PharMolix/UniProtQA huggingface dataset:
Protein: ICP47_CHV1E
Sequence: MSSRYLAAVDDYLHHPSPRYQAHVDLRRELRAYADEERREAARAIAHPERPLLPPPATQAAPPQPSTREAAHPSAPTAASS
What is the function of this protein?
Plays a role in the inhibition of host immune response.  Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules.  Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation.  In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
What are the official names of this protein?
ICP47 protein, Immediate-early protein IE12, Immediate-early-5, Infected cell protein 47, US12 protein, Vmw12.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US12 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: GUNY_DICD3
Sequence: MGKPMWRCWALMLMVWFSASATAANGWEIYKSRFMTTDGRIQDTGNKNVSHTEGQGFAMLMAVHYDDRIAFDNLWNWTQSHLRNTTSGLFYWRYDPSAANPVVDKNNASDGDVLIAWALLKAGNKWQDNRYLQASDSIQKAIIASNIIQFAGRTVMLPGAYGFNKNSYVILNPSYFLFPAWRDFANRSHLQVWRQLIDDSLSLVGEMRFGQVGLPTDWAALNADGSMAPATAWPSRFSYDAIRIPLYLYWYDAKTTALVPFQLYWRNYPRLTTPAWVDVLSSNTATYNMQGGLLAVRDLTMGNLDGLSDLPGASEDYYSSSLRLLVMLARGK
What is the function of this protein?
Represents only 3% of the global cellulase activity.
What are the official names of this protein?
Minor endoglucanase Y, Cellulase Y, Endo-1,4-beta-glucanase Y, EGY.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 8 (cellulase D) family.
Protein: UGPA_SHIF8
Sequence: MSSSRPVFRSRWLPYLLVAPQLIITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLDNFVTLFHDSYYLDSFWTTIKFSTFVTVSGLLVSLFFAALVEYIVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLFFYAALQSIPRSLIEAAAIDGAGPIRRFFKIALPLIAPVSFFLLVVNLVYAFFDTFPVIDAATSGGPVQATTTLIYKIYREGFTGLDLASSAAQSMVLMFLVIVLTVVQFRYVESKVRYQ
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpA.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AAAT_MOUSE
Sequence: MAVDPPKADPKGVAVDSSRRCPALGSREDQSAKAGGCCGSRDRVRRCIRANLLVLLTVAAVVAGVGLGLGVSAAGGADALGPARLTRFAFPGELLLRLLKMIILPLVVCSLIGGAASLDPSALGRVGAWALLFFLVTTLLASALGVGLALALKPGAAVTAITSINDSVVDPCARSAPTKEALDSFLDLVRNIFPSNLVSAAFRSFATSYEPKDNSCKIPQSCIQREINSTMVQLLCEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPVGILFLVASKIVEMKDVRQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNEVSLNPLPLATEEGNPLLKQYQGPTGDSSATFEKESVM
What is the function of this protein?
Sodium-coupled antiporter of neutral amino acids.  In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity) (PubMed:7702599, PubMed:8662767).  The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation.  Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way.  Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (By similarity).  The transport cycle is usually pH-independent, with the exception of L-glutamate.  Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion.  May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (By similarity).  Can transport D-amino acids.  Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (By similarity).  Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity).  Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (By similarity).
What are the official names of this protein?
Neutral amino acid transporter B(0), ATB(0), ASC-like Na(+)-dependent neutral amino acid transporter ASCT2, Insulin-activated amino acid transporter, Sodium-dependent neutral amino acid transporter type 2, Solute carrier family 1 member 5.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Melanosome.
Protein: CYST_CHLVU
Sequence: MKRYPTFIKNSILLFYFFFLLILPVVVLFLLIFQNNWHEVLRKATDPIAVSAYLLTVQMAFYAALVNSIFGFIITWVLTRYQFWGREFLDAAVDLPFALPTSVAGLTLATVYGDQGWIGSLFNLFGFQIVFTKIGVLLAMIFVSFPFVIRTLQPVLQEMEKSLEEAAWSLGASSWETFRKVILPTLWPALFTGFTLSFSRALGEFGSIVMISSNLPFKDLVASVLIYQSLEQYDYLGASVIGAVVLLIALFTLLLINAFQIMKFRV
What is the function of this protein?
