PharMolix/UniProtQA huggingface dataset:
Protein: AUKBA_XENLA
Sequence: MSYKENLNPSSYTSKFTTPSSATAAQRVLRKEPYVSTFTTPSDNLLAQRTQLSRITPSASSSVPGRVAVSTEMPSQNTALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPPVYQSTQSK
What is the function of this protein?
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.  The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.  Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis.  Required for central/midzone spindle assembly and cleavage furrow formation.  Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage.  Phosphorylates 'Ser-10' of histone H3 during mitosis.
What are the official names of this protein?
Aurora kinase B-A, Aurora/IPL1-related kinase 2-A, AIRK2-A, XAIRK2-A, Serine/threonine-protein kinase 12-A, Serine/threonine-protein kinase aurora-B-A, xAurora-B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Chromosomal until metaphase but transfers to the midzone microtubule array and the equatorial cortex during anaphase.
Protein: Y1147_MYCLE
Sequence: MSAPMVGMVVLVVTLGAAVLALSYRLWKLRQGGTAGIMRDIPAVGGHGWRHGVIRYRGEAAAFYRLSSLRLWPDRRLSRRGVEIVARRGPRGDEFDIMTDKIVVLELRDTTQDRRSGYEIALDQGALAAFLSWLESRPSPRTRRRSV
What are the official names of this protein?
Uncharacterized protein ML1147.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1312.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS3A_BRACM
Sequence: MAVGKNKRISKGRKGGKKKIVDPFAKKDWYDIKAPSSFTHRNVGKTLVSRTQGTKIASEGLKHRVFEVSLADLNKDEDQAYRKIRLRAEDVQGRNVLTQFWGMDFTTDKLRSLVKKWQTLIESHVDVKTTDNYTLRLFCIAFTKRRANQVKRTCYAQSSQIRQIRSKMREIMIKEEASSCDLKELVAKFIPESIGKDIEKATQGIYPLQNVFIRKVKILKAPKFDLRKLMEVHGDYTAEDVGVKVDRPADEVVEEPTEIIGA
What are the official names of this protein?
40S ribosomal protein S3a, S phase-specific protein BIS289.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPLC_STAA9
Sequence: MNKNIVIKSMAALAILTSVTGINAAVVEETQQIANAEKNVTQVKDTNNFPYNGVVSFKDATGFVIGKNTIITNKHVSKDYKVGDRITAHPNGDKGNGGIYKIKSISDYPGDEDISVMNIEEQAVERGPKGFNFNENVQAFNFAKDAKVDDKIKVIGYPLPAQNSFKQFESTGTIKRIKDNILNFDAYIEPGNSGSPVLNSNNEVIGVVYGGIGKIGSEYNGAVYFTPQIKDFIQKHIEQ
What are the official names of this protein?
Serine protease SplC.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1B family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACSF2_MOUSE
Sequence: MAVYHGMLRFGRLCIASLGARGPRTLLSRPRPNSKLQSVRALSSGMVNCTNPLPIGGLSYIQGHTDSHLVNTTVGECLDATAQRFPDREALVILHENIRLNFAQLKEEVDKAASGLLSIGLRKGDRLGMWGPNSYAWVLIQLATAQAGIILVSVNPAYQSSELEYVLRKVGCKGIVFPKQFKTQQYYDILKQVCPELEKAQPGALKSERLPDLTTVISVDAPLPGTLLLDDIVAAGGKEQNLAQLRYNQRFLSCYDPINIQFTSGTTGNPKGATLSHHNIVNNSMLIGQRLKMPTKTAEELRLVLPSPLYHCLGSVGGTMVSMMHGATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTSIRGGVIAGSPAPPELIRAIINKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNVETGELTNLNVPGELYIRGYCVMQGYWGEPQKTFETVGQDKWYRTGDIALMDEQGFCKIVGRSKDMIIRGGENIYPAELEDFFLKHPQVQEAQVVGVKDERMGEEICACIRLKSGETTTAEEIKAFCKGKISHFKIPRYIVFVEGYPLTISGKIQKFKLREQMEQHLKL
What is the function of this protein?
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA.  Has some preference toward medium-chain substrates.  Plays a role in adipocyte differentiation.
What are the official names of this protein?
