PharMolix/UniProtQA huggingface dataset:
Protein: ABHD6_HUMAN
Sequence: MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
What is the function of this protein?
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151).  Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity).  Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).  Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015).  BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).
What are the official names of this protein?
Monoacylglycerol lipase ABHD6, 2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: MAD18_ORYSI
Sequence: MGRGPVQLRRIENKINRQVTFSKRRNGLLKKAHEISVLCDADVALIVFSTKGKLYEFSSHSSMEGILERYQRYSFDERAVLEPNTEDQENWGDEYGILKSKLDALQKSQRQLLGEQLDTLTIKELQQLEHQLEYSLKHIRSKKNQLLFESISELQKKEKSLKNQNNVLQKLMETEKEKNNAIINTNREEQNGATPSTSSPTPVTAPDPIPTTNNSQSQPRGSGESEAQPSPAQAGNSKLPPWMLRTSHT
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
MADS-box transcription factor 18, FDRMADS7, MADS-box protein 2, MADS-box protein 28, OsMADS18, OsMADS2, OsMADS28.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y343_METJA
Sequence: MDCMKKLKVEGTLELNLDDKDVRKNLKSLEKIKSKLEIESNINAVIKQLDELKNVKSEVEFKSNINMIIRELEEIEADASKMNINFDYDLSKLKSELEQLKNTKIDIKTNTDQILKQINKIKSELSEKQTIRAKVEVDRTEWDKLKKEWSEKYHINAIADVASVGTAYMGISDAEKYNELMTILRERGLTKDQAERLIQIGLYNGYSLDEIRDGIVYSNEAVLKLAASNDKYAAQILAAMAMAERGGEPGADDIARMISALTAMGKSNEEIMKMVNAEVLEMKQGHTEVAEAIREFSITMGDTLDPEKFASILIQAQAAGAQDVGQLAEAINDLALNSRQMGFDVEKALREIQKTKDDKTLAELAKKYGLTYEQIVKIHDYLQRVDLDKGLPDNTNELDRLISINKDQKGILETIKQDIEGWLAGHGYLQYGAELGVGLGGLGKILEIAIGAAIGSALKDAFGEIKSTLFGKISLDNLKLPELSKIKLPVDLEIPKIPKISMPKIKLPVDLKLPKIPKINIPKINLPNVSGLSNAFKGLGEAVRFAGRAFGFLSVVVEPVKQLLEGDIQGAIEHLKVGLIELAAWPVALGEALAAVTLAVGDFLGLFDLDGDSPLSAARAGILTLLAAFESIYSFITGDWSVVQNTLQEAFEELGMKEDEARQAAENLAQQWQQLPQQILDAFNGFVDNIKQTFDEWWNGLNEWWSQKIEEAKNWGSDLIQNIIDGIKEKFSELENAVSQAAGIISSYLHHTTPDVGPLKDDDKWGIHFMENIIGGIRKEIPNLKKTIDYTAKLMSSANPKNWKIQQVGITHSTSYSYGDIHINVVGNSFNEHQLAQKIALILKKQRFR
What are the official names of this protein?
Uncharacterized protein MJ0343.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YR338_MIMIV
Sequence: MSTQNIDISDLKYNIDVNDIEIIDPFIGENKTDDQKYSNPFFLDHNGSEQKFTKTNILADEYKYVYILCLCDDFELNESNINRVNLFFEKDSVVSELTSQTNSITLVQCPFEIIKIASIRSGVVVVNKDVLEYFNHDSVDLLSRELVYLMLQTKESNVRNWIKMYKSDNNLNKFIQQKIFSSYYGINDERFDHEMIKSLGEINDFRFWENPSNCEININEAFKSRRLNINSSSKWNIPESEIEKFLFDFKNVSGSFKSHKYPPGPPDNSSSNTSGQQNTSNTSNTKFKKFKQVFYKIVDANDMLIDKQDVEDLLISNCLSEREKYYLVCLLLSSKNYCHYILNNHKVITSISDIISKYKPIIRYLMGFAWMSLYLEERVKRSKSIESDRFVFDLENASKPPVFPYNPQNPYTNPYFVMTVSSDLLNLSNNVSGVKQSLEYQSGIVDITEFKKRLNLFISGSHEKDILEGANWNNMVITGGSMTAILPRRNPLHALFTKESKADITYEELNRFYQEYYSNSDIDVACNHENIIDFIENVKHIQTIIAKNLGVKDSEIKTDDIKTLAIYINPKLLQSKCSSGEIPYDYDYILKNKDAREIKFYFHELYIEKKKLSNNKNKKILGSRINDNNYFNIIRYCEIEKVTIIINDYSYESDQVDYKIPEQNSGLETVFYLKDNDTIFIKFSETIKYKIHSRHLKHQFEVFRITDKEFFSCIGRFHLPCVRSYYNGTTCYLLPSAITAYMTFTNMDFKYFIGSHDPLNIINKYRLRGYGTILNENELKYYVKYIHVIDKVKKSFNLKDTDNAEKTLGCLDVTNDFFKPKKFIPEEFPLGLESPSYKDNPDITYITEDTISKLYKQNYPKYLADFNQYTTILPNGNIGPLKRWLIDAAYDLLNN
What are the official names of this protein?
