Protein: SIDE_ASPFU
Sequence: MAPVALRDLAESPELEGTEVVSMKARSSPPLTPPSPPCLVTDYIRHQVESNPDAPAVQCEQEQPYSYAALWQLVEHIAAAGQFRAGRIMPLCMDPSVEFVATVLAILRAGSAYVILDPEGSAQRNRVIAEDCGCEPVIVHEKYAAFFDHSVTIESIQSIQNHGQLDPPSITPSDLAYLIYTSGSTGTPKGVLLSHRAVSHGIDQFQLNGRKRWLLFYNPIFSAAQRTILATLSKGACLCLTRRDRLATALPEVLNNLQIDALGITPSALALLSPGETPACLQQITTVGEPLSQSLVNKWADRVHLRVSYGLSECAQLNFSRQLQPGDNPRNPGLPSDTTTAIVLEPGTMTRLSVNEPGELCLYGPQVANGYHQRQKETQAAFVKAPKDTHGTMMFRTGDLAVQREDGTFEILGRIDHQVKIHGQRVEPEEVAAKLATVKGVASLACVGCYINERMSLVAAIVPSPEADWGTLVQYLRDHARQSFPPYMVPSYWMSCTEFPTNQNGKVDFRAIRRLAESTEVSKMLGHSTSPKDGATAGLSETASKIAQVWAAVLNLPASSIIPSDSLVALGGTSIDAIRAIRELKGHGIHVELADMLQAHTIEEIADTVQLDSSPTHVSNEPAAPFDYISDAVLKADLLADRRVVDAYPVTALQEGILASTLQGSQDYLYQRVFDVRHLDLVRLQLAFQVVFWRTELLKSTFVAAAKGFLQVVRNDFNLPWSEVSLSLSEYLEQDKNNGVTLGEPFMRVAVLDRSILVVSVHHALFDFWSHRFLFDDVARVYYGRRPEKRPEWKSFVGLLHTRDTKASQDFWREHLGEAVPTVLNYAPVTKTSTARRTVSQEVRAASSALRAPLGAIIHAAWALVLSSHIASKSVTMATAVSGRELPVPGIEALNGPTLAVVPYAIAIDSEQTLQQLVQSVNTSLWKVIKHSQVGVRNALAAAERQGTTLFDTMVNILVNGKVNDDISKEVFQLYGRRPVWRTEYTTLNVEEGATGIDVTLTSPMEEHRLEFILEQFCMALNLIASNPRQTVKATNLVSETELQFMLQSHKNLPDATRTLNGQFEATVRTYPNRTAINYQNEQFLTYAELDSEANRMTHYLSELGVVPGDIVPLLLEKSPLMIKAILALFKLGAAYVPLSPENPLERNAYIARDVSAKFVLTEKEHEAYFASESDIPSVLLDQANLSQYGPEPQLVTVSPDALAYLLYTSGSTGLPKGVMVTHGACAAAMQSIIEFEHRQGQESRMLQFSNYVFDVSLYDFFVALHSGGTLCIAPSERLLNNLAEVINEMNVNHVFLTPTVARLLNPKDVPNLESMTVGGEQLTRDVVTTWASRVTLRNGYGPTEASVLVTMKDVDTDTTGGNIGRPLASVGAIVLEADGVRPVPYGAVGELCFFGPQLAQGYFKKPDITSAAFIESEVLNGRRLYRSGDLARYLPNGDIECLGRKDDQVKINGHRIELGEIEQAFLRTGEIKDCVLTVWKHNSTAHLVAVAVFDGASSEKPGEVLPLDGFAENVQRVRSKLTGLTPYMIPKAIVPLSSLPRLPSGKANRKQLKAMVQSLSQGELTKFSFDKVGAAQSKGAVIPLASETQKVLQQGWIETLQLADDDFGLEADFLSLGGDSIAAINLVSWLRRKQLKISVRDVLKYTSLGAMADQLKGESGDAHQIQKKTFTPPSEIDAAISAAGLQATEYEYIYPCPPGQAEFLTQGAHPEALWSLMTVRKVGSDFAPRQWIDLVRQLTTTNEILRTTFTRCHGNWYGVVLRDATPVVEIYEDVSNEQRQQIIKSLDDYRFVFGKPFIRYAILHLSTGETEIVTKLDHGLYDGTLLRIFGEHFQAYQDNVPVDRFTSFKDFAFHIWQMDKSRTLSFWKQSEKRPIAFEFPSSSGTEPRINSVHVHTINLEFDAFAKSTGATVSIIFQSIFQLWLALRSNQRDVAFDYLYTGRNIDLPDPQTINGTCANFLPMRSKVDPSMPVSEFLRQTQDEFWQYTENSTVGMDEIHEACETTREGFSNKTLFLFQPFEPAPATAKQYEKWIVMAKSQVTMPQPYAVVFEVVKTADVNEYKLKFAFDKRVYEKEQVQGEAQVIEKLLAKVMENAEASVGDVLGSFRS
What is the function of this protein?
Nonribosomal peptide synthase; part of the siderophore biosynthetic pathway (PubMed:17845073).  Aspergillus fumigatus produces four types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage.  TAFC consists of three N(2)-acetyl-N(5)-anhydromevalonyl-N(5)-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N(5)-acetyl-N(5)-hydroxyornithine)x3.  The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA (PubMed:15504822, PubMed:16113265).  Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split (PubMed:17845073).  For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N(5)-hydroxyornithine (PubMed:17845073).  The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively (PubMed:22106303).  The acetylation of N(5)-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL (PubMed:21622789).  FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation (PubMed:17845073).  Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively (PubMed:17845073).  Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC (PubMed:17845073).  Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence (PubMed:16113265).
What are the official names of this protein?
Nonribosomal peptide synthase sidE, NPRS sidE, Siderophore synthetase E.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.