PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_BAUCH
Sequence: MIEADNLNVTSIITDYNPIVDYRPKKLVDYIGQTNVREQMKIFIQAAKMRGDALDHVLLFGPPGLGKTTLANIIANEMEGSLRSTSGPVLEKAGDLAAILTNLEPHDVLFIDEIHRLSPVIEEILYPAMEDYKLDIIIGEGPAARSIKIQIPPFTLVGATTRIGSITSPLRDRFGIVQRLEFYPTKDLQNIISRSAANLSLSITDGGLSEIAKRARGTPRIALRLLRRVRDFAEVRAAGKITNNVAMNALNMLNVDTAGFNFMDRQLLLVIINKFLGGPVGLDNLAAAIGEERETIEDVLEPFLIQQGFLQRTPRGRIATAEAYRHFSLKQSRDI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: KUP_BURMA
Sequence: MTDTNHSSMRQHSLQSLAIAAIGVVFGDIGTSPLYSLKEAFSPAHGIPLTPSAILGVISLLFWAIILVVGIKYVLFVMRADNNGEGGVLALMALSLRPLNPKSRITGLMMALGIFGACMFYGDAVITPAISVMSAVEGLEVATPQLSHLVLPITIVILIALFWIQRHGTATVGKLFGPIMLLWFVTIAALGIYHIARAPMIVSAINPYYAFSFMSEHVLLAYVVLGSVVLVLTGAEALYADMGHFGAKPIRLAAYVLVMPSLVLNYFGQGALLLLDPKAIENPFFLLAPQWAALPLVVLSTVATVIASQAVISGAYSLTSQAIQLGYVPRMKILHTSELAIGQIYVPVVNWLLLFVILCIVIGFKSSDNLAAAYGIAVTATMVITTILAAVVMVKVWNWNKLLVAMIIGVFLVIDLGFFGANLLKVEQGGWLPLGIGALLFFLLMTWYKGRHIVKERTAADGIPLAPFLQGLLAHPPHRVSGTAIYLTGNDTLVPVSLLHNLKHNKVLHERTIFMTFVTRDIPYVKDHERVTVHDAGEGLYIVKAEYGFNETPDVKAVLEEVARQRGMTFELMDTSFFLARETVVPTHLPGMSIWRERVFAWMHQNAAKPTDFFAIPANRVVELGTKIEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACCA_AQUAE
Sequence: MILFKVMHLEFEKELLEIKEKIDRLLGLYRLGKEEVLSELDELRKKFKEKARKIYRDLSPWERVQVARHPKRPHTSDYIKYLIKDFEEVHGDTCYGDDKAVIAGFGYFRGKPVAVVGHEKGKDTKEKLERNFGMPHPEGYRKAIKVFKLAERYNIPVITFIDTPGAFPGIGAEERGQSRAIAESMLTMAFLKVPSVAVVIGEGGSGGALAFGVANRVCILENAYYSVISPEGCAAILWKDQSKVKEAAKALRLTAKDLKELGVVDCVIPEPYGAAHWSPRGTAMMVGMTLKKCLDELSKLTEEGVVRSRLEKFKNMGAFKIAS
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B3A3_PONAB
Sequence: MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEETPPIQEEGGAGVEEEEEEEEEEEGESEAEPVEPPPSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPQTDKSPQHSSSSPSPRAQASRLAGEKSRPWSPSASYDLRERLCPGSALGNSGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPSSSSMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGGDGHRGKSLKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVCFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDAGLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTPPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFICIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMPV
What is the function of this protein?
Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane.
What are the official names of this protein?
Anion exchange protein 3, AE 3, Anion exchanger 3, Solute carrier family 4 member 3.
What is the protein family that this protein belongs to?
Belongs to the anion exchanger (TC 2.A.31) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS19_MYCA9
Sequence: MPRSLKKGPFIDDHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHIKDDRKSKRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: PSAG_HORVU
Sequence: MATSTAAVLSPPAVAGLRLAPSPRAAASFRGVSPPARRSVAARAALEPSVVISLSTGLSLVMGRFVFFNFQRENVAKQVPEQNGKTHFEAGDERAKEFAGILKSNDPVGFNLVDVLAWGSIGHIVAYYILATTSNGYDPPFFG
What is the function of this protein?
Not yet known.
What are the official names of this protein?
