PharMolix/UniProtQA huggingface dataset:
Protein: RS7_SACS2
Sequence: MSLENLQLDIKVFGKWDTKVEIRDPSLKKYISLMPVYLPHTGGRHEHRRFGKAKVPIVERLINQIMRPGRNKGKKHLAYNIVKLAFDIIYLKTGQNPIQVLVRAIENSAPREEVTRIMYGGIVYYVAVDVSPQRRIDLALRHIATGAKDASFNNPKPIEEVLAEEIIAAANNDSKSFAIKRKEEIERIALSSR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: MURB_LISMC
Sequence: MNNLQTQFPHIAIKLNEPLSKYTYTKTGGAADVFVMPKTIEETQEVVAYCHQNKIPLTILGNGSNLIIKDGGIRGVILHLDLLQTIERNNTQIIAMSGAKLIDTAKFALDESLSGLEFACGIPGSIGGALHMNAGAYGGEISDVLEAATVLTQTGELKKLKRSELKAAYRFSTIAEKNYIVLDATFSLALEEKNLIQAKMDELTAAREAKQPLEYPSCGSVFKRPPGHFAGKLIQDSGLQGHIIGGAQVSLKHAGFIVNIGGATATDYMNLIAYVQQTVREKFDVELETEVKIIGEDK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLF_ASPFN
Sequence: MAAFPAYLALLSYLVPGALSHPEAKTLTSRASTEAYSPPYYPAPNGGWISEWASAYEKAHRVVSNMTLAEKVNLTSGTGIYMGPCAGQTGSVPRFGIPNLCLHDSPLGVRNSDHNTAFPAGITVGATFDKDLMYERGVGLGEEARGKGINVLLGPSVGPIGRKPRGGRNWEGFGADPSLQAFGGSLTIKGMQSTGAIASLKHLIGNEQEQHRMSSVITQGYSSNIDDRTLHELYLWPFAESVRAGAGSVMIAYNDVNRSACSQNSKLINGILKDELGFQGFVVTDWLAHIGGVSSALAGLDMSMPGDGAIPLLGTSYWSWELSRSVLNGSVPVERLNDMVTRIVATWYKMGQDKDYPLPNFSSNTEDETGPLYPGALFSPSGIVNQYVNVQGNHNVTARAIARDAITLLKNNDNVLPLKRNNTLKIFGTDAGTNSDGINSCTDKGCNKGVLTMGWGSGTSRLPYLITPQEAIANISSNAGFHITDTFPSGVTAGPDDIAIVFINSDSGENYITVDGNPGDRTLAGLHAWHNGDNLVKAAAEKFSNVVVVVHTVGPILMEEWIDLDSVKAVLVAHLPGQEAGWSLTDILFGDYSPSGHLPYTIPHSESDYPESVGLIAQPFGQIQDDYTEGLYIDYRHFLKANITPRYPFGHGLSYTTFNFTEPNLSIIKALDTAYPAARPPKGSTPTYPTAKPDASEVAWPKNFNRIWRYLYPYLDNPEGAAANSSKTYPYPDGYTTEPKPAPRAGGAEGGNPALWDVTFSVQVKVTNTGSRDGRAVAQLYVELPSSLGLDTPSRQLRQFEKTKILAAGESEVLTLDVTRKDLSVWDVVVQDWKAPVNGEGVKIWVGESVADLRVGCVVGEGCSTL
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase F, Beta-D-glucoside glucohydrolase F, Cellobiase F, Gentiobiase F.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PCP14_ARATH
Sequence: MAVRLIPTIWLFIVFAVIVSALPSLVSSRKLLEVKKQENLTVREEEKSHMPHVTKTSTLSALPKGKIPNSTPSKKGHAAVFAGKLRSRHLSTVDRYLRSVPSPGVGH
What is the function of this protein?
Extracellular signaling peptide that may regulate primary root growth rate and systemic nitrogen (N)-demand signaling.
What are the official names of this protein?
Precursor of CEP14, PCEP14.
What is the protein family that this protein belongs to?
Belongs to the C-terminally encoded plant signaling peptide (CEP) family.
What are the subcellular locations of this protein?
[C-terminally encoded peptide 14]: Secreted, extracellular space, apoplast. Note=Accumulates in xylem sap.
Protein: COAX_ALKCK
Sequence: MMLAIDIGNSSIVTGVYDENDQLAFIFRIATTHDKTSDEYAMLLHSFFEQKGCRFNDVTGVIIASVVPTIMHRFRRMCQDYLHVTPLIVGPGIRTGLSIHYQDPKEVGADRIANAVAAIARYGAPCIVVDIGTATTFCCIDAKHRYRGGVIAPGAAISTAALSNKASKLPKIELTKPASVVGKTTVASMESGTFYGHIAMIDGVVERIKEEQRLDDAKVIATGGLAYLYAEESKQIQHLEQELTLSGLKYIYDKNQ
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_CUPTR
Sequence: MTQTETMAAAGAAKTEPKVRPAKALQGVKGMNDMLPADAPLWEHFENAARAMLRAYGYQQIRTPIVEHTQLFVRGIGEVTDIVEKEMYSFTDSLNGEQLTLRPEGTAAAVRATIEHNLLYDGPKRLWYTGPMFRHERPQRGRYRQFHQLGAEALGFAGPDVDAEIILMCQRLWDDLGLTGVRLEINSLGQADERAAHREQLIKYLEGFQDILDDDSKRRLYTNPLRVLDTKNPALQDMAANAPKLIDFLGEESLAHFEGVQRLLKANNIPFKINPRLVRGLDYYNLTVFEWITDKLGAQGTIAGGGRYDPLIAQMGGKPAPACGWAMGIERIIELIREEGVVPDAVGCDVYLVHQGEAAAQQAMVAAERLRDAGLDVVLHASPDGKGGSFKSQMKRADASGAAYAVIIGDDEVAAGVVQVKELRQREQAEGGGQQATVPADGLVDYLIDAMVGASE
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_ALKMQ
Sequence: MQDQEEERMITNQPKEEDLILENGLRPKFLVDYIGQNSVKERLKIFIEAAKQRQEPLDHVLLYGPPGLGKTTLANIIANEMNVNIKITSGPAIERPGDLAAILTNLAANDVLFIDEIHRLNRTVEEVLYPAMEDFALDIIIGKGPSARSIRLDLSQFTLIGATTRAGQLSSPLRDRFGVICKLELYNNKQLTAIVKRSARILDAYIDDEGATEIASRSRGTPRIANRLLRRVRDYAQVKSDGRITKRVAEEALILLEVDSLGLDNTDKKMIETMIYNFNGGPVGLDTLAATTGEERNTIEDVYEPYLLQMGFINRTPRGRIVMQKAYEHFNIPSAE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: BIOD_MYCTO
Sequence: MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_DEHMC
Sequence: MISPENVVPMVIESSARGERAFDIYSLLLKERIIFLGSQINDQVANLVIAQLLFLDREDPDKDISLYIHSPGGVISAGLAMYDTMQLIRPKVSTICVGVAASMATVLLCAGAKGKRYALPNATIHMHQAMGGAQGQASDIEIAAREIMRQQDILRNILVKHTGQTMEKIVHDSDRDYYLSAQQAVEYGLIDEILQKPENK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_BURL3
Sequence: MTAPLTLALSKGRIFEETLPLLAAAGVQVTEDPETSRKLILPTTNPDLRVIIVRASDVPTYVEYGAADFGVAGKDVLVEHGGSGLYQPIDLNIARCRMSVAVSAGFDYASAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEEIMAISSRLVVNQAALKLKRTALKPILDAFERASQNGG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPR90_ARATH
