PharMolix/UniProtQA huggingface dataset:
Protein: MCM5_HUMAN
Sequence: MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGEIQHRMQRKVLYRLK
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:16899510).  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425).
What are the official names of this protein?
DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytosol. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: TILS_NITEU
Sequence: MADSKSISPTDITDCFFHNLRAQVRPGDRLTVALSGGVDSVVLLHLLTTFSESMQLEVSAVHVEHGISTYSGEWSAFCQSLCDSLAIPLSIHRLKIRRRPQESLEAIAREARYQIFKHIQADYVMLAQHQDDQVETLILQLLRGAGVKGLSAMPTVRLLEPGKTIRLFRPLLNIPRSEILNYARLHGLSWVTDESNLDTSYDRNFLRHQILPLLEQRSPAYRKTLFRSTQHLGEAAHLLDELAEIDAENTLVTNRLSLQGLRKLEPARARNLLRYLLAQRLIRLPNSTKLEEILRQLNNIQPDNHFRFIVDTLEIRCHRGLIEFLPADSLPEPIAPVVWQGEQHLVIESLQGVLKFTRQNNMGIDPARLSGQIVTIRSRSGGERFQPDCKRPRRSLKKILQEAALAPWVRNTLPLLFCEDQLVWVAGIGIDCNFQISEGSTGLVVAWHPSQINQVSTH
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEX6_ASHGO
Sequence: MVIANLVFSASGTSLASVSRELYCTLFGPAPDELKHEFYVSVQLPSYSRHAKTYVVQSTLNETLEGQVVQLPSKIEDVPLDTPLIDLCKVEAVRERPPVLESVTIEVHGSLYEELTKLSEEDQLRFLQIRGDLRDCGTVVRAGQKLFVPWCQILDCVPYYQGLIDLQRTRILLLKGTDAMESCHLRKGLEDLKLRPNEGPTKELRIMLRCLEQPIERALLVPAADTDDDDSLFVFASAAVLLRLGVTSGARVTLSDGATSRIAKVFVLLSPNHFDSDAIYATPRLVVNFAEADKVVVSKYEGEMAELPVASSVSISRVGSWENSQMVYQKIILNNLTNFITAKQRIFYKDDLVPVTFDSDFSAMFSDQLNEFSVDYHDDSLVWFKIDTVKLNDDIPCEGAFRIDSKVTKLVTCNVSSSPPPPLSKCDYVSYYGLEPCFGYDRRVFDYAKRFHDIITTSRKCFQHGMNVGTTVMLHSSSVSVGKTTLVRSTCRELGIHLIEIDLLQLDPHMNSSNSTVNIVALIRAKIENVLPHTAPSVVYLAHLEGVLEKEDQISDPASLKAAKSMGIELAKLFTDYTELYPGTVFVCSTDALDVVPEAIRSKTKFEIEVPVPTETQRVEIFSWYLSPDVLNFNASQQFAMDHDVTISRLALQSAGLTPIDIRSIVESAKVCCYQRSKEKQHMLWQGGYRYINSADLSAAINKARDEFSDSIGAPKIPNVFWEDIGGLEMVKGEILDTIDMPLKFPELFASGMKKRSGILFYGPPGTGKTLLAKAVATNFSLNFFSVKGPELLNMYIGESEANVRRVFQRARDAKPCVIFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGLSTGGDGLFVIGATNRPDLLDEALLRPGRFDKLLYLGISDTNEKQANILRALTRKFTLDPDVSLDDLAASCPFTYTGADFYALCSDAMLNAMTRIAGNVDEKVASYNRAHNKNYSVRQWFDVIATAEDTSITVCMQDFVKAQRELVPSVSEGELNHYLAIRDNFESS
What is the function of this protein?
Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling.  Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel.  Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
What are the official names of this protein?
Peroxisomal ATPase PEX6, Peroxin-6, Peroxisomal biogenesis factor 6.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: T3HPD_STAND
Sequence: MRSSKVIHVVGCHAEGEVGDVIVGGVAPPPGETVWAQSRFVASDNTLRNFVLQEPRGGVFRHVNLLVPPKNKEAVAAWIIMEPEDTPPMSGSNSICVSTVLLDTGIVPMVEPETHMVLEAPGGLIEATAYCKNGKAERIRVKNHPSFADKLDAKLELEGYGTLTVDTAYGGDSFCIVDAHALGFSIKPDEAKDFADLGMKIVKAANQQLGFQHPTNKDWSHISFCQFAAPLTDDNGTPSGANAVAIRPGKIDRSPCGTGCSARMAVLHAKGILKVGDAFVGRSIIGSRFDCRVEAETSIGGRPAIVPSIMGRAFITHTAQLMVDPDDPWQTGYRLSDTWPVWKQD
What is the function of this protein?
Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C).  May be involved in a degradation pathway that converts t3LHyp to L-proline, which would allow S. novella to grow on t3LHyp as a sole carbon source.
What are the official names of this protein?
Trans-3-hydroxy-L-proline dehydratase, T3LHyp dehydratase, t3HypD.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: PNP_YERPS
Sequence: MLTPIIRKFQYGQHTVTIETGMMARQATAAVMVSMDDTAVFVTVVGQKKAKPGQSFFPLTVNYQERTYAAGRIPGSFFRREGRPSEGETLTSRLIDRPIRPLFPDSFLNEVQVIATVVSVNPQINPDIVALIGASAALSLSGIPFNGPIGAARVGFINDQYVLNPTTDELKESRLDLVVAGTAGAVLMVESEADILSEEQMLGAVVFGHEQQQVVIENINALVAEAGKPKWDWQAEPVNEALHARVAELAEARLGDAYRITEKQERYTQVDAIKADVTEALLAQDDTLDAAEIQDILASVEKNVVRSRVLRGEPRIDGREKDMIRGLDVRTGILPRTHGSALFTRGETQALVTATLGTARDAQNIDELMGERTDSFLLHYNFPPYCVGETGMVGSPKRREIGHGRLAKRGVLAVMPSASEFPYTIRVVSEITESNGSSSMASVCGASLALMDAGVPIKAAVAGIAMGLVKEGDNFVVLSDILGDEDHLGDMDFKVAGSRDGVTALQMDIKIEGITREIMQVALNQAKGARLHILGVMEQAISTPRGDISEFAPRIYTMKINPEKIKDVIGKGGSVIRALTDETGTTIEIEDDGTIKIAATDGDKAKHAIRRIEEITAEIEVGRIYAGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVTDYLQMGQDVPVKVMEVDRQGRIRLSIKEATTPDAEAPEAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_SOLM1
Sequence: MSQPDKVLILDFGSQYTQLIARRVREAGVYSEIHPCTVTAKEVAAMAPKAVILSGGPSSVADADAPPFDPAVFDLGLPMLCICYGMQLLAHHLPGGQVAASTDREYGRADLQLLADTPLFAGLPQKDGHIVWMSHGDKVMAAPDGFVVAARTKNVDIAALANASRRIYALQFHPEVAHTEDGERILHNFLFEIAGLTSGWTMSSFLETELASLKEKVGDDEVVCALSGGVDSTVVAVMLHKAIGKKLHCIFVDNGLLRMGEGEEVAAYLREHFDLNLHYVDAAKLFLDKLAGVTDPEEKRKIIGKTFIEVFEVEAAKLPKVKYLAQGTLYPDVIESVSFKGPSAVIKSHHNVGGLPEVMKLALIEPLRELFKDEVRKVAVELGMPDFIIWRHPFPGPGLAIRIIGEVTEERLEILRRTDKIVQSELVASGWYRKVWQGFAVLLPLKTVGVMGDGRTYENVAAIRVVDSLDAMTADWSRLPSEILAVMSNRIINEVKGVNRVVFDVSSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: DNLJ_BORRA
Sequence: MGKDIKDEILSLRDAIKKWDREYYVDSSPTVGDVTYDKALLRLQYLENRYPEYKTLDSPTLKFGSDLLNDFKEIEHSYPILSLDKAYDVKELLLWVEKMSLEGSNLGFDMGISAEPKIDGCSIVLYYKDGILEKALTRGDGRFGNNVIENVRTIKNVPLCIGERVELVLRGEIYITKKDFLKINHTLDDSYINARNLTSGILRRINSREVVNFPLDIFVYDILYSSLKLNTNHDAFDKLKHFGFKLNPFCKFFCGKNLGENIINYVKEIEEQRERFEYEIDGVVLKVNDFRLRDVLGYTSHHPKWSIAYKFESLRAVSKVIDIVVQVGRSGKITPVANIEKVLIAGAFITSASLHNQDYIDSIGLNVKDVVAISRRGDVIPAVELVVEKLSVGNFKIPNYCPSCKKSLIKEGAHLFCVNIHCPLKIMGHIKYFCSKKCMNIVGLSEKTIEFLFNMNFISSEIDLYTFDFDRLIGLKGFNFKRVNKLKRSIEESKNRPFKKLLLAMGIKDLGINTILLLINNNLNSFDAISLLCQDNKNALVKLLDIKGIGERIAFNIIRAFNDKIILDKFNFFKKLGFKMQEDSMNCVIDSSFLFGKKFCITGSFDEYSRHVLIDKITKKGAIFHSAVSRYLDFLLVGKSPGLKLKKANNLGIKILSLFDIKNLVNLDD
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: SYC_HALHL
Sequence: MLKIHNSLTGAKEPFQPIEPGQVRIYVCGMTVYDFCHLGHARALVVFDAVVRYLRWLGYEVTYVRNITDIDDKIIRRAAENGEPMTALTDRFIRAMHEDCSALGVEPPDHEPRATERLESMIALIEELIAGGHAYVGDNGDVYFSVASFPEYGKLSGRRVEELRSGSRIEPDEAKHDPVDFVLWKAAKSGEPAWPSPWGDGRPGWHIECSAMSRDLLGSHFDIHGGGVDLQFPHHENEIAQSECASGHRFVNYWMHNGHVRIDDEKMAKSLGNFFTVRDVLAEHPAEVVRLFLLSSHYRSPLNYTGDALDEARGGLERLYNALRGLPAAAPARSQARERFREAMDDDFNTREALAVLFDGAREINRLREAGDASGAASAAAELRELGAVLGLLQQDPEAYLRGDVADAEAEEIESLVAQRTAARKAKDFAEADRIRDELQARGIELEDTPEGTKWRRTR
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_GEOMG
Sequence: MKIYYDKDCNMGVLKGKKVAIIGYGSQGHAHANNLKDSGIDVVVGLRADSASVKKATEAGLTVLPTSEAVKIADVVMILLPDETQGDIYREEIGPFLKQGAYLAFSHGFNIHFGQIVPRPDVNVIMIAPKGPGHLVRHEYTKGGGVPSLIAIHHDPAGNSRDVALAYASANGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYEGGIANMRYSISNTAEYGDLTRGPRVVTDETKKEMKRILDEIQTGQFAKEWMLENKANKPVFTALRRKGAEHQIEEVGARLRSMMSWIGASKIVDKAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: TILS_TROWT
Sequence: MLHRPRITPAVANARRAMLNTLPADLHNQLVLIALSGGRDSLAAMVIASWVIPRLNGRVGAVVVDHGLQENSARIADEVRIRAEQFALNPILIKRVSPSRVSAGPEASARIARYAAFYDALEETKAYAIILAHTLDDQAETVLLGLMRGSGPSSLRGMKAVSYTPEDCRYMNNKACNSVTAVYAHNTQRCSCDSTQRCSCDSRPYPPPPEPRNENRSYFPHPSCKCVEGSATRFTNADIDSRFGVFIRPFLDITRHETGKICEFYGLDYWNDPHNEDVRFSRVRIRHNVMPVLENEIGPGVKYALSRTAKLAQLDTEYLDHLSNELLDEIASKESDWSIRLPINTLQKTPVPIRLRVIRLAALQYFTVSLSFKHTRQIERLLCSSCDIKHVNLPRLITAQRVGNYIYMHTLRGKL
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_PARPJ
Sequence: MAIERTLSIIKPDAVAKNVIGQIYSRFENAGLKIVASRMVHLSRADAEKFYAVHAARPFFKDLVDFMISGPVVVQALEGENAILKHRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAAETAAVEIAFFFPQVNVYSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_ECOLC
Sequence: MSTDNKQSLPAITLAAIGVVYGDIGTSPLYTLRECLSGQFGFGVERDAVFGFLSLIFWLLIFVVSIKYLTFVMRADNAGEGGILTLMSLAGRNTSARTTSMLVIMGLIGGSFFYGEVVITPAISVMSAIEGLEIVAPQLDTWIVPLSIIVLTLLFMIQKHGTAMVGKLFAPIMLTWFLILAGLGLRSIIANPEVLHALNPMWAVHFFLEYKTVSFIALGAVVLSITGVEALYADMGHFGKFPIRLAWFTVVLPSLTLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLIIAALATVIASQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPFVNWMLYVAVVIVIVSFEHSSNLAAAYGIAVTGTMVLTSILSTTVARQNWHWNKYFVALILIAFLCVDIPLFTANLDKLLSGGWLPLSLGTVMFIVMTTWKSERFRLLRRMHEHGNSLEAMIASLEKSPPVRVPGTAVYMSRAINVIPFALMHNLKHNKVLHERVILLTLRTEDAPYVHNVRRVQIEQLSPTFWRVVASYGWRETPNVEEVFHRCGLEGLSCRMMETSFFMSHESLILGKRPWYLRLRGKLYLLLQRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENGB_RUEPO
Sequence: MTALPFPVAEEPDAFTAETGRKLFAGPSEFVKGVVAMSGLPPADRVEVCFAGRSNVGKSSLINALTGTKGLARASNTPGRTQEINFFTQGPELYLVDLPGYGYANAPLKVVEKWQKLLKQYLSGRQTLRRAFVLIDARHGVKAVDDEIMKLLDTSAVTFQCVLTKADKVKAAERDKVLAQVRAALAKHPAAYPEIVLTSSEKGDGIATLRSIIAHLE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: CYB_HARDI
Sequence: MAPNIRKHHPLLKMINNSLIDLPTPSNISAWWNFGSLLGICLMTQILTGLLLAAHYTPDTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLYKETWNTGVVLLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFTLHFLLPFMISGLTIIHLTFLHESGSNNPLGITSNSDKIPFHPYFSLKDILGFTIMLLLLTSIALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLAPFLHKSKQRTMTFRPLSQLLFWLLVANLMILTWIGSQPVEHPFIIIGQLASITYFTIILILFPITSALENKMLKY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CH60_ERWT9
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIVNEGLKAVAAGMNPMDLKRGIDKAVIAAVEELKKLSVPCSDSKAIAQVGTISANSDETVGELIALAMEKVGKEGVITVEEGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIRELLPVLEAVAKAGKPLLIVAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAVLTGGTVISEEIGMELEKAGLEDMGQAKRVVISKDTTTIIDGTGEEVAISGRVTQIRQQIEDATSDYDREKLQERVAKLAGGVAVLKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALVRVAAMLTELRGQNEDQNVGIKVALRAMESPLRQIVSNAGEEPSVVTNAVKAGEGNYGYNAQTEEYGNMIDFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKGDAPDLGAGGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSLA1_ARATH
Sequence: MSLFLKPFLFLYDTTLSLLLLLFNGWSLEDTAAAQKRREADKNAAETEWIQLQYLWTKTRSVVLLPVFKGLVVMCLVLSIIVFFESFYMNFVILFVKLFKRKPHKVYKWEAMQEDVEVGPDNYPMVLIQIPMYNEKEVFQLSIAAICSLVWPSSRLVVQVVDDSTDPAVREGVDVEIAKWQSQGINIRCERRDNRNGYKAGAMKEALTQSYVKQCDFVAVFDADFQPEPDYLIRAVPFLVHNPDVALVQARWIFVNANKCLMTRMQEMSLNYHFKVEQESGSTRHAFFGFNGTAGVWRISAMEAAGGWKSRTTVEDMDLAVRVGLHGWKFVYLNDLTVRNELPSKFKAYRFQQHRWSCGPANLFRKMTMEIIFNKRVSIWKKFYVIYSFFFVRKVAVHFLTFFFYCIIVPTSVFFPEIHIPSWSTIYVPSLISIFHTLATPRSFYLVIFWVLFENVMAMHRTKGTCIGLLEGGRVNEWVVTEKLGDALKSKLLSRVVQRKSCYQRVNSKEVMVGVYILGCALYGLIYGHTWLHFYLFLQATAFFVSGFGFVGT
What is the function of this protein?
Probable mannan synthase which consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose.  The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase.  Galactomannan is a noncellulosic polysaccharides of plant cell wall.
What are the official names of this protein?
Probable glucomannan 4-beta-mannosyltransferase 1, Cellulose synthase-like protein A1, AtCslA1, Glucomannan synthase, Mannan synthase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: ECHD1_XENLA
Sequence: MGIFVWRSSLSMTNIRWLHHRCLSLYNSSHGFNEAKIKKKLAQFTGGSVDLSKSDDGIAEICINNPTRMNAFTGTMMIELEERISDLENWQDGKGLIVYGAENTFCSGSDLNAVKAISNPQEGMMMCMLMQNTLTRLQRLPLVSVALIQGKALGGGAELCTACDFRLMTEGSEIRFVHKQMGLVPGWGGAARLIHIVGSRHALKLLSGAPRVQPENALELGLADNILTGTEAGVLSEAKNWIMPYIKGPSDVTRAVKKVIISGREQNLEDALRTEKEIFGTVWGGLANLQALAKGTKHK
What is the function of this protein?
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading.  Also has methylmalonyl-CoA decarboxylase activity at lower level.
What are the official names of this protein?
Ethylmalonyl-CoA decarboxylase, Enoyl-CoA hydratase domain-containing protein 1, Methylmalonyl-CoA decarboxylase, MMCD.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RSME_BUCAI
Sequence: MFTSTAIKNKKIPRIYIEDDLDLNQFYFLSDENRHYVTKVLRMKIEDILEIFNNTHYIFFAKIIDISKKIIKIQTFKKILKNLESPLHIHLGQVISKNEKMDFTIQKSIEIGVKTITPLFFENDHFQKKRINFSNKIKRWEKIAISACRQCNRNIIPKIKIPMNVFHWCENNQNNDKKIIFHPKSTLTMKCLTEPIKYIQIIIGSERGFFNDEFQKIIKYGFIPIRLGPRILRTETASVVAITALQTMFGDFK
What is the function of this protein?
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA.  Acts on the fully assembled 30S ribosomal subunit (By similarity).
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase E, 16S rRNA m3U1498 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RsmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_RICAH
Sequence: MRQSGRKSNQLRPISLELSPLINTEGSCIIKIGNTHVMCSATCETTVPPFLRGQNQGWVTAEYGMLPGSTSQRIKREAAQGKQGGRTQEIQRLIGRSMRCVMDLKKLGERQIIIDCDVINADGGTRTASITGSYVALHLAIRSLMKKRILKVNPLISQIAAVSCGIYKGEAILDLDYLEDSDAEVDSNFVFAGNGNLIEVQGTAEQEPFSEEQFIEMLKLAKCGAAELFKLQNQVLLGT
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: ISPH_XANOR
Sequence: MYVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEELDEVPDDATVIFSAHGVPQAVRQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIGHAGHPEVEGTMGQWSRERGPGTIYLVEDIEQVATLDVRQPENLAYTTQTTLSVDDTMGIIEALRARYPAMQGPRHDDICYATQNRQDAVRDLARQCDLVLVVGSPNSSNSNRLSELARRDGVESYLIDNASEIDPAWIVGKQHIGLTAGASAPQVLVDGVLARLRELGASGVSELEGEPESMVFALPKELRLRLVG
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PYRF_RHOBA
Sequence: MMTFATQLNAAILRTGSVTCVGLDPRLEQLPKPLRDSVSEKRKDSVAAAYTQFCCEIIDAVAGLVPCVKPQAAFFEQLGPAGMVSLGEVISHANQAGLIVITDGKRNDIGSTATAYADAYLGSAEPDRSPWGSDALTVSPYLGRDSLEPFVEVCDRRAAGIFVLVKTSNPGGGYLQDLSVDGKTIYQSVAELVTELNKSRLDADGYGPVGAVVGATYPEQLVELRKAMPHSILLVPGFGAQGGSADDVRAAMDANGAGAVVNSSRHIVFAHKREEFSVAADESNWQDAVRAATIQMNEQLKG
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: CRCB_ERWT9
Sequence: MIKPLLAVMIGGCAGCVIRWLLAVRLNAWFPNLPPGTLLVNLVGGLIIGATVAWFARYPGIDPNWKLLITTGLCGGMTTFSTFSLEVVTLLQAGNYLWAVISVLTHVTGSLLMTIAGFWLVSLLF
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCRA_SCHPO
Sequence: MHPDQIRQLRLQESSNTHPNLAILFIFIALAAVIVLLICLLSVILLLRYTRHGRILLKNTNPGELDDEALENEHIDEEGFSLLDDMGKERYLQAREFELNSMKSNVNTDAKLLDFLQVQEKGVLAWHFIPNQEYNCYVKNKTELSFLGNEECCMQTNLPLQRINEVYYFEVKLLDVPIDTLVSIGLATKPYPPFRLPGWNFWSTAYVSDGTRRSNSPFTGKPYSSFYQQGDVIGVGYKPKCNRIFFTRNGRRCAELPCTYRNLYPTVGAIGPCTLHVNLGQAGYVFIEANIKKWRLAPAVGSLAPPPSYSTSQPTISWDAASESSAGTTTQGDTNRPDKSKNRSPPINFDGTSYDAAGNVFSPSSSNNQAYQMHSMPATDEV
What are the official names of this protein?
SPRY domain-containing protein C285.10c.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass membrane protein.
Protein: ISPD_CHLAB
Sequence: MYGVSMDPKCSLILLSGGKGERFGANQPKQYLPFRGEPLILHALNMALRIPEISEIIVVCDVNYESIFEGYPVKFARPGTRRQDSVFSGLQQVANPWVLVHDGVRPFIYPDEVTELVTAAYQTGAATLVSNVPYTIKQRDPVKTLDRDALSIVHTPQCIKTQILLEGLERANQERITLVDDTQAAELLNLPVALVFNKHPQIKVTYPEDLTLAHALL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.