PharMolix/UniProtQA huggingface dataset:
Protein: RRAA_ECO45
Sequence: MKYDTSELCDIYQEDVNVVEPLFSNFGGRASFGGQIITVKCFEDNGLLYDLLEQNGRGRVLVVDGGGSVRRALVDAELARLAVQNEWEGLVIYGAVRQVDDLEELDIGIQAMAAIPVGAAGEGIGESDVRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_UREPA
Sequence: MAVKRIKNHSSGKRQTVVVDYKSILTTSKPEKSLLVTLPKKAGRNNQGKITIRHHGGGHKRKYRIIDFKRNKDNIYGTIKSIEYDPNRTSFISLVVYADGEKRYIIAPKGIKVGDKIISGNENIDILLGNSLPLEFIPEGTLVHNIELSPNAGGQITRSAGASAQILGFDETKKYILVKLNSGEVRKFRKECRATIGTVSNDEHILENLGKAGKSRHLGVRPTVRGSAMNPNDHPHGGGEGRSPVGMDAPRTPWGKRHMGVKTRNNKKSSTSMIVRRRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: THYX_THEON
Sequence: MRDGIKVRLVNYTKKPLETVTWAALISYWDEWETEAFERLGEKDVEMHLPRILGYGHESILEHAVLTFAIEGCSRVCSHQLVRHRIASYTQQSMRYIKINPRDVEETFVIPESVKKNPELYEKWKKLMRETIQLYEETYKAGVHQEDARFILPQAVRTKIVVTMNLRELKHFLGLRACERAQWEIRDVAWKMLGEIAKNEELRPIIRWAKLGPRCVQLGYCPEGELMPPGCWKRTREKWKEVALG
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: HYCE_ECOLI
Sequence: MSEEKLGQHYLAALNEAFPGVVLDHAWQTKDQLTVTVKVNYLPEVVEFLYYKQGGWLSVLFGNDERKLNGHYAVYYVLSMEKGTKCWITVRVEVDANKPEYPSVTPRVPAAVWGEREVRDMYGLIPVGLPDERRLVLPDDWPDELYPLRKDSMDYRQRPAPTTDAETYEFINELGDKKNNVVPIGPLHVTSDEPGHFRLFVDGENIIDADYRLFYVHRGMEKLAETRMGYNEVTFLSDRVCGICGFAHSTAYTTSVENAMGIQVPERAQMIRAILLEVERLHSHLLNLGLACHFTGFDSGFMQFFRVRETSMKMAEILTGARKTYGLNLIGGIRRDLLKDDMIQTRQLAQQMRREVQELVDVLLSTPNMEQRTVGIGRLDPEIARDFSNVGPMVRASGHARDTRADHPFVGYGLLPMEVHSEQGCDVISRLKVRINEVYTALNMIDYGLDNLPGGPLMVEGFTYIPHRFALGFAEAPRGDDIHWSMTGDNQKLYRWRCRAATYANWPTLRYMLRGNTVSDAPLIIGSLDPCYSCTDRMTVVDVRKKKSKVVPYKELERYSIERKNSPLK
What are the official names of this protein?
