PharMolix/UniProtQA huggingface dataset:
Protein: JMJ28_ARATH
Sequence: MSENEIVPDEFRCNRSDGKQWRCKRRALEGKKMCESHHSQQSLKRSKQKVAESSKLVRSRRGGGDEVASSEIEPNESRIRSKRLGKSKRKRVMGEAEAMDEAVKKMKLKRGDLQLDLIRMVLKREVEKRKRLPNSNNKKKSNGGFSEFVGEELTRVLPNGIMAISPPSPTTSNVSSPCDVKVGEEPISMIKRRFRSKNIEPLPIGKMQVVPFKGDLVNGRKEKKMRCHWCGTRGFGDLISCLSCEREFFCIDCIEKRNKGSKEEVEKKCPVCRGSCRCKVCSVTNSGVTECKDSQSVRSDIDRVLHLHYAVCMLLPVLKEINAEHKVEVENDAEKKEGNPAEPQIHSSELTSDDRQPCSNGRDFAVVDLQRMCTRSSSVLRLNSDQDQSQESLSRKVGSVKCSNGIKSPKVCKRKEVKGCSNNLFLSLFPLELTSKLEISAEEVVSCYELPEILDKYSGCPFCIGMETQSSSSDSHLKEASKTREDGTGNFLYYPTVLDFHQNNLEHFQTHWSKGHPVIVRSVIKSGSSLNWDPVALFCHYLMNRNNKTGNTTDCMDWFEVEIGVKQFFLGSLRGKAETNTCQERLKLEGWLSSSLFKEQFPNHYAEILNILPISHYMDPKRGLLNIAANLPDTVQPPDFGPCLNISYRSGEEYAQPDSVKKLGFETCDMVDILLYVTETPVSTNQICRIRKLMKNIGRVRSKNPAKGRESRFDKGKKRDRLDDYSSSDSESSQHCLGAKCRGSEFEGEERESCNYSCEEESLSNTYGAQWDVFQKQDVSKLLEYIKNHSLELESMDSSKKKVSHPLLEQSYYLDEYHKARLKEEFDVEPWSFDQCVGEAVILPAGCPYQIRKNKSCVNAVLKFLSPEHVSESIKRVKELNQLPQSVKSKANKIEVKKMAIHKISEAVKEIRELTSSDSTGALRLYN
What is the function of this protein?
May function as histone H3 lysine demethylase and be involved in regulation of gene expression (By similarity).  Regulates flowering time by promoting CONSTANS (CO) and CONSTANS-LIKE genes (e. g.  COL2 and COL5) expression via interaction with FBH transcription factors (FBH1, FBH2, FBH3 and FBH4) at their loci to remove H3K9me2 repressive histone marks (PubMed:33604650).  Modulates also the expression of several develpmental genes such as MYB30, TFS1, AGL6 and RVE2 (PubMed:33604650).
What are the official names of this protein?
Lysine-specific demethylase JMJ28, Jumonji domain-containing protein 28, AtJMJ28, Protein JUMONJI 28, Lysine-specific histone demethylase JMJ28, Protein B160, [histone H3]-trimethyl-L-lysine monodemethylase JMJ28.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SIP21_MAIZE
Sequence: MSPAPSRPRIRPWLVVGDLALAAAWVCAGALVKLLVYGGLGLGGRPEAEAVKVSLSLVYMFLFAWLEAASGGASYNPLTVLAAALASHGGPAVYLFTAFARIPAQVIGAVLGVKLIQVTFPNVGKGARLSVGAHHGALAEGLATFMVVMVSVTLKKKEMKSFFMKTWITSIWKNTIHLLSSDITGGIMNPASAFAWAYARGDHTTFDHLLVYWLAPLQATLLGVWAVTFFTKPKKIKEQKVDENKIKKE
What is the function of this protein?
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
What are the official names of this protein?
