PharMolix/UniProtQA huggingface dataset:
Protein: AB42G_ORYSJ
Sequence: MEKVWESGRRMSRSIGRGMGMEAWGVDEAFMPQNSGGGGGSRGRRRSGRGGTADDDEEALRWAAIERLPTYSRMRTAILSSAEEEAAAAAAGAGKQQYKEVDVRRLGVGERQEFIERVFRVAEEDNQRFLQKLRNRIDRVGIELPTVEVRFEELMVQARCHVGSRALPTLLNTARNIAEAALGLVGVRPGRQATLTILRGVSGAVRPSRMTLLLGPPSSGKTTLLLALAGKLDPSLRRGGEVTYNGFELEEFVAQKTAAYISQTDVHVGEMTVKETLDFSARCQGVGTKYDLLTELARREKEAGIRPEPEVDLFMKATSMEGVESSLQTDYTLRILGLDICADTIVGDQMQRGISGGQKKRVTTGEMIVGPTKVLFMDEISTGLDSSTTFQIVKCLQQIVHLGEATILMSLLQPAPETFELFDDIILLSEGQIVYQGPREYVLEFFESCGFRCPERKGTADFLQEVTSKKDQEQYWADKHRPYRYISVSEFAQRFKRFHVGLQLENHLSVPFDKTRSHQAALVFSKQSVSTTELLKASFAKEWLLIKRNSFVYIFKTIQLIIVALVASTVFLRTQMHTRNLDDGFVYIGALLFSLIVNMFNGFAELSLTITRLPVFFKHRDLLFYPAWIFTLPNVILRIPFSIIESIVWVIVTYYTIGFAPEADRFFKQLLLVFLIQQMAGGLFRATAGLCRSMIIAQTGGALALLIFFVLGGFLLPKAFIPKWWIWGYWVSPLMYGYNALAVNEFYSPRWMNKFVLDNNGVPKRLGIALMEGANIFTDKNWFWIGAAGLLGFTMFFNVLFTLSLVYLNPLGKPQAVISEETAKEAEGNGDARHTVRNGSTKSNGGNHKEMREMRLSARLSNSSSNGVSRLMSIGSNEAGPRRGMVLPFTPLSMSFDDVNYYVDMPAEMKQQGVVDDRLQLLRDVTGSFRPAVLTALMGVSGAGKTTLMDVLAGRKTGGYIEGDMRISGYPKNQETFARISGYCEQNDIHSPQVTVRESLIYSAFLRLPEKIGDQEITDDIKIQFVDEVMELVELDNLKDALVGLPGITGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVVCTIHQPSIDIFEAFDELLLLKRGGQVIYSGQLGRNSQKMIEYFEAIPGVPKIKDKYNPATWMLEVSSVAAEVRLNMDFAEYYKTSDLYKQNKVLVNQLSQPEPGTSDLHFPTKYSQSTIGQFRACLWKQWLTYWRSPDYNLVRFSFTLFTALLLGTIFWKIGTKMGNANSLRMVIGAMYTAVMFIGINNCATVQPIVSIERTVFYRERAAGMYSAMPYAIAQVVMEIPYVFVQTAYYTLIVYAMMSFQWTAAKFFWFFFVSYFSFLYFTYYGMMTVAISPNHEVAAIFAAAFYSLFNLFSGFFIPRPRIPKWWIWYYWLCPLAWTVYGLIVTQYGDLEQIISVPGQSNQTISYYVTHHFGYHRKFMPVVAPVLVLFAVFFAFMYAICIKKLNFQHR
What is the function of this protein?
May be a general defense protein.
What are the official names of this protein?
