PharMolix/UniProtQA huggingface dataset:
Protein: NIKR_BRUAB
Sequence: MQRITITIDDDLMAALDRMIEIKGYQNRSEALRDLARTGLQQASLEEGQMEACVGVLSYTYDHSARDLSKKLTNTHHDHHNISVASMHVHLDHDRCLEVSILKGKTDDVRHFADHVKAERHVTHGTLAVLPL
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel (By similarity).
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: CAHH_VACCT
Sequence: MPQQLSPINIETKKAISNARLKPLDIHYNESKPTTIQNTGKLVRINFKGGYISGGFLPNEYVLSSLHIYWGKEDDYGSNHLIDVYKYSGEINLVHWNKKKYSSYEEAKKHDDGLIIISIFLQVSDHKNVYFQKIVNQLDSIRSANTSAPFDSVFYLDNLLPSKLDYFTYLGTTINHSADAVWIIFPTPINIHSDQLSKFRTLLSSSNHEGKPHYITENYRNPYKLNDDTQVYYSGEIIRAATTPPARENYFMRWLSDLRETCFSYYQKYIEENKTFAIIAIVFVFILTAILFFMSRRYSREKQN
What is the function of this protein?
Binds to chondroitin sulfate on the cell surface to provide virion attachment to target cell.
What are the official names of this protein?
Cell surface-binding protein OPG105, Carbonic anhydrase homolog.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Virion membrane. Note=Component of the mature virion (MV) membrane.
Protein: TCTP_SOLTU
Sequence: MLVYQDLLTGDELLSDSFPYKEIQNGMLWEVQGKWVVQGAVDVNIGANPSAEGGGEDEGVDDQAVKVVDIVDTFRLQEQPAFDKKQFVTYIKRYIKNLTPKLEGEAQEAFKKNIESATKFLLSKLKDFQFFVGEGMHDDSALVFAYYKDGSADPTFLYLAPGLKEIKC
What is the function of this protein?
Involved in calcium binding and microtubule stabilization.
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP, p23.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSM1_CANTT
Sequence: MTKKLTPQEKQNRKPAVRACVFCHQKHLQCSNERPCKNCVKRNIGHECRDIVRKRVQYLTGNGKGSSSKTKTPRKKLKSTPITASSPSVASTISPLPIDAGLKQEFSTPNEIPMSEPSLTNQPLSMSPLNPQGANNITNNFNSHATSQQIKEILEVPPHVNSMMNNSGLNTNVSLTPETLMIPDHLQFHTTTMLNTTNDVLNKLLTDQFETESLISANNSNNTSHNDNFIAQNNNNNPEPSNLHNRHQFSSNYLNEEYLMLGDILLHSKPVSPSPSNTSASEYNTNTLSPTNFGFIQNIDFEGFNQPKKKVAKKLKESRPFISLGYTDDSTLRLNHAPEANGQTEDLLDHNKDDSRKNPGNGNSIINFETKYVKDYVAPFITNGLYQSVKDIYSYQIINYEYPDSYHALTKFLKERFGGNDLSIDERKEKRSKLLVILKLIASYRPTFIAAHKSLLKPQDLLFLEMSLQRSLLDYKKLVELSSSPSIMWRRTGEIIYITEEMGLLLGYSPIEILEKRFFLFSLMPDEEIIRYFKFFKNIAVNDLQSSISIKVKLINKEGRLVEFCSVYTIKRDIFDIPMLIVGQFLPVM
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.
What are the official names of this protein?
