PharMolix/UniProtQA huggingface dataset:
Protein: NEK8_HUMAN
Sequence: MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP
What is the function of this protein?
Required for renal tubular integrity.  May regulate local cytoskeletal structure in kidney tubule epithelial cells.  May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity).  Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
What are the official names of this protein?
Serine/threonine-protein kinase Nek8, Never in mitosis A-related kinase 8, NimA-related protein kinase 8, Nima-related protein kinase 12a.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.
Protein: RISB_DEHMC
Sequence: MGKEFSGVLNGQGLKIALVVSRFNEFITSKLLSGAKDSLERHGVSADNTDVAWVPGAFEIPLVAQKLAKSGRYDAVVCLGAVIRGSTPHFEYVSSEVSKGIARVGLDAGLPVIFGVITADSIEQAIERAGTKMGNKGFDAATQAIEVANLMKNLT
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: YAML_STRVL
Sequence: GDVSVVGFDDSPLIAFTSPPLSTVRQPVQAMATAAVGALLEEIEGNPVQRTEFVFQPELVVRGSTAQPPGRVSQVLS
What is the function of this protein?
Putative sugar-binding regulatory protein for the alpha-amylase gene.
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator in aml 5'region.
Protein: THIE_BACAH
Sequence: MSRISKAEMSKLLSVYFIMGSNNCTKDPLQVLREALEGGITIFQFREKGEGALTGEERICFAKELQAICKEYGVPFIVNDDVELALELDADGVHVGQDDEGITSVREKMGDKIVGVSTHTIEEARWAIENGADYLGVGPIFPTSTKKDTKAVQGTKGLAHFREQGITIPIVGIGGISIENTASVIEAGADGVSVISAISLAESSYESTKKLVEEVSRSL
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: NOD2_HUMAN
Sequence: MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLHGCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTYDGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLGCRDTRLLL
What is the function of this protein?
Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity (PubMed:12527755, PubMed:31649195).  Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling (PubMed:11087742, PubMed:21887730).  This in turn leads to the transcriptional activation of hundreds of genes involved in immune response.  Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).  Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199).  Also plays a role in sensing single-stranded RNA (ssRNA) from viruses.  Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189).  Besides recognizing pathogens, participates in surveillance of cellular homeostasis through sensing and binding to the cytosolic metabolite sphingosine-1-phosphate and then initating inflammation process (PubMed:33942347).
What are the official names of this protein?
Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Membrane. Mitochondrion. Basolateral cell membrane.
Protein: LGT_ANAMM
Sequence: MSGMSICFAMREAVEWILHLDPVFMHVGPLEIRWYALSYVFGILFAHWHITKASQCLALDKKFLDSLMLWAVIGIILGGRTAYILLYNPSFYWEYPSEILQTWHGGMSMHGGYVGCIIAVSIVCKKHRVRVMPVLDLCACAAPLGLFLGRMANLVNGELYGRATTTCLGVVFPSSGDLVPRHPSQVYEAMLEGLLPLLFMSILARYTKVRLRFGVLSHMFGAWYGIVRCAVEFFREPDPQVGYIAFGWLTMGQVLSAPIAVVGIFMLVLTVLREKPREGVADISA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYL_XANC8
Sequence: MSTVEPNAYDPQQVETSAQQFWDATRAFQVDENSDKPKFYCLSMLPYPSGALHMGHVRNYTISDVVSRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAKWTYANIEHMRAQLKSLGYAIDWSREFATCTPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPIDQTVLANEQVIDGRGWRSGALVEKREIPQWFLRITDYAQELLDGLDQLDGWPDSVKTMQRNWIGRSEGLEIQFDVRDTTGAALDPLRVFTTRPDTLMGVTFVSIAAEHPLAQHAAKSNPELASMLETLKHGGVSEAELETQEKRGMATGLTAVHPISGEEVPVWVANFVLMGYGTGAVMAVPGHDQRDFEFANKYGLPIVQVVKLREPRNDDEQAWDATQWRDWYTDKSRELELINSAEFDGLDYHGAFEALAERFERKGQGQRRINYRLRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEDQLPVVLPENVEFAGTGSPIKTDPTWRQTTCPECGGPAERETDTFDTFMESSWYVARYTSPNARDMVDRRANYWMPADLYVGGIEHAILHLMYFRFYHKLMRDARLVDSDEPVTNLLTQGMVIAETFYRDADNGGKDWINPADVEIQRDERGRVVGASLIADGQPVHIGGTEKMSKSKNNGVDPQAMVAKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARFMRRLWVQVHKHVGEGAAALDVASLSAEQKAIRRKTHETIGKVDDDYGRRHSFNTAIAAVMELSNALAKFDDASAQGRAVRQEALEAMVLLLNPITPHASHALWQVLGRGETLLENVPFPQVDAAALVRDALTLAIQVNGKLRGTIEVAADAAREQIEALALAEPNAAKFLDGLSVRKIIIVPGKIVNIVAG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DF146_ARATH
Sequence: MMKNQFQLSLIILTFFILLELGVMGNVQQVKREQCHTVIPNKSGKCIFTECKSACEKLKKPVASLCLPPKTCRCYHFCS
What are the official names of this protein?
Putative defensin-like protein 146, Putative low-molecular-weight cysteine-rich protein 9, Protein LCR9.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: RF1_LACP3
Sequence: MDKIFEQLDGLLDRYEELQELMSDPEVISDTKRYLALSKEEGGMRDVVAAYKKYKQVLSDIKESEEVLRESKDDDMEALAKEDLEDLQKQKADLEDQIKVLMLPKDPNDDKNIIMEIRGAAGGDEASLFAGDLLNMYMHYAERQGWKTEIIDATPTEVGGYKEVVVMITGDNVYSKLKYENGAHRVQRVPVTESAGRVHTSTATVGVMPEYDEVDLKIDPKDIRTDVYRSSGAGGQHVNKTSSAVRMTHIPSGIVVSMQDERSQQENRARAMQILRSRVYDYYETQNQEKYDQNRKNAIGTGDRSERIRTYNYPQNRVTDHRIGLTLNKLDRIMNGELDEIIDALIVHDQAQKMESLNV
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YLCH_ECOLI
Sequence: MRTYNPNSLLPSQMQKCTCNSLHLAFDLCGGEA
What are the official names of this protein?
Uncharacterized protein YlcH.
What is the protein family that this protein belongs to?
To equivalent protein in phage 82.
Protein: T2A_PARTE
Sequence: MKTVILALALIVLASSTQADVIATIKKIDQSPFGRTLFDTIYLELQTGDPLDRLLSTLTDLEDRYVAEQKEDDAKNQEYQGACTVDISAFDKDLAESNRKKIELEARLEGQLYPQRSILEGLVAQKKAEVKGYQKDLDELDAQRAEEHEDFEEKVLEHQEATAIIAEARRLFADNIEHGSFIQKGKATKQTHKFTKEVASMIQKHFTTSAKKTAKFQHRKGYSKLFKAFATIASKVEQLADAGAVQKIIDLADELLAKIADSLSLLRFAEDKRVEAYKKSRNFIVISLNVAGSALANATSDLASLNDIIAQVEASLDTTEQRIENVSADRHDRFTQCEEAVQDYQDARAARTSDRDVVSQTIGLVNKELRTLREQLALRQQAGEEI
What is the function of this protein?
Structural protein that crystallize inside the trichocyst matrix.
What are the official names of this protein?
Trichocyst matrix protein T2-A, Secretory granule protein T2-A, TMP 2-A.
What is the protein family that this protein belongs to?
Belongs to the TMP family.
What are the subcellular locations of this protein?
Trichocyst. Note=These are architecturally complex secretory storage granules-docked at the plasma membrane, ready to rapidly respond to an exocytotic stimulus.
