PharMolix/UniProtQA huggingface dataset:
Protein: RK6_CYAPA
Sequence: MSRIGKRLINIPSQVTVSIKDQVFSVKGPKGELSKQIPYGIQVVQQNDHLVVERVAESLLARKLHGLCRTLVSNLVQGVFQGFERRLEIQGVGYRAQMDGKKLVLNIGFSHPVVIEPPTEIQLQVENNTNIIIKGIDKELVGKLAAEIRAVRPPEPYKGKGIRYLGENVKRKVGKAGKK
What is the function of this protein?
Binds 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L6, cyanelle.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: PSB4_PICGU
Sequence: MDIVLGIRVEDCTLVATSKAATRGISVLKDTDDKTRQLNSHNLMAYSGEAGDTVQFAEYIQANTQLYTMRENDTELSPKATASFVRNQLATSIRSRKPYQVNVLLAGYDTNTGKPSLNWIDYLGTQVELPYAAHGYAGFYCTSLLDKHYKKGMNFEDGLDLLKKCIKELETRMPIDFKGCYIKVVDKEGIKLVE
What is the function of this protein?
Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity (By similarity).
What are the official names of this protein?
Probable proteasome subunit beta type-4.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: APT_MYCSJ
Sequence: MTDISKVIASLMREVPDFPEPGIQFKDLTPLLADAEGLMAVTDALAATAEGADLVAGIDARGFLLGAAVALRLGTGVLAVRKGGKLPPPVHSQTYNLEYGSATLEIPADGLDIAGRSVVIIDDVLATGGTVAATHRLLTSGGATVLHAAVVLELTALGGREVVQPLSVSSLYTV
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_STRP1
Sequence: MRIADYSVTKAVLDRHGFTFKKSFGQNFLTDTNILQKIVDTAEIDQNVNVIEIGPGIGALTEFLAENAAEVMAFEIDDRLVPILADTLRDFDNVQVVNQDILKADLQTQIKQFKNPDLPIKVVANLPYYITTPILMHLIESKIPFQEFVVMMQREVADRISAEPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRDQPLIEVKDEDFFFRVSRLSFVHRRKTLWNNLTSHFGKSEDIKAKLEKGLALADIKPSIRGEALSIQDFGKLADALKEVGL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB2_PHYPO
Sequence: MREIVHVQVGQCGNQVGAKFWEVVSEEHGIDSAGTYKGDTDLQLERINVYYNEVAGSKYVPRAVLVDLEPGVLDSIRASSIGSMFRPDNFTHAQSGAGNNWAKGHYTEGAELVESVVDVVRKEAENCDCLQGFQICHSLGGGTGSGLGTLLISKIREEFPDRMMCTFSVMPSPKVSDTVVEPYNATLSIHQLVENADEVMCIDNEALYDICFRTLKLTTPTYGDLNHLVSGVMSGITACLRFPGQLNSDLRKLAVNLIPFPRLHFFLIGYAPLTARSAMGFRALTVPELTQQIFDSRNMMAASDPRHGRYLTASATFRGKMSTKEVDEQMHAVQTKNSSFFVEWIPNNIKSSVCDIPPKGMKMSATFIGNNTCIQELFKRIGLQFSAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEASVDDEAMEDDAEAEGGAGQNEAVEEF
What is the function of this protein?
This is the major beta tubulin of mitotic spindle.
What are the official names of this protein?
Tubulin beta-2 chain, Tubulin beta-major chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Mitosis in the slime mold Plasmodium differs from the process in many eukaryotes. The tubulin chains must be transported to the nuclei for intranuclear assembly of the spindle.
Protein: STR16_ARATH
Sequence: MAEESRVPSSVSVTVAHDLLLAGHRYLDVRTPEEFSQGHACGAINVPYMNRGASGMSKNPDFLEQVSSHFGQSDNIIVGCQSGGRSIKATTDLLHAGFTGVKDIVGGYSAWAKNGLPTKA
What is the function of this protein?
Thought to act during the early stages of leaf senescence.  Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds.  Substrate preference is thiosulfate > 3-mercaptopyruvate.
What are the official names of this protein?
