PharMolix/UniProtQA huggingface dataset:
Protein: 1433G_SHEEP
Sequence: AAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEITAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGG
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.
What are the official names of this protein?
14-3-3 protein gamma, Protein kinase C inhibitor protein 1, KCIP-1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFI1_YEAST
Sequence: MGKFGTTNKSTENLLRDKFVPETSPTNIPTDVLIKQGQITDSTESLIHGGAERYIVNALKPIELNKTEGFFEDPPFHLPSPPVDSTNLEYEDVTDLPKNGLRYDLNDISVEVIEDLYRQIEAFLVHFKLSRSFLQIFKNYVNILIQEGINPLRDEYFTILEDELKGFFTFNSVIEEILEIFLIHPRNKFIALSLAEYTYAKNKIRRHFNHWKTVCELNEEANRFANQAKLRVQEAVFYIWSDKTLKYSQMANDEAESFRNTWLLFRSFQQWITLTQTLKEQSRLADQAFLNKMFRKILKAQEHWKHLETVNTDNIKKIFLRTTFHIWKLRHKEINYHGLERRIFERIKQKVINYEYNKSIAEKVRSFSLQRKYLNKWEKKNIENEDKLGALYELENKFIKQKFFRKLNRSFQHSQQEAIAKSKLNQTLLRCVFEKMWLKRFEDHLHLYSIVSLKEANLVKRIFHSWKKLLYIDLKASDYSRTNLLKSSLRSWKLEVKLKIFEQKCKKSIQASAYRTWRKRIQYGKISSEHVKTAFCAKYLGVWKRRMLQMNSMNDEASKFYEEGLVNECLAIWKERLIKTKELEDRYNFLCKTHAILTVKRTLMHIDNVHLLYTKLAPSMDRVKLSKAFLKWRKATRFKVRHKLNDILHVYEKSKERELQSQLFNAWRNRFCFYTEECNIQAISKRNYQLEKMVLKKFRERLLEIVKSEELADEVREEFVLVKTFYIWKTHLDEIFYMSTLLEQSEANKQFIITSKFLKMWSLRFLKIKRNDETVEVFRHRWDRATVRGLLLLWKNRSDSSPKRRKDFNLKHELKTPIRSDSQNASTIPGSERIKQHRMEAMKSHYSRARRAIPSPVKSSSVLDSTAKKQINLESTTGLNGSPTRGKPLRYSPRRTTRNMPSKVDHIDFGRIPAVPFSLSANSPKIDQDMDYIREHDKSPLSRKRQ
What is the function of this protein?
Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication.
What are the official names of this protein?
Protein SFI1, Suppressor of fermentation induced loss of stress resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the SFI1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole. Note=Spindle pole, half bridge.
Protein: FIBP_MOUSE
Sequence: MTSELDIFVGNTTLIDEDVYRLWLDGYSVNDAVALRVRSGILEQTGATTGVLQSDTMDHYRTFHMLERLLHAPPKLLHQLIFQIPPSRQTLLIERYYTFDEAFVREVLGKKLSKGTKKDLDDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQQHFLLSDRLARDYAAIVFFANNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVDSQVDDMDVDLDKEFLQDLKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMETNFKNLSRGLVNVAAKLTHNKDVRDLFVDLVEKFVEPCRSDHWPLSDVRLFLSQYSASVHSLDGFRHQALWDRYMGTLRGCLLRLYHD
What is the function of this protein?
May be involved in mitogenic function of FGF1 (By similarity).  May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).
What are the official names of this protein?
Acidic fibroblast growth factor intracellular-binding protein, aFGF intracellular-binding protein, FGF-1 intracellular-binding protein.
What are the subcellular locations of this protein?
Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.
Protein: RL6_PSEPW
Sequence: MSRVAKNPVKLPAGVEVKFAGQQLSVKGAKGTLELNVHSSVEVTEESGELRFVARNGDQQARAMAGTTRALVNNMVQGVSQGFERKLQLVGVGYKAQAKGTVLNLALGFSHPVDYELPAGITAETPSQTDILIKGIDKQLVGQVAAEIRDFRPPEPYKGKGVRYADEVVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: CLPC1_MYCTU
Sequence: MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVRSQVEEIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEAAEAGTGGRGGESGSPSTSLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEGAIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVSITDAAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASLRDREKTLVAQRAEREKQWRSGDLDVVAEVDDEQIAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTSDISKPVGLGFSKGGGENDYERMKQKVNDELKKHFRPEFLNRIDDIIVFHQLTREEIIRMVDLMISRVAGQLKSKDMALVLTDAAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVVTVDVDNWDGEGPGEDAVFTFTGTRKPPAEPDLAKAGAHSAGGPEPAAR
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP (By similarity).  Degrades anti-sigma-E factor RseA in the presence of ClpP2.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpC1.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpC subfamily.
