PharMolix/UniProtQA huggingface dataset:
Protein: OBG_BUCAI
Sequence: MKFIDQAIIHVIAGNGGNGCVSFRREKYIPKGGPDGGNGGDGGNIWLEANNNLNTLIDLRFKKKFQAQNGQNGSSRKSSGKKGDDIKIHVPIGTKVINYQTREIIGDLIQHKQKMLIAKGGWHGLGNARFKSSTNRTPRQSTLGSIGEKRDIQLELMLLADVGTLGMPNVGKSTLVTNISGAKTKISDYPFTTLHPVLGSVNIQKNKKFIIADIPGIIKGASYGAGLGIRFLKHLERCKLLLHIIDLVPQNNCHPSDNIKTVLNELKKYSLKLYNKPRWFIFNKIDLLSVEELNQIIKEIIFQFKIHEKYYLISSMKKIGIKKLCSDITKYLKK
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP142_HUMAN
Sequence: MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 142, G-protein coupled receptor PGR2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MCPA_PSEAE
Sequence: MRESLGVSLPSRPLLLKLGLLSLPWALCAGLHAVGLGVWLVLALGWFASLAMLVLLLRAPRQAVANANPQADAASPAWSAAQRALADETAQLDGHARQIDELLHSAIRQLSDSFHGLAERIDTQRGLSHSLIERYDGRGQVDEGINFQDFVRTTQQTLSLFVEATLETSRTSQQLVERMDQVRLKITEILQSTQDMDAIAKQTNLLALNAAIEAARAGESGRGFAVVADEVRALSTRSTEFSAAIRKHVDVVHHEIQDAESAISQLADKDMSFALDSKHKIQGMLDDLEAMNRHTLKVIHELDRLSLEVGQGVDAAVTALQFQDMGSQLLGQMRKHHARLGAFALGLGALEARPRQEWPERVAREVEELRRPLPSPVSQNSVNVGEVELF
What is the function of this protein?
Involved in chemotaxis.  Required for an optimal chemotactic response.
What are the official names of this protein?
Methyl-accepting chemotaxis protein McpA.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PA2AB_DABSI
Sequence: MCLIGVEGNLFQFARLIDAKQEAFSFFKYISYGCYCGWGGQGTPKDATDRCCFVHDCCYARVKGCNPKLVEYSYSYRTGKIVCGGDDPCLRAVCECDRVAAICFRENMNTYDKKYMLYSIFDCKEESDQC
What is the function of this protein?
Heterodimer (A and B chains): snake venom phospholipase A2 that shows a moderate PLA2 activity (1377 umol/min/mg).  Acts as a presynaptic neurotoxin.  In vivo, induces edema and produces neurotoxic symptoms in mice.  It exhibits indirect hemolysis and a strong myonecrotic activity and is cytotoxic.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 daboiatoxin B chain, DbTx-B, svPLA2, Acidic phospholipase A2-II, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DHRS3_HUMAN
Sequence: MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT
What is the function of this protein?
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
What are the official names of this protein?
