PharMolix/UniProtQA huggingface dataset:
Protein: ATPB_SCHGA
Sequence: VLIMELINNVAKAHGGYTVFAGVGERTREGNDLYHEMIESGVISLKDKTSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTSKGSITSVQAIYVPADDLTDPA
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Protein: MDH_HAES1
Sequence: MKIAVLGAAGGIGQALALLLKLQLPAGSELSLYDIAPVTPGVAADVSHIPTAVKIQGFAGEDPTPALENADVVLISAGVARKPGMDRSDLFNINAGIVKNLIEKVAKTCPKACVGIITNPVNTTVAIAAEVLKKAGVYDKRKLFGVTTLDVLRSETFVAELKGLNVSRIAVPVIGGHSGVTILPLLSQVQYAEWEEDEIAPLTKRIQNAGTEVVEAKAGGGSATLSMAQAAARFALSLVQGLSGETVVECTYVEGDGKYARFFAQPVRLGKEGVEEILPVGTLSAFEQKALEDMLPTLRADIELGEKFVNN
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: AROC_PORGI
Sequence: MNTIGKLFRLTTFGESHGKAIGGVIDGCPAGLFVDMETIERELLRRRPGQSHYTSPRQESDMVQFISGLFRGETTGAPIAFMIDNKDVRSADYDSLSSIFRPGHADYTYFHKYGIRDTRGGGRSSARETAVRVVAGAVAKQLLAPLGIRCTAYTSQIGPVCIPQENAKEYSPEEVESSPIRCPDPNASGLMEAVIETAKKESDSVGGIVDCQISDVPVGWGEPLYGKLHAALGAAMLSINAAKGFEVGDGFALASMRGSEANDQMVAAEDGGISFLSNHSGGISGGISTGQDIRFRVAFKPTPTIGQKQQTVNEQGESISLSAVGRHDPCVVPRAVPVVEAMTWLTLADAYLASRSGRCAHSSLKCNG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: UPP_CLOBH
Sequence: MSKVTQIAHPLILHKLALIRDKNTGSKDFRELVEEVAMLMAYEVTRDLQLKEVEIETPICKTKCKMLSGKKVAIVPILRAGLGMVGGMTSLIPAAKVGHIGLYRDEETLKPVEYFCKLPQDIGDRDVIVTDPMLATGGSAKDAITLLKQKGAKHIRLMCLVAAPEGIKEVMDEHPDVDIYVASVDEKLNEKGYVVPGLGDAGDRLYGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: AUSL_PENBI
Sequence: MEEPLTVAAIFRGPFNILAISEVLKVVAAVGWSVNYIGMVHRAWKDQIPSIGILPLCCDIGWEFVYAWMFPDFSSHWQGVVRVWFFLHSAVLLVTLKVSPNDWANTPLAHRHIVFIYIFVTIVFGAGQYALAAEIGPALGFHWGGALCQFLSSSGGIAQLLSRGHTRGASYLIWFARAISTFAGFIKLCIRFQHNVDGAPWLDSPMCWFYIVTVLSFDAAYPFLYFSMRKFETPAPQREARIKKQ
What is the function of this protein?
Terpene cyclase; part of the gene cluster A that mediates the biosynthesis of the fungal meroterpenoid acetoxydehydroaustin (PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (By similarity).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (By similarity).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG then modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:29076725).  The cytochrome P450 monooxygenase then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:29076725).  The hydroxylation catalyzed by ausR permits the second O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:29076725).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end product of the Penicillium brasilianum austinoid biosynthesis clusters is acetoxydehydroaustin (PubMed:29076725).
What are the official names of this protein?
