PharMolix/UniProtQA huggingface dataset:
Protein: EIF3C_BOTFB
Sequence: MSRFFRGDSSSDSSSDEEEDLYSDDEEVQEQPEEESSEDDSEEDDDDDDDSDSSSDDGAGKKTGANAFLKDDSDSDSESSGDEGVKVVKSAKNKRFEELEATAKAIENGEKINDWGSISAEFDKLNRQVAKLLQSGTIPKVYIKAIADLEDFMNETLAKQKVTPKKMNATNSRGLNAVKQKIKKASKEHQKDIDSFRADKDAYMESEDEEVVAPKQKKPRSSAAQDVAADDDDEGWGTVGKGGRTLQFTPESILKHLRTILESRGKKNTDRNEQIKIMEKLYEVAATPYQRIRVLLTIISTRFDMTTGTQTFMSQEQWKAAEKEFGTLLSVLETSREYVVVETAEPWEDDEKLPTVAEGGKFAIPGSVVSYVERLDDELTRSLQHIDPHTAEYIERLSDESDLYNNIVRTMLYQEEISKDASLNEPQRSLNRVVMRRLEHVYFKPSAVIKILDENCWKAVPAELNSTITPRGSVEDAKTLVNVLCNYLYINTEGEGLTKARAMLCQIYFEALHDNYYKARDMMLMSHLQETINSFDVHSQILFNRTLVQVGLCAFRAGLVYEAQTTLQEICGSGRQKELLAQGVMIQRYNQVTPDQERLEKQRQLPFHMHINLELLECVYLTCSMLLEIPLFAQTGSSPDIKKRVISKTYRRMLEYHERQIFTGPPENTRDHVMQASKALAQGEWKRATEFIHSIKIWELMSKPEEIKAMLSAQIQEEGLRTYLFTYAPYYDTLSVSRLSSMFDLSDRKVAAIVSKMISHEELAAALDQVSSSIIFRKGVELSRLQSLALSLSDKASGLIESNERTLETRTQGTANAFERQGGRGGRGGNRGGRGGGRGGRGGISNAPRQAGGTQFTGGALGAAVGSRA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TREA_ECO55
Sequence: MKSPAPSRPQKMALIPACIFLCFAALSVQAEETPVTPQPPDILLGPLFNDVQNAKLFPDQKTFADAMPNSDPLMILADYRMQQNQSGFDLRHFVNVNFTLPKEGEKYVPPEGQSLREHIDGLWPVLTRSTENTEKWDSLLPLPEPYVVPGGRFREVYYWDSYFTMLGLAESGHWDKVADMVANFAHEIDTYGHIPNGNRSYYLSRSQPPFFALMVELLAQHEGDAALKQYLPQMQKEYAYWMDGVENLQAGQQEKRVVKLQDGTLLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLNTLRTTSIVPVDLNSLMFKMEKILARASKAAGDNAMANQYETLANARQKGIEKYLWNDQQGWYADYDLKSHKVRNQLTAAALFPLYVNAAAKDRANKMATATKTHLLQPGGLNTTSVKSGQQWDAPNGWAPLQWVATEGLQNYGQKEVAMDISWHFLTNVQHTYDREKKLVEKYDVSTTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPKEQPCDNVPATRPTVKSATTQPSTKEAQPTP
What is the function of this protein?
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
What are the official names of this protein?
Periplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS15_MYCLE
Sequence: MALTSEQKKEILSSYGLHATDTGSPEAQIALLTKRIADLTEHLKVHKHDHHSRRGLLLLVGRRRRLIKYLSLIDVQRYRSLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: G3P1_STRAE
Sequence: MTVRIGINGFGRIGRNVFRAAAARSSELEIVAVNDLGDVPTMAHLLAYDSILGRFPEEVTAEPGAIRVGDRTIKVLAERDPGALPWGDLGVDIVIESTGIFTDAAKARSHVDGGAKKVIIAAPASGEDFTVVLGVNDGDYDPERHTIISNASCTTNCLGVLAKVLHDAVGIDSGMMTTVHAYTQDQNLQDAPHKDLRRARAAALNIVPTSSGAAKAIGLVLPELAGRLDAFALRVPVPTGSVTDLTVTTRRGTSVEEVKEAYAAAASGPYKGLLSYVDAPLVSTDIVGDPASLFDAGLTRVCGPQVKVVGWYDNEWGYSNRLIDLATLIGSSL
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 1, GAPDH 1, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase, PL-insensitive glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_BURMA
Sequence: MLTLAHYLVLGAILFAIAIVGIFLNRRNIIIILMAIELMLLAVNTNFVAFSHYLGDVHGQIFVFFVLTVAAAEAAIGLAILVTLFRKLDTINVEDLDQLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PHS_PARPJ
Sequence: MIQKLTSEQRATQLAGLHGWQAVADRDAIQRQFKFADFNEAFGFMTRVAIKAQEMDHHPEWFNVYNKVEITLSTHDAGGLTERDIKLATFIDSITA
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: RUVA_XANP2
Sequence: MIGKLKGVVDTLEEDHVILDVHGVGYLVHCSGRTLSALPRAGEAAALFIETHVREDQIRLFGFSSAAERDWFRLLQGIQGIGTKTALAVLSTLSASELTQAIALGDKTTVARAPGVGPRVATRIITELKDKMPGFSASEPLAAQLGGGGVASAQGGAAADAVSALVNLGYGVPQANAAIAAALRGAGEGAKTEVLIRLGLKELAK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: GP2_EHV1B
Sequence: MGFIYARKLLLCMAVSIYAIGSTTTTETTTSSSSTSGSGQSTSSGTTNSSSSPTTSPPTTSSSPPTSTHTSSPSSTSTQSSSTAATSSSAPSTASSTTSIPTSTSTETTTTTPTASTTTPTTTTAAPTTAATTTAVTTAASTSAETTTATATATSTPTTTTPTSTTTTTATTTVPTTASTTTDTTTAATTTAATTTAATTTAATTTAATTTAATTTAATTTAATTSSATTAATTTAATTTAATTTAATTTAATTTAATTTGSPTSGSTSTTGASTSTPSASTATSATPTSTSTSAAATTSTPTPTSAATSAESTTEAPTSTPTTDTTTPSEATTATTSPESTTVSASTTSATTTAFTTESHTSPDSSTGSTSTAEPSSTFTLTPSTATPSTDQFTGSSASTESDSTDSSTVPTTGTESITESSSTTEASTNLGSSTYESTEALETPDGNTTSGNTTPSPSPRTPSFADTQQTPDNGVSTQHTTINDHTTANAQKHAGHHRGRAGGRRGSPQGGSHTTPHPDRLTPSPDDTYDDDTNHPNGRNNSIEIVPQLPPDRPIIELGVATLRKNFMEASCTVETNSGLAIFWKIGNASVDAFNRGTTHTRLMRNGVPVYALVSTLRVPWLNVIPLTKITCAACPTNLVAGDGVDLNSCTTKSTTIPCPGQQRTHIFFSAKGDRAVCITSELVSQPTITWSVGSDRLRNDGFSQTWYGIQPGVCGILRSEVRIHRTTWRFGSTSKDYLCEVSASDSKTSDYKVLPNAHSTSNFALVAATTLTVTILCLLCCLYCMLTRPRASVY
What is the function of this protein?
Virulence factor.
What are the official names of this protein?
Glycoprotein gp2, Glycoprotein X, GpX.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein.
Protein: VM2I_CROOL
Sequence: EAGEECDCGSPANPCCDAATCKLRPGAQCADGLCCDQCRFIKKGTVCRVARGDWNDDTCTGQSADCPRNGLYG
What is the function of this protein?
Inhibits fibrinogen interaction with platelets.  Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.
What are the official names of this protein?
Disintegrin lutosin, Platelet aggregation activation inhibitor.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1413_STAA8
Sequence: MALKHYKNSDSTVFNDAKALFDLNKNILLKGPTGSGKTKLAETLSEVVDTPMHQVNCSVDLDTESLLGFKTIKTNAEGQQEIVFVDGPVIKAMKEGHILYIDEINMAKPETLPVLNGVLDYRRQITNPYTGEVIKAVPGFNVIAAINEGYVGTLPMNEALKNRFVVIHVDYIDGDILKNVIKEQSLLQDDKQIEQIIKFNEDLRTMSKQGQISEEAASIRALLDLCDLITVMPVERAIKRTIIDKLEDEREQQAIYNAVELNF
What are the official names of this protein?
Uncharacterized protein SAOUHSC_01413.
What is the protein family that this protein belongs to?
Belongs to the CbbQ/NirQ/NorQ/GpvN family.
Protein: SNDH_GLULI
Sequence: MTRSQIRLLVATTAVTALLVAAGYRAVVSPEEARQTVAAGTGPHPVLPPPNPTFMPTVNIATPVGWQGTQAPTPAAGLAVHAFATGLDHPRWLYKLPNGDILVAESESPGTDIKTVKNRIAGLVMGQVGAGGKSPDRIILLRDTDGDGIADQRSVFLDHLYSPFGMALVGDTLYVANANALVRFPYHEGETHIDAPGEKAVDLPAGYNHHWTKNILASPDGSTLYVTVGSNSNVADNGMEVEEGRARIDRFDIATGKLTPYATGLRNPNELAWEPKTGALWVAVNERDEIGSDLVPDYITAVKEGAFYGWPYSYYGQHVDVRVKPQRPDLVASAIAPDYALGPHTAWFGIAFSQDSSLPAAWRNGLFVAQHGSWNRKPKSGYRVIYVPFTDGHPDGTPRDVLTGFLTQDEDHAHGRPVGLALDKSGALLVADDVGNTVWRVTGTDQKTD
What is the function of this protein?
Converts L-sorbosone into 2-keto-L-gulonic acid (2KGA).
What are the official names of this protein?
L-sorbosone dehydrogenase, SNDH.
What is the protein family that this protein belongs to?
To B.burgdorferi BB024.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: CODY_STAA9
Sequence: MSLLSKTRELNTLLQKHKGIAVDFKDVAQTISSVTVTNVFIVSRRGKILGSSLNELLKSQRIIQMLEERHIPSEYTERLMEVKQTESNIDIDNVLTVFPPENRELFIDSRTTIFPILGGGERLGTLVLGRVHDDFNENDLVLGEYAATVIGMEILREKHSEVEKEARDKAAITMAINSLSYSEKEAIEHIFEELGGTEGLLIASKVADRVGITRSVIVNALRKLESAGVIESRSLGMKGTFIKVKKEKFLDELEKSK
What is the function of this protein?
DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability.  During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO3A_CHLPN
Sequence: MTWIPLHCHSQYSVLDAMSSIKDFVAKGQEFGIPALALTDHGNLYGAVDFYKECTQKGIQPIIGCECYIAPGSRFDKKKEKRSRAAHHLILLCKNEQGYRNLCILTSLAFTEGFYYFPRIDKDLLRQYSEGLICLSGCLSSSVSDAALKSPEALLLELQWFQDLFKDDYFTEVQLHKMSEESIAGFKEEWLKQEYYSLIEKQIKVNTAVLEASKRLGIPTVATNDIHYINANDWQAHEILLNVQSGETVRIAKQNTHIPNPKRKVYRSREYYFKSPAQMAELFKDIPEVISNTLEVAKRCDFTFDFSKKHYPIYVPESLKTLNSYTEEDRYQASAVFLKQLAEEALPKKYSSEVLAHIAKKFPHRDPIDIVKERMDMEMAIIIPKGMCDYLLIVWDIIHWAKANGIPVGPGRGSGAGSVLLFLLGITEIEPIRFDLFFERFINPERLSYPDIDIDICMAGRERVINYAIERHGKDNVAQIITFGTMKAKMAVKDVGRTLDMALSKVNHIAKHIPDLNTTLSKALETDPDLHQLYINDAESAQVIDMALCLEGSIRNTGVHAAGVIICGDQLTNHIPICISKDSTMITTQYSMKPVESVGMLKVDLLGLKTLTSINIAMSAIEKKTGQSLAMATLPLDDATTFSLLHQGKTMGIFQMESKGMQELAKNLRPDLFEEIIAMGALYRPGPMDMIPSFINRKHGKEIIEYDHPLMESILKETYGIMVYQEQVMQIAGALASYSLGEGDVLRRAMGKKDFQQMEQEREKFCKRACNNGIDPELATVIFDKMEKFAAYGFNKSHAAAYGLITYTTAYLKANYPKEWLAALLTCDSDDIEKIGKLIREAQSMGIPILPPHINVSSNHFVATDEGIRFAMGAIKGIGRGLIESIVEERDHHGPYESIRDFIQRSDLKKVSKKSIESLIDAGCFDCFDSNRDLLLASVEPLYEAIAKDKKEAASGVMTFFTLGAMDRKNEVPICLPKDIPTRSKKELLKKEKELLGIYLTEHPMDTVRDHLSRLSVVLAGEFENLPHGSVVRTVFIIDKVTTKISSKAQKKFAVLRVSDGIDSYELPIWPDMYEEQQELLEEDRLIYAILVLDKRSDSLRISCRWMKDLSIVNENIIYECDQAFDRIKNQVQKMSFTMSTSGKETKAKGNKPNENGHTQALAPVTLSLDLNELRHSHLCILKKIVQKHPGSRTLVLVFTQDNERVASMSPDDAYFVCEDIEELRQELVTADLPVRVITV
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_PYRIL
Sequence: MMETKEKVVYPRYAVIRLRGIPTTPRDIATTLHLLRLRRKFTMVVVPGTPSIIGMIQKVNDWVTWGEIDADTLAEVLKKRGRIVGDKPLTLEYLQKWGWQSFEEVALAYITGEIDSLSCRKVRVREGQRPPCIPYLKPFFRLHPPRGGLNSVKLHFSVGGDLGYRGPLINDLIRRML
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ARGB_METPE
Sequence: MKREDVLMEALPYIQQFHGQIFVIKLGGHAMVDQLVLEAAIRDVVLLSYIGISVVLVHGGGPEITDKMKAMGKEPKFVGGLRITDQETLEIAQMVLVGKINDGIVSLIAKCGARGVGISGNDGSLLIAKRKELQVVTIEDRTERVDLGHVGEIVEVDPAILQMLLSNEYIPVVAPIAIDRESNSLNINADTAAAKIAVALHAAKLINLTDVDGVMDAERTHVYRRLKVDETNEMINSGVISEGMIPKVEGMVYALDRGVGSAHIINGNTEHNLLLELFTRDGVGTMIHP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y663_METJA
Sequence: MGGNIKFLEAMVDFLERNVKTIFSYPGEQILPLYNEIEGSSIKNIMVRDERGAGFMADGYARITNYIGVCLATAGPGATNLTTPIATAYKDNSSVLAITGRCQRKYIGKNYFQEVNMDFLNFYKGYFVDKAEVSYIAKAFADCLFNKKPVQLNIPVDLYKEEAKDINITTYTDIYKDDETPSNNIKEIDVKKPLFLIGQGIFGTLSYKEIVKISKILEKINCPIATTFPARGVINEKLENCIGLVGRRGDLKSLLEADKIINIGSSLSYNTYVESVREKLLSKTENIQLKPKSIKELKEFFENLDVKNSSWIYKNSNKFQPSGDYSNKIYEIIKNIPEDAIIVTDAGKHTVFTCLLKTCVIPRNIISSHSFGTMGFGLPASIGVKFGTIDFNIDREVVLISGDGGFLMNVEELQVVAENNLKILMVVMKNNSLAEFCKIKNPNFNKIADAFEIDNCYIENVDEIGSEIKGYLKKNKPLLVVVETENEPLPKPNI
What are the official names of this protein?
Uncharacterized protein MJ0663.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: YJIS_ECOLI
Sequence: MEFHENRAKAPFIGLVQLWQAVRRWRRQMQTRRVLQQMSDERLKDIGLRREDVE
What are the official names of this protein?
Uncharacterized protein YjiS.
