PharMolix/UniProtQA huggingface dataset:
Protein: RNC_CLOK1
Sequence: MEKVNFFEEVEKTLNISFNDKELIDTALTHSSYANGKKGVKFNERMEFLGDSVLQLCISEYLFLIYKSKSEGELTKKRSLIVCENSLYEVAKKWNIGKYIKMSKGEEITGGRERTSILANCVEAIIAAIYIDSGYKKTKQFIIDNFKDIIEKAIKNQIVLDYKTNLQEIVQQDGDIHIEYMLIKYEGPPHRRKFYTKVCVANNVMGSGVGYTKKESEQNAAQDALKKLKSEDKWNKEGIDTNEK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GALE_NEIMA
Sequence: MKNILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDIRDREILRRIFAENRIDSVIHFAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFSIVFSSSATVYGDPGKVPYTEDMPLGDTTSPYGTSKSMVERILTDIQKADPRWSMILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDLAEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD
What is the function of this protein?
Involved in the metabolism of galactose.  Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis.  Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
What are the official names of this protein?
UDP-glucose 4-epimerase, Galactowaldenase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: LEXA_AFIC5
Sequence: MLTRKQYELLRFINERLKESGIPPSFDEMKDALDLRSKSGIHRLITALEERGFIRRLANRARAIEVIKLPEPALGSGGRRGFTPSVIEGNLGKARGPASFDESGEQPVAVPVMGRIAAGTPIEALQTRSHTISVPPDMLGAGEHYALEVRGDSMVEAGILDGDMALIQRSENADTGDIVVALIDEEEATLKRFRRRGASIALEPANTAYEVRILPPNRVRIQGKLIGLYRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: EID1_PONAB
Sequence: MSEMAELSELYEESSDLQMDVMPGEGDLPQMEVGSGSRELSLRPSRNGAQPQLEEEGPMEEEEAQPMAAPEGKRSLASGPNAGEQPGQVAGADFESEDEGEEFDDWEDDYDYPEEEQLSGAGYRVSAALEEADKMFLRTREPALDGGFQMHYEKTPFDQLAFIEELFSLMVVNRLTEELGCDEIIDRE
What is the function of this protein?
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation.  Inhibits EP300 and CBP histone acetyltransferase activity.  May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation.  May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity).
What are the official names of this protein?
EP300-interacting inhibitor of differentiation 1, E1A-like inhibitor of differentiation 1, EID-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=May shuttle between nucleus and cytoplasm.
Protein: NODB_HYPPI
Sequence: MDGFDRSNAPVEYQRVEWISDIFVFGMGVCWLINYAGMIYTSLQEQTYSMAPLALCCNFAWEMVYGLIYPSKSRIEQGVFLAGLVVNLGVMYTAIRFAPNEWAHAPLVMNNITLIFALGVLGSLTGHLALAAEIGPALGYSWGAVACQLLLSVGGFCQLLGRSSSRGASYTLWLSRFIGSGCVVGFAILRYMYWSEAFNWLNSPLVLWSLGVFIAVDSLYGICLWNVKKYEHGQERSNARKAQ
What is the function of this protein?
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes nodulisporic acids (NA).  Nodulisporic acid A (NAA) and its chemically modified derivatives are of particular significance because of their highly potent insecticidal activity against blood-feeding arthropods and lack of observable adverse effects on mammals, in particular the tremogenicity associated with the paspaline-derived IDTs is not observed (PubMed:29283570).  The geranylgeranyl diphosphate (GGPP) synthase ggs1, localized outside of the cluster, is proposed to catalyze the first step in nodulisporic acid biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:29283570).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase nodC then forms 3-geranylgeranylindole (3-GGI) (PubMed:29283570).  Epoxidation by the FAD-dependent monooxygenase nodM leads to a single-epoxidized-GGI that is substrate of the terpene cyclase nodB for cyclization to yield emindole SB (PubMed:29283570).  The terminal methyl carbon, C28, of emindole SB is then oxidized by the cytochrome P450 monooxygenase nodW to produce nodulisporic acid F (NAF), the pentacyclic core of NAA (PubMed:29283570).  NAF is converted to nodulisporic acid E (NAE) via prenylation.  This step is probably performed by one of the indole diterpene prenyltransferases nodD1 or nodD2 (Probable).  Several oxidation steps performed by the FAD-linked oxidoreductase nodO and one of the cytochrome P450 monooxygenase nodR, nodX or nodZ further convert NAE to nodulisporic acid D (NAD) (Probable).  NAD is substrate of cytochrome P450 monooxygenase nodJ to produce the precursor of nodulisporic acid C (NAC), converted to NAC by one of the indole diterpene prenyltransferases nodD1 or nodD2 (Probable).  The FAD-dependent monooxygenase nodY2 then oxidizes NAC to nodulisporic acid B (NAB) (Probable).  Finally NAB is converted to NAA by one of the cytochrome P450 monooxygenases nodR, nodX or nodZ (Probable).
