PharMolix/UniProtQA huggingface dataset:
Protein: RUTC_SHIDS
Sequence: MPKSVIIPAGSSAPLAPFVPGTLADGVVYVSGTLAFDQHNNVLFADDPKAQTRHVLETIRKVIETAGGTMADVTFNSIFITDWKNYAAINEIYAEFFPGDKPARFCIQCGLVKPDALVEIATIAHIAK
What is the function of this protein?
Involved in pyrimidine catabolism.  Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously.  RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions.
What are the official names of this protein?
3-aminoacrylate deaminase RutC, 3-AA deaminase.
What is the protein family that this protein belongs to?
Belongs to the RutC family.
Protein: RS12_BORPD
Sequence: MPTISQLVRKPREVSVIKSKSPALENCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTNGYEVISYIGGEGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGSLDLQGVKDRKQARSKYGAKRPKKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: WDR37_XENLA
Sequence: MPTESGSWAAARQTKQKRKSHSLSIKRTNSSEQDRLGLQRDMLEGQDSKLPPSVRNTLLELFGQIEREFENLYLENLELRREIDTLNDRLAVEGQAIDGAELSKGQMKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAICQLVKDYVGHRDGLWDVSVTRTQPVVLGTASADHTALLWSIETGKCLIKYVGHAGSVNSIKFHPTEQIALTASGDQTAHIWRYMVQLPTPQPMADTSQISGEEEVDFSDKDENDGDGDASSDCPTVRVPLTALKSHQGVVIAADWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAVNRISVSVGQRIIALPHDNRQVRLFDISGVRLARLPRSNRQGHRRMVCCCAWSEDHPTCNLFSCGFDRQAIGWNINIPALLQEK
What are the official names of this protein?
WD repeat-containing protein 37.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DDA1_BOVIN
Sequence: MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLHQQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT
What is the function of this protein?
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.
What are the official names of this protein?
DET1- and DDB1-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the DDA1 family.
Protein: PXL2C_HUMAN
Sequence: MAAPAPVTRQVSGAAALVPAPSGPDSGQPLAAAVAELPVLDARGQRVPFGALFRERRAVVVFVRHFLCYICKEYVEDLAKIPRSFLQEANVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEIASSGQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFIHRDRNRLDHKPINSVLQLVGVQHVNFTNRPSVIHV
What is the function of this protein?
May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis.
What are the official names of this protein?
Peroxiredoxin-like 2C, AhpC/TSA antioxidant enzyme domain-containing protein 1, Thioredoxin-like protein AAED1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C subfamily.
Protein: HPRK_LEPCP
Sequence: MKPTVISADALFDAHRAALKWEWIAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRVQIVGRREVRYLQPGDASGDNPVELQEKRISRIVTLEPPVLVVADGCTPPDRLVAMCERADIPLFCTEDSAGHVIDVLRGYLSQHFAERTSRHGVFMDILGLGVLLTGESGLGKSELGLELISRGHGLVADDVVDLFRVSQAAIEGRCPELLRNLLEVRGIGLLDIRAIFGETAVRRKMRLKLIVHLVRKETLDRDFERLPYEPLFEDILGMPVRKVVIAVDAGRNLAVLVEAAVRNTVLQLRGIDTYRDFIQRHRDLMDSGDSGL
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: STAA_DICDI
Sequence: MRSILILLSLLLTIAFASASFPYQCGPYSCQFGQVCRIDNGVCNCIPINDCHEVSLSTKVVGTWVDGSRGNKRFTQYDITITNNLNTNIKQIYIATDYTLRLRDHSNTSIWNVNLLPNGILTLPSYQPSINAHASFTFGFILEGTQPANLNVLSVSF
What are the official names of this protein?
Stalk-specific protein A, DIF-inducible protein.
What are the subcellular locations of this protein?
Secreted.
