PharMolix/UniProtQA huggingface dataset:
Protein: TM53A_XENLA
Sequence: MGDSELDYTIEFPEPSLQGWPWDPEREPVVILLGWGGCKDHYLAKYSAIYHNQGCTVIKYTAAWKAVFITESLGLNSLREDAKKLLELLFDYEIEKSPIVFHVFSNGGFMLYRYIVELLHSHCPLNKLHVVGTIFDSAPGNRNVIGSVRALDTILRTSTNKAFRFLALAAFAILVIILRILLYPLTRFLHENHYDAMKKDPSRWPQLYLYSRADPIISYLDVESMIAARRRRCLPTETLDFGKSEHVSHFRRFPQRYSEICTSFLRDCVRKASISMLRSEHPVSF
What is the function of this protein?
Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD proteins.
What are the official names of this protein?
Transmembrane protein 53-A.
What is the protein family that this protein belongs to?
Belongs to the TMEM53 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DRL17_ARATH
Sequence: MGCCFSVQFSFDDQTLVRIFNFLCGNINRNSFGVEERPTQPTIGQEEMLEKAWNRLMEDRVGIMGLHGMGGVGKTTLFKKIHNKFAKMSSRFDIVIWIVVSKGAKLSKLQEDIAEKLHLCDDLWKNKNESDKATDIHRVLKGKRFVLMLDDIWEKVDLEAIGVPYPSEVNKCKVAFTTRDQKVCGEMGDHKPMQVKCLEPEDAWELFKNKVGDNTLRSDPVIVELAREVAQKCRGLPLALSVIGETMASKTMVQEWEHAIDVLTRSAAEFSNMGNKILPILKYSYDSLGDEHIKSCFLYCALFPEDDEIYNEKLIDYWICEGFIGEDQVIKRARNKGYEMLGTLTLANLLTKVGTEHVVMHDVVREMALWIASDFGKQKENFVVRARVGLHERPEAKDWGAVRRMSLMDNHIEEITCESKCSELTTLFLQSNQLKNLSGEFIRYMQKLVVLDLSYNRDFNKLPEQISGLVSLQFLDLSNTSIKQLPVGLKKLKKLTFLNLAYTVRLCSISGISRLLSLRLLRLLGSKVHGDASVLKELQKLQNLQHLAITLSAELSLNQRLANLISILGIEGFLQKPFDLSFLASMENLSSLWVKNSYFSEIKCRESETASSYLRINPKIPCFTNLSRLGLSKCHSIKDLTWILFAPNLVYLYIEDSREVGEIINKEKATNLTSITPFLKLERLILYNLPKLESIYWSPLHFPRLLIIHVLDCPKLRKLPLNATSVPLVEEFQIRMYPPGLGNELEWEDEDTKNRFVLSIKK
What is the function of this protein?
Probable disease resistance protein.
What are the official names of this protein?
Probable disease resistance protein At1g61300.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PHNX_KLEP7
Sequence: MNRISALILDWAGTTVDFGSFAPTQIFVEAFRQAFDIEITLEEARVPMGLGKWQHIEALGKLPAVDSRWQAKFGRAMTAADIDAIYAAFMPLQIAKVVDFSAPIAGVVDTIAALRAKGLKIGSCSGYPRPVMEKLVPAAAAQGYAPDHWVATDDLAAGGRPGPWMALQNVITLGIDDVAHCVKVDDAAPGISEGLHAGMWSVGLAVSGNEFGATWEEYQAMSKAEIATRRERAAGKLYAAGAHYVVDTLADLPEVIADINARLAKGERP
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
Phosphonoacetaldehyde hydrolase, Phosphonatase, Phosphonoacetaldehyde phosphonohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PhnX family.
Protein: APT_SHIBS
Sequence: MTATAQQLEYLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIDLLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPGKLPRETISETYDLEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVADAAFIINLFDLGGEQRLEKQGITSYSLVPFPGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_LEGPA
Sequence: MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVRSSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQLGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQRPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQGVGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDVLSLSDELLLMDIYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTOX_ECOLI
Sequence: MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGDTRLIRHAYGEGEKYVPLVLRAQTLWDELSRHNEEDPIFVRSGVINLGPADSTFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWIQLAKEAGCAQLFNCPVTAIRHDDDGVTIETADGEYQAKKAIVCAGTWVKDLLPELPVQPVRKVFAWYQADGRYSVKNKFPAFTGELPNGDQYYGFPAENDALKIGKHNGGQVIHSADERVPFAEVASDGSEAFPFLRNVLPGIGCCLYGAACTYDNSPDEDFIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSRFQ
What is the function of this protein?
Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.  Can also use other N-methyl amino acids, including sarcosine, which, however, is a poor substrate.
What are the official names of this protein?
N-methyl-L-tryptophan oxidase, MTOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MTOX subfamily.
Protein: AMPA_ACIC5
Sequence: MKTTLVSTPLAQLETELLAVFATDTAPAADMANGTQASPQVQLLTRDAALDAAVKTILASGDFKAEANETLLIHAPQGMAARRLLLVGAGKQARFTVHALRKAAGSAVRAARAKNIREATLAIPQSQGLDVTATARALGHGAAVADFDPDFYRSDRKDKSLQSLTLALPEATDANAAEAGLREGIALGESQNLTRTLVNEPGNRLTPTLLGEQAKKMCAEQGLRCQVYSSEKLHELKMGSFWSVTQGSDEPPALIVMEYTPEGAAEGPVLGLVGKGITFDSGGLSLKPADSMEKMKYDMAGAAAMIGAMRAIALLKPRIKVISVICSAENMPSGKAQKPGDVQISMIGKSIEVLNTDAEGRLVLADGLAYAKQLGATHLIDAATLTGAVMVALGGVNAGVFCNDEEAWQHFEAALGQSGEKFWRLPLDEEYREMLRSPIADIKNVGGRYGGASTAAMFLKEFVGDTPWVHLDIAGTAWMDEAKPWMSSGPSGIAMPSIVEWVRSFAR
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_HELHP
Sequence: MAHKKGQGSTQNNRDSAGRRLGVKRFGSQFVRAGNIIVRQRGTKVHPGDNVGLGKDHTIYALIDGVVKFQQKDKNRKKVSVIPAS
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: NHAB_SALNS
Sequence: MEISWGRAMWRNFLGQSPDWYKLALLVFLIINPFIFLANPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMTSAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLVCGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKIKLIVQAVIGVWLVTALALHLAEVGLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLSSISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTLIGLLCVEFTLAPATEWMTQAGWLATLS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FQRL3_ARATH
Sequence: MAVTKIYIVYYSLHGHVETMAREVLRGVNSVPDVEATLWQVPETLPEKILEKVKAVPRPDDVPDIRPEQLAEADGFMFGFPSRFGVMASQVMTFFDNTNDLWTTQALAGKPAGIFWSTGFHGGGQELTALTAVTKLAHHGMIFVPVGYTFGKSMYEMGEVKGGSPYGSGTYAADGSREPTELEIQQANYHGKYFAGIAKKLKKRSPV
What is the function of this protein?
Catalyzes the transfer of electrons from NADH and NADPH to reduce quinone to the hydroquinone state.
What are the official names of this protein?
Probable NAD(P)H dehydrogenase (quinone) FQR1-like 3.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: GNA1_ORYSJ
Sequence: MEQPLPTAAAEAAAAGGDGEAYRIRPLELADISRGFLGLLNQLSPSPPLTEEAFRARFEELAALGADHLVLVAEDAATGRLAAAGAVLVERKFIRRCGRVGHVEDVVVDAAARGRGLGERVVRRLVEHARGRGCYKVIINCTPELTGFYAKCGFVEKNVQMGLYF
What is the function of this protein?
Acetyltransferase involved in de novo biosynthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) in roots and is required for maintaining normal root cell shape.  UDP-GlcNAc is an essential metabolite that serves as an initial sugar donor for N-glycan synthesis and thus plays an important role in protein and lipid glycosylation.
What are the official names of this protein?
