PharMolix/UniProtQA huggingface dataset:
Protein: LEP4_BURP2
Sequence: MPTASMTPNPFLSGSPEHAAAAGPLAAFAALPTGMQLAFAIVLGLVVGSFLNVVVHRLPIMMKRAWLAEIAEATGAPCADDSLPARYNLCVPRSACPHCGHALRAWENVPVLSYIALRGRCRHCRTPIGARYPLIELASGALAAGALALFGPSGAALAAFGLCAALLAMSAIDMQTGFLPDSLTLPLLWAGLCVNLWGTFASLRAAVIGAIAGYLFLWCILWLFKLLRGIEGIGYGDLKLLAALGAWLGWEALPQVVLIAAVAGAAVGLVATWRGRMRFEEPLPFGPFLAAGGAATLFFGTPFYLLLGG
What is the function of this protein?
Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.
What are the official names of this protein?
Prepilin leader peptidase/N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A24 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS4E_PYRAE
Sequence: MVHLRRTLAPAWWPIPRKKGGVWVVRPSPGPHSLAYSLPLALIIRDVLKYAKTMHEARYIISRGYVKVDGVVRRDYKFPVGLMDVIEIVPTGEVYRVVPDADKYYNLLPISTEEAALKLLRVEGKTMVKGGRIQLHFHDGRNLITTLEAGKQIKTFDSVLYDLRNKAIKAHIPLKLGVNAVVIHGSNVGFSGTLYEIVWTLKRKQSVVALKKGDEVRRTILNYVMAVGSEGPVIKISP
What are the official names of this protein?
30S ribosomal protein S4e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: RS12_GEOSE
Sequence: MPTINQLVRKGREKKVFKSKSPALNKGYNSFKKEQTNVASPQKRGVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLRGVRYHIIRGGLDTAGVANRMQGRSKYGAKKPKAAKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12, BS12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: DGGGP_PYRHO
Sequence: MEPKAFVEIMRPHNCILAGIVGILGSLVAYEGIPPVQKLILIFLVVYFGCSAGNTINDYFDVEIDKINRPNRPIPRGAITRKAAFYYGVLQYFIGLIIALLLGWSAFLFALGAYFLTFVYAWKLKPLPFIGNVTVALLTAATPIYGAVGVGRIDLAGYLAICAFLVNVSREIMKDIEDFEGDKRLGARTLPIMIGKKKSGIIASIFGFLTIISSFLPVKVGIGLGYLPIIIVDIMIAKASIDVLVNPEKAGKGQKILKFATFIAVISFLLGALTREV
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP).  This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Digeranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYH_LEIXX
Sequence: MASPITPPRGMRDFLPAEKARREHALGVIRRSFSAHGFDEIETPVAEDVARLHAGLGGDNEKLAFSVLKRGLSGDDLRAAIESGDTLSLCDLGLRFDLTVPLARFFASHRAELSPVFRSLQIAPVWRAERPQKGRYRQFVQCDIDIVGEASQLAEAELITATAATLDALGLKDCTIRVNDRRILNALLQHCGFAEARWPRALISIDKLDKIGAEGVVAELSEGAADAAAALGGVLAGFEPHLADGGVELTAQAILRILPAGVDTAAIGELETLAHALGALPTGVRLRFDPKLVRGMGYYTGVIFEIAHPGSGSSVGGGGRYDGMIGRFLGTEVPACGFSIGFERVVDLIELPESAGPDSVVLVYDPAMPIGRLLAIKSDLAAAGRRVRLDRRAKNLKAVLDRAAAAGFRSFAFVDADTPAVALDLKPLTEL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAA_PEA
