PharMolix/UniProtQA huggingface dataset:
Protein: MEP8_ARTGP
Sequence: MRFSLSLIGLVASGSLAAAHPSHCGAEPSEDFDILSKDITDKLAAEASEIHAPIEVTTFFHVVASSKSVADGYISDKMLQDQLAVMNKAYAPHGFSFKHGNTTRTINPTWATGGDELNMKYALHMGKYADLNLYFVKKLADNSHGSCPYPSNPYPGTPGYIKDGCTILSSTVPGGSQSNANRGLTTVHEIGHYMGLYHTFQGGCSTELGDRVADTPAQKNGTVGCPSSRDSCPDQAGLDPIHNYMDTSDDVCRTEFTPKQAMRMQEMYKEFRAGK
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Plays a pivotal role as a pathogenicity determinant during infections and contributes to the ability of the pathogen to persist within the mammalian host (By similarity).
What are the official names of this protein?
Extracellular metalloprotease MGYG_03559.
What is the protein family that this protein belongs to?
Belongs to the peptidase M43B family.
What are the subcellular locations of this protein?
Secreted.
Protein: NAMA_BACC3
Sequence: MNSELFSPYTIKDVTLKNRIVMSPMCMYSSENEDGQVTNFHLIHYGTRAAGQVGLVMIEATAVLPEGRISNKDLGIWDDSLIEGLHKTTTFIHDNGAKAAIQLAHAGRKAELETDALAPSAVPFNETMKIPVEMSIQQIKNTILAFQQAAVRSKQAGFDVIEIHGAHGYLINEFLSPLSNKRTDEYGGSPEKRYRFLREIIDSINEVWNGPLFVRISANDYHPDGLTVQDYVQYTKWMKEQGVDLIDCSSGAVVPARIDVYPGYQVQYAKHIKEHANIATGAVGLITTGAQAEQILTNNEADLIFIGRELLRNPYFPRIAANELGFELEEPYQYERAPGKISTNK
What is the function of this protein?
Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones.  It also reduces the nitro group of nitroester and nitroaromatic compounds.  It could have a role in detoxification processes.
What are the official names of this protein?
NADPH dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.
Protein: YRDC_HUMAN
Sequence: MSPARRCRGMRAAVAASVGLSEGPAGSRSGRLFRPPSPAPAAPGARLLRLPGSGAVQAASPERAGWTEALRAAVAELRAGAVVAVPTDTLYGLACAASCSAALRAVYRLKGRSEAKPLAVCLGRVADVYRYCRVRVPEGLLKDLLPGPVTLVMERSEELNKDLNPFTPLVGIRIPDHAFMQDLAQMFEGPLALTSANLSSQASSLNVEEFQDLWPQLSLVIDGGQIGDGQSPECRLGSTVVDLSVPGKFGIIRPGCALESTTAILQQKYGLLPSHASYL
What is the function of this protein?
Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:29760464, PubMed:31481669, PubMed:34545459).  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate (PubMed:29760464).  Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (PubMed:29760464).  May regulate the activity of some transporters (By similarity).
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, Dopamine receptor-interacting protein 3, Ischemia/reperfusion-inducible protein homolog, hIRIP.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Cell membrane; Peripheral membrane protein. Note=A large fraction localizes in the cytoplasm, whereas a smaller fraction is imported to mitochondria.
