PharMolix/UniProtQA huggingface dataset:
Protein: S27A1_BOVIN
Sequence: MRAPGAGSASVASLVLLWLLGLPWTWSTAAALGVYVGGGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRARHTIPQIFQAVVQRQPERLALVDAGSGACWTFAQLDAYSNAVANLFRRLGFAPGDVVAIFMEGRPEFVGLWLGLAKAGVEAALLNVNLRREPLAFCLGTSGAKALVFGGELAAAVAEMSGELGKSLVKFCSGDVGPDGVFPDTQLLDPLLKETSTAPLAQPPGKGMDDRLFYIYTSGTTGLPKAAIIVHSRYYRIAAFGHYSYSMQAADVLYDCLPLYHSAGNIMGVGQCLIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLKQPVREAEGRHRVRLAVGNGLRPSIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSRGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQTGEPGLLVGQINQQDPLRRFDGYISESATSKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKACMAAIADPHGRLSPNALYEELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQHEGFDPRQTSDRLFFLDLKQGHYLPLDQGVYTRICSGAFAL
What is the function of this protein?
Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane.  Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake.  May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation.  Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis.  May be involved in regulation of cholesterol metabolism.  Probably involved in fatty acid transport across the blood barrier (By similarity).
What are the official names of this protein?
Long-chain fatty acid transport protein 1, Arachidonate--CoA ligase, Fatty acid transport protein 1, FATP-1, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 1, Very long-chain acyl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm. Note=Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes.
Protein: TIG_MYCS5
Sequence: MSDFKFTNTETELVVSLFVSKEQVDKEYQKLETEALKKIKVNGYRAGKAPKEALRARLNSKDLLDRVLQNLSKENLNEVYKQLMERKEPVTFAYTIDLKEKENGFTFDYKFAKVPTVSDLDVKSAKTELKLEKVTDKDVLESIETRLNEGRSRVKVEDEAKKGDEVLFDFKGYIDGEAFEGGEAEDYSLVLGSAQFIAGFEEQLLGKKAGWKGEIKATFPSTYYVKNYRDKEATFEINLKEVRRVNSLKLDSKEFKDSPLGSEEYLGQYKVFVKKDLVVSRFIQSQRDFLDELVKELSQSVKFHISDLLLKEKIAQLDKQFNDQLKQYKVKRKEYLEVIKATEEDIQVELKTSAVNEYKLSYIYQELLKEFKKEFTEEEKKQYQEVFDALKFTSPSNDLLDQLAVLEGLLEKTSRTKELKAWNDYKVYLVEELKKLDKEIQSMQEKQTQEPAEEKVETKEEK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ENO_CHLMU
Sequence: MFDVVISDIEAREILDSRGYPTLYVKVITNTGIFGEACVPSGASTGIKEALELRDQDPKRYQGKGVLQAVANVEKVLLPALQGFSVFDQITADAIMIDADGTSNKEKLGANAILGVSLALAKAAAATLERPLYRYLGGAFSHVLPCPMMNLINGGMHATNGLQFQEFMIRPISAPSLTEAVRMGAEVFHTLKKILQNRQLSTGVGDEGGFAPQLASNSEALDLLLAAIEKAGFIPGEDISLALDCAASSFYNTQDKTYDGKSAADQVAVLTELCDRYPIDSIEDGLAEEDFEGWKLLSETLGDRIQLVGDDLFVTNSALIAEGIAQGLANAVLIKPNQIGTLTETAEAIRLATTQGYATILSHRSGETEDTTIADLAVAFNTGQIKTGSLSRSERIAKYNRLIAIEEEIGPEAVFQDSNPFSKA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: MINC_BACP2
Sequence: MKTQKQQYVTIKGTKNGLTLQLNDDCSFDDLLSGLRELLLLEQYTDGREGHKVNVHIKLGFRYLTEDQEMRLTEAVSENEHLVIHSIESDVMSTEEAKRLKAEAEITSVAKIVRSGQVLYVEGDLLLIGDVNPGGTIRAGGNIFVLGALKGVAHAGCNGNKQAVIAASRMIPTQLRIAQVFNRAPDQKEDGNEMECAYLDIDGNMIIERLQQLAHIRPNLTRLEGGM
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: PVK3_PRIVA
Sequence: GSSGMIPFPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-3, PriVa-PVK-3.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACKA_BACC1
Sequence: MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGLEDSIFTITVDGEKQKEITNIPDHAVAVNMLLKKLTENGIVKSLDEIGGIGHRVVHGGEKFADSVLITDEVLADIEELSDLAPLHNPANVVGIKAFQEVLPNVPAVAVFDTAFHQTMPESAFLYSLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLESLSLLSCHLGNGASIAAVEGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPYIMEKTGQTVEEVVNVLNKKSGMLGLTGYSSDLRDIIAKEEEGDHRAKVALDVFVSRIHKYIGSYTARMKGVDAIIFTAGVGENSAIIRERVLEGLEYMGVYFDAKRNNVFGEEAFINFPHSPVKIIVIPTDEEVMIARDVLRLGNIG
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_HALS3
Sequence: MLVTLEGLDGSGKTTVWESLRASHDDGVTFTAEPTDSQYGQAVRRSESAADADPIAELFLFTADHADHLSRVVSPALDRGDVVISDRYSDSRYAYQGATLADTVPRAMEYVRGIHQPWTRPPDVTLYFDVDPDTGAARSGATNKFETAAFLADVRANYEQLIDYTPERFVRIDATQSPEAVIADAEAALADALPDDAWA
What are the official names of this protein?
