PharMolix/UniProtQA huggingface dataset:
Protein: LSM12_MOUSE
Sequence: MAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEIINDRTETPPPLASLNVSKLASKARTEKEEKLSQAYAISAGVSLEGQQLFQTIHKTIKDCKWQEKNIVVMEEVVITPPYQVENCKGKEGSALSHVRKIVEKHFRDVESQKILQRSQAQQPQKEAALSS
What is the function of this protein?
Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein.  Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release.
What are the official names of this protein?
Protein LSM12.
What is the protein family that this protein belongs to?
Belongs to the LSM12 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Colocalizes with TPCN2.
Protein: UREE_STAAR
Sequence: MIVEEIQGNIANLSNSEKQKHVEKVYLENSDLVKRIQRVVTDHGTEIGIRLKQPIDLQYGDILYADDHNMIVVDVNSEDLLVIQPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVEDLLKSLGIPYVREDRKVNKAFRHIGHSHD
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTAC5_ARATH
Sequence: MASSSLPLSLPFPLRSLTSTTRSLPFQCSPLFFSIPSSIVCFSTQNPDREEVRWLREEQRWIREEQRWIREEQRWIRERESLLQEISDLQLRIQSLESRNSQLGNSIPDTISNIAALLQVLKEKNRISESGLSATPMVLESTREQIVEEVEEEEKRVIIAEEKVRVSEPVKKIKRRILKVGSEGDDVQALQEALLKLGFYSGEEDMEFSSFSSGTASAVKTWQASLGVREDGVMTAELLQRLFMDEDVETDKDEASTMKKEEAGNGAVFTSVTQVPEKKQSIVKDQSDREVDVTQNRVFLLGENRWEDPSRLIGRNKPVDRSESTNTKTRCITCRGEGRLMCLECDGTGEPNIEPQFMEWVGEDTKCPYCEGLGYTVCDVCDGKKNL
What is the function of this protein?
Exhibits zinc-dependent disulfide isomerase activity.  Required for seedling and chloroplast development under heat stress, probably by maintaining plastid-encoded RNA polymerase (PEP)-dependent transcription.
What are the official names of this protein?
Protein disulfide isomerase pTAC5, chloroplastic, Protein PLASTID TRANSCRIPTIONALLY ACTIVE 5, pTAC5.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma, chloroplast nucleoid.
Protein: PRMC_BACSU
Sequence: MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASLQEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFHLLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAEKLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDGGDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGKDRTICALIHKNK
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: TRPD_SYNC1
Sequence: MIRQAIARVVEGQNLKESDMIEVMNQIMGGEATPAQIGALIVALRMKGETVEEITGAARVMRDHATPVRVGRVLDIDREEINLDQETMAAVLDTCGTGGSGTKSFNISTTVAFVVAACGVKVAKHGNRSVSSMCGSADVLEALGVHLDIGVDTVERCIAEEGIGFLFAPALHGAMRYAIGPRREIGIRTIFNILGPLTNPAGADRQVLGVYREDLVATLADVLCRLGCRRGFVVHGMDGMDEVTLTAPTRIADIREGRYSLSTIAPEDYGLQRCRLEDLAGGDARHNAELVRGILAGEAGPRRDIVLLNSAFALVAAGKADSIEDGMRAAAQAIDEHAALAKLNALIRMTQP
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: MFHA1_XENTR
Sequence: MAGNDTCNNSCDVKTARLWRDAALRSRKLRSSLRQLTLSCVDKRKLILPADLGDVEVLNLGNNSLEEVPDGLQSLSAGNLHVLILRRNKFLNVPTAVYHLGRLTELDISYNRLSCLTEAVGLLGKLKKLCLSHNQLRTLPRQLGMLVDLEELDVSFNQITHLPDTMQGLPSLRTLDLDHNELCSFPQQLFHVPALEELDFSGNKMLGSLPEGIRSMQSLKILWLSSTSLCLLPDSICELVNLESLMLDNNNLHTLPEGFGALQKLKMLNVSSNAFQDFPVPLLQLVDLEELYMSRNRLVVLPEVISCMTKLVTLWLDNNRIRYLPDSIVELSFLEELVLQGNQIAILPDDFGKLSKVNIWKIKDNPLIQPPYEVCMKGISYIAAYQKELAHSQPAVKPRLKLVLLGLKDAGKTLLRQCLTDEQNTSTLVQGYKGIEITNWTADAERGLAFIVYDLAGDQSYDIIKPFFFSPGALYILVVNLKSYVCKHFYTHVGYFIHLITSKVPHAVVCIVGTHIDLCNEKELEEKCLDIHHQIAVQEKRDSETLQTLIQTVDKALSQDFDFRASNPHSAFYGVSDKNLRRKKTHFQYLMNSRLQILSPVLCVSCLDFSNIKRLREKLLSVAEHREIFPNLHRVLPKSWQMLEELHFKPQELWLTWWDSARLGLQAGLTEDRMQSALSFLHESGKLLYFEDNQTLKEYVFHNLTKLIDILNVFFQRDASVLFAKLTSDATADETKVTQFHHYVEGFLLHGLLPTHIIRSLLKPHIKTHQDLQLILELLEKMGLCYCINKPKNKLLNGATVWYKFPCYVKNEAPHAEAWINGTNISEPCLAVEQLQIEYSFPFIFPPGLFARFSVQINSHIVHRSDSKFQIFAYRGKVPVVVSFQPARGALQPGILSIASHASLPNIWTAWQAITPLVEELNALLQEWPSLYYTVHVLCSKCLKRGSPNPHPFPGELLSQPRPDGVTELICPKNGSERLNVSLVYPPTPTMISPCSK
What is the function of this protein?
Probable GTP-binding protein.  Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways.
What are the official names of this protein?
Malignant fibrous histiocytoma-amplified sequence 1 homolog.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSK_LACPL
Sequence: MARRQATTKKRRTSTRKKKPTVAAKRQMTGNVIGLIGLLVTILALLKVGLVGMVFAEFFRAIAGNAYQIFAGLTLLVMGYLMIFGRWPRLTWRWWVGGNLFFFSYLLLLEIPMFNQLNHHTDFWSLTWNLIKNDFAKGGMASNLGGGLVGAAGYSVTYPLLANVGTILIALILMVASIYITFDLPFHKTMQALRQALMQLGQQLRSGYEWLTHVLRVQIARWRVHQQVRANQAASTEKQPTSTVPQSAAPAETTSGTSAPDSAASAVTSSPADLNITVASDREASPIKSPTSAATVDHEQELQGTEVMDDADYQLPESTLLTKIPKTDQSAEYATIESNSQKLTTTLASFGVQVEVKNVSLGPSVTKYELHPAVGVKVSKVVNLADDLALALAAKDLRIEAPIPGKSLIGIEVPNKQISTVSFRDIVEAQPAHPTKPLAVPLGRDVSGNLVVADLSKMPHLLIAGSTGSGKSVAINVMITGLLMNTKPSQVKFMLIDPKKVELGVYNGIPHLLTPVVTEPKKAARALHKVVAEMERRYELFADSKQRNMQGYNQYIRQQNAADGQSRPVLPYIVVVVDELADLMMVTSSEVEDAIIRLGQMARAAGIHMILATQRPSVDVITGLIKANVPSRMAFAVSSGTDSRTIIDSNGAEKLLGRGDMLYQPMGMNKPLRVQGAYISDHDVEEVVNFIKAQQTADYDDSMLVKDDETDAAGSGDPRDGEDEYYAEAVELVTDQQSASVSMLQRRFRIGYNRAARIVDEMEERGVVGPSEGSKPRKVYRQKSADEAPASGNDA
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: RNPA_ALIF1
Sequence: MNYDFSRELRLLTPEDYKFVFKQAHRAGSPHFTILARENSLSHPRLGLAVPKKQIKTAVGRNKFKRIVRESFRNKQHSLPAKDFVVIAKKSAQELSNEDFNKLLDKLWHRLSRPSRG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: EFG_RICRO
Sequence: MSKINKLEHIRNIGICAHIDAGKTTTTERILYYTGKSHKIGEVHEGGATMDWMEQEQERGITITSAATTCRWQDKIINIIDTPGHVDFTIEVERSLRVLDGAVAVFDGVAGVEPQSETVWRQADKYNVPRMCFVNKMDRMGADFYRCVEMLKDRLGAKPLVIQLPVGIEENFKGIIDLIKMKAVIWKDEALGAEYFEEDIPADMKDKAEEYRAKLLDMVVELDDHVMEKYLSGEEVTAEEIKRLIRKGTISAAFYPVLCGSAFKNKGVQPLLDAVVDFLPSPIDIGIVKGMEVSTGEETDFPISVTEPFAALAFKIMNDPFVGSLTFIRIYSGKITSGTTVINTVKNKREKIGRMLLMHANNREDVKEASAGDIVALAGLKDTTTGDTLSDIDQQVILERMEFPEPVIELAVEPKSTADQEKMGLALSRLAAEDPSFRVSTDYETGQTVIKGMGELHLEIIIDRMRREFKVEANIGAPQVAYRETITKVCEIDYTHKKQSGGAGQFARVKIIFEPLKEVKDLKDEDKNKNFVFESKIIGGAVPKEYIPGVEKGLNNIRETGVIAGYPMIDFKATLVDGAFHDVDSSVLAFEIAAKAAFREGMPKGNPKLLEPIMQVEVITPDEYMGDIIGDLNSRRGQIQSMDPRGNAQVVTANVPLAEMFGYVNTLRSLSQGRAQFSMIFSHYDQVPSQVADIIKAKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CWP18_SOLLC
Sequence: STHTSDFLKL
What are the official names of this protein?
