PharMolix/UniProtQA huggingface dataset:
Protein: SP5D_BACSU
Sequence: MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSLAKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNMSEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLSHVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDMKLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVDPSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWKRGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGILFPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTVKKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKYLENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVKPRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGTKVKEGSKIRVYLTEEDEKEAAD
What is the function of this protein?
Penicillin-binding protein with an unknown catalytic activity.  May have a specialized role in the morphogenesis of spore cortex, which is a modified form of peptidoglycan.  Spore cortex formation is determined primarily by the mother cell.
What are the official names of this protein?
Stage V sporulation protein D, Sporulation-specific penicillin-binding protein.
What is the protein family that this protein belongs to?
Belongs to the transpeptidase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SPRT_ECOLI
Sequence: MKTSRLPIAIQQAVMRRLREKLAQANLKLGRNYPEPKLSYTQRGTSAGTAWLESYEIRLNPVLLLENSEAFIEEVVPHELAHLLVWKHFGRVAPHGKEWKWMMENVLGVPARRTHQFELQSVRRNTFPYRCKCQEHQLTVRRHNRVVRGEAVYRCVHCGEQLVAK
What is the function of this protein?
Involved in bolA gene expression at the stationary phase.
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPH_CLOB6
Sequence: MSYNLTDPYEIARYIKEAKKSTPIKAYIEGDLSNCDFTNIEKFNSGDLYILFGESEEILVIIEKNKDKIKNCRIEQDRRKSAIPLLDMLKINARIEPGATIRDKVIIGENAVIMMGAVINIGAEIGEGTMVDMNAVVGARGKLGKNVHLGAGAVVAGVLEPPSSDPCTIEDNVLIGANAVILEGIKIGKGSVVAAGSIVTTDVPENVVVAGAPAKIIKEVDVKTKDKTKLLDDLRK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: OBG_ACTPJ
Sequence: MKFIDEALIRVEAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLIADENLNTLIDYRFEKRYAAGRGENGRSAGCTGHRGNDITLRVPVGTRAIDNDTQEVIGDLTKHGMKMLVAKGGYHGLGNTRFKSSVNRAPRQKTNGTPGEKRDLLLELMLLADVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVARVGADRSFVVADIPGLIEGAADGAGLGIRFLKHLERCRVLIHLVDIMPIDESDPAQNISVIESELYQYSEKLSEKPTWLVFNKIDTIGEEEAQARAQEIAEQIGWEGDYYLISAATGQNVQNLTRDIMDFIEANPREVAEENTEADEVKFKWDDYHQQAMQNPIEEDWDDFDDDWSEEDEEGVEFVYTRS
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_LEPBL
Sequence: MPENKIRSTTILCVRKSGKVAIGGDGQVSMGNTVMKNTAKKIRRLYDGKILSGFAGSAADAFTLFELFEKKVQEFGGSLSRSAVELAREWRTDRMLRKLEALLIVADKEESFLISGTGDVISPDEGVIAIGSGGSYALAAAKALYDHTDLSAREIVESSMKIAANICIYTNDHITLEEIL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_SALPC
Sequence: MNIDLNADVGEGCASDSELLTLVSSANIACGFHAGDAQTMLTCVREALKNGVAFGAHPSFPDRDNFGRTAMVLPPETVYAQTLYQIGALGAIVQAQGGVMRHVKPHGMLYNQAAKDPHLAQAIAKAVHDYDPSLILVGLAGSELIRAGERHRLVTRQEVFADRGYQADGSLVPRMQPGALIHDEEQALAQTLDMVQAGRVKSVTGVWTTVTAQTVCIHGDGEYALAFARRLRAAFNARNIHVIA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: ARTN_HUMAN
Sequence: MELGLGGLSTLSHCPWPRQQPALWPTLAALALLSSVAEASLGSAPRSPAPREGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG
What is the function of this protein?
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex.  Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain.  Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
What are the official names of this protein?
Artemin, Enovin, Neublastin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family. GDNF subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PTJC_BACSU
Sequence: MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSFFLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVDALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVSTEIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNIVSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIAFQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFNINEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFSGYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEAAL
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.  This system is involved in lichenan transport.
What are the official names of this protein?
Lichenan permease IIC component, EIIC-Lic, PTS system lichenan-specific EIIC component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YLYB_BACSU
Sequence: MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVVNGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHPAPGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQLVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERFQDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHPRTGEYVEFEAPLPEDMAELIENLRKNG
What are the official names of this protein?
Uncharacterized RNA pseudouridine synthase YlyB, RNA pseudouridylate synthase, RNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: ILVC_ALKCK
Sequence: MAKVYYNGDVNEQVLEGKTVAIVGYGSQGHAHAQNLRESGVDVIIGLRPGKSWDKATEDGFSVYSVREASAKADIIMILSPDEHQPAIYKESIEPELTAGKALVFAHGFNIHFNQIVPPEHVDVFLAAPKGPGHLVRRTYTEGAGVPALIAVYQDATGQAKDIALAYAKQIGAARAGVLETTFKEETETDLFGEQAVLCGGTSALVKAGFETLVEAGYQPEIAYFECLHELKLIVDLMYEGGLEYMRYSISDTAQWGDFQAGPRIVTDETKAAMKEILSDIQKGKFAKGWILENKLNRPEYNAINEAEKNHPLEVVGRELREMMPFVKASKSKGVVANAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: Y618_TREPA
Sequence: MWRKCLGKVVLLGCALPCVAARISVSPKLGAYGDARGGPDLWGLCIKATDAEEVSGDPDDTEMEYLPPRYAPETPLVGLDVAFRAENGFLLQLTVDAALTRLMFRGQCLAGYSFRPGGG
What are the official names of this protein?
Uncharacterized protein TP_0618.
What is the protein family that this protein belongs to?
To T.pallidum TP_0127, TP_0315 and TP_0619.
Protein: Y538_BACAN
Sequence: MSIKYSNKINKIRTFALSLVFIGLFIAYLGVFFRENIIIMTTFMMVGFLAVIASTVVYFWIGMLSTKTVQIICPSCDKPTKMLGRVDACMHCNQPLTMDRDLEGKEFDEKYNKKSYKS
What are the official names of this protein?
UPF0295 protein BA_0538/GBAA_0538/BAS0506.
What is the protein family that this protein belongs to?
Belongs to the UPF0295 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TATC_MAIZE
Sequence: MGSAGALLWHTPQQLHGRGILFRQSRPLLRQRNLPLISLAAPALEPERRRRQCLRCAAVDGDGALRESGPLPQKESPSSGIGAALEDPPPGPPVENGSFGGPSQEEQSALYTFLYPSKDLLPDDKEMSIFDHLEELRDRIFISVLAVGAAILGCFAFSKDLVIFLEAPVTAQGVRFLQLSPGEFFFTTLKVSGYCGLLLGSPIILYEIIAFVIPGLTRDERKFLGPIVLGSSVLFYLGIFFSYTVLSPAALNFFVNYADGAVESLWSIDQYFEFILVLMFSTGLSFQVPVIQLLLGQLGLVSSDQMLSIWRYVVVGAVVAAAVLTPSTDPLTQMLLAGPLLGLYLGGAWMVKITGR
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane.  Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation.  TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation (By similarity).
What are the official names of this protein?
Sec-independent protein translocase protein TATC, chloroplastic, Protein TWIN-ARGININE TRANSLOCATION C.
What is the protein family that this protein belongs to?
Belongs to the TatC family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=The N- terminus is located in the stroma.
Protein: DNAI4_MOUSE
Sequence: MHSSPTSTRKQASFAASASAQPRKSISFINPSKSSAGKGYAASNPNKLAVSRTMGFLTDMKPAEKLNVPSAKTVQVLDSKGVDVTPRPLYHPDPHAASAKPNKLLTSQEGSLGSDYISSYSLYQNTLNPSMLGQYTRSVLGSSSVSKSSISTTESMSEDLEDSSYKRDRLASFTDVRVLRSTAEAAISKEELEKTIEIILTETETLRFFDLPTVMFSTESEEAEKIIEKNKKYETLCRNRLGNDLYVERMMQTFNGAPKNKEVQCEKIILEEKGVVATTWDLYDSYNIPETLLAAKRSGYSSKGSLPAKDRDPKIQDSESSSLMDIENVILAKVQEDEEDNSEAILKSDKLHQDLFYMERVLMENVFQPKLAAYRQLPVYKEHEPEEPEETLQVENLKVAEDEPKKEDEEEVEMELELEIATEQSTIPANLERLWSFSCDLTKGLNVSSLSWNKANPDLLAVGYGNFGFREQKKGMACCWSIKNPMWPERIYQSSYGVTSVDFSNSSPNLLAVGYHNGTVAIYNVQSSHNIPVLDSSESPQKHLGPVWQVQWIEQDRGTTGDDKREILVSISADGRISKWIIRKGLDCHDLMRLKRTTATGGKKGGEKEKKGEALISRQAPGMCFAFHPKDTNIYLAGTEEGLIHKCSCSYNEQYLETYRGHKGPVYKVTWNPFCPDVFLSCSADWGVMIWHQDTVKPFLSFYPTTYVVYDVSWSPKSAYIFAAANENRVEIWDLQISTLDPLIVNVANPGIKFTTVLFAKETDCLLVGDSDGQVAVYELRNMPTASDTSRGDVINILLGPKTNHTG
What is the function of this protein?
Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility.
What are the official names of this protein?
Dynein axonemal intermediate chain 4, WD repeat-containing protein 78.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Dynein axonemal particle.
Protein: RS19_CARHZ
Sequence: MGRSLKKGPYCDPKLLKKIEELNAKGEKRVIKTWSRRSTIFPQMVGHTIAVYDGRKHVPVYITEEMVGHKLGEFAPTRTFRGHGDHTERSTALK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: RNPA_COXBR
Sequence: MEKGFSVGWRIRTTAEFRRIYAARQRIIGRYYLLYYRENEIKHSRLGVVASKRNVRKAVWRNRVRRVVKEAFRIRKKDLPAFDIVVVAKASSVEADNKELYECINKLFTQLEKQSKRSSSV
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: MP05_DICCI
Sequence: MRKSQKLAFRKGQFRITDITGVSLRGEIIKQIIKPTIHAVFDVAVEEMDHDVDDIEILFITREEEEERRREDPDLYRLDAWDREVLKKTSMDEHNYKSPINCIYEYDYDVLQPVANFEEFFEIDFDHVPLWKVDIYGDFAFYGSDPYIKETKEYPEEYISDEKRSEVELDYLLYNSTKLEQHRQYIIKNKEHFTDVKPQILETGERAEHLLMKRFYYNKIDNVIERKQEIEEDPIYTYIKFDFGAKLDLRIARLYYLNFTRMERMDLENQQKLYEFEKAALKGIAFDNFMILFGVFLIWATHPYLYKKIPWRIRYFFEFHRDEVIEYILMIPQIPKITWEEIKAYWTGQVMFTVIPTFQYAWSFLGKKIDLETIQAWKILAKTLNDIY
What are the official names of this protein?
Uncharacterized mitochondrial protein Mp05, ORF388.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PEPX_STRS7
Sequence: MRYNQLSYIPTSLETAVAELQALGFAVQQEQAPKESFAIFLRKLFFHFQDTDYPLSHMIATKELDLLSFLASDEALTKEVFDLVALQVLGFIPAVDFTDTQDFIQKIGFPIVFDSQQLLLNLHQLLATRQKSGVTLIDSLVSQGLLPMDNCYHYFNGKALATFDTTSLIREVVYVEAPLDTDQDGQLDLIKVNIIRPKASTAIPSMMTASPYHQGINETANDKKLHRMEGELSPKAPRRITVEPTDFQPLATKPSRLPVNECQETFSHISSYTLNDYFLARGFANLYVSGVGTAGSTGFMTSGDYAQIESFKAVIDWLNGRATAYTSHKRDYQIKADWSNGLVATTGKSYLGTMSTGLATTGVDGLAVIIAEAAISSWYDYYRENGLVCSPGGYPGEDLDVLTELTYSRNLLPGDYLRHNDHYQELLSQQSQALDRQSGDYNQFWHDRNYLPQADRIKCEVVYTHGLQDWNVKPRQVYNIFNALPDSLGKHLFLHHGEHVYMHNWQSIDFREAMNALLCQKMLGQNNGFTLPTIIWQDNQKEQTWKELTAFGGHSKRQIALGEDHVLIDNHYGEEDFKRYGKDFRAFKAELFEGKANQAVIDILLEEDLPINGQACLKLKLKSSENKGILSAQLLDYGKKKRFGDLPAILELDSIDNGQQFAREALKELPFKDSPYRVVTKGVLNLQHRSGLLTIEDIPNDQWISITFHLQPTIYHMAKGDTLRVVLYTTDFEHTIRDNSNYALTLDLEQSYLLIPTDEEE
What is the function of this protein?
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Xaa-Pro dipeptidyl-peptidase, X-Pro dipeptidyl-peptidase, X-prolyl-dipeptidyl aminopeptidase, X-PDAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y880_PASMU
Sequence: MTRKIVDLARSCGILYLMLFIGEWIAHHLNIGIPASIWGLLLLFLGLTFRIIKLDWVLCSASLLIRYMALLFVPVSVGVIKYADVLFSQMNVLLLPNIVSTFLTLIVVGLLSDYLFSLSSFSHLRKKVARKQAEKA
What are the official names of this protein?
UPF0299 membrane protein PM0880.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FADB_YERPB
Sequence: MLYQSETLQLHWLENGIAELVFDAPGSVNKLDTKTVANLGEALNVLEKQSELKGLLLRSAKTALIVGADITEFLSLFNAPPEKLHQWLVFANTIFNRLEDLPVPTISAINGYALGGGCECILATDFRIASPEARIGLPETKLGIMPGFGGSVRLPRLLGADSALEIIATGKDVTANDALKIGLVDAVVDPEKLVGSALTMLKQAIDGKLDWQAARRPKLEPLKLNPTEAAMCFTIAKGRVMQVAGKHYPAPLTAVKTIEAAAKFGRTEALNLETNSFVPLAGSNEARALVGIFLNDQYVKAQAKKLSKGVAAPKLAAVLGAGIMGGGIAYQSALKSVPVIMKDINENSLDLGMNEAAKLLNKQLERGKVDGLKMASILATIRPTLDYAGIERAQVIVEAVVENPKVKAAVLAEVEALIGEDTVLASNTSTIPIDQLAKSLKRPENFCGMHFFNPVHQMPLVEIIRGAKTSDKTLAAVVAYATQMGKTPIVVNDCPGFFVNRVLFPYLAGFGMLVRDGGDFHQIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPERMNKDYRDAVDVMFDNQRFGQKNGQGFYRYTQDAKGKPRKENDEQVDKLLAEISQPLQEFSDEDIIARTMIPMINEVVRCLEEGIIASAAEGDMALVYGLGFPPFHGGVFRYLDTLGSANYVEMAQRYAHLGALYHVPAGLRAKAEHNESYYPVAAALLDVSTNQPA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: WLS_DROMO
Sequence: MSGTILENLSGRKLSILVSSLLLCQVACFLIGGLYAPVPAGHQIVMGIKCRDVAGRQNDTSFFLYSRGNGACDSVQDIDIEQDPLKMANQLVYVFQMPLPRDNRTLDYSRWQQNLIGVLQMDIAYDSSSELREPPKELQLTIDTRLAYRNKNDEDADWKPYAHSIEKRFLDCRAAHVGLQEILYTCDIIPLFELGALHHSFYLLNLRFPMDTPKRLNLQFGHMHDIILTAIHQNGGFTQVWLLLKSVLFPFIIGIMVWFWRRVHILQRSPALLEYMLLYLGGALSFLNLPLEYLTLSFEMPYMLLLSDVRQGIFYAMLLSFWLVFAGEHMLIQDSPNKSTIRSRYWKHLSAVVVGCISLFVFDICERGMQLRNPFYSIWTTPLGAKVAMSFIVLAGVSAGIYFLFLCYMVWKVFKDIGDKRTSLPSMSQARRLHYEGLIYRFKFLMLATLLCAGLTVAGFIMGQMAEGHWKWNEDIEIQLTSAFLTGVYGMWNIYIFALLILYAPSHKQWPTMRHSDETTQSNENIVASAASEEIEFSNLPSDSNPSEISSLTSFTRKVAFD
What is the function of this protein?
A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells.  In non-neuronal cells wls directs wg secretion.  The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26).  In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles.  Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip (By similarity).
What are the official names of this protein?
Protein wntless.
What is the protein family that this protein belongs to?
Belongs to the wntless family.
What are the subcellular locations of this protein?
Presynaptic cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=In non-neuronal cells, wls binds to wg in the Golgi and accompanies it to the plasma membrane where the two proteins dissociate. Wg is secreted and wls is then internalized and returns to the Golgi apparatus in a retromer-dependent manner. Wls and wg colocalize in the Golgi apparatus in wg-producing cells, and reduced expression is seen in non-producing cells. Endoplasmic reticulum expression is unchanged in wg-producing versus non-producing cells. In neuronal cells, wls is localized both pre- and postsynaptically and is transferred trans-synaptically from the pre- to the postsynaptic compartment (By similarity).
Protein: MSRA1_RHIME
Sequence: MFLIDMFNKKTILPDAATALPGREEEIPTATTHFVSGRPLQGPYPEGMKKVLFGMGCFWGAERLLWEIPGVYVTAAGYSGGLTPNPTYQETTTGLTGHTEVVLVVYDPAKVSLQRLLKTFFEEHDPTQGMRQGNDVGTTYRSAIYVYDEEQLAEANAARNAFQKALRVYNHDREITTEIAKAGPFYFAEDYHQQYLAKNPDGYCGLRGTGVSCPIGA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA 1, Protein-methionine-S-oxide reductase 1, Peptide-methionine (S)-S-oxide reductase 1, Peptide Met(O) reductase 1.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: REV_HV1LW
Sequence: MAGRSGDSDEDLLKAVRLIKFLYQSSSDPPPNPGGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAKPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTVLESGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: ERBB3_PONAB
Sequence: MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGKSCPPCHEVCKGRCWGSGPEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFQTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELKKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESTVSGSNEQCPRPVSLYPMPRGCLASESSEGHVTHSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPNAGTTPDEDYEYMNRQRGGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT
What is the function of this protein?
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins.  Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.  May also be activated by CSPG5.  Involved in the regulation of myeloid cell differentiation.
What are the official names of this protein?
Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.