Protein: RBGPR_DROME
Sequence: MACEVKHCGEIRDFKKVQEYFGLGHDDNWLNAINHAISPTGELIAMAQGEKLAFLSTCWSSHGNGNTYVLGWCGELEDPNQIVTSLTCLPMTQNKSTDGAIEWTCVAVGLCSGMVTFYTDSGVKLFSQCCQEDPVIGVKLQSAPRHSEADSLLYIIYPRCLCFIQGQDILPTLNNCRHNVQRGALERSSYPTADVVPFQKYKFKQEREAVINDAAISTTQRPPTYDYIVQQTIGLGYFAKVHATPPRSSQVLAAGAEPYLGFFQAEEGYKTMSLGEVAKDVIGIAYKNLLGGIFRRAPEPLPSPEESPLPVPTKEAPMRIRCRLYDGKRDGLTLSVAPGGRLAVVTDNLDRVMLVDTHQAIILRVWKGYRDAQCAFVPVKEKSVRGIKTHKRKALFLVIYAPRMGCLDIWALQNGPKVAAFNVSKSGQLMYNNHSPLGSGGSSGSGNSSSQSRKSLAINHCLFLDPSDGSLKEIHIPFHYALSETSSQTSRDIHMLRRLRNQLRTINHGQAKDEALQEIGELASELQTLEVRQQCLEMLLKSKKLQPQVFQSIINAFIKKPLSESTGSEEFVNQIENYKRLTDLYLALSQANQREDNEPPVEYLELSDADLVTINKLVLLLDDGTEKDKPAATREVSFKLQAEHKTEEFVDYLSIFNIDSPDGISLLPEKSDKFGAVSIDLFSQFFAQGLCFGQFKQWINQACLPSRDLLKLIIWFWLEKPFKYNNCDEVVEDMSRIAAMVQTICDLAGEHIHDYAYNAISPWWQEVRELLLESKQFSGLLVAIVCKTVATNLWRNRKEGSCDESSQNEDDERWERISHDEAQWGLLTGKLEDVAVLGAILSKPLICRDPVGPEMSYEPPDCSLKSIVSSGKGIVTELTAKWLISAQLHPSKVLEISPPENELDDESKVKIKDEPTKESVDEDAESEEDLEMAKEVYAASKEAHEPILERLALLRAHFPFSLESGVLLSLMSWQYMVQWSKQLSSLDHLKAALLCLNQFRTPDWALKHGICCMLWNATLKFPLQAAAKLIQKVGRLPVDKMCQQDLEMSAGKVPEFLELSLEFLQHFTASMEHDKRELHFEQSLSEGALPLQFLALQQHHAMPQLLRLQTELCSVLHFVSFFQLRIPKPLTTLFDSMSNKALLADINKELPYVLPAPDLVLQQQRTEFLCRLVTATMDLIREDLEQLYILDHVFYMGKICALADSWEVDKLPILRRQVVELYAFGYDAEAQVLLQDISDDEELGRLLLEIAGRRLNLYAQSSQSTFLKIASVGHQLLAYLDNLKEPMTENNIQIAATKPDEIDVAALDRLLSHAYKYLCRRESKQLPIIGQMYNAVRILQN
What is the function of this protein?
Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of Rab3-GAP and Rab3GAP1, which has both GTPase-activating protein (GAP) activity towards Rab3, and guanine nucleotide exchange factor (GEF) activity towards Rab18 (PubMed:21338884, PubMed:32248620).  As part of the Rab3GAP complex, required for the rapid induction and sustained expression of synaptic homeostasis at the neuromuscular junction (NMJ) (PubMed:21338884).  Also participates in the regulation of autophagy in tissues such as larval fat cells and adult muscles (PubMed:32248620).  The Rab3GAP complex, acts as a GAP for Rab3 by converting active Rab3-GTP to the inactive form Rab3-GDP (PubMed:21338884).  At the neuromuscular junction (NMJ), forms a presynaptic signaling mechanism with Rab3 that regulates progression of synaptic homeostasis at a late stage of vesicle release (PubMed:21338884).  Within this mechanism Rab3-GTP acts, directly or indirectly, to inhibit the progression of synaptic homeostasis, and Rab3-GAP functions to inactivate this action of Rab3-GTP (PubMed:21338884).  The Rab3GAP complex, acts as a GEF for Rab18 by promoting the conversion of inactive Rab18-GDP to the active form Rab18-GTP (By similarity).  Regulates autophagy as part of a Rab3GAP-Rab18 module (PubMed:32248620).  Once Rab18 is activated by the GEF Rab3GAP complex, the Rab3GAP-Rab18 module localizes to autophagosomes, and regulates autolysosome formation and maturation together with the Rab18 interacting effector, the PI3K/Vps34 Complex I (PubMed:32248620).
What are the official names of this protein?
Rab3 GTPase-activating protein non-catalytic subunit, Rab3 GTPase-activating protein regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the Rab3-GAP regulatory subunit family.
What are the subcellular locations of this protein?
Cytoplasm.