PharMolix/UniProtQA huggingface dataset:
Protein: SUMO1_MOUSE
Sequence: MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2.  Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1.  Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.  May also regulate a network of genes involved in palate development.  Covalently attached to ZFHX3 (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 1, SUMO-1, SMT3 homolog 3, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Smt3C.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus. Note=Recruited by BCL11A into the nuclear body (PubMed:18681895). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (By similarity).
Protein: TCP4_HUMAN
Sequence: MPKSKELVSSSSSGSDSDSEVDKKLKRKKQVAPEKPVKKQKTGETSRALSSSKQSSSSRDDNMFQIGKMRYVSVRDFKGKVLIDIREYWMDPEGEMKPGRKGISLNPEQWSQLKEQISDIDDAVRKL
What is the function of this protein?
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery.  May be involved in stabilizing the multiprotein transcription complex.  Binds single-stranded DNA.  Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
What are the official names of this protein?
Activated RNA polymerase II transcriptional coactivator p15, Positive cofactor 4, PC4, SUB1 homolog, p14.
What is the protein family that this protein belongs to?
Belongs to the transcriptional coactivator PC4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL25_COXBR
Sequence: MAAESFELIAELREFTGKSAARRMRRFEDKVPGTVYGAGKAPQSITLLQKDLLKALESESTFSSILTLKVGDKKQKVILKALQRHHTKPKIVHIDFQRIKASEKLIMNVPLHFLGEDDCPGVEAGGVVSHLQSEVEIRCLPADLPEYIEVDLSHLQLDESVHLSNLKLPAGVGLTSAVDEEHDSPIASVHMPRVSKADVEAEAAEAALAKEAATEAAEEEETEKPASEAEASGEAEQADTDKKE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: EFTU_MYCSY
Sequence: AKLDFDRSKEHVNVGTIGVH
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMP10_HUMAN
Sequence: MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR
What is the function of this protein?
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5.  Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors.  Inhibits endothelial cell migration and growth.  May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
What are the official names of this protein?
Bone morphogenetic protein 10, BMP-10.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: UPP_YERPN
Sequence: MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYVATADLETETVTIEGWNGPVEIEQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGVYRDEETLKPVPYFQKLVSNINERMALVVDPMLATGGSMIATIDLLKKAGCQSIKVLVLVAAPEGIKALEEAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: PYRG_PARMW
Sequence: MAKFVFITGGVVSSIGKGIVAASLGRLLKSRGYNVSILKLDPYLNVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFTDTAMSRLNSVTTGSIYQAVINKERRGDYNGGTVQVIPHITGEIRERIHRVAANSNADVVITEIGGTVGDIESLPFLEAIREFSGDVGRNDLAYIHVTLLPFIGTSGELKTKPTQHSVKELRSIGIQPDVLVCRSDRTISEEMKRKIGGFCGVPTRAVIPSLDAESIYAVPLTLEQEGLCREVLDVLDLTDHDSDMAAWQELVHKLRNPGPAVKVALVGKYIQLNDAYLSVVEALRHACIAQDASLDLHWVCAEQIESDGAQALLKGMDAVVVPGGFGNRGVDGKIAAIRWAREQRVPFLGLCLGMQTAVIEWARNQAGLTEATSAELDAGTPHPVIHLLPEQQDVVDLGGTMRLGVYPCRIAPDTLAHRLYGDQVVYERHRHRYEFNNAYRNLFLESGYVVSGSSPDGRLVELIELKGHPFFTACQYHPEFLSRPGRPHPLFQGLIEAAQQRLPSSPVEAIQTQR
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CNBH_COMTE
Sequence: MNAAHLSLAEHAARLRRRELTAVALIDTCAQHHARMEPRLNAYKTWDGARARSAAAAVDTLLDQGQDLGPLMGLPVSVKDLYGVPGLPVFAGSDEALPEAWQAAGPLVARLQRQLGIVVGKTHTVEFAFGGLGVNAHWGTPRNPWSPHEHRVPGGSSAGAGVSLVQGSALLALGTDTAGSVRVPASMTGQVGLKTTVGRWPVEGIVPLSSSLDTAGVLTRTVEDLAYAFAALDTESQGLPAPAPVRVQGLRVGVPTNHFWDDIDPSIAAAVEAAVQRLAQAGAQVVRFPLPHCEEAFDIFRRGGLAASELAAYLDQHFPHKVERLDPVVRDRVRWAEQVSSVEYLRRKAVLQRCGAGAARLFDDVDVLLTPTVPASPPRLADIGTVETYAPANMKAMRNTAISNLFGWCALTMPVGLDANRMPVGLQLMGPPRAEARLIGIALGIEALIGQGHALLGAPDLP
What is the function of this protein?
Involved in the biodegradation of nitroaromatic and chlorinated nitroaromatic compounds.  Catalyzes the conversion of 2-amino-5-chloromuconic acid into 2-hydroxy-5-chloromuconic acid and ammonia.  Also able to catalyze the transformation of 2-aminomuconic acid into 2-hydroxymuconic acid.
What are the official names of this protein?
2-amino-5-chloromuconic acid deaminase, 2-aminomuconate deaminase.
What is the protein family that this protein belongs to?
Belongs to the amidase family.
Protein: CGHF_CHAGB
Sequence: MREHSHGANYVSSVHWAAVLDSISELIDQCQEKEKEKKPVPEDGSIAPQIPGPRLLYEPVKETKAEILASMPARTVVDRMVARYFNALGIAPAILHSAQFLREYESFWKDPDATPFVWIGLLFSVICLAVQFQQPGEEAAEWSSLMRIRQFHDRIVQCLVLGQYTRGGPYVVETMVNYCASELCITKDTDVGPWLPLGIMVPLAVSRGYHRDPAGFPNISPFAGEMRRRVATPPNHATSSTPTSTRTPPTYHPHGPRPKSPLSSTPSPRTESTKSAAPSRDLAADAHDRPYPEILALDKDLQTIETSLPPIFRWQPLSQSFMVPGQVLMFRLWLRLAVLRLVIWLHRKYLAPAYSAAPYAYSRAACARAALEIAEFQLLLHEETRPGGQLHQMRWMQSSLMQSTFLLGMSVACYWMQLTRTALPGADQDMEMRERIRDRLRDTYPLWLRCSAVSRDAREAAERLRQLPDLQGLLPDVEGQLSAQESPGSGVPACWDIFHGTGRHARALDAVLGDMDRSRKTNADWARV
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of the tetramic acid Sch210972, a potential anti-HIV fungal natural product that contains a decalin core.
What are the official names of this protein?
Transcription factor cghF, Sch210972 biosynthesis cluster protein F.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACP_CYAM1
Sequence: MTEQQILDKVQSIVSEQLGVERSQISPNASFTHDLGADSLDNVELVMAMEEEFDLEIPDSAAEQITTIQQAVDYILQHKKSLSQNNLSQNN
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YL031_MIMIV
Sequence: MKYIVGDYLYLGSKENEINNNFTWLMRYLYREFVLDYDKMKKIYGHIESDNNYDDIYNDNNFRDILYFEPNLMDDDKYIYKYENNINLDNDIDDIVFYEEIKNLILELQVYLSEKTTKRLRVMGITKLKLVNDFGINKYVGGIRDLDWKLHFWPEYTIVNDNYITLHELIIACFKIKSHKFETYHEYFMKFDEFHVFSCVKKKDGLNTMCKEIIAFVNFNHYSSL
What are the official names of this protein?
Uncharacterized protein L31.
What is the protein family that this protein belongs to?
Belongs to the mimivirus L31/R44 family.
Protein: EF2KT_HUMAN
Sequence: MAPEENAGTELLLQSFERRFLAARTLRSFPWQSLEAKLRDSSDSELLRDILHKTVKHPVCVKHPPSVKYARCFLSELIKKHEAVHTEPLDELYEALAETLMAKESTQGHRSYLLPSGGSVTLSESTAIISYGTTGLVTWDAALYLAEWAIENPAVFTNRTVLELGSGAGLTGLAICKMCRPRAYIFSDCHSRVLEQLRGNVLLNGLSLEADITAKLDSPRVTVAQLDWDVATVHQLSAFQPDVVIAADVLYCPEAIMSLVGVLRRLAACREHQRAPEVYVAFTVRNPETCQLFTTELGRAGIRWEVEPRHEQKLFPYEEHLEMAMLNLTL
What is the function of this protein?
Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.
What are the official names of this protein?
Protein-lysine N-methyltransferase EEF2KMT, eEF2-lysine methyltransferase, eEF2-KMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_BACVZ
Sequence: MRIAVSGGGTGGHIYPALAFIKEVQRRHPDVEFLYIGTENGLEKKIVERENIPFRAIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLKEFKPDAVIGTGGYVCGPVVYAAAKMGIPTIIHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPAEKVVFTGNPRASEVVSIKTGRSLTEFGLKDNQKTVLIFGGSRGAAPINRAVIDMQEELKTRPYQVLYITGEVHYEKVTAELKGGKAADNMVTKPFLHQMPEYLQSIDVIVARAGATTIAEITALGIPSVLIPSPYVTANHQEVNAKALSQHDAAIVLKETELSGEKLIAALDKIVMNEETLKDMSERTKSLGVPDAAARLYSIMEDIKK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CNTP4_MOUSE
Sequence: MNMGSVAGAVLKMLLLLSTQNWNRVEAGNSYDCDEPLVSALPQASFSSSSELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLMFSDSGRNWKQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSVVIDLDGKSSLLYRFDQNSLSPIRDIISLKFKTMESDGILLHRAGPAGDHITLELRRGKLFLLINSGDARLTSSSTLINLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGISAPAKSVSLPYKHFHGCLENLFYNGVDVIGLVKEHSPQIITMGNASFSCSQPQSMPLTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLFSELQLVSGSLLLLLSDGKLKLTLYQPGKSPSDITAGAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNFSDLQIDSCGISDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCEAYKHQGNASGFYYIDSDGSGPLQPFLLYCNMTETAWTVMQHNGSDLMRVRNTHSENAHTGVFEYTASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRSWWVGRTNETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADLNEWTNDTGFLSYKEHLPVTKIVITDTGRPHSEAAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITDFIRIELRSPTTVTFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPKIQAAPTDGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPGCRGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLSREMIKFSFRTTRAPSLLLHMSSFYKEYLSIIIAKNGSLQIRYKLNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQFSHIAPLKAALQPGPPAPVTVTGHVTESSCVAPSGTDATSRERTHSFADHSGTMDDREPLTHAIKSDSAVIGGLIAVVIFILLCVSAIAVRIYQQKRLYKRNEAKRSENVDSAEAVLKSELHIQNAVGENQKEYFF
What is the function of this protein?
Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses.  Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism.  Also participates in the GABAergic system.
What are the official names of this protein?
Contactin-associated protein-like 4, Cell recognition molecule Caspr4.
What is the protein family that this protein belongs to?
Belongs to the neurexin family.
What are the subcellular locations of this protein?
Presynaptic cell membrane; Single-pass type I membrane protein. Note=Specifically present within the presynaptic compartment of synapses.
Protein: HBB_NOTEU
Sequence: MVHLTAEEKNAITSLWGKVAIEQTGGEALGRLLIVYPWTSRFFDHFGDLSNAKAVMSNPKVLAHGAKVLVAFGDAIKNLDNLKGTFAKLSELHCDKLHVDPENFKLLGNIIVICLAEHFGKEFTIDAQVAWQKLVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ISPD_PSE14
Sequence: MKDFLPAFWAVIPAAGIGARMAADRPKQYLQLGGLTILEHSLLCFLDHPRLKGLVISLAVDDPYWAALPCAKDARIQRVDGGSERSGSVLNALLHLHAQGASDNDWVLVHDAARPNLARSDLDNLLGELADDPVGGLLAVPARDTLKRADSSGRVLETVDRSLIWQAFTPQMFRLGALHRALADSLVSNVSITDEASAIEWAGQSPRLVEGRSDNIKVTRPEDLEWLRQRRTEFGR
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: ARGC_NEIMB
Sequence: MSKKIKVGIVGATGYTGVELLRLLAAHPDVEVAAVTSRSEAGTAVADYFPSLRGVYGLAFQTPDEAGLEQCDIVFFATPNGIAMKDAPRLIEQGVRVIDLSADFRIRDIPTWEHWYGMTHAAPDLVSQAVYGLSELNREAVAQARLVANPGCYPTCVSLPLVPLLRQCRLKPGMPLIADCKSGVSGAGRKGNVGSLLCEAGDNFKAYGIAGHRHLPEIRQTIAGLQDGIAEGFVFTPHLAPMIRGMHATVYLHLSDGSDPETVLRDYYRDSPFVDILPTGSAPETRSVRGANLCRISIQQAAQSDVWVVLSVIDNLVKGAAGQAVQNMNIMFGLEETHGLDAIPLLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_NITHX
Sequence: MSDIEQERWSRVKGRLRSTVGEDIYSSWFARMDLESVHGESVRMSVPTRFLKSWIQAHYAERVLACWQAELPDVHRIDLMVRSAMRCAAPAKEAPAADPRRPEHGDGRASTELKMVATAPASANHDALGGSPLDPRLTFASFVTGRSNTLAHAAARQVAEGRRGDSIMFNPLYIHAGVGLGKTHLLQAVTWAGNAGTERKVLYLTAEKFMYGFVAALKSQTALAFKEALRGIDVLVIDDLQFLQGKSTQAEFCHTLNALIDAGRQVVVAADRPPSDLESLDDRVRSRLAGGLVVEMGSLGEELRLGILKSRIEVARAHHASFSVPEPVLDYLAKAITHNGRDLEGAINRLLAHSKLNAQPVTLEMAEREVRDLIRPQEPRRIKIEDIQRVVARQYNVSRSDLLSSRRTANVVRPRQVAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIEALVSKDTTLSDEVELLKRQLQE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y701_NITWN
Sequence: MIQVISDVLTPDELKRFRELLGQAQWQDGRATAGHVAVRAKANEQLSHEDSLGQQLSEFLLERLGKISHFIAAALPLKVLPPRFNRYTGGGSYGDHIDNAIFSVPGAGVRIRGDLSATLFLSEPGDYDGGELIIQGEFARHQFKLPAGQMILYPASTFHQVTPVTRGARLAAFFWTQSLVREHSRRALLFELDNTIQALAQDNPEQPAVARLTGLYHNLLREWSET
What are the official names of this protein?
PKHD-type hydroxylase Nwi_0701.
Protein: Y1779_PSEF5
Sequence: MDTKLLDILACPICKGPLKLSADKTELISKGAGLAYPIRDGIPVMLESEARTLTTEERLDK
What are the official names of this protein?
UPF0434 protein PFL_1779.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: Y2147_THIDA
Sequence: MRLIDPDADLEFDPDSVYDGPSKSQKKREVEALQDLGNELVKLPDAQFKRIELPEELREAVAACRKITQNSALRRQRQYIGKLMRGIDPAPIQAQLDAFKGVSATENAKLHQAEKWRDRLIADNEALTIFLDSYPETDATRLRQLIRNARDEAARNKPPKAFREIFRVIREAMQAG
What are the official names of this protein?
UPF0307 protein Tbd_2147.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: HHEX_PATMI
Sequence: MSTLQYPGPPPPSSMNLHNPHMNHHHGLVGPGLAPLSAPNGIQSLNTLHNGSGPPSHTPFYIDNILGSRLNMTGPARPTPTLPSPTFPAHMNSAYNSYYEQAVHPGLAAPTPISYGSGAFSSPPPYPFARGDYPHGLIDRHDPYSKVPGKPFLWNPFIQRPLHKRKGGQVRFSNDQTMELEKKFESQKYLSPPERKKLAKLLQLSERQVKTWFQNRRAKWRRVKQEVPTGKGEGDENSHEKPRDLDRDDFSREQVLSNGAACAFTHGGGSEADSLEEKEA
What is the function of this protein?
Transcription factor that may play a central role in activating or maintaining gene expression in the vegetal pole.  Part of a gene regulatory circuit with Erg and Tgif that operates early in mesoderm development.
What are the official names of this protein?
Hematopoietically-expressed homeobox protein HHEX homolog, AmHEX, Homeobox protein HEX, HEX homeodomain transcription factor.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRMD_NOCFA
Sequence: MKLDVVTIFPEYLEPLRTALLGKAIDKGLISVDVHDLRRWTHDVHKSVDDAPYGGGPGMVMKPTVWGDALDAVCPDDALLVVPTPAGVPFTQATAQRWAAERHLVFACGRYEGIDQRVFDDAARRVRVEEVSIGDYVLIGGEAAVLVMVEAVVRLLPGVLGNQQSHEQDSFSDGLLEGPSYTRPVSWRGLEVPPILLSGDHAKVAAWRREQSLARTRERRPDLLPPESSSD
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_CHLMU
Sequence: MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSILIEAVTNMYSFEEYRNLRFLKAGDGQAGASNNRTGKNGKDFVLKVPEGTLLRDAETGELIHDFTKDGERIVVCQGGRGGKGNVFFKTSTNRAPTKATPGKPGEIRLVELELKLIADIGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLHPSLGLVHQEGYLYQKPWIMADIPGIIEGASQNRGLGLDFLRHIERTRLLLFVVDISGIERSSPEKDLQILIGELLAYKEDLKNKSMVIALNKIDQLLPDEREERLALLKQQFPDQEFILLSGLTGEGVDVLHDLFKSKLSE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_NITEC
Sequence: MINVGIVGGTGYTGVELLRILAQHPKAKLKVITSRQEAGTGVDDLFSSLRGQITLKFSDPLKVDFGKCDVVFFATPNGIAMQQVSALLGSGIKVIDLSADFRIKDVAEWEEWYGMSHTAPELVAEAVYGLPEVNREKIRNARLIANPGCYPTAVQLGFIPLIEAGAVDENHLIADTKSGVSGAGRKAEIHTLYAEASDNFKSYAVAGHRHLPEIRQGLSERSGKPIDLTFVPHLTPMIRGIHATLYARLTRDVDLQALYESRYANEPFVDVLPAGSHPETRSVRGSNFCRIAVHRPRNGDTAVILSVTDNLVKGAAGQAVQNMNIMYGLPEKMGIQHIPLLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_MYCMM
Sequence: MTNDPGSGFAAVWNAVVAELNGEPNTDGDAGTGTTLTSPLTPQQRAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRTPITAALSRRLGQQIQLGVRIAPPPADDDDDSVAAAVEDPGLEASPETSQEVSDEIDDFGENAPNSRQSWPTHFKKRSTDADTSASAGGTSLNRRYTFDTFVIGASNRFAHAATLAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKALAEIVLRDLIADAGTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NLRP9_BOVIN
Sequence: MAESFFSDFGLLWYLEELKKEEFWKFKELLKQEPLKLKLKPIPWTELKKASRENVSKLLSKHYPGKLAWDVTLNLFLQISRDDLWRKARNEIRQKINPYRSHMKQKFQVLWEKEPCLLVPEDFYEETTKIEYELLSTVYLDAFKPGESSPTVVLHGPEGIGKTTFLRKVMLEWAKGNLWRDRFSFVFFLTGREMNGVTDMSLVELLSRDWPESSEPIEDIFSQPERILFILDGMEELKFDLDCNADLCEDWEQPQSMQVVLQSLLQKQMLPECSLLLALSKMGMRKNYSLLKHMKCIFLLGFSEHQRKLYFSHYFQEKDASSRAFSFVREKSSLFVLCQSPFLCWLVCTSLKCQLEKGEDLELDSETITGLYVSFFTKVFRSGSETCPLKQRRARLKSLCTLAAEGMWTCTFLFCPEDLRRNGVSESDTSMWLDMKLLHRSGDCLAFIHTCIQEFCAAMFYMFTRPKDPPHSVIGNVTQLITRAVSGHYSRLSWTAVFLFVFSTERMTHRLETSFGFPLSKEIKQEITQSLDTLSQCDPNNVMMSFQALFNCLFETQDPEFVAQVVNFFKDIDIYIGTKEELIICAACLRHCHSLQKFHLCMEHVFPDESGCISNTIEKLTLWRDVCSAFAASEDFEILNLDNCRFDEPSLAVLCRTLSQPVCKLRKFVCNFASNLANSLELFKVILHNPHLKHLNFYGSSLSHMDARQLCEALKHPMCNIEELMLGKCDITGEACEDIASVLVHNKKLNLLSLCENALKDDGVLVLCEALKNPDCALEALLLSHCCFSSAACDHLSQVLLYNRSLTFLDLGSNVLKDEGVTTLCESLKHPSCNLQELWLMNCYFTSVCCVDIATVLIHSEKLKTLKLGNNKIYDAGAKQLCKALKHPKCKLENLGLEACELSPASCEDLASALTTCKSLTCVNLEWITLDYDGAAVLCEALVSLECSLQLLGLNKSSYDEEIKMMLTQVEEMNPNLIISHHLWTDDEGRRRGILV
What is the function of this protein?
As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation.  In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1.  Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu.  The active cytokines stimulate inflammatory responses.  Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death.  NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 9.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm. Inflammasome.