PharMolix/UniProtQA huggingface dataset:
Protein: ENTS_ECOLI
Sequence: MNKQSWLLNLSLLKTHPAFRAVFLARFISIVSLGLLGVAVPVQIQMMTHSTWQVGLSVTLTGGAMFVGLMVGGVLADRYERKKVILLARGTCGIGFIGLCLNALLPEPSLLAIYLLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMIGGLLLATGGVAWNYGLAAAGTFITLLPLLSLPALPPPPQPREHPLKSLLAGFRFLLASPLVGGIALLGGLLTMASAVRVLYPALADNWQMSAAQIGFLYAAIPLGAAIGALTSGKLAHSARPGLLMLLSTLGSFLAIGLFGLMPMWILGVVCLALFGWLSAVSSLLQYTMLQTQTPEAMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLVELRHFRQTPPQVTASDS
What is the function of this protein?
Component of an export pathway for enterobactin (PubMed:12068807).  Overexpression reduces intracellular arabinose concentrations (PubMed:22952739).
What are the official names of this protein?
Enterobactin exporter EntS, Protein p43.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KSR1_MOUSE
Sequence: MDRAALRAAAMGEKKEGGGGGAAADGGAGAAVSRALQQCGQLQKLIDISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVKYICKQQQSKLSVTPSDRTAELNSYPRFSDWLYIFNVRPEVVQEIPQELTLDALLEMDEAKAKEMLRRWGASTEECSRLQQALTCLRKVTGLGGEHKMDSGWSSTDARDSSLGPPMDMLSSLGRAGASTQGPRSISVSALPASDSPVPGLSEGLSDSCIPLHTSGRLTPRALHSFITPPTTPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVTPMKFELPHGSPQLVRRDIGLSVTHRFSTKSWLSQVCNVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRITFLPLARLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSPGQRDSRFSFPDISACSQAAPLSSTADSTRLDDQPKTDVLGVHEAEAEEPEAGKSEAEDDEEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREERRENQLKLSHDWLCYLAPEIVREMIPGRDEDQLPFSKAADVYAFGTVWYELQARDWPFKHQPAEALIWQIGSGEGVRRVLASVSLGKEVGEILSACWAFDLQERPSFSLLMDMLERLPKLNRRLSHPGHFWKSADINSSKVMPRFERFGLGTLESGNPKM
What is the function of this protein?
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (PubMed:10409742, PubMed:12932319, PubMed:21102438, PubMed:21441104).  Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (By similarity).  Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (PubMed:21102438).  Its kinase activity is unsure (PubMed:21441104).  Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (PubMed:21441104).
What are the official names of this protein?
Kinase suppressor of Ras 1, mKSR1, Protein Hb.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cell projection, ruffle membrane. Endoplasmic reticulum membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
Protein: RPOY_STAAS
Sequence: MAVFKVFYQHNRDEVIVRENTQSLYVEAQTEEQVRRYLKDRNFNIEFITKLEGAHLDYEKENSEHFNVEIAK
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: YIDD_CLOB1
Sequence: MKNLLICIIKMYRKYISPLKRPSCRFYPTCSQYSIEAIEKYGALKGTLISIKRILKCHPFNEGGYDPVK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYTE_SACS2
Sequence: MIILFIHASDFSFNVKERAIKEPEEAKLKSIELKNTLVCFTTVEKGDDEEILSKAIDDILDVYSKVKADSVVIYPYAHLSSNLANPDTAIKILESLENLLKDKVKVYRAPFGWYKAFSISCYGHPLSELSRRIRKTEELEKSEELKYCEKFGFPSSSESAFMRRATIGYLRNLFQPLFESENNENVRDGEMSILYQNVESGRILPCINENPRIVVVYGGVRELNFPKEINDSKNRIRVWWVNESKIYVDVGRLIYYFILESVKQQPPTLPDWLNPIQVRLLPVKKDFLDFSIQVAERLRKEGIRVNIDDLDDSLGNKIRRAGTDWIPFVIVIGEREVKTNTLTVKIRARNEQKSMTVEELVKEIKDEVKERQNLPLYYTLYRHKNN
What is the function of this protein?