Glucosamine 6-phosphate N-acetyltransferase 1, Glucose-6-phosphate acetyltransferase 1, OsGNA1, Phosphoglucosamine acetylase 1, Phosphoglucosamine transacetylase 1.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. GNA1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: Y599_STAAC
Sequence: MKKIMITGALGQIGTELVVKCREIYGTDNVLATDIREPEADSPVQNGPFEILDVTDRDRMFELVRDFEADSLMHMAALLSATAEKNPILAWDLNMGGLMNALEAARTYNLHFFTPSSIGAFGDSTPKVNTPQVTIQQPTTMYGVNKVAGELLCQYYFKRFGVDTRSVRFPGLISHVKEPGGGTTDYAVEIYFKAVREGHYTSFIDKGTYMDMMYMDDAIEAIIKLMEADDAKLETRNGYNLSAMSFDPEMVKEAIQEYYPNFTLDYDVDPIRQGIANSWPDSIDTSCSRGEWGFDPKYDLASMTKLMLEAIEQKDTVKNNN
What are the official names of this protein?
Uncharacterized epimerase/dehydratase SACOL0599.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: RNC_STRS7
Sequence: MKKLEALLENSFNIRFDDKRLLETAFTHTSYANEHRLLNISHNERLEFLGDAVLQLIISEYLFAKYPKQTEGDMSKLRSTIVREESLAGFSRYCSFDAYIKLGKGEEKSGGRHRDTILGDLFEAFLGALLLDKGIEEVRRFLNQVMIPQVEQGTFEKVKDYKTCLQELLQAKGDVVIDYQVISETGPAHAKQFEVAVLVDEDRLSKGTGRSKKLAEQDAAKNALAQLSEV
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_XANCP
Sequence: MSRKGSTPQRTVLPDPKHGSETIARFINMVMQSGKKSVAEKIVYGAMDVIGEKNPNAVELVQKALDNVAPAVEVKSRRVGGATYQVPVEVRSSRRMALAMRWLIDSARKRGENTMPRKLAAELLDASESRGGAIKKREETHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ATL1_ARATH
Sequence: MDLTDRRNPFNNLVFPPPPPPPSTTFTSPIFPRTSSSGTNFPILAIAVIGILATAFLLVSYYIFVIKCCLNWHQIDIFRRRRRSSDQNPLMIYSPHEVNRGLDESAIRAIPVFKFKKRDVVAGEEDQSKNSQECSVCLNEFQEDEKLRIIPNCCHVFHIDCIDIWLQGNANCPLCRTSVSCEASFTLDLISAPSSPRENSPHSRNRNLEPGLVLGGDDDFVVIELGASNGNNRESVRNIDFLTEQERVTSNEVSTGNSPKSVSPLPIKFGNRGMYKKERKFHKVTSMGDECIDTRGKDGHFGEIQPIRRSISMDSSVDRQLYLAVQEEISRRNRQIPVAGDGEDSSSSGGGNSRVMKRCFFSFGSSRTSKSSSILPVYLEP
What are the official names of this protein?
RING-H2 finger protein ATL1, RING-type E3 ubiquitin transferase ATL1.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MRAY_STRPJ
Sequence: MFISISAGVVTFLITLVGIPAFIQFYRKAQITGQQMHEDVKQHQAKAGTPTMGGLVFLIAAVVVSFLLALFSKQLTNNVGMILFILVLYGLVGFLDDFLKVFRKINEGLNPKQKLALQLLGGVIFYLFYERGGDMLSVFSYQVHLGIFYIIFALFWLVGFSNAVNLTDGIDGLASISVVISLSAYGVIAYVQGQMDILLVILAMIGGLLGFFVFNHKPAKVFMGDVGSLALGGMLAAISMALHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKRIFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLTLAILYLM
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPB2_CERS4
Sequence: MTGRVTSVRGPVLDIRVEGPLPAIGDVVEVGSLPVVAEIQAHLGAADVRAIALHSTQGIARGETVRTTGGPLRVPTGPAVLGRLLDVAGRPADLGPPIPAGAPRAPILHPAPPLAAQDARFQVFSTGIKVLDLLAPLAQGGKTAMFGGAGVGKTVLVMELIRAMVSGYDGISVFAGVGERSREGHEMLGEMKASGVLDRTVLVYGQMNEPPGARWRVPLTALTIAEGFRDGEGRNVLLLIDNVFRFVQAGAEVSGLLGRMPSRVGYQPTLETEVAALQERIASVGRASVTAIEAVYVPADDFTDPAVTAISAHVDSTVVLSRQLAAEGIYPAIDPLATTSVLLDPAVVGEEHARVAGRLKEAIEHYHELRDVIALLGIEELGREEQLMVGRARKLQRFLTQPFFVAAAYTGMEGRSVPVAETVQGCAAILGGECDDWDEGSLYMIGTLAEARAREEARRRKGAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 2, ATP synthase F1 sector subunit beta 2, F-ATPase subunit beta 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RLMF_SALSV
Sequence: MSAQKSGLHPRNRHQHRYDLAALCQTTPELTSFLIRTPAGEQSVDFANPQAVKALNKALLAHFYAVTHWDIPPGFLCPPVPGRADYIHHLADLLGETTGSIPAQATILDVGVGANCIYPLIGVHEYGWRFTGSEVSDAAMSSAQAIIQANTGLSRAIRLRRQKDPAAIFTGIIHKNEFYDATLCNPPFHDSAAAARAGSERKRRNLGQNKDDALNFGGQQQELWCEGGEVAFIKKMIAESQSFRRQVLWFTTLVSRGENLPPLYRALTEAGAVKVVKKEMAQGQKQSRFIAWTFMDDDQRRRFITRKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YMFK_BACSU
Sequence: MKGVYHLAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSRRGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTFRFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCASKRWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERHLQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMFDQSGFSSFDF
What are the official names of this protein?
