PharMolix/UniProtQA huggingface dataset:
Protein: RS2_HUMAN
Sequence: MADDAGAAGGPGGPGGPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEWMPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399).  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399).  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399).  Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity).  Mutations in this protein affects the control of translational fidelity (By similarity).  Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
What are the official names of this protein?
40S ribosomal protein S2, 40S ribosomal protein S4, Protein LLRep3, Small ribosomal subunit protein uS5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: ROM1_YEAST
Sequence: MNSNELDLRNKYFYEIFGKKRKSDTSTPTQLFSGSKVQTNINEISITNDEDEDSTEDENKASLKDYTLGHDTGARYRIAPDCSSHQLKASPVLHISTNLNSSPQSFTGDQISPTNKKISINDSTRQDKGNSCTTTSSPSQKRSNVLLPHVRKHSSPSLLSFSKNSGSHMGDPNQLSTPPTPKSAGHTMELHSSFNGKHSSSSTSSLFALESLKTQNRRSSNSSNHSSQYRRHTNQHQRHHSRSKSSPVSLTEISMIKGTPLVYPALLSLIAIKFKQTIKLSTHKKMGLLYRDSFTGKQAIDTLCLIIGSLDRNLGMLIGKSLEAQKLFHDVLYDHGVRDSVLEIYELSSESIFMAHQSQSSTSIANTFSSSSSSVNSLRTKTEIYGVFVPLTHCYSSTCSLEKLCYSISCPNRLQQQANLHLKLGGGLKRNISLALDKEDDERISWTNSVPKSVWESLSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMKKLLETNIIPSDVRINFVKHVFAHINEIYSVNREFLKALAQRQSLSPICPGIADIFLQYLPFFDPFLSYIASRPYAKYLIETQRSVNPNFARFDDEVSNSSLRHGIDSFLSQGVSRPGRYSLLVREIIHFSDPVTDKDDLQMLMKVQDLLKDLMKRIDRASGAAQDRYDVKVLKQKILFKNEYVNLGLNNEKRKIKHEGLLSRKDVNKTDASFSGDIQFYLLDNMLLFLKSKAVNKWHQHTVFQRPIPLPLLFICPAEDMPPIKRYVTENPNCSAGVLLPQYQTSNPKNAIVFAYYGTKQQYQVTLYAPQPAGLQTLIEKVKQEQKRLLDETKHITFKQMVGQFFHSYINTNRVNDVLICHAGKILLVATNMGLFVLNYATSINQKPVHLLHKISISQISVLEEYKVMILLIDKKLYGCPLDVIDDAENADFLFRKNSKVLFKYVAMFKDGFCNGKRIIMIAHHFLHAVQLLIVNPLIFDFNSGNFKKNLKAGLVDFSVDSEPLSFSFLENKICIGCKKNIKILNVPEVCDKNGFKMRELLNLHDNKVLANMYKETFKVVSMFPIKNSTFACFPELCFFLNKQGKREETKGCFHWEGEPEQFACSYPYIVAINSNFIEIRHIENGELVRCVLGNKIRMLKSYAKKILYCYEDPQGFEIIELLNF
What is the function of this protein?
Stimulates the exchange of RHO1 GDP-bound form into GTP-bound form.
What are the official names of this protein?
RHO1 GDP-GTP exchange protein 1, Protein kinase C suppressor SKC1.
Protein: NEPI_ECOL6
Sequence: MSEFIAENRGANAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSYKIVATGVAIIWGLTFALIPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKKS
What is the function of this protein?
Involved in the efflux of purine ribonucleosides, such as inosine and guanosine.
What are the official names of this protein?
Purine ribonucleoside efflux pump NepI.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MACB_BURP1
Sequence: MTGPLLQLTRVTRRFPAGEKDVVVLDDVSLSIDAGEIVAIVGASGSGKSTLMNILGCLDHPSSGSYTVGGRETSELESDELARLRREHFGFIFQRYHLLPHLCAAENVEMPAVYAGSAQAQRRERALALLARLGLSDRASHRPSQLSGGQQQRVSIARALMNGGEVILADEPTGALDSKSGRDVIRVLRELNALGHTVIIVTHDEQVAAHARRIIEISDGRIVGDRLNPHADAADAAPDASGGAQPQRARRLSAGVGRFAEAFRMAWIALVSHRLRTLLTMLGIIIGITSVVSIVAIGEGAKRYMLDEIGSIGTNTINVYPGADWGDSRADAIQTLVAADAAALADQIYIDSATPETSRSLLLRYRNVDVNALVSGVGERFFQVRGMKLAQGIAFGADEVRRQAQVAVIDENTRRKLFGANPNPLGEVILIDNLPCVVIGVTASKKSAFGDMKNLNVWVPYTTASGRLFGQRHLDSITVRVRDGQPSDAAERSLTKLMLQRHGRKDFFTYNMDSVVKTVEKTGQSLTLLLSLIAVISLVVGGIGVMNIMLVSVTERTREIGIRMAVGARQTDIMQQFLVEAVTVCLMGGAIGIVLSFGMSFVFSLFVDQWKMVFSAASIASAFLCSTLIGVVFGFMPARNASRLDPIDALARD
What is the function of this protein?
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNH2_STRU0
Sequence: MTKTIKEINRLLEAISELSDPYFIELESDDRVGVKKAVNKRRKAIQAMVDEELRLDKMLSYEKVLYQEGFSLIAGIDEVGRGPLAGPVVAACVILPIDCKIKGLNDSKKIPKSKHLSIFQAIQERALGIGIGIVDNHVIDDINIYQATKVAMIEAIKNIKGDVTEPDYLLIDAMTLETPIPQQSIIKGDANSMSIAAASIVAKVTRDRLMMDYEKAFPGYDFAKNAGYGTTSHLNGLKQFGVTPIHRTSFEPIKSML
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSP3A_DANRE
Sequence: MEQMFVHIWVSLVVLMSVWSAQSDKKQDVPVIDVLGLEDVKQTVAAVEKLSLALKTLSDVYVMSTFRLPPKLGGVLLGLYNKQDNKKYLEVAIMSKINKVLVRYVREDGKLHTVNMQSPNVADGRPQSLILRVGGLRREYLSLELYVNCRLADSAQRLPPLVDLPRDAELVEIRNGHKAYARMQGSMDTLKLALGGTVAQAGALTDCPFQGDASSYNIVNGEVNSILGDHTKALIGQLIIFNQILGELREDIREQVKEMSLVRNAILECQMCGFHEPRSRCQPNPCFKGVSCMETFEYPGYRCGPCPDGMTGNGTHCQDIDECSEAQPCYTPGACVNTARGFTCESCPPGMWGPPLSGVGVEYAKSHRQECSDIDECVDLANACTPNSVCINIIGSFRCGQCKTGYVGNQTAGCFPRKSCSSLSFNPCDANAHCVMQRNGDVSCACNVGWAGNGHTCGKDTDIDGYPDRSLPCMDNHKHCRQDNCVYTPNSGQEDADNDGIGDQCDEDADGDGIKNVEDNCRLVSNKDQQNSDTDSFGDACDNCPTVPNIDQKDTDSNGEGDACDDDIDGDGIQNVLDNCPKVPNPMQTDRDRDGVGDACDSCPEISNPMQTDVDNDLVGDVCDTNQDTDGDGHQDTRDNCPDIPNSSQLDSDNDGIGDDCDEDDDNDGIPDNHAINGIGPDNCRLISNPNQKDSDSNGVGDVCENDFDNDSVMDLVDVCPESAEVTLTDFRAYQTVILDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDCAGSIFGYQDSSSFYVVMWKQTEQTYWQSIPFRAMAEPGLQLKAVKSRTGPGEFLRNALWHAGDTDGEVKLLWKDPRNVGWLDKTSYRWQLSHRPQVGYIRVKLYEGSEMVADSDVVIDTSMRGGRLGVFCFSQENIIWSNLRYRCNDTVPEDFSSHRKQVLMHIKV
What is the function of this protein?
