PharMolix/UniProtQA huggingface dataset:
Protein: IF2A_RABIT
Sequence: PGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGRILLSELSR
What is the function of this protein?
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.  This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex.  Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.  EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming.
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-alpha family.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule. Note=Colocalizes with NANOS3 in the stress granules.
Protein: ISCS_SALPA
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFLTLDGTFGNPASRSHRFGWQAEEAVDIARNQIAELVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLNELEAAMRDDTILVSIMHVNNEIGVVQDIATIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRIRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMETEMARLRGLRNRLWNGIKDIEEVYLNGDLEQGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGMNDELAHSSIRFSLGRFTTEEEIDYTIDLVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_PHYMT
Sequence: MSRYTGSIWKVSRRLNYSLSETGKELIKRPYAPGMHGKKRIKAKDYGLQLQEKQKVRFTYGISEKQFKKIFKDAGKLKGIHGEMFLFLLESRLDNVVYRLGFAKTRQQARQLVNHGHILVDGKKVDIPSYSLRVGQIITLKEKSKDLIIVKEALANKLNRVDYISLNKELVGKYVRIPHRDELLPNIKEQLIVEFYNRK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: GRH1_CAEEL
Sequence: MSFQLDQSTSVIKTAPPGRLEFKNEPIDIASSNIQDLAKMQTLDGYYQQTSLQLPQSQQYHRMYENVYNNQQILYAQTQNFQYPSTLLTNGSLAQTEWRGQQMDTSAYSNTGYSRSSTSQQPQYTQQVTENERIVYKPVDMPSPVDSGIGGDISILNPKEEFFTSADGGSMLERSSERTLSHRDSPLVIPKLYNNLGFQYVLEAPISTSVRRDDDRMTYVNKGQFYTVSLEYTPDLNKCLKSQTVKSQLMVVFREDKTYEEEIKTWQSWHARQHVSKQRILEIDSKNSSGMIGQIEEIGNNAVQFYWNPSDPSGVRISIAVQCLSTDFSTQKGVKGLPLHVQIDTYDGENDKVPFHRGYCQIKVFCDKGAERKLRDEDKRAQKRKVQEYTAGALPGGRKKSDGEYHDQCERSEFYHMRELDKPAALFIAPEEFEPRYVDSTSLSFDMSEIEPIPTKRPRTSERIMLYVRKRDEQIYQPLHVVPASLSGLALAIANKFGADPDKMSGVYKRCAKGITVKVDDEMLRLYCNEDTFIIDVEHATDGSTAATLIEVAPTNPNSYSNS
What is the function of this protein?
Probable transcription factor (PubMed:12888489, PubMed:36688410).  Binds a motif with the core sequence 5'-C[ACT][TG]G-3' in regulatory elements of target genes (PubMed:12888489, PubMed:36688410).  Many putative target genes show oscillating expression levels, perhaps as a result of rhythmic variation in accumulation of grh-1 (PubMed:36688410).  Plays a role in proper cuticle formation and/or barrier function and is required repetitively during development, for successful completion of each molt (PubMed:36688410).  Involved in modulating lifespan (PubMed:35013237).  Plays a role in defense response to bacteria (PubMed:35013237).  May act upstream of the p38 MAP kinase / pmk-1 pathway (PubMed:35013237).  May act downstream of the insulin/IGF-1 receptor signaling (IIS) pathway (PubMed:35013237).
What are the official names of this protein?
Grainyhead-like protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the grh/CP2 family. Grainyhead subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAFA_STRSW
Sequence: MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDNVTELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLLCGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDITGRRKVRLASGREASALEVQREYYEKAVDFVERRGIRTGTVEQVLELWGRTLDAIEAEDLDRIGTEIDWVMKYKLIERYRAKHNMTMSHPRVAQIDLAYHDIHRRRGLYYLLERKGQATRICNDLKIFEGKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVEKLIAGM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: ERF10_ARATH
Sequence: MEGGGVADVAVPGTRKRDRPYKGIRMRKWGKWVAEIREPNKRSRLWLGSYSTPEAAARAYDTAVFYLRGPTARLNFPELLPGEKFSDEDMSAATIRKKATEVGAQVDALGTAVQNNRHRVFGQNRDSDVDNKNFHRNYQNGEREEEEEDEDDKRLRSGGRLLDRVDLNKLPDPESSDEEWESKH
What is the function of this protein?
