PharMolix/UniProtQA huggingface dataset:
Protein: NALP4_HUMAN
Sequence: MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITRVEI
What is the function of this protein?
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.  Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation.  Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
Protein: SCONB_ARTOC
Sequence: MATDTPPQLAGPPTPAMETLDRDVVMSPRKRRRLSASAEPELTEPESDGTSGGRGAAAEAPETAALEPKSLFNSTSTESSITSSSTTTTTTSSSSSIAPFLAKHIRDQHASRNRFAPADSSLPRRKADSKYCYRHRPDLKCRRQADEPTVDQMQRDLSTLSQNDQQSIAHFWSLFSAAPSKHRNLMLQGIVAQCCFPQLSFLSASVRDLIRIDFVTALPPEISFKILSYLDTASLCNAAQVSRNWRHLADDDVVWHRMCEQHIDRKCEKCGWGLPMLDRKRLKDTKRQVQLRAAGKEAVTGRQQQQHRPWKAVYMDRFKVGTNWKYGRCTTTIFRGHTNGVMCLQFDDNILATGSYDATIKIWDIETGKEIRTLRGHESTIRCLQFDDTKLISGSLDRTIKVWSWRSGECISTYTGHQGGVLCLHFDSTTLASGSKDNTIKIWNFQDKSTQILRGHTDWVNAVKLDTASRTVFSASDDLTVRIWDLDTGKCIHTYAGHVGQVQQVLPLPREFEFKHTSHCDDDRSDRLSGSESPDHRASHDSNHAPDLPTTSAPPTQPMSPLFEALFNEDRPAPPRYMLTAALDSTLRLWEVHTGRCLRTFFGHIEGVWGLAADTLRLVSGAQDHMTKVWDPRTGTCERTFTGHRGPVTCVSLSDSRMATGSEDCEVRMYSFKA
What is the function of this protein?
Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
What are the official names of this protein?
Probable E3 ubiquitin ligase complex SCF subunit sconB, Sulfur controller B, Sulfur metabolite repression control protein B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MET30/SCONB/SCON-2 family.
Protein: RL30_DELAS
Sequence: MTTQQTVKVQLVRSPIGTKESHRATVRGLGLRKLNSISELQDTPAVRGMINKISYLVKVL
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: YR789_MIMIV
Sequence: MDSDNSSNLIDQEIYSVYNEYEGIDIHYGLELSCIKGHIDVFKHCISRGALVSGYERMLYSDWINSPDYVDLLSLAAYNGHFDIVKHLIKSGFDPKYNDYSALNCACERNYLEIVKYLVNYEAVRYLMSAGLKFRLNVTNIPITKISELLAVEQDFIATNSSIDSVKNLLYTSTKNYFSNVIDASLVYAARGGSMDILMYLLELGASHNFAIICASIHGQLDVVKYLLQKGQEYTTKIEYCIIMAAQYGQVNVVKYLIESGNELDHNLDYCLKVTMYYGHTDTVKYLCNRYGERCYTSDCLIMAIEQGHSEIAKFLIVDGGIQLDNDNYIKTAVQRGHINVLKLLVSLGMDFTINKNLPIRIALRECHFQIVEYLIGKGVDIRSNNGYIIRWSLHGNSKNKVSRIIKYVTDNYADMLNVIKF
What are the official names of this protein?
Putative ankyrin repeat protein R789.
Protein: DAPE_STUS1
Sequence: MTAPALSPTLELACELINRPSVTPLDEGCQQLMSQRLAACGFAIEPMHIEDVENFWAIRGNEGPVLCFAGHTDVVPTGPLQAWQNPPFSARIDEQGMLHGRGAADMKGSLAAMVVAVERFTADHPDHKGQIAFLITSDEEGPAHHGTKAVVERLRERGQRLDWCIVGEPSSTSLVGDVVKNGRRGSLGGTLTVRGQQGHVAYPHLAKNPIHLAAPALAELAAEHWDDGNAFFPPTSFQISNLNAGTGATNVIPGTLEAVFNFRFSTESTVEGLQQRTAAILDKHGLDWSIDWALSGLPFLTEPGDLLDGVAKAIRSVTGRETTPSTSGGTSDGRFIATLGTQVVELGPVNATIHQVDEHILASDLDVLTDIYYQTLVNLLAC
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: KGUA_MYCSS
Sequence: MNTGRGVGRVVVLSGPSAVGKSTVVRCLRERIPDLYFSVSATTRAPRPGEVDGVDYSFVTPEAFQQLIDDGALLEWAEIHGGLHRSGTPARPVREATVAGRPVLIEVDLAGARAVKQAMPEALSVFLAPPSWEVLERRLVGRGTETPDVMSRRLDTARTELAAQSDFDVVVVNSQLESACSELVSLLVGHTSAGTNPA
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K2C1B_RAT
Sequence: MSRQFSSQSAFSSRSRRVYSTRSSSGFGGGRQILVSVGQSRRCGGDYGGGFSSRSLYSLGGSKSIFGGLVGRSASGFCQSRGAGGGFGGGFGGGRSFGGGGFGGGYGGGGRFGGGFGGGFGTSNFGLGGFGPSYPPGGIHEVTVNQSLLEPLHLEVDPEIQKIKTQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTRTSSLEPIFEEFINQLQRQVDVLTNEQLRQNSEIRSMQDIVEDYKNKYEDEINKRTNSENDFVVLKKDVDAAFMAKSDLQSRVDTLYGEINFLKYLFDTELSQIQTHVSDTNVILSMDNNRSLDLDSIINAVRTQYELIAQKSKDEAEALYQTKYQELQITAGKHGDDLKNSKMEISELNRNAQRLQAEIANIKKQIEQMHGSISDAEERGERALQDAKQKLQETEEALQQMKEDLARLLRDYQALLGAKLSLDVEIATYRELLEGEESRMSGALQSQVSIWALPSNEGNDLGERLHDPQSQVPVPKLGC
What are the official names of this protein?
Keratin, type II cytoskeletal 1b, Cytokeratin-1B, CK-1B, Keratin-77, K77, Type-II keratin Kb39.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: RSMA_DESHD
Sequence: MENAANYTRRILKGGAKAHKSLGQNFLMDDRVIEAIAAASIKDPEIPVVEIGPGLGVLTRVLAQKAQKVWAVELDRGKVNLLQRELQGLPVDILNMDALKLDLKDIWGTGKGVLVGNLPYYITSPLLMHFLEQKDSLASMVVMVQKEVADRLVAKPGGKDYGILSIAAQVSAQGEKLFEVPPQAFWPAPKVTSAVVRFELRSYPGFRVKEKDFFRVVKAAFSQRRKTLGNSLAGGLGLPKQQIGEILAAAGVDEQRRAETLSIDEFQAVTEAVMKNLD
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_ECO8A
Sequence: MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAQLVTELVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVMTGFRVALAGAQDYYGVEPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGVHETLDELTSRLAEGLLEAAEEAGIPLVVNHVGGMFGIFFTDAESVTCYQDVMACDVERFKRFFHMMLDEGVYLAPSAFEAGFMSVAHSMEDINNTIDAARRVFAKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THNS1_PONAB
Sequence: MLHFNRCHHLKKITQKCFSSIHVKTDKHAQQFLSRTFALAELRKSWYSTHSLVGDKNIILMGPPGAGKTTVGRIIGQKLGCCVIDVDDDILEKTWNMSVSEKLQDVGNEQFLEEEGKAVLNFSASGSVISLTGSNPMHDASMWHLKKNGIIVYLDVPLLDLIHRLKLMKTDRIVGQNSGTSVKDLLKFRRQYYKKWYDARVFCESGASPEEVADKVLNAIKRYQDVDSETFISTRHVWPKDGEQKLSAKFFSEAVIEGLASDGGLFVPAKEFPKLSCGEWKSLVGATYIERAQILLERCIHPADIPAARLGEMIETAYGENFACSKIAPVRHLSGNQFILELFHGPTGSFKDLSLQLMPHIFAHCIPPSCNYVILVATSGDTGSAVLNGFSRLNKNDKQRIAVVAFFPENGVSDFQKAQIIGSQRENGWAVGVESDFDFCQTAIKRIFDDSDFTGFLTVEYGTILSSANSINWGRLLPQVVYHASAYLDLISQGFISFGSPVDVCIPTGNFGNILAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRERKLAQTFSPSIDILKSSNLERHLHLMANKDGQLMTELFNRLESQHHFQIEKALVEKLQQDFIADWCSEGECLAAINSTYNTSGYILDPHTAVAKVVADRVQDKSCPLIISSTAHYSKFAPAIMQALKIKEINETSSSQLYLLGSYNALPPLHEALLERTKQQEKMEYQVCAADVNVLKSHVEKLIQNQFI
What are the official names of this protein?
Threonine synthase-like 1, TSH1.
What is the protein family that this protein belongs to?
Belongs to the threonine synthase family.
Protein: PSB_RHOE4
Sequence: MTVDRAPRITDGDTRLSFGSNLSSFSEYLRVHAPEHLPQNRFADTGGVVMGGGDVAPHGTTIVAISYAGGVLLAGDRRATMGNLIASRDVQKVYVTDDYSAAGIAGTAGIAIELVRLFAVELEHYEKIEGVPLTFDGKANRLSSMVRGNLGAAMQGLAVVPLLVGYDLDAVDPSRAGRIVSYDVVGGRYEERAGYHAVGSGSLFAKSALKKLYSPGIDEDTALRFAVEALYDAADDDSATGGPDLTRGIYPTAVTITSAGAVELSTAKAAEIAREIVAARTATASPEGESAL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PrcB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN600_HUMAN
Sequence: MMKEVLSTGQGNTEVIHTGTLQRYQSYHIGDFCFQEIEKEIHDIEFQCQEDERNGHEAPMTKIKKLTGSTDQHDHRHAGNKPIKDQLGSSFYSHLPELHIIQIKGKIGNQFEKSTSDAPSVSTSQRISPRPQIHISNNYGNNSPNSSLLPQKQEVYMREKSFQCNESGKAFNCSSLLRKHQIPHLGDKQYKCDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAVKSHKCNECGKIFGQNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGEKPYKCEECDKVFSRKSTLESHKRIHTGEKPYKCKVCDTAFTWNSQLARHKRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAWNSHLVRHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVFSCGSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECSKTFRLRSYLASHRRVHSGEKPYKCNECSKTFSQRSYLHCHRRLHSGEKPYKCNECGKTFSHKPSLVHHRRLHTGEKSYKCTVCDKAFVRNSYLARHTRIHTAEKPYKCNECGKAFNQQSQLSLHHRIHAGEKLYKCETCDKVFSRKSHLKRHRRIHPGKKPYKCKVCDKTFGSDSHLKQHTGLHTGEKPYKCNECGKAFSKQSTLIHHQAVHGVGKLD
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 600.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SEC11_ASHGO
Sequence: MNIRQQLTKFLGLFLTLASAFMFWKGLSVVTNSHSPIVVVLSGSMEPAFQRGDILFLWNRERFNKVGDVIVYEVDAKSIPIVHRVVREHRDKNGRQLLLTKGDNNAADDIALYGRKQSYLRRDKDIVGTVKGYLPKLGYVTILVSENQYAKFALMGMLALSSLLGSE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: RL34_LACCB
Sequence: MTTKRTFQPKKRHRERVHGFMKRMSTKNGRKVLARRRAKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: GPD2_CYBJA
Sequence: MTDIGESESDISTDVSALPMLSHSVSYTSIQKPPFVVSVIGSGNWGTTVAKIIAENTRENPLLFEQKVRMWVYEEEFEGSNLSDIINTEHVNKKYLPGIKLPDNLVAVPDLLEAVQYSNILIFNIPHQHLEKILSQLRGNIDPRARAISCLKGLRVNLDGVELLPDIIQDALGIHCGVLAGANLAQEVAEQRFSETTVGYPLPADYKPGDVDHTVLYTLFHRPYFHVHVIEDIAGISCAGALKNIIAISVGFVEGLEWGDNAKAAMLRRGLLEMIKFGRKFFPGCLVSSFTEESAGVADLFTTCTGGRNFKLAKIMAQTGKSAHEVEKEILNGQSAQGLITAKEIHELIKNKGCEEEFPLFETTYQILFHGVRIGILPYMLENKWSISKPNYSS
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Protein: DPP5_TRIRU
Sequence: MAAAKWLIASLAFASSGLAFTPEDFISAPRRGEAIPDPKGELAVFHVSKYNFDKKDRPSGWNLLNLKNGDINVLTTDSDVSEITWLGDGTKVVYINGTDSVKGGVGIWISDAKNFGNAYKAGSVNGAFSGLKLAKSGDKINFVGYGQSTTKGDLYNEAAAKEAVSSARIYDSLFVRHWDTYVGTQFNAVFSGTLTKSGDKYSFDGKLKNLVQPVKYAESPYPPFGGSGDYDLSSDGKTVAFMSKAPELPKANLTTSYIFLVPHDGSRVAEPINKRNGPRTPQGIEGASSSPVFSPDGKRIAYLQMAAKNYESDRRVIHIAEVGTNKPVQRIASNWDRSPEAVKWSSDGRTLYVTAEDHATGKLFTLPADARDNHKPAVVKHDGSVSSFYFIGSSKSVLISGNSLWSNALYQVATPDRPNRKLFYANEHDPELKGLGPNDIEPLWVDGARTKIHSWIVKPTGFDKNKVYPLAFLIHGGPQGSWGDNWSTRWNPRVWADQGYVVVAPNPTGSTGFGQKLTDDITNDWGGAPYKDLVKIWEHVHDHIKYIDTDNGIAAGASFGGFMVNWIQGQDLGRKFKALVSHDGTFVGSSKIGTDELFFIEHDFNGTFFEARQNYDRWDCSKPELVAKWSTPQLVVHNDFDFRLSVAEGVGLFNVLQEKGVPSRFLNFPDETHWVTKPENSLVWHQQVLGWVNKWSGINKSNPKSIKLSDCPIEVVDHEAHSYFDY
What is the function of this protein?
Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini.  Contributes to pathogenicity (By similarity).
What are the official names of this protein?
Dipeptidyl-peptidase 5, Dipeptidyl-peptidase V, DPP V, DppV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9C family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRXR2_RAT
Sequence: MAAIVAALRGSSGRFRPQTRVLTRGTRGAAGAASAAGGQQNFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAQHYGWEVAQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHGTRFLKGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLDPTVTGCUG
What is the function of this protein?
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity).  Maintains mitochondrial thioredoxin in a reduced state.  May play a role in redox-regulated cell signaling.
What are the official names of this protein?
Thioredoxin reductase 2, mitochondrial, Thioredoxin reductase TR3.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TE80_TETTH
Sequence: MEIENNQAQQPKAEKLWWELELEMQENQNDIQVRVKIDDPKQYLVNVTAACLLQEGSYYQDKDERRYIITKALLEVAESDPEFICQLAVYIRNELYIRTTTNYIVAFCVVHKNTQPFIEKYFNKAVLLPNDLLEVCEFAQVLYIFDATEFKNLYLDRILSQDIRKELTFRKCLQRCVRSKFSEFNEYQLGKYCTESQRKKTMFRYLSVTNKQKWDQTKKKRKENLLTKLQAIKESEDKSKRETGDIMNVEDAIKALKPAVMKKIAKRQNAMKKHMKAPKIPNSTLESKYLTFKDLIKFCHISEPKERVYKILGKKYPKTEEEYKAAFGDSASAPFNPELAGKRMKIEISKTWENELSAKGNTAEVWDNLISSNQLPYMAMLRNLSNILKAGVSDTTHSIVINKICEPKAVENSKMFPLQFFSAIEAVNEAVTKGFKAKKRENMNLKGQIEAVKEVVEKTDEEKKDMELEQTEEGEFVKVNEGIGKQYINSIELAIKIAVNKNLDEIKGHTAIFSDVSGSMSTSMSGGAKKYGSVRTCLECALVLGLMVKQRCEKSSFYIFSSPSSQCNKCYLEVDLPGDELRPSMQKLLQEKGKLGGGTDFPYECIDEWTKNKTHVDNIVILSDMMIAEGYSDINVRGSSIVNSIKKYKDEVNPNIKIFAVDLEGYGKCLNLGDEFNENNYIKIFGMSDSILKFISAKQGGANMVEVIKNFALQKIGQK
What is the function of this protein?
Ribonucleoprotein DNA polymerase that catalyzes the de novo synthesis of telomeric simple sequence repeats.  Subunit p80 binds tightly and specifically to the telomerase RNA suggesting its association with a region of RNA secondary structure.
What are the official names of this protein?
Telomerase component p80.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: SOCS2_PIG
Sequence: MTLRCLEPSGNGAEGTQSQWGTSGSAEEPSPEAARLAKALRELSHTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPPLQHLCRLTINKCTGTIWGLPLPTRLKDYLEEYKFQV
What is the function of this protein?
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.  SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway (By similarity).  Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Suppressor of cytokine signaling 2, SOCS-2.
Protein: VL1_HPV08
Sequence: MAVWQSATGKVYLPPSTPVARVQSTDEYIQRTNIYYHANTDRLLTVGHPYFNVYNNNGDTLQVPKVSGNQHRVFRLKLPDPNRFALADMSVYNPDKERLVWACRGLEISRGQPLGVGSTGHPYFNKVKDTENSNSYTTTSTDDRQNTSFDPKQIQMFIVGCTPCIGEHWEKAIPCAEDQQQGLCPPIELKNTVIEDGDMADIGFGNMNFKTLQQNRSDVSLDIVNEICKYPDFLKMQNDVYGDACFFYARREQCYARHFFVRGGKTGDDIPAAQIDDGMMKNQYYIPGGQDQSQKDIGNAMYFPTVSGSLVSSDAQLFNRPFWLQRAQGHNNGILWANQMFVTVVDNTRNTNFSISVYTENGELKNITDYKSTQFREYLRHVEEYEISLILQLCKIPLKADVLAQINAMNSSLLEEWQLGFVPTPDTPIHDTYRYIDSLATRCPDKSPPKEKPDPYAKFNFWNVDLTERLSLDLDQYSLGRKFLFQAGLQQTTVNGTKSISRGSVRGTKRKRKN
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: HVCN1_CHICK
Sequence: MSRYLKHFTVVGDDPIQWSNDYQKWENEEEDNGEKDSEIKLEPSRGHVTFQDVMKKLFSSRRFQIVIVFLVIVDALLVLGELLMDLKIIHPDKYHIAPKVFHYLSLSILTIFLVEVGFKIFVYGREFFHHKFEVLDSIVVVVSFILDLVLLFREHEFEAVGLLILLRLWRVARIINGIILSVKTRSEQQVSKLKQVNLKLATKVEQLQHSCVEKEQEIERLTRMLKQHGLLSEQT
What is the function of this protein?
Mediates the voltage-dependent proton permeability of excitable membranes.  Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).
What are the official names of this protein?
Voltage-gated hydrogen channel 1, Hydrogen voltage-gated channel 1, HV1.
What is the protein family that this protein belongs to?
Belongs to the hydrogen channel family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: Y240_THEPX
Sequence: MLLEYIDEVYKSVEKIKATQIKNIQEAAMLIANSLLKEEDSVFHVFGCGHSHMAAEELFYRAGGLACVNPILPSELMLHEGALKSSYYERNEDIIKLIFDRYDLRQGECIIIVSHSGRNGAPIEAAIEAKRRGLKVVAITSKEYKQKTFSRHSSGKFLEDITDIVIDNCGHYGDAVLKIKKDTLEISFSPLSTVLNTIILNMIEAEIVSIMIKKNLVPPVFLSGNIEGADEHNLKLIEKYKKRVKHL
What are the official names of this protein?
UPF0309 protein Teth514_0240.
What is the protein family that this protein belongs to?
Belongs to the UPF0309 family.
Protein: RT25_PICGU
Sequence: MKVQTGATGVLERTSHYLKAGLLRTKPAWFDVVGAHPPSTNLTKKPKLFETGGQKSDPSESIFTKINGEYKTRTSVEDRKQKNNSVSRVPKLQFLEDQLRDVFYHQHPWEFSRPKVLVETSGDDNSKCDWSHMLQFNKPLDGESVVQRTLWLLNRSKMDGKSITLFDAYDEARFEFYRLRMEEEMSSAVSREESTMYGAVFPSPHLEHGVNQEQEYIDIWTKVAGDATKVKTASKDGKSSNGSMGAEDVVEKTTSAWETEFVEEESS
What are the official names of this protein?
37S ribosomal protein S25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS23 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: WASF3_HUMAN
Sequence: MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNPVADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNRPQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSRRIAVEYSDSDDDSEFDENDWSD
What is the function of this protein?
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.  Plays a role in the regulation of cell morphology and cytoskeletal organization.  Required in the control of cell shape.
What are the official names of this protein?
Actin-binding protein WASF3, Protein WAVE-3, Verprolin homology domain-containing protein 3, Wiskott-Aldrich syndrome protein family member 3, WASP family protein member 3.
What is the protein family that this protein belongs to?
Belongs to the SCAR/WAVE family.
Protein: Y869_BACLD
Sequence: MDQLKYPIGTFSKPLEADERELEKWIGDLKQAPHLLRSAAAELNEEQLDTPYRTGGWAVRQVVHHLADSHMNGYIRSKLALTEETPLIRTFDEQNWAGLTDARTLDPDLSLALLDTLHLRWAALXESLTEADFEKAYIYPGTGEEMKLYQALALYVWHSQHHIAHIKAHRKRMGWN
What is the function of this protein?
Possible metal-dependent hydrolase.
What are the official names of this protein?
Putative metal-dependent hydrolase BLi00869/BLi00870/BL03027.
What is the protein family that this protein belongs to?
Belongs to the metal hydrolase YfiT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_STRPF
Sequence: MKKRIKELTDLLNRYRYDYYTKDAPSVSDSDYDKLYRELVTLEQSYPEYVLQDSPTQQVGGTILKGFEKYRHQYPLFSLQDAFSREELDAFDKRVKAEFPNATYLAELKIDGLSISLSYENGFLQVGATRGDGNIGENITENIKKIKDIPHQLSEPLTITVRGEAYMSRQSFKAINEARQENGETEFANPRNAAAGTLRQLDTAVVAKRQLATFLYQEASPTARNQQNEVLAELADLGFSVNPYYQLTSSMDEIWDFIKTIEAKRDQLAYDIDGVVIKVNSLAMQEELGFTVKAPRWAIAYKFPAEEKEAEILSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRIGDTVIVYKAGDIIPAVLNVVMSKRNQQEVMLIPKLCPSCGSELVHFEDEVALRCINPLCPSLIQRSLEHFASRDAMNITGLGPAIVEKLFLAGFVHDVADIYQLTKENFMQLDGIKEKSADKLLAAIEASKSNSAEKLLFGLGIRHIGSKVSRLILEVYGDISALLTAKEEEIARIDGLGSTIAQSLTQYFEQKTAAILVDELKTAGVNMHYSGQKVNSDAALFGLTVVLTGKLNQLNRNEAKDKLEALGAKVTGSVSKKTDLVIAGSDAGSKLEKAKSLGIRIEDEDWLRQL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RS8_PELPD
Sequence: MSMTDPIADMLTRIRNANMVKHQKVDIPSSTMKVNIASVLKQEGYIKNYKVISDNLQGILRVYLKYIDDKDGVINEIKRISKPGGRVYVKADEVPTVKSGLGVVILSTSKGIITDSAARKAGLGGEIICTVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.