PharMolix/UniProtQA huggingface dataset:
Protein: GCSP_NOCFA
Sequence: MTRSFADRHIGPDAAELSRILEVVGVDSLDALAAAALPASILDDAGAGPLAALPPAVSEHEALAELAALAQSNTVTTSMIGLGYYDTLTPPVLVRNLLENPAWYTAYTPYQPEISQGRLEALLNFQTMVSDLTGMEVANASMLDEATAAAEAMTLLRRAGRSRSNRLLIDADLFPQTRTVLHTRAEPLGIEIVEADLAAAGLPEGGFFGVIVQVPGASGRVVDWTALIAAAHERGALVAAGADLLAMTLIVPPGEQGADVCFGTTQRFGVPMGFGGPHAGYLAVRSAHARQLPGRLVGVSKDADGNPAYRLALQTREQHIRREKATSNICTAQVLLAIVAAMYACYHGADGLRAIARRVHGHAARIAGALGEALVHDTYFDTVLARVPGHAEAVVAKAAACGITLRLVDPDHVAVACDEATTDAHVEAVLDAFGVAPAEPVDAGIATRTSEFLTHPAFTRYRTETAMLRYLRSLSDKDIALDRSMIPLGSCTMKLNATAEMEPITWPGFAKLHPYAPVEHAPGLLKLIGDLESWLAEITGYDAVSLQPNAGSQGEYAGLLAIRRYHLDRGDTHRDTCLIPSSAHGTNAASAAMAGLRVEVVKCRENGDVDLDDLRAKITDHAERLACIMITYPSTHGVYEHEIAELCALVHDAGGQVYVDGANLNALVGLARPGRFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLAQYLPGDPLESGSHAVSAARYGSASILPITWAYIRMMGAEGLRKATLTAIASANYLARRLDEYFPVLYTGENGMVAHECILDLRELTKRTGVTVDDVAKRLADYGFHAPTMSFPVAGTLMVEPTESENLAELDEFVAAMIAIRAEIDQVGAGVWPAEDNPLRGAPHTAECLVGEWTHPYSREIAVYPRGLGHARAKVWPAVRRIDGAYGDRNLVCSCPPLEAYAE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: RUTB_METC4
Sequence: MEADAPAGYRDPSGRHGAVTLPARPEPIAFDADTTVLIVVDMQNAYATKGGYLDLAGFDVSATGPVIERIAQAVAAARAAGIRVVWFQNGWDPDYVEAGGPGSPNWHKSNALKTMRRRPEMNQRLLAKGTWDYALVDALTPEPGDIVLPKPRYSGFYNTPLDSMLRARGIRTLVFTGIATNVCVESTLRDGYHREYFGIVLADATHQAGPPALQEGALRNIETFFGWVSDVAAFEAALSSDEARRIPA
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: Y1398_METMP
Sequence: MKSILDETIELSSDLISINSVNPTFGGIGEKEKSIYIKNKLEEYNKNYSIKNCEITEYNTVDSEGIERPNIVSKYDFGKNDTLTIISHMDIVPEGDLGLWNSDPFKAEIKDGIIYGRGSEDNHKGIVSSFLLLKMIFEEKIDPKYNLNLIFVADEEDGSKYGLSYLVNNFEDEIFSSKDLIIVPDFGMPEGEFIEIAEKNILWLKFKITGKQCHGSVPENGINADLIAFSFGKGLYDKLYGKYDGINPIFNPAFSTFEPTILKNNIENINTIPGYVELNFDCRIIPKYDPKEVLSDIENYIEVFKNEIEKHILHFDISEKENISITYEILKLEKAEETKKDSEVVKKLGSAIKNVLNKESVLCGMGGGTVAAFLREKGYNTAVWGIGDETAHQPNEHIKIENLIKMAEVYLDILK
What are the official names of this protein?