ABC transporter G family member 42, OsABCG42, Pleiotropic drug resistance protein 12, OsPDR12.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SEC23_YEAST
Sequence: MDFETNEDINGVRFTWNVFPSTRSDANSNVVPVGCLYTPLKEYDELNVAPYNPVVCSGPHCKSILNPYCVIDPRNSSWSCPICNSRNHLPPQYTNLSQENMPLELQSTTIEYITNKPVTVPPIFFFVVDLTSETENLDSLKESIITSLSLLPPNALIGLITYGNVVQLHDLSSETIDRCNVFRGDREYQLEALTEMLTGQKPTGPGGAASHLPNAMNKVTPFSLNRFFLPLEQVEFKLNQLLENLSPDQWSVPAGHRPLRATGSALNIASLLLQGCYKNIPARIILFASGPGTVAPGLIVNSELKDPLRSHHDIDSDHAQHYKKACKFYNQIAQRVAANGHTVDIFAGCYDQIGMSEMKQLTDSTGGVLLLTDAFSTAIFKQSYLRLFAKDEEGYLKMAFNGNMAVKTSKDLKVQGLIGHASAVKKTDANNISESEIGIGATSTWKMASLSPYHSYAIFFEIANTAANSNPMMSAPGSADRPHLAYTQFITTYQHSSGTNRIRVTTVANQLLPFGTPAIAASFDQEAAAVLMARIAVHKAETDDGADVIRWLDRTLIKLCQKYADYNKDDPQSFRLAPNFSLYPQFTYYLRRSQFLSVFNNSPDETAFYRHIFTREDTTNSLIMIQPTLTSFSMEDDPQPVLLDSISVKPNTILLLDTFFFILIYHGEQIAQWRKAGYQDDPQYADFKALLEEPKLEAAELLVDRFPLPRFIDTEAGGSQARFLLSKLNPSDNYQDMARGGSTIVLTDDVSLQNFMTHLQQVAVSGQA
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.  SEC23 interacts with BET3 in order to target TRAPPI complex to COPII involved in internalization of plasma membrane proteins like the maltose transporter.
What are the official names of this protein?
Protein transport protein SEC23.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: H2B2_CAEEL
Sequence: MAPPKPSAKGAKKAAKTVTKPKDGKKRRHARKESYSVYIYRVLKQVHPDTGVSSKAMSIMNSFVNDVFERIAAEASRLAHYNKRSTISSREIQTAVRLILPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B 2.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MNMA1_CLOB1
Sequence: MKKKVLVGMSGGVDSSVAAYLLKEQGYEVIGVTMQIWQDDEEFIEKEGGCCSLSAVADARRVANKIGIPFYVMNFKDAFKRNVIDYFVDEYMEGRTPNPCIACNKFIKFSSFLDKAMAIGIDYVATGHYAIIEKHNDRYIIKKSEDDKKDQTYALYNLTQFQLERTLMPCGQYKKSKIREIAKEIGLRVHNKKDSEEICFIPDNDHGRYIKNRFPNKVREGNFVDKQGNILGTHKGIVYYTIGQRKGLGIAFGKPMYVVDINPFRNEVVLGDLEDLLNTKLIAKDTNYIPFDTLKEPMEVEAKIRYSQTPSKAIITPIEDGRVRVNFHEKQRAITKGQSVVFYKDDLLIGGGIIEK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA 1.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPPK_CAMJE
Sequence: MLKIQGVKHFEKSRFFPFFSQNIRSFKYLALIGLGSNIEPEKKRFDMLFRVMMDDKRFKILSTSPMLINEAFGFKEQKDFTNAVMLIQTNLHARALLKVLLYYEVKFKRKRTFKNAPRTLDLDLLYFSQKVKRDKWCEVPHKGAKERVSVILPLGMI
What is the function of this protein?
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
What are the official names of this protein?
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK.
What is the protein family that this protein belongs to?
Belongs to the HPPK family.
Protein: MRAZ_MYCBT
Sequence: MFLGTYTPKLDDKGRLTLPAKFRDALAGGLMVTKSQDHSLAVYPRAAFEQLARRASKAPRSNPEARAFLRNLAAGTDEQHPDSQGRITLSADHRRYASLSKDCVVIGAVDYLEIWDAQAWQNYQQIHEENFSAASDEALGDIF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RS17E_PYRFU
Sequence: MGKIRQGFIKRVARELVNKYPNEFTTDFEHNKKKVQELTNVTSKKIRNRIAGYVTKLVRMKMEGKIL
What are the official names of this protein?
