PharMolix/UniProtQA huggingface dataset:
Protein: MED14_CHAGB
Sequence: MDNSVHNNSNTTHPDKSRASIVNGVREERVSLSTEPPAGVKGGDNGPITVGDYNKLESRLQGAGMEDSVDELQHITDDVMPLSLLLSRLAQFSHLKLQELILDLASKPLPENTLNGNAKGSMNSSINGNVNAGVNGVPKLPSPALEDTSPESLNKKTMILKFIQDLHSRWVKALVITEWARNADEVGKLIDLRTHLAAKLELYNRAFWNMVNLKHEMAFAKVPSPDLKTALEVLSTGAVHWMPDFGYLPKPPLTTQETLHWLNEIEVVLHMRLQLHEYEQIPEPWKEYKIDNGRVTFTVPGEFEVDLTISDEDFDKQFWFLDYRTIFSPSPSKLSDGARGFIEARVNTILETEGLLGCYKYLHELTLTTKIGEFARQAVELSRTGLWTQTLRVERLNRALGIQYWSQSLHTQDSQSWILLGVHSGKSSDGADDPSSPSRLMLQWFRDGKEVKDADIPLDTDTISTEKLLMTVISRHIKYLLSSIYNSLSSKPRYAQKRGRLSLRISDPPHLDCALTMQTLGADHAVLGIGPWSGNFFFADRPPFGVGWANKINTLRNPVTEAPVVLEQLRWYHMTLHLRTLPKPADWKVLPKAPVPLDEVKRVVYSRASTTREPFHAIFLRNSRWTPQWFAMMSLSLGGDRWWTAEGHGIPGLRINIFTELSITPTDLLLPSSPLFSKLTQHATNIMDQIHDFRVLHQQHIQYTARKASPDGHRTTVVLSADMLPLQPDPDGTTQPTWAGRFIQLDYKGPAPITPSEYRESLADPKSVRRQPTRQKVMIEATVGVLHPTKFRLLRHRLDRDVLYDRRLGHFTLRFQPASGAGIIPLLRSRVQSLDRLVDIVDALHLRGKQISPKKITLREIVFSYGNGSPTMSLSNPRPKFGGNKQRSWEVRLNLAAEQGVDVILEAGNPHLRAIDYLRSAANSVHLKKLPAWFVFTLPLYEALEQLHDSWDAILAKDLGTCYVFHKSLDWLTIRFALSGAKNRLVQLDIRPRDRNGHINWHISRAKTDPNINNENDEFNKILKQRVWSISGNGFKGLGNSATAQWDHGIGPLLAVINEALQSLAGTPPPPQVPTQIQQPQQPSPHPQQAQVQEQRQQPQQQQQANPLQGAAVPGRFPHQLQQGQQLSYQQQARLQQQQRQQQQQQQQQQHMHNQNQAQQAQQRAAMNDINTPVVVLD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RAP2A_HUMAN
Sequence: MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSACNIQ
What is the function of this protein?
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.  In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK.  Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.  More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
What are the official names of this protein?
Ras-related protein Rap-2a, RbBP-30.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443).
Protein: CTPE_ASPNA
Sequence: MSTTTGAFIAGGVAACGAVTVTHSFETVKIRLQLQGELQAKQDAAKKYRGVLHGVKVILQNEGPRGLFRGIGSAYIYQVLLNGCRLGFYEPLRQGLATTIYQDAQVQSLGINVLAGAASGIIGAAAGSPFFLVKTRLQSFSPFLPVGTQHNYKNSFDGLRKIHTSEGVSGLYRGVGAAMVRTGFGSSVQLPTYFFAKRRLMKHLGMEDGPGLHLASSTASGFVVCCVMHPPDTIMSRMYNQTGNLYKGVFDCLFKTIKTEGVLAIYKGYFAHLARILPHTILTLSLAEQTNKIMRRLEDRFLSDSLKENL
What is the function of this protein?
Mitochondrial transporter that does not mediate citrate export from mitochondria to cytoplasm (PubMed:36177470).  Its exact function has still to be determined (PubMed:36177470).
What are the official names of this protein?
Mitochondrial citrate transporter E.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: RL30_ROSS1
Sequence: MKITYRKSAIGYSRDQKATIRSLGLRRLNSVVIHDDTPTIRGMVFKVRHLVSVEEIADDTSPDAETGADLERDGGNRS
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: COXX_STAAE
Sequence: MSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYDQDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPGAVPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLLLINLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GSA2_BACC0
Sequence: MRKFDKSIAAFEEAQDLMPGGVNSPVRAFKSVGMNPLFMERGKGSKVYDIDGNEYIDYVLSWGPLIHGHANDRVVEALKAVAERGTSFGAPTEIENKLAKLVIERVPSIEIVRMVNSGTEATMSALRLARGYTGRNKILKFIGCYHGHGDSLLIKAGSGVATLGLPDSPGVPEGVAKNTITVAYNDLESVKYAFEQFGDDIACVIVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFDEVMTGFRVAYNCGQGYYGVTPDLTCLGKVIGGGLPVGAYGGKAEIMRQVAPSGPIYQAGTLSGNPLAMAAGYETLVQLTPESYVEFERKAEMLEAGLRKAAEKHGIPHHINRAGSMIGIFFTDEPVINYDAAKSSNLQFFAAYYREMVEQGVFLPPSQFEGLFLSTAHSDADIEATIAAAEIAMSKLKA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 2, GSA 2, Glutamate-1-semialdehyde aminotransferase 2, GSA-AT 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C1581_STRCO
Sequence: MTQETTTLTGQSPPPVRDWPALDLDGPEFDPVLAELMREGPLTRVRLPHGEGWAWLATRYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQPDHNRLRRAVAGAFTVGATKRLRPRAQEILDGLVDGILAEGPPADLVERVLEPFPIAVVSEVMGVPAADRERVHSWTRQIISTSGGAEAAERAKRGLYGWITETVRARAGSEGGDVYSMLGAAVGRGEVGETEAVGLAGPLQIGGEAVTHNVGQMLYLLLTRRELMARMRERPGARGTALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMIRGPRTLPCTW
What is the function of this protein?
Catalyzes oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (two isomers of biflaviolin and one triflaviolin).
What are the official names of this protein?
Biflaviolin synthase CYP158A1, Cytochrome P450 158A1, CYP158A1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: DPE1_ORYSJ
Sequence: MATLSLPLPHLTQAIPARARPRPRPLRGIPARLLSCRAAMAVAPDKEEAAAVALDKAVKVAVAAPDRAAVAAVGVGEELPEGYDQMMPAVEEARRRRAGVLLHPTSLRGPHGIGDLGDEAVAFLAWLRDAGCTLWQVLPLVPPGRKSGEDGSPYSGQDANCGNTLLISLEELVKDGLLMENELPDPLDMEYVEFDTVANLKEPLIAKAAERLLLSRGELRTQYDCFKKNPNISGWLEDAALFAAIDRSIDALSWYEWPEPLKNRHLRALEDIYQKQKDFIEIFMAQQFLFQRQWQRIRKYAKKLGISIMGDMPIYVGYHSADVWANRKSFLLDKNGFPTFVSGVPPDAFSETGQLWNSPLYDWKAMEAGGFEWWIKRINRALDLYDEFRIDHFRGLAGFWAVPSESKVALVGSWRAGPRNAFFDALFKAVGRINIIAEDLGVITEDVVDLRKSIEAPGMAVLQFAFGGGSDNPHLPHNHEFDQVVYTGTHDNDTVIGWWQTLPEEEKQTVFKYLPEANRTEISWALITAALSSVARTSMVTMQDILGLDSSARMNTPATQKGNWRWRMPSSVSFDSLSPEAAKLKELLGLYNRL
What is the function of this protein?
Chloroplastic alpha-glucanotransferase involved in maltotriose metabolism.
What are the official names of this protein?
