PharMolix/UniProtQA huggingface dataset:
Protein: RPOC_CLOB1
Sequence: MFELNNFDALQIGLASPEKIREWSRGEVKKPETINYRTLKPERDGLFCERIFGPMKDWECHCGKYKRIRYKGIVCDRCGVEVTKAKVRRERMGHIELAAPVSHIWYFKGIPSRMGLILDMSPRALEKVLYFASYVVLDPKETPLLKKQLLNEKEYRESIDKYGDDSFVAAMGAEAVKTLLDEIDLEQSSIELKEELKTSTGQKKIRIIRRLEVVESFRKSGNRPDWMVIDVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKKLLDLGAPDIIVRNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKMYQCGLPKEMALELFKPFVMKKLVQNGLAHNIKSAKRMVERVQPQVWDVLEEVISDHPVLLNRAPTLHRLGIQAFQPVLVEGRAIKLHPLVCTAYNADFDGDQMAVHVPLSVEAQAEARFLMLAAHNILKPSDGKPVSVPTQDMVLGSYYLTMDKDGVKGEGKVFSCPEEVLMAYQCKAVDIHAKIKVRLKKVIDGETIEGIIETTPGKIIFNESIPQDLGYIDRTVPENKLKLEVDFLVSKKTLGGIINRCYMKHGATKTSIMLDKIKAKGYHYSTIGAITISTSDMVVPEAKRELLQNTEKQVEKIQKMYRRGFISEEERYEKVIDLWTKTTEDVANALMASLDSFNPIYMMADSGARGSKSQIKQLAGMRGLMANPSGKIIELPIKASFREGLDVLEYFISTHGARKGNADTALKTADSGYLTRRLVDVSQDVIVRQEDCGTEEGYEVSEIKEGNEVIEPLVERLSGRYPSEDIINPTTGEVIVKRNTYMNEDIAKKVSDAGIKKVKIRSVFTCKSKHGVCARCYGMNMATSQKIHIGEAVGIVAAQSIGEPGTQLTMRTFHTGGVAGADITQGLPRVEELFEARKPKGLAIVSEVSGTVKMEETKKKRTIIVVTDDGEEVSYDIPFGSRIKVKNGDIISAGDEITEGSINPHDILRIKGVDGVKNYLLSEVQKVYRLQGVDINDKHLEVVIRQMTRKIKIEDSGDTELLPGTMIDVFDFEEANREILEKGGEPAVGRIALLGITKAALATDSFLSAASFQETTRVLTDAAIKGKIDPLLGLKENVIIGKLIPAGTGMTRYRSIQINTDDENIEEDSMDSIEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: SSR2_MOUSE
Sequence: MEMSSEQLNGSQVWVSSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWCVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
What is the function of this protein?
Receptor for somatostatin-14 and -28.  This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.  In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins.  Inhibits calcium entry by suppressing voltage-dependent calcium channels.  Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion.  Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B.  Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development.  Mediates negative regulation of insulin receptor signaling through PTPN6.  Inactivates SSTR3 receptor function following heterodimerization.
What are the official names of this protein?
Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R, SRIF-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm (By similarity).
Protein: Y2981_DICC1
Sequence: MGVFDPTLLILLALAALGIISQNMTVTLAILFLVAVRITPLNHYFPWVEKYGLSFGVLVLTIGVMAPIASGKISAGDVLSSFLHWKSLMAVAIGVAVSWLGGRGVVLMSNQPSVVAGLLVGTVMGVALFRGVPVGPLIAAGLLSLLIGKG
What are the official names of this protein?
UPF0756 membrane protein Dd1591_2981.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NQRF_COLMA
Sequence: GGSCGQCRVEVHSGGGDILPTEEGHINKREAKSGCRLACQVAVKQDMEIEVEDEIFGVQQWECEVISNDNKATFIKELKLQIPNGESVPFKAGGYIQIEAPAHHVKYSDFEIDEQYRGDWKHFGFFDVESKVDTDTLRAYSMANYPEEEGIIMLNVRIATPPPGRLHLPAGKMSSYIFSLKAGDKVTISGPFGEFFAKETDNEMVFIGGGAGMAPMRSHIFDQLKRLHSKRKMSFWYGARSKREMFYEDDYNGLAADNDNFQWHVALSDPQPEDNWDGLTGFIHNVLFEEYLKDHEAPEDCEY
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit F, Na(+)-NQR subunit F, Na(+)-translocating NQR subunit F, NQR complex subunit F, NQR-1 subunit F.
