PharMolix/UniProtQA huggingface dataset:
Protein: DPO4_STRPG
Sequence: MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPALKGKPVVIGKDPRETGGRGVVSTCNYEARKYGIHSAMSSKEAYERCPKAIFISGNYEKYRTVGDQIRRIFKRYTDLVEPMSIDEAYLDVTDNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKFLAKLASDFEKPHGLTLVLKEDALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLAVPEMTLIDHFGRFGFDLYRKARGISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEISKNAKRVAALLQDHKKLGKTIVLKVRYADFTTLTKRVTLPELTRNAAQIEQVAGDIFDSLSENPAGIRLLGVTMTNLEDKVADISLNL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VHP1_CAEEL
Sequence: MTVLDTVTISTCGLAALIREAPDTTLVVDCRGFTEYNESHVRHSMNAFFSKLIRRRLFENKLDDNCLIHQLMSCSSGCTKMDEKLDLVLYAEEDKPRGNKRRIASCNAPESTAKIMRVLRERLEDTDKFRSVMVLEGGFKQFAQQYPQLCESSEGMTRLPQSLSQPCLSQPTGDGITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDHVLDYNQASRPHRHMDYYGPSDLCPPKVPKSASSNCVFPGSTHDESSPSSPSVSEGSAASEPETSSSAASSSSTASAPPSMPSTSEQGTSSGTVNVNGKRNMTMDLGLPHRPKALGLPSRIGTSVAELPSPSTELSRLSFNGPEAIAPSTPILNFTNPCFNSPIIPVASSSREVILTLPTPAASSSSSTSSEPSFDFSSFESSSSSSIVVENPFFASTEVPAGSSSISTPSGSQSTPASASSSAASRCRMKGFFKVFSKKAPASTSTPASSTPGTSRAARPECLRSSGIIISAPVLAITEEEDAESPESGFNEPEVGEEDDDSVSICSTSSLEIPCHQ
What is the function of this protein?
Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs.  Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways.
What are the official names of this protein?
Tyrosine-protein phosphatase vhp-1, Vh1 dual specificity phosphatase family protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Protein: A1_BPT5
Sequence: MVISAEKQTVILKMAADFNFYGKRLRATKLEVCDDISKMVYDTTKHSTAICDWLEANKPAKPKAAKVAKAIKNDERPEAAGIVSSTVEQWEVKQGKRFIITSIQNNTFPHKNFLASLEQYAQFIGADLLVSKFIYNKNGFQNGEGADGIRYDSAFDKYICNKNVFLNNRRFAFMAEINVLPTADYPLSGFAETATALNLEGLAIGAAKITAESVPALKGEIVRRMYSTGTATLKNYIQQKAGQKAEALHNFGALIVEFDEDGEFFVRQLETMDESGVFYDLNTCATPAGCYETTGHVLGLQYGDIHAEKLDEECAAASWGHGDTYGLVDILKPKYQFVHDVHDFTSRNHHNRASGVFLAKQYAAGRDKVLDDLIDTGRVLESMERDFSQTIIVESNHDLALSRWLDDRNANIKDDPANAELYHRLNAAIYGAIAEKDDTFNVLDYALRKVAGCEFNAIFLTTDQSFKIAGIECGVHGHNGINGSRGNPKQFKKLGKLNTGHTHTASIYGGVYTAGVTGSLDMGYNVGASSWTQTHIITYANGQRTLIDFKNGKFFA
What is the function of this protein?
Involved in the degradation of host DNA and the shutoff of host genes and phage pre-early genes.  Together with A2 protein, involved in the second step transfer (SST) of viral DNA into the host cell, which leads to the complete entry of viral DNA into the host cell.
What are the official names of this protein?
Protein A1.
Protein: RL15_ECOLI
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEIRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
This protein binds the 5S rRNA.  It is required for the late stages of subunit assembly, and is essential for 5S rRNA assembly onto the ribosome.
What are the official names of this protein?
