PharMolix/UniProtQA huggingface dataset:
Protein: CASP_PONAB
Sequence: MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRVTEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPTAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSMSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ
What is the function of this protein?
May be involved in intra-Golgi retrograde transport.
What are the official names of this protein?
Protein CASP.
What is the protein family that this protein belongs to?
Belongs to the CASP family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type IV membrane protein.
Protein: YPF14_PLAF7
Sequence: MDSDKYKKFYVYNHGFTKQPFYERNLNDKGIHLKELKRLERVDEPRLYNNVDKIPNKKEIIYNNIKSNNIQVRVNQNNNEEKKKEEANYTCVNNKYVTLKNKVHVNKYVNNSNINKIKIVPIIKCSNYKIKNNPISHLKSNYENKFVKLSNFSNIKNGCSHKDNVINETMDQHKSEQLNNDNIKKLLYDYCIFREDTIKTKTNISYNKMNSFKDNEENINYMDNNNIKSNSSSYCSYSNKINQNNVNHTHLKTEFLNEKNSHTQNEQSIPLLDGLQNNHNSATKFHNNIYDNNNSLVNYKSDKGIDLHNKMMKIETDKNGIITLEKKKHDEKYYNNIFLNPLNDNSNNVVITTCDNKESYRNSTSDMINKIFEKMMNEKKNILKMKNFNDVIKKKITMAKEKILNSNSTINMKKVSFYNSKDEDLFNEKENSYKYGVKRENQEDINVIKNNMKRNNINIDNNDNINIIKNDSVSKNIHINNKKKRDDDFPFNNSAGLLLDFDLCKRKVLEILKNVQSSKKKNKILTNHNHSSDNQNCHSSDNQNCHSSDNQNCHSSDNQNCHSSDNQNCDSNACNKKDEEKKRKKKKIKKKNKMKNKSNNKSKNKRETKSKKISNNNNNDNMNNQCDNMGDQRINNENMDKQNVNIQNEGNGFNNNKNNNDLLNVYISPNMINHSLSSTCEKKNKEDNKMNDNKFLNSSSKMKIPEISTNNSNEKIVNVSNDEMLVYHNLTVLNVKEQGGVTEESSCIKRTYFVDQFYDSYNMRNEKITDDNMQVEDIYNVKENIKRTLKGDGHDDVKTNMLSEDNSYASGLWGNEINFISNNENCLNSYDISCDEKYIPNEEEQDEELCSNNILVKDIEEKKMCGKLFFEEICVFRINEKNEHGHENLRKNNHNDDTHKMYSSYENIQNINKQSTNPFCKKDEMEKSQGTNLFYDNYINSVDITKLELNKNCYQHINYEVQNLIKKENSYAAEMNVGLVFRKYIPILINLSCNYLLIKKNEKNVITCISYTNIIDVKIVKKSKKNKERFLFKIVYVFKKKEQKTEKNVTLLFRANLMEIFEKIKGRVDYCIIPNEDDKNIQLQDKKKKKGKKKKELQEEKMKKKKKTQEYVDIETVYEYVIEKYKRVHVLYLGRLLQIVEKLFKKYILKYSFHKLRIFYEYKIEMEKLKKNYIHCIYDISDKLEFLIKKKMQHYFNHIIINSYESSFINYQIKTNDMLYNLLLKEKSAYQNHLGKNYILILYKVLLSMYKKKMAIYFRSFVYNNIKVSKKKNAFAYTLTRVNSILVLYERRIKSFIFSKLKFNYDNVSYFCFTMYKIYLRRILFGYLRIRDNRINIKNVIEKNVYRLVKLISKISDNHKYNAFLKLQKYVYEQNEKKNKMICDNLIYANNELCNNLDKIAIEKGINQIDCLIKFKRKECLMKYFYTLKGPQINTERFYYCIRYCSIFSFVLNKIIQKKVQHIFFQFVLKTLQRNNKNRLTHAIKLLQVLVQKKEKKSVIDVLQLYDKYPYIFQYKDLTKIEVFVICVQNFVTLYNRKLLLNFLLKLHYLKYQEQFMKTYNGIGSIYKFVHVLDKKLMNTIRESFRVILQNDKFLREKMNMKMEQMDMKMEKIDVNMDQMDVKMEQMDVKMEQMDVKMKRMNKKKSKQIHVNYNNKAYSSSSPSPMLRYNKYKDMSSNSASLIKKYPFLIYNSEISPDCTTMADDKLSLPSNESVTHIFSYAYEDMDKIKKKIYDFNNKMSNVDL
What are the official names of this protein?
Uncharacterized protein PF3D7_0207100.
Protein: SNAA2_ARATH
Sequence: MGDHLVRAEEFEKKAEKKLNGWGIFGSKYEDAADLLEKAANSYKLAKSWDQAGKAYLKLADCHLKSDSKHDAANAYAEAAKCYKKVDTNEAASCLERAVNIFCEIGRLNMAARYYKEIAEYYESDQKFEQAIAYFEKAAEFFQNEEVTTSANQCNLKVAQYAAQLEQYEKAIKIYEDIARHSLNNNLLKYGVKGHLLTAGMCHLCKADVVSITNALEKYQDLDPTFTGTRECKFLADLASAIDEEDIAKFTDVVKEFDSMTPLDSWKTTMLLRVKEKLKAKELEEDDLT
What is the function of this protein?
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.  Binds to SNARE complex and then recruits NSF to disassemble it (By similarity).
What are the official names of this protein?
Alpha-soluble NSF attachment protein 2, Alpha-SNAP2, N-ethylmaleimide-sensitive factor attachment protein alpha 2.
What is the protein family that this protein belongs to?
Belongs to the SNAP family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: QUEA_GEODF
Sequence: MQLKDFNYHLPPELIAQEPAHRRESARLMTLDRKSGEIGEGVVADIAEYFVAGDLLVINDTKVIPARLLGRKETGGKAEVFLVRRRDEAGQVWQCLIKCSKSPAPGSLILLSEGVTARIVERSEHDTWIVSFSPEEGFLDRLEMIGSMPLPPYIHRPANVIDGERYQTVFARERGAVAAPTAGLHFTESLLQKIRARGVDILPLTLHVGLGTFMPVRVKDLSEHRMHREYYRIPETTAKAVTDRKKAGKRVIALGTTTTRALEHAAAEDGSLDAKEGEADIFIVPGYAFKTVDALITNFHLPESTLLMLVSAFAGRDRLFNAYAEAVRRKFRFFSYGDAMFIY
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFUA_SHIB3
Sequence: MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEATDTALKFDLLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVADDAPLMERVEYMLQSQINPQLAGHGGRVSLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEKQLLNEFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: DNAK1_ALIF1
Sequence: MGKIIGIDLGTTNSCVAVLDGDTPRILENAEGERTTASVIAYTDGETLVGQPAKRQAITNPQNTLFAIKRLIGRRFEDEEVQRDIEIMPYKIIKADNGDAWVEAKGQKMAAPQVSAEILKKMKKTAEDFLGEEVTGAVVTVPAYFNDAQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKKGGDRTIAVYDLGGGTFDISIIEIDNVDGEQTFEVLATNGDTHLGGEDFDNRLINFLVDEFKKEQGFDLKNDPLAMQRVKEAAEKAKIELSSAQQTDVNLPYVTADATGPKHMNIKVTRAKLESLVEDLVVRTLEPLKVALADADLTIDGITDVILVGGQTRMPMVQAKVAEFFGKEARRDVNPDEAVAMGAAVQGGVLAGDVKDVLLLDVTPLSFGIETMGGVMTKLIEKNTTIPTKADQTFSTAEDNQSAVTIHVLQGERKQASYNKSLGQFNLEGIQAAPRGMPQIEVTFDLDADGILNVSAKDKSTGKEQKITIQASGGLTDEEIEAMVQEAEANKDADKKFEELVTARNQADQMIHGTKKQIEEAGDDLPTDEKEKIEAAITALEGVKSGDDKEAIDAKTQELMQAAQKLMEIAQQKAQAQQGAQAGEQPKQEDDVVDAEFEEVK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK 1, HSP70 1, Heat shock 70 kDa protein 1, Heat shock protein 70 1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TM10B_HUMAN
Sequence: MDWKLEGSTQKVESPVLQGQEGILEETGEDGLPEGFQLLQIDAEGECQEGEILATGSTAWCSKNVQRKQRHWEKIVAAKKSKRKQEKERRKANRAENPGICPQHSKRFLRALTKDKLLEAKHSGPRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMNDGFSSYLLDITEEDCFSLFPLETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNQNGKNYHSEILAINQVFDILSTYLETHNWPEALKKGVSSGKGYILRNSVE
What is the function of this protein?
