PharMolix/UniProtQA huggingface dataset:
Protein: PXPA_ECOSM
Sequence: MKIDLNADLGEGYASDAELLTLVSSANIACGFHAGDAQTMQACVREAIKNGVAIGAHPSFPDRENFGRSAMQLPPETAFAQTLYQIGALAAIARAQGGVMRHVKPHGMLYNQAAKEAQLADAIARAVYACDPALILVGLAGSELIRAGKQYGLTTREEVFADRGYQADGSLVPRSQPGALIEDEEQALAQTLEMVQHGRVKSITGEWATVTAQTVCLHGDGEHALAFARRLRATFAEKGIVVAA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: TGT_DESRM
Sequence: MPVKIKIEKKEKHTRARLGKLTTPHGEVETPIFMPVGTQATVKTMTPEEVKETGGRLVLSNTYHLYLRPGHDLVKEAGGLHKFMNWDGPILTDSGGFQVFSLGPLRTITEEGVEFRSHIDGSKHFFTPEKVMEIEQALGADIAMAFDECAPYPCEKEYAVAALERTTRWAERCKRVHKREDQALFGIIQGGVFPDLRERSAKELLAMDFPGYGIGGLSVGEPKELMYEVLDQLMPIMPEDKPRYLMGVGSPDCLIEGVVRGVDMFDCVLPTRIARNGTVFTHNGKLTVRNAEYARDFRPMDQQCDCYACRNYSRAYIRHLIKTDEILGIRLTTIHNLHFIQHLMQNIRQAIREDRLLEYREDFLKVFNAG
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NADK_VIBC1
Sequence: MKNPCNVIAIIGKPRDQQAIQTHRELYEWLTSEGYQVFIDDRLAAILDEIPQSQFASLVELGKNADLAIVVGGDGNMLGAARILSRFDVAVIGVNRGNLGFLTDLNPDDFKEALKAVLKGKYIEEERFLLEAEIHRHGQIKSHNAALNEAVLHPGQVAHMIEFEVYIDDSFAFSLRADGLIVSTPTGSTAYSLSGGGPILSPSLNAISLVPMFPHTLSSRPLVVDGKRRIKLIVSPENRGTQEVSCDGQVSLPVSPGDEIHIYQSPNVLKLIHPKDYSYYHVLRNKLGWSSKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_PASMU
Sequence: MQYQHDSLDKLKLGQQTQYASNYDHTLLQPVPRHLNRDTLGITHTQPFHFGADIWTAYEISWLNLNGLPQVAIADVAIDFQSENLIESKSFKLYLNSFNQSKFATFEEVQQHLTQDLSNCAKGKVSVKLHPLSKYCHEPIVELAGECIDQQDIEINDYQFNPEILTNCTHDQMVKESLVSHLLKSNCLITNQPDWGTLQIRYEGKQIDREKLLRYIISFRQHNEFHEQCVERIFCDLMQFAKPDKLTVYARYTRRGGLDINPFRSNFEAVPDNQRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_HELHP
Sequence: MSKEEVLLNEEIDFKEVRCVSDNGEVYGIISSKEALNLAHKAGLDLVLISPNAKPPVCKIMDYGKFRYQAEKKQKEARKKQKQIEIKEIKLSTQIAQNDINYKVKHAIEFLESGKHVKFKVFLKQRELNIPDAGMDTLGKVAVMLEDIAIAEKEPKLEGKHLNVLYVPKKKEKH
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKGG_ECOLI
Sequence: MDNRGEFLNNVAQALGRPLRLEPQAEDAPLNNYANERLTQLNQQQRCDAFIQFASDVMLTRCELTSEAKAAEAAIRLCKELGDQSVVISGDTRLEELGISERLQQECNAVVWDPAKGAENISQAEQAKVGVVYAEYGLTESGGVVLFSAAERGRSLSLLPEYSLFILRKSTILPRVAQLAEKLHQKAQAGERMPSCINIISGPSSTADIELIKVVGVHGPVKAVYLIIEDC
What are the official names of this protein?
