PharMolix/UniProtQA huggingface dataset:
Protein: IF2P_HUMAN
Sequence: MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRDEMQKSDWQLIVELKKVFEII
What is the function of this protein?
Plays a role in translation initiation.  Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon.  GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome.  The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.
What are the official names of this protein?
Eukaryotic translation initiation factor 5B, eIF-5B, Translation initiation factor IF-2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL17_HCMVT
Sequence: MDHALFTHFVGRPRHCRLEMLILDEQVSKRSWDTTVYHRRRRHLPRRRAPCGPQRPAEIPKRRKKAAVLLFWHDLCWLFRRLFFPREDSEPLMSDPARSPEEEE
What are the official names of this protein?
Protein UL17.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL17 protein family.
Protein: CSPA_STRP1
Sequence: MAQGTVKWFNAEKGFGFISTENGQDVFAHFSAIQTNGFKTLEEGQKVAFDVEEGQRGPQAVNITKLA
What are the official names of this protein?
Major cold shock protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASNA_LACJO
Sequence: MTLILPKDYHPSLTIRDTEAAIVFIRENFQDKIADKLNLQRMSAPMFVEKSTGLNDNLNGIERPVAFDMKAMPDDTIEVVHSLAKWKRLALKRYGFGMHEGLYTNMNAIRRDEDLDNFHSIYVDQWDWEKIIAKEERNIETLKTTVKQIFKAIKETEKELSARYPGSTYRLPSDITFITTQELEDRWPDLAPEEREDKIAKEKKAVFLMKIGDKLKRSGKPHDGRAPDYDDWELNGDLLFWYEPLKRKIEISSMGIRVSEESLKEQLKKAHTEERSDLPFHKMLLEGKLPYTIGGGIGQSRLCMLLLGKAHIGEVQASIWPPEMIESCKAADIKIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EGL27_CAEEL
Sequence: MSRFDSQCSSEDVNKEDECVPSSSEDSQDGVSSPMENDDEPEFSQKHYDIEPCYYSLTGKSDRNCRGIVYRYRQDSDLKGFQSHDGTLYRLRDSVFVEVSQNEPYVIAAICGFKYTKRDHVVVKLTRYFRADDIPEISLNLMKQERAELEINPHLCPQSLNRELFNSELQITQPVSCLRGKCIVEYVKDVRHARTVADFSLDNDTFFFCLHYNQDSTKLASTHYAIRVGTSFQATLPPMAECSVGDDSDRDELLYRPNSIESGEEEDYIKLARCYRTYTLSGNHMLDSQKNARSLQVSDLLMDEAIIQLHRSGYKIDDALSELNANDIILTTDVDNMTQDDAKKFAKGIKQLGKNFSRIHRELLPHHSREQLVSYYYLWKKTPEATKPKQAARRVNPTSIKRPTKEKVKASRPTSTEYLDFDSASESDVENNGPSGRACHHCYGAESKDWHHANGLLLCTDCRLHYKKYGQLRQIANRPSQVPACLFKRSNSDEEESGVRTRAGKKEQRRRTPSSMSETPDRRSPSTVSNGAPNLTAEETPTKKLNGSVKRAPKRPLHNGVINNVEKSNSSEEPASPTTPPPTLTNGLTNGHGPESSTPNGETISKRMKVEPSYDDDDDEEEGKMTIDEGDDDPMPVLNGFKKEESVEEIKLELNGTIKKENGVETDPTTPTCSMEAENEVCETPAVVSVEIRDETNGETNSDLKDDENVEPDSPEDTFELGSNVEFETKNAMFVRSIVRSCGPRCARTDLIFKIKVGGVWEKSIKEKEERKKVHLQNQRIQDSEKVAIQQNQIKKEQQQSQPTPQQIHQQQAQQNAQHLQQLQQAVMLGHLPPEVLRQMMPPQFGVDPTAILMQQMMAGQQSQGVNAAFQHQMALQQQLEAHQVQFQLMMAHQHQQKMIAEQQQQQRHAAAQQLREREQREQRERERERQHQQQAQQALHQQQQQHAAAAANQLNPAMMQMMALMANSAASQQDIARLMEMAAQQQQQQQQAAQAQAQRDQERERREREAREREAAREREREQAAREAAARDQAAREHAQAVQAAAAAAQQAQALTPDMQHMHLLQQLMLNPALMMQLQQAQAQQQQQQPQVTNPLQMLQHGMAAQSANQAEMMRRIHPEPAMRPQHQ
What is the function of this protein?
Transcription factor which promotes stress survival and delays aging.  Required for cell cycle progression and development of the mesodermal and endodermal embryonic lineages (PubMed:25446273).  Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8.  Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development.
What are the official names of this protein?
Egg-laying defective protein 27.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPF_AGRFC
Sequence: MADTVEFAKMNGLANKILVVDMRGRKDMVTPAAAIALNSNPATQFDQIMAIHDPRVGGTDAFIDILNCDGTKAQACGNGTRCVVQALSSETGKTSFTFQTVAGILNAVEHEDGMISVDMGLPRFRWSDIPLSEEFHDTSRIELQIGPIDAPILHSPAVMSMGNPHAIFWVDRDPMTFDLERFGPLLENHPMFPEKANITLAQVISDSALRTRTWERGAGLTLACGSAACASAVSAARTGRTGRKVTIDVASSPVRVPLTIDWREDNHVVMTGPAEWEWSGSVDPVTGVWARDAVERGAV
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_MYCGI
Sequence: MSTYTPKAGDTTRSWYVIDATDVVLGRLAVEAAKLLRGKHKPTFTPNVDGGDFVIIINADKISLSGDKLTKKFAYSHSGYPGGLRKRAIGDLLAKHPTRVVENAITGMLPHTKLGRQIQKKLKVYAGPEHPHTAQQPVPFEIKQVAQ
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ARO1_YEAS7
Sequence: MVQLAKVPILGNDIIHVGYNIHDHLVETIIKHCPSSTYVICNDTNLSKVPYYQQLVLEFKASLPEGSRLLTYVVKPGETSKSRETKAQLEDYLLVEGCTRDTVMVAIGGGVIGDMIGFVASTFMRGVRVVQVPTSLLAMVDSSIGGKTAIDTPLGKNFIGAFWQPKFVLVDIKWLETLAKREFINGMAEVIKTACIWNADEFTRLESNASLFLNVVNGAKNVKVTNQLTNEIDEISNTDIEAMLDHTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVKEAELSRYFGILSPTQVARLSKILVAYGLPVSPDEKWFKELTLHKKTPLDILLKKMSIDKKNEGSKKKVVILESIGKCYGDSAQFVSDEDLRFILTDETLVYPFKDIPADQQKVVIPPGSKSISNRALILAALGEGQCKIKNLLHSDDTKHMLTAVHELKGATISWEDNGETVVVEGHGGSTLSACADPLYLGNAGTASRFLTSLAALVNSTPSQKYIVLTGNARMQQRPIAPLVDSLRANGTKIEYLNNEGSLPIKVYTDSVFKGGRIELAATVSSQYVSSILMCAPYAEEPVTLALVGGKPISKLYVDMTIKMMEKFGINVETSTTEPYTYYIPKGHYINPSEYVIESDASSATYPLAFAAMTGTTVTVPNIGFESLQGDARFARDVLKPMGCKITQTATSTTVSGPPVGTLKPLKHVDMEPMTDAFLTACVVAAISHDSDPNSANTTTIEGIANQRVKECNRILAMATELAKFGVKTTELPDGIQVHGLNSIKDLKVPSDSSGPVGVCTYDDHRVAMSFSLLAGMVNSQNERDEVATPVRILERHCTGKTWPGWWDVLHSELGAKLDGAEPLECTSKKNSKKSVVIIGMRAAGKTTISKWCASALGYKLVDLDELFEQQHNNQSVKQFVVENGWEKFREEETRIFKEVIQNYGDDGYVFSTGGGIVESAESRKALKDFASSGGYVLHLHRDIEETIVFLQSDPSRPAYVEEIREVWNRREGWYKECSNFSFFAPHCSAETEFQALRRSFSKYIATITGVREIEIPSGRSAFVCLTFDDLTEQTENLTPICYGCEAVEVRVDHLANYSADFVSKQLSILRKATDSIPIIFTVRTKKQGGNFPDEEFKTLRELYDIALKNGVEFLDLELTLPTDIQYEVINKRGNTKIIGSHHDFQGLYSWDDAEWENRFNQALTLDVDVVKFVGTAVNFEDNLRLEHFRDTHKNKPLIAVNMTSKGSISRVLNNVLTPVTSDLLPNSAAPGQLTVAQINKMYTSMGGIEPKELFVVGKPIGHSRSPILHNTGYEILGLPHKFDKFETESAQLVKEKLLDGNKNFGGAAVTIPLKLDIMQYMDELTDAAKIIGAVNTVIPLGNKKFKGDNTDWLGIRNALINNGVPEYVGHTAGLVIGAGGTSRAALYALHSLGCKKIFIINRTTSKLKPLIESLPSEFNIIGIESTKSIEEIKEHVGVAVSCVPADKPLDDELLSKLERFLVKGAHAAFVPTLLEAAYKPSVTPVMTISQDKYQWHVVPGSQMLVHQGVAQFEKWTGFKAPFKAIFDAVTKE
What is the function of this protein?
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
What are the official names of this protein?
Pentafunctional AROM polypeptide.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the shikimate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NS3A_CVCBG
Sequence: MDIVKSIDTSVDAVLDEFDCAHFAVTLKVEFKTGKLLVCIGFGDTILEAKDKAYAKLGCSIIEEVNSHTVV
What are the official names of this protein?
Non-structural protein 3a, ns3a, Accessory protein 3a.
Protein: F16PA_JANMA
Sequence: MKRISLTQYLIEEQRLHNNIPAELRLLLEVVARACKTISHAVGKGALGEVLGTAQSENVQGEVQKKLDIISNDILLEANEWGGHLAAMASEEMETIHQIPNRYPMGEYLLLFDPLDGSSNIDVNVSIGTIFSVLKAADGMQAPTEADFLQPGSKQVVAGYAVYGPQTVLVLTTGNGVQCFTLDREMGSWVMTQRDMQIPANTKEFAINASNARHWHPPVKRYVDEMLAGTTGPRAKDFNMRWIASMVADVHRILNRGGIFMYPADAREPDKPGKLRLMYEANPMAFIVEQAGGAATDGQQRILDIQPEKLHQRVPVFLGSKNEVELVTSYHKAK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_SHEB8
Sequence: MAIGLIGRKVGMTRIFTEDGVSIPVTVIEVAGNRVTQVKTLETDGYRALQVTTGTKKANRITKPEAGHFAKSGVEAGRGLWEMRLVDGEGEGIEVGAELNVDIFADVAKVDVTGQSKGKGFQGGVKRWNFRTQDMTHGNSLSHRSNGSIGQNQTPGRVFKGKKMSGHMGAERVTTQNLVVVRVDVERNLLLVRGAVPGATNGDLIIKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: MOSF_CLYJA
Sequence: DSDSAFLIG
What is the function of this protein?
Stimulates sperm respiration and motility.
What are the official names of this protein?
[Phe6]-mosact.
Protein: MPT51_MYCAV
Sequence: MTVVRGVSALLRVFCIAMLAAGLGVALQPAAVTGAARAAGYESLMVPSAAMGRDIPVAFLAGGPHA
What is the function of this protein?
May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.
What are the official names of this protein?
MPT51 antigen.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial A85 antigen family.
What are the subcellular locations of this protein?
Secreted.
Protein: NADD_TREPS
Sequence: MKLALFGGSYDPVHLGHLLLADAVHRHAGYDRVLFVPTFVSPFKEKEGSASAHDRVRMLHLAIGTTPYFSVEECEIRRGGISYTAETVQHVREKYGAQLEGKLALVLGEDAARSVPHWHAFDSWSTHVDFVVGARPVTSGDGGNVERATRTLQSFPFPWVSAENVALPISSTYIRTAIQRGRSWGYLVPSPVREYIIARGLYRS
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: CD68_HUMAN
Sequence: MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
What is the function of this protein?
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.  Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites.  Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
What are the official names of this protein?
Macrosialin, Gp110.
What is the protein family that this protein belongs to?
Belongs to the LAMP family.
What are the subcellular locations of this protein?
