PharMolix/UniProtQA huggingface dataset:
Protein: KRA91_HUMAN
Sequence: MTHCCSPCCQPTCCRTTCCRTTCWKPTTVTTCSSTPCCQPSCCVPSCCQPCCHPTCCQNTCCRTTCCQPTCVASCCQPSCCSTPCCQPTCCGSSCCGQTSCGSSCCQPICGSSCCQPCCHPTCYQTICFRTTCCQPTCCQPTCCRNTSCQPTCCGSSCCQPCCHPTCCQTICRSTCCQPSCVTRCCSTPCCQPTCGGSSCCSQTCNESSYCLPCCRPTCCQTTCYRTTCCRPSCCCSPCCVSSCCQPSCC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
What are the official names of this protein?
Keratin-associated protein 9-1, Keratin-associated protein 9-like 3.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 9 family.
Protein: RAB26_MOUSE
Sequence: MSRKKTPKSKGGSEPATSTLPAAAAATNGPRLAHPRTVRPGPEAPPNGPPQSIRPSLGSTGDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGMKVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDITNKDSFDNIQAWLTEIQEYAQQDVVLMLLGNKVDSTQDRVVKREDGEKLAKEYGLPFMETSARTGLNVDLAFTAIAKELKQRSAKAPSEPRFRLHDYVKREGRGVSCCRL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane.  Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity).  Plays a role in the secretion of amylase from acinar granules in the parotid gland.
What are the official names of this protein?
Ras-related protein Rab-26.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location.
Protein: SNPC3_HUMAN
Sequence: MAEGSRGGPTCSGVGGRQDPVSGSGGCNFPEYELPELNTRAFHVGAFGELWRGRLRGAGDLSLREPPASALPGSQAADSDREDAAVARDLDCSLEAAAELRAVCGLDKLKCLEDGEDPEVIPENTDLVTLGVRKRFLEHREETITIDRACRQETFVYEMESHAIGKKPENSADMIEEGELILSVNILYPVIFHKHKEHKPYQTMLVLGSQKLTQLRDSIRCVSDLQIGGEFSNTPDQAPEHISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGKFQTARMEDFTFNDLCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDCLDRTLYPLLIKKHWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKLGEFLAYPYVDPGTFN
What is the function of this protein?
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes.  Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes.  Recruits TBP and BRF2 to the U6 snRNA TATA box.
What are the official names of this protein?
snRNA-activating protein complex subunit 3, SNAPc subunit 3, Proximal sequence element-binding transcription factor subunit beta, PSE-binding factor subunit beta, PTF subunit beta, Small nuclear RNA-activating complex polypeptide 3, snRNA-activating protein complex 50 kDa subunit, SNAPc 50 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the SNAPC3/SRD2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACYP_VIBC3
Sequence: MEKQCSKFIVSGHVQGVGFCYHTSHQGLKLGLTGYAKNLNNGDVEVVACGTPERLEELYLWLQEGPKTASVRQVRRLSSELEHDYQGFEIL
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: PYG_SYNY3
Sequence: MALPLLNYAPKSQNVRVEGYEIGSEEKPVVFTTENILSSSDMDNLIEAAYRQIFFHAFKWDREKVLESQLRNGQITVRDFVRGLLLSNTFRNSFYEKNSNYRFVEHCVQKILGRDVYSEREKIAWSIVVATKGYQGLIDDLLNSDEYLNNFGYDTVPYQRRRNLPGREAGELPFNIKSPRYDAYHRRQLGFPQIVWQNEVRRFIPQEKKLTAGNPMNFLGMARSINPAANTIPKVSAQNINIEASVPRR
What is the function of this protein?
Rod-core linker protein required for attachment of rods with the core of the major allophycocyanins in phycobilisomes, plays a major role in light harvesting.  Although able to transfer energy to both photosystems, this is predominantly a PSII antenna (PubMed:16049785, PubMed:17468217, PubMed:19152018).  Involved in state transitions (PubMed:19152018).
What are the official names of this protein?
Phycobilisome rod-core linker polypeptide CpcG.
What is the protein family that this protein belongs to?
Belongs to the phycobilisome linker protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=The phycobilisome supercomplex detaches from the thylakoid easily.