Uncharacterized protein YkgG.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: GATD_PYRFU
Sequence: MRVEEFLKQKGIEVGDYVRIIKVEDGEKVEYEGIVMPPYELSEGDTVVIKLDNGYNIGIAIEKIQEINVIEKAKAKPEVHFKAELEPRKELPTITILGTGGTIASRIDYETGAVYPAFTAEELAKAVPEIFEIANIKPKLLFNIFSEDMKPKHWIEIAHETAKALNSGNEGVVIAHGTDTMGYTAAALSFMLRNLTKPVVLVGAQRSSDRPSSDAAMNLICATRMAVSDAAEVMVVMHGETSDTYCLAHRGTKVRKMHTSRRDAFRSINDIPIAKIWSDGKIEFLRDDYRKRSEGEVWVDDKLEEKVALVKVYPGMSAELIDFLVDKGYKGIVIEGTGLGHTPSDLIPSIKRAVDEGVAVCMTSQCLYGRVNLNVYATGRKLLKAGVIPCEDMLPETAYVKLMWVLGHTNDLREAKKMMLTNYAGEITPYTKPNTFLI
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit D, Glu-ADT subunit D.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family. GatD subfamily.
Protein: RNH2_CHRVO
Sequence: MPLKLRVAGVDEAGRGPLAGAVFAAAVILDPAKPIAGLADSKVLSEAQRDELAVLIKRDALAWCVASASVEEIDKLNILHATMLAMTRAVEGLPVRPDLAQIDGNRVPKHLPVPGEAIVKGDAKVAAISAASILAKTARDAELVALDALHPQYGFARHKGYPTAEHLAAIEAHGVLPAHRKTFGPVKAWLASHQGALF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCDB8_MOUSE
Sequence: METALTKTPEKRQVIFLAILLLLWEASSEAISYSMPEETESGYLVANLAQDLGLRVGELTTRGARIHHNGNKELLQLDAERGNLLLKEKPDREALCGATEPCVLHFQIILENPVQFFQTDLQFTDINDHFPEFPDTEMLLKIQEIAQPGTVFPLKAAQDPDIGSNAVQNYTVSPNLHFHVVTLSRSDDRKYPELVLDRALDREEQPELTLILTALDGGAPPKSGTTTVRIEVVDINDNAPQFLQSLYAVEVPENSPLNALVVTVSARDLDAGIHGNVAYSLFQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGGLSGKCTVAIQVLDVNDNAPKLTISSLTSSIPENAPEAVVAVFSVSDPDSGDNGRMVCSIQNGLPFLLKPTFKNFYTLVTERPLDRESNAEYNITITVSDLGTPRLTTQHTITVQVSDINDNAPAFTQTSYTLFVHENNSPALHIGTISATDSDSGSNGLIIYSLLPPHDQQLGLASLISINSDNGQLFALRALDYEALQAFEFHVGATDRGSPALSSEALVRVVVLDDNDNAPFVLYPLQNASAPCTELLPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDAPKHRLLLLVKDNGEPLRSASVMLQVLVVDGFSQPYLPLPEVALNPTQEEDMLTLYLVIALASVSSLFLLSVLLFVGVKLCKKAREASLADCSIPEGHFPSHLVDVSGAGTLSQSYHYEVCLTEDSGTSDFKFMNPIIPSSLLQDS
What is the function of this protein?
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable).  Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523).
What are the official names of this protein?
Protocadherin beta-8, PCDH-beta-8.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TSN4_PONAB
Sequence: MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIITGAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQRDLKKGLHLYGTQGNVGLTNAWTIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA
What are the official names of this protein?
Tetraspanin-4, Tspan-4.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MEA1_HUMAN
Sequence: MGPERHLSGAPARMATVVLGGDTMGPERIFPNQTEELGHQGPSEGTGDWSSEEPEEEQEETGSGPAGYSYQPLNQDPEQEEVELAPVGDGDVVADIQDRIQALGLHLPDPPLESEDEDEEGATALNNHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAREISDAQWEDVVQKALQARQASPAWK
What is the function of this protein?
May play an important role in spermatogenesis and/or testis development.
What are the official names of this protein?
Male-enhanced antigen 1, MEA-1.
