Protein: ECHPS_ASPRC
Sequence: MGSIESDSVLSFFSQRCCQNPDNTAIDDGPNGKLSYSQLDQQSSALAYCLQQNGITAGQVIPLLTTSRLEMVIAVLGILKAGGVYVPIDVDQWPADRINYVLSRTCSGLVVYTGDNIPSGVSLEEECRTVQVQIWPESALETQYEPNRRPQLMCIIFTSGTTDKPKGVMIPHSSVARFVTSPGFNYDIVPGDRLLLVLSVAFDGMGTLFNTICNGGTVILANRLNFQERSRQCTVLVVTPSILDVLSPPQSPSDYPSLERIFLGGETPSQQLLEAWSAFNDVALWIAYGPTEATCAVLSGRLQASSETGKFHPTRLGHCIPGSNVLLLTEEMETVQDRDTEGEICIEGPCLTDGYWQDENRTKDRFIEYQGRRVYRTGDLGRFVTTEDSETAIEFCGRRDRVTKIRGFLVNLELDVDAGLRRLDQNITAVFSVVLDKKLCTAVVPSSVDCRHLQAAWRLVAPPYLVPDKMVALNDLPLTANGKFDPRQVISILRDVMQKDAIMQNSISHDNPDANNRKQYSWHSGPLTIGQAILIGIQQVLGVSQGEINLKDSAVFQGVHSLAAAKLSTFCRHHGYNVSVESILTEPSLHSLIEKSRHETEDTPDSSAFATRTPEESSMPTQGPVTPLQKRMVLDSIVEDPRANCLQHISWYKMEDIGRLREAWKMVVTHEPVFQTSFELDDTQEPSQRLIGAGIFIWEETTVTTYAAIEESLKSLPAATGLGSRFRVLHCVGPEFPRSESIFVWAVHHALIDGYSASLVFEKVDKALKDEPFESSHPFTLAAQDIAQMRDKIAPEVDHFWKDQETQYPGAAGEPLIPEALTDQSGMDFAEHVANVSIDSQRLRFAAQQAQATPAAIFYAAWALLLSSYTNSDTVIFGAVFSGRNLPFSWAPCMVGPLLNILPLRCRIEREVESASFVREIHQTIQDISRFQVADRPKNTPPFASTLTVQDSGLRSGTTAISSLRNPEVRESNLLPLTVVVENDGQITFLYRTDRFSESHVKDMAAIYTSLLDAFLDPGRNLQDCMNRRFPIEMNRTILQTGNIDSEISRVPSVNGGHTLSSLFGMVASLYPTHVAVQKGPHSVTYATLVQCAARVAAVVEQKTQPGEVVAILADRSINWIVGIMGATIANTVYCPLDSSYPAEYREDLLRRSHAKLFLVPSRSQLPTADNGVTAISIEGILASDIEPLCPWRTQKPSDGAYICFTSGSTGVPKGVLCQHQGVVSLQSCSIEGRLHSKPGRRIAQFMSTGFDVCVHEVFASLCYGGTLVLRKDDDDPFSHLADVDVVSMNATVAGSLDPSEYSDLDYVYLAGEPIPQRTADKWAVDRELYNAYGPTEATIIVTRTRLEAGVPVAIGQPFPSVRAYILNDHRELQPPNTLGNLFVAGVQVSHGYLDLPEVTAKSYFPDPFLPESFNERMYDTGDIGFWDTDGKIQCCGRKDRQVKVRGFRINLDGISNMATLRMPTIRHAAAFVKDGGVVLCVEPEDVDTGELRSRLKDALPPHAIPRTIYSIAHIPLSLNGKIDVKSLAAMEVRNGTVPTNGVIKTTHLEKLIAQEWQQLLGLDPAQPLSRSDDFVLLGGDSIRQLNLAARLRSVLGLPIKVKDIIRSSTLGDLVILVAQQQEQHGKKNAPNGAPAHSIVDRPLGFKNLSPPEMEWACKYRHSQSQSTFNVSYVARLSPAVDWQRLASAFETVLNRHRVLRSRFAVRRDGSNERVLSEYPISVKRTVHDVNIQEVINQPFEIDSSEALIHTIVSPSTLVLCISHILCDLTSINTLLYEVADTYHGLTLSPVVREYFDVTWHHTVDQEKQRFWAEYLEGLSFKKPNLASQIREPRSYRGTSRTTSLSDSLYRRLIISSTKNGFTFHQFGMAVAGLVLHFLTGRDDIVLGSPFVNRPSFEDRQVIGLFLEPLPVRISVKHQNENNGGPDAREFVQSVRQSSQSALAHSVPWSELMSHLGLPFPSAQPQLFSCCVTFHDDRGTEPPLAIQGVEGQYVSAEGAKFPLLFEWQATRASEHEQLTVRLEYDTDWLSAEFVEILEALLLECFRILLEEEDSHHGEVKERLGEVLRSEATRIGVGVNEICEMARQHLMVV
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of echinulin family alkaloid (PubMed:29072465, PubMed:33381959).  The pathway begins with the biosynthesis of the cyclic dipeptide cyclo-L-Trp-L-Ala (cyclo-TA) by the NRPS echPS via condensation of L-alanine and L-tryptophan (By similarity).  The prenyltransferase echPT1 then catalyzes the first prenylation step, a reverse prenylation reaction at C2, to yield preechinulin (PubMed:33381959).  Preechinulin is the substrate of the cytochrome P450 monooxygenase echP450 that catalyzes the formation of the double bond between C10 and C11 to produce neoechulin A (PubMed:33381959).  The unique prenyltransferase echPT2 functions as a competitive enzyme with echP450 for preechinulin metabolization and uses preechinulin for effective regiospecific prenylations.  Preechinulin is prenylated by echPT2 at C5 or C7.  C7-prenylation leads to accumulation of tardioxopiperazine B without further modification by echPT2.  In contrast, the C5-prenylated tardioxopiperazine A can be prenylated again by echPT2, predominantly at C7 to form echinulin or less frequently at C4 to give variecolorin L.  EchPT2 accepts also neoechilunin A to produce varlecolorin G (prenylation at C5) or isoechinulin A (prenylation at C7).  EchPT2 further converts isoechinulin A into dehydroechinulin.  Moreover, a yet unidentified enzyme can also convert neoechilunin A into neoechilunin B by introducing a double bond between positions C14 and C17 and thus provides a further substrate to echPT2 for C5 and C7 prenylation (PubMed:33381959).
What are the official names of this protein?
Nonribosomal peptide synthetase echPS, NRPS echPS, Echinulin biosynthesis cluster protein echPS, Echinulin pepdite synthetase, EchPS.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.