PharMolix/UniProtQA huggingface dataset:
Protein: DUSA_HAEDU
Sequence: MHNKFYRGRFAVAPMLDWTTRHCRYFHRQFSQQALLYTEMITAPAILHAKYDLLEYDPAEQPVALQLGGSDPTQLANCAKLVQARGYTEINLNVGCPSDRVQNGMFGACLMANADLVADCIKAMQDVVDIPVTIKHRIGIDTLDSYAFLCDFIDKIQPYSQDFIVHARKAWLSGLSPKENREIPPLDYERVYQLKRDFPQLNISINGGIKTIDEIKQHLTKVDGVMVGREAYQNPALLGEIDQQLFDQNQPLITARIAVENMLPYIEQQLSKGVYLNHIVRHMLGAFQNCKGARQWRRHLSENACKQGAGIEVVEQALRFVTE
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.  Specifically modifies U20 and U20a in tRNAs.
What are the official names of this protein?
tRNA-dihydrouridine(20/20a) synthase, U20-specific dihydrouridine synthase, U20-specific Dus, tRNA-dihydrouridine synthase A.
What is the protein family that this protein belongs to?
Belongs to the Dus family. DusA subfamily.
Protein: RL13_LIMRD
Sequence: MRTTYIAKPGEVERKWYVVDAKDVPMGRLASAVASILRGKNKPTFTPHVDTGDYVIVINAAQVKLTGKKASQKMYYRHSNYPGGLKQRTAGDFLAKEPEKLLETAIKGMLPHNSLGHKQGLKLHVYAGEDHKHAAQNPEVLDITNLI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RL10_CHRSD
Sequence: MPLALEGKKAIVAEVSEAAQDALSVVVADSRGVAVSAMTELRKQARENGVQVRVVRNTLARRALEGTPWECLNETFSGPTLLAFSYEHPGAAARLFKEFAKNEKDFEVKALAYEGEFIPASELDRLATLPTRDEAIAKLMSVMKEASAGKLVRTLAALRDQKQEEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RNPH_MYCVP
Sequence: MSRREDGRLDDELRPVTITRGFTTHPAGSVLVEFGQTRVMCTASVTEGVPRWRKGSGQGWLTAEYAMLPAATHERSGRESVKGRVGGRTQEISRLVGRSLRACIDLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLAAAGKLSDPRPLSCAIAAVSVGVVDGRIRVDLPYTEDSRAEVDMNVVATDTGTLVEIQGTGEGATFPRSTLDKMLDAAMAACDQLFEIQRAALELPYPGVLPEPGEPAKKAFGS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: MTGA_ECO57
Sequence: MSKSRLTVFSFVRRFLLRLMVVLAVFWGGGIALFSVAPVPFSAVMVERQVSAWLHGNFRYVAHSDRVSMDQISPWMGLAVIAAEDQTFPEHWGFDVASIEKALAHNERNENRIRGASTISQQTAKNLFLWDGRSWVRKGLEAGLTLGIETVWSKKRILTVYLNIAEFGDGVFGVEAAAQRYFHKPASKLTRSEAALLAAVLPNPLRFKVSAPSGYVRSRQAWILRQMYQLGGEPFMQQHQLD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HEM1_METM6
Sequence: MLVVKADYKKYPIPVLEKMRIDEDEFYKKYEACVVVQTCNRIEAYFDTEVNSDIDCILNDFSGFDVLKGKTATFHFLRVSCGMESMILGENQILGQIKTSFQKARELKKTSRYLDGLFLKAIHVGQRARTETKINEGGVSIGSAAVELAEKNFGLTNRNVLLIGAGEMGTLVAKALLEKHIKAVIVSNRTYERAETLAEELKGIAVHFDKLKEAINFSDVIICATSSPHYILKKEDLNDVGNKIIIDIANPRDVDDAVREFENIKLYTIDDLRNISDKNIQKRVEEVPAVEKIINEEYEVLMKQIEKINIEEVLKDFNSYVEEIRVKELEKAIKLSKTKNPEEIMENFSKAFVKRITHDFVSYSINTSKEDLMNSAWWKNGK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: SUS5_ORYSJ
