PharMolix/UniProtQA huggingface dataset:
Protein: S38A9_XENLA
Sequence: MDSDQTPLINPSLFEECAQNHFAAADSRSRRPFHIEPSYITSINDDEPQRITSEASAMNKRIHYYSKLSYPSGGGLIAPDHVLPAPEEIYVYSPLGTALKIDGSDGSEKNSSIVTIFMIWNTMMGTSILSIPWGIKQAGFTTGVCVLFLMGILTLYCCYRVVKSRGTIPLTDTSTWEFPDVCQYYFGSFGRWSSLLFSMVSLIGAMIVYWVLMSNFLFNTGKFIYNYVNDVNITDDVLSNNGTDKVICPNPDSTGPLNKSMDTYYGNGTNLEHFETWWSKTNTVPFYLVVLLLPLLGFRSPSFFAKFNILGTVSIIYLVSLVTLKAAHLGFHLQFSWNQVQTFFVPEFRVSFPQLTGILTLAFFIHNCIITLLKNNRNQKNNVRDLSIAYLLVGLTYVYVGVVVFASFPSPPLSKQCIEQNFLDNFPSSDILAFVARIFLLFQMMTVYPLLGYLVRVQLLGHIFGDIYPSIFHVLALNIAVVGVGVIMARFYPNIGGIIRFSGAACGLAFVFVYPSLIHMISLHRRGQLRIHSILIHVSIIVLGISNLIAQFFM
What is the function of this protein?
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels.  Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids.  Acts as an arginine sensor.  Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation.  However, the transport mechanism is not well defined and the role of sodium is not clear.  Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency.
What are the official names of this protein?
Neutral amino acid transporter 9, Solute carrier family 38 member 9.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Protein: HBBF_BOVIN
Sequence: MLSAEEKAAVTSLFAKVKVDEVGGEALGRLLVVYPWTQRFFESFGDLSSADAILGNPKVKAHGKKVLDSFCEGLKQLDDLKGAFASLSELHCDKLHVDPENFRLLGNVLVVVLARRFGSEFSPELQASFQKVVTGVANALAHRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin fetal subunit beta, Beta-globin, fetal, Hemoglobin beta chain, fetal, Hemoglobin gamma chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: IHFA_MARN8
Sequence: MAALTKADMAERLYEELGLNKREAKEMVEAFFDEIRGALSHNEQVKLSGFGNFDLRDKKQRPGRNPKTGEEIPISARRVVTFRPGQKLKQKVEAYAGTQS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: AMPP2_ASPCL
Sequence: MRDMGRSDIVISAVDALDIHIAMTSNACDKYPAKQHARRVAVKLGVSTGLVYLAGQPTVNWGDSDQPRPFRQRRYFYYLSGVDEADCYVTYDIRNDLLTLYVPDFDLHRAVWMGPTLTVEEARERYDVDQVRYYASLQGDVQRWVDKYNQSSPLYILHDTQRPRVSSNEVRFDDESLLPAMDATRGVKDEHEIRMIREANRISGLAHRRVLENIHRMSNEAEIEGLFLNTCISHRAKNQAYELIAGSGENAAVLHYVKNNEPLRGRQLVCLDAGAEWNCYASDVTRTFPLGTDWPSAEARHIYQLVEEMQEECIKRIQKGVRFIDLQVLAHVIAIEGLMRLGILRGGSVEEIRESGASTVFFPHGLGHHVGLEVHDVSAKDLRASDADRDYYNSVLTPSTSHGPCTLSAPALEEGMVVTVEPGIYFSRLALANARKLPYAKYIDFNEAEKYIPIGGVRIEDDILVTSSGYENLTTAPKGEAMLEIIRRGIDN
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase ACLA_020440, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: TADA_AQUAE
Sequence: MGKEYFLKVALREAKRAFEKGEVPVGAIIVKEGEIISKAHNSVEELKDPTAHAEMLAIKEACRRLNTKYLEGCELYVTLEPCIMCSYALVLSRIEKVIFSALDKKHGGVVSVFNILDEPTLNHRVKWEYYPLEEASELLSEFFKKLRNNII
What is the function of this protein?
Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
What are the official names of this protein?
tRNA-specific adenosine deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: GLRB_RAT
Sequence: MKFSLAVSFFILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
What is the function of this protein?
Glycine receptors are ligand-gated chloride channels.  GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels.  Channel opening is triggered by extracellular glycine (PubMed:15574743, PubMed:14551753).  Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1.  Plays an important role in the down-regulation of neuronal excitability.  Contributes to the generation of inhibitory postsynaptic currents (By similarity).
What are the official names of this protein?
Glycine receptor subunit beta, Glycine receptor 58 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Synapse. Perikaryon. Cell projection, dendrite. Cytoplasm. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane. Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane.
Protein: IF1_XANC5
Sequence: MSKDDSIEFEGSVSETLPNTTFRVKLENGHEIIAHISGRMRKNYIRILTGDRVKVEMTPYDLTKGRITYRMK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSE_ECOL6
Sequence: MLIFEGKEIETDTEGYLKESSQWSEPLAVVIAENEGIALSPEHWEVVRFVRDFYLEFNTSPAIRMLVKAMANKFGEEKGNSRYLYRLFPKGPAKQATKIAGLPKPVKCI
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Could accept sulfur from TusD (By similarity).
What are the official names of this protein?
Sulfurtransferase TusE, tRNA 2-thiouridine synthesizing protein E.
What is the protein family that this protein belongs to?
Belongs to the DsrC/TusE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGC_BACSU
Sequence: MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSFSPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAGIILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL
What are the official names of this protein?
Uncharacterized protein YqgC.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PGK_STRP7
Sequence: MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEEADKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEAAINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQTGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_PSEAE
Sequence: MPDSALPPCSILLLAGGRGQRMGGRDKGLIEWQGLPLIAHLHRLVRPLTDDLIVSCNRNQERYAAYADRVVSDDSRDFPGPLAGIRAGLAVARHPWLLVLPCDAPRIDRALLETLLQAAGRTPARPWMLRCGGQWEPLFSLIPTHLAEEIEHAWRQGDRSPRHVLLPLGAEAIELAAGDPRLANLNTPELLANHRELK
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: API5_MOUSE
Sequence: MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQAFSPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLSTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRTSEDTSSGSPPKKSPGGPKRDARQIYNPPSGKYSSNLSNFNYERSLQGK
What is the function of this protein?
Antiapoptotic factor that may have a role in protein assembly.  Negatively regulates ACIN1.  By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation.  Also known to efficiently suppress E2F1-induced apoptosis (By similarity).
What are the official names of this protein?
Apoptosis inhibitor 5, API-5, AAC-11.
What is the protein family that this protein belongs to?
Belongs to the API5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear.
Protein: PG2IP_HUMAN
Sequence: MPSLWREILLESLLGCVSWSLYHDLGPMIYYFPLQTLELTGLEGFSIAFLSPIFLTITPFWKLVNKKWMLTLLRIITIGSIASFQAPNAKLRLMVLALGVSSSLIVQAVTWWSGSHLQRYLRIWGFILGQIVLVVLRIWYTSLNPIWSYQMSNKVILTLSAIATLDRIGTDGDCSKPEEKKTGEVATGMASRPNWLLAGAAFGSLVFLTHWVFGEVSLVSRWAVSGHPHPGPDPNPFGGAVLLCLASGLMLPSCLWFRGTGLIWWVTGTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPGGVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPKYFL
What is the function of this protein?
Involved in lipid remodeling during GPI-anchor maturation.
What are the official names of this protein?
PGAP2-interacting protein, Cell wall biogenesis protein 43 C-terminal homolog.
What is the protein family that this protein belongs to?