Uncharacterized protein R338.
Protein: ISPH_BRUSU
Sequence: MTQQRPPLEIRLCGPRGFCAGVDRAIQIVVLALKKYGAPVYVRHEIVHNRYVVEGLQARGAIFVEELDEIPAAHRNQPVVFSAHGVPKSVPADAEAKNLFYLDATCPLVSKVHKQAMRHQRLGRHVILIGHSGHPEVIGTMGQLPDGAVTLIETVEDAHTCHFDDEDNLGFVTQTTLSVDDTAGIIKELQARFPNLAAPAAESICYATTNRQDAVRAAAPGCDLFLIVGAPNSSNSKRLVEVAEKAGARMSMLVQRAEDIEWEQIGDISVVGLSAGASAPEIIVDEIIDAFKAHFDVKIELAETTVETENFLVNREIRDVELTVKDMAFVNGEHRVVGISKLMQGK
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PKNX1_BOVIN
Sequence: MMATQTLSIDSYPDGQQMQVVTELKTEQDPNCSEPDVEGVSPPPVGSQTPMDADKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTLSPQGIVVPASALQQGNVTMATVAGGTVYQPVTVVTPQGQVVTQALSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGAAQPAASELTVSEGAVVTITAPVSMNVDSLQSLSSDGATLAVQQVMMAEQSEDDSVDSTGDGGAALAPGHLGGLVLENSDSLQ
What is the function of this protein?
Activates transcription in the presence of PBX1A and HOXA1.
What are the official names of this protein?
Homeobox protein PKNOX1, PBX/knotted homeobox 1.
What is the protein family that this protein belongs to?
Belongs to the TALE/MEIS homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPH_BREBN
Sequence: MEVIKISPRGYCYGVVDAMVLALRTAQNFDLPRPIHILGMIVHNAHVVEAFEKQGIKTLDGEDRLALLDQVQEGTIIFTAHGVSPEVRKKARDKGLTVVDATCPDVTKTHDLIREKVAEGYHVLYIGKKGHPEPEGAMGIAPDHVHLVQKLEELEALDLPTDKLIVTNQTTMSQWDVKHLMDAILKRFPGVEVHNEICLATQVRQEAVAEQVGEADLCIVVGDPRSNNSNRLAQVSEEIADVPSYRIADLFELDIEWLRGKKNVAVTSGASTPTPLTKEVITFLEQFDEFNPATWEKKRTVNMAKILPTVK
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: GLMM_STRA1
Sequence: MGKYFGTDGVRGEANVELTPELAFKLGRFGGYVLSQHETDRPRVFVARDTRISGEMLESALIAGLLSVGIEVYKLGVLATPGVSYLVRTEKASAGVMISASHNPALDNGIKFFGSDGFKLDDDRELEIEALLDAKEDTLPRPSAQGLGTLVDYPEGLRKYEKFMESTGIDLEGMKVALDTANGAATASARNIFLDLNADISVIGDQPDGLNINDGVGSTHPEQLQSLVRENGSDIGLAFDGDSDRLIAVDENGEIVDGDKIMFIIGKYLSDKGQLAQNTIVTTVMSNLGFHKALDREGIHKAITAVGDRYVVEEMRKSGYNLGGEQSGHVIIMDYNTTGDGQLTAIQLTKVMKETGKKLSELASEVTIYPQKLVNIRVENNMKDKAMEVPAIAEIIAKMEEEMDGNGRILVRPSGTEPLLRVMAEAPTNEAVDYYVDTIADVVRTEIGLD
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RNH2_FRAAA
Sequence: MRPRGVVIRRDAGLFGYERALVRCGLGPVAGVDEAGRGACAGPLVVAAVVLGPDGRRRLSPRLADSKLLTEQVREGLFDEVLRAAADWSAVVIPAAEIDRTGVHVANITGMRRAVARLGHRPGYVLTDGFAVAGFGTESLAVVKGDRVAACIAAASIVAKVTRDRIMRALHTRYAEYDFAQHKGYVTAAHAAALARYGPCDEHRKSYVNVAAHAVPTREARSLRLEDRVLATSLHGVTETA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTA_SINFN
