PharMolix/UniProtQA huggingface dataset:
Protein: FAA30_MYCMM
Sequence: MSLISKLRELAEVKPDHEAFVFTEYDTRSGDRTSTLTWRQVYVRASNLARYLNSLNDDLERQKFAAICAPQGIEYIVGFLGALFAGWCPVPLPEPQGGLQDKRTGLALLDCSAAVVLTTAKDEDAVRATLAAYSLAVTTPVIALDTFEVADVSPSGAGDVSDFRPPEGGMYLQYTSGSTGNPRGARISLENVEINFRQIAKAAFPYKGTEVSLPRSTVSWLPLYHDMGLMVGLFIPVYCACPSYFMSPAAFVRKPIRWMRMLAERDQPFTAAPNFAFDLATSRISDADMSGIDLAHVSAISNGGERVQPNTVDSFLERFSRYGLRPEVVKPSYGMAEAVVYVAISEVGTPPVSTEFDAQSLANGHAELKGPDAEHATRLVRYHKLDADPLVRIVDPESCVELSPGGIGEIWVHGGNLSSGYHNVDNALNKEKFHATIRDKSPGTPRSPWLRTGDLGFEWDGGFYIVGRSKDLIIQDGVNHYPDDIENTVKEFTRGRVAAFSIADERSERLVIVAEVKPTGPASGSSGVELPLVKKRAMAALSRLHGLHVADFLFVPPQALPKTTSGKISRSACAKRYLSAGFEQLEVPQ
What is the function of this protein?
Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to a multifunctional polyketide synthase (PKS) for further chain extension.
What are the official names of this protein?
Probable long-chain-fatty-acid--AMP ligase FadD30, FAAL, Acyl-AMP synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: M1I1A_DANRE
Sequence: MQMSEPLSQKNALYTAMNRFLGAVNNMDQTVMVPSLLRDVPLDQEKEQQKLTNDPGSYLREAEADMYSYYSQLKSIRNNIEWGVIRSEDQRRKKDTSASEPVRTEEESDMDLEQLLQFHLKGLHGVLSQLTSQANNLTNRYKQEIGISGWGQ
What is the function of this protein?
Involved in stabilization of microtubules.  May play a role in the regulation of lipogenesis (By similarity).
What are the official names of this protein?
Mid1-interacting protein 1A, Gastrulation-specific protein G12.
What is the protein family that this protein belongs to?
Belongs to the SPOT14 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Protein: IAA2_WHEAT
Sequence: MWMKTVFWGLLVFMLVATTMAVEYGARSHNSGPWSWCNPATGYKVSALTGCRAMVKLQCVGSQVPEAVLRDCCQQLADINNEWCRCGDLSSMLRSVYQELGVREGKEVLPGCRKEVMKLTAASVPEVCKVPIPNPSGDRAGVCYGDWAAYPDV
What is the function of this protein?
Alpha-amylase inhibitor.
What are the official names of this protein?
Alpha-amylase inhibitor 0.28, CIII, WMAI-1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GUAA_XANAC
Sequence: MTNIHTDKILILDFGAQYTQLIARRIREIGVYCEIWAWDHDPSEIAGFGAKGIILSGGPESTTLPGAPVAPQEVFDSGLPVFGICYGMQTLAAQLGGATEAADQREFGHAEVDVVAADALFAGLTDHAGASRLNVWMSHGDHVSQVPPGFTITATTDRIPVAAMSNEAKRWYGVQFHPEVTHTLQGQTLLRRFVVDVCGCQTLWTAANIIEDQIARVREQVGDDEVILGLSGGVDSSVVAALLHKAIGDKLTCVFVDTGLLRWQEGDQVMAMFAEHMGVKVIRVNAADRYFAKLEGVRDPEAKRKIIGNLFVEIFDEESNKLANAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEHMKLGLVEPLRELFKDEVRRLGVELGLPRTMVYRHPFPGPGLGVRILGEVKREYAELLAKADAIFIDELRKADLYDTTSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETIDFMTAHWAHLPYDFLGTVSNRIINELRGVSRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: DNLI1_HALWD
Sequence: MKYSELAEVYTDVAATSATTQKETLLADCFLDVYDNTETSLLPVTVRLVRGRVFARWEAAEIGVSTAGAADAISKATGVESEQIETWWREEGDLGDAAAYAVDDRVQQTLTATPLTVTRVYETLREVASYEGSGSQQKQRDEIAGLISDASPLAARYIVRTVTGSMRLGVGEGIVRNALASAFLDMSDDAADAVQRAIDLTNDVAVVAQRVAEQGQPGLDDVDLELFRPIKPMLAKQAESIQTAVDELAADPKHIERNHNIELSHSGAVLIEFKYDGIRAKIHRDGDDIRVYTRRLSDVTEQFPDVVSAARDHIDAKHYIIEAELVGYDPQSNDDTPVTFQTLAQRIQRTDNVATIAKSIPVTTYVFDLLALNGESLLTDTLEMRLERLNTILSTKATSDSKSASTHNAHSSTSVTTVSSDQYQSSSSLRRAQCTWATTQTTAAEFYEDALAAGHEGVMIKNPARPYQPGSRVGYQRKIKPTMEPLDLVVTRAKWSEGRKSDFLGRPYLACRTADGNLAEVGRMHTGFTDDQLETFTNRVEPLIENVEGREATLTPAVVLAVEYEEIQISSTYDSGYALRFPRLKQIRHDCDPSQADSLERVERLYEQQSLDESQTSV
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase 1, Polydeoxyribonucleotide synthase [ATP] 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: SOR_PYRAB
Sequence: MLKDTIKSGDWKGEKHVPVIEYEKEGDLVKVEVSVGKEIPHPNTPEHHIAWIELYFHPEDGQFPILVGRVAFTSHDDPLTEPRAVFFFKTKKKGKLYALSYCNIHGLWENEVQLE
What is the function of this protein?
Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.
What are the official names of this protein?
Superoxide reductase, SOR.
What is the protein family that this protein belongs to?
Belongs to the desulfoferrodoxin family.
Protein: RLMN_ECOLC
Sequence: MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_STAAW
Sequence: MYNGILPVYKERGLTSHDVVFKLRKILKTKKIGHTGTLDPEVAGVLPVCIGNATRVSDYVMDMGKAYEATVSIGRSTTTEDQTGDTLETKGVHSADFNKDDIDRLLESFKGIIEQIPPMYSSVKVNGKKLYEYARNNETVERPKRKVNIKDIGRISELDFKENECHFKIRVICGKGTYIRTLATDIGVKLGFPAHMSKLTRIESGGFVLKDSLTLEQIKELHEQDSLQNKLFPLEYGLKGLPSIKIKDSHIKKRILNGQKFNKNEFDNKIKDQIVFIDGDSEKVLAIYMVHPTKESEIKPKKVFN
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: CAV2_GORGO
Sequence: MGLETEKADVQLFMDDDSYSHHSGLEYADPEKFADSGQDRDPHRLNSHLKLGFEDVIAEPVTTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGILFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVIIAPLCTSVGRCFSSVSLQLSQD
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Interacts directly with G-protein alpha subunits and can functionally regulate their activity.  Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.  The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells.  Positive regulator of cellular mitogenesis of the MAPK signaling pathway.  Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
What are the official names of this protein?
Caveolin-2.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
Protein: RF1_VARPS
Sequence: MKTFLRHQLERYAQRLGELDFLLSREDIMSDMAQYRTISREHAEITQIAGRYERYKQREADIAGAAEMLEDPDMAEMAREEIAAAQAELVQLEEELQRLLLPKDPDDARNAFLEIRAGTGGDESALFAGDLLRMYTRYCERAGWRCEVVSESESELGGYKEVVIRIAGNDVFGRLRFESGGHRVQRVPATETQGRIHTSACTVAVLAEPDETVAVQINPADLRIDTYRASGAGGQHINKTDSAVRITHIPTGIVAECQDDRSQHRNKAKALQVLSARIQEKDRSERAAKDAAMRKGLIGSGDRSDRIRTYNFPQGRLTDHRINLTLYKLQAIMEGDLGDVLDALRAAREAEQLAELESSLPA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFA2_MOUSE
Sequence: MWNSGFESFTSSTYGGRGGYTQSPGGFGSPTPSQAEKKSRVRAQHIVPCTISQLLSATLTDEVFRIGDVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAPPMDVRQWVDTDDASGENAVVPPETYVKVAGHLRSFQNKKSLVAFKIIPLEDMNEFTAHILEVVNSHMMLSKPNSQASAGRPSMSNPGMSESFNFSGNNFMPANRLTVVQNQVLNLIKACPRPEGLNFQDLRSQLQHMPVPSIKQAVDFLCNEGHIYSTVDDDHFKSTDAE
What is the function of this protein?
