PharMolix/UniProtQA huggingface dataset:
Protein: S3AD_KLEPN
Sequence: MREAVIAKVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDIDLLVTVTVRLDETTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPATIDIDLAILLTKAREHSVALVGPAAEELFDPVPEQDLFEALNETLTLWNSPPDWAGDERNVVLTLSRIWYSAVTGKIAPKDVAADWAMERLPAQYQPVILEARQAYLGQEDRLASRADQLEEFVHYVKGEITKVVGK
What is the function of this protein?
Mediates bacterial resistance to the antibiotics streptomycin and spectinomycin.
What are the official names of this protein?
Aminoglycoside (3'') (9) adenylyltransferase, Streptomycin 3''-adenylyltransferase.
Protein: MAEL_DROER
Sequence: MAPKKHSAFMVFVTEWRNHNVEGRRMTLPQAVSHCGTIWEKMTAQQRGPYQSGAKDADVADRAKRERLNCHGQGIAQVDQVQKEAAESLMHMKRSTERLVINAKKSHDLENAKFVFATFNYFTKALTTDVYVPAEFAACEYSLKEGIRSIYSSMIDPGQIIFGQGSDALHHSSTTHDLPLPPNALGEKNMAKLYRNIIDYLTKCQGGDKPLIVFTPAENIAMVKSCFRYLECEDDSKDGGRTIQVFDIEYLLFILKKEVMDVADLNDEKINKFVTDAFFKKDFFEFTAGIACQYHEDNDRTKYCTQSMVTRWAYTFSDFMCGDLAITVQPGKHIPAHTKPNYRIISSDASSLAHESSFDSFYSLPGSRVKKENQSEDVLLSSSRPSVESSSYTPTDHTAFTADLSKLCEFPSLGMRNSSKHRGLDVSAQRERNAGAWNLPTHSRSIQKFSDNDFSVTGADGKHKN
What is the function of this protein?
Involved both in the piRNA and miRNA metabolic processes.  As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons.  As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam).  Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
What are the official names of this protein?
Protein maelstrom.
What is the protein family that this protein belongs to?
Belongs to the maelstrom family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein: RSV2_SCHPO
Sequence: MDTTNNTYARSISSNGNDNFPTPDWQFNGSQLQQNRKSKMNGRSVTNVFPNAFSDAEFEQISMPELNLKRFNPTTLEENNSDLSDMSSWDYMMNVPIRVYNDADTMDPFSLDTIPDSSMDMPFDPLASDYGNAANFPSVPSSLGSNHQFITTPPVNGSNEPTSAQTNHIITANSSPSGNAGSNASASMSVPPPLTPSASTINDQPFSNSFDLPSQVIADGTGAISDINGNPFPMNSPPLDMEPLPSISMDASDSVSEQLVKDASLPSGPFSTDYLENGSDLKRSLGHNQKSDRVSKDVSPQHQANPSTLNNPLKTQNFDSSKNLYTDNKDSSLVSPTGLQSRMEQNPEVRAHPMKDSATSTALRRSHALGAAADSLLPQENSAQIYDGKDVSMVNDNMHSDVRQDSFNKESIKQRIPSLSPPITRSYNAKHRPSLVLGTSVNPHSLSPSQPPVVVPSNTTISSSPPLTSPVKTSANIPNLLPTSELDSSNAPHSQSAATHDLNDVKSYYNTRSSHSVVPNPTNQKVSITGAAADGPNGSAPVDTTPTNSSTTATGAQRKRRKFKFGKQIGPVRCTLQNRVTGEICNTVFSRTYDLIRHQDTIHAKTRPVFRCEICGDQRHFSRHDALVRHLRVKHGR
What are the official names of this protein?
