PharMolix/UniProtQA huggingface dataset:
Protein: BZZ1_SCHPO
Sequence: MSLETYKFSDELHDDFKVVDSWINNGAKWLEDIQLYYKERSSIEKEYAQKLASLSNKYGEKKSRKSSALSVGDTPAMSAGSLECASLTTWSKILDELTRSSKTHQKLSDDYSLDIAEKLKKLESHIEALRKVYDDLYKKFSSEKETLLNSVKRAKVSYHEACDDLESARQKNDKYREQKTQRNLKLSESDMLDKKNKYLLRMLVYNAHKQKFYNETLPTLLNHMQVLNEYRVSNLNEIWCNSFSIEKSLHDTLSQRTVEIQSEIAKNEPVLDSAMFGRHNSKNWALPADLHFEPSPIWHDTDALVVDGSCKNYLRNLLVHSKNDLGKQKGELVSLDSQLEGLRVDDPNSANQSFESKKASINLEGKELMVKARIEDLEVRINKITSVANNLEEGGRFHDFKHVSFKLPTSCSYCREIIWGLSKRGCVCKNCGFKCHARCELLVPANCKNGEPEVADDDAVDTSVTATDDFDASASSSNAYESYRNTYTDDMDSSSIYQTSLSNVKTEETTPAEPASKVDGVVLYDFTGEHEGVITASEGQEFTLLEPDDGSGWVRVKIDGTDGLIPASYVKLNDELNTSVTLDGDSSYVKALYAYTAQSDMELSIQEGDIIQVTNRNAGNGWSEGILNGVTGQFPANYVTDV
What is the function of this protein?
Plays a role in endocytosis and trafficking to the vacuole.  Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress (By similarity).
What are the official names of this protein?
Protein BZZ1.
What is the protein family that this protein belongs to?
Belongs to the BZZ1 family.
What are the subcellular locations of this protein?
Cell septum. Cell tip. Cytoplasm, cytoskeleton, actin patch.
Protein: VMP_NEMVE
Sequence: MKGFIFAGVLVSALICLAEGKPFDNLELVEDDMLMTKEQKEAYLAHQNGRVRRAALRDRYLWPQGKIPYTFSDDIDQAGRELAERAMNHWMSRTCLRFSPRRREHAYIEFQYDGRCRARVGYTGEARQKVSIGSALDPCPLGSVIHELGHGIGFFHEHSRPDRDEYVNINVNNMREGAESNFRKDNGYFVDSRGQDYDYGSIMHYSKYQGNNAFNAVVMEPIQRGAEIGQRDGLSAGDIRQTNLMYKCNAQGDSELQPVNDEDEDKDGGDSKKKPDPKGPKPGEIEE
What is the function of this protein?
Metalloprotease.
What are the official names of this protein?
Nematocyst expressed protein 6, NEP-6, NEP6, Astacin-like metalloprotease toxin.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: YPQQ_KLEPN
Sequence: SVPGDPIDILWQQLAILKQLIAHSAGRLRLCLSAADIERCREDKVLAMVAHIEGAGGFDGEGRDLQAFYAAGVRSIGPFWNIANRFGSGVNGSFPGSPDTGPGLTAAGIDLIKQVNALKMQIDVSHMNEKAFWDTAHHATSPLVATHSNAHALCPQPRNLTDQQLRAIRDSGGVVGVNFGNAFLRADGRRDSDTPLTTIVRHIDYLINIMGEDHVALGSDFDGITLPDELGDVAGLPRLINTLRASGYDQLVLDKLLWRNWLRVLKNVWQQ
What are the official names of this protein?
