PharMolix/UniProtQA huggingface dataset:
Protein: MEF2C_PONAB
Sequence: MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
What is the function of this protein?
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes.  Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development.  Enhances transcriptional activation mediated by SOX18.  Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission.  Crucial for normal neuronal development, distribution, and electrical activity in the neocortex.  Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis.  Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.  May also be involved in neurogenesis and in the development of cortical architecture (By similarity).
What are the official names of this protein?
Myocyte-specific enhancer factor 2C.
What is the protein family that this protein belongs to?
Belongs to the MEF2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, sarcoplasm.
Protein: GREA_CHLPM
Sequence: MSDRVYLTRDGYNRLKDELHELLHVTRAEVLEKIAEARSHGDLSENAEYDAAREQQSQTEARIADLESKLSSATILDPKHIKTDKVYILTSVELLNLDDKKETLEYTLVSSEESDSDLGKISVRSPVGRALIGKAVGDKVTIIVPKGELHYEVKKIFVK
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: FKB1A_RAT
Sequence: MGVQVETISSGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFTLGKQEVIRGWEEGVAQMSVGQRAKLIISPDYAYGATGHPGIIPPHATLVFDVELLKLE
What is the function of this protein?
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand.  Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.  May modulate the RYR1 calcium channel activity.  PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP1A, PPIase FKBP1A, 12 kDa FK506-binding protein, 12 kDa FKBP, FKBP-12, FK506-binding protein 1A, FKBP-1A, Immunophilin FKBP12, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LEP4_SYNY3
Sequence: MDPLIAPLAFLLAIALGCAVGSFLNVVAYRLPEGLSLVHPPSRCPHCGHRLGPKENVPVVGWLWLRGKCRWCQTAISPRYPLVEAATGFLFALTCWRFGWQWQTFGYWILISFLISLTLIDWDTMTLPNSLTKPGLVLGLLFHLLLGWQRGHWIVPLVEAIASAVLGLWLFDLIRMGGSLLLGREGMGDGDPKLASMVGAWLGWPSLLLTTFIACFIGSIYGGLKLLLGTLQRRQGFPFGPFLAIGALISLFWGEKLITSYLNFVTPQF
What is the function of this protein?
Plays a role in type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.  Substrates include proteins required for biogenesis of the type II general secretory apparatus.
What are the official names of this protein?
Prepilin leader peptidase/N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A24 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MYO1_NEOFI
Sequence: MGHSRRPAGGEKKSRGFGRSKAAADVGDGRQTGGKPQVKKATFESTKKKEIGVSDLTLLSKISNEAINDNLKLRFEHDEIYTYIGHVLVSVNPFQDLGIYTDNVLQSYRGKNRLEVPPHVFAVAESAYYNMKSYKDNQCVIISGESGAGKTEAAKRIMQYIASVSGGTDSSIQHTKEMVLATNPLLESFGNAKTLRNNNSSRFGKYLELEFNTNGEPVGANITNYLLEKSRVVGQITNERNFHIFYQFTKAAPQKYRDLFGIQQPQSYLYTSRSKCYDVPGVDDSAEFRDTLNAMNVIGMTEGEQDDVFRMLAAILWIGNVQFAEDDSGNAVITDQSVVDYVAYLLEVDAAQVNKAFTIRVMETARGGRRGSVYEVPLNTVQALAVRDALAKAIYFNLFDWIVQRVNASLTARGEVANSIGILDIYGFEIFEKNSFEQLCINYVNEKLQQIFIQLTLKAEQDEYAREQIQWTPIKYFDNKVVCSLIEDKRPPGVFAALNDACATAHADSSAADNTFVGRLNFLSQNPNFENRQGQFIVKHYAGDVSYAVAGMTDKNKDQLLKDLLNLVGTSGNQFVHTLFPEQVNQDDKRRPPTASDKIKASANDLVATLMKAQPSYIRTIKPNDNKAPKEYNVGNVLHQIKYLGLQENVRIRRAGFAYRQTFDKFVERFYLLSPKTSYAGDYTWTGDAESGARQILKDTSIPAEEYQMGITKVFVKTPETLFALEAMRDRYWHNMAIRIQRAWRNYLRYRTECAIRIQRFWRRTTGGLEFIKLRDQGHQLLNGRKERRRMSLLGSRRFLGDYIGVGNKGGPGEMVRNGAGISGSEDILFSCRGEVLVSKFGRSSKPAPRILVLTNRHVYIIAQNLVNNQLVISSERTIPIGAIKAVSASNLKDDWFSIVVGSPQEPDPLVNCVFKTEFFTHLNNTLHGQLNLKIADHIEYNKKPGKLATVKVVKDPAVARDDSYKSGTIHTGPGEPANSVSKPTPRPKQVSARPVTKGKLLRPGGPGGGPSKLAARPTPAAQPLPRATPQPAAPQPAARAVPQPVAAVAASHTRTGSTASVRAPPPPPPAAAPAPKKPTAKVLYDFNSQQSNELSIKAGEIVQIVSKEGNGWWLCMNMTTSAQGWTPEAYLEEQVAPTPKPAPPPPPPAAPRSTPAPATNGAAAAAKAKPAPPAPPAKRPNMAARKAVPTPPPAPRDSAVSMNSHDSSGGSGRGTPNSMSNASLAGGLAEALRARQHAMQGKQDDDDDW
What is the function of this protein?
