PharMolix/UniProtQA huggingface dataset:
Protein: AIS_SALTI
Sequence: MLAFTLRFIKNKRYFAILAGALVIIAGLASQHAWSGNGLPQINGKALAALAKQHPVVVLFRHAERCDRSDNTCLSDSTGITVNGAQDARALGKAFSADIQNYNLYSSNTVRTIQSATWFSAGRSLTADKKMMDCGSGIYASINTLLKKSQNKNIVIFTHNHCLTYIAKNKRGVKFDPDYLNALVMYAENGKLFLDGEFVPG
What is the function of this protein?
Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.
What are the official names of this protein?
Lipopolysaccharide core heptose(II)-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. Ais subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: HOOK_DROER
Sequence: MSAPKNEMYYSLLEWFKTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRLRMSNLKKVTQSVYDYYSDVLNYSLSDFSKPDLQSIAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQANIMRALQELEATRQASSAEGGVVSSLSRSSRTGNLDSKAVQEDRDALAQKCFETEKKMLLLIDEKTNLQQELHKLQQEFSRLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLHSEGAREDLKLKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLEGKNLALQRAKDSLLKERDNLREAVDELKCGQLSSNTALTGTTVSREMQPSATVEKLQRLEAENKALREGQGGQTALAQLLDDANKRCENLREQLKTANERILSLSHASQSDDPILKESEFGKQIKQLMELNEQKTLQLEEAVTQSTSLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRIASALDASVLEKSSDLVEEEPKPKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSGQTFLARQRQSAPRKSLSAMKSK
What is the function of this protein?
Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway.  Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton.  Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size.  Not involved in synaptic vesicle recycling.  Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs).  Has a role in regulating adult longevity.
What are the official names of this protein?
Protein hook.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Endosome. Synapse. Note=Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions.
Protein: MTNB_PODAN
Sequence: MTPPTTGLPAENTTDDNDHLVQSDDPEHPANLIPSLCAKFWTLGWVTGTGGGASIRDDDLVYLAPSGVQKELMKPSDIYVLSLAAQAQSLSRRQRVYLRSPPVYKPSQCTPLFLAAFTKRNAGCCIHTHSHWAVLVTLILEQQGSKEFRINNIEQIKGFGKGFQKSGNLGYHDTLVIPVIENTAHEEDLTEFLEEAMDKYPDTYAVLVRRHGVYVWGDNVHKAKTQCESLDYLFQLAVEMKQLGLPWITDIEPTIPTRKD
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_MYCTA
Sequence: MGIVGVGIDLVSIPDFAEQVDQPGTVFAETFTPGERRDASDKSSSAARHLAARWAAKEAVIKAWSGSRFAQRPVLPEDIHRDIEVVTDMWGRPRVRLTGAIAEYLADVTIHVSLTHEGDTAAAVAILEAP
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_PYRFU
Sequence: MLLPDWKIRKEILIEPFSEESLQPAGYDLRVGREAFVKGKLIDVEKEGKVVIPPREYALILTLERIKLPDDVMGDMKIRSSLAREGVIGSFAWVDPGWDGNLTLMLYNASNEPVELRYGERFVQIAFIRLEGPARNPYRGNYQGSTRLAFSKRKKL
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: TUSB_SALPA
Sequence: MLHTLPHCASGVDFPALLRLLKEGDALLLLQDGVTVAIEGNRFLESLRDAPITVYALKEDIDARGLGGQISDSVVRVDYTEFVRLTVKYANQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7S_BACC4
Sequence: MENKLSFEEAISQLEHLVSKLEQGDVPLEEAISYFKEGMELSKLCDEKLKNVQEQMAVILGEDGELEPFTALGDEA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_BACAA
Sequence: MKQIFIGIIRFYQKFISPMTPPTCRFYPTCSHYGLEAFQKHGAFKGFWLTCKRILKCHPFHPGGFDPVPDKKDDKVNS
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MIAA_GEOKA
Sequence: MAEKVAVIVGPTAVGKTKLGIALAKKLGGEVISGDSMQIYKGMDIGTAKVKPDEMEGIPHHLLDIKEPCEPFSVVEFQRLCRALITEISARGRLPIIVGGTGLYIQAALYDYQFSAAPSDEAYRRALKQLAAEQGAEALHRRLEAVDPISAARIHPHNIRRVIRALEVYHCTGKPFSEWQQGQSKRLLYEAAIVGLTAEREALYRRINERVDEMIAAGLIEEARALYDRGLRDCQAVQAIGYKELYDYFDGRVSLDEAIEQLKQNSRRYAKRQLTWFRNQMPVKWFDMTDAGQFAAKVEEISRYVAGKLQLEANI
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: TBC24_BOVIN
Sequence: MHPPAYNCFVDRDKMDSAIPDLGPKELSCTELQELKQLARQGYWARSYALRGQVYQRLIRDIPCRTVTPDASVYRDIVGKIVGKHSSASLPLPEFVDNTQVPSYCLNSKGEGAVRKILLCISNQFPDVSFCPALPAVVALLLHYSADEAECFEKACRILACNDSSRKLVDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYADWQRWLFGELPLSYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRAFVRDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALKQKGITVKQKSVSLSKRQFVHLAVHADNFHSEIVGVKEMRDIWSWVPERFALCQPLLLFSSLQHGYSLTRFYFQCEGREPTVLLIKTTQKEVCGAYLSTDWSERNKFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHPELTKPAPLEPTTVPPSPSHSVSSEPADRLSPFLATRHFNLPSKTESLFMAGGSDCLIIGHVAGDWR
What is the function of this protein?