30S ribosomal protein S17e, Small ribosomal subunit protein eS17.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: LEPA_KOCRD
Sequence: MSPLAVNPPAPASTDPSVIRNFCIIAHIDHGKSTLADRMLQATGVVTPRQMKAQYLDRMDIERERGITIKSQAVRMPWNVDGTDYALNMIDTPGHVDFTYEVSRSLAACEATILLVDAAQGIEAQTLANLYLAIENDLTIIPVLNKIDLPAAQPEKYAAELANLIGVEPEEVLKVSGKTGEGVEELLERIVRDVPPPQGVKDAPSRAMIFDSVYDTYRGVVTYVRVVDGTLVPRERIQMMSTGATHELLEIGVISPEPIPSKGLSVGEVGYLITGVKDVRQSRVGDTVTNQQKPAQESLGGYEDPKPMVFSGLFPVEGSDYPVLRDALEKLQLNDAALVYEPETSAALGFGFRCGFLGLLHLEITRDRLEREFNLDLISTAPSVSYNVTLEDHSEVEVTNPSEFPEGRILEIREPMVSATILVPSEFIGAVMELSQSKRGEMKGMDYLSEDRVELRYRLPLAEIVFDFFDQLKSKTRGYASLDWKADGEQAADLVKVDILLQGEQVDAFSAITHKDKAYSYGVLMTGKLQKLIPRQQYEVPIQAAIGSRIIARENIRAIRKDVLSKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFVAALSSDEDNGKDKKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL2_BURCH
Sequence: MAIVKVKPTSPGRRAMVKVVNKNLHQGKPFAALLDSQSSTAGRNNNGRITTRHKGGGHKQHYRIVDFRRTKDGIPAKVERLEYDPNRSANIALVLYADGERRYIIAPKGLTVGQQLMSGSEAPIRAGNTLPIRNIPVGTTIHCIEMLPGKGAQMARSAGTSAMLLAREGVYAQVRLRSGEIRRVHIECRATVGEVGNEEHSLRQIGKAGANRWRGIRPTVRGVAMNPVDHPHGGGEGKTAAGRDPVSPWGTPAKGYRTRSNKRTTTMIVQRRHKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: 5NT3B_MOUSE
Sequence: MAEEVSSLMKATVLMRQPGRVQEIVGALRRGGGDRLQVISDFDMTLSRFAYNGQRCPSSHNILDNSKIISEDCRKELTELFHHYYPIEIDPHRTIKEKLPHMVQWWSKAHSLLCQQRIQKVQIAQVVGESTAMLREGYKTFFDTLYQNNIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFSEDGFLKGFKGQLIHTYNKNSSVCENSSYFQQLQNKTNIILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDSYDIVLEKDETLDVVNGLLRHILYQGDCVELQGS
What is the function of this protein?
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate.  The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids.  Also has weak activity for CMP.  UMP and purine nucleotides are poor substrates (By similarity).
What are the official names of this protein?
7-methylguanosine phosphate-specific 5'-nucleotidase, 7-methylguanosine nucleotidase, Cytosolic 5'-nucleotidase 3B, Cytosolic 5'-nucleotidase III-like protein, cN-III-like protein, N(7)-methylguanylate 5'-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the pyrimidine 5'-nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS27A_NEUCR
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDSDGKIERLRRECPNETCGAGVFMAAMQDRQYCGRCHLTYVFEKSS
What is the function of this protein?
Ribosomal protein S27a is a component of the 40S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-40S ribosomal protein S27a.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus.
Protein: CALRL_HUMAN
Sequence: MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
What is the function of this protein?
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity).  Receptor for adrenomedullin together with RAMP2 (PubMed:22102369, PubMed:30115739).  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:22102369, PubMed:30115739).
What are the official names of this protein?
Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NU2M_MYTED
Sequence: MVVCGETMKLVSLGVMLIGTILSVSSEELVGVWLGLELNLYGFLVIMNPDGHYSPEPCVKYFVVQSTGSILMLVGFVSLMEQHVVSGLVMSTAXTVLKSGVFPLHSWVPSVIKNSSWLASGLMLTWQKVAPLVFLSMILPSKSLWVVIVSMAGIGAVGGLNQNSVRVMSAYSSFVHTSWMLLGLTWSSVVFVGYFAVYSLSVGLFFYGCSLMNKMSMGSQLSSAASGMGLLMLMGMPPFLGFLAKVLVFLMSGSPVIVACIMGSVISLKFYIDFFYSMVMKSLVDKNKVEVKAIWSLVICMNIMGGALILVSFI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NFRA_STAAR
Sequence: MSDHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEQIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVARVREILDLPDYVFPLFGMAVGEPAEDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISKYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
What is the function of this protein?