Short-chain dehydrogenase/reductase 3, DD83.1, Retinal short-chain dehydrogenase/reductase 1, retSDR1, Retinol dehydrogenase 17, Short chain dehydrogenase/reductase family 16C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PSD1_CLOAB
Sequence: MIKYYNRKTKQYEIEKVAGENYLNWTYSSPIGMSFLEALIKKKAFSSIYGSFCDSKISKGKVKKFIDSFDIDILESEKKPEAFKSFNDFFTRKLTKEARPFSTNKEILISPGDGRLLVYENIDLDNLVEIKGMGYSLKELIKDEKISSKYKNGICMILRLCPTDYHRFHFVDSGVCSATSKIKGSYYSVNPIALNKVKRLFCENKREWSILKSDNFKDILYIEVGATCVGSIIQTYKENTKVNKGDEKGYFKFGGSTVVLFFEKDSVKIDEDILEQTRLGYETKVFMGESIGKK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme 1.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type II sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PGK_THIDA
Sequence: MAFIRVTDLDLAGKRVFIRADMNVPVKDGKVTSDARITASMRTIEHCMRAGAKVMVTSHLGRPTEGEFKEEDSLKPVVDVIAQKLGKNVRLIREWTEGGFDVANGELVVLENCRVNKGEKKNVDETAKKYAALCDVFVMDAFGTAHRAEASTHGIAKFAPTAAAGILLTEELDALAKALANPARPMVAIVGGSKVSTKLTVLEALSEKVDQLVVGGGIANTFLAAMGKNVGKSLCEHDLIPTAKTLIEKMAARGASIPIAVDVVCGKKFDANEPAVLKSADEVADDDMIFDIGPKSAQELADIIAKAGTIVWNGPVGVFEFDQFGEGTKTVSMAIANAPGFSLAGGGDTIAAIQKYDIYDKVSYISTAGGAFLEYLEGKVLPAVAILEERAQG
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_NEIMB
Sequence: MRDKIKLESSAGTGHFYTTTKNKRTMPGKLEIKKFDPVARKHVVYKETKLK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: ORC2_MOUSE
Sequence: MSTLQLKETKVPSVQFVGDDDVLSHILDREGGTKLKKEKAQLLVNPQKVIKKADCELEKSDLEVLEDQNYVKVLGRNIQESLGNGSAKDGRNKVYSFQQRKHPEEMTKLALELAKTSGKKDPLDSNDPEITKNIAQKSKGHSTSEKAPLVNNNKTEFLSTQPHNLRKRIIASRSHYDSESEYSASSSEDDEEATKDEEEDTNVARLSQKSQGQNRLLPAPVSKETLPKKKKRDKASDLVEEYFEAHSSSKVLTSDRTLQRLRRARVDQKTLHNLLRKFVPSFSAEIERLNQQHEKLFHKWMLQLHLGFNIVLYGLGSKRDLLEKFRTTMLQDSIHVVINGYFPGVSVKSILNSITEDVLSHVGTFQSVLDQRDWIINRFKEDSSLELFLLIHNLDSQMLRGDNSQQILGQLSSLHNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKFQLDNQDSPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGILADFLEKEEEEA
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  DNA-binding is ATP-dependent.  The specific DNA sequences that define origins of replication have not been identified yet.  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).  Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3.  Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation.  Also stabilizes ORC3 (By similarity).
What are the official names of this protein?
Origin recognition complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the ORC2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KYNB_ACIAC
Sequence: MTTPRMLWDISAPVHAGSPVFPGDTPYSQQWCATIGPQCPVNVSALAMSPHVGTHADAPLHYDPQGATIGDVPLDAFIGPCRVIHAIGRGPLVAWEHIAHALGADRPALPQRVLVRTYERMPLDRWDAALAAYAPDTIERLADLGVVLVGIDTASIDPADSKSLDSHQVIRRRGLRVLENLVLDEVPEGDYELIALPLKLTTADASPVRAVLRTPA
What is the function of this protein?
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
What are the official names of this protein?
Kynurenine formamidase, KFA, KFase, Arylformamidase, N-formylkynurenine formamidase, FKF.
What is the protein family that this protein belongs to?
Belongs to the Cyclase 1 superfamily. KynB family.
