PharMolix/UniProtQA huggingface dataset:
Protein: GATB_METFK
Sequence: MSWEVVIGLETHVQLNTRSKIFSGSSTAFGAEPNTQANVVDVALPGVLPVLNKEAVQCAIRFGLAVNAEIAPRSVFARKNYFYPDLPKGYQISQYELPVVGKGALTIQVGDTEKTIRITRAHLEEDAGKSMHGASPGQSGIDLNRAGTPLLEIVTEPDMRSAAEAVAYARKLHELVQWINICDGNMQEGSFRCDVNVSVRRKGQEKLGTRREIKNLNSFRFMQQAIEFETRWQIETLEDGGKIEQATVLFNPDTGETRAMRTKEEANDYRYFPDPDLLPLAISTEDIDAVRVTLPELPSAMKARFERDYGLSAYDASALTASRSVADYFTATLAEFGGEAKLVANWVMGGISAKLNEEGREITDAPVSPVLLAGLLKRIADNTISSKIAKDVFEAMWAGEGDADAIIERKGLKQVTDSGAIEAIVDEVLAANAAMVEEFRAGKEKAFNALVGQTMKASKGKANPAQVNEILKRKLAG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RSMH_HELMI
Sequence: MVFHHIPVLLHQVLEVLKPRPEGVYLDGTVGGGGHSAAILQKLSGRGRVIGLDQDPAALAAAGRKLASFGDRVTLVRSNFRHIGAVVAELGLTGKIDGILLDIGVSSHQLDEAERGFTYRMDAPLDMRMNPESALTASKLLNEAPEGEIARILRDYGEERWAKRIAQFIVKRRALQPLERTGELVDIIRAAIPAAARQEGGHPAKRTFQALRIAVNDELGALEEALPAALEALAPGGRLAVISFHSLEDRIVKSFFAEQARGCLCPPDFPVCACGNRPKVKIITKKPLVGSDEEMRANPRAQSAKLRAAEKIR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXC_BRUSI
Sequence: MNAYQKTIGRAVTLSGVGVHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGATDLCTSLGAREARIDTVEHLMAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGVVTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEIDFECPLIGRQKFAHDVDEETFRKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTLDAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: RUVB_ECO57
Sequence: MIEADRLISAGTTLPEDVADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATTRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SWNN_ARTBC
Sequence: MAVVAVAGGTGGKGVPGAANEPRRYAVDYDNVEEMRNVLKENNVEVVVSALLLSDESVAKSQINLIRAAAESGTVTKFIPSEYYIDFHSPIPGSDLFTNFQIEAEEELMRHPQLTWTLIRVGIFLDHLTMPFNPKPTYITPYWVFVDIEHEECVFPGDGSQPLVLSHSTDLAAYIECLVGLPSNEWPRESLVASNKIQVKDLQDLIKKTTGTLCGHLGICIRTFLILAIGREFKVTYDSVESIQKGQITPLTSNRPVFDDPQKGKLFQEVEVQVMLSMLSNAHDLPGKNLAELFPEVHVTNIEDFLRAGWEMKQGLKP
What is the function of this protein?
Aminotransferase; part of the gene cluster that mediates the biosynthesis of swainsonine (SW), a cytotoxic fungal alkaloid and a potential cancer therapy drug (PubMed:28381497).  Swainsonine production occurs via a multibranched pathway and is dispensable for fungal colonization of plants and infection of insect hosts (By similarity).  The first step of swainsonine biosynthesis is the production of the precursor pipecolic acid (PA) via conversion of L-lysine (Lys) to 1-piperideine-6-carboxylate (P6C) by the aminotransferase swnA, the latter being further reduced to PA by the reductase swnR (By similarity).  The PKS-NRPS hybrid synthetase swnK uptakes and condensates PA and malonyl-CoA with and without skipping of the ketoreductase (KR) domain in order to produce 3 intermediates, 1-oxoindolizidine, (1S)-1-hydroxyindolizin, and (1R)-1-hydroxyindolizine; with the transisomer (1S)-1-hydroxyindolizin being predominant (By similarity).  The terminal thioester reductase (TE) domain of swnK is involved in reduction of the thioester bond to release the intermediate aldehydes (By similarity).  The oxidoreductase swnN could contribute to the reduction of 1-oxoindolizidine to (1S)-1-hydroxyindolizin and (1R)-1-hydroxyindolizine, contributing to the major route of SW production (By similarity).  The dioxygenase swnH2 would be responsible for the oxidization of (1R)-1-hydroxyindolizine into (1R,2S)-1,2-dihydroxyindolizine and of (1S)-1-hydroxyindolizin to yield both (1R,2S)-1,2-dihydroxyindolizine and (1S,2S)-1,2-dihydroxyindolizine (By similarity).  The dioxygenase swnH1 then performs the conversion of the 1,2-dihydroxyindolizine epimers to SW (By similarity).
