PharMolix/UniProtQA huggingface dataset:
Protein: PYRE_BACCL
Sequence: MKHDIAAKLLQIGAVALQPNEPFTWSSGLKSPIYCDNRLTLAYPGVRRLIADALAELIRTHFPKADLIAGTAAGIPHAAWVSERLELPMCYVRSQAKRHGKGKQIEGQARPGQRVVVIEDLISTGGTSLAAVRALKEAGCEVLGVAAIFTYGLEKAKQAFAAENLPAYTLTDYNTLIETAVRLGAVSEHDLATLRQWRENPEEWGS
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: NUDL_SALHS
Sequence: MDTSRLTLDHFLSRFQLLRPQITHETLNQRQAAVLIPVVRRPQPGLLLTQRAIHLRKHAGQVAFPGGAVDSTDASLIAAALREAQEEVAIPPQAVEVIGVLPPVDSVTGFQVTPVVGIIPPNLPWRASEDEVSAVFEMPLAQALQLGRYHPLDVYRRGNSHRVWLSWYEHYFVWGMTANILRELALQIGVKP
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: ASTB_SALPA
Sequence: MTAHEVNFDGLVGLTHHYAGLSFGNEASTRHRFQVSNPRLAVKQGLLKMKALADAGFPQAVIPPHERPFIPALRQLGFTGSDEQILDKVARQAPRWLSSVSSASPMWVANAATVCPSADALDGKVHLTVANLNNKFHRALEAPVTEALLRAIFRDESQFSVHSALPQVALLGDEGAANHNRLGGEYGSAGVQLFVYGREEENEIRPARYPARQSREASEAVARLNQVNPQQVIFAQQNPEVIDQGVFHNDVIAVSNRQVLFCHEAAFARQKVLINQLRTRVDGFMAIEVPAGEVSVSDAVAPYLFNSQLLSRDDGSMLLVLPRECQDHAGVWRYLNKLVAEDNPISAMQVFDLRESMANGGGPACLRLRVVLTEEERRAVNPAVMMNDALFTALNAWADRYYRDRLTAADLADPLLLREGREALDVLTRLLDLGSVYPFQQTGAADG
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: LIPB_XYLFT
Sequence: MDAVNACGAVAPWHVGRAALLRMLGAQPYVPVWHAMQRFTDVRDATAVDELWVVEHEPVFTLGQAGKLEHVLAPGEIPVVHVDRGGQVTYHGPGQLVVYPLLDLSRLGLGVRDYVYGIEQAVINTLAQWNILGERREHAPGVYVGDAKIAALGIRVRRGCSFHGVAFNVAMDLEPFHRIHPCGYRGLQVTSVLDLGGPSEMDTVAAALLAELARQFGFVLHPTSGWLSS
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CX6C1_THUOB
Sequence: MSLAKPAMRGLLGKRLRFHLPIAFTLSLVAALGFKYGVTEPRKQAYADFYKQYDAVKDFNAMREAGIFESVRPSGE
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 6C-1, Cytochrome c oxidase polypeptide VIc-1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6c family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ACOR_CUPNH
Sequence: MDLRQREHIETVVQATTYLAPPAVLADRIAHDAIIQNSWRRCVHQYGLDPSRMQEARILPQPRLREHQERIDDFARIARHGLQSLYGQVAGLGYVVLLTDAQGVTVDYIGEARSDAALRHAGLYLGAEWSESGAGTCAVGTALATGQALTVHQADHFDATHIPLTCTAAPLFDTHGNLHAILDISALTSPQAKDSQGLALQMVRIYAAHIENANFLRAHRRDWILKLNVAPEFVDVNPEYLLALDEAGRIVGHNHRARLMLEGELGGAPGATVLGQRFETLFDARLEDLGHYVYSRPSEQRLVALTRSGGLLYLSVLPPALRWQAPPAETQVAMPDALAALTGGDAALQLQLQRAARLVDSPINLLIHGETGSGKEFLAKALHLASARRGGPFVAVNCAAIPETLIESELFGHLPNSFSGAGPRGKRGLIQEADGGTLFLDEIGDMPRELQSRLLRVLAEGEVLPVGAARPVPVRLRVISATHHSLEQLVADGRFREDLYYRLNGARFTLPPLRARTDLDWLVRKLLQEGSAEGSEITLSPAARERLHRHRWPGNLRELRNVLEYARAVCADGYIDVPDLPDSLAGPAPSAALPQPGPAQSPAAAPFDPHQLPPEGMLLMQYLRASGWNLSAVARQIGVSRMTLYRRMERYGIQSPNRRDGGPEPTDA
What is the function of this protein?
