PharMolix/UniProtQA huggingface dataset:
Protein: UBC9_SCHPO
Sequence: MSSLCKTRLQEERKQWRRDHPFGFYAKPCKSSDGGLDLMNWKVGIPGKPKTSWEGGLYKLTMAFPEEYPTRPPKCRFTPPLFHPNVYPSGTVCLSILNEEEGWKPAITIKQILLGIQDLLDDPNIASPAQTEAYTMFKKDKVEYEKRVRAQARENAP
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins.  Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis.  This may be as part of a checkpoint independent recovery process.
What are the official names of this protein?
SUMO-conjugating enzyme ubc9, Ubiquitin carrier protein 9, Ubiquitin carrier protein hus5, Ubiquitin-conjugating enzyme E2-18 kDa.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATP6_MOUSE
Sequence: MNENLFASFITPTMMGFPIVVAIIMFPSILFPSSKRLINNRLHSFQHWLVKLIIKQMMLIHTPKGRTWTLMIVSLIMFIGSTNLLGLLPHTFTPTTQLSMNLSMAIPLWAGAVITGFRHKLKSSLAHFLPQGTPISLIPMLIIIETISLFIQPMALAVRLTANITAGHLLMHLIGGATLVLMNISPPTATITFIILLLLTILEFAVALIQAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MCRI2_MOUSE
Sequence: MYTITKGPSKLVAQRRTGPTQQQVESRLGELLKCRQPVPPTALPAHLQPSAQTQGPWPLASSGPRLVFNRVNGRRPLTTSPSLEGTQETYTVAHEENVRFVSEAWQQVERQLDGGPADESGPRPVQYVESTPDPRLQNFVPIDLDEWWAQQFLAKITNCS
What are the official names of this protein?
MAPK regulated corepressor interacting protein 2, Protein FAM195A.
What is the protein family that this protein belongs to?
Belongs to the MCRIP family.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule. Nucleus. Note=Upon cellular stress, relocalizes to stress granules.
Protein: RECA_RICCN
Sequence: MSNTDKERAIAAALAQIEKSYGKGSVMKLGQRPHVDIEAVSTGSLGLDIALGIGGVPKGRIIEIFGPESSGKTTLTLHLIAEAQKKGGTCAFIDAEHALDPAYAKKLGVNIDELIISQPDTGEQALEIADTLIRSSGIDMIIIDSVAALVPKSEIEGEMGDAQMASQARLMSQALRKLTASINRTNCITVFINQIRMKIGVMFGSPETTTGGNALKFYASVRIDIRRIGSIKDKEEVIGSQTKVKVVKNKVSPPFKTADFDIMYGSGISKEGEIIDLGVKLDIVEKSGSWFSYKNVRIGQGRENVKQYLKEHPQISNEIEKIIREKSSKITNINLDQTEEEND
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_SOLUE
Sequence: MPKAKISALGCYTPPRVLTNQDLEKLVDTNDQWIMERTGIRERHIAAPEMATSDMAIEAARCALLQRGIDACEIDAIILCTVTPDHLFPSTACLVQNAIGAKGAWGFDLIAACSGFLYGLTTGAHFVMAGTHKKVLVIGSDTMSRIIDYTDRATCVLFGDGAGAMLIEATDEADDGTGFIDFLGEIDGSGGEFLRMPAGGSRRPASHETVDQRMHYVHQEGSQVFKYASRKMYEVCRDLLERNHFKVEDVGLMIPHQANKRIIKAAGDRLGIAPERVMINIERYGNTTAGTLPLATRDAISEGRLKKGDLVLFAAVGAGYTVGASLWRWAF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_SHESR
Sequence: MTSYTFTRELRLLTPAQFKSVFSNPIKASSAEITLLAIPNSEQHPRLGLTVAKRYVKRANQRNRIKRVIRDSFRLNQHDIPHLDIVVLVRNGVMEMENAEINKLIEKLWRKLSRRYNG
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: TAL_BORPD
