PharMolix/UniProtQA huggingface dataset:
Protein: MEND_SHEFN
Sequence: MQQQTSADMNLLWGQLILEELARLGVKHVCMAPGSRSTPLTLAAASQTQLTRHIHFDERGLGFMALGLAKASNAPVAIITTSGTAVANLYPAIVEAWLTHVPLIILSGDRPPELIDCGANQAIIQPAIFAQYAKQVNLPTPDLGYPANALLSTIDHALANQHQPVHINCMYREPLYPTELVTLAHVKKTASVTTSTYLAPLNQWFENTKPLTRYASLTSAELPTTDTLMRFVHGKGVIVVGTLAPEDNPQQIVALAQKLGWPVLVDAQSQLRQHPGVIGHVDQLLLNPKANKQLEQAERILVFGGRFISKRLLQYIAQQSWHSYWHVVKHGDRLDPTHQSKEFYQASVQAVCQLPWPRSSQANWALQLLPLNESLESLFKQQIDNTTFGEAQVVRAIALAQSDQHILFIGNSLPIRLYDMYAPIATNTPAIYTNRGASGIDGLIATACGVAADKNAPTTLVMGDLSCLHDFNSLALLKQMTQPFVLVIINNDGGNIFNLLPVPNESLRNDFYRLSHGLEFGYGAAMFGLAYRQADDIESFNQAYQEAFEFNCASVIEVNVSPTQASDQITQISQWVKQH
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: AROD_CLONN
Sequence: MKTVNIRGVILGEGIPKVCTPLVGRSLKELREEINLLKDIDCDLVEFRADFFEHVENIQKVKEVLLEIREALKEKPILFTFRSAKEGGEREVESEFYCKLNKEIIKTKLIDAIDIELFNEEESILELIKIAHDEDVKVVMSNHDFHKTPPKEEMISRLVKMQELGADVTKIAVMPKGSSDVLTLLEATNDMKIKYAKTPFITMSMKGVGMISRISGEVFGSAVTFGASKKASAPGQLQVKELKEILNVVHNVL
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: UPP_SALPK
Sequence: MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MSRA1_CAUVC
Sequence: MLSLHKTLEMPSADTALPGRAAPIPTAQTHFVNGHALKGPYPEGLETAIVAMGCFWGVERVFWKVPGVYVTAAGYAAGITPNPTYEEVCTGRTGHTEVVLVVFDPKVVTYEALLKTFWENHDPTQGMRQGNDIGTQYRSGLYVTSDAQAAAAAESKAAYQQALSARGLGTITTEIAPAGPFYFAEDYHQQYLAKNPNGYCGIGGTGVVCPIGLGVEG
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA 1, Protein-methionine-S-oxide reductase 1, Peptide-methionine (S)-S-oxide reductase 1, Peptide Met(O) reductase 1.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: KV3AK_MOUSE
Sequence: DIVLTQSPASLAVSLGQRATISCRASKSVSAFGYSYMHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAVTYYCQHSRELPPTFGGGTKLEIK
What are the official names of this protein?
Ig kappa chain V-III region PC 7940.
Protein: HEM1_HYDCU
Sequence: MKLLVLGVNHETAPVDIREKVSFSPAQVQNALSELKSQGLANESVILSTCNRTEIYTTLKSQSPEKIRAWLHEYFELEEDSINSFLYEYADIEAIKHMMRVSSGLNSLVLGEPQILGQIKEAFHLAHKSDSVHQTLHALFQYIFKTAKQVRTDTAIGSSPVSVAFSAVALSKQFFGKLENQTALLLGAGETVELVARHLKESHIGNLIIANRTLSKAHQLTESLGGYAISLHEIDDHLHEADIVIASTASPTPILKTEMVANALKKRRNKPMFMIDIAVPRDIEPAIGNFSDTYLYTVDDLQEIIEENKRSRKDAALEAEEIVELQAENFMAQYQATQQISPIIQRYRQQAYTLKEHALQDALHHLENGGDPQELLTKLANQLTNKILHTPTTNLHHAGLNGQKEVIQAAEQILLTQQSDASDSSENENTHATS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: P40_TRVPP
Sequence: MHELLRKWLDDTNVLLLDNGLVVKVRSRVPHIRTYEVIGKLSVFDNSLGDDTLFEGKVENVFVFMFRRFLCVNKDGHCYSRKHDELYYYGRVDLDSVSKVTSGYEKLFIHRELYILTDLIERVSKFFNLAQDVVEASFEYAKVEERLGHVRNVLQLAGGKSTNADLTIKISDDVEQLLGKRGGFLKVVNGILSKNGSDVVTNDNELIHAINQNLVPDKVMSVSNVMKETGFLQFPKFLSKLEGQVPKGTKFLDKHVPDFTWIQALEERVNIRRGESGLQTLLADIVPRNAIAAQKLTMLGYIEYHDYVVIVCQSGVFSDDWATCRMLWAALSSAQLYTYVDASRIGPIVYGWLL
What is the function of this protein?
Involved in transmission of the virus by the vector nematode Paratrichodorus pachydermus.
What are the official names of this protein?
40 kDa protein.
Protein: MT1_DANRE
Sequence: MDPCECAKTGACNCGATCKCTNCQCTTCKKSCCSCCPSGCSKCASGCVCKGNSCGTSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-1, MT-1.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: QUEC_METTP
Sequence: MGRAVCLCSGGLDSTVAATIARRSGMDVYLIHVSYGQQAERREIEAIERIADAIGASDLMCSRIDLFRNISALTTQGARIPRGEEVSLDSESTPPTWVYCRNTVLLSMAAAYAEYLGAHSIYVGFNAEEAMSYPDNRPEFVEQFNALLEKAVASFSRPPKVVAPLVDMRKKDIVRLGADIKAPLELTWSCYLNGEIHCGTCESCQHRRRGFVEAGIPDPTEYQH
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, Archaeosine biosynthesis protein QueC, PreQ(0) synthase.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: CDC14_CAEEL
Sequence: MREDHSPRRNNTIENTLTELLPNRLYFGCFPNPDAIDKSDKSVKKTCFININNKFHYEPFYEDFGPWNLSVLYRLCVQVGKLLEVEEKRSRRVVLFCQDDGTGQYDKIRVNTAYVLGAYLIIYQGFSADDAYLKVSSGETVKFVGFRDASMGSPQYLLHLHDVLRGIEKALKFGWLDFSDFDYEEYEFYERVENGDFNWIIPGKILSFCGPHNESREENGYPYHAPDVYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPGSVIGPQQPYLIEKQKFCWSLSQSNGVHLTQNKEEKRNVRRLVNQVDDINLGEERISPKSRENTRPNILRRRVQVQNGRSTAPVTIAPAGTSESRRSTKPSRVVDETALDDQGRSQGDRLLQLKAKHQHESETTSPNSSSSRRFVKSSTPQMTVPSQAYLNRNREPIIVTPSKNGTSSGTSSRQLKTTPNGNVAYRTRNSSGNTTSTLTRTGNESYRFHNSLFYEPASAVFPSMASRRSETTRYLSPTTPIKPMSPSYTDGTSPRYKARLRSENPIGSTTSTPFSLQPQITKCSLTAESKPPKRILSMPGTSKSTSSLKKIQVSRPRPYPSTGVRVELCANGKSYDIRPRKEAHVIPGAGLAANTEALLGVCKLVNTLS
What is the function of this protein?
Main regulator of cell cycle arrest in vulval precursor cells.
What are the official names of this protein?
Tyrosine-protein phosphatase cdc-14, Cell division cycle-related protein 14.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Nucleus. Note=Localizes to the cytoplasm throughout interphase (PubMed:15247923). As cells enter prophase, accumulates at the centrosomes (PubMed:15247923). During metaphase and anaphase, localizes to the spindle, in particular spindle asters and the spindle mid zone (PubMed:15247923, PubMed:12213836). During late telophase, localizes to cytoplasmic aggregates (PubMed:15247923). In some studies, localizes to the midbody during late telophase (PubMed:12213836). Localizes to the cytoplasm in G1-arrested cells (PubMed:15247923). Localizes to the nucleus or nucleolus in postmitotic cells (PubMed:15247923). Some studies report no localization to centrosomes or nuclei (PubMed:12213836). Co-localizes with zen-4 at the spindle, and localization may be dependent on each other (PubMed:12213836). SUBCELLULAR LOCATION: [Isoform c]: Cytoplasm. Nucleus. Note=Localizes to the cytoplasm during interphase, but localizes to the nucleus during cell cycle arrest.
Protein: Y1059_METJA
Sequence: MSNKKKQLTVMGTVWDFWSVLKMFDKLYESKYISFYEPWLKGEIDKEKIILFNEKSKNPLLWPFKILKRTYKILKIIREFKPDLVITHHDDANVSIIPVILLNKIFKISNNTKFILWVRNNPIESYKEGLYSKIIILAYKYFYKYADIIIVQTQENKKIIESHFKSLKNKTKIVPNVYEIDKLQQLSNEPLEKQYRNIFKDSFVFINIGRLTEQKGQWFLIRSFKRVTEKYPNAKLIILGDGELKNKLQELINKLNLQNNVYLLGMQKNPFKFLKHSNCFVFSSLWEGLPNTVIEALSLNLPVISTDCKTGPREILCPELNISDKIDYPYYGKYGILTKPFSREFIWQDLNEKPLIEEEKMLADLMIKMIEDEDLRKRYSNGLERAKDFDIEKIIKEWKLLIEGTI
What are the official names of this protein?
Uncharacterized glycosyltransferase MJ1059.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: Y452_PYRAB
Sequence: MRKLGLALSIMGLLLVSIVAGCIGGGTETKTEAKKVKVAILFDVGGRGDLSFNDMAYLGAERAKKELGVEIEYMTPKSKEDMKPLLEQLAQSKEYDLLVLVGFLWTSPLNEVADKYPDQKFALIDSTTGKVRENEVDILFREQEAAALMGVIASGMAYELGGDTIGAVAGMDIPPLWKFHIGYLFGAKYFEKKTGKPVKLLWQYTGTFGDTQVGYNTAMQLLQQGAKVLYGLAGLTHVGMFDAVKDWNEQGRGKALAMGQDASQEWYAPKYIPISGAKRVDVAVYDAIKMVVDGTWKGGIITLGLKENGVGYWDLDGVKQFAEFAKEAGKLKDMTPDEVVQIVKEQREKYIKPYVWDIVHELEEKIKSGEIVFKTPKTHEEYEQIIRELEKGNLNAALEKGSVE
What are the official names of this protein?
Uncharacterized lipoprotein PYRAB04520.
What is the protein family that this protein belongs to?
