PharMolix/UniProtQA huggingface dataset:
Protein: AROC_LEGPA
Sequence: MSGNTFGALFTVTTFGESHGPAIGCVVDGCPPGMSLTEADIQPFLDKRKPGQSKYTTQRREEDKVQILSGVFDGKTTGAPIALLIQNTDQRSRDYEDIKNLFRPGHADFTYHYKYGHRDYRGGGRSSARETAARVAAGAIARLYLKRYLNLDIIGYLQQMGDLKLQFENENEINKNPFFCPNNKQTQELADYIDRLRRQGDSVGARVKILARGVPTGLGDPVFDKLDATLAYAMMSINAVKGVEIGAGFNAVEQLGSYHRDQMTAKGFLSNHAGGILGGIATGQPIEVSIALKPTSSITTPGQTINTEGEEVTVVTKGRHDPCVGIRAVPIAEAMMALVLMDHYLRHKAQCK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: CLD1_RAT
Sequence: MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV
What is the function of this protein?
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.  While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules.  Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability.  CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin.  Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (By similarity).
What are the official names of this protein?
Claudin-1.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Protein: FBX42_PONAB
Sequence: MASSSDSEDDSFMAVDQEETVLEGTMEQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFVKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAAEGYDLKIGLSLAPRRGSLPDQKDLRLGSVDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGRHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR
What is the function of this protein?
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.  Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity).
What are the official names of this protein?
F-box only protein 42.
Protein: RXLRF_PHYIT
Sequence: MRLSFILAATLTGLLACATASDSEKIIRISNEQVLSDRQLLDTVVNDNEKRFLRAYNDAEDDSEDPKNVKNTVDAKPADESEDSELSEEERFSLIQMSNQPRYYWWFQHEMTPRDVRRALGLRAGSIKLVKRSIYRGYVKYYNKHCSYYENRKKDFCKAKEY
What is the function of this protein?
Effector that enhances P. infestans colonization of Nicotiana benthamiana leaves.
What are the official names of this protein?
RxLR effector protein PITG_06094.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus, host nucleolus. Host nucleus.
Protein: HSPQ_SALEP
Sequence: MIASKFGIGQQVRHSLLGYLGVVVDIDPEYSLDEPSPDELAVNDELRAAPWYHVVMEDDDGQPVHTYLAEAQLRSEMRDEHPEQPSMDELARTIRKQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGP1_CAEEL
Sequence: MDRIQENQKKATNLCELYADGNDDDSEKEQQDRGLDAQFLLRSTPEDVEKYMIHVRKQLMEGEGECLVELGAPINSNSKNPKSGLSEEDLDKAADAQLKILEKIPAVGTKVIRRKQTGGGSLFTEVWIIRDPPTEKDFIEARVAVVGNVDAGKSTLLGVLTHSALDDGRGAARTKLFRHKHEFESGRTSSVGNDILGFDVHGNIVNKPDPHNHNLDWVQIGSDCAKLVTFIDLAGHEKYLKTTIFGMTGHMPDYTMLMIGANMGIIGTTKEHLSLALSLHVPVYLVVTKIDMCPANILEETMKNITRLVRSAKKLPILVRNMDDVVHAAVNFPSKKVCPIFQVSNVEGTNLPLLRQFLNIVPLRRQLNENDPAHFQIDDIYWVDGVGTIASGTLLSGTIRLNDILLLGPTSNGDFMPIPIKSIHRKRMPVGIVKCGQSASFALKKIPKKDVRKGMVLVDPKVKPVASMVFEAEILVLHHPTTIKPNYQAMLHIGSVRQTATLVSMGKEVLRTGDRDKVQFKFIRQPEYIRPGTKMVFREGRTKAVGTVSSVVPQESLAQQRAKQKDGRQKQYGKKSMGPKPPNGKPKEKIEKKLDALSIEQLTSAASTSTSST
What are the official names of this protein?
GTP-binding protein cgp-1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.
