PharMolix/UniProtQA huggingface dataset:
Protein: TEFF1_HUMAN
Sequence: MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV
What is the function of this protein?
May inhibit NODAL and BMP signaling during neural patterning (By similarity).  May be a tumor suppressor in brain cancers.
What are the official names of this protein?
Tomoregulin-1, TR-1, H7365, Transmembrane protein with EGF-like and one follistatin-like domain.
What is the protein family that this protein belongs to?
Belongs to the tomoregulin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: COX3_DEBHA
Sequence: MTNNTRGYIQLHPFHLVGPSPWPMFTSFSLMNLALSLGLTAHGYMNNNMFMLLSTMTVLYSMTLWFKDIMAESTYLGDHTVAVKRGLMQGFLMFVVSEMLMFSSLFWAFLHSALNPTVEMGMSWPPAGMEAISAAELPLLNTMILLASGVTMTYAHHALMNGNRQNTLYGFAYSTLLMVLFVMFQGLEYTYAGFTITDGVYGSTFFALTGLHGLHMMMLIMMLAMCTMRVYNYDFTNTSHVGAETTILYLHVLDVMWLFMYMIVYWWGA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III, Cytochrome oxidase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SDHD_ALKCK
Sequence: MDIAGKNREQWLAAYPLLQQIVLTKEVWWANPNRQPASEGLARLSLKEEDVKEAEQRLRRFAPYIASVFPETKGAGGLIESPLIDIPTMKHKLDQRFGQNVPGRLLLKGDHALPISGSIKARGGIYEVLKHAESLLVDQQILTKQDDYSLIATDAVQSFFSSYAIVVGSTGNLGLSIGIISAKLGFRVTVHMSDDAKQWKKDMLREKGVRVVEHSADYSKAVEEGRKESDADPNSYFIDDEHSIDLFVGYAVAAFRLKEQLQEKGIAVTKDQPLHVYLPCGVGGGPGGVAFGLKLVFGDAVRCFFAEPTHSPCMLIGMLTGKHQHISVQDFGIDNQTAADGLAVGRPSGFVGRMMAPLLEGIYTIADPMLYTLLADLADAEGLYLEPSAVAGLYGPVQLEKRGLYTDAATHLVWATGGSMVPKEIMETDYQLGVNLRTEQ
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: RB40C_MOUSE
Sequence: MGTQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYAYSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASGAGGSGSKGNSLKRSKSIRPPQSPPQNCSRSNCKIS
What is the function of this protein?
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
Ras-related protein Rab-40C, SOCS box-containing protein RAR3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: UREF_HAEIE
Sequence: MAQTLNRSLTDLGALLHLVDPTLPIGGFNHSNGLETFVQQRVVESKATLEEYVQTQLLQNWIYNDGAYLSLAFDAMNEGNFDRLCELDWQLSATKVARESREGSFKLGVRLLKIFIRYETHTLLTAYQQAIAEKRVQGYFPIVFAMVAQAMGLTKADTLYAFYYNAAVGAITNGVKLIPLSQMDGQDILFDLRGSLVQAVELSLDPDEEWLGAATLANDIRAMQHEVLYTRLYMS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHE10_LACTC
Sequence: MRRVRGVGNLLVTILVVLIGFKQARKYCESNEAEFCRLTSLSRASPWWNEHIDPYWDSYVSPCVTKIHDYEHKLDEWAAPRIDRAYYQVQDIVETKVVPVTYKWYKTVQFKTQVYYNGHFVPFLGHARILAKQWLASEGFFQRLYLHVQQGLFCLRNWSLWVWNGSLEAFNEIHSWSGHALQEISNKFSVTENQSGEPVTDEDPSDTDESKYYDAEYFEGEQGDYNEDDETVYLTSTIIETVTLSDEKQLDKSTSAANGDDGSSLDVPLRDLVQDEFQAWSNTVEQKASNTLTQFDSEVEELVEAKLSKAQPNITGLLQGISESFQSHYRIINRAILDVDCTMELDPETGEQLYFNKDGTQLRKYVTRPLMREFFSSAHAHVDERLEMVRARLEKFVAAVNKEVEQVRQEHLEVYEEWGDVMVSEWSKRMAYVDVVAAMGAEDMNQQQHDNWKRFLKLKKQVVNTRDLLMQHPAKLERLQKFLNDIQFTLMALQRDAGEYLFILRSQANIAFQTREKLEREREEEERRKLEQERQIQEQKEREQQELAENEARAARERLALEQGQGQEQLEQNSDEAFFSMEDITATPLGADDNTDYENALDDADSQLSESGDSEDNFYDSYEGDEEDASRELERLERESAERETLDRLELGQRQKLQEEQHRDELHHSSQAN
What is the function of this protein?
