PharMolix/UniProtQA huggingface dataset:
Protein: CLPX_MYXXA
Sequence: MAGKNVEKRDNQTLCCSFCGKSQKEVKKLIAGPTVYICDECIGLCNDIIAEEIDREETKDTKLRIPRPSEIKAVLDEYVIGQERAKKTLSVAVHNHYKRIESKVAMEDVELQKSNILLLGPTGSGKTLLAQTLARILNVPFTIADATCLTEAGYVGEDVENIIVNLLQAADHDIERAQRGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKLIEGTVANVPPKGGRKHPQQEFLQVDTTNILFICGGAFGGLDQVIERRMGGRSLGFGADVQSKKQRSLTELLKHVEPEDLLKFGMIPEFIGRLPIITALEELDEAALINILNQPKNALTKQYRKLFELDGVTLKFTDGALKAIANEAIRRKAGARGLRSILESAMLDVMYEIPSRKTAREVLISEEVILKKSEPVVLHAQPEKEAAEPKKESA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: NU2M_ANOQU
Sequence: MKKISNNIFFITLIFGTLVTISSNSWLGAWMGLEINLLSFIPLMNDNKKNLLTSESSLKYFLTQAFASSILLFAIIMLMFFYNNNFLLMNNYNEILILSTLLLKSGAAPFHFWFPEVMEGLSWINGLFLMTWQKIAPLMLISYNFIYNFFMISIILSMLIGSLGGLNQTSIRKLMAFSSINHLGWMLLAMMNNEMLWMTYFLIYSLLSISIVLMFNNFKLFYFNQIFNISLMNPIIKLLIFLNLLSLGGLPPFLGFLPKWLVIQNLTNMGQLFILTISVCLTLITLFFYLRLSYSIFMLNYQKNSWMLKNNYNNKMSSINLLLNFISISGLIMIFMIYMIM
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HELE_ASPFU
Sequence: MAARQLRRLSLPTHLPLPIRPHVRHLGTAQTNCHRFDHETDILIVGSGAAGLTAALRSHFHGLSSLVIEKDAQIGGTSAYSGGGLWIPNNPLAVEAGIIDTPEQAMTYLISVIDADTAEDTDVRRASSPPRKRAFLTHGPHMVSFLRDRGFAFRLSPGCPDYYPQAHGALPTGGRSIEPDVFDARLLGLGEKWTEAIRQRPGRSLPLFTYEASSVTRMGASWRDVGTVLRVLLRGIYLSRVRGQIPVTMGKSLVAQLLWLHMQLDQGPVLTDTALRQLIATPEGVILGARVATPDGERSIRARCGVLLCAGGFAHNQGLRERYGPVPANAEWTSAARGDNGDAIVAGVRVGAATALMDEAWWGPTLRDPVRGMYYFALQERARPFGVIVDSSGKRFMNEAEPYTDAGHHQYAQKAVPAWFVFDWNHRKRYAVGSLMPRQQPPAQALDAGYIHRADTIAELARQIGVNEKGLEGTLARFNEMADCGVDSDFARGESAFDNYFGDPTVRPNPNLGAVRTPPFYAIPLVPGDLGTKGGLLTDEHARVIREDGTPVQGLYAAGNTTASVMGRTYPGAGATLGPAMTFAFIAIDHIASEHV
What is the function of this protein?
3-ketosteroid 1-dehydrogenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol)(PubMed:19415934, PubMed:19216560, PubMed:29158519).  The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid (PubMed:19216560).  Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C-16, acyltransferase helD2-dependent acetylation of 16-OH, oxidation of C-21 by cytochrome P450 monooxygenase helB4, and short chain dehydrogenase helC-dependent oxidative decarboxylation yield the fusidane skeleton (PubMed:29158519).  This intermediate is further modified in three additional steps mediated by the cytochrome P450 monooxygenase helB3, the acyltransferase helD1, and the 3-ketosteroid 1-dehydrogenase helE to give helvolic acid (PubMed:19415934, PubMed:19216560, PubMed:29158519).  Compared with the late stages in the biosynthesis of helvolic acid, enzymes involved in the early stage modifications act in a relatively strict order (PubMed:29158519).  The hydroxylation of C-16 by helB1 and subsequent acetylation by helD2 should occur before the helB3-mediated oxidation of C-21 (PubMed:29158519).  C-4 demethylation in fusidane-type antibiotics proceeds in an unusual manner though it is also achieved by oxidative decarboxylation (PubMed:19415934, PubMed:29158519).  The methyl group at C-4 beta position is oxidized by helB1 and subsequently removed by the short chain dehydrogenase helC (PubMed:19415934, PubMed:29158519).
