PharMolix/UniProtQA huggingface dataset:
Protein: RS3_DEIRA
Sequence: MGNKINPNGFRLGVTKGWNSRWYAGKKQYASLLKEDEQIRQLINKKLAAAGIARIEIERAGQQVNVIISAAKPGVVIGKGGESIKELRGDIERLVSAGTVAVNVAEIPNPNISAPLVALRIAEQIERRFAFRRAMKQAAQRVMESGARGVKVILSGRLGGAEQARTEKVLEGRVPLHTLRADIDYGTALARTTYGILGIKVLVFNGEVIGGKTETFARPQRRDRDERRPEGGDRPARRRPTARRRTGGE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CYC_ASTRU
Sequence: MGQVEKGKKIFVQRCAQCHTVEKAGKHKTGPNLNGILGRKTGQAAGFSYTDANRNKGITWKNETLFEYLENPKKYIPGTKMVFAGLKKQKERQDLIAYLEAATK
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: AROB_FRATN
Sequence: MISKLSVSPTFSPSYNIIVDSVLDFSHILEYVTNKQVLIVTNTTVAKLYLTKFLAALVDDLDVNTCILEDGEQYKSQQSLDKILSTLLENNFTRNSTVLVALGGGVIGDITGFAAAIYQRGVDFIQIPTTLLSQVDSSVGGKTAINHQLGKNMIGAFYQPKVVYTSIEFYKTLPQREYIAGMAEVVKYAFISKDFYLWLDSNRDKILAKDSVTLIEMVKRSCQIKAQVVAMDEKELTGARAILNFGHTFGHAIEKCQNYRGLKHGEAVGVGMAQAIDFSHYLGLISQQQAKDFKDFIVSFGISIDFPKDICQKEFLEAMLLDKKNSNKELKFILIENIGSLSLQKQSKNELEQFLDISR
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCR_STRRM
Sequence: MDVLGAAALALFLVPLLIVAEQGRTWGWGSPAALALFALGAAGLAVFIPVELRRGDEAILPLGLFRRGSIALCSAVNFTIGVGIFGTVTTLPLFLQMVQGRTPTQAGLVVIPFMLGTIASQMVSGKLIASSGRFKKLAIVGLGSMAGALLAMATTGATTPMWGIVLIVLWLGVGIGLSQTVITSPMQNSAPKSQLGVANGASACAGQIGGSTGIAVLFSVMFAVALGRLADLLHTPRYERLLTDPAITGDPANHRFLDMAESGQGAGINLDDTSLLNGIDARLMQPVTDSFAHGFHIMFLPGGVVLLAGFVMTWFLRELQEETAPEEERPAESGAGAKNGPLPASDA
What is the function of this protein?
Resistance to tetracycline by an active tetracycline efflux.  This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells.  This protein functions as a metal-tetracycline/H(+) antiporter.
What are the official names of this protein?
Tetracycline resistance determinant, TET347.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PAKC_DICDI
Sequence: MISLDLSPTLWKSPDKEGELKKQGHVVKNWKKRKFIIQNDMLFYFKDKEERPVGAVPLRMSRCYENKSLGKPNCFELVSPRINKTFFIQANTPDEMASWMKAVEKGSEYSTVSQPFNLKHEVHVDFNSATGFSGLPKEWEVILKSSNVSKQEVLDKPSEWLSVLEFQAGRTMEKSNSQNLSALPDESNLTLSDLVTKEDPTKIYKNMTKIGEGAAGEVFVATSSKNNKRVAIKKIEINNDNAKLLVTEIAIMKTSHHDNIVNYIDSYIVNDRELWVAMEFMGGGCLTDILEAFDNIKMSEIQIAYVVKETLKALQYIHSLHRIHRDIKSDNILLGSEGSVKIADFGYAAQLTQKQQKRNTVVGTPYWMAPELIRGHDYGVKVDIWSLGIMMMEMAEGEPPYMDFPPLRALFLITTKGIPPLKETTKWSKTFQDFFSKCLDINVANRPDATDLLKHPFMDLACDSSEFKPLIQAARNV
What is the function of this protein?
