PharMolix/UniProtQA huggingface dataset:
Protein: RL29_METTH
Sequence: MAILRSEEIREMDGEELQKKLDELKAEYARYISKSAAAGIHENPGKMREIRRTIARVLTIMNEK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: ACHA5_PANTR
Sequence: MATRGSGPRAPRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSVRCITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-5.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: CDC61_SULAC
Sequence: MSDIIDSILSTLKKGRIFRSRDLLLPDYIPEALPHREDQIRKLVEILAPITRSEKPSNVFIYGLTGTGKTAVTRFVLSNLQRKFPSKFTFIYINTRQNDTPYRILADVLEALGIRVPFTGLSTAELFKRFVKRLNTFQTIVLITLDEIDALVKKHGDDILYRLTRINYDLSTSKVSVIGITNDVKMVENLDPRVKSSLGEEEIIFPPYNAEQLEDILKQRSKIALNEGVISEEVIKLCAALAARDHGDARRALDLLRVSGEIAEREGRDLITADDVNRARIELERDRVYEVISTLPFHSKLVLISIVLGLNSNSTLTTGEVYDIYIKLAGKLGVESITQRRVSDIINELDMVGIITARVVNRGRYGKTKEISLAVSKDIVIKSIKESDERIGSLWSR
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 1.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: LIPB_FRACC
Sequence: MARMRVMVRERIDGVRPDTLWFLSHPPVYTVGKRTPPEHRPLAGLGIPVHETNRGGLLTYHAPGQLVGYVMCHIGAMNAVVPFLRLLEARLVDTVEALGIPAERRDTPPGSVELTGVWTRRTNRKIASIGLRCTRKVTSHGFALNVDCDMRPWTWATPCGMPEVEMTSVQRELTDAGHAVPSMAEVREIAAEMLGARNAPHPPAPNLSSGDLGTGTRAGRT
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KEFF_SALNS
Sequence: MILIIYAHPYPHHSHANKRMLEQAGTLENVEIRSLYHLYPDFNIDVAAEQEALSRASLIVWQHPMQWYSVPPLLKLWMDKVLTHGWAYGHGGTALHGKHLLWAVTTGGGENHFTIGSHPGFDVLSQPLQATALYCGLKWLPPFAMHCTFICDDDTLQAQARQYKQRLLAWQEVNHG
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefC.  Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefF, Quinone oxidoreductase KefF.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL25_NITMU
Sequence: MQIEISAEKRELQGKGASRRLRGSGKVPGIIYGGENPAQPIELDHNNLYHQLKLEAFHASILTMSVEGQKEKVLLRDIQMHPFKPQVLHIDFQRVASNKKIHMKVPLHFINEDIAPGVKLAGGLVSHVLTELDVSCLPKDLPEFISVDVGELAAGNTIHLSNLQLPEGVEIPALMKGEDLPVATIAIPRGVAAEEAAGGVAAGDIPTSVQKKEGVAKEGEKKDAGKKK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: QCR6_MACFA
Sequence: MGLEDERKMLTESGDPEKEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDKRVSSRSRTEEDCTEELLDFLHARDHCVAYKLFNNLK
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 6, mitochondrial, Complex III subunit 6, Complex III subunit VIII, Cytochrome c1 non-heme 11 kDa protein, Mitochondrial hinge protein, Ubiquinol-cytochrome c reductase complex 11 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the UQCRH/QCR6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: RS21_STRPD
Sequence: MSKTVVRKNESLDDALRRFKRSVTKAGTLQESRKREFYEKPSVKRKRKSEAARKRKKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: KINH_MOUSE
Sequence: MADPAECNIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTADKDIAITSDKPAAAVGMAGSFTDAERRKCEEELAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLEQERLRVEHERLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEVDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPGTVRGGGSFVQNNQPVGLRGGGGKQS
What is the function of this protein?
