PharMolix/UniProtQA huggingface dataset:
Protein: DAB_DROME
Sequence: MVKSLVAKLSTASSNLSLASTFGGGSGAAEETNYAKHRNDPGRFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVFELKKKEIEMARQQIQGKSLHDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTTSSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPDAVTSLDAMLSPPPGTSSSHGSASAGLQAADNDDDNWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTATPTQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQELKNPPKKLLKELSSGSQAGLGLGLSLGQLDGLFPEDSTTISTTTTTATNITAGNPQQNSANTLTSTASTAASLGQLLSTVALNPDPLPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPPTLNSLENPHPPADPVLLPRDTDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSIPNLATETKANVFNGPLQVQLPPEKELQLQQPPSTVRNRPTASVSALPSGGALDVISSISNKKMPHLFGQARSFGKSGSDIGSSVNMRRLQESDSLSETEAAPEPPPRPDSTPYSEPPPLPPKKQFSDLVIRPSPANTTQPPTSGRYEYLNSNVTARRTASSVDAPPIPLPSRRVGRSDGCFPGPGRPRKPGHTEDDYLAPLGAPPPLLPPPSQGSSARARPQRQASLGRPQDIYENKAEILQAQAQAQAQAPEVAPSSNTLAPDITLTQLLTLGMDDLAIKLNVPASKLSTMTLVQLTAYLSEYLSSEKSQVHSQERRSSPANTAPAPASTAAVFKVNFDQQTSFVAKFDDTFGEDEPVMPSGSSDSTFVANFANFNDAPTPVPTVSPVVATVPSADRYAVFREIIDQELQQQQQETDLMGDLTPPPVDETQAKEISEGLEVNNVGAELPIDALDVKPAPKIDTKITEVVAQAKDRYAALRDIILVENLFDKPAIATDTQPEKEKDLLQDFPEFSDEFNEDHDLRQIMDHQNVQTHARDRHGLVDSRGFPTEPSSSALTVGDYDEDEDADAGGESSLDSNEKDAEPVSGQDQYEKLSTSTQQLDAAAPALEDVQQLQQQSLPPKQDQKFLSILTAPGGGTKDDIEIDELMHRAISNLSLDSRDRVSPATSSAAPSRGAPGLHTPSQFNDVSTSPIPLQKPGMGPSPVPSQLSAVSQLIDTATKQMMGDKDREKQSWATFDSPKAKGKARLTLPPPPPPASNTSQPDTVESPCSSDPRDDGWSKQQRRWAKKERQQTSSSSRDLSPWDDETPEYLKRRQLAAAQMAHPHQPPMQAPPQHTDRHGYYMRHARRMNSCDEDYDYDGEFVARRDQPQHQQQQRKFKHGLSRSRDNFELESPSWYHHPAHHTWSPQEIEQVRVRSFDRTAYERSSYGPPPPIYDKRGQLRGKYRGDHRDRERERDRDREYRDYARPSYDFDYENVYEERGGRSPLAYKPGRGGGDYLYDRERDRDRERDRKSFDRESLESYESATRRRRSFGSGNDVYGSLDSRDDYRGDRERDRERDREQMKTRSLRKPTTTSGKLRISGDIDYEQDSEQDFQQRSGVRSLQRPNQLGGDVVLPSNAVVGPQRLRKSSGSSPWDGEEPALPGQKSWKRPASAAETERRLAESRRAVALGQTPSDGEKERRFRKKTRARSAKDLATVGAPSASTSAPSRSSYGRGIRDNYDYICPGQRNDDDDDDDEDYVDDEPPTDEDKFERLNRRRHEMHQRMLESERRQMERHQPPSLAKLPGQNRTRGVVANSDYGFVDSYEQTPTPTPRSNASSTGPGGLMMSGGESSAGVTSSKFNFDDGFESDFNQSSPPPAPAGTASSCNSTPAGPVSANANNGGSKSLFRFSNDFSDREKREQFEMDTPPTSTPPITQKLRFDDNVKVSQFDDAAFEDDFAKASFDFEKEQAGSATAGAGGSGAMSRKQNMRTSKLQQRQELIKKSESVNIFAKKQEDPFEDDEFFKSPDQEQAMDQHNDDTEGGKFQWSEDANFAKFDENM
What is the function of this protein?
Together with Abl, involved in embryonic neural development.  May have a role in eye development.  Acts as an adapter protein for SH2-domain containing proteins during sevenless (sev) signaling.
What are the official names of this protein?
Protein disabled.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM42_PONAB
Sequence: MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYNCSVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEHLEEGPMIEQLSKMFFTTKHRWYPHGRCRKNLNPPKDR
What are the official names of this protein?
39S ribosomal protein L42, mitochondrial, L42mt, MRP-L42, 28S ribosomal protein S32, mitochondrial, MRP-S32, S32mt.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL42 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CITH_KLEPN
Sequence: MPTARCSMRASSTAPVRMMATAGGARIGAILRVTSGNFLEQFDFFLFGFYATYIAHTFFPASSEFASLMMTFAVFGAGFLMRPIGAIVLGAYIDKVGRRKGLIVTLSIMATGTFLIVLIPSYQTIGLWAPLLVLIGRLLQGFSAGAELGGVSVYLAEIATPGRKGFYTSWQSGSQQVAIMVAAAMGFALNAVLEPSAISDWGWRIPFLFGVLIVPFIFILRRKLEETQEFTARRHHLAMRQVFATLLANWQVVIAGMMMVAMTTTAFYLITVYAPTFGKKVLMLSASDSLLVTLLVAISNFFWLPVGGALSDRFGRRSVLIAMTLLALATAWPALTMLANAPSFLMMLSVLLWLSFIYGMYNGAMIPALTEIMPAEVRVAGFSLAYSLATAVFGGFTPVISTALIEYTGDKASPGYWMSFAAICGLLATCYLYRRSAVALQTAR
What is the function of this protein?
Uptake of citrate across the boundary membrane with the concomitant transport of protons into the cell (symport system).
What are the official names of this protein?
Citrate-proton symporter, Citrate carrier protein, Citrate transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TX36B_PHONI
Sequence: MKVAILFLSILVLAVASESIEESRDDFAVEELGRATCAGQDQTCKVTCDCCGERGECVCGGPCICRQGNFLIAWYKLASCKK
What is the function of this protein?
Reversible inhibitor of voltage-gated sodium channels (Nav).  Delays the fast inactivation kinetics of neuronal-type sodium channels.  In vivo, it induces rat penile erection (PubMed:15246765).  This effect may be due to the neuronal nitric oxide synthase (NOS1), since one of its selective inhibitor completely abolishes all the toxic effects of the toxin (PubMed:15246765).  This toxin also causes scratching, lacrimation, hypersalivation, sweating and agitation followed by spastic paralysis of the anterior and posterior extremities and death at dose levels of 0. 24 mg/mouse (PubMed:1397265, PubMed:16278100, PubMed:15246765).  It is also insecticidal to the larval and adult forms of the house fly (PubMed:1397265).
What are the official names of this protein?
Delta-ctenitoxin-Pn2c, Delta-CNTX-Pn2c, Neurotoxin Pn2-5A, Neurotoxin Tx2-5, PnTx2-5.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 03 (Tx2) family. 06 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RUVC_BURPS
Sequence: MRILGIDPGLRVTGFGVIDVSGHQLAYVASGVIKTPTADLPTRLGTIYDGVSTLIREHTPDQAAIEKVFVNVNPQSTLLLGQARGAAICGLVSGGLPVAEYTALQLKQAVVGYGRATKEQMQEMVARLLSLSGRPGTDAADALGMAICHAHGGNTLNTLGGIAPALAKKGLRVRRGRLVG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: AMPS2_LITPI
Sequence: KPKEDREWEKFKTKHITSQSVADFNCNRTMNDPAYTPDGQCKPINTFIHSTTGPVKEICRRATGRVNKSSTQQFTLTTCKNPIRCKYSQSNTTNFICITCRDNYPVHFVKTGKC
What is the function of this protein?
Endonuclease, hydrolyzes highly polymerized RNA, poly(U) and poly(C), and the dinucleotides CpA and UpA.  Hydrolyzes 18S and 28S ribosomal RNA.  More active towards rCA than rUA or rUG.  Has cytotoxic activity against cultured human submaxillary gland carcinoma cells.
What are the official names of this protein?