Sequence: MRISISSVVSSTTSRIVHRNLQGKGNPRIAPSSIDLCGMCYWGRAFSSGSGDYREILRNGLHDMKLDDAIGLFGGMVKSRPLPSIVEFNKLLSAIAKMKKFDVVISLGEKMQRLEIVHGLYTYNILINCFCRRSQISLALALLGKMMKLGYEPSIVTLSSLLNGYCHGKRISDAVALVDQMVEMGYRPDTITFTTLIHGLFLHNKASEAVALVDRMVQRGCQPNLVTYGVVVNGLCKRGDTDLALNLLNKMEAAKIEADVVIFNTIIDSLCKYRHVDDALNLFKEMETKGIRPNVVTYSSLISCLCSYGRWSDASQLLSDMIEKKINPNLVTFNALIDAFVKEGKFVEAEKLYDDMIKRSIDPDIFTYNSLVNGFCMHDRLDKAKQMFEFMVSKDCFPDVVTYNTLIKGFCKSKRVEDGTELFREMSHRGLVGDTVTYTTLIQGLFHDGDCDNAQKVFKQMVSDGVPPDIMTYSILLDGLCNNGKLEKALEVFDYMQKSEIKLDIYIYTTMIEGMCKAGKVDDGWDLFCSLSLKGVKPNVVTYNTMISGLCSKRLLQEAYALLKKMKEDGPLPNSGTYNTLIRAHLRDGDKAASAELIREMRSCRFVGDASTIGLVANMLHDGRLDKSFLDMLS
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g62590.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: THIG_BACP2
Sequence: MLHIGGKTFTSRLLLGTGKYPSFEVQKEAVNVSEAEILTFAVRRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTADEAVRIARLAKASGLCDMIKVEVIGCSRSLLPDPVETLKASEMLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGSGQGLLNPLNLSFIIEQAKVPVIIDAGVGSPKDAAYAMELGADAVLLNTAVSGAKDPVKMAKAMKLAIESGRLGFEAGRIPLKNYGTASSPQEGMPAF
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJDP_ECOLI
Sequence: MKRFPLFLLFTLLTLSTVPAQADIIDDTIGNIQQAINDAYNPDRGRDYEDSRDDGWQREVSDDRRRQYDDRRRQFEDRRRQLDDRQRQLDQERRQLEDEERRMEDEYGR
What are the official names of this protein?
Uncharacterized protein YjdP.
Protein: G6PI2_NEIG1
Sequence: MDAFTRAWYALERHYQDTCHILLRDRFAAEPDRFERMHERLDGMLFDYSKNRFGEDTLQLLCRLAETADLEGKMRALRTGAKVNGSEGRAALHTALRLPDGADAVYADGRDVLPEIRRELNRALKFAHSLDDGLYQGITGKRIADFVHIGIGGSDLGPAMCVQALEPFRRQISVHFVSNADPACLDEVLCRLNPETTMFCVASKSFKTPETLLNAEAVKAWYRGAGFSESETAHHFCAVSADTEAAQSFGIAAERVFAMYDWVGGRYSVWSPVGLPVMVAVGGARFRELLAGAHAMDSHFFHTPPRRNIPVLMALIAVWYNNFQHADGQTAVPYSHNLRLLPAWLNQLDMESLGKSRASDGSPAACKTGGIVFGGEGVNCQHAYFQLLHQGTRLIPCDFIVPMTAQGAEDGRSRFTVANAFAQAEALMKGKTLDEARAELADLPEAERERLAPHKEFPGNRPSNSILLDRLTPCNLGMLMAAYEHKTFVQGAIWNVNPFDQWGVEYGKQLAKTIIGELEGGTSVHDASTEGLMAFYRECRLKGGGAA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase 2, GPI 2, Phosphoglucose isomerase 2, PGI 2, Phosphohexose isomerase 2, PHI 2.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_ACIET
Sequence: MTHNTDLNLPLFERAKALIPGGVNSPVRAFRAVGGTPRFITRAQGAYMWDANGQRFIDYIGSWGPMILGHGHPAVLEAVQKAALEGFSFGAPTEREVELAEEIIRHVPSMEMIRLVSSGTEAGMSAIRLARGATRRNKIIKFNGCYHGHADSLLVKAGSGLATFGHATSAGVPQEVVQHTLVLEYNDVAQLEEAFTLHGPDVACVIMEPIAGNMNFVRASVPFMRRARELCTQHGALLVIDEVMTGFRVALGGAQSLYAQAIPGFKPDITVLGKVIGGGMPLAAFGGSRAVMEQLAPLGPVYQAGTLSGNPVATACGLATLREIAKPGFYDALGARTRALIDGLAGAASAAGVPFCGDTQGGMFGFFLLPQLPQNYPEVLNTDGMRFNTLFHGLLDGGVYIAPALYEAGFVSAAHTEQDIADTVAVARDVFQKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_ECOL5
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SCPA_ENTFA
Sequence: MSFLQEINLKLDVFEGPLDLLLHLIQKLEIDIYDIPITAVTEQYMSYIHAMQTLELEVAGEYLVMAATLMAIKSQMLLPKQELEIIDDEDFFEEEDPREALVAQLLEYRKFKYAATVLHEKEEERKLYYTKEPMDMDDYKEEDTTLPPNQINTIDLFLAFHAMLEKKKNRQPVETTVASDDVSIEEKISAISERMRQVQKGKAVSFDSFFDSYSKQEIVTTFMALLELMKTGAIYAEQENNYSEILLFNTETQQEDTTEVEETQ
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: SLYX_ALIF1
Sequence: MTTTIEQLEQKISDLECQMAFQEQTIDELNDALSQQQLLITNMQVQMKFMVGKMKTMDSSNMADASEETPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: RL14_STRPJ
Sequence: MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVKQATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIREDKTPRGTRIFGPVARELREGGFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: LSPA_VIBPA
Sequence: MSEKALTLKQSGVRWLWLAIVIFLADIGIKYVVMNNMGYGWANRIEILPFFNLLYVHNYGAAFSFLSDQAGWQRWLFTGIAFVVTGLLTYWMSKLPAKEKWNNIAYAMIIGGAVGNVFDRVIHGFVVDYLDFYWGNYHWPAFNLADMAICLGAAMIILDGFRKKDTAKA
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRPE_MYCGE
Sequence: MCEKSQTIKELLNAIRTLVVKNNKAKVSMIEKELLAFVSELDKKFKQQLNNFNELQQKIPLLQKANEEFALKFERMQREAQNQIQAKLDELNLKNKKELEQAKKYAIAKTLDQPLNIIDQFEIALSYAQKDPQVKNYTTGFTMVLDAFSRWLEANGVTKIKIEPGMEFDEKIMSALELVDSNLAKNKVVRVSKSGYKLYDKVIRFASVFVSKGNKKS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFT1_XENTR
Sequence: MKHRPVHERQCSTETKNWKENTQLIMQSSSGHTHHQPGSNDSPSVCMSLPVPQLSAEGSCTAGDVTIDLSSPESHHGARSSSRRVRPGNGRSLSRHGHTHSHDANGPEDANDADSREQSNSISEVFHFYKWLEKSFPYILIFSAKLVVQHITGISVGIGLLTTFLYANKCIVNQVFLRDKCSKLQCLWILVFLLFSSLLLYYTFSSQALYYSLVFMNPSLGPLHFFDALWVVGITDFIGKFFFMGLKCIILLVPSFVMSHKSKGYWYMALEEVAQCYCMLVSTPVWFRYLIDYGNQNSGAEWHFGILLALLYLILKLLIIFGQRKTSSNSLRLFLTQPNYGAAATKSQCSEVDGMCAICQAEFIKPIVLVCQHVFCEECISLWFNKEKTCPLCRTVISNQSHKWKDGATSLQLRIF
What is the function of this protein?
