PharMolix/UniProtQA huggingface dataset:
Protein: RLMD_HAEP3
Sequence: MALLYAPQKKQKTTQKIVAEIQDLDYQGLGVAKIQGKTWFIENALPTEKVEAVVTDEKRQYGLATAQKWLQESSQRVEPQCRYYGRCGGCQGQHIPVEMQRKAKEKALFSRLSKLQAEPIQLMPMICGEQWAYRRRVRLSLLWNAKSKTVEMGFRQKNSNQLVSIQQCLVAEQAINDLIPKLTSLLAQYSAPKQLGHIELVSAENGVAMLLRYKGNLAETDRTLLLEFARVNAVNLFLQDDQNIQLVHGEMPYYALDDIRLSFDIRDFIQVNTRLNQQMVETALDWLDLNQDDHVLDLFCGMGNFTLPLAKRVKSAVGIEGVLDMVKKAQANAQFNHIENVEFYQADLDQSFSEQPWSKQHFNKILLDPPRSGAAFALNALCELGAESILYVSCNPATLVRDAEILRSFGYRIIKTAMIDMFPNTSHLESVTLFIK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: Y5513_BACC1
Sequence: MGNEFRVCDDCQATNVKTLIPKLKKVDSCATIEVGCQSYCGPGRKKSFAFVNNRPVAAPTEDELIVKIEAKLNK
What are the official names of this protein?
UPF0741 protein BCE_5513.
What is the protein family that this protein belongs to?
Belongs to the UPF0741 family.
Protein: AL9A1_HUMAN
Sequence: MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF
What is the function of this protein?
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro).  Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.
What are the official names of this protein?
4-trimethylaminobutyraldehyde dehydrogenase, TMABA-DH, TMABALDH, Aldehyde dehydrogenase E3 isozyme, Aldehyde dehydrogenase family 9 member A1, Gamma-aminobutyraldehyde dehydrogenase, R-aminobutyraldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TRUA_ECOHS
Sequence: MSDQQQPPVYKIALGIEYDGSKYYGWQRQNEVRSVQEKLEKALSQVANEPITVFCAGRTDAGVHGTGQVVHFETTALRKDAAWTLGVNANLPGDIAVRWVKAVPDDFHARFSATARRYRYIIYNHRLRPAVLSKGVTHFYEPLDAERMHRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRHGPYVVVDIKANAFVHHMVRNIVGSLMEVGAHNQPESWIAELLAAKDRTLAAATAKAEGLYLVAVDYPDRYDLPKPPMGPLFLAD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: Y858_HELPJ
Sequence: MPFINIKLVPENGGPTNEQKQQLIEGVSDLMVKVLNKNKASIVVIIDEVDSNNYGLGGESIHHLRQKN
What are the official names of this protein?
Probable tautomerase jhp_0858.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.
Protein: THIM_BACCN
Sequence: MHITEIAKVVEQVRKTNPLVHNITNVVVTNFTANGLLALGASPVMAYAKEEVAEMASIAGALVLNMGTLRPDEVEAMLIAGKAANQQHVPVLFDPVGAGATLYRTEVARHIPNEIKLAMIRGNAAEIANVIHEKWEIKGVDAGTGNGDSVAIATKAANKLGTVAVITGKEDIVTDGKRTVIIRNGHPILTKVTGTGCLLTSVMGAFVAVEQDYVKAAVAALTFYGVAAEIAASKTVDQGPGSFQVEFLNQLANVTVSDIEQYGKAEEVR
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RK14_CUSGR
Sequence: MIQSQTQLNVADNSGARKIMCIRIIGSSNRRYAHIGDIIVAVIKDAVPNMTLEKSEVVRAVIVRTRKELKRDNGIILRYDDNAAVIIDKEGNPKGTRIFGAIPRELRKLNFNKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, plastid.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid.