Formate hydrogenlyase subunit 5, FHL subunit 5, Hydrogenase-3 component E.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
Protein: RL17_VIBCM
Sequence: MRHRKSGRQLNRNSSHRKAMFSNMASSLVRHEVIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEVVAKLFNELGPRFAARQGGYTRILKCGFRAGDKAPMAYIELVDRPEAAVEAAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: QUEC_XANC8
Sequence: MKKAVVLLSGGMDSAAVIALAQEQGFAVHALSVRYGQRHTSELDAAARVAAAQGVVAHKVVDVDLRSIGGSALTADIDVPEAGGAGIPVTYVPARNTIMLSLALGWAEVVGANDLFCGVNAVDYSGYPDCRPEFVRAFEVLANLATKAGVEGAGLRVHAPLQFLSKADIVRAGVRLGVDFGLTVSCYNADADGRACGHCDACRLRAAGFADAGVPDPTHYAISS
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: MTNN_HAES1
Sequence: MKVGIVGAMAQEVEILASLIENKNVVHIAGCTIYQGNIQDKEVALLQSGIGKVAAAMGTTLLLQMFKPDIVINTGSAGGVSSGLKVGDVVVSTQTVYHDADVTAFGYAKGQLPACPPAFISDPKLTALVANVAKQQGINLTSGLICSGDSFINSAEKLAWIKANFPEVVAIEMEATAIAQVCHKFNIPFVVIRAISDVGDGEASMSFEEFLPLAAKQSSSMVLKILQSL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: MEIOB_MOUSE
Sequence: MAKFFALKNFTALSDLHPNMANLKIIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPCHFVNVSSWGSEDYIRSLSESFRVAECVIIENPLIQRKDTEREEKFSPATPSNYKLLLSENHSMVKVCSPYEVDTKLLSLIHLPVKESRDYYSLADIVANGHSLDGRIINVLAAVRSVGEPKYFTTSDRRKGQRCEVKLFDETEPSFTMTCWDNESILLAQSWMARETVIFASDVRINFNKFQNCMAATVISKTIITVNPDTPEANILLNYIRENKETNVADEIDSYLKESVNLNTIVDVYTVEQLKVKALKSEGKADPFYGILYAYISTLNIDDETTKVVRNRCSSCGYIVNEASNTCTICNQDSSRLKSFFLSFDVLVDLTDHTGTLHSCSLSGSIAEETLGCTINEFLTMTSEQKTKLKWQLLLERSKIYLKLILSHRARGGLKVTILSCKLADPTEASRNLARQGHT
What is the function of this protein?
Single-stranded DNA-binding protein required for homologous recombination in meiosis I.  Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis.  Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage.  May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination.  Displays Single-stranded DNA 3'-5' exonuclease activity in vitro.
What are the official names of this protein?
Meiosis-specific with OB domain-containing protein, Protein expressed in male leptotene and zygotene spermatocytes 675, MLZ-675.
What is the protein family that this protein belongs to?
Belongs to the MEIOB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome. Note=Co- localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22.
Protein: SUCC_GEOKA
Sequence: MNIHEYQAKEILRSYGVSVPNGRVAFTVDEAVEAAKELGAPVCVVKAQIHAGGRGKAGGVKVAKSLEEVRTYASELLGKVLVTHQTGPEGKEVKRLLIEEGCDIQKEYYIGLVVDRATSRVVLMGSEEGGTEIEEVAAKTPEKIFKEYIDPAVGLQAFQARRLAFNINIPKHLVNQAVKFMMGLYQVFVDKDCSIAEINPLVVTGDGKVMALDAKLNFDSNALYRHPDILEYRDLDEEDPKEVEASKYDLNYIALDGNIGCMVNGAGLAMATMDIIKYYGGEPANFLDVGGGASEEKVREAFKIILSDPNVKGIFVNIFGGIMKCDVIASGIVAATKQVGLTLPLVVRLEGTNVELGKKILQESGLNIIAAESMADGAQKIVELVR
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: MUP1_MOUSE
Sequence: MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEKHGILRENIIDLSNANRCLQARE
What is the function of this protein?
Binds pheromones that are released from drying urine of males.  These pheromones affect the sexual behavior of females.
What are the official names of this protein?
Major urinary protein 1, MUP 1.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GSEP_BACLD
Sequence: MVSKKSVKRGLITGLIGISIYSLGMHPAQAAPSPHTPVSSDPSYKAETSVTYDPNIKSDQYGLYSKAFTGTGKVNETKEKAEKKSPAKAPYSIKSVIGSDDRTRVTNTTAYPYRAIVHISSSIGSCTGWMIGPKTVATAGHCIYDTSSGSFAGTATVSPGRNGTSYPYGSVKSTRYFIPSGWRSGNTNYDYGAIELSEPIGNTVGYFGYSYTTSSLVGTTVTISGYPGDKTAGTQWQHSGPIAISETYKLQYAMDTYGGQSGSPVFEQSSSRTNCSGPCSLAVHTNGVYGGSSYNRGTRITKEVFDNLTNWKNSAQ
What is the function of this protein?
Specific for hydrolysis of peptide bonds on the carboxyl side of acidic amino acid residues, with a strong preference for Glu.
What are the official names of this protein?
