PharMolix/UniProtQA huggingface dataset:
Protein: CNSE_PENEN
Sequence: MASETENLRAIALDPSHPTPTDVGEIYDETSDSLTDMLGGYIHVGYWEDPSKQETAEVVGDRLTREVGVRLSPAQGEHILDVGCGTGKSTAQLAGIYDAQVTGITISKQQVEVARSQYGRKMPAGQVHFQFADAMDLPFGDASFDGAYAIESLVHMLDKRTALAQIAQVLRPGSRLVIADLVSDHPCPDSPVLARYAEIFEPPLVSADDLQNLLRQAGFKVIDVTDIRENIRPSCKLFETKGLSLGGELGQKLLEIASILEEMNELGYALITAERL
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals (PubMed:25571861).  Communesins are biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks derived from L-tryptophan (PubMed:25571861).  The L-tryptophan decarboxylase cnsB converts L-tryptophan to tryptamine, whereas the tryptophan dimethylallyltransferase cnsF converts L-tryptophan to 4-dimethylallyl tryptophan which is further transformed to aurantioclavine by the aurantioclavine synthase cnsA, probably aided by the catalase cnsD (PubMed:25571861).  The cytochrome P450 monooxygenase cnsC catalyzes the heterodimeric coupling between the two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold (PubMed:26963294).  The O-methyltransferase cnsE then methylates the communesin scaffold to produce communesin K, the simplest characterized communesin that contains the heptacyclic core (PubMed:25571861).  The dioxygenase cnsJ converts communesin K into communesin I (PubMed:25571861).  Acylation to introduce the hexadienyl group at position N16 of communesin I by the acyltransferase cnsK leads to the production of communesin B.  The hexadienyl group is produced by the highly reducing polyketide synthase cnsI, before being hydrolytically removed from cnsI by the serine hydrolase cnsH, converted into hexadienyl-CoA by the CoA ligase cnsG, and then transferred to communesin I by cnsK (PubMed:25571861).  Surprisingly, cnsK may also be a promiscuous acyltransferase that can tolerate a range of acyl groups, including acetyl-, propionyl-, and butyryl-CoA, which lead to communesins A, G and H respectively (PubMed:25571861).  The roles of the alpha-ketoglutarate-dependent dioxygenases cnsM and cnsP have still to be determined (PubMed:25571861).
What are the official names of this protein?
O-methyltransferase cnsE, Communesin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: CYH3_MOUSE
Sequence: MDEGGGGEGGSVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDDFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFITMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
What is the function of this protein?
Promotes guanine-nucleotide exchange on ARF1.  Promotes the activation of ARF factors through replacement of GDP with GTP (PubMed:18042453).  Plays a role in the epithelial polarization (PubMed:20080746).
What are the official names of this protein?
Cytohesin-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3, CLM3, SEC7 homolog C, mSec7-3.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell junction, tight junction. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
Protein: IF1_XANCP
Sequence: MSKDDSIEFEGSVSETLPNTTFRVKLENGYEIIAHISGRMRKNYIRILTGDRVKVEMTPYDLTKGRITYRMK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_AERS4