Protein: TTCA_AGRFC
Sequence: MNILTKIDDFVDQAGADKVGADHGPSEENGSSHPLFDNAPRSVSFNKLRKRLLRNVRQAFEDFGMLNGQKRWLVGLSGGKDSYGLLALLLDLKWRGLLPVELVACNLDQGQPNFPKHVLPEYLAKIGVAHRIEYRDTYSIVKEKVPSGGTYCSLCSRLRRGNLYRIAREEGCDALLLGHHREDILETFFMNFFHGGRLAGMPAKLLNDEGDLMVMRPLAYCAEEDMAKFAAAMEFPIIPCDLCGSQDGLQRNAMKDMLADIERRMPGRKDVMLRALAHVNPSHLLDPKLFDFSALAVTGASPEERREASPP
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_STAAN
Sequence: MITLYNTLTRQKEVFKPIEPGKVKMYVCGPTVYNYIHIGNARPAINYDVVRRYFEYQGYNVEYVSNFTDVDDKLIKRSQELNQSVPEIAEKYIAAFHEDVGALNVRKATSNPRVMDHMDDIIQFIKDLVDQGYAYESGGDVYFRTRKFEGYGKLSHQSIDDLKVGARIDAGEHKEDALDFTLWKKAKPGEISWNSPFGEGRPGWHIECSVMAFHELGPTIDIHAGGSDLQFPHHENEIAQSEAHNHAPFANYWMHNGFINIDNEKMSKSLGNFILVHDIIKEVDPDVLRFFMISVHYRSPINYNLELVESARSGLERIRNSYQLIEERAQIATNIENQQTYIDQIDAILNRFETVMNDDFNTANAITAWYDLAKLANKYVLENTTSTEVIDKFKAVYQIFSDVLGVPLKSKNADELLDEDVEKLIEERNEARKNKDFARADEIRDMLKSQNIILEDTPQGVRFKRG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACASE_CAEEL
Sequence: MESSSINRWFEYESGHAWCESAYKYQTLPYVAEFANTCTNLPIIVLPLVNIMLLRRYLHDVNGGLIFPQLLLTFNGLASTYYHATLNLFGQLVDELSLVWIITVFLVVYIPVMKWFPEKFSKRLTLVRWVVLIVTALVSGLCFLEPNLNAIALMLFSIPAAVVINYEGKQSGIPDIESFPSRILALWGVAFSFWFADRLLCDFWLYLGTPYLHALFHLLAGLAGYTIFIMFSMIDIESRTKTHKYTAAVRYFPGKNGSIFSFPYISLKERSQ
What is the function of this protein?
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
What are the official names of this protein?
Alkaline ceramidase, AlkCDase, Alkaline N-acylsphingosine amidohydrolase, Alkaline acylsphingosine deacylase.
What is the protein family that this protein belongs to?
Belongs to the alkaline ceramidase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CSPF_ECOLI
Sequence: MSRKMTGIVKTFDGKSGKGLITPSDGRIDVQLHVSALNLRDAEEITTGLRVEFCRINGLRGPSAANVYLS
What are the official names of this protein?
Cold shock-like protein CspF, CSP-F.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTS32_CAEEL
Sequence: MWWTSLVFSVLLFDLIFISNCDYIHLPGNSDIPDLKLQSGYLNANENGTQKMFYFLLEARDIPVGEASLIIWFNGGPGCSSLSAFFEEFGPLYVNFGGKSLFENVHSWYHKANILFLESPIGVGFSYDTEQSNFTKVNDDSIAEQNFNSVIDFFQRKHSSYVNHDFFIAAESYGGVYGPMLSALVVDSISKREFPNENFKGLIIGNGFMNVKLSTNTMILWSAYHDRTSPDEWDEIKEKCATSGAHDVDYYDFMQFMKTTNKMDYLADNSTECGRLIEPLLGQFSETFDGYDFFNYYHDCYTNFSIPNATDPIKETLAQIPRRRISALFNKHSTDGQASYRCWADDALHKYLNLKEVQNALGIDRAWKDRKKKWEVCNMPIYDQYVMTHQDMTPFFSKIFDKFTGPAFRVLIYSGDIDTACNYLADGYFVRDLASIHGFKKTLKHGPWYHSEHKVIAGNFMRYEGANHLGSKLSIDVVTVKGSGHFVPLDRPGPALQMVHNFLTGKPGKMTNYTSPV
What are the official names of this protein?
Serine carboxypeptidase ctsa-3.2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
Protein: LPTN_ECOLI
Sequence: MNILHICVTSKWFNIDNKIVDHRP
What is the function of this protein?