Protein: DXS_CHLTB
Sequence: MTYSLLPHIHSPQDLHALSLDKLPVLCDEIRNKIIESLSLTGGHLASNLGGVELTVALHYVFSSPDDQFIFDVGHQSYVHKLLTGRNTEAFSNIRHDNGLSGFTTPQESNHDIFFSGHAGNALSLALGLAKGSSNSSSHILPILGDAAFSCGLTLEALNNIPADLSKFIIVLNDNQMSISENVGNIPQGISQWIYPQKISKLSQKIHSWIQNLPSFLHKKKTLSHKVDIALKSLSHPLFEQFGLHYVGPIDGHNVKKLVQALQMIKDQPQPILFHVCTVKGNGLTEAERDPIRYHGVKAHFQNTSLKKTSGNVELQTPISFPQHAGNILCRLGKKYPQLQVVTPAMSLGSCLEDFRKQFPDRFTDVGIAEGHAVTFSAGIARSGTPVCCSIYSTFLHRAMDNVFHDVCMQELPVIFAIDRAGLAFHDGRSHHGIYDLGFLCSMPNMVICQPRNALVLERLFFSSLLWKSPCAIRYPNIPANEKASNSSFPFSPILPGEAEILCQGDDLLLIALGHMCNTALTVKEHLLDYGISTTVVDPIFIKPLDRKLLQSLLTHHSKVIILEEHSIHGGLGSEFLLFLNQHNIKADVLSLGVPDMFIPHGNPETILNLIGLTSDHITQRILSHFKFSTPIPIERFFKA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: SKI3_HUMAN
Sequence: MSSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGLANLYEKYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYYQEKKHLEVARTWHKLIKTRQEQGAENEELHQLWRKLTQFLAESTEDQNNETQQLLFTAFENALGLSDKIPSEDHQVLYRHFIQSLSKFPHESARLKKACEGMINIYPTVQYPLEVLCLHLIESGNLTDEGQQYCCRLVEMDSKSGPGLIGLGIKALQDKKYEDAVRNLTEGLKESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALKIVDNLGASGNSLYQRNLCLHLKAEALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIEKALEYFTCALQHRADVSCLWKLAGDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKNELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQAQHLAETGSNMNDLKELLEKSLHCLKKAVRLDSNNHLYWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQAHEAFKMAQSLDPSYLMCWIGQALIAEAVGSYDTMDLFRHTTELNMHTEGALGYAYWVCTTLQDKSNRETELYQYNILQMNAIPAAQVILNKYVERIQNYAPAFTMLGYLNEHLQLKKEAANAYQRAILLLQTAEDQDTYNVAIRNYGRLLCSTGEYDKAIQAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYERALSIVESEQDKAHILTALAITEYKQGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQDATLSKAALNELLKHIKHKDSNYQRCLLTSAIYALQGRSVAVQKQISKAVHSNPGDPALWSLLSRVVAQYAQRNAKGGVVAGNVAHILDSNHGKKALLYTAVNQLAMGSSSAEDEKNTALKTIQKAALLSPGDPAIWAGLMAACHADDKLALVNNTQPKRIDLYLALLSAVSASIKDEKFFENYNQSLEKWSLSQAVTGLIDTGRISEAETLCTKNLKSNPDQPAVILLLRQVQCKPLLESQKPLPDAVLEELQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQRGSWSGKLSSLLRLALLALKVCMANISNDHWPSLVQEATTEALKLCFCPLAVLLQALLQFKRKMGARETRRLLERVVYQPGYPKSIASTARWYLLRHLYAKDDYELIDVLVNNAKTHGDTRALELNQRLSSQ
What is the function of this protein?
Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
What are the official names of this protein?
SKI3 subunit of superkiller complex protein, SKI3 homolog, Ski3, Tetratricopeptide repeat protein 37, TPR repeat protein 37, Tricho-hepatic-enteric syndrome protein, Thespin.
Protein: RS3A_SALSA
Sequence: MAVGKNKRLTKGGKKGAKKKIVDPFSKKDWYDVKAPAMFNIRNIGKTLVSRTQGTRIASDGLKGRVFEVSLADLQNDEVAFRKFKLISEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRTNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSVGKDIEKACQSIYPLHDVYVRKVKMLKKPKFELGKLMELHGEGGGSSAAKPSGDDTGAKVDRADGYEPPIQETV
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).  May play a role during erythropoiesis (By similarity).
What are the official names of this protein?
