PharMolix/UniProtQA huggingface dataset:
Protein: TRMD_GLOC7
Sequence: MRFDIITLFPDFFTSPLQSGLLGKALDKQIAQVNLVNPRDFALDKHHRVDDEPYGGGVGMLLKPEPIFAAVESLEILPRREVVLMTPQGQPLSQPILRELATDFDQLVLICGHYEGVDERVTQYLVTREISLGDFVLTCGEIPALTVLNGVIRLLPGTVGKEESLKLESFEADLLDYPQYTRPALFRDWEVPAVLRSGNHQAIEQWRKQQQIERTKERRPDLWEKWTINNG
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_SYNFM
Sequence: MIGHLEGRLRHKAPDYIVIDVHGVGYIVYVPLSTFYDLPGPGDTVALNIHTHIREDAIQLYGFRTVAEKDMFLRLITVNGVGPRLAVNILSGLTPDDLHRIILQQEGFRLKSIPGVGKKIAERILLELRDKMSVKKGREAEQPAPAAESSYGDAYSALVNLGYRPAEAEKALGKAIKSLGADPPVEKLLKETLRLLA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: MURI_KORVE
Sequence: MSRQRPVIGVFDSGFGGLTVLREIVRLVPNAEYLYFGDTARLPYGTKSADTVARYALGACHFLEGQGAEHLVIACNTATALAMDAIEAKANVPAIGVVEPGASAAAAISKTRSVAVIGTEATISSHAYHHALERLGINAYEKATPLLVPLVEEGWTDHPVTKQVAEIYLQDAFVRREQRSDVLVLGCTHYPLIRPLLRKVVPSDVAIVDSAESTAKALAKKLGIAPPSASAAGATQAAGARAQMAPSAPEPKEGTPDFRFFVTDSVQKFRRLGSGFLGHPVDNVEHVDLGG
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: RTCB_AEDAE
Sequence: MVVREYNEELKYIEKISPNSYLIKKGFQPNMNVEGIFYANSKLERLMFDELRNSCRPGMTGGFLPGVKQIANVAALPGIVGRSVGLPDIHSGYGFAIGNMAAFDMSNPVSIVSPGGVGFDINCGVRLLRTNLFEKDVKPVQEQLAQSLFDHIPVGVGSKGIIPMNAHDLEEALEMGMDWSLREGYVWAEDKEHCEEYGRMLNADPSKVSMRAKKRGLPQLGTLGAGNHYAEIQVVEEIYDKFAASKMGIEELGQICVMIHSGSRGFGHQVATDALVEMEKAMKRDKIETNDRQLACARINSVEGQNYLKAMAAAANFAWVNRSSMTFLTRQAFAKQFNTTPDDLDMHVIYDVSHNVAKMEEHMVDGRPKQLLVHRKGSTRALPPHHPLIPVDYQLTGQPVLIGGSMGTCSFVLTGTEKGMAATFGSTCHGAGRSLSRAKSRRNLDYKDVLRDLEAKGIAIRVASPKLVQEEAPDSYKDVRDVVQTCHDVGISAKAIKLRPIAVIKG
What is the function of this protein?
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.  May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
What are the official names of this protein?
RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
Protein: RL19_RICAH
Sequence: MNIIDHFEQENIAKLTANKQIPDFKAGDTVKVTVKVLDRSIEKDGKEKLTERFQAYEGLVIAKRNRGITSSFLVRKISHGEGVERRFMTYSPIVHSINVVKYGVVRRAKLYYLRNRSGKSARIKERHIHIAKTKTVKA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: COAE_HALH5
Sequence: MMIGLTGGIASGKSSVAKMMEELGLPIVDADQVARDVVEPGMPAYEAIVAHFGTGVVNDDGTLNRKALGSIVFQQEEERRVLNEIVHPAVRRQMQQQKEQLIRSGEKTIVFDIPLLYESNLFYLVEKVLLVYVDEHTQLQRLMNRDQAGKDDAIHRIRSQRPLESKRDRADAIIDNSGTLDATKRQLIDILKRWKVIPEDQ
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
Protein: PQQE_KLEP3
Sequence: MSQNKPAVNPPLWLLAELTYRCPLQCPYCSNPLDFARQEKELTTEQWIEVFRQARAMGSVQLGFSGGEPLTRKDLPELIRAARDLGFYTNLITSGIGLTESKLDAFSEAGLDHIQISFQASDEVLNAALAGNKKAFQQKLAMARAVKARDYPMVLNFVLHRHNIDQLDKIIELCIELEADDVELATCQFYGWAFLNREGLLPTREQIARAEQVVADYRQKMAASGNLTNLLFVTPDYYEERPKGCMGGWGSIFLSVTPEGTALPCHSARQLPVAFPSVLEQSLESIWYDSFGFNRYRGYDWMPEPCRSCDEKEKDFGGCRCQAFMLTGSADNADPVCSKSPHHHKILEARREAACSDIKVSQLQFRNRTRSQLIYKTREL
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: TA2R1_HUMAN
Sequence: MLESHLIIYFLLAVIQFLLGIFTNGIIVVVNGIDLIKHRKMAPLDLLLSCLAVSRIFLQLFIFYVNVIVIFFIEFIMCSANCAILLFINELELWLATWLGVFYCAKVASVRHPLFIWLKMRISKLVPWMILGSLLYVSMICVFHSKYAGFMVPYFLRKFFSQNATIQKEDTLAIQIFSFVAEFSVPLLIFLFAVLLLIFSLGRHTRQMRNTVAGSRVPGRGAPISALLSILSFLILYFSHCMIKVFLSSLKFHIRRFIFLFFILVIGIYPSGHSLILILGNPKLKQNAKKFLLHSKCCQ
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
What are the official names of this protein?