Protein: AMPA_BACMK
Sequence: MFRVQKELVSHEAVIVALFEEDKKSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTNVKRYYFVGLGKKESYTTETLRAALGKAFKALQAAKVQDAAILLDSFVTDKLDAIDVAHIAAEVQGLGTYELQTYKADKKDRVELEKFTAITAEDAQEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSTEPPKMIALIYKGKEEWKDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLVDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEASMETDEPIWQLPIFERDKERVKNSKFADLNNSPGREGHAVMAGTFIGEFAEETPWVHLDIAGTSETSGAHDLGPSGATGAMVRTLATLVERFGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNDA_ECOLI
Sequence: MLLLIPSNHISIKETSSLMVVTPSSRTLFVVIVSFQQRALTSSVPVFLAVKRGR
What are the official names of this protein?
Protein GndA.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ARGJ_DESVH
Sequence: MSASPKGFRFATVSAGFRKEARPDLALIVSDTPATAAGVFTTNRFQAAPVVVARENLSARPVARAVVINSGQANACTGDEGMTNCRTTLDLVGKACGIPAAEVLPASTGVIGAQLHMDKWREAAPRLAAALGQNTHHDFARAIMTTDAFPKVAERELAIAGTTVRLVGMAKGAGMICPNMATMLSVVLCDAAVTPEAWQRLFLDAVDRTFNRVTVDGDTSTNDTVFGLANGASGVTVEGEDLAKLGEALTDVLARLAYMLVQDGEGATKVMRVKVSGAVDDAEAEAVARTVGHSQLVKTAMYGRDANWGRIVAAVGRSGASFKAEDVVVTLCGVELFRNGQPTDLDFDTLLREPLKGRDVTVDIELGAGTGHYELLASDLTHDYVNCNADYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIAA_SALAR
Sequence: MLTLDTLNVMLAVSEEGMVEEMILALLASPQLVIFFEKFPRLKNAVTADLPRWREALRSRLKDARVPQKLTEEVMCYQQSQLLSTPQFIVQLPQILALLHRLHSPYAAQAKQLVESNSTFTPSLHTLFLQRWRLSLVVQATTLNQQLLEEEREQLLSDVQERMTLSGQLEPTLAENDNAAGRLWDMSAGQLKRGDYQLIVKYGEFLAAQPELKQLAEQLGRSREAKSVPKKDAPMETFRTLVREPATVPEQVDGIQQSDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLHGEAWREKVTERPVVHQDVDKQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRVALADNRRCFIMLFSTEVVRYELSGPEGIEQAIRFLSQRFRGGTDIASCFRAIIERMQRRKWFDADAVVISDFIAQRLPDDVVSKVGELQRLHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLLRRWRR
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.
Protein: RL15_MAGSA
Sequence: MKLNELRDNEGARYQSKRLGRGIGSGKGKTSGKGVKGQTSRTGVAINGFEGGQMPIYRRLPKRGFHNPNAKHFAVINLGRLQKAIDEKRIDAKATITAEILSAAGLIGKVLDGVRLLGHGEIKAKVSIEVTGASAAAIAAVEKAGGSVTVAAPKAVAEG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: VP11_CTFVL
Sequence: MPALAIIGDTLLNASLIDKYTPPSSNAQNQGFTTYVHSVKPLIPQIIGIPEDALKQWTLFTDWAKLNDIDLNADETFKEILTIGKRLVSGDITQFVYRQFRGKLEVGYFGKTDNVREKPSFFPLLGAGQIESLKDLLSRHFEVWVYFAPKPVIDWMIRHEIDLATVEFDVRNMLKMLSNNPIKWETLLEKIANVAESRITADRDEVGEWRPWVIGLLMIFGQSLKIGGLMAVLKWRQLGPVCYRNLSRV
What are the official names of this protein?
Uncharacterized protein VP11.
Protein: RPB9_CANGA
Sequence: MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYIEEAGSPLVYRHELITNIGETAGVVQDIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLACSHIFTSDQKNKRTQFS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template.  Involved in the regulation of transcription elongation (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB9, RNA polymerase II subunit B9, DNA-directed RNA polymerase II subunit 9.