Probable thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: ENO_GEOSM
Sequence: MSQITDVYAREILDSRGNPTLEVEVFLDSGVMGRAAVPSGASTGEREALELRDGDKGRYLGKGVEQAVSNVNDIIADEITGMDATDQVGIDKKMLELDGTEFKSRLGANAILGVSLAVAKAAAEEVGVPLYQYIGGCNAKELPLPMMNIINGGAHADNNVDIQEFMIMPAGAANFKEALRMGAEIFHALKSVLKGKGYNTAVGDEGGFAPNLKSNEEALEVIMEAIVKAGYKPGEEVLLALDVASSELFENGVYTLENEAESKKTADQLVDFYENLVNKYPIVSIEDGMAENDWDGWKKLTDRLGKRIQIVGDDLFVTNPSILKEGIKKGIANSILIKLNQIGTLTETLDAIEMAKRAGYTCVISHRSGETEDTTLADLAVAVNAGQIKTGSLCRTDRVCKYNQLLRIEDELDDVAQFRGHEVFYNIKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: FABA_PSEPW
Sequence: MTKQHAFTREDLLRCSRGELFGPGNAQLPAPNMLMVDRITHISEEGGKYGKGELVAELDITPDLWFFACHFEGDPVMPGCLGLDAMWQLVGFFLGWQGLPGRGRALGSGEVKFFGQVLPTAKKVTYNIHIKRVLKGKLNMAIADGSVSVDGREIYTAEALRVGVFTSTDNF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC18_CAEEL
Sequence: MSATRRLQKELGDLKNCGVKAYENVECEETNLLKWTVLLIPDKEPYNKGAFKVGITFPVDYPFKPPKVAFETKIYHPNVDEEGKFCLPIVTAENWKPATKTEQVMMALLSLINEPEPSHPIRADVAEEFQKDHKKFMKTAEEHTRKHAEKRPE
What is the function of this protein?
Ubiquitin-conjugating enzyme E2 (PubMed:19553937).  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19553937).  Required for diet restriction-mediated lifespan extension, probably acting as part of a complex with ubiquitin-protein ligase wwp-1 (PubMed:19553937).  Acts redundantly with lin-35/Rb in the regulation of pharyngeal morphogenesis during embryonic development by negatively regulating the expression of proteins such as sup-35 (PubMed:12783801, PubMed:19521497).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 ubc-18.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: LPXH_SHEHH
Sequence: MRTLFVGDLHLSTDRPDITQAFLRFLDTQLHDTDALYILGDLFEVWVGDDIAEPFAEQLAKAIYQASQKLPIFFIHGNRDFLISNAFAKRSGMTLLPEIYTVDLYGIPTVILHGDSLCTLDKPYQRFRKFRNLGWAKWLYAHLPKSKRLDIAVKLRSKSQSSNQQKSYSIMDVEPDAVLELLNATKTEQMIHGHTHRPAIHQLANGRRRIVVGDWYEQGSMLSVSQDKIELIELPFGK
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NANE_STAAR
Sequence: MLPHGLIVSCQALPDEPLHSSFIMSKMALAAYEGGAVGIRANTKEDILAIKETVDLPVIGIVKRDYDHSDVFITATSKEVDELIESQCEVIALDATLQQRPKETLDELVSYIRTHAPNVEIMADIATVEEAKNAARLGFDYIGTTLHGYTSYTQGQLLYQNDFQFLKDVLQSVDAKVIAEGNVITPDMYKRVMDLGVHCSVVGGAITRPKEITKRFVQIMED
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: URE3_SACEN
Sequence: MHLAPHERDKLLVHLAARLARERMDRGLKLNHPEAVALITDHVVEGARDGRGVSELMKSGREVLTAEQVLDGVADMVREVQVEATFPDGTKLVTVHDPIN
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAB_OLIPU
Sequence: MALRFPRFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQNIFASHFGQLAIIFLWTSGNLFHVAWQGNFETWVQDPLHVRPIAHAIWDPHFGQPAVEAFTRGGALGPVNIAYSGVYQWWYTIGLRTNEDLYTGALFLLFLSALSLIGGWLHLQPKWKPRVSWFKNAESRLNHHLSGLFGVSSLAWTGHLVHVAIPASRGESVRWNNFLNVLPHPQGLGPLFTGQWNLYAQNPDSSSHLFGTSQGSGTAILTLLGGFHPQTQSLWLTDMAHHHLAIAILFLIAGHMYRTNFGIGHSIKDLLEAHIPPGGRLGRGHKGLYDTINNSIHFQLGLALASLGVITSLVAQHMYSLPAYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNEDNVLARMLDHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKTSYGFDVLLSSTSGPAFNAGRSIWLPGWLNAINENSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVSQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWKDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DNAK_MYCAP
Sequence: MAKEVIIGIDLGTTNSVVSIVDNGSPVVLENLNGKRTTPSVVSFKDGEIIVGDNAKNQIETNPDTVASIKRLMGTSKTVHVNNKDYKPEEISAMILEHLKKYAEEKIGHKVEKAVITVPAYFDNAQREATKIAGKIAGLEVLRIINEPTAAALAFGLDKVKKEQKILVFDLGGGTFDVSILELAEGTFEVLSTAGDNRLGGDDWDNEIVKWLIDLIKKDYKTDVTNNKMAMARLKAAAEKAKIDLSSSQQATIMLPFLVMQQGSEPISVEATLRRSQFEEMTSHLVERCRKPIETALADAKIKISDLDDVILVGGSTRIPAVQQLVESILNKKANRSVNPDEVVAMGAAIQGAVLAGEIDDVLLVDVTPLTLGIETAGGIATPLIPRNTRIPITKSEVFTTFEDNQSEVTIRIVQGERPLASENKLLGQFNLGGIRVAPRGVPQIEVSFKIDANGITTVLAKDKDTNKEQSITIKNSSKLSESEIEEMIKDAEKNREADAKRAEEISTIIQAENLVNSLEKEMNDGNIVIPEEEKAKIADYIKEVKELINNKDVEQLKKKIDELNAAYNMAKSAAASSNKDDSLNNNSSSNNDEETFE
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MINE_BRASO
Sequence: MSVLRLFTGRAASAPVARERLQILLAHERSLRGQPDLLMQLREEILAVVSRHVLLDPDKVIVRMDRGKHVSTLEVDIELPNGADRAFASAG
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: MURB_RHORT
Sequence: MIALRAPTPLIDRLPAVRGRLSADVALAPVTWFRVGGPAEAMFKPADAQDLADFLAGRPRDVAVRVIGVASNLLVRDGGVPGVVIRLGRAFTGVEVVGETLVCGASALDATVAKVAEAAGLAGLEFLSGIPGTLGGALRMNAGAHLREMADIVVLATAVDGLGQSHTLTPAQMGFSYRACALPEDWIFTGCVLAGRPDERGAIAARMEALRQAREASQPLRARTGGSTFANPDPDLSGGRRAWELIDAAGCRGLRLGGAQVSEKHCNFLINTGEATAADLEALGETVRRRVMDTSGVALRWEIKRIGIGLDGLSAGENG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF5A1_CAEEL
Sequence: MSEDHHDEEQFDSAESGAAATFPKQCSALRKNEHVMIRGRPCKIVEMSTSKTGKHGHAKVHMVAIDIFTTKKLEDICPSTHNMDVPVVKRREYILMSIEDGFCSLMDPESCELKDDLKMPEGDLGNTIREALEKDEGSVLVQVVAACGEEAILGYKISTKE
What is the function of this protein?
mRNA-binding protein involved in translation elongation.  Has an important function at the level of mRNA turnover, probably acting downstream of decapping.  Critical for the efficient synthesis of peptide bonds between consecutive proline residues.  Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity).  Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity.  Functions as a regulator of apoptosis (By similarity).  Required for mitotic germ cell proliferation, gametogenesis after entry into meiosis, and localization of the P granule component pgl-1 on P granules.
What are the official names of this protein?
Eukaryotic translation initiation factor 5A-1, eIF-5A-1, Initiation factor five protein 1.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_CHLTE
Sequence: MRTVVQQVREASVSIGGELHSSIGTGLLVLAGISRDDTADDLAWMSRKIPNLRIFEDEKGKMNRSLKDIGGALLVVSQFTLYADASRGNRPGFSESAPPELARVLFDRFVESIRHEAGCPVETGVFGADMQVSLVNDGPVTIILESPKKP
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_BORPD
Sequence: MRASTYHLNTLKEAPAEAEVASHRLMTRAGMIRKLAGGIYTYMPLGLKVIRKIEAIVRAEMDAAGAIELLMPVVQPAELWQESGRWEQYGAELLRIKDRHQRDFVLQPTSEEVITDIARNEIHSYRQLPLNFYHIQTKFRDERRPRFGLMRGREFTMKDAYSFDRDEAGAQQSYDKMYDAYMRIFERLGLQFRAVAADTGSIGGSRSHEFQVIADTGEDLLVYNPDSQYAANIELAEAPALLAERAAATQPLEAVPTPGAAKCADVAKLLGLPLERTLKSIVLATEPEPGKVQVWLLLLRGDHELNEIKAGKLPGLAGFRFATEDEIVAHFGCKPGYLGPIGTALPVRVVADRTVANMADFVCGANREDFHYQGANWGRDLPEPELVADLRNVVEGDPAPDGAGRLAIQRGIEVGHVFFLGTKYSEALKATFLDETGKPALLQMGCYGIGITRIAGAAIEQNHDERGIIWPRAIAPFEVVICPVGWGKNETVRNESVKLYDALRARGVDVILDDRDARPGVMFAEWELIGVPLRVTVGERGLNDGVVELQARRESTAAKIPAGSALEQVLAKLETL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3032_CUPTR
Sequence: MMRSFKSTQEPSRQARGAQAEDRALAHLRRQGLEPVVRNYRCKGGEIDLVMRAPDGTLVFVEVRQRSGRGFGGAAASITPAKQRRVVLAARHYLATLARVPPCRFDVVALEPDRLEWLQHAFDADAAGAGS
What are the official names of this protein?
UPF0102 protein RALTA_A3032.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: IL2_BOVIN
Sequence: MYKIQLLSCIALTLALVANGAPTSSSTGNTMKEVKSLLLDLQLLLEKVKNPENLKLSRMHTFDFYVPKVNATELKHLKCLLEELKLLEEVLNLAPSKNLNPREIKDSMDNIKRIVLELQGSETRFTCEYDDATVNAVEFLNKWITFCQSIYSTMT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL25_ALIFM
Sequence: MKFEAVVRTEQGKGASRRLRHAGQFPAIVYGGTEAPVSIALDHDAVINQMDKPAFYEAIELVIDGAVVKVKPQDVQRHAFKPKVEHMDFIRI
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: LDH_THEPX
Sequence: MNKISIIGSGFVGATTAYTLALSGIAKTIVLIDINKDKAEGDALDISHGVPFISPVELYAGDYSDVSGSDIIIITAGAAQKPGETRLDLVKRNTMIFKDIVAKLIKVNDTAIYLIVTNPVDILTYVTYKISGLPYGRVLGSGTVLDSARFRYLLSKHCNIDPRNIHGYIIGEHGDSELAAWSITNIAGIPIDNYCNLCGKACEKDFREEIFNNVVRAAYTIIEKKGATYYAVALAVRRIVEAIFRDENSILTVSSPLTGQYGVTNVALSLPSVVGRNGIVNILELPLSQEEIAAFRRSAEVIKSVIQELDI
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF6_PYRFU
Sequence: MHIEKLDFENSPYLGVFGIATDKVVLIREGLQEKKLEVIREVLKVPVVEASLMKSRIIGVLGAGNSNAIIVPWYVWDSELEKIKNAFREYGIDTEVVPFQTKYTALGNLILTNDKGALVSSKFSREEAKKIGDILGVEVERGVIAGIVAVGSAGVVTNKGGLVHPEATDEELEWLSDLFKVDVYVGTANMGVPYVGSCMLANSYGVVVGHLTTGPEIVKIEEALGFI
What is the function of this protein?
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
What are the official names of this protein?
Translation initiation factor 6, aIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.