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress.  It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism.  Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.  In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation.  Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response.  It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage.  Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair.  Also plays a role in base excision repair (BER) probably through interaction with UNG.  Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage.  May also play a role in telomere maintenance.
What are the official names of this protein?
Replication protein A 32 kDa subunit, RP-A p32, Replication factor A protein 2, RF-A protein 2, Replication protein A 34 kDa subunit, RP-A p34.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Protein: AOX_NEUCR
Sequence: MNTPKVNILHAPGQAAQLSRALISTCHTRPLLLAGSRVATSLHPTQTNLSSPSPRNFSTTSVTRLKDFFPAKETAYIRQTPPAWPHHGWTEEEMTSVVPEHRKPETVGDWLAWKLVRICRWATDIATGIRPEQQVDKHHPTTATSADKPLTEAQWLVRFIFLESIAGVPGMVAGMLRHLHSLRRLKRDNGWIETLLEESYNERMHLLTFMKMCEPGLLMKTLILGAQGVFFNAMFLSYLISPKITHRFVGYLEEEAVHTYTRCIREIEEGHLPKWSDEKFEIPEMAVRYWRMPEGKRTMKDLIHYIRADEAVHRGVNHTLSNLDQKEDPNPFVSDYKEGEGGRRPVNPALKPTGFERAEVIG
What is the function of this protein?
Catalyzes cyanide-resistant oxygen consumption.  May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
What are the official names of this protein?
Alternative oxidase, mitochondrial, ALTOX.
What is the protein family that this protein belongs to?
Belongs to the alternative oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Protein: CYB_MONMN
Sequence: MTNIRKTHPLAKIINNSLIDLPAPSNISAWWNFGSLLGICLILQILTGLFLAMHYTPDTTTAFSSVAHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFTETWNIGIILLLTIMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFILPFMVSALVAVHLLFLHETGSNNPSGIPSNSDKIPFHPYYTIKDILGALLLIMILLLLALFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALMLSILILAIIPLLHTSKQRGMMFRPISQCLFWLLVADLLTLTWIGGQPVEHPYIIIGQLASILYFTILLVLMPIISIIENSILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MYO1C_BOVIN
Sequence: MALQVELIPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNTHFAADEESNAQVTTENQLKYLTRLLGVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVAKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTIKQHPHFLTHKLADQRTRKSLDRGEFRLLHYAGEVTYNVTGFLDKNNDLLFRNLKETMCSSENPILGQCFDRSELSDKKRPETVATQFKMSLLELVEILKSKEPAYVRCIKPNDSKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWTGRPQDGVTVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEIRRQSLATKIQATWRGFHCRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIQGFILRHAPRCPENAFFVDHVRTSFLLNLRRQLPRNILDTSWPTPPPALREASELLRELCRKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGADEINPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRIEYTNLTGISVSSLSDSLFVLHVQREDNKQKGDVVLQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGIIDFTPGSELLITKAKNGHLAVVAPRLNSR
What is the function of this protein?
Isoform 3 is involved in regulation of transcription.  Associated with transcriptional active ribosomal genes.  Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription.  Necessary for the formation of the first phosphodiester bond during transcription initiation.
What are the official names of this protein?
Unconventional myosin-Ic, Myosin I beta, MMI-beta, MMIb.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Cytoplasmic vesicle. Cell projection, stereocilium membrane. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 at actin-based membranes. Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus, nuclear pore complex. Note=In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity).
Protein: O56A1_HUMAN
Sequence: MIQPMASPSNSSTVPVSEFLLICFPNFQSWQHWLSLPLSLLFLLAMGANTTLLITIQLEASLHQPLYYLLSLLSLLDIVLCLTVIPKVLAIFWYDLRSISFPACFLQMFIMNSFLPMESCTFMVMAYDRYVAICHPLRYPSIITNQFVAKASVFIVVRNALLTAPIPILTSLLHYCGENVIENCICANLSVSRLSCDNFTLNRIYQFVAGWTLLGSDLFLIFLSYTFILRAVLRFKAEGAAVKALSTCGSHFILILFFSTILLVVVLTNVARKKVPMDILILLNVLHHLIPPALNPIVYGVRTKEIKQGIQKLLQRGR
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 56A1, Olfactory receptor OR11-75.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPB_OENPA
Sequence: MRINPTTSGPGVSTLEKKKSGRIAQIIGPVLDVTFPPGKMPNIYNALVVKGRDTGGQEINVTCEVQQLLGNNRVRAVAMSATDGLTRGMEVIDTGAPLSVPVGGATLGRIFNVLGEPVDELGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQNVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKAGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGDEHYETAQRVKETLQRYKELQDIISILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFKLILSGELDGLPEQAFYLVGTIDEATAKAANLEMESDLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: TSAD_MICAN
Sequence: MTIILAIETSCDETAVAIVNNNLVLSSVVSSQIDLHRLYGGVVPEMASRQHLETINFCLEKAWQETGLNWSEIDGIAATVAPGLVGALMVGMTAAKTLAIVHDKPFIGIHHLEGHIYASYLAESDLKPPFLSLLVSGGHTSLIHVQACGKYQQLGTTRDDAAGEAFDKVARLLNLSYPGGPIIDRMAKDGNPQAFPLPEGKISLPTGGFHAYDSSFSGLKTAVLRLVEKFEPDNLPVADIAASFQDTVARSLTRRTINCALDYGLKTIAIGGGVAANSALRNHLETAAKNHHLTVYFPPLKLCTDNAAMIARAAVDHYDLGHFSDLSIGVRSRLPLSEVMQLYK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE6_HPV69
Sequence: MFQDPRERPRTIHELCEALNTPLQSLQVQCVYCKKTLEWADVYNFAICDLRIVYRNDSAYGACKKCIIFYSKIIEYRRYTSSVYGATLEARPKRSLCNLLIRCHRCQIPLGPEEKQRIVDEKRRFHEIAGYWKGLCTNCWRPRREATETQV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: COAE_CAUVC
Sequence: MLILGLTGSIGMGKSTTSKMFQDEGVPVYDADAAVHALYASGGAAVAPVETAFPGVVVDGAIDRAKLSAQVVGNSEALAKLEAIVHPLVGAHRIGFFEQAKAEGHEIVVLDIPLLFETGGEKRVDKVVVVSAPAEVQRERVLARPEMTPEKFEAILARQTPDADKRARADFVIDTGQGLDHARRQVRDLLTLLRTARSA
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_BRUAB
Sequence: MPTVNQLIRKPRTAPVKRNKVPALQANPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: YVRJ_BACSU
Sequence: MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFYRFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIELMTELKDHAKK
What are the official names of this protein?
Uncharacterized protein YvrJ.
Protein: GLPE_ECOL6
Sequence: MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAVQAFHLTNDTLGAFMRDNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_ANTSP
Sequence: MITRKTLSLNFLKPVLELEYQIDQLSKMTYKNKSLNIHDLTALKKQLIKIKIEIFQSLTPLQRLHLVRQVDRPTTLDYIGHILDDWIELHGDRGGTDDPALIGGLGKINNRTVVCIGHQRGKDTKDNVLRNFGMASPGGYRKALRLMKHANRFNFPILTFIDTPGAWAGVDAERLGQGEAIAVNLREMFSFNVPIICTIIGEGGSGGALGIGVGDKVLMLEDAVYTVATPEACAAILWKDSKQSLEAAEALKITSYDLKALGIIDDIVEEPLGGSQEDSLLASHILHSKLVTELNYLLSLSSDKLKELRIPKIRRMGTFYEG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HPR_LYSSC
Sequence: MVLSEELYTQKEAMLYSQRIAQLSKALWKAVEKDWQQWIKPYDLNINEHHILWISYHLKGASISDVAKFGVMHVSTAFNFSKKLEERGFLKFSKRDDDKRNTYVELTEAGTELIVEMNKNYHNTYHSVLEGSLALKDLYGRFPDFLDVMAVIRNIYGEDFIDIFERSFQHFRDSFDTLEERPTVKG
What is the function of this protein?
Negative regulator of protease production and sporulation.
What are the official names of this protein?
HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.