Reduces FMN, organic nitro compounds and disulfide DTNB.  Involved in maintenance of the cellular redox state and the disulfide stress response (By similarity).
What are the official names of this protein?
NADPH-dependent oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the flavin oxidoreductase frp family.
Protein: NUSA_MYCTU
Sequence: MNIDMAALHAIEVDRGISVNELLETIKSALLTAYRHTQGHQTDARIEIDRKTGVVRVIARETDEAGNLISEWDDTPEGFGRIAATTARQVMLQRFRDAENERTYGEFSTREGEIVAGVIQRDSRANARGLVVVRIGTETKASEGVIPAAEQVPGESYEHGNRLRCYVVGVTRGAREPLITLSRTHPNLVRKLFSLEVPEIADGSVEIVAVAREAGHRSKIAVRSNVAGLNAKGACIGPMGQRVRNVMSELSGEKIDIIDYDDDPARFVANALSPAKVVSVSVIDQTARAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRGDAPPPPPGQPEPGVSRGMAHDR
What is the function of this protein?
Participates in both transcription termination and antitermination.
What are the official names of this protein?
Transcription termination/antitermination protein NusA.
What is the protein family that this protein belongs to?
Belongs to the NusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDAC8_XENLA
Sequence: MSRVVKPKVASMEEMAAFHTDAYLQHLHKVSEEGDNDDPETLEYGLGYDCPITEGIYDYAAAVGGATLTAAEQLIEGKTRIAVNWPGGWHHAKKDEASGFCYLNDAVLGILKLREKFDRVLYVDMDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDIGLGKGRYYSINVPLQDGIQDDKYYQICEGVLKEVFTTFNPEAVVLQLGADTIAGDPMCSFNMTPEGIGKCLKYVLQWQLPTLILGGGGYHLPNTARCWTYLTALIVGRTLSSEIPDHEFFTEYGPDYVLEITPSCRPDRNDTQKVQEILQSIKGNLKRVV
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Also involved in the deacetylation of non-histone proteins.  In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
What are the official names of this protein?
Histone deacetylase 8, HD8, Protein deacetylase HDAC8, Protein decrotonylase HDAC8.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Protein: PGLRA_NEOFI
Sequence: MRSVELLSLAALGSLVAAAPAPSRVSDLTKRSSTCTFTAASQATESASGCSEIVLDNIEVPAGETLDLSDVDDGTTIVFEGTTTFGYKEWSGPLIRFGGKDITVKQNSGAVIDGEGSRWWDGEGTNGGKTKPKFMYAHSLEDSTITGLSIKNTPVQAISVQATNLYLIDITIDNSDGDDNGGHNTDGFDISESTGVYIRGATVKNQDDCIAINSGENIEFSGGTCSGGHGLSIGSVGGRDDNTVKNVTITDSTVTDSANGVRIKTVYDATGSVSEVTYSNIKLSGITDYGIVIEQDYENGSPTGTPTTGVPITDLTIDGVTGTVESDAVEVYILCGDGSCSDWTWEGVDITGGETSSKCENVPSGASC
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.  Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity).
What are the official names of this protein?
Probable endopolygalacturonase A, Pectinase A, Polygalacturonase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1581_AQUAE
Sequence: MKKLLILLTFVSFVFSKTFYYDVYVFFFRVGEIKIQIDKEKSYAEGKTLESMKWLYSYDFRFYEEKGDMKLYEREKEKVRVFGKDKIYEKKPWIPLLVDYLKTGKVKENNLFKVKKEGNKFIVIPLKSKRVKKIILKDGKVPKEIVIHGKVKIKLKLRKAEDDKGTV
What are the official names of this protein?