4-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic, Amylomaltase, Disproportionating enzyme, D-enzyme, Protein DISPROPORTIONATING ENZYME 1.
What is the protein family that this protein belongs to?
Belongs to the disproportionating enzyme family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast.
Protein: SYH_AZOVD
Sequence: MSKNIQAIRGMNDILPEQTPLWRYFEKSVAGLLDGYGYRQIRMPIVEFTELFKRSIGEVTDIVEKEMYTFEDRNGDSLTLRPEGTASCVRAVLEHGISGGGQVQKLWYVGPMFRHERPQKGRYRQFHQIGVEVFNLPGPDIDAELIVLTWRLWGLLGLREAVTLELNSLGSSEARARYREALVEYLSARFERLDEDSQRRLSSNPLRILDSKNPETQALLVDAPKLADYLDEDSRQHFEGLKARLDVAGIPYVINPKLVRGLDYYGKTVFEWVTDKLGAQGTVCAGGRYDGLVEQLGGKPTPAVGFAMGVERLVLLLETLERVPAELSRQVDVYFCAFGEAAELAALGLAERLRDALPGLRLAVNAGAGSFKSQLKKADKSGALYALVLGEDELAGRIVGLKSLRAEGEQQSVGWDELGERLAACLRA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_ACISJ
Sequence: MNKIRKGDEVIVLTGRDKGKRGTVSLRKDDSHLVIEGINLVKKHVKPNPMKGTTGGIVEKAMPIHQSNVAIFNAATGKADRVGIKVQADGTRVRVFKSSGAEIKAA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SSRP_BIFLO
Sequence: MPKETGEKLIVQNKKARHDYAIEDKYEAGLALTGTEVKSLREGRASLSEAFISIDRRGEMWLEGANIPEYLNGTWNNHAPKRKRKLLLHRLQITKLARGIEAKGYTIVPLSLYFKDGRVKAEIALARGKKEFDKRQALREEQDKREALRAMRYANMRH
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ANGT_VIBAN
Sequence: MSPLIKLAASSRLHDATHYVLCPFAGGGSGAFRHWRTLSLENEVISVMLYPGREFRIDDPTVINIGTLAEEMIQALKTCNQRIEDTIIVGHSMGAQVAYEASKKLVNQGLFLKGLIISGCQAPHIKGRRLLGECDDKTFIHNLVEIGGCDPSLAKSPEWWPIFLPALRADFTATEQYIFTSLPNDKEGLPIPTLLISGDQDREANFSEIEEWKLWCNKVVDHLVVEGGHFYITEQPQMMLECIRALSTETTA
What is the function of this protein?
Probable thioesterase.  Involved in anguibactin production, but is not essential for virulence or iron transport gene expression (By similarity).
What are the official names of this protein?
Probable anguibactin biosynthesis thioesterase AngT.
What is the protein family that this protein belongs to?
Belongs to the thioesterase family.
Protein: UREF_PROM2
Sequence: MSKSHLLKYLLISPNLPVGGFCYSEGLESYLNTKDLKDSNSVKELIISELKIGQIRLDARLLLDFFDIFNELNEDKNFKNNLQKLLSLDKWILSSKDSVEMRAQQIQMANSLFDLNKEFGFEYLYKKNKKNSWPLAWSWSCYCFEITKLEMVETFLYAWSANQLSAALRIIPIGSTKAQLIQRDLLEIISKVSREIMDKEIDDIYFGNVGLAMAQQNHNELYTKLFRN
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y523_MYCPN
Sequence: MKKWFSSISKKKVSFSTLLLLGSGIVLSSCSNIDKPNVFRTLSQQSVENKVDYSKLPKENKTVRNLVFGTAEYNDGNYVLVVTTETDSSQINFLNGSNNQAVSTENWAGDLGTTVKQVQNRYSTYPKGVKFLIWNDIDPNPVKWNPFARYPVIASDNELAKQTDKDNSDKLRRNDESAIQYREIVTFIQTVYSGSVNNLINQSNVHAQTVGTDVTKAIVIAFRKNNLDQISAHFYNPDNSNGSNAPGSNQPNQDSGNNGSTTPAAPAAAAAKKSYSAGSFGVKRHAVQVSINFLNFLDSVYTPLN
What are the official names of this protein?