[Isoform Short]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Protein: CEA21_HUMAN
Sequence: MGPPSACPHRECIPWQGLLLTASLLTFWNAPTTAWLFIASAPFEVAEGENVHLSVVYLPENLYSYGWYKGKTVEPNQLIAAYVIDTHVRTPGPAYSGRETISPSGDLHFQNVTLEDTGYYNLQVTYRNSQIEQASHHLRVYESVAQPSIQASSTTVTEKGSVVLTCHTNNTGTSFQWIFNNQRLQVTKRMKLSWFNHVLTIDPIRQEDAGEYQCEVSNPVSSNRSDPLKLTVKSDDNTLGILIGVLVGSLLVAALVCFLLLRKTGRASDQSDFREQQPPASTPGHGPSDSSIS
What are the official names of this protein?
Carcinoembryonic antigen-related cell adhesion molecule 21.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. CEA family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: BBKI_BAUBA
Sequence: SVVVDTNGQPVSNGADAYYLVPVSHGHAGLALAKIGNEAEPRAVVLDPHHRPGLPVRFESPLRINIIKESYFLNIKFGPSSSDSGVWDVIQQDPIGLAVKVTDTKSLLGPFKVEKEGEGYKIVYYPERGQTGLDIGLVHRNDKYYLAVKDGEPCVFKIRKATDE
What is the function of this protein?
Inhibits bovine trypsin, human plasma kallikrein and plasmin and weakly bovine chymotrypsin.
What are the official names of this protein?
Kunitz-type serine protease inhibitor BbKI.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: XERC_ECO8A
Sequence: MTDLHTDVERYLRYLSVERQLSPITLLNYQRQLEAIINFASENGLQSWQQCDVTVVRNFAVRSRRKGLGAASLALRLSALRSFFDWLVSQNELKANPAKGVSAPKAPRHLPKNIDVDDMNRLLDIDINDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLESGEVWVMGKGSKERRLPIGRNAVAWIEHWLDLRDLFGSEDDALFLSKLGKRISARNVQKRFAEWGIKQGLNNHVHPHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates.  The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.  In the complex XerC specifically exchanges the top DNA strands.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_TRIEI
Sequence: MSISTSTLGYPRIGKNREVKKALESFWQQKISADELLKIVREIEEASWQTQTKAGIERIGIGDATLYDQILDWSFRFGIIPKRFQQFQNLECYFAMARGKDGILALEMTKWFDTNYHYLVPEITPDITPKADFSDFLETVKRAKKIIGKSAVPIIISPITFIRLSRLESVEFDNILAQLLPLYSDLLTKLKKLGISEIQLHEPALVFGDSSNLKKQFEMAYAELAKVGLNIHLVTYFDDLGETYPWVMKLPVTSISLDLTRGQNLELIKSYGFPADKTLGAGVVDARNIWRIRTQEVTSLLEELKGIIPNISVQPSASLQFVPYDVRREVKLPEALRNVLSFAEQKLEETVLLSKALTGKSNKSEIENIEIYWQEFYKFSPANEKVKSQIKALKETDFRRSMSYLERLDNQIKLPAFPTTTIGSFPQTKQVRKLRARYKKGELTQAEYLAQIDANIAYCIGLQEGMGMDVLVHGEFERSDMVEYFGEQLDGYTFTTHGWVQSYGSRYVRPPIIFGDIYRPHAMTIREFEVAQSLTEKPVKGMLTGPVTMLNWSYPRTDISRQEQAFQLALAIREELKDLEKAGAAFIQVDEPAMREGLPLKQQRWHEYLNWAVDAFRLSTAIARPETQVHTHMCYSEFGDIMESIKQLDADVISIEDSRSNNETLMQLTDADYPAQVGPGVYDVHSPSIPTTEYLRESLYKCIQYLPVTQIWVNPDCGLKTRRWEEAIPATRNMVQAAISLRQE
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: RS20_SHEWM
Sequence: MANSKSAKKRALQSEKRRQHNASRRSMLRSYVKKVIAAIQAGDHAAATEAFNAAQPILDRMATKGLIHKNKAARHKARLNTRIKALAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: AATF_HUMAN
Sequence: MAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDEGEDGEGDFLVVGSIRKLASASLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEEGSGDEDSEGLGLEEYDEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGMEEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPLFKDKGGPEFSSALKNSHKALKALLRSLVGLQEELLFQYPDTRYLVDGTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFTVYRNRTLQKWHDKTKLASGKLGKGFGAFERSILTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPESLPGEPEILPQAPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDARTELYRSLFGQLHPPDEGHGD
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).  May function as a general inhibitor of the histone deacetylase HDAC1.  Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression.  Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression.  Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
What are the official names of this protein?
Protein AATF, Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1.
What is the protein family that this protein belongs to?
Belongs to the AATF family.
Protein: PTCB_LACLM
Sequence: MADKVIALACAAGMSTSLLVSKMQKAAAENGKDYEIFAKSTADIDNMLAGTGSPKPDVLLLGPQVAFMKGEVAKKAEIAGVPMDVIKMQDYGMMRGDKVLAAAENLMN
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity).  Involved in galactose transport with PtcA and Lmg_0963 (PubMed:30123211).
What are the official names of this protein?
PTS system galactose-specific EIIB component, Galactose-specific phosphotransferase enzyme IIB component.
Protein: PDXS_METKA
Sequence: MKTGTWRVKTGFARMLKGGVVMDVTNVEQAQIAEDAGAVAVMVLEKVPADIRAAGGVARMCDPAKIEEIMDHVTIPVMAKCRIGHVAEAQVLEAIGVDMIDESEVLTPADEEHHINKWEFEVPFVCGARNLGEALRRIAEGAAMIRTKGEAGTGNVAEAVRHMRIIRREISELTRLDKEELYGKAKEYGVPFDLVAEVASLGRLPVVNFAAGGIATPADAALMMQLGADGIFVGSGIFKSDRPQEMAEAIVEATAYYDDPEVVAEVSKNLGDEVAMRGLEISEIPEEERMQLRGE
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: UBIE_PSEAB
Sequence: MNDPRKGADAEPTTHFGYQNVPESQKAKKVAEVFHSVAAKYDLMNDLMSGGIHRLWKRFTIELSGVRSGNRVLDIAGGTGDLTRQFSRLVGPTGEVVLADINASMLKVGRDKLLDKGVSGNVSFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKDEAIRSMLRVLKPGGRLLVLEFSKPSSNLLSKAYDAYSFSLLPLMGKLVTNDSESYRYLAESIRMHPDQETLKAMMVEAGFDRVTYHNMTGGIVALHRGIKP
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: VKGC_HUMAN
Sequence: MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF
What is the function of this protein?
Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
What are the official names of this protein?
Vitamin K-dependent gamma-carboxylase, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase.
What is the protein family that this protein belongs to?
Belongs to the vitamin K-dependent gamma-carboxylase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HPYO_XANCP
Sequence: MSLAQLEHALQHDLQRLAHGGEPWVRPRVHPAGHVYDVVIVGAGQSGLGAAFALQRERVHNVLVIDENPPGQEGPWVTYARMQTLRTPKQITSIDLGVPTLTFRAWWEAQHGAAGWDALDKIPRGTWMDYLRWYRAALRLPVRNATQLVRIEPDAAPGIHRLHLAMGAPLMARKIILATGIQGGGQWQVPEWITQALPAQRYAHTSGPIDYAALAGKRVGILGGGASAFDNACFALDQGVARAEVFVRRAALPRVNPIRHMEQAGIIPRFAALPDADKYRMMASFFGRNQPPTNDTFQRACAHAGFALHLDAPWLGVEEHNDVVVVRTPQGEHRFDFLAIATGLVTDPRLRPELAALSGRIACWADRYQAPPGQANPVLDAHPYLGPGFELLPRTPDDAAAVDGLFAFNYSALINHGLSAAALSGLKVALPRLARAVADQLFLDDRQAMVEAYLGYDQAEFVGQWPQPTQAVA
What is the function of this protein?
Catalyzes the hydroxylation of urate to 5-hydroxyisourate (HIU).  Is likely to be involved in the urate degradation pathway to allantoin.  Is slightly more efficient (about 2. 6 times) with NADPH than NADH as the electron donor.
What are the official names of this protein?
FAD-dependent urate hydroxylase, Flavoprotein urate hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the HpyO family.