PharMolix/UniProtQA huggingface dataset:
Protein: MED14_ASHGO
Sequence: MTIAVKESKILYGNFDKAKSGIMKGSGGIVEQGPGLQQRIITPAKEMPPEIPHVEFNQLPLSVLIRNLTVYAAKELSQYMKTNVRSTQDASTRKMEFLRLIIFLRNQFLRLYVLVKWCKTIRQNNFHTMIDLLNWFRGTNIIVNNCLLALKDMSTSMAGAKLPNPDLITALEVLMLGRPDLPTHGFLLTGDENGQQANKIPAKLILKRFRDLNTCLSVKISLMDLPAEMHTYSIKDGRITFTVFPEFEISLSTIDRESPLFFVDVKFLFNENKFPLNTTKIALLVNDILYKSPTPLLSLYQFLHRYVLTLQLYMIHVELQDIETNGKYSGGNLAHHYDPKKNIISLRYWLQSKMNSKCKALIGVEKTSQSIILQWHLPDTKEEGKTTKYNNLLGNIEAILDEITFNHARIIMSELLDTGLFEGDDNKNDTSDTLFFHVPVICVATAPVQLKINTISGIFYFKNPSALLLSYAKQLNQTSDLDDVVNILERLRMDKIVHILRNMFEKTGWICEDVVKLNKPILYDKHKDKKRILTRDLFIRIKDWPANWFFILNLVASGATCIVEKLIGKVQSVKGTWEVKYLDQGNLQVSKLESITYQNVMHMQKTIIQKILNHMIIDSLNELKISKVICQGEASQKLPAYVQTNTAGASNVSIIAIGLESFLQGSKALSDTLESTIFLKMDYEQNEVKLFGKFKKDTQMIRYQCDDLLINFIDKRGLAFHMTEDFTSLNHVVQYLTKFRQKLMQLVVLTDVTEKLHNNFRSEHFQIVKLRPNEISFRYLKNSKDDQDCTIQIVTNETKIEKLQVQLSPLNPQNIIQKYLECDKYDPHFIFNYLHFTSKLFSAVKSIESITNTNTMTITLHLHTLAAYQLSYHDRLTGGQIALCIDLRNSPSRAGSMYHLYFAQEDYSASKNPMYPAILQVINNVFMLNNNTKRKVPSVIRLGTGVACPLGDIEPLLEEIHSILIRS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EX7L_ALKCK
Sequence: MAGNAGVAEAWTVSEATRYIKQLLEDDPHLPEIWIRGELSNFKQHTRGHMYFTIKDEGSRMQAVMFAGYNRFLRFKPENGMNVLIRGEINVYEPYGQYQFYAKEMQPDGIGSLFAEYERLKKALEAEGLFAEERKRPIPRFPTHIAIITSPTGAVIRDMMTTLKRRYPQIRVTLFPVLVQGEGAPLSISRALEQASMANIFDVVIVARGGGSIEELWAFNEEMVARAIAEAAVPVISAVGHETDFTISDFAADRRAPTPTAAAEFAVPDARELMEHIGHLKKRLERSLVEQVKTRRRELERLKRSYAFRYPVQLVHQKEQQLDGLMERLNRAMQIKLEQKTLAFKHMNQAILRQHPATRVSQLQKERRQNHARLVRAMAAETQRKRQSLSAVIQQLQLLSPLAVMDRGYSLVYKDEALVKTAKDVEIEDDIVVKLADGNLHCQVVGKREMKNGGESNG
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAM13_SCHPO
Sequence: MQNFMNNLSGGSNKEGGEKSNDFLSSALGAEKQVKQAQTMKKISDMFPGSTSEKLAILNKINSASGGRVLETLGEIENSSSSQDEIITKLKGFLK
What are the official names of this protein?
Uncharacterized protein tam13, Transcripts altered in meiosis protein 13.
Protein: GSTF2_ORYSJ
Sequence: MAPMKLYGSTLSWNVTRCVAVLEEAGAEYEIVPLDFSKGEHKAPDHLARNPFGQVPALQDGDLFLWESRAICKYVCRKNKPELLKDGDLKESAMVDVWLEVESNQYTPALNPILFQCLIRPMMFGAPPDEKVVEENLEKLKKVLEVYEARLTKCKYLAGDYISVADLSHVAGTVCLGATPHASVLDAYPHVKAWWTDLMARPSSQKVASLMKPPA
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Probable glutathione S-transferase GSTF2, GST-II.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Phi family.