What is the protein family that this protein belongs to?
Belongs to the NqrF family.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: HRCA_CHLPM
Sequence: MGSRELSLRERQVLGIIIQSYVVTAAPVGSRYIARNYSLGLSDATIRNVMADLEDEGYIHQPHTSAGRIPTDLGYRYYVDLIMKVQRIDEDEKRRMETDYGQIAMEHPGTSRDVLLSAAKVLGCISRQLSVVLSPTLSDAVFERLDMVLLSSTRMMVILSIHSLFVKTIVMELPLEVSRKMIEEVSNVINERLAGLTLSEIRRSIAHRLAGSHGDGALKDLIVRSAGSLFDESPIFERLYISGTEYIVDQPEFKQPERVRELITMIEDKFSVARLVEKSGHMSEALRPSDMDVTISIGSENSTREAEDLTIVSTPYYAGNMVGRLGILGPKRMDYEHAVRVLNYMADSLTATLTDAN
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ILVC_VIBCH
Sequence: MANYFNTLNLREQLDQLGRCRFMAREEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVSYALRQAAIDEQRQSFKNAKNNGFNVGSYEQLIPTADLVINLTPDKQHTSVVNAVMPLMKQGAALGYSHGFNIVEEGMQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPQGEGWEIAKAWAAATGGHRAGCLASSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMVADGIDPGYAGKLLQFGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADWANDDKDLFGWRAETAETAFENYPTTDVKIAEQEYFDNGILMIAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYGNYLFANVAVPLLREKFMPKVGTDVIGKGLGVVSNQVDNATLIEVNSIIRNHPVEYIGEELRGYMKDMKRIAVGD
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: LHB1_RHOPA
Sequence: MADKTLTGLTVEESEELHKHVIDGTRIFGAIAIVAHFLAYVYSPWLH
What is the function of this protein?
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
What are the official names of this protein?
Light-harvesting protein B-800-850 beta chain A, Antenna pigment protein beta chain A, LH II-A beta.
What is the protein family that this protein belongs to?
Belongs to the antenna complex beta subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: RL5_GEODF
Sequence: MARLNELYNKELVPQLMKDFNYRNIMQVPKLEKIVINMGLGEAIQNVKILDSAVSEMALIAGQKPVITKAKKSIAGFKLRQGMPIGCAVTLRREKMYEFLDRLINVSLPRVRDFKGISGKGFDGKGNYSLGVKEQLIFPEIDYDKIDKIKGLNITIVTSAKNDEEGKALLKLMGMPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RIFK_ASPFU
Sequence: MRPDGPRDPVAGPDSGPEPPYPVRLSGPVIKGFGRGSKELGIPTANIPAEGLEEYPDLQVGVYYGVVALDPAKFQYQEGQGSTSTSSTGGAEAAVLPAVLSIGYNPFYKNKTKSIEIHIMPPLSSPSPTADGAGEVKFHKLPDFYGTQLKLLILGYIRPEYDYVSLEALIEDIRVDCEVARKSLQRPAYACYIDGDEKECSDVVREQRRWLVTF
What is the function of this protein?
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
What are the official names of this protein?
Riboflavin kinase, Flavin mononucleotide kinase 1.
What is the protein family that this protein belongs to?
Belongs to the flavokinase family.