Terpene cyclase ausL, Austinoid biosynthesis clusters protein L.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y545_AQUAE
Sequence: MQMYTDGERVFISRNYRVEGISKKDWIEKGEKKVVWQSAKLSETPTLLTNTRFYLFGAGATYLMRMDRRSGQTEEIDFEKEIVDITSDLRDVYFITHEGIYKLDAERFEKAKIERLAVSDILEKPIKTLDMIEDYLYVCAGNWLYKIRKDGEKVMEKALVDVRKVLADYEGPVVITEDKVIYFTDELDTLANGFYEGEYIKAEHGAYQTYLLSSTHFSVFGRTGERIAHVEYEHYRTFTEGLNHIYYYDEKEGDITYAFKRDLLGDDFINIDLVDTIALIFASLMAVEKAGHRVRIKEKRGFIDVDVNHKHVDMEKIFLTLSKYFPEIFYLYKNPGYYDEIDNFAQNYDLFIKEGDQVKLNLDLLEKFSEIRQDFKTLQEDIVRDILPSRADFFQSSTM
What are the official names of this protein?
Uncharacterized protein aq_545.
Protein: SERC_CAMJD
Sequence: MRKINFSAGPSTLPLEILEQAQKEFCDYQGKGYSIMEISHRTKVFEEVHFGAQEKAKKLYGLNDDYEVLFLQGGASLQFAMIPMNLALNGVCEYVNTGVWTKKAIKEAQILGVNVKIVVSSEESNFDHIPRVEFSDNADYAYICSNNTIYGTQYQNYPKTKAPLIVDASSDFFSRKVDFSNIALFYGGVQKNAGISGLSCIFIRKDMLERSKNKQIPSMLNYLTHAENQSLFNTPPTFAIYMFNLEMDWLLNQGGLDKVHEKNSQKATMLYKCIDLSDGFYKGHADKKDRSLMNVSFNIAKNKDLEPLFVKEAEEAGMIGLKGHRILGGIRASIYNALNLDQVKILCEFMKEFQGKYA
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_FUSNN
Sequence: MCVDCKKRVRTRVAPSPTGDPHVGTAYIALFNIAFAHVNDGDFILRIEDTDRNRYTEGSEQMIFDALKWLDLDYSEGPDVGGDYGPYRQSERFDLYGKYAKELVEKGGAYYCFCDHERLENLRERQKAMGLPPGYDGHCRSLSKEEIEEKLKAGVPYVIRLKMPYEGETVIHDRLRGDVVFENSKIDDQVLLKADGYPTYHLANIVDDHLMGITHVIRAEEWIPSTPKHIQLYKAFGWEAPEFIHMPLLRNDDRSKISKRKNPVSLIWYKEEGYLKEGLVNFLGLMGYSYGDGQEIFTLQEFKDNFNIDKVTLGGPVFDLVKLGWVNNQHMKMKDLGELTRLTIPFFVNEGYLTNENVSEKEFETLKKVVGIEREGAKTLQELAKNSKFFFVDEFSLPELREDMDKKERKSVERLLNSLKDEIGLKSIKLFIEKLEKWNGNEFTAEQAKDLLHSLLDDLQEGPGKIFMPIRAVLTGESKGADLYNILYVIGKERALKRIKNIVKKYNIGI
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_BIFA0
Sequence: MYAIVKAGGHQEKVEVGDTILVNRLDAKNGETVEFPVALVVDGEKVIIAAADLAKISVKAEVVNDDAKGPKIRIQKFKNKTGVARRKGHRQKLTQLKITAIA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: SYL_YERP3
Sequence: MQEQYRPEDIETQVQLHWQEKQTFKVTEDASKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVISRYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIEYMKNQLKLLGFGYDWDREIATCKPDYYRWEQWFFTKLYEKGMVYKKTSAVNWCPHDLTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITDYAEQLLNDLDTLESWPEQVKTMQRNWIGRSEGVDIVFDVVDSEEKLSVYTTRPDTFMGVTYVAVAAGHPLSLQAAATNPALADFVAECRNTKVAEAEMATMEKKGMATGLYAIHPLTGEKLPIWAANFVLMDYGTGAVMAVPGHDARDWEFATKYNLPIKPVILAADGSEPDLSQEAMTEKGTLFNSGEFDGLNHEDGFNAIADKLVALGVGQRKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVVPTPEDQLPVILPEDVVMDGISSPIKADPEWAKTTVNGIPGLRETDTFDTFMESSWYYARYTCPQYDDGMLDPAAANYWLPVDQYVGGIEHAIMHLMYFRFFHKLLRDAGLVDSDEPAKRLLCQGMVLADAFYYTGNNGERIWVSPVDAIVERDDKGRIVKAVDAEGHELVYAGMSKMSKSKNNGIDPQVMVEKYGADTVRLFMMFASPAEMTLEWQESGVEGANRFLKRVWRLAFDHTAKGAVKPLDIASLTEEQKSLRRDLHKTIAKVTDDVGRRQTFNTAIAAVMELMNKLGRAPQETEQDRALMQEALLAVVRMLYPFTPHVCFSLWQALGGEGDIDTAPWPIADEQAMVEDSKLVVVQVNGKVRGRITVPADATEQQVRERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVVG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_RHOBA
Sequence: MTPTAASELLLSIESTCDETAAAVIRRDGTVLGQCIATQETLHEQFGGVVPEIAARAHLERILPVIDTALTQAKVRGEDLTAIAVADRPGLAGSLLVGVVAAKTLALAWNKPLISLNHLHAHLYACQLIEGAPANIYPAIGLIVSGGHTSLYVCRTAIDLEYLGGTIDDAAGEAFDKVAAMLSLPFPGGIEVAKLASQGNDKAYSFPRSMIHDPGDDFSFSGLKTAVRYAIVGPGRQDFASLDISDQVKRDVCASFEAAVVDVLVSKCRRAIKRHRNRNNDPQNSINRLIVGGGVAANQRLRRDLQAAADKDGFELWIAPPHLCTDNAVMGAIAWKKFEAEQFASLDLDITPGLQRGF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_ACIET
Sequence: MNKIRKGDEVIVLTGRDKGKRGTVSLRKDDSHLVIEGINLVKKHVKPNPMKGTTGGIVEKAMPIHQSNVAIFNAATGKADRVGIKVQADGTRVRVFKSSGAEIKAA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: NUOB_JANMA
Sequence: MAIEGVLNEGFVTTTADKLINWTRTGSMWPMTFGLACCAVEMMHAGASRYDLDRFGVVFRPSPRQSDVMIVAGTLCNKMAPALRKVYDQMAEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALLYGIMQLQNKIRRTNTIAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: XGPT_ECO57
Sequence: MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMGVVFVPPISGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EULS3_ARATH
Sequence: MEHHHQHHRHHQRDDGEDDRQSFGVPPPHVDAPPQPHGLYQSQPHFDPYAPTPQAPAPYRSETQFEPHAPPPYRSEPYFETPAPPPSFGHVSHVGHQSPNESYPPEHHRYGGYQQPSNSLLESHGDHSGVTHVAHHSSNQPQSSSGVYHKPDENRLPDNLAGLAGRATVKVYSKAEPNYNLTIRDGKVILAPADPSDEAQHWYKDEKYSTKVKDADGHPCFALVNKATGEAMKHSVGATHPVHLIRYVPDKLDESVLWTESKDFGDGYRTIRMVNNTRLNVDAYHGDSKSGGVRDGTTIVLWDWNKGDNQLWKIFPF
What is the function of this protein?
Lectin which binds carbohydrates in vitro.  Interacts through its lectin domain with glycan structures containing one or more Lewis X, Lewis Y or lactosamine motifs (PubMed:21945438).  May play a role in abiotic stress responses (Probable).  May play a role in abscisic acid-induced stomatal closure.  May play a role in disease resistance against Pseudomonas syringae through its involvement in stomatal movement (PubMed:26259197).
What are the official names of this protein?
