PharMolix/UniProtQA huggingface dataset:
Protein: AROQ_THESQ
Sequence: MKVLVVNGPNLNMLGKRDKNIYGNFSHEDLVKMIEDWGRKNDVEVEVFQSNHEGEILDRLHRLDFDGLVINPGAFTHYSYAIRDALEIVKVPKVEVHISNIHRREEFRRRSVTAEVCDGQISGLGVYGYLLALEYIKKKLEELT
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: CRDL2_HUMAN
Sequence: MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASEQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEASDLVEIYLWKLVKGIFHLTQIKKVRKQDFQKEAQHFRLLAGPHEGHWNVFLAQTLELKVTASPDKVTKT
What is the function of this protein?
May inhibit BMPs activity by blocking their interaction with their receptors.  Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity).  Implicated in tumor angiogenesis.  May play a role during myoblast and osteoblast differentiation, and maturation.
What are the official names of this protein?
Chordin-like protein 2, Breast tumor novel factor 1, BNF-1, Chordin-related protein 2.
What are the subcellular locations of this protein?
[Isoform 1]: Secreted. SUBCELLULAR LOCATION: [Isoform 2]: Secreted. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm.
Protein: CSN2_STRTR
Sequence: MKINFSLLDEPMEVNLGTVLVIEDVSVFAQLVKEFYQYDEQSNLTIFDSKIRSIRSSELLLITDILGYDINTSQVLKLLHTDIVSQLNDKPEVRSEIDSLVSLITDIIMAECIENELDIEYDEITLLELIKALGVRIETKSCTVFEKIFEILQIFKYLVKKRILVFVNSLSYFSKDEIYQILEYTKLSQADVLFLEPRQIEGIQQFILDKDYILMPYNN
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable).  Binds dsDNA (By similarity).  When the CRISPR3/cas system consisting of cas9-cas1-cas2-csn2-CRISPR3 or just cas9-CRISPR3 is expressed in E. coli it prevents plasmids homologous to spacers 1 or 2 from transforming.
What are the official names of this protein?
CRISPR-associated protein Csn2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csn2 protein family.
Protein: URE2_AZOVD
Sequence: MIPGEYQIQDGEIELNAGRRTLTLNVANSGDRPIQVGSHYHFFETNDALVFDRALARGMRLNIPAGTAVRFEPGQSREVELVELAGLRRVYGFAGRVMGEL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF2_BRUC2
Sequence: MDATFWAFIALVIFVVIVVYMKVPGMIGRTLDERADRIKKELEEARTLREEAQQLLAEYHRKRKEAEKEAGDIVASAEREAKALLEEAKRATEEYVARRNKLAEQKIATAETDAINAVRASAVDLAVAAAGSILAEKVDAKAAGNLFNDALAQVKSHLN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YMJB_CAEEL
Sequence: MISPQGVAVATLLILGVVHGSLIDDLKAKFSSSSSGFGASMFSNSGAKSSFGGGFAMPKLDASKAAMVHSSSSHKGHHQSSGSSSNTHSLTVVGADGKNITENSEKKDGYNKESKVDEANENTKIKSADGSVIETGKSHNKSSDDASSYGLEKSSKTYADKNGTMLSSNTNKINNQSRSAALDEGNEFVNQQNADGTFLRNNTGHKNTDEHLSHNVLDENAQMSIGADGTSHNITNRKGSVGDSHNAASDAHSNFESLDAQGNKKSQNYSKKAASASGSNADFESNLESLKNADGTSMSNSTGNFNNTSYDKATAEEVMSKKNVNADGTSSMEASHAGSNSSKINSASGQSSDLSMVGPNGIKSHSTSNKTDNYALDEANQSAGSISEQIGKNGQRSLNESSIESGRKAESRNNTAADTLDSVDANGTVSSSHSKSASGTSLDENHNKTHALQASVDEHGNMKNHSIDGSYRNKKTGEFGNSEMSASIKNADGTMSQVNVKNDTNRNTYEAEKSALEKNHEKNSDGTFKDESKGSNSRVNRTDGGSNLAVGSYSVGKGGVSSNETIASSNAFNTSDAESNQFDHLHQKTANGTEITHAKDSKQVAASANAKSSLDTSMSAVDAKGNKVDKTSSQAADSHDAISASSDVDAKIVKHADRSESISNDSSNQTASEHNDSSKQSEHEKRQNADGSFSDVSSNSAKKNAVKDATDVRQNAFANVDAAGNSVSEVKNSLVENHSNDSDASSDSKIHSKSVDGTELTDAKHSNVSTSHLTEGQLAQIQKKLAMADGSVVMSNDNSHITHEKSRADVDAGHKAHLSKADGSSTDIDEGFKHHSDLESRGEGAQKQRYQKLGNGTESSMDVGYEKSMAKGGDQTSSHKKTLAKDGKGHFTETKDGSESHHKIDDKDVKQHKDIIQM
What are the official names of this protein?
