PharMolix/UniProtQA huggingface dataset:
Protein: ABAA_EMENI
Sequence: MATDWQPECMVSQNQAALESIGAHSDRALQNTSGNVQAYSDSLAHHDTTGRDDPLQHYTLKYPHPPVPVPSHPLPTATANLYHPQLLSHRYQVKKLRRLQSNGSSYAGSRRGRSYLKSQKYLEYRARPRRDTGKDGEPVWSDELEDAFQQALEANPPMGRRKWSERGKSYGRNELIAEYIYKLTGKRRTRKQVSSHLQVLDSFLKGDPDWERLVREQSDRSTAQTQPVGPRWRTSMDHLPSSHYGTHATSSYPEPMRLMPPYSADLQLPQYSPTSTQQDTNNNTIQGLSFDMWVSAPNKPDRIDDAYHLYTRLQGDQRQPPMPLEDLKNWRVSFPHLSSSLSDVNDPLNCEIILLETNLELMDDFPPMGSRLGIHLELDIANPMSGTAPTVNQMENWTCSTYIYEDGRRTMEAYHNLTKPHTTKVKPPFESSWWAKTFTKLTQDKREAESTGHHHAADERTRRYFHSLTAVQEIRATVPPSLRRLQNHYPGSPAEESKRMAIILWKFRQTRPNEVGTTTWRKLITSPDRALTNSPRPSTAIDLPPLSLDSILLSKPTSNLYQAPPQHHDLLHQNAPSQQSWSLYQPSHDHVNSLYHSAGAFDFLNSITKPEEGLSDKTAPTSVLDPFPNLTQQTTSQTAGINVSSGTPVMLQIPDLSLSSNLGTYGLGHESHYVPSHHNAANLHDHSSTTGLGHYFAPSTQSLDEISHSHAPWSAPNTTISGDTSGGNYHHLPFTTSDHSVTVSRESHQNHSFEGLLPSDDLVGIVGGLSGDPNMNGAGPEHTSSAYAEHTAVEAV
What is the function of this protein?
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (PubMed:2655931, PubMed:2196567).  They act individually and together to regulate their own expression and that of numerous other sporulation-specific gene (PubMed:2655931, PubMed:2823119).  Controls temporal and spatial specificity in Aspergillus development (PubMed:2655931, PubMed:7704830).  Directs the differentiation of phialides and is continuously required for maintenance of their function (PubMed:2152124).  Expression of abaA leads to activation of brlA and wetA, cessation of vegetative growth, and accentuated cellular vacuolization (PubMed:2655931).  Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (PubMed:8139553).  Multiple abaA binding sites are present in the cis-acting regulatory regions of several developmentally controlled structural genes as well as those of the upstream regulatory gene brlA, the downstream regulatory gene wetA, and abaA itself (PubMed:8139553).
What are the official names of this protein?
Conidiophore development regulator abaA.
What is the protein family that this protein belongs to?
Belongs to the TEC1 family.
What are the subcellular locations of this protein?
Nucleus. Note=localizes to the nuclei of phialides and terminal cells of mature conidia (By similarity).
Protein: BPT_PSEA6
Sequence: MKFGISQSFPCSYLPDEQETLLVYAEETEHNTYYEMLMAAGFRRSGAQVYRPHCGACTACQAIRVPVADFAPSKGQKRILKRNSDITVVLSEQDKAHYYSLYEKYINTRHQDGSMYPATPEQYASFAHGDWLDPLYIELHLSGELVGIAVTDALENALSAVYTFFEPSLAERSLGTFAVLQQISIAKRLNKQHLYLGYQIDNCQKMQYKRNFLPHERFIEQKWQLISKKDW
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_BACP2
Sequence: MNAGIIGLGRYIPEKVLTNLDLEKMVETSDEWIRTRTGIEERRIASDDVNTSHMALAAAKKALADADVAAEDIDMILVATVTPDQAFPTVACMIQEQLGAHKACAMDISAACAGFMYGLVTGKQFIESGTFKHVLVVGVEKLSRITDWDDRNTAVLFGDGAGAAVLGEVSEGKGILSFELGADGRGGKHLYLDEKDHTIMNGREVFKFAVRQMGESSVNVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPISLCEEIEAGKIHDGDVIVMVGFGGGLTWGAIAMRWGR
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DES1_CRIDS
Sequence: GLADFLNKAVGKVVDFVKS
What is the function of this protein?
