PharMolix/UniProtQA huggingface dataset:
Protein: NUON_FRATF
Sequence: MIMSLSILYILPEILLALGVIVVMFSGLFLHGKIRNINYIFFQVFTLLALIATFAKEYLIQTTGLVFEGQVVFSGFAYTLQLVILVLAVFVALYSRDYVKDRKISDGDFYTLLMLCVLGAMVLTAAHSLVTIYVGLELLSLPMYALIAIYRDSGKGLEAAIKYFVLGAIASALLLFGMSFVYGMTGKLDITEIANVLAHGNFAGLQQQFLLVYLVMMIATFLFKLGAFPFHMWLPDVYQGAPNAVANIVATIPKVAAFAMLVNILFVGFPSLKDSWIYLFRIIGILSIFFGSLVALSQTNVKRLLGYSTVSQIGFVLLATTLNPQGYALTAASFYVIVYLFTTLAVFGVLTTISVGGYEVQDLNDLKGFNTKDSWLAFILLIVLFSMAGIPPFGGFIAKLFVVMGLINDGNYFLACFVLFMAVIASFYYVRVIKTMYFDDPDNDETVKPPLTSLIALSINGLVLLFLGIMPMLLLGVLTQVTNVI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRMFO_SULSY
Sequence: MKVAVIGAGLAGSEAAYKIAQAGYKVDLYEMRPEKQTPAHKTPYFAEIVCSNSFGSESLTSGAGLLKKEMEVLGSIILDVAKEFKVPAGQAFAVDREKFSKKLTEILENHPNINVIRQEVKTLPDADIIVIATGPLTSEEFSKEIQKITGSEYLYFYDAIAPVVDASTVDFSKGFWADRYGKGTGDYFNCVLSEQEYEIFYQELLKGEQVPLKDFERAVYFEGCLPIEEIARRGKETLLYGPMKPVGLIDPKTGKRPYAVVQLRKENIEGTLLSLVGFQTKLKYPEQKRIFSLIPALKDAEFVKLGSIHRNTFIQSQKLLKPTLQLRKKPNILFAGQITGVEGYMASAATGIIAGINVARMLEGKEPVVPPKTTMIGGLINYITTAKNELQPMGPNYALLPELEEKIKGKEERKLKKAEIALKDIKEWTKEIESAVFI
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOV_DROME
Sequence: MLKDAHQKLIKHRQSTKLSMTDFACQAAPVKQPLPLELPLPLSVQLQLLAKTPTSDHAPMHSTPPTTPPTPPPLPLNMSQSASAVTEAATPENSLPATPPSEGALAVPSAPQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFGMLDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGLRRKREQESDRDLESDQELGGSSPMPRRKQARPRRRSGDVPHDFTLNKTDAESLQTVIKHELLERAERDQEEAPDQDNSQGEAEKISSSPAKTLVERAKEQKSMKEEGSDQPRSLNENHHQLELDDEDDDDQDHEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNPSPCLSDGPEDLCTTKKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGNNGLLTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGSGEHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNLLGPMGMPPFGGHNGGHPGNSGPGNGCPGQAAHERLEESMNRLSKELGKEFGKEFGKEFGKEFGPASPMSLQGPFNAPDGPPHPPSPLPFPGMSSAMTLTPPHMFGLDSPLGLFPPGIDPGKLYNPLMEMSDPRDMPGGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGPPIEMLQMGIGGGSGGSTKNEKSKERKEKEKDKNSMSSNGSGGSANSQGGAPTSGSGPMQHSGELGPMGQLDLDLGLPLGPPGGPRSNSSEPDLLSAPNALFNPFNPQGFYPDFSGGFPGLPLSMLNLLPPAERHHAAAAMHHLGVSMDEDCKSVGSKQSSSVDEDYSGPGIPLSLEHRREISATGPPLTPSNGGTGHD
What is the function of this protein?
Has a regulatory role during midline cell development.
What are the official names of this protein?
Protein jim lovell, Protein TKR, Tyrosine kinase-related, dTKR.
What are the subcellular locations of this protein?
Nucleus.