Part of the ABC transporter complex cysAWTP (TC 3. A. 1. 6. 1) involved in sulfate/thiosulfate import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Probable sulfate transport system permease protein cysT.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: RECA_STRPJ
Sequence: MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGERAEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETTPGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMYGEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQVRSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCAR_SALEP
Sequence: MDHRLLEIIACPVCNGKLWYNQEQQELICKLDNLAFPLRDGIPVLLENEARALTSDESKS
What are the official names of this protein?
UPF0434 protein YcaR.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: RL31B_SALPC
Sequence: MKPDIHPVYRTVVFHDTSANEYVKVGSTIKTEREIELDGVTYPYVTIDVSSKSHPFYTGRQKTFDSESSAARFQKRFGHFIGAKRG
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: NKAI4_XENLA
Sequence: MACCTGRCTLILLCTLQLVAALERQVFDFLGYQWGPILANFLHIVVTILGLFGTLQYRPRYVIAYAIWAAIWVTWNVFLICFYLEVGDLNKESDLLSFHVSQHQSWWSEHGPGCVRKEAPVAGVAGLESHSYVSVIGCSVEYQYIEVMHSALQILLALLGFVYACYVTSVFTEEEDSFDFIGGFDPFPLYHVNEKSNHLLVKQTSLPA
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4, Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4.
What is the protein family that this protein belongs to?
Belongs to the NKAIN family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YG03_SCHPO
Sequence: MGAILSTPKTPIEVRRKRIVPLFRANHTRFRPVDEKNRINAVPLLLLGCLYGKYKDDDFVDFFDKAIPLLVPQTHKGLDTYEIDVSTYKTHIGHPKFIEPFVLFYGDRLVHDARYNLHELVWQTLSRNPEYIKGLCYDSCTPLANLAVGLSLNIQEVLIDCFATAACFTTEDTSINPIPTLPSVFCTIVDDEGISLKELLYIIEESLLKNAIPDPFSVSTYTLKSAFEHLVKKDFLKYYTAYLASSAVDYIDAYFTESFGSFFISRLASQFLVSFQTLPSFFSFPLVTDNWQHLAALPFNSTYETFRAFDHPSTNGPAIGPLYNAAPAPR
What are the official names of this protein?
Uncharacterized protein C1604.03c.
Protein: TSAD_NOCFA
Sequence: MGIESSCDETGVGIVRWHPDGTCELLADEVASSVDQHARFGGVVPEIASRAHLEAIVPAMRRALSAAGIAKPDALAVTIGPGLAGALLVGVAAAKAYAAAWDVPFYALNHLGGHVAVDTLEHGPMPPCVALLVSGGHTHLLHVTDLAAPIVELGSTVDDAAGEAFDKVARLLGLGFPGGPALDAAARDGDPHAIAFPRGMTGPRDPRYDFSFSGLKTAVARHVEAAQRAGVAIADLPIPDIAASFQEAVADVLTMKAVRAAQDMGVDTLVLGGGATANSRIRSLAEERCAAAGLTLRVPKPRLCTDNGVMIAALGAHVIAGGARPSPLTVASDPGLPVSVSQIA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2AV_PAGMA
Sequence: MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA
What is the function of this protein?
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  May be involved in the formation of constitutive heterochromatin.  May be required for chromosome segregation during cell division (By similarity).
What are the official names of this protein?