Belongs to the PGAP2IP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YL417_MIMIV
Sequence: MAMNSTLFLEIKNEYTEHLVDVLTPYIYEGLLAIYSRACEIADESKKSNKILSIFQKLLQSIDEWNQSRIDDETNRIKMTGQTQEYLDDLVKAVIRSNIILLSCNNNISQAICQNFYNGLSTSALIHRCYAECGKDAHNNPYLFFHGVEPLDYKRNQVIIQDHVRMGITRAIRKILPISMILKEYLVNSMNLFPDPNRTNPLFPAQSINNAINNPFQLPSPMQMPGQPTQIVQPVQAVQSMQQFQPFQIEQPMGSQMMGFGTNITAPETKNQIEQEIFNVIKSENVGQNPQKIKAIMNIEKIITSAEPNQIADFAAKTTSARDPMNLPQANPIGFQNNQFNQQKKLYQHPQHNQYNQIGSQGQNRDYRQNNSNHSNNSNHSNHVDRTDRTNQSTYTNQTNLTNQSNRSNYSNNKNYYNSKSRTGDYSEINKNSKQGHFEQSQNYSKDTESMFITPANGQNKLGTGGNIDLEKIDFNNINLIEDYGVKHSHE
What are the official names of this protein?
Uncharacterized protein L417.
What are the subcellular locations of this protein?
Virion.
Protein: APOC2_MIRAN
Sequence: MGIRYLLVLVLVLLVLGCEVQGAHMPQQDEATSPSLFTQMQESFYGYWGIAKSAAQGLYEKTYLTTVDEKIREIYNKSTAAVSTYAGIFTDQLLSMLKGDQ
What is the function of this protein?
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma.  Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.  Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
What are the official names of this protein?
Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RPPH_WOLPM
Sequence: MVEQKDKYRPCVGIMLFNRQGHAFIGKRFESDSYWQMPQGGVDDGEELEQAALRELLEEVGTNKVKVITKSKDWIYYNLPEEVIPICWNGKYSGQKQRWFLMKFCGEDEDIDINYTGHPEFKEWRWQGIDSLVASAISFKKEVYKTVIEEFSSIIKASTISS
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: NADA_HALMA
Sequence: METAAFETDLSLFKYDNLEQLPPSYRDLDADERTERIESALAELGDDVVILGHNYQRQEIVEHADFIGDSYQLSKEAAQSDADYVIFGGVTFMAESADIITDDDQSVILPSMEASCPMAGMAEALQVDAAWAELTAALDDEEIIPITYMNSYADLKAFCAEQGGLVCTSSNAHKAFEYAFEKGDKVLFLPDKHLGENTAHRLGMADETVEWDPWDAEGTDAADAVENDVILWEGYCQVHERFREHHIESIREDYPDANVIVHPECRREVVEAADVAGSTSTICESVAEADPGETWAIGTEIHLTHHLQRWHPDVNVVPLCGDACMDCNAMRQIDPNYLAWVLEELVEGRERNVIEVAPEEKELAQVAMDRMLEI
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_BUCAP
Sequence: MANIEKKNNSELQEKLITVNRVSKTVKGGRIFSFTALTVVGNGEGRVGFGYGKAREVPAAIQKAMEKARRNMVTIPLVNKTLQHSLKGSHTGSNIFMKPASDGTGIIAGGAMRAVLEVAGIHNVLAKTYGSTNPINVVRATMNGLTNMKSPEMIAAKRNKLIEDILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RAMA_ENTCL
Sequence: MTISAQVIDTIVEWIDDNLHQPLRIEDIARHAGYSKWHLQRLFLQYKGESLGRYIRERKLLLAARDLRESDERVYEICLRYGFESQQTFTRIFTRTFHQPPGAYRKENHSRTH
What is the function of this protein?
Probable transcriptional activator.
What are the official names of this protein?
Transcriptional activator RamA.
