PharMolix/UniProtQA huggingface dataset:
Protein: ANFD_HELGE
Sequence: SERGCAYCGAKHVIGTPMKDVIHISHGPVGCTYDTWQTKRYISDNDNFQLKYTYATDMKEKHIVFGAEKLLKKNIIEAFQAFPDIKRMTIYQTCASALIGDDINAIAQEVMDELPDVDIFVCNSPGFAGPSQSGGHHKINIAWIDQKVGTVEPKITSDYVINYVGEYNIQGDQEVMLDYFKRMGIQVLSTFTGNGSYDDLRAMHRAHLNVLECARSAEYICNELRVRYGIPRLDIDGFGFEPLSTSLRKIGLFFGIEDRAQAIIEEETARWKPELDWYKE
What is the function of this protein?
This iron-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.  Other nitrogenase complexes utilize a molybdenum-iron protein or a vanadium-iron protein.
What are the official names of this protein?
Nitrogenase iron-iron protein alpha chain, Dinitrogenase 3 subunit alpha, Nitrogenase component I.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: RL2_STRP4
Sequence: MGIRVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVALKSKAGRNNNGRITVRHQGGGHKRFYRLVDFKRNKDNVEAVVKTIEYDPNRSANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPEADIKVGNALPLANIPVGTLIHNIELKPGRGGELVRAAGASAQVLGSEGKYVLVRLQSGEVRMILGTCRATVGVVGNEQHGLVNLGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RL35_SYNJA
Sequence: MPKIKTRKAAAKRFRLTGSGKFMRRRAGHNHLLEHKTSNRKRKLAGVALVSKQDLANVRLMLPNTH
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: AMPR_CITKO
Sequence: MRSNLPLNALRAFEASARHLSFTRAALELCVTQAAVSQQVRILEDRLNRVLFKRLPRGLEMTDEAQALFAVLTDAFGQIDTIFRQFEGGEYREVLTVAAVGTFAVGWLLPRIEQFRQAHPFVELRLRTNNNVVNLAAEGLDFAIRFGNGLWPATHNEMLFEAPLTVLCTPETAQRLRRPADLLQENLLRSYRVDEWDNWFAAAGVTAERINGAVFDSSRLMVETVIHTGGAALVPAVMFARELAAGQLVRPFDIEIQMGYWLTHLKSKPMTPAMEIFRDWIVKMA
What is the function of this protein?
This protein is a positive regulator of gene expression of beta-lactamase (AmpC).
What are the official names of this protein?
HTH-type transcriptional activator AmpR.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSA2_PLAFI
Sequence: MKVIKTLSIINFFIFVTFNIKNESKYSNTFINNAYNMSIRRSMEESKPPTGAVAGSGAGAGSGAGAVAGSGAGAVAGSGAGAVAGSGAGAVAGSGAGAVAGSGAVAGSGAGNGANPGADAERSPSTPATTTTTTTTNDAEASTSTSSENRNHNNAETNPKGKGEVQKPNQANKETQNNSNVQQDSQTKSNVPRTQDADTKSPTAQPEQAENSAPTAEQTESPELQSAPENKGTGQHGHMHGSRNNHPQNTSDSQKECTDGNKENCGAATSLLNNSSNIASINKFVVLISATLVLSFAIFI
What is the function of this protein?
May play a role in the merozoite attachment to the erythrocyte.
What are the official names of this protein?
Merozoite surface protein 2, Merozoite surface antigen 2, MSA-2.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: PDE1A_BOVIN
Sequence: MGSTATETEELENTTFKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVIDLKKNIEYAASVLEAVYIDETRRLLDTDDELSDIQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPRFRSIVHVVQAGIFVERMYRKSYHMVGLAYPEAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNVLINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGLDKAKTMSLILHAADISHPAKSWKLHHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIIIPLIEEDSKTKTPSYGASRRSNMKGTTNDGTYSPDYSLASVDLKSFKNSLVDIIQQNKERWKELAAQGEPDPHKNSDLVNAEEKHAETHS
What is the function of this protein?
Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes.  Has a higher efficiency with cGMP compared to cAMP.
What are the official names of this protein?
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Cam-PDE 1A, 61 kDa Cam-PDE.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Protein: CLPP_GLAP5
Sequence: MAVIPMVVEQSSKGERAYDIYSRLLKERIIFLNGGVEDEMAKLIIAQMLFLEAEDPEKDIYLYINSPGGVVTAGLAIYDTMNFIKPDVSTLCMGQACSMGAFLLSAGAKGKRFALPNSRVMIHQPLGGYRGQATDIQIHAQEILKLKEMLTRKMAEHCSQPFEKVAQDTERDNFMSAEEAKAYGLIDDVVTKR
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IME1_YEAST
Sequence: MQADMHGKLHAALEDGFFLFPFEQQQQPNIYYDTTTDQEDRPCFSFGSTISPRSWHFEKSDKIASSQLQNLVHTQPIHLINPQILFNEEFLNLENIDSQPISKETKTTKDCTMATGPERGKKSSESTRSSSLSSLFSNDESASTFHSSFNNHDNFQKSNRNGDDIDISDTIKYETNTNAQKDIKIFQENFEFNEFPYTQDFYPYTTNYTYSKPTNIHESINSKNTDSYSQYQDQFPPHTDNIHSFNNRHYSNHKSTNCNYYNNTSNNNNASDNVYEADPFIDEPQVPSYYYPLEIAFDVEKSPPPSLQKLNSKELEFLKKLNSKLSRYAAAYSFSSSNDQDYYDKVRFQEISYKFSKTYS
What is the function of this protein?
Transcription factor required for sporulation and for early sporulation-specific genes expression.  Positive regulator of SME1/IME2 expression.  Directly activates expression of SLZ1 during meiosis.
What are the official names of this protein?
Meiosis-inducing protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: MG44_TARMA
Sequence: VKRPMNAFMVWSQNERRKIMDQWPDMHNAEISKSLGRSSQLLQDSEKIPFVKEAGRLRLKHMADYPNYKYRP
What are the official names of this protein?
SRY-related protein MG44.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMG_WIGBR
Sequence: MCSCYKEIDIIIVGGGHAGTEAAAVAAKMKCNTMLITQNIDTIGQMSCNPSIGGIGKGHLVKEIDAMGGIMGIAADNSGIQFRTLNSSKGPAVRATRAQIDRKLYSSLIQKILSNQKNLYLLQQEVIDILVEKNKIKGVVTNAGLIIKSKIVIITTGTFLNGKIHIGNKQYVSGRSGEFSSIKLSQILKEKFCFRINRLKTGTPPRIDLKSVNFSKLESQYGDTPIPQFSFMKFVGIRPKQLPCYITYTNKNTHNIIIDNIKHSPIYNGSIKGIGPRYCPSIEDKVVRFSKKESHQIFLEPEGLNNYEIYPNGISTSLPLNLQIKIIRSIKGLESANITRPGYSIEYDFLDPRDLKLTLESKIISGLFFAGQINGTTGYEEAAAQGLLSGINAALMLKNGSFWFPKRSQAYLGVLIDDLCTLGTKEPYRMFTSRSEHRLIIREDNADLRLTEIGRKLGIIEDDRWNNFYNKKNIIYKEIKNLKNTKILFNKEEKNKINLNINKSGSITAEEILRRPEITYNDLICYNFIKRKLKDEEIIKQIEIQIKYAGYIKRQEKEINKKTYYDNIILPNEINFKKISGLSKEVIEKLNIFKPTSIGQAIKISGITPAAISIILIWLKKNNLMYNK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDLI4_HUMAN
Sequence: MPHSVTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKPPEGYDVVAVYPNAKVELV
What is the function of this protein?
Involved in reorganization of the actin cytoskeleton and in regulation of cell migration.  In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome.  Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers.  Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration.
What are the official names of this protein?
PDZ and LIM domain protein 4, LIM protein RIL, Reversion-induced LIM protein.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Synapse, synaptosome. Note=Localizes to actin stress fibers in nonmuscle cells. Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and alpha-actinin. Targeted efficiently to spines via its PDZ domain-mediated interaction with the alpha-actinin/actin cytoskeletal complex. Localizes to synaptosomes in brain (By similarity). Colocalizes with F-actin (PubMed:10826496). Colocalizes with TRIP6 at cell-cell contacts and lamellipodia (PubMed:10826496). In the cytoplasm, displays a fibrillar pattern with characteristic thick fibers and occasional clusters. Colocalizes with the actin stress fibers. Oxidative stress induces redistribution from cytoskeleton to cytosol (PubMed:21636573). Colocalizes with SRC at the perinuclear region, but not at focal adhesions (PubMed:19307596). SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Stains more diffusely in the cytoplasm with thin fibers forming a dense mesh-like pattern.
Protein: KHSE_RHOOB
Sequence: MTQTLPAGLTVTARVPASSANLGPGFDTLGIALGLYDEITVTTTASGLNIRVEGEGADDVPWGPSHLVVRAIERGLESAGVWADGLDVVCRNVIPHSRGLGSSASAVVGGLAAANGLAIKLDPELGLSLDQLVQLSSEFEGHPDNASASVLGGAVVSWSCAGEQADGAPAATDIYSAVALKVHPAIRVVALVPGERSSTAHTRGLLPETVPHRDAAFNVSRGALAVVALTERPDLLMAATEDRLHQTQRAPALPLTTRWIAVLRKAGIAATVSGAGPTVLALTTEPFPVELRAQAEAEGLQVLELDVADGVRTS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KBX1_TITSE
Sequence: MERKLALLLILGMVTLASCGLREKHVQKLVALIPNDQLRSILKAVVHKVAKTQFGCPAYEGYCNDHCNDIERKDGECHGFKCKCAKD
What is the function of this protein?
Specifically blocks voltage-gated potassium channels Kv4. 2/KCND2.  When measured at the peak current, the blocking effect of this toxin is about 65% and shows an IC(50)=652 nM (PubMed:27346450).  However, when measured at a later moment of the depolarising test pulse (500 ms), a 100% block of the current is observed with an IC(50)=313 nM (PubMed:27346450).  This may indicate a preference of the toxin for binding the inactivated state of the channel.  The inhibition is completely reversible (PubMed:27346450).  Using intraplantar injections on rat, this toxin induces overt nociception (licking and lifting behaviors) and decreases the mechanical nociceptive threshold (hyperalgesia).  Furthermore, the hyperalgesia is prolonged when intrathecal injections are performed (PubMed:27346450).
What are the official names of this protein?
Potassium channel toxin TsTXK-beta, TsTXKbeta, Potassium channel toxin beta-KTx 1, Tityustoxin K-beta, TsTX K beta, TsTX-K beta, Tityustoxin-8, Ts8, TsK2.
What is the protein family that this protein belongs to?
Belongs to the long chain scorpion toxin family. Class 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARY3_MOUSE
Sequence: MDIEAYFERIGYQKSSNKLDLQTLTEILQHQIRAIPFENLNIHCGKTMELSLEDTFHQIVRKKRGGWCLQVNHLLYWALAMIGFETTMLGGCVYVPSACKYSNTMIHLLLQVTISGKTYIVDSAFPFSCQLWEPLELTSGKDQPQVPAIFHLREENGTWYLEQTKRQEYVSNQEFIDSNFLEKNTHRKIYSFTLEPRTIEDFWSISTYYQVSRTSVMTNTSLCSLHTKDGVHGLMGTILAYKKFNYKDNIDLVEFKTLKEEEIEEVLKSVFGIHLETKLVPKCGNVFFTI
What is the function of this protein?
Participates in the detoxification of a plethora of hydrazine and arylamine drugs.
What are the official names of this protein?
Arylamine N-acetyltransferase 3, Arylamide acetylase 3, N-acetyltransferase type 3, NAT-3.
What is the protein family that this protein belongs to?
Belongs to the arylamine N-acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_DEHM1
Sequence: MPPFRAVILFRHMEINVIVKPPFKKLVSTPFLKKIASKTLKAQAADPNSELGIVITGQEEIKDLNLKYRGLDEPTDVLSFYMLEENPENLTAADDFPTPPDENIHLGEVIISYPQAELQATAASHSVSHEIAFLLIHGVLHLLGYDHHEVVAEAVMKSHQDIAMKHIREILE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_PROMH
Sequence: MPLLDSFTVDHTRMSAPAVRVAKTMKTPSGDTITVFDLRFTVPNKKAMPEKGIHTLEHLFAGFMRNHLNGEGVEIIDISPMGCRTGFYMSLIGQPDEQRVANAWKAAMEDVLKVKDQNHIPELNVYQCGTYEMHSLAEAQDIARDILSHTIGINHNDELALPEDKLKELQI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: PHYK3_SOYBN
Sequence: MMFLSFNMISGGNTLQRFDPVACVSSVPLLLAPTTRPTFHFPSPFLSKPKPTYLFTSFSSSSSSSSSFFSSTTPPRSTMLHHDPLVSDVYATAISGVVALSFLRLFQETAKRDLFDQKLNRKLVHISIGLIFMLCXPLFSTETWASFFAALIPGINIFRMLVIGLGILKDEATVKSMSRFGDYRELLKGPLYYAATITLAAIIYWRTSPISIAAICNLCAGDGMADIVGRRLGGEKIPYNKNKSFAGSIAMATAGFLTSIGYMWYFSSFGFIEGSWKLVLGFLLVSIVTAFVESLPISTELDDNLTVPLTSILVGSIIL
What is the function of this protein?
Involved in the activation and reutilization of phytol from chlorophyll degradation in plant metabolism, including tocopherol biosynthesis.  Catalyzes the conversion of phytol to phytol monophosphate (PMP) (By similarity).
What are the official names of this protein?
Probable phytol kinase 3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the polyprenol kinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: MERTK_MOUSE
Sequence: MVLAPLLLGLLLLPALWSGGTAEKWEETELDQLFSGPLPGRLPVNHRPFSAPHSSRDQLPPPQTGRSHPAHTAAPQVTSTASKLLPPVAFNHTIGHIVLSEHKNVKFNCSINIPNTYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSIASVQRSDNGSYFCKMKVNNREIVSDPIYVEVQGLPYFIKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEKPERSPSVLTVPGLTETAVFSCEAHNDKGLTVSKGVHINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADRLSNGSVMVFNTSASPHLYEIQQLQALANYSIAVSCRNEIGWSAVSPWILASTTEGAPSVAPLNITVFLNESNNILDIRWTKPPIKRQDGELVGYRISHVWESAGTYKELSEEVSQNGSWAQIPVQIHNATCTVRIAAITKGGIGPFSEPVNIIIPEHSKVDYAPSSTPAPGNTDSMFIILGCFCGFILIGLILCISLALRRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSEELQNKLEDVVIDRNLLVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRLNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEITTRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRLQLEKLSESLPDAQDKESIIYINTQLLESCEGIANGPSLTGLDMNIDPDSIIASCTPGAAVSVVTAEVHENNLREERYILNGGNEEWEDVSSTPFAAVTPEKDGVLPEDRLTKNGVSWSHHSTLPLGSPSPDELLFVDDSLEDSEVLM
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6.  Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis).  Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1.  MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment.  Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis.  Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
What are the official names of this protein?
Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PYRE_THET8
Sequence: MDVLELYRRTGALLEGHFLLRSGMHSPFFLQSAALLQHPLYAEAVGEALGKLFKDEKVDFVIAPAIGGVVLSFVVAKALGARALFAEKDGRGGMLIRKGLTVNPGDRFLAVEDVVTTGESVRKAIRAAEARGGVLVGVGAIVDRSGGRAAFGVPFRALLALEVPHYPEEACPLCREGVPLEEV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: EFG_RHIWR
Sequence: MARSHPLEKYRNIGIMAHIDAGKTTTTERILYYTGKSYKIGEVHEGTATMDWMEQEQERGITITSAATTCFWNDHRINIIDTPGHVDFTIEVERSLRVLDGAVTAFDGVAGVEPQSETVWRQADKYRVPRMCYVNKLDRTGANFQRCVQMIKDRLGARPAVLYLPIGIESSFVGLVDLVENRAIVWLEESLGAKFEYRDIPDDMKDEAAVARQELIELAVEQDEAAMESYLEGNEPDVATLKALLRKGTLAFDFVPVLCGSSFKNKGVQPLLDAVVDYLPSPLDIPDVQGVKLDGETPDSRPAEDSAPMSALAFKIMNDPFVGSLTFARIYSGKLEKGTYLNSVKDKKEKIGRMLLMHANSREDIEEAYAGDIVALAGLKETTTGDTLCAPSAPIILERMEFPDPVIELSVEPKTKADQEKMGIALNRLAAEDPSFRVSSDHESGQTIIKGMGELHLEILVDRMKREFKVEANVGAPQVAYREYLKKPVELVYTHKKQSGGSGQFGEVKVQVKPGERGSGFVFVDEVKGGNIPREYIPSVEKGMRETAEGGSLIGFPIVDVEVHLIDGKYHDVDSSALAFEITGRGAMREAAQKAGITILEPIMKVEVVTPEDYLGDVIGDMNSRRGQIQGTDSRGNAQVVEAMVPLANMFGYVNQLRSFTQGRAQYSMQFSHYDEVPANVADEVKAKLA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPEP_AEDAE
Sequence: MWKFASIVVLVVCLAWAVYCEDQRPPSLKTRFGRSADEPESDNYVSNDIMEKRSAQRPPSLKTRFGRSEGAEVMEKRSAQRPPSLKTRFGRSVANPESDGYMRKRSAESEPFVTRIRHGRANKKRAAN
What is the function of this protein?
Has a role in inhibiting host-seeking behavior during a reproductive cycle.
What are the official names of this protein?
Head peptide, Aea-HP, AeaHP.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: DPOD2_RAT
Sequence: MFSEQAAQRAHTLLSPPSASNATFARVPVATYTNSSQPFRLGERSFNRQYAHIYATRLIQMRPFLVSRAQQHWGSQVEVKKLCELQPGEQCCVVGTLFKAMPLQPSILREISEEHNLIPQPPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLAVFGSVKDDGKFQVEDHCFADLAPQNPVPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDVVTGQLGDEGEQCSAAHVSRVILAGNLLSHNTQSRDSINKAKYLTKKTQAASVEAVKMLDEILLQLSASVPVDVMPGEFDPTNYTLPQQPLHPCMFPLATAYATLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMEDHLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFAECPHVYFCGNTPSFGSKVIRGPEDQAVLLVAVPDFSSTQTACLVNLRGLTCQPISFAGFGAEQDDLEDLGLGP
What is the function of this protein?
Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex.  As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair.  Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4.  They exhibit differences in catalytic activity.  Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4.  Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides.  Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated.  Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation.  Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR).  Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH).  Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion.  Also involved in TLS as a component of the DNA polymerase zeta complex.  Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7.
What are the official names of this protein?
DNA polymerase delta subunit 2, DNA polymerase delta subunit p50.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase delta/II small subunit family.
What are the subcellular locations of this protein?
Nucleus. Note=Recruited to DNA damage sites within 2 hours following UV irradiation.
Protein: PTGIS_BOVIN
Sequence: MSWAVVFGLLAALLLLLLLTRRRTRRPGEPPLDLGSIPWLGHALEFGKDAAGFLTRMKEKHGDIFTVLVGGRHVTVLLDPHSYDAVVWEPRSRLDFHAYAVFLMERIFDVQLPHYNPGDEKSKMKPTLLHKELQALTDAMYTNLRTVLLGDTVEAGSGWHEMGLLEFSYGFLLRAGYLTQYGVEAPPHTQESQAQDRVHSADVFHTFRQLDLLLPKLARGSLSAGDKDRVGKVKGRLWKLLSPTRLASRAHRSRWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELETVLLGAEQPISQMTTLPQKVLDSMPVLDSVLSESLRLTAAPFITREVVADLALPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYSLPWGAGHNQCLGKGYAVNSIKQFVFLVLTQFDLELITPDVDIPEFDLSRYGFGLMQPEHDVPVRYRIRP
What is the function of this protein?
Catalyzes the biosynthesis and metabolism of eicosanoids.  Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:8051072, PubMed:8280118).  Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (By similarity).
What are the official names of this protein?
Prostacyclin synthase, Hydroperoxy icosatetraenoate dehydratase, Prostaglandin I2 synthase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.