Sequence: MPWIQIRINATAKTADKVSNMLLGRGAQPVTFMDAQDVPVYEPLPGETPLWGETEVMGLFDAETDPAPTIAFFQQIFGEDVGYKVEQLEDKDWVREWMDHFHPMQFGERLWICPSWRDVPNPDAVNVMLDPGLAFGTGTHPTTALCLQWLDGLDLAGKTVVDFGCGSGILGIAALKLGAARVIGIDIDPQAIQASHDNAERNGVAGQIELYLPADQPQDVEADVVVANILAGPLRELAPLIAGHGKPGSLMALSGVLESQAPELETIYGQWFDMDPTAVKEEWCRLSGRKHG
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGB_ECO45
Sequence: MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMELKVKTLRYFNELEAENIKGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: RL35_ALKCK
Sequence: MPKMKTHRGAAKRFKKTGTGKLKRSHAYTSHMFRHKSQKQKRKLRKAAIVHSGDFKRIHQMLTYKKK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: Y125_ELUMP
Sequence: MINNKKIFIITGLSGAGKTKALQIFGDFGFYCVDNLPLALFEHFVDHLKNRKEENIALGVDIREGKDLKTLPKIIANIKKADFHVYTIFLDASDSKLVQRFSETKHKHPIQKKLIAAIAQERKQLEPLRNIADKEIDTTNLTLGELKEKLSKVLVCNLKKDSEMQISVLSFGFKHGIPLEADLVVDVRFLPNPYYQPKLKEKTGLDSPVAKYIMSFPEANEFLIKYLNMLKFLIPKYMKEGKSYLTIAIGCTGGKHRSVFIANALTKALSQSGFTVSEYHRDIKK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Emin_0125.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: DAPD_YERPA
Sequence: MQQLQNVIETAFERRADITPANVDTVTREAITHVIDLLDTGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVMEGAETRYYDKVPMKFAGYDEARFQREGFRVVPPATVRKGAFIARNTVLMPSYVNIGAFVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFVGARSEVVEGVIVEEGSVISMGVFIGQSTRIYDRETGEVHYGRVPAGSVVVSGNLPSKDGSYSLYCAVIVKKVDAKTRSKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_SYNS3
Sequence: MSTLSRKQQTQKRHRRLRRHLSGTANRPRLAVFRSNSHIYAQLIDDEAQSTLCSASTLDKDLRSSLKTNCSSCDASVAVGDLVAKRAIAKGIQQVVFDRGGNLYHGRVKALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: Y4557_MYCA1
Sequence: MSTARTDDDSWEITESVGATALGVASARAAETRSENPLIKDPFAQVFLDAAGDGVWNWHSAPQLPPELIEAEPTIPLQQQAMVSYMASRTAFFDSFFLEATGAGIRQAVILAAGLDARSWRLPWPAGTTVYELDQPRVLEFKESTLAEHGAQPACNRVAVPVDLRHDWPEALRQAGFDASAPSVWSAEGLMPYLPAAAQDLLFDRIQGLTVAGSRVAVEALGPKFLDPQARAKRRERMDRIQALMARIDPDRAVPRTDELWYFEEREDVGEWFGRHGWDVRVTPSDELMAGYGRPAPAEVRDFVPGNLFVAAQRR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAV_4557.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: RL4_CLOK5
Sequence: MPIVGLFNKEGQKITDFELSDKVFGVEVNQYVMHQVVVALLANKRQGTQSAKTRAEVSGGGIKPWRQKGTGRARQGSIRSPQWIHGGVVFAVKPRSYRISVPKSARRLAMKSALSSKVEENQIVVLESLEMDTPKTKEVVKILDAFEAKKTLIVTAESNQNVYKSARNIQGVSVIPVNNLNVYDLLKFDKLIITKDAVSKIEEVYA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NAC_PYRFU
Sequence: MMPMNPKQLKKLMKQLDMRQLDNVVEVIIRLEDREIIIKNPTVTVIKAMGEKIYQIAGGEEEEKVKLVISEEDIKLVMEQTGVDYETAKKALEEANGDLAEAILKLTEGSP
What is the function of this protein?
Contacts the emerging nascent chain on the ribosome.
What are the official names of this protein?
Nascent polypeptide-associated complex protein.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: IL1RA_PIG
Sequence: MEVSRYLCSYLISFLLFLFHSETACHPLGKRPCRMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNTKLEEKIDVVPVEPHFVFLGIHGGKLCLSCVKSGDEMKLQLDAVNITDLRKNSEQDKRFTFIRSDSGPTTSFESAACPGWFLCTALEADQPVGLTNTPKAAVKVTKFYFQQDQ
What is the function of this protein?
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A.  Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
What are the official names of this protein?
Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, IL1 inhibitor.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NM111_PICST
Sequence: MSVPTKRRLSFDESTNKRFLNGTHSTENNTSNIEVDEDYGSDGSEQIFDLPATTNNNQWQETITKVVNAVVSIQFTHVSNFDTETSLVSEATGFVVDATRGLILTNRHVVGPGPFCGYVVFDNHEEAVVKPIYRDPVHDFGFLQFDPKEVKYLQLTQLELKPDLAKVGTEIRVVGNDAGEKLSILAGFISRLDRNAPEYGSLTYNDFNTEYIQAAASASGGSSGSPVVNEDGDVVALQAGGSTEASTDFFLPIYRPLRALQCIQKKQPITRGDIQVEWQLKPYDECRRLGLTPEAEARARKLFPNKIGLLVAELVLPQGQADGLIKEGDTLISIDDIDISTFIKVDEILDENVGNELKFVIQRGGEVITQMIKIGDLHSITPDRYVDVGGASFNNLSYQVARCYCIPVKGVFINDASGSFEFASYEKSGWLLETVDDMPTPDLDTLIEVMKMIPDCRRVPITYRHVSDLHTENIQIIYIERHWQSSFRLAVRNDTTGLWDFTDLQEKPLPPLSHEPQNAKFIDIPFSDETRSGCSSLVRSFVQVRLIAPVPMDSYPYRKEICYGVVVDSVNGYVLVSRRFVPHDMCDIFLIFAESIDVPAKVVFLHPNQNYAILKYDPSLVLADVKTPKFGDKPLKRGEKSYFIGYNYNLRLVTDDVKISGVSSLNIPPASLSPRYRGTNLECILLDSKISVECDSGVLADDDGTVRAFWITYLGEATCDQGSDRMYRMGLDVTDVLSVIEKLKVNEIPKQLRLLEAEFTSVTILQGRTRGVSQEWINKFEEVCEDEIKFLAVERVSAPTLHQEKNPLKAGDIILSVNDIIVKNMRDLKPMFTEQELKFRIIRQKKETEIVVPTIDTTTINTSHVVFWSGAIIQAPHYAVRQLMERVPSEVYVTRKSAGGPAHQYGIATNSFITHVNDVETKDLVSLMKVVKDIPDNTYIKLRLMSFDNVPIAISLKTNYHYFPTSELKKKEGSDEWIEIEHK
What is the function of this protein?
Nuclear serine protease which mediates apoptosis.
What are the official names of this protein?
Pro-apoptotic serine protease NMA111.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CRIS1_MACMU
Sequence: MEIKHLLFLVAAACLLPVLSMKRKSAKKLFNKLVTDLPNVQQEIVNIHNTLRRGVVPPASNMLKMSWSEEAAQNAKIFSRYCDMTESNPLERRLPNTFCGENRNMTSYPVSWSSVIGVWYSESKYFRYGLWPSTDDDISTDRYTQIVWATSYLIGCAIAPCRHRGSPRYFYVCHYCHEGNDPETKHEPYKKGVPCEACPNNCEDKLCTNPCIYYDEYTDCSLEVRFLGCNHSTPRMFCKATCLCDTEIK
What is the function of this protein?
May have a role in sperm-egg fusion and maturation.
What are the official names of this protein?
Cysteine-rich secretory protein 1, CRISP-1, Androgen-dependent acidic epididymal glycoprotein, AEG, mAEG.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head.