What is the protein family that this protein belongs to?
Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CYS1_MOUSE
Sequence: MGSGSSRSGRIPRRRRSPDRRQTGPGETASEGGTADQAPTAAGQEESGRDPRPATPSGGREETLRLLDQLLAESEAWGPQELTPRGPARLAPAVSPEKKVKGNPEDSCASEAPGNSPKRPEGQSAISYDYSEEELMASIEREYCR
What are the official names of this protein?
Cystin-1, Cilia-associated protein.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Lipid-anchor. Cytoplasm, cytoskeleton, cilium axoneme. Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus (By similarity). Expression is enriched in the ciliary axoneme.
Protein: LYS4_CANPA
Sequence: MRLHLHRFISTSTPLRSGQNLTEKIVQKYAVNLPPNKLVHTGDYVTIKPAHCMSHDNSWPVATKFMGLGAKRVKDNRQIVCTLDHDVQNKTEKNLAKYANIERFAKEQGIDFYPAGRGIGHQIMIEEGYAFPLNLTVASDSHSNTYGGVGSLGTPIVRTDAASIWATVQTWWQIPPVAKVELKGNLQNGVTGKDIIVALCGVFNNDEVLNHAIEFVGDGVENLPIDYRLTIANMTTEWGALSGLFPIDDKLIEFYEGRLQKLGPNHPRINKDTIEALRRGSLASDEDAKYAKHLVIDLNTLSPYVSGPNSVKVSNPLSKLSQDNIAINKAYLVSCTNSRLSDIQAAADVLKGHKVHPNVEFYVAAASSLVQQDAEAAGAWQTIIDAGAKPLPAGCGPCIGLGTGLLKDGEVGISATNRNFKGRMGSKDALAYLASPEVVAASAVLGKIGAPEEIDGKPVNASPEIVKSIDLPKSSGNTGATSEEPISEDDTSEASVEVLPGFPKSIQGELILCNADNINTDGIYPGKYTYQDDISREQMAEVCMENYDPEFKTKTKSDDIIISGYNFGTGSSREQAATCILARGMKLVVAGSFGNIFSRNSINNALLTLEIPELIEKLRVKYDGVNELTIRTGWFLKWDVTKALVTVADLDGEVILQQKVGELGTNLQDIIVKGGLEGWVKSELQKEQ
What is the function of this protein?
Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
What are the official names of this protein?
Homoaconitase, mitochondrial, Homoaconitate hydratase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RK24_ARATH
Sequence: MATMSALQSSFTSLSLSPSSSFLGQRLISPISLSVTSPVKPAENPCLVLAKLKRWERKECKPNSLPILHKMHVKFGDTVKVISGRDKGKIGEVTKIFTHNSTIVIKDVNLKTKHMKSREEGEPGQIVKIEAPIHSSNVMLYSKEKDVVSRVGHKVLEDGQKVRYLIKTGELIDTIEKWKLLKEAKDKETTQVAVTSAS
What is the function of this protein?
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity).  Required for optimal plastid performance in terms of photosynthesis and growth.  Required for the translation of plastid mRNAs.  Plays a critical role in biosynthesis of thylakoid membrane proteins encoded by chloroplast genes (PubMed:22900828).
What are the official names of this protein?
50S ribosomal protein L24, chloroplastic, CL24, Protein SUPPRESSOR OF VARIEGATION 8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YCHJ_ECODH
Sequence: MSQLCPCGSAVEYSLCCHPYVSGEKVAPDPEHLMRSRYCAFVMQDADYLIKTWHPSCGAAALRAELMAGFAHTEWLGLTVFEHCWQDADNIGFVSFVARFTEGGKTGAIIERSRFLKENGQWYYIDGTRPQFGRNDPCPCGSGKKFKKCCGQ
What are the official names of this protein?
UPF0225 protein YchJ.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.
