PharMolix/UniProtQA huggingface dataset:
Protein: SULA_ECOUT
Sequence: MYTAGYAHRDSSFSSTASKIARVSTENTTAGLISEVVYREDQPMMTQLLLLPLLQQLGQQSRWQLWLTPQQKLSREWVQASGLPLTKVMQISQLSPCHTVESMVRALRTGNYSVVIGWLADDLTEEEHAELVDAANEGNAMGFIMRPVSASSHATRQLSGLKIHSNLYH
What is the function of this protein?
Component of the SOS system and an inhibitor of cell division.  Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments.  In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring.  This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
What are the official names of this protein?
Cell division inhibitor SulA.
What is the protein family that this protein belongs to?
Belongs to the SulA family.
Protein: YAJG_ECOLI
Sequence: MFKKILFPLVALFMLAGCAKPPTTIEVSPTITLPQQDPSLMGVTVSINGADQRTDQALAKVTRDNQIVTLTASRDLRFLLQEVLEKQMTARGYMVGPNGPVNLQIIVSQLYADVSQGNVRYNIATKADIAIIATAQNGNKMTKNYRASYNVEGAFQASNKNIADAVNSVLTDTIADMSQDTSIHEFIKQNAR
What are the official names of this protein?
Uncharacterized lipoprotein YajG.
What is the protein family that this protein belongs to?
To H.influenzae HI_0162.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: MRAY_MYCSJ
Sequence: MRQILIAVGLALAVSILLTPVLIRLFTRQGFGHEIREDGPPTHHKKRGTPSMGGVAILAGIWVSYLGTHLVGLALDGEGPSASGLLVLGLATALGIVGFIDDLIKIRRARNLGLNKTAKTVGILAAALLFGVLALQFGNADGLTPGSPELSYVREIATVTLAPLIFVLFCVVLVSAWSNAVNFTDGLDGLAAGAMAMVCAAYVLITFWQYRNACATSPGLGCYNVRDPLDLALVAAAAAGACIGFLWWNAAPAKIFMGDTGSLALGGIIAGLSVTSRTEILAVVLGALFVAEVTSVVVQILAFRTTGRRVFRMAPFHHHFELVGWAETTVIIRFWLLTAIACGLGVALFYGEWLTAVGA
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HSPQ_YERE8
Sequence: MIASKFGIGQQVRHRLHGYLGVVIDIDPEYSLEPPAPDEVANNDTLRLSPWYHVVIEDDEGQPVHTYLAEAQLTYEDMDAHPEQPSLDELAASIRHQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCD_STAAN
Sequence: MSVFIDKNTKVMVQGITGSTALFHTKQMLDYGTKIVAGVTPGKGGQVVEGVPVFNTVEEAKNETGATVSVIYVPAPFAADSILEAADADLDMVICITEHIPVLDMVKVKRYLQGRKTRLVGPNCPGVITADECKIGIMPGYIHKKGHVGVVSRSGTLTYEAVHQLTEEGIGQTTAVGIGGDPVNGTNFIDVLKAFNEDDETKAVVMIGEIGGTAEEEAAEWIKANMTKPVVGFIGGQTAPPGKRMGHAGAIISGGKGTAEEKIKTLNSCGVKTAATPSEIGSTLIEAAKEAGIYESLLTVNK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit alpha, Succinyl-CoA synthetase subunit alpha, SCS-alpha.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase alpha subunit family.
Protein: SYS_CHLPD
Sequence: MLDITYVRQNLAEIESMLQNRQLASEKPRLRQLLEYDKNRRELVQRSDEMKAQRNKVSKEIADIKRTGQGSGEELIRQMKEVSDEITMMDATLSKLASDIEEILLSLPNRLHESVPTGKCAEDNVICKAPVPYLHLLDFPIKNHLELGRSLGILDFERGAKISGAGFPVYIGKGARLERALINFMLDYHTDHHGFTEVFPPFFVNQESLRGTGQWPKFADQVYHIEEDNLYAIPTAEVPVTNLHRNEMIDAERLPVSYVAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVKFTRPEESYQELEKILMSAEAILQALMIPYRVLLLCSGDISANATKCYDIEVWSPAEEKYLEASSCSNFEDYQARRMNIRFKADSRSKPEFVHTLNGSGLATSRLMVSLLEHYQNRDGSITIPEALRPYTGFTSIDQLTS
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_BURCM
Sequence: MLVLGIESSCDETGLALYDTQRGLLAHALHSQIAMHREYGGVVPELASRDHIRRALPLLEEVMAQSGTHRDDIDAIAFTQGPGLAGALLVGASIANALALAWNKPTVGIHHLEGHLLSPLLVDEPPPFPFIALLVSGGHTQLMRVTDVGVYETLGETLDDAAGEAFDKTAKLIGLGYPGGPEVSKLAETGTPGAVVLPRPMLHSGDLDFSFSGLKTAVLTQMKKFEAAKLDGEALERAKADLARGFVDAAVDVLVAKSLAALKQTKLKRLVVAGGVGANRQLRAALSAAAAKRGFDVHYPDLALCTDNGAMIALAGALRLGRWPEQANADYAFTVKPRWDLASLAR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPT_YERPA
Sequence: MDKLLDRFFNYVSFDTQAKANVKSVPSTQGQRKLAQALQQELLTLGFSHVTLSDHGCVMATLPANVSWPVPTIGFIAHLDTSPDFSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGHTLITTDGKTLLGADDKAGIAEIITAMVRLKHRNVPHGDIRIAFTPDEEVGKGAQFFNVAEFDAQWAYTVDGGGIGELEFENFNAASVAIKIVGNNVHPGSAKGVMVNALSLATRYHQELPVDETPECTEGYDGFYHLQSIKGTVERAEMHYIVRDFNRDSFEARKKNMVDIAKRVGKGLHRDCYIEIVIDDSYYNMREQIIKHPHIIELAQQAMLDCDITPIMKPIRGGTDGAQLSFKGLPCPNIFTGGYNYHGKHEFITLEGMEKAVAVIMRISELTAKRAKES
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1464_METJA
Sequence: MMVRVMRYKKVPVKKIVNKIIDECDVILLVLDARDPEMTRNRELEKKIKAKGKKLIYVLNKADLVPKDILEKWKEVFGENTVFVSAKRRLGTKILREMIKQSLKEMGKKEGKVGIVGYPNVGKSSIINALTGKRKALTGSVAGLTKGEQWVRLTKNIKLMDTPGVLEMRDEDDLVISGALRLEKVENPIPPALKILSRINNFDNSIIKEYFGVDYEEVDEELLKKIGNKRSYLTKGGEVDLVRTAKTIIKEYQDGKLNYYKVDLKKYGQDRERDISFITKYLKDFPFIEDAKMIVTHLKDFDGLYKKIKKPVLGSEEIDGNIVVVSFGEKTKDACRKKVENLCRERNIEVLSKFGDKIGANNIYVAVGKRVKE
What are the official names of this protein?
Uncharacterized GTP-binding protein MJ1464.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family.
Protein: GSPG_DICCH
Sequence: MERRQRGFTLLEIMVVIVILGVLASLVVPNLMGNKEKADKQKAVSDIVALESQLDMYKLDNSRYPTTEQGLGALVKKPTTPPEPRNYPQDGYIRRLPQDPWGAEYQLVSPGRHGKIDVFSYGPDGMPDTDDDIGNWNVGNGAHNNGGNGNGNP
What is the function of this protein?
Core component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Pseudopilin (pilin-like) protein that polymerizes to form the pseudopilus.  Further polymerization triggers pseudopilus growth.
What are the official names of this protein?
Type II secretion system core protein G, T2SS core protein G, General secretion pathway protein G, Pectic enzymes secretion protein OutG.
What is the protein family that this protein belongs to?
Belongs to the GSP G family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: KN7A_ARATH
Sequence: MTIKTPGTPVSKMDRTPAVTPGGSSRSREEKIVVTVRLRPMNKRELLAKDQVAWECVNDHTIVSKPQVQERLHHQSSFTFDKVFGPESLTENVYEDGVKNVALSALMGINATIFAYGQTSSGKTYTMRGVTEKAVNDIYNHIIKTPERDFTIKISGLEIYNENVRDLLNSDSGRALKLLDDPEKGTVVEKLVEETANNDNHLRHLISICEAQRQVGETALNDTSSRSHQIIRLTIQSTHRENSDCVRSYMASLNFVDLAGSERASQSQADGTRLREGCHINLSLMTLTTVIRKLSVGKRSGHIPYRDSKLTRILQHSLGGNARTAIICTLSPALAHVEQSRNTLYFANRAKEVTNNAHVNMVVSDKQLVKHLQKEVARLEAERRTPGPSTEKDFKIQQMEMEIGELRRQRDDAQIQLEELRQKLQGDQQQNKGLNPFESPDPPVRKCLSYSVAVTPSSENKTLNRNERARKTTMRQSMIRQSSTAPFTLMHEIRKLEHLQEQLGEEATKALEVLQKEVACHRLGNQDAAQTIAKLQAEIREMRTVKPSAMLKEVGDVIAPNKSVSANLKEEITRLHSQGSTIANLEEQLESVQKSIDKLVMSLPSNISAGDETPKTKNHHHQSKKKKLLPLTPSSASNRQNFLKSPCSPLSASRQVLDCDAENKAPQENNSSAARGATTPQGSEKETPQKGEESGDVSSREGTPGYRRSSSVNMKKMQQMFQNAAEENVRSIRAYVTELKERVAKLQYQKQLLVCQVLELEANDGAGYSVENEENTIMEDEEQNQVAWHITFIEERQQIIELWHVCHVSIIHRTQFYLLFKGDQADQIYMEVELRRLTWLEQHLAEVGNATPARNCDESVVSLSSSIKALRREREFLAKRVNSRLTPEEREELYMKWDVPLEGKQRKLQFVNKLWTDPYDSRHVQESAEIVAKLVGFCESGNISKEMFELNFAVPSDKRQWNIGWDNISNLLHL
What is the function of this protein?
Probable plus end-directed motor protein that functions in the NACK-PQR (ANP1-MKK6-MPK4) MAP kinase signaling pathway, which is essential for somatic cell cytokinesis, especially for the cell-plate formation and its expansion.  Regulates the activity and the localization of ANP1, probably by association through the non-catalytic region of the kinase.  Functionally redundant with NACK2 and essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during microgametogenesis and megagametogenesis.
What are the official names of this protein?
Kinesin-like protein KIN-7A, NPK1-activating kinesin-1, AtNACK1, Protein HINKEL.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-7 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, phragmoplast.
Protein: ACE_PANTR
Sequence: MGAASGRRGPGLLLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPVWQNFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRGGANPGFHEAIGDVLALSVSTPAHLHKIGLLDNVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPNSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYQSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARRFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHTNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQWLLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFDSEVELRHS
What is the function of this protein?
Isoform produced by alternative promoter usage that is specifically expressed in spermatocytes and adult testis, and which is required for male fertility.  In contrast to somatic isoforms, only contains one catalytic domain.  Acts as a dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of substrates (By similarity).  The identity of substrates that are needed for male fertility is unknown.  May also have a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.  The GPIase activity was reported to be essential for the egg-binding ability of the sperm.  This activity is however unclear and has been challenged by other groups, suggesting that it may be indirect (By similarity).
What are the official names of this protein?
Angiotensin-converting enzyme, ACE, Dipeptidyl carboxypeptidase I, Kininase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase M2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Detected in both cell membrane and cytoplasm in neurons. SUBCELLULAR LOCATION: [Angiotensin-converting enzyme, soluble form]: Secreted. SUBCELLULAR LOCATION: [Isoform Testis-specific]: Cell membrane; Single-pass type I membrane protein. Secreted. Note=The testis-specific isoform can be cleaved before the transmembrane region, releasing a soluble form.
Protein: RGS8_RAT
Sequence: MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
What is the function of this protein?
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2.  Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.  Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.
What are the official names of this protein?
Regulator of G-protein signaling 8, RGS8.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, dendrite. Nucleus. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1.
Protein: GUAAA_METTH
Sequence: MFMILIINNHGQYNHRIHRTLRYLQIPSELVPNTTPLDEIISRDPEGLILGGGPSLERSGNCVEYIQKLEIPILGICLGHQLIAKAYGGEVATAEAESYAQIELEILDEDDIFRGLGPRMSVWASHKDEVKKLPDEFDVLATSSICEVEAMKHHDKPVYGIQFHPEVHHTREGHRVFENFYDVCRS
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: WAPL_HUMAN
Sequence: MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPKKPKVEEESTGDPFGFDSDDESLPVSSKNLAQVKCSSYSESSEAAQLEEVTSVLEANSKISHVVVEDTVVSDKCFPLEDTLLGKEKSTNRIVEDDASISSCNKLITSDKVENFHEEHEKNSHHIHKNADDSTKKPNAETTVASEIKETNDTWNSQFGKRPESPSEISPIKGSVRTGLFEWDNDFEDIRSEDCILSLDSDPLLEMKDDDFKNRLENLNEAIEEDIVQSVLRPTNCRTYCRANKTKSSQGASNFDKLMDGTSQALAKANSESSKDGLNQAKKGGVSCGTSFRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHETGGDEGGSGSSNYKIKYFGFDDLSESEDDEDDDCQVERKTSKKRTKTAPSPSLQPPPESNDNSQDSQSGTNNAENLDFTEDLPGVPESVKKPINKQGDKSKENTRKIFSGPKRSPTKAVYNARHWNHPDSEELPGPPVVKPQSVTVRLSSKEPNQKDDGVFKAPAPPSKVIKTVTIPTQPYQDIVTALKCRREDKELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDEDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLPHQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSGEGDDSLRIGGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGTEEKHKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKFLSFMNLTCAVGTTGQKSISRVIEYLEHC
What is the function of this protein?
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin.  Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis.  Couples DNA replication to sister chromatid cohesion.  Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
What are the official names of this protein?
Wings apart-like protein homolog, Friend of EBNA2 protein, WAPL cohesin release factor.
What is the protein family that this protein belongs to?
Belongs to the WAPL family.
Protein: MPTA_METBU
Sequence: MELPIAQFPDVQANRPKIPINLTRVGVTGVKKLVEIKRKDKRPIVLISTFEIFVDLPSDRKGANLSRNFEAMDEVLEKAINLPVYEIEKLCNDVAKSLLRRHEYATRSEVRMKSEYVVKREAPSTKMKCQEVVDIFAEATATRLEDGDIDVKKLIGAEVVGMTACPCAQEIMRDNAKTALRELGVGLETVMNFLNKVPMATHNQRGRGIISLEVSGDVDVSLETIIRIIESSMSSSIVELLKRADEALVVERAHQNPKFVEDCVRTMAQNIVSEFAHVPDSALVTIKQINEESIHRHNAFAERVALLGDLRDEIKNN
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: INO1A_XENLA
Sequence: MAEKFKVESPHVRYLKDVIEADYNYDTTQVYEEKGVTKVKPCSTKFTFHTERKVPKLGVMLVGWGGNNGTTVTAAVLANRLGLSWMTKTGKKVANYYGSLFQSSTACLGSGPAGDVFVPFRDLLPMVHPNDIVFDGWDISSLNLADAMFRAEVLDWQIQEQLRPYMEKMKPRPSIYIPDFIAANQEDRADHTIHGTKAEQVQKIREDIQDFKRTSDVDKVIVLWTANTERFCDIIPGVNDTADNLLKAIENGLEVSPSTMFAVASILEGCAYINGSPQNTFVPGAIELAVQNNVFIGGDDFKSGQTKIKSVLMDFLVSAGLKPVSIVSYNHLGNNDGKNLSAPQQFRSKEISKSNVVDDMVQSNPILYGPNEKPDHCVVIKYVPYVGDSKRAMDEYTSEIMMGGANTIVLHNTCEDSLLASPIILDLVLLTELCQRITFRTETDQEFQTFHSVLSILSFLCKAPLVPAGTPVINAFFRQRNCIENILRACLGLSPQNHMMLEHKMQRSFVSLKRPSTVCNPQPISSKKGNNANGFHLPGISKGLSQSNGLGKNVINSDIEIEN
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner.  Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).
What are the official names of this protein?
Inositol-3-phosphate synthase 1-A, IPS 1-A, Myo-inositol 1-phosphate synthase A, MI-1-P synthase A, MIP synthase A.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_BUCAT
Sequence: MKIKKKYCGHVIIVGKANVGKSTLLNNIIGKKISIVSRKKNTTQSNITGIKTEDNYQSIYIDTPGVVFDKNNNQMKHHKNNFYQTTQIATLIIFIIDRIDWTIHDEIILNEIKKTKIPILIIINKIDKISNKIILLPFINFLKKKIDFIEILPISAKKISNLILLKNIIKSYLPENCHIYPECYVTTNSDFFTVSEIIREQLILFLGDELPSIIKVEIESFKKKEKIALYIKAIIWVKNVRQKSIVIGHNGEKIKKISMISRNNIEKKFYIKTHLVLWVKDKN
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: IQCM_HUMAN
Sequence: MTTEEAMPEKAKCPTLEITKQDFFQEAKTLIAQHYEKINENKVQGTSINVFRKKHQKPKSGKYIPLEIDKKVTRDVVQEHRAALRRICFPKELSKSEHLQEPPQRISFKEPHIFSRRERCRPIDLITKGQVKLDKIMTIIEPVSKKMETAKQQHFEESRNRMLELLYPFPVHLYLQPGTSNLELLKEPDKAFYDWRGFVLTRSFRLACDSRRVSFSQSSSIFRDYYSKTFKTLIKKERQPIKPEPKSQPRIKGTPNKTDKLDSKVKRIGPHIEIFQVFRERKKFMITPKLIRMVTVMQAHVRGWLERKRLQRVMTKALDHGPDMKAVINMYGRLIHRVRYRRGLWRTRQILNLAELEEWMDRKKFYEIMFAKREDWPKIERNELPNFFSDCGHFPTQKQVDDTWDLVHQDGKEKYSELIKKSKAIEMLFTLYPPEGAHVPDSTLLKSTWLRPIVNGEEGYRYIVNGHPALKRANIRVVGKLVARSIRERKMRQHYKSCKVE
What are the official names of this protein?
IQ domain-containing protein M.
Protein: PELO_THEGJ
Sequence: MQILEEKPKEGIVKVKAETLDDLWHLYHVIDPGDVVYAKTLRKQAQRSDSLRAEKVEVIPVYLGVKAEKINFHKFANQVRVTGPIVYASRDDVPLGKYHTITIEEGTVVTIQKPRWKEHHIERLKEAIEASKRAKVMIVVIDEGEADIALVREYGVEMVASIRRNLGGKRYNTDRESEEKRFFHDLAKTMAELMEREKIEKAIVAGPGFVKEDFHKFLRENYPELAKKVVIEDTSVTGRTGIYEVIKRGTVDRVYHENRVAKEVQLVEKVLEHVARNTGLATYGLREVEEAVNYGAVETLLVLDELLKGEHRERIEELMDAVRYARGEVVIVSSEHEGGEKLKALGGLAALLRFRVK
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JUN_MOUSE
Sequence: MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
What is the function of this protein?
Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:14707112).  Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (PubMed:2498083).  Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity).  Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646).  Involved in activated KRAS-mediated transcriptional activation of USP28 (By similarity).  Binds to the USP28 promoter (By similarity).
What are the official names of this protein?
Transcription factor Jun, AH119, Activator protein 1, AP1, Proto-oncogene c-Jun, Transcription factor AP-1 subunit Jun, V-jun avian sarcoma virus 17 oncogene homolog, Jun A.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Jun subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: BACD1_DANRE
Sequence: MSAEASGSSGGHAVTVSGSSPSSSSHVGEEKPGRSLVSSKYVKLNVGGTLHYTTVQTLSKEDSLLRSICDGSTEVSIDSEGWVVLDRCGRHFSLVLNFLRDGTVPLPDSTRELEEVLKEAQYYRLQGLVQHCLSTLQKRRDVCRGCHIPMITSAKEEQRMIATCRKPVVKLQNNRGNNKYSYTSNSDDNLLKNIELFDKLGLRFNGRVLFIKDVLGDEICCWSFYGEGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYENGRGSGGMALLESGGVSSSGAGQSEEEGAGAGGGDRRVRRIHVRRHIMHDERGHGQQTVYKD
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (By similarity).  The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission (PubMed:29088697).
What are the official names of this protein?
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1, BTB/POZ domain-containing protein KCTD13.
What is the protein family that this protein belongs to?
Belongs to the BACURD family.
What are the subcellular locations of this protein?
Nucleus.