PharMolix/UniProtQA huggingface dataset:
Protein: MTO_HYPSQ
Sequence: MKKHLLAGACALAMGFAVIPGTFADETCNSPFTTALITGQEQYLHVWTLGMPGVGDESDKLVTISVDPKSDKYGKVINTLSVGGRGEAHHTGFTDDRRYLWAGRLDDNKIFIFDLIDPANPKLIKTITDFADRTGYVGPHTFYALPGRMLIQALSNTKTHDGQTGLAVYSNAGELVSLHPMPVTDGGDGYGYDIGINPAKNVLLTSSFTGWNNYMMDLGKMVKDPEAMKRFGNTMAIWDLKSMKAEKILNVPGAPLEIRWSLKPEHNWAYTATALTSKLWLIKQDDKGEWIAKETGTIGDPSKIPLPVDISITADAKGLWVNTFLDGTTRFYDISEPEHPKEVFSKKMGNQVNMVSQSYDGKRVYFTTSLIANWDKKGAENDQWLKAYDWDGKELVEKFTVDFNELKLGRAHHMKFSSKTNAAELGTNQSFPTRQ
What is the function of this protein?
Catalyzes the oxidation of methanethiol.  Can also degrade ethanethiol, but not methanol, methylamine or dimethylsulfide.
What are the official names of this protein?
Methanethiol oxidase, MTO.
What is the protein family that this protein belongs to?
Belongs to the selenium-binding protein family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYGA_COXB2
Sequence: MKSSHPVNFQQMILALQEYWASQGCVLLQPFDMEVGAGTFHPATFLRAIGPEPWRAAYVQPSRRPTDGRYGDNPNRTQHYYQFQVVLKPSPDDIQDIYLGSLKALGIDPLTHDIRFVEDNWEAPTLGSWGVGWEVWQDGMEITQFTYFQQIGGLECKPVTGEITYGLERLAMFLQGIDNMFDLVWTEGPNGRVTYGQIFQQNEVEMSAYNFEYANVEALFNFFDFYEKEASQLIEVHLPLAAYEMVLKASHTFNLLDARQAISVTERQRFILRVRKLAQAVAEAYYSAREKLGFPMLEEISSSSSRVLPLAGNDRVKGC
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_BURCJ
Sequence: MTELFIDGAWVAGSGPVFASRNPGTDAVAWQGDSASAADVDRAVASARRAFAGWSALDFEARCEIVKRFAALLTERKEAIATAIGRETGKPLWEARTEVASMAAKVGISIQAYQERTGEKRQDMADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAPGVARATVEVWQAAGLPPGVLNLVQGEKDTGIALANHRQIDGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVIGEVEDVDAAVHHTIQSAFLSAGQRCTCARRIFVPQGAFGDRFLARFADVTSKITADVFDADPQPFMGAVISARAAAKLVDAQSRLVEQGAKPIIAMTQRDPRLGFVNAAIADVTGVANLPDEEHFGPLAQVVRYTTLDDAIERANDTAFGLSAGLLADDPKVWEHFRRTIRAGIVNWNRPTNGASSAAPFGGTGRSGNHRPSAYYAADYCAYPMASVESTQLTLPASLSPGLHF
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: PLIAB_BOTNU
Sequence: MRLILLSGLLLLGIFLANGDEVDPDRKLLNSLIDALMHLQREFANLKGSFLIVHKARSFGSGSERMYVTNKEIKNFEALRQICEQADGHIPSPQLENQNKAFANVLERHGKEAYLVVGDSANFTNWAAGEPNKAAGACVKADTHGSWHSASCDDNLLVVCEFYFIL
What is the function of this protein?
This phospholipase A2 inhibitor binds directly phospholipase A2 in the presence or absence of calcium.
What are the official names of this protein?
Phospholipase A2 inhibitor clone 11, alpha-PLI.
What is the protein family that this protein belongs to?
Belongs to the alpha-type phospholipase A2 inhibitor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in plasma.
Protein: PRPE_BACVZ
Sequence: MAYDIISDIHGCYDEMIALMQKLGYEVKDGTPVHSEDRTLVFAGDLTDRGPKSVEVMRFVAKAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAELKELSPADRTEVSRQFIRLYESAPLYDILHNGDLVVAHAGIKADDIGKYSRKVKEFVLYGDITGETHPDGRPVRRDWAAAYEGKAWIVYGHTPVKRPRIVNRTINIDTGCVFGNQLTGFRFPEHETVSVESSMPYDASRFREDHGRQA
What is the function of this protein?
Asymmetrically hydrolyzes Ap4p to yield AMP and ATP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical], Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the PrpE family.
Protein: S26A3_HUMAN
Sequence: MIEPFGNQYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGKIDFTINTNGGLRNRVYEVPVETKF
What is the function of this protein?
Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094).  Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
What are the official names of this protein?
Chloride anion exchanger, Down-regulated in adenoma, Protein DRA, Solute carrier family 26 member 3.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity).
Protein: ITS3_SCHPO
Sequence: MKIDSNGIVNPHSITNEIPSYDEKQAVDLNGNAFAPNGTFQKKDLISHKNDFERTMRHDVLHTNPKIEVRSETHIYEPNDSLFKENQDFPSNPTAHSPSSSSNDSVITATGVPDGILRDSPIVSALEPPSSNSSSSPQLQNLKHQLSSPQPSRAPIDRSSSNPVTSSQQPPNDRSTLSSSQKAKRPLKRSYSEKNSSNAEPSGSRSGDRGTNVSTSGSLLDGIPPDIGSASWAEAVKQKRVNMRRRREELDDECVLVGTRVSEGHENYVTAYNMLTGIRVGVSRCQAKMDRELTPADFTARHKFTFDITGNELTPSAKYDFKFKDYAPWVFRHLRQLFHLDAADYLVSLTSKYILSELDSPGKSGSFFYFSRDYRFIIKTIHHSEHKFLREILYDYYEHVKNNPNTLISQFYGLHRVKLPFGRKIHFVVMNNLFPPHRDIHQTFDLKGSTLGRELDENQPCQSPMCTMKDTNWIRRNMHLQFGPLKRQIFLTQVKADIDMLSSLGIMDYSLLVGIHDLSRGNRDKIRNSILSVYDPNVSQHRVPSINGNESHSNVHVIRQVVNSTGPVSLDQSCNLLPTDQFVERRNFMFYSDDGGFQATDENNEPGNFIFYIGIIDLLTKYSYVKRVEHLWKGINHSDSVISAVPPAEYASRFYKFVESSIKPTLLVLKPFPLKPQDGQRVNKQQSVNAGNVRTNNKHGSLNNNTAPSSRNAKSTSAHKSPKTEHRFPFPCRNVTTNTSSS
What is the function of this protein?
Involved, together with the calcineurin ppb1, in cytokinesis.
What are the official names of this protein?
Phosphatidylinositol 4-phosphate 5-kinase its3, 1-phosphatidylinositol 4-phosphate kinase, Diphosphoinositide kinase, PIP5K, PtdIns(4)P-5-kinase.
What are the subcellular locations of this protein?
Nucleus. Membrane; Peripheral membrane protein. Note=The active form of the enzyme is membrane-associated and concentrates at the septum in dividing cells.
Protein: RL3_CUTAK
Sequence: MTNERTVKGVLGTKLGMTQLWDEHNRLVPVTVIQAGPCVVTQVRTPETDGYSAVQLGYGAVKAKNVTKPEAGHFEKAGVTPRRHLVELRTADASEYTLGQEIAADVFSESDFVDVTGTSKGKGTAGVMKRHGFGGLRATHGVHRKHRSPGSIGGCSTPGKVIKGLRMAGRMGVERVTVQNLQVHSVDAERGIMLVRGAVPGPKGSLLVVRSAAKKAAKNGDAA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RL332_STRAW
Sequence: MAATDVRPKITLACVECKERNYITKKNRRNNPDRLEMKKHCPRCNAHTAHRETR
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: APT_BREBN
Sequence: MDFKQYIRVIPDFPQPGIRFKDITTLLKDGPAYKAAIQDLAVFAREVQADVIAGPEARGFVVGAPLSYEMGIGFVPIRKSGKLPYESIKANYDLEYGKDALAVHVDAIQPGQRVLIADDLLATGGTIETTINLIEQLGGKVVGAAFFIELSYLDGRSKIGEIPIKSLVQY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_PECCP
Sequence: MLHIADTTLTSRLLTGTGKFATPELMLAALEASGSQLVTMAMKRVDLNGGNDAILAPLRQLGIKLLPNTSGAKTADEAIFAARLAREALGTHWLKLEIHPDVKYLLPDPIETLKAAEQLVKEGFTVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLQTRDFLRIIIEQARVPVIVDAGIGAPSQAADALEMGADAVLVNTAIAVARDPVAMARAFRLAVEAGGLARQAGLGSKQFVASATSPLTGFLHQQAEGAVR
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_SHEB8
Sequence: MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVENGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTDISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVMTGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGLYEELSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEAGFLSMAHGEEEMRLTLEAADRVLASMKAAS
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_PROA2
Sequence: MLVKTRGVILKEIKFRDQSKICPVFTEHFGKISVILKGVRNPKNKLSGVFSTGNMVELVIYKKQNRDLHLVSDALLLQSPMSARPDMERFTTIYQLIETLKQVTGSEEPHPVLFRFLAATIEELCKPERDYQLVLAWFLIRLVTVLGFEPELEQCVISGEPLIPAAEAMAPDENLYFLFDPGGIAFAGPSALIRSEKRALPALSFRLLRWLSRQNIDALPDIRIPEEHPRRLCELLQDYCAVHIDHNPPVRNRRIISQIRPDNT
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: TILS_SHIFL
Sequence: MTLTLNRQLLTSRQILVAFSGGLDSTVLLHQLVQWRTENPGVTLRAIHVHHGLSANADAWVTHCENVCQQWQVPLVVERVQLAQEGLGIEAQARQARYQAFARTLLPGEVLVTAQHLDDQCETFLLALKRGSGPAGLSAMAEVSEFAGTRLIRPLLARTRGELEQWALAHGLRWIEDESNQDDSYDRNFLRLRVVPLLQQRWPHFAEATARSATLCAEQESLLDELLADDLAHCQTSQGTLQIAPMLAMSDARRAAIIRRWLAGQNAPMPSRDALVRIWQEVALAREDASPCLRLGAFEIRRYQSQLWWIKSITGQSETIVLWQTWLQPLELPAGLGTVQLTAGGDIRPPRADEAVSVRFKAPGLLHIVGRNGGRKLKKIWQELGVPPWLRDTTPLLFYGETLIAAAGVFVTQEGVAEGENGVSFVWQKTLS
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_ACTPJ
Sequence: MKTFVAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVINAEKVAVTGKKETDKIYYWHTGYVGGIKDATFKEMIARRPEAVIEIAVKGMLPKGPLGREMFRKLKVYAGNEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RL27_STAAC
Sequence: MLKLNLQFFASKKGVSSTKNGRDSESKRLGAKRADGQFVTGGSILYRQRGTKIYPGENVGRGGDDTLFAKIDGVVKFERKGRDKKQVSVYAVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: HEM1_RHIRD
Sequence: MDFEAFFTTELQSLHSEGRYRVFADIERQQGNFPRATRYNANGQRKDVTVWCSNDYLGMGQNPKVIEAMKAAIDHCGAGAGGTRNISGTNHYHVLLEQELADLHGKESALIFTSGYVSNWATLGTLGQKIPGLIIFSDALNHASMIEGIRYGRCERVIWKHNDLEDLEAKLKAADPNAPKLIAFESVYSMDGDIAPIKEICDLADRYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLTIIEGTLGKAFGVMGGYITGSTAVCDFIRSFASGFIFTTALPPSLAAGAIASIQHLKASPFERARHQDRVRKLRGLLDARGIPHMDNPSHIVPVMVGDAAKCKWISDILLDSHGVYVQPINYPTVPRKTERLRITPTPLHSDADIEHLVGALHQLWSHCALARAVA
What are the official names of this protein?
5-aminolevulinate synthase, 5-aminolevulinic acid synthase, Delta-ALA synthase, Delta-aminolevulinate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: GATA_FUSNN
Sequence: MVYNNLYELTAKELRDKFLSNELSAEEIVNSFYERIEKVEDKIKSFVSLRKDKALDEARKLDEKRKNGEKLGRLAGIPIAIKDNILMEGQKSTSCSKILENYIGIYDATVVKKLKEEDAIIIGITNMDEFAMGSTTKTSFHHKTSNPWDLNRVPGGSSGGAAASVAAQEVPISLGSDTGGSVRQPASFCGVVGFKPTYGRVSRYGLMAFASSLDQIGTLAKTVEDIAICMNVIAGVDDYDATVSKKEVPDYTEFLNKDIKGLKIGLPKEYFIEGLNPEIKNVVDNSVKALKELGAEVVEISLPHTKYAVPTYYVLAPAEASSNLARFDGIRYGYRAKDYTDLESLYVKTRSEGFGAEVKRRIMIGTYVLSAGFYDAYFKKAQKVRTLIKQDFENVLNEVDVILTPVAPSVAFKLSDTKTPIELYLEDIFTISANLAGVPAISLPGGLVDNLPVGVQFMGKPFDEEILIKIADALEKKIGRLNLPKLD
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RL1D1_HUMAN
Sequence: MEDSASASLSSAAATGTSTSTPAAPTARKQLDKEQVRKAVDALLTHCKSRKNNYGLLLNENESLFLMVVLWKIPSKELRVRLTLPHSIRSDSEDICLFTKDEPNSTPEKTEQFYRKLLNKHGIKTVSQIISLQTLKKEYKSYEAKLRLLSSFDFFLTDARIRRLLPSLIGRHFYQRKKVPVSVNLLSKNLSREINDCIGGTVLNISKSGSCSAIRIGHVGMQIEHIIENIVAVTKGLSEKLPEKWESVKLLFVKTEKSAALPIFSSFVSNWDEATKRSLLNKKKKEARRKRRERNFEKQKERKKKRQQARKTASVLSKDDVAPESGDTTVKKPESKKEQTPEHGKKKRGRGKAQVKATNESEDEIPQLVPIGKKTPANEKVEIQKHATGKKSPAKSPNPSTPRGKKRKALPASETPKAAESETPGKSPEKKPKIKEEAVKEKSPSLGKKDARQTPKKPEAKFFTTPSKSVRKASHTPKKWPKKPKVPQST
What is the function of this protein?
Regulates cellular senescence through inhibition of PTEN translation.  Acts as a pro-apoptotic regulator in response to DNA damage.
What are the official names of this protein?
Ribosomal L1 domain-containing protein 1, CATX-11, Cellular senescence-inhibited gene protein, Protein PBK1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family. Highly divergent.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Colocalizes with ING1 in the nucleolus after UV stress.
Protein: UC12_MAIZE
Sequence: IEEEVAAAAAVGSGGXHHHHLFHHKXPEHAHRHKIEEEVA
What are the official names of this protein?
Unknown protein from spot 237 of 2D-PAGE of etiolated coleoptile.
What is the protein family that this protein belongs to?
To tomato abscisic stress ripening proteins.
Protein: ASD_METBF
Sequence: MLAKGSEPWLFTATFITALFAVLSRAMNSSHLNHVAYIAMAMTFFMVLFFRDPERKVEVSDTYMISPADGTVIDIRGRKICIFMFLQNVHVNRAPISGKIREITYKKGGYLPAFCKDSERNERNEFIIHSKYGDVSVMQIAGTIARRIVSYSRVNDNIEQGQRIGMIRLGSRVDVTIPHDFEIIVRKGERVLAGKTIIATIKK
What is the function of this protein?
Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
What are the official names of this protein?
Putative archaetidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UVRC_KOCRD
Sequence: MADPASYKPARQDIPTNPGVYRFRDEHGRVIYVGKAKNLRNRVSSYFAPLHQLAPKTRAMVTTAAAVQWTVVGSEFESLQLEYTWIKEFAPRFNIAYRDDKSYPYLAVTMSEDVPRAMVTRGEKKPGNRYFGPYSQAWAIRDTLDALLRVFPVRTCTTGVYQRAERSGRPCLLGYIDKCSAPCVGNISQEEHRELADDLCRFMAGHAKPYIRELTRQMNEAAECMDFETAAARRDDVGALERVFERNTVVLTDSTDADFFAIAEDELEAAVQVFHVRGGRIRGQRGWITEKVEDVTTAQLMTNLLQQVYGEAQSGLAPAASGRRRTARHGSEDVVGQHRRTSELAYRQDTIPRAVHVSVLPDEADEIRAWLSELRGSQVTVQRPQRGDKAQLLETVAENARQALTLHKSRRAGDLTTRSASLQQLQEALGLPDALMRIECYDISHVQGTNVVASMVVFEDGLPRKSEYRKFSITGDAARDDTASMYDVIHRRFSRHVEQQRRAAEKGVSTGEVAADDDEGTTRAFAYPPNLVIVDGGPPQVAAAQRALDDLRVTDVHVVGLAKRLEEVWVPDDEFPVILPRASEGLFLMQRVRDEAHRFAITFHRQKRSKAMTVSALDEVPGLGPAKQKALLKHFGSVKKLRAATAEQILEVKGFGPALAVKVAQALGGEAAASSTAPAVDTGTGELLD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP4FN_HUMAN
Sequence: MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA
What is the function of this protein?