What are the official names of this protein?
Oxidoreductase swnN, Swainsonine biosynthesis gene cluster protein N.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: SSN8_COCIM
Sequence: MAADYWSSTQHQSWLFGREELAEARKVLGDAERPFIQQYPLPDLRLFNIYVNQQLIKLAKRLNVRQQALATAQVYVKRFYTKVEIRRTNPYLVLTTAFYLACKIEECPQHIRLVLGEARGLWPEFIAPDSAKIGECEFWLISEMNSQLIVHHPYRTLSELQSYLSLTSDEIALAWSVINDHYLTDLLLLHPPHVISVMAIFIAVVFKPNQHQVVSISGGSSATGALRDGSTNILSAFNDKTGAGMPAKVQRIVDWLANSDINIEAVIECTQDIVSLYEVWEQYSEKVCKEQIGRYVKSRGLDK
What is the function of this protein?
Component of the SRB8-11 complex.  The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
RNA polymerase II holoenzyme cyclin-like subunit.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: FETP_LARHH
Sequence: MARMVQCIKLGREAEGLDFPPLPGELGKKVYENVSKEAWQAWLRHQTMLINENRLNLADSRARQYLTQQLQNYFFGTGADMPAGFVPPSV
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: DEOC_THET8
Sequence: MDLAAHIDHTLLKPTATLEEVAKAAEEALEYGFYGLCIPPSYVAWVRARYPHAPFRLVTVVGFPLGYQEKEVKALEAALACARGADEVDMVLHLGRAKAGDLDYLEAEVRAVREAVPQAVLKVILETGYFSPEEIARLAEAAIRGGADFLKTSTGFGPRGASLEDVALLVRVAQGRAQVKAAGGIRDRETALRMLKAGASRLGTSSGVALVAGEGGTLGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR2_BACCZ
Sequence: MNSLEQVKGLIKEEIQAAVLKAELATEEQIPNVVLESPKDKTNGDFSTNMAMQLARVAKKAPRMIAEELVANFDKAKASIEKIEIAGPGFINFYMDNSYLTDLIPTIVNAGEAYGETNTGKGEKVQVEFVSANPTGDLHLGHARGAAVGDTLCNLLAKAGYDVSREYYINDAGNQIHNLALSVEARYMQALGLEKEMPEDGYHGADIIGIGKRLAEEFGDRYAKADEKESYEFYREYGLKYELAKLQKDLESFRVKFDVWFSETSLYKNGKIDQALAVLKERDEIFEEDGATWFRSMTYGDDKNRVLIKNDGSYTYLTPDIAYHRDKLERGFDKLINIWGADHHGYIPRMKAAIQALGYDKETLEVEIIQMVQLYQNGEKMKMSKRTGKAVTLRELMEEVGVDAMRYFFAMRSGDSHLDFDMDLAVSKSNENPVYYAQYAHARVCSILRQGEELGLATGGDVNYKLVTSEKEVELLKKLGEFPAVVADAAQKRLPHRITNYAFELAATLHSFYNAEKVLNQDNLELSKARYELMKAVRTTLQNALAIVGVSAPEKM
What are the official names of this protein?
Arginine--tRNA ligase 2, Arginyl-tRNA synthetase 2, ArgRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSHD_CLAM3
Sequence: MSAFPPPPIPAPDASRVARVEPTPDVVRGILELGDRARADDGVAPFNEQTRLLLGTEDGPALLVVQGTDGRPIGAAVAARGDGGIEAEIVVDPARRRRGVGRALLDAVLAEAAGSPVSVWAHGDHPGARALAAATGLDRARELLQLRASVAEARTGLGERPMPAGLALSSFTADDADDWVALNARAFASHPEQGRMTRGDLDDRVAEPWFDPALLLLARDADGRLAGFHWLKVEGGQAEVYVLGVDPDRAARGLGSALLAAGLDLLAARGLDEVDLYVEADNAPALALYRRAAFRDAAVDVQYRRA
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: EFTS_SALTI
Sequence: MAEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIDGNVAFILEVNCQTDFVAKDAGFQAFADKVLDAAVAGKITDVEVLKAQFEEERVALVAKIGENINIRRVASLEGDVLGSYQHGARIGVLVAAKGADEELVKQLAMHVAASKPEFVKPEDVSADVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKSVGQLLKEHNADVTGFIRFEVGEGIEKVETDFAAEVAAMSKQS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_STRP1
Sequence: MRKDIHPDYRPVVFLDTTTGYQFLSGSTKASKETVEFEGETYPLIRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLKDANAAK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: RRP4_ARCFU
Sequence: MRKIVLPGDLLSTNPRAAGYGTYVEGGKVYAKIIGLFDQTETHVRVIPLKGRYTPSVGDVVIGIIREVAANGWAVDIYSPYQAFLPVSENPEMKPNKKPNEVLDIGDAIIAKVLNIDPKMKVTLTMKDRICRPIRFGRIVAINPARVPRVIGKKGSMIKLLKSELDVQIVVGQNGLIWVNGDRRKVSIAEEAIYLIEQEAHTEGLTDRVAEFIKRRKADVGIQ
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Confers strong poly(A) specificity to the exosome (Probable).
What are the official names of this protein?
Exosome complex component Rrp4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCED1_SOLLC
Sequence: MATTTSHATNTWIKTKLSMPSSKEFGFASNSISLLKNQHNRQSLNINSSLQAPPILHFPKQSSNYQTPKNNTISHPKQENNNSSSSSTSKWNLVQKAAAMALDAVESALTKHELEHPLPKTADPRVQISGNFAPVPENPVCQSLPVTGKIPKCVQGVYVRNGANPLFEPTAGHHFFDGDGMVHAVQFKNGSASYACRFTETERLVQEKALGRPVFPKAIGELHGHSGIARLMLFYARGLFGLVDHSKGTGVANAGLVYFNNRLLAMSEDDLPYHVKVTPTGDLKTEGRFDFDGQLKSTMIAHPKLDPVSGELFALSYDVIQKPYLKYFRFSKNGEKSNDVEIPVEDPTMMHDFAITENFVVIPDQQVVFKMSEMIRGGSPVVYDKNKVSRFGILDKYAKDGSDLKWVEVPDCFCFHLWNAWEEAETDEIVVIGSCMTPPDSIFNECDEGLKSVLSEIRLNLKTGKSTRKSIIENPDEQVNLEAGMVNRNKLGRKTEYAYLAIAEPWPKVSGFAKVNLFTGEVEKFIYGDNKYGGEPLFLPRDPNSKEEDDGYILAFVHDEKEWKSELQIVNAMSLKLEATVKLPSRVPYGFHGTFINANDLANQA
What is the function of this protein?
Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity.  Catalyzes the first step of abscisic-acid (ABA) biosynthesis from carotenoids.  Required for ABA accumulation upon drought (Ref. 2).  Required for ABA-mediated regulation of anther/pollen development, including metabolism, cell wall modification and transcription level (PubMed:29632966).  Positive regulator of fruit ripening involved in the biosynthesis of abscisic acid (ABA); initiates ABA biosynthesis at the onset of fruit ripening (PubMed:19246595, PubMed:22108525, PubMed:25039074).  Modulates the degree of pigmentation and carotenoid composition as well as pectin catabolism during ripening and may regulate the ethylene production and action in climacteric tomato fruit (PubMed:22345638, PubMed:22108525).
What are the official names of this protein?
9-cis-epoxycarotenoid dioxygenase NCED1, chloroplastic, LeNCED1, SlNCED1, Nine-cis-epoxycarotenoid dioxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Note=Partially bound to the thylakoid.
Protein: DPH2_RAT
Sequence: MESTFSSPAEAALQREAGVPGQFTPPEDLDRVYELERVTRFICDLGCQRVALQFPDQLLGDAGAVAARLEEVTGSKMFILGDTAYGSCCVDVLGAEQAGAQALVHFGPACLSPPASLLPITFVLGRRPVALELCAKAFEAQNPDPTALVVLLSEPACAHALEPLATLLRPKYQDLLISSPALPLPVGSLSSQPESLERFGRRFPLNPGRSLEEYGAFYVGASQASSDPNLDPDLSRLLLGWTPGRPFFSCCPDTGQTQDQGAKAGRLRARRLYLVERARDARVVGLLVGTLGVAQHLEALAHLRKLTEAAGKRSYVLALGKPTPAKLANFPEMDVFVLLACPLGALTLQPSGGFFRPILTPCELEAACNPAWPPPGLAPHLTHYAELLPGSPFHVPLPPPESELWDTPDVSLISGELRPPPPWKSSDDTKCSALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVKEAVQGRRGIAIAYEDEGSS
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity).  Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, Diphthamide biosynthesis protein 2, Diphtheria toxin resistance protein 2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH2 subfamily.
Protein: DNAK_PARPJ
Sequence: MGKIIGIDLGTTNSCVAIMEGNSVKVIENSEGARTTPSIIAYMEDGEILVGAPAKRQSVTNPKNTLYAVKRLIGRRFEEKEVQKDIALMPYKIMKADNGDAWIEVRDQKLAPPQISAETLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKAEKGDRKIAVYDLGGGTFDVSIIEIADVDGEMQFEVLSTNGDTFLGGEDFDQRIIDYIIAEFKKEQGVDLSKDVLALQRLKESAEKAKIELSSSQQTEINLPYITADASGPKHLDLKITRAKLEALVEELIERTIEPCRVAIKDAGVKVGEIDDVILVGGMTRMPKVQEKVKEFFGKDPRRDVNPDEAVAVGAAIQGQVLSGDRKDVLLLDVTPLSLGIETLGGVMTKMINKNTTIPTKHAQVYSTADDNQGAVTIKVFQGEREMAAGNKLLGEFNLEGIPPAPRGTPQIEVSFDIDANGILHVGAKDKATGKENRITIKANSGLSEAEIEKMVKDAEANAEEDHKLRELADARNQGDALVHSTKKALTEYGDKLEAAEKEKIEAALKDLEETLKSGSADKAAIEAKIEVVATASQKMGEKMYADMQAAQGAEAAAAGAAGAGATAGGASQQQDDVVDAEFKEVKKD
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CDMJ_TALVE
Sequence: MLSEDLATSFLPPSYMWSLTLFALCLSAILMFPFLTGRRLSITHRKQGWRISLVNTRGDFQNEAEQLIRMGFSKSPSAFRMSTDGGPRLILSQKHLDAMSDDDHFNVAEAVKRDYLLDLFGFETAFHGTLHSEIVAPAVTAMTKKLVPLVPLMSKEAALGLEKEWTDNSEYHDVPLQPTLGGVVARLASLAFVGPDLCRNPTWLEITVSYTINRVIAVYVLRIFPSFLQPFVHWVLPPCRKLRAQIQQARELILPALKHERQLQSAGNAKRDPNRPFSSLAWNDEYAAGRLYDPTVAQLRMIFVSIHTTIDMAVKVLVRLCEHPELIQPLREEIVTVCGENGLTHSSLERLLLMDSLMKETQRLEPASLATIARYTHRKTTLSDGTIVPKGTQVVLPNMFMWNNESIYPDSNTFDAYRFLRMRDDPETAKLASFTRSSHIHTAFGHGKHTCPGRFFASDTIKIILCHILLKYDLQLCDGEAPAKKRYGFAMYRDPDARIRVRRRGVEGVSEGILAGF
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of chrodrimanin B, a meroterpenoid that acts as a potent blocker of insect GABA-gated chloride channels (PubMed:30417647).  The first step of the pathway is the biosynthesis of 6-hydroxymellein by the polyketide synthase cdmE (PubMed:30417647).  The prenyltransferase cdmH acts as a 6-hydroxymellein 5-farnesyltransferase and produces the hydrophobic metabolite verruculide C (PubMed:30417647).  The FAD-dependent monooxygenase cdmI further converts verruculide C into verruculide B (PubMed:30417647).  The terpene cyclase cdmG then produced the pentacyclic molecule 3-hydroxypentacecilide A, the backbone structure of chrodrimanin B, via folding the farnesyl moiety of the substrate into the chair-boat conformation (PubMed:30417647).  The short-chain dehydrogenase/reductase cdmF functions as the 3-OH dehydrogenase that oxidizes the C-3 hydroxyl group of 3-hydroxypentacecilide A and produces chrodrimanin C, the dehydrogenated product of 3-hydroxypentacecilide A (PubMed:30417647).  The cytochrome P450 monooxygenase cdmJ then accepts both 3-hydroxypentacecilide A and chrodrimanin C and functions as a C-7-beta-hydroxylase to produce respectively chrodrimanin H and chrodrimanin F (PubMed:30417647).  The dioxygenase cdmA accepts chrodrimanin H to afford chrodrimanin E, which is further transformed to chrodrimanin A by the dioxygenase cdmD (PubMed:30417647).  CdmA can also accept chrodrimanin C as substrate to convert it into verruculide A, which is further converted into chrodrimanin T by cdmD (PubMed:30417647).  The last step of the biosynthesis is proposed to be performed by the acetyltransferase cdmC which acetylates chrodrimanin A to yield chrodrimanin B (Probable).  The pathway may also lead to the production of additional shunt products, including chrodrimanins T and U (PubMed:30417647).
What are the official names of this protein?
Cytochrome P450 monooxygenase cdmJ, chrodrimanin B biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: KDSA_SYNP6
Sequence: MGQSTLIRAKVGDRFSIGDGCPLTLFGGPCVIEGEDFSLKMAESIAKVCDRLGVQFVFKSSFDKANRTSIGSFRGYGLEEGLRILERVKTELGLPVLTDIHESQQAATVAEVVDILQIPAFLCRQTDLLLAAAATGRTVNVKKAQFLAPWDMKNVVNKLRQGGAENLLLTERGSCFGYNALVVDFRSLPLMRELGCPVVFDATHSVQIPGGAGDRSSGQREFVPVLARAAAAVGIDALFMEIHENPDQALSDGPNMIRLADLEATLRHILRVREAVAEPIGASA
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBN2_MICAN
Sequence: METATILGISIAAALVGITVLALYTAFGPPAAELSDPFEDHED
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN 2.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PNP_STRPN
Sequence: MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAVMSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQIIINPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQEEIVAAVGKEKAEVELLHVDAELQAEIIAAYNSDLQKAVQVEEKLAREAATQVVKDQVTAVYEEKYADHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAVVDFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGETGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITALQMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRPELAPTAPKIDTIKIDVDKIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKVDEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNRVEDLVEIGDEVDVKVIKIDEKGRIDASMKALLPRPPKPEHDEKGEKSERPHRPRHQKDYKPKKEFTETSKDSE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: D2HDH_ORYSJ
Sequence: MARRAAAGLLRRHLGPLAAGETLQARGMYPKQYGAANHAFSRFYSIQGQQRSLYGFRTNVETDDTQQSARMNFEVQKRSFSSAAAHVQRNPAYSVLNSDDVSYFKSILGDSGVVQDEDRVSVANMDWMGKYKGSSQLLLLPKSTAEVSKILSYCNSRRLAVVPQGGNTGLVGGSVPVYDEVIISLGGMDKIITFDNVNGILTCEAGCVLENLSSYVENKGFIMPLDLGAKGSCHIGGNISTNAGGLRFIRYGSLHGSVLGLEVVLADGTVLDMLTTLRKDNTGYDLKHLFIGSEGSLGIVTKIAILTPAKLPSTNVAFLSCNDYISCQKLLLAARRSLGEILSAFEFMDRHCINLAMKYLEGVHNPLPVSPFNFYVLIETTGSDESYDKAKLEAFLLRSMEDGLVADGVIAQDISQASNFWRIREGISEASVKVGAVYKYDLSIPVEKLYDIVEEMRSRVGDMGQVLGYGHLGDGNLHLNILSTKYSDKMLAQIEPFVYEWTSKQRGSISAEHGLGLMKAEKIHYSKSSEAVQLMASIKKLLDPNSILNPYKVLPQSVL
What is the function of this protein?
Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.
What are the official names of this protein?
Probable D-2-hydroxyglutarate dehydrogenase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DOIS_STRFR
Sequence: MQTTRIAMEDASFPYRLGTDCAEDVVARLAALEASSYLVVADTTVAELYGAALTAHIDKEAGPSHLLTHEVGEVHKTLATVSALAEQALGRGADRRSVVVALGGGVTGNIAGLMASLLFRGIRLVHVPTTVVAMLDSVLSLKQAVNTTFGKNLAGTFYQPVEVLADTAALRTLPPREIRSGMGEVVKNALAIRPAMLDRLAGALRPDTRYDDETMRWIIAESLAAKADVTSGDKHERRSGLVLEYGHTAGHAIEHASRGAVAHGAGVAVGMTLAAEVSRRLGHADAGLVALHRELVAAAGVEPAVPDHVDTALVKNWLAYDNKRGYLDSPPGHTPMVLLSAPGEVLHTGTMPLVPVPLALLEEVVDESAARGGAGGGAAEPAAARTGPVPDGPEAAVPATPGPVPAGPAAAAPLPSGPAPTAPAAAGPVP
What is the function of this protein?
Catalyzes the intramolecular carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose (DOI).
What are the official names of this protein?
2-deoxy-scyllo-inosose synthase, DOI synthase, DOIS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. DOI synthase family.