PharMolix/UniProtQA huggingface dataset:
Protein: RLUA_HAEDU
Sequence: MALIEYHPPLNPFLEEVYRDNHIVVINKPSGLLSVPGNRPEYYDSVMTRVQQRYGFAEPAHRLDMATSGIILLALSKVAEKELKRQFRDREPKKHYIALLWGKLGDRVGQTGEINFPLICDWENRPRQKICYERGKKATTHYEVLEHLANNTTRVKFTPITGRSHQLRVHSLALGHPIIGDKFYANPLAKSLAPRLCLHAESLTIAHPISAELMTFNTEPTF
What is the function of this protein?
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
Dual-specificity RNA pseudouridine synthase RluA, 23S rRNA pseudouridine(746) synthase, Ribosomal large subunit pseudouridine synthase A, rRNA pseudouridylate synthase A, rRNA-uridine isomerase A, tRNA pseudouridine(32) synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: EST2A_RAT
Sequence: MPLARLPGWLYVVACGLLLLLQHVHGQDSASPIRNTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGLVLGSASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISDKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEILAINQVFKMIPGVVDGKFLPKHPQELLASGDFHPVPSIIGINTDECGWGIPVFLGLDHIIKKITRETLPTVLKSTAAQMMLPPECIDLIMEEYMGDTENPETLQEQFRHMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLPSFIKQVRPSHVKADHGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPNGEDLPHWPVLDHDEQYLQLNTQPAVGRALKARRLQFWTKTLPQKIQELKGSQSKHAEL
What is the function of this protein?
Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides.  Hydrolyzes permethrin faster than cypermethrin (By similarity).  Hydrolyzes retinyl esters (PubMed:12230550).
What are the official names of this protein?
Pyrethroid hydrolase Ces2a, Carboxylic ester hydrolase.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Microsome.
Protein: SAM50_RAT
Sequence: MGTVHARSLEPLPSSGTDFGALGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLERTKDDIIICEIGEVFKAKNLIEVMRRSHEAREKLLRLGIFRQVDVLIDTCHGEDALPNGLDVTFEVTELRRLTGSYNTMVGNNEGSMVLGLKLPNLLGRAEKVTFQFSYGTKETSYGLSFFKPQPGNFEKNFSVNLYKVTGQFPWSSLRETDRGVSAEYSFPLCKTSHTVKWEGVWRELGCLARTASFAVRKESGHSLKSSLSHAMVIDSRNSSILPRRGALLKVNQELAGYTGGDVSFIKEDFELQLNKPLVLDSVFSTSLWGGMLVPIGDKLSSIADRFYLGGPTSVRGFSMHSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGQGGFGELFRTHFFLNAGNLCNLNYGEGPRAHIRKLAECIRWSYGAGIVLRLGNIARLELNYCIPMGVQRGDRICDGVQFGAGIRFL
What is the function of this protein?
Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes.  Required for the assembly of TOMM40 into the TOM complex.
What are the official names of this protein?
Sorting and assembly machinery component 50 homolog.
What is the protein family that this protein belongs to?
Belongs to the SAM50/omp85 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm. Mitochondrion.
Protein: RL22_HAHCH
Sequence: MEVAAKLFGARLSAQKARLVADQVRGKRVEEALDILTFSPKKASSIIKKVLESAIANAEHNEGLDVDELKVATICVDEGPTMKRIKPRAKGRADRIFKRTCHITVKVAEE
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: HIS3_STRCO
Sequence: MTSSSPTGGGPGRPSALAPEIADRLKRSADGLLPAIAQQYDTGEVLMLGWMDDEALHRTLTTGRCTYWSRSRGEYWVKGDTSGHFQWVKSVALDCDADTVLVKVDQVGAACHTGTRTCFDTDVLLADQ
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4155_MYCUA
Sequence: MAGNSQRRGAIRKSGTKKGTSVGSGGQRRRGLEGRGPTPSAHMRPNHPAAKRAKAQQRRPARGRTDETETVLGRNPVLECLRAGVPSTALYVALGVEADERLTESVSRAADSGIPILEVPRTDLDRMTANHLHQGIALQVPPYNYAHPDDLLAAALDTPPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQRRSASVTAVAWRTSAGAAARMPVARATNLTRALKDWADRGVRVVGLDAGGDTAIDDLDGSDPIVVVVGSEGKGLSRLVRQTCDEVVSVPMAGPTESLNASVAAGVVLAEIARQRRT
What are the official names of this protein?
