PharMolix/UniProtQA huggingface dataset:
Protein: ECCA5_MYCTU
Sequence: MTRPQAAAEDARNAMVAGLLASGISVNGLQPSHNPQVAAQMFTTATRLDPKMCDAWLARLLAGDQSIEVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSDGLFLRLAITSVDSLACAYAAVLAEAKRYQEAAELLDATDPRHPFDAELVSYVRGVLYFRTKRWPDVLAQFPEATQWRHPELKAAGAAMATTALASLGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAVELLRRVYSRDAKFTPAREALDNPNFRLILTDPETIEARTDPWDPDSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTKVNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPLVVETSRTKLLGRYMADAEKNTEEMLEGALGGAVFFDEMHTLHEKGYSQGDPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRFSTVIEFFSYTPQELIALTQLMGRENEDVITEEESQVLLPSYTKFYMEQSYSEDGDLIRGIDLLGNAGFVRNVVEKARDHRSFRLDDEDLDAVLASDLTEFSEDQLRRFKELTREDLAEGLRAAVAEKKTK
What is the function of this protein?
Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41 (PubMed:22340629, PubMed:22925462).  EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity).
What are the official names of this protein?
ESX-5 secretion system protein EccA5, ESX conserved component A5, Type VII secretion system protein EccA5, T7SS protein EccA5.
What is the protein family that this protein belongs to?
Belongs to the CbxX/CfxQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GDL71_ARATH
Sequence: MDSLIKLFFCLFIFLCTSLLFGEINGVEGSNQNHHLYPFRPTKLFVFGDSYADTGNIKKAFSSSWKFPYGITFPGKPAGRFSDGRVATDFLAKFVGIKSPIPYFWKDYAGKKRLQYGMNFAYGGTGVFNTQTPLPNMTTQIDIFQNILTTGDIYYPPELTSSVALVSVAGNDYSNFIALNRPASEFPAFIKQVVDQTEVNLRRIHALGVKKIAVPSLQPLGCLPPFTFVTSFQRCNETQNALVNLHNNLLQQVVAKLNNETKQSTFIILDLYNAFLTVFKNKGSNPGSTRFESPLKPCCVGVSREYNCGSVDEKGVKKYIVCDNPKTAFFWDGLHPTEEGWRSVYSVLRESLTASLIKA
What are the official names of this protein?
GDSL esterase/lipase At5g03610, Extracellular lipase At5g03610.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted.
Protein: PETN_MASLA
Sequence: MEIDVLGWVALLVVFTWSIAMVVWGRNGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: RS8_STRPM
Sequence: MVMTDPIADFLTRIRNANQVKHEVLEVPASNIKKGIAEILKREGFVKNVEVIEDDKQGIIRVFLKYGKNGERVITNLKRISKPGLRVYAKRDDMPKVLNGLGIAIISTSEGLLTDKEARQKNVGGEVIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: GLPB_ALIFM
Sequence: MNFDTIIIGGGMAGLSCALRCLEAGLKTAVIASGQSALHFSSGSIDVLAKTPSGEPVSNPMTCIDTFAKEYPNHPYATLGKETVERAIDWYRNTLSTIGVPLTSQNNGLNHYRLTPLGAMKSTWLSQPFVHQFPMDLEKNKTQKMVLITIDGFRDFQPKLAQDNLKQITQLSDLEITTANISLSAFNDIQRNHCELRSIDLSRLLSKRANRQELAYALQQHAQPGDLVVIPSIFGNGTGLTYLKEIEQLTKLTLCEVPTMPPSLLGIRLEESMKHAFIELGGTMLNGDHVVQGEFSYVDKSDPEHSHYRLNRIFTKNHGDFPLQAKQFVLATGSFFSQGLKANVDSMIEPIFGLDIAQSDKRTDWYSHDFFSTQSHPFLSMGIKTTANFQAIKSGHVIDNLYCAGAILSGYNPILEGSGSGVAISSGFHAAESIIEQLQPNDFFQNNNIKAEVAL
What is the function of this protein?
Conversion of glycerol 3-phosphate to dihydroxyacetone.  Uses fumarate or nitrate as electron acceptor.
What are the official names of this protein?
Anaerobic glycerol-3-phosphate dehydrogenase subunit B, Anaerobic G-3-P dehydrogenase subunit B, Anaerobic G3Pdhase B.
What is the protein family that this protein belongs to?
Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
Protein: SECB_STRMK
Sequence: MSEEITNGAAAPVDAATGPAFTVEKIYVKDVSFESPNAPTIFNDQVQPELQLNLNQQVQRLGENAFEVVLAVTLTCQAGERTAYVAEVKQAGVFGLVGLDPQSIDVLLGTQCPNILFPYVRQLISDLIQAGGFPPFFLQPINFEGLYAETLRQRQEQGDAPSLADSEPAGNA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FESII_AZOVI
Sequence: MATIYFSSPLMPHNKKVQAVAGKRSTLLGVAQENGVKIPFECQDGNCGSCLVKITHLDGERIKGMLLTDKERNVLKSVGKLPKSEEERAAVRDLPPTYRLACQTIVTDEDLLVEFTGEPGGA
What is the function of this protein?
Binds to and protects nitrogenase from irreversible exposure to O(2), in what is known as 'conformational protection' (PubMed:7830548, PubMed:7548055, PubMed:10220344, PubMed:26654855).  Shifts nitrogenase into an inactive, O(2)-tolerant state.  Exists in 2 states, an open oxidized state that binds and protects nitrogenase, and a closed reduced state that probably does not bind nitrogenase; cooperative oxidation of the 2Fe-2S clusters causes the conformation change (PubMed:26654855).  Does not protect nitrogenase with the vanadium-iron subunit, not clear if it protects the iron-only nitrogenase (PubMed:7830548).
What are the official names of this protein?
Protein FeSII, FeSII, Shethna protein FeSII.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEK2_HUMAN
Sequence: MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
What is the function of this protein?
Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells.
What are the official names of this protein?
Serine/threonine-protein kinase Nek2, HSPK 21, Never in mitosis A-related kinase 2, NimA-related protein kinase 2, NimA-like protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus. Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=STK3/MST2 and SAV1 are required for its targeting to the centrosome. Colocalizes with SGO1 and MAD1L1 at the kinetochore. Not associated with kinetochore in the interphase but becomes associated with it upon the breakdown of the nuclear envelope. Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. SUBCELLULAR LOCATION: [Isoform 4]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear.
Protein: MIAB_ACIBC
Sequence: MTVQTFIPNGAKAASENTVTQPTHTTDVSIKKLYIETQGCQMNEYDSHRMADLLGDSHGYVLTNNPNEADILLMNTCSIREKAQEKVFSELGRWRKLKEQNPDLVIGVGGCVASQEGDNIQKRAPYVDMIFGPQTLHRLPQMLDQHHAQVEKPKKEKIKLVDISFPDIEKFDFLPEPRVEGFKAFVSIMEGCSKYCSFCVVPYTRGEEVSRPLDDVLAEIAGLAEKGVREISLLGQNVNGYRGETFEGGICTFPELLRLVAEIPGIGRLRYTTSHPLEFSDELIQCYEDLPQMVSHLHLPVQSGSNDVLKAMKRNHTIDVYIDKIAKLRKIRPDMHLSSDFIIGFPGETDENFAETLQFIKDLDFDHSYSFVYSKRPGTPASDLPDTTPEHVKKERLAQVQQVIKQSSIEKTDAMLGKIERVLIEKVSDQDPNILVGTADNTRLVTFVGDASWIGRFAEIEITEIKTLNLVYGELLNLEPDVA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_LEPBL
Sequence: MARRCEVTGRGTVSGNNVSHSHIKTRRTWKVNLIKKRIFLEDENRWVTIRLSTRALRTLRKKGIKAAIKDNGGSLGVLAPKKYAGITKQALKKA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: DCLK_DROYA
Sequence: MELDKVKTHSLHCNAAVLSSLQAPTSATSPQSFTSKANAVAEAAFIENSNQQQNVQKDLNSHNRDCDSPVSSTSELEKEFDDLRKLHTSSLTNSVVVGKSTGSLNGDYSITSATSKTKTLESVVTINSATGSACLTIASTADHIKKRIPNSRTPTRKALRIKFYRNGDRFYPGVTIPVSNERYRSFERLFEDLTRLLEENVKIPGAVRTIYNMCGKKITSLDELEDGQSYVCSCNNENFKKVEYNPGSQPLSNLTLTNNSRPYNQRLAKHRPASPLKNGLLVGSSPLAVCGGGTGNGSPLIASKSSDRVTVVHPRIVTLIRSGTKPRRIMRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGISVVQLSDFFESDDVFFAYGTERINTAEDFKLEPEELKAINVIRKTMRTAGTTCKGPKPKMPIKSKKVYPPSVNSEAFKAATAPEDDRHATLLTSTGIEINELPSNIRSTYTLGKIIGDGNFAIVFKIKHRQTGDSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFAESQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQSDPDVRFTSEDILDHYWTIGNEGNECTTYKR
What are the official names of this protein?