Sequence: MIIRSPEPKVQILADPEVKILVDRDPIKTSFEQWAKPGHFSRTIAKGPDTTTWIWNLHADAHDFDSHTSDLEEISRKVFSAHFGQLSIIFLWLSGMYFHGARFSNYEAWLNDPTHIGPSAQVVWPIVGQEILNGDVGGGFRGIQITSGFFQIWRASGITSELQLYCTAIGALVFAGLMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWARHQVHVSLPINQFLNAGVDPKEIPLPHEFILNRDLLAQLYPSFAEGATPFFTLNWSKYADFLTFRGGLDPLTGGLWLTDIAHHHLAIAILFLIAGHMYRTNWGIGHGIKDILEAHKGPFTGQGHKGLYEILTTSWHAQLSINLAMLGSLTIVVAQHMYSMPPYPYLATDYATQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTRYNDLLDRVLRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIQNTHALAPGTTAPGATASTSLTWGGGDLVAVGNKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNSISVVIFHFSWKMQSDVWGTINDQGVVTHITAGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLFFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPATQPRALSIVQGRAVGVTHYLLGGIATTWAFFLARIIAVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TSAC_VIBVY
Sequence: MVSNLQQVVKALKQGQVVAYPTEGVFGLGCDPDNEVAIERLLTIKQRPSDKGLILIAADFQQLQPYLDLTSLSAEQLQRVFATWPGPYTWVMPASARASALVTGYRQTVAVRVSDHPLVQKLCSEYGKPLTSTSANLSGQTECKTVEQVQDQLGSQISVILFGEIGERHRPSEIRDARTEQLLRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_MYCSK
Sequence: MSDAQVAKTDVVLVGAGIMSATLSALIKLLEPNWSITLIERLDGAAAESSDPWNNAGTGHSALCELNYTPEGPGGSIDITKAVHVNEQFQVSRQFWTYAVENGVLPDVRNFINPIPHVSFVSGARNVEYLRARYDALVPNPLFATMEYIDDRDEFARRLPFMADKRDFREPVALNWSQDGTDIDFGSLSRQLIGYTAQRGMTTLFGHEVRDLDKQSDGSWSVKVVNRRTGAKRKLNAKFVFVGAGGGALPLLQKAGIEEAKGFGGFPVGGQWLRTGNPELTARHQAKVYGMPPLGAPPMSVPHLDTRVINGKSWLLFGPFAGWSPKFLKQGKVTDLPFSVKPNNLASMLGVGLTEMGLLKYLIGQLLLSEADRVETLRNFAPSARDSDWELDIAGQRVQVIRRKGKGGVLEFGTTVLAAKDGSIAGLLGASPGASTAVPAMLDVMERCFGDRYTAWLPKLKEIVPSLGTKLSDEPKLFQEIWAHGTKVLKLDHPAAGLPVAGTDTEHREPATTVTA
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: FMQB_ASPFU
Sequence: MKLPAAAGDAIVIGPNAVRLIKSWGEQLCEEIEPHLSNATHAEMLDHHDRFIVRHELAGRGKGWFTNRGRLISILYEHARKLGIDIRLGSRVTKYWEEDGRAGVIVNDRERLAADCVICADGVHSAARAWLTGQVDTQQHSGWANFRAHMTTEQLAKDPEASWVLQGTREKDRVYVWFGDGINLAIMTMKRGQELAWALMHTDKFNAHESWAGGRASIDDALATLSPWPGRLRPSSVIRHTLPEKLVDHALIYRPPLDTWVSAGGRVMLIGDAAHPYFPVVGQGGSQAIEDGVVVATALELAGKENVPLALRIRATLTEENNVLMEAGNSRYPRATVIQLGSSTLQEHLFWPDWEAVAKDPSVFAFPNPEWILGHDCREYTHQVFDTVVRAVRGEGEYIPRNIPADGAYRVEDTYSPE
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the antitumor fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts (PubMed:20225828, PubMed:20804163, PubMed:21899262, PubMed:24612080, PubMed:33705521).  The simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from anthranilic acid (Ant), tryptophan (Trp), and alanine (Ala) (PubMed:20225828).  The trimodular NRPS fmqA is responsible for FQF formation (PubMed:20225828).  Modules 1, 2 and 3 of fmqA are predicted to activate and load Ant, Trp and Ala, respectively, providing for the assembly of an Ant-Trp-Ala-S-enzyme intermediate that would undergo double cyclization for chain release and generation of the tricyclic 6-6-6 product fumiquinazoline F (PubMed:20225828).  