What are the official names of this protein?
Terpene cyclase nodB, Nodulisporic acid biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BLT3A_HUMAN
Sequence: MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGQLTNLELDEEVLQNVLELPTWLAITRVYCNRASIRIQWTKLKTHPICLCLDKVEVEMKTCEDPRPPNGQSPIALASGQSEYGFAEKVVEGMFIIVNSITIKIHSKAFHASFELWQLQGYSVNPNWQQSDLRLTRITDPCRGEVLTFKEITWQTLRIEADATDNGDQDPVTTPLRLITNQGRIQIALKRRTKDCNVISSKLMFLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAHQRKSLAPEPVQITPPAPSAQQSWAQAFGGSQGNSNSSSSRLSQYFEKFDVKESSYHLLISRLDLHICDDSQSREPGVSANRLMGGAMQLTFRKMAFDYYPFHWAGDSCKHWVRHCEAMETRGQWAQKLVMEFQSKMEKWHEETGLKPPWHLGVDSLFRRKADSLSSPRKNPLERSPSQGRQPAFQPPAWNRLRSSCMVVRVDDLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPTQVSAIHIEFTEYYFPDNQELPVPCPNLYIQLNGLTFTMDPVSLLWGNLFCLDLYRSLEQFKAIYKLEDSSQKDEHLDIRLDAFWLKVSFPLEKRERAELHRPQALVFSASGMIATNTRHAPHCSCSDLQSLFRGFAAAEFFHSNYDHFPKVPGGFSLLHMLFLHHAFQMDSCLPQPNTLPPQRPKASWDLWSVHFTQISLDFEGTENFKGHTLNFVAPFPLSIWACLPLRWQQAQARKLLLASEGRLKPSASFGSPVQSEALAPDSMSHPRSKTEHDLKSLSGLTEVMEILKEGSSGMDNKGPLTELEDVADVHMLVHSPAHVRVRLDHYQYLALLRLKEVLQRLQEQLTKDTESMTGSPLQNQTACIGVLFPSAEVALLMHPAPGAVDADSAGSDSTSLVDSELSPSEDRELKSDASSDQGPASPEKVLEESSIENQDVSQERPHSNGELQDSGPLAQQLAGKGHEAVESLQAKKLSRTQASSSPAALKPPAGRETAVNGQGELIPLKNIEGELSSAIHMTKDATKEALHATMDLTKEAVSLTKDAFSLGRDRMTSTMHKMLSLPPAKEPMAKTDEGVAAPVSGGAARLRFFSMKRTVSQQSFDGVSLDSSGPEDRISVDSDGSDSFVMLLESESGPESVPPGSLSNVSDNAGVQGSPLVNNYGQGSPAANSSVSPSGEDLIFHPVSVLVLKVNEVSFGIEVRGEDLTVALQAEELTLQQLGTVGLWQFLHGQCPGTCFQESSTLKTGHIRPAVGLRFEVGPGAAVHSPLASQNGFLHLLLHGCDLELLTSVLSGLGPFLEDEEIPVVVPMQIELLNSSITLKDDIPPIYPTSPGPIPITLAMEHVVLKRSDDGVFHIGAAAQDKPSAEVLKSEKRQPPKEQVFLVPTGEVFEQQVKELPILQKELIETKQALANANQDKEKLLQEIRKYNPFFEL
What is the function of this protein?
Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567).  May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567).
What are the official names of this protein?
Bridge-like lipid transfer protein family member 3A, ICBP90-binding protein 1, UHRF1-binding protein 1, Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1.
Protein: RL24_POLAQ
Sequence: MKKIRKGDSVVLLTGRDKGKQGTVTAVLENKLVIEGVNIYKKSVKPNPAAGVTGGMIDKTMPVHISNVAVVDGNGKPSRVGIKLVDGKKQRFLKTTGATLSA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PCKA_STAAM
Sequence: MSVDTYTETTKIDKLLKKPTSHFQLSTTQLYNKILDNNEGVLTELGAVNASTGKYTGRSPKDKFFVSEPSYRDNIDWGEINQPIDEETFLKLYHKVLDYLDKKDELYVFKGYAGSDKDTMLKLTVINELAWHNLFAKNMFIRPESKEEATKIKPNFTIVSAPHFKADPEVDGTKSETFVIISFKHKVILIGGTEYAGEMKKGIFSVMNYLLPMQDIMSMHCSANVGEKGDVALFFGLSGTGKTTLSADPHRKLIGDDEHGWNKNGVFNIEGGCYAKAINLSKEKEPQIFDAIKYGAILENTVVAEDGSVDFEDNRYTENTRAAYPINHIDNIVVPSKAAHPNTIIFLTADAFGVIPPISKLNKDQAMYHFLSGFTSKLAGTERGVTEPEPSFSTCFGAPFFPLHPTVYADLLGELIDLHDVDVYLVNTGWTGGKYGVGRRISLHYTRQMVNQAISGKLKNAEYTKDSTFGLSIPVEIEDVPKTILNPINAWSDKEKYKAQAEDLIQRFEKNFEKFGEKVEHIAEKGSFNK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_SHEB8
Sequence: MAAKEVVFGNDARVRMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVVEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKALSQPCADSKAIAQVATISANSDESIGEIIATAMEKVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGLAKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTVIAEEIGLELEKATLEDLGTAKRVVITKDNTTIIDGNGEQTQIAARVSQIKQQVEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALVRVASKIADVEVLNEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANTVKNGSGNYGYNAGNDTYGDMLEMGILDPTKVTRCALQFAASIAGLMITTEAMVAEIPQNASQDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAPR_STAAW
Sequence: MKLKKDKRREAIRQQIDSNPFITDHELSDLFQVSIQTIRLDRTYLNIPELRKRIKLVAEKNYDQISSIEEQEFIGDLIQVNPNVKAQSILDITSDSVFHKTGIARGHVLFAQANSLCVALIKQPTVLTHESSIQFIEKVKLNDTVRAEARVVNQTAKHYYVEVKSYVKHTLVFKGNFKMFYDKRG
What is the function of this protein?
Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.
What are the official names of this protein?
Transcription factor FapR, Fatty acid and phospholipid biosynthesis regulator.
What is the protein family that this protein belongs to?
Belongs to the FapR family.
Protein: RL24_AMOA5
Sequence: MYNKHHKTLKLHIKKGDTVQVLSGNYRKKQGTVLKVFPKTYRAIVEGVHIVSKHKKPTAKNPQGTIEKVEAPIHISNLMLIESATSRPTRIGRKLDEEGKLQRYSKKTGEFIKNG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: TRPR_KLEP3
Sequence: MTQQSPYSAAVAEQRHQEWLRFVALLQQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKNELGAGIATITRGSNSLKSAPAELRQWLEQTLLTSDK
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_CHRSD
Sequence: MTRVKRGVVARRRHKKILKQAKGYYGARSRVFRVAKQAVIKAGQYAYRDRRQRKRQFRALWITRINAASRANGLSYSRFIAGLKKSGIEIDRKVLADLAVHEKAAFAAIVDKAKAAQ
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RS13_ALIB4
Sequence: MARIAGVDLPNKKRMEYALTYIYGIGLHNSRLILNAVGIDFNKRAFELTEDEAAAIRKEIQENYMVEGDLRKKVAMDIKSLMDLGSYRGLRHRKGLPCRGQKTKTNARTRKGKKKTVGAATK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: CYC6_DIALT
Sequence: GDIANGEQVFTGNCAACHSVZZZKTLELSSLWKAKSYLANFNGDESAIVYQVTNGKNAMPAFGGRLEDDEIANVASYVLSKAG
What is the function of this protein?
Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis.
What are the official names of this protein?
Cytochrome c6, Cytochrome c-553, Cytochrome c553, Soluble cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family. PetJ subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: BEFA_AERVE
Sequence: MNKRNWLLALSLSLAFSPCYADWAKLKAAASDLGAAVSETSKEVWQDVSDFSKKSWASISAWGEEAFNTAGVWTDKSIATGKEWLKAADKELNEMLNPKTAKEARIAINTMADTALIRLFNEQPSAKLLFDKAYGYAVFDSRKFSLMLHTNQGAGVAVNRKTGKHTYMKMFGAGLAAGIGGKFYQQVILFEDKARFDAFVTQGWEATSEVGVVAGKESAELTAKYNGGMAIYQIGEKGLLLDANISGSKYWIDKDLTETSR
What is the function of this protein?
Stimulates the proliferation of insulin-producing beta cells during development in gnotobiotic zebrafish and mice (PubMed:27960075, PubMed:36240759).  BefA is a microbiome-derived protein that traffics from the host intestinal lumen to the pancreas to act directly on pancreatic islets (PubMed:36240759).  In pancreas, interacts directly with host beta cells and elicits their proliferation via a mechanism of increasing membrane permeabilization (PubMed:36240759).  Can also permeabilize bacterial cell membranes, but does not show killing of target bacteria (PubMed:36240759).
What are the official names of this protein?
Beta cell expansion factor A.
Protein: DHE4_LACBS
Sequence: MVLPVEPEYEQALSELQNSLKPFLAANPDYEKALEIVQIPERVLQFRVVWEDDQGKAQVNRGFRVQYNSALGPYKGGLRLHPSVNLSILKFLGFEQTFKNALTGLSMGGGKGGSDFDPKGKSDGEIRRFCTSFMSELFRHIGQDTDVPAGDIGTGAREIGYLFGAYKKLQNEFVGMLTGKGLAWGGSFIRPEATGYGLIYYVEHMIAKAAPEYSLSKPETLVAISGSGNVAQFTALKVIELGATVLSLSDSKGSLIAEKGYTKEFIKEIGQLKLKGGALESLAQREGYTYHAGKRPWSLLPVVHVALPGATQNEVSKTEAEDLIKAGVRIVAEGSNMGCTEDAIAVFEASRKAGAGGVWYAPGKASNCGGVAVSGLEMAQNSQRLAWTTDQVDQKLKKIMAECYEICLSAGTKWSGEEIKDGVLPSLLSGANVAGFIKVADAMREHGDWW
What are the official names of this protein?
NADP-specific glutamate dehydrogenase, NADP-GDH, NADP-dependent glutamate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: SECB_EHRCR
Sequence: MSCKLKVKGQYIKDLSFENPNSPQIFLMISKTPPEINISINVSSVSLPVKAQDQSSEQPSDNKVEPLYEVTLQVNAEARVGTTVAFICEIKYCGVFSIESDDVSIEELSQQDIRDVLLISAPTILFPFVRELISRVTSTGGFPPLMLDIVDFRAMYESQMKQGVGQNDNSQDPEK
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_METTP
Sequence: MGKRIISQNRGKGTPTYRAPSHRYRADIKHIKFSGDLVRGIVEDIMHDPARTAPVALVRLENGEKQYVLATEGTYIGQEIACGPAAEIQPGNTLPLASIPEGMPICNIESKPGHGGQFARASGVYGILVAHDVGATVVQLPSGEMKWLNPNCLATIGVVAGGGRTEKPLVKAGKSFYKYRSKAVKWPRVRGVAMNAVDHPFGGGGRQHPGRPKTVSRGTPPGRKVGSIAARRTGKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PB1F2_I77A4
Sequence: MEQEQDTPWTQSTEHINIQKKGSGQQTQRLGRPNSTQLMDHYLRIMSQADMHKQTVSWKQWLSLKNPTQGFLKTRALKRWKSFNKQGWTN
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: RASK_RAT
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQELARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCVIM
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity).  Plays an important role in the regulation of cell proliferation (PubMed:3110778).  Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).
What are the official names of this protein?
GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Endomembrane system. Cytoplasm, cytosol. SUBCELLULAR LOCATION: [Isoform 2B]: Cell membrane; Lipid-anchor.
Protein: DCDB_MYCLE
Sequence: MLLSDRDLRAEITAGRFSIDPFDDTLVQPSSIDVRLDCMFRVFNNTRYTHIDPARQQDELTSLVELVDGEPFVLHPGGFVLGSTLELFTLPEDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFCGHITLELSNVANLPITLWPGMKIGQLCVLRLTSPAEHPYGSASAGSKYQGQRGPTPSRSYENFIKNT
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RL30_THEM4
Sequence: MKKLKITLVKSPIGYKYDQKDTVKRLGLRKLNSTVIKEDVPQVRGMIRKVRHLVKVEEIEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: GRCA_PSYIN
Sequence: MIQGIQITKSDNENLLNSIWLIDNEKNEARCLVAPAQYKEDQVVPASELGEYESREVAIEAPKAQEGGQHLNVNVLKRETLEDAIKHPENYPQLTIRVSGYAVRFNSLTPEQQQDVLTRTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: NTPP_HELPH
Sequence: MELILGSQSSARANLLKEHGIKFEQKALYFDEESLKTTDPREFVYLACKGKLEKAKELLANNCVIVVADSVVSVGNRMQRKAKNKQEALEFLKRQNGNEIEVLTCSALISPVLEWLDLSVFRARLKAFDPSEIEKYLESGLWQESTGCVRLEDFHKPYIKSSSKNLSVGLGLNVESLLGVLKLGAKLSSL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3258_PHOPR
Sequence: MQLMVVSGRSGSGKSVALRVLEDLGYYCVDNLPVTLLPQFISTVENNEQDIAVSIDVRNMPSESGVIQKTLNSLDDKLDINVIFIDADDKELVKRYSETRRLHPLSKHDMSLEQAIQSESAIVADIKEHADLVIDTTNKSIHDLSETVRARVLGRESRKLILVFESFGFKHGLPTDADYVFDVRFLPNPHWVPELKPQTGLDQEVKEFLVGHAEVNKLIYQIRNFIETWLPLLEKNNRSYLTVAIGCTGGQHRSVYVAQQLADHFLHDGQQVQIRHRTLESK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein PBPRA3258.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: RPOC1_SYNP6
Sequence: MAKQEQRFDYVKIALASPERIRQWGERTLPNGQVVGEVTKPETINYRTLKPEMDGLFCEKIFGPAKDWECHCGKYKRVQHRGIVCERCGVEVTEPRVRRHRMGFIKLAAPVAHVWYLKGIPSYIAILLDMPLRDVEQIVYFNSYVVLNPDNHSELQYKQLLNEDQWMEIEDQIYAEESDLEGIEVGIGAEALQQLLQDLNLNEESEKLRQEIAESKGQKRAKLIKRLRVIDNFIGTESRPEWMVLNVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPNLKIHQCGLPREMAIELFQPFVIHRLIKNHSINNIKQAKKLIQKNDPLIWDVLEEVIEGHPVMLNRAPTLHRLGIQAFEPILVEGRAIQLHPLVCPAFNADFDGDQMAVHVPLSIEAQAEARMLMLASGNILSPATGQPIVTPSQDMVLGCYYLTAENPGAQKGAGRYFANLEDAIRAFEQGSVDLHAWVWVRFDGEVESEGESDEPESVVAADDGTVTKTYRFRRIRETEDGQRLSQYVKTAPGRILFNNTVQTALIH
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.