PharMolix/UniProtQA huggingface dataset:
Protein: RUVA_ECOL5
Sequence: MIGRLRGIIIEKQPPLVLIEVGGVGYEVHMPMTCFYELPEAGQEAIVFTHFVVREDAQLLYGFNNKQERTLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLIVEMKDRFKGLHGDLFTPAADLVLTSPASPATDDAEQEAVAALVALGYKPQEASRMVSKIARPDASSETLIREALRAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: BPT_AERHH
Sequence: MTEEVILKVGLTPKHQCSYLGHEQEQLLVLMDHSLLNASGYERLLTAGFRRSGNDIYRPHCPACNACQSLRIHSERFVPSRSQKRIRQLNQDIELVLSYDDKPEYYQLYERYIRERHHDGSMYPPSRTQYKGFLHCDWMPPLYLEMRKDNRLIGVATTDLLPHSLSAMYTFFDPAHADRSLGTFAILSQLELARRTGRSWLYLGYLVEECRKMNYKRQYLPHERLIQGEWKNIDSKPE
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLMA_HAEIE
Sequence: MVEEQLSLSGVEEIAPKIETPKIEKRTVKERRQQVLTVLIHMLHSERGMERMTTARLAKEVGVSEAALYRYFPSKTKMFEALIEHIESTLLSRITASMRNETQTMNRIHDILQTILDFARKNPGLTRVLTGHALMFEEAQLQARVAQFFDRLEMQFVNILQMRKLREGRAFNVDERIIASHLVTLCEGQFMRYVRTNFRLNSSQSFEQQWRFIEPLFA
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: Y2401_ARCFU
Sequence: MRLNKLISGLGLAFAIYFFLLNQERLFGEVFVVADEMQRAALLTLIVAYSALASVERLNPFRLVLVPFILIVSSDITFNSLLSHGYPQYFVVYQSVRGYIAIFSGSFAFSYIRFTDKPLYQSLISATSLGIAGLSSYYLFSYLSEVFGLPSLALPSLALFLILAVTALSTAFEGEVFQWIRSERTFLMLVLFILTFYTLAIKPQLSERPGIADFIEWSIVALTFIKISRDFRRSVEVDEREFIASHVPKERVFRDRLYSELEFGEKAFVEGGSKVPLTIALVRALSNVEAPKLAAILAPLISYEDEKLPALSFPWERRIIESRNRRRREKVVERIRAEVMREVKDFNR
What are the official names of this protein?
Uncharacterized protein AF_2401.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DHSC_ECO57
Sequence: MIRNVKKQRPVNLDLQTIRFPITAIASILHRVSGVITFVAVGILLWLLGTSLSSPEGFEQASAIMGSFFVKFIMWGILTALAYHVVVGIRHMMMDFGYLEETFEAGKRSAKISFVITVVLSLLAGVLVW
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase cytochrome b556 subunit, Cytochrome b-556.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b560 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LYRA_STAAN
Sequence: MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILVFKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPITHILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYNFLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAIVAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKTGVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESAESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
What are the official names of this protein?
Lysostaphin resistance protein A.
What is the protein family that this protein belongs to?
Belongs to the LyrA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL23_BURPS
Sequence: MSEIRKNDHRLMQVLLAPVISEKATLVADKNEQVVFEVAPDATKQEVKAAVELLFKVEVDSVNVLVQKGKQKRFGRSMGRRKDVKKAYVCLKPGQEINFEAEAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RNZ_STRP6
Sequence: MELQFLGTGAGQPAKQRNVSSLALKLLDEINEVWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHIFGLPGFLSSRSFQASEEQTDLDIYGPIGIKTYVLTSLKVSGARVPYQIHFHEFDDKSLGKIMETDKFVVYAERLAHTIFCMGYRVVQKDLEGTLDAEALKAAGVPFGPLFGKIKNGQDVELEDGRLICAKDYISAPKKGKIITIIGDTRKTSASVKLAKDADVLVHESTYGKGDERIARNHGHSTNMQAAQIAHEAGAKRLLLNHVSARFLGRDCRQMEKDAATIFENVKMVQDLEEVII
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: YZ23_AQUAE
Sequence: MNSKELTKEVLNLFQTLPEFYFEHFHEYGIWFPIVVGIIASAVGMFGMLLFYAAEPDTEFEKLPFFVRKIASREGDEDTYFALGIYPIIILPAEGKIIKAAAIHEFFHVLFKFPWVIFQPVTGIFMTQLPYRFFNMLTQFLYTVLPKHIVLMLILLSMPILKKFGMEKSQVYELLSLASKYITFVYICALAAVIEELLVNIATAIYFLITFKFNENTFLVTVGSSLTYLSNIPMIFACMWMDFHYADGQGVEMAKKFIELVFKTELSSLFF
What are the official names of this protein?
Uncharacterized protein aq_aa23.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RSPRY_PONAB
Sequence: MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGATTTMGNSCICRDDSGTDDSVDTQQQQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQEPPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
What are the official names of this protein?
RING finger and SPRY domain-containing protein 1.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAT_SALPK
Sequence: MSSRILTSDVIGIDVLLHDHHAVLAKSTGGAVAVFANNAPAFYAVTPARMAELLALEEKLSRPGSDVALDAQFYEEPEAAPVAIPCGKFAMYPAWQPDADFQRQAALWGVALREPVTAEELAAFIAYWQAEGKVFHHIQWQQKLARSVQISRSSNGGMPQRDINSVSEPDNHIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: PAFA_MYCTF
Sequence: MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDSLVQLVTHDRAGEWVLEDLLVDAEQRLADEGIGGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMSETTTMLKVGTAALVLEMIESGVAFRDFSLDNPIRAIREVSHDVTGRRPVRLAGGRQASALDIQREYYTRAVEHLQTREPNAQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDRYDMELSHPKIAQLDLAYHDIKRGRGIFDLLQRKGLAARVTTDEEIAEAVDQPPQTTRARLRGEFISAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVKRLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: RS11_PSEF5
Sequence: MAKPAARPRKKIKKTVVDGIAHIHASFNNTIVTITDRQGNALSWATSGGSGFRGSRKSTPFAAQVAAERAGQAALEYGLKNLDVNVKGPGPGRESAVRALNGCGYKIASITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: TATA_CHLL2
Sequence: MFGLGGQELILILLIILLLFGAKKLPELARGLGKGMKEFKKAQTEIEDEFNKVVDEPPRKTPENSTGSKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AROF_THEMA
Sequence: MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVESVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSELGVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADIIQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIRTFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVHPEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN
What is the function of this protein?
Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
What are the official names of this protein?
Phospho-2-dehydro-3-deoxyheptonate aldolase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, DAHP synthase, Phospho-2-keto-3-deoxyheptonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class-I DAHP synthase family.
Protein: GLMS_CHLMU
Sequence: MCGIFGYLGQRNAVPLVLEGLSKLEYRGYDSAGIAALTKDHLFVEKSVGPVSQLCSKVSSDMHSQVAIGHTRWATHGEPSRFNAHPHVDMYESCALVHNGIIENFQTLREDLSSKGVEFSSDTDTEVIVQLFASRYRETGDLVQSFSWTLKQLQGSFACALVHQDHPEILLCATYESPLILGLGEEEVFISSDVHAFLKYSCQIQTLASGELAVLRIGRPVEIYNFELSRIQKEVRCIDHAEGSLDKQGFDYYMLKEIYEQPEVFERILHFVCEENGFAESFLKEFSFEGIESLHIVACGSSYHAGCLAKYVIESMVSIPVYVETASEFRYRQPYIAKRSLAILISQSGETADTLAALNEFRKLDEVRVLGICNVRGSVLASRVDHCVFIEAGLEVGVASTKAFTAQLLVLILLGLKLASQRQEISKQDLMQAVQGLRELPRLTRLFLDSSIHDWRCRQSKETSFIFLGRRFMYPICMEAALKLKEIAYVEANAYPAGEMKHGPIALIQEGTPVIVYCGDPFVYTKTIGAIMEVKARKAYVIALARESNQDIAAVSDEQIYIPDSHDLAAPILFAIAGQIMAYTMALQKGTEVDRPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPA_ASHGO
Sequence: MEQSMSSEQAERVAGRVEQLGGFQNNESINQRALLLLQRNRQRRQLLQRQEDRTRYIPDDAKRRVVERVAEPAAAESRADGAREEERAARPARPRETRRIAKKPQRYRPSDVALQEIRRYQRSTELLISRMPFARLVKEVTDQFTTVDQQMRWQSMAILALQEASEAYIVGLLEHTNLLALHAKRVTVMRKDMQLARRIRGQFI
What is the function of this protein?
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes.  Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore.  Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
What are the official names of this protein?
Histone H3-like centromeric protein CSE4, CENP-A homolog, CENPA homolog.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.
Protein: DGTP_PSEAE
Sequence: MPGAVDFKERISRQRPHDRETYGHAGNTDLQDIVYQLESDRGRIVNSAAVRRLQQKTQVFPLERNAAVRSRLTHSLEVQQTGRFIVRTLFRQLGPRAAEVGLDGLEGALESLVEMACLMHDVGNPPFGHFGEYAINDWFERNLDALFERRIPPGQGDGLLQQRMLTDLKHFEGNAQAIRLVVKLLRLNLTYTQTAGLLKYVRPAYEPKPDKAAANHYLNKKPGFYLSEEAFVDELRRVLGMRPGTRHPVAYIMEAADDISYCLADIEDSVEKGILDIRQLADLLVKKFAVHHSPDAPIPGDADNMSFQRMVDYSLEKAEREPINKVSEFFIRLRVKMIHPLVQHAAQQFIDNFEAVHAGTLGRALMEDGSLPHAIVQTFKDVAMEWVFCHPEVETLELQGYRIIQGLLDFYAPLLRLPAEEFQALAEGRQAAAPHPQLLVRRLPSQQIKAYLEAMKGVAEDPLQRQWEFYHRCRMLQDFVSGMTDQHAQDEYRALSAL
What is the function of this protein?
dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.
What are the official names of this protein?
Probable deoxyguanosinetriphosphate triphosphohydrolase, dGTP triphosphohydrolase, dGTPase.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 1 subfamily.
Protein: ERF3_YEAST
Sequence: MSDSNQGNNQQNYQQYSQNGNQQQGNNRYQGYQAYNAQAQPAGGYYQNYQGYSGYQQGGYQQYNPDAGYQQQYNPQGGYQQYNPQGGYQQQFNPQGGRGNYKNFNYNNNLQGYQAGFQPQSQGMSLNDFQKQQKQAAPKPKKTLKLVSSSGIKLANATKKVGTKPAESDKKEEEKSAETKEPTKEPTKVEEPVKKEEKPVQTEEKTEEKSELPKVEDLKISESTHNTNNANVTSADALIKEQEEEVDDEVVNDMFGGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMDTNKEERNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGASQADVGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERYDQCVSNVSNFLRAIGYNIKTDVVFMPVSGYSGANLKDHVDPKECPWYTGPTLLEYLDTMNHVDRHINAPFMLPIAAKMKDLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQNIYNETENEVDMAMCGEQVKLRIKGVEEEDISPGFVLTSPKNPIKSVTKFVAQIAIVELKSIIAAGFSCVMHVHTAIEEVHIVKLLHKLEKGTNRKSKKPPAFAKKGMKVIAVLETEAPVCVETYQDYPQLGRFTLRDQGTTIAIGKIVKIAE
What is the function of this protein?
Involved in translation termination.  Stimulates the activity of ERF1.  Binds guanine nucleotides.  Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs.  Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.
What are the official names of this protein?
Eukaryotic peptide chain release factor GTP-binding subunit, ERF-3, ERF3, ERF2, G1 to S phase transition protein 1, Omnipotent suppressor protein 2, PSI no more protein 2, Polypeptide release factor 3, Translation release factor 3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STHD_PHANO
Sequence: MAAYFLLGLYGSTLVYRLIFHPLNRFPGPLAARISDLWLCTQLGGHDMHHLSERLSKRYGEFVRIGSSTLMLTHPKAVAAIYGPGSPCRKGTFYDLEQPNRGIATRDESLHAGRRRVWSRGFGDKALRTYEPRVAAYVHMLLGRLADARGKPVDMARLAEAFAFDTMGDLGLGADFGMLRQARTHEAVEQLVQGMTIMGRRLPMWLMRLLIDVAQALVPTAATTGFLGFCHHHLDRFMADPRRSERPSLMAPLLSHYEKQNIADRDLSILRNDCRFIIIAGSDTVAATLTFAFFYLAKHPGHVTRLREELFPLRAADGTFSHQRIFDAPHLNAVINETLRLHPPASTIPRVTPPQGLVVADTFIPGDMTVFSSQYALGRSEAIYSKASDFIPERWCSRPDLIKDGSAYAPFSIGHHSCLGRPLALMEMRLVLAETLSRFDIAFAPGFDANHFLQHVHDCMSWHIGKLGLTFTAIE
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the phytotoxin stemphyloxin II (PubMed:31553484).  The first step of the pathway is the synthesis of dehydroprobetaenone I by the polyketide synthase sthA and the enoyl reductase sthE via condensation of one acetyl-CoA starter unit with 7 malonyl-CoA units and 5 methylations (PubMed:31553484).  The C-terminal reductase (R) domain of sthA catalyzes the reductive release of the polyketide chain (PubMed:31553484).  Because sthA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase sthE (PubMed:31553484).  The short-chain dehydrogenase/reductase sthC then catalyzes reduction of dehydroprobetaenone I to probetaenone I (PubMed:31553484).  The cytochrome P450 monooxygenase sthF catalyzes successive epoxidation, oxidation (resulting from epoxide opening) and hydroxylation to install a tertiary alcohol in the decaline ring to yield betaenone C from dehydroprobetaenone I and betaenone B from probetaenone I (PubMed:31553484).  The FAD-linked oxidoreductase sthB is responsible for the conversion of betaenone C to betaenone A via an intramolecular aldol reaction between C-1 and C-17 to form the bridged tricyclic system in betaenone A (PubMed:31553484).  Finally, the cytochrome P450 monooxygenase sthD catalyzes the hydroxylation of C-15 to afford the final metabolite stemphyloxin II (PubMed:31553484).
What are the official names of this protein?
Cytochrome P450 monooxygenase sthD, Stemphyloxin II biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: UL128_HCMVM
Sequence: MSPKNLTPFLTALWLLLDHSRVPRVRAEECCEFINVNHPPERCYDFKMCNRFTVALRCPDGEVCYSPEKTAEIRGIVTTMTHSLTRQVVHNKLTSCNYNPLYLEADGRIRCGKVNDKAQYLLGAAGSVPYRWINLEYDKITRIVGLNQYLESVKKHKRLDVCRAKMGYMLQ
What is the function of this protein?
Plays a role in viral entry into host cells.  Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131.  This complex is required for entry in epithelial, endothelial and myeloid host cells (PubMed:23853586, PubMed:17942555).  Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection (PubMed:30057110).  Additionally, monomeric UL128 may interfere with certain inflammatory cytokines to increase infection and dissemination by blocking monocytes migration (PubMed:21367908).
What are the official names of this protein?
Envelope protein UL128.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL128 protein family.
What are the subcellular locations of this protein?
Virion membrane. Note=Found as a pentameric complex at the surface of virion envelope.
Protein: MIAB_BIFLD
Sequence: MNEDMMTEAERASIAADGTDGLLGKRGKGVFHIHTLGCQMNVHDSERIAGVLEANGYVPATEDQINDNDLDLLVLNTCAVRENAAERMYGTIGRFNRVKLVRPNLQIAVGGCMAQLDRKKIADTAPWVSAVFGTKNIEDLPKLLDQNRATGKAQVQVTEQLRQFPSQLPAARASRISSWVAISVGCNNTCTFCIVPTTRGKEKDRRPGDILDEIRQCVADGAKEVTLLGQNVNSFGYGIGDRYAFSKLLRACGTIDGLERVRFTSPHPAAFTDDVIAAMAETPNIMHQLHFPLQSGSDRILRAMRRSYRSAKFLDILGRIRAAMPDAQISTDIIVGFPGETEEDFQQTMDVVRQARFSSAFTFIYSPRPGTPAAAMEQIPRDVVQDRFDRLVALQEQITEENLATFEGRDVEVMITGKLGKKDTDTHRVTGREKTGVLVHIGVPEGEPVPEIGDFVTATVTHAGRHNLLADPDVAAGQTYSVRH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRDD_SALPC
Sequence: MINPNPKRSDEPVFWGLFGAGGMWGAIIAPVIVLLVGIMLPLGLFPGDALSFERVLTFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTAIGVITL
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LDH1_STAA1
Sequence: MNKFKGNKVVLIGNGAVGSSYAFSLVNQSIVDELVIIDLDTEKVRGDVMDLKHATPYSPTTVRVKAGEYSDCHDADLVVICAGAAQKPGETRLDLVSKNLKIFKSIVGEVMASKFDGIFLVATNPVDILAYATWKFSGLPKERVIGSGTILDSARFRLLLSEAFDVAPRSVDAQIIGEHGDTELPVWSHANIAGQPLKTLLEQRPEGKAQIEQIFVQTRDAAYDIIQAKGATYYGVAMGLARITEAIFRNEDAVLTVSALLEGEYDEEDVYIGVPAVINRNGIRNVVEIPLNDEEQSKFAHSAKTLKDIMAEAEELK
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate (Potential).  Appears to be the primary factor that allows S. aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells (By similarity).
What are the official names of this protein?
L-lactate dehydrogenase 1, L-LDH 1.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPB2_ARATH
Sequence: MSSTSQKRKKIQKKFKNRGYNLKFDALDEILVFADQFPDDDDGEAIDLLLDNLQETHKSSTVDAESVRGLINRLLGAHNAPEEPTTSASSLAIIDAFLVPKFGYDSVKKKFNEHTSSLPIHGEASAKTALYRERFMLLSQRVSRAEHFSRPAFDAEMSQFENNEISSIQSLISQRGRKWVMGVISQLEDGHFYLEDLSASVEIDLSKAKITTGFFTENTIILAEGEMQVNGIFQVITCGFPPLEDRDKTLKAHSEYDFFGGGTLTKEEMIKLADLERQAVNDTFVILSDIWLDDEEVMRKLETVLDGFESVETVPSLFVFMGNFCSRPCNLSFGSYSSLREQFGKLGRMIGNHPRLKENSRFLFIPGPEDAGPSTVLPRCALPKYLTEELRNIIPNAIFSSNPCRVKFYNQEIVFFRQDLLYRMRRSCLVTPSSEETNDPFKHLVYTITHQSHLCPLPLMVQPIIWNYDHALRLYPTPHTIVLGDKSEQEVCKFGGTTCFNPGSFSTDSTFVAYRPSTQEVELSAL
What is the function of this protein?
As accessory component of DNA polymerase II participates in chromosomal DNA replication.  Required for the timing and determination of cell fate during plant embryogenesis and root pole development, by promoting cell cycle and cell type patterning.  Necessary for proper shoot (SAM) and root apical meristem (RAM) functions (By similarity).  Is essential to promote the first divisions of the zygote (PubMed:16212602).
What are the official names of this protein?
DNA polymerase epsilon subunit B, DNA polymerase II subunit 2, AtDPB2, Protein CYCLOPS 2.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase epsilon subunit B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IER5L_DANRE
Sequence: MECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYMNEKYAEIYRMQQYEEVMTVCNEIQELNPLDLAEDCEDQTADCCGSASESASLCGALLPAVGHQTSPAAQHIQPASACSVPLALQSEEVCKAAPEPSFYRSCCAEAYPVSNCDFSPVNNMHCNKTTVLDLDTHVVTTVENGYLHQDCCASLQQCCQGAQSPAKKRKLDFGYYVSEIEEAPDFTPCKRAKFEDSSYAITEPLDTSNISNLISIFGSGFSGLVSRQADLEQALNGQFCSKQALASLGAWTRAIVAF
What are the official names of this protein?
Immediate early response gene 5-like protein.
What is the protein family that this protein belongs to?
Belongs to the IER family.