PharMolix/UniProtQA huggingface dataset:
Protein: UBA4_ASPFU
Sequence: MENLEQTCASLRAQIAATEAQLAGLKRELEIAEQAAEVKAQSTTRTITAEDGKTNETREWPLLSEEYKRYGRQMIVPQLGLQGQLKLRAARVLIVGAGGLGCPAALYLAGAGVGTLGLVDGDTVENSNLHRQVLHRSKNVGTFKVDSAIEYLRELNPHPTYVPYRAHLTPQEAPGIFKDYDIVLDCTDNPATRYLISDTAVLLGKPLVSASALRTEGQLMVLNYPPRPVGDKSGGPCYRCVFPKPPPANSVVSCADGGILGPVVGTMGVLQALEAIKVITSPAVNPSASPPSLLIFSAYSTPLFRTIRLRARRANCAVCSADASVTLETLKNGSTDYVFFCGVAGLEATLSPEERISPLEFKKRHPKEVPQDGGRINKEPTIIDVREKVQFDICSLENSINIPISTILSSASSPTNVDANAQPSLPFWLPRELASADSTDPIYVVCRHGNDSQIAVRRLKELGLDRGGQRYVGDIQGGLRAWREQIDPDWPEY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Also essential during biosynthesis of the molybdenum cofactor.  Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a.  Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and mocs2a.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions (By similarity).
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase uba4, Common component for nitrate reductase and xanthine dehydrogenase protein F, Ubiquitin-like protein activator 4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_STRTD
Sequence: MSNQLIYTGKAKDIYSTEDENVIKSVYKDQATMLNGARKETIKGKGVLNNQISSLIFEKLNASGVATHFIERISDTEQLNKKVTIIPLEVVLRNVTAGSFSKRFGVEEGLDLKTPIVEFYYKNDDLDDPFINDEHVKFLNIANDEQIAYIKDETRRINELLKDWFEQIGLRLIDFKLEFGFDKDGKIILADEFSPDNCRLWDAEGHHMDKDVFRRDLGSLTDVYEVVLEKLQGLK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: NCKX_DROME
Sequence: MLQPTTCSKQQQQRQQPAIATAAVGGAAVQELLRKAAAKDHGALAAATATATAASTTATTATAATASRNSSNTWCHSDDMLSAGRSRSSSTTIDFNSRRRRGRLRGHAPSDLAMNKQHQATILDECVNIFKRLVLLTLKTISATTITKAKTRSRTAAQLPATSAASATSSRGASAEQLLHPSSRSRCRSRRCLRLPIYSILLLCLTTQGLGLGDAAKPRPAKQHFGGSNSNSPNQNQNHNDVLGGVGAPSQTSGEDEAEIMYPFQSGEQMFGLEEDQEQDPELNSNAVPGSDEDNAGNQRGINDTHNDNSTTTKTPLFPKDLFTKEQLENGAVILHIIGVIYMFVALAIVCDEFFVPSLDVIIEKLGITDDVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGMCALFSKTVLSLTWWPLFRDCSFYSISLLVLIYFFRDNRIFWWEALILFTIYIGYVAFMKWNVQVETCVKKMITKNKVTRVRSTDQLMPAGNAANSSETSMATQPGGSVTSRAASETRSGPPGSSNAGATGNSSGGGGTSGSTQTGAKFRHGLLQLMIHTIDPLHDGKVDEKATQLHAIASLKVLLDATKPQRGGATTSAANHVKINLKETTLADRPNGNIDTTLDSPSLSGRRPSWIEQRVKIQTRKFSIKAPEIEDEPEPLSMAWPDTARKRLTYVLVAPLLVPMWLTLPDTRTPRGKRFFPVTFIGSIVWIAAFSYLMVWWANVAGDTARIPPEVMGLTFLAAGTSIPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPIPWLLYGIIYGAPVEVNSVGMVCSITILFMMLVFVVMSIACFRWRMNKGLGFTMFLLYFAFVAVSLMFEYDVITCPF
What is the function of this protein?
May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks.  Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+).
What are the official names of this protein?