Zinc finger protein rsv2, Required for stationary phase viability protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: IKKA_XENLA
Sequence: MERPPVQHGAVCGPWDMKDRLGTGGFGNVCLYQNRETGELKAIKSCRLELSVKNKERWCQEIQIMKRLNHPNVVKACDVPPEMDFLVNDVPHLAMEYCAGGDLRKLLNKPENCCGLKESQVLNLISDIGSGIQYLHENRIIHRDLKPENIVLQECNGKTVHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELFENKPYSVTVDYWSFGTMAFECIAGFRPFLHNMQPFTWHEKIKKKDHKHIYAYEEMSGEIRFSTSLPEPNNLCSIIVDKIETWLQLLLNWDPVQRGGGIDCGRPRCFMLMDQIFSLKIVHILNMTSAKIHSFHLQPEESLHTLQSRIERETGISTCNQELLLEMGVSLDPRKPASQCVIDGVKGWDSYMVYLFDKSKTVYEGPFQSRSLSECLNYIVQDSKVQLPIPQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRFNTNLTKMKNTMVSASQQLDAKLQFFKRSIEIDLERYSDQMAYGISSEKMLRAWKEMEDKAVCFGKAGEIHFLDETIMGLHTEIVELQRSPCARRQGDVMEHLEQRAMELYKQLKPRSPDKAYSDSTEMVKILVQTVQGQDRVLKELFGHLSKLLGCKQKIIDLLPQIEMTVNNIKEADSSLMQMQAKRQREIWHLLKIACTQSSTRSLVTASGETPITSRTSAWSDQSSPQALFSMLTSKDKGREILRHTIDKNTDYQKLLSNLILQTQTTMEQTSLMSMDFSWLNQ
What is the function of this protein?
Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor.  Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
What are the official names of this protein?
Inhibitor of nuclear factor kappa-B kinase subunit alpha, I kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, Conserved helix-loop-helix ubiquitous kinase, Nuclear factor NF-kappa-B inhibitor kinase alpha, NFKBIKA.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
Protein: TARA_BACSH
Sequence: MQTKPINQLDFVDSELTSFVSHLETTYLDQNKGAFIVTANPEIGFEAMQNPRYEAVLSSADFILPDGIGVVMVSKLIGKPLQSRIAGYDLFTSLLDKADQKKKRVFFYGAAKHVIAETIERVKRDFPGIEIAGYSDGYVKDQREVADKIAASTPDMVFVALGYPNQEFFIHKYRHLFPQAVAVGLGGSFDVFSGNVKRAPSFFIRFHLEWMYRLLTNPARWRRMLSIPKYVTAVLKHERASAKPHYTGQVKDQSRHL
What is the function of this protein?
Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.
What are the official names of this protein?
N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase, N-acetylmannosaminyltransferase, UDP-N-acetylmannosamine transferase, UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
Protein: DV4H_CATRO
Sequence: MPKSWPIVISSHSFCFLPNSEQERKMKDLNFHAATLSEEESLRELKAFDETKAGVKGIVDTGITKIPRIFIDQPKNLDRISVCRGKSDIKIPVINLNGLSSNSEIRREIVEKIGEASEKYGFFQIVNHGIPQDVMDKMVDGVRKFHEQDDQIKRQYYSRDRFNKNFLYSSNYVLIPGIACNWRDTMECIMNSNQPDPQEFPDVCRDILMKYSNYVRNLGLILFELLSEALGLKPNHLEEMDCAEGLILLGHYYPACPQPELTFGTSKHSDSGFLTILMQDQIGGLQILLENQWIDVPFIPGALVINIADLLQLITNDKFKSVEHRVLANKVGPRISVAVAFGIKTQTQEGVSPRLYGPIKELISEENPPIYKEVTVKDFITIRFAKRFDDSSSLSPFRLNN
What is the function of this protein?
Catalyzes the C4-hydroxylation of desacetoxyvindoline.
What are the official names of this protein?
Deacetoxyvindoline 4-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EIF3I_DROSE
Sequence: MRPLMLQGHERSITQIKYNREGDLLFSCSKDQKPNVWYSLNGERLGTYDGHQGAVWCLDVDWESRKLITGAGDMTAKIWDVEYGTVIASIPTKSSVRTSNFSFSGNQAAYSTDKAMGQSCELFLIDVRNADSSLSEQEPTLRIPMTESKITSMLWGPLDETIITGHDNGNIAIWDIRKGQKVVDSGTDHSAGINDMQLSKDGTMFVTASKDTTAKLFDSESLMCLKTYKTERPVNSAAISPIMDHVVLGGGQDAMEVTTTSTKAGKFDSRFFHLIYEEEFARLKGHFGPINSLAFHPDGKSYASGGEDGFVRVQTFDSTYFENIFE
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit I, eIF3i, Eukaryotic translation initiation factor 3 subunit 2, TRIP-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit I family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARR17_ARATH
Sequence: MNKGCGSGSDSCLSSMEEELHVLAVDDNLIDRKLVERILKISSCKVTTAENGLRALEYLGLGDPQQTDSLTNVMKVNLIITDYCMPGMTGFELLKKVKESSNLKEVPVVILSSENIPTRINKCLASGAQMFMQKPLKLSDVEKLKCHLLNCRS
What is the function of this protein?
