PharMolix/UniProtQA huggingface dataset:
Protein: TIM54_CANGA
Sequence: MNPALKALGLGNFKLPSRNWTIFWTVLAGSLGGVGYDKYQQRQIISRYCDEVKPLSLQHCDVNKSPRKITVFIAPPPNDYLETSLKIWRRYIKPVLYYAGLDYEVIEEDRQGIIRSEVASRIRQLRRELLEADNEQQGNSGDSLLSIFKKPHAKDPEEEQKFDPEQARQFKADFDFRNVMGIYTKVPKLDTIVQTDSLVADPVLAGGVVCVGRGAYKEYITGLHEGLLGPLDPPEETTQEVEMGSKLKSMNDGDNVETTVETAVETMVETTLESADKVEVEGKDTENEEGKDEPDEEKSRVLKPYLLRTAFHDTPIPPEVEPVLEKDALLKDPKTNVPSLLHQPVLVIPVPNLIGFLTIPERIYRFYQRRFFVDEVCREASNLVKQEHIVKYEPDKHINLALEEESDWPKQWVKTGIEKNSEWTQELVQDQRVVSKMHVFELPKHTTKDTKE
What is the function of this protein?
Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM54.
What is the protein family that this protein belongs to?
Belongs to the TIM54 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ERD2_KLULA
Sequence: MLNVFRIAGDFSHLASIIILIQSITTSNSVDGISLKTQLLYTLVFITRYLNLFTKWTSLYNFLMKIVFISSSVYVIVLMRQQKFKNPVAYQDMITRDQFKIKFLIVPCILLGLIFNYRFSFIQICWSFSLWLESVAILPQLFMLTKTGKAKQLTSHYIFALGLYRALYIPNWIWRYYTEERFDKLSVFTGVIQTLVYSDFFYIYYQKVIKLGGDLELPQ
What is the function of this protein?
Required for the retention of luminal endoplasmic reticulum proteins.  Determines the specificity of the luminal ER protein retention system.  Also required for normal vesicular traffic through the Golgi.  This receptor recognizes H-D-E-L and D-D-E-L, but not K-D-E-L.
What are the official names of this protein?
ER lumen protein-retaining receptor.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MS57C_DROME
Sequence: MHGTHFLILLLLCGVLGSNGVTPDIKNVAKAERNMHNMLRCLKKNEPIVKSRILTLPPNCNQYVSAVVETWKPEGV
What is the function of this protein?
Transferred from male to female during mating and may affect egglaying and behavior after mating.
What are the official names of this protein?
Accessory gland-specific peptide 57Dc, 45 kDa cAMP-dependent phosphoprotein, Male accessory gland secretory protein 57Dc, Pp45.
What are the subcellular locations of this protein?
Secreted.
Protein: FKBP7_HUMAN
Sequence: MPKTMHFLFRFIVFFYLWGLFTAQRQKKEESTEEVKIEVLHRPENCSKTSKKGDLLNAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTDMCPGEKRKVVIPPSFAYGKEGYAEGKIPPDATLIFEIELYAVTKGPRSIETFKQIDMDNDRQLSKAEINLYLQREFEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYNVYQHDEL
What is the function of this protein?
PPIases accelerate the folding of proteins during protein synthesis.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP7, PPIase FKBP7, 23 kDa FK506-binding protein, 23 kDa FKBP, FKBP-23, FK506-binding protein 7, FKBP-7, Rotamase.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: SYL_HALH5
Sequence: MSFSHREIESKWQKYWEENKTFKTEEDETREKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYAIDTGNSPAEFTEKNINTFRRQIKSLGFSYDWDREVNTTDPDYYKWTQWIFIQLYNKGLAYIDEVAVNWCPALGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITEYADRLLEDLEELDWPESIKDMQRNWIGRSEGAEVTFSVDGHDDTITVFTTRPDTLFGATYMVLAPEHKLVDAITTSEQKQAVESYKKEVATKSDLERTELAKEKTGVFTGAYAINPVNGEKVPIWIADYVLVSYGTGAIMAVPAHDERDYEFAKTFDLPIKEVVSGGVIEQEAYTGDGPHVNSEFLNGLSKEEAIEKMIQWLEAEKKGTKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMSTVPEDELPLELPKMSEIKPSGTGESPLANATDWLEVVDPVTGKKGRRETNTMPQWAGSCWYYLRYIDPDNERMIADPEKLKKWLPVDIYIGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLYNQGMILGENNEKMSKSKGNVVNPDDIIDSHGADTLRLYEMFMGPLDASIAWSTTGLDGARRFLDRVWRLLVDENTEEKSSKIVNGEGSPELKRAYHQTVKKVTEDFEELRFNVGISQLMVYVNEAYKQEELPLDQAEGFVKLLSPVAPHLAEELWSKLGHEGTIAYEPWPTYDEAFLVEDEVEIVVQHNGKVRAKVVVAKDATKEQMEEAALANERVKESIDGKTVRKVIVVPGKLVNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein: ESXH_MYCS2
Sequence: MSQIMYNYPAMLAHAAEMNTYSGALHAVGADIAAEQHALASAWQGDTGMTYQAWQAQWNQAMEELVRAYRAMATTHEQNTMAMSARDQAEGAKWG
What are the official names of this protein?
ESAT-6-like protein EsxH.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the ESX-3 / type VII secretion system (T7SS).
Protein: PRM1_PICST
Sequence: MPYLNFAERISQVYLNKYTLALVLVTIKVYLFQKTLVAAVRNIPDFSDCSVDELPTKVSVMIRNMVENNLNSFTYSTLALLHVAAKSILNLIWFAVEMLLGTYTCLFKAAIVGTSDFAADTSEMVVKGLNTTIVEITHDIQSGLDGLSSILNKVVSTASKVADFFTGNNNSDSPDQYQKSISLSLGKLTNLSIPSSVLGEINKIRIDPDFSSVENSTKKLIEEPFTSLTNQWNQNETLSLGGVKFPLLQPLSVCDIGSKSIQELSHNLSTSVEMAAKIVIIILAICAVLVMVPLIYDEWRKWNREERIIGNLVNQNTHYYFDLREAFSNLLHPYLRFLPKSWLSTYVFSNYSISFLLVGLLGLFVVFLQYIILRILIKKAKGTDIDTSQMTKELSNMTSVYLSQIDSYFQKQEDNINDKLFGSVKSTSSKINSTLHEFMSTLNDTVNSIFSNTPFSGPVNTIVYCTIGRKIDKVESGLTWINDNLSVKIPNINKKQLSDNLKSVISESDSSAGSVFAKGVQKTIAMYKSNLFLEFVISISLVGVWVMQLLIGVIIAVTKSHLKRRRLGSLTSSLDKTRISSPKELTKEEKLQYGYGFSVTNPYEVQRYSSKLSGTKIYNT
What is the function of this protein?
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
What are the official names of this protein?
Plasma membrane fusion protein PRM1.
What is the protein family that this protein belongs to?
Belongs to the PRM1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y290_MYCTA
Sequence: MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRAVGGSWADVLDGKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRRAAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASHGAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQERLFTGIDALAGRRSHVAVEDGAPMGPDEYAAKVEEERAAIAEGAEEHPFFQLVYNERCAPAAEWFGERGWTAVATLLNDYLEAVGRPVPGPESEAGPMFARNTLVSAARV
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MRA_0290.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: PLPP6_HUMAN
Sequence: MPSPRRSMEGRPLGVSASSSSSSPGSPAHGGGGGGSRFEFQSLLSSRATAVDPTCARLRASESPVHRRGSFPLAAAGPSQSPAPPLPEEDRMDLNPSFLGIALRSLLAIDLWLSKKLGVCAGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPHNAPVLFLLWSQR
What is the function of this protein?
Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354).  Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778).  May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354).  May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354).  Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839).  May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354).
What are the official names of this protein?
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6, Lipid phosphatase-related protein-B, LPRP-B, PA-PSP, Phosphatidic acid phosphatase type 2 domain-containing protein 2, PPAP2 domain-containing protein 2, Phospholipid phosphatase 6, Presqualene diphosphate phosphatase, Type 1 polyisoprenoid diphosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Nucleus inner membrane.
