PharMolix/UniProtQA huggingface dataset:
Protein: FABP1_AMBME
Sequence: SFAGKYELQSQENFEAFMKAIGLPDELIQKGKDIKSVSEIQQNGKSFKVTVTTGSKVLENEFTLGEEAELETLTGEKVKSIVKQEGDNKLVVNLKGITSVTELSGDTLINTLQKGDDTYKRISKRI
What is the function of this protein?
Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm.  May be involved in intracellular lipid transport (By similarity).  The specificity of axolotl L-FABP differs from that of LB-FABP.
What are the official names of this protein?
Fatty acid-binding protein 1, liver, Liver-type fatty acid-binding protein, L-FABP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_SHIDS
Sequence: MYQDKILVRQLGLQPYEPISQAMHEFTDTRDDSTLDEIWLVEHYPVFTQGQAGKAEHILMPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVNTLAELGIEAHPRADAPGVYVGEKKICSLGLRIRRGCSFHGLALNVNMDLSPFLRINPCGYAGMEMAKISQWKPEATTNNIAPRLLENILALLNNPDFEYITA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRB_CAEEL
Sequence: MTTKKFRMEDVGLSKLKVEKNPKDVKQTEWKSVLPNEVYRVARESGTETPHTGGFNDHFEKGRYVCLCCGSELFNSDAKFWAGCGWPAFSESVGQDANIVRIVDRSHGMHRTEVRCKTCDAHLGHVFNDGPKETTGERYCINSVCMAFEKKD
What is the function of this protein?
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine (By similarity).  While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue (By similarity).
What are the official names of this protein?
Probable methionine-R-sulfoxide reductase B.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: RUVA_RHIEC
Sequence: MIGKLKGTIDEIGEDYVLVDVQGVCYVAYCSARTLSKLGSAGEACVLFIETYVREDQLKLFGFMTALEREWFNLLQSVQGVGAKVALAVLSTLTPGELANAIALQDRAAVSRAPGVGPKVAMRLVTELKNRAPAYAGEAINIALKRELGEGVAAAPVADAVSALTNLGYSRDQAANAVAAAMKTAGEGADSAKLIRLGLKELAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: CLP1_NEOFI
Sequence: MSLPGLELSQTSSEREFVPAPPTQITLSKGSEWRFEVAFGTAIRVKLLAGTAELFGTELAASQTYTFSGTKAAIYTWHGCTLEVSAGDTISTIDGLGPAGLNGEGARGYGAGGCQSEYTAEETPMVEYANVHFALEAMRQEAKATGKDGPRVLILGPENAGKTSVAKILTAYATKVGRQPIVVNLDPAEGMLSVPGTLTATAFRTMMNVEEGWGSSPMSGPSAVPVKLPLVYFYPLQNPLEAEGAVYRPIVSRLALSVTGRMAEDEDTRETGIIVDTPGILSAGKPGSLEIINHIVTEFAITTILVIGSERLYSTMMKNYDNKPTSSASAAASDERITVVKLSKSGGCVDRDAAFMKSVRESQIRTYFFGNPIPSTASAALSMSASSTTNVTLSPHAQQLDYDSLAVYNYTIASSDEDEDEYDPSQFGTSDTFLPKGSNDAEGPEAKHAEETSFASSVPGLGGSSGEDAASGSSAVPLKKVPPPAPNTLANSLLAVTHAAPNASPAEIRDASIMGFLYVADVDSEKGKIRVLAPIGGRVPPRAIVWGKKWPGEVVGLVG
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
mRNA cleavage and polyadenylation factor clp1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DCAM_SOLCI
Sequence: MDLPVSAIGFEGFEKRLEISFVEPGLFADPNGKGLRSLTKAQLDEILGPAECTIVDNLSNDYVDSYVLSESSLFVYSYKIIIKTCGTTKLLLAIPPILRLAETLSLKVQDVRYTRGSFIFPGAQSFPHRHFSEEVAVLDGYFGKLAAGSKAVIMGNPDKTQKWHVYSASAGTVQCNDPVYTLEMCMAGLDREKASVFYKTEESSAAHMTVRSGIRKILPKFEICDFEFEPCGYSMNSIEGAAVSTIHITPEDGFSYASFESVGYDPKTTELGPLVERVLACFEPAEFSIALHADVATKLLERVCSVDVKGYSLAEWSPEEFGKGGSIVYQKFTRTPYCESPKSVLKGCWKEEEKEEKE
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: RR12_CHAGL
Sequence: MPTIQQLIRNRREPIENRTKSPALRSCPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDSVGVKDRHQGRSKYGAKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EFEU_SHISS
Sequence: MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKEQELFEGIVAVIAVVILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNHHGWALVMMVFFAVAREGLESVFFLLAAFQQDVGIWPPLGAMLGLATAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFGYQEAPSVSEVAVWFIYLIPALVAFALPPRAGATASRSA
What is the function of this protein?
Uptake of Fe(2+) ions across the membrane.
What are the official names of this protein?
Ferrous iron permease EfeU, Fe(2+) ion permease EfeU, Ferrous iron uptake protein.
What is the protein family that this protein belongs to?
Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AN13B_HUMAN
Sequence: MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPMELTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISPALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTHPMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQEQEERRRRARQEEEELERILRLSLTEQ
What is the function of this protein?
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin.  Does not bind 'Lys-48'-linked ubiquitin.  Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 13B.
What are the subcellular locations of this protein?
Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
Protein: ARY1_MESAU
Sequence: MDIEAYFERIGYNNPVYTLDLATLTEVLQHQMRTIPFENLNMHCGEAMDLGLEATFDQIVRKKRGGWCLQVNHLLYWALTQMGFETTMLGGYVYIVPVSKYSSEMIHLLVQVTISDRNYIVDAAYGGSYQMWEPVELASGKDQPQVPAIFRLTEENETWYLDQIRREQHVPNQEFVNSDLLEKNTYRKIYSFTLQPRTIEDFEYANTYLQISPVSVFVNTSFCSLQTSEGVCCLIGSTIARRKFSYKENVDLVEFKNVSEEEIEDVLKTAFGVSLERKFVPKNGNLSFSI
What is the function of this protein?
Participates in the detoxification of a plethora of hydrazine and arylamine drugs.
What are the official names of this protein?
Arylamine N-acetyltransferase 1, Arylamide acetylase 1, Monomorphic arylamine N-acetyltransferase, MNAT, N-acetyltransferase type 1, NAT-1.
What is the protein family that this protein belongs to?
Belongs to the arylamine N-acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF5A3_SOLTU
Sequence: MSDEEHHFESKADAGASKTYPQQAGTIRKNGYIVIKGRPCKVVEVSTSKTGKHGHAKCHFVAIDIFNGKKLEDIVPSSHNCDVPHVNRTDYQLIDISEDGFVSLLTESGNTKDDLRLPTDESLLKQVKDGFQEGKDLVVSVMSAMGEEQINAIKDIGTKN
What is the function of this protein?
The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Eukaryotic translation initiation factor 5A-3, eIF-5A-3, eIF-4D.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
Protein: HYAL2_BITAR
Sequence: MYHLWIKCLAAWIFLKRCNGVHAMPAKAPMYPNEPFIVLWNAPTTQCPLRYKVDLDLKTFHIVANANDSLSGSVVAIFYPNHLGVYPHIDERGHFFHGIIPQNESLTKHLNKSKSDINRMIPLKTFHGLGVIDWENWRPQWDRNWGSKNVYRNRSIQFAKKLHPELSEDKIKRLAKKEYEKAAKSFMRDTLLLAEEMRPNGYWGYYLYPDCQNYDYKTKGDQYTGKCPDIEMSRNDQLLWLWRDSTALFPNVYLEIILRSSDNALKFVHHRLKESMRIASMAREDYALPVFVYARPFYAYTFEPLTQEDLVTTVGETAAMGAAGIVFWGSMQYASTVDSCQKVKTYMNGPLGRYIVNVTTAAKICSHALCRKNGRCVRKHSDSNAFLHLFPESFRIMVHANATEKKAIVKGKLELKDLIYLRKNFMCQCYQGWKGLYCEEYSIKDIRKI
What is the function of this protein?
Snake venom endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments.  In venom, it is not toxic by itself, but increases the diffusion of other venom proteins by degrading the extracellular matrix.  In addition, it displays antiedematogenic activity (By similarity).
What are the official names of this protein?
Hyaluronidase-2, Hy-2, Hyaluronoglucosaminidase-2, Venom spreading factor.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Secreted.
Protein: COAE_PHOPR
Sequence: MTMVIGLTGGIGSGKTTVANLFGDYGIDIIDADIIAREVVEPNTTGLNAIVDKLGADILLTDGTLDRSKLRNAIFNQQQLKDWLNGLLHPLIREKMLSNISKATSPYCLLVVPLMVENNLQTMTHRLLVVDVDESVQIDRTQARDNVAPEHVKKILMAQASRQNRNAAADDIISNNGNSAELKNKVAELHQKYIKMSHLY
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_RHILW
Sequence: MPVADTSQLTSGVAERYASSLFDLALEQGAVDSVTADLDRFQAMLDESADLKRFVASPVFSAEDQLKAIVAISEKAGISGFFANFLKVVARNRRLFALPGMIKAFRIIAANHRGEISAEVTSAHALSQAQETELKVALKSVTGKDVTIAVTVDPSILGGLIVKVGSRQIDTSLRTKLSTLKLALKEVG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ERPA_DECAR
Sequence: MNAVNEMAVPFVFTDNAAGKVKELIEEEGNPGLKLRVFVTGGGCSGFQYGFTFDEEVNEDDTTMEKNGVTLLIDPMSYQYLVGAEIDYTEGLEGSQFVIRNPNATSTCGCGSSFSA
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: Y769_STAAM
Sequence: MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
What are the official names of this protein?
Epimerase family protein SAV0769.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
Protein: AIM26_YEAST
Sequence: MQTMGGEHLLLSQLKGSFFLLLLAYFFRGRSPYYARCYRRLAVTPGAITIAIAIATDSIPALAKSKVLVSVCSHTDPCTASCNLIPFPRPFSNSLTRFLFCLGSARFCISFPCFGLSI
What is the function of this protein?
Involved in selective mitochondria autophagy (mitophagy).
What are the official names of this protein?
Altered inheritance of mitochondria protein 26, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: ACPS_PAEAT
Sequence: MIVGIGVDVVDIERFGRQLERTPGLRDRLFVPAERELNTRSLAARFAAKEAVAKVLGAPAGMNWQDCWIGLDENGPTVQVKGTVLAVAEAKGVKRWHLSMSHDGGIATATVLAEG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACON_CAEEL
Sequence: MNSLLRLSHLAGPAHYRALHSSSSIWSKVAISKFEPKSYLPYEKLSQTVKIVKDRLKRPLTLSEKILYGHLDQPKTQDIERGVSYLRLRPDRVAMQDATAQMAMLQFISSGLPKTAVPSTIHCDHLIEAQKGGAQDLARAKDLNKEVFNFLATAGSKYGVGFWKPGSGIIHQIILENYAFPGLLLIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGIKLTGKLNGWTSAKDVILKVADILTVKGGTGAIVEYFGPGVDSISATGMGTICNMGAEIGATTSVFPYNESMYKYLEATGRKEIAEEARKYKDLLTADDGANYDQIIEINLDTLTPHVNGPFTPDLASSIDKLGENAKKNGWPLDVKVSLIGSCTNSSYEDMTRAASIAKQALDKGLKAKTIFTITPGSEQVRATIERDGLSKIFADFGGMVLANACGPCIGQWDRQDVKKGEKNTIVTSYNRNFTGRNDANPATHGFVTSPDITTAMAISGRLDFNPLTDELTAADGSKFKLQAPTGLDLPPKGYDPGEDTFQAPSGSGQVDVSPSSDRLQLLSPFDKWDGKDLEDMKILIKVTGKCTTDHISAAGPWLKYRGHLDNISNNLFLTAINADNGEMNKVKNQVTGEYGAVPATARKYKADGVRWVAIGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANPADYDKIDPSDNVSIVGLSSFAPGKPLTAIFKKTNGSKVEVTLNHTFNEQQIEWFKAGSALNRMKEVFAKSK
What is the function of this protein?
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
What are the official names of this protein?
Probable aconitate hydratase, mitochondrial, Aconitase, Citrate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RPIA_PROM3
Sequence: MADLQTQMKQAVAAAAVEQIKDGMVLGLGSGSTAALMIQALGAKLASGELREIVGVTTSFQGEVMAAELGIPLRNLTAVDRIDLAIDGADEVDPSFQLIKGGGACHVQEKLVASRADRFVVVVDSTKIVDRLNLGFLLPVEVLPGAWRQVQGRLAELGGIADLRMAQCKAGPVVTDQGNLVLDVSMAGGIGDPEDLECRINNLPGVLENGLFVNLTDEVLVGQISDGVAGVRRLQRRE
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: PRISS_STRE2
Sequence: MAHETTSGRRLPDPTSPSDPTRRTAAIRIPFPARLNPHAERARQHTLQWVQETGLLTGDEATAEYDTLRLERLMAYFYPDASAGDLELAADFNAWFFIFDDQFDGGLGTRPHEIRGVVDALVGTMTTDGAPRPADVRDTPLVRAFRDIWLRSTAGAPYAWRLRFRDHWQAYLAAHVGEAHHRNADRLPSLEQFLEVRRHSIGVQPCLDFTERCGGYALPDELYRSFPLREMREITGDVVIFVNDIVSLVKELAAGDINNSVVIEREHKGCTLEESVEHITALANARTARFARLAASLPGTLADLGVPAPSREHVSHYVDGMRHVMAGNLSWSLATSRYDETGIAAVSGGRRRPWDGLTTATGTASPRHPRRA
What is the function of this protein?
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield a new 5-8 bicyclic (pristinane) sesquiterpenol (+)-(2S,3R,9R)-pristinol via a 1,11-cyclization, which requires the abstraction of the pyrophosphate from FPP to yield the humulyl cation.  The only accepted substrate is farnesyl diphosphate (FPP).
What are the official names of this protein?
Pristinol synthase, Terpene synthase, Type I terpene cyclase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: CALR_MACFA
Sequence: MLLSVPLLLGLLGLAAAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL
What is the function of this protein?
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle.  This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER.  Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity).  Involved in maternal gene expression regulation.  May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).  Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).
What are the official names of this protein?
Calreticulin.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Cytolytic granule. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity).
Protein: MKC1_CANAX
Sequence: MDQQEAPIYYGRSVNKVYNQEFIIDSRFKIVKELGHGAYGIVCSAKYDNGSKKVPDSNNGNASSSANASFVAIKKITNIFSKNILCKRALRELKLLQFFRGHKNITCLYDLDIIPNPMTGEFNEIYLYEELMECDMHQIIRSGQPLSDQHYQSFIYQVLCGLNFIHSADVLHRDLKPGNLLVNADCELKICDFGLARGFSENPDENAGFMTEYVATRWYRAPEIMLSFTNYTKAIDIWSVGCILAELLGGKPLFRGKDYVDQLNQILMILGTPPESTLQRIGSHRAQNYVRSLPITRKASYEELFPDANPLALDLLERMLTLDPRERITVRDALNHKYLELWHDPKEEIECQVKFDFKSFETVDGLDEMKQLIMDEVQKFREFVRKPIEEQQRIQMQLHMQKREEQRQEEEEKELLEQQRQFPAQESMDISQTPYNNLETNIGTPQVEDDYPRPQELDEFTFSNLESSSSMNLFQDMAKPSGEEYIKLEEELGFGLDWCYV
What are the official names of this protein?
Mitogen-activated protein kinase MKC1, MAP kinase MKC1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: SECB_PSEP1
Sequence: MTDQQTNGAAAEDNSPQFSLQRIYVRDLSFEAPKSPQIFRQTWEPSVALDLNTKQKSLEGDFHEVVLTLSVTVKNGDEVAFIAEVQQAGIFLIANLDAPSMSHTLGAFCPNILFPYAREALDSLVTRGSFPALMLSPVNFDALYAQEMQRMQEAGEAPTVQ
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZC21C_PONAB
Sequence: MAGLQRLASHLPVGVMLPHNTTEAPGPHSAKQDSYEQGDSSQQSLKGHLRNNFQKQLLSNKELTLDKVYTHPKWNTHTKARSYSYPHCTGISQQDPESDSQGQGKGLFYSSGPQSWYPKANNQDFIPFTKKRVGVDRAYPLKPVVHRKSCSTGEAGTDGYHNVYPRPPEPREFSSRNFGVRNQGNFSVVGTVLAAMQAEKAVANFDRTEWVQIRRLEAAGESLEEEIRRKQILLRGKLKKTEEELRRIQMQKEQAKENENRELQKIILPRSRVKGNNSNTMYKPIFSPEFEFEEEFSRDRREDETWGRSQQNSSPFQLSDYRIQRLKRERLVASNNKIQDRVSELSVEKFSLPSETPGGALQGSARNSSLSMAPDSSGSSGSIEEPQLG
What are the official names of this protein?
Zinc finger C2HC domain-containing protein 1C homolog.
What is the protein family that this protein belongs to?
Belongs to the ZC2HC1 family.
Protein: TX264_MOUSE
Sequence: MPDLLLLGLIGALTLLLLLTLLAFAGYSGLLTGVTVSAGSPPIRNITVAYKFHVGSYGDTGHLFTESCSISPKLRSIAVYYDNPHTVPPEKCRCAVGSILSEGEESPSPELIHLYQKFGFKIFSFPAPSHVVIATFPYTTPISIWLAARRVHPALDTYIKERKLCAHPRLEIYHQDKIHFMCPLARQGDFYVPEVKETERKCRELAEATDTQTDGTGADTSDASSVSLDVRPGSRETSATTLSPGAGNRGWDDGDNRSEHSYSESGASGSSFEELDLEGEGPLGEPRLNPEAKLLGPPRELSTPERGEE
What is the function of this protein?
Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.  The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins.  Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure.  Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN.
What are the official names of this protein?
Testis-expressed protein 264 homolog.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cytoplasmic vesicle, autophagosome. Cytoplasm, cytosol. Nucleus. Chromosome. Note=Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif. Also found in the cytosol, nucleus and chromatin. In response to formation of covalent DNA-protein cross-links (DPCs), localizes to the nuclear periphery, and associates with DNA replication forks.
Protein: FLGE_HELPY
Sequence: MLRSLWSGVNGMQAHQIALDIESNNIANVNTTGFKYSRASFVDMLSQVKLIATAPYKNGLAGQNDFSVGLGVGVDATTKIFSQGNIQNTDVKTDLAIQGDGFFIISPDRGITRNFTRDGEFLFDSQGSLVTTGGLVVQGWVRNGSDTGNKGSDTDALKVDNTGPLENIRIDPGMVMPARASNRISMRANLNAGRHADQTAAIFALDSSAKTPSDGINPVYDSGTNLAQVAEDMGSLCNEDGDALLLNENQGIWVSYKSAKMVKDILPSAENSTLELNGVKISFTNDSAVSRTSSLVAAKNAINAVKSQTGIEAYLDGKQLRLENTNELDGDEKLKNIVVTQAGTGAFANFLDGDKDVTAFKYSYTHSISPNADIGQFRTTEDLRALIQHDANIVKDPSLADNYQDSAASIGVSVNQYGMFEINNKDNKNVIKENLNIFVSGYSSDSVTNNVLFKNAMKGLNTASLIEGGASASSSKFTHATHATSIDVIDSLGTKHAMRIEFYRSGGAEWNFRVIVPEPGELVGGSAARPNVFEGGRLHFNNDGSLAGMNPPLLQFDPKNGADAPQRINLAFGSSGSFDGLTSVDKISETYAIEQNGYQAGDLMDVRFDSDGVLLGAFSNGRTLALAQVALANFANDAGLQALGGNVFSQTGNSGQALIGAANTGRRGSISGSKLESSNVDLSRSLTNLIVVQRGFQANSKAVTTSDQILNTLLNLKQ
What is the function of this protein?
A flexible structure which links the flagellar filament to the drive apparatus in the basal body.  Absence of the gene leads to absence of the hook protein, lack of the flagellar filament and thus loss of mobility.  Approximately wild-type levels of the flagellar subunits are still produced and accumulate mostly in the cytosol.
What are the official names of this protein?
Flagellar hook protein FlgE.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: URE2_STAAW
Sequence: MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKHLDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDEYAGVFGDNGAENVNKKGGKRS
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.