PharMolix/UniProtQA huggingface dataset:
Protein: RL23_THETH
Sequence: MKTAYDVILAPVLSEKAYAGFAEGKYTFWVHPKATKTEIKNAVETAFKVKVVKVNTLHVRGKKKRLGRYLGKRPDRKKAIVQVAPGQKIEALEGLI
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23, L*23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RS5_SULIN
Sequence: MAEEVPSINIEEWKPRTSIGNLVKNGKISSIKELFDRNLPITEPEIVDVLLPKLKYEVVDIKVVQKQTDAGEISRYKVLVIMGNMDGYVSIGTGKAKQLRVAIQKAIRDAKMNILPVRRGCGSWQCTCGEPHSLPFKVVGKAGSVEVNLLPAPKGTGLVVGSVLKTLLTYAGIRDAWSTTKGETRTTENFVRAGYSALYNTYNFVTLQDWARKR
What is the function of this protein?
With S4 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: MDH_FRAT1
Sequence: MARKKITLVGAGNIGGTLAHLALIKQLGDVVLFDIAQGMPNGKALDLLQTCPIEGVDFKVRGTNDYKDLENSDVVIVTAGVPRKPGMSRDDLLGINIKVMQTVGEGIKHNCPNAFVICITNPLDIMVNMLQKFSGVPDNKIVGMAGVLDSARFRTFLADELNVSVQQVQAYVMGGHGDTMVPLTKMSNVAGVSLEQLVKEGKLKQERLDAIVSRTRSGGGEIVALLKTGSAYYAPAAAGIQMAESFLKDKKMILPCAAKVKAGMYGLDEDLFVGVPTEISANGVRPIEVEISDKEREQLQVSINAIKDLNKAAAEILAK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: FTHS_SHEON
Sequence: MLTDMEISRRAHLKDIAQLGAEFGLLPEEMQLFGNTKAKVDLQVQQRLAGQPKGKLIIVTAVTPTPHGEGKTVTTIGLTQSLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSSAHNLGAAAIASRLYHEMRLGKAEFERQSGLSYLDIDPKGIRWHRVVDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLTDMRVRIGKLVLALNRQGEAVSADELGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDIALKLADFVVTEGGFGSDMGFEKFCNIKARQSGLIPSAAVLVTTLKALKANSGLASDTDINAPDQARLEAGFANLNWHINNVVQYGLPVVVAINRFASDTDAELNWLMEAVRGTAAFGCELSEAFSQGEDGAMALAQTVIRACEQPSEFRLLYPDNMELEAKLSTLAELGYGAAGINLSAVAKQQLQELSALGYAHLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALVGNVMTMPGLGLTPGYLKIDIDVDGEIIGLG
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: TRMB_BRUMA
Sequence: MVSTENKIGLFKNKDDDIDGEEMRELPQKKFYRQRAHANPISDHEFDYPVFPEQMDWKKYFGDFSEGRQVEFADVGCGYGGLLIKLSTLYPEALMVGLEIRVKVSDYVQDKIHALRLREPGNYRNVACLRTNAMKYLPNYFRRHQLTKMFFLYPDPHFKKAKHKWRIITPTLLAEYAYVLKPGGLVYTITDVEELHIWMVRHLSAHPLFERLTDLEMKMDPVVEMLYDSTEEGQKVARNEGSKWSAVFRRLPNPVLSS
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOC2_GOSHI
Sequence: MAERANLVFHNKVIDGTAIKRLISRLIDHFGMAYTSHILDQVKALGFQQATATSISLGIDDLLTIPSKGWLVQDAEQQSLILEKHHHFGNVHAVEKLRQSIEIWYATSEYLRQEMNPNFRMTDPFNPVHIMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTTRGISVSPQKRTLPERIFIQTLIGRVLADDIYMGPRCIAIRNQDIGLGLVDRFRAFRTQPISIRTPFTCRSTSWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPFNGKIKFNEDLVHPTRTRHGHPAFLCYRDLYVIIESEDIIHKVAIPPKSFLLVQNDQYVESEQVIAEIRAGTYTLNLKERVRKHIYSDSEGEMHWSTDVYHSPEFTYSNVHLLPKTSHLWILSGGSYKFSVVPFSLHKDQDQISIHYLSAERRYISRFSVNNDQVRHNLFSSDFSDKKEERIYDYSELNRIIGTGHCDFIYSAILHENADLLAKRRRNRFIIPFQLIQDQEKELMLHSHSGISMEIPINGIFRRKSILAFFDDPRYRRKSSGITKYGTLGAHSIVKREDVIEYRGVKKVKPKYQMKVDRFFFIPEEVHILSESSSIMVRNNSIIGVDTPITLNTRSQVGGLVRVERKKKRIELKIFSGNIYFPGERDKISRHSGILIPPGTGKTNSKESKKLKNWIYVQRITPTKKKYFVLVRPVTPYEIPDGLNLATLFPQDPFQEKDNMQLRAVNYILYGNGKPTRRISDTSIQLVRTCLVLSWDQDNKSSFAEEVCASFVEVRTNGLIRDFLRIDLVKSHIFYIRKRNDPSGSELISDNRSDRTNKNPFYSIYSNARIQQSFSQNHGTIHTLLNRNKESQSLIILSASNCFRMGPFNDVKYHNVIKQSIKKDPLIPIKNLLGPLGTAPKIANFYSSFYPLITHNQTSVAKYFELDNLKQAFQVLNYYLIAENGRIYNFDPCRNIFLNAVNLNWYFPHHHYHHNYCEETSTIISLGQFICENVCIAKSGPRLKSGQVFIVQADSIVIRSAKPYLATPGATVHGHYGETLYEGDTLVTFIYEKSRSGDITQGLPKVEQVLEVRSIDSISMNLEKRIEGWNECITRILGIPWGFVIGAELTIVQSRLSLVNKIQKVYRSQGVQIHNRHIEIIVRQITSKVLVSEDGMSNVFLPGELIGLLRAERTGRALEEAICYRAVLLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGMIPAGTGFKGLVHRSRQHNNILLETKKKNFFGGEMRDIFFHHRELFDSCISNNLHDTSGRSFIGIEFNDS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LYPGN_MYCBO
Sequence: MGSIAGFSSAVLSKLGIPVPYAPRLLAGGWVVAGWAGLAYGVYLTVIALRLPPGSELTGHAMLQPAFKASMAVLLAAAAVAHPIGRERRWLVPALLLSATGDWLLAIPWWTWAFVFGLGAFLLAHLCFIGALLPLARQAAPSRGRVAAVVAMCVASAGLLVWFWPHLGKDNLTIPVTVYIVALSAMVCTALLARLPTIWTAVGAVCFAASDSMIGIGRFILGNEALAVPIWWSYAAAEILITAGFFFGREVPDNAAAPTDS
What is the function of this protein?
Specifically hydrolyzes the vinyl ether bond of lysoplasmenylcholine (pLPC) and lysoplasmenylethanolamine (pLPE) to release a fatty aldehyde and glycerophospho-choline or glycerophospho-ethanolamine.
What are the official names of this protein?
Lysoplasmalogenase.
What is the protein family that this protein belongs to?
Belongs to the TMEM86 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IL6RA_MOUSE
Sequence: MLTVGCTLLVALLAAPAVALVLGSCRALEVANGTVTSLPGATVTLICPGKEAAGNVTIHWVYSGSQNREWTTTGNTLVLRDVQLSDTGDYLCSLNDHLVGTVPLLVDVPPEEPKLSCFRKNPLVNAICEWRPSSTPSPTTKAVLFAKKINTTNGKSDFQVPCQYSQQLKSFSCQVEILEGDKVYHIVSLCVANSVGSKSSHNEAFHSLKMVQPDPPANLVVSAIPGRPRWLKVSWQHPETWDPSYYLLQFQLRYRPVWSKEFTVLLLPVAQYQCVIHDALRGVKHVVQVRGKEELDLGQWSEWSPEVTGTPWIAEPRTTPAGILWNPTQVSVEDSANHEDQYESSTEATSVLAPVQESSSMSLPTFLVAGGSLAFGLLLCVFIILRLKQKWKSEAEKESKTTSPPPPPYSLGPLKPTFLLVPLLTPHSSGSDNTVNHSCLGVRDAQSPYDNSNRDYLFPR
What is the function of this protein?
Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:11113088).  The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'.  sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (By similarity).  In complex with IL6, is required for induction of VEGF production (By similarity).  Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088).  'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851).
What are the official names of this protein?
Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 3 subfamily.
What are the subcellular locations of this protein?
[Interleukin-6 receptor subunit alpha]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Soluble interleukin-6 receptor subunit alpha]: Secreted.
Protein: HUNK_PANTR
Sequence: MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHIEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCSPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
What are the official names of this protein?
Hormonally up-regulated neu tumor-associated kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Protein: Y2367_PECAS
Sequence: MFCVIYRSVKRDQTYLYVEKKDDFSRVPEELMKSFGAPQLAMVLPLNGRKKLANADIEKVKLALQEQGFYLQVPPPVESLLTTPV
What are the official names of this protein?
