PharMolix/UniProtQA huggingface dataset:
Protein: CAS9_CORDI
Sequence: MKYHVGIDVGTFSVGLAAIEVDDAGMPIKTLSLVSHIHDSGLDPDEIKSAVTRLASSGIARRTRRLYRRKRRRLQQLDKFIQRQGWPVIELEDYSDPLYPWKVRAELAASYIADEKERGEKLSVALRHIARHRGWRNPYAKVSSLYLPDGPSDAFKAIREEIKRASGQPVPETATVGQMVTLCELGTLKLRGEGGVLSARLQQSDYAREIQEICRMQEIGQELYRKIIDVVFAAESPKGSASSRVGKDPLQPGKNRALKASDAFQRYRIAALIGNLRVRVDGEKRILSVEEKNLVFDHLVNLTPKKEPEWVTIAEILGIDRGQLIGTATMTDDGERAGARPPTHDTNRSIVNSRIAPLVDWWKTASALEQHAMVKALSNAEVDDFDSPEGAKVQAFFADLDDDVHAKLDSLHLPVGRAAYSEDTLVRLTRRMLSDGVDLYTARLQEFGIEPSWTPPTPRIGEPVGNPAVDRVLKTVSRWLESATKTWGAPERVIIEHVREGFVTEKRAREMDGDMRRRAARNAKLFQEMQEKLNVQGKPSRADLWRYQSVQRQNCQCAYCGSPITFSNSEMDHIVPRAGQGSTNTRENLVAVCHRCNQSKGNTPFAIWAKNTSIEGVSVKEAVERTRHWVTDTGMRSTDFKKFTKAVVERFQRATMDEEIDARSMESVAWMANELRSRVAQHFASHGTTVRVYRGSLTAEARRASGISGKLKFFDGVGKSRLDRRHHAIDAAVIAFTSDYVAETLAVRSNLKQSQAHRQEAPQWREFTGKDAEHRAAWRVWCQKMEKLSALLTEDLRDDRVVVMSNVRLRLGNGSAHKETIGKLSKVKLSSQLSVSDIDKASSEALWCALTREPGFDPKEGLPANPERHIRVNGTHVYAGDNIGLFPVSAGSIALRGGYAELGSSFHHARVYKITSGKKPAFAMLRVYTIDLLPYRNQDLFSVELKPQTMSMRQAEKKLRDALATGNAEYLGWLVVDDELVVDTSKIATDQVKAVEAELGTIRRWRVDGFFSPSKLRLRPLQMSKEGIKKESAPELSKIIDRPGWLPAVNKLFSDGNVTVVRRDSLGRVRLESTAHLPVTWKVQ
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein.  The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA.  Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA) (PubMed:25830891).  Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs (PubMed:25830891).  PAM recognition is also required for catalytic activity (By similarity).
What are the official names of this protein?
CRISPR-associated endonuclease Cas9, SaCas9.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas9 family. Subtype II-C subfamily.
Protein: RIMM_NEIG1
Sequence: MTDTQNRVAMGYIKGVFGIKGWLKIAANTEYSDSLLDYPEWHLAKDGKTVSVTLEAGKVVNGELQVKFEGIDDRDSAFSLRGYTIEIPREAFAPTEEDEYYWADLVGMTVVNKDDTVLGKVSNLMETGANDVLMIDGEHGQILIPFVSQYIETVDTGSKTITADWGLDY
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRL44_ARATH
Sequence: MAGELISFGIQNLWNLLSQECELFQGVEDQVTELKRDLNMLSSFLKDANAKKHTSAVVKNCVEEIKEIIYDGEDTIETFVLEQNLGKTSGIKKSIRRLACIIPDRRRYALGIGGLSNRISKVIRDMQSFGVQQAIVDGGYKQPQGDKQREMRQKFSKDDDSDFVGLEANVKKLVGYLVDEANVQVVSITGMGGLGKTTLAKQVFNHEDVKHQFDGLSWVCVSQDFTRMNVWQKILRDLKPKEEEKKIMEMTQDTLQGELIRLLETSKSLIVLDDIWEKEDWELIKPIFPPTKGWKVLLTSRNESVAMRRNTSYINFKPECLTTEDSWTLFQRIALPMKDAAEFKIDEEKEELGKLMIKHCGGLPLAIRVLGGMLAEKYTSHDWRRLSENIGSHLVGGRTNFNDDNNNTCNNVLSLSFEELPSYLKHCFLYLAHFPEDYEIKVENLSYYWAAEGIFQPRHYDGETIRDVGDVYIEELVRRNMVISERDVKTSRFETCHLHDMMREVCLLKAKEENFLQITSSRPSTANLQSTVTSRRFVYQYPTTLHVEKDINNPKLRALVVVTLGSWNLAGSSFTRLELLRVLDLIEVKIKGGKLASCIGKLIHLRYLSLEYAEVTHIPYSLGNLKLLIYLNLASFGRSTFVPNVLMGMQELRYLALPSDMGRKTKLELSNLVKLETLENFSTENSSLEDLCGMVRLSTLNIKLIEETSLETLAASIGGLKYLEKLEIYDHGSEMRTKEAGIVFDFVHLKRLWLKLYMPRLSTEQHFPSHLTTLYLESCRLEEDPMPILEKLLQLKELELGFESFSGKKMVCSSGGFPQLQRLSLLKLEEWEDWKVEESSMPLLRTLDIQVCRKLKQLPDEHLPSHLTSISLFFCCLEKDPLPTLGRLVYLKELQLGFRTFSGRIMVCSGGGFPQLQKLSIYRLEEWEEWIVEQGSMPFLHTLYIDDCPKLKKLPDGLQFIYSLKNLKISERWKERLSEGGEEYYKVQHIPSVEFYHRVLHIFRSVGGDITGRLLMR
What is the function of this protein?
Potential disease resistance protein.
What are the official names of this protein?
Probable disease resistance protein RDL5.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
Protein: MAZE4_MYCTO
Sequence: MPFLVALSGIISGVHDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYESEAERSAARARRNARQQRSAQ
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Labile antitoxin that binds to cognate MazF4 toxin and counteracts its endoribonuclease activity.
What are the official names of this protein?
Probable antitoxin MazE4.
Protein: KEX1_FUSV7
Sequence: MAFLSIPSPRRWAALLSLSLGPILGAADATSNSAADYYVRDLPGLPKDGPNIKMHAGHIEVTPESHGNLFFWHFENQHIADKQRTVIWINGGPGCSSEDGAMMEIGPYRLKDKENLYYNNGSWGEFANLLFVDNPVGTGYSLVDTNAYVKELDEMADQFIQFLEKWFALFPQYDRDDIYIAGESYAGQHIPYIAKAILDRNKKNPSKAWNLQGLLIGNGWISPVDQYPAYISFAHEKGIIEKGSDNDKKLQSALRGCERVIASSPGRVDYGECEEILKNILELTRDGNKCINMYDVRLTDTYPSCGMNWPPDLEYLTPYLGRKDVVDALHVTSMKSTGWKECSGAVGGAFTARNSKPAVELLPDLLKEVPVLLFSGAEDFICNHLGTEELISKLEWNGGKGFEVTPGNWAPRRDWTFEGETAGFWQEARNLTYVLIYNSSHMVPFDLPRRSRDMLDRFMGVDISNIGGDPTDSRIDGEKGPETTVGGASNKTQSAAQDHQKQLDEAKWAAYQKSGEVVLVIVIIAAIAWGYFVWRERRKGAAYHALANHDNNSHSNGFRAKSQPGDLESAAFDESELDDLHGSTPATATSARFPVNRNDTREKFVTKYAEPSS
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: EUTC_RHOER
Sequence: MTEDQAPILDFWGPLRKTTQSRIGLGRAGDSLPTKRVLEFKAAHAAARDAVHEPLDSETLASRVDGVGIGAPVVVASSVSTRSEYLRRPDLGRQPADLSAIKSSDKEIGFILADGLSPRALMDHGEQLLSALVTALGERYSIAPPVIATNARVALGDHIAAAMGVQTAIVLIGERPGLSVADSVGIYLTHLPRVGRTDADRNCISNVHPPEGLGYEQAARVVLGLVTGARQLGRSGVDLKDTSRADAVASGEVLTLD
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds.  Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: HIS5_BORBR
Sequence: MSTIAIVDYGMGNFHSVARALQHAAPDADIRICNRPEQIDAADRVVFPGQGAMPDCMRTLNESGLRAAVERAAASKPLMGVCVGEQMLFERSEEGDTPCLGIFPGEVRRFAGPQFADPVAADQAAAAPPAAARERLKVPHMGWNQVRQTRSHALWEGIPDGTHFYFVHSYYAAPSDPALTTGVTDYGVAFTCAVAAANIFAVQFHPEKSAEHGLRLYRNFVDWQP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROL_ECO24
Sequence: MTQPLFLIGPRGCGKTTVGMALADSLNRRFVDTDQWLQSQLNMTVAEIVEREEWAGFRARETAALEAVTAPSTVIATGGGIILTEFNRHFMQNNGIVVYLCAPVSVLVNRLQAAPEEDLRPTLTGKPLSEEVQEVLEERDALYREVAHIIIDATNEPSQVISEIRSALAQTINC
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 2, SK 2.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family. AroL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_ACIBS
Sequence: MPRPITAVIHRQALQNNLAVVRKAMPNSKVFAVVKANAYGHGIERVYEAFKAADGFALLDLEEAKRIRALGWTGPILLLEGVFSPQDLFDCVQYQLSFTIHSEAQIEWVEQHPYPAQFDVFLKMNSGMSRLGFKPQHYVQAWERLNNLANVAKITHMMHFSDADGDRFGQQGIDYQITAFEEIVKDLPGERSVSNSAAILRYQDQLKSDYVRSGIMLYGSSPDYPTHSIADWGLQPTMSLRSEIISVQHLEPNESVGYGSNFVAEQPMTIGIVACGYADGYQRISPTGTPVLVDSVRTRTVGRVSMDMLAVDLTGIESAKVGSEVVLWGQSSTGVVLPIDDVAVSSGTVGYELMCAVTARVQFINQV
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: SYD_HAEIN
Sequence: MMRTHYCGALNRNNIGQDVTLSGWVHRRRDLGGLIFIDMRDRDGIVQVCFDPKYQDALTAAAGLRNEFCIQIKGEVIARPDNQINKNMATGEVEVLAKELRIYNASDVLPLDFNQNNTEEQRLKYRYLDLRRPEMAQRLKTRAKITSFVRRFMDDNGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFLTAPEVREIMERMVHGLWLDTIGVDLGKFPVMTWQEAMRRFGSDKPDLRNPLEMVDVADIVKDVEFKVFNEPANNPNGRVAVIRVPNGAEITRKQIDEYTQFVGIYGAKGLAWAKVNDINAGLEGVQSPIAKFLNEDVWKGLAERVNAQTGDILFFGADKWQTTTDAMGALRLKLGRDLGLTRLDEWQPLWVIDFPMFERDEEGNLAAMHHPFTSPKDFSPEQLEADPTSAVANAYDMVINGYEVGGGSVRIFDPKMQQTVFRILGIDEEQQREKFGFLLDALKFGTPPHAGLAFGLDRLTMLLTGTENIRDVIAFPKTTAAACLMTEAPSFANPQALEELAISVVKAE
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NA1C1_BUNCN
Sequence: GVACRCDSDGPTVRGNSLSGTLWLTGGCPSGWHNCRGSGPFIGYCCKK
What is the function of this protein?
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.  Thus it strongly stimulates mammalian cardiac muscle contraction.
What are the official names of this protein?
Delta-actitoxin-Bcg1a, Delta-AITX-Bcg1a, Cangitoxin, CGTX, CGX.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: LOLA_RALPJ
Sequence: MFVLNARHLMAAGLVSLAAWSAGAYAGAVEQLNAFVSNVSTARGEFVQRQVKGGTNGSPLRVAGTSNGDFVFSRPGRFVWRYVKPYEQQLSADGQMLYIFDKDLNQITERKLDASLGSSPAAILFGSNDLAKNFTLKEGGTKDGIDWVELTPKAKDTQFQRIAIGFRSGELQGMELRDAFGNTTLLTFSNIQKNPQLPANVFRFTPPKGADVIKQ
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CYC4_CLITE
Sequence: MASLRIAPLALFFFLAASVMFTVEKTEAGIPCGESCVFIPCITAAIGCSCKSKVCYRNHVIAAEAKTMDDHHLLCQSHEDCITKGTGNFCAPFPDQDIKYGWCFRAESEGFLLKDHLKMSITN
What is the function of this protein?
Probably participates in a plant defense mechanism (Probable).  Active against Gram-negative bacteria E. coli ATCC 700926 (MIC=1. 0 uM), K. pneumoniae ATTC 13883 (MIC=5. 5 uM) and P. aeruginosa ATCC 39018 (MIC=7. 5 uM) (PubMed:21596752).  Has hemolytic and cytotoxic activity (PubMed:21596752).
What are the official names of this protein?
Cliotide T4.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: PUR9_CAMJ8
Sequence: MRALLSVSDKEGIVEFGKELENLGFEILSTGGTFKLLKENGIKVIEVSDFTKSPELFEGRVKTLHPKIHGGILHKRSDENHIKQAKENEILGIDLVCVNLYPFKKTTIMSDDFDEIIENIDIGGPAMIRSAAKNYKDVMVLCDPLDYEKVIETLKKGQNDENFRLNLMIKAYEHTANYDAYIANYMNERFNGGFGASKFIVGQKVFDTKYGENPHQKGALYEFDAFFRANFKALKSEASFNNLTDINAALNLASSFDKAPAIAIVKHGNPCGFAIKENLVQSYIHALKCDSVSAYGGVVAINGTLDEALANKINEIYVEVIIAANVDEKALAVFEGKKRIKIFTQESPFLIRSFDKYDFKHIDGGFVYQNSDEVGEDELKNAKLMSQREASKEELKDLEIAMKIAAFTKSNNVVYVKNGAMVAIGMGMTSRIDAAKAAIAKAKEMGLDLQGCVLASEAFFPFRDSIDEASKVGVKAIVEPGGSIRDDEVVKAADEYGMALYFTGVRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: S12A7_RAT
Sequence: MPTNFTVVPVEARADGAGDEAAERTEEPGSPESADPACPTPGDGNPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEDSRRREIKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGASCDEYFVQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKMKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEAWKQADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTVATARTEAPPTPDKVQMTWTKEKLIAEKHRNKDTGTSGFKDLFSLKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS
What is the function of this protein?
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (By similarity).  May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear.  Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti.  May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
What are the official names of this protein?
Solute carrier family 12 member 7, Electroneutral potassium-chloride cotransporter 4, K-Cl cotransporter 4.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOB_OLIPU
Sequence: MLGDGKEGTSTIPGFNQIQFEGFYRFIDQGLIEELSKFPKIEDIDHEIEFQLFVETYQLVEPLIKERNAVYESLTYSSELYVSAGLIWKTSRNMQEQRIFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYQSELDHNGISVYTGTIISDWGGRLELEIDKKARIWARVSRKQKISILVLSSAMGSNLREILENVSYPEIFLSFLTDKEKKKIGSKENAILEFYQQFSCVGGDPIFSESLCKELQKKFFHQRCELGRIGRRNINWRLNLNIPQNNIFLLPRDILAAADHLIGMKFGMGTLDDMNHLKNKRIRSVADLLQDQLGLALARLENVVKGTISGAIRHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTANFRIRDIHPSHYGRICPIDTSEGINVGLIGSLSIHARIGDWGSLESPFYELFEKSKKARIRMLFLSPSQDEYYMIAAGNSLALNRGIQEEQAVPARYRQEFLTIAWEEVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVPAIAEHEGKILYTDTEKIVLSGSGDTLTIPLIMYQRSNKNTCMHQKPQVRRGKCIKKGQILADGAATVGGELALGKNILVAYMPWEGYNFEDAVLISECLVYGDIYTSFHIRKYEIQTHVTTQGPERITKEIPHLEGRLLRNLDKNGIVMLGSWVETGDILVGKLTPQVAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWVQKKGGSSYNPEIIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFECSLGLAGSLLDRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRIFDGRTGDPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPKPEDAPESFRLLVRELRSLALELNHFFVSEKNFQINRKEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SKP_ECO57
Sequence: MKKWLLAAGLGLALATSAQAADKIAIVNMGSLFQQVAQKTGVSNTLENEFKGRASELQRMETDLQAKMKKLQSMKAGSDRTKLEKDVMAQRQTFAQKAQAFEQDRARRSNEERGKLVTRIQTAVKSVANSQDIDLVVDANAVAYNSSDVKDITADVLKQVK
What is the function of this protein?
Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.
What are the official names of this protein?
Chaperone protein Skp.
What is the protein family that this protein belongs to?
Belongs to the Skp family.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y2359_NITWN
Sequence: MLNWVVTFLVIALIAGVLGFGGIAGASFEIAKIIFFIALILFVISAVVGFLRGRNRV
What are the official names of this protein?
