PharMolix/UniProtQA huggingface dataset:
Protein: ACSA_BRUMB
Sequence: MSEKLYPVLPEAKKNTLIDNETYLEWYEESVSDPDGFWAKHGRRIDWFKPFTKVKNTDFNGDVTIKWYEDGVTNVSYNCIDRHLKSRGDKVAIIWEGDNPYIDKKITYRELYENVCRMANVLKKHGVKKGDRVTIYLPMIPEAAYAMLACARIGAVHSVVFAGFSPEALAGRIVDCESTFVITADEGVRGGKPVALKENTDTAIDIAAKQYVMVNKVLVVRRTGGKVSWGRGRDLWYHQEVASVEPHCEPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYHDGEIYWCTADVGWVTGHSYIVYGPLANGATTLMFEGVPNFPDQGRFWEVVDKHHVNIFYTAPTALRALMGAGDEFVTRSSRSTLRLLGSVGEPINPEAWEWYYNVVGDQKCPIVDTWWQTENGGILITPLPGATDLKPGSATRPFFGVKPVLVDNEGNVQECVADGNLCISDSWPGQMRTVYGDHKRFIETYFSTYKGMYFSGDGCRRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVSHHSVSEAAVVGYPHPIKGQGIYCYVTLMTGADAQDPDELRKELVQHVRKEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDEFGALGDTSTLADRGVVDDLIENRQNKK
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: MTFR1_DANRE
Sequence: MSRNHRRIEMDLAVGSSSKHYGSSRSIVRRIATNLPLAPCPRVHFQLHPFASGASFLNSPNGPNVATLADVAWIDREESDGPGRIRCEADSGLVFRTQERRPLRRQRSLPSLHQVEPAQQSQTVINDEAIQKISVLETELAKLRAQIAQIVQAQEQSAQSTAPAPGGPPVPPPMVPVPPPPPPPPPCPTPSMQRSYSAIDLIRERRGKKAEQNTVLDSAPKKPELPNMLDVLKDMGKVKLRSVKSHQEDGNVKAKPVEPTDAAAMIAEALKRKFAHRYRNDSECDGTFTFTAFENKPHVETPLFGQHMLKSTGRRKMH
What is the function of this protein?
May play a role in mitochondrial aerobic respiration.  May also regulate mitochondrial organization and fission (By similarity).
What are the official names of this protein?
Mitochondrial fission regulator 1.
What is the protein family that this protein belongs to?
Belongs to the MTFR1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ENOPH_KOMPG
Sequence: MAVYDTIILDIEGTVCSISFVKNVLFPYFLDKLPFLLEQVEFPLDHTDNVTVTQILAKFPERYTKSKECLKTYINELVANDIKDPTLKQLQGIVWQAGYEEGEIVVDLYNDVIEALDRWKKEDKSVYIYSSGSIKAQKLLFSHVKFKSETRDLTNYIKGYYDPTSVGSKIESESYLNILKDLNKDPESAIFLSDNIKEVAASIRAGIKSLVVKRPGNTVHHDNQSFDFVYSFDNV
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HEM1_CHLT3
Sequence: MNLIAVGVNHNTAPIELREKISLTDSMARSLLTELIDSKLASEALVLSTCNRTELYVVPAMPEVTANYLKDYLIAHKGVRKEVTRDHFFNYFACGAARHFYNVACAIDSLILGEVQIIGQVKTAYNRAVEMKTVGPILNKMCHTGFGLANRVRSKTKLTAGAVSVSYAAVELTQKIYSDVSTKNILLVGAGDTAKLAAKNLLDKRVRDFYITNRTYEKAELLAQELGTGKILPLEEMTERLHEFDIVVTAVGGNDHIIKKEHVAAAMQKRHRDPILILDLGLPRNVAPEVGQVNNVFLKDIDDLKMIIDSNLEKRRAEIPKVKHFIQKELIEYARWYFSLEVKPTIVDLQEKFFEIKALELARIKNKVSAEEYERMEQLSDRIIKKLLHFPITTLKQQTADTTDPVSFIRNIFDLKEQEEEFPGLTFPINLKEQNNN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RLMN_TOLAT
