PharMolix/UniProtQA huggingface dataset:
Protein: ENO_CLOBK
Sequence: MKNYIEIVDVYARQILDSRCNPTVEVEVELEDGTVGVAAVPSGASTGAFEAVELRDGDKSKYLGKGVLKAVDNVNTIIADELVGMNVLDQVAIDKTMIELDGTDNKAKLGANAMLGVSLACAKAAANSLGMSLYQYIGGVNAKVLPVPMMNIINGGKHADNNVDLQEFMIMPAGAPSFSEALRMCSEVYHALKSTLKSQGYDTGVGDEGGFAPNLKSNEEAIVVIIEAIKEAGYTPGKDIFIALDPASSEIFEDGKYNLAGEGRVLTPEEMANYYVELAEKYPIISIEDGMAEEDWDGWKILTEKIGNKVQLVGDDLFVTNTERLSKGIKLGVANSILIKLNQIGTLTETLNAIEMAERAGYTAVVSHRSGETEDTTIADLVVAVNAGQIKTGAPARSERVAKYNQLLRIEEELNDMGEYRGLKAFYNINK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: Y6057_MYCVP
Sequence: MAQPEDPEDFVAPAAYRVRAGTMLLANTDLLEPTFRRSVIYVVEHNDGGTLGVVLNRPSETAVYNVLPQWAKLATKPKTMFIGGPVKRDAALCLATLRVGIDPAGVDGLRHVQGRVVMVDLDADPDSIAPMVEGVRIFAGYSGWTIGQLEGEIERDDWIVLSALPSDVLVEPRVDLWARILRRQPMPLSLLATHPIDLSRN
What are the official names of this protein?
UPF0301 protein Mvan_6057.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: GCH1_FLAJ1
Sequence: MINNEDFLDEIGDSHFSSNAKNPLREDAFDITDEEKIEKIKKDVENILQTLGMDLTDDSIKGTPNRVAKMFVKEIFGGLNPAKQPKASTFDNNYKYGEMLVEKNITVYSTCEHHLLPIIGRAHVAYISSGRVIGLSKMNRIVEYYAKRPQVQERLTMQIVQELQKALGTEDVACVIDAKHLCVNSRGIKDIESSTVTSEFGGKFKDPQTKREFLDYIKLDTQF
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: MIAB_PSE14
Sequence: MAKKLYIETHGCQMNEYDSSRMVDLLGEHQALEVTARAEDADVILLNTCSIRERAQDRVYSQLGRWRELKLANPEMVIAVGGCVASQEGAAIRDRAPYVDVVFGPQTLHRLPEMIDAARITRLPQVDVSFPEIEKFDHLPEPRVDGPSAYVSVMEGCSKYCTFCVVPYTRGEEVSRPFDDVLSEVIHLAENGVREVTLLGQNVNGYRGTTHDGRVADLADLIRVVAAVDGIDRIRYTTSHPLEFSDSLIQAHAEVPELVKHLHLPVQSGSDRILAAMKRNHTTLEYKSRLRKLRAAVPGISISSDFIVGFPGETEKDFDNTMKLIEDVGFDFSFSFVYSPRPGTPAADLKDDTPEALKKERLAALQHRLNQQGFEISRQMVGSIQRILVTDYSKKDPGELQGRTENNRIVNFRCNNPKLIGQFADVHIDDAQPHSLRGSLLQ
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APC10_SCHPO
Sequence: MAQIRQEALKKQKSETQKSTEGFVDIGNLAQWTCSSEKSGFPIRLVRDDNIDTYWQSDGSQPHTIHIKFVKRVSIKYVSMYLQYTLDESYTPSTLRISAGTGFQDLEIVTTVQVEEPTGWVHVPVGDFGRNGLLDVHLIQIKILANHQSGKDSHVRLIKIYAPEIEQPAIAVDEIPYTSLQFISRNQLR
What is the function of this protein?
Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  Acts as a positive regulator of the anaphase promoting complex (APC)-cyclosome.  Involved in G1 cell cycle arrest in response to nitrogen starvation.  Required for ubiquitination and degradation of the mitotic B-type cyclin, cdc13.
What are the official names of this protein?
Anaphase-promoting complex subunit 10, 20S cyclosome/APC complex protein apc10.
What is the protein family that this protein belongs to?
Belongs to the APC10 family.
Protein: RL7_ACIC1
Sequence: MAKLSTDELIEAFKELSLLELSEFVKRFEETFGVTAAAPVAVAAAPAAGAGAAPAEEVEEQAEFDVILEDAGAQKIQVIKAVRELTSLGLKEAKDLVDGAPKPVLEKVNKETADKAKAALEGAGAKVTVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: TBB_UNCNE
Sequence: MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERTNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYEICMRTLKLSNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMYDPKNMMAASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSAYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVHEYQQYQDASISEGEEDYEEEPQVENEE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: P2RX6_RAT
Sequence: MQLQPAGTGSMASAVAAALVSWGFLDYKTEKYVMTRNCWVGISQRLLQLGVVVYVIGWALLAKKGYQEWDMDPQISVITKLKGVSVTQVKELEKRLWDVADFVRPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWADEDCPEGEMGTYSHGIKTGQCVAFNGTHRTCEIWSWCPVESSAVPRKPLLAQAKNFTLFIKNTVTFNKFNFSRTNALDTWDNTYFKYCLYDSLSSPYCPVFRIGDLVAMTGGDFEDLALLGGAVGINIHWDCNLDTKGSDCSPQYSFQLQERGYNFRTANYWWAASGVESRSLLKLYGIRFDILVTGQAGKFALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKYEEARAPKATTNSA
What is the function of this protein?
Receptor for ATP that acts as a ligand-gated ion channel.
What are the official names of this protein?
P2X purinoceptor 6, P2X6, ATP receptor, P2XM, Purinergic receptor, Purinergic receptor P2X-like 1.
What is the protein family that this protein belongs to?
Belongs to the P2X receptor family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NSS_BUNGE
Sequence: MSLITSGVLLTQSQDTLTFSVTTCQGLRLTKFASSTLKDARLKIVSQKEVNGKLRLTLGAGRYLYSIRISLETGTMQCLTTVLPSTVSVDTLPGTYLESTLQRQNQKSS
What is the function of this protein?
Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II.  Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented.  Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response.  NSs also seems to be involved in the nuclear relocalization of host PABP1 (By similarity).
What are the official names of this protein?
Non-structural protein NS-S.
What is the protein family that this protein belongs to?
Belongs to the orthobunyavirus NS-S protein family.
Protein: DHYS_SULIY
Sequence: MINREDLLKNPVEDIALSDLEKYSDIVNVFDKIYGFSSEGIVRGSKILKEMIKDADLRFLSFTANLVSTGLRGLFADLVKRGYFNIIVTTGGTIDHDLARSFGGVYYKGSFDIDDAMLKDLEIHRLGNVLVPFESYGKVIEEIVRKFLPEIAKDKKEIPAYELLWEFGKRISDSNSILRAAYEKKVPVIVPGIVDGSFGTNLFIQSQFLNFKINLFEDMRLIKDLVFSCKKSGALIIGGGISKHHTIWWNQFKDGLDYAVYVTTAQEYDGSLSGAKPREAISWNKIRPNAKHATIYGDATIIVPILAASLLS
What is the function of this protein?
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
What are the official names of this protein?
Probable deoxyhypusine synthase, DHS.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: SYL_PYRAR
