PharMolix/UniProtQA huggingface dataset:
Protein: PI42A_RAT
Sequence: MATPSNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYVIKTITSEDVAEMHNILKKYHQYIVECHGVTLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDSNKKIFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENEGEEEGESDGAHPIGTPPDSPGNTLNSSPPLAPGEFDPNIDVYAIKCHENAPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
What is the function of this protein?
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).  Has both ATP- and GTP-dependent kinase activities.  May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity).  May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (PubMed:20204506).  Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (By similarity).  In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity).  Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (By similarity).  Negatively regulates insulin signaling through a catalytic-independent mechanism.  PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:21847559).  May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity).
What are the official names of this protein?
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, PIPK2 alpha, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, PI(5)P 4-kinase type II alpha, PIP4KII-alpha, PtdIns(5)P-4-kinase isoform 2-alpha.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Lysosome. Cytoplasm. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B (By similarity).
Protein: SYGA_YERPA
Sequence: MQKFDTKTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRAIGPEPIAAAYVQPSRRPTDGRYGENPNRLQHYYQFQVIIKPSPDNIQELYLGSLKELGLDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLIWCDGPLGTTTYGDIYHQNEVEQSTYNFEYADVDFLFSCFEQYEKEAQSLLALETPLPLPAYERILKAGHTFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCKKNQN
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GTDC1_CHICK
Sequence: MSVLLIEAFYGGSHKQLMDLLQEELKEECVLCTLPAKKWHWKARTAALYFMQTVPASANYRILFASSVLNLAELAALRPDLGKLKKVLYFHENQLAYPVQKCKERDFQCGYNQVLSCLVADTVVFNSAFNMESFLTSIGKFMKLIPDHRPKDLEKIIRPKCQVLYFPVRFPDVSRFMPEHKLAHLENVIGVKRNGDFYQREGLPGQQKSRALGGLMKNSNACRESGLCETQPGLCTTQHEGLHSPLTAAGRLNKSEASESTNPCQEEDKQHVTFNLCNIWSGMDYLQRPLHVVWPHRWEHDKDPETFFKVLLKLKEQELPFHVSVLGETFTDVPGWKRCIVAVTRCVPRPWCTRRSSQLNICILHLNSFLKGFRISARDQIL
What are the official names of this protein?
Glycosyltransferase-like domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: DNAG_METAR
Sequence: MEESDTTKYVIHAHISAEGVVERPDVVGAVFGQTEGLLGADLDLRELQKTGRIGRIEVNITSKYGKSNGNILIPSSLDKVETSILAAALETIDRVGPCISKITVTKIEDVRSSKRKQIIDRAKHILTDMFDNSVPESQEITDAVKAAVRVEEVTFIDNLPAGPNVLDSDAILVVEGRADVLNLLKYGIKNAIAVEGTNVPQLVAELSKKKTVTVFTDGDRGGELILKELLQVADVDYVARAPDGKGVEELTQKEVVKSLRSKVPVEQVIEVPQGRRRNKLAAQAAEKQAQAEAAQKAEAPAAAAPVQPQREYQQKEYPQRESRERSEQPRGEVPRRKSLRRTEEQQERPERPERSERAERREYRERREYREPREPREQREQAPARKEREPSEFDEMMKELSGTLSARLLDANKNVINTVAVRDLANTLKESNGDVKSVVFDGVITQRMLDIAAEKNLETLVGVKMGSVVKQPAGVKVITTE
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Also part of the exosome, which is a complex involved in RNA degradation.  Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: RECA_RHIME
Sequence: MDKSKALEAALSQIERSFGKGSIMKLGAKDSVVEIETVSTGSLGLDIALGIGGLPKGRIIEIYGPESSGKTTLALQTIAEAQKKGGICGFVDAEHALDPVYARKLGVDLENLLISQPDTGEQALEITDTLVRSGAIDILVIDSVAALVPRAEIEGEMGDSLPGMQARLMSQALRKLTASISKSNCMVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGSVKEREEVVGNQTRVKVVKNKMAPPFKQVEFDIMYGEGVSKTGELIDLGVKAGIVEKSGAWFSYNSQRLGQGRENAKLFLRENPELLREIETALRQNAGLIADRFLENGGPESDGDEAADM
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPX2_PATPE
Sequence: MADVEMMEYVDDVYEMDCPKFVDFSVPQVVDDNADEWFNFDHENGVPLTFDDKAVSPTAKETPTSPLPQDPQESHSVIGHSETDTTLQESSAPEIATSEKQKYASPSDDVSSAESETCEMSTDSMQDKPAVPESAVRNVTDDEATVQESSDAEETQTLPSSCVDSSTAEMSTDSLEDKPQKPQMQESPKPRKRYGNLVTSFARRDEDTTTASSDHSEPEQKKPRSRQRSVEVVSRPTRKSPRLHSRRSAEPTRLKRPSITSQAVKRRSANSALGHPRSRVLSTDQPISKRRKIGSEITPAGRPDAKKSCPKLKAKINLTMPTTPTLLKRNLAKPNTQLKTTEQMELDRIAQFQHKLAAIRKKSALSYKAVKESVPVAPVHAAVQPTRPEEFKFETDARLKSHTMETRKDTKNKDFVGNLRKYVPSPSKPQGITKPRPFNFSDNRKRTHEESFSGEKKGYEFKATALAVSQFHTKTPDRFRSKPLSEQNKGPEPAHDRPKKAKLTQPMTPALESRNRHRPVTAISQAQREEQELADMKNYKFKARPVDPRVMSNIAVGVKTVHHKEPTKPIGFDLEIEKRLLERETNKVQTEERYEFRARPLPAKILAGPVGIAEAKAAAVTIPKSPAFALKERVKVYKEKEREKEKDSEHDNSHIIKARPILHAGVPFMPNIQHKRTEPEPFSFDEKIQESKARKEAKIQETLREEERARQFRAQPLPDLTWCSGVPDKKVKPPTQMAPFSVAEKGAKQAEEWSKKMEEEIRDCKRMANAFKAKPANILYEEPFVPEKSTKPMTDISNFSLNTERRAEDRKGYEQAKYERQLAQDTAQAQREAEKEEELRQQISKQRADSIHKAKPVRHYKAVEVLPSTKPLTQPKTPKFSDRTRRSSHTS
What is the function of this protein?
Spindle assembly factor.  Required for normal assembly of mitotic spindles (By similarity).
What are the official names of this protein?
Targeting protein for Xklp2 homolog, TPX2 homolog, Microtubule-associated protein TPX2 homolog.
What is the protein family that this protein belongs to?
Belongs to the TPX2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle.
Protein: CAPP_ACTP2
Sequence: MNQPYSAMRNNIHMLGDFLGETIREAQGNEILELIESIRVLSRDSRAGDEKAREQLLDKLANISTENVLPVARAFSQFLNLTNIAEQYQTISRHHQDESLGNRSLSALFARLKAQGTPVETVIKTVEKLSIELVLTAHPTEVTRRSLVHKHVEINKCLGQLEHDDLTEAEQTKLKRRLMQLIALAWHTNEIRAARPTPVDEAKWGMAIIENSLWKAVPDFCRELNFQLEKHFDVQYEVALSPVRFSSWMGGDRDGNPFVTAEITQKVLRMNRWKAAELFLNDVSDLVEELSIVQCTPEFREKYGDHIEPYRVVVKGLRSKLQKTLTYFGELIEAKPTTVDPSEIITCDNDLWEPLYDCYQSLHACGMRIIANGSLLDCLRRIRCFGLGLSRLDIRQESSRHETAIAEITRYIGLGDYAQWTEDDKQAFLVRELSSRRPLVPTNWTPSPETQEILDTCKVVAQQPEGTISAYVISMAREASDVLAVHLLLKEAGCNYTLPVAPLFETLDDLDHSEKVMTDLFNIGWYRGVINNYQMVMIGYSDSAKDAGMLAASWAQYRAQEALVNLAEKYHIELVLFHGRGGTVGRGGAPAHAALLSQPPRSLKSGLRVTEQGEMIRFKLGLPAVAVETLNLYASAILEANLLPPPEPKQKWRDIMDKGAAISCEIYRGVVRGEPDFVPYFRSATPEQELGKLPLGSRPSKRNPNGGVESLRAIPWIFAWMQNRLMLPAWLGAGAALRQMIEQGEESTLKEMCNEWPFFSTRIGMLEMVFSKADLWLAEHYDQRLVAKELHRLGKTLRAQLSADIQTVLTLAHDGQLMADLPWIAESIALRNVYTDPLNLLQVELLQRLRSQGEVRDPQLEQALMITITGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: NS12_CVMJH
Sequence: MEIWLVSDAWLRRTRDFGVTRLEDFCFQFNYCQPRVGYCRVPLKAWCSNQGKFAAQFTLKSCEKSGHQKFITSFTAYGKTVKQAVSKLVEEAADFIIWRATQLERNV
What are the official names of this protein?
Non-structural protein of 12.7 kDa, ns12.7, 12.7 kDa accessory protein.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses 12.7 kDa protein family.
Protein: GLNE_SALTY
Sequence: MTPLSSPLSQYWQTVVERLPEGFTETSLSVQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRFFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRVAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEERRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLADVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: PUR2_XYLFT
Sequence: MKLLVIGSGGREHALVWKLAHSRRVSEIIVAPGNAGTATETKCRNAPVQVTDLDGLLALAQREAVNITVVGPEVPLVAGIVDCFRAAGMRIFGPTAAAAQLEGSKAYAKDFMARHGIPTARYAVHTNVDAAISDVRQQGAPIVIKADGLAAGKGVIVAMTVTEAEAAIRDMLSGNAFGHAGARVVIEEYLDGEEASFISMVDGTHALPMATSQDHKRVSDGDIGPNTGGMGAYSPAPIITDEIHARVMREIVNPTVAGMIADGTPFMGFLYAGLMIDVHGAPKVIEFNVRFGDPETQPVMMRLQSDLLDLIEAALNGDLDKVQAQWDPHPSLGVVMAARPYPEMPITGEVISGLDALPANVKVFHAGTALDVAGRVVTAGGRVLCVTALGSNVSEAQRHAYGGVASLHWANAFQRSDIGWRAIMREHTVR
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: UBIA_PSYA2
Sequence: MTFNDKLQAYIQLTRFDKPVGIELLLWPTLWGVLFAAMGQAQQQGEGVTAGLPSLSIFVVFALGAILMRAAGCAINDFADRKVDGHVSRTKGRPLADGRLSAKEAIAAFLVLVLLSASLLLFLPIQVFYWSFAAVILAFIYPFMKRYTHLPQVFLAAAFGWAIPMAYVAIQGAADIWCWLLFLAYMCWTVAYDTQYAMADRDDDVKIGVKSTAILFGRYDVIIISLLQILFLVIMGAVMWHYFVPTSLGITPVFGLALVAMMFAKQNSACASRNALACFQAFLANIWVGRYVFALIAIACVWTTFNG
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RR12_PINCO
Sequence: MPTIQQLIRNARQPIENRKKSPALRGCPQRRGVCARVY
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PA2C_PSEPO
Sequence: NLIQLSNMIKCAIPGSRPLFQYTDYGCY
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 pseudexin C chain, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARMC3_HUMAN
Sequence: MGKKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEVNVSGTRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSNIINDGFYDYGRINPGTKLLPLKELCLQEPSDLRAVLLINSKSYVSPPSSMEDKSDVGYGRSISSSSSLRRSSKEKNKKNSYHFSAGFGSPIEDKSEPASGRNTVLSKSATKEKGWRKSKGKKEEEKVKEEEEVMVVPKFVGEGSSDKEWCPPSDPDFSMYVYEVTKSILPITNIKEQIEDLAKYVAEKMGGKIPKEKLPDFSWELHISELKFQLKSNVIPIGHVKKGIFYHRALLFKALADRIGIGCSLVRGEYGRAWNEVMLQNDSRKGVIGGLPAPEMYVIDLMFHPGGLMKLRSREADLYRFI
What are the official names of this protein?
Armadillo repeat-containing protein 3, Beta-catenin-like protein, Cancer/testis antigen 81, CT81, KU-CT-1.
Protein: EFR3_CAEBR
Sequence: MNGLCCCTPCKPRYRRLVDSIYPRAVTDGLLHSNMQKLTFYAISHPEKLERIGEYLVMRMVRDLNRQRPVQVKIAVEAMDQLLQACHSSPSLPQFSENHLRMVQRLLESNNAKMEQLATDSFVTFSNIEESSPSYHRQYDFFIDKFSQMCHANPQAAYGEDFRLARCAGLRGLRGVVWKSVTDDLHPNIWEQQHMDKIVPSILFNLQEPDDNGGFSSSHIPKFDNNFTDSTQSHRGDDEATPKVLSDRCLRELMGKASFGSLRAVIEPVLKHMDLHKRWSPPPSFAIHVFRAIIYSIQSQNSYFVIQELINHLDSMCSADASTRIGIATVLSSIVSIAGTSIGPLLLSIFNSLLKHLRTSVDFERSGKCSDQPAEKMYQEALINAMGDFANALPDYQKVEMMMFTVGNIPNLDERKSKQGEEFLQHVLVKTLLKVATKYRTAYLATVFTDSFLDTLLRLALVRDPQVRLATQQIFHTLLDRHDNAANLVHLGYELDVADVQLTVEKCSRADQMFMRKHIGDITYMLWRAAAAADETDLSTHADAILCTMSLLCIESLVELFRLSMALQQLALDTKQNFSDAKRNSIHNIVAKYMNLSAQLIANPSLCQQVQHVVGCRAQRGIPGLNLLLSVKESPMNDDPLSSTAVNGTIPEGTPRTITEGDHALLFNIEDVAESLKASGKDASRLFVPFNMSLNGRDGNGDSWQREDGQNFDSTDGRESPDGYKTVGIDDVSVDMSVDWTPPISRKQSRRNTIFSIVNPPKLNASTVDDLKAYANASFDPIEEDRKEKELTGSILSEIRNTDFEERVNTNESLNERGDLSKSIARLLVRNGETTKVRDIGRPTKPKNVFEIELPSFAY
What are the official names of this protein?
Protein EFR3 homolog.
What is the protein family that this protein belongs to?
Belongs to the EFR3 family.
Protein: Y2292_MYCTO
Sequence: MNPGFDAVDQETAAAQAVADAHGVPFLGIRGMSDGPGDPLHLPGFPVQFFVYKQIAANNAARVTEAFLQNWAGV
What are the official names of this protein?
Uncharacterized protein MT2349.
Protein: NRDR_BACAN
Sequence: MRCPSCSHNGTRVLDSRPVDEGRSIRRRRECESCLSRFTTFERVEESPLIVVKKEGTREEFNKEKILRGLIKACEKRPVSLRQLEEVTQSVERELRNLGISEVKSDMIGEIVMEELRDIDDVAYVRFASVYRQFKDLNVFIEELKDILQKERE
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PSB1_PYRFU
Sequence: MEKKTGTTTVGIKVKDGVVLAADTQASLDHMVETLNIKKIIPITDRIAITTAGSVGDVQMLARYLEAEARYYYFTWGRPMTTKAMANLLSNILNENRWFPYLVQIIIGGYVDEPTIANLDPFGGLIFDDYTATGSGTPFAIAVLEEGYREDLTIEEAKELAIRAVRAAGRRDVYTGSKKVQVVTITKDGMKEEFVV
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 1, 20S proteasome beta subunit 1, Proteasome core protein PsmB 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANS1B_HUMAN
Sequence: MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPLVKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF
What is the function of this protein?
Isoform 4 may play a role as a modulator of APP processing.  Overexpression can down-regulate APP processing.
What are the official names of this protein?
Ankyrin repeat and sterile alpha motif domain-containing protein 1B, Amyloid-beta protein intracellular domain-associated protein 1, AIDA-1, E2A-PBX1-associated protein, EB-1.
What are the subcellular locations of this protein?
Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. SUBCELLULAR LOCATION: [Isoform 3]: Postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note=The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). SUBCELLULAR LOCATION: [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed. SUBCELLULAR LOCATION: [Isoform 6]: Nucleus.
Protein: Y1297_PYRFU
Sequence: MVSMNMFEEVEVEAYVYPTEDIEKVKKAMLNLVPGLKFEAFDKGEYMILVGRTRDKRALQRLYELFRGQQILDTARMMLEEGYFGEEIIIKVHKQVAYVGKVNFNEESPLGPITIIIRTKEPQKLMKWLAPRTKDGVPIE
What are the official names of this protein?
UPF0201 protein PF1297.
What is the protein family that this protein belongs to?
Belongs to the UPF0201 family.
Protein: Y010_MYCTU
Sequence: MQQTAWAPRTSGIAGCGAGGVVMAIASVTLVTDTPGRVLTGVAALGLILFASATWRARPRLAITPDGLAIRGWFRTQLLRHSNIKIIRIDEFRRYGRLVRLLEIETVSGGLLILSRWDLGTDPVEVLDALTAAGYAGRGQR
What are the official names of this protein?
Uncharacterized protein Rv0010c.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RUVC_BARBK
Sequence: MVEKIRIIGIDPGLRRTGWGIIDFLGNHMHFVASGTLHSDAQLNLASRLHQLHKGLSEVVHQFMPHEAAVEHVFVNKDATATLKLGQARAIALLVPAQAGLPVFEYAPNTIKKSVIGVGHGAKEQIHMMVKRLLPRAEFDGHDAADALALVICHSAHRTNFAHRIKG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: Y462_TREPA
Sequence: MRRIVCPPVLFLSASLLTGCDFSGIFASIQSEVPLKIPSIRGVVTGLVKCNNKLYACAGQLWEKDASKSEGKWTAVNFLPGKKITSIVSKGACVYACVSGEGVYTYTSNGAGRTGGTTTPSTVLGKTNGAIRIGGSDNPFLQMPCELSSGSSGGGGGGSGSSSDGGIKNGSDENVLGSGTGYVVTTKAVYTKSNSSGTSCTYTKDGTFTATTSPILGCTSDGKGCFYVLDGTDVHCRTVQASGGGNGAHCAVASGSATSCKVAHTVTNPLCIAHVKNGQTEFLLIGGSQGYKEIKLETGSGSGTGCLKAENVRGPEQWGEDSVTPKDRVSQYEGTIGRFAISDIYTVESTSGAGGTNGGTNKPDVYVVVGDSQDGYTGLWRFDAQKKEWNRE
What are the official names of this protein?
Uncharacterized lipoprotein TP_0462/TP_0463.
What is the protein family that this protein belongs to?
Belongs to the TP013X lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RBFA_SHELP
Sequence: MAREFSRTRRIAQQLQQELAQVLQRDIKDPRIGMVTVNDVDVSRDLNYAKVYVTFFEEDKAVVEEKLAALEAAAGYVRSLVAGRMKLRVMPEIRFIYDASLIEGMRMSNLVSQVITKDKAKAAEHGREDEELDDTEQDDK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QSOX2_HUMAN
Sequence: MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTRALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKKSLPLPEKPHKEENSEIVVWREFDKSKLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAKLFPGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNNKMRISGIFLTNHIKWVGCQGSRSELRGYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEEMAKESMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHEEIKGLASWDEGHVLTFLKQHYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVSHGDRDTQSVRPPGALGPRPALPESLHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLDMSLCVVLYVASSLFLMVMYFFFRVRSRRWKVKHHHPAV
What is the function of this protein?
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.  May contribute to disulfide bond formation in a variety of secreted proteins.  Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
What are the official names of this protein?
Sulfhydryl oxidase 2, Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane.