PharMolix/UniProtQA huggingface dataset:
Protein: WSS2_SCHPO
Sequence: MELKFSCRGNVIALSFNENDTVLDAKEKLGQEIDVSPSLIKLLYKGNLSDDSHLQDVVKNESKIMCLIRQDKDIVNQAISQLKVPDYSTNTYSLKPKKPHTTPKPASIYTFNELVVLDYPHKDRALRYLERLRDDTGIKKIMDSHRWTVPLLSEMDPAEHTRHDSKTLGLNHNQGAHIELRLRTDRYDGFRDYKTVKSTLIHELTHNVHGEHDSSFWELFRQLTKEADAADLLGKPGSYVSDRASYTPQQDNDDEDQKNHRRDLLLAAAERRKQSGSKVQKE
What is the function of this protein?
Metalloendopeptidase that acts selectively on DNA-binding proteins.  DNA is needed to bring the protease and substrates together to enable proteolysis.  Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde.
What are the official names of this protein?
DNA-dependent metalloprotease WSS1 homolog 2, DNA damage response protein WSS1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family. WSS1-like metalloprotease (WLM) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PTH_SOLM1
Sequence: MAVSAIIVGLGNPGPRYAATRHNFGFMVLDALMERARQLGGAPKATLTGRKDLEAVTLSLPVLPGGAFAQFACVKPLTFMNLSGRAVRAALDFYKLAPTDVFVLHDELDLPLGRMRLKRGGGNAGHNGLKSINQELGSPEFVRLRLGIGRPEGRDVAGYVLEAFRGDETPVVRQVVPAAVDGIMAFFEDGLETAQRRVGGFDAVPPPLPQP
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_SHEHH
Sequence: MESQRNILLIGLLFVSFLLWQQWQADQAPQPVAAAQTQSSIPASTVADSHSSDVPDADSAVPEAITASKELITVFTDQLEIKIDPVGGDIVYSALLSHKLEENGDDPFVLLEQTNDIYYIAQSGLIGRDGIDSSVKGRAHFDSASREYKLADGQDTLSVPLTYVSDKGVTYTKSFVFTRGKYNIAVDYKINNTSDASLQVQMYGQIKHSIKKSESSMMMPTYLGGAFSTDDIRYEKYSFDDMADKNLDDSTLGGWVAMLQHYFVSAWVPPATEKNIIFSSMKNGLANIGFRGELHDIAPGSEQVIKSEFYVGPKDQKALSVLSPSLNLVVDYGFLWWLAVPIYKLLMFFHSIVGNWGFAIILITLTVRGLLYPLTKAQYTSMAKMRNLQPKLAELKERFGDDRQKMGQAMMELYKKEKVNPMGGCLPILLQMPIFIALYWVLLESVELRHAPFMLWITDLSVQDPYYVLPILMGISMFVMQKMQPMAPTMDPMQVKMMQWMPVIFTVFFLWFPAGLVLYWLVGNLVAITQQKIIYAGLEKKGLK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: C80_SSV1
Sequence: MKARVEYIKLPRCYTKTYRKIEAKKNNDGTIELTLEETMQVISFKLPPALNAKLEQIAIKEKKSKSEIIRIALARYVENV
What is the function of this protein?
Essential for virus function.
What are the official names of this protein?
Uncharacterized protein C-80.
Protein: LTK_MOUSE
Sequence: MGCSHRLLLWLGAAGTILCSNSEFQTPFLTPSLLPVLVLNSQEQKVTPTPSKLEPASLPNPLGTRGPWVFNTCGASGRSGPTQTQCDGAYTGSSVMVTVGAAGPLKGVQLWRVPDTGQYLISAYGAAGGKGAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQQGQDACPGGSPESQLVCLGESGEHATTYGTERIPGWRRWAGGGGGGGGATSIFRLRAGEPEPLLVAAGGGGRSYRRRPDRGRTQAVPERLETRAAAPGSGGRGGAAGGGSGWTSRAHSPQAGRSPREGAEGGEGCAEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTSESDLLWADGEDGTSFVHPSGELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDCQWQAELWTAECTCPEGTELAVDNVTCMDLPTTASPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTRLPGPELELSKLRSSAIRTAPNPYYCQVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDVLNSPLPVEPGPILEEEEASRLGNRSLEGLRSPKPLELSSQNLKSWGGGLLGSWLPSGLKTLKPRCLQPQNIWNPTYGSWTPRGPQGEDTGIEHCNGSSSSSIPGIQ
What is the function of this protein?
