PharMolix/UniProtQA huggingface dataset:
Protein: MATRX_MMVR
Sequence: MDAPINPSSPTRSSYETALERQWLIKDEPSHHVDLGCHFTLEIKAFSPKMIELLETGSLTLGSVYQGLYNLIKDKDCKGLELDRDTTHGNKLHVLAAAFLCVLRKYENQVRFYNVKTKDSLTGEIQYMSRVHIGDDNLGLFDPDTYRMIGGSFPEGIYRLNLRTQLTPRGEDDGLEIIMGTILTVPVRGPADRQPLGVLMDRQLRQFPVGTNPWSSLGEAKPKGRSLSLLRGILM
What is the function of this protein?
Plays a major role in assembly and budding of virion.  Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form.  Inhibits viral transcription and stimulates replication (By similarity).
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the nucleorhabdovirus type-2 matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein.
Protein: ARSC1_CORGL
Sequence: MNNQPSVLFVCVGNGGKSQMAAALAKKHAGDALKVYSAGTKPGTKLNQQSLDSIAEVGADMSQGFPKGIDQELIKRVDRVVILGAEAQLEMPIDANGILQRWVTDEPSERGIEGMERMRLVRDDIDARVQNLVAELTQNA
What is the function of this protein?
Involved in defense against toxic arsenate.  Involved in the mycothiol/myoredoxin redox pathway which uses a mycothioltransferase mechanism; facilitates adduct formation between arsenate and mycothiol.
What are the official names of this protein?
Arsenate-mycothiol transferase ArsC1, Mycothiol-dependent arsenate reductase ArsC1.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_CLOB1
Sequence: MNYNKKSIEDIDVKGKKVLVRCDFNVPLNEGKITDENRLVGALPTIKYLMEKGAKIILCSHMGKPKGEPKKELSLLPVAKRLSEMLNKEVIFADDDNVVGENAKKAVEDMKDGDVVLLQNTRYRKEETKNEEVFSKELASLADVFVNDAFGTAHRAHCSTVGVTNYLKEAACGYLIQKELKFLGNAVEKPERPFVAILGGAKVSDKINVINNLLDKVDTLIIGGGMGYTFLKAQGYTIGNSLVEEDKVEYSKEMIDKAKEKGVNLLLPIDNVVADKFDKDASPVITEDQNIGEGYMGLDIGPKTAKIYSDAIKSAKTVVWNGPMGVFEFKSFANGTIEVAKAMADSDAVTIIGGGDSAAAVNILGFGDKMTHISTGGGASLEFLEGKELPGIAALNDK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_PARUW
Sequence: MINQANKTAKLRVKRAVRVRKHLRGTGLKPRLCVVKSNSHIQAQLIDDETGTTLGGTATFAKEYRNTEFCKKNKASARKLGEQIAEIAKSKNIKEVVFDRGPFKYHGILAELANAARAGGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ICP27_EBVA8
Sequence: MVPSQRLSRTSSISSNEDPAESHILELEAVSDTNTDCDMDPMEGSEEHSTDGEISSSEEEDEDPTPAHTIPARPSSVVITPTSASFVIPRKKWDLQDKTVTLHRSPLCRDEDEKEETGNSSYTRGHKRRRGEVHGCTDESYGKRRHLPPGARAPRAPRAPRVPRAPRSPRAPRSNRATRGPRSESRGAGRSTRKQARQERSQRPLPNKPWFDMSLVKPVSKITFVTLPSPLASLTLEPIQDPFLQSMLAVAAHPEIGAWQKVQPRHELRRSYKTLREFFTKSTNKDTWLDARMQAIQNAGLCTLVAMLEETIFWLQEITYHGDLPLAPAEDILLACAMSLSKVILTKLKELAPCFLPNTRDYNFVKQLFYITCATARQNKVVETLSSSYVKQPLCLLAAYAAVAPAYINANCRRRHDEVEFLGHYIKNYNPGTLSSLLTEAVETHTRDCRSASCSRLVRAILSPGTGSLGLFFVPGLNQ
What is the function of this protein?
Promotes the nuclear export of a subset of early and late viral mRNAs by interacting with mRNAs and cellular export proteins.  Additionally may prevent the establishment of cellular antiviral state, by acting as an alternative splicing factor for cellular RNAs such as STAT1, resulting in a STAT1 mRNA incapable of producing the STAT1alpha isoform.
What are the official names of this protein?
mRNA export factor ICP27 homolog, Mta, ORF57 protein homolog, Protein EB2, Protein SM.
What is the protein family that this protein belongs to?
