PharMolix/UniProtQA huggingface dataset:
Protein: EBP_RAT
Sequence: MTTNMLPLHPYWPRHLRLDNFVPNDLPTWHILVGLFSFSGVLIVITWLLSSRVSVVPLGTGRRLALCWFAVCTFIHLVIEGWFSFYHEILLEDQAFLSQLWKEYSKGDSRYILSDGFIVCMESVTACLWGPLSLWVVIAFLRHQPFRFVLQLVVSVGQIYGDVLYFLTELRDGFQHGELGHPLYFWFYFVIMNAIWLVIPGILVFDAIKHLTNAQSMLDNKVMKIKSKHN
What is the function of this protein?
Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
What are the official names of this protein?
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, Cholestenol Delta-isomerase, Delta(8)-Delta(7) sterol isomerase, D8-D7 sterol isomerase, Emopamil-binding protein, Sterol 8-isomerase.
What is the protein family that this protein belongs to?
Belongs to the EBP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Cytoplasmic vesicle. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles.
Protein: SRY_ARCFO
Sequence: MFGVLNSDDHRAAIQQRNILAFGRTSSELWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAVHREKYPDYKYRPRRKALPQKSDKLLPAASSSLLCRQVLVDKWYPFTYRDSCSRATHSHMEDQLSSSQPVNIANSLLQQEHHYSSTSLRGSPETLATHLSADPPFYPK
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: VM2MC_GLOBR
Sequence: MIQVLLVIICLADFPYQGTSIILESGNVNDYEVVYPRKVTALPKGAVQPKYEDAMQYEFKVNGEPVVLHLEKNKGLFSKGYSETHYSPDGRKITTNPPVEDHCYYHGRIQNDADSTASISACNGLKGHFKHQGEMYLIEPLKLSDSEAHAVYKYENVEKEDEAPKMCGVTQTNWKSDEPIKASQQQRFPQRYIELVVVADHGMFTKYDSNLDTIRTWVHELVNSINEFYRSLNIDVSLTELEIWSNQDLINVQSAAGDTLEAFGDWRETDLLNRISHDNAQLLTATELDGNTIGLAHVASMCDPKRSTGVVQDHSAINLLVAVTMAHETGHNLGMNHDGNQCHCGANSCVMGDVLSEGVSYEFSDCSENEYQTYLTDRNPQCILNEPLRTDTVSTPVSGNELLEAGKECDCGAPANPCCDAETCKLRPGQQCAEGLCCDQCRFMKEGTICQEAKGDWNDDTCNGISAGCPRNGFYG
What is the function of this protein?
Inhibits ADP-induced platelet aggregation.
What are the official names of this protein?
Zinc metalloproteinase/disintegrin.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IId sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: P59_LIYV9
Sequence: MLNDRIAVTCFQTLLKKSNVKHEMEQTNNYIVNNLADINRNTFPALAGSVRIDFNSDYYISGGQIVVSPKDSNAYVKLLIVYLKYCYINYSAKTKYPPQSLLAVLDYDSFKAKWVKYLDKSLTDYLDDNKTEGCSFTEQQVVEKYPQVDSLVAKILYRVCNSLGKLLDLKDFENKNISGFEINTAQDSPTVADDNESNDFFRECVNDQRYYSSLSGSKLGKAKLEANAYIFKILLKSASGEFDIDRLSRNPLAISKFMNLYTNHVTDSETFKSKFEALKSIKTPFASFIKKAFGIRLNFEDSKIFYALPKERQSDVLSDDMMVESIVRDAASFTVVSDNNYLPERVDRFVTQLLLELFPKTKASFPNKIMFGFLHYFALSTTNSKRFNDTQESTIEIEGETLKISLKFITSYLRNAIQSQHPDYADSNIVRLWCNKRSNLALGYFKSRNIQLYLYSKYPRLLNYMRFDYFKGLDMGKLTDEERLSIQTLRCITEDRSEGTLATHNDLNSWILRP
What are the official names of this protein?
Protein p59.
What are the subcellular locations of this protein?
Virion.