Sequence: MSENKVNLLDFDRNALRAFFADELGEKAFRADQIMKWIYHFGCDDFSQMTNVNKALREKLARIAEIRAPEISTEQRSSDGTIKWAMRVGDQEVETVYIPEADRATLCVSSQVGCALECKFCSTGQQGFNRNLTVSEIIGQVWRAAQVVGFPKDTGKRVITNVVMMGMGEPLLNLSNLVPALSLMMEDFGFGLSKRRVTVSTSGVVPALDKLGDMIDVALAISLHAPNDKLRSEIMPINDKYNIQEFLGSVQRYLSKSNANHGRVTVEYVLLDHVNDDMEHARELAELLKDTPSKINLIPFNPFPSNPYGKPSNSRVDRFSKVLMEYGYTVIVRKTRGDDIDAACGQLVGDVIDRTKRTMKKRMQEQEISVKML
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBS_LISMC
Sequence: MKTLILLIQFFTRIPLPVQINMDEINLKKGSALLPFVGVIIGAWNWLIFTLVALLMPLPVAIIAGLFAEIIITGGFHVDALADTADGLFSSRKRERMLEIMKDSRVGANGVIAICFYFLFYGSLFLSVPDTQQIGWLFFVLPIVAKGVTMLLFAKMTYAGSKAGLGSIFLGVPWWPVVIAQVIVLVALGLFFSYIGVIAYAGVILFTIIYRAFVYKRIGGMNGDTLGAGGQMGQLICLFCLVLLWGLI
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUKB_ECOL6
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFELGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADSAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNSLNQLSEQCGEEFTSSQDVTEFLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLNQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGSDEAPSQAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: ATP6_STRA1
Sequence: MESTSNPTVSFLGIDFDLTILAMSLLTITIIFILVFWASRKMTIKPKGKQNVLEYVYELVNNTISQNLGHYTKNYSLLMFILFSFVFIANNLGLMTSLKTHEHNFWTSPTANFGVDITLSLLVAFICHIEGIRKKGIGGYLKGFLSPTPAMLPMNLLEEVTNVASLALRLFGNIFSGEVVTGLLLQLAVLSPFTGPLAFALNIVWTAFSMFIGFIQAYVFIILSSSYIGHKVHGDEEE
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HMGL_WHEAT
Sequence: MKGAKSKGAAKADAKLAVKSKGAEKPAAKGKKGKAGKDPNKPKRAPSAFFVFMGEFREEFKQKNPKNKSVAAVGKAAGERWKSLSESEKAPYVAKANKLKGEYNKAIAAYNKGESAAAAAPKKAAAKEVEEEDEEESDKSKSEINDDDDDEGSDEDEDDDE
What are the official names of this protein?
HMG1/2-like protein.
What is the protein family that this protein belongs to?
Belongs to the HMGB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIOW_VEIPT
Sequence: MDELYSVRMRAAQGGPHENGGHHISGAERIVTLNQVGFIAQSLAERALHHSKGTADFINITVDLIPSETITYIDCLKVKEHTANTVTEAHQLAVKLLQGTDISESAIRNSIFLLKSLVSSMRGAMLVDAISGERLDAGNRGVRVSHMDSFDSDKLGDNEHMREALVLASKVQSAEGIVGELCWSDDPDYTIGYVACNGVYHRIPNMKEIGSNLGGRVFFVKPNIDLEGVIEYLEKEPVLVQW
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: Y557_PICTO
Sequence: MDYRHDLIIKLYDALIKNGFNVSEPDLYGLVTFDLICRRNDEKYIIKVLYNIDTFSRLSISSLMAMASVTKSSIIVIGEKSGSGRLEDGILYYRHHIPIMSFKTFIDYINGESPYIYSAPGGYYVSIDGDKMRRIRELKGYSVGYLSSKLGISRRSISLYESGSSATIDIYLKLEETLGEDLTKDIDIRNEKYDYNIKDDIKDVFIRETFQMLSALGYSYEYIKKSPFDGFSYDPETMFMLGIFNNYMENERIISIKKISQVLNNIPLIIQKEYTEKENIYGCPVVSISELRSMGSMYAFKKLVEKRYSYD
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein PTO0557.
Protein: DAPD_SALDC
Sequence: MQQLQNVIETAFERRADITPANVDTVTREAVNQVISLLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVIDGAESRYFDKVPMKFADYDEARFQKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYLGQSTKIYDRETGEVHYGRVPAGSVVVSGNLPSKDGKYSLYCAVIVKKVDAKTRGKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_AZOVD
Sequence: MFAPLLRVLFGSKNDREVKRMRRAVRAINALEEQMVALTDEQLRAKTEEFRGRLGKGETLDQLLPEAFAVAREAGKRVMGMRHFDVQLIGGMVLHEGKIAEMRTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLARRDANWMRPLYEFLGLSVGVVTPFQPPEEKRAAYAADITYGTNNEFGFDYLRDNMAFSLEDKFQRELNYAVIDEVDSILIDEARTPLIISGQAEDSSQLYLQINALIPRLKRHIEEEEGVVTQEGHYVVDEKTRQIELNEQGHQFIEELLASAGLLPEGDNLYSAHNLQLLTHVYAGLRAHVLFHRNVEYIVQGNQVLLIDEHTGRTMQGRRLSEGLHQAIEAKEGLPIQAESQTLASTTFQNYFRLYHKLAGMTGTADTEAFEFRQIYGLDVVVIPTHRPIARKDFNDLVYLTQEEKYAAIIGDIKECQTQGRPVLVGTASIESSEYVSQLLKKEGIAHQVLNAKYHEKEAEIIAQAGRPGAVTIATNMAGRGTDILLGGNWEVEVAALENPTDEPVAQIKADWQKRHQQVIEAGGLHVIASERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDNLMRIFASDRVKNFMKALGMQAGEAIEHRMVTNAIEKAQRKVEGRNFDMRKQLLEFDDVANEQRKVIYHMRNSLLESEDIGETIAEFRREVLGAAIGQHIPPQSLPEQWDVAGLEAVLQSDFGVQLPLQQWLDEDDRLHEEALRERILEALLVAYREKEEIAGTEALRTFEKQILLRVLDDLWKDHLLTMDHLRHGIHLRGYAQKNPKQEYKRESFELFQSLLESIKRDAIRVLSHVQVRREDPAEEEERLRREAEALARRMQFQHAAASALAPQAEEDDLEVVEEVPLPGTAPVRPEPKIGRNEPCPCGSGKKYKHCHGQLN
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CHDC_BACCQ
Sequence: MSEATTTLDGWYCLHDLRSIDWAAWKTLSSDERGQAVSEFLNVVEKWNDVAAAKKGSHAMYTVVGQKADIMLMILRPTMEELNEIETELNKTTLAEYMVPAYSYVSVVELSNYLPADEDPYQNPQILARLYPELPKANHICFYPMDKRRQGDDNWYMLPMEERKKMMYSHSKIGRQYAGKVRQVISGSVGFDDFEWGVTLFADDVLQFKKLIYEMRFDEVSARYGEFGTFFVGNILPDEKVEKFLHI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: MDTB_ESCF3
Sequence: MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVNDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLVEKLQQLPQLSDVSSDWQDQGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNMPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLVVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THRB_RAT
Sequence: MLHVRGLGLPGCLALAALASLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGLNYHGNVSVTHTGIECQLWRSRYPHRPDINSTTHPGADLKENFCRNPDSSTSGPWCYTTDPTVRREECSIPVCGQEGRTTVKMTPRSRGSKENLSPPLGECLLERGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQNFDPEVKLVQNFCRNPDRDEEGAWCFVAQQPGFEYCSLNYCDEAVGEENHDGDESIAGRTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPYNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKVIDQHR
What is the function of this protein?
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.  Functions in blood homeostasis, inflammation and wound healing.
What are the official names of this protein?
Prothrombin, Coagulation factor II.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: RSMI_SYNY3
Sequence: MGILYLVATPIGNLGDMTPRAVETLQTVDLIAAEDTRHTGKLLQHFQITTPQISYHDHNRHGRTQELLAKLQAGQNIALVSDAGTPGISDPGQELVAACGEANIEVIPIPGATALIAALISSGLATDRFVFEGFLSTKNRPRQQLLQSLAQEERTIILYEAPHRLLATLTDLQTFLGQERSLTVARELTKYHEQFWRGTLQTAIAYFTENTPKGEFCLVIAGATPEDRPSFSEENLRDELRSLMAKGLTRSQASRQLAEETKLPRRQLYQLSLELEADG
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_SHIBS
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP151_IXORI
Sequence: MESFVAMKVVCITVLFVIVAVNESATSEARTSSAAKETKKKNVTLHFPSYIRNPQKLALELLEICKNNKSRNSLPSTNYSAINDKYVDFKNCTFLCKHAEDRNVTLDLPPNTLCGPNGETCAEKSKCVGHIPGC
What is the function of this protein?
Salivary tick protein that downregulates host immune system by binding to both dendritic cells, and CD4(+) T cells.  Specifically binds to the CD4 coreceptor on T cells.  This interaction prevents the activation of the Src kinase, Lck, and its downstreamsubstrate Zap-70, and results in deficient activation of PLCgamma1, the repression of calcium fluxes triggered by T-cell antigen receptor (TCR) ligation, and a subsequent reduction in interleukin-2 production.  This salivary protein also binds to DC-SIGN (CD209) on dendritic cells (DC) and activates the Raf-1 kinase/MEK signaling pathway that results in down-regulating expression of pro-inflammatory cytokines.  Furthermore, it inhibits T cell proliferation induced by DCs (By similarity).  In addition, it inhibits in vitro keratinocyte inflammation induced by Borrelia burgdorferi or by the major outer surface protein (OspC) of Borrelia (PubMed:21134970).  In addition, it downregulates chemokines and monocyte chemoattractant protein 1, as well as several antimicrobial peptides such as defensins, cathelicidin, psoriasin, and RNase 7 (PubMed:21134970).  Apart from its immunomodulatory activities, it is also associated with protection of Borrelia spirochetes from antibody-mediated killing through its binding to OspC (PubMed:18752445, PubMed:33401196).  In vivo, tests on different immune disease animal models show promising therapeutic results, e. g. , in inhibiting HIV infection, experimental autoimmune encephalomyelitis, transplantation rejection, and asthma (By similarity).
What are the official names of this protein?
Salivary protein 15 Iric-1, Salp15 Iric-1, Probable ortholog of I.scapularis salivary protein 15, Salp15-like.
What is the protein family that this protein belongs to?
Belongs to the salp15 family.
Protein: LIPB_BRADU
Sequence: MVNSPQNPRQDQRQDLDLTSFSATGGEPVEWRISDAPVPYPEAVAAMEARVAAIAAGEAPELVWLLEHPPLYTSGTSGKDSDLLDPRFPTFATGRGGQLTYHGPGQRVAYIMLDLKRRRPDVRAYVASLEELILKTLAAFNVRGERREDRVGVWVKRPDKGDGYEDKIAAIGVRLKRWVSFHGIAINVEPELSHFAGIVPCGVADPRYGVTSLVDLGQLVTMADVDVALRQAFEELFGPTRALVPEAAA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_DROAZ
Sequence: MSTWANLGLQDSASPLMEQLIFFHDHALLILVMITVLVGYLMFMLFFNSYVNRFLLHGQLIEMIWTILPAIILLFIAMPSLRLLYLLDEINEPSITLKSIGHQWYWSYEYSDFNNVEFDSYMIPTNELANDGFRLLDVDNRIVLPMNSQIRILVTAADVIHSWTVPALGVKVDGTPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESVPVNYFIKWISNSVNS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: T3HPD_PONAB
Sequence: MESALALPRLPPHDPGTPVLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLVPATPAGTREARVNIHCPCGLVTAFVACEDGRSHGPVRFHSVPAFVLATDLMVDVPGHGKVVVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTKAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVIARIALQYHKGLLELNQTRAFKSSATGSVFTGKAVREAKCGDFKAVIVEVSGQAHYTGTASFIVEDDDPLRDGFLLK
What is the function of this protein?
Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C).
What are the official names of this protein?
Trans-L-3-hydroxyproline dehydratase, Trans-3-hydroxy-L-proline dehydratase.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: RL13_GEOMG
Sequence: MKTTKVAKKEEVTRDWFLVDADNKVLGRMATEIANILRGKKKPIYTPSVDTGDFVVVVNAEKIQLTGNKLADKMYYSHSGFPGGIKSIAAGKLIEKKPEDLIRKAVKGMLPKNKLARHMLKKLKVYAGPAHPHEAQQPKTLEI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.