Thiosulfate sulfurtransferase 16, chloroplastic, Rhodanese, Senescence-associated protein, Sulfurtransferase 16, AtStr16.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HIS1_METBU
Sequence: MIRIAIPNKGRLHEPTIQMFKEAGLPVLGGSNRKLFAKTNDPEITFLFARAADIPEYVQDGAADVGITGLDLISETESDVEMLLDLKYGGADLVLAVPEESDISSANDLDGMRVATEFPGITARYFKDLGIKIDVVKVSGACEMTPHVGIADAIVDISSSGTTLVMNHLKVIEKVFSSSIYLIANHETAKTEEKIEHIKTALESVMHAKAKRYLMMNAPITVVDDLKEVLPGLAGPTIMKVESKEDIVAVHAVVDADIIFATITKLKAAGAFDILVMPIERMIP
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCOR_CRIGR
Sequence: MNSFNKDEFDCHILDEGFTAKDILDQKINEVSSDDKDAFYVADLGDVLKKHLRWLKALPVTPFYAVKCNDSRALVNTLAAITVDCASKTEIQLVQGLGVPPERVIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKVTKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQALSDARCVFDMGTEVGFSMYLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPPDSGVRVIAEPGRYYVASAFTLAVNIIAKKIVSKGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLPKRPKPDEKYYSSSIWGPTCDGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPSIYYVMSRPMWQLMKQIQNHGFPPEVEEQDVGTLPISCAQESGMDRHPAACASASINV
What is the function of this protein?
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.  Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
What are the official names of this protein?
Ornithine decarboxylase, ODC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Protein: DKC1_HUMAN
Sequence: MADAEVIILPKKHKKKKERKSLPEEDVAEIQHAEEFLIKPESKVAKLDTSQWPLLLKNFDKLNVRTTHYTPLACGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGVLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKLMIKQGLLDKHGKPTDSTPATWKQEYVDYSESAKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAGLESGAEPGDGDSDTTKKKKKKKKAKEVELVSE
What is the function of this protein?
Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression.
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit DKC1, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies). SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Protein: ARP1_SCHPO
Sequence: MTVTEIFDNQPICIDNGSGFIKAGFAGDDIPKCLFPTCVGRIKHERVMPSSIQKDMFVGSEAQNLRGLLKIQRPIERGIIQNWSDMEEIWSYIYSDQQLNTLPEEHPLLLTEPPLANIRNKEKIAEYFYETLNVPALSFSLQPVLALYASARTTGIVLECGDGLTHSVPIYDGFSIPSAIQQEEIGGRDVTDYLQLQLRKSGHELVSSAEKEIVREIKEKCCYVASDFRSEIESWTEHKPQIHTYQLPDNQTITLGTECFSAPEVLFNPEMMGSEASGLHIQLFKSILLSDIDLRSTLYSNIVLSGGSTLLRGFGERFISELRAISGKKNQVKIYASPERMHNAWLGGSILASLSTFRRLLITSEEYKNDQNVIFRRRF
What is the function of this protein?
Core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding.  The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint.  Arp1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits.  Required for proper orientation of the mitotic spindle (By similarity).
What are the official names of this protein?
Centractin, Actin-like protein, Actin-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RLA2B_MAIZE
Sequence: MKVIAAYLLAVLGGNTSPTADDVKSILESVGAEADEEKLEFLLTELKDKDITEVIAAGRERLSSVPSGGGAIDMGAPAAVAGGGAAPAEEAKKEEKVEEKEESDEDMGFSLFD
What is the function of this protein?
Plays an important role in the elongation step of protein synthesis.
What are the official names of this protein?
