PharMolix/UniProtQA huggingface dataset:
Protein: AAEB_SALA4
Sequence: MGIFSIANQHIRFAVKLACAIVLALFIGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAALIIIISMIRAPLLMILVCCVWAGFCTWISSLVRIENSYAWGLSGYTALIIVITIQTEPLLTPQFALERCSEIVIGIGCAILADLLFSPRSIKQEVDRELDSLLVAQYQLMQLCIKHGDSEEVDNAWGDLVRRTAALEGMRSNLNMESSRWVRANRRLKALNTLSLTLITQSCETYLIQNTRPELITDTFRELFETPVETVQDVHRQLKRMRRVIVWTGERETPVTLYSWVGAATRYLLLKRGVISNTKISATEEEILQGEPVVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGNGAMVMIAVVTSLAMRLPNPRMVCIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFIGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCMLAFIVILLVRDKSKDRTGRVLLNQFVSAAVSAMTTNVVRRKENRLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSVFHRQLRRTADHVISAGSDDKRRRYFGLLLDELDIYQEKLRIWEAPPQVTEPVKRLTGMLHKYQNALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEPA_CHLPB
Sequence: MSSSTTVVDTIRNFCIIAHIDHGKSTLADRFLEATDTLLHNQATAQVLDDMDLERERGITIKSHAIQMRYTSADGEEYILNLIDTPGHVDFSYEVSRSLAACEGALLVVDATQGVEAQTIANLYLAVEAGLEILPVINKIDLPSSDVEGVSQQIIDLMGVDRSEILEVSAKAGIGVDALLEAIIKRVPAPVDQRSKPLRALIFDSVFDAYRGAIVYLRIVDGMLNKGDRVRFFANEKVFLADEIGTMGLKRQPVKTLGAGDVGYLICSIKDVRDAKVGDTVTLADAPAKERLSGYKDVKPMVFSGLYPVNSNEFEDLRESLEKLSLNDASLVYTPETSAALGFGFRCGFLGLLHMEIIQERLEREYQVNIITTVPNVEYRVISSEGGTHVVDNPSKMPDAGFIEKIEEPYVSVQIITLAEYIGNIMKLAMERRGEYKNTDYLDTTRVNLHFEFPLAEIVFDFHDKLKSVSKGYASMDYEYIGYRDSDLVKLDVLLNGESVDALSTIVHRSKAYEWGRRLCQKLKSIIPRQMYEVAIQAAIGSRVIARETISAMRKNVLAKCYGGDISRKRKLLEKQKEGKKRMKQVGRVEIPQEAFLAVLNMDDQ
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BAIP2_CRIGR
Sequence: MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTFAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQAEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPVWQQACADPNKIPDRAVQLMQQIASSNGSILPSTLSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQENVPVMNGVAGPDSEDYNPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAVPPPDYGTSSRAFPTQTAGTFKQRPYSVAVPAFSQGLDDYGARSVSSADVEVARF
What is the function of this protein?
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins.  Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling.  Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex.  Plays a role in neurite growth.  Acts syngeristically with ENAH to promote filipodia formation.  Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.  Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity).
What are the official names of this protein?
Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI-associated protein 2, BAI1-associated protein 2, Insulin receptor substrate protein of 53 kDa, IRSp53, Insulin receptor substrate p53, Insulin receptor tyrosine kinase 53 kDa substrate, p58/p53.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity).
Protein: Y2962_CLOB8
Sequence: MARPTKFRRVEFFPEDDYFVPCGKPKCQIEEIALKVEELEAMRLKDIEELNQEECAEKMQVSRQTFQNIIDSARKKVVTALTEGKAIRISGGHYTTKLCKFKCAECETIYEINYDQDRAVCPSCGSDKVMCNKKAGFCKNWCKGNNIE
What are the official names of this protein?
