PharMolix/UniProtQA huggingface dataset:
Protein: MTMR4_HUMAN
Sequence: MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNLNNHCQEVRVGLEPWHSNPEGSETSFVDSGVGGPQQTVGEVGLPPPLPSSQKDYLSNKPFKSHKSCSPSYKLLNTAVPREMKSNTSDPEIKVLEETKGPAPDPSAQDELGRTLDGIGEPPEHCPETEAVSALSKVISNKCDGVCNFPESSQNSPTGTPQQAQPDSMLGVPSKCVLDHSLSTVCNPPSAACQTPLDPSTDFLNQDPSGSVASISHQEQLSSVPDLTHGEEDIGKRGNNRNGQLLENPRFGKMPLELVRKPISQSQISEFSFLGSNWDSFQGMVTSFPSGEATPRRLLSYGCCSKRPNSKQMRATGPCFGGQWAQREGVKSPVCSSHSNGHCTGPGGKNQMWLSSHPKQVSSTKPVPLNCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQQLKKPIATASS
What is the function of this protein?
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate.  Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
What are the official names of this protein?
Myotubularin-related protein 4, FYVE domain-containing dual specificity protein phosphatase 2, FYVE-DSP2, Zinc finger FYVE domain-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.
Protein: BSAZ_BURTA
Sequence: MAEKTEKPTAKKLRDAAKKGQTFKARDIVALVVIATGALSAPALVDLTRVAAEFTRIASTGAQPNPGAYALAWAKLFLRIAAPFVLLCAAVGALPSLVQSRFTLAVESIRFDLTALDPVKGMKRLFSWRSVKDAVKALLYVGVFAITVRVFADLYHHDVFGLFRARPALLGHMWIVLTVRLVLLFLLCALPVLIVDAAVEYFLYHRELKMDKHEVKQEYKESEGNHEIKSKRREIHQELLSEEIKANVEQSDFIVANPTHIAIGIYVNPDIVPIPFVSVRETNARALAVIRHAEACGVPVVRNVALARSIYRNSPRRYSFVNQDDIDGVMRVLIWLKEVEAANRGGPPREMPPEATHAPDAHGGDAASGGATSAQAGERNA
What is the function of this protein?
Part of the bsa type III secretion system, is involved in the intracellular replication of invading bacteria inside the host cell.  Probably necessary for the lysis of the vacuole membrane and escape into the host cell cytoplasm (By similarity).
What are the official names of this protein?
Secretion apparatus protein BsaZ.
What is the protein family that this protein belongs to?
Belongs to the type III secretion exporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TXA1_LATGE
Sequence: MNKLFFVVFLCLIISVLAIGPADLGCTDMPQAEFDEKNANCEKCGNEEGFGEEMVSRCRDKCFTDNFYQSCVDLLNKVYEEKDVPVPPEE
What is the function of this protein?
May increase the toxicity of alpha-latrotoxin and/or other venom components.  Is non-toxic to mice and to the cockroach Periplaneta americana.
What are the official names of this protein?
Alpha-latrotoxin associated low molecular weight protein, Alpha-latrotoxin-associated LMWP, Latrodectin-1, Latrodectin.
What is the protein family that this protein belongs to?
Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
What are the subcellular locations of this protein?
Secreted.
Protein: CC50C_PANTR
Sequence: MEERAQHCLSRLLDNSALKQQELPIHRLYFTARRVLFVFFATGIFCLCMGIILILSARSTQEIEINYTRICANCAKLQENASNFDKECTCSIPFYLSGKMMGNVYMYYKLYGFYQNLYLYIRSRSNRQLVGKDVKVRLNLIWYNTLFLFLNQVDFSV
What are the official names of this protein?
Cell cycle control protein 50C, Transmembrane protein 30C.
What is the protein family that this protein belongs to?
Belongs to the CDC50/LEM3 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PDXY_PSEA7
Sequence: MPRTPHLLAIQSHVVFGHAGNAAAVFPMQRIGINVWPLNTVQFSNHTQYGRWTGQVLPPEQIPALVEGIAGIGELGNCDAVLSGYLGSAAQGRAILEVVGRIKQANPRALYLCDPVMGHPEKGCIVAPEVSDFLLEEAAAVADYLCPNQLELDSFCDRQPNSLADCVEMARSLLARGPRAILVKHLNYPGKAGDTFEMLLVAADQVWHLQRPLLAFPRQPVGVGDLTSGLFLSRLLLGDDLRNAFEFTSAAVHEVLLETQARGSYELELVRAQDRIAHPRVRFDAVRL
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: BIOF_XANCB
Sequence: MARPDLHERISSLRKLRVAQERVRVRRQVGRRDGVRLEIDGRWLTGFCSNDYLGLSQQFEVVAALQDAAARDGAGATASHLICGHHTAHETLERDIAEWLGYPSALLFGSGFIANLAVQQALLSEEDDVCVQDRLNHASLLDATRLAGCRLRRYPHLDVEGAMRQLKGAPEGAAMLASDGVFSMDGDVAPLRALSLVARMQEALFYVDDAHGVGVLGPQGRGCVADAGLGVAEVPLQLVTLGKALGGYGAVVVGEEALIRHLAETARPYIYTTALPPAQVAATLAAVRLARRDDWRRTRLTELIGTFRDGARRHGFELMASDTPIQPLLCGEEATVMAMSAALEQAGFLVGAIRPPTVPEGKARLRVTLSALHTPQQVQALVDAIVQARDVVSRQPQRALA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: GLRX1_SYNY3
Sequence: MANLFNWLPLLSGRQADGIKAKVEIYTWQTCPFCIRAKLLLWWKGVKFIEYKIDGDDQARQAMAARAEGRRTVPQIFVNDQGIGGCDQLYGLDSRGQLDPLLATPPNPA
What is the function of this protein?
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase.  Reduces low molecular weight disulfides and proteins (By similarity).
What are the official names of this protein?
Probable glutaredoxin slr1562.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
Protein: C7193_ESCCA
Sequence: MEEMKFLIMNNPWVLFATSATLLISIFLFFRRKSPNMAWPEGPKTLPIIGNMHLLGGTALQVVLYNLAKVHGRVMTIWIGSWRPVIVVSDIEQAWEVLVNKSSDYSARDMPDITKIVTADWRTISTSDSGPHWSNLRKGLQNIAISPNNLAAQFQFQEKDIIKMIQILEQEAKDNNGIVKPLDHLKKATIRLISRLVFGRDFEEDKYVEDMHHAIEELIRISGYARLAEAFYYAKYLPSHRKAVRYVEELKQIVKNLIRPFLSVNPPTNTYLHFLRSQNYDEEVVIFAIFETYLLGVDSTSSTTAWALAYLVREPSVQDRLHQELDHFAKQNDRKILKVEDMNKLQYLQAVIKETMRMKPIAPLAIPHKACKDTSLMGNKINKGTRVMVNLYALHHNKNVFNDPFKFMPERFLKVDNQDAKGKAMEQSLLPFSAGMRICAGMELGKLQFSFALANLIFAFKWSCVDDGVLPDMSDELGFVLLMKTPLKARINPRN
What is the function of this protein?
Methylenedioxy bridge-forming cytochrome P450 involved in the biosynthesis of isoquinoline alkaloids.  Converts (S)-cheilanthifoline to (S)-stylopine, (S)-scoulerine to (S)-nandinine and (S)-tetrahydrocolumbamine to (S)-canadine, but only the ring A (2,3-position) of the substrates is converted.  Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
What are the official names of this protein?
Trifunctional (S)-stylopine synthase 2/(S)-nandinine synthase/(S)-canadine synthase, STS, Cytochrome P450 719A3, EcCYP719A3, EcCYPA.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MET3_CHAGB
Sequence: MANSPHGGVLKDLLARDSPRHAELSTEAETLPALLLSERQLCDLELLLNGGFSPLEGFMTEQDYNGVVKENRLASGALFSMPITLDVDQATIDELSLKAGARITLRDFRDDRNLAILTVEDVYKPDKALEAKEVFGGDEEHPAVQYLYKTAKDFYVGGKLEAVNRLQHYDFVELRYTPSELRAHFDKLGWAKVVAFQTRNPMHRAHRELTVRAARSHHANVLIHPVVGLTKPGDIDHFTRVRVYKALLPRYPNGMAVLGLLPLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGKNSKGVDFYGPYDAQYAVEKYRDELGIEVVPFQMMTYLPDSDEYAPVDQIPQGVRTLNISGTELRARLRSGREIPEWFSYPEVVKVLRESHPPRSQQGFTIFLTGYQNSGKDQIARALQVTLNQQGGRSVSLFLGETVRHELSSELGFSREDRDKNIARIGFVASELTRSGAAVIAAPIAPFEQARQSARELVEKYGDFYLIHVATSLEYCEKTDKRGIYKKARAGEIKGFTGVDDPYEAPAKPNLVVDAETQSVRSIVHQIILLLESQGLLDRF
What is the function of this protein?
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.  Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the APS kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD93_HUMAN
Sequence: MGLPRGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCNFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSVSQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRRKYKRHQGAEELLDEESRIHATLLEYGRRYGFSRQSKMEKAEDKKTALPAGLSATEKADAHEEDELRAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSAEIKQIVSEYAEKQSELSAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTYSEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFKAHCREEMTRLQQEIENLKAERAPRGDEKTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKEISLLNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKNEMLLSKVKAKAS
What is the function of this protein?
(Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.
What are the official names of this protein?
Coiled-coil domain-containing protein 93.
What is the protein family that this protein belongs to?
Belongs to the CCDC93 family.
What are the subcellular locations of this protein?
Early endosome.
Protein: ENO_STAHJ
Sequence: MPIITDVYAREVLDSRGNPTVEVEVLTESGAFGRALVPSGASTGEHEAVELRDGDKSRYSGKGVTKAVENVNEIIAPEIVEGEFSVLDQVSIDKMMIQLDGTPNKGKLGANAILGVSIAVARAAADLLGQPLYKYLGGFNGKQLPVPMMNIVNGGSHSDAPIAFQEFMILPTGAESFKEALRWGAEIFHNLKSILSERGLETAVGDEGGFAPKFEGTEDAVETIIKAIEKAGYKPGEDVFLGFDCASSEFYENGVYDYTKFEGEHGAKRSAAEQVDYLEELIGKYPIITIEDGMDENDWDGWKQLTDRIGDKVQLVGDDLFVTNTEILSRGIEQGIGNSILIKVNQIGTLTETFEAIEMAQKAGYTAVVSHRSGETEDTTISDIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELFETAKFDGIKSFYNLDK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RBM41_HUMAN
Sequence: MKRVNSCVKSDEHVLEELETEGERQLKSLLQHQLDTSVSIEECMSKKESFAPGTMYKPFGKEAAGTMTLSQFQTLHEKDQETASLRELGLNETEILIWKSHVSGEKKTKLRATPEAIQNRLQDIEERISERQRILCLPQRFAKSKQLTRREMEIEKSLFQGADRHSFLKALYYQDEPQKKNKGDPMNNLESFYQEMIMKKRLEEFQLMRGEPFASHSLVSATSVGDSGTAESPSLLQDKGKQAAQGKGPSLHVANVIDFSPEQCWTGPKKLTQPIEFVPEDEIQRNRLSEEEIRKIPMFSSYNPGEPNKVLYLKNLSPRVTERDLVSLFARFQEKKGPPIQFRMMTGRMRGQAFITFPNKEIAWQALHLVNGYKLHGKILVIEFGKNKKQRSNLQATSLISCATGSTTEISGS
What is the function of this protein?
May bind RNA.
What are the official names of this protein?
RNA-binding protein 41, RNA-binding motif protein 41.
Protein: SPS1_DROME
Sequence: MSYAADVLNSAHLELHGGGDAELRRPFDPTAHDLDASFRLTRFADLKGRGCKVPQDVLSKLVSALQQDYSAQDQEPQFLNVAIPRIGIGLDCSVIPLRHGGLCLVQTTDFFYPIVDDPYMMGKIACANVLSDLYAMGVTDCDNMLMLLAVSTKMTEKERDVVIPLIMRGFKDSALEAGTTVTGGQSVVNPWCTIGGVASTICQPNEYIVPDNAVVGDVLVLTKPLGTQVAVNAHQWIDQPERWNRIKLVVSEEDVRKAYHRAMNSMARLNRVAARLMHKYNAHGATDITGFGLLGHAQTLAAHQKKDVSFVIHNLPVIAKMAAVAKACGNMFQLLQGHSAETSGGLLICLPREQAAAYCKDIEKQEGYQAWIIGIVEKGNKTARIIDKPRVIEVPAKD
What is the function of this protein?
Plays a role in apoptosis and consequently a role in imaginal disk patterning and growth.
What are the official names of this protein?
Inactive selenide, water dikinase-like protein, Protein patufet, Selenophosphate synthetase 1.
What is the protein family that this protein belongs to?
Belongs to the selenophosphate synthase 1 family. Class II subfamily.
Protein: IMAND_STRSH
Sequence: MASSAHSDSASSDAPAELPAEILAAAPWSAPADDSEHLRITAVRTFLTAPQGCPYVIVRVETNQPGLYGLGCASDPQRTLAIRSVVDDYYAPMLLGRDPADIEDLHRLLFNSGYWRGGSIGQNALAGVDVALWDIKGKVAGLPLHQLLGGRAREAAEAYTHVDGDNAGEIAEKVLAAHERGYRHVRVQVSVPGTDTYGTAPRDAAEARRRELRAGSWDSLAYLRHVPPVLREIRERVGTGVELLHDAHERLTPSQARELVHEVEDARLFFLEDALAPEDAAHFDQLRAAGSVPLAVGELYHDVMMYLPLLQRQVIDFARIRVPTLGGLTPTRKLVAAVELFGARTAPHGPGDVSPVGMAANLGLDLSSPAFGVQEAATFREPTREVFPGTPVPERGRFHGSDRPGLGVDFDEVAARKYPVPEPLRHDRWALLRNGDGSVQRP
What is the function of this protein?
Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding.  May have evolved a divergent function.
What are the official names of this protein?
D-galactonate dehydratase family member SSBG_02010.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: PNP_BACAH
Sequence: MSQEKQVFSIDLAGRQLTVETGQLAKQANGAVLVRYGDTAVLSTATASKEAKNVDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAILASRLIDRPIRPLFADGFRNEVQVVSIVMSVDQDCSSEMAAMLGSSLALSISDIPFEGPIAGATVGRINGEFVINPTVEQQEQSDIHLVVAGTKDAINMVEAGADQVPEETMLEAIMFGHDEIKRLIAFQEEIVQAVGKEKSEVKLYEVDADLNQAVREMAEKDMHSAIQVHEKHAREDAINEVKKRVIEHYEAQEADADTLGQVNEILYKIVKEEVRRLITVEKIRPDGRKGDEIRPLASEVGILSRTHGSGLFTRGQTQALSICTLGALGDVQILDGLGVEESKRFMHHYNFPSFSVGETRPMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICGSTLAMMDAGVPLKAPVAGIAMGLVKTGEHYTILSDIQGMEDHLGDMDFKVAGTAHGVTALQMDIKIDGLSREILEEALQQAKVGRVHILNHMLSVIAEPRTELSAYAPKIITMTINPDKIRDVIGPSGKQINKIIEETGVKIDIEQDGTVFISSINQEMNDKAKKIIEDIVREVQVGEIYEGKVKRVEKFGAFVELFSGKDGLVHISELALERVGKVEDVVKIGDVITVKVIEIDKQGRVNLSRKVLLKEEQEKEAAKEENKQEQQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEVI_XENLA
Sequence: MYKGIFLCVLFAVICANSLAKPSSDADEDNDEVERYVRGWASKIGQTLGKIAKVGLQGLMQPKREAMLRSAEAQGMIGTLTSKRIKQG
What are the official names of this protein?
Prolevitide.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MMP16_RAT
Sequence: MILLAFSSGRRLDFVHRSGVFFFQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRDKEGLSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
What is the function of this protein?
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin.  Activates progelatinase A.  Involved in the matrix remodeling of blood vessels.  The short isoform efficiently converts progelatinase A to the intermediate form but not to the mature one.  It has no effect on type I, II, IV and V collagen.  However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
What are the official names of this protein?
Matrix metalloproteinase-16, MMP-16, Membrane-type matrix metalloproteinase 3, MT-MMP 3, MTMMP3, Membrane-type-3 matrix metalloproteinase, MT3-MMP, MT3MMP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the cell surface of melanoma cells. SUBCELLULAR LOCATION: [Isoform Short]: Secreted, extracellular space, extracellular matrix.
Protein: MQO_ACIB3
Sequence: MKKFLKYLLVLIILILIAGIVFLFRPIASKQVQTAKDEPVVDAVLVGGGIMSATLGTYFTELEPNWQIRMYERLDQVAQESSNGFNNAGTGHSGFMEMNYTEEKNGKMEIAKAEKVASQFEVAKQFWSYQVKQGVLAEPKTFINPVPHIAFVWGDNVKFLEKRYAAMIQSPLFKGMKFTEDPAVIKQWAPLVMTDRDPTQKVAATRMEVGSDVNYGSITKQLVNHLNQNPNFKLQTSTEVTGISQNDDKTWTVSFKNLKTGKTDHVKTRFVFIGAGGAAVKLLQLTGLPEAKQYAGFPVGGEFLITDNPAITAQHTAKVYGRAELGAPPMSVPHIDTRYIDGKKYVLFGPFATYSNKFLKNGSQLDLLASTNKSNVLLMTTVGLENLDLVKYLVSQVMMSDEDRLNELRKYYPDAKAEDWRLSQGGQRVQIIKKEPGKPATLQFGTEIFASKDGAVTALLGASPGASTSPYIMLNLLEKAFPQQTEGKWNQKLHEIVVSYKQDLSKDPVLLDKVRQYTSSTLGLNYTSPFKAANDETAAAPVAKAN
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: QKI_RAT
Sequence: MVGEMETKENPNPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN
What is the function of this protein?
RNA-binding protein that plays a central role in myelinization.  Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence.  Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation.  Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation.  Participates in mRNA transport by regulating the nuclear export of MBP mRNA.  Also involved in regulation of mRNA splicing of MAG pre-mRNA.  Acts as a translational repressor (By similarity).
What are the official names of this protein?
KH domain-containing RNA-binding protein QKI, Protein quaking, RqkI.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: STE7_CANAL
Sequence: MTRTTRIDTQEATKHKDLPPVPSPLSLSSNPNPECLMESKSLGRKNFKKLSLDASPVKSTSGSLRSSDMMSIKEPTSLRQKRQRPPPILHLPTASSSATSTPTSNITGSSSASSIQFAQKSPGSGVIVSQTLSRPSSAGGIPSSGYSSLNVNQSNRNVDPDNVVSTDMILNQISNLDLTSMNHHRQHYQNSHHHLPTTNRKRQTVISSISPTKSSAASSSLEPQIQSLPASSQSPIATTSSLKLNNKDLLTLKQLGSGNSGSVSKILHIPTQKTMAKKIIHIDSKSVIQTQIIRELRILHECHSPYIIEFYGACLNNNNTIVICMEYCNCGSLDKILPLCENKQFPTFVLKKLSFAILSGLTYLYTTHKIIHRDIKPNNVLMTHKGEFKLCDFGVSRELTNSLAMADTFVGTSMYMSPERIQGLDYGVKSDVWSTGLMLIELASGVPVWSEDDNNNDDDEDDEDDAYVRQGSIAAERNGQNSPSRSRKNKQKGNGYNSYNGPEGILDLLQRIVNEDAPTLTNKINPVTKLPYDKYLCQFIDLCLIKDDSVRKTPWQLLEDKEHFFKGVEEGVYDKEHKSWAKKIRKCKV
What are the official names of this protein?
Serine/threonine-protein kinase STE7 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Protein: TTCA_CERS5
Sequence: MTDELDDIHPILQGAPQTTEFRKLRKRIVRNVREALDQYGMVDGRDARWLVCLSGGKDSFTLLAALIELKWRGLLPVELLACNLDQGQPGFPATVLPEFLARMGIPHRIEYQDTYSIVVDKIPQGRTYCSLCSRLRRGNLYRIAREEGCSAIVLGHHRDDILETFFMNLFHGGRLATMPPKLVNEEGDLFVYRPLAFVAEADCERFARSMNYPIIPCDLCGSQDGLQRQQVKQILDGWEARSPGRRQVMFRALMNARPSHLLDPGLFDFAGLATGTASGRNGAEPPQLRGGD
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_GEOUR
Sequence: MRTDTDKLIIAGREFNSRLMVGTGKYADFQQMVKAIEVSGAEIITVAVRRVNISDRNKESLLDHIDTKKYTLLPNTAGCYTADDAIRTCRLAREAGLSDFVKLEVLGDEKTLFPDNEELLKAAKVLIKEGFTVLPYTTDDPIVCKKLEDIGCAAVMPLGAPIGSGLGIRNPYNIRIILDTVKVPVIVDAGVGTASDAAIAMELGCHGVLMNTGIAGAKDPIAMAEAMNLAVRAGRLAYRAGRIPKKLYATASSPVEGTIE
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNP25_RAT
Sequence: MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
What is the function of this protein?
t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8243676, PubMed:8103915).  May play an important role in the synaptic function of specific neuronal systems.  Associates with proteins involved in vesicle docking and membrane fusion.  Regulates plasma membrane recycling through its interaction with CENPF.  Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (PubMed:12403834).
What are the official names of this protein?
Synaptosomal-associated protein 25, SNAP-25, Super protein, SUP, Synaptosomal-associated 25 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the SNAP-25 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell membrane; Lipid- anchor. Synapse, synaptosome. Photoreceptor inner segment. Note=Membrane association requires palmitoylation (By similarity). Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity). Colocalizes with KCNB1 at the cell membrane (PubMed:12403834). Colocalizes with PLCL1 at the cell membrane (PubMed:23341457).
Protein: PYRF_NEIM0
Sequence: MNPLISDFQTPQQRTPVIVALDFANEKDTLGFVRNLDPTLCQIKIGKELFTATGRSLAESLINQGFKLFLDLKYHDIPHTVAQACKVAADMGVWMVDMHASGGRRMMEAAAEAVAGYGTKPLLIGVTVLTSMEQSDLAEIGLNIAPEEQVIRLAKLAQSSGLDGVVCSAQEAAPLRRELGQDFVLVTPGIRLDVAGNNDDQRRIMTPAEALAAGSTYLVMGRPVTQAANPLAVLREVNRVANLEAN
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: TRMFO_SYNPW
Sequence: MIGAGLAGTEAAWQVAEAGLDVQLVEMRPIRRSPAHHSSECAELVCSNSFGALSSDRAAGLLQEELRRLGSVVIQMADRHAVPAGGALAVDRGRYSASLTQLLEQHPRVSFVREEQIALPATDQVTVLATGPLTSDALAEDLRRFTGRADCHFFDAASPIVEGDSVDMTQAFRASRYDKGDADYINCPMNREQYLGFRDALLAAEQAELKDFDQGNATFFEGCLPIEELARRGEDTMRYGPLKPIGLWDPRWGDVNDRDVRRAKRAYAVVQLRQEDKDGRLWNLVGFQTNLKWGEQKRVLQMIPGLEGAEFVRFGVMHRNTFLEAPALLDATLQFRSRPNLLAAGQITGTEGYAAAVAGGWLAGTNAARLVRGERPIDLPRTTMVGALTHFISEAPSGKFQPMPPNFGLLPELPERIRDKRARYGAYRDRALADLLLAREEQALGNVPCPA
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.