PharMolix/UniProtQA huggingface dataset:
Protein: C1QT1_RAT
Sequence: MGSRGQGFMLGCCLLLAVTWGPVLSLVPRVQEEQQEWEETEELTSPLDHVTRPEETHKRYSPSLREGLPTSRCYRCCDSNPPVYQTIPPPQINITILKGEKGDRGDRGLQGKYGKIGSTGPRGHIGPKGQKGSMGAPGDHCKSQYAAFSVGRKKALHSNDYFQPVVFDTEFVNLYNHFNMFTGKFYCYVPGIYFFSLNVHTWNQKETYLHIMKNEEEVVILYAQVSDRSIMQSQSLMLELREQDEVWVRLFKGERENAIFSDEFDTYITFSGYLVKPASEP
What are the official names of this protein?
Complement C1q tumor necrosis factor-related protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: RL15_SHIB3
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: NFUA_ECO5E
Sequence: MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEATDTALKFDLLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVADDAPLMERVEYMLQSQINPQLAGHGGRVSLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEKQLLNEFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: UVRB_THIDA
Sequence: MFVTFPDSPFRLFQPFPPAGDQPTAIARLIEGIDDGLSYQTLLGVTGSGKTYTMANVIARAGRPALIMAPNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPARDLFIEKDSSINEHIEQMRLSATKSLLERRDTVIVCTVSAIYGIGDPSDYHSMILLLRQNDKMTQREVIARLTQMQYDRNDVDFKRGVFRVRGDVIDIFPAEHAETAIRVELFDDVVETLHLFDPLTGQILQKVSRFTVFPSSHYVTPRETTLRAIEAIKVELRERLDWYYANNKLVEAQRLEQRTRFDLEMMVELGFCKGIENYSRHLSGRKAGEPPPTLIDYLAKDALMFIDESHVTVTQVGGMYKGDRSRKENLVDYGFRLPSALDNRPLKFEEFEALMPQTVFVSATPAKYEAEHAGQVVEQLVRPTGLIDPIVEVRPVTTQVDDLMSEVKKRVAVGERVLVTTLTKRMAEDLTDYLAEHGVKVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARHLNGTAILYADRITDSMQRAIGETERRRAKQIAFNTEHGITPRGVVKRIKDIIDGVYDADASRQELKAAQTAAEYKVMDEKSLTKRVKKIEKEMQDAAKNLEFEKAAVLRDQLKELKALLFGVEERE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADEC_ECOLC
Sequence: MNNSINHKFHHISRAEYQELLAVSRGDAVADYIIDNVSILDLINGGEISGPIVIKGRYIAGVGAEYADAPALQRIDARGATAVPGFIDAHLHIESSMMTPVTFETATLPRGLTTVICDPHEIVNVMGEAGFAWFARCAEQARQNQYLQVSSCVPALEGCDVNGASFTLEQMLAWRDHPQVTGLAEMMDYPGVISGQNALLDKLDAFRHLTLDGHCPGLGGKELNAYITAGIENCHESYQLEEGRRKLQLGMSLMIREGSAARNLNALAPLINEFNSPQCMLCTDDRNPWEIAHEGHIDALIRRLIEQHNVPLHVAYRVASWSTARHFGLNHLGLLAPGKQADIVLLSDARKVTVQQVLVKGEPIDAQTLQAEESARLAQSAPPYGNTIARQPVSASDFALQFTPGKRYRVIDVIHNELITHSHSSVYSENGFDRDDVSFIAVLERYGQRLAPACGLLGGFGLNEGALAATVSHDSHNIVVIGRSAEEMALAVNQVIQDGGGLCVVRNGQVQSHLPLPIAGLMSTDTAQSLAEQIDALKAAARECGPLPDEPFIQMAFLSLPVIPALKLTSQGLFDGEKFAFTTLEVTE
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: NRDR_BACLD
Sequence: MKCPACQHNGTRVLDSRPVDEGRSIRRRRECESCNYRFTTFEKVEEIPLIVVKKEGIREEFSREKMLRGLIKACEKRPVALKQLEDICFEIEKELRNQGVSEVKSDMIGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PURL_ALKCK