Histone H2A.V, H2A.F/Z.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
Protein: GPDA_ROSDO
Sequence: MSVGILGAGAFGTALAISLGHTTPVTLWARDAKQAQVMQNTRENTARLPGFALPAGVKVTSNLADLQGCDVLLLAVPAQKLRQFLRGLDQMVAGKTLVTCCKGIELETGMGPVDIAREICPQSEHAILTGPSFANDIAKGLPTALTLACANPDRARQLQQELSNGTLRLYRTSDVIGAQLGGALKNVIAIACGAAIGAQLGESARAALMTRGNAEMQRYAQHKGADASTLSGLSGFGDLVLTCTSELSRNYRFGLALGAGKAFDPATTVEGAATACAVAQEAREKALDMPISSVVAALVENRLDVENAMTKLLSRSLKEE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB_METAR
Sequence: MMEDKQYKGTTTIGIICDQGVVLATERRATMGNFIASRDAQKIYRITDNAAMTIAGSVGDGQRLARILQVEAKLFELRRHGSMSINALSMLLSNILAEMRYAPYYVQVLIGGLDKAGPKIYSLDPLGGRIEEEKFVSTGSGSPIAYGVLEDRYKPGMSVEEGVELAARALESAMKRDSASGNGMQFCVITAEKFEIFEREVSKQVINA
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PsmB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_FRATO
Sequence: MLTKRFYNLAIMQDISNHTPMIQQYLKIKSQYQDILLFYRMGDFYELFFDDAKKAAELLDITLTARGKSNGESIPMAGVPYHAAEAYIAKIVKKGLSIAICEQTGDPNTSKGPVERQVTRIITPATVSEEAFLDNNQDSILVSIFEKNNKYYLAYTSYTQGKIYLVKTLTSLNELKNTVLKLSPQEIITNSRELAQQNPFKKPIKALEEWYYSNFEAKKYINDSLDTNIANNILNLYKNDQLTTIGSILSYLTNILKDTPRHITDISYEQEQDTLNIDINSRINLELDNNSKSSLLSIIGKCKTSLGSRLLKRYFSNPTRNLNILATRHSIINSLGENQHFLKIQDVLSYISDIERIISRVALGTVKPKDLVALRYSLEQLPILKKLLSEKNTPEITNINNRIHQLDELVTLLDKAIIENPPTTIRDGGVIKEGFDKELDELKSIKDNSYDFLIKFEELQKQKIGISTLKVGYNRVHGYYIELSKQHADKIPTEYVRRQTLKASERYITEELKNFEDKVLSSKEKALAREKLIYDTLLKKVIEYYKQIQETAASIAEIDVLANFAERAIKLKLSQPKFNNLAKLELKEVRHLAIEHNIDEPFIPNDTLLSKDTNTLQIITGPNMGGKSTYMRQVAQLIFLAYIGSFVPASYADICDIDTIYTRIGASDDISSGRSTFMVEMTETAYILNNASAKSLVIMDEIGRGTSTFDGLALAKACAEKFAQMGAFTLFATHYFELTELAKQYPNVCNIHFEAKEYKDNIYFMHKAVTGAAKKSYGIQVAKLAGISQDVLESAKQNLYNLEKKQQLTESTQVQAQFQLEPTTQNPLQQKLDAIDINTITPLEALNILFELKKR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: GCS2_ECO57
Sequence: MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNKITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAAADHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHKEKDYLLYKFNRFQACRYGLEGVITDPYTGDRRPLTEDTLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: RL32_MYCTO
Sequence: MAVPKRRKSRSNTRSRRSQWKAAKTELVGVTVAGHAHKVPRRLLKAARLGLIDFDKR
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: AMYR_DROEC
Sequence: MFKFASAVILCLVAASSTQAQHNPHWWGNRNTIVHLFEWKWSDIAAECENFLGPQGFAGVQVSPVNENIISPGRPWWERYQPISYKLTTRSGDEQEFGDMVRRCNDVGIRIYVDVLLNHMSGDFDGIALGTAGSETEPSTKSFPGVPYTAQDFHPSCEITDWNDRFQVQQCELVGLKDLDQSSDWVRSKLIEFLDHLIELGVAGFRVDAAKHMAADDLSYIYSSLSDLNIEHGFPHNARPFIFQEVIDHGHETVSRDEYNQLGAVTEFRFSEEIGNAFRGNNALKWLQSWGTGWGFLPSGQALTFVDNHDNQRDMGAVLNYKSPKQYKMATAFHLAYPYGISRVMSSFAFDDHDTAPPQDEQEKIISPEFDEEGGCVNGWICEHRWRQIYAMVGFKNAVRDTEISDWWDNGDNQISFCRGNKGFLAVNNNLYDLSQELQTCLPAGVYCDVISGSLVDGSCTGKSVTVDNNGYGYIHIGSDEFDGALALHVDAKI
What are the official names of this protein?
