PharMolix/UniProtQA huggingface dataset:
Protein: FUS_SENDH
Sequence: MTAYIQRSQCISTSLLVVLTTLVSCQIPRDRLSNIGVIVDEGKSLKIAGSHESRYIVLSLVPGVDLENGCGTAQVIQYKSLLNRLLIPLRDALDLQEALITVTNDTTQNAGVPQSRFFGAVIGTIALGVATSAQITAGIALAEAREAKRDIALIKESMTKTHKSVELLQNAVGEQILALKTLQDFVNDEIKPAISELGCETAALRLGIKLTQHYFGLLTAFGSNFGTIGEKSRTLQALSSLYSANITEIMTTIRTGQSNIYDVIYTEQIKGTVIDVDLERYMVTLSVKIPILSEVPGVLIHKASSISYNIDGEEWYVTVPSHILSRASFLGGADITDCVESRLTYICPRDPAQLIPDSQQKCILGDTTRCPVTKVVDSLIPKFAFVNGGVVANRIASTCTCGTGRRPISQDRSKGVAFLTHDNCGLIGVNGVELYANRRGHDATWGVQNLTVGPAIAIRPVDISLNLADATNFLQDSKAELEKARKILSEVGRWYNSRETVITIIVVMVVILVVIIVIVIVLYRLKRSMLMGNPDERIPRDTYTLEPKIRHMYTNGGFDAMAEKR
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) interacts with HN tetramer at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0, Protein F.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: MET3_ASPNG
Sequence: MANTPHGGVLKDLLARDAPRHDQLAAEAEILPALTLTERQLCDLELIMNGGFSPLEGFMNQKDFDGVCENCRLADGNVFSMPITLDASQKTISELKLQAGSRLTLRDFRDDRNLAILTIDDIYRADKQKEAKLVFGGDPEHPAIKYLNNTVQEFYIGGKIEAVNKLNHYDYVALRYTPAELRVHFDKLGWSRVVAFQTRNPMHRAHRELTVRAARARQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPRYPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGKNSKGEEFYGPYDAQHAVEKYKDELGIEVVEFQQVTYLPDTDEYRPKDEVPAGVKTLDISGTELRKRLRTGAHIPEWFSYPEVVKILRESNPPRASQGFTIFLTGYMNSGKDAIARALQVTLNQQGGRSVTLLLGDTVRHELSSELGFSREDRHTNIQRIAFVAGELTRAGAAVIAAPIAPYEESRKAAREAVAGSGGNFFLVHVATPLEHCEKTDKRGIYAKARRGEIKGFTGVDDPYEAPANADLTVDVSKQSVRSIVHEIILMLESEGYFERL
What is the function of this protein?
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.  Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the APS kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIBS_BPP1
Sequence: MNDVTVVTSVTYPSSESLALVADVQYHEPYLSAALNRKFRGIVDPGFYAGFLPKPGGGMNLLITSVDGDKTAGAASVDIGEFYQVTIQQRKDISLALSAGKKYAIVLKGRYLLGEDTYQVNTASHIHAAEFVARTYTDSYQLGDGELLVCTVNIPASVSAITQEMIDTSERINRSIGIDISDSVTSTRSDVAASSLAVKKAYDLAKSKYTAQDASTTQKGLVQLSSATNSDSETMAATPKAVKSIKD
What are the official names of this protein?
Major tail fiber protein S.
What is the protein family that this protein belongs to?
Belongs to the tail fiber family.
What are the subcellular locations of this protein?
Virion.
Protein: NU4C3_TRIV2
Sequence: MNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQSSTYQFVEKYHWLPQIGLNWSVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLMLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGGPKRRYAATKFILYTAAASIFILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAHGEASAPGSMILAGVLLKMGGYALIRFNIEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQTNLKRRLAYSSIAHMGFVLIGLASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTLLMDKMGGIGKVMPKTFALYTAGAMASLALPGMSGFVGELMVFIGIATSDVYSSSFKVVVVLLSAVGVILTPIYLLSLLRQVFYGKQSEELHLDAFIPDVKPRELFITASLLLPIIGIGLYPKLITQTYDVKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAEVESLVNISK
What is the function of this protein?