Protein: FMO4_MOUSE
Sequence: MAKKVAVIGAGVSGLSSIKCCLDENLEPTCFERTSDFGGLWKFADTSEDGMTRVYRSLVTNVCKEMSCYSDFPFREDYPNFMSHEKFWDYLREFAEHFGLLRYIRFKTTVLSVTKRPDFSETGQWDVVTETEGKRDRAVFDAVMVCTGQFLSPHLPLESFPGIHKFKGQILHSQEYRIPDAFRGKRILVVGLGNTGGDIAVELSEIAAQVFLSTRTGTWVLSRSSPGGYPFNMIQTRWLNFLVRVLPSRFINWTHERKMNKILNHENYGLSIAKGKKPKFIVNDELPTCILCGKVTMKTSVKDFTESSVIFEDGTTEANIDVVIFTTGYEFSFPFFEEPLKSLCTKKIILYKRVFPPNLERATLAIIGLISLNGSILVGTEFQARWATRVFKGLCSIPPSQKLMAEATKTEQLIKRGVIKDTSQDKLDFITYMDELTQCIGAKPSIPLLFIKDPRLAWEVFFGPCTPYQYRLVGPGRWDGARNAILTQWDRTLKPLKTRIVPKSPEPTSLSHYLIAWGAPVLLVSLLLIYKSSHFLELVQGKLPRRFPPYRLLWYMPQNS
What is the function of this protein?
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
What are the official names of this protein?
Dimethylaniline monooxygenase [N-oxide-forming] 4, Dimethylaniline oxidase 4, Hepatic flavin-containing monooxygenase 4, FMO 4.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RS10_MYCS5
Sequence: MAKTQIKVFGFDHKVVDEAAKKLVSLAVATKNKFVGPIPMPTKREEVTILRSVHVNKKSREQFESRTHQRLVVLENPSSELLDKLKRLELPAGVGLKFKEK
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: FAU1_THEKO
Sequence: MSTDTRPTVRIRGIYSTALTKLFLDRGFGISQPSNKIVERFGLEKTYDDFDVDIYDKKDRHGVVLVGDAVEEAKKVLEEELIDVFFRRLPYQLYGIYKGLVVKIDEKYVYVDLGSAIGTIPRKDLPKAVEGDEILVQVKKHNLLPHLSTTLTIPGDYAVLIPKPIGAQRHVKISRKIRDNQERERLRILGLSIDLGKWGVLWRTAAAYKDWNLLRDEIVRLSKLADRLAKADTYFAPSLIIEGRNIYEVEFGGGAKRKLDEIRNKVVPTVDGHHQLKAKDPELGFAVEIAEGILSKVPGQRVKVNQGFWEALVENKGPKKGWLFTLEHVKPDGQRIRLGPGEVLEVSHNPLRVTIKRHLKPGKFYDGLELPIEFGDYAITELEAGKWWFVHRYYDKNGNLKGEYYNINTPVEIYPDGARYVDLEVDIVKWPDGKKEIIDQEELKEHYEEGIISEKLYRAVLRITQEVFERV
What is the function of this protein?
Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs.  Preferentially cleaves UA sequences in the 5' precursor region of 5S rRNA (PubMed:28978920).  Binds to RNA in loop regions with AU-rich sequences (By similarity).
What are the official names of this protein?
Probable ribonuclease FAU-1, RNA-binding protein FAU-1.
What is the protein family that this protein belongs to?
Belongs to the FAU-1 family.
Protein: GAST_FELCA
Sequence: MQRLCVCVLILALALTAFSEASWKPRSQLQDAPSGPGANGGLEPHWLNRLGPASHHRWQLGLQGPPQQVADLSKKQGPWLEEEEAAYGWMDFGRRSAEDGDQHP
What is the function of this protein?
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes.  It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
What are the official names of this protein?