Protein: AB1IP_XENLA
Sequence: MDEIDEMFSNLLGEMDLLTQSLEIETLPPPTRSASTTEINFSVGFKDLNESLNALEDNDLDALMAELVADITDAEQNVATYNNKSTAPFPPADASNSYHFHPPPMPSIITEDLSLLPPPPEFDPHYPPPPPDPLTEPKTQEELESKAKANKINLALSKMKEAKVKKRIVKVHMIDSSTKTLMVEEHQTVRDVLDNLFEKTHCDCSIEWCLFEVTPELQIERFFEDHENIVEILANWTRDSVNTIHFLEKNEKYAVFKKPQNFYMATKGSADLKDMNEKNKVSLLEQSFCGASVTVPELEAALYLKEDGKKSWKKRYFLLRASGIYYVPKGKTKTSRDLACFVQFDNVNVYYGTQYRMKYKAPTDHCFVLKHPQIQKESQYIKYLCCEDPWLLHQWVTGIRIAKYGKILYDNYKTAVQRGGLASHWSTLGSSSVSTAAGSSQGNGQICQNVTTISSSFSDAWKHGEANKQEKKSSEVNKPETKSATPTVTKRPPPTPRRASSISRVTDHPAFPPKPKAINTDIMSGPPQFPPPEPLQPADDFLPPPPPDFFDAPPDFLPPSPPSFMSNAENPPPPPVTQLQMSNAPAPPPPPPPPAPAANVPPLPVKKHPPKPPKRQSIVGPMPGTNAHGGAGGQPDFMSDLMKALQKKREPPT
What is the function of this protein?
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.
What are the official names of this protein?
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, APBB1-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the MRL family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein: SMAD6_HUMAN
Sequence: MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR
What is the function of this protein?
Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators.  SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (PubMed:9436979, PubMed:16951688, PubMed:22275001, PubMed:9759503, PubMed:10647776, PubMed:10708948, PubMed:10708949, PubMed:30848080).  Acts as a mediator of TGF-beta and BMP anti-inflammatory activities.  Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688).  Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (PubMed:9436979, PubMed:30848080).  Binds to regulatory elements in target promoter regions (PubMed:16491121).
What are the official names of this protein?
Mothers against decapentaplegic homolog 6, MAD homolog 6, Mothers against DPP homolog 6, SMAD family member 6, SMAD 6, Smad6, hSMAD6.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DXS_DEHM1
Sequence: MHTGLEISIPHNLQMSKLLDTINSPSDLKKLTLDELRELAVQIREELVNRVTLNGGHLASSLGVVELTIALHRVFESPKDKIIWDVGHQSYAHKLLTGRREQFATLRQHGGLSGFTCRDESPHDPFGAGHASTSISAGLGMAVARDLAKEDYSVISVIGDGAISGGMSFEAINNAGHLHTKFIVILNDNGMAISPSTGALSKFLNNVRFDPRFEFAKRGAKQTITNMPFGKSVWAFTKSIKRKFEKSMLPGSLWEELGFIYLGPVDGHNIRELEAALKCAKDFESQPVLIHMITKKGKGYDDAEADAVKYHGIAPKSGGLKSGHGLSYSQVFGQTLHKIMSDNPKVVAITAAMTDGCGLSEVAADFPDRVFDVGICEQHAVTFAAGMATQGYIPVVVIYSTFLQRSFDQIIHDVCLQKLPVVFAIDRGGIVGDDGKTHQGIFDLSFMSLIPDMIVTAPSDENDLQHLLYTAVNSGKPFALRYPRGFGEGVETEGTLRNIPIGENEVLASGSEIAIFATGKSVAFAKEAMEILAESGIKPTLVNNRYISPLDTELILKIAGNHKYLITVEENVLSGGLGSRINTILAEAGLVNAVKIANIAVPDKFVEHGNQSLLRAKYGLDGKGIAQKVLSLMANTGEAKHQQILCP
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: EFGM_CHAGB
