PharMolix/UniProtQA huggingface dataset:
Protein: UBP33_XENTR
Sequence: MSSLVCDCPHLESVGEVTKEELIKKSHGSCQDCRVRGPNLWACLENGCSYVGCGESHVDHSTLHSQDTKHCLTVNLTTLRVWCYTCSKEVFLDRKLSTQPTSAKLQDSHTQESKMSSSLTLKIPAAVVSENLDIELEEEDELKTRGLTGLKNIGNTCYMNAALQALSNCPPLTHYFLDCGGLARTDKKPALCKSYQKLMSDIWHKNRPGFVIPTNLFQGIKSVNPTFRGYSQQDAQEFLRCLMDVLHEELKEQIVEVEEDAQTGIVEENLDEDKSQSDNDFHSCDSGSSSDHAESESRKLSEELTESTMLIHEDQKDVESCKTWQKEKKFSNNLNQNHFLQDFEKNIQSTIEESECLKQETVKVQIQSKAADFTAEVNMNDLPTSQTPLLNEGATTHLSSSPPKPGAVWTGHKKVPGLCPAKKRKQKKYHSVIADIFDGTIVSSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHQSSLVKAGSCGEAYAPQGWIAFFLEYFKSWFWGPTVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRFRHELMFSTKIGTHVSFPLEGLDLQPFLAKDSPSQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSEATVQNAEAYVLFYRKASEEAQKERRRVSCLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKASFIEDLVVMLPQNIWDYLYSRYGGGPAVNHLYVCYTCQTEMEKIEKRRKMELETFIRLNKAFQEEESPAVIYCISMQWFREWEGFVKSKDSDPPGPIDNTKIAAAKCGHITLRQGADSGQISEETWLFLQSIYGGGPEITLRQNVTLAESEGGHAEEKIDVETRNI
What is the function of this protein?
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling.  Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate.  Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling.  Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1.  Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2).  Deubiquitinates dio2, thereby regulating thyroid hormone regulation.  Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 33, Deubiquitinating enzyme 33, Ubiquitin thioesterase 33, Ubiquitin-specific-processing protease 33.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP20/USP33 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (By similarity).
Protein: TOM40_MOUSE
Sequence: MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGLGTGSSTGRGSERTPGAAASGAAAASEDGSCGCLPNPGTFEECHRKCKELFPVQMEGVKLTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG
What is the function of this protein?
Channel-forming protein essential for import of protein precursors into mitochondria.  Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria.
What are the official names of this protein?
Mitochondrial import receptor subunit TOM40 homolog, Mitochondrial outer membrane protein of 35 kDa, MOM35, Protein Haymaker, Translocase of outer membrane 40 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the Tom40 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=Associates with the mitochondria-associated ER membrane via interaction with BCAP31.
Protein: IMPA1_RAT
Sequence: MADPWQECMDYAVILARQAGEMIREALKNKMDVMIKSSPADLVTVTDQKVEKMLMSSIKEKYPYHSFIGEESVASGEKTVFTEQPTWIIDPIDGTTNFVHRFPFVAVSIGFVVNKEMEFGVVYSCVEDKMYTGRKGKGAFCNGQKLRVSQQEDITKSLLVTELGSSRKPETLRIVLSNMERLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDMAGAGIIVIEAGGVLLDVTGGPFDLMSRRIIAASNIALAERIAKELEIIPLQRDDES
What is the function of this protein?
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain.  Has broad substrate specificity and can use myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity).  Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate.
What are the official names of this protein?
Inositol monophosphatase 1, IMP 1, IMPase 1, D-galactose 1-phosphate phosphatase, Inositol-1(or 4)-monophosphatase 1, Lithium-sensitive myo-inositol monophosphatase A1.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PI_CHLMU
Sequence: MGKSFLDCESLIALQEIATNPVDLTLPGTLSQDRIQQYALSAEGFTYSYATERVDDRSLNALRMLAEERELIKQMESMQQGAVMNYIEGFQSESRSVLHTATRAWVRDHDLKDEAASIANHSEREAHRLAEFLYAARSKFSTLVQIGIGGSELGPKAMYFAMQGICPSDKRIFFVSNIDPDNAAEVLKEVDLKQTLIVVVSKSGTTLEPSVNEELFKRAYQDKGLSVADHFVAVTAEGSPMDDKTHYLEVFHLWDSVGGRFSATSMVGGVVLGFAFGYEVFFEFLQGAASMDAHALTPIMEKNLPLLSAMLGIWNRNVLKYPTTAVIPYATGLKYFTAHLQQCGMESNGKSISRQGKEVHFATSPIIWGDVGTNCQHSFFQSLHQGTDIVPVEFIGFLQNQRGIDCVLSGSSSSQKLFANLVAQSLALAQGRDNDNPNKRFKGNRPSSILVAQQLSPRIAGGLLAFYEHKFAFQGFCWGINSFDQEGVSLGKELATQIIGLMSGAAPIEFPEARELLRLFNVLQ
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHSD_ASCSU
Sequence: MLSAVRRAIPLSARILRTSLIQRCAGATSAAVTGAAPPQFDPIAAEKGFKPLHSHGTLFKIERYFAAAMVPLIPAAYFIHGREMDLCLALALTLHVHWGVWGVVNDYGRPFVLGDTLAAAVRVGAYIFTACLLAGLLYFNEHDVGLTRAFEMVWEL
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, CybS, Cytochrome b558 small subunit, Succinate-ubiquinone reductase membrane anchor subunit.
