PharMolix/UniProtQA huggingface dataset:
Protein: TX1A_TLIAL
Sequence: MNTIQVIIFAVVLVLTVTVGQADEDSAETSLLRKLKEAEASLFGQHLEESQHSREKRCLGENVPCDKDRPNCCSRYECLEPTGYGWWYASYYCYKKRSG
What is the function of this protein?
Insecticidal toxin that shows strong lethal effects on American cockroaches (P. americana) and common mealbeetle (T. molitor) (PubMed:25329070).  Possibly acts by blocking ion channel currents (Probable).  Also shows significant analgesic effects in mice models of pain including abdominal writhing induced by acetic acid and formalin-induced paw licking tests (PubMed:25329070).  In addition, exerts marked inhibition of proliferation of some human tumor cell lines including C8166, Molt-4, A-549, BIU-87, T24, and Calu-6 (PubMed:25329070).
What are the official names of this protein?
U1-theraphotoxin-Tal1a, U1-TRTX-Tal1a, Brachyin.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 14 (magi-1) family. 08 (Ltx-4) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SAER_STAA8
Sequence: MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGYDIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMKKYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
What is the function of this protein?
Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion.  Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes.  SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (Hla, Hlb), Coa, DNase, Spa and cell wall-associated proteins (Emp, Eap, FnbA).  Acts probably downstream of the Agr system in the regulatory cascade of virulence factors.
What are the official names of this protein?
Response regulator SaeR, Staphylococcus exoprotein expression protein R.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_HALH5
Sequence: MTKLWGGRFTKTAEAWVDEFGASIGFDQQLVEEDIEGSLAHVTMLEKSGILANEEVEQIKKGLHILLEKAKKGELNYSVANEDIHLNIEKLLIDEIGPVGGKLHTGRSRNDQVATDMHLYLRKQTKEILQLVKNVQAALVEQAKQHVETLIPGYTHLQRAQPISFAHHLLAYFWMLERDYGRYEDSLKRLNVSPLGAGALAGTTFPIDREYTAELLGFDGIYENSLDAVSDRDFIVEFLSASSLLMTHLSRLCEELILWSSQEFQFVEMDDAFATGSSIMPQKKNPDMAELIRGKTGRVYGSLFSLLTVLKGLPLAYNKDMQEDKEGMFDAVKTVKGSLAIFAGMIQTMKVKEETMTKAVHQDFSNATELADYLATKGMPFREAHEVVGKLVLLCIQKGIYLLDLPLSDYKAASDLFDEDIYDVLQPKTVVARRTSAGGTGFTEVKKAIAKAEKILAN
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Protein: MYOG_PIG
Sequence: MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERTELSLSPEARVPLEDKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPGVPSECSSHSASCSPEWGSALEFGPNPGDHLLTADPTDAHNLHSLTSIVDSITVEDVAVAFPDETMPN
What is the function of this protein?
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy.  Essential for the development of functional embryonic skeletal fiber muscle differentiation.  However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity.  Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation.  During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1.  Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis.  Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters.  Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression.  Binds to the E-box containing (E1) promoter region of the miR-20a gene.  Plays also a role in preventing reversal of muscle cell differentiation.  Contributes to the atrophy-related gene expression in adult denervated muscles.  Induces fibroblasts to differentiate into myoblasts (By similarity).
What are the official names of this protein?
Myogenin.
What are the subcellular locations of this protein?
Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.
Protein: MGAT2_MOUSE
Sequence: MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKSDALGPPLLDAEPVRGAGHLAVSVGIRRVSNESAAPLVPAVPRPEVDNLTLRYRSLVYQLNFDQMLRNVGNDGTWSPGELVLVVQVHNRPEYLRLLIDSLRKAQGIQEVLVIFSHDFWSAEINSLISRVDFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLKKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKVLQDYTGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPGCDVLSLGTYTTIRSFYGIADKVDVKTWKSTEHNMGLALTRDAYQKLIECTDTFCTYDDYNWDWTLQYLTLACLPKIWKVLVPQAPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNSNKQYLFPETLVIGEKFPMAAISPPRKNGGWGDIRDHELCKSYRRLQ
What is the function of this protein?
