PharMolix/UniProtQA huggingface dataset:
Protein: PHS_RHOPT
Sequence: MNRLSASERQAALRELPGWLELEEREAIGRSYQFTDFSEAFGFMTRVALAAEKADHHPEWRNVYRTVDVVLTTHDAGGVTERDVKLAKAMDAIAERCGAR
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: FOLD_DICT6
Sequence: MGVILEGKPVAEKLEKEIKEKIEIYKTKGIIPNLCIVKVGENEEAEAYAKSIERFFSRIGINVERKNFAENVSLLEFQKALKELEKNNKVHGILILRPLSEELERQKAFRFLSPDKDVEGITYENLGKLFVGEKCFHPCTPQAVIELLDFYKISVEGKDVVVVGRSISVGKPLSILLLNRNATVTICHSKTKNLEELTRRAEVLVAAVGRPHFIGKDMVKEGQVVIDIGTNVVEGKLVGDVNFEEVKDKVGYITPVPGGIGIITTRVLAMNLLKAVEKNEARN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: DEOB_LACLS
Sequence: MPKKFGRIHLVVMDSVGIGAAPDADKFFNHDVETHEAINDVKSDTIGHISEIRGLDVPNLQKLGWGNIPRESPLKTIPAAQKPAAYVTKLEEISKGKDTMTGHWEIMGLNIQTPFPTYPEGYPEDLLEKIEEFSGRKIIREANKPYSGTAVIEDFGPRQLETGELIIYTSADPVLQIAAHEDVISREELYKICEYVRSITLEGSGIMIGRIIARPYVGEAGNFERTDGRRDYALSPFAETVLEKLYKAGIDTYSVGKISDIFNTVGVKYDMGHNHNDMDGVDRLLKAMTKTEFTEGFSFTNLVDFDAKYGHRRDVEGYGKAIEDFDGRLPEIIDAMNEDDLLMITADHGNDPSYVGTDHTREYIPLVIFSKSFKEPKVLPVGHFADISATIAENFSVKKAQTGESFLDALV
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECG_STAAM
Sequence: MAKVNLIESPYSLLQLKGIGPKKIEVLQQLNIHTVEDLVLYLPTRYEDNTVIDLNQAEDQSNVTIEGQVYTAPVVAFFGRNKSKLTVHLMVNNIAVKCIFFNQPYLKKKIELNQTITVKGKWNRVKQEITGNRVFFNSQGTQTQENADVQLEPVYRIKEGIKQKQIRDQIRQALNDVTIHEWLTDELREKYKLETLDFTLNTLHHPKSKEDLLRARRTYAFTELFLFELRMQWLNRLEKSSDEAIEIDYDLDQVKSFIDRLPFELTEAQKSSVNEIFRDLKAPIRMHRLLQGDVGSGKTVVAAICMYALKTAGYQSALMVPTEILAEQHAESLMALFGDSMNVALLTGSVKGKKRKILLEQLENGTIDCLIGTHALIQDDVIFHNVGLVITDEQHRFGVNQRQLLREKGAMTNVLFMTATPIPRTLAISVFGEMDVSSIKQLPKGRKPIITTWAKHEQYDKVLMQMTSELKKGRQAYVICPLIESSEHLEDVQNVVALYESLQQYYGVSRVGLLHGKLSADEKDEVMQKFSNHEIDVLVSTTVVEVGVNVPNATFMMIYDADRFGLSTLHQLRGRVGRSDQQSYCVLIASPKTETGIERMTIMTQTTDGFELSERDLEMRGPGDFFGVKQSGLPDFLVANLVEDYRMLEVARDEAAELIQSGVFFENTYQHLRHFVEENLLHRSFD
What is the function of this protein?
Critical role in recombination and DNA repair.  Helps process Holliday junction intermediates to mature products by catalyzing branch migration.  Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity.  Unwinds branched duplex DNA (Y-DNA) (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase RecG.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecG subfamily.
Protein: SPEE1_HYPBU
Sequence: MELGMFRLNIYQPGGPIGALYPVEKILYHGRSQYQEIMILVLRGFGKTLVLDGLIQSTESDEHIYHETLVHPAMTVHPNPRRVLILGGGEGATLREVLKHNTVEKAVMVDIDGEVVRVAREYLPEWHQGAFDDPRAQVVIMDGFEYIKEAARRGEDFDVIIMDLTDPFGPKIAAKLYTKEAIGLVKSVLRSDGILVTQAGCAALFPEAFEKVYGSVKSLFAHAEEYGVWVPSFMYVNSFVFASDKYRLTDLSMEEVDRRLRERGVETRFYSGLRHYTLIGLGGIRLLEGRGS
What is the function of this protein?
Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions.  It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively.  Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine, spermidine and norspermine to yield norspermine, thermospermine and caldopentamine, respectively.  It can also synthesize sym-norspermidine (bis(3-aminopropyl)amine) from 1,3-diaminopropane with a very low activity.  The biosynthesis of caldohexamine and caldoheptamine from caldopentamine has been also observed.
What are the official names of this protein?
Polyamine aminopropyltransferase 1, Caldopentamine synthase, Norspermidine aminopropyltransferase, Norspermine aminopropyltransferase, Norspermine synthase, Spermidine aminopropyltransferase, Thermospermine synthase, Triamine/tetramine aminopropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_YERPN
Sequence: MSEFVTVARPYAKAAFDFAVEHQAVERWQNMLAFTAQVTRNEQIAELLSGAVAPETMSTTFIAVCGDQLDEPAQNFIRVMAENGRLLVLPEVLQQFIQLRASLESTVDVEVSSARALNDEQLAKIAAAMEKRLSRKVKLNCKIDKSVMAGVVIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CAPSD_TBSVC
Sequence: MAMVKRNNNTGMIPVSTKQLLALGAAAGATALQGFVKNNGMAIVEGAVDLTKRAYKAVRRRGGKKQQMINHVGGTGGAIMAPVAVTRQLVGSKPKFTGRTSGSVTVTHREYLSQVNNSTGFQVNGGIVGNLLQLNPLNGTLFSWLPAIASNFDQYTFNSVVLHYVPLCSTTEVGRVAIYFDKDSEDPEPADRVELANYSVLKETAPWAEAMLRVPTDKIKRFCDDSSTSDHKLIDLGQLGIATYGGAGTNAVGDIFISYSVTLYFPQPTNTLLSTRRLDLAGALVTASGPGYLLVSRTATVLTMTFRATGTFVISGTYRCLTATTLGLAGGVNVNSITVVDNIGTDSAFFINCTVSNLPSVVTFTSTGITSATVHCVRATRQNDVSLI
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.
What are the official names of this protein?
Capsid protein, Coat protein, p41.
What is the protein family that this protein belongs to?
Belongs to the icosahedral plant coat protein family.
What are the subcellular locations of this protein?
Virion.
Protein: UNG_FRATN
Sequence: MTWSDILAEEKQQPYFKQILDFLACESANGKVIFPAKENIFNAFKYTELDNLKVVILGQDPYHNYNQAHGLAFSVQKGVDIPPSLQNIYKELARSIPEFKIPNHGYLVDWAKQGVFLLNTTLTVEAHKANSHKDIGWETFTDTVISKISENKHNVVFMLWGSHARKKKVLIDSSRHLILESTHPSPLSAHRGFLGCNHFVDCNKYLIEKKSQKIDWNLLC
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHS2_SECCE
Sequence: MAATMTVEEVRKAQRAEGPATVLAIGTATPANCVYQADYPDYYFKITKSDHMADLKEKFKRMCDKSQIRKRYMHLTEEILQDNPNMCAYMAPSLDARQDIVVVEVPKLGKAAAQKAIKEWGQPRSKITHLVFCTTSGVDMPGADYQLTKMLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNRGARVLVVCSEITAVTFRGPHESHLDSLVGQALFGDGAAAVIIGADPDESIERPLFQLVSASQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIERALEDAFKPLGIDDWNSVFWIAHPGGPAILDMVEAKVNLNKERMRATRHVLSEYGNMSSACVLFIMDEMRKRSAEDGHTTTGEGMDWGVLFGFGPGLTVETVVLHSVPVTA
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 2, Naringenin-chalcone synthase 2.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: RETST_MOUSE
Sequence: MWITALLLAVLLLVILHRVYVGLYAASSPNPFAEDVKRPPEPLVTDKEARKKVLKQAFSVSRVPEKLDAVVIGSGIGGLASAAVLAKAGKRVLVLEQHTKAGGCCHTFGENGLEFDTGIHYIGRMREGNIGRFILDQITEGQLDWAPMASPFDLMILEGPNGRKEFPMYSGRKEYIQGLKKKFPKEEAVIDKYMELVKVVARGVSHAVLLKFLPLPLTQLLSKFGLLTRFSPFCRASTQSLAEVLQQLGASRELQAVLSYIFPTYGVTPSHTAFSLHALLVDHYIQGAYYPRGGSSEIAFHTIPLIQRAGGAVLTRATVQSVLLDSAGRACGVSVKKGQELVNIYCPVVISNAGMFNTYQHLLPETVRHLPDVKKQLAMVRPGLSMLSIFICLKGTKEDLKLQSTNYYVYFDTDMDKAMERYVSMPKEKAPEHIPLLFIAFPSSKDPTWEERFPDRSTMTALVPMAFEWFEEWQEEPKGKRGVDYETLKNAFVEASMSVIMKLFPQLEGKVESVTGGSPLTNQYYLAAPRGATYGADHDLARLHPHAMASIRAQTPIPNLYLTGQDIFTCGLMGALQGALLCSSAILKRNLYSDLQALGSKVKAQKKKM
What is the function of this protein?
Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol (PubMed:15358783, PubMed:17253779, PubMed:19139408).  Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers (PubMed:15358783).  May play a role in the metabolism of vitamin A (PubMed:15358783, PubMed:17253779).  Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP (PubMed:28855500).  Required for adipocyte differentiation in a 3T3-L1 cell culture model (PubMed:19139408).  This effect seems not to mimic the in vivo situation in which animals show increased adiposity in the absence of RETSAT (PubMed:19940255).
What are the official names of this protein?
All-trans-retinol 13,14-reductase, All-trans-13,14-dihydroretinol saturase, RetSat, PPAR-alpha-regulated and starvation-induced gene protein.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: PR1B_TOBAC
Sequence: MGFFLFSQMPSFFLVSTLLLFLIISHSSHAQNSQQDYLDAHNTARADVGVEPLTWDNGVAAYAQNYVSQLAADCNLVHSHGQYGENLAQGSGDFMTAAKAVEMWVDEKQYYDHDSNTCAQGQVCGHYTQVVWRNSVRVGCARVKCNNGGYVVSCNYDPPGNVIGQSPY
What is the function of this protein?
Probably involved in the defense reaction of plants against pathogens.
What are the official names of this protein?
Pathogenesis-related protein 1B, PR-1B.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Vacuole. Note=Accumulates in within the vacuoles of specialized cells known as crystal idioblasts.
Protein: OBI1_PONAB
Sequence: MAQTVQNVTLSLTLPITCHICLGKVRQPVICINNHVFCSICIDLWLKNNSQCPACRVPITPENPCKEIIGGTSESEPMLSHTVRKHLRKTRLELLHKEYEDEIDCLQKEVEELKSKNLSLESQIKTILDPLTLVQGNQNEDKHLVTDNPSKINPETVAEWKKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLVRENLRLKAEVDNRSPQKFGRFAVAALQSKVEQYERETSRLKKALERSDKYIEELESQVAQLKNSSEEKEAMNSICQTALPADGKGSKGSEEDVASKNQGDSARKQPSSSTSSSSHLAKPSSSRLCDTSSARQESTSKAELNCSKNKDLYQEQVEVMLDVTDTSMDTYLEREWGNKPSDCVPYKDEELYDLPAPCTPLSLSCLQLSTPENRESPVVQAGGSKKHSNHLRKLVFDDFCDSSNVSNKDSSEDDISRSENEKKSECFSSPKTAFWDCCSTSYAQNLDFESSEGNTIANSVGEISSKLSEKSGSCVSKRLNSIRSFEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSLDLDGLSKSSQGSEFLEEPDKLEEKTELNLSKGSLTNDQLENGSEWKPTSFFLLSPSDQEMNEDFSLHSSSCPVTNEIKPPSCLFQTEFSQGILLSSSHRLFEDQRFGSSLFKMSSEMHSLHNHLQSPWSTSFVPEKRNKNVNQSTKRKIQSSLSNASPSKATKS
What is the function of this protein?
E3 ubiquitin ligase essential for DNA replication origin activation during S phase.  Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase.
What are the official names of this protein?
ORC ubiquitin ligase 1, OBI1, RING finger protein 219.
What are the subcellular locations of this protein?
Chromosome. Note=Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase.
Protein: MYL9_MOUSE
Sequence: MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLEGMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD
What is the function of this protein?
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation.  Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).  In myoblasts, regulates PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (PubMed:29799007).
What are the official names of this protein?
Myosin regulatory light polypeptide 9, Myosin regulatory light chain 2, smooth muscle isoform, Myosin regulatory light chain 9.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts.
Protein: NUOD1_OPITP
Sequence: MATEFTVPDSAARIATAQQAGGGTPVRSGPPDEGGEFSGDRMSLSMGPSHPSTHGVLRIQMELEGEILTKADPIIGYLHRGDEKIAENMTYNQFVPYTDRLDYLAPLANNMAYVIAVEKLAGLTVPPRCQAIRVITAELARISSHLMGLGAFGLDVGAWTVLVLSLNQREFLYNLFEDLTGARFTTSYTRIGGVTRDVPPGWLENVGTFCDKFLPALEEILSLLTRNKIFLDRTVGVGVISKEDAIAYGITGPNARGSGIATDLRKDRPYSGYEQYEFDVPVGTKGDCYDRYLVRGEEMRQSVRIIRQVIKNFPGGDWYATEAKKVFLPPKGKVLSSMEELIQQFMLVTEGPQMPAGEVYFEAENPKGILGFYIVSKGGGVPYRLKIRSPSFCNLSLVPKLCQGVLISDVVAILGSLDFVMGECDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 1, NADH dehydrogenase I subunit D 1, NDH-1 subunit D 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: METK_METMA
Sequence: MARNIKVEELLQTPIEKQQIELVERKGIGHPDSISDGLAEAVSRALCREYITKCGAVLHHNTDETQIVAGRSSPKFGGGEVLQPIYMLLVGRATKEFEGAELATESVALKAARNYLRNTMVNMDLERDVIIDCKLGTGSSDLRDVFKRDRVPMANDTSFGVGHAPFSELENIVYNTERQLLTDLKSRMPAIGEDMKIMGLRDGDDISLTICSGMIGRYVDDLDSYINMTQEMKTYTEELAARYTERNVNVFVNTADNLKASCVFLTVTGTSAEMGDDGSVGRGNRCNGLITPNRPMSMEATSGKNPINHIGKIYNLLSTQMARDIVKQVPDVQDVYIRLLSQIGKPIDQPLVASAQIIPKEGTSFANVKSEAEVVIDDWLSNVTKITEMVIRGELNTF
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase 2 family.
Protein: E4PD_SALTI
Sequence: MTVRIAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRHEREQLFVGDDVIRILHERTLADLPWRELGVDVVLDCTGVYGNREHGEAHIAAGAKKVLFSHPGSNDLDATVVFGVNQNQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMNDQQVIDAYHSDLRRTRAASQSIIPVDTKLAAGITRIFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKASEVNQLLQKAAQGAFHGIVDYTESPLVSIDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMAAVGFRLDASASTKL
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HINT3_XENTR
Sequence: MSAEAGATVEQNHSYDMSCIFCRIANKQESGAELLHSDDDLVCFKDIRPAVTHHYLVVPKKHVGTCKTLTKDHVQLIKTMMEVGKSTLQKNNVTDLEDIRLGFHYPPFCSISHLHLHVLAPASQLGFLSRMIYRVNSYWFITADELIDQLQAS
What is the function of this protein?
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity).  Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (By similarity).
What are the official names of this protein?
Adenosine 5'-monophosphoramidase HINT3, Histidine triad nucleotide-binding protein 3, HINT-3.
What is the protein family that this protein belongs to?
Belongs to the HINT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NTF3_ERYCC
Sequence: IQSTSMDQGILTEDSMNSFIRTLIQAGIWKNKVPKQAARTKDGMQTTVKKTEAGADAMASKDTRLSFQPIVSVDAELLRQQRRFSSPRVLLSENTPLEPPPLYLTEEPTVLNRTSRRKREGKSHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRMGPS
What is the function of this protein?
Seems to promote the survival of visceral and proprioceptive sensory neurons.
What are the official names of this protein?
Neurotrophin-3, NT-3.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: OXLA_DABSI
Sequence: ADDKNPLEECFREDDHRIVREYIRKFGLKLNEFVQETENGWYFIKNIRKRVGEVKKDPGLLKYPVKPSEAGKSAGQLYQESLGKAVEELKRTNCSYILNKYDTYSTKEYLIKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDQLPTSMYRAIEESVRFKARVIKIQQNAEKVTVTYQTTQKNLLLETVDYVIVCTTSRAARRITFKPPLPPKKAHALRSVHYRSGTKIFLTCTKKFWEDDGIQGGKSTTDLPSRFIYYPNHNFTTGVGVIIAYGIGDDANFFQALNLNECADIVFNDLSSIHQLPKKDLQTFCYPSIIQKWSLDKYAMGAITTFTPYQFQHFSEALTAPVGRIFFAGEYTANAHGWIDSTIKSGLTAARDVNRASEL
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:19523971).  Is highly active on L-Leu followed by L-Phe and L-Ile, moderately active on L-Asp, L-Glu, and L-Lys, and not active on L-Pro, L-Asn, L-Gly, L-Ser and L-Cys (PubMed:19523971).  Exhibits diverse biological activities such as antibacterial activity (Minimal inhibitory concentrations (MIC) are 9. 0 ug/ml against S. aureus, 144. 0 ug/ml against P. aeruginosa and 288. 0 ug/ml against E. coli) and inhibition of ADP- and TMVA-induced platelet aggregation.  Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation.  These different effects are probably due to different experimental conditions.  Unlike other snake venom L-amino acid oxidases, does not induce hemorrhage.  This protein may also induce hemolysis, edema, apoptosis and have antiparasitic activities.
What are the official names of this protein?
L-amino-acid oxidase, DRS-LAAO, LAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ADK_YEAST
Sequence: MTAPLVVLGNPLLDFQADVTAEYLAKYSLKENDAILVDAKSGDAKMAIFDELLQMPETKLVAGGAAQNTARGAAYVLGAGQVVYFGSVGKDKFSERLLNENEKAGVKSMYQVQNDIGTGKCAALITGHNRSLVTDLGAANFFTPDHLDKHWDLVEAAKLFYIGGFHLTVSPDAIVKLGQHAKENSKPFVLNFSAPFIPHVFKDALARVLPYATVIIANESEAEAFCDAFQLDCANTDLEAIAQRIVKDSPVEKTVIFTHGVEPTVVVSSKGTSTYPVKPLDSSKIVDTNGAGDAFAGGFMAGLTKGEDLETSIDMGQWLAALSIQEVGPSYPSEKISYSK
What is the function of this protein?
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.  ADO1 does not play a major role in adenine utilization in yeast.  Its physiological role could primarily be to recycle adenosine produced by the methyl cycle.
What are the official names of this protein?
Adenosine kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: HAL5_VANPO
Sequence: MGTVEQKSTHTSPPTSPISRARSISGSIKSLFKPSSVQNSTPTVSPHESSPPLGNSDNLKKLVDTKRAELSSSRGAPPVNVNNVSNLSINTDVRPADDQPQVKSAKSPIIQTPKMAMNIVPQNIKSVLSSPRQSSSTNDRSSITSATSSVTSANDQKEKNYGSGNGSADDIPIAQLRLSEQDRAQDYTIDNALDTKDKSKPVKRNNSTSAFRGRKDKNFESSEYEIRSNSLSRIHSTPQNESPTVNNIHRGRPYSESISISSLKHIEQESKCILQVDNFKVFENGMHVHNLKIMPIVKSAQADAANDHDSNELNKQKSMFSLTSIFKSHKEDSGVDNSPLENLDNAVSLLPSIKNMAVYNRKRNISSSTAGTGGSDSDSIPDDLSERMVNPCAAIGAEELKLINTLSERINDAILCKSGKKSSHMLKEKDPDAMTFTQLYGKSMGVVLGHGAYGVVRLFSRNATERDPQYLQTYCNGQKMFFAVKELKPKSSEPKEKFSTRITSEFIIGHSLNHSEKKGGSKYSPNIIRVLDLLEISSGSFIEVLEFCPSGDLYNILTRKTKNGTALHPLEADCFMKQLLTGVQYMHSHGVAHCDLKPENILFHPNGLLKICDFGTSCVFQTAWEKNVHFQTGAVGSEPYVAPEEFIHDFNYDPRLVDCWSCGVVYCSMVLGHYLWKLAVKEKDPLYKAFYEEISSNKEFYVFEEMRHVNHEINRLRKISLYKIFQPNPDKRITIDQLLQSPWMKNTRCCIDYKTISS
What are the official names of this protein?
Probable serine/threonine-protein kinase HAL5-like.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NPR/HAL subfamily. HAL5 sub-subfamily.
Protein: TRPR_SALTI
Sequence: MTQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKTELGAGIATITRGSNSLKSAPVELRHWLEQILLKSA
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIHI_HAEIN
Sequence: MARKKKTRRITDIMPIRKADKKIDITKARSGKKLTCYELDAKAREDKKKRKHKGLASGSRHSAVEEKANKLQNEIKDPKIGSKKKIPLVVEFVNKPEKGQVIPVIKQVKKQDPMKELENLENNEILNELLDALDAGKTISKSDQQFVDECLDRISELMEELGIEDEDESEDDLYRTFERMDINQFR
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: CRCB_AROAE
Sequence: MAAAANLPAFLAVGAGAALGAWLRWALGLLLNPIFLTIPFGTLAANLLGGLLMGASLAWIHAVPAMSPVLKLLLTTGFLGGLTTFSTFSAEGLHLVQRGEWGWLALHAAVHVAGSLLMAWIGYAAFTAWRG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTH_BRUMB
Sequence: MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYKLTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNEWLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAEMLKKLLGKKD
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.