Required for tryptophan-regulated expression of the tna operon.  In the presence of free L-Trp release of this nascent peptide by release factor 2 is inhibited and the ribosome stalls with the last amino acid in the P site and a UGA stop codon in the A site.  This prevent transcripiton termination factor Rho binding, and thus allows transcription and translation of TnaA and TnaB.
What are the official names of this protein?
Tryptophanase operon leader peptide.
Protein: CY550_SYNJB
Sequence: MFSKAFSFQKVFAPARRRLLVLLLAALMAGFGWGLAPVFAARDIPAVALSPTESITFTEAQLAKGKKLFNTACAQCHVGGQTYPNPDVSLKLSDLEGATPPRDNVLAIVDYIKNPVTYDGVESLLEYHPNTQLTSEYPRLRNLTDEDLKLIAGYILVQAKTVPGWGGTKNESHSDLSAYL
What is the function of this protein?
Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II.
What are the official names of this protein?
Cytochrome c-550, Cytochrome c550, Low-potential cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PsbV subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with photosystem II at the lumenal side of the thylakoid membrane.
Protein: MEP5_ARTGP
Sequence: MHGLLLAAGLLSLPLHVLAHPQPSTTTSLAGRAGTVDLNEFRMAHRSSYTGNDEMMKQPSIASFRQGTYLEVATELVKQTMPNMEFRLVDDHYVGDSGIGHVRFRQTMHGIDIDNSDFNVNIGKDGKVLSHGNSFYTGPAPSSNPMVKRDFMDPMQALHGVRKALKLPIKADGATVQDMSEHKVMFKGTSGALSDPTAKLCYMAKEDGSLALTWRVETDIGDNWLLSYMDAKESAKVHNVVDYVAHATFQVYKWGLADPTEGNREILNNPWNLKTSPLTWLADGQNNFTATRGNNAIAQYNPDGGNDYENNYRPSPKNLKFEYPYSANMDPPKTYIDASVTQLFYTSNVCHDLYYMLGFTEKAGNFQVNNRGQGGKGGDYVILNAQDGSGTNNANFATPPDGQPGRMRAYIWTRANPPRDASFEAGTVIHEYTHGLSNRLCGGPANSRCLNAIESGGMGEGWGDFYATAIRLKPKDTRKTNYVKGGWVNNSPKGVRMYPYSTDMSVNPLVYTSNNKLNEVHAIGTVWCSMLYEVLWNLIDKHGKNDGPVPVFENGVPKDGKYLAMKIVMDAWPCIQPCNPNFVQARDAILDADKNLTKGANKCEIWKGFAKRGLGVGAKYDPKNRTGSNEVPKEYKYSAHME
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates and probably acts as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 5, Elastinolytic metalloproteinase MEP5, Fungalysin MEP5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TCPB_CAEEL
Sequence: MLPVQILKDNAQEERGESARLSSFVGAIAIGDLVKSTLGPKGMDKILISGNPESAGGIKVTNDGATILKSIGVDNPAAKVLVDMSMTQDHEVGDGTTSVTVLAAELLKEAEKLVNQRIHPQTIISGYRRALGIAQESLKKSSIESGDNIRDDLLKIARTTLGSKILSQHKEHFAQLAVDAVLRLKGSGNLDAIQIIKKLGGSMNESYLDEGFLLEKLPGMFQPRRVEKAKILIANTPMDTDKVKVFGSRVRVDGVAKVAELEAAEKLKMKEKVDKILAHNCNVFINRQLIYNYPEQLFADAKVMAIEHADFEGIERLALVLGGEIVSTFDSPQTAQFGSCDLIEEIMIGEDRLLRFSGVKLGEACSVVLRGATQQILDESERSLHDALCVLVTHVKESKTVAGAGASEILMSSAIAVEAQKVAGKEALAVEAFGRALAQLPTIICDNAGLDSAELVTRLRAEHANGRHNMGIDIEKGEVADVTKLGVIESYNVKLCMVSSAAEATEQILRVDDIIKAAPRARAQDNRPC
What is the function of this protein?