Has antibacterial activity against the Gram-positive bacteria L. lactis (MIC=25 uM) and S. uberis (MIC=50 uM).  Lacks antibacterial activity against the Gram-negative bacteria E. cloacae and E. coli, and against the Gram-positive bacteria B. cereus, E. faecalis, L. innocua, M. luteus, S. aureus and S. epidermidis.  Inhibits the formation of NO by neuronal nitric oxide synthase with an IC(50) of 2. 4 uM.
What are the official names of this protein?
Deserticolin-1.
What are the subcellular locations of this protein?
Secreted.
Protein: HEM1_MARSD
Sequence: MDHNIYLIGLNHRSAGVDVRERYALTNVEEFESGLLELGVREVMALSTCNRVEILVVCAPEITQPNILEYWAKRCCGSVSELEPNTYCHDGLNAVKHLFRVACSLDSMIVGEPQILGQLKDSYRKAVEAGAARVIINRMLHKSFFVAKRVRTETSIASSAVSISYAAVELAKKIFGELEGQRAMLIGAGEMAELAATHLLNSGVEQISIANRTYSRAEDLAKCMGGSAVSFDNLYDHLVETDIIISSTGAPHAVISAKEMKKVIKKRKYRPMFFIDIAVPRDIDPDVNGLDNVYLYDIDDLKDVVEENKSQREDEAIKANSIVEFETLSFGNWINSLDLQPTIVDLFNRSENVAQQELAKTLKRLGDVDAKTHKALETMAMSIGKKLLHEPVAFLKRRTEEEGKADEFVDLARRMFNLDNETIPADAHCGRKKNRNPEN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: P2A14_ARATH
Sequence: MGAASSSIVRSEPFAGKLCGLEDVPENCITAMFMYMEPPEICLLARVNKSFHRASRSDAVWEDKLPSNYKFLVRRILEDQQQVGVKDKLIYRKKEIYARLCRPNLFDTGTKEAWLDKRSGKVFLAISPKAMKITGIDDRRYWEHISSDESRFGSITYLRQIWWLEAVGKIRFEFAPGKYSLLFKIQLGKPIRKCGRKTCSLDQVHGWDIKPVRFQLSTSDGQCAMSERHLDESGRWVYHHAGDFVVENQNSPVWVKFSMLQIDCTHTKGGLCLDCVIICPFEYRGKYKYSD
What is the function of this protein?
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
F-box protein PP2-A14, Protein PHLOEM PROTEIN 2-LIKE A14, AtPP2-A14, SKP1-interacting partner 13.
What are the subcellular locations of this protein?
Nucleus.
Protein: AF1L2_MOUSE
Sequence: MERYKALEQLLTELDDFLKVLDQENLSSAAVLKKSGLSELLRLYTKSSSSDEEYIYMNKVSVNGEQNSASPDKVPEEQGPLTNGEPSQHSSAPQKSLPDLPPPKMIPERKQPTVPKIESPEGYYEEAEPFDRSINEDGEAVSSSYESYDEDENSKGKAAPYQWPSPEASIELMRDARICAFLWRKKWLGQWAKQLCVIRDTRLLCYKSSKDHSPQLDVNLRGSSVVHKEKQVRKKGHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRLNCQKPDIAEKYLSAAEYGITINGHPEIPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPPERSLETSSYLNVLVNSQWKSRWCFVRDSHLHFYQDRNRSKVAQQPLSLVGCDVLPDPSPDHLYSFRILHNGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEELTYDYVDAERVSCIVSAAKTSLLLMQRKFSEPNTYIDGLPSRDCQDDLYDDVEVSELIAVVEPAEEAAPAVDANSGSEPDRVYLDLTPVKSFLHSSSEAQAQASLPAVPHQDDVAETLTVDPKPGTTPEEPHTESPGDPEVQQRQPEVQESSEPIEPTPRITMVKLQAEQQRISFPANCPDTMASAPIAASPPVKEKLRVTSAEIKLGKNRTEAEVKRYTEEKERLERSKEEIRGHLAQLRREKRELKETLLRCTDKGVLAKLEQTLKKIDEECRMEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVDTTHLDNMSPRPQPKAATPNPPPDSTPVNSASVLKNRPLSVMVTGKGTVLQKAKEWEKKGAS
What is the function of this protein?
May play a role in a signaling cascade by enhancing the kinase activity of SRC.  Contributes to SRC-regulated transcription activation (By similarity).
What are the official names of this protein?
Actin filament-associated protein 1-like 2, AFAP1-like protein 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMT2_SCHPO
Sequence: MLTLNSTIKSVTGSFQSASMLARFASTHHKVLVVGGGSAGISVAHQIYNKFSKYRFANDQGKDTSLKPGEIGIVDGAKYHYYQPGWTLTGAGLSSVAKTRRELASLVPADKFKLHPEFVKSLHPRENKIVTQSGQEISYDYLVMAAGIYTDFGRIKGLTEALDDPNTPVVTIYSEKYADAVYPWIEKTKSGNAIFTQPSGVLKCAGAPQKIMWMAEDYWRRHKVRSNIDVSFYTGMPTLFSVKRYSDALLRQNEQLHRNVKINYKDELVEVKGSERKAVFKNLNDGSLFERPFDLLHAVPSMRSHEFIAKSDLADKSGFVAVDQSTTQSTKFPNVFAIGDCSGLPTSKTYAAITAQAPVMVHNLWSFVNGKNLTASYNGYTSCPLLTGYGKLILAEFLYKQEPKESFGRFSRFLDQTVPRRMFYHLKKDFFPFVYWNFAVRNGKWYGSRGLIPPHFPVN
What is the function of this protein?
Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone.
What are the official names of this protein?
Sulfide:quinone oxidoreductase, mitochondrial, Cadmium resistance protein 1, Heavy metal tolerance protein 2.
What is the protein family that this protein belongs to?
Belongs to the SQRD family.
Protein: RFIP3_DANRE
Sequence: MEQVLSSPQGCSEWEVNGKTEWESDQNPLGFLLVDKENSSVADPTNEIFQENAINLDDLFWASQTYSWENGLDCVYPEWKAQPPPSQDLKGDGNSGISQLVEGDLICFNSRSASPSLADRPVQDNNLYDHAEQVEVTATSSTLNVCTGELGINAPTLHTDKTLLQDTHLMLEESHLTNCEFSCNSGVENESQNFLSHGTRNILESEGLFAVSPVEVSCVDTNSNPKPTIVCQTPPLASEHIYLSSSALPCEPVFPMTCTKPHVPPYHAGSATLPMDEVEMMLPKLQGGEGESSKPSANNRTLEPQRLDANTDTTHLSVCPLGESDISPEHCEEMLHELSTKCTVEMVEEEVNKKSVSSNTTNTAFSKPKTELCEELSGCTLGVLLETVSGDVKEEAASDSRTDHVFPETQTDLAPVALIDSQAEDPSTESLPRKNGQEESKSALPVSTPEHNALFELSSGNVVLPEDHSQSTFSAQTQALSEVDHDGDLTPDGMLTDNIVCEAVTSIDSVILSLTDSFELPKLSDCDLSSHDFESHALTLEIQNNVTCVQTGSVDNNPEEMSTPFTCTDNQLTVTGGLAGLDLTETTSQSGEASGEGEAGLPVLPTHQEDFHQLTPSEINLAQEQQVSSVVPSSPPSHRDVFPCGASLDGEAYLTLMENNPDTLKHAEMTLDLCKASDALPTKSLQIAPVDLIHVPIVSATAPRSEEQSALRAVFQALDQDGDGFVHIEEFIEFAKAYGAEQVKDLTRFLDPSGLGVISFEDFHRGISAISNEESAYSECETFTDEDTTALVHPELHEDVETDSGIENTLTDGDDRNSPSSFPASFQNFLQSEALEFFCTHCHKQISRLEDLSTRLQLLEMNRHLQQSNNLDVMGDLTQDILDLADRDITDKVLLLEKRVCELEKDSLESEEQHARLRQENLTLVHRANALEEQLKEQELRTEEDLLAQTRKHRDALNKLQRERDLEIENLQARLHQLDEENSELRSCVPCLRANIERLEEEKRKLQDEADDITQRLNEESESRRKMSDKLSHERHTNQKEKECTQGLIEDLRKQLEHLQLFKLETEARRGRSSSNGLQEYNTHMRENELEQEIRRLKQDNRSLKEQNDELNGQIINLSIQGAKSLFTESLSESLAAEINNVSRAELMEAIHKQEEINFRLQDYIDRIIVAIMESNPSILEVK
What is the function of this protein?
