PharMolix/UniProtQA huggingface dataset:
Protein: UPP_PYRAB
Sequence: MIEDKRWKGVYSFEDSPFIMEILTQLRDKNTDSIEFRKGLVKLGRYMGYELTKTMEVEKVKVETPLEETEGIIVKDRRNVVIITVLRAAIPLMEGLIKVFEHARVGIVSAVRGKAPEFKIEMDYVKIPQIKPEDTVIVADPMIATGSTLTRVLGEVKKYGEPKRTIVLGVLAAPEGISKIKSEFPDVEIFVAKIDRELDHKGYILPGLGDAGDRAFGEPLKLSTLPQVHHIE
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: VM2P2_PROMU
Sequence: MIQVLLVTICLAVFPYQGSSIILESGNVDDYEVVYPRRVSALPKGAVQPKYEDAMQYEFKVNGEAVVLHLEKNKGLFSEDYSETHYSPDGREITTYPSVEDHCYYHGRIHNDADSTASISACDGLKGYFKLQGETYLIEPLKLPDSEAHAVYKYENIEKEDEAPKMCGVTQNWESDESIKKASQLNLTPLQQRFLQRYVKLAIVVDYRMYIKYNRDSNKITVRAHEMVNHVNEMYKPLNITITLSLLQIWSQNDLITVQPASSITLRLFGNWRKTVLLNQQNHDNAQLLTDIVFNGRTIGKAPVAGMCQPDRSVGVVRDYSSNVFVVAVIMTHELGHNLGMEHDEDKNEKKCKCDTCIMAPAISDPPAQLFSDCSKNDYQLFLTVYNPQCILNAPLRTDTVSTPVSGNEFLEAGEECDCGSPENPCCDAATCKLRPGAQCAEGLCCDQCRFKKKRTICRRARGDNPDDRCTGQSADCPRNGLYG
What is the function of this protein?
Inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen.  Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
What are the official names of this protein?
Zinc metalloproteinase/disintegrin PMMP-2.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SSN3_CRYNB
Sequence: MATIPGGGTIMDPMHLYRARRDKERRGVLKTYKILGFISSGTYGRVYKAVLLPPPKTASAKSALPSSTRAALSLPKDKLPSPSFTEDSDPLNNPEMCMRPGDRPAKRGDVFAIKKFKPDKEGDVLTYAGISQSGAREIMLNRELHHRNLVSLREVILEDKSIYMVFEYAEHDFLQIIHYHSQTARASIPPSTLRRLLHQLLCGVHFLHSNFVLHRDLKPANILVTSQGVVKIGDLGLARLWHKPLAQQGLYGGDKVVVTIWYRAPELILGAKHYTAAVDIWAVGCIYAELLSLRPIFKGDEAKMDGKKSLPFQRDQMGKICEVLGPVKPEQWPGIVHMPEYRTYQATGPYPHSNPLAPWYHARSNSSEGYDILVKMFEWDPARRITARDALRHPWFQEEGGVDTKSVFEGSSITYPTRRVTHEDNGDAKMGSLPQSMAGGRLPSSSNFRPASGNIVQPAARKKARI
What is the function of this protein?