Probably acts as a transcriptional activator.  Binds to the GCC-box pathogenesis-related promoter element.  May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
What are the official names of this protein?
Ethylene-responsive transcription factor ERF010.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: EF1B2_ARATH
Sequence: MAVTFSDLHTEEGVKSVEEHLAGKTYISGDQLSVDDVKVYAAVPVKPSDAFPNASKWYESVASQLAKSFPGKAVGVQFGGSAAAAPAVEAEAPAAAADDDDDMDLFGDETEEEKKAAEEREAAKKDTKKPKESGKSSVLMDVKPWDDETDMKKLEEAVRGVEMPGLFWGASKLVPVGYGIKKLTIMFTIVDDLVSPDNLIEDFLTSEPNNEYIQSCDIVAFNKI
What is the function of this protein?
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
What are the official names of this protein?
Elongation factor 1-beta 2, EF-1-beta 2, Elongation factor 1-beta' 2, EF-1-beta' 2, Elongation factor 1B-alpha 2, eEF-1B alpha 2.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: MACB_ALCBS
Sequence: MPLIELCNIRKRYPAGDQDVEVLHGIDLSIEAGEFLAIMGSSGSGKSTLMHILGCLDQPSDGEYRFSGQPVTAMDHDQLAWLRREMFGFVFQSYHLIGTASAWENVALPAIYAGVPREERKQRAQQLLTDLGLEDRLENRPSQLSGGQQQRVSIARALMNGGKVILADEPTGALDSASGEAVMDQLRSLAEQGHTVIVITHDAKVAAHADRVVEIHDGNLISDTRHHDHLHERAKPVSAPPKESVMPDPGEVMEAVVMALRSLRANWMRTLLTLLGIVIGVGAVVVMLAIGEGAKQDVVAQINERGTNLLVVRPDRGMQRVADGVIATLVPADAQALESLPNISIAVPEISGNVTARANGMDISTSVQAVSEDFPSLRDWQPVQGIFFGEEDLKSYSPVAVIGQTVKENLFPEGDPLGQFLLLDSIPFQVIGVMSAQGASDRGEDQDDVVIVPLSTGTLRLFGQNYLNSITVAVDDVTQIDATEAAAVALLTQRHGKQDVRVFNMASLLEMVSETQNTLTALLGSIAAISLLVGGIGVMNIMLVSVTERIHEIGIRMATGARQRNILQQFLTESVVVSALGGIVGVVIGVLVGWLLMLFGMAIVFSVPVMVVSFVCAAGIGLLFGFAPALKAARLNPVEALSND
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS19_CORK4
Sequence: MPRSLKKGPFVDEHLLSKVDAQNDKGTKQVIKTWSRRSTILPDFIGHTFAVHDGRKHVPVFIDDSMVGHKLGEFAPTKTFKGHVKDDKKGRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: 6PGL_BUCAT
Sequence: MKQVVYIANSESKNIEVWNLCKSGKMNLIQKIETDGKIQPINIIQKRNLLYAGIFPDNKIITYSINHNGFLEKKNESNIPGKANYISFDKKKEFLFCSSYHSNFISVSPLNKFGIPQNPIQIIYNIEGCHAAKMNYKYNILFVISLKEDCIYLYYLTDFGILKSTEQNILHTQKKSGPRHIIFHPNQDFIYTINELNGTIDVWKIYKKNNVIKVKNIQNIHVLKNRFLKDYWCSDIHITSCGRFLYACDRFFNIISLFHINQNDNKLVFFKSYDTEEQPRSFNINSHNTHLIVAGEKSNTFIIYGISNSTGELKKINVYSTGQRPVWILIHALC
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: COAE_LEPIC
Sequence: MQNSDSGKKTFLIGITGMIGGGKSTATKILEEMGCFGINADRLAKRYTEPDSPILIELVELLGSEILDEQGKPDRKKISEIVFNNPKKLSRLNQLIHPLVRKDFQKILETTAKGKMVIWEVPLLFETDAYTLCDATVTVDSDPEESILRTISRDKVKKEDVLARIKNQLPLTEKLKRADYILRNRGNIDSLREECKSLYSTLLGKML
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCPP_SHEB9