Uncharacterized protein F59B2.12.
Protein: IAR1_ARATH
Sequence: MSFSLRKLLVPILVLVLFLDLCVESGFSQSTPARDDHVHHHGGGCSHSHDHDHDHDHDHHVKKTTAKVEMKLPEELAEEEDMRLCGFGPCLHDHDHESSSTLTGFALWLNALGCSLLVSLASLICLVLLPIMFVQGKPSKWFVDSLALFGAGAMLGDAFLHQLPHAFGGGHSHSNDHHENHDHHDHSHSDSPSHSHSIQDLSVGLSVLAGIVVFLLVEKLVRYVEENSSGSNTWGHHHHHHHAGSKKLKDEGDHNNLDQQSSSDAIVNSSEKVSGGSTDKSLRKRKTSASDATDKSDSGTEITSDGKSDKPEQVETRSSSLVFGYLNLFSDGVHNFTDGMALGSAFLIYGSVGGWSRTMFLLAHELPQEIGDFGILVRSGFTVTKALFFNFLSALVALAGTALVLVWGNEPGQSSLIEGFTAGGFIYIAVAGVLAEMNNSGKSTLKNSACHLISLILGMSVALCISLIE
What is the function of this protein?
May participate in auxin metabolism or response.  Probable transporter.
What are the official names of this protein?
IAA-alanine resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ADAM8_MOUSE
Sequence: MLGLWLLSVLWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRALPSHWGQYPESLSYALGTSGHVFTLHLRKNRDLLGSSYTETYSAANGSEVTEQLQEQDHCLYQGHVEGYEGSAASISTCAGLRGFFRVGSTVHLIEPLDADEEGQHAMYQAKHLQQKAGTCGVKDTNLNDLGPRALEIYRAQPRNWLIPRETRYVELYVVADSQEFQKLGSREAVRQRVLEVVNHVDKLYQELSFRVVLVGLEIWNKDKFYISRYANVTLENFLSWREQNLQGQHPHDNVQLITGVDFIGSTVGLAKVSALCSRHSGAVNQDHSKNSIGVASTMAHELGHNLGMSHDEDIPGCYCPEPREGGGCIMTESIGSKFPRIFSRCSKIDLESFVTKPQTGCLTNVPDVNRFVGGPVCGNLFVEHGEQCDCGTPQDCQNPCCNATTCQLVKGAECASGTCCHECKVKPAGEVCRLSKDKCDLEEFCDGRKPTCPEDAFQQNGTPCPGGYCFDGSCPTLAQQCRDLWGPGARVAADSCYTFSIPPGCNGRMYSGRINRCGALYCEGGQKPLERSFCTFSSNHGVCHALGTGSNIDTFELVLQGTKCEEGKVCMDGSCQDLRVYRSENCSAKCNNHGVCNHKRECHCHKGWAPPNCVQRLADVSDEQAASTSLPVSVVVVLVILVAAMVIVAGIVIYRKAPRQIQRRSVAPKPISGLSNPLFYTRDSSLPAKNRPPDPSETVSTNQPPRPIVKPKRPPPAPPGAVSSSPLPVPVYAPKIPNQFRPDPPTKPLPELKPKQVKPTFAPPTPPVKPGTGGTVPGATQGAGEPKVALKVPIQKR
What is the function of this protein?
