PharMolix/UniProtQA huggingface dataset:
Protein: MDH_CHLT3
Sequence: MKITVIGAGNVGATATQRIVEKQLAREVVLVDVVDGVPQGKALDMYESAPVELFDTRVVGTTGYEETAGSDIILITAGRPRKPGMSRDDLLAMNTEIVKTVTEEAVSKSPNAIIIVVSNPLDVMTYVAYVRSGFPKERVIGMAGVLDTARFRTFIAMELNVSVQDVNAFVLGGHGDSMVPVVKYTTVAGIPISELLPQDRIAALVDRARKGGIEIVNYLKTGSAYYAPSASAVEMIDAIVNDRKRIMPCSAYVTGQYGLNDVFVGVPVKLGRGGVEQVLEINLDEADRNALQASANEVKESCEKVNSMMQ
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: MIC27_LACTC
Sequence: MSRNFYADEGAFVGSSKGPLLPDILHTEDVSTKTLPTGNQIYDSKALDSWFSGIRKYVTHKYYIYKTELDTQKSAAANEWKSVQDYVSQHVLTDDYEKQELLVPSSALALGAFFTGRVLSNRRNWGFDSPLNTTKAGILTRNPSALGRVLTSIPSRVLLPWVLTGTVLSQLTPVTWNNSVKALEQDVLPADLVARYHEIWNQLLVDGVQKTSASVHRNVDASLQQGIGEVRRYLVKKLDL
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
What are the official names of this protein?
MICOS complex subunit MIC27.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS25_ICTPU
Sequence: MPPKDSKQKKDTSKAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLYKEVPNYKLITPAVVSERLKIRGSLARAALLELLSKGMIKLVSKHRAQVIYTRNTKGTDEGAPEKEA
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S25.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS25 family.
Protein: AURD_CALAK
Sequence: MPQSTKYILPVYGILALYSLGYFSYRNGYVNIVLEERQAWLDMPPGDPTKVAQPTGIASLDETLAAMFVFYWPVLDGSFPGLSLMFCNYLGALPLCLVLMTLESLRKGNRSSFSFFYSPTFWGMIAVMMTLAVSIPWYLTIHLLISTTASHPTIENMSIPLAELKALIVNIVVGLVLPSLLVALPETITQTLFTRQTAITLWQLWPFWSTAVHFIARKFISATERGADSRAQWTRVRSAFRSVYGLTFAAAAIAHIATWSISLTAAYALPDAMSAETVSSLHPQTVFVNTWPWLPVTTDSVGEGTLWLLQWDKFVGVGAIYWWSLDLYRAAHTAQRKKINWYYFALKTVAFCLVSGFTGATIELLWEREEMIMEAGRAKEKTK
What is the function of this protein?
Epoxide hydrolase; part of the gene cluster that mediates the biosynthesis of aurovertins, fungal polyketides that exhibit potent inhibition of adenosine triphosphate synthase (PubMed:26340065).  Tha biosynthesis starts with the HR-PKS aurA that selects propionate as the starter unit; synthesizes a hexa-ene chain through the repeated functions of the KR and DH domains in the first six iterations; selectively introduces three alpha-methyl substitutions at C4, C6, and C16 using the S-adensylmethionine-dependent cMET; and shuts off KR and DH in the last three iterations to afford a 1,3,5-triketo portion that can undergo intramolecular cyclization to yield the alpha-pyrone intermediate (PubMed:26340065).  AurE may act as a cyclase and enhances the rate of pyrone formation and product release of aurA (PubMed:26340065).  The methyltransferase aurB then methylates the C17 hydroxyl group (PubMed:26340065).  C17 methylation is required to initiate epoxidation by the downstream monooxygenase aurC (PubMed:26340065).  The monooxygenase aurC and the epoxide hydrolase aurD can iteratively transform the terminal triene portion of the methylated precursor into the dioxabicyclo[3. 2. 1]octane scaffold of aurovertin E.  Epoxidation modifications of the precursor occur in two separate steps; bis-epoxidation of the two terminal olefins takes place first, followed by another epoxidation that occurs at C7-C8 after tetrahydrofuran formation (PubMed:26340065).  The O-acyltransferase aurG converts aurovertin E to aurovertin A (PubMed:26340065).
What are the official names of this protein?
Terpene cyclase aurD, Aurovertin biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound ascI terpene cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LEPA_BARQU
Sequence: MTVDRNYIRNFSIVAHIDHGKSTLADRLIQMTGGLETREMKEQVLDSMDIERERGITIKAQTVRLHYKAKNGETYILNLIDTPGHVDFAYEVSRSLAACEGSLLVVDASQGVEAQTLANVYQAIDNSHELVVVLNKVDLPAAEPERVKEQIEDVIGIDTSEAVEISAKTGFGVPDVLEAIVRQLPPPHIGDVKNPLKVMLVDSWYDAYLGVIVLVRVIDGILKKGQIIRMMGTGVKYLVERVGVFTPKMVQVDTLGPGEIGFITASIKEVADTRVGDTITEERRPCENALPGFKPAQPVVFCGIFPIDAADFDGLRAAMGKLRLNDASFSFEMETSAALGFGFRCGFLGLLHLEIIQERLEREFNLDLIATAPSVVYRMNMNNGSVKELHNPADMPDLVKVSSIEEPWIRATIMTPDDYLGAILELCQERRGIQVGLSYVGTRAMVTYNLPLNEVVFDFYDRLKSISKGYASFDYQMTDYSEGDLVKMSILVNGESIDALSMLVHRTVAEKRGRSMCEKLKDLIPQHMFQIPIQAAIGGKIIARETIRALRKDVTAKCYGGDVTRKRKLLEKQKEGKKRMRQFGKVEIPQSAFIEALKMSK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NSF1C_CHICK
Sequence: MADREEALREFVAVTGAEEERARFFLESAGWDLQIALASFYEDGGDEDILTLPQPTPSSVSRGTAASDHRVTSFRDLVHAQEDDDEEEEGQRFYAGGSERSGQQIVGPPRKKSPNELVEDLFKGAKEHGAVAVDRTAKSSGESSKPKPFAGGGYRLGATPEEESAYVAGERRHNSVQDVHVVLKLWKTGFSLDSGELRSYQDPSNAQFLDDIRRGEVPAELRRLARGGQVNLDMEDHRDEEYVKPKSVFKAFTGEGQKLGSTAPQVLSTSSPAQQAENEAKASSAIAIDESEPVTNIQIRLADGGRLVQKFNHNHRIRDIRLFIVDARPAMAATSFVLMTTFPNKELTDENQTLKEANLLNAVIVQRLT
What is the function of this protein?
Reduces the ATPase activity of VCP.  Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis.  May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER).  Inhibits the activity of CTSL (in vitro).  Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase.  Also, regulates spindle orientation during mitosis.
What are the official names of this protein?
NSFL1 cofactor p47, p97 cofactor p47.
What is the protein family that this protein belongs to?
Belongs to the NSFL1C family.
What are the subcellular locations of this protein?
Nucleus. Golgi apparatus, Golgi stack. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear in interphase cells. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.
Protein: MENC_SHIDS
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQETWEEAQSVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELTDTLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRDRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLEKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSTLPVVEVDALERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: HGL1C_WHEAT
Sequence: MALLAAATLNPTTHLSIRSRAGHNSENLWLRSAASSQKSKGRFCNLTVRAGTPSKPAEPIGPVFTKLKPWQIPKRDWFDKDFLFGASTSAYQIEGAWNEDGKGPSTWDHFCHTYPERISDRTNGDVAANSYHLYEEDVKALKDMGMKVYRFSISWSRILPNGTGKPNQKGIDYYNNLINSLIHHGIVPYVTIWHWDTPQALEDKYGGFLNRQIVNDYKHFAKVCFESFGDRVKNWFTFNEPHTYCCFSYGEGIHAPGRCSPGMDCAVPEGDSLREPYTAGHHILLAHAEAVELFKAHYNEHGDSKIGMAFDVMGYEPYQDSFLDDQARERSIDYNLGWFLEPVVRGDYPFSMRSLIGDRLPMFTKEEQEKLASSCDIMGLNYYTSRFSKHVDISSDFTPKLNTDDAYASSETKGSDGNDIGPITGTYWIYMYPKGLTDLLLIMKEKYGNPPIFITENGIADVDSDPTMTDPLDDWKRLDYLQRHISAVKDAIDQGADVRGHFTWGLIDNFEWSLGYSSRFGLVYIDKKDGNKRKLKKSAKWFAKFNSVPKALLKTTNTNNKPAVTASVSL
What is the function of this protein?
Acts in defense of young plant parts against pests via the production of hydroxamic acids from hydroxamic acid glucosides.  Enzymatic activity is highly correlated with plant growth.  The preferred substrate is DIMBOA-beta-D-glucoside.
What are the official names of this protein?
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1c, chloroplastic, Beta-glucosidase 1c, Taglu1c.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL18_TRIEI
Sequence: MKYTRKDSIIKRHRRVRKKVFGTSERPRLSVFRSNMHIYAQVIDDTKQHTLVAASTLEAEVKSTIKSGANCDASIQIGKLIAQRSLEKGIEKVVFDRGGNLYHGRVKALAEAAREAGLDF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: KAD_TRYBR
Sequence: MAVLSEDVLLYLKEKNIPMLFEQIVQNIISDAPERPMSYIGDLMRRGIPLQIFIAGPAGSGKRTQCKNIADRLGVVLISSGQVLTRGVESGSETSQLAHSYVSRGERVPDTLVSMIMKDRLSQSDACEKGWLVEGYPRNAQQAQAVEECGVIPQVFILLDLPEDLSFRRLEHRRYDPATNKXYHMLDNPPPGGRCRVMRTAPAEGCKFP
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SGPP2_HUMAN
Sequence: MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEAYVQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP
What is the function of this protein?
Has specific phosphohydrolase activity towards sphingoid base 1-phosphates.  Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432).  Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity).  May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling.  May play a role in pro-inflammatory signaling (PubMed:17113265).  Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity).
What are the official names of this protein?
Sphingosine-1-phosphate phosphatase 2, SPPase2, Spp2, hSPP2, Sphingosine-1-phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the type 2 lipid phosphate phosphatase family.
Protein: DNAT_ECOSE
Sequence: MSSRVLTPDVVGIDALVHDHQTVLAKAEGGVVAVFANNAPAFYAVTPARLAELLALEEKLARPGSDVALDDQLYQEPQAAPVAVPMGKFAMYPDWQPDADFIRLAALWGVALREPVTTEELTSFIAYWQAEGKVFHHVQWQQKLARSLQIGRASNGGLPKRDVNTVSEPDSQIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: RP147_VACCA
Sequence: MAVISKVTYSLYDQKEINATDIIISHVKNDDDIGTVKDGRLGAMDGALCKTCGKTELECFGHWGKVSIYKTHIVKPEFISEIIRLLNYICIHCGLLRSREPYSDDINLKELSGHALRRLKDKILSKKKSCWNSECMQPYQKITFSKKKVCFVNKLDDINVPNSLIYQKLISIHEKFWPLLEIHQYPANLFYTDYFPIPPLIIRPAISFWIDSIPKETNELTYLLGMIVKNCNLNADEQVIQKAVIEYDDIKIISNNTSSINLSYITSGKNNMIRSYIVARRKDQTARSVIGPSTSITVNEVGMPAYIRNTLTEKIFVNAFTVDKVKQLLASNQVKFYFNKRLNQLTRIRQGKFIKNKIHLLPGDWVEVAVQEYTSIIFGRQPSLHRYNVIASSIRATEGDTIKISPGIVNSQNADFDGDEEWMILEQNPKAVIEQSILMYPTTLLKHDIHGAPVYGSIQDEIVAAYSLFRIQDLCLDEVLNILGKYGREFDPKGKCKFSGKDIYTYLIGEKINYPGLLKDGEIIANDVDSNFVVAMRHLSLAGLLSDHKSNVEGINFIIKSSYVFKRYLSIYGFGVTFKDLRPNSTFTNKLEAINVEKIELIKEAYAKYLNDVRDGKIVPLSKALEADYVESMLSNLTNLNIREIEEHMRQTLIDDPDNNLLKMAKAGYKVNPTELMYILGTYGQQRIDGEPAETRVLGRVLPYYLPDSKDPEGRGYILNSLTKGLTGSQYYFSMLVARSQSTDIVCETSRTGTLARKIIKKMEDMVVDGYGQVVIGNTLIKYAANYTKILGSVCKPVDLIYPDESMTWYLEISALWNKIKQGFVYSQKQKLAKKTLAPFNFLVFVKPTTEDNAIKVKDLYDMIHNVIDDVREKYFFTVSNIDFMEYIFLTHLNPSRIRITKETAITIFEKFYEKLNYTLGGGTPIGIISAQVLSEKFTQQALSSFHTTEKSGAVKQKLGFNEFNNLTNLSKNKTEIITLVSDDISKLQSVKINFEFVCLGELNPNITLRKETDRYVVDIIVNRLYIKRAEITELVVEYMIERFISFSVIVKEWGMETFIEDEDNIRFTVYLNFVEPEELNLSKFMMVLPGAANKGKISKFKIPISDYTGYDDFNQTKKLNKMTVELMNLKELGSFDLENVNVYPGVWNTYDIFGIEAAREYLCEAMLNTYGEGFDYLYQPCDLLASLLCASYEPESVNKFKFGAASTLKRATFGDNKALLNAALHKKSEPINDNSSCHFFSKVPNIGTGYYKYFIDLGLLMRMERKLSDKISSQKIKEMEETEDF
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:31835031).  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 147 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 147 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.
Protein: NADD_STRP8
Sequence: MALELLTPFTKVELEEEKKESNRKQIGILGGNFNPIHNAHLVVADQVRQQLGLDQVLLMPECKPPHVDAKETIDEKHRLCMLELAIEDVEGLAIETCELERQGISYTYDTMIYLTEQHPDVDYYFIIGADMVDYLPKWHRIDELVKLVQFVGVQRPKYKAGTSYPVIWVDLPLMDISSSMIRDFIKKGRQPNYLLPKQVLDYITQEGLYQ
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: TRM4_METJA
Sequence: MMIVYKGEKMQFIRVNTLKINPEVLKKRLENKGVVLEKTFLDYAFEVKKSPFSIGSTPEYLFGYYMPQSISSMIPPIVLNPREDDFILDMCAAPGGKTTHLAQLMKNKGTIVAVEISKTRTKALKSNINRMGVLNTIIINADMRKYKDYLLKNEIFFDKILLDAPCSGNIIKDKNRNVSEEDIKYCSLRQKELIDIGIDLLKKDGELVYSTCSMEVEENEEVIKYILQKRNDVELIIIKANEFKGINIKEGYIKGTLRVFPPNEPFFIAKLRKI
What is the function of this protein?
Catalyzes AdoMet-dependent formation of m5C in tRNA.  Cytidine residue at either position 40 or position 48 is likely to be methylated.
What are the official names of this protein?
tRNA (cytosine(48)-C(5))-methyltransferase, aTrm4, tRNA (cytosine-5-)-methyltransferase Trm4.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRX7_PENRW
Sequence: MGLAVAKALSLQKDWEIYILDINSERGAETAKELPRTTFHYANVTKYSDLAAAFQSMFQQHGKLDFVFANAGVIERTNFYSTPQAENDMDVCPPPEPDLPSIDADLKGVVFTAYLAQHYFRHSPHRGHGGSLVMTASCGGLYPSFYSPLYSAAKFGVVGFMRSISQHFHASGIRVNAICPGIVRTNLVDSAGWDSFPPGRFIEVETIARLVLQLVDGGEPAGRGLTDTTGRHLPLEELYGVAVEISDSGFYFRDQHTFCDEGMREVMDATVVENQVGAVLNG
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase prx9 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699) (By similarity).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase prx11 (By similarity).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:24239699).  The cytochrome P450 monooxygenase prx8 also plays a role in this step (By similarity).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:24239699).
