PharMolix/UniProtQA huggingface dataset:
Protein: NAGB_SHIF8
Sequence: MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMIMVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMELKVKTLRYFNELEAENIKGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: RL20_PARD8
Sequence: MPRSVNHVASRAKRKRILKLTRGYYGARKNVWTVAKNTWEKGLTYAFRDRRNKKRNFRALWIQRINAAARMEGLSYSRLMGALHAAGIEINRKVLADLAVNHPEAFKAIVAKVK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: FOLD_ECO5E
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDALNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TVA14_HUMAN
Sequence: MSLSSLLKVVTASLWLGPGIAQKITQTQPGMFVQEKEAVTLDCTYDTSDPSYGLFWYKQPSSGEMIFLIYQGSYDQQNATEGRYSLNFQKARKSANLVISASQLGDSAMYFCAMRE
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 14/delta variable 4.
What are the subcellular locations of this protein?
Cell membrane.
Protein: KGUA_RICPR
Sequence: MKFKNKGLIIILSSPSGTGKSSLAKELLKIDNNLRLSISVTTRKPRLGEVDGINYYFKSDREFKTLVKQNKFLEYAKIYNDYYGTPKEYVKMLLKQGFDVLFDIDWQGVRSIKKNTNNVITIFILPPSIEILEQRLRNRATDNEETIKLRMQSAQNEISHANEYDYVVINDDFSQTLKKIHEIIVAERAKNFAYHEY
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_MYCAP
Sequence: MIAIIETGGKQILVKEGETIFIEKIEGAEGSKVTFDKVLLLDNKIGKPYVESAKVIGEIQKQGKAKKIVVYRHNAKSTHKRKLGHRQPYTRVKITGIVG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: HIS4_MARN8
Sequence: MLIIPAIDLKDGKCVRLRQGRMEDSTVFGDDPVDMATKWVDAGARRLHLVDLNGAFAGEPVNGEIVKAIAVKYPNLPIQIGGGIRSAETIEAYLKAGVQWVIIGTKAVKEPEFVTEMCKEFPGHIIVGLDAKDGRVATDGWAEVSEVMAVDLAKRFANDGVSSIVYTDIARDGMMQGVNVEATAKLAEEGGIPVIASGGVTNMDDLKRLATVADTGVIGAITGRAIYEGTLDVAEAQAYCDSLKN
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VACHT_TORMA
Sequence: MAVGQAKAAMGKISSAIGERSKRISGAMNEPRRKRKILLVIVCIAMLLDNMLYMVIVPIIPNYLETIRTYKLVYITTPSNGTNGSLLNSTQRAVLERNPNANEDIQIGVLFASKAILQLLSNPFTGTFIDRVGYDIPLLIGLTIMFFSTITFAFGESYAILFAARSLQGLGSAFADTSGIAMIADKYTEESERTQALGIALAFISFGSLVAPPFGGVLYQFAGKWVPFLVLSFVCLLDGILLLMVVTPFASRTRVNTLQGTPIYKLMIDPYIAVVAGALTTCNIPLAFLEPTISNWMKKTMNASEWQMGITWLPAFFPHILGVYITVKLAAKYPNYQWLYGAVGLVIIGASSCTIPACRNFEELIIPLCALCFGIALVDTALLPTLAFLVDIRYVSVYGSVYAIADISYSVAYALGPIMAGQIVHDLGFVQLNLGMGLVNILYAPGLLFLRNVCQMKPSLSERNILLEEGPKGLYDTIIMEERKEAKEPHGTSSGNHSVHAVLSDQEGYSE
What is the function of this protein?
Involved in acetylcholine transport into synaptic vesicles.
What are the official names of this protein?