Alpha-amylase-related protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS18_BIFAA
Sequence: MSRKRPQPPVKPFKKKPNPLKAAKVTEIDYKDVALLRKFISDRGKIRSRRITGVTVQEQREISKAIKNAREMALLPYATSGR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: CDR1_CANAL
Sequence: MSDSKMSSQDESKLEKAISQDSSSENHSINEYHGFDAHTSENIQNLARTFTHDSFKDDSSAGLLKYLTHMSEVPGVNPYEHEEINNDQLNPDSENFNAKFWVKNLRKLFESDPEYYKPSKLGIGYRNLRAYGVANDSDYQPTVTNALWKLATEGFRHFQKDDDSRYFDILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERHYRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYAKHMASVYMATYGLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALKTSAVILDTTPLIAIYQCSQDAYDLFDKVVVLYEGYQIFFGKATKAKEYFEKMGWKCPQRQTTADFLTSLTNPAEREPLPGYEDKVPRTAQEFETYWKNSPEYAELTKEIDEYFVECERSNTRETYRESHVAKQSNNTRPASPYTVSFFMQVRYGVARNFLRMKGDPSIPIFSVFGQLVMGLILSSVFYNLSQTTGSFYYRGAAMFFAVLFNAFSSLLEIMSLFEARPIVEKHKKYALYRPSADALASIISELPVKLAMSMSFNFVFYFMVNFRRNPGRFFFYWLMCIWCTFVMSHLFRSIGAVSTSISGAMTPATVLLLAMVIYTGFVIPTPSMLGWSRWINYINPVGYVFESLMVNEFHGREFQCAQYVPSGPGYENISRSNQVCTAVGSVPGNEMVSGTNYLAGAYQYYNSHKWRNLGITIGFAVFFLAIYIALTEFNKGAMQKGEIVLFLKGSLKKHKRKTAASNKGDIEAGPVAGKLDYQDEAEAVNNEKFTEKGSTGSVDFPENREIFFWRDLTYQVKIKKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVTTGIITDGERLVNGHALDSSFQRSIGYVQQQDVHLETTTVREALQFSAYLRQSNKISKKEKDDYVDYVIDLLEMTDYADALVGVAGEGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQAILCTIHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMINYFEKYGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEVWRNSSEYQAVREEINRMEAELSKLPRDNDPEALLKYAAPLWKQYLLVSWRTIVQDWRSPGYIYSKIFLVVSAALFNGFSFFKAKNNMQGLQNQMFSVFMFFIPFNTLVQQMLPYFVKQRDVYEVREAPSRTFSWFAFIAGQITSEIPYQVAVGTIAFFCWYYPLGLYNNATPTDSVNPRGVLMWMLVTAFYVYTATMGQLCMSFSELADNAANLATLLFTMCLNFCGVLAGPDVLPGFWIFMYRCNPFTYLVQAMLSTGLANTFVKCAEREYVSVKPPNGESCSTYLDPYIKFAGGYFETRNDGSCAFCQMSSTNTFLKSVNSLYSERWRNFGIFIAFIAINIILTVIFYWLARVPKGNREKKNKK
What is the function of this protein?
Pleiotropic ABC efflux transporter that confers resistance to numerous chemicals including anisomycin, cycloheximide, fluconazole, miconazole, ketoconazole, itriconazole, nystatin, terbinafine, amorolfine, brefeldin A, amphotericin B, fluphenazine, as well as estrogen.  Plays a role in farnesol-induced apoptotic process through glutathione efflux activity.  Mediates in-to-out translocation of membrane phospholipids including aminophospholipids and thus regulates asymmetric distribution of phosphatidylethanolamine.  Exhibits nucleoside triphosphatase activity.
