PharMolix/UniProtQA huggingface dataset:
Protein: RSD_ECO24
Sequence: MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD4_MOUSE
Sequence: MASKLLRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTGTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQHWLLDGFPRTLVQAEALDGICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVQGIDDITGEPLVQQEDDKPEAVAARLRRYKDAAKPVIELYKSRGVLHQFSGTETNRIWPYVYTLFSNKITPIQSKEAY
What is the function of this protein?
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity).  Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity).  Also displays broad nucleoside diphosphate kinase activity (By similarity).  Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity).  Plays a protective role in the cellular response to oxidative stress (By similarity).
What are the official names of this protein?
Adenylate kinase 4, mitochondrial, AK 4, Adenylate kinase 3-like, Adenylate kinase isoenzyme 4, GTP:AMP phosphotransferase AK4.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: DAPF_BACAN
Sequence: MSQFSFTKMHGLGNSYIYVNMFEEQIPEEDLALVAEKVSNINTGIGADGMILICPSDVAPVKMRMFNNDGSEGKSCGNGLRCVAKYAYEHKLVEDTVFTIETLAGIVTAEVTVEEGKVTLAKIDMGAPRLTRAEIPMLGEGETPFIRENFLYNNHRYAFTAVSMGNPHAVIFVDDVEQAPLTTLGPVLETHEMFPERVNVEFIEILNEEEMNFRVWERGSGVTQACGTGACAAVVASILNGKMERGKEITVHLAGGDLMIAWTEEGNVLMKGPAEVICRGVYEYKIEA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBD_YERPP
Sequence: MAQRFITLILLLCSVLLAPHSAQSSLFGENASFGTKNSQSRFIPVDQAFAFDFHQQGDQLNLSWQIHPGYYLYRQQIKIVPQQAALGAFTLPEGITHHDEFYGEVEIFKQQLTLKIPITQAAEQASVSVTYQGCAEAGFCYPPETRVIPLDVVVAASTASGTAAVNSSATVNPPATTQPEGDATPVPSTLPFSPLWALLIGIGIAFTPCVLPMYPLISAVILGREKPHSQRRILILAVVYVQGMALTYTLLGLVVAAAGLQFQAALQHPYVLIGLSVLFVLLALSMFGLYSLQLPSSLQTRLTQWSNSQRGGSLAGVFAMGALAGLICSPCTTAPLSAILLYIAQSGNMLAGGGTLYLYALGMGIPLVVVTLFGNKLIPRSGPWMQYVKEAFGFVILALPVFLLERVLGDVWGLRLWSLLAVAFFGWAFVLSLKAHAGWVRVCQLLLLAALLIVARPLQDWAFNGNTQQNAVKHINFQPVANLPQLQAVLAQAQGKPVMLDLYADWCVACKEFEKYTFSDDKVQRQLANTLLLQADVTANNAEHATLLKKFNVLGLPTILFFDSQGNEITAARVTGFMDAAQFLQHLQNTPAVTK
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL4_CHLTB
Sequence: MVLLSKFDFSGKELGKFELPDAFFTEGREQSVKDYLVAIQANKRQWSACTRGRSEVSHSTKKPFRQKGTGNARQGCLAAPQFRGGGIVFGPKPKFDQHIRINKKERRAAIRLLLAQKIQTGKLIVAENSVFVSSLDAPKTKEALRFLKECNVECRGVLFVDSLAHVGSNENLRLSVRNLSAVRGFTYGENISGYDIAAARNIVVSEKALELLVESLVSTTKD
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MINE_NEIMB
Sequence: MSLIEFLFGRKQKTATVARDRLQIIIAQERAQEGQAPDYLPTLRKELMEVLSKYVNVSLDNIRISQEKQDGMDVLELNITLPEQKKV
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity).