Uncharacterized protein in pqqA 5'region, ORF X.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Protein: HDA_SALAR
Sequence: MQSWVEVSLNTPAQLSLPLYLPDDETFASFWPGDNASLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECVAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDHASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: PSAA_COFAR
Sequence: MIIRSPEPEVKILVDRDPVKTSFEEWAKPGHFSRTIAKGPDTTTWIWNLHADAHDFDSHTSDLEEISRKVFSAHFGQLSIIFLWLSGMYFHGARFSNYEAWLSDPTHIGPSAQVVWPIVGQEILNGDVGGGFRGIQITSGFFQIWRASGITNELQLYCTAIGALIFAALMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWAGHQVHVSLPINQFLNAGVDPKEIPLPHEFILNRDLLAQLYPSFAEGATPFFTLNWSKYAEFLTFRGGLDPVTGGLWLTDIAHHHLAIAILFLIAGHMYRTNWGIGHGLKDILEAHKGPFTGQGHKGLYEILTTSWHAQLSLNLAMLGSLTIVVAHHMYSMPPYPYLATDYGTQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTRYNDLLDRVLRHRDAIISHLNWACIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIQNTHALAPGATAPGATASTSLTWGGGDLVAVGGKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSISDQGVVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLFFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPATQPRALSIVQGRAVGVTHYLLGGIATTWAFFLARIIAVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NTPTH_ARCFU
Sequence: MKVAVTGRPGVGKTTLCLKVHESLKDKMTVGGFITKEVRRDGVRVGFKLVDLSSGNEEWLARVGEGKARVGKYAVNVEGLEEFLDSVRTDADLVIIDEVGPMELKSRKFVRFVENLMGRERLLFTIHLKSRHRLLDRIRREFKVYVIDESNRNRIAEEITRILEG
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: SYN_BACTN
Sequence: MEKIGRTKIVDLLKREDIGAMVNVKGWVRTRRGSKQVNFIALNDGSTINNVQIVVDLANFDEEMLKLITTGACISVNGVMVESVGSGQKVEVQAKEIEVLGTCDNTYPLQKKGHSMEFLREIAHLRPRTNTFGAVFRIRHNMAIAIHKFFHEKGFFYFHTPIITGSDCEGAGQMFQVTTMNLYDLKKDERGSISYDDDFFGKQASLTVSGQLEGELAATALGAIYTFGPTFRAENSNTPRHLAEFWMIEPEVAFNDIADNMDLAEEFIKYCVKWALDNCADDVKFLNDMFDKGLIERLQGVLKDDFVRLPYTDGIKILEDAVAKGHKFEFPVYWGVDLASEHERYLVEEHFKRPVILTDYPKEIKAFYMKQNEDGKTVRAMDVLFPKIGEIIGGSEREADYNKLMTRIEEMHIPMKDMWWYLDTRKFGTCPHSGFGLGFERLLLFVTGMSNIRDVIPFPRTPRNADF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDH_SALTY
Sequence: MKKTGYFLLAVIVIVAAAGVGYWKFSGNPDALREIVLEQCLPDQLQHQNPAPCAEVKPRAGYVVFKDRHGPLQYLLMPTYRINGTESPLLLEPATPNFFWLAWQARGYMSKKYGHDIPDSAVSLAINSRLGRSQDHLHIHISCIRPDVREQLDNDLTRISTRWLPLPGGLMGHEYLARRVTESELAQRSPFMMLAEEVPEARDHMGRYALAVVRQSDDSFVLLATERNLLTFNRASAEEIQDHSCAILSSR
What are the official names of this protein?
CDP-diacylglycerol pyrophosphatase, CDP-diacylglycerol phosphatidylhydrolase, CDP-diglyceride hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Cdh family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CAT2_STAAU
Sequence: MTFNIIKLENWDRKEYFEHYFNQQTTYSITKEIDITLFKDMIKKKGYEIYPSLIYAIMEVVNKNKVFRTGINSENKLGYWDKLNPLYTVFNKQTEKFTNIWTESDNNFTSFYNNYKNDLLEYKDKEEMFPKKPIPENTIPISMIPWIDFSSFNLNIGNNSNFLLPIITIGKFYSENNKIYIPVALQLHHAVCDGYHASLFMNEFQDIIHKVDDWI
What is the function of this protein?
This enzyme is an effector of chloramphenicol resistance in bacteria.
What are the official names of this protein?
Chloramphenicol acetyltransferase, CAT.
What is the protein family that this protein belongs to?
Belongs to the chloramphenicol acetyltransferase family.
Protein: Y449_METJA
Sequence: MREVEKPLILSIVGNILLGLIKIIIGYVYSSISLISDGIHSLSDVITSIIGIIGVKIASKPPDESHPYGHSRFECLFSFFIGLALFFTAYEIGKFAVERIIYGEVIEVNAIMVGVAILSIVVKELMTRYSLFVGKKLNSQVLIADAYHHRSDALSSVVVLVGLLLQKFGIYYGDAIAGIIVALMIAKVAFDICLTNIDYLTGRAPPKKFFELIEKEALNVDKVIGVHDIKAHYVGPRIHVELHVEVPSNISAKEMHDIEVAVKNRLESLENVERAYVHVDIVD
What are the official names of this protein?
Uncharacterized transporter MJ0449.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GPDA_STRPI
Sequence: MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINTHHTNKHYFKDVVLDENIIAYTDLAETLKDVDAILFVVPTKVTRLVAQQVAQTLDHKVIIMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAEETIVRDLTLITAASKDLQTAQYVQELFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAIIARGLAEITRLGVALGASPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIEANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAENEWS
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI39_RAT
Sequence: MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQTVKRKIRDESLCSQHHEPLSLFCYEDQEAVCLICAISHTHRAHTVVPMDDATQEYKEKLQKCLEPLEQKLQEITCCKASEERKPGELKRLVESRRQQILKEFEELHRRLDEEQQTLLSRLEEEEQDILQRLRENAAHLGDRRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSHFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPQRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
What is the function of this protein?
E3 ubiquitin-protein ligase (By similarity).  May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity).  Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity).  Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM39, RING finger protein 23, RING-type E3 ubiquitin transferase TRIM39, Tripartite motif-containing protein 39.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion. Nucleus. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus.
Protein: KAD_THENE
Sequence: MMAYLVFLGPPGAGKGTYAKRIQEKTGIPHISTGDIFRDIVKKENDELGKKIKEIMEKGELVPDELVNEVVKRRLSEKDCEKGFILDGYPRTVAQAEFLDSFLESQNKQLTAAVLFDVPEDVVVQRLTSRRICPKCGRIYNMISLPPKEDELCDDCKVKLVQRDDDKEETVRHRYKVYLEKTQPVIDYYGKKGILKRVDGTIGIDNVVAEVLKIIGWSDK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_MYCVP
Sequence: MAIVNQPRTLAEKVWSDHVVVAGTGEGAAREPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTIATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGIRLHPMGDVEQGIVHIIGPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGQLPPGVSAKDIILAVIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAGMIAPDETTFEFLRGRPHAPKGAEWDAAVAVWRQLRTDEGAQFDTEIYIDASTLSPFVTWGTNPGQGVPLSDPVPDPELMFDEAERQAAEKALAYMDLRAGTPMRQIPVDTVFVGSCTNGRIEDLRVVADILRGRRVADNVRMLVVPGSMRVRAQAESEGLGEIFTAAGAEWRQAGCSMCLGMNPDQLAPGERCASTSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSSPADLAAEPTH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: TERC_ALCSP
Sequence: MVSTHIGGPAETVTVFVALSVGAIFIDLFMHRHDKPISLKSAALWSVFWVVVAMAFAGFLYVHHGAEVASLFVTGYALEKVLSVDNLFVMMAIFSWFSVPDRYRHRGLYWGIIGAIVFRGIFVAIGTGLLSLGPYVELIFAVVVAWTAVMMLKGGGDDDEIEDYSQHLAYRLVKRFFPIWPKLSGHAFLLTQKEVDAELAKPENKDVSVGRLKKAALYATPLMLCVAVVELSDVMFAFDSVPAIIAVSREPLIVYSAMMFAILGLRTLYFVLEALKQYLSQLEKAVIVLLFFIAFKLGLNATDHIWHHGYSLSATTSLYVVLGVLALGILASVIFPEKPEAENKES
What is the function of this protein?
Could conceivably alter the intracellular level of tellurium in a manner leading to resistance.  Alternatively its presence in the membrane may provide a barrier to entry of the tellurium ions.
What are the official names of this protein?
Tellurium resistance protein TerC.
What is the protein family that this protein belongs to?
Belongs to the TerC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MATP_ECOL5
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYIEASAAQEAVDELLSLENEPVLVNGWIDKHMNPELVNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFIVWHRLAGLAQRRGKTLSETIVQLIEDAENKEKYANKMSSLKQDLQALLGKE
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PATB_ASPCL
Sequence: MLFTASLLLLLPWASAAPANLPIVDLGYQRHQAISFNSTGQYYSFTNIRYAEPPLGSRRFAPPVAPHGRSKNIVNGTGLGYKCPQALACWFNVQNKFTSAAAAGTPFDFNAAYEEVYTKDACTEPAKQDPLQSEDCLFLDVYVPQDVWQKGPQAAHQKGGAPVLVYLQDGAYVGGSKSDQNPAGLIARSREEGSSGMIYVGINYRLGVFGWLSGRKFTSSGGKPNAGLLDQRLALEWIQRHIHLFGGDPSRVTVMGVSAGGGSIIMQMTAYGRGISPPFAQVITQSPAWEPGTKTPAIEDDLFDTFLASLNVTSLDQARRLPSHALTDANYRLVASRPYGAGVLGPAIDGDFIPDSPKRLLLQGKANPGVRVLTSYTAAEGFGIAPANITDEASFQRYVGLMLAGTDASVRTHAATVLYPAVFDGSMPYRTQHDRASLLWADLAASCNTRYLHAAVRTPGYAIEYSVPPALHLSDTPSVFYNGPVADPTVNGTIAELLQRQIVRFVKTGNPNGEPDPEVPVYDGRDLLDLGDDGVLVRPDSTDNARCEYWQKVHF
What is the function of this protein?
Carboxylesterase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (By similarity).  The function of patB in patulin synthesis has still to be characterized (By similarity).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units.  The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol).  These first reactions occur in the cytosol.  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI.  The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole.  PatN catalyzes then the transformation of isoepoxydon into phyllostine.  The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol.  The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM.  Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (PubMed:19383676) (Probable).
What are the official names of this protein?
Carboxylesterase patB, Patulin synthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RECQ1_HUMAN
Sequence: MASVSALTEELDSITSELHAVEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNISKCRRVLMAQHFDEVWNSEACNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTLPREDLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNSFRAESSQTCHSEQGDKKMEEKNSGNFQKKAANMLQQSGSKNTGAKKRKIDDA
What is the function of this protein?
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens.  Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
What are the official names of this protein?
ATP-dependent DNA helicase Q1, DNA helicase, RecQ-like type 1, RecQ1, DNA-dependent ATPase Q1, RecQ protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y2819_RHIWR
Sequence: MTGDKPFWETKRLDEMTRAEWESLCDGCGKCCLHKLEDEETGELMATNVACRLLDRRTGLCKDYKHRRTFVPECVRLTPRVLREIDWLPSTCAYRLLDEGQPLPDWHPLVSGDPESVHKAGVSVRGWTVSEDEAGDLEHHLVDRQL
What are the official names of this protein?
UPF0260 protein Swit_2819.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: RS8E_METS5
Sequence: MGVYQGRDLRKITGGKKNVSRGKRKFEIGSQPTETKVYSEDIREKARVLGGNAKVRLTYAAYANVINLSDGTAKKVKILEVIESSANREYARRGIIVKGSIIRTEIGKALVTSRPGQHGVINAILMQQ
What are the official names of this protein?
30S ribosomal protein S8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: HSCB_ACIBS
Sequence: MNHFELFNLPVALDIDLASLKSNFLSLQQQYHPDKAADKDQALIKSSEINQAFKTLSQVDSRAAYLLALKKQDHHLDQSISDFEFLQSALELREQLDEATSSEHLRTLRLEVQQWIDGLVREFKIDYSEEDWSEARDTVRKLRFFQRVLNDIDKAEDQLLDDEDSFDLDDDF
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: METE_SALHS
Sequence: MTILTHTLGFPRVGLRRELKKAQESYWAGNTTREALLAVGRELRARHWEQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVPARHQNNDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYIVPEFSKGQQFRLTWTQLLEEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDRLTLLKDILPVYQHVLAELAKRGIEWVQIDEPALVLELPQAWLDAFKPAYDALAGQVKLLLTTYFEGVTPNLDTIIALPVQGLHVDLIHGKDDVAELHQRLPVDWLLSAGLINGRNVWRADLTEKYAQINAIVGKRALWVASSCSLLHSPIDLSVETRLDTEVKSWFAFALQKCGELALLRDALNSGETAALEEWSAPIQARRHSRRVHNAAVEKRLAAITAQDSQRENPYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANHYRTGIAEHIKQAIIEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLEWGVEAFRINAAVAKDETQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPAQRLWVNPDCGLKTRGWPETRAALANMVKAAHNLRQAK
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: CAMP_CRODU
Sequence: MQGFFWKTWLVLAVCGTPASLAHRPLSYGEALELAVSVYNGKAGEASLYRLLEAVPQPEWDPSSEGSQQLNFTLKETACQVEEERSLEECGFQEDGVVLECTGYYFFGETPPVVVLSCVPVGGVEEEEEEEEEEQKAEAENDEEVEKEKGDEEKDQPKRVKRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF
What is the function of this protein?
Potent antimicrobial peptide against Gram-negative (P. aeruginosa, K. pneumoniae, E. coli, A. baumannii) (PubMed:25100358, PubMed:26465972).  Shows moderate activities against Gram-positive bacteria (E. faecalis, S. aureus, S. pyogenes) (PubMed:25100358, PubMed:26465972).  Also shows antifungal activity against standard and clinical isolates of yeasts (MIC=10-40 uM) and dermatophytes (MIC=1-5 uM) (PubMed:27876749).  Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane (PubMed:26465972).  Shows high toxicity towards human fibroblasts (micromolar ranges) (PubMed:26465972).  Shows low hemolytic activities on human erythrocytes (PubMed:25100358, PubMed:26465972).  Also shows toxicity (micromolar ranges) when tested on many leukemia cell lines (PubMed:26465972).  In addition, when tested in vitro on the parasite Trypanosoma cruzi (responsible of the Chagas disease), is able to reduce the number of the three forms (epimastigote, trypomastigote and amastigote) by inducing cell death through necrosis (PubMed:29208061).
What are the official names of this protein?
Crotalicidin, Ctn, Cathelicidin-related antimicrobial peptide, CRAMP, Vipericidin.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey (By similarity).
Protein: ZN16L_DANRE
Sequence: MSRKRNHCYMETGASSESQGAFVDSAGPFSRDEEDFSELEPDEQLVCSVTEITEHLGRNITVVLESALSEIRKLVGVRIRVLKMELREKSDEIELLKAKLESAEKDGRVSNFSSLDFRKSEHQKYGAEPKKAKTGTPVVKKENINAICDYLMKDKNQRGAAEVESDHSNQAFGSERDVRTEAQPHGSLSLWPDSGPADTDAETDIFSMLPSASKRMYDYEWMTGVELNSAEFKGDSETKCEDVPPMDEEDENEDSEEGRGSLRSVSDHFPLDTQGSPGEDRSSPAEDSMDRMEPGQQFTSHTFICPFCGTLCPDSSFLEEHIKLMHHGESLLQSTSAGSSSQAEGDSGEAGPASRGAREKKVEGGYECGDCGRHFNYLGNLRQHQRIHTGEKPFVCPECGERFRHTARLKSHRLSHSGAQSPFPCPQCGKGFPVLSGLKRHQRVHTGESPYACPQCGRRFKELGNLYTHMRIHSGATPYTCYQCGRSFRHLGTYKSHRCMPATQMPSEHSPPWAQEDKVQTGRLQGYV
What is the function of this protein?
Probable transcription factor (Probable).  Important for development and migration of oligodendrocyte precursor cells, and normal myelination of axons in the central nervous system (CNS) (PubMed:26459222).  Functions autonomously in oligodendrocytes to promote CNS myelination (PubMed:26459222).  Seems to act in parallel with notch3 during oligodendrocyte development (PubMed:26459222).
What are the official names of this protein?
Zinc finger protein 16-like, Zinc finger protein 697-like.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TM273_HUMAN
Sequence: MNLGVSMLRILFLLDVGGAQVLATGKTPGAEIDFKYALIGTAVGVAISAGFLALKICMIRRHLFDDDSSDLKSTPGGLSDTIPLKKRAPRRNHNFSKRDAQVIEL
What are the official names of this protein?
Transmembrane protein 273.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ABP1_TOBAC
Sequence: MARHVLVVVAVLLFATAEASQCSINGLPLVRNISELPQENYGRSGLSHTTIAGSVLHGMKEIEVWLQTFAPGSRTPIHRHSCEEIFVVLKGQGILYLTPSSHSKYPGNPQEFHIFPNSTFHIPVNDVHQVWNTGEHEDLQVLVVISRPPVKVFMYDDWSMPHTAAKLKFPYYWDEECYQTTSWKDEL
What is the function of this protein?
This is probably a receptor for the plant hormone auxin.
What are the official names of this protein?
Auxin-binding protein T85, ABP.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: TRPG1_HALMA
Sequence: MSTAQPAGADAVRDDLRVLFVDNFDSFTYNLVEYVSEHAETEVVRNTASLDDVEAFDPDAIILSPGPGHPKNERDVGVTLDVLREVSPDVPTLGVCLGLESAVYAYGGTIGRAPEPIHGKAFPIDHDGKGVFAGLEQGFQGGRYHSLIADDVPEEFVVSATTETEDGTELVMGVRHREHPIEAVQFHPESVLTAVGHDVIRNFLAGL
What are the official names of this protein?
Anthranilate synthase component II.
Protein: Y096_OSHVF
Sequence: MANYDSNECVVCMEEKPLVVFEPCMHHNCCESCSGHVSNCPYCRADITGVYLEASVKVKLEPCEHIVKLIKITEKKCSTCDQDTTGMVIVDGKLTKTFKAENYRNAARLKNIIAMLIKAAKARNNRPGFFRKMKFGIPSVFTNYIHLDSCVICKKEIKEEVGKTYMHACCTATICKPCAKAILKAMVEKEITENLPFCPYCFTKTPIKYGLNAEGELLDPPSDSFSYYYVNEYMKMINNQ
What are the official names of this protein?
Putative RING finger protein ORF96.