Belongs to the HHV-1 ICP27 protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=shuttles between the nucleus and the cytoplasm.
Protein: ARL11_HUMAN
Sequence: MGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVLANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGEGLPEALQSLWSLLKSRSCMCLQARAHGAERGDSKRS
What is the function of this protein?
May play a role in apoptosis.  May act as a tumor suppressor.
What are the official names of this protein?
ADP-ribosylation factor-like protein 11, ADP-ribosylation factor-like tumor suppressor protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
Protein: HIS3_ARCFU
Sequence: MELQFDEKGLIPVITQDVKTKEVLMLAYANEEAIKLTLKTGFAHYWSRSRKKLWKKGETSGNVQRVVEIRYDCDCDALLYLVEQKGNACHTGNYSCFYRRLEGDEVRC
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_YERPS
Sequence: MNLHEYQAKQLFARYGMPAPTGYACTTPREAEEAASKIGAGPWVVKCQVHAGGRGKAGGVKLVNSKEDIRAFAEQWLGKKLVTYQTDANGQPVHQILVEAATDIDKELYLGAVIDRSSRRVVFMASTEGGVEIEKVAEETPELIHKIALDPLTGPQPYQGRELAFKLGLTGKQVGQFTKIFMGLATLFLERDLAMVEINPLVVTKQGDLICLDGKLGADGNALFRQPELREMRDPSQEDAREAHAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDKVKAVFVNIFGGIVRCDLIADGIIGAVEEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAATSLTDAAQQVVAAVGAK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: THIO_HUMAN
Sequence: MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
What is the function of this protein?
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
What are the official names of this protein?
Thioredoxin, Trx, ATL-derived factor, ADF, Surface-associated sulphydryl protein, SASP.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: HSLV_TOLAT
Sequence: MTTIVSVRRNGQVVIGGDGQVSLGNTVMKGNARKVHRLYNGKVLAGFAGGTADAFTLLERFEAKLQAHQGNLERAAVALAKEWRTDRALRRLEALLAVADAQRSFIITGNGDVVQPENDLIAIGSGGAFAQSAARALLENTELSAEEIVKKALTIAGDICVFTNSFHTIEVLEYPTVTPV
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADMB_ARTOC
Sequence: MKALSCLLAVIATAGSLFQHVDARSHARDRLNNISRVERPVIHTPSHRVHAHSHFDLTFDLYPRSSRIKLQLEPNHDVLSHDARVAFLDGEGNVDRMERIERRDHRVFKGWAWVQRKSGSWERVGWARVMMQRDGEDPLFEGVFTVMHDHHQIIPKTKYVHKRHPHDPPLDATPGEYMLLFRGSDIRTQTHDTVERSITSSPSCDADTLAYGTQSDFMFPPLPQENNTNLWGSLMTSIGRRQNSDTVGTVPGSQNLRDTIGNTDGCPNTRRVALIGVVADCTYTSTFASEMDAKTDIISVVNAASVVYEHTFNISLTLGEVNILPKNCPATASSATPFNQMCGERVGDESFTLADRLNTFSAWRGKKSDDFAFWTLMTDCTTENQVGLAWAAQLCVKGVQGDSNTRNASSQAVSGANVVSKTDNTWQVFAHEAGHIFGAVHDCDSALCQDPSNPDNSRCCPSTATTCDAGGKFMMNPTSGSQITAFSPCSVGQICSRMAKHSILTNCLTTNRGVDTISGQQCGNGIVEDGEDCDCGGDESCKGNKCCDPKTCKYTSGSQCDDANEECCRDCKFASSSTICRLSSGPCDPEEKCTGNSGDCPRDTHSKNGETCGTNLQCASGQCTSRDLQCQMHLGSQVAGSRTVAFDSYGCQVACKDPYRPDVRYEGSLTFLDGTPCGGGGTCENGQCTGSTFGNEVSDWVSRHKPIVIGVAVGVGCLLLLAILSCICGRSKKRRPRNRKMAPINMRPMPPVYNGWTGPPPNAESPGGHPQYNHVPPPINAPPPAYPGRMPSTRYA
What is the function of this protein?