UPF0251 protein Cbei_2962.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: MNME_STRPD
Sequence: MSITKEFDTITAISTPLGEGAIGIVRLSGTDALAIAQSVFKGKNLEQVASHTINYGHIIDPKTGTIIDEVMVSVMLAPKTFTRENVVEINTHGGIAVTNEILQLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMTIAVKQLDGSLSQLINDTRQEILNTLAQVEVNIDYPEYDDVEEMTTALLREKTQEFQSLLENLLRTAKRGKILREGLSTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNIKGVPLKLVDTAGIRETDDLVEQIGVERSKKALQEADLVLLVLNASEKLTDQDRALLNLSQDSNRIILLNKTDLEQKIELEQLPDDYIPISVLTNQNINLIEDRINQLFFDNAGLVEQDATYLSNARHISLIEKAVQSLEAVNDGLALGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_PSEPW
Sequence: MSIKSDKWIRRMAQEHGMIEPFVERQVRGEHDSRVISFGVSSYGYDVRCADEFKVFTNINSATVDPKNFDAGSFVDVKSDVCIIPPNSFALARTVEYFRIPRNVLTICLGKSTYARCGIIVNVTPLEPEWEGHVTLEFSNTTTLPAKIYANEGVAQMLFLESDEECEVSYKDRGGKYQGQRGVTLPRT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: AT1B2_HUMAN
Sequence: MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT
What is the function of this protein?
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta-2, Adhesion molecule in glia, AMOG, Sodium/potassium-dependent ATPase subunit beta-2.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: DBP4_MAGO7
Sequence: MAHKGKAAPAKPPTSHKKEVKSLKRKRGQEELSTLRKAIDEFDLKSTPKAFAELPLSEPTAKGVRDSHFETLTDIQARAIPLALKGRDILGAAKTGSGKTLAFLVPLLEKLYREQWTQEAKLGALVLSPTRELAVQTFQVLRKIGRHHLFSAGLVIGGKSVREEAEALSRMNILIGTPGRILQHLDQTHGFDVDNLQLLVLDEADRIMDLGFQRDVDALVQHLPTTRQTLLFSATQSKKVSDLARLSLKDPEYVSVHAEATTATPSTLQQHYIVTPLPEKLDTLWGFIKANLKSKMVVFLSSGKQVRFVYESFRQMQPGIPLLHMHGRQKQLARLDVTKRFDSSKHACLFATDVIARGIDFTGVDWVVQVDAPEDTDDYIHRVGRTARYEREGKAVIFLDPSEEAGMLKRLERKKVPITKVTAKDSKKKSIRDELQSICWKSHDVKYLAQKAFISYARAVHRATERDEKHNENSDQVFKFDKLDLEGFAKSMGLAGAPQIKFQKGEDVKRMKNAPRAPLSSGSEDESGDDKPRRRKKDEVRTKADKMFERTNQDVLSKHYRNLVEDGENDEEEDFFTTKRVLRGDELDEAAGGAGAGLPTAKTIDLGGTELVLDSKRREKLIKSKKQLAKLKGKGQKLVFDDDGVAHPLYTLQDEDDFKQQGPAEALRKQFVEQEGDKVKEADIDDKALAKQKKREKKLKRKARERGEAEGNGGPQLAGGDDDDEDPLEMLRSLPMAGTTRDSGDDESEDERPKKKPKKWFQDDSDDERKPKSKVIELDHEPDTLEDYEAIAAGLLDD
What is the function of this protein?
ATP-dependent RNA helicase required for ribosome biogenesis.  Involved in the release of U14 snoRNA in pre-ribosomal complexes.  Required for pre-rRNA cleavage at site A2 (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: 3BP5L_BOVIN
Sequence: MAELRQIPGGRETPQGELRPEVVEDEVPRSPVAEEPGGGGSNSSEAKLSPREEEELDPRIQEELEHLNQASEEINQVELQLDEARTTYRRILQESARKLNTQGSHLGSCIEKARPYYEARRLAKEAQQETQKAALRYERAVSMHNAAREMVFVAEQGVMADKNRLDPTWQEMLNHATCKVNEAEEERLRGEREHQRVTRLCQQAEARVQALQKTLRRAIGKSRPYFELKAQFSQILEEHKAKVTELEQQVAQAKTRYSVALRNLEQISEQIHARRRGQPAHTPGQRRSSPVGAEAGPDGGEDADSGIIEGAEGGGLEEGVSLGPGAAPDTDTLSLLSLRTVASDLQKCDSVEHLRGLSDHTSLDGQELGPRSGGRGGRHQRSISL
What is the function of this protein?
Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
What are the official names of this protein?
SH3 domain-binding protein 5-like, SH3BP-5-like.
What is the protein family that this protein belongs to?
Belongs to the SH3BP5 family.
Protein: HLYAC_ECOLX
Sequence: MPTITAAQIKSTLQSAKQSAANKLHSAGQSTKDALKKAAEQTRNAGNRLILLIPKDYKGQGSSLNDLVRTADELGIEVQYDEKNGTAITKQVFGTAEKLIGLTERGVTIFAPQLDKLLQKYQKAGNKLGGSAENIGDNLGKAGSVLSTFQNFLGTALSSMKIDELIKKQKSGGNVSSSELAKASIELINQLVDTAASLNNVNSFSQQLNKLGSVLSNTKHLNGVGNKLQNLPNLDNIGAGLDTVSGILSAISASFILSNADADTGTKAAAGVELTTKVLGNVGKGISQYIIAQRAAQGLSTSAAAAGLIASVVTLAISPLSFLSIADKFKRANKIEEYSQRFKKLGYDGDSLLAAFHKETGAIDASLTRISTVLASVSSGISAAATTSLVGAPVSALVGAVTGIISGILEASKQAMFEHVASKMADVIAEWEKKHGKNYFENGYDARHAAFLEDNFKILSQYNKEYSVERSVLITQQHWDTLIGELAGVTRNGDKTLSGKSYIDYYEEGKRLEKKPDEFQKQVFDPLKGNIDLSDSKSSTLLKFVTPLLTPGEEIRERRQSGKYEYITELLVKGVDKWTVKGVQDKGSVYDYSNLIQHASVGNNQYREIRIESHLGDGDDKVFLSAGSANIYAGKGHDVVYYDKTDTGYLTIDGTKATEAGNYTVTRVLGGDVKVLQEVVKEQEVSVGKRTEKTQYRSYEFTHINGKNLTETDNLYSVEELIGTTRADKFFGSKFADIFHGADGDDHIEGNDGNDRLYGDKGNDTLSGGNGDDQLYGGDGNDKLIGGAGNNYLNGGDGDDELQVQGNSLAKNVLSGGKGNDKLYGSEGADLLDGGEGNDLLKGGYGNDIYRYLSGYGHHIIDDDGGKDDKLSLADIDFRDVAFRREGNDLIMYKAEGNVLSIGHKNGITFKNWFEKESGDISNHQIEQIFDKDGRVITPDSLKKALEYQQSNNKASYVYGNDALAYGSQGNLNPLINEISKIISAAGNFDVKEERAAASLLQLSGNASDFSYGRNSITLTASA
What is the function of this protein?
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by forming a pore.
What are the official names of this protein?
Hemolysin, chromosomal.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: MTNA_METTH
Sequence: MNMKTIEWKDGELVLIDQRKLPDSLEYFRCRDYRDVIYAIKNMVVRGAPAIGVTAAFGVAMAELAGEDVEVAAEEIKASRPTAVNLFWAVDRVMKSESPLDEAITMYMEDMETNRAIGRHGAGLIEDGDTVLTHCNAGALACVDYGTALGVIRAAWDDGKRLTVICDETRPVGQGARLSVWEMQQEGIPVKLITDVAAGYLMQTGMIDKVIIGADRIAEGGVANKIGSLMVALAAKRFNVPFYVAAPMSTFDTENSIYDIEIEERDPAEVLYYGGCRIAPQDTEAINPAFDIVPSDLISGIITEKGILDPL
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Putative methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, MTNA-like protein, aMTNA, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: RS9_SHEFN
Sequence: MSATQYYGTGRRKTSTARVFAKAGSGNIVVNQRPLDVYFGRETARMVVRQPLELVEMTDKLDIYVTVKGGGTTGQAGAIRHGITRALLQLDEALRPTLRSAGFVTRDARKVERKKVGLRKARRKPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: NUOCD_ACICJ
Sequence: MLTEFNSIPATEAEQGIVSDLVRTLGPISFTLQQTADRIPTIWIDRDIVHAVLRHLRDGATRRFQMLYDLTAIDERQRVHRDGLPKSDFTLVYHLVSFERNDDVRVKVPLAEGALEVQSIADIWPNANWYEREVWDMFGIGFAGHPTLFRILTPPTWTGHPLRKDYIARATEMGPYILTEEKERAEQEALRFNPEAWGMKRHSENSDFMFLNLGPNHPSVHGVFRIILQLEGEEIVDAVPEIGFHHRGAEKMAERQSWHTYIPYTDRIDYLGGVMNNFPYVMAVERLAGIEVPSRAQMIRIMLAELFRIASHLVFYGTMSQDVGQLSPVFYMFSDRERVFQIIEAICGFRMHPAWFRIGGVAADLPQGWDRMIRDYLGYQSKRLDEYDKLVMRNRLFKARTIGVGAYTLEEALDWGVTGPGLRACGLGWDYRRQRPYSGYDQLEFDIPICHNGDCYDRVVVHIEEIRQSLRIIRQCLDNMPPGPYKSDHRLTTPPLKERTMQDIETLITHFLNVSWGPVLPPGEAMVSIEATKGINGYYLVADGDTVSYRTRIRTPSFPHLQMIPLISRGAYVADLIAIIGSIDFVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RPO5_METBU
Sequence: MSKFSLLDHELIPHHEIMDEDDLKTVLTHYNVEREQLPKLKVTDPIALEIGAEPGDVVKVIRKSQTAGEALYYRYVIG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo5, DNA-directed RNA polymerase subunit H.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC196_BOVIN
Sequence: MTSASNSPESYLSSKTRSSKLDDNYLKELNEDLKLRKQELLEILKPLEDKNNLLFQKLMSNLEEKQRSLQIMRQIMAGKGNDDSSVIELIKEAEEMKQNLERKNKMLRKEMEMLWNKTFNTEEFSDEEKVLQIKNKTDLQDGKAPKTPSSSRKTKNELETLCAEKGKEIRKRLFLPPGKETEENGMGQVSGTSQHHSE
What are the official names of this protein?
Putative coiled-coil domain-containing protein 196.
Protein: DAPD_NITWN
Sequence: MPTASLETTINGAFDARETITPATRGEVRDAVDQALGLLDKGEARVAERAADGKWQVNQWLKKAVLLSFRLNDMSVIPGGPGNAAWWDKVPSKFEGWDENRFRDAGFRAVPGAIVRRSAFIARNVVLMPSFVNLGAYVDESTMVDTWCTVGSCAQIGKRVHISGGAGIGGVLEPLQAGPVIIEDDCFIGARSEVAEGVIVRKGAVLSMGVFLGASTKIVDRTTGEIFMGEVPEYAVVVPGALPGKPLSNGQLGPSTACAVIVKRVDERTRSKTGINELLRD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYD_PYRAE
Sequence: MYPKKTHWTAEITPNLHGTEVVVAGWVWELRDIGRVKFVVVRDREGFVQVTLKAGKTPDHLFKVFAELSREDVVVIKGIVEASKIAKSGVEIFPSEIWILNKAKPLPIDIWSETPDLATRLKWRSVDLKRPRNLVVFTVASAMLRSIREVLYGEGFVEVFTPKIIVTSTEGGAELFPVMYFERVAYLSQSPQLYKEQLTASLERVFEIGPAYRAEKHNTDYHLNEFISVDAEAAFMDYNDIMDILEKIMRRLASTVSEYAPKLEEVGIKALMELSNIPRVDYDEAVDRLRQLGYAVNWGDDFTVEMQKALMKYYGPVYFIVNFPASLRPFYTKRKDGEKSESYDLIINGIEVASGATRIHKRDELEEEMKKRGLDPRLFESHLSVFDYGMPPHAGFGLGFNRLVTALLGLDNVRHATLYPRDRYRVEP
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA(Asp) ligase, Aspartyl-tRNA synthetase, AspRS, Discriminating aspartyl-tRNA synthetase, D-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPX_HUMAN
Sequence: MEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
What is the function of this protein?
DNA-binding component of the Fanconi anemia (FA) core complex.  Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429).  In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA.  Stabilizes FANCM.  In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429).  In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631).  As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:20347429).  DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded.  Does not bind DNA on its own (PubMed:20347429).
What are the official names of this protein?
Centromere protein X, CENP-X, FANCM-associated histone fold protein 2, FANCM-interacting histone fold protein 2, Fanconi anemia-associated polypeptide of 10 kDa, Retinoic acid-inducible gene D9 protein homolog, Stimulated by retinoic acid gene 13 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the CENP-X/MHF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS.
Protein: TRHO_ARTS2
Sequence: MALNRIVLFYGFTPITDPDAVRLWQRALCEKLGLTGRILISKDGINATVGGELNAVKQYVKTTREYKGFHGIDVKWSDGGAEDFPRLSVKVRDEIVSFGAPGELKVDANGVVGGGTHLKPEELHRLVDAKKERGEEVVFFDGRNAFEAQIGKFKDAIVPDVATTHDFIKELESGKYDALKDKPVVTYCTGGIRCEVLSSLMVNRGFKEVYQLDGGIVRYGETFKDQGLWEGSLYVFDKRMHLEFSDEAKTIGECVRCSAPTSKFENCSNPSCRTLTLYCTECASSPETLRCPEGCAA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: CACO2_MOUSE
Sequence: MDQCPIPTLLEHGNFSQVLFNNVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKDQNKDSATQQEIQFKAYYLPKDVERYQFCYVDEDGLVRGTSVPFQFCPDPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKYADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEEEKASWEKEKASWEEEKASWEKEKAPWEVEKAPWKEVKAYWWNDLHR
What is the function of this protein?
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity).  Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity).  Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity).  Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity).  May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity).
What are the official names of this protein?
Calcium-binding and coiled-coil domain-containing protein 2, Nuclear domain 10 protein NDP52, Nuclear domain 10 protein 52.
What is the protein family that this protein belongs to?
Belongs to the CALCOCO family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
Protein: DXR_CHLTE
Sequence: MKSLSILGSTGSIGLSTLDVVRRHPERFSIAALAEGHDVEMLLKQIDEFRPSLVSVRDEASRERLKGMLGDHKPEILCGLEGAAEVAAVDGADMVVSAIVGAAGLVPTVRAIEAGKDIALANKETLVVAGQLVSDLVKKHDVKLLPVDSEHSAIFQSLVGHRTEDIERIILTASGGPFRKTPAEELKNVGPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFDMPAEKIGVVVHPQSIIHSMVEYIDGCVIAQLGVPDMRAPIAYALAWPERCETGIGKLDLTKVATLTFEEPDMERFPALRLAFDALKAGQTYPAVLNAANEIAVAAFLDKKIGFTDIAGTVDKTMQAHEAWTPITLEEYLQADKWARETARQLIG
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: YIDD_BLOFL
Sequence: MVSLPKLSAKIIIRLIYIYQIGISPILGHHCRFSITCSQYGINSIRNFGILKGCWKTCIRILKCHPFNKNDNTQ
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SPDS2_DATST
Sequence: MEVANHNNNNNGCTNDKESPCISSVLPGWFSEISPLWPGEAHSLKVEKILFQGKSDYQDVMVFQSTTYGKVLVLDGVIQLTERDECAYQEMITHLPLCSIPNPKKVLVIGGGDGGVLREVSRHSSVEQIDICEIDKMVVEVAKQFFPDVAVGYEDPRVNLHIGDGVAFLKNVPAGTYDAVIVDSSDPIGPAQELFEKPFFETIARALRPGGVVSTQAESIWLHMHIIEEIVANCREIFKGSVNYAWTTVPTYPSGMIGFMLCSTEGPAVDFKNPINPIDDESHGQTIGPLKFYNSEIHQASFCLPSFAKRVIETKGK
What are the official names of this protein?
Spermidine synthase 2, SPDSY 2, Putrescine aminopropyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
Protein: SUDHB_PYRFU
Sequence: MFKILRKERLAPGINLFEIESPRIAKHAKPGQFVMIRLHEKGERIPLTIADVDISKGSITIVAQEVGKTTRELGTYEAGDYILDVLGPLGKPSHIDYFGTVVMIGGGVGVAEIYPVAKAMKEKGNYVISILGFRTKDLVFWEDKLRSVSDEVIVTTNDGSYGMKGFTTHALQKLIEEGRKIDLVHAVGPAIMMKAVAELTKPYGIKTVASLNPIMVDGTGMCGACRVTVGGEVKFACVDGPEFDAHLVDWDQLMNRLAYYRDLEKISLEKWERERRMV
What is the function of this protein?
A bifunctional enzyme that catalyzes the reduction of elemental sulfur or polysulfide to hydrogen sulfide with NADPH as electron donor.  Also functions as a reduced ferredoxin:NADP oxidoreductase with a very high affinity for reduced ferredoxin.  Exhibits a broad specificity for various physiological and non-physiological substrates with varied reduction potentials such as methyl viologen, benzyl viologen, FAD, FMN, methylene blue, 2,6-dichlorophenolindophenol (DCIP), cytochrome C and ferricyanide with highest preference for benzyl viologen.  Does not reduce fumarate, succinate, nitrate, nitrite, sulfate, sulfite or protons.  Does not possess any hydrogenase activity or NADPH-dependent glutamate synthase activity.
What are the official names of this protein?
Sulfide dehydrogenase subunit beta, SuDH, Ferredoxin:NADP oxidoreductase, FNOR.
What are the subcellular locations of this protein?
Cytoplasm.