Uncharacterized metallohydrolase MMP1398.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: RPOC_MYCMM
Sequence: MLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDNEMRHNELSTLEAEMMVERKAVEDQRDADLEARAQKLEADLAELEAEGAKADARRKVRDSGEREMRQLRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELQDRYGEYFTGAMGAESIQKLIETFDIDAEAEILRDVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVEGDKGAYQPAGQDSPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPPAEIEDALFGHNGWQPGDAWTAETTLGRVLFNELLPLGYAFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDSGFYWATRSGVTVSMADVLVPPRKKEILDSYEERAEKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPADNPIITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPIKSSFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIMVELAERQGDGTLIRDPYIETSAYARTLGADAVDEAGNVVVARGEDLGDPEIEACLAAGITQVKVRSVLTCTTGTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKLSKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGATEFLPGSLIDRAEFEAENRRVVAESGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRNIAVQPTEEARAAAYTIPSYEDQYYSPDFGQATGAAVPLDDYGYSDYR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: VE1_HPV17
Sequence: MTDDNKGTKFDPKEGCSQWCILEAECSDNSLDGDLEKLFEEGTDTEISDLIDDEDIIQGNSRELLCQQESEESEQQIQLLKRKYLSSQEVLQLSPRLQSITISPQHKSKRRLFERDSGLELSFNEAEDLTQQTLEVQEVSATGSVPAEQGVKGLGIVKDLLKCSNVKAMLLAKFKEAFGVGYMDLTRQYKSSKTCCRDWVVTLYAVQDELIESSKQLLLQHCAYIWLQHMSPMCLYLLCFNVGKSRETVSRLLMNILQVAEVQMLAEPPKLRSMLSALFWYKGSMNPNVYAHGEYPEWILTQTMINHQTAQATQFDLSTMIQFAYDNEYLQEDEIAYHYAKLADTDANARAFLQHNSQARFVKECAIMVRHYKRGEMKEMSISTWVHRKLLVVEGDGHWSDIVKFIRYQDINFIRFLDIFKSFLHNKPKKNCILIHGPPDTGKSMFTMSLIKVLKGKVLSFANCRSNFWLQPLADTKLALIDDVTFVCWDYIDQYLRNGLDGNVVCLDLKHRAPCQIKFPPLLLTSNIDVMKEDKYRYLHSRIQSFAFPNKFPFDNNNMPQFRLTDQSWKSFFERLWHQLDLSDQEEEGDDGQSQRTFQCTAREPNGHL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: SYH_PSEF5
Sequence: MSKSLQAIRGMNDILPEQTPLWRYFEGTVARLLDNYGYKQIRMPIVEFTELFKRSIGEVTDIVEKEMYTFEDRNGDSLTLRPEGTAACVRAVLEHGITGGGQVQKLWYIGPMFRHERPQKGRYRQFHQIGCEVFNLDGPDIDAELIVLTWRLWGELGIRDAVKLELNSLGTAEARARYRDALVEFLSARMDKLDEDSQRRLKTNPLRVLDTKNPDTQAVLVDAPKLADYLDEESRVHFEGLKARLDAAGIPYVINPKLVRGLDYYSKTVFEWVTDKLGAQGTVCAGGRYDGLVEQMGGKPTSGVGFAMGIERLVLLLETLEQVPEEISRQVDVYLCAFGEAAELAALALSERVRDQLPNLRLQINAGAGSFKSQFKKADKSGALYALILGDDELAQQVVGFKPLRGQGEQQSIAWDALAAHLATCVVQG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_CAMJE
Sequence: MMKIKIIFSYDGSAFLGSATQPHKKGVQDALSGALSHLGIFSPLLMASRTDKGVHASYAVASVECGDYFTNLEYLQKQLNKFSHPFIHIKKIEKVKDDFEVRFDVKSREYRYIFSHASYSPFMASYVHFYPKFDLGKANELLGFFVGKKDLKFFCKSGGDNKTTLREIFIARAYAYKDFSIFHFKANGFLRGQIRLSVASVLKVLEGKMSEKELKEQIEAKKQYNHFLAPPNGLYLSRICY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: NHAA_AZOC5