Amphinase-2.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: BETA_BRUA4
Sequence: MEADFVIIGSGSAGSAMAYRLSEDGRYSVIVIEYGVPDVGPLIQMPAALSFPMNMETYDWGFSTEPEPHIGGRSLVTPRGKVLGGSSSINGMVYVRGHARDYDHWSESGARGWAYADVLPYFKRMENSSGGQEGWRGTNGPLYIQRGKRDNPLFHAFVEAGHEAGFEVTEDYNGEKQEGFGPMEQTIHNGRRWSAANAYLKPALKRPNVKLVKGLARKIVLEGKRAVGVEIEAGRSFSTIRARREVIIAASSINSPKLLMLSGIGPAAQLKEHGIEVVADRPGVGQNLQDHLEVYIQQECTQPITLYSKLNLFSKAKIGAEWLFFKTGDGATNHFESAAFLRSKAGVEYPDIQYHFLPVAIRYDGKAAAQSHGFQAHVGPMRSKSRGSVTLRSANPREKPVIKFNYMSHEDDWADFRHCVRLTREIFGQAAFNPYRGAEIQPGAHVQSDDEIDNFIKEHVESAFHPCGTCKMGAVDDPMAVVDAECRVIGVEGLRVADSSIFPRITNGNLNGPSIMVGEKASDHILGRTPLARSDQEPWINPRWQVSDR
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: RSMA_ECODH
Sequence: MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAENAPLQES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_CELJU
Sequence: MSEYSVFTSESVSEGHPDKMADQISDAVLDAILTDDPNARVAVETLVKTGMAIVAGEVRTSTYVDLEDLIRQVILDIGYNSSDVGFDGASCAVLNAIGKQSADIAMGVDEGDQKDLGAGDQGLMFGYATNETAVLMPAPIFYAHRLVEKQAQLRKSGELPWLRPDAKSQVTLRYENGKPVAVDAVVLSTQHSPSVQQAEIHEAVRELIIKNVLPAEWLHKDTQYHINPTGQFIIGGPVGDCGLTGRKIIVDSYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLADKCEIQVSYAIGVAEPTSISINTFGTGKLPDAEIIKLVREHFDLRPRGLIEMLNLKRPIYRQTAAYGHFGRELPDFTWEKTDKADALKKAL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_NOSS1
Sequence: MDVIPAIDLLAGRCVRLYQGDYDRSQVFSENPVDVAKQWVDEGATRLHIVDLDGAKAGKVVNLGAIEAIAQAISIPIEIGGGLRDRSSVEQVFNLGVQWAILGTVAVEQPQLVQELCQQYPGQIIIGIDARNGLVATRGWLETSEVLATQLAIQMQEMGAAAIIYTDIHRDGTLAGPNLDALRELAAAISIPVIASGGVSSVTDLLSLLALEPQGVTGVIVGRALYTGDISLKEALQAIGPGRIQDIPPNLDFSSFA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SX5_OXYMI
Sequence: MKTLLLTLVVMTIVCLDLGYTLTCYMNPSGTMVCKEHETMCYRLIVWTFQYHVLYLKGCSSSCPGGNNCACCSTDLCNN
What are the official names of this protein?
Toxin 3FTx-Oxy5, Three-finger toxin, 3FTx.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_VIBA3
Sequence: MSLNAETKAAIVAEYAQSEGDTGSPEVQVALLTASINHLQGHFKAHKHDHHSRRGLLRMVSSRRKLLDYLKGKNLTRYQDLIKRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RLMH_BURMS
Sequence: MKLHIVAVGHKMPGWIASGFDEYAKRMPPELRIELREVKPELRSGSRTADSVMAAEQQRIEAALPKNARVVALDERGRDWTTMQLAQALPAWQQDGRDVAFVIGGADGLAPALKSRAELLLRVSSLTLPHGMVRVLLAEQLYRAWSITQNHPYHRA
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOF_ESCF3
Sequence: MSWQEKINAALDARRTADALRRRYPVAQGAGRWLVADECQYLNFSSNDYLGLSHHPDIIRAWKQGAEQFGVGSGGSGHVSGYSVAHQALEEELAEWLGYSRALLFISGFAANQAVITAMMAKEDRIVADRLSHASLLEAASLSPAQLRRFTHNDVAHLARLLASPCPGQQLVVTEGVFSMDGDRAPLAEIQQVTQQHNGWLVVDDAHGTGVIGEQGRGSCWQQQVKPELLVVTFGKGFGVSGAAVLCSNTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRGEEGDARREKLAVLITRFRAGLQGLPFTLADSRSAIQPLIVGDNARALHLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHETQDIDLLLEVLHGNG
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: UPPP_NEIG2
Sequence: MDFLIVLKALMMGLVEGFTEFLPISSTGHLIVFGNLIGFHSNHKVFEIAIQLGAVLAVVFEYRQRFSNVLHGVGKDRKANRFVLNLAIAFIPAAVMGLLFDKQIKEYLFNPLSVAVMLVLGGFFILWVEKRQSRAEPKIADVDALRPIDALMIGVAQVFALVPGTSRSGSTVMGGMFWGIERKTATEFSFFLAVPMMVAATAYDVLKHYRFFTLHDVGLILIGFIAAFVSGLVAVKALLKFVSKKNYIPFAYYRIVFGIVIIILWLSGWISWE
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS8_XANC8
Sequence: MSTASVMDLVRDDLRAFAGYASARTSALQGDVWLNANESAWGNPADPDASTRRYPDPQPKGLRAALAQLYGCAPEQLLIGRGSDEAIDLLVRGLCVPERDAVVVTPPVFGMYAVCARLQNAPLVEVPLVDGADGLHADVPAIVQAALDAKAKLVFLCSPSNPAGSAIPLAEIEAALQALQGKAVVVVDEAYGEFSDVPSAIGLLARYDNLAVLRTLSKAHALAAARIGSLIANAELIALLRRCQAPYPVPTPCAVMAEQALSAPALAVTQRRVTEIRAERARLHAALVQVAGVRQVYPSQGNFLLVRFDDAEAAFQALLEAGVVVRDQRAVPRLSDALRITIGTPDQNDRVLGALQRKQEAA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: Y1456_STAAC
Sequence: MKNYSFYQFVMTVRGRHDDKGRLAEEIFDDLAFPKHDDDFNILSDYIETHGDFTLPMSVFDDLYEEYTEWLKF
What are the official names of this protein?
