PharMolix/UniProtQA huggingface dataset:
Protein: HSPB6_MOUSE
Sequence: MEIPVPVQPSWLRRASAPLPGFSAPGRLFDQRFGEGLLEAELASLCPAAIAPYYLRAPSVALPTAQVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPAAK
What is the function of this protein?
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state.  Seems to have versatile functions in various biological processes.  Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility.  May regulate myocardial angiogenesis implicating KDR.  Overexpression mediates cardioprotection and angiogenesis after induced damage.  Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
What are the official names of this protein?
Heat shock protein beta-6, HspB6.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Note=Translocates to nuclear foci during heat shock.
Protein: AI3_KLULA
Sequence: MNIIIIILYISYIYTYPFSNGKYCNLYNPTTFYKINNILYSIKIYNINNNTNNTNNNNPADSSSYESRMRAAGNSNSNSNSNSDSNINNTNNINNTNNIYNINNNINNNNNINNNYINNSIPCGSYPQGRWTAGSEFYKMLFVGLFDSNGNIQINKYKSKYLQFRLIIKLNNNKENINILNNIKHYLKGNININNNYVIWIINDIKNINNLIKLFNKYPLITINKKLQLAFIKSIYYIYKNNRNLAINLYLKDRNNKYNPNLYKYYKDINYTKINYFSPANFHKKFAGININININNNYNHNYINVWFLGFIENKGKFIIRKNNNNSFLFYINDKHLIEFLKNYFNIKNKLIYKNNIYILEVYNKYYINIFIKFFNKYNLQGYKYIEYIKWKKINI
What is the function of this protein?
Mitochondrial DNA endonuclease involved in intron homing.
What are the official names of this protein?
Probable intron-encoded endonuclease aI3.
What is the protein family that this protein belongs to?
Belongs to the LAGLIDADG endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MNME_THEMA
Sequence: MDTIVAVATPPGKGAIAILRLSGPDSWKIVQKHLRTRSKIVPRKAIHGWIHENGEDVDEVVVVFYKSPKSYTGEDMVEVMCHGGPLVVKKLLDLFLKSGARMAEPGEFTKRAFLNGKMDLTSAEAVRDLIEAKSETSLKLSLRNLKGGLRDFVDSLRRELIEVLAEIRVELDYPDEIETNTGEVVTRLERIKEKLTEELKKADAGILLNRGLRMVIVGKPNVGKSTLLNRLLNEDRAIVTDIPGTTRDVISEEIVIRGILFRIVDTAGVRSETNDLVERLGIERTLQEIEKADIVLFVLDASSPLDEEDRKILERIKNKRYLVVINKVDVVEKINEEEIKNKLGTDRHMVKISALKGEGLEKLEESIYRETQEIFERGSDSLITNLRQKQLLENVKGHLEDAIKSLKEGMPVDMASIDLERALNLLDEVTGRSFREDLLDTIFSNFCVGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP5_ROTRF
Sequence: MSLSIDVTSLPSISSSIYKNESSSTTSTLSGKSIGRSEQYISPDAEAFSKYMLSKSPEDIGPSDSASNDPLTSFSIRSNAVKTNADAGVSMDSSTQSRPSSNVGCDQVDFSFNKGISMNANLDSSISISTSSKKEKSKSDHKSRKHYPKIEAESDSDDYILDDSDSDDGKCKNCKYKRKYFALRMRMKQVAMQLIEDL
What is the function of this protein?
Plays an essential role in the viral genome replication.  Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories.
What are the official names of this protein?
Non-structural protein 5, NSP5, NS26.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP5 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RECR_MARSD
Sequence: MENLPEPLRVVAQELAKLPGLGPKSALRIALTMLKMPKEKVTGIGQSVIDLREKLCICEQCASITDTCPCRICSDPKREHDKLCLVSEWDSLLAIEEMGLYRGYYLVLGGLLSPLDGVTPQHLEFQKLEERLEKGEVKELILALGATVDAEATASYIKNMVESKYPGIELSRLAQGIPIGSEVKYTDKETLRQSLEYRQKL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: ATPF2_RHIE6
Sequence: MFFVTPAYAEEAPAAATGTDAHAAPAAGEVHTETGVAEGEHARGPFPPFDSTTYASQLLWLVITFSVFYLLMQKVIAPRIGAILDQRHTRISQDLEEAGRLKAEADAAVQTYEGELAAARAKSNAIGSAARDAAKAKAEEDRRAVEASLSEKIKAAEVRIADIKAKAFADVGTIAEETAAAVVEQLIGGTAAQADVAAAVAAAKKEA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria (By similarity).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MRAZ_XANCB
Sequence: MFQGETAITVDDKGRMAVPTAYRDLVARVSGNRLVLTYNPFEAGCLWLYAEKEWERVRDDVMSKPNTQRVVRTLQQKLVGSSAVLELDANGRLSIPASHRNAVGIEKKAVLLGMGDKFELWSEQAHRALIQQTLSDGDLGDELLDLRL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: METAS_ECO7I
Sequence: MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEYFRDVEAGLDPEVPYNYFPHNDPQNKPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSR_ECO57
Sequence: MATMKDVARLAGVSTSTVSHVINKDRFVSEAITAKVEAAIKELNYAPSALARSLKLNQTHTIGMLITASTNPFYSELVRGVERSCFERGYSLVLCNTEGDEQRMNRNLETLMQKRVDGLLLLCTETHQPSREIMQRYPTVPTVMMDWAPFDGDSDLIQDNSLLGGDLATQYLIDKGHTRIACITGPLDKTPARLRLEGYRAAMKRAGLNIPDGYEVTGDFEFNGGFDAMRQLLSHPLRPQAVFTGNDAMAVGVYQALYQAELQVPQDIAVIGYDDIELASFMTPPLTTIHQPKDELGELAIDVLIHRITQPTLQQQRLQLTPILMERGSA
What is the function of this protein?
Transcriptional repressor for the ribose rbsDACBK operon.  RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site.  The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon (By similarity).
What are the official names of this protein?
Ribose operon repressor.
Protein: PTN7_MOUSE
Sequence: MVQACEGRSRAQLPTLSLGADMTQPPPTKAPAKKHVRLQERRGSSVALMLDVQSLGTVEPICSVNTPREVTLHFLRTAGHPLTRWTLQHQPPSPKQLEEEFLKIPSNFVNPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDSDYINANYIRGYDGKEKVYIATQGPMPNTVADFWEMVWQEDVSLIVMLTQLREGKEKCVHYWPTEEEAYGPFQIRIQDMKEHPEYTVRQLTIQHQQECRSVKHILFSAWPDHQTPESAGPLLRLVAEVETPETAANSGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAAQLPPEPNP
What is the function of this protein?
May play a role in the regulation of T and B-lymphocyte development and signal transduction.
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, HEPTP.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Oxidized form is preferentially associated with actin cytoskeleton.
Protein: ISCS_SHEPW
Sequence: MKLPIYLDYAATTPVDPRVAEKMMQCMTMDGIFGNPASRSHRYGWQAEEAVDIARNQIAELINADPREIVFTSGATESDNLAIKGVAHFYQKKGKHIITSKTEHKAVLDTCRQLEREGYEVTYLQPEANGLIPVAMIEAAMREDTLLVSIMQVNNEIGVIQDIDAIGELCRSRKIVFHVDAAQSAGKMPIDVQKTKVDLMSISAHKMYGPKGIGALYVSRKPRIRLEAAMHGGGHERGMRSGTLATHQIVGFGEAAAIAKTDMDSDNERIRRLRDKLWNGINHIEETYINGDMEQRHCGSLNVSFNFVEGESLMMALKDLAVSSGSACTSASLEPSYVLRALGLNDEMAHSSIRFSIGRFTTDEEIEHAIETITESIGNLREMSPLWEMFKDGIDLDSVQWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KRA43_HUMAN
Sequence: MVSSCCGSVCSDQSCGQGLGQESCCRPSCCQTTCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCRTTCCRPSCCISSCCRPSCCISSCCKPSCCQTTCCRPSCCISSCYRPQCCQPSCCRPACCISSCCHPSCCVSSCRCPFSCPTTCCRTTCFHPICCGSSCC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 4-3, Keratin-associated protein 4.3, Ultrahigh sulfur keratin-associated protein 4.3.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 4 family.
Protein: PAND_BACCZ
Sequence: MFRTMMRAKLHRATVTEANLNYVGSITIDEDLMDAVNIVENEKVQIVNNNNGARLETYVIKGERGSGVVCLNGAAARLVQPGDKVIIICYGLVAEENIHKQEPKIAVLDDDNQIIEMLGAEKAGTIL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_TRIEI
Sequence: MTKKTVASLSKSDLSGKKVLMRADFNVPVDNGSITDDTRIRAALPTIQDLTEKGAKVILTSHFGRPKGKVNEKMRLTLVGERLSEVLGKEVKKCDDCIGDEVTSTVAEMKDGDVVLLENVRFYSGEEGNDPEFAKQLASVADLYVNDAFGTAHRAHASTEGVTKYLSPSVAGYLIEQELKFLQGAIDSPQKPLAAIIGGSKVSSKIGVIEALLDKCDKLLLGGGMIFTFYKARGLSVGKSLVEEDKIELAKSLEAKAKEKGVTMLLPTDVVVADKFDPEANTQTVSIEAIPDGWMGLDIGPESAKVFQDALADCKTVIWNGPMGVFEMEKFAKGTEAIAQTLADKQDAITIIGGGDSVAAVEQLGLGEKMSHISTGGGASLELLEGKKLPGIVALDDQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WBP2_RAT
Sequence: MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVIFLSKGKDAMRSFMMPFYLMKDCEVKQPVFGANFIKGTVKAEAGGGWEGSASYKLTFTAGGAIEFGQQMLQVASQASRGEVPNGAYGYPYMPSGAYVFPPPVANGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVVSGPSAPPTPAAEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ
What is the function of this protein?
Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation.  In presence of estrogen, binds to ESR1-responsive promoters.  Required for YAP1 coactivation function on PGR activity.  Synergizes with WBP2 in enhancing PGR activity (By similarity).  Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
What are the official names of this protein?
WW domain-binding protein 2, WBP-2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus when phosphorylated.
Protein: NDK_CUPNH
Sequence: MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAAKMVHLSRGEAEQFYAVHKERPFFKDLVDFMVSGPVMIQALEGENAIAKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAAETAAVEVSFFFPGMNVYSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_RUEST
Sequence: MSGDLSPIDKAKFVAAKRAAELVEDGMRVGLGTGSTAAWLVRCLGEMVREDGLKITGVPTSARTAELAREVGIELITLDEARWLDLTIDGADEFDSELNLIKGGGGALLQEKIVATASDQMVVIADKAKEVETLGAFPLPIEVIPFGWQTSQALVEETLISMDVMGRSSTLRMNGASPYVTDEGNHILDLHLNRIGNPRQLALVLNQIPGVVENGLFIDICDTVVIGYGDGKVEVRDINEGTIETDRIDFVETDNLFADLND
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: CELF2_XENTR
Sequence: MMVDSRLLVSDRINGTTNKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKDLFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGALTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATTTNANPLSTTTSALGALTSPVAASTANSSAGAAMNSLTSLGTLQGLAGATVGLNNINALAGTVNIAQMLSGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY
What is the function of this protein?
RNA-binding protein implicated in the regulation of several post-transcriptional events.  May be involved in pre-mRNA alternative splicing, mRNA translation repression and stability (By similarity).
What are the official names of this protein?
CUGBP Elav-like family member 2, CELF-2, Bruno-like protein 3, CUG triplet repeat RNA-binding protein 2, CUG-BP2, CUG-BP- and ETR-3-like factor 2, ELAV-type RNA-binding protein 3, ETR-3, RNA-binding protein BRUNOL-3.
What is the protein family that this protein belongs to?
Belongs to the CELF/BRUNOL family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GLYCO_WCBV
Sequence: MASYFALVLNGISMVFSQGLFPLYTIPDHLGPWTPIDLSHLHCPNNLYTDASYCTTEQSITYTELKVGSSVSQKIPGFTCTGVRTESVTYTNFVGYVTTTFKKKHFPPKSRDCREAYERKKAGDPRYEESLAHPYPDNSWLRTVTTTKDSWVIIEPSVVELDIYTSALYSPLFKDGTCSKSRTYSPYCPTNHDFTIWMPESENIRSACNLFSTSRGKLVRNRTSTCGIIDERGLFRSVKGACKISICGRQGIRLVDGTWMSFRYSEYLPVCSPSQLINTHDIKVDELENAIVLDLIRRREECLDTLETILMSGSVSHRRLSHFRKLVPGSGKAYSYINGTLMESDAHYIKVENWSEVIPHKGCLMVGGKCYEPVNDVYFNGIIRDSNNQILIPEMQSSLLREHVDLLKANIVPFRHPMLLRSFTSDTEEDIVEFVNPHLQDTQKLVSDMDLGLSDWKRYLLIGSLAVGGVVAILFIGTCCLRCRAGRNRRTIRSNHRSLSHDVVFHKDKDKVITSWESYKGQTAQ
What is the function of this protein?
Attaches the virus to host cellular receptor, inducing endocytosis of the virion.  In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane.  There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
What are the official names of this protein?
Glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: Y3178_CAUVC
Sequence: MIDLVFDARRKDLGNFEVGRVLPFHAHRMVGPFTFLDHMGPAAFQPGFPKSADVRPHPHIGLSTLTYLFEGEITHRDSVGSLAVIKPHEVNWMTAGSGITHSERFEGLREHGGRMDGMQAWVALPTEFEEIDPSFTHHEGPAELPYYENGGLKARLIAGEAFGAKSSVPVYSPLFYVHWELEPGVTAALPAEYPERAAYIAAGRVEVDGRELVEAQMAVFAPGETVVFKALERSTVMLLGGEPVGPRFIEWNFVSSSKDRIEQAKADWKAGRMKLPDLDHGEFIPLPE
What are the official names of this protein?
Pirin-like protein CC_3178.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
Protein: HEM1_GEOTN
Sequence: MQIIVVGVNYKTAPVEIREKLAFGEAELGEAMKQLAKQKSILENVIVSTCNRTEIYAVVDQLHTGRYYIKAFLAEWFDIEAEAIAPYLRVLEGEAAAGHLFRVAAGLDSMVLGETQILGQVKGSYLLAQEIGTSGTILNHLFKQAVTFAKRAHSETGIGAHAVSVSYAAVELAKKIFGHLNGKHVLIIGAGKMGTLAAQNLYGNGVGKVTVVNRTLEKAKQLAAQFDGEAKSLGELSCALLEADIVISSTGAKGYMLTKEEMAPLEKMRKGRPLFMVDIAVPRDLDPALAELETVFLYDIDDLQDVVAANLAERQKAAALIEEMIEGELVAFGQWLQTLGVVPVIAALREKALAIQAETMKSLERKLPHLSERDRKVLNKHTKSIINQLLRDPILQVKELAAGPNADEALQLFMKIFNIEDAVKAEQRSAQRAEVQLRDEQQAEAVRAARPSWQL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: UVRB_ALIF1
Sequence: MSSAYELVSNYQPAGDQPQAIKTLNEGLENGLAHQTLLGVTGSGKTFTLANVIAHSGRPTIIMAHNKTLAAQLYGEMKAFFPNNAVEYFVSYFDYYQPEAYVPTTDTFIEKDSSVNEHIEQMRLSATKALLERKDAIIIASVSAIYGLGDPKAYLSMILHLRRGDIINQRDMLRRLAELQYKRNDMAFERGTFRVRGEVLDIFPAESEHEAIRIEMFDDEVERISKFDPLTGSIITKDMPRCTIYPKTHYVTPREQVLDAIEKIKVDLAIRQKELLENNKLVEEQRITQRTQFDIEMMNELGFCSGIENYSRYLSGRPEGEAPPTLFDYLPQDGLLIIDESHITVSQIGAMYKGDRSRKENLVEYGFRLPSALDNRPLRFEEFEALAPQTIYVSATPGKYEIEKSDGEIAEQVVRPTGLLDPVIEVRPVATQVDDLLSEIRIRTKNNERVLVTTLTKRMAEDLTEYLDEHGVKVRYLHSDIDTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLEGKAILYADKITGSMEKAIGETERRREKQQLHNETLGIVPQALKKDVADILELGDMTKNKRKVVAPKIKLSEVAEEGASYSAMSPQQLEKAIQKLESKMYQHAKDLEFEQAAQVRDEIDNLRKQFIVNS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLSA_CITK8
Sequence: MARAMDNSILETILQQVRPLIGQGKVADYIPALASVDGSKLGIAICTVDGQYYQAGDAQERFSIQSISKVLSLVVAMRHYPEEEIWQRVGKDPSGSPFNSLVQLELEQGIPRNPFINAGALVVCDMLQGRLSAPRQRMLEVVRALSGVSDIAYDVTVARSEFEHSARNAAIAWLMKSFGNFQHDVTTVLQNYFHYCALKMSCAELARTFVFLARQGQAFHLDEPVVTSMQARQINALMATSGMYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDPAGNSLAGIAVLEQLTQQLGRSVY
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: BR1_PELRI
Sequence: FFPAIFRLVAKVVPSIICSVTKKC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Brevinin-1R.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: MEOX1_DANRE
Sequence: MEQSASSCMRSPHTGGALWGCVRSPHSGGSGAGIQPYQQAPFALHQKHDFLAYTDFSSSCLVPAPHAYPREDRLYPETHSGYQRTEWQFSPCEPRGRGQEPCQGAAEAVGAEMDSAGGDRLAGAVTGCLEGDYSPQSVPAVDTEKKSSKRKREVTDIQDSSFKADSNCKARKERTAFTKEQLRELEAEFTHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQPASPHDLEADELDSAASPSSE
What is the function of this protein?
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development.  Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints.  Binds specifically to the promoter of target genes and regulates their expression.  Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.  Acts by mediating specification of endothelial cells of the endotome within the nascent somite, notably by repressing expression of cxcl12b.
What are the official names of this protein?
Homeobox protein MOX-1, Mesenchyme homeobox 1, Protein choker.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes predominantly in the nucleus.
Protein: GRPE_ALKCK
Sequence: MAEEKNEELQTEETEQTKEDGHGDSAEQEETENNSGTEVEEQEEPEVHPLEIELNELKDRLARVRADYENFRRRTKEEKEAQAKYRAQGFIEKLLPALDNFERALLVEPKHEEAKQLLQGMEMVYRQVEEALKQEGVEPIPTEGELFDPHLHQAVMQVSEEGYEPNQIVEELQKGYKLKDRVIRHSMVKVNQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_CLOD6
Sequence: MGKIIGIDLGTTNSCVAVLEGGEAQIIANSEGMRTTPSVVAFTKDGERIVGEPAKRQAVTNADKTITSIKTHMGTDYKVNIDGKSYTPQEISAIILQKLKSDAESYLGQTVTEAVITVPAYFTDAQRQATKDAGRIAGLDVKRIINEPTAAALAYGMDKLDQEKKILVFDLGGGTFDVSILEIGDGTFEVLATAGNNRLGGDDFDQIVIDYLAEEFKKAEGVDLRNDKMALQRLKEAAEKAKKELSSTMSSNINLPFITATAEGPKHLNIDLSRAKFEELTRGLVEKTMEPTKTALQDAGLSTGDIDDVLLVGGSTRIPAVQEAVKKFIGKEPHKGINPDECVAAGASIQAGVLAGDVKDLLLLDVTPLSLGIETMGNVMTKIIERNTTIPTKKSQIFSTAADNQTAVDIHVLQGERSMAYDNTTLGRFQLTDIPPAQRGIPQIEVTFDIDANGIVNVSAKDLGTGKEQKITITSNTNLSEAEIEQKIKEAEMNAEADKQKKEKIEAFNQAESTIYQTEKTLNELGDKISSGEKEDIEKAIADLKAVKDNQDATAEELKKATDEVMTKFQKVSQEMYQKAAQEQQAAQGAEQAQDNGPKDDNVVDADFKEVDEDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.