Component of the SRB8-11 complex.  The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase SSN3, Cyclin-dependent kinase 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARNF_PSEA8
Sequence: MNALRGWLAALGSMLLASAAQLGMRWGMSRLPLPEAWAGQTPERAALLAVALAVAAYAASLLCWLAALRHLPLGRAYSLLSASYALVYLLAASLPAFDETFSTSKILGVGLVVLGVLTVNARRTAAAPAHHPSRKAP
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EFGM_RAT
Sequence: MRLLRITAGLGRGPLPRVPAILGWQGKQANWKTYRWCSSGSIPNEKIRNIGISAHIDSGKTTLTERVLYYTGRIATMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTMWRDVNINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQTMTVSRQMKRYNVPFLTFINKLDRMGSNPARALQQMRSKLNHNAAFVQIPIGLEGDFKGIIDLIEERAIYFDGDFGQIVRYDEIPADLRAAAADHRQELIECVANSDEQLGELFLEEKIPSVSDLKLAIRRATLSRSFTPVFLGSALKNKGVQPLLDAVLEFLPNPSEVQNYALLNQNDSKEKNKILMNPKRDDSHPFVGLAFKLEAGRFGQLTYVRNYQGELKKGSTIYNTRTGKKVRVQRLVRMHADMMEDVEEVYAGDICALFGIDCASGDTFTNKDNSDLSMESIHVPDPVISVAMKPSNKNDLEKFSKGIARFTREDPTFKVHFDTESKETIVSGMGELHLEIYAQRMEREYGCPCITGKPKVAFRETVTAPVPFDFTHKKQSGGAGQYGKVIGVLEPLAPEDYTKLEFSDETFGANVPKQFVPAVEKGFLDACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALASATLCIIEPIMSVEVIAPNEFQGAVFAGINRRHGVITGQDGIEDYFTLYADVPLNNMFGYSTELRSCTEGKGEYTMEYNRYQPCSPSTQEELVNKYLEATGQLPVKKGKAKN
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.  Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PRMA_ERWT9
Sequence: MPWIQMKMNTSGAQAEELGDALIENGAVSVTFQDTHDNPVFEPLPGETRLWGDTDVIGLFDAETDMADVIAGLEHHPLLGSGFHHKIEQIEDKDWEREWMTNFHPMRFGQRLWICPSWRDVPDPNAVNVMLDPGLAFGTGTHPTTALCLTWLDGLDLAGKTIIDFGCGSGILAIAALKLGAAAAIGIDIDPQAIQASRDNAERNGVSDRLSLYLPHQQPDNLIADVVVANILAGPLRELAPLISVLPKRGGHLGLSGVLASQASGVCEAYADLFELDAVAEKEEWCRITGVRR
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMFB_MOUSE
Sequence: MSESLVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDERLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEWLREKLGFFH
What is the function of this protein?
This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
What are the official names of this protein?
Glia maturation factor beta, GMF-beta.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family. GMF subfamily.
Protein: RS10_STAEQ
Sequence: MAKQKIRIRLKAYDHRVIDQSAEKIVETAKRSGADVSGPIPLPTEKSVYTIIRAVHKYKDSREQFEQRTHKRLIDIVNPTPKTVDALMGLNLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DCUP_YERP3
Sequence: MNELKNDRYLRALLRQPVDMTPVWMMRQAGRYLPEYKATRAIAGDFMSLCKNAELACEVTMQPLRRYPLDAAILFSDILTIPDAMGLGLYFETGEGPRFQSPITCRADVEKLPIPDPEQELGYVMNAVRTIRRELAGSVPLIGFSGSPWTLATYMVEGGSSKAFTKLKKMMYAEPQTLHLLLDKLADSVILYLNAQIKAGAQSVMIFDTWGGVLTGRDYHEFSLNYMHKIVDGLIRENEGRRVPVTLFTKGGGQWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSVLYAPPARIEQEVSTILASFGQGEGHVFNLGHGIHQDVPPAHAGAFVNAVHALSRPYHQK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL1_HPV13