Sequence: MRVIRAAAALNSSCAASSRQGARYASLACRTALTSSPLAPCYSARLSGLRYFTKTHAPRAASAAEAALKQAKELAAANMTPEAAAARMTPEEAKRLSMVRNIGIAAHIDSGKTTVSERILFYTGRTKAIHEVRGRDGVGAKMDSMELERERGITIQSAATFADWKKVENGVEETYHFNLIDTPGHIDFTIEVERAMRVLDGAVMVLCAVSGVQSQTITVDRQMKRYNVPRISFVNKMDRMGSNPFKAVEMINSKLKIPAAAVQIPIGSEKEFEGVVDLIHMRAIRNDGLRGINVRVSNTIPENLKELAEQKRQELIEKLADVDDEIAEMFLEEKTPTPEQIKAAIRRATIGLKFTPVLMGSALADKSVQPMLDAVCDYLPNPGNVDNMALDRSKKEEPVKLLPYDSLPFVGLAFKLEENPYGQLTYIRVYQGTLKKGQYLFNARNDKKVRIPRIVRMHSNEMEDVNEIGAGEICAVFGVECASGDTFTDGRLPYGMSSMFVPDSVMSLSIKPKRSSDADAFSKAMNRFMREDPTFRLHVDEESEETIISGMGELHLDIYVERLRREYKVDCETGKPRVAYRETISKRAEYDFLLKRQSGGPGDYARVVGWIEPNVENAEGNKFETKVVGGNIPDKYLAACGKGFEEACIKGPLLGHKVIGAHMVVTDGATHVTDSSDYAFNLATQMAFRKAFPDAGGAVLEPLMKTTITAPAEFQGNILMLMNKRGSIVDTEVGADEFTMIAECSLNAMFGFSTHLRAATQGKGEFSMEFSHYAPAPPHLQKELVAQYEKELEAKRSK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS4_ECO45
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: LZTS2_MOUSE
Sequence: MAIVHTLPVPLEPARETATAPKTPAMGSVSSLISGRPCPGGPAPQRHHGVPGPTFFRQQDGLLPGGYEAQEPLCPAVPPRKAVPGNSFTYVNEDFRTESPPSPSSDVEDPREHQAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPGFLGPRAAGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLALSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTNSPGGHLPSHGPGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGARASPGSSSGGDRSPPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSMDESEATVCQAFGARQRRWPRERGEDCAAQAQQATQRVQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATFEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAREQELEACSQELQRYRQEAERLREKAGHLDAEASGLRDPPVPPATTDPFLLAESDEAKVQRAAAGAGGSLRAQVERLRQELQREQRRGDEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAESAPCICLEEITATEI
What is the function of this protein?
Negative regulator of katanin-mediated microtubule severing and release from the centrosome.  Required for central spindle formation and the completion of cytokinesis.  May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon.  Negative regulator of the Wnt signaling pathway.  Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
What are the official names of this protein?
Leucine zipper putative tumor suppressor 2, Protein LAPSER1.
What is the protein family that this protein belongs to?
Belongs to the LZTS2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
Protein: RL27_ECO5E
Sequence: MAHKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: MUTL_XANCP
Sequence: MAIRQLPEILINQIAAGEVVERPASVVKELVENALDAGATRVDIDLEEGGVRLIRIRDNGGGIAPEELPLAVSRHATSKIASLDDLETVATLGFRGEALPSIASVSRFTLASRRPDAEHGSALQIEGGRLGEVMPRAHAPGTTVEVRELFFNVPARRKFLRAERTELGHIEEWLRSLALARPDVELRVSHNGKPSRRYKPGDLYSDARLGETLGEDFARQALRVDHSGAGLRLHGWVAQPHYSRASTDQQYLYVNGRSVRDRSVAHAVKMAYGDVLFHGRQPAYVLFLELDPARVDVNVHPAKHEVRFREARLIHDFVYRTLQDALAQTRAGALPADVGVGGAAALGIGAVAAQGGGSYVADAGAGHPGAGSGSGYASWAPSQAPLGLRVDEARAAYAALYAPAAGSALRDDGQPVLSGTGLPATAHDSGVPPLGYAVAQLHGIYILAENAEGLIVVDMHAAHERIGYERLKQAHDSIGLHAQPLLVPMTLAVGEREADTAEREADTLASLGFEITRSGPQSLHVRSIPALLANADPEALLRDVLGDLREHGQSRRIATARDELLSTMACHGAVRANRRLTVPEMNALLRDMEATERSGQCNHGRPTWARFTLGEIDRWFLRGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.