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.  May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence (PubMed:9657148).  Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (PubMed:21976701).  Regulates centrosome and nuclear positioning during mitotic entry.  During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes.  Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).  Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends.  Involved in NK cell-mediated cytotoxicity.  Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity).
What are the official names of this protein?
Kinesin-1 heavy chain, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytolytic granule membrane. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Uniformly distributed between soma and neurites in hippocampal neurons.
Protein: Y4CE_SINFN
Sequence: MGLRDPGAKRACPTFAGRKRHVVKIDTNTFKFGFLNPQVRLYGYHQIRLVIRYGNIGRSTRLGRLLGKLSAAECDALDLELNKLRANESLDPQESELVLGRVLEPLFGIEGYEVEHTGGLNDQGIDFRASRTADETSSAPAETIGVQAKFYRKTVSRVGMADLQKLIGAALLQDLTRVVLVSNGEFPREAHAAVEKSLPLRIELLDIGGMRAWISRLREEKVDVEAEVRIMLRDLSSGLARLIAKSPDALDHLEWRMVEQVVAEVFEGLGFAVTLTPGSKDGGKDVILTCTVRGKLAEYYVEIKHWRSSTKVGSAAVEKLLKIIVEEKKDGGLFLSTYGFTSNAFEQLTTIAKHKLKFGDQEKIVTFCQTYVKAKAGLWSPPENLTEVLFA
What are the official names of this protein?
Uncharacterized protein y4cE.
Protein: RF1_SHIDS
Sequence: MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRP1_HHV1F
Sequence: MLSGIGGQAARAAALWLTPEPAQHGTPTPTHPHSHAPPLPRTPTPSHPHSRAPPLPRAPTPTHPHSHAPPLPRTPEIHPTQTGKRYKSKPLFPNRQQKSPEFFIRANTKDPLVCGARVFHFSPPRHGLAGVVGAARDHPAPDPPLPTNTGGVPYCFPSSRVDAPCSPDHGCRDRRLRKSRAPTRVPWSNSMFPTGVIQRLFHSDAGAVGYSGGITWLPAVSGSRVRRLQPGTAARSRVAMFPVWSTRTTLRVARLPGTLPRPPRPRSSAGAEGGFLLSPSQGTDGPARGGGSGGGRGPGGGRGGPRGSRGRGGRGRGGRGGGRRGRQGGPGPTLAAPPRP
What are the official names of this protein?
Latency-related protein 1.
Protein: TREA_SALCH
Sequence: MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQNAKLLPDQKTFADAIPNSDPLMILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQSLREHIDGLWPVLTRSTKNVKKWDSLLPLPESYVVPGGRFREIYYWDSYFTMLGLAESGHWDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMVELLAQHEGDDALKEYLPQLQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASAAAGDRAKASQYDALANARQKAIEMHLWNNKEGWYADYDLQNNKIRDQLTAAALFPLYVNAAAKDRAAKVAAAAQAHQLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVAMEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDSVPSTRPASLSATPTKTPSAATQ
What is the function of this protein?
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
What are the official names of this protein?
Periplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PUUD_SHISS
Sequence: MENIMNNPVIGVVMCRNRLKGHATQTLQEKYLNAIIHAGGLPIALPHALAEPSLLEQLLPKLDGIYLPGSPSNVQPHLYGENGDEPDADPGRDLLSMAIINAALERRIPIFAICRGLQELVVATGGSLHRKLCEQPELLEHREDPELPVEQQYAPSHEVQVEEGGLLSALLPECSNFWVNSLHGQGAKVVSPRLRVEARSPDGLVEAVSVINHPFALGVQWHPEWNSSEYALSRILFEGFITACQHHIAEKQRL
What is the function of this protein?
Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma-aminobutyrate.
What are the official names of this protein?
Gamma-glutamyl-gamma-aminobutyrate hydrolase, Gamma-Glu-GABA hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C26 family.
Protein: RSMA_DECAR
Sequence: MKGHVARKRFGQNFLVDQGIIAAIISAVDPKRDETVVEIGPGLGAITEPLMARVDHLHVIEIDRDLIARLKKQHTPERMTVHEGDALAFDFASIGKNLRLVGNLPYNISTPLLFHLAEYVDVVHDMHFMLQKEVVERMVAEPGNADFGRMSVMLQYRFYLEWLIDVPPESFDPPPKVQSAVVRLIPKPVSELNAKSQEKLSQVALTAFSQRRKMLRNTMKTLLSDAAFTELGIDPTCRPEDVSVEDYVRIANYLS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RENT1_DANRE
Sequence: MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTQGQTQSQLDNQVNGPDGVLPNGEDAVGKTSQLLAELNFEEDEEDTYYTKDLPVHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKENPTATLEDLEKPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGDMRLMQGDEICLRYKGDMAPLWKGIGHVIKVPDNYGDEIAIELRSSAGAPVEVPHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSSSDEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRLKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTRLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMSTAMYDAREAMIPGSVYDRSSTGRPSNMYFQTHDQVGMIGTGPNPMGSLNIPIPFNLVMPPMPPPGYLGQVNGPAAGRGAPKGKTGGRGGRQRNRGTGNHGSGQPNMPNSQASQDLVSQPFSQGPLTQGYITMSQPSQMSQPGLSQPELSQDSYLGDEFKSQMDVALSQDSTYQGERAYQHGGVTGLSQY
What is the function of this protein?
RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD.  The formation of an upf1-upf2-upf3 surveillance complex is believed to activate NMD.
What are the official names of this protein?
Regulator of nonsense transcripts 1, ATP-dependent helicase RENT1, Nonsense mRNA reducing factor 1, NORF1, Up-frameshift suppressor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body. Nucleus. Cytoplasm, perinuclear region.
Protein: METJ_ECOLI
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGINPETWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.  It is also autoregulated.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_CAUSK
Sequence: MTDILAKIAAYKREDVADRKRRRSIAQLEAAAKAANSPRGFKAALEADHAPGKLALIAEIKKASPSKGLIRADFDPPALARAYAAGGASCLSVLTDGPSFQGADGYLIDVRAAVSLPCIRKDFLVDPWQVAESRALGADAILVILAMIDDAVAADLMSEAARLGMDALVEVHDEAEMERAGKLGSTLVGINNRDLKSFVVDLAVTERLAVQAPSDALLVTESGLFVAADVARMEAAGAKAMLVGESLMRQADVAAATRALLG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: CRAC1_XENTR
Sequence: MMLPADFFVPVSKMMLLALLLSIIICCGGAQRSEPMFTAVTDTVLPQDYDSNPTQLNYGVAITDVDNDGDFEVVVAGYNGPNLVLKYIKEKGHLVNIAVDERSSPYYALRDRQGNAIGVAACDIDGDGREEIYFLNTNNAFSGIATYSDKLFTFRNGRWEDLFSDEVNLRRGVANRFSGRSVACIDRKGSGRYSFYIANYANGNVGPHALIELDETASNLSRGIIVLSNVAAELGLNKYTGGRGIAVGPIVNSAASDIFCDNENGPNFLFQNKGDGTFVDIASSTGVDDVYQHGRGVALADFNRDGKVDIVYGNWNGPHRLFLQMNTNGKVRFRDIATQKFSMPSPIRTVIAADFDNDQELEVFFNNIAYRGPSANRMFRVGRREHADPFMEELNPGDASEPDGRGTGGAVTDFDGDGMLDLILSHGESMAQPLSVFKGKQGLKNNWLRVIPRTKFGAFARGAKVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGKDEASSLEVTWPDGKIFTRSVAEGEINSVLDIAYPHEDDTVTKPTDIECGQGFSVNENGRCTDTDECIQFPFVCPREKPVCINTYGGYKCRPNRRCSRGFEPNEDGTACVAQVAYFGSYPSSASRSQALFLHCTASLLGLGFYFQIYTL
What are the official names of this protein?
Cartilage acidic protein 1, ASPIC.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: METE_BIFLS
Sequence: MSTLTSVSGFPRIGQNRELKKIIEGYWKGANDLAAVKATAAELRAKHWRLQQAAGIDLIASNDFSYYDQMLDTAILLNVIPQRYQRLAFDDQEDTLFAMARGYQGDKGDVTALPMKKWFTTNYHYLVPEVEPSAEIKLNSTKPFDEFNEAKSLGVETKPVFIGPYTFLKLARTPEAAELEIDKGLVNAVAAVYAEVLARFNDLGAAWVQLDEPYLVLDKEPGDVELFKALYTKILPAKGNVKVLLNTYFGHIADVYETVNLFGFDGIGLDLNEGREENLEAVAKYGVAAGTTIFAGVINGRNIWRNNYATSLGLVDALKQVTADVAVSTASSLLHVPFSTEGETGIPAEDLKHFAFAVQKLGELKEIAALTDATEDEKKSSAALAANQALFDGTRVAADPAVAERIGKLSDADYVRQPAREERQSLQREALGLPLLPTTTIGSFPQTKEIRAERAKLRKGEVTKEAYDEFIASQIDAVIRKQEEIGLDVLVHGEFERNDMVEYFGQNLNGFLFTKNAWVQSYGTRCVKPPIVWGDVSRANPITVEWSAYAQSKTDHVMKGMLTGPVTILNWSWPREDITHEEQTKQLALAIRDEVLDLEAAGIKIIQIDEAALREKLPLRKSDWHAKYLDWAIPAFRLVHSAVKPTTQIHTHMCYSEFNDIIRDIDAMDADVISFEASRGDLVVLDAIHDARFETEAGPGVYDIHSPRIPSEKEIEDRIYEILDKIDVKKVWINPDCGLKTRGNDETWPSLEHLVAAAKAVRARLDK
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: MRE11_CAEEL
Sequence: MCGSDDSFDDFVPDSQEPASSRTRNQDHLDDDEVPCSQRPDAANDTMVEDLDEGDEPAHDESEDIIKILVATDIHCGYGENKANIHMDAVNTFEEVLQIATEQKVDMILLGGDLFHENNPSREVQHRVTQLLRQYCLNGNPIALEFLSDASVNFNQSVFGHVNYYDQNLNVGLPIFTIHGNHDDLSGKGLTALDLLHESGLVNLFGKHSNIQEFIVSPILLRKGETRLALYGIGSQRDDRLVRAFKNNSISFLRPNAGAEDWFNLFVLHQNRPRRAMHRSTGNFLPESLIPQFFDLLIWGHEHECKPDPQYVASSEAVGDGFYILQPGSTVATSLTPEEALQKNAFLIKIKGRKFASKPIPLQTVRPMVCDELLLDKIPPGSRPILKTDRPKHTDGRYIDEIAIEAKINEMITTAKAKRRPRQPELPLIRLKVIYDGDWLNITPANAKRIGLRYENVVANAVDMVFIKKNNKPKEGKLQTENEKNITEMADEMGQVSATNLQTIINDYFINQPLVDQMTVLKPIGIGRALEQYSAIEEGGLATSANRNFDSCLMHQIDVVRKTLKKMPLPPINDPSDLDKFRDLITKDLYDMKKADSERFKNPVADVEMEEDEDDPQYYMPPQSTSRTNYASGSEDEVANSDEEMGSSISRHSKQPTTRGRGRGARGAGASRETTRGRSNKVVSTRQIDSDGFEIINDSPSPPPASRSTRGKARGKSAPSKKRDLSFF
What is the function of this protein?
Required for meiotic crossing over and chiasma formation.  Pachytene morphology and homolog pairing are normal.  Vital in long term for maintenance of reproductive capacity of subsequent generations.
What are the official names of this protein?
Double-strand break repair protein mre-11.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
Protein: NTPPA_CHRVO
Sequence: MSTNDTRIYLASGSPRRREILEQLGLHLERIHADIDESVRPGEDAVAYTERLAREKAEAGWRVVSSCGLPERPLLAADTTVSQDGEIFGKPEDADDARRMLRAFSGRSHQAITSVAVRDGGKLLVKTSITDVFFKSLSDAEIERYIASGEPFDKAGAYGIQGKAGVFVEHIEGSYTGVMGLPVHETALLLAEFGFELP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FNIP2_HUMAN
Sequence: MAPTLLQKLFNKRGSSGSSAAASAQGRAPKEGPAFSWSCSEFDLNEIRLIVYQDCDRRGRQVLFDSKAVQKIEEVTAQKTEDVPIKISAKCCQGSSSVSSSSSSSISSHSSSGGSSHHAKEQLPKYQYTRPASDVNMLGEMMFGSVAMSYKGSTLKIHYIRSPPQLMISKVFSARMGSFCGSTNNLQDSFEYINQDPNLGKLNTNQNSLGPCRTGSNLAHSTPVDMPSRGQNEDRDSGIARSASLSSLLITPFPSPSSSTSSSSSYQRRWLRSQTTSLENGIIPRRSTDETFSLAEETCSSNPAMVRRKKIAISIIFSLCEKEEAQRNFQDFFFSHFPLFESHMNRLKSAIEKAMISCRKIAESSLRVQFYVSRLMEALGEFRGTIWNLYSVPRIAEPVWLTMMSGTLEKNQLCQRFLKEFTLLIEQINKNQFFAALLTAVLTYHLAWVPTVMPVDHPPIKAFSEKRTSQSVNMLAKTHPYNPLWAQLGDLYGAIGSPVRLTRTVVVGKQKDLVQRILYVLTYFLRCSELQENQLTWSGNHGEGDQVLNGSKIITALEKGEVEESEYVVITVRNEPALVPPILPPTAAERHNPWPTGFPECPEGTDSRDLGLKPDKEANRRPEQGSEACSAGCLGPASDASWKPQNAFCGDEKNKEAPQDGSSRLPSCEVLGAGMKMDQQAVCELLKVEMPTRLPDRSVAWPCPDRHLREKPSLEKVTFQIGSFASPESDFESRMKKMEERVKACGPSLEASEAADVAQDPQVSRSPFKPGFQENVCCPQNRLSEGDEGESDKGFAEDRGSRNDMAADIAGQLSHAADLGTASHGAGGTGGRRLEATRGLYVKAAEGPVLEPVAPRCVQRGPGLVAGANIPCGDDNKKANFRTEGDIPRNESSDSALGDSDDEACASAMLDLGHGGDRTGGSLEVELPLPRSQSISTQNVRNFGRSLLAGYCPTYMPDLVLHGTGSDEKLKQCLVADLVHTVHHPVLDEPIAEAVCIIADTDKWSVQVATSQRKVTDNMKLGQDVLVSSQVSSLLQSILQLYKLHLPADFCIMHLEDRLQEMYLKSKMLSEYLRGHTRVHVKELGVVLGIESNDLPLLTAIASTHSPYVAQILL
What is the function of this protein?
Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913).  In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913).  Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913).  Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726).  In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135).  Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135).  Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135).  May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity).
What are the official names of this protein?
Folliculin-interacting protein 2, FNIP1-like protein, O6-methylguanine-induced apoptosis 1 protein.
What is the protein family that this protein belongs to?
Belongs to the FNIP family.
What are the subcellular locations of this protein?
Lysosome membrane. Cytoplasm. Note=Colocalizes with FLCN in the cytoplasm.