PharMolix/UniProtQA huggingface dataset:
Protein: IMA6_HUMAN
Sequence: MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL
What is the function of this protein?
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1.  Binds specifically and directly to substrates containing either a simple or bipartite NLS motif.  Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9.  Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
What are the official names of this protein?
Importin subunit alpha-6, Karyopherin subunit alpha-5.
What is the protein family that this protein belongs to?
Belongs to the importin alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_SACEN
Sequence: MSTEQEPKTSPLTHLVALARDTVPPMHPAGRPFVLGAAVATLLLRRRWRGAGVLGGILTAWCAWFFREPRRTAPTRDGIAVAPADGTVAHVEKAVPPAELGLGAAPMTRVSVFLTIFDVHVQRVPLSGEVTKVSYRAGKFLSADLDKASEDNERNSMLIRGADGTEVAVVQIAGLVARRIVCSASEGDQVLAGHTYGLIRFGSRVDLYVPADSRVLVEPGQRTIGGETVIAELARA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KDSB_ESCF3
Sequence: MSFVVIIPARFASTRLPGKPLLDINGKPMIVHVLERARESGAERIIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCGFSDDTVIVNVQGDEPMIPAVIIRQVAENLAQRQVGMATLAAPVHSAEEAFNPNVVKVVLDSEGYALYFSRATIPWDRDRFAKGLETVGDNFLRHLGIYGYRAGFIRRYVNWQPSPLEHIEMLEQLRVLWYGEKIHVAVAEQVPGTGVDTAEDLERVRAEMR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_CHLT2
Sequence: MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSILIETVTNMYSFEEYRNLRFLKADDGQAGASNNRTGRNGKDLVLKVPEGTLLRDAATGELIHDFTKDGERIVVCQGGRGGKGNVFFKTSTNRAPTKATPGKPGEIRLVELELKLIADIGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLHPSLGLVHQEGMLYQKTWIMADIPGIIEGASQNRGLGLDFLRHIERTRLLLFVIDISGIERHSPEQDLKILMGELLAYKEELKDKDMVIALNKIDQLLPDEREERVALLKQQFPDQEFILLSGLTGEGVDALYDLFKSKLSE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EI24_BOVIN
Sequence: MADSVKTFLQDLARGIKDSIWGICTISKLDARIQQKREEQRRRRASSILAQRRAQSIERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFYRVFIPVLQSVTAQIIGDPSLHGDVWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIADLAFEVSGRKPHPFPSVSKIIADMLFNLLLQALFLLQGMFVSLFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIVSGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSTSAEKLPSPHPSPAKLKAATGR
What are the official names of this protein?
Etoposide-induced protein 2.4 homolog.
What is the protein family that this protein belongs to?
Belongs to the EI24 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NEU1_BALPH
Sequence: CYIQNCPLG
What is the function of this protein?
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.  Acts by binding to oxytocin receptor (OXTR) (By similarity).
What are the official names of this protein?
Oxytocin, Ocytocin.
What is the protein family that this protein belongs to?
Belongs to the vasopressin/oxytocin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPA_BACC0
Sequence: MSIRAEEISALIKQQIENYQSEIEVSDVGTVIQVGDGIARAHGLDNVMAGELVEFSNGVMGLAQNLEENNVGIIILGPYTEIREGDEVRRTGRIMQVPVGKELIGRVVNPLGQPVDGLGPINTTNTRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTAVALDTIINQKDEDMICIYVAIGQKESTVRNVVETLRKHGALEYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFIETQAGDVSAYIPTNVISITDGQIFLQSDLFFSGVRPAIDAGTSVSRVGGSAQIKAMSKVSGTLRLDLASYRELEAFAQFGSDLDKATQAKLNRGARTVEVLKQGLHKPLRVEKQVIILYALTRGFLDDIPVVDITRFEEEFHAWLDSNATDLLEEIRTTKKLADDDKFAAAINGFKKVFVASE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CCR4E_ARATH
Sequence: MSGYERKNTTANSITITKRKRNSISEQSENVYEKSNRKESITLKPHRSFTPGFSQRDCKPVRHSKSSLRRRRRTKEKISSSVEREWVFSANNFENLADKLVLVSYNLLGVDNASNHMDLYYNVPRKHLEWSRRKHLICKEISRYNASILCLQEVDRFDDLDVLLKNRGFRGVHKSRTGEASDGCAIFWKENLFELLDHQHIEFDKFGMRNNVAQLCVLEMNCEEDPKSKLRVRSSDPRRLVVGNIHVLFNPKRGDIKLGQVRLFLEKAYKLSQEWGNIPVAIAGDLNSTPQSAIYDFIASADLDTQLHDRRQISGQTEVEPKERSFRNHYAFSASASISGSLLNEWSQEELQLATGGQETTHVQHQLKLNSAYSGVPGTYRTRDQRGEPLATTYHSRFLGTVDYIWHTKELVPVRVLETLPADVLRRTGGLPSENWGSDHLAIACELGFVNDWQ
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
What are the official names of this protein?
Carbon catabolite repressor protein 4 homolog 5, CCR4 homolog 5.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: Y865_METJA
Sequence: MNKIKEGANVRITIYSPEVYTYGAMLIGGILKHKGYNVHLVRKIDKTLFLKSDVIIFSLYSTLHILDKNIREAIDFIKKVRKNKTKVYVAGCVSTYPEIILNELNVDGVIVGEGEITTPKIIEGDKEGLAYKEGDEIVINYPKEKPDLNHPLPLIPKDIEQQSIRGANVYIETHRGCLGNCTFCQVPKFFGKTIRSRDVEDVVEEVKAFKRAGAKRIAISGGTGSLYAFKKSINRDKFFELLEKVSEVIGKNNLSVPDMRVDYVDEEILEAIKNYTIGWVFYGIESGSDKILKDMKKGTNREKNLDAIKLAKDCGVKVAGSFIVAYPTETEMDYLLTKDFIVDAELDDVFVSIAEPIPTTELCDLVLSMPKEENLLYKMHEGEYRKLGLSEAEARCFDLLIHAEMWKSMPKPLTPQLYNLYLNEARIQGKDIRAITDLLFKYRDLLLKK
What are the official names of this protein?
Putative methylthiotransferase MJ0865.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family.
Protein: KUP_ECOHS
Sequence: MSTDNKQSLPAITLAAIGVVYGDIGTSPLYTLRECLSGQFGFGVERDAVFGFLSLIFWLLIFVVSIKYLTFVMRADNAGEGGILTLMSLAGRNTSARTTSMLVIMGLIGGSFFYGEVVITPAISVMSAIEGLEIVAPQLDTWIVPLSIIVLTLLFMIQKHGTAMVGKLFAPIMLTWFLILAGLGLRSIIANPEVLHALNPMWAVHFFLEYKTVSFIALGAVVLSITGVEALYADMGHFGKFPIRLAWFTVVLPSLTLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLIIAALATVIASQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPFVNWMLYVAVVIVIVSFEHSSNLAAAYGIAVTGTMVLTSILSTTVARQNWHWNKYFVALILIAFLCVDIPLFTANLDKLLSGGWLPLSLGTVMFIVMTTWKSERFRLLRRMHEHGNSLEAMIASLEKSPPVRVPGTAVYMSRAINVIPFALMHNLKHNKVLHERVILLTLRTEDAPYVHNVRRVQIEQLSPTFWRVVASYGWRETPNVEEVFHRCGLEGLSCRMMETSFFMSHESLILGKRPWYLRLRGKLYLLLQRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PAND_CLOBA
Sequence: MILNMLKGKIHRATVTQADLNYMGSITIDKTLIDAAGILENEKVQIVDNNNGARLETYVIPGKRDSGIICLNGAAARLVQPGDEIIIIAYAQIIESEAKTYKPKVVFVNDDNTIKEITNYEFNE
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FENR_POPEU
Sequence: DPNATIIMLGTGTGIAPFR
What is the function of this protein?
May play a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power.
What are the official names of this protein?
Ferredoxin--NADP reductase, chloroplastic, FNR.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=In the vicinity of the photosystem I in the non-stacked and fringe portion of the membrane.
Protein: ERYD_BRUA2
Sequence: MADADDSLALRAAWLHFVAGMTQSAVAKRLGLPSVKAHRLIAKAVADGAVKVTIDGDITECIDLENRLADLYGLDYCEVAPDIGEEGLPLMALGHAGANFMRREIEHGDHEVIGIGHGRTLSAAVGYMPRVMANDLRFVSLLGGLTRNFAANPHDVMHRIAEKTGMPAYVMPVPFFANTAEDREVLLAQRGVTTVFDMGCRAELKIVGIGTVDAQAQLVTSGMIELGEVEEIANLGGVGEMLGHFFNANGQWLETALTGRTIAASVENADMSRIVALAGGLSKVDAIRAVLKSGRLYGLITDERTAKALIGQPNGK
What is the function of this protein?
Represses the expression of the eryABCD operon, which is involved in erythritol catabolism.
What are the official names of this protein?
Erythritol catabolism regulatory protein EryD.
What is the protein family that this protein belongs to?
Belongs to the SorC transcriptional regulatory family.
Protein: HSCB_BURMA
Sequence: MVSLKDSHFDLFHLPARFALDEPTLDAAYRAVQSQVHPDRFAAAGDAQKRIAMQWATRANEAYQTLRDPLKRATYLLHLRGVDVGAENNTAMEPAFLMQQMEWRERIEDAAGAKNVDALDALLAELRDERRARLAKLGALLDSGSDQGAAEAVRQLMFVERVSAEIGAQIERLEH
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: Y960_HAEIN
Sequence: MKKYFLILASFMLVACSSSEQNLTYSTKPILNITSSLSPLIQVETTQKSAVIKNKSQQLLNISYHLYWYDHLGVTQIWENQQESYSAQFLLKPQEQKSIDLTKPTVESKNYRLYLK
What are the official names of this protein?
Uncharacterized protein HI_0960.
Protein: PFKA_ALKOO
Sequence: MKKIAVLTSGGDAPGMNAAVRAVVRSGIYNEMKVMGVKQGYNGLINAQIEEMNLSSVADIIHRGGTILRTARSEEFMTEEGQRKALNVIKVLGIEGIVAIGGDGSIRGAKTLNELGIPTIGVPGTIDNDLAYTDYTIGFDTSVNTVVDAISKIRDTSTSHGRANIIEVMGRHCGDIALMAGLAGGAESIIVPEVGVDVDEVCNKLLKGRYRGKLHSIIILAEGAGSAIEMSKEIEEKTGIETRATILGHLQRGGSPTASDRILASKLGARAVELLLQDIGNRVVGVHGKNVIDMDIDEALSMKSNFDIETYELTKILSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_SALTI
Sequence: MARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGRR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PPCE_RAT
Sequence: MLSFQYPDVYRDETSVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNTLSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFTCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDVLCAEFPDEPKWMGGAELSDDGRYVLLSIWEGCDPVNRLWYCDLQQGSNGINGILKWVKLIDNFEGEYDYITNEGTVFTFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLRNVKNILQLHDLTTGALLKTFPLDVGSVVGYSGRKKDSEIFYQFTSFLSPGVIYHCDLTREELEPRVFREVTVKGIDASDYQTIQVFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTTSKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYGCSDSKQHFEWLLKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGPGKPTAKVIEEVSDMFAFIARCLNIEWIQ
What is the function of this protein?
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.  Has high activity on the succinyl- (suc-) peptide-4-methylcoumaryl-7-amide (MCA) substrates suc-Gly-Pro-Leu-Gly-Pro-MCA, suc-Gly-Pro-MCA and suc-Ala-Ala-Ala-MCA.
What are the official names of this protein?
Prolyl endopeptidase, PE, Post-proline cleaving enzyme, rPop.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXS_BACAA
Sequence: MTNVTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAIMALERVPADIRAAGGVSRMADPTIVEEVMGAVSIPVMAKCRIGHLVEARVLESLGVDYIDESEVLTPADEVYHLNKRDYTVPFVCGCRDIGEAARRIAEGASMLRTKGEPGTGNIVEAVRHMRQVNAEIRQVASLREDELMTYAKNTGAPYEVLLEIKRLGRLPVVNFAAGGVATPADAALMMQLGADGVFVGSGIFKSENPAKFARAIVEATTHYEDYELIASLSKGLGNAMKGIEISTLLPEQRMQERGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: GAK5_HUMAN
Sequence: MGQTKSKTKSKYASYLSFIKILLKRGGVRVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDWKRIGEELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTKEDSVSVSDAPGSCVIDCNEKTGRKSQKETESLHCEYVTEPVMAQSTQNVDYNQLQGVIYPETLKLEGKGPELVGPSESKPRGPSPLPAGQVPVTLQPQTQVKENKTQPPVAYQYWPPAELQYLPPPESQYGYPGMPPALQGRAPYPQPPTVRLNPTASRSGQGGTLHAVIDEARKQGDLEAWRFLVILQLVQAGEETQVGAPARAETRCEPFTMKMLKDIKEGVKQYGSNSPYIRTLLDSIAHGNRLTPYDWESLAKSSLSSSQYLQFKTWWIDGVQEQVRKNQATKPTVNIDADQLLGTGPNWSTINQQSVMQNEAIEQVRAICLRAWGKIQDPGTAFPINSIRQGSKEPYPDFVARLQDAAQKSITDDNARKVIVELMAYENANPECQSAIKPLKGKVPAGVDVITEYVKACDGIGGAMHKAMLMAQAMRGLTLGGQVRTFGKKCYNCGQIGHLKRSCPVLNKQNIINQAITAKNKKPSGLCPKCGKGKHWANQCHSKFDKDGQPLSGNRKRGQPQAPQQTGAFPVQLFVPQGFQGQQPLQKIPPLQGVSQLQQSNSCPAPQQAAPQ
What is the function of this protein?
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle.  During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell.  Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA.  Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
What are the official names of this protein?
Endogenous retrovirus group K member 5 Gag polyprotein, HERV-K(II) Gag protein, HERV-K_3q12.3 provirus ancestral Gag polyprotein, Gag polyprotein.
What is the protein family that this protein belongs to?
Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system).
