PharMolix/UniProtQA huggingface dataset:
Protein: UMOB_PROMI
Sequence: MRLSVIILAIFMISLFIMAAFLFFKRRRLDGSYHLPSLAKPTYRKLTQDDYGVISDYLSYFGTSKFSAGYSLQNFPEIPTKGEVVTTLRNIVNRFAGSSEGINHWRYYIDAVEIHIPPLLVPYLQQENVLDVVCTPSIPIVIGVNGHFLKDEKSHFSALSLKQLSEPILSNGTSTIQKNEGDAAHLLHIRQETNEEYRLHHSSGFWNGSLICLGLILWLTALMMPQVFLPWIMAAGGTFLVLGLFLIYRPIIKSRKQEVHCFKGRLKRWGLFGNFDHGQVKNISLGGIDLVYPPHWEPYIQNDIDKVTYLEMYPNHHVIKQGPYLSLHDEEKNYPYKRYIKNIIFVVCSLFIIGMLYLYQPLSLSMKLTFSWIKESEPHLVTNFTELETAKLHVGDIIQAKGVGMCYMPPNLSSKNNKTIFAPFDCSGIYWNNSNPMPMPESSTIEKAAALLYLVEEQLHPVSNNRVNPSLGQAITKSGMNLLDNFDGIILKTQDLCPRENECIRLKMALVNLSNVNDWPSLVQRAESGKLTGTNVLLRAVSAEALEKLVDTTTSSFIYREIDKAAILLNSPPPGGVLLISDERKQLVDYASNTNSVFEPTPLEQWRELQRLSDILLHTPFNTGGVITGMVIDANGTLQIFLHSMPDSMTLLYYIGNTLLLFFAIGFLILNLFFIIRRRRQNNQRMHKISQYYEHCFYRPPQ
What is the function of this protein?
Up-regulator of flagellar flhDC master operon.
What are the official names of this protein?
Flagellar operon control protein UmoB.
What is the protein family that this protein belongs to?
Belongs to the IgaA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NIFH_CHLL2
Sequence: MRKVAIYGKGGIGKSTTTQNTVAGLAEMGKKVMVVGCDPKADSTRLLLGGLQQKTVLDTLREEGEEVELEDIIKEGYRNTRCTESGGPEPGVGCAGRGIITSVNLLEQLGAYDEEWDLDYVFYDVLGDVVCGGFAMPIRDGKAEEIYIVCSGEMMAMYAANNICKGILKYADAGGVRLGGLICNSRKVDNEREMIEELAKKIGTQMIHFVPRDNFVQRAEINRKTVIDYDPTHGQADEYRALARKIDENEMFVIPKPLEIEELESLLIEFGIAN
What is the function of this protein?
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
What are the official names of this protein?
Nitrogenase iron protein, Nitrogenase Fe protein, Nitrogenase component II, Nitrogenase reductase.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: PIMT_SHEPC
Sequence: MTRVALTSAVNLAKKLSDAGIRNQAVLKAISQTPREMFLDNALAHKAYENTALPIGQGQTISQPYIVARMTELLLSNMPKKVLEVGTGSGYQAAILAQLVPELCTIERIKGLQIQARQRLKRLDLHNVSFKYGDGWQGWSNRSPFDAIMVTAAAATVPEALLSQLVDGGVLVLPVGENTQQLMRITRHRERFSSENIETVKFVPLVNGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_RALSO
Sequence: MSTVVATVVFAVAAYLIGSVSFAVVVSRAMGLADPRTYGSGNPGATNVLRSGNKKAAILTLLGDAAKGWLAVWLAQLLAPRYGVEDMGIALVVIAAFLGHLYPVFHRFTGGKGVATAAGILLALSGWLGLATLATWLIIATFFRYSSLAALVSAVFAPFYYVLLFGIDPLAGAIAVMSVLLIARHRANIAKLLAGKESRIGEKKKPT
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLNR_BACSU
Sequence: MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEGNRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSDDELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH
What is the function of this protein?
Transcription repressor that represses many genes including ureABC and tnrA, during nitrogen excess (PubMed:2573733, PubMed:1677938, PubMed:10231480, PubMed:18331450).  On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site (PubMed:10231480, PubMed:25691471).