Plays an essential role in protein N-glycosylation.  Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.
What are the official names of this protein?
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Beta-1,2-N-acetylglucosaminyltransferase II, GlcNAc-T II, GNT-II, Mannoside acetylglucosaminyltransferase 2, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 16 (GT16) protein family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: NRK1_HUMAN
Sequence: MKTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETDKNGFLQYDVLEALNMEKMMSAISCWMESARHSVVSTDQESAEEIPILIIEGFLLFNYKPLDTIWNRSYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVWPMYLKYRQEMQDITWEVVYLDGTKSEEDLFLQVYEDLIQELAKQKCLQVTA
What is the function of this protein?
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).  The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.
What are the official names of this protein?
Nicotinamide riboside kinase 1, NRK 1, NmR-K 1, Nicotinic acid riboside kinase 1, Ribosylnicotinamide kinase 1, RNK 1, Ribosylnicotinic acid kinase 1.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family. NRK subfamily.
Protein: YF3A_SCHPO
Sequence: MQLNRKQLKNLHNYKYSAIDNSLLSKYILKPYWWNQLLKVIPMSMAPNLITLIGLGFVVINILTMLVYKYHYEMDAFPSWVYASWAIGLFLYQSFDAIDGSQARRTGTSSPLGQLFDHGVDAINTSFEVLLTIELLQLDMFSSILTQFASLLYFYISTWEEYHTGTLYLSYFSGPVEGIVMVIGLFALTAIKGDSFWLKLHPTPESWGFVRSFLPYYTYGSCLYNFMAFALLLNVLQSLRNALQAVQKNNGSVIKALSGILPYFLQWMAVFSLYAKYPAFFEHHFLTIFCLNAFIFAYSVGVVIVSHITESPFPYWNVLILPFLVDAVDAYTFGVLKNVQTEYFFCYVGICIGVYGNFVAHVIAMITEEYGIKCLTIPSKPESKKN
What are the official names of this protein?
Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ORS1_ARATH
Sequence: MRVHDQRLRFDVTPKPMGLNGSSLITARSVALLLFLSLLLLILPPFLPPLPPPPATLLLLPLLLMILLIFLAFSPSNEPSLAVEPLDP
What is the function of this protein?
Together with ARGOS and ARL, regulates organ growth and final organ size.  Promotes both cell expansion and proliferation-dependent organ growth, in an ANT-dependent manner.
What are the official names of this protein?
Protein ORGAN SIZE RELATED 1.
What is the protein family that this protein belongs to?
Belongs to the plant organ size related (OSR) protein family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Nucleus. Cytoplasm.
Protein: HSLO_LEVBA
Sequence: MADYLVKSLIDGGMFRAYVVDATETVAEAQQRHDTWSAATAALGRTLIGTMLLSTSLLKGDEKLTVKVNGHGPVGAIVVDGNANGTVKGYLQYPHTSLPLNEKHKIDVKKAVGVNGMLTVTKDQGLGQPYTGQVPLVSGELGEDFTYYLAKSEQIPSAVGVSVFVQPNNTVKVAGGFLIQVMPGASDEAIARLEQRIKEMPMVSELLLAGQTPEEILALLFKEEKIKIVQKMPVGFKCDCSKDRFAQSLASIQPAALQEMIDEDHGAEAVCHFCGTKYQFSEDDLRAILTEAQAK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_RICAE
Sequence: MIVIFLGPPGAGKGTQGKKIAKKINLPHIAIGDIFRTIIKTSTSEAELINNYVKQGELIPNEIVNQVIKNFLLSSEYKNGYILDGYPRNLEQAKFFESFIKEKIKIIYFDVSDELLIKRILGRYSCKNCGKIYNRYFLQPKTDNVCDVCGSSTFDYRKDDNEEVIKKRIEVYKTETYPLIDYYKNSGNFYIVNGSKSEQEIEIDIQKILKIN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNB_SALPC
Sequence: MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVPWWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSKLDNTAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLAYDNVSDWLENNGTWQPDNEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCAARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGTNTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDALVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPAA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIR1_KLULA
Sequence: MKLLKLPWLQHREEHKSYEVYTCDVSPDSQRLATGGLDGKIRIWSIPDILKFASNPNASTDKDILMKPLSTMSRHAGSVTTVKFSPDGKYLASGSDDRILLIWELEGGTTQPMFGAESTDIEHWNVRRRLVAHDNDIQDICWAPDSSIMVSVGLDRAIIIWNGSTFEKVKRFDVHQSHVKGVVFDPANKYFATASDDRTIKMFRYHKTGETSFSVEHVITEPFKGSPLTTYFRRLSWSPDGQHIAAPNAMNGPVSTVAIIERGTWESPVSLVGHDQPTEVASFNPRIFKRQKDDSTTDTIDGKKTGISDEVDCIVASSGQDKTLAVWSTSKARPLIVAQDICGKSITDMSWTPDGKILFITSLDSSIVVLTFEDNEFGEAIPLEQNIEYLHRYGVDKDSLVFPETVEQLILEDQAKNLKKSNVDMNLLENRLGKPGTIAEPNILQVRSKKRAQLTGTGNHTDNNTTSKAEPPHVNILQVKRKNKVTGVTEVLHDTVVKNGKKRVAPTLITMGHSPDKSRKRVILSTAQSLNNTVQPTTKPAPEEKSTLAKLQSTKLSKPSFSIPRLGIHTLIMGFKERTRENFINQGSTDSTVDESNVNIDEGPQQLEQNSAEEHLLTLNSKTTLEKIWRDEPNTRYLEFNSILPDADAVLREMGTIDDLYVLEVRNGVERSIQFDTEALYDNSTRVLGYHAGQRSFELFFPDVVLTCVGCMETKTWILATTTGQLFFIDTLGQARCPRISIGHKIIKLCTSQSHVIAITETALIYVWDLVSMSLTLKNIPLLPLLARDPITGNRARFTSKIKSAKMTENKDLQLVMTDIAPDSDSNPSTLHFLYSSSLSCWCSPKEALLVDASVEQVITS
What is the function of this protein?
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
What are the official names of this protein?
Protein HIR1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat HIR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSRA_MANSM
Sequence: MLILTRKVGESLLIGDDISITILNVRGNQVKIGVNAPKDVSVHREEIYQRIKQAEEKESTS
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPH5_DICDI
Sequence: MVLYIIGLGLGDEKDVTIKGFEAIKKSSKIYLEAYTSLLGGSTSIEALEKFYEKKIIIADREMVESGCEEMLKESTENDVSFLVVGDPFGATTHTDLVIRAKELSIPVKVIHNASIMNAIGCCGLQLYSYGQTISMVFFTETTKPDSWYDRVKINRVNGMHTLCLLDIKVKEQSIENMCRGRLIYEPPRFMTVNQCIEQLLEIEEIRKEKVYDQDTLCIGLSRVGQDDQQIISGTMKELLDVDFGAPLHSFIICGDMHFIEKEYFETFRVKKN
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester.  The four successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine methyl ester synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: YOAF_SHIFL
Sequence: MKIISFVLPCLLVLAGCSTPSQPEAPKPPQIGMANPASVYCQQKGGTLIPVQTAQGVSNNCKLPGGETIDEWALWRRDHPAGEK
What are the official names of this protein?
Uncharacterized protein YoaF.
Protein: RN1_LITCL
Sequence: SMLSVLKNLGKVGLGLVACKINKQC
What is the function of this protein?
Antibacterial activity against Gram-positive bacterium S. aureus (MIC=55 uM) and Gram-negative bacterium E. coli (MIC=1. 5 uM).  Has activity against C. albicans (MIC=58 uM).
What are the official names of this protein?
Ranatuerin-1C.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Ranatuerin subfamily.
Protein: RL22_ACHLI
Sequence: MEAKAIGKTIRIAPRKVRLVVDLIRGKNVKEAQAILMFTPRGASPVIAKVLDSAIANATHNLNLNPENLFVKEVWANESITMKRMLPRAKGSGHLIRKRTSHITVVVAERE
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: VKT5_BUNFL
Sequence: MSSGGLLLLLGLLTLWAELTPVSSKDRPKYCNLPPEPGPCHGRKFAFYYHPASNKCKEFVYGGCGGNDNNFKTKDKCQRACSG
What is the function of this protein?
