PharMolix/UniProtQA huggingface dataset:
Protein: KC1G3_PONAB
Sequence: MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARHMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQSADHRAAWDSQQANPHHLRAHLAADRHGGSVQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRKTIQRHK
What is the function of this protein?
Serine/threonine-protein kinase.  Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  It can phosphorylate a large number of proteins.  Participates in Wnt signaling.  Regulates fast synaptic transmission mediated by glutamate (By similarity).
What are the official names of this protein?
Casein kinase I isoform gamma-3, CKI-gamma 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCP2_BACSU
Sequence: MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLGGGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIMIDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYAGRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV
What are the official names of this protein?
Stress response protein SCP2.
What is the protein family that this protein belongs to?
Belongs to the CAPAB/TerDEXZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RADA_RICTY
Sequence: MTRDKKHYICSNCANISHKWSGQCFDCGVWGSIVEEIISTNKSIITGSKQTFDKLSCDVSEPLRISTPISELNRVLGGGLVLGSAILIGGEPGIGKSTLLLQLTASNFESKMRCLYITGEESLDQIKLRAIRLNITNYNTAILAATNLEDIIASIDDNNNNIDLVVIDSIQTITTKELSSPPGTVSQIRTCANELVNYSKQNNIIILLSCHVTKDGQIAGPKILEHLVDTVLYFEGDHNNHFRILRSYKNRFGSIGEIGVFEMSSSGILEVTNHSELFLMKREHNVVGTSIFAGVEGSRPLLMEVQALIVPSNMLTPKRSAVGWDANRLSMILAVLSSRIGLNLANYEIYLSIAGGLKITDPASDLAVAASLISAATSIPLPEHSVFFGEISLSGEIRKTAKAETRIKEAVKLGFNKVICSKLENLTYDFICSCTHLQDLKEIIK
What is the function of this protein?
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks.  Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster.  Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB.  Does not have RecA's homology-searching function.
What are the official names of this protein?
DNA repair protein RadA, Branch migration protein RadA.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RadA subfamily.
Protein: DCI1_ARATH
Sequence: MTMESYKTLEIIRKNTDSSVFHLIINRPSHLNALSLDFFIEFPKALSSLDQNPDVSVIILSGAGKHFCSGIDLNSLSSISTQSSSGNDRGRSSEQLRRKIKSMQAAITAIEQCRKPVIAAIHGACIGGGVDLITACDIRYCSEDAFFSIKEVDLAIVADLGTLQRLPSIVGYANAMELALTARRFSGSEAKDLGLVSKVFGSKSELDNGVTTIAEGIGGKSPLAVTGTKAVLLRSREVSVEQGLDYVATWNSAMLISDDLNEAVSAQMMKRKPRFAKL
What is the function of this protein?
Converts 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs.  Involved in degradation of unsaturated fatty acids.
What are the official names of this protein?
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, peroxisomal, AtDCI1.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: BMAL1_HUMAN
Sequence: MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
What is the function of this protein?
(Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression.
What are the official names of this protein?
Basic helix-loop-helix ARNT-like protein 1, Aryl hydrocarbon receptor nuclear translocator-like protein 1, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, bHLHe5, Member of PAS protein 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, PML body. Note=Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2.
Protein: CHI2_CAPCH
Sequence: GPIQISYNYNYGPCGRYCGILGVSPGDNLDCGNQR
What is the function of this protein?
Defense against chitin-containing fungal pathogens.
What are the official names of this protein?
