PharMolix/UniProtQA huggingface dataset:
Protein: TRI34_HUMAN
Sequence: MASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYNYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPYFNPWNCPAPMTLCPPSS
What is the function of this protein?
Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853).  Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853).  During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966).  In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966).  Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709).  Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM34, Interferon-responsive finger protein 1, RING finger protein 21.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDOX_BACC0
Sequence: MIIVTNTAKITKGNGHKLIDRFNKVGQVETMPGFLGLEVLLTQNTVDYDEVTISTRWNAKEDFQGWTKSPAFKAAHSHQGGMPDYILDNKISYYDVKVVRMPMAAAQ
What is the function of this protein?
Allows bacterial pathogens to use the host heme as an iron source.  Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
What are the official names of this protein?
Heme-degrading monooxygenase, Heme oxygenase, Iron-regulated surface determinant, Iron-responsive surface determinant.
What is the protein family that this protein belongs to?
Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCSA_SYNS9
Sequence: MLNAPFELVTSLGFAAFVLLLIALPIAFWSVSSDSRPGVVRLLVAVANLLLTAQLVLRWWQSGHFPISNLYESLCFLAWACTLTQLLVERAWPSPIVAAAATPMGLGCIAFASFALPDQLQSAAPLVPALRSSWLVMHVSVIMVSYAALLVGSLLSLAVLVMDRGEALQLRSSSIGSGGFRQAVTTPDSGFLELQSLEISTNEQLDSLSYRTITVGFLMLTVGIISGAVWANEAWGSYWSWDPKETWALICWLVYAAYLHTRLSRGWQGRRPALVAVVGLIVIAVCYIGVNLLGIGLHSYGWFF
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: MATA1_PICAN
Sequence: MQFTILNEPSLDSQRREGDLASENYVFGDIRKEGVRILEDSLRSERNALLAIGAGGAADRVKQHYRKLLDDWEAAIMEIRSNDKYESLCCGFAIEKAEVETEMRNTEELDVYKECLVSECFDKKKRRHIPESSKELLEKAFKVKRFPNSKERERIARECGISPLQVRVWFTNKRARSKSRA
What is the function of this protein?
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion.
What are the official names of this protein?
Mating-type protein A1, MATa1 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the MATA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OL507_MOUSE
Sequence: MGILKDGNHTAVTEFILLGLTDDPVLKVVLFTIILCIYLVTVSGNLSTILLIRVSSQLHHPMYFFLSHLASVDIGISSSVTPNMLVNFLLERSTISYLGCGIQLGSGAFFGSTESFLLAAMAYDHFMAICNPLLYSTKMSTQVCIQLLVGSYIGGFLNASSFILSFFSFLFCGPNKVNHFFCDFTPLVELSCSDNSVLLILDSFSAGSIIVITVLVIAISYTYILITILKMHSTEGRHKAFSTCTSHLTAVTVFYGTVTFIYVMPKSSYSTDQNKVLSVFYMIAIAIPMLNPLIYSLRNNEIKNALKRQLSKKTFS
What is the function of this protein?
Potential odorant receptor.
What are the official names of this protein?
Olfactory receptor 507, Olfactory receptor 204-7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FGDH_CAEEL
Sequence: MKYDMNHRKNSDDTPPASRTVKEMMAEFQNKLDDGDNRFRKQPPPPPSPRRAPPPPPHRKPASLSPPPDDENTIRPPSSSESSENIPEEPQELITPNTTRRSLGPKPTVAPKPLFLNGLLPSSSTSDVSSQNSPKCDPHPSCTTPTILVSPATSEYSNGVFFGANETNGSGVKDRARQLVNMGFVPRMQNGGTGTPSERPISQVSTLSQVSDEFDEGDTSASDEESMNSEKHLRRHRHEDDFDELPLPKNERKTTTVAATHSEIMNEMEHLFVRGGKKNNGVHKQQRRQSNIDEIPSDVGKLRDNRKGRHNSLFVSPTSGMSSSSTDDFSRITSMTSDRSSILTSHSGGEDSTDGASPVPDYETGDEKDDQRLKKLHYAAVEFLKVQNNYVQYLKEMAVLYPEYMERFGKRVGRDLLASHNGHENVVLQIKKIMVQILPIHEMLLKEIDKVCSNWDSRYPNMSKTIGTFADFLKCCQPFLDNKADFLNKLLQLRNEDKEFDEATYMFETEVFKRGKKGAVIQQLDQVHQNFMRYKLLMLRYSEYLIDDCDEKEKAQEAIQKLENVTQAVNQKMGLPTTEELTKLYYRFQCQFNVLEPGRVLIRQSEVMKQTRKELQPRYLVLFTDYLWICRVSSSGQFDINRSYRIPLEYMKFERMEEDERIRCLQIRSRVKSALIIFSSEKERNQWTDDLTKAQYDRKSYKRRQSTAVQRHDENKKKMNKLLMLTPEVPDASDLERPQLIDSRSRSMSCESQDELSSVPVTPLDNGEIDETLGFGEVTRNGSGKKPPSEMIKPVWLPDNISNECLMEGCSTEFNIINRRHHCRDCGWLICKFCKGQAPLSKYDFTKQNVCSECFDRHYKAYKDGVLFPSKNMIVQSDETILVKIGKRNDKEIVDPRKLFKAPVNYGFRHRNVEEKRAQSIVFGRVYLSFRSRKTETVRHALLRRDDLKLVFYKAELDSKSVLELLIYGYFYRETPLDDGWLFELVHRNQIRTDDTKDDVISFRVDNSASAKKWSAAFADKLELDPTRG
What is the function of this protein?
Activates cdc-42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP (By similarity).  May play a role in regulating the actin cytoskeleton and cell shape (By similarity).  Required for normal lifespan (PubMed:36173858).
What are the official names of this protein?
FYVE, RhoGEF and PH domain-containing protein tag-77.
Protein: TAL_BRAHW
Sequence: MKFFIDTANVDEIKKANDMGVICGVTTNPSLIAKEGRDFKKTIEEITTIVDGPISGEVKATTVKAEDMIAEAREIAKIHKNMVVKIPMTVEGLKAVKVLSKEGIKTNVTLIFSANQALLAARAGATYVSPFIGRLDDISMDGLELIRTISEIFATHAIETEIISASVRHPIHVTECALAGADIATVPYSVIEQMTKHPLTDQGIEKFKKDYEAVFGK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGR_ECOLC
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVAALQEQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKDLYEAILELFDQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL10_CHICK
Sequence: MQTCCQALLLLLAACTLPAHCLEPTCLHFSELLPARLRELRVKFEEIKDYFQSRDDELNIQLLSSELLDEFKGTFGCQSVSEMLRFYTDEVLPRAMQTSTSHQQSMGDLGNMLLGLKATMRRCHRFFTCEKRSKAIKQIKETFEKMDENGIYKAMGEFDIFINYIEEYLLMRRRK
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRH_RUEST
Sequence: MPQSPEQPDVSSTVSYNRVMLKISGEALMGTQGFGLHPPTVRRIAEEVKSVHDLGVEICMVIGGGNIFRGLSGSAQGMERTTADYMGMLATVMNALGMQSALEDLGVFTRVISAIRMDEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMNCEAIFMGKNGVDGVYDKDPKTNEDAKRYDSVSYDDVLAKRLKVMDASAIALARDNNLPLIVFGLDEPGGFRGVLAGEGTYTKVHG
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WIT2_ARATH
Sequence: MEEIIREDYFEALSSRNEEEQEMLRMLTKLEIDSAYTSEKLMNLHVLLMHLLAWDNDLEGMGTLDSSPASFEKALTFDLLCGILESEVKEVDEVLDVLEAQIVDTSYKISSCKHGNYIVIEGKLGESAESLKQSRGQVSEITLQLAQLRRTLHYIRNGTSENEESVELRQKYALKPSDLRHKNALRMLEKSLSRELELEKKLMEFQQNEEQLKLKLHYTEEVSSRMEEASEFIWGRFLEADNSSEVLTGISKELVGRLQILQFSLNGSAQRESELKSKLEDCTVQLEAKDLLVQKLEGTISENSEIVSEVLTLREYVKSAEQKLKNTDLELKSVNASKQEILVHLAEMENANESVKENLFEAESRAESGEAKIKELDAANLELTEELNFLKDADDKKTKKVNSLEKQVRELEVQVQNSKVSSEANQEQQNMLYSAIWDMETLIEDLKSKASKAESRTETVEEQCIVLSTTNSELNKDVSFLRQKAKSLEAMLDLANNEKERYAQEITTRNKVLMDMMLQLSSERERIQEQLYSLAKENKILRVNQCSNTYQRNGSYAGDKELSFHADGHEIEALAESLQEDERTREEPEKQSVSEKSSEIRRAIKLKHILVVALVFVLFCSFFGVTY
What is the function of this protein?
Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips (PubMed:18591351).  Plays a role in nuclear shape determination (PubMed:25759303).  As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303).
What are the official names of this protein?
WPP domain-interacting tail-anchored protein 2.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: OPSD_CANLF
Sequence: MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNVEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFAIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSDFGPIFMTLPAFFAKSSSIYNPVIYIMMNKQFRNCMITTLCCGKNPLGDDEASASASKTETSQVAPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Required for photoreceptor cell viability after birth (PubMed:11972042).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: GLND_BURPS
Sequence: MSASVAEPPPALSRKAEFKAAKAELLARFKSANHVTPLMHALSRATDDALRSLWQECGLPATLALVAVGGFGRGELSPHSDVDILVLLPDAHASELDERIERFIGMAWDLGLEIGSSVRTVGQCIEEASHDVTVQTSLLEARRIVGSTALFERFMLRYREALDARAFFQAKVLEMRQRHAKFQDTPYSLEPNVKESPGGLRDLQTILWIARAAGFGSSWRELDTRGLITDREARELRRNEGFLKTLRARLHVIAGRRQDILVFDLQTQAAESFGYQPTSAKRASEQLMRRYYWAAKAVTQLATILIQNIEAQLFPATSGVTRVLSPGRFVEKQGMLEIAADDVFERHPDAILEAFLLYEATRGVKGLSARTLRALYNSRDVMNNAWRRDPRNRRTFMQILQQPEGITHAFRLMNQTSVLGRYLLNFRRIVGQMQHDLYHVYTVDQHILMVLRNIRRFAVAEHAHEYPFCSQLIVNFERPWVLYVAALFHDIAKGRGGDHSALGMADARRFCREHGIEGDDAALVVWLVQHHLTMSQVAQKQDTSDPVVIKRFAELVGSERRLTALYLLTVADIRGTSPKVWNTWKGKLLEDLYRATLAVLGGAQPDAHSELKTRQEEALALLRLETVPPDAHRALWDQLDVGYFLRHDAADIAWQTRVLYRHVAADTAIVRARPSPVGDALQVLVYVKDRSDLFAGICAYFDRNGLSVLDARVNTTRHGYALDNFIVTQTEHDVQYRDIANLVEQQLAARLAESAPLPEPSKGRLSRLSRTFPITPRVDLRADERGQYYILSVSANDRPGLLYSIARVLAEHRVGVHAARINTLGERVEDVFMLDGTGLSDNRLQIQVETELLRAIAV
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: SYP_MARMS
Sequence: MRASNYLFSTLRDAPTDAVVTSHQLMIRAGMIRQVSKGLYTWLPTGLKVFRKIENIVRDEMEKAGSLEVMMPGVQPAELWQETGRWQKYGPELLRLQDRHGREYCLGPTHEEVITELARNELTSYKQLPMNFFQIQTKFRDEVRPRFGVMRSREFCMKDAYSFHVGAESLQETYDIMHKAYCNVFDRIGLNYRPVRADTGSIGGAYSHEFHVLADSGEDDIAFSDSSDFAANIELAEAICLKEKADAPTQDITEVFTPDCKTIAKVAEFLKLDVTSTVKTMLIKAVDENDQPTIAALVLRGDHNINEIKVEKLAGVVIPFEFADEADIIAKTGCAPGSIGPKGLAEKGIRVIADRSAAVMSDFCAGANKDDYHFTGLNWERDCAEFEVADIRNVVEGDPSPDGQGTIVIKRGIEVGHIFQLGQQYAEALKATVLDENGKAQVMHMGCYGIGVSRIVAAAIEQNFDEKGILWPESIAPFDIAIVAMNYDKSEAVRTECDRLYAELKAKGLDVLLDDRKERPGVKFADCELLGIPHRLVVGDKGLEKGTLEYKYRKAGDNEDIAIADAVEFILSKK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OB84A_DROME
Sequence: MYSALVRACAVIAFLILSPNCARALQDHAKDNGDIFIINYDSFDGDVDDISTTTSAPREADYVDFDEVNRNCNASFITSMTNVLQFNNTGDLPDDKDKVTSMCYFHCFFEKSGLMTDYKLNTDLVRKYVWPATGDSVEACEAEGKDETNACMRGYAIVKCVFTRALTDARNKPTV
What are the official names of this protein?
