PharMolix/UniProtQA huggingface dataset:
Protein: CLCKB_XENLA
Sequence: MSRVLVIEQREGEEKTLIQKHIFRPFPNTRRVVIDHLQRLKNFLFRIGDDWYFLFALGVIMALISFTMDFTVSKMLNAHRWLQQELGGNVLLRYLSWIVYPIALVAFSTGFAQSITPHSGGSGIPELKTILSGVILEEYLTIKNFGAKVVGLTCTLSAGSTMFLGKVGPFVHLSSMIAAYLGRMRTSVAGDYENKSKEHEMLVAAAAVGVSTVFGAPISGVLFSVEVMSSHFAIRNYWRGFFAATCGAFVFRLLAVFNSEQETITAVFKTSFKISFPFDLPEMFFFAILGVVCGLIGCAYLFCQRWLLGYVRRNSLTSKLLASDKPMYSALVALLISSITFPESLGQFLASRLTMKELLTSLFDNRTWWISLSQNSSLDRSPLVDPNNLWLEWANPQFTIFGTLAFFIIMKFWMFILATTLPMPAGYFMPVFVFGAAIGRLVGETVALLYPEGIAADGIVNPIIPGGYAWQGAPAYSGAVTHSVSTALLAFEATGQIAHILPVILCVLIANAFTQKLQPSFYDGTIIVKKLPYLPRIRSRDIDSYKVNTEEFMNPDIRVLPREAGFEDVLKVITASDDSEYPVVDNTESQVLVGTVKRPQLIHFLETHESHERAGPTEKENLSEGNLGEACSIEPVTFQLSTWTSLHQAHHLFELLHLQKAFVTKYGRIVGQVTRKEMKKAIEDLANPK
What is the function of this protein?
Voltage-gated chloride channel.  Chloride channels have several functions including the regulation of cell volume, the stabilization of membrane potential, signal transduction and transepithelial transport.
What are the official names of this protein?
Chloride channel protein ClC-Kb, Chloride channel Kb, x6clck, xCIC-K.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
Protein: VEL1_YEAST
Sequence: MSFLSIFTFFSVLISVATTVRFDLTNVTCKGLHGPHCGTYVMEVVGQNGTFLGQSTFVGADVLTESAGDAWARYLGQETRFLPKLTTIASNETKNFSPLIFTTNINTCNPQSIGDAMVPFANTVTGEIEYNSWADTADNASFITGLANQLFNSTDYGVQVASCYPNFASVILSTPAVNIFGKDDTLPDYCTAIQLKAVCPPEAGFD
What are the official names of this protein?
Protein VEL1, Velum formation protein 1.
What is the protein family that this protein belongs to?
Belongs to the VEL1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Note=Intracellular soluble fraction.
Protein: RS21_THEP3
Sequence: MAEVRVGENESLDNALRRFRRQCSKAGVLSEVRKREHYESPSVKRKKKSEAARKRKYKYNK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: 5HT1D_RAT
Sequence: MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various alkaloids and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling inhibits adenylate cyclase activity.  Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity.  May also play a role in regulating the release of other neurotransmitters.  May play a role in vasoconstriction.
What are the official names of this protein?
5-hydroxytryptamine receptor 1D, 5-HT-1D, 5-HT1D, Serotonin receptor 1D.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IL13_BOVIN
Sequence: MALLLTAVIVLICFGGLTSPSPVPSATALKELIEELVNITQNQKVPLCNGSMVWSLNLTSSMYCAALDSLISISNCSVIQRTKRMLNALCPHKPSAKQVSSEYVRDTKIEVAQFLKDLLRHSRIVFRNERFN
What is the function of this protein?
Cytokine that plays important roles in allergic inflammation and immune response to parasite infection.  Synergizes with IL2 in regulating interferon-gamma synthesis.  Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity).  Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity).  Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity).  Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils.  Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6.  Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity).
What are the official names of this protein?
Interleukin-13, IL-13.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL34_ACET2
Sequence: MLRTYQPKKRQRKKEHGFRKRMKTANGRKVLRRRRLKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: Y8213_DICDI
Sequence: MNILSFIVYYNGEINRIYFNMGQKNSFPMKVSTIEFLNRLSNEPILEISNETTNILKLSINSLESNNNLIDLSKLTLNSIITLN
What are the official names of this protein?
Putative uncharacterized protein DDB_G0280023.
Protein: RL32_STRE4
Sequence: MAVPARHTSKAKKNKRRTHYKLTAPSVKFDETTGDYSRSHRVSLKGYYKGHKIAKANAAE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RL20_NITHX
Sequence: MARVKRGVTAHAKHKKVYKITKGFSGRRKNTIRAAKAAADKAGQYAFRDRKRKKRTFRALWIQRLNAAVRPFGMTYSVFINGLSKSGITVDRKVLSDLAINEPAAFQAIAEKAKAALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: HEM2_METTH
Sequence: MSDNMEFPTKRMRRLRKSPQIRNILRETRLHPSDLIYPMFVSEKLGRGDVEAIDTMPGQFRYSVDDAVSEASRLEDEGLSSVLIFGMPSAKDELASAAHDPHGVVQRTVRRLKEETDLVVMTDVCLCQYTSHGHCGIVVDGEIVNDETLEVLSRIALSHAEAGADVVAPSDMMDGRVAAIRRSLDDAGFQDTLIMSYAVKYASAFYAPFRGAVSSAPAFGDRRSYQMDPANIDEALIEAELDLREGADILMVKPALAYLDVIGKVRERFSVPLAAYNVSGEYSMLKAAIKSGYLTDEAIYESILSIKRAGADLIISHFAPDLLGVI
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: 5HT1E_CAVPO
Sequence: MNITNCTTDASMVVRPKTVTEKMLICMTLVIITTLTMLLNSAVIMAICTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIMYIVMDSWRLGYFICEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAGLMILTVWTISIFISMPPLFWRSHRQLSPPPSQCTIQHDHVIYTIYSTFGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKIHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVGDFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various alkaloids and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling inhibits adenylate cyclase activity.
What are the official names of this protein?
5-hydroxytryptamine receptor 1E, 5-HT-1E, 5-HT1E, Serotonin receptor 1E.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBT5_CANAL
Sequence: MLALSLLSIVSIASAAGVTAIPEGDNPYTIFPSVAKTASINGFADRIYDQLPECAKECVKQSTSSTPCPYWDTGCLCVMPQFAGAVGNCVAKNCKGKEVGSVESLATSICSSAGVWEPYWMIPSSVSDALAKAADAAAETTAESTTAESTAAETTKAEETSAKETTAAETSKAAESSAPAETSKAEETSKAAETTKAEESSVAQSSSSAADVASVSVEAANAGNMPAVAIGGVIAAVAALF
What is the function of this protein?
GPI-linked hyphal surface heme-binding protein involved in heme-iron utilization (PubMed:15306022, PubMed:17042757, PubMed:18466294, PubMed:21205162, PubMed:25275454, PubMed:27617569).  Heme transfer occurs between PGA7, RBT5 and CSA2 supporting a model in which the 3 CFEM proteins cooperate in a heme-acquisition system and form a cross-cell wall heme-transfer cascade (PubMed:15306022, PubMed:17042757, PubMed:18466294, PubMed:21205162, PubMed:25275454, PubMed:27617569).  The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms.  Required for biofilm formation (PubMed:15306022, PubMed:17042757, PubMed:18466294, PubMed:21205162, PubMed:25275454).
What are the official names of this protein?
GPI-anchored hemophore RBT5, Repressed by TUP1 protein 5.
What is the protein family that this protein belongs to?
Belongs to the RBT5 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell membrane; Lipid-anchor, GPI-anchor. Note=Found anchored in the cell membrane as well as a covalently-linked GPI- modified cell wall protein (GPI-CWP).
Protein: ACTN2_HUMAN
Sequence: MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL
What is the function of this protein?
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures.  This is a bundling protein.
What are the official names of this protein?
Alpha-actinin-2, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein.
What is the protein family that this protein belongs to?
Belongs to the alpha-actinin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
Protein: H6ST1_HUMAN
Sequence: MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTPDPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYNSTRAGGVEVDEDTIRRIEELNDLDMQLYDYAKDLFQQRYQYKRQLERREQRLRSREERLLHRAKEALPREDADEPGRVPTEDYMSHIIEKW
What is the function of this protein?
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.  Critical for normal neuronal development where it may play a role in neuron branching.  May also play a role in limb development.  May prefer iduronic acid.
What are the official names of this protein?
Heparan-sulfate 6-O-sulfotransferase 1, HS6ST-1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 6 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: EIF2A_DANRE
Sequence: MAPPTPHLAVRGSDGTLLLHGPPNCQESSAFQRDDRQGRYMTFSNDGTLFAWCNGSQVTVLKVPSGDLVKSFDLPKTTALEFSPLNKVLATWQQYTKTQDNPQGEANLQLWDLQTGACMKAFYQKKMTGWCPSWADDESISVRNVNNELHFFENNNFETIANKLHLQKVSEFALSPGSQPSKVAVYVPGSKGAPSFVRLYQYPNFGGPTCALANKSFFKADKVNMLWNKKATAVLVTASTEVDKTGASYYGEQTLHYVATNGESAVVQLPKNGPIYDVSWSPNSTEFCVVYGFMPAKATVFNNKCESVFDFGTGPRNAAFYSPQGHILVLAGFGNLRGQMEVWDVKKYKQVSKPQAEDTTHFSWCPDGEHIVTATCSPRLRASNGYKIWHYTGTVLYKHETPSGKELWEVLWQPFPAGVFPERAVKYQALPSELGSTEAKPAQAYRPPALRNKPQTASSKLHEEEPPQNMKPGAAGEKQPSKAALKNQKRREAKKAAKQENKPDEAPPPAADPAPVSHVTSSCGDPETDKKIKNLKKKLKAIDELKEQQAAGKVMQKNQLEKMQKEAQLLKELEDLELGL
What is the function of this protein?
Functions in the early steps of protein synthesis of a small number of specific mRNAs.  Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits.  In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
What are the official names of this protein?
Eukaryotic translation initiation factor 2A, eIF-2A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EIF2A family.
Protein: IAA5_ORYSJ
Sequence: MSPPLEPHDYIGLSAAAASPTPSSSSCSSSPNPGGEARGPRLTLRLGLPGSESPEREVVAAGLTLGPLPPTTTKAASKRAFPDSSPRHGASSGSVAAAAACQDKAAPAAAPPAAKAQVVGWPPVRNYRKNTLAASASKGKGEDKGTAEGGPLYVKVSMDGAPYLRKVDLKMYSSYEDLSMALEKMFSCFITGQSGLRKSSNRDRLTNGSKADALQDQEYVLTYEDKDADWMLVGDLPWDLFTTICRKLKIMRGSDAAGIAPRSIEQSGQSR
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.
What are the official names of this protein?
Auxin-responsive protein IAA5, Indoleacetic acid-induced protein 5.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: THI4_SULAC
Sequence: MSDSIKIKAIDEVKISRYIIKQTMEDWMNFVENDVVIVGAGPAGMSAAYYLAKHGLKTLVFERRLSFGGGIGGGAMLFHKLVIESPADEVLKEMNIRLEKVEDGVYIVDSAEFMAKLAASAIDAGAKIIHGVTVDDVIFRENPLRVAGVAVEWTATQMAGLHVDPVFISAKAVVDATGHDAEVVAVASRKIPELGIVIPGERSAYSEMAEKLTVEQTGVVAPGLYVAGMSVTEVRGLPRMGPIFGSMVLSGKKVAEDIIKDLRNS
What is the function of this protein?
Involved in the biosynthesis of the thiazole moiety of thiamine.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
What are the official names of this protein?
Thiamine thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
Protein: HIS7_SYNE7
Sequence: MQLSDRPLTAPGTAPRQATVSRRTGETDVQVFLNLDGTGRCQADTGIPFLDHMFDQIASHGLIDLEITAKGDLHIDDHHTNEDVGITFGLALAEALGDRKGIVRFGHFVAPLDEALVQVALDFSGRPHLTYGLTLPTERVGTYETQLVREFFVAIANNAKLTLHLRQLDGINSHHIIEATFKAFARSLRMATEVDPRRAGQIPSSKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_CHLP8
Sequence: MKRDYYEILGVSRSADKDEIKKAYRKLALKYHPDKNPDNKEAEEKFKEANEAYEVLSNDDKRRRYDQFGHAGVGSSAASGGGPGGFGGGGYADINDIFEMFTGGGRARGGGSPFSGFEDIFGGGFSGGGGRRARSTGIHGTDLKIRLKLTLEEIAKGVEKTLKIKKQVVCSECNGTGSKSGKTETCQTCHGSGEVRQASKTMFGQFVNIVACPTCGGEGQVVKDRCTSCYGEGIKQGEVTVKINVPAGVQDGNYLTLQGQGNAGPRGGAPGDLIVIIEEKPHDQFKRNGDDIIYDLAVGFPDLVLGTKVDVPTLDGHVKLTVPAGTQPNTMLRIGGKGIGHLKGGGSGDLYVRVNVFVPKDVSGKDKEMLKELKKSSHISPNHGEQDHEKSIFEKAKDIFG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSC_YERPN
Sequence: MARKRIAFIFTQGPHGSSAGREGLDALLATSALSEDIGVFFISDGVLQLLPQQQPEKILARNYIATFGVLPLYDVENCYLCERSLQQRGLSKMADWILDVTVLSPADLRRELGTYDVVLTF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_CHLTE
Sequence: MNYEIVVGLEVHCQLNTESKAFCGCSAKFGKPANTNVCPVCLALPGALPVLNARVVEDAVKLGLATNCTIARHSILARKNYFYPDLPKGYQISQYEEPICSEGVIHIDLEEGGKDVRLVRIHIEEDAGKSIHDIGDDTYIDVNRCGVPLLEIVSYPDMRTPKEASAYLQKLRQIVRYLGISDGNMEEGSLRCDANVSVRPVGATEYGTRTEIKNMNSFRNVERAIEYEAKRHIEVIEGGGTIVQETRLWDADKLETRSMRGKEHAHDYRYFPDPDLVPVLVDDGMIRRMQEELPEFPEDRAARFVSEFGIPAYDAGVITVDRELADYFESTVKVSGDAKASSNWVMGEVMRTLKEKYLDIHKFAISPERLGGLIKLINAGAISNTIAKQVFEIMQQDEATAEAIVEREGLAQVSDRGAIEAAIREILEANQKQLEQYRSGKTQLFGFFVGQCMQKMKGKANPKMVNDILRSMLDA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: EMP2_PANTR
Sequence: MLVLLAFIIAFHITSAALLFIATIDNAWWVGDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHHKNAKFYPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK
What is the function of this protein?
Functions as a key regulator of cell membrane composition by regulating protein surface expression.  Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.  Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity).  Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (By similarity).  Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins (By similarity).  Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity).  Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (By similarity).  Also regulates many processes through PTK2 (By similarity).  Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (By similarity).  Regulates cell migration and cell contraction through PTK2 and SRC activation.  Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (By similarity).  Positively regulates cell proliferation (By similarity).  Plays a role during cell death and cell blebbing (By similarity).  Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (By similarity).  Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (By similarity).  Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity).  Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity).  May play a role in glomerular filtration (By similarity).
What are the official names of this protein?
Epithelial membrane protein 2, EMP-2.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane. Apical cell membrane. Membrane raft. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane on plasma membrane.
Protein: DXS_FRATM
Sequence: MSKYTILDKINTPSDLKLIPESQLKILSAELRAFLVDTLDVSGGHFASSLGATELTVALHYVYNAPDDNIVWDVGHQTYIHKILTGRKDKLVTIKKDGGISGFPKRSESEYDTFGVGHSSTSISAALGMAIADRLQGKSSNTVAVIGDGAITGGMAFEALNHAGGIKEDILVILNDNEMSISDNVGGLSAHFSKIISGGFYNSIREKGKEVLKNIPPIFEFVKKVETQTKGMFVPANFFEDLGFYYVGPIDGHDVTELVKTLRILKDHKGPKLLHVITKKGKGYTKAESDPIKFHHVAPSFHSGENITTKISKPTYSNIFGDWICQKAAKDKRLVGITPAMKEGSDLIRFSQLYPHRYFDVAIAEQHAVTFAGGLACQGLKPVVAIYSTFLQRAYDQVIHDIALQNLDVLYAVDRAGLVGADGATHDGSFDLAFMRCIPNHVIMTPSDENEAYHMLEFGYEYNGPAMVRYPRGAGIGAEITGSLDLELGKAKIVKQGSKIAILNFGTLLPLAKQLAEKYHATVIDMRFVKPLDEIMLDKVSQTYEIILTLEENCIAGGAGSAVNEYFVAKDLSNKIIVRNFGLQDKFLNHGTKDLLLAQSKLCVENISQELDKLI
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RLMN_SHEHH
Sequence: MSEKKINLLDLDRKALRVLFTEMGEKPFRADQLMKWIYHFGVSDFEEMTNINKVLRAKLAAKCEIVAPEISSYQKSVDGTIKFAINVGDGQEVETVYIPEDDRATLCVSSQVGCALECTFCSTAQQGFNRNLTVAEIVGQIWRVADFIGFVKDTGERPITNVVMMGMGEPLLNLKNVIPAMDIMLDDFGFSLSKRRVTLSTSGVVPALDKLGDALDVALAVSIHAPNDELRDVLVPVNKKYPLEEFLGGIRRYIAKSNANRGRVTVEYVMLDHINDSTDQAHELAKLMKDTPCKVNLIPFNPYPGSPYGRSSNSRIDRFSKVLMEYGLTVIVRKTRGDDIDAACGQLAGDIRDRTKRLAKKQMQESQISVTMN
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.