Protein: LUXS_STRPZ
Sequence: MTKEVIVESFELDHTIVKAPYVRLISEEFGPKGDRITNFDVRLVQPNQNSIETAGLHTIEHLLAKLIRQRIDGMIDCSPFGCRTGFHLIMWGKHSSTDIAKVIKSSLEEIATGITWEDVPGTTLESCGNYKDHSLFAAKEWAQLIIDQGISDDPFSRHVI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: MECP2_RAT
Sequence: MVAGMLGLRKEKSEDQDLQGLKEKPLKFKKVKKDKKEDKEGKHEPLQPSAHHSAEPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPGKLLVKMPFQASPGGKGEGGGATTSAQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHAESPKAPMPLLPPPPPPEPQSSEDPISPPEPQDLSSSICKEEKMPRAGSLESDGCPKEPAKTQPMVAAAATTTTTTTTTVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
What is the function of this protein?
Chromosomal protein that binds to methylated DNA.  It can bind specifically to a single methyl-CpG pair.  It is not influenced by sequences flanking the methyl-CpGs.  Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.  Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
What are the official names of this protein?
Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci.
Protein: TES_MONDO
Sequence: MDLENKMKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVFMSNEEDRKVGKLFEDTKYTTLIAKLKTDGIPMYKRNVMILTNPVPAKKNVSINTVTYEWAPPVQNQALARRYMQMLPRNKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELTPNEVKQMEQFVKKYKNEALGVGDVKLPSEMDVKPGDRSSLDGGDRGTTAEVGAVEDKSSADKKEDYSCYCCKQSMKEGDPAVYAERAGYDKFWHPACFICNTCSELLVDMIYFWKNGKLFCGRHYCDSEKPRCAGCDELIFSNEYTQAEDQNWHLKHFCCFDCDSILAGEIYVMVDNKPICKPCYVRNHAVICQGCHNAIDPEVQRVTYNNFNWHATEECFLCSCCSKCLIGQKFIPIEAMLFCSVECKKMMMS
What is the function of this protein?
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton.  Plays a role in the regulation of cell proliferation.  May act as a tumor suppressor (By similarity).
What are the official names of this protein?
Testin.
What is the protein family that this protein belongs to?
Belongs to the prickle / espinas / testin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
Protein: SDHD_SERP5
Sequence: MEKTQIQQLVKQFPLVQELIELNPVTWFNPRATTLQAGLPFVGLDAADVADAEQRLARFAPYLSAAFPETRAANGVIESEVVALPAMQTALDQRYGLSLAGRLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALAAGLLQLTDDYAKLFSAEFREFFGGYRIAVGSTGNLGMSIGIISARLGFSVSVHMSADAREWKKQKLRDNGVNVVEYEQDYGVAVEQGRLQAASDPRCFFIDDENSQTLFLGYAVAGGRLRRQFAESGVQVDAQHPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCIFAEPTHSPCMLLGVHTGLHDGIAVQDLGIDNQTAADGLAVGRASGFVGRAMERLLSGFYTLSDREMFALLGLLDSHEHIQLEPSALAGMPGPWRVTADTEWLAAQGLNEQQMKNATHLVWATGGGMVPEAEMAKYLANARQSI
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: RPO10_THEON
Sequence: MIVPVRCFTCGKVIGDKYYEFKARVEKGEDPEKVLDDLGVERYCCRRTLLSHVELIDQVMVYKVY
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit N.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_GEMAT
Sequence: MSEVIIHEDENFERALKRFKKKCEKAGILSDLRKHRHYEKPSERRKRKMNAAVRKNRRTRHG
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: SAHH_XANOP
Sequence: MNAVTKITPHADYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTTPLKDVRITGSLHMTIQTAVLIETLKDIGANVRWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGSTWVDEPASSHEESVIKALLKRVAVERPGYWARVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLYGCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVVVTEIDPICALQASMEGFEVNTIESTLGRADIYVTTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKALKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATGHPSFVMSNSFANQTLAQIDLWEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVDVAGPYKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG20_GIBZE
Sequence: MWNDEDNNPYGTSFDRRDSQSSSINPTSPSTREYQRFEPPQTPTSDSDNEHNHGVIHDDSDDDDEDLTQDAGPKRKPGGYDSRIEQILYENPKLSILITDAGKSIESGGRYIVYTIKTGDLEVRRRYSEFASLRDALTRLHPTLIVPPIPEKHTMADYAANPTNAKQDQQIIDLRKRMLAVFLNRCRRMEEIRTDGVWWRFFDPNASWSEVLHSHPVASIPKSILKAPPLNPANPTPAHNYLPIPAASAKLKTVAGTNHDNSSGHIQAGPHAFGRFPPEGHNLGEQELDPYFISYESSIKDLEQLLTGPMEKVNRRTLSHLSSLAADLCELGSVYNAFAVSEQAPSLGPAIERIGQAADLSYIATEELSGSLGASFAEPMREHAQFAGVVRSVLKYRVLKRVQQDLTTEELSKKRALLDQLEQSEAEARRIENYLSSSQQISPPPKRSTSLREPPSHQRRDGSQEDTESIDSDFPGTHGDFSSHTPSASQGLPERSTSVPSHKKMPSGNSITNKIFGPIRHAVQGVVDVDPERTRRDLIGKTRESIGQLEQAQVVSEKDVKEASASVLKDMKRFQKDKEDDLRRYMLAYAQSQIEWAKKSKQQWEEARAEVEKIDES
What is the function of this protein?
Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy (By similarity).  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).  Functions in protein retrieval from the endocytic pathway.  Required for proper sorting of the v-SNARE protein SNC1 (By similarity).  Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236).  Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
What are the official names of this protein?
Autophagy-related protein 20.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: TX610_LYCSI
Sequence: MKLLLFTALVLVVISLIEVEAENERACIPLEKECTKTPGNCCSGLKCDCYRRFEQGVAKGIQCWCIEKDVTYKGI
What are the official names of this protein?
U6-lycotoxin-Ls1b, Toxin-like structure LSTX-F10.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 06 (U6-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CY552_SCHAZ
Sequence: TEQAAPAADDPEGMVKASCASCHGQNLEGGVGPALADVGSRNAMPAGMVDPAK
What are the official names of this protein?
Cytochrome c-552, Cytochrome c552.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: GAL1_THEKO
Sequence: MRVYSPGRVNLIGEHTDYSYGYVLPMAIDRYTVIEGEPHERVELYSEHFKKSVSFELEKLEKGNNWADYVKGVYWVLQREGYEVGGMKGRVGGNLPLGSGLSSSASFELAVLAFLNEAYSLKLSRLDMALLAKKAENEFVGVPCGILDQFAIAFGREGKAIFLDTETLDYEYLPFPEDLEVLVFYTGVKRELASSAYAERKKAIEEALRVLGKSSSKYVTEEELSKLPEKERRYLGYVVRENSRVLAFRDALKEGDVEAMGQLMVEAHRDIAENYRVSCEELDFFVEKALELGALGARLTGAGFGGSAIALVEHGKGESLGREVAELYTKVFPWTPEVFVVRPSEGVMVL
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_IGNH4
Sequence: MEVPAAWKKFRYRGKTLEELLEMPLDDFIELLPARQRRSLKRGFNDAQRRLLEKVLKARKEMEKGKKVKIRTHVRDMVILPIMVGLTIEVYNGKEFVPVKIVPEMIGHYLGEFSHTTAVVKHGEPGLKATRSSLFVAAK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: CEP2_ELHVK
Sequence: MSTSSEPYLEPLRLFLNKECIWRKTGKGAKHREYRCLSSSSPWSILPHQAARRVWKYEINIIIVKKRNDDYIISMAIEGLHYQQILCPKVLTQLFFILHSHGGTKFYKLTFDPFKPMNAELAVPLYDTTPLPHMTMQGLSVYDHCSVVGKPICAQVAGSITQIGTCGVWAVTTGAQTNIVCFALRYDLAVCISDPKVFPSMARCMASAVGCAQETCSYCTGHNKHVEVFDVNGDYGKNKELCFCSTPCGDWDFRDESMKPLFSKNDDMVGIRVREPPNSENTIFSKASAYFYGITRDGKEVDLSDENFILLKIDPRLSHMIIVACPILKRMCMIKS
What is the function of this protein?
Plays a critical role in cytoplasmic virus egress.  Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid.  Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.
What are the official names of this protein?
Cytoplasmic envelopment protein 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Note=Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.
Protein: GLYA_STAAN
Sequence: MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLSHGGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALEHKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKEEYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDNHLVAVDVKGSIGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLGTPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKERVAKLTAEYPLYQ
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_CHLPB
Sequence: MAIRKLGPVTPASRYLSYSKFEEVTKSTPEKSLLAPLKKSGGRNRAGRITSRHKGGGHKRFYRIIDFKRSKDNIPAKVAAIEYDPNRSSRIALLHYADGEKRYILAPKGLKVGDVLHSGDKVDIKVGNSMPLKNIPLGADVHNIELKQGKGGQMARSAGAFATLAAKEGDHATLKLPSGEIRKVRIECRATIGGIGNDDHENIVLGKAGRSRWLGIRPQTRGMAMNPVDHPMGGGEGRSKSGGGRKHPKSPWGQLAKGLKTRNKKKASSKLIVRGRKAK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: S19A2_MOUSE
Sequence: MDVPARVSRRAAAAAARMLLRTARVPRECWFLPTALLCAYGFFANLRPSEPFLTPYLLGPDKNLTERQVYNEIYPVWTYSYLLLLFPVFLATDYLRYKPVILLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYTVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVVGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSSCHGVNGLKVQNGGIVTDTPAANHLPGWEDIESKIPLNLDEPPVEEPEEPKPDRLRVFRVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYAQGLWEKVMPSQNADIYNGGVEAVSTLLGASAVFAVGYIKLSWSTWGEMTLFLCSLLIAAAVYVMDTVQSIWVCYASYVVFRIIYMVLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDARGLGLCITTQFLIYASYFAAISVVFLANGIVSIIKKCRKQEDPSSSPQASTS
What is the function of this protein?
High-affinity transporter for the intake of thiamine (PubMed:11481326, PubMed:11592824, PubMed:12393806, PubMed:22194418, PubMed:12031504, PubMed:24961373).  Essential for spermatogenesis (PubMed:14567973, PubMed:14738878).
What are the official names of this protein?
Thiamine transporter 1, ThTr-1, Solute carrier family 19 member 2.
What is the protein family that this protein belongs to?
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MED23_MOUSE
Sequence: METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWSGLSQESHEQCVQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKAILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNGDSTLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYKVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVNVISSSSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEALLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAVPPQALNSGSPAPQSNQVPASLPVTQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity).  Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex.  Required for transcriptional activation by adenovirus E1A protein.  Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 23, Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subunit 3, Mediator complex subunit 23, Protein sur-2 homolog, mSur-2.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 23 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: URED_AGRFC
Sequence: MQSEQQAIGASGCEDAQQPVRQQRARGRGRIVTKAVEGRSRLDELFQEGCAKIRLPDTFSNEAEAILINSSGGLTGGDDIEWQATAGAGTSLVVTTQACEKVYKASSGTATVTARISAGPGAKLHWLPQETILFDRASLNRRLEADLDQSSEFIAVEAVLLGRQAMGEAMTHGLFRDRWRIRHGGRLVHAEELLLEGEVAELTAKPAVLAGQVAFATLLYIGPLSEALLPKIRAIAGESGGASEWQGKLVVRVSAADGFSLRKLLFPIISLLRNGAPVPKVWNL
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PER_DROAN
Sequence: EGSGGSGSSGNFTTGSNVHMSSVTNTSNAGTGGTGTNTGTNTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGKGAGAGTGTATNETAGPGTTTTTTTRSTTTAATAASPPVTLTESLLNK
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
What are the official names of this protein?
Period circadian protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).