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678).  Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).
What are the official names of this protein?
tRNA methyltransferase 10 homolog B, RNA (guanine-9-)-methyltransferase domain-containing protein 3, tRNA (guanine(9)-N(1))-methyltransferase TRMT10B.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
Protein: HSCA_ACIF5
Sequence: MALMQIAEPGTAADPHQRRLAIGIDLGTTHSLVASVLSAVPTVMRDHDGKYLLPSVVRYLGGGGIHVGYPAVAAAGQDPHNTIASAKRLMGRGHGDVQTLAGHLPYDLVPGEGMVRLRTVAGEKSPVEVSAEILRVLKERAVETLGGEPEGAVITVPAYFDEAQRQATKDAARLAGLNVLRLLAEPTAAAVAYGLDKGSEGIFAIYDLGGGTFDISILRLQAGVFEVLATAGDSALGGDDMDHALAEWLMQEEGGDASDPLWRRQVLQQARTAKEALSAVAETMIVLTPSGRAAREIKLSRGRLESLIQPVIQRSLPACRRALRDAGLKLDEIEGVVLVGGATRVPAVRAMVEEFFRQKPLTDIDPDQVVAIGAAIQADALVGNQREDLLLMDVLPLSLGLETMGGLVEKIIPRNTPIPVARAQEFTTFKDGQTAMSIHVVQGERDLVQDCRSLARFSLRGIPPMVAGAARIRVTFQVDADGLLAVRAEETSTGVRSEVVVKPSYGLNDEEIARMLQDSFIHGAEDVVRRRLSEAKVEGERVREALRTALAADADLLDPAEREALDKAGTALTNALSGDDAGVITAAAEAVETAAEPLVQRRMDSALRRAITGRSIDELGD
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PFD5_YEAST
Sequence: MSSQKIDLTKLNPEQLNAVKQQFDQELQHFTQSLQALTMAKGKFTECIDDIKTVSQAGNEGQKLLVPASASLYIPGKIVDNKKFMVDIGTGYYVEKSAEAAIAFYQKKVDKLNKESVQIQDIIKEKTQYSLSIEAQIRQAAIRQHEAMSKQQQQQQKKESSTA
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
What are the official names of this protein?
Prefoldin subunit 5, Genes involved in microtubule biogenesis protein 5, Gim complex subunit 5, GimC subunit 5.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit alpha family.
Protein: DPPA2_MOUSE
Sequence: MSYFGLETFNENQSEENLDEESVILTLVPFKEEEEPNTDYATQSNVSSSTLDHTPPARSLVRHAGIKHPTRTIPSTCPPPSLPPIRDVSRNTLREWCRYHNLSTDGKKVEVYLRLRRHSYSKQECYIPNTSREARMKQGPKKSKIVFRGIGPPSGCQRKKEESGVLEILTSPKESTFAAWARIAMRAAQSMSKNRCPLPSNVEAFLPQATGSRWCVVHGRQLPADKKGWVRLQFLAGQTWVPDTPQRMNFLFLLPACIIPEPGVEDNLLCPECVHSNKKILRNFKIRSRAKKNALPPNMPP
What is the function of this protein?
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.
What are the official names of this protein?
Developmental pluripotency-associated protein 2, Embryonic stem cell-associated transcript 15-2 protein, ECAT15-2, Pluripotent embryonic stem cell-related gene 1 protein.
Protein: DEOD_HAEIE
Sequence: MTPHINAPEGAFADVVLMPGDPLRAKYIAETFLQDVVEVTNVRNMLGFTGTYKGRKISIMGHGMGIPSCSIYAKELITEYGVKKIIRVGSCGSVRMDVKVRDVIIGLGACTDSKVNRIRFKDNDFAAIADFDMAQAAVQAAKAKGKAVRVGNLFSADLFYTPDVEMFDVMEKYGILGVEMEAAGIYGVAAEYSAKALTICTVSDHIRTHEQTTAEERQLTFNDMIEIALDSVLIGDAQ
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: 2ABD_XENTR
Sequence: MAGVGGGNDFQWCFSQVKGAIDEDVAEADIISTVEFNCSGDLLATGDKGGRVVIFQREQENKSRPHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAHFLLSTNDKTIKLWKISERDKRVEGYNLKDDDGRLRDPFRITSLRVPILKPMDLMVEASPRRIFANAHTYHINSISVNSDHETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPHHCNVFVYSSSKGTIRLCDMRDSALCDRHSKFFEEPEDPSSRSFFSEIISSISDVKFSNSGRYMMTRDYLSVKVWDLNMESRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSAIMTGSYNNFFRMFDRNTRRDITLEASRESSKPRAILKPRKVCTGGKRKKDEINVDSLDFNKKILHTAWHPTDNIIAVAATNNLYIFQDKVN
What is the function of this protein?
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit.  The activity of PP2A complexes containing ppp2r2d (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis.  During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ensa and arpp19 inhibitors.  PP2A complexes containing ppp2r2d (PR55-delta) also regulate the activity of TGF-beta/Activin/Nodal signaling by restricting receptor activity.  Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform, PP2A subunit B isoform B55-delta, PP2A subunit B isoform PR55-delta, PP2A subunit B isoform R2-delta, PP2A subunit B isoform delta.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUH_BOVIN
Sequence: MAPVVTGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPPNESNTNSEGSYTNVSTNSTSVTSSTATVVS
What is the function of this protein?
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations.  Acts as a transcriptional repressor when it is not associated with Notch proteins.  When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes.  Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively.  Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.  Binds specifically to methylated DNA.  Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen).  Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).
What are the official names of this protein?
Recombining binding protein suppressor of hairless, J kappa-recombination signal-binding protein, RBP-J kappa.
What is the protein family that this protein belongs to?
Belongs to the Su(H) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA1, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
Protein: YIDC_MYCBO
Sequence: MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSVMFLVFTLRALLYKPFVRQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHGFNPILGCLPMLAQIPVFLGLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVGHFLDANLFGAPIGAYMTQRSGLDAFVDFSRPALIAVGVPVMILAGIATYFNSRASIARQSAEAAANPQTAMMNKLALYVFPLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGMIEKEEEAKKQEAVRRRAANAPAPGAKPKRSPKTAPATNAAAPTEAGDTDDGAESDASTERPADTSNPARRNSGPSARTPRPGVRPKKRKR
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEU1_ECOK1
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: MNMA_ENT38
Sequence: MSASPKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLEEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADFIATGHYVRRADVDGKSQLLRGLDGNKDQSYFLYTLGHDQIVQSLFPVGELEKPEVRKIAENLDLITAKKKDSTGICFIGERKFREFLGRYLPAQPGKIITVDGDDVGEHQGLMYHTLGQRKGLGIGGTKEGSEEPWYVVDKDVENNILVVAQGHEHPRLMSVGLIAQQLHWVDREPFTGTLRCTVKTRYRQTDIPCTVTALDEERVEVRFDEPVSAVTPGQSAVFYSGEICLGGGIIEQRLPLAAV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTYB_ASPRU
Sequence: MIATEYPRPPLAGIDWNHLGFEPVEVNGHIESRFSPSTKTWSTPTFIPDPYIRIHGLTPALNYGQQIFEGLKAFRTPSGSITVFRPDQNAHRFARSARAVSIPPIPTDIFLEAVHLAVGMNSEFVPPVGTGAALYIRPLAFASSATVGLALASEFLFCVYVLPVAPLHKHSGENDKDRKKRGVRALVVEDFDRAAPRGTGDVKVGGNYGPALGRIDAARQEGYGLTLHLDSQSRSLVDEFSTSGFIGVRKENDDELKLVVSDSQQIVASVTIDSICEIARGFGWAVEKRSIAFTEVSEFVEVYAAGTAAMLVPVQSVERRSTGEFIQYSVDYAEPTSVFAQLYKALSGVQQGLVPDQWGWTQEVLRPKQLASQDTEADT
What is the function of this protein?
Transaminase; part of the gene cluster that mediates the de novo generation of L-homotyrosine from acetyl-CoA and 4-hydroxyphenyl-pyruvate (PubMed:22998630).  L-homotyrosine is a building block of echinocandin B, a fungal lipidated cyclic hexapeptide that acts as an antifungal agent (PubMed:22998630).  L-homotyrosine 4-hydroxyphenyl-pyruvate first undergoes an aldol-type condensation by htyA with the C-2 of acetyl-CoA followed by the release of CoA to form 2-(4-hydroxybenzyl)-malate (PubMed:22998630).  This is followed by isomerization of 2-(4-hydroxy-benzyl)-malate to 3-(4-hydroxybenzyl)-malate by htyD (PubMed:22998630).  Thereafter, 3-(4-hydroxybenzyl)-malate undergoes decarboxylation and oxidation to form 2-oxo-4-(4-hydroxybenzyl)butanoic acid, coupled to reduction of NAD(+) to NADH by htyC (PubMed:22998630).  The product then undergoes transamination catalyzed by htyB to form L-homotyrosine (PubMed:22998630).
What are the official names of this protein?
Transaminase htyB, L-homotyrosine biosynthetic cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: RECA_THEP1
Sequence: MSDEKQKKSVLEKALKRIEENFGKGSIMILGDETQVQPVEVIPTGSLAIDIATGVGGYPRGRIVEIFGQESSGKTTLALHAIAEAQKMGGVAAFIDAEHALDPVYAKNLGVDLKSLLISQPDHGEQALEIVDELVRSGVVDLIVVDSVAALVPRAEIEGAMGDMQVGLQARLMSQALRKIAGSVNKSKAVVIFTNQIRMKIGVMFGSPETTTGGLALKFYATMRMEVRRGEPIKEGKDVIGNVISVKIVKNKVAPPFKTAQTYIIYGKGIDREYELFNIAVEESMVERKGSWYYYTTLKGEEVSLGQGSSNAVQFLKDNPEIAGEIERRIREKYGLLSVEKEEQKKEEKSSDEEAS
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHI2_HORVU
Sequence: MRSLAVVVAVVATVAMAIGTARGSVSSIVSRAQFDRMLLHRNDGACQAKGFYTYDAFVAAAAAFPGFGTTGSADAQKREVAAFLAQTSHETTGGWATAPDGAFAWGYCFKQERGASSDYCTPSAQWPCAPGKRYYGRGPIQLSHNYNYGPAGRAIGVDLLANPDLVATDATVGFKTAIWFWMTAQPPKPSSHAVIAGQWSPSGADRAAGRVPGFGVITNIINGGIECGHGQDSRVADRIGFYKRYCDILGVGYGNNLDCYSQRPFA
What is the function of this protein?
Defense against chitin-containing fungal pathogens.
What are the official names of this protein?
26 kDa endochitinase 2, CHI-26.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class II subfamily.
Protein: AN32A_HUMAN
Sequence: MEMGRRIHLELRNRTPSDVKELVLDNSRSNEGKLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYDEDAQVVEDEEDEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEELGEEERGQKRKREPEDEGEDDD
What is the function of this protein?
(Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:32694517, PubMed:33045004, PubMed:33208942, PubMed:30666459).  Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942).  Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877).
What are the official names of this protein?
Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32, pp32, Leucine-rich acidic nuclear protein, LANP, Mapmodulin, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, Putative HLA-DR-associated protein I, PHAPI.
What is the protein family that this protein belongs to?
Belongs to the ANP32 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm.
Protein: RS18_BURM1
Sequence: MARPTGKKFDKRRQQQNPLFKRKKFCRFTAAGVEQIDYKDTETLKDFIGENGKITPARLTGTKAHYQRQLDTAIKRARFLALLPYTDQHKA
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RSMH_SALG2
Sequence: MMENFKHTTVLLDEAVNGLNIRPDGIYIDGTFGRGGHSRLILSQLGEEGRLLAIDRDPQAIAVAQTINDPRFSIIHGPFSALADYVAERELTGKIDGILLDLGVSSPQLDDAERGFSFMRDGPLDMRMDPTRGQSAAEWLQTAEEADIAWVLKTFGEERFAKRIARAIVERNREQPMTRTKELAEVVAAATPVKDKFKHPATRTFQAVRIWVNSELEEIEQALKSSLSVLAPGGRLSIISFHSLEDRIVKRFMREQSRGPQVPAGLPMTEAQLKKLGGRELRALGKLMPGEKEVAENPRARSSVLRIAERTNA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.