PharMolix/UniProtQA huggingface dataset:
Protein: Y1811_CITK8
Sequence: MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLNTFFPWIEKQGLTVGIIILTIGVMAPIASGSLPPSTLIHSFVNWKSLVAIAIGVFVSWLGGRGVTLMGSQPQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIIGKQ
What are the official names of this protein?
UPF0756 membrane protein CKO_01811.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUA_GEODF
Sequence: MRNIKLIIEYDGTAYCGWQLQPNGITIQQVIEESLEKMLGQSVRLQSSGRTDAGVHALGMVAVFKTQKDLPVRAFSDGLNCLLPPDIAIRDASEVPLSFNPRADAISKHYRYTIYNSKRRSPLTRLNSWHLRGILNMELMQLGASHFVGEHDFAAFRASNCVAKTTIRRMFHVSVAKVGDSVIIDVHGSGFLKNMVRVIAGTLVAVGQGKLDPSAIPGLLAGGDRSASGITAPPQGLCLMEVFY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GBLPA_ORYSJ
Sequence: MAGAQESLVLAGVMHGHNDVVTAIATPIDNSPFIVSSSRDKSLLVWDLTNPVQNVGEGAGASEYGVPFRRLTGHSHFVQDVVLSSDGQFALSGSWDGELRLWDLSTGVTTRRFVGHDKDVLSVAFSVDNRQIVSASRDRTIKLWNTLGECKYTIGGDLGGGEGHNGWVSCVRFSPNTFQPTIVSGSWDRTVKVWNLTNCKLRCNLEGHGGYVNAVAVSPDGSLCASGGKDGVTLLWDLAEGKRLYSLDAGSIIHSLCFSPNRYWLCAATQDSIKIWDLESKHIVQDLKPEIPVSKNQMLYCTSLNWSADGSTLYAGYTDGTIRIYKISGFSYAG
What is the function of this protein?
Component of the RACK1 regulatory proteins that functions in innate immunity by interacting with multiple proteins in the RAC1 immune complex.  Acts as positive regulator of reactive oxygen species (ROS) production and is required for resistance against rice blast (M. grisea) infection.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-like protein A, GPB-LR, RWD, Receptor for activated C kinase 1A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Predominantly found in the cytoplasm.
Protein: Y891_MYCTU
Sequence: MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARVRISALGSLDLRYHSLRCYAAPPDVGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEESTHLWQMCPEDMATAIAHLDHTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALDLQRTSLAPIRLRIGLHTGEVQLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVTGRLPADAWLVDLGRHPLRGLPRPEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTTFVGRRAQIS
What are the official names of this protein?
Uncharacterized protein Rv0891c.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Protein: THIE_METAR
Sequence: MQYDLYVVTDEGLSRGLTHPELARRAIAGSADVIQLRDKKCDCDYLLRCAMEMREDCNKAGVTFIVNDRLDVALQSQADGVHIGQSDMPLKFARRVAPKGFIIGVSAGTVEEALRAEHDGADYIGFGPVFPTGSKADAGPVCGLDLLREVRRRVSIPVVAIGGINAANAPEVLAAGADGLAVISAVVSQEDVTAAARNLKAIISQYRLSGRQ
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RS19_ACIF2
Sequence: MPRSIKKGPFIDEHLDRKVQSAQASNSRRPIKTWSRRSTITPDFIGLTISVHNGRQHIPVVVNENMVGHKLGEFALTRTFKGHVADKKAKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: DER_ALKOO
Sequence: MARPIVAVVGRPNVGKSTLFNKIAGERISIVENKPGVTRDRIYAEAEWLNYQFTLIDTGGIEPESEEIIPAQMRRQAELAMETANVIIFVVDGREGLTSVDRDVAELLRKTKKPVIVTLNKVDTRHQSEHFYEFYELGMGDPIEISASLGLGIGDLLDEVVKNFNPEDYNQYDDDVIKVAMIGKPNVGKSSLINRILGEERVIVSDIAGTTRDAIDTPFTDGDDRYVLIDTAGIRRKSRITESIEKYSIVRAIAAVEKSDVCLLVIDASEGVTEQDKKIAGYSHENGKGMVIVVNKWDIIEKDNHTMNEFIKEIRNELTYISYAPIVFVSALTGQRMNKILEEVKHVSNQNAMRIPTGALNEVIGEAILLNQAPSDKGKRLKVFYATQASVKPPTFILFINDKELMHFSYLRYLENKIRENFGFEGTPIRFILREKTGRD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: CHID1_XENLA
Sequence: MRLLSTLLLVATTYPLISATLSKTDSKKAASKAPETKTRLSDTSVQSRGLVSTDVKAKDIVLEHRSYCAKKLKERHVSADVLGYVTPWNGHGYDIAKTFAAKFTLISSVWLQIRRKGREAYQVTGLHDVDQGWIKDIRKTSKSTQIVPRILFDGWSYQDFESVFNSEDEIEELAGAMVQTAKDEHFDGFVVEVWSQLGGQKRQELVHLLIHIGEALHSAKLHFILVIPPAVAPGTDQLGMFGRKEFDQLAPVVDSFSLMTYDYSSPQRPGPNSPISWVQACVQLLDPESKWRKKILLGLHFYGMDYSALGATGEPILGNRYVEILKEHKPKLLWDQQIAEHYLEYKKNKGGKHAVFYPTLKSIQVRLDLAEELGTGIAIWELGQGLDYFYDLL
What are the official names of this protein?
Chitinase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Secreted. Lysosome.
Protein: PIMT2_METAC
Sequence: MVLVNAISEKDYIKDSRRRKKEEKEFEKLRKLLVEGLEDIVRDKKVLKAMFRVPRHRFVPEYEQRAAYTDRPLEIGHGQTISTPHTVALMCEILELSEGHKVLEIGTGSGYNAAVMAELVGKTGHIYSVERIEPLVNFARKNLEQMGYDNVTVLLENGSMGYPRYAPYDRIAVTCAAPTIPKALLEQLKPGGIMVIPVGDYSQELIRVKKDSNGNIYKKRKGEVIFVPMLGRHGFPRS
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins (By similarity).
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase 2, L-isoaspartyl protein carboxyl methyltransferase 2, Protein L-isoaspartyl methyltransferase 2, Protein-beta-aspartate methyltransferase 2, PIMT 2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_STAAT
Sequence: MLNPPLNQLTSQIKSKYLIATTAAKRAREIDEQPETELLSEYHSFKPVGRALEEIADGKIRPVISSDYYGKE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RS9_MYCSS
Sequence: MTEAVETETVEPTTDEATAADVEPREPVYIDRPIQTVGRRKEAVVRVRLVPGTGKFNLDGRTLEAYFPNKVHQQLIKAPLVLVDRLESFDVYAHLDGGGPSGQAGALRLAIARALILVQPEDRPALKKAGFLTRDPRAIERKKYGLKKARKAPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RS16_CLONN
Sequence: MAVKIRLRRMGAKKAPFYRVVVADSRSPRDGRFVEEIGYYNPISEPKAIKIDEEKAIKWVKNGAQPTDVVKRLFKEAGIDEKLSK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: SLC31_RAT
Sequence: MNEDKDKRDSIQMSMKGCRTNNGFVQNEDIQEQDPDSRDTPQSNAVSIPAPEEPQLKVVRPYAGMPKEVLFQFSGQARYRVPREILFWLTVVSVFLLIGATIAIIIISPKCLDWWQAGPMYQIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTIWITSFYKSPLKDFRYAVEDFKEIDPIFGTMKDFENLVAAVHDKGLKLIIDFIPNHTSDKHPWFQSSRTRSGKYTDYYIWHNCTHANGVTTPPNNWLSVYGNSSWQFDEERKQCYFHQFLKEQPDLNFRNPAVQEEIKEIIKFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQIPDTVTRYSELYHDFTTTQVGMHDLVRDFRQTMNQFSREPGRYRFMGTEVSAESTERTMVYYGLSFIQEADFPFNKYLATLDTLSGHTVYEAITSWMENMPEGKWPNWMIGGPETSRLTSRVGSEYVNAMNMLLFTLPGTPITYYGEEIGMGDISITNLNERYDTNALLSKSPMQWDNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHARELLLSRGWFCLLRDDNHSVVYTRELDGIDKVFLVVLNFGESSTVLNLQETISDVPTKLRIRLSTNPASKGSDVDTHAVSLEKGEGLILEHSMKTLLHHQKAFRDKCFISNRACYSSVLDLLYSSC
What is the function of this protein?
Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:1376924, PubMed:1729674) (By similarity).  Acts as a chaperone that facilitates biogenesis and trafficking of functional SLC7A9-SLC3A1 heteromers to the plasma membrane.  SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity).  Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (By similarity).  Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity).
What are the official names of this protein?
Neutral and basic amino acid transport protein rBAT, D2, Solute carrier family 3 member 1, b(0,+)-type amino acid transport protein, NAA-TR.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: SE14_ORYSJ
Sequence: MPPQPPPAASASASAPDPAVPAWLRGLPRAPEYRPTESEFADPIAFLSRVEREAAAYGICKVIPPHPRPSRRFVFAHLNRSLVSSCDAPAPSPAAASDSSIPPSSSSPPPVSAAVFTTRHQELGNPRRGRPTPQVLKQVWQSGERYTLDQFESKSRAFSKTHLAGLHEPTALAVESLFWKASADRPIYIEYANDVPGSGFAAPVQLQRKKKQKRETAPMDEWEKSSGWRLSNSPWNLQAIARAPGSLTRFMPDDVPGVTSPMVYIGMLFSWFAWHVEDHDLHSLNFLHTGAPKTWYAVPGDRAVELEEVIRVHGYGGNTDRIASLAVLGEKTTLMSPEVLIDNGVPCCRLVQYPGEFVVTFPRAYHVGFSHGFNCGEAANFATPQWLKFAKEAAVRRAVMNYLPMLSHQQLLYLLAVSFISRNPRELLSGIRTSRLRDRKKEDRELLVKQEFLQDMISENELICSFLGKKSVDNVVLWEPDLLPSLTALHPCSSCSKAPEKKGEDGPRIGSTQSSSKDDSSSDGTACMTGTQSKGLSMDSKQAPEGEKLDTDDGDDLPFDLSIDSGSLTCVACGILGYPFMAILQPSRKALEEISLVDKERYKLSCEKEICSNVLPCSPNDGSSGCPLIANRSSSPVENANLSHQDVKPIRSDISLMGKEFNGTLGKHIGTSCSCSSENTIHPYGDTETPEKKIPSDCPGSELSKQSGRGDVNVPDVEGSEETISWNTGCAFARPRIFCLQHALEIEELLASKGGVHALIICHADYVKLKALAISIAEEIEFQFDYKDVALANASKSNLHLINISIDDEGYEEEGTDWTSRMGLNLKHSSKIRKETPESQEQPPLSFWGLFSKPSPISVVSNLKWLCRKARTPYKVIGYASSPDVVATPDKVKPAVTKTQIDTSGNAHENIGSEQTLQQDCVLQESNDVADMCKRPKVNDQDGHSLINIPIAVAEYPMMHQVCERPVSVSACDDPICSFDSQDSPTTVAVSAGKPTREQCGAESTELSTVKQFLDNGLIAEGGSMNFISNHEHLESDNATSVCKDEQLQVQQDQLAMVLCNNPNTELVAGELHGGAASSTLENEDSCGNTSYCSDTVLKNSEPDTDDQPETCDRSVVLVTPKSSCDQMISSSDRSCSLTLDCPVSTDAAFSSEKLSMAHDLMGSELQAVHNSKAEVVASLTDVKGAKLNSIHTTQLPHESPSSDFIISEGAQSASTTAIPRKNGTSMHTESNSIDILLGVLADESKVSSGKDEVGKASLTLMTLAGNDQSADDVTQDEVAEITDPSHGFCSSDIVSRSIGSSNRTNIICYARRKHKRKSGSEFNINSPQSLGSFVRSPCESLRPRTRPAIVEDMTNETKTAEASTANKRKKAKVEAFQCDIEFCDMTFETKAELRAHQRNICTDESCGKRFSSHKYLKRHQCVHRDERPFKCPWDGCPMTFKWLWAQTEHIRVHTGERPYKCSAPDCGQSFRYVSDYSRHRKKFNHY
What is the function of this protein?
Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3.  Involved in the control of flowering time.  Has a suppressive effect on floral transition under long day conditions through the demethylation of H3K4me3 in the promoter region of the flower-promoting signal HD3B/RFT1.
What are the official names of this protein?
Probable lysine-specific demethylase SE14, Protein PHOTOPERIOD SENSITIVITY 14.
What are the subcellular locations of this protein?
Nucleus.
Protein: RHAT_ECOHS
Sequence: MSNAITMGIFWHLIGAASAACFYAPFKKVKKWSWETMWSVGGIVSWIILPWAISALLLPNFWAYYSSFSLSTLLPVFLFGAMCGIGNINYGLTMRYLGMSMGIGIAIGITLIVGTLMTPIINGNFDVLISTEGGRMTLLGVLVALIGVGIVTRAGQLKERKMGIKAEEFNLKKGLVLAVMCGIFSAGMSFAMNAAKPMHEAAAALGVDPLYVALPSYVVIMGGGAIINLGFCFIRLAKVKDLSLKADFSLAKSLIIHNVLLSTLGGLMWYLQFFFYAWGHARIPAQYDYISWMLHMSFYVLCGGIVGLVLKEWNNAGRRPVTVLSLGCVVIIVAANIVGIGMAN
What is the function of this protein?
Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).
What are the official names of this protein?
L-rhamnose-proton symporter, L-rhamnose-H(+) transport protein.
What is the protein family that this protein belongs to?
Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLPK1_THEMA
Sequence: MYVLAIDQSTSGTKAIIFDEKGGIVHRVTVYHKQYYPKPGWVEHDPEEIFRNTLDACRKVIEESGIKPLEIEALAITNQRETTILWEKKSGKPVYNAVVWQCQRGASLCEEIKKRGLEGKIKEKTGLVVDPYFSASKIRWILDNVEGVKNKAKQGEIAFGTVDSWLIWKLTKGEVHATDFSNASRTLLLNIHELRWDEEVLEIFEIPPEILPELKSSDSVFGYTDLGFLPKKIPIVGVMGDSSAALFGQGGFYSGDIKVTYGTGSSTMLNIGEKPNVSDSPIVCSVGWVVKETSSYVLEGNIHSAGDTIVWLKEKLGIISDPSETEKIALSLENNGGVYLVPAFVGLGAPYWRSDVKAAILGLQRNHGKEHVVRAALESIAYQVRDIFEEMVRISSKEPTEVRADGGITRNRFLMQFQADILNIPVLVSNIEEVSARGVAFVALLHLGAFSDLEEIRQKITYREKYEPRMGDELREMYYEGWKTAIRKLLTE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase 1, ATP:glycerol 3-phosphotransferase 1, Glycerokinase 1, GK 1.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: KCJ18_HUMAN
Sequence: MTAASRANPYSIVSLEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIAFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEGHGRTPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECLVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYRRGSEI
What is the function of this protein?
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.  Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.  The inward rectification is mainly due to the blockage of outward current by internal magnesium.
What are the official names of this protein?
Inward rectifier potassium channel 18, Inward rectifier K(+) channel Kir2.6, Potassium channel, inwardly rectifying subfamily J member 18.
What is the protein family that this protein belongs to?
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NDK_HYDCU
Sequence: MLERTFSIIKPDAVKRNLIGQIVSKLEQNGLKVIASKMVFLTVQEAKGFYAEHDGKPFFDTLIKNMTAGPIVVQVLEGDDAIAKNREIMGPTDPENAPAGSIRKEYAISMQQNSVHGSDSPESAQREISYFFSEIEVFSAS
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIW_CLONN
Sequence: MKLETKCHGIIEYKEEDVIEFKKGIPGFNELKRFINFPIEDNEVFSVLHSIENNEIGFIVTSPFSIIKDYEINLDDSVIERLNIENEKDVLVLNTVTLHSKLENITVNLCAPIVINIKTKLGEQIILNNGKYQIKHPLFKEGI
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMN_SALTI
Sequence: MSEQQIDWDLALIQKYNYSGPRYTSYPTALEFSEDFEDAAFLQAVARYPERPLSLYVHIPFCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIRHRAPLFADRHVSQLHWGGGTPTYLNKAQISRLMTLLRENFHFNTDAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHARDIGFTSTNIDLIYGLPKQTPESFAFTLKRVTELNPDRLSVFNYAHLPTLFAAQRKIKDADLPSAQQKLDILQETIVSLTQAGYQFIGMDHFARPDDELAVAQREGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDGYMQNQKELKRYYQQVDERGNALWRGITLTRDDCIRRDVIKALICNFRLDFNAVEQQWGLHFAEYFAEDLQLLSPLAKDGLVDISEKGIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
What are the official names of this protein?
Oxygen-independent coproporphyrinogen III oxidase, CPO, Coproporphyrinogen III dehydrogenase, CPDH.
What is the protein family that this protein belongs to?
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_MOOTA
Sequence: MNWGEQVASRRQRVHEQRPLVHHITNLVVTNLTANVTLAIGASPVMAYAREEVADMARLAQAVVLNMGTLTGDVVEAMLLAGKAANNAGIPVVFDPVGAGATPFRTRTAQKIIKELHIDILRGNASEIASIGGFGGHTKGVDAAGAPARVAEMVKQVARDLNTVVAVTGATDYISDGERLIAVDNGHPLLTFVTGTGCSATSIIAAFRAVEEDGVTASTAALAYYGLAAERAAAVSQGPASFQVALLDTLYNLAGEELARGVKIRLL
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: G3P_FELCA
Sequence: MVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGKPITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDHFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKAAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
What is the function of this protein?
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively.  Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity).  Modulates the organization and assembly of the cytoskeleton.  Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity).  Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.  Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.  Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity).  Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis.  Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, Peptidyl-cysteine S-nitrosylase GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Nucleus. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks.
Protein: HIS1_STAA9
Sequence: MLRIAIAKGRLMDSLINYLDVIEYTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGMADIGIVGSDILDERQYNVNNLLNMPFGACHFAVAAKPETTNYRKIATSYVHTAETYFKSKGIDVELIKLNGSVELACVVDMVDGIVDIVQTGTTLKANGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_PECCP
Sequence: MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRVVEGTQFECLKDTFVGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELIPAAQIDRLATLPTYEEALARLMSTMKEAAAGKLVRTLAAVRDAKEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RFAH_ECOL5
Sequence: MQSWYLLYCKRGQLQRAQEHLERQAVNCLAPMITLEKIVRGKRTAVSEPLFPNYLFVEFDPEVIHTTTINATRGVSHFVRFGASPAIVPSAVIHQLSVYKPKDIVDPSTPYPGDKVIITEGAFEGFQAIFTEPDGEARSMLLLNLINKEIKHSVKNTEFRKL
What is the function of this protein?
Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.  RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons.  Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites.  Termination signals are bypassed, which allows complete synthesis of long RNA chains (By similarity).  Also negatively controls expression and surface presentation of AG43 and possibly another AG43-independent factor that mediates cell-cell interactions and biofilm formation,.
What are the official names of this protein?
Transcription antitermination protein RfaH.
What is the protein family that this protein belongs to?
Belongs to the RfaH family.
Protein: KATG_MYCTU
Sequence: MPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNLKVLHQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIRMAWHAAGTYRIHDGRGGAGGGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWADLIVFAGNCALESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAAVQMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGAGPADLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTNTPTKWDNSFLEILYGYEWELTKSPAGAWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDLSLRVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDMGPVARYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASLKSQIRASGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKVIRTLEEIQESFNSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQEQTDVESFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEMTVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKDGSGKVKWTGSRVDLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR
What is the function of this protein?
Catalyzes the oxidative activation of the antitubercular pro-drug isoniazid (INH) to generate an isonicotinoyl radical that then reacts nonenzymatically with NAD to form an isonicotinoyl-NAD adduct which inhibits InhA.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.