Glucose starvation modulator protein 1.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS2_BACMK
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQKTVKKVEEAYRTMRDIAAEGGDILFVGTKKQAQEAIKEEATRAGMYFVNQRWLGGTLTNFQTIQKRIKRLKDIERMQEDGTFEVLPKKEVVQLKKELERLEKFLGGIKDMKGLPSALFIVDPRKERIAVAEARKLHIPIIGIVDTNCDPDEIDHVIPANDDAIRAVKLLTSKMADAILETKQGEETVTA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: TYSY_BACFN
Sequence: MKQYLDLLDRVLTEGIEKGDRTGTGTISVFGHQMRFNLDEGFPCLTTKKLHLKSIIYELLWFLKGDTNVKYLQDHGVRIWNEWADETGDLGHIYGYQWRSWPTYDGGFIDQISEAVDAIKHNPDSRRIIVSAWNVGDLDHMNLPPCHAFFQFYVANGRLSLQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLQAGDFIHTLGDAHIYLNHLEQVKLQLSREPRPLPQMKINPDVKNIFDFQFEDFELVNYDPHPHIAGKVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAZF_STAAW
Sequence: MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRTLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis.  It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA.  Neutralized by coexpression with cognate antitoxin MazE.
What are the official names of this protein?
Endoribonuclease MazF, Toxin MazF, mRNA interferase MazF.
What is the protein family that this protein belongs to?
Belongs to the PemK/MazF family.
Protein: PTH_SALTY
Sequence: MAIKLIVGLANPGAEYAATRHNAGAWYVDLLAERLRAPLREEPKFFGYTSRITLEGEDVRLLVPTTFMNLSGKAVGAMASFYRIQPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRVGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTELWFKEGLAKATSRLHTFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.  Involved in lambda inhibition of host protein synthesis.  PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death (By similarity).
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOA_SALG2
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPNTQVYDLGCSLGAATLSVRRNIRHEHCRIIAVDNSPAMIERCRRHIDAYKAPTPVEVVEGDIRDITIENASMVVLNFTLQFLEPAERQALLDKIYLGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLRKAGFEHSELWFQCFNFGSLVALKAGVAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: BACE_BACSU
Sequence: MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSGVIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALLFITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVELAVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTMITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLTYFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFSVAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKGVF
What is the function of this protein?
Part of the bacilysin biosynthesis operon.  May be involved in self-resistance to bacilysin by permitting efflux of this antibiotic.
What are the official names of this protein?
Putative bacilysin exporter BacE.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYC_SHESW
Sequence: MPMLKIYNSITRQKQEFKPINPGKIGMYVCGVTIYDLCHIGHGRTFVSFDMIVRYLRYVGYEVNFQRNITDVDDKIIKRANENNESCEALTERLIGEMHRDFDALNMLRPDFEPRATLHIAEIIDMVELLLARGHAYVASDGDVLFSVASYPDYGRLSGQNLDQLQAGARVEVDENKQNPMDFVLWKMSKPGEPTWESPWGPGRPGWHIECSAMNSKHLGLHFDIHGGGSDLQFPHHENEIAQSCCAHDTPYVNYWMHTGMVMVDREKMSKSLGNFFTIRDVLGHYDAETVRYFLLSGHYRSQLNYSEDNLKQARSALERLYTAIKDVDLTVAAAPAEEFIVKFKAAMDDDFNTPEAYSVLFDMVRDINRLKATDIAKASALAVAMKQLADVLGLLGQDPDAFFKGEGSDDEVAEIEALIVERNRARSEKDWPAADVARNRLNELGVVLEDGPSGTTWRKK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AURE_CALAK
Sequence: MSTSCSNPDDQVKARNDKFMAALNDATDIDLVMSFFSPDVSYSDFAFEAVNMDFTSTRDYMDKMFHAVDDLHLTQVSLTGDKDFTASEWVMTYKLKSSDKVGEVVKMRGVSLSWYDAQGLIVRNNDYSLKWSGDID
What is the function of this protein?
Cyclase; part of the gene cluster that mediates the biosynthesis of aurovertins, fungal polyketides that exhibit potent inhibition of adenosine triphosphate synthase (PubMed:26340065).  Tha biosynthesis starts with the HR-PKS aurA that selects propionate as the starter unit; synthesizes a hexa-ene chain through the repeated functions of the KR and DH domains in the first six iterations; selectively introduces three alpha-methyl substitutions at C4, C6, and C16 using the S-adensylmethionine-dependent cMET; and shuts off KR and DH in the last three iterations to afford a 1,3,5-triketo portion that can undergo intramolecular cyclization to yield the alpha-pyrone intermediate (PubMed:26340065).  AurE may act as a cyclase and enhances the rate of pyrone formation and product release of aurA (PubMed:26340065).  The methyltransferase aurB then methylates the C17 hydroxyl group (PubMed:26340065).  C17 methylation is required to initiate epoxidation by the downstream monooxygenase aurC (PubMed:26340065).  The monooxygenase aurC and the epoxide hydrolase aurD can iteratively transform the terminal triene portion of the methylated precursor into the dioxabicyclo[3. 2. 1]octane scaffold of aurovertin E.  Epoxidation modifications of the precursor occur in two separate steps; bis-epoxidation of the two terminal olefins takes place first, followed by another epoxidation that occurs at C7-C8 after tetrahydrofuran formation (PubMed:26340065).  The O-acyltransferase aurG converts aurovertin E to aurovertin A (PubMed:26340065).
What are the official names of this protein?
Cyclase aurE, Aurovertin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the aurE cyclase family.
Protein: RS15_MYCAP
Sequence: MITKEQKAQIVAKYGANKKDTGNIFVQIAILTAEIEDLKPHFLANPKDNHSRRGFIAKITKRRILLQHLKKENFELYNKVLAELNLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: FMT_BAUCH
Sequence: MRILFAGTPSFAAHYLSVLINSPYKVVGVLTQPDRAAGRGNYLATSAVKQLAIKHNLPVFQPEYLHENNGKHIIEHISVDILVVVAYGMIIPQDMLMFPKLGGINIHGSLLPRWRGAAPIQRALWAGDIKTGITIIQMDDGLDTGPILYQVACKILPVDTSTTLYAKLAKIGSTALLATLKQIITGSQVIEPQNNKFATYARKLNKKEARIDWQLTANQLERCIRAFNPWPISFFKIRDTIIKVWGAQIDDINYHHIPGTILSVDPVGIKIATGKGAIIITQIQLAGTKQMPVKDFLNSRPTWFIPGNILE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: APAG_SHEON
Sequence: MSALDNSIRVEVKTEYIEQQSSPEDEKYLFSYTITIINLGEQAAKLETRHWIITDANGKTSEVQGAGVVGETPTIPPNTAYQYTSGTVLDTPFGIMYGTYGMVSESGEHFNAIIKPFRLATPGLLH
What are the official names of this protein?
Protein ApaG.
Protein: WEX_ARATH
Sequence: MSSSNWIDDAFTEEELLAIDAIEASYNFSRSSSSSSSAAPTVQATTSVHGHEEDPNQIPNNIRRQLPRSITSSTSYKRFPLSRCRARNFPAMRFGGRILYSKTATEVDKRAMQLIKVLDTKRDESGIAFVGLDIEWRPSFRKGVLPGKVATVQICVDSNYCDVMHIFHSGIPQSLQHLIEDSTLVKVGIGIDGDSVKLFHDYGVSIKDVEDLSDLANQKIGGDKKWGLASLTETLVCKELLKPNRIRLGNWEFYPLSKQQLQYAATDAYASWHLYKVLKDLPDAVSGS
What is the function of this protein?
Exonuclease that digests recessed strands of DNA duplexes in the 3' to 5' direction but hardly single-stranded DNA or blunt-ended duplexes.  Also able to digest 3'-protruding strands and 3'-recessed strand termini of duplexes containing mismatched bases.
What are the official names of this protein?
3'-5' exonuclease, Werner Syndrome-like exonuclease.
What are the subcellular locations of this protein?
Nucleus.