Receptor with a tyrosine-protein kinase activity.  Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response.  Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (By similarity).  Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity).  The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival.  Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity).
What are the official names of this protein?
Leukocyte tyrosine kinase receptor.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform A]: Endoplasmic reticulum. Note=Retained in the endoplasmic reticulum. SUBCELLULAR LOCATION: [Isoform B]: Endoplasmic reticulum. Note=Retained in the endoplasmic reticulum.
Protein: EIF3B_EMENI
Sequence: MAPSFENLSEQDLHEEEEEEIDFSDLKAQYEVKLEEGLDTFVVIDGLPVVPEENRQKLIKFLLRKLNTVGHTSEDAVFMPLNEKNMSEGFAFVEYETAEQAVAAVKQLHGTPLDKKHTLLVNKLMDIERYGREGRIDEEYKPPNIEPFTEKEHLRSWLGDPNARDQFALYRGDKVGVFWNNKSNPPENVVDRAHWTQLFVQWSPKGTYLASVHPQGVQLWGGPTFSKQKQFPHPFVSLIEFSPGESYLTTWSARPIQVEEGHPVLTYEEDGKNIIVWDIVTGKPLRSFVSHDLAGPESEAQPKKKVQWPAFKWSADEKYVARMLQGQSISIYELPRMNLLGKTSVKIDGVMDFEWSPATVNRDGVKQYEQLLCFWTPEIGSNPARVALMSVPSKEIVRTRNLFNVSDVKLHWQSQGNFVCVKVDRHSKSKKSMATNLEIFRVREKGVPVEVVDSLKDTVINFSWEPNGARFVLITTGDASGAGAPPKTAVSFFAPEKKGVQAGNFKLVRTIEKKTSNAIYWSPKGRFVVVATVHSQSNFDLDFWDMDFEGEKNDNEKDLAANLQLMKTVDHYGVTDIEWDPTGRYVVSGASAWTHQMENGFNLHTFSGETLAENPTDKFKQFLWRPRPPTLLSKEEQKQVRKNLREYSKEFEEEDKYAVDIANTAVVEKRKRVLNEWVAWLKREKELLTEEKEAYGLPEEADQPKAAKDAPTNTEDKGETVVEEIVEEIVEESEEIIG
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit B, eIF3b, Eukaryotic translation initiation factor 3 90 kDa subunit homolog, eIF3 p90, Translation initiation factor eIF3 p90 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1368_BRUSU
Sequence: MKPLLSLDRVSVSRDGRNVLDKLSLSLAAGERLALIGDNGVGKTTLLRTIVGLEPASGEITAFGINCRNESDFRKIRAKAAYLFQNPDDQLFCPTVIDDVAFGPLNLGLSRQEAMELSNGLLHDLGLGHLAGRITHHLSGGEKRLVSLAAVLAMQPQVLLLDEPTNALDEKHLERMLAILSAQKIAMIIVSHDWEILERLTDRAVVLRNGKLLPAMLHRHSQWSEQVHLHYVEAEGSAL
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein BR1368/BS1330_I1363.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VU7_HHV6Z
Sequence: MSNFRLILETEGGKRVLCESIVLHFAFMFQTEIVPVCNDEFTLSSCVPTLDFDVDVLSAAYGDGLEISSPGLRCCIAWPPMYALTLGEFYHFHTHRWVSAYDWSSLLDTDEFLSAIGYAHPIYRDPNPDYDPYVMHSSTGKTIAVDTVTEKVYIIAESLVQFFNIGLRQFPPFAEAELDPEQEKMWFGETKCGREEFILLQRNLPAMKDYVAKHCGKRIRVDAFQDFDFSFCSLSDIYYLTGPGILEKITEKDYAIIGTCARSQAEPNCRAAIVMGSNCHIYIYVENRISKVSKSLRTFIRRGFDELLYKEKYSLDWNDDTLFYISDTETENLNRMLNGELPVLRSKPRHMCVRKDRLVKDRSKILFAVRLDEEDSLTVKFITKFLTPVFVGRLPATSRFVVPVSCARLTNGLQGTAAARFGIKGLHPSSDCVVWNRLIDYEYETYKYPSTYVRADQIADMVKNLKFMDNFDEKWQCITKLAFIGLYAGASLFNFASKPTLGYWCRYLCEYASMLLFQFESKLKELTKESTRQLGGYNLCHWGQELKDCLENKSDVFFRYDFFERIESCLIEHFMLLCGCVECRRMFIMYNKRGRKCDFGHCVRIQCFPMIGSIRLPAFLHLGEPYSVSLSSLIAKDLGLSMIEGQIEHSRLPISLQISVTPDKKALLTFLTNIVFIVFVVNTLYRVINAELDIYYDLFTEEVGKLCVTMEEEMKLGRNGCLGDLCYFSSMKQMKEIVRCPGEKSQFILKCWEALRIGFSVPAYKDYDETRFMEMFFLHHLHIKRFHEHNDRDLVSSDNLIPGFFIVNTHEENFLQRLQRVVLPVAEDYLTNTRCINGTMAFFFSGLKYFGSGNHRGVQISPEKDVRAIGYKLGSLDVLRDDYKYYEYAPDCAGELNGHDGDE
What are the official names of this protein?
