PharMolix/UniProtQA huggingface dataset:
Protein: CEGTA_XENLA
Sequence: MAVLDLALQGLAIFGCVLFFVLWFMHFLSIVYTRLHLNKKISDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKFEILLCVQDLDDPAVDVCKKLLGKYPSDDAKLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIKVKPDTLTDMANQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKEVLDQAGGLIAFAQYIAEDYFMAKAIADRGWKFSMATQVAMQNSGCYSISQFQSRMIRWAKLRINMLPATIICEPISECFVASLIIGWAAHHIFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGPLNFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRFRLRCGGTAEEILDV
What is the function of this protein?
Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi.  Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) (PubMed:18095347).  Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures.  Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction.  They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (PubMed:18095347).  Glycosphingolipids are required for convergence extension movements during early development (PubMed:18095347).  Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (By similarity).
What are the official names of this protein?
Ceramide glucosyltransferase-A, XLCGT, Glycosylceramide synthase-A, UDP-glucose ceramide glucosyltransferase-A.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: CYAE_AMAPH
Sequence: MSDINAARLPSFFFPVPCISDDIEMVLTRGESLC
What is the function of this protein?
Cyclic heptapeptide that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:27978833).  Cycloaminide E is structurally related to other cycloamanides that are non-toxic to mammals but show immunosuppressive activity (PubMed:27978833).
What are the official names of this protein?
Cycloamanide E proprotein.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: LEPA_ACIB3
Sequence: MAQAKKSVDIKNIRNFSIIAHIDHGKSTLADRFIQMCGGLQDREMQAQVLDSMELERERGITIKAASVTLYYTHPNGQEYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAIEQGLEVLPILNKIDLPQAEPERVIHEIEEIIGIEATNAPTCSAKTGLGVEGVLETLVDVIPAPTGDREAPLQALIIDSWFDNYLGVVSLVRIKDGRIRKGDKMLVKSTGQTHIVTSVGVFNPKHTETGVLEAGEVGFVIAGIKDIFGAPVGDTITLSTTPEVASLPGFKKVKPQVYAGLFPIDASDFEPFREALQKLQINDSALFFEPESSDALGFGFRCGFLGMLHMEIVQERLEREYDLDLISSAPTVVYEAVTKKGDTIYIDSPSKMPDGSVVEDLREPIAECHILVPQEYLGNVMTLCIERRGVQKDMKFLGNQVSITFEIPMAEVVMDFFDKLKSCSRGFASLDYNFIRFESSSLVKVDVLINGEKVDALAMICHRNDARHRGIALVEKMKDLIPRQMFDVAIQAAIGAQIIARSTVKAMRKNVLAKCYGGDVSRKKKLLAKQKEGKKRMKQVGSVEIPQEAFLAVLKVER
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS13_THEVB
Sequence: MARIAGVDLPRDKRIEIALTYIYGIGLTRSKEILAKTGVNPDTRTRDLTDADIAALRAAIDEYQVEGDLRRLEAMNIKRLMDIGCYRGRRHRLGLPVRGQRTRTNARTRRGSRRTVAGKKKPAAKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: ATP9B_HUMAN
Sequence: MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCDGWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLYTYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYRNLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMMKDENIPGTVVRTSTIPEELGRLVYLLTDKTGTLTQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSRIHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTESVGLTLVSRDLTSMQLKTPSGQVLSFCILQLFPFTSESKRMGVIVRDESTAEITFYMKGADVAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPEMAMLYPELYKDLTKGRSLSFKTFLIWVLISIYQGGILMYGALVLFESEFVHVVAISFTALILTELLMVALTVRTWHWLMVVAEFLSLGCYVSSLAFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCLPLYVLKYLRRKLSPPSYCKLAS
What are the official names of this protein?
Probable phospholipid-transporting ATPase IIB, ATPase class II type 9B.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B.
Protein: YEEX_ECOSM
Sequence: METTKPSFQDVLEFVRLFRRKNKLQREIQDVEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKGDYEDRVDDYIIKNAELSKERRDISKKLKAMGEMKNGEAK
What are the official names of this protein?