Medium-chain acyl-CoA ligase ACSF2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EPL1_EMENI
Sequence: MTRYAGLGRTRPKKLTPKAPIPIYREHQIDDLEEEIQNGLQQVETGVEKAEESEYHLQVAINAVASGRVVNEAHIPTPETVLSNLQYDELYPPVFSQPATYIRFSSTVEDCCGCPYNMTDEDDVFLKIMNEKRDPADRCTEDQFEEVMNFFEETVRLKQPYAAVGSAPVLSFAEMQESMDATVEDYVRRLAKDVYDHWKTRRLNNGNQSLLPSLKFETGAETDDTDPYVCFRRREVRQVRKTRGRDAQSADKLRRLRKELEDARQLVALVRQRELARKEMLATERILFLQRAEVKDMKRKLNIKDDDEDLINQKPKKKPIEAPPMQRPAAAQLRMPPKPGAQAAEDLQLLEDVQAEKENEIIRDIKANIAKHMKWNEGYVDFTRAPLSPSPERTVDISFRPAITTQLPTPPSSDSSENTPDLALDMSGTVSYRDKLDEHALIMSEDANKMPSFRRRIGRGGRLLIDRRNFASRCRVELDPWKADRFKYDQEDSDEDLDYEMDQYDISLMQNRAIMLAKARDQAHAQAQAAQVRRLQAEQAALNNLNSGQTSGQTMGSNPGPGAIAPTPET
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair.  Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
What are the official names of this protein?
Enhancer of polycomb-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the enhancer of polycomb family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURQ_STAAW
Sequence: MMENSTTEARNEATMHLDEMTVEEALITMNKEDQQVPLAVRKAIPQLTKVIKKTIAQYKKGGRLIYIGAGTSGRLGVLDAAECVPTFNTDPHEIIGIIAGGQHAMTMAVEGAEDHKKLAEEDLKNIDLTSKDVVIGIAASGKTPYVIGGLTFANTIGATTVSISCNEHAVISEIAQYPVEVKVGPEVLTGSTRLKSGTAQKLILNMISTITMVGVGKVYDNLMIDVKATNQKLIDRSVRIIQEICAITYDEAMALYQVSEHDVKVATVMGMCGISKEEATRRLLNNGDIVKRAIRDRQP
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: CYSD_GEOUR
Sequence: MNGTLTHLQQLEAESIHIIREVVAEFANPVMLYSIGKDSAVMLHLARKAFFPAPPPFPLLHVDTTWKFREMIQFRDRMAAECGLDLIVHVNEEGVKNGISPFTHGSALYTDVMKTEGLKQALDKYKFDAAFGGARRDEEKSRAKERIFSFRCTNHRWDPKNQRPELWNLYNTRIKPGESIRVFPLSNWTELDVWQYIHLENIPIVPLYYAAVRPVVERDGMLIMVDDERLELKPGEKVQYKSVRFRTLGCYPLTGAVESTADTLPQIIQEMLLTRTSERQGRLIDHDQDGSMEKKKQEGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: SGAA_METEA
Sequence: MAATRRPGRNHLFVPGPTNIPDRVMRAMMVQSEDHRSVDFPSLTKPLFEDTKKVFGSTEGTIFLFPASGTGIWESALSNTLARGDKVLAARFGQFSHLWIDMAQRLGLDVVVQEEEWGTGAKPEKIEEALRADKNHEIKAVMVVHNETATGVTSNIGAVRKAIDAAGHPALLFVDGVSSIGSLPFKADEWKVDCAIAGSQKGLMLPAGLGVICVSQKALKAAEGQSGRNDRLARVYFDWEDQKKQNPTGYFPYTPPLPLLYGLREALACLFEEGLENVYHRHAVLGEATRQAVAAWGLKTCAKSPEWNSDTVTAILAPEGVDAAKIIKHAYVRYNLALGAGLSQVAGKVFRIGHVGDLNELSLLGAIAGAEMSLIDNGVKVTPGSGVAAASSYLRENPLAKA
What are the official names of this protein?