Endochitinase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: LOLB_VIBVY
Sequence: MFRRTYFWLMLLPLFMVGCTGLPDHPTSVEWQSHQAKLSQIQSFQAVGKLGYISPDQRQNLNFYWKHSPEQSNLRFTTFLGQTALNLTMTPQGARVETYDDQILTAANATALVQQLTGLVIPVEQLSDWIIGLPNGADDFQLNEQNTLSSLEKDLNFQRWHIAYTQYRDVEFHQQVVPLPAKLSLTQQDIKLNIVVSKWTLK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RS8_MALP2
Sequence: MYMDPISDLLLRIKTGTKTKRNSVVVKTSKLVTNILEILKNEGYIEGFKTESIGKNKNQTVVNLKYRNNVSSITGLKQISKPGLRIYSEAQKLPKVLNGLGIAIISTSMGLMTDKNAKKNNVGGEVIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: TRUB_HELHP
Sequence: MANALLVAAYKPPFLSSNACLSRLKKHFGMSKAGYLGTLDPFAKGVLVVGFGSYTRLFPHLQKVPKAYRATLWLGAKSASLDIEHIESIEIIPEYNQSDIEKILFSLKGTFDYTPPAFSAKHINGQRAYKLAREGKVFTLQQIQMSIYNITLLSYHHPFVHFEVSVSEGAYVRSIGEIIAKKLGVNGVLSSLERISEGQMSVSATEQIRILNPLEYLPYPQLENMHRFSKQMYDGKKITLKNAQKGKYIVCFEDFFSIIEIFSNGGIQYILNRIEYVDTFKKTR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: HEMA_I40A0
Sequence: MKAKLLILLCALSATDADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCRLKGIAPLQLGKCNIAGWILGNPECESLLSKRSWSYIAETPNSENGTCYPGDFADYEELREQLSSVSSFERFEIFPKERSWPNHNINIGVTAACSHAGKSSFYKNLLWLTEKDGSYPNLNKSYVNKKEKEVLVLWGVHHPSNIENQKTLYRKENAYVSVVSSNYNRRFTPEIAERPKVRGQAGRMNYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGLGSGIITSNASMDECDTKCQTPQGAINSSLPFQNIHPFTIGECPKYVRSTKLRMVTGLRNIPSIQSRGLFGAIAGFIEGGWAGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLEKRMENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKNQLRNNAKEIGNGCFEFYHKCNNECMESVKNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: SELA_YERPB
Sequence: MSAEPHPLYRQLPAIDRLLNEPEMAPLLAEYGPVLLADTLRQLQAEAREYIGQFHTLADWCADWPAALRQRLNQRQPALKPVFNLTGTVLHTNLGRAPLAESAIAAVTDAMRSAVTLEYSLEGAGRGHRDRAVADLLCALTGAEDACIVNNNAAAVFLLLTVMAAGKQVVVSRGELVEIGGAFRIPDVMRQAGCDLVEVGTTNRTHLKDYRQAINENTGLLMKVHTSNYSIEGFTAAVSEQQLAALGQECSIPTATDLGSGSLVDMTRYGLPAEPMPQQLIAAGVDLVTFSGDKLLGGPQAGIILGKKQWIERLQQHPLKRALRADKMTLAALDATLRLYQQPDRLVEQLPSLRLLTRPASEIAACAQRLLAPLIACYGTDFTLDIESCWSQIGSGSLPVDRLPSWALTFTPKDGRGSTLEALTARWRTLTKPVIGRVADGRLWLDLRCLEDEAALLRELAS
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPDA_ECOLI
Sequence: MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYSTRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG
What is the function of this protein?
May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins.  Can cleave N-acetyl-L-Ala(4).
What are the official names of this protein?
Oligopeptidase A.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
Protein: AROB_ECOLC
Sequence: MERIVVTLGERSYPITIASGLFNEPASFLPLKSGEQVMLVTNETLAPLYLDKVRGVLEQAGVNVDSVILPDGEQYKSLAVLDTVFTALLQKPHGRDTTLVALGGGVVGDLTGFAAASYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPASVVVDLDCLKTLPPRELASGLAEVIKYGIILDGAFFNWLEENLDALLRLDGPAMAYCIRRCCELKAEVVAADERETGLRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGMVMAARTSERLGQFSSAETQRIITLLTRAGLPVNGPREMSAQAYLPHMLRDKKVLAGEMRLILPLAIGKSEVRSGVSHELVLNAIADCQSA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_STRSY
Sequence: MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRNFIKKELADASTSTIEIERAVNKVIVSIHTAKPGMVIGKAGSNVDALRAQLNKLTGKQVHINIIEIKQPDLDAHLVGESIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEALTTYGKLGVKVWIYRGEVLPARKNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: MTRE_METAC
Sequence: MEPLIGMGVLALIGVAATIAGASEDLESDVGSQSNPNSQVQLAPQMMFPHRIFNKAVSGEPPSNALMCSVGAAVATVLISEFTLSPLFALVLGALIAACVHGTFAVTSTMGRAASQSRFKQPVYLDMIRSHTPVIMGYSFITTFCILVVSYLMTVVLGHPFPLTMLAFIWGITVGAIGSSTGDVHYGAEREFQQFEFGSGLNASNSGNIVRYGESGVRNGYDNSWFCAKFGGPVTGMAFGMTVFLGSWVTTVFDPAVSISRGWISVVAGVIIVLILIFWNWKIEVKARNAYGPYKEDKTEEASA
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit E, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E.
What is the protein family that this protein belongs to?
Belongs to the MtrE family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLSY_RUBXD
Sequence: MLEVLLVLLGYVLGSVPTGILVGRAYGVDVRKVGSGNIGTANVMRAAGKGAAALTMLGDMLKGVAPVLLARALGAGPWVLAAVALAAVVGHCWPVFLRFRGGKGVATGAGTSIALAPPVGLGMFALWWVVALASRYTSLAAMVVTVVSPFAFLLSGQPLPYVLYTVVGGAAVLWRHRENARALLRGTERKFGGRSGGGG
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CASB_BOVIN
Sequence: MKVLILACLVALALARELEELNVPGEIVESLSSSEESITRINKKIEKFQSEEQQQTEDELQDKIHPFAQTQSLVYPFPGPIPNSLPQNIPPLTQTPVVVPPFLQPEVMGVSKVKEAMAPKHKEMPFPKYPVEPFTESQSLTLTDVENLHLPLPLLQSWMHQPHQPLPPTVMFPPQSVLSLSQSKVLPVPQKAVPYPQRDMPIQAFLLYQEPVLGPVRGPFPIIV
What is the function of this protein?
Antioxidant peptide has antioxidant activity.
What are the official names of this protein?
Beta-casein.
What is the protein family that this protein belongs to?
Belongs to the beta-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: POLG_FCVF9
Sequence: MSQTLSFVLKTHSVRKDFVHSVKLTLARRRDLQYIYNKLSRTIRAEACPSCASYDVCPNCTSGDVPDDGSSTMSIPSWEDVTKSSTYSLLLSEDTSDELCPEDLVNVAAHIRKALSTQSHPANAEMCKEQLTFLLVMAEAMLPQRSRASIPLHQQHTAARLEWREKFFSKPLDFLLERVGVSKDILQTTAIWKIILEKACYCKSYGEQWFTAAKQKLREMKNFESDTLKPLIGGFIDGLRFLTVDNPNPMGFLPKLIGLVKPLNLAMIIDNHENTISGWIITLTAIMELYNITECTIDIITSVITAFYDKIGKATKFYSCVKALFTGFRSEDVANSFWYMAAAILCYLITGLIPNNGRFSKIKACLAGATTLVSGIVATQKLAAMFATWNSESIVNELSARTVALSELNNPTTTSDTDSVERLLELAKILHEEIKIHTLNPIMQSYNPILRNLMSTLDGVITSCNKRKAIARKRQVPVCYILTGPPGCGKTTAAQALAKKLSDQEPSVINLDVDHHDTYTGNEVCIIDEFDSSDKVDYANFVIGMVNSAPMVLNCDMLENKGKLFTSKYIIMTSNSETPVKPSSKRAGAFYRRVTIIDVTNPFVESHKRARPGTSVPRSCYKKNFSHLSLAKRGAECWCKEYVLDPKGLQHQSMKAPPPTFLNIDSLAQTMKQDFLLKNMAFEAEDGCAEHRYGFVCQQEEVETVRRLLNAVRARMNATFTVCVGPETSHSIGCTAHVLTPNETFNGKKFVVSRCNEASLSALEGNCVKSALGVCMSDKDLTHLCHFIKGKIVNDSVRLDELPANQHVVTVNSVFDLAWAVRRHLTLAGQFQAIRAAYDVLTVPDKIPAMLRHWMDETSFSDDHVVTQFVTPGGIVILESCGGARIWALGRNVIRAGGVTATPTGGCVRLMGLSAPTMPWSEIFRELFSLLGRIWSSVKVSALVLTALGMYASRFRPKSEAKGKTKLKIGTYRGRGVALTDDEYDEWREHNASRKLDLSVEDFLMLRHRAALGADDNDAVKFRSWWNSRTKMANDYEDVTVIGKGGVKHEKIRTNTLKAVDRGYDVSFAEESGPGTKFHKNAIGSVTDVCGEHKGYCIHMGHGVYASVAHVVKGDSFFLGERIFDLKTNGEFCCFRSTKILPSAAPFFSGKPTRDPWGSPVATEWKPKMYTTTSGKILGCFATTSTETHPGDCGLPYIDDNGRVTGLHTGSGGPKTPSAKLVVPYVHIDMKTKSVTAQKYDVTKPDISYKGLICKQLDEIRIIPKGTRLHVSPAHTEDYQECSHQPASLGSGDPRCPKSLTAIVVDSLKPYCENVEGPPHDVLHRVQKMLIDHLSGFVPMNISSETSMLSAFHKLNHDTSCGPYLGGRKKDHMANGEPDKQLLDLLSAKWKLATQGIALPHEYTIGLKDELRPVEKVSEGKRRMIWGCDVGVATVCAAAFKGVSDAITANHQYGPIQVGINMDSPSVEALFQRIKSAAKVFAVDYSKWDSTQSPRVSAASIDILRYFSDRSPIVDSASNTLKSPPVAIFNGVAVKVSSGLPSGMPLTSVINSLNHCLYVGCAILQSLEAKAIPVTWNLFSTFDIMTYGDDGVYMFPIMYASISDQIFGNLSSYGLKPTRVDKSVGAIEPIDPDSVVFLKRTITRTPQGIRGLLDRSSIIRQFYYIKGENSDDWKSPPKHIDPTSRGQQLWNACLYASQHGLEFFNKVYRLAERAVEYEELHFEPPTYASALDHYNSQFNGVEARSDQIDSSGMTALHCDVFEV
