PharMolix/UniProtQA huggingface dataset:
Protein: CLCB_ECO5E
Sequence: MFRRLLIATVVGILAAFAVAGFRHAMLLLEWLFLNNDSGSLVNAATNLSPWRRLLTPALGGLAAGLLLMGWQKFTQQRPHAPTDYMEALQTDGQFDYAASLVKSLASLLVVTSGSAIGREGAMILLAALAASCFAQRFTPRQEWKLWIACGAAAGMAAAYRAPLAGSLFIAEVLFGTMMLASLGPVIISAVVALLVSNLINHSDALLYSVQLSVTVQARDYALIISTGVLAGLCGPLLLTLMNACHRGFVSLKLAPPWQLALGGLIVGLLSLFTPAVWGNGYSTVQSFLTAPPLLMIIAGIFLCKLCAVLASSGSGAPGGVFTPTLFIGLAIGMLYGRSLGLWFPDGEEITLLLGLTGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVIASVISRTLHRDSIYRQHTAQHS
What is the function of this protein?
Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
Voltage-gated ClC-type chloride channel ClcB.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS12_SALTY
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RPOC_MYCGE
Sequence: MTTTRRNKRNNKLYKNIKAIKLSIASNDTILNWSEGEVTKAETINYKSLKPEPGGLFDEAIFGPVKDYECACGKFKKIKYRGVRCDRCGVWVTESIVRRERMGHIALVSPVAHIWMSKELPSPSKISLVLNISYKEVEQVLYFVNYIVLDTGKIKDDKIMPFKFKEVLDLTGKGSLSTRQKMRRVIGYIFRNLIKSKSSEDYRKGKIFYESLKNSSLPFSLNDAFNYIKKYTGFRVGIGAEAILELLNKIDLNLEFSRLNDALRKAKKDSVEDAKVKKILRQLETISWFRNSKLHPKNMILHTVPVIPPDIRPIIQLDGAKFTTSDINNFYRRVIIRNDRLRRILEDGTVPSIVVNNEKRLLQESVDALFDNSSRHKPSLSKDKRSLKSLTDRLKGKQGLFRHNLLGKRVDYSGRSVIVVGPELKMYEVGIPALMILKLFKPFIIHGLINKFDENGNEIRPIAASIRQAEDMIKNQDDLIWGIVYDVIKDRPVLLNRAPTLHRLGIQAFEPRIVDGKAIRLHPLVTTAFNADFDGDQMAVHVPLSENAVNEARAVLLASKHILGLKDGRPIVTPTQDMVLGNYYLTTERKGQLGEGIIFSTVYEARAAYESQKVHLHAIVGISTKAFPNKKFACQGTLITTVGKIIFNDVLGNNVPYINDGEFDENACPEKFIVKQGEDVRQSILKHQIIPAFSKKVISKLIDLLYLLLEFKDLPKTLDNIKALGFKYSTFSSTTVSVFDIPKYTNKQNYFDSADQQVLKYKQFYNKGLLTDDERYKRVVKLWNNVKEKVSDEIQNLIKQEQYRDNSIVVMADSGARCNISNFTQLFGMRGLMSKSFNYERNNQSKIIKDTIEVPIKHSFFEGLTINEYFNSSYGARKGMTDTAMKTAKSGYMTRKLVDATHELIINHDDCGTRKGIVVEAIVETKTKSLIESLFDRIVNRYSITPIVDPETQKTIVEANSLITTQLAKQICATSIKEVLVRSVIYCERENGICQYCFGIDLSTGKLVELGTAVGVIAAQSIGEPGTQLTMRTFHTGGVSTENNLAQGFERLKQIFEVVTPKDFEKAVISEVKGTVKSITTVQNAQEVVIKSNVDERIYTIPFSAQIRVHVGDQVSPGSKITEGSVDIKQLLRIAGIQRVRQYMIVEIQKVYRIQGIDIADKYVEIIIRQLTNLLQVTDAGNSNLFVGQLVHSHYLNELNKSLLLAGKMPVIAINQVFGIDEAASKSNSFLSAASFQDTKKILTDAAVKNQVDYLLGLKENVIIGGKIPAGTGFLTDEELTFLGSKTVAEEY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: HEMH_SALA4
Sequence: MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYSREQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIRDYADDGAYIDALAKSARESFARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGREPWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIPALNATPEHIDMMLKLTAPYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_SERMA
