PharMolix/UniProtQA huggingface dataset:
Protein: PRGR_SAPAP
Sequence: MTELKAKGLRAPHVAGSPSSPKVGSPLPCRQATGQFPGSQTSDTLPEVSALPISLDGLLFPRICQAQDPPDEKTQDQQSLSDVEGAYSRVEATRGAGGSSSRPPEKDSGLLDSVLDTLWAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGGKAGDSSGMAAAHKVLPRGLSPSRQLLLPTSGSPHWSGAPVKPSPQPAAVEVEEEDGSESEDSAGLLLKGKPRALGGAAAGGGAPAVTPGTAAGGIALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVTDFIHVPILPLSHALLAARTRQLLEDESYDGGSGAASAFAPPRSSPSASSTPVPGSDFPDCAYAPDAEPKDDVYPLYGDFQPPALKIKEEEEGAEASTRSPRSYLVAGASPTTFPDFPLGPPPPLPPRAPPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAQPQQGPFAPPPCKAPGAGGCLLPRDSLPSTSASAGATAAGAAPALYPALGLNGLPQLGYQAAVIKEGLPQVYPPYLNYLRPDSETSQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDAVALPQPVGIPNENQALSQRFTFSPSQDIQLIPPLINLLLSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
What is the function of this protein?
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Transcriptional activator of several progesteron-dependent promoters in a variety of cell types.  Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
What are the official names of this protein?
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity).
Protein: HIS7_MARMS
Sequence: MADRIASVERNTLETQIKVSINLDGTGKFNCVTGVPFLDHMLEQVARHGLIDLDIHAVGDLHIDAHHTVEDLGITLGQAFDIAVGDKKGIKRYGHAYVPLDEALSRVVIDFSGRPGLEMHVPFARASVGGFDVDLFSEFFHGFINHAKVTLHLDNLRGKNTHHQAETIFKAFGRALRMALEADERMAGQMPSTKGSL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y6509_BACAN
Sequence: MKMKVATAEAKKVNRKRQIESEKSNGKQSFISTIFASFKNTDASIVDIAPYKRLEQKTGILVDHRNNLQVYLKVKTTDLLSMNQDDLKRFMNQLTSLCRVYHEPFKILSLTYSTETTEQQVYWKRMALRFQGRMSQEVSEKKEEHLWYQRYSLAIENLNRVLWVEKNLKELAFFIVVYGKNETELIKNVKDMKRYGGRQFNLQNMKAKEVEKLIFKLQNMNSEM
What are the official names of this protein?
Uncharacterized protein pXO2-10/BXB0009/GBAA_pXO2_0009.
Protein: YEGS_CHRSD
Sequence: MNETIQPCEHDGDTWLILNGKSAQLPEVREAVGRVREAGHHLAVRVTWEGGDGVRLAREASEAGIARVIAGGGDGTVNEIVGGLMQLASETRPALGILPLGSANDFAGGLGLPEEPYEALRVALETPPRRVDVGTLGDDYFINLASGGFGAQITNSTPAPLKRLLGGGAYSLMGMLKAWNYQPYQGRLRFPDGERNVPLFLLALGNGCQAGGGQQLAPLAKIDDGLLELLIVRHFTSLREMKQLIDELENLPESGDFVEYLQVPWVEFESEHALPLNLDGEPCFHENFRAALMPGALCLAAPEGSALLSHQ
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS-like.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_SULIK
Sequence: MSFPKELEKVLEITKAQNVWRRTQTLNLIASENVMSPLAESVYMSDFMSRYAEGKPYKRYYQGTKYTDEIETLAMDLMNEITNSKDCDLRPTSGTIANAAVFRVLAEPGDKALIAPVQAGAHVSHTKFGTLGALGIQHIEMPFDEQNINVDVDKAIKMIEEVKPKFVVLGGSLYLFPHPTKELAPHVHAVGAKLVYDAAHVYGLIEGKVWSSPLKEGADIMTVSTHKTFPGPQGGAIFSDGSEVFKQVSRTIFPWFVSNHHLHRLPATAVTAIEMKYFGESYANQITRNSKALAEALAERGFKVIGENLGYTKSHQVAVDVRQFGGGNKIAKLLEDANIIVNKNLLPYDKPENVSDPSGLRIGVQEMTRYGMKESEMEEIAELFKKVIIDKKDVNKVKKEVIDMRKNFLEVKYTFDDMKDLEKYSSKSLKLII
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLAH_ECO8A
Sequence: MNALTAVHNNAVDSGQDYSGFTLIPSAQSPRLLELTFTEQTTKQFLEQVAEWPVQALEYKSFLRFRVGKILDDLCANQLQPLLLKTLLNRAEGALLINAVGIDDVAQADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSLLLHLDDWEHLDHYFRHPLARRPMRFAAPPSKNVSKDVFHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSELSDAIETSKGILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYFAYATHHYQTHQ
What is the function of this protein?
Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG).  Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Glutarate 2-hydroxylase, G-2-H.
What is the protein family that this protein belongs to?
Belongs to the glutarate hydroxylase family.
Protein: MANF_MOUSE
Sequence: MWATRGLAVALALSVLPDSRALRPGDCEVCISYLGRFYQDLKDRDVTFSPATIEEELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGEMCKGCAEKSDYIRKINELMPKYAPKAASARTDL
What is the function of this protein?
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain.  Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra.  Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons.  Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.  Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions.  Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia.  Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells.  Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
What are the official names of this protein?
Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET.
What is the protein family that this protein belongs to?
Belongs to the ARMET family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen. Note=Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia.
Protein: RHOA_CANLF
Sequence: MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPTEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLVL
What is the function of this protein?
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.  Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle.  Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.  Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis.  Plays an essential role in cleavage furrow formation.  Required for the apical junction formation of keratinocyte cell-cell adhesion.  Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.  The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex.  It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity.  In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.  Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis.  Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center.  May be an activator of PLCE1.  In neurons, involved in the inhibition of the initial spine growth.  Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling.  Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets.
What are the official names of this protein?
Transforming protein RhoA, Rho1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex. Midbody. Cell projection, lamellipodium. Cell projection, dendrite. Nucleus. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner.
Protein: UPP_SHEFN
Sequence: MKVVEVKHPLVRHKVGLMREADISTKRFRELATEVGSLLTYEATADFETETVTIEGWNGPVTIEQLKGKKVTVVPILRAGLGMMDGVLEHLPSARISVVGIYRDEETLQPVPYFEKIVSNVDERIALVVDPMLATGGSMIATIDLLKKRGCTSIKALVLVAAPEGIKALELAHPDIELYTASIDDCLNEQGYILPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MURD_BURTA
Sequence: MFGDRQRPMVLVLGLGESGLAIARWCARHGCRLRIADTRETPPNLAALTAAGIDAEFVGGAFSPALIDGGIELVALSPGLSPLAEDLAPLVAAARERGIPVWGELEFFAQALTTLGANGYAPKVIAITGTNGKTTTTSLAGLLCERAGKTVAVAGNISPAMLDKLTEAIDAAALPDVWVLELSSFQLDTAHTFAPDAATILNITQDHLDWHGGFAAYAAAKGRIFGPRTVRVLNRDDAEVMKFAPPAAAADAPRAITFGLNEPAADGDYGLLRENGIAWLVEAVDRDAADAPATPSRRRKQEAANPPDIALKRLMPADALRIRGLHNAANALAAYALARAIDLPAAPLLHGLREYRGEPHRVEVIATLDGVDYVDDSKGTNVGATVAALDGLAQRAVLIAGGDGKGQDFEPLAAPVARWCRAVMLIGRDAPALREALADTGVPLADHATLESAVRAAGALAQPGDAVLLSPACASLDMFRNYAHRADVFRSAVEDIALEKGTTL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_CAMJE
Sequence: MITLKEALKYSKEELENLKKELNEKAKKEKKLGAYIEQFLDKDLSVSGEGVPVAIKDNISVKGWELTSASKILQGYIAPYDASAIVNLKANGFSPFGRCNMDEFAMGSSTASSCYGKTLNPLNFERVPGGSSGGSAAAVAGGLALASLGSDTGGSVRQPAAFCGCVGFKPSYGRVSRYGLASYSSSLDQIGVLTQNVEDAAILYDAIAGYDKMDSTSANIEFIKTVPNLNANKKLKIAVIENYVNDADSEVKNALLKTIDMLKANGHEIVYKNLLDSKFDIAAYYIIATAEASANLSRYDGVRYGKRSENIQNLKEMYVNTRSEGFGEEVKRRILLGTFVLSSGYYDAYYIKAQKARAFIKAKYEEILQDCDLIFMPVTPTTAFKFDTQKSPMQTYLEDVYTISVNLAGLGGISVPVAKDKEGLNISAQLICKAYDEQTLLDGALSLEQMIKN
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: TELO2_XENLA
Sequence: MDASQADRKVAPVSAVVKNAICELSRINDGERLMEVLLSLKCYLGTRENSTQTQEHAEFNRNHYTPFLEFLVAQMGPQWLDLLTLEKLELWDSFFLEGPADQAFLVLMDSLGKTGPSIRLDRCVHVLERFLQRGALAEVIREVCQQQLESNPTAVLHEAILGRISSLPDHLANCLQQHNKPVFYPNNYYPLLAGSIISVLQMVSDALRDGKNCSISFASQVVGKVCMQGRQKELLSVLVPRLKSLVQSDCIWQRICWRLVESVPDRWMEPVVIGIVQMAPGAEFLSQLLGDLVVKNKRTQFLLTKKMLFLQYGLKKDALQSILGYLSLDASRRYLLVKILRELLEVWSSGSVLKNSSQPQLLHVSRCLLICLGLLNKQEIESCKQDLLVSLTSGARNYLDSSVPAIRRMGMVVAECLSHRIDTEGPGLSFQYEEDEDTRDLKALLKPPHVFEADSADCVKNPEESSPSKSCPKAIEKSKMEAKADQASDSELDSDDDLAPYDMSADTELKKSKAPAYIRDCIEVLLSDDVEKLEVTMTCLATLIQANTSATKEVSVELTKILLHIDDKPSVERFTELRHAALVAVAVTDPVPVSQYLTGEFYSLNYSLRQRMDILDVLSSAAQSLSEKLSHEVSSESRSTGTGQHSIRSTTWTLAEAPADWRKVVEERIASKTRRFSKGQSVPTPVPAPNRYHAVAGHLFFPLIQNYDRQIVTFDLLGEDRLVLGRMVHTLGILMHLALHAPIASQMGKALLEFVWVLRFHIDAFVRQGLLFCISTVLLSVPWERLMTDMAEEVMETQSWLADVAERDSDDDCRRLALNGLFLMEKLRNNIHGTP
What is the function of this protein?
Regulator of the DNA damage response (DDR).  Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.  Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.  May be involved in telomere length regulation (By similarity).
What are the official names of this protein?
Telomere length regulation protein TEL2 homolog.
What is the protein family that this protein belongs to?
Belongs to the TEL2 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Nucleus. Chromosome, telomere.
Protein: UBP5_MOUSE
Sequence: MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRPKEEDTSAGTGDPPRKKPTRLAIGVEGGFDLTEDKFEFDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHAFNLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPALESGDGEQVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKVPLPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEELPDIAPPLVTPDEPKGSLGFYGNEDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILPGSSGPGSTSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDLDAEAAMDISEGRSAAESISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVVS
What is the function of this protein?
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.  Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly.  Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: HRDA_STRCO
Sequence: MRGGQRRASRLRPPTYRRRPPPAASILEVAPVQTQTLTQTDTAAGGAEPDAERGVLLAMPAQPGAGAALPHPGAPVDVPEHPEPPPPTRTESGGPSSDLFRQYLREIGRIPLLSAAEEVDLARRVEAGLFAEEKLRCSPGLDDRLALDLDRLVVLGRLAKRRLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGCEPTPQEVAAHLDLAPERVGEVLRLAQEPVSLHAPVGEEDDVALGDLIEDGDAASPVESAAFLLLRQHLEAVLSTLGERERKVVQLRYGLADGRPRTLEEIGRLFGVTRERIRQIESKTLSKLRDHAYADQLRGYLD
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
RNA polymerase principal sigma factor HrdA.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family.
Protein: FLGI2_VIBPA
Sequence: MKRIVLLLMSVALFSTAAQAARIKDVAQVAGVRSNQLVGYGLVSGLPGTGEANPFTEQSFAAMLQNFGIQLPPGTKPKIKNVAAVMVTAELPPFSKPGQQVDVTVSSIGSAKSLRGGTLLQTFLKGLDGQVYAVAQGNLVVSGFSAEGADGSKIVGNNPTVGLISSGATVEREIPNPFGRGDYITFNLLESDFTTAQRMADAVNNFLGPQMASAVDATSVRVRAPRDVSQRVAFLSAIENLEFDPADGAAKIIVNSRTGTIVVGKHVRLKPAAVTHGGMTVAIKENLNVSQPNSFSGGQTVVVPDSDIEVTEEKGKMFKFEPGLTLDDLVRAVNEVGAAPSDLMAILQALKQAGAIEGQLIII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein 2, Basal body P-ring protein 2.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: KAPCB_PIG
Sequence: MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPAPNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCGKEFCEF
What is the function of this protein?
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs.  PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.  Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.  Phosphorylates GPKOW which regulates its ability to bind RNA.
What are the official names of this protein?
cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
Protein: CYP9_CAEEL
Sequence: MAAEKRVFLDISVDENLIGRIEIRLFVEDAPKTCENFRALCTGEVGMTPNNKARLHYKQNEFHRIVKKFMIQGGDITEGDGRGGFSIYGRYFDDEKFKLKHSRPYLLSMANKGPNSNSSQFFITTAAAPHCNGKHVVFGEVVKGQNVVDYIDNLAVDDKSKPLAKVLISNCGELVKKKKPLKTDEELAAALEEKNNNARDNEIPKCPKSWLYRDDDNEKKHEMRNDKRREYRSRRSRSRSHEKNRDYKKENRGDSSRSQPRRDENGITVRGRGGVRFRRERSATPEHWRRNAPTKWVHDSHKHPEEDLV
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  Thought to function as a catalyst in the folding and modification of cuticle collagens.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase 9, PPIase 9, Cyclophilin-9, Rotamase 9.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
Protein: TATB_HAEDU
Sequence: MFDIGFSELILIFVVGLVVLGPQRLPVAIRTVMGWVRTIRSLATNVQHELAQELKLQELQESIKKAEAMNLTTLSPELTQTVEDLKQSAQKMQNDLNNANQIGKLTDEQVADIQQNIANAQPSEITEANELDESKLTAYYPPDDDLVSPSTTKLEQDKQNVN
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YDCY_SHIFL
Sequence: MSHLDEVIARVDAAIEESVIAHMNELLIALSDDAELSREDRYTQQQRLRTAIAHHGRKHKEDMEARHEQLTKGGTIL
What are the official names of this protein?
Uncharacterized protein YdcY.
Protein: ACCA_PSEPF
Sequence: MNPNFLDFEQPIADLQAKIEELRLVGNDNSLNIGDEISRLQDKSKTLTEDIFGKLTSWQIARLARHPKRPYTLDYIEHIFTEFDELHGDRHFSDDAAIVGGVARLEDQPVMVIGHQKGREVREKVRRNFGMPRPEGYRKACRLMEMAERFKMPILTFIDTPGAYPGIDAEERNQSEAIAWNLRVMARLKTPIIATVIGEGGSGGALAIGVCDQLNMLQYSTYAVISPEGCASILWKTAEKAPDAAEAMGITAERLKGLGIVDKVISEPLGGAHRDPAAAAASIRAELSSQLAMLKKFDNEALLKRRYDRLMSYGL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFQ_SHEPW
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQVESFDQFVILLKNTVSQMVYKHAISTVVPSRPFNVSNHQATNAQAGYNAQHDETDEK
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: K0930_RAT
Sequence: MLRAIAEERGRLSLRREVCGLGCFKDDRIVFWTWMFSTYFMEKLAPRQDDMLFYVRRKRAYTGSESTADGRKAEAEPEVEVEVYRRDSKKLPGLGDPDIDWEESVCLNLILQKLDYMVTCAVCTRADGGDIHIHRKKSQQVFASPSKHPMDSKGEESKMSYPNIFFMIDSFEEVFSDMTVGEGEMVCVELVASDKTNMFQGVIFQGSIRYEALKKVYDNRVSVAARMAQKMSFGFYKYNNMEFVRMKGPQGKGHAEMAVSRVSTGDTSPYGTEDSSPASPMHERVTSFSTPPTPERNNRPAFFSPSLKRKVPRNRIAEMKKSHSANDSEEFFREDDGGADLHNATNLRSRSLSGTGRSLVGSWLKLSRADGNFLLYAHLTYVTLPLHRILTDILEVRQKPILMT
What are the official names of this protein?
Uncharacterized protein KIAA0930 homolog.
Protein: RLMH_PSYA2
Sequence: MKVRILTVGNKMPKWVQTGFDEYHKRIQPMLNTEIVEIAAAKRAKNPSDANLAQYREQEGQAILAAHAAAGREQLWVLDVKGKMLSTENLADKLADGMQQGDDIALVIGGADGVSPEVLAKADVKWSLSALTLPHPLVRVVLMEQLYRAMSINHNHPYHRGN
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.