Belongs to the BMP lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: BSHC_BACC3
Sequence: MEIKEISVPQQGVVADYMNGKKEIQSCFDYMLTEDAFKQRVQDLREREFFRQDLVTHLLEYNTKLQAGEATIQNVKALGDENTYVVIAGQQAGLLTGPLYTIHKIISVLQLAKEKEESLGVKVVPVFWIAGEDHDMDEINHTFVTKNKKIKKTIFHDRNPKKASASESELSLEDCRKWIEEIFKTYPETNFTKDVLQFVDDSLRKSNTYVDFFGHLIMKMFVNSGLILVDSHHPELRKLEVPFFKQIVSKYKEVQEGLHNQQEVIKELGYKPIIETKSNAVHIFMEIDNERVLLEDNQGKFVGKDGTYSFSYEELIEEMERSPERFSNNVVTRPLMQEYVFPTLAFIGGPGELAYWSELQQVFHTIGFRMPPVVPRITITYIERDIATDLHDLQLQERDPFLNNVDKLRENWLSNQIEEPIDDRFVEAKKEIMNIHTSLQQFVKEIDPGLSAFAGKNEFKINEQIELLERMLKRNVEKKHEVELNKFRRIQFALRPLGAPQERVWNVCYYLNQFGLDFVDHVMEKTFSWNGKHHVIKL
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: CLPX_THISH
Sequence: MSDNKMKDSDSGKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREEMQEQGAAVGDKLPKPHEIKKILDEYVIGQDRAKKILAVAVYNHYKRLEARNSKDEVELAKSNILLIGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQTGIVYIDEIDKISRKADNPSITRDVSGEGVQQALLKLIEGTIASVPPQGGRKHPQQEFLQVDTHNILFIVGGAFAGLDKVIRDRTEKGGIGFSAKVKSKEEKGPVSRTLSGVEPEDLIKYGLIPEFVGRLPVVATLEELDEDALIQILTEPKNALTKQYGKLFEMEGVDIEFREDALRAVAAKAMERKTGARGLRTILEQVLLDTMYDLPSTENVSKVVIDDAVIRGEAKPYLIYENSDYQKAAASD
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: MRAZ_CHLPM
Sequence: MAGFIGKERHSIDEKGRLMIPARFRRKFADAGSCDGGASEYGRFGALYVMKTSDGSLELYEPSVWEGMGKSISALSDFNPEERLLKTLMYECLEMVELDRQGRIPLSREFLEHAGISGEVVILGADTKMIVWEPARLRGVVDGSSGRFAALAGRYF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PSMG1_HUMAN
Sequence: MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQLARKREVRLLRRQTKTSLEVSLLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAFCVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSESTGSLPSPFLRALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVMKLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT
What is the function of this protein?
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2.  The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
What are the official names of this protein?
Proteasome assembly chaperone 1, PAC-1, Chromosome 21 leucine-rich protein, C21-LRP, Down syndrome critical region protein 2.
What is the protein family that this protein belongs to?
Belongs to the PSMG1 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: RL2_MARMS
Sequence: MAVVKSKPTSAGRRHVVKVTNNDLHKGAPYAPLLDTKSKSGGRNNNGRITTRHVGGGHKQHYRMVDFRRNKDGISAVVERLEYDPNRSANIALIRYADGERRYIIASKGMVAGNIVFSGADAPIKAGNTLPLQNIPVGSTVHCVELKPGKGAQVARSAGASAQLVAREGRYVTLRLRSGEMRKVLTECRATLGEVSNSEHSLRVLGKAGATRWRGVRPTVRGAAMNPVDHPHGGGEGRSKGGRHPVTPWGVPTKGYKTRSNKRTDKLIVRRRTK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: TRUA_ANAMM
Sequence: MRYRAVVEYDGTAFIGWQRQKGVAGRSVQESIEDAIYRLSQQCVTVFAAGRTDAGVHALGQVVHFDLNTSLQDYVIKNALNHYLRSDMVSILSLEEAAEGFHARFSAKKRHYMYKIVNRDAPPCLDRLRMWHVPKQLNVSDMQEAASHMVGEKKDFASFRAKECQSKSSVRTVDRIDCVREGNNIFVHVSAKSFLHKQVRIIVGTLVQCGHGAFPPSYVLEILERKNRAAAGITAPPHGLYLVLVEY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: RL39_THEON
Sequence: MARNKPLAKKLRLAKAAKQNRRVPVWVIVKTNRKVMTHPKRRMWRRTKLKE
What are the official names of this protein?
50S ribosomal protein L39e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: LEU3_PSYCK
Sequence: MATILTLAGDGIGPEIMTQAIDVLNAVNDKFALGLTLESGLIGGVAVDSTGEPLPEETLQRARAADAVLLGAVGGPKWDGIERSKRPERGLLKIRSELGLFANLRVAKLYPQLVNASSIKPEIISGLDLLIVRELTGGIYFGEPRGIRTLENGEQQGYNTMVYSTSEINRIGKVAFELAQTRAQAAGTAAKVCSIDKANVLEVTELWKQTMIELQQSEYSDVALSHMYADNACMQLIKDPKQFDVMVTGNLFGDILSDEAAMLTGSIGMLPSASLDEAGKGMYEPCHGSAPDIAGQDIANPLATILSVSMMLRYTFKQEAAAQAIEQAVSDVLDDGLRTVDILDRNEAGLIQVGCQQMGQAVLAKLI
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYS_RUDPH
Sequence: METVSVEEGLDFAPGMVSQKCLLCMCKLESGGCKPIGCRMDVGSLSCGYFQIKQPYWIDCGKPGKDWKSCSNDINCSSKCVQQYMKRYATHYRCPLNCEGFAREHNGGPNGCHSSRTLKYWELLQKIPGCKGVKFS
What is the function of this protein?
Bacteriolytic activity against Gram-positive bacterium M. luteus and thereby probably protects against bacterial infection (PubMed:9914527, PubMed:14523554, PubMed:15249048).  Also has chitinase activity (PubMed:15249048, PubMed:9914527, PubMed:17631496, PubMed:14523554).  May act as an ispopeptidase, cleaving isopeptide bonds between the side chains of Lys and Gln residues in proteins or in the cross-linking peptide of peptidoglycan in bacterial cell walls (PubMed:15249048, PubMed:14523554).
What are the official names of this protein?
Invertebrate-type lysozyme, 1,4-beta-N-acetylmuramidase, Destabilase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FGFR4_MOUSE
Sequence: MWLLLALLSIFQGTPALSLEASEEMEQEPCLAPILEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLLMDDSLTSISNDEDPKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPEARYTDIILYVSGSLVLLVLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPFSPSNGDASSTCSSSDSVFSHDPLPLEPSPFPFSDSQTT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.  Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.  Phosphorylates PLCG1 and FRS2.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation.  FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4.  Plays a role in postnatal lung development.  May be involved in the development of skeletal muscle cell lineages.
What are the official names of this protein?
Fibroblast growth factor receptor 4, FGFR-4, Protein-tyrosine kinase receptor MPK-11.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
Protein: PCOC1_MOUSE
Sequence: MLPAALTSFLGPFLLAWVLPLARGQTPNYTRPVFLCGGDVTGESGYVASEGFPNLYPPNKKCIWTITVPEGQTVSLSFRVFDMELHPSCRYDALEVFAGSGTSGQRLGRFCGTFRPAPVVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRMEKAQGTLTTPNWPESDYPPGISCSWHIIAPSNQVIMLTFGKFDVEPDTYCRYDSVSVFNGAVSDDSKRLGKFCGDKAPSPISSEGNELLVQFVSDLSVTADGFSASYRTLPRDAVEKESALSPGEDVQRGPQSRSDPKTGTGPKVKPPTKPKSQPAETPEASPATQATPVAPAAPSITCPKQYKRSGTLQSNFCSSSLVVTGTVKTMVRGPGEGLTVTVSLLGVYKTGGLDLPSPPSGTSLKLYVPCRQMPPMKKGASYLLMGQVEENRGPILPPESFVVLYRSNQDQILNNLSKRKCPSQPRTAA
What is the function of this protein?
Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
What are the official names of this protein?
Procollagen C-endopeptidase enhancer 1, P14, Procollagen COOH-terminal proteinase enhancer 1, PCPE-1, Procollagen C-proteinase enhancer 1, Type 1 procollagen C-proteinase enhancer protein, Type I procollagen COOH-terminal proteinase enhancer.
What are the subcellular locations of this protein?
Secreted.
Protein: SAHS1_RAMVA
Sequence: MSRAAVAIALLGCVVAAYGAPAEGHDDAKAEWTGKSWMGKWESTDRIENFDAFISALGLPLEQYGGNHKTFHKIWKEGDHYHHQISVPDKNYKNDVNFKLNEEGTTQHNNTEIKYKYTEDGGNLKAEVHVPSRNKVIHDEYKVNGDELEKTYKVGDVTAKRWYKKSSSS
What is the function of this protein?
Secreted heat soluble protein acting as a molecular shield in water-deficient condition (PubMed:22937162).  Tardigrade-specific intrinsically disordered proteins (TDPs) are essential for desiccation tolerance by forming non-crystalline amorphous solids upon desiccation, and this vitrified state mirrors their protective capabilities (By similarity).
What are the official names of this protein?
Secretory-abundant heat soluble protein 1, SAHS1, Tardigrade-specific intrinsically disordered protein SAHS1, TDP SAHS1.
What is the protein family that this protein belongs to?
Belongs to the Secretory-abundant heat soluble protein (SAHS) family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y022_SIFVH
Sequence: MTQNINKIYLPSPNKYLSREDFLNYTNLMREIANFDPSTKKWYINEYKISRLTKDELKGIIDQIAEYIGNSIYNILSNYIKDDNNIINAYIKGNYIYIRDNLEKYKNLLTYKIKTFDYKEGKYTEEEILLAWQKSYGFVTLRGLYWKLKNIANFDLKPFTNLRFYDIQLKNFEMRNYQINSIKSWVSDVNVIGNGIIKAPTGSGKSVIAILSALEILKNKNNAKIVYAVNSTTLLKQFQNFAKKEDLPFVLVSGEIDEIKKGERSDFIALSISYYYSKKKRNEHEKLKELVTNADLVIIDEAHHTPANIVKSLLLDSPNSIRLGLSATPIREDGKELEIMGLLGKISFTIDYTELVRNRYLVPIEYIRYIPEIPKKLKLKIQDLDDNKDPENFAKYYSSLLRSFEHSPNTNKQIISKIKQLNQYPCLVIVRRIAIAKKLAEIMRENGIIADWVSSKTKLEERMEKIEALKNEKLQVLISTSLADEGLDIPNLRLVVLLTQGKSRIKLIQRIGRVMRVSQNKRKGYILDVIYNHDLFIKQSVKKMNFIENEYNGIITIHY
What are the official names of this protein?
Putative helicase 22.
Protein: ADDB_MOUSE
Sequence: MSEDTVPEAASPPPSQGQHYFDRFSEDDPEYLRLRNRAADLRQDFNLMEQKKRVTMILQSPSFREELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHAVFPASSMNFSMMTPINDLHTADSLNLAKGERLMRCKISSVYRLLDLYGWAQLSDTYVTLRVSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSSCFPVDTTGFSLHSAIYAARPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLVGDMAYYDFNGEMEQEADRINLQKCLGPTCKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALSSAGGTENLILLEQEKHRPHEVGSVQWAGSTFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYRHPFVQEKTKHKSEVEIPATVTAFVFEEDGVPVPALRQHAQKQQKEKTRWLNTPNTYLRVNVADEVQRNMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLDMRNKIREQNRQDIKSAGPQSQLLASVIAEKSRSPSTESQLMSKGDADTKDESEETVPNPFSQLTDQELEEYKKEVERKKLEQEQEGEKDIATEKPGSPVKSTPASPVQSPSKAGTKSPAVSPSKTSEDTKKTEVSEANTEPEPVKPEGLVVNGKEEEPSVEEALSKGLGQMTTNADTDGDSYKDKTESVTSGPLSPEGSPSKSPSKKKKKFRTPSFLKKSKKKEKVES
What is the function of this protein?
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network.  Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane.  Binds to calmodulin.  Calmodulin binds preferentially to the beta subunit (By similarity).
What are the official names of this protein?
Beta-adducin, Add97, Erythrocyte adducin subunit beta.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. Adducin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.