PharMolix/UniProtQA huggingface dataset:
Protein: ECS1_ARATH
Sequence: MASSIVSSMFLFLLLLLVFPHIDNVLGARMELRELGEINYADPLGFTRPIVPIHVPGFPPRRPTIPQLPPYRPRRCPFCYPPPPPKAFPKNSPSH
What is the function of this protein?
Maybe involved in defense responses to X. campestris, but probably not a X. campestris pv.  campestris race 750 (e. g.  Xcc750) resistance gene; according to genetic data, linked to a locus influencing resistance to Xcc750.
What are the official names of this protein?
Protein ECS1, Protein CXc750.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: THIC_NOSP7
Sequence: MRTEWVAKRRGQVNVSQMHYARQGVITEEMHYVAQRENLPTDLIRDEVARGRMIIPANINHTNLEPMAIGIASKCKVNANIGASPNSSNLQEEVDKLNLAVKYGADTVMDLSTGGGNLDEIRTAIIKASPVPIGTVPVYQALESVHGTIENLTADDFLHIIEKHAQQGVDYQTIHAGILIEHLPLVRNRITGIVSRGGGILARWMLHHHKQNPLYTHFQDIIEIFKRYDVSFSLGDSLRPGCTHDASDEAQLAELKTLGQLTRKAWEDDVQVMVEGPGHVPMDQIEFNVRKQMEECSEAPFYVLGPLVTDIAPGYDHITSAIGAAMAGWYGTAMLCYVTPKEHLGLPNAEDVRNGLIAYKIAAHAADIARHRPGARDRDDELSKARYNFDWNRQFELSLDPERAKEYHDETLPADIYKTAEFCSMCGPKFCPMQTKVDADALTELEKFLAKEPVTQS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: G6B_HUMAN
Sequence: MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV
What is the function of this protein?
Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor.  Isoform A may be the activating counterpart of isoform B.
What are the official names of this protein?
Megakaryocyte and platelet inhibitory receptor G6b, Protein G6b.
What are the subcellular locations of this protein?
[Isoform E]: Endoplasmic reticulum. Golgi apparatus. SUBCELLULAR LOCATION: [Isoform D]: Endoplasmic reticulum. Golgi apparatus. SUBCELLULAR LOCATION: [Isoform B]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform A]: Cell membrane; Single-pass type I membrane protein.
Protein: DUT_SALTY
Sequence: MKKIDVKILDPRVGQQFPLPTYATSGSAGLDLRACLDDAVELAPGATTLVPTGLAIHIADPSLAAVMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSIWNRGQDSFTIEPGERIAQMVFVPVVQAEFNLVEAFDATERGEGGFGHSGRK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: CYHEG_AFREN
Sequence: GLPCGESCVYIPCISTVLGCSCSNKVCYRD
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide hyen-G.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: DTX_COROM
Sequence: MSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYAVSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS
What is the function of this protein?
Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to elongation factor 2.  Fragment A is responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.
What are the official names of this protein?
Diphtheria toxin, DT, NAD(+)--diphthamide ADP-ribosyltransferase.
Protein: NOSIP_MACFA
Sequence: MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDNAQPGPSVGPPSKDKDKVLPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA
What is the function of this protein?
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face.  Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity).  Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity).
What are the official names of this protein?
Nitric oxide synthase-interacting protein, E3 ubiquitin-protein ligase NOSIP, RING-type E3 ubiquitin transferase NOSIP.
What is the protein family that this protein belongs to?
Belongs to the NOSIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle.