Protein U7.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US22 family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: TSAD_XANOM
Sequence: MKVLGIESSCDETGVAVYDTALSGVPALRAHAVYSQIALHAEYGGVVPELASRDHVRKLLPLIRQTLGEAGVGIDELDGVAYTAGPGLVGALLVGAGVARSLAWALDVPAIGVHHMEGHLLAPLMEDDPPEPPFVALLVSGGHTQLVSVKALGSYEVLGETLDDAAGEAFDKTAKMMGLPYPGGPQLAALAETGTPGRYRFARPMTDRPGLDFSFSGLKTQVLLAWRSSDQSDTTRADIARGFEDAVVDTLVIKCLRALDAAECNTLVVAGGVGVNKRLRARLQEAAQRRGGRVCFPRPALCTDNGAMIAFAGALRLQAGERADAAVHVTPRWDMAALPPLAAGRDSGVEIREW
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF2_CHLSC
Sequence: MKRHQFQSWIFELREILREIKNSHYFLDSWTKFDAVGSFTQIFFHQERFMKLFDPRIWSILLSRDSQGSTSNRDFTIKGVVLLVVAVLIYRINNRNMVERKNLYLMGLLSIPILPIPMNSIGPRNDTLEESFWSSNINRLIVSLLYLPKGKKISESCFMDPKESTWVLPITKKCIMPESNWGSRWWRNRIGKKRDSSCKISNETVAGIEISFKEKDIKYLEFLFVSYTDDPIRKGHDCELFDRLSPRKKRNIVNLNSGQLFEILVKHLICYLMSAFREKRPIEVGGFFKQQGAEATIQSNDIEHVSHLLSRNKWGISLQNCAQFHMWQFRQDLFVSWGKNQHESDFLRNVSRENWIWLDNVWLVNKDRFFSQVRNVSSNIQYDSTRSIFVQVTDSSQLKGSSDQSRDHFDSISNEDSEYHTLINQTEIQQLKERSILWDPSFLQTERTEIESDRFPKSLSGYSSMSRLFTEREKQMNNHLLPEEIEEFLGNPTRSIRSFFSDRWSELHPGSNPTERSTRDQKLLKKQQDVSFVPSRRSENKEMVDIFKIITYLQNTVSIHPISSDPGCDMVPKDEPDMGSSNKISFLNKNPFFDFYLFHLFHDRNKGGYTLHHDFESEERFQEMADLFTLSITEPDLVYHKGFAFSIDSYGLDQKKFLNEVFNSRDESKKKSLLVLPPIFYEENESFYRRIRKKSVRISCGNDLEDPKPKIVVFASNNIMEAVNQYRLIRNLIQIQYSTYGYIRNVSNRFFLMNRSDRNFEYGIQRDQIGNDTLNHITIMKYTINQHLSNLKKSQKKWFDLLISRTERSMNRDPDAYRYKWSNGSKNFQEHLEHFVSEQKNHFQVVFDRLRMNQYSIDWSEVIDKQDLSKSLRFFLSKSLLFLSKSLLFLSKSLPFFFVSIGNIPIHRSEIHIYELKGPNDQLCNQLLESIGVQIVHLNKLKPFLLDDQYTSQRSKFLINGGTISPFLFNKTPKWMIDSFHTRNNRRKSFDNTDSYFSMISHDRDNWLNPVKPFHRSSLISSFYKANQLRFLNNPHNFWFYCHKRFPFYVEKTRINNYDLTYGQFLNILFIRNKRFSLCVGKKKHVFLERDTISPIESQVSDIFIPNDFPQSGDETYNLYKSFHFPIRSDPFVRRAIYSIADISGTPLTEEQIVNFERTYCQPLSDMNLSDSEGKNSHQYLSFNSNMSLIHTPCSEKYLPSGKRKKRSLCLKKCVEKRQMYRTFQRDSAFSNLWNLFQTYMPWFLTSTGCKYLNFTLLDTFSDPLPILSSSPKFVSIFHDIMHGSDISWPIPQKKLWVILPQWNLISEISSKCLQNLLLSEERIRRNNESPVPLIWTHLRSPNAREFLYSILFLLLVAGYLVRTHLLFVSRASSELQTELEKIKSLMIPSYMIELRKLLDRYPTSELNSFWLKNLFLVALEQLGDSLEEIRGSASGDNMLLGGGPAYGVKSIRSKKKYLNINLIDIIDLISIIPNPINRITFSRNTRHLSRTSKEIYSLIRKRKNVNGDWIDDKIESWVANSDSIDDEEREFLIQFSTLTTTEKGIDKILLSLTHSDHLSKNDSGYQMIEQPGSIYLRYLVDIHKKYLMNYEFNRSCLAERRIFLAHYQTITYSQTSCGANSSHFPSHGKPFSLRLALSPSGGILVIGSIGTGRSYLVKYLVTNSYLPFITVFPNKFDKSKGYLIDDIDIDDSDEIDIDDIDEINMDDSDEIDIDDIGEINMDDDLDTELLTRANALTMYMTPKIDRFDLTLPFELAKAMSPCIIWIPNIHDLYVNEPNYLSLGLLVNYLSRNCEICFTKNILVIASTHLPQKVDPALIAPNKLNTCIKIRRLLIPQQRKHFLILSYTRGFHLEKKMFHTNGFGSITMGSNARDLVALTNEALSISITQKKSIIDTNTIRSALHRQTWDLRSQVRSVQDHGILFYQIGRAVAQNAFLSNCPIDPISIYMKKKSCKEGDSYLYKWYFELGTSMKKLTILLYLLSCSAGSVAQDLWSPPGPDEKNWITSYGFVENDSDLVYGLLEVEGALVGSSRTEKDCSQFDNDRVTLLLRSEPRNPLDMMQNRSCSIVDQRFLYEKYESEFEEGEGEGALDPQQIEEDLFNHIVWAPRIWRPCGNLFDCIERPNELGFPYWARSFRGKRIIYHKEDELQENDSEFLQSGTMQYQTRDRSSKEQGFFRISQFIWDPADPFFFLFKDPPFVSVFSRREFFADEEMSKGLITSQTNPYPPTSLFKRWFIKNTQEKHFELLIHRQRWLRTNSSLSNGSFRSNTPSESYQYLSNLFLSNGALLDQMTKTLLRKRWLFPDEMKHLIHVTGERFPIP
What is the function of this protein?
Probable ATPase of unknown function.  Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.
What are the official names of this protein?
Protein Ycf2.
What is the protein family that this protein belongs to?
Belongs to the Ycf2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: GLSA_AKKM8
Sequence: MSDIPSNEQIRTALDNAYAYAKTVQGGKNASYIPALAQVPSDLLAIAVVTVNGDLLTAGSADAPFAIESISKAFNLAYVMDLIGMKQLRAKIGADPTGEPFNSVMAIELHGGKPLNPLVNAGAMATVSLVNGSDSDEIWGNMIHNFNNFANTALTVNQEIYKSESATNQHNRGIAWLLDSYGYFYNTPPMIVDLYTRMCSLNITASQLALMGACYANGGVNPVSKKRVVKEENVPPILAEMCMSGLYDSTGDWMYKAGLPAKSGVGGGLVAVAPGKLAMAAFSPPLDPAGNTVKGQAALQSIIRELNLNLFRS
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: RL40A_ORYSJ
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGIIEPSLQALARKYNQDKMICRKCYARLHPRAVNCRKKKCGHSNQLRPKKKIKN
What is the function of this protein?