What are the official names of this protein?
Short-chain dehydrogenase/reductase prx7, PR-toxin biosynthesis cluster protein 7.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RIMM_SHIDS
Sequence: MVMMSKQLTAQAPVDPIVLGKMGSSYGIRGWLRVFSSTEDAESIFDYQPWFIQKAGQWQQVQLESWKHHNQDMIIKLKGVDDRDAANLLTNCEIVVDSSQLPQLEEGDYYWKDLMGCQVVTTEGYDLGKVVDMMETGSNDVLVIKANLKDAFGIKERLVPFLDGQVIKKVDLTTRSIEVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2495_CLOTE
Sequence: MRFVIVTGLSGAGKTQAIRSLEDLGYFCVDNLPPTLIPKFAEACYKTDGRINKIALVIDIRGGEFFDNLFESLNYIKDQNYKYEILFLEASDEVLVKRFKETRRNHPLSSGGRILNGIALERSRLKEVKDVASNIINTSKFTNMDLRQEITRIYGDGDQVEAQLTITVVSFGFKYGIPLDSDLLFDVRFLPNPYYIPELRNFSGNDKPVYDYVLEFNQTKEFIGKLNDILEFLIPHYTEEGKRQLIVAIGCTGGRHRSVSIANSIYKLLEEKGHKVNIDHRDIHEDNNKGGKKL
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein CTC_02495.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: GON3_ONCKE
Sequence: QHWSYGWLPG
What is the function of this protein?
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
What are the official names of this protein?
Gonadoliberin-3, Gonadoliberin III, Gonadotropin-releasing hormone III, GnRH-III, Luliberin III, Luteinizing hormone-releasing hormone III, LH-RH III.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM_BACC3
Sequence: MSIFIGGAWPYANGSLHLGHIASLLPGDILARYYRAKGENVLYVSGSDCNGTPIAIRAKQEGVTAKEIANKYHEEFERCFRNLGFTYDCYTRTDSEHHHETVQNVFLRLLEEGHIYKKTVEQAYCETCTQFLPDRYVEGVCPHCHEEARGDQCDACSAILDPLDLLEKKCKLCGSTPSIQETEHFYFALHTFQEQIKRAVEIAKQTGTWRDNAIQLTERYVKEGLLDRAVSRDLPIGVPIPVEGYEDKKIYVWIEAVTGYYSASKHWAEETGKDDREFWDSEAKTYYVHGKDNIPFHSVIWPAVLLGIGEGAIPRHIVSNEYLTVEKRKLSTSKNWAVWVPDILERYDPDSIRYFLTVNAPENRDTDFSWREFIYSHNSELLGAYGNFVNRTLKFIEKYYGGIMPKGSIDVELKDKIERLYKHVGEAIEQTKFKVALESIFDAVRFANKYFDERQPWKEREDDPVSCEETIYNCVYLIANFANLLEPFLPFSSERIRNTLSIVNRNWEPQHTLPTRIDSVKPLFERIDVKQIERELEKLYGAVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBPM_PSEP1
Sequence: MSSTLIVQLDMRTLCQEADVTAECVIEIVEHGIVEPSGRTPEDWLFDDQAPLVTKRAVKLHQELELEWEGVALALELLQEVQQLRSENNMLKQRLGRFIQM
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: CYB_OXYIH
Sequence: MTIMRKNHPLLKIINHSFIDLPTPSNISSWWNFGSLLGICLMIQILTGLFLAMHYTSDTATAFSSVAHICRDVNYGWLIRYLHANGASMFFICLFIHVGRGIYYGSYMLSETWNIGIILFLTTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGNTLVEWIWGGFSVDKATLNRFFAFHFILPFIIAAFALVHLLFLHETGSNNPSGLNSDSDKIPFHPYYTIKDLLGILLLLMILMILVLFFPDILGDPDNFTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILATFPLLNSSKQHGLIYRPITQVLFWVFIANLLILTWIGGQPVEYPFTTIGQIASILYFTIIIILMPIANMIENNILKLH
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.