PharMolix/UniProtQA huggingface dataset:
Protein: PELO_HALLT
Sequence: MRISDRGYGEEGRERLTLVPENVDDLWHLAHVLEPGDLVEGDTTRRIQRNDDQMRDTGGQREHLFVTLQVDEVEFARFANRLRVSGVIVGCSREDQLNAHHTINVEEHDEITVEKHFKPDQTERLEEATEAAENPDVAIATVEEGAAYVHTVQQYGTEEYASFTKPTGKGDYSRPREELFAELGEALAHLDADAVILAGPGFTKQDALDYITEEYRDLADRITTVDTSAAGDRGVHEVLKRGAVDEVQKETRISKEATLIDDLTAEIAQGAKATYGPEDVAEAAEFGAIETLLVVDDRLRTERQGEGDWSIDVNEVIESVEQQGGDVVVFSSEFAPGEQLSNLGGIAAILRYRLQ
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTPD_ECOLI
Sequence: MNKHASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYNDTHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMAIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGYAQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITILFWKEWSVYALIVATIIGLGVLAKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFAVMLCGVFLAWVVKESVAGNRTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMSQITRIEIPGVTGVLTGIYMLLSGAIANYLAGVIADQTSQASFDASGAINYSINAYIEVFDQITWGALACVGLVLMIWLYQALKFRNRALALES
What is the function of this protein?
Probable proton-dependent permease that transports dipeptides.
What are the official names of this protein?
Dipeptide permease D.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CATA_STAA8
Sequence: MSQQDKKLTGVFGHPVSDRENSMTAGPRGPLLMQDIYFLEQMSQFDREVIPERRMHAKGSGAFGTFTVTKDITKYTNAKIFSEIGKQTEMFARFSTVAGERGAADAERDIRGFALKFYTEEGNWDLVGNNTPVFFFRDPKLFVSLNRAVKRDPRTNMRDAQNNWDFWTGLPEALHQVTILMSDRGIPKDLRHMHGFGSHTYSMYNDSGERVWVKFHFRTQQGIENLTDEEAAEIIATDRDSSQRDLFEAIEKGDYPKWTMYIQVMTEEQAKNHKDNPFDLTKVWYHDEYPLIEVGEFELNRNPDNYFMDVEQAAFAPTNIIPGLDFSPDKMLQGRLFSYGDAQRYRLGVNHWQIPVNQPKGVGIENICPFSRDGQMRVVDNNQGGGTHYYPNNHGKFDSQPEYKKPPFPTDGYGYEYNQRQDDDNYFEQPGKLFRLQSEDAKERIFTNTANAMEGVTDDVKRRHIRHCYKADPEYGKGVAKALGIDINSIDLETENDETYENFEK
What is the function of this protein?
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.  Involved in resistance to paraquat when fur is absent and to tert-butyl hydroperoxide.  Is important for survival under glucose starvation and desiccation conditions.  Not required for virulence although is necessary for nasal colonization.
What are the official names of this protein?
Catalase.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
Protein: UFM1_MOUSE
Sequence: MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC
What is the function of this protein?
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:21494687).  The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1.  Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.  Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription (By similarity).
What are the official names of this protein?
Ubiquitin-fold modifier 1.
What is the protein family that this protein belongs to?
Belongs to the UFM1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: DNAJ_GEOTN
Sequence: MAKRDYYEVLGVSKNATKDEIKKAYRKLSKQYHPDINKAPDAAEKFKEIKEAYEVLSDDEKRARYDRFGHADPNEAFGGGFQGGGFDFGGFSGFGGFEDIFETFFGGGSRRRASGPRKGADLEYMMTLTFEEAAFGKETEIEVPHEETCDTCHGSGAKPGTSPQSCPHCHGSGQVTSEQATPFGRIVNRRTCPVCGGTGRHIPEKCPTCGGTGHVKKRKKIHVKIPAGVDDGQQLRVAGKGEPGVNGGPPGDLYIIFRVQPHEFFKRDGDDIYCEVPLSFAQAALGDEIEVPTLHGDVKLKIPAGTQTGTRFRLKGKGVPNVRGYGQGDQHVIVRVVTPTKLTEKQKQLLREFDRLGGETMHDGSHGRFFEKVKKAFKGET
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RARR2_HUMAN
Sequence: MRRLLIPLALWLGAVGVGVAELTEAQRRGLQVALEEFHKHPPVQWAFQETSVESAVDTPFPAGIFVRLEFKLQQTSCRKRDWKKPECKVRPNGRKRKCLACIKLGSEDKVLGRLVHCPIETQVLREAEEHQETQCLRVQRAGEDPHSFYFPGQFAFSKALPRS
What is the function of this protein?
Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1).  Acts also as a ligand for CMKLR2.  Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2 (PubMed:27716822).  Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue.  Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues.  Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases.  Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells.  Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells.  The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production.  Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease.  Exhibits an antimicrobial function in the skin.
What are the official names of this protein?
Retinoic acid receptor responder protein 2, Chemerin, RAR-responsive protein TIG2, Tazarotene-induced gene 2 protein.
Protein: RL21_WOLWR
Sequence: MFAVIETGGKQYLVKEGSIIKVEKLEAEEKKEVEINKVICISNNGLSYSSNATVKAEVLEQCRGEKIIIFKKKRRKNYRRKTGHRQYITVLRINEISLQK
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: GPMB_SALPC
Sequence: MLQVYLVRHGETQWNAERRIQGQSDSPLTAKGEQQAMQVGERARSLGSTHIISSDLGRTKRTAEIIAQACGCDITFDSRLRELDMGVLEKRQIDSLTEEEEGWRRQLVNGTQDGRIPGGESMQELSDRVHAALASCLELPQGSRPLLVSHGIALGCLVSTILGLPAWAERRLRLRNCSISRIDYQESQWLASGWVVETAGDVSHLDAPALDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.
Protein: KCY_CHLFF
Sequence: MIITIDGPSGTGKSTVAKALAQRLKFNYCNTGAMYRTLAYTHLQEPWNCLSIQELIDNPPFSFSFISEQPLEAFLDGHRLSEELGTQEVANAASRLSQLPEVRSFMHKLQRKYAELGNCVFEGRDMGSKVFPDADVKIFLTASAEVRALRRLKDLPKGSLSQEALHAELVKRDEADSRRIHDPLVIPEGAIVLDSSDLTISQVLEKILALVSPEMP
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_BURL3
Sequence: MKQVRLLPSATVRAACAVAVAAFAAGCAQIPRDPIIQQPMTAQPPTPMSMQAPGSIYNPGYAGRPLFEDQRPRNVGDILTIMIAENINATKSSGANTNRQGNTDFNVPTAGFLGGLFAKANLSATGNNKFAATGGASAANTFNGTITVTVTNVLPNGNLVVSGEKQMLINQGNEFVRFSGVVNPNTISGANSVYSTQVADAKIEYSAKGYINEAETMGWLQRFFLNIAPW
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: CM3K_CONRE
Sequence: MMFKLGVLLTICLLLFPLTALQLDWDQPGDHMLDISSEIDDRWFDPVRKCCMRPICMCPCCIGP
What are the official names of this protein?
Conotoxin reg3k, Reg3.1, Rg3.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CP239_MOUSE
Sequence: MDLVTFLVLTLSSLILLSLWRQSCGRGSLPPGPTPFPIIGNFLQIDIKNVSQSLTNFSKAYGPVFTLYLGSRPTVVLHGYEAVKEALIDHGEEFSDRGSIPMVEKINNGLGIVFSNGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQDRFDYKDKDFLMLMEKLNENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNVKYIRSYLLEKIKEHQESLDVTNPRDFIDYYLIKQKQANHIQQAEFSLENLACTINNLFAAGTETTSTTLRYALLLLMKYPDVTAKVQEEIDHVIGRHRSPCMQDRNHMPYTDAMIHEVQRFINLVPNNIPRAVTCDIKFRNYLIPKGTTVVTSLTSVLHDSKEFPNPELFDPGHFLDANGNFKKSDHFMPFSAGKRVCAGEGLARMELFLFLTTILQNFKLKSLVHPKDIDMIPFVNGLIALPPHYQVCIIPR
What is the function of this protein?
A cytochrome P450 monooxygenase that primarily catalyzes the epoxidation of 11,12 and 14,15 double bonds of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) forming 11,12- and 14,15-epoxyeicosatrienoic acids (11,12- and 14,15-EET) regioisomers.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase).
What are the official names of this protein?
Cytochrome P450 2C39, CYPIIC39.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: SYT_XANAC
Sequence: MINITLPDGSRREFESPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDVIDHDASLRIITAKDAEGVEIIRHSCAHLVGHAVKQLYPEVKMVIGPVIAEGFYYDIYSERPFTPEDMAAIEQRMQELIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRLIEDMSEDITAMGLYYHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEEADKRDHRRIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILDVSLWQKSGHWDNYQDAMFFTESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGILRVRGFTQDDGHVFCLEPQIESEVTAFHQQALAVYTAFGFDDIQIKIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTWQLGTMQVDFMMPGRLGAEYVDENSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPSWLAPVQVVVANITDAQAEYVDSVRKTLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDREKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HM30_CAEBR
Sequence: MSLLDPRQFLLPAFYLDPSTQAFLTQAVSNHKLGTASSFRISDILEPSPNNSTYSHDLDPSPQSVRSDLSTSPRASSPDRNSPMSKKSRKARTIFTDKQLQELENTFEKQKYLSVQDRMDLAHRMGLSDTQVKTWYQNRRTKWKRQATSGMDLLSEPGNLSAVQNLIRSSPYWANYITALPMGGQMGQMPMMGLPMPMIVPPAQHFQATSSSNSPSTHKSSESPQLDVSSNSD
What is the function of this protein?
Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination.  In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway (By similarity).
What are the official names of this protein?
Homeobox protein ceh-30.
What are the subcellular locations of this protein?
Nucleus.
Protein: LON_DICT6
Sequence: MEERELNQTQDIPEVLPILPLRETVVYPQMLIPLIVGREKSIRLVEDALSGNKLIGMCMQKTPVEDPTPDDIYRIGTVGIIVRSLRFPDNTLRLFVQGLQRIRVIEFLETEPYFKAKVEVIEEKVEKTVEIEGMMRNLLNLFQKMASLIPQFPEELLINAMNIQEPGRLADFIAFNTNLNINEKQEILETIDVKERLQKVTYYLTRELEILEIANKIQNEVKNEIEKSQKEYFLRQQMKAIQKELGEIDPREMEINELRQKLQEAKLPPEAMKEAERELERLSLMPPGSAEYTVTRTYLDWLISLPWAISTEDNLDIKRAEEILNEDHYDLEKVKERILEYLAVRKLKSDMKGPILCFVGPPGVGKTSLGKSIARALGRKFVRISLGGIRDEAEIRGHRRTYVGALPGRIIQGIRKAESNNPVFMLDEIDKLGSDFRGDPAAALLEVLDPEQNNAFVDNYLGVPFDLSKVMFIATANVLYTIPPALLDRMEVIELPGYTEYQKMGIAKGFLIPRQLKEHGLEKEQIEFSDDAIRKIIREYTREAGVRNLEREIASIIRKVAKGIAEGSITEKVIVKVEDVPKYLGPEKYTYGMKGEKDEVGVATGLAWTEAGGDILFVEALVVEGKGNLILTGKLGEVMQESAKTALSYVRSKLKDLNVSYELLEKADIHVHVPSGAIPKDGPSAGVTIATAIASALTRRPVKKDIGMTGEITLRGKVLPVGGIREKVLAAHRAGLTAVIMPKENKKDLEEIPEEVKKEITFYFVEHADEVLNLALLEVKESAEQRNPERIG
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSM3_YEAST
Sequence: METPLDLLKLNLDERVYIKLRGARTLVGTLQAFDSHCNIVLSDAVETIYQLNNEELSESERRCEMVFIRGDTVTLISTPSEDDDGAVEI
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.  Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6. U5 snRNP, and free U6 snRNP).  It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  It probably also is involved in degradation of nuclear pre-mRNA by targeting them for decapping.  LSM3 binds specifically to the 3'-terminal U-tract of U6 snRNA.  LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.  LSM3, probably in a complex that contains LSM2-LSM7 but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA.  LSM3 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm3, SmX4 protein.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TM129_DANRE
Sequence: MDRPDATFTLAYVVFALCFVFTPNEFRSAGFTVQHMFSEWLGSEDISFIQHHIRRTTLTVLFHSFLPLGYYIGMCFAAPEQNLMYVHHASQGWQMYFGLSLVIQLLSCALAFYWSRRGWANHPICKALSVHALPQSSWRAVASSINTEFRRIDKFASGSPSARVIVTDTWVMKVTTYSLHVALHQDCHLTVTDSKHHSLSPDLNTPVQIVTITVGSINPRVKSFDIRLKSTEYAELQEKLHAPIRNAANVVIHLTMSELFLETFKSYVRMNVVYKCPSGQELEPCIGCMQVNANVKLLCLCQSDEGECQQCYCRPMWCLTCMGKWFASRQDQQQPETWLSSRVPCPTCRAKFCILDVCPIE
What is the function of this protein?
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2.
What are the official names of this protein?
E3 ubiquitin-protein ligase TM129, RING-type E3 ubiquitin transferase TM129.
What is the protein family that this protein belongs to?
Belongs to the TMEM129 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GUC2C_MOUSE
Sequence: MTSLLGLAVRLLLFQPALMVFWASQVRQNCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCALMGPSCTYSTFQMYLDTELNYPMISAGSYGLSCDYKETLTRILPPARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVAEDTVVILVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPVAENPNFIWKNHKLPNDVPGLGPQILMIAVFTLTGILVVLLLIALLVLRKYRRDHALRQKKWSHIPSENIFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPSPPTVENQQRLQTEFSDMIVSALQKRQASGKKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF
What is the function of this protein?
Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP.
What are the official names of this protein?
Guanylyl cyclase C, GC-C, Heat-stable enterotoxin receptor, STA receptor, Intestinal guanylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
Protein: AROE_BACAC
Sequence: MKRLYGVIGNPIGHSLSPVMHNDAFEHLKMDAHYHAFLVKEEVLGEAVRGLKALGISGFNVTTPHKVAIMDYLDEIDPLAKQIGAVNTVVHKDGKLIGYNTDGIGFVRALQSISSEPLQEKRILLLGAGGASRAIYFSLADAGVKEIDVANRTVDKAKELIAACTATVHSVALSLEKATKEQGNYDIIIQTTTIGMHPRVEHTPLQISSLKKGTIVSDIIYNPFETKILCEAKEQGAIIQNGIDMFVYQGALAFEMWTGCVPNIERMKQLVIRKLGG
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: GH_FHV1
Sequence: MMCLIIYLSIFLIIVSRMLTGLPMMDRPDEGGLARRTVGEVEGEFSYRDDVDVADVRNLFIMLPKNGSDIFLFIFDRRSQRQRGTMFLFPKAGFVQPTPAKVRDEAAAAPFGFISPVYPLSSLLFNPYNGRYLTTRHLIAFEVTPESSLHDWYFARSPTTATQTQPLGHITNPPRRSPKDKPTTSGHTDLIIRYCALELDFFQDTRRQRDGIYLPNYEAVWPLAMNFLEGMWIWSNRTLVNVTIGVGFMGFSLTSISYPPLEIIVTPHYTNARMITRFKSSLVLDPPGPSEGPLYKVYVLGYGNNRINGSFYKTMRTIASYPRTKPRLSLPPFHGTYGTALFLSHATPQDMDGTTAYISKISTRLATALFSLSEVRRLSGYVAIDELIDLDFNTRLLANTLLADGMQNFQDPINITYYYNSDVGRTHLRDALDTIDHQHVSHGSLITRARYLQLIYTYTSMEKQSQLSLKLSGDIVKDLYLETLYSDVVRWNTTAKQALFLSSMLIYIAGNIQSSVEQEAINAGRMLFLQCTSMCTTEHASTVRWNPQQILYDLTKSSTRFNIFDGFSPCMASNRYDIISPYGILDLFSAFPISSYRSIEKPAVDSNTHNIIFNLRNLYTFIPELFSCPGVSSNHQRPIAVLPIGINCTYLITRRDPRRGTLYIVDGIDVSNPIIISYLRSGECGIERGIILPGNLNNPENTDQCLYCGCVFMRYKSSGEIVDLLLINDKAVELELVAGENSTISAFNPTKYSSPSSVLLLFPNGTIVTLMAFTSHEVIVFSSNFIWASIGGVFAACLIIYIIIKMLCSFTPDVRYTLLNN
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL.  May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein H, gH.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein H family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: YQGF_MESM1
Sequence: MRKLGIDLGKIRTGFAISDDSNKISLPLKTFIQKNANFNNIILEIKKILLEYQIDTIVIGLPIKINNEKTKSTIFVENFKKHLEKEINLPIFFVNEYNSSVLANLSINEMKSKKRKTIVDKISAQIILNDFLNNYFIKEKYDEN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
Protein: TGT_BACCZ
Sequence: MTAIRYEFIKTCKQTGARLGRVHTPHGSFDTPTFMPVGTLATVKTMSPEELKAMDSGIILSNTYHLWLRPGHEIIREAGGLHKFMNWDRAILTDSGGFQVFSLSDFRRIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPFPATFEYMKKSVERTSRWAERCLKAHERPQDQGLFGIVQGGEFEELRRQSAKDLVSMDFPGYAVGGLSVGEPKDIMNRVLEFTTPLLPDNKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTSEGRLVVKNAKFARDFGPLDPNCDCYTCKNYSRAYIRHLMKCDETFGIRLTSYHNLHFLLNLMEQVRQAIREDRLGDFREEFFEQYGFNKPNAKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: ARGR_ENTFA
Sequence: MKKAERQRLIKQLIMQQEIETQDELITRLEEIGVRATQATVSRDIREMSIVKTHGADGRVKYAIFSQAQGTSSEEKLRESVKDSVVRMERVQFIVILHTEMGNADVVSNFLDEVAYPEVAGTVAGADTIIVITRSEEDAEHFIERIENMIF
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.