Sequence: MSELARFFIELGEKWQKRWAEARVYEPAPTLGVPKFFITAAYPYPNGAIHIGHGRTYLIADVLARFHRHLGRAVLFPMAFHYTGTPILTIAEAIAAGDETVVEEYMAIYGVPEEEMRKMGDPLYLARYFHEQSKRAMQKFGLSIDWTREFTTIDPEYQRFIQWQFEKLRKKGLIVRGRHPVGWCPRHSMPVGAHDTKDDKEPDIGEWTLIYFADRDGLIFPAATLRPETVLGVTNMWINPEGEYVVAEYDGRKMVLSRDAAYRLSFQGSVKVLREAKGREFVGREVQNPVTGEWVPIYGAKFVDPKVGTGVVMSVPAHAPYDYAALRDIGAIRLIPLIKVEGYGEYPAKDVVERMEIKSQTDPALEEATKEVYSAEYARGVMREDVVELVGRHLPEPARSMVMAVFKMYFAGRPVREAREFISKWLAEAGLGGVMYDIMNKPVYCRCGTEIVVKVLEDQWFINYGEPRWKELAKKLVEEMTIVPPEAKAQFFATIDWLDKRACARTRGLGTPLPWSHGWVIESLSDSTIYMAYYAVIKGIRRHNLRPEQLTEEFWDYVFLGVGTPEEVSAKTGIPAEALRAIREEFEFWYPLDSRNSGKDLIPNHLTFFIFNHVAIFPREKWPRQIVANGWVLREGEKMSKSKRNVLPLDKAVEMYGPDPLRATLAISAEVEQDLDFRHAEAVRNAQQLMSIYTLAQRLAQSAEDREPTWLDRWLLSEVALALERVRDAYEKVRVRQAAVELLYNIKNIFDSYMTAVERPSRLAVEVAKAWAVALEPIAPHLAEEVWSLLGGEGFVTSAKWPQLKPDPAALLARRYVDMVVEDVKKIPAYGEGVRRVVLYINPNFTWVKAALNNDVKSAIAAGTPPQLAKRLVELVRTLGDEVRSLIAAVENFDEREALLSYKNYVEKALGAPVEVYTAEDPAAPDLGGKKKAALPLKPGIFIER
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_SHEB5
Sequence: MKASELREKSVEELNAELLGLLREQFNLRMQHATGQLTQTNQLKLVRRNIARVKTIITSKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: THII_THET8
Sequence: METLLLVQLFHELALKGKNRPFFLKRAKAHVRRALKGLGVALEGEWPMALLFRLPEEAWPEAKARLQDTLGVERFARVHRTPPDLEALKAALEKALEGQAFGSFRITAKRSDKAFPLTSPEIERALGAFVKGKTGAPVRLKGAEREFVVRVLPGAALLEVERHPGPGGLPPGVSGRVVALLSGGIDSPVAAYRLMRRGAEVVLVHFHPFPLLSGASREKAKALAERLARFQHRLRLHLVPFSEVQRHIIVEAPTAYRVVLYRRYMLRIAEAIAREEGALALCTGDSLGQVASQTLENLHAVNQAATLPVFRPLIGWDKEEIVAEAQRIGTYATSILPDEECCTLFAPKHPVTRARLEVVLETEARLPTEELLALALKEREVLTYTWPGKPLPEEPEGAFIMEHGPA
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYNS_BURO1
Sequence: MIQSQHSQTARHALAETVVLAKARKNLSFAQLTEGTGLSEAFVTAALLGQHALPADAARVVADKLGLDDDAVLLLQMIPLRGSIDDRVPTDPTIYRFYEMLQVYGTTLKALVHEKFGDGIISAINFRLDVKKVDDPEGGSRAVITLDGKYLPTKPF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: PDXT_IGNH4
Sequence: MKVGVLALQGGVVEHIYMIREAAKRLGKEVEVVEVRKPEHLNSLRAIVLPGGESTAMYKLGKRTGLDKRLKEALLEGLPALGTCAGAALLAREIEDKQSGKRYEPLLGVADFKVVRNFFGRQRESFEANLNIKGIGTFRGVFIRAPVMVPLSPAVEVLGEFKGNAVMVKQGNIIATSFHPELTSDTRIHEMLLSEAS
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: CDA1_BOMMO
Sequence: MARYARVATLAACLLFACALADGHRWRRQADETAKKDESLEQELCKDKDAGEWFRLVAGEGDNCRDVIQCTASGIQAIRCPAGLFFDIEKQTCDWKDAVKNCKLKNKERKIKPLLYTEEPLCQDGFLACGDSTCIERGLFCNGEKDCGDGSDENSCDIDNDPNRAPPCDSSQCVLPDCFCSEDGTVIPGDLPARDVPQMITITFDDAINNNNIELYKEIFNGKRKNPNGCDIKATYFVSHKYTNYSAVQETHRKGHEIAVHSITHNDDERFWSNATVDDWGKEMAGMRVIIEKFSNITDNSVVGVRAPYLRVGGNNQFTMMEEQAFLYDSTITAPLSNPRLCPYTMYFRMPHRCHGNLQSCPTRSHAVWEMVMNELDRREDPSNDEYLPGCAMVDSCSNILTGDQFYNFLNHNFDRHYEQNRAPLGLYFHAAWLKNNPEFLEAFLYWIDEILQSHNDVYFVTMTQVIQWVQNPRTVTEAKNFEPWREKCSVEGNPACWVPHSCKLTSKEVPGETINLQTCLRCPVNYPWLNDPTGDGHY
What is the function of this protein?
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.
What are the official names of this protein?