Uncharacterized protein YmfK.
Protein: DBND2_HUMAN
Sequence: MGAGNFLTALEVPVAALAGAASDRRASCERVSPPPPLPHFRLPPLPRSRLPGPVSRPEPGAPLLGCWLQWGAPSPGPLCLLFRLCSCTCFAPLPAGADMDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLESQRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMDNHLEELSLPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGACS
What is the function of this protein?
May modulate the activity of casein kinase-1.  Inhibits CSNK1D autophosphorylation (in vitro).
What are the official names of this protein?
Dysbindin domain-containing protein 2, Casein kinase-1 binding protein, CK1BP, HSMNP1.
What is the protein family that this protein belongs to?
Belongs to the dysbindin family.
Protein: DRS7C_BOVIN
Sequence: MGVTAVLMLPLLLLGISGLLFIYQEVSRLWSKSVVQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLQSLYDALISVADPSKTFTPKLVLLDLSDISCVQDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPIILTKALLPDMISRRTGQIVLVNNIQGKLGIPFRTAYAASKHAALGFFDCLRAEVEEYDVVVSTVSPTFIRSYHVDPGQGNWEASIWKFFFRKLTYGTHPVDVAEEVMRTVRRKKQEVFLANPIPKAAVYIRTLFPELFFAVVACGVKEKLSVPEEG
What is the function of this protein?
NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal.  Plays a role in the regulation of cardiac and skeletal muscle metabolic functions.  Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal.  Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes.  Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid.
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 7C, Sarcoplasmic reticulum protein of 35 kDa, Protein SRP-35, Short-chain dehydrogenase/reductase family 32C member 2, Protein SDR32C2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane. Note=The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. In skeletal muscle, enriched in the longitudinal sarcoplasmic reticulum.
Protein: GLN1A_STAAM
Sequence: MPKRTFTKEDIRKFAEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMMFDGSSIEGFVRIEESDMYLHPDLDTWVIFPWTAGQGKVARLICDVYKTDGTPFEGDPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELNDDGGYFDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKYADAVTACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLFKGKENAFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVPGYEAPCYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAILEAGLDGIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMRENEVIKKALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY
What is the function of this protein?
Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism.  It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.  Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA.  During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation.  Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity.  In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I alpha, GSI alpha.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1546_HAEIN
Sequence: MNNQTLATQYEMDFSYNPLPFFSDIEDNLKFNKKLDLNLYCIKRPKQTCFIHITNPNMLAWGIESGDMLVVEKNDDLYSGDLVVLEENNEFHVYEFMAHSGNYLFMALDSTTQNINTKRLVKFTYYRHRDQYDSSNETSR
What are the official names of this protein?
Uncharacterized protein HI_1546.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: IF2_BACCZ
Sequence: MSKIRVHEYAKKHNISSKDLMTKLKEMNIEVSNHMTMLDDEVVNKLDNEYQAEKPSVADEFEVEEKVVRSKKNSNKKKKKGKGNEDKRQENFAGRQQTQTVETPDKITFSGSLTVGDLAKKLSKEPSEIIKKLFMLGIMATINQDLDKDTIELIANDYGIEVEEEVIVSETEFETFIDEQDDEENLKERPAVVTIMGHVDHGKTTLLDSIRNSKVTAGEAGGITQHIGAYQVEVNDKKITFLDTPGHAAFTTMRARGAQVTDITILVVAADDGVMPQTVEAINHAKAAGVPIIVAVNKMDKPAANPDRVMQELTEYELVPEAWGGDTIFVPISAIQGEGIDNLLEMILLVSEVEEYKANPNRYATGTVIEAQLDKGKGTIATLLVQNGTLRVGDPIVVGTSFGRVRAMVSDIGRRVKVAGPSTPVEITGLNEVPQAGDRFMAFADEKKARQIGESRAQEALLAQRGEKSKLSLEDLFQQIQEGDVKEINLIVKADVQGSVEAMAASLRKIDVEGVKVKIIHTGVGAITESDIILASASNAIVIGFNVRPDVNAKRTAELENVDIRLHRIIYKVIEEIEAAMQGMLDPEFEEKVIGQAEVRQTFKVTKVGTIAGCYVTDGKITRDSGVRIIRDGVVIFEGQLDTLKRFKDDVKEVAQNYECGITIERYNDLKEGDIIEAYIMEEVKR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURJ_TREPA
Sequence: MKSKSSLLKSGLLLSLLTLVSRVLGLAREVVKSTLMGTSATADAFTVAFMIPNLFRRLFAENAISVAFIPVFTQHYSMPSSAQVPCSSKTKEFLSAIFTLMSSVTASISLIGILGAPYIVRLFDTDQSLTVSLTRLMFPYLWMISLAAFFQGMLHSIKVFVPSGCTPIFFNVSVIFSMYFLNVSHMNVAIAAAIGVLIGGCAQALFQLIFVYMHGFRFTLQSPLKAMHDEGVRRIIALLLPTTVGIATYLLNDLVCTALATSVEIGVAASVQYSLRIQELLLGIFIVSLSSVVLPDLSFHVMRKDWQSFEDLLITAIKIVMLITIPATFFVLFSSDRIITLVYKNAIFNELSVRMTATIFRWHSVGMLAIALNRVLISAFYAQHNSFAPMIAGTISFVTNIILATLLFIPLGGKGIAFSLSAASMVQTVFLWMFLKRSWQITIPSLYKTSLYYGVKITLFSVIALVPTWASSFFTAYFFPGSHKIISHGVPLCVEALIFSCTGCILLLLSRDEFAYKALRSIRFCR
What is the function of this protein?
Involved in peptidoglycan biosynthesis.  Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
What are the official names of this protein?
Probable lipid II flippase MurJ.
What is the protein family that this protein belongs to?
Belongs to the MurJ/MviN family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU2M_ANAAC
Sequence: MNPHATPVLVLSLALGTTITISSNHWVLAWTGLEINTLAIIPLISKSHHPRAVEAATKYFLTQAAASALVLFSSMTNAWATGQWDITQLNHPTSCLLLTAAIAIKLGLVPFHFWFPEVLQGSPLMTALLLSTLMKFPPLTLLLMTSKSLNPALLTAMALASAALGGWMGLNQTQTRKILAFSSISHLGWIAIILVYSPKLALLTFYLYTIMTSAVFMALNKIKALNLSMVLTSWTKTPVLNATLMLVLLSLAGLPPLTGFMPKWLIIQELTKQEMTPAAMAIAMLSLLSLFFYLRLAYHSTITLPPNSSNHMKQWYTSKPPSTPTAILASLSILLLPLSPMIHAIV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PDXH_ACICJ
Sequence: MRRLGLSNIATRKREQPMIDISADPFQLFAAWMQDAEAAEPNDPNAMTLATATPDGRPSARIVLLKSWDEAGFVFYTNLESRKSLEIRANPDVSLLFHWKSLRRQIRIEGRCRAVSDDEADAYFDSRPRISRLGAWASDQSRPLGERAELERRLAEVTARYGDGPIPRPPHWSGWHVMPDSIEFWQDRDFRLHDRAVFTRTGDAWSATRLFP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.