PharMolix/UniProtQA huggingface dataset:
Protein: RF3_LACAC
Sequence: MDKELAEKVEKRRTFAIISHPDAGKTTITEQMLLFGGVIRKAGTVKARKTGNFATSDWMEIEKKRGISVTSSVMQFEYKGKRINILDTPGHQDFSEDTYRTLMAVDSAVMVIDSAKGIEPQTKKLFKVVKQRGIPIFTFMNKLDRDGRPPLDLIAELEDLLGIEGVAMNWPIGSGQTLKGLYDIANNRVELYRKDGEDRFLPLNDDGTLPDSEALSQDPQFKDTLDEIELIKEAGNKFNREKIAMGDQTPVFFGSALTNFGVETFLNSFVDLAPAPESHTVNEDEELSPEDPEFSGFVFKIQANMNPNHRDRIAFVRIGSGEFKKGLDVTLARTGKPIRLNNATEFMSSERVQVSDAVAGDIVGLYDTGNFQIGDSIYSGKRKIVYPALPEFTPELFMRVTAKNVMKQKSFHKGMNQLVQEGAIQLYRNYQTDEYILGAVGQLQFEVFQFRMKNEYNSEVEMNSIGHRVARWIDPEQLDPQMSNSRNLLVKDRYGNPLFLFENEFAERFFRDKYPDIKLTEKL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_BORPE
Sequence: MSDIQLNTLKPAEGSKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFTPLGQHLYAEVRLSELQLMEAEEIDVQALKAAGVVGQSVRYAKVIKSGELSRKVVLRGITATAGARAAIEAAGGSLA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GLMU_RHOPT
Sequence: MTARNSLTIVLAAGEGTRMRSSLPKVLNPVAGRSLLAHVLSAAPHGERDRLAVVIGPDHRAVGDEAKRVRSDAAIHIQAQRLGTAHAVLAAREAIAEGADDLLIAFGDTPLISAETFARLREPLHDGSSLVVLGFRAADPTGYGRLVVQDGKLTAIREQADASADELKITLCNAGVMAIDGKIALDVLDKIGNANAKGEYYLTDAVGIVRDLGLIASVIETSEDEVRGINTKAQLAEAETVMQTRLRLAAMAAGVTLIAPETVYLAADTTFGKDVVIEPFVVIGPGVSIADGAVIHSFSHLAEAKIGSKAQVGPYARLRPGTSLGDGAKIGNFVETKAAQIDAGAKVNHLTYIGDAHIGASANIGAGTITCNYDGFDKHKTEIGAGAFIGSNSSLVAPVKIGTGAYVGSGSVITKDVPDDALAVERNVQTAKDGWAKRFRDAKSRHRKPKAH
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_DROME
Sequence: MKLNVSYPATGCQKLFEVVDEHKLRVFYEKRMGQVVEADILGDEWKGYQLRIAGGNDKQGFPMKQGVLTHGRVRLLLKKGHSCYRPRRTGERKRKSVRGCIVDANMSVLALVVLKKGEKDIPGLTDTTIPRRLGPKRASKIRKLYNLSKEDDVRRFVVRRPLPAKDNKKATSKAPKIQRLITPVVLQRKHRRIALKKKRQIASKEASADYAKLLVQRKKESKAKREEAKRRRSASIRESKSSVSSDKK
What is the function of this protein?
Component of the 40S small ribosomal subunit.  Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: PSMD7_MOUSE
Sequence: MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVASGKLPINHQIIYQLQDVFNLLPDASLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKERKDDKEKEKSDAAKKEEKKEKK
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 7, 26S proteasome regulatory subunit RPN8, 26S proteasome regulatory subunit S12, Mov34 protein, Proteasome subunit p40.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family.