Required for sigma-54-dependent transcription of acoXABC.
What are the official names of this protein?
Acetoin catabolism regulatory protein.
Protein: GATB_BARQU
Sequence: MGIIDTRIPDSKRFISGVTGDWEVIIGMEVHAQIISNSKLFSGASTKFGAEPNNHVSLIDAAMPGMLPVINQECVRQAVRTGLGLKAHINLKSVFDRKNYFYPDLPQGYQISQFRYPVVGEGKITISIGPDPNGQFEDIEIGIERLHLEQDAGKSIHDQHPTMSFVDLNRSGVALMEIVSKPDMRSSDEAKAYMTKLRTIVRYLGTCDGNMDEGSMRADVNVSVRRPGENFGTRCEIKNVNSIRFIGQAIEYEARRQIAILEDGGVIDQETRLFDAAKGETRSMRSKEEAHDYRYFPDPDLLPLEFDQAFVDALAVELPELPDDIKARFINKMGLTPYDASILVAERAIADYFEEVACGRDGKMAANWVINDLLGALNKDNCAIEETPVAPSQLGAIIDLIKEGTISGKIAKDLFEIIWNEGGDPRQVVEERNMKQVTDIKAIERAVDEIVSNNSDKVAQAKQKPTLIGWFVGQVMKATGGKANPQTVNELVKVKLGID
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: DNAJ_MYCCT
Sequence: MKKKDYYEVLGVSKTASEQEIRQAYRKLAKQYHPDLNKSPDAHDKMVEINEAADVLLDKDKRKQYDQFGHRAFDNSSGFSSNFTDFEDLFSNMGSSGFSSFTNIFSDFFGSNKSDYQRSTKGQSVSIDIYLTFKELLFGVDKIIELDLLTNCSACFGSGAESNSDINICNNCHGTGEVLVQKNMGFFQFQQSAKCNVCNGAGKIIKNKCKNCKGKGKYLERKKIEVNIPKGIRPNQQIKLSQKGHASTNNGVNGDLIIDIYLKESKVFEIINNNDILMTYNISYLDSILGNEIIIKTLDGDIKYKLPKSINSNEAIIINNKGLYKSINKDKRGDLIIKVNIVVPKNLTKKEKELIEQIYEQTSFNPENNINQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTH_HALSA
Sequence: MTTEGVVIDGESLTPAAVDAVARHDAPVSIAAGAREAVRESRARIADVLGGDEAVYGVNTGFGSMSDTRIDAADREALQANLVRSHAAGAGSELDTAAVRALLVTRLNALAKGYSGIRERVLDVLVGLLNEGVHPVVPSRGSLGASGDLAPLAHMSRVLIGEGQADVAGERMPAAEALAAADLEPVTLQAKEGLALINGTQLTTGVAALALVDAERVLRSADTAGALTTEVTMSTTASCAPAIHEVRPHDGQAVSARHIRNLTAGSEVLDHHRDCDRVQDAYSIRCLPQVHGAVRDALDHLRAAVATELNSATDNPLVFAGDRVGPRASGTDRAAVVSGGNFHGEVLALRLGYAASALAELAAISERRTDRLLNPETQEPHLEPFLAPDSGLHSGLMIPQYTAASLVNDLRSLGQPTLDNASVSGAQEDHVSMSAGAAYNFREAVEKAATVVGVELLCGAQGREFLDPDLALGAGTAAAYDLVREVSEPVAGDRALADDMAAVGDLVRAGLVEDAVARALDAPLA
What are the official names of this protein?
