PharMolix/UniProtQA huggingface dataset:
Protein: MET14_DROME
Sequence: MSDVLKSSQERSRKRRLLLAQTLGLSSVDDLKKALGNAEDINSSRQLNSGGQREEEDGGASSSKKTPNEIIYRDSSTFLKGTQSSNPHNDYCQHFVDTGQRPQNFIRDVGLADRFEEYPKLRELIKLKDKLIQDTASAPMYLKADLKSLDVKTLGAKFDVILIEPPLEEYARAAPSVATVGGAPRVFWNWDDILNLDVGEIAAHRSFVFLWCGSSEGLDMGRNCLKKWGFRRCEDICWIRTNINKPGHSKQLEPKAVFQRTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIISEEEEFGSFEKPIEIFHIIEHFCLGRRRLHLFGRDSSIRPGWLTVGPELTNSNFNSELYQTYFAEAPATGCTSRIELLRPKSPPPNSKVLRGRGRGFPRGRGRPR
What is the function of this protein?
Non-catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:28675155).  In the heterodimer formed with Ime4/Mettl3, Mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (By similarity).  Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:27919077, PubMed:28675155).  M6A methylation is also required for neuronal functions (PubMed:27919077).
What are the official names of this protein?
N6-adenosine-methyltransferase non-catalytic subunit, Karyogamy protein 4, Methyltransferase-like protein 14, dMettl14.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPXS2_DICDI
Sequence: MKFRDYLKDNKVSHWRDKYIDYEYLKNLIDNEYINAEILNSAIIDLPLSPEEQNNINKNNNNNNNNNNNNNNNNNNNNNINNNNNNNNTLKDGEQTNSNNISIPNQMAPQESSGEDEDDENENGNGVVGDEDGGDDDEIEMDELVIDDNGEIINITATAGSRVKVKKGINKGVKRLKKIAKNTNNRLSRMVSRSPKNKGLGSSSEIEGDEFQLDGGGISSQIEMVASNNITGATVFVPQETFQDGFIDQVNKVDIFFVDRYRKTKFKCVDLVGMIPFLSDNEQLRTIRNIDYVKQGFHDNYHYLESLESYKNLNLDGFYKILDKYEKINPRIAKECRKYLENTRLTSTNSPVRELSRRIKQIYARYFTGNDIKLANNQIRTNKQVNQFQNYIIGFLIGASAILIAQVIFKFYYYFPDVADSPKNSPMAWLLFRISSLPIILGTLFALMTKLWEKAGINYVFIFELKPDIKRSSSRYLMYGMIFVTMWLVVFNVYVDSISNKTGSPETSRYLLLIPLLFILGSIFFLILPFKVLAHRTRFWVLHKMSKVVQAPFVPVRFPDFFMSVQLLCLGEFLFNMQQIVCMFKFNDPLYSPSGVCFKHKAVIFPILSVLPFYWRVMQCVRRFWETGQFFPHITSAIRSTFSIVTNILLWVANNYGNKEWSWIKILWFIINVVGTVYKLYADFTVDWGLFLNYKTNKQWPLREKMVFKRKWVYYVAMSFDTFFRFVWLIVFSIRQGTSYKLDHPLFLFWFSLSEIAWAAQFIFFRVESEHVQCADTYSHFKDIPLPFSQDYKNYMEEKKSRYDEKKPHHHHHHDNNNNETKDGSGGTHHRRNLSNGHHPYDDDDDDESIDSDADSKDLNLESNSEFVDDEGYNQRKNSIISSIKKIASTQELNSMNRISSHPDLYSTMQRFAGHVPDSNSSMPRMYSHPDFNHPIPRVLTSHVEVNPSTLRTVPQHRLNNIPNQRIISHADINPQHLRVGSPRVEFNSTVQQRSPHGEIQSSMIRNHSRADLNSSMQRIQSHPELNSSNRNQVDPNSPMNRLITRADLNKSR
What are the official names of this protein?
SPX and EXS domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the SYG1 (TC 2.A.94) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IBB1_PHAAN
Sequence: SGHHDETTDEPSESSKPCCDQCSCTKSMPPKCRCSDIRLNSCHSACKSCACTYSIPAKCFCTDINDFCYEPCKSSRDDDWDN
What is the function of this protein?
