PharMolix/UniProtQA huggingface dataset:
Protein: IF2_DESOH
Sequence: MAKIRIFELARSLNMTNPDLLDRLKEMGIEAKSHLSSLEDDIVEKVRQGVFRTEVEKPEKVEQKRVRSNVIRKRRQPVKSEAEPEAEAPAAQAPEAEEVTAPTAEEAVPEEAADADVSAKAETPTAPETPEEAEISVSEEAPVEEAADQVPPTDEAVDPAEAAPAEEESSPSRKKAKAKKHQAAKIIKFPDAPQRLSNKGVLEVVDDTAPADSPAAPAAATPAGEKDKKPSRKDRKKRGKTESVETEEAVPVKKKGVFKRKEIVEGVALYDRTRGRMRKKGKGGAKVPGGAKTQITTPKAIKRKVRINESISVAELAKRMGVKASEVIARLMGMGVMATLNQQVDFDSAALVAAEFEYEVEKASATEEELLELNVEEDQGNLKKRAPVVTIMGHVDHGKTSLLDVIRQSRITEGEAGGITQHIGAYKVNTANGEVVFLDTPGHEAFTAMRARGARATDIVILVVAADDGIMPQTIEAINHSRAAGVPIVVAVNKIDKEGADPDRVKREASDHGLVPEDWGGDTMFVNVSAKQKLGISDLLDMVLLQAEMLELKANPDKKARGVVIEAKLDPGRGPVATVLIHEGTLSVGETVVCGIHYGKIRAMFDDKGAPLDQAGPATPVELIGLGGVATSGDDLFAVGDEKSAKTVSENRQQKQRTEDLARKDSISLENFFEKMQEKEEKVLNIIIKADVNGSCEAIADSLQKFSSGEVKIHVVHSAPGTIIESDVTLASASNAIVLGFNVRPSPKVRALAAEENVDIRSYDIIYDLIDDIKKALTGMMSSTFEEEVLGRAEVRELFVIPKKGTIAGSYVLDGKIERGRPARLLRDGVIAYNGVIGSLRRHKDDAKEVASGYECGIGIENYNDIKPGDVIECYFLREIKPEL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBS1_HYDCU
Sequence: MSIQDYPSRLSDPQSRKAETFSYLPKMTAEQIKAQVQYIIDRGWNPAIEHSEPENAFSYYWYMWKLPMFGETDADAVLAEVDACIKANPNNHVRLIGYDNYAQSQGANMLVKRGDM
What is the function of this protein?
Can replace the endogenous type I ccbS gene in H. neapolitanus, reconstituting RuBisCO with about 10% of normal activity; the active enzyme is targeted to carboxysomes (PubMed:18974784).
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit 1, RuBisCO small subunit 1, Non-carboxysomal form I RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_PSEAE
Sequence: MSGTLYIVSAPSGAGKTSLVKALLDAAPEVRVSVSHTTRGMRPGEVDGVNYHFTSREEFLAMLERNEFLEHAEVFGNLYGTSQRWVEKTLAEGLDLILEIDWQGAQQVRRLMPEAQSIFILPPSQEALRQRLTNRGQDSDEVIERRMREAVSEMSHYVEYDHLVINDDFAHALDDLKAIFRARQLRQDAQQQRHAELLGRLLA
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARY2_CALVI
Sequence: MKIAIVLLAIVGLAASASITDKKVKIADKDFLAKQKFLFEIVYRVEDPLMFEEWIKMGKSFTFDKADYNHFDMYMDKFYEAYKYGAILPKGEFFYYAKNWEVFQRNVAFARMHCNEGMFVYALTLAVIHRDDFHGLILPSIYEIFPQYFFNSKFVYEAEKFDYDVWSKYIMYEKEYKDILYKDYATFYKNHDNHYYYFFTKDFKTYQWWKMMGLGEHWYSEDRFMLRDNMDKYNKDSKYLEIFEGTKMFFMPVDYTRDIEFFNKESALSYFTEDVGFNAYWYYLNMDYAFFLDGKTYGLNKDRRGEYWLYNVRQLLSRYYMERLSHGFGEIPAFSFIDSIEYGYNPQLVYHNGVGFSYRKNYYEVESFGKFDYFYKVLDFFNRMDEIITKGVYVTYDGKTIDLRKPESIEYIGSIMQGNVDTLHSYFFKYWYMFAHMYLAYDNTQTLQVFPHIFLNYETSMRDPMFYMFYKKIASVYFQFFNYVKPYTHEELLFPGVTIKDVKVSELVTYFDLVDFDVTNLMNDKMTFVDGQFVWDKTLLARQMRLNHKPFDFDFVIESDKAQKVVIRTYLGPKYDEFGRVISLTENRENFMELDSFLYTLKSGVNEFKRYSKDFYWTVEDRTTYTELYKYVMLALQGKYDFPLDISEPHCGFPDRLVLPHGWYKGMPMQFFFYVTPFTTEYEQFSTYDYSYSCGLGSGVRYIDETCFGYPFDREIDEYEFFVPNMYFKDVKIFHQDTFEKYFEHKYEKFGHFDYNYHH
What is the function of this protein?