Has role in the regulation of chemotaxis.
What are the official names of this protein?
Serine/threonine-protein kinase pakC, dPAKc.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Cytosolic in unstimulated cells, localizes to the plasma membrane in response to chemoattractant stimulation with kinetics consistent with those of kinase activation, where it binds to phospholipids via its PH domain.
Protein: OBG2_ANAMM
Sequence: MSFRREKFIEFGGPDGGNGGNGGSVIFVASSAVNTLLYFRYNQHIRAENGKAGSGKGKFGAAGRNRVVEVPVGTQLYDEDGNTLIADLNNIGQQYTVAAGGRGGIGNAQYKSSTNRAPTYFTYGTLGEEHCVLLKLKIVSDVGIIGMPNAGKSSLLSRCTASKTKVSDYPFTTLEPHLGVAYANGCELVLADIPGLIENASSGAGLGHKFLKHIERCVILLHLVDCSLPDIVSAYELVRQELKLHSQELAGKQEVVILNKCDLLSEGEVREKQKLLESSTKKEVITLSMGDELDSLIVFLHAQVKKAVVTEPSDTSFDPFLYVHYNKK
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg 2, GTP-binding protein Obg 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPIKE_ADE02
Sequence: MKRARPSEDTFNPVYPYDTETGPPTVPFLTPPFVSPNGFQESPPGVLSLRVSEPLDTSHGMLALKMGSGLTLDKAGNLTSQNVTTVTQPLKKTKSNISLDTSAPLTITSGALTVATTAPLIVTSGALSVQSQAPLTVQDSKLSIATKGPITVSDGKLALQTSAPLSGSDSDTLTVTASPPLTTATGSLGINMEDPIYVNNGKIGIKISGPLQVAQNSDTLTVVTGPGVTVEQNSLRTKVAGAIGYDSSNNMEIKTGGGMRINNNLLILDVDYPFDAQTKLRLKLGQGPLYINASHNLDINYNRGLYLFNASNNTKKLEVSIKKSSGLNFDNTAIAINAGKGLEFDTNTSESPDINPIKTKIGSGIDYNENGAMITKLGAGLSFDNSGAITIGNKNDDKLTLWTTPDPSPNCRIHSDNDCKFTLVLTKCGSQVLATVAALAVSGDLSSMTGTVASVSIFLRFDQNGVLMENSSLKKHYWNFRNGNSTNANPYTNAVGFMPNLLAYPKTQSQTAKNNIVSQVYLHGDKTKPMILTITLNGTSESTETSEVSTYSMSFTWSWESGKYTTETFATNSYTFSYIAQE
What is the function of this protein?
Forms spikes that protrude from each vertex of the icosahedral capsid.  Interacts with host coxsackievirus and adenovirus receptor CXADR located at the cell tight junctions to provide virion initial attachment to target cell.  The fiber protein binds to CXADR with a higher affinity than CXADR binds to itself, thereby blocking the cell-cell adhesion function of CXADR dimers and leading to local disruption of the tight junction.  Fiber protein present on neo-synthesized particles may thus disrupt the junctional integrity in order to facilitate further neighboring cells infection.  Fiber proteins are shed during virus entry, when virus is still at the cell surface.  Fiber shedding is dependent on viral CXADR drifting motion and subsequent binding to immobile integrins.  Heparan sulfate might also play a role in virus binding.
What are the official names of this protein?
Fiber protein, SPIKE, Protein IV.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae fiber family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Anchored to the pentons, protrudes from the virion surface. Present in 36 copies per virion.
