PharMolix/UniProtQA huggingface dataset:
Protein: PA_I80A8
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCKDISDLKQYDSDEPEPRSLASWIQSEFNKACELTDSSWIELDEIGEDIAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQVIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALK
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: ISPD_DEIRA
Sequence: MSAPHTSSPRTAALIPAAGSGTRLGLGPKAFVEVAGRSLLARSVAALAPFVDEVVVALPAGMDLPAGVPARAIVGGETRQGSVRRLLEATEAGTVLIHDAARPFVPPPVILALLDAIAATGAATVALPVADTLVRAEGQSWGQLVPREGLWAVQTPQGFRRELLLQAHARAEAEQYAATDDAGLLARLGVQVRLVPGDARLFKVTTPGDLALAEALTGHVDGGWLTVEGEKR
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: BADH2_ORYSI
Sequence: MATAIPQRQLFVAGEWRAPALGRRLPVVNPATESPIGEIPAGTAEDVDAAVAAAREALKRNRGRDWARAPGAVRAKYLRAIAAKIIERKSELARLETLDCGKPLDEAAWDMDDVAGCFEYFADLAESLDKRQNAPVSLPMENFKCYLRKEPIGVVGLITPWNYPLLMATWKVAPALAAGCTAVLKPSELASVTCLELADVCKEVGLPSGVLNIVTGLGSEAGAPLSSHPGVDKVAFTGSYETGKKIMASAAPMVKPVSLELGGKSPIVVFDDVDVEKAVEWTLFGCFWTNGQICSATSRLILHKKIAKEFQERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKQFVSTAKSQGATILTGGVRPKHLEKGFYIEPTIITDVDTSMQIWREEVFGPVLCVKEFSTEEEAIELANDTHYGLAGAVLSGDRERCQRLTEEIDAGIIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSVKQVTEYASDEPWGWYKSPSKL
What is the function of this protein?
Dehydrogenase that can use N-acetyl-c-aminobutyraldehyde (NAGABald), gamma-guanidinobutyraldehyde (GGBald), betaine aldehyde (Bet-ald), gamma-aminobutyraldehyde (GAB-ald), acetaldehyde, 4-aminobutylaldehyde (AB-ald), 3-aminopropionaldehyde (AP-ald), 4-N-trimethylaminobutyraldehyde (TMAB-ald) and 3-N-trimethylaminopropionaldehyde (TMAP-ald) as substrates.  Catalyzes the oxidation of GAB-ald more efficiently than Bet-ald.  Mediates the conversion of GAB-ald into gamma-aminobutyric acid (GABA), and prevents the formation of 2-acetyl-1-pyrroline (2AP) which gives fragrant rice its aromatic properties.
What are the official names of this protein?
Betaine aldehyde dehydrogenase 2, BADH 2.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Peroxisome. Cytoplasm.
Protein: PSBE_CYACA
Sequence: MSGGSTGERPFSDIITSVRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGTPRPNEYFSENRQQVPLINDRFNAREELDDLTSNL
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SODF_CAMJJ
Sequence: MFELRKLPYDTNAFGDFLSAETFSYHHGKHHNTYVTNLNNLIKDTEFAGKDLVSIIKTSNGGVFNNAAQVYNHDFYFDCIKPSTGCGCGGSCQSIDANLQAALEKEFGSLENFKAEFIKGATGVFGSGWFWLVYNTKNQKLEFVGTSNAATPITEDKVPLLVVDVWEHAYYVDHRNARPAYLEKFYAHINWEFVAKAYEWALKEGMGSVSFYANELHPVK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Fe].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: HAL2_HALST
Sequence: GKWMSLLKHILK
What is the function of this protein?
