PharMolix/UniProtQA huggingface dataset:
Protein: TG21_PSHV1
Sequence: MELRVERVEKNYERRLAVRYHDETAGRIYVVYGGCIFSMRTVGRDMSITMFGYRLRSPVMCALVSTELLQNRRGRGEAAAEPSVGGAGSPGADYLFTHHLGSASGEAPEDLVNTFDVNVRGLVLSKLFVGFPVPDGIVLRLGEVDEGTGVLRILAKPRAVNSVTGFVYHLDSASLDLTQAELYEVPQFLAKDIEDLLRMGELRRSPLRLSIPRTPVIVTGNRGLSTITVPSSRGRGGDRRRRRRNVTKMAGHVQIKMFRDERDGQQTETDAGRAEEEARHISGWSGGDHCRVEPCEVSHLRVWKVVSLIEVALAVRKGPLSWLGLAHKNPTDNLRAVLKGEARDVCEKLGPWTEIMGKSVLRPGPEMIYATVNYLLELGGLQSKFCIMEDLCNKYAAKHNIDVPNEAPPSDEMALIEELAVSILQKAAVVCEVLRFAAKAESENIAAVRNVVAPKQYGAASELLVHETSFLLNSARGGAFLGPEDDGRAATTRPLFKRAMARTDKKVSAILACIYLESRPSRIVGTILGGEDLVRALEEARLRIVDPWDKDDISAALRVLDSIVNFRLA
What is the function of this protein?
May facilitate the viral transport through neural circuits.
What are the official names of this protein?
Tegument protein UL21.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae HHV-1 UL21 protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus.
Protein: RISB_ALKEH
Sequence: MNIIEGDFQNPGSARFAIVAARFNDFVVGHLVEGAADALRRHGVPDDHIDLIRVPGSFELPLAVQQTAEAGRYSAVIALGAVIRGGTPHFEYVASECTKGVAATMMDTGLPIAFGVLTVDTIEQAIERSGTKAGNKGAEAALSALEMVSLMKKLAE
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: GLCNE_HUMAN
Sequence: MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVKDVIRQQALSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIY
What is the function of this protein?
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids.  Plays an essential role in early development (By similarity).  Required for normal sialylation in hematopoietic cells.  Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
What are the official names of this protein?
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ROK (NagC/XylR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_BACP2
Sequence: MRKYEVMYIIRPTVDDEAKKAVIERFNNVLTSNGAEITGTKDWGKRRLAYEINDFREGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEV
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: GPMI_EHRCJ
Sequence: MTNHSVILCILDGWGNGENNQFNAIAQAYKPCWDNITLQYPKSHLITHGSSVGLPDGQIGNSEVGHVNLGSGRIVLQDLCKINNEIKYIKDNVYLLEFINKIKKNNGICHIAGLLSDGGVHSSYTHILDIINTLSDFQIQVAVHIFLDGRDTPPISATKYISILCEHIKHLNNINIATLSGRYYAMDRDNRLDRTTKAYNAIAFANAKRYEDPLTAVQDSYNLGITDEFILPCIIGNYQGMKPQDGFIMTNFRSDRVIQIIKMIIGDIKTDNHITLDNTIGMVKYSDKINIPCLFPNNNITNTLGEVIANNQLHQLRIAETEKYAHVTFFFNGGKEDMFENEDRIIIPSPSVATYNLTPEMSAEKVTDTIIEKIKLQKYSLIIVNYANADMVGHTGNIDATKQAITTIDQCLSKILNCIQNTNYVLVITSDHGNAEEMFDVKNNMPYTAHTLNPVPFIICNYNKKIRLKNGRLCDVAPTILEILNLAKPKEMTGVSLIEQV
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RM51_XENTR
Sequence: MWSVQQLLWGCRSLLTQGCRSFSLGSRDLRKMNFMPQPKNTDRWDHKRALYGVYDNIGILGDFKAHPRDLIIGPSWLRGWKGNELQRCIRKRQMVGPRMFYEDRENLNKRIRFLYKRFNRYGKHR
What are the official names of this protein?
39S ribosomal protein L51, mitochondrial, L51mt, MRP-L51.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL51 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AQP1_MOUSE
Sequence: MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
What are the official names of this protein?
