PharMolix/UniProtQA huggingface dataset:
Protein: CLPB_VIBVY
Sequence: MRLDRFTSKFQIAISDAQSLALGRDHQYIEPVHLMVALLDQNGSPIRPLLTILNVDVTHLRSKLSEMLDRLPKVSGIGGDVQLSSAMGAMFNLCDKIAQKRQDAYISSEIFLLAAIEDRGPLGQLFKELGLTEQKVSQAIEQIRGGQKVNDQNAEELRQALEKFTIDLTERAEQGKLDPVIGRDDEIRRTIQVLQRRTKNNPVIIGEPGVGKTAIVEGLAQRIINNEVPEGLRGRRVLSLDMGALVAGAKYRGEFEERLKSVLNELSKEEGNIILFIDELHTMVGAGKGEGSMDAGNMLKPALARGELHCVGATTLDEYRQYIEKDPALERRFQKVLVDEPTVEDTIAILRGLKERYELHHHVEITDPAIVAAASLSHRYVSDRQLPDKAIDLIDEAASSIRMQIDSKPEALDKLERKIIQLKIEQQALSNEHDEASEKRLRSLNEELNEKEREFAELEEIWNAEKAALSGTQHIKAALEQARMDMEFARRAGDLSRMSELQYGRIPELEKQLDLATQAEMQEMTLLKNKVTDNEIAEVLSKQTGIPVSKMLEAEKEKLLRMEEVLHKRVIGQKEAVEVVANAIRRSRAGLSDPNKPIGSFLFLGPTGVGKTELCKTLANFMFDSEDAMVRIDMSEFMEKHSVARLVGAPPGYVGYEEGGYLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNLGSSRIQENFAMLDYQGIKEQVMEVVTKHFRPEFLNRVDETVVFHPLSQDHIKSIAAIQLNRLANRMEEHGYQLEVSDKALELIAQVGFDPVYGARPLKRAIQQSIENPLAKSILAGSVLPDKKIQLIVNNDQIVAHQ
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLO_PHOPR
Sequence: MTNDNLYRYLFEGVSVRGELVQLGNTYQQIIASKEYPAPVQKLLGELLVATSLLTATLKFEGSITVQLQGDGPVRLAVINGDHEQKMRGVARWEGEVPTDGTIHDVIGKGHLVITITPTKGDRYQGVVGLEGDTLAESLEGYFANSEQLKTRIILRTGEFEGNAKAAGMLLQILPDGQGQEGDFEHLEQLTETVKDEELFGLDAQDVLYRLYHQEEVKLFDPQSVEFHCGCSRERSASAICSIERIEVEKIIADEGKVSLHCDYCGTSYDFDSIDVAALHENAAKNDRDQVH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP16_ARATH
Sequence: MGVDPFKTTETLEADKETNGGVPVKDKLTFKAPERKSRLGLDARAIEKKDNAKTEGEFKVPKKSAISVTSSLDEEDKSDVSGLDFGTENTRPVHSSRRYREKSSRSQSAQESTVTTENAGTSDISITPRTLSCTSSYERGGSNRHREEHRRDRSETPRSRQRNTYDEMDHYRRRESYRQSDRDYHGEKRRRYNSDWRTPGRSDWDDGQDEWERSPHGDRGSSYSRRPQPSPSPMLAAASPDARLASPWLDTPRSTMSSASPWDMGAPSPIPIRASGSSIRSSSSRYGGRSNQLAYSREGDLTNEGHSDEDRSQGAEEFKHEITETMRVEMEYQSDRAWYDTDEGNSLFDADSASFFLGDDASLQKKETELAKRLVRRDGSKMSLAQSKKYSQLNADNAQWEDRQLLRSGAVRGTEVQTEFDSEEERKAILLVHDTKPPFLDGRVVYTKQAEPVMPVKDPTSDMAIISRKGSGLVKEIREKQSANKSRQRFWELAGSNLGNILGIEKSAEQIDADTAVVGDDGEVDFKGEAKFAQHMKKGEAVSEFAMSKTMAEQRQYLPIFSVRDELLQVIRENQVIVVVGETGSGKTTQLTQYLHEDGYTINGIVGCTQPRRVAAMSVAKRVSEEMETELGDKIGYAIRFEDVTGPNTVIKYMTDGVLLRETLKDSDLDKYRVVVMDEAHERSLNTDVLFGILKKVVARRRDFKLIVTSATLNAQKFSNFFGSVPIFNIPGRTFPVNILYSKTPCEDYVEAAVKQAMTIHITSPPGDILIFMTGQDEIEAACFSLKERMEQLVSSSSREITNLLILPIYSQLPADLQAKIFQKPEDGARKCIVATNIAETSLTVDGIYYVIDTGYGKMKVFNPRMGMDALQVFPISRAASDQRAGRAGRTGPGTCYRLYTESAYLNEMLPSPVPEIQRTNLGNVVLLLKSLKIDNLLDFDFMDPPPQENILNSMYQLWVLGALNNVGGLTDLGWKMVEFPLDPPLAKMLLMGERLDCIDEVLTIVSMLSVPSVFFRPKERAEESDAAREKFFVPESDHLTLLNVYQQWKEHDYRGDWCNDHYLQVKGLRKAREVRSQLLDILKQLKIELRSCGPDWDIVRKAICSAYFHNSARLKGVGEYVNCRTGMPCHLHPSSALYGLGYTPDYVVYHELILTTKEYMQCATSVEPHWLAELGPMFFSVKDSDTSMLEHKKKQKEEKSGMEEEMEKLRRDQVESELRSKERERKKRAKQQQQISGPGLKKGTTFLRPKKLGL
What is the function of this protein?
Involved in pre-mRNA splicing by mediating structural transitions of the spliceosome during the catalytic step.  Facilitates expression of genes involved in auxin-mediated development including male-gametophyte transmission, apical-basal patterning of embryonic and gynoecium development, stamen development, phyllotactic flower positioning, and vascular development (PubMed:25384462).  Also involved in root-meristem maintenance and planar polarity of root-hair positioning (PubMed:26237376).  Acts as a component of RNA silencing that regulates distinct classes of endogenous small RNAs.  Functions as a positive regulator of plant immunity (PubMed:25902521).
What are the official names of this protein?
Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7, DEAH RNA helicase homolog PRP16, Protein CLUMSY VEIN, Protein EMBRYO DEFECTIVE 3011, Protein PSR1-INTERACTING PROTEIN 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Binds to the spliceosome.
Protein: MTGA_NITWN
Sequence: MRRAIRVMALSAIGLLLLPYLLTPLYRIGHPVSTLMIWRTLSGAPMSRQWIDFAALPPSLPRSVVASEDAKFCSHQGIDWDSLREVLDDAEDGEFKRGGSTITQQVAKNLFLWPGRSMVRKALEFPLAMWIDAVLSKQRILEIYLNIAEWGPGGQFGVEAGSRYAFGRSAASLTAREAALMAAILPNPVRRSARKPGPGVRRLAGTYMARARAAELRGCWSGNRSL
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SDS3_HUMAN
Sequence: MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYLGQLQRGLFVIRRRSAA
What is the function of this protein?
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1.  May have a potential role in tumor suppressor pathways through regulation of apoptosis.  May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
What are the official names of this protein?
