PharMolix/UniProtQA huggingface dataset:
Protein: SYA_XANAC
Sequence: MNAPAKFSTSQIRSDFLAFFEGKGHTIVPSAPLVPGNDPTLLFTNSGMVQFKDVFLGAEKRSYVRAADVQRCLRAGGKHNDLDSVGYTARHHTFFEMLGNWSFGDYFKKDAIAWAWELLTQVWKLPADRLLVTVYHTDEEAFALWRDVIGIPESRIVRIGDNKGAPYASDNFWQMADTGPCGPCTEIFFDHGDHIAGGPPGSPDEDGDRFIEIWNLVFMQFDRQPDGTLVPLPAPCVDTGMGLERLAAILQHVHTNYEIDLFQTLIGKAGSLTGVADLENKSLRVIADHIRACSFLIVDGVLPSNEGRGYVLRRIIRRALRHGWMLGVRQPFFSKMVPTLVELMGEAYPELVVAKDTVARALSAEEERFAETLDAGMKIFDEVASRSQDIIPGADAFRLYDTYGFPVDLTADIARERGMRVDMEGFEFAMERQRETARAAGKFGGGVALPADLVASMSPTVFLGYEAYDADALKVVAILRQGRPVERAEAGDEVIVFTDRTPFYAESGGQVGDSGQLSGPGVSVEVADTQKFAGQFHGHVGRISEGALALGDVLAGEIDTQRRGKTILNHSATHLLHAALREVLGTHVQQKGSLVAPDRLRFDFSHFQPITADELAVIERKVNAEVRTNHGVEVHNMAMQEALDFGAMALFGEKYGENVRVLKMGGYSTELCGGTHVTRTGDIGLFKITSEGGVSSGVRRIEAVTGQGALDYVADEERRLLEAANLLGGNTTEVVDKVRALTERQKRLERELESLKAKLASGATADLGARAIDVAGVKVVAVRLEGFDAKALRDAMDRLKQQLGDSVIVLAGASGGKVALVAGVNGSPTGKVKAGELLGHIASQIGGKGGGRPDLAQGGGEDGPALATALDGVPLWVKQHLG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_CITBB
Sequence: MNLILLGPPGVGKGTQAKLLIDRFGIPQISTGDILRAAVKELTPMGAKAKGYMDSGALVPDEVVIGIVEERLAQADCQKGFILDGFPRTVPQADALGQVLSGMGKSIDHVVSLSVDKGELLKRLTGRRACANCGAGYHVDFAPSKVAGVCDACSGQLVQREDDKEETILNRLAVYEAQTAPLIAYYQAAGLLRSVDGLGTVEGVQSGILAAIRA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_HAEI8
Sequence: MTEQKQVKKPSARRRARECTVQALYSWAVSGNTAEQVELAFVLDQDMDGVDKPYFRKLFRQTVENIETVDFSISPYIDRAFDELDPIETAILRLAVYELCFELDVPYKVVINEAIEVAKVFGADESHKYINGVLDKIAPALGRK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: TMM68_CHICK
Sequence: MIGSNESSTEGPIPTSYLSFLAYLLGEWTGVEHTEDYLSYGAYLSWVLFPLAIVFILPVAIFFFCFNTSLLLLHIYKRRKNGFNEGHSGDVWYGAKEMLVNLWDGHGRVWHGYELHGDENIPEVPALIVFYHGASPVDYLYFMARLLIRRKRYCHVVADHFVFRLPGLKMFIEVLGVMHGPKEVCVSALKKGYLLAISPGGVREALFSDETYAIMWGNRKGFAQVAIDAKVPIIPMFTQNVREGIRTLGGIKIFRKLYERIRLPIVPMYGWFPVKFRTFIGEPIPYDPNITAEELTAKTKAALQALITKHQKIPGNILRALMERFQTRQKED
What are the official names of this protein?
Transmembrane protein 68.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HUTH_BACMK
Sequence: MITLTGHTLTVEEMKRLLLEGEGVTACPTSMQKVAECREVVEKIVEDGKVVYGITTGFGKFSDVLIQKDDVKALQHNLIQSHACGIGDPFPEEVSRGMLILRANTMLKGVSGVRPLVVNMLLEFVNRKIHPVVPQQGSLGASGDLAPLSHLALVLLGEGEVFYKGKRVHAMVALTEEGLEPIELEAKEGLALINGTQAMTAQGVLSYIEAEASAYQSELIASMTMEGLRGIIDAFDENVHKARGYKEQVEVASRIRDILHDSKLVTKQGELRVQDAYSLRCIPQVHGASWQVLNYVKEKLEIEMNAATDNPLIFDGGEKVISGGNFHGQPIAFAMDFLKVGMAELANISERRIERLVNPQLNDLPPFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTIASRHAHQIIQNARRVLAIEMICAMQAAEYRGIENMSTVTKTFYHQGRQQVPSITNDRIFSTDIENIAHWLKTNYSIKERLDVNAAL
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_CLOBB
Sequence: MSVTKKDVEYVAELARLSFNEDEKESLASDLNQILNYVEKLQELDTEKEDIIVNPYYIENKFREDEITPSIKLEEVLENAPKTLEEYVLVPTIIREQ
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: GUAA_BACFN
Sequence: MQEKIIILDFGSQTTQLIGRRVRELDTYCEIVPYNKFPKGDETVKGVILSGSPFSVYDESAFKVDLSEIRGKYPILGICYGAQFMAYTNGGKVEPAGTREYGRAHLTSFCKDNVLFKGVREGTQVWMSHGDTITAIPENFKTIASTDKVAIAAYQVEGEQVWGVQFHPEVFHSEDGTQMLRNFVVDVCGCKQDWSPASFIESTVAELKAQLGDDKVVLGLSGGVDSSVAAVLLNRAIGKNLTCIFVDHGMLRKNEFKNVMHDYECLGLNVIGVDASEKFFSELEGVTEPERKRKIIGKGFIDVFDEEAHKLKDVKWLAQGTIYPDCIESLSITGTVIKSHHNVGGLPEKMNLKLCEPLRLLFKDEVRRVGRELGMPEHLITRHPFPGPGLAVRILGDITPEKVRILQDADDIFIQGLRDWGLYDQVWQAGVILLPVQSVGVMGDERTYERAVALRAVTSTDAMTADWAHLPYEFLGKVSNDIINKVKGVNRVTYDISSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: Y485_METJA
Sequence: MVEINLRELKKYANPFFLTIRKDKILVNNKRMARLSRTKMDKIEEEFGIPVIYSKTYEYVSTKVGRFINKHKIIAPRDIVIVGLSGGKDSLLLLHLLEVYRRKYGIKLIAVTVDVNIGGIRPWKEDTEGVKLIKHHCEMLNVPHIILKNDLDVVELSEILTKHSKGMEFSPCFSCSVIKRHLLGKLAKEIAENENIPYEKVKLAYGHNLDDNSDTILANIFKGERLKFMRPLTRFKYNEVDYQSFKIPLEECIIIRPMLPILERDIIKALEECGIEYYKDKDMCPYSRDRGDSVRRRCHEILEKLEEEIPNIREMVVSSALKTVEYYSKNPYGEDNL
What are the official names of this protein?
Probable sulfurtransferase.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
Protein: UPPP_GEOSL
Sequence: MDIMHAAVLGILQGLTEILPISSSAHLILVPWLLGWPESGLTFDVGLHVGTLIALCVYFRRDIAYLISDAITGLREGFGSQTSRLPFFIIAGTVPAAIAGKTLEKPIEEFFRGSHTLIALLLIAFGLLLALADTTGPKRWRMDRVDLRGALLIGLAQCLALIPGVSRSGITITAALFLGFTRDTAARFSFLLSLPIVAGAGILKMGELARHGIPAGELAPLLAGMATSAVSGYLGVALLLRLVQRYSLYPFVWYRLLAGGAVLAYLFAR
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTMR3_HUMAN
Sequence: MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
What is the function of this protein?
Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921).  Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11676921).  May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).
What are the official names of this protein?
Myotubularin-related protein 3, FYVE domain-containing dual specificity protein phosphatase 1, FYVE-DSP1, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, Zinc finger FYVE domain-containing protein 10.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: MIS12_PONAB
Sequence: MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQIRKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVSLVQNSRKLQNIRDNVEKESKRLKIS
What is the function of this protein?
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis.  Essential for proper kinetochore microtubule attachments.
What are the official names of this protein?
Protein MIS12 homolog.
What is the protein family that this protein belongs to?
Belongs to the mis12 family.
Protein: GATA_COXB2
Sequence: MHQKTIAELKQDLRDKTISSVELTQHFLDRIKTINPTLNSFISITEEYALTQAKAADARLAKGEATSLTGIPIAQKDIFCTKDIKTSCGSKMLDNFIAPYDATVVEQLNKAGAILIGKTNMDEFAMGSSNENSYFGAVKNPWDLERVPGGSSGGSAAAVAARLVPGATGTDTGGSIRQPAALCGITGLKPTYGRVSRYGMIAFASSLDQAGPMAQTAEDAALLLNALAGHDAKDSTSINKNVPDYTATLTTSLEGLKVGLPKEYFGEGLNSSIAESIETVKKTLEKMGATFIEIQLPHTDFAAPAYYVLAPAECSSNLARYDGVRYGYRCDKPVDLDDLYKRSRTEGFGSEVKRRIMIGTYVLSAGYYDAYYLKAQKIRRLIRDDFMKAFETVDVILTPATPTPAFKLNEKIADPVAMYLSDVYTIAVNLAGLPAIAFPAGFMDQLPIGAQLIGNYFEEARLLNITHRYQQETDWHKQSPKLR
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: SSRP_STRP6
Sequence: MAKGEGHILAQNKKARHDYHIVETVEAGIVLTGTEIKSVRAARIQLKDGFAQIKNGEAWLVNVHIAPFEQGNIWNADPERTRKLLLKKREITHLANELKGSGMTLVPLKVYLKDGFAKVLIGLAKGKHEYDKRETIKRRDQERDIKKQMKHYNAR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CAPSD_PMMVI
Sequence: MAYTVTSANQLVYLGSVWADPLELQNLCTSALGNQFQTQQARTTVQQQFSDVWKTIPTATVRFPATGFKVFRYNAVLDSLVSALLGAFDTRNRIIEVENPQNPTTAETLDATRRVDDATVAIRASISNLMNELVRGTGNYNQALFESVSGLTWATTP
What is the function of this protein?
Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: HTR5B_HUMAN
Sequence: MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTDVKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNKDDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSLQKVLSGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELENIATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMATGFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHVLDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAVEAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIVTSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAMAALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLGPSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAHCPELLTEDVIRKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPPKTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIEDQLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYKHRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTLVMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSLALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRGYVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLVGCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVACLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITETGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMSTATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLCENADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESKPKRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALLTLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESTEAAAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEHVTACLQALHTLLDSPYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQIVRAAQDYLQEKRNTLNEDDMEKEACTVLGEGGDSGGLIPGKSLVFATMELLMFILVRHMPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFLIARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACILEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQNGCMNRFKNALNSCDPWVQAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKVLETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSASKDLHEFALQNLMHIGPLYPHAFKTVMGAAPELKVRLETAVRASQASKAKAAARQPAPAIHSAPTIKLKTSFF
What is the function of this protein?
Component of clathrin-coated vesicles (PubMed:15758025).  Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025).
What are the official names of this protein?
HEAT repeat-containing protein 5B.
What is the protein family that this protein belongs to?
Belongs to the HEATR5 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Localization at clathrin- coated vesicles depends on AFTPH/aftiphilin.
Protein: KCD16_HUMAN
Sequence: MALSGNCSRYYPREQGSAVPNSFPEVVELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRLKREAEYFQLPDLVKLLTPDEIKQSPDEFCHSDFEDASQGSDTRICPPSSLLPADRKWGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDMLSECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVFYREPSRWSPSHCDCCCKNGKGDKEGESGTSCNDLSTSSCDSQSEASSPQETVICGPVTRQTNIQTLDRPIKKGPVQLIQQSEMRRKSDLLRTLTSGSRESNMSSKKKAVKEKLSIEEELEKCIQDFLKIKIPDRFPERKHPWQSELLRKYHL
What is the function of this protein?
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response.  Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD16, Potassium channel tetramerization domain-containing protein 16.
What are the subcellular locations of this protein?
Presynaptic cell membrane. Postsynaptic cell membrane.
Protein: ALFC7_ARATH
Sequence: MSAFVSKYEDELIKTAKYIATPGRGILAADESTETIGKRFAGINVENTESNRQAYRELLFTSPGSYPCLSGVILFEETLYQKTSDGKPFVDLLMENGVIPGIKVDKGLVDLAGTNGETTTQGLDSLGARCQQYYEAGARFAKWRAFFKIGATEPSVLSIQEDARVLARYAIICQENGLVPIVEPEVLTGGSHDIKKCAAVTETVLAAVFKALNYHHVLLEGTLLKPNMVTPGSDSPKVAPELIAEYTVTALRRTVPPAIPGIVFLSGIQREEQATLNLNAMNKLDVLKPWTLTFSFGGALQQSAIKAWAGKPENVAKAQAKFLTRCKANKDATLGKYTGWASGDSAAFENLVVIGYRY
What is the function of this protein?
Plays a key role in glycolysis and gluconeogenesis.
What are the official names of this protein?
Fructose-bisphosphate aldolase 7, cytosolic, AtFBA7.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: YE17_YEAST
Sequence: MLIDQIVAAVPGVPDISGNASALSLQRRSQEFATSWISMTYSQSYGDLAQNWQNDEGGAGNFDSYAEEKLQNFFSGNRDWKYCFAAEDTKNGEPLDYDDIPGDGAGTGSAFKSEIYFNTYGGIDNYCNDEHIGAQNTGDGR
What are the official names of this protein?
Uncharacterized protein YER187W.
What is the protein family that this protein belongs to?
To yeast killer toxin KHS and to YGL262w.
Protein: P3_HUMAN
Sequence: MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSIHSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP
What is the function of this protein?
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
What are the official names of this protein?
P3 protein, Solute carrier family 10 member 3.
What is the protein family that this protein belongs to?
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PLD5_HUMAN
Sequence: MEIRQHEWLSASPHEGFEQMRLKSRPKEPSPSLTRVGANFYSSVKQQDYSASVWLRRKDKLEHSQQKCIVIFALVCCFAILVALIFSAVDIMGEDEDGLSEKNCQNKCRIALVENIPEGLNYSENAPFHLSLFQGWMNLLNMAKKSVDIVSSHWDLNHTHPSACQGQRLFEKLLQLTSQNIEIKLVSDVTADSKVLEALKLKGAEVTYMNMTAYNKGRLQSSFWIVDKQHVYIGSAGLDWQSLGQMKELGVIFYNCSCLVLDLQRIFALYSSLKFKSRVPQTWSKRLYGVYDNEKKLQLQLNETKSQAFVSNSPKLFCPKNRSFDIDAIYSVIDDAKQYVYIAVMDYLPISSTSTKRTYWPDLDAKIREALVLRSVRVRLLLSFWKETDPLTFNFISSLKAICTEIANCSLKVKFFDLERENACATKEQKNHTFPRLNRNKYMVTDGAAYIGNFDWVGNDFTQNAGTGLVINQADVRNNRSIIKQLKDVFERDWYSPYAKTLQPTKQPNCSSLFKLKPLSNKTATDDTGGKDPRNV
What are the official names of this protein?
Inactive phospholipase D5, Inactive PLD 5, Inactive choline phosphatase 5, Inactive phosphatidylcholine-hydrolyzing phospholipase D5, PLDc.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MVD_GANLU
Sequence: MSVYQATASAPVNIACIKYWGKRDTKLILPTNSSLSVTLDQDHLRSTTTARADPSFQKDRLWLNGTEDEIKDGGRLATCIKEMKALRKQLEDKDASLPKISSYSVHISSRNNFPTAAGLASSASGFAALVASLAALYKLPTSQSDLSRIARQGSGSACRSLFGGFVAWQMGELPDGSDSLAVEIAPREHWPDIHALICVVNDEKKGTSSTAGMQRTVETSPLLQHRIKHVVPARMAAISAAIRTRDFDAFARITMQDSNQFHAVALDTEPPIFYMNDVSRAIIALIVEYNRVAVEKTGKLKAAYTYDAGPNAVIYTPKEHIKEIVELIVKYFPQAENFKDPFGLFGAAGVQGKVVDGFNEAVSKPFGVGAVKGLIHTRVGDGPRTLGPEEALLSPDGLPK
What is the function of this protein?
Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity).  The second module involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins (By similarity).  This module also plays a key role in the biosynthesis of triterpenes such as ganoderic acids (GA), a group of highly oxygenated lanostane-type triterpenoids which are well recognized as a main group of unique bioactive compounds in the medicinal mushroom Ganoderma lucidum (PubMed:22203490, PubMed:29476632).  Activity by the mevalonate kinase first converts mevalonate into 5-phosphomevalonate (By similarity).  5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase (By similarity).  The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate (PubMed:22203490).  The isopentenyl-diphosphate delta-isomerase then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity).  Finally the farnesyl diphosphate synthase FPS catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:18540102).
What are the official names of this protein?
Diphosphomevalonate decarboxylase, Mevalonate pyrophosphate decarboxylase, MPD, Mevalonate-5-diphosphate decarboxylase, MDD, MDDase.
What is the protein family that this protein belongs to?
Belongs to the diphosphomevalonate decarboxylase family.
Protein: ZAPD_ECOLI
Sequence: MQTQVLFEHPLNEKMRTWLRIEFLIQQLTVNLPIVDHAGALHFFRNVSELLDVFERGEVRTELLKELDRQQRKLQTWIGVPGVDQSRIEALIQQLKAAGSVLISAPRIGQFLREDRLIALVRQRLSIPGGCCSFDLPTLHIWLHLPQAQRDSQVETWIASLNPLTQALTMVLDLIRQSAPFRKQTSLNGFYQDNGGDADLLRLNLSLDSQLYPQISGHKSRFAIRFMPLDTENGQVPERLDFELACC
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ- dependent manner. Localization does not require FtsA, ZipA, ZapA or ZapC.
Protein: LPXC_SHEB5
Sequence: MIFQRTVQKMVKTTGVGLHSGNKVTLSIMPAPVNSGIVLVRTDLSPAVAIPAKAEQVRETTMCTALVNDEGIRISTIEHLFAALAGLGIDNAVIEVDAPEIPIMDGSASPFVFLLQSAGIKEQAAPKKYLKIKRPVRVEDGDKWAELKPFKGFRVNFKIDFAHPEIARSQQHVVMDFSTSAFVKDISRARTFGFMRDIEYLRANNLALGGSMENAVVLDEYRVLNPDGLRYEDEFVKHKILDAFGDLYVAGHAILGEFTAYKTGHALNNQLVRALLAQQDAWELVSFEKEADVPVSFTVPGGAVFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.