What are the official names of this protein?
3-ketosteroid 1-dehydrogenase helE, Helvolic acid biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily.
Protein: NADA_SHIF8
Sequence: MSVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHPASTLLVAGVRFMGETAKILSPEKTILMPTLQVECSLDLGCPVEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIDHLDSLGEKIIWAPDKHLGRYVQKQTGGDILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVDMADAVGSTSQLIAAAKALPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWMAMNGLQAIAEALEQEGSNHEVHVDERLRERALVPLNRMLDFAATLRG
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDA_SHIBS
Sequence: MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: MNME_KORVE
Sequence: MNLDDTIVAIATPPGRGGIGVVRLAGPEARTVALLMLRLANGKAELEAQRAHFAELVDPESGERLDEVVVAYFAKPHSYTTDDIVEISCHGSPVLLARVVELALAKGVRMADPGEFTMRAFLNGRIDLTQAEAVRDLIESQTLYQARVAAQQLGGSVSRRLQPTKQKLVNLIAVLEAGIDFADDDVSVLPAKEAIARIAEVHEPLAKLKEGFAFGKVVHEGLTLAIVGRPNVGKSSLFNRLVERDRAIVTAIPGTTRDLVTETVSLGGIPVHLVDTAGIRESHDEAESIGIQKSREAMADADLVLVVVDAHAETGHELDHQLISAAAERSAILVENKIDLGRHSVANGKSIPVVRTSAVSGEGIAELREQILRMVSGESGREESGFLTNIRQHQLVTDSLAALEAATNALEVRVPHEMVLMDLYNALRPLDDITGATTADDILNLIFSTFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_ECOLC
Sequence: MIGLVGKKVGMTRIFTEDGVSIPVTVIEVEANRVTQVKDLANDGYRAIQVTTGAKKANRVTKPEAGHFAKAGVEAGRGLWEFRLAEGEEFTVGQSISVELFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGQMGNERVTVQSLDVVRVDAERNLLLVKGAVPGATGSDLIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: CASK_PIG
Sequence: MMKSSFLIVPILALTLPFLGAEEQNQEKLTRCESDKRLFNEEKVKYIPIYYMLNRFPSYGFFYQHRSAVSPNRQFIPYPYYARPVVAGPHAQKPQWQDQPNVYPPTVARRPRPHASFIAIPPKKNQDKTAIPAINSIATVEPTIVPATEPIVNAEPIVNAVVTPEASSEFLITSAPETTTVQVTSPVV
What is the function of this protein?
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
What are the official names of this protein?
Kappa-casein.
What is the protein family that this protein belongs to?
Belongs to the kappa-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: PLSX_SODGM
Sequence: MRRLTLALDAMGGDFGPAVTVPAALQALVSYPQLELLLVGNPAAIHSLLVKTDSVLLERLTVIPAESVITSDAKPSQAIRASRGTSMRVALELIRDGRAQACVSAGNTGALMGLAKLVLKPLDGIERPALMVVLPHKKQGKTVVLDLGANVACDGAMLAQFAVMGSVMAEHIVGVTNPRVALLNIGEEETKGLDPIQHAAVLLRDVQSINYIGYLEANELLTGKTDVLVCDGFVGNVTLKTMEGVIRVFLSLLKSSGESGRQGWLMQWVKRWMKRRLMRQFGQLNPDQYNGACLIGLRGTVIKSHGAANQRAFTAAIEQAMQAVERQIPERIAARLDAVLPKSD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: YPFN_ECO27
Sequence: MDWLAKYWWILVIVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDDDDDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CADM2_RAT
Sequence: MIWKRSAVLRFYSVCGLLLLGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQALTLTCESKGKPLPEPVLWTKDGAELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTAPVTTTVAITTSPSTSASSSSRRDPNSLAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI
What is the function of this protein?
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation.  Important for synapse organization, providing regulated trans-synaptic adhesion.  Preferentially binds to oligodendrocytes (By similarity).
What are the official names of this protein?
Cell adhesion molecule 2, Immunoglobulin superfamily member 4D, IgSF4D, Nectin-like protein 3, NECL-3, Synaptic cell adhesion molecule 2, SynCAM 2.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.
Protein: P14_ASFB7
Sequence: MADFNSPIQYLKEDSRDRTSIGSLEYDENSDTIIPSFAAGLEDFEPIPSPTTSTSLYSQLTHNMEKIAEEEDINFLHDTREFTSLVPDKADNKPEDDEESGAKPKKKKHLFPKLSSHKSK
What is the function of this protein?
Structural protein required for transport of intracellular particles from the assembly sites to the plasma membrane (PubMed:11435554).  Binds to both ssDNA and dsDNA (PubMed:9123862).  Suppressed the activation of the cGAS/STING pathway by interfering with the recruitment of IRF3 to TBK1, which in turn suppresses IRF3 phosphorylation, decreasing interferon production (PubMed:34190598).
What are the official names of this protein?
Protein p14.5, pE120R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus structural protein p14.5 family.
What are the subcellular locations of this protein?
Virion. Note=Localizes at the surface of the intracellular virion.
Protein: ABCG3_DICDI
Sequence: MEDKNNIELQEKAPDNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDINNNDDDNNKIIYQNPTPASSSHIDSIEIDINYDLSNHIKQRVTQNKTGMFVSANNISYYIPKSIKKGESEELSKLYLLNNISFTMKPGRMILLMGIPGAGKSLLLKVLGNRLGKGKIEGELKFNNHEVDETTHQRDTIFVSQDDRHIALLTVRETLEFSAKCNMGENVSQEEQSERVDLVLDQLGLSHTSNTIIGNQFFRGISGGQKRRVTIANEFTKRSPNLILMDEPSTGLDSATSYNVISKVKTIAKEAKASVMVSLLQPSVELTNLFDDILILGEGGNLIYFGELNNLLPYFSSIGLAPLPNQPLAEFMQEVSVEPSKYMITDKIELSSKDGGDDESKSLLLGGADSGNVEKMDLVKLFKESELNQKTIQSMQQLIPSDIKVSDHLIKKLETGDNGKSSVRYELKHLLARHIKVMKIMKMQYAVRFFQAIFMGCVIGSLFVKMGFTQADARNRFGLVYFAMVLHIWTTIGSVEEFFTLRGIFDDQKDSKYYRNFPYFLSLVITKIPISLIEAILFSSCCYWIAGFQARVDNFIVFILGMALTNLIAQGIFQVTSAFTSAQLLASLICPAIVVLFMIMSGYMISRLQIPGWWIWLNALSPLRYVIDMVSSNELYGLEFHCSPMEKIPPSNYPLLNVSYADGGYQGNQICQYSTGSDFLNQFGFSDNSYMRWVDIVIILGFVCTFFFIFFLGVKYIRFENKKPPRQIKLKKKKEKKDKKDKEVKHKWNGCYMTFQNLNYVVPSVKDNKETGKKEKVTLELLKDVNGFIVPGMCALMGPSGAGKSTLMDVLAKRKNVGTITGDIRINGQLVKDMNITRFTGYVEQQDILSANLTVREAIEFSANCRLPSSYLQKDRVKLIDEILSVLSLTKMQNTTIGPNPTLGISLANRKKVSIGIELASDPHLIFLDEPTSGLDSSAALKVMNCVKKIAESGRTVVCTIHQPSQEIFEKFDQLLLLDKGKVIYFGDTGDNSSTVIQHFTSAGYQYEHGRNPADFILEIAEHPPSTGQSASDYFKSSIHYSNSIQRLESKTIVPEGVDVPKYKGKYSAPATAQLHSLVKRGWLNHVRRPQTILLRFLRSFIPAIVIGTLFLRLDNDQTGARNRIALVFLGFLFGGMASIGKVPTIVEDRSVYYRESSAGTYPAHLYILASVITDLPMMVLTAFSYWIPMFFLTGLTLGDHGWKFFFSLSVYLLVIMCYDSLATLFALTLPTIPIAILVSGVGLNFLGLFGGFFIPVNNIPRGWIWMHYLVFSKYGLETLSITELKGEPFFCEEDQYSIIPIAGTNFTKKYCAIQSGDTMLLQYGMNDAYDRQFYNLIILGGYFCAYTFLGYLALRFINHMKR
What are the official names of this protein?
ABC transporter G family member 3, ABC transporter ABCG.3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y2223_CERSK
Sequence: MTDLYIDADACPVKAEAERVAVRHGVRMFLVSNGGIRPPAHPLVESIFVPEGPDVADMWIADRARTGDVVVTSDIPLAAKVVAAGALVVKPNGETLTQANIGNALATRDLMADLRSADPFRQGSGRPFSKADRSRFLDALERAMRKAQEAGRSASGGSEAGS
What are the official names of this protein?
UPF0178 protein RSKD131_2223.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: ESA1_USTMA
Sequence: MAPRTQKSTSGTPGGSGTPGPDEGPQISPGGTYGLEDVVVGCKAFVQKPDVVTGEMEERKAEILSIREKPKPRLTKKQQAELADKPAPTLEETLEYYVHYCEFNKRLDEWVSGTRLITSRELEWPKKEVTSDKTKRKVIRAGSGATTPSTPLTPTGKGYRGAGASNLLKKAAAQAAKNVQGESGLETPQKRKADSGDTSTAQSIRADSIDADADGEDDENGAVVAMEMLGGNDQQEKDDVATESNGGLTASLNANQGQETFSKKQEIEKLRTSGSMTQSVSEVARVKNLNKIQMGKSEVETWYFSPYPLEYAHIDTLYICEMCLSYFPSPFTLKRHRSKCTLLHPPGNEIYRHEDISFFEIDGRLQRTWCRNLCLLSKCFLDHKTLYYDVDPFLYYCMVKRDDLGCHLLGYFSKEKDSAENYNVACILTLPQHQRAGYGKLLIEFSYELTKIEGKLGSPEKPLSDLGLLSYRAYWAEIIVELLLKTEDEISIEEIAQKTAFTHADILHTCMALNMLKQYQGKHMIVLSDLIISKYTAKRPRKRINPQKLHWTAKNWHRSQLNFGW
What is the function of this protein?
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A. Z (By similarity).  Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity).  The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation.  The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity).  Recruitment to promoters depends on H3K4me.  Also acetylates non-histone proteins (By similarity).  In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
What are the official names of this protein?
Histone acetyltransferase ESA1, Protein 2-hydroxyisobutyryltransferase ESA1, Protein acetyltransferase ESA1, Protein crotonyltransferase ESA1.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs).
Protein: ARGC_METPE
Sequence: MDIAIIGATGYAGGELIRLLGMHSAAEVVCATSRRVEGTRVSAVHPQLNGFTDLSFTNPSVDEIEADVAFLAVPHTAGMQYVRALLERGIRVVDLSADYRLPQEIFEKVYGVTHTDYFAAPYGLPELHREEIRGKHFIANPGCFPTGATLAAAPLAAFADTIIYDSKSGVSGAGDNPSATTHFPNVADAITPYKMTTHRHLAEMKMELERLHAKAACYFTPHLLPVNRGILTTAHILLRDPLNQDQVERIYKDYYKDESFVRYQKPSIAAVRGSNFCDLIVESEGKRVVAVSAIDNLVKGASGQAIQNMNLMCGFKENDGLASAGLFP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEGLY_PYRAB
Sequence: MRVLILSADQFEDVELIYPYHRLKEEGHEVLVASFKRGVITGKHGYTVNVDLAFEEVNPDEFDALVLPGGRAPERVRLNEKAVEIAKKMFSEGKPVASICHGPQILISAGVLRGRRGTSYPGIKDDMINAGVDWVDAEVVVDGNWVSSRVPGDLYAWMREFVKLLK
What is the function of this protein?
Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals.  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage.  Also displays proteolytic activity.
What are the official names of this protein?
Deglycase PYRAB04690, Intracellular protease PYRAB04690.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_PORG3
Sequence: MAANNQGEIRYLTPLSVDTKKKKYCRFKKSGIRYIDYKDPEFLKKFLNEQGKILPRRITGTSLKFQRRVAQAVKRARHLALLPYVTDMMK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: Y3716_MYCTU
Sequence: MQPGGDMSALLAQAQQMQQKLLEAQQQLANSEVHGQAGGGLVKVVVKGSGEVIGVTIDPKVVDPDDIETLQDLIVGAMRDASQQVTKMAQERLGALAGAMRPPAPPAAPPGAPGMPGMPGMPGAPGAPPVPGI
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Rv3716c.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: METXA_PELUB
Sequence: MNINVNIKNIIIDKPLKLDCGQTINNYSLAYETYGSLNENKDNAILIFHALTGDQFVSGINPITKKEGWWSYAVGSGKAIDTDKYFVICANVIGGCMGSYGPSEINPDTNKKYGTTFPVITINDMVNAQFNLLNFFNIEKLFAVMGGSMGGMQTLQFVNNFPDKAKVAIPIACTASHSAQNIAFNELGRQSIMADANWENGDYSNQNKNPNKGLSVARMAAHITYLSKNGLQEKFGRKLQERDDLKFGFDADFQIESYLRYQGSVFVDRFDANSYLYITRAMDYFDLVKEHHGNLSKAFEKTKTKFLIISFTSDWLYPTSENKEIVIALNAIGAEVGFVEIESDKGHDSFLLKVPKFLNTLGDYIKTAYSKN
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METN_STRT2
Sequence: MSNVIIDLKNIDITFTQKRRTIQAVKDVSIQIEKGDIYGIVGYSGAGKSTLVRAINLLQVPTAGKITIGEDVTFEDGKVQLTTKELRQKRQTIGMIFQHFNLMAQKTAYENVAFALRHSKLSNEEKDKKIRGLLELVDLADRAENYPAQLSGGQKQRVAIARALANDPEILISDESTSALDPKTTKQILSLLQDLNKKLGLTVVMITHEMQIVKDICNRVAVMQNGQLLEEGSVLDIFSNPQEDLTQEFIETAAGIEDALAKINAQPLVKNLPASALLVQLKYVGSSTDRPLLTEIFKDFGVSGNILYGNVEILGDTPVGELVVVLDGDSDKVIAALKAIENAGVSLRVLKKGAQ
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ACP1_SPIOL
Sequence: MASLSATTTVRVQPSSSSLHKLSQGNGRCSSIVCLDWGKSSFPTLRTSRRRSFISAAKKETIDKVCDIVKEKLALGADVVVTADSEFSKLGADSLDTVEIVMNLEEEFGINVDEDKAQDISTIQQAADVIESLLEKKA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein 1, chloroplastic, ACP I, Acyl carrier protein I.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYP_CLOBA
Sequence: MKMSNMLISTLREVPAEAEIDSHKLMLRSGMIRKMASGIYNYMPLGLKALKKVEDIIREEMNEAGAQEFLASAMIPAELWQSSGRWDAYGAEMFRVKDRNERDFCLGPTHEEVFTDIAKNEIKSYKQLPVNLYQIQTKYRDERRPRFGVMRSREFVMKDAYSFDKDQQGLDLSYNKMYEAYVKIFNRCGLDAKCVEADSGAIGGSNSAEFMVKSEVGEDDIVFCTECDYAANIEKATARLEEEEKEELLEVEKVSTPDSRGIDEVSEVLNISSKKTVKTLLYNVDGKIVAVFVRGDREVNEVKVANASNASGDIEMVSHEEYMNATGCGIGFAGPIGIKADLILVDKEVKNMCNFVTGANETGYHIKNVNYGRDFEGIIGDYRNVVEGEACSICGGKLTISRGTEVGHIFKLGTKYSEAMDAKFIAENGKEAPFIMGCYGIGVTRTMASIIEQHNDESGIVWPLAVAPYHVSVIAVNVKDEEQVKIATKLYEDLKSIGVEALLDDRNERAGVKFKDSEIMGIPMRITVGKKIVDGEVEFKLRTGDMEVVKIEDVCQIVKGEFDKNNLKLR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_ECOL5
Sequence: MNLNSIPAFDDNYIWVLNDEAGRCLIVDPGDAEPVLNAISANNWQPEAIFLTHHHHDHVGGVKELVEKFPQIVVYGPQETQDKGTTQVVKDGETAFVLGHEFSVIATPGHTLGHICYFSKPYLFCGDTLFSGGCGRLFEGTPSQMYQSLKKLSALPDDTLVCCAHEYTLSNMKFALSILPHDLSINDYYRKVKELRAKNQITLPVILKNERQINVFLRTEDIDLINVINEETLLQQPEERFAWLRSKKDRF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.