PharMolix/UniProtQA huggingface dataset:
Protein: CRCB1_CORJK
Sequence: MNTGATLIELLAVALGGGTGAAARYVLDTHLKSKHGWAPLWSLAVVNLLGTVVLGLVLGYTSQHLDGAAGSTSAGETQDILYPLLGIGLAGGFTTFSTVMVEVFTRPQPARRIAGVVGMAVVCCAVFLPALWCGALLAGA
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TUSA_PSEA6
Sequence: MTSNNFGDANHQLDAIGLRCPEPVMMVRLSIRNMQLGETLAISADDHSTTRDIPSFCRFMGHTLIASDVDSKPYRYLIRKDQS
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_ALIB4
Sequence: MILLDGKALSEKIKAEVKLEVEEIVKEKEITPGLAVILVGNDPASATYVASKAKSCENAGIYSVVHKMPETITQEELLQTIAMMNKNPKLDGILVQLPLPKQIDTTVVLEAIDPLKDVDGFHPYNVGRMVSNLDAFLPATPFGVMRMFEEYGIELSGKNVVVIGSSDIVGKPMASLLINAKATVTVCNSRTKDLKAHTLAADIVVIAVGVPFLLKEDMVKDGAIVIDVGINRLDTGKLVGDADFEGLKNKCSFLTPVPGGVGPMTIAMLLKNTIKASKLREKRENRC
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: COX5B_RAT
Sequence: MASRLLRGVGALAAQALRAHGPRGVAATRSMASGGGVPTDEEQATGLEREIMIAAQRGLDPYNMLPPKAASGTKEDPNLVPSVSNKRIVGCICEEDNCTVIWFWLHQGESQRCPNCGTHYKLVPYQMVH
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5B, mitochondrial, Cytochrome c oxidase polypeptide Vb, Cytochrome c oxidase subunit VIA*.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5B family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: SYFA_DESVH
Sequence: MDLLKELESLVPELERGLGQASSLQELEEQRIAFLGRKGRLAQVMAHLPELAPAERPRVGQAANTVKQALTELFEQRKVVLEQAKEAAALSRFDPSLPGRMPWRGSLHPVTLVMEEICSVFGALGYDIVTGPEVENDYHNFEALNMPPEHPARDMQDTLYITESILMRTHTSPLQVRTMKSLRPPVAAIAPGKVYRRDSDITHTPMFHQIEGFMVDHNVSMAELRGTLTSFLRTVFGGDTRVRFRPSFFPFTEPSAEVDISCCICGGKGHVGNEPCRVCKTTGWVEILGCGMIDPEVFKSVGYDPEVYTGFAFGLGVERVAMLKYGIGDLRMFFENDVRFLSQFA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_STRGC
Sequence: MREERPIIALDFPSFDDVKAFLEHFPEDEKLFVKIGMEFFYAIGPEIVHYLKGLGHSIFLDLKLHDIPNTVRSAMSVLGTFGIDMVTVHAAGGVEMMSEAKKVLGDKAKLVAVTQLTSTSEEDMRDCQNIQTTVQESVVNYARKAKEAGLDGVVCSAQEVELIKAATAEDFLCVTPGIRPAGSEIGDQKRVMTPQEAHQIGSDYIVVGRPIIQAENPWDAYHEIKKQWNS
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: TDXH1_SULME
Sequence: MKLYQKFPETQVITTKGPLDFYRDVFEKGKWLFLFAHPADFTPVCTTEFVGFSKVYEEFKRLNVELVGMSVDSIYSHIEWLKDIQERYGIQVPFPLIADPDKRLARLLDIIDEASGVTIRAVFLVNPEGIIRFMAYYPIEYGRKIEELLRITKAALVNYKAKVSLPVDWEPGQEVIVPAPSTIDEAQIRMKLPNAKTWYLTFKKYDELPQDQRVV
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Peroxiredoxin 1, Thioredoxin-dependent peroxiredoxin 1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_SULIK
Sequence: MTEEKIQSYRKKIYVIRQKLKAKKPRFLRYDSDKFFRLGRQEKWRRPYGRDNKTRLKVRGFPAIVSVGYRLPKEVRGFHPSGLRQVIVHNVNDLVKVQNQKDSVIVTIASSVGFKKRLEILNKARELGLKVSNEGVSA
What are the official names of this protein?
50S ribosomal protein L32e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: KDPA_YERPS
Sequence: MVASGFLLIASFMLVLFVLSRPLGGFLARLIEGEPFSALQKVEAGLWRCSGVKNAEMNGWQYALAILCFNLLGIVLLFVLLMTQGSLPLNPEHLPGMSWHLALNTAVSFVTNTNWQAYSGENTLSYLSQMAGLTVQNFLSAATGIAVAFALIRAFARHSATTLGNAWVDLVRITLYVLLPIALIIALIFVSQGVLQNLDGYLHITTLEGVQQTLPMGPVASQEAIKVLGTNGGGFFGANSAHPFENPTAFSNFVQMLAIFLIPCALCFAFGQVVGDNRQGHALIWAMSLIFIVAVVVVMYAELAGNPHLSPLGADSNSNMEGKESRFGILATSLYAVVTTAASCGAVNAMHDSFTALGGMIPLWLMQIGEVVFGGVGSGLYGMLLFVLLTVFIAGLMIGRTPEYLGKKIDVFDMKMTALAILVTPTIVLLGTALALCTEAGRAGILNPGAHGFSEVLYALSSAANNNGSAFAGLSVNTPFYNLLLAAAMFIGRFGVILPVLAIASSLVAKKRQPAGNGTLPTGGPLFIGLLIGTVLLVGALTFIPALALGPVAEHLQVWLAH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACCA_RHIME
Sequence: MHNYLDFEKPISDLEGKILELKKLASEDESVNTSDEIARLEGRVRDAMVEIYSKLSPWQKTQVARHPSRPHFLDYASRLFTEFTPLAGDRNFANDDAIQAGLARFHGTPVAVIGQEKGNDTKSRIKHNFGSPRPEGYRKATRIMEMADRFGLPLITLVDTAGAYPGVNAEERGQAEAIARSTEMCLNVKVPIVTVVIGEGGSGGAIAIATGNRVYMLEHAIYSVISPEGAASILWRDSTRAKEAASNMKITAEDLKSLGVIDGIIPEPVGGAHRDPDAVISRTETVIGDALKELSARNGDELRADRRQKYLNIGRNL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_BACAH
Sequence: MATTKPYRVLLYYMYTTIENPEEFAAEHLAFCNSLELKGRILVAKEGINGTCSGTVEQTEKYMEAMNNDPRFDGIVFKIDEADGHAFKKMHVRPRPELVTLRLEDDINPHEITGKYLEPKDFYEAMKQEDTVIIDARNDYEFDLGHFKGAIKPDIESFRELPDWIRENKEVLEGKKILTYCTGGIRCEKFSGWLVREGYEDVSQLHGGIVTYGKDPEVQGELWDGQCYVFDERIAVPVNQKEHVIVGKDHFTGEPCERYVNCANPECNKKILCSEENEAKYLRACSHECRVSPRNRYVIQHELTEEQVAAALEKIEAGK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: NSP4_ROT18
Sequence: MEKFTDLNYTLSVITLMNSTLHTILEDPGMAYFPYIAYVLTVLFTLHKASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVVKEMRRQLEMIDRLTTREIEQVELLKRIHDKLVMQSTGEIDMTKEINQKNMKTLEEWESGRNPYEPKEVTAAM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: WNT7_STRPU
Sequence: SGSCTTKTCWTMLPNFRSVGDVLKEKYERTLQVEPVKAKRTRRPTFLKVKDSENYRKPRLSHLVFLHRSPNYCEFDENNGSMGTVGRRCNRTSTSTDSCDLMCCGRGYNTHQYTKIWQCNCKF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.
What are the official names of this protein?
Protein Wnt-7.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: SRY_PHOLR
Sequence: MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHSRMEDQLSSSQPVNIANSLLQQEHHYRSTSLRDSPETLAAHLSADPPFYPKEQLGLSDAYFP
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: RPOC2_HORVU
Sequence: MAERANLVFHNKEIDGTGMKRLISRLIDHFGMGYTSHILDQLKTLGFYQATTTSISLGIEDLLTIPSKGWLVQDAEQQSFLLEKHYYYGAVHAVEKLRQSVEIWYATSEYLKQEMNSNFRITDPSNPVYLMSFSGARGNASQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTADAGYLTRRLVEVVQHIIVRRRDCGTIRGISVSPQNGMTEKLFVQTLIGRVLADDIYIGSRCIAARNQDIGIGLVNRFITAFRAQPFRAQPIYIRTPFTCRSTSWICQLCYGRSPTHSDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTADLVRSPSNGKIQFNENLVHPTRTRHGQPAFLCYIDLHVTIQSQDILYSVNIPSKSLILVQNDQYVKSEQVIAEIRAGTSTLHFKERVQKHIYSESDGEMHWSTDVYHAPEYQYGNLRRLPKTSHLWILSVSMCRSSIASFSLHKDQDQMNTYGKKDREILDYSTSDRIMSNGHWNLIYPSIFQDNSDLLAKKRRNRFVIPLQYHQEQEKELISCFGISIEIPFMGVLRRNTIFAYFDDPRYRKDKKGSGIVKFRYRTLEEEYRTRAEDSEEEYETLEHEYRTREDEYETLEESKYGILEDEYEYETLENEYGSPENKYGNPENEYRTLEKDSEEEYGNPESKYRTQEDEYGTLEEDSEDEYGSPGESGEEKYGTLEEDSEEDSEDEYESPEEDSILKKEGLIEHRGTKEFSLKYQKEVDRFFFILQELHILPRSSSLKILDNSIIGVDTQLTKNTRSGLGGLVRVKRKKSHTELKIFSGDIHFPEEADKILGGCLIPPERQKKDSKESKKKKNWVYVQRKKILKSKEKYFVSVRPTVAYEMDEGRNLATLFPQDLLQEENNLQIRLVNFIYHENSKLTQRIYHTNSQFVRTCLVVNWEQEEKEKAGASLVEVRANDLIRDFLRIELVKSTISYTRKRYDRTSGGPTPHNRLDRANSNSFYSKAKIESLSQHQEAIGTLLNRNKEYQSLMILSASNCSRIGLFKNSKHPNAIKEWNPRIPILEIFGPLGAIVASISHFSSSYYLLTHNKILLKKYLFVDNLKQTFQVLQELKYSLIDENKRISNFDSNIMLDPFLLNCHFVHHDSWEETLAIIHLGQFICENVCLFKSHIKKSGQIFSVNMDSFVIRAAKPYLATTGATVNGHYGEILYKGDRLVTFIYEKSRSSDITQGLPKVEQIFEARSIDSLSPNLERRIEDWNERIPRILGVPWGFLIGAELTIAQSRISLVNKIQKVYRSQGVQIHNRHIEIIIRQVTSKVRVSEDGMSNVFSPGELIGLLRAERAGRALDESIYYRAILLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGIIPVGTGFQKFVHRSPQDKNLYFEIKKKNLFASEMRDFLFLHTELVSSDSDVTNNFYET
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL24_METMJ
Sequence: MVRIVSKQPRKQRKARYNAPNHTRGRFLSAALSPELRGKYNSRRTRVVKGDTVKVLRGDFAGDEGVVDAVDMKACRLVVHGVMVTKADGTEVPRPVDPSNVQITKLNLKDKLREERLGGGA
What is the function of this protein?
Located at the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: YADG_ECOLI
Sequence: MTIALELQQLKKTYPGGVQALRGIDLQVEAGDFYALLGPNGAGKSTTIGIISSLVNKTSGRVSVFGYDLEKDVVNAKRQLGLVPQEFNFNPFETVQQIVVNQAGYYGVERKEAYIRSEKYLKQLDLWGKRNERARMLSGGMKRRLMIARALMHEPKLLILDEPTAGVDIELRRSMWGFLKDLNDKGTTIILTTHYLEEAEMLCRNIGIIQHGELVENTSMKALLAKLKSETFILDLAPKSPLPKLDGYQYRLVDTATLEVEVLREQGINSVFTQLSEQGIQVLSMRNKANRLEELFVSLVNEKQGDRA
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YadG.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: ZNUC1_HAHCH
Sequence: MNPPPLIRLQDVTVKIQGRTLIENVTFDINSGEIITVIGPNGAGKSTLAKALLGIQPLSRGEVLRRPGLKIGYMPQRFHIDASLPLTVKRFLQLAHNPQRWREALQRVEMEHVAKQPMHTLSGGELQRVLLARALQRAPDLLVLDEPAQGVDVTGQAELYRLIRSLRDELHCGALLVSHDLHLVMASTDQVLCLNRHICCAGHPEKVSNEPAFINLFGTQAARSLAVYHHHHDHHHHTDGTVAAGSECSHGDQHA
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NFUA_ALISL
Sequence: MTSINITESAQEHFAKLLAQQPEGTNIRVFVVNPGTQNAECGVSYCPPEAIEANDTELKFENLSAYVDELSLPFLEDADIDYVTDKMGSQLTLKAPNAKMRKVNDDAPLFERVEYAIQTQVNPQLAGHGGHVSLMEITEAGIAIVQFGGGCNGCSMVDVTLKEGIEKELLAQFEGELTAVKDLTEHDRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: CLSA_ECOBW
Sequence: MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWQRVAERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NADD_HELPH
Sequence: MNTMNSVLQCKELALYGGSFDPLHKAHLAIIDQTLELLPFVKLIVLPAYQNPFKKPCFLDVQTRFKELERALRGIDRVLLSDFEIKQERAVPTIESVIYFQKLYCPKTLYLVIGADCLRHLSSWTNAKELLKRVELVVFERIGYEEIQFKGRYFPLKGIDAPISSSAIRASLGV
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: ARGJ_PYRTR
Sequence: MSLARPNARLLSRTNRVFSSQIRTYSAPGDGVIPPAKKKYVPTSGTYPRGFKVGSAHVGVKASNTRFDDLALITSDTPCAAAAVFTKNKFQAAPVTVSRDLLKERGGQGIRAVIVNSGCANAVTGKGGIEDAKSMAKHTDACFTDSPDSPDSPYRSIVMSTGVIGQRLPIDKITSKIPTAFANLGDTHDHWLGTARAICTTDTFPKLMSKTFKLPSSDREYRIAGMTKGAGMIHPNMATLLGIICTDVPVAYFPLRRILASAANKSFNSISIDGDTSTNDTVAILANGAAGGDLIDTKFHSDFESLKQVITDFSIDLAKLVVRDGEGATKFVTIRVTNARSITDARRIASSIARSPLVKTALYGKDANWGRILCATGYSTARNPAVPEETSVSFVPTDGSEELKLLVNGEPEQVDEARAAKILEAEDLEIKVSVSNTPGKDTWFWTCDFSHEYVTINGDYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PROA_LISMO