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.  Known to play a role, in vitro, in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLD_CORGL
Sequence: MTQPGQTTTTSHEAIDAFKRIVGDEHVLTSERATMPFSKGYRFGGGPVFAVVRPGTLVEMWRALQVSVDNNLIVIPQASNTGLTGGSGPGFQDYDRPIVIISTHRIDEVHLINDAREAISLAGTPLTHLTDALAKHQREPHSVIGSTSIGASVIGGIANNSGGSQIRKGPAFTREAIFARVNDDGKVELVNHLGISLGDDPEVALDRLQRGEWSPEDVTPAPEDSNETEYAEHLRKIVPSPARYNANPEYLFEASGSAGKLMVFAVRTRTFPREVHPTVFYIGTNNTHELEEIRRLFLEADMPLPISGEYMGRSAFDLAEKYGKDTFVFLKFMSPALQTRMFSFKTWANGLFSKIPGIGPTFADTVSQAMFSVLPNQLPKRMMEYRNRFEHHLLLTVSESQKAASEKMLKEFFAEPEHTGEFFICTSDEEKSASLNRFGAASAATRYAALKRRHIAGLIPIDVALRRDDWNWLEVLPEEIDDQLEVKAYYGHFFCHVMHQDYVAKQGVDLEALHDRIQHLLEERGAKLPAEHNYGRIYKLPESMEEHFKELDPTNTFNAGIGGTSPHKDWA
What is the function of this protein?
Catalyzes the oxidation of D-lactate to pyruvate.  Has also weak activity with L-lactate and DL-2-hydroxybutyrate.  Electrons derived from D-lactate oxidation enter the electron transport chain.  Essential for growth with D-lactate as sole carbon and energy source.
What are the official names of this protein?
Quinone-dependent D-lactate dehydrogenase, D-lactate dehydrogenase, D-LDH.
What is the protein family that this protein belongs to?
Belongs to the quinone-dependent D-lactate dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RLMC_YERPS
Sequence: MHCAQYTAGRCRSCQWLDKPYPQQLADKQHHLESLLAGHAVTQWLAPVFGRESTFRNKAKMVVSGSVERPLLGMLHRDGTPVDLCACPLYPPSFEPVFTVLKTFIARAGLTPYNVARKRGELKFLLLTESTYNGELMLRFVLRSETKLAQLIAALPWLQQQLPQLAVISANIQPVHMAILEGEREIPLTEQQALPERFNQVPLYIRPQSFFQTNPPVAASLYATARQWVQEHEVHSMWDLFCGVGGFGLHCAGPETQLTGIEISAEAIACARQSAEQLGLKNVSFAALDSTRFATAEAQIPELVLVNPPRRGIGRELCDYLSQMAPKFILYSSCNAETMAKDISLLAGYHIERVQLFDMFPHTSHYEVLTLLALRR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: OPGH_SHEB5
Sequence: MTVSENSVLETEVLVGGSAMPNERPGAMEPQKLSKMPEGFPRRSTVANGVRSRASRRFLVVGGALLLSLFAIYEMGAVFSIGGITPLEYLVLALFAVNFCWIALAFCSGIAGFLILLRKPRAKDLQVTELHTRTAILMPTYNESPDRVFSAVSVMAETLSQTGHGHAFDWFILSDTTDPDIALLEEQAFLVLRQETHKHSRVYYRRRRKNVARKAGNVADFCRRWGSRYDHLLVLDADSLMESSTITGLAQRMQADPDAGLIQTIPSLINGTTLMARLQQFAARIYGPVIGTGLGWWVQKEGNFWGHNAIIRTEAFMTAAGLPNLKGKPPFGGHIMSHDFVEAALIRRAGWSVVIAYDLPGSYEECPPSIIDLAVRDRRWCQGNLQHSRILPTKGLHWVSRLHLLTGIMAYLSSPFWLMLILTGLMLALQAHFIRPEYFTDQFSLFPTWPIMDSDRALRLFYITMGVLFGPKVFGVLLLLKDGEFARSVGGRIKAIFSVIFEVILSALIAPIMMFIHCGAVMSILMGRDSGWSPQRRDDGSMPWMTLIYRHRWHMLAGVMLGYAAILDSLTLLAWMSPALIGLWIAVPISAWTGSVKIGEVFKRAGILATPEERNPAQICLQAHEARAAYQKHIAEPWTLAQVLKDPALMELHLAMVDKQPLRAAGTPIEAMEAIVHVKVHEARCQQSALAVLNRQEMAMVLANPLMLRSLQKLPEQFVEEDLVSFC
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis glucosyltransferase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. OpgH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL2_PROA2