Snake venom serine protease inhibitor.
What are the official names of this protein?
Kunitz-type serine protease inhibitor isoform 5.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
Protein: HASA_SERMA
Sequence: MAFSVNYDSSFGGYSIHDYLGQWASTFGDVNHTNGNVTDANSGGFYGGSLSGSQYAISSTANQVTAFVAGGNLTYTLFNEPAHTLYGQLDSLSFGDGLSGGDTSPYSIQVPDVSFGGLNLSSLQAQGHDGVVHQVVYGLMSGDTGALETALNGILDDYGLSVNSTFDQVAAATAVGVQHADSPELLAA
What is the function of this protein?
Can bind free heme and also acquire it from hemoglobin.  Conveys heme from hemoglobin to the HasR receptor which releases it into the bacterium.  HasR alone can take up heme but the synergy between HasA and HasR increases heme uptake 100-fold.
What are the official names of this protein?
Hemophore HasA, Heme acquisition system protein A.
What are the subcellular locations of this protein?
Secreted.
Protein: S19A3_MOUSE
Sequence: MDSSCRTPPSNSWVYPTVILCLFGFFSMFRPSEAFLIPFLSEPSKNLTSPEMTNEILPVWTYSYLATLPPVFVLTDYLRYKPVIMLHVVAFATSYLFLLFGQGVMLMQTAEFFFGVVSATEIAYFAYIYSMVSPEHYQKVSSYCRSITLVAYTAGSVLAQLLVSLTNLPYSSLFYISLACVSVAFFFSLFLPMPKKSMFFHAKSDRDDCPKPLEQCTVPKEAQSNRTHSELFANSKNLEDREMSNPDPENSALRHFAHWFQDLKECYSSKHLVYWSLWWAFATAGYNQILNYVQVLWEHKAPSQDSSIYNGAVEAIATFGGALASFSVGYLKVNWDLLGELGLAVFSAVIAGSLFLMNYSRSIWVCYAGYLLVKSSYSFLITIAVFQIAVNLSLERYALVFGIDTFIALVIQTIMTMIVVDQRGLQLPVTTQFLVYGSYFAVIAGVFLMRSIYILCSAKCRKEVQNLATTRSPNEPHPQEPSNVSTKF
What is the function of this protein?
High-affinity transporter for the intake of thiamine.
What are the official names of this protein?
Thiamine transporter 2, ThTr-2, ThTr2, Solute carrier family 19 member 3.
What is the protein family that this protein belongs to?
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IHFA_ACIBC
Sequence: MTALTKADMADHLSELTSLNRREAKQMVELFFDEISQALIAGEQVKLSGFGNFELRDKRERPGRNPKTGEEIPISARRVVTFRAGQKFRQRVGNEQID
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: Y6890_HAEIE
Sequence: MPSFDIVSEITLHEVRNAVENANRVLSTRYDFRGVEAVIELNEKNETIKITTESDFQLEQLIEILIGSCIKRGIEHSSLDIPAESEHHGKLYSKEIKLKQGIETEMAKKITKLVKDSKIKVQTQIQGEQVRVTGKSRDDLQAVIQLVKSAELGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein CGSHiEE_06890.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: RISB_STAAC
Sequence: MNFEGKLIGKDLKVAIVVSRFNDFITGRLLEGAKDTLIRHDVNEDNIDVAFVPGAFEIPLVAKKLASSGNYDAVITLGCVIRGATSHYDYVCNEVAKGVSKVNDQTNVPVIFGILTTESIEQAVERAGTKAGNKGAEAAVSAIEMANLLKSIKA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: GUC1B_HUMAN
Sequence: MGQEFSWEEAEAAGEIDVAELQEWYKKFVMECPSGTLFMHEFKRFFKVTDDEEASQYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDGNGCIDRLELLNIVEGIYQLKKACRRELQTEQGQLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDMNPSSWLAQQRRKSAMF
What is the function of this protein?
Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity).  This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).  May be involved in cone photoreceptor response and recovery of response in bright light (By similarity).
What are the official names of this protein?
Guanylyl cyclase-activating protein 2, GCAP 2, Guanylate cyclase activator 1B.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=Subcellular location is not affected by light or dark conditions.
Protein: FOLD_CHLTB
Sequence: MLLKGAPAADHILATIKENIRACSKAPGLAVVLIGNNPASEIYVNMKIKRATDLGMVSKSYRKPSDATLSDILALIHQLNNDENIHGILVQLPLPKHLDAQAILSTITPDKDVDGLHPVNVGKLLLGETDGFIPCTPAGIVELCKYYEIPLHGKHVVILGRSNIVGKPLAALLMQRHADTNASVTLLHSQSEHLTEITRTADILISAIGVPLFVNKEMIAEKTVIMDVGTSRIPAANPKGYILVGDVDFNNVVPVCRAITPVPGGVGPMTVAMLMRNTWESFLRHTS
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: FTCD_RAT
Sequence: MSQLVECVPNFSEGNNQEVIDAISQAISQTPGCVLLDVDAGPSTNRTVYTFVGQPECVVEGALSAARTASQLIDMRKHKGEHPRMGALDVCPFIPVRGVSMDECVLCAKAFGQRLAEELNVPVYLYGEAAQMPSRQTLPAIRAGEYEALPEKLKQAEWVPDFGPSSFVPSWGATVTGARKFLIAFNINLLSTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLEEKNLAQVSTNLLDFEVTALHTVYEEARREAQELNLPVVGSQLVGLVPLKALLDAAAFYCDKEKLFVLEEEHRIRLVVNRLGLDSLAPFDPKERIIEYLVPDSGPEQSLLDASLRAFVREVGARSAAPGGGSVAAAVAALGAALASMVGQMTYGRRQFDHLDSTMRRLIPPFHAASAQLTSLVDADARAFAACLGAIKLPKNTPEERDRRTCALQEGLRQAVAVPLKLAETVSQLWPALQELAQCGNLSCLSDLQVAAKALETGVFGAYFNVLINLKDMTDDVFKEKTRHRISSLLQEAKTQAALVLGSLEARKE
What is the function of this protein?
Binds and promotes bundling of vimentin filaments originating from the Golgi.
What are the official names of this protein?
Formimidoyltransferase-cyclodeaminase, 58 kDa microtubule-binding protein, Formiminotransferase-cyclodeaminase, FTCD.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the formiminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=More abundantly located around the mother centriole.
Protein: MFS2B_MOUSE
Sequence: MSVPHGPTPAPVAEPHTQEPGSDKRDGRLSVCTKVCYGIGGVPNQVASSASAFYLQLFLLDVAQIPAAQVSLALFGGKVSGAVADPVAGFFINKSRRTGSGRLMPWALGCMPLIALAYFFLWFLPPFTSLRGLWYTSFYCLFQALATFFQVPYTALTMILTPSPRERDSATAYRMTMEMAGTLMGATVHGLIVSSAHGSQRCEDTVHPRSPAVSPDVARLYCIAAAVVALTYPVCGSLLCLGVKEQPDTSAPASGQGLNFFTGLAITSQHPPYLSLVVSFLFISAAVQVEQSYLVLFCTHASKLQDHVQNLVLIILVSAVLSTPLWEWVLQRFGKKTSAFGICVMVPFSILLAAVPSAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRCGPGVETIFYSSYVFFTKLSGAGALGISTLSLEFAGCEAGACQQAEEVVVTLKVLIGAVPTCMILIGLCILLVGPTPKMPRQDTSSQLSLRRRTSYSLA
What is the function of this protein?
Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386, PubMed:29563527, PubMed:33334894, PubMed:33863882).  Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (PubMed:29045386).  Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (PubMed:33863882).  Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (PubMed:33863882).  Release of sphingosine-1-phosphate is facilitated by a proton gradient (PubMed:33334894).  In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (PubMed:29563527, PubMed:33334894).  In addition to export, also able to mediate S1P import (PubMed:33785361).  Does not transport lysophosphatidylcholine (LPC) (PubMed:29045386).
What are the official names of this protein?
Sphingosine-1-phosphate transporter MFSD2B, Major facilitator superfamily domain-containing protein 2B, mMfsd2b.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the cell membrane and intracellular membranes.