Protein: RL11_RHOBA
Sequence: MAKQVTGQAKFQVPGGQATPAPPVGTSLGKYGVNLGQFVQQFNDRTKEYNGTPIPVIVTVYNDRSFDFITKSPPAASMLMQSAGIAKGSGVPNKDKVATVTRAQCEEIAQKKMEDLNARDIDQATRMIEGTARSMGIIVDG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: PRPC_FUSSL
Sequence: MALNLTTSRRALGSLKPLTRAAFVGARGYATAEPDLKATLREAIPAKRELLKKVKAHANKTIGEVKVENTLGGMRGLKAMVWEGSVLDANEGIRFHGRTIKDCQKELPKGKTGTEMLPEAMFWLLLTGQVPSTNQIRVFSRELAEKAQIPEFVAKMLDNFPKDLHPMTQFAMAVSALNYESKFAKAYEQGLNKADYWEPTFDDCISLLAKLPTIAAKIYQNSYRGGGALPAEVDLEQDWSYNFAAMLGKGGKENENFQDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWILQMKEAIPAKYTEQDVNDYLWSTLNSGRVVPGYGHAVLRKPDPRFEALMDYAAARPEIAQDPVFQLVQKNSQIAPEVLKKHGKTKNPYPNVDSSSGVLFHHYGFHETLYYTATFGVSRGLGPLAQLVWDRALGLPIERPKSINLEGILKQVEGQ
What is the function of this protein?
Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate.  Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism.  Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate.
What are the official names of this protein?
2-methylcitrate synthase, mitochondrial, Methylcitrate synthase, (2S,3S)-2-methylcitrate synthase, Citrate synthase 2.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: HISZ_LEPIN
Sequence: MNQNLPEPNQKKWIPDGFHFLGPEDSKYRRTLLETISGVLKKKGYSEVFLPAFDYSSTFIQTVSAPDSSSLFRIRDLSGNEISPSIDLTVQAVKGMAGFSHQRENQNIFYIGRVFRESTKGSVARKEILQIGAESIGVSGKENTFKILEELDEIISLLPLENKLTLVLGNVNLFQSIVQEFELKQNEIEILSKLLYQKNVNEIQKIFGEKKNHTDLIRLLSSLVLNFDLNSLKNSLNINSLSKNLQKSLSSILEETYWIFNSWESKKRRIDLCIDFSLLRDLNYYTGFVFQGYLQDSPDPVLTGGTYDHLYEMFSGVQKNASGYALMVNTLESSLKTPLFNLSS
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATH1_YEAST
Sequence: MKRIRSLWFNAEASYSNLNNSPSLRNKNSTGNNSRSKNYRSFSRFDLINSILLLMMLFLLAIFVTALYLTKSSRLTYSHASRAALFNPLGVISPSLGNHTLNYDPEARESSKKLYELLSDFNTAYYDDENMILGSNLFSKNTYSRQPYVANGYIGSRIPNIGFGYALDTLNFYTDAPGALNNGWPLRNHRFAGAFVSDFYCLQPKLNSTNFPELDDVGYSTVISSIPQWTNLQFSLVNDSKWFNPQNVTLDDVTNYSQNLSMKDGIVTTELDWLNSQIHVKSEIWAHRHIHPLGVVSLEISLNTDHLPSDFDSLDVNIWDILDFNTSHRTVLHSTGTDEKNNAVFMIVQPDNVPSSNCAIYSTCTVKYENSTNPINSSESFEEKDVSSNIYNVILTEDQPKIIVHKYVGIMSTEFNKNKEQQDNTNIGLAKMIALNSKGNYEKLLSSHKRAWYDLYNDAFIEIPSDSLLEMTARSSLFHLLANTRDYNVSSDRGLPVGVSGLSSDSYGGMVFWDADIWMEPALLPFFPNVAQNMNNYRNATHSQAKLNAEKYGYPGAIYPWTSGKYANCTSTGPCVDYEYHINVDVAMASFSIYLNGHEGIDDEYLRYTTWPIIKNAAQFFTAYVKYNSSLGLYETYNLTDPDEFANHINNGAFTNAGIKTLLKWATDIGNHLGEVVDPKWSEISKDIYIPRSSSNITLEYSGMNSSVEIKQADVTLMVYPLGYINDESILNNAIKDLYYYSERQSASGPAMTYPVFVAAAAGLLNHGSSSQSYLYKSVLPYLRAPFAQFSEQSDDNFLTNGLTQPAFPFLTANGGFLQSILFGLTGIRYSYEVDPDTKKINRLLRFNPIELPLLPGGIAIRNFKYMNQVLDIIIDDHNGTIVHKSGDVPIHIKIPNRSLIHDQDINFYNGSENERKPNLERRDVDRVGDPMRMDRYGTYYLLKPKQELTVQLFKPGLNARNNIAENKQITNLTAGVPGDVAFSALDGNNYTHWQPLDKIHRAKLLIDLGEYNEKEITKGMILWGQRPAKNISISILPHSEKVENLFANVTEIMQNSGNDQLLNETIGQLLDNAGIPVENVIDFDGIEQEDDESLDDVQALLHWKKEDLAKLIEQIPRLNFLKRKFVKILDNVPVSPSEPYYEASRNQSLIEILPSNRTTFTIDYDKLQVGDKGNTDWRKTRYIVVAVQGVYDDYDDDNKGATIKEIVLND
What is the function of this protein?
Periplasmic acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source (PubMed:7502577, PubMed:8647289, PubMed:19703229, PubMed:8764988).  Growth on trehalose is strictly respiratory (By similarity).
What are the official names of this protein?
Periplasmic acid trehalase ATH1, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 65 family.
What are the subcellular locations of this protein?
Membrane; Single- pass type II membrane protein. Vacuole lumen. Periplasm. Note=May exist in the periplasm either as a membrane-bound or as a free protein (By similarity). Vacuolar localization is dependent on the multivesicular body (MVB) sorting pathway (PubMed:17475771). Vacuolar localization appears to be associated with its degradation (PubMed:19703229).
Protein: RL19_YERPG
Sequence: MSNIIKQIEQEQMKQDVPAFRPGDSVEVKVWVVEGSKKRLQAFEGVVIAIRNRGLHSAFTVRKISNGEGVERVFQTHSPVIDSITVKRRGAVRQAKLYYLRERTGKSARIKERLG
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: GRPE_BURCH
Sequence: MENTQENPTTPSAEDIGSEKQAAQGAAPAAEAADAALAEAQAKVAELQESFLRAKAETENVRRRAQDDVSKAHKFAIESFAEHLLPVLDSLEAAVNDTSGDIAKVREGVELTLRQLTSALEKGRVVAINPIGEKFDPHQHQAISMVPAEQEPNTVVSVLQKGYTIADRVLRPALVTVAQPK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSID_ECO57
Sequence: MRLFNWRRQAVLNAMPLVKPDQVRTPWHEFWRRFRRQHMAMTAALFVILLIVVAIFARWIAPYDAENYFDYDNLNNGPSLQHWFGVDSLGRDIFSRVLVGAQISLAAGVFAVFIGAAIGTLLGLLAGYYEGWWDRLIMRICDVLFAFPGILLAIAVVAVLGSGIANVIIAVAIFSIPAFARLVRGNTLVLKQQTFIESARSIGASDMTILLRHILPGTVSSIVVFFTMRIGTSIISAASLSFLGLGAQPPTPEWGAMLNEARADMVIAPHVAVFPALAIFLTVLAFNLLGDGLRDALDPKIKG
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Glutathione transport system permease protein GsiD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAV2_MICMU
Sequence: MGLETEKADVQLFLDDDSYSHHGDVDFADPEKFADSDHDRDPHRLNSHLKVGFEDVIAEPMTTHSCDKVWICSHALFEISKYVMYKFLTVFLAIPLAFVAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDVIIAPLCTSVGRSFSSISLQLSHD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Caveolin-2 may function as an accessory protein in conjunction with caveolin-1 (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: MSBA_BURPS
Sequence: MSVKPTLSKPIGGQDASSPAVVMRRLWPYVKPLVWVLVAGVLAMAAVAATEAGIPALLKPLLDHGFGSKGDMTTKLYVPAAVVGLALARAIAQYASGYLLQYVSNRILLDLRIQMFERMIHTGVSFFQRETASTVINAVVFEVNQVLSVLMGVTITLVRDSLTVVFLLGYLFYLNWRLTLIVAILLPCIGWLVGKINRRLRRLNREHQTLTNQLAYIVEETVGGYKVVKVHNGEPYEIGRFNELSRKLRGYSMRMTVSGGLAQPLTQFLASIALAVVLTIAVVQSANDQTTVGGFVAFVTAMLLIISPLKHLMDVNQPLQRGMTAAELIFGLIDEPREPEGGGKPLARASGAIEFSHVSFSYGMSRDGRQTLDDVSFTVAPGEMVALAGPSGSGKTTLVNLLPRFFDPSSGSVRVDGVALPEYSLRDLRNQIAMVSQDVVLFNDTIAANVAYGQAPERDRVEAALRAANLWETVTAMPDGIDTLVGDNGMRLSGGQRQRLAIARAIYKDAPILILDEATSALDSESERHVQAALETLMKGRTTLVIAHRLSTIERADRILVLEGGKIVESGSHRELLEQGGLYAHLHRIQFQQDAG
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PROB_SHEWM
Sequence: MNLSEIGYRRVVVKLGTSVLTSGSKQLDKAHMVELARQMSALMKAGVEVVLCTSGAIAAGREHLGYPKLADTVANKQLLAAVGQSQLILAWSQLFSIYGLHVGQLLLTQADLHDRERYLNARDSLNALLNNGIIPIINENDAVATNEIKVGDNDNLSARAALLCHADLLILLTDQQGLFDSDPRSNPDAKLIKQVVNIDDSLRQLAGGAVSGLGTGGMATKLEAADIARRAGIEVVIASGHRRQVILNAVCKEDVGTHFTALENPLESRKQWILAGQAAKGKLVLDVGAIKAVTEKGRSLLSKGVVSVIGEFDRGTTLQLIDSDGRECARGISRYSAGDLNKIVGKHSDEIESLLGYDYGDAVVHRNDMVVL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADCY9_MOUSE