A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis.  Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis (PubMed:26056268).  Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum (PubMed:26056268).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:26056268).
What are the official names of this protein?
Ultra-long-chain fatty acid omega-hydroxylase, Cytochrome P450 4F22.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein.
Protein: FIME_ECOLI
Sequence: MSKRRYLTGKEVQAMMQAVCYGATGARDYCLILLAYRHGMRISELLDLHYQDLDLNEGRINIRRLKNGFSTVHPLRFDEREAVERWTQERANWKGADRTDAIFISRRGSRLSRQQAYRIIRDAGIEAGTVTQTHPHMLRHACGYELAERGADTRLIQDYLGHRNIRHTVRYTASNAARFAGLWERNNLINEKLKREEV
What is the function of this protein?
FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E. coli.  These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA.  FimE switches fimA off.
What are the official names of this protein?
Type 1 fimbriae regulatory protein FimE.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: GUAA_YERPS
Sequence: MTKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSPESTIENGSPRAPDYVFTAGVPVLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSALIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVASTDTCPFAIMANEEKRFYGVQFHPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDSSVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALAGVDEPEAKRKIIGRVFVELFDEEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PDXS_ROSCS
Sequence: MDKSTWTTKVGLAQMLKGGVIMDVVTPEQARIAEEAGAVAVMALERVPADIRAQGGVARMSDPELILAIKEAVTIPVMAKARIGHFVEAQVLEALGIDYIDESEVLTPADEEHHINKHKFRIPFVCGCRNLGEGLRRVAEGAAMLRTKGEAGTGNVVEAVRHARAVYSEIRRLQTMDEDELFTYAKNIQAPYELVRQVAESGRLPVVNFAAGGIATPADAALLMQLGVDGVFVGSGIFKSGDPARRARAIVAATTHYNEPEIIAEVSRGLGEAMVGIEIGKIPRDQLMAGRGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: URK_AERS4
Sequence: MSDTQHSCVIIGIAGASASGKSLIAQTIYEELVAELGAGQIGVITEDCYYRDQTHLTMEERVKTNYDHPNALDHDLLVQHLSQLVKGDAVNIPQYSYTEHTRMNDVTPFAPRRVIILEGILLLTDSRLRDLMDASIFMDTPLDICLLRRLVRDVQERGRTMDSVLKQYQKTVRPMFLQFIEPSKQYADVIVPRGGKNRIAIDMLKARILHMLIG
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_ALIF1
Sequence: MKPLTARQQEVFDLIKAKIDDTGMPPTRAEIARELGFRSANAAEEHLKALARKQVIEIIPGASRGIRILLQDADHHDEELGVPLIGQVAAGEPILAQEHVESHYKVDPGMFKPQADFLLRVNGESMKDIGIMDGDLLAVHKTQDVRDGQVVVARVDDDVTVKRLERKGSMVFLHAENEEFSPIEVDLTSQSLSIEGLAVGVIRSTTWM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: THYX_THEKO
Sequence: MDNGIRVKLVNYTKKPLETVTWAALISYWDEWETETFGRMSDKDVEMHLPRVLGYGHESILEHATLTFAIEGCSRVCSHQLVRHRLASYTQQSQRYIVLNPEDVEETFVIPSGIKEDPELLAEWKELMKKSIELYKKSVERGQHQEDARFILPQAVRTKIVVTMNLRELKHFLGLRACERAQWEIREVAWKMLEEIAKNDELRPIIKWAKLGPRCVQLGYCPEGELMPPGCWKRTGEKWKTLFEG
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: NPD_STAAR
Sequence: MKHDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVDTMPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDELHGTLNRFYCNACHKSYMKSDVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNKIEDADTLVVLGSSLVVQPAAGLISNFKGDNLIIINKDRTPYDNDATLVIHDDMVSVVKSLMTE
What is the function of this protein?
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
What are the official names of this protein?
NAD-dependent protein deacetylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class U subfamily.
What are the subcellular locations of this protein?
Cytoplasm.