PharMolix/UniProtQA huggingface dataset:
Protein: PAM17_CRYNJ
Sequence: MSRSVFSTLRPVIGQKTTLAPFAFSLRHASSSSSPFSTPTEPTSFHTQPSHSTPTGPLPLTWPSYLSLRRQRRLWSTLTSVPTTFLGLFLGGGYFASLEADPSQLIFGVEPMFVYGGATLGCMALGYLIGPSVGATLFSLTHPSIARGNPAPLEVMDREFYHRIRKNRADPRFQSVQNIVPDFYGEKIVSLSTYRRWLRDQAVYKRKAMHGVPGEDL
What is the function of this protein?
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
What are the official names of this protein?
Presequence translocated-associated motor subunit PAM17, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PAM17 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EIF3M_DROWI
Sequence: MTSHPVFIDLSLDEQVQELRKYFKKLGAEISSEKSNKGVEDDLHKIIGVCDVCFKDGEPAQIDGILNSIVSIMITIPLDRGENIVLAYCEKMTKAPNQPLAKVCLQSLWRLFNNLDTASPLRYHVYYHLVQVAKQCDQVLEVFTGVDQLKSQFANCPPSSEQMQKLYRLLHDVTKDTNLERSSKVMIELLGTYTADNACVAREDAMKCIVTALADPNTFLLDPLLSLKPVRFLEGDLIHDLLSIFVSEKLPAYVEFYEEHKEFVNSQGLNHEQNMKKMRLLTFMQLAESNAEMSFEALTKELQITENEVEPFVIEVLKTKLVRARLDQANRKVHISSTMHRTFGAPQWEQLRDLLQAWKENLSSVREGLTNVASAQLDLARSQKLIH
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit M, eIF3m, Transport and Golgi organization protein 7, Tango-7.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit M family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus.
Protein: 3SUB_DENAN
Sequence: RICHSQMSSQPPTTTFCRVNSCYRRTLRDPHDPRGTIIVRGCGCPRMKPGTKLECCTSDKCNV
What is the function of this protein?
Blocks M2 muscarinic acetylcholine receptors (CHRM2).  Fully blocks the binding of N-methylscopolamine (NMS) and oxotremorine-M to M2 receptors, slightly increased NMS binding to M1 receptors.
What are the official names of this protein?
Muscarinic toxin 2, m2-toxin.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type B muscarinic toxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MCA1B_NEOFI
Sequence: MYHRHSAPPPPGRSRGYPPPQQQWPPQPYQYLPYPPQGPPPAHTFPPPAHRSYPSPYPTPPPHSPSPYQYPHHGHSQSWSAPALPPRPPLEAQQFGNGAPSHYRFQYSACTGRRRALLIGINYIGQPNQLRGCINDVTNMSTFLHERYGYRREDMVILTDDQKNPLSIPTKANILRAMQWLVKDAQPNDSLFLHFSGHGGRTPDLDGDEEDGYDDVIYPVDYRVAGHIVDDEMHNIMVRPLRPGVRLTVIFDSCHSGTALDLPYVYSTQGILKEPNLAKEAAQDLFSAISSYGKGDLSGVAMTAIGFLKKAAKGDSARKRTVMTKTSPADVVMFSGSKDTQTSADTFQDGEARGALSWAFIKSLRQWPNQSYLQLLNSIRAQLEGKYTQKPQLSCSHPLGAWVMRAIEEPA
What is the function of this protein?
Involved in cell death (apoptosis).
What are the official names of this protein?
Metacaspase-1B.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
Protein: SAPK7_ORYSJ
Sequence: MERYELLKDIGAGNFGVARLMRNKETKELVAMKYIPRGLKIDENVAREIINHRSLRHPNIIRFKEVVVTPTHLAIVMEYAAGGELFDRICNAGRFSEDEARYFFQQLICGVSYCHFMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSLLHSKPKSTVGTPAYIAPEVLSRREYDGKTADVWSCGVTLYVMLVGAYPFEDPDDPKNFRKTIGRIMSIQYKIPEYVHVSQDCRQLLSRIFVANPAKRITIREIRNHPWFLKNLPRELTEAAQAMYYKKDNSAPTYSVQSVEEIMKIVEEARTPPRSSTPVAGFGWQEEDEQEDNSKKPEEEQEEEEDAEDEYDKQVKQVHASGEFQLS
What is the function of this protein?
May play a role in signal transduction of hyperosmotic response.
What are the official names of this protein?
