PharMolix/UniProtQA huggingface dataset:
Protein: MFFB_DANRE
Sequence: MSGAAFPSPTAEIAEMNRIHYELEYTEGISQRMRIPEQLKVAPYGSEDQELPDHELLHTAMMHVPERIIVAGHSDDMPFPRDLDLIQSTPQESTLSLKTPPRVLTLSDRPLDFLEMEQTSSVSHPSEEVRTQTKTRRERSVSENAGVHHNGPLARNDSAFALATLDSTLEGGTDDMAVVDATSLRRQIVKLNRRLQLLEEENKERAKREMVMYSITVAFWLVNSWVWFRR
What is the function of this protein?
Plays a role in mitochondrial and peroxisomal fission.  Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity).
What are the official names of this protein?
Mitochondrial fission factor homolog B.
What is the protein family that this protein belongs to?
Belongs to the Tango11 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome.
Protein: PROF_ARAHY
Sequence: MSWQTYVDNHLLCEIEGDHLSSAAILGQDGGVWAQSSHFPQFKPEEITAIMNDFAEPGSLAPTGLYLGGTKYMVIQGEPGAIIPGKKGPGGVTIEKTNQALIIGIYDKPMTPGQCNMIVERLGDYLIDTGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RLMH_BREBN
Sequence: MQISIITVGKLKEKYLREGIDEYSKRLSAYCKLQVIEVNDEKAPEEMSAAEMEQVKRKEGERILAQIKQDQYVIALAIDGQMWSSEKLSAEMDKLALHGRSQVAFVIGGSLGLADQVLKRADALLSFSKMTFPHQLVRLVLLEQVYRAFRISRGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_AGRFC
Sequence: MHQSFDVVVIGGGHAGSEAAAAAARHGAKTALVTHKREAIGVMSCNPAIGGLGKGHLVREIDALDGLMGRVADAAGIQFRMLNRKKGPAVRGPRTQADRRLYREAMQREIDAMDNLTIIEGDAFDIEMDNDRVAAVIMKNGSRIPCGAVVLTSGTFLRGLIHIGSEKIPAGRVGEMPSLGLSDTLSRLGLAMGRLKTGTPARLDGRTIDWNAVDRQAADEDPVPFSFMTDHILNPQIECGVTRTTPASHKIIQDNIHLSAMYSGQIEGVGPRYCPSIEDKITRFGERDGHQIFLEPEGLDDYTIYPNGISTSLPAFVQEQFIRTIPGLEQVTILQPGYAIEYDYVDPRELKPSLECRKIPGLFLAGQINGTTGYEEAGAQGLVAGLNASLYAGSADPLHFSRTESYIGVMIDDLTSKGVSEPYRMFTSRAEYRLSLRVDNADLRLTPVAQKAGILGRERQQRFTDFLSDLDSVRALMKELSISPSQAAKQGLKLNQDGQRRSVYELLAYPDMTLQALAEHWPELNRLNAKVAEVLQIEASYAVYMQRQSADIVDIKRDEDRKIPDDFDFQSLSGLSNELKQKLEKARPENIAQAARVDGMTPAAISLLLALLRKGTATRSEQLRMHQ
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTPX_CANAW
Sequence: MTTPLSSYSTTVTNHHPTFSFESLNSISSNNSTRNNQSNSVNSLLYFNSSGSSMVSSSSDAAPTSISTTTTSTTSMTDASANADNQQVYTITEEDSINDINRKEQNSFSIQPNQTPTMLPTSSYTLQRPPGLHEYTSSISSISSTSSNSTSAPVSPALINYSPKHSRKPNSLNLNRNMKNLSLNLHDSTNGYTSPLPKSTNSNQPRGNFIMDSPSKKSTPVNRIGNNNGNDYINATLLQTPSITQTPTMPPPLSLAQGPPSSVGSESVYKFPLISNACLNYSAGDSDSEVESISMKQAAKNTIIPPMAPPFALQSKSSPLSTPPRLHSPLGVDRGLPISMSPIQSSLNQKFNNITLQTPLNSSFSINNDEATNFNNKNNKNNNNNSTATTTITNTILSTPQNVRYNSKKFHPPEELQESTSINAYPNGPKNVLNNLIYLYSDPAQGKIDINKFDLVINVAKECDNMSLQYMNQVPNQREYVYIPWSHNSNISKDLFQITNKIDQFFTNGRKILIHCQCGVSRSACVVVAFYMKKFQLGVNEAYELLKNGDQKYIDACDRICPNMNLIFELMEFGDKLNNNEISTQQLLMNSPPTINL
What are the official names of this protein?