Probable zinc protease.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein B, ADAM B.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: UPP_LACDA
Sequence: MGKFTVLNHPLIQHKLTIIRRKETGSNEFRRIVGEIAGLMTYEITRDLPLQDVEIETPMGKTVQKELAGKKLTIVPILRAGMGMVNGVLEMIPSAKVGVVGMYRDEETLKPVEYFFKVPKDVTERECLVVDPMLATGGSANLAIEALKKRGVTDIKLAVLVAAPEGVKAVQDEHPDVDIYAAALDDKLLPNGYIFPGLGDAGDRIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: TM140_RAT
Sequence: MAISRVWRNRLSFMAIMILVAMVLSLMSYALLWKAGNLTDVPNLRIGFYNFCLWKEDIGSLECYNFPELGVLGIPQVGLALARLGVYGALVLAVFVPLPLLLAQCNSDEGEWRLAVGFLGASSVLLAGGLSLFLFLVWKWLRLSFLGPGFLSLCLAQALLIILLMAMVMFPPRDKKDKNHWENC
What are the official names of this protein?
Transmembrane protein 140.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYE_THEFY
Sequence: MTDKAIRTRFAPSPTGMFHVGGARSALFNWALALQQPEGKFVLRIEDTDAARNRPEWTEGILRALSALGIDERDPHFEGPYFQSAYADKHREVAEELYRKGRAYYCDCTREQIQERRGNPHLGYDGYCRDRGLEPGPGRALRFRVPEGGPTVVDDKIRGRVEFDHSAIEDFVIARSDGSPLFVLANVVDDVEMAITHVVRGEEHLSNTPKQQLLWEALGQTPPVWAHLPVIVNEKRQKLSKRRDKVALEDYLAEGYLPEAMVNYLMLLGWGPGDDREIMPFSEMVPLFRLEDVNSSSAFFDEKKLRAFNGEYIRALDTTEFVERCAPWLGSEKAPWPAENFDAQVFEAVAPLAQTRISVLSEIVSYVDFLFLDRPVEDEKSWAKAMKPGVGEEMLTAALERFSDPNLEWRAEPLKAALEEVAAAQGLKLGKAQAPVRVAVTGRTVGLPLFESLELLGRSRVQERLRAALEKLKAAGE
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUG60_SCHPO
Sequence: MDSHVLAFPIPDPSTPPPEEASLYASKCDYYESDIYSQIRRLTEEKCIETEKELPVNIKLHVKHKGMSISSSRNELVVTVSGNYKNVYTAKIKILQAIPKILISKLVLEEPLENLLFDEDGYVYEDTMKHLDKITEITGAKIYIMHRSMCHDIDFQLRTDSGFSNRLNEQQSFYQRHLESTRHEFSCQKNAENSFFIVFYGDYCSVEHARIRVLALMDEIRGLSVVAIATSVSFQPILVGKAFSSTAGMKATESINIYTLPFCSDSIPRLQTLPALNSSKIIITGEEEKLQRLEEAFYYAEEHLKLFTHVTEISFVKLFEFLAYEMDELRLIMEENSSFIRFPEYFKEGGETSPENSKVKIYSSSIANSEKTALRLAKLASKYVQGKTQFGVEDNEDFLRVAGSWRRASTIEKGVSSSELSSIVSSTGSIVETNGIGEKMSFSPLKKLSIPPTEFVAQIAIICMASGVEMLLKTNGIEYFGQENTVPIAMDKASKIFYKFGQSQWHQILLEAPTKDQDFISGKKNGKLDKVKQQCRFNLKNGDILFCPQSTSIFTVDIYSDELERVIKGMNTMLLEFPAEMHFYVPEEIHKKLIGFRGEQIQRVTKLYNSYIEFSTTPFDCYGHNVLIRTPSKFSENLWAVRSLFIKTAEGLGYDIPKYLFAN
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 60 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: AUTS2_MOUSE
Sequence: MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGAGRTRAPSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVAVKPQERAEKRQTPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQHLGKRKKMPKGLRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVLVNKDPELGVGALPEHNQDAGPIVPKISGLERSQEKSQDCCKEPVFEPVVLKDPHPQLPQLPSQAQAEPQLQIPSPGPDLVPRTEAPPQFPPPSTQPAQGPPEAQLQPAPLPQVQQRPPRPQSPSHLLQQTLPPVQSHPSSQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSPAPPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYENPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR
What is the function of this protein?
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.  The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B.  As a consequence, the complex mediates transcriptional activation (By similarity).  In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development.  Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (PubMed:25533347).
What are the official names of this protein?
Autism susceptibility gene 2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the AUTS2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton. Cell projection, growth cone. Note=Detected both in cytoplasm and nucleus (PubMed:25533347). Colocalizes with RAC1 at actin-rich growth cones (PubMed:25533347). Detected on the promoter region of actively transcribed genes (PubMed:25519132).
Protein: HEM3_PHOLL
Sequence: MSTKTIRIATRQSPLAMWQALYVQQKLQQCHPDLEVQLVPMVTQGDVILDTPLAKIGGKGLFVKELELALLEGRADIAVHSMKDVPISFPEGLGLVTICERDDPRDAFVSVKYHSLDELPTGSIVGTSSLRRQCQLRELRPDLIVRDLRGNVGTRLNKLDNGHYDAIILAVAGLKRLKLHERIRTPLTAEQSLPAVGQGAVGIECRLDDQQTQTLLAPLNHYDTEVCVLAERAMNTRLEGGCQVPIGSYAIWQDGKIWLRALVGAPDGSVIIRGERTALPKDACQAGVELAEELLERGAREILTQVYRGNPST
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: TRMB_RHOPB
Sequence: MPDPRDDDEAATAMPERAFFGRRKGHKLRSHQADLIAELLPRLSFDLGAPAPARLETLFASGIAEVRLEIGFGGGEHLIAEALAHPTTGFIGCEPYVNGMAKILAQIEARELGNIRLFAGDAAELLAWAPPASLARVDLIHPDPWPKRRHWKRRFVQDTSVAAMARVLHEDGEFRFVSDIDDYCAWTLAHLLRSKEFCWTAERACDWQLPFAGYTMTRYGRKAEREGRRAAYLHFRRAAAAPNDRAKAGEL
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: NADE_STRMU
Sequence: MSLQEDIITQLGVKPKIDAQEEIRKSIDFLKAYMKKHGFLKSYVLGISGGQDSSLAGRLAQLAIEELRHETGDNGYKFIAIRLPYGVQADEDDAQRALNFIQPDVSLAINIKPAVDGEVAALAEAGVQVSDFNKGNIKARQRMISQYAVAGENGGAVIGTDHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLAELGADKALYEKIPTADLEENKPGIADEVALGVTYNDIDDYLEGKQVSPAAQKIIENWWNKTEHKRHLPISIFDDFWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: CRG4_XENLA
Sequence: IFFYEERNFQGRCYECSSECSDLSSYFNRCNSIRVESGNWILYEQPSYRGHQYYLWKGEYPDFQRWMGFNDYIKSCRFIPHPHSQYKMRIYERGDFQGQMMEFFDDCPNTYDRFRFRDIHSCNVSDGHWMFYEEPNYKGRQYYLRPGEYRRFSDWGASSARIGSFRRVHHMV
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin-4, Gamma-4-CRY, Gamma-crystallin IV.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: LPXB2_LEGPL
Sequence: MIKKRQTRIAMIAGEMSGDLLGAGVIRELKKHLKNVEFIGVGGPQMLEEGFQSLANMSELSVMGISDVLRRYPQLYFIRERLLKEWTINPPDVFIGIDYPDFNLSVETRLKRQNVKTVHLVSPKVWAWRQKRVYLIKKAVDLVLTLFPFEESFYQQYDVPAQFVGHPLADLIEINPNNADLRKKYNYKPDDTILAVLPGSRIGEIKYIGPLFLEVMQRIAVEMPHVHFIVPIACQELYPVFFKQFQARYSHLKIQIIQGNAREAMAISDVVLTKSGTATLEAMLLKRPMVVAFKWSKFTHAIIAPQVKIPYVALPNLLANKKLVPEFVQEKATANSITESVLNLLACPSQSNLNKQFTAIHHTLRQNANEKAALSILKILETSSA
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase 2.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: TRPB_PSEPK
Sequence: MTQSQYRPGPDANGLFGSFGGRYVAETLMPLVLDLAREYEAAKADPKFLEELAYFQRDYIGRPNPLYFAERLTEHCGGAKIFFKREELNHTGAHKVNNCIGQVLLAKRMGKKRLIAETGAGMHGVATATVAARFGLPCVIYMGATDIERQQANVFRMKLLGAEIVPVTAGTGTLKDAMNEALRDWVTNVEDTFYLIGTVAGPHPYPAMVRDFQSIIGKETRAQLQEKEGRLPDSLVACVGGGSNAMGLFHEFLEEPSVQIIGVEAGGHGVHTDKHAASLNGGVPGVLHGNRTYLLQDQDGQITDAHSISAGLDYPGIGPEHAYLHEVKRVEYVSITDDEALDAFHATCRLEGIIPALESSHALAEAIKRAPKLPKDHLMVVCLSGRGDKDMQTVMNHMAAQEKQA
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: 143BB_DANRE
Sequence: MDKSDLVQKAKLAEQAERYDDMAAAMKAVTEGGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGNEKKQQMAREYREKIETELQDICSDVLGLLEKYLIANASQAESKVFYLKMKGDYYRYLSEVASGDSKATTVENSQKAYQDAFDISKKDMQPTHPIRLGLALNFSVFYYEILNSPENACQLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSENQGEEAGENEN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner (By similarity).