Component of the 60S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-60S ribosomal protein L40-1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [60S ribosomal protein L40-1]: Cytoplasm.
Protein: CHLN_PROM0
Sequence: MSKVEFKKETGPREVFCGLTSIVWLHRRMPDAFFLVVGSRTCAHLIQSAAGVMIFAEPRFGTAILEEKDLAGLADAHEELDRVVNDLIERRPEIKTLFLVGSCPSEVIKLDLATVAEKLNKRFLGQVRFVNYSGSGIETTFTQGEDGALKALIPLMESSNEEKLLLVGTLANNVEDRFKKIFRNLGISNIESFPPRQSTELPKIGKNTKVLLTQPYLSDTVRDLKHRGCDIISAPFPLGIEGSTQWFLAAAKAFKIGELKVHEIISPLIKRAKLALESHKEILKGKRLFLLPESQLEISLARFLHNECEMDLIEVGTPYLNKDLMKEEINLLPDNTKIVEGQHVEKQLDRVRNSNPDLVVCGMGLANPLEAEGISTKWSIEMVFSPIHGIDQAADLAGLFSKPLKRNQILTSKTLVTH
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
Protein: NOXO1_MOUSE
Sequence: MASPRHPVSAHAVALVQMDRLQTFAFSVCWSDNSDTFVRRSWDEFRQLQKTLKKTFPVEAGLLRRSEQVLPKLPDAPLLTRRGHTGRGLVRLRLLDTYVQALLATSEHILRSSALHGFFVPKPLDLEPMLPPGSLVILPTPEEPLSQPRGSLDIHSLEAQSIPCVQPFHTLDIRDRPFHTKAQEILDILLRHPSGWWLVENKDQQVAWFPAPYLEEVATCQGQESGLALQGSGRQFCTTQAYEGSRSDELSVPSGARVHVLETSDRGWWLCRYNGRTGLLPAMSLQPEGLGSLLGRPGFPDSAGADKVAEDRTIPPVVPTRPCMSAIQSRCCSITRRALGQEQGTRVPR
What is the function of this protein?
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.  Isoform 3 is more potent than isoform 1 in activating NOX3.  Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
What are the official names of this protein?
NADPH oxidase organizer 1, Nox organizer 1, Sorting nexin-28.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with the plasma membrane in a lipid-dependent manner.
Protein: DCD_GLAP5
Sequence: MRLCDKDIERYLDEGIISLTPRPSNEKISGATIDVRLGNSFRVFREHSTPYIDLSGPREEMTAQLNRVMSDEILIADDEAFFLHPGELALATTLESVKLPANIVGWLDGRSSLARLGLMVHVTAHRIDPGWEGKIVLEFFNAGKLPLALRPNMAIGALSFEILSGYAEHPYNARKDAKYKNQQSAVFSRIDKDE
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: CSEB_STRCO
Sequence: MADQTHVLFVEDDDVIREATQLALERDGFAVTAMPDGLSGLESFRADRPDIALLDVMLPGLDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGAVLVARIRAVLRRFGHAGGGDRTEGAGAAETGGVLTFGDLEVDTDGMEVRRAGRPVGLTPTEMRLLLEFSSAPGTVLSRDKLLERVWDYGWGGDTRVVDVHVQRLRTKIGQDRIETVRGFGYKLKA
What is the function of this protein?
Member of the two-component regulatory system CseB/CseC involved in the stability of the cell envelope.  CseB activates transcription of RNA polymerase sigma-E factor, in response to changes in the cell envelope.
What are the official names of this protein?
Transcriptional regulatory protein CseB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANT_SALNS
Sequence: MSTSTQNIPWYRHLNRAQWRAFSAAWLGYLLDGFDFVLIALVLTEVQSEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVSSIILFSVGTLACGFAPGYTTMFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSVGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNIPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILMTFAAAAALWFCFAGNLQNAAIVAGLGLLCAVIFISFMVQSSGKRWPTGVMLMLVVLFAFLYSWPIQALLPTYLKTELAYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLASQILIIPVFAIGGTNVWVLGLLLFFQQMLGQGIAGILPKLIGGYFDTDQRAAGLGFTYNVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRWLRPEALRTHDAIDDKPFSGAVPLGSGKGAFVKTKS
What is the function of this protein?