Probable tyrosine-protein phosphatase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Protein: CCSA_MANES
Sequence: MIFSTLEHILTHISFSVVSIVITIHLITLLADEFVELYDSSEKGMITTFFCITGLLVTRWIFLGHLPLSDLYESLIFLSWSFSIIHMVPYFKKHKNFLSAITAPSTFFTQGFATSGLLTDMHQSEILVPALQSQWLMMHVSMMILGYAALLCGSLFSVAFLVITFRKIIRIFDKSNNLLNNSFFFSEIQYMAERKNVLRNISFLSSRNYYRFQLIQQLDDWGYRIISIGFIFLTIGILSGAVWANEAWGSYWNWDPKETWAFITWTIFAIYFHIRTNKKLEGFHSAIVASIGFLLIWICYFGVNLLGIGLHSYGSFTLTISI
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL9_MYCPU
Sequence: MKLILIKDCPSGKANTIVEVSDGYAKNFLIPRKFAIAYTEENAKKLKQKLEQEKLDFSLKTKEFLELKEKLEKLKLTFKLKASLDKNHKLETHHSISAKKLLERLHELGFDLPKHSIEKVHLNLIGINHVNVKLFDKIVAKLTVVIEADV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: LIP2_DIURU
Sequence: MKLCLLALGAAVAAAPTATLANGDTITGLNAIVNEKFLGIPFAEPPVGTLRFKPPVPYSASLNGQQFTSYGPSCMQMNPMGSFEDTLPKNARHLVLQSKIFQVVLPNDEDCLTINVIRPPGTRASAGLPVMLWIFGGGFELGGSSLFPGDQMVAKSVLMGKPVIHVSMNYRVASWGFLAGPDIQNEGSGNAGLHDQRLAMQWVADNIAGFGGDPSKVTIYGESAGSMSTFVHLVWNDGDNTYNGKPLFRAAIMQSGCMVPSDPVDGTYGTEIYNQVVASAGCGSASDKLACLRGLSQDTLYQATSDTPGVLAYPSLRLSYLPRPDGTFITDDMYALVRDGKYAHVPVIIGDQNDEGTLFGLSSLNVTTDAQARAYFKQSFIHASDAEIDTLMAAYTSDITQGSPFDTGIFNAITPQFKRISALLGDLAFTLARRYFLNYYQGGTKYSFLSKQLSGLPVLGTFHGNDIIWQDYLVGSGSVIYNNAFIAFANDLDPNKAGLWTNWPTYTSSSQSGNNLMQINGLGLYTGKDNFRPDAYSALFSNPPSFFV
What are the official names of this protein?
Lipase 2.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
Protein: GWL_HUMAN
Sequence: MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQPDDETDTSYFEARNTAQHLTVSGFSL
What is the function of this protein?
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance.  Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively.  ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A.  Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high.  Following DNA damage, it is also involved in checkpoint recovery by being inhibited.  Phosphorylates histone protein in vitro; however such activity is unsure in vivo.  May be involved in megakaryocyte differentiation.
What are the official names of this protein?
Serine/threonine-protein kinase greatwall, GW, GWL, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cleavage furrow. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow.
Protein: DLTC_LACLM
Sequence: MKEQIFDIIETISGTDEFREDLDMDLFEEGILDSMRAIMLIVELEGAFDISLPPSEMDREDWNTANKIAARVQEKTDEN
What is the function of this protein?
Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA).  The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA.  The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanyl carrier protein, DCP, D-alanine--poly(phosphoribitol) ligase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DltC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBEAG_HBVF6
Sequence: MQLFHLCLIISCSCPTVQASKLCLGWLWGMDIDPYKEFGASVELFSFLASDFFPSVRDLLDTASALYRDALESPEHCTPNHTALRQAILCWGELMTLASWVGNNLEDPAARDLVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: VP2_POVMC
Sequence: MGAALTILVDLIEGLAEVSTLTGLSAEAILSGEALAALDGEITALTLEGVMSSETALATMGISEEVYGFVSTVPVFVNRTAGAIWLMQTVQGASTISLGIQRYLHNEEVPTVNRNMALIPWRDPALLDIYFPGVNQFAHALNVVHDWGHGLLHSVGRYVWQMVVQETQHRLEGAVRELTVRQTHTFLDGLARLLENTRWVVSNAPQSAIDAINRGASSASSGYSSLSDYYRQLGLNPPQRRALFNRIEGSMGNGGPTPAAHIQDESGEVIKFYQAQVVSHQRVTPDWMLPLILGLYGDITPTWATVIEEDGPQKKKRRL
What is the function of this protein?
Structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers.  Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane.  Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2 or VP3 nuclear localization signal (shared C-terminus).  Plays a role in virion assembly within the nucleus (By similarity).