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4 3, NAD(P)H dehydrogenase I, chain 4 3, NDH-1, chain 4 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: LPXD_PSYIN
Sequence: MVYNLGQLAQQLNAQLVGDAELNIYRLATFEKAAQGDITFVSDKNLLTRLDECNASAIVLPNSFKQGYQGNALFMETPYVGYALLARIFDTTPNPQPAIAASAQIHKNAIIGQNVTIAHNVVIEEGVVIGDNCQIMDNVVIGQYSTLGENTRIYPNATLYHQTELGKRCIIHANAVIGSDGFGNAPYQGTWIKIPQIGKVIIGDDVEIGASTTIDRGGLSDTLIANGVKIDNQCQIAHNVSIGAHTAIAGGSNVAGSTKIGSNCIVGGCVAINGHITIVDNVVVTGDSMVMRSITEPGIYSSGVPAQKNKAWRKTTAHTLKIDDLFKRVKALEKQLKDNT
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: YD183_YEAST
Sequence: MIRSIFIPPTSITATSRLFYGMRAYSTKLEKASLQKYLHDPVKVTVIPITDKESFIYYKHTDNLFNSQSRILKAEKWIVEKSAKLWRKLKKSPKSYNKKIVSMVQSLLNSTPWSENSLLTIPSESYILKRIKGEKDKTQEIRLTLKDYTVKAEQVDTQPLHVYYPPGISSPDECLRQMKKLYQEGLIYHKKWTLYCLLGLPLTIPLILIPLIPNVPGFYLSYRAYVNIKAYLGAKHLKSLLESSKQNLEFRELLGYTEVYKRGTSSRTQGNQKESKGAPELLLNKKTLPLILDFLEVHELESDLNKVILQESKSQEKNKI
What are the official names of this protein?
Uncharacterized protein YDL183C.
What is the protein family that this protein belongs to?
To S.pombe SpAC23H3.12c.
Protein: DNJB8_HUMAN
Sequence: MANYYEVLGVQASASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKLVSEAYEVLSDSKKRSLYDRAGCDSWRAGGGASTPYHSPFDTGYTFRNPEDIFREFFGGLDPFSFEFWDSPFNSDRGGRGHGLRGAFSAGFGEFPAFMEAFSSFNMLGCSGGSHTTFSSTSFGGSSSGSSGFKSVMSSTEMINGHKVTTKRIVENGQERVEVEEDGQLKSVTVNGKEQLKWMDSK
What is the function of this protein?
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
What are the official names of this protein?
DnaJ homolog subfamily B member 8.
