PharMolix/UniProtQA huggingface dataset:
Protein: DRE2_PICST
Sequence: MANILLLLHPTVVTDQHLVENVKADIRKSVGDAHVEQHIIDRVTRGEVELTRNTYDKIIYINPNVHNRSIPASLMKLVYETLIDEGEFSGDLPTDQALDVLMTGFIVSDTNDQCWIKPKPIESVSIPLRRKGKKTDASVSASSGTTALPLFKKLSSNSNNNNNSSSPIGLTDSSAANTDEETDEANVMKRKLDAAKLTYFSDSDSENEEDENDDIINEDDLIKDSNQLDLRSRLIIPKSCEIPNGKKRRKACKDCTCGLKEIEEQEEAQQRSLQDSILGKMAQSATLEAIKIEERLKRQPVKFKDEDLAEIDFTVEGKTGGCGSCALGDAFRCDGCPYLGMPPFKPGEIVSIDSLGEDL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35.  Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18.  TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
What are the official names of this protein?
Fe-S cluster assembly protein DRE2, Anamorsin homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: EPD1_CANMA
Sequence: MLLNSLFPSILAAATFVTSAAAEDLPPIEIVGNKFFYSNNGSQFYIKGIAYQQNNLDSNSTFVDPLADADNCKRDIPYLEQVDTNVIRVYALDVTQDHTECMQMLQDAGIYIIADLSQPDESINRNDPQWNLDLFERYTSVVDKFHNYTNVLGFFAGNEVTNNVSNTDASAFVKAAIRDTKAYIKAKGYRTIPVGYSANDDSDIRVSLARYFACGDEDESADFFGMNMYEWCGSSSFKASGYESATDDYKNLGIPIFFSEYGCNEVTPRKFQEVGTLFGSDMTDVWSGGIVYMYLQEENNYGLVSVSGSSVSTLQDFNSYKSEILDISPSSVQASAESASGVSRTSCPTNTDNWEASTELPPTPDKDICDCMSSSLKCVVADNVSTDDYSDLFDYVCAKIDCSGINANATTGDYGAYSPCGAKDKLSFVLNLYYEEQNESKSACDFSGSASLQSASTASSCAAYLSSAGVSGLGTVQGSVRTDTSEATTDSGSGSSNSGSASSSKSTSSSTSSGSSGSKSAATAVTVTTLTKIAAVGVSIIVGFGLITM
What are the official names of this protein?
Protein EPD1, Essential for pseudohyphal development 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 72 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CAP15_ARATH
Sequence: MKLWKRAAVVLKDGPSLIAADDILTAAVVKATSHDELSIDTESAQFIYRHVLSSPSSLKPLVSLISSRVKRTRSWAVALKGLMLMHGFFLCKSTVAESIGRLPFDLSSFGEGNSRIMSKSGGFNLFVRAYFAFLDRRSILFHDGNRHRYNEESSVLIRLVIIRKMQIIVDSLIRIKPIGENMMIPVINEAMENVVSEIMEIYGWICRRIAEVLPNVHSKIGKTEADLALKIVAKSMKQGGELKKYFEFCKDLGVSNAQEIPNFVRIPEADVIHLDELVRTAMESSEESAERTEIAEEEEEEEEEIETKLSDLITLDHNEEAPASPPRVVVVDIPDLISF
What are the official names of this protein?
Putative clathrin assembly protein At1g14686.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin in the Golgi area.
Protein: COX19_HUMAN
Sequence: MSTAMNFGTKSFQPRPPDKGSFPLDHLGECKSFKEKFMKCLHNNNFENALCRKESKEYLECRMERKLMLQEPLEKLGFGDLTSGKSEAKK
What is the function of this protein?
Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis (PubMed:23345593).  May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity).
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX19, hCOX19.
What is the protein family that this protein belongs to?
Belongs to the COX19 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Mitochondrion. Note=Partitions between mitochondria and the cytosol in a copper- dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated.
Protein: HIS2_NEUCR
Sequence: METTLPLPFLVGVSVPPGLNDIKEGLSREEVSCLGCVFFEVKPQTLEKILRFLKRHNVEFEPYFDVTALESIDDIITLLDAGARKVFVKTEQLADLSAYGSRVAPIVTGSSAALLSSATESGLLLSGFDQTASEAAQFLEEARDKKITPFFIKPVPGADLEQFIQVAAKANAIPILPSTGLTTKKDEAGKLAISTILSSVWKSDRPDGLLPTVVVDEHDTALGLVYSSAESVNEALRTQTGVYQSRKRGLWYKGATSGDTQELVRISLDCDNDALKFVVKQKGRFCHLDQSGCFGQLKGLPKLEQTLISRKQSAPEGSYTARLFSDEKLVRAKIMEEAEELCTAQTPQEIAFEAADLFYFALTRAVAAGVTLADIERSLDAKSWKVKRRTGDAKGKWAEKEGIKPAASALAATSAPVTKEAAQETTPEKITMRRFDASKVSTEELDAALKRPAQKSSDAIYKIIVPIIEDVRKNGDKAVLSYTHKFEKATSLTSPVLKAPFPKELMQLPEETIAAIDVSFENIRKFHAAQKEEKPLQVETMPGVVCSRFSRPIEAVGCYIPGGTAVLPSTALMLGVPAMVAGCNKIVFASPPRADGTITPEIVYVAHKVGAESIVLAGGAQAVAAMAYGTESITKVDKILGPGNQFVTAAKMFVSNDTNAAVGIDMPAGPSEVLVIADKDANPAFVASDLLSQAEHGVDSQVILIAIDLDEEHLQAIEDEVHRQATELPRVQIVRGSIAHSITVQVKTVEEAMELSNKYAPEHLILQIKEAEKAVDLVMNAGSVFIGAWTPESVGDYSAGVNHSLPTYGFAKQYSGVNLASFVKHITSSNLTAEGLKNVGQAVMQLAKVEELEAHRRAVSIRLEHMSKSN
What are the official names of this protein?
Histidine biosynthesis trifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the histidinol dehydrogenase family.
Protein: HV146_HUMAN
Sequence: MDWTWRVFCLLAVAPGAHSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGIINPSGGSTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 1-46, Ig heavy chain V-I region DOT, Ig heavy chain V-I region HG3, Ig heavy chain V-I region Mot.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: LEU3_SYNJA
Sequence: MSVPSSAVRTYRITALAGDGIGPEIMQVGRAVLDAVAAQVGFSLQWQEGLIGGAAYEATGDPLPPETLKMAQESDAVYLAAVGDFKYDTLPREKRPERALLGLRAGLGLFANLRPVKIFPQLVQASSLKPEVVAGIDLVVVRELTGGIYFGQPKGIFTDAKGSRRGVNTMAYSEAEVDRIARVAFELARKRRRKLCSVDKANVLEVSQLWRERVTAIAAEYPDVELSHLYVDNAAMQLVRWPKQFDVILTENLFGDILSDEAAMLTGSIGMLPSASLGSSGPGVYEPVHGSAPDIAGQDKANPIAQVLSGAMLLRYSLDQPQAADRIEQAVEAVLAQGYRTADIYSEGMTLVGCREMGEKILAALAQQQASPQGSLSAPGG
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUON_SODGM
Sequence: MTITPQQLIALLPLLIVGLTVVVVMLCIAWRRNHFINSTLTVIGINLALLSLWFVTQNGPMDVTPLMRVDGFSMFYTGLVLVASLATSTLAYAWLAGYPGNRDEFYLLVLIATMGGILLASANHLAALFLGIELISLPLFGMVGYAFRQKRSLEASIKYTLLSAAAASFLLFGMALVYAQTGQLSFTALGQTLNDTMLTQPVLLAGLGMMVVGLGFKLSLVPFHLWTPDVYQGAPVPVSTFLATASKIAIFAVVMRLFLYAPVTHSDTVRLVLAIIAFASMLFGNLMALSQSNIKRVLGYSSIAHLGYLLVGLIVVQAHTLALETVGVYLAGYLFASLGAFGVVSLMSSTYTGEDADSLYSYRGLFWHKPLLSSVLTVMMLSLAGIPMTLGFIGKFYVIALGVNSHLGWLTGAVVAGSAIGLFYYLRIMVSLYLSPPENLRRDMPSNWALTAGGVVVLISSLLVLLLGLYPQPLITLVQLAYPIL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCO9A_STOCO
Sequence: NVLVPPCSGCYSQSGNTCYYDVYKCPS
What is the function of this protein?
