PharMolix/UniProtQA huggingface dataset:
Protein: RRF_CLOBK
Sequence: MIKEILKKADEKMGKTIVALKRELASMKAGRANPAMLDRIEAEYYGSMTPLNQLGNISVPEARVLLIQPWDKSALSAIEKAILKSDLGLNPSNDGTVIRLVIPELTEETRKNIVKTVKKTGEEAKVAIRSIRRDCNDDVKNLKKDDVSEDDIKKAEDDIQKKTDKYIKEIDSIISAKEKEILSI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_RICM5
Sequence: MGMSVSHLLIVLLIIFVLFGAGKLPQVMSDLAKGLKAFKDGMKDDGSDNDKNK
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: FIBB_CERSI
Sequence: HDDKAAVDAR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: DOT1_YEAST
Sequence: MGGQESISNNNSDSFIMSSPNLDSQESSISPIDEKKGTDMQTKSLSSYSKGTLLSKQVQNLLEEANKYDPIYGSSLPRGFLRDRNTKGKDNGLVPLVEKVIPPIHKKTNNRNTRKKSSTTTKKDVKKPKAAKVKGKNGRTNHKHTPISKQEIDTAREKKPLKKGRANKKNDRDSPSSTFVDWNGPCLRLQYPLFDIEYLRSHEIYSGTPIQSISLRTNSPQPTSLTSDNDTSSVTTAKLQSILFSNYMEEYKVDFKRSTAIYNPMSEIGKLIEYSCLVFLPSPYAEQLKETILPDLNASFDNSDTKGFVNAINLYNKMIREIPRQRIIDHLETIDKIPRSFIHDFLHIVYTRSIHPQANKLKHYKAFSNYVYGELLPNFLSDVYQQCQLKKGDTFMDLGSGVGNCVVQAALECGCALSFGCEIMDDASDLTILQYEELKKRCKLYGMRLNNVEFSLKKSFVDNNRVAELIPQCDVILVNNFLFDEDLNKKVEKILQTAKVGCKIISLKSLRSLTYQINFYNVENIFNRLKVQRYDLKEDSVSWTHSGGEYYISTVMEDVDESLFSPAARGRRNRGTPVKYTR
What is the function of this protein?
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3.  This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks.  Nucleosomes are preferred as substrate compared to free histones.  Can bind to DNA (in vitro).
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-79 specific, Disrupter of telomere silencing protein 1, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COWA_CONCB
Sequence: QVMVQGDGDQPAARNAVPKDDNPGGEAGKFMNVLRRSGCPWEPWCG
What is the function of this protein?
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa).
What are the official names of this protein?
Contryphan-C, Ca-75.
What is the protein family that this protein belongs to?
Belongs to the O2 superfamily. Contryphan family.
What are the subcellular locations of this protein?
Secreted.
Protein: TAL_PROM5
Sequence: MKSILEQLSSITTVVADTGDLDAIKKFQPRDATTNPSLILAAAKNPDYVKLIDQSLESSRKSLPNGVSESELIKEAIDQVSVFFGKEILNLISGRVSTEVDARLSFDTDATVKKARKLINHYKSFGIDKERILIKIASTWEGIKAAEILEKEGIRCNLTLLFNFCQAVACANAKITLISPFVGRILDWHKVKTGKDNFSGKEDPGVISVTKIYNYFKEKGFKTEVMGASFRNVDEIKELAGCDLLTIAPKFLDELSKEEGELIKKLDENIQSKSSIDYEFDEKDFRLSMLEDQMASEKLSEGITGFSKAIEELEELLLKRFSEINNQKLISAT
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_THIDA
Sequence: MLIIPAIDLKDGHCVRLEQGEMDKATVFSEDPAAMARRWKEHGARRLHLVDLNGAFAGKPVNDAAIQAIVEAVGDEMPVQLGGGIRDLATIERYLDDGVRYVIIGTAAVKNPGFLHEACDAFPGHVMVGLDARDGKVAVEGWSKLTGHDVVDLAKRFEGYGVEAVIYTDIGRDGMLTGVNIDATQRLAQALSIPVIASGGVTNLDDVRGLSAVAKDGIIGAITGRAIYQGTLDFAEAQKLADELAGGVFGV
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2759_LISMO
Sequence: MEITIVKGDITEQEVDVIVNAANSGLLGGGGVDGAIHQAAGPDLLKECQEVINRIGSCPAGEAVITSAGDLKATYIIHAVGPIWKDGEHQEANKLASCYWKALDLAAGKDLTSIAFPNISTGVYGFPKKLAAEVALYTVRKWAEEEYDTSIKEIRFVCFDEENLKLYNKLINSEVV
What are the official names of this protein?
Macro domain-containing protein lmo2759.
Protein: YH05_SCHPO
Sequence: MTPVSSDYRPNHIFLPKFRPDKITSECNTPQQQNVIAEGLYNVSEPFPIRNTDEERYLDTKEIHHTWDNTIKNVVRSIVSIKGSALRSFDTESAGSFCATGFVVNKTLGLILSNRHVVSPGPISARASFINYEEIDIYPIYRDPVHDFGFFRYDPSSIRFHDVTEISLSPESAKVGIDIRIIGNDAGEKLSILSSTLARLDRPAPNYGIDNYNDFNTFYYQAASGTSGGSSGSPVLDISGAAVALNSGGSNSSASSFYLPLDRVVRALRCIENNTPITRGTLLTEFLHWSYDELSRIGLPREFEYDCRTRVPSSTGLLVVSRVLRNSEVSKALEPGDILIAFKTDSHKSTYIVDFVSLFEVLDEMVGKTIELHVYRPKRGFLTFQLTVQDLHNVTPSRFLEVGGAVLHDLSYQLARSYQFSLNSGTYVASSGMLNWSSGTRDFLVTRLANKPTPTLDAFIDVLVQLTDNARVPMHFRVLGKYEEEFTIVTVDRHFFLASIFSRNDEKGTWDRQSLPPPQPSISRRPSVIPRPQEGSKSMEAIQNALVLVHCRMPYSINGFSSTKLYSGTGVIVSVVPPLIVVDRSVIPVDICDIRLTFQSMSAMGHLTFLDNRIAVVSCDYLPSNSVQLNFVADFLRTGDECTLAALDEDLQLLTKKTTVRSVSVVETERSSPPRFRYVNCEVISLMDSLASTGGLVFREVGDDREIVALWISVVHQDVGGKDYTTKYGLSMSYILPVLERLKLPPSARAQHVPTTAGVEWSHITLAGASTLGLSQTRSSEFYMKSRENGTIPRPLYVISHLRPLLHKTSLGVGDILLEVNGKMITRLSDLHEFETESEIKAVILRDGIEMEITIPLYPEYPTFSSRAICWMGAIIHPTHSSVFEQVEPDVDLPGPEGVYVGSILYGSPALNMLRAAHWIVAVDGHDINTFDDFYHMLLEKPTDTFVQVKQMNRRGATSIVSVRPDPLFWPTCIIERDSNGRWCTKHLQRKTKEVCS
What are the official names of this protein?
PDZ domain-containing protein C1685.05.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_CALBG
Sequence: MSNQHTLLTSNLLPVGSNISTWWNFGSMLLTCLMLQITTGFFLAIHYTANINLAFSSVIHITRDVPYGWIIQNTHAMGASMFFICIYMHIARGLYYGLYLNKMVWLSGVSLLITLMATAFFGYVLPWGQMSFWAATVITNLLTAIPYLGTVVTTWLWGGFSINDPTLTRFFALHFILPFIIISLSSIHIILLHNEGSNNPLGTNSDTDKIPFHPYHSYKDMLMTTILISILFYILSFTPNLFNDPENFTKANPMITPQHIKPEWYFLFAYGILRSIPNKLGGALALLLSIIILTSAPFTHTSHTRSMMFRPLAQILFWILATAFITITWTATKPVEPPFITISQWTSTLYFSFFMINPMLGLIENKITNTNTNT
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YG045_HUMAN
Sequence: MGWVIPEWPGAQSCPTAAQVAQPVPFMCNAPASPINDKEKDKAGGRLPSGSEPRARAFCEAGADGEQGDPSPADTIKANQGHIPAAPGETGSVICWCDQSVAPPRPAGLSVSGRQSYLVGCFRWVLTFFFSVFYLTP
What are the official names of this protein?
Putative uncharacterized protein FLJ40140.
Protein: FADB_ECOL5
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIGLVDGVVKAEKLVEGAMAILRQAINGDLDWKAKRQPKLEPLKLSKIEAAMSFTIAKGMVAQTAGKHYPAPITAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDVETPKQAAVLGAGIMGGGIAYQSAWKGVPVVMKDINDKSLTLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPDTVLASNTSTIPISELANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKDYRDAIDALFNANRFGQKNGLGFWRYKEDSKGKPKKEEDVVVDDLLAKVSQPKRDFSEEEIIARMMIPMVNEVVRCLEEGIIATPAEADMALVYGLGFPPFHGGAFRWLDTLGSAKYLDMAQQYQHLGPLYEVPEGMRNKARHNEPYYPPVEPARPVGDLKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: METK_SALA4
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILQQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPVTYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHAEDIDQKSLQEAVMEEIIKPILPSEWLNTSTKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPAEQLILLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGRENFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F172A_HUMAN
Sequence: MSISLSSLILLPIWINMAQIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALGEIITKYVYELLEKDCNLKKVSIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPFIKRAVAEGYGVIVLNPNENYIEVEKPKIHVQSSSDSSDEPAEKRERKDKVSKETKKRRDFYEKYRNPQREKEMMQLYIRENGSPEEHAIYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWKSFPSIFKFFTEASEAKTSSLKPAVTRRSHRIKHEEL
What is the function of this protein?
Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7.  Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface.  May have hydrolase activity.
What are the official names of this protein?
Cotranscriptional regulator FAM172A, Protein FAM172A.
What is the protein family that this protein belongs to?
Belongs to the FAM172 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum.
Protein: ASSY_SHEB8
Sequence: MSIEIKNTGVKKVVLAYSGGLDTSAIIPWLKENYDNCEIIAFCADVGQGEEELVGLTEKALASGASECHIVDLKEEFVKEYIYPTIASGAIYEGTYLLGTSMARPIIAKAQVEVARKVGADALCHGCTGKGNDQVRFEGCFAALAPDLKVIAPWREWTMQSREDLLAYLAERDIKTSASATKIYSRDANAFHISHEGGELEDPWNEPSKGVWTLTADPEDAPNKPEYVSLEVEHGRITKVNGEALTPYAALMTLNAIAAPHGVGRIDITENRLVGMKSRGCYETPGGTVMFAALRAIEELVLDKTSRNWREQVAAQMAHLVYDGRWFTPLCKSLLAASESLAESVNGEVVVKLYKGQATAVKKRSPNSLYSEAFATFGEDQVYDQKHAEGFIRLYSLASRIRALNANDVKSK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AL3A2_PONAB
Sequence: MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILAAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKMLAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFMLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY
What is the function of this protein?
Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids.  Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length.  Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
What are the official names of this protein?
Aldehyde dehydrogenase family 3 member A2, Fatty aldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: PROA_MYCTU
Sequence: MTVPAPSQLDLRQEVHDAARRARVAARRLASLPTTVKDRALHAAADELLAHRDQILAANAEDLNAAREADTPAAMLDRLSLNPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQQRVPLGVVGMIYEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLELPADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTIETGVGNCHVYVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAETALPRLLAALQHAGVTVHLDPDEADLRREYLSLDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_MYCA1
Sequence: MPRSLKKGPFVDGHLLKKVDAQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPVFVTEAMVGHKLGEFAPTRTFKGHIKDDRKAKRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: RSMA_YERPP
Sequence: MNNRVHQGHFARKRFGQNFLNDQFVIDSIVSAIHPVPGEAVVEIGPGLGALTEPVAARMDHMTVIELDRDLAARLASHPQLKDKLTIHQQDAMKVNFSELSEQAGQPLRVFGNLPYNISTPLMFHLFSYTDAIRDMHFMLQKEVVNRLVAGPNSKTYGRLTVMAQYYCNVIPVLEVPPTAFTPAPKVDSAVVRLIPHVQMPHPVGDVRMLSRITTQAFNQRRKTVRNSLGDLFTSEQLIELGIDPILRAENISVAQYCKLANWLSAQSTPQK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTC5_KOMPG
Sequence: MGQSVSSEEETKQDYRTVKVSKGQLQRLFDKNCLSLLTPIEVYSLKENLHVRDINNDKQLSIDETVQLLGLPKDCPCNEVVYDFVRVLGWFPFFNSVDPLKGISLPMLIRSVVLSRSKSFFKLFKGDSSYKFEDLVFLVLSILSEPKDLVEKNLDSSCDETGVLELALQGDSNIHWAQCKVIKDFDNTNIKERKVSAYNLAIFLTFLLAISRPLMSDYSQHLSQWSNFMSHGMNLVRSFDSSITERSLHSKTVGYAAFISTIETKMPNVLHPLDALLDSLLFMKQSKGASDVTPEFSVSTKLINEYSLAQLSTVLPLELCYSRLRKLYVGSESGFSMRSFESKCFNWNAPTITFISGHRITSKKTKRYLLFEEQFPRSRAAEDETGSDFDHANDDSARLTFAVFLNQHWKTSNKEPFGDSKTTIFQLSPRQAVFKSSTFRKDYCYFNTSGGGIGFGNEEPYLKNNTTKFRPGNVSLTIDSGLEFCVFRHLGKGGSFNPMVLEDDSIPVYEDRFVISDLEVWGCGSEKELLEQAKRWAWEEKEAMARQRINADTLGEERAFLEMAGLVGNHGASGGSV
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 5.
What is the protein family that this protein belongs to?
Belongs to the RTC5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM1_HALS3
Sequence: MDVSEGGVTVSVPTASGGGEGAADDVFFNATQELNRDLTVATLAAFREREPRAASYLDAMTASGIRGVRAANAGWDVTMADVDADAVELATSNLARNGLDGEVVARDANSLLHDHDRVLDVVDIDPFGSPMPFADAAFANARNLVCVTATDTAPLCGAHFESGVRKYSATPRNTNYHAEMGLRILLGALARTAARYDVGVTPILSHVSDHYVRTYLELDHRATDANAAVEQVGHVYHCQQCLSRDHEYGLVAAPRAECPRCGGHQVLTAGPLWLGPAHEEAFAASVREQLTREMGEASQAFHLLQTIEGELHEPTHYDQHRLYSQWGEPAVGMAEFLDQLRDAGLRASRTHFGGTTFKTDGGLAEVEAAVL
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: NFE2_HUMAN
Sequence: MSPCPPQQSRNRVIQLSTSELGEMELTWQEIMSITELQGLNAPSEPSFEPQAPAPYLGPPPPTTYCPCSIHPDSGFPLPPPPYELPASTSHVPDPPYSYGNMAIPVSKPLSLSGLLSEPLQDPLALLDIGLPAGPPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVEMYPVEYPYSLMPNSLAHSNYTLPAAETPLALEPSSGPVRAKPTARGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLTNERERLLRARGEADRTLEVMRQQLTELYRDIFQHLRDESGNSYSPEEYALQQAADGTIFLVPRGTKMEATD
What is the function of this protein?
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation.  Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR).  This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters.  Requires MAFK or other small MAF proteins for binding to the NF-E2 motif.  May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
What are the official names of this protein?
Transcription factor NF-E2 45 kDa subunit, Leucine zipper protein NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. CNC subfamily.
What are the subcellular locations of this protein?
Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
Protein: UBI4P_NEUCR
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: T185A_HUMAN
Sequence: MNLRGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVGTGVWARNPQYRAEGETCVEFKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSVAACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHWPWLVVCVPLWILMSFLCLVVLYYIVWSVLFLRSMDVIAEQRRTHITMALSWMTIVVPLLTFEILLVHKLDGHNAFSCIPIFVPLWLSLITLMATTFGQKGGNHWWFGIRKDFCQFLLEIFPFLREYGNISYDLHHEDNEETEETPVPEPPKIAPMFRKKARVVITQSPGKYVLPPPKLNIEMPD
What are the official names of this protein?
Transmembrane protein 185A, Protein FAM11A.
What is the protein family that this protein belongs to?
Belongs to the TMEM185 family.
What are the subcellular locations of this protein?
Cell projection, dendrite. Membrane; Multi-pass membrane protein.
Protein: SMCO2_MOUSE
Sequence: MMSLQLGTAGKERQLAEKSRDLQNVSMTEGSEEVSEMDHISDRPDEKDKPSENLQTDSLYKMDTEKWDGLEQESEHSQDPPSKPDEQEVTLVCEGPQVSQLSPSTDESTPIPESLTHKLNYWHAKMGLQMKELGADHGDWLERINNIIQNINNTESTVKSLLTEVISLENQSKNLEDSDQEADIEEKITEIRRQLKEVNIKLTQVDACEEARELKEKLVEQIESFHKEMNVLNSKLEMYYTQGSDADSHNSEDVDTEQEEPLVPEASPSLSASPTPPCSAVWKNALKLFVIVYVVTITGLSCYILFVDATFLFERVLPSVLGHRTMWDLREMMAPFLNLEAEDLLPS
What are the official names of this protein?
Single-pass membrane and coiled-coil domain-containing protein 2.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.