Sequence: MWRPSDNKLYVPPPAPVSKVITTDAYVTRTNIFYHASSSRLLAVGNPYFPIKKQNKTVVPKVSGYQFRVFKVVLPDPNKFALPDTSIFDSTSQRLVWACTGLEVGRGQPLGVGISGHPLLNKYDDVENSASYAANPGQDNRVNVAMDYKQTQLCLVGCAPPLGEHWGQGKQCTGVNVQPGDCPPLELISSVIQDGDMVDTGFGAMNFAELQSNKSDVPLDICTSTCKYPDYLQMAADPYGDRLFFYLRKEQMFARHFFNRAGSVGEQIPAELYVKGSNTLSNSIYYNTPSGSLVSSEAQLFNKPYWLQKAQGHNNGICWGNHLFVTVVDTTRSTNMTVCAATTSSLSDTYKATEYKQYMRHVEEFDLQFIFQLCTIKLTAEVMSYIHTMNPTILEDWNFGLSPPPNGTLEDTYRYVQSQAITCQKPTPDKEKQDPYAGLSFWEVNLKEKFSSELDQYPLGRKFLLQTGVQSRSPIRVGRKRAASTSTATPTTRKKAKRK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: ATPE_SYNS3
Sequence: MSLTLRVLAPDQSVFDGSADEVILPSTTGQVGILPGHVSLLAALDVGVLRVRTNSNWQSIALMGGFAEVESDDVTVLVNSAELGVNIDSTSAESDLSAARTAVTKLEGQPSTPEKVKAQQLFQRARARAQASKST
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: HEM6_PSE14
Sequence: MSTRTEAVKAYLLDLQDRICTALEQEDGNAHFVEDAWTRPAGGGGRTRVIENGAVIEKGGVNFSHVFGSNLPPSASAHRPELAGRGFEALGVSLVIHPHNPHVPTSHANVRFFIAEKEGEEPVWWFGGGFDLTPYYGVEEDCVHWHRVAERACAPFGDDVYPRYKAWCDSYFHLKHRDEPRGIGGLFFDDVNQWDFDTSFAFIRAIGDAFINAYLPIVRRRKAAAYTAQQREFQEFRRGRYVEFNLVYDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKAAPGSEEARLTEYFLTDRDWLADN
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_SALPC
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSNPASQIYVASKRKACDEVGFVSRSYDLPETTSEAELLALIDTLNADNTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKDLRHHVEHADLLIVAVGKPGFIPGEWIKEGAIVIDVGINRLENGKVVGDVVFDEAAARASYITPVPGGVGPMTVATLIENTLQACIEYHDPQGK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL16_CHLPM
Sequence: MLMPKRVKYRKTQRGRMKGNAGRGTDVSFGSFGLKAIEPAWITSRQIEAARVAMNRYMKRDGKIWIRIFPDKPVSKKAAETRMGSGKGAPEFWVAVVKPGRIMFEADGVSKEIATEAFRLAAKKLPIKTRFIVRPDYEG
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: NADB_HALH5
Sequence: MRCDGEVIIVGSGIAAMMSAYLLRKSFHVIMITKSDVFASNSFLAQGGIAAPIAEGDDWQAHTADTWKAGAAHGDETSIEMMTKHAVNMIELLDDLGVSFDREESGGYSLGLEGAHGTRRIVHVNGAETGKAVMRALWKAIKNEITLLDRTCVYRFIKNKDEIIGVETDQGSLFAPVTIVATGGCGQMYSVTSNGKEATGDGIALAYRSGAAISDVEFIQFHPTVYTGNEKEKGLLISEAVRGEGGQLITSAGERLQSLKSRDVVSREIFRQEREGHTVHLDLTGISDFERKFPALYKGFNKSDRRTLKPRVTPGAHFLNGGISVDAWGQTSLSRLYAVGEVACTGVHGANRLASNSLLEGLVFAHQAATHIQQTFQPLTAGLFVERDKAEPRSFKLPTREDLQKKMMRYVGIERHARSLWYMNNWFQPFLDTAHYNGPWPERDMFEQANMTLLASLITRSAAIRTESRGGHFRADYPNGLDKFQQLIIEWQNGAHMKRQRPTIKELSR
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
Protein: ADDB_STAS1