What is the function of this protein?
Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved.  Cleaves host translation initiation factor eIF4G1, eIF4G2 and PABP1 thereby inducing a shutdown of host protein synthesis.  This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap.  May cleave host polyadenylate-binding protein thereby inhibiting cellular translation.  It is also an RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals.  Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA.  This sgRNA codes for structural proteins.  Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
What are the official names of this protein?
Genome polyprotein.
Protein: WT1_HUMAN
Sequence: MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
What is the function of this protein?
Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533).  Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363).  Regulates the expression of numerous target genes, including EPO.  Plays an essential role for development of the urogenital system.  It has a tumor suppressor as well as an oncogenic role in tumor formation.  Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190).  Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801).  Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).
What are the official names of this protein?
Wilms tumor protein, WT33.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus speckle. SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm.
Protein: ATM1_NOVAD
Sequence: MPPETATNPKDARHDGWQTLKRFLPYLWPADNAVLRRRVVGAILMVLLGKATTLALPFAYKKAVDAMTLGGGAQPALTVALAFVLAYALGRFSGVLFDNLRNIVFERVGQDATRHLAENVFARLHKLSLRFHLARRTGEVTKVIERGTKSIDTMLYFLLFNIAPTVIELTAVIVIFWLNFGLGLVTATILAVIAYVWTTRTITEWRTHLREKMNRLDGQALARAVDSLLNYETVKYFGAESREEARYASAARAYADAAVKSENSLGLLNIAQALIVNLLMAGAMAWTVYGWSQGKLTVGDLVFVNTYLTQLFRPLDMLGMVYRTIRQGLIDMAEMFRLIDTHIEVADVPNAPALVVNRPSVTFDNVVFGYDRDREILHGLSFEVAAGSRVAIVGPSGAGKSTIARLLFRFYDPWEGRILIDGQDIAHVTQTSLRAALGIVPQDSVLFNDTIGYNIAYGRDGASRAEVDAAAKGAAIADFIARLPQGYDTEVGERGLKLSGGEKQRVAIARTLVKNPPILLFDEATSALDTRTEQDILSTMRAVASHRTTISIAHRLSTIADSDTILVLDQGRLAEQGSHLDLLRRDGLYAEMWARQAAESAEVSEAAE
What is the function of this protein?