Short linear cationic amphipathic alpha-helical antimicrobial peptide (AMP) with potent activity against both Gram-positive and Gram-negative bacteria, moderate activity against the yeasts C. albicans, S. cerevisiae, C. glabrata, C. krusei, and C. tropicalis, and low activity against the yeasts C. dubliniensis and C. parapsilosis (PubMed:20198492, Ref. 2, PubMed:28600071).  Minimum inhibitory concentrations (MIC) have been tested on B. subtilis (MIC=1. 0 uM), S. aureus (MIC=11. 1 uM), E. coli (MIC=2. 6 uM), P. aeruginosa (MIC=15. 8 uM), and the yeast C. albicans (MIC=6. 6 uM) (PubMed:20198492, Ref. 2).  Also shows noticeable hemolytic activity (LC(50)=91 uM on human erythrocytes, and 78. 1 uM on rat cells), indicating it cannot be considered for therapeutic application (PubMed:20198492).  Interacts more strongly with anionic membranes compared to the zwitterionic ones because of the electrostatic contribution (PubMed:32336099).  Interaction with anionic membranes is accompanied by structuring of the peptide as an alpha-helix and deep insertion into the membrane causing substantial membrane permeabilization at very low peptide/lipid molar ratios (PubMed:32336099).  In the context of inflammation and cancer tests, is weakly cytotoxic to normal cells, induces calcium signaling but does not impact cAMP production (PubMed:22100226, PubMed:36548715).  In addition, prevents LPS-induced nitric oxid (NO) synthesis but does not affect the IP3 signaling and pro-inflammatory activation of endothelial cells (PubMed:36548715).  Is cytotoxic towards cancer cells (HeLa S3 (IC(50)=12 uM), CRC SW 480 (IC(50)=35 uM) and CCRF-CEM T (IC(50)=34 uM)), but does not show significant antiproliferative activity on the breast cancer cell line MDA-MB-231 (PubMed:22100226, PubMed:36548715).
What are the official names of this protein?
Halictine-2, HAL-2, Halictin 2, Halictine II.
What is the protein family that this protein belongs to?
Belongs to the lasioglossin-like family.
Protein: PORD_METBF
Sequence: MKNEGEKEGLNISRCRVCKPGSTLINKTGGWRNFRPVYIYEKCTKCGICHIVCPDMSVKPRENGFFEYDYDYCKGCGICANECPADAIEMILEEK
What are the official names of this protein?
Pyruvate synthase subunit PorD, Pyruvate oxidoreductase delta chain, POR, Pyruvic-ferredoxin oxidoreductase subunit delta.
Protein: RIMO_ECO81
Sequence: MSKVTPQPKIGFVSLGCPKNLVDSERILTELRTEGYDVVPSYDDADMVIVNTCGFIDSAVQESLEAIGEALNENGKVIVTGCLGAKEDQIREVHPKVLEITGPHSYEQVLEHVHHYVPKPKHNPFLSLVPEQGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPIGEVLSEAKRLVDAGVKEILVISQDTSAYGVDVKHRTGFHNGEPVKTSMVSLCEQLSKLGIWTRLHYVYPYPHVDDVIPLMAEGKILPYLDIPLQHASPRILKLMKRPGSVDRQLARIKQWRKICPELTLRSTFIVGFPGETEEDFQMLLDFLKEARLDRVGCFKYSPVEGADANALPDQVPEEVKEERWNRFMQLQQQISAERLQEKVGREILVIIDEVDEEGAIGRSMADAPEIDGAVYLNGETNVKPGDILRVKVEHADEYDLWGSRV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_MYCPU
Sequence: MRQTTIVKHKEVNKKWFLIDADGVVLGKLATLTASILRGKNKPDFTPNVDMGDNIVIINAEKVVLTANKEEDKKYYSHSGYPGGLKVINAAKLRAKKPIAIVEKAVKGMLPHTKLGRQQFRNLYVYAGSVHKQEAQQPVRIEVK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: JANA_DROER
Sequence: MNRFQLLSKGLRLIHKMSEEALAGVPLVHISPEGIFKYVMINVIDGGDASKAVIRGFADCTWHADIFDREEEVFKKLGLRAECPGGGRIEHNPDKKYLKVYGYSQGFGKADHAQTKRILATKYPDYTIETSDEGY
What is the function of this protein?
JanA and janB regulate somatic sex differentiation.
What are the official names of this protein?
Sex-regulated protein janus-A.
What is the protein family that this protein belongs to?
Belongs to the janus family.
Protein: DNAG_METMP
Sequence: MDLGTTKYIIYTELIADGYVEKHDVIGAIFGQTEGLLSNELDLRDLQKSGRIGRIDVELENINGKSFAKITLPSSLDKVETSILAATLETIDRVGPCFATVKITEVEDIRVSKRQYITNRARSILRKLMDEMIDTYEITEEIKESLRTEEIMEYGPENLPCGPNIIHSDSIIVVEGRADVLNLLRCGIKNTVAVEGTSVPKSIMELTKKKTTTAFTDGDRGGELILKELLQTCDIDYVARAPYGKEVEGTSKKELMKCLRAKVPVEQIVGNNCNGSGVIESNTPKEIVEPITPKHFEKVETPAVIEPVFKEDAIEEETIIVEPVKKAETEIIDVDATNETQSEKKFSGVKEIVDSIKNTGNVKFVVDGTEKTNTFKEFLTNIHEIKKMDFFAADMPISQKIVDLLYDKTPIIVGKEINVTKKPVNLRLFSFDEIVA
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: TUSA_SHIF8
Sequence: MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPGFCTFMEHELVAKETDGLPYRYLIRKGG
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_BRUC2
Sequence: MMESGEALLKKLDGRLSGLRGRLTPDTGMDKITWFRAGGPAQVLFQPSDEEDLSAFLKAVPEEIPLLVVGIGSNLLVRDGGVPGFVVRLSAKGFGEVEQVCDTQLRAGAAAPDKRVAAAALEAGLADFHFYHGIPGGIGGALRMNAGANGVETRERVVEVRALDRKGEVHVLSNADMGYAYRHSSASPDLIFTSVLFEGVPGERDDIRRAMDEVQHHRETVQPVREKTGGSTFKNPEGTSAWKEIDKAGCRGLRVGGAQMSEMHCNFMINTGNATGHDLETLGETVRARVFENSGIRLHWEIKRLGLFREGEQIEEFLGKII
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_LEPBP
Sequence: MAAKKVVKQIKLQVEAGKANPAPPVGPALGQAGLNIMEFCKQFNERSKNQMGLKLPVVITVYSDRSFTFVTKSPPAALLVMKALGLQGGSATPHTVKVGTIKRAQLEEIAKTKMEDLNANDMDAAVKIIAGTCRSMGVNVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: IBBD2_SOYBN
Sequence: MCILSFLKSDQSSSYDDDEYSKPCCDLCMCTRSMPPQCSCEDIRLNSCHSDCKSCMCTRSQPGQCRCLDTNDFCYKPCKSRDD
What are the official names of this protein?
Bowman-Birk type proteinase inhibitor D-II, IV.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: TSAD_BIFAA
Sequence: MSEPIVLGIESTCDETAAAVVQGRTLISNVVASSMDEHARYGGVIPEIASRAHAEAFVPCVSKALADANMTLSDVDAIAVSAGPGLAGCLAVGVSGAKSLAWAANKPIYGINHVIGHIAVTQLQFGPFPKDTLALIVSGGHTSLLHVEDVARHIDVVGTTLDDAAGECFDKVARLLGFPYPGGPHIDRHAQLGNPHAIKVPQGLTQGKAGQQHPYDFSFSGVKTAVARWIEQQQAEGNEIPIDDVCASLADSVATVLARKAMRGCEQYGSKTLIVGGGFSANSQLRAKLLEVGAKHGVEVRIPQIKLCTDNGAMVAMLGVNLVESGVKPSEPDFAIDSAMPLTKISM
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_CHLCV
Sequence: MEKKILEYLKRLEEVEVKISNPEIFENPKEYSSLSKEHARLSELKNVYDKVLGQEKILNDDKEALAQEKDPEMIAMLEEGIQLGKAEVDKLYKVLENLLVPPDPDDDLNVIMELRAGTGGDEAALFVGDCVRMYHLYASTKGWKYEVLSASESDIGGYKEYVMGISGAAVKRLLQYEAGTHRVQRVPETETQGRVHTSAITVAVLPEPAEDDEEVFIDEKDLKIDTFRASGAGGQHVNVTDSAVRITHLPTGVVVTCQDERSQHKNKAKAMRILKARIRDAEMQRRQKEASAMRSAQVGSGDRSERIRTYNFSQNRVTDHRIGLTLYNLDKVMEGDLDAITSALVSHAYHQLLQHGNEENS
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAM1_MEDTR
