Protein: LUBEL_DROME
Sequence: MTTHQLLNKNVRTMPSWVMEANDRIGPKPPPTPPNGVAGGLPKAPALPPKAKSTPEPDYEIIEFSSQQYSNEPMKTTVIRTKTPDNKLKCTLCGSQNPWVTCAECAGQIFCASCDDMFHKHPKRKQHMRKAVEQGTPPIPPKAQAGGGAPPPVAPPRRSKRGLLTPFLGRKDQMLPPPSPTPSHKSLGGWRGSLGGGATPPVPPIATSSANQMNNRPLPDPPRSEGGGSSRSGTPKSVFDTIQRPPSVQLEKIKSKASATLDRMAILQQRYRQQKARQDLSANSEQHLSNEAGFEHWSNISPSPSHFRSGSMSSGLNSSHFDLSDDSQFHNSLLLQQRQAAGAQRRQMSTSVFNLNSNPRRPLSEAQNGGAWLANQRIQQAQSLAQLNCAGCQQSQQHPGWAQHPHQALPQHQHPDQWSQFGSQQQFNNSNLSLNVGPGYMSQQHHPHYPPPVFMTQRGMMPNVYPGAPGYPMMHPGVMGMPPSAASRAASRSRYAASPTPSRKSMSLRRKRNSYVDDELTDDEDSDQDDRRSLVSNRSGMTSASRSQHHQNHIQPRQRRLSSASQLIASDELDGDQVHHKMRNRRGSIAKSVQSEWLPERRENEGTLTRNKTATDSARTSRIYSDLESEGSGARALVQAKIQQKLQEADQHKSSKKAEPKRKPEMKDENTQAAAVVQKVVVPPAHEESASEYEEVVEEVTASESEAEAQTAPDPQEVPDEIGADDLGPPPSTPDHEWECEFCTFVNEPNIKICSICCKTPSKPPVQPNKAKKVEEKPQPPAEKSNNIKASSKTETKPVQKPTTKSQQPSQKSVAALSKTTHTNSTSSSKASPAVNSKTTSSIPIKTPSKSTLKTSSENESDNSLAKSLLHKESVENIWNTLDESIQAQAEQVLKKAQKVSTACGGTPPREIAAVEMGTSPPPQSISTQTYDALPFNTKQEEIIPVVPDRFTTPEPNKMERRPHYRSNSQLQQESERYRSANDLRYHDGFGLDPYSAGLVTKRPNFINELRMLQLQVSSPFDMPHETFGVKHEPARDPETEMHIILKELELYKFTVEELEAALKYCSPETHPIQWLRENWHKLVQTVQSLSTKYGQERGENTIGTVSQNEAREALRNSGGNVWQAVADCIQQRQQKYRKLAAKGNFLRDDIVNALTAHQGNVEQALVELNRTQLKPFLMRIWGSPNGVENESGVAIDTKSDIHDFLNTHALDCLQPPLAGQSPSPAQANPFDQPRTDESPVKSTYATPSPYQMEDSTLKNLEILIGNMEQNQAKQNQEVLRSIETMLDTFKGKPELEYETDPEIMRILTKSPISTMKPSGPAEDKSTDDVKNFVWQHIQEIVPNLVQQVEQELMEKPEEVAKIEAEQPKEPEPLLEPQPEPTPSVDPAVYIMEEVIKPNLREASIREEVQPSFIYATEIANFKLEFDRGTERWHEAEWESSDLTDAERIVYKCYMAPNEQPKEDVVDVAVESSVNSLPTAKAQEESAPEVPIEAQKIENTEVTQPETVNEELRQQEKLETPLVITSETISETVSQTANESDKQKSIENNLQIKQNVAEVQVQSDDQPSTSRDANRRAKRSQQSRKGRSREQSQKPTNRTKLPNNIDQKVNESKTAAKETEAVKDKDLSAAASNIQSDVTASDPKTSTPLKILSEGTNSNTLETMENVTSTDINDNVTIEVISNRSEEVPAIQDLGKTKDISEPTANPIEEITSIQNSTTISEQSEGPQEPEIPIEVSETTEALQVPREEASIEIVSPPNEEQTKSPTSQEVNIQDTSHIISLPITDVTPTPEIINIAPSTSSISKEQKQSPKRLSKIPVRTLSSSSLRSESRSSNRTPTANDEIEREETTSQGVPIGETVSSPKSEQLSDNQEVNLVSQETQSKKDTNIVEEPATQPLGLELEEHSPNATAVAVSPTDSDEVFEDAPEFSGSDGTRPHDETASDAELYSLDSDGQRAETKSPEDEVVILLDEESQMESSIAQSESNASLDSHSSESETSKVVLKEFVPSGDPAKQNLSELVEDTQRLIKQMRDEISMDEFESTDEDEYSDEYSDEYDEGEEEEWYDSEGEEEGDFDGEEGNTYNEHASYIEEASTGDEGTEIEDIMEEDEDLADDDEPLQSQIPLDIEPVISPALSVTPTNQETDTIAHTEVVSSTGTRLETELPNPAMESILPSQSVQEDIKVEAIPIQSAPPIADSETRPAEQPVELVLEIPSEVEPTPVEEPTALPITPAPPIVDSESRPVEPPVETVLEEPKKVTPSMKGKTANSGTASKGPSTSSSTKTNKSTVSKIPKPTNEPTNKSNSTPLNKKVPLRSKSFSAPMGISSVKRIQEVYLQKQSSSIATSRVPLKSSPVTKKSINDAISRFNSNQADGPSTSGAAAAAAAALLKPRSQPRIPKKKYHETCFSDDDYETSATEEEQEEPNLAEPQKAEQLKRKMSMPVFRAYPSVQEPVIEDPAILARKYVDQELVTNIAEAQIAATLVSMKFSEDVALWAARECSDLDQAIAMLQQECELCMNSYPMNQMVSMLKCLHKCCKQCAKSYFTVQITDRSINDCSCPFCKLPELSNEAQHEDEHLEYFSNLDIFLKSILDNDVHELFQRKLRDRSLLQDPNFKWCIQCSSGFFARPKQKRLICPDCGSVTCAQCRKPWERQHEGSSCEAYLEWKRENDPELQAQGVQEHLAQNGIDCPKCKFRYSLARGGCMHFTCTQCKFEFCYGCARPFMMGAKCTVSTYCAKLGLHAHHPRNCLFYLRDKIPLQLQFLLKEQNVKFDTEPMQIKDESSSSSKARAQARCPIPLQKETPQGLVDTVCNTEVPDKHAGMCRTHYVEYLAGKVAKAGIDPLPIFDLTDCVQELRRRGIALPERGPWDTDEIYKNMCSEVIKKHIPLKSA
What is the function of this protein?
E3 ubiquitin-protein ligase which conjugates linear 'Met-1'- and 'Lys-63'-linked polyubiquitin chains to substrates and plays a crucial role in the NF-kappa-B intestinal inflammatory response to oral infection and in the heat stress response (PubMed:27702987, PubMed:30026495).  Preferentially interacts with 'Lys-63'-linked, and to a lesser extent 'Lys-48'-linked, polyubiquitin chains (PubMed:27702987).  Upon oral infection with a Gram-negative bacterium E. carotovora subsp.  carotovora 15, functions with the E2 ubiquitin-conjugating enzyme Ubc10 to mediate the conjugation of 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains to the substrate key which is essential for activation of the NF-kappa-B signaling cascade in the adult intestinal epithelium (PubMed:27702987, PubMed:30026495).  It is not required for systemic immune response to septic infection with either E. carotovora subsp.  carotovora 15 or Gram-positive M. luteus bacteria (PubMed:30026495).  Function in controlling linear ubiquitination is also essential for regulating the heat stress response in adults.  This function may require the E2 ubiquitin-conjugating enzymes Ubc10 or eff (PubMed:27702987).
What are the official names of this protein?
E3 ubiquitin-protein ligase lubel, Linear Ubiquitin E3 ligase.
What is the protein family that this protein belongs to?
Belongs to the RBR family.