The presence of an E domain predicted for module 2 of fmqA is consistent with epimerization of L-Trp to D-Trp during assembly to generate the R-stereocenter at C14 of FQF (PubMed:20225828).  The FAD-dependent monooxygenase fmqB and the monomodular NRPS fmqC then maturate FQF to FQA (PubMed:20804163).  FmqB oxidizes the 2',3'-double bond of the indole side chain of FQF, and fmqC activates L-Ala as the adenylate, installs it as the pantetheinyl thioester on its carrier protein domain, and acylates the oxidized indole for subsequent intramolecular cyclization to create the 6-5-5-imidazolindolone of FQA (PubMed:20804163).  The FAD-linked oxidoreductase fmqD introduces a third layer of scaffold complexity by converting FQA to the spirohemiaminal FQC, presumably by catalyzing the formation of a transient imine within the pyrazinone ring (PubMed:21899262).  FQC subsequently converts nonenzymatically to the known cyclic aminal FQD (PubMed:21899262).
What are the official names of this protein?
FAD-dependent monooxygenase fmqB, Fumiquinazoline biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_RICBR
Sequence: MSKLKQGTFITFEGGEGIGKSTQCQMLYEYLKSQNIPVILTREVGGTNVAEKMREILVHTDLLPMSELLQAMAARYDHMVKKIIPALQAGNIVICDRFIDSTACYQGLELENGIELVYNLHKDLMPPLMPDLTFFIDVESSIAIERVNSRNMSNKFDVRGLDFYNKIYDCFKGLSKKFPERIVTIKASDLNPEQVHELIKKHLNLI
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RL14_SALEP
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVILNNNSEQPIGTRIFGPVTRELRNEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: KDPC_CERS1
Sequence: MMTHLRPALASLLALSLLTGVAYPLALTGIAAVIAPDRAAGSLILREGQVVGSALIGQGFDGPGYLHPRPSASDWNAAGTSASNLGPTSAALLAEVQERQAAYEAQNGAPAPVDAVTASGSGLDPHVSPANARAQAARIARARGLDEAAVRRLIEAHVEPPLLGLWGQARVNVLAVNLALDAAGA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: FOXN5_XENTR
Sequence: MYLRFANRKPYEKLHLSTALEDWDMSEELKLSITADQYFAGADDKVERYTLRRQHSTEVSPTRSEEGDYQECTFRPSLWLVVDPNLVIPCPEWINRIPPEPELTSPPLQLQRQLSNDYSTVEDSEDEAPTSCSDVLTDDDDSYNPWQPKHKRKKAKCLGKKLRVQKGLTQLESWPRPPLNYCNLISLALRNSEDGSLNVQQIYSFVREHFPFFRIAPDGWKNTVRHNLCFSSSFEKSSGWVCADGHRRSCLWKLTRQGRRKFRNEMHALSDDLLHVLRKSMKKPALMELMFGM
What are the official names of this protein?
Forkhead box protein N5.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_CERSK
Sequence: MAAKLKKGDRVVVLAGKDKGKQGEITAVMPKDNKAVVEGVNVAIRHTKQTPTAQGGRLAKAMPIDLSNLALLDANGKATRVGFRFEGEKKVRYAKTTGDVI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: YE152_YEAST
Sequence: MGLRLRLVLLKGRNQRLEINRVVALLVDGGHFPLESRICEAIVDQEICWRDDERLPGIPVMWQGCLQKDVQHAIRSAAIQIQIVCPCPAPSPIFELKQLIIQKRTNLLSHPQGTFVRTVRQRMPVIGVVIVLPGLGPQYSRSRLNYCFSRQQPRARMALEEIDFLVFHYRLLARVVPCYSDAPPRFMC
What are the official names of this protein?
Putative uncharacterized protein YER152W-A.
