PharMolix/UniProtQA huggingface dataset:
Protein: ACCA_CAUVN
Sequence: MAAHYLDFERPIADLESKIEELSRLSETAGPGAFDTEIQALRDRAQELRKEAYANLDAWQKTMVARHPQRPHLRDYVAGLIDEFVELRGDRKFADDQAIVGGLGRFRGQPVVVMGHEKGHDTTTRLKHNFGMARPEGYRKAVRLMDMAERFNLPVITFVDTAGAYPGLGAEERGQAEAIARSTERCLTLGVPMVATIVGEGGSGGAIALAGANRVLILEHSIYSVISPEGAASILWRDGARAKDAATQMRITAQDLIKLGIVDRIVEEPAGGAHSDTEAAIQAVGDAVEDELKAMAAMSPAELKKQRSDRFYAIGRAGLQ
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSN17_BOVIN
Sequence: MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWSEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFVGIALLQIFGICLAQNLVSDIKAVKANW
What is the function of this protein?
Regulates ADAM10 maturation.
What are the official names of this protein?
Tetraspanin-17, Tspan-17.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LY6K_MOUSE
Sequence: MAFLVALLVVLGLQLVQSNALTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEPKEFLIEKPMPFLFYKCCQWDSCNGEGPPTDQLLKEQPGKASGRRHRYIELLLTGFMVLTANGLSALCLL
What is the function of this protein?
Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (PubMed:24501175).  May play a role in cell growth (By similarity).
What are the official names of this protein?
Lymphocyte antigen 6K, Ly-6K.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cell membrane; Lipid-anchor, GPI-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Membrane raft.
Protein: RPOC_KLEP7
Sequence: MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELACPTAHIWFLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERNQILTEEQYLDALEEFGDEFDAKMGAEAIQALLRNMDLEQECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDSVNAKGEGMVLTGPKEAERIYRAGLASLHARVKVRITEYEKDDNGEFVAKTSLKDTTVGRAILWMIVPKGLPFSIVNQALGKKAISKMLNTCYRILGLKPTVIFADQTMYTGFAYAARSGASVGIDDMVIPEKKYEIISEAEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEQQVSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTLEGITMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHEHWCDLLEANSVDSVKVRSVVSCDTDFGVCAHCYGRDLARGHLINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSIKLSNAKSVVNSSGKLVITSRNTELKLIDEFGRTKESYKVPYGAVMAKGDGEQVAGGETVANWDPHTMPVITEVSGFIRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKIVDAQGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQESGGTKDITGGLPRVADLFEARRPKEPAILAEISGIISFGKETKGKRRLVITPVDGSEPYEEMIPKWRQLNVFEGERVERGDVVSDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIESAGSSDFLEGEQVEYSRVKIANRELEANGKVGATFSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAGELPAAPQVSVEEASANLAELLNAGLGGSDND
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: OBG_VIBVY
Sequence: MKFVDEAVIKVQAGDGGNGVVSFWREKFVTKGGPDGGDGGDGGDVYIQADENLNTLIDYRFQRFYEAERGQNGSGGNCTGKRGKDITLRVPVGTRAVDIHTNEIVAEVAEHGKKVMVAKGGWHGLGNTRFKSSVNRAPRQKTMGTKGEIRELRLELLLLADVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRVLLHMIDIFPIDQSDPVQNALTIIDELEQYSEKLANKPRWLVFNKVDLVSEEQADEIIQEVIDALGWEEQYFKISAVNRQGTKELCYKLADFMEQLPREEQEVSEEEKVNFMWDYHPDANQGEVITEDDDDWDDWDDEEDDGHVIYVRE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_RHOPT
Sequence: MAKDATRIRRRERKNIASGIAHVNSSFNNTTITITDAQGNAIAWSSAGTMGFKGSRKSTPYAAQVAAEDVAKKAQEHGMRTLEVEVAGPGSGRESALRALQAAGFTVTSIRDVTTIPHNGCRPRKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: PAPA5_MYCTO
Sequence: MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME
What is the function of this protein?
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis.  Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
What are the official names of this protein?
Phthiocerol/phthiodiolone dimycocerosyl transferase, Acyltransferase PapA5, Phthiocerol/phthiodiolone O-acyltransferase, Polyketide synthase-associated protein A5.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase PapA5 family.
Protein: CK5P1_HUMAN
Sequence: MHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRDSSAYC
What is the function of this protein?
Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754).  Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754).  Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646).  Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458).
What are the official names of this protein?