Sequence: MSQLLEPSAETIKAERLYREMGLTDDEFALAEKIVGRPLNFTETGLFSVMWSEHCSYKNSKVLLKKFPTDGENVLQGPGEGAGIIDIKDEQAVVFKIESHNHPSAIEPYQGAATGVGGILRDVFSMGARPVALLNSLRFGELESKKVKYLFEEVVAGIAGYGNCVGVPTVGGEVQFDPCYESNPLVNAMCVGLIDHKDIQKGQAKGVGNTVMYVGASTGRDGIHGATFASEELSEDSDAKRPAVQVGDPFMEKLLLEACLEVVQSDALIGIQDMGAAGLVSSSAEMASKAGSGIEMNLDLVPQREAGMTPYEMMLSESQERMLLVVEKGREHEIKATFERWNLHAVEVGVVTDDRRLRLTHKGEIVADVPVDALAEDAPVYHKPSKVPAYFDAFQQQAPYIPEITEANETLLKLLAQPTIASKEWVYEQYDYMVQTNTVVEPGSDAAVIRIRGTNKALAMTTDCNSRYLYVDPEMGGKIAIAEAARNLVCSGAKPLGVTDCLNYGNPEKPEIFWQLEKSTDGLSEACRELGTPVIGGNVSLYNERSGGAVYPTPVIGMVGLVEDVAHITTQSFKNAGDLIYVIGETKAEFGGSELQKMLVGELSGKAPEIDLAVEKSRQQQLLSAIKQGLVQSAHDVAEGGLAVSLAEKMMECPFGAEVSLSLSAAELFAESQSRFIVTVKPSDQQRFENTVLDAVVVGAVTESRKLTIRNENGNAVIDLCQDELVKAWKGAIPCLLKSKA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_PHOPR
Sequence: MSSDQVHLGHRARKRFGQNFLNDPYIIDGIVSSINPLPGQNLVEIGPGLGALTEPVGRLVDKFSVIELDRDLAKRLRHHPDLADKLTIYEGDAMRFDFTQLIKPNNKLRIFGNLPYNISTPLMFHLFTFHEHVEDMHFMLQKEVVNRLAAGPGCKAYGRLTVMAQYYSRVTPVLEVPPESFTPAPKVDSAVVRLTPYEVLPHPCTNLKWLDRVCREGFNQRRKTIRNCYKALLTVEQLEDLGVNPGLRPENITLQQFVKMANWLDANHQNA
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_SYNC1
Sequence: MTERFVTPDFSSEEDRLEASLRPRVLTEYIGQSKAKGNLQVFIDAARGRQESLDHVLFYGPPGLGKTTLANIVASEMGVSIKSTSGPVIEKPGDLAAILTNLSDGDVLFIDEIHRLSPVVEEILYPAMEDYQLDIIIGQGPSARTIKLDIPRFTLVGATTRAGLLSSPLRDRFGVICRLEFYTDDELATIAGRSARILDIPIEKDGQYEIARRSRGTPRIANRLLRRVRDFAQVKGDGIITRDIADMALSRLEVDNCGLDHMDRLLLLAIIDKFAGGPVGLETLAAAVGEEKDTIEDVIEPYLLQNGFLNRTPRGRTATERAYRHFQRQIPRGKTSGELFS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LCP82_DROME
Sequence: MKFLIVFVALFAVALAAPAAEEPTIVRSESDVGPESFKYDWETSDGQAAQAVGQLNDIGTENEAISVSGSYRFIADDGQTYQVNYIADKNGFQPQGAHLPVAPVA
What is the function of this protein?
Component of the cuticle of the larva.
What are the official names of this protein?
Larval cuticle protein 65Ag2, Larval cuticle protein 8.
Protein: RL3_BRUSU
Sequence: MRSGVIAQKLGMTRVYNDAGEHVPVTVLRMENCHVVAQRTVEKNGYTAVQLGVGVAKVKNTSKAMRGHFAKAEVEPKAKLAEFRVSPDNLLEVGVEITAEHFVAGQKVDVTGTSIGKGFAGVMKRHNFGGHRASHGNSITHRSHGSTGQRQDPGKVFKGKKMAGHMGQTRVTTQNIEVVSTDSDRGLILVRGAVPGSKGAWILVRDAVKASLPENAPKPAGLRAGAKAEAAATEGAE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: BIOH_SHISS
Sequence: MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSQGFGALSLADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDDWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVPMPFLRLYGYLDGLVPRKVVPMLDKLWPRSKSYIFAKAAHAPFISHPVEFCHLLVALKQRV
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_DICT6
Sequence: MAAKLVSLDMQARTALIRGLDIVADTVKITLGPKGRNVVLEKKFGAPVITNDGVTIAKEIDLEDPFENMGAQLVKEVASKTNDVAGDGTTTATVLAQALVHEGMKHVVAGANPMYVRRGIEKAVEKVVEELKKIAKPVETKQDIAHVAAISANNDTEIGNLIAEAMDKVGKDGVITVEESQGITTTLELVEGMQFDRGYLSAYMITDPERMEAVLEEPYILITDRKISAVSEILPILERVVQTGKPLVIIAEDVEGEALATLVVNKLRGVLQSLAVKAPGFGDRRKAMLQDIAILTGGQFISEETGIKLENVTLDMLGRAEKVRANKDKTTIIGGKGNKKDIEARIAQIKKQLEETDSEFDREKLQERLAKLAGGVAVIKVGAATEVELKEKKHRIEDALSATKAAVEEGIVPGGGVALLRTIKALDDVKVDNEDERIGVEIVRRSLDVPLKLIANNAGKEGSIIAEKVKEMDGPMGYDAANDRFVNMFEAGIVDPAKVTRSALQNAASIAALVLTTEGLVAEKPEKEKQTPPPPPEY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_PSECP
Sequence: MNWFEVALLGLVQGLTEFLPISSSAHLRIVGQFLPNAEDPGAAFTAITQLGTETAVVVYFWRDIVRIVKAWAGSLAGKVSRQDPDARMGWLVILGSLPIIVLGLLFQDQIESVLRSMWIVATMLIVFGLILAVADAVGKQERDLTQLTYKHGILYGFAQAMALIPGVSRSGGTITAGLLMGYTREAAARYSFLLAIPAVFGSGLYQLYKVVSKDGITGPYGLPETALATVIAFVVGYVIIGWFLKFVSTRSYRLFVWYRIFLGLALYLLLGFGVISA
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS19_EHRCR
Sequence: MSRSIKKPPFCAPHVLRLVNKAIAQNKLNSIINIHSRSSVILNKFIGLTFGVYNGKTYVPVKVNDNMVGRKFGEFSPTRRYTGHVGDKKVSRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SECF_RICPR
Sequence: MQIYPLRFVPNKIDFDFMNFKKVSYSFSIILSLISLIWISIYKFNFGIDFVGGIVIEVRLDQAPDLPKMRAVLSALEIGEVVLQNFGSERDLSIRFGSSSEENLMKNIDIIKTSLRNNFPYNFEYRKVDFVGPQVGRQLIEAGAMAMLFSFLAIMVYIGVRFEWYFGFGILIALVHDVILALGFMSMTKLDFNLSTIAAVLTIIGYSVNDSVVIYDRIRENLRKYHKKNITEIINLSINETLSRTILTVITTLLANLALILFGGKAIHSFSVLVFFGIIAGTYSSIFISAPILTMFANRKFNKKVITQGKG
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecF.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRMFO_THEVB
Sequence: MEPITVIGGGLAGTEAAWQIARAGLPVVLYEMRPQVASPAHHTAELAELVCSNSFGAKASDRATGLLHHELRALGSLIIATADRHQVPAGGALAVDRAHFSRELTETLENHPLVTVRREELPHLPESGIVVLATGPLTSEALSADLQCFTGLDYLSFFDAASPIVVGESINREVAFLASRYDRGEAAYLNCPFSAEEYQRFWQALCEAKQAPLKDFERENAQFFEACLPVEELARRGVDTLRFGPLKPVGLRDPRTGERPYAVAQLRQEDRHGQLWNLVGFQTNLRWGEQQRVFRMIPGLEQAEFVRMGVMHRNTFLNAPKLLKASLQFRDRPTLLAAGQITGTEGYTAAAAGGWLAGTNAARLARGLAPLVLPPTTMAGALFHYISTAESKTFQPMPPNFGILPPLEQPVRQKALRYAAYRDRALKDLSTWATAMSLPLQPLALDGCDPAAVEAGA
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG8_EMENI
Sequence: MRSKFKDEHPFEKRKAEAERIRAKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGDC
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier atg8.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor. Preautophagosomal structure membrane; Lipid-anchor.
Protein: RNFH_ECO45
Sequence: MPGKIAVEVAYALPEKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSRPAKLSDIVHDGDRVEIYRPLIADPKELRRQRAEKSANK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: CAS1C_METRM
Sequence: MKILIEGYNKSIHKRDNQILIMEKEGELEKINIKKIDDITIIGKGSITFDALRLISENNVRLMSIDYFGKINYTLEYPSNENIFLRKQQYKTSENHKGLIIAREMIMSKMINQKSTIKTLNKNKKLENVKIFERNINEAIKQIGSLRFGERTDIEKSKMKMMGIEGSASVDYWLAVNELLPKEIGFFSRNNRHPNDITNASLNYAYAILASEVNKALVINGLDSYCGFLHFDRQKRTSLTFDLMEEFRQQLVDKVVFSLVNTKQISNDDLDKRNNSISLDVRKLIIGRVLDKVNSNINYEGENLSYAQIIDKQAKKIVNYLINGEKYTGFSLRW
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Acts as a dsDNA endonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated protein Cas1 3.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endonuclease Cas1 family.
Protein: MNO_RHOER
Sequence: AIELNQIWDFPIKEFHPFPRALMGVGAHDIIGVEAKNLGFKRTLLMTTGLRGSGIIEELVGKIEYQGVEVVLYDKVESNPKDYNVMEAAALYQKEKCDSIISIGGGSSHDAAKGARVVIAHDGRNINEFEGFAKSTNKENPPHIAVSTTAGTGSETSWAYVITDTSDMNNPHKWVGFDEATIVTLAIDDPLLYYTCPQHFTAYCGFDVLAHGSEPFVSRLDFAPSLGNAIYSVELVAKNLREAVFEPRNLKAREGMMNAQYIAGQAFNSGGLGIVHSISHAVSAFFDSHHGLNNAIALPRVWEYNLPSRYERYAQLAGALGVDTRNLTTVQAADAAVEAAIRLAKDVGIPDNFGQVRTDSYAKNQMNTKKYEGRGDVIKGDEKTVRAISEHIQDDWCTPGNPREVTVESMIPVVDHAINKSYF
What is the function of this protein?
Catalyzes the oxidation of methanol to yield formaldehyde.  While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA) can serve this function in vitro and is reduced to 4-(hydroxylamino)-N,N-dimethylaniline.
What are the official names of this protein?
Methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, MNO, Methanol dehydrogenase (nicotinoprotein), Methanol:NDMA oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
Protein: NUOK_OPITP
Sequence: MIPATLNTYLVLSAVLFAIGFIGVLFRRNTLILFMGLELMLVASTLGFVAFSRFNGTGGGNVFVFFILTVAAAEVAVGLAIIVALFRKRQTVEVDELNSLKN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDGFA_MOUSE
Sequence: MRTWACLLLLGCGYLAHALAEEAEIPRELIERLARSQIHSIRDLQRLLEIDSVGAEDALETSLRAHGSHAINHVPEKRPVPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATSNLNPDHREEETGRRRESGKNRKRKRLKPT
What is the function of this protein?
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.  Potent mitogen for cells of mesenchymal origin.  Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis.  Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum.  Plays an important role in wound healing.  Signaling is modulated by the formation of heterodimers with PDGFB.
What are the official names of this protein?
Platelet-derived growth factor subunit A, PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted. Note=Released by platelets upon wounding.
Protein: TRMN6_HAEIE
Sequence: MSGFTFKQFHINQNSCAMKVSTDGILLGAWADVKHCKNILDMGSGTGLLALMLAQRTEENCQIQAVELDPIAAKQAQENINNSVWKNRIQLIQTDIQHFLQTTAQTFDLIVANPPYFEQGIACKNEERELARYTKQSHLNWLEWAATRLSENGRISFVLPYDAGKTLIKSTALFCIKQTNVITKIGKTPQRMLLTFAKQPQVLMQDQLVIYDADNQYTEAFIELTKDFYLKF
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_VIBCH
Sequence: MQVTVETLEGLQRRLNITVPAANIEDAVAAELRNIAKNRRFDGFRKGKVPMKMVAKMYGKAVRQDVLGEVMQRHFIEAIVKEKINPAGAPTFAPVEIGEGKDLVFTATFEVYPEVELKGLENIAVEKPAAEVTDADVAEMLETLRKQQATWKEVDEAAENGKRVSIDFVGSIDGVEFEGGKAENFPLEMGAGRMIPGFEDGIVGKTKGMEFVIDVTFPEDYHAENLKGKAAKFAIKVNKVEARELPELNDEFVARFGVAEGGVDALKAEVRKNMERELKQAIKARIKEQAIEGLVKENEIQVPSALIDQEINVLRQQAAQRFGGNVEAAAQLPRELFEEQAKRRVVVGLLLGEVIRTHELKADEEKVKALITEMATAYEDPSEVVSYYEQNQQLMNNMRNVALEEQAVDAIIAKAKVTEKAISFSELMNPVAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: HISX_CAMJE
Sequence: MQILVYDNLDEKQKEEALKRPAISAKDEISKIVSSIIKEVQEKGDKALIEQALKFDKAEISKIKITQEEITQASNRLDKDLQEAILVAYENIKKFHEAQIPHEIALETTKGVKCEVLTRPIEKVGLYIPGGLAPLFSTVLMLAIPAKIAGCEKIVLASPAKINDAVLFCAKLCGVDEIYQMGGAGAIAALTYGTQSVLKVDKIFGPGNAFVTEAKRQVSSDINGAAIDMQAGPSEVLVIADDLANEKFVASDLLSQAEHGADSQVILVCLSQDFAKKASDEVQSQLELLPRKELASKSIANSRIIIAKDLNQALEISNLYAPEHLIIQTQNPRELLKGVKHAGSVFLGAYSPESMGDYASGTNHVLPTYGLTKTHSSLGLADFSKRMTVQELSKEGFLALGKSVEILAQNEHLDAHKNAVTFRLESLK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.