PharMolix/UniProtQA huggingface dataset:
Protein: RBS1_ORYSJ
Sequence: MAPSVMASSATTVAPFQGLKSTAGMPVARRSGNSSFGNVSNGGRIRCMQVWPIEGIKKFETLSYLPPLTVEDLLKQIEYLLRSKWVPCLEFSKVGFVYRENHRSPGYYDGRYWTMWKLPMFGCTDATQVLKELEEAKKAYPDAFVRIIGFDNVRQVQLISFIAYKPPGCEESGGN
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic 1, RuBisCO small subunit 1, Ribulose bisphosphate carboxylase small chain C, RuBisCO small subunit C.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRUA_THET2
Sequence: MRRLLLLCEYDGTLFAGLQRQGRGLRTVQGELERALPGIGALPKAVAAGRTDAGVHALAMPFHVDVESAIPVEKVPEALNRLLPEDLKVVGAREVAPDFHARKDALWRAYRYRILVRPHPSPLLRHRALWVRRPLDLEAMEEALSLLLGRHNFLGFAKEETRPGERELLEARLQVAEGEAGLEVRLYFRGKSFLRGQVRGMVGTLLEVGLGKRPPESLKAILKTADRRLAGPTAPAHGLYFVEAAYPEEKLSP
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: SYM_ACIF2
Sequence: MKRRILITSALPYANGPIHLGHLVEYTQTDIWARYQRLRGHDCVYVCADDAHGTPIMLRAQSEGITPEELITRMHGDHLRDFTGFGIRFDLYHSTHSPENFEISQSIYRALRAADYINVREIEQAYDPVAGIFLPDRFIRGTCPRCGAADQYGDSCEVCGATYSPTDLINPVSAVSGAVPERRNSEHYFFQLGDFSDFLRRWIHSGTLQEEVAHKLDEWFSIGLSDWDISRDAPYFGIPIPDAPGKFFYVWLDALPGYMAATQHWCAAHGRNLADYWGPDSAAEIYHFIGKDIIYFHGLFWPAMLKGSGHRLPTGIFAHGHLTVNGAKMSKSRGTSITARQYLQHLNPEFLRYYIATKLNSHVEDIDLNLEDFLLRGNGDLVGKVVNLASRAAGFIHRSFAGRLAASLGKDQAFYDGLLQTQEAIGEAYAGREYGKAMRDIMALADQINAYVDQNAPWTLAKDPAQHESLHRVVTVTLNGFRVLITLLSPVLPELSRKALEFLQCELDWAGLSKPLLDHQILPYSHLLQRMEKTQVDALIQNPAESPATAPGTAAAPVPTPVPAEAREENPFIGIDDFSKVDLRIARIVAATNVDGADKLLHLTLDIGEGTRSVFAGIKSAYDPASLVGRLTVMVANLAPRKMRFGLSEGMVLAASGPEGGPFLLSPDSGAQPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRLF_FUNXX
Sequence: MALSPSSDAILSIRSSCDRCRSQKLKCIVIETPSGTACCQRCARAMVPCIFGRRSRSKRTTTTTTTTTTDSGRKQRRREPAAALNVLDSCAAPELAASSSSTNAHFPRGINGGMGIPEDRENQETGTFPFYAGCYGGSAPVTSAVEVIQGRKDPDRNLFRYAFQEESTIGDLGLFTHDMSLFGQTLDDASLANTEVMPPSLTESDGISSPGESAPFRVHLPLSEPGVAARVLLSFASDLHERLETLQNGPWQQEESSMGLDGYPIGSVLHLSLTLTDLGVALQKARSNDDASVSASSHKMDDGQTERVNPNSTQAGGISTSTTTEPPCYDTSVSLMLLSCYVTLLRVCTVVLGNFQTYLHLQPRARPKASPASIYPSSASCLGDLLPINQPHHRIHAAVCLLLDSLEQVEEALSLPYQVRCASAVQASSDPGSCTPSEAKPFSDAPAGAAGRDSATTLIHWGFQTSAAGMQDASSELRQKVEGVKEMLRQQMGL
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of pyrrolocin (PubMed:25226362).
What are the official names of this protein?
