PharMolix/UniProtQA huggingface dataset:
Protein: TMTC4_HUMAN
Sequence: MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV
What is the function of this protein?
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.  The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions.  Also acts as O-mannosyl-transferase on other proteins such as PDIA3.
What are the official names of this protein?
Protein O-mannosyl-transferase TMTC4, Transmembrane and TPR repeat-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the TMTC family.
Protein: MESD_LEUME
Sequence: MVKTPMFHKKIDYISQVDERDCGVAALAMILAHYKTRLSLAKLRDLAKTDMEGTTALGIVKAANALDFETMPIQADLSLFDKKDLPYPFIAHVIKEGKYPHYYVVYGMKGDQLLIADPDNTVGKTKMTKAHFNEEWTGVSIFIAPNPTYKPTKEKKRSLTSFIPVITRQKLLVINIVIAALLVTLVSILGSYYLQGIIDTYIPNNMKNTLGIVSLGLIFAYVIQQLLSYARDYLLIVMGQRLSIDIILSYIKHIFELPMSFFATRRTGEIVSRFTDANAIIEALASTMLSVFLDLGILVIVGTVLVVQNSTLFLISLIAIPAYALVVWLFMRPFSKMNNDQMQAGSMLSSSIIEDINGVETIKALNSEATAYHKIDHEFVTYLEKSFVYAKTEAVQNAIKSLLQLSLNVVILWVGAQLVMTNKISVGQLITYNALLGFFTDPLQNIINLQTKLQQASVANNRLNEVYLVDSEFKDSHQMTEKITPNSSLVADHITYKYGFGAPAIDDVSLTITAGEKIALVGISGSGKSTLVKLLVNFFQPESGTISLGPTPLANLDKHELRGHINYLPQEPFIFSGSIMENLLLGAKPGTTQEDIIRAVEIAEIKDDIEKMSQGFGTELAESGNISGGQKQRIALARAILVDSPVLILDESTSNLDVLTEKKIIDNLMKLTEKTIIFVAHRLTISQRVDRILTMQSGKIIEDGTHDTLLKAGGFYASLFNH
What is the function of this protein?
Involved in the export process of the bacteriocin mesentericin-Y105.
What are the official names of this protein?
Mesentericin-Y105 transport/processing ATP-binding protein MesD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AKA7A_MOUSE
Sequence: MGQLCCFPFARDEGKICEKDRREPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSTKAEEGDRNGDGSDNNRK
What is the function of this protein?
Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel.  The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity).
What are the official names of this protein?
A-kinase anchor protein 7 isoform alpha, AKAP-7 isoform alpha, A-kinase anchor protein 18, AKAP-18, A-kinase anchor protein 9 kDa, AKAP 9, Protein kinase A-anchoring protein 7 isoform alpha, PRKA7 isoform alpha.
What are the subcellular locations of this protein?
Lateral cell membrane; Lipid-anchor.
Protein: CASC3_MOUSE
Sequence: MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSVGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEDYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSSPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNTAGTGRMSASRNYSRSGGFKDGRTSFRPVEVAGQHGGRSAETLKHEASYRSRRLEQTPVRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLASTATVPETTPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQSWSPSQPSFLQPRELRGVPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPGPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPNYPYAPGALPPPPPPHLYPNTQAPPQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPPEVVSRGSS
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome.  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Stimulates the ATPase and RNA-helicase activities of EIF4A3.  Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress.  Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons.  May play a role in mRNA transport.  Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.  Binds poly(G) and poly(U) RNA homomer.
What are the official names of this protein?
Protein CASC3, Cancer susceptibility candidate gene 3 protein homolog, Metastatic lymph node gene 51 protein homolog, MLN 51 homolog, Protein barentsz, Btz, mBtz.
What is the protein family that this protein belongs to?
Belongs to the CASC3 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Cytoplasm, Stress granule. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cell projection, dendrite. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (PubMed:12843282). Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (By similarity). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (Probable).
Protein: GPD_BPPM2
Sequence: MYIDATQYRNDDEFTQYAKGKVAQLRLMLNSKKSALQKDKELQQQAKAQESALAGEELRRRALSLATQNRMVTL
What are the official names of this protein?
Uncharacterized protein Gp-d.