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: DEF_STRR6
Sequence: MSAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEAYDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRIKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: CREB_ASPCL
Sequence: MGSFLRSFRNNAGSTTPSVGAVPAKKEVPIPPMTPLEKRLLDMGSIRGDGSDKFYGMENYGNTCYCNSILQCLYYSVPFREAVINYPTRTPIESLEAALAKSLRYPNPNAHLEAEAQAEKQRAANAQRPGMPPAQPQKPEDKDSPDYKKKMALQTLPLLEAQNNATSYGMSESLFTSLKDIFESVVGSQSRIGIVRPQQFLDVLRRDHEMFRTAMHQDAHEFLNLLLNEVVANVEAEASKQPAAIEKSLPAPDHAETVDQSASSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEIFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVAIIKTEDRGWLLFDDELVEPVDKNYVRNFFGDKPGLACAYVLFYQETTLEAVMKEQEQENMESNLSATDTNEAALKPNGSSPSHLAHVHSASYIPSLEEHNRPNGLKRAPTAPQLSTHHEHGDPESGAFSPVTATPPVPPIPEHLSAAPIPPKSDVQGKKERAREEKERKAAEKEREKAEKLRRKEQEARAKENQRREEAELKAALEASKASKAQEDRRQSPDHGKDKLGGGLSRLKRGSKSFSQRLGKDKETRSVSSLEAPPLPIPGHPISRDGPIPEQHQQQPDPKDDPFQDSHHPNKPMMKEDEQANHKDPKHERTGHGKWRSFSLRKKSFSILS
What is the function of this protein?
Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  Deubiquitinates the creA catabolic repressor and the quinate permease qutD.  Also plays a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).
What are the official names of this protein?
Probable ubiquitin carboxyl-terminal hydrolase creB, Carbon catabolite repression protein B, Deubiquitinating enzyme creB, Ubiquitin thioesterase creB, Ubiquitin-hydrolyzing enzyme creB, Ubiquitin-specific-processing protease creB.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: THIG_PSESM
Sequence: MSDVRSDKPFVLAGRTFESRLLVGTGKYIDMEQTRLAIEASGAEIVTVAVRRTNLGQNPGEPNLLDVLPPDRYTILPNTAGCFDAVEAVRTCRLSRELLDGRNLVKLEVLADQKTLFPNVIETLKAAEILVKDGFDVMVYTSDDPIIARQLAEIGCIAIMPLAGLIGSGLGICNPYNLQIILEETKVPVLVDAGVGTASDATIAMELGCEAVLMNSAIAHAQQPVMMAEAMKHAVIAGRLAYLAGRMPRKLYASASSPLDGLIK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_ANAMF
Sequence: MLEQARRRLAGLNAKLRHHDMLYHGLDAPEVTDHQYDLLVQEKKRLLDEFPDIRQYDDYADVVGTPKIDSRFPKVQHLEPMLSLENAFTVQDVEKFITRVRRFLELQPDDILELSCELKMDGMSFSALYHGGKLTRVATRGNGHFGEDITTNAMVLRGLPHQLDSAPEVLEVRGEIYMHHEDFEKLRGSCNFANPRNAAAGSIRQLNQKIVEERNLSYVAYSAVNSTFATQQEILKQLDEWGFHTNKQVLFTDKIEEAIAFYNSVYTTRSALGYDIDGVVYKVNSINFQKLLGATGKSPRWAIAHKFPSTEARTKLLDITVQVGRTGVVTPIAELEPINIGGVMVSRASLHNLNEIERKDVRIGDLVIVKRAGEVIPQVVDVDKTLRSSGTQKFVFPSHCPSCGSKLHREPGEVALRCVAELSCKAQALERVKHFVSRDGLNIMGLGAKQIEFFCNHGLIGSIADIFSLEEKLHGINLDTEHGWGEKSVANLIAAIRNSATVRLSNFIFALGIRFIGVGAAKLIAEHYRSYKNWHQAMLALTETHDTVQIRGLGEKSISSLKAFFSVQGNLEVLESLSAKLNILDEASPAQRGSSAISGKTVVFTGTLESMSRTEAKLQAESLGAKVANSVSANTWLLVAGSNPGSKHEKALSLNVRVIDEQTWVKMVEDARS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DGTL1_RICPR
Sequence: MLASYASDPLKSRGRLYKEIPTYYRNEFERDRDRIIHTNAFRRLQYKTQVFINHEGDHYRNRLTHSLEVSTVARSVANTLNLSSDLAETIALAHDLGHTPFGHAGERALNECMKEYHGFSHNSQSLKILTLLEKRYAAYNGVNLTWEVLEGIVKHNGPILGAINEYVAEYNKQNDLELSTYASAEAQVASLADDISYISHDLEDSIGAKIIDFDSLAELQYIDNYVFELKAKFKDISPSCLIYEVVRKLIHELITDLLWQTKENLNKEKITNIDEIRNLHYPIVDFTEKTNERINEIKKFLHKRVYESNKMIAISIKCTKIVQGLFKIYMDDINLLPTNWKILIDSNKTYSKARVIADYIAGMTDRFAIQEYNQLCSPNFNNI
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: CSGB_ECO57
Sequence: MKNKLLFMMLTILGAPGIAAAAGYDLANSEYNFAVNELSKSSFNQAAIIGQAGTNNSAQLRQGGSKLLAVVAQEGSSNRAKIDQTGDYNLAYIDQAGSANDASISQGAYGNTAMIIQKGSGNKANITQYGTQKTAIVVQRQSQMAIRVTQR
What is the function of this protein?
