PharMolix/UniProtQA huggingface dataset:
Protein: PDE1_YEAST
Sequence: MVVFEITILGANGGPTEYGTQCFILKPARTEDPELIAVDGGAGMYQLREMLVQGRNENEGDDELVPSFYEHDREPIEFFIDSKLNIQKGLSKSLLQSLKRQGEHFESANTMKKTYEVFQGITDYYITHPHLDHISGLVVNSPSIYEQENSKKKTIWGLPHTIDVLQKHVFNDLIWPDLTAERSRKLKLKCLNPKEVQKCTIFPWDVIPFKVHHGIGVKTGAPVYSTFYIFRDRKSKDCIIVCGDVEQDRRESEESLLEEFWSYVAENIPLVHLKGILVECSCPLSSKPEQLYGHLSPIYLINELSNLNTLYNSSKGLSGLNVIVTHVKSTPAKRDPRLTILEELRFLAEERNLGDLRISIALEGHTLFL
What is the function of this protein?
Controls the level of cAMP in yeast cells, together with the high-affinity cAMP phosphodiesterase (PDE2).
What are the official names of this protein?
3',5'-cyclic-nucleotide phosphodiesterase 1, PDEase 1, 3':5'-CNP, Low-affinity cAMP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase class-II family.
Protein: PB2_I43A0
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPMTSTVHYPKIYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGKDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMIGILPDMTPSTEVSMRGVRVSKMGVDEYSNAERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGTLTEDPDEGTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: ENO_KINRD
Sequence: MATIEAVGAREILDSRGNPTVEVEVLLDDGTFARAAVPSGASTGAYEANERRDGDKGRYGGKGVEQAVEAVIEEVGPALVGHDAHEQRIIDRVMLDLDGTPTKSRLGANAILGVSLAVAKAAASAADLPLFRYLGGPNAHVLPVPMMNIVNGGAHADTGVAIQEFMIAPVGAASFREALRWGAETYHALKSVLKQRGLATGLGDEGGFAPDLPSNKDALDLIVEAIGKTGFAVGSDIALALDVAATEFHGADGYDFEGSKRSAEWMTGYYEGLVSEYPLVSIEDPLSEDDWDGWQHITNALGGKLQLVGDDLFVTNPERLQKGIDLSAGNSMLVKVNQIGSLTETLDAVDLAHRNGFSTMMSHRSGETEDTTIADLAVAVGSGQIKTGAPARSERVAKYNQLLRIEEELDDAAVYAGAKAFPRSAGFTGRA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: 4CLL8_ORYSJ
Sequence: METELHLAAGYCAATGVYRSGHPPQFAAAAALSFPEYILPHMLLPGRRARPAFVDASTGAALSFAGLRALSLRVARALAAAGLRRGRVALLLSPNSLHFPALSLAVLSLGAVLSAANPLLTPDELARQADDAKPFLALVTGELAPKLRSIAPDVKLVLVEQLLADVAAEVDDDETLDLPAANIGRDDAALLFYSSGTTGRSKGVVSTHGNAIAMAASLERAWGGGGGGGEKPQQYDDHDEAYGCVLPMFHMFGFSSFVMGTAALGATAVVVPGRFSVEKTMAAVEEYGVTRLLVVPPMVVKMVAAAAGDGEPSRRRLRLRQVVSSGAPLQREHMARFRSCFPAVNLGQCYGLTETTGIVTMCDLQHNDNGIDKVEMPPSSTDMTFVAVAATTTEVKERSTGGGGGGGGVSIGRLMPDVEAKIVDPDSGELLPPRRTGELWVRGPSTMRGYLNNEEATALALVAAAGSVSVSGGGERWLRTGDLCYVDSRGLVYVVDRVKELIKCNAYQVAPAELEDVLATHPDIHDAAVAPYPDKEAGEIPMAYVVKKQGSGHLQEDEVISFVQNKVAPYKKIRKVVFVDSIPRSPSGKILRRQLKNLLQGSILHRSRM
What is the function of this protein?
Carboxylate--CoA ligase that may use 4-coumarate as substrate.  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester.
What are the official names of this protein?
Putative 4-coumarate--CoA ligase-like 8.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: MT21A_BOVIN
Sequence: MALVPYTETAEMGLQRFHKPLATFSFANHTIQIRQDWKQLGVAAVVWDAAVVLATYLEMGTVELRGCSAVELGAGTGLVGIVAALLGAHVTITDRKVALEFLKSNVQANLPPHIQPKAVVKELTWGQNLGRFSPGEFDLILGADIIYLEETFTDLLQTLEHLCSNHSVVLLACRIRYERDYNFLAMLERQFTVSKVHYDSEKDVHIYKAQRRCLREDL
What is the function of this protein?
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members.  Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8.  In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
What are the official names of this protein?
Protein N-lysine methyltransferase METTL21A, Methyltransferase-like protein 21A.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL21 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_AERS4
Sequence: MNLHEYQAKKLFAEYGLPVSEGYACATPQEAAEAADKIGGTTWVVKCQVHAGGRGKAGGVKLAKSKDEIRAFAQNWLGKNLVTYQTDANGQPVTKILVESCTDIAKELYLGAVVDRGSRRVVFMASTEGGVDIEKIAHETPELIHKAAIDPLVGPQAYQARELAFKLGLVGDQIKQFTKIFMGLGQMFLDCDFALLEINPLVITAQGNLHCLDGKINIDANALYRQPKLREMHDPSQDDPREAHAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVNLHGGSPANFLDVGGGATKERVTEAFKIILSDSKVQAVLVNIFGGIVRCDMIAEGIIGAVKEVGVKVPVVVRLEGNNAELGARKLADSGLNIIAATSLTDAAQQVVKAAEAK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: SPT_CAUVN
Sequence: MGLFDKHLAYRDAYKAIQDVGANPFKVRFDAVHSPTEGVVDGRPTILLGTNNYLGLTFDEQAIAASVKAVQERGTGTTGSRIANGSFESHVELEQELAKFYGRKHAMVFTTGYQANLGVLSTLVGRGDHLILDADSHASIYDGSRLGHAEVIRFRHNDPEDLAKRLRRLGDAPGERLIVVEGIYSMIGDVAPLKEIAAVKREMGGYLLVDEAHSMGVLGATGRGLAEAAGVEEDVDFIVGTFSKSLGAIGGFCVSDHDDFDVMRVICRPYMFTASLPPAVAASTVTALRRMIEQPELRDRLNRNAKRLYDGLTAMGFLTGPSASPIVAATMPDQERAIAMWNGLLQAGVYLNLALPPATPDSRPLLRASVSAAHTDEQIDAVLKTYGEIGAALGVIEPLKRARA
What is the function of this protein?
Involved in de novo bacterial ceramide synthesis (PubMed:33063925, PubMed:34969973).  Catalyzes the condensation of L-serine with palmitoyl-CoA (hexadecanoyl-CoA) to produce 3-oxosphinganine (PubMed:34969973).  Can also condense serine and C16:1-CoA, but shows a preference for palmitoyl-CoA (PubMed:34969973).
What are the official names of this protein?
Serine palmitoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_SYNWW
Sequence: MYAIIESGGKQYKVAEGSVIKVEKLDVAAGEKLTLDQVLFFNDGNGNVKIGNPLVAGVRVIAEVMEQGKHKKITVFKYKRRKNYRKKQGHRQPYTKIKVEKIEA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: YHEN_BACSU
Sequence: MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKAKEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRLLDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLKEMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYRNSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDTMVPVHE
What are the official names of this protein?
Putative polysaccharide deacetylase YheN.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HEM3_XYLFA
Sequence: MPLLRIATRKSLLAMWQSEYVAARLRMLRPDLDVVLVPMSTRGDEILDRSLAAIGGKGLFLKELELAMLRGDADCAVHSLKDVPMDLEPPFMLAAVLSRDDPADALISNVYLSLESLPIGARVATSSLRRQAQLRFYRPDLRLFDLRGNVNTRLAKLDNGDYDAIVLACAGLRRLGLEQRMTARLAPPEWLPAPGQGAIAVESLTEDARIGTLLAGLDDLPTRQCVVAERTMNRALHGSCHVPVGAYASYEVGGMRLQGLVGCVADGRLVRAELCSAKDEGDMLGRAVAQCLLDAGAAELLAATA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CAST_SOLTU
Sequence: MGSVQDENKDEFKQSLTRGKLKPSSSSSFRLRSPSLNSIRLRRIFDVFDRNHDCLISVEELSQALNLLGLDADLSEIESMVKLHIKPENTGLRFEDFETLHRSLNDVFFGSKCEDKLGLNPDPAQDESDLKEAFDVFDENGDGFISAKELQVVLEKLGLPEGSEIDRVEMMISSVEQDHDGRVDFFEFKDMMRTVIVPS
What is the function of this protein?
Not known.  Probably binds 3 calcium ions.
What are the official names of this protein?
Calcium-binding protein CAST.
Protein: FSHR_MACFA
Sequence: MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAVELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSSLPKLHEIRIEKANNLLNINPEAFQNLPNLRYLLISNTGIKHLPDVHKIHSFQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPSLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGRRASLAEDNEPGYSRGFDMMYSEFDYDLCNEVADVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYTHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSTAHNSHPRNGHCSSAHRVTNGSSYILVPLSHLAQN
What is the function of this protein?
G protein-coupled receptor for follitropin, the follicle-stimulating hormone.  Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
What are the official names of this protein?
Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PA2BC_LATSE
Sequence: MYPAHLLVLLAVCVSLLGASTIPPLPLNLVQFTYLIQCANKGSRASYHYADYGCYCGAGGSGTPVDELDRCCKVHDDCYGEAEKMGCYPKLTMYNYYCGTEGPYCNTKTDCQRYVCACDLQAAKCFARSPYNNKNYNIDTSKRCK
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 cPt09, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARO1_ASHGO
Sequence: MASVGLEKVNILGRDSIHVGYDLRAHIARTVFESCVSSTYVVVSDANVARVPYHEALCAALEEGLPARSRMLRYVVQPGETYKTRETKGEIEDFMLAEGCTRDTVVLAVGGGVIGDMVGFVAATFMRGVRFVQVPTSLLAMVDSSIGGKTAVDTPAGKNFIGSFWQPEFVFVDVKWLETLPRREFINGMAEVIKTACIWNAAEFMRLEMHASMFLQVVNSSKQVKVDTKGGPTSLSYTNITQILDHVFQLVLESIKVKAHVVSSDERESGLRNLLNFGHSIGHAYEALLTPQALHGECVSIGMVKEAELSRYLNILSPTQVARLTKVLSAYGLPTSVNEGWFRELTLGKRTPLEVLLRKMSIDKKNDGSNKKVVLLETIGKCYGTSAHVVSDTDLRFVLTDEALVYPFTDVRSSTGHTIVPPGSKSISNRALILAALGKGKCRIRNLLHSDDTKHMLEAVQQLNAATISWEDNGDTVVIDGHGGRTLTASDLPLYLGNAGTASRFLASVASLVCPEGNRDSVILTGNARMQERPIGPLVESLRLNGVRVDYLNREGSLPIKVHAESKFRGGRINLEASISSQYVSSILMCAPYAEEPVTLSLDGKPISELYIEMTIRMMEKFGIKVEKSNDELYTYHIPRGQYVNPAEYVIESDASSATYPLAFAALTGTTVTIPNIGHDSLQGDSRFACDVLKPMGCTVQQTATSTTVTGPEPGTLKPLEHVDMEPMTDAFLTACVVAAAAHSPESKCKNIITITGIANQRVKECNRILAMVTQLSKFGVTAEELPDGIQVHGVEQLSQLKVPDAVETYDDHRVAMSFSLLAGMVNYGQAPSSCRPIKILERRCTGKTWPGWWDVLHSRLGATLDGNEPLPEKENDIRKSVVLIGMRAAGKSTVGRWCAEALGYKLLDLDDEFQTYFGMGTVKEFVAQNGWESFRSKETDLFGHVLNKYSRSGYVISTGGGIVETASSRKLLQDFAATGGVVLHLYRDIDETIKFLRTDPTRPAYIEEVRGVWDRREKWYHLCSSYSFFSPHCSTTAEFEGLRRVFSKFIRRITGMLPVEVPVKRSTFVCLTFQNLLPEMERIKEAVYGCEAVEVRVDHLENYSQDFVLKQLTALRLATDSLPIVFTIRTKKQGGKFLDNDYSTLEDLLTVGLKAGVEFLDLELTLPSPIHQRILNKRYKTRIIGSHHDFSGEFSWEHPEWEHRYAQALAMQVDAIKFVATAKGFGDNLSLEEFRSKHTDKPLIAINMRECGKLSRVLNTILTPITSDVLPQAAAPGQLTLRQINELYASIGGLRPKKMFVVGSPIGHSRSPILHNTGYNSLGLPYTFDKFETDSAEIVKKSLLSREDLGGIAVTIPLKQDIMQYLDELTDSAKCIGAVNTIIPKKDGRFIGHNTDWLGIKNSLIANGVPEHVNTAGLIVGSGGTARAAAYAFHEMQCSTIYMINRTTSNLTELQKSFPQEFNIHVIESLEQIEQLSEPVGIAVSCVPSDKPLDDALSQKLSAFLSRPSATNFIPTILDAAYKPLVTPVLKLASEVHGWRPVSGAQMLVHQGVAQFEIWTGFKAPFAPVYDAVTQE
What is the function of this protein?
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
What are the official names of this protein?
Pentafunctional AROM polypeptide.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the shikimate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C7A44_SOLLC
Sequence: MELLYVCLVCVFVFLVSLLLLYKKKSGEGLPPGKTGWPVFGESLEFLSSGWKGHPEKFIFDRVAKYSSSVFKTHLLGEEAAVFCGASANKFLFSNENKLVQAWWPNSVNKVFPSSTQTSSKEEAIKMRKMLPNFFKPEALQRYVGIMDHITQRHFATGWENKEQVVVFPLTKRYTFWLACRLFLSVEDPKHVAKFADPFDVLASGLISIPIDLPGTPFNRAIKASNFIRKELVRIIKQRKIDLGEGKVSSTQDILSHMLLTCDENGKFLGDLDIADKILGLLIGGHDTASSACSFIVKYLAELPHIYQRVYTEQMEIAKSKGPGELLRWEDIQKMKYSWNVACEVLRLAPPLQGAFREALSDFMFNGFYIPKGWKIYWSANSTHKREEFFPDPEKFDPSRFEGSGPAPYTFVPFGGGPRMCPGKEYARLEILVFMHHLVKRFKFEKIIPHEKIIVNPMPIPANGLPLRLYPHHHNP
What is the function of this protein?
Catalyzes the carboxylation of beta-amyrin at the C-28 position to form oleanolate (PubMed:28194155).  Catalyzes the carboxylation of alpha-amyrin at the C-28 position to form ursolate (PubMed:28194155).
What are the official names of this protein?
Beta-amyrin 28-monooxygenase, Beta-amyrin 28-oxidase, Cytochrome P450 716A44.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CPXG_STRSQ
Sequence: MTQAAPVTFSTVRENYFGPPAEMQALRHKAPVTRTAFADGRPGWLVTGYSAARAVLSDSRFTARGEREHPAVPRAATLEDERCRRLIAGQFTARRMRQLTGRTERIVREHLDAMEHMGSPADLVEHFALPVPSLVIAELLGVPPPDREHFQHDTLRWGGFGRSTEEVTEAFVSLGGQLQRLVRLKRTEPGDDLLSGLIAADPALTDEELASIAFLLLVAGHGTTAHQIALGAFLLLEHPDQLAALRADPALTESAVEELLRHLSVVHHGPTRAALQDADIEGTPVKAGEVVVVSLGAANRDPARFERPDAVDVTREDTGHLAFGHGMHQCLGRQLARIELRVALTALLERFPHLRLACPAAEIPLRHDMQVYGADRLPVAW
What are the official names of this protein?
Cytochrome P450 105C1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_PARUW
Sequence: MYAIIKTGGKQYRVQEGDIIDVELLNTDPGAQVEFGEVLFAFDGAKTQIGKPGIPNFLVYGEVVGTVKGEKVTSLKYKPSHNQCRKWGHRQHYTRVKITGIGSKRKGKEGNHGS
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: NCAP_PI2HT
Sequence: MSSVLKTFERFTIQQELQEQSDDTPVPLETIKPTIRVFVINNNDPVVRSRLLFFNLRIIMSNTAREGHRAGALLSLLSLPSAAMSNHIKLAMHSPEASIDRVEITGFENNSFRVIPDARSTMSRGEVLAFEALAEDIPDTLNHQTPFVNNDVEDDIFDETEKFLDVCYSVLMQAWIVTCKCMTAPDQPPVSVAKMAKYQQQGRINARYVLQPEAQRLIQNAIRKSMVVRHFMTYELQLSQSRSLLANRYYAMVGDIGKYIEHSGMGGFFLTLKYGLGTRWPTLALAAFSGELQKLKALMLHYQSLGPMAKYMALLESPKLMDFVPSEYPLDYSYAMGIGTVLDTNMRNYAYGRSYLNQQYFQLGVETARKQQGAVDNRTAEDLGMTAADKADLTATISKLSLSQLPRGRQPISDPFAGANDREMGGQANDTPVYNFNPIDTRRYDNYDSDGEDRIDNDQDQAIRENRGEPGQPNNQTSDNQQRFNPPIPQRTSGMSSEEFQHSMNQYIRAMHEQYRGSQDDDANDATDGNDISLELVGDFDS
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The nucleocapsid (NC) has a helical structure.  The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.  During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NP, Protein N.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses nucleocapsid family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: TATB_SHEB2
Sequence: MFDGIGFMELLLIGVLGLVVLGPERLPVAVRSITSWIRAMKRMANSVKEELEQELKIEQLHADLKKAESKGLSNLSPELKESIEQLKQAAQSVNRPYQVQDPVKDTPAPENQIHSPVASTVQTSPAQASQANPTATVEASPTSASPATPSEPSQGADTRSNPKANG
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: EFG_MYCGI
Sequence: MAQDVLTDLSKVRNIGIMAHIDAGKTTTTERILYYTGVNYKIGETHDGASTTDWMEQEQERGITITSAAVTCFWNQNQINIIDTPGHVDFTVEVERSLRVLDGAVAVFDGKEGVEPQSEQVWRQADKYDVPRICFVNKMDKLGADFYFTVRTIEERLGARPLVIQLPIGAENDFIGIIDLVEMKAKVWRGETALGEKYEVEEIPADLADKAEEYRTKLIEAVAETDEALLEKYFGGEELSIDEIKGAIRKLTVASELYPVLCGSAFKNKGVQPMLDAVIDYLPSPLDVESVTGHVPNKEDEVISRKPSTDEPFSALAFKIAVHPFFGKLTYVRVYSGTVESGSQVINSTKGKKERLGKLFQMHANKENPVERASAGHIYAVIGLKDTTTGDTLCDANQQIVLESMTFPDPVIEVAIEPKTKSDQEKLGTAIQKLAEEDPTFKVHLDQETGQTVIGGMGELHLDILVDRMRREFKVEANVGKPQVAYRETIRRKVEKVEFTHKKQTGGSGQFAKVLIDLEPFSGEDGATYEFENKVTGGRIPREYIPSVDAGAQDAMQYGVLAGYPLVNIKVTLLDGAFHEVDSSEMAFKVAGSQVLKKAAQAAQPVILEPIMAVEVITPEDYMGDVIGDLNSRRGQIQAMEERSGARVVKAQVPLSEMFGYVGDLRSKTQGRANYSMVFDSYAEVPANVSKEIIAKATGQ
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBM5A_XENLA
Sequence: MGSDKRVSRSERSGRYGSGFDRDDRDDRDNRSRRRDSEYKRYRDERSDRYDDYRDYDSPERDRMRDRERRNSDRSEDGYHSDGDYMDHDYRQDYYMDEKESKTIMLRGLPININENDIRELVESFEGPQPADVRLMKRKTGLSRGFAFVEFYHLQDSTSWMEANQKKLVIQGKTIAMHYSNPRPKFEDWLCNKCGLYNFRRRLKCFRCGAAKAESDMEAPSGSSEAPQSADYYSDSGYVSSAIILRNIGPHTVVDSILSALAPYVSLVVSNIRLIKDKQTQQNRGFAFVQLPSALEASQLLQILQTLHPPLKIDGKTIGVDFAKSARKDLVLPDGHRVSAFSVASTAIAAAQWSSTQPAQQSGEGGDYAYLQPGQEGCSNYGQCSQDYQPFYQTQTGAAEQGTAPQAESSSPVPATTSAVVCQSPQMYQQPGSPTQSSTSTVAASATPASGTSAEEAAAPNAIVPGLKYSVPDTSTYQYDESSGYYYDPQTGLYYDPNSQYYYNSLTQQYLYWDGEKQTYLPAADGAGQSGTQPNGANPGTSKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPLRDEERKESAAADAGFALFEKKQGSLLERQFLPDMMMMVNTEEEKPPNTALVAAYSGDSDNEEENERFIGAVDDEKLMDWKKLACLLCRRQFPNKDALTRHQQLSDLHKQNLEVYRRSKLSEQEYEAEQTERESKYRDRAAERRVKYGIPEPPEPKRKRFAPTVVNYEQPTKDGIDNSNIGNKMLQAMGWKEGSGLGRKSQGITAPIQAQVRMRGAGLGAKGSSYGVNTSDSYKDAVRKAMFARFSEME
What is the function of this protein?
Component of the spliceosome A complex.  Regulates alternative splicing of a number of mRNAs.  May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity).
What are the official names of this protein?
RNA-binding protein 5-A, RNA-binding motif protein 5-A.
What is the protein family that this protein belongs to?
Belongs to the RBM5/RBM10 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KAPCB_MOUSE
Sequence: MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF
What is the function of this protein?
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs.  PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:9368018).  Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.  Phosphorylates GPKOW which regulates its ability to bind RNA (By similarity).
What are the official names of this protein?
cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
Protein: CRGC_HUMAN
Sequence: MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin C, Gamma-C-crystallin, Gamma-crystallin 2-1, Gamma-crystallin 3.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: ATPD_LAWIP
Sequence: MIGDIIAQRYAQALFDLGKEQSLHEVELYDTALSQIEELLMTSNELTYFLHAPIFTIYEKQGVLLKLLELIDAAQPIKNFCLLLAEKERLPLLTQIINSFKVLLDNAKNIVHGQLITAITLDEKKQSELLISLEKQTNRKLELLFQVNPDILGGIVLHIGDKVFDASLRTQLECIRNTIKKGETNHAY
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.