PharMolix/UniProtQA huggingface dataset:
Protein: DXS_ACAM1
Sequence: MHLSEIVHPNQLHGLSISELKQIANQIREKHLDTVATSGGHLGPGLGVVELTLALYQTLDLDQDKVVWDVGHQAYPHKLITGRYERFHTLRQKDGVAGYLNRRESKFDHFGAGHASTSISSVLGMALARDAKGENFKTVAVIGDGAMTGGMALEAINHAGHLPHTRMLVILNDNDMSISPNVGAMSRYLNKMRLSPPIQFLSDNFEEQLKQLPFGEQVAPDLKRLKGGMKRLAVSKVGAVFEELGFTYIGPVDGHSLEELLATFKEAHLHEGPVLVHVATTKGKGYAIAEQDQVSYHAQSPFNLETGKAKPSNKPKPPSYSKVFAETLIKMAENDIRVVGITAAMATGTGLDKLQAKLPKQYIDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRGYDQIIHDVCIQNLPVFFCLDRAGIVGADGPTHQGMYDIAYLRCLPNMVMMAPKDEAELQQMLVTGINYTDGPIAMRYPRGSGLGVGLMEEGWEPLPIGKAETLRHGDDVLLLAYGTMVNLASQVADMLTEHGVRATVVNARFAKPLDTELIIPLAQKIGQVVTLEEGCLPGGFGSAVLEALMDHQVMAPVTRIGVPDQLVEHATPDQSKAELGLTPAQVAERVLGLLKQKPAPSYVS
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: SECA_SOLM1
Sequence: MLKAIAHKVFGSRNERYLKGLRPLIEAINAFEPQIQALSDDAMRARVAELRQEVAEGRPLDDVLPETFAIVREASVRSLGMRHYDVQLIGGITLHQGKIAEMKTGEGKTLVATLPVVLNALSGKGVHLITVNDYLAKRDAAWMGKLYGFLGLSVGVIVHGLDDQQRQAAYGADITYGTNNEFGFDYLRDNMKFYQEQLVQRPLNFAIVDEVDSILIDEARTPLIISGQAEDSSTLYARVNALIPMLRRETHFTVDEKARTVLLTDEGVARMEDVLKIDNLFDPANITLQHHVLQALKAHHIFQRDVDYVVKDGQVIIVDEFTGRLMPGRRYSDGLHQALEAKELVQVEAENQTLATITFQNYFRMYKKLSGMTGTADTEAVEFREIYGLEVISIPTNKPMVRKDFPDLVYKTQREKFEAIAADVKDLHKRGQPVLVGTVSIEKSELLSDMLKKTGVPHDVLNAKNHEKEAEIVALAGHAGKVTIATNMAGRGTDIVLGPGVTDLGGLHILGTERHESRRIDNQLRGRSGRQGDPGSSRFYLALDDDLMRLFGSDRLKGLMDKLGMEDGEPIENRMVSRAIENAQKRVEAHNFEIRKQLLDYDNVMNQQREVIYSRRRELMGSDEPETFVQEHIEEIVDEIFAPFAALKGEPDPELLEVAAAQIEDILDYKIELADGGEAEKQAVLEAVTGRQRELAETAGAHYKEVARYFLLDSLDRHWKEHLLSMDHLRDGIGLRGYGQKDPKQEYKREGFELFQQLIYNMRDAAIRALSRVRIRAEVQEQEFQHKDETANVQYSGPAESAEDAKKEPKRREAPKVGRNDPCPCGSGKKYKKCHGAK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: PAFA_FRAAA
Sequence: MDRRIFGLENEYGVTCVFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLKNGARLYLDVGSHPEYATPECDSVPDLVTHDKAGERILEGLLVEAERRLREEGIAGDIHLFKNNTDSAGNSYGCHENYLVGRHGEFSKLADVLVPFLVSRQILCGAGKVLQTPRGAVYCISQRAEHIWESVSSATTRSRPIINTRDEPHADAERFRRLHVIVGDSNMSETTMLLKLGSTDLVLRMIEAGVMLRDMTLENPIRAIREVSHDMTCQRKIKLANGREVSALDIQREYYSKAVEFVERRGGDEVAKRVLDLWGRTLLAIETDDLELVAREIDWVTKYVLIERFRHKHGLSLASPRVAELDLKYHDIHRDRGLYYRMERAGLVERVTRDLDVFEAKSRPPQTTRARLRGEFIKRAQEKRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVDKLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: LOLD_PHOLL
Sequence: MNNQPLLLCNNLCKKYQEGQVLTEVLKNVTFAINQSEMMAIVGSSGSGKSTLLHLLGGLDTPTSGEVLFKGHSLNKMSSGARAELRNHELGFIYQFHHLLPDFNAVENVAMPLLIGGKNRGQAQKKAFEMLAAVGLEKRAHHRPSELSGGERQRVAIARALVNEPSLVLADEPTGNLDLRNADSIFALLGELNRQQGTAFLVVTHDLNLAGRLNRQVEMRDGYLQDELTVTGAL