Protein: BGAL_LACHE
Sequence: MQANINWLDNPEVFRVNQLPAHSDHPFFRDYREWQKQHSSYQQSLNGKWKFHFSANPMDRPQDFYQRDFDSSNFDSIPVPSEIELSNYTQNQYINVLFPWEGKIFRRPAYALDPNDHEEGSFSKGADNTVGSYLKRFDLSSALIGKDVHIKFEGVEQAMYVWLNGHFVGYAEDSFTPSEFDLTPYIQDKDNLLAVEVFKHSTASWLEDQDMFRFSGIFRSVELLGIPATHLMDMDLKPRVADNYQDGIFNLKLHFIGKKAGSFHLLVKDIKGHTLLEKNEDIKENVQINNEKFENVHLWNNHDPYLYQLLIEVYDEQQNLLELIPFQFGFRRIEISPEKVVLLNGKRLIINGVNRHEWDAKRGRSITMSDMTTDINTFKENNINAVRTCHYPNQIPWYYLCDQNGIYVMAENNLESHGTWQKMGEIEPSDNVPGSIPQWKEAVIDRARINYETFKNHTSILFWSLGNESYAGDNIIAMNEFYKSHDDTRLVHYEGVVHRPELKDKISDVESCMYLPPKKVEEYLQNDPPKPFMECEYMHDMGNSDGGMGSYIKLLDKYPQYFGGFIWDFIDQALLVHDEISGHDVLRYGGDFDDRHSDYEFSGDGLMFADRTPKPAMQEVRYYYGLHK
What are the official names of this protein?
Beta-galactosidase large subunit, Beta-gal large subunit, Lactase large subunit.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: CSPL8_POPTR
Sequence: MEKKDEGNPPMAVMGSRDENEDVKSTMRTAETMLRLVPVALCVSALVVMLKNTQTNDYGSLSYSDLGAFRYLVNANGICAGYSLLSAVIVAMPRAWTMPQAWTFFLLDQVLTYVILAAGTVSTEVLYLANKGDTSIAWSAACASFGGFCHKALISTVITFVAVIFYAALSLVSSYKLFSKYDAPVVTQSGEGIKTVTLGSPPPPPPPPPSNLHLHLHAKLACPAHNNSPN
What are the official names of this protein?
CASP-like protein 2A2, PtCASPL2A2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EIF3H_DROER
Sequence: MANRANRHAARTEDSDNTINYVQCDGLAVMKMVKHCHEESSNMDLAQGALLGLVVDKCLEITNCFPFPKSGDETMDEELYQLTVMRRLRRVNVDHLHVGWYQSSDVGNSLSLALLESQYHYQTSIEESVVVVYDTQKSSRGFLCLKAYRLTPQAIQMYKDGDFTPEAFRTLKVGYESLFAEIPIVIKNSPLTNIMMSELNELLPEDKGHNFLDLGTATVLENQMRSLIERVDELYQEAVRYNKYQQVVFKQDTEKHRALAKLAAENAVRTSKGEPTVPEEEVIKQFRPMTAPNRLTATITSGQINTHAQHIAQFCSQSLAKLFITESLQNAKEAKETK
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit H, eIF3h, Eukaryotic translation initiation factor 3 subunit 3.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP6B_METJA
Sequence: MVGFMGDELFKEFKEHSVAEFFRKNKHMLGYSGKIRSLTTIIHELVTNSLDACEEAGILPDIKVEIEKLGADHYKVAVEDNGPGIPLEFIPKVFGKMLAGSKMHRFIQSRGQQGIGAAGVLLFSQITTGKPLKIITSTGDGNIYEVEVKMNVEKNEGEIVSKKVRKGKWRGTRVEGEFKEVSYNRGEFGPFEYLRRISLATPHAKIVLKDPYGEVVFDRVVNELPKKPEEMKPHPYGLTTDELLYIARKTKSKKVSSMLVSELSRVTTKRIKELINYMLRDLILKKFKDSVFWNMVVSCYLNIDIESYLNKFKDYITDDEIETVRMLIKNLPESLDELKRYALKYITMEYLFNKLSEEEINKLKNHFKKIPENFMEWAEKNYLSATVVDELNKKVKNIVKNPEEFIAEIKNKGLISDEELKKFEDEVKSILNKNPKELTWDEAEMIVNCLQSMEFMAPPTTGLRPIGAENIEKSLKELLQPDFVKAITRNPKTYKGGIPFAVEVAIAYGGNAGRQGDEGRRMEIMRFANHVPLLYDASACGLTKAVKSINWKRYGLRGEDAPITVFVNLISTFIPYTSAGKQAVACSENENEEIYNEIRHALMICGRELEKYLSRIRREAEEEKKRKYVMKYARIFAEALANILNKPVDEIEEKVVKLLE
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit B, TopoVI-B.
What is the protein family that this protein belongs to?
Belongs to the TOP6B family.
Protein: VE2_HPV15
Sequence: MVILLQSLQKSAYGKEPWTLTQTSLETVRSAPANCFKKGPQNIEVMFDKDPENIMVYTVWTYIYYQTLDDTWNKVEGKIDYHGAYYLEGTLKVYYIQFEVDAARFGKTGIWEVHVNEDTIFAPVTSSSPAAGEGATSIDSAPESPANRQLSSTSVSSRKRTPPRTEARRYNRKESSPTTTTTRRQKRQGQRQEDTARRSRSTSRGRQEISRGGNQRRRRRSRETSISPAWGRGGRSRRGPTTRSQSKSLSRSRSRSKSRSRGSSPRGGISPADVGSSVRSLGRKHTGRLERLLEEARDPPVILLRGDANKLKCFRFRAKKKYQDLVKYYSTTWSWVGGTSNDRIGRSRLLLAFSSNTERELFIKIMKLPPGVDWSLGYLDDL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RBFA_METPP
Sequence: MKHKRAIPNRGLRVADQIQRDVAGLIRELKDPRIGMVTIQAVEVTPDYAHAKVFFSVLIGDPAECAAALNEAAGYLRNSLFKRLQIHTVPTLHFQFDRTTERAADLNALIHQANATRAKDADDQPGATEA
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_CHLMU
Sequence: MKKNTHPEYRQVLFVDSSTGYKFVCGSTYQTDKTEVFEGQEYPVCYVSVSSSSHPFFTGSKKLVDAEGRVDKFLKRYSGVKQMAPKPETSVEEVLPKGKKKAPAKKKK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: PA2AI_TRIST
Sequence: SLIQFETLIMKVAKKSGMFSYSAYGCYCGWGGQGQPQDPTDRCCFVHDCCYGKVTGCDPKMDIYTYSEENGDIVCGGDDPCRKAVCECDKAAAICFRDNKDTYDWKKYWRFPTKNCQESVPC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows a moderate inhibition of ADP-induced human platelet aggregation when tested on platelet rich plasma.  Exhibits moderate hydrolytic activities and prefers the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 CTs-A3, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPG_MYCLE
Sequence: MAATLRELRGRIRSVGSIKKITKAQELIATSRIARAQVRLESARPYAVDITRMLTTLAYEAVLDHPLLVASATPKRAGVLVVSSDRGLCGAYNANVFRRSEELFSLLRAEGKTPILYVVGRKALNYYTFRNWGIAESWTGFSEQPKYENAAKIASTLVDVFMLGSSESDAGVDELHIVFTEFKSMLSQSTKARRMAPMVVEYVEESKLPRTLYSFEPDATTLFEALLPRYLTIRVYAAMLESAASELASRQRAMKSATDNADDLIKALTLEANRERQAQITQEISEIVGGANALANAR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RECF_STRSV
Sequence: MWLQSLKIKHFRNYQEADIDFHPGLNVFLGQNAQGKTNILEAIYFLALTRSHRTRSDKDLIHFTENDLLVSGILEKKTGKVPLDINLTPKGRITKVNHLKQSKLSDYIGTMNVVLFAPEDIQLIKGSPSLRRKFIDIELGQIKPVYLSDLSNYNHVLKQRNAYLKANDKVDETFLTVLDEQLVDYGCRVIRHRLDFLQKLESFAQDKHWDISQNLEKLTVKYLSSIPLHQIDNLEETYRFSLIISRKRDLFKKNTGVGPHRDDIAFFINQMDANFGSQGQHRSLVLSLKLAEIKLIESITKETPILLLDDVMSELDNSRQLKLLETISQDIQTFITTTTLEHLKNLPQDIKIFTIQQGQIMSQS
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYN_NOSS1
Sequence: MVNRRIAEILRSGQPDESLVVQGWVRTKRELKGFAFIEVNDGSSLGNLQVVINQDLPDYAVIVKQLNTGASVEVNGVLVASQGKGQRIELKAEAVKVYGEADPETYPLQKKRHSFEFLRTIGHLRSRTNSFGAVFRVRNACSAAIHQFFQERGFLWVHTPIITASDCEGAGELFSVTSLDLKQIPRTENQGIDYSQDFFAKPTYLTVSGQLEAEVMAMAFSNVYTFGPTFRAENSNTSRHLAEFWMVEPEMAFCDLEGDMDLAEAFLKHIFNHVLEKCPEDMEFFNQRIDNTVLATAENIINNQFERLTYTDAIKLLEKADVKFEYPVSWGLDLQSEHERYLAEQLFKKPVIVTDYPAQIKAFYMRLSDDEKTVRAMDVLAPKIGEIIGGSQREERLDVLERRVLAQGMQPEDLWWYLDLRRYGTVPHAGFGLGFERLVQFITGMGNIRDVIPFPRTPQNAEF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_ROSS1
Sequence: MSSDLKRRSRTITDGRTRAGARAMLKAIGFTDEDLAKPIIGIANTWIETMPCNINLRALAARVKEGVRAAGGTPMEFNTVAIADGVTMGTEGMKASLISRDLIADSIELMGRGYMFDAIIALVACDKTIPGAAMGLTRLNIPGFLLYGGSIAPGHWRGKEITIQHVYEAIGAVAAGKMTDEELKEIEDAACPGPGACGGQYTANTMATVMEIIGLSPMGTAAVPAADPRKDSVGYRAGQLIMDVLRRDLKPRDILTRAAFENAIASVALTGGSTNAVLHLLALAREAGVPLTLDDFDAISRRTPLCCDLMPSGKYSAIHVDQAGGIQVIARRLVDGGFAHGDAITVTGRTLAEEAADAVETPGQDVIRPLDNPIKPTGGLLVLRGNLAPEGSVVKLFGYERTYHRGPARVFDGEEAAMAAIVGGEIRPDDIVIIRYEGPRGGPGMREMLGVTSAIVGAGLGQSVSLITDGRFSGATRGVMIGHVAPEAARGGPLAIVQEGDEIEINLDERRVDLLLSEEEIADRLLAWQPPAPRYEWGVMARYGALVSSASEGAVLVTP
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: MT21D_HUMAN
Sequence: MADTLESSLEDPLRSFVRVLEKRDGTVLRLQQYSSGGVGCVVWDAAIVLSKYLETPEFSGDGAHALSRRSVLELGSGTGAVGLMAATLGADVVVTDLEELQDLLKMNINMNKHLVTGSVQAKVLKWGEEIEGFPSPPDFILMADCIYYEESLEPLLKTLKDISGFETCIICCYEQRTMGKNPEIEKKYFELLQLDFDFEKIPLEKHDEEYRSEDIHIIYIRKKKSKFPS
What is the function of this protein?
Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.
What are the official names of this protein?
Protein N-lysine methyltransferase METTL21D, Methyltransferase-like protein 21D, VCP lysine methyltransferase, VCP-KMT, Valosin-containing protein lysine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL21 family.
Protein: DCD_GRABC
Sequence: MSIMPDHWIRQMATGHGMIEPFVETQKRDGVISYGLSSYGYDARVADEFKIFTNVDSAVVDPKAFSPASFVDRKGPVCIIPPNSFALAHTVEYFRIPRNVLVICLGKSTYARCGIIVNVTPLEPEWEGQVTIEISNTTPLPARIYAGEGICQFLFLRGDSDCETSYADKAGKYMGQRGVSLPRM
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: GPA1_LOTJA
Sequence: MGLLCSKNRRYNDADTEENTQTAEIERRIELETKAEKHIQKLLLLGAGESGKSTIFKQIKLLFQTGFDEAELKSYQPVIHANVYQTIKLLHDGAKELAQNDVDFSKYVISDENKEIGEKLSEIGGRLDYPCLTKELALEIENLWKDAAIQETYARGNELQVPDCTHYFMENLHRLSDANYVPTKDDVLYARVRTTGVVEIQFSPVGENKKSGEVYRLFDVGGQRNERRKWIHLFEGVSAVIFCAAISEYDQTLFEDENKNRMMETKELFEWVLKQPCFEKTSFMLFLNKFDIFEKKILKVPLNVCEWFKDYQPVSTGKQEIEHAYEFVKKKFEESYFQNTAPDRVDRVFKIYRTTALDQKVVKKTFKLVDETLRRRNLFEAGLL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-1 subunit, GP-alpha-1.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: TRPA_VIBME
Sequence: MDRYQHLFQRLAAHNQGAFVPFVTIGDPNPQQSLRIMQTLVEAGADALELGIPFSDPLADGPTIQGAISALDSGTKPIRCFEADQAPIRAQDIPIYLLMYANLVYARGIDNFYQRCQQAGVDSVLIADVPTNESAEFGPAAKKYAIHPIFIAPPTASDETLQSVAELGSGYTYLLSRSGVTGAETKANMPVHALLERLNQFSAPPRRLGFGISEPEQVKQAIESGAAGAISGSAVVKIIEHHLAKPEAMLAELKTFVSAMKSATKHDK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: AP1S1_SCHPO
Sequence: MSIKFFLLVSRQGKVRLAKWFNTLSIKERAKIIRDVSSLVITRKPKMCNFVEYKGEKIVYRRYASLFFVCGIEQDDNELIILEVIHKFVECLDKYFGNVCELDLIFNFEKAYYVMEELLLAGELQESSKTNVLSAVLAGDAESEADAQQDSLQKLVGSVKKR
What is the function of this protein?