E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation.  Protects cells from ER stress-induced apoptosis.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNFT1, RING finger and transmembrane domain-containing protein 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RPOZ_JANSC
Sequence: MARVTVEDCVDKVPNRFELVMLASHRAREIAAGDPLTIDRDNDKNPVVSLREIADETQSADDLRERLIESHQTQIEVDEPEEDAMALLQGVEQDRPAQDDMSEEQMLRALMEAQGQK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: MNME_LACAC
Sequence: MAQVLTEFDTIAAISTPIGEGGISIVRMSGEDAIKIANEVFKGADLAQVPTHTIHYGHIIDPDTGKTIDESMVTVLRAPKTFTCEDIVEINCHGGIVVTNHILQLLLKHGARMADPGEFTKRAFVNGRIDLTQAESVMDIVRAKTDKARQVAVSQLEGGLLHKIRTMRQEILDTLANVEVNIDYPEYDADTVTANQMADTAKSVIEKIDRLLKTAQEGKILRNGLATAIVGQPNVGKSSLLNYLTQSDKAIVTDVAGTTRDTLEEYVSVKGVPLELIDTAGIHHTDDKVEKIGVERSKKALERADLVLLLIDASKELTAEDKSLINETDSKKRIIILNKSDLGQKITVEQMKKLTGSEVISTSILKEDNMDELEELINKLFFAGIENSNDQVMVTNQRQTSLLHKAKSELEDVIQAVDDGIPVDIAQIDFTGAWDTLGEITGESAPDELITQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED29_CAEEL
Sequence: MSGQGPPPSMTPQQQHMLMQQQQQQQMMRQQQMQQQQMQQQRQQQIQQQAQQPYQRARTPQMVPQGGSPGGAHLQMHPHLQPQGQMQPRSPLVGAQLQAPSSVPTAANPTTPQMMQQQMGMNQPMSLPPTHVSRPGSVAPPSSVPVNLQHTSGAPGLPGSQMEHQYPMHLQPQQQTLSRPGSQQSQHIQQPGSIQRPGSVLAPGSIPPGGPASQTGPQSIQVFGPGSVQPPGSTQAPSSVQPASTFNPGSIQAPASQQPPASVQPPPSAASGSTVAGAQSSKEPLKPNEEQIRMVQDPVDLVRNLVQKDLRNSLVEMNKRGAELVRQKQEGEVNEDGKAQYSRATNDFHAVCDEIDRTLTTVLETAKQLSKLDKVFFDRSSRDLDGEVMVNSVQNFVDNTEIVQRMFDDTIGSVTSSMESMRRRQKKWEDQHKNDDVEMME
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes (By similarity).  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery (By similarity).  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity).  Involved in development of gonad and seam cells (PubMed:19500563, PubMed:15020414).  Plays a role in temporal regulation of seam cell division, probably acting as a part of the Mediator complex (PubMed:19500563).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 29, Mediator complex subunit 29.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 29 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVC_CLAMS
Sequence: MRILGIDPGLTRCGVGVVDVYADRSARLVDVQVVRTSPTAELHHRLLAVGDGIEELVDRHRPSVVAVERVFAQDNLSTVMGVAQITGVALVGAARRGLDVALHTPSEVKAAVTGYGQADKRQVATMVARILGLDELPTPADASDALALAICAGWRAGMSRAGIAGTQAPTRTGVASAADAAAGAGPTAAQAAWLAAERAQRGRR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: YQGF_NITMU
Sequence: MEEAEKASQPHAGTALAFDFGEKRIGVAIGNLELGLAHPLVTLSNKNKEECLKSIARLMDEWKPVLLVVGLPVHADGTEHELTRRSRRFAHRLQARFGIRTVLEDERYTSISASSALDEASVRGRRQKQVLDQIAAQLILQSYFDQRNATT
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMTF1_RAT
Sequence: MSTVEEDSDTVTVETVNSVTFTQDTDGNLILHCPQNDPDEIDSEDSTEPPHKRLCLSSEDDQSIDDSTPCISVVALPLSENDQSFEVTMTATTEVADDELSEGTVTQIQILQNDQLDEMSPLGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPVLLENKSGSGVPNSNCNSSVQHVQIRVARLEDNTAISPSPMAALQIPVQITHVSSTDSPAASVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTTSPTVTLAAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSISQAELTADSDLHSSDFPEPPDALEADTFPDEIPRPKMTIQPSFNNAHVSKYSDQNSTELMNSVMVRTEEEIADTDLKQEPPSDLASAYVTEDLESPTIVHQVHQTIDDETILIVPSPHGFIQASDGIDAESVLPLTTLTDPIFQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH
What is the function of this protein?
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest.  Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'.
What are the official names of this protein?
Cyclin-D-binding Myb-like transcription factor 1.
What is the protein family that this protein belongs to?
Belongs to the DMTF1 family.
What are the subcellular locations of this protein?
Nucleus.