Protein: CLPS_BURO0
Sequence: MAIIPDKQDSTVLERKQQKLKPPSMYKVVLLNDDFTPMEFVVMVVQEYFKKDRETATQIMLKVHREGRGVCGVYTRDIASTKVEQVVTHARQAGHPLQCVMEEA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: DEOC_NOSS1
Sequence: MAAGYPNIDIAPFIDHALLTPTATPEQVDQWCEQADRYNFASVCLYPTYVKQAAEFLHGKKPKVCTVIGFPTGATTRSVKLYEALEAVENGATELDVVINLGCLKSGNTEAVHREIAEICEETGQVVKVILETNLLTDAEKKIAADIAMDAGATFLKTNTGWNGGATVADVKLLKDITRERVGIKASGGIRTLNQALDLILAGATRLGTSRGIDLIHQRDNPEKVE
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YB182_YEAST
Sequence: MKIFTLYTMIQQYFFDNGGVYSIKNFYSAVPKEKMNIILVSLDCELQKLALKLSKKTSGTHTTH
What are the official names of this protein?
Uncharacterized protein YBR182C-A.
Protein: UBC12_HUMAN
Sequence: MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK
What is the function of this protein?
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins.  The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4.  Involved in cell proliferation.
What are the official names of this protein?
NEDD8-conjugating enzyme Ubc12, NEDD8 carrier protein, Ubiquitin-conjugating enzyme E2 M.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Protein: SYD_STRS7
Sequence: MKRSMYAGHVRKEHIGRTIVLKGWVSRRRDLGGLIFIDLRDREGVMQLVINPEDVSGDVMATAERLRSEYVIEVEGSVEARQQANDKLATGAVELKVSGLTILNTAKTTPFEIKDGVEVSDDTRLRYRYLDLRRPEMLESFKLRAKTTHVIRNYLDNLGFIDVETPMLTKSTPEGARDYLVPSRISQGHFYALPQSPQITKQLLMNAGFDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLSEQEIQDIVEGMIAKVMKDTKGIEVKLPFPRMAYDDAMNHYGSDKPDTRFDMFLQDLTDLVKEIDFKVFSEAQAVKAIVVKGHADRYSRKDIDKLTEFAKQFGAKGLAWLKVADGAFTGPIAKFLTGVESKLTESLQLEHNDLVLFVADTLEVANNTLGALRTRIAKELDMIDMSQFNFLWVVDWPMFEWSEEEERYMSAHHPFTLPTAESAHELEGDLAKVRAVAYDIVLNGYELGGGSLRINQKDMQERMFRALGFTAEEANEQFGFLLEAMEYGFPPHGGLAIGLDRLVMLLAGKDNIREVIAFPKNNKASDPMTQAPSLVSEKQLEELQLQIEHHD
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGA_VIBFU
Sequence: MESKSHAHCFRAQRVLHGKQWQQDAVVTVDENGTISAIESYDGQRHADAIPLGPVDLMPGLIDSHVHGSQGCDVMDATHDSLNTMSRYFATLGVTAFVATTVTAPVAKIRAALAQVAKSKHDGVDGAEILGAYLEGPYFTEKNKGAHPTQWFRELAVEELEDWISYSDNQLLKVALAPEKTGALDAIRYLDAHGIHVMLGHSDADYEQVKAALAAGAKGIVHCYNGMRGLHHRDPGVVGAGLLHPHCFVEMIADGHHVHPAAIDVAHRCCGSRMTLITDAMRATGMPDGQYTLGEYQVDMKQGVVMTSSGGLAGSTLTLLRGVKNIHRWLNVPIEQAWLMASYTPAESLGIQHQLGSLEVGKYASMVAVSSDFSIEKTWVKGRLVFDAATSPRQEALCI
What is the function of this protein?
Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides.  Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate.
What are the official names of this protein?
N-acetylglucosamine-6-phosphate deacetylase, GlcNAc 6-P deacetylase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. NagA family.
Protein: HTDZ_MYCBO
Sequence: MRTFESVADLAAAAGEKVGQSDWVTITQEEVNLFADATGDHQWIHVDPERAAAGPFGTTIAHGFMTLALLPRLQHQMYTVKGVKLAINYGLNKVRFPAPVPVGSRVRATSSLVGVEDLGNGTVQATVSTTVEVEGSAKPACVAESIVRYVA
What is the function of this protein?
Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity.
What are the official names of this protein?
3-hydroxyacyl-thioester dehydratase Z, Enoyl-CoA hydratase 2.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: LST2_AEDAE
Sequence: MADDKSLLARFYHADRALTAVASELDSFDGRAEPVRCTRLVGRLRQGQDRVLAITNQIMDELLGDDRAPRAFRAKFPEEVLQESLAGQLWFGAECLAAGSSIMNREVESGVMRPLAKAVTKSLDNVRNLLREQCLRNNTPNSLTLRLDINDAATEQLYESLKIFDRLFAEFELLYVSAMVQVKSKQEYEMQELICVLFSETLQRALKIGLLEQEQVDSYDPALMFSIPRLAIVAGLVIFKDGPLNMDQPADNISEMFRPFRKLLIKMRDLLRTLTKHELYQLEKLLCTNEEISLKEELICDANENDSSDVLPQEDHVVIVTTNVNTSNNSDNSDSRVDDSPNDELRHESETRDNRNSSFYSNRIIDSNRLHADVEDDVSENDDDDDPSNVLKDSLVTTDCASGYLIPNTNFGNLLQTNEAPLTDSFIATDEELKLGTSSNARIEQILSETNQKLADSGLGTANPSVDNSPELDTERPITSRSACESSEEGEIDEYDNEEDDEDSDNNLSNQQLMDPGSSAGTSQSAGKPYRTHKQQHHHRHRRSSGSIMSATSSRKYNSKHHKASASASVIVPSNQGTSSKTYSNCDTSPSSGNQSECSSTSSTTGESSQDVAMAIRAAGRIKFKTTENLLHRLFVCIAGVADQLQTNFAADLRQMLKSVFIINSSPPEPEEPPELAPTSSDKPKEPDPTDLFEFRASEQDVITPGQNSGGSSQSIYSAEEVNPEDPHDSVFGSPGTSPIRASSAPRTMMTTAESGGVTVNVSVSVVTGGGSSSSRNVQERSVSLSETSIVVENNGGATDSNLRDSHRRHSAIGSKGEYGRSRSSPNSPVNGTSAEERRMPEAPPRWIPDGDAPRCMACASSFTPFRRRHHCRNCGGVFCGVCSSASAPLPKYGLTKAVRVCRDCYVREVGT
What is the function of this protein?
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
What are the official names of this protein?
Lateral signaling target protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the lst-2 family.
Protein: TOP3B_MOUSE
Sequence: MKTVLMVAEKPSLAQSIAKILSRGNMSSHKGLNGACSVHKYTGTFAGQPVHFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYVVLWLDCDKEGENICFEVLDAVLPVMNNAHNGEKTVFRARFSSITDTDICNAMTRLSEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVHTDKEESLLLDWDRVRVFDWEIAQMFLNMTKLEKEAWVEATSRKEKAKQRPLALNTVEMLRVASSALGMGPQHAMQIAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADSVKQLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPEHFTCMGKTVISPGFTEIMPWQSVPLEESLPTCQKGDTFTVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYHQVLGHTLDIFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPTCQHSLSMLGIGQCVECENGVLVLDPTSGPKWKVACNTCNVVAHCFENAHRVRVSADTCNTCEAALLDVDFNKAKSPLPGNETQHTGCIFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRGRRPPGKPNPRRPKDKMSALAAYFV
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).  Possesses negatively supercoiled DNA relaxing activity.
What are the official names of this protein?
DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: RL27_MYCSK
Sequence: MAHKKGASSSRNGRDSAAQRLGVKRFGGQVVKAGEIIVRQRGTHFHPGVNVGRGGDDTLFATAPGSVEFGSRRGRKTVNIVPVARPEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: Y1048_LISW6
Sequence: MANKKKDHREEAVELLKQDAKRILQLIKVQMDNLTLPQCPAYEEVLDTQMYGLSREINFATRLGLIEPEEGKNLISALEKELSTLHELSMSKK
What are the official names of this protein?
UPF0358 protein lwe1048.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.