLVKEVRDQFASECSYSLFCDILCNVQEGDDPLKDICDIAEYTVY
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription.
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.
Protein: Y1892_XANOP
Sequence: MRGRDEDTGEFRGASRSQQRREALEIFDLGEKLVALTPAQLAKLPVPESLIPHIEESKRITSHIAHKRQLAFLAKHMRREDDETLAAIRDALDANSDTARREVAAIHRVERWRERLLADGDAALAELLEAYPAADRQQLRQLVRNAIHERAKNKPPRAYRELFQVLRDLSQEQGLESGDSGLEDGESALEDDE
What are the official names of this protein?
UPF0307 protein PXO_01892.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: SUIS_RABIT
Sequence: MAKRKFSGLEITLIVLFVIVFIIAIALIAVLATKTPAVEEVNPSSSTPTTTSTTTSTSGSVSCPSELNEVVNERINCIPEQSPTQAICAQRNCCWRPWNNSDIPWCFFVDNHGYNVEGMTTTSTGLEARLNRKSTPTLFGNDINNVLLTTESQTANRLRFKLTDPNNKRYEVPHQFVTEFAGPAATETLYDVQVTENPFSIKVIRKSNNRILFDSSIGPLVYSDQYLQISTRLPSEYMYGFGEHVHKRFRHDLYWKTWPIFTRDQHTDDNNNNLYGHQTFFMCIEDTTGKSFGVFLMNSNAMEIFIQPTPIVTYRVIGGILDFYIFLGDTPEQVVQQYQELIGRPAMPAYWSLGFQLSRWNYNSLDVVKEVVRRNREALIPFDTQVSDIDYMEDKKDFTYDRVAYNGLPDFVQDLHDHGQKYVIILDPAISINRRASGEAYESYDRGNAQNVWVNESDGTTPIVGEVWPGDTVYPDFTSPNCIEWWANECNIFHQEVNYDGLWIDMNEVSSFVQGSNKGCNDNTLNYPPYIPDIVDKLMYSKTLCMDSVQYWGKQYDVHSLYGYSMAIATERAVERVFPNKRSFILTRSTFAGSGRHAAHWLGDNTATWEQMEWSITGMLEFGLFGMPLVGADICGFLAETTEELCRRWMQLGAFYPFSRNHNADGFEHQDPAFFGQDSLLVKSSRHYLNIRYTLLPFLYTLFYKAHAFGETVARPVLHEFYEDTNSWVEDREFLWGPALLITPVLTQGAETVSAYIPDAVWYDYETGAKRPWRKQRVEMSLPADKIGLHLRGGYIIPIQQPAVTTTASRMNPLGLIIALNDDNTAVGDFFWDDGETKDTVQNDNYILYTFAVSNNNLNITCTHELYSEGTTLAFQTIKILGVTETVTQVTVAENNQSMSTHSNFTYDPSNQVLLIENLNFNLGRNFRVQWDQTFLESEKITCYPDADIATQEKCTQRGCIWDTNTVNPRAPECYFPKTDNPYSVSSTQYSPTGITADLQLNPTRTRITLPSEPITNLRVEVKYHKNDMVQFKIFDPQNKRYEVPVPLDIPATPTSTQENRLYDVEIKENPFGIQIRRRSTGKVIWDSCLPGFAFNDQFIQISTRLPSEYIYGFGEAEHTAFKRDLNWHTWGMFTRDQPPGYKLNSYGFHPYYMALEDEGNAHGVLLLNSNAMDVTFMPTPALTYRVIGGILDFYMFLGPTPEVATQQYHEVIGHPVMPPYWSLGFQLCRYGYRNTSEIIELYEGMVAADIPYDVQYTDIDYMERQLDFTIDENFRELPQFVDRIRGEGMRYIIILDPAISGNETRPYPAFDRGEAKDVFVKWPNTSDICWAKVWPDLPNITIDESLTEDEAVNASRAHAAFPDFFRNSTAEWWTREILDFYNNYMKFDGLWIDMNEPSSFVNGTTTNVCRNTELNYPPYFPELTKRTDGLHFRTMCMETEHILSDGSSVLHYDVHNLYGWSQAKPTYDALQKTTGKRGIVISRSTYPTAGRWAGHWLGDNYARWDNMDKSIIGMMEFSLFGISYTGADICGFFNDSEYHLCTRWTQLGAFYPFARNHNIQFTRRQDPVSWNQTFVEMTRNVLNIRYTLLPYFYTQLHEIHAHGGTVIRPLMHEFFDDRTTWDIFLQFLWGPAFMVTPVLEPYTTVVRGYVPNARWFDYHTGEDIGIRGQVQDLTLLMNAINLHVRGGHILPCQEPARTTFLSRQKYMKLIVAADDNHMAQGSLFWDDGDTIDTYERDLYLSVQFNLNKTTLTSTLLKTGYINKTEIRLGYVHVWGIGNTLINEVNLMYNEINYPLIFNQTQAQEILNIDLTAHEVTLDDPIEISWS
What is the function of this protein?