What are the official names of this protein?
HTH-type transcriptional regulator GlnR.
Protein: MRS2_YARLI
Sequence: MDEEEHKDHQEEEDPHHFAFSDNYSEAVLGGEISATVFDVTGKVVHVAHKMTKYEFLLEHGLYPRDLRNIDPSPVSIIPSILARGRKGAGRCILVNLLHIKALILHDKVLIFDTHSKNKSDTHRLGMFLYELENKLKPTINPEKMHTDMTVLPFELRVLEAILVNVMTTLDGELQVHLKTLNEILVGLEDHVDREQLKELLIGNKNVSRFYQKAVLIRDVLEELLESDDDLQQLYLGTHPKEGLAEVELLIESYCKQADEIVQQASNVRSHIRSTEEIVNIIVDANRNALMLLELKVTIVTVGFAVGAFVAALYGMNLENFIEETNEGMVLVVGVACLGGLLVTWFNLTKLHKTQKIAMFSNAATHTASKPYMLQWIIGLLRRKRTKSRFDNIDMSRPKMKGKKSNILHQLTKMTGKRR
What is the function of this protein?
High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix.  Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.  It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
What are the official names of this protein?
Mitochondrial inner membrane magnesium transporter MRS2, RNA-splicing protein MRS2.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TIG_LEUCK
Sequence: MSNWTPAADQKNQGTLEFEISRAQVEEGLEKAFQRNKNQVSIPGFRKGKVTKALFFSKFGEEALYQEAMDIVLPAAYEAAVEEAGITPVGRPNIEPVSMNKGEAWTLKAEVTTAPAIKLGEYLNLEVAAEDTAVSDADVDAEIKRLQDGQAELVLQEESVKAEDGDTVVIDFDGSVDGDHFDGGQANDFSLALGSGQFIPGFEEQLVGHTAGEDVEVKVTFPEDYQAADLAGKEALFEVKIHELKRKELPELDDEFAKDVDEEVETLAELKEKTAKKLADDKEAAAKSAFEDAVITKAVDNASVDGDAIPDAMIEEDVHRQVDQYLGQLQQQGISREMFFQISGQTEEDLHKQFEEGAATRVKTNLVLEAIVKAEGIEPSAEQVTEEINNLATQYNMDAEQVRSSLSDSLLKHDIAMREVIKKITDSAKAK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PROA_ERYLH
Sequence: MNDQTLDPAIHIQQLGTAARDAARGLVSASTEAKNKALMEAARALREATPALLEANARDVASVEGKKDEAFIDRLKLDEARVEGMASALEQIAELPDPVGRVLAQFDRPNGLRIERVAVPIGVIGMIYESRPNVGADASALCLKSGNAVILRGGSESRHSTREIVACMQAGLKAAGLPENAVQTVQTTDRNAVAELLKADEHVDLVIPRGGRGLVELVRDQASVPTLLHLDGNCHSYVHEAADVAKAVDVVRNAKLRRTGICGATESVVVDRVIAPALILALADAMAGDCELRGDETAVQLDDRITPASEDDWNTEYLGPIASVKVVDGLDEAIEWVEGHSSHHTDAILTEDAEAARRFMTAIDSAIVMHNASTQFADGGEFGMGAEIGIATGKMHARGPVGLEQLTSFKYLVHGSGQTRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_ECOLU
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNVAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SESD1_XENTR
Sequence: MDATVILPILKKKLAFLSGGKDRRSGLILTIPLCSDQTSMDELSVTLDYLLSIPSDKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSGNKLTRYIEPNQLTEEFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELAVINNGSDKGSQNEKERSVDFNYLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLDEIQQKVMQVVNWLEGPGSEQLRTQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKTLQQRLSDVCYRQASQLEFRQNLLQTALDFHSVAQDLSQQLDGLLGMLCVDVAPTDGAAIQQTLKLLEEKLKSVDTGLQGLREKGQGLLDQITNQASWAYGKDVSTENKDNVDHIQGIMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVDWLNELLDALLKTHIRLGDDSQETKILLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPKLNRVWKQFTITSEERVHRLEMALAFHSNAEKILQECPDLGETVMDFEQFDEVEAVGKSVLDRLTVPVIYPDGTEQYFGTPSDMASTAEHIRERIKMVCLKKQQLLEPDESIRES
What is the function of this protein?