Sin3 histone deacetylase corepressor complex component SDS3, 45 kDa Sin3-associated polypeptide, Suppressor of defective silencing 3 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SDS3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: URK_SHESR
Sequence: MNSQQCVIIAIAGASASGKSLIAKTIFDELRRDLGTDQIGVINEDAYYRDQSHLSMDERVLTNYDHPKALDHQLLCTHLQLLKSGEAVDIPCYSYTEHTRMAETVKMTPKKVIILEGILLLTDPKLRELMDASVFMDTPLDICFLRRLTRDVAERGRTMESVISQYKKTVRPMFLQFIEPSKQYADIIVPRGGKNRIATDILKTRIQHLLAK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMEN_LYMST
Sequence: METIGFMKNIETFAFPKQETVAMDDRAAASNFLGQPPVGGPPVKDLSALKRPASEMVKSHVGLFSPVKRRRHCGHSSVSDLARSASCVRSLAMKAKNTWMSNVPVMSSTHLVKRECPPVQGADLSDNLATASSPAHTGKGYTPFEDICLKQLLEVSRHKLFRSLEEVRGSDVRHDSRCDVPRAVRCRSLPSRMTPEKNSAEVSIGGLKDQSPSTSIRSNLVSSLLGVSRRDDQETSDSCHDDDDDRAINDSERYDVSECDESGPPTPSSGFIDIEADTPPCSPLNLTTTGGDSVSQLFHSSGHGVGDRQRNTASTDAKSSHIKSKSEDATKDKLGPCCCCGTTCSGGTCKEKKTNFSIDAILRPDFGSGNFLGQDGHTFQPNEDHQTVSSAQTTPRFSSPDSAFKVVDLRTRSRSESLSSPSSSSSSSRSSPSPPLTSPVSLRQKWERQTGSFMRRHLKGQEHFNFPQSLFPNPSKDLENFIGRDFPFISPPQGNPLVKFPNIFPDQLSHLHPAMPAECVDPRTFYYAPENFLSKGQQPLLSYDMSKLFGRSLHPFLNSPPKPQPQKRPGHHLAPTPVEGVTLKSVGTNHNPKVLPEVKTPVQSPQGDQKKRSRDESASKGKQVADQNVHLKENSQKSDPVLKQEKGNRKVSPAGASPETDKAKNPLWPAWVFCTRYSDRPSSGPRSRKPKRSKAQDEKRPRTAFTNDQLQRLKREFDECRYLTETRRKNLADELGLTESQIKIWFQNKRAKIKKSVGVRNPLALQLMEQGLYNHSTIKEMMEEGMYPHTPSQAGDDSS
What is the function of this protein?
May be involved in shell and shell gland formation during development.
What are the official names of this protein?
Homeobox protein engrailed, Lsten.
What is the protein family that this protein belongs to?
Belongs to the engrailed homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CEF1_CANAL
Sequence: MAPPLYVKGGVWTNVEDEILKAAIQKYGIYQWERISSLLPKKSAKQVKARWVEYLSPLLNKTDWTKEEDEKLLNLHKIFPNQWRSISNILNRTAVQCVERYQKLIDEAAGIKPGDDEENLGLSGPGIETLPAVGASSGLAVGEMNLNPESKPARPDDEDLPDDEREMLAEAKARLGNIQGKKAKRKARERMLEESKRIALLQKRRELKSAGINVKLTTRNKKKRKEFDYNADIPHEIIPQAGPYDTAEELKQNDFEKQQFGQQVSTKGISMKDIDDRIAKEESRRKKEIEKKKLERKREFNAAASLISEHEDSKRRKLNLPEPGTHNFEKTKSDVLTLTNQANNKLSEKEIARNQNKKRAAVAQLIKATFERLPPPKHETGEILPFVSTNILEFRNDVNANDISDIAGAKLPDETATNVSTLISRVVQRELPIPHPNNLRDLSTVKFDTLVDKLIAEECHRLIRSDYKQYHDTTINGVSTDKYDRDLLEKINQDIDKEFAQMDVSTVHSFEDYVLPKNFKVAESIIENLHTFHNENEKLTNKILESTNYEDQRDQKLQQLTHLWRELSDVNLSYSIEKKLFELESSAIDKELLRLRSEIDKLNKKIETLR
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle control.
What are the official names of this protein?
Pre-mRNA-splicing factor CEF1.
What is the protein family that this protein belongs to?
Belongs to the CEF1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BGLA_THENN
Sequence: MKKFPEGFLWGVATASYQIEGSPLADGAGMSIWHTFSHTPGNVKNGDTGDVACDHYNRWKEDIEIIEKIGAKAYRFSISWPRILPEGTGKVNQKGLDFYNRIIDTLLEKNITPFITIYHWDLPFSLQLKGGWANRDIADWFAEYSRVLFENFGDRVKHWITLNEPWVVAIVGHLYGVHAPGMKDIYVAFHTVHNLLRAHAKSVKVFRETVKDGKIGIVFNNGYFEPASEREEDIRAARFMHQFNNYPLFLNPIYRGEYPDLVLEFAREYLPRNYEDDMEEIKQEIDFVGLNYYSGHMVKYDPNSPARVSFVERNLPKTAMGWEIVPEGIYWILKGVKEEYNPQEVYITENGAAFDDVVSEGGKVHDQNRIDYLRAHIEQVWRAIQDGVPLKGYFVWSLLDNFEWAEGYSKRFGIVYVDYNTQKRIIKDSGYWYSNVIKNNGLTD
What is the function of this protein?
Broad substrate specificity glycosidase.  Releases glucose from soluble glucooligomers, with a preference for longer oligomers; acts more readily on cellotetraose than on cellobiose.  Displays similar activities towards the disaccharides lactose and cellobiose.  Is also able to hydrolyze various aryl-beta-glycosides in vitro.
What are the official names of this protein?
1,4-beta-D-glucan glucohydrolase, Glucan glucohydrolase, Beta-D-glucoside glucohydrolase, Beta-glucosidase, Glucan 1,4-beta-glucosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: IRC3_SCHPO
Sequence: MLLNACCKKNLWPRNGSTIFRRFALKLRPYQEECLSACLNAFDEGKRRIAVSLATGSGKTALFPHFIKYAPTLRPNSEQCLILVHRKELALQALKHCRESLPNKSIEIDMGNQCASGLADVTVASVFSLKNERLLKYNPLNFKLLIFDEVHHMASPSYLRILEHFGAESEKSKVNVIGLTATLFRADGKGLACGLDEIVYHRHFVDMIKDNWLVEPKVINIKWSTDLVLADSSSFLDQEKLKKEAQSEKAIFEIPRAWLEHASNRSSTLVFCINVEHSLKVCNAFRKLGIDARALFGETNDSERETLIQDFRKKKFPVLVNCMVLTEGTDIPNIDCLMIARPTSSPNLLTQMIGRGLRLHEGKRDCLILDFCDSLRRVSLHVDPTLAGLSPDEVENFYNKSKNSLANPDYDPKIYGLQSVLWYSKLRKLIEMMDNIKNKDRSIFNLSTNAWVAVGMGRYVLSFLQKVLIIDTNFEDGTHKISEYTKEKLGTRVYNRKRIVSDRIPSLKFAIRAAETYISNLKTPRSLISRKAVWRMRPASVRQINFLKKSNLKLDEKLLTAGVAADMITKVIYGGKGRQVRTDKLQSYLKHDANLKRITTLKELKG
What are the official names of this protein?
Putative mitochondrial ATP-dependent helicase irc3.
What is the protein family that this protein belongs to?
Belongs to the helicase family. IRC3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HMDH_HUMAN
Sequence: MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
What is the function of this protein?
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:2991281, PubMed:21357570, PubMed:6995544).  HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668).
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
Protein: Y035_MYCPN
Sequence: MKAFRKLLLGLALPTTIGPLLGLLLTNTDTVKNESLTTVRHRSSINQDFDGIFHTVKLLEPIQQSNADPAASFALFQQKFPNLKRVANSTLNTFDVYNLLSGWKSSLTAYLNQVLALQQRIKAADQIFPNQKETLPKDENPNIFEVLGAYGGKGFFPTLGSNGLHLPPQLFQFFRDFQLSSFTIKDFEVALVSEPDIVQHDKVRYAFQVQFNLVLQLQINRNPVLFDFNLQLKTNNFANQTSFDELFNEKTNPLNWQFFSKLKVNHLVYEGNDITQLANTLLQSQFNVLQLDLNKSIYRLNLNAMAQRFEHDWVQPLYAKRTQAKIAYEAEQARIAAENKRKELERQKLLAELKAKAEHYQKIKQARENMLKGLKSITDFVKFWKSPDRLLVGFNKQDDITTRAGVYKALQIAYANYPQWTFYLTLQGWKNGSELLLKRPSWTNLLSDIHFQKAFNLKNTVSEQTLGAATLPGYGYYGLRMSDWLRWALGYYSYIHMGVPQNVQTKFTGTPDNEQQVWIANEPFEWNKHYGVGPKYKDKAYRFNMEISFELEGWIAVKWWAWAFKGSIPGNWKGKLKVTHLFDGMVPVWELGPVNTHLPQYSFTDQQQLLFVPHSIQKIEAIGADKGINDLLKTQNLHNLERLSYESTNPIDLISYLLYAIQYIKV
What are the official names of this protein?
Uncharacterized protein MPN_035.
What is the protein family that this protein belongs to?
Belongs to the MG032/MG096/MG288 family.
Protein: GLSA_PSEA6
Sequence: MQNIVDSIYQEMRSRTDRGKVANYIPQLACVDPNQFALTVVTQEGEVFSAGCAQTLFSIQSISKVFTLTMALGKLGDALWAQVGREPSGDPFNSIVQLEHEGGIPRNPFINAGAIAVADAIMGHNEPKETLAEILHFVRFVANDDSISIDEKVAQSEMMTGSRNASLAHFMASFERLENPVDKVLGTYFHHCSISMTTEQLARAGMFLVSNGTNHCTGMRVVPEHRARRINSLMLMCGHYDGSGEFAYRVGLPGKSGVGGGILAIAPGKASIAVWSPGLDKIGNSKLGTEALEMLVQETGWSIFGH
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: CLPP_RICPR
Sequence: MSYVPVVIEQTSRGERAYDIYSRLLKERIIFVCSTVEDHMANLIVAQLLFLEAENPKKDIYMYINSPGGVVTAGLAIYDTMQFIKPKVATLCIGQACSMGSLLLCGGEHGMRYSLPHSRIMIHQPSGGYKGQATDIEIHARETLKIKRLLNELYSKHTKQELKYIEKSMERDNFMSSEEAKKFGLVDNIISSRDTIAFLAQ
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDH_STAAC
Sequence: MAQDRKKVLVLGAGYAGLQTVTKLQKAISTEEAEITLINKNEYHYEATWLHEASAGTLNYEDVLYPVESVLKKDKVNFVQAEVTKIDRDAKKVETNQGIYDFDILVVALGFVSETFGIEGMKDHAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGELTDRIPELCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYLEDRGVEFKIATPIVACNEKGFVVEVDGEKQQLNAGTSVWAAGVRGSKLMEESFEGVKRGRIVTKQDLTINGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNIKRILNGESTEEFEYVDRGTVCSLGSHDGVGMVFGKPIAGKKAAFMKKVIDTRAVFKIGGIGLAFKKGKF
What is the function of this protein?
Alternative, nonproton pumping NADH:quinone oxidoreductase that delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones, and contributes to the regeneration of NAD(+).
What are the official names of this protein?
Type II NADH:quinone oxidoreductase, NDH-2.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RS3_YERPG
Sequence: MGQKVHPNGIRLGIVKAWNSTWYANTKEFADNLDSDFKVRQFLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: EUTC_SALTY
Sequence: MDQKQIEEIVRSVMASMGQDVPQPAAPSTQEGAKPQCAAPTVTESCALDLGSAEAKAWIGVENPHRADVLTELRRSTAARVCTGRAGPRPRTQALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLSPEAIDALKSQCVMNPDVQVVVSDGLSTDAITANYEEILPPLLAGLKQAGLNVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRVATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
What is the function of this protein?
Expression of the eut operon allows this bacteria to use ethanolamine (EA) as a carbon, nitrogen and energy source.  It relies on cobalamin (vitamin B12) both as a cofactor for the ethanolamine ammonia-lyase activity and to induce the operon.  EA enhances bacterial survival in macrophages in a concentration-dependent manner, suggesting it is an important nutrient during infection (PubMed:29531136).
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit, Ethanolamine ammonia-lyase beta subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment. Note=Probably located inside the BMC (Probable). Has been suggested to be on the BMC exterior.
Protein: RK14_TETOB
Sequence: MIQPQSYLNVADNSGARKLMCIRVLGGGRQTATIGDVIIAVVKDALPNMPLKKSDVVRAVIVRTSKGVRRENGMMLCFDDNAAVVINKEGNPRGTRVFGPIARELRDRNFTKIVSLAPEVV
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 1433Z_HUMAN
Sequence: MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396).  Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396).  Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396).  Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763).  In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
What are the official names of this protein?
14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.
Protein: RPOE_LEUMM
Sequence: MSLTTLGNHPKEEFALVEIATAILTEHKEAMPFSSLVQEIQEFLEVDAETFKSRLSQFYTDLNTDGSFISLGNNEWALRAWYPVDAIDESIHELDDEEDAPKRKKSAKKKVNVFADNASDDDVIDYNDDDPEDEDFGTVTDDDTETDDEETEVEVESDDESNEIDLSDDESIDANMTELSGGDDLDDLSDGDQEK
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: PYRH_FRATH
Sequence: MSNDSSECSQKLPKLKRILLKLSGESLSADQGFGINVESAQPIINQIKTLTNFGVELALVVGGGNILRGGRANFGNKIRRATADSMGMIATMINALALRDMLISEGVDAEVFSAKGVDGLLKVASAHEFNQELAKGRVLIFAGGTGNPFVTTDTTASLRAVEIGADALLKATTVNGVYDKDPNKYSDAKRFDKVTFSEVVSKELNVMDLGAFTQCRDFSIPIYVFDLTQPNALVDAVLDSKYGTWVTLD
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2060_FRASN
Sequence: MTAATLDLAIITGLSGAGRSTAAKCLEDLGWFVVDNLPPALLSTMAELGHRSGGAVSRIAVVVDVRGRAFFSDLRAAVEALDSRGMHPRMLFLEASDDALVRRFDHVRRPHPLQGDERVVDGINRERTLLAELRGEADLVLDTTDLNVHELRAKIDAAFGQPRANRLNATVISFGYKYGLPLDADLVADCRFLPNPHWVEALRPYTGRDSQVRDYVLAQPGATEFVDQYTALLRLVGEGYVREGKRYLTLAVGCTGGKHRSVAVAEQLGARLAADGVGVRVVHRDLGRE
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Franean1_2060.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: PQQE_GLUOX
Sequence: MTLPSPPMSLLAELTHRCPLSCPYCSNPLELERKAAELDTATWTAVLEQAAELGVLQVHFSGGEPMARPDLVELVSVARRLNLYSNLITSGVLLDEPKLEALDRAGLDHIQLSFQDVTEAGAERIGGLKGAQARKVAAARLIRASGIPMTLNFVVHRENVARIPEMFALARELGAGRVEIAHTQYYGWGLKNREALLPSRDQLEESTRAVEAERAKGGLSVDYVTPDYHADRPKPCMGGWGQRFVNVTPSGRVLPCHAAEIIPDVAFPNVQDVTLSEIWNISPLFNMFRGTDWMPEPCRSCERKERDWGGCRCQAMALTGNAANTDPVCSLSPYHDRVEQAVENNMQPESTLFYRRYT
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.