Mitochondrial tRNA methylthiotransferase CDK5RAP1, CDK5 activator-binding protein C42, CDK5 regulatory subunit-associated protein 1, mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase, mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: BL1S4_YEAS8
Sequence: MQDNSSHSRESASAGDDPLGIDKLTVDYDYLLYKIRDYVQSIQLDTTELCKKQNEVMVNGIIENTIDKNIAKFKELLEKCDTLENHYEMLNQLAIITDTFKERIAEAVNNYNSLKKGASKSK
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit CNL1, BLOC-1 subunit CNL1, CNO-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Punctate pattern.
Protein: Y1764_CENSY
Sequence: MSYTDPDDSLPEHVPGEAEMSAQKEAILKQILEPQARMRLSNIRMVKPETAAALESHLINAASQGRLAGKISDEHLKQILQSMQKPRREFKINRR
What are the official names of this protein?
DNA-binding protein CENSYa_1764.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: RRP41_METKA
Sequence: MEERPERLISEDGLRLDGRKPDEMRPLKIQAGVLKRADGSAYLELGANKIVAAVYGPRELHPRHKQKPDRAVVRFRYNMAPFSVDERKRPGPDRRSIEISKLSKEALEPAIFTEYYPRTAIDIFVEVLQADAGTRCAGISAASVALADAGIEMRDLVAACAAGKVEGKVVLDPMYYEDGYGEADVPLAMMPKEGKITLLQMDGDMTPGEFKQAVKLAKKGCKIVYKEQRRALKEKYGGD
What is the function of this protein?
Catalytic component of the exosome, which is a complex involved in RNA degradation.  Has 3'->5' exoribonuclease activity.  Can also synthesize heteromeric RNA-tails.
What are the official names of this protein?
Exosome complex component Rrp41.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp41 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOLD_BACAA
Sequence: MQTVRMTTAQALVKFLNQQYVEFDGKQQKFVKGIFTIFGHGNVVGLGQALEEDAGELEVYQGRNEQGMANAAMAFAKQKHRKQIMACTSSVGPGSANMITSAATASANNIPVLLLPGDVFATRQPDPVLQQIEQTHDLSISTNDAFRAVSKYWDRINRPEQLMTAMIQAMRVLTNPADTGAVTICLPQDVQGEAWDFPSYFFQKRVHRIERRLPTKASLADAVEMIKRKKKPVMICGGGVRYAEAAEELKQFAETFHIPFGETQAGKSAIESSHPYNLGGIGVTGNVAANTIAKEADLVIGIGTRFTDFTTASKQLFQNEEVEFLNINISEFHANKLDALKVIADAKEALLALIDELQEIDYQSSYTVEIADAKDAWETELSRLHNIRFTCQDFTPEVEGHFNENLNEYVDALGTQLTQTAVIGQINTLLDKDAIIVGAAGSLPGDLQRMWASRKPNTYHMEYGYSCMGYEVAGALGAKLAEPSKEVYAMVGDGSYQMLHSELVTSLQENKKINVLLFDNSGFGCINNLQMGNGMGSFGTEFRYRNQETRKLDGAIMKIDFAASAAGYGVKTYHVTSLEQLQEALIDAKKQTVSTLIDIKVLPKTMTNGYESWWHVGVAEVSKNQSVQAAYESKVSNLQQARSY
What is the function of this protein?
Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG).
What are the official names of this protein?
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase, THcHDO hydrolase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: RL7_BORBR
Sequence: MALSKAEILDAIAGMSVLELSELIKEMEEKFGVSAAAAAVAVAAPAAGGAGAAAAEEQTEFTVVLLEAGANKVSVIKAVRELTGLGLKEAKDLVDGAPKPVKEALPKADAEAAKKKLEEAGAKVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: DEOD2_PHOPR
Sequence: MATPHINAELGDFAETVLMPGDPLRAKFIAENFLEDVKQVCDVRSMLGFTGTYKGKRVSVMGHGMGIPSCSIYVHELIKDFGVKNIIRVGSCGAVHDDVKLMDIIIGMGASTDSKVNRIRFNDHDFAAIADFHLLETSVQQARLQNVNVRVGNIFSADLFYSPEEGLFDKMEKLGMLGIDMEAAGIYGVAAELGAKALTILTVSDHIKRGEKLSSEDRQKSFGEMMNVALETAVNI
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type 2, PNP 2.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: RS2_NEIMA
Sequence: MSQITMRQMIEAGVHFGHQTRFWNPKMAQYIFGARNKIHIVNLEKTLPMFQDAQEAVRRLVANKGTVLFVGTKRQARDIIREEATRAGMPFVDYRWLGGMLTNYKTVKQSIKRLEEKTAALENAAESGFSKKEILEMQRDVEKLERSLGGIKNMKGLPDAIFVIDTGYQKGTLVEAEKLGIPVIAVVDTNNSPDGVKYVIPGNDDSAKAIRLYCRGIADAVLEGKNQALQETVAAAQEAAAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SEP3_ARATH
Sequence: MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSSSSMLRTLERYQKCNYGAPEPNVPSREALAVELSSQQEYLKLKERYDALQRTQRNLLGEDLGPLSTKELESLERQLDSSLKQIRALRTQFMLDQLNDLQSKERMLTETNKTLRLRLADGYQMPLQLNPNQEEVDHYGRHHHQQQQHSQAFFQPLECEPILQIGYQGQQDGMGAGPSVNNYMLGWLPYDTNSI
What is the function of this protein?