Protein: RNH2_NOCFA
Sequence: MTARTGWPPRMVMRKAGGLRTLEAALIRGGLGPVAGVDEAGRGPCAGPLVVAACLLAPKAYDRLAGLDDSKKLTEAAREELYPVITRLALAWEVVVIPAWEIDAIGIHVANIEGMRRAVAGLRQRPGYVLTDGFRVPGLAAPSLPVIGGDAAAACIAAASILAKVTRDRIMVELDSRHPGYGFAAHKGYNTPEHTAALQRLGPCSEHRRSWRNVRERLGLRPLDPTVEYAETVLADGVADSRVAADAAHAG
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_METEP
Sequence: MAPKPDPGRRVVADNRSARYHYAIEDTLEAGIALTGTEVKSLRGGKATIGESYAGPSGNDLMLFNAYIPEYLEANRFNHDTKRPRRLLLHRRQINKLIGATQRQGYTVIPLKIYFNDKGRAKVELGLGKGKQLHDKRESVKQRDWDRDKARLMRDKG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RO60_XENLA
Sequence: MEATMDQTQPLNEKQVPNSEGCYVWQVSDMNRLRRFLCFGSEGGTYYIEEKKLGQENAEALLRLIEDGKGCEVVQEIKTFSQEGRAAKQEPTLFALAVCSQCSDIKTKQAAFRAVPEVCRIPTHLFTFIQFKKDLKEGMKCGMWGRALRKAVSDWYNTKDALNLAMAVTKYKQRNGWSHKDLLRLSHIKPANEGLTMVAKYVSKGWKEVQEAYKEKELSPETEKVLKYLEATERVKRTKDELEIIHLIDEYRLVREHLLTIHLKSKEIWKSLLQDMPLTALLRNLGKMTADSVLAPASSEVSSVCERLTNEKLLKKARIHPFHILVALETYKKGHGNRGKLRWIPDTSIVEALDNAFYKSFKLVEPTGKRFLLAIDVSASMNQRVLGSILNASVVAAAMCMLVARTEKDSHMVAFSDEMLPCPITVNMLLHEVVEKMSDITMGSTDCALPMLWAQKTNTAADIFIVFTDCETNVEDVHPATALKQYREKMGIPAKLIVCAMTSNGFSIADPDDRGMLDICGFDSGALDVIRNFTLDLI
What is the function of this protein?
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:15907467, PubMed:17041599).  May play roles in cilia formation and/or maintenance (By similarity).
What are the official names of this protein?
RNA-binding protein RO60, 60 kDa SS-A/Ro ribonucleoprotein, 60 kDa Ro protein, 60 kDa ribonucleoprotein Ro, RoRNP, TROVE domain family member 2.
What is the protein family that this protein belongs to?
Belongs to the Ro 60 kDa family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GDE_YEAST
Sequence: MNRSLLLRLSDTGEPITSCSYGKGVLTLPPIPLPKDAPKDQPLYTVKLLVSAGSPVARDGLVWTNCPPDHNTPFKRDKFYKKIIHSSFHEDDCIDLNVYAPGSYCFYLSFRNDNEKLETTRKYYFVALPMLYINDQFLPLNSIALQSVVSKWLGSDWEPILSKIAAKNYNMVHFTPLQERGESNSPYSIYDQLQFDQEHFKSPEDVKNLVEHIHRDLNMLSLTDIVFNHTANNSPWLVEHPEAGYNHITAPHLISAIELDQELLNFSRNLKSWGYPTELKNIEDLFKIMDGIKVHVLGSLKLWEYYAVNVQTALRDIKAHWNDESNESYSFPENIKDISSDFVKLASFVKDNVTEPNFGTLGERNSNRINVPKFIQLLKLINDGGSDDSESSLATAQNILNEVNLPLYREYDDDVSEILEQLFNRIKYLRLDDGGPKQGPVTVDVPLTEPYFTRFKGKDGTDYALANNGWIWNGNPLVDFASQNSRAYLRREVIVWGDCVKLRYGKSPEDSPYLWERMSKYIEMNAKIFDGFRIDNCHSTPIHVGEYFLDLARKYNPNLYVVAELFSGSETLDCLFVERLGISSLIREAMQAWSEEELSRLVHKHGGRPIGSYKFVPMDDFSYPADINLNEEHCFNDSNDNSIRCVSEIMIPKILTATPPHALFMDCTHDNETPFEKRTVEDTLPNAALVALCSSAIGSVYGYDEIFPHLLNLVTEKRHYDISTPTGSPSIGITKVKATLNSIRTSIGEKAYDIEDSEMHVHHQGQYITFHRMDVKSGKGWYLIARMKFSDNDDPNETLPPVVLNQSTCSLRFSYALERVGDEIPNDDKFIKGIPTKLKELEGFDISYDDSKKISTIKLPNEFPQGSIAIFETQQNGVDESLDHFIRSGALKATSSLTLESINSVLYRSEPEEYDVSAGEGGAYIIPNFGKPVYCGLQGWVSVLRKIVFYNDLAHPLSANLRNGHWALDYTISRLNYYSDEAGINEVQNWLRSRFDRVKKLPSYLVPSYFALIIGILYGCCRLKAIQLMSRNIGKSTLFVQSLSMTSIQMVSRMKSTSILPGENVPSMAAGLPHFSVNYMRCWGRDVFISLRGMLLTTGRFDEAKAHILAFAKTLKHGLIPNLLDAGRNPRYNARDAAWFFLQAVQDYVYIVPDGEKILQEQVTRRFPLDDTYIPVDDPRAFSYSSTLEEIIYEILSRHAKGIKFREANAGPNLDRVMTDKGFNVEIHVDWSTGLIHGGSQYNCGTWMDKMGESEKAGSVGIPGTPRDGAAIEINGLLKSALRFVIELKNKGLFKFSDVETQDGGRIDFTEWNQLLQDNFEKRYYVPEDPSQDADYDVSAKLGVNRRGIYRDLYKSGKPYEDYQLRPNFAIAMTVAPELFVPEHAIKAITIADEVLRGPVGMRTLDPSDYNYRPYYNNGEDSDDFATSKGRNYHQGPEWVWLYGYFLRAFHHFHFKTSPRCQNAAKEKPSSYLYQQLYYRLKGHRKWIFESVWAGLTELTNKDGEVCNDSSPTQAWSSACLLDLFYDLWDAYEDDS
What is the function of this protein?
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
What are the official names of this protein?
Glycogen debranching enzyme, Glycogen debrancher.
What is the protein family that this protein belongs to?
Belongs to the glycogen debranching enzyme family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: RS11_BIFLS
Sequence: MAAPKQAARKPRRRDRKSVPVGQAHIKSTFNNTIISITDPSGAVVSWASGGDVGFKGSRKSTPYAAGMAAESAARKAMEHGVKKVDVFVKGPGSGRETAIRSLQSAGLEVGSITDVTPQAHNGVRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: AROA_BACFN
Sequence: MRYLLSAPSQIKATIQLPASKSISNRALIIHALSKGDDVPSNLSDCDDTQVMIKALTEGNEVIDILAAGTAMRFLTAYLSSTPGIHTITGTERMQQRPIQILVNALRELGAHIEYVRNEGFPPLRIEGRELTGSEITLKGNVSSQYISALLMIGPVLKNGLQLRLTGEIVSRPYINLTLQLMKDFGASASWTSDQNIQVDPQPYHCLPFTVESDWSAASYWYQIAALSPQADIELTGLFRHSYQGDSRGAEVFARLGVATEYTETGIRLKKNGTCVERLDEDFVDIPDLAQTFVVTCALLNVPFRFTGLQSLKIKETDRIEALKTEMKKLGYILHDKNDSILSWDGERVEQQTCPVIKTYEDHRMAMAFAPAAIHYPTIQIDEPQVVSKSYPGYWDDLRKAGFGIKVGEE
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F106A_HUMAN
Sequence: MLPSTMFLVHLPLSTNRLHCLRNTSLESYLCSFVHLNHPLHISDRVILISLHEAVRFSFAFSFPRGTLSIAYCLMSSVSTSSEAIMSTELLANYCHSSLHVCICISSFPNETGNHDSFPGAVVSISDQPTDQCKLAAKELPLRNLLECRFFDCMGEEDLINLGVIGTER
What are the official names of this protein?
Protein FAM106A.
What is the protein family that this protein belongs to?
Belongs to the FAM106 family.
Protein: 5FCL_MYCS2
Sequence: MSPRSKSQLRTALLQNRRSVPEAVREGEAEALRGWLSGLKISGRTVCAYVPVGSEPGSIALLDTLLELGARVLLPVARNDAAGIPLPLQWGKYRPGTLVAAEFGLREPPPPWLPAETIGEADVILVPALAVDRSGARLGRGAGFYDRTLHHAAATAQVIAVVRDDELLDEIPAEPHDVAMTHVLTPKRGIVALR
What is the function of this protein?
Involved in the removal of 5-formyltetrahydrofolate.  In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage.  5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy.  Catalyzes the irreversible ATP-dependent transformation of 5-formyltetrahydrofolate (5-CHO-THF) to form 5,10-methenyltetrahydrofolate (5,10-CH=THF).  The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT).
What are the official names of this protein?
5-formyltetrahydrofolate cyclo-ligase, 5-FCL, 5,10-methenyltetrahydrofolate synthetase, MTHFS.
What is the protein family that this protein belongs to?
Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
Protein: RPIA_SACD2
Sequence: MTQDELKQAVAQAALDYILPHLEDDMILGIGTGSTARLFIDLLAAHKGKFDGAVSSSEASSEQLKGHGIPVYDLNSVDSLPFYIDGADEANAQLHLIKGGGAALTREKIITAVADKFICIADASKDVDVLGKFPLPVEVIPMARAHVAREIVKLGGNPVHRQDCVTDNGCQILDVYDLAIHDAPALEAKLNNIAGVVTNGLFALRPADVLLLGTTNGVETRFAAKP
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: ENTS_ECOSM
Sequence: MNKQSWLLNLSLLKTHPAFRAVFLARFISIVSLGLLGVAVPVQIQMMTHSTWQVGLSVTLTGGAMFVGLMVGGVLADRYERKKVILLARGTCGIGFIGLCLNALLPEPSLLAIYLLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMIGGLLLATGGVAWNYGLAAAGTFITLLPLLSLPALPPPPQPREHPLKSLLAGFRFLLASPLVGGIALLGGLLTMASAVRVLYPALADNWQMSAAQIGFLYAAIPLGAAIGALTSGKLAHSARPGLLMLLSTLGSFLAIGLFGLMPMWILGVVCLALFGWLSAVSSLLQYTMLQTQTPEAMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLVELRRFRQTPPQMTASDS
What is the function of this protein?
Component of an export pathway for enterobactin.
What are the official names of this protein?
Enterobactin exporter EntS.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PRIO_MOUSE
Sequence: MANLGYWLLALFVTMWTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQPHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSSTVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (PubMed:12732622, PubMed:16492732, PubMed:19242475, PubMed:19568430).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to. vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: PYRR_STRZP
Sequence: MKTKEVVDELTVKRAITRITYEIIERNKDLNKIVLAGIKTRGVFIAHRIQERLKQLENLSVPVVELDTKPFRDDVKSGEDTSLVSVDVTDREVILVDDVLYTGRTIRAAIDNIVGHGRPARVSLAVLVDRGHRELPIRPDYVGKNIPTSRSEEIIVEMTELDDQDRVLITEEA
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: BECN2_MOUSE
Sequence: MSPALFLCQRCKEPLKLLQQQGGPLEVQHHANTPTEIPVSAESQVRTSGRPHSDGGRVSQGSALCTFTLLTSGGPDSEGGTTSQGNACCTFTLLGESASMRTMNTIQNTVLETFEILSDQKVVDHPLCVDCTDHLLMQLDDQLALLASDNQKYKSFQDRELLVSEEEREALHAELCAELSSLEQEEARLTQELEDLDGHHARVAAELRAAQAESKELYKQHEQHRVEYSVFKMEQLELMDQLSSVENQLTYALSQQYRLRQTNIFNATFTISDEGPLGVINNFRLGCLPGVRVGWTEISSAWGQTVLLLFSLSKIAGLQFQRYQLVPFGDHSYLKSLTGDGVLPLFSDGSHSVFLNNKFDCGMKAFLDCLQQFVEEIERDERCPCLPYRIHVKEGLMEDVWDSGECCSIRTHLNTEEEWSRALKFMLSDLKLILAWASLRFSRVQRP
What is the function of this protein?
Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover.  Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.
What are the official names of this protein?
Beclin-2.
What is the protein family that this protein belongs to?
Belongs to the beclin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPHB_COMSP
Sequence: MTIVHRRLALAIGDPHGIGPEIALKALRQLSANERSLIKVYGPWSALEQAAQICQMESLLQDLIHEEAGSLAQPAQWGEITPQAGLSTVQSATAAIRACENGEVDAVIACPHHETAIHRAGIAFSGYPSLLANVLGMNEDQVFLMLVGAGLRIVHVTLHESVRSALERLSPQLVVNAVQAAVQTCTLLGVPKPQVAVFGINPHASEGQLFGLEDSQITAPAVETLRKCGLAVDGPMGADMVLAQRKHDLYVAMLHDQGHIPIKLLAPNGASALSIGGRVVLSSVGHGSAMDIAGRGVADSTALLRTIALLGAQPG
What is the function of this protein?
Involved in the degradation of terephthalate (TPA) via the protocatechuate (PCA) 4,5-cleavage pathway.  Catalyzes the dehydrogenation of 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate (DCD) to yield protocatechuate (PCA).
What are the official names of this protein?
1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase, DCD dehydrogenase, Terephthalate dihydrodiol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
Protein: 3MGH_METAR
Sequence: MPVLPRDFYDRPTLEVARDLLGKTLVRQLPAGRVALRIVETEAYIGENDKACHASKGMTARNRVMFGQPGHAYVYLIYGMYNCLNLVTEKDGYPAAVLIRAGEPIEGEEIMSSLRPKARKHHEIASGPGKLCGAMSITRALNGADVCASGELYVEDGPAVKKIVACPRIGVDYAGEDALRPWRFYDKNSPCVSKRAPGDI
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: PDCD7_MOUSE
Sequence: MALPPFFAQSRQGPPPPQPPPSAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRAPAEASRGGGGGGAFFPVPPPPLPPPPPQCRPFPGPDAVERPRPPPPGPGPPWSPRWAEAPPPPDVLGDAALQRLRDRQWLEAVFGNPRRPGGLRTPRTPAGPSLGEVRARLRSALRLVRRLRSLGQSLREAEADGAAWASLHAQAAPLRAELAERLQPLRQAAYVGEARRRLERVRRRVRVRERARDRRLSGRRGAQRTEREQEIDRWRVKCVQEVEEKKRDEELKAAADGVLAEVRKKQSDTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFEHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERRRELEKKQRKEKEKLLLQKREIESKLFGDPDEFPLAHLLQPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGNSVPQGWVLPPLPSNDIWATAIQLH
What is the function of this protein?
Promotes apoptosis when overexpressed.
What are the official names of this protein?
Programmed cell death protein 7, ES18.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL29_SHEFN
Sequence: MKASELREKSVEELNAELLGLLREQFNLRMQHATGQLTQTNQLKLVRRNIARVKTIITSKAGV
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: SAM_RICPR
Sequence: MNDALKTYLNGICWFLLSLVTSSINDVMSKYLGTRLHSFEVAFFRFFFSSIVLLPFVVYYGKNALKTSRPFVHVLRGLLLFFGMTSWTYGLTIAPVTTATVVSFAIPLFTLILAVFILNENIIWQRWVVTVVGFIGLVVMLKPHTKDFNPEILYLILAAISFAMLDIINKKFVVKESMLSMLFYSAIVTAMVSLPVAMQYWITPSSFELALLFVLGSSGSFILFFLLKAFSIVDATATAPYRYLELVISAIAAYFIFNEFPDKSTVHGAVIIIPATLFIIYSEKKSMSSKHESQ
What is the function of this protein?
Transports S-adenosylmethionine.
What are the official names of this protein?
S-adenosylmethionine uptake transporter.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TSAC_NEIMF
Sequence: MLFPRIIAASAQRKLSVYLKKGGLVAYPTESCYGLGCLPTLAKALGKLAHLKKRPQHKGMIVIGNQFEQLQPLLQMPSENLQDMLRKEWPAPKTFLLSAKSCVLPELRGKQRSKLAVRVPAHVGARRLCQALQTPLVSTSCNRAGKRACRTEREVRRQFGRDVWIVGGRIGRQKSPSQIIDGETGKRLR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.