Acts as a regulator of endocytic traffic by participating in membrane delivery.  Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis.  Also required for the structural integrity of the endosomal recycling compartment during interphase.  May act as an adapter protein linking the dynein motor complex to various cargos.
What are the official names of this protein?
Rab11 family-interacting protein 3, FIP3-Rab11, Rab11-FIP3.
What are the subcellular locations of this protein?
Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission.
Protein: PSR1_PHYSO
Sequence: MRLTYVLLVAVTTLLVSCDATKPSTEATAVSKRLLRFVEAADEEERRIDFSPEKLRKMLGDETYRLKKFGKWDSDGHTFDGLKHYLLLSDSSMVKLRNMYKAWLEQ
What is the function of this protein?
Secreted effector that possesses RNA silencing suppression activity by inhibiting the biogenesis of small RNAs in the host plant to promote enhanced susceptibility of host to the pathogen during infection (PubMed:23377181, PubMed:25902521, PubMed:30963588).  Interferes with secondary siRNA production by associating with host nuclear protein PINP1 that acts as a regulator of the accumulation of both microRNAs and endogenous small interfering RNAs (PubMed:25902521).
What are the official names of this protein?
RxLR effector protein PSR1, Avirulence homolog protein 18, Suppressor of RNA silencing protein 1.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Note=The nuclear localization is required for this interaction.
Protein: MNMG_WOLPP
Sequence: MHKYDVVVVGGGHAGCEAATAAARLGASTLLITHKISTIGEMSCNPAIGGVAKGVVVREVDALDGIMGRAIDRASIHSVVLNGSRGAAVWGPRAQADRKLYKKAIQEIILNYNNLTVKEESVDDFLIESDSNGESYIKAVITDSGERILTSRVVLTTGTFLRGVIHIGEQTTPSGRIGDKPAIELANTLKKYDFKLGRLRTGTPPRLDRGTINWSVLQEQVGDNPPTPFSYLTEKINQPQVSCFITHTNEHTHRVIRENLHRSASSYLDNVIAPRYCPSIETKVKKFAEKNNHQIFLEPEGIDDNTIYPNGISNSLPIEVQYEMIKSIKGLENAEILRPGYAVEYDYIDPRELFHTLETKKVKGLYFAGQINGTTGYEEAAGQGIIAGINAALSLSQKSFVLHRTDSYIGVMIDDLVTKGITEPYRLFTSRAEYRLAIRSDNADRRLTQKGYDISLVSHERYSVLQGKLKSIKQLEEKLESLTITPEQLRSYGIKISYDGIRKTALDLLGYPNIDWNKLREIWPELNMGSSVSYLHNAKAPLPVIQVADTGIQYLNDDGMDAVDTEKNVDSSVMCWNNTITDSIAKNEIYEAVAIEAKYKPYLVRQEADMKFLQEEVNTQIPTNFNYSQIKGLSTEVIEKLQSIKPATIGIAKQIQGITPAAIVSILVYLRNKKTKIAANSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CXA1_URSAM
Sequence: MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLATGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
What is the function of this protein?
Gap junction protein that acts as a regulator of bladder capacity.  A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.  Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.  May play a role in cell growth inhibition through the regulation of NOV expression and localization.  Plays an essential role in gap junction communication in the ventricles (By similarity).
What are the official names of this protein?
Gap junction alpha-1 protein, Connexin-43, Cx43.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and proper localization at ICD is dependent on TMEM65.