Trypsin and chymotrypsin are inhibited simultaneously.  There are two separate reactive sites for trypsin and chymotrypsin but they do not inhibit simultaneously.
What are the official names of this protein?
Bowman-Birk type proteinase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the Bowman-Birk serine protease inhibitor family.
Protein: RL34_CERS4
Sequence: MKRTFQPSNLVRARRHGFRARMATKGGRLVLNARRAKGRKKLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: GSHB_MOUSE
Sequence: MATSWGSILQDEKQLEELAKQAIDRALAEGVLLRSAQHPSSSDVVTYAPFTLFPSPVPSALLEQAYAVQMDFNILVDAVSQNPAFLEQTLSSTIKKDDYTARLFDIYKQVLKEGIAQTVFLGLNRSDYMFQCGADGSKALKQIEINTISASFGGLASRTPAVHRHVLNVLNKTKEASKILSNNPSKGLALGIAKAWELYGSANAVVLLIAQEKERNIFDQRAVENELLDRKIHVIRGRFEDVSERGSLDQNRRLFMDDQEVAVVYFRDGYMPSQYNSQNWEARLMLERSRAAKCPDIAIQLAGTKKVQQELSRVGLLEALLPGQPEAVARLRATFAGLYSLDMGEEGDQAIAEALAAPSHFVLKPQREGGGNNLYGEEMVQALEQLKDSEERASYILMEKIEPEPFRNCLLRPGSPAQVVQCISELGIFGVYVRQGTTLVMNKHVGHLLRTKAVEHADGGVAAGVAVLDNPYPV
What is the function of this protein?
Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner.  Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes.  Participates in ophthalmate biosynthesis in hepatocytes (PubMed:16608839).
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic GSH synthase family.
Protein: C1T9A_HUMAN
Sequence: MRIWWLLLAIEICTGNINSQDTCRQGHPGIPGNPGHNGLPGRDGRDGAKGDKGDAGEPGRPGSPGKDGTSGEKGERGADGKVEAKGIKGDQGSRGSPGKHGPKGLAGPMGEKGLRGETGPQGQKGNKGDVGPTGPEGPRGNIGPLGPTGLPGPMGPIGKPGPKGEAGPTGPQGEPGVRGIRGWKGDRGEKGKIGETLVLPKSAFTVGLTVLSKFPSSDMPIKFDKILYNEFNHYDTAAGKFTCHIAGVYYFTYHITVFSRNVQVSLVKNGVKILHTKDAYMSSEDQASGGIVLQLKLGDEVWLQVTGGERFNGLFADEDDDTTFTGFLLFSSP
What is the function of this protein?
Probable adipokine.  Activates AMPK, AKT, and p44/42 MAPK signaling pathways.
What are the official names of this protein?
Complement C1q and tumor necrosis factor-related protein 9A, Complement C1q and tumor necrosis factor-related protein 9.
What are the subcellular locations of this protein?
Secreted.
Protein: PDCD7_HUMAN
Sequence: MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESKLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGNFVPQGWVLPPLPSNDIWATAVKLH
What is the function of this protein?
Promotes apoptosis when overexpressed.
What are the official names of this protein?
Programmed cell death protein 7, ES18, hES18.
What are the subcellular locations of this protein?
Nucleus.