Aquaporin-1, AQP-1, Aquaporin-CHIP, Delayed early response protein 2, DER2, Water channel protein for red blood cells and kidney proximal tubule.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABZ_VIBCM
Sequence: MMTLTTDKKTMNITEIQSLLPHRYPFLLIDRVTDYEEGKYLIGLKNVSVNEPQFTGHFPQLPVFPGVLILEAMAQATGLLAFKTFGAPKENELYYFASIDEAKFRKPVTPGDQLMIEVEFLKERRGIALFNGVAKVDGDVVCSAQLKCARREF
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AOX_AJECA
Sequence: MYPTSGCARVLMACPAPAMLRGPLLRPSTTAIRGLRGSPLLYHYAATSNSNMRYFSSTSRRWIKEFFAPPKETDHIVESVTTWKHPVFTEKQMKEIAIAHREAKNWSDWVALGTVRFLRWATDLATGYRHAAPGKQGVEVPEQFQMTERKWVIRFIFLETVAGVPGMVGGMLRHLRSLRRMKRDNGWIETLLEEAYNERMHLLSFLKLAQPGWFMRLMVLGAQGVFFNGFFISYLISPRTCHRFVGYLEEEAVMTYTHAIKDLESGKLPNWANQPAPDIAVAYWQMPEGKRTILDLLYYIRADEAKHREVNHTLANLKQGVDPNPYAAKYDNPEAPHPTKSAEIVKPTGWERDEVI
What is the function of this protein?
Catalyzes cyanide-resistant oxygen consumption.  May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures (By similarity).
What are the official names of this protein?
Alternative oxidase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the alternative oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Protein: GMPPB_HUMAN
Sequence: MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM
What is the function of this protein?
Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.
What are the official names of this protein?
Mannose-1-phosphate guanyltransferase beta, GDP-mannose pyrophosphorylase B, GTP-mannose-1-phosphate guanylyltransferase beta.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_CLONN
Sequence: MTKVILSGCSGKMGKMISQSVNNFEGLSIVAGIDKFKDESLKYPIFENITECDVNADVVLDFSRPDALDSLLSYSKDNNLPVVLCTTGYSKEQLDKIDEYSKIVPVFHSANMSIGINLINNILKDISAMLYENYDIEIIEKHHNQKVDAPSGTALLLGNTIKDSIKEDTVFNKGRNGIKKREKNEIGIHAIRGGSIVGEHEVIFAGAGEIIELKHTALSREVFAMGALKACEYMAGKNNGLYTMDDVIKSKN
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPS_YERPG
Sequence: MGKNNDWLNFEHLVKDKQIEALQPPSMYKVILNNDDYTPMEFVIDVLQKFFSYDIERATQLMLNVHYQGKAICGVFTAEVAETKVAHVNQYARENEHPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: GALAK_ARATH
Sequence: MSWPTDSELNSIKEAVAQMSGRDKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTQVQLRSAQFEGEVCFRVDEIQHPIGLANKNGASTPSPSKEKSIWGTYARGAVYALQSSKKNLKQGIIGYLSGSNGLDSSGLSSSAAVGVAYLLALENANELTVSPTENIEYDRLIENGYLGLRNGILDQSAILLSNYGCLTYMDCKTLDHELVQAPELEKPFRILLAFSGLRQALTTNPGYNLRVSECQEAAKVLLTASGNSELEPTLCNVEHAVYEAHKHELKPVLAKRAEHYFSENMRVIKGREAWASGNLEEFGKLISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGCCLAFVDAEKAEAAASYVKDEYEKAQPEFANNLNGGKPVLICEAGDAARVLL
What is the function of this protein?
Sugar-1-kinase with a strict substrate specificity for the alpha-anomeric configuration of D-galacturonic acid (D-GalA) and ATP.  Involved in the biosynthesis of UDP-galacturonic acid (UDP-GalA) from the salvaged GalA that is released during growth-dependent cell wall restructuring.
What are the official names of this protein?
Galacturonokinase, D-galacturonic acid-1-P kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family.
Protein: MINK1_RAT
Sequence: MGDPAPARQSDFIFLVALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLNSQKQQQQQQQQQQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNSPLAKTKPSSAGPEPPIPQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNTSSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPADFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEDEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEVSGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSQGQSPPTKDGGGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
What is the function of this protein?
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking.  Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons.  Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway.  Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1.  Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
What are the official names of this protein?
Misshapen-like kinase 1, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, Misshapen/NIK-related kinase, Mitogen-activated protein kinase kinase kinase kinase 6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Postsynaptic density. Cell projection, axon. Cell projection, dendrite.
