PharMolix/UniProtQA huggingface dataset:
Protein: RL331_SORC5
Sequence: MGEQAGGWRAARIAVSLACRECKSRNYKTTKAPDQVVSLKKFCKQCKKHTVHDETK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: HBB_PTEBR
Sequence: VHLTGEEKAAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFDSFGDLSSPDAVMGNPKVKAHGKKVLNSFSEGLKNLDNLKGTFAKLSELHCDKLHVDPENFKLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RS17E_SULIN
Sequence: MGNIYTKDIKRIVKEIYNQYKDEIKDDYNTNKQIVVRYVDVKSKKVRNRIAGYLTRYYKIMKEKETSPTEEKEEISEEI
What are the official names of this protein?
30S ribosomal protein S17e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: PB2_I80AD
Sequence: MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIMEMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSTAHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQNCKIAPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMIGILPDMTPNTEMSLRGIRISKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWEMIKIQWSQEPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGSLTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: DLL4_MOUSE
Sequence: MTPASRSACRWALLLLAVLWPQQRAAGSGIFQLRLQEFVNQRGMLANGQSCEPGCRTFFRICLKHFQATFSEGPCTFGNVSTPVLGTNSFVVRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKIWRTDEQNDTLTRLSYSYRVICSDNYYGESCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECICRPGWQGRLCNECIPHNGCRHGTCSIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPKGYTCTCLPGYTGEHCELGLSKCASNPCRNGGSCKDQENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGSSYACECPPNFTGSNCEKKVDRCTSNPCANGGQCQNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITHDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVVVAVRQLRLRRPDDESREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGLLGRGGMPGKYPHSDKSLGEKVPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV
What is the function of this protein?
Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954).  Activates NOTCH1 and NOTCH4.  Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity).  Essential for retinal progenitor proliferation.  Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (PubMed:22323600).  During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity).
What are the official names of this protein?
Delta-like protein 4, Drosophila Delta homolog 4, Delta4.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GEI17_CAEEL
Sequence: MLPNNQWQIPINNGLTHQENMAAHAAVMKLRVHDLQSIISQLSLRKPRPQKSEHQKVVVESLRDPHHARQIYQMASNFPNGNYEMQKRPATTSQVRSHPYVLPSRSGASNHLVNHHYQQQQQQQPQPHNLLHQQMMASHHSHLQQQHHPSTVRWLTPELLEEQLRGSMRYGAPAAAAATNAPLHSSFPNHGRSSQQSLQKSEKSNRPKKMYADNFEPLPLPFYDVISVLLKPVELHSSDSPTLKQTKQLQFPFLLTAEHISKISYRADVTPLPRYELQLRFFNLTEPVQGPQKDDFPLNCYARVDDSVVQLPNVIPTNKTNAEPKRPSRPVNITSNMNRYKKEHTVAVEWLADKRVWAAGVYFVHRVNSDILFKRLNQNVSRHRSLEVTKQEVIKKLSGGEDDIAMDRLNISLLDPLCKTRMTTPSRCQDCTHLQCFDLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLAKVDKNTTEVELKEDGSYDVIKEEAFCISDDDDDDVVPATVNGTASCSSTNGNGLANEAAKKKPADDDIITLSDDDDEELNRGIMNSLNDSFSPGRHTASAELAAQKTPPQQKKKTKDDDIEIITLDDTPPRPVAASANLPMRQMSQQNQMPVGSSPSGMASTQMGMNEGASKTIRDALNKIGEQSANSSTQSSPLVQLHHTTHPLNFAQSSYMNPSSGSQTPTSQYGYSPMINQAPHFQMQNGLIGRNNQMVHMQQHHLQQQQQQQQSPQIMSPSFYAQQQMSNGGAFAYYPPQYPQQQYRQN
What is the function of this protein?
Functions as an E3-type smo-1 ligase (PubMed:15654100, PubMed:16701625, PubMed:16549501, PubMed:25475837).  Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment (PubMed:25475837).  In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation (PubMed:15654100).  In embryos, plays a role in determining telomere localization in the nucleus (PubMed:24297748).
What are the official names of this protein?
E3 SUMO-protein ligase gei-17, E3 SUMO-protein transferase gei-17, Gex-3-interacting protein 17.
What is the protein family that this protein belongs to?
Belongs to the PIAS family.
Protein: TBP_TETTH
Sequence: MSSDKTSQQTFKLAPNNSVAQSNSIDQNKNKNNILSTIETMDKSISEDLYPKLQNIVSTVNLSTKLDLKQIALRARNAEYNPKRFAAVIMRLRDPKTTALIFASGKMVCTGAKTEEDSNRAARKYAKIIQKIGFPVQFKDFKIQNIVGSTDVKFPINLDHLEQDHKKFVQYEPEIFPGKIYREFNTKIVLLIFVSGKIVLTGAKTRENINKAFQKIYWVLYNYQKKDYRGANLHNQNLNIKPSIKN
What is the function of this protein?
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID.  Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
What are the official names of this protein?
TATA-box-binding protein, TATA sequence-binding protein, TBP, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit.
What is the protein family that this protein belongs to?
Belongs to the TBP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ADD_YERE8
Sequence: MIDPRLPLTDIHRHLDGNIRAQTILDLGRQFNLSLPADELEALRPHVQITKTEPDLVSFLQKLDWGVAVLGSLEACRRVAYENVEDAANAGLHYAELRFSPFYMAMKHQLPVAGVVEAVIDGIQSGCRDFDIDIRLIGILSRTFGEQACLQELDGLLAHRDAITALDLAGDELGFPGGLFRSHFNRARDAGWRITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDIKLMDYLAEHNIGIESCLTSNIQTSTVASLAAHPLATFLRHGVLASINTDDPAVQGIEIANEYHIAAPAAGLTPQEIRQAQENGLTMAFISEQEKQVLRDKIRN
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: CUL4_CAEEL
Sequence: MTSGAPPTISTEKSRSKQLRKSSKRTASTVEGTEAKQMRGDTENRSDGEMDDVSTSSEIRHGNGFIENFRSQTGNSSRTTATNERIKKKLVIKNFKANANQNDVAMGDTNIDSTDGSVGRDWAVLSDNVFAILEDRKTVTTLEGLFSKVRSVCDKNQSKVLYDRLVAIVVQFAKSLKESLNAVEQVPLAEDNCEQYLEKFGQIWQAYPVKINLIRNIFLHLDRIALGATDTEILPLWECFMQIFQKTFFPNIFKEFKATKLFNALYMAMQKIMQRYPVDSPLRSLVDMLQTVHVSEEFAKFLISQLREHYNNERIDKVPKMNCNDYMEYCEDQINRYSQLVKVNFDEPSALKDVQATVTNCLIQQAIPEILTHDFDDLIDSDNISDIGRMFNLCRQCVGGEDEVRTQFSKYLKKRGEKLIATCPDEDLVSELLAFKKKVDFIMTGSFKSANDPVKMRQCLSDAFESFVNKQVDRSAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRYLRGKDVFEAYYKRGLAKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRLFNQYLEHMNKEKANFTARVITPEYWPTYDTYEINIPKEMRDTLTDYQDFYRVQHGNRNVKWHHGLASAVISASFRPGCKKELIATMYQTVILLLFNKCETWTVAEIVEHTKILEIEVVKNVLALLGGRDKPKVLQRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKRCRVRIAQVNIKTAVEETKEVKEEVNSDRQYKIDAAVVRIMKARKQLNHQTLMTELLQQLRFPVSTADIKKRLESLIEREYISRDPEEASSYNYVA
What is the function of this protein?
Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component.  In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication.  Probably is involved in ubiquitination of cki-1.
What are the official names of this protein?
Cullin-4, CUL-4.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
Protein: FADR_ECOL5
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR
What is the function of this protein?
Multifunctional regulator of fatty acid metabolism.
What are the official names of this protein?
Fatty acid metabolism regulator protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 422L_IIV6
Sequence: MSAIFKIIHETSSKFMDSILREGKLLTSNNLNKKFLTDSPKGQGSKDRKLCDSEESIKNKEHFWKHCDEADGVYFRILEMDTPLKTYAGDIILVFSKDMLYKYSWILNTTENFGFYISSPGFEGESQFSGEIGTTYTLDTLKDMDVSSFDPYSSELCVFNNVSLKFLKEIYVREPAFEDLQLSVRALNKYSNAPVIIF
What are the official names of this protein?
Uncharacterized protein 422L.
Protein: AROE_ECOLU
Sequence: METYAVFGNPIAHSKSPFIHQQFAQQLNIEHPYGRVLAPINDFINTLNAFFSAGGKGANVTVPFKEEAFARADELTERAALAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLSFIRPGLRILLIGAGGASRGVLLPLLSLDCAVTITNRTVSRAEELTKLFAHTGSIQALGMDELEGHEFDLIINATSSGISGDIPAIPSSLIHPGIYCYDMFYQKGKTPFLAWCEQRGSKRNADGLGMLVAQAAHAFLLWHGVLPDVEPVIKLLQQELSA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: RPOB_COXBN
Sequence: MAQANSRSRNSATISYPEKRRARVNLGKREVEILKTPYLLETQIESYRKFLQKDIAAEKREDNGLHAAFKSVFPITSYSGYAVLEYVGYSLGGESTLFDVEECKLRGLTYAAPLKVNMRLVIYDKEAPAGKKAIKDIKEQEVYMGEIPLMTETGSLVINGTERVVVSQLHRSPGVFFEHDKGKTHSSGKLLYSARVIPYRGSWLDFEFDPKDCLFVRIDRRRKLPATVILRALGYDTEQILDMFYKTNHFHLNQETVTLDLIPQRLRGELAVVEIKDKKGKVIVEANRRISARHIRLIEKAEINKLELPDDYLYGKVIGKTIIDKETGEIIAHANEEITAELLKNLRATKTASLDTLYINEIECGLYVSDTLRLDTTTNQLEALVEIYRIMRPGEPPTKEAAESLFENLFFSPERYSLSAVGRMKFNRRVGRKELTGLDVLSKEDIVDVLRVLVDIRDGKGDVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKDRLSLADVENLMPQDLVNAKPVSAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHVTHYGRVCPIETPEGPNIGLINSLAVFARANEYGFLETPYRKVVDRVVTDETEYLSAIEEGDYYIAQANTNVDEKGRLVDDLISCRYKGEFTLTTPDKINYMDVSPRQIVSVAAALIPFLEHDDANRALMGSNMQRQAVPTIRPETPLVGTGMERTVAVDSGVTVIAKRSGVIDSVDASRIVVRVDRKETEDDDDIGVDIYNLTKFTRSNQNTCINQHPIVEVGDKVQKGDVLADGPSTDIGELALGQNLLVAFMPWNGYNFEDSILISERLVEEDRFTTIHIQEFTCVARDTKLGPEEITSDIPNVGESALAKLDESGIVHIGAEVNAGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVTPGITGTVIGVRIFTREGVKKDERTLEIEKAELSKVEKDLNDELRVREDALFENLEKLLTGRVAAGGPNKLAKGTKITKSYLADLPRQKWFEIRLQDDAATKRLEASHEHFKELRETRDAKLKDSRQKLTQGGDLAPGVIKIVKVYLAVKRRIQPGDKMAGRHGNKGVISTIVPIEDMPYLEDGTPVDIVLNPLGVPSRMNIGQVLETHLGWATKGLGKKIGEMIEKGADAKELRKSLKPIYDLSKTQRFDLEALEDPEIVTLAKNLRKGVPISSPVFDGATEEEIKQLLKMADLPTSGQAALYDGRTGKKFDRSVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTRMYKNIVDGDHRMDAGMPESFNVLVKEIRSLAIDIGLEND
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: IF2_CALS4
Sequence: MEVNNMSKTRVYELAKELNISSKDLLSKLSDLDIKVKNHMSTLEDEEVELIKDLLAEKPKEEKQKDQKNHEQEAQDKEEKEIEEDSFYEDREEKRAYKKSFKKGGKKNKKLQKKFVSEESAKEDEIKIITIPEFLTVKELAEKMKVNPTEIIKKLIAQGIMVTVNQQIDFETASKIAEEYGFLVDKEEVKDELEAIFEDTPDREEDLKPRPPIVTVMGHVDHGKTSLLDAIRKTNVTMKEMGGITQHIGASVVEINDKKVVFLDTPGHEAFTAMRARGASVTDIVVLVVAADDGVMPQTIEAINHVKAANVPLIVAINKIDLPTANPDRVKTELSELGLVPEEWGGNTICVPVSAKKNIGIDDLLEMILLVAEMEDLKANPNKPARGTVIEAKLEKGKGPVATVIVQNGTLQVGDAVIAGTTYGKVRAMFDDKGRKIKKAGPSMPVEILGFSEVPEAGDKFVVVENEKKARELAEKRREVQRELELKKKQKVSLEDLFRQIQEGTVKELNVIIKADVQGSVEALRKSLEELSNEEVRIRVIHGAVGAITETDVMLASASNAIIIGFNVRPETNAKALAEKEKVEIKLYRIIYDAIEDVKAAMKGMLEPKYKEVELGRAEVRAVFKIPGVGNVAGCYVLNGKIARNADVRIVRDGIVIYEGKIASLKRFKDDVREVQQGFECGIGIEKFNDIKEGDIIEAYTMEEIPR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_MYCBO
Sequence: MLLAIDVRNTHTVVGLLSGMKEHAKVVQQWRIRTESEVTADELALTIDGLIGEDSERLTGTAALSTVPSVLHEVRIMLDQYWPSVPHVLIEPGVRTGIPLLVDNPKEVGADRIVNCLAAYDRFRKAAIVVDFGSSICVDVVSAKGEFLGGAIAPGVQVSSDAAAARSAALRRVELARPRSVVGKNTVECMQAGAVFGFAGLVDGLVGRIREDVSGFSVDHDVAIVATGHTAPLLLPELHTVDHYDQHLTLQGLRLVFERNLEVQRGRLKTAR
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANP3_MYOSC
Sequence: MNAPARAAAKTAADALAAAKKTAADAAAAAAAA
What is the function of this protein?
Antifreeze proteins lower the blood freezing point.
What are the official names of this protein?
Ice-structuring protein SS-3, ISP SS-3, Antifreeze peptide SS-3.
What is the protein family that this protein belongs to?
Belongs to the type-I AFP family.
Protein: PYRE_ECOLI
Sequence: MKPYQRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQGRVMLVDDVITAGTAIRESMEIIQANGATLAGVLISLDRQERGRGEISAIQEVERDYNCKVISIITLKDLIAYLEEKPEMAEHLAAVKAYREEFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: TMM65_HUMAN
Sequence: MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPPGGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKS
What is the function of this protein?
May play an important role in cardiac development and function.  May regulate cardiac conduction and the function of the gap junction protein GJA1.  May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity).  May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance (PubMed:28295037).
What are the official names of this protein?
Transmembrane protein 65.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein. Note=Localizes at the intercalated disk in the ventricular tissue (PubMed:26403541).
Protein: Y4757_DICDI
Sequence: MSHSANFVNVQSPPSYIQLAQQQQQQQQQQLQQQQQTQNPTSPTSFLAQQQYSGNIPTTASNQQPYQHIPQPYQPNISSILQPLPIRYIYVNQLPLAQQQQQLQQNQLQQQPPNVIYQQQPLIVQQQQQPNTVQQQQQQPPQTIQQQPNMAQPQPQQTQQFTMEQTFQNILNKIKDKFDKFTTNHVGQDNITFNNAQLPIAKECNTILLKLQNNRNIHTSSLPFTLTPEVYKPPEFFTKVDIIQYHLSGLASILVLMKLSQVDPSFAKQINLMTVKSKFMIEMLAKIFQQQLDNRNNNNNNNTMSMSITNSTVLSSQKNNNPIIIYFNQQFENIKQLKDYFETSDISSNGLVFFTQTLFSMLTGRGYFWYIGEEVTKQLKYKIFETIYDNLFRTVMKCTSETKYKYNLGCFCYSYFKIIQSDHQVTSARFVTQKPQIKDDLYKYLLHYLSLSNDQLSRALSDVPISDSTIWLIYAKTCCLLNQEEKAQIWIQYFINEATDRVTAAAMIQLDEDIAHYHSKSWYVDIMKSIEEEKKKRIEEDDRLNKQRKQQQQQQQSNSSSPHIVGGHVQDQYSEIKTNLLLEGLVLKNMNHDASLISSNVLLNLHPLPQSKEVQIAQQRLNERLELYMLKNSKEIPGDGNCQMHALSDQLYGDLSHSQEVRKTIVDWLRKNKDFQLPNGATICQFVNTNNWDDYCNDMSKNGNWGDHLTLLAAAEHFGSKISIISSVESQSNFFIEIIPSKILNDKVLLLSHYAEFHYGSLCPLR
What are the official names of this protein?
OTU domain-containing protein DDB_G0284757.
Protein: RL14_STAAE
Sequence: MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVKNATPGGVVKKGDVVKAVIVRTKSGVRRNDGSYIKFDENACVIIRDDKGPRGTRIFGPVARELREGNFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: NACA_CAEEL
Sequence: MTGSTETRQKEVKEPQVDVSDDSDNEAVEQELTEEQRRVAEAAGLGDHIDKQAKQSRSEKKARKLFSKLGLKQVTGVSRVCIRKSKNILFVINKPDVFKSPGSDTYIIFGEAKIEDLTQHAQMSAIENLKPTREAPQLKTVEEDENEDVEEDSTGIEEKDIELVISQANTTRNKAIRALKEADNDIVNAIMSLTM
What is the function of this protein?
May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) (By similarity).  Plays a role in the response to heat stress (PubMed:22957041).
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC, Inhibitor of cell death 2.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAC_YERE8
Sequence: MSRNENRAALSDVLQALQQEEVIAYPTEAVFGLGCDPDSEKAVNALLALKQRPWQKGLILIAANYEQLKPYVDDSALTDSQRETIFSVWPGPVTWVIPTHPETPRWLTGSFDSLAVRVSDHPLVQQLCSQYGKPLVSTSANLSGQEPCRTIEEVRIQFGSSLPVLAGLVGGRLNPSEIRDALTGKQFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UB2D1_HUMAN
Sequence: MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338).  In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).  Mediates the selective degradation of short-lived and abnormal proteins.  Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.  Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941).  Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044).  Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044).  Essential for viral activation of IRF3 (PubMed:19854139).  Mediates polyubiquitination of CYP3A4 (PubMed:19103148).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 D1, (E3-independent) E2 ubiquitin-conjugating enzyme D1, E2 ubiquitin-conjugating enzyme D1, Stimulator of Fe transport, SFT, UBC4/5 homolog, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2(17)KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_SALCH
Sequence: MGSNYIVIEGLEGAGKTTARDVVVETLEQLGIRNMIFTREPGGTQLAEKLRSLVLDIRSVGDEVITDKAEVLMFYAARVQLVETVIKPALAQGIWVIGDRHDLSTQAYQGGGRGIDQTMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGDLDRIEQESFDFFNRTRARYLELAAQDSRIRTIDATQPLDAVMRDIRATVTKWVQEQAA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: MPI_DICDI
Sequence: MENNNNNNNNNNNNNNNNNNIVLLKCVSQNYEWGKYGSNSTVAKLLKGYAKECSDIIKETIPYAELWMGDHVSAPSKVEYKNKELKLREYIDTVQKEINEKSSTSSSSSSSIRGEIVEKRFGNDFPFLFKVLSIRTALSIQAHPDSQLAQVLFKKYPNIYKDPYHKPEIAIATTPFEALCSFRPLSEIQSFIDTIPEFKNSLPNNLIKLDDCKEYLKSIVTSLLKADGLLISNNLKELNNRLNEKREEERDDLDRLVLKLYSQYPGDVGVFFAYILNYIVLKPGEALFLGAGEPHAYISGDCVECMAPSDNVVRAGLTPKLKDVDTLGDMLTYRTGRPDLVVPQQRPDLSLTNYRCYQPPVDEFQVEYYHLDDCCKNINVYSSKGPSIVLVYSGNLSIENKSNQSTLNNLHTGSILFVPANTDYQFIQSDSSIPVSIYVASVSNRIFNKNNL
What is the function of this protein?
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
What are the official names of this protein?
Probable mannose-6-phosphate isomerase, Phosphohexomutase, Phosphomannose isomerase, PMI.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRI62_HUMAN
Sequence: MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
What is the function of this protein?
E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816).  E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM62, Tripartite motif-containing protein 62.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOBB_BACSU
Sequence: MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTIYRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV
What are the official names of this protein?
Uncharacterized protein YobB.