Protein: TM192_HUMAN
Sequence: MAAGGRMEDGSLDITQSIEDDPLLDAQLLPHHSLQAHFRPRFHPLPTVIIVNLLWFIHLVFVVLAFLTGVLCSYPNPNEDKCPGNYTNPLKVQTVIILGKVILWILHLLLECYIQYHHSKIRNRGYNLIYRSTRHLKRLALMIQSSGNTVLLLILCMQHSFPEPGRLYLDLILAILALELICSLICLLIYTVKIRRFNKAKPEPDILEEEKIYAYPSNITSETGFRTISSLEEIVEKQGDTIEYLKRHNALLSKRLLALTSSDLGCQPSRT
What are the official names of this protein?
Transmembrane protein 192.
What is the protein family that this protein belongs to?
Belongs to the TMEM192 family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Late endosome.
Protein: RL23_COLP3
Sequence: MINEERLLKVLLAPNISEKATTAAEANNTVVFKVATDATKAEIKAAVEKLFEVTVEGVNTLNVKGKVKRTGARFGRRNDWKKAYVTLAEGSDIDFVGAES
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: DNCH_SYNSC
Sequence: MTSAPWLELSRTVRFSDTDAAGVMHFQQLLGWCHQAWEESLERYGLTAGSVFPGGRREQPSVALPIVHCHADYRAPVQVGDKLLIRLKPERLDPSSFVVNSQVLLNEQLVASGCLRHVAIDANSRRRCALPDGVDRWLEASSLGRIQPL
What is the function of this protein?
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA hydrolase, DHNA-CoA hydrolase, DHNA-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: PMIP_YEAST
Sequence: MLRTIILKAGSNASIPSPSRQNKLLRFFATAGAVSRTSPGSIKKIFDDNSYWRNINGQDANNSKISQYLFKKNKTGLFKNPYLTSPDGLRKFSQVSLQQAQELLDKMRNDFSESGKLTYIMNLDRLSDTLCRVIDLCEFIRSTHPDDAFVRAAQDCHEQMFEFMNVLNTDVSLCNILKSVLNNPEVSSKLSAEELKVGKILLDDFEKSGIYMNPDVREKFIQLSQEISLVGQEFINHTDYPGSNSVKIPCKDLDNSKVSTFLLKQLNKDVKGQNYKVPTFGYAAYALLKSCENEMVRKKLWTALHSCSDKQVKRLSHLIKLRAILANLMHKTSYAEYQLEGKMAKNPKDVQDFILTLMNNTIEKTANELKFIAELKAKDLKKPLTTNTDEILKLVRPWDRDYYTGKYFQLNPSNSPNAKEISYYFTLGNVIQGLSDLFQQIYGIRLEPAITDEGETWSPDVRRLNVISEEEGIIGIIYCDLFERNGKTSNPAHFTVCCSRQIYPSETDFSTIQVGENPDGTYFQLPVISLVCNFSPILIASKKSLCFLQLSEVETLFHEMGHAMHSMLGRTHMQNISGTRCATDFVELPSILMEHFAKDIRILTKIGKHYGTGETIQADMLQRFMKSTNFLQNCETYSQAKMAMLDQSFHDEKIISDIDNFDVVENYQALERRLKVLVDDQSNWCGRFGHLFGYGATYYSYLFDRTIASKIWYALFEDDPYSRKNGDKFKKHLLKWGGLKDPWKCIADVLECPMLEKGGSDAMEFIAQSHKS
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.  Cleaves precursor proteins of respiratory components, including subunits of the electron transport chain and tricarboxylic acid cycle enzymes, and components of the mitochondrial genetic machinery, including ribosomal proteins, translation factors, and proteins required for mitochondrial DNA metabolism.