Type-I myosin implicated in the organization of the actin cytoskeleton.  Required for proper actin cytoskeleton polarization.  At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly.  Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.  Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation (By similarity).
What are the official names of this protein?
Myosin-1, Class I unconventional myosin, Type I myosin.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch. Note=Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation (By similarity).
Protein: TRM1_HHV7J
Sequence: MNSLQSLCVLCSRLSECALELECLRFCDPVTLIPDMTNFRKNGVVIIHLFKTLFAELCHQNFNCASPVTIYLQILLKAMYNQVLLLDASIHQFLLDNDKQKYFENIFQLNECKQHLKLDLALNNYLTFSVDISTINDIEKLLCKMNCIFGLISPLDGINACSQIIEFLTILCGVCVVMKPEVFSETTTCLKCYEELSLVPNQGKSIRKRLAGKFCNHLTETHMVSNLEKNVDIIEKDLDFSTKQYGLVKEYMAKITNIFQQQLYSKPPHLQEAENTLINFDLFSKIPDTIYSLSEFTYWSKISESVIQKASITLNQLNLCHSLYADLQNEISKFLYGETIQDVFNFNEENVTNDDKLYIGSRFISPCRLVDIITNVSIKNLEEDPVFTKLAEEDEIQTKIKTLLNELENSAHETVPKKYVTHSMTQDHNLQQEIHIRKKAYYQKISESGYSKVMLCIKEQEALINKLMNINILGNHIFESLSKMMNAFANRQLQSLENFSADPFTYDDHLYIKNNLLSKKLPQELLPNLSQEMYRLLTGPLSNYHTASFPLSSNISMAYACDVADFLPHMKEDLAKCVEGTIYPENWMLCTYNKFFNFDGLHNINDMQRQMWNFIRELVLSVALYNDVFGKQLSIVKFGEETETVEKILLTFDSGSPLLFKRGTTTTKFNDLYSLLYFDLKTQCDPVQISQTKQVSHIPAPNLLDLCRQNENSIPECFYNF
What is the function of this protein?
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging.  Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm.  Once the complex reaches the host nucleus, it interacts with the capsid portal vertex.  This portal forms a ring in which genomic DNA is translocated into the capsid.  TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
What are the official names of this protein?
Tripartite terminase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRM1 protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
Protein: DAPH_STRP7
Sequence: MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLGNVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVEIGDNAVIMMGAVINIGAEIGAGTMIDMGAILGGRAIVGKNSHVGAGAVLAGVIEPASAEPVRVGDNVLIGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQTQQKTALEDALRTL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: TBB_PLAFK
Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGTYCGDSDLQLERVDVFYNEATGGRYVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDAVLDVVRKEAEGCDCLQGFQITHSLGGGTGSGMGTLLISKIREEYPDRIMETFSVFPSPKVSDTVVEPYNATLSVHQLVENADEVQVIDNEALYDICFRTLKLTTPTYGDLNHLVSAAMSGVTCSLRFPGQLNSDLRKLAVNLIPFPRLHFFMIGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMCASDPRHGRYLTACAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPHNTKSSVCDIPPKGLKMAVTFVGNSTAIQEMFKRVSDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEEGDVEA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Localizes to the parasite surface in subpellicular regions in trophozoites and schizonts (By similarity). In merozoites, localize to the apical end of the parasite (By similarity).
