PharMolix/UniProtQA huggingface dataset:
Protein: CEX_CONCN
Sequence: APWLVPSQITTCCGYNPGTMCPSCMCTNTC
What is the function of this protein?
May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential.  Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations.
What are the official names of this protein?
Conotoxin CcTx, Excitotoxin CcTx.
What are the subcellular locations of this protein?
Secreted.
Protein: METN_FRATT
Sequence: MIQIKNLKKEYRTNNTSNLVLDNINLEIKQGEIFGIIGHSGAGKSSLLRCLNLLEQPTDGSIFIADENITKKNSKQLREFRKKVAMIFQHFNLLSSRNVFENIALPLEIQGIPKSEIKKRVFELLDLVELPNKANAYPQELSGGQKQKVAIARALALNPLVLLSDEATSALDPTSTKQILALLKILNKELGLTIVLITHEMDVVRKICDRVAIIDKGRIAEMGKTLDVFLNPQAPVTRSFVETSIHTKVPDFIAKKLQDNPYSYDNTYPVVQLTFYGDKGKMPIIAEISRQFNATASIIQANIETIQDQIVGIAICHITGERQGWENALRFLSNQDVNLKVLGYATADNI
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DCD_BURMA
Sequence: MSIKSDKWIRRMAEEHKMIEPFVPDQVRAAEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: CALM3_RAT
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
What is the function of this protein?
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding.  Calcium-binding is required for the activation of calmodulin.  Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.  Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
What are the official names of this protein?
Calmodulin-3.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
Protein: ABC1_BPP22
Sequence: MRRLNITTAEMESVCGRMVACRAAEHLGLNINQFYYIAKKLSLKTAFIKPRWSDDEDKRMQTLISSGYTQRNVAKILGRSEESVKSRLSRLRKK
What is the function of this protein?
Modulates the activity of the host recBCD nuclease.  And thus protects linear double-stranded DNA from exonuclease degradation.
What are the official names of this protein?
Anti-RecBCD protein 1, Protein abc1.
Protein: Y4976_BACCQ
Sequence: MTENNDIKMVIITGMSGAGKTVALQSFEDLGYFCVDNLPPMLLPKFIELMADSKGKMNKVALGIDLRGREFFEHLWEALDDLSERTWIIPHILFLDAKDSTLVTRYKETRRSHPLAPTGLPLKGIEAERNLLTDMKARANIVLDTSDLKPKELREKIVHLFSTETEQAFRVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIPHMKPLTGLDEEVSSYVLKFNETHKFLEKLTDLITFMLPHYKREGKSQLVIAIGCTGGQHRSVTLTEYLGKHLKPEYSVHVSHRDVEKRKGH
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein BCQ_4976.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: PFF1_SORMK
Sequence: MINPISFRPGPVTFWTTLIYLALLIPIVIINEEPPAAPKTAEPFKGVNLTEAWLDLTTITRAYHPYNSKFNEEVRRYLLEKVESILEENGATWVFDDQMAAAAKDGKSAAVTVFDDNVSNSTFVMGKSNGTTFTRTESINNAAYFEGTNILVYIRGKEDDDGDWWEADYVHGMRRNAKGLTLVNAHYDSVSTGFGATDDGMGVVTCLQVLKYFTTPGNQPQRGIVVMLNNGEEDWLYGARALGQHKLNPFIHTFLNVEGAGAGGRAIVFRATDREVMAAYARTSHPFGTVIASDAFGMGFISSGTDYSVLVDAYGQRGIDLAFFKPRARYHTNQDDTRHASKESLWHILSASIHTTKQLSGDTGNTFIGQRPDKAHGKVANGRPSNGVWFDLFGKSFVLFGLRGMFAWSLTLLIATPLILVGITWLLRNLDKDYFFTSTVKTKEHPEYEAVPIGGWKGFFRWAMMVSIFYFSFWMIMRGANFVRPSALHRGYANLWLFVFGWIVLVAVTALEDRRRIAAGYIFVFLESAIFLSCLISFVELLALPRKSAYALQVQEDYDGHDHSGYQGYRDSTDGLSSGARAESSASAGSPSSPTVAQEPSKPTAPAGTTNGLSTAPSVAAHSSQPQPAPATPTPGRSTSAPIPSTTPRDEDESEDDDDEATERTPLVGGNGTNDRGRTTFATTYRRSITALVHGARKMEEDGEPYEHEQDWSGHLPSWAWFFQFLLLGPFMIILAAQTGLMLTDAVYQTGSDGSKLFTPYLMIFFFTLLLILPLTPFIHRVTHHIPVFLLVVFIVTLTYNLIAFPFSANNRYKAFFGQYIDVATGENKVCYTGIEEYVRPIIAELPSASGRDVTCGKSLRRGSTIATCCFDGSAVPPKLGSEDLDGLPQDNYADIITVNATRSHKKGDSSRTTARIEITADNTKSCFLQFKKPVSALTIESGSGWDDRFGQYPEDGVGLVRLWHREFDKTWVVNAEWKGSETRKGDDENDGTVICMWSDANTPGTIPALDEALQFVPSWAAVTKFSEGLVEGRKAFKIV
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: RIMP_ELUMP
Sequence: MRDIKAIESVVADGLANQGYEVVDLIVQNQGSKKLFQFFVDKEGGINLDDVEKASRLIDSIIEMENLIEGAYILEASSPGIKRVLKKPEHFKKFIGQRAKITLKQMIENRANFTGLIAGANETEMTLDDGTTQFKFKYEDIKKANLDPVLEF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMP2_RAT
Sequence: MLVILAFIIVFHIVSTALLFISTIDNAWWVGDGFSADIWRVCTNSTNCTEINDLSSTEEFSGYSVMQAVQATMILSTILSCISFLIFLLQLFRLKQGERFVLTAIIQLMSCLCVMIGASVYTDRRQDLHHQNSQLYYLLQEGSYGYSFILAWVAFAFTFISGLMYMILRKRK
What is the function of this protein?
Functions as a key regulator of cell membrane composition by regulating protein surface expression.  Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.  Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity).  Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (By similarity).  Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins (By similarity).  Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity).  Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (By similarity).  Also regulates many processes through PTK2 (By similarity).  Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (By similarity).  Regulates cell migration and cell contraction through PTK2 and SRC activation (By similarity).  Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (By similarity).  Positively regulates cell proliferation (By similarity).  Plays a role during cell death and cell blebbing.  Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (By similarity).  Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (By similarity).  Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity).  Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity).  May play a role in glomerular filtration (By similarity).
What are the official names of this protein?
Epithelial membrane protein 2, EMP-2.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane. Apical cell membrane. Membrane raft. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney (PubMed:24814193). Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane (By similarity).