Chitin deacetylase 1, BmCDA1.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate esterase 4 (CE4) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNP2_METTH
Sequence: MKILPPTLRVPRRYIAFEVISERELSREELVSLIWDSCLKLHGECETSNFRLWLMKLWRFDFPDAVRVRGILQCQRGYERRVMMALTCAHHHSGVRVAIHILGLSGTIRSATQKFIKPSKKDKY
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 2, RNase P component 2, Pop5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB1_BACLD
Sequence: MKKQRIVIKIGSSSLTNSKGSIDEEKINDHVRAIAALKKEGHEVIFISSGAVAAGFLQLGYPARPVTLKGKQAAAAVGQSLLMQTYIEHFADHDIKPAQILLTRNDFAKRERYRNAYATVMELIERGLVPIINENDSVSVEELTFGDNDMLSALVSGLIHADKLIILTDINGLYDSNPAEHPDARRFDYIPEITDELLGCAASAGSKVGTGGMKSKLLAAKTALSLGVNVFIGAGEGDDKLIQILKGNGDGTYIGQSDLSSVNNHRQWIAFHSPVSGKITVDEGAELAITENGGSLLPAGVTAISGDFPKGAVVEVYGPNGLAGKGQTLYSAAELEEVKGKRSDEFHHEEGIEVIHRNDWVSIKE
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase 1, Gamma-glutamyl kinase 1, GK 1.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM6_STRM5
Sequence: MNEFERVRAYLTDLQDRICAAIEAADGQARFQEDLWQRAEGGGGRTRVLRDGAVFEQAGIGFSDVAGSRLPPSASANRPELAGASWRATGVSLVFHPLNPYVPTTHANVRFFQAQRDGEVVASWFGGGFDLTPFYPFDEDVQHWHRVARDLCAPFGDERYAAHKRWCDEYFFLRHRNETRGVGGLFFDDLHGDFERDFDYLRAVGDGFLDAYLPIVQQRKDTAYGEREREFQLYRRGRYVEFNLVYDRGTLFGLQSGGRSESILMSLPPRVRWEYGFNPEAGSAEARLADYLVPRDWL
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDKL3_MOUSE
Sequence: MEMYETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTARKKYPKLNGLLADIVHACLQIDPAERTSSTDLLRHDYFTRDGFIEKFIPELRAKLLQEAKVNSFIKPKENFKENEPVRDEKKSVFTNTLLYGNPSLYGKEVDRDKRAKELKVRVIKAKGGKGDVPDQKKPEYEGDHRQQGTADDTQPSSLDKKPSVLELTNPLNPSENSDGVKEDPHAGGCMIMPPINLTSSNLLAANLSSNLSHPNSRLTERTKKRRTSSQTIGQTLSNSRQEDTGPTQVQTEKGAFNERTGQNDQISSGNKRKLNFPKCDRKEFHFPELPFTVQAKEMKGMEVKQIKVLKRESKKTDSSKIPTLLSMDPNQEKQEGGDGDCEGKNLKRNRFFFSR
What are the official names of this protein?
Cyclin-dependent kinase-like 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPPA_SACS2
Sequence: MRIIPRTMSTQHPDNAKVPEWAKSEVIEGEDEVKEAFLAYSMYGVHEVMWDAEGKDVDTHVVRKLLSNYPDYFREHILGKDLFLTYRLPNPKVEGADRKVFAETMESIPITYDLAEKFYGNGITIPVFEVILPMTTSSLEIISVARYYEKAVANEDELELYDGVKVKDLVGEIYPKVIEVIPLVEDRDSLQNINNIVEGYYKVIKPKYMRVFLARSDPAMNYGMITAVLSVKIALSELYKLSESLNFEIYPIIGVGSLPFRGHLSPENYEKVLEEYKGVYTYTIQSAFKYDYDYDKVKSAISSINNSRISPARILEKYEEDVLRKITILYTERYQPIIESLANAINDVSVLLPRRRARKLHIGLFGYSRSAGKVSLPRAISFVGSLYSIGIPPELIGISSLSNLDEKEWDIFKQNYVNFKHDLQTAARFLNWESFKLIKDIWKISEDTIAKIKEDIDYAESVIGIKLGGIDYDSRKHILMSSLFLLSFKEKILQESKKYLYEMALIRRSLG
What is the function of this protein?
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 2 family.