Component of the AP-1 complex which links clathrin to receptors in coated vesicles.  Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
What are the official names of this protein?
AP-1 complex subunit sigma-1, Sigma1-adaptin, Valproic acid-sensitive protein 2.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Endosome. Golgi apparatus.
Protein: MTGA_ECOSE
Sequence: MSKSRLTVFSFVRRFLLRLMVVLAVFWGGGIALFSVAPVPFSAVMVERQVSAWLHGNFRYVAHSDWVSMDQISPWMGLAVIAAEDQKFPEHWGFDVASIEKALAHNERNENRIRGASTISQQTAKNLFLWDGRSWVRKGLEAGLTLGIETVWSKKRILTVYLNIAEFGDGVFGVEAAAQRYFHKPASKLTRSEAALLAAVLPNPLRFKVSSPSGYVRSRQAWILRQMYQLGGEPFMQQHQLD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MTNN_SALPA
Sequence: MKIGIIGAMEEEVTLLRDKIDNRQTITLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLGHCKPDVIINTGSAGGLASTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAESCIRELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPDAVAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSTLMVETLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: UTH1_YEAS1
Sequence: MKLSALLALSASTAVLAAPAVHHSDNHHHNDKRAVVTVTQYVNADGTVVIPAANTATSAAADGKVESVAAATTTLSSTAAAATTSAAASSSSSSSSSSSSVGSGDFEDGTISCSDFPSGQGAVSLDWLGLGGWASIMDMNGNTATSCQDGYYCSYACSPGYAKTQWPSEQPSDGRSVGGLYCKNGKLYRSNTDTNSLCVEGQGSAQAVNKVSGSIAICGTDYPGSENMVVPTVVGAGSSQPINVIKEDSYYQWQGKKTSAQYYVNNAGVSVEDGCIWGTEGSGVGNWAPVVLGAGYTDGITYLSIIPNPNNKEAPNFNIKIVATDGSTVNGACSYENGVYSGSGSDGCTVSVTSGSANFVFY
What is the function of this protein?
Involved in aging, oxidative stress response, and in the regulation of mitochondrial biogenesis.  Inactivation of UTH1 increases life span, leads to higher resistance to heat stress and to hydrogen peroxide, and increases sensitivity to the superoxide radical-generating drug paraquat and to copper.  Also required for the selective autophagic degradation of mitochondria (mitophagy) in response to nitrogen starvation.  Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation.  Involved in cell sensitivity to boric acid (By similarity).
What are the official names of this protein?
Probable secreted beta-glucosidase UTH1, Youth protein 1.
What is the protein family that this protein belongs to?
Belongs to the SUN family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein. Secreted, cell wall. Note=Non-covalently bound to the cell wall.
Protein: NCSB1_STRCZ
Sequence: MGKRAAHIGLRALADLATPMAVRVAATLRVADHIAAGHRTAAEIASAAGAHADSLDRLLRHLVAVGLFTRDGQGVYGLTEFGEQLRDDHAAGKRKWLDMNSAVGRGDLGFVELAHSIRTGQPAYPVRYGTSFWEDLGSDPVLSASFDTLMSHHLELDYTGIAAKYDWAALGHVVDVGGGSGGLLSALLTAHEDLSGTVLDLQGPASAAHRRFLDTGLSGRAQVVVGSFFDPLPAGAGGYVLSAVLHDWDDLSAVAILRRCAEAAGSGGVVLVIEAVAGDEHAGTGMDLRMLTYFGGKERSLAELGELAAQAGLAVRAAHPISYVSIVEMTAL
What is the function of this protein?
S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes regiospecific methylation at the 7-hydroxy group of 2,7-dihydroxy-5-methyl-1-naphthoate in the biosynthesis of the naphthoate moiety of the neocarzinostatin chromophore.  Also recognizes other dihydroxynaphthoate as substrates and catalyzes their regiospecific O-methylation.  The carboxylate and its ortho-hydroxy groups of the substrate appear to be crucial for NcsB1 substrate recognition and binding, and O-methylation takes place only at the free hydroxy group of these dihydroxynaphthoic acids.
What are the official names of this protein?
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase, Neocarzinostatin O-methyltransferase, Neocarzinostatin biosynthesis protein B1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.