PharMolix/UniProtQA huggingface dataset:
Protein: Y2532_YERPB
Sequence: MIVYLHGFDSNSPGNHEKVLQLQFIDPDVRFISYSTLHPRHDMQYLLKEVDKAIQQGGDEKSLICGVGLGGFWAERIGFLCGIRQVAFNPNLYPQENMSGKIDRPEEYIDIASKCIDGFREKNRDRCLVVLSRHDEMLDSQRTAGDLHPYYEIVWDDKQNHKFKDLSPHLQRIKAFKTLG
What are the official names of this protein?
UPF0227 protein YPTS_2532.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: Y4503_RHIL3
Sequence: MSSPWSLFDDHLRLAVRLTPNGGRDALDGIEADGEGEAFLKARVTAVPEKGKANKALMLLIAKSLRIPKSSVSLVSGETARKKILRIDGDPEDLVKKLEIFLG
What are the official names of this protein?
UPF0235 protein RL4503.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: SUMT_SYNE7
Sequence: MTGKVYLVGAGPGDPEYLTLQAQQCLQSAEVLIYDALIDPRILDLVPANCDRIAVGKRGGAESTPQATINQLLVEHCQQGRKVIRLKSGDPFVFGRAASELDALERSGCDYAVLPGLSTALAAPLLAGIPITDPVLSRGFAVYTVHEPDALNWEALAQLETLILLMGSRHLLTIGHELIRHGRSPDSPVALIQWAGHPQQTVLESSLSRMAQQWGDQPLSPCVIVIGEVVRLRKYWAHYRYDG
What is the function of this protein?
Catalyzes the two successive C-2 and C-7 methylation reactions involved in the conversion of uroporphyrinogen III to precorrin-2 via the intermediate formation of precorrin-1.  It is a step in the biosynthesis of both cobalamin (vitamin B12) and siroheme.
What are the official names of this protein?
Uroporphyrinogen-III C-methyltransferase, Urogen III methylase, S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT, Uroporphyrinogen III methylase, UROM.
What is the protein family that this protein belongs to?
Belongs to the precorrin methyltransferase family.
Protein: VGFR3_DANRE
Sequence: MKRDFTFFCRIWIGIPFFSGLVNGFSMSPPTLDNTKDQLVINANDTLNITCRGQRILDWSWPEESLSKVEFTDRQGQQSPTDTPGYREIRLKECQGVAGKPYCKILILTNAQANDSGYYRCFYKDIKAVIDGTTAASIFVFVRDPEHPFIKRGDNDMETIFITDSETHIEVPCLVSDPDLKVTLFSLVPYPEPVDGSVVTWNNKKGWSIPRHIIQNTSTFIGFYCSISVQNSQHTSSIYVVQVIGLKFYEFKLFPEDSPVELMQGESLVLNCTALVDFNTGVDFQWDYPGKKENRLASLQPLRNVLDEATEISSILSIRNIHLDDSGYYTCWANTLEMKRELTTVVIVHEKPFISLDYRNGSVIEAKEGQKSVRLSVKVSAYPSPEIQWYKNGKLISSKNSSRFKVQQHSLQIRDVCKQDAGEYMLVLKNSPAALEKRLNFTLIVNVPPQIHEKEAAPPTNLYGKGTRQILTCTADGSPPASISWQWRPWSPCDLERTRRALRRRGGRDQSPFCHNWMDLDPEHAVNPIESIDTLTQMVDGKEKTVGRVVIQNASVPAMYKCLAENRVGKDERLIYFYVTTIPEGFDIEMEPSEDPLEQDLVQLKCNADNFTYENLRWYRLDPQTVPPELDCKSLHQYATFLEGQLSFQTTSNNWVLQLNITNIQLQDEGNYVCEVQNRRTGVKHCHRKYIPVKAMEAPRYRHNPTNHTVNVSESLQMNCDVEGTPFPQLSWFKDNQPLHQISGILLQDSNRTLSIQRVREEDAGLYTCSACNQKGCVQSSATVSVIGSDDKTNVEIVILIGTGVIAIFFWVLLLVIFCNVKRVNPADIKTGYLSIIMDPGEVPLEEQCEYLPYDSSQWEISRDRLRLGKVLGHGAFGKVIEASIFGHDKKSSANTVAVKMLKEGATASEHKALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEYCKYGNLSNFLRAKREFFLPYRDRSPKTQSQVRRMIEAGQASQSEHQPSTSSTNPPRVTVDDLWKTPLTIEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGNARLPLKWMAPESIFDKVYTSQSDVWSFGVLLWEIFSLGASPYPGIQIDEDFCKRLKDGTRMRAPDNASPEIYGIMLACWQGEPRERPTFPALVEILGDLLQENSLPEIPFNVSQSSEDDGFSQASSRPPSQEEIRLACNTLPTRYYNCVPFAGCVMVGPSSTCHSRVKTFEELPMEMTSHKTQHDSQTDSGMVLASDELERFEHKHRGAMLTTATTGQSTDRLISCPSVSSSGSGGGLLRPVFFTQLSGQTFYNNEYGHLSEEGVSDYFSSSDQAV
What is the function of this protein?
Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc.  Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo.  Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis.
What are the official names of this protein?
Vascular endothelial growth factor receptor 3, VEGFR-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization.
Protein: HIS4_BURP0
Sequence: MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILGEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACSAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLARKFEDYGVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNIVDIEKLCEVEDEGIEGVICGRAIYSGDLDFAAAQKRADELNGELDDA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMM_PSEAE
Sequence: MNTLLMHCRPGFEGEVCAEIAEHAATLEIPGYAKSKPASAHVEFVCQDADGAERLMRRLRFADLIFPRQWARGPGFIELPESQRIEVLLAELASYPVCGSLWLEVLDTNAGKEVSTFCRKFEKPLRAALVKAGRLQEDPALPRLLLTFRSGREVFVGLAEPRNSALWPMGIPRLKFPREAPSRSTLKLEEAWHQFIPRSEWDKRLAPDMLAVDLGAAPGGWTWQLVNREMRVTAVDNGPMAENLMYSGLVDHQKVDGYQYRPRQRVDWMVCDIVEKPARTGALIETWIGEGLCREAVVNLKLPMKQRYAEVRKILQRLRESFDARGLKVAIGCKQLYHDREEVTCHLRRLER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MX2_HUMAN
Sequence: MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLAKDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPLGTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH
What is the function of this protein?
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1).  Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA.  Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd).  May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
What are the official names of this protein?
Interferon-induced GTP-binding protein Mx2, Interferon-regulated resistance GTP-binding protein MxB, Myxovirus resistance protein 2, p78-related protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores requires GTP-binding.
Protein: SYP_AGRFC
Sequence: MRLSRYFLPILKENPKEAEIVSHRLMLRAGMIRQQSAGIYSWLPLGKRVLDKVNKIIREEQNRAGAIELLMPTLQTAELWQESGRYDDYGKEMLRIKDRQDRQMLYGPTNEEMITDIFRSYVKSYKNLPLNLYHIQLKFRDEVRPRFGTMRSREFLMKDAYSFDLTKEDAIHSYNKMFVAYLRTFERLGLRAIPMRADTGPIGGNHSHEFIILADTGESEVFCHKSFLDRAIPAESTDFDDVAALQGVFDEWTADYAATSEMHDDAAYDAIPEGERLSARGIEVGHIFYFGTKYSEPMGAKVQGKDGKEHPVHMGSYGIGPTRLVPAIIEASHDENGIIWPASVAPFDVVIINMKAGDAACDAACEKLYYQLSNAGKDVLYDDTDDRAGQKFATADLIGVPVQIIVGPRSVANGEVEVKDRKTGERETVTIEAAMNKALG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLRX4_BUCBP
Sequence: MNDIIKKIQNQIQNNPIIIYMKGSPDAPSCGFSAQAVHAISSCGKKFAYIDVLKNPDIRLELPKYANWPTFPQLWVNGELIGGCNIILELFQKGELKKTISICDKLNS
What is the function of this protein?
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.
What are the official names of this protein?
Glutaredoxin 4, Grx4, Monothiol glutaredoxin.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. Monothiol subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WSDU1_CHICK
Sequence: MATLIHTLTDHSDDVNCCAFSSSCLATCSLDKTIRIYSLNDFTELPYSPLKGHTYAVHCCCFSPSGHTLASCSTDGATIIWDTSDGRMLAVLEQPTGSPVRVCRFSPESTYLVSGAADGSVVLWNVHSMKFYRSGNVKDGSLVACAFSPGGNFFVTGSSCGDLTVWDDKMRCLCNEKAHDLGVTCCDISSHPVSDGEHASGCFQMASCGQDNKIKVWFILFADFLGGELRYKCTLSGHSAPVLTCAFSYDGQMLVSGSVDKCVIIYETNTGNILHTLSQHTRYVTTCAFAPCSLFLATGSMDKTVHIWKLDNKQPCAGNTIENDSKIRTAENWSEDDVSAWLCAQGFAELVGLFKANNIDGKELVNLTRESLIHELKMSLWLRSKILQKIEELRMKMVSVPVAVPDEFLCPITRELMKDPVIAADGYSYEKEAMENWISNNRRSSPMTNLPLPSLVLTPNRTLKMAISRWLETQQK
What are the official names of this protein?
WD repeat, SAM and U-box domain-containing protein 1.
Protein: GLYA_KOSOT
Sequence: MWELLAKGDPEVYEIVMKELGRQEEGLELIASENFVSPAVMEAMGSTLTNKYAEGYPRRRYYGGCKFVDEAEQLARERVKKLFNCKYANVQPHSGSQANMAAYLAVANPGDTIMGMSLSHGGHLTHGSPVNFSGKLFNIVSYGVDLETEVLDYDEIERLALEHKPKIIIAGGSAYSRIIDFKRFREIADKVGAYLIVDMAHFAGLVAAGLYPNPVDHAHIVTSTTHKTLRGPRGGLILTNDEELYKAINKAVFPGIQGGPLMHVIAAKAVAFGEALKDEFKEYQMRIITNAKALAKELENLGLRIVSGGTDTHLFLVDLNPKNVTGKAAEKALESADITVNKNTIPKETRSPFVTSGIRIGTPAVTTRGMGESEMKVIAELIVKVIDNIQDEKGTIPEEIREEVKKAVHELTEKFPLYKDLT
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCAR3_MOUSE
Sequence: MAAGKFASLPRNMPVNHQFPLASSMDLLSSKSPLAERRTDAYQDVSIHGTLPRKKKGPPSIRSCDNAGHSKSPRQSSPLTQDIIQENPLQDRKGENFIFRDPYLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREGSLAEGRPDVVKRLSLTTGSSIQAREHSLPRGNLLRNKEKSGSQPACLDHVQDRKALTLKAHQSESHLPIGCKLPPQSPSMDTSPCPSSPVFRTGSEPTLSPALVRRFSSDARTGEALRGSDSQLCPKPPPKPCKVPFLKTPPSPSPWLTSEANYCELNPAFAVGCDRGAKLPMQAHDSHEMLLTAKQNGPSGPRNSGINYMILDGDDQARHWDPLAVQTDEGQEDKTKFVPPLMETVSSFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSEDRKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNKIIQVAVELKDAMGDLYAFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPFSKILHEGRESTYVPASNVSVPLLMPLVTLMERQAVTFEGTDMWENNDESCEILLNHLATARFMAEASESYRMNAERILADFQPDEEMTEILRTEFQMRLLWGSKGAEVNQNERYDKFNQILTALSRKLEPPSGKQAEL
What is the function of this protein?
Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:12517963).  Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity).  Promotes insulin-mediated membrane ruffling (By similarity).  In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:10896938).  Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (PubMed:25499443).  May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (PubMed:25499443).  Regulates EGF-induced DNA synthesis (By similarity).  Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (PubMed:19365570).  Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (PubMed:22801373).  Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (PubMed:22801373).  Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (PubMed:10896938).  However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity).
What are the official names of this protein?
Breast cancer anti-estrogen resistance protein 3 homolog, p130Cas-binding protein AND-34.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Note=Localization to focal adhesions depends on interaction with PTPRA.
Protein: QUEC_PSEMY
Sequence: MSDKKAVILLSGGLDSATVVAMARAEGYACYSMSFDYGQRHRAELQAAERVARQLGVVEHKVVGLNLNGIGGSALTDSSIAVPETPGEGIPVTYVPARNTVFLSLALGWAEVLGARDIFIGVNAVDYSGYPDCRPEFVEAFERMANLATKAGVEGQGFAIRAPLQQMSKGEIIQAGMRLGVDYALTVSCYQADDDGRACGKCDSCRLRAAGFAAAGVPDATRYF
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: KJ45_SCHPO
Sequence: MPSDKPVFDIGSQAPERSDSESPSSRSIGSGTPAPVRKGLSKFKNSFLSRKNSSQIKSPSDYKSSAHEQRVNHTTDSMAHVPGNNSPLQTPQKSPPRQKHTAPATPIPVSASRHHKPHHSGLKNLLEKAMHPGHKSNANSPTSESPSKGFGSFINNHILHKNTSSHPSSPVNGKSSDIHKSQSYQHLKNSPPNSRTARKPVPRRANSASHNLGSTKSPNGNAKESLSRSAELPSKAKPMEINNGYRKKPSPLSPNSSIRNREGGNGSYFDGPLTASPTPSSPTGTPNSMSKSPSLSSLASTGASYRPGPSKPLVSRVRDNYANTSYESWPHSTEFDMFTYAVSGSLKLTPQGTGFDCINPANPFSPGYSGKSSMKSDDNVGSSANTAPNSPTSANSSEGNQGNGPTTYPIKPPTNISEIPRKLKSGFIPPYAKRVVPRLSAKYKLVDETKDMGSGATAVIRIVTLKNPKENEKNLRFAVKAYRRKADDETDGQYIAKLASEWLVQCRMEHPNVVKSYDLCIDSHIFPLYSDTWCAVMDFCPRGDLLSLIEDRHDRLGKKDFECMIKQILRGLNYIHSQGIAHRDIKPENILISEYGVLRITDFGACDVLCNPGDDITAVESKSMGIFGSDPYMAPEILTPGSYNAFFADMWSTAIVLHCLYFRTYPFRKASQNDQLYAKYCKAWREYNLICDVQNIRISKTLPYFKPVNDLPMHMQRLFFCLANPTAEQRITAQEALNLPFVQEIECCSVDDCTCTHDAPEECLEWANPPVQKLSTPHNHL
What are the official names of this protein?
Probable serine/threonine-protein kinase C70.05c.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEF1_HUMAN
Sequence: MASSVDEEALHQLYLWVDNIPLSRPKRNLSRDFSDGVLVAEVIKFYFPKMVEMHNYVPANSLQQKLSNWGHLNRKVLKRLNFSVPDDVMRKIAQCAPGVVELVLIPLRQRLEERQRRRKQGAGSLQELAPQDGSGYMDVGVSQKARGEGVPDPQGGGQLSWDRPPAPRPPAYNRALQGDPSFVLQIAEKEQELLASQETVQVLQMKVRRLEHLLQLKNVRIEDLSRRLQQAERKQR
What is the function of this protein?
Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation.  Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity).  Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity).  Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity).  Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (PubMed:31473225).  Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity).
What are the official names of this protein?
Sperm flagellar protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Apical cell membrane. Basolateral cell membrane. Cytoplasm, cytoskeleton, stress fiber. Cell projection, microvillus. Cell projection, lamellipodium. Cell projection, filopodium. Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225).
Protein: MDTH_SALSV
Sequence: MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAILFILCALFNAWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAGSPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMIPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDMGKALAQPELPWMMLGIIGFITFLALGWQFSHKRTPRRMLEPGA
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LAC_AGAPC
Sequence: DVIGPQAQVTLANQD
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products (By similarity).  Active against a variety of substrates including the benzenediols hydroquinone and catechol, the benzenetriol pyrogallol, the methoxy-substituted phenol 2-methylcatechol, the aromatic diamine N,N-dimethyl-1,4-phenylenediamine and the nonphenolic heterocyclic compound ABTS (PubMed:23093860).  Shows highest degradative activity towards hydroquinone with lower activity against ABTS and N,N-dimethyl-1,4-phenylenediamine (PubMed:23093860).  Activity towards pyrogallol, catechol and 2-methyl-catechol is considerably attenuated (PubMed:23093860).  Shows no activity against tyrosine (PubMed:23093860).
What are the official names of this protein?
Laccase.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: SELB_METJA
Sequence: MVISMEMKNVNVGLFGHIDHGKTQLAKQLTEIASTSALDKPKESQKRGITIDLGFSSFTLDRYRITLVDAPGHSELIRTAIGAGNIIDAALLVVDAKEGPKTQTGEHLLVLDLLNIPTIVVINKIDIANDEEIKRTEMFMKQILNSTINLKNSKIIKISAKTGEGIGELKKELKNLLDSLDIKRDINSYLKMPIDHAFKIKGVGTVVTGTIHKGKVEVGDNLRILPINHEVKVKSIQCFKQDVSIAYAGDRVGMALMGVEPESLFRGCILTSEDTKLKVVDKFIAKVKILELFKYNLAPKMKVHINIGLLTVPATIIPYKIEKINDKEEPIILEEIKGGDSCYCIFKLEERVVVDEGDKILIMRLDLPPTTLRICGFGEVIDFGEVEVKKIVVKEGKVVKKKDKIYIEGLASSKTAGEKLIGGKVYIPDKNIWGVIKGTFGTKGALIAEFDEEVNGGEKVVLKRVRKWG
What is the function of this protein?
Translation factor necessary for the incorporation of selenocysteine into proteins.  It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon.  SelB binds GTP and GDP.
What are the official names of this protein?
Selenocysteine-specific elongation factor, SelB translation factor.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHAR4_PONAB
Sequence: MEDPFEEADQPATEPGMVMDSVEAGDTTPPTKRKSKFSGVGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSHAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLAKTVNLSVTPSPAPRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIQFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPVTPTLEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQICPSTFSEETTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP
What is the function of this protein?
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development.  Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'.  During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina.  Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
What are the official names of this protein?
Phosphatase and actin regulator 4.
What is the protein family that this protein belongs to?
Belongs to the phosphatase and actin regulator family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, lamellipodium.
Protein: AMPP2_METRA
Sequence: MEMDYDLVMEDEFDALCLDVRRHHDSTSKTKYPAKLHARKVVRELGVDDGLIYLPGQPEISLEDSDQPRLFRQRRYFFYITGANFEDCTATYEVKHDKLTLWIPYVEPRQVLWFGSKPSAAECKRRYDVDEVRYTTQLSGFLRSFAAQPSPPVTYILHPKQAPDLGHGSQSQLCLDSSLLLPAMDRARVVKSDYEVAMVRRANNISSAAHRRVAERILRLTNEREIEAIIQAVCIASGSRSQAYPIIAGSGANGATLHYGSNNASLGGKQCVVIDAGCEWNCYASDITRTLPLSGAWTPKAAAIHAIVQRMQDECIAKVGPGAAWREIHLHAASVGMEGLLGLGILKGRREDVARAGTVAAFFPHGLGHHVGLDVHDVSGTLALSAAEGRGQQLDFGKRAMVTPSMLADMTRVSSSQDAVGGGQSKTQLLLPNMIVTVEPGIYFCREYLEGYFRSDPAHADFIDWDLLEEYYDVGGVRIEDCILVTEDGYENLTVAPKGDELLDVINKGKK
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase MAA_08947, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: THN_BRARP
Sequence: MEGKTVILGVIIMSLVMAQNQVEAKICCPRTIDRNIYNACRLTGASMTNCANLSGCKIVSGTTCPPGYTHDILQNYGDAVNEYCKLGCASSVCGALTTLKNSMQVNCEGAVSQCTNACSNFCTKGSAKVVETA
What is the function of this protein?
Thionins are small plant proteins which are toxic to animal cells.  They seem to exert their toxic effect at the level of the cell membrane.  Their precise function is not known.
What are the official names of this protein?
Thionin.
What is the protein family that this protein belongs to?
Belongs to the plant thionin (TC 1.C.44.1) family.
Protein: HTR10_MAGO7
Sequence: MQIFNMVSLVALFALGATAVPVSSITGVQCCQANHGDLTTPQAQSLFKSHQKRQDYWVCHACNKQFTTPAALQKHKDTVVHP
What is the function of this protein?
Probable secreted effector that translocates into the nuclei of host cells to reprogram the expression of targeted genes by binding on effector binding elements in rice.
What are the official names of this protein?
Host transcription reprogramming factor 10, Secreted nuclear effector HTR10.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: SYC_LACPL
Sequence: MLSVFNTLTRQKEPFKPITPGVVKMYVCGPTVYNYIHIGNARSAIAFDTIRRYFEYCGYHVDYVSNFTDVDDKLIKRAAEDHTTVPAVADRFIKAFMEDTTAVNIEPATVHPRASENIPEIIAFVQALIEKGYAYESAGDVYYRARKFKKYGQLSDQRIDDLEVGASQHTADEETDRKEDPIDFALWKAAKPGEISWESPWGAGRPGWHIECSVMSTKYLGDTFDIHGGGQDLEFPHHENEIAQSEAKTGKTFANYWLHNGFVTVGDDNEKMSKSLGNFVTVHDIIKTVDPQVLRFFMATTQYRRPIQYTQANLDEAANNLDKLRNAYRNLTFRLQDATNGTDTAVAEQLQTLITNFGTAMDDDFNVQNGVAAVYELAKLANVYAAKATVQKETLIALQKALVQLTGVFGVTFETANATLADDAIQALIDEREAARKAKDFAKADQIRDDLKVQGIMLEDTPQGVRFRKE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.