Plays an important role in the final stage of carbohydrate digestion.  Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.
What are the official names of this protein?
Sucrase-isomaltase, intestinal.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 31 family.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type II membrane protein. Note=Brush border.
Protein: G3P_BPIF1
Sequence: MKKIIIALFFAPFFTHATTDAECLSKPAFDGTLSNVWKEGDSRYANFENCIYELSGIGIGYDNDTSCNGHWTPVRAADGSGNGGDDNSSGGGSNGDSGNNSTPDTVTPGQTVNLPSDLSTLSIPANVVKSDSIGSQFSLYTNASCTMCSGYYLSNNADSIAIANITETVKADYNQPDMWFEQTDSDGNHVKILQNSYKAVSYNVESKQSDVNNPTYINYSYSVNVKQVSYDTSNVCIMNWETFQNKCDASRAVLITDTVTPSYSRNITIQSNINYQGSNGSGGSGGSGGSGNDGGGTGNNGNGTGDFDYVKMANANKDALTESFDLSALQADTGASLDGSVQGTLDSLSGFSDSIGGLVGNGSAISGEFAGSSAAMNAIGEGDKSPLLDSLSFLKDGLFPALPEFKQCTPFVFAPGKEYEFIIECKYIDMFKGIFAFILYFWTFVTVYDSFSGILRKGRG
What is the function of this protein?
Plays essential roles both in the penetration of the viral genome into the bacterial host via pilus retraction and in the extrusion process.  During the initial step of infection, G3P mediates adsorption of the phage to its primary receptor, the tip of host I-pilus.  Subsequent interaction with the host entry receptor tolA induces penetration of the viral DNA into the host cytoplasm.  In the extrusion process, G3P mediates the release of the membrane-anchored virion from the cell via its C-terminal domain (By similarity).
What are the official names of this protein?
Attachment protein G3P, Gene 3 protein, G3P, Minor coat protein.
What is the protein family that this protein belongs to?
Belongs to the inovirus G3P protein family.
What are the subcellular locations of this protein?
Virion. Host membrane; Single-pass type I membrane protein. Note=Prior to assembly, G3P is found associated with the bacterial host inner membrane. There are about five copies of this protein per mature phage that are located on the head side of the filamentous virion.