May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels trpc4 and trpc5.  Binds phospholipids (By similarity).
What are the official names of this protein?
SEC14 domain and spectrin repeat-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOLO family.
Protein: AC4CH_SALCH
Sequence: MQPNDITFFQRFQNDILAGRKTITIRDASESHFKAGDVLRVGRFEDDGYFCTIEVTGTSTVTLDTLNEKHAQQENMSLDELKRVIAEIYPNQTQFYVIDFKCL
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: EXPL5_DICDI
Sequence: MRINFKLILIILTSFYGIINCQSTCPYSKTVINGASATFYSAMDNGNCGFGKLTGPTGPGNYMIAALGTKLYQNGAQCGQCFKISNSKNASVTVMATDSCNDAGYCQRDNHFDLSPTAFSILGAQSQGVLDGLSYVKVPCRVSGNVKVMLKDGSNAYWTSFLVFNNAIDVKQVSIKLSGSSTYVPLTQTTYNYWPSSITAGSFQVRIESIGGEFIYVTIPSVVSSKIYDTGSQFSSSC
What is the function of this protein?
May serve to lubricate the movement of the cellulose microfibrils during cell growth and wall extension and/or may serve to maintain the fluid state of the slug cell wall.
What are the official names of this protein?
Expansin-like protein 5, Ddexpl5.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPC_RHORT
Sequence: MSDILREICDTTRAEVARRKAALPLADVTARAEDANAPRGFANALTRTADSGRPALIAEIKKASPSAGLIRPDFNPAVLARAYHAAGATCLSVLTDGPYFQGHADFLIAARAAVPLPVLRKDFMVDPWQVVEARAMGADCILVILAALDDGAAAEIEACAHDWGMDVLAEVHNEEECARALTCLTTPLLGVNNRNLKTLVTDLAVTERLAKMVPADRVLVAESGLRTRKDLDRMTAVGARRFLIGEHFMRQPDVGDAVRALIG
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: GCST_STAAM
Sequence: MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNLTTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQLVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLHGQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSPSSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: NDHM_PAUCH
Sequence: MANTILKSTTRHIRIFTARVENNDLIADTSQLTLDIDPDNEFLWEQSTIEKIQSRFKELVECHTGADLTDYTLRRIGTELEGTLFSLLQAGELSYNPNARVLNYSMGLPRTTELS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit M, organellar chromatophore, NAD(P)H dehydrogenase I subunit M, NDH-1 subunit M, NDH-M.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhM subunit family.
What are the subcellular locations of this protein?
Plastid, organellar chromatophore thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GET3_PARBP
Sequence: MSSAAMVKAEDSLEPTLQNLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFTNLSAMEIDPNGSIQDLLAAGGGQGDDSMGGLGIGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVLEKALAKLAQLSTQFGPMLNSILGGRGGLPGGQNLDEILSKMESLRETIAEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYHIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEELYEDFNVVRMPMLVEEVRGKEKLEKFSDMLIHPYVPPQE
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: ATPD_STUS1
Sequence: MINTQTLARPYAKAAFEFASAAGQTDSWSKMLNLAAVAVEVPEVAALLNDPRLTSESKVQALVRVLGDDADEAFRNYVQTLGENDRLSVLPTVWELYEDIKAQAEKTLEAEVETAFELSNAQLQTLAAALSKRLDRTVNLQQVVNPALIGGVLIRAGDVVVDGSVRGKLSQLAESLKS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
Protein: DAPAT_BACFR
Sequence: MALVNEHFLKLPGSYLFSDIAKKVNTFKITHPKRDIIRLGIGDVTRPLPKACIEAMHKAVEEMTSAETFRGYGPEQGYDFLIEAIIKNDYAPRGIHLSPTEVFVNDGAKSDTGNIGDILRHDNSVGVTDPIYPVYIDSNVMCGRAGVLDTESGKWSNVTYMPCTAENHFIPAIPEKRIDIVYLCYPNNPTGTTLTKAELKKWVDYALANDTLILFDAAYEAYIREPDIPHSIYEIKGAKKCAIEFRSFSKTAGFTGVRCGYTVVPKELTAATLEGERIPLNRLWNRRQCTKFNGTSYITQRAAEAIYTPEGKEQIQETINYYMTNARIMKEGLESTGLKVYGGVNAPYLWVKTPNGTSSWRFFDQMLYEANVVGTPGVGFGPSGEGYIRLTAFGERDDCIEAMRRIKNRL
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: PLSY_YERPY
Sequence: MSAIALGMIIFAYLCGSISSAILVCRVARLPDPRTHGSGNPGATNVLRIGGRTAAVAVLLFDILKGMLPVWIAYLLHIPPLYLGLTAIAACLGHIYPVFFHFKGGKGVATAFGAIAPIGWDLTGLMTGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVAMLSCLILMRHHDNIQRLWRGKEGKIWDKLRKKKQKTPAEEAAELEEKED
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TIG_SHELP
Sequence: MQVSVETTQGLERRLTISVPAEQIEKAVSDSLKNEAKRARIPGFRPGKVPVSVINKRYGKAIRQEITGEVMQRNFIEAIIAEKLNPAGAPTFVPGETDAENFQFVATFEIYPEVELKGLDAIEVEQPTAEVTDADVDAMIETLRKQHATFEAVEREAAEGDKAKIDFVGSIDGEEFEGGKAEDFELQLGSGRMIPGFESGVEGHKAGEAFDIDVTFPEDYHAENLKGKVAKFAITLKEVQAANLPEVNDEFAKLFGVADGGLEALKVEIRKNMSRELEQALKANVKDQVLNGLLEQNEIELPKALIDGEVNVLRQQAMQRFGNQAANMPELPADLFTEQAERRVKVGLLLGEVIKTNELKADDERVQALIASMASAYEDPQEVIEYYNNNQEMMQNMRNVALEEQAVEALLKTAKVTEKAVQFEEFMNKATGRA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: SH3B4_HUMAN
Sequence: MAAQRIRAANSNGLPRCKSEGTLIDLSEGFSETSFNDIKVPSPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELELLGGWTDDKKVPGRMYSNNPFWNGVQTNPFLNGNVPVMPSLDELNPKSTVDLLLFDAGTSSFTESSSATTNSTGNIFDELPVTNGLHAEPPVRRDNPFFRSKRSYSLSELSVLQAKSDAPTSSSFFTGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPDTSISIHVPEGHVAPGETQQISMKALLDPPLELNSDRSCSISPVLEVKLSNLEVKTSIILEMKVSAEIKNDLFSKSTVGLQCLRSDSKEGPYVSVPLNCSCGDTVQAQLHNLEPCMYVAVVAHGPSILYPSTVWDFINKKVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPNPAPVALQLWGKHQFVLSRPQDLKVCMFSNMTNYEVKASEQAKVVRGFQLKLGKVSRLIFPITSQNPNELSDFTLRVQVKDDQEAILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFATTTKYPTFQDRPVSSLKFGKLLKTVVRQNKNHYLLEYKKGDGIALLSEERVRLRGQLWTKEWYIGYYQGRVGLVHTKNVLVVGRARPSLCSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRSFADALGYVNLPLTFFCRAELDSEPERVASVLEKLKEDCNNTENKERKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHLGLDKMKNPITKRWKHLTGTLILVNSLDVLRAAAFSPADQDDFVI
What is the function of this protein?
May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.  Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes.  Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation.  Thereby, may indirectly regulate cell growth, proliferation and autophagy.
What are the official names of this protein?