Protein: RF3_SYNP6
Sequence: MGVHSFLCSSPWFRMVTDLQKEIQEAVQQRRNFAIISHPDAGKTTLTEKLLLYGGAIQEAGAVKAKRSQRAATSDWMELEKQRGISITSTVLQFNYHDCTINLLDTPGHQDFSEDTYRTLAAADNAVMLEDAAKGLEPQTRKLFEVCRMRNIPIFTFFNKMDRPGREPLELLDEIEQELGLQTYAVNWPIGSGDRFRGVFDRRKQQVHLFERSVHGKRQAKDTTLEWGDPQLADLIEPDLLQQLQDELELLEGVGTEFDLEAIHAGQLTPVFWGSAMTNFGVELFLEAFLDYALKPGARRSSVGDMAPDYPEFSGFVFKLQANMDPRHRDRIAFVRVCTGKFEKDMTVQHARSGRTLRLSRPQKLFGQDREVLDDAYPGDMIGLNNPGMFAIGDTIYTGKRLEYDGIPCFSPEIFAYLRNPNPSKFKPFRKGVSELREEGAVQIMYSADSAKRDSILAAVGQLQLEVVQYRLENEYGVETLLEPLPFSVARWVEGGWDVLEKVGRLFNTTTVKDTWGRPVLLFKNEWNLRQIEADHPELQLRSVAPVAAGQKPIEV
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_GEMAT
Sequence: MASIVAVSAREILDSRGNPTVEVDVVLETGAAGRAAVPSGASTGEREAVELRDGDPARYGGKGVLNAVNNVNTEIAEALEDMDATDQIAVDRALLDLDGTENKGRLGANAMLGVSMAVARAAAFEVGLPLYRYLGGPMARTLPVPMMNILNGGAHATNTVDFQEFMIIPVGADSFADGLRMGTQVFHQLKKVLVSRKLSTGVGDEGGFAPNLASDEEALKVIIEAIEAAGFRPGQDIALALDVAASELFQNGQYHFKKSGAPSRSPKDMAEMYAGWLEQYPIVSIEDGMSENDWDGWKLLTEKIGDRCQLVGDDLFCTNSEILAKGIENDVANAILIKVNQIGTLTETFEAIELARSAGYNSVISHRSGETEDTFIADLAVATQAGQIKTGAPSRSDRVAKYNQLLRIEEQLEGYAEYPGGAIFGI
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DMKN_BOVIN
Sequence: MKLKGSLACLLLFLLLGSGEASPLQSGEENTREEVGEAIGHGVGEALGDVLGEAAIHGIEKAIGQGTGKTEGLGIREARDPHLGDALAHKLKEASHALKNTGSEADRQAENIIGHGVDPAHKSWQGTPGSNGAWGTNGQPPSGGHGIPGSQGSSGGPGDTQDQVFSGGSGGSFGANAQGGSWGQGGHRGAFNLGANSQGTSPQPGSVRSNNNRNTECTTPPGSGGSSGNSGGSSSSGSSTNGGGSSGGSNGGSNGSTSSNSGSSNGGGSSNSGGSNGGGSNGGGSSNGGGSNAGSSGSSGSSSDTRNSDHGGSSQGYNPSPSSGSRVGSGVRNKPECDNPHVSGGSGGQGQGSSGEGEAVSGINTLNSQTSSESFNFDTFWKNFKSKLGFINWDALNKGQAPPPSTRALLYFRRLWEDFKHNTPFLNWKVITEGEDLPSLQKRAGGAGQPGTGWQDAVAGTAKNYNYNQQGPPAALGGQYPAKTPAKGGVTVSSSASRTYPGLLQWVKFW
What is the function of this protein?
May act as a soluble regulator of keratinocyte differentiation.
What are the official names of this protein?
Dermokine.
What is the protein family that this protein belongs to?
Belongs to the dermokine family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL7A_METTP
Sequence: MARPIYVRFDVPPELASKSLEALELARDTGRIKKGTNEATKAVERGVAKLVIIGEDVEPPEIVAHLPPLCEEKNTPYVYVKKQSDVGAAAGLSVKSAAAAIIEPGKGKELLEEIIQKLQALK
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPLA_CROS8
Sequence: MSSLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKSVSTAIVINALAQLGIPASASGRNDLVVETAEGPRKISGSAYRETMDRGFHHGTLLLNADLSRLSNYLNPDKKKLQAKGITSVRGRVANIHDLKPGVTHAQICEAVTEAFFAYYGERVAAEVISPDAFPDLPGFAETFARQSSWEWNFGQAPAFTHQLDERFVWGGVELHFDVEKGHITRTQLFTDSLNPAPLEALASRLQGCVYQASALQGVCEALVSEFPAQAAELREVGAWMAQAVR
What is the function of this protein?
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoate-protein ligase A, Lipoate--protein ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STAR_SHEEP
Sequence: MLLATFKLCAGSSYRHVRSMKGLRQQAVLAIGQELNRRALGGPAPAAWIYQVRRRGSLLGSQLEDSLYSDQELAYIQQGEEAMQRALGILKDQEGWKKESRQVNGDEVLSKVIPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPSVKEIKVLQKIGKDTIITHELAAEAAGNLVGPRDFVSVRCTKRRGSMCVLAGTATLYEEMPQQKGVIRAEHGPTCMVLRPLAGSPSRTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKRLESCPALEARC
What is the function of this protein?
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone.  Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).
What are the official names of this protein?
Steroidogenic acute regulatory protein, mitochondrial, StAR, START domain-containing protein 1, StARD1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PYY_ATRSP
Sequence: YPPKPENPGEDAPPEELAKYYSALRHYINLITRQRY
What is the function of this protein?
Elicits an increase in arterial blood pressure.
What are the official names of this protein?
Peptide YY-like, PYY, Neuropeptide Y-related peptide.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: VPK8_HUMAN
Sequence: WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVIGLVGIGTASEVYQSMEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMTKRGYIPGKGLGKNEDGIKIPFEAKINQKREGIGYPF
What is the function of this protein?
Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle.  Endogenous Pro proteins may have kept, lost or modified their original function during evolution.
What are the official names of this protein?
Endogenous retrovirus group K member 8 Pro protein, HERV-K115 Pro protein, HERV-K_8p23.1 provirus ancestral Pro protein, Protease, Proteinase, PR.
What is the protein family that this protein belongs to?
Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.
Protein: ACCA_ALIFM
Sequence: MSLNFLEFEKPIAELEAKVEALREISRRGDENALDLEKEIKQLEDKCLELKKKTFSDLGAWEVAQLARHPERPYVLDYIEHMFTEFDELAGDRAFADDKALVGGIARLDGRPVMVIGHQKGRGTKEKVIRNFGMPKPEGYRKAKRLMQMAERFNMPVITFIDTAGAYPGVGAEERGQSEAIAMNLKIMSELSVPVICNVVGEGGSGGALAIGVGDYVNMLQYSTYSVISPEGCASILWRDSDKAPQAAEAMGLVAPRLKELELIDTIIDEPLGGAHRDHKATAENIKQRLLEQLKELDAFDNEALLERRYQRLMSYGYC
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AQP11_HORSE
Sequence: MTALRALWSEMQDTCTSLGLMLSVVLLAGLARVVARQQQLHRPMAHAFVLEFLATLQLCCCTHELLLLSEQEPAHPTWPLTLIYFFTLVHGLTLVGTSSNPCGVMMQMMLGGMSPEMGAVRLLAQLIGALGSRYCIGALWSLGLTKYHVSERSFACKNPIQVDLPKAVIVEALCSFIFHSALLNFQEVRPKLRIHLLAALITFLVYAGGSLTGAVFNPALALSLHFKCFDEAFLQFFIVYWLAPSLGILLMILMFSFFLPWLYNNHTINKKE
What is the function of this protein?
Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain.  In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity).  Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER.  Plays a role in the proximal tubule function by regulating its endosomal acidification.  May play a role in postnatal kidney development (By similarity).
What are the official names of this protein?
Aquaporin-11.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes mainly to the periphery of lipid droplets. it accumulates partly in mitochondrial-associated endoplasmic reticulum membranes.
Protein: SUCC_AZOVD
Sequence: MNLHEYQGKQLFAEYGLPVSRGVAIDTPEAAAEACDRIGGDCWVAKVQVHAGGRGKAGGVKLVKSREEAKVFAVNWLGKRLVTYQTDASGQPVGKILVEACTEIERELYLGAVVDRSSRRIVFMASTEGGVNIEQVAHETPEKILKASIDPLVGAQPFQARDLAFRLGLEGDQLKQFTHIFIGLAKLFQEHDLALVEVNPLVVQKDGNLLCLDAKINLDTNALFRQPRLRAMHDPSQDDPREVHAAKWELNYVALEGNIGCMVNGAGLAMGTMDIVNLHGGRPANFLDVGGGATKERVTEAFKIILSDAKVKAVLVNIFGGIVRCDMIAEGIIGAVREVGVKVPVVVRLEGNNAELGAEMLARSGLNIIPASTLTDAAVQVVKAAEDNP
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: ARMX1_MOUSE
Sequence: MGRTREAGCVAAGMVIGAGACYCVYRLTWGKDENEKLWDEEEEEEEEEEEKSCSDKTEKELKTNVGVGARGKPQDDSKSKVEVNVGPENGPGVKKEVHPESQSGGGLEAKAKALFKTLKEQARAKAGRGIRLPNISRNRTLTSSLPCPGGRGGGCHPGRTGSRARNRTSGKVKRKNRSKSNKAPATAWPVRKGKFSFPYKIDDILSAPDLQKVLNILERTNDPFTQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTRDPIIREKTYNALNNLSVNSENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDFFALLFLGNHFTKIQTMKLIINFTENPAMTRELVSCKVPSELISLFNKEWDREILLNILTLFENINDNIKSEGLASSRKEFSRSSLFFLFKESGVCVKKIKALASHKDLVVKVKVLKVLTKL
What is the function of this protein?
Regulates mitochondrial transport during axon regeneration.  Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool.  Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons.  Promotes neuronal survival and axon regeneration after nerve injury.  May link mitochondria to the Trak1-kinesin motor complex via its interaction with Miro1.
What are the official names of this protein?
Armadillo repeat-containing X-linked protein 1.
What is the protein family that this protein belongs to?
Belongs to the eutherian X-chromosome-specific Armcx family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein.
Protein: WTR2_ARATH
Sequence: MAKSDMLPFLAMVLVQIGYAGMNITSKMAMEAGMKPLILVAYRQIFATIATFPVAFFLERKTRPKITLRILVQVFFCSITGATGNQVLYFVGLQNSSPTIACALTNLLPAVTFLLAAIFRQETVGIKKASGQAKVIGTLVCVIGAMVLSFYHGHTIGIGESKIHWAYAENITKHGSSSGHSNFFLGPFLIMAAAVSWAAWFIIQTKMSETFAAPYTSTLLMCLMGSIQCGAIALISDHTISDWSLSSPLRFISALYAGVVASALAFCLMSWAMQRKGPLYVSVFSPLLLVVVAIFSWALLEEKLYTGTFMGSALVVIGLYGVLWGKDREVSEKEEEREKVKQQNHKVKSESNEDIESRLPVASSGNGSTRSTSP
What are the official names of this protein?
WAT1-related protein At1g09380.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BUK_GEOSE
Sequence: MQEQKFRILTINPGSTSTKIGVFENERAIVEKTIRHEGRCFGNIKR
What are the official names of this protein?
Probable butyrate kinase, BK, Branched-chain carboxylic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT1_PNECA
Sequence: MEDEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPALLTEAPLNPKSNREKMTQIMFETFNTPAFYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLNLAGRDLTDYLMKILTERGYNYTTTAEREIVRDIKERLCYVALDFEQEIHTASSSSSLEKSYELPDGQVITIGNERFRAPEALFQPSIVGMETCGIHETTFNSIMKCDVDIRKDLYSNIVMSGGTTMYPGIADRMQKEITALAPSSMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDENGPSIVYRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin-1, Actin I.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: BTAF1_ASPFC