Gastrin.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MEND_ECO24
Sequence: MSVSAFNRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPTHSISLPRPTQDIPACWLVSTIDHALGTLHAGGVHINCPFAEPLYGEMDDTGLSWQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEPEEYWIVDDIEGRLDPAHHRGRRLIANIADWLELHPAEKRQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRISDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNGGQIFSLLPTPQSERERFYLMPQNVHFEHAAAMFELKYHRPQNWQELETAFADAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: RS4_BOMMO
Sequence: MARGPKKHLKRLNAPKAWMLDKLGGVYAPRPSTGPHKLRECLPLVIFLRNRLKYALTGNEVLKIVKQRLIKVDGKVRTDPTYPAGFMDVVSIEKTNELFRLIYDVKGRFTIHRITPEEAKYKLCKVKRVATGPKNVPYLVTHDGRTIRYPDPLIKVNDSIQLDIATTKIMDFIKFESGNLCMITGGRNLGRVGTIVSRERHPGSFDIVHIKDSTGHTFATRLNNVFIIGKGTKAYISLPRGKGIRLTIAEERDKRIAAKVAAQ
What are the official names of this protein?
40S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: YBEY_MYCA1
Sequence: MSIEVSNESGIDVSEAELISVARFVIAKMDVNPAAELSMVLLDTAAMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPAMLGDIVLCPEFAADQAAAAGHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFALQDRLLEEWVADQVEAYHQDRQQERDRRLLDKSRYFDN
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STC_CLOBE
Sequence: MLRRYTYNEIIKKSHKRCSNYGIKIDIPCPSKILRDEEFNVIIQKNKALIEIARPFMEILYNFLKGSGFSLYFTEKNGVVLTIIGDQDIIRDQIQMGIIEGADMSEKSAGTNGIGTAFAENISLQISGEEHFIKVFQIWTCSSSVVHDEDGNIIGCLNLTGRRQLAHPHTLGLVVAAVKSIENHLKVKKTQNELVKTYQYLNKITDSVNLGIFAVDTKGIIKAINKSACDMLHINEEDVINKNVDTVLDSWKHILQRLRNGQSYEDEEIMYSDKKKRFNINVYPIKDKNSNITGMVGIFKDIQNVYNLVNKYINRTAKYTFDDIIGQSEAMKRLKEQIKSISNSPSTVLIQGESGTGKELIAQSIHNNSNRRSKSFVAINCGAIPKSLIESELFGYEEGAFTGAKRGGCPGKFELANEGTLFLDEIGEMPLDMQVNLLRVLQEGCITRIGGNKCVDVDVRIIAATNKNLKKEIEDGNFREDLYYRLSVIPIYVPPLRERNGDIGILIEHFLKIKADKLGKLIPEIRKNIYENLLSYGWPGNVRELENCIENIVNMNGNTSFNFENRTIKKDVNCYSDVSLEYDMCSLEELEKRAISICINQCGGNISKACRILGINRSTLYIKIKKYNIKVR
What are the official names of this protein?
Signal-transduction and transcriptional-control protein.
Protein: NDHH_OLIPU
Sequence: MKRPVTGKDLMIVNMGPHHPSMHGVLRLIVTLDGEDVVDCEPILGYLHRGMEKIAENRAIIQYLPYVTRWDYLATMFTEAITVNGPEQLGNIQVPKRASYIRVIMLELSRIASHLLWLGPFMADIGAQTPFFYIFREREFVYDLFEAATGMRMMHNFFRIGGIAADLPYGWIDKCLDFCDYFLTEVVEYQKLITRNPIFLERVEGVGIIGGEEAINWGLSGPMLRASGIPWDLRKVDRYESYDEFEWDIQWQKQGDSLARYLVRLNEMTESIKIIQQALEGLPGGPYENLESRGFDRKRNPEWNDFEYRFISKKPSPTFELSKQELYVRVEAPKGELGIFLIGDQSGFPWRWKIRPPGFINLQILPELVKRMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RLME_JANMA
Sequence: MAKNKLNKNWLHDHINDPYVKLAQKEGYRARAVYKLKEIDETEKLIKPGQIIVDLGATPGSWSQYVRNKLSGSVGGGINGTIIGLDMLPMEPIADVHFIQGDFREQEVLEQLEQVLQGRKVDLVISDMAPNLSGIAVADAARMIDLIDLAIDFTQHHMKPSGSLLVKCFNGSGYSYIVEKFRDEFKTVVQKKPKASRDKSSEIFLLGKTLKNPL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGL3_WHEAT
Sequence: RASPPSESRAPLRAPQRSATRQHQARQGPRRMCNGGRGPPYWTAGVTSAPARQTPLFSGRPSGGLSDPNEVAAVILGGGTGTQLFPLTSTRATPAVPIGGCYRLIDIPMSNCFNSGINKIFVMTQFNSASLNRHIHRTYLGGGINFTDGSVEVLAATQMPGEAAGWFRGTADAWRKIIWVLEDYYKNKSIEHILILSGDQLYRMDYMELVQKHVDDNADITLSCAPVGESRASEYGLVKFDSSGRVVQFSEQPKGDDLEAMKVDTSFLNFAIDDPAKYPYIASMGVYVFKRDVLLNLLKSRYAELHDFGSEILPRALHDHNVQAYVFTDYWEDIGTIRSFFDANRALCEQPPKFEFYDPKTPFFTSPRYLPPTKSDKCRIKEAIILHGCFLRECKIEHTAFSRLNSGSELKNAMMMGADSYETEDEMSRLMSEGKVPIGVGENTKISNCIIDMNARIGRDVVISNKEGVQEADRPEEGYYIRSGIVVIQKNATIKDGTVV
What is the function of this protein?
