PharMolix/UniProtQA huggingface dataset:
Protein: ARTN_MOUSE
Sequence: MELGLAEPTALSHCLRPRWQSAWWPTLAVLALLSCVTEASLDPMSRSPAARDGPSPVLAPPTDHLPGGHTAHLCSERTLRPPPQSPQPAPPPPGPALQSPPAALRGARAARAGTRSSRARTTDARGCRLRSQLVPVSALGLGHSSDELIRFRFCSGSCRRARSQHDLSLASLLGAGALRSPPGSRPISQPCCRPTRYEAVSFMDVNSTWRTVDHLSATACGCLG
What is the function of this protein?
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex.  Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity).  Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
What are the official names of this protein?
Artemin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family. GDNF subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: M3A_CONQU
Sequence: CCSQDCLVCIPCCPN
What is the function of this protein?
Causes scratching in mice.
What are the official names of this protein?
Conotoxin QcIIIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SPAS2_HUMAN
Sequence: MSRKQNQKDSSGFIFDLQSNTVLAQGGAFENMKEKINAVRAIVPNKSNNEIILVLQHFDNCVDKTVQAFMEGSASEVLKEWTVTGKKKNKKKKNKPKPAAEPSNGIPDSSKSVSIQEEQSAPSSEKGGMNGYHVNGAINDTESVDSLSEGLETLSIDARELEDPESAMLDTLDRTGSMLQNGVSDFETKSLTMHSIHNSQQPRNAAKSLSRPTTETQFSNMGMEDVPLATSKKLSSNIEKSVKDLQRCTVSLARYRVVVKEEMDASIKKMKQAFAELESCLMDREVALLAEMDKVKAEAMEILLSRQKKAELLKKMTHVAVQMSEQQLVELRADIKHFVSERKYDEDLGRVARFTCDVETLKKSIDSFGQVSHPKNSYSTRSRCSSVTSVSLSSPSDASAASSSTCASPPSLTSANKKNFAPGETPAAIANSSGQPYQPLREVLPGNRRGGQGYRPQGQKSNDPMNQGRHDSMGRYRNSSWYSSGSRYQSAPSQAPGNTIERGQTHSAGTNGTGVSMEPSPPTPSFKKGLPQRKPRTSQTEAVNS
What are the official names of this protein?
Spermatogenesis-associated serine-rich protein 2, Serine-rich spermatocytes and round spermatid 59 kDa protein, p59scr.
What is the protein family that this protein belongs to?
Belongs to the SPATS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_SODGM
Sequence: MHILLSNDDGIHAPGIQQLAEALRTLAFVQIVAPDRDRSGVSNSLTLDAPLRMQTHPNGDIAILSGTPTDCVYLGVNALMRPGPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGYPALAVSLNGTRHFATAAAVTCRLLRALTSTPLRTGKILNVNVPDLPLSSLKGYKVTRCGSRHPASEVIRQTDPRGREMLWIGPPAGSFDAGADTDFDAVNRGYVSLTPLQVDLTASAALPVLSDWLGDTEGLGSW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_CLOPE
Sequence: MPKMKTHRGAAKRFKKTGTGKLKRAHAFTSHILTKKSAKRKRNLRKTGYVSTAQEKAMKKLLPYL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RNZ_STRPB
Sequence: MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRSFQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFEVYAERLAHTIFCMGYRVVQKDLEGTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYGKGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKMVQDLEEVII
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: MK01_HUMAN
Sequence: MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
What is the function of this protein?
Acts as a transcriptional repressor.  Binds to a [GC]AAA[GC] consensus sequence.  Repress the expression of interferon gamma-induced genes.  Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1.  Transcriptional activity is independent of kinase activity.
What are the official names of this protein?
Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane, caveola. Cell junction, focal adhesion. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization.