Protein: SYFB_CUTAK
Sequence: MKVPMSWLQAMVNLPDGTTTDKVAKALTNHTATVEKVEVVGGELTGPIVIGHILSSVPEPQKNGKVINWCRVDVGPRYNAEGHPKNIEEGVEGRGIICGAPNAVEGAWVVVSLPGAVLPGGFAISARKTYGHMSDGMLCASDELGIGVDDAGIITLPPSVEGHQLVPGEDALPILGVPEEVLDVDVTPDIGYCMSMRGIAREVAHAMSVHFRDPYDEEPIGPVLGPVAVDVQSDACSQFIALPVSGMNLGAPTPRFITDRITRAGMRPINLVVDVTNYVMLESGQPLHAYDADNVSGTIVVRKAHEGEHLLTLDDTDRTLDPDDLVIADDSGAIGLAGVMGGAATEVTAETTSIILEGAHFDPMTVARAYRRHKLGSEASRRFERGVDPICAHTAAVRAAELLAQYGGATVGEPTVVGEVPEMPRQTINADLPNRILGTKVPTEEVIEILTRSGVKVTALGDSLHLVAPTWRPDLVDAYDYVEEIGRKIGFDRIKAVLPPSLGASGLTKAQRGRRRVLRSVVEAGFVELITLPFIGDKDLDVLGISGDDTRHATVKLANPLDDTRPYLRTTLLPGLFHAVTTNMSRSQDDLAVFESGTVFRAVTPAAAPRPGVDERPSDEVLAEIDAALPAQPRMLAAVICGSWLPDRWDGESVKADWRHAVLVAQKAADALGVRLVRKADRQAPWHPGRCAALIVDGKVIGHAGELHPTVVSKAGLPQRTCAVEFNLDALVAAAPRGGEVMAISSFPVAKEDVALVVDKSVAAEDVRQALIEGAGPLLESIELFDVYEGEQVGDNRKSLAFNLRLRGADRTLTDSEALETRDAAVARAEETCGAQLRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C6A14_DROME
Sequence: MLFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKVERV
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 6a14, CYPVIA14.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: YFIA_ECOLI
Sequence: MTMNITSKQMEITPAIRQHVADRLAKLEKWQTHLINPHIILSKEPQGFVADATINTPNGVLVASGKHEDMYTAINELINKLERQLNKLQHKGEARRAATSVKDANFVEEVEEE
What is the function of this protein?
During stationary phase prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases (PubMed:16324148).  During environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation elongation and increases translation accuracy (PubMed:11375931, PubMed:15219834).  When normal growth conditions are restored, is quickly released from the ribosome (PubMed:11375931).  Has been suggested to inhibit translation elongation by blocking the A-site (aminoacyl-tRNA site) (PubMed:11375931).  Has also been suggested to inhibit translation initiation by blocking the A-site and P-site (peptidyl-tRNA site) of the ribosome (PubMed:15502846, PubMed:23420694).  At 15 degrees Celsius binds 30S subunits and stimulates their association with 50S subunits into idle 70S ribosomes (PubMed:23420694).  Crystallization with T. thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind; this protein's extended tail follows the mRNA channel and probably prevents RMF binding, which would prevent ribosome dimerization (PubMed:22605777).  This protein also stabilizes the 30S head relative to the rest of the ribosome, which may also prevent dimerization (PubMed:22605777).  Counteracts miscoding (translation errors) particularly efficiently at magnesium concentrations close to those observed in vivo but less efficiently at higher concentrations (PubMed:15219834).  Counteraction of miscoding was shown to be stronger than inhibition of translation, suggesting that the former activity could be the main function of this protein in vivo (PubMed:15219834).
What are the official names of this protein?
Ribosome-associated inhibitor A, Protein Y, pY, Ribosome associated factor Y, Spot Y.
What is the protein family that this protein belongs to?
Belongs to the HPF/YfiA ribosome-associated protein family. YfiA subfamily.