Protein: FABZ_AERS4
Sequence: MTTEKKSLGIQEIMDLLPHRYPFLMVDRVDDYEISDERKTLRAIKNVSFNEPIFQGHFPAKPVFPGVLILEAMAQATGILAFTMVGKPSPNELYYFASIDNARFKRPVGPGDQLVLDVEFLKERRGIAKFTGVATVNGEVVCTAELMCAKREV
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_LACLC
Sequence: MPELPEVETVRRELEKRIVGQKIISIEATYPRMVLTGFEQLKKELTGKTIQGISRRGKYLIFEIGDDFRLISHLRMEGKYRLATLDAPREKHDHLTMKFADGQLIYADVRKFGTWELISTDQVLPYFLKKKIGPEPTYDEDFDEKLFREKLRKSTKKIKPYLLEQTLVAGLGNIYVDEVLWLAKIHPEKETNQLIESSIHLLHDSIIEILQKAIKLGGSSIRTYSALGSTGKMQNELQVYGKTGEKCSRCGAEIQKIKVAGRGTHFCPVCQQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: NACC2_RAT
Sequence: MSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGTVPPACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAMIEDASSEPQSPCNQLQPATAAYATSPSVPIPLLTRVKHEAMEMPPATGPGLASKRPLDTGPRDGVAVATGAAGTPGTAPLKLPRVSYYGVPSLATLIPSIQQVPYPQGERTSPGASSLPTTDSSTSYHNEDEDDDEAYDTMVEEQYGQMYIKATGNYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELVAGSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSFKESEMNVIAADMCTNARRVRKRWLPKIKSMLPEGVEMYRSVMGASAASLPLDPEFPSAASQVFEQRIYAERRNDAATIVALRTDAVNVDLSTSANPAFEANEEVDGAGSVIQEVAAPEQLPADGQSSPQAFEQGNTSSSRPQTPVATATRRPEGTYAGTL
What is the function of this protein?
Functions as a transcriptional repressor through its association with the NuRD complex.  Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity).
What are the official names of this protein?
Nucleus accumbens-associated protein 2, NAC-2, BTB/POZ domain-containing protein 14A.
What are the subcellular locations of this protein?
Nucleus. Note=Predominantly associated with chromatin.
Protein: MURG_STAA1
Sequence: MTKIAFTGGGTVGHVSVNLSLIPTALSQGYEALYIGSKNGIEREMIESQLPEIKYYPISSGKLRRYISLENAKDVFKVLKGILDARKVLKKEKPDLLFSKGGFVSVPVVIAAKSLNIPTIIHESDLTPGLANKIALKFAKKIYTTFEETLNYLPKEKADFIGATIREDLKNGNAHNGYQLTGFNENKKVLLVMGGSLGSKKLNSIIRENLDALLQQYQVIHLTGKGLKDAQVKKSGYIQYEFVKEDLTDLLAITDTVISRAGSNAIYEFLTLRIPMLLVPLGLDQSRGDQIDNANHFADKGYAKTIDEEQLTAQILLQELNEMEQERTRIINNMKSYEQSYTKEALFDKMIKDALN
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PCDB8_PANTR
Sequence: MEASGKLICRQRQVLFSFLLLGLSLAGAAEPRSYSVVEETEGSSFVTNLAKDLGLEQREFSRRGVRVVSRGNKLHLQLNQETGDLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTAFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVVDVNDNAPEFEQPFYRVQISEDSPISFLVVKVSATDVDTGVNGEISYSLFQASDEISKTFKVDFLTGEIRLKKQLDFEKFQSYEVNIEARDAGGFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCSIQEDLPFLLKSSVGNFYTLLTETPLDRESRAEYNVTITVTDLGTPGLTTHLNMTVLVSDVNDNAPAFTQASYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLPLASLVSINTDNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNSSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPCSATATLHVLLVDGFSQPYLPLPEAAPAQGQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVRGTGSLSQNYQYEVCLAGGSGTNEFQFLKPVLPNIQGHSFGPEMEQNSNFRNGFGFSLQLK
What is the function of this protein?