Sequence: MASSPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNTHPKHCKYSISSSCSSSGDSGGLPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSMNLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAVHMKSKVIVMVVPALCFLVVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVWTPLSGRVDSSNHTLTATPADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVLFETFGYHFRNEDCYPSPGPGALHWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGRVIERLGQSVVADQLKGLKTYLISGQRAKESHCSCAEALLSGFEVIDDSRESSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGTVQNGCQDEPKTSTKASGGPNSKTQNGLLSPPAEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITCFLKYGATATPPPPAALAVFGADLLLEVLSLIVSIRMVFFLEDVMTCTKWLLEWIAGWLPRHCIGAILVSLPALAVYSHITSEFETNIHVTMFTGSAVLVAVVHYCNFCQLSSWMRSSLATIVGAGLLLLLHISLCQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGLNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDNGVVPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYSDKASLGSDDSTQAKEARLSSKRSWREPVKAEERFPFGKAIEKDSCEDIGVEEASELSKLNVSKSV
What is the function of this protein?
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors.  Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and by beta-adrenergic receptors.
What are the official names of this protein?
Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, AC9, Adenylyl cyclase type 10, ACTP10.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TIM22_CANAL
Sequence: MSLWGVYTGPQPPKKPLQEMTQEEQAEEGARQMIGFMNSCPGKTVMAGVSGFALGGFFGLFMASMAYDTPIGTDAVKHISELPFKQQMKLQFTDMAKRSYSSAKNFGYIGMVYSGVECTIESLRAKHDIYNGVSAGCITGAGLAIRAGPQAALVGCAGFAAFSLAIDMYLNSDAAPPPKNDYDI
What is the function of this protein?
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel.  Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM22.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COAG_TACGI
Sequence: DDTNAPLCLCDEPGILGRKEFVSDATKTIIEKAVEEVAKEGGVSGRGFSLFSHHPVFRECGKYECRTVRPEHSRCYNFPPFIHFKSECPVSTRDCEPVFGYTAAGEFRVIVQAPRAGFRQCVWQHKCRYGSNNCGFNGRCTQQRSVVRLVTFNLEKNGFLCETFRTCCGCPCRSF
What is the function of this protein?
Coagulogen is a gel-forming protein of hemolymph; it hinders the spread of invaders by immobilizing them.
What are the official names of this protein?
Coagulogen.
What is the protein family that this protein belongs to?
Belongs to the coagulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAU2_YEAST
Sequence: MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYSFQAAHPTETYPIEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSSRLKPAISSALSKDGIYTIAN
What are the official names of this protein?
Seripauperin-2.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family. Seripauperin subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NHAP2_SHEB2
Sequence: MDANSINSFFLIGALLTAVSVLLSPMSSRLGIPILLIFLAVGILAGEDGPGGILFDDYSTAYLVSNLALAIILLDGGMRTRVASFRVALWPALSLATFGVAITTSITGMMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGSNDPMAVFLTVTLIAILANVDTEMSFSFMFISFIKQFGLGICLGLGGGWMLWKLVNLSKLADGLYSILVLSGGLIIYAASNKLGGSGILSIYLVGLFLGNKPTRGRHAILNVLDGMTWVSQIGMFLVLGLLLTPSDLVDILIPGFALAFGMILFARPVAVWISLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLVQGASLTTAARLAKVELPPKPLPVSRSGVEIYPSSEWEVFVYRLSESKWCIGEPLKRLAMPDGTRIAAVFRNDTLLHPSGSTRLEAGDILCVLGQEKSLEALSNLFSQAPENKEVQRFFGDFFIETDVKLADLAPIYGLSLDNLADDMTVADLVVSQLGANPVLGDQFQWQSLHWVVAGLYEGKVTNVGIRLPTEHSL
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.