Taste receptor type 2 member 1, T2R1, Taste receptor family B member 7, TRB7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DAR4_ARATH
Sequence: MEPPAARVTPSIKADCSHSVNIICEETVLHSLVSHLSAALRREGISVFVDACGLQETKFFSIKQNQPLTDGARVLVVVISDEVEFYDPWFPKFLKVIQGWQNNGHVVVPVFYGVDSLTRVYGWANSWLEAEKLTSHQSKILSNNVLTDSELVEEIVRDVYGKLYPAERVGIYARLLEIEKLLYKQHRDIRSIGIWGMPGIGKTTLAKAVFNHMSTDYDASCFIENFDEAFHKEGLHRLLKERIGKILKDEFDIESSYIMRPTLHRDKLYDKRILVVLDDVRDSLAAESFLKRLDWFGSGSLIIITSVDKQVFAFCQINQIYTVQGLNVHEALQLFSQSVFGINEPEQNDRKLSMKVIDYVNGNPLALSIYGRELMGKKSEMETAFFELKHCPPLKIQDVLKNAYSALSDNEKNIVLDIAFFFKGETVNYVMQLLEESHYFPRLAIDVLVDKCVLTISENTVQMNNLIQDTCQEIFNGEIETCTRMWEPSRIRYLLEYDELEGSGETKAMPKSGLVAEHIESIFLDTSNVKFDVKHDAFKNMFNLKFLKIYNSCSKYISGLNFPKGLDSLPYELRLLHWENYPLQSLPQDFDFGHLVKLSMPYSQLHKLGTRVKDLVMLKRLILSHSLQLVECDILIYAQNIELIDLQGCTGLQRFPDTSQLQNLRVVNLSGCTEIKCFSGVPPNIEELHLQGTRIREIPIFNATHPPKVKLDRKKLWNLLENFSDVEHIDLECVTNLATVTSNNHVMGKLVCLNMKYCSNLRGLPDMVSLESLKVLYLSGCSELEKIMGFPRNLKKLYVGGTAIRELPQLPNSLEFLNAHGCKHLKSINLDFEQLPRHFIFSNCYRFSSQVIAEFVEKGLVASLARAKQEELIKAPEVIICIPMDTRQRSSFRLQAGRNAMTDLVPWMQKPISGFSMSVVVSFQDDYHNDVGLRIRCVGTWKTWNNQPDRIVERFFQCWAPTEAPKVVADHIFVLYDTKMHPSDSEENHISMWAHEVKFEFHTVSGENNPLGASCKVTECGVEVITAATGDTSVSGIIRESETITIIEKEDTIIDEEDTPLLSRKPEETNRSRSSSELQKLSSTSSKVRSKGNVFWKWLGCFPLQPKNLRSRSRRTTALEEALEEALKEREKLEDTRELQIALIESKKIKKIKQADERDQIKHADEREQRKHSKDHEEEEIESNEKEERRHSKDYVIEELVLKGKGKRKQLDDDKADEKEQIKHSKDHVEEEVNPPLSKCKDCKSAIEDGISINAYGSVWHPQCFCCLRCREPIAMNEISDLRGMYHKPCYKELRHPNCYVCEKKIPRTAEGLKYHEHPFWMETYCPSHDGDGTPKCCSCERLEHCGTQYVMLADFRWLCRECMDSAIMDSDECQPLHFEIREFFEGLHMKIEEEFPVYLVEKNALNKAEKEEKIDKQGDQCLMVVRGICLSEEQIVTSVSQGVRRMLNKQILDTVTESQRVVRKCEVTAILILYGLPRLLTGYILAHEMMHAYLRLNGYRNLNMVLEEGLCQVLGYMWLECQTYVFDTATIASSSSSSRTPLSTTTSKKVDPSDFEKRLVNFCKHQIETDESPFFGDGFRKVNKMMASNNHSLKDTLKEIISISKTPQYSKL
What is the function of this protein?
NB-LRR receptor-like protein that modulates growth, cell death and freezing tolerance in a temperature-dependent manner.  May be involved in defense responses.
What are the official names of this protein?
Protein DA1-related 4, Protein CHILLING SENSITIVE 3.
Protein: UBIG_SINMW
Sequence: MSETARTTIDQSEVDRFSAMAAEWWDPTGKFRPLHKFNPVRLAYIRDRVAEHFGRDPKSRQPLEGLRLLDIGCGGGLLCEPMARMGADVLGADASEKNIGIARTHAAGSGVRVDYRAVTAEALAEAGESFDVVLNMEVVEHVADVDFFMTTCAHMVRPGGMMFVATINRTLKAAALAIFAAENVLRWLPRGTHQYEKLVRPEEIENPLVASGLEIADRTGVFFNPLSNQWNLSKDMDVNYMIVAKRPI
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: THIG_CHLL2
Sequence: MDSLHIGSYTFSSRLILGTGKFSSPGVMLEAVKASGAQLVTVALRRFNREQPGDDLFTPLTSIPGITLMPNTSGASTAAEAVQAARIARELSGSPFIKVEIHPNPQHLMPDPIETYEASKILAKEGFLVMPYIPADPVLAKRLEEAGCVSVMPLGSAIGSGQGLATAEMLKIIIRESTIPVIVDAGLRSPSEAALAMEMGCDAVLVNSAVAVAGNPPVMAEAFAEAVAAGRKAFTAGIMEKSGMAVATSPLTSFLGTEA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_WIGBR
Sequence: MNINATIFGQTIAFFLFVFFCMKYIWPNLISLVEKRRENIAQALNEAKQAKLNLKISKEKAKKRIESAQIKCKNIINEANETKKLLIEEAKKEAIKIKEHIISQGRLDILDEKKRMCEDLKTKISEIIVMSVEKIIESSINKKISDNIIERSISKINKIKG
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: REP_MSVRA
Sequence: MTSSSSNRQFLHRTANTFLTYPQCPEHPEIISQRIWDLVGRWNPLYIICAQEAHEDGNMHLHALIQTDKQVRTTDSRFFDIDGFHPNIQSAMSPNKVRDYILKEPLALFERGTFVPRKKTFLGNSSKGNSEKKPSKDEIMQDIISHATSKPEYLSMVRKSFPYDWATKLQYFEYSANKLFPDIQEEFINPHPTSEPDLLCNESIKDWLQPNIYQQADNGSRKQSLYIVGPTRTGKSTWARSLGRHNYWQNNVDWSSYNEDAIYNIVDDIPFKYCPCWKQLVGCQKEFVVNPKYGKKKKVQMKSKPTIILANSDEDWMKEMTPGQLEYFEANCMIYIMSPGEKWYSPPQLPPTEEV
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific region at the genome origin of replication.  It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.  Acts as an inhibitor of C-sense gene transcription (By similarity).
What are the official names of this protein?
Replication-associated protein, Rep.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RNFG_ALIF1
Sequence: MLTTMKKSSLVLALFAIAATALVTITYALTKDQIAYQQQQQLLSVLNQVVPKEQHDNELYKACVLVKNKDALGSKQAMPIYLASLNGQHSGAAIEAIAPDGYSGNIKIIVGVDSDAMVTGVRVLSHQETPGLGDKIDIRITRWVDGFLGKTVENAEDKNWAVQKDGGQFDQFTGATITPRAVVKAVKRAVWFYKTHQEELQTLPLNCETK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit G, Rnf electron transport complex subunit G.
What is the protein family that this protein belongs to?
Belongs to the RnfG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IHFB_ECOSM
Sequence: MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: KIN17_HUMAN
Sequence: MGKSDFLTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEEQVRRGLEGKEQEVPTFTELSRENDEEKVTFNLSKGACSSSGATSSKSSTLGPSALKTIGSSASVKRKESSQSSTQSKEKKKKKSALDEIMEIEEEKKRTARTDYWLQPEIIVKIITKKLGEKYHKKKAIVKEVIDKYTAVVKMIDSGDKLKLDQTHLETVIPAPGKRILVLNGGYRGNEGTLESINEKTFSATIVIETGPLKGRRVEGIQYEDISKLA
What is the function of this protein?
Involved in DNA replication and the cellular response to DNA damage.  May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes.  May play a role in illegitimate recombination and regulation of gene expression.  May participate in mRNA processing.  Binds, in vitro, to double-stranded DNA.  Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity).  Binds via its C-terminal domain to RNA in vitro.
What are the official names of this protein?
DNA/RNA-binding protein KIN17, Binding to curved DNA, KIN, antigenic determinant of recA protein homolog.
What is the protein family that this protein belongs to?
Belongs to the KIN17 family.
Protein: TSAD_ORITB
Sequence: MNVIGIESSCDDTAIAIVNSNREIIANVVISQYTEHLPYSGVVPEIAARAHLKNLQYAMKETLNQAKINFTDIDVIAATSGPGLIGGIIVGSVFGQAIACALGKDFIAVNHLEGHILAVRLNENISFPYLVLLVSGGHCQFIAVLGVGKYKILGQTIDDAVGEAFDKTARLLKLGYPGGPIIEKLASKGDPHKYSLPLSMTKKSGCDLSFSGLKTAVKQLIFSIESLSEKVICDICASFQYTVVQILLCRSINAIKLFESYCSNNFKINRKNYFVISGGVAANQYLRQEIFNLANTYGYCGVAPPSNLCTDNAAMIAWAGIERLNANLFSSNFVPRAKWSVEEL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_STRA3
Sequence: MSERKLFTSESVSEGHPDKIADQISDAILDAILEQDPDAHVAAETAVYTGSVHVFGEISTTAYVDINRVVRNTIAEIGYDKAEYGFSAESVGVHPSLVEQSPDIAQGVNEALEVRGSLEQDPLDLIGAGDQGLMFGFAVDETPELMPLPISLAHQLVKKLTDLRKSGELTYLRPDAKSQVTVEYDENNQPIRVDAVVISTQHDPNVTNDQLHKDVIEKVINEVIPSHYLDDQTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAADLAKKVEVQLAYAIGVAQPVSVRVDTFGTGVIAEADLEAAVRQIFDLRPAGIINMLDLKRPIYRQTAAYGHMGRTDIDLPWERVDKVQALKDFIASK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_PROMS
Sequence: MENYSSLLIGGKQFSSRLMVGTGKYKSTQDMVASLSNSETEIITVAVRRIKNDQTGENLLEKINWEKYWMLPNTAGCVNSDEAVRIAILGRELAKLSGQEENNFVKLEVIPDKKYLLPDPIETLKAAEILIKKGFAVLPYINADPILAKRLEEIGCATVMPLGSPIGSGQGLLNLSNIRIIIENSKVPVIIDAGIGVPSEASQAMEIGADGVLINSAIAQAANPPLMAQAINYSVKAGRQAFLAGRIKKQDFAVASSPEKNISI
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCMC_ANSAN
Sequence: MRGLRRGLSRLGPRLGPWAVPRSLRRVLRAAGPWRGQSSAGSVSERGGASMEEVLSRSVPLLPPYETKEKAPPPAERRSAEFVRYYRGLEAGSRRAELLGCLARDFGADHGRVAEFSAKVLQAREQEREQGALLQAEDRVRYYLTPRYRALFQHLGRLEGGLRFLVELRGDLVEGLAAKAVDGPHVKEMSGVLKNMLSEWFSTGFLNLERVTWQSPCEVLQKISDSEAVHPVRNWVDLKRRVGPYRRCYFFSHCAIPGEPLIILHVALTSDISSSIQSIVKDVESLETEDAEKITTAIFYSISLAQQGLQGVELGNHLIKRVVKELQKDLPQIEAFSSLSPIPGFTKWLVGLLSSQTKELGRNELFTESERQEISEITEDSTTETLKKLLTNSEWVKSEKLVKALHSPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAELWRINWMGDTSPRGIAASCGMMVNYRYFLEDTASNSAAYLGTKHIKASEQVLSFVSQFQQNSKL
What is the function of this protein?
Catalyzes the conversion of malonyl-CoA to acetyl-CoA.  In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced.
What are the official names of this protein?
Malonyl-CoA decarboxylase, mitochondrial, MCD.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Peroxisome. Note=Mitochondrial in liver. Cytoplasmic in uropygial gland.