Protein: ENO_SHEWM
Sequence: MAKIINVIGREIMDSRGNPTVEAEVHLEGGFNGMAAAPSGASTGSREALELRDGDKARYLGKGVLTAVANINGPIRDALMGKDATAQAELDQLMIDLDGTENKDKLGANAILAVSLAAAKAAAAFKGMPLYAHIAELNGTPGQFSMPVPMMNILNGGEHADNNVDIQEFMVQPVGAKTFREALRVGAEIFHSLKKVLQEKGLSTSVGDEGGFAPNLASNADALAMIKVAVEKAGYKLGEDVTLALDCAASEFYKDGQYDLTGEGKVFSANGFSDFLKSLTEEYPIASIEDGLDESDWEGWAYQTQIMGDKIQLVGDDLFVTNTKILKRGIDNNIANSILIKFNQIGSLTETLAAIRMAKEAGYTVVISHRSGETEDATIADLAVATSAGQIKTGSLCRSDRVAKYNQLLRIEEQLGEKAPYRGRSEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: HIS7_BACC1
Sequence: MRESSQIRETTETKIKLSLQLDDGKNVSVRTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKEALHSKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTHHKIEALFKAFGRALSEAVERNANITGVNSTKGML
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_ECO45
Sequence: MSKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKAMLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPRFTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGRGKSRPIVEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTH2_DROYA
Sequence: MAERDHYHTIDDPNVPCNFYDTVNLTGHTVFPNGSYDYYGTIVPAELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNICCPWRQVFNSEVDGCIIDHSDNRTWPDPPMLNITFRNDSTILVNMFAQFAIQSFRPCPKMFSLQPETSHWDDYLLFENGSMLRVDDQQLIRKNEFCMVPTYVNESDMFYTIHPANCDMQDDNSTVKIINAYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLVGLTVGYTSLCYVQLYQVDATGDACKVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQEKKRFLFYSLYSWGIAVVFLAFTYIAQELTNLPAYLKPGIGDGVYCWLDMSNWAAMIYFYGPILVIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLFVMKKKVKHLITNRCSSVRDGSNQRQSQYSTKTTSSSVANLSLHEKPSVEKPLVISSSVDPQKTTIFR
What is the function of this protein?
Involved in biological aging and stress response.  Essential for adult survival (By similarity).
What are the official names of this protein?
G-protein coupled receptor Mth2, Protein methuselah-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YENA1_YERET
Sequence: MDKYNNYSNVIKNKSSISPLLAAAAKIEPEITVLSSASKSNRSQYSQSLADTLLGLGYRSIFDIAKVSRQRFIKRHDESLLGNGAVIFDKAVSMANQVLQKYRKNRLEKSNSPLVPQTSSSTDASSESQTNKLPEYNQLFPEPWDNFCRPGAIEALDSPASYLLDLYKFIQSVELDGSNQARKLETRRADIPKLSLDNDALYKEVTALSIVNDVLSGSAREYIDQSGQADKAVNQILGDTHFPFTLPYSLPTQQINKGLGASNIELGTVIQRVDPQFSWNTTQEKYNQVLLAYTQLSSEQIALLSLPDVFTQNFLTQTELSAGYLSASTTEILAEKDLSRHGYIVKAADNIKGPTQLVEHSDASYDVIELTCTNQAKETITVKLRGENIITYQRTKARMVPFDNSSPFSRQLKLTFVAEDNPSLGNLDKGPYFANMDIYAAEWVRENVSSETMVSRPFLTMTYRIAIAKAGASLEELQPEADAFFINNFGLSAEDSSQLVKLVAFGDQTGSKAEEIESLLSCGENLPIVSPNVIFANPIFGSYFNDEPFPAPYHFGGVYINAHQRNAMTIIRAEGGREIQSLSNFRLERLNRFIRLQRWLDLPSHQLDLLLTSVMQADADNSQQEITEPVLKSLGLFRHLNLQYKITPEIFSSWLYQLTPFAVSGEIAFFDRIFNREQLFDQPFILDGGSFTYLDAKGSDAKSVKQLCAGLNISAVTFQFIAPLVQSALGLEAGTLVRSFEVVSSLYRLVSIPQTFGLSTEDGLILMNILTDEMGYLAKQPAFDDKQTQDKDFLSIILKMEALSAWLTKNNLTPASLALLLGVTRLAVVPTNNMVTFFKGIANGLSENVCLTTDDFQRQELEGADWWTLLSTNQVIDDMGLVLDIHPVWGKSDEEMLMEKIQSIGVSNDNNTLSIIVQILIQAKNAQENLLSQTISAEYGVERSVVPLQLRWLGSNVYSVLNQVLNNTPTDISSIVPKLSELTYSLLIYTQLINSLKLNKEFIFLRLTQPNWLGLTQPKLSTQLSLPEIYLITCYQDWVVNANKNEDSIHEYLEFANIKKTEAEKTLVDNSEKCAELLAEILAWDAGEILKAASLLGLNPPQATNVFEIDWIRRLQTLSEKTMISTEYLWQMGDLTENSEFSLKEGVGEAVMAALKAQGDSDNV
What is the function of this protein?
Part of an orally active toxin complex (TC) with strong insecticidal effects on larvae of the Coleoptera Costelytra zealandica, Acrossidius tasmania and Adoryphorus couloni and some Lepidoptera larvae (PubMed:21278295, PubMed:22158901).  The TC has an endochitinase activity (PubMed:21278295) (Probable).