Protein: PEX8_PICPA
Sequence: MYRLGSQGRSIQSQLQNGDSSSGRPLQLQGTGMREAQRIPQQLDYLLAEIISPNEDTNVIGYLAYYYPKLKNEQNVALLTDFFLRCPTYFSHSNVVSLRNNYPVMEAFNYIMTTKFKVSQPTVPFYRFYAAVLASLLNCEKTDPSHHWKLIPILTGVLLSIKGRDDVELYPDHSRSIKGSDTAVAQLLQRCLLRFYQSGDARSYDLNALVIISMSCALDYVEDDTIKKILYCFNYTRAIIDLIYYSPYGLNDSDIPLLSDSSVNSQSFDQLLNNNPALKHLNRLSFLFERTVKLNDGSIQSNLNDIDISLNKMQSFSEKLSKKISVLDDDSSKGVGQLLRQCLYASIIIHQAILTTFFQLDNADYTKYFLPSFSRKILSILFNLFFIVDRIGTGGFQPYNFVYLTCLQGIIQYDMKTAESLVKTFTTGINYSSLKDSEVARAKLLFTLNLMEQIVNICSDDLRLELIVPLVEDLVNNKNACVDIHNHVFKSIFESAHSVILKFFTVVDSSVKNVDYETNVTLVSEKIIPYLTLVIDQFPEFLSINQLDIAIETISRTVFPDSPIYSYDKNISSMFLNVLFNKCLTVDNDELVELPAIEAVVAPKNDEENNTSDAQDGGPKELQSLNDLKSRRSALISALISVFPLIPVKDYTKWLSIAFYDLIVATPERTERAFLQERLWDCVVGTNKYDPQKGNLGIMWWYENVNAQSTAKL
What is the function of this protein?
Essential component of the machinery required for the import of both PTS1 and PTS2 (and perhaps all) peroxisomal matrix proteins.
What are the official names of this protein?
Peroxisomal biogenesis factor 8, Peroxin-8, Peroxisomal protein PER3.
What are the subcellular locations of this protein?
Peroxisome matrix.
Protein: MER_METAC
Sequence: MKFGIEFVPSDPALKIAYYAKLSEQQGFDYVWITDHYNNRDVYSTLTVLALNTNSIKIGSGVTNSYTRNPAITASSIASIAEISGGRAVLGLGPGDKATFDAMGIAWEKPLATTKEAIQAIRDFIAGKKVSMDGEMVKFAGAKLAFKAGNVPIYMGAQGPKMLELAGEVADGVLINASHPKDFEVAVEQIRKGAEKVGRDPSEVDVTAYACFSIDKDPAKAINAAKVVVAFIVAGSPDLVLERHGIPVDAKKQIGDAIAKGDFGALMGGLVTPQMIEAFAICGTPEDCMKRIKDLEAIGVTQIVAGSPIGPEKEKAIKLIGKEIIAKM
What is the function of this protein?
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
What are the official names of this protein?
5,10-methylenetetrahydromethanopterin reductase, Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase, Methylene-H(4)MPT reductase.
What is the protein family that this protein belongs to?
Belongs to the mer family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHGBB_HUMAN
Sequence: MWDQRLVKLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEEHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKAILLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNAEKKGVYQTLSWKRYQPCWVLMVSVLLHHWKALKKVNMKLLVNIREREDNV
What is the function of this protein?
Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627, PubMed:33938018).  Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503).  Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation (PubMed:31883789).  Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development (PubMed:25721503, PubMed:27957544).
What are the official names of this protein?
Inactive Rho GTPase-activating protein 11B, Rho-type GTPase-activating protein 11B.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NU4LM_PROLO
Sequence: MSMVYVNISLAFTLSLMGLLMYRSHLMSSLLCLEGMMLSLFVMMSITIMSNHFTLASMAPIILLVFAACEAALGLSLLVMISNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PYRD_BRUA2
Sequence: MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGFAEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYLLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGIIVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYTGLIYRGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAARKLIS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FIMD_PORGN
Sequence: MRTNRILNIICPPILFLLVGFLFGCVREDIESDMNETSSLFLQVQPYNQRSEEGGVAAYDENTIERLTLVFYKNGTKVWQAEPVETSPSSNSYYVPVPESMYGQFNGNNSFKIYLVANVNFSGSFEPNASETSFLKTLVPNSILLQNDGKPEDKFAMIGSVEKQINMATSEGKQLGSIELKRVAAKLRLKKPVLNISDYELVGDPKAKFRNCMPKGFLSVEEKPEGVGYEAIDYRPMTEANSSVHFYSYYNEWALNNEGRPEFVMMLKLKKTGTDDNTAKPYYYRIPVDGSDKKIRSNHLYDMAVTIEVLGSLNEEDPVTINGSLSVIEWTSHSDDQTLPDVQYLEVIPQETVMNMTTEIELDYFSSHSLLPPADVKATCTYVNSNGQQITDTYTGANVPTVTIDANTKKIKVRSILPINNIPKDISFTIKNSIGFEKKIKIRQNPSQFIINTFGTKSSWQPEGNLAPNLNNKAIYQIVVLSPPADGNMIIGFPPTKEVGFYKKSGSSYTLKHTDRITEQDEQTANMVSPSFELASQLGATLVQDHWEYYTLNPLRLIYHSNQQNRYALMTCAFYWEERKKADGTIERLDDWRLPTRAEIQLVDKLQREQAGVVRDIMTGRYYWSGLPDKAIKILLPTASGNATEQRAHVRCVRDVKNDRFVKSAKRLKK
What is the function of this protein?