Protein: MNMA1_CALS4
Sequence: MEVNNRVVVGMSGGVDSSVTAYLLKEQGFEVIGVTMRVWVDPYGKARDDDKSCCSLKAIHDAKKVAEILGIPHYTVNLSEVFYDKIVKYFIDEYLKGRTPNPCVFCNRFIKFGDLLEKAHELGAYYIATGHYVRKEYDEDRKRYLLKKGLDFKKDQSYMLYRLTQEQLKHALFPLGNYTKEEVRALAEKIGLPVADKRESQEICFIPDNDYKAFIKRQIKKDVKPGEFRDIHGNFLGYHKGIINYTIGQRKGLGLSSDRPLYVVDIDPENNVVIVGHQEDVWGEELISSNNNFISIEKLEEEIKVTAKIRYTAKEDEAIIKPYGDDKVLVRFLRPQRAITPGQSVVFYDGDVVVGGGIIEKKVR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA 1.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPP_GIAIN
Sequence: MTLSAWIILVTLAMASVLTPEDNVRLRRLTAYVANADASIVLLTYTEYEEGTNHGNSMLWRINDPLEAEYPFDPDDISLLNAERVCPELVGVGDLQYSTHNQAFYFTAQGPDGTSQVYSYNHKLETCTQISFLPISVSNLKVSPKGNSVLFSAEIFVYPNNHASVDDPLNFAHDEFARIQARPYKAFAYEQLYTRHWDEDILPSQYRHLFAARLERSSEYDDDYVRITVDNSIDLMPRFDGDCPMRPFADASSYTFDSHGRYVAFVTQVGSTAAFYTNDSIWITDLQQFLDAKKPVRDVVLPLRCATCWNKARDQRPAFSYDGIFLYYASMDEEQSESDLLRLRKQNVSDLFEYDCDSLFCGPVTGEGVFNLTAGVFDRSIGQFIIPTDSTEDSIYILAEDHARTNLFRYNEESSTVTRLTYNGTLGSLLYLRHNKIFLATMSSYTRPTDLVMLDLTVATEFTATRDPSDTMKDDLIKISYLTDLNRQRLRHIDELQEPEEFYLPSKSFPDQYVHSWYFAPANLRDSHEYPLILYVHGGPESPWANSWSYRWNPQLIAARGYGVLATNFHGSSSFGEVFQKSVRGNWYSYPLEDIMDAWSNIYTHADKAYLSREKVCAMGASFGATFMNYMNSHVNNVTCYVTHDGVFDTMCNALETDELFFPVRELGGFLLDEQVDNQQLYEKWNPARFVENMSAPMLVIHGQKDYRIQVYHGISLFQALRLRGIKTKLVYFPTQSHWVWQPQESLFWHTQVFDWLDTYL
What is the function of this protein?
May be involved in metabolism of dipeptides or may affect host defense mechanisms.
What are the official names of this protein?
Dipeptidyl-peptidase 4, Dipeptidyl-aminopeptidase, Dipeptidylpeptidase IV, DPP IV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9C family.
What are the subcellular locations of this protein?
Membrane. Note=Associated with trophozoite membrane.
Protein: DNLJ_CHLPD
Sequence: MSDAVNVRKAIEELRREINRHNTLYYVDARPEISDYEFDRLMERLIELEKAFPDFVTPDSPSHRVGGAITREFPSVRHREPMLSLSNTYSLAEVEDFYSRVKKLLLVEGVREQDMAAELKFDGVAISLLYRDGLLVQGATRGDGTEGDDITTNLKTLSSVPLRIPLTSLPVIEGIERDIEIRGEVFMQKDDFARLNEARPEEDRFANPRNATAGTLKLQDSGEVARRRLNFVAYYLRLSSQDSFLLTQYDRLELLGQLGFFTGKHYRLCRDMKEIGDFIGYWAVERWNLPYETDGVVLKLNDVALWPRIGATAKSPRWAIAYKYPAQQAKTVLQGVAFQVGRLGTVTPVAELEPVRLAGSTVSRSTLHNFDEIERLGLMLHDRVIIEKSGEVIPKVIRVVLDERPENAEPVGVPSVCPECGASLEKPENEVSYYCPDQDSCPAQIRGRLLHFASRNALDIQSLGESLVAQLVQKGLVRDAGDLYLLQQPQLEALERMGRKSAHNLLRALQESREKSYERLLYALGIRHVGQATARELARAYETVEALQNASEEELATVPDVGPVVAHSVKDYFSKSSTQMLLRKLRDAGFPLRFTGPQKLINRNFEGVNVLFTGALERYGRQQASELVQQRGGRVVGSVSRSTGVVVAGSEPGSKLDKARKLGVKVISEDEFNAML
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ASTE_CITK8
Sequence: MDNFLAQTLAGISPDITQGETESFHWRWQMPGVLELTPAVEVDRALVLSAGIHGNETAPVEMLAALLSALFEGKIPLRWRLLVILGNPPALAEGVRYCHSDMNRMFGGRWQMFEESGETLRARELEQLLEDFYSRRKTRIRWHLDLHTAIRGSRHVRFGVLPQRSIPWDEHFLSWLGAAGLEALVFHQTPGGTFTHFSCEHFGALSCTLELGKALPFGHNDLTQFTPTAQALATLLAGEKPMEGGTRPIRYRVVAQITRRSDAFVLCMDNQTLNFTPFKKGTLLAQDGDEQVIVTHDVEYVLFPNPNVACGLRAGLMLEKLA
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: RIBL_HALSA
Sequence: MTRVVAQGTFDLIHPGHVHYLEDAAAMGDELHVILARRENVTHKDPPVLPNRQRRDVVAALDPVDHARIGHPEDIFAPIEAIDPDVIALGFDQHHDAAAIEAELADRGLDCAVERASPREARYDDEVLSSGDIADRVLAQRGDSDP
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.