Sequence: MSGPSRTQRPMSPLRAFFHHETSAGLVLMACALAAIAVANSPLAPGYFATLHAYAGPLSVQHWVNDGLMAVFFLLVGLEIKREILTGQLATWGKRTLPGVAAVGGMAIPGIVYVMLNLNNPDALRGWAIPAATDIAFALGVMSLLGSRVPSSLKIFLAALAIIDDLGAVIIIAIFYTANINVATLLGAVFVFGILRSLCAANFQDLRIYLALGAVLWVLLLVSGVHATLAGVLLALTIPITTASATPDPSRQTAPLHRLESLLHAPVAFAILPIFGFANAGVSFASITPAIMTDTLAVGVAAGLLIGKVVGIFGAVALMVRLRLAELPTHATWLQVLGVAFLCGIGFTMSLFIGLLAFEDPHMQDRVKYGILAGSLLAGVLGYGILRIAGRRAL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RK33_EPIVI
Sequence: MAKSKDARVAVILECTSCIRNSVNKVLTGISRYITQKNRRNTPNRLELRKFCPYCYKHMIHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, plastid.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid.
Protein: CYSI_SHIDS
Sequence: MSEKHPGPLVVEGKLTDAERMKLESNYLRGTIAEDLNDGLTGGFKGDNVLLIRFHGMYQQDDRDIRAERAEQKLEPRHAMLLRCRLPGGVITTKQWQAIDKFAGENTIYGSIRLTNRQTFQFHGILKKNVKPVHQMLHSVGLDALATANDMNRNVLCTSNPYESQLHAEAYEWAKKISEHLLPRTRAYAEIWLDQEKVATTDEEPILGQTYLPRKFKTTVVIPPQNDIDLHANDMNFVAIAENGKLVGFNLLVGGGLSIEHGNKKTYARAASEFGYLPLEHTLAVAEAVVTTQRDWGNRTDRKNAKTKYTLERVGVETFKAEVERRAGIKFEPIRPYEFTGRGDRIGWVKGIDDNWHLTLFIENGRILDYPGRPLKTGLLEIAKIHKGDFRITANQNLIIAGVPESEKAKIEKIAKESGLMNAVTPQRENSMACVSFPTCPLAMAEAERFLPSFIDNIDNLMAKHGVSDEHIVMRVTGCPNGCGRAMLAEVGLVGKAPGRYNLHLGGNRIGTRIPRMYKENITEPEILASLDELIERWAKEREAGEGFGDFTVRAGIIRPVLDPARDLWD
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: HIS2_CLOAB
Sequence: MDKNEILSKLYNVIEDRKNNPIEGSYTNYLFEKGIDKILKKVGEETTEVIIASKDDNKEDLINEICDVIYHTLVLLNYKNIKLEDIEKELQKRNEKILNKKQERRPIENI
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_LACLM
Sequence: MTKITGIIAEFNPFHKGHEYLLNQIDGLKIVAMSGNWMQRGEPAIFDKWTRAEMALSCGADLVVELPVMVSVQAADFFASGAVDILKNLGITDLAFGSESAIDYNEIADIYETKETEMESFIKALPDQLSYPEKTQMMWQHFTGIKFDGNTPNHVLALAYAKAAAGKNINLQAIKRVGKFHSTKLTEGFASATALRQQLFSLTDEVGQSLFSLTDLSAIENHVPSVILETYASPKTNWAAYFPLLQYKIRLDDHLENIFQVNQELSVRLKNAIKSAKNFDELVELVYTKRYTKARVRRLLTYILLNIPKEFNLPKEIHILGFSKAGQEILAQNRGKIISKIGQKPWDELTQKADEIYQLGNVDFKEQNFGRKPIIKREK
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSP7E_PONAB
Sequence: MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNISNTVMKVKQILGRSSNDPQAQKYIVESKCLVIEKNGKLRYEIDTGEETKLVNPEDVARLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFKLGGTSLSLSIMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKYDVRGNARAMMKLMNSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQSGFTADDINKVVLCGGSSRIPKLQQLIKDIFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLMIECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQAPGSISSVCLELYESDGKNSAKEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIEVAS
What is the function of this protein?
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.  In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity).
What are the official names of this protein?
Heat shock 70 kDa protein 14.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RSMH_RHOCS
Sequence: MTAGPTPGAVDAPSLHIPVLRDEVVDALAPRDGAVLVDGTFGAGGYTAALLASAACTVWAIDRDPAAVARGHALAARHPGRLTVLDGTFGCMESLLAAHGITRVDGIALDIGVSSPQIDDPSRGFSFRFDGPLDMRMGSHGTTAADIVNERDEAEIADIVWRYGEERHSRRVARAIVARRREAPITRTLDLAEIVRSVVPKSKDGIDPATRTFQALRIAVNDELGELERGLAAAERLLAPGGRLAVVTFHSLEDRVVKEFLRSRSAAAPAPSRHLPAPADAPAPTFRLIARSGVTPAPAELAANPRARSARLRSAERTSAPARRLGDAA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_CLOPE
Sequence: MKVHVRKNDTVVVISGKDKGKTGEVLRVIPKTGKVVVKGVNLVKKHQKPNRQNMQGGIIEMEAAINSSKVMLFCEKCKKATRISHKLLEDGAKVRVCKKCGETF
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RL25_NEIM0
Sequence: MTYEIQASVREAQGTGASRRLRREGQIPGILYGEGQEPVAIAVDHKTVFYALEKESFHTALIKLSLNGETKDVIVRDFQMHPFRREVQHIDFQAVKADQLVRIRVPLHIVNAENSQAVKLQGGRVSLLNTSVEVVALPANIPAFLDLDCAEVVAGDILHLSDIKLPEGVESVSLKRNENLAVATVTGKKR
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: Y1660_MYCLE
Sequence: MTVALALRDGCRRISTMTRQYGVTTQRHLISPVVFDITPLGRRPGAIIALQKTVPSLARIGLELVVIEWGAPINLDLRVESVSEDVLVAGTVTAPTVSECVRCLTAVHGHVQVTLNQLFAYPYSATKVTTEEDAVGHVVDGTIDLEQSIIDAVGIELPFAPMCRSDCPGLCAECGTSLVVEPGHPHDRIDPWWAKLTDMLAPDVPQTSETDGSRSEW
What are the official names of this protein?
Uncharacterized protein ML1660.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv2926c.
Protein: PYRB_STAA8
Sequence: MNHLLSMEHLSTDQIYKLIQKASQFKSGERQLPNFEGKYVANLFFENSTRTKCSFEMAELKLGLKTISFETSTSSVSKGESLYDTCKTLESIGCDLLVIRHPFNNYYEKLANINIPIANAGDGSGQHPTQSLLDLMTIYEEYGYFEGLNVLICGDIKNSRVARSNYHSLKALGANVMFNSPNAWIDDSLEAPYVNIDDVIETVDIVMLLRIQHERHGLAEETRFAADDYHQKHGLNEVRYNKLQEHAIVMHPAPVNRGVEIQSDLVEASKSRIFKQMENGVYLRMAVIDELLK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: HMDH2_YEAST
Sequence: MSLPLKTIVHLVKPFACTARFSARYPIHVIVVAVLLSAAAYLSVTQSYLNEWKLDSNQYSTYLSIKPDELFEKCTHYYRSPVSDTWKLLSSKEAADIYTPFHYYLSTISFQSKDNSTTLPSLDDVIYSVDHTRYLLSEEPKIPTELVSENGTKWRLRNNSNFILDLHNIYRNMVKQFSNKTSEFDQFDLFIILAAYLTLFYTLCCLFNDMRKIGSKFWLSFSALSNSACALYLSLYTTHSLLKKPASLLSLVIGLPFIVVIIGFKHKVRLAAFSLQKFHRISIDKKITVSNIIYEAMFQEGAYLIRDYLFYISSFIGCAIYARHLPGLVNFCILSTFMLVFDLLLSATFYSAILSMKLEINIIHRSTVIRQTLEEDGVVPTTADIIYKDETASEPHFLRSNVAIILGKASVIGLLLLINLYVFTDKLNATILNTVYFDSTIYSLPNFINYKDIGNLSNQVIISVLPKQYYTPLKKYHQIEDSVLLIIDSVSNAIRDQFISKLLFFAFAVSISINVYLLNAAKIHTGYMNFQPQSNKIDDLVVQQKSATIEFSETRSMPASSGLETPVTAKDIIISEEIQNNECVYALSSQDEPIRPLSNLVELMEKEQLKNMNNTEVSNLVVNGKLPLYSLEKKLEDTTRAVLVRRKALSTLAESPILVSEKLPFRNYDYDRVFGACCENVIGYMPIPVGVIGPLIIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLIRSGACKIWLDSEEGQNSIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVKSVLKSDVSALVELNISKNLVGSAMAGSVGGFNAHAANLVTALFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHPTEPGANARQLARIIACAVLAGELSLCSALAAGHLVQSHMTHNRKTNKANELPQPSNKGPPCKTSALL