Sequence: MINSLCGSSNSLKEKCLQPNSSNQTNTHSKKNATNSCGDLEQINVLTPQSLNLPSLKFDLDGDVEVQSPDSSMWEAFFNDHLDNDFMISSPIRNINPNSPQASTYNNCNYNYAQGMQIQSLSGCSPPRFASQIGSLNSNNQQKGKGLSPLHRVFNSPNNQYMQHVENLSLPAIEEFLEDFQGDVDHFSSTKVSSECFDMETPISTILDSLTMQNSSSYGASVNEESTLLHGGNSSSQISQESDIYHQMGSMASASLSQALQQERYQEKHQKMQAQQQSLTVPIQIGIEQEQDSGLQLVHLLLACAEAVAKGEYMLARRYLHQLNRVVTPLGDSMQRVASCFTESLSARLAATLTTKSSSTKKLAPSSLSSSSSSSCLSTFPSNPMEVLKIYQIVYQACPYIKFAHFTANQAIFEAFEAEERVHVIDLDILQGYQWPAFMQALAARPGGAPFLRITGVGPCIESVRETGRCLTELAHSLRIPFEFHPVGEQLEDLKPHMFNRRVGEALAVNTVNRLHRVPGNHLGNLLSMIRDQAPNIVTLVEQEASHNGPYFLGRFLEALHYYSAIFDSLDATFPVESAPRAKVEQYIFAPEIRNIVACEGEERIERHERLEKWRKIMEGKGFKGVPLSPNAVTQSRILLGLYSCDGYRLTEDKGCLLLGWQDRAIIAASAWRC
What is the function of this protein?
Transcription factor acting as a central regulator of arbuscular mycorrhiza (AM)-related genes (e. g.  AMT2;4, AMT2;5, EXO70I, STR, RAM2, LEC5, PT4, VPY, BCP1, SCP1 and RAD1) required for the morphogenesis of arbuscules upon symbiosis with AM fungi (e. g.  Rhizophagus irregularis and Glomus versiforme) (PubMed:25971550, PubMed:26511916, PubMed:23122845).  Promotes directly the expression of RAM2, EXO70I, STR and RAD1 (PubMed:26511916).  Not necessary to enable hyphopodium formation or hyphal entry into the root but essential to support arbuscule branching (PubMed:26511916).  Involved in the phosphate-mediated suppression of AM fungi colonization in mycorrhiza (PubMed:26511916).  Also involved in restricting mycorrhizal colonization of the root meristem (By similarity).  Required for Myc factor signaling from mycorrhizal fungi, but has no function in Nod factor signaling from rhizobial bacteria (PubMed:23122845).  Regulates the expression of RAM2, a glycerol-3-phosphate acyl transferase that promotes cutin biosynthesis to enhance mycorrhizal hyphopodia formation (PubMed:23122845).
What are the official names of this protein?
GRAS family protein RAM1, Protein REQUIRED FOR ARBUSCULAR MYCORRHIZATION 1, MtRAM1.
What is the protein family that this protein belongs to?
Belongs to the GRAS family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: NUOA_SALCH
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARHKNVPFESGIDSVGTARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLARIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NS48_CVBLU
Sequence: MPMATTIEGADYTNIMPITVLTTVYLGVSIGIDTSTTGFTCFSRY
What are the official names of this protein?
Non-structural protein of 4.8 kDa, ns4.8, 4.8 kDa accessory protein.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses ns4/ns4.8 protein family.
Protein: CBPA2_HUMAN
Sequence: MAMRLILFFGALFGHIYCLETFVGDQVLEIVPSNEEQIKNLLQLEAQEHLQLDFWKSPTTPGETAHVRVPFVNVQAVKVFLESQGIAYSIMIEDVQVLLDKENEEMLFNRRRERSGNFNFGAYHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPMNVLKFSTGGDKPAIWLDAGIHAREWVTQATALWTANKIVSDYGKDPSITSILDALDIFLLPVTNPDGYVFSQTKNRMWRKTRSKVSGSLCVGVDPNRNWDAGFGGPGASSNPCSDSYHGPSANSEVEVKSIVDFIKSHGKVKAFITLHSYSQLLMFPYGYKCTKLDDFDELSEVAQKAAQSLRSLHGTKYKVGPICSVIYQASGGSIDWSYDYGIKYSFAFELRDTGRYGFLLPARQILPTAEETWLGLKAIMEHVRDHPY
What are the official names of this protein?
Carboxypeptidase A2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PROF_VAR67
Sequence: MAEWHKIIEDISKNNNFEDAAIVDYKTTKNVLAAIPNRTFAKINPGEVIPLITNHNILKPLIGQKFCIVYTNSLMDENTYAMELLTGYAPVSPIVIARTHTALIFLMGKPTTSRRDVYRTCRDHATRVRATGN
What is the function of this protein?
Participates in either intracellular transport of viral proteins or intercellular spread of the virus.  Cellular profilins modulate actin filament dynamics (polymerization and depolymerization) via direct binding to actin through an actin-binding domain as well as by modulation of other actin-binding proteins.  In contrast to cellular homologs, the poxvirus profilins seem to bind actin only weakly (By similarity).
What are the official names of this protein?
Profilin.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Localizes to inclusion bodies formed by viral A25/ATI protein in the cytoplasm of the host cell.
Protein: ILVD_SULSY
Sequence: MRSDEIKKGIERAPHRSLLRACGLKEEDFGKPFIGIANSYIDIIPGHVHLQEFAKIVKEAIREAGGVPFEFNVIGVDDGIAMGHSGMFYSLPSRELIADSVETVVQAHKLDGLVLIPNCDKIVPGMIMAAARVNIPTILVSGGPMAAGHTSDGKPIDLATVFEAVGGIKKGLIDEKQLIDIETHACPTCGSCSGMFTANSMNCLAEALGIALPGNGSILAIDPRRKELAKQAGRQIVELVKAGLKFRDIVNQETIENAFTLDIAMGGSSNTVLHLLAISHEAGIEFPMEKIDEISRKTPTLCKLAPASQYHMEDLDKAGGIYAILKELSKKNLLHLDRPTVLMKTIGEAIKDAEIKDTNVIRPLENPYNETGGLAVLFGNLAPDGAVVKAAAVDPKILVHRGTAVVFDSEEEAIEGITNGKVKEGNVVVIRYEGPKGGPGMREMLAPTSTIMGMGLGDKVSLITDGRFSGATRGACIGHVSPEAAAGGPIGIVQNGDEILIDIPNRKIELLISEQEFERRMKEFKPKKKEIPSPWLRRYSKFVTSANKGAILSDECS
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: IBP1_ICTTR
Sequence: MPEVPAAGLWPFLLLLAVQVSTVASSTQPWHCAPCSAEKLALCPPVPSSCPELSRPAGCGCCPMCALPLGAACGVATARYARGLSCRALPGEPRPLHALTRGQGACVPEPATPTASGLSSIEKEEAKASMVPERVPPESAEMTEEQLLESFHLMASSSEDQPILWNAISTYKSMRAREMADIKKWKQPCRRELYKVLERLAKAQQKAGEEIYKFYLPNCNKNGFYHSKQCETSLDGEAELCWCVYPWSGRRIPGSLEIRGDPNCHQYFNVQN
What is the function of this protein?
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.  Promotes cell migration (By similarity).
What are the official names of this protein?
Insulin-like growth factor-binding protein 1, IBP-1, IGF-binding protein 1, IGFBP-1.
What are the subcellular locations of this protein?
Secreted.
Protein: CT52_CONCB
Sequence: MRCVPVFLILLGLIASAPSVDARPQTKDDALASFHDSAKRHLQRLVNARKCCPESPPCCHYFGRRK
What are the official names of this protein?
Conotoxin Ca5.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS12_ECO5E
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PLSY_BRUSI
Sequence: MAEPGFFNAMLIGALIFGYVLGSIPFGLILARLAGLGDVRAIGSGNIGATNVLRTGNKKLAAATLILDALKGTAAALIAAHFGQNAAIAAGFGAFIGHLFPVWIGFKGGKGVATYLGVLIGLAWAGALVFAAAWIVTALLTRYSSLSALVASLVVPIALYSRGNQALAALFAIMTVIVFIKHRANISRLLNGTESKIGAKG
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.