Sequence: MASKLSFKRMDSIAETMPDALRQSRYQMKRCFQRYVSKGKRLLKNQQLMEELEKSLDDKVEKEKLVEGFLGYIICSTQEAVVLPPFVAFAVRMNPGIWEYVKVHSDDLSVEGITPSEYLKFKETLYDEKWAKDDNSLEVDFGALDLSTPHLTLPSSIGNGLQFVSKFMSSKLGGKPESMKPLLDYLLTLNYRGEKLMINDTIDTVSKLQTALLLAEVFVSGLPKYTPYLKFEQRFQEWGLERGWGDTAERCKETLNCLSEVLQAPDPTNMEKFFSRVPSIFNIVIFSIHGYFGQEKVLGLPDTGGQVVYILDQVRAMEEELLQRIKQQGLHVTPKILVLTRLIPDAKGTKCNVELEPVENTKYSHILRVPFKTEDGKDLRQWVSRFDIYPYLERYAQDSCAKILDILEGKPDLIIGNYTDGNLVASLLSNKLCVTQGTIAHALEKTKYEDSDVKWREMDQKYHFSCQFTADMISMNTSDFIITSTYQEIAGSKEKPGQYEHHYAFTMPGLCRYATGINVFDPKFNIAAPGADQSIYFPFTQKQKRLTDLHPQIDELLYSKDDTDEHIGYLADRNKPIIFSMARLDKVKNITGLVEWYGQNKKLRDLVNLVVVAGLLDASQSKDREEIEEINKMHNLMDRYQLKGQIRWIKAQTDRVRNGELYRCIADTKGAFVQPALYEAFGLTVIEAMNCGLPTFATNQGGPAEIIIDGVSGFHVNPINDREAGIKIADFFQKCKEDPSYWNKVSTAGLQRICECYTWKIYATRVLNMGSTYSFWKTLNKEERQAKQRYLQIFYNVQYRNLAKAMARAGDQQARQTTTGVAPSEIVVRPKERKPQTRMQRILTRLAGQKPPVSE
What is the function of this protein?
Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways.
What are the official names of this protein?
Sucrose synthase 5, OsSUS5, Sucrose-UDP glucosyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: US28_HCMVT
Sequence: MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
What is the function of this protein?
Receptor for a C-C type chemokine.  Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine (PubMed:29882741).  Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages.  The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis.  Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling.  May also function as a G protein sink to sequester G protein from the cell surface via internalization.  Interacts with endogenous Gaq/11 subunits and thereby constitutively activates phospholipase C (By similarity).
What are the official names of this protein?
G-protein coupled receptor homolog US28, HHRF3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein.
Protein: PPAX_BACAH
Sequence: MKINTVLFDLDGTLINTNELIISSFLHTLHTYYPNQYKREDVLPFIGPSLHDTFSKIDESKVEELITSYRQFNHDHHDELVEEYETVYETVQELKKQGYKVGIVTTKARQTVEMGLKLSKLDEFFDVVVTIDDVEHVKPHPEPLQKALQLLDAKPEEALMVGDNHHDIVGGQNAGTKTAAVSWTLKGRAYLEAYKPDFMLDKMSDLLPILSDMNRS
What is the function of this protein?
Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P.  Might play a role in controlling the intracellular pyrophosphate pool.
What are the official names of this protein?
Pyrophosphatase PpaX.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PpaX family.
Protein: RBFA_ANADF
Sequence: MSTHSRPARVAEEFRHGLADVIARGLKDPRVTGFITVTGAKMSPDLKEVTAYVSIHAEDAERERTLEGLKAASTFLQREVARSLRLRHTPHLRFVYDESVARGDRIERLLKEAREKDSHGES
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBZ_CHAGL
Sequence: MILAFQLSVFALVAISFLLVVGVPVVLASPDGWSTSKNAVFSGASLWIALVFLVGVLNSFIS
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: ARP3_DROME
Sequence: MAGRLPACVIDVGTGYSKLGFAGNKEPQFIIPSAIAIKESARVGDTNTRRITKGIEDLDFFIGDEAFDATGYSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNITSFIQSLLREREVGIPPEQSLETAKAIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKAAYEEYGPSICRHNPVFGTMT
What is the function of this protein?
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity).  Seems to contact the pointed end of the daughter actin filament (By similarity).  Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline (PubMed:25739458).
What are the official names of this protein?
Actin-related protein 3, Actin-2, Actin-like protein 3, Actin-like protein 66B.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: VE7_HPV23
Sequence: MIGKQATLRDIVLEELVQPIDLHCHEELTEEVEEAVVEEEPEYTPYKIIVVCGGCETQLKLYVLATDFGIRSFQASLLENVKLVCPACREDIRNGRR
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: SYH_ACIB3
Sequence: MSSIVAIKGFNDVLPTQTAAWRRLEQHLASLMDAYGYQQIRLPIVEQTGLFKRAIGDATDIVEKEMYTFFDKGNPPESLTLRPEGTAGCVRALVEHNLLRGATPRVWYMGPMFRYEKPQKGRYRQFHQFGVETFGVATPDIDAELIMLTARLWKRMGVDHMVQLELNTLGETDERTEYRNALVAFLNEHKDALDEDSQRRLTTNPLRILDSKIESTQKILENAPKLHDFLKEDSLSHFQQLQDYLTAAGIKFVINQKLVRGLDYYNKTVFEWTTTALGSQGTVCAGGRYDGLVGQLKGKADQSVPAVGFAMGMERLLLLLEQVEQAEIVRDCEAFLVAEPAYQSKALVLAEQLRDQLEAANSNIRIKTGSQGSMKSQMKKADQAGAVYAIILGEREWEAQQLAVKELATAEQSQVALAELVPFLIEKFTK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_HELPH
Sequence: MKVYIETMGCAMNSRDSEHLLSELSKLDYKETNDPKIADLILINTCSVREKPERKLFSEIGQFAKIKKPNAKIGVCGCTASHMGADILKKAPSVSFVLGARNVSKISQVIHKEKAVEVAIDYDESAYAFEFFEKKAQIRSLLNISIGCDKKCAYCIVPHTRGKEISIPMDLILKEAEKLANNGTKELMLLGQNVNNYGVRFSSEHAKVDFSDLLDKLSEIQGIERIRFTSPHPLHMNDGFLERFAKNPKVCKSIHMPLQSGSSAVLKMMRRGYSKEWFLNRVERLKALVPEVGISTDIIVGFPNESDKDFEDTMEVLEKVRFDTLYSFIYSPRPFTEAGAWKERVPLEVSYSRLERLQNRHKEILEEKAKLEVGKTHVVLVENRREMDNQIVGFEGRSDTGKFIEVTCKEKRNPGELVKVEIISHSKGRLIAAIKGN
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALLA_PSEAE
Sequence: MRTLKIEPLTKEAFAPFGDVIETAGSDYFMINNGSTRRYHKLATVETAQPEDNAIISIFSAEKLEMPLRIRMLERHPLGSQAFIPLLGNPFLVVVAPLGDVPVPGLVRAFLTNGRQGVNYHRGVWHHPVLTIEKRDDFLVVDRSGSGNNCDEHFFTEDEQLLLDPQSNQ
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: PYRB_PSEPG
Sequence: MTPIDAKRPLQLNDQGQLRHFLSLDGLPRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFELAAQRLSADVISLNVSTSSTSKGETLFDTLRNLEAMAADMFVVRHSDSGAAHFIAEHVCPDVAVINGGDGRHAHPTQGMLDMLTIRRHKGSFENLSVAIVGDILHSRVARSDMLALKALGCPDIRVIGPKTLIPIGIEQYGVKVYTDLAEGLKDVDVVIMLRLQRERMAGGLLPSEGEFYRLFGLTTARLAGAKPDAIVMHPGPINRGVEIESAVADGKHSVILNQVTYGIAVRMAVLSMAMSGQNAQRQFDQENAQ
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: YSDA_BACSU
Sequence: MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVFGALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL
What are the official names of this protein?
Uncharacterized protein YsdA.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BCD_DROME
Sequence: MAQPPPDQNFYHHPLPHTHTHPHPHSHPHPHSHPHPHHQHPQLQLPPQFRNPFDLLFDERTGAINYNYIRPYLPNQMPKPDVFPSEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGRYLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEGMPLSPGMKQSDGDPPSLQTLSLGGGATPNALTPSPTPSTPTAHMTEHYSESFNAYYNYNGGHNHAQANRHMHMQYPSGGGPGPGSTNVNGGQFFQQQQVHNHQQQLHHQGNHVPHQMQQQQQQAQQQQYHHFDFQQKQASACRVLVKDEPEADYNFNSSYYMRSGMSGATASASAVARGAASPGSEVYEPLTPKNDESPSLCGIGIGGPCAIAVGETEAADDMDDGTSKKTTLQILEPLKGLDKSCDDGSSDDMSTGIRALAGTGNRGAAFAKFGKPSPPQGPQPPLGMGGVAMGESNQYQCTMDTIMQAYNPHRNAAGNSQFAYCFN
What is the function of this protein?
Segment polarity protein that provides positional cues for the development of head and thoracic segments.  Regulates the expression of zygotic genes, possibly through its homeodomain, and inhibits the activity of other maternal gene products.  May also bind RNA.  Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction.
What are the official names of this protein?
Homeotic protein bicoid, PRD-4.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMKL_ACTP2
Sequence: MTTQITYFATAARGFEEMLKTELEQICQAECKVTQGGVHFTTTQRGAYQALLHSRLASRILLPLVTTKIFSDLDLYATIVGINWAYIFDPRDTFFVDFNGTNREIRNTQFGAMRVKDGVVDYFERKGFTRPTVDKDHADIRIHVYLDRENMVVSLDLSGDALHMRGYREDTGKAPLRETLAAAIVLRSGWQKGTPLVDPMCGSGTLLIEAAQMQAGIAPQLHRKHWGFNAWKGHQQAVWKEVLEQAYLQQNEEIQPLFFGFDLDHRVLAKAKQNAKNAGVAHLIQWQQGDIAALKNPCPEQVGTVICNPPYGERLGTTPALIALYSVFGQRLKQQFSGWNASIFSGEPELLNCLRLRSHRQFKAKNGPLDCLQKNYQISERTAAEQQADELKFEQNAQVAPDFANRLAKNIKKIEKWAKQQGINAYRLYDADLPEYNLAVDRYDDHIVVQEYAAPKNIDEQKARQRLLDAVSATLYVTGVETNKLVLKVRQKQKGTNQYEKLANKGDYFYVTEYGAKLWVNLTDYLDTGLFLDHRLTRKMVGQMAKGKTFLNLFAYTGSATIHAALNGAKSTTTVDMSNTYLNWAEQNLELNNLPLRNNRLFQADCLQWLAECRERFELIFVDPPTFSNSKRMEDSWDVQRDHIKLMTQLKRILTTDGTIVFSNNKRGFKMDFEGLAELGLQAENISHKTLPLDFERNPQIHNCWIIRHIEN
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GME73_PESMI
Sequence: MSSATQHIPFRLDGKVALVTGSGRGIGAAMATELGRAGAKVIVNYANSKESAEKLVEEIKKLGTDAVALQADVSKVPQTVRLFDEAIKVWGRLDIVCSNAGVVSFGHLEEVTEEEFDRVFTINTRGQFFVAREAYKHLNEGGRIIMMSSNTAHAFAVPRHSLYSGSKGAIESFVKVLAIDCGKKKITVNAVAPGGTVTDMFHDVSQHYIPGGEKYTAEERQQMAAHASPLVRNGYPVDIANAVVFLASKEGEWVNGKTIGVDGGS
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of dibenzodioxocinones such as pestalotiollide B, a novel class of inhibitors against cholesterol ester transfer protein (CEPT) (PubMed:31474098).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS pks8/GME11356.  Pks8/GME11356 lacks a thioesterase (TE) domain, which is important to the cyclizing of the third ring of atrochrysone carboxylic acid, and the esterase GME11355 might play the role of TE and catalyzes the cyclization reaction of the C ring.  The lactamase-like protein GME11357 (or other beta-lactamases in Pestalotiopsis microspora) probably hydrolyzes the thioester bond between the ACP of pks8/GME11356 and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrates to form endocrocin anthrone.  Endocrocin anthrone is further converted to emodin via the endocrocin intermediate.  Emodin is then oxidized by several enzymes such as the Baeyer-Villiger oxidase GME11358, the oxidoreductase GME11367, the short chain dehydrogenase/reductase GME11373, as well as by other oxidoreductases from the cluster, to modify the A and C rings and open the B ring, and finally yield monodictyphenone.  The prenyltransferase GME11375 may catalyze the addition reaction between the C5 side chains and the carbon bone of dibenzodioxocinones.  The remaining biochemical reactions to the final product dibenzodioxocinones should be methylation catalyzed by methyltransferase GME11366 and reduction and lactonization reaction catalyzed by a series of oxidordeuctases (Probable).
What are the official names of this protein?
Short-chain dehydrogenase/reductase GME11373, Dibenzodioxocinones biosynthesis cluster protein GME11373.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RL34_CYTH3
Sequence: MKRTFQPSNRKRKNKHGFRSRMETANGRRVLAARRAKGRKRLTVSDEIPRKG
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: URE1_HELPY
Sequence: MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKVSLAQLFSIF
What is the function of this protein?
Ammonia produced by ureolysis increases the gastric pH thereby providing an environment permissive for colonization of the stomach.
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Also associates with the outer membrane upon autolysis of neighboring bacteria.
Protein: WECG_ECO81
Sequence: MNNNTTAPTYTLRGLQLIGWRDMQHALDYLFADGQLKQGTLVAINAEKMLTIEDNAEVRELINAAEFKYADGISVVRSVRKKYPQAQVSRVAGADLWEELMARAGKEGTPVFLVGGKPEVLAQTEAKLRNQWNVNIVGSQDGYFKPEQRQALFERIHASGAQIVTVAMGSPKQEIFMRDCRLVHPDALYMGVGGTYDVFTGHVKRAPKIWQTLGLEWLYRLLSQPSRIKRQLRLLRYLRWHYTGNL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: CLPX_CLOK5
Sequence: MAKNDDKKQLKCSFCGKTQDQVRRLIAGPGVYICDECIELCSEIISDEFEEDIQIDMTSIPKPVEIKNYLDQYVIGQEDSKKSLSVAVYNHYKRINSNNNSNDDVELQKSNILLLGPTGSGKTLLAQTLARFLNVPFAIADATTLTEAGYVGEDVENILLKLIQNADYDIERAEHGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQINTTNILFICGGAFDGIDSIIERRTRVSTLGFGAEIQSKKDKDIGKLLKQIMPGDLLKFGLIPEFVGRIPIIVTLEALDRAALISILKEPKNALVKQYKKLFELDDVELEFKDEALEAIADEALKRNTGARGLRAIIEETMKDVMFDIPSKEEIAKVIINKDAVSTKMPELIEAENGKRTPIKLKKSRTRKGPETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: DRE2_LEIIN
Sequence: MSSSATSTQAFSLKTRQPIPDEDALLTEEDRILKQATKGEDCTTRRRACKNCVCGRAELERKLEAEGKLEAEALAMPPGGCGNCSKGDAFRCANCPFLGQPAFDATEDGKVKLNLTDDV
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog, Fe-S cluster assembly protein DRE2 homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.