Protein: IF2_ECOUT
Sequence: MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARAAVRGGKGGKRKGSSLQQGFQKPAQAVNRDVVIGETITVGELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAGVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_PROM3
Sequence: MRVLGLMSGTSADGVDAVLAEFSGSPSEPKWSLLNLVCTPYPEDLRQTVINAGQGITLNSREWLELSESITEVHAQAALACDPSAQAELVGSHGQTVWHRPPQKNHRGASWQILQAPLLAELLKRPVVHDFRAADLALGGQGAPLVPMADAALLGRVGGWRGVLNLGGIANLTLIPPRSGPDRRASVMGWDCGPANSLIDLAVEQISKGKLAFDHDGSIAASGHPHTTTIERWLKEAFFQLPPPKSTGREQFGLADLEQRLKELPKLSTANRVATLTAFSAAVVAQDLNNLRIRNLVRPLELIVAGGGSRNPVLMNELRQRCRGMRVLNSDELGLSAEAREGLAFALLAWWHCLQHPGNAPAITGAKRAAVLGVRADPA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RDGC_SHIB3
Sequence: MLWFKNLMVYRLSREISLRAEEMEKQLASMAFTPCGSQDMAKMGWVPPMGSHSDALTHVANGQIVICARKEEKILPSPVIKQALEAKIAKLEAEQARKLKKTEKDSLKDEVLHSLLPRAFSRFSQTMMWIDTVNGLIMVDCASAKKAEDTLALLRKSLGSLPVVPLSMENPIELTLTEWVRSGSAAQGFQLLDEAELKSLLEDGGVIRAKKQDLTSEEITNHIEAGKVVTKLALDWQQRIQFVMCDDGSLKRLKFCDELRDQNEDIDREDFAQRFDADFILMTGELAALIQNLIEGLGGEAQR
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: AZOR_MARMS
Sequence: MATLLRIDSSASGENSKSRQLANEFVEKWLAKNPEGKVVARDVTANPLPHFTGETLGALFTPEENRTAEQQAIVAIGDELIAELEAADLVIVSAPMYNFGIPSTLKSYFDHVARAGRTFKYTETGPVGLVNKDAYIFAASGSFLAGAPVDHQVPHIQTFLGFIGLNVKDTFIAGGQAMGEPGEDAFNQAKSQIAVAV
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: ANGI_RHIAV
Sequence: MVMGLGLFLLVFMLGLGLTPPTLAQDNSRYRDFLTKHYDATPQGRNDRYCESMMRRRGLTSPCKDINTFIHGNSRHIKAICGDENGNPYGENLRISKSPFQVTTCNLRGGSSRPPCRYRATAGFRNIVVACENDLPVHLDQSIFRP
What is the function of this protein?
Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs).  Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus.  Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.  Angiogenin induces vascularization of normal and malignant tissues.  Angiogenic activity is regulated by interaction with RNH1 in vivo.
What are the official names of this protein?
Angiogenin, Ribonuclease 5, RNase 5.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).
Protein: NCB5R_ASPTN
Sequence: MSTFLQDNGDLSAVLVKFAPFAVAVIAILAAWKFTGSSKPRKVLNPSEFQNFVLKEKTDISHNVAIYRFALPRPTDILGLPIGQHISLAATIEGQPKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKYLTTLKIGDTLKVRGPKGAMVYTPNMCRHIGMIAGGTGITPMLQIIKAIIRNRPRNGGNDTTKIDLIFANVNEEDILLRDELEKLAKEDDGFRIFYVLNNPPPGWNGGFGFVTAEMIKEHLPAPAKDVKILLCGPPPMVSAMKKATESLGYTKARPVSKLEDQVFCF
What is the function of this protein?
NADH-dependent reductase for dph3 and cytochrome b5.  Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase, predominantly cbr1.  By reducing dph3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex.  The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
What are the official names of this protein?