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Type-A response regulators seem to act as negative regulators of the cytokinin signaling (By similarity).
What are the official names of this protein?
Two-component response regulator ARR17.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-A subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: NS12_CVBLS
Sequence: MDIWKPEIKYLRYTNGFNVSELEDACFKFNYKFPKVGYCRVPSHAWCRNQGSFCATLTLYGKSKHYDKYFGVITGFTAFANTVEEAVNKLVFLAVDFITWRRQELNVYG
What are the official names of this protein?
Non-structural protein of 12.7 kDa, ns12.7, 12.7 kDa accessory protein.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses ns12.7 protein family.
Protein: FABA_VIBC1
Sequence: MQNKRDSYTREDLLASSQGELWPQGPQLPAPNMLMMDRITKMSETEGDFGKGLILAELDITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLGWVGGKGKGRALGVGEVKFTGQILPTAKKVTYEIHMKRVVNRKLVMGLADGRVCVDGKEIYVAKDLKVGLFQDTSSF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVSSA_CAEBR
Sequence: MQEDVYRSGIRKNLNRILQELTDDGKLDFESVPYQNLKAEIEKRDEECTEVLCKVLLETASRSGCADRQFVLQLFNEYFCNSSLFRDQILNDPKEFIEIMLETDPIRNPLPGSKSEGNELKSKSLAFIKNWEKMYAKNDARMKCLAVTLRKTKFVDYENGEKKIEEERKRREFLDERRRMIVERTLSLYKSKFEEIKEDVERLKMELETTMEMLVPSFTNSDDVDIPMDIPSTSSKSFELVIEDLSPLIKVNADNDAIVEAFLGAKTVLIHRVQTMRKLAKGLLPLKGAGESLAQSIIDYRDVIKKLVLKADEIRIKTKKKPVQKAKKFDDDFIDVEISIDDILMVQYANEASEDVKEDVKEPEKKLANPKKEEPKVKFVSFGLDLKYWGEERKDVEVPKNNADCHRFWRSADESTVAGTVHDTVYTQRQFTFVGEAPKIDRECLAKLPSGALCKRKDMFKCPLHGPLVDRDANGKPVKDEDRLKEIDRKERKRLKEAEEFSRKIVKEYESKTKRKRKHEEETSVRSRLQKKLFDPKTIQRVSADITSQQRSRLEKNFSHQFSHL
What is the function of this protein?
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage.  TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes.
What are the official names of this protein?
UV-stimulated scaffold protein A homolog.
What is the protein family that this protein belongs to?
Belongs to the UVSSA family.
What are the subcellular locations of this protein?
Chromosome. Note=Accumulates at UV DNA damage sites.
Protein: GATA2_ARATH
Sequence: MDVYGLSSPDLLRIDDLLDFSNEDIFSASSSGGSTAATSSSSFPPPQNPSFHHHHLPSSADHHSFLHDICVPSDDAAHLEWLSQFVDDSFADFPANPLGGTMTSVKTETSFPGKPRSKRSRAPAPFAGTWSPMPLESEHQQLHSAAKFKPKKEQSGGGGGGGGRHQSSSSETTEGGGMRRCTHCASEKTPQWRTGPLGPKTLCNACGVRFKSGRLVPEYRPASSPTFVLTQHSNSHRKVMELRRQKEVMRQPQQVQLHHHHHPF
What is the function of this protein?
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.  May be involved in the regulation of some light-responsive genes.
What are the official names of this protein?
GATA transcription factor 2, AtGATA-2.
What is the protein family that this protein belongs to?
Belongs to the type IV zinc-finger family. Class A subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYB_BALRE
Sequence: MAPNLRKSHPLLKMINNSLIDLPTPSNISVWWNFGSLLGICLTTQILTGLLLAAHYTADTTLAFSSVAHTCRNVQHGWLIRNLHANGASFFFICIYMHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTIVEWAWGGFSVDNPTLTRFFTLHFLLPFMIMGLTLIHLTFLHESGSNNPLGIVSNCDKIPFHPYFSLKDTLGFMLMFLPLMTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYGFLRSIPNKLGGVLALAASMLILFLAPLLHKSKQRTMTFRPLSQLLFWTLTANLLILTWVGSQPVEHPFIIIGQLASLTYFTILLILFPMTGALENKMLNY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SPSY_HUMAN
Sequence: MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP
What is the function of this protein?
Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
What are the official names of this protein?
Spermine synthase, SPMSY, Spermidine aminopropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
Protein: NTF2_MOUSE
Sequence: MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG
What is the function of this protein?
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport.  Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport.  Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
What are the official names of this protein?
Nuclear transport factor 2, NTF-2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.
Protein: ATG13_MOUSE
Sequence: METELSSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKALSGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLNGLGEGFQTVRVGTVGTPVGTLTLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAEDAGVAYPSVEDSQEVCTTSFSTSPPSQLSSSRLSYQPAVLGLGSADLAYPVVFTAGLNTTHAHQLMVPGKEGGVTLAPSHPTHGAQADPERLVMHMPSDGTHCAATPSSSEDTETVSNSSEGRASPHDILETIFVRKVGAFVNKPINQVTVTSLDIPFAMFAPKNLELEDADPMVNPPESPETTSPLHGSLHSDGSSGGSGGSTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDFGAQSMAEDLDSLPEKLAVHEKNVREFDAFVETLQ
What is the function of this protein?
Autophagy factor required for autophagosome formation and mitophagy.  Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.  Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
What are the official names of this protein?
Autophagy-related protein 13.
What is the protein family that this protein belongs to?
Belongs to the ATG13 family. Metazoan subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
Protein: PSAJ_ACAM1
Sequence: MGDVPLKIDSEKDFMKFFSTAPVIALVFFTLTAGFLVELNRFFPDILFFPY
What is the function of this protein?
May help in the organization of the PsaE and PsaF subunits.
What are the official names of this protein?
Photosystem I reaction center subunit IX.
What is the protein family that this protein belongs to?
Belongs to the PsaJ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: UPPP_CAMC5
Sequence: MDIVHIIVLSLVQGITEFLPISSSAHLVLVPKLLGWPDQGLAFDVAVHIGTLTAIVFYFKDSIFGLLRDFFVSIVRRERVGDSTLVWAVCFATIPAGIFGLAFNSLIEEYTRSGIVIAVTTIIFGVVLYLADKRVGTKSEYDVTIKLALIIGLAQALALIPGVSRSGITMSAALFLGFSRVGSANFSFLMSIPIILLAGGLESVKLIRHDISYVWSDLALAALISAVSAYICVKLFMSIISKMSMTPFVVYRLILGVFLLFIFV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KATG1_IDILO
Sequence: MTKSSGGGKCPIMHGSMTSEKKTNTHWWPNSLKLEILRQHDTKANPLDEDFNYAEEFKKINLEELKQDLKNFMTDSQEWWPADWGHYGGLMIRMAWHSAGSYRLADGRGGGGTGNQRFAPLNSWPDNVSLDKARRLLWPIKKKYGNKLSWADLFILAGNMAYESMGLKTFGFAGGREDIWHPEEDTYWGSEKEWLAETKNRYSSDEERDSLENPLAAVQMGLIYVNPEGVDGNPDPLRTAKDVRETFKRMAMNDEETCALTAGGHTVGKCHGNGKEENLGPEPEAADVEEQGMGWRNSGGKGVGRDTMSSGIEGAWTTNPTQWDNGYFYLLFNYEWELKKSPAGAWQWEPIDIKEEDKPVDVEDPSIRHNPIMTDADMAMKMDPDYRKIAEKFYKDPEYFADVFARAWFKLTHRDLGPKDRYLGADVPEEDLIWQDPIPKVDYSLSEQEIADLKEKLLNTELTSYELISTAWDSARNFRCSDFRGGANGARIRLAPQKDWHGNEPEKLHKVLRVLEDLQSTLDKKVSLADLIVLGGTAAVEKAAKDAGYNVTVPFAPGRGDATDEQTDVESFEPLEPLHDGYRNYLKKDYAVPAEELMLDRTHLMGLTAPEMTVLVGGMRALGANYGESEHGVFTDRVGTLTNDFFVNLTDMNNVWKKADDHYEVRDRKTDELKWTASRIDLVFGSNSILRSYSELYAQDDNQEKFVKDFVKAWTKVMNADRFDL
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase 1, CP 1, Peroxidase/catalase 1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RPOA_CLOPS
Sequence: MLEIEKPVIQCVESNDNGTYGKFEIEPLERGYGITLGNALRRILLSSLPGVAPTSVKIDSVLHEFSTITGVKEDVTEIILNLKMLALTMEGEGPKTIYIDAQGPGVVTGADIKTDGDVEVVNKDLHIATLDNDGKLYMEIVVNRGRGYVTQNKNKTEDLPLSAIAIDSIYTPVKRVNFSVQNTRVGQITDYDKLTLEIWTNGTIRIEEAISLSAKILIEHFKLFMTLTDNANDVEIMIEKEEDKKEKALEMTIEELDLSVRSYNCLKRAGINTVQELAGKSMDDMMKVRNLGKKSLEEVERKLNELGLNLRLNDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: SYC_STRMU
Sequence: MIKIYDTLTRSLREFVPIHENTVNMYVCGPTVYNYIHVGNGRSAIAFDTIRRYFEYRGYTVNYISNFTDVDDKIIKAAAKAGMTTKALSDKFIAAFKEDVAALGVKPATENPRVIDYMQDIIDFVQILVDKGFAYESSGDVYFRVRKSDNYAALANKTLEELEIGASGRVDAESDCKEDPLDFALWKAAKEGEIAWDSPWGAGRPGWHIECSVMATTILGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKKFANYWMHNGFVNIDNEKMSKSLGNFITVHDALKTMDGQVLRFFFATQHYRKPFNFTEKAIRDAEINLKYLKNTYEQPFTATVDEAVFARFLEKFQAAMDEDFNTANGITVVFELAKWINSGHYDQTVKDKFAEILQIFGVVFKEEVLDAEIEKLIEERQKARAARDFTKADAIRDDLAAQGIKLLDTKDGVRWMRD
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JZT1B_CHIGU
Sequence: MKTSILFVIFSLALLFALSAATEIEETDRACGQFWWKCGEGKPPCCANFACKIGLYLCIWSP
What is the function of this protein?
Moderately inhibits voltage-gated sodium channels and weakly inhibits voltage-gated potassium channel (PubMed:17150181, PubMed:17618665, PubMed:23246579, PubMed:26721415).  Inhibits the inactivation of rat Nav1. 2/SCN2A (IC(50)=870 nM), rat Nav1. 3/SCN3A (IC(50)=845 nM), rat Nav1. 4/SCN4A (IC(50)=339 nM), human Nav1. 5/SCN5A (IC(50)=335 nM) and human Nav1. 7/SCN9A sodium channels (IC(50)=348 nM) (PubMed:26721415).  The toxin delays the inactivation of sodium channels without affecting the activation and steady-state inactivation kinetics in the physiological range of voltages (PubMed:26721415).  Site-directed mutagenesis of the sodium channel indicates that the toxin interacts with site 3 located at the extracellular S3-S4 linker of domain IV (PubMed:26721415).  On potassium channels, it inhibits activation of channels with an IC(50) of 8. 05 uM through a voltage sensor-trapping mechanism (PubMed:23246579).  It increases muscle contraction in several assays (mouse phrenic nerve-diaphragm, toad heart, rat vas deferens) and is suggested to act both presynaptically and postsynaptically (PubMed:17618665).
What are the official names of this protein?
Delta-theraphotoxin-Cg1a 2, Delta-TRTX-Cg1a, Jingzhaotoxin-1.2, JZTX-1.2, Jingzhaotoxin-I.2, JZTX-I.2, Peptide F5-24.92.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 33 (Jztx-1) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL2_ECOBW
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: KDSB_ACISJ
Sequence: MSRAAPFTVLIPARLASTRLPNKPLADIAGLPMVVHVARRASQSGAQRCVVAADDARIVQACQAHGVQALLTRADHASGSDRLAEACELLGLAGEDIVVNVQGDEPLIDPRLIDAVAALLHARGDASMGTAAHAIDSAEDFANPNVVKVVLDAQGLAHYFSRAPIPHARDHAPGSLWWQPGQTGVPVGFAPLRHIGIYSYRAGFLRRFPQLPAAPTEQLEALEQLRALWHGHRIAVHVTGSAPGAGVDTPADLERVRTLLGG
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.