Protein: UPPP_CERS1
Sequence: MLDSTTLVALVLGLLEGLTEFIPVSSTGHLLLAGHFLGFESAGRSFEVVIQLGAVLAVLTVYAAKLVSVIRAAPHDPRAFRFLVAVLVAFLPAVVIGVLAHGFIKAVLFETPILIATMLILGGIVLLFVDRMAPEPRYDDAMDLPLNVALKIGFIQCLAMVPGVSRSGATIVGGLMLGAGKRAAAEFSFFLSMPTMAGAFAFDLFKNRDVLDASALGEIAVGFVAAFVAAVLVVRWLLGYVSRHGYALFGWWRIAVGSVALAALLAGY
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FADA_PSEAB
Sequence: MSLNPRDVVIVDFGRTPMGRSKGGMHRNTRAETMSAHLISKLLERNPKVDPAEVEDVIWGCVNQTLEQGWNIARMASLMTQIPHTSAAQTVSRLCGSSMSALHTAAQAIQTGNGDVFVIGGVEHMGHVGMMHGVDPNPHLSLYAAKASGMMGLTAEMLGKMHGISREAQDKFGARSHQLAWKATQEGKFKDEIIPMEGYDENGFLKVFDFDETIRPETTVETLAQLKPAFNPKGGTVTAGTSSQITDGASCMIVMSAQRAQDLGIQPMAVIRSMAVAGVDPAIMGYGPVPSTNKALKRAGLTIADIDFVELNEAFAAQALPVLKDLKLLDKMDEKVNLHGGAIALGHPFGCSGARISGTLLNVMKQNGGTLGVSTMCVGLGQGITTVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HNF1B_XENLA
Sequence: MVSKLSPLQQELLNALLNSGVTKEDLIQALDDMIPSPSFGVKLENLHMSPEHESDNKPVFHTLTNGHHHKGKLSGDEGSEDGDDFDTPPILKELQSLNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDITGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREIVIQFNQTVQGSGNITGKSSQDQLLFLFPEFNQQNPVPGQPDDSCSEPANKKMRRNRFKWGPASQHILYQAYERQKNPSKEEREALVEECNRAECIQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSTGPSHPHNLNSLLSHGSPHHTQPSTSPPSKLQGMRYNQQGNNEVTSSSTISHHGNNAMVHSQSVLQQVSPVGLDHSHSMLSPDGKLISVSGGGLPPVSTLTNIHNLSQSVHHNHQQSQNLIMAPISGVMAITQNLNTSQAQSVPVINSVAGSLAALQSVQFSQQLHSPHHQQIMQQSSGHMAQQPFMATVTQLQNSHMYAHKHEPPQYSHTSRFPSAMVVTDTSSISTLSNMSSSKQCPLQAW
What is the function of this protein?
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
What are the official names of this protein?
Hepatocyte nuclear factor 1-beta, HNF-1B, LFB3, XlFB3.
What is the protein family that this protein belongs to?
Belongs to the HNF1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GSA_ENT38
Sequence: MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIERADGAFLYDVDGKAYIDYVGSWGPMVLGHNHPTIRNAVIEAAQRGLSFGAPTEMEVKMAELVTELVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCTYNDLDTVRAAFEQYPQEVACIIVEPVAGNMNCIPPQPDFLPGLRALCDEFGALLIIDEVMTGFRVALAGAQSYYDVVPDLTCLGKIIGGGMPVGAFGGRKDVMEALAPTGPVYQAGTLSGNPIAMAAGFACLTEVAQPGIHETLTDLTAQLANGLLEAAEETGVPLVVNHVGGMFGIFFTDAKTVTCYQDVVKCDVERFKRFFHLMLEEGVYLAPSAFEAGFMSVAHSVEDINKTIDAARKVFAKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHBD3_MOUSE
Sequence: MHAWEAPGSLSRALPLASSVLMLLLSCLWLLGAGPSLRLAPELLMEPWQVHRLLTHALGHTALPGLLLSLLLLPTLGWWQECHLGTVRFLHNSTVLALATGLLAVLLAGLGVSGAAGGCGYMPVHLAMLAGQSHHPGWPQRTLPPWLLPWLLLALTLLLSSEPPFLQLLCGLLTGLAYAAGAFQWLELSEQRLQVLQEGVLCKSLARCWPLRLFPTPGSLGELPVTYPAGVRPATPRPPYLASSDSWPHSDGSAQLPPRLGPGQLTWKNSERGLDWAGSSFASATTMWAALDEQMLQEGIQASLLDVSVQGSQSSLWLPKPSVSSLRLQQLQHMGFPTEQAAVALAATGRVEGAVSLLVEGLVDTEALVTEGRSSPAHCTGTGAS
What are the official names of this protein?
Rhomboid domain-containing protein 3.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MOT11_HUMAN
Sequence: MPAPQRKHRRGGFSHRCFPTPQTAMTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYIGLPRALPSCGPASPPATPPPETGELLPAPQAVLLSPGGPGSTLDTTC
What is the function of this protein?
Proton-linked monocarboxylate transporter.  It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119).  Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).
What are the official names of this protein?
Monocarboxylate transporter 11, MCT 11, Solute carrier family 16 member 11.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: LA_RABIT
Sequence: GKVEFQGKKTKFDSDDERNENGAAGPVKRAREETDKEEPASKQQKTENGAGDQ
What is the function of this protein?
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
What are the official names of this protein?
Lupus La protein homolog, La autoantigen homolog, La ribonucleoprotein.
What are the subcellular locations of this protein?
Nucleus.
Protein: FUMC_STAAC
Sequence: MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAAIANFDLGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEFGDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYNS_NEOFI
Sequence: MSLATLDATQHPNLPASAATLFKAKAQNKLSFEQIAQHIGRNEVATAALFYGQAKASPEDIQKLSELLNISPQVLEEQLSGFPDRGRSVEMPPKEPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTKVEKETDADGNNWAVITLRGKWLPFSRF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: ONCO_CAVPO
Sequence: MSITDVLSADDIAAALQECQDPDTFEPQKFFQTSGLSKMSASQVKDVFRFIDNDQSGYLDEEELKFFLQKFESGARELTESETKSLMAAADNDGDGKIGADEFQEMVHS
What is the function of this protein?
Has some calmodulin-like activity with respect to enzyme activation and growth regulation.  Binds two calcium ions (By similarity).
What are the official names of this protein?
Oncomodulin, OM, CBP-15, Parvalbumin beta.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: COFI_OGAPD
Sequence: MSRSGVAVSDEALKAFNDLKLGKKFKSIIYKLNDAKTEIVVDSTSTEDAYDAFVEDLPENDCRYAVYDFEYEVGQGDGKRNKIVFYQWSPDTASVRAKMVYASSKDALRRALNGIGTEIQGTDFSEVAYESVLEKISRTTGLH
What is the function of this protein?
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner.  It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin.  Binding to F-actin is regulated by tropomyosin.  It is the major component of intranuclear and cytoplasmic actin rods.  Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends.  In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments.  Involved in the maintenance of the contractile ring once formed.  In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).
What are the official names of this protein?
Cofilin, Actin-depolymerizing factor 1.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Note=Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.
Protein: YCF3_DIOEL
Sequence: MPRSQINGNFIDKTSSIVANILLRIIPTTSGEKKAFTYYRDGAIMSAQSEGNYAEALQNYYEATRSEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFQAIERNPFLPQAFNNMAVICHYQGERAILRGDSEIAEAWFDQAAEYWKQAIGLTPGNYIEAHNWLKITRRLEFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: EGLB_ASPNG
Sequence: MKFQSTLLLAAAAGSALAVPHGSGHKKRASVFEWFGSNESGAEFGTNIPGVWGTDYIFPDPSTISTLIGKGMNFFRVQFMMERLLPDSMTGSYDEEYLANLTTVVKAVTDGGAHALIDPHNYGRYNGEIISSTSDFQTFWQNLAGQYKDNDLVMFDTNNEYYDMDQDLVLNLNQAAINGIRAAGASQYIFVEGNSWTGAWTWVDVNDNMKNLTDPEDKIVYEMHQYLDSDGSGTSETCVSGTIGKERITDATQWLKDNKKVGFIGEYAGGSNDVCRSAVSGMLEYMANNTDVWKGASWWAAGPWWGDYIFSLEPPDGTAYTGMLDILETYL
What is the function of this protein?
Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan.  Involved in the degradation of complex natural cellulosic substrates.
What are the official names of this protein?
Endo-beta-1,4-glucanase B, Endoglucanase B, Carboxymethylcellulase B, Cellulase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GSHB_MACFA
Sequence: MATNWGSLLQNEQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVNQNAAFLEQTLSSTIEQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSTDGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKILSNNPSKGLALGIAKAWELYGSTNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFEDISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSCAAKCPDIATQLAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDMGEEGDQAIAKALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKTEPEPFENCLLRPGSPAQVVQCISELGIFGVYVRHEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
What is the function of this protein?
Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner.  Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes.
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic GSH synthase family.
Protein: MED21_DROME
Sequence: MADRLTQLQDTVNQQAEHFCNAIGVIQQTSLPSKFVNFERIGPQTPIPCPPQEDYAQLFAQLIARCAKDIDTLIESLPNEDSSIELQNSSLKRLEIENQGTARDLEEVVQKGELLLEKMQYSLECIAQAQLDMQITLKHDLQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Required for activated transcription of the MtnA, MtnB and MtnD genes.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21, dMED21, dSRB7, dTRAP19.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS4_LIMRD
Sequence: MSRYTGPSWRVSRRLGVSLSGTGKELARRAYAPGDHGRDRRGKLSEYGTQLREKQKLRFMYGMTERQFSNLFVRAGKIKEGTHGANFMALLERRLDNMVYRLGLATTRRQARQLVNHGHITVDGKRVDIPSYEVKVGQIIAVRDKSKNLDIIKNAVEAVVSRPSYVDFDADKLEGKLNRIPAREDMNADIDEALIVEFYNK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NCAP_EBORR
Sequence: MDRGTRRIWVSQNQGDTDLDYHKILTAGLTVQQGIVRQKIISVYLVDNLEAMCQLVIQAFEAGIDFQENADSFLLMLCLHHAYQGDYKLFLESNAVQYLEGHGFKFELRKKDGVNRLEELLPAATSGKNIRRTLAALPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKYLLIHQGMHMVAGHDANDAVIANSVAQARFSGLLIVKTVLDHILQKTDQGVRLHPLARTAKVRNEVNAFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAESRELDSLGLDDQERRILMNFHQKKNEISFQQTNAMVTLRKERLAKLTEAITLASRPNLGSRQDDGNEIPFPGPISNNPDQDHLEDDPRDSRDTIIPNGAIDPEDGDFENYNGYHDDEVGTAGDLVLFDLDDHEDDNKAFEPQDSSPQSQREIERERLIHPPPGNNKDDNRASDNNQQSADSEEQGGQYNWHRGPERTTANRRLSPVHEEDTLMDQGDDDPSSLPPLESDDDDASSSQQDPDYTAVAPPAPVYRSAEAHEPPHKSSNEPAETSQLNEDPDIGQSKSMQKLEETYHHLLRTQGPFEAINYYHMMKDEPVIFSTDDGKEYTYPDSLEEAYPPWLTEKERLDKENRYIYINNQQFFWPVMSPRDKFLAILQHHQ
What is the function of this protein?
Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response.  VP35 binds to and stabilizes monomeric NP, keeping it soluble.  Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released.  The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication.  The nucleocapsid is helical with a pitch of 10. 81 NP per turn and a diameter of about 22nm.  Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid.  Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription.  Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N, Reston NP, rNP.
What is the protein family that this protein belongs to?
Belongs to the filoviruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: RK36_VITVI
Sequence: MKIRASVRKICEKCRLIRRRGRIIVICPNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LFTR_BURVG
Sequence: MVPWLDPNDPFPPVERALGPATGAPGLLAASADLLPSRLIDAYLRGIFPWYSDGQPVLWWSPDPRMILAPAEFKVSPSLRKTLKRVLRDAAWEVRVDHDFAGVMRACAQAPRRGQRGTWITAEIIDAYTSLHRSGNAHSIETWHDGRRVGGLYGVAFGRMFFGESMYADATDASKIALATLVAHLRDQGLEMIDCQQNTSHLASLGGREIARKAFVAHVRRAAAEPPIPWQFDKRALAALTGPAGAAAPRGIER
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSTB_HUMAN
Sequence: MEHSEGAPGDPAGTVVPQELLEEMLWFFRVEDASPWNHSILALAAVVVIISMVLLGRSIQASRKEKMQPPEKETPEVLHLDEAKDHNSLNNLRETLLSEKPNLAQVELELKERDVLSVFLPDVPETES
What is the function of this protein?
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684).  Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:16317684).  The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684).  Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity).  Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684).  Able to transport eicosanoids such as prostaglandin E2 (By similarity).
What are the official names of this protein?
Organic solute transporter subunit beta, OST-beta, Solute carrier family 51 subunit beta.
What is the protein family that this protein belongs to?
Belongs to the OST-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.