Sodium/potassium/calcium exchanger Nckx30C, Na(+)/K(+)/Ca(2+)-exchange protein Nckx30C.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CCA_METM7
Sequence: MKKLNIGDYNDILNEVLNDISPTEVEKKELKVFSDKIIAKIKDISKKPVVDIIQVGSTARDANLKDDHDIDIFLRFERETDRDTLKESGLKIGKEVIDYFNGKSWVEYAEHPYVSGEIEKFNLDIVPCYGIENCEKIISAVDRTPLHNEFLIMSYKNKNLSDDIRLLKKFLKGLGIYGSDLKTAGFSGYLCELLILKYGGFLTLISDVKTWKPTKSIVLNEIYEMYDLKKDHVFSKFDDPLVVYDPVDLNRNVAAALNEENLCKFIFYSKMFLKNPSKDFFYGFDKKITDFLNRRERGYLLTLEIKRPENIVEDVIYPQMEKIQKSINKLVKEHDFEYLRYQNFADENTCYLSWEFLVNELPSVKLRIGPPVYSEPGVMNFITHNEHYFVKGCNVCAYKTRKYKNIQILFEDIVNGKFRKIITYPKYVCPENAEIRLGTFVERT
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: CTFB_CLOAB
Sequence: MINDKNLAKEIIAKRVARELKNGQLVNLGVGLPTMVADYIPKNFKITFQSENGIVGMGASPKINEADKDVVNAGGDYTTVLPDGTFFDSSVSFSLIRGGHVDVTVLGALQVDEKGNIANWIVPGKMLSGMGGAMDLVNGAKKVIIAMRHTNKGQPKILKKCTLPLTAKSQANLIVTELGVIEVINDGLLLTEINKNTTIDEIRSLTAADLLISNELRPMAV
What is the function of this protein?
Catalyzes the transfer of CoA from acetoacetyl-CoA to acetate, butyrate and propionate (PubMed:2719476, PubMed:2383002).  Shows also low activity with valerate, isobutyrate and crotonate (PubMed:2719476).  Plays an important role in the metabolic shift between the acid-producing and solvent-forming states of C. acetobutylicum (PubMed:2383002).  Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation (PubMed:2719476, PubMed:2383002).
What are the official names of this protein?
Acetoacetyl-CoA:acetate/butyrate CoA-transferase beta subunit, Butyrate--acetoacetate CoA-transferase subunit B, Coat B.
What is the protein family that this protein belongs to?
Belongs to the 3-oxoacid CoA-transferase subunit B family.
Protein: PFKAM_PONAB
Sequence: MTHEEHHATKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIIEIVDAITTTAQSHQRTIVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGHLATMAGLAAGADAAYIFGEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, muscle type, ATP-PFK, PFK-M, 6-phosphofructokinase type A, Phosphofructo-1-kinase isozyme A, PFK-A, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: USPF_ECOLI
Sequence: MNRTILVPIDISDSELTQRVISHVEEEAKIDDAEVHFLTVIPSLPYYASLGLAYSAELPAMDDLKAEAKSQLEEIIKKFKLPTDRVHVHVEEGSPKDRILELAKKIPAHMIIIASHRPDITTYLLGSNAAAVVRHAECSVLVVR
What are the official names of this protein?
Universal stress protein F.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
Protein: SECA_ANADE
Sequence: MFNYVLKKVLGTKNERELKRLRPLVARVAELEPRMKALRDEDFPRLVAEWKQQVREKGRTLDDVMPEAFALVREAGVRALGMRHFDVQLIGGAVLHSGKIAEMKTGEGKTLVATLPCVLNALSGRGVHVVTVNDYLARRDAEWMGRLYRFCGLSTGVIVHGLTDRERQQAYGSDITYGQNNEFGFDYLRDNMKFRLQDYVQGELNFAIVDEVDSILIDEARTPLIISGPSDESSELYARVNAVIPSMIRDQDFTVDEKSRTIVMTDAGVEKMEKKLSVQNLYAPEEIETLHHVEQALRAHHIYRNEVDYVVKEGEVLIVDEFTGRLMPGRRWSDGLHQAVEAKEGVKIEAENQTLATISFQNYFRMYSKLAGMTGTADTEAEEFAKTYNIDVVVIPTNQKNVRKDAEDVVYKTEGEKFDALCTEIEQRHGTGQPVLVGTVSVAKSEVVSALLKRRGVPHSVLNAKHHQREAEIVAQAGRKGAVTISTNMAGRGTDIILGGNAEMMAKHEVGPEPDAPMEGEEEQAFLERKADWAKRLEQALEKLKAQTAAEHEEVVKLGGLHIVGTERHESRRIDNQLRGRAGRQGDPGSSIFYLSLEDELMRIFGSDRIQGLMGRMGMKDGEQIEHPWLTKAIEGAQKKVEAHNFDIRKNLLEYDDVMNQQRRSIYRLRRMVLGFGAGVPVVEYEEDPKTRKKTRHEQVFTWADAGEHMLDLVEDLVVEMVGASCPSRVADWDLEGLSANIREQFGVEMKFTPPVGRPQEARRALEEQVFNVVEKLYRAKEEELGKDPEGIPVLRRWEQYLYLQAIDQQWKDHLLSMDHLRQGIGLRGYGQKDPKQEYKKEGYEMFVQMTWRVKSAVIGNLLRLQLVRQETAEELEAKRLAMQRKALQRITASHAESAGDGDAKPAPKQETVVRQHPKVGRNDPCPCGSGKKYKKCHGATEAAV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CDSA_MYCBO
Sequence: MTTNDAGTGNPAEQPARGAKQQPATETSRAGRDLRAAIVVGLSIGLVLIAVLVFVPRVWVAIVAVATLVATHEVVRRLREAGYLIPVIPLLIGGQAAVWLTWPFGAVGALAGFGGMVVVCMIWRLFMQDSVTRPTTGGAPSPGNYLSDVSATVFLAVWVPLFCSFGAMLVYPENGSGWVFCMMIAVIASDVGGYAVGVLFGKHPMVPTISPKKSWEGFAGSLVCGITATIITATFLVGKTPWIGALLGVLFVLTTALGDLVESQVKRDLGIKDMGRLLPGHGGLMDRLDGILPSAVAAWIVLTLLP
What are the official names of this protein?
Phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PHAR3_RAT
Sequence: MDQTPPARSEPLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKQGLLEMMEQDSESKACSPKEGSQPAQSEPSAGEQETLTSEGVQPGSPSASGTDQASQDELLSSDAHPDDTAKMSSASSGEEADAGNLLPTTDEPSQEALSGSLDSPPRTLERSASQLPSPPLLPTPPPKASSKATKNVTGQAALFQGSSMKNNEPVLRGQLPTPTGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRECRGSPKKRMDVRLSRTSSMERGKERDEAWSFDGASENKWTAAKDSEENKENLILSSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVARAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP
What are the official names of this protein?
Phosphatase and actin regulator 3, Scaffold-associated PP1-inhibiting protein, Scapinin.
What is the protein family that this protein belongs to?
Belongs to the phosphatase and actin regulator family.
What are the subcellular locations of this protein?
Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold.
Protein: YNFB_ECO55
Sequence: MKITLSKRIGLLAFLLPCALALSTTVHAETNKLVIESGDSAQSRQHAAMEKEQWNDTRNLRQKVNKRTEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVITP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: MINE_PSEU2
Sequence: MNIFDFFRDRKKGSTASVAKERLQIIVAHERGQRSTPDYLPALQKELVEVIRKYVNIESDQVQVALESQGSCSILELNITLPDR
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: YIDD_HALH5
Sequence: MKRFFIGCIRLYQKFISPLTPPTCRFYPTCSHYGIEAIQRFGVLKGGWLTIKRISKCHPFHRGGIDPVPEKKQEK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
Protein: MSCL_LIGS1
Sequence: MLKEFKEFISRGNVMDLAVGVIIGGAFTAIVNSLVKYIINPFLGLFVGAIDFSDLVFKIGNATFRVGSFLNAVINFLIIAFVVFLMVKGINKVLRQDKKEEAPAPKDPQLEVLEEIRDSLKKLDK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ELP2_XENTR
Sequence: MSAPIVQLAHAAFSVNRCPSCVSWSRTGILACATCHSIALYDPQKNVVISTLNGHTGRVNCVHWVQKNDCSAETELVSGGSDKKVIIWAIEKNKCEQPVAAEGHTEVVNAVHAVYTQRSENELLIVSAASDCTVRLWLRRNVKTECLQTLSFGKGFVLDVCISFLPGSLVPVLACGADDSRIHLYVLQNEQFEKTQVLHGHEDWIRGVEWAVTGQNLFLASCAQDCLIRIWKIFRKTAKENSKTEDENSIKLKENIFKVKEKDTETSYAVTLETVLTGHENSIYAVHWQPSFSRDGSIVQPMSLLSASMDKTMILWEPDEESGVWLEQVRVGEVGGNTLGFLGCQFSPDKSMILAHAFHGALHLWSRAPNKQNEWIPMVIISGHFDSVQDMRWDPDGQFVITVSADQTTRLFGPWKKKGQSHVTWHEIARPQIHGYDMQCLAMIGRFQFVSGADEKVLRVFAAPRNFIENFSNISCISVEKLLLNEDTNLPEGATVPALGLSNKAVFHGEILIQSTQEEGKYNSVSEQYSQPNFQPLNLTEPPTEDHLLQNTLWPEVQKLYGHGYEIFAVACNSAKTVIASACKASKREHAAIILWSTTSWKQLQSLSYHNLTVTQMAFSPDDEFLLVVSRDRNWSLWKKQEGIPEQTEPTFTLYASTDKNSCVHSRIIWACDWTPDSKYFVTGSRDKKVIVWGDCSLPSMNEEKSSALIRPCSSLLDTGDSITAVSVSQVLALDGSYIIAVGLDCGIIQLYKWKHSGTVNDWLKCLAMDQSLLSHTLTVKQLCWRSCLGRAGHDDRDNGDWIQLASCGADHCVKIFDVYRKAL
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).  The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
What are the official names of this protein?