Protein: NUOK1_GEOSL
Sequence: MVSLHSYLIVSAILFSIGTIGVLVRRNAIVIFMCVEMMLNAVNLTFIALSRHLGNIDGQIFVFFVMTVAAAEAAVGLALMIAFYKNRESIDVEDVKLMKL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K 1, NADH dehydrogenase I subunit K 1, NDH-1 subunit K 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNH2_KORVE
Sequence: MVRPKKKPVLGKDGKPLSAAAAKLRLLKRLKCTTKYEKLAADSGAKLIAGIDEVGRGALFGPVVAAAVILDPNYRIKGLRDSKLLPAETREILSKRIREHCIAWSIAAVDVARIDQLNIYWASNLAMKHAVRGLSCQPDHLLIDAMKLDLDCAQTPIIHGDALSASIAAASIIAKVHRDALIREWAPIFPEYDLASNKGYSAPKHIKALREFGPSPLHRQSFAPVWMASAPQEVLEFMLEETADTAVPPEVLED
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU5C_CRUWA
Sequence: MDHTYQYSWIIPFIPLPVPILLGVGLLLFPTATKNLRRMWTFLSIFLLSIVMIFSLYLSIQQIFLSCIHQNVWSWTINNEFSFEFGYFIDPLTSIMSILITTVGILVLIYSDNYMSHDQGYLRFFAYMGFFNTSMLGLVTSSNLIQVYFFWELVGMCSYLLIGFWFTRPIAANACQKAFVTNRLGDFGLLLGILGLYWITGSFEFQDLFEIFNNFILNNRVNLLFLTLCAFLLFVGPIAKSAQFPLHVWLPDAMEGPTPISALIHAATMVAAGIFLVARLLPLFIVIPSIMYIISLIGIITVLLGATLALAQKDIKRGLAYSTMSQLGYMMLALGMGSYRSALFHLITHAYSKALLFLGSGSIIHSMEAIVGYSPDKSQNMILMGGLTKHVPITKTAFLVGTLSLCGIPPLACFWSKDEILNDSLLFSPIFAIIACSTAGLTAFYMFRIYFLTFEGHLNTYFINYSGKKSSSLYSLSLWGKEEEKKLNRNFGLVPLLTMNNTKRASFFCNKTYKISNNVRNQIFITIENFGLNKKTFYYPHESDNTILFPMLVLLLFTLFIGAIGIPFNQEGIDFDILSKLFTPSINLLHKNSQNFVDWYEFLRNATFSVSIAVFGIFIAYCLYKPFYSSLLNLTLLNSFQKWNSKRIRWEKLINFVYKWSYNRGYVDAFFKTSLIESIRRLAKQTNFFDKRIIDGITNGVGITSFFVGEVTKYIGGSRISSYLFLYLSYVLIFLMILFFFYFEKF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic, NAD(P)H dehydrogenase subunit 5, NADH-plastoquinone oxidoreductase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SUCC_ERWT9
Sequence: MNLHEYQAKQLFARYGLPAPTGYACTTPREAEEAASKIGAGPWVVKCQVHAGGRGKAGGVKVVNSKEDIRAFAENWLGKRLVTYQTDASGQPVNQILVEAATDIDKELYLGAVVDRGTRRVVFMASTEGGVEIEKVAEETPHLIHKMALDPLTGPQPYQGRELAFKLGLTGKQVGQFTKIFMGLATLFLERDLALVEINPLVVTKQGDLVCLDGKLTADGNALFRQSDLREMRDPSQEDSREAHAAQWELNYVALEGNIGCMVNGAGLAMGTMDIVKLSGGQPANFLDVGGGATKERVTEAFKIILSDDAVKAVFVNIFGGIVRCDLIADGIIGAVAEVGVNVPVVVRLEGNNAELGARKLADSGLNIIAATSLSDAAQRVVAAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: MTNB_SCLS1
Sequence: MATQNPIQEVQESENSDHLIISQDPQHPANLIPELCSKFWHLGWVTGTGGGASIRNDNLVYLAPSGVQKELMKPEHIYVLDITAQVNPKQRIYLRSPPNLKPSQCTPLFMAAFTKRNAGCCIHTHSQWAVLITLLLESAPNTTMFEINNIEQIKAFGKGYTKTGNLGYHDTLRIPVIENTPHEEDLTEYLEEAMEKYPDTYAVLVRRHGVYVWGESVHKAKTQCESLDYLFQIAVEMKKLGLPWLSNVKPIA
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_CORGB