Protein: RUVB_STRCO
Sequence: MNWDDTTDAEAAAERLVGAAADGEDQAVEAALRPKDLGEFIGQEKVREQLDLVLRAARARGATADHVLLSGAPGLGKTTLSMIIAAEMEAPIRITSGPAIQHAGDLAAILSSLQEGEVLFLDEIHRMSRPAEEMLYMAMEDFRVDVIVGKGPGATAIPLELPPFTLVGATTRAGLLPPPLRDRFGFTAHMEFYGPAELERVIHRSAGLLDVEIDPTGAAEIAGRSRGTPRIANRLLRRVRDYAQVKADGLITQEIAAAALAVYEVDARGLDRLDRGVLEALLKLFGGGPVGLSTLAVAVGEERETVEEVAEPFLVREGLLARTPRGRVATPAAWAHLGLTPPRPQSSGNGQPDLFGA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LAN11_PROMM
Sequence: MSEEQLKAFIAKVQADTSLQEQLKAEGADVVAIAKAAGFSITTEDLEKEHRQTLSDDDLEGVAGGFFCVQGTANRFTINVC
What is the function of this protein?
Lanthionine-containing peptide (lantipeptide) with unknown function (Probable).  Does not show antibiotic activity against Lactococcus lactis 117 and Bacillus subtilis 6633 bacteria (PubMed:20479271).  Organisms that produce this peptide live in oligotrophic environments at very dilute concentrations, suggesting this peptide is not secreted to influence other bacteria (Probable).
What are the official names of this protein?
Lantipeptide prochlorosin 1.1, Lantipeptide Pcn1.1.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAA_SHEB8
Sequence: MAVSLWQQCIGRLQDELSAQQFSMWIRPLQAEMDGDTLVLYAPNRFVLDWVRDKYINIINQFFTEQMGSDAPKLRFDIGSRPSAKKPSVPAPIAPTRVANTQTKATVGTTFNVQAEPMANANHRSNINPSYQFDNFVEGKSNQLGKAAALQVAENPGGAYNPLFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRSQEEFFHTFNALLEGNHQIILTSDRYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPRQVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLN1B_RHOCA
Sequence: MSAVKKALDLMKAEEVEYVDIRFCDPRGKLQHVTLIADLVDEDFFEEGFMFDGSSIAGWKSIDQSDMKLIPDASSVYIDPFYAEKTMCVHCNVVEPDTAEAYSRDPRIALKAEAYLKASGIGDVAYFGPEAEFFIFDDVRYSVTPAKVAYQIDAEAAAWNTDAEVEMGNLAHRAGHKGGYFPVNPVDEAQDLRGEMLSTMKRMGMKVDKHHHEVATCQHELGLIFGGLTEQADNILKYKYVIHNVAHAYGKTVTFMPKPMKGDNGSGMHVNMSIWKDGKPLFAGDKYADLSQEALYFIGGILKHAKALNALTNPGTNSYKRLIPGFEAPVLRAYSARNRSGCVRIPWTESPKAKRVEARFPDPSANPYLAFAALLMAGLDGIKNKIDPGPASDKDLYDLPPEELAAIPTVCGSLREALTELEKDHDFLLAGDVFTKDQ
What is the function of this protein?
Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I beta, GSI beta.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLRX2_RICCN
Sequence: MLENKNFKFIENEIKNNKVVLFMKGIKKSPACGFSGTVVAILNKLGVEFRDINVLFDAELREDLKKFSDWPTFPQLYINGELVGGCDIARELYQSGELEKMLKAYTR
What are the official names of this protein?
Probable monothiol glutaredoxin 2.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. Monothiol subfamily.
Protein: RL11_ACIET
Sequence: MAKKIVGFIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAQTQGVEPGLPLPVVITAFADKSFTFVIKTPPATVLIKKAIKLDKGSSNALSTKVGKITRAQLEEIAKTKLKDMNAASVDAAVRTLAGSARSMGVTVEGL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.