Sequence: MSEQNSTEMAFQIQRIYTKDISFEAPNAPQVFQQEWQPEVKLDLDTASSQLADEVYEVVLRVTVTATLGEETAFLCEVQQAGIFSVAGIEGTQLAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAEGEGAAPHQDA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It specifically binds to its receptor SecA.  Also required for the secretion of HasA via an ABC transporter system.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_THET8
Sequence: MKDPKAPIGVFDSGVGGLTVLKALRRLLPREEFLYFGDTARVPYGGKPLAMVRRFAWEIAGFLLRQGVKAIVVACNTASSAALPDLAEDLSVPVFGVVEPAARAARGFRKVGLIGTQATVESGAYPRYVDLAWAKACPLFVPLVEEGLWDDPVALLVARHYLEDAPKDLEALILGCTHYPFLKGAIGAVLPGVALLDSAELTAQEVARALEAEGLLNPEGRGRTFHLVTGDPEAYRALAERLGERVEAVRRVSLEEL
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: GRC3_KLULA
Sequence: MSEDILTYTANTDSDDSDVEQREIEKKYKTSSETPVVQLYDGDDYDNDDIRETNGNDFPNEEDESNQLYSPVVDMNFFTLSDECTEVIICLEKNQHLLICGQFNLQIIKGGITYNNVHYNSGYKNWEFWHPACNAISPIVSSFYAGWESKLFLNREYQHFTTQIESYDCVLKISNGCNITELSSLLPELRDMWGPLNISLLPGIARKQLTFNIISKISDSVRILDISTEWSTVIDEMRIFHANSSQDMRVMVIGGKNSGKSTLMRLLVQKFLHSNNDLSYEAIHYLDIDPGQPEYSPPESISWNKVDPKSMSLGQHLCQGRFTTIKQHFIGSSSPQDWPETYSNAVESLLKEWQTENFMGTSFLNIPGWIKGFGVKIINHALDHFKPTHIIFLSYNGLPFSSEIKVPDAFSTTQRSTYKPIILQLHSPAVGKHISHALQRFNAAKIRQFKITAYLHKKYDRNFVINPLVMQKPQLTSIGNRGIVGFEFLQYSNSSLYHDDIKLSLDGTVVALHRADSTPDVLFKGIFPVMKNYSKINTEFVGLALIHSIDLEQSLIYMYIPENLFRALRETENKWVLVRGKTETPICELYPNNGIFKSEVDIPYVSLYQKKRHEHVWKVRKNVMRRGHHMK
What is the function of this protein?
Polynucleotide 5'-kinase involved in rRNA processing.
What are the official names of this protein?
Polynucleotide 5'-hydroxyl-kinase GRC3.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. NOL9/GRC3 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: Y101_ENT38
Sequence: MDDELTLLPREKMLSFGITSLTDAELLALFLRTGTSGKSVFVLAQELLQHFGSLHGLLNANLDEFRYVEGIGLAKYAQLKGIAELARRYHSVRVLGDNPLLSPEMTKDFLQSQLSDAEREVFMVIFLDNQHRVVKHSRMFSGTLRHVEVHPREIVREAIKVNAAAVILAHNHPSGCAEPSKADKDITERIIKCCQFMDIHVLDHFIIGRGEYVSFAEQGWI
What are the official names of this protein?
UPF0758 protein Ent638_0101.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family. YicR subfamily.
Protein: HIS4_METAR
Sequence: MSFNVIPAIDLKGGKCVQLVQGVPGTEMVSIDDAVEVAAGWVGQGAKTLHIIDLDGAFSGSRKNAYIMEDIVSKFDVDVQVGGGIRDYETAKYLLSLGIDRVILGTAAIKNPDLVRQLADEFGSETVMVSLDSKQGEVVIEGWTESSGKTTNEMGKFFSEIGAGSILYTNVDVEGLLKGVNEDPVRSLVNSVTIPVIASGGVAKIDDLVKIKNTGAAGVVVGSALYKGLFTLREAIDKVS
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AL1A1_MOUSE
Sequence: MSSPAQPAVPAPLADLKIQHTKIFINNEWHNSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATMEALNGGKVFANAYLSDLGGCIKALKYCAGWADKIHGQTIPSDGDIFTYTRREPIGVCGQIIPWNFPMLMFIWKIGPALSCGNTVVVKPAEQTPLTALHLASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVKRSVERAKKYVLGNPLTPGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSVDDVIKRANNTTYGLAAGLFTKDLDKAITVSSALQAGVVWVNCYMMLSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS
What is the function of this protein?
Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12851412).  Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:12851412).  This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable).  Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic.  By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:17567582).  Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity).  Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (PubMed:26430123).
What are the official names of this protein?
Aldehyde dehydrogenase 1A1, 3-deoxyglucosone dehydrogenase, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, RALDH 1, RalDH1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell projection, axon.
Protein: HSLU_PARDP
Sequence: MSDLTPREIVSELDRFIIGQRDAKRAVAVALRNRWRRRQLGDDLRDEVYPKNILMIGPTGVGKTEISRRLARLARAPFLKVEATKFTEVGYVGRDVEQIIRDLADAAVIETRERMRDEVKARAHKSAEDRVVAALAGEGAREQTREMFRDKLKRGELDDKVIELELQDNSSPFGMMEIPGQPGQPMGGMMDLSGLMKAFGGRRVRRKLSVAESYDLLIAEEADKLLDDEAVKAAALEAVQENGIVFIDEIDKVAARTDARGGDVSREGVQRDLLPLIEGTTVSTKYGPVRTDHILFIASGAFHIAKPSDLLPELQGRLPIRVELRALTEEDFIRILTETDNALTRQYTALMATEGVTVQFIQDGIRALARIAAEVNGSVENIGARRLYTVIERVFEELSFSAPDRSGETVVVDAAFVEKHLGDLSRSTDLSRYVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GIP2_YEAST
Sequence: MYIKAEQKPQQFERKNEKLDRNKNQQLPDLETDFKGYRVNSDLYNKERDGSTEETLNSLKFLHKPQRVTQMRANRFPEEEVQRNTDLNKRIFSAGNDENVDNESGWSKIAAAKNHTSVESLNGSTRPPFKIELPPLSPKSTVPKSFQAEYPEAKSPGNDMNFEYDEEILIPFAPPVYKKSGELLKSSLKRRSKSLPTTPGIRSGNGVQARDGSPMLIRSKSVHFDQAAPVKYFAEDESPINVNKTEQHDNCLSFKHKPVNLMVDPEEETKMLSSGLETTSIDDDLTTVAPKGFAHPAKISNPNNGKGTNNTKLRKSKRFQNLLKNRTDMPPSKSNKKFVNGGGAHEISDRNSKNYHVVGLYSKNFPILSNKNPKSLKLNIFINLSQNKKVFLQELSLYIHRDNNYFSNSSSFYNIPNSHNGNDCNGVAKGYNAGCTRLIAGRILVKNIFYDKRVVVRYTWDSWRTTHEVECVYISDGDGILPGTNMDIFHFIIDDVSKVDPRGKLEFCIHYSTRNDYEREEYWDNNNGNNYKVDVVMDGFNDPFAAAA
What are the official names of this protein?
GLC7-interacting protein 2.
Protein: MSRA_CAMJJ
Sequence: MKNIVLGGGCFWCVEAVFERLKGVIDTEVGYSGGNPNPSYESVCNGDGNIEVVKINYDEKQISLLEILTLFFKIHDPTSIDKQGGDIGIQYRSIIFYENEEDKILAQNFIEEQQKIFSKKIVTKISRLQTYYKAENYHQHYFINNPNQGYCQAVIAPKLQKIQSD
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: CREA_ASPFN
Sequence: MPPPASSVDFTNLLNPQNNETGSAPSTPVDSSKAPSTPSSTQSNSTMASSVSLLPPLMKGARPATEEARQDLPRPYKCPLCDRAFHRLEHQTRHIRTHTGEKPHACQFPGCTKRFSRSDELTRHSRIHNNPNSRRSNKAHLAAAAAAAAAGQENAMVNVTNAGSLMPPPTKPMTRSAPVSQVGSPDVSPPHSFSNYAGHMRSNLGPYARNTERASSGMDINLLATAASQVERDEQHFGFHAGPRNHHLFASRHHTGRGLPSLSAYAISHSMSRSHSHEDEDGYTHRVKRSRPNSPNSTAPSSPTFSHDSLSPTPDHTPLATPAHSPRLRPLGSSELHLPSIRHLSLHHTPALAPMEPQPEGPNYYSPSQSHGPTISDIMSRPDGTQRKLPVPQVPKVAVQDMLNPSAGFSSVSSSTNNSVAGNDLAERF
What is the function of this protein?
Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter.  Also plays a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).
What are the official names of this protein?
Probable DNA-binding protein creA, Carbon catabolite repressor A.