Sequence: MITRLSTLFLRTLREDPADAEVPSHKLLVRAGYIRRVAPGIYSWLPLGLRAVRNIEAVVREEMDAIGGQELLFPALLPREPYETTQRWTEYGDSLFRLKDRKGADYLLGPTHEEMFAATVKDLYNSYKDFPVTLYQIQTKYRDEERPRAGVLRGREFVMKDSYSFDMSDAGLDESYAKHRAAYQRIFDRLGLEYAICQATSGAMGGSASEEFLAVSENGEDTFVRSTSGNYAANVEAVVTQPGVERDIEGLPEAVTYETPVSETIDALVDWANSIDVQIEGREVTAADTLKCIVVKVREPGAEEAELTGILLPGDREVDMKRLEASLEPAEVELAVESDFADNPFLVKGYVGPVGLAKNGVKVLADPRVVTGTSWITGADEKERHVVGLVAGRDFTPDGFIEAAEIKEGDPAPAGEGTLTLARGIEIGHIFQLGRKYTEAFDVQILDENGKRAIPTMGSYGLGVTRLLAVLAEQRHDDAGLNWSVEVAPYQVHVVAANKDAAAIEAAERFAAELSAAGLDVLFDDRPKVSPGVKFKDAELLGMPFALILGRGYAEGKVELRVRGGEKSELDADQAVAQIVEMVAQARN
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_CUPNH
Sequence: MSSMRTHYCGLVTEQFSGQEVALTGWVQRRRDHGGVIFIDLRDREGLVQVVCDPDRPEMFKAAEEIRNEFCIRVTGKVRPRPAGTENANLTSGKIEVLCHELTVLNPSVTPPFQLDDDNLSETTRLTHRVLDLRRPQMQYNLRLRYKVAMEVRKFLDAQGFIDIETPMLGKSTPEGARDYLVPSRVNPGHFFALPQSPQIFKQMLMVSGFDRYYQITKCFRDEDLRADRQPEFTQIDCETSFLTEQEIRDLFEDMMRTVFKNAIDVDLDARFPVMEFREAMARFGSDKPDLRVKLEFTELTEVMKDVDFKVFSSPANSDNGRVVGLRVPGGGAISRGEIDAYTQFVGIYGAKGLAWIKVNEVAKGRDGLQSPIVKNLHDAAIAEILKRTGAQDGDIIFFGADKAKVVNDSIGALRLKIGHSDFGKANGLFEDTWKPLWVVDFPMFEYDEEDARWVAMHHPFTSPKDEHLEYLETDPGKCLAKAYDMVLNGWEMGGGSVRIFRSDIQSKVFRALNINDDEARAKFGYLLDALQYGAPPHGGLAFGLDRIVTMMAGADSIRDVIAFPKTQRAQDLLTQAPSSVDEKQLRELHIRLRATEPKPTA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F107A_MOUSE
Sequence: MYSEIQRERADIEGLMARPEYREWNSELIKPKKLLNPVKASRSHQELHRELLMNHKRGLGMDSKPELQRVLEHRRRNQLIKKKEEELEAKRMQCPFKQELLRRQQRLNQLENPPQRDEDHAPEFIKVRENLRRITTLTSEERAL
What is the function of this protein?
Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics (PubMed:21969592).  Mediates polymerization of globular actin to F-actin (PubMed:21969592).  Also binds to, stabilizes and bundles F-actin (PubMed:21969592).  Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (PubMed:21969592).  Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner.  Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner.  May play a role in tumor development (By similarity).
What are the official names of this protein?
Actin-associated protein FAM107A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Cell projection, ruffle membrane. Synapse. Note=Colocalizes with F-actin (PubMed:21969592). Colocalizes with F-actin and COMMD1 in the nucleus. Colocalizes with MAP1A along actin stress fibers and membrane ruffles (By similarity).
Protein: MTFR1_CHICK
Sequence: MIRWFKCFMRMIFEQVGLNMESVLWSSKPYGSSRSIVRKIGTNLSLIQCPRVQFQLTSQAAEGNHPHQFREDAVASFADVGWVAQEEGEVSTRLRSEVWSKTAQPLPGELHQPGHSLGRQDSVPNLLHEEPAPRSTVIANEEAMQKISALENELATLRAQIAKIVILQEQQNLTAAGLSPVASAAVPCVPPPPPPPPPPPLPPPALQQSMSAIELIRERKNRKTNSGPIPTENGPKKPEIPNMLEILKDMNSVKLRSVKKSSGDTKPKVADPTDPAALIAEALKKKFAYRYRRDSQSESDKVIPKSETNTKTEVVLFGPHMLKSTGKMKTLIEKS
What is the function of this protein?