UPF0265 protein YeeX.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: RECA_BACFR
Sequence: MDKIEKSFGKGSIMKMGEEVVEQVEVIPTGSIALNAALGVGGYPRGRIIEIYGPESSGKTTLAIHAIAEAQKAGGIAAFIDAEHAFDRFYAAKLGVDVDNLFISQPDNGEQALEIAEQLIRSSAIDIIVVDSVAALTPKAEIEGDMGDNKVGLQARLMSQALRKLTSAVSKTRTTCIFINQLREKIGVMFGNPETTTGGNALKFYASVRLDIRGSQQIKDGEEVIGKQTKVKVVKNKVAPPFRKAEFDIMFGEGISHSGEIIDLGADLGIIKKSGSWYSYNDTKLGQGRDAAKQCIADNPELAEELEGLIFEKLREHK
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_WOLTR
Sequence: MNNIVIVGLQWGDEGKGKIVDYLSENADTVVRFQGGNNAGHTIVVDDEVYKLNLLPSAVLRTGKISIIGNGVALDPYALISEIESLRVKGMDINPNNLMVSESCPLILSVHKEKEKLFEDLNGNHKIGTTNKGIGPCYEDKVGRRAIRLCDLENADELNKRLDTLLNYHNAIRKGLSYRVIKKEEMLREIEEIAEKIIPYRKPVWKILNDFVKEGKKIIFEGAQGTFLDIDHGTYPFVTSSNTIASQVMTGSGLSSNAYVIGVAKAYTTRVGNGPFPTEQRNEVGNSLFTIGKELGTVSNRKRRCGWFDAVLVRQAVQLSGVSSIILTKLDVLDSFDKIKICTGYQYSGKIYDYLPASRSIQEELEPIYEEFPGWKENTQGEKLAEKLPVNLIKYVKRVEELIGIPIHLISAGPKREDVIKLKDFKFSESVLVSY
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LZTS2_BOVIN
Sequence: MAIVQTLPVPLEPAPEAATAQQAPAMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPGTNFTYINEDFRTESPPSPSSDLEDAREQRARNAHLRGPPPKLIPVSGKLEKNMEKIVIRPTAFKPVLPKPRGVPSLPSFLGPRATGPSGSQGSLTQLFGGPASSSSSSSSSAADKPLILSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPATNSPGGHLPSHGPGRGALPGPARGAPTGPSHSDSGRSSSSKSTGSLGGRLAGGLLGSGPRASPDSSSCGERSPPPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDESEVTMCQVYEERQRHWPREREALREDGVARAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCAAFEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQSELVQKGSELVALRVALREARAALRVSEGRARGLQEAARTRELELEACSQELQRHRQEAERLREKAGQLDSEAAGLREPPVPPATADPFLLAESDEAKAQRAAAGVGGSLRAQVERLRAELQRERRQGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEPAPCICLEEITATEI
What is the function of this protein?
Negative regulator of katanin-mediated microtubule severing and release from the centrosome.  Required for central spindle formation and the completion of cytokinesis.  May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon.  Negative regulator of the Wnt signaling pathway.  Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
What are the official names of this protein?
Leucine zipper putative tumor suppressor 2, Protein LAPSER1.
What is the protein family that this protein belongs to?
Belongs to the LZTS2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
Protein: PTH_ECOHS
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTEMWFTDGLTKATNRLHAFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDR1_AEDAE
Sequence: MDRWAGKVAVVTGASSGIGAAITTDLAKAGMVVVGLARRVERVEALKANLPESAKPRLHAVKCDVSKEEDITQVFKWVEKKFGGVDVLVNNAGILRQTDLLGTDNGQMLREVLDTNVMGLVLCSQKAYQSMKKRSVDGHIVHINSVVGHKVFDFPQSNIYPASKHAVTAITETMRNELRNAGSRIKVTSISPGVVRTEILPESIIEGGHALLESEDISEAVLYVLGTPPRVQVHELTIKPVGEKF
What is the function of this protein?