Freestanding tRNA editing subunit of threonine--tRNA ligase, the catalytic subunit is AC Q97VW8.  Deacylates (edits) mischarged L-seryl-tRNA(Thr) in trans, removing L-serine, has no aminoacylation activity.  In vitro when both subunits are present, or if the 2 subunits are fused, L-seryl-tRNA(Thr) is no longer produced.  Has no activity on correctly acylated L-seryl-tRNA(Ser) or L-threonyl-tRNA(Thr) (PubMed:15240874).  Editing is probably catalyzed by the 2'-OH of A76 of tRNA(Thr) (By similarity).
What are the official names of this protein?
Threonine--tRNA ligase editing subunit, Ser-tRNA(Thr) hydrolase, Threonyl-tRNA synthetase editing subunit, ThrS-ed.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Archaea-specific ThrRS editing domain subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHS_HERA2
Sequence: MPVLAKAALQQALEQRSGWTVVDGQISKTYGLATFPFAIEFVRRIADAAEEVNHHPDIDIRYNKVTIALSTHDEKGITEKDFGLADTIDRIFAAAQ
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: ZDH24_HUMAN
Sequence: MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPALSALLRAHTPLHMAALLLLPWLMLLTGRVSLAQFALAFVTDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHSYDLGPCHNLQAALGPRWALVWLWPFLASPLPGDGITFQTTADVGHTAS
What is the function of this protein?
Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
What are the official names of this protein?
Probable palmitoyltransferase ZDHHC24, Zinc finger DHHC domain-containing protein 24.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BGL05_ARATH
Sequence: MEQFFALFTIFLSFAFPGRCSDVFSRSDFPEGFLFGAGTSAYQWEGAAAEDGRKPSVWDTLCYSRNIGNGDVTCDGYHKYKEDVKLMVDTNLDAFRFSISWSRLIPNGRGSVNQKGLQFYKNLISELITHGIEPHVTLYHYDHPQYLEDEYGGWVNNMMIKDFTAYVDVCFREFGNYVKFWTTINEANVFTIGGYNDGDTPPGRCSLPGKNCLLGNSSTETYIVGHNLLLAHASASRLYKQKYKDKQGGSIGFGLYLMGLTPSTSSKDDAIATQRAKDFYFGWFLGPLIFGDYPDTMKRTIGSRLPVFSEEESEQVKGSSDFIGINHYFAASVTNIKFKPSISGNPDFYSDMGAYVTYLGNFSVIEYPVAPWTMEAVLEYIKQSYDNPPVYILENGTPMTQHKDTHRVEYMNAYIGGVLKSIRNGSDTRGYFVWSFMDLFELIGRYDYGYGLYSVNFSDPHRKRSPRLSAHWYSDFLKGKTSFLDSKGIKELQSNFSSSS
What are the official names of this protein?
Putative beta-glucosidase 5, AtBGLU5.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: SERA_ARCFU
Sequence: MKVLVAEPISEEAIDYMRKNGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQAAKNLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAEQIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALYEAIKAGKVAAAALDVYEKEPPSPDNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVNMAKGLPVRNAVNLPSIEPSDFEFMMPFLTLAEKMGKIASVRLGGAIRKVKVTCSGKLATKNTEFVTRALLKGLFEPILSNEINLVSAKPVAVERGITIEESKVESVEHYESLLEVWVESNGKEMYLAGTCFGNEYRILKIDVYNVNFVPKGHYIISLHEDKPGVIGRVGTLFGRNNINIAGMIVGRSGDKPGGIQLMLLLVDDPPTPEVLEEMTKLDGIIDATYVEL
What are the official names of this protein?
