PharMolix/UniProtQA huggingface dataset:
Protein: ATPB_DICDH
Sequence: MSENLNREPELNIGYITQVIGPVIDAVFSAGQLPKIYNALEVKSKDGTTIICEVQQLFNDNRVRAIAMSATDGLQRGVEVIDTQAPILVPVGKATLGRIFNVLGQTVDNIEIGTGEDRLPIHRPAPSFTDLETKPAIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINESNLSESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDINRQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTEMGALQERITSTTQGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPVIVGSEHYDTAQLVKKTLQRYKELQDIIAILGIDELSEEDRLVVDRARKIERFLSQPFFVAEVFTGSPGKYVDLENTIKGFNMILNGELDVYQSIAFYLVGDINEAIAKAKTITN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RRF_COLP3
Sequence: MIDEIIEDAQDRMGKSIEALKTSLTKIRTGRAHASLLDNIVVEYYGMDTPLNQVGNVSVPDARNLSITVFDKSMISAVEKAIMKSDLGLNPQSNGTLIRIPLPPLTEERRKDLVKVVRGEAEGGKVAIRNIRRDANSDFKSLLKEKEISEDDHHQAEDSIQKITDVFVKQVDEVLVKKEAELMEI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMK2_SHEB8
Sequence: MKIGILSQFPQLYSTQRLVEACQSRGHEAVVINTLNCYMNINSIKPSIHYEGTELVGFDAIIPRIHASVTFYGCAVVRQFEMMGVYAANDSISIARSRDKLRALQLLSRKGIGMPVTGFANKPNDIPDLINMVGGAPLVIKLLEGTQGIGVVLAETKTAAESVIEAFLGLKANILVQEYIKESNGSDIRCFVVGDKVIASMKRQGPEGDFRSNLHLGGCGEVVKITAVERKMAIAAVKAMGLVVAGVDILRSNRGPLILEVNSAPGIEGIEQTTGISVTEPIVEYIEKMVAARKTNRPIIA
What are the official names of this protein?
Probable alpha-L-glutamate ligase 2.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: NUOH_ECO7I
Sequence: MSWITPELIEILLTILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLAFAIVPVSPGWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMTDIVNSQAHVWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTISALMVTLFFGGWQGPLLPPFIWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKICLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BRD3_HUMAN
Sequence: MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
What is the function of this protein?
Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114).  Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).
What are the official names of this protein?
Bromodomain-containing protein 3, RING3-like protein.
What are the subcellular locations of this protein?
Nucleus. Note=Detected on chromatin.
Protein: ADHX_SAAHA
Sequence: ASGVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRVKIIATAVCHTDAYTLSGADPEGSFPVILGHEGAGIVESVGEGVTKFKPGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGVMPDGTSRFTCKGKQVLHFMGTSTFSEYTVVADISLTKINASAPLDKVCLLGCGVSTGYGAALNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDLNKDKFAKAKEFGATECISPADFKKPIQEVLIEMTDGGVDYSFECIGNVGVMRAALEACHKGWGVSVIVGVAAAGQEIATRPFQLVTGRTWKGTAFGGWKSVESVPKLVDEYMSKKMKVDEFVTHTLPFEQINEAFELMHAGKSIRSVLKF
What is the function of this protein?
Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
What are the official names of this protein?
Alcohol dehydrogenase class-3, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMA_STRPN
Sequence: MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPILVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIFQQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYINYLSQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS
What is the function of this protein?
Required for induction of competence.  Seems to transport the competence-stimulating peptide (CSP).
What are the official names of this protein?
Transport/processing ATP-binding protein ComA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Competence factor exporter (TC 3.A.1.112.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOC_STRPB
Sequence: MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPEREGLFDEVIFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRAKVRRERMGHIELKAPVSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEPKSLLTEREYREKLQEYGHGSFVAKMGAEAIQDLLKRVDLAAEIAELKEELKSASGQKRIKAVRRLDVLDAFNKSGNKPEWMVLNILPVIPPDLRPMVQLDGGRFAASDLNDLYRRVINRNNRLARLLELNAPGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVAKEYAGNVKAAKRMVERGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNADFDGDQMAIHVPLSEEAQAEARLLMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEDAGREGEGMIFKDKDEAVMAYRNGYAHLHSRVGIAVDSMPNKPWKDSQRHKIMVTTVGKILFNDIMPEDLPYLQEPNNANLTEGTPDKYFLEPGQDIQEVIDGLDINVPFKKKNLGNIIAETFKRFRTTETSAFLDRLKDLGYYHSTLAGLTVGIADIPVIDNKAEIIDAAHHRVEEINKAFRRGLMTDDDRYVAVTTTWREAKEALEKRLIETQDPKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLLIRAITDGKEVTETLEERLQGRYTRKSVKHPETGEVLIGADQLITEDMARKIVDAGVEEVTIRSVFTCATRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRIQEIFEARNPKGEAVITEVKGNVVEIEEDASTRTKKVYVQGKTGMGEYVVPFTARMKVEVGDEVNRGAALTEGSIQPKRLLEVRDTLSVETYLLAEVQKVYRSQGVEIGDKHVEVMVRQMLRKVRVMDPGDTDLLPGTLMDISDFTDANKDIVISGGIPATSRPVLMGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNIEPQAMNEIEVIDHTEVSAEAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RS7_PROM1
Sequence: MSRRNAAEKRPVLPDPQFNNRLASMMVHRLMKHGKKSTAQKILSDAFGLINERTGSDPIELFETAVKNVTPLVEVRARRVGGATYQVPMEVRQERGIAMALRWLVNFSRSRNGRSMAQKLAGELMDAANEAGNAVRKREETHKMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: TX1BA_ECTTU
Sequence: GVKEKLLAVLRKACPVIEKLAKKCHGTVATLKKACSLIH
What are the official names of this protein?
U1-ectatotoxin-Et1b subunit A, U1-ECTX-Et1b subunit A, Ectatomin-Et2 subunit A.
What is the protein family that this protein belongs to?
Belongs to the ectatomin family. Ectatomin-Et subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: MNME_ECO7I
Sequence: MSDNDTIVAQATPPGRGGVGILRISGLKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNDVIADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWSEFIARLPAKLPITVVRNKADITGETLGMSEVNGHALIRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLAEELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_PARUW
Sequence: MFSFNLLTQYIIMRSLKKFFVKTYGCQMNELDSEIMIGQLENRGLTRSHDENDADLLIFNTCSIRDLAERKVMGKLGKLGLTKQSQAIIGVTGCMANAKKDSLFQKLPHIDFVLGTNNIHDLNHVLDEVLASGKQSIRTDDHFEFELDYLNAKREDQIKAYVSIIRGCDKFCTYCVVPYTRGSEVSRAPENILEECRHLVNQGYKEITLLGQNVNSYGKDKLEWKCLFHDLLYQLDKIPGLERVRFMTSHPVDISKELMEAIRDLKTLCEFVHFPLQAGSNRVLKKMHRIYTVEQYLEKVQMLKEIVPNVALGTDIIVGFPTETEEEFQETYRLLKEIEYSVAFLFSYSPRKGTPAMRWRDDVPEEVKQDRLQRLLQLQDTIYMKHRQAFLGQTVEVLVERRNFKDDRLVKGRTRCWKNVLFTGGDELVGTMQQVKIHGYSHQTLLGDLQ
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG047_VACCC
Sequence: MPIFVNTVYCKNILALSMTKKFKTIIDAIGGNIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKNFIAKHFLELEDDIIDNFDYLSMKLILESDELNVPDEDYVVDFVIKWYIKRRNKLGNLLLLIKNVIRSNYLSPRGINNVKWILDCTKIFHCDKQPRKSYKYPFIEYPMNMDQIIDIFHMCTSTHVGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYATGIPANNKLYVVGGLPNPTSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVMGGHSETDTTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVGRNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNHHTYSWNIWDGK
What is the function of this protein?
Might have a role in the suppression of host immune response.
