PharMolix/UniProtQA huggingface dataset:
Protein: DCUP_XANAC
Sequence: MLKNDRLLRALNRQPVDRTPVWLMRQAGRYLPEYRATRARAGSFLGMAKNPDIACEVTLQPLQRFPLDAAILFSDILTIPDAMGLELYFVEGEGPKFRHPVRDAAAIHRLGVPDMETELRYVMDAVRVIRRELDGSVPLIGFSGSPWTLACYMIEGGGSKEYARIKAMAFNAPELLHHLLNTVTDAVIAYLAAQRAAGAQALQVFDTWGGVLSPAMYREFSLPYLTRIARELERGDGAERTPLVLFGKGNGAYVADLAASGAEAVGVDWTISLADAAQRAGGRVALQGNLDPATLYGSPEAIRAEVGKTLDSYAQGNGGSREGHVFNLGHGMSPDMNPEHVGVLVEAVQTLSKR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_ECOLI
Sequence: MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
What is the function of this protein?
Cell wall formation (PubMed:1512209).  Adds enolpyruvyl to UDP-N-acetylglucosamine (PubMed:1512209, PubMed:20392080).  Target for the antibiotic fosfomycin.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCHL_RHOP2
Sequence: MNILTDPLKLKTSGCADANASKCAEGDGEGSVQVQLDPNVKIGSAKVFSIYGKGGIGKSTTSSNLSVAFSKLGKRVLQIGCDPKHDSTFTLTKRLIPTVIDVLEEVNFHSEELRPEDFVFEGYNGVMCLEAGGPPAGTGCGGYVVGQTVKLLKEHHLLEDTDVVIFDVLGDVVCGGFAAPLQHSERAMIVAANDFDSIFAANRIAAAIQAKSKNYGVRLAGIIANRSRETDQIDKFGAATGIQRVAHLPDLDVIRKSRLKKMTLFEMDHTDEILAVQQEYLRLATEMWEAKTPPVQGKPLKDRDIFDLLGFD
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: LPXA_FUSNN
Sequence: MVDIHSTAIIEDGAIIEDGVKIGPYCIVGKDVVIKKGTVLQSHVVVEGITEIGENNTIYSFVSIGKDNQDLKYKGEPTKTIIGNNNSIREFVTIHRGTDDRWETRIGNGNLIMAYVHVAHDVIIGDDCIFSNNVTLAGHVVIDSHAIIGGLTPIHQFTRIGSYSMIGGASAVSQDVCPFVLAAGNTVVLRGLNIVGLRRRGFSDEEISNLKKAYRILFRQGLQLKDALEELEKDFSEDKNVKYLVDFIKSSDRGIAR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDC5_ENCCU
Sequence: MSTKVELYMEIGTVITDLEYHTKYMLKKLLGRGAYAQCYLAEIESGEQYAMKVVRLKDIKSRKVHEKLESEIAIHSKLDNPNVVKMYRSFRSSEYVFMVLELCERGALDALLKRNGKLKERHVARFVKQTVEGLIYLHNSVSVVHRDLKLGNLFLDSKFNVKIGDFGLSAVIKDGEKKVTMCGTPNYIAPEVLFGKASGHSFEADIWSLGVIIYTLLVGVPPFQKKNVEDIYKMIKLNNYIFPENCDLSSEAIDLITQILNTNPLERPTLEHILSHKFLSKKEHFLMKIYRNLMTNRTEEGVVDTDYVLFSIPVTKLRGVGYVLKSGVYGIYFSDHRNLMLKPNRKSVIYLNSTIESGKRVFYKEEHLVEKIPAEIAESYKGLQYFIRTFDNGFSFLDVEPCFIVKIRKIECGFLFVMADSTIVFDFVDGWRVVLSRCGERVSCYNGLGLASFNQEIRGRCIEILRGCLGCG
What is the function of this protein?
Protein kinase required for the cell cycle where it is involved in mitotic exit.  Required to form a bipolar spindle, the actin ring and septum.  Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes).  Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division (By similarity).
What are the official names of this protein?
Probable cell cycle serine/threonine-protein kinase CDC5 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: PA2AG_TRIST
Sequence: SLIQFETLIMKVAGQSGMFSYSA
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows a moderate inhibition of ADP-induced human platelet aggregation when tested on platelet rich plasma.  Exhibits moderate hydrolytic activities and prefers the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 CTs-A1, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TI214_SELUN
Sequence: MQKWASHLCAPQVPLSLWIRSSGPPILLGLYCGFAATLPTGPFHVPSVRASVSGREGVSGRSVASSSVTGQPVIIPSAYSPHFHVVSVKPHAVTSSAPPCISLYWYRHRVGIEAPRTAEPRAVTAIGWAYAAVASRDTEVWVRRSTLLDIIILPLPHHVPVLSPALARLVRLFVLRHSNQFLLVISSLRGWSGGSIPLEYLATPLVVPKIDPTDDGPSEPPVEPPAEASTTHRVPGTIVTALRLLCLGRAPLPVLFRETRHEPQRSSGGGDQEDFSWLNAWPASAFDYQKGVRPFRYVTDGYNPGSSVKKELSQYHFCTVVGPRKQTLSLSSPPGLSIPDDNSDKSVNLSLLPTTHKEPPPCREWIRTGGRKESDSNNDSMNRTEAPREGYSLVKVVDSNNGLYDHGESVPAEIHDPSISNGSRGRIVGFRSTRLSTRRKSGRRTASNSFRNSPGAPVEEGRNTGNHHREHPLLFVDATRRNSYSSLVTRVLRTHDMIRLLCIIIEHKQTFRWILNVVNDLLSVGSSDNSDDAYAADGANDAATGGGDDTDDDADDDANAAGYIRSMKVRNVEYAVNERTGNLRVLKRPVLQPDYRRNLIAGLMRARRRKTLVWESLQSRTHSPLFLRMIGNSAPPQFSPGINAKAILTPHRSAAEEEDNKAKPVFRRSAKMATAKRIAAAKRWDFTTAHLTRGCSPIAQLYLRRNVILPTLTIFRNICYLIMFQKGEWGEDWNELNKEVYVGRSYDGNAAEVAKGLPRRWYRNGLQIKIVNPFYLKHRRHFVYGQSEPDDGTGINSTGTRNGMSKSISSYETNSYGNSSSAGGGMGFGHSTVLGCLAESPLGDRIKRPSFWKPLLMELGRVWWGNVPWIRKTHIENLPSRPAGKDPSPVGKADGLDAGTGKSIGDRVAGTRPGECGAHSAKVGGGISDLSIEFMPERDCPLAVSDQSEYRARMSTGELGCLVARGNDGASRVTGEFAGAGKAIAPFGPTGQDRGYTGGSGTAAPILIHRIVVRARGRCLRLLRVSTCFVQIPFSGFHGAAAPICRFLPVWFNIRLITRSTRRYVSKVRRARDLLAGRGGGDSIGVYSSRRDVRVISQAYVLSRAWRLSAVNKFRPADPEYGRGNPGARKSTAHLGVGGQGILGKRPLRALGGRYEWARDPRRYNVPSGIWCRIAPRGRKMKDEYPRMKDRELNKKQSMTLDEAICLRGIDPEPAAGVERSRKIDRQYGSNPPSKSSPDVVPDSSEIRGFAKPWRMGRGIIPNDRTRKHRERIVSGGGWDRPENRMNERKNLPFGSNIHSWLYIDIPERFHILEMPEFVATRYLGLACELNVSTASGYVCAGRGSARARVETEFREDRIEGRWDLGSKQVTVRARKMRDATNVPHAVFIGSNIEYPREGSVESTCESMSRDMAPPPYHAAPPDSTNGMLDGNRGHRATGVDKRFLKHKMLSVLPNFQNRFRGILDFIAYYEKSVPPRTGILEDGGDKTICPHSSHIGDVPLPKRRAGSRILESFYLAEGRSRGARSEGGTVEGHERRDEEPPVQNRNAEENETQTINSILRPGHRPEDPSRMNRPRFCTNNGSQFAAARVRIYPSAGIFMT
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: ACCD_RHOP5
Sequence: MNWLTNVVRPKIRNILRRETPENLWIKCPDSGHLVFYKDVEANQFVIPGSNYHMRMGAVARLKSVFDGETWYDIALPEVTADPLKFRDERRYVDRIKDARAKTGLHDAVKVGYGKLENFPVVIAVQDFDFMGGSLGMAAGEAIVRGMELALEKRAPFILFAASGGARMQEGILSLMQMPRTTVGVQMLREAKLPYIVVLTNPTTGGVTASYAMLGDVQLAEPGALIGFAGARVIEQTIREKLPEGFQRAEYLRDHGMVDIVVHRHDLRSTLARLCRILTKSPAAEIEVVTPEPEPVAEAAVVLPAEAVAPPPAAEAAAPPATPPA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_ECO24
Sequence: MAKTLYEKLFDAHVVYEAENETPLLYIDRHLVHEVTSPQAFDGLRAHGRPVRQPGKTFATMDHNVSTQTKDINACGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGKDFDDAVAYWKTLQTDEGATFDTVVTLQAEEISPQVTWGTNLGQVISVNDNIPDPASFADPVERASAEKALAYMGLKPGIPLTEVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: AQP8_MOUSE
Sequence: MSGEQTPMCSMDLPEVKVKTSMAGRCRVFWYEQYVQPCIVELVGSALFIFIGCLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTVIGGLKTMLLIPYWISQLFGGLIGAALAKVVSPEERFWNASGAAFAIVQEQEQVAEALGIEIILTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVIVDILAGGSISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLLIGDEKTRLILKSR
What is the function of this protein?
Channel that allows the facilitated permeation of water and uncharged molecules, such as hydrogen peroxide and the neutral form of ammonia (NH3), through cellular membranes such as plasma membrane, inner mitochondrial membrane and endoplasmic reticulum membrane of several tissues (PubMed:27256569, PubMed:9388476, PubMed:15647389, PubMed:15948717, PubMed:16624991, PubMed:21117174).  The transport of ammonia neutral form induces a parallel transport of proton, at alkaline pH when the concentration of ammonia is high (By similarity).  However, it is unclear whether the transport of proton takes place via the aquaporin or via an endogenous pathway (By similarity).  Also, may transport ammonia analogs such as formamide and methylamine, a transport favourited at basic pH due to the increase of unprotonated (neutral) form, which is expected to favor diffusion (By similarity).  In vitro, may be also permeable to urea but not to glycerol (PubMed:9388476).  Does not transport urea or glycerol (By similarity).  The water transport mechanism is mercury- and copper-sensitive and passive in response to osmotic driving forces (PubMed:9388476).  At the canicular plasma membrane, mediates the osmotic transport of water toward the bile canaliculus and facilitates the cAMP-induced bile canalicular water secretion, a process involved in bile formation (By similarity).  In addition, mediates the hydrogen peroxide release from hepatocyte mitochondria that modulates the SREBF2-mediated cholesterol synthesis and facilitates the mitochondrial ammonia uptake which is metabolized into urea, mainly under glucagon stimulation (By similarity).  In B cells, transports the CYBB-generated hydrogen peroxide from the external leaflet of the plasma membrane to the cytosol to promote B cell activation and differentiation for signal amplification (PubMed:27256569).  In the small intestine and colon system, mediates water transport through mitochondria and apical membrane of epithelial cells (By similarity).  May play an important role in the adaptive response of proximal tubule cells to acidosis possibly facilitating mitochondrial ammonia transport (By similarity).
What are the official names of this protein?
Aquaporin-8, AQP-8.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y495_ALISL
Sequence: MKLMVVSGNSGAGKSVALRVLEDLGYYCVDNLPVDLLAQFVESIQHSSQNVAVSVDIRNLPKDPSLLKNTLTELKKSHDVTVIFLDAEDKELIKRYSETRRLHPLSLIGEQCSLEQAVELEKSILCHFKEDADLVLDTTSKSIHDLSETLRSRILGRESKELVMVFESFGFKHGLPTDADYVFDVRFLPNPHWEPTLRPMTGLDKPVADYLEKHAEVIQLKEQIQHFLMTWLPALEKNNRSYLTVAIGCTGGQHRSVYITQQLGEYFKQQGQQVQIRHKTLERH
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein VSAL_I0495.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: SYT_CARHZ
Sequence: MISLKFPNNEVREFPENITALEVAKTLSPRLAKEALCASINGKLIDLSQKISESGEFRLYTFEDDEGKDVFRHSSAHLMAQAVKRLFPKTKLAIGPAIKDGFYYDFDPEESFSPEDLEKIEAEMEKIVKEDLPIERFVLSRDEAIKFFEEKGEIYKVELVKDIPEGVEISFYRQGEFVDLCTGPHVPSTGYLKAFKLLNIAGAYWRGNEKNKMLQRIYGVSFPKKSMLTDYLNFLEEAKKRDHRKIGQELDLFSLQEEGPGFPFFHPKGMVIRNELENFWREKHRLAGYQEIKTPIILNRELWERSGHWAHYKENMYFTKIDDQDYAIKPMNCPGSILVYKNKLHSYREFPIRLAELGLVHRHELSGVLHGLMRVRCFTQDDAHIFMLPEQVKDEIIGVINLIDEFYRLFGFEYHVELSTRPENSMGSDELWELATNSLKEALEERGLPYKINEGDGAFYGPKIDFHLKDCLGRTWQCGTIQLDFQMPEKFDLTYIGEDGQKHRPVMIHRVVFGSIERFIGILIEHYAGAFPVWLSPVQVRVITVAERHREYGQEIYQKLFNQGVRVELDDRNETIGYKIREGQMQKIPYLLIVGDKEIEQGSVAVRKRGVGDLGQKPFAEFIEELLAEIREKR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_ECO7I
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: THIC_GLOVI
Sequence: MLRTEWIARRHGHANVSQMYYARQGLITEEVAYVAHRENLEPELVRSEVARGRLIIPANTNHPNLEPMGIGIATRCKVNANIGASPNASNLGEEVAKLELAVKYGADTVMDLSTGGGDLDAIRSAIIQASPVPIGTVPMYQALEAVHGNVEKLTPEHILDVIEKHAKQGVDYMTIHAGILIEHLPLTQGRLTGIVSRGGGILARWMLAHHKQNPLYTHFDEIINIFKKYDVSFSLGDSLRPGCQHDASDAAQFAELKTLGELTRRAWTHDVQVMVEGPGHVPMHQIEMNVRKQMQECSEAPFYVLGPLVTDIAPGYDHITSAIGAALAGWYGTAMLCYVTPKEHLGLPNAEDVRTGLIAYKIAAHAADIARGRPGARDRDDELSRARYNFDWNRQFELSLDPERAREYHDETLPADIYKSAEFCSMCGPKFCPMQTKIDSQALSELEAALKPQPVAAQE
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: LPXA_SINMW
Sequence: MIASSAKIHPSSAIEGGAVIGENVKIGPFCHIGPNVVLADEVEILSHVTVIGRTTVGKGTKIFPGAVIGGDSQSMHHSALNTTLVIGENCTIREGVTMNTGTVEHGGATIVGDNNLFLAYSHVAHDCRLGNNIILSNNVMLAGHVTVADRAILGGGSAVHQFTRIGRQAFIGGLSAVSYDVIPYGMLNGNPGLLSGLNVVGMTRAGFDRSTIHRVRRCYKQIFEGDGSIRANAAAIRDEYLDCAPALEILDFIAAESDRALSSPNRGAKG
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_PROMT
Sequence: MPPRPRFDRRAPERELPNINERISYSSLRVVDSDGTQLGVISREDALEVAKERELDLVLVSEKATPPVCRIMNYGKFKFEQEKKAKEAKKKSHQTEVKEVKMRYKIDQHDYQVRISQATRFLKAGDKVKCTVIFRGREIQHTALAETLLKRMAKDLEEKAEVQQSPKREGRNMIMFLTPRKTPLLKKESEITEPKKALRTID
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_XANOR
Sequence: MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEAVSTNNRMELMAAIMALETLTEPCEIVLHTDSQYVRQGITEWMPGWVRRNWKTAGGDPVKNRELWERLHAATQRHRIDWRWVKGHNGDPDNERVDVLARNQATAQRDGRATS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAT1_RAT
Sequence: MEETSPRRRREDEKSVHSTEPKTTSLQKEVGLLSGICIIVGTIIGSGIFISPKSVLANTESVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYLGCRPPAVVVKLLAAAAILLITTVNALSVRLGSYVQNVFTAAKLVIVAIIIISGLVLLAQGNVKNFQNSFEGSQTSVGSISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFTVMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVKRLTPAPALVFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILGLVVMRFTRKDLERPIKVPIFIPIIVILVSVFLILAPIISSPAWEYLYCVLFILSGLIFYFLFVHYKFRWAQKISRPITKHLQMLMEVVPPEKDPE
What is the function of this protein?
Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:10506124) (By similarity).  Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity).  Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (By similarity).  Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity).
What are the official names of this protein?
b(0,+)-type amino acid transporter 1, b(0,+)AT, Glycoprotein-associated amino acid transporter b0,+AT1, Solute carrier family 7 member 9.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: RBM8A_MOUSE
Sequence: MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEEGSRARMREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVEYETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRR
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome (By similarity).  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs.  Associates preferentially with mRNAs produced by splicing.  Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs.  Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity).
What are the official names of this protein?
RNA-binding protein 8A, RNA-binding motif protein 8A, Ribonucleoprotein RBM8A.
What is the protein family that this protein belongs to?
Belongs to the RBM8A family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
Protein: GABT_HUMAN
Sequence: MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
What is the function of this protein?
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998).  Can also convert delta-aminovalerate and beta-alanine (By similarity).
What are the official names of this protein?
4-aminobutyrate aminotransferase, mitochondrial, (S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, GABA-AT, Gamma-amino-N-butyrate transaminase, GABA transaminase, GABA-T, L-AIBAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: MRAY_STRPN
Sequence: MFISISAGIVTFLLTLVEIPAFIQFYRKAQITGQQMHEDVKQHQAKAGTPTMGGLVFLITSVLVAFFFALFSSQFSNNVGMILFILVLYGLVGFLDDFLKVFRKINEGLNPKQKLALQLLGGVIFYLFYERGGDILSVFGYPVHLGFFYIFFALFWLVGFSNAVNLTDGVDGLASISVVISLSAYGVIAYVQGQMDILLVILAMIGGLLGFFIFNHKPAKVFMGDVGSLALGGMLAAISMALHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKRIFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLTLAILYLM
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.