60S acidic ribosomal protein P2B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Protein: KU80_NEUCR
Sequence: MADKEATVYVIDLGESMADCHNGRNESDLEFGMRYIWDKITTTVAASRKTWNVGVVGLNTDETNNNENREEYQGYENISVLQELGPMTMASLRALKSKIEPSSTSSADAISAIVVALRMIQTFTKKLKYKRKIIVVTNGESPIDDDQSEEVANMLNDVGIELIVLGVDFDDAEYGFKEEDKPRHKEQNEKILKTLVDHCESGAFGTMAQAVEELATPRIKSVRPFKAYDGPLTLGDPQKYPSALSIQVERYFKTKRATPPSASNVANPNGPPQTQVWNEDDGVPFSGVGLQPVKQLRTYRIEDSKAAGGKKDVDMEDLAKAYQYGRTVVPFGKSEEDYLKYETTKSFTIIGFVPMSSYEPFLNMGETGLIVAQKVNEEAELGLSALIHALHELESYAVARYVNKDKAPPQILLLKPNPAIEDDIECLYDIPLPFAEDVRSYQFPPLDKVLTITGNVLTEHRLLPNNDLQQAMSDYVDAMDLTEYGQDDDGHPAEYAPIDDLYNPVIHHMNQAIRNRAVNPDAPLPPVAEILTRFTHPPEPLLAKAKTEIDGLIQAAEVKKVPPKVQGKRGRKDTVKPLSGLDIDALLSETRPRTKKTPIISTENAIPEFKQILETAEDDETIEIAAKQMGNIICKLVSDSFADVLYPRAAENLRVMREELINMEVPTLYNKYITKLKESLLSGNLNGDRREMWFRWIVGGRLGLITQDESEVSEVSENEAKAFLK
What is the function of this protein?
Single-stranded DNA-dependent ATP-dependent helicase.  Involved in non-homologous end joining (NHEJ) DNA double strand break repair.  DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA.  Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection.  Required also for telomere recombination to repair telomeric ends in the absence of telomerase.  ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase.  Involved in telomere maintenance.  Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement.  Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere.  Required for mating-type switching (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase II subunit 2, ATP-dependent DNA helicase II subunit Ku80, Protein mus-52.
What is the protein family that this protein belongs to?
Belongs to the ku80 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: ACCD_STRR6
Sequence: MALFSKKDKYIRINPNRSVREKPQAKPEVPDELFSQCPGCKHTIYQKDLGSERICPHCSYTFRISAQERLALTIDMGTFKELFTGIESKDPLHFPGYQKKLASMREKTGLHEAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITRLFEYATVEKLPVVLFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFYLTILTDPTTGGVTASFAMEGDIILAEPQSLVGFAGRRVIENTVRESLPEDFQKAEFLLEHGFVDAIVKRRDLPDTIASLVRLHGGSPR
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1070_METJA
Sequence: MRKYLIILVLLLFLSSSFGYYFDYIKVSESNPIKTITFKINKAENYSYKLSFVHYGNINKSMKVNIYLNGNLAYTIDDSNDASPAYKKNASIDITNYLKDGENVLKVEGMNLIGNENYHPYYVLKDIYINEPAKTPIDFKLMIYALLIICFLIYKKC
What are the official names of this protein?
Uncharacterized protein MJ1070.
Protein: TAL_BACVZ
Sequence: MLFFIDTANIDEIKEAYELGVLAGVTTNPSLVAKEADVSFHDRLREITEVVSGSVSAEVISLNAEEMIEEGKELAKIAPNITVKIPMTSEGLKAVKALSDLNIKTNVTLIFSANQALLAARAGATYVSPFLGRLDDIGHNGLELISEIRQIFDIHDIDTQIIAASIRHAQHVTEAALRGAHIGTMPLKVIHQLAKHPLTDKGIEQFLADWNK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_ACTP7
Sequence: MTIEVQENREPKIIEVTEIMKMLPHRYPFLLVDRVIDFEEGKWLKAIKNVTVNEPCFTGHFPESPIFPGVLILEAMAQATGVLAVATHGKMAQDELYYFAAIDNARFKRPVVPGDQLTFEVEFLKEMRGITKFTGKAFVDGKLVCEADLMCARK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCFE_DICDI
Sequence: MENKKESSLLYILTGATSGLLADSIMHPVDTVRARVQIEKVGKSQYKGTFNALNQIIKNEGVSYLYKGFPIVATATVPAHALYFLGYEYSKQWVTDRYGKKWGESTITHFSAGFVADALGSLIWVPMDIIKQRLQVQTNTQKLNPNQTYYKGSFHAGKIILQEEGIRGLYRGFMPALATYGPFVGIYFSVYEKCKSTISSLLSKEKDQYLPIPYQLGSGFFAGAFAAAVTCPLDVIKTRIQVQRSTEKQIYKGMWDSFKTILKEEGPKAFVKGMGARIWWIAPGNALTIASYEQLKYLFKDLI
What is the function of this protein?
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.
What are the official names of this protein?
Mitochondrial substrate carrier family protein E.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: IMP4_YEAST
Sequence: MLRRQARERREYLYRKAQELQDSQLQQKRQIIKQALAQGKPLPKELAEDESLQKDFRYDQSLKESEEADDLQVDDEYAATSGIMDPRIIVTTSRDPSTRLSQFAKEIKLLFPNAVRLNRGNYVMPNLVDACKKSGTTDLVVLHEHRGVPTSLTISHFPHGPTAQFSLHNVVMRHDIINAGNQSEVNPHLIFDNFTTALGKRVVCILKHLFNAGPKKDSERVITFANRGDFISVRQHVYVRTREGVEIAEVGPRFEMRLFELRLGTLENKDADVEWQLRRFIRTANKKDYL
What is the function of this protein?
Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.
What are the official names of this protein?
U3 small nucleolar ribonucleoprotein protein IMP4, U3 snoRNP protein IMP4, Interacting with MPP10 protein 4.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TCPA_CLAP2
Sequence: MATVGTEEKNPIGSASNTAEPNVTEPQKQYASGFKLTIIVISLCLSLFLCGLDQTIITTAVPIITNDFKAIEDVGWYTTAYLLTTSSFQIAYGKLYTTLSVKMILLMALAIFELGSIICAAAPNSTTLIVGRAIAGLGAAGIFPGSTLVLVHAAPMERRPALLGITTGMFGIASLCGPFIGGAFADGASWRWCFIINVPLGVITAVIVTFFVFTPVDPLYAEWTFKDKLAYAKIPEILVLVAALVCLVLGLQWGGTTYAWSDGRIIALLVVFAVLTTAFLVLQVLLPKSRTIPTSIVKNRNIWFASIFALCSSGAMFIAVTYLPIYFQAIKNASALSSGVNVMPLILGFLVMSIISGVITNTTGYYNPSMFLCTILASVGAGLVSTFDVGTPQPKWIGYQALLGFGIGFGLQQPIVCAQHVLDERDVPFGVAFINMMQMLGGAIFVAVSQNVFLNGLANGIAEALPGFNTHKIIEGGLTDFKNLFTSDQLPKAIPVYAHVLGQVFLIATGLCVGTLLGSLGVQWRSVKKAKVTEDQADVERK
What is the function of this protein?
MFS efflux transporter probably involved in thioclapurine export (PubMed:27390873).
What are the official names of this protein?
MFS thioclapurine efflux transporter tcpA, Thioclapurine biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VE2_HPV47
Sequence: MENLSERFNALQEQLMNIYEAAEQTLKAQILHWQTLRKEAVTLYFARQKGINRLGYQPVPALAISEARAKEAIYMVLQLESLQKSAFALEPWTLVDTSTETFKSAPENHFKKGPVPVEVIYDKDEANANLYTMWTFVYYMDSDDVWHKTTSGVNQTGIYYLYGTFKHYYVLFADDAKRYSATGEWEVKVNKETVFTPVTSSTPPGSPGGQTDPDTSSKTPTTTTAATDTSPRRQSINKQSQQTETKRRGYGRRPSSRTRRPQTHQRRSRSRSRSRSSSQTHSSTTTTTTTYRSRSTSLNKTRARSRSRSTSRSTSTTSRRGGRGSSTRQRSRSPSTYTSKRSREGNTRGRGRGRQGRAGSSGGREQRRRRRSFSTSPDSSKRVRRESPKYRGVSPSEVGKQLRSVGAKHSGRLGRLLEEARDPPVILVRGDANTLKCFRNRARNKYRGLFRSFSTTFSWVAGDSIERLGRSRMLISFSCLTQRRDFDDAVKYPKGVEWSYGSLDSL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: T2AG_DROME
Sequence: MSYQLYRNTTLGNTLQESLDELIQYGQITPGLAFKVLLQFDKSINNALNQRVKARVTFKAGKLNTYRFCDNVWTLMLNDVEFREVHEIVKVDKVKIVACDGKSGEF
What is the function of this protein?