Protein: GCH4_PSYIN
Sequence: MPDIANSAQAQTEGKLDRVGMSNIELPLMVQTDDCPPQQVSANAEVFVNLGDAQAKGIHMSRLYLQLDELSTESELNISTLTALLQGFITSHHELSQRAFVKFSFDYHLRRKSLISEKRGWKAYPVIIIGRLSEGNFEVELQVNVPYSSTCPCSAALARQLIQQAFSQKYDQQTEVNKEEIFAWLGSTKGIVATPHSQRSIVEVKVKLNSLNQSFPIIELIDLIEKTLKTPVQAAVKREDEQEFALLNGQNLMFCEDAARHLQHSLHQETKFDDFWLRVNHYESLHAHDAVAMTTKGIEGGYLA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: EFG_STRGC
Sequence: MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAHPIQLPIGAEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLEQAQEYREKLVEAVAETDEDLMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVIDYLPSPLDIPAIKGINPDTDEEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLQSGSYVLNTSKGKRERIGRILQMHANSRQEIETVYAGDIAAAVGLKDTTTGDSLTDEKAKIILESINVPEPVIQLMVEPKSKADQDKMGVALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPIVDVKAKLYDGSYHDVDSSETAFKVAASLALKEAAKTAQPAILEPMMLVTITVPEENLGDVMGHVTARRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQEEIIKKHKGEA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA2_CLOBL
Sequence: MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNINSIKKADEGKFTLGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDAIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACDLVTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKMGYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVDHGTAFDIAGTGQASSVSMVEAIVLAAKYSPKFKK
What is the function of this protein?
Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).
What are the official names of this protein?
Putative D-threonate 4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family. PdxA2 subfamily.
Protein: SSL11_STAAE
Sequence: MKLKNIAKASLALGILTTGMITTTAQPVKASTLEVRSQATQDLSEYYNRPFFEYTNQSGYKEEGKVTFTPNYQLIDVTLTGNEKQNFGEDISNVDIFVVRENSDRSGNTASIGGITKTNGSNYIDKVKDVNLIITKNIDSVTSTSTSSTYTINKEEISLKELDFKLRKHLIDKHNLYKTEPKDSKIRITMKDGGFYTFELNKKLQTHRMGDVIDGRNIEKIEVNL
What is the function of this protein?
Secreted protein that plays a role in the inhibition of host immune system.  Targets myeloid cells such as monocytes or granulocytes through binding with sialyllactosamine-containing glycoproteins.  Prevents initial rolling of neutrophils toward the site of infection by interacting with host SELPLG.  Disrupts neutrophil motility by induction of cell adhesion via interacting with glycans but independently of SELPLG.
What are the official names of this protein?
Superantigen-like protein 11.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal/streptococcal toxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y070_ARCFU
Sequence: MQVMNRYFLPKTGWEFFDVSRAYGVGVIVHTLSGDAVVSDMGGLYLIESQRELNFERIDQIHKFFGDDQAWDWTFITIGSGQREKTKKKVVEFLGNVEDIRNILDGLKELKSPVYIGSGKETLYQPMELAATKGIRDEILLKKQYSEGSPVKVSISDFTLSVLGHINATIRKFSNMGMIFAIPSPTRTRILHLIGEIRKRIDDSVKGLHRAGWFPSLAQIAVNLVLEELRVEEGGKFAPKFGSLIYGVMTKTGNQWKPLTGGIFPLDLLHQIAESNEAIKVLNKWKDIFEWTAFRKGYEDLPSALAEFITNPSLSNYERYIKLHLRNDIGKDRIKFGSYEEKVLKEVVNFVGV
What are the official names of this protein?
Uncharacterized protein AF_0070.
Protein: TRIM5_PLEDO
Sequence: MASRILVNIKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKESTLHQGERSCPLCRISYPSENLRPNRHLANIVERLREVVLSPEEGQKVDLCARHGEKLLLFCQQDGNVICWLCERSQEHRGHHTFLVEEVAQTYRENLQVVLEMMRQKHQDAEKLEADVREEQASWKIQIQNDKTNIMAEFKQLRDILDCEESNELQNLEKEEKNILKRLVQSENDMVLQTQSISVLISDLEHRLQGSVMELLQGVDGVIKRVKNVTLQKPKTFLNEKRRVFRVPDLKGMLQVSKELTEVQRYWAHVTLVASHPSRAVISEDERQVRYQEWIHQSSGRVKYFYGVLGSPSITSGKHYWEVDVSNKSAWILGVCVSLKCAANRNGPGVENYQPKNGYWVIGLRNADNYSAFQDSVKYNDFQDGSRSTTYAPLIVPLFMTICPNRVGVFLDYEACTVSFFNVTSNGFLIYKFSNCHFSYPVFPYFSPMTCELPMTLCSPRS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.