PharMolix/UniProtQA huggingface dataset:
Protein: SLRB_BITRH
Sequence: MGRFIFLSSGLLVVFLSLSGTGADQGCLPDWTLYEGYCYKVFKEKKTWADAEKFCKEQANGGHLVSLQSSEEVDFMVHQTFPILRYDFVWIGLSDFSRDCQWKWSDYSKLFYKAWNNEPNCFVCKTTDNQWLRRDCNRQQYFVCKSRVPR
What is the function of this protein?
Antagonist of the alpha-2 subunit of the integrin alpha-2/beta-1 (ITGA2/ITGB1) on human platelets and endothelial cells.  This protein inhibits collagen-stimulated activation of human platelets in a dose-dependent manner.  In addition, it antagonizes the binding of monoclonal antibodies against the alpha-2 subunit of integrin alpha-2/beta-1 to platelets and it coimmunoprecipitates with this integrin.
What are the official names of this protein?
Snaclec rhinocetin subunit beta, C-type lectin like protein 2.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y324_LIGS1
Sequence: MKITWHGHAFIEIQVAGKQILIDPFITGNPFTKTKPEDLNPDYILLTHSHRDHVGDTEELAKKSGATIVTEMDMVNDYAQKGFKVEGPNYGGTVHFDWGDVKIIPAWHTTANVPLGMATGLALTIEGKLIYIAGDTGLFSDMKLVGRKQQIDLAFLPIGDYYTMGPDDAAYAASLIEAKKVIPDHFNTFPPIKQDVNDFWKDVPENMKFTAEIDKPFEL
What are the official names of this protein?
UPF0173 metal-dependent hydrolase LSL_0324.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: FIEF_SALCH
Sequence: MNQTYGRLVSRASIAATAMASALLLIKIFAWWYTGSVSILAALVDSLVDIAASLTNLLVVRYSLQPADDEHTFGHGKAESLAALAQSMFISGSALFLFLTSIQNLIKPTPMNDPGVGIGVTVIALICTIILVTFQRWVVRKTQSQAVRADMLHYQSDVMMNGAILIALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDAERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDNLPLVQAHFVADQVEQAILQRFPGSDVIIHQDPCSVVPREGRKFELV
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRMB_CLOBJ
Sequence: MRLRKKWWARPEIEASDKFAEEPKELRGKWNKEFNNNNDIHLELGCGRGGFISQLVEKNKDINYVGIDLKDEVIVYAIRKVKEKEEEVKREFKNIKFVTMNIMGIAEVFDKNEISKIYINFCNPWPKERHNKRRLTHTKLLTEYKKFLKPNTEIWFKTDDKELFEDSQEYFKESGFNIEYITYDLHNSDFKENIKTEYETKFETMGMKIMFLKARLL
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: ACCC_POPEU
Sequence: ILVANRGEIAVRLLEEAPSPALTPELRITAYLPSGGPFVR
What is the function of this protein?
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
What are the official names of this protein?
Biotin carboxylase, Acetyl-coenzyme A carboxylase biotin carboxylase subunit A.
Protein: POLG_PVYYO
Sequence: VALDDEFEFDSYEVHHQANDTIDAGGNNKKDAKPEQSSIQSNLSKGKDKDVNVGTSGTHTVPRIKAITSKMRMPRSKGVAALNLEHLLEYAPQQIDISNTRATQSQFDTWYEAVRMAYDIGQTEMPTVMNGLMVWCIENGTSPNINGVWVMMDGNEQVEYPLKPIVENAKPTLRQIMAHFSDVAEAYIEMRNKKEPYMPRYGLIRNLRDISLARYAFDFYEVTSRTPVRAREAHIQMKAAALKSAQPRLFGLDGGISTQEENTERHTTEDVSPSMHTLLGGKNM
What is the function of this protein?
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae genome polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein]: Virion.
Protein: YOCA_BACSU
Sequence: MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDTKTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRNEITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEELAKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLETMESKAHE
What are the official names of this protein?