Arylphorin is a larval storage protein (LSP) which may serve as a storage protein used primarily as a source of aromatic amino acids for protein synthesis during metamorphosis.  It is a constituent of the sclerotizing system of the cuticle, and serves as a carrier for ecdysteroid hormone.
What are the official names of this protein?
Arylphorin subunit C223.
What is the protein family that this protein belongs to?
Belongs to the hemocyanin family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: NRFA_ALISL
Sequence: MKKQWTRRSAAAIAMVTTLLLSSHSFAASEKTERVDPRNEAYAKQHADQYESWRPTSDSVQIEDALAEDPNMVILWAGYGFAKDYNKARGHFYAIDDVRETLRTAGPTDENSGPMPMACWSCKSPDVGRVIEEQGEDGYFSGKWARLGSEIQNPIGCADCHDTRSEEFKNGGPALAITKPHVERAMNAIGKPFDDQSRLDKQASVCGQCHVEYYFTGKTKAVKFPWDKGTTVDEMEEYYDEIGFSDWTHKVSKAPMLKAQHPGYETWREGIHGKNKVVCVDCHMPKVTREDGTVYTDHKVGNPFDRFEDTCANCHTQSKDMLREIVSSRKAQVLKMKLTAERQIVAAHFEAGAAWDAGATKEEMAPILQDIRHAQWRWDYAIASHGIHMHAPEVALEVLGSAVDRAADARTKLVRLLAKKGITDPIEIPDISTKAAAQKALGMDMEGMEAEKKHFLETVVPKWDQQAKEREAADYHPL
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HIS1_CLOK5
Sequence: MDGERKIKIALTKGRIEKEAVKIFERAGVDCSEVINKGRKLIFHNMESNIDFVLVKAPDVLTYVEHGVVDIGIVGKDTLLEQDKNFYEVLDLGFGKCKFSLAGLKDSNFYSGYNRKKIATKYPNVARSYFRKLGQDVEIIKIEGSVELAPILGLADAIVDIVETGSTLKENGLVIYKDICSISARMVVNMASMKMKKEEIEKIINKVQVQINEIEKAVR
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1126_ANADF
Sequence: MSWARDEAGGVVLELLVQPRASRTRVLGEHGGRLKIQLAAPPVDGAANAALVEFLAEALEVRKQDVVLVRGETGRRKAVRVTSVSAARAVAALVH
What are the official names of this protein?
UPF0235 protein Anae109_1126.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: HSLO_STAA2
Sequence: MTHDYIVKALAFDGEIRAYAALTTETVQEAQTRHYTWPTASAAMGRTMTATAMMGAMLKGDQKLTVTVDGQGPIGRIIADANAKGEVRAYVDHPQTHFPLNEQGKLDVRRAVGTNGSIIVVKDVGMKDYFSGASPIVSGELGEDFTYYYATSEQTPSSVGLGVLVNPDNTIKAAGGFIIQVMPGAKDETISKLEKAISEMTPVSKLIEQGLTPEGLLNEILGEDHVQILEKMPVQFECNCSHEKFLNAIKGLGEAEIQNMIKEDHGAEAVCHFCGNKYKYTEEELNVLLESLA
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABD_STAAW
Sequence: MSKTAIIFPGQGAQKVGMAQDLFNNNDQATEILTSAAKTLDFDILETMFTDEEGKLGETENTQPALLTHSSALLAALKNLNPDFTMGHSLGEYSSLVAADVLSFEDAVKIVRKRGQLMAQAFPTGVGSMAAVLGLDFDKVDEICKSLSSDDKIIEPANINCPGQIVVSGHKALIDELVEKGKSLGAKRVMPLAVSGPFHSSLMKVIEEDFSSYINQFEWRDAKFPVVQNVNAQGETDKEVIKSNMVKQLYSPVQFINSTEWLIDQGVDHFIEIGPGKVLSGLIKKINRDVKLTSIQTLEDVKGWNEND
What are the official names of this protein?