May play a role in mitochondrial aerobic respiration.  May also regulate mitochondrial organization and fission.
What are the official names of this protein?
Mitochondrial fission regulator 1, Chondrocyte protein with a poly-proline region.
What is the protein family that this protein belongs to?
Belongs to the MTFR1 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=May be associated with the inner and the outer mitochondrial membrane.
Protein: RBP2_MEDTR
Sequence: MADGFWNRQQQHLPPPGGMLKRPRTEYDTAPSGVTSGNEVHNYIAQNNGHQMLNDTKILGSAYDRFLQSAGLTSFNSGEASVIGGVGFARGVGELPGHSLGDPSAMGHLSGVGGGPDLSRNGRDVNFGGQLPIDAVSRPGPETIPLPRDASSTLYVEGLPSDSTKREVAHIFRPFVGYREVRLVAKESKHRGGDPLILCFVDFANPACAATALSALQGYKVDEINPESSYLRLQFSRSPGRRSGGPGPRGKR
What is the function of this protein?
Probable RNA-binding protein.
What are the official names of this protein?
RNA-binding protein 2.
Protein: RL11_TERTT
Sequence: MAKKIEAYIKLQVKAGQANPSPPVGPALGQHGVNIMEFCKAFNAQTQGIEPGSPVPVVISVYSDRSFTFAMKTPPASFLLKRAAGIKSGSGRPNTEKVGKVNRAQLEEIATTKMPDLTAADMDAAVRTIAGSARAMGLDVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: COAD_PSEMY
Sequence: MNRVLYPGTFDPITKGHGDLVERAARLFDHVIIAVAASPKKNPLFPLEQRVELAREVTKHLPNVEVVGFSSLLAHFVKEQGANVFLRGLRAVSDFEYEFQLANMNRQLAPDVESLFLTPSEKYSFISSTLVREIAALGGDISKFVHPAVADALNARFQKN
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAT3A_XENLA
Sequence: MAVGYVDCHCHMTAEEFSQDTEEVIEESKENGIQALISVTEHGGEFEKLIYLSDRYPDYIMPCFGIHPIQSNGDGQRSVTIKDLEPVLAQFDKYKDSLVAIGEIGLDFTPWLAPTSEQREEQMKVFQMQLEMAKRMDLPVNVHSRSAGRQTVSFLKEQGAEKVLLHNFAGRPSAAQEGVQAGYFFSFPPAVIRNEQRKKLIKMIPLENICLETDSPSLGPKKEDRNVPSNIRLSCEYIASVKGLMPERVREVTTLNALRLFPKVSCKLQK
What is the function of this protein?
Putative deoxyribonuclease.
What are the official names of this protein?
Putative deoxyribonuclease tatdn3-A.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH10_PSELT
Sequence: MKVTPLGERLLIKPLKEEKKTEGGIVLPDSAKEKPMKAEVVAVGEKVENIDVKVGDRVIFSKYAGTEIKIDDVDYIIIDANDILAKIEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_STAA8
Sequence: MDHKSPLVSWNLFGFDIVFNLSSILMILVTAFLVFLLAIICTRNLKKRPTGKQNFVEWIFDFVRGIIEGNMAWKKGGQFHFLAVTLILYIFIANMLGLPFSIVTKDHTLWWKSPTADATVTLTLSTTIILLTHFYGIKMRGTKQYLKGYVQPFWPLAIINVFEEFTSTLTLGLRLYGNIFAGEILLTLLAGLFFNEPAWGWIISIPGLIVWQAFSIFVGTIQAYIFIMLSMVYMSHKVADEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RAC1_CAVPO
Sequence: AKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRTVFDEAIR
What is the function of this protein?
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states.  In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles.  Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages.  Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.  Stimulates PKN2 kinase activity.  In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts.  In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning.  Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity).  In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity).  In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (By similarity).  In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3 (By similarity).  In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity).
What are the official names of this protein?
Ras-related C3 botulinum toxin substrate 1, Sigma 1 component protein p22, p21-Rac1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Melanosome. Cell projection, lamellipodium. Cell projection, dendrite. Synapse. Nucleus. Note=Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Localizes to the lamellipodium in a SH3RF1- dependent manner. In macrophages, cytoplasmic location increases upon CSF1 stimulation (By similarity). Activation by GTP-binding promotes nuclear localization (By similarity).