Uncharacterized membrane protein YocA.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: XY30A_MYCTT
Sequence: MYSLLIALLCAGTAVDAQALQQRQAGTTLTVDLSTTYQRIDGFGTSEAFQRAVQMSRLPEEGQRRALDVLFSTTNGAGLSILRNGIGSSPDMSSDHMVSIAPKSPGSPNNPLIYSWDGSDNKQLWVSQEAVHTYGVKTIYADAWSAPGYMKTNGNDANGGTLCGLSGAQCASGDWRQAYADYLTKYVEFYQESNVTVTHLGFINEPELTTSYASMRFSASQAAEFIRILYPTIQKSNLTYKPTIACCDAEGWNSQAGMLGALSSVNSMFGLVTAHAYTSQPGFSMNTPHPVWMTEAADLQGAWTSAWYSYGGAGEGWTWANNVYNAIVNGNASAYLYWIGAQTGNTNSHMVHIDANAGTVEPSKRLWALGQWSRFVRPGARRVAVSGASGSLRTAAFRNEDGSVAVVVINSGGDAAVNVRLASSSSADQQPASAKAWATDNSRAIEEIQASFADGVATVNVPSRSMTTVVLYPAADA
What is the function of this protein?
Xylanase exhibiting endo- and exo-xylanase activity (PubMed:31110561).  Shows the highest activity toward beechwood glucuronoxylan, which consists of a beta-1,4-linked xylose backbone decorated with the methylated form of D-glucuronic acid (MeGlcA) attached directly to the main chain at xylose C2 (PubMed:31110561).  Acts also against wheat arabinoxylan, a xylan without MeGlcA substituents along the main chain, but the xylanase activity is about two orders of magnitude lower than that achieved in the case of beechwood xylan (PubMed:31110561).  Shows no activity against carob galactomannan, konjac glucomannan, or barley beta-glucan (PubMed:31110561).  The recombinant xylanase also exhibits an exo-activity by releasing processively disaccharide units from the non-reducing end of linear and decorated xylooligosaccharides (XOS) (PubMed:31110561).
What are the official names of this protein?
GH30 family xylanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTHD4_HUMAN
Sequence: MCFLRRPGAPASWIWWRMLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTGDNILLQAEGILQTHRAVLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV
What is the function of this protein?
Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells.
What are the official names of this protein?
Patched domain-containing protein 4, p53-regulated patched protein.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DPS_KLEP3
Sequence: MSTAKLVKSKASNLVYTRNDVADSEKKATIELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALTEHLDTMAERAVQLGGVALGTTQVINSKTPLQSYPLDIHHVQDHLKALADRYAVVANDVRKAIDEAKDEDTADIFTAASRDLDKFLWFIEANIE
What is the function of this protein?
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages.  It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_STRZT
Sequence: MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQFLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVHLLNFANLAAYQFFDQPQKVALEIREGLREEQMQNVRVADGQESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQVNVVNRVLTMKLTDFYRYLSSNHYEVH
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: FABA_XYLF2
Sequence: MSRQHAYSREELLATARGELFSHSNARLPNDPMLMFDRITEIYADGGSHGKGIVNAELDIRPDLWFFGCHFLGDPVMPGCLGLDAMWQLTGFFLTWSGATPGYGRALGCGEVKFTGQVLPNAKLVRYEVEMTKIINRTLVIGQANARMLVDNREIYFAKDLRVGMFNNTESF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRDB_LISMF
Sequence: MNRLAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNELGAIMAKAVTPEPRLGNPTPRVAETASGMLNAIGLQNPGLEHVLAHELPFLEQFETPIIANVAGATEDDYVQVCARIGESKAVKAIELNISCPNVKHGGIAFGTDPDVAHRLTKAVKNVATVPVYVKLSPNVADIVSIAQAIEAAGADGLTMINTLLGMRIDLKTRKPIIANGTGGLSGPAIKPVAIRMIHQVREVSNIPIIGMGGVQTVDDVLEFLIAGADAVAVGTMNFTDPFICPKLISELPKRMDELGISSLQELKKERANQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCRS_MOUSE
Sequence: MASAFSKLLTGRNASLLFTTLGTSALTTGYLLNRQKVSADAREQHKLFPPSADYPDLRKHNNCMAECLTPTIYAKLRNKMTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITHGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGRK
What is the function of this protein?
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e. g.  creatine phosphate).  Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).
What are the official names of this protein?
Creatine kinase S-type, mitochondrial, Basic-type mitochondrial creatine kinase, Mib-CK, Sarcomeric mitochondrial creatine kinase, S-MtCK.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: PTSO_ECOL6
Sequence: MTVKQTVEITNKLGMHARPAMKLFELMQGFDAEVLLRNDEGTEAEANSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIALFNSGFDED
What is the function of this protein?