Protein: STHA_MYCTO
Sequence: MREYDIVVIGSGPGGQKAAIASAKLGKSVAIVERGRMLGGVCVNTGTIPSKTLREAVLYLTGMNQRELYGASYRVKDRITPADLLARTQHVIGKEVDVVRNQLMRNRVDLIVGHGRFIDPHTILVEDQARREKTTVTGDYIIIATGTRPARPSGVEFDEERVLDSDGILDLKSLPSSMVVVGAGVIGIEYASMFAALGTKVTVVEKRDNMLDFCDPEVVEALKFHLRDLAVTFRFGEEVTAVDVGSAGTVTTLASGKQIPAETVMYSAGRQGQTDHLDLHNAGLEVQGRGRIFVDDRFQTKVDHIYAVGDVIGFPALAATSMEQGRLAAYHAFGEPTDGITELQPIGIYSIPEVSYVGATEVELTKSSIPYEVGVARYRELARGQIAGDSYGMLKLLVSTEDLKLLGVHIFGTSATEMVHIGQAVMGCGGSVEYLVDAVFNYPTFSEAYKNAALDVMNKMRALNQFRR
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Probable soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_METTP
Sequence: MPKSHGFRKNTRDKLKKSVRERGISPVVRAIQDFAVGEKVHIIIDPSIHKGMPHPKFHGRTGTVVGRRGRAYVLEVPDQSAKKLVIALPEHLVAQK
What are the official names of this protein?
50S ribosomal protein L21e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
Protein: GP158_RAT
Sequence: MGAMAYSLLLCLLLAHLGLGEVGASLDPSERPDSSRERTSRGKQHGQQLPRASAPDPSIPWSRSTDGTILAQKLAEEVPMDVASYLYTGDFHQLKRANCSGRYELAGLPGKSPSLASSHPSLHGALDTLTHATNFLNMMLQSNKSREQTVQDDLQWYQALVRSLLEGEPSISRAAITFSTESLSTPAPQVFLQATREESRILLQDLSSSAHHLANATLETEWFHGLRRKWRPHLHRRGSNQGPRGLGHSWRRRDGLGGDRSHVKWSPPFLECENGSYKPGWLVTLSAAFYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYQCVCKAGFYHPRVFSVNNFQRRGPDHHFSGSTKDVSEEAHVCLPCREGCPFCADDRPCFVQEDKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWVRLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVIVLVVFWFLVGWTSSMCQNLERDILLVGQGQTSDNLTFNMCLIDRWDYMTAVAEFLFLLWGIYLCYAVRTVPSAFHEPRYMAVAVHNELIITAIFHTIRFVLASRLQPDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGTDHSAAKGTGLVRKNPTESSGNTGRPKEESLKNRVFSLKKSHSTYDHVRDQTDESSSLPTESQEEEVTENSTLESLSSKKLTQKVKEDSEAESTESVPLVCKSASAHNLSSEKKPGHPRTSMLQKSLSVIASAKEKTLGLAGKTQTLVMEDRAKSQKPQPKDRETNRKYSNSDNTETNPNSNHTEELRKPQKSGIMKQQRVNLPTANPDASSSTTQIKDNFDIGEVCPWEVYDLTPGPVPSEPKAQKHVSIAASEVEQNPASFSKEKSHHKPKAAEGLYQANHKSIDKTEVCPWESHGQSPLEDENRLISKTPVLPGRAREENGSQLYTTNMCAGQYEELPPKAVASKVENENLNQMGDQEKQTSSSVDIIPGSCISSNNSPQPLTSRAEVCPWEFEPLEQPNAERIVALPASSALSASKIPGPRK
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 158.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAD_COXBN
Sequence: MKPIAIYPGTFDPLTNGHVDIIERALPLFNKIIVACAPTSRKDPHLKLEERVNLIADVLTDERVEVLPLTGLLVDFAKTHQANFILRGLRAVSDFDYEFQLAHMNYQLSPEIETIFLPAREGYSYVSGTMVREIVTLGGDVSPFVPPLVARHLQKRREK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLH12_BOVIN
Sequence: MRGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVISWVKHAKKEREGSLPDLLQYVRMPLLTPRYITDVIDTEPFIRCSLQCRDLVDEAKKFHLRPELRTQMQGPRTRAHIRANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWANVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSSLSSIECYDPIIDSYGLVTSMGTQRCDAGVCALREK
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.  The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B).  The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export.  As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3.  The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.
What are the official names of this protein?
Kelch-like protein 12.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle.
Protein: RHMD_SALDC
Sequence: MTLPKIKHVRAWFIGGATAEKGAGGGDYHDQGGNHWIDDHIATPMSKYRDYEQSRQSFGINVLGTLIVEVEAENGQTGFAVSTAGEMGCFIVEKHLNRFIEGKCVSDIKLIHDQMLGATMYYSGSGGLVMNTISCVDLALWDLFGKVVGLPVYKLLGGAVRDEIQFYATGARPDLAKEMGFIGGKMPTHWGPHDGDAGIRKDAAMVADMREKCGPDFWLMLDCWMSQDVNYATKLAHACAPFNLKWIEECLPPQQYEGYRELKRNAPAGMMVTSGEHHGTLQSFRTLAETGIDIMQPDVGWCGGLTTLVEIAALAKSRGQLVVPHGSSVYSHHAVITFTNTPFSEFLMTSPDCSTLRPQFDPILLDEPVPVNGRIHKSVLDKPGFGVELNRDCHLKRPYSH
What is the function of this protein?
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
What are the official names of this protein?
L-rhamnonate dehydratase, RhamD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
Protein: RSMG_LACLS
Sequence: MTPDEFLSALTEFDIQLSDKQIKQFERYFELLVEWNEKINLTAITEKNEVYLKHFYDSVAPILYGLITDQPVSILDIGAGAGFPSLPMKIIFPELEVTIIDSLNKRINFLSLLTEELGLENVTLLHGRAEDFGQDSNYRATFDFVTARAVARLSVLSEFTISFLKKNGNLLSLKAAQFEEELTDAKKAIAILGGKFIKEIAYELPNGDERHIAVIEKKKETPKKYPRKAGTPAKSPIK
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX15_GRARO
Sequence: MKTSVVFVIAGLALLSVACYASELKEQSSINEVLSTIFHFEQPEERDCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVFGK
What is the function of this protein?
Potent voltage-gated sodium channel blocker (By similarity).  Potently inhibits the voltage-gated sodium channels Nav1. 7/SCN9A (IC(50)=0. 58-10 nM) (By similarity).  Shows a moderate activity on Nav1. 1/SCN1A (IC(50)=6 nM), Nav1. 2/SCN2A (IC(50)=5-128 nM), Nav1. 3/SCN3A (IC(50)=20. 3-170 nM), and Nav1. 6/SCN8A (IC(50)=17-20. 1 nM) (PubMed:29703751) (By similarity).  Shows an unclear inhibition of Nav1. 4/SCN4A (IC(50)=200 nM to >10 uM), Nav1. 5/SCN5A (IC(50)=140 nM to >10 uM) and Nav1. 8/SCN10A (IC(50)=68-12200 nM) (PubMed:29703751) (By similarity).  Weakly blocks the low voltage-gated calcium channels Cav3. 1/CACNA1G (30% inhibition of the peak current by 9. 8 nM of the toxin) (PubMed:21740921).  It shows moderate affinity for lipid bilayers (PubMed:29703751).
What are the official names of this protein?