Uncharacterized protein aq_1581.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LEU3_STAHJ
Sequence: MTYNIVALPGDGIGPEILSGTLELLELISKKYKFDYQLTSYDFGGAAIDSHGVPLPDDTLNACKNADAILLGAVGGPQWTDPNNRPEQGLLALRKSLGLFANIRPTKVTEGTSHFSPIKESRVKGTDFIIVRELTSGLYFGEPRHIDNQSALDSLTYTKKEIERIAMVAFELASQRKKKLTSVDKENVLATSKLWRKTINEISHEFPDVKVNHLLVDACSMQLISQPTNFDVIVTENLFGDILSDEASTIPGSLGLSPSASFSLEGPRLYEPIHGSAPDIANQNLANPFGMILSLAMCLRESFNFEDAASELEQAVYQLIKDGKTTKDLNGHYTTSDIFNELKKNY
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDCC_STRMK
Sequence: METLDYRFEGHTAVQFPRGAVLVGVLASGNLEILLEPAALDGAMTVRIITAAKGFGSVWQAVISDFAQRHPLRDVRISINDAGATPAVVSLRLDQAVETLLAGEPR
What is the function of this protein?
Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.
What are the official names of this protein?
Malonate decarboxylase acyl carrier protein, Malonate decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the MdcC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LON_NEOSM
Sequence: MSEEELNNRDTESKQEHDENNSNFEAGSAHMNLPVLPLREVIFFPGDYLPIFIGRKGSIQAMDKALAETSENTGRMLLIAQKNPKKEIPEGKDLYEVGVIAKIAEPKINLQDGGVKLMVIVECRARAVNFRKSEGVLEADVLPIEEEESDNVDIEAYRRAVVQNFEKCVKLSETIPDEIIGLLSQIDSTSRIADLVTASINLKLSVKQEILETVDLLERIKKVHALLEKELGVLQVKQQIKEKTESQIKKSHKVYLLNEQLKAITKELYDKEGEEYDELVDLEKKIGNGKLSAEAKEKVSKELKKLKNMVPMSAEATVVRNYVDWIISLPWKKKGKMITDIAASERILKASHYGIEKVKERIIEYLAVQNRTKSFKGSILCLLGPPGVGKTSLASAIAEATGRPFVRMSLGGIKDESEIKGHRRTYIGAMPGKIIQHMKKAKLSNPVFLLDEIDKMSSDFRSDPAFALLEVLDPEQNAHFVDHYLEVEYDLSDVMFVATANSLNMIPALLDRLEIIRLEAYSEEEKLQIAEHYLIGKLQREHGLKKSEWSISKEALKLLIRRYTRESGVRNLKRELANLMRKAVKKLGVQSGLKSIEVSVKNLKKYAGVEKYTFGTAEPENLVGMTTGLAYTQTGGDLIMIEAVLLPGKGEIRSTGKLGEVMQESVQAAYSFVCSNCNKFGFTSKFFKSKDVHLHVPEGATSKDGPSAGVAICTSIVSVMTGIPVRSNVAMTGEVSLRGKVMEIGGLKEKLLAAVRGGIKIVLIPASNEKDLENIPKSVKNAVRIIPVSTVSEALTFTLAEQPTPLAVDVWPDIPLSSTQQSEQRV
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_LATSS
Sequence: MYAIIKTGGKQYKVEAGQAIYVEKLTAEAGEKVTFDQVILVGGETTKVGTPNIDGVTVDGTVEKQGREKKVVTFKYKPKKHSHQKKGHRQPYTKVMIDAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: ACCD_LATSS
Sequence: MQLFNAVRNIGKAHLKYNQEARQKVPDGLWVACPKCQQSIYHKDLGYYRTCPVCQYGFRTRAKVRLDWLVDSFEPAGDLAQTPNPLHFPKYPQKLRKAQQITGLEDSILTGVATIKQQKFALGIMDPYFIMGSMGSATGEKITRLFELATEKGLPVILIAASGGARMQEGIFSLMQMAKTSAAVKQHAEQGLLYISLLTDPTTGGVTASFATEADIILAEPKAVIGFAGRRVIEQTMHEQIAPDLQDAETVLKNGFIDQIVARQDQKKVLHQLLKLHERGAHY
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YSDD_ECOLI
Sequence: MTIDKNWLNRSNKDPGRSLRFTHQPV
What are the official names of this protein?
Protein YsdD.
Protein: CISH_MOUSE
Sequence: MVLCVQGSCPLLAVEQIGRRPLWAQSLELPGPAMQPLPTGAFPEEVTEETPVQAENEPKVLDPEGDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDPAPTPALPMSKQDAPSDSVLPIPVATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL
What is the function of this protein?
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.  CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor.  Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation.  May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Cytokine-inducible SH2-containing protein, CIS, CIS-1, Suppressor of cytokine signaling, SOCS.