Photosystem I reaction center subunit V, chloroplastic, PSI-G, Photosystem I 9 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsaG/PsaK family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PYRF_PSET1
Sequence: MPFEKSKKILIALDYDDQQAALDFVKQLSPDSCRLKVGKEMFTYFGPAFVKELIDLGFDVFLDLKFHDIPNTVAKAVTAAAKMGVWMVNVHASGGFEMMSKAKQALAPFGDKAPLLIAVTVLTSMDETELKRLGVEKTPQEQVIYLAKLAKEAGLDGVVCSAQEAQQLKAELGAGFKLVTPGIRPVGSDAGDQKRIMTPKQAIDAGSDYLVIGRPITQADNPVAVLADVNKSIE
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: GLO3_CAEEL
Sequence: MFGYVVVNEQNSIVFLDGNEEFKTIFQSLIQSEITSRKSDLDSASSGVGSSTCTEEQESSLDHFKKPNVVFNSSEISHILLPLILLYRSTSEKTKDPITEMSSQFGTISISKFYHNYLVLVFANDDRKRIEVSQTIEHTIATLFGPLIAFCHTDLTTVKKPKEHLACALTRKLSYSPKC
What are the official names of this protein?
Gut granule loss protein 3.
Protein: ZNTR_ECO57
Sequence: MYRIGELAKMAEVTPDTIRYYEKQQMMEHEVRTEGGFRLYTESDLQRLKFIRHARQLGFSLESIRELLSIRIDPEHHTCQESKGIVQERLQEVEARIAELQSMQRSLQRLNDACCGTAHSSVYCSILEALEQGASGVKSGC
What is the function of this protein?
Zinc-responsive transcriptional regulator of zntA.
What are the official names of this protein?
HTH-type transcriptional regulator ZntR, Zn(II)-responsive regulator of zntA.
Protein: TA2R_HUMAN
Sequence: MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
What is the function of this protein?
Inhibits adenylyl cyclase.
What are the official names of this protein?
Thromboxane A2 receptor, TXA2-R, Prostanoid TP receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS5_LEIXX
Sequence: MAAEVTETAQPVETAASTDNNREQREPRRGGRERNPNRDRGNRDADKSQFLERVVTINRVSKVVKGGRRFSFTALVVVGDGNGLVGVGYGKAREVPLAISKGVEEAKKNFFRVPRVANTIPHPVQGEAAAGVVLLRPAAAGTGVIAGGPVRAVLECAGIHDVLSKSLGSSNTINIVHATVEALQQLEEPRAVAARRGLDYDRVAPEKLLQIEARAAEAAAAAKKAGAEKVGA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: LPXC_THEYD
Sequence: MPFQKTIKSEISLTGIGIHTGKKINLNLIPAQRDTGIVFYRKDRNFPIKAKLPFVVDTSFATTLGVDGIKIRTVEHLLATLHVFGITNVFIEIDSSEIPVMDGSAIDFTKAILKAGIAKQGKTVSLFKITKPVYYEESHSKIFAKPYRGFKITYKIFYEHPLIMEQSLSIEINEQNFLNDIAPARTFGFLKDINYLLKNGFAKGGSLDNALVLDEKGVVGGNLRFKDEFVRHKILDAIGDLSLIGYPIQGHFIIEKGGHTSHINFLRKLIETGCYELAEEPYFNFQLSAQAV
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: Y2202_STAAR
Sequence: MKDLTMLLHELKDMSFFNKGDICLIGCSTSEVIGEKIGTVGSMEVAETIFNALDVVSKETGVTFAFQGCEHINRAITIEKSQFNPLTMEEVSVVPDVHAGGSLATYAFQHMKDPIVVEHITVPCGIDIGQTLIGMHIKHVCVPVRTSVKQVGQAIVTIATSRPKKIGGERAKYQ
What are the official names of this protein?
UPF0340 protein SAR2202.
What is the protein family that this protein belongs to?
Belongs to the UPF0340 family.