Sequence: MQQKIIKIKVGSKNPVKINAATKAMAQLFPESIIDASGMDAPSGVAAQPMTDKDTRQGAINRVHYCQQQDQQDTQADYYFAMEGGVDCFDFGPATFAYIAIGHKDQLAIGRSAILPLPMQVYRALEAGEELGHVMDRLFNTVNIKQKGGAIGLLTHGHATRESNYTQAIILAMAPLLNPDIYAQTC
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: LOXA_PHAVU
Sequence: MFGILNRGHKIKGTVVLMTKNVFDFNEFVSTTRGGIVGAAGGLFGAATDIVGGIVDGATAIFSRNIAIQLISATKTDGLGNGKVGKQTFLEKHLPSLPNLGDRQDAFNVYFEWDENFGIPEAFYIKNFMQSEFFLVSLTLEDIPNHGTIHFVCNSWVYNAKSYKRDRIFFANKTYLPNETPASLVKYRKEELENLRGDGTGERKEYDRIYDYAVYNDLGNPDKNKNLARTTLGGSSDFPYPRRGRTGRKSTRKDPKCEIPTSDTYIPRDENFGHLKSGDFLTYAIKSLTQNVLPTFQKAFGFNNEFDTFEDVRGLFEGGLYLPTDVISKISPIPVLKEILRTDGEQVLKFPPPHVIRVTKSAWMTDEEFGREMLAGVNPCLIQRLQEFPPKSKLDVTVYGDQTSTMTKEHLEINLGGLTVEEALHGNRLFILDHHDAFIPYLERINDLPTAKCYATRTILFLKDDNTLKPLAIELSLPNPGGKGANSRVILPADGGAESTIWLLAKAYVVVNDSCYHQLMSHWLNTHAVMEPFVIATNRHLSVLHPIYKLLLPHYRDTMNINALARQSLINAGGVIERSFLPGEFAVEMSSAVYKSWVFTDQALPADLIKRGMAVEDPSSPYGLRLVVEDYPYAVDGLEIWDTIQTWVKDYVSLYYPTNDAVKKDTELQAWWKEAVEKGHGDLKDKPWWPKLNTPQDLIHTCSIIIWIASALHAAVNFGQYPYGGFILNRPTITRRLLPEPGTKEYGELTSNYQKAYLRTITGKVEAIVDLSVIEILSRHASDEVYLGQRDNPNWTNNIKALQAFKRFGQKLKEIEEKIMGRNKDSSLRNRNGPVKMPYTVLLPTCEDEGLTFRGIPNSISI
What is the function of this protein?
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.  It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.
What are the official names of this protein?
Linoleate 9S-lipoxygenase 1, Lipoxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_RICCN
Sequence: MLDNFIAHQATKEFSVSEISNKIKELLENNFGYIKVKGEISGLKIANSGHAYFNLKENTAILACTCWRPILAKITFPLNDGMEVVISGKLSSYAGNSRYQLSVDNLQPTGLGAMLQILNERKAKLEKEGLFNKIRIPIPFLPDKIGVITSITGAVIKDIIHRIRERFPTRIIIWPVSVQGENSGNEIAEAIEGFNNLEEVNKPRVIIVARGGGSIEDLWSFNDEILVRAAYNSKIPIISAVGHEVDYTLIDLAADKRAPTPTAAAEFAVPVRSILNNTLQSYEKILLNNTSRLIKYHEQNIVNYNKIHRYLSHYINNRQQLLDETGFNLLDALPCFIELQETKIKSFSKERVNPAKIINYKTLELTHQTAYLSKSANNTLKNFEYKLELNSTLLASLDYHNVLKRGFAIVKGETGNFLSSKMTAANEKIFNIKFSDGEIKVVRA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_STRPZ
Sequence: MTKRALISVSDKSGIIDFAKELKNLGWDIISTGGTKVALDNAGVETIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDADSHLQAAKDNNIELIDLVVVNLYPFKETILRPDVTYDLAVENIDIGGPSMLRSAAKNHASVTVVADPADYATVLGELADAGQTTFETRQRLAAKVFRHTAAYDALIAEYFTTQVGEAKPEKLTITYDLKQAMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDRPTVVVLKHMNPCGIGQADDIETAWDYAYEADPVSIFGGIVVLNREVDAATAKKMHPIFLEIIIAPSYSEEALAILTNKKKNLRILELPFDAQAASEVEAEYTGVVGGLLVQNQDVVAENPSDWQVVTDRQPTEQEATALEFAWKAIKYVKSNGIIITNDHMTLGLGAGQTNRVGSVKIAIEQAKDHLDGAVLASDAFFPFADNIEEIAAAGIKAIIQPGGSVRDQDSIDAANKHGLTMIFTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: MURE_LISIN