General odorant-binding protein 84a, Odorant-binding protein 84a, Pheromone-binding protein-related protein 4, PBPRP-4.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in the lumen of olfactory hairs.
Protein: GSTZ1_DIACA
Sequence: MSSSETQKMQLYSFSLSSCAWRVRIALHLKGLDFEYKAVDLFKGEHLTPEFLKLNPLGYVPVLVHGDIVIADSLAIIMYLEEKFPENPLLPQDLQKRALNYQAANIVTSNIQPLQNLAVLNYIEEKLGSDEKLSWAKHHIKKGFSALEKLLKGHAGKYATGDEVGLADLFLAPQIIASITGFGMDMAEFPLLKSLNDAYLKYQHFRMRCQRISPMLDEAKS
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 1, GST class-zeta, SR8.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Zeta family.
Protein: RSMH_DEHMB
Sequence: MIEYPHIPVMLEESIQGLGVIPGGRYVDCTLGAGGHSEAILEHSYPGGQLLSIDADPSAITLAAERLKSFGSSVLLVNDNFANLKDICQRYEYMPVHGILFDLGLSSMQLDRQESGFSFQTEAPLDMRFSPEQELTAADIINGYDVTELSDLIWKYGEEPFSRRIARAIAEKRPFKTTTELAAAIERAVGGRHGRIHPATRTFQALRIAVNEELSHLESALSQAHSLLGHGGRLVVISYHSLEDRIVKQYFQKEAKGCICPDDIPQCVCDHQPSLRIINRRVITPSDEEISRNPRSRSAKMRVAERIIEPGEGRFFSSREDELVNHVSRTGSVQHGQAKHKGVVQRGGS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4E1_CAEEL
Sequence: MTETEQTTAPIYPLKRNWTWWYLNDERNKSWEDRLKKVYTFNTVSEFWALYDAIRPPSGLNALCDYNVFRDDIQPMWEVPENSNGGRWLIVIDKGKTPEMVDAIWLEILMALVGEQFGKDMESICGLVCNVRGKGSKISVWTKDCNDDETNMRIGVVLKEKLMAASKDHSKPLFDVIRYEDHESCQKKTSSVVKAKLSLHSSDAPVAEKSAV
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.  All 5 eIF4E proteins bind monomethyl cap structures.  Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing.  Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps.  Required for progression through meiotic divisions during spermatogenesis and for the production of viable sperm.  It is not required during oogenesis.
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-1, eIF-4E-1, eIF4E-1, eIF-4F 25 kDa subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
What are the subcellular locations of this protein?
Cytoplasm. Note=When associated with pgl-1.
Protein: RNHL_BACSU
Sequence: MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQEAEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAFPLFFIKWIPGKQNQKADLLAKEAIRLNEKN
What is the function of this protein?
Not known; does not have RNase H activity.
What are the official names of this protein?
14.7 kDa ribonuclease H-like protein.
What is the protein family that this protein belongs to?
Belongs to the RNase H family. EbsB subfamily.
Protein: GATA_CLOB1
Sequence: MDLTKLTAHELKDMLSNKEVKAEEITKAFLDRINLVDNKLGAYLYVSEEEAIKKAKEIDGKIEKNEELKALSGIPVGIKDNINVKGMQNTCASKILEGYTSPYDAHVTEKIKQEEGIILGKLNMDEFAMGSSTENSAFKLAKNPWDLERVPGGSSGGSAVAVAGSEATLSLGTDTGGSVRQPASFCGVVGLKPTYGRISRSGVVAFGSTLDQVGPMGKDVEDCALLTSVIAGLDKKDFTTVDKEVPDYKKSLTKDIKGKRIGIPKEFFGDGLDKNVRKSVEEAIKVLEANGAEVKPCSLPLMDYALSAYYIISSAEASSNLARFDGIRYGYRSKNFKDAKDIYLKSRSEGFGDEVKRRIMLGTYVLSAGYYDAYYKKALKVRKLIKDDFQRVFKEFDAIVSPTSPTTAFKVGEKKDDVMSMYLSDIYTVPISVAGVPAISLPCGMIDGLPVGLQIISDYFKEDVLFNLAYNYEQSVDFHKMRADF
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: LUXS_NEIG1
Sequence: MPLLDSFKVDHTRMHAPAVRVAKTMTTPKGDTITVFDLRFCIPNKEILPEKGIHTLEHLFAGFMRDHLNGAGVEIIDISPMGCRTGFYMSLIGTPSEQQVADAWLASMQDVLNVKDQSKIPELNEYQCGTYLMHSLAEAQQIAQNVLARKVAVNRNGDLALDESLLNA
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: NO25_MEDSA
Sequence: MVYSNTYMLLGLGVFVLLSSHVLAYNMRADPSIHDSTLDDQKSNDFVKTASIAECPPGPDTYLELSDSTLDDQKSMDYVKDASTVDHNCPPGPHTYLELSAWLQEEQNSIDKVKKVLRTDEAPDNQKGLEYKDARHNDGPIEISTRTEKDNFIPSDGPIEISTRTENENFIPSDEPIEISTGTEKENFISSDEPSEISSGAEKENFIPSVSQVDWRTFHAKYPWIKKDGPNTVTGSRKLLNDIAIK
What is the function of this protein?
Involved in the development and function of nodules.  It might participate in the biological process of symbiotic nitrogen fixation.
What are the official names of this protein?
Nodulin-25, N-25.
What are the subcellular locations of this protein?
Symbiosome, peribacteroid space.
Protein: ACTA_BOVIN
Sequence: MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, aortic smooth muscle, Alpha-actin-2.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: UBIC_VIBPA
Sequence: MNQPTSLYLASLLEVEWQKPEEFEFPNEFAKHWLEEQGSLSRRLKQHCQELTVELLQNHIVTAKTLKSDESQLLSEQDCLLREVVLCGDDCPWVVGRTLIPRTTLVDQQYDLAQQGDIPLGLTVFSADNVERDSLQMGWVHLPQGRFLARRSRLWMNHKPMLVAELFLSNSPIYAKERV
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDMD_PSEPU
Sequence: MNKLDVNQWFPIATTEDLPKRHVFHATLLGQEMAIWRDDSGSVNAWENRCPHRGLRLTLGANTGNELRCQYHGWTYESGTGGCTFVPAHRDAPPPNAARVNTFPVREKHGFIWTTLGQPPGEPISILDDAQLVNAVKTNLHSVVIDADIDGVVSVLRQNLSAFIDVFGAASAEDLHLKSMLQDRGILVTRSGSIAIHFYMQRSTISKCVVHAQVLTPGRPGYELQKNYSYAMNVIRRAAEAVATDLISITDISDQTIEKLEVVRENMTKAPPTHYICEVVTRTQETGDINSYWLKPIGYPLPAFSPGMHISITTPEGSIRQYSLVNGPDERESFIIGVKKEIQSRGGSRSMHEDVKVGTQLKVTLPRNGFPLVQTRKHPILVAGGIGITPILCMAQALDQQGSSYEIHYFARAFEHVPFQDRLTALGDRLNVHLGLGPDETRAKLPDIMEIHNAQDVDVYTCGPQPMIETVSAVALAHGIAEESIRFEFFSKKNDVPVSDEEYEVELKKTGQIFTVSPGSTLLQACLDNDVRIEASCEQGVCGTCITPVVSGDLEHHDTYLSKKERESGKWIMPCVSRCKSKKIVLDL
What is the function of this protein?
Involved in the caffeine degradation, which is the essential first step for assimilating the carbon and nitrogen in caffeine.  Catalyzes the oxidation of NADH and transfers electrons to NdmA and NdmB, which catalyze the N-demethylation reactions.
What are the official names of this protein?
Oxidoreductase NdmD.