Sequence: MELNAYIGRAGTGKSKAIIEEIKEKMKQDPLGDPIVLIAPTQNTFQLEQAFVNDKTLNGSLRTEVLHFERLSYRVFQEVGGLMEQQLSKAGTEMMIYDIIQQHQSELRLYQSQVKYYGFSEKLYEQIQDFKKYAVSPQQLETYIAENNLQTRTKHKLQDIALVYKHLEDRINGEYVSTEDSLQRFIEMMDQSEWLKRAEIYIDGFHNFSTLEYQIIQSLVKYAKKVTIVLTTDGDRDLFSLFRKPSESLTHIEEIANNLNIQLHSRQFLDVQRFIHNDLKHLEQNFNALQFEPIPTEGNVEILEASGMREEINEVARRILRENREQGRRFQDIAILYRDESYAYLMESILPQYDIPYNIDVKSSMTHHPIMEMIRSLIEVIQTGWQFDPLMRLFKTNILTKKFKDSQYLIDILENFVLERGIYGKRWIDDKYFDIEQFRKMGLKRQPLTDEERETFERVIQLKNDVMKKVMLFEEKINNASTAIAFATAFYEAMEAFDLPSQLMTDRDTLDVNGEHKKAEEIDQIWNGLIQILDDLVTVFDDQSMSKTRFLELFDIGLEQLEFIMIPQTLDQVSIGTMDLAKVDNKQHVYLVGANDGVLPQTVTASSLITDEEKKYFQEQSSIELSPTADILQMDEAFVCYIAMTRSRAHVTFSYALMGASGDVKEPSPFLHQIQQLYTNLEVQNIHHQHQAEPLRLMEHPHQTKIALFESLKAWLDDELVAETWLDTYQVMRNDTRLNDGLTYLLSALTYDNQTVQLNPSLSKALYGSTINASVSRFEGYQACPFKHFASHGLRLNERTKYKLENFDLGDIFHRVLKFISEKVNGDFKNLNPKQIHKLTTEALSEILPEVQFNLLNSTAYYRYLSQRIGAIVETTLTALKYQGSHTKFTPQRFEASFRRKPKDQSELLATPLQTKQGIPINIRGQIDRIDTYQQGDESFVNIIDYKSSKYSGTLDLTKVYYGLQMQMMTYMDIVLQNKSRLGLTDMTKPGGLLYFHVHEPRIKLAWNQLSEDKRDTEFINSFKLSGLLNSATSVLDAFDTRLEPSYNSDIVPLGLKKDGGIKSNSKVADEQTIYKLIKHNKQNFIETASNIMDGHTEVAPMKYNQTLPCDFCNYKSVCHVDGMIDSKRYRTVDESINPLEAIQDVDLESEGE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB, DNA 3'-5' helicase AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: ACE_RAT
Sequence: MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPALDPGLQPGNFSADEAGAQLFADSYNSSAEVVMFQSTAASWAHDTNITEENARLQEEAALINQEFAEVWGKKAKELYESIWQNFTDQKLRRIIGSVQTLGPANLPLTQRLQYNSLLSNMSRIYSTGKVCFPNKTATCWSLDPELTNILASSRNYAKVLFAWEGWHDAVGIPLRPLYQDFTALSNEAYRQDGFSDTGAYWRSWYESPSFEESLEHLYHQVEPLYLNLHAFVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEEFFTSLGLSPMPPEFWAESMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVANDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVARNETHFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSTKAGAKLQQVLQAGCSRPWQEVLKDLVGSDALDASALMEYFQPVSQWLQEQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKNKEVSNHTLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVCYTNGTCLSLEPDLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSDAGDSWRSSYESDDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRAAGHTGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEWLVTENRRHGETLGWPEYTWTPNTARAEGSLPESSRVNFLGMYLEPQQARVGQWVLLFLGVALLVATVGLAHRLYNIHNHHSLRRPHRGPQFGSEVELRHS
What is the function of this protein?
Isoform produced by alternative promoter usage that is specifically expressed in spermatocytes and adult testis, and which is required for male fertility.  In contrast to somatic isoforms, only contains one catalytic domain.  Acts as a dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of substrates (By similarity).  The identity of substrates that are needed for male fertility is unknown.  May also have a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.  The GPIase activity was reported to be essential for the egg-binding ability of the sperm.  This activity is however unclear and has been challenged by other groups, suggesting that it may be indirect (By similarity).
What are the official names of this protein?
Angiotensin-converting enzyme, ACE, Dipeptidyl carboxypeptidase I, Kininase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase M2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Detected in both cell membrane and cytoplasm in neurons. SUBCELLULAR LOCATION: [Angiotensin-converting enzyme, soluble form]: Secreted. SUBCELLULAR LOCATION: [Isoform Testis-specific]: Cell membrane; Single-pass type I membrane protein. Secreted. Note=The testis-specific isoform can be cleaved before the transmembrane region, releasing a soluble form.
Protein: SYR_ACIF5
Sequence: MKAFVSQALQGALQQLHAQGRIPGIPATLELDRPKQVEHGHLASNVALLLAKAVGRKPRDIADDIVAALPASDWIARTEIAGPGFINFFLQPAAFHAVIHRVRTEKEHFGANRNGAGQRLQMEFVSANPTGPLHVGHGRGAAYGASLANILRFNGFDIFCEYYVNDAGRQMDILAASVYLRYLEADKALPWPFPENGYRGDYVREIAAHLREQVGDRLRHAAVGLPNLPQMSDGDIAIDTLIAHLKQSLGEDYRTLHSAGLDEILADIRDDLEGFGVHYERWYSEGSLMDTGAVDSAVAALEKAGHCYTQEGALWFRATAFDDDKDRVLRRDNGAYTYFASDVAYHAEKFARGFTHVIDMWGADHHGYVPRVKAALRALGLDDQQLEVVLVQFAILYRGTEKISMSTRAGEFVTLRELREEVGNDAARFFYVLRRADQHLDFDLELAKKHSEENPVFYIQYAHARVYSLLRQSVEKGLSLPPADGVGLEILQESREIALADALWRFPEVVATAARDREPHQIAFYLRELAAAFHTYYNSTRILVEETPLRHARLTLCLAVAQSIANGLRLLGVSAPEQM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3368_BACC4
Sequence: MLQALLIFVLQIIYVPILTIRTILLVKNQTRSAAGVGLLEGAIYIVSLGIVFQDLSNWMNIVAYVIGFSAGLLLGGYIENKLAIGYITYQVSLLDRCNELVDELRHSGFGVTVFEGEGINSIRYRLDIVAKRSREKELLEIINEIAPKAFMSSYEIRSFKGGYLTKAMKKRALMKKKDEHAS
What are the official names of this protein?
UPF0316 protein BCB4264_A3368.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BRPF1_MOUSE
Sequence: MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDSPPPPQQTPLRKHKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHSAPASAAPKLPEVVYRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEEEDEEEDEGKSWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQRNCEQVGRDSDDKNWALKEQLKSWQRLRHDLERARLLVELIRKREKLKRETIKIQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMGIDFETGMHIPHNLAGDEVSHHTEDVEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPSGRGNLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPKTAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMGSLRQRKRGRSPRPSSSSDSDSDKSTEDPPMDLPANGFSSGNQPVKKSFLVYRNDCNLPRSSSDSESSSSSSSSAASDRTSTTPSKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDEDSPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKVQGEQSSETSDSD
What is the function of this protein?
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (By similarity).  Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (By similarity).  Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640).  Positively regulates the transcription of RUNX1 and RUNX2 (By similarity).
What are the official names of this protein?
Peregrin, Bromodomain and PHD finger-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6. Localizes to transcription start sites.
Protein: PFKA_ENTFA
Sequence: MKRIGILTSGGDAPGMNAAIRAVVRKSIFDGIEVYGINYGFAGLVAGDIRRLDVADVGDKIQRGGTFLYSARYPEFATEEGQLKGIEQLKKFGIEGLVVIGGDGSYHGAMALTKRGFPAVGIPGTIDNDIPGTDFTIGFDTAINTVLESIDRIRDTATSHVRTFVIEVMGRNAGDIALWSGVAGGADEIIIPEHDFDMKNVAKRIQEGRDRGKKHCLIILAEGVMGGNEFADKLSEYGDFHTRVSILGHVVRGGSPSARDRVLASKFGSYAVELLKEGKGGLCIGMLDNQVVAADIIDTLENNKHKPDLSLYELNHEISF
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_STAAR
Sequence: MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKEGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10, Heat shock protein 10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.