Serine/threonine-protein kinase SAPK7, Osmotic stress/abscisic acid-activated protein kinase 7, RK4 kinase, stress-activated protein kinase 7, OsSAPK7.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HIS6_BURA4
Sequence: MALAKRIIPCLDVTAGRVVKGVNFVELRDAGDPVEIARRYDDQGADELTFLDITATSDQRDLILPIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVSMNSSAVANPQLVRDAADKYGSQCIVVAIDAKRVSADGETPRWEVFTHGGRKNTGLDAIEWARRMAELGAGEILLTSMDRDGTKSGFDLALTRGVSDAVPVPVIASGGVGSLQHLADGIKDGRADAVLAASIFHYGEHTVGEAKRFMSDQGIPVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPTR_STAAC
Sequence: MFKVVICDDERIIREGLKQIIPWGDYHFNTIYTAKDGVEALSLIQQHQPELVITDIRMPRKNGVDLLNDIAHLDCNVIILSSYDDFEYMKAGIQHHVLDYLLKPVDHAQLEVILGRLVRTLLEQQSQNGRSLASCHDAFQPLLKVEYDDYYVNQIVDQIKQSYQTKVTVSDLIQHIDVSESYAMRTFKDHVGITIVDYLNRYRILQSLQLLDRHYKHYEIADKVGFSEYKMFSYHFKKYLQMSPSDYCKQAK
What is the function of this protein?
Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources.  Activates uhpT expression to facilitate glucose-6-phosphate/G6P utilization by directly binding to its promoter.  Antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility.
What are the official names of this protein?
Transcriptional regulatory protein HptR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_AMAHP
Sequence: MSPQTETKASVGFKAGVKDYRLTYYTPEYETQDTDILAAFRVSPQPGVPPEEAGAAVAAESSTGTWTSVWTDGLTNLDRYKGRCYNIEPVAGEENQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLSQYCRDNGLLLHIHVAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDYTEKDRCRGIFFTQSWVSTPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNTIIREAAKWSPELAAACEVWKEIKFEFPAMDTI
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLN1B_SYNY3
Sequence: MARTPQEVLKWIQDENIKIIDLKFIDTPGIWQHCSFYYDQLDENSFTEGIPFDGSSIRGWKAINESDMCMVPDPNTATIDPFCKEPTLSMICSIKEPRTGEWYNRDPRTIAAKAVEYLRGTGIADTVYFGPEAEFFLFDDIRFGQTENSSYYFADSVEGRWNTGREEEGGNLGYKPGYKQGYFPVAPTDTAQDIRTEMLLTMAGLCVPIEKHHHEVASGGQNELGIKFDKLVNSADNLMIYKYVIKNVAKKYGKTVTFMPKPIFNDNGSGMHVHQSLWKDGQPLFAGDKYAGFSQMGLWYIGGILKHAPALLAFTNPTTNSYKRLVPGFEAPVNLAYSQGNRSASVRIPLSGGNPKAKRLEFRCPDATSNPYLAFAAMLCAGIDGIKNQIDPGEPLDVDIYDLSPEELAKIPSTPGSLEAALEALEKDHEFLTGTGVFSPDFVESWIEYKLDNEVNPMRLRPHPYEFSLYYDC
What is the function of this protein?
Involved in nitrogen metabolism via ammonium assimilation (PubMed:8002575).  Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia (PubMed:1973929, PubMed:8002575).