Involved in spore wall assembly.  May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria.
What are the official names of this protein?
Outer spore wall assembly protein SHE10, Sensitivity to high expression protein 10.
What is the protein family that this protein belongs to?
Belongs to the SHE10 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EFTU_STRT2
Sequence: MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSAVNTPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDLLSEYDFPGDDIPVIQGSALKALEGDSKYEDIIMDLMNTVDEYIPEPERDTDKPLLLPVEDVFSITGRGTVASGRIDRGVVRVNDEVEIVGLKEESQKAVVTGVEMFRKQLDEGIAGDNVGVLLRGIQRDEIERGQVLAAPGSIKPHTKFKGEVYILTKEEGGRHTPFFNNYRPQFYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEKGTTFSIREGGRTVGSGIVTEIEA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUB7_ARTGP
Sequence: MGFITKAIPLALAAASVINGAEILETRAGVQTLADKYIVVMNDGMTDKDFDSHRSWVNRTHRRRLVRRGAKAMTGMKHTYRFPTGMKGYSGHFDEQMINEIAKRADVKYIERDARVQINAIEMQDNVPSWGLARVGSKEPGGTTYYYDSSAGQGVTAYVIDTGTDIKHEEFSGRATWGGNFVDDIDMDCNGHGTHVSGTVAGTKFGVAKKANVVGVKVLDCDGSGSNSGVIMGMEFATNDAKKKGAGKAVANMSLGGAFSQASNDAAAAIAQGGVFLAVAAGNDNVDAAMASPASEPSICTVAASTEQDGKASFSNYGQVVDVYAPGDGITSAKPGGGSQVLSGTSMASPHVAGLAAYLIGTGKSGGPQLCDTIKNMAIDVITNPGAGTTGKLINNGSGK
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 7.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRAM2_HUMAN
Sequence: MSIQAPPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFREAFSRRHFQTLTVMVQAWPFTCLPLVSLMKTLHLEPLKALLEGLHMLLTQKDRPRRWKLQVLDLRDVDENFWARWPGAWALSCFPEAMSKRQTAEDCPRTGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHLCCSKLVNYLTPIKYLRKSLKIIYINSIGELEIHNTCWPHLIRKLYCYLKEMKTLCKLVFSRCHHYTSDNELEGWLVTRFTSVFLRLEHLQLLKIKLITFFSGHLEQLIRCLQNPLENLELTCGNLLEEDLKCLSQFPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLETLVLEGCQIHYSQLSAILPGLSCCSQLTTFYFGSNCMSIDALKDLLRHTSGLSKLSLETYPAPEESLNSLVRVNWEIFTPLRAELMCTLREFRQPKRIFIGPTPCPSCGSSPSEELELHLCC
What are the official names of this protein?
PRAME family member 2.
What is the protein family that this protein belongs to?
Belongs to the PRAME family.
Protein: RS9_PHOV8
Sequence: MEVVNALGRRKRAVARVFVSEGTGKITINKRDLAQYFPSTILQYVVKQPLNKLEAAEKYDIKVNLYGGGFTGQSQALRLAIARALVKINPEDKTALRSEGFMTRDSRSVERKKPGQPKARRRFQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: HEM3_ACTSZ
Sequence: MQQEILKIATRQSPLALWQANFVKDRLTEIYPDLTVELVPMVTKGDVILDTPLAKIGGKGLFVKELENALLNGDADIAVHSMKDVPMEFPAGLGLSVICKREDPRDAFVSNRYRTLDDLPPGAIVGTSSLRRQCQLKKRRPDLNIRSLRGNVGTRLSKLDQGDYDAIILASAGLIRLALPERIASFIETEISLPAAGQGAVGIECRINDQRVQKLLAPLADTETTACVLAERAMNNRLQGGCQVPIGGYAVLNGNELHLRALVGALDGSKIIRAEGKSAVENAEVLGIQIAESLLAQGADKILAEVYNG
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: EX53_BUCAP
Sequence: MPYTKKKPIIIVDGSLYLYRSYFTFQNFNSNEENPSGAIYGMLKTIQNILNKNYNSKKIIIIFDSSKKNFRNTIFKEYKSNRSAMPNKLYVQIQPLFKILEEIGIKTLSILGIEADDIIGSLAYKLEQKGEQVLIVSHDKDMIQLITDNINVLNISKNSILTPEKIQEKYGIYPKEFIDLLALMGDSSDNIPGVPKIGIKTALFLLKKFSNIKNIYNNIEKIQSLPFRNAKNAAIQLKNYKKTAFLSYQLAKIKLDVPINITSEEITLKKTCFKKLSNLIRWYSFNE
What is the function of this protein?
