PharMolix/UniProtQA huggingface dataset:
Protein: RS9_BURMS
Sequence: MIGNWNYGTGRRKSAVARVFIKAGKGDIVVNGKPISDYFSRETSLMIVRQPLELTNHAQTFDIKVNVSGGGETGQAGAVRHGITRALIDYDATLKPALSNAGFVTRDAREVERKKVGLHKARRAKQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: MIAB_ECOK1
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGSFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTDDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_BURP0
Sequence: MPELPEVEVTRRGIEPFVAGRRVERVDVRTAMLRWPVPAGFAEMLRSREVLRVERRGKYLLFEVDAGWFIVHLGMTGTLRVLPNDAPPPAPAKHDHVDWIFDEFVLRFRDPRRFGAVLWHPRDAGDVHAHPLLASLGVEPFSAAFSGALLFGRTRGRTVSVKQALLAGDIVVGVGNIYASESLFRAGIRPTTAAGRVSLPRYERLADAVRATLADAIERGGSTLRDFVGSNGESGYFQLDCFVYDRAGEPCRVCGAPIRQIVQGQRSTYFCPNCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: IDI_DINSH
Sequence: MKDLVPAWIDGALRPVGKLEAHQRGLRHKAVSVFVMRGPETLIQRRALDKYHTPGLWANTCCTHPLWDESPADCAVRRLREELGITGLYPAHRDRIEYRADVGNGLIEHEVVDLFIAEAPANLKVAPNPEEVAEVKWVDLYELNAQVKRRPERYTPWLRIYLAEHSERIFGTVATS
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_NAUPA
Sequence: MKFDTMLAIGIGGFIGAILRAYTAGLVNSAVKHDIPFGTLSVNLIGSLLLGMFIGAIQYGGIQNPYIKSMLTTGMMGAFTTFSTFAVESFFLFKNALYIQALSYILLNVIGCIILAGAGFKGIEAILK
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NQRD_HAEDU
Sequence: MANNNLKKLLLSPISDNNPIALQILGICSALAVTTQLQTAFVMAIAVSLVTAFSSMFISMIRNYIPNSIRIIVQMAIIASLVILVDQILRAYVYDLSKQLSVFVGLIITNCIVMGRAEAFAMKSAPLESFVDGIGNGLGYGAMLVIVAFLRELIGSGKIFGVTVLQTIQDGGWYQANGLFLLAPSAFFIIGFVIWAIRTWKPEQVEK
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y266_RICFE
Sequence: MPKKFTTRKGDIYTIDTPNEENLFKSVINKNTSEAFRYISQFNFPLSDNIKTIRYFAIDEDKPNNVGTSHSTLSLIAVINNDLETLNLLINFGFDINNHSGINYITPLGLAADKGYKEIVKLLCEQDDIKVQNALYYAIRGENKSIEIIDLLVQKGAIIKPEHIELAISHSNLSVFEYLFEKKLPDIEKNNLKLIGSSPAISSIDCILGEASKYQNTEVIKFLLSSGYKPEQKYIDEFFVSAADNGRLKTCITLKANIEEHTRLEGLSKYQNYLKDKYHDYYKTHIIFLSKFSYTDEPVEMFMFDNESNLLLLSMSRPLRSKLSSKDSYIIHDAIKEIFNNTHLNIKELELARFKARIEFIKITTDEDLVPLSNKLAPLFSPELIHDLSKLEEELFPEVKLAGLAD
What are the official names of this protein?
Putative ankyrin repeat protein RF_0266.
