PharMolix/UniProtQA huggingface dataset:
Protein: RS4_ALKEH
Sequence: MARYIGPTCKLARREGTDLFLKSGVRPLDSKCKLDQPPGPKLQRRTRMSDYGLQLREKQKVRRMYGVLERQFRNYYKEAARQKGATGTVLLQLLESRLDNVVYRMGFATTRAEARQLVSHRGVQVNGRVVNVPSMQVSPGDLVGLKEKAQKQLRVQAALEMAQQNGWPAWVEVDPKKFEGTYKARPDRADLSAEINESLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: T61_TERGU
Sequence: MRPFLVFVLIVSVSLAFSFEDMPNKGGDSVASITADQARGHKRNPLFPFAQRSLTELKAGGCPLYCSSQIFCCHGRKCRNVDGRLKCVTEASMLGK
What is the function of this protein?
The recombinant protein causes paralysis to polychaete worms (Nereis virens), the natural prey of terebrid snails.
What are the official names of this protein?
Teretoxin Tgu6.1, Teretoxin peptide 6.1.
What are the subcellular locations of this protein?
Secreted.
Protein: DPAL_SALTY
Sequence: MHELIKYQFNTRRKKYGTGAALSLLNGNVGHEVLAFHKKLPNYAVTPLHNLAHLSQRLGLGSIHIKDESWRFGLNAFKGLGGSYAVGKYLADKLQCDINSLSFAALNTPEIKEKIKDCVFVTATDGNHGRGVAWAAEQLGLKAVVYMPKGSSLIRAENIRHHGAECTITDLNYDDAVRLAHRMAQTKGWVLLQDTAWTGYEEIPTWIMQGYMTLAVEAYEQLAETNSPLPTHLILQAGVGSFAGSVMGYFVEKMQENIPNIIVVEPHQANCLYQSAVMDDGQPHCVTGDMATIMAGLACGEPNIISWPIIRDNTSCFISADDCLAAKGMRISAAPRPGTDTPFISGESGAIGVGLLYELMNNMHYQDLANRLQLDASAHVLLISTEGDTSPDIYEDIVWNGRSA
What is the function of this protein?
Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia.  In vitro L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position.  In vivo L-, D- and a mixure of DL-DAP allow growth.  DL-DAP is toxic in the absence of this enzyme, it may inhibit enzymes involved in the synthesis of pyruvate and aspartate, as well as amino acids derived from them.
What are the official names of this protein?
Diaminopropionate ammonia-lyase, DAPAL, 2,3-diaminopropionate ammonia-lyase, Alpha,beta-diaminopropionate ammonia-lyase, Diaminopropionatase.
What is the protein family that this protein belongs to?
Belongs to the diaminopropionate ammonia-lyase family.
Protein: LEPA_LIMRD
Sequence: MNLEEMKERQKHIRNFSIVAHIDHGKSTLADRILEMTDSISKREMKNQILDDMPLERERGITIKLNAVALTYHAKDGEDYIFHLIDTPGHVDFSYEVSRSLAACEGAVLVVDATQGVEAQTLANVFLALDNDLEILPVINKIDLPSADPEGTKKQIEDEIGLDPDEAVDISAKTGMGVDEVLEKIVKDVPAPTGDLTAPLKALIFDSKYDDYRGVVLSVRVVEGTVKKGDRIKLMNGGTEYEVAEVGINSPKPLARDVLMAGDVGYITAAIKDIKDTRVGDTVTSADNPTDKPLEGYRQMTPMVYAGLYPTDNAKFNDLRDALEKLQLNDAALTFEPESSQALGFGFRCGFLGLLHMDVIQERLEREFNLDLITTAPSVTYHVELADGTTKEVENPAEMPDASSIKAIKEPYVRASIMVPNDYVGPVMELCQRKRGDFDTMEYLSDTRVNVIYHIPLSEIIFDFFDKLKSSTRGYASLDYEIDGYRPSNLVKIDILLNGDKVDALSFIAHRDFAAERGREITAKLKKIIPRQNFEIPIQAAIGSKIIARTNIKAYRKDVTARIHTGDPDRRAKLLDKQKRGKKRMKAVGKVDIPQAAFMAVLKTDEQLDEK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: KCY_SHEWM
Sequence: MSERAPVVTIDGPSGAGKGTISQLLAERLGWKLLDSGAIYRVLALAAIHHNVELDNEDSLTLLAAHLDVQFITGNGSKGIKVVLEGEDVSNDIRSQECSNAASKVAAFPRVREALLRRQRAFSEAPGLIADGRDMGTVVFSKAPVKLYLTASAEERAQRRYNQLQDKGFDVNIDQLLTEIKERDDRDMNRSVAPLVPAEDALVIDTSQIGIEEVLNIALAHIETNLSGVS
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_SHEAM
Sequence: MSNRRETRKAAQDFIDNLKPLRRPNSEKIFIEGSRPDIQVGMRQIHQTDTRIVNTRGEETFEANPPIKVYDCAGPYSDPNADINVRRGLPKLREGWILARSDTEELNSASSNFTQQRLADDGLDHLRFDVLPKPRRAKAGKRVTQLHYARQGIITPEMEYIAIRENMARDEVTDEQLNRKKPGEAFGALVSKPITPEFVRDEVARGRAIIPANINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIVRNSPVPIGTVPIYQALEKVNGIAEDLNWEVFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTAKRVTGIVSRGGSIMAKWCLSHHQENFLYTHFRDICELCAAYDVSLSLGDGMRPGSIADANDEAQFAELETLGELVKIAWEYDVQTIIEGPGHIPMQLIKENMDKQLEHCAEAPFYTLGPQTTDIAPGYDHFTSGIGAAMIAWYGCAMLCYVTPKEHLGLPNKEDVKQGLIAYKIAAHAADVAKGHPGAQIRDNALSKARFEFRWEDQYNLGLDPDTARAYHDETLPQESAKVAHFCSMCGPKFCSMKITQDVRDYAASLENAARSEADSVQTLEVGAAESYSKAESYARAGMDKMSATFKQTGSALYSETHVEAALSTEKEPV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: EFTUB_NICSY
Sequence: MASISAASATATASTKLAYPYSPSSSSSSSNTAAVFPSNSSKLILSSSFTPTPSTLFLHSPTTTPSTTHPRRFTVRAARGKFERKKPHVNIGTIGHVDHGKTTLTAALTMALASMGNSAPKKYDEIDAAPEERARGITINTATVEYETENRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSGADGPMPQTKEHILLAKQVGVPNMVVFLNKQDQVDDEELLELVELEVRELLSSYEFPGDEIPIISGSALLALEALMANPSIKRGENQWVDKIYQLMDNVDEYIPIPQRQTELPFLMAIEDVFSITGRGTVATGRVERGTVKVGEIVDIVGLKDTRNTTVTGVEMFQKILDEAMAGDNVGLLLRGIQKIDIQRGMVLAKPGTITPHTKFEALVYVLKKEEGGRHSPFFAGYRPQFYMRTTDVTGKVTVIMSDKGEESKMVMPGDRVNMVVELIMPVACEQGMRFAIREGGKTVGAGVIQKILE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor TuB, chloroplastic, EF-TuB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BHA15_RAT
Sequence: MKTKNRPPRRRTPMQDAEATPGEQTPDRSQSGSGASEVTKGLRSRTARASGTRAEVSRRRQGSSSRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQQQQQQQVAGAVLGVTEDQPQGHLQRYSTQIHSFREGS
What is the function of this protein?
Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated.  Repression may occur through muscle-specific E-box occupancy by homodimers.  May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain.  Serves as a key regulator of acinar cell function, stability, and identity.  Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport.  May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages.  Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
What are the official names of this protein?
Class A basic helix-loop-helix protein 15, bHLHa15, Class B basic helix-loop-helix protein 8, bHLHb8, Muscle, intestine and stomach expression 1, MIST-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSP9_PLAFC
Sequence: MMNMKIVLFSLLLFVIRWNIISCNKNDKNQGVDMNVLNNYENLFKFVKCEYCNEHTYVKGKKAPSDPQCADIKEECKELLKEKQYTDSVTYLMDGFKSANNSANNGKKNNAEEMKNLVNFLQSHKKLIKALKKNIESIQNKKHLIYKNKSYNPLLLSCVKKMNMLKENVDYIQKNQNLFKELMNQKATYSFVNTKKKIISLKSQGHKKETSQNQNENNDNQKYQEVNDEDDVNDEEDTNDDEDTNDEEDTNDDEDTNDDEDTNDEEDTNDEEDHENNNATAYELGIVPVNDVLNVNMKNMITGNNFMDVVKNTLAQSGGLGSNDLINFLNQGKEIGENLLNITKMNLGDKNNLESFPLDELNMLKDNLINYEFILDNLKTSVLNKLKDLLLRLLYKAYVSYKKRKAQEKGLPEPTVTNEEYVEELKKGILDMGIKLLFSKVKSLLKKLKNKIFPKKKEDNQAVDTKSMEEPKVKAQPALRGVEPTEDSNIMNSINNVMDEIDFFEKELIENNNTPNVVPPTQSKKKNKNETVSGMDENFDNHPENYFKEEYYYDENDDMEVKVKKIGVTLKKFEPLKNGNVSETIKLIHLGNKDKKHIEAINNDIQIIKQELQAIYNELMNYTNGNKNIQQIFQQNILENDVLNQETEEEMEKQVEAITKQIEAEVDALAPKNKEEEEKEKEKEKEKEEKEKEEKEKEEKEKEKEEKEKEKEEKEEEKKEKEEEQEEEEEEIVPENLTTEESK
What is the function of this protein?
During the asexual blood stage, involved in the sialic acid-independent (SAID) merozoite invasion of host erythrocytes by binding to host SLC4A1/Band 3 protein on the surface of the host erythrocyte.
What are the official names of this protein?
Merozoite surface protein 9, 101 kDa malaria antigen, Acidic basic repeat antigen, p101 protein.
What is the protein family that this protein belongs to?
Belongs to the plasmodium ABRA family.
Protein: TRPF_HALMA
Sequence: MTRVKICGVTDTEDRDAVVTAGADAVGIIHGVPVDTPREVDEGTAETIADGVPPFVTSVLVMMPTTVQEAVRRIDRIEPDAVQVHDGLSPAELGALNNRITQDIVAVVEADAPAIEDYATHADALLVDSVDADGGGGTGETHDWERTRDLVDSLDVPIVLAGGLTPENVTEAVETVEPFAVDVASGVESAGGTKDHDAVGRFVRNAKQAPEGAV
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: PURQ_PYRAB
Sequence: MPRFAVIVFPGTNCDFETVEAIRKAGGEAERVWYKESIREYDGVVLPGGFSYADYLRAGAIAARQRIMEEVREFAEEGRPVLGICNGFQVLTEAGLLPGALRPNKIPRFICKWIYLKVNDTNTAFTQLYEEGEIIRMPIAHAEGNYYVDDPSRIRIVFQYSDENGNLTEEANPNGSVMNIAGVSNEGGNVLGMMPHPERASDAFLGSEDGLKVFRSMVEYAKR
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_ECO7I
Sequence: MLEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSEIILNANAQDVADARANGLSEAMLDRLALTPARLKGIADDVRQVCNLADPVGRVIDGGVLDSGLRLERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAVILRGGKETCRTNAATVAVIQDALKSCGLPAGAVQAIDNPDRALVSEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIYVDESAEIAEALKVIVNAKTQRPSTCNTVETLLVNKNIADSFLPALSKQMAESGVTLHADAAALAQLQTGPAKVVAVKAEEYDDEFLSLDLNVKIVSDLDDAIAHIREHGTQHSDAILTRDMRNAQRFVNEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGIGDYTIRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA_STAAC
Sequence: MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMRTD_BOVIN
Sequence: MDPSEMPAVHHCPSDSATGGETRAPQGMELIPRRAVRRSPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLTQGLMRGAAPPRAPSRVKKGVTQPGVHSGKENIAPQPQIPHHVVPLALTSPGKENSRGPLLLSRPPEALPLPWTPMPPGPWAPGHWLPPGLSMPTPVVCRLLCQEPAIPLHPFPGFDPGTTLRLPTHGPLPTCTGSHPILTAPLSGESQGPSTLPRTCSTLILQPCGTPDPLLLQPQAPGPSRLTWTSASSEWQLQREAAEALVGLKDSSQAPRLTPGPANPAWISLLHPCGPPAAAGGRGFQPVGPSLRPSPAPSVALHIGRLGSISLLS
What is the function of this protein?
May be involved in sexual development.
What are the official names of this protein?
Doublesex- and mab-3-related transcription factor C2.
What is the protein family that this protein belongs to?
Belongs to the DMRT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU2M_SURSU
Sequence: MKPPILFTILLTVISGTMIVLMSSHWLMIWIGFEMNTLAIIPILMKKSNPRAIEASTKYFLTQATASMILMMGITINLMYSGQWTMSKTLCPMASTMMTIALAMKLGLAPFHFWVPEVTQGVHMSSGLILLTWQKIAPLLVLYQISPTIDPNLLLPMAMMSVLIGGWGGLNQTQLRKILAYSSIAHMGWMATITLYNPTMMLLNLTIYIIMTLTTFMLFMHNSTTTTLSLSQTWNKTPLVTSLILMLMLSLGGLPPLSGFIPKWMIIQELTKNEMIIMPTLLAITALLNLYFYMRLTYTTTLTMFPSTNNMKMKWKFDNTKKMILLPPLTVISTMLLPITPLLSILD
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TGL_BACC4
Sequence: MIVIGRSIVHPYITNEYEPFAAEKQQILSIMAGNQEVYSFRTADELSFDLNLRVNIIISALELFQSGFQFRTFQQSFCNPQYWKRTSLGGFELLPNIPPSIAIQDIFKNGKLYGTECATAMIIIFYKALLSLYEEETFNRLFANLLLYTWDYDQDLRLITKNGGDLVPGDLVYFKNPQVNPATIEWQGENTIYLGNFFFYGHGVGVKTKEEIIYSLNERRVPYAFISAFLTDTITRIDSRIMSQYASSSTPQTSISFIPIRDDAIVATVGHTTTIY
What is the function of this protein?
Probably plays a role in the assembly of the spore coat proteins by catalyzing epsilon-(gamma-glutamyl)lysine cross-links.
What are the official names of this protein?
Protein-glutamine gamma-glutamyltransferase, Transglutaminase, TGase.
What is the protein family that this protein belongs to?
Belongs to the bacillus TGase family.
Protein: UBP10_HUMAN
Sequence: MALHSPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKPTAERTAYLLYYRRVDLL
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR.  Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53.  Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response.  Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes.  In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13.  Does not deubiquitinate MDM2.  Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.  Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).  Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 10, Deubiquitinating enzyme 10, Ubiquitin thioesterase 10, Ubiquitin-specific-processing protease 10.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP10 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447).
Protein: SPC24_ASPOR
Sequence: MLLDENPGTLIHHTIGNFNIQPDKQAVTRINDSLSTLQQSRELRMREAESSLRKLSRHLHSLNAQHEEAVAAHDSSKHAADMVELDTKKFRIAKAATELEIESERLESELEMLKERLADLEAQGLEGDEATRRERELDDATILRLKIYRSLGVDIEADDAGNFNKAVIRNSRKGDVHVVNIDPKFSRFFYSNYFWSTMQG
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Probable kinetochore protein spc24.
What is the protein family that this protein belongs to?
Belongs to the SPC24 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Associated with kinetochores.
Protein: COAD_FRATM
Sequence: MNKIAIYPGTFDPITNGHVDLVERALNIFDEIVVAVSTAYGKNTLFDIRIREQMIKEVFKDNQRVKVVSFQGLLVDTAVKHNACAIVRGLRAVSDFDYEFQMSSVNNKLNSDIQTIFLTPSEKFSCISSTLVRAVAIHNYKRVDEFVPECVFREIKLKYSKE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_THEPX
Sequence: MQSVSIEAIKRDTGKNAARRLKNQGYIPAILYGKGMAESIPLAVEYNKLQRLLQKHGRNVLLNVIVDGSTHNAVIKEIQEDTLKGKIIHVDFQRVSMYEEIEATVPLKFEGTGLIESRGGIVQHQLWELTVESLPDKIPQEIVVDLSNLEIGDTLFVKDIQVPEGVKVVDDPDEIVVSVLAPRESEEEAEEEATETAKESE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: YM119_YEAST
Sequence: MRLLVQKVILIYLARYAKSMKEIQYYGPADVLPFARIAEFLWVYVGSALAYVVGVKFMGTVRFILFQIVNNSLRTFAWYLKEVFRLGALALITIARAFCVAHINIIIINQVFFLWEMFELKLYL
What are the official names of this protein?
Putative uncharacterized membrane protein YMR119W-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNMG_PARPJ
Sequence: MLFPTEFDVIVVGGGHAGTEAALASARMGNTTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAAATDEGGIQFRILNSSKGPAVRATRAQADRLLYKQAIRHRLENQPNLWLFQQAVDDLMVEGDRVVGAVTQVGIRFRARAVVLTAGTFLDGKIHVGLNNYTGGRAGDPAAVSLSARLKELKLPQGRLKTGTPPRIDGRTIDFSQLEEQPGDLDPVPVFSFLGRVEQHPRQVPCWVTHTNERTHDIIRGGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFASKESHQIFLEPEGLTTNEFYPNGISTSLPFDVQLELVRSMRGLEHAHILRPGYAIEYDYFDPRGLKASLETKVINGLFFAGQINGTTGYEEAAAQGLLAGINAGLFVQGKEAWCPRRDQAYLGVLVDDLVTRGVSEPYRMFTSRAEYRLSLREDNADMRLTEIGRELGVVDDIRWDAFSRKRDAVSRETERLRTTWVNPKTLPADEATPLLGKPIDHEYSLADLLRRPGVSYDGVCGLRAGACAAPEALAEDDVLLAQIKEQIEIGIKYQGYIDRQAGEIERNEAHESTRLPEGVDYAEVRGLSFEARQKLTQFRPETIGQASRISGITPAAISLLMVHLKRGLGRRPTKPAEPGADNKPVTQ
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP5_CANGA
Sequence: MTSIDKQKERLEKLARWKQKKSESKAVLNTQNVNTNSQSSNQNNVSDIENKLEKVKAWKKRKLEVKSDQQTPPATQSEINHTSSVRLEENIQGIKRKKRQKRVSNVFDEVKPINSTPTNDAQLSESDILEKVDLNTEDPLDSFFGNIETTEEFHFEVIDNKVNNDELLDEDNSKFDALQKEQKKLAKAKKNKNKKLLTPVNFRNIDLDPISKCLYNEPEEIKSYTEDEIADLRLDLDNIKIEGKDCPRPVTKWSQLGIPYDIIRFIKDVFSYKSLTPIQTQTIPAIMSGRDVIGISKTGSGKTISYLLPMIRHVKAQKKLRNGETGPIAVIFAPTRELAVQINEEVQKLISDLDISSICCTGGSDLKKQIDKLKTGVEIAIATPGRFIDLLSLNGGNLVSTLRISFVVMDEADRLFDFGFEPQIASVLRTVRPDRQCVLFSATFPSKVSNFASRFLDSPLQITVNAEGMVNERINQKFTICSDESDKFKELLSLLKVFNSETVDEKTIIFVSSQQICDIIEKRLTDYSEKLYSIHAGRPYNERRQNLELFKKTSNSILLCTEVMSRGLNVPEVSRVILYNSAKTFAQYVHSTGRTARGTREGTSISLLLPNELSSAYILNKAMRDKDFSECPVKEVKNLKQMAQKFEDGLKSGKYKLSTGLGGKGLENMDNSKETSNNDLDEQLKHQDNISISQEADLPDDFKFDTSVETVTNADGTIATVCKFVVNDLPQLVRWEMTKNTSISNMIRETGCSITLRGRYYPPSNVTNDNNTEPKLYLLIEATDDKAVRHCVDLLKDNARVGFMKATSESLRNTKY
What is the function of this protein?
ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing.  Catalyzes an ATP-dependent conformational change of U2 snRNP.  Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
What are the official names of this protein?
Pre-mRNA-processing ATP-dependent RNA helicase PRP5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFP_HALHL
Sequence: MATYSTNEFKGGLKIMLDGDPFTIVENEFVKPGKGQAFNRVKLRNLKTNRVVEKTFKSGESVEAADVMETELQYLYNDGEFWYFMDPTSFEQKAAPSSAVGDAANWIKEQDTCTVILWNDTPLQVEAPNFVDLKVIETDPGVRGDTSSGGTKPAKLETGATVRVPLFIEEGEVLRVDTRKAEYVSRAKD
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIE_PHOLL
Sequence: MSIQAIESVLQLMQAQALQAASIAKPLPLQSGFASQLMAAVGKINQTRLNATKRAQDFTLGVPGVELNDVMVEMQKSSIALQIGVQAKNKLTASYQEIMNMQV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.