PharMolix/UniProtQA huggingface dataset:
Protein: THIC_SHEWM
Sequence: MSNRRQTRAQAQQFIDTLTPLQHPNSEKVYLTGSREDLRVGMRQILQSDTLVGGTEADPILESNPPLKVYDCAGPYSDPDAEINVRAGLNKFRQSWIEERADTEQLAGVSSGFTQQRLADDGLDHLRFDSLLPPRRAQSGKRVTQLHYARNGIITPEMEYIAIRENMEQAGITDPVLRQKAKGESFGASIEQVITPEFVRQEVARGRAIIPLNINHPEAEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLSWEVFRDTLVEQAEQGVDYFTIHAGVLLRYVPMTAKRVTGIVSRGGSIMAKWCLSHHSENFLYEHFTEICELCAAYDVSLSLGDGMRPGSIADANDEAQFSELETLGELVKIAWEYDVQTIIEGPGHIPMNLIKENMDKQLALCDEAPFYTLGPQTTDIAPGYDHFTSGIGAAMIAWYGCAMLCYVTPKEHLGLPNKEDVKQGLIAYKIAAHAGDVAKGHPTAQIRDNALSKARFEFRWEDQYNLGLDPETARAYHDESLPQESAKVAHFCSMCGPKFCSMKISQEVRDYAASQEVELQSHASYQAKSASEIETGMAQMSAEFKAKGAELYHETAVVDEELADAEA
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: RL16_MYCS5
Sequence: MLQPKRTKYRKPFLQSHDKRKAHKGNKVSFGSHGLQAVTSAWVDSRQIESARIAATRSLGREGNVIIRIFPHFSKTSKPIGVRMGSGKGSPEKWYTPVKVNTVVFEIQGVSAERAKEALRLAGHKLPVKWKIIEKEGVN
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: DDX4_PELLE
Sequence: MSGQEDWESEIDNPPACVPNLSNSEPAFKASNQNYFSSNNAFNRTTERGFGNRKASDDCNQNFEFSERGFGKQRAGSDANQNFESSERGFGNRRGKGRGGFGTFGKDSNGKQESGDFTNDDNRTIDDNRRRGGFQRRGGFNDETSGRGRRGVRGGTSFSGFGREDGNEQSGFTSNDGFNNETSGFGSGRRGSRGDSSFSGDRESDRGRGFGRGGFRGRNEDIGVESGKGQEGFERSEQGPRVTYIPPPPPAEESDIFKHYQTGINFDKYDDIVVEVSGSDVPPAILTFEEANLCDSLAKNVCKSGYVKLTPIQKHSIPIIVAGRDLMACAQTGSGKTAAFLLPILAHLMVKGVESSAFQTLKEPEAIIVAPTRELINQIYLDARKFSYGTCVRPVVIYGGTQMFHSLKQISEGCNILCATPGRLLDVIRKEKIGLTKLRYLVLDEADRMLDMGFREDIENLLKSSGMPSKEERQTLMFSATFPSSIQSLAREILKPDYLFVVVGQVGGACSDVEQMVIEVDEFGKKDKLMEILQEIGSERTMVFVKTKKKADFIATFLCQEKVPSTSIHGDREQKERETALRDFRTGQCPVIVATSVAARGLDIENVSYVINFDIPDDIDEYVHRIGRTGRCGNTGRAISFFDKRGDDEQRIARSLVKVLSDAHQEVPAWLEEVAFSAHGSSAYNPRSNKFASTDDRKRGDSRGDYSTSGFSPSAAQAEEEDWG
What is the function of this protein?
Probable ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle.
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX4, DEAD box protein 4, Vasa homolog.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis.