80 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: RL6_ANADF
Sequence: MSRIGKLPVKIPEKVKVSVDGNLVKVEGPKGKMSFPTNPRVKVAVDKGEVQVTRPDDSPESKGLHGLTRTLVKNALDGVVKGYERGLEINGVGFKAEVKGKEIHFALGFSHPVVFKLPEGVTAEVDAKQTKLTVKGVDKHVLGLTAAKIRALRPPEPYKGKGIKYAEEIIRRKEGKTGAA
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: PUR9_MYCTA
Sequence: MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLETLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: ATPE_STAA8
Sequence: MNTLNLDIVTPNGSVYNRDNVELVVMQTTAGEIGVMSGHIPTVAALKTGFVKVKFHDGTEYIAVSDGFVEVRKDKVSIIVQTAETAREIDVERAKLAKARAESHLENDDDNTDIHRAERALERANNRLRVAELK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: COAX1_FRATO
Sequence: MIVCIDIGNSHIFGGVFVGDQIKHNFRYPSTTPCTSDTLGIFLLSFFERKKLDIEDIEAVVLSSVVLHLEYSVNSACKKYLGITPLELKPGVKTGLKLDIKNPLDLGADRVANSVAAISLFPSRNIIVVDFGTATTICAISENKTYIGGAILPGINLSMESLSQKTAKLSNVTISHPSSALGKTTISQIQSGLIYGQLGAIKEIINRISQENFIDKPPILIATGGYAHIFEKEQYFDVIISDLLLHGLRIIWQMNK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase 1, PanK-III 1, Pantothenic acid kinase 1.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPA_MYCVP
Sequence: MSTGLAGILFLASLVIALVAVHVPLGDYMYRVYNTAKDSRAENVVYRLIGADPKAEQTWGAYARSVLAFSAVSLLFLFILQLVQGRLPSALTDPGTPMTPALAWNTAVSFVTNTNWQAYSGESTHGHLVQMAGLAVQNFVSAAVGMAVAIALVRGFARKRTGELGNFWVDLVRGTIRILLPISVIAAILLITGGAIQNFHNYDQVVNTLAGAQQTIPGGPVASQEAIKDLGTNGGGFYNVNSAHPFENPTTWTNWIEIFLLLVIAFSLPRTFGRMVGNKKQGYAIVGVQAVLAVISWSATLFFQLQAHGTVPTAVGAAMEGVEQRFGVANSAVFAASTTLTSTGSVDSFHDSYTSLGGLVLLFNMQLGEVAPGGVGAGLYGILILAVITVFVAGLMVGRTPEYLGKKITPREIKLAATYFLVTPLIVLTGTAVAMAMPGQRAGMLNTGPHGLSEVLYAFTSAANNNGSAFAGITVNTEWYNTALGLAMVFGRFLPIILALALAGSLAQQGKTPPSIGTLPTHRPQFVGMVAGVTLILVALTFLPMLALGPLAEGIH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPXK_CHLP8
Sequence: MSSRSASFLLRPAAALYGVVMSLRNHLYDRGAFKSWRSPIPVVSVGNITTGGTGKTPLVDWIVKFYEASGIPTAIVSRGYGRQTKGVQLVSDGKRILLGSRDAGDETAMLASRNPGTIVVVAEERVEGVQFLMREFADRLPGVIVLDDAFQHRKIARDLDIVVVNAGTPQELDAMLPAGRLREPLPGLSRADLIILSKITDDAKAAPLLQKLRETGKPVLRSKIKPGKLVKVDGSENGATEPAVKALAFAGIGAPEGFLHSLEKAGITVKATKFFRDHEPYTEAAIRSIIEESKRQEFVPVTTEKDWFRIADNPQLTEMLAQAGCRYLTIAPEFLDGTEELEKRLLSVLETKVVNWPLSPP
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: QUEC_SALNS
Sequence: MKRAVVVFSGGQDSTTCLAQARHQYDEVHCVTFDYGQRHRAEIDVARDLALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPNADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVNLGMAKDIRFETPLMWIDKAETWALADYWGQLDLVREETLTCYNGIKGDGCGHCAACNLRANGLNHYLSNKAAVMAAMKQKTGLR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: PSB1_THESM