Probably a component of the fimbrium tip.  These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome.  They play an important role in invasion of periodontal tissues and are major virulence factors.  FimC, FimD and FimE contribute to interaction with host CXCR4 and thereby down-regulate the TLR2-mediated host immune response.
What are the official names of this protein?
Major fimbrium tip subunit FimD.
What is the protein family that this protein belongs to?
Belongs to the FimD family.
What are the subcellular locations of this protein?
Fimbrium. Cell outer membrane. Note=Probably synthesized as a palmitoylated precursor. Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide (Probable). Probably part of the fimbrium tip, as a part of the complex formed by FimC, FimD and FimE.
Protein: BIOF_ACIAC
Sequence: MTTFPFAPSWLDELPARLAELDAVHLRRRRRTVRPLQGAHLDVDGQPMLAFCSNDYLGLAGHPALADAACAGAREFGVGSGGSPLVSGHSQANAALEADLARFVQLPRALYFYAGYATNTGIVPALVGAGDALFSDALNHACLIDGARLSRATIHRYPHGDLAALEALLAASPARRKLVVSDAVFSMDGDVADIRTLHALCERHDALLLLDDAHGFGVLGPQGRGALAEAGLTGQRASQRVLYMATLGKAAGAAGAFVAGSEVLIEWLLQKTRSYIFATAAPALLARTLQASLGLIERGDALRAHLDARIAQLRAGLVPVLQGTHWELGTSRTAVQALVIGANDEALAAMEALRARGLWVPAIRPPTVPEGTARLRIALSAAHTEADVARLVDALADIAPTARSALPQEAAA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: COAE_WOLPM
Sequence: MIISLTGGIGVGKSFVANCFQEFGAVVFDADSVVHQLYKVDKSIISYAEKNFPGVVVNGEIDRTVLSKYFLAYDENWKQFQSLVHSAVLRELEFFIAKEKKIDRKLLVLDVPLLLETKFYLYCDLIVFVHADSVVQAQRLNERNIDKEKLNLISDVQLSIEEKRKMSDFIIDTSVSKEYVFSQVKDIVDSLNLNT
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT274_CONMO
Sequence: GNWCCSARVCC
What are the official names of this protein?
Conotoxin Mo1274.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BIOD_NOVAD
Sequence: MTAFVVTGTDTGVGKTIFSAALTGALNAHYWKPVQAGLEDGADRDHVARLAGVPASHVLPESYRLNTPCSPHRAAELDGVVLDLARIALPDVRPLVVEGAGGALVPVTRNTTYADVFAWWNLPVVIVARTGLGTINHSLLTIEALRARGVPIHGVAFVGDAVEDSEATICAMGEVRRLGRLPMLGQLDRPALAQAFAEGFRVEDFA
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPC_ARATH
Sequence: MADVSRSSSLYTEEDPLQAYSGLSLFPRTLKSLSNPLPPSYQSEDLQQTHTLLQSMPFEIQSEHQEQAKAILEDVDVDVQLNPIPNKRERRPGLDRKRKSFSLHLTTSQPPPVAPSFDPSKYPRSEDFFAAYDKFELANREWQKQTGSSVIDIQENPPSRRPRRPGIPGRKRRPFKESFTDSYFTDVINLEASEKEIPIASEQSLESATAAHVTTVDREVDDSTVDTDKDLNNVLKDLLACSREELEGDGAIKLLEERLQIKSFNIEKFSIPEFQDVRKMNLKASGSNPPNRKSLSDIQNILKGTNRVAVRKNSHSPSPQTIKHFSSPNPPVDQFSFPDIHNLLPGDQQPSEVNVQPIAKDIPNTSPTNVGTVDVASPFNDSVVKRSGEDDSHIHSGIHRSHLSRDGNPDICVMDSISNRSSAMLQKNVDMRTKGKEVDVPMSESGANRNTGDRENDAEINEETDNLERLAECASKEVTRPFTVEEDSIPYQQGASSKSPNRAPEQYNTMGGSLEHAEHNQGLHEEENVNTGSASGLQVENAPEVHKYSHKQTNKRRKRGSSDSNVKKRSKTVHGETGGDKQMKTLPHESRAKKQTKGKSNEREEKKPKKTLTHEGKLFSCRKSLAAAGTKIEGGVRRSTRIKSRPLEYWRGERFLYGRIHESLTTVIGIKYASPGEGKRDSRASKVKSFVSDEYKKLVDFAALH
What is the function of this protein?
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
What are the official names of this protein?
Centromere protein C, AtCENP-C, CENP-C, CENP-C homolog.
What is the protein family that this protein belongs to?
Belongs to the CENP-C/MIF2 family.
What are the subcellular locations of this protein?
Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus. Note=Present at the centromeric regions, especially in the kinetochore domain, throughout the cell cycle.
Protein: SSTT_PHOLL
Sequence: MEKQKRGFVHYIVQGSLVKQILVGLIAGILLAWLAPSVAKSVSLLGTLFVGALKAVAPVLVWILVMSSIANHKKGQKTNIRPILILYILGTFFAALVAVAGSFIFPLPLVLAVNDAQMSPPENIIEVIKGLLVNVVANPVNALLNGNYIGILAWAIGLGIALRHAADSTKSLIHDMSEAVTQVVRVVIRFAPVGIFGLVSATIAETGFNALLGYVQLLVVLLSCMLVMALVVNPLIVYWKIRRNPYPLVFACLRESGVTAFFTRSSAANIPVNMAMCRRMNLHEDTYSVSIPLGATINMEGAAVTIPVLTLAAVNTLGIPVDVPTALLLSVVSAICACGASGVAGGSLLLIPLACSMFGISNEIAMQVVAVGLIIGVLQDSAETSLNSSTDVLFTAAVCQAEDDRLSSDQLTQRN
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIBA_ACIAD
Sequence: MAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFNEQYLKTKKERMAHLYQKDDF
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: PLCB3_MOUSE
Sequence: MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDEFPLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYETNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAEAAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLSAGIPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGEESLSREPNVPMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDKKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTETYQETPCQQPGSQLPSNPTPNPLDASPRWPPGPTTSSTSSSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSPSALGKATNSEDVKEEEEAKQYREFQNRQVQSLLELREAQADVETKRKLEHLRQAHQRLKEVVLDTHTTQFKRLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERLVAGQQQVLQQLEEEEPKLLAQLTQECQEQRERLPQEIRRCLLGETAEGLGDGPLVACASNGHAPGSGGHLSSADSESQEENTQL
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Nucleus. Note=And particulate fractions.
Protein: TNPO3_MOUSE
Sequence: MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHSIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANSSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMSQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR
What is the function of this protein?
Importin, which transports target proteins into the nucleus.  Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains.  Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation.  The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively.  Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.
What are the official names of this protein?
Transportin-3.
What are the subcellular locations of this protein?
Nucleus envelope. Cytoplasm. Note=Localizes to the nuclear envelope and annulate lamellae, which consists in stacks of endoplasmic reticulum membranes containing a high density of nuclear pores.