May act as a GTPase-activating protein for Rab family protein(s).  Involved in neuronal projections development, probably through a negative modulation of ARF6 function.  Involved in the regulation of synaptic vesicle trafficking.
What are the official names of this protein?
TBC1 domain family member 24.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasmic vesicle membrane. Presynapse. Note=Mainly cytoplasmatic with partial expression at the plasma membrane (By similarity). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).
Protein: RL13_NITSB
Sequence: MKFTRMVKPNEVERKWHVIDAEGKTFGRLVTEIATLLRGKHKPNYTPHVDCGDYVVVINASKVKVSGNKESKEYHRHTGYFGGVKSEKLAELREKNPEKLFKLATRGMLPKTKLGRAMLKKLKVYPGSEHPHTAQVKGN
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PANB_CLOBA
Sequence: MKNTIATFQEFKNKGKKISMLTAYDYSMAKIIDESGINGILIGDSLGMVIKGEEDTLSVTVDEIIYHTKSVKKGAKNALIVSDMPFLSYHTSVEEAVKNAGKMIKEGGANAVKLEGGASVIKQIKAIVDAQIPVMGHLGLTPQSVNAFGGFKIQGKSEEAAKRLIEDAKLIEDAGAFAIVLECVPKKVAEIITKEISIPTIGIGAGNECDGQILVYQDMLGMFDDFIPKFVKQYANLGAQMREAIQIYIGEVGEGSFPQDKHSFKIDEKELQKLY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EBSL_ARATH
Sequence: MAKTRPGVAFSSKIKLGKKDIKILGREILLGNVIVEVGFFTVGDCVLMRPSDAGKAPYVARVEKIEADARNNVKVHCRWYYCPEESHGGRRQLHGAKELFLSDHFDVQSAHTIEGKCIVHTFKNYTRLENVGVEDYYCIFDYKAATGAFTPDRVAVYYKCEMPYNSDELMELLLCHYRVHLACVGVTIEEAKKLEHFVCVECSSDEDGVKRFQNGFASSTTNDLKPSAEKMIDVRASYEL
What is the function of this protein?
Chromatin remodeling factor that binds to methylated histone (e. g.  H3K4me2/3) to prevent their acetylation (e. g.  H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulate the transcription of target genes.
What are the official names of this protein?
Chromatin remodeling protein At4g04260.
What is the protein family that this protein belongs to?
Belongs to the SHL1/EBS protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHIZ_MYCTU
Sequence: MTPVRPPHTPDPLNLRGPLDGPRWRRAEPAQSRRPGRSRPGGAPLRYHRTGVGMSRTGHGSRPVPPATTVGLALLAAAITLWLGLVAQFGQMITGGSADGSADSTGRVPDRLAVVRVETGESLYDVAVRVAPNAPTRQVADRIRELNGLQTPALAVGQTLIAPVG
What is the function of this protein?
Cell wall hydrolase that modulates cell division process (PubMed:22094151, PubMed:16942606).  Probably acts by modulating FtsZ ring assembly (PubMed:16942606, PubMed:22094151).  Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis (PubMed:16942606).  Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ (PubMed:16942606).
What are the official names of this protein?
Cell wall hydrolase ChiZ.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Localizes at poles and at midcell regions.
Protein: RR2_OCHNE
Sequence: NLVDIPIPANDDAIKSIKLIVSKLSTGIQQGQSY
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TEX44_HUMAN
Sequence: MALPGYPLGNVDDSRSKDSPAGEPQGQVPLTADVLAVSSSVASTDWQDIDQASFKTATPRAISTSGDKDKSAVVPEHGQKTPRKITPLLPSQNPSPLQVSMSLQNPAWDRQVQDARTSQSLVVFPSHLLGKDKMSQMASVPEREPESAPSAPSAELQSTQHMEAQPVESDADHVTAGANGQHGPQAASTTKSAEEKAEHPKAPHPEAEALPSDESPVAMGANVVDSLGDLQTWFFPPPPAGSVSPSPGPHEVALGRRPLDSSLYTASEENSYMRSMTSLLDRGEGSISSLADILVWSETTMGMAIATGFLDSGHSTVADLLHSSGPSLRSVPSLVGSVSSAFSSGLVSGTSSALRTITRVLETVEQRTVEGIRSAMRYLTSHLTPRQAQADPNYD
What are the official names of this protein?
