PharMolix/UniProtQA huggingface dataset:
Protein: COX3_ALKPO
Sequence: MAGAVDTSKGLPSHPERATLEGKNKFLGFWFFLGGETILFATFFGTFLGLRGGTADGPTSADLVALDLVFIMTMLLLTSSLTSVLAMFAMKKNNFKAMMIWMWITVVLGLAFLGFEIYEFHHYVVDYQFGFSTSAFASAFYSLVGLHGAHVAFGLSWIIVLLIRYRKSGITLTNAPKFYVAGLYWHFIDVVWVFIFTVVYLMGVGG
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome aa3 subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MDTC_KLEP3
Sequence: MKFFALFIYRPVATILISLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTRIILEFNFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGELYDFASTQLAQTIAQIDGVGDVDVGGSSLPAVRVDLNPQALFNQGVSLDAVRTAISDANVRKPQGALEDSAHRWQVQTNDELKTAADYQPLIVHYQNGAAVRLGDVATVSDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRARLPELQQTIPAAIDLQIAQDRSPTIRASLEEVEQTLVISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGSREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLAVSLTLTPMMCGWLLKSGKPHQPTRNRGFGRLLVAVQGGYGKSLKWVLRHSRLTGLVVLGTIALSVWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIREDPAVDNVTGFTGGSRVNSGMMFITLKPRDQRHETAQQVIDRLRKKLANEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLSALREWEPKIRKALAALPELADVNSDQQDNGAEMDLVYDRDTMSRLGISVQDANNLLNNAFGQRQISTIYQPLNQYKVVMEVDPAYTQDVSALDKMFVINSEGKPIPLAYFAKWQPANAPLSVNHQGLSAASTISFNLPTGRSLSEASDAINRTMTQLGVPSSVRGSFAGTAQVFQQTMNAQVILILAAIATVYIVLGMLYESYVHPLTILSTLPSAGVGALLALEIFDAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRTGNLAPEEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRHSSQPVSE
What are the official names of this protein?
Multidrug resistance protein MdtC, Multidrug transporter MdtC.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMA_RICB8
Sequence: MLPSIAKHAASHQIHPLKKHGQNFIFDGSLCDKIVRASGLEENSNVLEIGPGTGGLTRSILHKNPKLLTVIETDERCIPLLNEIKQYHPNLNIIKQDALKLKLSDLNTNKITIISNLPYHIGTELVIRWLKESSLVASMTLMLQKEVVERICAKPSTKAYGRLSVICSLIATVEKCFDVAPTAFYPPPKVYSAIVKLTPLENIPNSDLISKVELITKMAFAGRRKMIKSSLKNLAPNISELLAKLNISNNCRAENLTPNDYLSLASLI
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PIPHE
Sequence: MTNIRKSHPLIKIINDSFIDLPAPSNISAWWNFGSLLGICLALQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGLYYGSYLFKETWNMGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFLLPFIISALVMVHLLFLHETGSNNPTGIPSNVDMIPFHPYYTIKDILGLFMMILILLSLVLFSPDMLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILIIIPFLHTSKQRSMTFRPISQCLFWLLAADLLTLTWIGGQPVEHPYVIIGQLASILYFLIIIAIMPLAGLMENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: T2R10_HUMAN
Sequence: MLRVVEGIFIFVVVSESVFGVLGNGFIGLVNCIDCAKNKLSTIGFILTGLAISRIFLIWIIITDGFIQIFSPNIYASGNLIEYISYFWVIGNQSSMWFATSLSIFYFLKIANFSNYIFLWLKSRTNMVLPFMIVFLLISSLLNFAYIAKILNDYKTKNDTVWDLNMYKSEYFIKQILLNLGVIFFFTLSLITCIFLIISLWRHNRQMQSNVTGLRDSNTEAHVKAMKVLISFIILFILYFIGMAIEISCFTVRENKLLLMFGMTTTAIYPWGHSFILILGNSKLKQASLRVLQQLKCCEKRKNLRVT
What is the function of this protein?
Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
What are the official names of this protein?
Taste receptor type 2 member 10, T2R10, Taste receptor family B member 2, TRB2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y208_LISGR
Sequence: MITTTSPTIEGKQIIEYKKIVFGEVITGINVLKDIGAGIRNFFGGRSGGYEEELIQAREAAIEEMENRAEALGANAIIAVDVDYEVLGADNGMLMVSVSGTAVVVE
What are the official names of this protein?
