PharMolix/UniProtQA huggingface dataset:
Protein: PNO1_ASPOR
Sequence: MPAPTALKGLDQTTTAGVPVTQAAIVQDDEVLIDAQTSAEESVPVLAPLGENAQDTDMRIDEEGRPVFTPAKDTNTVYRVETRKVPVPPHRFSPLKASWSRIYPPLVEHLKLQVRMNIKSRAVELRTSKFTTDTGALQKGEDFVKAFTLGFDVDDAIALLRLDDLYIRSFEIRDVKASLHGEHLSRAIGRIAGKDGKLKHSIENATRTRIVLADQKIHLLGGYRNILVAQEAVVSLILGSPPGKVYGNLRKVASRMKERF
What is the function of this protein?
Required for small ribosomal subunit (SSU) synthesis.  Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein pno1.
What is the protein family that this protein belongs to?
Belongs to the PNO1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: RL18_THEPX
Sequence: MITKPNRNELRKRRHLRVRKKVFGTPERPRLNVFRSLKHIYAQIIDDTKGHTLVHASTLDPELRGIAKGANKQSAKLVGELIAKRALEKGIKDVVFDRGGYIYHGVVKELADAARQAGLNF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: HIS8_RIPO1
Sequence: MLPIRECVSQTPGYVPGEQPQTTDYIKLNTNENPYPPPDKIFEGLQQELTKVRLYPDPVSTQLRKAAANVFGISYQNILAGNGSDDILNIAVRTFVNPGEVVAFLDLTYSLYETIARVHGASIVQIPTNNQFELNGPIICPEAKLIFVASPNPPVGKHLNRDYLEETCKQATGVVLIDEAYVDFSDENHLDFLEKYDNVIISRTMSKSYSLAGMRVGFGVSSTEIIEQMDKVRDSYNLDRIAQTLGTAVLNYQDYFKGVWQQVRHTRTRLIESLRTLEFLVFDSDSNFVLASPQWIAASDLYTQLKERKVLVRYFSHPRIKDYVRISIGTDQEIDRLLEAIHEIKGSN
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: ANMK_XANOR
Sequence: MPVLEHVDSLLYLGLMSGTSADGIDAALVRFAEDTHRRCELVAGTTVAWEPQLRETLVALGQGAETVAIDALGQLDAQVGLAFAAAANQLIRDSGVERRRIRAIGSHGQTIRHRPEADPAFTWQIGDASRIAEHTGITTVADFRRRDVAAGGQGAPLMPAFHLAMLGAGDQDSAVLNLGGIGNLTLIPRDGAVLGFDTGPANALLDSWCQRHHGTPFDAEGAFAASGRVDAALLQALLADPWFALPPPKSTGREQFHLDWVLQAMGSARLDAADVQATLLELTAASVADALLRLQPSTRRVLVCGGGVRNPVLLARLAARLPGVVVESSARYGLDPDYLEAMGFAWLAAELLAGRAANLPSVTGAAGPRLLGAIYPA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: SNPF_DROPS
Sequence: MFRFNPQLSHGCALALICCLLNLLMMHQPTNAELSPVVQGEFFLPILPDDHPPNTDTSFGGPISNLYDNLLQREYAGPVVFPNHQVERKAQRSPSLRLRFGRSDPDMLNNIVEKRWFGDVNQKPIRSPSLRLRFGRRDPTLPQMRRTAYDDLLERELTLNNQQQQQLGDTADDLSADYDGLYERVVRKPQRLRWGRSVPQFEATIGDNDQLYNSLWNSEKMRRMLLALQQYEAAPGHVAGYANDGDDTEAQLDEDTSEFQREARKPMRLRWGRSTGKAPQIETSSIAPKN
What is the function of this protein?
Plays a role in controlling food intake and regulating body size.
What are the official names of this protein?
Short neuropeptide F.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: RK20_EPIVI
Sequence: MTRIKRGYIARRRIKKFRLFASSFLNAHSRLTRTITQQKIRALVSSDRDRNNKKRKFRSLWITRINAVIREEGVSYSYKNFIYAQYKIQLLINRKILAQIAILNRNFFYMIFNEIRKEADLKEYIRIN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20, plastid.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid.
Protein: PSBK_OSTTA
Sequence: MTQIFLIGRLPEAYAPFDPIVDVLPIIPVLFLLLAFVWQASVSFR
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein K, PSII-K.
What is the protein family that this protein belongs to?
Belongs to the PsbK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ATPA_SACD2
Sequence: MQQLNPSEISEIIKQRIDNLAVSTEAQNEGTVVSVTDGIIRIHGLADVMYGEMIEFEGGVYGIALNLERDSVGAVVLGDYQGVAEGQSCKCTGRILEVPVGEELCGRVVDALGNPIDGKGPINAKKTDAIEKIAPGVIARQSVDQPVQIGLKAVDTMVPIGRGQRELIIGDRQTGKTAVAVDAIINQKGTGIKCIYVAIGQKASSVASVVRKLEEHGAMDHTIVVAATASDPASMQFLAPFAGCTMGEYFRDRGEDALIIYDDLTKQAWAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNADYVEQLTNGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETDLFNAGIRPAMNAGISVSRVGGSAQTKVIKKLSGGIRTALAQYRELAAFSQFASDLDEATKAQLEHGERVTELMKQKQYSPQSVGEMAVVVYAANEGYLKDVEVSKIGDFESALLSYMNSSHADLMNTMNGGSYSDEIAGQLKSALDTFKATQTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NIP7_YEAST
Sequence: MRQLTEEETKVVFEKLAGYIGRNISFLVDNKELPHVFRLQKDRVYYVPDHVAKLATSVARPNLMSLGICLGKFTKTGKFRLHITSLTVLAKHAKYKIWIKPNGEMPFLYGNHVLKAHVGKMSDDIPEHAGVIVFAMNDVPLGFGVSAKSTSESRNMQPTGIVAFRQADIGEYLRDEDTLFT
What is the function of this protein?
Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
What are the official names of this protein?
60S ribosome subunit biogenesis protein NIP7, Nuclear import protein 7.
What is the protein family that this protein belongs to?
Belongs to the NIP7 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: ADHX_SCYCA
Sequence: AGTVGKVIKCKAAVAWEAGKPLCIEEIEVAPPKAHEVRIKIIATAVCHSDSYTLSGSDSEGLFPVILGHEGAGIVESVGEGVTCVKAGDRVIPLYIPQCGDCNFCLNPKTNLCQKIRVTQGQGLMPDKTSRFTCKGQLLYHYMGTSTFSEYTVVADISVAKIDEAAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAGIMGCKAAGATRIIGVDLNKDKFTKAKEFGATEYINPKDYDKPIQEVLVGLTDGGVDYSFECIGNVKTMRAALEACHKGWGTSVIVGVAPAGHEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVKEYMAKKLKVDEFVTHTLPFNQINESFELMHAGKSIRCVLSF
What is the function of this protein?
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
What are the official names of this protein?
Alcohol dehydrogenase class-3, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_HELPJ
Sequence: MTKTAKVNDIVRDWVVLDAKDKVFGRLITEIAVLLRGKHRPFYTPNVDCGDFVVVINANKVKFSGMKLEDKEYFTHSGYFGSTKSKTLQEMLEKTPEKLYHLAVRGMLPKTKLGKAMIKKLKVYRDDKHPHTAQTSKKDAK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: CA185_HUMAN
Sequence: MASPKGFFNYLTYFLAAGAVTLGIGFFALASALWFLICKRREIFQNSKFKAIDERCRQRPSMAKIKSHSQCVFISRNFHTGRFQLQEEQRKKEAAHIKAIKDHSKDEPQLATKNIICDPSETSSTTNRSSVTLSLSTLPSDSYYSQSIEAADDWFSDDSLVKRNSPMPSLGEPLMEKVFSYLSTISLEEGTESVLNDTL
What are the official names of this protein?
Uncharacterized protein C1orf185.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IGF2_RAT
Sequence: MGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ
What is the function of this protein?
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion.  Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
What are the official names of this protein?
Insulin-like growth factor II, IGF-II, Multiplication-stimulating activity, MSA, Multiplication-stimulating polypeptide.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEPC_BACSE
Sequence: MNKTFKYIVLLALACFVGKANAQELKTEVFSLLNLDYPGLEKVKALHQEGKDADAAKALLDYYRARTNVKTPDINLKKVTIGKDEQKMADEALQHTFFAHKGYQPSFNYGEDIDWRYWPVKDNELRWQLHRHKWFTPMGKAYRVSGDEKYAVEWTKQYIDWIKKNPLVKVDKKEYEMTGDNQLKGDVENARFAWRPLEVSNRLQDQTSQFQLFLPSPSFTPEFLTEFLVNYHKHAIHILGIYSAQGNHLLFEAQRMIYAGAFFPEFKEAAAWRKSGIDIMNREINVQVYNDGGQFELDPHYHLAAINIFCKALNIADLYGFRNEFPQEYLDTIEKMIVFYANVSFPDYTNPCFSDAKLTNKKEMLKNYRNWSKMFPKNQFIKYLATDGKEGALPEYLSKGFLKSGFFVFRNSWGTDATQMVVKAGPKAFWHCQPDNGTFELWFNGKNLFPDSGSYVYAGEGEVMEQRNWHRQTCVHNTVTLNNKNLDQTESVTKLWQPEGNVQILVTENPSYKNLKHRRSVFFVDNSYFVIVDEMVGSQKGSINLHYQMPKGEIANSREDMTFVTQFEEGSNMKLQCFGPEGMTMKKEPGWCSTAYRKRYKRMNVSFNVKKDSEDAVRYITVICPIKNSADAPKLSAKFKNKTFNENGLEVEVKVNGKKQSLNYKL
What is the function of this protein?
Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides.  Also able to degrade heparin and hyaluronic acid.  Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.  Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.
What are the official names of this protein?
Heparin-sulfate lyase, Heparin-sulfate eliminase, Heparinase III, HepIII, Heparitin-sulfate lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 12 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RADB_PYRAB
Sequence: MTLTTGVKGLDELLGGGVARGVILQVYGPFATGKTTFAMQVGLLNEGKVAYVDTEGGFSPERLKQMAESRGLDPEKALSKFIIFEPMDLNEQRRIISKLKTVVSDKFSLVVVDSLTAHYRAEGSRDHVELAKQLQVLQWLARKKNVAVIVVNQVYYDSNTNTLRPIAEHTLGYRTKDILRFEKFRVGVRLAVLERHRFRPEGGIVYFKITDKGIEDVLKAKPENGEENI
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  May regulate the cleavage reactions of the branch-structured DNA.  Has a very weak ATPase activity that is not stimulated by DNA.  Binds DNA but does not promote DNA strands exchange (By similarity).
What are the official names of this protein?
DNA repair and recombination protein RadB.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
Protein: PAND_TERTT
Sequence: MQITLLKGKLHMACVTQAELWYDGSCAIDADLVKLAGLREFEQIDIYNVDNGERFSTYVILAEPGSKTISMNGAAARKVQVGDRIIIAAYAGMEEAEADRHKPKLVYLNSDNSVNRTSNTIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_BDEBA
Sequence: MSSRGYEAVIGIEIHVQLSTKTKIFSSESTAFEAGDNENTSPVSVGMPGTLPVLNSKVVEYSIKTGLALGCDIRRKSVFARKNYFYPDLPKGYQISQYDQPICENGSITFKVDGKEKTVSITRAHMEEDAGKSNHHGEYTLINYNRSGIPLLEVVSGPDMRTPQEAAEYARTIRQIVRYLDVCDGNLEEGSLRCDCNVSVRKEGAKQFGTKVEIKNINSFRFVEKAIEYEIERQIDCVERGDKIIQETRLWDPDKNRTFSMRAKEDAQDYRYFPDPDLQPVIVTDSMIEKYKKELPELPIARAQRFQDDHALPELDATVLTTEKDLADFYEDTAKESKNFKASSNWIMTELLRELNSANKNIKDSPIKPAQLGKMIAMIDKGTISGKIAKTIFQEMWASGNDPEVIMKEKGLVQISDPAAIEKLVDEVLAANAQTVEDHKSGKKKNLFGFFVGAVMKASKGQANPDLVNKILLEKLK
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: INLR1_HUMAN
Sequence: MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR
What is the function of this protein?
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity.  The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.  Determines the cell type specificity of the lambda interferon action.  Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.  Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense.  Plays a significant role in the antiviral immune defense in the intestinal epithelium.
What are the official names of this protein?
Interferon lambda receptor 1, IFN-lambda receptor 1, IFN-lambda-R1, Cytokine receptor class-II member 12, Cytokine receptor family 2 member 12, CRF2-12, Interleukin-28 receptor subunit alpha, IL-28 receptor subunit alpha, IL-28R-alpha, IL-28RA, Likely interleukin or cytokine receptor 2, LICR2.
What is the protein family that this protein belongs to?
Belongs to the type II cytokine receptor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: FLIA_SALTY
Sequence: MNSLYTAEGVMDKHSLWQRYVPLVRHEALRLQVRLPASVELDDLLQAGGIGLLNAVDRYDALQGTAFTTYAVQRIRGAMLDELRSRDWVPRSVRRNAREVAQAMGQLEQELGRNATETEVAERLGIPVAEYRQMLLDTNNSQLFSYDEWREEHGDSIELVTEEHQQENPLHQLLEGDLRQRVMDAIESLPEREQLVLTLYYQEELNLKEIGAVLEVGESRVSQLHSQAIKRLRTKLGKL
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor controls the expression of flagella-related genes.  May regulate the expression of genes involved in virulence.
What are the official names of this protein?
RNA polymerase sigma factor FliA, RNA polymerase sigma factor for flagellar operon, Sigma F, Sigma-28.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. FliA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURP_SULAC
Sequence: MDTVLTIGSHSSLQILHGAKKEGFKTVQITPKNRVNFYSQFSFIDEILGYNNEDEAVEFVNKYSNRGALIPHGSLVEYVGSERVSKITTKIFGNRNLFAWESNQKKKMSLLRRSGIQVPEEFENVEDVDRLVIVKLPGAKGGKGYFIAKTKSEVKEGLNRLISSKLIKDVNDVIIQEYVIGVPMYFQFFYSPILNRLEITGIDIRYETNVDGLRRLPENLADPTFVVVGNIPAVARESLLPKVYDYGMSFVNTVKEVVPPGMIGPFCLESVVKDDGSIVVFEFSGRIVAGTNLYIAGSPYSWLYWDEPMSVGRRISREIRLALNSNKLEVIFT
What is the function of this protein?
Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
What are the official names of this protein?
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RUVC_CERS5
Sequence: MRVLGIDPGLRNMGWGVIDVSGTRLAHVANGICHSDSGDLAQRLLSLHRQLTDILARFAPDTAAVEHTFVNKDGVATLKLGQARGIALLVPAQAGLAVGEYAPNAVKKTVVGVGHAAKEQIQHMVRLHLPGVELAGADAADALAVAICHAHHVQSSGRLEAALARAAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: CNO6L_MOUSE
Sequence: MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNNLARIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNDNYLRVLPYELGRLFQLQTLGLTGNPLSQDIMSLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNWDADIISLQEVETEQYFTLFLPALKDRGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGTGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCSGKNGSSEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR
What is the function of this protein?
Poly(A) nuclease with 3'-5' RNase activity.  Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.  Additional complex functions may be a consequence of its influence on mRNA expression.  Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm.  Involved in deadenylation-dependent degradation of CDKN1B mRNA.  Its mRNA deadenylase activity can be inhibited by TOB1.  Mediates cell proliferation and cell survival and prevents cellular senescence (By similarity).
What are the official names of this protein?
CCR4-NOT transcription complex subunit 6-like.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Protein: FLIW_BACLD
Sequence: MIIKTKYHGETQIQEDQTIVFKNGLPGFTGEKKFVILPLSEDSPFVVLQSVQSEELAFIVASPFVFFKDYGFDLDETTVELLEIESAEDVEVMAILTIEEPFEKSTANLMAPIVVNRRKMLAKQVILHDSSYLTKQPIGGEAC
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_BARHE
Sequence: MHVSIFAVGRMKKGAEQALVHHYLDRFSKSCSAVGFHFKILQEISESRAPTACQRMEEEGRRLIEFLPEKCRLIVLDERGKTVSSFAFAEQLGFYRDEGVRDVIIALGGPDGHNEQIRNRADFLLSFGFMTWPHQIARILLTEQLYRAVTIASNHPYHRF
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSTU8_ARATH
Sequence: MNQEEHVKLLGLWGSPFSKRVEMVLKLKGIPYEYIEEDVYGNRSPMLLKYNPIHKKVPVLIHNGRSIAESLVIVEYIEDTWKTTHTILPQDPYERAMARFWAKYVDEKVMLAVKKACWGPESEREKEVKEAYEGLKCLEKELGDKLFFGGETIGFVDIAADFIGYWLGIFQEASGVTIMTAEEFPKLQRWSEDFVGNNFIKEVLPPKEKLVAVLKAMFGSVTSN
What is the function of this protein?
May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
What are the official names of this protein?
Glutathione S-transferase U8, AtGSTU8, GST class-tau member 8.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Tau family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SUFE_DICD3
Sequence: MAQLPDPQKLLRNFSRCSNWEEKYLYIIELGAGLAPLSDAQRQDGNRVSGCQSQVWIDLASNEQGNVVLHGDSDAAIVKGLIAIVFSLYQGLSVREIVELDVRPFFASLALTQHLTPSRSQGLEAMLRAVRARASALI
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity).
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAM_ECO7I
Sequence: MSDWNPSLYLHFAAERSRPAMELLARVPLENIEYVADLGCGPGNSTALLHQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPEQALDLIFANASLQWLPDHYELFPHLVSLLNSHGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQHFLTRYHQMLEEQYPLQENGEILLAFPRLFIVARRTE
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEPD4_HUMAN
Sequence: MVPGEEPARELMAVLLTPRFRRLVSQNELPGPGLNGPSSRNRRDGFCRKRRTGCSGPFQATQLWDGIIHSLQAQVEIKRRRHHLQTYKDCFTGSDAVDVVLSHLMQNTCLSSNDISCLKGVHLCQVLMNHKVFEPVGMKKLFKKEKELEFEDSNISLYRFLGNKSSYDCCKRQKDAENEFNETLRPGYEMISNPLAQEIGEERIEELIHTINGNPALCPNITVQKPFLRLSKEDVWKEQTLLCLLQLIHLPFLDNILEPPVKTQNLQLNKEEDLVITNTCLDRELIPSLCLPEK
What are the official names of this protein?
DEP domain-containing protein 4.