Probable transcription factor active in inflorescence development and floral organogenesis.  Functions with SEPALLATA1/AGL2 and SEPALLATA2/AGL4 to ensure proper development of petals, stamens and carpels and to prevent the indeterminate growth of the flower meristem.  Interacts with APETALA1, AGAMOUS or APETALA3/PISTILLATA to form complexes, that could be involved in genes regulation during floral meristem development (PubMed:10821278, PubMed:11206550).  Binds specifically to the CArG box DNA sequence 5'-CC (A/T)6 GG-3' (PubMed:16080001).
What are the official names of this protein?
Developmental protein SEPALLATA 3, Agamous-like MADS-box protein AGL9.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIAA_RHORT
Sequence: MIDPLASPGSAPLIVIAGPTASGKSALALRVARRFNGVVINADSMQVYRDLRILSARPSVEDEAAAPHALYGVLDGAEVCSVGRWLALADGAVAAARAAGRLPILCGGTGLYLKAALEGLASVPEVAPEVRAEARELLAALGPAALHAKLAELDRAMAERLRPSDAQRIARAYEVVRGTGRSLMDWWSDPVATPALPGRPLLLVIDPPRAAQRAACDARLLAMVAAGALDELALLLARRLDPALPVMRAVGVPELARTLRGEVGLAEAVERAQGATRRYAKRQGTWIRTQLRPDRVLSESLVTQLSESQLTDIDNFLYAFLLTGAS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: SP140_HUMAN
Sequence: MAQQGQQGQMASGDSNLNFRMVAEIQNVEGQNLQEQVCPEPIFRFFRENKVEIASAITRPFPFLMGLRDRSFISEQMYEHFQEAFRNLVPVTRVMYCVLSELEKTFGWSHLEALFSRINLMAYPDLNEIYRSFQNVCYEHSPLQMNNVNDLEDRPRLLPYGKQENSNACHEMDDIAVPQEALSSSPRCEPGFSSESCEQLALPKAGGGDAEDAPSLLPGGGVSCKLAIQIDEGESEEMPKLLPYDTEVLESNGMIDAARTYSTAPGEKQGEEEGRNSPRKRNQDKEKYQESPEGRDKETFDLKTPQVTNEGEPEKGLCLLPGEGEEGSDDCSEMCDGEEPQEASSSLARCGSVSCLSAETFDLKTPQVTNEGEPEKELSLLPGEGEEGSDDCSEMCDGEERQEASSSLARRGSVSSELENHPMNEEGESEELASSLLYDNVPGAEQSAYENEKCSCVMCFSEEVPGSPEARTESDQACGTMDTVDIANNSTLGKPKRKRRKKRGHGWSRMRMRRQENSQQNDNSKADGQVVSSEKKANVNLKDLSKIRGRKRGKPGTRFTQSDRAAQKRVRSRASRKHKDETVDFKAPLLPVTCGGVKGILHKKKLQQGILVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSVRCGGWPLRWLMENGFLPDPPRIRYRKKKRILKSQNNSSVDPCMRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTPWNCIFCRMKESPGSQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGFRLEAEFEKNFKEVFAIQETNGNN
What is the function of this protein?
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577).  May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577).  May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).
What are the official names of this protein?
Nuclear body protein SP140, Lymphoid-restricted homolog of Sp100, LYSp100, Nuclear autoantigen Sp-140, Speckled 140 kDa.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Cytoplasm. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863). Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577).
Protein: PROA_CHLPM
Sequence: MSMNLKETIILKLDEVRTASRTLVTLTDSTINEVLLDLAGRIAPNAAAILEANRSDLERMERSSPMYDRLLLNEKRLEGIAADIRNVASLPSPLDMTLEERTLENGLRLRKASVPMGVIGIIYEARPNVTFDVFALSLKSGNATVLKGGSDADASNRAIVELIHSVLSDHNLSPDTLYLLPSEREAATVMMGAVGKIDMIIPRGSQALINHVRNTAKVPVIETGAGIVHTYFDKSGELEMGKEIVLNAKTRRPSVCNALDTLIIHSERLGDLSELCRPLAEHQVIIFADERAYLSLLASYPEQLLQHAEPEHFGTEFLSLKLSVKTVDTLDDALEHIAAYSSQHSEAVITEDPAVKAEFFKRVDAAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALRELTTYKWMIEGDGQTRPA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_ENTFA
Sequence: MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLSERPQNKEVLHLTWAQTPEETGEFSGKRISPSEIYEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWKGNPKEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVRTTLPGEVVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSMYPLLWENMGLKYSDLIEELIQLALNRFK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_CAMC5
Sequence: MQSPHISVLLDEVLDAFHGLSGTFIDCTLGYGGHSGALLEQNKNLRLIACDKDDEAIEFSKKRLENFGDRVKIYKSDFSQLIKVLSTDELKNVRGILADIGVSSLQLDKNERGFSINSDTLDMRMDRACEFSAADVINSYSQQNLAEIFSKYGELSNAKALAAKIVSARNLKKITSAKELASIIGTGRVNGRSVSPAILAFQAIRVEVNDELGELNRLLESIKSANLKECKVAIISFHSLEDRIVKNTFKSWAQSCICPPNAMRCKCGNDHAIGKILTKKAIVASQKEIAANPRSSSAKMRVFEIKGR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHL13_ARATH
Sequence: MAERVYPADSPPQSGQFSGNFSSGEFPKKPAPPPSTYVIQVPKDQIYRIPPPENAHRFEQLSRKKTNRSNCRCCFCSFLAAVFILIVLAGISFAVLYLIYRPEAPKYSIEGFSVSGINLNSTSPISPSFNVTVRSRNGNGKIGVYYEKESSVDVYYNDVDISNGVMPVFYQPAKNVTVVKLVLSGSKIQLTSGMRKEMRNEVSKKTVPFKLKIKAPVKIKFGSVKTWTMIVNVDCDVTVDKLTAPSRIVSRKCSHDVDLW
What is the function of this protein?
Required for plant immunity against the bacterial pathogen Pseudomonas syringae pv.  tomato DC3000 (Pst DC3000).
What are the official names of this protein?
NDR1/HIN1-like protein 13.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MSRP_PASMU
Sequence: MHKLNENDVTPEHIFFERRKIIQSMGLMGAASLLPRFSLAAEKQDSRQALHFAKDHNPQNLLLTPENKVIGYNNFYEFGVDKASPAKYASALKTEPWTLRIEGEVEKPMTFDVHQLMQQLPLEERIYRFRCVEAWSMVIPWIGFELNKLLALVQPTSQAKYVEFETLYEPDSMPGQKNHFFGGGLIYPYVEGLTMAEAMHPLTLLSVGLYGKTLAPQNGAPIRLVVPWKYGFKNIKSIVKITLKSEQPMTTWHHAAPHEYGFYANVNPEVDHPRWSQASERVIGSGGLLSVKRQPTLLFNGYAEQVAHLYQDLDLRTYF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: NUOD_RUEPO
Sequence: MMDGGKGFEDALTGEQKIRNFNINFGPQHPAAHGVLRMVLELDGEIVERCDPHIGLLHRGTEKLMESRTYLQNLPYFDRLDYVAPMNQEHAWCLAIEKLTGVEVPRRASLIRVLYSEIGRILNHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERACGARLHAAYFRPGGVHQDLPDALLDDIEAWSHTFPNVLDDIDGLLTENRIFKQRNCDIGVVSEEEILQYGFSGVMVRGSGLAWDLRRAQPYECYDEFEFQVPVGKNGDCYDRYLCRMEEMRQSISIIRQAIAKLRDCPGDVLARGKLTPPKRGDMKTSMESLIHHFKLYTEGFHVPAGEVYAAVEAPKGEFGVYLVADGTNKPYRSKIRAPGYLHLQAMDHVARGHQLADVAAIIGTMDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.