Mediates the ATP-dependent export of glutathione-conjugated substrates, such as heavy metal-glutathione conjugates.  ATP hydrolysis is stimulated by glutathione binding.  Protects cells against toxic heavy metal ions, such as silver and mercury ions.  May also mediate the transport of glutathione-conjugated aromatic hydrocarbons, such as dinitrobenzene.
What are the official names of this protein?
ATM1-type heavy metal exporter, ATP-binding cassette transporter Atm1, NaAtm1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DBP9_COCIM
Sequence: MKRKLDENNVPTPENSGPKALEKTFETLHLDPRLLQALTKQKFTKPTLVQAEAIPLVLSGKDVLARAKTGSGKTAAYLLPILQSILQKKIANPTQKSISALILVPTRELAEQVQNAVVSFSSFCGKDIRSANLTQKVSDAVQRAILADLPDIIISTPARAIINTNSSSLSLNDLTHLVIDEADLVLSYGYEQDMQNLAKAIPRGVQTLLMSATLTSEVDALKGLFCRSPVILKLEEAEDEGAGIAQFAVKCAEDEKFLLTYVIFKLQLVKGKCIIFVGDIDRSYRLKLFLEQFGIKSCVLNSELPVNSRIHVVQEFNKGVYDIIIAADDQEVIGEIPKKGSKTPEQSNGENGDEPEEEKGFSDEDEVEPPPSKKRKKSTKEKDYGISRGIDFQDVACVLNFDLPTTAKSYTHRIGRTGRAGKTGMALSLIVPSELYGRHKPTSFPTAKNDEAVLAKIIKRQAKLGREVKPYNFDTKQIDAFRYRMTDALRAVTRVAVQEARTKEIKQELLNSEKLKRHFEENPEELRQLRHDGELRPTRVQAHLKHVPEYLMPAKGKAGLTSGDIGFVGLRKTNENRIRKARDRNRMRGKGGRKGGRGGGRKADPLKTFKSK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP9.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NOVN_STRNV
Sequence: MLILGLNGNVSAAGADVVPNLNELYMHDAAATLVRDGVLVAAVEEERLNRIKKTTKFPSNAIRECLAAAGAKPADVDAIAYYFPEDFFDDIFQQLYTEHPSVPTRYSREMILERLRVDLGWAAPPDILHYVPHHLAHAMSTYYRSGMREALVVVMDGAGERNCTTIYRSDGAELFEIASYPVPKSLGMFYLYGTRHLGYGFGDEYKVMGLAPYGDPSTYRDVFSTLYSLGPNGTYELIPRGGVVFRMTTILREHGLQPRRRGEPFTQAHMDFAASVQETTEQIAMHVIGYWARSTGLRNLAFGGGVAHNSTLNGRILTSGLFDEVFVHPASHDAGSSEGAALVVARERGERVWPLPRLTNASLGPDLGDVDSLERTLKSWSPLVDVERPDDIVEATAHLLAAGEAIGWAHGRSEFGPRALGNRSILADARPKENQTRINAMVKKRESFRPFAPVVTAEAAGDYFDLPETVGHHDFMSFVVQVRADRRELLGAVTHVDGSARVQVVTEETNPRFHRLVTRFGELTGTPVLLNTSFNNHAEPIVQSVDDVLTSYLTTSLDVLVIEDFVVRRRTELPLALEDFTIGFRPVTRLVRRLADVSAGRPGAPEVSHEIYLDHTSGPRATISAAMYELLTHADGVTPLGSLGIELTGELLTELYDLWQGRFVTVAPVGDGAGSAP
What is the function of this protein?
Carbamoyltransferase that mediates 3'-carbamoylation of the noviosyl ring to produce novobiocin, the final step in the novobiocin biosynthesis pathway.  Novobiocincin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases.
What are the official names of this protein?
Decarbamoylnovobiocin carbamoyltransferase, Novobiocin biosynthesis protein N.
What is the protein family that this protein belongs to?
Belongs to the NodU/CmcH family.