Uncharacterized lipoprotein MG348 homolog.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: NEDD8_MOUSE
Sequence: MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLGQ
What is the function of this protein?
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:11696557).  Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.  Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity.  Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (By similarity).
What are the official names of this protein?
NEDD8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8, NEDD-8, Ubiquitin-like protein Nedd8.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Nucleus. Note=Mainly nuclear.
Protein: RK33_GUITH
Sequence: MAKGKGVRIVVTLECKTDQGVYRYHTTKNRRNTPNRIELKKYCPLTQQHEIFKEIK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HTPX_STRGC
Sequence: MLFEQIAANKRRTWFLLVAFFALLALIGAAAGYLWMNSPLGGVIIAFIIGLIYAITMIFQSTEVVMSMNGARQVSEQEAPELYHIVQDMAMVAQIPMPRVYIVEDDSPNAFATGSNPENAAVAATTGLLRLMNREELEGVIGHEVSHIRNYDIRISTIAVALASAITMISSVAGRMMWYGGGRRRNDRDDDSGLGLLMLVFSLIAIILAPLAATLVQLAISRQREFLADASSVELTRNPQGMIRALQKLDNSEPMHRHVDDASAALYISDPKKKGGLQKLFYTHPPISERVERLRKM
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARLY_LISMF
Sequence: MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLAGSLAHVAMLSKCGIIPASEAAEITAGLKILQEKLALGELEFSTVNEDIHLNIEKLLHEEIGPVAGKLHTARSRNDQVATDMHLYLKQAVAEIIQSLKHLRVVLVQKAEANVETIMPGYTHLQHAQPISFAHHLLAYFGMFTRDLERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAVYENSLDGVSDRDFIIEFLSNSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFGMLTVLKGLPLAYNKDLQEDKEGMFDTLETVQTCLDIFAGMIETMKINTEIMEESTQKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGIYLQDVALSHYQEINPLIDDDIYVVLSSKTAVQKRNSYGGTGFDQIKVALENAKKTL
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC1_MORIN
Sequence: MIDRYKHQQLRIGSVSPQQISAWAKKILPNGEIIGEVTKPYTFHYKTNKPEKDGLFCERIFGPIKSGICACGNYRVIGNDKEDPKFCEQCGVEFVDSRIRRYQMGYIKLACPVTHVWYLKRLPSYIANLLDKPLKELEGLVYCDFSFARPIAKKPTFLRLRGSFEYEIQSWKYSIPLFFTTQGFDAFRNREISTGAGAIREQLADLDLPIIIDYSLVEWKELGEERPTVNEWEDRKVGRRKDFLVRRMELAKHFIRTNIEPEWMVLCLLPVLPPELRPIIQIDGGKLMSSDINELYRRVIYRNNTLIDLLTTSRSTPGELVMCQEKLVQEAVDTLFDNGIRGQPMRDGHNKVYKSFSDIIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHRCGLPREIAIELFQTFVIRGLIRQHFASNIGVAKSKIREKEPVVWEILQDVMQGHPVLLNRAPTLHRLGIQAFQPILVEGHAICLHPLVCKGFNADFDGDQMAVHVPLSLEAQAEARLLMFSHTNLLSPAIGDPISVPTQDMLIGLYVLTSGNRRGICANRYNPCNYRNYQNERIDDNKYKYTKTQEKEPFFCNSYDAIGAYRQKRIHLDSPLWLRWRLDQRVITSREAPIEVHYQSLGTYHEIYGHLLIVRSIKKEILCIYLRTTVGHISLYREIEEAIQGFFRACSYGT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RNPA_CHLPN
Sequence: MHPLTLPKQSRVLKRKQFLYITRSGFCCRGSQATFYVVPSRHPGTCRMGITVSKKFGKAHERNSFKRVVREVFRHVRHQLPNCQIVVFPKGHKQRPVFSKLLQDFINQIPEGLHRLGKTKATTGGECTPKSEKCVTAPR
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: MRP4_MOUSE
Sequence: MLPVHTEVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRAKKDSRKPSLTKAIIKCYWKSYLILGIFTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAYGYAAVLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLLLDELPQRKAHVPSDGKAIVHVQDFTAFWDKALDSPTLQGLSFIARPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSTAPGTPTLRKRTFSEASIWSQQSSRPSLKDGAPEGQDAENTQAVQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTRNANGNITETLDLSWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAIFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECKKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDITFTSPAVMNTSNGQPSALTIFETAL
What is the function of this protein?
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells.  Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins.  Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4).  The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4.  Mediates the cotransport of bile acids with reduced glutathione (GSH).  Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable).  Confers resistance to anticancer agents (Probable).
What are the official names of this protein?
ATP-binding cassette sub-family C member 4, Multidrug resistance-associated protein 4.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Its localization to the basolateral or apical membranes is tissue-dependent.
Protein: DEFB3_MOUSE
Sequence: MRIHYLLFAFLLVLLSPPAAFSKKINNPVSCLRKGGRCWNRCIGNTRQIGSCGVPFLKCCKRK
What is the function of this protein?
Antimicrobial activity against Gram-negative bacteria E. coli and P. aeruginosa.
What are the official names of this protein?
Beta-defensin 3, BD-3, mBD-3, Defensin, beta 3.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family. LAP/TAP subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: COAX_THEMA
Sequence: MYLLVDVGNTHSVFSITEDGKTFRRWRLSTGVFQTEDELFSHLHPLLGDAMREIKGIGVASVVPTQNTVIERFSQKYFHISPIWVKAKNGCVKWNVKNPSEVGADRVANVVAFVKEYGKNGIIIDMGTATTVDLVVNGSYEGGAILPGFFMMVHSLFRGTAKLPLVEVKPADFVVGKDTEENIRLGVVNGSVYALEGIIGRIKEVYGDLPVVLTGGQSKIVKDMIKHEIFDEDLTIKGVYHFCFGD
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_ECOLC
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQEVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLAEEKITEVILATNPTVEGEATANYIAELCAQYDVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: NRDR_RHOP2
Sequence: MRCPNCNSLDTQVKDSRPTEDSSVIRRRRVCIACNFRFTTFERVQLRELTVIKRNGRRVPFDRDKLVRSLQISLRKRPVEPERVEQMVSAIVRELESGGEADISSETIGEIVMDHLRKLDDVAYVRFASVYRNFREAKDFEAVLGELSGEEEARPALVRK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PNO1_DEBHA
Sequence: MAAPTAIKDLPESKDVEAVSNEGIEGEEEMLIDAGSVPQENEEGASKKKESSEMVLDESGKPKFSAASKSGMKVKLESRKVPVPPHRMTPLKNTWTKIYPPLVDHLKLQVRMNLKTKTIEMKTNKNTVDQGALQKGADFVKAFTLGFDVDDAIALLRLDDLYIETFEVKDVKTLNGDHLSRAIGRIAGKDGKTKFAIENATRTRIVLADSKIHILGGFTHIRMAREAVVSLILGSPPGKVYGNLRTVASRMKERY
What is the function of this protein?
Required for small ribosomal subunit (SSU) synthesis.  Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein PNO1.
What is the protein family that this protein belongs to?
Belongs to the PNO1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: Y2158_KLEP7
Sequence: MDMDLNNRLTEDETLEQAYDIFLELAADNLDPADIILFNLQFEERGGAELFDPSADWEEHVDYDLNPDFFAEVVIGLADTDGGEINDIFARVLLCREKDHKLCHILWRE
What are the official names of this protein?
UPF0263 protein KPN78578_21580.
What is the protein family that this protein belongs to?
Belongs to the UPF0263 family.
Protein: FAR8_CALVO
Sequence: GANDFMRF
What are the official names of this protein?
CalliFMRFamide-8.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.