PharMolix/UniProtQA huggingface dataset:
Protein: CSCL5_ARATH
Sequence: MATLKDIGVSAGINILTAFIFFIIFAFLRLQPFNDRVYFSKWYLRGLRSSPASGGGFAGRFVNLELRSYLKFLHWMPEALKMPERELIDHAGLDSVVYLRIYWLGLKIFAPIAMLAWAVLVPVNWTNNELELAKHFKNVTSSDIDKLTISNIPEGSNRFWAHIIMAYAFTIWTCYMLMKEYETVANMRLQFLASEGRRPDQFTVLVRNVPPDPDETVSELVEHFFLVNHPDNYLTHQVVCNANKLADLVSKKTKLQNWLDYYQLKYTRNNSQIRPITKLGCLGLCGQKVDAIEHYIAEVDKTSKEIAEERENVVNDQKSVMPASFVSFKTRWAAAVCAQTTQTRNPTEWLTEWAAEPRDIYWPNLAIPYVSLTVRRLVMNVAFFFLTFFFIIPIAFVQSLATIEGIEKVAPFLKVIIEKDFIKSLIQGLLAGIALKLFLIFLPAILMTMSKFEGFTSVSFLERRSASRYYIFNLVNVFLGSVIAGAAFEQLNSFLNQSPNQIPKTIGMAIPMKATFFITYIMVDGWAGVAGEILMLKPLIIYHLKNAFLVKTEKDREEAMNPGSIGFNTGEPQIQLYFLLGLVYAPVTPMLLPFILVFFALAYVVYRHQIINVYNQEYESAAAFWPDVHGRVITALIISQLLLMGLLGTKHAASAAPFLIALPVITIGFHRFCKGRFEPAFVRYPLQEAMMKDTLERAREPNLNLKGYLQDAYIHPVFKGGDNDDDGDMIGKLENEVIIVPTKRQSRRNTPAPSRISGESSPSLAVINGKEV
What is the function of this protein?
Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions (PubMed:25162526, PubMed:30190597).  Shows the following permeability sequence: K(+) > Ba(2+) = Ca(2+) > Na(+) = Mg(2+) = Cs(+) (PubMed:25162526).  Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions (PubMed:30190597).
What are the official names of this protein?
Protein OSCA1, CSC1-like protein At4g04340, Hyperosmolality-gated Ca2+ permeable channel 1.1, AtOSCA1.1, Protein reduced hyperosmolality-induced [Ca(2+)]i increase 1.
What is the protein family that this protein belongs to?
Belongs to the CSC1 (TC 1.A.17) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUVB_BACAH
Sequence: MSIMDERLLSGESAYEDADLEYSLRPQTLRQYIGQDKAKHNLEVFIEAAKMREETLDHVLLYGPPGLGKTTLANIIANEMGVNVRTTSGPAIERPGDLAAVLTSLQPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATTRAGALSAPLRDRFGVLSRLEYYTVDQLSAIVERTGEVFEVEINSLAALEIARRARGTPRIANRLLRRVRDFAQVRGNGTVTMEITQMALELLQVDKLGLDHIDHKLLLGIIEKFRGGPVGLETVSATIGEESHTIEDVYEPYLLQIGFLQRTPRGRIVTPLAYEHFGMEMPKV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: VSPSA_GLOBR
Sequence: MVLIRVLVNFLILQLSYAQKSSELVIGGDECNINEHRFLALLYSERFQCGGTLINEEWVLTAAHCDMRNMYIYLGVHNVSVQYDDEQRRYPKKKYFRLSSRNYNQWDKDIMLIRLNRPLRNSAHIAPLSLPSNPPSVGSVCRIMGWGTITSPQVTFPDVLHCANINIFDYEVCRAAYPELPATRRTLCAGILEGGKDSCNGDSGGPLICNGQFQGIAYWGADTCAQPREPGLYTKVFDYIDWIQSIIAGNTAVTCPP
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine protease salmonase, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LIN54_HUMAN
Sequence: MEVVPAEVNSLLPEEIMDTGITLVDDDSIEAVIVSSPIPMETELEEIVNINSTGDSTATPISTEPITVYSNHTNQVAVNTTITKADSNTTVKPAFPSGLQKLGAQTPVTISANQIILNKVSQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQLPQAQKVTTQAQSGDAKLPPQQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSVLQTQQLKTVQIAKKPRTPTSGPVITKLIFAKPINSKAVTGQTTQVSPPVIAGRVLSQSTPGTPSKTITISESGVIGSTLNSTTQTPNKIAISPLKSPNKAVKSTVQTITVGGVSTSQFKTIIPLATAPNVQQIQVPGSKFHYVRLVTATSASSSTQPVSQNPSTNTQPLQQAKPVVVNTTPVRMSVPIVSAQAVKQVVPKPINPTSQIVTTSQPQQRLIMPATPLPQIQPNLTNLPPGTVLAPAPGTGNVGYAVLPAQYVTQLQQSSYVSIASNSTFTGTSGIQTQARLPFNGIIPSESASRPRKPCNCTKSLCLKLYCDCFANGEFCNNCNCTNCYNNLEHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCNCKRSGCLKNYCECYEAKIMCSSICKCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSSQISDLLTRPTPALNSGGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAERMILEEFGRCLMSVINSAGKAKSDPCAMNC
What is the function of this protein?
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812).  In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812).  In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812).  In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879).  Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).
What are the official names of this protein?
Protein lin-54 homolog, CXC domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the lin-54 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIDC2_STRPN
Sequence: MKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKLVYFFAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQMVASRKMQEAQPRIKALREQYPGRDMESRTKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGHFLWINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAPGGVALYWTVSNAYQVLQTYFLNNPFKIIAEREAVVQAQKDLENRKRKAKKKAQKTK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC 2, Foldase YidC 2, Membrane integrase YidC 2, Membrane protein YidC 2.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SIGA_MYCPN
Sequence: MSSPKKNFKKPQPKTENQKQALNEERIAELKKSRILGKNRPFKKMIYVDTKAQRKQKHENVAFLKTLQENKESDVPKKRRGRKPKHAPLKEKNNLKLFDILEGSLKSHTENDDTNKVISLLVEVWEKKNKKKDNNSLSNKDIVNVLSKFELPDDEIIFVLDELRDKGIELPHDVEEHIHEFRANQDLSIIDEDIEELTTKNISNRDKVDDNVRFFLGSLDSSKMLDFESEQRIAKVLNSTDEESRKYAINQLVTSNLRLVVSIAKKHLERGLDFNDLIQEGNLGLLKAISKFNWSLGNKFSTYATWWIKQAITRAIADQARTVRIPVHMVETINRLAKAERALNQELGREPTAEELAEKMGGQAEGFTVKKIAEIKRLSLDPVSLDKTVGHDEESQFGDFVRDTDAQMPDEFTESRSNYEKIDELLNNCLSEQEELIVRMRIGMPPYNETKTLDEVSQKIKIPREKIRQIETKAIRKLRQAVRNNHMSLSFMRGNEKKD
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA, Sigma-A.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPSB_STRPC
Sequence: MTSIIYSPKDIFEQEFKTSMRGFDKKEVDEFLDNVIKDYENFNAQIEALKAENEALKKAKFQARNTVSATVQQPVPQPTRVAQSATNFDILKRISKLEKEVFGKQIIE
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: SEC16_ASPCL
Sequence: MTQVEGLSTWNPAFRPEDNESIITNNLAQLVLDPESRPAEVSPVDVHTSPFGDDADVENETHVLESPLPSEPQDAPAPVATDSDPSQNADPITELKDVLEQPRHIDGNDSSIHPDDTQVAENVAEYVSTQPEDDKEQANGLHLGNTVAEGMSAEHDKDEHTSGLHLGNSVAEASHFSAPEEFSGVETSGNGLHFRAVKGDTSWIDGDEVEEDKDAMPHGEISNDRPGFWGNLGNDGRDNEDDFFDQLKTQTKPIYVPPETESRFEEGVPLLDNSPQTPVEQAQRGDNQLDNVFAGDEDDEGDFFNEIQKSTPEEGPFHITRKSTTQVLSTLDTTPDSPFSETSPTAQDFNQILADTSAQNETKEPSDADLAARWQAELSDDAEETMPPEDDLAARWQAELDDDDDDLLLDEASTANNDQEAAQLNQDHNAGFAASLQSPFGTPENPARPKAQPISYTPHQPSTSDLLQGIPAQAPVPQPHNAPTSNYFTAQAPPNPVTTRAESFAERSKEGYKSPYDLPEDLARPRRPVVSKQVIPQPGNLPPPPPRSSSIPAPSPQPSKAPAGVLGTSPKQPVAAVTPKNFYEELPLPPPRPKSRPASSGRYTPNPTSAPPPAPLSVPQSIPAPANPYASIPLAPKSAGDLQSPPELHQPEKLDPYSSLLAPAALGAPVVPGAQSRYSPKPPGLQAGTKPLPSPRYSPAPPASTVVAGAPPPRNRYASQPSSISGPGAVLPFQPRTSSPLAHHEKISYHPPGVSEERRRSEPAAGLPPPSHAQPFQPPVIPESQGPVDAGIHENVQPSVTQPNSPPRNPYAPSAYVNEFAKRVAPVQNDLPSIGTQNVAYAPPVGESPFVPPRRSQTQSPSQQLLSPRLSLPPIDPLQRPASVHGATSPTKTVNPYAPAQVSLHNRALSQSLDFIPPTDGQQLDPLERWKGAPIVKFGFGGIVTSCFPKHIPRYSAGQAAPMIKSCPGEIKICPLNDRLPPAESIVQYPGPLKNKSKKKDLLAWLSSKIAAFENEGDPSFDPTQPDITKRHEEKILLWKIVRFLVEHDGALEGSAEAQKSLRSVMFPHLQQSTTDQVPGDSFIPAATPQAIDASARSDAADSHSIESLRDSLVLGEREKAVWAAVDNRLWGHAMIIASTMDRSVWKQVVQEFVRREVRSTTSRTESLAAFYEILAGNVEESIDELVPPSARAGLQMISKVDGQGPAKNTLDGLESWRETLGLVLSNRSPDDQRALLALGQLLLSYGRTEAAHICFIVSRAAVFGGIDDPQANIVLLGVDHHRLASSAPLHNDDSILLTEAYEYATSVLAGSPMNTLPYLLAFKLIHAWSLADQGRKSEAQQYCDAIAAALKAATKPSGYHNPHLFYGVDELSARLRQTASDAGSSWITRPSMEKVSGSMWAKFNSFVAGEESDAASTGSGKAEEIGPFAKVSGTPTVSRSPSVSDIYGSYPMGGAQSAPNTGASRYHPVNQYALSSSPEQLRGRSSLDSQRSSSYGFPPPQRRGSQEPSTPVEMNIYQGMPTYGSPSAAGYQSTPPQTSYMPLAPVEEDSAAYSPPDPQPAPSQTLDNVSPYQPAHYAPESFGQPFETNDASATSQFEQGGYMPPSSGGGYEPPFVEVNPASASDDVEDESNEGAKPKKKSFMDEDDDDDMAARAAAIQKAERARRDREADEAFRKAAEADAQKPPPTTAKKGWFTGWFGGKKEENNSGGGPIRAKLGEENSFYYDKELKKWVNKKDPGSSTPARGTPPPPRGSAPPSRTASGTGGPPPPAVGTPPLAALGAGSRPSSSAGVPPRLTSSPAPSALGAPPPIPRSVSTSATLPTPPDGSAGAPPRPATSLSYASSIDDLLGAPQARKGPAARGKKKGRYVDVMAK
What is the function of this protein?
Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules.  Also involved in autophagy (By similarity).
What are the official names of this protein?
COPII coat assembly protein sec16, Protein transport protein sec16.
What is the protein family that this protein belongs to?
Belongs to the SEC16 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MSRA_NATPD
Sequence: MTATATLGGGCFWCVEAAFEELDGVESVTSGYAGGHTEDPTYREVCSGNTGHAEVVQVAYDSDVLAYEDLLEVFFTVHDPTQLNRQGPDVGSQYRSIVLYHDDTQRELAEAYIESLDEAGEYDDDIVTEIERLETFYRAEENHQNYFEKNPQDAYCRMHAQPKIETVREAFAEKVDSR
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: RL3_GLAP5
Sequence: MIGLVGRKVGMTRIFNEDGVSIPVTVIEIEANRVTQVKTLENDGYTAVQVTTGSKKASRVTKPEAGHFVKAGVEAGRGLWEFRTEGEEFTLGQEINVDIFTDVKKVDVTGTSKGKGFQGGVKRWNFRTQDATHGNSLSHRVLGSIGQNQTPGRVFKGKKMAGHLGAERVTVQSLEVVRVDAERKLLLVKGSVPGATNSDVIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PEPB_ECOLI
Sequence: MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVVWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNVAGDRVTYRITKGEDLREQGYMGLHTVGRGSERSPVLLALDYNPTGDKEAPVYACLVGKGITFDSGGYSIKQTAFMDSMKSDMGGAATVTGALAFAITRGLNKRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASAQKPEMIIDAATLTGAAKTALGNDYHALFSFDDALAGRLLASAAQENEPFWRLPLAEFHRSQLPSNFAELNNTGSAAYPAGASTAAGFLSHFVENYQQGWLHIDCSATYRKAPVEQWSAGATGLGVRTIANLLTA
What is the function of this protein?
Probably plays an important role in intracellular peptide degradation (PubMed:20067529).
