PharMolix/UniProtQA huggingface dataset:
Protein: NOP5C_ARATH
Sequence: MLVLFETSGGFALFKVLDEGKLSNVEDLGTEFYSAESARRMGLHKFLKNNCDDGEILAVADPKLGDIITEKLDIECVHNDAVMELLRGVRSQLTELLSGLDDNDLAPVSLELSHILARYKLKITSDKVETMIILSISLLDDLDKELNTYTTSVCELYGLHFPELANIVQDNILYAKVVKLMGNRINAATLDFSEILADEVEAELKEASMVSTRTEVSDLDLMHIQELCDQVLSIAEDKTLLCDDLKNKMNKIAPNLTALVGELVGARLISHCGSLWNLSKLPWSTIQILGAEKTLYKALKTKQATPKYGLIYHAPLVRQAAPENKGKIARSLAAKSALAIRCDAFGNGQDNTMGVESRLKLEARLRNLEGGDLGACEEEEEVNDKDTKKEADDEEEPKTEECSKKRKKEAELETVEDPAKKSKQEGVTGLLLLMLLISLIYFFSVNQLLW
What is the function of this protein?
Required for 60S ribosomal subunit biogenesis.
What are the official names of this protein?
Putative nucleolar protein 5-3, Nucleolar protein 58-3.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: UBA4_VANPO
Sequence: MVEVSAEVLAELELLKKENAKLRSQLDSQKSDKLPMSLQEFQRYGRQMIVEETSGIEGQLKLKNSKVLVIGAGGLGCPALLYLAGAGIGTIGIVDNDTVDNSNLHRQVLHDSSKVGMLKCESARQRINLLNPHVNVKTYPVRLDYSNAFTIFENYDYVLDCTDTPITRYLVSDVAVNLGMTVISASGLGSEGQLSILNFKNEGPCYRCFYPTPPPPNSVSSCQEGGVIGPCIGLVGTMMAVETLKVIYDIYTLENFKPFLMMYSGFPNQTLRTFKMRGRQNNCECCGLDPKITRAAIESGLVNYFEFCGSRNYNLCTDEERISSEIYKTEFIDCNEKDHILIDVRPRHHFNISHFNHAINIPVKELKGMKGSLDILKESVPNVSQDSKVIVLCRYGNDSQIATRLLKDEFKINDVKDVKGGFFKYIDEEDHSYPKY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1.  Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase UBA4, Ubiquitin-like protein activator 4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RODA_BACSU
Sequence: MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTDWIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGAKSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPVGLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAKSVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPESTTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALIVIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFNS
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell wall elongation (PubMed:9622350, PubMed:27525505).  Also required for the maintenance of the rod cell shape (PubMed:9622350).
What are the official names of this protein?
Peptidoglycan glycosyltransferase RodA, PGT, Cell elongation protein RodA, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase, Rod shape-determining protein.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. MrdB/RodA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PNCB_YERPE
Sequence: MTQDASPILTSLLDTDAYKLHMQQAVFHHYRHITVAAEFRCRSDELLGVYADEIRHQVTLMGQLALTSDEFIYLSSLPFFQDDYLHWLRDFRFKPEQVSVAVHDGKLDIRIAGLWCEVIMWEVPLLAVISEIVHRRRSTQVTTDQAVQQLRTKLEQFNALSADIDITHFKLMDFGTRRRFSREIQHTVVSTLKDEFPYLVGTSNYDLARTLALAPVGTQAHEWFQAHQQISPTLANSQRVALQVWLDEYPNQLGIALTDCITMDAFLRDFDLAFANRYQGLRHDSGDPIEWGEKAIAHYEKLGIDPMKKVLVFSDNLDLEKALFLYRHFYQRIKLVFGIGTRLTCDIPDVKPLNIVIKLVECNDKPVAKLSDSPGKTICQDPAFVDQLRKAFALPLVKKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: KDPA_CLOBA
Sequence: MMNLVLQYGLYILILVVLAIPLGNYIGKIMNGEKVFLSKILTPCENFIYKMLHIDKDEDMSWKKYSFSVLAFSIISLIVLFLIHIFQGFLPLNPEKVSGTSWDLAFNNAVSFVTNTNWQGYSGESSLSYFTQMMGLTVQNFVSAAVGISVLFALIRGFIRVKQKGIGNFWMDITRTVLYILIPLSIVVSLALVSQGVVQNFKQYETVSLLEPITLEDGTVVTEEVVPLGPAASQIAIKQLGTNGGGFMGTNSAHPIENPTVLSNLFEMISLLLIPVALCFTFGRNIKDRRQGIAIFIAMGIMLVVAMGIIGVNEQMGTPQMALNGQVDLSTINQAGGNMEGKEARFGIATSSTWATFTTAASNGSVNSMHDSYTPIGGMIPMLLMQLGEVVFGGVGCGLYGMIGFAILAVFMAGLMVGRTPEYLGKKIEPFEMKMAVLVCLATPIAILIGSGIASILPETVNSLNNSGAHGFSEVLYAYTSAGGNNGSAFAGFAANTPFINISIGLSMLFARFVPMMGTLAIAGSMVKKKKVAESVGTLPTHNAMFIGLLIFVVLLIGALSFFPALALGPIAEFFQMLG
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KANK3_HUMAN
Sequence: MAKFALNQNLPDLGGPRLCPVPAAGGARSPSSPYSVETPYGFHLDLDFLKYIEELERGPAARRAPGPPTSRRPRAPRPGLAGARSPGAWTSSESLASDDGGAPGILSQGAPSGLLMQPLSPRAPVRNPRVEHTLRETSRRLELAQTHERAPSPGRGVPRSPRGSGRSSPAPNLAPASPGPAQLQLVREQMAAALRRLRELEDQARTLPELQEQVRALRAEKARLLAGRAQPEPDGEAETRPDKLAQLRRLTERLATSERGGRARASPRADSPDGLAAGRSEGALQVLDGEVGSLDGTPQTREVAAEAVPETREAGAQAVPETREAGVEAAPETVEADAWVTEALLGLPAAAERELELLRASLEHQRGVSELLRGRLRELEEAREAAEEAAAGARAQLREATTQTPWSCAEKAAQTESPAEAPSLTQESSPGSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDGDSENGGAEPPGSSSGSGDDSGGGSDSGTPGPPSGGDIRDPEPEAEAEPQQVAQGRCELSPRLREACVALQRQLSRPRGVASDGGAVRLVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQSESPPGSQTATPGEGECGDNGENPQVQ
What is the function of this protein?
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
What are the official names of this protein?
KN motif and ankyrin repeat domain-containing protein 3, Ankyrin repeat domain-containing protein 47.
Protein: SYY_STACT
Sequence: MTNELLKDLEWRGLIYQQTDAEGLENILNKEQVTLYCGVDPTADSMHIGHLLPLLTLRRFQNHGHKPIVLIGGGTGMIGDPSGKTDERVLQTEEQVEQNVRGIGNQMDKIFDFSGKEAAQLVNNRDWLGKISLIDFLRDYGKHVGVNYMLGKDSVQSRLENGISYTEFTYMILQAIDFGHLNREYNCKVQIGGSDQWGNITSGIELMRRMYGQTEAYGITIPLVTKADGKKFGKSEAGTVWLDAEKTSPYELYQFWINTTDADVIKFLKYFTFLDKEEIERLEQSKEEAPHLREAQKALAENVVRFIHGEGALNDAIRISEALFSGDLKALSSDELREGFKDVPQAEVSNATTNIVDFIVEAGISSSKRQAREDVSNGAIYINGEREQDLKYEISEADKIDNEFTIVRRGKKKYFMVKYK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y300_METJA
Sequence: MDPKISYFQTFIVASKTKSFSKAAKRLGITQGTVSNHISALEKYFDAQLFLRTPEGVDLTPEGKIFYERAEKILDLLNEAKLLMRAIHENPEGIIRIYASTTPGEHILPSIIKEYKSSYKNVDFEITITDSERCFKALDEGLADIAAVGYLKNKNYEYTIIGKDRLVLIVPPNHPLAEKGTAKLEDILKEDYIDREEGSGTREAFIKALNDKGYSIMDLNVVMRLGSHSAVITAVSEGYGVSVVSEIPAKKAEDAGLIKIVPVVDLDVVRYLYLVKSRRPKNPSAVKSFWEFVTKV
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator MJ0300.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: TRUD_SALPA
Sequence: MTEFDNLTWLHGKPQGSGLLKANPEDFVVVEDLGFTPDGEGEHILLRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDFSAFQLEGCKVLEYARHKRKLRLGALKGNAFTLVLREISDRRDVETRLQAIRDGGVPNYFGAQRFGIGGSNLQGALRWAQSNAPVRDRNKRSFWLSAARSALFNQIVHQRLKKPDFNQVVDGDALQLAGRGSWFVATSEELPELQRRVDEKELMITASLPGSGEWGTQRAALAFEQDAIAQETVLQSLLLREKVEASRRAMLLYPQQLSWNWWDDVTVELRFWLPAGSFATSVVRELINTMGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: TTC1_MOUSE
Sequence: MEEKSEDCKVPEDLFNGLKVADPQEGESASPMVSDPKGQHCQSKLPKAAEAHPQDDHVEEECFHDCSASFEEEQPGAHVAGSKASDDSSSELDEEYLIELEKNMPEEEKQKRREESAKLKEEGNERFKRGDYMEAESSYSQALQMCPACFQKDRSVLFSNRAAARMKQDKKETAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSVLEKDPSVHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR
What are the official names of this protein?
Tetratricopeptide repeat protein 1, TPR repeat protein 1.
Protein: DAPB_VIBVU
Sequence: MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGLNDL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIN1_MOUSE
Sequence: MEDPGETGAHPLGATNLNFVPGHQQKEKPSTDPLYDTPDTRGVQAGGSQQPARTVSLRERLLITRPVWLQLRANAAAALHVLRTEPPGTFLVRKSNTRQCQALCVRLPEASGPSFVSSHYIEESTGGVSLEGSELMFQDLVQLICGYCRTRAIHQAATHKELEAISHLGMEFWSSSLNTKDQQRPSEAPPIPRLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGTSSSQTERLPPRQLLQRESSVGYRVPGSAASPCLPPLPSLQEVDCCSPSSSEEEGSSGSPTTSPRLSRPRHRRPLLRSMSSAFCSLLAPERQVGRAATMLMQNRYTAVGQLVQDLLTQVRAGPEPRELQGIRQALSRARAMLSAELGPEKLLPPERLELVLEKSLHRSVLKPLRPILAARLRRRLSADGSLGRLAEGFRLARTQGPGAFGSHLTLSSPVETEQVRQKLLQLLRAYSPSAQVKWLLQACKLLYTALKSQAGENAGADEFLPLLSLVLAQCDLPDLLLEAEYMSELLEPTLLTGEGGYYLTSLSASLALLSGLSQARALPLSPAQELQRSLALWEQRRLPATHSFQHLLRVAYQDPSTGCTSKTLAVPPGSSIATLSQLCATKFRVTQPDAFGLFLYKDQGYHRLPPEALAHRLPATGYLIYRRAERPETQGAVAEKAKTGSKGPEAGAWEEETGGLNREGKPRIAVDQEGKDQARGGHIGPEEQKAEGSQALEE
What is the function of this protein?
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation.  Can affect Ras signaling at different levels.  First, by competing with RAF1 protein for binding to activated Ras.  Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling.  Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity).
What are the official names of this protein?
Ras and Rab interactor 1, Ras interaction/interference protein 1.
What is the protein family that this protein belongs to?
Belongs to the RIN (Ras interaction/interference) family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane- associated.
Protein: CCME_BRUA1
Sequence: MSATAEQNARNPKGKGGFARTVSQRKRKRLFLIGGALAVLAVAVGLMLTAFNQDIRFFRTPADLTEQDMTSGARFRLGGLVEEGSVSRTGSELRFTVTDTIKTVKVVFEGIPPDLFREGQGVVAEGRFGSDGLFRADNVLAKHDENYVPKDLADSLKKKGVWEGK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: PSAL_CROS5
Sequence: MDIIGQRGDPQIGNLATPVNSSRLSLAFIRNLPAYRRGLSANRRGLEVGMAHGYFLYGPFAILGPLRNTEYASTGGLLSAVAMISILTIALSLYASVEVGKPIETLTTPDVPEDLGTSVGWGEFANGFFIGGSGGVIFAYLLCQALYFDLIQKILG
What are the official names of this protein?
Photosystem I reaction center subunit XI, PSI subunit V, PSI-L.
What is the protein family that this protein belongs to?
Belongs to the PsaL family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: CEDA_ECOL5
Sequence: MKKPLRQQNRQIISYVPRTEPAPPEHAIKMDSFRDVWMLRGKYVAFVLMGESFLRSPAFTVPESAQRWANQIRQENEVEE
What is the function of this protein?
Activates the cell division inhibited by chromosomal DNA over-replication.
What are the official names of this protein?
Cell division activator CedA.
What is the protein family that this protein belongs to?
Belongs to the CedA family.
Protein: FRSA_SHISS
Sequence: MTQANLSETLFKPRFKHPETSTLVRRFNHGAQPPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWAIQAMVWQQKACAEEDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKAVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITGWIEKRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: MK12_MOUSE
Sequence: MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYFESLRDTEDEPKAQKYDDSFDDVDRTLEEWKRVTYKEVLSFKPPRQLGARVPKETAL
What is the function of this protein?
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.  MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2.  Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each.  Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets.  Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.  Phosphorylates DLG1.  Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes.  This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment.  Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure.  MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle.  C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation.  MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability.  MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
What are the official names of this protein?
Mitogen-activated protein kinase 12, MAP kinase 12, MAPK 12, Extracellular signal-regulated kinase 6, ERK-6, Mitogen-activated protein kinase p38 gamma, MAP kinase p38 gamma, Stress-activated protein kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma.
Protein: MIAA_ACIAD
Sequence: MSSTLPVINLMGPTASGKTALACELYERGHFELISVDSALIYKDMDIGTAKPTKEELALYPHHLIDIITPLEVYSAAQFVEDATQLIDQIHMKGKTPILVGGTMLYFKSLLEGLSTNLPSADAEVRAAIEKQAEQEGWQSVYDELARVDPVAGARFKVSDRQRIIRAIEVYRLTGQPITKLQAEQPKNVPYRYTFHNYALLPDRIELHKRIEQRLFKMWSIGFLNEVESLIKKYDLNDNLPSMRSVGYRQALDFLLKSDMSHNNRREMEDKALFATRQLAKRQYTWLRSLQETHYFKTYLTIKQAQEDLRNSYG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ISPF_PSET1
Sequence: MIRIGHGFDVHKFGGVGPLTIGGEKIDYPQGFLAHSDGDVAIHALCDAILGALAMGDIGKHFPDTASEYENIDSRILLRHVVSLAKEQGYVLGNGDVTIVAQAPKMLPHIQAMRSNLASDLNCELSQINVKATTTEKLGFEGRKEGISSHAVVIMNKESMSKTNA
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RR14_PINTH
Sequence: MARKSLIQREKKRQALERKYHLIRQSLEEKSKVSSLDDKWEIHRKLQSSPRNSAPTRLHRRCSSTGRPRANYRDFGLSGHILREMAHACLLPGIKKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATG7_MOUSE
Sequence: MGDPGLAKLQFAPFNSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPTRLTLEFSAFDMSASTPAHCCPAMGTLHNTNTLEAFKTADKKLLLEQSANEIWEAIKSGAALENPMLLNKFLLLTFADLKKYHFYYWFCCPALCLPESIPLIRGPVSLDQRLSPKQIQALEHAYDDLCRAEGVTALPYFLFKYDDDTVLVSLLKHYSDFFQGQRTKITVGVYDPCNLAQYPGWPLRNFLVLAAHRWSGSFQSVEVLCFRDRTMQGARDVTHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSGCMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHVTFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAAERLQKIFPGVNARGFNMSIPMPGHPVNFSDVTMEQARRDVEQLEQLIDNHDVIFLLMDTRESRWLPTVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPSHLVAPADLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSPKVLDQYEREGFTFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDEETV
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (By similarity).  Required for autophagic death induced by caspase-8 inhibition.  Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.  Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.  Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (PubMed:29937374).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, APG7-like, mAGP7, Ubiquitin-activating enzyme E1-like protein.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
Protein: FENR_NITWN
Sequence: MSEAIKTDVLIIGAGPCGLFAVFELGLLDMKVHLVDILDKIGGQCAELYPEKPIYDIPGIPLVTGQGLTEALLEQIKPFNPTFHLNEMVESIEKIGDPGFRVTTDAGQVFECKVVVVSAGGGSFQPKRPPVPGIEAYENISVFYAVRKMEQFRDKEILIVGGGDSALDWTLNLHPLAKRITLLHRRDEFRAAPHSVEQMRKLVADGTMDLKIGQVTALEGADGKLTGAQVKGSDNTTSTVSCDTMLPFFGLTMKLGPVANWGLHLENNLIPVETASFETNVPGIFAIGDINTYPGKLKLILSGFHEGALMAQKAHRYVYPDKRLVFQYTTSSSSLQKKLGVN
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: SELU_SALCH
Sequence: MQDRQKAQDYRALLLADTPLIDVRAPIEFEQGAMPGAINLPLMMDDERAAVGTCYKRQGADAALALGHRLVCGDIRQQRLEAWKAAYQRFPNGYLCCARGGQRSHIVQRWLQETGIDCPLIEGGYKALRQTAIQATWQLAQKPILLIGGCTGSGKTQLVRQQPNGVDLEGLARHRGSSFGRTLNPQLSQASFENKLAVELLKINARQTLKRWVLEDEGRTIGANHLPECLRERMAQAPIAVVEDPFALRLERLREEYFIRMHHDFTHAYGDEAGWQAYSEYLHHGLFAIRRRLGLQRFAELTDTLDRALAEQLSSGSTDGHMAWLVPLLNEYYDPMYRYQLEKKAANIVFRGPWQDVANWLKAQ
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: NRDR_CORGL
Sequence: MYCPFCQHDHSKVIDSRVIDAGSAIRRRRECSKCEGRFTTIEKAVLLVVKRNGVTEPFSREKVVTGVRRACQGRDVSDDALKRLAQQVEETVRSNGSSQVRANDIGLAILDPLRELDEVAYLRFASVYKSFDSADDFEKEIRLMRRRGRD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.