UPF0346 protein SACOL1456.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: Y2680_GEOSW
Sequence: MGEPILFLLILFIIGFIAKNQSLMIAVAILLIIKMVGMGEKWLPIVHEKGIHWGVTVITIAVLAPIATGEIGFRQLIASLQSLSAWIALLSGIFVALVAKGGVTLLATDPHMTAALVFGTIIAVSLFHGVAVGPLIGAGIAYMVMKVIEYF
What are the official names of this protein?
UPF0756 membrane protein GWCH70_2680.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 5HT2A_PONPY
Sequence: MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFSLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEDASKDNSDGVNEKVSCV
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores.  Affects neural activity, perception, cognition and mood.  Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances.  Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Cell projection, dendrite. Presynapse.
Protein: PRO_ADECU
Sequence: MAEGGSSEEELRAIVRDLAVTPFFLGTFDKRFPGFISSQRITCAVVNTAGRETGGVHWLAMAWNPRSKTFYMFDPFGFSDSKLKQVYSFEYEGLLRRSAIASTPDRCVTLAKSNETIQGPNSAACGLFCCMFLHAFVNWPDNPFNHNPTMGPLKSVPNYKLYDPTVQHVLWENQEKLYKFLEKNSAYFRAHAAAIKTRTAFNKLKQ
What is the function of this protein?
Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions.  Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors.  Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating.  Without maturation, the particle lacks infectivity and is unable to uncoat.  Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction.  Cleaves host cell cytoskeletal keratins K7 and K18.
What are the official names of this protein?
Protease, Adenain, Adenovirus protease, AVP, Adenovirus proteinase, Endoprotease.
What is the protein family that this protein belongs to?
Belongs to the peptidase C5 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Present in about 10 copies per virion.
Protein: PTHP_HALVD
Sequence: MERTVTVVPEDGLHARPASKFVETANKFDADVQLGRADEDDLVPAASMLAVTGLGVGHDESVRLVAEGDDAEAALDALEDILSTPEAKQ
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I.  Phospho-HPr then transfers it to the PTS EIIA domain (By similarity).  Is involved in fructose transport.
What are the official names of this protein?
Phosphocarrier protein HPr.
What is the protein family that this protein belongs to?
Belongs to the HPr family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BVGA_BORPA
Sequence: MYNKVLIIDDHPVLRFAVRVLMEKEGFEVIGETDNGIDGLKIAREKIPNLVVLDIGIPKLDGLEVIARLQSLGLPLRVLVLTGQPPSLFARRCLNSGAAGFVCKHENLHEVINAAKAVMAGYTYFPSTTLSEMRMGDNAKSDSTLISVLSNRELTVLQLLAQGMSNKDIADSMFLSNKTVSTYKTRLLQKLNATSLVELIDLAKRNNLA
What is the function of this protein?
Member of the two-component regulatory system BvgS/BvgA.  Activates the transcription of virulence genes.
What are the official names of this protein?
Virulence factors putative positive transcription regulator BvgA.
Protein: ECFA1_OENOB
Sequence: MKIIETKNLNYSYTQSSIRSIENVNFSVLDGEWITIVGKNGSGKSTLIRLLDGLLKADSGKIIIDGLTLSEKTLWEIRKKIGIVFQNPDNQFVSGSVIEDVAFGMENYQIPQEEMLVRAQQALKTVGMIDFAEKSPVRLSGGQKQRVAIAGVLAIQPKILILDEAASMLDPDGRDEVWQTIKKLKEQQNLTVISVNHDLNELNLSDRVILLNDGKIAADTKINQLFSDSELLSKNDLKLPFLQQLQKDLRESGINFTQEYNHQRELVNFLWKSISGT
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GH_MUHVS
Sequence: MKLSLILSIALCSTRVVYAAGAEAPRISRNTVKLHSYNESRVCRHDESSNQTVSHAAMFTFNFQDGDGYRVYQVPRCLFNTHAAREVLSSVDMTETLESYRKRFRVYFVVPIYGAYRLVARSPTAKYPGGVLNPPPASSVTMQDLIVDATNIHTVVPDKLCVITEHPVIFSMKVPCSHQVITWTGYTVTVSLAQKFFVLTIKPTRDHTSENTLAMFFGDVREVDLKAPYTVGAFLLRQTPDHDLLVVVKQTAFIQRYMFLTDVVFLQRTLSADYADTSVCLRVLSVLASVVARGKQCGLITRDTVEFFFTYSLCQLMANGTRYQSTAPVSTALWRQSELELFGEFIRHCFKTTTPNPTPAFQTRMQLTEKHKPAHSSNAIDVRVLAATYSSGMHAASMADLAFLLRSTRIPPNVNTDALLQKLLFTTDAYYRMSLKIPLSGSMRRILIRVDLTVRTQLNESSVARRHFVLLTSMCSPREQISWGELLMNPQRGAPSEIYSPCVSGGRRDYTGPSVRALMESAHRPERRAEQVMSVTEALRPKRSQMSDEANCVPDSTQGAVITANEKTYLISSDFIVKGLAIPVSNTVVDRNLMITVLDRRSPCVLSRSYRERGSVIVMNNITFTERCEFCASTLVEYDEVDGLTSIMHIPSIEVLKYLTDPENDILVATPRVHYLLLTANGTVFEVTDILVNVRPSMPYSVVVALVIIAILMALGLYRLCRQKR
What is the function of this protein?
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell.  Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL.  May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
What are the official names of this protein?
Envelope glycoprotein H, gH.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein H family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: HYSA_THECX
Sequence: MSWNRRSFLGALGVTCLAGAGMVPIVRPRTAAAADEFDLLRERWCSLVTGSGYDPDVEPFKSRLAALGAEAEQYLTTLAPGETSLWPDLPLDTSTWNMTLSARRLRTMAVAYLVPGTGHTGNSAMAEAAVTAFDELTTRFYAPPHWWGNWWDWLIGTPQALNDFCALLYEQLGPELIDRYVQRVDHYVDPGAIDRTTGANRGWLCEVTAVRGVLGKSPEMMAKARDGLSPIMVYVTDGDGFYRDGSFIQHEYYAYTGSYGISLLQSVSGLFALLAGSTWEIVDPNRQVLFDSIENSFAPFVYNGLLMDAVAGRVISREAEHDHWRGHLLAASVLRMAEAGSPEEAKRWRGIVKGWLLRESEPRYMGDQTLTMAAVADAQAVLDDPTIEPLPEPVEHRIFAAMDQAVHRRPTWAFSISMRSVRTAFYETINGENLKGWHTGVGMTYWWGADFGNDHYTDGFWPTADPYRLPGTTVSRKPLEDGVGNNVLPTEAWAGGTTDGEFAAVGQSIQALESTLRGRKSWFCLDDAVVCLGAGITCADGYAVDTTVDQRNLGENGVHDFRLNGIPSPTSGTWSLTVPNARWAHLEGFGGYVFPGGARVSAIRETRTGSWYDINVGGPRDELRRRYVTVYLDHGVDPVDASYVYLVMPGATRQETIRRAADRRWLRVLANTADRQAISVPSLGFVGANFFAPGTVDALTVDQPCSVLVRVADGRATICVSDPRQDGSTVRVTWNRPVASVVSSDPTVRVVEAGERLVLDVTVEETAGMTQRAVVALA
What is the function of this protein?
Degrades hyaluronic acid into unsaturated disaccharides as the end products (PubMed:33561520).  Exhibits very low activity against various types of chondroitin sulfate variants (PubMed:33561520).
What are the official names of this protein?
Hyaluronate lyase, Hyaluronidase, HYase, TcHly8B.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 8 family.