Protein: RHMD_ECOLI
Sequence: MTLPKIKQVRAWFTGGATAEKGAGGGDYHDQGANHWIDDHIATPMSKYRDYEQSRQSFGINVLGTLVVEVEAENGQTGFAVSTAGEMGCFIVEKHLNRFIEGKCVSDIKLIHDQMLSATLYYSGSGGLVMNTISCVDLALWDLFGKVVGLPVYKLLGGAVRDEIQFYATGARPDLAKEMGFIGGKMPTHWGPHDGDAGIRKDAAMVADMREKCGEDFWLMLDCWMSQDVNYATKLAHACAPYNLKWIEECLPPQQYESYRELKRNAPVGMMVTSGEHHGTLQSFRTLSETGIDIMQPDVGWCGGLTTLVEIAAIAKSRGQLVVPHGSSVYSHHAVITFTNTPFSEFLMTSPDCSTMRPQFDPILLNEPVPVNGRIHKSVLDKPGFGVELNRDCNLKRPYSH
What is the function of this protein?
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).  Can also dehydrate L-lyxonate, L-mannonate and D-gulonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate.
What are the official names of this protein?
L-rhamnonate dehydratase, RhamD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
Protein: CARP8_CANAX
Sequence: MVSIITFTKNVLVTLAFALLAQGLAIPEDIDKRAEKVVSLDFTVTRKPFNATAHGQHHQSQQQQQQQQQQPAQKRGTVQTSLINEGPSYAATITVGSNKQQQTVIVDTGSSDLWVVDSAAVCQVTYPGQSPTFCKQDGTYKPSSSTTSQNLGKAFSIRYEDGSSSQGTVYKDTIGLGGASITNQQFADVTTTSVDQGILGIGFTGDESSPTYDNVPVTLKKQGIINKNAYSLYLNSASASSGTIIFGGVDNAKYTGSLTALPITSSNELRVQLSTINIAGTTVSASTTPVLDSGTTLTYFSQTIADKLAAAVGAKWNSYYQLYTSSCNLAGNIVFNFAKGVTISVPLSEFVLQDGNSCYFGVSRDSATILGDNFLRRAYAVYDLDGNTISLAQVKYTTSSSISTL
What are the official names of this protein?
Candidapepsin-8, ACP 8, Aspartate protease 8, Secreted aspartic protease 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARPC5_DICDI
Sequence: MNYEDDNVESGQAGKSDAEYKADIANREKEVTKALNAGKPQDALNVALADPPIYTKTGAIKDQNATIVLNLLGSFKDKDVETSVETLNDDQLDILMKYVYRGLATGENSPIFFKWHECVLKKGGAGTIIRVISEKKTV
What is the function of this protein?
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the pointed end of the daughter actin filament.  The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis.  In concert with a group of other proteins, the Arp2/3 complex plays a general role in the rapid activation and adaptation of the actin system to its multiple functions.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, p16-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, cell cortex. Cell projection, pseudopodium.