What is the protein family that this protein belongs to?
Belongs to the creA/MIG C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RF1_PARUW
Sequence: MMEKKVHELLERLAEVEEVLGNPHVYDDQKKYRALTQEHAYLNNLKKSWDEKKDLEKQLEDNQELLKIEKDLEFAEVLKDDIRQLQSRVQELQLLIENLLVPPDPLDNRPSIIELRAGTGGDEAALFVGDCVRMYKLFADRKGWRYELLSCTPSEMGGFKEYVMVLSGENVYRFMQYEAGTHRVQRVPATEAQGRVHTSAITIAVLPEPDENEEIDLDEKDLRIDTYRSSGAGGQHVNTTDSAVRITHVPSGIVVYCQEERSQHKNKDKAMRLLKAKMAEIEQQKKQQELASTRAQQVGSGDRSERIRTYNFPQNRITDHRINLTKYNLDYVINGDLEEITSALVAYFHQEKLKTSREE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFH2_METIV
Sequence: MSKRIAIYGKGGIGKSTIVSNIAAAYSKDYNVLVIGCDPKADTTRTLIGKRLPTILDIVKKKKNASIEEVLFEGYGNVKCVESGGPEPGVGCAGRGVIVAMGLLDKLGTFSDDIDIIIYDVLGDVVCGGFAVPLREDFADEVYIVTSGEYMALYAANNICRGIKKLKSNLGGIICNCRGIENEVQIVSEFAGKVGSKVIGIIPGSEMVQKSEIDAKTVIEKFGESEQADLYRELAKSIYSNEDFVIPEPMGVDEFDEFFRGFQ
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein 2, Nitrogenase Fe protein 2, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: YACG_RUEPO
Sequence: MTCPICGSKTAPSYRPFCSKRCADLDLAKWLNGSYAIPASSEDEEEPLDQEAETPVAPRH
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: UBP20_DANRE
Sequence: MTDSGDLCPHLDSIGEVTKEELIQKSKGTCQSCGVGGPNLWACLQCDCPYVGCGESYSDHSTIHAQAKKHNLTVNLTTFRVWCYVCEREVFLEPKPVTPVSSAHRCKPHDQDPVSQTTCYPLKAVPIAVADEEGSESEEDELKPRGLTGMKNIGNSCYMNAALQALSNCPPLTQFFQDCSGLVRTDKKPALCKSYQKLISELWHKKRPSYVVPTTLFHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPLFDCSGGISEVEPDLSLDSCNLVDGDRSPSEDEFLSCDSGSGSERGDGERAGGEAELLIQDECVAVRGTGGISEKERLKERRGEERTREMDEDADVDTAAQDGQAERETETATPATAVPAPGNTEPDNEASMHCPSSRPCSPAHSVQELHSRLSSNPPRSSPLRTGPTYTFKKAQMLLSTKKKKQSRFRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSSIHQSAPVKAGVCTDGYAAQGWISYIMDSIRRFVVSCIPSWFWGPMVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLKPFLAKESPSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEAYVLFYRKSSEESVRERQRVVALANLKEPSLLQFYISREWLNKFNTFTEPGPITNHTFLCQHGGIPPTKYHYVDDLVVILPQNVWEYLYNRFGGGPAVNHLYVCAICQVEIETLAKRRKLEIDTFIKLNKEFQAEEAPTVILCISMQWFREWENFVKGKDNEPPGPIDNSKIAVMKGGHIQLKQGADYGQISEETWQYLLSIYGGGPEIAVRQTISPPDTDTHGERKIEAETRAL
What is the function of this protein?
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (adrb2) recycling.  Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (adrb2).  Plays a central role in adrb2 recycling and resensitization after prolonged agonist stimulation by constitutively binding adrb2, mediating deubiquitination of adrb2 and inhibiting lysosomal trafficking of adrb2.  Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 20, Deubiquitinating enzyme 20, Ubiquitin thioesterase 20, Ubiquitin-specific-processing protease 20.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP20/USP33 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: CLPX_STRE4
Sequence: MAGNRSNDIKVHCSFCGKSQDEVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLEILNQYVIGQERAKRALSVAVYNHYKRISFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENILLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMVQIDTKNILFIVGGAFDGIEEIVKQRLGEKIIGFGQNSRKIDDNASYMQEIIAEDIQKFGLIPEFIGRLPVVAALEQLNTEDLIRILTEPRNALVKQYQALLSYDGVELEFEKGALEAIAGRAIERKTGARGLRSIIEETMLDIMFEVPSQEEVIKVRITKEAVEGQSKPILEIA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: 2SSL_RICCO
Sequence: QDYCAQEGQQEVQRKDLSDLERYLRQSRQR
What is the function of this protein?
This is a 2S seed storage protein.  Inhibits spore germination in R. solani and F. oxysporum.  Exhibits anti-trypsin activity.
What are the official names of this protein?
2S seed storage-like protein, 2S albumin storage-like protein, Rc-2S-Alb.
What is the protein family that this protein belongs to?
Belongs to the 2S seed storage albumins family.
Protein: RSC6_YEAST
Sequence: MVTQTNPVPVTYPTDAYIPTYLPDDKVSNLADLKKLIEMDSRLDLYLTRRRLDTSINLPTNTKTKDHPPNKEMLRIYVYNTTESSPRSDSGTPADSGKTTWTLRIEGKLLHESANGKHPFSEFLEGVAVDFKRLKPLGMGKKRKRDSSLSLPLNLQQPEYNDQDSTMGDNDNGEDEDSAEAESREEIVDALEWNYDENNVVEFDGIDIKRQGKDNLRCSITIQLRGVDGGKVQYSPNLATLIGMQTGSVNDAVYSIYKYILINNLFVTEQTEAQDGSNDAEDSSNENNNKNGAGDDDGVEGSTPKDKPELGEVKLDSLLQKVLDTNAAHLPLMNVVQTVNKLVSPLPPIILDYTIDLSKDTTYGATTLDVDVSHILHQPQPQPNLQKEEETDAEDTAKLREITKLALQLNSSAQKYQFFHELSLHPRETLTHYLWSSKQNELVLQGDQYFNEDAARTSDIYSNNNNDRSLMGNISLLYSQGRL
What is the function of this protein?
Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA.  The reaction requires ATP and involves an activated RSC-nucleosome intermediate.  Remodeling reaction also involves DNA translocation, DNA twist and conformational change.  As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.  This subunit is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.
What are the official names of this protein?
Chromatin structure-remodeling complex protein RSC6, Remodel the structure of chromatin complex subunit 6.
What is the protein family that this protein belongs to?
To yeast SNF12.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
Protein: APOC2_GRASU
Sequence: MGSRFFLALFLVLLVLGNEVQGTQEDDPSSPALLDTMQESFFSYWSSARAAAEGLYQKTYLTSVDEKLRDMYSKSSAAMSTYAGIFTDQLLTLLKGE
What is the function of this protein?
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma.  Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
What are the official names of this protein?
Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNH2_STAAM
Sequence: MTLTIKEVTQLINAVNTIEELENHECFLDERKGVQNAIARRRKALEKEQALKEKYVEMTYFENEILKEHPNAIICGIDEVGRGPLAGPVVACATILNSNHNYLGLDDSKKVPITKRLELNEALKNEVTAFAYGIATAEEIDEFNIYKATQIAMQRAIDGLSVQPTHLLIDAMTLDNALPQVSLIKGDARSVSIAAASIMAKVFRDDYMTQLSKDYPEYGFEKNAGYGTKQHLLAIDDIGIMKEHRKSFEPIKSLL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_XYLFA
Sequence: MAHKKGVGSSRNGRDSNPKYLGVKLFGGQAIEAGNIIIRQRGTQFHAGDGVGLGRDHTLFALVDGTVAFSIKGPKKRRTVNVIPA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RS15_THEVO
Sequence: MARMHTRKRGKSGSKKVYGVEPNWVQYSKDEILNIAVDLKKSGMTSSVVGIRLRDQYGVPTVKAIFGKKLNKLLAEKGIRDEIPEDLNSLIKRYNNVAKHVELNPKDHSNKRGRDLIMAKMLRLVRYYKRTGVLDQKWNLSKVLR
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: KAX52_ANDMA
Sequence: TVCNLRRCQLSCRSLGLLGKCIGVKCECVKH
What is the function of this protein?
Blocker for the small conductance calcium-activated potassium channels (PubMed:8385026, PubMed:8457543, PubMed:11527975).  Shows similar affinities for KCa2. 2/KCNN2 (Kd=22 nM) and KCa2. 3/KCNN3 (Kd=25 nM) (PubMed:11527975).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 5.2, AmPO5, P05, PO5, Leiurotoxin I-like toxin P05.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 05 subfamily.
What are the subcellular locations of this protein?
Secreted.