Protein: GLE1_RAT
Sequence: MPSDGRCWETLRALRNSSKGRLRYDREWLLRYEDVLEECMSLPKLSSYSGWVVDHILPNTSHHTQENAPSSDNSPSSGSASGLYQSTLKSPVRSSPQSPSPSTPSGTQSAHESPFTEPIALQSSRAIKVEGCIRMYELAHRMRGTEGLRQWQEEQERKVQALSEMASEQLKRFDELKELKLHKEFRDLQEVMEKSTREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQEQLRKEEGQIRLRSLYTLQEEVLQLNQQLDASSQHKDLLNVDLAAFQTRGNQLCGLISGIIRTTLESGYPTAENQAEAERVLQEMRDLLSNLEQEITRASEMKKKDEEEARVKLQESQVQQGPGAPTKTSAPSPSLVGTQSEDLQVKVQDSTMQWYQQLQDASAKCVLAFEDLTSSKDSQIKKIKMDLQKAATIPVSQISTIAGSKLKEVFDKIHSLLSGKPVQSGGRSVCVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASGIWMLHPKVGDLILAHLHKKCPYSVPFYPAFKEGMPLEDYQRMLGYQVTDSKVEQQDNFLKRMSGMIRLYAAIIQLQWPYGSRQEAHPHGLNHGWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQRREIPVPKGFLTPSFWRS
What is the function of this protein?
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.  May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).
What are the official names of this protein?
mRNA export factor GLE1, GLE1 RNA export mediator, GLE1-like protein, Nucleoporin GLE1.
What is the protein family that this protein belongs to?
Belongs to the GLE1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nuclear pore complex. Note=Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function.
Protein: URE3_MYCSJ
Sequence: MRLTPHEQDRLLISYAADLARRRRARGLRLNHPEAVAVITDHLLEGARDGRTVAELMVSGRDVLGRDDVMEGVPEMLHDVQVEATFPDGTKLVTVHHPIP
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAGT_LYMST
Sequence: MYLVVCWGRVTGNMISTRHCFSRCKSRSVRVIKATAMLFVAAMLFLALHMNFSHEASQQNLHRAAPISSPTTISRSTVQIRNATHDFLPASSTPMKDELIETESEFVDGFQRNEVIACSDTSEEFRTDSKRITLVNSQSGVPCPIRPPALAGRFVPSKKSSTYHELAAMFPDVQDGGHYTPRMCTPAEKTAIIIPYRNRCRHLYTLLPNLIPMLMRQNVDFTIFVIEQTTPETFNKGILFNAGYLEALKVDNYDCFILHDVDMIPIDDRNMYRCNKMGPVHFSPGVNKFKYKLFYSGLFGGVVGFTREQFRLINGASNLYFGWGGEDDDLRNRAVHMKLPLLRKTLAHGLYDMVSHVEAGWNVNPHSKGAHSLYDMLNKALGVQAGWNVHPNSKWPLRLFDSVNHAPAEGAGWNVNPDRFKIYSTSRQRQHVDGINSLVYNVTWYRTSPLYTWVGVGFNKTVITNSIPEDLRIGPEADNTYLTGNFTIIS
What are the official names of this protein?
Beta-N-acetyl-D-glucosaminide beta-1,4-N-acetylglucosaminyl-transferase, Beta-1,4-GlcNAcT, UDP-GlcNAc:GlcNAc beta-R beta-1,4-N-acetylglucosaminyl-transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 7 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: VNPD_OXYSC
Sequence: PAAGLSDPKIGNGCFGFPIDRIGSVSGLGCNRLVQNPPKPISGES
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity.  Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).
What are the official names of this protein?
Natriuretic peptide OsNP-d.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: YHEU_SHIB3
Sequence: MLIPWQDLSPETLENLIESFVLREGTDYGEHERTLEQKVADVKRQLQCGEAVLVWSELHETVNIMPRSQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: MMSB_MYCTU
Sequence: MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRARADA
What are the official names of this protein?
Probable 3-hydroxyisobutyrate dehydrogenase, HIBADH.
What is the protein family that this protein belongs to?
Belongs to the HIBADH-related family.
Protein: RGS18_RAT
Sequence: MDMSLVFFSHLNMCESKEKTFFKLMHGSGKEETNIEAKIRAKEKRNRLSLLLQRPDFHGETHTSRSALLAKETRVSSEEALKWAESFDKLLSHRDGVDAFTRFLKTEFSEENIEFWVACEDFKKCTEPQQLILKAKSIYEKFIKNDAPKEVNLDFHTKEVITKSIAQPTLHSFDAAQSRVCQLMEHDSYKRFLKSEIYLHLIEGRPQRPTNLRRRSRSFTYNEFQDVKSDVAIWL
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.  Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha (By similarity).
What are the official names of this protein?
Regulator of G-protein signaling 18, RGS18.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKN6_SCHPO
Sequence: MTTGKPQSFEKMRTPFPGRSKAKGPQSDIIPSAPPNTPVTEH
What are the official names of this protein?
Uncharacterized protein SPAPB1A11.06.
Protein: THIC_FINM2
Sequence: MEYTTQLDAAKKKIITKEMKRVAQKENIDVEILREKIEKGYVVIPANKNHKSLDAHGVGEGLKTKINVNLGISKDCYNIEKEMEKVRVAIDMDAEAIMDLSNYGKTRKFREELIGYSPAMIGSVPMYDCVGMLDKELKDITEEEFLEVVEQHAKDGVDFITIHVGLTRDIAQHLKTTDRITKIVSRGGSLLFAWMIVNNKENPLVTRYDDILEICEKYDVTLSLGDALRPGCINDATDDLQIQELINLSRMAKRAYEKNVQVMIEGPGHVPIDQIEANMKIEKTICNNAPFYVLGPLVTDIAPGYDHITSAIGGAIAASTGADFLCYVTPAEHLRLPNLEDMKEGIIATKIAAHAGDIAKKIPGAKERDDEMSRARFNLDWEKMFELAIDSEKPKKYRKESQPIEEDSCTMCGKMCSMRTVKKVLNGEDVNLI
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: TFP11_MONDO
Sequence: MSLSHLYREGEGAIDEEEDEMENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERELEDERPSFGGKRSRDFSAPVNFISAGLKKAADEADEEDSDEEEKPIKQEDFPKDFGPKKLKTGGNFKPSQKGFVGGAKSFTDFGSWERHTKGIGQKLLQKMGYVPGKGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSVQDFPVVDSEEEAEEEFQKELSQWRKDPSGGKKKPKYSYKTVEELKAKGRIGKKLSAPQKELSQVKVIDMTGREQKVYYSYSQISHKHNIPEDGLQQQQLPLPGKDAKPQAFALPELEHNLQLLIDITEQEIIQNDRQLQYERDMVVNLSHELEKMSEVLSHEETVITNLSKVLEMVEECERRMQPDCSDPLTLDECARIFETLQEKYYEEYRMSDRVDLAVAIVYPLMKDYFKDWDPLKDCTYGTGIIAKWKSLLENDQILSHGGQDLAADAFHRLIWEMWMPFVRNIVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTVPIHSWIHPWLPLMQSRLEPLYSPIRNKLSSALQKWHPSDSSAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLNELIINPHQQHMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSIKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQRGIGMAASSVPMNFKDLIQTKAEEHNIVFMPVIGKRHEGKQLYTFGRIVVYIDRGVVFVQGEKTWVPTSLQSLIDMAK
What is the function of this protein?
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.  Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS).  In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.  May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).
What are the official names of this protein?
Tuftelin-interacting protein 11, Septin and tuftelin-interacting protein 1, STIP-1.
What is the protein family that this protein belongs to?
Belongs to the TFP11/STIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.
Protein: RPOC2_ILLOL
Sequence: MEVLMAERANLVFHNKVIDGTAMKRLISRLIDHFGMAYTSHILDQVKTLGFQQATATSISLGIDDLLTISSKGWLVQDAEQQSLLLEKHHRYGNVHAVEKLRQSIEIWYATSEYLRQEMNPNFRMTDPSNPVHIMSFSGARGNVSQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYTISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHVVVRRTDCGTIRGISISIRNGMTGRILIQTLIGRVLADDVYMGLRCIAARNQDIGIGLVNRFITSRAQPIYIRTPFTCRSTSWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPFNGKIKFNEDLVHPTRTRHGHPAFLCYIDLYVTIESQDILHNVNIPPKSFILVQNDQYVESEQVIAEIRARTSTFSFKEKVRKHIYSDSEGEIHWSTDVYHVPEYTHGNVHLLPKTTHLWILSGGPGPCRRSIVPFSLHKDQDQMNLQSLSVEQRYISNLSVNNDRVRHKLFDLDPFWKKKGGVGYSGPDRILSNGHWDFIYPAILHENSNLLAKRRRNRFIISFQHDQEREKKLPPRSGIKIEIPINGILRRNSILAYFDDPRYRRSSSGITKYGTIEVDSIVKKDDLIEYRGAKELRPKYQMKVDPFFFIPEEVHILPGSSPIMVRNNSIIGVDTRITLNTRSRIGGLVRVERKKKRIELKIFSGDIHFPGETDKISRHSGILIPPETRKKNSKESKSKQLKNWIYVQRITPIKKKYFVSVRAVVIYEIADGIHLATLFPQDLLQERDNLQLRVVNYFLYGNGKPIRGISHKSIQLVRTCLVLNWDQDQNGSIEEVYASFVKVRANDLIRDFIRIDLVKSPISKRNDTAGSGLIPVNGSDRTNINPFCSKARIQSLSQHQGTVRTFLNRNKEGESFLVLSSSNCSRIGPFNGLKYHNLTKKESIQIKEDPMIPIRNSLGPFGTVPKIANFYSSYQLITHNEILLNKYLLLDNPKQTFEALKYYFMDENGIIYNPDPCSNIILNPFDSNWYFPHQDYCEETCTIISLGQFICENVCISKHGPRIKSGQVLIVHVDSLVIRSAKPHLATPGATVHGHYGEILYEGNTLVTFIYEKSRSGDITQGLPKVEQVLEVRSIDSISMNLEKRFEGWGERMTGILGIPWGFLIGAELTIAQSHFSLVNKIQRVYRSQGVQIHNRHIEIIVRQITSKVLVSEDGMSNVFSPGELIGLLRAERTGRALEEAICYRAVLLGITRASLNTQSFISEASFQETTRVLAKAALRGRIDWLKGLKENVVLGGMIPVGTGFKGLVHHSREHNNIPFEIQKKSRFEGEMRDILFPHRELFCSCLETNFHDTSEQSFMGLNDS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL15_THETH
Sequence: MKLSDLRPNPGANKRRKRVGRGPGSGHGKTATRGHKGQKSRSGGLKDPRRFEGGRSTTLMRLPKRGMQGQVPGEIKRPRYQGVNLKDLARFEGEVTPELLVRAGLLKKGYRLKILGEGEAKPLKVVAHAFSKSALEKLKAAGGEPVLLEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: Y024_SIFVH
Sequence: MLTMENRGIRIAERYGYKLVPHFFNLFFILDNWNNIPIGKTIVSLYNYRQKEFVEIFKKYDENIGIATVNYTNVHVIKNHNEFEIIVYNVDSIHDHKSKYLLMLFLGNKFIFRRGKVYLYDIVIRNLIKSHDLQFKIKKINLIRVRSLFGNNIVSYYPKKELIRNSIILGKGANDSIYVITEINNKRVLYYVKRIRKIPRLNRIALKNHKLQYQFFKMLLQKGILQKETLFPIVPLRSLFTSLRISGTSEWKFSPLYVFNGRLVNANIYARAMNPVLIDYDYDETNQVLLKFADESYHSVLCGLDYKNMLWCITLPAITMWWRIKEVYKYVYDLDNQTKVFNY
What are the official names of this protein?
Uncharacterized protein 24.
Protein: TVB27_HUMAN
Sequence: MGPQLLGYVVLCLLGAGPLEAQVTQNPRYLITVTGKKLTVTCSQNMNHEYMSWYRQDPGLGLRQIYYSMNVEVTDKGDVPEGYKVSRKEKRNFPLILESPSPNQTSLYFCASSL
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 27.
What are the subcellular locations of this protein?
Cell membrane.
Protein: MURD_CALBD
Sequence: MDLKGKNVLVVGLGRSGLASARFLKKHGAFVIGFDEKAEEQFKEEKNDAQKLLDEIYYCEIPDEFIDRVQLVIVSPGVPLSKRPLVLAHKKGIEVIGEIELAYRFCKSKNIVAITGTNGKTTTTTLVGEILKKQYEDVVVCGNIGLPFIDTIETSSEDTIFVLEISSFQLETIKYFKPKIGCILNITPDHLNRHLTMENYTKAKMRIFENIDEMGYTVLNYDNNITRDLIGLAKGNVIVFSKTKTQFENVVFVENDVIYFTFEGKTQEVMKKDEIFIPGQHNLENALAAISCTLPFGIEKDTIEQVLKTFRGVEHRIEFVAEINGIKFYNDSKGTNTDAAEKALNAFENPIILIAGGYDKGESFEKFASLVAKKVKKVFLLGQTKQKIASELERIGYKNFEFVSTLKEAVRKSFECAQNGDIVLLSPACASWDMFENYEQRGRMFKEYVNELLTTGM
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_NITMU
Sequence: MELKLIDYNGQSSASVSASETLFGREYNEALVHQVVTAYLANARSANRAQKARSDVAKSTRKPWRQKGTGRARAGMASSPLWRGGGKIFPNSPEENFSHKVNRKMYRAGIGAILSQLVRENRLSVVENFIVDAPKTKILAQKLKDMGLDQVMIITDNIDENLYLSSRNLPLVKVVEAGYADPVSLMRFANVLITRNALAKMEEALA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RNPA_YERP3
Sequence: MVKLAFPRELRLLTPSHFTFVFQQPQRAGTPQITILGRLNELGHPRIGLTVAKKHVKRAHERNRIKRLTRESFRLHQHALPSMDFVVLVKKGVADLDNRALTEALEKLWRRHCRQAPAS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: MSRB_PSEAE
Sequence: MSKIDKPLDSWREELTEEQFHICRLGGTERAFSGEYHATKTPGIYHCTCCGTALFDSDAKYDSGSGWPSYFQPVDAEAVRELDDFSHGMHRIEVRCGRCDAHLGHVFPDGPRPTGLRYCINSASLKLVPRES
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: YBEY_WOLWR
Sequence: MLEVNILDKKWCSIIENPKNFVLGVINASLKELKIDHYKPNISIALADDDLLHQLNLKFREMDKPTNVLSFPYEQLSNECDLGDIAISIDTIKRESHEYYIPILAHIAHMLVHGLLHLLGYDHQKKDEEIIMKNLEREILASLGYNMCAI
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCP_STRMU
Sequence: MPIINKTMLITYADSLGKNLKELNENIENYFGDAVGGVHLLPFFPSTGDRGFAPIDYHEVDSAFGDWDDVKCLGEKYYLMFDFMINHISRQSKYYKDYQEKHEASAYKDLFLNWDKFWPKNRPTQEDVDLIYKRKDRAPKQEIQFADGSVEHLWNTFGEEQIDLDVTKEVTMDFIRSTIENLAANGCDLIRLDAFAYAVKKLDTNDFFVEPEIWTLLDKVRDIAAVSGAEILPEIHEHYTIQFKIADHDYYVYDFALPMVTLYSLYSSKVDRLAKWLKMSPMKQFTTLDTHDGIGVVDVKDILTDEEITYTSNELYKVGANVNRKYSTAEYNNLDIYQINSTYYSALGDDDQKYFLARLIQAFAPGIPQVYYVGFLAGKNDLELLESTKEGRNINRHYYSSEEIAKEVKRPVVKALLNLFTYRNQSAAFDLDGRIEVETPNEATIVIERQNKDGSHIAKAEINLQDMTYRVTENDQTISFE
What is the function of this protein?
Intracellular catabolism of sucrose (PubMed:2971020).  Being intracellular, probably not involved in synthesis of extracellular polysaccharides (Probable).
What are the official names of this protein?
Sucrose phosphorylase, Glucosyltransferase-A, GTF-A, Sucrose glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. Sucrose phosphorylase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_AGRFC
Sequence: MQWQDEAIILGVKRHGETSVIAEVMTPSRGRHLGMVRSGRSRTMQPVLQAGNRVDVIWRARLHDHLGEFRIEPLQLRAGQLMETATAVYGVQAMGALLRLLPERDPHPHLYQALDVILDNLHDPVDAGELFVRFELAVLNDLGFGLDLSECAATGLRSDLIYVSPKTGRAVCRTAGAPYAARMLALPAFLGEGQSKAADPESLAAAFRLTDHFLHRHVYDPRGLNENAARDGFVQAALKALERKAEPPALDKAV
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: SSRP_NEIMA
Sequence: MAIANNKKAFHDFFIEDRIEAGLVLEGWEVKAIRAARVQLKESYIYWKKDAFYLVGCHITALPTASTHIKPDAVRPRKLLLNQSEINKLIGKTERAGYTIVPLDLHFSRGKIKMEIGLAKGKKQHDKRQSMKEADWKREKQRLIKHTR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.