What are the official names of this protein?
Minor capsid protein VP2, Minor structural protein VP2.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses capsid protein VP2 family.
What are the subcellular locations of this protein?
[Isoform VP2]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane. SUBCELLULAR LOCATION: [Isoform VP3]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane.
Protein: PANB_COXBU
Sequence: MIAMNTPDFQRMKKDNKKISMVTCYDYWSACIISQSNVDCILVGDSLAMVMYGHSTTLPATVEIMAQHIQAVSRGAPNKFIIGDMPFCSYRKDLTTSMNAVERLMQAGAQAIKLEGADAHNLKFIHHVVKSGIPVIGHLGLTPQSIYTLGGFKVQGKEPSAAKKLMADAKALAETGCFAVVLECVPSELAELITHSISIPTIGIGAGPATSGQVLVLQDLLGTNNQFQPKYLKKFLNGFELIKKALDDFDQEVKTSTYPHLETHCY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHH_BRUSI
Sequence: MTASQDFVVKDISLADWGRKELDIAETEMPGLMAAREEFGKSQPLKGARISGSLHMTIQTAVLIETLKVLGAEVRWASCNIFSTQDHAAAAIAATGTPVFAVKGETLEEYWTYTDQIFQWPDGEPSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEEEVLFAQIKKRMAATPGFFTKQRAAIKGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAAMDGFEVVTLDDAASTADIVVTTTGNKDVITIDHMRKMKDMCIVGNIGHFDNEIQVAALRNLKWTNVKPQVDLIEFPDGKRLILLSEGRLLNLGNATGHPSFVMSASFTNQVLGQIELFTRTDAYKNEVYVLPKHLDEKVARLHLDKLGAKLTVLSEEQAAYIGVTPQGPFKSEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUA4_DANRE
Sequence: MLATVMKQLKSHPALIPLFIFIGGGATMSMLYLGRLALKNPDCSWDRKNNPEPWNKLGPNDQYKLFSVNMDYSKLKKDRPDF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.  NDUFA4 is required for complex IV maintenance.
What are the official names of this protein?
Cytochrome c oxidase subunit NDUFA4.
What is the protein family that this protein belongs to?
Belongs to the complex IV NDUFA4 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: MATRX_TAVCV
Sequence: METPIIPSSSSLDRSGNSSNLLSVIPFQERTDSIIGCHFTLEIKAYHPDMMKSSEEGDVTLGSLYQGIHHIIRNKECQGLILGMDATHENKLHILALAFLCVIRKYEGKVSTYIERSKDTFSGVEQLLARIHIGDDHLGTYDPEVYQICGVEVPQGTYQLTLRTVLTPHNHTDGLSITLGIIVNSPARGMQGRSPMGVDVKRLILSFPKGTDPWTSYGEIKDKKGAVSKLKSILF
What is the function of this protein?
Plays a major role in assembly and budding of virion.  Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form.  Inhibits viral transcription and stimulates replication (By similarity).
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the nucleorhabdovirus type-2 matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein.
Protein: NAR1_ARATH
Sequence: MSEKFSPTLRLGDLNDFIAPSQACVISLKDSKPIVKKSDRPQVVIAPKQQLEPVKISLKDCLACSGCITSAETVMLEKQSLDEFLSALSKGKDVVVSVSPQSRASLAVHYDISPLQVFKKLTTFLKSLGVKAVFDTSCSRDLVLIESCNEFVSRYKQANSDDGENSQSPLPVLSSACPGWICYAEKQLGSYVLPYVSSVKSPQQAIGAAIKHHLCQALGLRLHEVYHVTVMPCYDKKLEAARDDFVFDDGTQDNGDLKLTEVDSVLTTGEIMDLIKLKGVDFKDLEESPLDRVLTNVTEEGDLYGVAGSSGGYAETIFRHAAKALFGQTIEGPLEFKTLRNSDFREVTLQLEGKTVLKFALCYGFQNLQNIVRRVKTRKCDYQYVEIMACPAGCLNGGGQIKPKTGQSQKELIHSLEATYMNDTTLNTDPYQNPTAKRLFEEWLKEPGSNEAKKYLHTQYHPVVKSVTSQLNNW
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:23104832).  Required for the maturation of extramitochondrial Fe/S proteins (By similarity).  Required for expression of the imprinted FWA gene, for seed development and is involved in the oxidative stress response in vegetative tissues (PubMed:23734982).  Involved in the regulation of cell size, ploidy and cell cycle progression (PubMed:23639116).  Required for growth under normoxic conditions and necessary for recovery after hypoxic treatment but its action is reactive oxygen species (ROS) independent (PubMed:23639116).
