PharMolix/UniProtQA huggingface dataset:
Protein: MINC_VIBC3
Sequence: MSKNPDLKGSSFTLSVLHLSDNQIAHTVQFLQEKIAQAPAFFANAPVVINVAKVEGDIDYPALKQGISQAGLIPVGVTGCKDKRSQNLAVEAGFAVMTATNSPAQAPAQMAPTKVIRTPVRSGQQIYAKDGDLVILSHVSAGAEVIADGSIHIYGTLRGRAIAGASGQREARIICHDLQAELISIAGRYWLSDQIESQFWQQRVMLSMTDESLYLETLTI
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: TRMD_ECO45
Sequence: MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNBI_VZVO
Sequence: MENTQKTVTVPTGPLGYVYACRVEDLDLEEISFLAARSTDSDLALLPLMRNLTVEKTFTSSLAVVSGARTTGLAGAGITLKLTTSHFYPSVFVFHGGKHVLPSSAAPNLTRACNAARERFGFSRCQGPPVDGAVETTGAEICTRLGLEPENTILYLVVTALFKEAVFMCNVFLHYGGLDIVHINHGDVIRIPLFPVQLFMPDVNRLVPDPFNTHHRSIGEGFVYPTPFYNTGLCHLIHDCVIAPMAVALRVRNVTAVARGAAHLAFDENHEGAVLPPDITYTYFQSSSSGTTTARGARRNDVNSTSKPSPSGGFERRLASIMAADTALHAEVIFNTGIYEETPTDIKEWPMFIGMEGTLPRLNALGSYTARVAGVIGAMVFSPNSALYLTEVEDSGMTEAKDGGPGPSFNRFYQFAGPHLAANPQTDRDGHVLSSQSTGSSNTEFSVDYLALICGFGAPLLARLLFYLERCDAGAFTGGHGDALKYVTGTFDSEIPCSLCEKHTRPVCAHTTVHRLRQRMPRFGQATRQPIGVFGTMNSQYSDCDPLGNYAPYLILRKPGDQTEAAKATMQDTYRATLERLFIDLEQERLLDRGAPCSSEGLSSVIVDHPTFRRILDTLRARIEQTTTQFMKVLVETRDYKIREGLSEATHSMALTFDPYSGAFCPITNFLVKRTHLAVVQDLALSQCHCVFYGQQVEGRNFRNQFQPVLRRRFVDLFNGGFISTRSITVTLSEGPVSAPNPTLGQDAPAGRTFDGDLARVSVEVIRDIRVKNRVVFSGNCTNLSEAARARLVGLASAYQRQEKRVDMLHGALGFLLKQFHGLLFPRGMPPNSKSPNPQWFWTLLQRNQMPADKLTHEEITTIAAVKRFTEEYAALNFINLPPTCIGELAQFYMANLILKYCDHSQYLINTLTSIITGARRPRDPSSVLHWIRKDVTSAADIETQAKALLEKTENLPELWTTAFTSTHLVRAAMNQRPMVVLGISISKYHGAAGNNRVFQAGNWSGLNGGKNVCPLFTFDRTRRFIITCPRGGFICPVTGPSSGNRETTLSDQVRGIIVSGGAMVQLAIYATVVRAVGARAQHMAFDDWLSLTDDEFLARDLEELHDQIIQTLETPWTVEGALEAVKILDEKTTAGDGETPTNLAFNFDSCEPSHDTTSNVLNISGSTVPGLKRPPEDDELFDLSGIPIKHGNITMEMI
What is the function of this protein?
Plays several crucial roles in viral infection.  Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.  Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle.  Can also catalyze the renaturation of complementary single strands.  Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments.  This process is driven by the protein which can form double-helical filaments in the absence of DNA.
What are the official names of this protein?
Major DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae major DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=In the absence of DNA replication, found in the nuclear framework- associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).
Protein: 14333_ENTH1
Sequence: MAESREDCVFLSKLAEQSERYDEMVQYMKQVAALNTELSVEERNLLSVAYKNVIGSRRASWRIITSLEQKEQAKGNDKHVEIIKGYRAKIEDELAKYCDDVLKVIKENLLPNASTSESKVFYKKMEGDYYRYYAEFTVDEKRQEVADKSLAAYTEATEISNADLAPTHPIRLGLALNFSVFYYEIMNDADKACQLAKQAFDDSIAKLDEVPESSYKDSTLIMQLLRDNLTLWTSDTADEE
What is the function of this protein?
