PharMolix/UniProtQA huggingface dataset:
Protein: MNHE2_STAAW
Sequence: MNQIVLNIIIAFLWVLFQDEDHFKFSTFFSGYLIGLIVIYILHRFFSDDFYVRKIWVAIKFLGVYLYQLITSSISTINYILFKTKDMNPGLLSYETRLTSDWSITFLTILIIITPGSTVIRISQDSKKFFIHSIDVSEKEKDSLLRSIKHYEDLILEVSR
What are the official names of this protein?
Putative antiporter subunit mnhE2, Mrp complex subunit E2, Putative NADH-ubiquinone oxidoreductase subunit mnhE2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSCA_BURO1
Sequence: MALLQISEPGMAPAPHQRRLAVGIDLGTTNSLVAAVRNSVPEVLPDEAGRVLLPSVVRYLEKGGRRIGHEAKEQAATDPRNTIVSVKRFMGRGKAEVEGAANAPYEFVDAPGMVQIRTIDGVKSPVEVSAEILATLRYRAEDSLGDDLVGAVITVPAYFDDAQRQATKDAARLAGLNVLRLLNEPTAAAIAYGLDNAAEGLYAVYDLGGGTFDLSILKLTKGVFEVLAAGGDSALGGDDFDHALFGHVLAQAGIDAKTLAPEDVRLLLDRVRVLKEALSSAPEAALDVTLSSGAHLVQTISHDTFASLVEPLVQRTLTPTRKALRDAQVTPADIKGVVLVGGATRMPVIRDAVAKYFGQPPLVNLDPDQVVALGAAIQADLLAGNRGTGDDWLLLDVIPLSLGVETMGGLVEKIIPRNSTIPIARAQEFTTFKDGQTAMAIHVVQGERELVADCRSLARFELRGIPPMTAGAARIRVTYQVDADGLLSVFAREQLSGVEASVVVKPSYGLADDDIAKMLEDSFKTAEIDMRARALREAQVEAERMLEATQAALAADGELLETDERAQVDALAAALRAVAQGDDTNAIEAATKALADGTDEFAARRMDKSIKRALSGRRLDEI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MNME_LYSSC
Sequence: MEFDTIAAISTPMGEGAIAIVRLSGDEAVAIADKIFKSPGGKSLTTKDSHTIHYGHLVDPKTNEVVEEVMLSLMRGPKTFTREDVVEINCHGGLVSVNRVLQLALTNGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVALGQMDGKLSRLIGDLRQALLETLAQVEVNIDYPEYDDVEEMTVPVLVEKCTWVRDEIIKLLQTSSQGKILREGLSTVILGRPNVGKSSLLNSLVQENKAIVTDIAGTTRDIIEEYVNVRGVPLRLVDTAGIRETEDIVERIGVERSREALRGADLILFVLNYADELTAEDERLFETIEAMDYIVIINKTDLPQKINLARVKELAGKHRIVTTSLLQEEGVTELEEAIAALFFEGQIEAGDLTYVSNARHIALLHQAQATVEDAIAAAQAGVPVDMVQIDVTRTWELLGEIIGDTVQESLINQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_CHESB
Sequence: MNDMGLVIVGAGGRMGQTLIRTVHAMEGVRVVGAIERSGSPHLGRDAGELAGIGIINVEICDEPLSVFAKADGVLDFTTPKATVEFAGYAAQARIVHVIGTTGLSGEDEAAIAAAARHATIVKSGNMSLGVNLLSVLVKQAARALDAADFDIEILEMHHRHKVDAPSGTALLLGEAAAEGRAIELADKSVRVRDGHTGPREAGTIGFATLRGGSVVGEHSVILAGIGERIVLSHLAEDRTIFARGAVKAALWARGRKPGLHSMLDVLGFTENSDQAR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_THEP3
Sequence: MKISVLGAGSWGTAIAIHLNRLGHQITLWLRDKNQFEEIVSTRHNKKYLDVDIPQEISITTDLKEAVTNSEIVVIAVPSHAVREISEKLKEVVDKNFIVVNLAKGIETSTLKRMSEVIKEYLSNDVVVLSGPSHAEEVVRQIPTACVLASLNVKACEIVQDAFMDENFRLYINKDVVGVELGGSLKNIIALGAGISDGLGFGDNTKAALMTRGLAEITRLGVALGSDPLTFLGLAGVGDLIVTCTSMLSRNRRAGILIGKGKSLEEALKEIGMVVEGVNTTKSAYRLSQINKIEMPITKEIYSILFEGKNPYEAVYSLMTRDKKHELHGI
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INT13_DROSI
Sequence: MFERNQKTIFVLDHTRYFSIASEEYISMDFLKGKPSGDGGATGAAGNATGSGGSQFSKSLWTCACESSIEYCRVVWDLFPGKKHVRFIVSDTAAHIVNTWSPSTQNMSHVMNAMVMVGVPSRNVPTSSDYSVIHGLRAAIEALAEPTDEQLAAMADLGTDELPRIPNKGRVICITSARDNTSMKSLEDIFNTVLVQQNTLAAPPAKKGLVIDHCHLVILNIVPLGVESLVTNRSLLKISPLLDVEIHTVSAPDISYKLTHLILNHYDLASTTVTNIPMKEEQNANSSANYDVEILHSRRAHSITCGPDFSLPTSIKQGATYETVTLKWCTPRGCGSAHLQPCLGQFLVTPVDVTSRPSSCLINFLLNGRSVLLEMPRKTGSKATSHMLSARGGEIFVHSLCITRSCMDEAPSITDGPGGRVSDYRTAELGQLIKMSRMVPLKVKDPSAPPLTRRLPRYFPLTTSSSILFHLQRHISWLPHFLHLLVKEDMDKQDEVRCQQHIHELYKSASRGDVLPFTHTNGARLKLSKAKDQYRLLYRELEQLIQLNATTMHHKNLLESLQSLRAAYGDAPLKSEPGASLLRSFTESPLSPERLEPISSVGASGSSNSNSLLKASKRRMSSCGQRSLLDIISSAERSQSNKRLDFSGRLCTPLGQVAKLYPEFGTKDKDAVTTGASITPNVKEESVRS
What is the function of this protein?
Plays a role as a regulator of spermatogenesis.  Crucial regulator of the mitotic cell cycle and development.  Required for the correct dynein-dynactin perinuclear localization important for nucleus-centrosome coupling that occur upon meiotic progression of primary spermatocytes.  Crucial regulator of the mitotic cell cycle and development.  Plays a role in sperm motility and fertility.  May have a role in the PNG/PLU/GNU pathway (By similarity).
What are the official names of this protein?
Protein asunder, Cell cycle regulator Mat89Bb, Maternal transcript 89Bb, Set apart in position or space protein.
What is the protein family that this protein belongs to?
Belongs to the asunder family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with dynein-dynactin on the nuclear surface at the meiotic G2/prophase transition in primary spermatocytes. Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M.
Protein: NXF1_MOUSE
Sequence: MADEGKSYNEHDDRVSFPQRRKKGRGPFRWKCGEGNRRSGRGGSGVQSSRFEEDDGDVAMNDPQDGPRVRYNPYTNRPNRRGDGWHDRDRIHITVRRDRAPAERGGAGTSQDGTTKNWFKITIPYGRKYDKTWLLSMIQSKCSVPFNPIEFHYENTRAHFFVEDATTASALKGVNHKIQDRENRRISIIINASAPPYTVQNELKPEQIEQLKLIMSKRYDGNQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSSNRLYKLDDMSSIVQKAPNLKTLNLSGNELKTERELDKIKGLKLEELWLDRNPMCDNFGDQSSYISAIRERFPKLLRLDGHELPPPISFDVEAPTMLPPCKGSYFGTENLKSLVLRFLQQYYVIYDSGDRQGLLYAYHDGACCSLSIPYNPQNPVRKNLAEYVKDSRNVKKLKEPTQRFRLLKHTRLNVVAFLNELPKTQHDVNAFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNASPEEIQRAFAMSAPTPSSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTLLKAKGEIPEVAFMK
What is the function of this protein?
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway).  The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex.  ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.  Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.
What are the official names of this protein?
Nuclear RNA export factor 1, Tip-associated protein, Tip-associating protein, mRNA export factor TAP.
What is the protein family that this protein belongs to?
Belongs to the NXF family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Nucleus, nuclear pore complex. Nucleus envelope. Cytoplasm, Stress granule. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles. Nucleus; nuclear rim.
Protein: MALX3_YEAST
Sequence: MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
What is the function of this protein?
Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization.  Preferentially hydrolyzes isomaltose, palatinose, and methyl-alpha-glucoside, with little activity towards isomaltotriose or longer oligosaccharides.  Does not hydrolyze maltose.
What are the official names of this protein?
Oligo-1,6-glucosidase IMA1, Alpha-glucosidase, Isomaltase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CSN6_BOVIN
Sequence: MAATAAAANGTGGSSGMEVDAAVVPSVMASGVTGSVSVALHPLVILNISDHWIRMRSQEGRPMQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELDFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity).  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity).  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).  Has some glucocorticoid receptor-responsive activity (By similarity).  Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 6, SGN6, Signalosome subunit 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LFTR_TRIV2
Sequence: MQYDIASIIQGYAQGYFLMADDNDCLGWYGSRDRTLIPLDERFRYPKSLQRVLNQERFTVAINRDFAAVVAGCANRESTWISQELQEIYWLLHQTGYAYSFETWQGEELAGGILGIVIGGAFIGESMFYRIPEGSKVAMVKLVERLRQREFVMFDAQMMNPHLERFGAYRIKDKEYKTLLEKALLSSSTLI
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_SALSV
Sequence: MSDNDQLQQIAHLRREYTKGGLRRRDLPAEPLTLFERWLGQACDARLADPTAMVVATVDDKGQPYQRIVLLKHYDEKGLVFYTNLGSRKAHQIEHNPRISLLFPWHMLERQVMVTGKAERLSTLEVVRYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVSIEQMEFWQGGEHRLHDRFLYQRDDGAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: AFTC_MYCS2
Sequence: MYCALVTATDSITTKLLNAFRPRTSAPSTATVLRSVLWPIAILSVIHRSYVLGTNGYITDDFGPVYRAVINFKLGLDIYNEQFDHVDPHYLYPPGGTLLLAPFGYLPVDASRYWYISFNVLAFLIAAYLMLRIFDYTLSSVAAPALVLAMFCTESVTNTLVFTNINGCMLLGAVLFFRWLLKGGRNAELLAGAAIGLTLVVKPSLAPLLLLPVLNRQFYTLITAFGVPLVFNIAAWPLVPDPMNFVRHTVPYIMSTRDYFNSSIVGNGIYYGLPMWLILLLRVVFLLLAVGSLWLLYRYYRERDPRFWLLTSSGVLLTASFLLLSLGQGYYSTMLFPFLMTVVLPNSVLRNWPAWLAIYGFMTMDRWLLGHWPTTGRFLEYMKITYGWSLMLVVVFCVLYFRYLDAKQDGRLDQGIDPPWMARERTPAPV
What is the function of this protein?
Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall.  Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.
What are the official names of this protein?
Alpha-(1->3)-arabinofuranosyltransferase, Arabinofuranan 3-O-arabinosyltransferase, Arabinofuranosyltransferase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 87 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NIFU_AZOCH
Sequence: MWDYSEKVKEHFYNPKNAGAVEGANAIGDVGSLSCGDRLRLTLKVDPETDVILDAGFQTFGCGSAIASSSALTEMVKGADLDDALKISNRDIAHFLGRLPREKMHCSVMGRERLQAAVANYRGEELRTDHEKPQLICKSFAIDEVMVRDTIRANKLSTVEDVTKHTKRGGGCSACHEGIERVLSEELAPVARSSSCADQGQEEVKVLAPSRLRSWPRRLRATPKLSNLQRIRRIETVLAAIRPTLQRDKGDVELIDVDGKNIYVKLTGACTGCQMASMTLGGIQQRLIEELGEFVKVIPVSAGPRQMEV
What is the function of this protein?
May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
What are the official names of this protein?
Nitrogen fixation protein NifU.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
Protein: NU5M_LEITA
Sequence: SFYLYYASFFDIALFTVFIIDIIKFYILSGVIFYFFNIDCIMFFWRVFLFITMGFLFFIFTTWYFICFYMYICMFIWNLVIYFRYNLKYCLFFCMLFIIYI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AMPA_ACIF2
Sequence: MEIAVQCQNPTTDNSDCVVVGIYEGGILSPAATLVDLASGGALRALLDTGDFTGDCGDTQLLYQVPGMAAARVLVLGLGSHGKVKDSQFRKAALAAARALQGARVGRASLHLLDTPVIRRSAPACAKILVQAVADAEYHFDRHKKPADAPQRPISELQLSISENDTAALAELQGAVAEAQATARAVAWTRDMANEPGNICTPTWLAEQAEAMAGRLGIKSTILGPDAMEALGMHLLLGVAHGSRQPPRLIILEYRGGAENQAPIVLVGKGITFDAGGISLKPADKMDEMKYDMCGGASALAAIQAAAELQLPLNIVTVVPASENLPDGQATKPGDIHRSMNGLSVEVVNTDAEGRLILADTLTYVERFEPDVVIDMATLTGACIIALGHQTAAVMGNHEGLVHDLIAAGKESMDRVWELPLFEEYQEQLKSPVADLSNVGGRPAGTITAACFLSRFTENYRWAHLDIAGVAWKSGEHKGATGRPVPLLVEYLLRRARQVA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_STAAR
Sequence: MENFDKVKDIIVDRLGVDADKVTEDASFKDDLGADSLDIAELVMELEDEFGTEIPDEEAEKINTVGDAVKFINSLEK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_COXB2
Sequence: MKKNLTNIYLIGLMGAGKTSVGSQLAKLTKRILYDSDKEIEKRTGADIAWIFEMEGEAGFRRREREMIEALCKLDNIILATGGGVVLDEKNRQQISETGVVIYLTASIDTQLKRIGQKGEMRRPLFIKNNSKEKLQQLNEIRKPLYQAMADLVYPTDDLNPRQLATQILVDIKQTYSDL
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOLIN_BPR1T
Sequence: MKTFFKDMAERAIKTFAQAMIGALGAGATGLIGVDWLQALSIAGFATVVSILTSLASGIPGDNTASLVNNKKEGE
What is the function of this protein?
Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space.  Determines the precise timing of host cell lysis.  Participates with the endolysin protein in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.
What are the official names of this protein?
Holin.
What are the subcellular locations of this protein?
Host cell inner membrane; Multi-pass membrane protein.
Protein: SYV_EHRCJ
Sequence: MQSIFNNKYQFKNIETKYNTLWDTTKLYKWKNSGTNQFVIDTPPPTISGQLHIGHVFSYCHTDFIARYQRMLGKDVFYPIGFDDNGLPTERLVEKTKKIRATDISRKEFKTICTQVSHEFRIQFKQLFQSIGISYDWDLEYHTISKDIQKISQTSFINLYNKGKLYRKLQPIFWDCIDKTAIARAEVEENELSSFMNTIAFSTEAGKAINIATTRPELMPACVAVFFNPSDIRYQDLLGQNAIVPIFGNKVKILSDDQVKIDKGTGLVMCCTFGDEMDVYWWNKHNLDTKIIISKSGTIDHLNTLQGQDVCKQLHGLSITEARALIIEILERNNLLIQKQEITHNVKCAERSGAPIEILLSHQWFIKVVDIKHELLKQVQKINWHPQSMRKQIEIWIEGLNWDWCISRQRYFGVPFPVWYSKDGKIILPDINKLPIDPTNDLPEGYQDTEIEVETDVMDTWATSSLSTQFHNISATPADLRAQSHEIIRSWAFYTILQAYYHNNDIPWKNIMISGWCLAEDKTKMSKSKGNVLTPNKLLDEYGADVVRYWTANSKLGADTTFSNEILKLGKRFTTKLWNASKFVSMFIDQYSEPDLQYITETMDKWILSKLYKVIVKATESFNSFEYCIALDCIESFFWKDFCDNYLELSKKRAYGELISKQEHLSAVNTLSFVLRELLKMLAPFMPYVTEEIYRTLYSSNNSIHSHNTWPAADVNLYNESDELLGETFIEILNQVRKVKASAQLSVKYKINKLIINKHFPVSLENDLKAVCNADCIVYDNRQNDNKEQLLVSVEFENVQIT
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHA2_PANTR
Sequence: MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPADFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSNCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGTLLGCVPRWLLMNRPPPPLELCHPLHLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: NTPPA_YEAST
Sequence: MSGNSQLPPDVIGFICSKYDIILASTSPRRYEILHDIMGITDLKTMVSTFEENLDKMNYSTDPIGYVCDTSWHKAQNIIEILTDYEDENPNEIDKPKLIICADTIIIDKSGRIYEKPKTKEVQKKFLMKFCYEDDEPVNVVTAVTLIKWYGRENFELVPFRDETKVYFDNKIPLRILEEYVESGDGLEVGGGFKIQGQGAILIEKIEGDYYNVVGLPLNKTFKGLYAEANSI
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  Can also hydrolyze the modified nucleotides 5-methyl-UTP (m(5)UTP) and pseudo-UTP.  Has weak activity with CTP (PubMed:24210219).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219).
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Maf-like protein YOR111W, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_SYNAS
Sequence: MEKIVCIIPSRYSSSRFQGKPLADLCGKPMIQHVYERVLKSELVSYAAVATDDSRIFEAVRKFGGKAIMTAARHRSGTDRIAEAVNSLDLKDDDIVVNVQGDQPIFEPEQIAEVTRPLREDPSLPMATLIYRIVREEEITHPNAVKVVFDRNFNALYFSRATIPYVRDDRHPIAYYKHHGIYAYRRAFLRTFTALEEGTMERLESLEQLRALEFGYRIRVVETLHDSVEVDTPEELARVRDILLGRAR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_BACC0
Sequence: MHYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLDMKEDDVLGFAKALVNAKRDLAYCSVCGHITDRDPCYICNDSHRDQSVVCVVQEPKDVIAMEKMKEYQGVYHVLRGAISPMEGIGPEDINIPQLLKRLHDETVQEVILATNPNIEGEATAMYISRLLKPTGIKVTRIAHGLPVGGDLEYADEVTLSKALEGRREV
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RS9_STRZT
Sequence: MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVINQPFAVTSTVGSYDVFVNVIGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAGLLTRDSRKVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: TAL_CHLP8
Sequence: MKFFIDTASLDEIKAANELGVLDGVTTNPSLIAKIVKDPANFTYADFKAHIKKICDIVDGPVSAEVTTLKAEEMIAQGEELAAIHENVVIKCPLTVEGLKAIKHFSSNGIKTNATLVFSPTQALLAAKAGADFVSPFVGRLDDISTNGMELVKQIVTIYDNYGYLTEVIVASVRNPLHVVESAMVGADIATIPYSVIKQLANHPLTDKGLEKFMEDAGVMKP
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.