Sequence: MTELIKKGSAAKEAAQFLAQASTKQKNAALLNLSNDLLTHTASLLEENNKDIIRAREKGTPETMIDRLRLTEERIKEISEAVKQVVALKDPIGEVTNMWKNEAELTIGKTRVPLGVIGIIYESRPNVTVDASVLCFKTGNAVILRGGSDAIDSNKALMSVIQDSLEASGFPRSSVQLIEDTSRETARDMMRLNRFLDVLIPRGGAKLIQTVLENATVPVIETGTGNCHIYVDKAAEKQMAIDILVNAKCSRPSVCNAAETLLIHRDVADAFLPEIETALKEYNVELRADERAREILKDSKAATESDWEDEFLDFILAIKVVDSVDEAINHINKYGTKHSEAIISNDYATGQAFHQKVDAAAVYINASTRFTDGFAMGFGAEIGISTQKLHARGPMGLTELTSTKYIIFGDGQIRN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLX3_MOUSE
Sequence: MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESTVTDLGYYSAPQHDYYSGQPYGQTVNPYTYHHQFNLNGLAGTGAYSPKSEYTYGGSYRQYGAYREQPLPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARNPLPPPLPYSASPNYLDDPTNSWYHTQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY
What is the function of this protein?
Likely to play a regulatory role in the development of the ventral forebrain.  May play a role in craniofacial patterning and morphogenesis.
What are the official names of this protein?
Homeobox protein DLX-3.
What is the protein family that this protein belongs to?
Belongs to the distal-less homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YN4B_SCHPO
Sequence: MSISNDSLASTVPGDELPSSYPVFSSDFSYIKPSHVLDVVTVTSTAGPEATDDPSYSGFYSTVISTQNPEPTSASTPPSASASSLPNGAQKHNHTGVIAGPIVGVLGGLIVLVIIFYCLRHFKRKKFLAEQQEFERQFEEEKSRLAAVRKNTEQEKMGYRGGYQMHSTPWASSPRNSTIPQRSQSFYNDTRRSSDLGANAADFVTPPGNVANSDNIRILKRNSIATIGNYRSPSALEKRRSISYGAVQSVQGRPLAPIPGRRPLSISSDLYNDSNSGSHSNDDSDETKLKQSSTESSSELLDEKDKFDKNSLNDPFVTIRKSSYEHEISEEHKKHSKKRSEHF
What are the official names of this protein?
Uncharacterized protein C36.11.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass membrane protein. Note=Localizes to the cell tip and the barrier septum.
Protein: PYR4_ASPFU
Sequence: MDGWSDLSSAPPQYREVAGIADWALLAQGLGWSINYLAMIYHSYKDRTYGMAILPLCCNFAWEFVYSVIYPSHNSAERAVLTTWMILNLFVMYTAIKFAPNEWQHAPLVRQCLPWIFPVAIAAFTAGHLALAATVGVSKAANWGAFLCFELLTSGAVCQLMSRGSSRGASYTIWLSRFLGSYIGGIFLHVRETHWPQEFGWISHPFVTWHGLMCFSLDIAYVTFLWRIRRQEHRSQRKKAL
What is the function of this protein?
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor (PubMed:20861902).  The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1 (PubMed:20861902).  Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO (PubMed:20861902).  The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E (PubMed:20861902).  The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps (PubMed:20861902).  Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8 (PubMed:21224862, PubMed:26019565).  Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9 (PubMed:21224862).  Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8 (PubMed:26019565).
What are the official names of this protein?
Terpene cyclase pyr4, Pyripyropene synthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.