Protein: EFG_DESVV
Sequence: MARVVPIDMQRNIGIMAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTCFWREHRVNIIDTPGHVDFTIEVERSLRVLDGAVCVFDAVAGVEPQSETVWRQADRYGVPRICFVNKMDRIGASFERCVGMIRDRLRAKPIPVQLPIGAEDRFEGVIDLITGKAVTFDKASKGQTFNVGDVPAEYRDQYDAMRFEMIEAVAEEDEALMEKYLGGEELTVEEIISCVRKATIARNIVPVLCGSAFRNMGVQPLLDAVVDFLPSPVDIEQMKGVNPDKEEETIVCPCDDKEPLAALVFKLFSDPYIGHLSFCRIYSGFIESGMTVLNANTGKRERVGRLLKMHANKREEIKWAGAGDIVALVGLKLASTGDTICDEKRPVVLESLDIPEPVIEVAIEPKTKADRDALSAALAKLAKEDPSFRVKGDDETNQTLIAGMGELHLEIIVDRLTREFSVNANVGKPQVAYRETITKPGKADTKHVKQSGGRGQYGHAVIEIEPNPGKGYEFVNSITGGVIPKEYIAPIDKGIQDALKSGILSGFPTVDIKVNLVFGSYHDVDSSEQAFYVTGSMAIKEAIAKSGPVLLEPIMDVEVVTPDEYLGDVMGDLNGRRGKVQSMEARVGAQSIRAQVPLSEMFGYATDLRSKTQGRATFSMQFHHYERVPAALAEELVKKKG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP3_ROTP5
Sequence: MKVLALRHSVAQVYADTQTYVHDDSKDEYENAFLISNLTTHNILYINYSVKTLKILNKSGIAAVEIQSPDELFALIRCNFTYDYENNTVYLHDYSYYTNNEIRTDQHWVTKTDIIDYLLPGWKLTYVGYNGKDTRGHYNFSFTCQNAATDDDIIIEYIYSSELDFQTFLLRKIKERMTTSLPIARLSNRVFRDKLFPSIVNIHKRVVNVGPRNESMFTFLNFPTIKQFSNGAYLVKHTIKLKQERWLGKRVSQFDIGQYKNMLNVVTTIYYYYNLHSSKPVIYMLGSAPSYWIYDIRQYSDFTFETWDPLDTPYSTTHHKELFFDKDVTKLKDNSILYIDIRTDRGNMDWKEWRKVVEQQTVSNLSIAYKYLSTGKAKVCCVKLTAMDLELPITAKLLHHPTTEIRSEFYAILDVWDISTIKRFVPKGVFYAFINNVTTENVFIQPPFKLRTLPNDYIVALYALSNDFNPRQDIINLINKQKQSLITVRINNTFKDEPKVNFKNIYDWTFLPTDFEIKDSIITSYDGCLGIFGLSTSLSSKPTGNNHLFIINGTDKYYKLDQYANHMGISRRSHQVRFSESATSYSGYIFRDLSNNNFNLIGTNIENSVSGHVYNALIYYRYNYAFDLKRWIYLHSIGEVTVEGGKYYEHAPIELIYACRSAKEFAALQDDLTVLRYANEIEGYINKVYSITYADDPNYFIGVRFDSIPYEYDVKVPHLTFGVLFISDNMIHDVITVLKKMKTELFKMEVSTSYTYMLSDGIHVANASGVLSTYFKLYNMFYRNHITFGQSRMFIPHITLSFSNKRTVRIENTRLKINSIYLRKIKGETVFDMSE
What is the function of this protein?
Counteracts the host innate immune response thanks to its phosphodiesterase that degrades the 5'-triphosphorylated, 2'-5' linked adenylate oligomers produced by the host cell IFN-inducible 2',5'-oligoadenylate synthetase (OAS).  The host RNaseL is therefore not activated.
What are the official names of this protein?
Protein VP3.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP3 family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. There are about 11 to 12 copies per virion.