Catalyzes the proton-dependent transport of sialic acid.
What are the official names of this protein?
Sialic acid transporter NanT, Sialic acid permease, Sialic acid/H(+) symporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURA_MYCSM
Sequence: AIADGTSMITENVFEARFRFVEEMIRLGADARTDGHHAVVRGIPQLSSAPVWSSDIRAGAGLVLAGLVADGETEVHDVFHIDRGYPLFVENLVSLGAEIERVSS
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHAT2_AMABI
Sequence: MSDINATRLPAWLVDCPCVGDDVNRLLTRGE
What is the function of this protein?
Major toxin that belongs to the bicyclic heptapeptides called phallotoxins (PubMed:18025465).  Although structurally related to amatoxins, phallotoxins have a different mode of action, which is the stabilization of F-actin (PubMed:18025465).  Phallotoxins are poisonous when administered parenterally, but not orally because of poor absorption (PubMed:18025465).
What are the official names of this protein?
Phallacidin proprotein 1.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: TOLB_ECOBW
Sequence: MKQALRVAFGFLILWASVLHAEVRIVIDSGVDSGRPIGVVPFQWAGPGAAPEDIGGIVAADLRNSGKFNPLDRARLPQQPGSAQEVQPAAWSALGIDAVVVGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYAGHTASDEVFEKLTGIKGAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKFPAWSPYL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: YIDD_NITMU
Sequence: MIIAFIRLYQYCLSPFLGPSCRFSPSCSHYACEALARHGATRGLVLSVWRIMRCNPWSRGGYDPVPAEPFR
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RNZ_STRPZ
Sequence: MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRSFQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLEGTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYGKGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKMVQDLEEVII
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: CITE_KLEPN
Sequence: MKPRRSMLFIPGANAAMLSTSFVYGADAVMFDLEDAVSLREKDTARLLVYQALQHPLYQDIETVVRINPLNTPFGLADLEAVVRAGVDMVRLPKTDSKEDIHELEAHVERIERECGREVGSTKLMAAIESALGVVNAVEIARASPRLAAIALAAFDYVMDMGTSRGDGTELFYARCAVLHAARVAGIAAYDVVWSDINNEEGFLAEANLAKNLGFNGKSLVNPRQIELLHQVYAPTRKEVDHALEVIAAAEEAETRGLGVVSLNGKMIDGPIIDHARKVVALSASGIRD
What is the function of this protein?
Represents a citryl-ACP lyase.
What are the official names of this protein?
Citrate lyase subunit beta, Citrase beta chain, Citrate (pro-3S)-lyase subunit beta, Citryl-CoA lyase subunit.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3L24_OPHHA
Sequence: TKCYKTGDRIISEACPPGQDLCYMKTWCDVFCGTRGRVIELGCTATCPTVKPHEQITCCSTDNCNPHPKMKQ
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin 4, Alpha-neurotoxin.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y4SH_SINFN
Sequence: MEKCSHESGRHSAENDGKYDITGSTATNVVDGFTMVAVGDVIVSRTLANGHHPGFSEIVELLRAADVTFGNMETLIFDIRSFNGTPQAEYGGAYHVSLPEIGPDLKAMGFNIMGRANNHSLDWGVEGMRETSRILDESGIIHAGVGESRAQASAARLLETARGRVALLSCATSFTPMSRACDPAGEAPARPGVNALRLERSVVVEPDMLESLRKIRDALPNPGPKHDDREMLVLAGTTYRTGKDVGYTYAANTRDLADILRNVRRGKQYSDFCIFTNHAHEPGNWSEEPADFEQALARKLIDAGADAYVGHGPHRLRGIEIYKRRPIFYSLGNFFYDDLRTPVGADMYDVYDKDPQVDTDAEVTAAEETMGYPTAAGFIGALAEPVYYESVVAVSRFEENQLAELRLYPIELGYSKRLANRGVPSLAPRPQAISILERLQRLSEPFGTRITIEDRVGLIRL
What is the function of this protein?
Could be involved in the biosynthesis of a cell wall component.
What are the official names of this protein?
Uncharacterized protein y4sH.
What is the protein family that this protein belongs to?
Belongs to the CapA family.