PharMolix/UniProtQA huggingface dataset:
Protein: APDB_EMENI
Sequence: MGFVNTLTQASDQENQRLRASPQVFKLFVLILFVLLVLKIRRHRANRITNQYGRQICELHGDARVAKFAFSKQLSDQGKALAGDEPFIIRNGRARELVVTKPEHIYDFYKGDTKPCSLLGHAVGALAGERWSMIRRYFDPAFSFQSARQAIPELSASIDRWLDDLPLQGTGTGKGFALEIKKPCRFLPLRLAAEFVYGEIFDDKLFSALLDLNVLHEVILHDVIANKRLATRLGCWFDRAAAKRMEEFRSRWMEFNLGIIQSARGASKACPAERIYHGVEKGDLKLEEFLHTLDEILFANVDVSSAVLGTLFEHLAVNTAFQQKLRAEIETHIQTRTHTPDTDSDIDINTETGKYLSKQDTLMNFAVMEAMRLSPAFDCDFAAFSLPECTAVPKEIGGYRVPARCPVVIDAKRLNADRATWGKDGDTYRPERFRDIPPSKSRYGFMRFGVGAASGRCLGKHLADTLFKLTLIAVIERYSLHSVHDGPEVELREVVVRV
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones (PubMed:17369821, Ref. 5).  The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA (PubMed:17369821, PubMed:20828130).  The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit (PubMed:20828130).  The growing polyketide chain then elongates into a tetraketide (PubMed:20828130).  The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation (PubMed:17369821, PubMed:20828130).  Alpha-methylation step during polyketide synthesis is a prerequisite and a key checkpoint for chain transfer between PKS and NRPS modules (PubMed:25494235).  The downstream NRPS module contains the condensation (C), adenylation (A), and thiolation (T) domains and catalyzes the incorporation of tyrosine via the formation of the L-tyrosinyl-thioester and the amide linkage between L-tyrosinyl-thioester and the tetraketide (PubMed:20828130).  The bimodular assembly line is terminated with a reductase (R) domain that facilitates formation and release of the tetramic acid product (PubMed:20828130).  Because apdA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase apdC (PubMed:17369821, PubMed:20828130, Ref. 5).  ApdC appears to operate with different stereoselectivity in different PKS cycle (Ref. 5).  Combined with apdC, apdA is proposed to synthesize preaspyridone A via about 20 enzymatic steps (PubMed:20828130).  A number of oxidative steps performed successively by the cytochrome P450 monooxygenases apdE and apdB are required for the conversion of preaspyridone A to aspyridone A (PubMed:17369821).  The cytochrome P450 monooxygenase apdE is responsible for the oxidative dephenylation of preaspyridone A (Ref. 5).  Finally, the predicted FAD-dependent monooxygenase apdD and the acyl-CoA dehydrogenase apdG may be involved in the transformation of aspyridone A into aspyridone B (PubMed:17369821) (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase apdB, Aspyridones biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SELD_COLP3
Sequence: MTSIRLTQYSHGAGCGCKISPSVLDVMLKSSLALPVNDALLVGNSTKDDAAVFDIGNDQGVISTTDFFMPIVDDPTDFGKIAACNAISDIYAMGGKPIMAIAILGWPVNLLAPEIAQQVLDGARAICAEAGIPLAGGHSIDAPEPIFGLAVTGLINNAHIKRNNTAEVGDLLYLTKPLGIGIMTTAEKQGKLLPEHAQLAPQAMKTLNVIGQKFAELEVVTAMTDVTGFALLGHLLEMCQGSGVAAVIDFEQVPRLDFVNDYIDQGCVPGGCERNFISYGEHVGPLSPKQKILLCDPQTSGGLLVAVKPQGKEAFEALCQENGLNLQPIGELVAATSPTVSLLS
What is the function of this protein?
Synthesizes selenophosphate from selenide and ATP.
What are the official names of this protein?
Selenide, water dikinase, Selenium donor protein, Selenophosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Protein: KAD4_PONAB
Sequence: MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKANTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPIQSKEAY
What is the function of this protein?
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity).  Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity).  Also displays broad nucleoside diphosphate kinase activity (By similarity).  Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity).  Plays a protective role in the cellular response to oxidative stress (By similarity).
What are the official names of this protein?