What are the official names of this protein?
Peptidase B, Aminopeptidase B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO12_SULIN
Sequence: MAVYRCGKCWKTFTDEQLKVLPGVRCPYCGYKIIFMVRKPTIKIVKAI
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo12, DNA-directed RNA polymerase subunit P.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH2_LACPL
Sequence: MDKKQRKVVIVGDGSVGSSFAFSLVQNCALDELVIVDLVKTHAEGDVKDLEDVAAFTNATNIHTGEYADARDADIVVITAGVPRKPGESRLDLINRNTKILESIVKPVVASGFNGCFVISSNPVDILTSMTQRLSGFPRHRVIGTGTSLDTARLRVALAQKLNVATTAVDAAVLGEHGDSSIVNFDEIMINAQPLKTVTTVDDQFKAEIEQAVRGKGGQIISQKGATFYGVAVSLMQICRAILNDENAELIVSAALSGQYGINDLYLGSPAIINRNGLQKVIEAELSDDERARMQHFAAKMLTMMNVAS
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase 2, L-LDH 2.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_GLAP5
Sequence: MAKLHDYYRDTVVNELKAKFNYSSVMQVPRIEKITLNMGVGEALTDKKLLDNAVADLTAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLNAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKTDEEGQALLAAFNFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: CHO2_YEAS2
Sequence: MSSCKTTLSEMVGSVTKDRGTINVKARTRSSNVTFKPPVTHDMVRSLFDPTLKKSLLEKCIALAIISNFFICYWVFQRFGLQFTKYFFLVQYLFWRIAYNLGIGLVLHYQSHYETLTNCAKTHAIFSKIPHNKDANSNFSTNSNSFSEKFWNFIRKFCQYEIRSKMPKEYDLFAYPEEINVWLIFRQFVDLILMQDFVTYIIYVYLSIPYSWVQIFNWRSLLGVILILFNIWVKLDAHRVVKDYAWYWGDFFFLEESELIFDGVFNISPHPMYSIGYLGYYGLSLICNDYKVLLVSVFGHYSQFLFLKYVENPHIERTYGDGTDSDSQMNSRIDDLISKENYDYSRPLINMGLSFNNFNKLRFTDYFTIGTVAALMLGAIMNARFINLNYLFITVFVTKLVSWLFISTILYKQSQSKWFTRLFLENGYTQVYSYEQWQFIYNYYLVLTYTLMIIYTGLQIWSNFSNINNSQLIFGLILVALQTWCDKETRLAISDFGWFYGDFFLSNYISTRKLTSQGIYRYLNHPEAVLGVVGVWGTVLMTNFAVTNIILAVLWTLTNFILVKFIETPHVNKIYGKTKRVSGVGKTLLGLKPLRQVSDIVNRIENIIIKSLVDESKNSNGGAELLPKNYQDNKEWNILIQEAMDSVATRLSPYCELKIENEQIETNFVLPTPVTLNWKMPIELYNGDDWIGLYKVIDTRADREKTRVGSGGHWSATSKDSYMNHGLRHKESVTEIKATEKYVQGKVTFDTSLLYFENGIYEFRYHSGNSHKVLLISTPFEISLPVLNTTTPELFEKDLTEFLTKVNVLKDGKFRPLGNKFFGMDSLKQLIKNSIGVELSSEYMRRVNGDAHVISHRAWDIKQTLDSLA
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CRYAB_MACFA
Sequence: MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRVPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
What is the function of this protein?
May contribute to the transparency and refractive index of the lens.  Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.  In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).
What are the official names of this protein?
Alpha-crystallin B chain, Alpha(B)-crystallin.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Lysosome. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Localizes at the Z-bands and the intercalated disk in cardiomyocytes. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: CHMD_STRBI
Sequence: MTADRWAGRTVLVTGALGFIGSHFVRQLEARGAEVLALYRTERPQLQAELAALDRVRLIRTELRDESDVRGAFKYLAPSIDTVVHCAAMDGNAQFKLERSAEILDSNQRTISHLLNCVRDFGVGEAVVMSSSELYCAPPTAAAHEDDDFRRSMRYTDNGYVLSKTYGEILARLHREQFGTNVFLVRPGNVYGPGDGYDPSRGRVIPSMLAKADAGEEIEIWGDGSQTRSFIHVTDLVRASLRLLETGKYPEMNVAGAEQVSILELARMVMAVLGRPERIRLDPGRPVGAPSRLLDLTRMSEVIDFEPQPLRTGLEETARWFRHHTR
What is the function of this protein?
Catalyzes the stereospecific reduction of the C-4 keto group of dTDP-4-dehydro-6-deoxy-D-allose, leading to dTDP-6-deoxy-D-allose, an intermediate in the biosynthesis of the mycinose moiety of the chalcomycin antibiotic.
What are the official names of this protein?
dTDP-4-dehydro-6-deoxy-D-allose reductase, dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase, dTDP-4-keto-6-deoxyallose reductase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: RIMP_THEVB
Sequence: MQIQMLLPLVQTLAQQVADQEHLDLVSVQWLTHQSPPILRVEVRHPENDTSLEDCERLSRALEMALDELPEFEFAYVLEVSSPGLSDYLSSDRDFDAFRGFPVRVTTTAPHRGKTLWEGNLIRRDEVNVYLNQRGRSLAIPRSLIASVQLYTPSSEP
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_BETPA
Sequence: MEEFQGYLELDRFRQHDFLYPLIFREYIYALAHDHGLNRVILLENVTYDNKSSLLIVKRLITRMYQQNHLMISANDSNQNKFLGYNKNLYSQIISEGFAIIAEIPFSLRLIFSLEGSQIVRSYNLRSIHSIFPFLEDKFPHLNYVADVLIPYPIHLEILVQTLRYRVKDASSLHLLRFFLHEYSNGNILIILNKSISIFSKSNSRLLLFLYNSYICEYESVFLFLRNQSNHLRLTSSGVLFERIYLHRKMEDLVEVFVNDFQGILCFLKDPFIHYVRYQGKSILASKDTPLLMNKWKYYLVSLWQCHFFVWSRPGRIYINQLSKHSLDFLGYFSSVPLNPSMVRSQMLENSFIINNAPKKLDTIVTIIPLIGSLAKAKFCNALGHPISKPTWADLSDFDIINRFVRICKNLSHYYSGSSKKKGMYRIKYILRLSCVKTLARKHKSTIRAFLKRLGSELFEEFFTEEEEFLSLIFPRTSFTLRRLYRGRVWYLDIICMNGLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LEPA_CLOBH
Sequence: MQSERQKYIRNFSIVAHIDHGKSTLADRLIEATGTLTEREMDTQVLDNMDLEKERGITIKSQAVRLIYKRDTGEEYTLNLIDTPGHVDFNYEVSRSLAACEGAILVVDATQGIQAQTLANCYLALDNDLEIVPVINKIDLPSARPEEVKQEIEDVIGIEAEDAPLVSAKTGLNIKDALEAIVNKVPAPDGDEKAPLKALIFDSYYDSYKGVVCHIRVKEGAIKEGTEIKLMNTGKVYEVVEVGVFVPNYMPVDELKAGDVGYVTASIKNVRDARVGDTITEAKRSANEALSGYRPAVPMVFSGIYPVDGAKYEELKEALEKLQVNDAALSFEPETSIALGFGFRCGFLGLLHMDIIQERLEREFNLDIITTAPSVIYKITKTDGTLIELTNPTNMPSPSEIKLMEEPIVKSSIITPSDYVGAVMDLAQNRRGIFKDMQYLDTTRVSLNYEIPLNEIIYDFFDALKSRTRGYASFDYELIGYKDADLVKLDILLNADVVDALSMIVPRERAYAKGRNMAQKLKEIIPRQMFEIPIQAAVGAKIIARETIKAMRKDVLAKCYGGDISRKRKLLEKQKEGKKRMRQVGSVEVPQEAFMAVLKTEE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PANB_SULDN
Sequence: MAKKMTITSIKKSKGVHPLVMITAYDALFARLLEPSADMILVGDSLNMSFAGRDDTLSATLSQMIYHTNAVAKGAKNSFIICDMPFGTYTNRDDALKNSIKVFQESSADALKIEGGEDKAEIISHLCSNGIAVCGHIGLLPQAFRSEGGYKVKGKTDEERIQLIRDAKAIEKAGAFCMVIEGVKADVAAQVAASVKIPVIGIGAGRDVDGQVLVFSDMLGLFEEFTPKFVKKYLDGASLVKEALKSYADEVKTRAFPQDIHTY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_CLOPS
Sequence: MKKIGVFGGTFDPIHIGHIYIAYEAYKILELDEVIFMPAGNPPHKKWKDITDEIIRYEMVKKAIEPYSFFSINNYEIEKKGLSFTYETLRYLHESFKEVELYFITGADCLVNLNSWKNINEIFKFSNLVVFNRPGFDKNNLLKRKEEFDREYCTNIVYLDLLNIEISSTLIRERVRQSLEVKFFLPPGVVDIIDKYNLYRRE
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.