Protein: RS19_XANOP
Sequence: MARSLKKGPFVDHHLAKKVESAAGSKKPIKTWSRRSMILPEMVGITIAVHNGKNHIPVLVNENMVGHKLGEFAVTRTFKGHGGDKKSSR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: KDSB_BRUSU
Sequence: MLQTMKTLTLIPTRLGSTRLPNKPLADICGKPMIVHVADRAAAAKLGRTVIATDSEEIFKVVAAHGHEAIMTRGDHESGSDRIYEALAKLDPSGEIDAVVNVQGDLPTIDPDTIRRALLPLEDGPADIATLGVEITVEEEKTNPNVVKIVGSPLAGNRRLRALYFTRATAPYGEGPLYHHIGLYAYRRSALERFVKLGPSPLEKREKLEQLRALEAGMRIDVEIVKTVPLGVDTQADLDRARTFCSQAGTI
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H2AZ_NEUCR
Sequence: MAGGKGKSSGGKSSGGKTSGVEGPKKQQSHSARAGLQFPCGRVKRFLKQNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKKAKAQEA
What is the function of this protein?
Variant histone H2A which can replace H2A in some nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received.  Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins.  Required for the RNA polymerase II and spt15/TBP recruitment to the target genes.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Histone H2A.Z.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: IL15_MOUSE
Sequence: MKILKPYMRNTSISCYLCFLLNSHFLTEAGIHVFILGCVSVGLPKTEANWIDVRYDLEKIESLIQSIHIDTTLYTDSDFHPSCKVTAMNCFLLELQVILHEYSNMTLNETVRNVLYLANSTLSSNKNVAESGCKECEELEEKTFTEFLQSFIRIVQMFINTS
What is the function of this protein?
Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:8757333, PubMed:11466332).  Stimulates the proliferation and activation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8757333).  In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (By similarity).  Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits.  Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5.  In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (PubMed:10882748, PubMed:19632221).
What are the official names of this protein?
Interleukin-15, IL-15.
What is the protein family that this protein belongs to?
Belongs to the IL-15/IL-21 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SSRP_SALAI
Sequence: MPREKGRKVVASNRKARHDYSILDTYEAGMALTGTEVKSLRAGRASLVDAFAQERNGELYLHGMHIPEYVQGTWTNHEPRRTRKLLLNRTEIDRLIGKTRESGLTLVPLQVYFSDGWAKVEIGVAKGKKAYDKRQDLAKRDAQREMARAAGRRSKGMDD
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RBSA_LACLS
Sequence: MKIEMKNISKSFGTNKVLEAIDLPINSGEVHALMGENGAGKSTLMNILTGLFPASGGEIEIDKEDKTFKNPQEAEGFGISFIHQEMNTWPDLTVLENLFLGREIKNKFGVLDTKAMRKKATFAFEQLGVTIDLDKEIGNLSVGQQQMVEIAKSFLSDLKILIMDEPTAALTERETERLFSVIAGLKAQGVGIIYISHRMEEIFKITDCVTVMRDGLVIDTKKTKETNVDELVRKMVGRSITDYYPQKNAEIREIVFEAENLSTADFKNISFSVRSGEILGFAGLMGAGRTEVMRAIFGIDKLKSGTIKINGKSLTINNPAQAIKAGIGFLTEDRKDEGLVLDFSIKDNITLPSTKDFIHHGLFDDKTATTFVKQLSERLNVKATDEEQMVGSLSGGNQQKVVLAKWIGIAPKVLILDEPTRGVDVGAKREIYQLMNELAERGVPIIMISSDLPEILGVADRIAVMHEGKIAGFLNKKEATQENVMQLATGGK
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GSTP2_MOUSE
Sequence: MPPYTIVYFPSPGRCEAMRMLLADQGQSWKEEVVTIDTWMQGLLKPTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKNQREAAQVDMVNDGVEDLRGKYGTMIYRNYENGKNDYVKALPGHLKPFETLLSQNQGGKAFIVGDQISFADYNLLDLLLIHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPEHVNRPINGNGKQ
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  Cannot metabolize 1-chloro-2,4-dinitrobenzene.
What are the official names of this protein?
Glutathione S-transferase P 2, Gst P2, GST YF-YF, GST class-pi, GST-piA.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Pi family.
Protein: RIMP_PELPB
Sequence: MQERINNCVTQVLAESAGTRGEGAYLIDIKVKGKGSGRKIEILMDADDGIRIHQCAYISRRVRERIEGDDDLLELVGENFDLMVSSPGLGEPIIIPRQYIRHVGKLLQVTYADSNGDPVELVGHLQEVSLLDEHGAKIVIMPEQKKKKGQQPKTEAVILYLNQVIRAIPEAEL
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.