PharMolix/UniProtQA huggingface dataset:
Protein: SYI_HELPJ
Sequence: MKEYKDTLNLNETTFSMKGNLSVNEPKTYAKWQEQQAFKRMQNRKDNHGDFTLHDGPPYANGHLHLGHALNKILKDIVIKREYFKGKKIYYTPGWDCHGLPIEQQILEQLEKEKTSLENPTLFREKCRDHAKKFLEIQKNEFLQLGVLGDFEDPYKTMDFKFEASIYRALVGVAKKGLLKERHKPIYWSYACESALAEAEVEYKMKKSPSIFVAFDLKKEGLEKLKVKKASLVIWTTTPWTLYANVAIALKKDAVYALTQKGYLVAKALHEKLAALGVVDNAITHEFNSNDLEYLVATNPLNQRDSLVVLGDHVSLEDGTGAVHTAPGHGEEDYYLGLKYHLEVLMSVDEKGCYDEGIIHNQLLDKSYLGEHIFKAQKRIIEQLGDSLLLEREIEHSYPHCWRTHKPVIYRATTQWFILMDEPFIQNDGSQKTLREVALDAIEKVEFVPSSGKNRLKTMIENRPDWCLSRQRKWGVPLAFFIDKRTNKPCFESEVLEHVANLFEEKGCDVWWEYNIKDLLPPSYQDNAKHYEKVMHILDVWFDSGSTFKAVLEDYHGEKGQSPSDVVLEGSDQHRGWFQSSLLIGCVLNNQAPFKKVITHGFIVDEKGEKMSKSKGNVVSLDNLLKKHGSDVVRLWVAFNDYQNDLRVSQTFFIQTEQHYKKFRNTLKFLLANFSDMDLKNLERPHDFSPLDHFILEALETISAGVNSAFEEHDLVKGLNILMAFVTNELSGIYLDACKDSLYCDSKNNEKRQAIQMVLLAVASQLCYFLAPILTHTIEEVLEHSQVLRAFLQAKDVFDLKGISVLEKLHLKEFKKPENFEAVLALRSAFNEELDRLKKEGVVKNSLECAIEVKEKALCENLVEELLMVSFVGVAKEKLSETPAFTLFKAPFYKCPRCWRFKSELENTPCKRCEEVLKER
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END3_SCLS1
Sequence: MSNKRIEQSEIEKYWEIFASLSNGGTHLTGAQAAPVLKNSQLRDDQLERIWDLADVDNDGNLDFEEFCVAMRLIFDLVNGEYADVPPALPDWLVPESKAHLVQASRALTGRQVQFERVEDDDDTPGLKDGFDWYMSPSDKSKYEEIYAANRDGRGDITYTLYSSLDVPDTDVRSAWNLINPSAAPAISKDATLAFLHILNNRHEGYRIPRTVPPSLRASFERNQIDYQLDNQRVASPAQKWGVTGGEETSTGRKAKFGETYMSRLGLGGKSSYRPAGTDFSGTKTTEDWEEVRLKKQLAELEAKIEKVEAAAAARSGGRRDTKPALVKRELEQLLDYKRRELRDLESGEGRSKVGASLKGVADEIATVREQVDGLEAHLRSREQVLEELKQEIENEKISR
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein end3, Endocytosis protein 3.
What is the protein family that this protein belongs to?
Belongs to the END3 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: PSBN_LOBMA
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: YK99_SCHPO
Sequence: MPNEFISQSLSTLTNTPLNIQKKLLPITKYRNQLLYAVEQNQITIVLGHTGCGKTTQIPQFLYEAGWASQNGIIGCTQPRRLVAKSVSERVSLELNSPPGSLCGYSIQFDHNVSEKTKIKYMTDGILLNEIFFDPLLERYSIVILDEVHERTLSTDLLLGVLKRILEKRNDFRLVLSSASVDANKLSQFFGQDKVCTMSIEGKLFPVETLFLQKPTENYVDSAIETVININSTYPPGDILVFLSGRKEIEYCIKKIEDSLIHASEDCQTLVPLPLHAGLTVDEQMRVFNIYDGDFRKVIFSTNIAETSITIDGIVYVVDSGFNKQRIYNPYTRTSKLINVPISKSSAIQRSGRAGRTMRGKVFRLYTEKAYSLMKEEFEADILNCDMSPLVLFLKGLGLKNILQFPFFVRPPTVHLMAALEDLYLLGVLDESGNLTDPLGIQISNSFLDANISKALLTSNQFGCTHEILSIASILTAGEVFYNPTSSSKNDAFVAHSSFFANEGDIITALNVFESFVGNKKDLQWCRKNYLNYQTLRQALDIRTHLVRFLNKFSIPTAQRLPSSDCSKILKCLLDGFVRNVAHLQNDGSYKTIGGKQVWLDSSSVLHEKKTPWIMYSSAVESETQIFVKNISKIESFWLDKYYKREK
What is the function of this protein?
Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.
What are the official names of this protein?
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09, DEAH-box helicase C20H4.09.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL11_STRMK
Sequence: MAKKVVGYIKLQVKAGQANPSPPVGPALGQRGLNIMEFCKAFNAATQKLEPGLPVPVIITAYSDRTFTFITKSTPATTLLKKAAGISSGSKRPNTEKVGKVTRKQLEEIAKAKEPDLTAADLDAAVRTIAGSARSMGLVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PTN22_HUMAN
Sequence: MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSEISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQESAVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNSSSFLNFGFANRFSKPKGPRNPPPTWNI
What is the function of this protein?
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643).  Associates with and probably dephosphorylates CBL.  Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704).  Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343).  Dephosphorylates the immune system activator SKAP2 (PubMed:21719704).  Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208).  Promotes host antiviral responses mediated by type 1 interferon (By similarity).  Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).  Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286).  Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH6A_HUMAN
Sequence: MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKGETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYEMVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGITDLIKVKLTLEEEACLQKSAETLWEIQKELKL
What is the function of this protein?
Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441).  Significantly increases the transcriptional activity of JUN, when overexpressed.
What are the official names of this protein?
L-lactate dehydrogenase A-like 6A, LDHA-like protein 6A.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDK2_HUMAN
Sequence: MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
What is the function of this protein?
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2.  This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate.  Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism.  Mediates cellular responses to insulin.  Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability.  Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation.  Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress.  Plays a role in p53/TP53-mediated apoptosis.
What are the official names of this protein?
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, PDKII.
What is the protein family that this protein belongs to?
Belongs to the PDK/BCKDK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PLSY_SHEB8
Sequence: MSPLTQTLLMILAAYLAGSISSAVLVCRMRGLPDPRLQGSGNPGATNVLRIGGASSAAMVLFFDMLKGAVPSYLAYLMGIDAVSLGLIAIAACLGHIYPVFFGFKGGKGVATAFGAMAPIGDDLAICLMASWVVLLLISRYSSLAAILTALLAPLYTWWLDDRFTIPVAMLSTLIIIRHKDNIQRLLKGEESKVSRKKRPKKS
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR5_HAMD5
Sequence: MTDHVSLNYKDAGVDIHAGYLLVERIKKAVKQTHRPEVIGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAIDLKRHETIGIDLVAMCVNDLIVQGAEPLFFLDYFATGQLDVETAACVIAGIAEGCQQAGCALVGGETAEMPGMYQAKDYDLAGFCLGVVEKSKLINGHQNVKSGDTLLALASSGLHSNGYSLVRQVLNLSKKDPETWMLNGKSLADHLLEPTRIYVKSILTLIETQNVDIHAIAHLTGGGFFENIPRVLPKNTCVLIEESSWQWPCIFDWLQKTGNINKQEMYRTFNCGVGMIIALPENQADKTLDFLTSVGEKAWRIGRVDSSKTSSERIIFKKSILNN
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAA_BORBU
Sequence: MKRKAKSILFFLLSTVLFAQETDGLAEGSKRAEPGELVLDFAELARDPSSTRLDLTNYVDYVYSGASGIVKPEDMVVDLGINNWSVLLTPSARLQAYVKNSVVAPAVVKSESKRYAGDTILGVRVLFPSYSQSSAMIMPPFKIPFYSGESGNQFLGKGLIDNIKTMKEIKVSVYSLGYEIDLEVLFEDMNGMEYAYSMGTLKFKGWADLIWSNPNYIPNISSRIIKDDVPNYPLASSKMRFKAFRVSKSHSSKEQNFIFYVKDLRVLYDKLSVSIDSDIDSESVFKVYETSGTESLRKLKAHETFKRVLKLREKISMPEGSFQNFVEKIESEKPEESSPKN
What is the function of this protein?
Component of the outer layer of the flagella.
What are the official names of this protein?
Flagellar filament outer layer protein, Sheath protein.
What are the subcellular locations of this protein?
Periplasmic flagellum. Periplasm.
Protein: 4CLLA_ARATH
Sequence: MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQHFLEKP
What is the function of this protein?
Oxalyl-CoA synthetase acting exclusively against oxalate (PubMed:22447686, PubMed:27326693).  Follows a two-step reaction mechanism, wherein oxalate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield oxalyl-CoA (By similarity).  No activity with malonate, succinate, malate, acetate, formate, lactate, glycolate, glyoxylate or glutarate (PubMed:22447686).  Required for oxalate degradation, normal seed development and defense against oxalate-producing fungal pathogens (PubMed:22447686).
What are the official names of this protein?
Oxalate--CoA ligase, 4-coumarate--CoA ligase isoform 8, At4CL8, 4-coumarate--CoA ligase-like 10, Acyl-activating enzyme 3, Adenosine monophosphate binding protein 3, AtMPBP3, Oxalyl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_BURA4
Sequence: MATIKVDVVSAEEQIFSGEAKFVALPGETGELGILPGHTPLITRIRPGAVRIEVEGGNDEFVFVAGGILEVQPGAVTVLADTAIRGKDLDAAKAEEARKRAEETLQNAKSDLDLAKAQSELATAMAQLEAIQRLAKIRSRH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MEGG2_CAEEL
Sequence: MENCDDLSSDENLPPPGDHRREQSQERARVGNRDESVSSTNMRSIGGAVHNQQQLYWTDMYNGSNNLENFWLCFSGNTSLADDPTVQSDSSASTQSRTNQSGTIAQETDNRNASNFPPRSTTRRGQTYESRDESQGGQAPSHQNQVPGVDRDEYAGDRSNVSINLPSVDQWREYSFSDNSFQGESRTVQRRSSRATHRVKNQFGSIGDGRTSNNTSLQEPVIQDTRNRNRSESSSTMSSQSRTEHAPIFRLQYNYQREADNRSSRLVQIQGHSAPNNANGLQNTGGQAPDIGPEVNGQSSDTRAMNMGNQMAQGDSHVPMNFVPRPLSNGVPRLHGVPRLVDMYDYELAQRAHARRYPTSNMPYGFPNAGFQAPPHMGLWPNNQNADTRAMNMDNRSRDRTFQMPPANAQVPTSSLSGLFNSSINHGSGNQQFQMGQSSSGSAPQLPALPENFLMAHANSQIPTSSLSGLFNAMNHGSGNRMNHSSSGPAPQLPNLPESFLMAHGIGQVETRSPAGPSNSSINHGSGNQQFPVQQSSSRPAPQLPNLPESFLMAHGLSQIQTSSTAGPSNSSMNHGSGNQQFRMGQSSSRPAPQLPSLQESFLMAHGIAQVETSSTAGPSNSSMNHGSGNQQFPVQQSSSRPAPHLPDLIRQEEEFLNTLEFEQFARRLYNDLLPGVDPNYDSGTSTSETPVLKFSITLKAMLYDYWRTMVQMQYRGANINFLQSIINLNARSAALNSSNARASGSADVQNQTVSATVEGADDASANVNALSDLLAQSFPRQAEGEASRRNDIDHPEDDLNQADSPKSDNQSDKDPPSN
What is the function of this protein?
P granule component, which acts redundantly with P granule component meg-1 to promote P granule segregation during embryogenesis, and germ cell proliferation and differentiation in larval stages (PubMed:18202375, PubMed:21305687, PubMed:25535836).  Together with phosphorylated meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos (PubMed:25535836).  Together with dephosphorylated meg-1, promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos (PubMed:25535836).  Required for fertility (PubMed:18202375, PubMed:21305687).
What are the official names of this protein?
Protein meg-2, Maternal effect germ cell defective 2.
What are the subcellular locations of this protein?
Cytoplasmic granule. Note=Localizes to P granules in embryogenesis.
Protein: PYRF_SYNY3
Sequence: MTPDQVIVALDVPDLPKAIALVDRLPGVGFWKVGLELFVGAGPVILAELKDRGKRIFLDLKFHDIPNTMLGACLSASRYEVDLLTLHATAGSQALTLAAQAMAPLPHPPKLLAITLLTSIGDRQLREELQQPLAVDDYVNAMARLARNAGIDGAVCSPQEVAKLRQTCGPEFLLVTPGVRPLWSAPGDQQRVMIPAQAIAAGANYVVIGRPITADPSPEAAWERLCQDLAV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: CUTA_ECO45
Sequence: MLDEKSSNTTSVVVLCTAPDEATAQDLAAKVLAEKLAACATLIPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALLECLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
What is the function of this protein?
Involved in resistance toward heavy metals.
What are the official names of this protein?
Divalent-cation tolerance protein CutA.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU32_BRADU
Sequence: MATHKLLLLPGDGIGPEVMGEVKRLIDWLNSAGIAKFETDTGLVGGSAYDAHKVSISEGDMAKALAADAIIFGAVGGPKWDAVPYEVRPEAGLLRLRKDLGLFANLRPAVCYPALADASSLKREAVEGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIARVAFDLAKKRKNKVTSMEKRNVMKSGVLWNEVVTQVHKREYPDVTLEHQLADSGGMMLVKWPKQFDVIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGEVDVKSKKRKALYEPVHGSAPDIAGKGLANPIAMISSFGMALRYSFDMGALADKVDAAIAAVLASGLRTADIKSEGTTAASTTQMGEAILKELQKLHA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase 2, 3-IPM-DH 2, Beta-IPM dehydrogenase 2, IMDH 2.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_STAS1
Sequence: MGYRKLGRTSDQRKAMLRDLATSLIVSERVETTEARAKELRSVVEKLITLGKKGDLASRRQAAKTLRNVEILNEDETVQTALQKLFGEVAERYTERQGGYTRILKVGPRRGDGAESVIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: TLCD2_HUMAN
Sequence: MAPTGLLVAGASFLAFRGLHWGLRRLPTPESAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTLGKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLLLLSRQAPSLAFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILGIRILVNDVLQSRPHPPSPGHEKTRGTRTRRDNGPVTSNSSTLSLKD
What is the function of this protein?
Regulates the composition and fluidity of the plasma membrane (PubMed:30509349).  Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349).  Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349).
What are the official names of this protein?
TLC domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the TLCD family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX2_BALBO
Sequence: MAYPFQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIITLMLTTKLTHTSTMDAQEVETVWTILPAIILILIALPSLRILYMMDEVNNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSDLKPGELRLLEVDNRVILPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLFYGQCSEICGSNHSFMPIVLELVPLEIFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DCTP_BURCM
Sequence: MTHRFPRSRTALAVALMAGFAMSAQARVFRSADVHGDSFPTNMAVKFMGDELSKLTGGKDSIKVFGNSALGSEKDTVDQVRIGAIDMARVNGASFNEIVPESLIPSFPFLFRDVDHFRKAMYGPAGQKILDAFAAKGMIALTFYESGARSIYAKRPVRTPADMKGLKVRVQPSDLMVDEIRAMGGTPTPMPFAEVYTGLKTGLVDAAENNLPSYEETKHFEVAPDYSETQHAMTPEVLVFSKKIWDTLSPQEQAAIRKAAADSVPYYQKLWTAREASAQQAVTKGGANILPAAQVDRAAFVKAMQPLWTKYEKTPQMKQIVDEIEATK
What is the function of this protein?
Solute-binding protein that binds D-galacturonate and D-glucuronate (in vitro) (PubMed:25540822).  Probably part of a tripartite ATP-independent periplasmic (TRAP) transport system that mediates solute transport into the cytoplasm.
What are the official names of this protein?
Solute-binding protein Bamb_6123.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 7 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: F16PA_ECOHS
Sequence: MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POTA_AGGAC
Sequence: MENTVQNKPIIELRSITKSYGSNTIIKDFNLTINNGEFLTILGPSGCGKTTVLRLLAGLEELDSGNIILDGEDITNVPAEKRHVNTVFQSYALFPHMTIFENVAFGLRMQKVPEAEIKPRVLEALRMVQLEEMADRKPTQLSGGQQQRIAIARAVVNKPKVLLLDESLSALDYKLRKQMQYELKVLQRQLGITFIFVTHDQEEAITMSDRIVLLRKGKIAQDGSPREIYEEPANLFVARFIGEINVFDATVIERKSENVVLANVEGRVCDIYTDIPVKKDQQLQVLLRPEDIVIKELDEHEHSKAIIGHIIDRTYKGMTLESTVEFEQNGKRGLVSEFFNEDDPHMDHSIGQRVGITWHEGWEVVLNDEDNQ
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.