Protein: RL14_METTH
Sequence: MKAIASKVTRALPVGARLQCVDNTGAREVEIISVRGYKGVRRRLAAAGVGDMVVVSVKKGTVDMRREVLNAVIVRQKKEYRRPDGLRVKFEDNAAVIVSPEGVLKGSEIRGPVAKEAADRWPSVGSAASIIV
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SAHH_MYCPA
Sequence: MTTTENALTPDVRNGIEFKVADLSLADYGRRDIELSEQEMPGLMSLRREYHDVQPLKGARISGSLHMTVQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPRGVPVFAWKGETLEEYWWAAEQALTWPPLADGTEAPANMILDDGGDATMLVLRGAQYEKAGVVPPDDEDDSAEHRVFLNLLRARFETDKTKWTKISESIKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGCRHSLIDGINRGTDVLIGGKNVLVCGYGDVGKGSVESLAGQGARVTVTEIDPINALQALMEGYNVKRVEDVIGEADIVITATGNKDIITLEHMKAMKDKAILGNIGHFDNEIQIARLEKSGAIKTNIRPQVDLWTFPDTGKSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGELTKLTKEQAEYIGVDVDGPYKADHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_NEIGO
Sequence: MKAYLDLMRHVLDNGTDKSDRTGTGTLSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGNLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAVVSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1638_DICDI
Sequence: MEPILIPSQHNRLVIPSEPNEEEFNYIADGYKGKLNIDSYDIISTIGSGSYGEVCIVREKSTKQVYAMKKIYYTEVSDTELVKKRALRERDAMVICNNKNNKRAPKLYCSFIDDNEGVFYYVMEFIAGGDFNSYCYKRLVDGKKFTEEEIKFYIAELVLCLEAFHSYGLLHRDVKPENLMINKDGHLVLGDFGSSKLANNSGGGGGNFGNTLTVPMSTSYSTSPSSSISSSLLGGSGGFTPSHWNGMAGSAGSSFGSSSLGRSFDNTPPNFNSFLRNPHSSYTSYIGTPQYMAVEVVQGVNYSKLCDFWSLGAILFELVTGQALFVESPDTTEQKIRENIGNWRGLLNTAVQKNQPMSKQAESLIRECIAPERKRPDASTIKKHPFFEGINWEEMANFNVEPPFKPTLSSDDDISYFTN
What are the official names of this protein?
Probable serine/threonine-protein kinase DDB_G0290859.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Protein: PNTA_HAEIN
Sequence: MLIGVPRELLENESRVAATPKTVQQILKLGFDVIVEHDAGFKASFEDQAFLEAGAKIGTSAEIWQSDIIFKVNAPTDEEIAQMKEGAALVSFIWRMQNPELMKKLTAKKINVLAMDAVPRISRAQALDALSSMANISGYRAVIEAAHEFGSFFTGQITAAGKVPPAKVLVIGAGVAGLAAIGAANSLGAIVRAFDSRPEVKEQVQSMGASFLEIDFKEEGGSGDGYAKVMSEEFNRRAMELYAEQAKEVDIIITTAAIPGKPAPRLITKEMVDSMKPGSVIVDLAAATGGNCEYTQAGKVVTTENQVKVIGYTDFPSRLPTQSSQLYGTNLVNLLKLLCKEKDGNINIDFEDVVLRGVTVVRDGEEIPPAQIQVSAQPKQETKAAPVAEKKESKPTDPRVKYGVMAGVGVLFLWLASVAPAAFLSHFTVFVLACVVGYYVVWNVSHALHTPLMAVTNAISGIIIVGALLQIRQPTGNLFIDALAFVAILVASINIFGGFRVTQRMLAMFRKG
What is the function of this protein?
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.
What are the official names of this protein?
NAD(P) transhydrogenase subunit alpha, Nicotinamide nucleotide transhydrogenase subunit alpha, Pyridine nucleotide transhydrogenase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KATG_PARDP
Sequence: MDGNDIRSTGKCPVMHGGNTAMGSSVTAWWPNALNLDILHQHDSKTNPLGQDFNYSEELKKLDVEALKADLRALMTDSQDWWPADWGSYVGMFARTAWHMAGSYRTSDGRGGANTGNQRFAPLNSWPDNVNTDKGRRLLWPIKKKYGNKISWADLIVLAGTVAYEAAGLKTYGFAFGREDIWHPEKDTYWGEEKEWLAPSDSRYGDVTKAETLANPLAAVQMGLIYVNPEGVNGKSDPQATAYQMRETFARMGMNDEETVALTAGGHTVGKCHGNGNVTDLSPDPEAAGPEFQGLGWMNTKGRGIGRNTMVSGLEGAWTTHPTQWDNGFFEMLFKHEWTLTHSPAGASQWEPITIAEEDKPADVEDPSIRHMPMMTDADMALKVDPIYREISLRFMNDFEAFSDAFARAWFKLTHRDMGPKARYLGPDVPAEDLVWQDPIPAGRSDYDVAAVKARIAASGLSASDLVATAWDSARTYRGSDHRGGANGARIRLAPQKDWEGNEPQRLARVLSVLEPIAAETGASLADVIVLGGNLGVEQAAKAAGFDIEVPFAPGRGDSTAEQTDAASFDVLEPLADGFRNWQKQDYVVSPEEMLLDRAQLMGLTAPEMTTLIGGLRVIGTNHGGTKHGVFTQRKGALTNDFFVTLTDMANNWVPVGNNLYEIRDRKTGATRYTATRVDLVFGSNSILRAYAEVYAQDDNAGKFVRDFVAAWTKVMNADRFDLAA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: ASSY_STAS1