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.  Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity).
What are the official names of this protein?
Thrombospondin-3a, Thbs3a.
What is the protein family that this protein belongs to?
Belongs to the thrombospondin family.
Protein: LEPA_SALEP
Sequence: MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDFKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVTDVLERLVRDIPPPQGDPDGPLQALIIDSWFDNYLGVVSLVRIKNGTMRKGDKIKVMSTGQTYNADRLGIFTPKQVDRTELKCGEVGWLVCAIKDILGAPVGDTLTSARNPAEKALPGFKKVKPQVYAGLFPVSSDDYESFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTAKETIYVDSPSKLPPLNNIYELREPIAECHMLLPQAYLGNVITLCIEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINNERVDALALITHRDNSQSRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MTNA_DROPE
Sequence: MSLQSIKYTRGSLEILDQLLLPVQSKYLPVRGVEDGWKVINKMQVRGAPAIAIVGCLSLAVEIHPEEFDSKKSLRQELEGKLNYLVSARPTAVNMKMAADELLSLANDLTKDDNVDVAAMKQRFLNATEAMLKKDIADNRAIGAHGAKAILQLVAAAAGAPMAGPVRVLTHCNTGSLATAGYGTALGVVRQLSELGKLEHIYCTETRPYNQGARLTAYELVHEKFPATLVLDSMVAALLRAKNVAAVVVGADRVAANGDTANKIGTYQIAVVAKHHGVPFFVAAPLTSIDLHIPSGDHIIIEERPDREMTHVGEHRIAAPGINCWNPAFDVTPASLITGIITERGVFQPAQLKETITKLLET
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CR6AA_BACTU
Sequence: MIIDSKTTLPRHSLIHTIKLNSNKKYGPGDMTNGNQFIISKQEWATIGAYIQTGLGLPVNEQQLRTHVNLSQDISIPSDFSQLYDVYCSDKTSAEWWNKNLYPLIIKSANDIASYGFKVAGDPSIKKDGYFKKLQDELDNIVDNNSDDDAIAKAIKDFKARCGILIKEAKQYEEAAKNIVTSLDQFLHGDQKKLEGVINIQKRLKEVQTALNQAHGESSPAHKELLEKVKNLKTTLERTIKAEQDLEKKVEYSFLLGPLLGFVVYEILENTAVQHIKNQIDEIKKQLDSAQHDLDRDVKIIGMLNSINTDIDNLYSQGQEAIKVFQKLQGIWATIGAQIENLRTTSLQEVQDSDDADEIQIELEDASDAWLVVAQEARDFTLNAYSTNSRQNLPINVISDSCNCSTTNMTSNQYSNPTTNMTSNQYMISHEYTSLPNNFMLSRNSNLEYKCPENNFMIYWYNNSDWYNNSDWYNN
What is the function of this protein?
Pore-forming toxin with nematicidal activity (PubMed:26795495, PubMed:27576487).  In infected C. elegans, induces an increase in intracellular Ca(2+) resulting in necrosis of host intestinal cells (PubMed:26795495).  Also, induces the expression of aspartic protease asp-1 (PubMed:26795495).
What are the official names of this protein?
Pesticidal crystal protein Cry6Aa, Crystaline entomocidal protoxin, Crystal protein, Insecticidal delta-endotoxin CryVIA(a).
What is the protein family that this protein belongs to?
Belongs to the cry6A endotoxin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane. Note=Probably secreted as a soluble protein that then inserts into the host membrane and forms pores.
Protein: NUOB_ORITB
Sequence: MSENTFSDTTSIYNQNLSNQGFILANLENLVSWARTRSLWPMTFGLACCAIEMMQTAGSRYDMDRYGMLFRPSPRQADVMIVAGTLTNKMAPALRRVYDQMTEPKWVISMGSCANGGGYYHYSYSVVRGCDKIVPVDIYVPGCPPTPEALLYGILQLQKKINRTQQVKFKR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL20_CUPNH
Sequence: MPRVKRGVTARARHKKVIDAAKGYRGRRNNVYRIAKQAVMRAGQYAYRDRRNKKRVFRALWIARINAATREHGMTYSVFMNGLKKASIELDRKVLSDMAIHDKPAFAAIVNQVKATVA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CIMA_STRCO
Sequence: MTATSELDDSFHVFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARARQEIDFKHAQLVAFGSTRRAGANAAEDHQVKALLDSGAQVITLVAKSHDRHVELALRTTLDENLAMVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGADVVVLCDTNGGMLPAQIQAVVATVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNANLFPVVAALELKYGKQVLPEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAGLHASAIKVDPDLYQHIDPELVGNTMRMLVSDMAGRASIELKGKELGIDLGGDRELVGRVVERVKERELAGYTYEAADASFELLLRAEAEGRPLKYFEVESWRAITEDRPDGSHANEATVKLWAKGERIVATAEGNGPVNALDRSLRVALEKIYPELAKLDLVDYKVRILEGVHGTQSTTRVLISTSDGTGEWATVGVAENVIAASWQALEDAYTYGLLRAGVAPAE
What is the function of this protein?
Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
What are the official names of this protein?
(R)-citramalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Protein: RL14_MYCTU
Sequence: MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKDAIPGGNVKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGTRIFGPVGRELREKRFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: OXLA_BUNMU
Sequence: MNVFSIFSLVFLAAFGSCADDRRSPLEECFREADYEEFLEIARNGLKKTSNPKHVVVVGAGMAGLSAAYVLEKAGHRVTLLEASDRVGGRANTYRDEKEGWYVNMGPMRLPERHRIVRTYIAKFGLKLNEFFQENENAWYFIRNIRKRVWEVKKDPGVFKYPVKPSEEGKSASQLYRESLKKIIEELKRTNCSYILDKYDSYSTKEYLIKEGNLSRGAVDMIGDLLNEDSSYYLSFIESLKNDDLFSYEKRFDEISGGFDQLPKSMHQDIAEMVHLNAQVTKIQHDAEKVRVAYQTPAKTLSYVTADYVIVCATSRAVRRISFEPPLPSKKAHALRSIHYKSATKIFLTCTQKFWEADGIHGGKSTTDLPSRFIYYPNHNFTSGVGVIVAYVLADDSDFFQALDIKTSADIVINDLSLIHQLPKNEIQALCYPSLIKKWSLDKYTMGALTSFTPYQFQDYSETVAAPVGRIYFAGEYTARVHGWLDSTIKSGLTAARDVNRASQKPSRIHLISDNQL
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme.  Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation.  Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation.  These different effects are probably due to different experimental conditions (By similarity).
What are the official names of this protein?
L-amino-acid oxidase, Bm-LAAO, LAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CHO2_CANTT
Sequence: MPSLTQTRSTVSELNTSAIETSTMSDSGHQNKPKGPKGITFSGETFIVPETHDMVKTLFDPTIKKSNFELIILGLLFSNLLVFLIPNNNLRISIFIGFYIFWRLSYNFGIGWLLQHQSNDHLLVQWAIKYKLFDKNNKNFLAKLVQSEIKSQRGDAYDINSYPIEFNTWLIFRKFVDLILMSDFTTFICVVYACSINNDYQFIKNQPSWLTMSRIVGGSILILFNYWVKVNAHNTIKDYAWYWGDFFFRQINNEELIFDGVFEMFPHPMYSVGYVGYYGFALISKSYIVLLTAIFGHFLQMIFLHYIENPHIDKIYGPSKNEINLIKILKLKDLKNFDNLKPLVGLYNFNWMRASDVINLVLSLTYGLIIPVFAKSLKSLFVLTVATKLFESLSINILLILQSQFKFFTKWSLSNDIPIEKSLNNWAVLYNSLINLTYSSLFGLNLGYFLQGTGSSLVTDYFYLRLFLGLCLIYTQSWINLSIIDSIGYFGWFYGDFFIPKSQSSIKNLTQAGVYRYLNNPEQIFGVCGVMGVFLIHPTVENLTCCILWMVNNFVRINFIEKIHMIRIYGEKEVNRDSGVTKTVKKHLIPDVIQRKMSNDDPKRRGGVANGTSLGDSLDNFIKELRNSTTKLSQQKLIELSQNLSFANSNYKLSIDGLKESNELKYTTIGTPITVSWQSPSNTHSIRDWVGLYKIVQTSYSRNKTILSSAGRWTYCTDSKGVFTFEKEKLFWEEGVYEFRYHLDGKHDVAYISEPFEIKSVDIDVPGDISEAGEFSKQLKTEIFDKIIDIKSINESIAPIANQADNVIEVYKLFSSLISKSTQINVNYRIFLNNDNLSISDVAHKLIDIKQVLQELSFNSSEKKNL
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RECU_LATSS
Sequence: MAFHYPNGQPYSNHETKQPKKQGRHTSPTTLYGKRGMSLEEEINDSNQYYRLRDAAVIYKKPTPIQIVKVDYPARSQAVIKEAYFKQASTTDYNGIYQGHYVDFEAKETKNKTSFPFQNFHQHQIDHFRACLQQGGVCFVIMKFVPLQRLFVYPASLLITQWDNQATGGRKSIPLAAIVADGFEIQYQLNPSIPYLEAVDQLIARHHKGV
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_ACIB3
Sequence: MTVQIITIDGPSGSGKGTLAAKLAAYYQFHLLDSGALYRLLGLSLHKHDLLEKLDSHLDMCVNYARQLNIKFETSAEGTLVFLDGEDVTQTIRTERVGEYASKVAAIPELRQALFERQRAFAQTPGLVADGRDMATSIFPEANAKIYLTASAESRAERRVKQLQGMGLDAKINDILANIQARDKRDMEREVAPLKPAADAYIIDSSELTIDQVFKLMVDYVNSRTVSN
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_IDILO
Sequence: MARVKRGVIARARHKKVLKQAKGYYGARSRVYRVAVQAVTKAGQYAYRDRRNKKRQFRQLWIVRINAAARQNGLSYSRFINGLKKASIEIDRKILADIAVHDQNGFAALVEKAKGAL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NDB2T_OPICA
Sequence: GKVWDWIKKTAKDVLNSDVAKQLKNKALNAAKNFVAEKIGATPSEAGQMPFDEFMDILHYY
What is the function of this protein?
At high concentrations, acts as pore former in cellular membranes and causes the leakage of the cells.  At submicromolar concentrations, degranulates granulocytes and has a weak hemolytic activity against human erythrocytes.  Also strongly inhibits the production of superoxide anions.  Has a strong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria.  Also has antifungal activity.
What are the official names of this protein?
Opistoporin-4.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Long chain multifunctional peptide (group 2) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: LPXK_JANMA
Sequence: MALQRSNLEEFLTQTWAQRGLAACMLLPVSAVFGGLSALRRAAYRLGLSKSERLPVPVVVVGNIFVGGTGKTPLTIWLVHVLRQAGYTPGVISRGYGVHNDVPQAVTPQSLAQEVGDEPLLIAYRAECPVMVGRDRVAVATALLAAHPEVDVLLSDDGLQHYRMARDVEIVLFDGRGAGNGWLLPAGPLREPVSRRRDFTVLNGAADAPGLPPDAIRMQLVGMTAEKLNDRSQTSALSSFAASDGKHAPTILAAAGIGNPGRFFGLLRSAGLQFEEMALPDHYDFADNPFAHVKADVILITEKDAVKCRQNEGLRNDTRLWVVPVTAQLDGALAEKIVEKLRGRSIA
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: ATPE_BURMA
Sequence: MATIKVDVVSAEEQIFSGQAKFVALPGEAGELGILPGHTPLITRIRPGAVRIESESGDEEFVFVAGGILEVQPGAVTVLADTAIRGKDLDAAKAEEARKRAEETLQNAKSDIDLAKAQSELATAMAQLEAIQRLAKIRGKH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RLMH_PROMS
Sequence: MLQSNRLTIYAIGKIKKHWIRDGINQYKKRMPELIINESKTFNLDNLRSNNNIIICLSEEGKQFNSVELCSLLLNFKNKKINFLIGDTDGVSSDIKEKSDLVLSLSPLTFPHELARLILIEQIYRAISISNNSPYHRS
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIRI_LEPMC
Sequence: MLSQRSQRNTSEIIPRLLREYHQPQAGNIDILDLSQAENSVLRDETLDEIRSAIGKHLNGSNLSYPTGVGGELAARKSLAMFFNDRFNPARSVSPDHIVMTPGASEALETLIFHICDPGEGVLIAAPYWSGLDLALETRSLARIVQVNIPLHEFFEMSSIQYYERALATSPIPIKAILMCNPHNPLGQCYNADVLEGLLGFCQRNKLHYISDEVYGMSVFSDSDKGVTPAFTSILSHATAPGLTSWVHMVYSLSKDFGCSGLRLGAIVTQGNTDLLLGSALITNNKVSSLTSVIVPSLLEPRTTQKLLNQNLRSRLNLNYGKVQRFLENRGLEFVPAKAGLFVFACLGKTRTEKEQLLLIECMKRSGVKLVAGTSFHFEQFCWFRIMFSLPKNIVDVALQRIGDALDETEKLL
What is the function of this protein?
Probable aminotransferase; part of the gene cluster that mediates the biosynthesis of sirodesmin PL, an epipolythiodioxopiperazine (ETP) characterized by a disulfide bridged cyclic dipeptide and that acts as a phytotoxin which is involved in the blackleg didease of canola (PubMed:15387811, PubMed:18272357, PubMed:19762440).  SirD catalyzes the O-prenylation of L-tyrosine (L-Tyr) in the presence of dimethylallyl diphosphate (DMAPP) to yield 4-O-dimethylallyl-L-Tyr, and therefore represents probably the first pathway-specific enzyme in the biosynthesis of sirodesmin PL (PubMed:19762440, PubMed:21038099, PubMed:24083562).  4-O-dimethylallyl-L-Tyr, then undergoes condensation with L-Ser in a reaction catalyzed by the non-ribosomal peptide synthase sirP to form the diketopiperazine (DKP) backbone (PubMed:18272357).  Further bishydroxylation of the DKP performed by the cytochrome P450 monooxygenase sirC leads to the production of the intermediate phomamide (PubMed:27390873).  This step is essential to form the reactive thiol group required for toxicity of sirodesmin PL (PubMed:27390873).  The next steps of sirodesmin biosynthesis are not well understood yet, but some predictions could be made from intermediate compounds identification (PubMed:18272357).  Phomamide is converted into phomalizarine via oxidation, probably by sirT (PubMed:18272357).  Further oxidation, methylation (by sirM or sirN) and reduction steps convert phomalizarine to deacetyl sirodesmin (PubMed:18272357).  Finally, acetyltransferase sirH probably acetylates deacetyl sirodesmin to produce sirodesmin PL (PubMed:18272357).
What are the official names of this protein?
Probable aminotransferase sirI, Sirodesmin biosynthesis protein I.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.