Sequence: MHQVEEIILIVENLAEVRGKTPHYRHLYVQVLAAIAVGILLGYFYPDVGSKMKPLGDAFIMLVKMIIAPVIFLTVATGIAGMTDLAKVGRVAGKAMIYFLTFSTLALLVGLVVANVVQPGAGMHIDPASLDAKAIATYAEKAHEQSVTGFLMNIIPTTLVGAFAEGDILQVLFISVLFGISLAIVGKKAEAVVDFLHALTLPIFRLVAILMKAAPIGAFGAMAFTIGKYGVASIANLAMLIGTFYLTSFLFVFMVLGAVARYNGFSIVALIRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATDTPISYGDQILLLLIAMLSSKGAAGITGAGFITLAATLSAVPSVPVAGMALILGIDRFMSECRAITNIIGNAVATIVVAKWEGELAPAQLATTLAGKAPVETMSGLSSQRSDTVELGQKVLFGATNSADRTLAGRPGGRDSRRIAPDHSAQVFGGPLSL
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane.  This transport system plays an essential role in the energy supply of tropical rhizobium-legume symbionts.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPB_PSEPG
Sequence: MRRIAVMGAAGRMGKTLIEAVQQTPGAGLTAAIDRPDSSLVGADAGELAALGRIGVLLSDDLAKVADEFDVLIDFTHPSVTLKNLAFCRKHGKAMIIGTTGFSVEEKQLLAEAGKDIPIVFAANFSVGVNLSLKLLDMAARVLGDDVDIEIIEAHHRHKVDAPSGTALRMGEVVANALGRNLQEVAVYGREGQTGARDRKTIGFATVRAGDVVGDHTVLFAAEGERLEITHKASSRMTFAKGAVRAALWLDGREPALYDMQDVLELR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDK_ECO57
Sequence: MTQQITLIKDKILSDNYFTLHNITYDLTRKDGEVIRHKREVYDRGNGATILLYNAKKKTVVLIRQFRVATWVNGNESGQLIETCAGLLDNDEPEVCIRKEAIEETGYEVGEVRKLFELYMSPGGVTELIHFFIAEYSDNQRANAGGGVEDEDIEVLELPFSQALEMIKTGEIRDGKTVLLLNYLQMSHLID
What is the function of this protein?
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
What are the official names of this protein?
GDP-mannose pyrophosphatase, GDP-mannose hydrolase, GDPMK.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudK subfamily.
Protein: RECR_ACIC5
Sequence: MTRFAEPMARLIEELRKLPGIGTRSAQRLAFHILRSSTADAEALAGAVRDLKAQLRLCSVCNNITDVDPCVFCSSPTRNQRLVCVVEEPTNIAAVEKTRGYNGVYHVLHGTLSPLHGVGPEHLRTVNLLARVERGEVDELILATSPTVEGEATANYLADLLRPLRVRLTRIATGVPAGSDIEYVDEVTMTRALEGRREL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: FLGI_PSEAE
Sequence: MTKFKHLLALAALLLAAGAAQAERLKDIASIQGVRTNQLIGYGLVVGLSGSGDQTTQTPFTLQTFNNMLAQFGIKVPANVGNVQLKNVAAVSVHADLPPFAKPGQPIDVTVSSIGNAKSLRGGSLLMTPLKGIDGQVYAVAQGNLVVGGFDAEGRDGSKITVNVPSAGRIPAGATVERAVPSGFDQGNSLTLNLNRPDFTTAKRIVDRINELLGPGVAHAVDGGSVRVSAPLDPNQRVDYLSILENLDVQPGEAVAKVIINSRTGTIVIGQNVKVSPAAVTHGSLTVSITEDPIVSQPGAFSNGQTAVVPRSRVNAEEETKPMFKFGPGTTLDDIVRAVNQVGAAPSDLMAILEALKQAGALQADLIVI
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: RPGR_HUMAN
Sequence: MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPDSFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVGNDTGQVGPQADTDGEGLQKEVYRHENNNGVDQLDAKEIEKESDGGHSQKESEAEEIDSEKETKLAEIAGMKDLREREKSTKKMSPFFGNLPDRGMNTESEENKDFVKKRESCKQDVIFDSERESVEKPDSYMEGASESQQGIADGFQQPEAIEFSSGEKEDDEVETDQNIRYGRKLIEQGNEKETKPIISKSMAKYDFKCDRLSEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYMLDDADSSSLEILENSETTPSKDMKKTKKIFLFKRVPSINQKIVKNNNEPLPEIKSIGDQIILKSDNKDADQNHMSQNHQNIPPTNTERRSKSCTIL
What is the function of this protein?
Could be a guanine-nucleotide releasing factor.  Plays a role in ciliogenesis.  Probably regulates cilia formation by regulating actin stress filaments and cell contractility.  Plays an important role in photoreceptor integrity.  May play a critical role in spermatogenesis and in intraflagellar transport processes (By similarity).  May be involved in microtubule organization and regulation of transport in primary cilia.
What are the official names of this protein?
X-linked retinitis pigmentosa GTPase regulator.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum axoneme. Golgi apparatus. Cell projection, cilium. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity). Colocalizes with WHRN in the photoreceptor connecting cilium (By similarity). Colocalizes with CEP290 in the photoreceptor connecting cilium (By similarity). Colocalizes with RPGRIP1 in the photoreceptor connecting cilium (By similarity). SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: KDM3A_MOUSE
Sequence: MVLTLGESWPVLVGKRFLSLSAAEGNEGGQDNWDLERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIDVYSLQRKAFLVEHNLVLAERKSPEVPEQVIQWPAIMYKSLLDKAGLGAITSVRFLGDQQSVFVSKDLLKPIQDVNSLRLSLTDNQTVSKEFQALIVKHLDESHLLQGDKNLVGSEVKIYSLDPSTQWFSATVVHGNPSSKTLQVNCEEIPALKIVDPALIHVEVVHDNFVTCGNSTRTGAVKRKSSENNGSSVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPSSKDPRQQNTPQAANSPPNIGAKLPQGCHKQNLPEELSSCLNTKPEVPRTKPDVCKEGLLSSKSSQVGAGDLKILSEPKGSCIQPKTNTDQESRLESAPQPVTGLPKECLPAKTSSKAELDIATTPELQKHLEHAASTSDDLSDKPEVKAGVTSLNSCAEKKVEPSHLGSQSQNLKETSVKVDNESCCTRSSNKTQTPPARKSVLTDPDKVRKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKDQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWIRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPALKEDLKQTSLSGEKPTLGTMVQQSSPVLEPVAVCGEAASKPASSVKPTCPTSTSPLNWLADLTSGNVNKENKEKQLTMPILKNEIKCLPPLPPLNKPSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTAKTENGLKNTPKILDDIFASLVQNKTSSDSSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNDKEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQDNPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSLGKP
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.  Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'.  Demethylation of Lys residue generates formaldehyde and succinate.  Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation (By similarity).  Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin (PubMed:17943087).  Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
What are the official names of this protein?
Lysine-specific demethylase 3A, JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A, [histone H3]-dimethyl-L-lysine(9) demethylase 3A.
What is the protein family that this protein belongs to?
Belongs to the JHDM2 histone demethylase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa.
Protein: CTAA_XANP2
Sequence: MPHVEAITLTRDRRGPGLGAVRLWLYAVAALIIAMVVVGGATRLTESGLSITEWKPVTGALPPLSQADWQAEFDKYQAIPQYEILNKGMGLEAFKRIYWWEWGHRLLGRLIGFAFLLPFLWFAWRGVLRGRLLAKCLVLFLLGGLQGAVGWWMVASGLTARVSVSQYRLAIHLTLACIILSAIVAVARSLSPEPRQVVGGRLRATAWALVALVLVQIFAGGLVAGLDAGMAFNTWPLMDGHLIPPAAQLAAADPFWRNLFENALTVQFNHRMIAYALWTLTLLHALDARRAGGAVAQRAWVLFALVTAQASLGILTLIHQVPIDLALAHQFGATLVLVVATLHLGGLSGQVEPATPKLRLVKG
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TBA2_MAIZE
Sequence: MRECISIHIGQAGIQVGNACWELYCLEHGIQADGQMPGDKTIGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVAILLDNEAIYDICRRSLDIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVNEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPSVVPGGDLAKVQRAVCMISNSTSVVEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEFDEGEEGDDGDEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-2 chain, Alpha-2-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: CX3C1_HUMAN
Sequence: MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKENECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMRKDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL
What is the function of this protein?
(Microbial infection) Acts as coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932).  May have more potent HIV-1 coreceptor activity than isoform 1 (PubMed:14607932).
What are the official names of this protein?
CX3C chemokine receptor 1, C-X3-C CKR-1, CX3CR1, Beta chemokine receptor-like 1, CMK-BRL-1, CMK-BRL1, Fractalkine receptor, G-protein coupled receptor 13, V28.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GPR1_YARLI
Sequence: MNTEIPDLEKQQIDHNSGSDDPQPIHDDMAPVSRIRSSGPNHEYIHIADQKFHRDDFYRAFGGTLNPGGAPQPSRKFGNPAPLGLSAFALTTLVFSLCTVQARGVPNPSIAVGLALFYGGVCQFAAGMWEFVQENTFGAAALTSYGGFWMSWAAIEMNAFGIKDSYNDPIEVQNAVGIYLFGWFIFTLMLTLCTLKSTVAFFGLFFMLMMTFLVLACANVTQHHGTAIGGGWLGIITAFFGFYNAYAGLANPGNSYIVPVPLDMPFVKKD
What is the function of this protein?
Plays a role in the adaptation of cell metabolism to the utilization of acetic acid, possibly by inhibiting an anion-transporting ATPase and affecting the plasma membrane H(+)-ATPase.  May be indirectly involved in the repression of genes encoding glyoxylate cycle enzymes.
What are the official names of this protein?
Glyoxylate pathway regulator.
What is the protein family that this protein belongs to?
Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: ELIA_PHYDR
Sequence: TTCTSTQQTAAYVTLVSILSDSSFNQCATDSGYSMLTATALPTDAQYKLMCSSTACNTMIKKIVSLNAPNCDLTVPTSGLVLNVYEYANGFSTKCASL
What is the function of this protein?
Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families.  Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins.  Might interact with the lipidic molecules of the plasma membrane.
What are the official names of this protein?
Alpha-elicitin DRE-alpha.
What is the protein family that this protein belongs to?
Belongs to the elicitin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TMCAL_LEUCK
Sequence: MKAVGLVTEYNPFHNGHIYHIQQAKAVTGADVVIAVMSGNFVQRGEPALFDKWTRTQAALANGVDLVIELPTFYAVQPSHLFAEGAIKLLTALGVEDVVFGSEHATVDFLNLAKQAPSVQGGKAFQEKNQTFAQAYATQLESETGFKLEDPNDILAFGYAKAILNLNSPIKLHAIQRVAAGYHDQSFTDDQTIASASSIRLALHKGKLEKVKGVVPNQTLVDISSANHTVDFESQFWPLLKYRLMTDTIGQLGQVYQMAEGLEHRLAAVALGEPGPQSYQSFIKAVKSKRYTFARIQRTLLYTLLNVKVDQMQAAMQDPYLRILGFTDKGQAYLNGAKKTTTLPLISKVDQHLAKANLRLDFKAGKLWQLLAREPGQQQDIARQPIHFTQAHTKEDK
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_SYNFM
Sequence: MPRVPITKEGFERLKIELQRLQRDERPMVIRAIEEARSHGDISENAEYEAAKEKQAMIEGRIQDLCQKMGECEIVEPSDNDNGRAIFGSTVVVEDTETGEVTSYRLVGPYEADVQSGTISVVSPLGKALIGKEEGEEIRVQTPKGVRNIEVLEIRN
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: Y1371_METJA
Sequence: MIIMYAIGIGDNKEEVLKAYEKLKEEGIEVELIDNPKLLVDKLLDGEIDGAVRGSLSSSKVILYLRERIGKFYRASILKNPFTNGIFLLSPVGIDDISEDKNERIKDKIRIIEFASNFLKNYNIKAKVAVLSGGRLGDLGRNKVVDETIYEAEEIVEHFKGNVDIIHNGILIEEYLKDGYNIIIAVDGITGNLIFRCLGLICKIPGYGAVILSDKNVNFIDTSRNANWERYYNAIKFLIGGDFG
What are the official names of this protein?
Uncharacterized methyltransferase MJ1371.
What is the protein family that this protein belongs to?
Belongs to the MtxX family.