Protein: SUB1_TRIVH
Sequence: MGVFRFISISLAAVSAANAAQILSMPHAQTVPNSYIVMMKDDTSDDDFNHHQSWLQSTHTHNITRRATIQNAGMRHKYNFSKMKGYSGIFDEETIKDIAKDPKVMFVEPDTIISVHGKVEQSNVPSWGLARISNPQPGAGSYIYDSSAGEGITVYSVDTGVDVNHEDFEGRAIWGSNQVNDGDDRDGSGHGTHTSGTMVGKEFGIAKKAKLVAVKVLGNDGSGPTSGIVAGINWSVEHARQNGGTKKAVMNMSLGGSSSSALNRAAAQAVEQGMFLSVAAGNDNQDAQSSSPASEPSVCTVGSSAEDDSRSSFSNWGPAIDLFAPGSNIISARPGGGSQSMSGTSMAAPHVAGLAAYLMALEGISGGAVCDRLKELGTSSITDAGPGTPTNVLINNGGAKGGKPNPNPAPSPSPSPSQPSEPQQPTPSQPGQPGEPFPGEPQQPTPSQPGQPGEPFPGEPFPGEPFPGEPFPGESAPAPAPQHPHTPYPGGDNFDFDGFWKKYFGGEHWRKMFSSFWN
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FIEF_ECO7I
Sequence: MNQSYGRLVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNLLVVRYSLQPADDNHSFGHGKAESLAALAQSMFISGSALFLFLTGIQHLVSPTPMTDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHYQSDVMMNGAILLALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDEERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDSLPLVQAHMVADQVEQAILRRFPGSDVIIHQDPCSVVPREGKRSMLS
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPD_ECO81
Sequence: MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPRITVVDGGEERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: RBPS2_MOUSE
Sequence: MSNLKPDVEHCTGAGTGSPLEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTSRQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKSKLIATPNPTSVHPALGAHLIARDPYDLMGTALIPASPEAWAPYPLYTTELTPAISHTTFTYPAATAAAAAAATLHAQVRWYPSSDTTQQGWKYRQFC
What is the function of this protein?
RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (By similarity).  Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway.  Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity).
What are the official names of this protein?
RNA-binding protein with multiple splicing 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_STRAW
Sequence: MAGEQHAQPTSVPAEAREKHAQLAEQIEEHRFRYYVKDAPVVSDAEFDTLLRSLEALEEEYPELRTPDSPTQKVAGGYETEFTAVQHRERMLSLDNAFDDLGLAAWAERVAKDVGTSDYHFLCELKVDGLAVNLTYEHGRLTRAATRGDGRTGEDITPNVRTIAEIPDRLKGDRIPDLVEIRGEVYFPMEKFEELNARLVEAGDKPFANPRNAAAGSLRQKDPRVTATRPLHMVVHGIGARQGFDIDRLSQAYELLREWGLPTTRYARVVDDLDGVREFIAYYGENRHSVEHEIDGVVVKLDEIPLQGRLGSTSRAPRWAIAWKYAPEEVNTKLINIRVGVGRTGRVTPYAQVEPVTVAGSEVEFATLHNQDVVKAKGVLIGDTVVLRKAGDVIPEILGPVVDLRDGTERAFVMPAECPECGTPLAPAKEGDVDLRCPNARTCPAQLRERLFYLAGRKSLDIEQFGYVAAAALTKPLEPAEPPLLDEGDLFDLTIERLLPIKAYVLDQDSGLPKRDPKTGEEKVATVFANQQGEPRKNAISMLDNIAAAKERPLARILTGLSIRHVGPVAAEALARAFRSIDRIDQATEEELKDTDGVGPIVAAAVKQWFAEDWHREIIRKWKAAGVRMEDERSGEDEGPRPLEGLTVVVTGTLEHHTRDGAKEALQSRGAKVTGSVSKKTSFVVVGDNPGSKYDKAMQLKVPVLNEAGFAVLLEQGPEAAAEVALPTEE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: CYSH_ALISL
Sequence: MPKLQLSELLSLNKVEQILRLAEINTELEQLTAQERVSWALDNLEGKPAVSSSFGIQAAVMLQLVTDVKSDTPVILTDTGYLFPETYQFIDTLTERLNLNLQVFTADETPMWQEARYGKLWEQGVDGLKHYNRLNKVQPMRRALDQLQVGVWFSGLRRDQSSSRSHLPILSIQNGVFKFLPVIDWSNQEVHYYLEEKGLPYHPLRDEGYLSVGDTHTTQKWEPGMKEEDTRFFGLKRECGLHEDDAEAEGSGI
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM17_BOVIN
Sequence: MRLSFAAAISHGRVYRRLGLGPESRIHLLQNLLTGLVRHERIEASWARVDELRGYAEKLIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYQGQNGGYTRMLQIPNRNQQDRAKMAVIEYKGNCLPPLPLPRRDSNLTLLNQLLRGLRQDQEASTRSSHPAQTPEV
What are the official names of this protein?
39S ribosomal protein L17, mitochondrial, L17mt, MRP-L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RL15_PYRFU
Sequence: MIRRRKKVRKLRGSHTHGWGCKKKHRGGGSKGGRGMAGTGKRNKSKWTWTIKYAPDHLGKRGFSRPPEVQREVRVVNLKFIDEHLDELMQMGIAYEEGGKIIVDVTQFADKVLGTGKLTRPLVIKARAFSPKAEEKIKAAGGEAVLV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15, Large ribosomal subunit protein uL15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PSBL_ARAHI
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: BALF1_EBVG
Sequence: MNLAIALDSPHPGLASYTILPRPFYHISLKPVSWPDETMRPAKSTDSVFVRTPVEAWVAPSPPDDKVAESSYLMFRAMYAVFTRDEKDLPLPALVLCRLIKASLRKDRKLYAELACRTADIGGKDTHVRLIISVLRAVYNDHYDYWSRLRVVLCYTVVFAVRNYLDDHKSAAFVLGAIAHYLALYRRLWFARLGGMPRSLRRQFPVTWALASLTDFLKSL
What is the function of this protein?
May play a role in host B-cell survival by preventing host apoptosis.  The survival of infected B-cells is a key step to induce host cell differentiation into memory cells, thereby assuring long term infection of the organism.  May also play an active part in oncogenesis in Burkitt's lymphomy and nasopharyngeal carcinoma (By similarity).
What are the official names of this protein?
Apoptosis regulator BALF1.
What is the protein family that this protein belongs to?
Belongs to the Epstein-Barr virus BALF1 family.
Protein: Y2104_STAAT
Sequence: MKDLTMLLDELKDMSFFNKGDICLIGCSTSEVIGEKIGTVGSMEVAETIFNALDVVSKETGVTFAFQGCEHINRAITIEKSQYNPLTMEEVSVVPDVHAGGSLATYAFQHMKDPIVVEHITVPCGIDIGQTLIGMHIKHVCVPVRTSVKQVGQAIVTIATSRPKKIGGERAKYQ
What are the official names of this protein?
UPF0340 protein USA300HOU_2104.
What is the protein family that this protein belongs to?
Belongs to the UPF0340 family.
Protein: LPXA_RICRS
Sequence: MSNSNIHTTAVIAEGAKLGKNVKIGPYCIIGPEVVLNDNVELKSHVVIEGITEIGENTVIYPFASIGQPPQILKYANERSSTIIGSNNTIREYVTVQAGSQGGGMMTRVGNNNLFMVGVHIGHDCKIGNNVVFANYVSLAGHIGVGDYAIIGGLSAVHQYARIGEYSMIGGLSPVGADVIPFGLVSSKRAVLEGLNLIGMNRKGFDKVKSLSALKAIEEIFSGEGNFAERIKQVAEKYNNNSIVIQIIDFLNQDSSRAFCRFEK
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_SHEWM
Sequence: MSGNKVEVDKRRTFAIISHPDAGKTTITEKVLLFGNALQKAGTVKGKKSGQHAKSDWMEMEKDRGISITTSVMQFPYNDALVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDSAKGVEQRTIKLMEVTRLRDTPIVTFMNKLDRDIRDPLELMDEVEEVLNIACAPITWPISSGKEFKGVYHLLRDEVILYQSGQGHTIQDSRIIKGLNNPELDEAIGAYAAEVREELELVLGASNEFDLEMFLAGELTPVFFGTALGNFGVDHILDGIVEWAPKPQARETEVRDIQPEDEKFSGFVFKIQANMDPKHRDRVAFMRICSGRYEQGMKMHHVRLGKDVNVSDALTFMAGDRNRAEVAYPGDIIGLHNHGTMRIGDTFTQGEKFRFTGIPNFAPEMFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPIDSNDLIVGAVGVLQFEVVVGRLKSEYKVEAIYEGISVATARWVYCDDERKLEEFRRKCSNNLALDGGDNLTYIAPTMVNLNLSMERYPDIQFAKTREN
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGALC_ASPFN
Sequence: MFGSPKRAALAAASLLAIFGNGPSVMAQETSSNNAVVADGKTFALNGENVSYRFRVNETTGDLVSDHFGGSITGDLFPGFGAEALGGWVGLAGRFRREFPDHGRGDFRIPAVRIRQEAGYTVTDLQYQSYSVIPGKPALPGLPSTFGSEEDVTTLVVHLYDNYSSIAVDLSYSIFPKYDAIVRSANVTNKGTQNITVEALSSFSFDFPYEDLEMISLRGDWAREAHRQRRKVEYGLQGFGSSTGFSSHLHNPFLAIVHPSTTESQGEAWGFNLVYTGSFSVDVEKGSQGLTRALLGFNPSQLSWQLGAGETLTSPECVSVYSSDGIGGMSRSFHRLYRNHLIKSKFATSDRPPLLNSWEGLYFDYNESTIYRLAEESAALGVKLFVMDDGWFGDKYPRVSDNAGLGDWVPNPDRFPDGLTPLVEDVTKLKAGNSSTDLRFGLWVEPEMANPNSTLYHEHPDWVLHAGQYPRTLQRNQLVLNLALPEVQDYIIDEITNILNSSAISYVKWDFNRAMHETPSPSNDHEYILGMYRVFDTLTTRFPDVLWEGCASGGGRFDPGVLEYFPQIWTSDNTDALMRITIQLGTSLAYPPSAMGAHLSAVPNAQTGRTIPVKFRGHVAMMGGSFGLELDPAELQEDEKAEVPGLIALAEKVNPIILTGDMWRLRLPEESNWPAVLFISEDGNQAVLFYFQLGPNVNHATPWLRLQGLDPKATYSVDGNGSYSGATLMNMGLQYKFESDYDSKVVFLQKQ
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase C, Melibiase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FZD2_MOUSE
Sequence: MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGSPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV
What is the function of this protein?
Receptor for Wnt proteins.  Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
What are the official names of this protein?
Frizzled-2, Fz-2, mFz2, Frizzled-10, Fz-10, mFz10.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: Y4801_HAHCH
Sequence: MLIVVSPAKTLDYETPVPTTENTQPRFLPQSAELVDILKQKEPWRLSELMGVSDELATLNANRYQSWSLPFNEDNARQALFAFKGDVYTGLDAYSLEQDAISAAQRQLRILSGLYGVLRPLDLMQPYRLEMGTRLQNAKGANLYRFWGDTLTQSLNEEVRETGADVLINLASNEYYKAVNEKKLAVPVITPMFLDMKGGKYKVVSFWAKKARGMMTRYILQNRLQRPEEIKNFDTDGYSYNPALSDGAQWAFTRDH
What are the official names of this protein?
UPF0246 protein HCH_04801.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: Y0496_DICDI
Sequence: MAVSKNIKSNVSTHVTKKATKKTTNNGEESKTVKKAVNNKLLSDEINEILHSSENIKKSIDPESMDYFGDSAKVSKSDENFGEIEDDNRGTRLKGDIPTEFTSGKYSGKKSSRKDNDMEEDDELDQDNEYDIFGGDKQDDDDGDDDNSEDLDDAFDFQDKQDDDDDDDDKEDDDEDDDDDENVVVSSNIDRADMLFKKLQKQEKEEEKQPKLVGHTNEADEMEKAQNTKNQTALYNEFLTTRILLQKTINCANKLPKPKIYKEFLELNDESLQKKFKETKTASCLLISELYNLQSELIDLNDEIPKQQQSKKRIRPDQSLSEIWNTIEEQNQRLDQFHNQTITKWNNRISVTSSINSGGKGGNNLKSLNQSILSQIQNTLNDFERLQKRTKLKRTTYRIIGEKQQQLSSANSIDQNEEEKDEYDDEIFDDTDFYQTLLKDLEANNSEENEVGSQYWIEMRNLKKKKKKKVNQKASKGRILRYEVFPKLENFMTPQSLPIPDWNIDQLYQNLFGGLGNVNINLN
What are the official names of this protein?
Putative uncharacterized protein DDB_G0270496.
What is the protein family that this protein belongs to?
Belongs to the AATF family.
Protein: GATB_METSB
Sequence: MTTRAKPSKLIKGATGDFEIVIGMEIHAQVTSRSKLFSGASTEFGGEPNAHVSLVDAAMPGMLPVINQECVAQAVRTGLGLEAQINLRSVFDRKNYFYPDLPQGYQISQYKSPIVGEGVVAVDVSPTEQIKVGIERLHLEQDAGKSLHDQSATESLVDLNRSGVALMEIVSKPDMRSSDEARAYVTKLRTILRYIGSCDGNMEQGSLRADVNVSVRRPGEPLGTRCEIKNVNSIRFIGQAIEVEARRQIGVIEDGGVVQQETRLFDPGRGETRSMRSKEEAHDYRYFPDPDLLPLEFDQAYVDGLKAGLPELPDAKKERFIAEYGLPAYDAGVLVADKETADYYEAAVRHGGAKRDPKLVANWLTGDVAAYANSVGLSVAQTHIKPGQIASLVDLIADGTISGKIAKDVLSILIAEEKDADPKDIVEARGLRQVTDTGAIAAAVDAIIKANPDKVAQAQAKPSMLGWFVGQVMKQTGGKANPQAVNDELKAKLGI
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: GUAA_CORGL
Sequence: MSLQTNHRPVLVVDFGAQYAQLIARRVREAGIYSEVIPHTATADDVRAKNAAALVLSGGPSSVYAEGAPSLDAEILDLGLPVFGICYGFQAMTHALGGTVANTGKREYGRTDINVAGGVLHEGLEACHKVWMSHGDAVSEAPEGFVVTASSEGAPVAAFENKERKMAGVQYHPEVLHSPHGQAVLTRFLTEIAGLEQNWTAANIAEELIEKVREQIGEDGRAICGLSGGVDSAVAGALVQRAIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDERQAFLSKLAGVTEPEAKRKAIGAEFIRSFERAVAGVLEEAPEGSTVDFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDVEFKLVEPLRDLFKDEVRAVGRELGLPEEIVGRQPFPGPGLGIRIIGEVTEDRLETLRHADLIARTELTEAGLDGVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRLPYEVLEKISTRITNEVPDVNRVVLDVTSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RECU_LIMF3
Sequence: MTIRYPSGQQPPNVGRAEQPIVAPHSSSFAKRGMSLEKEINDANRYYLATEQAVIYKKPTPIQLVKVDYPKRSAAVVKEAYFKRPSTTDYNGVYQGYYVDFDAKETRGKLSFPLKNFHQHQVDHFRRCLAQGGVCFAFIRFTTLDLTYLLPASDLIAFWDQQGRGGRKSVPLTTIKDRGFRVKTGLTPVLDYLPALDQLIAANQAKGADHE
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALGH_PSEAE
Sequence: MKQSSPTYLKHHFLIAMPHMADPNFAQTVTYLVEHNEQGAMGLVINRPSGLNLAEVLEQLKPDALPPARCQHIDIYNGGPVQTDRGFVLHPSGLSYQSTLELGELAMSTSQDVLFAIAAGTGPEKSLISLGYAGWEAGQLEAELSDNAWLTCPADPAILFDLPPEERLSAAAARLGVNLSLLTAQAGHA
What are the official names of this protein?
UPF0301 protein AlgH.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: Y535_SACS2
Sequence: MLSGILGWGAYIPRYRIKVEDIAKMWGYDEAVVKSLGLTEKSVPGHDEDSTTIAWESSINAIKRAQVDTSKIRLVLFGSESKVYAVKPTSTILIDALGINNYSATADMEFACRAASVGLRLASSFVLHNNDSYALVIGADTAQSNPGDVLELSSAAAGVAFVVGKTDEKHSAAVIEYSSSYTSDTPDFWRRDGTPYPVHGEGFTGEPAYFHHIISAVNDLLQNSGLKISDFDYFVFHQPNGKFPIQVAKKLGVPLEKVKQGLVSPYIGNPYNASALLGLAKVLDIAKPGERILVAPFGSGAGSDAFSILVSEGILAKQKLAKTVEYYINNKKLVSYAEYAKYTNKIKVYE
What are the official names of this protein?
UPF0219 protein SSO0535.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. UPF0219 family.