Protein: ODO1_STAA2
Sequence: MTNERKEVSEAPVNFGANLGLMLDLYDDFLQDPSSVPEDLQVLFSTIKNDDSIVPALKSTSSQNSDGTIKRVMRLIDNIRQYGHLKADIYPVNPPKRKHVPKLEIEDFDLDQQTLEGISAGIVSDHFADIYDNAYEAILRMEKRYKGPIAFEYTHINNNTERGWLKRRIETPYKVTLNNNEKRALFKQLAYVEGFEKYLHKNFVGAKRFSIEGVDALVPMLQRTITIAAKEGIKNIQIGMAHRGRLNVLTHVLEKPYEMMISEFMHTDPMKFLPEDGSLQLTAGWTGDVKYHLGGIKTTDSYGTMQRIALANNPSHLEIVAPVVEGRTRAAQDDTQRAGAPTTDHHKAMPIIIHGDAAYPGQGINFETMNLGNLKGYSTGGSLHIITNNRIGFTTEPIDARSTTYSTDVAKGYDVPIFHVNADDVEATIEAIDIAMEFRKEFHKDVVIDLVGYRRFGHNEMDEPSITNPVPYQNIRKHDSVEYVFGKKLVNEGVISEDEMHSFIEQVQKELRQAHDKINKADKMDNPDMEKPAELALPLQADEQSFTFDHLKEINDALLTYPDGFNILKKLNKVLEKRHEPFNKEDGLVDWAQAEQLAFATILQDGTPIRLTGQDSERGTFSHRHAVLHDEQTGETYTPLHHVPDQKATFDIHNSPLSEAAVVGFEYGYNVENKKSFNIWEAQYGDFANMSQMIFDNFLFSSRSKWGERSGLTLFLPHAYEGQGPEHSSARLERFLQLAAENNCTVVNLSSSSNYFHLLRAQAASLDSEQMRPLVVMSPKSLLRNKTVAKPIDEFTSGGFEPILTESYQADKVTKVILATGKMFIDLKEALAKNPDESVLLVAIERLYPFPEEEIEALLAQLPNLEEVSWVQEEPKNQGAWLYVYPYVKVLVADKYDLSYHGRIQRAAPAEGDGEIHKLVQNKIIENALKNN
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
Protein: Y4OE_SINFN
Sequence: MTMMKAIWPEPSDPESMMEAAIDLFGDEAATAVAHCGLEAWTDGRADDFAFWVDIFRSLTGMPSAGAGN
What are the official names of this protein?
Uncharacterized protein y4oE.
Protein: RUVB_MARMM
Sequence: MTEEFDQTEAERLVDRDMQPGDGRDRALRPLSFSDFVGQKAAIANLKVFVDAARRREEALDHVLLSGPPGLGKTTLAQIVAREMGVGFRATSGPVIAKAGDLAAILTNLEPRDVLFIDEIHRLAPAVEEILYPAMEDFCLDLVIGEGPSARTVRIELPPFTLVGATTRAGLLATPLRDRFGVPVRLEFYDEAELGFIVTRAADKLGIGATPDGAREIARRARGTPRVAGRLLRRVRDFAEAEDADHISEAVADRALKRLEVDAIGLDSLDRRYLRALTESFGGGPVGVETLAAALAEARDALEDVVEPFLIQQGFIQRTPRGRLATGRAWEHLGLVPPQSGQPAAPGGLFGK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SIGA_LISMO
Sequence: MSDKTKNTKPVAELSVEQVKEALIEEGKKKGILTYAKIAARLAPFTLDSDQMDEYLEHVGEAGIEVSDDADDEDPDETELVKEETESFDLTDMSVPPGVKINDPVRMYLKEIGRVDLLTADEEIALAKRIEAGDIEAKGRLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNMGLMKAVEKFDFNKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVQRSLLQDLGRDPSPEEIGEEMDLPTEKVREILKIAQEPVSLETPIGEEDDSHLGDFIEDQDATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEEVGRVFGVTRERIRQIEAKALRKLRHPSRSKQLKDFLE
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA, Sigma-43.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F131B_BOVIN
Sequence: MDSTSSLHGSSLHRPSTEQTRTDFSWDGINLSMEDTTSILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKTPAIQPQHSHEAVRRDTDAYSDLSDGEKEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQETLGCNYSDNYQELMESQDALAQAPMDGWPHSYVSQGMYCLGSSDAWEASDQSLIASPATGSYLGPAFGDSQPSLHEMGPSQPASGYSAQEPSSLLGGDTDWAPGVGGVDLAGGPAEEEKRKKMRGAGTWSPSPHARTPRCPPLSAGRCLTSHPQACSPLMRRKARPTTSFLPLLTQPSTPA
What are the official names of this protein?
Protein FAM131B.
What is the protein family that this protein belongs to?
Belongs to the FAM131 family.
Protein: SYT_ACTPJ
Sequence: MPIITLPDGSQRQFDNPVSVMEVAQSIGAGLAKATIAGRVNGERRDACDIISEDSSLEIITAKDEDGLEIIRHSCAHLLGHAIKQLFPDVKMAIGPTIDNGFYYDVDLDRSLTQEDLDAIEKRMLELAKTNYDVVKKRVSWQEARDTFEKRGEPYKMAILDENIERTATPALYHHEEYIDMCRGPHVPNMRFCHHFKLQKVAGAYWRGDSKNKMLQRIYGTAWADKKQLAEYLTRLEEAAKRDHRRIGKALDLYHMQEEAPGLVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMDRVLWERTGHWQNYADLMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTSCIRMVYDIYSTFGFSNIQVKLSTRPENRIGDDAMWDRAEDGLAKALTANGLSYEIQEGEGAFYGPKIEFALRDCLDREWQCGTIQLDFALPGRLDASYVAEDNGRRTPVMIHRAILGSIERFIGIITEEYAGFFPTWLAPTQAVVMNITDSQADYVQKVTKALSDAGIRAKSDLRNEKVGFKVREHTLRRVPYMLVCGDKEIEAGKVSVRTRKGADLGTFTIDEFVEILKNQVKARGLKLLGEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_NEIMF
Sequence: MPTINQLVRKGRQKPVYVNKVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCKVRLTNGFEVISYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGSLDTAGVKDRKQARSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: HLDE_ESCF3
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKEPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: LGR4_XENTR
Sequence: MGCPGWPLALFALLLASCSGGPSGVSSPAPCPAPCACDLDGGADCSGKGLVTVPDGLSVFTHSLDLSMNNITKLPEGAFKGFPYLEELRLAGNDLSIIHPMALSGLKELKVLTLQNNQLKTVPSESLKGLVSLQSLRLDANHIVTVPEDSFEGLVQLRHLWLDDNSLTEVPIRPLSNLPSLQALTLALNKISHIPDYAFSNLSSLVVLHLHNNKIRTLGPHCFHGLDNLEALDLNYNNLIDFPDSIRSLPNLKELGFHSNSITIIPDGAFVKNPLLRTIHLYDNPLSFVGNSAFQNLSDLHFLIIRGASNVQWFPNLTGTNNLESLTLTGTKIRSIPIKFCQEQKMLRTLDLSYNEISALVGFEGCSSLEEVYLQNNQIQEVQNETFQGLAALRMLDLSRNRIHTIHKEAFVTLKALTNLDLSFNDLTAFPTAGLHGLNQLKLTGNPNFKETLTAKDLIKLSSVSVPYAYQCCAFSACNSYMTTTVEEDRLRAQRLLLDHDRAAMDPDYMGTEDDKEHVQALIQCNPATGPFKPCEYLLGSWMIRLTVWFIFLLALIFNVIVIVTMFASCSQLTSSKLFIGLIAVSNLFMGVYTGTLTVLDTISWGQFAEFGIWWETGNGCKVAGFLAIFSSESAIFFLMLAAIERSLSAKDIIKKEKHQHLRKFQVASLLAVLLAAAAGCLPLFHIGEFSSSPLCLPFPTGETPSLGFTVTLVLLNSLAFLIMVITYTKLYCTIEKEDLSENAESSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAIYISPEIMKSVTLIFLPLPACLNPVLYVFFNPKFKEDWKLLRWRLTKRSGSVAVATNSQRGCVTQDFYYDFGMYSHLQGGNFAVCDYCESVLLKNPPPCKHLIKSHSCPTLAVVPCQRPDNYWSEFGTQSAHSDCADEEDSFVSDSSDQVQVCGRACFYQSRGLPLVRYAYNIPRMKD
What is the function of this protein?
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs.  Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal.  Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.  May play a role in regulating the circadian rhythms of plasma lipids (By similarity).  Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity).
What are the official names of this protein?
Leucine-rich repeat-containing G-protein coupled receptor 4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GNAT1_BOVIN
Sequence: MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKKAHLSICFPDYNGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
What is the function of this protein?
Functions as signal transducer for the rod photoreceptor RHO (PubMed:21285355, PubMed:23303210, PubMed:28655769, PubMed:8259210).  Required for normal RHO-mediated light perception by the retina (By similarity).  Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO.  The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21285355, PubMed:28655769, PubMed:8259210, PubMed:8208289, PubMed:7969474).  Activated RHO promotes GDP release and GTP binding (PubMed:21285355, PubMed:28655769).  Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (PubMed:21285355).
What are the official names of this protein?
Guanine nucleotide-binding protein G(t) subunit alpha-1, Transducin alpha-1 chain.
What are the subcellular locations of this protein?