Uncharacterized tRNA/rRNA methyltransferase MUL_4155.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: 2ENR_CLOTY
Sequence: MKNKSLFEVIKIGKVEVXXKIXMAVMGAFG
What is the function of this protein?
Involved in fermentation of amino acids (Stickland reaction) such as leucine, isoleucine, valine and phenylalanine.
What are the official names of this protein?
2-enoate reductase.
Protein: SSRP_STRPI
Sequence: MAKGEGKVVAQNKKARHDYTIVDTLEAGMVLTGTEIKSVRAARINLKDGFAQVKNGEVWLSNVHIAPYEEGNIWNQEPERRRKLLLHKKQIQKLEQETKGTGMTLVPLKVYIKDGYAKLLLGLAKGKHDYDKRESIKRREQNRDIARVMKAVNQR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SYP_LISMC
Sequence: MRQTMTFIPTLKEVPADAEVKSHQLLLRAGFIRQTASGIYSYLPLATLMLRKIETIIREELEAIGAAELLMPALQPAELWQESGRWNDYGPELMRLKDRASRDFALGPTHEEVITALLRDEVKSYKRLPLTLYQIQTKFRDEKRPRFGLLRGREFIMKDAYSFHATSESLDEVYNLMHQAYSNIFTRCGLEFRSVIADSGSIGGNESKEFMALSDIGEDTIAYSDASDYAANTEMAPVLYMEKKSHELEKDMEKVATPDQKSIADIVEFLEVPIEKTMKSMLYQVDDEVIMVLVRGDHEVNDIKIKNALDATNVELVDPAVAVELLGANFGSLGPINVPENTRVFADNAVKDIVNAVVGANEDGFHYINVKPDRDFSVTSYFDLRMIQVGDLSPDGQGVIKFAEGIEVGHIFKLGTKYSEAMNATILDENGRAQPIIMGCYGIGVSRILSAIAEQSNDENGFVWDKQISPFDLHLIPVNMKSEEQVAFAETLYSSLQDAGFSVLIDDRAERAGVKFADADLIGLPIRITVGKKAAEGVVEVKIRKTGEMIEVRQDELLNTLPILFGDK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_METAR
Sequence: MEEESKSLPSKDNFSEWYNELLMTAQIMDVRYPIKGVYVWYPFGFSIRKKVYNMLRNLLDVDHQETYFPMLIPKPELLKESEHIKGFEDEVYWVTHGGLSELEVPLALRPTSETAIYPMYKLWIRSHADLPLKLYQIVNTFRYETKHTRPLIRLREITSFKEAHTAHATWDDAEKQVHEAMDLYSEFFTKLAVPFIVHKRPEWDKFPGADYTMAFDTMMPDGKSLQVGTVHHLGTKFAKTYDITYEDEKGERQYVNQTCYGISERCIAAVIGIHGDNKGLVLPPNASQTQVVIIPIIFKKDDGGVKEACQKVKELLRANDIVAVIDDADERPGAKYYKWEMKGTPFRIEIGPRDIKNNSVMLVRRDGKKESIPMDGLPETVRNKLFEFQTDLLNAARDSMLARVKACETLDEAKQQIENGWATMPWCGEKACGLEMENAVNCKLLGEAHTIKGAGKCPICGKATDRIITMARSY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_SACS2
Sequence: MILSDRDLKYYLEKSWIKIQPLREDTIRENGVDLRVGNEIARFKKTDKIFDPDNPDPSFFQTEKGEEFIIQPYEHVLLTTEEYIELNNDVMAFVNLRSTFARLGLFIPPTIVDAGFKGQVTIEVVGSSFPVKLKRSTRFIHLIFARTLTPVEYPYQGKYQGQKGVTLPKFNSQISSFYYQHQSI
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: KDUI_ECO27
Sequence: MDVRQSIHSAHAKTLDTQGLRNEFLVEKVFVADEYTMVYSHIDRIIVGGIMPVTKTVSVGGEVGKQLGVSYFLERRELGVINIGGAGTITVGGQCYEIGHRDALYVGKGAKEVVFASIDTATPAKFYYNCAPAHTTYPTKKVTPDEVSPVTLGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYFYFNMDDDACVFHMMGQPQETRHIVMHNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVKDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: FRE_SALTY
Sequence: MTTLSCKVTSVEAITDTVYRVRLVPDAAFSFRAGQYLMVVMDERDKRPFSMASTPDEKGFIELHIGASELNLYAMAVMDRILKDREIVVDIPHGDAWLRDDEERPLILIAGGTGFSYVRSILLTALARNPARDVTIYWGGREEKHLYDLSELEALSVNHPNLRIEPVVEQPEEGWRGRTGTVLTAVLQDYGTLAGHDIYIAGRFEMAKIARDLFCHERNAREDRLFGDAFAFI
What is the function of this protein?
Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides.
What are the official names of this protein?
NAD(P)H-flavin reductase, FMN reductase, Ferrisiderophore reductase C, NAD(P)H:flavin oxidoreductase, Riboflavin reductase [NAD(P)H].
What is the protein family that this protein belongs to?
Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family.
Protein: MSH2_HUMAN
Sequence: MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMSEENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair.  When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs.  MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.  MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long.  After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262).  ATP binding and hydrolysis play a pivotal role in mismatch repair functions.  The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone.  This transition is crucial for mismatch repair.  MutS alpha may also play a role in DNA homologous recombination repair.  In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
What are the official names of this protein?
DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: GP51_BPSP1
Sequence: MAKINKGYVANFIEENGFPEQGHFEEKKDLQAFYKHLSTEQLEEWVELEGLEVKDTDSDSIYRMRLCMAILYLNFPKKTAGKKKASPYKHISLEELVQMATDNDIEVKHTDSDKILRMRTIMALKEAGKLG
What are the official names of this protein?
Putative gene 51 protein.
Protein: RL322_LISMF
Sequence: MAVPFRRTSKAKKRKRRTHVKLQLPGMNECSNCGEYRLSHHVCPECGQYDGKDVANS
What are the official names of this protein?
50S ribosomal protein L32-2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RL27_BLOPB
Sequence: MAHKKAGGSTRNGRDSHSKRLGVKCFGGECVSSGTIIVRQRGNTFHPGKYVGCGRDYTLFALKSGKVLFEKRGALRRKFISIVS
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: LIGB_PHACH
Sequence: MAFKQLFAAISLALSLSAANAAAVIEKRATCSNGKTVGDASCCAWFDVLDDIQQNLFHGGQCGAEAHESIRLVFHDSIAISPAMEAQGKFGGGGADGSIMIFDDIETAFHPNIGLDEIVKLQKPFVQKHGVTPGAFIAFAGAVALSNCPGAPQMNFFTGRAPATQPAPDGLVPEPFHTVDQIINRVNDAGEFDELELVWMLSAHSVAAVNDVDPTVQGLPFDSTPGIFDSQFFVETQLRGTAFPGSGGNQGEVESPLPGEIRIQSDHTIARDSRTACEWQSFVNNQSKLVDDFQFIFLALTQLGQDPNAMTDCSDVIPQSKPIPGNLPFSFFPAGKTIKDVEQACAETPFPTLTTLPGPETSVQRIPPPPGA
What is the function of this protein?
Depolymerization of lignin.  Catalyzes the C(alpha)-C(beta) cleavage of the propyl side chains of lignin.
What are the official names of this protein?
Ligninase B, Diarylpropane peroxidase, Lignin peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ligninase subfamily.
Protein: AMY3_HORVU
Sequence: MANKHLSLSLFLVLLGLSASLASGQVLFQGFNWESWKHNGGWYNFLMGKVDDIAAAGITHVWLPPASQSVAEQGYMPGRLYDLDASKYGNKAQLKSLIGALHGKGVKAIADIVINHRTAEHKDGRGIYCIFEGVTPDARLDWGPHMICRDDRPYADGTGNPDTGADFGAAPDIDHLNLRVQKELAEWLNWLKADIGFDGWRFDFAKGYSADVAKIYIDRSEPSFAVAEIWTSLAYGGDGKPNLNQDQHRQELVNWVDKVGGKGPATTFDFTTKGILNVAVEGELWRLRGTDGKAPGMIGWWPAKAVTFVDNHDTGSTQHMWPFPSDRVMQGYAYILTHPGTPCIFYDHFFDWGLKEEIDRLVSVRTGA
What are the official names of this protein?
Alpha-amylase type B isozyme, 1,4-alpha-D-glucan glucanohydrolase, Clone PHV19.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: MTNX_BACCN
Sequence: MSIQIFCDFDGTITNSDNITSIMEHFAPPKAEEIKKQILAQELSIQEGVEQLFHLLPTNLHDDMIAFLKNNASIRSGFQEFVQFINKNDLSFYVILGGMDFFVHPLLDGLVPKEKIYCNETDFSKEYIEVKWPYPCDKHCNHHCGLCKSTLIRRLSSQQDFRIVIGDSITDLQAAKQADKVFARDFLITKCKEYHIPYTPFHTFYDIQNELQHLVEVKL
What is the function of this protein?
Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase, HK-MTPenyl-1-P phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MtnX family.
Protein: SUCC_POLNA
Sequence: MKIHEYQGKEILRNFGVPVPRGIPAFTVQEAVEAAQKLGGPVWVVKAQIHAGGRGKGGGVKVAKTIEDVKRIAGEILGMQLKTHQTGPEGQKVRRLYIEDGADIQKEYYVSLVTDRATQKVAFIASSEGGMDIEEVAHSTPEKIITEFIDPLTGLGEEQAVKIANGIGLPPESTAQAVDIFQKLYKCYMDTDASLVEINPLNRDSKNALMALDAKFNFDPNALFRHADIVAYRDLDEEDPAEVEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATAEKVTEAFKIMLKNPDVKGILVNIFGGIMKCDTIADGVIAACKAVNLSVPLVVRMKGTNEDLGKKMLAESGLPIIAADTMAEAATKIVAAVK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: FETP_POLAQ
Sequence: MARMVQCIKLNKEAEGMDFAPLPGELGKKIWNQVSKEAWAAWLKQQTMLINENRLNMADPRARQYLLKQVEKYFFEGGADMAQGYVPEAE
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: RNPH_RICRS
Sequence: MRQSGRKSNQLRPISLELSPLINAEGSCLIKIGNTHVMCSATCETTVPPFLRGQNQGWITAEYGMLPGSTSQRIKREAALGQQGGRTQEIQRLIGRAMRCVIDVRKLGERQIIIDCDVINADGGTRTAAITGSYVALHLAIRSLMKKRVLKVNPLISQIAAISCGIYKGEVILDLDYLEDSDADVDSNFVFAGNGNLIEVQGTAEKNPFSEEQFLAMLKLAKGGAAELFKLQNQVLLGS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: MUTS_LIMRJ
Sequence: MAKKTTPMMEQYQKVKDQYPDAFLFYRLGDFYELFNDDAVKGAQLLELTLTTRNHSAKNPIPMCGVPHRAVNNYIDILIDKGYKVAICEQMEDPKKAKGMVKRAVTRLITPGTQMDLNGEQARDNNYLAAISGQNGVFSIAYTDLSTGELKTTSLNNANDAVNELVNLQSKEVVVDGELPVEITTQFKQRNILQSHQPTVLKNAEISYLTQDLDDQAQQHVVALLVSYLLTTQKRSLAHMQKAIAYQPSSFMKIDHYSKTNLELMRNMRSGKRQGTLAWLLDETKTAMGSRLLKRWIDRPLINQNAISERQDKVQELLDHYFERSNLQQELIKVYDLERLAGRVAYGSVNGRDLIQLKTSLKQVPKIKYVLETLDSPVFEELQKQLDPLDDVADLIDQSIIEEPPIAVTEGGVIKDGYNDQLDQYRDAMNNGKQWIVDLQEHERKLTGINNLKIGYNHVFGYYIEVTKVNLDKLPKDRYERKQTLVNAERFSTPELKEKEALIMGAQEKSTALEYDIFVKIREQVKGQITRLQKLAQQLAELDVLQSFAVVSEDYHFVRPEMNTGHVLKIKDGRHPVVEKFMGHQEYVPNDVLMGEDTDILLITGPNMSGKSTYMRQLALIAVMAQIGCFVPAKSAELPIFDQVFTRIGAADDLISGESTFMVEMMEANNALTHATDRSLILFDEIGRGTATYDGMALAQAIIEYVHQHVRAKTLFSTHYHELTALENSLARLKNVHVGATEKDGELVFLHKVSAGPADKSYGIHVAKLAGMPSSLLKRADTILQKLEQKDVKLPNTPKPATDNYHTEPISAKINEAAPVKKEAAPVVEDNGQLELFATQPEKKESSVDRRILHQLKELNLMGMTPMDVMNQIYKWQQKLK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CU082_HUMAN
Sequence: MRQGCKFRGSSQKIRWSRSPPSSLLHTLRPRLLSAEITLQTNLPLQSPCCRLCFLRGTQAKTLK
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC00310.
Protein: CDII_YERPY
Sequence: MNDIVKSAWASVKMNTDFICVDTYSGYRSNQLDPLGVQHLSSPDVSDLDLGEMVKDALSHSRFVLPAPRTDIWIHPEVTFDLDLYDSRRTVERYDEWVKKLMVHYGYKTKRALFKDMKSCDICCNHDAITISPTRHEKLEVWGGTGLKGSDNVILSVDSSPTEIGAGLRLALSRCKG
What is the function of this protein?
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion.  Neutralizes the toxic activity of cognate toxin CdiA-YPIII (residues 954-1077).  Does not inhibit toxic activity of CdiA from other toxin-immunity modules.
What are the official names of this protein?
Immunity protein CdiI-YPIII, CdiI-YPIII.
Protein: ATPF_MOOTA
Sequence: MQAIFQALNFNPWTFLFQTLNLLVVMGLLYVFLYKPLGKVLADREARIEGNLNDAAAAREKAENILAEYRQQLQGARQEAQAILDRATKMAEETRAEIINRAREEAERTLAQARREIEGEKSKALAAIRSEAASLAILAAGKVLERSLTPDDQERLAREAIAEVERLQ
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ULAG_SALPB
Sequence: MSKVQSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPLMKTGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPQTCVDLWVGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDVRAVNYLFKTPGGNLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADILRMAESLNTKVVIPFHHDIWSNFQADPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL
What is the function of this protein?
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P.  Is essential for L-ascorbate utilization under anaerobic conditions.
What are the official names of this protein?
Probable L-ascorbate-6-phosphate lactonase UlaG, L-ascorbate utilization protein G.
What is the protein family that this protein belongs to?
Belongs to the UlaG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GTHB2_ICTPU
Sequence: MSVPASSFLLLCFLMNSFSPAQSYILPHCEPVNETVSVEKDGCPKCLVFQTAICSGHCLTKEPVYKSPFSNIYQHVCTYRDVRYETVRLPDCRPGVDPHVTYPVALSCECTLCTMDTSDCTIESLNPDFCMTQKEYILDY
What is the function of this protein?
Involved in gametogenesis and steroidogenesis.
What are the official names of this protein?
Gonadotropin subunit beta-2, GTH-II-beta, Gonadotropin beta-II chain, GtH beta-2.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: KAD_BRUSU
Sequence: MRLILLGPPGAGKGTQAGLLTKKHGIPQLSTGDMLRAAVAQQSEIGKRAKAVMDAGQLVSDEIVNQIVSERIDAPDCANGFILDGYPRTVPQAQALSQMLSGKGLKLDAVIELKVDENALVKRMESRVAETIAKGGQVRSDDNPEAFRKRLVEYREKTAPLSSYYAGTGELRVINGMAPVEEVTAEIERILVPA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.