PharMolix/UniProtQA huggingface dataset:
Protein: RL14_SHIF8
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: GNB1L_DICDI
Sequence: MNKEASNNNNSAPDPYYILRGHKFNVNSVLFDKVNPNLLYSGSGDGELKLWNIEEKKCISTQIAHSEGIGGGVLSLQWLSNDNNNENNNNNDEICGNILSQGRDGVIKIWSIIDNCTFKNTYRLETNSLSLGKCSSLSSNLLSISGSAIDPTSSTSQVEIWDLKNKQVINKLKPNNQQLFEKLGLPMSLKLYYENENNDNSNQSNDQIRLCTGYENGELLIWDLRNTSIPLVSSKLHNEPILSFALSNNSTKGISGSGDTNIIEFNINYESKQFNITKTHKLNNGGISEIKIRNDEKIYATAGWDKRIRIFNFKKQTPLAILKYHTESVYSIDFNSNNILASGSKDCKIALWDIYTTKK
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-like protein 1 homolog.
Protein: NU3M_MICPE
Sequence: MNMMLILLMNIALAAILISLAFWLPHLNVYTEKANPYECGFDPMSSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAMQFPNMNMLMTMAFILITILALGLAYEWTQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AURB_CALAK
Sequence: MTKESADNYYNPLMLWGYDVFVQVLTNSFWWRCSTKGILVPFFLDNSTTNHMEVGAGTGYFLRAKLDHERSKLKSSDDKTLWPQNLTLVDFHERCMNKAANRISPVRPNRVLANIMEPIPLKGQKFDSIAIMYVLHCIAATPEAKGRVFANLKPFLADEGTLFGSTVLGKGVKHNLIGGFLMWLYNYIGMFDNWDDGKEDFLKPLREHFEVVESEVVGTVLLFKAEKPRH
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of aurovertins, fungal polyketides that exhibit potent inhibition of adenosine triphosphate synthase (PubMed:26340065).  Tha biosynthesis starts with the HR-PKS aurA that selects propionate as the starter unit; synthesizes a hexa-ene chain through the repeated functions of the KR and DH domains in the first six iterations; selectively introduces three alpha-methyl substitutions at C4, C6, and C16 using the S-adensylmethionine-dependent cMET; and shuts off KR and DH in the last three iterations to afford a 1,3,5-triketo portion that can undergo intramolecular cyclization to yield the alpha-pyrone intermediate (PubMed:26340065).  AurE may act as a cyclase and enhances the rate of pyrone formation and product release of aurA (PubMed:26340065).  The methyltransferase aurB then methylates the C17 hydroxyl group (PubMed:26340065).  C17 methylation is required to initiate epoxidation by the downstream monooxygenase aurC (PubMed:26340065).  The monooxygenase aurC and the epoxide hydrolase aurD can iteratively transform the terminal triene portion of the methylated precursor into the dioxabicyclo[3. 2. 1]octane scaffold of aurovertin E.  Epoxidation modifications of the precursor occur in two separate steps; bis-epoxidation of the two terminal olefins takes place first, followed by another epoxidation that occurs at C7-C8 after tetrahydrofuran formation (PubMed:26340065).  The O-acyltransferase aurG converts aurovertin E to aurovertin A (PubMed:26340065).
What are the official names of this protein?
Methyltransferase aurB, Aurovertin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: YR563_MIMIV
Sequence: MSSRLSYVNVDDPNFYEFIDEKYSKYKIPPKQKTFKQFCFPSKYEFQIPQQFLAEYINPKTPYKGLLIYHRIGAGKTCTAIKIAENFKNKSKIMIVVPASLKGNFRSELRSLCADDHYLTSKERSELKILHPSSDEYKSIIKVSDDRIDKYYTIYSYNKFVDLIKQNKINLTNTLLIIDEVHNMISETGTYYESLYETIHSAPDNMRLVIMTATPIFDKPNEIALTMNLLVRNKQLPVGPDFVSTFMDIRYNSKGPVYHVKNMDLFKEFVKGYVSYYRGAPPYVFPKSELFFVRTKMSDLQKTVYQKITGKEVKQTKVRDYVNENISNNFFIGTRMISNIVYPNEKVGLKGYNSLTDEDLTIAKIREYSPKFLKILRKIKRCNGTVFVYSNFKEYGGIRVFARLLEFHRFKNYEFNGSGPRRFAIWSGDQDPIYKEEVKAVFNNKDNEFGSKIKVILGSSSIKEGVSFLRVQEVHIMEPYWNFSRMEQIIGRAIRFCSHKDVELDRQLVKVYIYLAVHPDIKMSIDERMMKMALDKKMINSAFEKALKEAAIDCELFKNANVYPGEQDIQCEQ
What are the official names of this protein?
Putative ATP-dependent RNA helicase R563.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Virion.
Protein: SCPA_LIGS1
Sequence: MAQENKQNSRTAEHLTFKLDQFEGPLDLLLHLIKQNEMDIYDIQVAEITSQYIDYLHQMQDLRLDIAGEYLVIAATLLNIKSKMLLPVEQEQQVEEDYVDPREDLVQQLVSHQLYQEVAAKFHVMEKQRMELFSREQAVNEDVTYEVSEGTTIDLLQKAFAKLMARKKVKKIKKIKRKIIPERYTIKEEIENIEHTLKMHKGTMNFTDLFDFDGEVEVEKVVTSFLALLELVRVGRVSASQEENNGPILMTYEGKAEEDAI
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: RL4_BACAH
Sequence: MPKVTVYNQTGSQVGEIELAEAIFGIEPNEAVLFEAVMMQRASLRQGTHKVKTRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGTVFGPTPRSYAYKLPKKVRRLAIKSALATKVVENNIVVLEDLVLNAPKTKDMLAVLKGLTVEKKALIVTADANESVELSARNIPGVTVITADGVNVLDVLHHDKLIMTKAAVEKVEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NU3M_CERSI
Sequence: MNLMLTLFINTSLASVLVLIAFWLPQLNIYTEKASPYECGFDPMGSARLPFTMKFFLVAITFLLFDLEIALLLPLPWASQTTNLKTMLTMALILISLLAASLAYEWTQKGLEWAE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ILVC_MARMS
Sequence: MANYFNTLPLREQLAQLAKCRFMDSSEFADGVEALKGKKMVVIGCGAQGLNQGLNLRDSGLDVSYALRPEAIAQKRQSWKNATENGFVVGTYEELIPTADVVLNLTPDKQHTPVVKAVMPLMKEGACLSYSHGFNIVEEGMQIREDLTVIMVAPKCPGSEVRAEYVRGFGVPTLIAVHEDNDPKGEGLALAKAYAVGTGGHKAGVLMSSFIAEVKSDLMGEQTILCGMLQTGSILCFDKMVEEGIDAGYASRLIQYGWETITEALKYGGVTNMLDRLSNPAKIKAFDLSEELKVIMRPLYNKHQDDIISGHFSQTMMEDWANDDKNLLQWRADTAETNFEKTPAGDVEISEQEFFDNGILMVAMVKAGVELAFETMTAAGIIAESAYYESLHETPLIANTIARKKLYEMNATISDTAEYGCYLYNHACVPLLADFMKDIKTDVIGKGLSVEDNGVDNARLIEVNKALRSHPVEAVGAVLRGHMADMKKIV
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RHAR_CROS8
Sequence: MASQLVLRKADFFATPTQPVVVADRYPQNVFAEHTHEFCELVLVWRGNGLHVLNDRPYRITCGDLFYIRAEDRHSYQSVNDLVLHNIIYCPERLQLNVNWRDLLENPRGVNGDPRWRLSSQGMVQARQVIDQLEHESPKQDALSHCLAESLFLQLAITLRRHRYQPSGGTGPGEGETLDLLMAALGNSLDVPFDLQHFCSHYQIAERPLRQLFRQQTGMTISQYLRQLRICQAQYLLRHSSLLISEIAARCGFEDSNYFSVVFTRETGVTPRVWRQQWGALAG
What is the function of this protein?
Activates expression of the rhaSR operon in response to L-rhamnose.
What are the official names of this protein?
HTH-type transcriptional activator RhaR, L-rhamnose operon transcriptional activator RhaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSR_ECOLI
Sequence: MADVHDKATRSKNMRAIATRDTAIEKRLASLLTGQGLAFRVQDASLPGRPDFVVDEYRCVIFTHGCFWHHHHCYLFKVPATRTEFWLEKIGKNVERDRRDISRLQELGWRVLIVWECALRGREKLTDEALTERLEEWICGEGASAQIDTQGIHLLA
What is the function of this protein?
Deamination of 5-methylcytosine in DNA results in T/G mismatches.  If unrepaired, these mismatches can lead to C-to-T transition mutations.  The very short patch (VSP) repair process in E. coli counteracts the mutagenic process by repairing the mismatches in favor of the G-containing strand.  This enzyme is an endonuclease that nicks double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the thymidine residue that is mismatched to 2'-deoxyguanosine.  The incision is mismatch-dependent and strand-specific.
What are the official names of this protein?
DNA mismatch endonuclease Vsr, Type II nicking enzyme, V.EcoKDcm, Very short patch repair protein, Vsr mismatch endonuclease.
What is the protein family that this protein belongs to?
Belongs to the Vsr family.
Protein: ENGB_NATPD
Sequence: MFETRPNRADEIVLVGRSNVGKSTLMREITGHDSFATGGSPGVTTKPNHYDWAGDDFVITDLPGFGFMSGVPEDVRESIKRDVVQYIEAHADNILAGILVVDGKAVVDIIDRHSGPDEIPHDVEMFGFLQELGIPTVVAVNKMDKVDDRDERLDELAERLGLYPPWQQFDEMLAPISAKRGSIEPLNQAVRHHLHEQKRDDLFKFF
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: ALG9_ARATH
Sequence: MDLTTTRQRRPLISDSSSSSSTKSYSKTDKPGRSNGGDAEDGGLRWFLPFIALCYLRYMSATSNIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALRSYLYILFHELAGRPASWWFGDDKVRVFYAVRLFLGLVSAVSDTVLVVALSRKYGKRIATYAVAMLCLTSGCFFASTSFLPSSFSMYAISLSSGLLLFEKYAMAVAVSVVGVILGWPFSILAFLPVVIYSLVKRFKQAFIAGAVTTIFLLGVSLLVDYYYYKRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFNFCFILAMLFVAIYPVIRRKYDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLICVSASAVIENIPELFREKYSSRESLLVTITKYMRPVILGCILCASHSRTFALINGYSAPLEVYKLLEHHDDAGPGSVLCVGSEWHRYPSSFFVPHYISEVRWIDDGFRGLLPFPFNNTLGGTSASPPYFNNKNQASEEQYLKNIETCTFLIELQLSRPYQYRGSDLSTWEAIAVLPYLDRELSPAKYRSFFIPHMWQEKNVFGKYVALRRVPK
What is the function of this protein?
Required for N-linked oligosaccharide assembly.  Adds the seventh and the ninth mannose residues in an alpha-1,2 linkage onto the dolichol-PP-oligosaccharide precursors dolichol-PP-Man(6)GlcNAc(2) and dolichol-PP-Man(8)GlcNAc(2).
What are the official names of this protein?
Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase, Alpha-1,2-mannosyltransferase ALG9, Asparagine-linked glycosylation protein 9, Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: AROA_VIBCH
Sequence: MESLTLQPIELISGEVNLPGSKSVSNRALLLAALASGTTRLTNLLDSDDIRHMLNALTKLGVNYRLSADKTTCEVEGLGQAFHTTQPLELFLGNAGTAMRPLAAALCLGQGDYVLTGEPRMKERPIGHLVDALRQAGAQIEYLEQENFPPLRIQGTGLQAGTVTIDGSISSQFLTAFLMSAPLAQGKVTIKIVGELVSKPYIDITLHIMEQFGVQVINHDYQEFVIPAGQSYVSPGQFLVEGDASSASYFLAAAAIKGGEVKVTGIGKNSIQGDIQFADALEKMGAQIEWGDDYVIARRGELNAVDLDFNHIPDAAMTIATTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGATVEEGEDFIVITPPTKLIHAAIDTYDDHRMAMCFSLVALSDTPVTINDPKCTSKTFPDYFDKFAQLSR
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTG8_MOUSE
Sequence: MPDRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAPQQGDTPAVSSSVTPSSGAGSPMDTPPAATPRSTTPGTPSTIETTPR
What is the function of this protein?
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes.  Can repress the expression of MMP7 in a ZBTB33-dependent manner.  Can repress transactivation mediated by TCF12 (By similarity).  Acts as a negative regulator of adipogenesis (PubMed:23527555).
What are the official names of this protein?
Protein CBFA2T1, Protein MTG8.
What is the protein family that this protein belongs to?
Belongs to the CBFA2T family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with ATN1 in discrete nuclear dots.
Protein: PLSX_ENT38
Sequence: MTRLTLALDVMGGDFGPSVTVPAALQALNSNSQLTLLLVGNPDTITPLLAKADFEQRSRLQIIPAQSVIASDARPSHAIRNSRGTSMRIALELVKEGRAEACVSAGNTGALMGLAKLMLKPIQGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLAQFAIMGSVLAEEVVGISNPRVALLNIGEEETKGLDSIREAAELLKSAPSINYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKTAWWLILLKRWLQKSLTRRFSHLNPDQYNGACLLGLRGTVIKSHGAANQRAFTVAIEQAVQAVQRQVPQRIAARLESVLAKSD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: Y0003_DICDI
Sequence: MLFKSLQSISSVSSVQKNQISSISVGSTQSNNNAALLDAAALVVIPGLLTAAAVAHI
What are the official names of this protein?
Uncharacterized transmembrane protein DDB_G0286193.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ACP_CHLTR
Sequence: MSLEDDVKAIIVDQLGVSPEDVKVDSSFIEDLNADSLDLTELIMTLEEKFAFEISEDDAEQLRTVGDVIKYIQERQN
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOPZ1_HUMAN
Sequence: MRRPPPLGPTTASGPEGNVRNLQKRQAPGPGAAGGCGPEAGGCRENKQKRRMVARATPGRGEVESDKSVAASGAGKAARRQVEGRRGPVSPSDSSDPRGLEAAKEAELPLQTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQSLGKESIIEGIKRRIRNKKLKSLENPPLKITENEATQNIKVEFQDELYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEELSRRGSEVISNTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATSKDGQEANNSAGKTIHRKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNAKSSEREAYSPLELLDNLSGADVRQNRSKENVSMMMLGPQTLSIRNSVTPVQASSDSFYNKKSYSISPSFTKQGNNSKPSNHVSEPGNIVSNKEVASLTVENNAFSCDPGYVEKSPSFCCNEQETFRPVSSEVRGRKITKNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSFTSEVPKISQEPNVAGEHQSTDSKYMETPVKKEPSDDLRELPVLDCGWIKPDICASNSAESEIKRDPKDVNTSLGEVANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVCKSKDSRNADFMVGECQFAVPVPKPLCLLVPPLNLSGRQEDTILNTWMNDFRFLGKHSVLKLQNPETCEIFKREKNVGVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELCLLQRAVNIFMEYYRKFPPGVYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLKILLNIFEYVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAVLEMKSRLQMRRFKKNWKCDLDSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSKGRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMRESEWIINTPLWPCDRLDVLNRHNLLCTIAHEILAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSLLFNKLLGSCIESSSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSRLWLKARAHYKSALSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKRCEDNQSRSNDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENMKWAGKVWLFSNH
What is the function of this protein?
Important for normal spermatogenesis and male fertility.  Specifically required for progression to the post-meiotic stages of spermatocyte development.  Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
What are the official names of this protein?
Protein TOPAZ1, Testis- and ovary-specific PAZ domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MRC2_MOUSE
Sequence: MVPIRPALAPWPRHLLRCVLLLGGLRLGHPADSAAALLEPDVFLIFSQGMQGCLEAQGVQVRVTPVCNASLPAQRWKWVSRNRLFNLGATQCLGTGWPVTNTTVSLGMYECDREALSLRWQCRTLGDQLSLLLGARASNASKPGTLERGDQTRSGHWNIYGSEEDLCARPYYEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPGEENCGVIRTESSGGWQNHDCSIALPYVCKKKPNATVEPIQPDRWTNVKVECDPSWQPFQGHCYRLQAEKRSWQESKRACLRGGGDLLSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGRLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVIYSDARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFRWLSGDEVIYTHWNRDQPGYRRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWVSDPKLRHCYKVFSSERLQEKKSWIQALGVCRELGAQLLSLASYEEEHFVAHMLNKIFGESEPESHEQHWFWIGLNRRDPREGHSWRWSDGLGFSYHNFARSRHDDDDIRGCAVLDLASLQWVPMQCQTQLDWICKIPRGVDVREPDIGRQGRLEWVRFQEAEYKFFEHHSSWAQAQRICTWFQADLTSVHSQAELDFLGQNLQKLSSDQEQHWWIGLHTLESDGRFRWTDGSIINFISWAPGKPRPIGKDKKCVYMTARQEDWGDQRCHTALPYICKRSNSSGETQPQDLPPSALGGCPSGWNQFLNKCFRIQGQDPQDRVKWSEAQFSCEQQEAQLVTIANPLEQAFITASLPNVTFDLWIGLHASQRDFQWIEQEPLLYTNWAPGEPSGPSPAPSGTKPTSCAVILHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAATPPAPGAELSYLNHTFRLLQKPLRWKDALLLCESRNASLAHVPDPYTQAFLTQAARGLQTPLWIGLASEEGSRRYSWLSEEPLNYVSWQDEEPQHSGGCAYVDVDGTWRTTSCDTKLQGAVCGVSRGPPPRRINYRGSCPQGLADSSWIPFREHCYSFHMEVLLGHKEALQRCQKAGGTVLSILDEMENVFVWEHLQTAEAQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSSSGLWRPGACTNITMGVVCKLPRVEENSFLPSAALPESPVALVVVLTAVLLLLALMTAALILYRRRQSAERGSFEGARYSRSSHSGPAEATEKNILVSDMEMNEQQE
What is the function of this protein?
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity.  Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis.  May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface.  May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices.  May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
What are the official names of this protein?
C-type mannose receptor 2, Lectin lambda, Macrophage mannose receptor 2.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: NU3C_SYNSC
Sequence: MFALPGYDAFLGFLLIAAAVPVLALVTNKLVAPKSRAGERQLTYESGMEPIGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFNRLGLLAFIEALIFIAILLVALAYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: CP9H1_DROME
Sequence: MDQSMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDYFSSLVTAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGHALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNGFWLKFEARQ
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 9h1, CYPIXH1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: XPR1_MUSMC
Sequence: MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDVQKESSAVTALRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVIHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTIFRVGLFCGIFIVLNITLVFAAVFKLETDRTVWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGILWCLSLLACFFAPISIIPIYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLAGQLNSLSVILMDLEYMICFYSFELKWDESKGLLPNDPQEPEFCHKYSYGVRAIVQCIPAWLRFIQCLRRYRDTRRAFPHLVNAGKYSTTFFTVTFAALYSTHKEQNHSDTVVFFYLWVFFCIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWIIQISITAHVGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQEDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT
What is the function of this protein?
Plays a role in phosphate homeostasis.  Mediates phosphate export from the cell.  Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.
What are the official names of this protein?
Xenotropic and polytropic retrovirus receptor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SYG1 (TC 2.A.94) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.