Cell projection, cilium, photoreceptor outer segment. Membrane; Peripheral membrane protein. Photoreceptor inner segment. Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark- adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light.
Protein: HYPB_AZOCH
Sequence: MCTVCGCAEGETRIEGEHHHHGYDHGHHHHDHAFVRRPAPAEAAPLVVEGLNLHFGQGPARAHAPGLSQSRMVQIEQDILGKNDRYAAENRARFEALSLFVLNLVSSPGSGKTTLLTKTIELLGRHRPLAVIEGDQQTDHDAARIRATGVPAVQVNTGKGCHLDAHMVGRAFEQLEGLDGGLLFIENVGNLVCPAAFDLGEAHKVAILSVTEGEDKPLKYPDMFHAADLMLLNKTDLLPHLDFDVEACIAYARRVNPDIKVIRVSARSGEGMGEWLAWIERQRGARLRARIDALRAQAQALEALL
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.  Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion.
What are the official names of this protein?
Hydrogenase maturation factor HypB.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.
Protein: TRUA_HELPS
Sequence: MRCFKATIAYDGAYFLGYAKQPNKLGVQDKIESALNALGIKSVVVAAGRTDKGVHANNQVLSFYAQKHWNAAKLFYYLAPKLAPHVVLKKLEEKNFHARFDAQKRAYRYLLTKNLKTPFLAPYIACGDYGSLDALNTALKQFTGKHDFSMFKKEGGATTNPKRAIFNAFAYKTFIIGHECVVFKIIGDAFLRSSVRLIVQACVQYSLEKITLAEIQAQIHNIKATIRTPIMANGLYLHRVYY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GLDN_MOUSE
Sequence: MTRAAERGQGATGWGLRGALVAIALLSALNAAGTVFVLCQWRGLSAALRALEAQRGREQREDSALRAFLAELSRAPGRVPEPSQDPMSAARNKRSHNGEPASHIRAESQDMMMMMTYSMVPIRVMIDLCNSTQGICLTGPPGPPGPPGAGGLPGHNGSDGQPGLQGPKGEKGAIGKRGKMGLPGATGNPGEKGEKGDAGELGLPGNEGPPGQKGDKGDKGDVSNDVLLTGAKGDQGPPGPPGPPGPPGPPGSRRSKGPRPPNVFNSQCPGETCVIPNDDTLVGRADEKANERHSPQTESMITSIGNPAQVLKVRETFGTWMRESANKSDDRIWVTEHFSGIMVKEFKDLPALLNSSFTLLHLPHYFHGCGHAVYNNSLYYHKGGSNTIVRFEFGKETPQTLKLENALYFDRKYLFANSKTYFNIAVDEKGIWIIYASSVDGSSILVAQLDERTFSVTQHINTTYPKSKAGNAFIARGILYVTDTKDTRVTFAFDLLGGKQINANFDFRMSQSVLAMLSYNMRDQHLYSWEDGHLMLYPVQFLSAASSQR
What is the function of this protein?
Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons.  Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:20188654).  Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons.  During development, nodes of Ranvier are formed by the fusion of two heminodes.  Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters (PubMed:20188654).  Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (PubMed:24719088).
What are the official names of this protein?
Gliomedin, Cancer-related gene liver 2 protein, CRG-L2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell projection, axon. Note=Localizes to the nodes of Ranvier (PubMed:17293346, PubMed:20188654). Detected at immature heminodes (By similarity). SUBCELLULAR LOCATION: [Gliomedin shedded ectodomain]: Secreted. Secreted, extracellular space, extracellular matrix. Note=Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:17293346). The gliomedin shedded ectodomain localizes to the nodes of Ranvier (By similarity).
Protein: KPRS_STAAM
Sequence: MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSYPVNLHLMELLIMIDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVANLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAKHFKDDPNINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLAAQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVAGLIAQAIIRVYERESVSVLFD
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_HAEIE
Sequence: MIGRLQGILLEKQPPEILLNVQGVGYELLLPMTSFYDLPEIGQETTLFTHLVVREDAHLLFGFAQKTDRTLFRELIKTNGVGPKLALAILSAMSVEQFAYAIEREELSKLTKIPGVGKKTAERLLVELKGKFKGVKQSDFFVESTHIPLSPSIESHSESSSDEAISALIALGYKPVEAEKMVKRVAKPELTSEQVIREALKAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.