Sequence: MKLKELMQAIPVYTGEASAAIEVNQIAQDSRKVQPGTLFICIDGEIVDGHQFADRAVQLGAVAIIAEKQLDVSVPVLYVRDSKRAMAMLADYFYGSPTQALKLVGITGTNGKTTVSHLVEQIVRENGEQTGLIGTMYRKIGDEILETKNTTPDSLTLQETFRDMLLSGVSTAVMEVSSHALVQGRVYGSDYDVAVFMNLSQDHLDYHHTMEEYAYAKSLLFAQLGNSYNLSNPKIAVLNADDKESVRMQTATAAHIITFGIKEPADFSASNIQITSHGSTFDLKTPVGDFALKIKMIGNFSVYNVLAAIATSFALRIPVINAIATVESIPGVKGRFELVNAGQDFPVIVDYSHTPDSLLNVLQTIDEFAEKRVFVVVGCGGDRDKGKRPQMAKIAVDYATNPIFTSDNPRSEDPHAIIEDMIQGVPGSDSYVVHENRRDAIRYAVNMAEAGDVILIAGKGHEDYQVIGDEVIDFDDRVEARIAIEKKLGLA
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP26A_DANRE
Sequence: MGLYTLMVTFLCTIVLPVLLFLAAVKLWEMLMIRRVDPNCRSPLPPGTMGLPFIGETLQLILQRRKFLRMKRQKYGCIYKTHLFGNPTVRVMGADNVRQILLGEHKLVSVQWPASVRTILGSDTLSNVHGVQHKNKKKAIMRAFSRDALEHYIPVIQQEVKSAIQEWLQKDSCVLVYPEMKKLMFRIAMRILLGFEPEQIKTDEQELVEAFEEMIKNLFSLPIDVPFSGLYRGLRARNFIHSKIEENIRKKIQDDDNENEQKYKDALQLLIENSRRSDEPFSLQAMKEAATELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVQEKVEMGMYTPGKGLSMELLDQLKYTGCVIKETLRINPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADVFPNKEEFQPERFMSKGLEDGSRFNYIPFGGGSRMCVGKEFAKVLLKIFLVELTQHCNWILSNGPPTMKTGPTIYPVDNLPTKFTSYVRN
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription (PubMed:8939936).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).  Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 (PubMed:8939936).  Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers.  May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity).
What are the official names of this protein?
Cytochrome P450 26A1, Cytochrome P450RAI, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: MNHF2_STAA1
Sequence: MIQTITHIMIISSLIIFGIALIICLFRLIKGPTTADRVVTFDTTSAVVMSIVGVLSVLMGTVSFLDSIMLIAIISFVSSVSISRFIGGGHVFNGNNKRNL
What are the official names of this protein?
Putative antiporter subunit mnhF2, Mrp complex subunit F2, Putative NADH-ubiquinone oxidoreductase subunit mnhF2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLP6_ARATH
Sequence: MLTTMQRVHNKPIDSIGGFKHLVKQSNGGDGGVTATDMQEPSIETDKLSYEIFSILESKFLFGYDDDLKLMESRSRDPSPEQETASPAMVEALNGVVPGTVKNQRGKVCVLSIDSGGMRGIIPGKALAYLEHALKSKSGDPNARIADYFDVASGSGIGGIFTAMLFASSDGNRPIFKAEDTWRFLAMKGKSFYNKSPPGILNRVMKTGSGGSGGSGSKLEKAMKESFEELTLKDTLKPVLIPCYDLTSSAPFLFSRADALETDGYDFKLWEVCRATWAEPGVFEPVEMRSVDGKTRCVAVDGGLAMSNPTAAAITHVLHNKQEFPFVRGVEDLLVLSLGTGQLVDVKYDCDKVMKWKAKHWARPAVRISADGAADTVDQAVSMAFGQCRRSNYVRIQANGSSFGPCKPNIDTDASPSNVNMLVGVAEEMLKQKNAESVLFGGKKINEESNYEKLDWLAGELVLEHQRRSCRIAPTVAFKQSGDRRVDQQTIFKDIDCMF
What is the function of this protein?
