PharMolix/UniProtQA huggingface dataset:
Protein: HEMH_THEVO
Sequence: MKTAVLLLSYGSPEKMSDIDEYLSKIFGGKPVPKGVAEENYRKYEMFGGLSPSNRIIQSIRDRLQKRFDQSGDVDVFTAFKHWYPSIGEVVPDLKGYDNIVSIPLFSFFSENVKASYYKPLAEALEKNDIRTKMEFVNGISNYDLFIPMWIHLIEEKEKGDSFYLFDAHSLPHPENEEDYLFWLRYSTYKITQIMGLRSSDFGFQGGHEGWLGPSIYNVYRKAKEKKIIAVPISFLYDHLEILYDLDYEFRKKIEEDGYSYERVPMPNDSAIFITLLERIVSSSITHLSGELIGNGKEKSENFI
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFH1_RHOCA
Sequence: MGKLRQIAFYGKGGIGKSTTSQNTLAALVEMGQKILIVGCDPKADSTRLILNTKLQDTVLHLAAEAGSVEDLEVEDVVKIGYKGIKCTEAGGPEPGVGCAGRGVITAINFLEENGAYDDVDYVSYDVLGDVVCGGFAMPIRENKAQEIYIVMSGEMMALYAANNIAKGILKYANSGGVRLGGLICNERKTDRELELAEALAAKLGCKMIHFVPRNNVVQHAELRRETVIQYDPTCSQAQEYRELARKIHENSGKGVIPTPITMEELEEMLMDFGIMQSEEDREKQIAEMEAAMKA
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein 1, Nitrogenase Fe protein 1, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: KRE9_YEAST
Sequence: MRLQRNSIICALVFLVSFVLGDVNIVSPSSKATFSPSGGTVSVPVEWMDNGAYPSLSKISTFTFSLCTGPNNNIDCVAVLASKITPSELTQDDKVYSYTAEFASTLTGNGQYYIQVFAQVDGQGYTIHYTPRFQLTSMGGVTAYTYSATTEPTPQTSIQTTTTNNAQATTIDSRSFTVPYTKQTGTSRFAPMQMQPNTKVTATTWTRKFATSAVTYYSTFGSLPEQATTITPGWSYTISSGVNYATPASMPSDNGGWYKPSKRLSLSARKINMRKV
What is the function of this protein?
Involved in cell wall beta(1->6) glucan synthesis.
What are the official names of this protein?
Cell wall synthesis protein KRE9, Killer toxin resistant protein 9.
What is the protein family that this protein belongs to?
Belongs to the KRE9/KNH1 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RL27_BARBK
Sequence: MAHKKAGGSSRNGRDSESKRLGVKKFGGEAVIAGNIIIRQRGTRWHPGENVGIGKDHTLFSLANGTVSFRTKVNNRSYVSVIPAAVEAK
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PB2_PROTR
Sequence: AEYDVSDADIEAFYQXXTMTW
What is the function of this protein?
Possible mediator for cell division in the blooming process.
What are the official names of this protein?
Preblooming protein 2, PB2.
Protein: CCL3_RAT
Sequence: MKVSTAALAVLLCTMALWNEVFSAPYGADTPTACCFSYGRQIPRKFIADYFETSSLCSQPGVIFLTKRNRQICADPKETWVQEYITELELNA
What is the function of this protein?
Monokine with inflammatory and chemokinetic properties.  Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes.  Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx.  This protein binds heparin.
What are the official names of this protein?