Glutamyl endopeptidase, Glutamate-specific endopeptidase, GSE.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1B family.
What are the subcellular locations of this protein?
Secreted.
Protein: CP4F4_RAT
Sequence: MPQLDLSWLGLRLETSLPWLLLLLIGASWLLVRVLTQTYIFYRTYQHLCDFPQPPKWNWFLGHLGMITPTEQGLKQVTKLVATYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDGDKWSCHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSARLDMFKNISLMTLDSLQKCVFSFDSNCQEKPSEYISAILELSALVAKRYQQLLLHTDSLYQLTHNGRRFHKACKLVHNFTDAVIQGRRRALPSQHEDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSTQ
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its oxygenated derivatives (PubMed:14634044, PubMed:9344476, PubMed:17418803).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:14634044, PubMed:9344476, PubMed:17418803).  Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:14634044).  Hydroxylates the terminal carbon (omega-hydroxylation) of inflammatory lipid mediators, including prostaglandin (PG) A1, PGE1 and leukotriene B4 (LTB4), and may play a role in inactivation of these oxylipins during the resolution of inflammation (PubMed:14634044, PubMed:9344476, PubMed:17418803).
What are the official names of this protein?
Cytochrome P450 4F4, CYPIVF4, Leukotriene-B4 20-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein: NUSB_DESHD
Sequence: MSRRLARETALQVLFQLEMTGESQDLKSAIHKWADEFAVPEGSIPFAEELAEGTLTHKEVIDENLEKLSEGWSLARMANVDRNLLRLASYEILFRKDIPGRVTINEAIEIAKRYGSEESGKFINGILDKVVESVNKKDEKGNDTLSRD
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: T4G1K_AGEOR
Sequence: MRTIISLLLLSAMVFAVIEAISLEEGLQLFEGERGCVGENQQCADWAGLHCCSGYYCTCRYFPKCICRKDSGK
What is the function of this protein?
Insecticidal neurotoxin that modulates the insect Nav channel (DmNaV1/tipE (para/tipE)) in a unique manner, with both the activation and inactivation processes being affected.  The voltage dependence of activation is shifted toward more hyperpolarized potentials (analogous to site 4 toxins) and a non-inactivating persistent sodium current is induced (site 3-like action).  Interestingly, both effects take place in a voltage-dependent manner, producing a bell-shaped curve between -80 and 0 mV.  Compared to beta/delta-agatoxin-1 to -3, this toxin appears to affect the insect sodium channel only weakly.
What are the official names of this protein?
U3-agatoxin-Ao1k, U3-AGTX-Ao1k, Beta/delta-agatoxin-4, Mu-2Aaga_12.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 07 (Beta/delta-agtx) family. 03 (aga-4) subfamily. Aga sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: URED_STRE5
Sequence: MTQAYDGFVHLGFSNRNGRTISHKKYQEGNSRVSADNSDANGVPYYFLINMGGGFVEGEQYQVTIDVNKDAHALVTTQTPTYVYKCEKGQLTHQNTSITLEENSYLEYMADEVIPYLRSRYFQTSRIDMDKSAHLIYSDGVTAGWSHEDLPFQYHYFRNLTQIYQDDELVYSDQTLLEPQKQDMFKLGYFEGWRNYNSLVMVSPNIDEAFVKALQKHLENLNLESDFAISSLDIPGLVLRILGKTAEDNRRVIYSCADYFRQEIHGLTPLNLRKNDMRR
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPCH_SALSV
Sequence: MKNAFKDALKVGRPQIGLWLGLANSYSAELLAGSGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
What are the official names of this protein?
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: OAT_BOVIN
Sequence: MLSKLARLQTVAGLGLGVHSSVASATSVATKKTVQGPPSSDYIFERESKYGAHNYHPLPVALERGKGIYVWDVEGRKYFDFLSAYSAVNQGHCHPKIVDALKSQVDKLTLTSRAFYNNVLGEYEEYVTKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIPKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFEIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLVGVRELCTQHQVLFIADEIQTGLARTGRWLAIDHENVRPDIVLLGKALSGGLYPVSAVLCDDEIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENAEKMGIILRNELMKLPSDVVTTVRGKGLLNAIVIRETKDCDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDEILEAVEIINKTILSF
What is the function of this protein?
