Protein: FMAB_ASPFU
Sequence: MTLTYGHKRLQDAPEPIAIVSAACRLPGHVNGPHKLWELLQSGGTAVSNEVPQSRFSSEGHFDGSGRPGTMKALSGMFIEDIDPAAFDAAFFNLTRADAIAMDPQQRQLLEVVYECFENGGIPIEKVRGKQIGCYVGSLNGDYHDMQMRDPEQRVSGHAVGTGRAILSNRISHFFDLRGSSFTIDTACSSGLVGVDVACKNLRAGTLTGAVVAGVNLWLSPEHTEERGTMRAAYSASGKCHTFDAKADGYCRAEAVNAVYLKRLSDAVRDGDPIRAVIRGTASNSDGWTPGINSPSAQAQAAMIREAYANAGIDSSEYAETGYLECHGTGTPAGDPTEVKGAASVLAHMRPPASPLIIGSVKSNIGHSEPGAGLSGLIKAMLVVEEGEIPGNPTFLNPNPAIDFDNLRVYATRIRIPWPKESSHYRRASVNSFGFGGSNAHAVLDNAEHYLGKYWASLEIPRSHLSSYINLSDMLSLFDGRRSSKTVTRRPQVLVFSANDMDSLKRQISTLSAHLLNPRVKVKLSDLSYTLSERRSRHFCRAFLLSYPAKSGHASKIAVEEAQFSKISQEATRIGFVFTGQGAQWSQMGLELVRTFPGVVKPILEQLDNVLQELPADLKSEWSLLQELTEARSSEHLSRPEFSQPLVTALQLAQLAVLQSWGVRAEAVIGHSSGEIAAACSAGLLTPRQAILNAYFRGLAGKSALATSPKGMMAVGLGAQDVQPYLEGVSADVVIACHNSPASVTLSGSASTLAELEGTIKAAGHFARMLRVEVAYHSPHMAKIANRYEELLKEHGRLDDGSKTNKRSNRMISTVTEDEVTGAQVCDAAYWKANMLSPVRFDGACNKLLTNTQLAPNFLIELGPSNTLAGPVTQIARAAKVDNLTYAAANKRGPDESSRAIFDVAGHLFLQNADISLDKVNLGDNTPDKAKPAVIVDLPNYQWKHSTHYWHESLASKDWRFKKFPSHDLLGSKVIGTLWQSPSWHKMLRLSDVPWLRDHRIGSEILFPAAGYLAMAMEAVRQAALSTATAEARELLKTRHYRYCLRDVQFPRGLVLEDDAEVHIMLLLVPMAKLGQGWWEYKITSLAESDSVASSSSSTLSPEKWNINSTGLVRLETILEASSSRAPEHTCSLPLDNPTPGQMWYKSLRDAGYSYGPSFQRLVAVESTEGKSATRSLISLEPPRSKWEPQSEYPLHPAPLDSVLQSMFPSLHRGNRTKLDQLLVPRGIGELTVSGDIWKSGEAISVTTWNKVSGDASLYDPASRSLIMQLNSVSFSPMLDGRDSLYMSHVYTQLTWKPDFQLLDTDEKLQQALSGGDGAASSLVQDLLDLAAHKAPNLRVLEFNLVPGSSESLWLAGHPTPRAVRTALTEFHFAANSADTALAAQEEYAEWPAARTARFSVLDPFSKALAVPAGSSQFDLVIIRRPQHADLGELDILVGNLRRLTSDGGSVIFYDSKQSSLSGGRGLANGHNHFPAALQRFGLTKVRQTRDGSCIVAEVSPAQNLSLRNDFRVVIVRFSTARSTIIDHTISQLRQFGWTLTEICIYNESGTGLPQLPPKSTVLVLDELDRPLLATATDHEWTALQAIIQSECNLLWVTEGSQVRPTAPLKAVAHGIFRTVRAEVPMMRIVTLDVESATTESLGTNASAINMALREITLADRSSLPIECEIAERGGLLHVSRIWPDAGVNKRKVEDNAGGAPPVLTNLHDSKSTIRLMASRPGSLEALHFAEQGRDVCSRQDMGPDDVEVEIFAAGCNSRDIDVAMGDISGDLDGLGLEGAGVVVRVGACVSARCVGQRVAVFGKGCFANRVTVSCKATFPLPDAMSFEQAATLPIALLTALYAVGRLAHVQGDDRVLVHSPCTDVGIACIRLCQRSGSTPFATVDNLEQRHFLTHELGLPEDHIFMSEPAAFPRALRHATKGHGLDVIISQPANRNLDNENMRLLAPGGRLIGIANGGADVGNLLPTGSLAPNCSFQRLDVTALPEKTIESVFLELSRLVTDGSVQPLSPSTLLGYEEIPKALQLLREGTHIGKIVISDPRGTKLAVLTRPATTLAQSMINPSHCYLLVGGLKGICGSLAIHLASHGAKNIAVMSRSGGGDQVSQGIARNIRALGCSLDLLQGDVTSISDVRRAFSQISVPLGGIIQGAAVFRDRTFESMSHEDYHAAVSSKVTGTCNLHTVSLETNQPISFFTMLSSISGVIGQKGQANYAGGNAFQDAFAEYRRALGLPAISIDLGPVEDVGVIHGNEDLQNRFDGSTLLSINEGLLRRIFDYSILQQHPDPQHRLNVTSQGQMITSILVPQPEDSDLLRDCRFRGLRALGEHSPRSRRDPTKDKEIQSLLFLAQSQDPDRAALRAAAITVVGARLAKQLRLTDAVDPARPLSYYGLDSLAAVELRTWVRMTLAIELTTLDVMNAASLGELCEKVIGKMGFGM
What is the function of this protein?
Dodecapentaenoate synthase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:23488861, PubMed:24568283).  Within the pathway, the polyketide synthase af370 produces the dodecapentaenoyl group of fumagillin via the condensation of one acetyl-CoA starter unit and 5 malonyl-CoA elongation units (PubMed:23488861).  The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520.  The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps 5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene.  The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin.  Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (PubMed:24568283) (Probable).
What are the official names of this protein?
Fumagillin dodecapentaenoate synthase af370, Fumagillin biosynthesis polyketide synthase, Fma-PKS.