Protein: DAPB_BURM9
Sequence: MSSMKIAIAGASGRMGRMLIEAVLAAPDATLAGALDRTGSSQLGQDAGAFLGKQTGVALTDDIERVCAEADYLIDFTRPEGTLAHLDAALRHDVKLVIGTTGFSEPQKAQLRAAGGKIALVFSANMSVGVNVTMKLLEFAAKQFAQGYDIEIIEAHHRHKVDAPSGTALMMGETIAAATGRTLDDCAVYGRHGVTGERDPSTIGFSAIRGGDIVGDHTVLFAGIGERIEITHKSASRVSYAQGALRAARFLAGHQAGFFDMQDVLGLR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSP2_CRODM
Sequence: VIGGDICNINEHNFLVALYE
What is the function of this protein?
Thrombin-like snake venom serine protease that coagulates human plasma and bovine fibrinogen by hydrolysis of the alpha chains (FGA) (minimum coagulation dose is 60 ug on fibrinogen).  Has fibrinogenolytic activities, and degrades preferentially the Aalpha chain (FGA).  Shows amidolytic activity toward N-benzoyl-L-Arg-p-nitroanilide, has a higher activity than Cdc SI.  In vivo, intravenous injection induces defibrin(ogen)ation and a loss of the righting reflex and opisthotoxins, together with a typical gyroxin-like effect (18-20 minutes).  Subcutaneous injection into the footpads induces moderate edema.  Potentiates local hemorrhagic activity induced by metalloproteinases (BaP1).
What are the official names of this protein?
Thrombin-like enzyme Cdc SII, SVTLE, Fibrinogen-clotting enzyme, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UNG_FOWPN
Sequence: MKTLKLNNWPYPIEYHEDWENIINHISDVIEETGPWLLEENTSPSHENIFKQLKQSLKDKRVCIVGIDPYPTDATGVPFESPDFSKKTIKAIAENISRRYNVRLFKNYNFLFVEGVLAWNYYLSCREGETKSHKIFWERLADVFINHIAAYVSVFYFLGKSDFSNFRSILNSPTTVVVGYHPAARNRQFDTDETFEIVNTLLELKNEPRINWVQGFEI
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.  Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity.  Binds to DNA (By similarity).
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
Protein: DAPT2_NOSS1
Sequence: MQFAKRLEKIPPYLFAEINRKREALIAKGVDIINIGVGDPDKPTPAHILQAMREAIDDASNHNYPPYEGTQEFREAAVEWMERRFGVMDLNPNTEVVSSIGSKEAIHNTFLAFVEAGDYTLIPDPGYPVYRTSTIFAGGEAFSMPLKAENKFLPDLDLIPEEVARKAKMLWINYPNNPTGALATLEFFEELVALCQQYSILLCHDHAYSEMAYDGYKPPSVLQIPGAKDIAIEFHSLSKSYNMTGWRIGFAVGNAYAIKGLSQVKTNVDSGVFKAIQKAAIAAYATDEVELQAVMSVYQSRRDIIVKGLQSLGWPIEPPKATLYVWVPVPPGYTSTEFTTLLLDKCGIVVPPGVGYGASGEGYFRVALTISDERLHEAIQRMQDAGIRYA
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase 2, DAP-AT 2, DAP-aminotransferase 2, LL-DAP-aminotransferase 2.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: NU4M_PROWI
Sequence: MNRNEISFIYYVKIKLYLYNSFFIMSYIEMVLAIPLLGAIALLFVPSWKTQTIRNIALNSSLLTFLISLLLWIEFDSSSALFQFTDGVCSPNVYSDVTLAKAASSSSFSALNFALGVDGISLFFIILTTLLVPICILVSWNNIEVYVKEYCIAFLVLETLMLTVFSVLDLLLFYIFFESVLIPMFIIIGVWGSRERKIRAAYQFFLYTLFGSVLMLLAILLIYFQTGTLDIEMLYLSDFSETRQCILWLAFFASFAVKVPMVPVHIWLPEAHVEAPTAGSVILAGILLKLGTYGFLRFSIPLFPYACIYFTPLIYTMSVIAIVYTSCTTIRQIDLKKIIAYSSVAHMNFVTIGLFSQNTQGIEGSILLMISHGLVSPALFLCVGVLYDRHKTRLLRYYSGCGQTMPIFALLFVFFTMANISLPGTSSFPGEFLVFIGSYQNNSFVAFCAATGMVLGAAYALWLCNRLIYGVSKPDFINTWSDVNRREFFMFAPLIAGILWIGVYPEPFLDAMHCSCIYLLYAQ
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: BCA1_SCHPO
Sequence: MSLMFLRRAGNIKGRNIRFALQRGSVGYSQQSSEACKNFLNTTQLRTMVQTAALHGPKPMDSSHIKVTNVKELKPLPEWKSLKFGENFTDHMLIMKWNREKGWSTPEIVPFGKLCFHPASSVFHYGFECFEGMKAFRDEKGVPRLFRPIKNAERMLSTGTRISLPSFDPAELAEIIRKFVAHENRWVPDQRGYSLYIRPTFIGTDEALGVHHCDNAMLYVIASPVGPYYSSGFKAVKLCCSEESVRAWPGGTGHYKLGGNYAPSVLPQKEAAKKGYAQILWLYGDEDYITEVGTMNCFTVWINKNGEKEIITAPLDGMILPGVTRDSILEICRERLAPKGWKITEGKYSMKEVAQASKEGRLLEVFGAGTAALVSPVKAINYKGTEYEIPMPEGQEAGPITSEISKWILDIQYGKEPNNPWSVPALP
What is the function of this protein?
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
What are the official names of this protein?
Branched-chain-amino-acid aminotransferase, mitochondrial, BCAT.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus. Cytoplasm.
Protein: CSRA_DESVH
Sequence: MLILTRKAGESLHLGDDIRITVLGIQGKQVKIGIEVPGDMVVYREEVYRRVIEENRMALDISNADLLAATKIWHGRTK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR13_GUITH
Sequence: MARISGIDLPKNKRIEIALTYIYGVGLSSSQKILEKANIDANKRCKDLDDNEVSLIRSIIDENYPVEGAAKRVESMNIKRLMEINCIRGKRHRVGLPLRGQRTRTNARTRRGAKKTVAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.
What are the official names of this protein?
30S ribosomal protein S13, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YTZD_BACSU
Sequence: MMKKEPERYIYDEQESQETTRLISEAYQSGYVDMPDQESSSPAE
What are the official names of this protein?
Uncharacterized protein YtzD.
Protein: GLPE_PSEE4
Sequence: MSEFKRISPEQALALRAEGAVVVDIRDPQAYAAGHITGATHLDNHSVADFIRNADLDAPTLVVCYHGNSSQSAAAYLVGQGFSNVYSIDGGFELWRSTYPGETAQGNAE
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMD3_RAT
Sequence: MSRLGALGGSRAGLGLLLGTAAGLGFLCVLYSQRWKRTQRHGRSQSLPNSLDYAQTSERGRQVTQLRAIPGEAGDAAMLSSLPQEGQEKVLDRLDFVLTSLMALRREVEELQRSLQGLAGEIVGEVRSHMEENQRVARRRRFPFARERSDSTGSSSVYFTASSGATLTDAESEGGYTTANAESDYERDSDKESEDAEDEVSCETVKMGRKDSLDLDMEVASSPASAALEDDDSSGLEDVQLLLQQADELHQGSEQNKQEGFQLLLNNKLAYGSRQDFLWRLARAYSDMTELTEEESEKKSYALNGKEEAEAALKKGDESAASHLWYAVLCGQLAEHEGISKRIQSGFSFKEHVDKAIELQPEDPRGHFLLGRWCYQVSHLSWLEKKTATALFESPLSATVQDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARKWLNLAQELPNITNEDSAFQKDLEELEVILGK
What is the function of this protein?
Involved in cellular calcium homeostasis regulation (By similarity).  May participate in differentiation and apoptosis of keratinocytes.  Overexpression induces apoptosis (By similarity).
What are the official names of this protein?
Regulator of microtubule dynamics protein 3, RMD-3, Protein FAM82A2, Protein FAM82C.
What is the protein family that this protein belongs to?
Belongs to the RMDN family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
Protein: RS11_MESM1
Sequence: MAVKKTKSKQKVKRKNIVSGVAHIHSTHQNTIVAFSDEAGNVFAWSSAGAIGYKGTKKKTPYAAGLATTAAVEKAKEHGLKEVRVELKGTGSGKDAARKQIEALGIIIKEVKDVTPIPHNGTRPPKKVLKRDLK
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: FABZ_HYDCU
Sequence: MLNVKEIFEYLPHRYPFLLVDRVTEFKSGESLKAYKNVTYNEPQFTGHFPDNPIMPGVMIIEAMAQCTGILAFKTQDVKPDGTSMYYLAAVDNCRFRKPAIPGDKLEFEVKTVNNKKGIWKFECTTSVDGKLIASCDMLCAERKV
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_PARD8
Sequence: MKDLKDLVRPNVWNLKPYSSARDEFHGDASVFLDANENPWNMPYNRYPDPLQWKLKDRLAVLKGVDRSSIFLGNGSDEAIDLVIRAFCEPGLDSVVTISPSYGMYEVAANVNNVECRKVSLDENFDLDAEAVLESADEWTKVIFLCSPNNPSGNSLDRGSIYKILKNYEGIVVIDEAYIDFSAYPSFLKELSGFPNLIVLQTLSKAWGAAGIRLGMAFASPEIIGVLNKIKYPYNVNQLTQEKALELLNDEATMKHQVNEILTERNRLEKILSEPPFSYQVYPSDANFLLVNVAKADAMYNGLVKKGIVVRNRSNVQKCRGCLRITIGTPKENDSLLNAMKNMKL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: STAR_DROME
Sequence: MSQQVFSAHPALAVDQLQQAEQEEHNTSSNHHQQRSATQSRRHTKAAPKKFTLSRSCAGGGSGTLSGVHQQVKPSPSNPAISPECRKTLPVRTNYAAVDDDDDIECEDVDEVNFGQQEKERERETRQPTKDCGTDETDHVQQRHKNTMTTSATAASRHHHQDGGGGDQSDLSSVISSPSVSTVSSPLSTPTRLPQALQQQLHCCQKSTGMESRARTSPQQIQHPHRQHHQQQHHHHHHHHHLTAAGCTGGGGGGGGSGGSGSCKAKKLDPRLNPSPYRQLLPIALCLLSFAAVFATLIVYMDTTEIRHQQFRLNMSRDYELNGVAQDDPALIDFLRQIHMGKYLGKASPKVAAAASVGVGPPPNSPRLAAAGSTFGSGNSSGSGADQLAHYVADLVGGKMNGAVIQSLSGPLAHLITAPWLSEQLNWMGVLVEPEPRWYFTLRKQNAQRARMQVVHACVSPNTYPKEITIHNEDVRINSLHDEETSWFNSRVKCFPLYTIMLACERTEYDLLSLGVQGHELEILQTLPFDKVKIDVISIHLLEDHEDVADYVLDITRFLAGKSYKLQRKIGRNYFYQRLNASASRTRKKDILLLKTP
What is the function of this protein?
Involved in EGF receptor signaling.  Has an early role in photoreceptor development.  Interacts with the receptor torpedo in the eye.
What are the official names of this protein?
Protein Star.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.
Protein: DCD_BUCAI
Sequence: MRLCDKDIEEWLERKELIIEPYPNKTLINGITVDIHLGNKFRFFYEHTGSCIDLSNSKIIGGLSLTEIMSNEIIFSKEQPCFLQPGSLVLCSTFESIKMPNNLVGWLDGRSSLARLGLMIHATAHRIDPGWNGNIVLEMFNAGKLTLVLRPKMRIAALSFEVLSQPVLRPYNLRKEAKYKIQNGVVPSRIHKE
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: PSRP_PSYCK
Sequence: MKALEVDNAQNIRTAFFISDGTAITAETLGRAILSQFASVPFETRVLPYVDNLERAEDAVVQINTAYQRDGLLPLVFDTIVSPEIREKINSAHSCNLDMYEGLIGRVAEETGVEPDGHSGHAHDNVDSETYKERIDAVHFALDNDDGARTRHYHAADIILIGVSRSGKTPTSLYLALQFGIRAANYPLTEEDLNDNQLPKALREHKHKLFGLIIDTDRLVKIRQERRAGSRYSSYQQCQQEQRAIQGIYTSQGIPSLDVSEMSVEEIATRILQMTGLKRRIG
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: RL17_VARPS
Sequence: MRHGHGLRKLNRTSSHRLAMLQNMMNSLIEHEVIKTTVPKAKELRRVIEPMITLAKKPTVANKRLAFDRLRDRDSVVKLFGELGPRFAARPGGYTRILKMGFRVGDNAPMALVELVDRPEIKEEAAEQGAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RFIP2_HUMAN
Sequence: MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPVWKEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVAINLNDIFEDKQRRKTEWFRLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKGRKNDGTFSDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLGPQRLSSAHSMSDLSGSHMSSEKLKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTLSFDTSKMNQPDSIVDEGELCFGRQNDPFTNVTASLPQKFATLPRKKNPFEESSETWDSSMNLFSKPIEIRKENKREKREKVSLFERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAFSENRQDYFDYESTNPFTAKFRASNIMPSSSFHMSPTSNEDLRKIPDSNPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKFSNS
What is the function of this protein?
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane.  Involved in insulin granule exocytosis.  Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles.  Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane.  Also acts as a regulator of cell polarity.  Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.
What are the official names of this protein?
Rab11 family-interacting protein 2, Rab11-FIP2, NRip11.
What are the subcellular locations of this protein?
Cell projection, phagocytic cup. Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.
Protein: VINC_CAEEL
Sequence: MPVFHTKTIENILEPVAQQLHYVLAMAEKNATSVDEVRHLGTSMPNLDRFASRSALALSRASSRRSIPEYITPDTVRHVVNDDDCPVCQLMMPRGKDGCVSRLVILHEEANDGNAMPDLTGPVGMVSRAVGNLIQVGYDTCDHSDDRILQQDMPPALQRVEGSSKLLEESSYSLKHDPYSVPARKKLIDGARGILQGTSALLLCFDESEVRKIIRVCRKANDYVAVSEVIESMADLQQFVKDISPVLHDVTNDVNLRQQELTHQVHREILIRCMDSIKVIAPILICSMKTSIELGTPHPRQGHAEAIANRNFMSQRMTEEMNEIIRVLQLTTYDEDEWDADNVTVMRKALSAAKSLLTAALDWLADPHARSGAVGEKAIRRICEYADRISARALPEDAQSIKRSIFEITSFTDELCNLRNNGQPDRENLAAQTARRLKDLVGSQNSSGLMGDALQNAQRHGGANPAHTAAGRLEQALRWLDNPGLDDGGLGLQALRLLTADARKLADRLNPQDRNRLLGLCSDIDRLAAQLADLERRGLGNSPEAHQIRNQLKNALRDLGDFMRRVLTDRVVDDFADITTPLKQFVEAVHADPYDPNREQNFVDKSQRLTDHSQSMTTTARLVASCGPSKSKKTVEAILDTAEKVEQLTPQLVNAGRVRLHNPGSEQHFENIHKQYADALHRLRSHVDDAIDTGEFVRASETAMRRYTNHCEGAINGADAHGLVNNSSQIARLGNRVLMTAQNEADNSEEPSFVSRVRNAADQLHNAIPPMVNNAKQIAQNPHDQYAAQNWRGTNDHLLNSVRAVGDAITGVPMSNGRHSSYQESISRASPYNPPPPSSQVIRSVNASPPTAPIIHNKMIIREDIPAPPRPPPPVELSPPPRPPPPPEYDEEEETRAFWERYPLPQASHQPMLAAAHNLHNELKQWSSQENDIVAAAKRMAILMARLSQLVRGEGGTKKDLINCSKAIADSSEEVTRLAVQLARLCTDIKMRTALLQVSERIPTIATQLKVLSTVKATMLGSANVIGPYGQPVEGSEEDDEAMQQLVHNAQNLMQSVKDVVRAAEAASIKIRTNSGLRLRWLRKPMWSNF
What is the function of this protein?
Involved in cell adhesion (PubMed:20385102).  May be involved in the attachment of the actin-based microfilaments to the plasma membrane (PubMed:17326220, PubMed:31411810).  Involved in ovulation (PubMed:17326220).
What are the official names of this protein?
Vinculin, P107B.
What is the protein family that this protein belongs to?
Belongs to the vinculin/alpha-catenin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cell junction, focal adhesion. Note=Cytoplasmic face of adhesion plaques (By similarity). In myoepithelial sheath cells, colocalizes in dense body-like structures with actin thin filaments and pat-3 (PubMed:17326220). In body wall muscles, localizes to integrin adhesion structures (M line and dense bodies) (PubMed:20385102). Requires unc-95 for the localization to nascent muscle attachments during embryogenesis (PubMed:20385102). Co-localizes with sorb-1 at dense bodies (PubMed:28978740).
Protein: TATB_NITMU
Sequence: MFDISFSEILVIAAVALIVIGPERLPKVARTLGHVFGWAQRYVNDVKSDIQREIELDELKKWKASVEETGRSIENSVHTELDKFRETVEAGAEASAMPPPTTAPAGESSPPQNSSPAPAEPAPPPVQSTKNSDPAGPGVNRERETAE
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PURL_BART1
Sequence: MNPCNNITITPEIIAQHGLKEDEYQRILTLIGREPTFTELGIFSAMWNEHCSYKSSKKWLKTLPTEGKCVIQGPGENAGVVDIGEGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGAPDHPRTRHLVSGVVSGIGGYSNSFGVPTVGGEVNFDKRYNGNILVNAFVAGIAKTDALFYSKAQGIGLPVVYLGAKTGRDGVGGATMASAEFDDSISEKRPTVQVGDPFTEKCLLEACLELMELGAVVAIQDMGAAGLTSSAVEMGAKGNLGIQLNLDTVPVREENMTAYEMMLSESQERMLMVLKPELEKQAAAIFHKWGLHFSIIGKTTDDLRFRVFHQGEEVVNLPIKELGDEAPVYDRPWSEPVKKTLLKAEDVKKVENLGDALLTLLNSADQSSRRWVYEQYDTLIQGNSLICPGSDAGVIRISNKSKRALAFSSDVTPRYCEADPYEGGKQAVAECWRNISTTGATPLAATDNLNFGNPEKPEIMGQLVFAIKGIGEACRILDFPIVSGNVSLYNETNGGAILPTPTIAGVGLLSDWSKMVTISGMQNGDHIILVGDCGSHLGQSIYARDILNIDAGAPPPVDLQLEKRHGQFVRDVIHNGFVHAAHDISDGGLAIALAEMVIKAGKGIKAKLSNKSPHHAELFGEDQGRYLLAVKPEALNNLKEYAQTHAVSLTELGQVEGDSLNIDGIFTLSVESLIQAYENWFPKFMGEE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.