What is the protein family that this protein belongs to?
Belongs to the CybS family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MED27_DANRE
Sequence: MADVMNVGVNLEAFSQAINAIQALRSSVTRVFDFLKDGMKNKETLESREKVFITEFQENLQSVNRDLNELERLSTLVGRPSESHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASSLLNQQSLKRSANQMGTSAKRRPKVQPSTLALPTQYVDDVISRIGRMFPDMSIELFRPNGTSAVLLVTLGKVLKAIVVMRSLFIDRTIVRGFHENIYTEDRKLDIWSKSNYQAFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQTPCQRCGKYLQEGLPPTWRDFRTLEAFHDTCRQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).  Required for the development of dopaminergic amacrine cells in the retina.  May also negatively regulate the development of rod photoreceptor cells.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 27, Cofactor required for Sp1 transcriptional activation subunit 8, CRSP complex subunit 8, Mediator complex subunit 27.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 27 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1331_GEOKA
Sequence: MLAKHKLARINELAKKAKTAGLSAEEAFEQAKLRREYIQAFRKAMTDMLHTVTVIDPSGNDVTPKKLKESQRRRFH
What are the official names of this protein?
UPF0291 protein GK1331.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_YERE8
Sequence: MGLSTLEQKLTEIISAPVEALGYELVGIEFIRGRQSTLRIYIDSDDGITVDACADVSHQVSAVLDVEDPITVAYNLEVSSPGLERPMFTAEHYTRYLGEEVTLVLRMAMQNRRKWQGIIKAVDGEMITVTVDGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSPH1_MOUSE
Sequence: MSDLGSEELEEEGENDLGEYEGERNEVGERHGHGKARLPNGDTYEGSYEFGKRHGQGTYKFKNGARYTGDYVKNKKHGQGTFIYPDGSRYEGEWADDQRHGQGVYYYVNNDTYTGEWFNHQRHGQGTYLYAETGSKYVGTWVHGQQEGAAELIHLNHRYQGKFMNKNPVGPGKYVFDIGCEQHGEYRLTDTERGEEEEEEETLVNIVPKWKALNITELALWTPTLSEEQPPPEGQGQEEPQGLTGVGDPSEDIQAEGFEGELEPRGADEDVDTFRQESQENSYDIDQGNLNFDEEPSDLQD
What is the function of this protein?
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
What are the official names of this protein?
Radial spoke head 1 homolog, Male meiotic metaphase chromosome-associated acidic protein, Meichroacidin, Testis-specific gene A2 protein.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome. Cell projection, cilium. Note=Cytoplasmic in late spermatocytes, secondary spermatocytes and round spermatids. Gathered around metaphase chromosomes during meiotic divisions.
Protein: ENGB_BACC4
Sequence: MKVTKADIVISAVKPEQYPDSDLPEIALAGRSNVGKSSFINKILNRKKLVRISSKPGKTQTLNFFLINEMMHFVDVPGYGYAKVSKSERAAWGKMIETYFTTREQLDAAVLVVDLRHQPTSDDVMMYDFLKHYEIPTIIIATKADKIPKGKWQKHLKVVKETLAVEIGDEIVLFSSETGLGKEEAWKAIHKFTKTKNA
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: PTH_ACIBC
Sequence: MSNISLIVGLGNPGSEYAQTRHNAGFWFVEQLADKYGITLKNDPKFHGISGRGNIEGHDVRLLLPMTYMNRSGQSVVPFSKFYQIAPEAILIAHDELDMNPGVIRLKTGGGHGGHNGLRDIVPHIGPNFHRLRIGIGHPGSKERVSGHVLGKAPSSEQSLMDGAIDHALSKVKLLVQGQVPQAMNQINAYKPA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCIN_MOUSE
Sequence: MAQELQHPEFARAGQQAGLQVWRVEKLELVPVPQGAYGDFYVGDAYLVLHTTKSSRGFSYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWESFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVAIGIRDNERKGRSQLIVVEEGSEPSELMKVLGRKPELPDGDNDDDVVADISNRKMAKLYMVSDASGSMKVTLVAEENPFSMGMLLSEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLQKMKYSTNTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGKVYITEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGGVEIWRVENSGRVQIDPSSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKEGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDTFVLKLPRNNGFIWIGKGASQEEEKGAEYVADVLKCKASRIQEGKEPEEFWNSLGGRGDYQTSPLLETRAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW
What is the function of this protein?
Fails to nucleate actin polymerization, although it severs and caps actin filaments in a Ca(2+)-dependent manner.
What are the official names of this protein?
Scinderin, Adseverin, Gelsolin-like protein.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, podosome.
Protein: TFF3_RAT
Sequence: METRAFWTTLLLVLVAGSSCKAQEFVGLSPSQCMVPANVRVDCGYPTVTSEQCNNRGCCFDSSIPNVPWCFKPLQETECTF
What is the function of this protein?
Involved in the maintenance and repair of the intestinal mucosa.  Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity).
What are the official names of this protein?
Trefoil factor 3, Intestinal trefoil factor, rITF, Polypeptide P1.B, rP1.B.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Cytoplasm.
Protein: ATP6_SALPC
Sequence: MASENMTPQEYIGHHLNNLQLDLRTFSLVDPQNPPATFWTLNIDSMFFSVVLGLLFLVMFRSVAKKATSGVPGKFQTAIELIVGFVHGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHWLGLPATRVVPSADVNITLSMALGVFILILFYSIKMKGIGGFAKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPWAIFHILIITLQAFIFMVLTIVYLSMASEEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU2C2_OENGL
Sequence: MIWHVQNENLILDSTRIFMKAFHLPLFDGSFIFPEGILIFGLILLLMIDSTSDQTDIPWFYFISSISLVMSITALLFRWREEPRILFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHPLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDANGGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVSIGLFTSVVSIYYYLKIIKLLMTGRKQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y1374_MYCBO
Sequence: MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAPHTPPLVIDFGGGVLGALQRHADPASVHVLLSHLHADHCLDLPGLFVWRRYHPSRPSGKALLYGPSDTWSRLGAASSPYGGEIDDCSDIFDVHHWADSEPVTLGALTIVPRLVAHPTESFGLRITDPSGASLAYSGDTGICDQLVELARGVDVFLCEASWTHSPKHPPDLHLSGTEAGMVAAQAGVRELLLTHIPPWTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG
What are the official names of this protein?
Uncharacterized protein Mb1374.
What is the protein family that this protein belongs to?
Belongs to the AtsA family.
Protein: AT1A1_OREMO
Sequence: MGLGKGKDEYKLAATSEDGGKKDKKAKAKKDMDDLKKEVDLDDHKLTLDELHRKYGTDLTRGLSSSRAKEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAASEDEPANDNLYLGIVLSAVVIITGCFSYYQEAKSSKIMESFKNLVPRQALGIRDGEKKNINAEEVVLGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDFSNENPLETRNISFFSTNCIEGTARGIVINTEDRTVMGRIATLASSLEGGKTPIAIEIEHFIHIITGVAVFLGVSFFILSLILGYNWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGTSFDRSSATWANLSRIAGLCNRAVFLADQSNIPILKRDVAGDASEAALLKCIELCCGSVNEMREKYPKIAEIPFNSTNKYQLSIHKNTTPGETKHLLVMKGAPERILDRCNSIVLQGKVQALDDEMKDAFQNAYVELGGLGERVLGFCHYHLPDDEFPEGFAFDTDEVNFPTENLCFVGLMAMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNVPVSEVNPRDAKACVVHGSELKDMTSEELDDLLKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKTDKLVNERLISIAYGQIGMMQATAGFFTYFVILAENGFLPMDLIGVRVLWDDKYVNDLEDSYGQQWTYERRKIVEYSCHTAFFASIVIVQWADLIICKTRRNSIVQQGMTNRILIFGLFEETALAAFLSYCPGMDVALRMYPMKPLWWFCAFPYSLLIFLYDEARRYILRRNPGGWVEKETYY
What is the function of this protein?
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane.  This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Multi-pass membrane protein.
Protein: RUXE_YEAST
Sequence: MSNKVKTKAMVPPINCIFNFLQQQTPVTIWLFEQIGIRIKGKIVGFDEFMNVVIDEAVEIPVNSADGKEDVEKGTPLGKILLKGDNITLITSAD
What is the function of this protein?
Involved in pre-mRNA splicing.  Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site.  Involved in cap modification.
What are the official names of this protein?
Small nuclear ribonucleoprotein E, snRNP-E, Sm protein E, Sm-E, SmE.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ABHDA_MOUSE
Sequence: MAAWAPCRRWGWAAVSFGRHPGLSASLARKPPRAWWLSACRQKASLSFLNRSELPNLAYKRLKGKTPGIIFIPGYLSNMNGIKAVAVEEFCKSLGHAFIRFDYSGIGSSDGNLAECTVGKWRKDVLSILDDVAEGPQILVGSSLGGWLMLHAAIARPEKVIALIGIATAADGLVTQYHALPVETQKEIEMKGEWTLPSRYNKEGYFRIPYSFIKEAEHHCLLHSPIPVTCPVRLLHGMKDEIVPWQRSLQVADRIVSPDVDVILRKQGDHRMKEKADIHLLICTIDDLIDKLSTVVP
What is the function of this protein?
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833).  Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability (PubMed:31740833).  Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate (By similarity).
What are the official names of this protein?
Palmitoyl-protein thioesterase ABHD10, mitochondrial, Acyl-protein thioesterase ABHD10, Alpha/beta hydrolase domain-containing protein 10, Abhydrolase domain-containing protein 10, Mycophenolic acid acyl-glucuronide esterase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SMS_RAT
Sequence: MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATGKQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
What is the function of this protein?
May enhance low-glucose-induced glucagon release by pancreatic alpha cells (PubMed:24735892).  This effect may be mediated by binding to GPR107 and PKA activation (PubMed:26561648).  May regulate cardiac contractile function (PubMed:22170057).  May compromise cardiomyocyte viability (PubMed:22170057).  In the central nervous system, may impair memory retention and may affect hippocampal excitability (PubMed:21978882).  May also have anxiolytic and anorexigenic effects (PubMed:18753129, PubMed:21978882).  May play a role in arterial pressure regulation (PubMed:18753129, PubMed:21978882).  May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH (By similarity).  Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity).
What are the official names of this protein?
Somatostatin, somatotropin release-inhibiting factor, SRIF.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPA_CORJK
Sequence: MSVTADGRRMLRIEAKNAETPIESKPRWIRTTAKVGPEYRDIKNRVKGAGLHTVCQEAGCPNINECWEDREATFLIGGDTCSRRCDFCQIKSGRPSPLDMDEPRRVAENVREMGLRYATITGVTRDDLDDEGAWLYAEVVKKIHELNPNTGVENLTPDFSNRPELLKVVFDSQPEVFAHNLETVPRIFKRIRPAFKYDRSLEVIQAAHDYGLVTKSNLILGMGEKKEEVRAAIKDLADAGTDILTITQYLRPSSMHHPIERWVKPEEFMEHSDAAYELGIKAVMSGPLVRSSYRAGRLYAQAKQARGEAIPENLKHLEETLDSTTSQEASTLLERYGASEDTPVTASRR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTH_CHICK
Sequence: MCAAAPRGGGRAARRLGAATAGSRVPSAAPRYSRRTRRVPIAYEAEPKPESPGPKWEPENWQQQLERIREMRRHRDAPVDEMGVDKCYDTSAPPQVMRYQVLLSLMLSSQTKDQVTSAAMLRLRQRGLTVDSILQMDDATLGQIIYPVGFWRNKVKYIKQTTAILKQKYGGDIPGTVEELVKLPGVGPKMAHLAMNIAWNSVSGIAVDTHVHRITNRLKWVKKETRYPEETRVALEDWLPRDLWREINWLLVGFGQQTCLPVNPRCKECLNQDICPTAKRF
What is the function of this protein?
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage.  The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site.  The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination.  Primarily recognizes and repairs oxidative base damage of pyrimidines.
What are the official names of this protein?
Endonuclease III-like protein 1, Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase, DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: MURG_STAHJ
Sequence: MSKIAFTGGGTVGHVSVNLSLIPTATDKGHDAFYIGSKTGIEREMIESQLPNIEYYPISSGKLRRYLSVDNAKDVFKVLKGVIDARKVLKREKPDLLFSKGGFVSVPVVIAARSLNIPTIIHESDLTPGLANKISLKFAKKIYTTFEDTLKYLPKDKADFVGATIRQDLKEGNQSRGYQLTGFDASKKVLLVMGGSLGSKKLNQAIRENLEALLQDYQIIHLTGHGLVDSSIDAKGYVQYEFVKEELTDLLAITDTVVSRAGSNAIYEFLTLRIPMLLIPLGLDQSRGDQIDNAENFESKGYGRTIPEDQLTQVKLLEQLKEIENDRESIIKQMETYRESYTKEDLFNKILKDAL
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.