UPF0145 protein.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: RBS_PORCA
Sequence: MRLTQGTFSFLPDLTDEQISKQLTYIVSKGLSANVEYTDDPHPRNSYWELWGLPLFDVKDASAVMYEISSCRKAKPNYYIKVNAFDNTRGIESCVMSFIVNRPINEPGFLLQRQDFEGRTMKYSLHSYATEKPEGARY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IDI2_STRP8
Sequence: MTNRKDDHIKYALKYQSPYNAFDDIELIHHSLPSYDLSDIDLSTHFAGQDFDFPFYINAMTGGSQKGKAVNEKLAKVAAATGIVMVTGSYSAALKNPNDDSYRLHEVADNLKLATNIGLDKPVALGQQTVQEMQPLFLQVHVNVMQELLMPEGERVFHTWKKHLAEYASQIPVPVILKEVGFGMDVNSIKLAHDLGIQTFDISGRGGTSFAYIENQRGGDRSYLNDWGQTTVQCLLNAQGLMDQVEILASGGVRHPLDMIKCFVLGARAVGLSRTVLELVEKYPTERVIAIVNGWKEELKIIMCALDCKTIKELKGVDYLLYGRLQQVN
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIR_DROPS
Sequence: MTEVDDGAELLFFDTFSHEDITDINLDLVQFPKPVFITQVRIIPLGARVQADFPGGVRLGATNPSKFDLEFFVNDLGMPGASAFENLGLLRYNQNDCIHLDCSREKIPTDGLVLRGWYSTITLAVYGILTNSVTQPIASPTLPCEPAGPEMCNLSTEAHNVLLQEEVLKDDWAEPIPTELLVPHKAVVVSDYEHDDIEYGLSREHQHYHQHVDEEQREMRRLRRSTHSTDRSPPPPPMRTHTHSESNEREYIRCSRDKGSRDWSRSPEYSSHRSRRKRSDRSRSDADEHKWPRTPPASIDSPIRPRSPDAMDYDDDDSRSHYKMQASRGYRHSSESLHRDRDDEERSGTPQEQFEPILSDDEIIGDDEEDEAEDVAAAAEYERELEFAAAVAPPAIDAFEPWQRPLLVYEGDLAAHLNKELETLRLLFKKLSLQTRCESVTAFSDEHGLSADEREQFVYLGEQLNNQLGYLSQHYKRRNFVLQQFFSHDDAHLRQAANVLQVALSFQAACMQPQPAFKIRHIKLGARMAELLGSNEQLFGHLLQEQDFDLFEAVLSLYKEPYMALSIKLQLLKAVYAMLDTRLGVQNFLSPKTNGYQMVMDFLKTAKLTRTKYALQAIIKKLHLYEALASVQQCCRQIFLDTDASVPETTPDPNRLDVCQKIEFAFQMLMDALTDSQLSYQQPRRFLPVSKKFEVLTDPTAQRSFGNALQSYFVQHSLAEALLVILSNPKEVPASTFLCTLDLMHTLLRSHVGIDYFVDDAFPVTQMIVSILLGLEEVPSQPRVVEAKPEGKEDKPMDDSVEQKPDEGKAAGIRAAEEPKMAPPPVVRKPILRPVLPRLARLGIELSYKVQTRYHLDAITFTAACPEYDTIKIATHMHSIYSQTCDPSGRQHTIEVLGLNNNLKIFMDLIKKEQRLQTQRQLLSSPGTKYKSPVLSYAVDMVDACVRYCEQLDYLIEHGGVILELAKNHETFEPSVSAVLQEMYVYMKPLEAINVFVYDDIMPLVEVIGRSLDYLTTFPGDLIMALRILRFLAISKPRQKSHGTEELKHRFVALQLYAADGVQLLLQIMERLCTHFEQPGIHAPALMTIQGVHCCQIMLPTLQILRELLSYAILCRDGTYKDLTAIDHLVKVYYLLYYYPSRCQAGAEVEQCKLEVVKSLLAYTQPHEQDAESLHKSLWTLMVREVLKNIDGPAHFIPGLKLLAELLPLPLPMPQPLCDQLKQQHKQRLIIERKLWSAHLHPQSGQIAKLVEALAPSSFPQLAELLQRVCMQLSDLAPNMTLLIAKTITELLCTEYQTSNCIPTTNLERLLRFSTRLCAFAPLKSSMLSILSGKFWELFQSLLALNEFNEVVTNCQEAVHRILDSFLDSGISLISHKSTAQPALNLSAALPPKELIPRIIDAVFSNLTSVEVTHGISILAVRNLVILTEHDFTFYHLAQLLKQKLTEFQAWMERVILHNETVEYHANIESLILLLRSLTQIEPPPPMCAMPNRTLKLGAMELAQLVEFQDIDMARPPVLARILRVLEKYKLLANEAALCDLKQLIVLHASRQEAMGSASMETPAVETENDGANPAASCSTSSSGGSLNVEPFLPQAEGIVTQYDARPIFTRYCATAENPQLTARYWLEPLPIELIEDMNEPLYERIACDLTDLANVCLNPDLATSGESKRTLNLSGSPQSNREMTPTAPCFRTRRVEVEPATGRPEKKMFLSSVRGRGFARPPPSRGDLFRSRPPNTSRPPSLHVDDFLALETCGAQPTGPTGYNKIPSMLRGSRVGRNRGSRISAAAAFRQKKMMRIGSPSSWTESGGGSYRSTSESHFGGSDSHYSSPHYSGRSRGRGLRSRPPYLR