Serine--glyoxylate aminotransferase, SGAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Protein: RNH2_EDWI9
Sequence: MSDIFVYPCAGRIAGVDEVGRGPLVGAVVTAAVILDPARPIAGLADSKKLSEKRRNALYDEIVEKALCWSLGRAEAEEIDRLNILQATMVAMQRAVAGLARQPDFVLIDGNRCPALPMAAQAVVKGDSRVAEISAASILAKVTRDREMAALDRQYPEYGFARHKGYPTALHLERLAALGATEHHRRSFGPVKRVLGL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1B_SULIM
Sequence: MTDVLVVLKVFPDSDEVNLDNLYTDISNKLPKEYRIIRKETEPIAFGLNALILYVQMPEQTEGGTDNLEEVVNNIQGVSHAEVVGITRLGF
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: BETB_BURO0
Sequence: MSVYGLQRLYIGGGYVDATSGKTFDTFDPATGELLAQVQQASAADVDRAVASAQEGQREWATMTAMQRSRILRRAVDLLRERNDELAAIETRDTGKPIGETLAVDIVTGADVIEYYAGLATAIEGLQVPLRAESFVYTRREPLGVCAGIGAWNYPIQIACWKTAPALAAGNAMVFKPSEVTPLTALKLAEIYTEAGVPAGVFNVVQGDGSVGALLTGHPDIAKVSFTGGVETGKKVMSLAGASSLKEVTMELGGKSPLIVFDDADLDRAADIAVTANFFSSGQVCTNGTRVFVHRSIKDAFTQKVLERVKRIRVGKPTDADTNFGPLVSAAQLDKVLGFIESGKAEGAKLLAGGTRLTDGHFGSGQYVAPTVFGDCRDDMKIVREEIFGPVMSILEFESEDEVIARANDTHYGLAAGVVTENLSRAHRTIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQVELGRYNPVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: WSB1_XENTR
Sequence: MASFPDFVNENEIARSRTIGELITPTSPFEQKYGRENWTVAFAPDGSYFAWSQGHRIVKLVPWSRCLKNFTACSTKNGVNLTNGRLSRQNSDLGQRNKPIEHTIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFKFGQDQLLLATGLSNGRIKIWDVYTGKLLLNLMDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYCCAFSPDSSMLCSVGAGKAVFLWDMDKYTMIRKLDGHYNDVVACEFSPDGALLATASYDTRVYVWDPHIGSILFEFGHLFPPPTPIFAGGDNGRWVKSVSFSHDGVHIASLADDNLVRFWRIDKSYPVEVAPLSKGLCCAFSTDGSVLAAGTQDGNAYFWSTPKYVSSLQHLCRMAIRRVMNTNEVKKLPIPQKIMEFLTYQTM
What is the function of this protein?
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
WD repeat and SOCS box-containing protein 1, WSB-1.
Protein: LIPA_EHRRW
Sequence: MKSKPDWLKVKMPTGSAFYEMRNLMKLHKLNTVCEEAACPNIGECWNKKHATVMILGSTCTRACAFCNVASGIPDKLDPHEPQSLAKAVSSLKLQHVVITSVDRDDLEDGGAGHFVECIEEIRKRDSNVTIEILTPDFLNKHDAIDKIAKAFPDVYNHNVETVPRLYAKIRPKARYFHSLYLLKTIKQKNPRIFTKSGIMVGLGELKEEIYQVMDDLRSADVDFIVIGQYLQPTSKHAVVDRYVTPEEFDHYKYVAYSKGFLMVASGPLVRSSYHAEEDFQRLKKNRAAMYT
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2B3_CHLRE
Sequence: MAPKKDEKPATAEAGAEAPAKAEAKPKAEKAGKKAKKEPAKKAAKEPKGDGEKKDKKKKKSAVETYKLYIYKVLKQVHPDTGISSKAMSIMNSFINDIFEKVATEASKLSRYNKKPTVTSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.3, H2B-III.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: GREA_OCEIH
Sequence: MTVEKSYYMTQEGKDKLEEELHYLKTDRRQEVVERIKVARDFGDLSENSEYDAAKDEQAFVEQRITQVEKMIRNAVIIENDNDNPNIVSLGKSVSFVELPDGDEETYTIVGSAEADPFEGKISNDSPMATSLLGKEIGEEVTVTTPGGDIDVRITNVE
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: CYPL8_GANLU
Sequence: MPDSSLVLVAIAGAAYIFWLVFHRYLVRSPLDNLPSPPSSPFLGNLPDIIHRQSHLWWRHVSNTYGPATKLTAFFGIQMLYTFDPKAMYSILVKDTELYPKKTAAYDDFTLFIGPGLLFAEGAQHRRQRKWLNPVFSVAQLRDVSHVFYGVAYKLEEAIRNRVGAQSQNLDVNGWMARTTLEMLGQAGLGYSFDKFTEDSTDSYGEALKSFFPVINHVPLLNLFVMTLANHIPKWLMRRVLRLAVPFPHVLRLLRISETMQKRSSEIIQQKKTALQKGDKALIHQVGEGKDIMSVLLKSNMNAPSDSEKLPDEELLAQMSTFILAGMDTTSNALSRILHLLAEHPDVQEKLRHELSEAREIVGNGKDVPYDDLVKLPYLDAVCRETLRLHPPLNLIGRRAAKDMVVPLSSPVRGRDGTLVNEVTLPKDTFVLLGLQACNTNKKLWGEDAYEWKPERWLQPLPSMLEEARVPGVYSNLMSFSGGVRSCIGFKFSQLEMKVLLTILLPAFSFELTEKPIFWNTSAVSYPTMDKDSTRPEMLLKVKALAC
What is the function of this protein?
Cytochrome P450 monoxygenase that is involved in the biosynthesis of ganoderic acids (GA), a group of highly oxygenated lanostane-type triterpenoids which well recognized as a main group of unique bioactive compounds in the medicinal mushroom Ganoderma lucidum (PubMed:29476632, PubMed:31449331, PubMed:31865439).  CYP5150L8 alone is able to catalyze the three-step oxidations at C-26 from lanosterol to 3-hydroxy-lanosta-8,24-dien-26-oic acid (also called ganoderic acid Z or HLDOA) (PubMed:29476632).  The methyl group of lanosterol at C-26 is first oxidized into hydroxyl group to form 3-hydroxy-lanosta-8,24-dien-26-ol (HLDO) (PubMed:29476632).  The hydroxyl group at C-26 of HLDO is further converted into a formyl group to form 3-hydroxy-lanosta-8,24-dien-26-al (HLDA) (PubMed:29476632).  Finally, the formyl group is oxidized into a carboxyl group to produce 3-hydroxy-lanosta-8,24-dien-26-oic acid (HLDOA) (PubMed:29476632).
What are the official names of this protein?
Ganoderic acid synthetase CYP5150L8, Cytochrome P450 monooxygenase CYP5150L8.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RRF_ECO7I
Sequence: MISDIRKDAEVRMDKCVEAFKTQISKIRTGRASPSLLDGIVVEYYGTPTPLRQLASVTVEDSRTLKINVFDRSMSPAVEKAIMASDLGLNPNSAGSDIRVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKEISEDDDRRSQDDVQKLTDAAIKKIEAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
Protein: SECB_XANOP
Sequence: MSDEILNGAAAPADAAAAGPAFTIEKIYVKDVSFESPNAPAVFNDANQPELQLNLNQKVQRLNDNAFEVVLAVTLTCTAGGKTAYVAEVQQAGVFGLVGLDPQAIDVLLGTQCPNILFPYVRTLVSDLIQAGGFPPFYLQPINFEALYAESVRQRHNESASLADSEPAGNA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_DICDI
Sequence: MSDNLKSYQDNHIENEDEEIYERSNGKGKELVDFGKKREPLIHNHEVLNTMQSSVKTLLSSLGEDPDREGLLKTPLRMSKALLFFTQGYEQSVDEVIGEAIFNENHHEMVVVRDIDIFSLCEHHMVPFHGKCHIGYIPDQKVLGLSKLARVAEIFARRLQVQERLTRQIAQAIQAHLNPMGVAVVIEASHMCMVMRGVQKPGASTVTSSVCGIFEKDSRTRAEFFSLIKSNK
What is the function of this protein?
First enzyme in the biosynthesis of tetrahydrobiopterin (BH4) (PubMed:8870645).  Catalyzes the conversion of GTP into dihydroneopterin triphosphate (7,8-dihydroneopterin 3'-triphosphate), which is subsequently catalyzed by 6-pyruvoyltetrahydropterin synthase (ptsA) and sepiapterin reductase (sprA) (PubMed:8870645).
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: PURR_ECOL6
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPQSWIVQGDFEPESGYRAMQQILSQSHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: RL10E_METMA
Sequence: MVRKPGSMYRNVRQRSFTRRKYMGGVPGSQVIHYDMGDKANTTFPVKISLVAEEKCQIRHTALEAARITANRHLVADAGKMGFYMKLRVYPHEVLRENKQATGAGADRVSSGMRRAFGKNVGTAARVNSMQKLFTVAVEKQNFPAAKKALWHAGQKLPTPVRIVIDEGAELVQ
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: SSUD_ECOLI
Sequence: MSLNMFWFLPTHGDGHYLGTEEGSRPVDHGYLQQIAQAADRLGYTGVLIPTGRSCEDAWLVAASMIPVTQRLKFLVALRPSVTSPTVAARQAATLDRLSNGRALFNLVTGSDPQELAGDGVFLDHSERYEASAEFTQVWRRLLQRETVDFNGKHIHVRGAKLLFPAIQQPYPPLYFGGSSDVAQELAAEQVDLYLTWGEPPELVKEKIEQVRAKAAAHGRKIRFGIRLHVIVRETNDEAWQAAERLISHLDDETIAKAQAAFARTDSVGQQRMAALHNGKRDNLEISPNLWAGVGLVRGGAGTALVGDGPTVAARINEYAALGIDSFVLSGYPHLEEAYRVGELLFPLLDVAIPEIPQPQPLNPQGEAVANDFIPRKVAQS
What is the function of this protein?
Involved in desulfonation of aliphatic sulfonates.  Catalyzes the conversion of pentanesulfonate to sulfite and pentaldehyde and is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase, Sulfate starvation-induced protein 6, SSI6.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: SYC_DESDA
Sequence: MLLYNTLGRQKEEFTPLRPGKVHMYVCGITAYDYCHIGHARSALVFDVLVRQLRHMGLDVTFVRNFTDVDDKIINRANKEGLDWREVAQTYINAFYEDMDRLGVQRADVEPRATDHIQEIQDLCAKLVAEGKAYATTSGDVYFRVRSYPPYGKLSGRSLDELLSGARVAPGEEKEDPLDFALWKAAKPGEPSWESPWGPGRPGWHIECSAMSESYLPLDIHGGGQDLVFPHHENEIAQTEAVCHCHLARYWVHNGFVQVNAEKMSKSLGNFKTIRDILESYLPETLRFFLLGKHYRSPIDFTAEGMDEAEKALHRVYTALLETQKALTREKWKKSPLPAQLTEDWAAQAEALDEAMNDDLNTAQALGHIFTQVRLVNRLLEDKTLRAAEAGRDLLQDFLARAEQWNTRLGLFGQQPEAFLADLRRIRAARRNIDIPRVEALLQERQEARANKDFARSDALRQALLDLGVSVQDTPEGQNWDLE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCKC_BACSU
Sequence: MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMFISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITFGLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE
What are the official names of this protein?
Uncharacterized protein YckC, ORF3.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KDPB2_LISIN
Sequence: MEKKAKPGFWDKKILGTAVKGAFIKLNPVYMVKNPVMFVVEIGAIISLALCFFPNLFGGNNQDMILYNSLVFIILLLTLLFANFSESVAEGRGKAQAASLKQTQQDMQARLILNGKEKVVNANTLKKGDIVLVNMGEVIPSDGEIIEGVASVDESAITGESAPVLKESGGDFASVTGGTTVASDYLKIQITSNPGESFIDKMIQLVEGASRKKTPNEIALSTLLVSLTIIFLIVIVSLYPMAIYTGIKLPVSTLVALTVCLIPTTIGGLLSAIGIAGMDRVTRFNVIALSGKAVEACGDVDTMILDKTGTITYGNRMASEFIALDKGNKNYLIHYAILASIQDNTPEGKSIVTLGKDLLKEDLDTNDIRENQFIEFTAQTRMSGVDLADGTRIRKGAYDAIIKYIKNIGGEIPHDLEDKVNNISKLGGTPLVVCAEEKIYGVIYLKDTIKPGLVERFERLRSIGIKTIMCTGDNPLTAATIAHEAGVDSFIAECKPEDKIKVIKDAQSKSKVVAMTGDGTNDAPALAQADVGIAMNSGTTAAKEAANMVDLDSDPTKILDVVEIGKQLLITRGALTTFSIANDIAKYFAIIPAMFLAIIPQMQVLNIMHLSSSYSAILSALIFNAIIIPCLIPLAMKGVKYKLQRSEKMLAHNMLVYGVGGMIVPFIGIKLIDLVIAPLLTMMGLG
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit 2, ATP phosphohydrolase [potassium-transporting] B chain 2, Potassium-binding and translocating subunit B 2, Potassium-translocating ATPase B chain 2.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 4HYPE_BURTA
Sequence: MKHLHIIDSHTGGEPTRVVVSGFPPLGDGPMAERLAALARDHDRYRTACILEPRGSDVLVGALLCEPVSAGAAAGVIFFNNAGYLGMCGHGTIGLVRTLHHMGRIAPGVHRIETPVGDVEATLHDDLSVSVRNVLAYRHAKDVVVEVPGHGSVTGDVAWGGNWFFLVSDHGQRIAGENVAALAAYASAVRAGLERAGVTGRDGAPIDHIELFADDPEHDSRSFVLCPGHAYDRSPCGTGTSAKLACLAADGKLAPGAAWRQASVIGSVFSASYERAESGVVPTIRGSAHLSAEATLLIEDDDPFGWGIVS
What is the function of this protein?
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp).  Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate.  Can also catalyze the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C), albeit with 42-fold lower efficiency.  Displays no proline racemase activity.
What are the official names of this protein?
4-hydroxyproline 2-epimerase, 4Hyp 2-epimerase, 4HypE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.