Component of the phosphoenolpyruvate-dependent nitrogen-metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism.  The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein NPr by enzyme I-Ntr.  Phospho-NPr then transfers it to EIIA-Ntr.  Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins.
What are the official names of this protein?
Phosphocarrier protein NPr, Nitrogen-related HPr.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP1_CYAPA
Sequence: MTILIQQYTNDENKKLELNNISKLLQNRIILFSQTVDDEICNSIVGQLLYLENEDSTKDIRLFINSPGGSVTAGLSVYDTIQNLSVDVSTICFGLAASMGAVLLAAGVENKRFAFASSRIMIHQPLSKVEAPWSHLDIQIRNGAYFKNLLNNILSFHTKQELKQIETDTERDFFLSATEAKQYGIIDHIFINNN
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins (By similarity).
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: ACPS_OCEIH
Sequence: MICGVGIDIIELNRMEALIERNERFIERILTENEQRKFQRLSANRKVEYIAGRFAAKEAFAKAVGTGIGKVSFKDIEIINNDYGAPNMKVKGYNDNVIHLSISHSKTYAVANVVLETRE
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_HERAR
Sequence: MDKKQSRLRRGRQTRAKIAELKVIRLAVHRTNLHIYASIIGPDAKILASASTAEAEVRKELAGQSGAGGNVAAAALVGKRVAEKALKAGIAEVAFDRSGFRYHGRVKAVAEAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: VPS53_CHICK
Sequence: MEEDELELAAGLEAALELAPAVQAAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRKLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVVNVLEHFNKYMGIPQIRQLSERVKAAQNELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANVLDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPQEWCMTERIAVEFCHVTRTELAKIMRTRAKEIEVKLLLFAIQRTTNFEGLLAKRFSGCTLADGTVKKPEAPPPSTNPFLEDETGTETDEIVIEKSDADKPKKPKVPDNPFHGIVSKCFEPHLYVYIESQDKNLSELIDRFVADFKAQGPPKPNVDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALTTIFQKYLREYAWKILSGNLPKTTSSSGGLTITSLLKEKEGSEVAKFTLEELCLICSILSTAEYCLATTQQLEEKLKEKVDASLVERINLTGETDTFSIVISNSIQLLVQDLDAACDPALTAMSKMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCIKFANSFIPKFINHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPSIGSQVVRKAPASYTRIVVKGMTRAEMILKVVMAPHEPPVVFVDNYIKLLADCSTDTFQKILDMKGLKRSEQSSMLELFRQRLPAPPSGVENSGSLSLSAPTPEQESSRIRKLEKLIKKRL
What is the function of this protein?
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).  Acts as component of the EARP complex that is involved in endocytic recycling.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 53 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS53 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Protein: HEM3_ALKEH
Sequence: MPQDKLRIATRRSPLAMWQAEHVAAELRRHHPGLEVELVPMVTRGDRILDQALSRIGGKGLFIKELEQGMEEGRADLAVHSMKDVPWRMPDGFALPVILERHEPTDAFVSNHYRRLDDLPEGGHLGTASLRRQCQAKARRPDLRVSTLRGNVNTRLAKLDAGEFDAIILAASGLSRLGFDERIARRLPPEESLPAVGQGALGIECLAEDRRVQELVAPLDHGPTHTLLKAERAMNARLQGSCQVPIAGYACYQGEEIWLRGLVGSPDGQEIVRGEVRGPIAQAAELGDRLGGELLERGAARILADLAD
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PLPK2_ARATH
Sequence: MTLKKSFSASLLSPFLIICLIALLSVPVSVGARRLLEEPKPEIPTFPELPKPEMPKLPEFPKLELPKLPEIPKPEMPKLPEIQKPELPTFPELPKMPEFPKFDFPKLPELPKPEETKVPAFTMPKFPGSP
What are the official names of this protein?