Sequence: MAIRKLRPVTPASRYLSYPEFDEITKSEPEKSLLAPLKKSGGRNKAGRITSRHRGGGHKRFYRIIDFKRNKDNIPATVAAIEYDPNRSARIALLHYVDGEKRYILAPKGLKVGEQLLSGDKVEVKPGNTMPLKNIPLGTDIHNIEMKAGKGGQIVRSAGAYAVLAAKEGDYATLKLPSGEIRKVRIECRATIGGVGNADHENIVLGKAGRSRWLGVRPQTRGMAMNPVDHPMGGGEGKSKSGGGRKHPKSPWGQLAKGLKTRNKKKASSKLIVRGRKSK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: GLYA_ACIBC
Sequence: MFANISISEFDPELAQAIASEDERQEAHIELIASENYCSPAVMEAQGSKLTNKYAEGYPGKRYYGGCEFVDVIEQMAIDRAKELFGADYANVQPHAGSQANSAVYLALLNPGDTVLGMSLAHGGHLTHGAKVSFSGKTYNAVQYGLNAETGEIDYEEVERLALEHKPRMIVAGFSAYSRVVDWQRFRDIADKVGAYLFVDMAHVAGLVAAGVYPNPVQIADVTTTTTHKTLRGPRSGLILAKANEEIEKKLQSAVFPGNQGGPLMHAIAAKAICFKEAMSDDFKAYQQQVVKNAQAMAEVFIARGYDVVSGGTDNHLFLLSLIKQDVTGKDADAWLGAAHITVNKNSVPNDPRSPFVTSGIRIGTPAVTTRGFGEAEVRELAGWIADVIDSKGDEKVIADVKAKVEAVCAKFPVYAK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_PARPJ
Sequence: MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAESRPYSRATTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTGVYQLPKDKLWVTVYHEDDEAHDIWAKEVGVPVERIIRIGDNKGARYASDNFWQMADVGPCGPCSEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFSRDAQGNMTPLPKQCVDTGMGLERIAAVLQHVHSNYEIDLFQALIKAAGRETGVSDLTNNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKLGKKGSFFHRMVADLVAQMGDAYPELKEAEQRVTDVLRQEEERFFETIEHGMSILESALADLEAKGGKTLDGELAFKLHDTYGFPLDLTADVCREREVTVDEAAFDEAMARQREQARAAGKFKMAQGLEYSGAKTTFHGYEEIVFDDAKVIALYVDGASVKEVRDGRQAVVVLDHTPFYAESGGQVGDQGVLANASVRFAVSDTLKVQADVVGHHGTLEQGTLKVGDVVKAEIDAVRRARTARNHSATHLMHKALREVLGSHVQQKGSLVDADKTRFDFAHNAPMTDEQIRRVEEIVNAEVLANAPGIVRVMPFDEAVKGGAMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGLFKIVMEGGVAAGIRRVEAITGDNAVRFVQDLDARINAAAAVLKAQPSELTQRITQVQDQVKSLEKELSALKSKMASSQGDELAGQAIEVGGVHVLAATLEGADVKTLRETVDKLKDKLKSAAIVLASVEGGKVSLIAGVTADASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPANLPAALAGVKGWVEGQL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_LEPIC
Sequence: MANLKLLLVGIGNPGQKYVHNRHNIGFVILDSLLDSSSVSYQTNSKYSLARTDEDGVTIFYLKPLEFMNLSGKSVAEIAKKNGISPENILIIHDEIDFEFGKLKLKGGGGHAGHNGLRNIVEKLGTNTFFRLRFGVGKPSITSEVPDYVLSNFLPNEKEKIPELVKVSLQKISDWIRERKNGFQKLSDNQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_NEIMB
Sequence: MALLNILQYPDERLHTVAKPVEQVDERIRKLIADMFETMYESRGIGLAATQVDVHERVVVMDLTEDRSEPRVFINPVIVEKDGETTYEEGCLSVPGIYDTVTRAERVKVEALNEKGEKFTLEADGLLAICVQHELDHLMGIVFVERLSQLKQGRIKTKLKKRQKHTI
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: DNAA_STRA5
Sequence: MTENEQLFWNRVLELSRSQIAPAAYEFFVLEARLLKIEHQTAVITLDNIEMKKLFWEQNLGPVILTAGFEIFNAEITANYVSNDLHLQETSFSNYQQSSNEVNTLPIRKIDSNLKEKYTFANFVQGDENRWAVSASIAVADSPGTTYNPLFIWGGPGLGKTHLLNAIGNQVLRDNPNARVLYITAENFINEFVSHIRLDSMEELKEKFRNLDLLLIDDIQSLAKKTLGGTQEEFFNTFNALHTNDKQIVLTSDRNPNQLNDLEERLVTRFSWGLPVNITPPDFETRVAILTNKIQEYPYDFPQDTIEYLAGEFDSNVRELEGALKNISLVADFKHAKTITVDIAAEAIRARKNDGPIVTVIPIEEIQIQVGKFYGVTVKEIKATKRTQDIVLARQVAMYLAREMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMVAQDDNLRIEIETIKNKIR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRS7C_MOUSE
Sequence: MGLMAVLMLPLLLLGISGLLFIYQEASRLWSKSAVQNKVVVITDAISGLGKECARVFHAGGARLVLCGKNWEGLESLYATLTSVADPSKTFTPKLVLLDLSDISCVQDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKVLLPNMISRRTGQIVLVNNIQAKFGIPFRTAYAASKHAVMGFFDCLRAEVEEYDVVVSTVSPTFIRSYRASPEQRNWETSICKFFCRKLAYGVHPVEVAEEVMRTVRRKKQEVFMANPVPKAAVFIRTFFPEFFFAVVACGVKEKLNVPEEG
What is the function of this protein?
NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal (PubMed:21995425).  Plays a role in the regulation of cardiac and skeletal muscle metabolic functions (PubMed:21995425, PubMed:27806939, PubMed:29330505) (Probable).  Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal (PubMed:21995425).  Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes (PubMed:27806939).  Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid (PubMed:29330505).
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 7C, Sarcoplasmic reticulum protein of 35 kDa, Protein SRP-35, Short-chain dehydrogenase/reductase family 32C member 2, Protein SDR32C2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane. Note=The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. In skeletal muscle, enriched in the longitudinal sarcoplasmic reticulum (PubMed:21995425).
Protein: HSAA_RHOJR
Sequence: MQRLDALLPTLRERAQETEDLRRIPDDSMKALQETGFFRLLQPEQWGGYQADPVLFYSAVRKIASACGSTGWVSSIIGVHNWHLALFSQQAQEDVWGNDTDVRISSSYAPMGAGQVVDGGYTVNGAWAWSSGCDHASWAVLGGPVIKDGRPVDFVSFLIPREDYRIDDVWNVVGLRGTGSNTVVVEDVFVPTHRVLSFKAMSNLTAPGLERNTAPVYKMPWGTIHPTTISAPIVGMAYGAYDAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEASSDIDAAWRQLSGNVADEYALLVAGEEVPFELRLRARRDQVRATGRAISSIDKLFESSGATALANGTPLQRFWRDAHAGRVHAANDPERAYVMYGTGEFGLPITDTMV
What is the function of this protein?
Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol.
What are the official names of this protein?
Flavin-dependent monooxygenase, oxygenase subunit HsaA, 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, oxygenase subunit, 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the HpaH/HsaA monooxygenase family.
Protein: TRHBN_NOSCO
Sequence: MSTLYDNIGGQPAIEQVVDELHKRIATDSLLAPVFAGTDMVKQRNHLVAFLAQIFEGPKQYGGRPMDKTHAGLNLQQPHFDAIAKHLGERMAVRGVSAENTKAALDRVTNMKGAILNK
What are the official names of this protein?
Group 1 truncated hemoglobin GlbN, Truncated Hb, Cyanoglobin.
What is the protein family that this protein belongs to?
Belongs to the truncated hemoglobin family. Group I subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: RL30_XYLF2
Sequence: MVHEYDKTLKVCLVRSLIGVPSRHRLSVRALGLSKVSDMRKVNDTPQVRGLINKVHYLVRIQD
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.