Toxin GTx1-15, Beta/omega-theraphotoxin-Gr2a, Beta/omega-TRTX-Gr2a, GpTx-1, GpTx-I.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 08 (Gtx1-15) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FBK37_ARATH
Sequence: MAIISETSDDGSHGGVPNKKPEELHKNPKEDDHQEEEVENHPPIPRQIPQALIRRTVALIKRCHYPSLSLLSKAFRIVISSPELHQTRSSLNLTEPVLYALIGFPPHSFPNWFILNHNITRNIPLRLSAIGSLPPMNPGSAVVTIGYKMYVIGGLIGPNNPVKTVFVIDCRVHTCNYLPTMHRARYRAVAEVINGKIYVIGGCEKRYDDWIEVFDVVTGIWSTVPDRSHFMSSLPGGGFVTSVVMQNKIYILDATCGLVYDPIDGTWESGELGTTLKSYWYKPCCVIEDLLYSFDPYCLQGSPINVYDPNVMVWTPMMGTGIRAFPDLDYFECKMANFGGKLMVFGATYNNPVTDTWCIEMALIKGETGPILGMIDSMVPVLRSVYSPYIDLCRSVTF
What are the official names of this protein?
Putative F-box/kelch-repeat protein At2g29780.
Protein: MTK_ARATH
Sequence: MSFEEFTPLNEKSLVDYIKSTPALSSKIGADKSDDDLVIKEVGDGNLNFVFIVVGSSGSLVIKQALPYIRCIGESWPMTKERAYFEATTLRKHGNLSPDHVPEVYHFDRTMALIGMRYLEPPHIILRKGLIAGIEYPFLADHMSDYMAKTLFFTSLLYHDTTEHRRAVTEFCGNVELCRLTEQVVFSDPYRVSTFNRWTSPYLDDDAKAVREDSALKLEIAELKSMFCERAQALIHGDLHTGSVMVTQDSTQVIDPEFSFYGPMGFDIGAYLGNLILAFFAQDGHATQENDRKEYKQWILRTIEQTWNLFNKRFIALWDQNKDGPGEAYLADIYNNTEVLKFVQENYMRNLLHDSLGFGAAKMIRRIVGVAHVEDFESIEEDKRRAICERSALEFAKMLLKERRKFKSIGEVVSAIQQQS
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate in the methionine cycle.  Contributes to the maintenance of AdoMet homeostasis and is required to sustain high rates of ethylene synthesis.
What are the official names of this protein?
Methylthioribose kinase, AtMTK, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: RS17_BACC0
Sequence: MSERNQRKVYTGRVVSDKMDKTITVLVETYKTHSLYGKRVKYSKKYKAHDEQNQAKLGDIVKIMETRPLSATKRFRLVEIVEEAVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RPOA_VIBVY
Sequence: MQGSVTEFLKPRLVDIEQISSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIEGVLHEYSTKEGVQEDILEILLNLKGLAVRVAEGKDEVFITLNKSGSGPVVAGDITHDGDVEIANPEHVICHLTDDNAEIAMRIKVERGRGYVPASARIHTEEDERPIGRLLVDATYSPVDKIAYAVEAARVEQRTDLDKLVIDMETNGTLEPEEAIRRAATILAEQLDAFVDLRDVRVPEEKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIAED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: CSPH_ECOL6
Sequence: MSRKMTGIVKTFDRKSGKGFIIPSDGRKEVQVHISAFTPRDAEVLIPGLRVEFCRVNGLRGPTAANVYLS
What are the official names of this protein?
Cold shock-like protein CspH, CSP-H.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_ALIF1
Sequence: MSQGYLNFPHIDPVLIEIGPLAVRWYGLMYLFGFMFALWLANKRADKPNSGWTRDQVSDLLFAGFLGVVIGGRVGYVLFYNFGYFLDNPLYLFEVWTGGMSFHGGLLGVISAMLWYGYKNNRSFFTIADFVAPLVPFGLGAGRLGNFMNGELWGRVTDVPWAMVFPTGGPFPRHPSQLYEFALEGVVLFLILNWFIRKPRPLGTVSGLFLFGYGTFRFLVEYVRQPDAQLGLFGDWISMGQILSLPMVIGGLLMMLWAFKRNLYPSIEQPQSTTKKK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.