Curlin is the structural subunit of the curli.  Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius.  Curli can bind to fibronectin.  The minor subunit is the nucleation component of curlin monomers (By similarity).
What are the official names of this protein?
Minor curlin subunit.
What is the protein family that this protein belongs to?
Belongs to the CsgA/CsgB family.
What are the subcellular locations of this protein?
Fimbrium. Note=Part of the curli surface structure.
Protein: BIR7A_XENLA
Sequence: MSRWSVSQGCGNSHKALTMAGHGEQLFRGWGMVRPSMRSEAERLRSFSAWPRTCPQPSPVEMARSGFYYLGPGDRVQCFSCGGVLRSWEPGDRPDTEHRKFFPSCTFLQQQQRDPGATDSQILGQHSGEEPDRTWESVYPEMAEERDRLDSFRNWPMYAHGNPEHLAGSGFFYTGHRDNVKCFHCDGGLRNWEQGDDPWTEHAKWFPMCDFLLHVKGEAFIRRVQESLFRSPESSPDSLGSYIYDRSPASSPGSPESWRYLQSSVAQDALQMGFKQSLVASLIQSKFLLTGSSYSSVSDLVTDLLVAEEETHSTESVSVSRAPTRMERSEPPKESAPPLSTEEQLRRLKEERMCKVCMDKDVSMLFVPCGHLVVCTECAPNLRHCPICRAAIRGSVRAFMS
What is the function of this protein?
Weak apoptotic suppressor.  Has E3 ubiquitin-protein ligase activity.  Weak inhibitor of caspase activity.
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 7-A, E3 ubiquitin-protein ligase EIAP-A, Embryonic/Egg IAP, xEIAP/XLX, Inhibitor of apoptosis-like protein, IAP-like protein, RING-type E3 ubiquitin transferase EIAP-A, XIAP homolog XLX, XLX.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRGA_STAAT
Sequence: MVVKQQKDASKPAHFFHQVIVIALVLFVSKIIESFMPIPMPASVIGLVLLFVLLCTGAVKLGEVEKVGTTLTNNIGLLFVPAGISVVNSLGVISQAPFLIIGLIIVSTILLLICTGYVTQIIMKVTSRSKGDKVTKKIKIEEAQAHD
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB.  The LrgAB and CidAB proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgA.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. LrgA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CIPKQ_ORYSJ
Sequence: MDDRRTILMDRYEIGRQLGQGNFAKVYYARNLTSGQAVAIKMIDKEKVTRVGLMVQIKREISIMRLVKHPNILQLFEVMASKSKIYFVLEYAKGGELFKKISKGKFSEDVARRYFHQLISGIDYCHSRGVYHRDLKPENLLLDENESLKVSDFGLSALSESKRHDGLLHTTCGTPAYVAPEVLSRRGYDGAKADIWSCGVILFVLVSGYLPFHDTNLIEMYRKIAKAEYKCPRSFSAELKDLLYKILDPDPSTRISIPKIKRSAWYRKSSDVNALKSKHETGDKVYKGEATTSDTTECSIFEGNRASSRDKVYTNGEATTSDSPECSNSDGKQASLSLPNLNAFDIISLSTGFDLSNLFEERYGRREERFTTRQPAAAIFAKLNELARRFKLKIKKKENGVLRLVAPKEGIKGLLELDAEVFELAPSFHLVEFKKSNGDTIEYQKLMKEDIRPALKDIVWAWQGGQHQQPEQSMQGMQGEQQPSRLPSQQPQG
What is the function of this protein?
CIPK serine-threonine protein kinases interact with CBL proteins.  Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).
What are the official names of this protein?
CBL-interacting protein kinase 26, OsCIPK26.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Protein: GAS6_MOUSE
Sequence: MPPPPGPAAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQECMRKYGRPEEKNPDFAKCVQNLPDQCTPNPCDKKGTHICQDLMGNFFCVCTDGWGGRLCDKDVNECVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQTCQDIDECTDSDTCGDARCKNLPGSYSCLCDEGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCDGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLERGLYHLNLTVGGIPFKESELVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFATYRLNYTRTSLDVGTETTWEVKVVARIRPATDTGVLLALVGDDDVVPISVALVDYHSTKKLKKQLVVLAVEDVALALMEIKVCDSQEHTVTVSLREGEATLEVDGTKGQSEVSTAQLQERLDTLKTHLQGSVHTYVGGLPEVSVISAPVTAFYRGCMTLEVNGKILDLDTASYKHSDITSHSCPPVEHATP
What is the function of this protein?
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration.  GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
What are the official names of this protein?
Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand.
What are the subcellular locations of this protein?
Secreted.
Protein: TDRD7_AILME
Sequence: MLEADLVSKMLRAVLQSHKNGIALPRLQGEYRSLTGDWIPFKQLGYPTLEAYLRSVPAVVRIETSRSGEITCYAMACTETARIAQLVARQRSSKRKTGRQVNCQMRVKKTMPFFLEGKPKATLRQPGISSDFSINKKPNPTLLRDRGNSLGVKSDAEMPPYTLHTTIGSQVFKDVPVQRHVTMSTNNRFSPKASLPPPFQMHLSRTCAKEMSDNLNQTVEKPNVTPPASYTYKMDEVQNRIKEILNKHNNGIWISKLPHFYKELYKEELNQGILQQFEHWPHICTVEKPCSGGQDLLLYPAKRKQLLRSELDGEKVPPSPLPAPKQLPPLKGCPAAMPGDFKEKVAELLAKYSSGLWASALPKAFEDMYKVKFPEDALKNLASLSDVCTIDYISGNPQKAILYAKLPLPADKILKDAGQAHGDYDIKSMIEQEYLQIEENISKSADTFVENTTVPPLIIPTEASPSVLVVELSNTNEVVIRYVGKDYSAAQELMEDEMKEYYSKNPKVMPVQTVHIGQLLAVNAEEDAWLRAQIISTEENKIKASTVCYVDYGFSENIEKSKAYKLNPKFCSLSFQATKCKLAGLEVLSDDPDLVKVVESLTCGKIFAVEILEKADIPLVVLYDTSGEDDVNINATCLKAICDKSLEAHLQIDAMYTNVRVTNICSDGTLYCQVPCKGLNKLNDLLHKIEDYFHCKHMTSEYFVSLPFCGKVCLFHCKGKWLRVEITNVHSSRALDVQFLDSGTVTSVKVSELREIPPRFLQEIIVIPPQAIKCCLADLPQSIGMWTPDAVLWLRDSVLNCSDCSIKVTKVDETRGIAHIYLFTPKNFPDPHRSINRQITNADLWKHQKDVFLSAISSAASSPNSKSGGTPIPGNSGENFRKSITDAIKKSVVDHSSSFSMQELPPPVHLSKPGEHMDVYVPVACHPGYFVIQPWQEIHKLEVLMEEMILYYSVSEERHVAVEKDQVYAAKVENKWHRVLLKGILTNGLVSVYELDYGKHELVNIRKVQPLADVFRKLPFQAVTAQLAGVKCNQWSEEASMVFRNHVEKKPLVALVQTVIENANPWDRKVVVYLVDTSLPDTDIWIHDFMSEYLVELSKVN
What is the function of this protein?
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation.  Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens.  Also required during spermatogenesis (By similarity).
What are the official names of this protein?
Tudor domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the TDRD7 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cytoplasmic RNA granules (By similarity). Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity).
Protein: SRTD3_HUMAN
Sequence: MVGGLKRKHSDLEEEEERWEWSPAGLQSYQQALLRISLDKVQRSLGPRAPSLRRHVLIHNTLQQLQAALRLAPAPALPPEPLFLGEEDFSLSATIGSILRELDTSMDGTEPPQNPVTPLGLQNEVPPQPDPVFLEALSSRYLGDSGLDDFFLDIDTSAVEKEPARAPPEPPHNLFCAPGSWEWNELDHIMEIILGS
What is the function of this protein?
Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (PubMed:33147462, PubMed:36594413).  Plays a role in the late phase response of TLR-induced immune effector expression (By similarity).  During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex (PubMed:33147462).  Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation (PubMed:36594413).  Strong transcriptional coactivator (PubMed:10982866).