SH3 domain-binding protein 4, EH-binding protein 10, Transferrin receptor-trafficking protein.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
Protein: VIAA_CROS8
Sequence: MLTADSLNLILAISEGELVEEIVIALLASPQLAVFFEKFPRLKHALTQDIPRWREQLKTRLKEAHVPPELEEEVIGYQKSQLLSTSQFIVQLPQISALLRRVGSPFADQAQRLIADNPHFTPALHTLFLQRWRLSLVVQATSFNQQLLEEEREQLLSEVQERMTLSGQLEQVLVENEDSAGRLWDMSDGKLRRGDYQLIVKYGDFLADQPELMQLAEQLGRSREAKSVPKKEAPLETFRTLVREPASVPEQVDGLQRSDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLQGDAWREKVMQRPVTRQDYDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRIALADNRRCFIMLFSSEVVRYELCGRDGIEQAIRFLSQRFRGGTDLASCFRAIAEKLQGGEWFDADAVVVSDFIAQRLPDEVVNKVKELQRVHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLVRRLRR
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.
Protein: PHNC_BURMA
Sequence: MDAIRIERLSKTFPNGRKGLEDIDLAIAPGEMVALIGASGSGKSTLLRQIASFSSSDARPSRIDIFGRSIQRDGRIARDVRRMRRDIGFVFQQFNLVNRLSVETNVLIGALARVPMWRRLAGRFSRADRALAAQALGEVGIAEHARERAANLSGGQQQRAALARALVQRARIILADEPIASLDPAASRRVMEMLRALNANHRLTVLVSLHQIDVALRFCPRVVALRAGRIVYDGPSAALTRERLHALYGDDAHLPFAVGDEVRPAAREAAGEPARRAPTAFDSAGSPDLPDSQPASPRRMLAASSMR
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RIBB_SHEFN
Sequence: MNQLSLLAEFGEPITRVENALAALREGRGVLLLDDEDRENEGDIIYSVEHLTTAQMALMIRECSGIVCLCLTDEHANKLQLPPMVINNNSANQTAFTISIEAKHGVTTGVSAQDRVTTIKTAANRDAKASDLAHPGHVFPLRARAGGVMSRRGHTEGTVDLMQMAGLMPAGVLCELANEDGSMAKTPEIIAFGLKHNMPVLTIEDMVMYRNQYDLKLA
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: IKBL_ASFK5
Sequence: MDTVGLFSAEVEHLFIEWIKKHIKKGDLTLFERFFKADPWIVNRCDRSKITVFMWICIYGRLDFLRFLFKQESYPGEIISHYRRDKDGNSVWHYLAEKKNHLLLEEVLEYFGKIGIKVCFRNFNGITPVMKAAMRGRTLSVLSLIKYGANPNQKDYLKGFNTWDWAVFTGHADLVKSLNKDYQKPLFMHFPLYKLDVFHRRHKKKPKIIITSCEDNVYEKLPEQNPNFLCVKKLNKYGK
What is the function of this protein?
IkB-like protein that inhibits the binding of NF-kappa-B to DNA, thereby downregulating pro-inflammatory cytokine production (By similarity).  Forms a heterodimer with the NF-kappa-B subunit RELA/p65 and prevents the activation of the NF-kappa-B transcription factor (By similarity).  Inhibits calcineurin function, which is required for the induction of nuclear factor of activated T cells (NFAT)-dependent immune response genes.  Prevents the binding of substrates to calcineurin without affecting the phosphatase activity (By similarity).  Does not contain the serine residues that are phosphorylated by host IkB kinase and thus is not degraded following stimulation of the NFkB pathway (By similarity).
What are the official names of this protein?
IkB-like protein, Ankyrin repeat domain-containing protein A238L, p28.
What is the protein family that this protein belongs to?
Belongs to the asfivirus A238L family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Binding to host PPP3CA/Calcineurin may mask the second nuclear localization signal thereby contributing to the cytoplasmic retention of A238L.
Protein: PSA_METKA
Sequence: MAVQPAQTAYDRAITVFSPDGRLFQVEYAREAVKRGTTALGIKVEEGVVLGVDKRVTSKLIEPESIEKVYQIDTHIGAATAGLVADARVLVERARIEAQTYRYTYGEPIDVDVLVKAICDLKQVYTQHGGVRPFGTALLIAGVDTKGCRLFETDPSGALTEHKATAIGEGRQEALDVFEEEYREDMTLQEAIELAVRALYEASREETTADNLEIAVVDKQGFRKLERKKIEEMFERVVGSEEDEGE
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PsmA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.