PharMolix/UniProtQA huggingface dataset:
Protein: SNX6_PONAB
Sequence: MMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
What is the function of this protein?
Involved in several stages of intracellular trafficking.  Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable).  Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC).  Does not have in vitro vesicle-to-membrane remodeling activity.  Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R.  May function as link between transport vesicles and dynactin.  Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network.  Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation.  In association with GIT1 involved in EGFR degradation.  Promotes lysosomal degradation of CDKN1B.  May contribute to transcription regulation (By similarity).
What are the official names of this protein?
Sorting nexin-6.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (By similarity). Only a minor proportion is seen in the nucleus (By similarity).
Protein: PFS2_CRYNB
Sequence: MTAPTVPADQHGHPLPGPADPAANDTWRPSRYREPLHPDNEEVLEQAAYQAAVTRSSGDDRKRKIKPRRTVDYQGGVQKWRMLNKLKGVHEFRPAIHPNPSDIVNFLPPVALRSNPSTSICDYWVHTSINKERSPTRVVRWTPDARRLLTGNDKGQFTLWNGASFNYESITQVHDDSIRSFTYSHNGQALVSADKGGTIKYFTPHLTNIHGFQGHREACHDVSWSPNDERFVTCGDDGLVKIWSYREAKEERSLSGHGWDVRCVDWHPTKGLIVSGSKDMLVKFWDPRTGKDLSTLHSSKSTINTCRWSPDGHLVATAGQDSVIRLFDIRTFRELEVLKGHEKEVNCIEWHPIHHSLLVSGDALGTINYFSLLSPTPSTPITTLSAAHEDAVFSLSFHPLGHILCSGSKDFTARFWCRARPPGGQEFDKWHLTEEGAAQKELERITKREWGTNALPANAAGGGGGGGGGDKQQVALPGLSNLVAAVNSVKTGPTTTGGGPPGLPGLGAPNVHAGTPPSRVSTPSSMGPPGAGAQGQAQGGQFPRGRAALPSQNDMLRHNHGPRGGFADRDRNGGGDRGGMDRDRDSRGGRQDPRGNQMYGRGPGGPPPGPPPGQGGYNYPPAPPNYPPYPPSSYPPPPNNQPGYPPAPNYAMPPGPGAPPQSYPYNRPPQGPPQNNNPGGQGNYGASASGGYGQYGGGGGGGGGGGYGRDGRR
What is the function of this protein?
Required for 3'-end cleavage and polyadenylation of pre-mRNAs.  Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).
What are the official names of this protein?
Polyadenylation factor subunit 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNPH_CORGB
Sequence: MTSSSSFSRFDGRAQDQMRAVKITRGFTSNPAGSVLVEFGNTRVMCTASVELGVPRFKRDSGEGWLTAEYAMLPAATAERNRRESMAGKVKGRTHEISRLIGRSLRAAVDLSQLGENTIAIDCDVLQADGGTRTASITGAYVALADAIKVLQERGVVPGSPLLAPVAAVSVGLVDGNVCLDLPYEEDSRADVDLNVVMTEHGEFVEIQGTGEETTFTRAQLNDMLDYAEKGCRELVAAQKAALGI
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: ILVD_LEPCP
Sequence: MSFNRRSKNITEGVARAPNRSMYYALGYQQDDFSKPMIGVANGHSTITPCNSGLQKLADAAVIGIKEAGGNPQIFGTPTISDGMAMGTEGMKYSLVSREVIADCVETCVGGQWMDGVIVIGGCDKNMPGGMMGMLRANVPALYVYGGTILPGKYKGQDLNIVSVFEAVGQFSAGKMAEEDFCEIERRAIPGSGSCGGMYTANTMSSSFEALGMSLPYSSTMANVEEEIVASVKVAAGVLVEAVKADLKPRDIVTKKAIENAVAVIMATGGSTNAVLHFLAIAHAAEVEWTIDDFERVRRRTPVLCDLKPSGKYLAIDLHHAGGIPAVMKELLKHGLLHGDCMTITGKTVAENLADVPDLRADQDVIRAVTNPIYAEGHLAILKGNLSPEGCVAKITGLKSPVMTGPARVFEDEQSALAAIMANKIVAGDVMVLRYLGPKGGPGMPEMLAPTGALIGQGLGESVGLITDGRFSGGTWGMVVGHVAPEAYAGGNIALVQEGDSITIDAHQLLLQLNVSDDELARRRAAWTAPAPRYTRGVLAKFAFNASSASAGAVLDKFGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RS14_SALHS
Sequence: MAKQSMKAREVKRVALADKYFAKRAELKAIISDVNATDEDRWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHAFLRKFGLSRIKVREAAMRGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: TOLB_YERPB
Sequence: MKQAFRVALGFLVLWASVLHAEVRIEITQGVDSARPIGVVPFKWMGPGTPPEEIGAIVGADLRNSGKFNPIDAARMPQQPSTAAEVTPAAWTALGIDAVVVGQVQPSADGSYVVSYQLVDTSGSAGSILAQNQYKVTKQWLRYSAHTVSDEVFEKLTGIKGAFRTRIAYVVKTNGGKFPHELRVSDYDGYNQFVVHRSPEPLMSPAWSPDGSKIAYVTFESGKSALVIQTLANGAIRQVASFPRHNGAPAFSPDGTKLAFALSKSGSLNLYVMDLASGQISQVTDGRSNNTEPSWFPDSQNLAYTSDQGGRPQVYKVNINGGVPQRITWEGSQNQNADVSPDGKFLVLVSSNGGAQHIAKQDLETGAVQVLTDTLLDETPSIAPNGTMVIYSSTQGLGSVLQLVSTDGRFKARLPATDGQVKFPAWSPYL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: FXDC2_MACFA
Sequence: MKGEAGHMLHNEKSKQEGYIWGSMRRTAFILGSGLLSFVAFWNSVTWHLQRFWGASGYFWQAQWERLLTTFEGKEWILFFIGAIQVPCLFFWSFNGLLLVVDTTGKPNFISRYRIQVGKNEPVDPVKLRQSIRTVLFNQCMVSFPMVVFLYPFLKWWGDPCRRELPTFHWFLLELAIFTLIEEVLFYYSHRLLHHPTFYKKIHKKHHEWTAPIGVISLYAHPIEHVVSNMLPAIVGPLVMGSHLSSITMWFSLALIITTISHCGYHLPFLPSPEFHDYHHLKFNQCYGVLGVLDHLHGTDTMFKQTKAYEKHVLLLGFTPLSESIPDSPKRMQ
What is the function of this protein?
Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression.
What are the official names of this protein?
Fatty acid hydroxylase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Multi-pass membrane protein.
Protein: RUTF_ECO1A
Sequence: MNIVDQQTFRDAMSCMGAAVNIITTDGPAGRAGFTASAVCSVTDTPPTLLVCLNRGASVWPVFNENRTLCVNTLSAGQEPLSNLFGGKTPMEHRFAAARWQTGVTGCPQLEEALVSFDCRISQVVSVGTHDILFCAIEAIHRHATPYGLVWFDRSYHALMRPAC
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF, FMN reductase, NADH-flavin reductase RutF, NADH:flavin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: SUCC_BACHK
Sequence: MNIHEYQGKAVLRSYGVSVPNGKVAFTVEEAVEAAKELGTDVCVVKAQIHAGGRGKAGGVKVAKNLDEVRTYAESILGTTLVTHQTGPEGKEVKRLLIEEGCDIKKEYYVGLVLDRATSQVVLMASEEGGTEIEEVAEKTPEKIFKEYIDPAVGLQGFQARRIAFNINIPKELVGQAVKFMMGLYRAFIEKDCSIAEINPLVTTGDGKVMALDAKLNFDSNALYRHKDILELRDLDEEDAKEIEASKYDLNYIPLDGNIGCMVNGAGLAMATMDIIKHYHGDPANFLDVGGGATAEKVTEAFKIILSDKNVKGIFVNIFGGIMKCDVIAEGVIEATKQVGLELPLVVRLEGTNVELGKKILNESGLNIVAAESMADGAQKIVSLVG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RL3_TERTT
Sequence: MTIGIVGRKSGMTRIFTDDGLSVPVTVIEVDPNRITQVKSVETDGYAAVQVTVGSRRASRVTKAEAGHFAKAQTEAGRGVWELRNEAGEAFEVGGQLTVEAFEAGQKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRAPGSIGQCQTPGRVMKGKKMSGHMGAERVTTQNLEVVRVDVERNLLLIKGAVPGAPGGDVFIRPAVKLRNNG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: TPIS_LACDL
Sequence: MSRTPIIAGNWKLNMNPKETVEFVNAVKDQLPDPSKVESVICAPAVDLDALLKAAEGSNLHVGAENCYWENSGAFTGETSPAVLKEMGVQYVIIGHSERRDYFHETDEDINKKAKAIFANGLTPILCCGESLEIREAGKEKEWVVSQIKADLEGLTSEQVSKLVIAYEPIWAIGTGKTASSDQAEEMCKTIRETVKDLYNEETAENVRIQYGGSVKPANIKELMAKPNIDGGLVGGASLVPDSYLALVNYQD
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y6513_BACAN
Sequence: MATMKIKEWFFQSKKALVIGILAVITLFVSFTFTPIAYAFDWYEFLGLKDVDTEKVVAFLQNEWIQYADFLGSIWQSIQGGIIKTLLYIVSALEGLIPDTFSFFDILKDAGLNDFASSIIKGLFYALFVLVIVWLGIRTIIQHKPPRFKSVGVNILVMIGLLGGLNELMADMQKMSTDFFSETTNTSKAKDGLAWDLVKQNTADLIYLSKTGFEPIQSKKENEPAISSTDSKPKNGMSKDIFLKAQLGDVVTPKVIEMLTSQKDIPKETEYLVYKITNDGDKETVEKINDSVFNPFKDKFPGGYVRYPMNFGTIFWGLLALGVAYLFTVFVFVMTIFEIAMKKIIAPIVFVTDIETGEKTKMVIQDIFKGFLVFAFTGLNLRVYTIIVNYLAEKDINAFLYIVAMVCLTVALINGSESILKYFGVDVGLKEGKNHLTGMVGGAMAAKGAIKGAGRMFSGAKNLMSGGSGQTREDTPKRSEMDSNHESAESQGEQKNTAKGGGMQAKKFARNTGAAMSYAANRGVGGMMNDAGNKVAETVGGAVDKGKEKVSGVAKGVSDSVKGTVSEFKGGQAEGKQKAQENADRQTLNTIGKGIQNNANAGIEPSASPKIANRPNVASISNERQQGNIKGERQTAEREIELQNKLRNTGKEEGKQGNVKSERQTAEREIELQNKLRNTGSTEGQQGNVKGERQTAEREIEIQNKLRNTGGTEASQGNMKSGSQTVQREVNVLDTLRSTGGTGTINSDAKAGVATIQRDVNVQNNIRGSEAVDSNVRAGSTTVQRDVNVQNNVRGSEAVESNVRAGSTTVQRDVNVQNNVRGSEAVESAVRAGSTTVQRDVNVQNNVRGSEAVESSVRAGSTTVQRDVNVQNNVRGSEAVNHTVRAGATTVQRDVNVQNNVRGSSEVTADVRVGTTTVQRDVNVQDNVKEVRKSRLRPRGSTQNRTDQLRRR
What are the official names of this protein?
Uncharacterized protein pXO2-14/BXB0013/GBAA_pXO2_0013.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SUCC_SALEP
Sequence: MNLHEYQAKQLFARYGLPAPVGYACTTPREAEEAASKIGAGPWVVKCQVHAGGRGKAGGVKVVKSKEEIRAFAENWLGKRLVTYQTDANGQPVNQILVEAATDIGKELYLGAVVDRSSRRVVFMASTEGGVEIEKVAEETPHLIHKVALDPLTGPMPYQGRELAFKLGLEGKLVQQFTKIFMGLATIFLERDLALIEINPLVITKQGDLICLDGKLGADGNALFRQPDLREMRDQSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGEPANFLDVGGGATKERVTEAFKIILSDDNVKAVLVNIFGGIVRCDLIADGIIGAVEEVGVNVPVVVRLEGNNAELGAKKLADSGLNIIAAKSLTDAAQQVVAAVEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: ACLY_CAEEL
Sequence: MSAKAVSELSGKEVLYKYFEPSGLLSAPHAFHVKAGENFDEIANKYEWLARDNKGVIKPDQLIKRRGKLGLVKIGTPQELKAWFEKTGDSYVRVGQTEGRLHTFIVEPFCAHTEKDEMYIAIYSERFRDVIMFYEQGGVDIGDVEEKARTVSVPVQLNENAMTPSDEELTTLLGPLKDSDIVRRFVVELYKAYKDLHFTYLEINPFVLLNNQIHVLDLAARLDETANFLCADKWKSRLTPYGGPNHVEFPAPFGRDLTSEEQYISEMDAKTGASLKLTILNRKGRVWTMVAGGGASVVFTDTVCDLGGASELANYGEYSGDPSESQTYEYAKTLLSVMTEGTPRPDGKVLIIGGSIANFTNVAKTFGGIVRAFETFVSKLKEHKVTIFVRRGGPNYQEGLRRIKDAATKLELPIHVFGPETHMTAIVGAALGVKPMPTVPTAPQTTGQFLLSPERNTGGTERAPPSPAANATPTEHPLTTAQQNKLKSFRGLFEDDTKAIIWGQQAKAIQGMLDFDYVCRRSSPSVVASTYPFTGDNKQKYYFGQKEILIPAYKSMAKAFATHPDASIMVTFASMRSVFETVLEALEFPQIKVIAIIAEGVPENQTRKLLKIAHDRGVTLVGPATVGGIKPGCFKIGNTGGMMDNILASKLYRPGSVAYVSRSGGMSNELNNIISQNTNGVYEGIAIGGDRYPGSTYTDHVIRYQNDDRVKMIVLLGEVGGVEEYKIVDLLKQKKVTKPLVAWCIGTCADHITSEVQFGHAGASANALGETAACKNAALRASGALVPESFDDLGNKIRQTYDELVSQQIIVPQPEVPPPAVPMDYAWARELGLIRKPASFMTSICDERGEELNYAGVPITKVLESDMGIGGVLGLLWFQKRLPPHANKFIEICLMLTADHGPAVSGAHNTIVCARAGKDLISSLTSGLLTIGDRFGGALDGAARQFSEAFDQGWSANQFVSEMRKKGKHIMGIGHRVKSINNPDKRVEILKRFAMDKKEFAQETPLFEYALEVEKITTAKKPNLILNVDGAIAILFVDILRHSGMFTKQEAEETIEIGSLNGLFVLGRSIGFIGHYLDQSRLKQGLYRHPWDDISYIMPESNLVKF
What is the function of this protein?
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
What are the official names of this protein?
Probable ATP-citrate synthase, ATP-citrate (pro-S-)-lyase, Citrate cleavage enzyme.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_PSEFS
Sequence: MSQPTPAVRTFQDLILALQQYWAEQGCVVLQPYDMEVGAGTFHTATFLRAIGPETWNAAYVQPSRRPTDGRYGENPNRLQHYYQFQVVLKPNPDNFQELYLGSLKHVGLDPLVHDIRFVEDNWESPTLGAWGLGWEVWLNGMEVTQFTYFQQAGGIECYPVTGEITYGLERLAMYLQGVDSVYDLVWADGPFGKVTYGDVFHQNEVEQSTYNFEHANVDKLFELFDFYESEAKRLIELDQPLPLPSYEMVLKASHTFNLLDARRAISVTARQQYILRVRTLARSVAQAYLLARAKLGFPMATPDLRDEVLAKLEAAQ
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORC2_DROME
Sequence: MSASNKGGYKTPRKENLMSIENLTNSEEESEDLNTAMVGNAVESQPKVTSRRSTRRPSPTKKYQAYQKESNGKGQEERIVVNYVEMSDERSSDAEDQEEEESIEESENAARPAAKDLHLIQSEYNVAGTSMFGFNTPKKRDAMALAALNATPCTPKTPKTPRLGVKTPDTKRKKSMDQPKTPAHVRTRVKKQIAKIVADSDEDFSGDESDFRPSDEESSSSSSSSDAGNSSDNDAADDEPKTPSRARRAIVVPVLPKTPSAARLRQSARAKKSNEFVPESDGYFHSHASSKILTSDHTLDRLKNPRLAADRVFSLLSEIKTSAEHEGSINAIMEEYRSYFPKWMCILNEGFNILLYGLGSKHQLLQSFHREVLHKQTVLVVNGFFPSLTIKDMLDSITSDILDAGISPANPHEAVDMIEEEFALIPETHLFLIVHNLDGAMLRNVKAQAILSRLARIPNIHLLASIDHINTPLLWDQGKLCSFNFSWWDCTTMLPYTNETAFENSLLVQNSGELALSSMRSVFSSLTTNSRGIYMLIVKYQLKNKGNATYQGMPFRDLYSSCREAFLVSSDLALRAQLTEFLDHKLVKSKRSVDGSEQLTIPIDGALLQQFLEEQEKK
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication (PubMed:11137005).  DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far (PubMed:11137005).  ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (PubMed:11137005).  As part of the ORC complex, might also have a role in mRNA export (Probable).
What are the official names of this protein?
Origin recognition complex subunit 2, DmORC2.
What is the protein family that this protein belongs to?
Belongs to the ORC2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Note=Centromeres of metaphase and anaphase chromosomes of early syncytial embryos. Later in development, found in pericentric regions of late anaphase and telophase chromosomes.
Protein: CASB_TRIVU
Sequence: MKLLILTCLVVLAVARPMVEKISESEEHVTDVPENEHRLEINRYLRPEYEMMNLYYQPFYWSEEMRNLKMTSLPKDRRMAVLKSVVSDDMLPPLQHKSLSLPKPKVLPLSHRQILPPHTLRMVPLSHKLFTIPKREMLPISERERLPAHERENLLAHEREILLAPQREMSLIPEREILLAAERVVLPEQEREIRPDNEREVLAVHKREILPASEKEKVLPLFQERVLPLHRREIVPPYQRDTIARREILPVDQRELMPEVVAVDLYPFFQPVANFYYPAELNEKN
What is the function of this protein?
Important role in determination of the surface properties of the casein micelles.
What are the official names of this protein?
Beta-casein.
What is the protein family that this protein belongs to?
Belongs to the beta-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL29_GRABC
Sequence: MTKPADIRVKSADELGALLIDLRKEQFNLRFQQATGQLEKTGRAVQVRRDIARVKTILAERQRAAAPKA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: RS4_ECOLI
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
Part of the processive rRNA transcription and antitermination complex (rrnTAC).  The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP).  It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis.  This subunit may play a particular role in long-distance rRNA annealing needed for pre-rRNA processing.
What are the official names of this protein?
30S ribosomal protein S4, Small ribosomal subunit protein uS4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SAP25_MOUSE
Sequence: MSPLPLRDPSHQANAGPRLVEPSCGPGVSLSNRTLCHPSWPMYDNWGRSPTTSERPEEEQVVSKDTGVPVRNYEDVFLLDPLLPCGQRVPLILTKPPQQAMDSRKLLLPPPIMSPSVHPSSSQACSSTWLSEAEMIALAGLLQMSQGEQTPNCVASSLPSTSCPDPVSVSEDPGPSGDQSCSGTDT
What is the function of this protein?
Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.
What are the official names of this protein?
Histone deacetylase complex subunit SAP25, 25 kDa Sin3-associated polypeptide, Sin3 corepressor complex subunit SAP25, mSin3A-binding protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: Y530_STAAC
Sequence: MDSHFVYIVKCSDGSLYTGYAKDVNARVEKHNRGQGAKYTKVRRPVHLVYQEMYETKSEALKREYEIKTYTRQKKLRLIKER
What are the official names of this protein?
UPF0213 protein SACOL0530.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: RK20_ARAHI
Sequence: MTRIKRGYIARRRRTKLRLFASSFRGAHSRLTRTMTQQRIRALVSAHRDRGKRKRDFRRLWITRLNAVIHETGVFHSYNRFIHNLYKKQLLLNRKILAQIALLNRSCLYTISNEIKE
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EPMA_HAES1
Sequence: MSLNEQWQPSASIQNLLARAKIIADIRRFFTERGLLEVETPVLSEFGVTDVHLSTFSTAFTSPFMEKSKTLWLTTSPEYHMKRLLAAGSGAIFQLCKVFRNEESGKKHNPEFTMLEWYRPHFDMHRLINEVDDLLQQTLDCEPAEMASYQFVFQEHVGIDPLSAPINELIEKARECHLDGAENEDRDTLLQFLFSTLVEPNIGQNKPIAVYHFPATQAALAQISSEDHRVAERFEFYYKGIELANGFNELTDAQEQEHRFNQDNRLREQLGLPQHEIDHRFLGALQAGLPNTAGVALGVDRLIMLALGAENISEVISFNIDCA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P).  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: TRPT1_HUMAN
Sequence: MNFSGGGRQEAAGSRGRRAPRPREQDRDVQLSKALSYALRHGALKLGLPMGADGFVPLGTLLQLPQFRGFSAEDVQRVVDTNRKQRFALQLGDPSTGLLIRANQGHSLQVPKLELMPLETPQALPPMLVHGTFWKHWPSILLKGLSCQGRTHIHLAPGLPGDPGIISGMRSHCEIAVFIDGPLALADGIPFFRSANGVILTPGNTDGFLLPKYFKEALQLRPTRKPLSLAGDEETECQSSPKHSSRERRRIQQ
What is the function of this protein?
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
What are the official names of this protein?
tRNA 2'-phosphotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: ACCA_PELPB
Sequence: MATKVVLDFEKPLFELEAKLDEMRQCLRNSTREQSPSETEMLNHDIETLELKVDALRRSIYKNLTRWQKVQLARHPARPYTLDYIHLMTRDFLELAGDRRYSDDKAIIGGFARIEESATGFSQPVMIIGHQKGRDTKSNLYRNFGMAQPEGYRKALRLMQLAEKFRKPVITLIDTPGAFPGIEAEERGTAEAIARNLYEMAKLTVPVICVIIGEGASGGAIGIGVGDRILMAENSWYSVISPESCSSILWRSWKYKEQAAEALQLTAVDLLSQGIIDRIIPEPVGGAHTDPDVMAATLKEILIEELKALLPKDPATLVHERIEKFSSMGVWNEEE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.