Protein: QUEC_SOLM1
Sequence: MTTDAPQKAVVLFSGGLDSTTCLAVARRDGFLPCALSFEYGQRHKVELEAARRVAKAMAVTTHLILPLPLGSIGGSALTADIDVPKDRDIGEMEADIPVTYVPARNTIFLSMALGWAEVLGASDIYIGVNALDYSGYPDCRPEFIAAFEAMANLAVKEAVEGRLAIRIHTPLLHLSKAGIVELGTSLGVDYGLTHSCYDPAPDGLACGRCDSCLLRRKGFEEAGVADPTRYRPSL
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: ARGB_BACLD
Sequence: MGKTIVFKCGGSVIRELSDEFFQNLKDLTESGWKIALVHGGGPDITKMLKKLNIRTEFVNGQRKTTKAVLEVAEMVLSGSINKFFVAELTKHGLPAVGVSGKDGGLLLADYLNEKEYGQVGRIKKVNGQMAEALMEKGFIPVIAPLSMTDGCETLNVNADLAASAVAAALRADKLMFVTDVKGIMKNEEMLKELTPEDIESLIAEGVISGGMIPKVHSAKEALTDEVEEVMIVSGKGSFLTKDDFIGTKIIKQKEAVS
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIP_LEGLO
Sequence: MKMKLVTAAIMGLAMSTAMAATDATSLTTDKDKLSYSIGADLGKNFKNQGIDINPDVLAKGMQDGMSGAQLILTEEQMKDVLSKFQKDLMAKRSAEFNKKAEENKAKGDAFLSANKSKPGIVVLPSGLQYKIIDAGTGAKPGKSDTVTVEYTGTLIDGTVFDSTEKAGKPATFQVSQVIPGWTEALQLMPAGSTWEVFVPADLAYGPRSVGGPIGPNETLIFKIHLISVKKAA
What is the function of this protein?
Essential virulence factor associated with macrophage infectivity.  Exhibits PPIase activity.
What are the official names of this protein?
Outer membrane protein MIP, Macrophage infectivity potentiator, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: CSX1_SCHPO
Sequence: MSIDCLYRRSSLFDTSFVPLHSSIPATSKMSASNSDVNAPISPVVDEGKSELVSPTLERLVAPFNCSPSSTPLQDVAGVGSKMSDTLWMGDLEPWMDATFIQQLWASLNEPVNVKVMRSKASSSETLISYCFVQFSSSAAAERALMKYNNTMIPGAHCTFKLNWATGGGIQHNNFVSRDPEFSIFVGDLLPTTEDSDLFMTFRSIYPSCTSAKIIVDPVTGLSRKYGFVRFSSEKEQQHALMHMQGYLCQGRPLRISVASPKSRASIAADSALGIVPTSTSNRQPNQDLCSMDPLNTTVFVGGLASNLSEKDLQVCFQPFGRILNIKIPFGKGCGFVQYSEKSAAEKAINTMQGALVGTSHIRLAWGHNTLPVSALSQSQSQVSDEGFDRTLSANQIFGMNQSVIGANSGSSNSSGSSLKSAPVSPRTAAAQSLLPNSVVSSINGMNSVNFSTISPPPLSRSASISPTLSGSGSGLTPLSSHFPSAATGLVGGQVYPQSSVLQSSKINGSAKVQPSVKLPEWLQPFSGNNHNSFATQDLLTRVSSLKLVDDEQPASLNGSAFQARASRPWNLGRERQSSLIDLRHELEQNENGLEKSGFGLNLRGRLPPRSYSTFNCTGQYLQPSLRLSRDS
What is the function of this protein?
Regulates global gene expression after oxidative stress.  Interacts and stabilizes atf1 and pcr1 mRNAs after oxidative stress, thus controlling their turnover.
What are the official names of this protein?
RNA-binding post-transcriptional regulator csx1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YSI1_CAEEL
Sequence: MSSRYTSSYTPSSRYGSGWDYSSSYSSSRTSRDRDTGSYRDRDYSSTSYTSTRPRYSTYASKYSTDLGKSTDKGMDDYSAAPIAKDEIEELSYDAKTPTTPTEETVDAPREVLQESQISDFVEEDDDQQTEVEEVKLTLASEPEESEEEEDDEDVRKAQELLAASTQIRESSPVSSPVKEVSSAASLFANDNGNETENRTPSPTVLNAKKLGGIPWPPKSSDVKKEGGDAEALPKKRVSDLIARFNTGVVEESKKTDDAYKNEYGAGTNVGKVSTHNFA
What are the official names of this protein?
Uncharacterized protein F15G9.1.
Protein: HSCB_PROMH
Sequence: MDYFTLLGMPNRFDIDKQQLASRYQEMQRQYHPDRFAGKSDKEQVQAISFASTINQAYQTLKNPLSRAEYMLSLQGIDIANEQQTMHDTAFLMEQLTLREELDDIEHSTDAENLLADFSARLEKMYTVRYDEMVKTLDSQTWDIAADNVRKLRFLAKLKEQVEHLEERLFDGF
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: MDTK_YERPP
Sequence: MQKYIVEARSLLALAIPVVIAQLSQTAMGVVDTIMAGSVSATDMAAVAVGTSIWLPAILFGHGLLLALTPTVAQLNGSGRRSQIAHQVRQGFWLALCVSVLIMLVLYNSDHVIKQMDNIDPVLAQKAVGFLHAIMWGVPGYLFFQVLRNQCEGLSKTKPGMVIGFVGLLVNIPINYIFIYGKFGAPALGGVGCGVATASVYWVMFLMMRWYVTRARSQQDIKLEKGFAAPDWQVMKRLSGLGLPVALALFFEVTLFAVVALLVSPLGIVAVAGHQIALNFSSLMFMLPMSLSVAATIRVGFRLGQGAVEQAQVAAYTSMAVGLLLASVTAVFTIVFREHIALLYNKTPEVVTMASHLMLLAALYQLSDAVQVIGSGVLRGYKDTRSIFFITFTAYWLLGLPSGYLLGLTDYILPAMGPAGFWIGFIIGLTAAAILMVLRIRWLQKQPTAFILQRAAH
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CARB_STRP1
Sequence: MPKRKDIQKIMVIGSGPIIIGQAAEFDYAGTQACLALKEEGYKVILVNSNPATIMTDKEIADKVYIEPLTLEFVNRIIRKERPDAILPTLGGQTGLNMAMALSKAGILDDLEIELLGTKLSAIDQAEDRDLFKQLMQELDQPIPESTIVKTVDEAVTFARDIGYPVIVRPAFTLGGTGGGICSSEEELCEITENGLKLSPVTQCLIERSIAGFKEIEYEVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPTQTLSDIENQMLRDASLKIIRALKIEGGCNVQLALDPYSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMINPITGTTYAMFEPALDYVVAKIPRFPFDKFEHGERQLGTQMKATGEVMAIGRNLEESLLKACRSLEIGVCHNEMTSLSNISDEELVTKVIKAQDDRLFYLSEAIRRGYSIEELESLTKIDLFFLDKLLHIVEIEQELQMHVDHLESLKKAKRYGFSDQKIAEIWQKDESDIRAMRHSHSLYPVYKMVDTCAAEFDAKTPYFYSTYELENESVQSNKESILVLGSGPIRIGQGVEFDYATVHSVKAIQKAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDLEQPKGVIVQFGGQTAINLAQALSEAGVTILGTQVEDLDRAEDRDLFEKALKELGIPQPQGQTATNEEEALEAAKKIGFPVLVRPSYVLGGRAMEIVENKEDLREYIRTAVKASPEHPILVDSYIFGKECEVDAISDGKSVLIPGIMEHIERAGVHSGDSMAVYPPQQLSKQIQETIAEYTKRLAIGLNCIGMMNVQFVIKNEQVYVIEVNPRASRTVPFLSKVTGIPMAQIATKLILGQTLKDLGYEDGLYPQSPLVHIKAPVFSFTKLAQVDSLLGPEMKSTGEVMGSDTSLEKALYKAFEANNSHLSEFGQIVFTIADDSKAEALSLARRFKAIGYQIMATQGTAAYFAEQGLSACLVGKIGDAANDIPTLVRHGHVQAIVNTVGIKRTADKDGQMIRSSAIEQGVPLFTALDTAKAMLTVLESRCFNIEAI
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: CENPM_XENLA
Sequence: MATVRPFDKMPMLNAAALLLVGTEESHREQLASAMLKEPKTFEVKIHMAQSLPLPYEREHLRPRFDMVVFLINLHSQLSLSTILASLTQLDVNFFLGKVCFVATGGGQVKHCMVDIATVKKLADTHLSTLLFSEFASEDDVTCTAQRLLQMLKICAGLVPGISALYLGSFMSSTLQTDQF
What is the function of this protein?
Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
What are the official names of this protein?
Centromere protein M, CENP-M.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres.
Protein: RL34A_YEAST
Sequence: MAQRVTFRRRNPYNTRSNKIKVVKTPGGILRAQHVKKLATRPKCGDCGSALQGISTLRPRQYATVSKTHKTVSRAYGGSRCANCVKERIIRAFLIEEQKIVKKVVKEQTEAAKKSEKKAKK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L34-A, Large ribosomal subunit protein eL34-A.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL34 family.
Protein: DDI1_MACFA
Sequence: MLITVYCVRRDLSEATFSLQVSPDFELRNFKVLCEAESRVPAEEIQIIHMERLLIEDHCSLGSYGLKDGDVVVLLQKDNVGPRAPGRAPNQPRIDFSGIAVPGTSSSRPQHPGQQQQRTPAAQRSHGLASGETVGVPQGLGSPGLIRSMLLSNPHDLSLLKERNPPLAEALLSGSLETFSQVLMAQQREKALREQERLHLYTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQVTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPLCSRMVNGKDESSDKEITHSVMDSGRKEH
What is the function of this protein?
Probable aspartic protease (By similarity).  Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2.  Required, with DDI2, for cellular survival following replication stress.  Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity).
What are the official names of this protein?
Protein DDI1 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the DDI1 family.
Protein: RUVC_RUBXD
Sequence: MLGSQTKQVILGIDPGTATMGWGVVRQEGSRLRYVQHGAITTPSGWGMPRRLDRLFAGVTELIRGYRPSAVAVEELFFNTNVTTAITVGQARGVALLAAYRAGVEVFEYTPLQVKQAITSYGRADKRQVQEMVRALLGLRSIPRPDDAADGLAIAICHAFSHRMSAATGVGKPRAMQDN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: DLD_HAEIN
Sequence: MSVQQLISRLTDIVGSRYIITDPTKTEAYRSGYRFGTGNALAVVRPATLLEFWNIVKVCVEHDVIVINQAANTGLTGGSTPDGNDYDRDIVVINTMRIDGIQLINNASQVICLPGSTLNELENQLKPFGREPHSVIGSSCIGASVIGGICNNSGGALVQRGPAYTEMALYAQLNEKGELELKNHLGIDLGETPEEILTNLQEKRYQVKDIRQDCGHGHDHYYCNYVRQVDEGSPARFNADPARHYEASGCAGKLAVFAVRLDTFPLEKETAVFYIGTNQTSVLSDIRRHMLVNFEVLPISGEYIHRDAFDIAAKYGKDTFWVIKKFGTHWLPKLFSLKSNVDRIGKKFFFLPQHLSDKFMQTVSKFIPEHLPQSLWDYRNKYEHHLIIKMGGKGIQEAREYLESYIADGSKGGYFECNAIETQAAMLHRFAVASAAIRYRAIHEKEVEEIVALDVALRRNDQDWFEVLPPEIDNRIISKLYYGHFMCHVFHQDYIVKKGYDYEELEYEMLKLLDKRGAQYPAEHNVGHLYEAKPTLRKFYKELDPTNSFNPGIGKTTRKKYWAE
What is the function of this protein?
Catalyzes the oxidation of D-lactate to pyruvate.
What are the official names of this protein?
Quinone-dependent D-lactate dehydrogenase, D-lactate dehydrogenase, D-LDH.
What is the protein family that this protein belongs to?
Belongs to the quinone-dependent D-lactate dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CBPA_SALDC
Sequence: MELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQLWQHRNDPQFNRQFQQHEGQPYNAEDFDDIFSSIFGQHGRHSHHRHAARGHDIEIEVAVFLEETLEEHQRTISYSVPVYNAFGLVEREIPKTLNVKIPAGVSNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVNQDLEVVLPLAPWEAALGAKVSVPTLKERILLTIPPGSQAGQRLRIKGKGLASKKHTGDLYAIIKIVMPPKPDEKTAALWQQLADAQSSFDPRQQWGKA
What is the function of this protein?
DNA-binding protein that preferentially recognizes a curved DNA sequence.  It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock.  Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK.  Its activity is inhibited by the binding of CbpM.
What are the official names of this protein?
Curved DNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: IF1_STAAW
Sequence: MAKQDVIELEGTVLDTLPNAMFKVELENGHEILAHVSGKIRMNYIRILPGDKVTVEMSPYDLTRGRITYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHH_CHAVU
Sequence: MLIRKTNSMIVSMGPHHPSMHGVLRLIITLDGENVIDCEPVLGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITINAPEKLANIQVPKRASYIRVIMLELSRIASHLLWLGPFMADIGAQTPFFYILREREMIYDLFESATGMRMMHNYFRIGGVAVDLPYGWIDKCLDFCEYFLPKVNEYENLITQNPIFLKRVEGIGVINKEEAINWGLSGPMLRASGMEWDLRKVDHYECYDELDWSVQWEKRGDCLARYIVRVGEMRESVKIIQQALKAIPGGPYENLEARKLNTKKSTQWNDFEYQFISKKSSPTFKIPKQEHYVRLEASKGELGIFLIGDDNIFPWRWKIRPPGFINLQVLPPLVNGMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: MED11_MOUSE
Sequence: MATYSLANERLRALEDIEREIGAILQNAGTAILELSKEKTNERLLDRQAAAFTTSVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKISDVARTCEQMLEN
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 11, Mediator complex subunit 11.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 11 family.
What are the subcellular locations of this protein?
Nucleus.