Sequence: MKEKIVLAYSGGLDTSVAVKWLLDKGYDVVACCLDVGEGKDLELVHQKALDMGAIECHIIDATEEFSQDYVSYAIKGNLMYEGTYPLVSALSRPLISKKLVEIASKTNSVGIAHGCTGKGNDQVRFEVAIKALDPELKVFAPVREWAWSREEEIDYAIKHNIPVPIQHDSPYSIDQNLWGRSNECGILEDPYATPPKDAYDLTNELEDAPDEAEEIVLSFEKGIPVSLDGTAYKLSELILELNKLAGKHGVGRIDHVENRLVGIKSREVYETPAAEVIMNAHKALETITLTKDVAHFKPVIEKQFSEQIYNGLWFSPLTDSLKIFVDSTQAHVTGDVRLKLYKGNAIVNGRQSPYTLYNEKLATYTKEDAFNQESAVGFIDIFGLPTKVNSMLHGGYKDEQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_BORHD
Sequence: MEEYKALLDEKMDRVLLSLDSEYKSLRTGRISSALFDKVLVDYYGEKTPLTRVANISIPEARLIVIQPWDKSLLSKIEQAILSSDLSMNPSSDGSVLRIKVPVLTVERRKEIVKQAKKIAEEYKVAARNVRQELNNKAKKQEKDSQITEDDLRRILDDIQRDTNSYIKKIDEIFDLKTKEIMEF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF20_PORPU
Sequence: MIRTKLSIFFSYFVQNLSSRLYYSLNELTAGLISLLLGFFISTGLSTIPGQTGDWGIIAASLIVAAIELVSKIVYSNKKKYGVRINLLNNLKIGITYGLFVDAFKLGS
What are the official names of this protein?
Uncharacterized protein ycf20.
What is the protein family that this protein belongs to?
Belongs to the ycf20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IFNE_MOUSE
Sequence: MVHRQLPETVLLLLVSSTIFSLEPKRIPFQLWMNRESLQLLKPLPSSSVQQCLAHRKNFLLPQQPVSPHQYQEGQVLAVVHEILQQIFTLLQTHGTMGIWEENHIEKVLAALHRQLEYVESLGGLNAAQKSGGSSAQNLRLQIKAYFRRIHDYLENQRYSSCAWIIVQTEIHRCMFFVFRFTTWLSRQDPDP
What is the function of this protein?
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract.  Directly mediates protection against viral, including HSV-2, and bacterial, including Chlamydia muridarum, genital infections.
What are the official names of this protein?
Interferon epsilon, IFN-epsilon, Interferon epsilon-1, Interferon tau-1.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: LEXA_CLOBH
Sequence: MNKSRIDKQNEVYNFIKLQIKEKGYPPSVREICKAVGLSSTSSVHFHLKRLEKEGLIKRDSSKTRAIEIVDPTSKKEVINVPIVGTITAGNPILAIENIEDVFPLPIDYVKNTKDLFMLKVSGESMIEAGILNGDLAIIEKTDSANNGDIVVALIDNEATLKRFFKESSYIRLQPENKSMKPIILENCKVLGRLVGIYRKY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RS25_RAT
Sequence: MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S25.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS25 family.
Protein: CGHA_CHAGB
Sequence: MSGTPRTMPPLMMDWAEQPNGRAKPRGMVISRVPYLPWYLLGAVRVGGVSNARPNSRPYSAEQADFGRISQTALCRYRSMPVRNPTPYGVGTQVWRAVVLHHLPLTAAMAAAPFISLLQGDQFLADTPIPGSAVIPNSGNLFPKWADKLSPTAVETWLFDAMAEDGSAAFTVSFFRDGSQAPASFRAAINAAWSDGTVWSQHLVVPVSVVTSDGPDVGHGHVAGVWRTEEPQSNDTTRTTASFDVAADLSTTTVVFDAPGRITGSLTHRSLGYPTLPQSDREAEVAPGAYWFRPIAMANATVDLTFHIDDPTNPDKKTEKRMVLGPEQGAFGGMDRSWLPMVWGKEATDALFVRAQAGPYVMAVMRLVSKPHKYYQNTVNAALYRDGKIVSNALRSLPPDRRDTAATADAVRTEKLYDGDGLVAKYRDKNVGYRLEFRSAGPEREKWSFDLRHHQAWWAKPTSRPGPDGTGNSGFVVEVTGGLVGSEESVHGWGMTGEVELSD
What is the function of this protein?
Diels-Alderase; part of the gene cluster that mediates the biosynthesis of the tetramic acid Sch210972, a potential anti-HIV fungal natural product that contains a decalin core (PubMed:26360642).  The PKS module of cghG together with the enoylreductase cghC catalyze the formation of the polyketide unit which is then conjugated to 4-hydroxyl-4-methyl glutamate (HMG) by the condensation domain of the cghG NRPS module (PubMed:26360642).  One unique structural feature of Sch210972 is the tetramic acid motif proposed to be derived from the non-proteinogenic amino acid HMG, by a Dieckmann-type condensation catalyzed by the reductase domain of cghG (PubMed:26360642).  The aldolase cghB catalyzes the aldol condensation of 2 molecules of pyruvic acid to yield the intermediate 4-hydroxyl-4-methyl-2-oxoglutarate (HMOG), which can then be stereoselectively transaminated by an unidentified enzyme to form HMG (PubMed:26360642).  The Diels-Alderase cghA then uses the Dieckmann product released by cghG as substrate and catalyzes the Diels-Alder cycloaddition to form the decalin ring of Sch210972 (PubMed:26360642).  CghA also suppresses the nonenzymatic formation of the alternative stereoisomer (PubMed:26360642).
What are the official names of this protein?
Diels-Alderase cghA, Sch210972 biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the Diels-Alderase family.
Protein: NTPTH_NATTJ
Sequence: MTESNILLTGKPGIGKTTVIKRTVELLSCSSTGFYTREIKRGDPRVGFEIISLQTGERLPLAHTDFTTAEDRVGKYGVKAENLLGFLKEINEAMTSNKPQCLVIDEIGKMEFFTPGFHETVDKAFQSSYPLLATIMKKSHKFCDYLKNRGDTDVIEVTENNRDDLPEKLAKRIEEQL
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: NUOB_PARP8
Sequence: MSIEGVLKEGFVTTTADKLINWTRTGSLWPMTFGLACCAVEMMHAGAARYDLDRFGVVFRPSPRQSDVMIVAGTLCNKMAPALRKVYDQMAEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGVIQLQAKIRRTNTIARQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYFA_THEGJ
Sequence: MELSYQEKLTLIKLNELKRAKFEELVKATGLEQVAVMRAVLGLQAKGLAKLHERSEKVVKLTETGKKYAEIGLPEWRALKLLRERGKVTLDDLREVLSDDELKPIVGLLRKEGWASVRKEDGKLILEITEKGLEAEERPIDRALKLLAEKNVVPVKEIEKLIPVKELKRRKIGEEETVTERTVEITPAGEELAPKVELKREVSVLTPELIKSGKWREVEFRRFDIKAPVRRIYPGKKQPYRAFLDKIRRRLIEMGFIEMTVDSLIETQFWNFDALFQPQNHPAREWTDTYQLKYPKSGFLPEEELVERVKTAHERGLAGSRGWGYVWSPERAMLLMPRAHGTALSGRQLAKGVEIPGKYFTIQRVFRPDVLDRTHLIEFNQIDGFVVGEELNFRHLLGILKRFAVEIAGAKKVKFLPDYYPFTEPSVQMSAYHPELGWVEFGGAGIFREEMTKALGIEVPVIAWGIGIDRLAMFKLGIDDIRYLFSYDLRWLREAKLVW
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNO1_DROME
Sequence: MEAENIRADAFEPAKRATKRGASGGGQQDVEMQVDEATGIEGQVLGSSRASAPPKAKRARSELRKVSVPPHRYSSLKEHWMKIFTPVVEHMKLQIRFNMKARQVELRVGPETPDIANLQRGADFVRAFLCGFEVDDALALLRLEDLFVESFEIKDVKTLRGDHQSRAIGRLAGKGGRTKFTIENVTKTRIVLADSKIHILGSYQNIQLARRAVCNLILGSPPSKVYGNLRAVASRLSERM
What are the official names of this protein?
RNA-binding protein pno1.
What is the protein family that this protein belongs to?
Belongs to the PNO1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RBFA_ALKEH
Sequence: MPRDFPRTRRVGEQIQRELAELIRDELRDPRLGMVTVSEVTVSRDLAHAKVFVTALGGSDEDNAKTVEVLTRAAGYLRKLLGQRLRIRQVPALHFQHDTAFDRGDRLSRLIDEAVEEDRQQHDDDKPDNG
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.