Protein: APOA4_FELCA
Sequence: MFLRAVVLTLALVAVTGARAEVSPDQVATVVWDYFSQLSNNAKEAVEHLQQSELTQQLNALFQDKLGQVNTYADNLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLGPYADELRTQVNTHAEHLRRHLTSHAQRMEAVLRENVDNLQSSLTPYADEFKAKIDQNIEELKGHLTPYADELKVKIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKNAEELKAKITANADELRQRLAPVAEDVRSKLRDNAKGLQESLAQLNSHLDRQVEEFRRNLGPYGDTFNRALVQQVEELRQKLGPYAGGMEDHLSFLEKDLRDKVNSFFITLKEKENQDRPLALPEQEQAPGPLES
What is the function of this protein?
May have a role in chylomicrons and VLDL secretion and catabolism.  Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT.  Apoa-IV is a major component of HDL and chylomicrons.
What are the official names of this protein?
Apolipoprotein A-IV, Apo-AIV, ApoA-IV, Apolipoprotein A4.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: CE162_DANRE
Sequence: MAHRLTKEELDQQFEQFLKESVSDDSVDLGTSSKRPSVLDSLGKAPVRPVKKASASVPWWQDDDDNDDDSEEKGMSSTGRSFLKSLRKTPSIKEVDEEQPKELFLEDEGNRDHVILSRDSLEPEDSLVIPSAGARGLDTLDEDDDDARFLSNLKKVSSSSIDFSRINREQELSAPTSPLRREEMDSTIEEEQRMNKDTAASPAYSEDFEEEASDKSDVEPQEKKPERLGMLAKVSLHDSLNSTDGALAPAVPSLAVARENRPESKQTDMPALEPAVQSYGQSGGSEMEALQEAYRQISGSAGVCEDGQVEAGRTPLSLSTLQPASTVESDLPTAEELMQPIGPDSGFTRGFSLQPITEAVPRSRDNQSPLRISSDESPFSSANEGYGGGNTANLTGGEHPDSYKFTQKSISEEIRRLMQEQDTSSQEPPPLKPKKRQVPARSNASTSASSRKAPVPSVRVKKPESKPLHRVPAPSRAAQAAKPPSPPTLRKAQNQTFKKTQNLNQTHTIKGLDTSLKLSSELVESVQSFAAFLQHQVEASSLQDKGPFQANKIASEAMTAHKGMQEKMDGGPELASLERLRLQLAKKERELSLREDQLQEQHKQELTALRQENYILQSKLHRAEEASNKRKWSFGEASDPVTEEKLKLIEKEMKEQETLIQGYHQENEKLYLQMKALQAQSKQNEEALFMENQRLLTELSFARDRMNTNNIQRTIRERSIVDQSFNIAELTSQVQAAQKKEERLQEEVRRLKQEKQALHVDLEMMRKERDLAKVQAVCKSGDKGFELKLLHDKHREEVTELKKRLQWYAKNQELLDKDAARLHAATAEIQKLTEQVEKLKAEVSRRANEQQRKAKEKAGEAKRIQDLERQLKQKEELLKRRHPNSLPALILAAASTGAEEDRLDVRSLAQSSQTAALLERRVHRLEAELEGRDEAAKRSLRAMEQQYHRIKLQYEQQISDLEQRLSEKSHSYPAISSELIKSHTQTLKAELEEVKEVHQKQVSVLQAEVDSLQEQLRQAQASTQTEKPARSPSRHQLHAEAAQAARIERLTQELNSKSRSIQELTRTIERLQRERRTMLSGPSHERPNNEPKRHLGTAKDTKKPSVETFPPTQDEKDYHPGAFSGTHISEVQLENDSLRTKLEELEVLREKEKVSLQAAVTHAQNQLLRIEEQNAEQLTSVKAEHRKEIEHLLARHALEHSSSRVAELTSQLNTQEIIVQHLQGQVKELQGTKEALAVTKLREETLQNQLSKLLEELKEAKEAHSPELKHFTSLEQKIQSMEFRYSQREKQLQQVIADTRRVVEQEQQSEVERWRKLAQGRAKELEAFRMELDSILDVLRELQRQGVVIPMPEHTSTNTHTYLPLRS
What is the function of this protein?
Required to promote assembly of the transition zone in primary cilia.  Acts by specifically recognizing and binding the axonemal microtubule.
What are the official names of this protein?
Centrosomal protein of 162 kDa, Cep162.
What is the protein family that this protein belongs to?
Belongs to the CEP162 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the distal end of centrioles throughout the cell cycle.
Protein: XKDE_BACSU
Sequence: MHNQTVRATVFKANAAAPQTKQIYEDDFSELYGEDIIAPPYNIIELKTIAEYSTILQQCIDAYRVNITGFGFDVEYTFDVNASDVDQAKKKRAEKDWARLEAFYKCLHFDESAEMILGYAIEDREKTGNGFMEVLRDGAGKPAGIEYLDVKYMRVCGAGEPVEVSFVYEENGKMKRIKRQKRFRKYVQMINGKKVFFKEYGDPRKMDIRTGEYVNTLAEKYQANEAIHLKIGSGVYGVPRWIGNIVNLYGARKAEELNFMYFKQGRHVPAAITVENGMLSEASYRELQEYMNDLEGVENAHKFLLIEAEGIAKEKDLHGGEDITPVSVEIKSLAEILQNDALFLEYDEKSRNKLRSAFRLPPLYTGEAQEYNRATADTARKITEEQVFQPERKTLVNKLNTLLLPELNIHDVRLTLKGPDFRDPLEIAKVLGPFITAGAVSPNDLRDLAGRVLGKTLEEWPEDIYKRPAGQDAEKTNLAALMQELKESIEDIKTS
What are the official names of this protein?
Phage-like element PBSX protein XkdE.
What is the protein family that this protein belongs to?
Belongs to the phage portal family. PBSX subfamily.
Protein: RS7_LEPBP
Sequence: MSRRRGKVEPRHIEGDPKYNDKVISKFINCLMVDGKKSVAESVFYDALEVIAKKTGQDPFAVFQEALENAKPQVEVKSRRVGGVTYQVPIEVRPERRLALGIRWLIKYSRGRNEKSMKNKLAAEFMEAQKGTGSAIKKKEDIRKMADANKAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RL23_SHEAM
Sequence: MIREERLLKVILAPHISEKSTVVAEKTNTVVFRVAIDATKSEIKAAVEKLFEVEVAGVRTLINKGKTKRHGARVGRRSDWKKAYVTLAAGADIDFVGAEA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RPOY_BACLD
Sequence: MIYKVFYQASNDEVPVREKTDSIFVEAQSEREVRSKLKPYNYNIEFIQQVEGAFLEYEKQSENFKVLEL
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: MDM10_ASPNC
Sequence: MLDFMDYIQLAFAEATNWNRDNSYSSLTATAQSLLDFSTPERLRVHLSSLSTPHFATSYTLGTVGLIDGSVSYLFSTVPLDKFPSRSALIPLRKLSPGYRQVQAPIAPIAETILINDDLNDASAYTTIGKKATLFHATLHLPPPTTLNALFLRRISPTMQLSLAVCSTRGPPLSKSAPQASLLAQLSHNTGKYNNEYLFSTDNALFGWRGLWNFGPDPRDPVASGSSPRLSLLSAGAEAYYSPVSSLIGMSTGLRFSTANANTPISTFPYTLTLTLTPLTGSLSTTYSLRASPNLAFSSRFGFNVYSWESEMVAGCELWRKSKSRYRDDGDGVEWARRKIRESLFPHPHPHLSTSTPNDIKDLAGHALEKSGKGEEEENESVLKIRVDQSWNVRLLWEGRVKELLVLIDRVVEVYSNERCLRELRLMVVFNLDL
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the receptor tom22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the mdm12-mmm1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the tom40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component mdm10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: RPOD_PSEPU
Sequence: MSGKAQQQSRIKELITRGREQGYLTYAEVNDHLPEDISDPEQVEDIIRMINDMGINVFESAPDADALLLAEADTDEAAAEEAAAALAAVETDIRRTTDPVRMYMREMGTVELLTREGEIEIAKRIEEGIREVMGAIAHFPGTVDYILGEYDRVNRGCRLSDVLSGYIDPDDNIAAPTEEVPIPGTKAAAAKEEADDDEEESEGGDDEEEPKAALTRSSQPSVSVRYPSSFSDHQGPEEKRSYPQGKRRALQALADLFMPIKLVPKQFEVLVERVRDALNRLRQQERAIMQLCVRDARMPRADFLRMFPSNETDQTWSGDLAKRNTKWAAALGEKDAAIVACQQKLIDLETETGLTVAEIKEINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELGERMEMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDSTMQSPIYVATVESLKEATRDVLSGLTAREAKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKAWRKLRHPTRSEHLRSFLDE
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor RpoD, Sigma-70.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GASP3_HUMAN
Sequence: MAGTKNKTRAQAKTEKKAAIQAKAGAEREATGVVRPVAKTRAKAKAKTGSKTDAVAEMKAVSKNKVVAETKEGALSEPKTLGKAMGDFTPKAGNESTSSTCKNEAGTDAWFWAGEEATINSWFWNGEEAGNSFSTKNDKPEIGAQVCAEELEPAAGADCKPRSGAEEEEEENVIGNWFWEGDDTSFDPNPKPVSRIVKPQPVYEINEKNRPKDWSEVTIWPNAPAVTPAVLGFRSQAPSEASPPSYIVLASAEENACSLPVATACRPSRNTRSCSQPIPECRFDSDPCIQTIDEIRRQIRIREVNGIKPFACPCKMECYMDSEEFEKLVSLLKSTTDPLIHKIARIAMGVHNVHPFAQEFINEVGVVTLIESLLSFPSPEMRKKTVITLNPPSGDERQRKIELHVKHMCKETMSFPLNSPGQQSGLKILGQLTTDFVHHYIVANYFSELFHLLSSGNCKTRNLVLKLLLNMSENPTAARDMINMKALAALKLIFNQKEAKANLVSGVAIFINIKEHIRKGSIVVVDHLSYNTLMAIFREVKEIIETM
What is the function of this protein?
Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis.  Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP.
What are the official names of this protein?
G protein-coupled receptor associated sorting protein 3, Protein BHLHb9, bHLHb9, Transcription regulator of 60 kDa, p60TRP.
What is the protein family that this protein belongs to?
Belongs to the GPRASP family.
Protein: RECR_ECOL5
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQTLTRAMSEIGHCADCRTFTEQEVCNICSNPRRKENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLAEEKITEVILATNPTVEGEATANYIAELCAQYDVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: MED29_BOMMO
Sequence: MNHNQMNMHVPMNQVAGAPNVAMQMPVPGPIMQQQSPQQMQPAPVPQQTQQDKMDNISKVKSLMGSLRESIPMTLKSAAQILHQNHNADSNTQKGMDNPVPRFEKNLEEFFSICDQMELHLRTATTCIQQAQSAAHYLPLSVIASRLDSGPTTQETTLSYPQYLKTVGLQISYAKDIHDTLVAAAQNISPPE
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 29, Mediator complex subunit 29, Protein intersex.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 29 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SNX41_CANAL
Sequence: MSTDNLFEDIEQDNNPSFYGNPSILNDPYRPIQPPPPQQQQQQHQENESKQSHTKSPKPPLQSIHSGTSNAHPQSQPQHKHKHKHNTSLNNGYPNELVNSTIGLSNRILELLNDSQLQVDIINSEKLVNSSVIVYTIELSSPTTKIVVKRRYSEFKSLRDNLLKLFPTLIIPPIPEKHSILSYLLNTINHSHEISIIEMRKRYFKMFLDDLIFQSDYKLKNCPLLHKFFDPNYELCWYNALNEPPVSLIPDNLLLANPINPADQNGLYSLLPIVNGFDFNSHIDNLSNLKKINEDLYKLNDQVKLYELKGFEQDLEFSIPEELIQFEIKFHQTIKILTDLNKLNSKTTKNYKSMVDTLIDLGGNLNNFSLQVYQQKSGSNNELSEAIEKFGSTMDQSFLNFESFILNQLVPQWQEPVDQLILYLQNSLGLIKFYKYKIVQFKILYKLKFNKFQQLINLTNIGGVSSSGSGGGGLLASRISTDNDSNNSNNSGNNNNDGDLDTENFDHLKELNSPTINNALKNLSTKKISKKSSWYGLFGGNNQTKKFNFQLPIEEPTTATGSTEQQSQQQSAPNSPQREQQQQQSQSQSHHSHQTSIRFKLNHIEKELNKLNQLIELCNQDMHKLTEALVNTFEEFLSKIERKWLQLMITYIQNCKNMFEANLTNWKEFKESLVNETREVN
What is the function of this protein?
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
What are the official names of this protein?
Sorting nexin-41.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures.
Protein: PYRH_BORPE
Sequence: MSSRSYKRVLLKLSGEALMGEDAFGINRSTIVRMTDEIAEVAALGVELAIVIGGGNIFRGVAPGAQGMDRATADYMGMMATIMNALALQDALKHKGVDTRVQSALNIDQVVEPYIRPKALRYLEEGKVVIFAAGTGNPFFTTDTAAALRGAEIGAEIVLKATKVDGIYSADPNKDPTATRYARISFDEVIVRRLEVMDATAFALCRDQKLPIKVFSINKSGALKRAVSGEDEGTLVHV
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.