Protein: PLEC_CRIGR
Sequence: DGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPGAQNGVRANELQLRWQEYRELVLLLLQWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKSRSKGIYQSLEGAVQAGQLQIPPGFHPLDVEKEWGKLHVAILEREKQLRGEFERLECLQRIVSKLQMEAGLCEEQLNQADSLLQSDIRLLASGKVAQRAGEVERDLDKADGMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPVTQVTVQSTQRRPELEDSTLRYLQDLLAWVEENQRRIDSAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQLSPATRGAYRECLGRLDLQYAKLLNSSKARLRSLESLHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKETQNTGDRLLREDHHARPTVESFQAALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETMRREYSCDRSITVTRLEDLLQDAQDEREQLNEYKGHLSGLAKRAKAIVQLKPRNPAHPVRGHVPLMAVCDYKQVEVTVHKGDQCQLVGPAQPSHWKVLRGPSSEAAVPSVCFLVPPPNQEAQEAVARLEAQHQALVTLWHQLHVDMKSLLAWQNLSRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKAHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFDTLRDELRGAQEVGERLQQRHGERDVEVERWRERVNQLLERWQAVLAQIDVRQRELEQLGRQLRYYRESADPLSSWLQDAKRRQEQIQAVPIPNSQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEGEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVNAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAQAEAAQEKQRALQALEELRLQAEEAERRLRQAQAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVTQLREKAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQRSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREATAATHKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEADRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEILALKVSFEKAAAGKAELELELGRIRSSAEDTMRSKEQAEQEAARQRQLAAEEEQRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQSMLERLRGEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEVERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQRQMEQEKQELVASMEEARRRQCEAEEAVRRKQEELQHLELQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEEIAATQAAAAKALPNGRDALDGPSMEVEPEHAFEGLRQKVPALQLREAGILSAEELQRLEQGHTTVAELSQREDVRQYLQGRSSIAGLLLKPTDEKLSVYTALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEPVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLLVRDHAIRLLEAQIATGGIIDTVHSHRVPVDVAYQRGYFDEEMSRILADPGDDTKGFFDPNTHENLTYLQLLERCVEDPETGLHLLPLTDKAAKGGELVYTDTEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIVITVVEEQERKGQLCFEGLRALVPAAELLESGVISHELYQQLQRGERSVREVAEADSVRRALRGASVIAGVWLEEAGQKLSIYEALKKDLLQPDVAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPELHEKLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGMVDPSKSHRVPLDVAYARGYLDKETNRALTSPRNDARVYLDPSSQEPATYSQLQQRCRADQLTGLSLLPVSEKAVRARQEEVYSELQARETLEKARVEVPVGGFKGRTMTVWELISSEYFTQEQRQELLRQFRTGKVTVEKVIRIVITIVEEVETQRQERLSFSGLRAPVPASELLAAKILSRAQFDQLKEGKTSVKDLSEVGSVRTLLQGSGCLAGVYLEDSKEKVTIYEAMRRGLLRPSTATLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSGTTISLFQAMKKGLVLREHAIRLLEAQIATGGIIDPVHSHRLPVDVAYQRGYFDEEMSRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLKGAEKTEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSSMSLWEVMQSDMIPEDQRARLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQNLASYDYVRRRLTAEDLYEARIISLETYNLFREGTKSLREVLEMESAWRYLYGTGSVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLKRCRRDDGSGQMLLPLSDARRLTFRGLRKQITVEELVRSQVMDEATALQLQEGLTSIEEVTKTLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDRLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLRLLPLKEKKRERKTSSKSSVRKRRVVIVDPETSKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAITENLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVSAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSSKGYYSPYSVSGSGSTTGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPPASLGGPESAVA
What is the function of this protein?
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes.  May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
What are the official names of this protein?
Plectin, PCN, PLTN, 300 kDa intermediate filament-associated protein, IFAP300, Plectin-1.
What is the protein family that this protein belongs to?
Belongs to the plakin or cytolinker family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, hemidesmosome.