What are the official names of this protein?
14-3-3 protein beta/alpha-B.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEP1_EBVA8
Sequence: MASGKHHQPGGTRSLTMQKVSLRVTPRLVLEVNRHNAICVATNVPEFYNARGDLNIRDLRAHVKARMISSQFCGYVLVSLLDSEDQVDHLNIFPHVFSERMILYKPNNVNLMEMCALLSMIENAKSPSIGLCREVLGRLTLLHSKCNNLDSLFLYNGARTLLSTLVKYHDLEEGAATPGPWNEGLSLFKLHKELKRAPSEARDLMQSLFLTSGKMGCLARSPKDYCADLNKEEDANSGFTFNLFYQDSLLTKHFQCQTVLQTLRRKCLGSDTVSKIIP
What is the function of this protein?
Plays a critical role in cytoplasmic virus egress.  Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm.
What are the official names of this protein?
Cytoplasmic envelopment protein 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 1 family.
What are the subcellular locations of this protein?
Virion. Virion tegument. Host cytoplasm. Host Golgi apparatus.
Protein: DDIT4_XENTR
Sequence: MPARWDTFSALSVPPPILEEEPQSQFWGEDCADVSQRCSSLPSSDCESLTSSNSYSECDLDAWDEISLPDSELLNDPEGEQLCPSLLKLIKRCLTKAKINSLRCSRLLIPDELLCNLGQELLHLAYSEPCGLRGALIDLCVEHGKDCHSVAQITVDQAVVPTFQLTVLLRLDSRLWPRIQGLFSTKPVPGSGQSLKLSPGFKVLKKKLYSSEELIIEEC
What is the function of this protein?
Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1).  Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb.  Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity.  Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (By similarity).
What are the official names of this protein?
DNA damage-inducible transcript 4 protein, Protein regulated in development and DNA damage response 1, REDD-1.
What is the protein family that this protein belongs to?
Belongs to the DDIT4 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: VP26C_PONAB
Sequence: MGTALDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSNIEMVKPGKFPSGKTEIPFEFPLHVKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHSAPQKGKFSPSPVHFTITPETLQNARERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTNFKVEFEVNIVVLLHPDHLITENFPLKLCRI
What is the function of this protein?
Acts as component of the retriever complex.  The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1).  The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes.  In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 26C, Down syndrome critical region protein 3 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS26 family.
What are the subcellular locations of this protein?
Endosome.
Protein: GLK_CROS8
Sequence: MTKYALVGDVGGTNARLALCDVDSGEILKAKTYSGLDYPSLEAVVRVYLEEHNATVTDGCIAIACPITGDWVAMTNHVWAFSVAEMKKNLGFDHLEIINDFTAVSMAIPMLKTDHLIQFGGGEPQPNKPIAVYGAGTGLGVAHLVHVDKRWVSLPGEGGHVDFAPNSEEEAIILEQLRAEVGHVSAERVLSGPGLVNLYRAIVKADGRLPDNLRPKDITERALDDSCTDCRRALSLFCVIMGRFGGNLALTLGTFGGVYIAGGIVPRFLDFFTSSGFRGGFEDKGRFKSYVQDIPVYLIVHDQPGLLGAGAHLRQTLGQIL
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXG3_SCHPO
Sequence: MGLNKQDLYIYRKQYGVNLGAWFCAERWINDFLFTGEGSSELEAVSGNVKAHGIDKARENFEAHWKSWIGIEDFSYMKQHLVNSVRIPLGYWSLGNDELVKGTPFEPYAEVYRNSLHILCEKIQEAGSLSIGVLLDFHGVYGGGNCDGHSGTSSGKAEFYEKQEYQDRTVEAVKFLSSKIGQFENVIGIQVINEPIWGQYDVLANFYQKARSVVPSYLPVYIGDGWDKDHWVNWVNDHESEGFYVVDHHSYFCFGGELCHAPPKLITRRLDTGEEYGKTKLSNIVIGEWSCTLSQESWSQTKLHDKRRRDFGEAQLNQYLNYCGGCFFWTYKFLHGKGGDWDFRSVVEDKVINYPPPPPTENKAMPALLEQSRDQNFGGHCYYWDQKQHDHPYEHDLYVKGWNQAWEDYIEFLQHGAMIGFPRAWTQKRMTSISSASAWEYRDGMNAAWLHLERMGFLNPFRHP
What are the official names of this protein?
Glucan 1,3-beta-glucosidase 3, Exo-1,3-beta-glucanase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.