UPF0391 membrane protein Nwi_2359.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSLU_THEYD
Sequence: MENLTPKKIVEELDKFIIGQESAKKAVAIALRNRFRRQLLPKELRDEILPKNILMIGPTGVGKTEIARRLARLVNAPFVKVEASKFTEVGYVGRDVESIIRDLTEVAMNMVKQEHTERVQEKARQLAEERVLDILLPQPRYTRDMNEAEERTRYKETREKLRKQLREGILDERYIEIDLKEKVVPFGIISNVAMEEIEINLKEMLGSFLPEKVKRKKVKIPEAIQLFTQEEANKLIDMEKVTKEAIERVEQTGIVFIDEIDKIASRGSSYGPDVSREGVQRDLLPIVEGSTVTTKYGPVKTDHILFIAAGAFHVAKPSDLIPELQGRFPIRVELNSLGKEEFVRILTEPDNALIKQYIALLATEDVYLEFTQDGIEEIADISQQVNEKTENIGARRLHTVMEKLLEDISFNASELKGQKITIDAKFVREKLSEIIKSEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP3_ROTHC
Sequence: MRVLGLFERGNNLNFADTYVYTWNQQYSYHENAFLISNQVATTIILYLDGININEVNKAFELLNSNGIPALIIKPDHIGIFTSSNFTYDWQYKIVYFHEYTYYKNNEFIVSDEFWLYTNINELLPYKILYYERGMRELYAGREYTLYNTATDDDILYKYIYEKDSIMNGTDYKKLYDTNSVKNFVHFMRLLRMRFAVPFDQLSNRITRSRVFSKSRIHIGLRNESIPQALDNIHSQWINYSANGIVISELKGLGSYSEKKISEFGIGQFKNYMNFLTLMFYIKNMKKKPSCTIIGAAPGYWISSMKKYFTIVTYDNKEVDSTEHHNRYFTDDDIVNVKTNGVYIDVRSEFKTNDWRQRRKLIEEETIKWLEISYKLLENKRVEAILLKMTAMDGEIPDGYCVHSPTTYRKSEYYLLIDKHIIKRQKIKVTKSLMYNAINTIYSDNVFISGKYSLRGKTEGVLALYCLSNTINQKEKVIQYANSFSGTCMTVRLNNTYEVDKIIDFKTNSDHTFLPSDFTCSLNTILTSYRGYAGIFGYAITKDLKSNGNNHIYIIPNARDENNFDTFGSHLGLSRYSHSKRFSESATTMSGYIFRDMVSGKENMQDTDKDNYASGHVFNAIAHYRFDYTYDIVGWLRLHKTGQFKVKSDIYKEHTDSEIRNAIESAYVYYLLDGDKVGEKYSKKMMEIWEVQV
What is the function of this protein?
Multifunctional enzyme involved in mRNA capping.  Catalyzes the formation of the 5' cap structure on the viral plus-strand transcripts.  Specifically binds to GTP and displays guanylyltransferase and methyltransferase activities.  Has affinity for ssRNA but not for dsRNA.  Capping activity is non-specific and caps RNAs that initiate with either a G or an A residue.  Together with VP1 polymerase, forms a VP1-VP3 complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are capped by VP3 and extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  DLPs probably have an RNA triphosphatase activity as well, whereas open cores do not.
What are the official names of this protein?
Protein VP3.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP3 family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. There are about 11 to 12 copies per virion.
Protein: COXX_BURMS
Sequence: MDTTLSHTPGSRLSQYLALTKPRVTQLAVFCAVIGMFLATPGMVPWKVLLGGTIGIGLLAGSAFAINCLVEQKIDAMMRRTAWRPSARGEITTLQILAFSTVLGGLGAWTLYTFTNPLTIWLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALGWAAVTGAVPGDAWILVLIIFVWTPPHFWVLALYRRKDYENAGLPMLPVTHGEQFTRLHILLYTVILFAVTMMPFISGMSGAVYLTSAVLLGALFLAYAWKIYRDYSDALARRAFRYSIVYLSLLFAALLVDHYARPVIGM
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RHLB_ECODH
Sequence: MSKTHLTEQKFSDFALHPKVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTSTFHYLLSHPAIADRKVNQPRALIMAPTRELAVQIHADAEPLAEATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMYDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEQMNNAEYIEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILDEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIPVSKYNPDALMTDLPKPLRLTRPRTGNGPRRTGAPRNRRRSG
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECEL1_MOUSE
Sequence: MEAPYSMTAHYDEFQEVKYVSRCGTGGARGTSLPPGFPRGSGRSASGSRSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPGAAGGGGACPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRDVSSAYNKVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSSWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW
What is the function of this protein?
May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
What are the official names of this protein?
Endothelin-converting enzyme-like 1, Damage-induced neuronal endopeptidase, Xce protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase M13 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.