D-3-phosphoglycerate dehydrogenase, PGDH.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: RECF_PSEU2
Sequence: MSLSRVSVTGVRNLHPVTLSPSPRINILYGANGSGKTSVLEAIHLLGIARSFRSSRLLPVIQYEQPSCTVFGQVDLAQGGHSNLGVSRDRQGEFQIRIDGQNARSAAQLAEILPLQLINPDSFRLLEGAPKIRRQFLDWGVFHVEPRFMATWQRLQKALKQRNSWLRHGTLDAASQAAWDRELCSASDEIDEFRRAYIKALKPVFEQTLSELVELEGLTLSYYRGWDKEKELSTVLASSIHRDQQMGHTQAGPQRADLRLRLGAHNAADILSRGQQKLVVCALRIAQGHLVSQVRRGQCIYLVDDLPSELDDNHRRALCRLLEELRCQVFITCVDQEFLREGWQTETPVALFHVEQGRITQTHDHRE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM41_DANRE
Sequence: MGVLSALARGFVRGADRMAEWTSKRGPRTFYKSRGARPTGIVTSSRKFIPIRAMIPEFAVPNLEGFNLKAYVSYKTPAGTEEPMTPEKLFNEVVAPQIQRDIEEGVFSEDNLEKYGLEKTQEGKLFKLHPKNFAR
What is the function of this protein?
Component of the mitochondrial ribosome large subunit.  Also involved in apoptosis and cell cycle (By similarity).
What are the official names of this protein?
39S ribosomal protein L41, mitochondrial, L41mt, MRP-L41.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HUTI_PYRAR
Sequence: MVIIRAKQLVTALNMPWRYRDEVAVINDAAVVIRDGVIIDVGTWEEIKRRHPHANIWDFGDNLITPGLVDPHTHLLFAGSREDELERKLQGESYEEITRKGGGIYKTVKYTKETSDQELLNILQKRIQLATSFGTTTVEVKTGYGLDIDQELRLARILKSVKSPIDVVTTFLVHIPPPAGRENYVKEVLKAIPHAGTTYVDVFCDSIAFNVEETRTILKKAAEAGYKLRLHADELEYIGCSDLVEELPIDSADHLLNTPPENVRKIAKSGTVATLLPVTILTLRTSKKPPIDEMRRLRVPIAIGTDFSPNSWCLNMQTAIELAVYLLGLTPLEALIAATANAAYSLRLTDRGIIQPGKIADLVIWDVPNYHWLAYEIGRNKAKLVLKKGEPLRFL
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM61_NOSS1
Sequence: MKQLQDEITQALTKLDGGSEFHEDSWERPEGGGGRSRVLRDGAIFEQAGVNFSEVWGSHLPPSILAQRPEAEGHGFYATGTSLVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHQTLKLACDEHHPEYYPVFKRWCDEYFYLKHRDETRGVGGLFFDYQDGQGVLYRGPNPKGEAANYSNQVGEPASRDWEDLFSFIQGSGKAFLPAYVPIVERRHGMEYGDRQRNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYGYQPEPNSPEAELYDTFLKPQDWSNWTANQ
What is the function of this protein?
Key enzyme in heme biosynthesis.  Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity).
What are the official names of this protein?
Coproporphyrinogen-III oxidase, aerobic 1, Coprogen oxidase 1, Coproporphyrinogenase 1.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIP1_MOUSE
Sequence: MDRMASSMKQVSNPLPKVLSRRGVGAGMEAAERESFERTQTVSVNKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAMLCWKFCHVFHKLLRDGHPNVLKDSLRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTRMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTTAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFQRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEVSSPDSEPVLEKDDLMDMDASQQTLFDNKFDDVFGSSLSSDPFNFNNQNGVNKDEKDHLIERLYREISGLTGQLDNMKIESQRAMLQLKGRVSELEAELAEQQHLGRQAMDDCEFLRTELDELKRQREDTEKAQRSLTEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSVARQAQVDLEREKKELADSFARTQEQQDVLENLKHELATSRQELQVLHSNLETSAQSEAKWLTQIAELEKEQGSLATVAAQREEELSALRDQLESTQIKLAGAQESMCQQVKDQRKTLLAGIRKAAEREIQEALSQLEEPTLISCAGSTDHLLSKVSSVSSCLEQLEKNGSQYLACPEDISELLHSITLLAHLTGDTIIQGSATSLRAPPEPADSLTEACRQYGRETLAYLSSLEEEGTMENADVTALRNCLSRVKTLGEELLPRGLDIKQEELGDLVDKEMAATSAAIEAATTRIEEILSKSRAGDTGVKLEVNERILGSCTSLMQAIKVLVVASKDLQKEIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATIMVDAADLVVQGKGKFEELMVCSREIAASTAQLVAASKVKANKGSLNLTQLQQASRGVNQATAAVVASTISGKSQIEETDSMDFSSMTLTQIKRQEMDSQVRVLELENDLQKERQKLGELRKKHYELAGVAEGWEEGTEASPSTVQEAIPDKE
What is the function of this protein?
Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11577110).  Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (PubMed:12839988, PubMed:17329427).  Regulates presynaptic nerve terminal activity (PubMed:17928447).  Enhances androgen receptor (AR)-mediated transcription (By similarity).  May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (By similarity).  Binds 3-phosphoinositides (via ENTH domain) (By similarity).  May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (By similarity).  May play a functional role in the cell filament networks (By similarity).  May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11604514, PubMed:14998932, PubMed:16967501, PubMed:17928447).
What are the official names of this protein?
Huntingtin-interacting protein 1, HIP-1, Huntingtin-interacting protein I, HIP-I.
What is the protein family that this protein belongs to?
Belongs to the SLA2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR (By similarity).
Protein: PYRE_ERWT9
Sequence: MKAWQRQFIEFAINKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAQALVDSGIDFDLVFGPAYKGIPIATTTVVALADHYDRDVPYCFNRKEAKDHGEGGTLVGSPLQGKIMLVDDVITAGTAIRESMEIIAAHRAKLAGVLISLDRQERGSGAISAIQEVERDYGCKVISIITLNELVAYLAEKPEMADSLIAVRAYRDEFGI
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: UHRF1_XENTR
Sequence: MWIQVRTMDGRDTRRIDSLSKLTKVEDLRARIQQIFGVALESQRLFYRGKQMENGHTLFDYSVGLNDIVQLLVRQIPDSVPTKDKECGISDADSGCGSGQGESDKNSSCGEGATDVDGQPAGINSENVGPSLYKKNDLVDARDLNMGAWFEAQIVSVSKRVNPDGMSAEILDTSAASDDIIYHVKYEDYPENGVVQLTYKDVRLRARTTLPWHDLKVGQVVMVNYNPDEPKERGYWYDAEILRKRETRTIKEIYVKVLLGDAGDSLNDCRIRFVDEIYKIEEPGSAYITTESPQKRQNGPECKHCKDNPKRACRMCACYVCGGKQDPEKQLLCDECDMAFHIYCLKPPLSAIPQDEDWYCPDCRNDASEVVLAGEKLKESKKKAKMASASSSSQRDWGKGMACVGRSRECTIVPSNHYGPIPGVPVGTLWKFRVQVSESGVHRPHVAGIHGRSNDGSYSLVLAGGYEDDVDNGSEFTYTGSGGRDLSGNKRTAEQSCDQKLTNMNRALALNCSAPINDKEGAVAKDWRAGKPVRVVRNTKGKKHSKYAPEDGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDEEPAPWSKEGKERIKKLGLVMQYPDGYLESLASKEREKENKTEDELSESPSKGKRKRNSAGSGLSDAKSTPKKTKVESYKLSLDQKTLIKQDDLNAKLWREVMSFLKEGPKFLSKVEETFLCICCQEVVYEPITTECHHNICKGCLDRSFKALVHNCPACRHDLGKNYSLNVNKPLQAILSQLFPGYERGR
What is the function of this protein?
Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification.  Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication.  In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins.  Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication.  Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications.  Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins.  However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo.
What are the official names of this protein?
E3 ubiquitin-protein ligase UHRF1, RING-type E3 ubiquitin transferase UHRF1, Ubiquitin-like PHD and RING finger domain-containing protein 1, Ubiquitin-like-containing PHD and RING finger domains protein 1.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions (By similarity).
Protein: VIP1_RAT
Sequence: MWSLTANEDEDESATAHFFLGAGDEGLGTCGIGMRTGESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPPCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLTMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASSEGQDLQREPPAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETKDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPAKPSDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPAGLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDNPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNTQMIEEKQGLGLLQETPGDGTPEFHIELAESTQSPQEPPVEISPPGSQDDTEVNQTCQEVPDTIQPCHDILEEIGQPNQEVPDISQLLLKNHDTATNTCQPCQASQLSKKVYEEICQLCQDNPEESNQLCQEVSVELGRMVHRFPVSIGSTTQETLMEIGRPTQEIPEEPCQEFSEKVGMLTQKASAISELSQDILETDNPSQELSEETDLQAQEVSEEIDQEPEVVDELSNEDIS
What is the function of this protein?
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4.  PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation.  Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4.  Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.  Activated when cells are exposed to hyperosmotic stress.
What are the official names of this protein?
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1, Diphosphoinositol pentakisphosphate kinase 1, Histidine acid phosphatase domain-containing protein 2A, InsP6 and PP-IP5 kinase 1, VIP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.
Protein: KNS1_YEAST
Sequence: MSQNIQIGTRKRSRANMNNSTTTGPANNTSSNKTFLDNFEETRTNKLLDEMFARQNSFLTDNLRNSLDLNQADNPLRPRQHQHQLFLDNENAIELDEEPRIINTTINNSNNHNSSRVDEDADDDIIFIKEQPIQFSSPLILPSSSSINNNNNIVTSNNPGCGTAATSNSTYITTPKKFKKQRTISLPQLPLSKLSYQSNYFNVPDQTNAIVPRVTQTENELLHLTGSCAKTLEGNKAVNLTIAHSTSPFSNPPAQIASLPQSNLKKQIGSSLRKFTSNGSSESASSNKSNFKTDKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSPSDLNSTVIKHFDRKTLSLQWPEKNKRGDTITTEKSMKRVLQSCDRLDIYISKVLKQDYGDSLSINWNLPPEKNWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALDHEWFNLGILDDGIATYNNTQG
What is the function of this protein?
Nonessential protein kinase.
What are the official names of this protein?
Dual specificity protein kinase KNS1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
Protein: ECD_HUMAN
Sequence: MEETMKLATMEDTVEYCLFLIPDESRDSDKHKEILQKYIERIITRFAPMLVPYIWQNQPFNLKYKPGKGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEFPELVARIEDNDGEFLLIEAADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWLPTTPPTIPQALNIITAHSEKILASESIRAAVNRRIRGYPEKIQASLHRAHCFLPAGIVAVLKQRPRLVAAAVQAFYLRDPIDLRACRVFKTFLPETRIMTSVTFTKCLYAQLVQQRFVPDRRSGYRLPPPSDPQYRAHELGMKLAHGFEILCSKCSPHFSDCKKSLVTASPLWASFLESLKKNDYFKGLIEGSAQYRERLEMAENYFQLSVDWPESSLAMSPGEEILTLLQTIPFDIEDLKKEAANLPPEDDDQWLDLSPDQLDQLLQEAVGKKESESVSKEEKEQNYDLTEVSESMKAFISKVSTHKGAELPREPSEAPITFDADSFLNYFDKILGPRPNESDSDDLDDEDFECLDSDDDLDFETHEPGEEASLKGTLDNLKSYMAQMDQELAHTCISKSFTTRNQVEPVSQTTDNNSDEEDSGTGESVMAPVDVDLNLVSNILESYSSQAGLAGPASNLLQSMGVQLPDNTDHRPTSKPTKN
What is the function of this protein?
Regulator of p53/TP53 stability and function.  Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345).  May be involved transcriptional regulation.  In vitro has intrinsic transactivation activity enhanced by EP300.  May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932).  Involved in regulation of cell cycle progression.  Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839).  The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270).  May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
What are the official names of this protein?
Protein ecdysoneless homolog, Human suppressor of GCR two, hSGT1.
What is the protein family that this protein belongs to?
Belongs to the ECD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly is located in the cytoplasm.
Protein: UPP_BRADU
Sequence: MEGVTIVDHPLVQHKLTLVRDKSISTKSFRELIKEIGMLLCYEVTRDLPLADTVIETPLATMHSAKIAGKKLVFVPMLRAGTTFVDGMMDLVPTARVAHIGLYREPHSFAAVEYFFKSPSDLGERLAIVVTPVVATANTAVAAIDRLKERGAKDIRLACLIAAPEGLERLRGLHPDVPIWTAAVDEGLDENGFILPGLGDAGDRAYGTR
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RL30_RHOJR
Sequence: MAELKVTQIKSTIGTKQNQRNSLRTLGLKGIRQTVVREDNAQNRGLINVVRHLVTVEEV
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.