PharMolix/UniProtQA huggingface dataset:
Protein: UNG_BORGP
Sequence: MKVKIEESWKEVLNNEFNKGYFKKLVKFIKHEYKTKKGKIFPPPKLIFNAFDSLPFKDIKVVIIGQDPYHGKNQANGLAFSVDSEIKIPPSLQNIFKEIEKSLKIKTLPNGDLKRWAIQGVFLINTILTVEEGKPSSHKDIGWEIFTDEVIKIISKNLENIVFMLWGNLARSKKKLINPTKHLILETSHPSPYSANNGFLGSNHFSDALNYLKQHNKNKINFQ
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_ECO5E
Sequence: MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNM5_LISMO
Sequence: MSGKPVIHEFIVVEGRDDTTAINRSVIADTIETNGSALSQETIEKIRHAQELRGVIIFTDPDFPGEKIRKQIDSAVPGCKHAFINRQDALPKAGRGLGVEHASSANIREALENFHTSGAPTEKQFISKDILVHLGLLGGVGAKERREKIGNILKIGYTNGKQLQTRLESFAISEEQLVAACQKIMQEEENE
What is the function of this protein?
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor.  Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.
What are the official names of this protein?
Ribonuclease M5, RNase M5, Ribosomal RNA terminal maturase M5.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease M5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKN1_RAT
Sequence: MAGDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLKREIRKELKLKEGAENLRRATTDLGRSLAPVELLLRGSARRLDLLHQQLQELHAHVVLPDPTAGSDAPQSLAEGSPVCSSTNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQALQAGQLESQAAPDEAHGDPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLRESLERRLGELPADHPKGRLLREELTAASSAAFSAILPGPFPATHYSTLSKPAPLTGTLEVRVVGCKNLPETIPWSPPPSVGASGTPDSRTPFLSRPARGLYNRSGSLSGRSSLKGEAENSTEVSTVLKLDNTVVGQTAWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPIIERIPRLQRQKKIFSKQQGQTFQRARQMNIDVATWVRLLRRLIPNAVATGSFSPNASPGSEIRSTGDISMEKLNLGADSDSSSQKSPAGLPSTSCSLSSPTHESTTSPELPSETQETPGPGLCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFHSSGELFAIKALKKGDIVARDEVESLMCEKRILATVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAVFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRTLDWDALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFRDFDFVAGGY
What is the function of this protein?
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation (PubMed:8051089, PubMed:15375078).  Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14 (By similarity).  Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization.  Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly.  Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C.  Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus.  Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP.  Able to phosphorylate RPS6 in vitro (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase N1, Protease-activated kinase 1, PAK-1, Protein kinase C-like 1, Protein kinase C-like PKN, Protein-kinase C-related kinase 1, Serine-threonine protein kinase N.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner (By similarity). Localization to endosomes is mediated via its interaction with RHOB. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis (By similarity). Association to the cell membrane is dependent on Ser-377 phosphorylation.
Protein: TRPC_LACPL
Sequence: MILDQLVQASQQRVQKVPVRERVKRIQQARKMTTPVLSFEAMLAQPGLQLIGEVKRASPSKGLIAAEFDYLQIAQDYVAAGIDAISVLTEPRYFKGQLSYLQAITQTVSVPTLRKDFIVAASQIASARIAGASAVLLIVAILTPVQLQAFITLAHELNLSALVEVHTTAESKQAVAAGARIIGINNRNLKDFSVNFATSCQLRQAVPAECYVVAESGIQTATQAQQLAAAGFDAMLVGETLMRAPDKGQAVMQLRAGVRG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: BR11_SYLSP
Sequence: MFTMKKPLLLLFFLGTINLSLCEEERNADEEEKRDGDDEMDAEVEKRFLPAVLKVAAHILPTAICAISRRC
What is the function of this protein?
Antimicrobial peptide.  Active against some Gram-negative and a variety of Gram-positive bacterial strains.  Active against fungus C. glabrata 090902 but not against C. albicans ATCC 10231.  Shows hemolytic activity against human erythrocytes.
What are the official names of this protein?
Brevinin-1SN1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: LIPA_BRUSU
Sequence: MVTVLNTVNQSGRLRHPEKAHRPDNEVLKKPDWIRVKAPVSRGYGETREIVRSNKLVTVCEEAGCPNIGECWEKKHATFMIMGEICTRACAFCNISTGIPNALDPNEPENIAKAVKQMGLTHVVITSVDRDDLADGGAHHFAEVIKAVREAAPATTIEILTPDFLRKEGALEIVVKARPDVFNHNLETVPSKYLKVRPGARYFHSIRLLQRVKELDPTIFTKSGIMVGLGEERNEILQLMDDLRSADVDFMTIGQYLQPTRKHHPVIRFVKPDEFKSFETIGKTKGFLLVASSPLTRSSHHAGEDFAKLKAAREALYASRAS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCP_BOVIN
Sequence: MRASCTPLKAPLRRPERLASSGRFAWVLLLAPLLLLPTSSDACDDPPRFVSMKPQGTLKPSYSPGEQIVYECHLGFQPVTPGQVLALVCQDNNTWSSLQEGCKKRRCPTLADPTNGQVILVNGSTEFGSEVHYVCNNGYYLLGTNISYCEVSSGTGVNWSDNPPTCEKILCQPPPEIQNGKYTNSHKDVFEYNEVVTYSCDPSNGPDEYSLVGESKLTCIGNGEWSSQPPQCKVVKCVYPAIEHGTIVSGFGPKYYYKATVVLKCNEGFNLYGNSVVVCGENSTWEPELPKCIKGHPPRPTDASPPNGAEGLGAGYIVLVIVAVLIGVGLLLCLYCCFCRQRKKGIYVTGESHRQDILFSL
What is the function of this protein?
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue.  May be involved in the fusion of the spermatozoa with the oocyte during fertilization.  May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.  T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity).  In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells.
What are the official names of this protein?
Membrane cofactor protein.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa.
Protein: MNMA_CHLMU
Sequence: MRKTVIVAMSGGVDSSVVAYLLKKQGKYDVIGLFMKNWEEQDENGECTATKDFLDVEQIAEQLSIPYYTVSFAKEYKERVFSRFLKEYTNGYTPNPDVLCNREIKFDLLQKKVRELKGDFLATGHYCRGGLDGTGLFRGVDPNKDQSYFLCGTPKEALSNVLFPLGGMYKTEVRQLAIEAGLATATKKDSTGICFIGKRPFKSFLEQFVPNSPGDIVDFDTQKVVGCHEGAHYYTIGQRRGLNVGGMEKPCYVLGKDMQKNVVYIVRGEDHPLLYRKELIAKELNWFVPLQGSITCSAKVRYRSPDEKCSVYPLEDGTVQVVFDIPVKAVTPGQTVAFYQGDVCLGGGVIAVPMIHQL
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK20_COFAR
Sequence: MTRIRRGYIARRRRTKIRLFASSFRGAHSRLTRTITQQKIKALVSAHRDRDSKKRNFRRLWIIRINAIIRERVVEWALSYSYSRLIHDLYKRQLLLNRKILAQIAISNRNCLYMISNELYKYKEVEESSGII
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PANB_BRUME
Sequence: MSAPVTRKRLTPKVIQAMKGECPIVSLTAYTTPVARLLDPHCDLLLVGDSLGMVLYGMESTLAVTLDMMIMHGQAVMRGTSHACVIVDMPFGSYQESKEQAFRNAARVMQETGCDGVKLEGGEEMAETVAFLVRRGIPVFGHVGLMPQQVNTVGGFRSLGRGDDEAGKIRRDAQAIAQAGAFAVVIEGTVEPLAREITALIDIPTVGIGASSACDGQVLVSDDMLGLFQDFTPRFVKRFAHLAPQVSQAAEAYAEEVRARRFPGPEHVFGAKPGA
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR8_SELUN
Sequence: MGNDAIDDVTTAPRNASSRGAETVRVSSTDITISIGRVLVEEGFSGNPREHRQGTNRFPVSTSKYQGRTRKARITTRRRVSKPGLRIYPGYKDIPEVSGGIGTATPPTPGGTTTDREARQKRIGGEAPRHVWR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SRC8_CHICK
Sequence: MTVLLLVVLQMWKATAGHSIAVSQDDGADDWETDPDFVNDVSEKEQRWGAKTVKGSGHQEHINIHQLRENVFQEHQTIKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVKGFGGKFGVQTDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGVDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKVQLHESQKDYKSGFGGKFGVQTERQDPSAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMDKNAATFEDIEKPTSTYQKTKPVERVANKTSSIRANLENLAKEKEQEDRRKAEAERAQRMAREKQEQEEARRKLEEQAKAKKQTPPPSPTTQPAEPKTPSSPVYQDAVSYDAESAYKNSSTTYSAEHEPESGYKTTGSDYQEAVSQREAEYEPETVYEVAGAGDHYQAEENTYDEYENELGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
What is the function of this protein?
Contributes to the organization of the actin cytoskeleton and cell shape (By similarity).  Plays a role in the formation of lamellipodia and in cell migration (By similarity).  Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones, and may play a role in the regulation of neuronal spine density (By similarity).  Plays a role in focal adhesion assembly and turnover (By similarity).  Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (By similarity).  Plays a role in endocytosis via clathrin-coated pits (By similarity).
What are the official names of this protein?
Src substrate protein p85, Cortactin, p80.
What are the subcellular locations of this protein?
Cell membrane. Endoplasmic reticulum. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendritic spine. Cell projection, dendrite. Cell projection. Cell junction. Membrane, clathrin-coated pit. Cell junction, focal adhesion. Cell projection, podosome. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In normal cells, probably in association with the plasma membrane and possibly the endoplasmic reticulum (PubMed:1922035). p80/85 colocalizes with F-actin in peripheral extensions of normal cells and rosettes (podosomes) of src-transformed cells. p80/85 probably associates with components of the cytoskeleton. In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity).
Protein: YZ20_AQUAE
Sequence: MRLSEYKRSNSAQNFDEFFRKGYVSILYGDSGVGKTTISLYLCLLAGAGKNLFHNLLKVKEPKKVAYISLELYKEDILEKLEPIRKRYRISTSEMEIMDLDDISDYRSFEKILEQKRYDFVVVDSFVAFYEGKSIYDPVEVKEFIKKTRKLARNSESHIMFIHHTIKSSGKNKTDRYQGVSTIKFLTTPFMQAYTEGKSFRVLTIEKHNFAYPFEKIYYYINKNGAITWYINEKAKYEEILHKFEPILKHLKDREYGMKTDELLNLSGLKKRTFYAHLNKLEEMGIIEWHHKGSKVSRVSISKRFKFILKRNNKFKRE
What are the official names of this protein?
Uncharacterized protein aq_aa20.
Protein: CAIT_ECOSM
Sequence: MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLMDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD
What is the function of this protein?
Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
What are the official names of this protein?
L-carnitine/gamma-butyrobetaine antiporter.
What is the protein family that this protein belongs to?
Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS12_HAES1
Sequence: MATINQLVRKPRVKKVVKSNVPALESCPQKRGVCTRVYTTTPKKPNSALRKVCRIRLTNGFEVTSYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGALDCAGVKDRKQSRSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RL3_AKKM8
Sequence: MALGLIGKKVGMTRLFDQESGAMVPVTVIDVKGNTFAQIKTEDKDGYNAIQVAFDAQKESRVAKPQAGHFKKLGIQPTKLLKEFRVEASELPAEGAKDPGVDLFSAGQWVDVIGTSKGKGFQGAMRRHNFHGSPAAHGSMMHRRTGGVGGCSTPGRVWKNQKMPGQMGNAKRTVQNLKVVAVRPEDNVILISGAVPGARGSYLVIRPAKKK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: OMPR_ECOLI
Sequence: MQENYKILVVDDDMRLRALLERYLTEQGFQVRSVANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQSNPMPIIMVTAKGEEVDRIVGLEIGADDYIPKPFNPRELLARIRAVLRRQANELPGAPSQEEAVIAFGKFKLNLGTREMFREDEPMPLTSGEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRMVEEDPAHPRYIQTVWGLGYVFVPDGSKA
What is the function of this protein?
Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (PubMed:3010044, PubMed:3536870).  Plays a central role in both acid and osmotic stress responses (PubMed:28526842, PubMed:30524381).  Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (PubMed:3533941, PubMed:3023382, PubMed:2557454, PubMed:2403550, PubMed:7592927).  Involved in acid stress response; this requires EnvZ but not OmpR phosphorylation (PubMed:29138484).  Phosphorylated by EnvZ; this stimulates OmpR's DNA-binding ability (PubMed:2656684, PubMed:2668281, PubMed:2668953, PubMed:2674113, PubMed:2558046, PubMed:7934854).  Is also dephosphorylated by EnvZ (PubMed:2668281, PubMed:2558046, PubMed:7934854).  A single OmpR protein can bind to DNA; OmpR dimers can form on the DNA in either direction, suggesting that interactions between the 2 DNA-binding domains are weak or absent (PubMed:18195018).
What are the official names of this protein?
DNA-binding dual transcriptional regulator OmpR, Transcriptional regulatory protein OmpR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTB4_CERBT
Sequence: MALPITDDDLDGLKQPYVTFSSGSASPPQSTTDAMDLEEQVLDAIKSDAFLVDWVGEDDKGNPQNLPYWRKWVITMSLALYALSTTFSSSVFGAATHVLAEEFALPAETVVLGCTSLFMVGFATGPIFWGPFSEAFGRTRPLLAGYLAFAVLQLPIADARSLTSICILRFLGGFFGAAPSSILSGILADIWSPRERGFAMPTVGAFLTIGPILGPLIGSVLVQSVLGWRWIANVVAIASFFIAVFTFPFLPETYTPLLLARRAERMRHMTRNWAYRSKSEEAQSSIGDFAERYLLRPARMLALEPILLMMTLYVSVSFGLLYNFFLAYPTSFIQERGWDQTTASLPLISILVGVIIAGALLSFTTNSRWAPNAKEGRPQETRLLLMMVGAVSLPAGMFLFAWTSSATMNPWPQILSGIPTGFGIHLINMQGMNYIIDSYKIYANSAIAANTFLRSLFAAGFPILATSMYAAIGVKWGTTILALLAVAMIPIPILFYYFGAKIRAKSKWQPPL
What is the function of this protein?
MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin (By similarity).  The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules (PubMed:11701851).  These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids (PubMed:11701851).  Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin (By similarity).
What are the official names of this protein?
Cercosporin MFS transporter CTB4, Cercosporin toxin biosynthesis cluster protein 4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. CAR1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIMO_CLOPS
Sequence: MAKYKVGMVSLGCDKNRVDSEIMLGMVQNEYELTNNPKEADIIIVNTCGFIEKAKQESINTILDMAKYKTSHNCKLLIATGCLTQRYGDELLELMPEIDIMLGVNDYAKINEAIMNFINGNNEKVKATNYSDVSINEGLRLITTDKATAYLRIAEGCDNFCTYCIIPKIRGKFRSRALESIVEEAKKLAENGVKELILIAQDTTNYGIDIYGEKKLHLVLRELAKIEGIEWIRVLYCYPEAIYDELIKEISVNDKVCNYLDLPIQHISNNVLKRMGRKTTKEEIIGKINDLRKNVPNIVLRTSLIVGFPGESCEDFNELKDFIKTIKLDKVGVFTYSREEGTPAAIMEDQIDEEVKKAREEEIMLLQKELSEEINKNKLGREYDVLIEKFNGEYYIGRSYEMAPDIDGCIYVKGNGAKKDQFCKVKIEKALEYDLVGVVCNESCK
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_MIMIV
Sequence: MQKFFVTSALPYPNNSSPHLGNLVGALLSGDVYARFKRNQGHEVIYLCGTDEYGTTTMIRARKEGVTCRELCDKYFELHKKVYDWFNIEFDVFGRTSTTKQTEITWEIFNGLYNNGYIEEKTTVQAFCEKCDMYLADTYLKGYCYHDGCRENRVISNGDQCEICQKMIDVNKLINPFCSICLTPPIQKSTDHLYLSLDKLTPLVQQYLDRVEFDSRIMAISKAWLEIGLNPRCITRDLEWGTPIPINLDPKLEKYADKVFYVWFDAPIGYYSILANERDDWREWLNSGVTWVSTQAKDNVPFHSIVFPASVIGSNIELPLIDRICGTDYLLYEGQKFSKSQGVGLFGDKVAEISPKLGINEDYWRFYLMKIRPETQDSSFNLEEFVRIVKTDLVNNIGNFINRVFSLLEKTPYRDLNYQISPEYIEFIKKYEVSMDEFKFRDGLKICLEMSSRGNKFVQSTKPWTMIKDGLDTQEIMTEAVGICWILLNLLKPIIPKSACDMLSNLDTDNQNIFCLIGGSNINIRILNIIKLPFKNIDLKQLREFIEGKN
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein: DHPS_STAAS
Sequence: MTKTKIMGILNVTPDSFSDGGKFNNVESAINRVKAMIDEGVDIIDVGGVSTRPGHEMVSLEEEMNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDMINDQWAGLYDHRMFQIVAKYDAEIILMHNGNGNRDEPVVEEMLTSLLAQAHQAKIAGIPSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLKENENARHNLS
What is the function of this protein?
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
What are the official names of this protein?
Dihydropteroate synthase, DHPS, Dihydropteroate pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the DHPS family.
Protein: YTKC_BACSU
Sequence: MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTTLKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESVQIVVTASSLGIPVPQMLVDLLETLKNKFKRKP
What are the official names of this protein?
Uncharacterized protein YtkC.
What is the protein family that this protein belongs to?
Belongs to the bacteriophage holin family. Cp-1 holin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NQO2_PARDE
Sequence: MLRRLSPIQPDSFEFTPANLEWARAQMTKYPEGRQQSAIIPVLWRAQEQEGWLSRPAIEYCADLLGMPYIRALEVATFYFMFQLQPVGSVAHIQICGTTTCMICGAEDLIRVCKEKIAPEPHALSADGRFSWEEVECLGACTNAPMAQIGKDFYEDLTVEKLAALIDRFAAGEVPVPGPQNGRFSAEALGGPTALADLKGGEAHNASVARALRLGDSIKRIDGTEVPITTPWLATQNGV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase chain 2, NADH dehydrogenase I, chain 2, NDH-1, chain 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 24 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.