Mediates oxidation of farnesol into farnesal, a precursor of juvenile hormone in the corpora allata (CA), the glands that synthesize juvenile hormone.  Able to oxidize C(10) to C(15) isoprenoid and aliphatic alcohols.
What are the official names of this protein?
Farnesol dehydrogenase, NADP(+)-dependent farnesol dehydrogenase 1, AaSDR-1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PSBR_ARATH
Sequence: MAASVMLSSVTLKPAGFTVEKTAARGLPSLTRARPSFKIVASGVKKIKTDKPFGINGSMDLRDGVDASGRKGKGYGVYKYVDKYGANVDGYSPIYNENEWSASGDVYKGGVTGLAIWAVTLAGILAGGALLVYNTSALAQ
What is the function of this protein?
Associated with the oxygen-evolving complex of photosystem II.
What are the official names of this protein?
Photosystem II 10 kDa polypeptide, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the psbR family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: KELP_ARATH
Sequence: MEKETKEKIEKTVIEILSESDMKEITEFKVRKLASEKLAIDLSEKSHKAFVRSVVEKFLDEERAREYENSQVNKEEEDGDKDCGKGNKEFDDDGDLIICRLSDKRRVTIQEFKGKSLVSIREYYKKDGKELPTSKGISLTDEQWSTFKKNMPAIENAVKKMESRV
What is the function of this protein?
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery.  Binds single-stranded DNA (By similarity).
What are the official names of this protein?
RNA polymerase II transcriptional coactivator KELP.
What is the protein family that this protein belongs to?
Belongs to the transcriptional coactivator PC4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU4C_ANTAG
Sequence: MSNFPWLTIIVLLPISAGLLIPLLPNKGNRIIRWYTLGICLVEFLLITYIFCNYFHFDNQFIELKEDYNWINLLDFHWRLGIDGLSIGLILLTGFITTLATLAAWPITRNPRLSYFLMLAMYSGQVGLFASQDILLFFFMWELELIPVYLLLSMWGGKRRLYAATKFILYTAGSSVFLLMGALTMGLYGSDGPTLDFENLANRSYPIGLEIILYLGFFIAYAVKLPMVPLHTWLPDTHGEAHYSTCMLLAGILLKMGGYGLIRINMELLSHAHSIFAPWLVVIGAIQIVYSALTSLSQLNLKRRIAYSSVSHMGFVLIGIGSTTDIGVNGAILQMISHGLIGAALFFSAGVTYDRTRTLFLNQMGGIATSIPKIFTMFSSFSMASLALPGLSGFVAELMIFLGIVSSQNFSFLFKVVIIIVAATGIILTPIYLLSMLRQMFYGYRIIKNLTSYVTDAGPREIFIFICLFFPIIGIGFYPKLVLSLSNSKVESIISGNFSSK
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y958_STAA2
Sequence: MNPIVEFCLSNMAKGGDYVFNQLENDPDVDVLEYGCLTHCGICSAGLYALVNGDIVEGDSPEELLQNIYAHIKETWIF
What are the official names of this protein?
UPF0349 protein SaurJH1_0958.
What is the protein family that this protein belongs to?
Belongs to the UPF0349 family.
Protein: SYA_META3
Sequence: MEIKHDYNVQLFKEKGFIRKQCKECNQYFWTLDPKRETCGDSPCDEYSFIGSSITNKEYTYNEMVKEFLNFFDKNGHTPIKRYPVSARRWRDDILLTIASIAVFQPWVTKGIVKPVANPLVIAQPCIRLNDIDNVGRTGRHMTCFTMGGHHAFNTDEDFKYWTDRTVELCYNFFTNLGIDGSSITFIESWWEGGGNAGPCYEVITHGVELATLVFMQYEKTEQGDYIEMPLKIVDTGYGLERFVWASKGTPTVYEAVFGDIIGKLMDDANINMNDIGPKILAESATLAGLMDIENVGDLRILRQKVAEKLNLDVNELDSILSPIENIYAIADHTRCLAFMLGDGIVPSNVKDGYLARLLVRKTLRYIKNVGLSLSLKDIVAMQLENLKEIYPELMDMKEYIMDVLEEEENKYIQTITKGKGAVERIAKSKDEITLDDLIELYDSKGLPPEVVRDIVEEINKKGSKNNKGNKTIKITVPDNFYTIVAERHEEKKEDSKSEKGENTAEKSTISINLDDIPETELLFYSNPYQKEVEAKILKIIGNVVILDKTVFYPEGGGQKYDIGLIGNKKIISVQKNNNGIVCHTVENTDGLNEEDTIIAKLNWENRLNLMRNHTATHIINAAASKVLGKHIWQTGSNVESNKARLDITHYKRITREEIKEIEKIANQIVLDAIPVKSTVMGRNEAEQKYGFKIYQGGVVPGNILRILDIEGVDVEACGGTHCQNTSEVGYIKILKTERIQDGVERLEYTSGINSVNEVSLMEDILLNASSIVGVPCENLPKTVNRFFEEWKEQKKIIEELHKKIGELEKGNLNDKFEKVGKYDLLVEKVEGAPKELMSIADNLVNEKDNSIVILLNNSGYILCKCGEKVEIKMGELLRKIAKGGGKDKMAQGKCADDIETLKSKVVGEL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_PARDP
Sequence: MKDLTSSDADALIADLGQKARAAAAVLAEASAERKHAALIGAADAILEAEDAILDANAEDMHYAEEKGLSPAMLDRLKLDPARIRAMAEGLRSVAAQADPVGKVLAEWDRPNGLNIRRVATPLGVIGVVYESRPNVTADAAALALKAGNAVILRGGSESLNSSAAIHRALVTGLKQAGLPETAIQMVPTRDREAVAAMLRAQDYIDVIVPRGGKGLVGLVQKEARVPVFAHLEGICHVYADRDADLDKARRVVLNAKTRRTGICGAAECLLIDWQFYTKHGPVLVQDLLDAGVEVRAEGELAKVPGTVPAEPSDFGQEFLDKIIAVKLVDGVEEAIAHIRRHGSGHTESILTENDATAERFFSGLDSAILMRNASTQFADGGEFGMGAEIGIATGKMHARGPVGAEQLTSFKYLVTGDGTIRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DJC10_XENLA
Sequence: MKHSLNTATSSSSVLKRTILYLVLISLAALVYCDDDYYDLLGVSKAATNREIRQAFKKLALKLHPDKNKDPDAHNKFLKINRAYEVLKDEDLRKKYDKYGEKGLDEQNQGGGYQSWSYYRYDFGIYDDDLEIITLDRGEFDGAVNSGELWFINFYSPGCSHCHDLAPTWRQFAKEMDGLLRIGAVNCGDNRMLCRSQGINSYPNLYIFKSGMNPVKYYGERSKERLVNFAMPYISSTVTELWAGNFRSSIEDAFSSGVGWLITFCSDTGDCLNSQTRSKLAGLLEGLVKVGWMDCATQGDLCDNLEITSSATVYFPPGSTLTDKENGDVLFLNSLDAREIYKEVLNHLPDLETISPESLQGKLSHHRWLLFFTFGTDEQSSLPEFKKLTVHLRSEHVQVGKFDCYSSPSICSELYIHKPCVAAFKGKGISAYEIHHGKVQLYDLVSFAKESVNSHVITLGPTNFPGKDRDTWLVDFFAPWCPPCRALLPELRIASKRLFGQIKFGTLDCTIHEGLCNMHNIRAYPTTVVFNHSNIHEYAGHNNAEEILEFIEDLRNPSVVTLTPETFQSLVRNRRGDEMWMVDFYAPWCGPCQALMPEWKRMARHINGLISVGSIDCQKYSLFCTQERVNGYPEIRLYPANINPQHTYYRYTGWHRDSQSLRNWALMYLPKASFDLTPESFHEHVINGKDNWVLDFYAPWCGPCQNFNPEFEILARAVKGKIKAGKVNCQAYEHLCNSASIRSYPTVRLYPYNGSKKKDYFGEQIDSRDAKEIAQIITKRIEAIKRVKEAYNKDEL
What is the function of this protein?
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.  Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins.  Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins (By similarity).
What are the official names of this protein?
DnaJ homolog subfamily C member 10.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: Y607_ENCCU
Sequence: MNTTHVPEPHRTEQHTENQRHWRKILDIAPIVSIAFPAAMYFIFDEDSFEGSLFLRFVTVLLPFSYSAVQYAVLLHTNRMPHNKPEGILQSMLYYTLNLLLLAFTIISILSIIAFTLDEWENNDDSLLYSITLPSFFIPLTYLLSVSCRLVPGQIGFTDTGINVLIDILILLFPRTALVSKESKHRLLYAVLFLLPILIRLLKEKYCPSGKSSLPTASWRVAVLALILILVFFAYTFMMCRSMVILNNHFGLLNKLKRVSAPSRSDK
What are the official names of this protein?
UPF0328 protein ECU06_0070.
What is the protein family that this protein belongs to?
Belongs to the UPF0328 family.
Protein: RL31_THIDA
Sequence: MKAGIHPDYNEVTVTCSCGNTFVTRSTLGKPALHVEVCASCHPFYTGKQKIVDTAGRVEKFRQRYGMK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: MLTC_YERPP
Sequence: MKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAGPKDYVKYTDQYQTRSHINFDAGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYLLQNKMQTRTSGLHVISFVTIQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNGGAGSVLRVFHSDKNKAVGIINTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RPIA_PICGU
Sequence: MLPTFVRFSRIMSSGIEHAKRMAAYKAVDANFPPHAKVVGIGSGSTVVYVAERIGQLKNKHDFVCISTGFQSKQLIIDNGLTLGAIEQFPKVDIAFDGADEVDTNLNLIKGGGACLFQEKLVASSADKFIVVADTRKKSPSDLGIAWRKGVPIEVVPNSYAVVTRQLKELGAKSVVLRQGGGAKAGPVVTDNNNFLIDADFGSISDPGSLHQQIKLLVGVVETGLFVDMAHTAYFGDESGEVSEQSR
What are the official names of this protein?
Ribose-5-phosphate isomerase, D-ribose-5-phosphate ketol-isomerase, Phosphoriboisomerase.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPSE_HUMAN
Sequence: MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
What is the function of this protein?
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.  Participates in extracellular matrix (ECM) degradation and remodeling.  Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group.  Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety.  It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes.  Facilitates cell migration associated with metastasis, wound healing and inflammation.  Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas.  Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII.  Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity.  Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion.  Heparin increases this AKT1/PKB activation.  Regulates osteogenesis.  Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF.  Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
What are the official names of this protein?
Heparanase, Endo-glucoronidase, Heparanase-1, Hpa1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 79 family.
What are the subcellular locations of this protein?
Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity).
Protein: SYK_GEOSE
Sequence: MSHEELNDQLRVRREKLKKIEELGVDPFGKRFERTHKAEELFELYGDLSKEELEEQQIEVAVAGRIMTKRGMGKAGFAHIQDVTGQIQIYVRQDDVGEQQYELFKISDLGDIVGVRGTMFKTKVGELSIKVSSYEFLTKALRPLPEKYHGLKDIEQRYRQRYLDLIMNPESKKTFITRSLIIQSMRRYLDSHGYLEVETPMMHAVAGGAAARPFITHHNALDMTLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGISTRHNPEFTMLELYEAYADFRDIMKLTENLIAHIATEVLGTTKIQYGEHLVDLTPEWRRLHMVDAIKEYVGVDFWRQMSDEEARELAKEHGVEVAPHMTFGHIVNEFFEQKVEDKLIQPTFIYGHPVEISPLAKKNPDDPRFTDRFELFIVGREHANAFTELNDPIDQRQRFEEQLKEREQGNDEAHEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSPSIRDVLLFPQMRHK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.