What is the function of this protein?
HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway constitutes by the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:3065625, PubMed:3526336).  HMG1 and HMG2 catalyze the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate that is the rate-limiting step within the first mosule (PubMed:3526336).  The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA.  The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.  The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672).
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2, HMG-CoA reductase 2.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.
Protein: CHA6_LYMDI
Sequence: MNSFALLLVCIQACLVQSVFSQCTSRAAVAADRGIIGGYGLGTPCGLGYGLEAPYGRAGYADYGYPAGAYGIDAYGGIGEGNVAVAGELPVAGTTAVAGQVPIMGAVKFGGDVCAAGSVSIAGKCACGCGEYGYGLGAPYLY
What is the function of this protein?
This protein is one of many from the eggshell of the gypsy moth.
What are the official names of this protein?
Chorion class A protein Ld12.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: RIBD_AQUAE
Sequence: MIREIDKNYMKLALSLAKKRKGYTHPNPTVGAVVVKEGKIVGLGYHEKAGKPHAEVMALGQAGEKAKGATLYVTLEPCTHFGRTPPCTDAIIRSGIKRVVVATLDPNPLMSGKGVEKLRNAGIEVDVGVCEEEARELNEDFFTYITQERPYITLKWAQTLDGKLATLTGSSKWITSKESRKVAHILRREATAVLVGVNTVIKDDPHLTVRFVPTEKQPVRIILDPELEVPLSAKVLNTEEAPTIVITKKENEKAEKLKEKGVQVLILKGFNLKNILKKLKELEIMHLMVEGGPRTLTSFLKEGFFDRIVVFIAPKIMGEGLSIGDLGIRSIEESLKVRKKKVENLGEDLVIFFKRY
What is the function of this protein?
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibD.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the HTP reductase family.
Protein: SYTC_SULTO
Sequence: MEEYKGVWLKAGIIYALNLASNGFKPVEVGLGERDFYVDVESDTTLTLDEAKKFATYNQYSYQLKDGYIEFNGNKIKVLGEPSSLEPKYFEILNISVHHPSPNVQYVRIRGVGFEKKEELDQYLKWLEEVSEYDHRIIGERLDLFSFPDETAPGLALFHYKGQIIRKELMKFMEEINESMGYQEVFTAEIYRSILWKTSGHYDYYKDKMVLFKMEDEELGLKPMNCPAHILIYKSKTRSYKDLPIRFSEFGLVFRWEKRGELYGLLRVRGFVQDDGHIFLTEDQIKDEVKMLVKKTIDVLSIFGFKGDDVRINLSTRPDESIGSDELWEKATNALVSALNELGIKYIVKEKEGAFYGPKIDFDIRDSLGRWWQLSTIQVDFNLPERFKLEYIDKDGSRKRPVMIHRAIYGSIERFMAILLEHFRGKLPTWLSPVQVRILPISKDVEDYALNLLSKLKENKIRVELDMSDETLSKRIKKAYDEGVPYMIIVGKKEREEGKVTVRGRNNVEIRGVKFDDFLKALLEEIRNRDLNQSAINKLK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein.
What are the official names of this protein?
Threonine--tRNA ligase catalytic subunit, Threonyl-tRNA synthetase catalytic subunit, ThrRS-cat.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGN5_PAEDI
Sequence: MPAPAEVQAATLQRFLAAWQKWDAQEWLDGFADDFTQITLPLSLGIPSRSRAEVEQVLPALVATVKSYQLTIRTVVHDPERNKAAVYALSTGTLPWGPWELEYSVFITFSEAGDQVAVLEEMMDSAFLQEFGPKFGQYLQANGGPRAVAAGVGAGGATAVH
What is the function of this protein?
Monooxygenase; part of the gene cluster that mediates the biosynthesis of agnestins, dihydroxy-xanthone metabolites (PubMed:30746079).  The pathway begins with the assembly and cyclization of atrochrysone thioester by the non-reducing polyketide synthase Agnpks1 (PubMed:30746079).  The atrochrysone carboxyl ACP thioesterase AgnL7 then breaks the thioester bond and releases the atrochrysone carboxylic acid as the first enzyme-free intermediate (PubMed:30746079).  The decarboxylase AgnL1 then catalyzes the concerted decarboxylation-elimination required to convert atochrysone carboxylic acid into emodin anthrone, which is further oxidized to emodin by the anthrone oxygenase AgnL2 (PubMed:30746079).  Emodin then undergoes reduction catalyzed by the oxidoreductase AgnL4 to yield the dihydroquinone tautomer which is the substrate for reduction by the short chain dehydrogenase AgnL6 reduction to produce hydroxyketone, followed by AgnL8 dehydration and likely spontaneous autoxidation to chrysophanol (PubMed:30746079).  Baeyer-Villiger oxidation by the oxidase AgnL3 leads to monodictyphenone via cleavage of the C-10/C-10a bond of chrysophanol (PubMed:30746079).  Alternative cleavage at the C-4a/C-10 bond of chrysophanol leads also to the formation some cephalone F (PubMed:30746079).  Further conversion to agnestins A and B, requires reduction to dihydro-monodictyphenone, oxidation to agnestin C probably via an epoxide, and rearrangement to either agnestin A or agnestin B directly, although agnestin A or agnestin B can also interconvert (PubMed:30746079).  Within the cluster, AgnR1 is the only unassigned oxidoreductase present which could be involved in this conversion.  However, AgnR1 seems not to be involved in this step, and thus genes involved in the proposed oxidation/reduction may be located elsewhere on the genome (PubMed:30746079).  Further agnestin A derivatives are probably formed by spontaneous decarboxylations, dehydrations and methanolysis reactions (PubMed:30746079).
What are the official names of this protein?
Monooxygenase AgnL5, Agnestins biosynthesis cluster protein L5.
What is the protein family that this protein belongs to?
Belongs to the avfA family.
Protein: RECR_STAHJ
Sequence: MHYPEPISKLIDSFMKLPGIGPKTAQRLAFHTLDMKEDDVVQFAKALVDVKRELTYCSVCGHITENDPCYICEDKQRDRSVICVVEDDKDVIAMEKMREYKGLYHVLHGSISPMDGIGPEDINIPTLIDRLKDEEVKELILAMNPNLEGESTAMYISRLVKPIGIKVTRLAQGLSVGGDLEYADEVTLSKAIAGRTEM
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.