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CARB_VIBVU
Sequence: MPKRTDIQSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPDMADATYIEPIQWEVVRKIIEKERPDAVLPTMGGQTALNCALALEKHGVLAEFGVEMIGATADAIDKAEDRSRFDKAMKSIGLECPRADTAKTMEEAYKVLDMVGFPCIIRPSFTMGGTGGGIAYNKEEFEEICRRGLDLSPTNELLIDESLIGWKEYEMEVVRDKADNCIIVCSIENFDPMGIHTGDSITVAPAQTLTDKEYQLMRNASLAVLREIGVETGGSNVQFGINPKDGRMVIIEMNPRVSRSSALASKATGFPIAKIAAKLAVGFTLDELQNDITGGATPASFEPTIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRNQQESLHKALRGLEVGATGFDEMVDLDSPDALTKIRHELKEAGAERIWYIADAFRAGMSVDGVFNLTNIDRWFLVQIEEIVKLEEQVKAGGFAGLTQDVLRQMKRKGFSDARLSKLLGVAESEIRRLRDQFDIHPVYKRVDTCAAEFSSDTAYMYSSYDDECEANPTDKEKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLAIARVEKPKGVIVQYGGQTPLKLARALEAAGVPIIGTSPDAIDRAEDRERFQQAVDRLGLLQPENATVTTMEQAVEKSREIGFPLVVRPSYVLGGRAMEIVYDEQDLRRYFNEAVSVSNESPVLLDRFLDDAIEVDIDAICDGERVVIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDKMREQVEKLAFELGVRGLMNTQFAVKDNEVYLIEVNPRAARTVPFVSKATGAPLAKIAARVMAGQSLESQGFTKEIIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGATFAEAYAKAELGCGNVYPEGGRALLSVREGDKQRVVDLASKLLKLGYKLDATHGTAVILGEAGINPRLVNKVHEGRPHILDRIKNNEYTYIVNTAAGRQAIEDSKVLRRGALAEKVNYTTTLNAAFATCMSHTADAKASVTSVQELHAQVQASLKA
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: CAPZB_PIG
Sequence: MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.  Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).  Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (PubMed:36071160, PubMed:25814576, PubMed:29420470, PubMed:33734450).  Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit beta, CapZ beta.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.
Protein: KYNB_BURCJ
Sequence: MDTLWDISPPVSPATPVWPGDTPVAVERVWRMEAGSPVNVARLTLSPHTGAHCDAPLHYDADGAPIGAVPLDTYLGPCRVIHCIGAAPVVRPADVEAALDGVPPRVLLRTYARAAVEQWDSNFCAVAPDTVDLLAAHGVKLIGIDTPSLDPQESKTMDAHRRVRAHRMAILEGIVLDDVPPGDYELIALPLKFATLDASPVRAVLRALPAQAS
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: TLP1_ARATH
Sequence: MSFRSIVRDVRDSIGSLSRRSFDFKLSSLNKEGGKSRGSVQDSHEEQLVVTIQETPWANLPPELLRDVIKRLEESESVWPARRHVVACASVCRSWRDMCKEIVQSPELSGKITFPVSLKQPGPRDATMQCFIKRDKSNLTYHLYLCLSPALLVENGKFLLSAKRIRRTTYTEYVISMHADTISRSSNTYIGKIRSNFLGTKFIIYDTQPAYNSNIARAVQPVGLSRRFYSKRVSPKVPSGSYKIAQVSYELNVLGTRGPRRMHCAMNSIPASSLAEGGTVPGQPDIIVPRSILDESFRSITSSSSRKITYDYSNDFSSARFSDILGPLSEDQEVVLEEGKERNSPPLVLKNKPPRWHEQLQCWCLNFRGRVTVASVKNFQLIAANQPQPQPQPQPQPQPLTQPQPSGQTDGPDKIILQFGKVGKDMFTMDFRYPLSAFQAFAICLSSFDTKLACE
What are the official names of this protein?
Tubby-like F-box protein 1, AtTLP1.
What is the protein family that this protein belongs to?
Belongs to the TUB family.
Protein: Y2116_SULIM
Sequence: MKITPIAFESLGVRSQATLIETKDLRVLVDPAISLAPRRYNLPPHQREVDRLTELAKVLVDVAKDVDVIIVSHYHYDHHDPGYVIPTDIYKNKLVFIKDPQNMINNSQKYRRAPRFLRSIKDKPSKIEIADGKTFEVGHTTISFSPAVPHGADERLGYVIQVAISDKDSTVIFTSDIEGAPKDVHLKFTKEKMPKTIIIDGPLSYLLGRVLKEEELEKSIRNMEEIVKNGLETVIIDHHVLRDINYAEVLKPVYDIAKDLGVRVTTAAEYLNLEPLILEARRKELFKEDNRPARLPRGLANLLSAGEG
What are the official names of this protein?
UPF0282 protein M1425_2116.
What is the protein family that this protein belongs to?
Belongs to the UPF0282 family.
Protein: CVFC_STAAM
Sequence: MEILRIEPTPSPNTMKVVLSYTREDKLSNTYKKVEETQPRFINQLLSIDGITSIFHVMNFLAVDKAPKADWEVILPDIKAAFSDANKVLESVNEPQIDNHFGEIKAELLTFKGIPYQIKLTSADQELREQLPQTYVDHMTQAQTAHDNIVFMRKWLDLGNRYGNIEEVMDGVLEEVLATYPESQLPVLVKHALEENHATNNYHFYRHVSLDEYHATYNWKTRLRMLNHFPKPTFEDIPLLDLALSDEKVPVRRQAIVLLGMIESKEILPYLYKGLRDKSPAVRRTAGDCISDLGYPEALPEMVLLLDDPQKIVRWRAAMFIFDEGNAEQLPALKAHINDNAFEVKLQIEMAISRIENGDEALGSVWKQMANRTI
What is the function of this protein?
Required for hemolysin production.
What are the official names of this protein?
Conserved virulence factor C.
What is the protein family that this protein belongs to?
Belongs to the CvfC family.
Protein: EXBD_MANHA
Sequence: MKKFDEINIIPFIDIMLVLLAIVLVTASFISQGKIQVNVPKASTTQPMKADDLAKLLTITENNEFFFNDQAITKEQLIAEVATWDKSQKVSLKVDGAVAFEKFVELTDILSANEIKNVAIITKKETAPAPSSTPGSPAQVPAVAP
What is the function of this protein?
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
What are the official names of this protein?
Biopolymer transport protein ExbD.
What is the protein family that this protein belongs to?
Belongs to the ExbD/TolR family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: NF2IP_HUMAN
Sequence: MAEPVGKRGRWSGGSGAGRGGRGGWGGRGRRPRAQRSPSRGTLDVVSVDLVTDSDEEILEVATARGAADEVEVEPPEPPGPVASRDNSNSDSEGEDRRPAGPPREPVRRRRRLVLDPGEAPLVPVYSGKVKSSLRLIPDDLSLLKLYPPGDEEEAELADSSGLYHEGSPSPGSPWKTKLRTKDKEEKKKTEFLDLDNSPLSPPSPRTKSRTHTRALKKLSEVNKRLQDLRSCLSPKPPQGQEQQGQEDEVVLVEGPTLPETPRLFPLKIRCRADLVRLPLRMSEPLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVVLTSSPEATETSQQLQLRVQGKEKHQTLEVSLSRDSPLKTLMSHYEEAMGLSGRKLSFFFDGTKLSGRELPADLGMESGDLIEVWG
What is the function of this protein?
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2.  Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity).  Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
What are the official names of this protein?
NFATC2-interacting protein, 45 kDa NF-AT-interacting protein, 45 kDa NFAT-interacting protein, Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
Protein: SC231_SCHPO
Sequence: MNFEEIEERDGVRFTWNVFPSTRIESSRTIVPIASIYKPLNERPDLPPVLYEPVTCKAPCKAVLNPYCHIDTRAKFWICPFCLQRNMLPPQYKDISNTSLPIELLPEYSTIEYTLPRPPQLTPVFLFVVDVCQDEENLQALKDSLIISLSLLPPECLVGLVTFGTMVDVYELGYTECSKSYVFRGSKDYTSKQIQEMLGLPTSNVSPVALQQARSFQGSAAPSRFLLPIQQCEFQLTNILEQLQPDSWPVANDRRPQRCTGTALNISVSMMESVCPNSGGHIMLFAGGPSTVGPGTVVSTELREPIRSHHDIERDQAKHVKKALRFYEGLTKRVSANGHAVDILAGCLDQIGIMEMKSLASSTGGYLVLSDSFTTSIFKQSFQRIFGRDSLNNMLLGFNATMEVLTTKELKISGLIGHAVSLNKKSQNVGDIEIGLGNTNSWKMCGISPKSTYAIYFEVATQSASAPQGDSRGLVQYLTLYQHSSNTFRLRVTTVARAFADGGSPLIVNSFDQEAAAVAMARIAAFKAEVDDGPDVLRWTDRMLIKLCQKFAEYRKDDPSSFRLSSQFTLYPQFMYYLRRSPFLQVFNNSPDETAFYRHMLNHEDVNNSLIMIQPTLQSFSFEHPGGVPVLLDAVSVKPDVILLLDTFFHILIFHGDTIAQWRNAGYQNQPEYQNLKELLEAPRVEAAELLIDRFPIPRFIVCDQGGSQARFLLSRLNPSETHNTTSMYGAPPAHAILTDDVSLQTFMSHLKKLAVAVS
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein sec23-1.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SAHH_PARP8
Sequence: MNAAVIDSKHSQDFIVADLSLADWGRKELDIAETEMPGLVQIREEYKAQQPLKGARVAGSLHMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIAKGGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVISKPTNEEEVALYKSIARHLDADPVWYSTRLAHIKGVTEETTTGVHRLYQMEKEGRLPFPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATGNYHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYTWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFVEGSKYENKVYVLPKQLDEKVARLHLARIGANLTELTSEQAGYIGVDKNGPFKPNHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_MESM1
Sequence: MVKLRLKRMGSKFNAFYRIVAADARAPRDGRFIEELGYYNPFSKDLKIEKELVFKWLDLGAKPTETTKTLFKKEKIMEQYHQKRQKN
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: AMPG4_RICBR
Sequence: MLITRIFKDYRLFEILILGIVSGMPLAIIFTTISVWLKESGVDIAVITTFGIAKLSYSLKVFWSPLIDNFKVPFLSRWGHRKGWLILCSSLMALVLIAMGRENPAASLTALYFLTIALGFLSSTFDIAVDALRIDKFEEETQGIASATAVFGYRIGMLITGGWALYFAEITNDNWQLTFFVIGIIFAVSTIFIITVKEKELVREKIKFTSIASWIHTVISPFKDFFKREFAITILFAVIFFKLGDSMLLSIASPFYIELGYTKSEIAVIVKLYGLIATLVGGFVGGIVMYRFNNFKGLIITGILQSITHFAFIWLNGQPPSFGALLITITIENFAAAMGTTALVGYISYLCNKKYSATQYALFTAASSLCNNTVTIYAGKLVNMLGWNGFFIFTIILALPALFILMYLNKKVNV
What are the official names of this protein?
Putative transporter AmpG 4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HS90B_CHICK
Sequence: MPEQVQHGEDEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDTGKDLKIDIVPNPRDPTLTLLDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRTDHGEPIGRGTKVILYLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYVEKEREKEVSDDEAEEEKVEKEEEESKDEEKPKIEDVGSDEEEEEGEKSKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFTELAEDKENYKKFYEAFSKNLKLGIHEDSTNRKRLSELLRYHTSQSGDEMTSLSEYVSRMKESQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKTLVSVTKEGLELPEDEEEKKNMEESKAKFETLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKADANKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVIAEESSIAPPDEIPPLEGDEDTSRMEEVD
What is the function of this protein?
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.  Undergoes a functional cycle linked to its ATPase activity.  This cycle probably induces conformational changes in the client proteins, thereby causing their activation.  Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.  Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself.  Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone.  After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle.
What are the official names of this protein?
Heat shock cognate protein HSP 90-beta.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm. Melanosome. Dynein axonemal particle.