YcgL domain-containing protein ECA2367.
Protein: NDK_IDILO
Sequence: MALERTLSIIKPDAVAKNLIGAIYNRFESAGLRIVGAKMMHLSKEQAEGFYAEHKERPFFGALVEFMTSGPIVVQVLEGEDAVRKNRDIMGATNPAEALAGTIRADYAETIDENAVHGSDATESAAREISYFFSDEEVCQRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y036_MYCPN
Sequence: MKTLHKLLLGLFLPAILGPLFGLLVTKTDAESPVAALHKSKSFSKNLDSFRALFVGEDIEEQLAKVQQQTPEVSFASFQQKFPDKASLRNGFQPIDVYNFLSGWKGALENFLAKVVELQKKIKAADDIFPNQKKNPDKKDNPNVLEVLGEYGGDGFFPTLGNNGLNIPDQVFQSFNNFQIENYKISDFKVDIASERDIVQHDKFRFSYVVNIGLELALLVNKRPVYFNFSLDLRTNNFSNQAGFNEIFNAPGNAATNWQFFSKVKVKQLNYDGNDSTHLANTLLQDQFNTLNLNLQKSIYELPLTEMETKFQQEYVELLLAKRREEKRLWDEEQKRIEAERKQKEAELARIQRELKEKAEKDAAVKQAQTNLKTALSSVEGFVKFWTEGEDRIKLGFTKEDNLYTRAGLVKALKISFANYRAWTFYITLLGWKAGSEKLLRKTSWTNLLSDVNFQNAFGLKNTASEEQVGKTSLPGYGYYGIRMSNWLRWALGYYANTHVGSPQNVKATIDGNPSDTTKVWIAPEDFKQGVHIGVGEHFKGKAYKFKFEVSFELEGSIAAHWWTLALRGNIPGYWKGKLQVTHTFDGDVPSWYYGSVHTHAPEYRFTEDNKLLFVPHSIQKITAVGGDSNGVNGLLKSQNLHNLERQSYEVTAPIDLVSYLMFAIAKEPTNNW
What are the official names of this protein?
Uncharacterized protein MPN_036.
What is the protein family that this protein belongs to?
Belongs to the MG032/MG096/MG288 family.
Protein: MADC_MALRU
Sequence: MAKWTELQDKSFLEATARERAVGIVDEGTFTEFCGPFDKIYSPHLPLMGEAIEYDDGLVAGVGKIGKKPIFVISQEGRFIGGSIGEVSGAKMVKTIQLASDLYEEMVSEKPDLPEEMRPAVVISFETGGVRLHEANAGLLAHAEVMDQIQNCRGRVPIISLIGSRVGCFGGMGFVAAATDVIIMSQFGRLGLTGPEVIEQEMGKDEFDASDRALVYRTTGGKHKYIIGDCNYLAADSIRSFRETTTAVLQKPMEEIETFRRIGSMEKIKEQIELVKLSVSLKPKDSMDVWAHAGNENPESLINMTLDEFLAQAKRLKA
What is the function of this protein?
Gamma subunit of the biotin-dependent malonate decarboxylase multienzyme complex (EC 7. 2. 4. 4).  The two subunits MADC and MADD are required for the transfer of the malonate carboxy group from the acyl-carrier protein (ACP) to the prosthetic group of the biotin carrier MADF.  Required for the regeneration of ACP.
What are the official names of this protein?