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I beta, GSI beta.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG2_BACHK
Sequence: MKKIVFTGGGSAGHVTPNLAIIPYLKEDNWDISYIGSHQGIEKTIIEKEDIPYYSIASGKLRRYFDLKNIKDPFLVMKGVMDAYVRIRKLKPDVIFSKGGFVSVPVVIGGWLNRVPVLLHESDMTPGLANKIALRFASKIFVTFEEAAKHLPKEKVIYTGSPVREEVLKGNREKALAFLGFSRKKPVITIMGGSLGAKKINETVREALPELLRKYQIVHLCGKGNLDDSLQNKEGYRQFEYVHGELPDILAITDFVISRAGSNAIFEFLTLQKPMLLIPLSKFASRGDQILNAESFERQGYASVLYEEDVTVNSLIKHVEELSHNNEAYKTALKKYNGKEAIQTIIHHISEA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TRHO_ANAPZ
Sequence: MLMSMGFVVAAFYRFVHLHNYYDMRSVILEFCQEHGIKGTVILAEQGINATISGERDAINKFFSFLDLDHRLADMKYHESYSSRLPFSKMKVRLKKEVVRLGIDDFDCSSMRGEYVDPKAWNDLITKPGMHVIDTRNDYEIKFGRFKHSINPGTTSFREFPDWARKWAEGKDKDVGVAMYCTGGIRCEKSTAFLKSLGFENVYHLKGGILNYLQSVKGADSLWEGDCFVFDERVAVDNNIAPSEDIKCVKCFGKVDEADLRSVSKGHIVCGACKSADVS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: DPOD2_ARATH
Sequence: MEIDSEKIHERKQSDYNSLDERFEIQKEMYRGQQYSQIYFARLHLMRTLLYSLAPTWKSHLPVCKVLGLEKGKECIIVGTLFKHMKLKPCVLDEYSKERSVTPLVKPHNFMHPDDNLILEDESGRVKLAGSALSPAIYVTGVVVALHGKETNAGEFFVEDVLEAGLPPQIERPIDLQEDKYVVLLSGLCIGSKSANPLQFQLLVDHITGHLGDEEEQGLAAQIVHVVIAGNSFEFPRKLINGQNLASKDQSTLYEPIKELDIMLSQIAAGVSVDIMPGTNDPANFALPQQPLNRCLFPGSSPYNTFRSCTNPHSFDVDNIRFLGTSGQNIDDLGKYSEAKSKLDFVERTLRWRHLAPTAPNTLGCYPFTDRDPFLIETCPHVYFVGNQDKYDNRLIKGSEGQLVRLICIPKFCETGIAVAVNLRNLECHTLSFSTQINQS
What is the function of this protein?
The function of the small subunit is not yet clear.
What are the official names of this protein?
DNA polymerase delta small subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase delta/II small subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NCBP2_DROWI
Sequence: MSNSVELSSYRDQHFKGSRSEQERSLKESCTLYVGNLSFYTTEEQIHELFSRCGDVRLIVMGLDKYKKTPCGFCFVEYYTRSEAESAMRFVNGTRLDDRLIRVDWDAGFIEGRQYGRGKTGGQVRDEYRTDYDAGRGGYGKLLSQKIAPNTDNR
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CGL_DICDI
Sequence: MTQPNNYKIGTNVIHAGQSADKNTGAVIVPISLSTTFLQPSPGVLHSEYDYSRSGNPTRKAFEECIAACENAKYALSFASGLATLTTITHLLKSGDEVISIDDVYGGTRRYFTRVAANFDLKFSFVDLSTLDDLKNAFTDKTRLVWIETPTNPLLKVADIKAVADYVHSRGATLVVDNTFMSPYFQNPLDLGADIVMHSVTKYINGHSDCVMGVLATNNDELYAKLKFLQNSIGAVPSPFDCFLALRGLKTLHVRMEAHQKNAFAICNFLEKHPKVERVIYPGLPSHPQHEICKRQMKGYGGMVVFFVKGSIDQSRSFLENIKLFALAESLGGVESLIELPSVMTHASVPAEERAKLGISDTLIRLSVGIEDINDLLADISQALDKC
What is the function of this protein?
Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate.  Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione.  Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S).
What are the official names of this protein?
Cystathionine gamma-lyase, CGL, CSE, Cysteine desulfhydrase, Cysteine-protein sulfhydrase, Gamma-cystathionase, Homocysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Z687A_DANRE