Protein: DAPLE_MOUSE
Sequence: MDVTVSQLVELFLQSPLVTWVKTFGSFGSGHQDNLTLYMDLVDGIFLNQIMLQIDPRPSNQRINKHVNNDVNLRIQNLSILVRNIKTYYQEVLQQLIVMNLPNVLMIGKDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLDLPDVAPEELEALSRNMVFHLRRLIDERDECTELIVDLTQERDYLQTQQPPSPGKFSSPDSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTLQKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPAPKKKNHWIGAKALVKLIKPKKEGSRERLKSTTDSPPWQLEPSDPASPSPSQALRSQTENPDNPPSGPNCVEERDTHNGPVGKGPGDLKPKRGSPRGGSVDRTDTSTDPAVKSWPSEPGSRTFSTSATTAALSSSTPIPKHLGRTKGCNSDDNLCEPSSEPDGPYHRQQASRPNSLESSRNASSNSSPLSLKGSSDHLHSRCESFSSADLIPSRDPATLSRDGNTSGRGLLGRHEYPPPRNGPVSQETIQKKGAASTHTGVRPHSASPSSEMVTLEEFLEESNRGGSPTHDTPSCRDDLLSDYFRKAHDPPALGGQPGPPARKDGAKMPTSFVAPTIKMSINTSEGQQLKPGHYVKPNLRPSEAEALAGMPSRQVQPPQSLSLGRPRQTTMTQNCHMPVSRSASLSRAFSLASADLLRASGPEACRPESPQKPGGHEAAGARETSTHSLQGSHILARERTPIVGKADSPSPGQGTRGRPLDTRRFSLAPPKEERLAPLQQSATAPALATGCSSGSNPQIQHFSPTVAPAVRTKSKVPQHSGEVATVAPVRPGLGTSEGDGGPGHGYSEGLLTKSPGRSSDLPPHVKRGPDDFSQGSSSKSTPASPEPGGDPQTVWYEYGCV
What is the function of this protein?
Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling.  Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling.  Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation.  Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling.  Promotes apical constriction of cells via ARHGEF18.
What are the official names of this protein?
Protein Daple, Coiled-coil domain-containing protein 88C, Dvl-associating protein with a high frequency of leucine residues.
What is the protein family that this protein belongs to?
Belongs to the CCDC88 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction. Note=Enriched at apical cell junctions.
Protein: GAFA_DICDI
Sequence: MAEDLEISKGSKEEQYENLLPQIEGLLTGENNQIANLANVTAALKEQFNFFWVGFYLVDTENELVLAPFQGPIACTRIRKGRGVCGTAWQQEKTLIVPDVEKFPGHIACSSLSKSEIVLPLYKQGNIIGVLDVDSDKLNSFDEIDEKYLTQILKLLDN
What are the official names of this protein?
GAF domain-containing protein A.
What is the protein family that this protein belongs to?
Belongs to the free Met sulfoxide reductase family.
Protein: PORTL_BPBPP
Sequence: MAEQTERKLLLSRWGQLRTERESWMSHWKEISDYLLPRAGRFFVQDRNRGEKRHNNILDNTGTRALRVLAAGMMAGMTSPARPWFRLTTSIPELDESAAVKAWLANVTRLMLMIFAKSNTYRALHSMYEELGAFGTASSIVLPDFDAVVYHHSLTAGEYAIAADNQGRVNTLYREFQITVAQMVREFGKDKCSTTVQSLFDRGALEQWVTVIHAIEPRADRDPSKRDDRNMAWKSVYFEPGADETRTLRESGYRSFRALCPRWALVGGDIYGNSPAMEALGDVRQLQHEQLRKAQAIDYKSNPPLQLPVSAKNQDISTVPGGLSYVDAAAPNGGIRTAFEVNLDLSHLLADIVDVRERIKASFYADLFLMLANGTNPQMTATEVAERHEEKLLMLGPVLERMHNEILDPLIELTFQRMVEANILPPPPQEMQGVDLNVEFVSMLAQAQRAIATNSVDRFVGNLGAVAGIKPEVLDKFDADRWADTYADMLGIDPELIVPGNQVALIRKQRADQQQAAQQAALLNQGADTAAKLGSVDTSKQNALTDVTRAFSGYT
What is the function of this protein?
Forms the portal vertex of the capsid.  This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection.  The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel.
What are the official names of this protein?
Probable portal protein, Gene product 21, gp21, Head-to-tail connector.
What is the protein family that this protein belongs to?
Belongs to the podoviridae head-to-tail connector protein family.
What are the subcellular locations of this protein?
Virion.