Sequence: MTSRLLETGSTPFIRNTAAQQLADVQKQHPDELFNLLGRILPYLRSKSWDTRAAAAKAIGLIVANADTFDPNQDDGQEIKKAENDDLDVDIKSEEELLSPMDDSLLQLERLDLPSILKYGKRLLGSAGKEYEYSLAAMDPASRLQHQKKTLTSRLGLAGEYIEEDLINDNDLVSKPVVKEEPSFVASREHSIQGTSQPLASPIEPANGEESGLSKRQLNQLKRKNKQSARMGANKVRVVDLSSRRASENVTTPSVATPYPIKSENGEERNGDSKPDYFSLDRSAGDDESKIVSEFKGASVPENPLLQPESTEEGPNPNWPFELMCDILMVDLFDPNWEIRHGAAMALREVIRIQGAGAGRVQGKSRAENDILNRKWLDDLACRLLCVLMLDRFGDYISDNVVAPIRETVGQTLGALLSQLPSRSVISVYKCLYRIIMQTDLGLERPIWEVCHGGMIGLRYLVAVRKDLLIKDSKLMDGVLEAVMKGLGDYDDDVRAVSAATLVPIAEEFVKTRQSTLGTLMTIVWDCLSNLQDDLSASTGSVMDLLAKLCTFQEVLDAMKANAAVNPESSFGKLVPRLYPFLRHTITSVRSAVLRALMTFLQLEGEGTDEWVDGKTVRLIFQNLLVERNEGVLKQSLQVWSELLNSLETRGSFKSESDLLSHIKPLITLSMGPFGVPRYPVPMDASLFIKPSGLPFPSSAAAPARSSPASNTPEGTKGRRRKSEKKEAPPPSAHNVDGHMLQGDIDLVGADTMLRSKIYAARALGQLLFVWDQNQLPSLWQSILEGLNHSASTSQLASAMIVEEYAKLSGPSGRYASTLCENLRPIIEGERPPWYSDIACYLHVARAQCHSLLNTFRDHAHVPGSRLPVLAVIVQGDPEAGPNAFSLSDAEKVIGPDFERLKKGLTPAQRITALQVLNDTRATAESAVNEARNVREQRDLRVRAAAAGALVALSDIPKKPSHIIKGMMDSIKKEENAELQQRSATAITSLVEYYTTSAKRGPVDKVIGNLVKYCCVDTSETPEFHHNAMLEKSILSLRKEEDRRDHPDAAKFEREAKEARIMRRGAKEALEQLAVKFGSELMAKVPNLASLIERPLKEALAADELPANIRDPENELGQEVVDGLSTLRAILPKFHSGLYPWVVDLLPLVVKALQCKLSVIRYAAAKCFATICSVITVEGMTMLVEKVLPMINDALDVHHRQGAVECIYHLIHVMEDGILPYVIFLVVPVLGRMSDSDNEVRLLATTSFATLVKLVPLEAGIPDPPGLSEELLKGRDRERQFMAQMLDVRKVEEFKIPVAIKAELRPYQQEGVNWLAFLNRYNLHGILCDDMGLGKTLQTICIVASDHHMRAEEFARTQKPEVRKLPSLIVCPPSLSGHWQQELKQYAPFLNCVAYVGPPAERSRLQSALPNADIVVTSYDICRNDNEVLNPINWNYCVLDEGHLIKNPKAKATIAVKRLLSNHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKVFLDRFAKPIAASRFSKSSSKEQEAGALAIEALHKQVLPFLLRRLKEEVLNDLPPKIIQNYYCDPSELQRKLFEDFTKKEQKALQDKVGSTEKADKEHIFQALQYMRRLCNSPALVVKEGHKQYNEVQQYLAAKHSNIRDVAHAPKLSALRDLLIDCGIGVDSPSEGDLSGASYVSPHRALIFCQMKEMLDIVQSEVFNKLLPSVQFLRLDGSVEATRRQDIVNRFNTDPSYDVLLLTTSVGGLGLNLTGADTVIFVEHDWNPQKDIQAMDRAHRIGQKKVVNVYRLITRGTLEEKILNLQRFKIDVASTVVNQQNAGLGTMDTDQLLDLFNLGETAETAEKPSDAAGNEVDMVDIDGNVKEKGKKGWLDDLGELWDDRQYQEEYNLDSFLATMKG
What is the function of this protein?
Regulates transcription in association with TATA binding protein (TBP).  Removes TBP from the TATA box via its C-terminal ATPase activity.  Both transcription activation and repression require its ATPase activity (By similarity).  Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B (PubMed:31969561).  The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter (PubMed:31969561).
What are the official names of this protein?
TATA-binding protein-associated factor mot1, TBP-associated factor mot1, Modifier of transcription 1, NCT transcriptional regulatory complex subunit mot1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
Protein: UBB_BOVIN
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC
What is the function of this protein?
Exists either covalently attached to another protein, or free (unanchored) (By similarity).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains) (PubMed:26116755).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B (By similarity).  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling (By similarity).  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed (By similarity).  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin-B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: NSP4_ROTPY
Sequence: MDKLADLNYTLSVITLMNDTLHSIIQDPGMAYFPYIASVLTVLFALHKASIPTMKIALKTSKCSYKVIKYCMVTIINTLLKLAGYKEQVTTKDEIEQQMDRIVKEMRRQPRMIDKLTTREIEQVELLKRIHDKLVTRPVDVIDMSKEFNQKNIKTLDEWESGKNPYEPSEVTASM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.