PharMolix/UniProtQA huggingface dataset:
Protein: LPXH_SHEPA
Sequence: MRTLFVGDLHLSADRPDITQAFLEFLDTQLHDTDALYILGDLFEVWVGDDIAEPFVNQLVDAIKHASEKLPVYFIHGNRDFLIGEAFAKRCGMTLLPEVYSLDLYGVSTVILHGDSLCTLDKSYQRFRAFRNQGWAKWLYAHLPKSKRLGIAAKLRAKSQSSNQQKSYTIMDVEPDAVMDLLDATQTQQMIHGHTHRPDIHQLAHGKRRIVVGDWYEQGSMLSVSQDGVELIELPFGK
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL10_PSEU2
Sequence: MAIKLEDKKAIVAEVNEAAKAGLSAVVADARGVTVGAMTGLRKEAREAGVYVRVVRNTLLKRAVADTEFSVLNDVFTGPTLIAFSNEHPGAAARLFKEFAKGQDKFEIKAAAFEGKFLAANQIDVLASLPTRNEAISQLMSVIQGATSKLARTLAAVRDQKEAAAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: APTX_HUMAN
Sequence: MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHLEAVVIGRGPETKITDKKCSRQQVQLKAECNKGYVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAKNPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWTQ
What is the function of this protein?
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567).  Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567).  Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567).  Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001).  Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
What are the official names of this protein?
Aprataxin, Forkhead-associated domain histidine triad-like protein, FHA-HIT.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage (PubMed:15380105). Colocalizes with MDC1 at sites of DNA double- strand breaks (PubMed:20008512). Interaction with NCL is required for nucleolar localization (PubMed:16777843). SUBCELLULAR LOCATION: [Isoform 12]: Cytoplasm.
Protein: IRF1_RAT
Sequence: MPITRMRMRPWLEMQINSNQIPGLSWINKEEMIFQIPWKHAALHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQRKERKSKSSRDTKSKTKRKLCGDSSPDTLSDGLSSSTLPDDHSSYTAQGYLGQDLDMDRDITPALSPCVVSSSLSEWHMQMDIMPDSTTDLYNLQVSPMPSTSEAATDEDEEGKLPEDIMKLFEQSEWQPTHVDGKGYLLNEPGAQLSTVYGDFSCKEEPEIDSPGGDIEIGIQRVFTEMKNMDPVMWMDTLLGNSTRPPSIQAIPCAP
What is the function of this protein?
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (By similarity).  Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (By similarity).  Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity).  Binds to a consensus sequence in gene promoters (By similarity).  Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (By similarity).  Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (By similarity).  Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (By similarity).  Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (By similarity).  Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (By similarity).  Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (By similarity).
What are the official names of this protein?
Interferon regulatory factor 1, IRF-1.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1.
Protein: TOM91_ARATH
Sequence: MAPKKIGAGKGDSSILAKISNYDIVSQGRRAACDAVYVSKKLLKSTGKAAWIAGTTFLILAVPLILELEQDHRLGEIDFEQASLLGTPPVGAML
What is the function of this protein?
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.  Together with TOM20 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (By similarity).
What are the official names of this protein?
Mitochondrial import receptor subunit TOM9-1, Mitochondrial import receptor subunit TOM22 homolog 1, Translocase of outer membrane 22 kDa subunit homolog 1, Translocase of outer membrane 9 kDa subunit TOM9-1.
What is the protein family that this protein belongs to?
Belongs to the Tom22 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type II membrane protein.
Protein: Y1347_AQUAE
Sequence: MGFLERIKKLFSKEEEKQEESILSNPLERLKKGDIIEIDGETWEVTDVALYDYGASKEKEWEIRSASRRGFLSLEEGKIYFFEEIDPEELEPDPGEHFRKYGKPPEYVTYKGKRYRLKYAGKAKYIKNLESYPVTIWEFRSEDGEMIDLEIWDEYEIEAYKGRELQEWEIESILPR
What are the official names of this protein?
Uncharacterized protein aq_1347.
Protein: PPR94_ARATH
Sequence: MQRSISLTAKRLFVHWNLQGIGNPPTVPSFFNLCGSGCWERSFASASGDYREILRNRLSDIIKVDDAVDLFGDMVKSRPFPSIVEFNKLLSAVAKMNKFELVISLGEQMQTLGISHDLYTYSIFINCFCRRSQLSLALAVLAKMMKLGYEPDIVTLSSLLNGYCHSKRISDAVALVDQMVEMGYKPDTFTFTTLIHGLFLHNKASEAVALVDQMVQRGCQPDLVTYGTVVNGLCKRGDIDLALSLLKKMEKGKIEADVVIYNTIIDGLCKYKHMDDALNLFTEMDNKGIRPDVFTYSSLISCLCNYGRWSDASRLLSDMIERKINPNVVTFSALIDAFVKEGKLVEAEKLYDEMIKRSIDPDIFTYSSLINGFCMHDRLDEAKHMFELMISKDCFPNVVTYSTLIKGFCKAKRVEEGMELFREMSQRGLVGNTVTYTTLIHGFFQARDCDNAQMVFKQMVSVGVHPNILTYNILLDGLCKNGKLAKAMVVFEYLQRSTMEPDIYTYNIMIEGMCKAGKVEDGWELFCNLSLKGVSPNVIAYNTMISGFCRKGSKEEADSLLKKMKEDGPLPNSGTYNTLIRARLRDGDREASAELIKEMRSCGFAGDASTIGLVTNMLHDGRLDKSFLDMLS
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g62910.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: CYGPB_GLOPU
Sequence: GGSVPCIETCVWTGCFLVPGCSCKSDKKCYLN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide glopa B.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: PHCA_SYNPW
Sequence: MKTPLTEAVSAADSQGRFLSSTEVQAASGRFNRAAASLEAAKALSAKADALVNGAAQAVYNKFPYTTQMEGSNYSTTPEGKAKCSRDVGYYLRMITYCLVAGGTGPMDDYLIAGLDEINRTFELSPSWYVEALKYIKSNHGLSGDAATEANSYIDYAINALI
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex (phycobilisome, PBS).  Phycocyanin is the major phycobiliprotein in the PBS rod.
What are the official names of this protein?
R-phycocyanin alpha subunit.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Part of the phycobilisome rod.
Protein: SECG_THEVO
Sequence: MASDKKSEGFQSGAGLIRYFEEEEIKGPALDPKLVVYIGIAVAIMVELAKIFWPP
What is the function of this protein?
Involved in protein export.  The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).
What are the official names of this protein?
Preprotein translocase subunit SecG, Protein transport protein Sec61 subunit beta homolog.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: TDA2_YEASZ
Sequence: MQIEIKDGRSDNSPLPERKLVTLIQESYDSLKDDNEINLSTESTSNLLIKLVLEKLEKHSSLYKYIASVTTLNIEGLNEENANFSLKNDIGASWESKKRWYIQL
What are the official names of this protein?
Topoisomerase I damage affected protein 2.
What is the protein family that this protein belongs to?
Belongs to the TDA2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection. Note=Concentrates at cytoplasmic punctate structures and localizes at the mating projection tip.
Protein: FLGI_ECO81
Sequence: MIKFLSALILLLVITAAQAERIRDLTSVQGVRQNSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASLPPFGRQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAVIERELPSQFGVGNTLNLQLNDEDFSMAQQIADTINRVRGYGSATALDARTIQVRVPSGNSSQVRFLADIQNMQVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQANVSQPDTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSASLNNVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: MPRA_MYCBO
Sequence: MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
What is the function of this protein?
Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host.  Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).  MprB/MprA up-regulates expression of mprA and pepD.
What are the official names of this protein?
Response regulator MprA, Mycobacterial persistence regulator A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP21A_HUMAN
Sequence: MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQNQ
What is the function of this protein?
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis.  Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:10602386, PubMed:16984992, PubMed:22014889, PubMed:27721825).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791).
What are the official names of this protein?
Steroid 21-hydroxylase, 21-OHase, Cytochrome P-450c21, Cytochrome P450 21, Cytochrome P450 XXI, Cytochrome P450-C21, Cytochrome P450-C21B.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: P9_RGDV
Sequence: MAGKLQDGVAIAKIKETINLFCEYSFGDLVNNRREIVGRVHDARKNAALAWPDLIMNCFLHSASHYGVVKFLLDIALSTRFGDFTLLGVSSQNYPFYDLHVVMTKAFCNLDFAKDEYLMINDSFSSMMSAFLDEEGVHSAMSMELGIHDIEDRFVLRTKRLFYIIHEYHMSLDEIEPWLEKLPDASGGTLLNQKSKEQMRVIFSNAKVRIANSINLYVTTHTNSYNEYVREVAEYVADLWNIQTTTNTQGHENELAAEDFGVLASSSQMNGTKSELGDSVIKSDGNEVKLEPAMFTRNDDEEELAGSEFTSLLSDDGRMG
What is the function of this protein?
Minor outer capsid protein.
What are the official names of this protein?
Minor outer capsid protein P9, Protein Pns10.
What is the protein family that this protein belongs to?
Belongs to the phytoreovirus minor outer capsid protein P9 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Found in the peripheral regions of spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RPOA_STAAE
Sequence: MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: LUXO_VIBC1
Sequence: MVEDTASVAALYRSYLTPLGIDINIVGTGRDAIESLNHRIPDLILLDLRLPDMTGMDVLHAVKKSHPDVPIIFMTAHGSIDTAVEAMRHGSQDFLIKPCEADRLRVTVNNAIRKATKLKNEADNPGNQNYQGFIGSSQTMQQVYRTIDSAASSKASIFITGESGTGKEVCAEAIHAASKRGDKPFIAINCAAIPKDLIESELFGHVKGAFTGAANDRQGAAELADGGTLFLDELCEMDLDLQTKLLRFIQTGTFQKVGSSKMKSVDVRFVCATNRDPWKEVQEGRFREDLYYRLYVIPLHLPPLRERGKDVIEIAYSLLGYMSHEEGKSFVRFAQDVIERFNSYEWPGNVRQLQNVLRNIVVLNNGKEITLDMLPPPLNQPVVRQSVAKFIEPDIMTVSDIMPLWMTEKMAIEQAIQACEGNIPRAAGYLDVSPSTIYRKLQAWNSKDEKQNV
What is the function of this protein?
Acts negatively to control the expression of luminescence.  At low cell density, LuxO is phosphorylated, and together with sigma-54, causes repression of the luxCDABEGH operon.  This repression could be indirect, LuxO could activate a negative regulator of luminescence.  At high cell density, LuxO is dephosphorylated and inactive, therefore the luxCDABEGH operon is not repressed and light is emitted.  LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype.
What are the official names of this protein?
Luminescence regulatory protein LuxO.
Protein: YCAR_SALPB
Sequence: MDHRLLEIIACPVCNGKLWYNQEQQELICKLDNLAFPLRDGIPVLLENEARALTSDESKS
What are the official names of this protein?
UPF0434 protein YcaR.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: LEPA_SYNFM
Sequence: MTKIRNFSIIAHIDHGKSTLADRLIQRAGLVTDRQFRDQILDNMDIERERGITIKSQTVTLPYRSRNGEEVELNLIDTPGHVDFSYEVSRALASCEGVLLLVDASQGVQAQTLANLYAAMEHDLTIIPVINKIDLLSADIENTRAQIESELGLDSSQAVLCSAKEGRGIDDVLEAVVDRIPPPSGKLDAPLSALIFDAHYDSFRGTIVACRVFDGSVRPGDVIRFMSNGATYKVEEVGVFRLSREPKKELRAGMVGYVISGVKTVSDTRVGDTITLDSNPVPAPLPGFKEVKPVVFSSIYPISSDDYLSLADSLEKYKLNDAALIYQKDSSVALGQGFRCGFLGLLHLEIVQERLEREYDQSIIMTFPSVQYVLTLEDGSTTMVDNPQYYPDPIRIRTSAEPFIKASIIIPERYMGAVMKLCLDKRGVNPRFNYPTPGRIEISMEMPLAEVVFDFYDKLKTVTQGYGSFDYDLIEHRVSDLVKLDILVNSEKVDALSLIVHRERAREWAVQVCDRLKEEIPRHQFKIAIQGAIGGKIIARSTVNAFRKDVTAKCYGGDISRKRKLLEKQKKGKKRMKMVGSVMIPQSAFVAVLKADNE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SGT1_MOUSE
Sequence: MAAAAAGPASSQRLFQSFSDALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAEGQKLDSTDTNFDTWIKRCQEIQNGSESEVSASQRTQSKIKYDWYQTESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLEGQGDEPTPKQFTADVKNMYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKQY
What is the function of this protein?
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
Protein SGT1 homolog, Suppressor of G2 allele of SKP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SGT1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates the to nucleus upon heat shock, requiring S100A6.
Protein: Y4561_PSEPK
Sequence: MSGTKDKAKGLANEAIGNVKQGVGKVTDNEKLRAEGKAQELKGEAQQVKGNVKDAVKKP
What are the official names of this protein?
UPF0337 protein PP_4561.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: UCP1_OCHDA
Sequence: MVGTTATDVAPTMGVKIFSAGVAACLADVITFPLDTAKVRLQIQGECQTTSGIRYKGVLGTITTLAKTEGPLKLYSGLPAGLQRQISFASLRIGLYDTVQEFWGGEEATPSLRSKICAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGLKPRYTGTYNAYRIIATTESLSTLWKGTTPNLLRNIIINCTELVTYDLMKGALVRNDILADDVPCHLLSALIAGFCTTLLSSPVDVVKTRFINSPQGQYTSVPSCAMSMLTKEGPTAFFKGFAPSFLRLASWNVIMFVCFEKLKRELMKSRQTVDCAT
What is the function of this protein?
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance.  Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane.  However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs.  Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP.  Regulates the production of reactive oxygen species/ROS by mitochondria.
What are the official names of this protein?
Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ISPF_PSEU2
Sequence: MRIGHGYDVHRFAEGDFITLGGVRIAHGFGLLAHSDGDVLLHALSDALLGAAALGDIGKHFPDTDPQFKGADSRVLLRHVLTLIHGKGWKVGNVDATIVAQAPKMAPHIDAMRALIAEDLQVEPDQVNVKATTTEKLGFTGREEGIAVHAVALLLRA
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: MMM1_COPC7
Sequence: MTNIIFSLQPTFTQGLILGQLSVLVLLGLILKYLFLDSTKNPFETTSYHPQFDRKPARKQQAQDSQSQSEIDDVESLDWFNLLLQQVANVYRSKLRGDLAGAEGDETARQRIEAFANKIRPAGFLDLIKIHSVDLGAGAPTLFNARIRESDPNDPDSPPEIEFDAVYEDTLSLSLSTSYLFNYPTASFARLPISLTISLSQFKSSIRVIPPTPDSVAPVLTFTISPDFVLDLTTTSLMGSRAKLANVPKLHELIQHQVRRVLGGRATWKVVLPGLASVAEAKQQVLKQEQEESKRQEEA
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Maintenance of mitochondrial morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the MMM1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.