Protein: MPC1_DICDI
Sequence: MAERWTKMVGFLGAAANWTIPIASFMNLKNDPEKVDPIMTTTLAVYSAVFMRWAIAIYPPNYWLLGCHVANEVAQLTQLGRYGKWKVFDSKQESDKQ
What is the function of this protein?
May mediate the uptake of pyruvate into mitochondria.
What are the official names of this protein?
Probable mitochondrial pyruvate carrier 1, MPC1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EFP_CHRVO
Sequence: MKTAQELRAGNVFMVGSDPMVVQKAEFSKSGRNASVVKMKMKNLLTGAGSEAVYRADDKFDVVVLDRKDCTYSYFADPMYVFMDTEFNQYEVEADNLGDTINYIVDGMEDVCQVTFYDGKAISVELPTTVIREVEYTEPAVRGDTSGKVLKPARLVGTTFEVQVPAFVNTGEKIEIDTRTNEFKKRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAGK_STAA1
Sequence: MRKRARIIYNPTSGKELFKRELPDALIKLEKAGYETSAYATEKIGDATLEAERAMHENYDVLIAAGGDGTLNEVVNGIAEKPNRPKLGVIPMGTVNDFGRALHIPNDIMGALDVIIEGHSTKVDIGKMNNRYFINLAAGGQLTQVSYETPSKLKSIVGPFAYYIKGFEMLPQMKAVDLRIEYDGNVFQGEALLFFLGLTNSMAGFEKLVPDAKLDDGYFTLIIVEKSNLAELGHIMTLASRGEHTKHPKVIYEKAKAINISSFTDLQLNVDGEYGGKLPANFLNLERHIDVFAPNDIVNEELINNDHVDDNLIEE
What is the function of this protein?
Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid.  Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway.
What are the official names of this protein?
Diacylglycerol kinase, DAG kinase, DAGK.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family.
Protein: YFM4_YEAST
Sequence: MLFAYSGCLAPQCIPDISSFKALPFRDTESRFTTDSSVISSRFSSSFTSSSSKIIIITSIFSSKMDNEHVGASLIVSLSMASLILTNVFSFSSTSYSSQPSDYIACSPSGIDDQPVAEPSGYTPVGSSSPHSGCITSGLDAIGYQSSLNEGQSTNASSRFVTKVYSHSALTHIILHLLSILQKFYLQVSTIS
What are the official names of this protein?
Uncharacterized protein YFR054C.
Protein: RL332_LIMRJ
Sequence: MRVNITLECTSCHERTYLTSKNRRHNPDRLELNKYCPREQKVTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: TAL_CHLAB
Sequence: MSSQFEQLKLLSVLVCDTGDPELVKSSESQDATTNPSLILKVAQEPKYQELLTEAIAWGIRQNGDDVQTLTFVLDKIQVNFGLEILKHIPGRVSLEIDARLSFNTEAMVQRAIFLSELFAASGGDKKRLLVKIPGTWEGIQAVELLEKQGIACNVTLIFNLIQAIAAAKAKATLISPFVGRIYDWWIAAYGDDGYSIDADPGVASVSNIYTYYKKFDITTQIMAASFRSKEQVLALAGCDLLTVSPKLLDELKKDQSPVERKLDPAEAKKLDVQPVELTESIFRFLMNEDAMATEKLAEGIRIFSGDTQILEAAVTEFIKQIAAQDV
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPB9_ASHGO
Sequence: MTTFRFCRDCNNMLYPREDKEEQRLLFECRTCTYAEEAGTPLVYRHELITNIGETAGVVQDIGSDPTLPRSDRECPRCHSHDNVFFQSQQRRRDTSMVLFFVCLGCSHIFTSDQKNKRTTFS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template.  Involved in the regulation of transcription elongation (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB9, RNA polymerase II subunit B9, DNA-directed RNA polymerase II subunit 9.
What is the protein family that this protein belongs to?
Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.