Probable histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_CLOB6
Sequence: MNIRPLGDRVVIKRVEAEETTKSGIVLPGAAKEKPQVAEVIAVGPGGLVDGKEVKMELKVGDKVLFSKYAGNEVKIEGEEVTILKQDDILAVVEG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPNP_CUPPJ
Sequence: MEVSQFDNVSVVKKANLYFDGKCVSHTVLFSDGTRKTLGVIFPATLTFNTGAPEIMEINAGVCRVRLAGSEAWQTYGAGQQFDVPGNSSFDIEVQETLDYVCHFG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: FEOC_YERP3
Sequence: MASLLQLRDAIALNGSAEASQLSRQLAIPLPLVNAMLEKLTAMGKIERIELDHSGCLTGSCKSCPEGHQHCNTVIYQLKEPHAHQ
What is the function of this protein?
May function as a transcriptional regulator that controls feoABC expression.
What are the official names of this protein?
Probable [Fe-S]-dependent transcriptional repressor.
What is the protein family that this protein belongs to?
Belongs to the FeoC family.
Protein: RPOB_DRANE
Sequence: MLGDGKEGTSTIPGFNQIQFEGFYRFIDQGLIEELSKFPKIEDIDHEIEFQLFVETYQLVEPLIKERDAVYESLTYSSEIYVSAGLIWKTSRNMQEQRIFIGNIPLMNSLGISIVNGIYRIVINQILQSPGIYYQSELDHNGISVYTGTIISDWGGRLELEIDKKARIWARVSRKQKISILVLSSAMGSNLREILENVCYPEIFLSFLTDKEKKKIGSKENAILEFYQQFSCVGGDPIFSESLCKELQKKFFHQRCELGRIGRRNINSRLNLNIPQNNIFLLPRDILAAADHLIGMKFGMGTLDDMNHLKNKRIRSVADLLQDQLGLALARLENVVKGTIGGAIRHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTANFRIRDIHPSHYGRICPIDTSEGINVGLIGSLSIHARIGDWGSLESPFYELFCKSKKARIRMLFLSPSQDEYYMIAAGNSLALNRDIQEEQAVPARYRQEFLTIAWEEVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVPAIAEHEGKILSTDTEKIILSGNGNTLSIPLIMYQRSNKNTCMHQKPQVRRGQCIKKGQILADGAATVGGELALGKNILVAYMPWEGYNFEDAVLISECLVYGDIYTSFHIRKYEIQTHVTTQGPERITKEIPHLEGRLLRNLDKNGIVMLGSWVETGDILVGKLTPQMAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWVQKKGGSSYNPEIIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFECSLGLAGSLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRIFDGRTGDPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPKPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRQEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DEOB1_STRA1
Sequence: MSQFDRIHLVVLDSVGIGAAPDANDFVNAGVPDGASDTLGHISKTVGLAVPNMAKIGLGNIPRPQALKTVPAEESPSGYATKLQEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEDIITKIEDFSGRKVIREANKPYSGTAVIDDFGPRQMETGELIIYTSADPVLQIAAHEDIIPLEELYRICEYARSITMERPALLGRIIARPYVGEPGNFTRTANRHDYAVSPFEDTVLNKLDQAGIDTYAVGKINDIFNGSGINHDMGHNKSNSHGIDTLIKTMGLSEFEKGFSFTNLVDFDALYGHRRDSHGYRDCLHEFDERLPEIISAMRDKDLLLITADHGNDPTYAGTDHTREYIPLLAYSPSFTGNGLIPVGHFADISATVADNFGVDTAMIGESFLQDLV
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase 1, Phosphodeoxyribomutase 1.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHG26_MOUSE
Sequence: MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFAAVLRNLEDERSRMIENASEVLITPLEKFRKEQIGAAREAKKKYDKETEKYCGTLEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNRDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETETDICAEWEIKTVTSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDVPLTNAQLHLSRKKSSDSKPPSCSKRPLTLFHAVPSTEKQEQRNSIINSSLESVSSSANSILNSSSSLQPNLNSSDSNLDVVKPSRPSSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPIRSVAGFVWFSVAAVVLSLAWSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVREDSSTPFRKAKALYACQAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL
What is the function of this protein?
GTPase-activating protein for RHOA and CDC42.
What are the official names of this protein?
Rho GTPase-activating protein 26, Rho-type GTPase-activating protein 26.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers and cortical actin structures.
Protein: NO551_SOYBN
Sequence: KYDERTESVHEVNETDYEQCNTVGKEHVLFNDGNTKVMLTKSGFRHFISGNQSHCQMGLKLMVVVMSNNTKKKLIHSPSPSSPSPSPSPSPSPSPSPSPSLSSPSPSPLPNNQGVTRSSGAEFIGVMMWLGVMMLLL
What is the function of this protein?
May act as a carbohydrate transporter.
What are the official names of this protein?
Early nodulin-55-1, N-55-1.
What is the protein family that this protein belongs to?
Belongs to the early nodulin-like (ENODL) family.
What are the subcellular locations of this protein?
Symbiosome, peribacteroid membrane.
Protein: AURAA_XENLA
Sequence: MERAVKENHKPSNVKIFHPMTEGAKRIPVNQPQSTQFRPPGTAVSAQRILGPSNVPQRVLAQAQKPILSSQKPTTQIPLRPATQGHQSSKPQGPNENRNPQQTSHSSTPNVEKKGSTDQGKTSAVPKEEGKKKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIKQLAEALLYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDETVDLWSLGVLCYEFLVGKPPFETDTHQETYRRISKVEFQYPPYVSEEARDLVSKLLKHNPNHRLPLKGVLEHPWIIKNSQLKKKDEPLPGAQ
What is the function of this protein?
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression.  Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis.  Phosphorylates numerous target proteins.  Important for microtubule formation and/or stabilization.
What are the official names of this protein?
Aurora kinase A-A, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Serine/threonine-protein kinase 6-A, Serine/threonine-protein kinase Eg2-A, pEg2, Serine/threonine-protein kinase aurora-A, p46Eg265.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the spindle pole during mitosis especially from prophase through anaphase. Partially colocalized with gamma tubulin in the centrosome, from S to M phase.
Protein: Y2004_MYCTO
Sequence: MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI
What are the official names of this protein?
Uncharacterized protein MT2060.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: NQO1_PONAB
Sequence: MVGRRALIVLAHSERTSFNYAMKEAAVAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPENFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFVGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
What is the function of this protein?
Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors.  In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity).  Regulates cellular redox state primarily through quinone detoxification.  Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms.  In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity).  Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity).  Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions.  Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity).
What are the official names of this protein?
NAD(P)H dehydrogenase [quinone] 1, Azoreductase, DT-diaphorase, DTD, Menadione reductase, NAD(P)H:quinone oxidoreductase 1, Phylloquinone reductase, Quinone reductase 1, QR1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: OUSX_DICD3
Sequence: MRNISMATLALTTVLSTGLFAADDLPGKGITVKPVQSTISEETFQTLLVSKALEKLGYTVDKPSEVDYNVGYTSIANGDATFTAVNWQPLHDDMYQAAGGDAKFYRQGVYVSGAAQGYLIDKKTAERYHITRLDQLKDPKLAKLFDTNGDGKADLTGCNPGWGCDSVINHQIQAYGLGDTVNHNQGNYAALIADTIARYKQGKSVIFFTWTPYWVSDVLVPGRDVVWLQVPFSSLPGKQKGTDTKLPNGANYGFPVNNMRIVANKDWAEKNPAAAKLFAIMKLPLADINAQNLRMHQGEASQQDIERHVNGWINAHQAQFDGWLNAARAAAK
What is the function of this protein?
Part of the OusB ABC transporter complex involved in glycine betaine and choline uptake.  Binds glycine betaine.
What are the official names of this protein?
Glycine betaine-binding periplasmic protein OusX.
What are the subcellular locations of this protein?
Periplasm.
Protein: CH10_SULDN
Sequence: MNFQPLGKRVLVKRVEEANTTASGIIIPDNAQEKPSRGEVVAVSSEVKEMLCGDKVLFGKFSGSEVTLDGEKFLIIDSEDIFGIIK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_DICT6
Sequence: MTKLYIFDTTLRDGEQTPGVNLNKEEKLEIAKQLAKLNVDIIEAGFPIASPGEFEAVKTIAENVKGPVIAALARAIPMDIDRAWEAIKYSESPRIHTFIATSDIHIEKKLKKTRDEVLEQAVSAVKYAKRYCSDVEFSAEDAVRSDFNFLVKIFEAVIDAGATVINIPDTVGYALPWEFGDLIRRLKENIKNIDKAIVSVHCHNDLGLATANSLSAIVNGAEQVECTINGLGERAGNAAMEEIVMAIKVRRLPFEVGIKTEEIYKTSKLVSNLTGIVIQPNKAIVGENAFAHESGIHQHGVIQDPSTYEIIDPKMIGIPESKIVLGKHSGKHAFEKRLQELGYSLPPEQLEEAFKKFKELADKKKEITDKDIEALVSNQIKLVPEYYRLVHLQVVSGIGIVPTATIIISEDGEEIKTVEIGNGPVDAVYKAIAKAIKIPHSLEDFSLKSVTGGTDALGEAMVKLSDKDGNIYVGRATSTDIVEASALAYLRALNQLVMLKGKG
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: FAM3A_MOUSE
Sequence: MRLAGPLRIVALIIIMGLTWILVTILLGGPGVGLPRIQQFFTSPENSVTAEPRARKYKCGLPQPCPEEHLSFRIVSGAANVIGPKICLEDKMLMSSVKDNVGRGLNIALVNGVSGELLEARAFDMWAGDVNDLLKFIRPLHEGTLVFVASYDDPATKMNEETRKLFSELGSRNAKDLAFRDSWVFVGAKGVQNKSPFEQHMKNSKHTNKYEGWPEALEMEGCIPRRSIAG
What are the official names of this protein?
Protein FAM3A.
What is the protein family that this protein belongs to?
Belongs to the FAM3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL6_CHESB
Sequence: MSRIGKKPVPVPQGVTANVDGQVVTAKGPKGELKFVVNDDVLVKLEDGAIAVDPRNESKMARSKWGMSRTQIANILTGVKDGFEKRLEINGVGYRAAMQGKNLQLSLGFSHDVSYEPPTGITITVPKPTEIVVSGIDKQVVGQVAAEIRKYRGPEPYKGKGVKYAGETIVRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NADD_SHEWM
Sequence: MRIGILGGTFDPIHFGHIRPAQEVKQTLNLDKVWLMPNHIPPHKTSTSVSTEQRLEMTQLVCDEYSEFELCAIEAKREAPSYLVTTLKQITNSHPNDEFFFIMGMDSLLSLDTWFEWQSLFGLCHIVVCQRPGWSLSPDSSIFSQYQSRVRSPNKITGKQSGLIIPIPVTPQAISSTHIREQLSEGITPTNALPDKIIQYIEDKNLYRT
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: BCP_ECO57
Sequence: MNPLKAGDIAPKFSLPDQDGEQVNLTDFQGQRVLVYFYPKAMTPGCTVQACGLRDNMDELKKAGVDVLGISTDKPEKLSRFAEKELLNFTLLSDEDHQVCEQFGVWGEKSFMGKTYDGIHRISFLIDADGKIEHVFDDFKTSNHHDVVLNWLKEHA
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
What are the official names of this protein?
Putative peroxiredoxin bcp, Bacterioferritin comigratory protein, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin Bcp.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.