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination.  Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin beta-8, PCDH-beta-8.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ATP6_SQUAC
Sequence: MNLSFFDQFLSPSLLGIPLIAMAIMIPWLIFPTPTNRWLNNRLMTVQSWFINRFTYQLMQPMNFGGHKWATILTALMLFLITINLLGLLPYTFTPTTQLSLNMAFAIPLWLTTVLIGMLNQPTVALGHLLPEGTPTLLIPILIIIETISLFIRPLALGVRLTANLTAGHLLMQLIATAAFVLITIMPTVALLTSLILFLLTILEVAVAMIQAYVFVLLLSLYLQENV
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane (By similarity).
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MAND_ENT38
Sequence: MKIVGAEVFVTCPGRNFVTLKITTDDGLVGLGDATLNGRELSVASYLKDHLCPQLIGRDAHRIEDIWQFFYKGAYWRRGPVTMSAISAVDMALWDIKAKAAGMPLYQLLGGASREGVMVYCHTTGHTIDDVLEDYARHKEMGFKAIRVQCGVPGMKTTYGMSKGKGLAYEPATKGDWPEEQLWSTEKYLDFTPKLFDAVRSKFGYDEHLLHDMHHRLTPIEAARFGKSIEEFRLFWMEDPTPAENQECFRLIRQHTVTPIAVGEVFNSIWDCKQLIEEQLIDYIRTTMTHAGGITGMRRIADFASLYQVRTGSHGPSDLSPICHAAALHFDLWVPNFGVQEYMGYSEQMLEVFPHSWTFDNGYMHPGEKPGLGIEFDEKLAAKYPYDPAYLPVARLEDGTLWNW
What is the function of this protein?
Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo.  Has no detectable activity with a panel of 70 other acid sugars (in vitro).
What are the official names of this protein?
D-galactonate dehydratase family member Ent638_1932, D-mannonate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: DNLJ_CLOP1
Sequence: MDKKKLIEELVEELNKYAYEYYVLGNSSVTDKDYDKKYYELVDLEKETGYKLPYSPTQRVGDVILPEFKKYTHKARLWSLDKAQTLEEIREWHNRNVKFLEEYNRTSDEELPPLKYILTKKFDGLTINLSYDENGVLVTGATRGTGAIGEDVTAQVKTIKSIPLKIDCHDFLEIHGEAIMTTEAFEKYNSEADTPLKNLRNGAAGALRNLNVAETAKRNLSAFFYDVGYKEGAPFKTYMEMLNFIKTKGFPMDDYIRECTTLDEIQKEIDYIRDIRFDLNYDIDGLVIAIDDIRTRELLGYTVKFPKWAIAYKFEAQEATTKLLDVEWNVGRSGRVSPTAILEPVELAGVTVKRATLNNMDDIARKGVRLGAEVFVRRSNDVIPEIMGVVPESLEGTKEIEEPKVCPACGAHLVHEGVHIYCENTLGCKPQMVKTIVHFAGREAMNIAGFSEKTAEQLFEKLDIRDISDLYKLEYEKLLDLDKFGPKKAQNLLDAIEKSKDCTLEAFLYSLGIPNVGVKTAKDLVKRFESLENLEKATFEELVSVQDVGDIVARSIIEFFKEERTLKVINELLSLGVNPHYEKKEVLESPFMGKTVVVTGTLENYSRTSIKEKLESLGAKVSGSVSKKTDFVIAGEAAGSKYDKAKSLGVTILSEEEFENMI
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL24_BORA1
Sequence: MNKILKGDEVIVLTGRDKKRRGVVLARVDADHVLVEGVNVVKKHQKANPMANNPGGIVEKTLPIHISNVALFNPATGKADRVGFKEEDGRKVRVFRSNGAAVGAKA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PSRP_YERPP
Sequence: MERCVFYISDGTAITAEVLGHAVLSQFPINVTTFTLPFVENAARAQSVCKQINEIYQDTGVRPLVFYSIISLEVREIIQRSEGFCQDIVQALVAPLQGELGVPPQPVLNRTHGLTESNLDKYDARIAAIDYALAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLQLPAALKPFQHKLFGLTINPERLAAIREERRENSRYASLRQCRMEVGEVEALFRKNQIRYLNSTNYSVEEISTKILDILGMSRRMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: ALG13_RAT
Sequence: MKRAFVTVGTTSFDDLVARVVANDTVQILKSLGYNHLVLQIGRGTVVPEPFSTEPFTLDVYRYKESLKEDLQQADLVISHAGAGSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEGHLFYCTCSMLPGLLQSMDLSTLKCYPPGQPEKFSAFLDKVVGLQK
What is the function of this protein?
May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway.
What are the official names of this protein?
UDP-N-acetylglucosamine transferase subunit ALG13 homolog, Glycosyltransferase 28 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Note=Could be recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14.
Protein: DOIAD_STRFR
Sequence: MKALVFEAPERAVLTHRDIPAPAPGEALVRVAYNSVCGSDLSFYKGVWHGFTYPVVPGHEWSGSVVDVNGPRGADLVGRNVVGDLTCSCGTCAHCAAGTPTLCEDLGELGFTRDGACAEYMTVPVANLRPLPDTLPLRTACQVEPLAVALNAVDRLGVTPGEKVAVMGAGGIGLLLVQAVRLRGGTVTAVAEPVPERRAAALALGVPAAVGGDPGALVELTRSDPAAVPDVVLEASGYPTAVQEAVEAVRPGGRVGLVGYRIEEAAVMAPHHIVLKVLTVRASMGPGTRFEEAVDVLASGAVDVDALLSHEFALDDYAKALDVALRRADGNTRSYFNLRA
What is the function of this protein?
Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD(+) or NADP(+), forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).
What are the official names of this protein?
2-deoxy-scyllo-inosamine dehydrogenase, DOIA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. DOIA dehydrogenase subfamily.
Protein: MTD_METLZ
Sequence: MVVKVGVAKLGNIAAGVMAELLLDERADREDMMTFMATSGTKLQKEDVDRVVSNLKAWQPDFAIVVSPNGVLEGPVGAREDLKAAGIPTIVITDDVTTKKEGWEALKASGFGYIIVKADAMIGARREFLDPVEMADYNGNLVKVLALTGAFRKLQLELDKVIDQVKAGKKGAELELPKLVLNSDNSTKGEFTNPYALAKARAAYEIAQAVAGVNVKGCFMTKEWTDYVPIVASAHEMMRAAANLCDQARELEKGCDGVIRKPHKKTGEIVSKVALISKPE
What is the function of this protein?
Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
What are the official names of this protein?
F420-dependent methylenetetrahydromethanopterin dehydrogenase, MTD, Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MTD family.
Protein: ATPA_ALKEH
Sequence: MQLNPSEISELIKRRIENFEAVAEARNQGTIVSVGDGICRIHGLADAMQGEMLEFPNDTFGMALNLERDSVGAVILGDYEHLSEGDTVKCTGRILEVPVGESLLGRVVDALGNPVDAKGEIKAEGSSPVEKVAPGVISRQSVDQPVQTGLKAVDAMVPIGRGQRELIIGDRQTGKTAVAIDAIINQKNSGIKCIYVAIGQKASSIASVVEKLKEHDALDHTIVVAASASESAAMQYLAAYAGCAMGEYFRDRGEDALIVYDDLTKQAWAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARINAEEVEKLTNGEVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIYLETDLFNSGIRPAINAGLSVSRVGGSAQTKLIKKLGGGIRLALAQYRELAAFAQFASDLDEATRKQLERGQRVMELMKQPQYTPMTVAEMGISLYAADAGYLDDVEVNKVVDFQAALLDYLRSEEKGLLDELNSTPDYNDEVVGKMKKAVEAFKSSRTW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: K2C1B_HUMAN
Sequence: MSHQFSSQSAFSSMSRRVYSTSSSAGSGGGSPAVGSVCYARGRCGGGGYGIHGRGFGSRSLYNLGGSRSISINLMGRSTSGFCQGGGVGGFGGGRGFGVGSTGAGGFGGGGFGGAGFGTSNFGLGGFGPYCPPGGIQEVTINQSLLEPLHLEVDPEIQRIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQNSQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGRSGGGYGSGCGGGGGSYGGSGRSGRGSSRVQIIQTSTNTSHRRILE
What are the official names of this protein?