Protein: EX7L_RHOBA
Sequence: MSDSTQFSLFDSGDDEPAKVTAPKRKVARKKRSSSSSDDAISISELTRQIKSTVESGFPGVWVAGEITDIARPRSGHLYFTLKDERSQIRGVMWRSVAERLPFELDDGQSVLCMGDVEVYAARGSYQLVVRKCQPQGMGALQLAFAQLQAKLQAEGLFEPERKRLLPRVPRRVAIVTSPTGAAIQDFLQAAAQRHAGIEIVLIPASVQGPGSVESLIDGMRAAHRMRPQPDVLIVSRGGGSLEDLWSFNDEQLVRAIAASRIPTVSAVGHEIDVTLADLVADVRALTPTDAASRVLPDRDSMVAALDALGQMMATNLFRRVHSERQRLENWESRPVFQNPFEMVHDRSREVDDWDERGRSAIWRRLEQAQAKLATVAAAQSALSPLAVLARGYSVTQTDAGKVVRSTGDVQPGDSLRTRLTDGDVISVVSRHESKPGNSDSA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD42_MOUSE
Sequence: MSLGMMEEEDLAEYFRLQYGERLLQLLQKFPNVEEQSDSPSIQLLEKKKEAKIMQEAMEHKKEAFQRRMETLNLRWEELGIKEEQLKAHIQKFEQFIQENDQKRIRALKKANKERELKRLRLRELAKAKQEMMALRLEHQKLSVKLQDYAIFNKYLEKVVENSEFEEIHEVIARYKTLVSMHHDLMQSAQEGQEKIERAKARLARYMEEKDDEILQHNNELARLQMRFDRARSDVIFWESRWAHIQNTAAKKTLLLGTIKMATLNLFQIVSKQLKESTQVSLEDTHKQLDMIQQFIQDLSDIWTEVKKKEQQQVRM
What is the function of this protein?
Required for sperm development.
What are the official names of this protein?
Coiled-coil domain-containing protein 42.
What is the protein family that this protein belongs to?
Belongs to the CFAP73 family.
Protein: DED1_COCIM
Sequence: MADSLKMAGLSLEDSQHAPSHATGRAPYIPPHLRGQQRAGPTMPVDGAAPQGRPPMNPGSWGPNGAPPNNWAPRGANNINGAPAWGAAGGGGARFDPNAYGHPGHRGGQSHGGAGSGAARGSGDGQWRDGKHIPGPPNARLERELFGVPNDPSKQHTGINFANYDDIPVEASGHDVPEPVTTFTNPPLDDHLISNIKLATYKTPTPVQKYSIPIVMGGRDLMACAQTGSGKTGGFLFPILSQAFKNGPSAVPTQNANQFSYGRQRKAYPTSLILAPTRELVSQIYDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLCNIKYLVLDEADRMLDMGFEPQIRRIVEGEDMPPVNGRQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKVEYVEDADKRSVLLDILHTHGTGLTLIFVETKRMADSLSEFLINQNFPATAIHGDRTQRERERALEYFRNGRCPILVATAVAARGLDIPNVTHVVNYDLPTDIDDYVHRIGRTGRAGNTGLSTAFFNRGNRGVVRDLIELLKEAHQEVPAFLENIAREGSGYGGRGGGRGGGRGRGANATRDMRRMGGGGPPMSGTPSYSGGYGGGANNYGGSYSSAPSYGGYGGGYGGGSYGNPSGPTGPSSWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DED1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IZH3_YEAST
Sequence: MMDSSSKSLTQYIPSPMGSLSRLKQKGVDNFQKVKKSGKSIYNYNYSKFVPHPFSTIDESVKHSESGRYDDLEIIRPTKEKEVTSSVYKRNSGKSLNTESQFSLGDSDAATLVNSVATFKLNNASTSTSLVSSSSTVCSQAKSSLRSPTSRLNDTKIKEENNYISSVKDYCGPMRKSMVKTEILIEEPLNPTTDIKSFINSYNHGKAYSLGETQHLHYYQLPFPWRENRYIIHGYRFYNTHSKSLLSIFNWYGWHNETSNIWSHLLGAIYIIYLAIYDFPQSEVWRNSQVPPQARWIVFMFLAAALKCMLSSVFWHTFNGTSFLKLRSKFACVDYSGITILITASILTTEFVTMYSCYWAMYTYMSISLALGVFGVFMNWSPRFDRPEARPLRIRFFILLATMGVLSFLHLIFLTDLHYAATLFSPVTYKSVVWYLVGVVFYGSFIPERFRSDVQVDKTIPTNYELSTDLEIITKQREIHFREVPTAHSKCSSCPSHAKSFKSLWWVDYFGCSHTFWHFFVVLGVIGHYRAILDMFAKRWILS
What is the function of this protein?
ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.
What are the official names of this protein?
ADIPOR-like receptor IZH3, Implicated in zinc homeostasis protein 3.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.