Possesses non-specific lipolytic acyl hydrolase (LAH) activity.  Hydrolyzes phospholipids as well as galactolipids.  May play a role in disease resistance (By similarity).
What are the official names of this protein?
Patatin-like protein 6, AtPLP6, Patatin-related phospholipase A IIIalpha, pPLAIIIa, Phospholipase A IIB, AtPLAIIB.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
Protein: RL16_FRASN
Sequence: MLIPRKVAHRKQHHPKRTGAAKGGTRIAFGEYAIQSLESAYVTNRQIESARIAMTRHIRRGGKVWINIYPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRIMFELSGVAEPVAREAMRRAIHKLPMKCRFVTREGGA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RS13_DESAH
Sequence: MARIAGVDLPRNKHVEIALTYIYGIGRTRSQQILEKVGINPTLKSDALTEEQVNDIRKVIDSDFKVEGELRTQISMNIKRLMDLGCYRGLRHRKSLPCRGQRTSTNARTRKGPKRAAVKKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: YIDD_CLAM3
Sequence: MKRALTSVVLAPRNAAIAVISLYRRVVSPIYGDVCRYYPSCSAYGLEAVQEHGLVHGGVLAAWRVCRCHPWAEGGIDDVPARRVQQYRRTRLGFVVAPSHGKG
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: P24D5_ARATH
Sequence: MAINRIAHGSLFLTVVLFFLTVNYGEAIWLTIPTTGGTKCVSEEIQSNVVVLADYYVVDEHNPENTPAVSSKVTSPYGNNLHHQENVTHGQFAFTTQEAGNYLACFWIDSSHHLANPITLGVDWKMGIAAKDWDSVAKKEKIEGVELQLRRLEGLVLSIRENLNYIKDREAEMREVSETTNSRVAWFSIMSLGVCVVVVGSQILYLKRYFHKKKLI
What is the function of this protein?
Involved in vesicular protein trafficking.  Mainly functions in the early secretory pathway.  Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).  Interacts with p24beta2 at endoplasmic reticulum export sites for endoplasmic reticulum exit and coupled transport to the Golgi apparatus.  Once in the Golgi, interacts very efficiently with the COPI machinery for retrograde transport back to the endoplasmic reticulum.
What are the official names of this protein?
Transmembrane emp24 domain-containing protein p24delta5, Atp24, p24 family protein delta1c, p24delta1c, p24 family protein delta5, p24delta5.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Cycles between the endoplasmic reticulum and Golgi via COPI and COPII dependent pathways. Mainly located in endoplasmic reticulum.
Protein: KDPA_BACMK
Sequence: MIWVAVVITMLLFILVAKPTGIYLEKAFQGSKKLDKVFGPFEKLIFKITGVKGYNQTWKQYALSLVLLNGFMIVVVYFIFRLQGVLPLNPAHIEGMEPTLAFNTAISFMADTNLQHYSGENGLSYLSQLIGITFLMFAAPATTLAIVMAFIRGLAGKELGNFFVDFTRALTRVFLPIAFIAALVFVALGVPQTLDGAVTAQTIDGAKQSILRGPVASFVSIKELGNNGGGFFGANSTHPFENPGQMSNILQMMLMMLLPTALPFTYGRMVGNKKQGRILFVSLFMVFLLGFITITTSELHGNPVLNGMGIEHVQGSTEGKEVRFGTVFSSLYATVTTAAETGAVNTMHDTLTPIGGLVPLVNMMLNTVYGGVGAGFVNIIMYAIIAVFISGLMVGRTPEFLGKKIEGKEMKLIAVTILFHPLLILGFSALALSTSLGTDAISHSGFHGLTQVVYEYTSSAANNGSGFEGLGDNTPFWNITTGLVMFLGRYFSLITMLAVAASLKEKTVVPETVGTFRTDNGLFGGIFIGTIVIVGALTFFPMLVLGPIAEFLTLK
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.