Protein: ATPB_PARL1
Sequence: MSNAVGKIAQVIGAVVDVTFTDNLPAILNALETTNGGNRLVLEVAQHLGENTVRTIAMDTTEGLTRGQEVRDTGNAITVPVGEGTLGRIINVIGEPVDEAGPVKHEARREIHQEAPSFVEQSTEAQMLVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIQELINNIAKAHGGYSVFAGVGERTREGNDLYHEMIESGVNKDPNENNGDTTGSKCALVFGQMNEPPGARARVALTGLTVAEHFRDKGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGALQERITTTTKGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLNRAISEKGIYPAVDPLDSTSRILEPRVVGQEHYDTARQVQEILQRYKSLQDIIAILGMDELSEEDKLVVARARKIERFLSQPFFVAEVFTGTPGVLVDIKDTIKGFKGLCNGDYDHLPEAAFYMVGTIEDAVAKAERLAKEAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ENV_SIVVG
Sequence: MKLTLLIGILLIGIGVVLNTRQQWVTVFYGVPVWKNSSVQAFCMTPTTRLWATTNSIPDDHDYTEVPLNITEPFEAWADRNPLVAQAGSNIHLLFEQTLKPCVKLSPLCIKMSCVELNSSEPTTTPKSTTASTTNITASTTTLPCVQNKTSTVLESCNETIIEKELNEEPASNCTFAMAGYVRDQKKKYSVVWNDAEIMCKKGNNSNRECYMIHCNDSVIKEACDKTYWDELRLRYCAPAGFALLKCNDYDYAGFKTNCSNVSVVHCTNLINTTVTTGLLLNGSYSENRTQIWQKHRVSNDSVLVLFNKHYNLTVTCKRPGNKTVLPVTIMAGLVFHSQRYNTRLRQAWCHFQGNWRGAWKEVKNEIVKLPKDRYQGTNDTEEIYLQRLFGDPEAANLWFNCQGEFFYCKMDWFLNYLNNRTVDPDHNPCNGTKGKGKAPGPCAQRTYVACHIRSVINDWYTLSRKTYAPPREGHLQCTSTVTGMSVELNYNSKNRTNVTLSPQIETIWAAELGRYKLVEITPIGFAPTEVRRYTGGHDRTKRVPFVLGFLGFLGAAGTAMGAAATALTVQSQHLLAGILQQQKNLLAAVEAQQQMLKLTIWGVKNLNARVTALEKYLEDQARLNAWGCAWKQVCHTTVPWQWNNRTPDWNNMTWLEWERQISYLEGNITTQLEEARAQEEKNLDAYQKLSSWSDFWSWFDFSKWLNILKIGFLDVLGIIGLRLLYTVYSCIARVRQGYSPLSPQIHIHPWKGQPDNAEGPGEGGDKRKNSSEPWQKESGTAEWKSNWCKRLTNWCSISSIWLYNSCLTLLVHLRSAFQYIQYGLGELKAAAQEAVVALARLAQNAGYQIWLACRSAYRAIINSPRRVRQGLEGILN
What is the function of this protein?
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers.  Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells.  Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells.  This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: TM253_HUMAN
Sequence: MEDRAGEQEQERHSLRLEKLQHWARHRQSGHLLVLAVSQLWLAVVVVPLAVSVACLNSDCHMATALPLGPGASGLLTGTVTLELRRAPRLWKVRAMMIFNTFNLILGFIVVVVEVMKTALGPAPTASSQHAGLLVLELSAEAFTLGGVLVSVHALFLLSQRKPGCCRSQSLHYQELQEGFSELEEVPGLENGPTVASTGANERVGQREQTRAALLPP
What are the official names of this protein?
Transmembrane protein 253.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: XPTA_EMENI
Sequence: MLKHSSAATKENDSPKLKVLDIVSKLEPSLDHSHTHWWKLTSPQLALMLEAADYSIEKQFETLLFHYHWVVPYLGPKPDADGNFKWRSLVSDVGIPLEYSWKWDTATSGPDVRLTIEPINELSGTRVDPLNQAPSLELLHRLAEILPRLDVSWASHFLSTFYDHDKLKYIKESESETGMPLRSTMLVCFEFGRNGITTKTYMSPRKLGQQGFAPLSDYHSAIAALGPSCALDAVTEFLNNSPEGPHLSPFMLAVDNIIPCSSRLKLYFATPRTSYNSIREVLTLGGRLSTVTLESKLRAIHELVKAIMPFPPDLPDDADIPFPEQVLSPTVQDLAESSDMANQRPAFVAGYQYYFDIAPGASLPDIKFYIPIRKAQMNDQAVATGLTNWMRAQGRGAFCNAYTRVLEGLAGGRDLSKCHGLHTHICVMLKGNGEFDVTSYLAPGCK
What is the function of this protein?
Dehydrogenase involved in the conversion of monodictyphenone to the prenyl xanthones such as emericellin, shamixanthone and epishamixanthone (PubMed:21351751, PubMed:22730213).  Monodictyphenone is first converted to variecoxanthone A via a paeciloxanthone intermediate by the consecutive actions of the FAD-dependent monooxygenase mdpD and the xanthone prenyltransferase xptB (PubMed:21351751).  XptB catalyzes regular O-prenylation at the hydroxy group of C-7 of the xanthone ring (PubMed:23150454).  Variecoxanthone A is further prenylated to emericellin by xptA before being reduced to shamixanthone and epishamixanthone by the dehydrogenase xptC (PubMed:21351751).
What are the official names of this protein?
Xanthone prenyltransferase A.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.