What are the official names of this protein?
Pleiotropic ABC efflux transporter of multiple drugs CDR1, Pleiotropic drug resistance protein CDR1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Accumulates at membrane rafts. Both ergosterol and sphingolipids are essential for targeting to membrane rafts. Mislocalizes to the vacuole in absence of FZO1.
Protein: NU1M_PISOC
Sequence: MSVILLLLNSIGFIVPVLLAVALLTLIERKVLGYMQLRKGPNIVGPYGLLQPIADGFKLIIKETLKPSNASPYLFYLSPVLFFFLSILLWSIIPVINSTLNFNLSLILILGLSSLSVYSLLGSGWSSNSNYSFLGGVRAVAQTISYEISLGLILLSVVVFSGGFNIGLISSVQNECWLAVCCFPLFSIWFISTLAETNRAPFDLTEGESSNSFQGTMLNIPGGPFALFFIAEYANIIFMNLFSVLLFLGGGSPVNLLFPINIISVIFKTVALVVLFLWIRASYPRFRYDQLMYLTWKKYLPLSLGLLIFFKFLLSLNKDYLQDY
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: URE1_STRT1
Sequence: MSFKMDREEYAQHYGPTVGDSVRLGDTNLFAAIEKDFTVYGQESKFGGGKVLRDGMGVSATETRDNPSVVDTIITGATIIDYTGIIKADIGIRDGKIVAIGRGGNPDTMDNVDFVVGASTEAIAAEGLIVTAGGIDLHVHYISADLPEFGMDNGITTLFGGGTGPADGSNATTCTPGKFHITRMLQAVDDMPANFGFLAKGVGSETEVVEEQIKAGAAGIKTHEDWGATYAGIDNSLKVADKYDVSFAVHTDSLNEGGFMENTLESFQGRTVHTFHTEGSGGGHAPDIMVFAGKENILPSSTNPTNPYTTNAIGELLDMVMVCHHLDPKIPEDVSFAESRVRKQTVAAEDVLHDMGALSIMTSDAMAMGRVGEVVMRCWQLADKMKAQRGPLEGDSEFNDNNRIKRYVAKYTINPAITNGIADYIGSVEVGKFADLVIWEPAQFGAKPKLVLKGGMLTYGVMGDAGSSLPTPQPRIMRKLYGAYGQAVHKTNITFVSQYAYDHGIKEEIGLNKIVLPVKNTRNLTKRDMKLNDYAPKTIRIDPQTFDVFIDDELVTCEPIHTTSLSQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMB_RAT
Sequence: MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAEREEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPMPQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMGRGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGLL
What is the function of this protein?
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).  Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).  As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
What are the official names of this protein?
Small nuclear ribonucleoprotein-associated protein B, snRNP-B, snRPB, SM11, Sm protein B, Sm-B, SmB.
What is the protein family that this protein belongs to?
Belongs to the snRNP SmB/SmN family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Protein: GPMA_LACLS
Sequence: MPKLVFARHGESEWNLANLFTGWADVDLSENGTKQAIEAGKLIKEAGIEFDIAYTSVLKRAIKTTNLALEFSDQLWVPVVKSWRLNERHYGGLTGLNKADAAAKHGDEQVHIWRRSYDVLPPAMDHDDKYTAHGDRRYAGLEDSLIPDAENLKVTLERALPFWEDQIAPALKEGKNVFVGAHGNSIRALVKQIKKLSDDEIMDVEIPNFPPLVFEFDDNLNVQNEYYLAPKKA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: QUEF_ACIF5
Sequence: MPSQPSRELERFSNPHPERDYVVHMDLPEFTCLCPLTGQPDFAHFMLDFIPDQHNVELKSLKLYLWSFRDEGAFHEAMTNRIADDLIGLINPRYLRLLGRWYVRGGITTDVLIEHRQPGWQNPDILGQLPTVRWAQHQPGH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.