What are the official names of this protein?
Toxin subunit YenA1.
What are the subcellular locations of this protein?
Secreted. Note=Secreted when grown at 25 degrees Celsius or less, but not when grown at 30 or 37 degrees Celsius.
Protein: NINE_BP82
Sequence: MATPLIRVMNGHIYKVPNRRKRKPELKPSEIPTLLGYTASLVDKKWLRLAARRNHG
What are the official names of this protein?
Protein ninE.
What is the protein family that this protein belongs to?
Belongs to the ninE family.
Protein: 3L24_DENPO
Sequence: RTCNKTFSDQSKICPPGENICYTKTWCDAFCSQRGKRVELGCAATCPKVKAGVEIKCCSTDNCNKFQFGKPR
What is the function of this protein?
Binds with high affinity to muscular (IC(50)=114 nM) and neuronal (alpha-7/CHRNA7) (IC(50)=58 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.  Competitive radioligand binding assays also demonstrate that this toxin competes with epibatidine binding to the Lymnea stagnalis acetylcholine-binding protein (Ls-AChBP) (IC(50)=4. 9 nM).
What are the official names of this protein?
Alpha-elapitoxin-Dpp2d, Alpha-EPTX-Dpp2d.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DNLJ_CLOBM
Sequence: MDNKLEKMKELVEELNQYAYEYYVLDNPSISDKEYDLKYDELVILEKKTEVTLPYSPTQRVGDKILGEFSKYTHKGRLWSLDKAQNMEQLIEWHNRNLKVIEQYNSMSEDKLPELRYIVTKKFDGLTVNCTYDENGILIKSATRGTGIIGEDITAQIKTIKTVPLKIKNNHIIEVHGEAIMTKTAFEEYNKAAQVPLKNLRNGAAGALRNLDIKETARRNLSAFFYDVGYNEGSEFKNYREMMNFIRNMGLPQDKYIKECTNMEEVEKEIEYIESIREELDYDIDGAVIVVDDIKTREILGYTIKFPKWAIAYKFEAKEITTRLLDVEWNVGRSGRVTPTALLEPVELGGVTVKRATLNNMDDIKRKNVKLGAKVLVRRSNDVIPEIMGVAEESLEESKEIQAPDRCPYCNSHLVQNGVHYYCENTLSCKPQMVKSIVHFASREAMNIAGFSEKTAEQLFEKLDIKSIADLYKIKKEELLTLEKFKDKKSQNLINAIQNSKNCDLASFIYALGIPNVGKKTANDLVMKFKTLESIKNTTIEQLVEVPDVGEIVAKSIYDFFEDEKIISNIEELLNLGVKPYYEEERIDENPFMDKTIVVTGSLNNYSRGEIKDKLQSLGAKVSSSVSKNTDYVLVGEKPGSKYEKAIELGVKVINEEEFSNKIK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: LEPA_HYDS0
Sequence: MENIRNFSIIAHVDHGKSTLADRLIEFCGAITDREKKDQMLDTLDIERERGITIKLQAVKINYHSKIQNKDFTLHLIDTPGHVDFSYEVSRSLAACEGALLLIDASQGIEAQTVANFWKAVEQNLVIIPVINKIDLPAADPDRIKLQIRDILGLDPDEAILASAKEGIGIEEILEAITKRIPPPKGDENAPLKALIFDSYYDPYRGAVAFVRIFDGSLKVGDRIKLFSTGKEFEVTEVGAQTPKMTKLPILKAGDVGYIAASIKDVRDIRVGDTITLKSNPTKEAIPGFKTAKPMVFAGLYPTEDSDFEELRDALEKYSINDAAITYEPETSPAIGMGFRCGFLGLLHMEIVQERLSREYNIDVITTAPSVVYRLKLKNRSDILEVKSSNDIPDNFGLIEYIEEPYVLATIITPKDYVGNIINICQDKRGIQVKFSYLDQNTALLEYEMPLQEIIVDFHDKIKSASKGYASFDYEFLGYKESDLVKLTIMINKEPVDALSFLVHKDKAYRKARALVEQLKETIPRQLFEINVQAAIGSKIIASERIPPMRANVTAKCYGGDISRKRKLLEKQKEGKKRMKQFGKVSLPQEAFLSVLKAQ
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CMOB_ECOLC
Sequence: MIDFGNFYSLIAKNHLSHWLETLPAQIANWQREQQHGLFKQWSNAVEFLPEIKPYRLDLLHSVTAESEEPLSAGQIKRIETLMRNLMPWRKGPFSLYGVNIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSALALKNWLKKCGFVDIRIADVSVTTTEEQRRTEWMVTESLADFLDPHDPSKTVEGYPAPKRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.