Vesicular acetylcholine transporter, VAChT, Vesamicol-binding protein.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Vesicular transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL34_NOSP7
Sequence: MKRTLGGTSRKRKRTSGFRARMRTPDGRNVIRARRKKGRHRLSV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PYRB_THEFY
Sequence: MQHLLSAGDLTRDEALLILDTARELSQVSERSVKKLPTLRGRTVVNLFYEDSTRTRISFEAAAKRMSADVINFSARGSSVSKGESLKDTALTLQAMGADGVVIRHSAPGAARRLADWVDGVVINAGDGTHEHPTQALLDAYTMRERLGRVEGLRVAIVGDIRHSRVARSNVLLLTTLGAEVTLVAPPTLLPVSVDTWPCAVSYDLDEVLPKSDVVMMLRVQAERMHSSFFPSAREYSRRYGLDADRLARMADHAIVMHPGPMVRGMEISAEVADSARSTVTEQVTNGVSVRMAVLYLLLGGAIHRPGNQGEPR
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: EFTS_BURP6
Sequence: MAAITASMVAELRAKTDAPMMECKKALTEADGDMAKAEELLRVKLGNKASKAASRVTAEGVVASFVGANAGALVELNCETDFVAKNDDFNAFAKTVAELVATQNPADVAALSALPLDGKTVDEVRLALVGKIGENISIRRFVRFETSNKLATYLHGSRIGVIVEYTGAQEQVGKDVAMHVAAMKPVSLSADEVPADLIEKERRVAEQKAAESGKPAEIVAKMVDGSVQKFLKEVSLLNQPFVKNDKQTIEQMLKAADAAVQKFALFVVGEGIEKRQDDFAAEVAAQVAAAKQQ
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSXD_ECO24
Sequence: MVFRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLTGLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAVNIPGFIDAIQVIFSGHTASGGDMNTLRLGIDGISQATPLDTFKTSVRAGHSVEQIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIRWHIPLSFLVTLTLCATLGWLFSPETLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHRKG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rsx electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AT18C_ARATH
Sequence: MSSTVSNPQGILQPGSFLLPESESMKKEEAELVSVCWNQDSSCFAAGTSHGFRIYNCEPFKETFRRELKDGGFKIVEMLFRSNILALVGGGPNSQYPSSKVLIWDDHQSRCISEFAFRSEIRAVKLRRDRIVVVLEHKIYVYNFMDLRLLHQIETQANPRGLCCLSHHSNTSVLACPGLNRGEIRVEHFGLNMVQIINAHDSSIACMTLTLDGLLLATASTKGTLIRIFNTMDGTRLQEVRRGVDRADIYSIALSPNVQWLAVSSDKGTVHIFSLRVRVVGEDSYSTENGALLTQQNYSNSLQGLVSPTIGTNPGSSLSFMRGVLPKYFSSEWSYAQFHVSEVTQFFAAFGSNNTVAIIGMDGSFYRCSFDPVNGGEMGQLEYIHFMKMDNRP
What is the function of this protein?
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Required for autophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 18c, AtATG18c.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Note=Peripheral membrane protein of pre-autophagosomal structure (PAS) and vacuole.
Protein: Y5374_ARATH
Sequence: MKEMMGVVGIILVVSSCCLSLLDAQEITHPTDVSALQYVHRKLKDPLNHLQDWKKTDPCASNWTGVICIPDPSDGFLHVKELRLLNMNLTGQLAPELGLLSNLTILNFMWNDLTGQIPPELGNLTHLIFLLLSGNQLTGSLPQELGSLSNLLILQIDYNEISGKLPTSLANLKKLKHFHMNNNSITGQIPPEYSTLTNVLHFLMDNNKLTGNLPPELAQMPSLRILQLDGSNFDGTEIPSSYGSIPNLVKLSLRNCNLEGPIPDLSKSLVLYYLDISSNKLTGEIPKNKFSANITTINLYNNLLSGSIPSNFSGLPRLQRLQVQNNNLSGEIPVIWENRILKAEEKLILDLRNNMFSNVSSVLLNPPSNVTVKLYGNPVCANVNAGKLADLCGISTLEVESPATSSETISTGDCKRQSCPVSENYDYVIGSPVACFCAAPLGIDLRLRSPSFSDFRPYKVSYMLDVASPKNLGINPYQISIDTFAWQSGPRLFMNMKIFPEYSELNSKFNSTEVQRIVDFFATFTLNTDDSLGPYEIISINTGAYKDVTIIFPKKSGMSIGVSVGIIIGAIAFFLVLSSLALVFFIKRSKRKRKTREVDMEQEHPLPKPPMNMESVKGYNFTELDSATSSFSDLSQIGRGGYGKVYKGHLPGGLVVAVKRAEQGSLQGQKEFFTEIELLSRLHHRNLVSLLGYCDQKGEQMLVYEYMPNGSLQDALSARFRQPLSLALRLRIALGSARGILYLHTEADPPIIHRDIKPSNILLDSKMNPKVADFGISKLIALDGGGVQRDHVTTIVKGTPGYVDPEYYLSHRLTEKSDVYSLGIVFLEILTGMRPISHGRNIVREVNEACDAGMMMSVIDRSMGQYSEECVKRFMELAIRCCQDNPEARPWMLEIVRELENIYGLIPKEEKPYSSPSVQSSASGMSGFAVASPRSSYTTFSEFTANQLVSGVIPSIAPR
What are the official names of this protein?
Probable LRR receptor-like serine/threonine-protein kinase At5g37450.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ENV_HV196
Sequence: MRVRGMQRNWQTLGNWGILFLGILIICSNADKLWVTVYYGVPVWKEATPTLFCASDAKAYEKEVHNVWATHACVPTDPNPQEVEMENVTENFNMWKNNMVEQMHTDIISLWDESLKPCVELTPLCVTLNCTDYKGTNSTNNATSTVVSPAEIKNCSFNITTEIKDKKKKESALFYRLDVLPLNGEGNNSSTEYRLINCNTSTITQTCPKVTFEPIPIHYCAPAGFAILKCKDKRFNGTGPCKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENITDNTKNIIVQLNETVQINCTRPNNNTRKSIHMGPGKAFYTTGDIIGDIRQAHCNISGEKWNMTLSRVKEKLKEHFKNGTITFKPPNPGGDPEILTHMFNCAGEFFYCNTTKLFNETGENGTITLPCRIKQIINMWQKVGKAIYAPPIAGSINCSSNITGMILTRDGGNNTHNETFRPGGGDMRDNWRSELYKYKVVQIEPLGIAPTRARRRVVQREKRAVGLGAVFFGFLGAAGSTMGAASITLTVQARQLLSGIVQQQSNLLRAIEAQQHLLQLTVWGIKQLRARILAVERYLKDQQLLGIWGCSGKLICTTNVPWNSSWSNKSWEEIWNNMTWMEWEKEIGNYSDTIYKLIEESQTQQEKNEQDLLALDKWASLWNWFDITKWLWYIKIFIMIIGGLIGLRIAFAVLSVVNRVRQGYSPLSFQTLIPTSRGADRPEGIEEEGGEQDKNRSVRLVSGFLALAWDDLRNLCLFSYRQLRNLILIVTRILERGLRGGWEALKYLWNLVQYWSQELKNSAISLLNTTAIAVAGGTDRIIEIGQRAFRALLHIPRRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: ENO_PROA2
Sequence: MPLITNVIARQILDSRGNPTVEVDVLTESSFGRAAVPSGASTGIHEAVELRDGDREVYLGKGVLKAVENVNTVINDALEGMLVTEQTEIDKLLLSLDGTPNKSKLGANALLGVSLACAKAAAEYSGLPLFRYIGGTLANTLPVPMMNVLNGGAHADNNVDFQEFMIMPIGFSSYSDALRCGAEVFHALKALLKSKGLSTAVGDEGGFAPDLASNEEAIELVIEAVGKAGYKAGSPTNAGGLGDAHVMIALDPASSEFYDTDKKKYIFKKSSGQELDSAEMASYWENWAGKYPIISIEDGMAEDDWEGWKILTDKIGSRVQLVGDDLFVTNSIRLADGIERKVGNSILIKVNQIGTLTETLQAIDLAKRNGYTSVISHRSGETEDSTIAQIAVATNAGQIKTGSLSRSDRMAKYNELLRIEEELGDEACYPGIRAFRV
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PPK1_NEIMB
Sequence: MPEQNRILCRELSLLAFNRRVLAQAEDQNVPLLERLRFLCIVSSNLDEFFEVRMAWLKREHKRCPQRRLDNGKMPSETIADVTEAARSLIRHQYDLFNNVLQPELAQEGIHFYRRRNWTDTQKKWIEDYFDRELLPILTPIGLDPSHPFPRPLNKSLNFAVELDGTDAFGRPSGMAIVQAPRILPRVVPLPSELCGGGHGFVFLSSILHAHVGKLFPGMNVKGCHQFRLTRDSDLTVDEEDLQNLRAAIQNELHDREYGDGVRLEVADTCPAYIRDFLLAQFKLTAAELYQVKGPVNLVRLNAVPDLVNRPDLKFPTHTPGRLKALGKTASIFDLVRQSPILLHHPYQSFDPVVEMMREAAADPAVLAVKMTIYRTGTRSELVRALMKAALAGKQVTVVVELMARFDEANNVNWAKQLEEAGAHVVYGVFGYKVHAKMALVIRREDGVLKRYAHLGTGNYHQGTSRIYTDFGLITADEQITADVNILFMEITGLGKPGRLNKLYQSPFTLHKMVIDRIARETEHAKAGKPARITAKMNSLIEPTVIEALYRASAAGVQIDLIVRGMCTLRPGVKGLSENIRVRSIVGRQLEHARVYYFHNNGTDDTFISSADWMGRNFFRRIETATPITAPELKKRVIHEGLTMALDDNTHAWLMQPDGGYIRAAPAEGESEADLQNDLWTLLGG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: MTNA_DROSI
Sequence: MSLQSIKYSRGSLEILDQLLLPGQSKYVVVRGVEDGWKVINKMQVRGAPAIAIVGCLSLAVEINPEDFENKKSLRQEIEGKLNYLVSARPTAVNMKIAADELITLANELYKDEATDVTQMKHRFLDATEAMLKKDIADNRAIGANGAQAILQRVAKAGKTPAGSTGSVRVLTHCNTGSLATAGYGTALGVVRQLAELGKLEHVYCTETRPYNQGARLTAYELVHEKFPATLVLDSMVAALLRAKNVAAVVVGADRVASNGDTANKIGTYQIAVVAKHHDVPFYVAAPLTSIDLAIPGGDHIIIEERPDREMTHVGEHRIAAPGINCWNPAFDVTPASLITGIITERGVFKPAELKEAITKLLES
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BAIP2_BOVIN
Sequence: MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAIGNKQGELESYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPNKIPDRAVQLMQQMGNSNGSILPSGLSASKSNLVISDPIPGAKPLPVPPELAPFVGRLSAQENAPVMNGVSGPDSEDYNPWADRKATQPKSTSPPQSQSKLSDSYSNTLPVRKSVAPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDNDGGDRLHMSLQQGKSSSTGNLLDKEDLALPPPDYGTSSRAFPTQTAGAFKQRPYSVAVPAFSQGLDDYGARAVSSADVEVARF
What is the function of this protein?
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins.  Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling.  Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex.  Plays a role in neurite growth.  Acts syngeristically with ENAH to promote filipodia formation.  Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.  Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity).
What are the official names of this protein?
Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI-associated protein 2, BAI1-associated protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity).
Protein: POF14_SCHPO
Sequence: MLQFSFQNCKTHTCYMNTSVNEHLDQDESFLRILIDTRKKIRSSYFKPQTFDEFVHCLARVRAMKRLVSICSNFDEEDNWNGVWNTLVVDGDSHASAMIDYEGLLDKCSLSRNLLELINDYAEYTTQVLPFRKIPSSDNLDSSLNLTVASPKSNLYYRYSSESPKYAKILDCPDEILQLIFSYCYDASYIEKLPFAFSYRKQRHTLIHDLPNTCLRFKKILSPRNVSFWKRLLKVHKKNPNSAVTCSESINTSAVAKFTDIPTIIPIFLDPSYQSYAAKTIHSDTSSLASSIIQTGDGTQSCDESTYIELACNLVGRCVLCNRIPKLTKFKDCITSFYRPSVATNICDQCLEAIIDFYEPVSRYKFDVMKDRLGVGYISRPGQKFPSWLSEHVQLARDEEKAFKSIYHSQGEFARSLFRLFRAQLAELCEQ
What is the function of this protein?
Expression is induced during oxidative stress.  Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively regulating ergosterol synthesis via direct binding to the squalene synthase erg9.
What are the official names of this protein?
F-box protein pof14.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Associated with vesicle-like and endoplasmic reticulum (excluding a nuclear rim) structures.
Protein: RIBC1_RAT
Sequence: MYKLDLAPDPKELAAIEARRNREKERQCRFFNVRNRVMGVDVEALNYQVEERKFREAIERSKDMAYGAKHAHYDLVAQMLEKEEAERACRLSKRVQDFREQRQQFKNGHEFDFWDPDHVQEFQVPYYENEAYFGPASMQYFLGEDLERASHLRMQQEQLRYNLEKQLQEQQAAREEEARAALLSDQLRLAADTRAAELARLEESCRAAMRTAMANANKAQAAKQALLQRREQQQQQEANLAEIKKQVTSDLLTENPQVAQRPSAPHRVLPYCWKGMTAEQRAAIRKTQENQRQEKKEQRQAEKLVEAEWGSQSKRLAEAALELEEQERELCAEFRRGLGSFNRELAKEQHAQQNYLNSVIYTNQPTSHYYLQFNTSSR
What are the official names of this protein?
RIB43A-like with coiled-coils protein 1.
What is the protein family that this protein belongs to?
Belongs to the RIB43A family.
Protein: IFNT4_SHEEP
Sequence: MAFVLSLLMALVLVSYGPGGSLGCYLSQRLMLDARENLKLLDRMNRLSPHSCLQDRKDFGLPQEMVEGDQLQKDQAFPVLYEMLQQSFNLFYTEHSSAAWDTTLLDQLCTGLQQQLDHLDTCRDQVMGEKDSELGNMDPIVTVKKYFQGIHDYLQEKGYSDCAWEIVRVEMMRALTVSTTLQKRLTKMGGDLNSP
What is the function of this protein?
Paracrine hormone primarily responsible for maternal recognition of pregnancy.  Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium.  This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity.  This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus.  In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties.  In contrast with other IFNs, IFN-tau is not virally inducible.
What are the official names of this protein?
Interferon tau-4, IFN-tau-4, Antiluteolysin, P3, Trophoblast antiluteolytic protein, Trophoblast protein 1, TP-1, Trophoblastin.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the uterine lumen.
Protein: RL33_MESH2
Sequence: MAREGLTLRCTDCKMENYITKKNKKTKPEKIEVKKHCHKCNKHTLHREKK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: MLTC_HISS2
Sequence: MKKYIVFAIIPFLFACSSSTLNDDYDEAFAKDTQGLDILTGQFSHNIDQIWGVNELLVASRKDYVKYTDNFYTRSHISFDEGSIMIETLGDKSRLYHSIIHTLLMGADAKGIDLFTSGDVPISSRPFLVGLVVDHKGKQVKNIATASNFANYLLQNKLQTRYLTNGNPVQYVIIPMVANHVAVRAQRYLPLIRKAAGRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGRDVFRLKGLNGQPSKKYLFNPAKNIDTGVAYLTLLRDKYLDGITNPTSKRFAMISAYNSGAGAVLRVFHNDRDIAINKINRLYPEQVYRILTTMHPSEQARNYLLKVDKAQKSYRVIKNSESDLP
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.