Malonyl CoA-acyl carrier protein transacylase, MCT.
What is the protein family that this protein belongs to?
Belongs to the FabD family.
Protein: RS14_STRPG
Sequence: MAKKSKIAKYQKQLQLIEQYADLRRDLKAKGDYESLRKLPRDSNPNRLKNRDKIDGRPHAYMRKFGVSRINFRDLAHKGQLPGVTKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: TPIS_PROA2
Sequence: MRKKIVVGNWKMNKTIAEAVELSSAIIDQLGEVSASCEVGIAPAFPALSGVHGVISGTGIHLAAQNCHYEDDGAFTGEVSVRMLDEAGCSYVIVGHSERRQYFGDTNPVVNLKVKKALSAGLNVILCVGETLDEREKGITTEVVTCQVKEGLEGVADIGDIVIAYEPVWAIGTGKTASSLQAQEVHASIRATVAGLYSEPAAAGVRIQYGGSVKPSNAEELFAMPDIDGGLIGGASLNAEDFVAIVKAAEKS
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_SALPA
Sequence: MISDIRKDAEVRMEKCVEAFKTQISKVRTGRASPSLLDGIVVEYYGTLTPLRQLASVTVEDSRTLKINVFDRSMGPAVEKAIMASDLGLNPSSAGTDICVPLPPLTEERRKDLTKIVRGEAEQARVAVRNVRRDANDKVKALLKDKAISEDDDRRSQEEVQKMTDAAIKKVDAALADKEAELMQF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_POLNA
Sequence: MAEKKGSSSEKTLYCSFCGKSQHEVKKLIAGPSVFVCDECIDLCNEIIRDELPSGSEAGEARSDLPTPAEIKATLDGYVIGQEPAKRTLAVAVYNHYKRLRHKESAKKDDVELTKSNILLIGPTGSGKTLLAQTLARTLNVPFVMADATTLTEAGYVGEDVENIIQKLLQSCNYEVDRAQQGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLMEGTMASVPPQGGRKHPNQDFLQVDTTNILFICGGAFSGLEKVIENRTEASGIGFGAAVKSKKARSLTEAFKDVEPEDLIKFGLIPELVGRMPVIATLAELSEDALVQILTEPKNAVVKQFSKLLAMEGVDLEIRPSALKAIARKALARKTGARGLRSILEQSLIDTMFDLPTTSNVAKVVVDESTIEENKPPLLVYREAAKKA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: AIP_BOVIN
Sequence: MADIIARLREDGIQKRVIQEGRGALPDFQDGTKATFHYRTLCSDEEGAVLDDSRVRGKPMELIIGKKFKLPVWETIVRTMREGEIAQFCCDXKHVVLYPLVAKSLRNIAAGKDPLEGQRHCCGIAQMHXHSSLGHADLDALQQNPQPLIFDIEMLKVENPGTYQQDPWAMTDEEKAKAVPVIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPDWIQLDQQITPLLLNYCQCKLVAEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQQAQDDFAKVLQLDPAMAPVVSRELRALEARIRQKDEEDKARFRGIFSH
What is the function of this protein?
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
What are the official names of this protein?
AH receptor-interacting protein, AIP, Aryl-hydrocarbon receptor-interacting protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_METPB
Sequence: MSLKIRLTRGGAKKRPYYRIVVADARAPRDGRFIDKVGAYDPMKAKDDPARIVLDNEKIQSWLAKGAQPTDRVLRFLDAAGLAKRPARNNPQKAEPGEKSKERAAKRAEKAAAPAEDAAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: Y308_STAS1
Sequence: MNIQDAQPSTLREMIKQGKLTGHTSGMAKGYVQANVVILPSKCAYDFLLFCFRNPKTCPLLDVSEKGNKSFTKYGVTADISTEVAAYRIYQYGELIETRANVDDLYTDDMVSFLIGCSFTFEHALLEAGIPIRHLEENHNVPMYVTNIPANPSGQFKGNITVSMRPMTMTQAIKATEITTRFKNVHGTPIHIGNPTEIGITDLALPDFGEPVTINENEVPVFWGCGVTPQSVALDAKPDLMITHAPGHMFITDIPDSQLSD
What are the official names of this protein?
Putative hydro-lyase SSP0308.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: ADHC_MYCBO
Sequence: MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAIDIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANTRVAIIGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRKLRGGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDYINDAYERVLASDVRYRFVIDISAL
What are the official names of this protein?
NADP-dependent alcohol dehydrogenase C.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: LPLA_SALEP
Sequence: MTTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTHIVLAALNSLGVMADASGRNDLVVKTPDGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITSVRSRVANLTELLPGITHEQVCQAVTEAFFAHYGERVDAEVISPDKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDERFTWGGVELHFDVEKGVITRAQVFTDSLNPAPLEALGERLQGCQYRVDVLEQACESLIAEFPAQKGELRELAAWMAQAVR
What is the function of this protein?
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoate-protein ligase A, Lipoate--protein ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASNA_CLOPS
Sequence: MEKLFIPKDYKPLLSLRETEVAIKELKDFFEDSLAKNLNLTRVSAPLFVNKGSGLNDDLNGIERPVSFDMKAIPEFNIQIVHSLAKWKRLALHRYEFKHGEGLYTDMNAIRRDEDLDNIHSIYVDQWDWEKIIDKEERNLETLKETVRSIYSTFKATEDFIVSKYPHIEKILPEDITFITSQELEDRYPDLTSKERETAICKEFGAVFIIGIGGKLASGEKHDDRSPDYDDWTLNGDLLFYYPLFDEAVELSSMGIRVDEESLLKQLKIAECEERKELPFHQMLLEGKLPYTIGGGIGQSRICMFFLRKAHIGEVQASMWDEDMIRTCEENNIHLL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_CLOBL
Sequence: MRVKVTLACTECKRRNYNTMKNKKNDPDRLEMNKYCPHCHKHAAHKETK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: HOXN_CUPNH
Sequence: MFQLLAGVRMNSTGRPRAKIILLYALLIAFNIGAWLCALAAFRDHPVLLGTALLAYGLGLRHAVDADHLAAIDNVTRKLMQDGRRPITAGLWFSLGHSSVVVLASVLIAVMATTLQERLDAFHEVGSVIGTLASALFLFAIAAINLVILRSAYRAFRRVRRGGIYVEEDFDLLFGNRGFLARIFRPLFRFITRSWHMYPLGMLFALGFDTATEVALLGISTMEASRGVPIWSILVFPALFTAGMALIDTIDSILMCGAYAWAYAKPVRKLYYNMTITFVSAIVALIVGGIETLGLLADKFMLKGVFWNAVGALNENFCQLGFVIIGIFTVCWVVSIVVYRLRRYDDSEVRA
What is the function of this protein?
High-affinity nickel transporter responsible for nickel uptake.  Necessary for high levels of activity of hydrogenase and urease.  Does not transport cobalt.
What are the official names of this protein?
High-affinity nickel transport protein.
What is the protein family that this protein belongs to?
Belongs to the NiCoT transporter (TC 2.A.52) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IER1_SOLLC
Sequence: MEANKSMVKLVAFLIILVSSCFQSLTAQDLEIEVSDGLNVLQVHDVSQSFCPGVTKESWPELLGTPAKFAKQIIQKENPKLTNVETLLNGSAFTEDLRCNRVRLFVNLLDIVVQTPKVG
What are the official names of this protein?
Ethylene-responsive proteinase inhibitor 1, Ethylene-responsive proteinase inhibitor I.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I13 (potato type I serine protease inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9_ECOLC
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNIEFFEARRAELEAKLAEVLAAANARAEKINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTTGEHEVSFQVHSEVFAKVIVNVVAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: DOC_MYCS2
Sequence: MTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAWTFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAAQTG
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Upon overexpression causes bacteriostasis.  Its effect is neutralized by coexpression with cognate antitoxin PhD.  May bind the 30S ribosomal subunit.  In M. smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.
What are the official names of this protein?
Toxin Doc, Death on curing protein.
Protein: VIRBA_AGRFC
Sequence: MNDDNQQSAHDVDASGSLVSDTHHRRLSGAQKLIVGGVVLALSLSLIWLGGREKKENGDAPPSTMIATNTKPFHPAPIDVTLDPPAAQEAVQPTAPPPARSEPERHEPRPEETPIFAYTSGDQGTSKRVQQGETDRRREGNGEDSPLPKVEVSAENDLSIRMKPTELQPTRATLLPHPDFMVTEGTIIPCILQTAIDTSLAGYVKCVLPWDVRGTTNNVVLLDRGTTVVGEIQRGLQQGDARVFVLWDRAETPDHAMISLASPSADELGRSGLPGTVDNHFWQRFSGAMLLSVVQGAFQAASTYAGSSGGGTSFNSVQNNGEQTADTALKATINIPPTLKKNQGDTVSIFVARDLDFSGIYQLRMAGRAARGRDRRP
What is the function of this protein?
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
What are the official names of this protein?
Protein virB10.
What is the protein family that this protein belongs to?
Belongs to the TrbI/VirB10 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HMNL_RAT
Sequence: MAKRGFNCLLLSISEIDLPVKRLESPNKTRRPYGASIY
What is the function of this protein?
Plays a role as a neuroprotective factor (PubMed:12154011).  Protects against neuronal cell death induced by amyloid-beta peptides (PubMed:12154011).  Also protects against excitotoxic cell death (PubMed:12154011).  Prevents amyloid-beta peptide-induced spatial learning and memory impairments, protects against amyloid-beta peptide-induced suppression of hippocampal long-term potentiation, and inhibits amyloid-beta peptide-induced activation of STAT3 and inhibition of CASP3 (PubMed:23996574).  Prevents glutamate-induced dendritic atrophy in hippocampal neurons and also prevents glutamate-induced decrease in SYP puncta number and total puncta area (PubMed:31214013).  Protects anterior pituitary cells from TNF-induced apoptosis (PubMed:25360890).  Plays a role in ovarian follicle development by acting as a cryoprotective factor for granulosa cells in the antral follicle (PubMed:33764899).  Increases androgen production in Leydig cells and promotes Leydig cell survival by preventing apoptosis (PubMed:16619233).
What are the official names of this protein?
Humanin-like protein, HNr, Rattin.
What are the subcellular locations of this protein?
Mitochondrion. Secreted. Cytoplasm. Note=Detected in the cytoplasm of anterior pituitary cells.
Protein: IF6_MOUSE
Sequence: MAVRASFENNCEVGCFAKLTNAYCLVAIGGSENFYSVFEGELSDAIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDSLT
What is the function of this protein?
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm.  Behaves as a stimulatory translation initiation factor downstream insulin/growth factors.  Is also involved in ribosome biogenesis.  Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.  Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity.  In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR (PubMed:26383020).  Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (PubMed:26391622).  Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC).  Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).  Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (PubMed:21665150).
What are the official names of this protein?
Eukaryotic translation initiation factor 6, eIF-6, B4 integrin interactor, CAB, p27(BBP).
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Protein: RBFA_MYCS2
Sequence: MADPARAKRLAKRISTIVASAIEYEIKDPRLAGVTITDAKVSGDLHDATLYYTVLGASLDEDPDYEGAAAALEKAKGVLRTKVGAGTGVRFTPTLAFVRDTVPDAAHRMEELLARARAADEDLARVREGAKHAGDPDPYRVGGAEDTDGDTDGDER
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_STAAM
Sequence: MTKPIVAIVGRPNVGKSTIFNRIVGERVSIVEDTPGVTRDRIYSSGEWLTHDFNIIDTGGIEIGDAPFQTQIRAQAEIAIDEADVIIFMVNVREGLTQSDEMVAQILYKSKKPVVLAVNKVDNMEMRTDVYDFYSLGFGEPYPISGSHGLGLGDLLDAVVSHFGEEEEDPYDEDTIRLSIIGRPNVGKSSLVNAILGEDRVIVSNVAGTTRDAIDTEYSYDGQDYVLIDTAGMRKKGKVYESTEKYSVLRALKAIERSNVVLVVIDAEQGIIEQDKRVAGYAHEQGKAVVIVVNKWDTVEKDSKTMKKFEDEVRKEFQFLDYAQIAFVSAKERTRLRTLFPYINEASENHKKRVQSSTLNEVVTDAISMNPTPTDKGRRLNVFYATQVAIEPPTFVVFVNDVELMHFSYKRYLENQIRAAFGFEGTPIHIIARKRN
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: O16B_CONCN
Sequence: DECFSPGTFCGTKPGLCCSARCFSFFCISLEF
What is the function of this protein?
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process.  This toxin acts on Nav1. 4/SCN4A and Nav1. 6/SCN8A (EC(50)=2. 3 uM).
What are the official names of this protein?
Delta-conotoxin-like CnVIB, Delta-CnVIB.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS19_BUCBP
Sequence: MPRSLKKGPFIDIALLRKVEQAVEIRDKKPIRTWSRRSTIFPKMVGLTMLIHNGRQHIPVFITEDMVGHKLGEFVLTRTYRGHTADKKVKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.