Protein: NOP10_THEGJ
Sequence: MRFRIRKCPNCGRYTLKEICPVCGAKTKVAHPPRFSPEDPYGEYRRRWKREVLGIEVRK
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: NCPP_SALG2
Sequence: MHQVISATTNPAKIQAILQAFEEIFGEGSCHITPVAVESGVPEQPFGSEETRAGARNRVDNARRLHPQADFWVAIEAGIDDDATFSWVVIDNGVQRGEARSATLPLPAVILDRVRQGEALGPVMSHYTGIDEIGRKEGAIGVFTAGKLTRSSVYYQAVILALSPFHNAVYR
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: LEUC_HAHCH
Sequence: MAGKTLYDKLWDSHVVKQRDDGSALIYIDRQLLHEVTSPQAFEGLRLAGRKPWRVDANLATPDHNVPTTERSAGVQGIEDPISRIQVQTLDENCEEFGIVEFKMLDKRQGIVHVIGPEQGATLPGMTIVCGDSHTSTHGAFAALAHGIGTSEVEHVLATQCLVQKKMKNLLIKVNGQLARGVTAKDVILAIIGEIGTAGGTGYAMEFAGEAIESLSMEGRMTICNMAIEAGARAGLVAVDDKTIEYVKGRPYSPKGELWDKAVAAWRDLKSDSDAVFDKVVELNGADIEPQVTWGTSPEMVAGVSGSVPDPEKAEDATAKEGISRALKYMGLQAGAAITDIKLDRVFIGSCTNSRIEDLREAAAVVKGRKVAANVKQALVVPGSGLVKEQAEQEGLDKIFIEAGLEWREPGCSMCLAMNADKLGQGEHCASTSNRNFEGRQGFGGRTHLVSPAMAAAAAVFGHFVDVRELI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: ESM1_HUMAN
Sequence: MKSVLLLTTLLVPAHLVAAWSNNYAVDCPQHCDSSECKSSPRCKRTVLDDCGCCRVCAAGRGETCYRTVSGMDGMKCGPGLRCQPSNGEDPFGEEFGICKDCPYGTFGMDCRETCNCQSGICDRGTGKCLKFPFFQYSVTKSSNRFVSLTEHDMASGDGNIVREEVVKENAAGSPVMRKWLNPR
What is the function of this protein?
Involved in angiogenesis; promotes angiogenic sprouting.  May have potent implications in lung endothelial cell-leukocyte interactions.
What are the official names of this protein?
Endothelial cell-specific molecule 1, ESM-1.
What are the subcellular locations of this protein?
Secreted.
Protein: TMCAL_FERNB
Sequence: MRVLGIVVEYNPFHFGHLHHLEEAKKLINPDYVVAVMSGNFCQRGEPAIVNKFARTEIALKNGVDVVFELPVVYAIQDAGGFALGSVGVLDRTGVVTDIVFGSESGDVTFLRKVANLLTNQTPEFEKTFKRHLKMGYSYPNARKYALMDVLSNDVEKLSKSNDILGIEYIKALIKYSSDIQPHVIKRIGADYNDEQFKGKFSSASAVRKAIKENKFEQTKEALPEWTFKILEREFSEGRGPVFLEYFDFVIAMFRKLKREDFERIYSFNEGLDLRFYESARESGNLQDFVERVKAKRFTYSRIRRAIFHVLFDMEKSFVELSNEKGPQYLRVLGFTKRGRELLKAMKKNSKVPIISTASLYRNVLEEAKKKIAEGKVSWEIDESLYIWQFERDLLASDIYTFLYPNKFQRKAGMDFEYKVIEMLG
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_GLAP5
Sequence: MNSWTDAIGEEKTQPYFQHILQYVHQERLVGKVIYPPQNEVFSAFALTEFKDVKVVILGQDPYHGPNQAHGLSFSVKPGIVPPPSLVNMYKELSQDVGFQIPSHGYLIEWAKQGVLLLNTVLTVEQGKAHSHANIGWETFTDKVIHQLNLHRENLVFLLWGSHAQKKGQFIDRSRHCVLTAPHPSPLSAHRGFLGCRHFSKTNDYLRSHGVEEINWQLPL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXA_SHIF8
Sequence: MKIITCYKCVPDEQDIAVNNADGSLDFSKADAKISQYDLNAIEAACQLKQQAAEAQVTALSVGGKALTNAKGRKDVLSRGPDELIVVIDDQFEQALPQQTASALAAAAQKAGFDLILCGDGSSDLYAQQVGLLVGEILNIPAVNGVSKIISLTADTLTVERELEDETETLSIPLPAVVAVSTDINSPQIPSMKAILGAAKKPVQVWSAADIGFNAVDAWSEQQVAAPKQRERQRIVIEGDGEEQIAAFAENLRKVI
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixA.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: URED_SYNS3
Sequence: MQRLDPWHGTCNLQFVAGSSGSQFQGGCTAPLKLMRAERGENGRCELPLLHTAGGLVGGDQLSINLGLRPNSRCLLTSVAAQKIYGSIGRSQLHPLGTWARQQVSAELDADSDLEWLPQELVLYADALFEQNLSVTLPMDGSFLSAEIVRLGRTAANETLGQGCWRSDVQIQRQTSEGRRWELVDRLEISDDALKGFHGLNQQPVFGTLVWAAPFPLQTTKINNLLDDIRQDRKALEGQMHCGALPQGLIARYSGFSSRDARFWFSRIWARTRQARNLASPKIPRVWPLQEYPLRP
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_YERE8
Sequence: MQNHNNRIVITPGEPAGVGPDLVIALAQQDWPVELVVCADPALLLTRASQLNLPLQLREYQQDKPALAQLAGTLTILPVKIAAEVIPGQLDVKNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCSRVVMMLATEELRVALATTHLPLLAVPGAITQTSLHEVISILDNDLKTKFGISQPQIYVCGLNPHAGEGGHMGHEEIETIIPALATLRQQGINLIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFITALNLAIKMINNSNE
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_PSEMY
Sequence: MRIKLIAVGSRMPRWVEEGWQEYVKRLPAELPLELVEIPLNTRGKNADVARLIRQEGEAMLSKVQPGERIVTLEVHGKPWSTEQLAAELERWRLDARNVNLMVGGPEGLAPEVCARSEQRWSLSPLTLPHPLVRILLGEQIYRAWTVLSGHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLF1_MOUSE
Sequence: MEDSATKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGKWVLTKDYIIHSAKSGRWLDETTYEWGYKIEKDSHYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRADKRSDSLVRVLEAGKANVILPKNSPSGITHVIASNARISAEREQENFKAPFYPIQYLGDFLLEKEIQNDEHSQISPAWTKYNNQEKGNDVGFPEMKGAGENMYRTQNKMENHNKNVSDRFVLSEHHKKKFKDFRKDIRSVKKRNTLRRHGLENQKETKKKDKNIQRSYILRKKNKKEGYCKTDDAHDTIRSMLKKRGHYREQKEMKNPLLTDGTKESKTKDVKTNMNLIEIKNALKKQIYKDIYRAQAVRYNCIRVDKQPVYNVEVKNSEFPRGILNLIENLIEGQFFKEAIEELSSLQAHYIPPVCLLHAILENVLQDKIDTFSGRYFHILSALLHLHPPWKSPAMLKYYLELFQCPTCMKGAWDFTEVLIRSCLFNEDFCHQISENISTKVVNLTLLKFFFNLLEGEVRHLSQKLCDWSDSQSLKVTEKAILHEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKCKSNDVFKHELSYLLTGILGAAVDYWIFLGIQMGRNVIRHMSDDLGSYISLSCDDFSSKELEIFICSFSSSWLQMFVAEAIFKKLCLQGPTSTCTEPLSLQKIIDSYLPILGKMDIHGAGKMQSPKKLCQRPCLESQRALLMLNGAKRKQAEGRPELLELNRAKCSSSLKKLKKKSEELSCSKENCPSLVTKMNFHKTNLKGETALHRVCIKNQVEKLIILLSLPGIDINVKDNAGWTPLHEACNYGNTECVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQRGGPELLQQRNSKGELPLDYVLSPKDKEELFAITNIDDTVDNFHAKTQKHFYHQQLEFGSFLLSRMLINFCSIFDLSSEFILAFKGLGHLNELLMACNSDTEASNAHTDWLLDVYARNIKTLKKLPSVLKELPENLNVCPGVHTEALLVTLKMMCQSITELS
What is the function of this protein?
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance.  The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks.  Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions.
What are the official names of this protein?
SMC5-SMC6 complex localization factor protein 1, Ankyrin repeat domain-containing protein 32, BRCT domain-containing protein 1, Protein BRCTx.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage (PubMed:22036607). Colocalizes with RAD18 in the nucleus and to centrosomes (PubMed:15632077). Associates with chromatin. Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner.
Protein: PKP2_RAT
Sequence: MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPVARSQRIQEQVQQTLARRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQSPAARDYDMLKVGLSGWRDGSTLKVPCTSIKPHREKKTWIEALREGLEHTTDHTDCPAHYVYSHYYFNSKKSNILVFQHIKDKSLQRNAIILLSPEHCTCQHVRLIPSSVLPSLFNQLQLSPELYFSNMGTLYMTSIKGTLCIQLLKGKLPAKHQANFVTMAERRVYTLLLSSTTSSETSFRRTGDTLPSVTSGQSRVHGLHFHHVICDCLSRNADLEMTLERAVNMLDADHVPLSKISAAATFIQHESFQKSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKVTVVLGKVNITKREGGGQAAGYMKETWKLANKNPVFLGLLWNLSSSDKLKHLMITEALLTLTESVIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRSRKVKEQYQDTPMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLTAGSGPIPTSVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLYSLWAHTELHNAYKKAQFKKTDFVNSRTAKASHSLKD
What is the function of this protein?
Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (By similarity).  Required to maintain gingival epithelial barrier function (By similarity).  Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes (PubMed:19661460).  Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity).  Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity).  Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (PubMed:26858265).  May play a role in junctional plaques (By similarity).
What are the official names of this protein?
Plakophilin-2.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
Protein: ACSA_SHEB9
Sequence: MSSQSLYKVSGNIAANALVNNDKYKTMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTSFDDHNLSINWFYDGTLNASANCLDRHLAEHSDRVAIIWEGDNASEQRKITYGELHAEVCKFANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHSVVFGGFSPDSIASRVIDGKSKVIITSDEGMRGGRAIPLKRNIDDALKNPDVTTVEKVIVLKRTGGIVDWVEDRDVWWHSLMETASEYCQPEEMDAEAPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKAGEVYWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNHPSPARLGEMIDRHKVSILYTAPTLIRALMAEGKQHFDKFDGSSLRIMGSVGEPINPEAWRWYHEVIGHEHCPIVDTWWQTETGGILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGENEGNLVLLDSWPGQMRTVYGDHERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHELVAEAAVVGYPHDIKGQGIYAYVTLTRGTEETEELRQELRQWVRKEIGALATPDLIQWATGLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIETLIESRLNRTE
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: YNEA_LISMC
Sequence: MTMKLIWDKFYVSIIFVLTCIILGIILMCTVVGGGNDYSEVNVSEGDSLWALADQYAGKSDMAKADFVSWVEKENNLADGHVEAGDSVVIPVHKTKLIKSDSTIQLANQ
What is the function of this protein?
Inhibits cell division during the SOS response.  Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC to the division machinery.
What are the official names of this protein?
Cell division suppressor protein YneA.
What is the protein family that this protein belongs to?
Belongs to the YneA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_HALMT
Sequence: MSEAEFHEMRDPRIEKVVVHMGVGEGGRELAKSEDILEEITGQESVRTISGRASQDFGVRQGEPVGAKVTLRGESAVEFLETALPITDLSASSFDETGNFGFGVEEHTEFPSQEYDPQIGIYGLDVTVNIVRPGYRVKKRDKRSRQIPSSHRMTVEDAVAFIESTFDVEVEE
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5, HmeL5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RL1_SACS2
Sequence: MQIVDRSNLEASLKLALSPENNPKRNFVQSVEIIVTFKEVDMKKGDLKLREIVVLPKPPEKTKKVLVVPTIQQLEYAKKAEPNTILTKEELQKLQGNKRAIKKIARQNDWFLIAPDSMALVGRILGPALGPRGKFPTPLPNTADISEYILRFKRSTLVKTKDQPQTQVFIGTESQQIADLAENALAVLNVIESKGYAQKVRNIYVKTTMGKVVKVELR
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: YCF35_TRICV
Sequence: MSHFTNIETRFQNLFYLEKALNKLDINHKPQKKVTNINSKSYDIDINLMISQPNGYDIEFCWNGQEYELIADTSFWQQKDSIKGFINNIAKQYAGEVIIGESKKIGFQPIKYQQNKDGSNTCYFTTLE
What are the official names of this protein?
Uncharacterized protein ycf35.
What is the protein family that this protein belongs to?
Belongs to the ycf35 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL11_PROM5
Sequence: MAKKIVAVIKLALQAGKANPAPPVGPALGQHGVNIMAFCKEYNARTQDKAGFVIPVEISVFEDRSFTFITKTPPASVLITKAAGIEKGSGESSKGSVGNISKSQLEEIAKTKLPDLNCTSIESAMKVIEGTARNMGISITE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.