Pyrrolocin cluster transcription factor fsdR, Pyrrolocin biosynthesis protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL35_BRUA2
Sequence: MPKMKTKSAAKKRFKITGTGKVKAAAAGKRHGMIKRSNKFIRDARGTMVLADADAKIVKQFLPNGL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: Y1811_METBU
Sequence: MAKDILIHQIIEVLERAGFMVSNQCNIRPRSFDLAARQGNTLLFCKVLYNIDGLNEETAREMKSLAKYLNGYPILIGAKTRDQLLEDSVVYMRYDIPALSIQTLYDYFVENVPPLVSAAPGGLYVSIDGDVLKEARMNVSMSLGALASELGVSRRTISKYEEGQMDASIDIVLHLEEILDMALAKSIDILRSFEKELDPANVKEEAHEMKTPPNDNILNLIYTLGYDVLSTNQAPFKAVSKDTSSTFLTGVSEYSNAMVKRAHLMSSISNVIETQSVFIIEGKSRYKFVEDTVLIERDELNTIADSDDLDTLIHERAKRHKEE
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein Mbur_1811.
Protein: RL3_DINSH
Sequence: MRSGVIAKKVGMTRLFMEDGKQVPVTVLQLDKLQVVAQRTAEKDGYSAVQLGAGTAKAKRTTKAMRGHFAAASVEPKRKVAEFRVAPENLINVGEEITADHYFEGQYVDVSGTSIGKGFAGAMKRHNFGGLRASHGVSISHRSHGSTGQCQDPGKVFKGKKMAGHMGAARVTTQNLQVVRTDADRGLIMIKGAVPGSKGGWVTIKDAVKKPVPENVILPAALKSAAEEAKRLAEEAAAAAEAEAKAAEEAAAAEAAAAEEAALKQAEAQIEAEKKEGDE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: HIS7_PSEU2
Sequence: MAERKAYVERNTLETQIKASINLDGTGKARFDIGVPFLEHMLDQIARHGLIDLDIECKGDLAIDDHHTVEDVGITVGQAFSQAIGDKKGIRRYGHAYVPLDEALSRVVIDFSGRPGLQMHVPYTRATVGGFDVDLFQEFFQGFVNHANVTLHIDNLRGTNTHHQIETVFKAFGRALRMAVELDERMAGQMPSTKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2BE_STRPU
Sequence: MAPTAQVAKKGSKKAVKGTKTAXGGKKRNRKRKESYGIYIYKVLKQVHPDTGISSRAMVIMNSFVNDIFERIAGESSRLAQYNKKSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYTTSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B, embryonic.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RTCB_NANEQ
Sequence: MDIKLRKIDKYIWEIPKEGKMNVPVRIYASDKLIEKMKEDRTLIQARNVSMLPKIVKHMVVMPDGHEGYGPPIGGVGAFSLDNPPVIPGFVGFDINCGVRLLRTNLTIDEIKDRLNLLVNEIFRNVPAGVGEGGKLKLSIDELNKVLDYGVNWAIDNGFGWEEDRNRIESHGYLDFADSDAVSNTAKQRGKDQLGTIGSGNHFLEIQVVDQIYDEEIAKAFGIYEKNQVTVLIHTGSRGLGHQVASDYLRLFEKKYKYDVPDRELIYAPYDSKDAQNYLKAMAAAANFAWANRQLITYWVRKSFEKVLRKNIESIGLEIVYDLAHNIAKFEEHTIDGKKQKLIVYRKGATRAFPPGHKELWGEYKKYGQPVIIPGSMGTASYLLVGQPKAMELSFGSSAHGAGRQLSRVKAKKLYSYSEVIRKLREMGIIVKSTTKTGVLEEIPEAYKDIDEVVRVTHELGISKIVARFRPVAVIKG
What is the function of this protein?
Essential for tRNA splicing and maturation.  Acts by directly joining spliced tRNA halves to mature-sized tRNAs.  Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
What are the official names of this protein?
tRNA-splicing ligase RtcB, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
Protein: GUAA_XYLFT
Sequence: MTPNIHHDKILILDFGAQYTQLIARRIREIGVYCEVWPWDHSPEEILSFGAKGIILSGGPESTTSPGAPAAPQHVFDSDLPIFGICYGMQTMAVHLGGATEAADKREFGHASVQVIYPDTLFSGLSDHPSEFRLDVWMSHGDHVSRVPPCFTITAATDRIPIAAMSREDKRWYGVQFHPEVTHTLQGQALLRRFVVDICGCQTLWTSANIIEDQIARVRERVGCDEVILGLSGGVDSSVVAALLHKAIGSQLTCVFVDTGMLRWGEGDQVMAMFAEHMGVNVVRINAASRYFDALQGVYDPEAKRKIIGNLFIQIFEEEASKRKQAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEQMTLGMVEPLRELFKDEVRRLGVALGLPHAMVYRHPFPGPGLGVRILGEVKPEYAELLAKADSIFIDELHQADLYDKVSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETVDFMTAHWAPLPYDFLSTVSNRIINELRGVSRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: CUPC8_CANPG
Sequence: EVLLEGPSGVLFKDGQKKYLPPGVKIVLLSKAGAVLSNGDNVQF
What are the official names of this protein?
Cuticle protein CP463, CPCP463.
Protein: RS14Z_STAS1
Sequence: MAKTSMVAKQQKKQKFQVREYTRCERCGRPHSVYRKFKLCRICFRELAYKGQIPGVRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: FER3L_HUMAN
Sequence: MAAYPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEGDPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
What is the function of this protein?
Transcription factor that binds to the E-box and functions as inhibitor of transcription.  DNA binding requires dimerization with an E protein.  Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity).
What are the official names of this protein?
Fer3-like protein, Basic helix-loop-helix protein N-twist, Class A basic helix-loop-helix protein 31, bHLHa31, Nephew of atonal 3, Neuronal twist.
What are the subcellular locations of this protein?
Nucleus.
Protein: METN_CORJK
Sequence: MASDAQPSVDQPSAGTPGATGNSTGTTGTEIVFRDVTKIFKQGKKEIHALQDINTQIPAGSIVGIIGYSGAGKSTLVRQINGLDRPTSGQILLDGQDIVPLPESQMRKLRSDIGMIFQQFNLFSSRNVAGNVAYPLRLQGMPKQQREERVKELLEFVGLSDKGKAYPEQLSGGQKQRVGIARALATNPSLLLADEATSALDPSTTRDVLELLRKVNRELGITIVVITHEMEVVRSIADSVIVMESGRIVEQGSVYEVFSNPQTKTAANFVATSLRNTPDMVEAEALQSENGRLFTVTMAEGIGFFDAISKLSAAGVTVNIVHGGVTTLQNHSFGRLTLRLTAHSTDGEKAIEEFHSHMQDSTEIEEIR
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GLNE_NITOC
Sequence: MNWQANIHKLPALLQGRLKNDLARFQEALEQKNLDTVFKAKTLKTLCLVWGASEFVATNCIRWPSLLLDLQGSGNLFRAYEPNHYVKSLAQQLTNISTETELMVVLRRFRQREMVRIVWRDLAGWASLDEVFRELSQLAEACLNSALACLHYWQSQALGTPYGSISGKPQSMVVLGMGKLGARELNLSSDIDLIFAYPESGETRGAQRTLNNEEYFIRLARRLIRVLDERTEEGFVFRVDMRLRPDGDSGPLVASFNAMENYYQNQGRDWERYAMIKARVVAGDCQAGTRLMAMLRPFSYRRYLDFGAIESLRSMKAMIAQELRRQGIKANIKLGPGGIREVEFIGQSFQLIRGGRESALQERGILRVLTLLAERDHLPYYAKEELCAAYVFLRRVEHRLQAYRDEQTHDLPTSTEGRVRLAFAMGYRDWEAFASALEEHRRRVQEHFEQLFAAPHMDITDQMAQEKRLAEVWLGGELREASLAVLSAAGYRAPEEAVQTLMYLRQSYTVRALSAQARIRLDRLMPLLLGAVGRTEYPEQCLQRVIILLETVAQRTAYLALLAEYPMALSQLVKLCAASPLIARQLTRYPLLLDELLDPRSLYQVLGYDSLAEDLKWSLESIPGDDLEQQMELLRHFCQRQTLRVAAADVTGVLPLMKVGDHLTYLAEVILKKALELSWRHLVHRHGRLQSSTGEQPEESGFAVIGYGKLGGYELGYGSDLDLVFLHNAKPGDPPSEGKKPLDPVVFYSRLGQRLIHILQTSTPSGKLYEVDTRLRPSGVSGLLVSGLDAYRGYQCMQAWTWEHQALVRARFVAGDARLGAAFTAMRQEILGRQRDPIKLRDEVRHMRAKMRNQLDRSQGGWFDLKQGRGGIADIEFIVQYGVLAWAHAHPQLLEYPDNIRILEGFAQAGLLASEESQLLADAYRAYRAAANRLNLQTHEARVEEGQFRQERIAVQQLWSALLEDESAK
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: UVRC_THET8
Sequence: MRAQDLPPLPETPGVYLWKRGEEVLYVGKAKSLRARVKSYFHAEGKARRIAEEATGLDFIATRDEVEALLLEANLIKAHRPLYNVLLKDDKHYPFLKLTNEPFPTLLVVRRVEEDGAKYYGPFPEAGALRRIKTLIDRLFPLRKNSGYPMKRRRYPCLNYSMGRCLAPCVGKADPEAYQEVVRQVEAVLEGRVDGLLQELEAKMREAARRLEFERAAEIRDQMEALRAFFSTDQQAFDPEMGDLDFLGMARSGALAVVQLYQVRSGRILGRISRVVEKEEATDEEILWAFLRDHYLEASPLPPLVLLPFPLEDLESLAELLKRRAGRKVELRVPKKGEKARLLELAERNARLALETELKLRERRGEHPALKALQDLLGLPARPWRLEGYDISHLQGQARVFSIAVFEGGRPKRQEYRRMRLKAGNDDYAAMEEGVFRRYTGSLKDLPLPDLLLIDGGVGQVRAAARALERAGLRLPLVGLAKGEEVLVTPEGRELRLPLTHPALQLLIHLRDEAHQNGLRYHRKRRSEELFRVLQGIPGIGEKRRRLLLERYGGLRALKEAPLEELARLPGMSLEAARALKAALAEEEPA
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSF_PROMP
Sequence: MAQQTIESNNKKSVNRGKDIAKDTILTPNFYTTDFEAMEKMDLSINEDELEAICEEFRKDYNRHHFVRNKEFEGAADKIDAETRELFVDFLEGSCTSEFSGFLLYKELSKRIKDKNPLLAECFAHMARDEARHAGFLNKSMNDFGLQLDLGFLTANKDYTYFAPRAIFYATYISEKIGYWRYIAIYRHLEKNPSGKIFPLFNFFENWCQDENRHGDFFDALMKAQPRTVKSLSQKIEIFGYTLKHPIFDYYHRFRYFLNNHPIVSKLWSRFFLLAVFATMYIRDLGTKRNFYGALGLNAREYDQFVINKTNETSAKVFPVVLNVYDKSFYKRLDRIVENGTRLSEIDKKENPNVIKVLSKLPIFISNGYQLIRLYLLKPLESDDFQPSIR
What is the function of this protein?
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis.  Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).
What are the official names of this protein?
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, Mg-protoporphyrin IX monomethyl ester oxidative cyclase.
What is the protein family that this protein belongs to?
Belongs to the AcsF family.
Protein: NHR42_CAEEL
Sequence: MTRQTTSQTCLICGDSADSLHFGALSCRACAAFFRRKVAGRRNIFRRCDRQCKVDTGMRKLCASCRYDKCLKVGMRESAVLSRLAKKNQNYKKSIVGSPDAYEPSTSTSDSVLENLQSAYHKLEETRKRVFNISETHVSQCCNYKRMNDVFFEDIKLVMEHLLETFKKSDISQEQEKLLCVHFMVPFILFEGGYKSTNSDLFYLPSGDFIDENRIEEYYSNPDDQNDNSAKSAAEVFRPYWKLNKQTLKTHLDDVQLDLPEFLFITALIYFDDGLLDQNEECIEVCKQMKAKIIEELTDYEKNVRINEDHSYRVGQIIMVLHGIQRTMNMIHETKEISLVYNVYDMHSSIFGNMAE
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-42.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PERE_HUMAN
Sequence: MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWRGT
What is the function of this protein?
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils.  Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
What are the official names of this protein?
Eosinophil peroxidase, EPO.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. XPO subfamily.
What are the subcellular locations of this protein?
Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
Protein: CAPS2_AFV1Y
Sequence: MVNKKYRQDSKDRYQYKQYIYRSIGGIVPPEMAETVTANQTAQWEAGFTPYHKLRLAIKEICKTDGIPNIKWGMYIAFGEKLLKSYLKMKAGSASSDMIAEYINNAISAFSSRTGISQETAQKIADFITSNY
What is the function of this protein?
Self-assembles to form a helical, filamentous nucleocapsid mesuring 900 nm in length and 24 nm in width (PubMed:19934032) (Probable).  Together with capsid protein 1, wraps arounds the DNA and maintains it in an A-form (Probable).  Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable).  This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
What are the official names of this protein?
Major capsid protein 2, MCP2.
What are the subcellular locations of this protein?
Virion.
Protein: GDIB_BOVIN
Sequence: MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPGAPPASMGRGRDWNVDLIPKFLMANGQLVKMLLFTEVTRYLDFKVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDENDPRTFEGIDPKKTSMREVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCCETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIMQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISSAHNVAAQGKYIAIASTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKDIYKRMMGSEFDFEEMKRKKNDIYGEE
What is the function of this protein?
GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins.  By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking.  Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A.
What are the official names of this protein?
Rab GDP dissociation inhibitor beta, Rab GDI beta, Guanosine diphosphate dissociation inhibitor 2, GDI-2.
What is the protein family that this protein belongs to?
Belongs to the Rab GDI family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: PSBN_PELHO
Sequence: METATLVAISISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: POLG_HAVSC
Sequence: MNMARQGLFQTVGSGLDHILSLADVEEEQMIQSVDRTAVTGASYFTSVDQSSVHTAEVGSHQSEPLKTSVDKPGSKKTQGEKFFLIHSADWLSTHALFHEVAKLDVVSLLYNEQFAVQGLLRYHTYARFGIEIQVQINPTPFQQGGLICAMVPGDQGYGSIASLTVYPHGLLNCNINNVVRIKVPFIYTRGAYHFKDPQYPVWELTIRVWSEFNIGTGTSAYTSLNVLARFTDLELHGLTPLSTQMMRNEFRVSTTENVVNLSNYEDARAKMSFALDQENWRSDPSEGGGIKITHFSTWTSIPTLAAQFAFNASASVGQQIKVIPVDPYFYQMTNSNPDQKYITALASICQMFCFWRGDLVFDFQVFPTKYHSGRLQFCFVPGNELIEVTSITLKQATTAPCAVMDITGVQSTLRFRVPWISDTPYRVNCYIKSSHQKGEYTAIEKLIVYCYNRLTSPSNVASHVRVNVYLSAINLECFAPLYHAMDVTSQTGDDSGGFSTTVSTEQNVPDPQVGITTPKDLKGKANKGKMDVSGVQAPVGAITTIEDPVLAKKVPETFPELKPGESRHTSDHMSVYKFMGRSHFLCTFTFNANNREYTFPITLSSTSNPPHGSPSTLRWFFNLFQLYRGPLDLTIIITGATDVDGMAWFTPVGLAVDTPWVEKQSALTIDYKTALGAIRFNTRRTGNIQIRLPWYSYLYAVSGALDGLGDTTDSTFGLVSIQIANYNHSDEYLSFSCYLSVTEQSEFFFPRAPLNSSAMMTSENMLDRIAGGDLESSVDDPRTDEDRRFESHIEKKPYKELRLEVGKQRFKYAREELSNEILPPPRKLKGLFSQSKIS
What is the function of this protein?