Ricin B-like lectin EULS3, Euonymus lectin S3, AtEULS3.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CYF_ORYNI
Sequence: MENRNTFSWVKEQMTRSISVSIMIYVITRTSISNAYPIFAQQGYENPREATGRIVCANCHLANKPVDIEVPQAVLPDTVFEAVLRIPYDMQLKQVLANGKKGGLNVGAVLILPEGFELAPPDRISPELKEKIGNLSFQSYRPNKKNILVIGPVPGKKYSEIVFPILSPDPAMKKDVHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNATSTGVVRKILRKEKGGYEISIVDASDGRQVIDLIPPGPELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFFASVILAQVFLVLKKKQFEKVQLYEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CBF5_CANAL
Sequence: MSSKEDYIIKPESVSPSNDTSQWPLLLKNYDKLLVRSGHYTPIPAGSAPLNRDIKSYVSSGVINLDKPSNPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHEQLKDDKELNRALENLTGALFQRPPLISAVKRQLRVRTVYDSKLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGAMSESDNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLESLLVGYKRVVVKDSAVNSVCYGAKLMIPGLLRYEEGIELYDEVVLMTTKGEAIAIGIAQMSTVDLQSCDHGIVAKVKRCIMERDTYPRRWGLGPIAQKKKQMKADGKLDKYGRVNENTPENWKKDYKDLDEQPAPPIPESKLVAPEPQLPKKKSLIEEVEVDIDVEDKSEKKEKKDKKEKKEKKDKKEKKEKKDKKEKKRKAEDDSSKSEKKKKSKKD
What is the function of this protein?
Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing.  The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs.  Catalyzes pseudouridylation at position 93 in U2 snRNA.  Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit CBF5, Centromere-binding factor 5, H/ACA snoRNP protein CBF5, Small nucleolar RNP protein CBF5.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GLGB_PROMS
Sequence: MIETIQADWIKSEAINLENCCNDNPLKILGPHFYEEQWVIRVWMPEADEVKINFKNNTYKAESINHKWLFEAILPENPNHNYEINILRGGVTHTQHDPWSYREEWMGEVDRHLFAEGNHHHIWEKMGAHLIEEKNQKGVMFCIWAPNAKSISIIGDINSWDGRHHPMQKRLGGIWELFMPSMQEGDTYKYEIRTQQGHIYEKADPYGFLHEIRPQNGSIVSKLKNFNWNDSSWISNRDSSSQINKPISVYEMHLGSWLHESTDNKYLENNGDPRDPVPAADLKPGTRLLTYPELTKKLIPYVKERGFTHIELMPISEHPFDGSWGYQVTGWYAPTSRFGTPNEFREFVNKCHEEGIGVILDWVPGHFPKDKHGLAFFDGCHLYEHGDSRIGEHKEWGTLIFNYSRNEVRNFLVANLVYWFEEFHIDGIRVDAVASMLYRDYLRPDGEWIPNENGGNENIEAVKFLQQANHVLFQHFPGALSIAEESTTWPMVTKPTDMGGLGFNLKWNMGWMHDMLDYFEIDPWFRQFHQNSVTFSITYNYTENFMLALSHDEVVHGKSHLLHKMPGDDWKKYANTRALLTYMWTHPGKKTIFMGMEFGQRQEWNVWDDLQWELLEFEPHKGIRNLIDDLNVLYKNEPALWKNDFDPYGFQWIDCNDKSNSVISFMRRENDTNEWLVVVANFTPNTHESYKVGVPMEGFYREIFNSDGSRYGGSNKGNLGGKETINYNIHDYQNALELALPPLSVSIFKHQSKK
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: FTN_CAMJE
Sequence: MLSKEVVKLLNEQINKEMYAANLYLSMSSWCYENSLDGAGAFLFAHASEESDHAKKLITYLNETDSHVELQEVKQPEQNFKSLLDVFEKTYEHEQFITKSINTLVEHMLTHKDYSTFNFLQWYVSEQHEEEALFRGIVDKIKLIGEHGNGLYLADQYIKNIALSRKK
What is the function of this protein?
Iron-storage protein.
What are the official names of this protein?
Bacterial non-heme ferritin.
What is the protein family that this protein belongs to?