C-C motif chemokine 3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, Small-inducible cytokine A3.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBL_PINPS
Sequence: DTDILAAFRVTPQPGVPPEEAGAADVTLGFVDLLRWSPELAAACEIWK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit, Water stress-responsive protein 1/2/14.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RBL1A_HYDCU
Sequence: MAKTYNAGVKEYRETYWMPEYEPKDSDFLACFKVIPQDGVPREEIAAAVAAESSTGTWTTVWTDLLTDLDYYKGRAYKIEDVPGDDAAFYAFIAYPIDLFEEGSVVSVMTSLVGNVFGFKALRACRLEDIRFPLAYVMTCGGPPHGIQVERDKMDKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVTSQPFMRWRDRFLFCQDAIEKAQAETGERKGHYLNCTAGTPEEMYERAEFAKEIGTPIIMHDYLTGGFTANTGLANYCRKNGLLLHIHRAMHGVIDRNPHHGIHFRVLTKALRLSGGDHLHSGTVVGKLEGDREATLGWIDLMRDSFIPEDRSRGIMFDQDFGAMPGVMPVASGGIHVWHMPALVSIFGDDSVLQFGGGTLGHPWGNAAGAAANRVALEACVQARNEGKEVEKEGKEILTNAAKHSPELKIAMETWKEIKFEFDTVDKLDVKHK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site (By similarity).  Can replace the endogenous type I ccbL gene in H. neapolitanus, constituting an active RuBisCO, however the active enzyme is not targeted to carboxysomes (PubMed:18974784).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain 1, RuBisCO large subunit 1, Non-carboxysomal form I RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_ACIB5
Sequence: MSNATKFGKVAVLLGGKSAERAVSLDSGQAVLDALLRSGVQAEAFDPQNRSVTELVNYDRAFIVLHGRGGEDGQIQGVLEWLNIPYTGTGVQGSAIGMDKVKTKQIWQGSDLPTAPYRIITKETDLDSVIAELGLPVIIKPVHEGSSVGMSKVEKAEDFAAAIEKATQHDAVVMAEKWITGREFTISFLNGQPLPVIRLQPPADVAFYDYEAKYQRNDVEYGIPCGLSETEEKKLQALCLRAFQAVGAEGWGRIDAMQDEQGNFWLLEVNTVPGMTSHSLVPKAAKAVGYSFDELCVAILDQTLEGTA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTNLG_ARATH
Sequence: MEEEKLEIVGPLEEPLMGNIVPEEINGLDSLTSSDSDSEKPDSPVPINAPIYRMFGRERPIHMVLGGGKPADVLLWRDKKVTLGLLSAVTVIWLLFGFGGRRLLTSLCRGSILFLLLSFLWSNALNKSPENMMDIYIPEKPLLQAASAMTFELNCAFATLRSIALERDIKNFVMAVIGLWLVSVIGNWFSFLSLLYICFVLIHTVPMLYEKYEDEIDPIAEKAVIEMKKHYQVFEAKFLSKIPH
What are the official names of this protein?
Reticulon-like protein B7, AtRTNLB7.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MOC2A_MOUSE
Sequence: MVPRCQIDVLYFAKSAEIAGVRSETISVPQEIKASELWKELEMLHPGLADVRNQVIFAVRQEYVELGDQQLLLQPGDEVAIIPPISGG
What is the function of this protein?
Acts as a sulfur carrier required for molybdopterin biosynthesis.  Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group.  In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3.  After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
What are the official names of this protein?
Molybdopterin synthase sulfur carrier subunit, Molybdenum cofactor synthesis protein 2 small subunit, Molybdenum cofactor synthesis protein 2A, MOCS2A, Sulfur carrier protein MOCS2A.
What is the protein family that this protein belongs to?
Belongs to the MoaD family. MOCS2A subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: FBH1_SCHPO
Sequence: MSAQHLHSCKFYRLPLEIIPLICRFLSVQDIQSFIRVFPSFQTILDSSNDLFWKKKNYELRIRRNRLLRGSYAAGVSSSAMNGFVNGTQISSTPAEREYYSKSDEIKNICGLPPGPMKVEQIGHAIDHLVSETHTVDHLGSSIKASFFHIDDVPLEWISSICMQVQSFFSPAAREAISSLKSRTTTSNLLLSLFVGILFEDDLWYFFNTLYMLSSTSAIEFAYFLDSIFTVVRTDYEHYRDPLSQTLITSCTRIHNIVAVIESPYDEPNTKGLTSEQKMIVECQLNPGEVLKVKAFAGTGKTKALLEFAKSRPKDKILYVAFNKAAKEDAELRFPFNVKCSTMHGLAYGAILAQADLPQAKLERQLSNSTIASLLSLQVAFPKANRKNNPGTPSASLVASHIMFTLNRFMHSTDWQLGFRHISKRSLEVTKLSKEKLLAYTKKLWSLIVNFEYTHAPLIPDAYMKLLHLYEFPNIFSKYDYILFDEAQDFTPCMVDLIYRQKHARIVIVGDAHQCIYGFRGANACAFNENLYPSTKQLCLTKSFRFGNSVAKYANFLLSLKGENVKLKGVQNDHAYWSSASNPNNVSGAFRFFPHTIIFRTNKELILQSIRLSVSLPKEIPIAILGSMRKKAFQLLRSGSELAHGQRPSHPKLKDFSSWGEFEVHVKNSAEEDAELALVYDMADELFSESFLSRLDNCEKRLMDSKDDGDNGIILATAHQSKGLEWDNVQLGNDFRPKFDSVSFSRIGSSRYLQEEINILYVALTRAKKRLILNDTITKLYALECGLVRFAGGILTEDQLQPGKVALFVDWQIDKFSFFYETPAEGYNLLVEANEKSVWDIFFGVLSGAWQNYIANTSERLKRSMLFIENQLFAVHDQ
What is the function of this protein?
Involved in ATP-dependent DNA-unwinding in a 3' to 5' direction, and ATP-ase activities stimulated by the single-stranded DNA-binding protein ssb1.  Essential for viability and normal growth of stationary phase cells and in the absence of either srs2 or rqh1 DNA helicase (PubMed:16135799, PubMed:9228070).  Involved in DNA recombination repair of strand breaks and stalled or collapsed replication forks, on the rhp51-dependent pathway: promotes rhp51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:16135800, PubMed:19546232).  Ubiquitination and DNA helicase activities are essential for controlling rhp51-dependent recombination in the absence of rad22.  Plays a role in the processing of toxic recombination intermediates.  Promotes proper chromosome segregation (PubMed:16135799, PubMed:16135800, PubMed:9228070, PubMed:19546232).
What are the official names of this protein?
F-box DNA helicase protein 1, DNA 3'-5' helicase 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Becomes localized at discrete nuclear foci together with rhp51, in response to DNA strand breakage.
Protein: COBS_METKA
Sequence: MIRVEFLKVFRFLTVLPIGEHPKSPREIGEQAWLGLPAVGLVSGLLAGVVAWAFAGTPVRGCLVVLTLLVLEGAQHFDGLVDVGDALMAGVISEEGATKAMRDPRVGVGGLAIGSMALLLAVASFGWIPFEVLVPIEVFSRFTVLPMAAVGEPAPASYSGRVFTEYVDADQVLLGGILSTVVSLPFSPVATLTCAVCSAVVAWTCLEAARRTIRGVNGDFLGASIWVSRVLSAVCLSSLPW
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PTAS_RICFE
Sequence: MKKQHIINETFLDAILAKKLGTTYTPPKEINDPDFDEAAKHFIDLLLRADGFKPVKTAVVHPIDKESLLGAVRAAQFNVIKPVLIGPQHKIESVAKVNNVDLEDYQVINVEHSHEAAKKAVELAKKREVAAIMKGSLHTDELMSAVVHKENGLRTERRISHAFLMAVATFPKPFIITDAAINIRPTLEDKRDIVQNAIDLMHMIKEDKQVRVAVLSAVETVTSAIPTTLDAAALSKMADRGQITSAIVDGPLAFDNAISLFAAEAKGISSSVSGNADILVVPDLESGNMLAKQLKYLGQAVMAGIVLGARVPIILTSRADPMDMRVISCVLASFIYNHTKAKLHIQAGK
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
Belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGDH_MOUSE
Sequence: MHVNGKVALVTGAAQGIGKAFAEALLLHGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFVQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEKEENMGQYIEYKDQIKAMMKFYGVLHPSTIANGLINLIEDDALNGAIMKITASKGIHFQDYDISPLLVKAPLTS
What is the function of this protein?
Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (By similarity) (PubMed:8950170).  Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression.  Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation.  Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (By similarity).
What are the official names of this protein?