Elongator complex protein 2, ELP2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ELP2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CHED_BURPS
Sequence: MSGLPIATNLYFDAHFHRHGVKLLPNEFYTTREDMVLVTVLGSCVAACLHDPIGRIGGMNHFMLPDDGADPSAAASESMRYGAYAMEVLINELIKAGGRRERFEAKVFGGAAVLAGMTTINIGDRNADFVRRYLALERIRITAEDLQGVHPRKVAFMPHTGQAMVKKLRVQAPDVAAREAALAREAVDPHGERAPRVRPRVELFGTPAPKAQAKPRIELFGMRAMQPATRKQEA
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: APVA_ASPTN
Sequence: MTLNNLQALLRRVAAREDSGHVVVYGMGNTKAFKSYSYQDLLRVAIKASVALRKTSDLHPGSVILLHFDNHWDNIVWFWAASFAGCLPAISASFSNDASQRTAHIERLSTTLMHPLCLTNERIMADFAGQDAVQPLAVETLVLNGDVSFEALPQEHPEPSLSDDALLLFTSGSSGNSKGVCLSHGQILASISGKYAVRPLPDNTSFLNWVGLDHVAAIVEIHLQAMYALKTQVHVPAADILSSPATFLQLLEKHRVSRTFAPNFFLAKLRDLLQENDSLPEPRRWDLRSLEYVASGGEANVTKTCDRLSEYLVAFGAPKDVIVPGFGMTETCAGSIFNTRCPEYDKSRSAEFASVGTCMPGISMRVTDLSNNALPSGEIGHLQLTGPVVFKRYFNNTSATQEAFTPDGWFKTGDMGCIDENGCLTLTGRAKENMIINGVNHSPHEIETALDKIPGLTPSYSCCFSFFPSGGETEEICVVYLPTYSPDDLAARAQTADAISKTVLMSTGSRPHVLPLEREALPKSSLGKLSRAKIKAAYEKGEYATYQNANNELMRRYRESTRAEPQNDLEKTLLEVFTRSLSITDDAFDVKTPIFDVGINSVELIRLKRDIEDHLGMAASAIPMIMLMTHSTVRDLATALEKLQGPREYDPVVTLQSHGHKNPLWLVHPGAGEVLVFINLAQYIVDRPVYALRARGFNDGEQPFETIEEATASYYNGIRSRQPHGPYALAGYCYGSMLAFEVAKMLESHGEEVRFLGSFNLPPHIKMRMRELDWKECLLHLAYFLDLVSQERSREMSVELAGLSHDEILDSVIQNANMERYAELSLNRPLLVRWADVAYELHRMAFDYDPAGCVAGMDVFFSIPLAIAAASKTEWRNVHLSQWEDFTRTVPKFHDVAGEHYSMIGPDHVFSFQKTLRKALDERGM
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of aspulvinones (PubMed:29305695, PubMed:23841722, PubMed:28791090).  The nonribosomal peptide synthetase apvA is responsible for the production of aspulvinone E, the core structure of aspulvinones (PubMed:29305695, PubMed:23841722, PubMed:28791090).  ApvA first activates 4-hydroxyphenylpyruvate (HPPA) through its A domain to AMP-HPPA (Probable).  The HPPA unit is then loaded to the T domain and eventually transferred to the TE domain (Probable).  Upon loading of another HPPA unit to the T domain, the TE domain promotes the enolate formation on the unit attached (Probable).  The next step involves head to tail Claisen condensation, followed by the keto-enol tautermerization and a nucleophilic attack on the carbonyl carbon to yield the furanone partial structure (Probable).  A spontaneous oxidation at the beta-carbon of the thioester might occur in aerobic condition (Probable).  The TE domain then catalyzes the hydrolysis of the thioester, followed by spontaneous decarboxylation, dehydroxylation and keto-enol tautermerization to give the aspulvinone core (Probable).  Aspulvinone E is highly unstable and converted to isoaspulvinone E in the presence of light (PubMed:29305695).  The structural diversity of the aspulvinones suggests that other tailoring enzymes are involved and have still to be identified (Probable).
What are the official names of this protein?
Nonribosomal peptide synthetase apvA, Aspulvinone E synthase.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: RL15_ECO55
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEVRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: DUT_ANAMF
Sequence: MLKVKILRLASGYGLPLPSYATPKSAGLDLYAAVDSKLVVHPGGRCAVKTGVALELPDGYEAQIRSRSGLAANFGICVLNAPGTIDSDYRGEITVVLSNFGSEDYVISRGDRVAQMVIAPVERVEWEEVNSITATSRGEGGFGSTGT
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: COAD_CUPTR
Sequence: MVSAVYPGTFDPMTRGHEDLVRRASNIFDELVVGVAHSPNKRPFFSLEERISIAREVLGHYPNVRVEGFSGLLKDFVRKNNARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETMFLTPSDQYQFISGTFVREIAVLGGDVSKFVFPSVERWLQEKIAKPE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIPA_ECOL6
Sequence: MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDEDVEDDEGVGEVRVHRVNHAPANAQEHEAARPSPQHQYQPPYASAQPRQPVQQPPEAQVPPQHAPRPTQPVQQPVQQPAYQPQPEQPLQQPVSPQVASAPQPVHSAPQPAQQAFQPAEPVAAPQPEPVAEPAPVMDKPKRKEAVIIMNVAAHHGSELNGELLLNSIQQAGFIFGDMNIYHRHLSPDGSGPALFSLANMVKPGTFDPEMKDFTTPGVTIFMQVPSYGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDIIREVKDANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: Y475_BLOPB
Sequence: MRDDVNQSFYDVLEFVRIFRRKNKLQREIVDNEKKIRDNQKRVLLLGDLSDYIKSETSIEGIQVIIANMRNDYEDRVDEYIIKNAELSKERRELSKKLKNFKESTID
What are the official names of this protein?
UPF0265 protein BPEN_475.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: YAFP_ECOLI
Sequence: MNNIQIRNYQPGDFQQLCAIFIRAVTMTASQHYSPQQISAWAQIDESRWKEKLAKSQVWVAIINAQPVGFISRIEHYIDMLFVDPEYTRRGVASALLKPLIKSESELTVDASITAKPFFERYGFQTVKQQRVECRGAWFTNFYMRYKPQH
What are the official names of this protein?
Uncharacterized N-acetyltransferase YafP.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: IKZF3_MOUSE
Sequence: MEDIQPTVELKSTEEQPLPTESPDALNDYSLPKPHEIENVDSREAPANEDEDAGEDSMKVKDEYSDRDENIMKPEPMGDAEESEMPYSYAREYSDYESIKLERHVPYDNSRPTGGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRAFLQNPDLGDAASVEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDANYNPGYMYEKENEMMQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSVYPIALTRADMPNGAPQEMEKKRILLPEKILPSERGLSPNNSAQDSTDTDSNHEDRQHLYQQSHVVLPQARNGMPLLKEVPRSFELLKPPPICLRDSIKVINKEGEVMDVFRCDHCHVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRAMLK
What is the function of this protein?
Transcription factor that plays an important role in the regulation of lymphocyte differentiation.  Binds to GGGAA.  Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state.  Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
What are the official names of this protein?
Zinc finger protein Aiolos, Ikaros family zinc finger protein 3.
What is the protein family that this protein belongs to?
Belongs to the Ikaros C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: UBIB_SALDC
Sequence: MTPGEVRRLYFIIRTFLSYGLDELIPRMRLTLPLRLWRYSLFWMPNRHKDKLLGERLRLALQELGPVWIKFGQMLSTRRDLFPPQIADQLALLQDKVAPFDGRLAKAQIEEAMGGLPVEAWFDDFDIQPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIQADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFENSPMLYIPEVYSDYCSQNMMVMERIYGIPVSDVAALEKNGTNMKLLAERGVKVFFTQVFRDSFFHADMHPGNIFVSHEHPENPQYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALTRALKEKAPFWVEKMPEIPELVYDSLRQGKYLQHSVDKIARELQVNHVRQSQSRYLLGIGATLLLSGSFLLVNRPEWGLMPGWLMVGGVVVWLVGWRKTR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NTPPB_PSEPK
Sequence: MLPLLLASSSAYRRELLARLHLPFTWASPDIDEQRLDGEPPVELVRRLARQKAEALAGSHPRHLIIGSDQVAVLGEQVLGKPHTFERACEQLLECSGQQVSFLTGLALLNSATGQCQVDCVPFTVTLRELSREQVERYVAAEQPLDCAGSFKAEGLGVSLFQSTHGCDATSLIGLPLIRLVDMLTKEGVMVP
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.