PharMolix/UniProtQA huggingface dataset:
Protein: RTEL1_MUSSP
Sequence: MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAISSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIPKIIYASRTHSQPTQVIRELRNTAYRPKVCVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGELQQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMDIIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRKQGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEKQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYLKVYDNFGHAIRDVAQFLRVAQKTMPLPVPQAVTSSVSEGEIALKDATLSSYSLSTRKAISLDVHVPSLRQKSIGLPAAGDPESSLCGEYEQQTFSAQQRPMGLLAALEYNEQKAGASEEQALGSSTPSLRFEKRLSTEQKGGRKKVRLVNHPEEPMAGTQAGRAKMFMVAVKQALSQANFDTFTQALQHYKSSDDFEALVASLTCLFAEDPKKHTLLKGFYQFVRPHHKQQFEDICFQLTGQRCGYQPGKSELESKLTLSEGVDRQLDPGQHLNHGQPHLSAHPTSKGHTSHCTKVGCAVEKPGQPAVSDYLSDVHKALGSASCNQLTAALRAYKQDDDLDKVVAVVAALTTAKPEHLPLLQRFGMFVRRHHKPQFLQTCADLMGLPTTGKDLELEGPRDESPTVPPELTHEDLKPGPSMSKKPEKTQSKISSFFRQRPDESVRSDDTTPKPMQLPPRLPHELMKPHRSKQ
What is the function of this protein?
ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability.  Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis.  Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.  Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
What are the official names of this protein?
Regulator of telomere elongation helicase 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD3/XPD subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with PCNA within the replication foci in S-phase cells.
Protein: NQO1_MOUSE
Sequence: MAARRALIVLAHSEKTSFNYAMKEAAVEALKKRGWEVLESDLYAMNFNPIISRNDITGELKDSKNFQYPSESSLAYKEGRLSPDIVAEHKKLEAADLVIFQFPLQWFGVPAILKGWFERVLVAGFAYTYAAMYDNGPFQNKKTLLSITTGGSGSMYSLQGVHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARMQILEGWKKRLETVWEETPLYFAPSSLFDLNFQAGFLMKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK
What is the function of this protein?
Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors.  In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (PubMed:8999809) (By similarity).  Regulates cellular redox state primarily through quinone detoxification.  Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms.  In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity).  Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity).  Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions.  Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity).
What are the official names of this protein?
NAD(P)H dehydrogenase [quinone] 1, Azoreductase, DT-diaphorase, DTD, Menadione reductase, NAD(P)H:quinone oxidoreductase 1, Phylloquinone reductase, Quinone reductase 1, QR1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RL22_PARMW
Sequence: MTTSSTTAPIAQAHGRFIRGSVSKVRRVLDQIRGRTYRDALIMLEFMPYRSTGPITKVLRSAVANAEHNLGLDPASLVISSASADMGPSMKRYRPRAQGRAFQIKKQTCHISIAVAAQPDS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: PARE_MYCGE
Sequence: MKSNYSATNIKILKGLDAVKKRPGMYIGSTDSKGLHHMLWEILANSVDEVLAGYATNITVTLDLNNTITVSDDGRGIPYEIHQDSNISTIDTVFTFLHAGGKFDDQSYKLAGGLHGVGASVVNALSDHLEVTVKRNGQIYQSVYQAGGKIIQKAKKIGDTTSHGTTVSFHADPKVFKKAQFDSNIIKSRLKELSFLFAKLKLTFTDQKTNKTTVFFSTSGLVQFLDEINNTVETLGQKTLIKGEKDGIEVEVVFQFNQSDQETILSFANSIKTFEGGSHENGFCLAISDVINSYCRKYNLLKEKDKNFQLSEIRQGLNAIIKVNLPEKNIAFEGQTKSKLFSKEVKNVVYELVQQHYFQFLERNNNDAKLIIDKLLNARKIKEQIKQQRELKKSLSSPQKEKILFGKLAPCQTKKTSEKELFIVEGDSAGGTAKMGRDRIFQAILPLRGKVLNVEKINNKKEAITNEEILTLIFCIGTGILTNFNIKDLKYGKIIIMTDADNDGAHIQILLLTFFYRYMQPLIELGHVYLALPPLYKLETKDRKTVKYLWSDLELESVKLKLNNFTLQRYKGLGEMNADQLWDTTMNPTTRKLVQVKLDDLINAEKQINIFMGEKSDLRKHWIEANINFSVEN
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit B, Topoisomerase IV subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Protein: AROK_PSEA8
Sequence: MVNLILVGPMGAGKSTIGRLLAKELHLAFKDSDKEIEQRCGANIPWIFDVEGEVGFREREQAMLTELCAADGMVIATGGGAVMRDGNRQVLRAGGRVVYLHASVEHQIARTARDRNRPLLQKPNPGQILRDLMALRDPLYREIADVVVETDERPPRLVVQEILERLRKLPPR
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYRS_QUEIL
Sequence: MALKLLTSLPMYNFSRVPVSSKDPILLVTSRTRNGYLARPVQCMVANKVSTSPDILRRSANYQPSIWNHDYIESLRIEYVGETCTRQINVLKEQVRMMLHKVVNPLEQLELIEILQRLGLSYHFEEEIKRILDGVYNNDHGGDTWKAENLYATALKFRLLRQHGYSVSQEVFNSFKDERGSFKACLCEDTKGMLSLYEASFFLIEGENILEEARDFSTKHLEEYVKQNKEKNLATLVNHSLEFPLHWRMPRLEARWFINIYRHNQDVNPILLEFAELDFNIVQAAHQADLKQVSTWWKSTGLVENLSFARDRPVENFFWTVGLIFQPQFGYCRRMFTKVFALITTIDDVYDVYGTLDELELFTDVVERWDINAMDQLPDYMKICFLTLHNSVNEMALDTMKEQRFHIIKYLKKAWVDLCRYYLVEAKWYSNKYRPSLQEYIENAWISIGAPTILVHAYFFVTNPITKEALDCLEEYPNIIRWSSIIARLADDLGTSTDELKRGDVPKAIQCYMNETGASEEGAREYIKYLISATWKKMNKDRAASSPFSHIFIEIALNLARMAQCLYQHGDGHGLGNRETKDRILSLLIQPIPLNKD
What is the function of this protein?
Involved in monoterpene (C10) biosynthesis.  The major product is myrcene followed by minor amounts (1. 2%) of the cyclic monoterpene limonene.
What are the official names of this protein?
Myrcene synthase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HTF_ZOPAT
Sequence: QLNFSPNW
What is the function of this protein?
Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).
What are the official names of this protein?
Hypertrehalosaemic factor, HOTH, Hypertrehalosaemic neuropeptide.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLA3_MAIZE
Sequence: MGVYTFVCRNNGGEWTAKQHSGEIEASAATPYELQRRLVAAASAADSRYGVQSSFSMVTPSSAVFQVIVGAVGGGAMMVSGGGGGGAAASGGAAAEAPKEEKKEEEKEESDDDMGFSLFD
What is the function of this protein?
Plays an important role in the elongation step of protein synthesis.
What are the official names of this protein?
60S acidic ribosomal protein P3, P1/P2-like, P3A.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Protein: ZEB2_HUMAN
Sequence: MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM
What is the function of this protein?
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212).  Represses transcription of E-cadherin (PubMed:16061479).  Represses expression of MEOX2 (PubMed:20516212).
What are the official names of this protein?
Zinc finger E-box-binding homeobox 2, Smad-interacting protein 1, SMADIP1, Zinc finger homeobox protein 1b.
What is the protein family that this protein belongs to?
Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TRPC_PROMS
Sequence: MEIRRRPPNPTVRVENLEYAVPHREAQAKNILEEIVWHKDIEIKNFKKIVSLEDLIKKIENLPTPKDFYKNILESKIKPGVIAEIKKASPSKGVIRKDFNPENIAICYEGLGASCISVLTDKKFFQGSYEILETVRKSTNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLIYLKKIADNLKMSVLVEVHNSYELERILKLKSFNLIGINNRDLKTFKTDLKTSKELMNTYADIFLKQNIIPISESGINCAEDLESLRSIGIMGVLIGETFMRETDIEQSFKKLFNSI
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: LGOX_STRDA
Sequence: MTETPRDNSATRARWQTCLKLARELLLVGPDDKDLKLSYLHTLIDTGRLGPTHHPRKKILVIGAGITGLVAGRLLKDAGYDVTIIEANESRVGGRIKTFRATKHHQPFDDAAQYAEAGAMRLPDFHPLVLALVDKLGLGRRQFYNVDVGPSTGSGPEVPVPPVTYTSFTGQTWTNGDDSPDFREPDKRGNSWIRANRVQVRRADYTASPERINEGFHLTGDEVRAPVVKMVDDALESVRDYYSDVVDGKRVNKPFDEWVEGWARVIRDFDGYSMGGFLRDHAGLSDEAIEAVGTLENTSSRLHLSFFHSFLSRSDINPTVRYWEIPGGSWRLPHALHEGLRDEVRLGHRMIRLEYHDPSRDADPEGTAVGPDGWGVTVETVAENDPQAPPRRWTADLAIVTIPFSALRFVEIVPSMSYKKRRAIVETHYDSATKVLLEFSHRWWEFTEDDWREELERIAPGVYEYYRLGPEAAGEPARMPTLAEADAGLLGAAVKDSGVTEEMRQIGSTMPLRGPALRPATHSFGGGSATDNPNRFMYYPSHRVEGSTGGVVLASYSWSDDAARWDSMRSAERYVYALRNLQALHGRRIEVFFTGRGATKSWARDPYAFGEAAIYTAHQMTSFHLDASRPEGPVHFAGEHTSLKHAWIEGALEVHTA
What is the function of this protein?
Catalyzes the oxidative deamination of L-glutamate to 2-ketoglutarate along with the production of ammonia and hydrogen peroxide (PubMed:27999974).  Exhibits strict specificity for L-glutamate, and shows only very weak activity with L-glutamine (PubMed:27999974).
What are the official names of this protein?
L-glutamate oxidase precursor, LGox.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. LGOX subfamily.
Protein: TARL_STAA8
Sequence: MVKSKIYIDKIYWERVQLFVEGHSENLDLEDSNFVLRNLTETRTMKANDVKIDGNQFVCRFNVAILDNGYYLPEDKYLLVNEQELDYIAQLNPDVINDAYQNLKPEQEEEYNELETQNGKINFLLQTYLKEFRKGGISKKTVYTVTPEISSDVNEFVLDVVVTTPEVKSIYIVRKYKELRKYFRKQSFNTRQFIFKAIFNTTKFFHLKKGNTVLFTSDSRPTMSGNFEYIYNEMLRQNLDKKYDIHTVFKANITDRRGIIDKFRLPYLLGKADYIFVDDFHPLIYTVRFRRSQEVIQVWHAVGAFKTVGFSRTGKKGGPFIDSLNHRSYTKAYVSSETDIPFYAEAFGIKEKNVVPTGVPRTDVLFDEAYATQIKQEMEDELPIIKGKKVILFAPTFRGSGHGTAHYPFFKIDFERLARYCEKNNAVVLFKMHPFVKNRLNIADKHKQYFVDVSDFREVNDILFITDLLISDYSSLIYEYAVFKKPMIFYAFDLEDYITTRDFYEPYESFVPGKIVQSFDALMDALDNEDYEGEKVIPFLDKHFKYQDGRSSERLVRNLFGS
What is the function of this protein?
Responsible for the polymerization of the main chain of the major teichoic acid by sequential transfer of ribitol phosphate units from CDP-ribitol to the second glycerol phosphate attached to the disaccharide linkage unit.  Synthesizes polymers of more than 40 ribitol phosphate units in length.
What are the official names of this protein?
Teichoic acid ribitol-phosphate polymerase TarL, Poly(ribitol phosphate) polymerase TarL, Ribitol-phosphate polymerase TarL, Tar polymerase TarL.
What is the protein family that this protein belongs to?
Belongs to the CDP-glycerol glycerophosphotransferase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: BIOB1_PARDP
Sequence: MIRTDWTMAEAWAIHALPFADLMHRAQTLHRAHFDPNAIETASLLSIKTGGCPEDCGYCSQSAHHDTGVKATKLMGTEEVLAAARRAKASGAQRFCMGAAWRSPKDRDMDKLCDMVRGVAELGLETCMTLGMLSPEQVARLKAAGLDFYNHNIDTSPEYYAQIASTRTMENRLDTVEQVRKGGIKVCCGGILGMGEAEEDRIAMLVTLATLPAHPDSVPVNLWNEIEGVPVQARAQAVDPFALVRIVALARILMPASVVRLSAGRTGMSDELQALCFLAGANSIFVGDQLLTTGNPAAWKDQDLLSRLGMHIAPAQARPRVAAE
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RIMM_FRATN
Sequence: MSQDFVEIAKIGATYKLDGELNLYPLANSIETLISYGDWYIQLPATNVWQQLKGESVLKRADKVYIKLANINDADTAKKYVNALIGVPKRALPQLAEDEVYFKDLIGCSVKNINNDSFGVVVDIIETGANEVLVCKEDNSEYLIPYVKQYIVSEDLNSKKIVVDWEYDY
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_PSYIN
Sequence: MSITIKLLVGLANPGPEYAQTRHNAGQWYVSQLASQENIQLKAEPKFYGLTGRIQFAGNDLRLLVPTTFMNLSGKAVAAMANFYRIKPEEILIAHDELDLLPGIAKFKLGGGHGGHNGLKDIIQKLGNDKNFYRLRIGIGHPGDKNRVSGYVLGKAPSSEQNLIDQSIDEAARCTHILGQDGLEKAMNRLHSFKAEK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_SACS2
Sequence: MSEEQKLVISSARRKTARATCYIYAGKGRVFVNNVPIELIPIEMVRLKIMEPLLLAGNDIRSKIDAKIITYGGGIMGQADAARMALARALVKFTGSKELEKIYRAYDRTMLAGDPRQTESEKWMRYSARRWRQKSYR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: URK_UREP2
Sequence: MNTKSPILILIAGASGSGKTTFANEIIARIPKNTTSVVICQDSYYISNSQLNKKERRLINYDHPSSFEWELMREQLSDIKKRKKIKVPIYDYKTEIRLDKTIDISDVDVIVLEGIYAIYDDVINQIADLKIFIETPKDECLIRRILRDVNERNRSFESVITQWRSTVSPMYDQFVEPSKKNANVSVLWNEHNRVALHLIHKWINNIH
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_NITHX
Sequence: MGSLSIWHWIVVIAVILLLFGRGKISDLMGDVAQGIKAFKKGMQDDEKTAEKPEPVKTIDHNAPAPGASRSDVGSKTTV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CDC42_CANAL
Sequence: MQTIKCVVVGDGAVGKTCLLISYTTSKFPADYVPTVFDNYAVTVMIGDEPFTLGLFDTAGQEDYDRLRPLSYPSTDVFLVCFSVISPASFENVKEKWFPEVHHHCPGVPIIIVGTQTDLRNDDVILQRLHRQKLSPITQEQGEKLAKELRAVKYVECSALTQRGLKTVFDEAIVAALEPPVIKKSKKCTIL
What is the function of this protein?
Involved in hyphal formation, virulence, morphogenesis.
What are the official names of this protein?