5'-3' exonuclease acting preferentially on double-stranded DNA.
What are the official names of this protein?
5'-3' exonuclease.
Protein: GCSH_TROW8
Sequence: MFDESDLVYSKEHEWVFIDDDIAWVGITKYAVKKLGDIVYIDLPSQDALIVQGECVGEIESTKSVSEIYSPVSGRVIAVNEDVISSPGLLNSDSSVWLFKAECENIPELMDWGQYSEYTKE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: CAD18_HUMAN
Sequence: MKITSTSCICPVLVCLCFVQRCYGTAHHSSIKVMRNQTKHIEGETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYGEIESERTT
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
What are the official names of this protein?
Cadherin-18, Cadherin-14.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: SPEE_MOUSE
Sequence: MEPGPDGPAAPGPAAIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIEVSKKFLPGMAVGFSSSKLTLHVGDGFEFMKQNQDAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGILCCQGECQWLHLDLIKEMRHFCKSLFPVVDYAYCSIPTYPSGQIGFMLCSKNPSTNFREPVQQLTQAQVEQMQLKYYNSDMHRAAFVLPEFTRKALNDIS
What is the function of this protein?
Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM).  Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane.  Has extremely low activity towards spermidine (By similarity).
What are the official names of this protein?
Spermidine synthase, SPDSY, Putrescine aminopropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
Protein: LECA_CANBN
Sequence: MAISKKSSLYLPIFTFITMLLMVVNKVSSSTADANALHFTFNQFSKDQKDLILQGDATTGTDGNLELTRVSSNGSPQGNSVGRALFYAPVHIWESSAVVASFDATFKFLIKSPDSEPADGITFFIANIDSSIPSGSGGRLLGLFPDANIIKNSTTIDFNAAYNADTIVAVELDTYPNTDIGDPNYPHIGIDIKSIRSKKTTRWNIQNGKVGTAHINYNSVGKRLSAIVSYPNSDSATVSYDVDLDNVLPEWVRVGLSATTGLYKETNTILSWSFTSKLKSN
What is the function of this protein?
D-mannose-specific lectin.
What are the official names of this protein?
Lectin CaBo, Lectin Cbo.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: DNAJ_PSEAB
Sequence: MAKRDFYEVLGVERGASEADLKKAYRRLAMKYHPDRNPGDKEAEDKFKEANEAYEVLSDASKRAAYDQYGHAGVDPNMGGGAGAGFGGASFSDIFGDVFSDFFGGGGARGGSRGGAQRGADLRYTLDLDLEEAVRGTTVTIRVPTLVGCKTCNGSGAKPGTTPVTCTTCGGIGQVRMQQGFFSVQQTCPRCHGTGKMISDPCGSCHGQGRVEEQKTLSVKVPAGVDTGDRIRLTGEGEAGSMGGPAGDLYVVVNVREHPIFQRDGKHLYCEVPISFADAALGGELEVPTLDGRVKLKIPESTQTGKLFRLRGKGVAPVRGGGAGDLMCKVVVETPVNLDKRQRELLEEFRKSLQSDTSHSPKASGWFEGMKRFFDDL
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBT_CERS4
Sequence: MKAPFTSLAGFRAVFETLPQVDAEAVEAATARNETLTKPKGALGRLEELAIWYAGWIGDGRPALERPQVAIFAGNHGIAARGVSAFPPEVTVQMVANYRAGGAAVNQLCHVAGASMTVTELELDRPTLDFTVSPAMTEDELVAALAAGWEAVDDESDLLVVGEMGIGNTTAAAAIAAALFGGTAAEWTGRGSGVAGSALEAKTRVVAEGLERHADALSDPLEVLRCLGGREIAAMAGAIARARVGRTPVILDGFICTSAAAVLHALTPSALDHAIAGHVSAEGAHPAALARIGKEPLLDLGMRLGEGTGAIVAINILRSAVACLSGMATFAEAGVSGG
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: BST12_CAEEL
Sequence: MTIPYLADLKDQTECKTCPKILTRCKGSLYKVILHEFLMTAGAYFGVFLVFRFAINETQREYAAEVFKKLKEQQNVCIPMQMMLAFFIATVADQWEKIFENVGYIENAALAVATFLPDGKEKRDNNGNVILAKVDNSNVRRNIIRYLVLSQILGIRDVSELVKKRFANYDMIKATGVLQDHEEPLLKKVPCKTYAESFVPITWIMSILQKFASKNEENLYYDTVYLEITDFYKKIIKLTRYDLIPIPLAYPQAVFLAVRIYFFFCLFTRQHLDLEENWALSHWGFPLLTTLQFIFLVGCMKVAEILLNPMGQDDENFECNYVMDKNLFVGLTIVSSEHTECPELEEVIGDDYVPWYPDDCKSKEEKNQEELKKYLESVDFQAVTSSDQGENDEVSTMMKVEQNSLLVCGREKFYEGGGFRNSDVYPKQRANYPH
What is the function of this protein?