Aquaporin SIP2-1, Small basic intrinsic protein 2-1, ZmSIP2-1, ZmSIP2;1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. SIP (TC 1.A.8.10) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RK20_SACHY
Sequence: MTRVPRGYIARRRRTKMRSFASNFRGAHLRLNRMITQQVRRAFVSSHRDRGRQKRDFRRLWITRINAATRVYNVFNSYSKLIHNLSKKELILNRKMLAQVAVLNPNNLYTISNKIRTIN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: XTH1_ARATH
Sequence: MNKMEYLSIFGFVSVLYLIIRVDARAYEVNGIDQSKVGFDDNYVVTWGQNNVLKLNQGKEVQLSLDHSSGSGFESKNHYESGFFQIRIKVPPKDTSGVVTAFYLTSKGNTHDEVDFEFLGNKEGKLAVQTNVFTNGKGNREQKLALWFDPSKDFHTYAILWNPYQIVLYVDNIPVRVFKNTTSQGMNYPSKPMQVVVSLWNGENWATDGGKSKINWSLAPFKANFQGFNNSGCFTNAEKNACGSSAYWWNTGSYSKLSDSEQKAYTNVRQKYMNYDYCSDKVRFHVPPSECKWNN
What is the function of this protein?
May catalyze xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET).  Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
What are the official names of this protein?
Putative xyloglucan endotransglucosylase/hydrolase protein 1, At-XTH1, XTH-1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted, extracellular space, apoplast.
Protein: YCE2_YEAST
Sequence: MEKKKILDAALAPRIISGVPTDGQPLSGGPLSWAWCHTTLKRWALMKTRPYKYPLSTEPPTPPSVPNSASVNHNTTTNTTLSYTRCHSTTYTKPLRERSSRPWTRSATISRLPPRSWTN
What are the official names of this protein?
Putative uncharacterized protein YCL042W.
Protein: ITA4_HUMAN
Sequence: MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD
What is the function of this protein?
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin.  They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin.  They are also receptors for VCAM1.  Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1.  Integrin alpha-4/beta-7 is also a receptor for MADCAM1.  It recognizes the sequence L-D-T in MADCAM1.  On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines.  It may also participate in cytolytic T-cell interactions with target cells.  ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415).  ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
What are the official names of this protein?
Integrin alpha-4, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: LIPA_CLAMS
Sequence: MSAAPEGRRMLRLEVRNAETPIERKPEWIKTKARMGPEYQALQQLVKTEDLHTVCQEAACPNIYECWEDREATFLIGGSQCTRRCDFCQIDTGKPADYDTDEPRRVADSVRRMGLRYATVTGVARDDLPDEGAWLHAETVRRIHADNPGTGVEILATDFSGNPDLLAEVFSSRPEVFAHNVETVPRIFKRIRPAFRYERSLDVITQGRDADLITKSNLILGMGETREEVSEALADLHDAGCDIITVTQYLRPSPRHLPVARWVRPEEFVEIKAEAEAIGFLGVLAGPLVRSSYRAGRLYAQSMSAKGRELPASLAHLADPANGFAQAVG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YI156_YEAST
Sequence: MTLVGKLVHISIDLVLVSTCLAGIKRNTGLTPKLETLDNQTMRNYMKRYLNLGESVYDYSVATCGSSTYFARK
What are the official names of this protein?
Uncharacterized protein YIL156W-B.
What are the subcellular locations of this protein?
Vacuole.
Protein: ATPB_CELLY
Sequence: MSKVTGKVSQIIGPVIDVEFQAGVDLPKIYDSLEIKKADGSILVLEVQSHIGENTVRTISMDSSDGLSRGAEVNATGSAIQMPVGDDVYGRLFNVIGDAIDGLGNLPKSGKDGLPIHREAPKFEDLSTSTEVLFTGIKVIDLIEPYAKGGKIGLFGGAGVGKTVLIQELINNIAKGHGGLSVFAGVGERTREGNDLLREMLESGIIKYGDDFMHSMEEGGWDLSKVDKSVMKDSKATFVFGQMNEPPGARARVALSGLTIAEYFRDGAGEGQGKDVLFFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGAMQERITSTKRGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRKIAELGIYPAVDPLDSTSRILAPEILGKDHYSCAQRVKELLQRYKELQDIIAILGMEELSEEDKMAVGRARRVQRFLSQPFHVAEQFTGLKGVLVDIKDTIKGFNMIMDGELDHLPESAFNLKGTIEEAIEAGEKMLAEA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CAPS2_PFV2
Sequence: MSVEVYRQKIEKGGYSAAYEATRRYEREEIEVLSWSSRWESAWSKFGEAVKALGKIEGAPRALVIAKVQEALAYMSKPLPNMKLAMAAAVQAVRACEQLPGMNRERCLDAVAGALGVAKDWIRREMTGGGGGGGGGGGGGGGAVV
What is the function of this protein?