Protein: RL16_OLEA2
Sequence: MLTPKKVKFRKRQKGRLKGDALKGNNVAFGEIGLKVLEHGKLTSQQIEAARVAAMRHIKRGGKMWIRIFPDQPYTAKPLETRQGKGKGAPVGWYAPVKPGRVLYEIKGVNLELAREALTRAAHKLPVKTTIVVREGL
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: TRUA_BUCA5
Sequence: MVAKNVKTFALGVEYDGSYYHGWQRQKIVPSIQEEIEKALSIIANHKIDVVCAGRTDAGVHSIGQVIHFKTTANRKKSSWSIGVNSYLSENISVVWVKEVTENFHARYSAITRSYRYIIYNYSLRSAIFQTKLNHIYRKLNVDKMHFEAQFLLGEHDFTSFRALGCQSHSPWRNITKLNVFRFHNWVVVDITANSFLHHMVRNIVGSLIEVGISKKKEYWIKDLLEKKDRSHAGATAPAKGLYLVYVEYPLHFNLPRSAYTSIFFK
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: ARR11_ARATH
Sequence: MEKSGFSPVGLRVLVVDDDPTWLKILEKMLKKCSYEVTTCGLAREALRLLRERKDGYDIVISDVNMPDMDGFKLLEHVGLELDLPVIMMSVDGETSRVMKGVQHGACDYLLKPIRMKELKIIWQHVLRKKLQEVRDIEGCGYEGGADWITRYDEAHFLGGGEDVSFGKKRKDFDFEKKLLQDESDPSSSSSKKARVVWSFELHHKFVNAVNQIGCDHKAGPKKILDLMNVPWLTRENVASHLQKYRLYLSRLEKGKELKCYSGGVKNADSSPKDVEVNSGYQSPGRSSYVFSGGNSLIQKATEIDPKPLASASLSDLNTDVIMPPKTKKTRIGFDPPISSSAFDSLLPWNDVPEVLESKPVLYENSFLQQQPLPSQSSYVANSAPSLMEEEMKPPYETPAGGSSVNADEFLMPQDKIPTVTLQDLDPSAMKLQEFNTEAILRSLNWELPESHHSVSLDTDLDLTWLQGERFLANTGLQFQDYSSSPSLLSELPAHLNWYGNERLPDPDEYSFMVDQGLFIS
What is the function of this protein?
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'.  Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Could directly activate some type-A response regulators in response to cytokinins (By similarity).
What are the official names of this protein?
Two-component response regulator ARR11, Receiver-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-B subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: LGT_THET2
Sequence: MDPVMVQIGPLAIRWYGVLLTLAIFLGYELARRRLRAWGWDLEPFERVVFWAVVFGVVGARLGYVLTSPGYFLENPLEALYIWHGGLSFHGAILGGALTFYYFHRRRGYPLWPYLDAATPGVALGIVAGRIGNLMNGSDTVGRLTTLPIGFTWPEWARGFPGVCPGIDDISEVYRCAELLRGPVHLTQVYGAVVGLILLFLSLYWLRKRPFYGYAFWQFVLWYSVLRSVLEEPFRLNPLWLPVYRNDELGIGLFTATQVVSLPLVLLSLYMLRRLGKGEASRR
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NAOX_STRP6
Sequence: MSKIVVVGANHAGTACIKTMLTNYGDANEIVVFDQNSNISFLGCGMALWIGEQIAGPEGLFYSDKEELESLGAKVYMESPVQSIDYDAKTVTALVDGKNHVETYDKLIFATGSQPILPPIKGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKLENKDIKRVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVAGNGKVEKIITDKNEYDVDMVILAVGFRPNTTLGNGKIDLFRNGAFLVNKRQETSIPGVYAIGDCATIYDNATRDTNYIALASNAVRTGIVAAHNACGTDLEGIGVQGSNGISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKPEFIEHGNFPVTIKIVYDKDSRRILGAQMAAREDMSMGIHMFSLAIQEGVTIEKLALTDIFFLPHFNKPYNYITMAALGAKD
What is the function of this protein?
Catalyzes the four-electron reduction of molecular oxygen to water.
What are the official names of this protein?
Probable NADH oxidase, NOXase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.