15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-PGDH, Eicosanoid/docosanoid dehydrogenase [NAD(+)], Prostaglandin dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THYX_DESVH
Sequence: MPRTEPRVELLAHTPEPLSLLYAAFRQCYHAGFVADMWPRLLSGEIEREKQGAFIASILESGHSSPIEHVSFTFAIEGVSRALTHQLVRHRIASFSQQSQRYVDGSHFDYVMPPAIARNAAAKARFEQFMEDVGSAYRDIKALLEQDGRTGSRANEDARFVLPQAAASKIVVTMNCRALVHFFEERCCMRAQWEIRAVADVMLGLCREVLPELFAHAGAKCERLGYCPEGERFTCGRYPLRQSMP
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: PLYC_ASPTN
Sequence: MRLGIALFSLIGLCHSVSALIAFPGAEGFGANAVGGRQGEIYVVTNLNDSGEGSLRDAVSATDRIVVFAVGGVIEISDRIVVSKRVTILGQTAPGDGITVYGNGWSFSNADDAIVRYIRIRMGKVGDSGKDAITIAEGSTMIFDHVSVSWGRDETFSISGTASNITIQNTIIAQGLETHSCGGLIQTGGGVSLFRNLYIDNKTRNPKVKGVNDFTNNVVYNWGGGGGYIAGDSSGDSYANIIGNYFISGPSTSVTAFTRGNEYFHGYVETNYYDPDRDGTLNGNELGVSASNYGGMALVDTKYDYPAVEYQMTPGEAVNYVTGYVGASKVRDSVDTQLIAQVKSWGTKGELISDEASMGGPGDLDGGSPPTDSDGDGIPDDAETEIGSDPNTADSMELHSSGYTYVEMWANSLVPSSYH
What is the function of this protein?
Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.  Favors pectate, the anion, over pectin, the methyl ester (By similarity).
What are the official names of this protein?
Probable pectate lyase C.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: APAG_ECOK1
Sequence: MINSPRVCIQVQSVYIEAQSSPDNERYVFAYTVTIRNLGRAPVQLLGRYWLITNGNGRETEVQGEGVVGVQPLIAPGEEYQYTSGAIIETPLGTMQGHYEMIDENGVPFSIDIPVFRLAVPTLIH
What are the official names of this protein?
Protein ApaG.
Protein: SPTC2_HUMAN
Sequence: MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED
What is the function of this protein?
Serine palmitoyltransferase (SPT).  The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core.  The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference.  The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.  Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity).
What are the official names of this protein?
Serine palmitoyltransferase 2, Long chain base biosynthesis protein 2, LCB 2, Long chain base biosynthesis protein 2a, LCB2a, Serine-palmitoyl-CoA transferase 2, SPT 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RL361_CROS8
Sequence: MKVRASVKKLCRNCKIVKRDGVIRVICSAEPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: SYP_PSEP1
Sequence: MRTSQYLLATQKETPADAVVISHQLMLRAGMIRKLASGLYTWLPMGLRVMRKVEAVVREEMNAAGALEVLMPSIQPAELWQESGRWEQYGPELLRLKDRHQRDFCVGPTHEEVITDLARNELSSYKQLPLNLYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHADQASLQETYDRMHQAYSNVFTRLGLDFRPVQADTGSIGGSYSHEFHVLAESGEDDVIFSDSSDYAANIEKAEAIPRETVRPAPTEELRLVDTPNAKTIAQLVENHGLPIEKTVKTLIVRGAEEGKLIALIVRGDHELNEIKATKLEQVADPLVMATEAELRDAIGAGAGSLGPLNLPLEIIIDRSVALMSDFGIGANIDDKHYFGVNWERDLPVPQVADLRNVVEGDPSPDGQGTLVIKRGIEVGHIFQLGTKYSEALKCQVLGENGKPVVLSMGCYGIGVSRVVAAAIEQSYDDKGIIWNDALAPFQIALVPLRYETEVVREATDKLYAELTAAGFEVLLDDRDKKTSPGIKFADMELIGIPHRIVVSDRGLAEGNLEYKHRTEQDAQALPLNEVLTFLQARVRR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_CHLAB
Sequence: MIKNDTIAAIATPPGEGSIAIVRISGPEAIQITDKIFSGSVPSFSSHTAHLGTVSYNGQQIDQTLLLIMRAPRSFTGEDVVELQCHGGYFSCSQILAALIAEGARPALPGEFSQRAFLNGKIDLIQAEAIQNIIAADNLDAFHIAQNHFQGHFSKKVQQISSLIIESLAFIEVLADFPEEEQPDMQEPMNRLHEAILIIDDLIASFDQGQRLAQGTSIVLAGHPNAGKSSLLNALTNKNRAIVTDIPGTTRDILEENWMLQGKRIRLIDSAGQRETHNPIEQEGIERAIAAMEASEAILWVMDASQPPPPLPEILMRKPSLLLWNKSDLATPPHLETTLPQLAVSAKTGAGMIELKQFIQQWMQKQQLGKNGKVFLISSRHHTILQHMRTYLLSAQEGLQSQSPPEFIALELRQALQTTGNLSGSEINETILGEIFSRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECC_HAEIN
Sequence: MFIVYYSNQLEKQKEILSSLFKSLPPEDPFQQDIILVQSPNMAQWLQIELAKETGISANLKFPMPASFIWQLYAQNLPATALENPFDKDSMMWRLMRLIPIFLEKENFSPLRNYLSSSPHSEQYKLYQLSSKIADLFDQYLVYRPEWIFAWEKGEDEQITDQIQKQQPNLNATLFAQIQGNTKWQGELWRALVVDVKSDVNEATHRAALHNQFLALLADKKAPKKLPSRIFIFGIPALPTAYLNILQAISSEVDIHLFFNNPCQEYWGDISDLRLDYLRSRQRYQFNKQDENQPLFSEDQLSQLENAQFDVTYQKENLQLGNPLLAAWGKMGRDFLYILVRDEEHIPTYPVNAYQEIESNSLLGQLQSQILHLENKPLNIAKNDRTLTLHSCHSAMREVEVLHDYLLDLFNQDPSLTPKDVVVMVADINQYTPYIQAVFGQKNGDVPQIPFSLSDNKLSESDVLVSSYLTLLRLKESNFSAEDVLVLLDIPAMRERFNISLADLPLVREWVTDSGIRFGLQKNQDGINFNSWQAGLERMILGYAMREEQGIWQDSLGLNSSYGLKGELAGNLSHFFTALSALHETLQQAHSIEKWQEILTALLSDFFVRNEDTSDMIFYIQEKINELAEHLKTLHFNEELQAEVIADVITMQLEDAPNSLKFLAGKVNFCTLLPMRSVPFKVVCLLGMNDADYPRTQTPNSFDLMQYHYQKGDRVRRDDDRYLFLEALLAARDYCYISYVGRSITDNQPKEPSVLVSQLLDYINQGQKENVLTVIEHPMTAFSPDNFKNNEKFTRSFATKWLPIAQFDASSNNSEFAVTMTENLEKIEEVELDALVSFVENPVKFFFEKQLGVYFRDKDERIADSENFTLSGLDNYSLNNDLIYLDEQNFADYFRQAEVKGVLPRAEFGKVYAENIRDNVLEFKKKIADLGEAKHASVDFNLSVDWQNENQKIRLFGYMDALFGDDSQVIHWHFAKYKDRYCIRPWIYYLIQCVTQENAVPAKLITQDKVLELPPIEREVALAQLQIYVKDYLQSQIEIQLVPTVRNISDFIVSDENSVSEKLQELTESNGFGPKADPYWSRVLAQTSRFKQPENIAKLLKQTKAWFGLLFAQKKTRKTQS
What is the function of this protein?
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair.  Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity.  Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction.  Cuts ssDNA a few nucleotides 3' to the Chi site.  The properties and activities of the enzyme are changed at Chi.  The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair.  Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination.  In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
What are the official names of this protein?
RecBCD enzyme subunit RecC, Exonuclease V subunit RecC, ExoV subunit RecC, Helicase/nuclease RecBCD subunit RecC.
What is the protein family that this protein belongs to?
Belongs to the RecC family.
Protein: ACT24_DICDI
Sequence: MECKEDLTIVIDNGSGMCKAGFAGYDAPHAVFPSIVGRPRHTGVMVGMGQKDSYIGDEAQSKRDILNLKFPVERGIITNWNDMEEIWHHTFYNELRVAPEEHPVLLTEPPLNSKANREKMPQIMFETFNTPAMYVAIQAVLSLYASGRATGVILDSGDGVSYTVPVYEGNTFPLSITRLHLAGGDLTDYMSRLLYTDCGYYFSTKAEKEIVKDIKEKLAYVALDFEAEMQTAASSPSLEKSYKLPDGRMITIGNERFRCPEALFQPSLLAMDYDGIHETTYNSIMKCDVDFHKDLYGNVLLSGGSTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSAWIGGSILASLSSFQPRWISKEEYDESGPSIVHRKCW
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity).
What are the official names of this protein?
Putative actin-24.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RS8_SHESW
Sequence: MSMQDPIADMLTRIRNGQAANKVSVKMPSAKLKVAIAKLLKEEGYIADYAVADEAKPELEITLKYFQGQPVVETIQRVSRPGLRIYKGKNELPKVMGGLGVAIVSTSKGLMTDRAARLAGMGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.