50S ribosomal protein L15, Large ribosomal subunit protein uL15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GLND_PASMU
Sequence: MLFPYFPLSELDVSAVRTQKENLKQFELTQFAHYEIYDLITNRTQFCDHLLRDLWLRFGLVKDNTLTLIAVGGYGREEMFPLSDLDFLILTSEQVEAQTEQKIRQFVQFLWDCGFDVGHAVRTLSECEQAGRDNITVATNLLEARYLEGNFSQFQQLDNVLQKADFWPREAFFQAKYQERVERYQRYHNTSYNLEPDIKHSPGGLRDLHLLYWIALRHTGAKNLTDILNSGFIYPQEYAQLLESQQFLFKVRFALHLILKRYDNRLLFERQIRVAELLEFVGPGNQGVEKMMKSFFQALQTISLLSDLLVKHYREHFLQTNEPVQVRLLDKEFQCVNNAICLRQANLFVEQPEQILSLFFHLTQDHQLDIHSSTLRQLHLALEQRSGYLSELPVARERFLRLFNQPGAIARALVPMHKYGVLKAYLPQWHHIEGLMQFDLFHCYTVDEHIVRTLLKLEYFLEAESVVPHPICSQIFSRLTDRTLLYIAALFHDIAKGRGGDHAELGAVDVAQFAQQHGFDQREIHTLTWLVEQHLLMSVTAQRRDIHDPEVVLHFAEAVQNNVRLDYLTCLTVADICATNETLWNSWKRTLIATLYQFTTQQFAQGMDCLLDHAEKIENHRQQALTLLTQNSLLSAVQIEEIWQHCPEEYFLRNTPKQIAWHTELLADNQTELLVKISNRFSEGGTEIFVYCQDQPNLFHKVVTTIGAKKFSIHDAQIITSHDGYVFDSFIITELDGKLVKFDRRRSLEKALMQALNTSKLPTFRATDNPKLQHFHVKTEVRFLKEQRTDQTEMELFALDQTGLLAKVSQVFSELKLNLLNAKITTIGEKAEDFFILTNSEDRALTAEQRQCLTQRLHEVLEPK
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: RL20_CORU7
Sequence: MARVKRSVNAKKKRREVLNSAKGYRGQRSRLYRKAKEQMLHSKTYAFRDRRARKGEFRKLWIQRINAAARQNDMTYNRLIQGLKLAEIEVDRKVLAELAVSDAAAFTALCEAAKAALPEDVNAPAAS
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SPC25_ASPOR
Sequence: MASSFEPSLSTSGMRPPLTSADAPSMADSLPSINFGFEDLRNRMAQFTARFDAFIEKGRKQILEERNQFKIGLAELQEDQRMKQRDIEILNLKSQTHDQTIQKEAAEAAEMHGTIASVTMERDSRLAKRDRLKQQINETQKAINQKLEAQKAHARHLDAQARLNIPELEFWQDYLCLRIEGAGREDRLKFIFSHLLEKDWEAEAWFELGTSSRDYDVFHTRPKVDRDALNGELDILNEDRDFGAFLKRMRRLLVEKMQQKRPTI
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Probable kinetochore protein spc25.
What is the protein family that this protein belongs to?
Belongs to the SPC25 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Protein: Y1015_HAEIN
Sequence: MFGLPIPIIGLLIAVFVLVFLVLRTRVHAFIAMLIAASIAGLVGGMSADETLNSITKGFGGTLGSIGIVIGLGVMMGSVLEVSGAAEKMAYSFIKMLGQKKEEWALAITGYVVSIPIFVDSAFVILYPVAKALAKNGKRSLLTLGVALAGGLAVTHHTVPPTPGPLGVAGLFGVDIGAMLLTGMCMAFLPVVGIVLYAKWLDKKYPNFNQEVFTEEELKQKYDSYIESREKKELPSLGLSLLPIVLPIVLIFIKAVVHLFVKDVPEALTSIPYQIVSFLGHPVIVLALSVLISVYTLLPKADKNTTALHLEEGVKTAGIILLVTGAGGALGAVLRDSGAGKQLAEQIANLPISPILIPFIVSTLVRFIQGSGTVAMITAASISSPILAQIPGVNMLLAAQAATMGSLFFGYFNDSLFWVVNRMMGINDVKKQMVVWSVPTTIAWGIGGISVILANLIFGNDGSVFDLLFPVVVLASILFYIKLQNKNL
What are the official names of this protein?
Uncharacterized permease HI_1015.
What is the protein family that this protein belongs to?
Belongs to the GntP permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYFA_RICAE
Sequence: MENIETILRLAEDKILLVQNLKALQEYKVEFLGKNGIVTGELKKLGSLNEQERKEFGLKINKLKDKIQNIIKAKAEILEEQELNFKLAADKIDLTIPARRYKQGSIHPITQCSEELIQVFSQFGFTIENGPNIENDFYNFTALNFEDDHPARQMHDTFYLKSQENNKPLLLRTHTSTVQIRAMKNGKPPFRFIAPGRTYRSDSDMTHTPMFHQIEGLVMDKNINMGHLKYVITTFIKSFFENSNIELRFRPSFFPFTEPSSEVDIRMNKNDKWLEVLGCGMVHPNVLKNVGIDSSEYQGFAFGLGVERFAMLKYNIKDLRQFFEGDMRWLKHYNFGSFDIPNLAGGLTK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KANL3_RAT
Sequence: MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPAPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMTGAVRSKVLEIHSHFPHKPIILIGWSTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDVARRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKGTTVTSAQKSSQIGTSQLLRRHVQRTDAVLTHRQAQVPISSEPVEEVEKEELRVQLKRHHPSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGVTASAAPSVASSNATPNAIHTLQSRLVATSPGSSLPGAASASSLLQGLSFSLQDISSKTTGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLAATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAASEEPNSQMLPSSSQRLPPAP
What is the function of this protein?
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
What are the official names of this protein?
KAT8 regulatory NSL complex subunit 3, NSL complex protein NSL3, Non-specific lethal 3 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: ANKUB_MOUSE
Sequence: MRIFIAFEGSFEAFDVEAHTSVGAIKQMIKDYFHIPLSEDKQGRWYLELMYAGAALRNSWSLSDVGISFCSTLKCFVKKEDKPTLYVFNAVTQEMMPIMENMSLLDKKVSDLRMLVTLRCGFPVSVYCLRTPTGLEMYDCNTLKDYQTDIGTTLRLDVWDGWKEFLMGCLLGQKPKVQHYLSKEGPVLKYGS
What are the official names of this protein?
Protein ANKUB1, Ankyrin repeat and ubiquitin domain-containing 1.
Protein: VMT9_MYXVL
Sequence: MSRTLLRFLEDGAMSDVTVVAGDSTFLGHKVILSLHSDYFYRLFNGDFTSPDTVTLDATDDAVRTVFTYMYAGCDGLNDRTIDDLQSIIVLADYLGITKLVDECVRRIVSKVDVLNCVGVYTFAETYHITDLQRAAKTFLTELLGSKEAFEELSQDDAVIALRETRNIVDRRSILRAILLWVRKCPDRIEQLKVLVAAVDDVDDDDNVYTIYERYAEELKDMIACPLSYNCVVVVDRDRYVRLINPDTLWSKRVTYIRKRAIGDRFTVVCMNNVLYCLGGTLDGAPTCDVLAYDLLTNEYSLMPEMGHYRRNASACIVNGYIYVVGGVDEENRLIGSVEYWQPGMEEWHDAPYLQANVETATVCYRNELWIVGGTVDLYHPTFISAVKKLTDNRWMSMEPLPEPRSGATTVVYNNRLYCIGGRIHGGAYTNHVYNYLDESRTWERVGDMANVRRNPSCCVYNKAIYVLGGNTNAVEKYNGWKWQEVGNISTYPACNNTAYPFFYTNDEI
What are the official names of this protein?
Kelch repeat protein M-T9, M9-R polypeptide.
What is the protein family that this protein belongs to?
Belongs to the poxviruses Kelch family.
Protein: BT3L4_MOUSE
Sequence: MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLKKLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGILSQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDDDVPDLVENFDEASKNEAN
What are the official names of this protein?
Transcription factor BTF3 homolog 4, Basic transcription factor 3-like 4.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
Protein: TLC2_CHLMU
Sequence: MSSEVKTFSKFRRYFFPIHKSEFPKFIPLLLLAFFVGFNYSLLKTTKDSLVLAGSRAGAEVIPFLKVWGIVPGAVIITMIYGWMSCRYSRGFVFCALVGGFLSFFALFACVIYPMGDALHLNGLAAKLQTILPRGARGFVVMVQYWSYSLYYVMSELWSSVVLSTLFWGIANHITSVREAGRFYALINVGLNVSSIVAGEISLWLGKHTLIPSSMAVDAWHGVLLNITLLIVAAGGLILYLYRKLDHLTEEAPVLGDGLVSEMSVAQLKQEKKRPKAKAKSLLSVLFRSRYLMGIAVVVLAYNLAIHLLEVVWKEQVCQIYSSRVEFNSYMSRITAFTGIVSALAGVFAAGQSIRRWGWTVGALITPLTMLITGGLFFGAIYAVKGDAMILGGFLGFSPLVLTAWLGGVQNVFSRAIKFTYFDQTKEMAFIPLEDDEKDYGKAAIDGVISRVGKSGGSLVYQALLIIFSSVADCMNAITIVLLLALGGWIWVVAWLGKEYSVRTAALGKARAAEEPSLQDEDESRVSSPISEPEAREEVVTTL
What are the official names of this protein?
ADP,ATP carrier protein 2, ADP/ATP translocase 2.
What is the protein family that this protein belongs to?
Belongs to the ADP/ATP translocase tlc family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DEF25_ARATH
Sequence: MASLKVFSFALILVLTFSVDVEGYNVESGGSLCCNNHPKFGKCNTNNDNQRCNRWCHNGCGNGKGDYCKAMSHGGLCHCYC
What are the official names of this protein?
Putative defensin-like protein 25.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: GVPA_ANCAQ
Sequence: MAVEKINASSSLAEVVDRILDKGVVVDAWVRVSLVGIELLAVEARVVVAGVDTYLKYAEAVGLTASAQAA
What is the function of this protein?
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms.  They allow the positioning of the organism at the favorable depth for growth.  GvpA type proteins form the essential core of the structure (By similarity).
What are the official names of this protein?
Gas vesicle structural protein, GVP.
What is the protein family that this protein belongs to?
Belongs to the gas vesicle protein type A family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle membrane.
Protein: GAR4_HUMAN
Sequence: MNADFLLPYYTAQSGSSMSMFNTTMGKLQRQLYKGEYDIFKYAPIFESDFIQITKRGEVIDVHNRVRMVTMGIARTSPILPLPDVMLLARPATGCEEYAGHGQATKRKKRKAAKNLELTRLLPLRFVRISVQDHEKQQLRLKFATGRSCYLQLCPALDTRDDLFAYWEKLIYLLRPPMESNSSTCGIPAEDMMWMPVFQEDRRSLGAVNLQGKGDQDQVSIQSLHMVSEVCGATSAAYAGGEGLQNDFNKPTNVLNASIPKTSTELAEEPATGGIKEAAAAGAAAGAATGTVAGALSVAAANSAPGQVSAAIAGAATIGAGGNKGNMALAGTASMAPNSTKVAVAGAAGKSSEHVSSASMSLSREGSVSLAIAGVVLTSRTAAEADMDAAAGPPVSTRQSKSSLSGQHGRERTQASAEGCKEGRERREKDRALGRSSHRRRTGESRHKTRGDKIAQKSSSRSSFSHRANRDDKKEKGCGNPGSSRHRDSHKGVSHTPISKESRTSHKSGRSLWTTSSGSSKGLGRVSSFLRNVRANLTTKVVGTPHGRDVNVMAKMAERSTNVAIAETAEGGQGLETVGSMTPDIMETVTFEAH
What is the function of this protein?
RAB2B effector protein required for the compacted Golgi morphology, probably through interaction with small GTPase RAB2B.
What are the official names of this protein?
Golgi-associated RAB2 interactor protein 4, Golgi-associated Rab2B interactor-like 4, GARI-L4, GARI-like 4.
What is the protein family that this protein belongs to?
Belongs to the GARIN family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: MAP1_MIZYE
Sequence: QSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEPEDGENLYVKLNNLVDGHYKFHNLHVHNGRTRRKGSEHSVNGRFTPMEAHLVFHHDDQTHFEPTRTKLGGAFPGHNDFVVVGVFLEVGDDGFGDEPDDEECKRILKGHHPDNNENGNGDNGNNGYNGDNGNNGDNGNNGYNGDNGNNGDNGNNGYNGDNGNNGDNGNNGENGNNGENGNNGENGNNGENGHKHGCRVKKAKHLSTILECAYRNDKVREFKKVGEEEGLDVHLTPEMPLPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHALRNVEGY
What is the function of this protein?
Acts as a negative regulator for calcification in the shells of mollusks.  May function both as a calcium concentrator and as a carbonic anhydrase required for production of carbonate ions, which are assembled to CaCO(3) at mineralization sites.  Is important for shell formation in both the calcitic prismatic layer and the aragonitic nacreous layer (By similarity).  Shows inhibitory activity of crystal formation when present in free state but, when attached to the insoluble matrix, may regulate the form and size of aragonite crystal.
What are the official names of this protein?
Nacrein-like protein P1.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: HEM1_DEIGD
Sequence: MPPLAPLDFAVIGLNHQTAPVEVREQAAVRAGDEGKVLQHLSRYAREVMLLNTCNRTEVYLAGLQGDPLRAFESGWGRALDGHLYVHRGEAAATHLYRVAAGLDSLVIGETQIQGQVKRAWQEAHARGLSGTLLNKVAQGALAAGKRVRSETGLSDKVVSVSSAAVELAEAALGELRHRTALILGAGETAELTLTHLRAAGVQDVIVVNRTEARARQLADKLGGRACAAEYLHEVLPEADVVIASSAAPHYVLHGEGVRAALAKRPERPIFLIDISVPRILDPDIRAVSGAHLYNLDDLTAIVSRNLQSRRAALPYAEAIIREAVADLLRWHLTREAQLGRRAVALASD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PMM2_MACFA
Sequence: MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCKQNIQSHLGEALIQDLINYCLSYIAKVKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTVGYSVTAPEDTRRICEELFS
What is the function of this protein?
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
What are the official names of this protein?
Phosphomannomutase 2, PMM 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic PMM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_STRA1
Sequence: MAVPARHTSKAKKNKRRTHYKLTAPSVQFDETTGDYSRSHRVSLKGYYKGRKIAKANEAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RS9_PARMW
Sequence: MSSNSVVYWGTGRRKTSVARVRLVPGNGTITINGRPGDNYLNYNPAYIAAVKAPLETLGLGTEYDILVNVHGGGLTGQSGAIKQGAARALCELSADNRKPLKTEGHLSRDPRAKERRKYGLKKARKAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: KDSA_PSEPW
Sequence: MIKITQNIECSNAAPFVLFGGINVLESEDLALTACAEYVRVTEKLGIPYVFKASFDKANRSSIHSYRGPGMEEGLRIFEKVKAEFGVPIITDVHEIYQCAPVAEVVDVLQLPAFLARQTDLVVALAKTGKPVNIKKPQFLSPSQMQNIVQKFKEAGNDQLILCDRGTCMGYDNLVVDMLGFGVMKRTCDDLPIIFDVTHALQNRDPSGAASGGRREQVVDLARAGMGVGLAGLFLEAHPNPDQAKCDGPSALPLDKLEPFLAQIKALDDLVKSFPPLVIG
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHTC_SALTY
Sequence: MMMLFFTVAMVHIVALMSPGPDFFFVSQTAVSRSRKEAMMGVLGITCGVMVWAGVALLGLHLIIEKMAWLHTIIMVGGGLYLCWMGYQMLRGALKKQDAAASSPHIELAQSGRSFLKGLLTNLSNPKAIIYFGSVFSLFVGDNVGAAARWGIFALITLETLAWFTVVASLFALPKMRRGYQRLAKWIDGFAGALFAGFGIHLIISR
What is the function of this protein?
Conducts the efflux of threonine.
What are the official names of this protein?
Threonine efflux protein.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARNT_ESCF3
Sequence: MKSARYILAFIAFIALYYFLPMNTRLLWQPDETRYAEISREMLASGDWIVPHMLGLRYFEKPIAGYWFNSIGQWLFGNSNFAVRAGVIFATLITALLVAWFAMRLWRDKRLAVLSAVIYLSLIIVYGIGTYAVLDPFIAFWLMAGMCSFWLAMQAQTWKGKSAGFLLLGLTCGMGVMTKGFLALAVPVLSVLPWVVAQKRWKDLFMYGGLAIVSCVLIILPWGLAIAAREPDFWHYFFWVEHIQRFAQDDAQHKAPFWYYIPIILLGSLPWLGLLPGALRSGWQNRGHHAAAFYLLCWIVMPLLFFSMAKGKLLTYILSCFAPLAILMAGYGIQSAQKNIIALRFNGWINIAFGITGIIATFVVSPWGPIKSPVWAHFESYKVFCSWAIFSLWAFFGWYTLTDSEKRWPYAALCPLGLALLVGFAMPDRVRESKQPQFFVGMTSEMLKPSRYILTDSVGVAAGLAWSLQRDDIMLYQQRGELKYGLDYPDVKDKFIPAASFTSWLNQHRQEGIITLVLSVDRDEDINRLAIPPADAVDHQGRLVLIQYLPK
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL1_THEP1
Sequence: MPKHSKRYLEARKFVDRTKYYDLDEAIELVKKTATAKFDETIELHIQTGIDYRKPEQHIRGTVVLPHGTGKEVRVLVFAKGEAAKEALEAGADYVGAEDLVEKIEKEGFLDFDVAIATPDMMRVIGRLGKILGPRGLMPSPKSGTVTQEVAEAVKEFKKGRIEVRTDKTGNIHIPVGKRSFDNEKLKENIISAVRQIMQMKPAGVKGQFIKKAVLSSTMGPGIKLNLQSLLKE
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: AQP4_MOUSE
Sequence: MSDGAAARRWGKCGHSCSRESIMVAFKGVWTQAFWKAVSAEFLATLIFVLLGVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGEEKKGKDSSGEVLSSV
What is the function of this protein?
Forms a water-specific channel (PubMed:8660998, PubMed:9276712, PubMed:18286643).  Plays an important role in brain water homeostasis and in glymphatic solute transport (PubMed:22896675, PubMed:27751903, PubMed:30561329, PubMed:30557661).  Required for a normal rate of water exchange across the blood brain interface (PubMed:30557661).  Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways.  Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP (PubMed:22896675, PubMed:27751903, PubMed:30561329).  Plays a redundant role in urinary water homeostasis and urinary concentrating ability (PubMed:9276712).
What are the official names of this protein?
Aquaporin-4, AQP-4, Mercurial-insensitive water channel, MIWC, WCH4.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endosome membrane. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane (By similarity). Detected on brain astrocyte processes and astrocyte endfeet close to capillaries (PubMed:22896675).
Protein: CH602_RHIEC
Sequence: MAAKEVKFHSDARERMLRGVDVLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQMLREVASKTNDLAGDGTTTATVLAQAIVKEGAKAVASGMNPMDLKRGIDLAVDAVVGELKANARKISNNSEIAQVGTISANGDAEIGRYLAEAMEKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNQDKMRVELEDPYILIHEKKLSNLQSMLPVLEAVVQSGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTAGTVISEDLGIKLENVTLNMLGRAKKVAIEKENTTIIDGAGSKAELDGRTAQIRAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALHATRAAVEEGILPGGGVALLRAVKALDSIKTANDDQRVGVDIVRRAIEAPVRQIAENAGAEGSIIVGKLREKSDFSYGWNAQTGEYGDLYAQGVIDPAKVVRTALQDAASVAGLLVTTEAMIAEKPKKEAAPAMPAGAGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.