What are the official names of this protein?
SERTA domain-containing protein 3, Replication protein-binding trans-activator, RPA-binding trans-activator.
What are the subcellular locations of this protein?
Nucleus.
Protein: SRA4_CAEEL
Sequence: MSLTKCASKLEIDRLISLNFRINQIIVLIPVFITFIFTYYAIKVVQKKSIFELSTKFLLIQNFFSANLHQVLYAIETIRRLHISLFETNQPCIPLKTEFECRLYLEVFVSGVAGMVYGQTGLLLERACATFIKNYEEKKSVRTGLAISVSVLCLSFITSRLIIWDDPLDGYQLTCISFPSDSVDRSSYFQSICTLLALFNLVTSILIWKYNKKFEYSTPFVVGPRFRKREVIDSTSTICFLTFVQFIFFLVYSLGFFIIKSIREIISYENYYLVAVWLYTPPYIAASFPILIFYRIRSSYANRVLIIKKFTNTKQTIEEHIQQMKNAWK
What are the official names of this protein?
Serpentine receptor class alpha-4, Protein sra-4.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein sra family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: COXX_ALKPO
Sequence: MNKSNTAIDPTNVIEAGPDSSVADVQQKSWKDYLVLAKQGIVTSNLITTFAGIYLAIVYTGTVFTMHLDTMIFALLGAALVMAGGCTLNNYIDRDIDHLMERTKERPTVTGRFSAKHVLLVGLAQAALGIIFLALTTPTAAVIGLIGLFIYVVLYTMWTKRTTTLNTIVGSFSGAVPPLIGWAAIDGGLHLYAWLLFFIMFLWQPPHFLALAMKRVEEYRAAGIPMLPVVAGFEMTKRQMVVYVAALLPVSLMLYPFGLVYTIVAAVLGVGWLALGIAGFKMKDDIKWARLMFVYSLNYLTILFVLMVIVHF
What is the function of this protein?
Converts protoheme IX and farnesyl diphosphate to heme O.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: XGPT_ECODH
Sequence: MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMGVVFVPPISGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PRRX2_MOUSE
Sequence: MDSAAAAFALDPPAPGPGPPPAPGDCAQARKNFSVSHLLDLEEVAAAGRRAAGPVSGPAEARVGAAREPSGGSSGTEAAPQDGDCPSPGRGTKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLATRSASLLKSYGQEAAIEQPVAPRPTTMSPDYLSWPASSPYSSVPPYSPGGSSPATPGVNMANSIASLRLKAKEFSLHHSQVPTVN
What are the official names of this protein?
Paired mesoderm homeobox protein 2, PRX-2, Homeobox protein S8.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATP8_AILFU
Sequence: MPQLDTSTWSITITSVVLTLFIMFQLKILKSSFPNNPEPKSTPMLKTSMPWEKKWTKIYLPLSLPQH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: PYM_ARATH
Sequence: MPEARDRIERQVDYPAAFLNRRSHGILLDEPATQHNLFGSPVQRVPSEATGGLGSIGQGSMTGRGGLVRGNFGIRRTGGGRRGQIQFRSPQGRENMSLGVTRRGRARASNSVLPSWYPRTPLRDISAVVRAIERRRARMGEGVGRDIETPTPQQLGVLDSLVPLSGAHLEHDYSMVTPGPSIGFKRPWPPSTAKVHQILLDITRENTGEEDALTPEKKLLNSIDKVEKVVMEEIQKMKSTPSAKRAEREKRVRTLMSMR
What is the function of this protein?
Negative regulator of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase required for proper mitotic progression and cell fate determination; inhibits premature cell differentiation.  Prevents DNA endoreplication by promoting the maintenance of the mitotic state by preferentially inhibiting APC/C(FZR) and triggering cyclins accumulation (e. g.  CYCB1-1, CYCB1-2 and CYCA2-3) in a temporal manner.  Required for megagametophyte and endosperm development.  Counteracts the activity of CCS52A1 thus inhibiting the turnover of CYCA2-3.  Confers immunity to bacterial pathogens (e. g.  Pseudomonas syringae pv.  tomato DC3000), which is associated with increased expression of disease resistance (R) genes.
What are the official names of this protein?
Protein POLYCHOME, Protein UV-B-INSENSITIVE 4.
What are the subcellular locations of this protein?
Nucleus. Note=Follows a patchy nuclear accumulation pattern.