Possible involvement in extravasation of leukocytes.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 8, ADAM 8, Cell surface antigen MS2, Macrophage cysteine-rich glycoprotein.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: EST_PSEAE
Sequence: MRALLLSGCLALVLLTQQAAAQTLLVVGDSISAALGLDTSQGWVALLQKRLADEGYDYRVVNASISGDTSAGGLARLPALLAEEKPALVVIELGGNDGLRGMAPAQLQQNLASMAQKARAEGAKVLLLGIQLPPNYGPRYIEAFSRVYGAVAAQEKTALVPFFLEGVGGVQGMMQADGIHPALAAQPRLLENVWPTLKPLL
What is the function of this protein?
Esterase that exhibits the highest activity towards Tween detergents and p-nitrophenyl esters of short acyl chain length.  Also displays a low thioesterase activity towards palmitoyl-coenzyme A, but is not active towards acetyl-coenzyme A.
What are the official names of this protein?
Esterase TesA.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted.
Protein: BATF3_MOUSE
Sequence: MSQGPPAVSVLQRSVDAPGNQPQSPKDDDRKVRRREKNRVAAQRSRKKQTQKADKLHEEHESLEQENSVLRREISKLKEELRHLSEVLKEHEKMCPLLLCPMNFVQLRSDPVASCLPR
What is the function of this protein?
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system.  Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.  Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens.
What are the official names of this protein?
Basic leucine zipper transcriptional factor ATF-like 3, B-ATF-3.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CALM2_MOUSE
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
What is the function of this protein?
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding.  Calcium-binding is required for the activation of calmodulin.  Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.  Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.  Mediates calcium-dependent inactivation of CACNA1C.  Positively regulates calcium-activated potassium channel activity of KCNN2.
What are the official names of this protein?
Calmodulin-2.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
Protein: FIEF_KLEPN
Sequence: MNQSYGRLVSRAAIAATAMASALLLIKIFAWWYTGSVSILAALVDSLVDIAASLTNLLVVRYSLQPADEEHTFGHGKAESLAALAQSMFISGSALFLFLTGIQHLVRPEPLQAAGVGVVVTLIALVSTLALVTFQRWVVRKTQSQAVRADMLHYQSDVMMNGAILVALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDEERQDIITIVTAWPGIRGAHDLRTRQSGPTRFIQIHLEMEDNLPLVQAHVIADQVEQAILRRFPGSDVIIHQDPSSVVPAAQQGFFER
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SLAA_TRIST
Sequence: MGRFISVSFGLLVVFLSLSGTGADFDCPSGWSAYDWYCYKPFNEPQTWDDAERFCTEQAKGGHLVSIESSGEADFVGQLVSENIQRPEIYVWIGLRDRRKEQQCSSEWSDGTSIIYVNWNKGESQMCQGLSKWTNFLKWDNTDCQAKNPFVCKFPPQC
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec stejaggregin-A subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: CMC4_CANTT
Sequence: MSDEINETCKPQACAIQNCLMKNGYNESKCSYYIDELYKCCKKFYESNGSSASSVCCPKFNLLQLKLKQRELGQIDANLIDTKHG
What are the official names of this protein?
Cx9C motif-containing protein 4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the CMC4 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Imported into the mitochondria via the mitochondrial disulfide relay system.