Sequence: MWALDKIKGTTTVGIVCKDGVVLTADRRASLGNMVISKGVTKIFQVDDHLALAGAGAVGDILSLVRALRAESKLYRAKVGKEMSTKALATLTSNILSGRKYLPYFGWFLIGGYDEKPSLYSIDMAGGITEDKYVSAGSGMEFAYSILDNEYSEKITLNNGVKLAIKAINAAIKRDVFTGDGIMVVTIDREGYRELSKEEVEKLLKKL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 1, 20S proteasome beta subunit 1, Proteasome core protein PsmB 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCAF_DANRE
Sequence: MAREQDYYTLMSGMQQLDLQGKAVPSDLVLIGEHAFPLAMNPRGQVLMAASHYGRGRIVVLGHEEYLTRFPGLIENAIMWLMPCTGDAGVVGIQKSLRTVAENLNYSPFKTELGDFQDRFAIYITDAYSVESSAKDLIAFLKAGGGLIIAGQAWSWSYEHPQENTIRNFPGNKVCSVAGIYFSELEGEVGTFPVPRNIPSSWLAVAIGKDFKEDLEFLLEGVSEFDTQGGAIASEVMVHGPLAFPIAVTPNGKTFIAGAYYGQGRVIVVSHEGYMGRDSLSSFMINAIKWLDEGRKGVVGIVPNLTAAHTVLSKSGLDCQLTGFREDLSVYVCTSYSDAQCAEIQEFVAEGGGLLIGGHAWYWAQTHCGSNVMTEYPGNHILNKMGLCLLGNTLGGGLYKAPEIEHSCKHGYHFRSMLQRFAQHVSQGQELTDREQGCLKQLGTDCASYLQMRCHDSAAYTSVVALLSDIVKEVGVPQVCSNCPVESPKDHLMLHIGTEVYKVTPDPDALLPYIIKDRPNLPTLSNARVRITANTGGCEEWISTGLYLSPGMKTYIAVPPEIVGKNWQVQLGCQTDNIGGSNTLKRAPVVHARFPLDSEMVQVWNLWGGLIYLIAPSQTKVDGVEIVVQNAVQAPYFKSGETSVADWVSHIRQAPAPWAELEFENLIMTFDSAFIRNLDRPDEVAKLWDTIMRTITDLAARPPKLPRKERFVADVQISYGFMHAGYPIMMHSGSAPGLVNVEEAYKCGLWGAIHELGHNQQRGVWEFPPHTTECTCNLWSLYVHEQVFGIKSANAHPAITPADRQARTKMYFDGGKDLNSWCMWMALETYMQLQEKFGWDAFKKVFSLYHDMTGVPNDNAGKMNLYAQTFSKVVNLNLSPFFKAWGWPIQPNTEQNLSHLPAWSDHPVSQYA
What is the function of this protein?
May play a role in the regulation of the cation channel TRPM8 activity.
What are the official names of this protein?
TRPM8 channel-associated factor homolog.
What is the protein family that this protein belongs to?
Belongs to the TCAF family.
Protein: PRIO_ATEPA
Sequence: MANLGYWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQAGGTHNQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYNNQNNFVHDCVNITIKQHTVTTTTKGENLTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: CIDB_STAAM
Sequence: MNDYVQALLMILLTVVLYYFAKRLQQKYPNPFLNPALIASLGIIFVLLIFGISYNGYMKGGSWINHILNATVVCLAYPLYKNREKIKDNVSIIFASVLTGVMLNFMLVFLTLKAFGYSKDVIVTLLPRSITAAVGIEVSHELGGTDTMTVLFIITTGLIGSILGSMLLRFGRFESSIAKGLTYGNASHAFGTAKALEMDIESGAFSSIGMILTAVISSVLIPVLILLFY
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
What are the official names of this protein?
Holin-like protein CidB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. CidB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PANE_AQUAE
Sequence: MVMKFLIVGVGAIGSAYLAFLTRAGHEAAGLVRRNPVNRIKVEGIWGEFEIPVKTFTKVEEVPFIPDIVIISVKSYDTEEALKKVKPVVGENTFIMIAQNGYGNYEKAVEIYGEGKVILSRIIFGSKVIKPGHIRITVSADEVVIGDPSGKIDEEFLKNLARTFTEAGIPTRYERDVYKYLVDKIIYNSALNPLGALFEVNYGSLAENPHTKELMNRVIDEIFQVIEKAKLPCFWKSADEYKKVFYEKLIPPTAEHYPSMLEDVKKGKTEIEALNGAIVELGKKYGVSTPTNEFITKMVKAKELFNLKDT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
What are the official names of this protein?
2-dehydropantoate 2-reductase, Ketopantoate reductase, KPR.
What is the protein family that this protein belongs to?
Belongs to the ketopantoate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_SPIAP
Sequence: DSGLGKTHLLKAIAHEIGNTKNKLVVKYYTSSDFRKEIVDSLQDGFKEIESTKEKLSKIDVLLIDDIQFLANSGKTNEIFFNLFNFFIENNKQIVLTSDKFPEQLNGFDKRLVSRFSQGLNVKVETPDIITAINIVDYKAKIVNLNLSEESKKYIASFFGSDVRKIEGIINKIEFSIIQDNSAAPKIIELEDINKFLEDYSFAPGGEITVQKIKNVVAQNYGISVKSIDSRLRMANIVKARHVAMFLTGEILKKNYSEIGVAF
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPXM_BACSH
Sequence: MTNQTARSSKKERYANLIPMEELHSEKDRLFPFPIYDKLRRESPVRYDPLRDCWDVFKYDDVQFVLKNPKLFSSKRGIQTESILTMDPPKHTKLRALVSRAFTPKAVKQLETRIKDVTAFLLQEARQKSTIDIIEDFAGPLPVIIIAEMLGAPIEDRHLIKTYSDVLVAGAKDSSDKAVADMVHNRRDGHAFLSDYFRDILSKRRAEPKEDLMTMLLQAEIDGEYLTEEQLIGFCILLLVAGNETTTNLIANAVRYLTEDSVVQQQVRQNTDNVANVIEETLRYYSPVQAIGRVATEDTELGGVFIKKGSSVISWIASANRDEDKFCKPDCFKIDRPSYPHLSFGFGIHFCLGAPLARLEANIALSSLLSMSACIEKAAHDEKLEAIPSPFVFGVKRLPVRITFK
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 109, ORF405.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: QPCT_BOIIR
Sequence: MAGERRDSKAAAFFCLAWALCLALPGFPQHVGGREDRADWTQEKYSHRPTILNATSILQVTSQTNVNRMWQNDLHPILIERYPGSPGSYAVRQHIKHRLQGLQAGWLVEEDTFQSHTPYGYRTFSNIISTLNPLAKRHLVVACHYDSKYFLPQLDGKVFVGATDSAVPCAMMLELARSLDRQLSFLKQSSLPPKADLSLKLIFFDGEEAFVRWSPSDSLYGSRSLAQKMASTPHPPGARNTNQIQGIDLFVLLDLIGARNPVFPVYFLNTARWFGRLEAIEQSLHDLGLLNNYSSERQYFRSNLRRYPVEDDHIPFLRRGVPILHLIPSPFPRVWHTMEDNEENLDKPTIDNISKILQVFVLEYLNLG
What is the function of this protein?
Responsible for the biosynthesis of pyroglutamyl peptides.  Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue.  Also catalyzes N-terminal pyroglutamate formation (By similarity).
What are the official names of this protein?
Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, QC, Glutaminyl-tRNA cyclotransferase.
What is the protein family that this protein belongs to?
Belongs to the glutaminyl-peptide cyclotransferase family.
What are the subcellular locations of this protein?
Secreted.