What are the official names of this protein?
Immune evasion protein OPG047, Kelch repeat protein.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG047 family.
Protein: SSRP_SACD2
Sequence: MSKANKKKKPQSSTIAQNKRARHDYFLETKFEAGVALLGWEVKALRAQRGQMTESYVLVQNGEAWLQGAQIQPLPQACTHYVTEPARPRKLLLNRRELNKIAEAKDQKGYTIVATSLYWKAHMVKCEIAIAKGKQLHDKRQTEKEREWNIQKQRVLYDK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MUTL_BORAP
Sequence: MNKIRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFLEEGGIQKILIIDNGSGISQEDLKICYLPHTTSKISSEEDLRKIETLGFRGEALSSIAICSNISITSSTTGNESYQIEVENGIEKCFKKQPAINGTIVDVTKIFHNFPARKRFLKQEPIETKMCLKVLEEKIITHPEINFEINLNQKLRKIYFKESLIDRVQNVYGNVIENNKFKVLKKEHENIKIEIFLAPANFSKKSKRHIKTFVNRRPIDQKDLLEAITNGHSRILSPGNFPICYLFLEINPEYIDFNVHPQKKEVRFFNLPFLFKLISDNINNFFDKDTNNYHDVIIKRQLTDDDHLIEMINQSENFNKTSTYDVPQNKNLETEDNTNEPNKNMIQKDVGLRKYNSIIENRPSLKENITNIFSDSFLEFEEPPNKNEEEDIKFNYIGQIFSEFLIVEKANEIYFIDQHAVHEKIIYEKLRNSKKTIQKLLIPIEFTIVDKNIEKIIDSEIEEYKKMDIIISKIGSEKYQLESIPNICNQYENTLINFFQSRRSRTINSLESDLYATIACRKAVKTNDILSVEFSKYLINEFFKLEIKHCPHGRKIYYKISKFELEKKVDRA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: ULA1_MACFA
Sequence: MAQPGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKSPENLLDNDPSFFCRFTVVVATQLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
What is the function of this protein?
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme.  E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP.  E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.  Necessary for cell cycle progression through the S-M checkpoint.  Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity).
What are the official names of this protein?
NEDD8-activating enzyme E1 regulatory subunit, Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
What are the subcellular locations of this protein?
Cell membrane. Note=Colocalizes with APP in lipid rafts.
Protein: PPR32_MOUSE
Sequence: MMGKLPLGVVSPYVKMSSGGCSDPLKFYATSYCTAYGREEFKPRLGSHVGTGYKSNYRPLVSYQPHLDTLDNPAIGQQIRDTSKSVTSQSYSPLEVPDGKQPLPWNLHQTTSSYGREKLNPGPHSKEVRKVHFDTQDHGPQTITGLEPKEVPLIHQQQGKGSTEWENSHYGPRFMTSEYNSKYIKESPNHPDLLLKKTIGSKEETGFTEESTKNPIVFQPPSQAFPGDPVLHPGRSITKSDYLPVTHPQGSDFLPVLSRGSDRDTGFSRVNERTLNPRVPTPAPQPASMSHRSYQPPQRMQQTNVALLGRESVGNKEPTGFTLNNPSYVRSSYEQDRDQRYLTTYNQGYFENIPKGLDREGWTRGGIQPQKAGAYALSELNNHTLMDSTPNPTETLRHLHPHVGRTLASVDPFYRDMPHSSRYPASS
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 32, Protein IIIG9.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm. Note=Localized to the cilia of polarized ependymal cells during development and at the adult stage. Preferentially locates between the peripheral microtubules of the axoneme and the ciliary membrane.
Protein: KDSB_PARUW
Sequence: MKHAEMTGQIIGIIPARYGSTRFPGKPLASILGKTLLQRTYENSLRASALSDLIVATDDERIFEHVRSFNGKVVMTSEQCPTGTDRLAEVLSLYPEWMHATAIVNIQGDEPCLNPLTINLAVQALVNDPQGQVSTIVTPLLDEEEAKNSSIVKCVMDQQGNALYFSRALIPSNKTNSFKNGAIYFRHLGLYVYRPSFIINYQKLPSTPLQLEEDLEQLKVLEHGYRIKVAIVDQANIGVDTPEDIHKVEEWLCKQNTFL
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZNUC_CERS4
Sequence: MTLIAAHHLAVRRGRDEILSDVSLSVAPREIVTIVGPNGSGKSTLLRALLGILPAAAGRVSRRPGLRIGYVPQRLQVDGTLPLTAARFLSLPRRRAPAEVAAALERVGVPEVADRQLADLSGGQFQRVLLARALLTEPELLMLDEPTQGLDQPGEAAFYRLIEEVRSTTGAAILMVSHDLHVVMAASDRVICLNRHVCCEGTPRVVSNAPEYRALFGHGTQGALALYRHEHDHDHTHDHSHHA
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TAD3A_XENLA
Sequence: MSELKDCPLQFHDFKSVDHIKLCPRYTAVLSRSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGKEHELGTPIKHSKPKKQKLDGKVSHASGPGPGRPKSRNMQQKMQEYEFTDDPVDVPRIPKNDAPNRFWASVEPYCADITNDEIKVLEDLLKTPEDEADYYKIPPLGKHYSQRWAQEDLLEEQKDGARAALSGDKKKGILGPLAELDSKDVDSLLKKSDSQHDQPEDGCPFGHLTQRLLQALVEENIISPVEDSPIPEISGKESGTDGASTSPRSQNKPFSAPHTKSLEVRVKEELIAQGLLESDDRPADDSEDEVLAELRKRQAELKALSAHNRAKKQELLRLAKEEMNRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKALKERESILKLLDG
What is the function of this protein?
Functions as a component of the PCAF complex.  The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context (By similarity).
What are the official names of this protein?
Transcriptional adapter 3-A, ADA3 homolog A, Transcriptional adapter 3-like A, ADA3-like protein A.
What is the protein family that this protein belongs to?
Belongs to the NGG1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS18_BACAC
Sequence: MAGRKGGRAKRRKVCFFTSNGITRIDYKDVDLLKRFVSERGKILPRRVTGTSAKYQRKLTVAIKRARQMALLPYVGE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: URED_NITOC
Sequence: MKKIAVFKQMPCEAADAPPAKTDLLPLSWPAKLELGYQRVKMRTVPVLRRHQGPLRVQKHLYPEGPAVCQHMILHPPGGIAGGDTLDIQIHAGSHAWAQLTSPGAAKWYRSEVSLARQNLALSTEPGGILEWLPQETIFFAGCQTALDTTIDLAEDAKVIAWDIIALGRPASGERFNSGRIYQRFRLRRNGRLLWSERMQLLGGSRLLESPIGFAGYPVAGTLLASGELNDQQLTACRSLPIEGGRGGLSQLPGLVVARFLGEETEAARNWFIALWQELRPALLGRSVSIPRIWNT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATC1_HUMAN
Sequence: MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHVKALRVFVESVLRYGLPVNFQAMLLQPNKKTLKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit C 1, V-ATPase subunit C 1, Vacuolar proton pump subunit C 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase C subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein.
Protein: OCAD1_BOVIN
Sequence: MNGRADFREPNAEVPRPIPHIGADYIPTEEERRVFAECNDESFWFRSVPLAATSMLITQGLISKGILSSHPKYGSIPKLIFACIMGYFAGKLSYVKTCQEKFKNLENSPLGEALRSGQARRSSPTGHYSQRSKYDSNVSGHSSFGTSPAADNLEKEMLPHYEPIPFSASLNESTPTGITDHIAQGPDPNTEESPKRKNITYEELRNKNRESYEVTLTHKTDPSVRPMQERMPKKEVKVNKYGDTWDE
What is the function of this protein?
Maintains stem cell potency (By similarity).  Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity).  May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity).
What are the official names of this protein?
OCIA domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the OCIAD1 family.
What are the subcellular locations of this protein?
Endosome.