Testis-expressed protein 44.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_STAAN
Sequence: MNLKQEVESRKTFAIISHPDAGKTTLTEKLLYFSGAIREAGTVKGKKTGKFATSDWMKVEQERGISVTSSVMQFDYDDYKINILDTPGHEDFSEDTYRTLMAVDSAVMVIDCAKGIEPQTLKLFKVCKMRGIPIFTFINKLDRVGKEPFELLDEIEETLNIETYPMNWPIGMGQSFFGIIDRKSKTIEPFRDEENILHLNDDFELEEDHAITNDSAFEQAIEELMLVEEAGEAFDNDALLSGDLTPVFFGSALANFGVQNFLNAYVDFAPMPNARQTKEDVEVSPFDDSFSGFIFKIQANMDPKHRDRIAFMRVVSGAFERGMDVTLQRTNKKQKITRSTSFMADDKETVNHAVAGDIIGLYDTGNYQIGDTLVGGKQTYSFQDLPQFTPEIFMKVSAKNVMKQKHFHKGIEQLVQEGAIQYYKTLHTNQIILGAVGQLQFEVFEHRMKNEYNVDVVMEPVGRKIARWIENEDQITDKMNTSRSILVKDRYDDLVFLFENEFATRWFEEKFLEIKLYSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity).
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIQ_CERCA
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG
What is the function of this protein?
Ubiquitin exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Ubiquitin.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NUOB2_RHIME
Sequence: MAGVNDAIRDSVLFTTADSIISWSRRSALWPETFGIACCAIEMISAGCARYDLDRFGVVFRPSPRQSDVMIIAGTVTRKFAPVVRRLYDQMPEPRWVIAMGTCAISGGVYNTYAVVQGSETFVPVDVHVPGCPPRPEALMHGFLLLQEKIKKSRALTGTPLGRVIAS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 2, NADH dehydrogenase I subunit B 2, NDH-1 subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BROMI_DANRE
Sequence: MSQFSTEDEAELQTLLRKLLKSVKDRISGAPSVECAEEILLHLEETDKNFHNYEFVKYLREYVESSLGAVIEVETENFTKGEGHAVGSGQDTLVHAVTKNTRESTQYKQMMQTLKQTMMMVVESLINKFEEDQMKREEMDRKIQHQQSISQYADNCSDSDSSFNQSYAFIKHEQLQVIAEKLDPGRPREVRWEALQSLCHAPPSDVLSCESWTGLRRNLSTALTDPDPELSDKVLQFFAKTFSSSPLNVTKDIYASIGNTKTLEAHFLYHKLSFPSGTTSIDANRPDMARLLKQMRLMNDFQKEVTTFWIRHPEKYMEEIIENTLSLLALHSEQGMSSPGSEKSLEPIHLISLLDIKATWFKKWMHGYYSRTVVLRLLERKYKSLIVNALQQCIYYFDSCDALSEETLEMIHSLEHQQIGPAGRTLYTSKELEFVYFVHSLCVLGRLVMYTNGRKFFPIKVKKRRDPVTLTDLVVILINIMYQHPKPSCGETALADTMSPTNLVMEVLRTLCDRTECAVECLYQIPVIETLLAPLITLLTGKLPKLNSMESALTHTADTLARIATTERGLSLLLYDRNLVSAEGESISAAHLIVQFTQKLLAKELQVENSSSMSGAFIFVCRQMYNTCEGLQVLRPYSLHECIAQAWRTTSSMSERVPTPVPGAPPALASQELQSVVAWEEMLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRCEKFGYGVMVTQVATTAPGIVALQSSGFVQTIVVELWSALECGREDVRVVHPKSTPMDPIDRSCLKSFLSLVNLLSSPHAVWELLGHRALPNKTEYNLREMATSVLDLMDRLIIINSDAKIHSLFNYEQSHTFGLRLLSVLCCNLDSFLLLESQYKLTDLLLQGQRDNVTEPPSGEGEFIIDGLSVERNHILVRICAVGGPSERKLPPRALQKGNDPYPWPMVSTYPLPKYYIFDVPKILRTKQESEIGAFLTSSKETERDASWMDDCRRQFCKIMATKSNTLTGYVLADLLEMVVLHLSSSSNDCFFPPAEYKVVDNSVKTRSLSSVEQLGVEISLRYGKFLKLLREDSEQDLCLLLKHCQEFLSQQRVKVTSELCGYPGHDWFASTVFLLMHGDVGRSLSLLLRFSRLLPSAFLWPPRLHSSVHLPIEIAQSAIHPIYSCTAHYVEMLLKAEVPLVFSAFRMSGFTPSQICVQWLGQCFWNYLDWPEICQYVTTCVIMGPDYQVYMCVSALRHLQQDILQHTQTQDLQVFLKEEPIQGFRVSNYLEYMEGLERSYRSMVLSDMRSILPRSS
What is the function of this protein?
Required for high-level Shh responses in the developing neural tube.  Together with cdk20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.
What are the official names of this protein?
Protein broad-minded, TBC1 domain family member 32.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium.
Protein: RUVB_SHESW
Sequence: MIEADRLIQPQLQVQDDVVDRAMRPKLLDEYTGQDDTRAQLKVFIQAAKNRNEALDHMLIYGPPGLGKTTLAMIVANEMGVNIKSTSGPVLEKAGDLAALLTNLESGDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGALTSPLRARFGIPLRLEFYNIKDLSTIVTRSAQVMGLEIDTEGAFEIARRSRGTPRIANRLLRRVRDYAEVKHDGAITQFVADHALDLLDVDNEGFDYMDRKLMLAIIDKFMGGPVGLDNLAAAIGEERETIEDVLEPFLIQQGFIQRTPRGRIATARAYQHFQLIKPE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PURR_SALPC
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLSMLEEYRHIPMVVMDWGEAKADFTDTVIDNAFAGGYMAGRYLVERGHRDIGVIPGPLERNTGAGRLAGFMKAMEEALINVPDNWIVQGDFEPESGYHAMQQILSQSHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSVIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREESQSIEVHPRLVERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: TRMA_ECO27
Sequence: MTPEHLPTEQYEAQLAEKVVRLQSMMAPFSDLVPEVFRSPVSHYRMRAEFRIWHDGDDLYHIIFDQQTKSRIRVDSFPAASELINQLMTAMIAGVRNNPVLRHKLFQIDYLTTLSNQAVVSLLYHKKLDDEWRQQAEALRDALRAQNLNVHLIGRATKTKIELDQDYIDERLPVAGKEMIYRQVENSFTQPNAAMNIQMLEWALDVTKGSKGDLLELYCGNGNFSLALARNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKSYQCETIFVDPPRSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHKVERLALFDQFPYTHHMECGVLLTAK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: H4_USTMA
Sequence: MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYDETRGVLKLFLESVIRDSVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RSMH_POLSJ
Sequence: MQDTWTHRTVLLNEAIAALHINPDGHYIDATFGRGGHSRLLLSQLSPQGRLTAFDKDLDAIAEAQTITDPRFSIRHEGFMHLGQLPAASAAGVLMDLGVSSPQIDNPVRGFSFRSEGPLDMRMDTTRGQSVAEWLADASIETMAEVIREYGEERFAQQVAKAIDRRRQERGPLRTTAELAEVVAGAVKTREPGKDPATRTFQALRIFINAELEELQQALEASLKVLQPGGRLVVISFHSLEDRIVKQFIAGQSREVFDRRAPFAAPKAMRLKALGRIKPSEEEIAANPRSRSAVMRVAERTGVSA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPS5_ARATH
Sequence: MMIAQELGIYVVESKGGAILCLLLSLLCLGTWPALMALLERRGRLPQHTYLDYSITNFLAAIFIAFVFGGIGESTHEAPSFITQLTQIQDNWPSVLFAMAGGVGLSIGNLATQYSLAFVGLSVTEVTAASITVVVGTTVNYFLDNGLNRADILFSGVGCFMVAVCLGSAVHSSNSADIKAKLGKLSGDCETVTPEECQRLFGVEEEEEEEKEMENVKEGSAAFLIALENKRAIKVLGKSMVVGLGITFFAGLSFSLFSPLFNLATNDQWHTLKQGVPKLIVYTAFFYFSLSCFVIAVALNISFLYKPVLDSPRSSFREYLSDWNGRGWALAAGLLCGFGNGLQFMGGQAAGYAASDAVQALPLVSTFWGIYLFGEYRRSSTRTYALLVGMLVMFTVAVGLLMASAGERETRFT
What is the function of this protein?
Proton-coupled transporter that transports a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, xanthine and uracil.
What are the official names of this protein?
Ureide permease 5, AtUPS5.
What is the protein family that this protein belongs to?
Belongs to the plant ureide permease (TC 2.A.7.19) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.