Protein: AROK_ALKOO
Sequence: MVKNIVLVGFMAVGKTTLGKLLADQLDYNFIDLDLFIEKKESMSISEIFRLKGEAYFRQKESEALDLLSDVEQSVIATGGGTVISEENRSKLKQIGRVIYLEAEPSWILTNIKRSAVIRPLLVDERKSMDKIIEILENRRLYYEGTSEIKIPVSHRTLEEIIKDIVCNI
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_TOLAT
Sequence: MLYSVLAISLGASAGAVSRWLLGLGFNTLFPTIPPGTLLANLLGGYLIGIAVTFFAANPNLPPEWRLLVITGFLGGLTTFSTFSAEVTTLLQQGRLLWAGGAIAVHVIGSLVMTLLGMATMSLLQRS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RDRP_I68A4
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: FENR_STRPD
Sequence: MKDKAYDITIIGGGPIGLFAAFYAGLRGVTVKIIESLSELGGQPAILYPEKMIYDIPAYPSLTGAELTENLIKQLSRFEDRTTICLKEEVLTFDKVKGGFSIRTNKAEHFSKAIIIACGNGAFAPRTLGLESEENFADHNLFYNVHQLDQFAGQKVVICGGGDSAVDWALALEDIAESVTVVHRRDAFRAHEHSVELLKASTVNLLTPYVPKALKGIGNLAEKLVIQKVKEDEVLELELDSLIVSFGFSTSNKNLKNWNLDYKRSSITVSPLFQTSQEGIFAIGDAAAYKGKVDLIATGFGEAPTAVNQAINYIYPDRDNRVVHSTSLID
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: HSLV_SHEB9
Sequence: MTTIVSVRRNNQVVIAGDGQVSLGNTVMKGNAKKVRRLYHNKVLAGFAGGTADAFTLFERFEAKLEMHQGHLLRSAVELAKDWRTDRMLRKLEALLVVADAETSLIITGNGDVVQPEHDLVAIGSGGNYAQAAALALLQNTELSALEIAEKSLTIAADICVFTNQFKTIEELNY
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_YERPN
Sequence: MSNRKYFGTDGIRGKVGESPITPDFVLKLGWAAGKVLARHGSRKIIIGKDTRISGYMLESALEAGLAAAGLSALFTGPMPTPAVAYLTRTFRAEAGIVISASHNPFYDNGIKFFSIDGTKLPDDVEEAIEAEMEKPLTCVESAELGKANRIVDAAGRYIEFCKGTFPSELSLNELKIVVDCANGATYHIAPSVLRELGATVITIGCEPDGMNINEECGATDVRLLQERVLAEGAHVGLAFDGDGDRLMMVDHLGNKVDGDQILYIIAREGLRQGQLKGGAVGTLMSNMGLQLALKDLGIPFVRAKVGDRYVLEAMQEKGWRIGAENSGHVILLDKTTTGDGIVAGLQVLTAMVRNHMSLHDLCSGMKLLPQILVNVRFSGEHNPLKSDEVEEVTRQVEKELGGRGRVLLRKSGTEPLIRVMVEGDAEESLIAEMANRIADAVKAAG
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: HRCA_MYCLE
Sequence: MGNADERRFEVLRAIVADFVATKEPIGSRALVERHNLGVSSATIRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLEDVKPLSAAERRAIQSFLESGVDLDDVLRRAVRLLAQLTCQVAVVQYPTLSTSTVRHLEVIALSPARLLMVVITESGRVDQRIAELGDVIDDYQLSQLREMLSQAMGGKKLSAASAAVADLVGRFRGTGGLANAVGRSANVLLESLVEHTEERLLLGGTANLTRNSADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETAAEQIMGTSMVSTAYGTSGTVYGGMGVLGPTRMDYPGTIASVAAVALYIGEVLGAR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: REV_HV1Z2
Sequence: MAGRSGDRDEDLLKAVRLIKILYQSNPPPSPEGTRQARRNRRRRWRARQRQIHSIGERILSTYLGRSEEPVPLQLPPLERLNLNCSEDCGASGTQGVGSPQISVESPTVLESGTEEQC
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: IXTPA_PHOLL
Sequence: MQKVVLATGNPGKVRELAQLLADFGLDIVAQTELGVDSAEETGLTFIENAILKARHAAQVTGLPAIADDSGLSVDILGGAPGIYSARYAGENATDQQNLEKLLDTMKDIPDDQRQAQFNCVLVYIRHAEDPTPLVFHGRWPGFIAHKSAGNGGFGYDPIFYIPELGCTAAELTGEQKNAVSHRGQALKMMLDTLRNA
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: RS19_LEGPC
Sequence: MARSIRKGPFIDHHLISKVEAAIESKSKKPIKTWSRRSTIVPEMIDLTIAVHNGKDHVPVFITDNMVGHKLGEFAMTRTFKGHSGDRKAKGK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.