Functions as a viroporin.  Affects membrane integrity and causes an increase in membrane permeability.  Involved in host intracellular membrane rearrangements probably to give rise to the viral factories.  Does not disrupt calcium homeostasis or glycoprotein trafficking.  Antagonizes the innate immune response of the host by suppressing IFN-beta synthesis, which it achieves by interfering with the RIG-I/IFIH1 pathway.
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the picornaviridae polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein VP2]: Virion. Host endosome, host multivesicular body. Note=The egress of newly formed virions occurs through an exosome-like mechanism involving endosomal budding of viral capsids into multivesicular bodies. SUBCELLULAR LOCATION: [Capsid protein VP3]: Virion. Host endosome, host multivesicular body. Note=The egress of newly formed virions occurs through an exosome-like mechanism involving endosomal budding of viral capsids into multivesicular bodies. SUBCELLULAR LOCATION: [Capsid protein VP1]: Virion. Host endosome, host multivesicular body. Note=The egress of newly formed virions occurs through an exosome-like mechanism involving endosomal budding of viral capsids into multivesicular bodies. SUBCELLULAR LOCATION: [Capsid protein VP4]: Virion. Note=Present in the full mature virion. The egress of newly formed virions occurs through an exosome-like mechanism involving endosomal budding of viral capsids into multivesicular bodies. SUBCELLULAR LOCATION: [Protein 2B]: Host membrane; Peripheral membrane protein. Note=Probably localizes to intracellular membrane vesicles that are induced after virus infection as the site for viral RNA replication.
Protein: HN_SENDZ
Sequence: MDGDRGKRDSYWSTSPSGSTTKPASGWERSSKADTWLLILSFTQWALSIATVIICIIISARQGYSMKEYSMTVEALNMSSREVKESLTSLIRQEVIARAVNIQSSVQTGIPVLLNKNSRDVIQMIDKSCSRQELTQHCESTIAVHHADGIAPLEPHSFWRCPVGEPYLSSDPEISLLPGPSLLSGSTTISGCVRLPSLSIGEAIYAYSSNLITQGCADIGKSYQVLQLGYISLNSDMFPDLNPVVSHTYDINDNRKSCSVVATGTRGYQLCSMPTVDERTDYSSDGIEDLVLDVLDLKGRTKSHRYRNSEVDLDHPFSALYPSVGNGIATEGSLIFLGYGGLTTPLQGDTKCRTQGCQQVSQDTCNEALKITWLGGKQVVSVIIQVNDYLSERPKIRVTTIPITQNYLGAEGRLLKLGDRVYIYTRSSGWHSQLQIGVLDVSHPLTINWTPHEALSRPGNKECNWYNKCPKECISGVYTDAYPLSPDAANVATVTLYANTSRVNPTIMYSNTTNIINMLRIKDVQLEAAYTTTSCITHFGKGYCFHIIEINQKSLNTLQPMLFKTSIPKLCKAES
What is the function of this protein?
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
What are the official names of this protein?
Hemagglutinin-neuraminidase, HN protein.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Note=Folded in the endoplasmic reticulum.
Protein: GYRB_CYTAU
Sequence: DKDSYKVSGGLHGVGVSCVNALSTDMKVTVYSHGKVHQQEYKKGIPQYDVKEIGESEIHGTKVQFLPDDSIFTSSEYKYETIANRLRELSFLNKGIRITLQDHREVDADGKSEIETFHSEGGLREFVEYVDSTRERLIPRPLYMESDKGPIPVEVAMLYNTSYSENVFSYVNNINTVEGGTHVAGFRRALTRTLKSYADKSGMLEKLKMEVTGDDFREGLTAVISVKVQEPQFEGQTKTKLGNSDVMGAVDQVVGEMLNTYLEENPKEAKIIVQKVILAAQARNAARKAREMVQRKNVLSGSGLPGKLADCSESDPEKCEIYLVEGDSAGGSAKQGRDRKYHAILPLRGKILNVEKAQEHRIYENDEIKNMITALGVSFGTEEGEKVLNLTKLRYHKVIIMTDADIDGSHIRTLILTFFFRYMRALIDGGHVYIAQPPLYLVKRGKEEKYCWTEEQREVAVKELAKDGKEDSVGIQRY
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.