Protein PELPK2, Protein Pro-Glu-Leu|Ile|Val-Pro-Lys 2.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: FMTA_STAAC
Sequence: MKFNKVKLVIHACVLLFIIISIALIFHRLQTKTHSIDPIHKETKLSDNEKYLVDRNKEKVAPSKLKEVYNSKDPKYKKIDKYLQSSLFNGSVAIYENGKLKMSKGYGYQDFEKGIKNTPNTMFLIGSAQKFSTGLLLKQLEEEHKININDPVSKYLPWFKTSKPIPLKDLMLHQSGLYKYKSSKDYKNLDQAVKAIQKRGIDPKKYKKHMYNDGNYLVLAKVIEEVTGKSYAENYYTKIGDPLKLQHTAFYDEQPFKKYLAKGYAYNSTGLSFLRPNILDQYYGAGNLYMTPTDMGKLITQIQQYKLFSPKITNPLLHEFGTKKYPDEYRYGFYAKPTLNRLNGGFFGQVFTVYYNDKYVVVLALNVKGNNEVRIKHIYNDILKQNKPYNTKGVIVQ
What is the function of this protein?
Catalyzes the liberation of D-alanyl moieties present on wall teichoic acid (WTA) and lipoteichoic acid (LTA) (By similarity).  Affects the methicillin resistance level and autolysis in the presence of Triton X-100 as well as the cell wall structure (PubMed:9371333, PubMed:10471551).
What are the official names of this protein?
Teichoic acid D-alanine hydrolase, Teichoic acid D-alanine esterase.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RRP42_THEGJ
Sequence: MSDVEIMAGIMRDRILNLLKEGKRIDGRSFEEYRDIEIKTGFIEKAEGSAWVRLGGTRVLVGIKVDVGEPFPDLPDRGVMTTNVELVPLASPTFEPGPPDERAIELARVIDRGIRESQAVELEKLVIVPGKLVRVVFIDVHVLDHDGNLFDATGLAAMAALMTTKIPKVEYNEETGEIIKLDEYEPLPVKHVPIPVTFAKIGSSIIVDPNLDEETVMDSRLTITTDETGHISAVQKGEGGSFKLEEVMYAIDTALKKADELRKILLEAVGSAS
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Contributes to the structuring of the Rrp41 active site.
What are the official names of this protein?
Exosome complex component Rrp42.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp42 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VTF3L_VACCA
Sequence: MDNLFTFLHEIEDRYARTIFNFHLISCDEIGDIYGLMKERISSEDMFDNIVYNKDIHHAIKKLVYCDIQLTKHIINQNTYPVFNDSSQVKCCHYFDINSDNSNISSRTVEIFEREKSSLVSYIKTTNKKRKVNYGEIKKTVHGGTNANYFSGKKSDEYLSTTVRSNINQPWIKTISKRMRVDIINHSIVTRGKSSILQTIEIIFTNRTCVKIFKDSTMHIILSKDKDEKGCIHMIDKLFYVYYNLFLLFEDIIQNEYFKEVANVVNHVLTATALDEKLFLIKKMAEHDVYGVSNFKIGMFNLTFIKSLDHTVFPSLLDEDSKIKFFKGKKLNIVALRSLEDCINYVTKSENMIEMMKERSTILNSIDIETESVDRLKELLLK
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from intermediate gene promoters.
What are the official names of this protein?
Intermediate transcription factor 3 large subunit, VITF-3 45 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviruses A23 family.
Protein: PPIA_BOVIN
Sequence: MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFDDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQI
What is the function of this protein?
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity).  Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity).  Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity).  In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity).  Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity).  Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity).  Plays an important role in platelet activation and aggregation (By similarity).  Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).  Binds heparan sulfate glycosaminoglycans (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Protein: RL13_SALPB
Sequence: MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMFRKLKVYAGNEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: FDHE_PSEPK
Sequence: MITDEKKDERLSIILEPGQIEASAVTPPFLHLPAANLFELRAARLEQLAEGNALGDYLRLIARLCRIQQQLVDNPPGGMPVAEARQRLCMDHGLPPLAADSLVREGPWLVWLQALLEHLSGETRGPMGEALQVLRGSDDNQRKGWGIALLAGQYDGVPAALVPFLGAALQAAWSSWLLALPAHQLKPAGSLAQCPACGSPAMAGVVRNRGKHNGLRYLACSLCACEWHVVRVKCVYCESSKDLRYTSLEDDRHAPGKAPLRAECCPGCDSYLKQNYLENDAAAEPLADDLASLALDIRLDGEGFHRLAPNLMLAPGGG
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE homolog.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.