What is the function of this protein?
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination.  Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy.  M6A methylation is also required for neuronal functions.  Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b.
What are the official names of this protein?
Protein virilizer.
What is the protein family that this protein belongs to?
Belongs to the vir family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PIWL4_RAT
Sequence: MSGRARVRARGITTGHSAREVERAPRDLMVTSVSPGDNEASSRTSVISQPHELGVSSGDGRRTLVEKRGNGRQDFVDLGVCTREKLTHVKDSKTGSSGIPVQLATNLFHLDLPQDWQLYQYHVTYSPDLASRRLRTALLYNHSILSDKAKAFDGTSLFLSEKLDHKVTELTSETQRGETVKITLTLTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIGRNYYKPSEPVEIPQYKLSLWPGFAISVSRFESKLLVNADVNYKVLRNETVLEFMTDLCLRTDMSCFTETCHKQLVGLIVLTRYNNKTYRIDDIDWSVKPTHAFQKRDGSETTYVDYYKQQYDITLSDLNQPVLVSLLKRRRNDNSEPQMVHLIPELCFLTGLTSQATSDFRLMKAVAEETRLSPMGRQQQLARLADDIQRNQVTRFELETWGLHFGSQLSLTGRVVPSEKILLQDHTCQPAFAADWSKDMRSCKVLSSEPLNTWLIVCCSRAEHLIESFLSCLRRVGGSTGFSVGHPKIIKVDENPAAFLRAIQLHVNPDVQLVMCILPSNQKNYYDSIKRYLSSDCPVPSQCVLTRTLNKQGMMLSVATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDICRDALSKDVAVVGFVASINSRITRWFSRCVLQRTAADIADCLKVCMTGALNKWYKHNHDLPARIIAYRDGVGNGQLKAVLEYEVPQLLSSVTECGSDARSCRLSVVVVRKRCLLRLFAESGHTLQNPPLGTVVDSEATRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGVISVPAPCQYAHKLTFLVAQSIHKEPSLELANKLFYL
What is the function of this protein?
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements.  Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association.  The piRNA process acts upstream of known mediators of DNA methylation.  Does not show endonuclease activity.  Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus.  In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities.  Plays a role in pancreatic beta cell function and insulin secretion (PubMed:28711973).  Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (By similarity).
What are the official names of this protein?
Piwi-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Piwi subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity).
Protein: RL27_BURM1
Sequence: MAHKKAGGSSRNGRDSESKRLGVKVYGGQAINAGGIIVRQRGTRMHAGENVGMGKDHTLFALVDGHVKFATKGADKKHTVIVVPAAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RK4_CYAM1
Sequence: MRCQVRLEIFYELNEQEQHMKHLLHRALRTHMLSIRQWGAHTKTRAEIRGGGRKPWKQKGTGRARAGSRRSPLWRGGGVAFGPRGVAMECKLNRKESRKATKIAFMACSKKIQIVNPPILEKPSSRTISQMLPPLPSRPVLWILHEKNPSLWLSCRNIKTLQLIQAEHIYVKPLLWAKQIWISHEAIPILENQLNVKMME
What is the function of this protein?
Probably binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRM1L_MOUSE
Sequence: MENMAEEELLPQEKEEAQVRVPTPAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDALEDDGTLGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINLAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDAPLMQFKSILLKYSTPTYTGAQSEGQMPPAAEDTVTDRVEMSVSDKAEASGCRRW
What is the function of this protein?
May play a role in motor coordination and exploratory behavior.
What are the official names of this protein?
TRMT1-like protein.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: FMT_CHLPB
Sequence: MRVIFMGTPLFAVPSLRAVAEADNDVEIVLVVTGKDKPRRSQRAEPEPTPVKKAAKELGLAVLEIDDVKDARFADTIARYRPDVIVVAAFRILPPAVYELARLGSFNLHASLLPRYRGAAPVNWTIINGDRETGVTTFFLGRKVDTGNIILQQRTPVAPEETAGELTERLADIGAGVVLKTLKRIRDGEAEPTIQDDAMATRAPKLTSETTRIDWAEPVDAICDFVRGLSPKPSAWTVFNHRKVKIYRVAPGMFQLPEQDEQQKVPGALVVDGTRMFVMALDGWVEILSLQMEGKRKMGAADFCCGFRCEEECPSFS
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: TVBT1_HUMAN
Sequence: MLLLLLLLGPGSGLGAVVSQHPSRVICKSGTSVKIECRSLDFQATTMFWYRQFPKQSLMLMATSNEGSKATYEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAR
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 20-1.
What are the subcellular locations of this protein?
Cell membrane.
Protein: P33MX_DANRE
Sequence: MVSRPGDLPALEAGPGSSEGLLGGMSIPAGMTRRALSYDDNLERPMSPPPSDINISNLWKRPVIPERKFARLAEEDESEGGVKQSASFESTKPIPVVKAKASSVMNSLIIKQTQESMQKFEKQAGLTDTGYTPHKGLNAEETRYHRLAESMHKLQMQSTDAKEERQPSSNQSTPAGTPQSSPKQKRRGWFNSQGSTASLTGSEMSTSSSSSVDLASAEGPIERWGVFGPRPQVSKSTTDPGTHPDTSGGFALQSYKGAQKPTPMEVMKAQATRLAEDPTNFKAPPKMEIPTMDGKRQVTRPHKLKHRDMNVLTPSGF
What is the function of this protein?
Potential NADPH-dependent oxidoreductase.
What are the official names of this protein?
Putative monooxygenase p33MONOX.
What is the protein family that this protein belongs to?
Belongs to the P33MONOX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_BORA1
Sequence: MANTPSQQDQFANKAQAWSARFSEPVSDLVKRYTASVDFDKRLARHDIRGSLAHADMLAAQGIISAQDLADIERGMQQILSEIDAGSFQWLLDLEDVHLNIEKRLVELVGDAGKRLHTGRSRNDQVATDIRLWLRDEIDLLIDLLRQLRHALATVALDNAGTIMPGFTHLQVAQPVTFGHHLLAYAEMFGRDAERLADCRKRVNRLPLGAAALAGTSYPIDRERVASTLGFDGVCRNSLDAVSDRDFAIEFCAAASLIMTHVSRLSEELVLWMSPRVGFIDLADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLVALLTLMKGQPLAYNKDNQEDKEGLFDTADTLRDTLTIFADMAGGIKVKADNMRAAALQGFATATDLADYLVKRGLPFRDAHEVVAHAVRDCEQRGCDLADLSLAELQAYHPSIEADIHQVLTLEGSVAARKHTGGTAPERVREEAQRVIQETA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_SALCH
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRSVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVAEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQFEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGSAIPEGAVDNAQLRDVNDAIRSHAIEQVGKKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: Y082_RICBR
Sequence: MSWIIFYTIIFALLVLDLGVIHKKNEVMSFKQSLLFSLFYFTISCLFGIYIYYNMGADSTREYYTCFLIEKAMSLDNIFVISIIFQFFKIPQKYQHRVLFFGIIGVIAFRAVMIYGGIILINKFSWLLYIFAVILIATGVKTFYVSHKTFDIQNSYLYKSIIKYLNVTPNLEGDKFFVTRNKKLYVTPLFISLILIEAIDLVFAIDSIPAIFAITNDAYIIYTSNIFAILGLRALFFCLAEIVERFSYIKYSLALILIFIGIKIFIHHYIAIPAYISLTVTITLLLLGIFASVIRKNIVDRQ
What are the official names of this protein?
Uncharacterized membrane protein RBE_0082.
What is the protein family that this protein belongs to?
Belongs to the TerC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NTPPA_YERPN
Sequence: MTALYLASASPRRRELLALLDLPFEVLKTEVEEQRHPGESAQVYVQRLAQDKARAGVAVAPQDLPVLGADTIVVLNGQVLEKPRDKEHAQQILSALSGQKHQVMTAVALADRQNMLSAMVVTDVTFRVLSPLEISDYIATGEPMDKAGAYGIQGKGGCFVRAIAGSYHAVVGLPLVETHELLSHFIAQRNVRGIHDS
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNT1_SCHPO
Sequence: MRTTLRLHIIKDGEQDNQFMILFDPSSSISLLKEKVQETYKSLYPFESNINIRNIKNEESYDIPNEYLVGEIFPTNSKVIVESFSSPLKKLDGTMINFKEKNIQHDLDGVENDFATVQSASNGVHAINGKRTHPDESENPRKLPKKNFVEAIDANSPGFVYRPTSIRDRAYSISSNHDNESTLTEGIALKEIESPDKDRKADGIVNLSVTQEEDDNHQSFNSSLTPSQPTTYNRANFFSINDASSDSSSDAPLRTLSSPSRLRMKDNDRKYLVEHSPAALIKESETIDGIDDKSLRSSTREVSVESPNEDSVNDDSSSDVSDEKETEAKHEIRAPAIIVRETSSHPSTAVPSENDTTESENDTLSESSTTSISSSPSENSDTSDDLTKVDSPNKSLVNDNVSAKHDKESENGKSKFPPPSQTLVTTSTISAAGNEPSDEIGSENDSDSDSDSDSSVPLSQLQKKSQQRNSVSHEIQNRGTKGSPKEPKAKPSTERPETHRTLSYSRLSELSKTFSPEIREPSLTKKTAVSMQESKEEGRSDESSESEESGSSSDESDNSEKEDRSNPIPVEKRASTVLNTKKKRKAKRNSALAGLAALV
What is the function of this protein?
Negatively regulates the septation initiation network (SIN) pathway, independently of the cdc14 phosphatase clp1.  May also have a role in silencing rDNA transcription.  Required for maintaining the exclusive nucleolus localization of nuc1.
What are the official names of this protein?
Nucleolar protein dnt1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Note=In late anaphase, localizes to the ends of the mitotic spindle.
Protein: PG074_MONPV
Sequence: MFMYPEFARKALSKLISKKLNIEKVSSKHQLVLLDYGLHGLLPKSLYLEAINSDILNVRFFPPEIINVTDIVKALQNSCRVDEYLKAVSLYHKNSLMVSGPNVVKLMIEYNLLTHSDLEWLINENVVKATYLLKINAYMINFKIDLTVDEIIDLVKDIPVGATLHLYNILNNIDLDIILRISDEYNIPPVHDILSKLTNEEMCIKLVTKYPMDNVINFINQDVRYSPTFIKTIKDFVNEHLPTMYDGLNDYLHSVIIDEDLIEEYKIKSVAMFNLEYKTDIDTLTLDEQIFVEVNISYYDFRYRQFADEFRDYIMIKERRQITMQSGDRIRRFRRPMSLRSTIIKKDTDSLEDILSHIDNAKKNSKVSIEDVERIISSFRLNPCVVRRTMLSDIDIKTKIMVLKIAKDWKSCTLTLSVKGIMVTDTINTVLSKILHHHRNIFKYLTSVENKEIAVCNCSRCLSLFYRKLKSVRCDLRTDDGLLDRLYDLTRYALHGKINQNLIGQRCWGPLTEILFNENKKKKLNNLMEYIKISDMLVYGHYIEKTLIPITDSLSFKLFVDTMSVLNDQYAKVVIFFNTIIEYIIATIYYRLTVLDNYTNVKHFVSKVLHTVMEACGVLFSHIKVNDKIEYELEEMVDKGTVPSYLYHLSINVISIILDDINGTR
What are the official names of this protein?
Protein OPG074.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG074 family.