Protein: RS12_KORVE
Sequence: MPTFNQLVRKGRTAPKFKTASPALQSCPQKRGVCTRVYTQTPKKPNSALRKVARVRLTNGIEVTTYIPGIGHNLQEHSIVLIRGGRVKDLPGVRYHVVRGTLDSVGVANRKQGRSKYGAKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: MRAZ_HISS2
Sequence: MFRGASAVNLDSKGRIAIPTRYRPEILEINQGQMVCTVDIRQPCLLLYPLNQWEIIEQKLSKLSNFNPEERSLQRVMLGYATECELDSAGRILISAPLRQHAKLEKSIMLVGQLNKFEIWSESEWQAQIEKDMTLGASGQFAMSEALSMLSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MNME_RICB8
Sequence: METIFAQSSSFGKAGVAVFRVSGTKSLEVLKLLTGKSNFKPRFMYYQKLTSPESNDLIDNAMVVYFKAPNSFTGEDVVEIHTHGSKAISIMLTNALLNIPGVRLAEAGEFTKRAFLNNKFDLTAAEGIADLINAETIMQHKQAIRQAGGALEELYNSWRSQLLRIISLLEAYIDFPDEDIPESVLKDVTNTHKTLINTISEYLNDNRKGELLRSGLKLAIIGPPNAGKSSLLNFLMRRDIAIVSNIAGTTRDIIEGHLDIGGYPIILQDTAGIRGESNDVIEQEGIKRAIDSAKKADIKIVMFDAETLDSAVNEDITGLIDENTIVIINKIDLIPENRIFNIENKYRCLKVSIKNNIALPSILKNIEEIAENMAGFTETPYITNERHRHHLKQALVYLKDFNLDNDLVLATEDIRMTMHRIGAITGIIDVEEILGEIFKNFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AHL2_ARATH
Sequence: METTGEVVKTTTGSDGGVTVVRSNAPSDFHMAPRSETSNTPPNSVAPPPPPPPQNSFTPSAAMDGFSSGPIKKRRGRPRKYGHDGAAVTLSPNPISSAAPTTSHVIDFSTTSEKRGKMKPATPTPSSFIRPKYQVENLGEWSPSSAAANFTPHIITVNAGEDVTKRIISFSQQGSLAICVLCANGVVSSVTLRQPDSSGGTLTYEGRFEILSLSGTFMPSDSDGTRSRTGGMSVSLASPDGRVVGGGVAGLLVAATPIQVVVGTFLGGTNQQEQTPKPHNHNFMSSPLMPTSSNVADHRTIRPMTSSLPISTWTPSFPSDSRHKHSHDFNITLT
What is the function of this protein?
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).
What are the official names of this protein?
AT-hook motif nuclear-localized protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRAH_PENCR
Sequence: MSVDAAVVKNEDKYIPTIDLRDYFDAYSEEKRAKVIEQVRKACLEHGFFQVEGHGVPVESQRRMFAACKALFDLPLEKKRRISLYKYSWRRGYEGPGEQQANDPHHGDFERDAKEGFFVGKELPLDQVDFGKGPNVWPPDLAENDFHRPVMEYYEHARKVGFKVMELLAVSLGHPPSILKDFTTDAAMFLKLLRYPAHTWTDTRKFGSGQHTDYGGITILLQDPGQDGLEVWHEATQQWVELPALEDKFVINLGDMVQRWTGGKYKSTLHRVINKTGGERYAVPAFWHGDLDAKNPLDPNDTSDETVLEFIKKKFYKGYGLTDDTSL
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase; part of the tra gene cluster that produces terrestric acid (PubMed:30811183).  The clavatol biosynthesis cluster cla and the terrestric acid cluster tra are both involved in the production of peniphenones and penilactones (PubMed:30811183).  The non-reducing PKS claF is responsible for the formation of clavatol from successive condensations of 3 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit, and 2 methylation steps (PubMed:30811183).  The esterase claE probably collaborates with claF by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (By similarity).  The clavatol oxidase claD then converts clavatol to hydroxyclavatol (PubMed:30811183).  Spontaneous dehydration of hydroxyclavatol leads to the accumulation of the highly active ortho-quinone methide (PubMed:30811183, PubMed:31860310).  On the other hand, the PKS-NRPS hybrid traA is involved in the formation of crustosic acid, with the help of traB and traD (PubMed:30811183).  The polyketide synthase module (PKS) of traA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 3 malonyl-CoA units (PubMed:30811183).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with L-malic acid (PubMed:30811183).  Because traA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase traG (By similarity).  Crustosic acid undergoes decarboxylation and isomerization to the terrestric acid, catalyzed by the 2-oxoglutarate-dependent dioxygenase traH (PubMed:30811183).  Both acids are further converted to the 2 gamma-butyrolactones (R)-5-methyltetronic acid and (S)-5-carboxylmethyltetronic acid, with involvement of the cytochrome P450 monooxygenase claJ (PubMed:30811183).  Spontaneous addition of the methide to these gamma-butyrolactones leads to peniphenone D and penilactone D, which undergo again stereospecific attacking by methide to give penilactones A and B (PubMed:30811183, PubMed:31860310).
What are the official names of this protein?
2-oxoglutarate-dependent dioxygenase traH, Terrestric acid biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: NURA_SACS2
Sequence: MIRKIYDKLVESHNEIKNQIYNIANYLKQEIQDKVNEYWNEYVINHEQSETCKFVAIDGGSFGRPMRIGIVYAVGAESVIGDNKGVKTLSEDGQIGIFKPGNDAQERISLLMEALELSLALRDGSKGDYILMDGSLSKKIGNKVDIQQFSDEELKLIRNVDLNGIISIKDERKMRDLLMLLNQFLVSKIIEEYDGNVLWISKVSRGRDLFGTDYPDITVLELFTEKRGFSKLIIKNIDIEKISEIPEIEVLRKMEYTTFYTRLDNGKRVIRVDIVGRVDEKIVKEIMDRLSGVSIKGYPFPLLKAHMDVRFSAMDREKIIKLVGSKLHKDIEWWPSQFY
What is the function of this protein?
Involved in DNA double-strand break (DSB) repair (PubMed:22135300).  Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity).  Processes linear dsDNA probes with 3' or 5' single-stranded overhangs or blunt ends (PubMed:22135300).
What are the official names of this protein?
DNA double-strand break repair nuclease NurA.
What is the protein family that this protein belongs to?
Belongs to the NurA family.
Protein: GBGE_CALVI
Sequence: MDPSALQNMDRDALKKQIENMKYQANMERWPLSKSIAEMRSFVEENEKNDPLINAPDKKNNPWAEKGKCVIM
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  This subunit functions in visual transduction in the compound eye.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit gamma-e.
What is the protein family that this protein belongs to?
Belongs to the G protein gamma family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: PURT_SYNC1
Sequence: MIGTPLKKSATKLMMLGCGELGKEVVIEAQRFGIETIAVDRYADAPAMQVAHRSHVANMLDRDALERIIKQESPDLIVPEIEAINTTFLLELEQQGFRIIPTARATNLTMNREGIRRLAAEDLNLPTAAYRFASSYEEFCQAVEEIGLPCVIKPIMSSSGKGQSTVKTPDDIEKAWNYARQGARGAGERVIIEAFIPFDYEITLLTVRHVDGTSYCPPIGHRQEGGDYQESWQPMPMTDKALAEAQRQAKVITEALGGAGLFGVEFFIQGDTVYFSEVSPRPHDTGMVTMATQNMSEFELHVRAVLGLPIPAIELLSPGASHVVLAGGQDDEVSFSGVEDALRVPGSKVRLFGKPDSRPGRRMGVALVVAPDVDTARKRAEEAAGKIRVEPVK
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: QUEF_RALSO
Sequence: MSHPEHSPLGKASAYKTQYDPSLLFPIPRQAKRDEIGLAAGSALPFFGIDLWNLYELSWLNLKGKPQVAIGTVIVPADSPNIVESKSFKLYLNTFNQTKVASSEALQQLIHHDLSEACGAPVQVRIVPQEEFARQKMGELAGLSLDRLDVETDVYQPTPGLLHADQDESPVEEVLVSHLLKSNCLVTGQPDWGSVQIRYVGAPINQEGLLKYLISFREHNEFHEQCVERIFMDIQRQCRPVKLAVYARYTRRGGLDINPFRTNFNTPWPDNLRNARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCAFB_BPS13
Sequence: MEQLTKNQAVATSQEAFQNQNEPQLRDENVHNDKSVHGVLNPTYQAGLRRDAVQPDIEAERKKRDEIEAGKSYCSRRFGGATCDDKSAQIYARFDKNDWRIQPAEFYRFHDAEVNTFGYF
What is the function of this protein?
Participates in the assembly of the viral procapsid in the cytoplasm.  Forms first a 12S pre-assembly complex with protein H, and F and G pentamers, then twelve 12S complexes are joined by the D protein to form the procapsid.  Internal scaffold protein B is released from the procapsid upon genome packaging.  Autoproteolytic activity cleaves protein B and probably facilitates its removal through the pores of the procapsid.
What are the official names of this protein?
Internal scaffolding protein B, Scaffolding protein B, GPB.
What is the protein family that this protein belongs to?
Belongs to the microviridae B protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: SECM_SALTI
Sequence: MSGILTRWRQLGRRYFWPHLLLGMVAASFGLPALSNAAETNTPARTTASTASKVNFSHLALLEASNRRPNFTVDYWHQHAIRTVIRHLSFAMAPQTLPVADAPSPLQAHHIALLNTLSAMLTQEGTPPAIVRRLSLAYFAPQTAFSIPAWISQAQGIRAGPQRLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: NS6_BC279
Sequence: MFHLVDFQVTIAEILIIIMKTFRVAIWNLDILISSIVRQLFKPLTKKKYSELDDEEPMELDYP
What is the function of this protein?
Could be a determinant of virus virulence.  Seems to stimulate cellular DNA synthesis in vitro (By similarity).
What are the official names of this protein?
ORF6 protein, ORF6, Accessory protein 6, Non-structural protein 6, ns6.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses accessory protein 6 family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane. Host Golgi apparatus membrane.
Protein: GNL3_CAEEL
Sequence: MAKYCLKKTSKRVSCAKRYKIEKKVRDHNRKVKKEAKKNGTTNKKEKTISVPNSCPFKEEILVQAEQEREKIKVRQEAAKEAAKIHRIEKRKNNLPANFESMVAKASKQGTEFDKKVASAAEHEKFNTLDDKTIKAYASEVRKTVEIADVIIQVLDARDPLGSRSKSVEDQVLKGGKRLVLLLNKIDLVPRENVQKWLEYLRGQFPTIAFKASTQEQKSNIGRFNSAILNNTETSKCVGADIVMKILANYCRNKDIKTSIRVGVVGFPNVGKSSVINSLKRRKACNVGNLPGITKEIQEVELDKNIRLIDSPGVILVSQKDLDPIEVALKNAIRVDNLLDPIAPVHAILRRCSKETIMLHYNLADFNSVDQFLAQLARRIGKLRRGARPDVNAAAKRVLNDWNTGKLRYYTHPPEQGTAKEDIVVPAEVVSQFSKEFDIDAIAEEQNQIVEGLPMESDIIAPHNSDEEEDDDDEMETDVNEKKQTVTSGRKVKGPTKDDDKPVLPESLALEGNVQLNKLIKTAIKKQKKKSKKTANRADKLSDSLGNMLGGDAMEM
What is the function of this protein?
May play a role in regulating cellular proliferation in both germline and somatic tissues.
What are the official names of this protein?
Guanine nucleotide-binding protein-like 3 homolog, Nucleostemin-1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LGT_PROMT
Sequence: MEHIFLALRSPGPELFQLGPFSLRWYGLLIAISVLVGLNLSSELASKKGLKKSLINDLLPILVLASVIGARIYYVAFEWRNYTGKNFWSSINFLNLNIPIPSALEIWGGGIAIHGALIMGTLSIIFFCRWRQEHFWDVIDVLVPSVALGQAIGRWGNFFNNEAFGIPTNLPWKLFIPYRFRPEIFSTIDYFHPTFLYESVWNIFVFGILIFLFRKANKKDLKLPPGSLSCLYLITYSLGRFWIEGLRTDPLCLGGVPPFCEGGLRIAQLISLFLISAGLLGIWRIYVSKKALPDPSSMNGRNQ
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THIC_SALHS
Sequence: MSTTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSKDNPQFEENEAVPVYDTSGPYGDPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRERLADDGLDDLRFTGLLTPKRAKAGKRVTQLHYARKGIVTPEMEFIAIRENMGRERIRSEVLRHQHPGMSFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLLEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGSIQDANDEAQFSELHTLGELTKIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPFTARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAAAQTIEVGMADMSENFRAKGGEIYLKREEA
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.