Self-assembles to form a helical, filamentous nucleocapsid (Probable) (PubMed:32368353).  Together with capsid protein 2, wraps arounds the DNA and maintains it in an A-form (Probable).  Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable).  This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
What are the official names of this protein?
Major capsid protein 2, MCP2, Major capsid protein VP2.
What are the subcellular locations of this protein?
Virion.
Protein: FABI_SYNY3
Sequence: MLDLSGKHAFVTGIANNRSIAWGIAQQLHQAGAEIGVSYLPDEKGRFEKKVRELTEPLHPTLVLPGDVQDDAQVDALFHSVKEKWGKLDILIHCLAFADKSGLTGNYTDIPKEAFSQAMEISTYSLGRLARGAKPLMTNGGSIITLTYFGGVKVIPNYNLMGVAKAGLEMTVRYLAAELGPQNIRVNGISAGPIRTLASSAVGGILDMIHHVEEVAPLKRTVTQTEVGNTAAFLASDLSSGITGQIIYVDSGYEIMGM
What is the function of this protein?
Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).  Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI, ENR, NADH-dependent enoyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.
Protein: HLDE_AERHH
Sequence: MKITLPEFEKARVLVVGDVMLDRYWHGPTGRISPEAPVPVVKVEHIEERPGGAANVALNSAALGAHAVLLGLTGQDEAADALAGQMAGVKVACDFVRLADYPTITKLRVLSRNQQLLRLDFEEAFHDVDSTLLMGKVEQALPHSDVMILSDYGKGALNDVPSMIQRARAAGIPVLVDPKGTDFEKYRGATLLTPNMSEFEAVVGKVKSEEELVAKGLELVKRFELEALLVTRSENGMTLIREGQPELHLPAQAHEVYDVTGAGDTVISTLATSLAAGKSLDEACALANTAAGIVVGKLGTSTVSPVELANALYTEQETGFGVMSEAQLKIAVQAARLRGEKVVMTNGCFDILHAGHVSYLANAGKLGDRLIVAVNTDESVRRLKGPGRPVNPTERRMAVLAALGAVDWVVPFAEDTPQRLIAEVLPDLLVKGGDYKPEEIAGYAEVTANGGEVRVLNFEDGCSTSDIIKTIRERG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: S23A3_MOUSE
Sequence: MSRSPLHPIPLLSEGYQDTPAPLPPLLPPLQNPSSRSWASRVFGPSTWGLSCLLALQHFLVLASLLWASHLLLLHGLPPGGLSYPPAQLLASSFFSCGLSTVLQTWMGSRLPLIQAPSLEFLIPALVLTNQKLPLTTKTPGNASLSLPLCSLTRSCHGLELWNTSLREVSGAVVVSGLLQGTIGLLGVPGRVFPYCGPLVLAPSLVVAGLSAHKEVAQFCSAHWGLALLLILLMVVCSQHLGSCQIPLCSWRPSSTSTHICIPVFRLLSVLAPVACVWFISAFVGTSVIPLQLSEPSDAPWFWLPHPGEWEWPLLTPRALAAGISMALAASTSSLGCYALCGQLLRLSPPPPHACSRGLSLEGLGSVLAGLLGSPLGTASSFPNVGTVSLFQTGSRRVAHLVGLFCMGLGLSPRLAQLFTSIPLPVLGGVLGVTQAVVLSAGFSSFHLADIDSGRNVFIVGFSIFMALLLPRWLREAPVLLNTGWSPLDMFLRSLLAEPIFLAGLLGFLLENTISGTRAERGLGQRLPTSFTAQEIQMLQQSRRKAAQEYGLPLPIKNLCSCIPQPLHCLCPMPEDSGDEGGSSKTGERADLLPNSGESYSTASREGVRSQ
What are the official names of this protein?
Solute carrier family 23 member 3, Na(+)/L-ascorbic acid transporter 3, Sodium-dependent vitamin C transporter 3, Yolk sac permease-like molecule 1, YSPL-1.
What is the protein family that this protein belongs to?
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
Protein: FIXA_SALPA
Sequence: MKIITCYKCVPDEQDIAINNADGTLDFSKADSKISQYDLNAIEAACQLKQQLGDAQVVAMSVGGKALTNAKGRKDVLSRGPDELIVVIDDQFEQALPQHTATALAAAAQKSGFDLLICGDGSSDLYAQQVGLLVGEALNIPAINGVSKILSLTDSTLTVERELEDEVETLSIPLPAVIAVSTDINTPQIPSMKAILGAAKKPVQVWSPADIGLNSVPAYSTQQVAAPKQRERQRVVIEGDGEEQIAAFVENLRKII
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixA.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: DNAK_CUPTR
Sequence: MGKIIGIDLGTTNSCVAILEGNTPKVIENSEGARTTPSIIAYMEDGEILVGAPAKRQAVTNPRNTLYAVKRLIGRKFEEKEVQKDIGLMPYSIVKADNGDAWVSVRDQKLAPPQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAFGLDKNEKGDRKIAVYDLGGGTFDISIIEIADVDGEKQFEVLSTNGDTFLGGEDFDQRIIDYIIGEFKKDQGVDLSKDVLALQRLKEAAEKAKIELSSSQQTEINLPYITADASGPKHLNLKMTRAKLESLVEELITRTIEPCRTAIKDAGVKVSDIDDVILVGGMTRMPKVQEQVKEFFGKEARKDVNPDEAVAVGAAIQGSVLSGDRKDVLLLDVTPLSLGIETLGGVMTKMITKNTTIPTKHAQVFSTADDNQPAVTIKVYQGEREMATGNKLLGEFNLEGIPPAPRGTPQIEVSFDIDANGILHVGAKDKATGKENRITIKANSGLSEDEIQRMVKDAEANAEEDKKARELADARNQADALIHSTRKAVTEYGDKLEAGEKEKIEAAIKELEDAARGGDKTEIDAKVNALSEASQKLGEKVYADMQAKAGEQGAAGAAGAGAQQQAQPQDDNVVDAEFKEVNDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TATA_ALISL
Sequence: MGGISIWQLLIIAVIIVLLFGTKKLRGVGSDLGSAVKGFKKAISEDESAKDAKKDADFVPQNLEKKEAETVEKQKQNDKEQA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SCN1B_RABIT
Sequence: MGRLLAFVVGAALVSSAWGGCVEVDSETEAVYGMTFKILCISCKRRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYQCHVYRLLSFENYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
What is the function of this protein?
Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle.  Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation.  Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
What are the official names of this protein?
Sodium channel subunit beta-1.
What is the protein family that this protein belongs to?
Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection, axon. Note=Detected at nodes of Ranvier on the sciatic nerve.