NADH-cytochrome b5 reductase 1, Microsomal cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: TRUB_PROM9
Sequence: MENKDGFLVINKDKGCTSHDCVKQIRKLLNTRKVGHTGTLDPEVIGTLPIAIGSATRFIQYLPQGKTYIGQIKLGIRTNTDDIHGEIINQKCWPKISDEKLDQYLNKFRGLIKQIPPKVSSVHVNGERAYKKSFNNENFELAPREVKIDELILMKWDQINGIIELKINCSAGTYIRAIARDLGEILNSEGCLLQLKRISACGFHEKNSIKISDIKKGIDQKNASNFIIPTISALNHISTLILNKEEDINFWQTGRAIKFDINYFNEGNNFDNKKPIKVVDKRKMLLGIGFLNKELTNINPKLVLNAK
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: NU5M_DICDI
Sequence: MYIVNLILPLIGSIITGIFGHKLGNRISIKIAVGCMMLTAISSLYIGYEILLCNSVVHFKLGTWMQVGSLNVEYGLLYDSLTSIMIIVITCISSMVHLYSMDYMKEDPHKTRFFSYLSLFTFFMMLLVTADNFVQLFFGWEGVGIMSYLLINFWYTRLQANKSALKAVILNRFGDFGLFFGILLVFLVFKSVDFSVIFTIAPFITEYTINLLGYEVNAITLIGSFIVIGVVGKSAQLGLHMWLPDAMEGPTPVSALLHAATMVTAGVFLVLRTSPLLSYSITILNILTIIGALTTLFATTIGIVQNDIKRVIAYSTCSQLGYMIFACGLLNYNASIYHLTTHAFFKALLFLSAGSVIHGLNDEQDMRKMGGLVNLMPLTYQCMLIGTLALTGFPFLSGYYSKDIILETSYATYYWEGTFAAIIGYVAAFGTTFYSFRLLILTFFNKPRMQYKTIAGVHEASTNMVIPLVILALCSIFIGYVTKDFFVGLGTPVWNNSFFAYPYNNLILESEVLQRELKLLPLFAFIYGVITPVLFYFNIKEDRMINVKQNLMVKESYFFFVKKWYFDFLSRVLIVVPFFHLSYDVMNKNLDKGLWEKIGVTGVATTLVTAFTALKLKNEITLSTYISYIVQTIILIIVVGIFSFMTGFIYMELCIIIGILYICLPSIKID
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ERA_STAEQ
Sequence: MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFIDTPGIHKPKHKLGDYMMRVAKNTLSEIDAIMFMVNVNEDIGRGDEYIMEMLKNVKTPIFLVLNKIDLVHPDTLMPKIEQYQSYMDFTDIIPISALEGLNVDHFIDVLKSFLPEGPKYYPDNQISDHPEQFVVSEIIREKILHLTSEEIPHAIGVNVDRMIKEDEDRVRIETTIYVERDSQKGIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: MSHR_FELCA
Sequence: MSVQGPQRRLLGSLNSTSPAAPRLGLAANQTGPRCLELSVPDGLFLGLGLVSVVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSSVLETAVMLLLEAGALAGRAAVVQRLDDIIDVLVCGAMVSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYDHTAVLLCLVSFFVAMLVLMAVLYVHMLARACQHARGIARLHKRQRPVHQGLGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPRHPICGCVFKNFNLFLTLIICNSIVDPFIYAFRSQELRKTLQEVLLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYN_AYWBP
Sequence: MKISIKDIFQKPELFYQKKILLNGWVRNCRYQKKLIFIDLNDGTFLENLQIVCKEIKNIETADINEFQENQKFNNNNKSSNNINLEKLKEILQIGASLQVEGILKATNNLKTPFEISAQNISLLGTSDFSYPLQPKKHSKVFLRQISHLRVRTKLFGAVFRIRNTAFFALHSFFQKKGFFHINTPIITPNDGEGVGELFQITTLNLEVLPQTKNIPNAFKPVNENTSKKGIDYKKDFFGKKVFLTVTGQLEAEAMALGLNKVYTFGPTFRSEKSNTTRHAAEFWMLEPEMAFCDLSQNLKVAQEMLQFVISKCLEQNYQDIEFLDKTEKNGLIEELQNIAEEKEFLTVKYEQALEILQKSNTKFENPLFYGVDLATEHEKYLTEKHFKKPVFIVDWPKEIKAFYMKNNPDQKTVAAMDLLFPRVGELIGGSQREENLSVLIEKMNQMKISQKDLEWYLDLRRFGGCIHSGFGLGFERLLIFLTGLDNIRDVIAFPRTYHNLVF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_NITEC
Sequence: MKLHILAVGNKMPDWIKKGYTEYSQRMPKEAEMQLVEIKPEKRIGKKTEQLLQAESERIRIALPPGCHIVVLDESGKQATTVRLAELMTNWRESGRDVTFIIGGADGLHRDIKQIAHEKLALSTMTLPHGLARVLLAEQLYRAFSITRNHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.