Adenylate kinase 4, mitochondrial, AK 4, Adenylate kinase 3-like, Adenylate kinase isoenzyme 4, GTP:AMP phosphotransferase AK4.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: MUTH_ECOSE
Sequence: MSQPRPLLSPPETEEQLLAQAQQLSGYTLGELAALAGLVTPENLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLREDWEELMDMIVLGQVERITARHGEYLQIRPKAANAKALTEAIGARGERILTLPRGFYLKKNFTSALLARHFLIQ
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COFC_HALMA
Sequence: MRLAVPVSGSTPKTRLASVLSPDERRDFTEAMLADVVDAVTSAGHEPEVISTAPLDCAVPVTVDDRGLDPLVNDLLASTVTDDEGALAVVMADLPLVTRESIERLLAPEADVVLAPGLGGGTNAFVCRHPEFRVDYHGASIRDHRETARDVGASVTEVDSRRLATDIDEPDDLAEVLLHSDGAAADWLKQSGFELTATGGRVDVERFR
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: SYH_ALTMD
Sequence: MAKTIQAIRGMNDCLPEISGTWQKVESVLRQVVASYGYQEIRTPIVESTDLFKRSIGEVTDIVEKEMYTFEDRNGDSLTLRPEGTASCVRAGNEHGLLYNQQQRLWYMGPMFRHERPQKGRYRQFHQFGVETYGMDGPDIDLEVILLSARFWKSFGIEQHVKLQINTLGSNEARAAYRDTLVAFLKERADQLDEDSLRRLETNPLRVLDSKNPDVQAAIADAPALIDHLDDESKAHFDTLCARLTQAGIEFEINPRLVRGLDYYNRTVFEWVTDSLGAQGTVCAGGRYDGLVEQLGGKATPAVGFAMGIERLVLLLTTLTEEGQDTSFADVYVTAMGDDAQPYAIEVSEALRNALPNIRIMMHCGGGNFKKQLKRADKTGARLALLLGSDEMQSREVGVKPLRDGQEQVTVSFDTLADKVAEMLSAK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBIX_ECOHS
Sequence: MMYHIPGVLSPQDVARFREQLEQAEWVDGRVTTGAQGAQVKNNQQVDTRSTLYAALQNEVLNAVNQHALFFAAALPRTLSTPLFNRYQNNETYGFHVDGAVRSHPQNGWMRTDLSATLFLSDPQSYDGGELVVNDTFGQHRVKLPAGDLVLYPSSSLHCVTPVTRGVRVASFMWIQSMIRDDKKRAMLFELDNNIQSLKSRYGESEEILSLLNLYHNLLREWSEI
What are the official names of this protein?
PKHD-type hydroxylase YbiX.
Protein: MUTH_SHEON
Sequence: MKSIIPPQNLSELLKRANMMAGISLAQIATHRGINVPNNLKRDKGWVGQLIEMELGATAGSKPEQDFLHLGVELKTIPIDNHGKPLETTYVCVAPLTNIEGLTWQNSLVCHKLQRVLWVPVEGERHIPVGERRIGTPTLWEPDPQEQALLQQDWEEIMELIALGKVEKLTARHGEVLQLRPKAANSKAMTHSISEDGSLKMTNPRGFYLKTAFTAMILNKVFG
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRVA_RANTE
Sequence: PMTDVLAAGDISKAVAAFAAPESFNHKIEEEELGLILKVLLAAGDKDGDGKIGVDEFVTLVSE
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions.
What are the official names of this protein?
Parvalbumin alpha.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=Cytoplasmic in muscle. Secreted in cutaneous mucus.
Protein: KR192_HUMAN
Sequence: MCYGYGCGCGSFCRLGYGCGYEGCRYGCGHRGCGDGCCCPSCYRRYRFTGFY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 19-2.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 19 family.
Protein: CLPX_RHORT
Sequence: MSKSSGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREEHKTSLVKSRDGVPSPKDILKVLDDYVIGQQHAKKVLSVAVHNHYKRLSQAGKNSDVELAKSNILLIGPTGCGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIILKLLQASDYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLDRIISARGKGSSIGFGADVRDPEARRTGEVLRAVEPEDLLKYGLIPEFVGRLPVLATLDDLDEDALVDILTTPKNALVKQYQRLFEMESTQLSFKEDALRCIALKAIARKTGARGLRSIMEGILLDTMFDLPGMEGVEEVVVNKEVVEGRAKPLFIYSDQRTSADGASA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TBG_CHLRE
Sequence: MPREIINLQVGQCGNQVGSEFWRKLCQEHGIAKDGRLEDFATLGGDRKDVFFYQADDEQYIPRAILLDLEPRVINGIQTSDLRNLFNPENIFISKEGGGAGNNWASGYTQGEAVQETLLDMIDREAEYCDSLEGFNMCHSIAGGTGSGMGSYMLELISDRYSKKLIQTYSVFPNQSESSDVVVQPYNSLLTLKRLTLHADAVVVLDNTALDKIAVERLHLHKPDVQQINSLIATVMAASTTTLRYPGYMNNDLVGLVASLIPTPRCHFLMTGYTPLTAENAAGQVTSNIRKTTVLDVMRRLLQPKNIMVSTHTKSRDIANAKYISILNIIQGEVDPSQVHKSLQRIRERKQANFIEWGPASIQVALSKKSPYVQTAHRVSGLMLANHTSVRHLFNKVLRDYEKLMGPKQERQAFMQAYRDVPRFADAAGGGTALLEEFADAKEVVQDLANEYAACESADYIQRQMMAS
What is the function of this protein?
Tubulin is the major constituent of microtubules.  The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
What are the official names of this protein?
Tubulin gamma chain, Gamma-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center.
Protein: EF1B_THEON
Sequence: MADYNLVGVIKVMPTDPDVNLDELEEKLKAVIPEKFGLAKVEREPIAFGLVALKFYVLGRDEEGYSYDEVADLFRQVENVESAEVETVSRI
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: FLGH_IDILO
Sequence: MRSLLFSLTALVLAGCVQTPHKPMPDDPYYAPVLPEERAQPVVPTGSLFQDAYADNLYSDIKARRLGDIITVTLREQTTASKTATTETSKESTAELAAPTAFGRNITVGGNPLSAGINGTREFSGDGSSDQSNQLNGEITVTVIKVLPNGNLIVRGEKWMRINTGDEYIRLTGMIRPQDITAANQIPSTRVANARIEYSGTGSLAQVQEQGWLTRFFNSPIWPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: ATS9_HUMAN
Sequence: MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRVL
What is the function of this protein?
Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site).  Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.
What are the official names of this protein?
A disintegrin and metalloproteinase with thrombospondin motifs 9, ADAM-TS 9, ADAM-TS9, ADAMTS-9.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum.
Protein: GUC2F_BOVIN
Sequence: MFLAPWPFSHLMLWFVTLGRQRGQHGLASFKLLWCLWLLVLMSLPLQVWAPPYKIGVVGPWTCDPLFSKALPEIAAQLATERINKDPALDLGHSLEYVIFNEDCQASRALSSFISHHQMASGFIGPANPGYCEAASLLGNSWDKGIFSWACVNYELDSKNSHPTFSRTLPSPIRVLLTVMKYFQWAHAGVISSDEDIWVHTAYRVASALRSRGLPVGVVLTTGQDSQSIQKALQQIRQADRIRIIIMCMHSTLIGGETQTHLLEWAHDLQMTDGTYVFVPYDTLLYSLPYKHTPYKVLRNNPKLREAYDAVLTITVESQEKTFYQAFEEAAARGEIPEKLESDQVSPLFGTIYNSIYFIAQAMNNAMKENGWASAASLVQHSRNVQFYGFNQLIRTDANGNGISEYVILDTNWKEWELHSTYTVDMETELLRFGETPIHFPGGRPPRADAQCWFADGRICQGGINPTFALMVCLALLIALLSINGFAYFIRHRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSHASVSFQITSEVQSGRSPRLSFSSGSLTPATCENSNIAIYEGDWVWLKKFPSGNFGDIKSVESSASDIFEMMKDLRHENINPLVGFFYDSGVFAIVTEFCSRRSLEDILMNQDVKLDWMFKSSLLLDLIKGMKYLHHREFAHGRLKSRNCVVDGRFVLKVTDYGFNDILETLRLSQEEPSAEELLWTAPELLRAPRGSRLRSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAKEIIERIKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIQERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGMRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSHSTVTILRTLGEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPPPVGKDGQVGHGLQSVEIAAFQRRKQKSSW
What is the function of this protein?
Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:9571173, PubMed:9175772).  Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:9571173, PubMed:9175772).  May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
What are the official names of this protein?
Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Photoreceptor outer segment membrane; Single-pass type I membrane protein.