Malonyl-S-ACP:biotin-protein carboxyltransferase MADC.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_TREPS
Sequence: MPKISIHEALFFELLGERCDDDTLERRLRSAKAELECSSFSVREDKEGGSLSPGGEVCDPVQRTRGQASCVREGAFDARLLKIELNDTNRPDLWSTAGLARLLRVHAGGASRAAQYRAFLSDRCTVRDSYGRCVVVDARLQTIRPFIAGFVARGTGLSEVRLWDLIQTQERLASNFGRRRCTLSLGCYRAQDICWPLAYRAVLLAEVSFTPLGMSMPLSGEQILTQHPKGREYGHLLKDYSFVPLLVDARGEVLSLIPITNSASLGAVVTGDTELFIECSGTDMCAVLVAVNSLACDLSDMGMQIEPVQITYSFDTPWGRSVTTPFYFQEKREVAHEQIDRLLGMPLPVADITEAFARMDCAVQVKQGTYVVEPAAYRNDFLHAVDLIEEVMLGRTLDRFSPQVPCSFTVGRLSDLTLLTRKIKHLLVGFGYQEMIFHYLGSAREFCTRMRCTADDLIEIENPLTESYRFVRRSIIPCLLSAELKSAHALYPHRIFEIGKVAFCSPHGEHGTCTQQSLGFLNASQEASYNEVASLVSGLLYCLKLPYQVEEAQDPRFVLGRQASICVHGSRVGIFGEIHPQVLSNWDIRMPCFAGELDVGALLP
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERFB_CANAL
Sequence: MVSPSSPESNDDDDLTNADSAITPATSTITTDSPTKSSFDDYQSLSSIRIPITRRITPSLSPQYEESNISTTTSATTTTTQQQHQQQQLQQQQQQLRQMSSLSASKIEQAKTDVLNNKKISFIHRFITNWLIMDPNLISHYNNTNTRRFKNYQIENQGQSNFIYFLGGRLHTIKTKYPINLITLSLIIIPGILYIIFELSWQWRNFSPIIVIIFLYIWIISIFHFFKLSTCDAGKLPKNIHLPKKLITITTTTTTTNDNEIDHRNNYKVMGSPPDEYFNTVTLPYWKTNNDNNDNTKISKLANAYHSHGVQVKYCGTCHIWRPSRTSHCNTCQQCILNHDHHCIFLNNCIGQRNYKFFLWFLLYIVIACLYLLIISILQLCHYKFASHKESEIITTFNQSIKTHPISLLLLIYSCLAICYPGLLLAFHIFLTSQNITTREYLNFVYKKPSKSTDGGDGTRGFVNVYNTHSIWENLYINWLGKSNGVSLTFPRDYYHQGDIRFANIEPLGTFTNK
What is the function of this protein?
The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.
What are the official names of this protein?
Palmitoyltransferase ERF2, DHHC cysteine-rich domain-containing protein ERF2, Ras protein acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: EIF3M_DROSE
Sequence: MTSHPVFIDLSLDEQVQELRKYFKKLGAEISSEKSNKGVEDDLHKIIGVCDVCFKDGEPSQIDGILNSIVSIMITIPLDRGENIVLAYCEKMTKAPNLPLGKVCLQSLWRLFNNLDTASPLRYHVYYHLVQVAKQCEQVLEVFSGVDQLKSQFANCPPSSEQMQKLYRLLHDVTKDTNLELSSKVMIELLGTYTADNACVAREDAMKCIVTALADPNTFLLDPLLSLKPVRFLEGDLIHDLLSIFVSEKLPAYVQFYEDHREFVNSQGLNHEQNMKKMRLLTFMQLAESSPEMTFETLTKELQINEDEVEPFVIEVLKTKLVRARLDQANQKVHISSTMHRTFGAPQWEQLRDLLQAWKENLSTVREGLTSVSSAQLDLARSQKLIH
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit M, eIF3m, Transport and Golgi organization protein 7, Tango-7.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit M family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus.
Protein: WDR59_MOUSE
Sequence: MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANYLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHIFATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNASDLNAPVHTFVGHDDVVLEFQWRRQKEGSKDYQLVTWSRDQTLRMWRVDYQMQRLCANDILDGVDEFIESISLLPEPEKTPHPQDIDHQPSLSHGEEDAIKEDPPSSLLEEKRSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVTFPAQYPNNAAPSFQFINPTTITSAVKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALQNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRPIKAAGKVIIQDVSCLLPVHKSLGELYILNVNDTQETCQKNATSAMLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLWGDRESTRVCGPPLSGARLAHYCQLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSHSRYPSFTSSGSCSSMSDPGFNTGGWNIAGRETEHISSPWGESSPEELRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF
What is the function of this protein?
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway.  Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex.  It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.
What are the official names of this protein?
GATOR complex protein WDR59, CUL4- and DDB1-associated WDR protein 12, WD repeat-containing protein 59.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR59 family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: MHPB_ECO81
Sequence: MHAYLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGAGGLSHQPPVPELAKADAHMRDRLLGSGKDLPATERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISAFGNWRSEGRYYRPIPEWIAGFGSLSARTEN
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: RPPH_POLNS
Sequence: MLDREGYRPNVGIVLLNSRNEVFWGKRVGQHSWQFPQGGIQHGESPEQAMYRELHEEVGLLPEHVQIIGRTRDWLRYDVPEEYLRRQNSTRVHRAAYRGQKQIWFLLRLVGLDSDIQLRAFEHPEFDAWRWVPFWIQLDAVIGFKREVYQLALSELARYLSRGMRMQQLAWGTPLDLFQSFYAGNEDQSKSSEKSDK
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: CLPX_LEIXX
Sequence: MARIGESADLLKCSFCGKSQKQVQQLIAGPGVYICDECVELCNEIIEERLAEAGEEASSEFDLPKPKEIFGFLEEYVIGQEQAKRSLAVAVYNHYKRVRARQAITAADAIDDVEIAKSNILLIGPTGCGKTYLAQTLARRLNVPFAVADATALTEAGYVGEDVENILLKLIQAADYDVKRAETGIIYIDEVDKIARKAENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTTNVLFIVAGAFAGLEDIISNRAGKKGIGFGAPLHSKGDDINLFSEVLPEDLHKFGLIPEFIGRLPVVTTVTQLDQDALMQILTEPKNALVRQYQRMFELDGVQLEFDHAALEAIADLAVLRKTGARGLRAIMEEVLGPIMFEVPSSSEVARVVVTKEAVLENAAPTIVPHRPRREEKSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TOR2A_RAT
Sequence: MAVARHGCPPWGSILGLLVLALAAAAAWDVSFLRCSLGSFCECDFWPDLPGLECDLARHLAGQHLAKALVVKSLKAFVQDPAPSKPLVLSLHGWTGTGKSYVSSLLAQYLFRGGLRSPHVHHFSPIIHFPHPSHTEQYKNELKSWVQGNLTACGRSLFLFDEMDKLPPGLMEVLKPFLGPSWVVYGTNYRKAIFIFISNTGGEQINQVALEAWRSRRDREEISLQEVEPAVSQAVLDNPHHGFWRSGIMEEQLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPREEVVQAVLDSTTYFPEEEQLFSSNGCKTVASRITFFL
What are the official names of this protein?
Torsin-2A, Torsin family 2 member A.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. Torsin subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: FLHD_ACISJ
Sequence: MTSEQLLAEIREANLTYLMLAQTLIRQDKAEAVFRLGLNEEAADILASLSAAQVLKLASRNTLLCSFRVDDELVWSLLTSHNTPRKAASEATNTLHANILMASRVSEVL
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECY_STAA8
Sequence: MIQTLVNFFRTKEVRNKIFFTLAMLVIFKIGTYIPAPGVNPAAFDNPQGSQGATELLNTFGGGALKRFSIFAMGIVPYITASIVMQLLQMDIVPKFSEWAKQGEVGRRKLNNVTRYLAISLAFIQSIGMAFQFNNYLKGALIINQSIMSYLLIALVLTAGTAFLIWLGDQITQFGVGNGISIIIFAGILSTLPASLIQFGQTAFVGQEDTSLAWLKVLGLLVSLILLTVGAIYVLEAVRKIPIQYAKKQTAQRLGSQATYLPLKVNSAGVIPVIFAMAFFLLPRTLTLFYPDKEWAQNIANAANPSSNVGMVVYIVLIILFTYFYAFVQVNPEKMADNLKKQGSYVPGIRPGEQTKKYITKVLYRLTFVGSIFLAVISILPILATKFMGLPQSIQIGGTSLLIVIGVAIETMKSLEAQVSQKEYKGFGGR
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COAE_BACCZ
Sequence: MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFHNEEKRLQLNKIVHPAVHEEMNRQKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQSQMSLEEKVKNADEVINNDGTIMGTKTQLQAILKKWNIID
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_HAEIN
Sequence: MSKSLVIVESPAKAKTINKYLGSQYVVKSSVGHIRDLPTVGSSTGEKAKPISTKGMDAEEKAKIKAEKERNALVKRMGIDPYHDWKANYQILPGKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGNDDRFSRVVFNEITKNAIKQAFEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWEVAVLTNNQNKQAIRLDVTDYKGKKFDPKNQKEAQSAVDFLNVSDYVVTDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMARTYIENHFGAQYLPEKPNFYSSKENAQEAHEAIRPSDIRALPESLEGMEKDAVRLYDLIWCQFLACQMPPAQYDSSTLTVTAGDYTLKAKGRILRFDGWTKVLPQIGKNPEDQELPSVTVSEKLALKEVQPTQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNESFGELMNYDFTANMEDTLDKIASGSVNWKTELNQFFKDFSSQLSKAELDELEGGMRPNSLVETDIKCPTCGRNMAIRTASTGVFLGCTGYALPPKERCKTTINLIPEAELLNVLDESSETKALMDRKRCTKCGTAMDSYVIDAHRKIHICGNNPNCDGYLIEEGSFKIKGYDGPVVECDKCGADMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPVKIAELVQYRERLPEKLAYLADAPQKDPEENEAIVRFSRKEKKQYVTSEKEGKATKWIVDFTNGKWVERKK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.