Sequence: MSSQLEALRRHTTVVADTGDFEAMRALRPTDATTNPSLILKAVQKEAYRPLLQQVVRDHRGAPLAELTDRLLVAFGREILNIVPGRVSTEVDARLSFDTRATVERGRGLIALYEAAGIPRERVLIKTASTWEGIQAARLLQADGIRCNLTLLFSLPQAVACADAGVQLISPFVGRIYDWYKKAAGADWVEAERAGANDPGVQSVTEIYRYYKRHGITTEIMGASFRNKGQILALAGCDLLTISPELLAELDGAQGDVPVRLTRDDEAGEVPARRPADEVWFRTELNANAMATEKLAEGIRLFSADAIKLDALLGGAAGR
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_SALCH
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSNPASQIYVASKRKACDEVGFVSRSYDLPETTSEAELLALIDTLNADNTIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKDLRHHVEHADLLIVAVGKPGFIPGEWIKEGAIVIDVGINRLENGKVVGDVVFDEAAARASYITPVPGGVGPMTVATLIENTLQACIEYHDPQGK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: IXTPA_BORPE
Sequence: MSAEILNPNLRRVVLASNNAGKLREFSALFAPLGIELVPQSELGVSEAEEPHATFVENALAKARHASRHTGLPALADDSGLCVVALGGAPGVHSARYAQQPGGARSDAANNALLVRELAAAGDRRAWYVALLALVRTENDPCPLIGEGLWHGEIVDAPAGEHGFGYDPHFYLPQQGCTAAQLAPEHKNRISHRAQALAQLLDKLRATGPVDRP
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: SELO_BACCQ
Sequence: MTKNNEAGWNLDHSYTTLPQSFYTEIPPTPVSSPELVKLNHSLAISLGFNPEELKKEAEIAIFAGNALPEGAHPLAQAYAGHQFGHFNMLGDGRALLIGEQMTPAGKRFDIQLKGSGPTPYSRRGDGRAALGPMLREYIISEAMYALDIPTTRSLAVVTTGEPTYRETKLPGAILTRVASSHIRVGTFQYAAARGSIEDLQSLADYTIKRHYPEIEDHENRYTALLQEVIKRQASLIAKWQLVGFIHGVMNTDNITISGETIDYGPCAFMDNYDQGTVFSSIDTQGRYAYGNQPYMAAWDLARLAESLIPILHEDEEEALKIAQDEISKFSVQYENQWFLGMKKKLGLFSNEEQDQSLIEQLLKMMEKFKADYTNTFRSLTLNTLENTPLFDSPEFKEWYKLWQSRLEKQDESKENAYEMMKNNNPSIIPRNHRVEEALEAAVTSGDYSVMEKLLEALANPYAYTTDQEEYCVPPAPTNRPYRTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: TATA_OLEA2
Sequence: MFGIGIPELLVIFVLILLVFGAKRLPEIGGGLGRAIKNFKKATTEPDEIDVTPSSEKKHKDE
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AMPA_BURCH
Sequence: MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLHEVSGIGASRVLLVGLGKQDAFNQKAYNDAATTAWRALLATKVVQVTFSLAQLPVDERSSDWGVRAAILALRNETYRFTQMKSKPEPASHTLKRVVFSVDPADEKAAKVAIKQAVALANGMDLTRDLGNLPGNVCTPIYLGNTAKKIAKDWGLKAEVLGLKQIQALKMGSFLSVARASVEPPQFIVLHYQGAAAKAAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTMRAVAEMGLKINVVAIVPTCENMPGGNATKPGDIVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDVATLTGACVIALGGHNSGLFSTNDALAGELLDASREANDPAWRMPLDDEYQDQLKSNFADLANIGGRPAGAVTAACFLSRFTESYPWAHLDIAGTAWKGGAAKGATGRPVPLLAQFLIDRAGQ
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_RHOJR
Sequence: MKVQPSVKKICEKCKVIRRNGRVMVICENLRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: MIAB_GEOSL
Sequence: MTENKYLYVETFGCQMNVNDSEKIATLLKDEGYLPTDDPERADLVILNTCSVRAKAEQKVYGHLGRFKGVRSRKKGFLLGVGGCVAQQEGERLLQKVPWLDLVFGTHNLHLLPEIVRAAERGERRAEVGFIDNETRLDLFPETGGEGGVTRFVTVMQGCDNFCSYCIVPYVRGREISRRSSDIIDEVRKSVAEGVKEVTLLGQNVNSYGLKTEGELSFAGLIRRIAEVEGLERIRFTTSHPKDISPELIACFAEVPKLCGHIHLPAQSGSDAVLARMNRGYTRAGYLEKVEALRAARPGIQFTGDMIVGFPGETEEDFQATISLMEEVRYADLFSFIYSPRPETAAAGIRDTVSRKEKQSRLDRLQTLQQQMKRERNISFVGTRQLVLVEGVSKRGDQLYGRIDGNRIVNFAADQSLIGTMAEVTITQDYQNSLLGEIVTDKGDAR
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_IDILO
Sequence: MSISPAIDQLVENLKRLPGVGQKSAQRMAFHLLERDRGGASRLAESLQSAVEKVGHCECCRTLTEEPLCRICSNPMRRENGVLCIVETPADVLAIEQTSQFQGRYFVLMGHLSPLDGIGPADIGLDELERQLQSEPVEEIVLATNPTVEGDATAHYIADIAAQLNINTTRIAHGVPVGGELGYVDQTTLGHAFSGRKQFSR
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: ZRAR_KLEOX
Sequence: MSGEQVDILVVDDDISHCTILQALLRGWGYRVALANNGLQALEKVREKVFDLVLCDIRMAEMDGIETLKEIKTFNPSIPVLIMTAYSSVDTAVEALKSGALDYLIKPLDFDKLQLTLSEALAHTRLSESPVTETPAAQFGMVGDSPAMRALLNNITLVAPSDATVLIHGESGTGKELVARALHASSARSRRPLVILNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLDEIGDISPLMQVRLLRAIQEREVQRVGSNQTLSVDVRLIAATHRDLAEEVSAGRFRQDLYYRLNVVTIDMPPLRHRREDIPPLARYFLQRYAERNRKAVQGFTPQAMDLLIHYAWPGNIRELENAVERAVVLLTGEYISERELPLAITGTPVADAPHGDDSIQPLVEVEKEAILAALERTGGNKTEAARRLGITRKTLLAKLSR
What is the function of this protein?
Member of the two-component regulatory system ZraS/ZraR.  When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP.  Positively autoregulates the expression of the zraSR operon (By similarity).
What are the official names of this protein?
Transcriptional regulatory protein ZraR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRC19_MOUSE
Sequence: MKVTRFMFWLFSMLLPSVKSQASETEVPCNFSRRNYTLIPEGISTNVTILDLSYNRITLNAADSRVLQMYSLLTELYLMENNIIALYNSSFRNLLNLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLIRLFDAPQLPHLEILTLDGNPWNCTCGLLELHNWLNTSNVTLENENMTMCSYPDELKHDSIKSAPFTTECHSTFISTITEDFQSTRNSSFNSSSHNLTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSEDTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK
What is the function of this protein?
Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:26776522, PubMed:19679103, PubMed:25026888).  In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances (PubMed:25026888).  In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (PubMed:26776522).
What are the official names of this protein?
Leucine-rich repeat-containing protein 19.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: INSN1_ECOLI
Sequence: MICSPQNNTGVIMKKRNFSAEFKRESAQLVVDQNYTVADAASAMDVGLSTMTRWVKQLRDERQGKTPKASPITPEQIEIRELRKKLQRIEMENEILKKATVDSIGQRNSYVKTWGCGGFLNETNIYSRGKSLCF
What is the function of this protein?
Involved in the transposition of the insertion sequence IS911.
What are the official names of this protein?
Putative transposase InsN for insertion sequence element IS911A.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: CKL5_ARATH
Sequence: MEPRVGNKFRLGRKIGSGSFGEIYLGTDVQTNEEVAIKLESVKTAHPQLSYESRIYRVLQGGTGIPNMKWYGVEGDYNVLVMDLLGPSLEDLFSYCKRQFSLKTVLMLADQMINRLEFIHSKSYLHRDIKPDNFLMGLGRRANQVYIIDYGLAKKYRDSSTHRHIPYRENKSLIGTPRYASLNTHLGIEQSRRDDIESLGYILMYFLKGSLPWQGLKAGNKKQKYDKISEKKVSTSIETLCRGHPTEFASYFHYCRSLRFDDKPDYAYLKRLFRNLFIREGFQFDFVFDWTVYKYQQSQSGNPQPRPHDGGVGTSSGLNPAVGNSEKRPDVPNQRTNPDFTLKQKDKNGNDSAIAKDKLLPGSLNLGRSEGSSSRRVVDTSSREPFSGGSDNANYETALKGIDGLRINNNAGDETAATPQSNGDDVEPQSKAL
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  It can phosphorylate a large number of proteins.
What are the official names of this protein?
Casein kinase 1-like protein 5, Protein CASEIN KINASE I-LIKE 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_BACAC
Sequence: MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKLHFSVEAEDIHLNIEKMLMEKIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIIKAIKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGFNGIYENSLDAVSDRDFILEFLSNSSMLMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMAGMLETMTVNKEKMGQAVTQDFSNATEIADYLANKGLPFRQAHEIVGKLVLHCTQKGIYLIDVPLATYKEMSALFEEDLYEVLSPYAAVKRRNSAGGTGFEQIEKALEKAKGLTKEAIKN
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V204_FOWPN
Sequence: MFAISVLKELYDSGEPLLFSPRGLHKILCNIRHGCNGNTKNQLDNLLEETIYDYGEDQALKHIITNISVLLIKRCYNINEKFIKDSNTIYNTDVLEFYNVRQIPRIMNKWIRSRSNNKITDIGCHIYDNTKSIIAEAMFFTMKHESIFGSTRKDTITFYKYDGTSLPVEAIHADPYYYPYRYFDDIKCSVLQLWKLGYAFNMFIILPDDEKGLDNLVDNITGDVFSKIMTEQMDYKRLELRMPVFSISQETNFCMPIFNLGCHSMFIDGDFSGISEVSDFQLSGIIQKNIIEVQYDKVKTTKPLNVRCSSFYVNKPFIFIVTDVGNYDTIPILLGIYQGSSK
What are the official names of this protein?
Uncharacterized serpin-like protein FPV204.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Poxviruses subfamily.
Protein: ATPD_LIMRD
Sequence: MSLDKKTVADRYAKALFELVDADNELDQTYQELIALRQVFEDNEGLDAALAGVQLSLDEKKSLIKDLQQGASKYVANLIQMVFDYGRIDCMVAIIDEFERRYDRKMKRMHADVTTAIQLDKQQEDQLKANLAKRFGANEVTLTKHVDPEILGGVIVHVDNKTLDGSLSSKIKQIRRLLVR
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DNLJ_SULAA
Sequence: MYSEETQRKLIEKTREFLNLDIKSIDRKKAESIIEDLREVIRFHDWRYYVLAQPVISDYEYDKLFKLLKDIESKYPDLITPDSPTQRVPSEITKVFPQVKHLTPMLSLDNSYNEADLRDFDRRVRELTGLEKIEYAVEPKFDGAGISLIYEKDLFKRGATRGDGEVGEDITNNLKVIKSIPLSAKFSSYGIDKVEIRGEVLIRKDIFKRINEQRLEEGLPLFANPRNAAAGSIRLQDPKEVAKRGLEAFVYQITYAEKDGKNLLGTVLKKHSDNIKMLHLLGFKTPYEVLKVCNGIDEVIDYCREWERKRDNYPYEIDGMVIKVNDISLYEKLGFTSHHPRWAIAYKFKARQATTKIIDVVFQVGRTGAITPVAKLQPVEIGGVIVSSVSLFNEDFIREKDIRIGDTVLVERAGDVIPYVVMVIKEARTGNEKPIEFPKNCPSCGSPLVKPLGEAVYRCININCPAQVIERIIHFASKDAMDIKGLSEATVKKFYKLGLLKSIPDIYRLDFRIIKNIQGFGEKSVNNLKQAIEESKNRPLYRLIYGLGIRYVGEVTAKTLASAVNCLEDLKNFTITDLMKLPDIGDKVATEIYNFFHNEQNLKMIQQLKELGVNVCNPKEEKRGKLAGLNFVFTGALKCCSREKAKEIVESLGGNVLDTVSKKVHYLVVGEEPGSKLQKAQKIPTIKIINEEEFLKMIGQQ
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: SSH4_COCIM
Sequence: MFSRDDLVTTLTTSLIQGTPAPSSQSSIHRRFGSFQQATEPVNHGYRPSRVSASEKSIMFSLGGNVGSTGKGILIGILSALGSAGIAIIVLSLVFFLRYTHRGRIILDRLGRPGEYDDEQAFAREEAEALESMDELQQAEYMRAKAFIQANPPESAQTDISLSQFLAIQEKGVSAWEFEPELEIANCFVEARTEIEFFDSECSVQSNLPVPKQNEVYYWEAKIYDKPETSLISIGMTTKPYPLFRLPGFHKTSISYQSTGHRRHNQPFTPTLYGPEFVQGDVVGVGYRPRSGTIFFTRNGKKLEDVAHGLKSQNFFPTVGANGPCTVHVNFGQLGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLETGRENSQTPQWWGSAHSRTRSGTIRLGQGGPVRSPTDISLAPLPHISPPHDVGEGTSNSAQAGENDSDVDAAILDQPPPEYSSPATSPPNGQSGDARIDIHPDPNDPPIPSYDAAVLQQQQQV
What is the function of this protein?
Components of the endosome-vacuole trafficking pathway that regulates nutrient transport.  May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
What are the official names of this protein?
Protein SSH4.
What is the protein family that this protein belongs to?
Belongs to the SSH4 family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Protein: YPFN_SALG2
Sequence: MDWLAKYWWILVLVFLVGVLLNVIKDLKRIDHKKFLANKPELPPHRDFNDKWDDEEDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: COMB_STRPN
Sequence: MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQNETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKVTASEDGVLHLNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKYVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEKGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
What is the function of this protein?
Required for induction of competence.
What are the official names of this protein?
Transport protein ComB.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SHH_CHICK
Sequence: MVEMLLLTRILLVGFICALLVSSGLTCGPGRGIGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEHGGTKLVKDLSPGDRVLAADADGRLLYSDFLTFLDRMDSSRKLFYVIETRQPRARLLLTAAHLLFVAPQHNQSEATGSTSGQALFASNVKPGQRVYVLGEGGQQLLPASVHSVSLREEASGAYAPLTAQGTILINRVLASCYAVIEEHSWAHWAFAPFRLAQGLLAALCPDGAIPTAATTTTGIHWYSRLLYRIGSWVLDGDALHPLGMVAPAS
What is the function of this protein?
The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development.  Induces ventral cell fate in the neural tube and somites (PubMed:7736596).  Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity).  Essential for axon guidance (By similarity).  Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity).  In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (By similarity).
What are the official names of this protein?
Sonic hedgehog protein, SHH, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhNC.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Sonic hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Co-localizes with HHAT in the ER and Golgi membrane. SUBCELLULAR LOCATION: [Sonic hedgehog protein N-product]: Cell membrane; Lipid-anchor. Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (By similarity). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides.