PharMolix/UniProtQA huggingface dataset:
Protein: LPXA_THIDA
Sequence: MATIHPTALVAPGARLADDVEIGPYSVIGEHVEIGAGTTVGAHAVLTGHTTIGERNKIFHFVSLGEAPQDKKYAGEPTRLEIGDYNVIREFCTFNIGTVQDRGVTRIGHHNWIMAYVHIAHDCVVGDRTIFANNASLAGHAEVGDWAILGGFTGVHQFCKVGAHVMTGISSVVFKDIPPFVMASGQPAAPHGLNNEGLKRRGFSAEALSALKRAYKILYREGNTLAEAQAKLAPEAAKHAEVQQLLDFLARAERGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLA1_CAMJE
Sequence: MGFRINTNVAALNAKANADLNSKSLDASLSRLSSGLRINSAADDASGMAIADSLRSQANTLGQAISNGNDALGILQTADKAMDEQLKILDTIKTKATQAAQDGQSLKTRTMLQADINRLMEELDNIANTTSFNGKQLLSGNFINQEFQIGASSNQTVKATIGATQSSKIGLTRFETGGRISTSGEVQFTLKNYNGIDDFQFQKVVISTSVGTGLGALADEINKNADKTGVRATFTVETRGIAAVRAGATSDTFAINGVKIGKVDYKDGDANGALVAAINSVKDTTGVEASIDANGQLLLTSREGRGIKIDGNIGGGAFINADMKENYGRLSLVKNDGKDILISGSNLSSAGFGATQFISQASVSLRESKGQIDANIADAMGFGSANKGVVLGGYSSVSAYMSSAGSGFSSGSGYSVGSGKNYSTGFANAIAISAASQLSTVYNVSAGSGFSSGSTLSQFATMKTTAFGVKDETAGVTTLKGAMAVMDIAETAITNLDQIRADIGSVQNQVTSTINNITVTQVNVKAAESQIRDVDFAAESANYSKANILAQSGSYAMAQANSVQQNVLRLLQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.  FlaA binds to flagellar assembly factor FliW protein, preventing FliW from binding to CsrA, so that CsrA can then bind flaA mRNA and represses its translation.
What are the official names of this protein?
Flagellin A.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: ZN579_HUMAN
Sequence: MDPQPPPPAQGSPPHRGRGRGRGRGRGRGRGRGRGGAGAPRAPLPCPTCGRLFRFPYYLSRHRLSHSGLRPHACPLCPKAFRRPAHLSRHLRGHGPQPPLRCAACPRTFPEPAQLRRHLAQEHAGGEVELAIERVAKETAEPSWGPQDEGSEPPTTAAAGATEEEAVAAWPETWPAGEPSTLAAPTSAAEPRESESEEAEAGAAELRAELALAAGRQEEKQVLLQADWTLLCLRCREAFATKGELKAHPCLRPEGEQEGEGGPPPRPKRHQCSICLKAFARPWSLSRHRLVHSTDRPFVCPDCGLAFRLASYLRQHRRVHGPLSLLAPLPAAGKKDDKASGARNSAKGPEGGEGAECGGASEGGEGQNGGDAAPARPPAGEPRFWCPECGKGFRRRAHLRQHGVTHSGARPFQCVRCQREFKRLADLARHAQVHAGGPAPHPCPRCPRRFSRAYSLLRHQRCHRAELERAAALQALQAQAPTSPPPPPPPLKAEQEEEGLPLPLANIKEEPPSPGTPPQSPPAPPVFLSASCFDSQDHSAFEMEEEEVDSKAHLRGLGGLAS
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 579.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RHMA_SHISS
Sequence: MNALLTNPFKERLRKGEVQIGLWLSSTTSYMAEIAATSGYDWLLIDGEHAPNTIQDLYHQLQAVAPYASQPVIRPVEGSKSLIKQVLDIGAQTLLIPMVDTADQARQVASATRYPPYGERGVGASVARAARWGRIENYMAQVNDSLCLLVQVESKTALDNLDEILDVEGIDGVFIGPADLSASLGYPDNAGHPEVQRIIETSIRRIRAAGKAAGFLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALDQRLAMFKSGKNGPRIKGSY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 2-keto-3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
What are the official names of this protein?
2-keto-3-deoxy-L-rhamnonate aldolase, KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
Protein: LARP4_MOUSE
Sequence: MLLFVEVTSKGTGLNPNAKVWQEIPSGNPDGTPVTEPSWHETAATSGSHPEGHTELSEDMCKEYEVMYSPSCETTRNTADVEESADGMILGPEDLSYQLYDVSGESSSAISTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTNTDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPVEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYTQPIQTPTQYPSPVFMQPVYNPQQYSVYSLVPQSWSPSPAPYFETPLAPFPNGSFVDGFSSPGSYKTNAAAMNMGRPFPKNRVKPHFRSSSGSEHSTEGSVSLGDGPLSRSSSRIFLSERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRRRDDDRIPRPQPAATEAKAPTPKFDLLATNFPPLPGSSSRVPDELGLENRMSDVVKGVCREKDSEDVRVSCPVPAEDGQTDCTSAPLSISPSPPCTAEPPVLSTTQQEQDQMEDSAVPKDTLNPVAVPVSSPTATKPSPANTASPCTSNINPPRAVALQEPRKLSYAEVCQKPPKEPSPVLVQPLRELRSNAVSPTRNEENGAPEKPVEKPHEKPETRASKDHSGFRGNTIPRGAAGKIREQRRQFSHRATPQGVTRRNGKEQYVPPRSPK
What is the function of this protein?
RNA binding protein that binds to the poly-A tract of mRNA molecules.  Associates with the 40S ribosomal subunit and with polysomes.  Plays a role in the regulation of mRNA translation.  Plays a role in the regulation of cell morphology and cytoskeletal organization.
What are the official names of this protein?
La-related protein 4, La ribonucleoprotein domain family member 4.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule. Cytoplasm, cytosol. Note=Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment.
Protein: DEF_LENCC
Sequence: MEKKTVAALSFLFIVLFVAQEIAVTEAKTCENLSDSFKGPCIPDGNCNKHCKEKEHLLSGRCRDDFRCWCTRNC
What is the function of this protein?
Has antifungal activity against the phytopathogenic fungus A. niger VKM F-2259, but not against A. alternata VKM F-3047.  Does not inhibit trypsin or chymotrypsin.
What are the official names of this protein?
Defensin Lc-def.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL28_STRTD
Sequence: MAKVCYFTGRKTVSGNNRSHAMNKTKRVVKPNLQKVTVLIDGKPKKVWASARALKSGKVERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ENGB_RHOPS
Sequence: MTDAINPTLIERGRKVFAGDWHFIWASPSIETLPPMAGIEVAFAGRSNVGKSSLINALTGRNALARTSNTPGRTQELIFFDGPTDAGLRLVDMPGYGYAAASKAKVASWTSLIHKFLQGRATLARVYVLIDGRHGLKDVDLDILKTLDKSAVSYQIVFTKADQVKAAELEQRIAATKTVLAKHPAAFPELLMTSSRTGAGMPELRAAMIRLLDERGA
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: PBCB_EMENI
Sequence: MSPPLDSALEPLSEYKETAFPRTEKDPSQYKEHDLVTPEKEIQTGYFSPRGSHSSHGSHDSSASSNISLDDARMSDVNNSPNVFHDDPDTIDEKLSMYWKAANETVIREPYDYIAGIPGKEIRRKLLEAFNHWYKVDEQSCQAIATTVGMAHNASLLIDDIQDSSKLRRGVPCAHEVFGIAQTINSANYVYFLAQNQLFRLRSWPQAISVFNEEMVNLHRGQGMELFWRDNLLPPSMDDYLQMIANKTGGLFRMIVRLLQTSSRQVIDVEQLVDVLGLYFQILDDYKNIREEKMAAQKGFFEDLTEGKFSFPICHAIGEGAKNRTALLHMLRLKTDDMKIKQEAVCILDNAGSLDYTREVLYGLDRKARSLLREFKTPNPFMEALLDAMLSSLQACH
What is the function of this protein?
Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD) (PubMed:22506079, PubMed:27098256).  Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors (PubMed:22506079, PubMed:27098256).  The geranylgeranyl pyrophosphate (GGPP) synthase AN1592 is needed in the formation of GGPP, the precursor for diterpenes (PubMed:22506079, PubMed:27098256).  Lastly, the pimaradiene synthase pbcA performs the 2 cyclization steps that convert GGPP to ent-pimara-8(14),15-diene (PubMed:22506079, PubMed:27098256).  The putative roles of the remaining cluster enzymes in ent-pimara-8(14),15-diene biosynthesis is unclear (Probable).  The cytochrome P450 monooxygenase AN1598, the glutathione S-transferase AN1595, the oxidoreductases AN1596 and AN1597 probably function as decorative enzymes (Probable).  It is possible that in biological conditions the compound is oxidized to ent-pimara-8(14),15-dien-19-oic acid, which is a bioactive diterpene compound predominant in many plant extracts (Probable).
What are the official names of this protein?
Geranylgeranyl pyrophosphate synthase AN1592, GGPP synthase, GGPPSase, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase, Pimaradiene biosynthesis cluster protein AN1592.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: PTH_SHISS
Sequence: MTIKLIVGLANPGAEYAATRHNAGAWFVDLLAERLRAPLREEAKFFGYTSRVTLGGEDVRLLVPTTFMNLSGKAVAAMASFFRINPDEILVAHDELDLPPGVAKFKLGGGHGGHNGLKDIISKLGNNPNFHRLRIGIGHPGDKNKVVGFVLGKPPVSEQKLIDEAIDEAARCTEMWFTDGLTKATNRLHAFKAQ
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_SALEP
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQVAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLEGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMAERFNMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLNVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLEDLADLDVLSTDDLKNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_STRM5
Sequence: MINITLPDGSRREFENPVSVMDVAQSIGAGLAKATIAGSVDGVLVDASDVIDHDASLRIITAKDEEGVEIIRHSSAHLVGHAVKQLYPDVKMVIGPVIAEGFYYDIYSERPFTPEDMAAIEKRMGELIAQDYDVIKKVTPRAEVIEIFKARGEDYKLRLIEDMSDDIQAMGMYYHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAQNEQLQRIYGTAWADKKQLEAYIKRIEEAEMRDHRRIGKQQDLFHLQEEAPGLVFWHPKGWALWQVVEQYMRKVYRKTGYGEVRCPQILDVSLWQKSGHWDNYQDAMFFTESEKRTYALKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGILRVRGFTQDDGHVFCTENQVEAEVTAFHQQALAVYQHFGFDEIQVKIALRPESRLGDDATWDKAEGALRSALSSNGVEWQELPGEGAFYGPKIEYHLKDAIGRTWQLGTMQVDFMMPGRLGAEYVDENSQKKHPVMLHRAIVGSMERFLGILIEHHAGQFPAWLAPTQVVVANITDAQAEYVSDVTKTLADQGFRVSADLRNEKIGYKIREHTLQRVPYLLVIGDREKENGAVAVRTRSGEDLGSMSLQAFIERLQAEGA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_MAGMM
Sequence: MRFSQTLIPTLKEEPSEAQVISHKLMLRAGLIRQLGAGIYTWLPMGLKVLRKVETIVRQEMDRAGAQEVLMPSIQPAELWEESGRWKMYGKELLRITDRHNRSFCYGPTHEEVISDLVRREIHSYKQLPANFYQIQTKFRDEVRPRFGIMRGREFLMKDAYSFDIDEAALDKSYRLMFEAYNKIFNRLDLKFRPVEADTGAIGGASSHEFHVLAQSGEDVIASCTHCQYAANLEKAFGIAVDLDGGVPEAMVRVATPGQKSIEEVAAFLKMDKARTVKCLTWHDPEADQWYLLLLRGDHTLNEVKACNATAPLAQIPAPEKAVEALGVAVGYLGAVGAEKFNKPVKILADSALRDVTNMVCGANEEGYHLTGVNWQRDLPKPEFVDLRNVEEGDGCPRCGPGSMELSRGIEVGHVFKLGYKYSEAMGVKVLDEDGKEKPLIMGCYGIGVSRIVAAAIEQNHDENGIIWPLAIAPFEVEVVVMNPNESDAMEKAEEITAQLQAGQLEVLLDDRDERAGSKFKDADLLGAPYRVLVGGRAFKEGVCEVKNRRSGVVEKIPVESVVETLLQWLAQEKKA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUEG_BACSU
Sequence: MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQLGDFVKINNQTSKTLFKDADITDETVSFNG
What are the official names of this protein?
Spore germination protein-like protein YueG.
What is the protein family that this protein belongs to?
Belongs to the GerPA/GerPF family.
Protein: CLPP_ALIF1
Sequence: MSYQENNAMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKKKLNTLLAEHTGQPLEVIEQDTDRDNFMSADDAVKYGLVDAVLNKRD
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUCI_ECOL6
Sequence: MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALLTEKLRHACGATVECVISDTCIAGMAEAAACEEKFSSQNVGLTITVTPCWCYGSETIDMDPTRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTSIPADVEEKLLRFARAGLAVASMKGKSYLSLGGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDENNKQYQRNAEQSRAVLRESLLMAMCIRDMMQGNSKLADIGRVEESLGYNAIAAGFQGQRHWTDQYPNGDTAEAILNSSFDWNGVRKPFVVATENDSLNGVAMLMGHQLTGTAQVFADVRTYWSPEAIERVTGHKLDGLAEHGIIHLINSGSAALDGSCKQRDSEGNPTMKPHWEISQQEADACLAATEWCPAIHEYFRGGGYSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKDVHDILNKRTNSTWPTTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLASMLRIPVCMHNVEETKVYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PALY_VITVI
Sequence: TDHLTHKLKHHPGQIEAAAIMEHILDGSSYVKEAKKLHEMDPLQKPKQDRYALRTSPQWLGPHIEVIRASTKSIEREINSVNDNPLIDVSRNKALHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGSRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVESAEQHNQDVNSLGLISSRKTAEAVDILKLMSTTYLVALCQAIDLRHLEENLKSTVKKTVSHVAKKTLTIGANGELHPSRFCEKDLLKVVDREHVFAYIDDPCSATYPLMQKVRQVLVEHALNNGESEKNGSTSIFQKIGAFEEELKAVLPKEVESARDGVESGNPSIPNRIKECRSYPLYKFVREELGTGLLTGEKVRSPGEDFDKVFTAMCEGKIIDPLLDCLSAWNGAPLPIC
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHH_PROM4
Sequence: MSQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTNVMFVPYVSRMDYAAGMFYEAIVVNAPERLAKISVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFRIGGVACDLPSGWLEKCTDFCKWFGPKIDEYEKLITNNPIFRRRIEGLGAISREEAINWSLSGPMLRASGVSWDLRKVDHYECYDDFDWSISTATEGDCFARYRVRIEEMRQSLKILLQACEMIPGGPTENLEASRMLEGKGSKFAGFDYQYVAKKVAPTFKIPDGELYTRLESGKGEIGVFIQGNNDVTPWRFKIRAADLNNLQILPHILKGAKVADIMAILGSIDVIMGSVDR
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase subunit H, NDH-1 subunit H, NDH-H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CLSA_PSESM
Sequence: MDYHDPYFFGYVLGFIHLLGTGAAIHALLTVRTSQGAIAWAMPLLFIPYFTLLPYLIFGRSSFDAYIKARREANKEMRAAIGSLNWRPWIEEAVAARRSDAYAALRAMPRLGNMPALANNKVRLLINGEETFGAIFQAIREAKQTILIQFFIIHDDNLGRQLQTLLLEKAAQGVAIFVLYDRIGSHALPGAYIDTLRDGGVQIKAFATRGGWLNRFQINFRNHRKIVVVDGLKGYIGGHNVGDEYMGLKPPLAPWRDTHVEVIGPVVACLQESFAEDWFWATRELPPLSLPDEFPEDGVLCQLLTSGPADAQETCSLFFVEAIHAAEERVWITSPYFIPDEAVSAALTLAVLRGVDVRLLLPSRPDHYVVYAASSLYAFDAVRAGVRVFRYEPGFLHQKVVLVDNDITAIGSANLDNRSFRLNFELMLLTVDSDFSSQVEAMLTADFAAAREISLQESHETRRLHQLGMRVARLISPIL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUOH1_CYTH3
Sequence: MEIPVEFLLEKTIIVTAVFTISLVIAMYSTYAERKVSALLQDRIGPNRAGPFGLLQPLADGVKFFMKEEIIPSSANKALFILGPSIAMMTACLTGAVIPWGSYLEIGGDQIALQVTDINIGVLYIFAVVSIGVYGVMIGGWASNNKFSLMGAIRASSQMISYEIAMGLSIIALVMTTGTLSIGEIVQQQTTDWWNIVYQPLGFFIFMVCSFAECNRTPFDLPECEAELIGGYHTEYSSMKLGLYLFAEYINMFISSAVMSAFYFGGYDIPYIETLGLDQNTVTILGTLFFFTKIVLFIFLFMWVRWTLPRFRYDQLMNLGWKIMIPMAIINIIITGACILLF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H 1, NADH dehydrogenase I subunit H 1, NDH-1 subunit H 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYC_PASSA
Sequence: ASFAEAPPGDKDVGGKIFKTKCAZCHTVZLGAGHKQGPNLNGLFGRQSGTTAGYSYSAANKNKAVLWABBTLYDYLLNPKKYIPGTKMVFPGLKKPQDRADLIAYLKHATA
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: ATG5_MAGO7
Sequence: MASPRRSEADLASPARGPGSGPPSPPHPGPDSARPLSRITSAAASPPPPGQRTAEPPTTISIPRTLWRLSIPLYITHPSLPNTPFITSLPRVSYLSLLLPRIRAFLPPSIPAPTSFHHEGIALRALPLGLLVDLYQPTLPWRLTVDQGDDWHVGDTFLNGVKEADFVRNGHAKQIMGMSKADTTALWNAVRDADYPAWARINARLLNPSTPIKHVPLRIYIPSSGGGGAGGATPAGSFRVMQTLVPPRTANRIPQTLGPTLRDLLPVLFPSSRDPVLANVVLHGAPVPFSAPLEGLMREAAYPDGWLCLTVVPL
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production.  Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).  Required for cell differentiation and pathogenesis.
What are the official names of this protein?
Autophagy protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: GPR6_HUMAN
Sequence: MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
What is the function of this protein?
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP.  Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).
What are the official names of this protein?
G-protein coupled receptor 6, Sphingosine 1-phosphate receptor GPR6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.
Protein: HLDE_BRASO
Sequence: MFDFDDLSQAIARQTVLCVGDLMLDEFVYGEVSRISPEAPAPVIAVQRSETNIGGAGNVARNIAALGARGIFVGLVGQDAAGDQLEAELAKVDGIESVLVRDPSRPTTRKVRFVSEHFSTHMLRADWERAAPASEDIEQKLIAAILPLIARADIVLLSDYAKGVLTARVLRNVIDATRRAGKRVIVDPKSANLAIYRGASVLTPNRKEFSEATRSRAETEQEIAAAAQDAIYLADCEAILVTQSERGMTLVPRQGDPIHVPAYPVKVRDVSGAGDTVVAVLAAALAAGAAWEDALRMASAAAAVAVSKQGTASVTSAELRRKILPHAYRAAEEKIIENDGELATRVAVWRSEGLRVGFTNGCFDILHPGHVKVLTAARAACDRLVVGLNSDTSVKRLKGESRPVQDERARAEVLAALEAVDLVAIFTEETPLRLIELVRPSVLVKGGDYTREQVVGHEVVEAAGGEVLLIDILKGHSTTALVDRARSDQR
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.