Has analgesic and anti-inflammatory activity in vivo (PubMed:36421718).  At a dose of 0. 1 and 1 mg/kg, exhibits anti-inflammatory activity by reducing the volume of edema during 24 h better than the nonsteroidal anti-inflammatory drug, Diclofenac, at dose of 1 mg/kg in a mouse model of acute local lambda-carrageenan-induced inflammation (PubMed:36421718).  At a dose of 1 mg/kg, reduces the content of tumor necrosis factor-alpha (TNF-alpha) (PubMed:36421718).  Demonstrates a significant analgesic effect on acute pain sensitivity in the carrageenan-induced thermal hyperalgesia model at doses of 0. 1 and 1 mg/kg (PubMed:36421718).  Not toxic in mice, however stimulates exploratory motivation and active search behavior, and demonstrates an anti-anxiety effect (PubMed:36421718).  Does not exhibit any effect on currents of rat acid-sensing ion channels ASIC1a or ASIC3 (PubMed:36421718).
What are the official names of this protein?
AnmTX Sco 9a-1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone structural class 9a family.
Protein: RHG18_MOUSE
Sequence: MNWLSSSSGVVLTAYHPSGKDQVAGDSHVKGGDEATSSRRYGQYTINQEGSTKVPERPPFDRSSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQEKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQAVNQKEFSKERTQKISSNDSLPSFRLPKDKTGTTRIGDLAPQDMKKVCSLSLIELTALYDVLGLEFKQQKAVKIKTRDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISRIEEGSLETEGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFLRELPQPLLSMEYLKAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAGNVAMVMAPNLFMCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQNIENQKKERKAMKKLLKKMAYDREKHEKQDKTANGADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTHMKDLYQLNPNAEWVIKSKPV
What is the function of this protein?
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho.  Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state.  Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation.  Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1.  Regulates cell shape, spreading, and migration (By similarity).
What are the official names of this protein?
Rho GTPase-activating protein 18, Rho-type GTPase-activating protein 18.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOAH_SHIDS
Sequence: MFAGLPSLTHEQQQKAVERIQELMAQGMSSGQAIALVAEELRANHSGERIVARFEDEDE
What are the official names of this protein?
UPF0181 protein YoaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0181 family.
Protein: XERC_RICPU
Sequence: MLDTSIQALINKWQKYLVLQRNYSNHTVISYNNDLKHFLEFMNYYNSELVTINHIKTADIRLIRSWLAKRNCDNFTASSISRGLSAVKNFYRFLEKTTQLNSHIIFSIKSPKKTKLLPKALSEDDVVISLEHIEEYGNVKWVELRNKALLVLIYASGLRISEALSITKLHLQNLEFIRIIGKGSKERIIPWLPIAKNLITQYLEILPYKLGDNEPIFRGKQGKELQPSVFNRELIKLKHFYGLPQHLTAHSFRHSFASHLLEHGADLRSLQELLGHKSLSTTQNYTKTSIKHLEAVYTTAYPIKK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_LEUCK
Sequence: MSTGKVVQVIGPVVDVAFESGQQVPDINNALKIDKGDGQTLTVEVSLALGDGIVRTIAMDSTDGLQRGMSVTDTGDAIKVPVGEATLGRVFNVLGEPVDNNGEIAAETPRHSIHRDAPSYDDLANSTEILETGIKVIDLLAPYVRGGKIGLFGGAGVGKTVLIQELIHNIAQGHNGISVFTGVGERTREGNDMYHEMAESGVLKQTAMVYGQMNEPPGARMRVALTGLTMAENFRDSEGKDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAVYVPADDYTDPAPATTFAHLDATTNLERALTQQGIYPAVDPLASTSSALDPQVVGQEHYEVATEVQRTLQRYRELQDIISILGMDELSDEEKTTVNRARRIQFFLSQPFSVAETFTGINGEYVPVAETVRSFKEILDGKYDDLPEDAFRNVGAIEQVVEKAKTMAQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PPE11_MYCTU
Sequence: MTSALIWMASPPEVHSALLSSGPGPGPVLAAATGWSSLGREYAAVAEELGALLAAVQAGVWQGPSAESFAAACLPYLSWLTQASADCAAAAARLEAVTAAYAAALVAMPTLAELAANHATHGAMVATNFFGINTIPIAVNEADYVRMWLQAATTMATYQAVADSAVRSIPDSVPPPRILKSNAQSQHSSSNNSGGADPVDDFIAEILKIITGGRVIWDPEAGTVNGLPYDAYTNPGTLMWWIARSLELLQDFQEFAKLLFTNPVKAFQFLVDLILFDWPTHMLQLATWLAENPQLLVAALTPAISGLGAVSGLAGLTGLVPQPPVVPAPAPDAVVPTVLPLAGTATPTTAPASAPAAGAAPGPPAGTATATSASVPTSAGGFPPYLVGSGPGIDFDAGTPAGSRRAQPAADNVTAVAAAQVSARHQARRRRRAAAKERGNADEFVDMDSGPAIPPSGERDAWASNSGVGGLGFAGTASNETVAAPAGLTTLADDEFQCGPRMPMLPGAWDLGTWDRGD
What is the function of this protein?
May play an important role in the persistence of mycobacteria in host cells.  May regulate the innate immune response of macrophages by promoting the production of pro-inflammatory cytokines and inhibiting the production of anti-inflammatory cytokines.  Promotes the death of macrophages during infection.
What are the official names of this protein?
PPE family protein PPE11.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Cell wall-associated.
Protein: NU2C2_LIRTU
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFHGSFIFPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVMSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDSITIFVAPECFSLCSYLLSGYTKRDVRSNEATTKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLIKTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFARIVSFGLRTGTDNIRDYAGLYTKDPFLALSSALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVSIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: EX7L_CHLTA
Sequence: MSITSPPIEVSVLTDSIKNLLEKNFLRVVVKGELSNVSLQTSGHLYFAIKDSKAVLNGAFFHFRSKYFDRKPKDGDYVILHGKLTVYAPRGQYQIVAYALTFSGEGNLLQQFEERKQRLAAEGYFDPKRKKPLPSGARVIGVITSPTGAVIQDILRVLSRRCHQFQVILYPVTVQGATAAQEISQAIQFFNQNSMGVHALIIARGGGSIEDLWAFNEEELVKSIVASSIPIISAVGHETDFTLCDFASDVRAPTPSAAAEIVCKSSDQYRQELQNLRRYVSSHARQFIAAKKNLLTHWQRHLASVDFYHTAQQTLDYTRAALERGIETKLEYYKQRFAQYRRWLKSDVLIRIEKHLADLNQSLMLSIKNKIYTKKTSLNQLYTSCLKNELLNLQHRTQHSRNILSQLSRRLHIAIASSQQTHQECLVRLQNELSFTIQHLLTKAKERCQAIQEQASSLNPKNVLKRGFAQLFDFNKHFVIISAESLKQSDLVRVCLQDGEAVVSVKEVWLNNDKKG
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_AZOVD
Sequence: MVSRDFGREKRLLIPRQFKAVFDSPTAKVPGKHVLLLARPNALDHPRLGLVIGKKSVKLSVGRNRLKRLIRESFRLNQDSLAGWDIVVVARKGLGELENTEVTQQFGKLWKRLARSRPQTAVEAAGSSHA
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RLMH_SULDN
Sequence: MNIEILSIAKKERSIYDPLCKELSKMISRFAKIEDIELFNKDVTKAHTISPEASREAYSKLFAPHVVKSFNVILHPDGKLIDSYEFSKLLDGKIAVKFFIGGAYGFEDEFLKKGDSIISLGNITMSHKIAKVVLLEQIYRGFSILSNHPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGAL_HUMAN
Sequence: MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSEDSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQAPCGETDSTLLIWQVPLML
What is the function of this protein?
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.
What are the official names of this protein?
Rho guanine nucleotide exchange factor 10-like protein, GrinchGEF.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTDB_PAPHA
Sequence: RCVCRRGVC
What is the function of this protein?
PhTD-1 has antimicrobial activity.  In low salt conditions PhTD-1 has antibacterial activity against the Gram-negative bacterium E. coli ML35p (MIC=1. 5 uM), the Gram-positive bacteria L. monocytogenes EGD (MIC=1. 6 uM) and methicillin-resistant S. aureus ATCC 33591 (MIC=2. 5 uM), and the fungus C. albicans 820 (MIC=1. 6 uM).  At high physiological salt concentrations the antimicrobial activity of PhTD-1 decreases slightly: E. coli ML35p (MIC=2. 0 uM), L. monocytogenes EGD (MIC=1. 7 uM), S. aureus ATCC 33591 (MIC=3. 6 uM), and C. albicans 820 (MIC=6. 5 uM).
What are the official names of this protein?
Theta defensin subunit B.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family. Theta subfamily.
Protein: BIOB_CERSK
Sequence: MIPSDLRTDWTVEEARAIHALPFPDLMHRAQTLHRAHFDPTAIETASLLSIKTGGCPEDCGYCAQSAHHDTGVKATKLMATEEVLAAARRAKAAGAQRFCMGAAWRSPKDRDMDRLCDMVQGVAELGLETCMTLGMLSPGQVARLRAAGLDFYNHNIDTSPAYYARIASTRTMEDRLETVEQVRRGGIKVCCGGILGMGEAEEDRIALLVTLATLPAHPDSVPVNLWTEIEGVPVQGRARAVDPFALVRIVALARILMPASVLRLSAGRTEMSDELQALCFLAGANSIFVGDQLLTTGNPAAWKDRDLLTRLGLHVAPARARPLVAAN
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: ARLY_KORVE
Sequence: MKMWSGRFSQSLDPEFESWQRSLPFDKKLLRHEVAASGAHATALAKAGVLSSEELALIKSGLAQIARDGAPDADDPSIEDVHHFVESRLIEIAGEVGRKLHTGRSRNEQIATDLRLYVREQIDETTLLIADVIAALIERAESVGEAAMPSYTHLQRAEPVLIAHWLLAYAEMFFRDITRLADCRKRANLCPLGSAAVAGTFVALDRGYIATLLGFDAPTANSIDATSDRDFAIEFVQSLSVIGLHLSRMAEEMILFATTEFGFLQLPEQFATGSSAMPQKKNPDSLELVRGKSAALLAHAMQLAVTLKALPLAYNKDMQETQQPVFASAEECIAMLRITAGFLRAVKFNTAVMHTAASTGYMNAMAAAGYLVQQGIPFRRAHELIGAAVKLAVEKHCELHDLSADDLRNLGIAADDSFYAALQLPAVLAQKNVAGGTAPNQVSTALKAAKKKLIAIGEVQHVSA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS181_CUPPJ
Sequence: MAFIKRDNKNKKRFQQQNPLFKRKRFCRFTVAGVEQIDYKDLDTLKDFIGDNGKITPARLTGTKAHYQRQLDTAIKRARFLALMPYTDLHKN
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: KAD_EDWI9
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKAGSELGKQAKAIMDAGKLVTDELVIALVKERIAQEDCHNGFLLDGFPRTIPQADAMKEAGINVDYVLEFAVPDELIVDRIIGRRVHPGSGRVYHVKFNPPQVEGKDDVTGEDLMTRKDDQEETVRKRLVEYHQQTAPLIGYYGQEAQAGNTRYVKIDGTQSVDSVRAELENVLG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_BURMA
Sequence: MRHYEIVFIVHPDQSEQVPAMIERYKSTITSHGGQIHRVEDWGRRQLAYMIEKLAKAHYVCMNIECDQTTLDELEHAFKFNDAVLRHLIVKMKKAETGPSPMMKEVQREEAKKAAAAQPTEAQA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.