Protein: ARAB2_STAS1
Sequence: MTYSIGIDFGTGSGRVFLVNTENGEIIGQYVQTYAHGTIEGELNGHKLPQSYALQNANDYMEVIETGIPEILAKTNIDAKDIVGIGIDFTSSTVIFVDDQMEPMHNNPKFYNNPHAYVKLWKHHGAQAEADLLFNTAIEEKNRWLGYYGFNVSSEWMIPKIMEVNDKAPEVMTETADIMEAGDWIVNRLTGENVRSNCGLGFKSFWESSTGFHYDLFDKVDDNLSDIVRTKVEAPIVSIGESVGTVSAEMAHKLGLSPETVVSPFIIDAHSSLLGIGAEKDKEMTMVMGTSTCHLMLNKEQHKVPGISGSVKGAIIPDLYAYEAGQTAVGDLFEYVANQSPYEYVKTAEDRGISIFELLNEKASQRYPGESGLIALDWHNGNRSVLSDSNLKGSLFGLSLQTKHEDIYRAYMEATAFGTKMIMQQYQGWQMEVERVFACGGIPKKNHLLMEIYANVLNKKITVIDSEYAPAIGAAILGAICGGAHPNFSSAIQAMKEPVLYQVEPDHAQVLIYKKLFNAYKELHDLLGYKKARIMRNVSALM
What are the official names of this protein?
Ribulokinase 2.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: CLPP1_RHIME
Sequence: MREAMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVNDAVSALVCAQLLFLEAESPKKPIQLYINSPGGVVTSGFAMYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEAGERTALPNASILVHQPSGGFQGQASDMLIHAEEIRRTKHRMTRLYAEHCGRTYEEFERAMDRDRFMTAEEALEWGLIDRIITEREIGAERDA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUND1_CHICK
Sequence: MAARRPRTAPEHESDDDSYEVLDLTEYARRHHWWNRLFGRNSGPIVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQVDWKRVEKDVNKAKKQLKKRANKAAPEINTLIEESTEFIKQNIVVSSGFVGGFLLGLAS
What is the function of this protein?
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
What are the official names of this protein?
FUN14 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the FUN14 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: CRGB_MOUSE
Sequence: MGKITFFEDRSFQGRCYECSSDCPNLQTYFSRCNSVRVDSGCWMLYERPNYQGHQYFLRRGEYPDYQQWMGFSDSIRSCCLIPQHSGTYRMRIYEKDDFRGQMSEITDDCLSLQDRFHFSEIHSLNVMEGCWVLYEMPSYRGRQYLLRPGEYRRYLDWGAANAKVGSFRRVMDFY
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin B, Gamma-B-crystallin, Gamma-crystallin 3.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: NIKE_SHIFL
Sequence: MTLLNVCGLSHHYAHGGFSGKHQHQAVLNNVSLTLKSGETVALLGRSGCGKSTLARLLVGLESPSQGNISWHGESLAKLNRAQRKAFRRDIQMVFQDSISAVNPRKTVREILREPMRHLLSLKKSEQLARASEMLKAVDLDDSVLDKRPPQLSGGQLQLVCLARALAVEPKLLILDEAVSNLDLVLQAGVIRLLKKLQQQFGTACLFITHDLRLVERFCQRVMVMDNGQIAETQAVGDKLTFSSDAGRVLQNAVLPAFPVRRRTSEKV
What is the function of this protein?
Part of the ABC transporter complex NikABCDE involved in nickel import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Nickel import ATP-binding protein NikE.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HBG1_HYLLA
Sequence: MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGGAIKNLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVTVLAIHFGKEFTPEVQASWQKMVAGVASALSSRYH
What is the function of this protein?
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
What are the official names of this protein?
Hemoglobin subunit gamma-1, Gamma-1-globin, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RL10_STRZJ
Sequence: MSEAIIAKKAELVDVVAEKMKAAASIVVVDARGLTVEQDTVLRRELRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNDFSKNAEALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVAESKEDAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: NADE_COPPD
Sequence: MNTAMEETQRIEQFLRKALVSERKHGYLIGVSGGLDSAVVLKLLVQAVGKENVLGLILPDRDTEKKSTTLARSLLEQEKVPYKVISMTPLLRHLGVYKDMPLFLLPTRGLKESIVRRFYNDYTKKLNKPVFFAQWEEPPTQLPYFYEGIAYYRIKHRVRMATLYYYAEKNDYLLVGCTNLSERLIGFYVKYGDDVCDVAPIAHLYKTEVRQLSEYLSVPEDIRNRPPSPDLIPGITDEYSLGINYETLDQILAGLEEGKTAEDLKQLFPADIVELVINQVKFTQKLEGKPYMLKRA
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.