PharMolix/UniProtQA huggingface dataset:
Protein: GLMU_YERPS
Sequence: MSNSSMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAQHVHLVYGHGGELLKKTLADPSLNWVLQAEQLGTGHAMQQAAPHFADDEDILMLYGDVPLISVDTLQRLLAAKPEGGIGLLTVKLDNPSGYGRIVRENGDVVGIVEHKDASDAQREINEINTGILVANGRDLKRWLSLLDNNNAQGEFYITDIIALAHADGKKIATVHPTRLSEVEGVNNRLQLSALERVFQTEQAEKLLLAGVMLLDPSRFDLRGELTHGRDITIDTNVIIEGHVILGDRVRIGTGCVLKNCVIGDDSEISPYTVLEDARLDANCTVGPFARLRPGAELAEGAHVGNFVEIKKARLGKGSKAGHLSYLGDAEIGAGVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVANGATIGAGTTVTRDVAENELVISRVKQVHIQGWKRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUV91_BOVIN
Sequence: MAESLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKPPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPAGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
What is the function of this protein?
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate.  H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones.  Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.  H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.  SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length.  Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes.  The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.  Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase SUV39H1, Suppressor of variegation 3-9 homolog 1, Su(var)3-9 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Protein: GLYA_THEKO
Sequence: MAEGYREYRDKVLGFIEDHENWRKHTINLIASENVTSPSVTRAVASGFMHKYAEGWPKQRYYQGCKYVDEVELIGVELFTKLFGSDFADLRPISGTNANQAVFFGLTQPGDKAIVLHTSHGGHISHMPFGAAGMRGLEVHTWPFDNEEFNIDVDKAEKLIREVEPKIVVFGGSLFPFPHPVKELAPVAKEVGAYVMYDGAHVLGLIAGKQFQDPLREGADIITASTHKTFPGPQGGVIIYKRFGETEEIAKLQWAIFPGVLSNHHLHHMAGKVITAAEMLEYGEKYAAQIVKNAKALAEALAEEGFKVIGEDKGYTESHQVIVDVSDLHPAAGGWAAPLLEEAGIILNKNLLPWDPLEKVNEPSGLRIGVQEMTRVGMMEDEMKEIARFIRRVLIDKEDPAKVRRDVYGFRAEYQKVYYSFDHGLPLRLRE
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAML1_MOUSE
Sequence: MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAAATAPVAAPAPASAPAAARLDAADGPEHGRPVAHLHDTVKRSLDSAASPQNGDQPNGYGDLFPGHKKTRREAPLGVSVSANGLPPASPLGQPDKPSGGDTLQTAGKHSLGLDPINKKCLADSGIHLNGGSNSSEPFPLSLSKELKQEPVDDLPCMIAGAGGSVAQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFTEDFEEKKDPEPPGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGASSAPVGTDSPSLGSSQTLFHTTSQPGVDNSSPNLMPASAQAQSAQRALTSVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQAAPAPGPGQLATWQQAGPSHSPLDVPYPMEKPASPSGYKQDFTNSKLLMMPGVNKSSPRPGGPYLQPSHSNLLSHQSPSNLNQNPVNNQGSVLDYGNTKPLSHYKADCGQGGPGSGQNKPALMAYLPQQLPHLSNEQNSLFLMKPKSGNMPFRSLVPPGQEQNPSSVPVAAPAASVGTQPTVSVASTHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQQQLQQQQFLQRQHLLAEQEKQQFQRHLTRPPPQYQDPTQSTFPQQVGQFTGPSAAVPGMNNLGPSNSSCPRVFPQPGTLMSMGPGHAPVSSLPSSSGQQDRGVAQFTGSQSLPQNSLYGMASGLAQIVAQPPPQATSTHAHIPRQTNVGQNASTSAAYGQNSLGSASLSQQHSKGTLPPGLTKPQVPRVSAAMGSQNASWQHQGMPNLSSQTSGNSSVNPFTAAPSFHIQQAHLKLAGQQFSQAMPSRPMAPLSSAGAAGPMLPPVSAQQRNSAPASAPPQAAPQQGLPGLSPSGPELGAFGQSPTSQMSGRPGLHCAQAYPVRTMGQELPFAYSGQPGSSGLSSVAGHTDLIDSLLKNRTSEEWINELDDLLGSQ
What is the function of this protein?
Acts as a transcriptional coactivator for NOTCH proteins.  Has been shown to amplify NOTCH-induced transcription of HES1.  Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8.  Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription.  Induces phosphorylation and localization of CREBBP to nuclear foci.  Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
What are the official names of this protein?
Mastermind-like protein 1, Mam-1.
What is the protein family that this protein belongs to?
Belongs to the mastermind family.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Nuclear, in a punctate manner.
Protein: LACC_STRPQ
Sequence: MILTVTLNPAIDVSYPLDELKCDTVNRVVDVTKTPGGKGLNVCRVLNEFGETVKATGCIGGESGDFIINHLPDSILSRFYKISGYTRTCIAILHEGNQTEILEKGPMLSVDEIDGFTHHFKYLLNDVDVVTLSGSLPAGMPDDYYQKLIGIANLNGKKTVLDCSGNALEAVLKGDSKPTVIKPNLEELSQLLGKEMTKDFKALKAVLQDELFEGIEWIIVSLGADGVFAKHKDTFYNVDIPKIKIVSAVGSGDSTVAGIASGLANDEDDRALLTKANVLGMLNAQEKTTGHVNMANYDKLYQSIKVKEV
What are the official names of this protein?
Tagatose-6-phosphate kinase, Phosphotagatokinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
Protein: S15A4_BOVIN
Sequence: MEGAGDERAPLLGARRTAFAGRRAACAAVLLTELLERAAFYGVTANLVLFLNGTAFGWEGAEASQALLLFMGLTYLVSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPATRSALCGAPGPTNVRNCSAPPCTDTPTRYCAPAVLSALALVGLGVGAVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAIVSLGGIAYIQQNVSFVTGYAIPAVCIGVAFVVFLCGQTFFITKPPDGSAFTDMFRILVYSCRPQKRIREHSPSGEGIGVFQQSSKHSLFDSCKMSRGGPFPEDKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLKIPEISSITTNPHTFPAAWLTMFDAVLILLLIPLKDKLVDPILKRNGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLDLVKEKTINQTIGNVVYYAADLPIWWQVPQYVLIGVSEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALVSLKAIGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIVSVKYDRQRSRANGTPASRRT
What is the function of this protein?
Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response.  Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (By similarity).  Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity).  Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand.  Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs).  Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity).  Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation.  Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity).
What are the official names of this protein?
Solute carrier family 15 member 4, Peptide/histidine transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: MTGA_SALAR
Sequence: MSKRRLAPLTFLRRLLFRTLVALVVFWGGGIALFSVVPVPFSAVMAERQISAWLSGEFGYVAHSDWVSMEDISPWMGLAVMAAEDQKFPEHWGFDVLAIEKALAHNERNESRIRGASTLSQQTVKNLFLWDGRSWVRKGLEAGLTLGIETVWSKKRILTVYLNIAEFGDGIFGVEAAARRYFNKPASRLNMTEAALLAAVLPNPLRYKADAPSGYVRSRQSWILRQMRQLGGESFMTRNQLY
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DUT_CHLT2
Sequence: MKFFCKLESGSSLPEYATSGASGADVRANINEPIAILPGQRALIPTGISVEIPHGYEIQVRSRSGLASKYGVIVLQSPGTVDADYRGEIRVILANLGEATFIVEPGMRIAQLVVAKVEQVSFVETQEELTATARGTGGFGHTGEC
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RMT2_ASPFU
Sequence: MADPLADFGSNVDLTVQEILLAASQHDVPKLRRLIRSNDKDGNPANVKDPETGFSPLHAAIAACEPDEAQTETNGVNGETSSASTEQKSLVQSAAETVKYLLQEGAIWNDLDLNDETPGCIARRLGLTELYEMIVDAGVRAELLLNRLDGYEPLSDDEDDQETGQGEDAANEPAAEEDQDGAPELVETTAADASAAEASTEGPGPDVTSSRYLDSNLTFTNDRLLDQDQNGVMMAWETEIMSRSAKKLLPTTGLRVMNIGHGMGIVDGFIQEQSPAAHHIVEAHPDVVAEMKRKGWHEKPGVVIHEGRWQDILPALVAQGETFDAIYYDTFAESYADFREFFSEQVIGLLEQDGKWGFFNGMGADRQISYDVYQKVVEMDLFEAGFDVEWEEIKVPKLEGEWTGVRRPYWVVDNYRLPLCKFMD
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins.  Monomethylates ribosomal protein L12.
What are the official names of this protein?
Protein arginine N-methyltransferase 2, Protein-arginine N5-methyltransferase, Type IV protein arginine N-methyltransferase, Type IV PRMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LIMD1_XENLA
Sequence: MDTYDELSLEASKFIQDLTLYEASKDGLFRVDKGLSNNPEFEETKRIFAAKMAKIHLQNQQKSIPDTGISEGNGLTHQYNYSLPKSVEEGPVIYNGLSNSSVGPSDYKTYRESYKGKPDIDSADRSEESVFKHDSEIMLPSPLGKVGNTIPTQQFTSKKAISPSIESLERERTIKNNITGFENYRLCNSSSMKNCKPHQNSRHGEVEDTMAENFTENKTPFKQCSALISSSVTFGDDTHTNIPQKKLFNLPSTSSINTQNNSDDVYLSKTNAAKEFHGEQRGLCSTNSLGFGNPNDVISASYCVGYNDNFPGEIKQKQSPHYTFHSGHSSVDEQPQAIPFCCKDSSGQGPASTIDSDHTDILQDSSALMKIKLPCQTLSQSSKQGSSKAEKKLEAITRHVEQEMDAHNKADYFGTCVKCSKGVYGASQACQAMGNLYHNGCFICSACSRKLRGKAFYFVNGKVYCEEDFLYSGFHQSADRCFVCGHWIMDMILQALGKSFHPGCFRCVVCNECLDGVPFTVDMENKIYCVKDYHKILAPKCAVCSLPILPSEGTDETIRVVSMDKDYHIDCYRCECCALELNNEDDHRCYPLDGHLFCHNCHLKYLENHNLS
What is the function of this protein?
Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development.
What are the official names of this protein?
LIM domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the zyxin/ajuba family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LPXD_DELAS
Sequence: MSVLLGQILDALGGELVGGDREMPISRIAPLDSAGAGDLSFLSNPRYRQQLAASEAACVIVAPAMRELAQQRGACIVVPDPYAYFARATQWWKRNCRSVAPAGIHPSAVVHESAIVDASATIGPLCVVEEGATIGAHTVLKSRVTIGENCHVGARCLLHSGVVLGADGFGFAPENGAWVKIEQLGGVRIGDDVEIGANTCIDRGALDDTVIEDGVKLDNLIQIGHNVHVGKHTAMAGCVGVAGSARIGAHCTVGGGAIVLGHLQLADRVHISAATVVTRSLTQSGVYTGMFPVDENAKWEKNAATLKQLHSMRDRIKALERQLQQSADQGHNGTQ
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: RL32_MESM1
Sequence: MAIVPKRKTSKQRKRLRRSHHALDIQNLVKCSNCSQKIQQHRTCMFCGFYKNKKVEGFQARNDR
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: YIDC_PSET1
Sequence: MESQRTFLFIGLMLVSFLLFQEWNTDYNTPKADPSATTQTLNPTSSESEDYVPTSSDSALPASATLAKRSVIEITTDVFKVKIDTRGGDIVETYLLQYEETKGSETPYMLLGEFDGKQYFSQSGLIGLNGPDASAQGRPTYHVEQKSYTLTGDELRVPLQFTDSNGVNFTKTYVFKKGQYDVALEYTINNTTSTPLQVQLYTQVKRTVQDKGSMVDQNYLGAAYGTDDDPYEKYSFSDMADKNLNKITLGGYVAFIQHYFVSAWVPMQDQSNTLYSLITKSNAAIIGVKDEAVNIQAGSEQTLTATYYMGPKESDVLEAIHPDLDLTVDYGWLWFISQPLFVLLKWLHSILGNWGVAIIAITIIVKSLMYPLTKAQYTSMAKMRALQPKMAALKEKFGDDRQKFGQATMEMYKKEKVNPMGGCFPILLQMPIFLALFYVFLESTELRHAEFIFWLTDLSAKDPYYVLPILFGASMFITQKLQPMTVTDPMQQKMMTFMPVIFSVFFLWFPSGLVLYWLVSNLISIVQMLIIYRGMEKKGIKVRG
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSPH2_SALT1
Sequence: MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAYAGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPATTAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIRFDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLAEDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVDEIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALREKQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway.  Contributes to virulence in calves.
What are the official names of this protein?
E3 ubiquitin-protein ligase SspH2, RING-type E3 ubiquitin transferase SspH2, Salmonella secreted protein H2, Secreted effector protein sspH2.
What is the protein family that this protein belongs to?
Belongs to the LRR-containing bacterial E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. Localizes at the periphery of the host cell, specifically in areas of actin polymerization. Localizes to the apical membrane of polarized epithelial cells.
Protein: POTA_ECOUT
Sequence: MGQSKKLNKQPNSLSPLVQLAGIRKCFDGKEVIPQLDLTINNGEFLTLLGPSGCGKTTVLRLIAGLETVDSGRIMLDNEDITHVPAENRYVNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEITPRVMEALRMVQLETFAQRKPHQLSGGQQQRVAIARAVVNKPRLLLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVAGFIGEINMFNATVIERLDEQRVRANVEGRECNIYVNFAVEPGQKLHVLLRPEDLRVEEINDDNHAEGLIGYVRERNYKGMTLESVVELENGKMVMVSEFFNEDDPDFDHSLDQKMAINWVESWEVVLADEEHK
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y2547_BRUO2
Sequence: MTETPLLSVRGLAKHYQTRSATLKILDNVSFDIARGEVVGLVGESGSGKTTIGRSVLRLIEPTAGQIMFDGADVATLSAREMRRQRRRMQYIFQDPFASLSPRMTIGEILMEGLNIQGIGTKAERLERARKALEQVELPPDTINRYAHEFSGGQRQRIGIARALTLEPDFIVADEPVSALDVSIQAQVVNLLRDLQQRLGLTMLFISHDLAVVEYICDRVIVLYLGRIMEIASSEDLYARPQHPYTRALLSAIPSPDPDARTERQILRGDIPSPANPPSGCVFRTRCPMAIDACATTVPQLREVRPGHFKACIRDNI
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative peptide import ATP-binding protein BOV_A0347.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y7I4_ENCCU
Sequence: MRYLELGCISKTNKLFQKLQDLNPLLNIEIEAYSCKSSRRQRGRFVEKPLGYLLSALELRFPDYDFCGESWGSFRRKTLAEVLNEMTYSISTTHKNSDDVKEFVGFLEVILHRSVSLGGCEIFSYENRMGPFEDCLWYFSFLFFNKKQRRVVMLNAFMSRS
What are the official names of this protein?
Uncharacterized protein ECU07_1840.
Protein: MANA_DICDI
Sequence: MVIKKLFILIFCLFLIINEINGKKTKINDIKKSKPKLSSTLLNVHIVAHTHDDVGWLKTVDEYYYGSNMSIAFAGVQYTLDTAITCLLANPERKFIYVEIAFFQRWWDEQSTTMQNIVKGLVESGQLEFINGGYCMNDEATTYYDDTIDQMTLGHQFLWENFGVMPKIGWHIDPFGHSATQARIFGQLGFDAFIIGRMDYQDIEARLENKQMEFMWRSTQSTPENQVFTSVLRAMYCTPDGFNFEQGDDPIQDDPNLFDNNVDSRAEQFTQVALEYATHYRTNNVLIPFGCDFAYLNAQMYYKNIDKLIAHINSNPDKYGLNLLYSTPSIYIDAVNDANLVWEVKTDDLFPYADNEFSYWTGYFVSRPALKGYVRQNNALLHVVEQMLVTSSNLMPSSRSEQLVDDIVIMREVMGIAQHHDAVSGTEQQHVADDYAERLSIGNCASLETINTVVGTLLTANGNSKSAAATPTISFCPLLNQSICPATDPLSSGTSVPVLIYNSLSWTRNEPVRIPIPIANVTVTSSSNGSITSQVNQINGTFILEFLATIPPLGYSTYIITSTASDFVEPNSIPAIIIQDEIIVSGGGKINEKVSYNDPIILENDYINVQFSSQDGSILSITNKTSGVTSSITQEYIWYNPSVGNDDSAQCSGAYIFRPVEDFAYPYNNATPSVSIIRGEISSSIRRFWSNEMVQTFRLYSNADHLEVEEIIGPIDISDGIGKEIVSRYTTTLVTDQTWYSDSQGMEMQKRITNYRPSWNLTVVQPTSGNYVPVNAIAYIQDPNQSLQFTIVTDRSRGCASLRDGQLDMMMHRRTLKDDGRGVGQPMNESTQIVTTSKLIFHDISSYAQSHYRPAALSLSHPLLPMFTTTQQSSNDWNSQYQGVYSPLTSASPLPNGLKIQTLQWLDNQDNTILLRIENIYQIDGQDSQDPQTITLDLSTIFSTITITSATEMNLTGVQKLSNLSRLKWKTVDGKNYDHKSSSSTKEDSSNGFVFTFSPMQIRTFIITTN
What are the official names of this protein?
Lysosomal alpha-mannosidase, Laman, Alpha-D-mannoside mannohydrolase, Alpha-mannosidase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 38 family.
What are the subcellular locations of this protein?
[Alpha-mannosidase 60 kDa subunit]: Lysosome. Note=A few precursors are secreted. The mature 58 and 60 kDa subunits are lysosomal. SUBCELLULAR LOCATION: [Alpha-mannosidase 58 kDa subunit]: Lysosome.
Protein: BRX1_PONAB
Sequence: MAATKRKRRGGFAVQAKKPKRNEKDAEPPAKRHATAEEVEEEERDRIPGPVCKGKWKNKERILIFSSRGINFRTRHLMQDLRMLMPHSKADTKMDRKDKLFVINEVCEMKNCNKCIYFEAKKKQDLYMWLSNSPHGPSAKFLVQNIHTLAELKMTGNCLKGSRPLLSFDPAFDELPHYALLKELLIQILSTPRYHPKSQPFVDHVFTFTILDNRIWFRNFQIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSPNMHRRVTRSITAAKYREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKKRIYKRQRKMKQRMDSGKTK
What is the function of this protein?
Required for biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein BRX1 homolog, Brix domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the BRX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NANA_STAA1
Sequence: MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQVGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEKIVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSNDIIETVLSMGIYPTLKEILRHRDIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.