Cell division control protein 42 homolog.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: LZTS2_HUMAN
Sequence: MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI
What is the function of this protein?
Negative regulator of katanin-mediated microtubule severing and release from the centrosome.  Required for central spindle formation and the completion of cytokinesis.  May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon.  Negative regulator of the Wnt signaling pathway.  Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
What are the official names of this protein?
Leucine zipper putative tumor suppressor 2, hLZTS2, Protein LAPSER1.
What is the protein family that this protein belongs to?
Belongs to the LZTS2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
Protein: KITH_BHV16
Sequence: MAEPARALRVVRIYLDGAHGLGKTTTGRALAAASTAGEGVLFFPEPMAYWRTMFGTDALSGILAASARCAAASHGSARARRAGAPRRRGRGGPGCVLPGQVRGPVLNFARARVRAAAPPGPAPGGTVTLVFDRHPVAACLCYPFARYCLREINAEDLLMLAAAMPPEAPGANLVVCTLPPAEQQRRLAARARPGDRADAGFLVAVRNAYALLVNTCAFLRAGGDGATAGTRWSGRTQMHWPRSQTPVVMNAKCAGAGLRDTLFAALKCRELYPGGGTGLPAVHAWALDALAGRLAALEVFVLDVSAAPDACAAAVLDMRPAMQAACADGAAGATLATLARQFALEMAGEATAGPRGL
What is the function of this protein?
Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis.  The dTMP serves as a substrate for DNA polymerase during viral DNA replication.  Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae thymidine kinase family.
Protein: VP5_EUMPO
Sequence: MKTASFILSFVVLLIVIITWIGEVSAVSEPEPVAKATAHAAAVHVPPICSHRECRK
What are the official names of this protein?
Venom peptide 5, EpVP5, VP5.
What are the subcellular locations of this protein?
Secreted.
Protein: ALFP_ORYSJ
Sequence: MASATLLKSSFLPKKSEWGATRQAAAPKPVTVSMVVRAGAYDDELVKTAKTIASPGRGILAMDESNATCGKRLASIGLENTEANRQAYRTLLVTAPGLGQYISGAILFEETLYQSTVDGKKIVDILTEQKIVPGIKVDKGLVPLAGSNNESWCQGLDGLASREAAYYQQGARFAKWRTVVSIPNGPSELAVKEAAWGLARYAAISQDNGLVPIVEPEILLDGEHGIDRTFEVAQKVWAETFFYMAENNVMFEGILLKPSMVTPGAECKDRATPEQVSDYTLKLLHRRIPPAVPGIMFLSGGQSEVEATQNLNAMNQGPNPWHVSFSYARALQNTCLKTWGGQPENVKAAQDALLLRAKANSLAQLGKYTSDGEAAEAKEGMFVKNYVY
What is the function of this protein?
Plays a key role in glycolysis and gluconeogenesis.
What are the official names of this protein?
Fructose-bisphosphate aldolase, chloroplastic, Chloroplastic aldolase, AldP.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
What are the subcellular locations of this protein?
Plastid, chloroplast, plastoglobule.
Protein: CHLE_HUMAN
Sequence: MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
What is the function of this protein?
Esterase with broad substrate specificity.  Contributes to the inactivation of the neurotransmitter acetylcholine.  Can degrade neurotoxic organophosphate esters.
What are the official names of this protein?
Cholinesterase, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: PDXJ_CUPTR
Sequence: MIFHANPGVIDLGVNIDHVATLRNARGTVYPDPIRAALLAEQAGADLITLHLREDRRHIRDADVRALRPQLATRMNLECAITQEMLDIACEIRPQDVCLVPERREEVTTEGGLDVAGRFELVKAACAQLAGAGIRVSLFIDPDADQIAAAAACGAPVIELHTGRYADAHTPAEQAAEFRRIADGADAGQKHGLVVNAGHGLHYTNVQPIAALPGIKELNIGHAIVAHAVFTGWENAVREMKAIMVAARLGTQYPAASTPA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.