Protein: ORYA_ASPOR
Sequence: MVQRKDPPSEQLRAYTLLIELLSYQFAFPVRWIETQNDLIQRNNTIQRFVEVGPSNVLANMAKKTAKGQYAEEDLVRCVDRQYLSHADDAQHIYYQYDEEAPVESADNEPAQPAASSTPAAPAPVAAPPVVVQTAPQPAAQAAVAVPDVDLSAIDVVISIVAQKIRKAFDEVPAAKSIRDLSAGKSTLQNELIGQLDAEFRGLPEGSEDLALEALASHFTNFSGRPGKVMGGHIDRLVAARMPAGFNQAKIRDYLSSHWGLGLNRQTTVLCYAVTMEPAARLADAGQATQFLDSVVSRYGGKAGIALQKRAEGGASQTSAVAQVDLASLETLKKEQNEYLHKQFQLLAKHLDLDGVAQPSQTQVQGEDTDRLAEWDAEFDEEFLTGMRTIFDPRKARRYDSWWNTAREDLMALLHDIRPAAEDKASQRYQSLVNRWSPELEQMLEHSAQDDTTKEKAQMLLDDVRASGVANGPVFRYTQPAMAPETKVDANGRIQYSEVPRRQLHGENKASTLNYAQVVAARHRDVPYAHLRSRAGVDWKYDDQLTDMFLNILSTGASTGLSFTGRRVLVTGAGVGSIGADIVAGLLAGGAHVIVTTSRQPSDVAASFRQLYAKVGAPGSELIVLPFNQASKRDCEELINHIYDEQSGYGWDLDFIIPFAAISEIGRQIDKIDSKSELAHRAMLVNLLRLLGFIKQQKEKRGFDCRPTGVLLPLSPNHGNFGGDGLYSESKLGLETLFNRFHSEGWSDFLCIIGAVIGWTRGTGLMSANNIVAQGMEDSLDILTFSAPEMAFNILSLLSGDILEVADDEPIYADLSGGLQGVSDLKDKISAIRKKIVSDSRIRQALVAENLHEQKVLRGTKPAEGNVQPPLKRRSNIEPAFPPLSDYNSVTAGLQSLKGMVDLSRTVVVVGYSELGPWGSSRTRWEMEHEGRLSLEGYTELAWMMGLIKHFDGDLKGKPYTGWVDSKTKEAVDEADIEEKYGQHILGHAGIRVIEPELSEGYDPSQKEIMHEVVIDEDLPPFEAPQGVAQAFKLRHGDKVILTPIEGSESVKVVVKSGAVFMVPKAMAFNRFVAGQLPSGWDPTRYGIPEDIVAQVDPMTVYVLCCVSEAMYSAGLEDPFELYRHIHVSELANCVGTGAGGLLAMRGVYRDRYLDRPVQSDILQESFLNAMNAWTNMLLMGAAGPIKSPSGTCATSVESMDIACEAIQTLKAKVAIVGGSDDFQEEMSYEFGNMKATANAEDELEKGYLPSEMSRPTASSRSGFVESAGCGIQLVMSAELALQMGLPIYGIVAYSQMAGDKVGRSVPAPGQGVLTAARESIDAAQSPLLDVQYRKARLDEAVSEIKRWRHKESQKLIASTTSKEFKDLDAHLQHINNIAATRIRDAQWTWNNNIRHIDPTIAPMRAALATWGLSVDDIQVASFHGTSTKANDKNESNVINQQMTHLSRTVGNPLLVICQKSLTGHPKGAAGAWMFNGCLQALQTGIVPGNRNADNVDVALQQFKHLVYPSQTIHTSGIKAFMLTSFGFGQKGGLVVGIAPRYLFSTITANKFEDYRERVLQRQQKIIPVFQRRMAQGRLFQIKDQSAWTSDQEKDVFLNPQARVAQKSTGEYSFPTTVAPVASSLPARTVSDDKQLFARSSDQWLRDSISKEQGNVSVGVDIESISSVNIEDEIFLERNFTPGELKYCQGSPDKQASLSGRWAAKEAIFKSLQIPSEGAGAAMRDIEIVSNGAQPPTVLLHNRAKSAADAQKVEEVQVSITHSPESAMAIALARRRL
What is the function of this protein?
Fatty acid synthase alpha subunit; part of the gene cluster that mediates the biosynthesis of oryzines, natural products with an unusual maleidride backbone (PubMed:30104550).  The two subunits of the fungal fatty acid synthase oryfasA and oryfasB probably form octenoic acid (Probable).  This fatty acid is most likely activated by the acyl-CoA ligase oryP to give octenyl-CoA before the citrate synthase-like protein oryE catalyzes condensation with oxaloacetate to form tricarboxylic acid (Probable).  The next steps of the pathways are conjectural, but a favorite possible route has been proposed, beginning with decarboxylation and concomitant dehydration by the decarboxylase oryM, followed by tautomerization, which may lead to the production of a diene intermediate (Probable).  Reduction of this diene intermediate could give the known metabolite piliformic acid (Probable).  On the pathway to oryzine B and oryzine A, however, hydroxylation of the diene by the alpha-ketoglutarate-dependent dioxygenase oryG and lactonisation by the lactonohydrolases oryH or oryL could give oryzine B directly (Probable).  Finally, enoyl reduction by the dehydrogenase oryD would then convert oryzine B into oryzine A (Probable).
What are the official names of this protein?
Fatty acid synthase subunit alpha, Oryzines biosynthesis cluster protein oryfasA.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.