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ACTP_ECOBW
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMMGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSITVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PNP_LEPBA
Sequence: MATEFTGVWGRDSITLETGKWAKQAHGSVVYKTGNLVLLATVCAAEEPKEGQDFFPLTCEYTEKAYSVGRFPGGYFKREAKPAEHEVLLSRILDRPIRPMFPEGYFSEVQLLVQVLSADKQVSVQGHAINAASAALSVSSIPFAGPIAGARIGRIGGEFILNPTNEEITKSDLDLVVAGTKDAIVMIEGEASEISKEDMMAALRFAQEQLKFAVAMQEELAKKHGTVKKEVVLKAPDKDLHAKIREFAFDRLTLANKNADKAKRNDDIKAINKETVEHFKTLLAPEDKTKDIKHFLHELEYEVVRELVLGEGIRFDGRKTDEIRQISCEIDVLPGPHGSAVFTRGQTQSLGVMTLGTTSDNQRYETLEGSKEKNFMLHYNFPAFSVGEVRRNSGPGRREIGHGNLAERAIKKVLPTQTEFPYVIRLVSEILESNGSSSMASVCSGTLALMAGGVPISGAVSGIAMGLFSDEKGRFAVLSDIAGIEDHFGDMDFKLAGTKKGITAFQMDLKVNGLGLEVLQKAIEQAEVGRDHILGEMNKAISSVKGNLSENAPRITQKQIPKDRIGELIGPGGKMIRAIIEQSGSEISVDDSGKVTIASPSEESKEKAIAMIDGIFEEIEVGKIYDGVIKRIADFGAFVEILPGKEGLCHISKLDVKRVQSVRDIVSEGDKIKVKVISVDKMGKIDLSRKDVLLDN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAE1_ASPTN
Sequence: MLAIGLEGSANKLGVGIMLHPDDGSSPQVLANVRHTYVSPPGEGFLPKDTARHHRAWVVRLVKRTLREARISPDDVDCICFTQGPGMGAPLQSVAVAARMLSLLWKKPLVGVNHCVGHIEMGRLITGSTNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKKGKQLVELPYTVKGMDCSFSGMLAAIDALAASYGLDGPQSDEAVDANSPAAVEAGENGKPTRADLCFSLQETIFSMLVEITERAMAHVGSKEVLIVGGVGCNERLQEMMGIMARDRGGSVHATDERFCIDNGIMIAQAGLLAYKTGFRTPLKESACTQRFRTDAVFVKWRD
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein kae1, tRNA threonylcarbamoyladenosine biosynthesis protein kae1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FTSH_SYNFM
Sequence: MARKSDEDTNPMDKFMDRLRGSPGDGGPGRPDPSQRKVHFSIWYFILALLLIVWMQTYMGEQQSEKISYSEFKQRVHDGNVQNLVIEHDRITGTMKENDGPGRRFNTIRVEDPELVKQLEAKNIRFSGDVQNPWLGLITWWLLPFAIMIFFWSFLMRRMGGGPQGVLSVGKARVKIFAEKEITITFDDVAGIDEAKGELEEIVQFLKDPGKFQRLGGRIPKGVLLVGAPGTGKTLLAKAVAGEAGVPFFSMSGSEFVEMFVGVGAARVRDLFGQAKDHAPCIIFIDELDALGKARGLNPIGGHDEREQTLNQLLVEMDGFDPRSGVIIMAATNRPEILDPALLRPGRFDRHVAIDKPDIRGREAILRVHVKEVKLGSEVDLKKIAGMTPGFVGADLANLVNEAALVAARRDRDEVTMADFQEAADRIIGGLEKKNRAMNPKEKEIVAYHEAGHALVAMLLPNVDPVNKVSIIPRGIAALGYTQQLPTEDRYLMTRNELLDRLQVLLGGRVSEEIIFGDVSTGAQNDLQRATDIARSMVMEYGMSERLGPLTYTRDPRSAHLDLGLGSRERDYSEMIAQEIDEEITRIVEDAHEKVRATLKRERGCLEKLAKILLEKESIDGEELKQFCQEVKSHIARDPVQVEGGAA
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: RF1_LIGS1
Sequence: MDKLFDRLQMLEDRYEELGELLSDPDVISDTKRFTKLSKEMADLRETVEKYNKYKEVTQQISDDEEMLSDGLDDEMASLVKEELSNAKNEKVKLEEEIKILLLPKDPNDDKNIIMEIRGAAGGDEASLFAADLFSMYSKYAERQGWSIEVIDKNVTEVGGFKEIALIINGNSVWSKLKYESGAHRVQRIPVTESAGRVHTSTATVVVMPEEEDVEIELDPKDIRVDVYRSSGAGGQHINKTSSAVRMTHLPTGIVVAMQDQRSQQQNREKAMKILKARVYDYYAQQEQSEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRIGLSLNKLDRIMNGELEDVIDALVLFEQTKAMEKLENE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBIH_SCHPO