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.
What are the official names of this protein?
Ornithine aminotransferase, mitochondrial, Ornithine--oxo-acid aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CB1B_ARATH
Sequence: MAASTMALSSPAFAGKAVNLSPAASEVLGSGRVTMRKTVAKPKGPSGSPWYGSDRVKYLGPFSGESPSYLTGEFPGDYGWDTAGLSADPETFARNRELEVIHSRWAMLGALGCVFPELLARNGVKFGEAVWFKAGSQIFSDGGLDYLGNPSLVHAQSILAIWATQVILMGAVEGYRVAGNGPLGEAEDLLYPGGSFDPLGLATDPEAFAELKVKELKNGRLAMFSMFGFFVQAIVTGKGPIENLADHLADPVNNNAWAFATNFVPGK
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein 3, chloroplastic, Chlorophyll a-b protein 180, CAB-180, LHCII type I CAB-3.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: Y1849_AQUAE
Sequence: MKAYLFIFIFLFLLNFLILFFVLKTELIVSSLIAGGYALFVSAFTSYVYTKKVEKLLGVLLYFAEFVYENRQNLEGSVFYSPLYEELRDIVSYIEGGIKNVKSSLEKQLADVHVEYTEVVEKLGQIMEVVERLKQGEIEYGALPTGLDPAGALGEILRESLSEIAKKIDNIKRKIYELDDTIKKVKNYAEAGEEELVKAEITRTKSILEEIEKELEFFK
What are the official names of this protein?
Uncharacterized protein aq_1849.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: YO379_YEAST
Sequence: MNLFYKMLLFGDPFFRLHKSAPCIRCCDKNAKSAQPDAHVPRTTISFQRLGTSVIYSRFNCTCNTQTYRYRIVYHRINQRGCKTLMFVWHRVTKHYCSGRKGHVHSPRHNND
What are the official names of this protein?
Putative uncharacterized protein YOR379C.
Protein: EX7L_STUS1
Sequence: MLKDPFQRLNLDREVLTVSQLNGRARLLLEDVFAQVWVEGEISNLARPASGHVYFTLKDRNAQVRCALFRQNAARVRQALRDGLAVRVRGKVSLFEGRGDYQLILDMLEPAGDGALRLAFEALKEKLAAEGLFSAERKAALPAHPRRIGIVSSPTGAVIRDIISVFRRRAPQVELTLIPTAVQGREATGQIVRALQLADAQGFDALILARGGGSLEDLWCFNEEAVARAVDACVTPIVCAVGHETDVSIADFVADVRAPTPSAAAELLAPSSADLQQRLNGLQQRLVLRMRDRLHRDAMRLDGLTRRLRHPGERLQQQAQRIDDLEQRLLRALDRRLCSGQERLARLETRLAAQHPGRTLNLLRQRLDHLSSRLPRAMQANIKGRRQQLQGLAQTLNVVSPLATLSRGYSILLDDRGQAIRSASQTQPGQRLKARLGDGELDVRVEDNHLQPVTLPLL
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
Protein: CML45_ARATH
Sequence: MESKSSSSSLPLFALFNFFLISFCRWVSSTRIFLSRFVPLLQHHQRVFDKKNNKDQQETLTKQEDDDDDDDDDDDDDDDDIDISREEAEMVMRSLGLFYNDDQLQEQYSAKEVSSLFEEKEASLEEVKQAFDVFDENKDGFIDAIELQRVLTILGFKQGSYLDNCLVMIRSLDGNKDGKIDFNEFVKFMETSFY
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML45, Calmodulin-like protein 45.
Protein: MDM10_ASPFC
Sequence: MLDFMDYIQLAFAEATNWNRDNSYSSLTATAQSLLDFSTPERLRVHLSSLATPHFATSYTLGTVGLIDGSVSYLYSTVPLNNTPSRSALIPLRKLARGYRQVQPPVAPVEDCGWQSCLGGLGSSESKPSGNDDSQPSLGRKATLLNATLHLPPPTILNALFLRRMSPTMQLSLAVCSTRGAPLSNSAPQASLLGQLSHDTGKYSNEYLFSTDNSLFGWRGLWNFGPDPRHPKENSSPQLSLLSAGAEAYYSPVSSLIGMSTGLRFSTLPAATEMPSSSSSASSTTTTSNHGTPISTFPYTLTLVLTPLTGSLSTTYSLRASPNLAFSSRFGFNVYSWESEMVAGCELWRKRRKPSPPPVDDDGLEWARRKMRMADTPAFAPVEPPTTHNRDEENESVLKIRVDQSWNVRLLWEGRVKELLVSAGVGLGPSSFSSPSRAANSTPAGGGQSVGGGISGRSYWHGVGVSISYSS
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the receptor tom22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the mdm12-mmm1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the tom40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component mdm10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: RRS1_MOUSE
Sequence: MEGQRVEELLAKAEQEEAEKLQRITVHKELELEFDLGNLLASDRNPPTVLRQAGPSPEAELRALARDNTQLLINQLWRLPTERVEEAVVARLPEPATRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEASGQWRRRWGYKRARDDTKEWLIEVPGSADPMEDQFAKRTQAKKERVAKNELNRLRNLARAHKMQMPSSAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKAPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPRLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPSGKRKGGPPGQGEKRKGGLGSKKHSWPSALAGKKKGVPPQGGKRRK
What is the function of this protein?
Involved in ribosomal large subunit assembly.  May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.
What are the official names of this protein?
Ribosome biogenesis regulatory protein homolog.
What is the protein family that this protein belongs to?
Belongs to the RRS1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: COX1_DICDI
Sequence: MKILEIYDKQIAEKEGNIFIFISKWIISVDHKNIGTMYTNFSILAGIVGTLLSLVIRMELSTGNMLDGDGQQYNVIVTAHGLIMIFFVVMPAMLGGFANWFIPIMVGSPDVAFPRLNNISLWLIIVSFFLLLTSSCVGIGVGTGWTVYPPLSTMEYHPGHAVDVGILSLHIAGASSLLGAINFLTTVFNMKIAGLSWSKVSLFVWSILITAVLLVLSLPVLAGGLTMLITDRNFETTFFDPIGGGDPILYQHLFWFFGHPEVYILILPGFGLVSIILSKYSNKGIFGVKGMISAMSAIGFLGFLVWAHHMYTVGLDVDTRAYFTAATMIIAIPTGIKIFSWLATLWGGVIKITTPMLFVIGFLVLFTIGGLTGVVLANGGLDISLHDTYYVVAHFHYVLSMGAIFAIFAGYYYYYSIMNSTRLFGVVRYNEQLGRIHFWTMFIGVNVTFFPMHFLGLAGMPRRIGDYPDAYIGWNLIASYGSLITAFGLLFFVVNIFTPYIRRSVNIKNGAIILMGLDFARDWQIGFQDPATPIMEGIIDLHNYIFFYLIVVAVFIGWVMGRILWRFSYKWSYPTIGDIEIFKNFTAYNQIIHGTVIEIVWTLIPTVILYLIAIPSFTLLYAMDEIINPTVTIKIIGHQWYWSYEYGDNASNLIEFDSYMVYERDLAEGQLRLLEVDNAMVVPVKTHIRLIITSGDVLHSWAIPSFGIKVDAVPGRLNQIGLYVKREGTFYGQCSELCGVDHGFMPIKVQAVKLGEYFSKLNEK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1+2, Cytochrome c oxidase polypeptide I+II.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BIOC_MAGMM
Sequence: MNLPNRGEGNRNGRVGKNFGRALNYHRKALVQQHVADELAERLVDFPLPERPRVLEIGCGTGFLSRHLMRQWPGGSFLFTDISAPMLVRCQSHLSDLPGQRQFMVMDGEHCAVRGPFDLVVSSMAMQWFGDLPGALQGLSSLLKTNGMLAFATLGDETFREWRGVCAQYGSPFGRPDYPDVAQLQEMWPSGGEGDVEEDHIPVAHSSGHGFLRALREVGAHQPSGQHRPVSAALMRRMLQATRGGQHGFTVTYHVLYGFYTRSFDDRPIH
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase, Malonyl-ACP O-methyltransferase, Biotin synthesis protein BioC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.