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation (PubMed:7958898).  TFIIA in a complex with TBP mediates transcriptional activity (PubMed:7958898).  Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers (PubMed:28847004).  Forms a complex with Moonshiner/CG12721 and Trf2 which recruit transcriptional machinery to heterochromatin to initiate the bidirectional transcription of piRNA clusters, by interacting with the RDC (rhi, del and cuff) complex that binds to repressive H3K9me3 marks in the chromatin (PubMed:28847004).  This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark (PubMed:28847004).
What are the official names of this protein?
Transcription initiation factor IIA subunit 2, General transcription factor IIA subunit 2, TFIIA p14 subunit, TFIIA-14, Transcription initiation factor IIA gamma chain, TFIIA-gamma, dTFIIA-S.
What is the protein family that this protein belongs to?
Belongs to the TFIIA subunit 2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOLD_PSEP1
Sequence: MTAHLIDGKAIAASLRQQIAQRVVERRQQGLRTPGLAVILVGTDPASQVYVSHKRKDCEEVGFISQAFDLPSETTQQALTELIDRLNDDPAVDGILLQLPLPAHLDASLLLERIRPDKDVDGFHPYNIGRLAQRIPLLRPCTPKGIMTLLESTGQDLYGMNAVIVGASNIVGRPMAMELLLAGCTVTVCHRFTKDLAGHVGRADLVVVAAGKPGLVKGEWVKEGAIVIDVGINRQEDGKLVGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAEELHK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TRUA_BACLD
Sequence: MRMKCTISYDGHLFYGYQVQPGQRTIQDELEKALQTLHKAKERIPVVSSGRTDSGVHAVGQTIHFDSPLSIPEAKWPYALNALLPDDISVRKAEAVNDQFHARFSAKRKEYRYMIYRGRHPDVFKRYYAYHVPYDLDMEKVKEASRYLVGTHDFTSFCATKTEVKDKVRTVHELEWSDTGDGLQMRIVGSGFLYNMVRIIAGTLLDVGTGKFSPGDIEKMILAKNRDAAGRTAPAHGLYLWRVIYDN
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: RS10_CENSY
Sequence: MTQSARVKLTSINLLKLDGVCGIIMDIGKRTGVRIKGPTPLPVKKLHIATRKSPCGSGTETYEKWEMRMHRRIIDISADDKTIRRLIDLKIPDDVHLELFLT
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DBP8_CANAL
Sequence: MSFNDLGVAKWLSESLDAMKIYTPTAIQSACIPAILKGHDCIGGAKTGSGKTIAFAAPMLTQWSEDPFGIFGLILTPTRELALQIAEQFAALGANMNIKVAVVVGGEDFVQQTLALQRKPHFVIATPGRLADHILNSGEETISGLRRVKYLVLDEADRLLSNSFGSDLQRCFDVLPTSDKRQTLLFTATITDAVRALKEKPPTPGKPPVFMHEVETVDKVAIPSTLQISYVFVPSYVKEAYLNSILHLEQFKDSTAVIFVNRTTTAEVLRRMLRKLDFRVASLHSEMPQSERTNSLHRFKAGAARILIATDVASRGLDIPTVELVINFDIPADPDDFIHRVGRTARAGRKGDAVSIIGEKDIDRIQSIEERINKKMELLEDVNDDNVIKESLSATSVAKRESLMEMDKENFGERKKINRKKHGLDKVKPERVTKPKKSKK
What is the function of this protein?
ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites.  Required for vegetative growth (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CNBP_PONAB
Sequence: MSSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLPDICYRCGESGHLAKDCDLQEDACYNCGRGGHIAKDCKEPKREREQCCYNCGKPGHLARDCDHADEQKCYSCGEFGHIQKDCTKVKCYRCGETGHVAINCSKTSEVNCYRCGESGHLARECTIEATA
What is the function of this protein?
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity).  Has a role as transactivator of the Myc promoter (By similarity).  Binds single-stranded RNA in a sequence-specific manner (By similarity).  Binds G-rich elements in target mRNA coding sequences (By similarity).  Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity).
What are the official names of this protein?
CCHC-type zinc finger nucleic acid binding protein, Cellular nucleic acid-binding protein, CNBP, Zinc finger protein 9.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum.