PharMolix/UniProtQA huggingface dataset:
Protein: Y2247_BURO0
Sequence: MIIVLSPAKSLDYETPAHVEAYTKPAFVDDASELIDGLRKLSPQDIAALMDISDPLARLNFQRYADWSSTFTPANAKQAVLAFNGDVYEGFDAKSLSSTDLDYAQQHVRVLSGLYGLLRPLDLLQPYRLEMGTRFANARGKDLYAFWGDRITRALNEQLETRSGAARVLVNCASTEYFKSVKPKLLAAPVITPVFEDWKGGRYKIISFHAKRARGLMARFVVENRITDPNALKAFSTEGYVFDAAASNDSTYVYRRRVGE
What are the official names of this protein?
UPF0246 protein Bcenmc03_2247.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: HUTG_COREF
Sequence: MENETFGTELPDTWVGRIDGDNPEHALWYTTVSPLPEPDEVEEGVVTLGFASDEGNLRNHGTAGAALGPDAIRGVLGLVAVHDARPRYDAGTIRVGGDLERGHDELSDAVETIARAGHLPIVLGGGHEAGFGSHRGIYRARGSSPAIINLDAHLDLRAAERPTNGTPFRQVRELVGEEFRYSVLGVSVPNNTDFLFNAAREFGTEVTTDDEINAMSPQEAADHALALVRDAEHIHLTVDIDVLSEALAPGTGSPAAVGVELGRIRAICTGLAATGRLTLVDVVEVNPRLDHNNQTARVAARLIHEIAEAHLKAT
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: ERPA_PSYCK
Sequence: MNQPANQFNPSSSQPVDPTVLNLTDSAAQKVRRLREEEGDSNLMLRVYVTGGGCSGFSYGFNFANELNEDDANFDNNDVTLVVDSLSYQYLQGSTVDYTEGLEGARFIVTNPNATTTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: TRPD_DESHY
Sequence: MTYAIHESLTLLSQKQDLPEELTFTVVQDLLSGELTPAQIGGLLLGLSLKGETPEEIAAFAQALRGAGLKIKAPAGTLDTCGTGGDRSGTFNISTTAAFVIAGAGVPVAKHGNRFASGRCGSADVLEQLGISLKATPESSERHLQHIGMTFLFAQVYHPAMAKVAAERRELGIRTIFNLLGPLLNPAGAPYQLLGVSSPSLLPKMAKALQILGSKRAVVAVGEDGLDEVTLTGATQAILIDGGEIQPFIIRPEEYGLNLCSLQDLQGGTPAENGQITLRILQGKKGPQRDIVLLNAGTALYAANKAAGIREGIALAAESLDSGKALSILEKLKASA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: Y5465_DICDI
Sequence: MDSPIFSNDIDSIKNNTYQAKSYQKYNNSNNYNNNNNNSFNNYSNGSNYGGYNNSGNNSNYNNNNNLYNNNNINNNNNNNNNNNINNNNNNINNNNNINNNNSNNNNNNNNNNSNSNNSINSNSYKVNTPTQNGKSSHSPPLINANANVVFPTFKSLDLSSDTVNSVGAANNGSSNSSPTINGISNSNTMNNNNNNNNNNNNNSNSSNNNNNGNNNNNNNYNSFVNITKNNNNTNSNNYNNSTNSNNNGYNNNNNNNSISNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSSSNSSSSSNNNNNNNNNNNNNNNSSSSSSNSNGNNNNNYHSYGYSNSKYNQQKSYNNAPHQLNSGGGQNSYYNKNNYNNGNGNIGNGNNSGSGNSSNSNGWSGGYQKQNGANRYQSQSQQQPQQQQQQQPQQPQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPQQQQQQQQDIGDSSRMNGGSRVPKAPGSDIGFNRGLNNSLNGQTDLNNSNYNSNSNNNNTNNNNTNNNLVNGKLQHYNYNNSSFKFNKNAQYNNGNNNGNNNNNNNNNNNNNNNNNNNSNNNSTNNNNINNSGNNNISNSVSSNSNGNVGSNPHRFQKNHFEKPFNSNSSTPSTPPNSTPSSSTTTSPSSSFNTYSNTFNNGSSNSFNNGSFNNSFNNGSSSNGSFNHGSFNNGSSISSFSGSFNNGSSGSGFNASFNGGSNSNSFNNGDNNNNNNNNNNNNHHNNDIDDSEPIIDQLDSTGEEEMDNLIGKLDLFSTKSESLFHTWKLNYSNRNNNNNNNSNNNNNNNNSSNNNSNSNNNNDNNNNDSFDGSNSDSQNIETDRTTTKVYITGKNFNNHNNNNNNNNNNNNHHYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNENNNGDVFSNGFSTWTPKSGSNSLNNSQNNLSNGQNSSNNSQNNLNNSQNSLNSSGNHHSNYHGHNNHHHYNNNNNNNNNNNNNNNNNNNNNNNGNGYVKSYYNNKYQQKSPQHQSSNSVVLIPPPGFSTIAPPPGFSTNNNNNNNNNNNNNNNKNNNSNNNNIIEVGKANYQTSTLNNSQDDSYQQEQEQQEQESQQQQQQQQQQQQQQQQQQQQQQQQQNYSSTPPNITPHLKGDGGLEKWFGNNIYSFGASQSLNNENTNPSYSYVPYNNNNNNNNNFNNINNDNNDNDIINNNHQQTNPSLQNDTPPIKMLSLEEIERW
What are the official names of this protein?
Uncharacterized protein DDB_G0283357.
Protein: CFBA_METTH
Sequence: MDSNSNQKPKIGVLLVGHGSRLPYGEEVINGIADIYRQEADHPVAVGFMNMSRPSIPEAINELAAMGVEKIIVTPVFLAHGVHTKHDIPHILGLDNGAEGHHHHEHEHEHEEFEFDGEIVYTEPLGADPRIAEIIRDRVKSAI
What is the function of this protein?
Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (PubMed:12686546).  Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (Potential).  Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (Potential).
What are the official names of this protein?
Sirohydrochlorin cobaltochelatase, CbiXS, Sirohydrochlorin nickelchelatase.
What is the protein family that this protein belongs to?
Belongs to the CbiX family. CbiXS subfamily.
Protein: TGT_CHLTB
Sequence: MALRFEILHQSKKSRARVGRIETAHGYIDTPAFVPVATNGALKGVLDHSNIPLMFCNTYHLIVHPGAEAIAAMGGLHQFIGRNAPIITDSGGFQIFSLAYGSVAEEIKSCGKKKGGNTIIKVNDDGVHFKSYRDGRKLFLSPEISVQAQKDLGADIILPLDELLPFHADPTYFHQSSQRTYVWEKRSLDYHLKNPGIQSMYGVIHGGTFPDQRKLGCKFVEDLPFDGSAIGGSLGKNLQDIVEVVGVTAANLSAERPRHLLGIGDLPSIWATVGFGIDSFDSSYPTKAARHGMILTSQGPLKINNQRYSSDLNPIEPGCSCLACSQGITRAYLRHLFKVHEPNAGIWASIHNMHHMQKVMREIREGILNDRI
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: MLE_BRAFL
Sequence: MAEIEQSMIDEMKDGFPLFDNKGDGKIDGAQLGDVLRSFGLNPSNAEVEKIAKANEGKRLSFDDYLAIHKQVLGQGEVGSYEDFFEGLKLFDKEGTGLISGAELRHVLATLGEKLTEAQVDELMAGGGGQEDAEGNVNYDTFAKYLMLG
What are the official names of this protein?
Myosin, essential light chain, Myosin light chain alkali.
Protein: LSPA_TRIV2
Sequence: MRFKNRLFWIAAFIAFFVDQLTKYWVVQTFSLGETLPILPGIFHFTYVTNTGAAFSLFSGKVEWLRWLSLGVSLLLIGLALLGPVLERWDQLGYGLILGGAMGNGIDRFALGYVVDFLDFRLINFAVFNMADSFISIGIVCLLLASLQKSPDSHHRSR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MET3_CANGA
Sequence: MPAPHGGVLQDLVARDASKRDSLLSESQQLSQWTLTARQICDIELILNGGFSPLTGFLAQEDYNGVVHNSRLSDGTLWTMPITLDVPEQFANSVKPNQRIALLQDGTIPVAILTVKDIYKPDKSVEAEKVFRGDPEHPAINYLFNTAGDYYIGGALDAIQLPQHYDYPGLRKTPAQLRLEFQSRQWDRVVAFQTRNPMHRAHRELTVRAARETNAKVLIHPVVGLTKPGDIDHHTRVRVYQEIIKRYPNGIAFLSLLPLAMRMGGDREAVWHAIIRKNYGASHFIVGRDHAGPGSNSKGVDFYGPYDAQELVESYKNELDIDVVPFRMVTYLPDEDRYAPIDEIDTSKTRTLNISGTELRKRLRDGGEIPEWFSYPEVVKILRESNPPRPKQGFALVFNDDIKVDRDQLSIALLSTFLQFGGGRHYKIYDHNDKPEFLELISDFVQAGSGLIIPSTWSASNKVNSANVYTIGHAKDADIKLASTEETIFHIVQKVVLFLEDNHFIQF
What is the function of this protein?
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.  Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH5_SCHPO
Sequence: MFYLIGLGLFDEKDITLRGLETVKKCQRIYLEAYTSILLVQKEKLEELYGKEVILADREMVESSSDEILKDADNCDVAMLVVGDPMGATTHADLVIRARELKIPVRMIHNASIMNAIGACGLQLYKFGQTVSLVFFENNYRPQSFYDHIKENVSLGLHTLVLLDIKVKEQSWENLARGRKVYEPPRYMSASLAAQQMLEVEEDRQENICTPDSLCVAVGRMGSDDQVIFAGTLQELAEHDIGPPLHSVVLVGRDVHDLELEFLRAYAVNLENFDRVAKTYLEK
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester.  The four successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine methyl ester synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBA_MICAE
Sequence: MTTTLQQRESASLWEQFCQWITSTNNRLYVGWFGVIMIPTLLTATTCFIIAFIAAPPVDIDGIREPVAGSLLYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVIFHFLLGVFCYLGRQWELSFRLGMRPWICVAYSAPVSAATAVFLIYPIGQGSFSDGMPLGISGTFNFMFVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTEIESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLGAWPVIGIWFTAMGVSTMAFNLNGFNFNQSILDSQGRVIGTWVDVLNRAGIGMEVMHERNAHNFPLDLASGEQAPVALTAPAING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PE2R2_RAT
Sequence: MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
What is the function of this protein?
Receptor for prostaglandin E2 (PGE2).  The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase.  The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle (By similarity).
What are the official names of this protein?
Prostaglandin E2 receptor EP2 subtype, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CDII2_BURP2
Sequence: MAIDLFCYLSIDRGAAESDLNKIRSNHSELFEGKFLISPVRDADFSLKEIAAEHGLVAESFFLVSLNDKNSADLIPIVSKILVDGFNGGAILILQDNEYRR
What is the function of this protein?
Expression of this cdiAIB locus in B. thailandensis confers protection against other bacteria carrying the locus; growth inhibition requires cellular contact.
What are the official names of this protein?
Immunity protein CdiI-2, Immunity protein CdiI-II.
Protein: VE6_HPV94
Sequence: MSMGAQEPRNIFLLCRNCGISFEDLRLCCVFCTKQLTVAELTAFALRELNLVWKAGVPYGACARCLLLQGIARRLKYWQYSYYVEGVEEETKESINTQQIRCYTCHKPLVKEEKDRHRNERRRLHKISGYWRGCCAYCWTRCTVRIPQ
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Sequesters tumor suppressor TP53 in the host cytoplasm and modulates its activity by interacting with host EP300 that results in the reduction of TP53 acetylation and activation.  In turn, apoptosis induced by DNA damage is inhibited.  E6 protects also host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: SYL_RIPO1
Sequence: MESQYNAAAIEQKWQQDWVKQGLDKTPENSNKPKFYALSMFPYPSGNLHMGHVRNYVITDVIARLKRLQGYRVLHPMGWDAFGLPAENAAIDRGIPPAEWTYKNMSQMKQQLQTLGLSIDWEREVATCAPEYYKWTQWLFLQLYQAGLAYQKEAAVNWDPIDQTVLANEQVDSEGYSWRSGAKVERKLLRQWFLKITDYAEQLLTDLDKLPGWPDRVKLMQENWIGKSVGAYLEFPIKGSEEKIAVFTTRPDTVYGVTYVVLAPEHPLTLKVTTPEQKAAVDAFIEEVSNESEIERTAEDKPKRGILTGGTAINPFNGQEIPILIADYVLYEYGTGAVMGVPAHDTRDFKFAKEKQLPIKVVIIPENSDNTNPPLTEAYTDPGIMVNSGIFDGIQSTEGKTAIIEYAEKEGYGKARIQYRLRDWLISRQRYWGCPIPVVHCPSCGTVAVPDADLPVKLPENVEFTGRDASPLAKLEDWINVPCPSCGEPAKRETDTMDTFIDSSWYYLRYTDANNNQEAFNLEKANDWMAIDQYVGGIEHAILHLLYSRFFTKALRDRGLVNIDEPFKRLLTQGMVQGLTYKNPQTGKYVPSENVIFQDDHYRDKETGEILSFFYEKMSKSKYNGVDPKQVLGKYGADTARMFILFKAPPEKDLEWDDADVEGQFRFLNRVWRLVANYLENKPKTVKKASELTKEDKDLRRAIHTAIKEISEDLEGDYQFNTAVSELMKLSNALTDAKCLESGVYQEGIETLLILLAPFAPHIAEELWHNLGYEKSIHLQSWPTVNPDALVVDEITLVIQIMGKTRGTIQVSATATKDELEKLARESEVGQRYLDGQDVKKVIVVPGKLVNFVIAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_PTYGA
Sequence: VGFKAGVKDYRLNYYTPDYQTKETDILAAFRMTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDLEAVPGEENQYIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEALYKSQAETGEIKGHYLNATAGTCEEMLKRAEFARELGAPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGERQVTLGFVDLLRDDYIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHXPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEVIREATK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUOK_CHESB
Sequence: MEVGIAHYLTVSAVLFTLGIFGIFLNRKNVIIILMSIELILLAVNLNFIAFSAVLGDLVGQVFALFVLTVAAAEAAIGLAILVVFFRNRGSIAVEDINMMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NHRF3_BOVIN
Sequence: MASTFNPRECKLTKQEGNSYGFFLRIEKDTDGHLVRVIEKGSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAMKKQVDLKALGQSQEPSLNDKKAPSVMNGGAQMWMQPRLCYLVKEGGSYGFSLKTVQGKNGVYMTDIKPQGVAMKAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVTFLLVDKETDKHHSEQKIKVKRETASLKLLPCQPRVVEMKKGSNGYGFYLRESPEQKGQIIKDIDPKSPAEKAGLKNNDLVVAVNGKSVESLDHDSVVEMIRKGGDQTSLLVVDKETDNIYKLAGFSPFFYYQSQELPNGSVKEVPAPTPAPLEVSSPETTEEVGDHKPKLCRLARGEDGYGFHLNAVRGQPGSFVKEVQKGGPADLAGLEDEDVIIEVNGVNMLDESYEKVVDRIQSSGKTVTLLVCGKKAYDYFQAKKIPIVSSMADPLDDDPDPDEGRLEGSEQNSHMAEERERAHSTASHSSSNSEDTEM
What is the function of this protein?
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains.  May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades.  In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins.  May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1.  May potentiate the CFTR chloride channel activity.  Required for normal cell-surface expression of SCARB1.  Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1.  Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney.  May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
What are the official names of this protein?
Na(+)/H(+) exchange regulatory cofactor NHE-RF3, NHERF-3, Na(+)/H(+) exchanger regulatory factor 3, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3.
What is the protein family that this protein belongs to?
Belongs to the NHER family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cell membrane. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes.
Protein: NDKA_CANLF
Sequence: MANSERTFIAIKPDGVQRSLVGEIIKRFEQKGFRLIAMKLIQASEDLLKEHYIDLKDRPFFAGLVKYMQSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFQPEELVDYKSCAQNWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.  Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities.  Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression.  Required for neural development including neural patterning and cell fate determination.  During GZMA-mediated cell death, works in concert with TREX1.  NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase A, NDK A, NDP kinase A, nm23-C1.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HVM42_MOUSE
Sequence: EVKLLESGGPLVQLGGSLKLSCAASGFDFSRYWMSWVRQAPGKGLEWIGEIDPNSSTINYTPSLKDKFIISRNDAKNTLYLQMSKVRSEDTALYYCARSPYYAMNYWGQGTSVTVSS
What are the official names of this protein?
Ig heavy chain V region MOPC 173.
Protein: PYRB_RALPJ
Sequence: MPKTFANPQLTKNGELKHLLSIEGLSRDILTDVLDTAQQFVSVSDSDREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSADVINLNINASSTSKGESLLDTINNLSAMQADMFVVRHASSGAPYLIAEHVAPHVHVINAGDGRHAHPTQGLLDMFTIRHYKKDFSNLTVAIVGDILHSRVARSDIHALTTLGCAEVRAIGPRTLLPGGLEHMGVRVFHNMEEGLKGVDVVIMLRLQNERMSGALLPSAQEYFKAYGLTQDRLALAKPDAIVMHPGPMNRGVEIDSAVADGVQSVILNQVTFGIAVRMAVMGIVAGNND
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: CSPLU_ORYSJ
Sequence: MENRERAGAGAVGSAGSLGLRVGQAVFSSASLLFMSVGVEFFSYTAFCFLVTIMGLVIPWSCTLAMIDVYSILVGCPLRVPGVMVIVVIGDWVLAILSLAAASSSAAVIDLLLQFHGSHCSPRFCGRYQLSAMMAFLSWFLTAASSLFNLWFIASR
What are the official names of this protein?
CASP-like protein 5C1, OsCASPL5C1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYI_STRPI
Sequence: MKLKDTLNLGKTEFPMRAGLPTKEPVWQKEWEDAKLYQRRQELNQGKPHFTLHDGPPYANGNIHVGHAMNKISKDIIVRSKSMSGFYAPFIPGWDTHGLPIEQVLSKQGVKRKEMDLVEYLKLCREYALSQVDKQREDFKRLGVSGDWENPYVTLTPDYEAAQIRVFGEMANKGYIYRGAKPVYWSWSSESALAEAEIEYHDLVSTSLYYANKVKDGKGVLDTDTYIVVWTTTPFTITASRGLTVGADIDYVLVQPAGEARKFVVAAELLTSLSEKFGWADVQVLETYRGQELNHIVTEHPWDTAVEELVILGDHVTTDSGTGIVHTAPGFGEDDYNVGIANNLEVAVTVDERGIMMKNAGPEFEGQFYEKVVPTVIEKLGNLLLAQEEISHSYPFDWRTKKPIIWRAVPQWFASVSKFRQEILDEIEKVKFHSEWGKVRLYNMIRDRGDWVISRQRAWGVPLPIFYAEDGTAIMVAETIEHVAQLFEEHGSSIWWERDAKDLLPEEFTHPGSPNGEFKKETDIMDVWFDSGSSWNGVVVNRPELTYPADLYLEGSDQYRGWFNSSLITSVANHGVAPYKQILSQGFALDGKGEKMSKSLGNTIAPSDVEKQFGAEILRLWVTSVDSSNDVRISMDILSQVSETYRKIRNTLRFLIANTSDFNPAQDTVAYDELRSVDKYMTIRFNQLVKTIRDAYADFEFLTIYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQMQTVFYDILVKITKLLTPILPHTAEEIWSYLEFEAEDFVQLSELPEAQTSANQEEILDTWAAFMDFRGQAQKALEEARNAKVIGKSLEAHLTVYPNEVVKTLLEAVNSNVAQLLIVSDLTIAEGPAPEAALSFEDVAFTVERAAGEVCDRCRRIDPTTAERSYQAVICDHCASIVEENFAEAVAEGFEEK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSXE_SALG2
Sequence: MSEIKDIVVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTVSALRRWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPWLSALDGFSIGMGATGAMFVLGSLREILGNGTLFDGADSLLGGWAKVLRVEIFHTDSPFLLAMLPPGAFIGLGLMLAVKYLIDEKMKKRRAETAPSAVPAGETGKV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.