Protein: RTCA_SALEP
Sequence: MARIIALDGAQGEGGGQILRSALSLSMITGQPFEMSDIRAGRAKPGLLRQHLTAVRAATEICGAQVNGDELGSQQLRFTPGPIRGGEYRFAIGSAGSCMLVLQTVLPALWFADGSSRVEVHGGTHNQAAPSADFICRVWEPLLARMGISQRTTLIKHGFYPAGGGAAATVVEPATSLRGLTLISRGETLRTTAEALLAAVPYHVGEREVATLEAHFPLAEKNVVALEGGCGPGNALLLMIQSEQLTELFAAFGVKGTSAEAVANQVAHEARRYLASPAAVGEHLADQLILPLALAGEGAFTVARASAHLLTNIAVVERFLPVRFSCEATESGYLVRVSD
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4G2_BOVIN
Sequence: MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
What is the function of this protein?
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection.  Cleaved by some caspases and viral proteases (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 4 gamma 2, eIF-4-gamma 2, eIF-4G 2, eIF4G 2, p97.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4G family.
Protein: RL1_SHEB9
Sequence: MAKLTKRMRVIREKVDGTKSYDINEAVALLKELATAKFVESVDVAVNLGIDPRKSDQNVRGATVLPHGTGRDVRVAVFTQGANAEAAKAAGAELVGMDDLAEKIKAGEMNFDVVIASPDAMRVVGMLGQILGPRGLMPNPKTGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFTPVQLKENLEALVSALKKAKPAVAKGIFVKKISISTTMGAGVAVDQATLETTV
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PENO_PENCR
Sequence: MKHTLPSALVTLWRDSPGYESARSRTFNQRVPPELPYAIVKPKNVEQIQQAVQLAIDLDKQIRIRSGGHSLAGWTLCADSILIDLVDFMHLEYDATTAIASASPSATSAQLNDLLVPHGRFVPVGHCGDVGLGGFFLQGGMGLNCRSYGWACEYLVGVDLITADGEYKHCSESENADLFWAARGAGPEFPAIVTRFFIRTRPAAAKHEKSTFIWPVACSDAVVSWILKILPELHADIEPLVVSTIVPGPNIAAILVQFLVFLGTNETGAEKLEPSLTAMPDGTIMEFKGVSTSIQQEYVSQEGTMPRDSRYICDSVWFKDGIDFVAVTRRMFREFPRDRSMVYWEPKYPTSRRKLPDMAFSLQADQYLALFAIFEDSQQDQEQGIRIQEFIQEIEPYVLGTFAADGVPAVRKTQYWSAEVIERLYSVCQKWDPAHRLGCTLLDPTRKMKS
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:26213965).  The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (Probable).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase penC then forms 3-geranylgeranylindole (3-GGI) (Probable).  Epoxidation by the FAD-dependent monooxygenase penM leads to a epoxidized-GGI that is substrate of the terpene cyclase penB for cyclization to yield paspaline (Probable).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase penP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase penQ (PubMed:26213965).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase PC-15 which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase penD (Probable).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase PC-16 and the P. simplicissimum ptmI-ortholog not yet identified in P. crustosum, leads to the production of the prenylated form of penijanthine (Probable).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase PC-22 (Probable).  A series of oxidation steps involving 4 cytochrome P450 monooxygenases (PC-21, PC-05, PC-23, PC-20) and a FAD-dependent monooxygenase (PC-14) are required for the transformation of PC-M4 to penitrems A and E.  Synthesis of these final products is proposed to proceed via penitrems D and C (PC-21, PC-05, PC-14) and penitrems B and F (PC-21, PC-05, PC-14, PC-23) (Probable).
What are the official names of this protein?
FAD-linked oxidoreductase penO, Penitrem biosynthesis cluster protein O.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: MSD5_AMAPH
Sequence: MSDINATRLPIFWFIYFPCVGDNVDNTLTRGER
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:24613547).
What are the official names of this protein?
MSDIN-like toxin proprotein 5.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: RDGC_SHEPA
Sequence: MWFKNLTVYRFNKPFSVDPDSLEKSLEDFTFSPCSSQDISKFGFSKAMGKHGETLIHTAGDRHLICATKEEKILPSQVIKEALEEKVSQIEAEENRKLAKKEKDAMKDEITTTLLPRAFSRRSQIRALILPEIQMVLVDSSSAAKSEELMALLRKAIGTLPIIPMSFKTPIETQLTEWLKEGKTPAAFEMQDEAELKSDSDEGGIVRFKQQDLSENEVLAHIEVGKQVHKLALHFGQSIAFLLQSDAAIKRLKFSEEFRAGNDDLGNDDPMARLDADFALMSSELIALINATVEALGGLEDSI
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.