40S ribosomal protein S3a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOC_MYCGE
Sequence: MKLEYNRIIDSTLVKADTLPHEIDTLCADAHKYQFFAVCVNPSYVSYAKNILKNTAVQLCCVVGFPLGQTTQKQKVYEAKIAIKEGADEIDMVMNIAEFKKRCACVITEIRAVKKVCGKRKLKVIIETALLTNDEIKDAVNVCIDGNADYVKTSTGFSFRGASLEDVQIMNNAAANLIKIKASGGIKTAKQFIDLFQAGASRIGTSNAVQIMQELKKMNHEYH
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC27_TITOB
Sequence: DEGPKSDCKP
What are the official names of this protein?
Toxin To27, Toxin Tc27.
What are the subcellular locations of this protein?
Secreted.
Protein: SYP_NITEC
Sequence: MRVSQFFLSTLKEAPAEAELASHRLMLRAGLIKRLGSGLYTWMPLGLRILHKIEHIIREEMNSSGALELLMPAVHPAELWQESGRWDVFGPQMLKIQDRHQHDFCFGPTHEEVIVDIARREIKSYRQLPINFYQIQTKFRDEIRPRFGVMRAREFIMKDAYSFHADLGSLEQTYQLMHETYSRIFTRIGLKFRAVAADTGAIGGSGSHEFHVLADSGEDAIAFCPDSDYAANIELAEAISHGILRKDPAGVMKKIATPDRKSCSDVAEFLSVPIEQTLKTLAVIADGRFYLLLLRGDHQLNETKTRKIPFLSNFEFADESRIIAKTGCLPGYLGPIGVKTEIIADRAVLEMSNFVCGANEEGYHLTQVNFERDLPLPVQVFDIRNVVTGDPSPDGKGMLEICRGIEVGHIFQLRTKYSEKMKATYLDESGQTQILEMGCYGIGVSRIVAAAIEQNCDERGIIFPVAIAPFQLSIIPIGYHKNLQIQAEVEKLYRACRAAGIEVLLDDREERPGVMFADQELIGIPHRIVIGERNLRDGMVEYQGRLDKTSRLLSLQEVIPVIREICGG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACH1_DEBHA
Sequence: MSSILKQRVRYAPYLQKLRTAEQCVELFKHGQYLGWSGFTGVGAPKVVPDAIADHVEKNNLQGKLGFNLFVGASAGPEEGRWAENDMLLRRSPHQVGKPIAKAINTGKTKFFDKHLSMFPQDLTYGFYTREKENDLLDYTIIEATAITEDGSIVPGPAVGASPEMISVSDKIIIEVNTVTPSFEGLHDIDMPVNPPFRQPYPHTTVDYRTGLTAIPVDPSKVVAIVESQTRDKVPPNTPSDETSRNIANNLLEFFEHEAKLGRLPENLHPLQSGIGNIANAVVEGLADSKFKNLTVWTEVLQDSFLDFFESGSLDFATATSIRLTEAGFDKFYENWDTYSKKLCLRSQVVSNSPEIIRRLGTIAMNTPVEVDIYAHANSTNVMGSRMLNGLGGSADFLRNSKLSVMHTPSARPSKTDKTGVSCIVPFATHVDQTEHDLDIVVTDQGLADLRGLSPKERAREIITKTSHPDYRDQLTDYLDRATFYAEKSKCLHEPHILQDAFKMHLNFQENGTMKLDSWDKKF
What is the function of this protein?
Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.
What are the official names of this protein?
Acetyl-CoA hydrolase, Acetyl-CoA deacylase, Acetyl-CoA acylase.
What is the protein family that this protein belongs to?
Belongs to the acetyl-CoA hydrolase/transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAR1A_BRACM
Sequence: MFVIDWFYGVLASLGLWQKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKKELDALLSDESLATVPFLILGNKIDIPYAASEDELRYHLGLSNFTTGKGKVDLVGSNVRPLEVFMCSIVRKMGYGEGFKWLSQYIK
What is the function of this protein?
Involved in transport from the endoplasmic reticulum to the Golgi apparatus.
What are the official names of this protein?
GTP-binding protein SAR1A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus.
Protein: YKZP_BACSU
Sequence: MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSKQGQQGGM
What are the official names of this protein?
Uncharacterized protein YkzP.
Protein: RCF1_CANAL
Sequence: MSVRLPSSMSYGEEEEPDVLQKMWDKSKQQPFVPLGSLLTAGAVLLAARSMKRGEKLKTQRYFRYRIGFQLATLVALVGGGFYYGTETSQHKQTREDKLREKAKQREKLWIEELERRDAIIQARKQRLEESKKELRELAKQGFIEEKESNDKKED
What is the function of this protein?
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
What are the official names of this protein?
Respiratory supercomplex factor 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RCF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: APC13_SCHPO
Sequence: MDSNYNYVHMNKPGVVLFASDWLKDRLPVDDVEVRVEHLPPVTEDEMTIQHSSANLILMKNKQLRHEPAWKDLELEDLVNAFAFIQGSSNAEGKNTIEDNFETDPFKSVKEAPMAPFLEANRRHQGEHASMRYFR
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.
What are the official names of this protein?
Anaphase-promoting complex subunit 13, 20S cyclosome/APC complex protein apc13.
What is the protein family that this protein belongs to?
Belongs to the APC13 family.
Protein: A1KA5_LOXDE
Sequence: WIMGHMVNAIAQIDEFVNLGANSIETDVSFDDSANPEYTYHGVPCDCGRTCTKWEYFNEFLKGLRKATTPGDSKYHEKLVLVVFDLKTSSLYDNQASDAGKKLAKSLLQNYWNNGNNGGRAYIVLSIPNLAHYKLTTGFKETLTSEGHPELMDKVGYDFSGNDEIGDVAKTYKKAGVTGHVWQSDGITNCLLRGLDRVRKAVANRDSSNGYINKVHYWTVDKRATTRDALDAGVDGIMTNYPDVIADVLNESAYKAKFRIASYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LdSicTox-alphaIB1av, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NSP3_ROTHW
Sequence: MLKMESTQQMVSSIINTSFEAAVVAATSTLELMGIQYDYNEVFTRVKSKFDYVMDDSGVKNNLLGKAITIAQALNGKFGSAIRNRNWMTDSKTVAKLDEDVSKLRMTLSSKGIDQKMRVLNACFSVKRIPGKSSSIIKCTRLMKDKIEGGEVEVDDSYVDEKMEIDTIDWKSRYDQLEKRFEALKQRVNEKYNTWVQKAKKVNENMYSLQNVISQQQNQISDLQQYCNKLEADLQGKFSSLVSSVEWYLRSMELPDDVKNDIEQQLNSIDAINPINAIDDIESLIRNLIQDYDRTFLMLKGLLKQCNYEYAYE
What is the function of this protein?
Plays an important role in stimulating the translation of viral mRNAs.  These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding.  The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.
What are the official names of this protein?
Non-structural protein 3, NSP3, NCVP4, Non-structural RNA-binding protein 34, NS34.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP3 family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: CYF_CUSOB
Sequence: MHTKNLFYSRPQQITQYLSAFLMMVILTRTSISSAYPLFAQQGYENPREATGRIVCANCHLANKPVNIEVPQVILPDTVFEAVVQIPYDLQLKQVLSNGKKGGLNVGAVLILPEGFELAPPDRISPELKEKIGKLYFQSYRPNIKNIFVVGPVPGQKYKKITFPILSPNPATNRRAHFLKYPIYVGGNRGRGQIYPDGSKSNNTVFNATASGRVKKIIRNEKGGYEIIIKDGSDSNEVVNLLPPGLEPLVSEGDSIKLDQPLTSNPNVGGFGQDVAEVVLQDPSRVQVLLFFFASIILAQIFLVLKKKQFEKVQLTKINL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid thylakoid membrane; Single- pass membrane protein.
Protein: WWP1_MOUSE
Sequence: MATASPRSDTSDIHSGRLQLKVTVSSAKLKRKKNWFGTAIYTEVIVDGEVKKTAKSSSSSNPKWDEQLIVNVTPQTTLEFRVWSHHTLKADALLGKATVDLKQVLLTHNRKLEKVKEQLKLSLENKNGIVQTGELTVVLDGLVIEQEPVTNRSSSPPIEIQQNGDALHENGDPATRTTPRLPVEGTIGIDNHVSTNTVVPNSCCSHVVNGENTPSSPSQVAARPKNAPAPKPVTSAPTSDTVNGESSSVLADNTSTMGTLLPSEDTTSTSNCTSTTTQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSVFDKVRQPEGCVEPLRPQSGNTNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLPNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.  Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity).  Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation.  Ubiquitinates RNF11 without targeting it for degradation.  Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7.  Ubiquitinates SMAD6 and SMAD7.
What are the official names of this protein?
NEDD4-like E3 ubiquitin-protein ligase WWP1, HECT-type E3 ubiquitin transferase WWP1, WW domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus.
Protein: ARGE_SALPA
Sequence: MKNVLPPFIEIYRALIATPSISATEESLDQSNASLITLLAGWFSDLGFNVEVQPVPGTRNKFNMLASTGHGAGGLLLTGHTDTVPFDDGRWTRDPFTLTEHDNKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFSETTALRPDCAIIGEPTSLQPIRAHKGHISDVVRVLGQSGHSSDPARGVNAIELMHDAIGHIMQLRDSLKARYHYEAFTVPYPTLNLGHIHGGDASNRICACCELHMDIRPLPGMTLNDLNGLLNDALAPVSERWPGRLTVAELHPPIPGYECPPDHQLVEVVEKLLGTKTDVVNYCTEAPFMQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVVHHFCWH
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1311_STAS1
Sequence: MNAYEAYMNELATQMRSELTGRDFKSLETADEVSNFMTNVGSDDTTFVVINSTCGCAAGLARPAAVTVVEQNDKKPTNKVTVFAGQDKEATATMRDYIQQVPSSPSYALFKGQELKHFIPREHIEGRDIQDICMDIKDAFDDYC
What are the official names of this protein?
UPF0403 protein SSP1311.
What is the protein family that this protein belongs to?
Belongs to the UPF0403 family.
Protein: ARNT_SALPK
Sequence: MMKSIRYYLAFTAFIALYYVIPVNSRLLWQPDETRYAEISREMLASGDWIVPHFLGLRYFEKPIAGYWINSLGQWLFGATNFGVRAGAILTTLLAAALVAWLTFRLWRDKRTALLASVIFLSLFAVYSIGTYAVLDPMIALWLTAGMCCFWQGMQATTRTGKIGMFLLLGATCGLGVLTKGFLALAVPVVSVLPWVIVQKRWKDFLLYGWLAVLSCFVVVLPWAIAIARREADFWHYFFWVEHIQRFAMSDAQHKAPFWYYLPVLLAGSLPWLGLLPGALKLGWRERNGAFYLLGWTIMPLLFFSIAKGKLPTYVLSCFAPIAILMARFVLHNVKEGVAALRVNGGINLVFGIIGIVAAFVVSSWGPLKSPVWTHIETYKVFCVWGVFTVWAFVGWYSLCHSPKYLLPAFCPLGLALLFGFSVPDRVMESKQPQFFVEMTQAPLASSRYILADSVGVAAGLAWSLKRDDIMLYGHAGELRYGLSYPDVQNKFVKADDFNAWLNQHRQEGIITLVLSIDKDEDISALSLPPADNVDYQGRLVLIQYRPK
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CBY2_CHICK
Sequence: MTMSAFDLTKQSTRCTKPEMDCVFPRMKVRDETFTFIDGKWVNEVHCQPTFVPQRRLLSKKTENEWSIWEENRALWEENQVLRIENRMLWEENKALQYLQSQNKGVQLVYSDTIQQSLQKDHKLSPFFPERHLGFQVSPGNKALQLVRERSSVLEFFHRQNRTVPTIWKDQQAIVVHEENKGASSVQKDTENTTAAGEGSLGPTCQEEHDAKEESTTPTQNDTKIAPSTEDDNEILQALQDLYQILRVFLKEKCLSDDRESLHALQDESKFFQEEYKKLKLQLNNVKNTVSDITTQMEMLEKELIAITFPIYEEAGKNMANEYQLGEM
What are the official names of this protein?
Protein chibby homolog 2, Leucine-zipper protein T/MroI-1, Spermatid-associated protein.
What is the protein family that this protein belongs to?
Belongs to the chibby family. SPERT subfamily.