Serine/threonine-protein kinase GE16371, Doublecortin-like and CAM kinase-like protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Protein: VF337_IIV3
Sequence: MSSIVNGFSIQKSTKTAYDTQQPCDCWDCSAFTAVVGCGQTDGMDDWEFGETACCFTCPNKKQCAKPDPAECNIGTDSHQRDPLTRVTWNGRGPNVQCVYDVNRINTLEQIDNFKQRFGVHGDYNAVVANYCQQSSDSCITDPETGTKMTKCSRFKSDQKDGELCRGWFNQQPKAVQDTVVQNYCAVNNTPDCKCVNRAQNEVYRELKIGKVINDGCWFTPCANPQSYLLTTEVENPTCPSNFCDIIYNIIKDRDVTIDDVKNDINCVFKPDPPPQPKPQPPPDPPKPPPDPPKPDPPPPPPPKPTPPPDPPKPKPDPVPPPKPTPPPPKPTPPPPIPPQPVPILPIPPVDLKKNWIMLTFVGLVLALVIYPKSRHAIGTHTWRNAAIAVLVGLNAFGLQSYVNNHV
What are the official names of this protein?
Putative membrane protein 047R.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 337L family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein.
Protein: SRP_CHLPN
Sequence: MSSNLHPVGGTGTGAAAPESVLNIVEEIAASGSVTAGLQAITSSPGMVNLLIGWAKTKFIQPIRESKLFQSRACQITLLVLGILLVVAGLACMFIFHSQLGANAFWLIIPAAIGLIKLLVTSLCFDEACTSEKLMVFQKWAGVLEDQLDDGILNNSNKIFGHVKTEGNTSRATTPVLNDGRGTPVLSPLVSKIARV
What are the official names of this protein?
Sulfur-rich protein, Cysteine-rich protein A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HTRA_BACSU
Sequence: MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRGFGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKKSSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSGSGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDDHVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSINVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELLSKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKAEDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS
What is the function of this protein?
Degrades abnormal exported proteins and responsible for the propeptide processing of a natural pro-protein and for the maturation of a native protein.  It also plays a prominent role in stress (heat shock, ethanol, puromycin and NaCl) resistance during active exponential growth (Probable).
What are the official names of this protein?
Serine protease Do-like HtrA, HtrA-like serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HSLO_STRP2
Sequence: MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGRTLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATGEVLVGPFVGNGQFLVITDYGTGNPYNSITPLISGEIGEDLAFYLTESQQTPSAVGLNVLLDEEDKVKVAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIYGDEAYKRLSEEEIRFQCDCSHERFMNALASLPSSDLQEMKEEDHGAEITCQFCQTTYNFDEKDLEELIRDKS
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCD2_HUMAN
Sequence: MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP
What is the function of this protein?
In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424).  Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705).  The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424).  The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705).  Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
What are the official names of this protein?
3-hydroxyacyl-CoA dehydrogenase type-2, 17-beta-estradiol 17-dehydrogenase, 2-methyl-3-hydroxybutyryl-CoA dehydrogenase, MHBD, 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)), 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase type II, 3alpha(or 20beta)-hydroxysteroid dehydrogenase, 7-alpha-hydroxysteroid dehydrogenase, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, Mitochondrial ribonuclease P protein 2, Mitochondrial RNase P protein 2, Short chain dehydrogenase/reductase family 5C member 1, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: FADI_SHEON
Sequence: MSDRQQVTNARGERIAIVAGLRTPFAKQATAFHGISALDMGKMVVNELLVRSELDPKLIEQLVYGQVVQMPAAPNIAREIVLGTGMDVSTDAYSVTRACATSFQSAVNVAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLNKARTFGQKLQIFRRLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLANETWASGHLRDEVMVAHVPPYKQFIERDNNIRENSDLASYAKLRPAFDKKHGSVTAANSTPLTDGASAIILMSEGRAKALGYQPIGYIKSYAFTAIDVWQDMLMGPSYATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGDIDMSKFNVLGGSLAYGHPFAATGTRLITQVCRELKRRGGGTGLATACAAGGLGAAMIVEVE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STS1_ARTGP
Sequence: MNSLVATPPVPPHFYETSCRSASYSMSSTNASVNRKRKAEDDCLPSDDTRMSASPSGSPALHPRPLAPRHLKRSRPNVSGRPLSLPRLMETLDTDALRSVLRSLCDRHPEIASEVMHTAPRPSVSAALEVLNNYQSTLQSSFPLGGNPSSDYAYNRVRQHLTNLLEALNDFTPHFLPPNESQPSTSLNYLDGATDIIHRLPRWTTPQHNLEKYAAYEEMSKAWCLVIREAAKRGGGIQLQYGGWDQKLAKHNETAGGKLQDAVNELNQSLGWIGGNVGNPSYPGGSNSQGDMSIRQQLMSGTYGAGLPLKVGPW
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HEM3_PROMI
Sequence: MPKSTIRIATRQSPLAMWQALYVKEQLQIAHPSLVVELVPMVTKGDIILDTPLAKVGGKGLFVKELELALLSSRADIAVHSMKDVPIDFPEGLGLVTICEREDPRDAFVSNHYDSLEQLPAGSVVGTSSLRRQCQLKALRPDLIIRDLRGNVGTRLSKLDNGDYDAIILAVAGLKRLKLTERIRSSLSAEQSLPAVGQGAVGIECRLDDHDTQALLAALNHADTATCVKAERAMNTRLEGGCQVPIGSYAIWQNDKIWLRALVGAPDGKTILRGERLVSPEDAEQAGISLAEELLDKGAREILTAVYQGNTAI
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RL10_SHEDO
Sequence: MALRLEDKKAIVAEVNEAAKGALSAVVADSRGVTVGAMTVLRKAARANGVYVRVVRNTLAKRAVEGTAFECLAETFTGPTLIAFSNEHPGAAARLLKDFAKGNAKFEVKGAAFEGMFIPAVDIDRLAKLPTYDEALAQLMMTMKEASAGKFVRTLAALRDQKQEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: THII_MACCJ
Sequence: MQYDHILVRYGELTLKSGNRNTFINQLKSNIKYALIPLTGYKVNANRDRMYVEITEDADAEEIMKRISKVFGVHSVSPVVKVEKNIDQIKSSAVKLARDIDAPGVTFKVDAKRSDKGFPYDTFALQQELGGEILSNIEHLTVDVKNPDYKLLVEIRSDAAYLYSRVIKGAGGLPVGTGGKTLLMLSGGIDSPVAGIEVMKRGVTIEAIHFHSPPFTSEEAKQKVIDLTRIMAETTGEIKLHLVPFTDIQKMIHKKVPENLTMTSTRRMMLKIADRFARQIDAKALVNGENLGQVASQTLGSMYAINAVTNLPILRPLLTLDKDEIIIKAKEIGTFDTSIQPFEDCCTIFTPKNPKTNPRLDKVESFEAGTDFDAMIEEAVANIETLTISKHTNTKKEFEDLL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RH47A_ORYSJ
Sequence: MRLTVGQVHRHVLALASSRSCFVLGDHLPFRMLSLPRVVRFHQTAWHDIQTVEDKSGPLTLASLEVQNKVEYVKKERATRTGGIKPSSRASALNMKPKVSSFNAKPVKSALPKSAVLKKTLKIDESLFSAKSFEELGLPPLLIDRLNKEGLTAPTEVQSAAIPIISQKHDAVIQSYTGSGKTLAYLLPILSEIGPLKRPTEQDSSDKRSGVEAVIVAPSRELGMQIVREVEKILGPNDKRLVQQLVGGANRSRQEEALKKNKPIIVVGTPGRISEISAAGKLHTHSCRFLVLDEVDQLLSFNYREDMHRILEHVGRKSGTSSRDILGPLARRSERQTILVSATIPFSVIRAARSWGHDPVLVRAMSVVPLESITVPRPVLSQPDANSNSPSNSVNQAAVDSLPPSLEHYYCTSKAQHKVDTLRRCIHALEAQTVIAFMNNTKPLKDVVFKLEARGMKATELHGDLGKLARSTVLKKFKDGEFRVLVTNELSARGLDVPECDLVINLDLPTDSTHYAHRAGRTGRLGRKGTVVTICEETETFVVRKMRKQLAVPIKPCEFTEGKLLVHKEEDVE
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 47A.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family.
Protein: PEX12_YEAST
Sequence: MSFYSNLPSAGQSSRGSSTSGRNGVGLEPLYPTIFEIMSSQEIDSLLPASIRYLLANHLVANFPNRYTLRLNKYFFEWFQAIKGFVEWYHLKTYNSTFIDRFYGLQLFSSRDRNLALTQCLNPKGQSEWPQGLQLNQQQKSVIFLEKIILPYITAKLDEILEKISMNNIFSSDETENKWPKRAFLRIYPFIKKLLALSNLLVKLLFLTKRTGSVSLLQYLFKIEYTTVRPLSSELSGLKETKGMDNRLRKTNISSIFALMQGQLSIIPRFLTFMGSQFFPTFIFVLRVYQWWTTQDMTTKLQKRVNDLDEDIPRPPFSSHSDKTEDKEGVSEACPVCEKTVQNPCVLETGYVACYPCAISYLVNNEGHCPVTNKKLLGCTYNKHTNKWEVVTGIRKLLI
What is the function of this protein?
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:9090384, PubMed:19687296, PubMed:22471590, PubMed:11370741, PubMed:35768507).  The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507).  PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:35768507).  When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (PubMed:35768507).
What are the official names of this protein?
Peroxisome assembly protein 12, Peroxin-12.
What is the protein family that this protein belongs to?
Belongs to the pex2/pex10/pex12 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: HEM1_KLEP3
Sequence: MTLLALGINHKTAPVDLRERVTFSPETLDQALESLLAQPMVQGGVVLSTCNRTELYLSVEEQDNLQEALIRWLCNYHGLNEEDLRKSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSSRGHLNVSELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLARQIFESLSSVTVLLVGAGETIELVARHLREHHVRKMVIANRTRERAQALADEVGAEVIALSDIDERLKEADIIISSTASPLPIIGKGMVERALKARRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQNIIQHNLAQRKAAAVQAESIVEQETSEFMAWLRAQSASETIREYRSQSEQVREELTAKALAALEQGGDAQEIMQDLARKLTNRLIHAPTKSLQQAARDGDDERLHILRNSLGLE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: HISZ_STAAB
Sequence: MNNSEQLIALKESETAFLKYFNKADYELVDFSVVEKLDWKQLNHEDLQQMGERNFWQHEHQIYAIRNDFTDQLLRYYSMYPTAATKVAYTGLIIRNNEAAVQVGLENYAPSLANVQQSLKLFIQFIQQQLRDNVYFVVLGHYQLLDALLDKSLQTPDILSMIEERNLSGLVTYLSTEHPIVQILKENTQQQLNVLEHYIPNDHPALVELKIWERWLHTQGYKDIHLDITAQPPRSYYTGLFIQCHFAENESRVLTGGYYKGSIEGFGLGLTL
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O164_CONVR
Sequence: MKLTCVLIITVLFLTASQLITADYSGDKRQYRAVRLRDEMRNFKGARDCGEQGQGCYTRPCCPGLHCAAGATGGGSCQP
What is the function of this protein?
Ion channel inhibitor that inhibits the increase in intracellular calcium upon depolarization in DRG neurons.  In vivo, both intraperitoneal and intracranial injections into mice induce hyperactivity.
What are the official names of this protein?
Conotoxin Vi6.4.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.