Adapter protein which is required for phagocytosis and motility, probably by regulating actin cytoskeleton dynamics (PubMed:31095644).  During phagocytosis, plays a role in the initiation and/or formation of the phagocytic cup and is involved in the recruitment of the actin binding protein coactosin to the phagocytic cup (PubMed:31095644).
What are the official names of this protein?
14-3-3 protein 3, 14-3-3-3, EhP3.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: CTR9_XENLA
Sequence: MSRGSIEIPLRDTDEVIELDFDQLPEGDEVISILKQEHTQLHIWIALALEYFKQGKTEDFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKNKDNKKELITQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAGVRLGMGHCFVKLNKLDKARLAFGRALDLNPTCVGALVGLAVLELNNKEADSIKNGVQLLSKAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFAAASFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASDDQEKRDIAKSHLKKVTEQYPDDVEAWIELAQILEQTDIQNALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNSISVTTSYNLARLYEGLCEFHESEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQNDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDSKNLFAANGIGAVLAHKGYVREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVLLYLARALFKCGKLQECKQILLKARHVAPNDTVLMFNVALVLQRLATLVLKDEKSNLKAVLNAVKELELAHRYFNYLSKVGDKMRFDLALATSEARQCSDLLSQAQYHVARARKQDEEEKEMRTKQEQEKEVLRQKLLKEQEEKHLREIEEQKKLLEQRAQYLEKTRNLLSFTGEMETPKEKKQRGGGGRRSKKNGEFEEFVNDDSDEELAPRKKKRKKGGSSSGEQGEGGDEGEGGEKKKKKRRKRPQKAAGSDDDEEQTPQSKKRQPKKKEKPAKLERTPPSMKGKIKSKAIISSSEDDSDEDKLKIADEGHARDSDSDDGPRKSQKRVISDSDSDNGNKSGSDAGSPQKSQRSDEDSDNAFARKRRRQISGSDNDSAQSRRSSGGSDNESRAASNSAESERGSDRGSDNEGSERASGNQSEQEVEKSERGSDESD
What is the function of this protein?
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II (By similarity).  PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).
What are the official names of this protein?
RNA polymerase-associated protein CTR9 homolog, SH2 domain-binding protein 1.
What are the subcellular locations of this protein?
Nucleus speckle.
Protein: THIG_PSEP1
Sequence: MSNVRSDKPFTLAGRTFQSRLLVGTGKYRDMEETRLATEASGAEIVTVAVRRTNLGQNAGEPNLLDVLSPDKYTILPNTAGCFDAVEAVRTCRLARELLDGRKSHESRTLVKLEVLADQKTLFPNVIETLKAAEVLVKEGFDVMVYTSDDPIIARQLAEVGCIAVMPLAGLIGTGLGICNPYNLQIILEESKVPVLVDAGVGTASDATIAMEMGCEAVLMNSAIAHAQQPVLMAEAMKHAIVAGRMAYLAGRMPKKLYASASSPLDGLIK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_ECO55
Sequence: MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDELRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIFK_MOUSE
Sequence: MRSLPFFCRGQVVRGFGRGSKQLGIPTANFPEQVVDNLPADVSTGIYYGWASVGSGDVHKMVVSIGWNPYYKNVKKSMETHIIHTFKEDFYGEILNVAIVGYLRPEKNFDSLESLISAIQGDIEEAKKQLDLPEHLKLKDDNFFQVSKGKIMNGH
What is the function of this protein?
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD.  Essential for TNF-induced reactive oxygen species (ROS) production.  Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase.  TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase (By similarity).
What are the official names of this protein?
Riboflavin kinase, ATP:riboflavin 5'-phosphotransferase, Flavokinase, KOI-4.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QKI_CHICK
Sequence: MVGEMEAKEKPKPSPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLIPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN
What is the function of this protein?
RNA-binding protein that plays a central role in myelinization.  Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence.  Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation.  Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation.  Participates in mRNA transport by regulating the nuclear export of MBP mRNA.  Also involved in regulation of mRNA splicing of some pre-mRNA.  Acts as a translational repressor (By similarity).
What are the official names of this protein?
KH domain-containing RNA-binding protein QKI, Protein quaking.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ATPD_CAMJR
Sequence: MENIIARRYAKAIASRADINDFYQNLCILNSAFVLPKFKNIIESNEIKKERKMEFLDSFFDIKNSSFQNFLRLLIENSRLECIPQIVKELERQKAFKENIFVGIVYSKEKLSQENLKDLEVKLNKKFDANIKLNNKISQDDSVKIELEELGYELSFSMKALQNKLNEYILKII
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYE_BACCR
Sequence: MEKQVRVRYAPSPTGHLHIGNARTALFNYLFARHLDGKFIIRIEDTDVKRNVAGGEESQLKYLKWLGMDWDEGVDVGGEFGPYRQTERLDIYKKLYEDLLERGLAYKCYMTEEELEAEREGQIARGETPRYACNHRELTEEQVKEFEAEGRIPSIRFRVPANRDYTFKDIVKDEVAFHSNDFGDFVIVKKDGIPTYNFAVAVDDHLMEITHVLRGDDHISNTPKQMMIYEAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEAIFNFIALLGWSPVGEEEIFSKDEFIKMFDAARLSKSPALFDSQKLKWMNNQYMKKQDLDTVVELSLPHLVKAGRVGETLSEQDQAWIRDVIALYHEQMSFGAEIVELSEMFFKDHVDYEEEGQEVLNGEQVPEVLRAFAGQIEALEVMEPAAIKAAIKAVQKETGHKGKNLFMPIRVATTGQTHGPELPNAIALLGKEKVLNRLQKVIG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXJ_HELHP
Sequence: MSIRLGVNIDHIATLREARAIYEPDPLEAVFIAKNAGAHQITFHLREDRRHIHDSDVKRIIQSSPLPINIECALDEKIIDYLCGLKPQRITLVPEKREEITTEGGLDIESRYDSIRDTLKAFESCGIVSALFIDPKKESIFLARELGAQAVELHTGRYANLMLMAYSNLSRTHRALEEFAFPTQEINEEISRTLDDIAQCAKLATSTIDTRPLECFAGHGLNYQNVGAIAQIPQISELNIGHSIIARSVFVGLERAIIQMREAMCQK
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCP_THEM4
Sequence: MFCYQCSEASKGVGCTTIGVCGKTPDVANLQDLLIWLTRGISYWALKAKEYGVKDDEVNLFVAEALFSTITNVNFSAKRMVEFIERAFELRERIKHRFLEAYAEKEGKTFDEKVPEAAEWHKKGGVDLYELKGMEVGVLFDKDEDIRSLKQLLIYGLKGIAAYTDHAYILKHTNDDILYFIQKGLVETLREDITVDELVSLVLEAGKVAVDAMALLDKANTTEFGNPEITEVYTGTYNTPAILVSGHDLLDLEELLKQTEGTGIMVYTHGEMLPAHAYPKLKKYKHLAGNFGSAWWKQSEEFEEFGGAILMTTNCLVPPKESYKDRVFTTGLVGFDKLTHIPNRTDGKPKDFSPVIKKALELGPIPERKGKKIVIGFAHDQVSRLLDKVIDAVKSGAIKKFVVMGGCDGRHKEREYYTEFAKKLPKDTVILTAGCAKYRYNHLDLGDIGGIPRVLDAGQCNDSYSLVVTALKLKEALGLDDINDLPIVYNIAWYEQKAIAVLLALLYLGVKGIRLGPVLPAFISPNVLKVLVDKFNIAPITTVEEDLKVLLS
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TU61_GEMSP
Sequence: MRLQLILTITLLLTSFMGYRDAAVIQGKTERSAMKMRKLLQILHKNSCGCNDDDSDGDDCCFGTCLDNACWPVKKRSSAI
What are the official names of this protein?
Turripeptide VI/VII-01.
What are the subcellular locations of this protein?
Secreted.
Protein: NRDR_DEIRA
Sequence: MKCPYCSSPDSRVINSRPSDDGASIRRRRECLTCTRRFTTYERAQLEPLMVVKRSGVREAFNPDKLLRGLALASEKRPVEEAALRTFAYSFEDEVQGGEIPTEEIGRRAMTFLRPLDDVAYIRFASVYRDFDSLERFIEEIRGLKGHEDEAPKSDPA
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: ERA_STAAB
Sequence: MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFIDTPGIHKPKHKLGDYMMKVAKNTLSEIDAIMFMVNANEEIGRGDEYIIEMLKNVKTPVFLVLNKIDLVHPDELMPKIEEYQSYMDFTEIVPISALDGLNVDHFIDVLKTYLPEGPKYYPDDQISDHPEQFVVGEIIREKILHLTSEEIPHAIGVNVDRMVKESEDRVHIEATIYVERDSQKGIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: LCDH_BURMA
Sequence: MAVITKIDTFAAIGAGVIGSGWVARALANGLDVLAWDPAEDAEMQLRANVENAWPALERAGLAPGASPARLHFVPTIEACVADADFVQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARAHRPERCIVGHPFNPVYLLPLVEVLGGERTAPDTVDAALGIYRALGMRPLRVRKEVPGFIADRLLEALWREALHLVDEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLAGGEAGMRHFMQQFGPALELPWTKLVAPKLTDALIDRVVEGTAEQQGPRSIKALERYRDECITEVIAAIAAVKARHGMRYED
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.
What are the official names of this protein?
L-carnitine dehydrogenase, CDH, L-CDH.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_BURTA
Sequence: MLQPKRRKYRKEQKGRNTGIATRGNAVSFGEFGLKAVGRGRLTARQIEAARRAMTRHIKRGGRIWIRIFPDKPISQKPAEVRMGNGKGNPEYYVAEIQPGKMLYEMDGVSEELAREAFRLAAAKLPLKTTFIVRQLGA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ILVC_AROAE
Sequence: MKVYYDKDADLSLIKGKQITIVGYGSQGHAHAQNLKDSGCKVTVGLRKSGASWKKAEAAGLDVREVAEAVSNADIVMILLPDENIPGVYYNDVEPNIKQGATLAFAHGFNVHYNQVVPRDDLDVIMVAPKGPGHTVRSEYLKGGGVPSLIAVHQDRSGKAKDIALSYAAANGGTKGGVIETNFREETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGPEVINEQSREAMRAALKRIQTGEYAKMFIQEGRTNYPSMTARRRLNAAHPIEQVGGQLRDMMPWIKKNKLVDQSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: CRCB1_STAAN
Sequence: MHRQFLSSCCQNLFFKFKLLLFEVNQMQYVYIFIGGALGALLRYLISFLNTDGGFPIGTLIANLTGAFVMGLLTALTIAFFSNHPTLKKAITTGFLGALTTFSTFQLELIHMFDHQQFITLLLYAVTSYVFGILLCYVGIKLGGGLS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAPB_STRPS
Sequence: MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQGIPVFKDKADLAGFEADVWIDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELKEFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKTAELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGLTLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_CROS8
Sequence: MSGTLLAFDFGTKSIGVAIGQRVTATARPLTAIKAQNGNPDWTLIEKLLKEWQPDDVIVGLPLNMDGTEQPLTARARTFANRLHGRFGIKVTLHDERLSTVEARAGLFERGGFRALNKGSVDSASAVVILESYFEQHG
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROCK2_HUMAN
Sequence: MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS
What is the function of this protein?
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.  Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM.  Phosphorylates SORL1 and IRF4.  Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation.  Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation.  Plays an important role in the timely initiation of centrosome duplication.  Inhibits keratinocyte terminal differentiation.  May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles.  Plays a critical role in the regulation of spine and synaptic properties in the hippocampus.  Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
What are the official names of this protein?
Rho-associated protein kinase 2, Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, ROCK-II, p164 ROCK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane.
Protein: VNN1_CANLF
Sequence: MITSRLLVYVAVLVLCVIKVSSRDTFIAAVYEHAVKLPNATLVPVSHEEALAVMNQNLDLLEAAITSAANQGAHIIVTPEDGIYGWNFSRETIYPYLEDIPDPGVNWIPCNNPKRFGYTPVQERLSCLAKDNSIYVVANIGDKKPCNASDSQCPLDGRYQYNTDVVFDSQGKLVARYHKHNLFMGENQFNVPKKPEIVTFDTIFGRFGVFTCFDILFYDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAIQFHSAWAMGMGVNFLASNIHHPSKRMTGSGIYAPDSPRAFHYDMKTKEGKLLLSQLDSYTHHPIVVNWTSYASGIKAFPTENQEFTGTAFFDEFTFLELTRVTGNYTVCQKKLCCHLSYKMSEKRTDEVYALGAFDGLHVVEGRYYLQICTLLKCKTAHVHTCGGAVETASTRFDMFSLSGTFGTQYVFPEVLLSETQLAPGEFQVSSDGRLFSMKPLSGPLLTVTLFGRIYEKDQTLKASSDPRSQVPGVMLLVIIPIVCSLSW
What is the function of this protein?
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
What are the official names of this protein?
Pantetheinase, Pantetheine hydrolase, Tiff66, Vascular non-inflammatory molecule 1, Vanin-1.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.