Belongs to the ferritin family. Prokaryotic subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFNG_SIGHI
Sequence: MNSRLCIMALLLCFSQALLGHFTVIEEIEKLKKYFNSSSSDVGDQKDIVSDILRNWQNDRDVKVIESQIVSFYLKLFEALKEHKTIQESINTIRADLIVNFFNNSREKMDDFIKLTTIPVNDLQVQRKAVNELVGVMHRLSSNIRRKKKGSRCCFGGGDRLNQNYPARSI
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: CMOA_COLP3
Sequence: MHDSDTDLIYSQAHNQVKNFTFDAQVVEVFPDMISRSVPGYKTIIDTIGRLSERFTQDDSNIYDLGCSLGAATLAMRKGITANNCKIIGVDNSIDMVKRCKMHVDAFKGDTPVTIIEGNIQDIDIENASMVVLNFTLQFIEKSQRQALLSKIAQGLKPGGLLVLSEKISSDDNVIDDVLINLHHNFKRDNGYSELEVAQKRSALEKVMLTDSLDVHKERLTQAGFQHVSLWFQCFNFTSLIAIK
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: TPMT_LEGPC
Sequence: MNKGQYFWNELWCEGRISFHKEEVNPDLIAYVSSLNTPAKGRILVPLCGKSVDMLWLVRQGYHVVGIELVEKAILQFVQEHQITVRENTIGQAKQYFTDNLNLWVTDIFALNSALIEPVDAIYDRAALVALPKKLRPAYVDICLKWLKPGGSILLKTLQYNQEKVQGPPYSVSSEEIALSYQQCAKIELLKSQKRIQEPNDHLFNLGISEVNDYVWCIRKG
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_ONYPE
Sequence: MKITIIGSGAWGSTLAQVLTDNNNQVLLYDINLSYVEKINQGKHPIFNAPLVNVKAVSCLKQALDYSDLIVLSVPMKFMRHLLKQIALMLTTPKSFVNVSKGIEPLTFLRVSEIVKQVIPAPLLANFASLMGPSHAEEVILRKLTLLTAASSNPAFALEIQKLFSCPNYLKVYTSSDLVGNEICSAFKNVLAFINGILVAKNFGINSQAALMSRGILEMSVLVTFYQGNPQTVLGLPGLGDLIVTAFSKYSRNFNAGAKIAAGITYQQIIDSSLQTIEGFQTLNAFYQLQLKHNLDLPIIQASYQLIFESKPFETVFATLMQRPFKSEF
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCHS_PSEFL
Sequence: MTLSPADQSKLEGFWQHCVTHQYFNIGYPESADFDYSQLHRFLQFSINNLLGTGNEYSNYLLNSFDFEKDVMTYFAELFNIALEDSWGYVTNGGTEGNMFGCYLGRELFPDGTLYYSKDTHYSVAKIVKLLRIKCRAVESLPNGEIDYDDLMAKITADQERHPIIFANIGTTMRGALDNIVTIQQRLQQAGIARHDYYLHADAALSGMILPFVDHPQPFSFADGIDSICVSGHKMIGSPIPCGIVVAKRNNVARISVEVDYIRAHDKTISGSRNGHTPLMMWAALRSYSWAEWRHRIKHSLDTAQYAVDRFQASGIDAWRNENSITVVFPCPSERIATKYCLATSGNSAHLITTPHHHDCSMIDALIDEVVAEAQLNTLRSKRAFTEQTVVERLPAASFNLRTHY
What are the official names of this protein?
Histidine decarboxylase, HDC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: FRDA_MOUSE
Sequence: MWAFGGRAAVGLLPRTASRASAWVGNPRWREPIVTCGRRGLHVTVNAGATRHAHLNLHYLQILNIKKQSVCVVHLRNLGTLDNPSSLDETAYERLAEETLDSLAEFFEDLADKPYTLEDYDVSFGDGVLTIKLGGDLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLARELTKALNTKLDLSSLAYSGKGT
What is the function of this protein?
Modulates the RNA-binding activity of ACO1.  May be involved in the cytoplasmic iron-sulfur protein biogenesis.  May contribute to oxidative stress resistance and overall cell survival.
What are the official names of this protein?
Frataxin, mitochondrial, Fxn.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion. Note=PubMed:17597094 describes localization exclusively in mitochondria.