Protein: HIS5_SULAC
Sequence: MRAVIIDYGVGNLFSIYSGLRRVGFEVEISKEPKGSEDLIVFPGVGSFSAVSKYLVARKEKFEVLRSNGTGFLGICLGMQIMFEEGTEGGLNKGLGWLKGRVDKINHPRVKIPHIGWDKVNVIKYNELSEGIDDQYVYYAHSYVAYPTDKSVILSTTSYGIDYPAVVNIGNIVGTQFHPEKSSLVGRKFLTNVYRWLRK
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD3_MOUSE
Sequence: MEGRNAAAEPFVWVNSASAHSQSVAKAKYEFLFGKSEEKTPDSSDHGGSTLLPPTVTNEFPEYGTMEEGGEGLRASLDFDAKSPPCRLPGQQAVHLLAGQDSILNSVTEGPNDAPQCHPQEQSLQPIDSLISALKATEARIASGTFQATKVLDKDANFSVYQVDKELSTASHKPQRAHRTFPVGPGKSPDIPLSAEVPTEENLSLHIQEDLSALLPEEAQAHRSQITNYRRQGPLRVPESACPVSSSSAGSHNPVDRVGALREQRSDLGREHPRGYDRGGSMGRQGRIKHVEFQGVEILWTGEEAESRHPPERTASPVSKEFAKRPSHSSPACGVCSTSTHLTGDVWDETCKAPSERPGTSAGTLSPMPLGESGEDDVFLRESKEHLEENFAIQGDKERILDQEEHLRGDDDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSVGGQHDVLSVSADGGIVMGYSAGITNGLHDSANSVYTRGPQEIAFWGSRDRCFAEGKTTGVDAGSEMGSTDILEKETTESLSNGTNSNVEAAKRLAKRLYHLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFLKAFSLVGETQERERVLIHFSNRYFSCNPDTITSKDGVHCLTCAMMLLNTDLHGHVNIGKKMTCQEFITNLQGVNEGGDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSEGTDEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKSLSDEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEIYVSVLKEGGKELLTTDGNEPVGLKKSHSSPSLNPDASPVTAKVKRNVSERKDHRPETPGIKQKVT
What is the function of this protein?
Guanine nucleotide exchange factor for ARF6.
What are the official names of this protein?
PH and SEC7 domain-containing protein 3, Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D, Exchange factor for ARF6 D, Pleckstrin homology and SEC7 domain-containing protein 3.
What are the subcellular locations of this protein?
Cell membrane. Cell projection, ruffle membrane. Postsynaptic density. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions.
Protein: SYC_VIBCM
Sequence: MLKIYNSLTRQKEEFKPIVAGKVGMYVCGVTIYDLCHIGHGRTFVSFDVVARYLRYLGYDLTFVRNITDIDDKIIKRAAENAETCESLTERLIQEMYADFDALNIKRPDVEPRATAYIEEIIALVERLIERGFAYVADNGDVMFEVSQYSEYGKLSKQDLDQLQAGARVDIEAAKRSPLDFVLWKMSKPGEPTWESPWGSGRPGWHIECSAMNSSILGTHFDIHGGGSDLQFPHHENEIAQSCCAHDTQYVNTWMHSGMVMVDKEKMSKSLGNFFTIRDVLGHYDAETVRYFLMSGHYRSQLNYSEENLNQARASLERLYNALRGLDRSVPAAGGEEYVTRFTAAMNDDFNTPEAYSVLFDMAREINRLKSEDMTNASALGSLMRELADVIGILYQEPEAFFQGSAEDEDAAQIEALIKLRNDSRATKDWANADLARDKLNEMGIVLEDGPNGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_ECO7I
Sequence: MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGKVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTH1_ASHGO
Sequence: MSLVHPDTSNYPFRFAPFLRQEYSFSLDPDRPVCQYYNSKEGASSCPNGTLCPNKHVLPIFQNKIVCKHWLRGLCKKNDQCEYLHEYNLRKMPECVFFTKNGYCTQSPECQYLHIDPTSKVQQCEDYRMGFCPLGTACPCKHVKKIICPKYVTGFCPLGRDCDWEHPPFYVPNELSKIRIKRDDEINTKKLDEEKERRLNAIINGELVI
What is the function of this protein?
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
What are the official names of this protein?
mRNA 3'-end-processing protein YTH1.
What is the protein family that this protein belongs to?
Belongs to the CPSF4/YTH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACTN1_CHICK
Sequence: MDHHYDPQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDAQGEAEFARIMSIVDPNRMGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVPGALDYMSFSTALYGESDL
What is the function of this protein?
F-actin cross-linking protein is thought to anchor actin to a variety of intracellular structures.  This is a bundling protein.
What are the official names of this protein?
Alpha-actinin-1, Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, Non-muscle alpha-actinin-1.
What is the protein family that this protein belongs to?
Belongs to the alpha-actinin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction. Cell projection, ruffle.