Protein: ZN490_HUMAN
Sequence: MRRNSSLSFQMERPLEEQVQSKWSSSQGRTGTGGSDVLQMQNSEHHGQSIKTQTDSISLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLACIGEKWKDQDIEDEHKNQGRNLRSPMVEALCENKEDCPCGKSTSQIPDLNTNLETPTGLKPCDCSVCGEVFMHQVSLNRHMRSHTEQKPNECHEYGEKPHKCKECGKTFTRSSSIRTHERIHTGEKPYECKECGKAFAFLFSFRNHIRIHTGETPYECKECGKAFRYLTALRRHEKNHTGEKPYKCKQCGKAFIYYQPFLTHERTHTGEKPYECKQCGKAFSCPTYLRSHEKTHTGEKPFVCRECGRAFFSHSSLRKHVKTHTGVQPYTCKKCGEAFKSSSSCEVHERTHFGEKPYECKQCGKAFNSSSYLQLHERVHTGEKTYECKECGKAFLYSTHFRIHERTHTREKPYECKQCGRVFIYFSHLRRHERSHTGVKPCECKQCGKAFTCLNSLKVHKRIHTGERPFQCRQCGKAFSYSKSLHVHERTHSRQKP
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 490.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NADE_SYNY3
Sequence: MFTIALAQLNPTIGAIAENAEKIVTAALQAQARGADLLLTPELALCGYPPKDLLLNPSFVEQLEEELQWLAEKMPPSIAILVGTVTPHHQAERQGQKKLWNSAVLIEQGQIKQWFHKCLLPTYDVFDEDRYFASAAKSEYFIYKNVKIGVTICEDLWNDEAFWGQKFYQVNPLMDLIDQGVNLVVNLSASPYSCGKHYLRESLISHSAKRFNVPLIYVNQVGGNDDLIFDGGSFAVNSQGKIIGRSPLFQEDLALLSYDLSSGELTGQKLASLPMVDTEELWQALVLGVGDYLHKCGFSKAILGLSGGIDSSLVAAIAVEALGKENVLGILMPSPYSSDHSIQDALALAKNLGMNTQTIPIGPIMATYDQALVPLFQDAPFGLAEENLQSRIRGNLLMAIANKFGHLLLSTGNKSELAVGYCTLYGDMNGGLAAIADVPKTQVFELCRWLNREQTIIPPSVLTKPPSAELKPGQVDTDSLPPYDVLDGILGRLVEKHQSPQEIINAGFEREVVLKICQLVQKSEFKRRQAAPGLKVTDRAFGSGWRMPIAQAFHPQGS
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses L-glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine-dependent NAD(+) synthetase, NAD(+) synthase [glutamine-hydrolyzing].
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD synthetase family.
Protein: RK14_MESVI
Sequence: MIQAQSYLNVADNSGAKKIMCIRVLGGSQRKYAAIGDVIIGVVKDSVPNMSLKKSEVVRAVVVRTCKGIRRENGMTIRFDDNAAVVINKDGNPKGTRVFGPVARELRDRNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL16_SYNJB
Sequence: MLSPKRTKYRKQQRGRMKGKATRGNRINFGEYGLVALEPAWITARQIEASRRAMTRYVRRGGQIWIRIFPDKPVTQRAAETRMGSGKGNPEYWVCVVKPGRILFEMGGVAEPIAREAMRLAAQKLPIKVKFVTKADFEKPEPAQATASEVATSSV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RS141_ENTFA
Sequence: MAKKSKIAKAKKQMAMIEKYADKRQELKAAGDRTALAKLPRDSNPNRLRLRDQTDGRPRGYMRKFGMSRIKFRELAHQGLIPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: IDI2_PYRIL
Sequence: MAIDKRKNDHIYLASSEISQVGSPWFDEVILLHNALPEIDLSEVDITTRFLGVKVNAPFGIGAMTGGTELAGKINAELAKIAEEFGIPIYVGSQRVALMKPEVRWTFEVVKKNAPSVPKVANLGAPQLAELSDEKLAEWVSQAVDMIDAYAIAIHLNAAQEVIQPEGEPRFRGVFEKIKVVRKAAGRPVIVKEVGNGISKEVASRLVEVADAIDVGGYGGTSFIAIEGARAAESGSSMRRRVAEVFKSWGIPTAASICEARSGYRGYIIASGGIRSGLDGAKALALGADFFTMSQPFLKAALEGRLREEIETVIAEVKIAMFLTGSRTIEDLKSAPRVYGPRLRNWIEQRKLVC
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_SALTI
Sequence: MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFIVMGLVDAIPMIAVGLGLYVMFAVA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DDRGK_BOVIN
Sequence: MVSPVVYLVVAALLVGLILFLTRGRGRAAAAAQEPLHNEEVPAAAGRVARPQPLEPEEQRAAGRPRRRRDLGSRLQAQRRAQRVAWADENEEEAIIQAQEEEDIEKPVETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAQEEQAQREHEEYLKLKETFVVVEEGVGETMTEEQSHSFLAEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLIAWGRETPAQAPA
What is the function of this protein?
Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy).  In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets.  Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (By similarity).  Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (By similarity).  Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated transcription.  May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B.  Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (By similarity).
What are the official names of this protein?
DDRGK domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the DDRGK1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum membrane. Note=Localizes to the endoplasmic reticulum membrane in response to endoplasmic reticulum stress.
Protein: MEND_CITK8
Sequence: MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFASHPSQTLSLPRPTQDISARWLVSTLDNVLATLHAGAVHINCPFAEPLYGDMDDTGLAWQQSLGDWWQDDKPWLREARRLESDKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQAACEPEEYWIIDNIEGRLDPAHHRGRRLVAKIADWLELHPAEKRHPWCVDIPRLAEQAWQAVAARRDMFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLISTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPTPQSERERFYLMPQNVHFEHAAAMFNLKYHRPQSWDELDAALAGAWRTPTTTVIELVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: PRM5_YEAS1
Sequence: MTVITIAKRGLPKLTTSTSSTTTASSSSTITSVASSSSSLPLLSNSTSSSIIPSITPPSRNGNPYILDSGDMPNGTVFIVVGGIAGVIFLAILLWWVITTYSSHRLTRSVQDYESKMFSTQHTQFYGDSPYMDYPAKENFQDQVHISESDISPGNKDESVKDALVSHTNNEKPFLSNFERPLSSLVSESNRNSLFISPTGDILYKTRLSKLYQESPRLLQKPVIMTSDNVSTNSLVSTISSSSASSLDNGNEKEVGEDIRKPAKIASSPSRKLLNSPESDGSVNRNHSKGNLLVVQSKRKPTPSTYLEHMLEGKEQDE
What are the official names of this protein?
Pheromone-regulated membrane protein 5.
What is the protein family that this protein belongs to?
Belongs to the PRM5 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ATPG_HELPG
Sequence: MANLRDIRKKIGSVKNTQKITHAMKLVSTSKLRKAEEVARNSRAYALKLDAVFDDVLSKMKNQGIEDIQSKYFRELERLEIKKVDIIFITADKGLCGGFNTNTIKKVLACTNEYKEKDIKVRLRGIGKKGNEYFSFNGIEVLDKINNLSSMPNYERAQEFMKKVVEDYLSGKTDKVIIIHNGFKNMITQEIRVKTILPIGYQIIHQNPQPSEAQETITSEPSGSEDEILDSLAEKYVEYSLYYALIDSLAAEHSARMQAMDTATNNAKDLVKTLTISYNKARQEAITTELVEINAGVEALK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TM41A_MOUSE
Sequence: MRALLGLLLVFGGCTFALYLLSTRLPLGPRLAAAGEPEGRSLWFPSDLAELRELSEVLREYRKEHQAYVFLLFCSAYLYKQGFAIPGSSFLNVLAGALFGPWLGLLLCCVLTSVGATGCYLLSSLFGKQLVISYFPDKVALLQKKVEENRNSLFFFLLFLRLFPMTPNWFLNLSAPILNIPIVQFFFSVLIGLIPYNFICVQTGSILSTLTSLDALFSWETVLKLLAIALVALVPGTLIKKFSQKRLALSETSDIGHPDRRKDA
What are the official names of this protein?
Transmembrane protein 41A.
What is the protein family that this protein belongs to?
Belongs to the TMEM41 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.