Keratin, type II cytoskeletal 1b, Cytokeratin-1B, CK-1B, Keratin-77, K77, Type-II keratin Kb39.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: FDB33_GIBM7
Sequence: MTIILHRSDFFEAILNHEGSSVAVVENESGASFCYSSLLNSVARAKEQLLAKTGKCDTSVSGERIAFLVESGYEYVVTLLTILACNAIAVPLAPSFPAPELRYIINNSEALALISSAKYVSKAEEVLAEGLDNTPLFCQLDGTRNISAIEEEVKLRDFSDEPRGGMMLFTSGTTARPKGVVLSQTNLTAQAKCLLEAWKYAPSDRLLHVLPLHHIHGTVNALLTPLLAGSSIEFMYPFNVNSVWTRLAAPFLENEQINGHSEKTNGAQKDETRVPISFFTAVPTIWSRMLKAHDSLSHDMQAAGKIAVSPNNLRLNISGSAALPKPIRDGWIQLTGGNVLLERYGMTEVGMALSCGLENTDRVDGSVGWPLPSVEARLMETDDETEIQRIIEHGAEIDAHSGKERIGEIQLRGPTVFTGYWRNPEATAKEFTTDGWFKTGDIAIRRQVPESGLGKSGSWAKGPAYFIQGRRSADIIKTGGEKVSALEVEREILALPEVDECAVVGLPSEAWGQKVAAVIVLSSKVGGSMSLQSLRSALKTRITAYKIPQDLEIVEFLPRNAMGKINKKELVKSVFGEVEKIRRRSIDLQTKRPVLNGQRG
What is the function of this protein?
CoA ligase; part of the Fusarium detoxification of benzoxazolinone cluster 2 (FDB2) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:19302487, PubMed:26808652).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).  The first step in the detoxification of benzoxazolinones involves the hydrolysis of the cyclic ester bond of benzoxazolinones by the FDB1 cluster gamma-lactamase MBL1 to aminophenols (PubMed:26808652, PubMed:12788712).  MBL1 is able to convert BOA into 2-aminophenol (2-AP), as well as MBOA into 5-methoxy-2-aminophenol (2-AMP) (PubMed:26808652, PubMed:12788712).  The FDB2 cluster N-malonyltransferase FDB2/NAT1 then metabolizes aminophenols via N-malonylation to non-toxic malonamic acids (PubMed:19302487, PubMed:12788712).  FDB2/NAT1 converts 2-AP into N-(2-hydroxyphenyl) malonamic acid (HPMA) and 2-AMP into N-(2-hydroxy-4-methoxyphenyl) malonamic acid (HMPMA) (PubMed:19302487, PubMed:12788712).  The duplicated dienlactone hydrolases DLH1 and DLH2 may provide redundant function for hydrolyzing the lactone moiety in the BOA molecule (Probable).  The roles of the amidases an other enzymes encoded by the 2 FDB clusters have not been identified so far (Probable).
What are the official names of this protein?
CoA ligase FVEG_12633, Fusarium detoxification of benzoxazolinone cluster 2 protein FVEG_12633, FDB2 cluster protein FVEG_12633.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: LEU1_BUCAI
Sequence: MKSKVVIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGDFKSVQTISKNIKNSRICSLARCIEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKKNFNEIIDMAVFSVKKALRYTDDIEFSCEDATRTTMDNLCRIVETLIKSGVKTINIPDTVGYTVPNELSCIIKNLFERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMGYNNSDYNIDELYTAFLKLADKKGQVFDYDLEALAFINKQQDEWEYFSLKFFSVQSISNSLSTASVKLLCGKKTYTESSTTSNGPVDAIYQALNRIACFPIILQKFQLVAKGKGKDALGQVDILVEHKKRKFHGVGLATDIIEASAQAMINVLNNIWKAKQVNKKLKILKDFKKK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.