Forms chloride channels.
What are the official names of this protein?
Bestrophin homolog 12.
What is the protein family that this protein belongs to?
Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VL2_HPV16
Sequence: MRHKRSAKRTKRASATQLYKTCKQAGTCPPDIIPKVEGKTIAEQILQYGSMGVFFGGLGIGTGSGTGGRTGYIPLGTRPPTATDTLAPVRPPLTVDPVGPSDPSIVSLVEETSFIDAGAPTSVPSIPPDVSGFSITTSTDTTPAILDINNTVTTVTTHNNPTFTDPSVLQPPTPAETGGHFTLSSSTISTHNYEEIPMDTFIVSTNPNTVTSSTPIPGSRPVARLGLYSRTTQQVKVVDPAFVTTPTKLITYDNPAYEGIDVDNTLYFSSNDNSINIAPDPDFLDIVALHRPALTSRRTGIRYSRIGNKQTLRTRSGKSIGAKVHYYYDLSTIDPAEEIELQTITPSTYTTTSHAASPTSINNGLYDIYADDFITDTSTTPVPSVPSTSLSGYIPANTTIPFGGAYNIPLVSGPDIPINITDQAPSLIPIVPGSPQYTIIADAGDFYLHPSYYMLRKRRKRLPYFFSDVSLAA
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: ETR1_ASHGO
Sequence: MQALNTTKRLMSTKQFPLFKSLLYSSHDPADCTQVLKVHSYTPKVGADESILLRTLAFPINPSDINQLQGVYPSVPEKTLDYSTEKPAAIAGNEGVFEVMSVPQGERRLAVGDWVIPLYSNTGTWTNYQTCRDAGTLVKVNGLDLYTAATIAVNGCTAYQLVNDYVQWDPSGNEWIVQNAGTSAVSKIVTQVAQARGVKTLSVIRDRENFAEVAKELEERYGATKVISETQNNDKDFSKDELPVILGPNARVRLALNSVGGKSSGAIARKLERDGTMLTYGGMSRQPVTVPTTLLIFNGLKSLGYWITENTKRNPQSKIDTISALMRMYGDGQLQPPEADIKKIEWDVQKMNDEQLLEAVKNGIQSNGKSVVVLKW
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II).  Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.  Required for respiration and the maintenance of the mitochondrial compartment.
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase, mitochondrial, 2-enoyl thioester reductase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RUVB_HELPY
Sequence: MKERIVNLETLDFEISQEVSLRPSLWEDFIGQEKIKSNLQISICAAKKRQESLDHMLFFGPPGLGKTSISHIIAKEMETNIKITAAPMIEKSGDLAAILTNLQAKDILFIDEIHRLSPAIEEVLYPAMEDFRLDIIIGSGPAAQTIKIDLPPFTLIGATTRAGMLSNPLRDRFGMSFRMQFYNPSELALIIKKAAVKLNQDIKQESADEIAKRSRGTPRIALRLLKRVRDFALVKNSSLMDLNITLHALNELGVNELGFDEADLAYLSLLANAQGKPVGLNTIAASMREDEGTIEDVIEPFLLANGYLERTAKGRIATPKTHELLKIPTLNPQTLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RM44_SCHPO
Sequence: MIFGYINKLSILNVNPFSKASQSAKLLLAVASKETSNSLYGLNLITSLASKDTNSKPSVEVVYKDGKKLTVDPTKMNIGRLTELIDDYSKTLKFKEMMQK
What is the function of this protein?
Involved in mitochondrial genome encoded proteins translation.
What are the official names of this protein?
54S ribosomal protein L44, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL53 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LEXA1_PSESM
Sequence: MIKLTPRQAEILGFIKRCLEDNGFPPTRAEIAQELGFKSPNAAEEHLKALARKGAIEMTPGASRGIRIPGFEARPDESSLPVIGRVAAGAPILAQQHIEESCNINPSFFHPSANYLLRVHGMSMKDVGILDGDLLAVHTTREARNGQIVVARIGDEVTVKRFKREGSKVWLLAENPDFAPIEVDLKDQELVIEGLSVGVIRR
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: MAZE3_MYCTU
Sequence: MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEILATNTSATGDLDTLAGHCARTALDID
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Upon expression in E. coli and M. smegmatis neutralizes the effect of cognate toxin MazF3.  Overexpression of MazE3 alone decreased persister cells formation in M. smegmatis upon challenge with gentamicin or kanamycin.
What are the official names of this protein?
Antitoxin MazE3.