Sequence: MSSSSSHNSFSGSKTNAAEGQNSIDGLSLKKTTSPFILTAYPSNEEKEVKETDIVPDENKVNELDVHKQSTEFSKQESASNDDDTNIQLIPENNMKIVVPALILTLFLAALDNTIVTTALPTIAEDFNDTSSSSWIGSAYVLASNAVLPAVGVFCNILGRKIVLYICIFFFMLGSALCGASQNMIWLIVCRAIQGLGGGGIISLVNIIISDITPLRTRPMYSGILATAWGAALVAGPIIGGAICQRTTWRWIFFINLPSGGIATALIVVFLHLLPCERTSFKKFLKTFDFIGLVCVITGIVLILLGISLGASSGKWRRANILCYLIIGGCLFVFAFIYDTFTKRNAVLPPPFFKNRSSAALLACSSFFYLNYMLFAYYVPQYFQRIRGDNPIMSGVHTIPCAAVLCFFCTTVGMVLRKLGRYLPLIYVGYISCVAGMGAMICVNATTSMSKVMGLTTIFMFGSGFLFLPPLIAMQATFPPAMTSMATATLMFIRTMGGSIGITVGEVIFNERVTQSFDGNTTYAQLSYKQVERLPQELQIRVKNTYASAFRVIWIFCTVVMAIGFASIFFIKSRPLISNAQSVPAKKKGDSDEKPAEKV
What are the official names of this protein?
Uncharacterized MFS-type transporter C16A3.17c.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ADF8_ARATH
Sequence: MANSASGMHVNDECKIKFLELKAKRTYRFIVFKIDEKAQQVQIEKLGNPEETYDDFTSSIPDDECRYAVYDFDFTTEDNCQKSKIFFIAWSPDTSRVRSKMLYASSKDRFKREMEGIQVELQATDPSEMSLDIIKGRLNL
What is the function of this protein?
Actin-depolymerizing protein.  Severs actin filaments (F-actin) and binds to actin monomers.
What are the official names of this protein?
Actin-depolymerizing factor 8, ADF-8, AtADF8.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TRAI1_ECOLI
Sequence: MMSIAQVRSAGSAGNYYTDKDNYYVLGSMGERWAGRGAEQLGLQGSVDKDVFTRLLEGRLPDGADLSRMQDGSNRHRPGYDLTFSAPKSVSMMAMLGGDKRLIDAHNQAVDFAVRQVEALASTRVMTDGQSETVLTGNLVMALFNHDTSRDQEPQLHTHAVVANVTQHNGEWKTLSSDKVGKTGFIENVYANQIAFGRLYREKLKEQVEALGYETEVVGKHGMWEMPGVPVEAFSGRSQTIREAVGEDASLKSRDVAALDTRKSKQHVDPEIKMAEWMQTLKETGFDIRAYRDAADQRADLRTLTPGPASQDGPDVQQAVTQAIAGLSERKVQFTYTDVLARTVGILPPENGVIERARAGIDEAISREQLIPLDREKGLFTSGIHVLDELSVRALSRDIMKQNRVTVHPEKSVPRTAGYSDAVSVLAQDRPSLAIVSGQGGAAGQRERVAELVMMAREQGREVQIIAADRRSQMNMKQDERLSGELITGRRQLLEGMAFTPGSTVIVDQGEKLSLKETLTLLDGAARHNVQVLITDSGQRTGTGSALMAMKDAGVNTYRWQGGEQRPATIISEPDRNVRYARLAGDFAASVKAGEESVAQVSGVREQAILTQAIRSELKTQGVLGLPEVTMTALSPVWLDSRSRYLRDMYRPGMVMEQWNPETRSHDRYVIDRVTAQSHSLTLRDAQGETQVVRISSLDSSWSLFRPEKMPVADGERLRVTGKIPGLRVSGGDRLQVASVSEDAMTVVVPGRAEPATLPVSDSPFTALKLENGWVETPGHSVSDSATVFASVTQMAMDNATLNGLARSGRDVRLYSSLDETRTAEKLARHPSFTVVSEQIKTRAGETSLETAISHQKSALHTPAQQAIHLALPVVESKKLAFSMVDLLTEAKSFAAEGTGFTELGGEINAQIKRGDLLYVDVAKGYGTGLLVSRASYEAEKSILRHILEGKEAVMPLMERVPGELMEKLTSGQRAATRMILETSDRFTVVQGYAGVGKTTQFRAVMSAVNMLPESERPRVVGLGPTHRAVGEMRSAGVDAQTLASFLHDTQLQQRSGETPDFSNTLFLLDESSMVGNTDMARAYALIAAGGGRAVASGDTDQLQAIAPGQPFRLQQTRSAADVAIMKEIVRQTPELREAVYSLINRDVERALSGLESVKPSQVPRQEGAWAPEHSVTEFSHSQEAKLAEAQQKAMLKGEAFPDVPMTLYEAIVRDYTGRTPEAREQTLIVTHLNEDRRVLNSMIHDVREKAGELGKEQVMVPVLNTANIRDGELRRLSTWETHRDALVLVDNVYHRIAGISKDDGLITLQDAEGNTRLISPREAVAEGVTLYTPDTIRVGTGDRMRFTKSDRERGYVANSVWTVTAVSGDSVTLSDGQQTREIRPGQEQAEQHIDLAYAITAHGAQGASETFAIALEGTEGNRKLMAGFESAYVALSRMKQHVQVYTDNRQGWTDAINNAVQKGTAHDVFEPKPDREVMNAERLFSTARELRDVAAGRAVLRQAGLAGGDSPARFIAPGRKYPQPYVALPAFDRNGKSAGIWLNPLTTDDGNGLRGFSGEGRVKGSGDAQFVALQGSRNGESLLADNMQDGVRIARDNPDSGVVVRIAGEGRPWNPGAITGGRVWGDIPDNSVQPGAGNGEPVTAEVLAQRQAEEAIRRETERRADEIVRKMAENKPDLPDGKTEQAVREIAGQERDRAAITEREAALPEGVLREPQRVREAVREIARENLLQERLQQMERDMVRDLQKEKTLGGD
What is the function of this protein?
TraI has also been identified as DNA helicase I.  DNA.  helicase I is a potent, highly processive DNA-dependent ATPase, able to unwind about 1. 1 kb dsDNA per second in a 5' to 3' manner.
What are the official names of this protein?
Multifunctional conjugation protein TraI.
What is the protein family that this protein belongs to?
To TraI of plasmid IncFII R100.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_STAA8
Sequence: MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNVLLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVDSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVTAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIEKTKAHVAMIEAVRITLKNALAMVGVSAPESM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPM8_HUMAN
Sequence: MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDRNGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKIK
What is the function of this protein?
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius.  Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH.  Involved in menthol sensation.  Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.  Temperature sensing is tightly linked to voltage-dependent gating.  Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves.  The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials.  Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.  In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity.  Plays a role in prostate cancer cell migration (PubMed:25559186).  Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
What are the official names of this protein?
Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells.
Protein: HPCL1_BOVIN
Sequence: MGKQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTVDEFKKIYANFFPYGDASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRSEMLEIVQAIYKMVSSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDPSIVRLLQCDPSSASQF
What is the function of this protein?
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
What are the official names of this protein?
Hippocalcin-like protein 1, Neurocalcin-gamma.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor.
Protein: CYB_LEPLC
Sequence: MTNIRKTHPLMKIINSSLIDLPTPPNISSLWNFGSLLGACLAIQIITGLFLAMHYTADTTTAFSSVTHICRDVNYGWAIRYLHANGASTFFLCLFIHVGRGLYYGSFALLETWNIGIMLLLSVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGIDLVEWIWGGFSVGKPTLTRFFALHFILPFIISALTMIHLLFLHETGSNNPLGVSSNSDKIPFHPYYTTKDSLGFLLLILLLMTLTLFYPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVMALILSILILAIIPLLQPIKQQTMMFRPLSQFLFWILVADLLTLTWIGGQPVEDPFINIGQMASILYFSLVIFIMPMICLIENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YBED_ECOK1
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.