PharMolix/UniProtQA huggingface dataset:
Protein: ATG3_ASPOR
Sequence: MNILHSTLSTWRDRLAPVSRTSTFRNTGQITPEEFVLAGDYLVYKFPSWSWADASNPAKRVSYLPPGKQFLVTRGVPCHRRLNDNFAGDAGHDDELVRDMLSGGTGGVDDDGWLRTGGGQDSADRQENRIKDVRTVDESGNMGEREEEEDEIPDMEDEDDDEEAIIRDPASGTTQPTRTYNLYITYSNFYRTPRLYMSGYLSPSEPLPPHLMMEDVVGDYKDKTVTLEDFPWYDGNVKMASVHPCRHASVMKTLLDRADAALKLRREKLKQAQSDPSKAPSVGESGLEGLVDDIKALSLSDQQQHGSDKSGGDEWEVLQHDEEEQVAIRVDQYLVVFLKFIASVTPGIEHDFTMGV
What is the function of this protein?
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8.  The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE).  This step is required for the membrane association of atg8.  The formation of the atg8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).  The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 3, Autophagy-related E2-like conjugation enzyme atg3.
What is the protein family that this protein belongs to?
Belongs to the ATG3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPE_ECOSE
Sequence: MSCPVIELTQQLIRRPSLSPDDAGCQALLIERLQAIGFTVERMDFADTQNFWAWRGQGETLAFAGHTDVVPPGDADRWINPPFEPTIRDGMLFGRGAADMKGSLAAMVVAAERFVAQHPNHTGRLAFLITSDEEASAHNGTVKVVEALMSRNERLDYCLVGEPSSIEVVGDVVKNGRRGSLTCNLTIHGVQGHVAYPHLADNPVHRAAPFLNELVAIEWDQGNEFFPATSMQIANIQAGTGSNNVIPGELFVQFNFRFSTELTDEMIKAQVLALLEKHQLRYTVDWWLSGQPFLTARGKLVDAVVNAVEHYNEIKPQLLTTGGTSDGRFIARMGAQVVELGPVNATIHKINECVNAADLQLLARMYQRIMEQLVA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: Y742_NEIG1
Sequence: MFGKAGLGGLMKQAQQMQENMKKAQAKLAETEIEGEAGNGLVKITMTCAHEVRKIDISPDLIQEAADDKEMLEDLILAALKSARGKAEETANKTMGAFTQDLPPGVGDFFR
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein NGO0742.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: POTA_MYCGA
Sequence: MEDKVFIQLRNVNKTFDDGFVAVRNLNLDINKSEFVTLLGPSGCGKTTTLKLLAGFEQPTYGQIKINGIDIKDMPVHKRPFATVFQDYALFPNMTVYNNVCYGLKIMRVPKENTDPKLAVEAENIKKEAEKKAAAKIKDLSRKKNDLSNKLDKIRKEYEKNDWMLENDEMRFAQYQEELIKLEAQLSEAYEQSEINKLNQEIVELKTNYQKKIPIDNRYDKVLKELENADGWTSYWETYPIMKKEHFENKVLTRRLTKKEIEERANNMIKLVGLTGKEDKYPSELSGGMQQRVALARALVIEPETLLLDEPLSALDAKVRKQLQNELKRIHKELNITFILVTHDQEEALSLSDKIVVMSQGDIEQVGKPNAIYDSPINEWTAKFIGAANIFDGKYLGDYKIELNSGDIIDTDEEYEFKKGDNVRVLIRPEDFDVVEKDQGFFNVEVIKTSYKGVLWEVECLMSDKTKIKVDNIDEVKVGAIVGLKFDEMDVHMMRKEEEDV
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TAT_HV1OY
Sequence: MEPVDPRLEPWKHPGSQPKTASNNCYCKRCCLHCQVCFTKKGLGISYGRKKRRQRRRAPQDSKTHQVSLSKQPASQPRGDPTGPKESKKKVERETETDPED
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: RF1_OCEIH
Sequence: MLDRLQSLEDRYNKLNEMLSDPEVINDSKKLREYSKEQSGLEDVVQAYREYKEVTEQLNDAKEMMEDKLDDEMYEMVKAEIAELNGRKEELESSMKILLLPKDPNDDKNVFMEIRGAAGGDEAALFAGDLYRMYSRYAEHQGWKIDVMEASSTGVGGYKEVIFMINGSDVYSKLKYENGAHRVQRVPETESGGRIHTSTATVAVLPEAEEVEVEVHDKDIRVDTFASSGPGGQSVNTTMSAVRLTHVPTGIVVSIQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDENRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQIMQGKLDEFIDALVMEEQTNKLEQIGE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_CERS1
Sequence: MAEQQKGLTYADAGVDIDAGNALVERIKPAAKRTARPGTVSGLGGFGALFDLKAAGYHDPVLVAATDGVGTKLRIAIDTGEVDTIGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLEVAQAARIIEGIAEGCAASGCALIGGETAEMPGMYHKGDFDLAGFAVGAMERGADLPQGVAEGDVLLGLGSNGVHSNGYSFVRKVVELSGLGWDAPAPFGGDSLGRALLAPTRLYVKQALAAVRAGGVHALAHITGGGLTENLPRVLPEGLGARIDLSAWELPPVFRWLAETASMAEPELLKTFNCGIGMIVVVAADRADEIAALLAAEGETVTRIGEVIAGEGVSYDGRLL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KBTB8_XENTR
Sequence: MAQTPSSTASTEVAKYVQTQNGIPPSNPVSSAMDPYHACSILQQLKAMYDEGKLTDIVVQVDHGKHFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRLVGIEAESMQLVLNYAYTSRVQLTEANVQALFTAASIFQIPSLQDQCAQYMISRLEPQNCIGVFSFADHYGHQELKEKAQDYIRKKFLYVTKEQEFLHLRKDQLISILNSDDLDVEKEEHVYDSIISWYEHEQETREMHLPEIFAKCIRMPLMEETFVEQIPPIFAQAMPINRVQKGKISANCCTRRLGMTASEMIICFEAANKHSGKKQTVPCLDTLTGKVYKLCKPPGDLREVGILVTPDNELYIAGGYRPSNNDVCIDHKAESDFWLYDHSSNRWLPKAPLLRARIGCKLVHCCGKLYAIGGRVYEGDGRNPLKSVECYDTRDNCWTAVSLMPVAMEFHSAVEYKDKIYILQGEVFLCYDPPRDYWCYLTPMTAPRVQGMAAVYKDSIYYVAGIRGNHRVLTVEAYDVEQNRWTRKKDLPCEQSSNPYIKLVVFKSKLHLFVRATQVSVEEFVFRTSRKNSLYQYDEIADSWKKVYETPERLWDLGRHFECAVAKLYPQCLQKVL
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832).  The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity).
What are the official names of this protein?
Kelch repeat and BTB domain-containing protein 8.
What is the protein family that this protein belongs to?
Belongs to the KBTBD8 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Translocates to the spindle apparatus during mitosis.
Protein: DDL_TOLAT
Sequence: MKHLHVLLLCGGGGSEHEISLLSANYLESQLKELAEVSVTRVELFPDHWQTNDGRSCHLGMDRQLHFANEAKPVDFVVPCIHGFPGETGDIQSMLELIGLPYLGCGSEGSKLCFNKVSTKLWLSALDIPNTPFLFLSDNNEAAHAQAHTAFRNWGAVFVKAASQGSSVGCYKVTDAAKLSEAVNAAFGYSDQVLVEKAVRPRELEVAVYRYNDQLVATRPGEIATPSDSFYSYEEKYSSGSNSTTYLEAPGLSDAQISTIREYALKAFTQLGLKDLSRIDFFLTEDNEILLNEINTFPGMTPISMFPKLLEHHGDNFKQFLEGIIRSTVK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_HALSA
Sequence: MASEKILGVDLGTTNSAFAVMEGSDPEIITNEEGDRTTPSIVAHDDGELLVGKPAKNQAVQNPDQTIASIKRHMGEEDYTVALGDDEYTPEEISARILQKIKRDAEEYLGQDVEKAVITVPAYFNDRQRQATKDAGEIAGFDVERIVNEPTAASMAYGLDEDRDQTVLVYDLGGGTFDVSILDLGGGVYEVAATNGDNDLGGDDWDHAIIDHLADNFENEHGIDLREDRQALQRLTEAAEEAKIELSSRKETTVNLPFVTATDSGPVHLEQDITRATFESITEDLIERTVGPTEQALEDAGLSKSDIDDVILVGGSTRMPQVQAQVEDLVGQEPKKNVNPDEAVALGAAVQGGVLSGEVDDIVLVDVTPLSLGIEVKGGLFERLIEKNTAIPTTASKVFTTAADNQTSVQIRVFQGEREIASENELLGDFHLTGIPPAPAGTPQIEVTFEIDADGIVNVEAEDQGSGNAESITIEGGAGLSDEQIDEMQEDAEAHAEEDEQRRRRIEARNEAETAIQRAESLLEENEELVDEDLEADVNDAIDDVQAVLDEDEPEIDALETATEELSDTLQEIGKQAYQQQQDAQAGAAGGAGGMGGMGGMADGPGGAADADGDDEEYVDADFEDVDEE
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: AROQ_EXISA
Sequence: MRILVLNGPNLNLLGRREPDVYGDVSLKGLAAELMLRAPEDVELTFKQSNHEGDLIDALHDAFDYEGVILNAGAYTHTSIAIRDAISAIAAPVVEVHISNVHARETFRHESKLAAVCIGVITGFGLTSYTLAMHALIEHWRNRHD
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: GCSH_PROMM
Sequence: MAFQFPDHFRFADTHEYASLDGELVRIGISAFAVDQLGDIVFVDLPEVGDRLNRGTTFGSVESVKAVEDLHAPISGELVRINESVLSSPDELQNDPHGEGWLLVVRPADPAQLQDLMDAATYANKVAIESSN
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: G3P_HALSA
Sequence: MIRVGINGYGTIGKRVADAVAAQPDMTVAGVAKTSPNFEATQARKRGFDLYTAVEDRADQFPAAGIETAGPVDDLIADSDVVVDATPSGVGAENRSRYAAHDTPAIYQGGEDASVADVSFNARANFEAAADADHVRVVSCNTTGLSRLLAPLREQYGIEKVRATLVRRGGDPGQTDRGPINDILPDPITIPSHHGPDVNTIFPDLDIDTLGMKVPATLMHMHSINVTLERDPDAADVRDVLAGQSRIMLLDDDLGIDGTGPLKEYAQDMGRPRGDLWENCLWGESVTMDGRDFYCFQAIHQESDVVPENVDAVRAIAGDADAAESIATTNDALGI
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCH_METAR
Sequence: MISINEISYSIVEEMLDFAEDYRIEPHTLANDSVVIDCGVKAKAGYEAGLLFTQVCMGGLAQTSLTHKKLKHEVFYPFIEVSTDFPAIACLAAQKAGWRISQDGYFAMGSGPARALALKPKHTYEVIEYEDDYDFAVIALEADKLPNEKVMDYIASECGVDSSDVVALVAPTNSPVGSVQIAGRVVEMAIYKLAELGFDTRHIVSAFGSAPIPPVKKDAAVAMGTTNDASIYHGSVTLTVDGGNIKDFVPKIPSSTSKDYGKPFYTVFKEAKFDFYKLDPGIFAPAEVVVNDISTGETYIAGKINADVCMESFGFKKL
What is the function of this protein?
Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
What are the official names of this protein?
Methenyltetrahydromethanopterin cyclohydrolase, Methenyl-H4MPT cyclohydrolase.
What is the protein family that this protein belongs to?
Belongs to the MCH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_STACT
Sequence: MIEVWPAIDLIDSTSVRLTEGDYETKEAMSRTAEEAIEFYSRYNCVTRIHVIDLIAAKQQTPLETNYIEQLVGLTQLPFEVGGGIRTLETIETYFDKGIQNVIIGTKGIQDPEWLKTVAEKYPGRIYISVDAYIDEIKVNGWLEDTGLNLFDYVQQIDSAPLGGIIYTDISKDGKLEGPNFELTAKLAASTKLPVIASGGIRSKEDLERLEKAGVAVAIVGKAANTQSFWEGLS
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_ACICJ
Sequence: MTKPQPVRGTQDIIGEDARRHHHVVETARRVAGLYGAAEWATPVFELTSVFARNLGETSDVVTKEMYTFEDRSGESVTLRPEGTAGVCRALVSNGLTQTLPQKIFYQGPMFRYERPQKGRYRQFHQIGLEIIGAAEPLADAEAIACGQQILDELGVGASITLHINTLGDRDSRDAYRTALVDYLSRYESELSDESKVRLVKNPLRILDTKDANDIRLLAEAPRIYDHLNPASAAFYDGLKAALSAFGIAFVENPRIVRGFDYYNHTAFEFVSTALGAQGTVLGGGRYDQLVEQMGGPPTPGVGWAAGIERLAMLLAATPATPRPVAVIPMGEAEQTAAIEILATLRRAGIAAEAAYRGNLKKRLERANRINARAAVLIGADELARGAVTLKTLDDGAQRELPRAELLAALG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACOR_BACSU
Sequence: MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPYLEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALDGHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCSAAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRFGERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGGTCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAARALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTLFLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIREDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNIRELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDMMIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES
What is the function of this protein?
Acts as a transcriptional activator of the acoABCL operon encoding the acetoin dehydrogenase complex.
What are the official names of this protein?
Acetoin dehydrogenase operon transcriptional activator AcoR.
Protein: RHA2B_ARATH
Sequence: MGLQGQLSDVSSDSIPLMLLALLATFFRHVRSLLLFPSSAPVVVVTSNLSVLADQLNLNRLFSYRYSDNAASDCIVCLSKLKTGEEVRKLDCRHVFHKQCLEGWLQHLNFNCPLCRSPLLPHHHQGHGSDASISAFPLRSTSTASSH
What is the function of this protein?
E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid (ABA) signaling and responses to salt and osmotic stresses during seed germination and early seedling development.  Acts additively with RHA2A in regulating ABA signaling and drought response.  Possesses E3 ubiquitin ligase activity in vitro.
What are the official names of this protein?
E3 ubiquitin-protein ligase RHA2B, RING-H2 finger A2b, RING-H2 zinc finger protein RHA2b, RING-type E3 ubiquitin transferase RHA2B.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SSRP_ECO57
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVLLRDGEAFLFGANITPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRVNREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDIKEREWQVDKARIMKNAHR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: LOLA_XANOM
Sequence: MHRQLRYAVLATALFASTAFAAARQELDTFTRGLKGLDGQFSQRVTDANGKVKENSSGRVALATPRQFRWEYAKPYRQLIVADGKKVWVFDPDLEQVTVRAQGSEEQNSPLVALINPALLDKKYDVSEEAAPRDGLQWLSLTPKVDTDASFQMASLGFGKDGLAKMEVVDAVGQRTTISFSGWKRNPAFAADTFRYTPAQGVDVVGDAH
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: APAG_ECOL5
Sequence: MINSPRVCIQVQSVYIEAQSSPDNERYVFAYTVTIRNLGRAPVQLLGRYWLITNGNGRETEVQGEGVVGVQPLIAPGEEYQYTSGAIIETPLGTMQGHYEMIDENGVPFSIDIPVFRLAVPTLIH
What are the official names of this protein?
Protein ApaG.
Protein: GLND_SINMW
Sequence: MARHETSFPEILDVAALRARCDFIASAHAEQREPMRRALLAAFKEANIAGRAKARELLAADGAGIKCAERISWLQDQLITLLHDFVLNQVFDAAKAPETSRIAVTAVGGYGRGTLAPGSDIDLLFLLPAKKAVWAEPAIEFMLYILWDLGFKVGHATRTIEDCIRLSRADMTIRTAILECRYVCGSVALASELETRFDHEIVRNTGPEFIAAKLAERDERHRKAGDTRYLVEPNVKEGKGGLRDLHTLFWISKYFYRVKDSADLVKLGVLSRQEYKLFQKAEDFLWAVRCHMHFLTGKAEERLSFDIQREIAEALGYHDHPGLSAVERFMKHYFLVAKDVGDLTRIFCSALEDQQAKDAPGISGVISRFRNRVRKIPGTLDFVDDGGRIALASPDVFKRDPVNLLRMFHIADINGLEFHPAALKQVTRSLSLITPHLRENEEANRLFLSILTSRRNPELILRRMNEAAVLGRFIPEFGKIVSMMQFNMYHHYTVDEHLLRAVDVLSRIERGLEEEAHPLTAMLMPAIEDREALYVAVLLHDIAKGRPEDHSVAGAKVARKLCPRFRLSPKQTETVVWLVEEHLTMSMVAQTRDLNDRKTIVDFAERVQSLERLKMLLILTVCDIRAVGPGVWNGWKGQLLRTLYYETELLLSGGFSELSRKERAKHAADMLEEALADWPKEERQTYVRLHYQPYLLTVALDEQVRHAAFIREADAAGRTLATMVRTHDFHAITEITVLSPDHPRLLTVIAGACAAAGANIVGAQIHTTSDGRALDTILVNREFSVAEDETRRAASIGKLIEDVLSGRKKLPDVIASRTRSKKRSRAFTVTPEVTISNALSNKFTVIEVEGLDRTGLLSEVTAVLSDLSLDIASAHITTFGEKVIDTFYVTDLVGSKITSENRQMNIAARLKAVLAGEVDEARERMPSGIIAPTPVPRASHGSKATKAET
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: ASNA_LACPL
Sequence: MHLIIPKDYDPKLSVKETQQAIRYIRETFQDEFGKQLNLSRLSAPMFVEKKTGLNDNLNGVEKPVSFTMQDMGDEQIEIVHSLAKWKRVALKRYGFDMHEGLYTNMNAIRKDEDLDNYHSAYVDQWDWEKVISKEERTVETLKAAVRQIFKVIKHMEHEVWYKFPQAVHHLPDEIHFLTTQELEDMYPDMTPRERENAICKKLGCVFLMQIGWKLDSGERHDGRAPDYDDWKLNGDILFWYEPLDQAIEISSMGIRVDAESMKKQLKDVDAEDRLSLPYHQMILNADVPYTIGGGIGQSRLCMLLLGKAHVGEVQAALWHKP
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISL1_HUMAN
Sequence: MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
What is the function of this protein?
DNA-binding transcriptional activator.  Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes.  Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation.  Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina.  Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity).  Binds to insulin gene enhancer sequences (By similarity).  Essential for heart development.  Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart.  Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).
What are the official names of this protein?
Insulin gene enhancer protein ISL-1, Islet-1.
What are the subcellular locations of this protein?
Nucleus.