Protein: PANC_SORC5
Sequence: MEFWRHPGDLRVACDRARAGGSRVGLVPTMGALHAGHLALIAEARRRTDFVAVTIFVNPTQFGAGEDLARYPRTLERDLAACAEAGADGVFAPDVAAMYPPGEETRVRVGATAGPLCGVHRPAHFEGVATVVTKLLSLAGPCVAVFGRKDYQQLQVIRRLVADLFLPVEIVGATTVREPDGLAMSSRNAYLSPEQRRAARAIPLALAGACRAFARGERRAAALLEPARARLAAAATSIDYVDLADPESLAIWSDSAAIGERALLAVAVRVGTTRLIDNVVLGEDAPPVAEPSEEAS
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REPA_MSVTA
Sequence: MASSSSNRQFSHRNVNTFLTYPHCPENPEIVCQMIWELVGRWTPKYIICAQEAHKDGDMHLHALLQTEKPVRITDSRFFDIEGFHPNIQSAKSVNKVRDYILKEPLAVFERGTFIPRKSSFQGNPSKGNSEKKPSKDEIMREIISHSTSKLEYLSMIRKEFPYDWATKLQYFEYSANKLFPEIQEEFISPHPPSSPDLLCNESIKDWLQPNIFQVSPESYMLLQPTCYTLEDAISDLEWMDKLSSQQMKEQESRASTSSVQQELGNLLGPEA
What is the function of this protein?
Implicated in enhancement of V-sense gene expression.  Acts a an inhibitor of C-sense gene transcription (By similarity).
What are the official names of this protein?
Replication-associated protein A, RepA.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: RPOB_BACFN
Sequence: MSSNTVNQRVNFASTKNPLEYPDFLEVQLKSFQDFLQLDTPPEKRKKEGLYKVFAENFPIADTRNNFVLEFLDYYIDPPRYTIDDCIERGLTYSVPLKAKLKLYCTDPDHEDFDTVIQDVFLGPIPYMTDKATFVINGAERVVVSQLHRSPGVFFGQSVHANGTKLYSARIIPFKGSWIEFATDINNVMYAYIDRKKKLPVTTLLRAIGFENDKDILEIFNLAEDVKVNKTNLKKVVGRKLAARVLKTWIEDFVDEDTGEVVSIERNEVIIDRETVIEPEHIDEIIDSGVQNILIHKEEPNQSDYSIIYNTLQKDPSNSEKEAVLYIYRQLRNADPADDASAREVINNLFFSEKRYDLGDVGRYRINKKLNLTTDMDVRVLTKEDIIEIIKYLIELINSKADVDDIDHLSNRRVRTVGEQLSNQFAVGLARMSRTIRERMNVRDNEVFTPIDLINAKTISSVINSFFGTNALSQFMDQTNPLAEITHKRRMSALGPGGLSRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLCVFAKINDLGFIETPYRKVDNGKVDLSENGLVYLTAEEEEAKIIAQGNAPLNDDGTFIRNKVKSRQDADYPVVEPSEVELMDVAPQQIASIAASLIPFLEHDDANRALMGSNMMRQAVPLLRSEAPIVGTGIERQLVRDSRTQIAAEGDGVIDFVDATTIRILYDRTEDEEFVSFEPALKEYRIPKFRKTNQNMTIDLRPTCNKGDRVTKGQILTEGYSTENGELALGKNLLVAYMPWKGYNYEDAIVLNERVVREDLLTSVHVEEYSLEVRETKRGMEELTSDIPNVSEEATKDLDENGIVRVGARIQPGDILIGKITPKGESDPSPEEKLLRAIFGDKAGDVKDASLKASPSLKGVIIDKKLFSRVIKNRSSKLADKALLPKIDDEFESKVADLKRILVKKLMVLTEGKVSQGVKDYLGAEVIAKGSKFSASDFDSLDFTAIQLSDWTNDDHANGMIRDLILNFIKKYKELDAELKRKKFAITIGDELPAGIIQMAKVYIAKKRKIGVGDKMAGRHGNKGIVSRVVRQEDMPFLEDGTPVDIVLNPLGVPSRMNIGQIFEAVLGRAGKNLGVKFATPIFDGATLDDLNEWTDKAGLPRYCKTYLCDGGTGERFDQPATVGVTYMLKLGHMVEDKMHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEGFGASHILQEILTIKSDDVVGRSKAYEAIVKGEPMPQPGIPESLNVLLHELRGLGLSINLE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CYSD_SHELP
Sequence: MSTQQTHLKQLEAESIQIMREVAAEFENPVMLYSVGKDSSVLLHLARKAFYPGKIPFPLLHVDTNWKFKEMIEFRDRMAKQYGFDLIVHKNPRGLEMNISPFTHGSAKHTDIMKTEGLKQALDMHGFDAAFGGARRDEEKSRAKERVYSFRDSKHRWDPKNQRPELWNIYNGKVDKGESIRVFPLSNWTELDIWQYIYLENIEIPSLYLAEPRPVVKRDGTLIMVDDERMELEPGEAVEQKMVRFRTLGCYPLTGAVESQATTLPEIIQEMLLCTTSERQGRVIDNDSAGSMEKKKMEGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: HEM1_CAMC1
Sequence: MHYLDISFTYKNTDISVREKLAFDSDEKKEQILKLINSNKNIKESMVLNTCNRVEIIASVEDVKAATAHIIRCMSIFSGVFEDELYERADIYENSGAAHHLFAVASSLDSLVVGETQIVGQLKNAFKFAYDNNSCGEDISKIIHYACKCAAKVRNETQISKNPISVSSVAVAKAKEIFGTLEGKTAIVVGAGEMGELAAKHLISSGAEVIIINRSSERVEQLVDSLGDNASWDSILKLKEYVNNYDLIFSSTAAPHAIITGEIIEPREFHRYFFDIAVPRDIDLLNTELISVYTVDSLEEIVRKNLALREEQAQKAYSIVGQDTSEFLKTLKEDMSVPLIKSIRKQAEICAKNELEKAIKKGYLKHSDYDEAQKLIHQVFKAFLHQPTMKLKGLADEERASELSNGVKFLFDIKDEQNFQAGDIDEI
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: AERC_AERSO
Sequence: MMIKRHLPQPRHRERPGALCGSGVPAPAARHPTAVPGGQDQFGSATHHGSDGQTHTGPQIR
What is the function of this protein?
Regulation of the expression of aerolysin.
What are the official names of this protein?
Aerolysin regulatory protein.
Protein: ZN445_HUMAN
Sequence: MPPGRWHAAYPAQAQSSRERGRLQTVKKEEEDESYTPVQAARPQTLNRPGQELFRQLFRQLRYHESSGPLETLSRLRELCRWWLRPDVLSKAQILELLVLEQFLSILPGELRVWVQLHNPESGEEAVALLEELQRDLDGTSWRDPGPAQSPDVHWMGTGALRSAQIWSLASPLRSSSALGDHLEPPYEIEARDFLAGQSDTPAAQMPALFPREGCPGDQVTPTRSLTAQLQETMTFKDVEVTFSQDEWGWLDSAQRNLYRDVMLENYRNMASLVGPFTKPALISWLEAREPWGLNMQAAQPKGNPVAAPTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSRQKDQCENPIQVRVKKEETNFSHRTGKDSEVSGSNSLDLKHVTYLRVSGRKESLKHGCGKHFRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQSLHTVGVSFKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHTGVKPYKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCSQCRKSFHCKSYVLEHQRIHTQEKPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECREGFRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKPEGGPSFSQDTVFQVPQSSHSKEEPYKCSQCGKAFRNHSFLLIHQRVHTGEKPYKCRECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEKRFWCQECGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSHQRKHTRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQDISIGKKCHKCSICGKTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSNLARHMKNHIRD
What is the function of this protein?
Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation.  Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440).  Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance.  In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440).
What are the official names of this protein?
Zinc finger protein 445, ZFP445, Zinc finger protein 168, Zinc finger protein with KRAB and SCAN domains 15.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Note=Binds various differentially methylated regions (DMR).
Protein: TOR4A_XENTR
Sequence: MEDSESSTQAPAAHHGISLASSPVRALIRMRRKIRTLKKSRLQLDLTTGRPLDSAKASLRRQISTDRASLFKTTTYEKQQYFNFDTPTLEKLALNNQIRKKNRKKSRHVLYPGNVRKCLPVEQKSKAKRCLLLFIAIVCFQIFNAIENLDDNLQKYDLDGLEKTLQREVFGQRRAIDKLMDHLKDYLATHYHNKPLVLSFNGPSGVGKSHTGRLLAKHFRSVMDNDFVLQYYTMHNCPDENDVAKCQAEVSGMISEMISRAEIEEKIPVFIFDELEVMPVALLDVLHGYFQLNQSNEYLNAVYILISNIGGNEITKFVLQNSSKDFVNVPQELRHLVLTSLRKQHFLWDVAEIVPFTLLEKRHILDCFLDELLREGLYPDHSNIESLAGQLRYYTKENKEYSITGCKQVVAKVNLLQPYT
What are the official names of this protein?
Torsin-4A, Torsin family 4 member A.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. Torsin subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MRGX4_HUMAN
Sequence: MDPTVPVFGTKLTPINGREETPCYNQTLSFTVLTCIISLVGLTGNAVVLWLLGYRMRRNAVSIYILNLAAADFLFLSFQIIRLPLRLINISHLIRKILVSVMTFPYFTGLSMLSAISTERCLSVLWPIWYRCRRPTHLSAVVCVLLWGLSLLFSMLEWRFCDFLFSGADSSWCETSDFIPVAWLIFLCVVLCVSSLVLLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGILGALIYRMHLNLEVLYCHVYLVCMSLSSLNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDKPEVDKGEGQLPEESLELSGSRLGP
What is the function of this protein?
Orphan receptor.  Probably involved in the function of nociceptive neurons.  May regulate nociceptor function and/or development, including the sensation or modulation of pain.  Potently activated by enkephalins (By similarity).
What are the official names of this protein?
Mas-related G-protein coupled receptor member X4, Sensory neuron-specific G-protein coupled receptor 5/6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NRFA_HAEI8
Sequence: MKIYLRFVWILIIILNFLLNLFITTNGVIIVNAFKKSLIVAASFASLSLFNSATAELVYKPLEQPVEPAKPDLKIESVNEKFAEKYPNQYNSWRSTANGDGENIIYADEENPRLIVLWGGYAFAKEYNAPRGHFYAVTDVRNILRTGAPKTANDGPQAMACWTCKGPDVPRLIAEWGEKDYFNAKWAKGGPEIVNSIGCADCHDTTSKDFAEGKPALRIARPHVLRALDALEKATAEKDKAEGRPHNNLSFNTAARTEKRAEICANCHVEYYFAGDIKQVTFPWDNGQTADDIEKYYDDIGFTDWTHSLSKAPMLKAQHPDFEIWSLGMHGKNGVTCVDCHMPKVQGADGKVYTDHQIQNPFDAFDHTCANCHDQSKEKLRDIVTSRKKEVKDVMGRLEDQVVKSHFEAKAAWDAGATKEEMEAALMDIRHAQWRWDYTAASHGGHMHAPEVVLRVLASGLDKVADARTKLAVILTKHGVKTPVQIPDISTADKAWKVMGIDIEKERKAKEEFLKTVVPQWEQQAREKGLLVDPPAQK
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: IF3_STRP7
Sequence: MFFSNKTKEVKTIAKQDLFINDEIRVREVRLIGLEGEQLGIKPLSEAQALADNANVDLVLIQPQAKPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPTIDKGDFDTKLRNARKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKMDGRQMFMQLAPATDKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.