Protein: COXX_DECAR
Sequence: MQTIATPSLPLGQRLAAFSHLCKPRVNSLIVFTAMIGMCLATPDFPPLLRFGVASLGIALVSFAAAALNCLVERTVDAKMARTSWRATARGDISPLETVTLATALGAAGLWLLHGFINDLTMWLTLATFVGYTVIYTLILKPATPMNIVIGGASGAMPPLLGWTAMTGQVSAEPLVLFLIIFLWTPPHFWALACYRRDDYACSGLPMLPVTHGIAFTCQHILWYTLMLAAASLIPVSLGMSGGFYLIAIGLLDLVFLGYAIALCRRYSDALARRTFRYSILYLTLLFAALFADRLIVL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSM18_YEAST
Sequence: MQPIIKGAVSSTFKRALYNFGIKEKKSVNIEMGRTQQTKKIDQSLSKKLPKGTIYDPFDFSMGRIHLDRKYQANKNSNRNDIMKSGANPLEFYARPRILSRYVTSTGRIQHRDITGLSAKNQRRLSKAIRRCQAIGLM
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
37S ribosomal protein RSM18, mitochondrial, Mitochondrial small ribosomal subunit protein bS18m.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.
Protein: KI18B_CHICK
Sequence: MAMGPPPEDGTVAVVVRVRPPTPSERDGAAHPVLHVVDQHILVFDPEEPGGPPGAALPPRGPKHRGKDLKFVFDRVFGEGATQEEVFQHTTREVLDGVLNGYNCSVFAYGATGAGKTYTMLGSEQSPGIMYLTMAELYRRIEARRDEKSCEVLVSYQEVYNEQIHDLLEPKGPLAIREDPEKGVVVQGLSFHQPKSAEQLLEMLANGNKNRTQHPTDANATSSRSHAVFQIYVKQQDRVVGLSQDLQVAKMSLIDLAGSERASVTNTKGERLREGANINRSLLALINVINALADAKSKKTHIPYRDSKLTRLLKDSIGGNCRTIMIAAVSPSSLAYEDTYNTLKYANRAKEIKLSLKSNVLSLDCHISKYATICEQLKTEVADLQAKLRAYEDAARDAGKQIPALLPPPRMEEAVPESCSAPNVCRESDGEQQELGAGQDAQLGGEEEVLEEMPPSSPSPTQQTDLQLGMKKPNRLPQRLSRSHTEMLMATILSVAQKQYSLLKAANLLTPDMVSEFEELQLLVQKEAAVSPQPTDTSGAPPALRTQRGCDASPSTLSAEPSVPTTRAALRRLQQLTALSSPKLVAKKRRRSEMSNTSRLETPHSLNTRAKRQRKSSPLSAGGEVEAQRSPHTPCLKEPQSPPLLPCCTPKICPLTVTKRRAPLMTSAAQNCCTPTVCDLNVTYSLSEDVAKPGALSLPRFPGWENAPCALKKQEGPFVPRASIPVFSMKGSSIPKPSSISKGSVQKRRGAVSNASRSLGGIQSHITSSSSRRSAQPQSIPEHPPPGLTWKGRSGPR
What is the function of this protein?
May play an important role in microtubule plus-end depolymerizing activity in mitotic cells.
What are the official names of this protein?
Kinesin-like protein KIF18B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton.
Protein: RBS_PSEUX
Sequence: MRITQGTFSYLPDFTDEEITAQINYALTNDWPLSVEFTDDPHPRNTYWEMWGLPMFDLRDPAGVLMEVNACRAANPNAYVRLNAYDASLGRQTTALSFIVQRPAEEPGFRLDRAEGRGRAIGYTTHSYATERPVGDRYTQG
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
Protein: RS15_BRUC2
Sequence: MSITAERKQALIKEYATKEGDTGSPEVQVAVLSERIANLTEHFKGHKNDNHSRRGLLKLVSQRRRLLDYVKGVDHARYQALITRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.