This protein plays a role in synthesis of starch.  It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase large subunit, chloroplastic/amyloplastic, ADP-glucose pyrophosphorylase, ADP-glucose synthase, AGPase S, Alpha-D-glucose-1-phosphate adenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast. Note=Found in the chloroplast in leaf. Found in the plastid in the developing endosperm.
Protein: H2BL3_STRPU
Sequence: MPAKAQAAGKKGSKKAKAPKPSGDKKRRRKRKESYGIYIYKVLKQVHPDTGISSRAMSIMNSFVNDVFERIAAEASRLAHYNKKSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTTSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Late histone H2B.L3.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PRIO_ATEGE
Sequence: MLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHNQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYNNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLI
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: URED_STRT1
Sequence: MTQVYDGFVHLGFSNRNGRTISHKKYQEGNSRVSADNSDANGVPYYFLINMGGGFVEGEQYQVTIDVNKDAHALVTTQTPTYVYKCEKGQLTQQNTSITLEENSYLEYMADEVIPYLKSRYFQTSRIDMDKSAHLIYSDGVTAGWSHEDLPFQYHYFRNLTQIYQDNELVYSDQTLLEPEKQDMFKLGYFEGWRNYNSLVMVSPNIDETFVKALQKHLEGLNLESDFAISSLDISGLVLRILGRTAEDNRRIIYSCADYFRQEIHGLTPLNLRKNDMRR
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAT_HV2BE
Sequence: METPLKAPESSLKPYNEPSSCTSERDVTAQELAKQGEELLAQLHRPLEPCTNKCYCKRCSFHCQLCFSKKGLGISYERKGRRRRTPRKTKTPSPSAPDKSISTRTGDSQPTKEQKKTSEATVVTTCGLGQ
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors.  Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.  Through (By similarity).
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus.
Protein: ATP9_PEA
Sequence: MLEGAKSIGAGAATIASAGAAVGIGNVFSSLIHSVARNPSLAKQLFGYAILGFALTEAIALFALMMAFLILFVF
What is the function of this protein?
This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.
What are the official names of this protein?
ATP synthase subunit 9, mitochondrial, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: RS5_HYDS0
Sequence: MGAKDLNQRIDAKRIEQGITTLDDIQFEERLLEAARTTRVTKGGKRFSFSALVVIGDKRGYVGFGLGKAREVPLSIAKAIEDAKKKTIRVPIVNGTIPHDVVGEYGSARIIAFPARRGTGVIAGGAAKPIFELAGYTDVLTKVVGSSNHHNVVRAVFDALLKLRDIDAIAKVKGATVEDLRERYNIYAR
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: Y2825_VIBC3
Sequence: MPITSKYSDEHVESILTEIAAVLNKHNASPELTLMVVGNIATNVINQNVAAAQRKVIAEKFAQALVSSLQS
What are the official names of this protein?
UPF0352 protein VC0395_A1625/VC395_2155.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: STN1_DANRE
Sequence: MAVSLGDDDADELPSMLWGLDPVFSSYCRLYITDILLMKESRQVPGIYFYKTHPIFQVDVLGIVVYKREREDFYCYGVDDSTGVINCLCWKDEKWRDQGGSTTCGDASGFPRSFNIEDELKGLKEAERKSTVLEIGDLLRVRGTVKTSRDNREIKATSFYKVHDPAMAVQISRMLELPQLYRKCYDQPFKMPSDDLGSTEAGGSSHPQYLLSRAVLTLKEFLLEKEVTRFRPYDVEFLLHPLIQRSSAEQEADQPGTSFATQVGKLLKETLSFLQDEGQIFRKKRTQDEVYNVTEQDKDLHIAIKDVLREDTKREKYAEKGCHVLHILSSVRQRYSQNLSREVLEVALTFLESNSDIISTTEAHYIVL
What is the function of this protein?
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex.  The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves.  Initially the CST complex has been proposed to protect telomeres from DNA degradation.  However, the CST complex has been shown to be involved in several aspects of telomere replication.
What are the official names of this protein?
CST complex subunit STN1, Oligonucleotide/oligosaccharide-binding fold-containing protein 1, Suppressor of cdc thirteen homolog.
What is the protein family that this protein belongs to?
Belongs to the CTC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RS27A_HUMAN
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPEDK
What is the function of this protein?
Component of the 40S subunit of the ribosome (PubMed:9582194).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
What are the official names of this protein?
Ubiquitin-40S ribosomal protein S27a, Ubiquitin carboxyl extension protein 80.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
Protein: AROK_BRUSI
Sequence: MSGTNKQTNLHRQTETIRQLLGSKVVVLVGLMGAGKSTIGRKVANMLNLPFKDADTEIETVSRMTVAELFEAYGEVEFRDLERRVILRLLDDGPMVLATGGGAYMNAETRAAIAEAGISIWINADLDVLMERVSRRQNRPLLRNSDPRGVMQRLMDERYPVYALAELHLMTRDEKKEVIAAELIEVLAAHLEKEQAASAG
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF157_IIV6
Sequence: MEIDKVFCDTIMYQDLEILQDYLDTFKLDPQLTLILKKYKHASPFWKSDEKSFWIFEGILHDEAERVKQLNGVKTRNKVGFIYIKQIFYDIVELLLEATNDKKASSIDSRCVVCYENEICIKIQPCNHFVVCKSCFNRLNTCPMCRSKINKS
What are the official names of this protein?
Putative RING finger protein 157L.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 157L family.
Protein: H2AJ_MACFA
Sequence: MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESQKAKSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.J, H2a/j.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RSMC_PECAS
Sequence: MSALTPASEVILRHSDEFLSRRVLFAGDLQDTLPAQFEAASVRVHCNQYHHWQQMAKPLGDNAQYSLVADAELVADSDTLIYYWPKSKQEAEFQLCNLLSLLPVGAEIFVVGENRSGVRSAETVLSDFVELVKIDSARRCGLYHGRIDKQASFTLDDWWDEYVTEGVTVKTLPGIFSRDGLDPGSRLLLSTFEPHMKGKVLDIACGAGVLASVLAKQSPKIRLTLSDVSAAAVESSNATLAANALEGSVIASNVYSDIDGRFDMIVSNPPFHDGLQTSLQAVEMLIRGAVTHLPIGGQLRIVANAFLPYPALLDAAFGSHEVLAQTGRFKVYQATVGRPPRTGKGRRR
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC6O_HALMA
Sequence: MRRFERKQNIFRNKDALGESYQPERIEERDEEIEEYMNALQPVIDGWEPNNIFLYGNTGVGKTAVTDYLLDRLQDDVAAYDDIDLSIISLNCKTLNSSYQVAVELVNELRPSGGEISTTGYPQQTVFKKLYQELEAIGGTILIVLDEVDSIGDRDELLYELPRARANGNLDSAKVGVIGISNDFKFRDQLDPRVQDTLCERELQFPPYDATELKNILESRVEVAVTDGSTDTGVLQLCAALAARDSGSARQALDLLRLGGEIAENREAEMIKEGHIEDARSQLEQERVEEGMRELTTHGRLALLAVISKAAKEETPCRTRDLYEEYRSLCESSETDALGQRSLHNHLSDLRMLGILSAHENRSGSRGNYYNYELDVPFTSAIEAMSDVLHLTTEIDTIRDIAAMNNVG
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 15.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.