Protein: ARLY_STRMU
Sequence: MTTKNHKLWGGRFEAGLAQWVEEFGASISFDQKLAEFDLKGSIAHVTMLGEKGIISQEDAATIKAGLEDLLEEYKAGQLKFDVSNEDIHMNMESLLTAKIGPVAGKLHTARSRNDQVATDMHLYLKAKLDEVIEKLANLRTVLVDLADKHVHTIMPGYTHLQHAQPISFGHHLMAYYNMFTRDSERFIFNVKHTDLSPLGAAALAGTTFPIDREMTAQLMGFAEPYSNSLDAVSDRDFILEFLSNASILMMHMSRMCEEVISWCSHEYQFVTLSDTFSTGSSIMPQKKNPDMAELIRGKSGRVYANLFGLLTVMKALPLAYNKDLQEDKEGMFDTAETITVALDILAGMLSSMIVNDKHMAESTQKDFSNATELADYLASKGMPFRQAHEIVGKLILECSKNGHYLQDVPLERYQTISDLIEEDVYETLKSHTAVERRHSLGGTGFEQVKWQIAEAKKAL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_MARN8
Sequence: MDKLLIRGRKPLDGEIRISGAKNAALPILAATLLADEPVTVGNLPHLNDITTMIELLGRMGVELLIDEKMSVEVHANTIKHFHAPYELVKTMRASILVLGPLVAHFGEAEVSLPGGCAIGTRPVNLHIHGLEMMGADIKVENGYIKAKTNGRLKGAHIFLDTVTVTGTENLMMAAALAEGKTILENAAREPEVVDLAECLIAMGADIKGHGTATIEINGVERLHGCHYNVLPDRIETGTYLVAAAATGGRVKVKDTREDILEAVLLKLEEAGAHITTGPDWIELDMKGKRPKAVSLRTAPYPAFPTDMQAQFAAMNAVAEGSGTIVETVFENRFMHLQELIRMGADITLEGNAAIIKGVEHLTGAPVMATDLRASASLVIAGLMADGDTIVDRIYHIDRGYECIEEKLQLLGASIRRLPA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VDR_BOVIN
Sequence: MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCIDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIITTLLEAHHKTYDDTYSDFSQFRPPVRNSEDEGNRPLRSILTPSFSGNSSSSCSDHCTSSPDTMEPTSFSNQDLNEEDSDDPSVTLDLSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTPEDQIVLLKSSAIEVIMLRSNQSFTLDDDMSWTCGSPDYKYQVSDVTRAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALVEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPESSMKLTPLLFEVFGNEIS
What is the function of this protein?
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells.  Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR.  The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity).  Plays a central role in calcium homeostasis (By similarity).  Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity).
What are the official names of this protein?
Vitamin D3 receptor, VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand- independent pathways; ligand-independent nuclear translocation is mediated by IPO4.
Protein: ARGB_PROM2
Sequence: MNDSQRVSILSEALPYIQSFSGRKIVIKYGGSVMENDNLKNAFFRDIALLSTVGVCPIVIHGGGPEINNWLKKLEISPKFENGLRITDQKTMEIVEMVLMGRVNKQIVKGINKTGSLAVGISGLDGNLIQSRELGDGSHGLVGEVTKINPEILDPLISKGYIPIISSIGSTLEGISHNINADFVAGEIAAAINAEKLILLTDTQGILKEKDNKNSLVEKTNLKEARDFIDKKIVTEGMIPKTECCIRALAQGVKAAHIIDGRIEHSLLLEIFTNSGIGTMIVA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYUA_RAT
Sequence: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPSSEAYEMPSEEGYQDYEPEA
What is the function of this protein?
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity).  Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity).  Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity).  Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity).  This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity).  Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
What are the official names of this protein?
Alpha-synuclein.
What is the protein family that this protein belongs to?
Belongs to the synuclein family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Nucleus. Synapse. Secreted. Cell projection, axon. Note=Membrane-bound in dopaminergic neurons (By similarity). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity).
Protein: FABH_RICB8
Sequence: MTCKIIGCGGYLPPKVVSNDELAKFVDTNDEWIRTRTGISQRHIAGDTEYTSHIALKAAEKAIADADISVNEIDLIITCTTTPDNSFPSVATKLQSYLGLNNVPSFDLQAVCAGFVYGVQVANSLISSGKYKTILLIGAEKMTSLLDWEDRATCVLFGDGAGSVILQRSDDNSGIIDSNIFSSGADYEILYTNGGVSMNGSSGKIIMQGQKLFRLAVEKMHQSIEELLRNNNFTVNDIDYFIPHQANVRIINKLAELLNVEDHKVVKTVEKHANCSAASIPLALSTIKASGKIKKGDIILFSAIGAGLTWGSALLRW
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_BLOPB
Sequence: MNMKNKSEKEMTHFGFQNVYKDKKTSLVSNVFHTVASQYDLMNDLMSFGIHRMWKRFTIYRSEVYVGCIVLDLAGGTGDLSIQFSRLVGNTGIVVLADINDSMLHIGQKKLRDLGILNNVIYIQADAEALPFSENTFDCVAVSFGLRNFTNKEQALFSIHRVLKPRGKLLILDFGVPNFKVLHKIYDLYSFHILPKIGKCITQDINSYRYLVESIRMHPDQETLKNMIIRTGFSNVEYFNMTFGIAVLHCAYKC
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.