Sequence: MGDMKTPDFDDLLAAFDIPDIDAKEAIQSDTHGNHNEHSSVVGKERSGSPSLRPSGSPDPPHNDPSVVSVIVKNSVHSDDKAEGNETGEFSSADESQKSPQKGPSKDSSVPTDPFIYNGLKSVSDGSTESPPSLDLAPGQHNGPLWSLSASKATGDDDKHNDAFTNHPASTFQSLPLSNHPSVSSHLISPNFSSKVDSEEAQAINGTLRAGVRRHQSEDEESEPDLGSPALVIQESPISQLCPAPKVPRMQRSPSSVFQPPSPSSPSLPVSNTQMEEPSVQHPKLHSSTNPTSLTSTNNLPVEEKDLEHIIEERDSPESPEPEISQSRTSLPSNSQGAIESKQRITREEAPQDEVMDVSMQEKVDYGAEATEGKSTEPTLVESASDAISNSASSKPLKMRIKTVKKPVVSITRTVSKAATKGGASKGSGASKVQAVARKSLQKIPRSVASPQLLSQSTKVAMLPVSTLQDASTAMLFAASRAQNQMPTALSATAVNITRTSNLPSISSSSIPGVNVRAASGQKTNTGTAKPASIVNSPGAVISRSQSSLVEAFNKILNSKNPLPSYQPDLTSLPPPEWGLRLPSTGYRCLECGDAFALERSLARHYDRRSMRIEVTCNHCSKRLAFFNKCSLLLHAREHKEKGLVMQCSHLVMSPVSVEQMIGQQDTVPIGVLSPAVSALSAIKESGVNLSQSSDHSCPECWSTFKGKQELVAHFQEVEPGGTDTCCLQCSPPMPLWNSCCAAAHRRMHQQLPPLVCPECGLICQTHELNTHLKQTCLHYSRRLGYKCACCHLVFGGVNSQNAVKTHMQTAHCEIFHKCPSCPMAFKSSSGAESHCASQHPELSESARQSKEIYKCVMCRTVFTQKSLLSVHIDTHLTKQKMHVFKCPDCNKLFTQRTSLLEHVKDTHRETSNHDGTSTQNSLVKMESSDGEEWGRDEEEDKGKVSDANSAVPRSQSWSCSQCQTHYTDKENYISHMTEQHGKELKKFPCTLCEGSFSSSSSLRRHIRVKHKGIKRVFYCQLCTGEKRSFSSKLILEKHIQAQHAGERGTATQSQAVPQFTDGADSSSEHDAGVLGGSSVEPESRLAESTLTRRIKGAPVGEQEAKGLRCMPCGFTTEDREEFLQHIVCHRDGGSGAQCQQCGACFASSSSLSRHLFISHRVRDSPSDHAEAALHTCATSVASDSAAAGGSPGSPLSVVGGLLEDGEGKHICKVCGRYFSKPADLNTHFRTHGMAFITAYKTDKPA
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 687a.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATP8_LYCSM
Sequence: MPQLDTIYILMTHLWAWLMLYLTTQKIKTFIMTSHPMIYHKPNKQTPTPTWL
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: FGFR4_RAT
Sequence: MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.  Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.  Phosphorylates PLCG1 and FRS2.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation.  FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 4, FGFR-4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
Protein: DER_ACTP2
Sequence: MTPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGHANIAGYDFIVIDTGGIDGTEEGVEEKMAEQSLLAIEEADVVLFLVDARAGLVPADIGIAQYLRQREKTTVVVANKTDGIDADSHCAEFYQLGLGEVEQIAAAQGRGVTQLIDQVLAPLGEQLNADQAVENEENSANEEADEWDTDFDFENEDDTALLDEALEEETEESIEDKNIKIAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDGQQYTIIDTAGVRKRGKVNLAVEKFSVIKTLQAIQDANVVLLTIDAREGISDQDLSLLGFILNAGRSLVIVVNKWDGLSQDIKDQVKSELDRRLDFIDFARVHFISALHGSGVGNLFDSVKEAYACATQKTSTSMLTRILRMAADEHQPPLVNGRRVKLKYAHPGGYNPPIIVIHGNQVEKLADSYKRYLSNYFRKSLKIIGSPIRIQFQEGNNPFAGKKNKLTPNQLRKRKRLMKFIKKSKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: OFP9_ARATH
Sequence: MALVMLARAPAPPLLLPSPNPPPCALPQDLTSLVSPSEPPDPPDPPDYLVGASNSFLSILLLRSSDLGSDLVQALSPLDLGFALRSITAVCSSWYQVFPLACLELWFSIPHLSHPLVTLSKGFVSLKGSNFFEFFTFFWNMPSFILQFPHHEDVMISTSFRLVLPQYEAVMILLKLKLFLPHYEDVLFSIGLRIQLLLPQYEVGLILYKLRLLLPHYEDVIQKLWLRAIHVIVSLVWFLEISRRIKEKTYDVLTRNDLGSWTPDLFIEKWWFSQPHTSPKLRFFSHLVGSRNHHGSLSSLAHYMVQEKLEQMIRETQEATHQEKIRQQKMRRRRRRSEGSISSTKFIVMMAMEKCSFDPRKDFRDSMVEMIVANKIKEADELRSLLEYYLSMNPREYRSAILEIFYEVCADLFRS
What is the function of this protein?
Probable transcriptional repressor that may regulate multiple aspects of plant growth and development.
What are the official names of this protein?
Probable transcription repressor OFP9, Ovate family protein 9, AtOFP9.
What are the subcellular locations of this protein?
Nucleus.
