PharMolix/UniProtQA huggingface dataset:
Protein: ARP4_EMENI
Sequence: MNASVPPSAAEYGGDEVSAIVLDPGFSTTRAGFAGEDTPKSLVPTYYGKYSFEGQEKLIFGDDVFVTPRPSLSVGNPMGRDGVVEDWDMAEKLWEYSFTSRLTGAKPSNPLHNGLNDLVEGELPTEMEGVETNEKPLADSPLLMSECSWNPTKAREKTIEIAMEKWGTPAFYLARNGVLASFAAGKASALVVDIGASNISVTPVHDGMVLKRGVQHSPLGGDYISSQIRALFKTNTPQPITITPHYLISSKTAVEAGQPPQAKYKTFPPEKAPDASYRSLLEERTLTEFKECVVQVWPGPTKLSAPGPNGVPNEEMARSTPGRPFEFPDGYNQVFGVDRYRVVESLFDAKATILDPDSQFPAPTPAQTIPELIKAALNGVDVDLRPHLLANVVVTGASSLLYGFTDRLNQELMQLYPGPRVRISAPGNTSERRFSSWIGGSILASLGTFHQMWISKKEFDEHGPNIVEKRCK
What is the function of this protein?
Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair.  Is required for NuA4 complex integrity.  Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
What are the official names of this protein?
Actin-related protein 4, Actin-like protein arp4, Actin-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNLJ_FRAAA
Sequence: MNAPPGSGDAAASALEAASQAEASEVEASEAEAASAVEAASAVGAGGAVQPAVAASVADRARAAELARELDEHAYRYYVLDSPTVSDAEYDRLMRELTALEEHHPELRTPDSPTQKVAGSYSTLFTPVEHLERLLSLDNVFDDDEFHLWAARAARETEVDGWLCELKIDGLAVDLVYEEGRLVRAATRGDGRTGEDITPNIRTLASVPTRLRGASVPELLEVRGEVFFPTEKFAELNASLVAGGGKPFANPRNAAAGSLRQKDPRVTATRPLDMIVHGLGAQRGFDAASQSAAYARFAEFGLPVSTHFEVLASVGDVLAFIHRWGRARHDVEHEIDGVVVKVDAFALQRRLGSTSKAPRWAVAFKYPPEEVTTKLRDIRVNVGRTGRVTPFGELEPVLVAGSTVGLATLHNVDEVGRKGVLIGDTVVLRKAGDVIPEIVGPVVDLRDGTERAFVMPTHCPECGTELVRPEGEVDIRCPNTDACPAQLRELIFHLASRNALDIDGLGYETAIALLEADRVGDIGDIFHLTPESFEGLRGFGQKKIDQILRGVEAARHRPLWRLLVGLSIRHVGPTAARALARELRSLDAIAAAPAEQLAAVEGVGPKIASAVVDWFADARHRDIVARIAAGGASLADAGAAEGPRPLDGVAVVITGTLDGWSRDSATEAVQGRGGKVTGSVSKKTAFVVVGADPGAAKYDKARSLGVPVLDEAGFAVLLERGADAARERAVAADAPAAPAAPDTSGGQGAPDVDSARRAQRAQRAQDDAPPG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: HIS4_BURMS
Sequence: MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILGEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACSAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLARKFEDYGVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNIVDIEKLCEVEDEGIEGVICGRAIYSGDLDFAAAQKRADELNGELDDA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM05_OENBE
Sequence: MFPLNFHYEDVLRQDLLLKLNLANVMEVPGLCEIRIVPKTSSTYDFIIKNGKLAMEILRGQKFIQTERGSTGKSFRSNPFLESNKDKGYVSDLARQSILRGHGMSNFLVRILTVMSLLDSRVEIRENSIQFSMETEFCEFSPELEDHFEIFEHIRRFNVTIVTSANTQDETLLLWSGFLQKDEGESFKWKTP
What are the official names of this protein?
60S ribosomal protein L5, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: URE1_BURO0
Sequence: MTLRLSRRAYAEMFGPTTGDRVRLADTELLIEIERDFTTYGEEVKFGGGKVIRDGMGQSQRVAADVPDTVITNAVILDHWGIVKADIAIKHGRIAAIGKAGNPDIQPGVTIAIGAATEVIAGEGLIVTAGGIDTHIHFISPQQIDEALASGVTTMLGGGTGPATGTNATTCTPGPWHMERMLQAADGWPINLGFLGKGNASLPQPLVEQIAAGAIGLKLHEDWGTTPAAIDNCLSVADDTDTQVAIHTDTLNEAGFVESTVAAFKGRTIHTYHTEGAGGGHAPDILKVCGEMNVLPSSTNPTRPYTINTLDEHLDMLMVCHHLDPSIAEDLAFAESRIRRETIAAEDILHDLGALSMLSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALPEDTARNDNFRAKRYVAKYTINPALTHGIAHEVGSIEPGKWADLVLWEPAFFGIKPSMILKGGMIAVAQMGDPNASIPTPQPVHYREMFATRGGALARTSLTFVSQMAADAGIAERYGLAKRIVPVRNCRNVTKADMIHNAWRPSISVDPETYDVIADGQLLTCEPATVLPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
Protein: CRCB_THIDA
Sequence: MTAFLAVGFGAAVGAWLRWGLGLWLNPAYPAMPLGTLAANVIGGYFIGLVLAWFAEHPGVPPEARLFVITGLLGGLTTFSTFSAEVVTALTRGLWLTGSLIAFAHLAGSFIATGLGFYSLKFLK
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y452_LISIN
Sequence: MTIKNKVIIITGASSGIGEATAILLAEKGAKLVLAARRVEKLEKIVQTIKASSGEAIFAKTDVTKREDNKKLVELAIERYGKVDAIFLNAGIMPNSPLSALKEDEWEQMIDINIKGVLNGIAAVLPSFIAQKSGHIIATSSVAGLKAYPGGAVYGATKWAVRDLMEVLRMESAQEGTNIRTATIYPAAINTELLETITDKETEQGMTNLYKQYGVTPDRIASIVAYAIDQPEDINVNEFTVGPTTQPW
What are the official names of this protein?
Uncharacterized oxidoreductase Lin0452.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: TSAD_STAA1
Sequence: MTKDILILAVETSCDETSVSVIKNGRDILSNTVLSQIESHKRFGGVVPEVASRHHVEGITTTINEALVDADVSMEDIDAIAVTEGPGLIGALLIGVNAAKALAFAYDKPLIPVHHIAGHIYANHIEEPLTFPLIALIVSGGHTELVYMKDHLSFEVIGETRDDAVGEAYDKVARTIGLNYPGGPQVDRLAAEGEDTYSFPRVWLDKDSYDFSFSGLKSAVINQLHNQRQKNIPIIEANVATSFQNSVVEVLTFKAIQACKEYSVQRLIVAGGVASNKGLRQSLADQCKVNDIQLTIPSPKLCTDNAAMIGVAGHSLYQQGRFADLALNGHSNIDLEEYSAE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_HYPNA
Sequence: MTPFPPPLSGSAQDETPELRPRFDENGLIAAIAQDAGTGEVLMLAWMNAEALQKTIETGRATYWSRSRGALWVKGETSGHTQEVIELRVDCDQDAVLLKVRQTGGACHTHRESCFYRRIEGGVLSFTGKAD
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM34_AJECG
Sequence: MAFNFNWSPLMADAGFYTRAQELLTAALNKSPKPPIIVDDIVVTELNLGSNPPELEILEIGDLAEDRFRGIFKMSYAGDAFLTLKTCVQANPLNTYLLTRHPFASPQPLAAATGLTIPLQITLSDIKLSGFVILVFSKQKGITVVFRNDPLESLKVSSTFDSIPFVRDYLQKEIEGQLRILFMDELPAIIHRLSLRLWGTEYSELETTSAQVTNPPLEGPGLDPLLNPPEDPVDASGNVLSTSEIASLSLDSGVEMHSLFSRKNVLRLAALTDSQRTLSLFTPSIQEVVFRAWTGLMEQADGPSGLVSPMSPPLSRTHSHVATSSLSLQDAASLASSSHSRLSLPSTGFSGYGLSMGAGRHSKAHARKRKKRVVDLRRRPKNTDDMESVSGESEFTESTSAASVFSGSTIPEENNDDPVTPPGSPPRTIRQPTLCDRIVARNGAERNARRGIPAEFGHDIPASRTTLPTANDIARMLATTSSLQQQLHPANSKSLPPQVPPQEPALRPSLTSNSPYPIEKPNASNYTSSGDSQQQQQQQQQHQTHLPSSLIMEAAQSGGILEQAWMMKMASEIARRIQDEKMGGEDAAGSSNNKNDNKNNNTGGFWEQSLMRSHTPPPAYRH
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: NUOH_SALCH
Sequence: MSWITPDLIEILLSILKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLSFAIVPVSPNWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTVSYEVFLGLSLMGVVAQAGSFNMTDIVNNQAHLWNVIPQFFGFVTFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTVSALMVTLFFGGWHGPFLPPFVWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKVCLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FUR2_MYCFO
Sequence: MSTTADFQQMLRXADLRVTRPRVAVLHAVHXXTRDADTETIIRSVREDLPEVSHQAVYDSLHALTAAALVRRIQPSGSVVSRYESRIGDNHHHVVCRSCGAIADVDCSXAGSAPCLTASEDHGFEIDEAEVIYWGTCPECSVAPSR
What is the function of this protein?
Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
What are the official names of this protein?
Ferric uptake regulation protein 2, Ferric uptake regulator 2.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF2_PROMS
Sequence: MLAFNFFGATEGGLFDINATLPLMAIQVVALTYILNSLFFKPVGNVVEKREKFVSNNIIEAKNKLSEVKKLEADLLTQLQSARTEAQRIVSEAENESDKLYKEALELANNEANASKEKARLEIESQTSAARDQLSKQADDLSELIVNRLILEK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
What are the official names of this protein?
ATP synthase subunit b', ATP synthase F(0) sector subunit b', ATPase subunit II, F-type ATPase subunit b', F-ATPase subunit b'.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: AGC15_ARATH
Sequence: MDLASKKNTANVGSKEIDPIKPKSPRSSLSPFSLKLGDNVPRNPHFDPKKMDPLVKHQPPKSLEPPPSTRGTNSEGDLKHNTYSSDGDSLAMRKNAPKNLHYDPKKIVPLTTSETYSPSARNHHHHRTKSPDKKRAPRHNGDYAYGDNLVGPSAQPFKPHTGGDVRWDAINSIASKGPQIGLDNFRLLKRLGYGDIGSVYLADLRGTNAVFAMKVMDKASLASRNKLLRAQTEREILSLLDHPFLPTLYSYFETDKFYCLVMEFCSGGNLHSLRQKQPSRRFTEEAARFYASEVLLALEYLHMLGVVYRDLKPENILVRDEGHIMLSDFDLSLRCTFNPTLVKSSSVCSGGGAILNEEFAVNGCMHPSAFLPRLLPSKKTRKAKSDSGLGGLSMPELMAEPTDVRSMSFVGTHEYLAPEIIRGEGHGSAVDWWTFGIFLYELLHGTTPFKGQGNRATLHNVVGQPLKFPDTPHVSSAARDLIRGLLVKDPHRRIAYTRGATEIKQHPFFEGVNWALVRSAAPPHIPDPVDLGPYAAARGKTKSHGGGDHCNSMKPEPLVACAAGPTDDTAYIDFEYF
What is the function of this protein?
Functions redudantly with AGC1-7 as signaling component in the pollen tube.  Required for polarized growth of pollen tubes.
What are the official names of this protein?
Serine/threonine-protein kinase AGC1-5, AGC serine/threonine-protein kinase subfamily 1 member 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Protein: GON1_DICLA
Sequence: MAAQTFALRLLLVGTLLGTLLGQGCCQHWSYGLSPGGKRELDGLSETLGNQIVGSFPHVATPCRVLGCAEESPFPKIYRMKGFLDAVTDRENGNRTYKK
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-1, Progonadoliberin I.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: RDC3_METCM
Sequence: MAPSQDLGERDQQQPPAPYPADLENGRYGRIPNGHGSTTGTEGSGTLQLNEKDDATLRPNGSHDVKEEGQETSTNVVDWDGPDDPANPQNWTLSKKWLNISVVGLITFNVPLASSMFAPAVPQLLQDFHTDNASLSTFVVSVYILGLAAGPLILAPMSELYGRLNVYHVGNVLFIIFTVACGLATNINMLVAFRFLAGLVGAAPIAIGAGTIADVTNLQQRGTAMSIWSLGPLLGPSIGPVIGGFLAQAAGWRWIFWLLAIIAGAVAIISFFVLQETHAPTLLKRKTNRLRKETGNMALRSKLDTQLPPKEMFLRAIVRPCKMLLFSPVCLILSFYSAFVYALIYFMFSTFSFIFKASYGFNQGTVGLVYLACGIGMLLGLGIQQLTGDRIRQRLADKRNGGDHKPEYRFPPMFMAGGLLPAGLFMYGWAVQHHVQWAVPLLGTLIAGIGICIISICINTYLVDTFTMYAASALAASAVLRSVFAAVLPLFALQMYNKLGLGWGNSLLAFVGLGMWPITFLFFVHGEKLRKNPKFQIKF
What is the function of this protein?
Efflux pump that might be required for efficient secretion of radicicol or other secondary metabolies produced by the radicicol gene cluster (PubMed:18567690).
What are the official names of this protein?
Efflux pump rdc3, Hypothemycin biosynthesis cluster protein rdc3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GPTC2_HUMAN
Sequence: MFGAAGRQPIGAPAAGNSWHFSRTMEELVHDLVSALEESSEQARGGFAETGDHSRSISCPLKRQARKRRGRKRRSYNVHHPWETGHCLSEGSDSSLEEPSKDYRENHNNNKKDHSDSDDQMLVAKRRPSSNLNNNVRGKRPLWHESDFAVDNVGNRTLRRRRKVKRMAVDLPQDISNKRTMTQPPEGCRDQDMDSDRAYQYQEFTKNKVKKRKLKIIRQGPKIQDEGVVLESEETNQTNKDKMECEEQKVSDELMSESDSSSLSSTDAGLFTNDEGRQGDDEQSDWFYEKESGGACGITGVVPWWEKEDPTELDKNVPDPVFESILTGSFPLMSHPSRRGFQARLSRLHGMSSKNIKKSGGTPTSMVPIPGPVGNKRMVHFSPDSHHHDHWFSPGARTEHDQHQLLRDNRAERGHKKNCSVRTASRQTSMHLGSLCTGDIKRRRKAAPLPGPTTAGFVGENAQPILENNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGLGFPLPKSTSATTTPNAGKSA
What is the function of this protein?
Enhances the ATPase activity of DHX15 in vitro.
What are the official names of this protein?
G patch domain-containing protein 2.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleolus.
Protein: HRCA_XANAC
Sequence: MRASQSPMLDPRARQLLRTLIARYIRDGEPVGSKTLAQHAGLDVSPATIRNILADLEDVGLLSSPHTSAGRVPTAHGYRVFVDSLVQMQPPGEEEVRRLRAELASGNGTQSLLGSASQMLSAMSHFVGVVSAPRREQFAFRHIDFVALDARRVLAILVFADNEVQNRVIEPRRAYEPAELERVANYLNAQFAGRALADIRACLLRELRMAKSEMEQLLAHSVELASEALVPADADDMVMAGQTRLMGVQDLSDLDRLRELFEAFASKREILQLLERTIQAPGVRIFIGEETGMVSLEDVSLVTAPYAANGQVLGVLGVIGPKRMAYDRLIPLVQTAADVLGAAMQSPGAR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: GPDA_BACC7
Sequence: MTKITVVGAGSWGTALAMVLADNGHDVRIWGNRSELMDEINTKHENSRYLPGITLPSTIVAYSSLEEALVDVNVVLLVVPTKAYREVLQDMKKYVAGPTTWIHASKGIEPGTSKRISEVIEEEIPEDLIKDVVVLSGPSHAEEVGLRQATTVTSAAKRMEAAEEVQDLFMNSYFRVYTNPDIVGVELGGALKNIIALAAGITDGLGLGDNAKAALMTRGLTEIARLGRKMGGNPLTFAGLTGMGDLIVTCTSVHSRNWRAGNLLGKGHSLEEVLESMGMVVEGVRTTKAAHELAEKMEVEMPITAALYDVLFNGNNVKDAVGSLMGRVRKHEVEAIPDLL
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EI3D1_DROPS
Sequence: MSETINTAAQFPSFEKPTVQFNERGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTSTSNNDKKYQNKYASSFGTGNQYSYYHEEDETTFHLVDTARVQKPPHQRGRFRNMRGRGGRGRNPRGGLNNHHHHGMTTLNGKNVKARDTRRGMGKKFGHRGPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPNIKDGVDIATCGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTVGNVFATDAILATIMCSTRSNYSWDIVIEKVGDKIFMDKRDHTEFDLLTVNESSVEPPTDDDSSCNSPRNLAIEATFINHNFSQQVLKTGDQEAKFKFEEPNPFISEDEDIQVASVGYRYKKWELGSDIVLVARCEHDGVLQTPSGEPQFMSIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNACKLAKWTVQAVLAGSDQLKLGYVSRINPRDHSRHVILGTQQFKPHEFATQINLSMDNAWGVLRCIIDLVMKQKDGKYLIMKDPNKPIIRLYDIPDNTFDSDDSDDGEGDDGEGFQQVYNYANNSNKI
What is the function of this protein?
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit D-1, eIF3d-1, Eukaryotic translation initiation factor 3 subunit 7-1, Eukaryotic translation initiation factor 3 subunit p66.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLT13_MOUSE
Sequence: MRRFVYCKVVLATSLMWVLVDVFLLLYFSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKTLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLDVSRLSGPVIMLKCHHMRGNQLWEYDAERLTLRHANSNQCLDEPSEEDKMVPTMQDCSGSRSQQWLLRNMTLGT
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:8618846, PubMed:27629416).  Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (PubMed:12407114).  Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system (PubMed:12407114, PubMed:27629416).  Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar.  Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC.  Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain (By similarity).  May promote neurogenesis through glycosylation and stabilization of PDPN (PubMed:27629416).
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase 13, Polypeptide GalNAc transferase 13, GalNAc-T13, pp-GaNTase 13, Protein-UDP acetylgalactosaminyltransferase 13, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: CO8A1_HUMAN
Sequence: MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM
What is the function of this protein?
Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.
What are the official names of this protein?
Collagen alpha-1(VIII) chain, Endothelial collagen.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: HNF4A_XENLA
Sequence: MRLSKALIDMDMADYTEALDPAYTTLEFENMQVLSIGTDTSTSDVTSLSASNSIGINSLCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINVLIQAEVLSQQITSSVGVLNTDIRGKKIACIIDVCDSMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMFKDILLLGNDRLIPRNCPELEVGRVAVRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPTKIKRMRYQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMAKIDNLLQEMLLGGSANEASHTHHHLHPHLVQDHLATNVIVANNTLPSQLHNGQMSTPETPQPSPPAGSGAEQYKIVHGTIASINKQPTSIPQSTITKQEAM
What is the function of this protein?
Transcriptional regulator; binds and activates the promoter for the HNF1-alpha gene (PubMed:8808405).  Potential initiator of a transcriptional cascade within a subset of cells committed to a specific developmental program (PubMed:8808405).  Could be a determinant for asymmetry in early development (PubMed:8808405).  May play a role in the regulation of the circadian clock (By similarity).
What are the official names of this protein?
Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMN_LISMO
Sequence: MEKSSIYGLTWTNLTEWLEAHGQKKFRATQVWDWLYRKRVKTFEEMSNVPKETIELLTANFVMNTLEEQVVQESTDGTTKYLFKLSDGNLIETVMMKQEYGLSVCVTTQVGCNIGCTFCASGLLKKSRDLTAGEIVEQIMNVQHYLDGRNLEERVSHVVVMGIGEPFDNYDNVMDFLRVINHDKGLAIGARHITVSTSGLAPRIIDFANEDFQVNLAISLHAPNNELRTSIMRINKTYSIEKLMEAIHYYVNKTNRRITFEYIMLKGVNDHKKEALELAALLGEHRHLAYVNLIPYNPVDEHIDYERSTKEDVLAFYDTLKKNGINCVIRREHGTDIDAACGQLRSKQIKRVGVRERMKQKQAAAEE
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.