What are the official names of this protein?
Protein NAR1, Nuclear architecture related 1, Protein GROWTH AT DIFFERENT OXYGEN LEVELS INFLUENCES MORPHOGENESIS, [FeFe]-hydrogenase-like protein GOLLUM.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: DOC11_MOUSE
Sequence: MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFMVNCHDLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSNDGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYAEV
What is the function of this protein?
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601).  Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399).  Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997).
What are the official names of this protein?
Dedicator of cytokinesis protein 11, Activated Cdc42-associated guanine nucleotide exchange factor, ACG, Zizimin-2.
What is the protein family that this protein belongs to?
Belongs to the DOCK family.
Protein: RS6_GEOKA
Sequence: MRKYEIMYIIRPNMDDEARQALVERFNNVLKENGAEITNVTDWGKRRLAYEIQKYRDGYYMIVNVVSEPKAVQEFDRLARISEDIIRHIVVKEEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: ANKS3_RAT
Sequence: MSELSDEASEPELLNRSLSMWHGLGAQVSREELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQQMVKFLLESGANANVREPVYGFTPLMEAAAAGHEIIVQYFLNHGVKVDTRDHSGATARMLAKQYGHMKIVALMETHSPVLPKSLYRSSENYEDLSSSDESWPVPQRQRPCRKKGLSIHEGPRALARITATGLGGKTPDSYEQVPPRGYVTFTSSDENTMEGEGLCYRDVTSPINERDVESSSSSSREEPTFCASLGPVWRSSSSDGLARAQGLSSEASIESNEDSDHARKSSVRKQTRTYLKNKSRHNNSDGHWPSSTGTARTPGSEPQAEKSPYSGPQDLATLLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLEAEMQELAIQLHKCCEEAEALRGQVSQEQELRAVVESCLLEQDSARKDIHAQLQEAQTLAQDAALVLDQLRACQAELSARLKQHHSPSEATQNPPFLPADSKGWPIPLQALSLPELSGALEDRVHEMGIMLRNAEPGETTDAEWEEMEGTIARRDDSDVG
What is the function of this protein?
May be involved in vasopressin signaling in the kidney.
What are the official names of this protein?
Ankyrin repeat and SAM domain-containing protein 3.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm.
Protein: VATB_ENTFA
Sequence: MIKEYRTINEVVGPLMIVEKVAGVKYEELIEVRMQNGEIRQGQVLEINGDKAMVQIFEGTSNINIRDSKVRFLGHPLELGVSPDMMGRVFDGLGRLKDNGPELLPEKKLDINGEVINPVARDYPDEFIQTGISAIDHLNTLVRGQKLPVFSASGLPHKELAAQIARQANVLNSEEEFAVVFAAIGITFEEAEYFMEDFRQTGAIDRSVLFMNLANDPAIERIATPRMALTAAEYLAYEKGMHVLVIMTDMTNYCEALREISAARREVPGRRGYPGYLYTNLATLYERAGRIRGSKGSVTQIPILTMPEEDKTHPIPDLTGYITEGQIILSRELYKSGIQPPIDVLPSLSRLKDKGTGEGKTRGDHAATMNQLFSAYAQGKQAKELAVILGESALSDVDKIYAAFAQRFEEEYVNQGFDTNRSIEETLDLGWELLSMLPRTELKRIKEDMLDQYLTEGK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: IF1_CAMJR
Sequence: MAKDDVIEIDGTVLEALPNANFKVELDNKHVILCHIAGKMRMHYIRIMPGDKVKVELTPYSLDKGRITFRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FL3H_VITVI
Sequence: MAPTTLTALAGEKTLQSSFVRDEDERPKVAYNDFSNEIPVISLTKESMKLAAVVDEICRKIVEACEDWGIFQVVNHGVDSNLISEMTRLAREFFALPPEENVRFDMSGGKKGGFIVSSHLQGEAVQDWREIVTYFSYPLRTRDYSRWPDKPEGWRSVTQEYSEKLMGLACKLLEVLSEAMDLDKDALTNACVDMDQKVVVNFYPQCPQPDLTLGLKRHTDPGTITLLLQDQVGGLQATRDGGKTWITVQPVEGAFVVNLGDHGHYLSNGRFKNADHQAVVNSNHSRLSIATFQNPAPEATVYPLKIREGEKAVLEGPITFAEMYRRKMSKDLELARLKKLAKEQQLQDVEKAKLESKPIDQILA
What is the function of this protein?
Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R-dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.
What are the official names of this protein?
Naringenin,2-oxoglutarate 3-dioxygenase, FHT, Flavanone-3-hydroxylase, F3H.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.