Protein: EFTU1_YERPP
Sequence: MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAFDQIDNAPEEKARGITINTSHVEYDTPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEGEAEWEAKIIELAGYLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTVKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREDIERGQVLAKPGSIKPHTTFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNINMIVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVIA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 1, EF-Tu 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEF_HV1Z2
Sequence: MGGRWSKSSIVGWPAIRERIRRTDPAADGVGAVSRDLEKHGAITSSNTRGTNADCAWLEAQEESEEVGFPVRPQVPLRPMTYKGALDLSHFLKEKGG
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Host cytoplasm, host perinuclear region. Virion. Secreted. Note=Predominantly found in the paranuclear area, probably in the TGN. Correct localization requires PACS1. Also associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Also incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved (By similarity).
Protein: CHLL_CYAPA
Sequence: MKLAVYGKGGIGKSTTSCNISVALAKRGKKVLQIGCDPKHDSTFTLTGHLIPTIIDTLQEKDFHYEDIWPEDVIYKGYAGVDCVEAGGPPAGAGCGGYVVGETVKLLKELNAFDEYDIILFDVLGDVVCGGFASPLNYADYCLIVTDNGFDALFAANRIAASVREKARTHQLRLAGLIGNRTTKSDLIEKYTENVPIPILQLLPLIEDIRISRVKGKTLFEMSESNPELSPICDYYLNIADQILAKPEGIIPNEVLDRDLFTLLSDFYLNMDSSESSNLTLV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: SLYX_RHOPS
Sequence: MANDGSLSDRIDALEMRLSYQDETIETLNQTVTAQWKQIDTLTRQIAALSERLQQAESSVATPANERPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: SSRP_MYCA9
Sequence: MSKKPADGRKVIATNRKARHNYSIIDVYEAGVQLVGTEVKTLREGKASLVDAFATVDDGEVWLRGVHIPQYDHGTWTNHAPLRNRKLLLHRAQIDMLVGKTRDGNLTLVPLSLYFLDGKVKVELALARGKQAHDKRQDIAKRDASREITRELGRRAKGM
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: BGAL_PSYIN
Sequence: MREFSEIIKARDWENQEVTHQHVVQAHAPLHAFHSKQAALDNQASEFQQLLNGQWRFQLFAKPEAVPNHCINIDFDDSAWSDITVPSNWQLQGYDKPIYTNVKYPFADNPPFVPADNPTGVYRLNFTLPTAWKERKNTVIFDGVNSAFHLWCNGIWVGYSQDSRLPAEFDLSCHLQAGDNQLTVMVLRWSDGSYLEDQDMWWLSGIFRDVCLLSKPLISIRDITVSTELDACFNHGSINVVTQLSEQSSQYTAQVQLFDAQLQPVTKLVGAPFGERMIDEKGPANDRAEHKIAVPSPHKWSSESPYLYRVVISLVDNEGQVVDSEAYQVGFRVVEMSNGQLKLNGEALLIRGVNRHEHHPEKGHAISYEDMLVDIKLLKQNNFNAVRTAHYPNHPLWYELCDQYGLYVVDEANLETHGQFPMSRLSNDLSWLNAYMRRMTRMVERDKNHPSIIIWSLGNESGLGHHHHAMYQWTKRRDPTRPVQYEGGGADTAATDIIVPMYARVNKDITLPNAPDVVPKMAIKKWLSMPNEQRPLILCEYAHAMGNSLGSFDKYWQAFREYPRLQGGFIWDWVDQGLTKIDDNGDNYWAYGGDFGDQINDRQFCINGLVFPDRSLHPTVYEAKKAQQFYQFSLVDGDQLKVKIDSENLFIESMDETLCWSVTEAGYVIASGEMELHVTAQSSKILTLLESYPEQKIGCDYFLNIEIVLNKDKPWATKGFVVATEQVALASIAQLTNVPLIESGAPRLSEDKNKITVAGTGSGAEFELEIDKQQGVISQWLVRGENKILQGPKDNFFRAPLDNDIGTSEADCIDPNAWVTQWDTAGIANLVPHCIAIEAVTLARSVLVKVEFGHYVENKLLISSHWQYTINNQGEVQIDVNVNLAKSLSPLPRIGLELILPDSEKPVNWFGRGPHENYPDRILSAHIARHCCSIEEMHTPYIFPSENGLRCDVKDAIVGDLTVSGDFHLAVSRYSQMNIAQAKHVNDLINDHQLYVRLDAFHMGVGGDDSWSPSVHDEFLLNKEHYHYQMILAFN
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: CSHA_BACLD
Sequence: MTITFQDFQLSSDLTKAIKRMGFEEATPIQAQTIPLGLANKDVIGQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRARVLPIYGGQDIGRQIRALKKNPHIIVGTPGRLLDHINRRTMRLQTVNTVVLDEADEMLNMGFIEDIESILSNVPAEHQTLLFSATMPAPIKRIAERFMTNPEHVKVKAKEMTVSNIQQFYLEVHERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELTEALNLRGYTAEGIHGDLTQAKRMVALRKFKQGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGRAGKTGMAMTFITPREKDMLRAIEQTTKRKMDRMKAPTLDEAIEGQQQVTVDRIRTIIEENNLNFYMTAAAELLEDHDSVTVVAAAIKMMTKEPDNTPVRLTEEAPLRTKRNKNHHHRSSKRRDGGGYRGKNNRSSYDKKRSSNDRRQKKSYNS
What is the function of this protein?
DEAD-box RNA helicase possibly involved in RNA degradation.  Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase CshA.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. CshA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y9043_DICDI
Sequence: MSSVEITQTDSNNNTEEYNNDNSNSNNDSSNQSTELPKLHEAIINGNFEDVKKMIDSGNVNLEEGDFGGLHPLHFAARMGNIAIGQYLLDKGVDINAENNYGSTPILEAVRRGEVEFVKFLISRGANLSIGDIDDNTPLHLAVMCEDGELIPILLDAGSPLDAKNKDDETPIQVTEDKDIIDYINEFKALKEKQQQQQQK
What are the official names of this protein?
Ankyrin repeat-containing protein DDB_G0279043.
Protein: FGOX3_PENRF
Sequence: MTKLFTPLHVGRMELANRIAMAPMTRYRASDNHVPLPIMKDYYAQRASVPGTLLITEATTISARAGGYANAPGIYNDAQIAAWKEVTDAVHAKGSYIYVQLWAVGRPANPQLLQAEGGYDLVSSSATAVSADAPTPRALSETEIYAWIADYAQAARNAVAAGFDGVEIHAANGYLIDQFTQDICNTRTDAWGGSVQGRARFALEVSRAVVEAVGADRTGIRFSPWSTFQGMRMKDPKPQFEYLAVQTAKLGLAYVHLVESRIAGGADVDATDRLDFFLRAYGKASPVIFAGGYDAESAVRAVDVEYADYDAIVGIGRPFISNPDLPFRVQNGIPFVPYDRATFYVPKDPKGYTDYAFSAEFQKAIEAAA
What is the function of this protein?
Chanoclavine-I aldehyde reductase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28902217).  The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689).  The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689).  The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217).  The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217).  The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689).  Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689).  Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217).  The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).
What are the official names of this protein?
Chanoclavine-I aldehyde reductase fgaOx3, Isofumigaclavine biosynthesis protein fgaOx3, Old yellow enzyme homolog fgaOx3, OYE fgaOx3.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: ATP6_RHOCA
Sequence: MFDGEAIRWFEFFVPTNSTLWMAIGVLMIALLMVVGTLRRAIVPGRIQSLAELTYGFIHKMVEDVAGKDGLVYFPYIFTLFLFILFSNFLGLIPMAFTPTSHIAVTGVMAMGVFIGVTALGFMKHGSHFLNLFWVSAAPLPLRPILAVIEVISYFVRPVSHSIRLAGNMMAGHAVMEVFAAFAPLILFSFVGVIVTPLSVLAIVAMYALEILVAFVQAYVFTILTCVYLKDALHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cellular chromatophore membrane; Multi-pass membrane protein.
Protein: GRCA_VIBC3
Sequence: MIQGIQITKAANDDLLNSIWLLDSEKNEARCVAALKGFEADQVVSINDLGQFESREVAIEAAPRIEGGQHLNVNVLKRETLEDAVAHPEKYPQLTIRVSGYAVRFNSLTAEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.