Protein: SHO1_ASPNC
Sequence: MARFRASNILGDPFALASTSISILAWLIAFISSIVTGVHGGYPTYSWWAVAYSFCCIVGMALVFGTDTGAVYNIAIVGYLSAGLVITTISINTLVYANSAASQAAGAGFILLAMVIIIWIFYFGSSPQASHRGFIDSFALQKEGAGSYGNGRPMSTAFGNRPETTSSQPPQMYTSAQLNGFETSSPVSGYPGGAPGSEHRSSSQPRFGNPSATNLPNNGAPDEVPQPTEYPYRAKAIYSYEANPEDANEISFTKHEILEVSDVSGRWWQARKATGETGIAPSNYLILL
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
What are the official names of this protein?
High osmolarity signaling protein sho1, Osmosensor sho1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y3197_PARPJ
Sequence: MDARLLEILVCPICKGPLSYDRAAQELICNADKLAYPIRDGIPVMLVDEARQTVEGTPVDLNPGSVA
What are the official names of this protein?
UPF0434 protein Bphyt_3197.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: RNP3_METM7
Sequence: MLEGIFDINHIFDEDGIKTLKRFGWDGSVAVQNHNEYSEEIINSAVEYGEKHDFKVFSGVKISTKNQNEMEKAVKKYRNKADILLVEGGDIKINRRVLEMNDVDILSTPELNRMDNGLDHILARLGSTNRVAIELNFGNLLKSRNYDRSKILWAFQRNLKLAKKYDTPVVISSGASDIYGIKAPGDLRGFLNTVTDPLYSKKIMETTSKIIDYRLYLKKDTVLTLGIEIVEE
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 3, RNase P component 3, Rpp30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UE38_DEIRA
Sequence: MKKFAAVLGLTVAFAAASQAHAVTLTFACDSVGQGFDECKKGADAWAKKTGNTVKLVQVPKESDARLALYQQQLGAKASDVDVYMIDVVWPGLIGQHLMDLSKSIPAAEVKAHFPAIVQNNTVGGKLIAMPWFTDAGVLYYRTDLLKKYGYNAPPKTWNELATMAQKIQAGERKSNPKFVGYVFQGKNYEGLTCDALEWISSFGGGSIVDPSGKITVNNPKAVQALQAIQGLIGTAAPAAVTTYGEEEARNVWQAGNSAFMRNWPYAYAAGQKEGSPIAGKIGVAALPAGPGGKPAATLGGWQLAVNAYSKNPKEAADLVRYLTGAQEQKRRAVQASYNPTIATLYKDKDVLKAVPFFGSLYDVFTNAVARPATVTGSKYNQVSDAFSSAVYSVLTKKSAPGPALKTLEGQLARIKGRGW
What is the function of this protein?
Probably part of a binding-protein-dependent transport system.
What are the official names of this protein?
Probable ABC transporter-binding protein DR_1438.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
Protein: SUT1_ORYSI
Sequence: MARGSGAGGGGGGGGGGLELSVGVGGGGGARGGGGGEAAAAVETAAPISLGRLILSGMVAGGVQYGWALQLSLLTPYVQTLGLSHALTSFMWLCGPIAGMVVQPCVGLYSDRCTSKWGRRRPYILTGCVLICLAVVVIGFSADIGYAMGDTKEDCSVYHGSRWHAAIVYVLGFWLLDFSNNTVQGPARALMADLSGRHGPGTANSIFCSWMAMGNILGYSSGSTNNWHKWFPFLKTRACCEACANLKGAFLVAVIFLSLCLVITLIFAKEVPFKGNAALPTKSNEPAEPEGTGPLAVLKGFRNLPTGMPSVLIVTGLTWLSWFPFILYDTDWMGREIYHGDPKGTDPQIEAFNQGVRAGAFGLLLNSIVLGFSSFLIEPMCRKVGPRVVWVTSNFLVCIAMAATALISFWSLKDFHGTVQKAITADKSIKAVCLVLFAFLGVPLAVLYSVPFAVTAQLAATRGGGQGLCTGVLNISIVIPQVVIALGAGPWDELFGKGNIPAFGLASGFALIGGVAGIFLLPKISKRQFRSVSMGGGH
What is the function of this protein?
Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system).  May also transport other glucosides.  May be required for apoplastic phloem sucrose loading in source tissues (e. g.  leaves) in order to transport it to sink tissues (e. g.  roots, flowers) (By similarity).
What are the official names of this protein?
Sucrose transport protein SUT1, Sucrose permease 1, Sucrose transporter 1, OsSUT1, Sucrose-proton symporter 1.
What is the protein family that this protein belongs to?
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2.4) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.