PharMolix/UniProtQA huggingface dataset:
Protein: TLOV1_ARATH
Sequence: MSLTKSSESVFTEEEEEDSFSGRYTLWIKEALEELPHNFTITDPFISGHPIVFASLGFLKMTGYSREEVIGRNGKVFQGPKTNRRSIMEIREAIREERSVQVSLLNYRKSGSPFWMLFHMCPVFGKDDGKVTNFVAVQVPISGREHHRKKLRNVGDLSSDTSPTFGSCRREVCFGNFVCQDRALPVECDDDEQGLEDWEQCEASESEKLKATEAINNVLSILVHYSELSGRLVCGKRYCLRGVDCLSSSLVISLGRIKQSFVLTNPCLPDMPIIYASDAFLTLTGYKRQEVLGQNCRFLSGVDTDSSVLYEMKECILKGQSCTVQILNYSNRKDKSSFWNLLHISPVRNASGKTAYFVGVQVEASCRNTEIKELRPETRQLSVVGAVRVAVRSSLMVTC
What are the official names of this protein?
Protein TWIN LOV 1.
Protein: H2A1_ARATH
Sequence: MAGRGKTLGSGSAKKATTRSSKAGLQFPVGRIARFLKKGKYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRIVPRHIQLAVRNDEELSKLLGDVTIANGGVMPNIHNLLLPKKTGASKPSAEDD
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Probable histone H2A.1, HTA10.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NU2C2_ORYSI
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFQGSFIFPECILIFGLILLLMIDLTSDQKDRPWFYFISSTSLVISITALLFRWREEPIISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVALECFSLCSYLLSGYTKRDLRSNEATMKYLLMGGASSSILVYGFSWLYGLSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGLGFKLSLAPFHQWTPDVYEGSPTPVVAFLSVTSKVAALALATRILDIPFYFSSNEWHLLLEILAILSMILGNLLAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVLSIYYYLKIVKLLMTGRNQEITPYVRNYRRSPLRSNNSIELSMTVCVIASTILGISMNPILAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: YIBA_ECO57
Sequence: MSNTYQKRKASKEYGLYNQCKKLNDDELFRLLDDHNSLKRISSARVLQLRGGQDAVRLAIEFCSDKNYIRRDIGAFILGQIKICKKCEDNVFNILNNMALNDKSACVRATAIESTAQRCKKNPIYSPKIVEQSQITAFDKSTNVRRATAFAISVINDKATIPLLINLLKDPNGDVRNWAAFAININKYDNSDIRDCFVEMLQDKNEEVRIEAIIGLSYRKDKRVLSVLCDELKKNTVYDDIIEAAGELGDKTLLPVLDTMLYKFDDNEIITSAIDKLKRS
What are the official names of this protein?
Protein YibA.
Protein: CNO10_RAT
Sequence: MAADKPADQGAEKHEGAGQSSGVTDQEKELSTSAFQAFTSGNYDACLQHLACLQDINKDDYKIILNTAVAEFFKNNQTTTDNLRQTLNQLKNQVHSAVEEMDGLDDVENSMLYYNQAVILYHLRQHTEAIAVGEKLYQFIEPFEEKFAQAVCFLLVDLYILTHQAEKALHLLAVLEKMISQGSGNKNGKSETGNNSSKDGSNPKAESAALIEAAKSKIHQYKVRGYIQMKSLKACKREIKSVMNTAGNSAPSLFLKSNFEYLRGNYRKAVKLLNSSNIAEHPGFMKTGECLRCMFWNNLGCIHFAMSKHNLGIFYFKKALQENDNVCAQLSAGNTDPGKKFSGRPMCTLLANKRYELLYNCGIQLLHVGRPLAAFECLVEAVQVYHANPRLWLRLAECCIAANKGTSEQETKGLPTKKGIVQSIVGQGYHRKIVLASQSIQNTVYNDGQSSAIPVASVEFAAICLRNALLLLPEEQQDPKQENGSKSSSQLGGNAESSESSETCSSKSHDGDKLIPAPPSSPLRKQELENLKCSILACSAYVALALGDNLMALNHADQLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPENVTDVSLGISSNEQDQGSDKGENEAMESSGKRAPQCYPSSVNSARTVMLFNLGSAYCLRSEYDKARKCLHQAASMIHPKEVPPEAILLAVYLELQNGNTQLALQMIKRNQLLPAVKAHSDVRKKTVFQPVHPIQPIQMPAFTTVQRK
What is the function of this protein?
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.  Additional complex functions may be a consequence of its influence on mRNA expression.  Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
What are the official names of this protein?
CCR4-NOT transcription complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the CNOT10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SAC2_DANRE
Sequence: MELFQAKDHYILQSGDNALWCSRKDGSMAVRPATDLLLAWNPVCLGLVEGIIGKMQLHVDLPLGLILIRQKALVGQLPGDHKVYKITKIVVIPLSEDEPQDLELELCKKHHFGINKPERITQSPDETKFLMKTLSQIKSNVGAPIKKKVKENKEKERLERRLLDELYKIFMDSDSFYYSLTYDLTNTVQRQGELGKSDQPLWKRVDDRFFWNKHMIKDLVDLQAPQVDFWVIPIIQGFVQVEELVVNYNESSDEERSSPETPLQEPTCVDDIHPRFTVALISRRSRHRAGMRYKRRGVDTDGHVANYVETEQLIHVHSHTLSFVQTRGSVPVFWSQAGYRYNPRPRIEKGERETMPYFASHFEKEVETYKKLVIINLVDQNGREKIIGDAYLKQVLLYNNPNLTYVSFDFHEHCRGMKFENVQTLTDAIYDIITDMRWAWVDQAGVICQQEGIFRVNCMDCLDRTNVVQAAIARVIMEQQLKKLGVMPPEQPLPLKCYRIYQVMWANNGDTISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFRDAYRQAVIDLMMGHPVTEDLYSIFSKEKEHEEKEKESQRGAQEQVSLLLQTYMQLLLPDDEKFHGGWALIDCDPSLIDATHKDVDVLLLLSNSAYYVAYYDEEADKVNQYQRLSLEGLEKIEIGPEPTLFGKPKYCCMRLHYKNGETSGYFHTLRSVTRNPEDDGKDTLQCIAEMLRITKQAMGLDVQVVEKKLERRHSKPHEDIMGIQGKAVDQVLGSGLAQGKSFFLNKFSTLNQKVKQTKTNVNIGNFKPLGKLGTFSKPEVKVNFLKPNLHMNLWKSDSSLETHDSNTGSGALKDHGPHSEEISSDSDSYNSDEQPCSGSRENVDYVLPSCGIVASAPRLGSRSQSIGSVEIAVPSVIRVTGCDEKTMDSLSVAADQSPGAASEAEEAILIDFGTPIDVYCHQFVQDAKTKPIEVFEEVAPAPKPQGPQVPLAPDAKLGSSHSQNQLPRPSQLEVESNVHGANLLTVQPVGSATSCGSQKSLEGITGPSSADSNGSRVVSPFAKIRSSMVQVASLTQAGLTQGINFAVAKVQKSPEPDAVNETQENELRAMFTQCQTRIIQI
What is the function of this protein?
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate.  May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling.
What are the official names of this protein?
Phosphatidylinositide phosphatase SAC2, Inositol polyphosphate 5-phosphatase F, Sac domain-containing inositol phosphatase 2, Sac domain-containing phosphoinositide 4-phosphatase 2, hSAC2.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Early endosome. Recycling endosome. Note=Also found on macropinosomes.
Protein: KDM6A_HUMAN
Sequence: MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQMRPTGVAQVRSTGIPNGPTADSSLPTNSVSGQQPQLALTRVPSVSQPGVRPACPGQPLANGPFSAGHVPCSTSRTLGSTDTILIGNNHITGSGSNGNVPYLQRNALTLPHNRTNLTSSAEEPWKNQLSNSTQGLHKGQSSHSAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNILTVPETSRHTGETPNSTASVEGLPNHVHQMTADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGTGTCDKVNNIHPAVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPMKTDLLLVNHKPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849).  Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849).  Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529).  Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849).  Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).
What are the official names of this protein?
Lysine-specific demethylase 6A, Histone demethylase UTX, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein, [histone H3]-trimethyl-L-lysine(27) demethylase 6A.
What is the protein family that this protein belongs to?
Belongs to the UTX family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AMID_ECOLI
Sequence: MRRFFWLVAAALLLAGCAGEKGIVEKEGYQLDTRRQAQAAYPRIKVLVIHYTADDFDSSLATLTDKQVSSHYLVPAVPPRYNGKPRIWQLVPEQELAWHAGISAWRGATRLNDTSIGIELENRGWQKSAGVKYFAPFEPAQIQALIPLAKDIIARYHIKPENVVAHADIAPQRKDDPGPLFPWQQLAQQGIGAWPDAQRVNFYLAGRAPHTPVDTASLLELLARYGYDVKPDMTPREQRRVIMAFQMHFRPTLYNGEADAETQAIAEALLEKYGQD
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase AmiD.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: PYRH_PROM1
Sequence: MTYSRALIKLSGEALMGDKPYGIDPEIVQSIAKDVSKVVENGTQIAIVVGGGNIFRGLKGSAAGMDRATADYVGMLATVMNAITLQDGLERAGVPTRVQSAIDMQQIAEPYIRRRAIRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVFKATKVDGVYDRDPKKFTDAVKYDNLTFQDVLANEIGVMDSTAIALCKDNKIPIVVFNIFQPGNIAKAISGEPIGSRISNSS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRC19_LACTC
Sequence: MASRGITITTNKAITTSKSTLILKHDKFLPPRNMINEFPHDDVLRMCYRRHMRLKPFISQRSMIQTTYVDYVRYKYKNEDYPKKCRASGIAHKTPVQSVLQQAELSLRFCLQAVMQVKKGVSDERSVSNEIRLSRNMLKNILAIEHEKAKLIAQNPRQNYPILREAFSYISPTAHKSSLLLRFNALREFDRCLIRFNMCMGTKL
What is the function of this protein?
Involved in sporulation and maintenance of the mitochondrial DNA.  Is probably involved in a pathway contributing to genomic integrity (By similarity).
What are the official names of this protein?
Increased recombination centers protein 19.
What is the protein family that this protein belongs to?
Belongs to the IRC19 family.
Protein: UVRA_LEPIC
Sequence: MQEIRIRGAREHNLKNINVDIPRDQLVVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMEKPDLDLIEGLSPAISIEQKTTHRNPRSTVGTVTEIYDYLRLLYARVGKPHCPECGTPIQSMSIDQITARVLAFPQGSKLQILAPVISGKKGEHKDVLEKIRKDGFNRVRINGEIRTLEEEIVLKKNFKTSIEIVVDRIVMKEGIRSRLADSVETALKQSEGLVILDDGSKDHILSQKMACPNGHDIGFTELSPRMFSFNSPYGACETCDGLGSLLEFDEDLLVNDPELSLVDGCIEAWAGSKSNGFWFMATLKSLSDSLKFKMNTPWKDLPEKTRQTILYGDKKIKIEYDFRGANSHYEFTKEYEGVIPNLQRRYKETKSDSMRQWFESYMTNHPCPSCKGKRLKRESLSVKVHNVPVDEFTSYSIEKALNFVQNLKVTGAEEIIAKPILKEIHQRLSFLNDVGVGYLTLERSAGSLSGGEAQRIRLATQIGSRLMGVLYILDEPSIGLHQRDNTKLVSTLKNLRDLGNTVLVVEHDQETMEESDWLIDMGPGAGVHGGSIVCAGTPAEVSKHKNSLTGKYLSGRLKVPIPAKLREGNGSKLQIIGAKENNLKNIDVNIPLGKLVVITGVSGSGKSTLINDILYNAAAHKVMKMKTLAGKHKTIKGFENIDKIINIDQSPIGRTPRSNPATYTGLFTPIREMFAGLEEAKLRGYGPGRFSFNVSGGRCETCEGDGILKIEMHFLPDVYVTCEVCKGKRYNQETLEVRYKGKNIFDVLEMTVEDANQFFENIPIVKRKLETLLEVGLGYIRLGQPATTFSGGEAQRIKLATELSKRPTGKTLYILDEPTTGLHFEDVRRLSEVLHTLVDRGNSMIVIEHNLDVIKQADWIVDMGPEGGDGGGLVIAEGIPKDIAKIKNSYTGQYLKKIFTSSEKISRKTK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrA is an ATPase and a DNA-binding protein.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
What are the official names of this protein?
UvrABC system protein A, UvrA protein, Excinuclease ABC subunit A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. UvrA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OLEB_XANCP
Sequence: MTYPGYSFTPKRLDVRPGIAMSYLDEGPSDGEVVVMLHGNPSWGYLWRHLVSGLSDRYRCIVPDHIGMGLSDKPDDAPDAQPRYDYTLQSRVDDLDRLLQHLGITGPITLAVHDWGGMIGFGWALSHHAQVKRLVITNTAAFPLPPEKPMPWQIAMGRHWRLGEWFIRTFNAFSSGASWLGVSRRMPAAVRRAYVAPYDNWKNRISTIRFMQDIPLSPADQAWSLLERSAQALPSFADRPAFIAWGLRDICFDKHFLAGFRRALPQAEVMAFDDANHYVLEDKHEVLVPAIRAFLERNPL
What is the function of this protein?
Involved in olefin biosynthesis (PubMed:28029240, PubMed:28223313).  Catalyzes the elimination of carbon dioxide from beta-lactones to form the final olefin product (PubMed:28029240).
What are the official names of this protein?
Cis-3-alkyl-4-alkyloxetan-2-one decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_SHESW
Sequence: MTQEGKRILVMAGGTGGHVFPALAVAKYLAQQGWQVRWLGTADRMEARLVPQYGFDIDFIDIKGVRGNGLVRKLAAPFKVIRSILQAKAVIAEFKPDVVLGMGGFASGPGGVAARLAGIPLVLHEQNAIPGMTNKLLSRIATQVLCAFKNTFTTVKSKVVGNPIRRELIALGAEPKPLADDALKVLVVGGSLGAKIFNDLMPSVVAALSKQQSITVWHQVGKDNLAGVKAAYQQQGQEGGVNIAEFIDDMEAAYRWADVVLCRAGALTVSELAAVGLPSILVPYPHAVDDHQTRNGQVLVEAGAAFLLPQAILDVDKLVGKLQLLANDRTELARMGQRARDVAVLDATEQVAAVCISLAEKG
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ALLA_BRUSI
Sequence: MQIETLTVEPLTKEAFAPFGDVIEVEGAQLRLINNGTTERYHDLARVEAAGTQTRVLINIFRGQSFAAPIDIMMMERHPFGSQAFIPLNGRPFLVVVAEDAGAGPARPRAFLARGDQGVNYLRNIWHHPLLALEQKSDFLVVDRAGREDNLEEYFFSDYAYRIETTQTA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: HEXI1_MOUSE
Sequence: MAEPLLTEHQHQPQTSNCTGAAVVHEEHTSERPPSAEERVPKEDSRWQSRASLQSGSRPGQEGEGGLKHQLPPLQTNACPELSSLEKGEKGQNGEDLSTGGASPSAEGEPMSESLVQPGHDSEATKQEAPAAGGEEPWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYPKRAAAKSDDTSDEDFVEEAGEEDGGSDGMGGDGSEFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSRKEDENNRLRLESKRLGGVDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD
What is the function of this protein?
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor.  Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.  May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.  Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
What are the official names of this protein?
Protein HEXIM1, Cardiac lineage protein 1.
What is the protein family that this protein belongs to?
Belongs to the HEXIM family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear.
Protein: FUS_NDVB1
Sequence: MGSRPFTKNPAPMMLTIRVALVLSCICPANSIDGRPFAAAGIVVTGDKAVNIYTSSQTGSIIVKLLPNLPKDKEACAKAPLDAYNRTLTTLLTPLGDSIRRIQESVTTSGGGRQGRLIGAIIGGVALGVATAAQITAAAALIQAKQNAANILRLKESIAATNEAVHEVTDGLSQLAVAVGKMQQFVNDQFNKTAQELDCIKIAQQVGVELNLYLTELTTVFGPQITSPALNKLTIQALYNLAGGNMDYLLTKLGIGNNQLSSLIGSGLITGNPILYDSQTQLLGIQVTLPSVGNLNNMRATYLETLSVSTTRGFASALVPKVVTQVGSVIEELDTSYCIETDLDLYCTRIVTFPMSPGIYSCLSGNTSACMYSKTEGALTTPYMTIKGSVIANCKMTTCRCVNPPGIISQNYGEAVSLIDKQSCNVLSLGGITLRLSGEFDVTYQKNISIQDSQVIITGNLDISTELGNVNNSISNALNKLEESNRKLDKVNVKLTSTSALITYIVLTIISLVFGILSLILACYLMYKQKAQQKTLLWLGNNTLDQMRATTKM
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: HSL14_DICDI
Sequence: MTLLASISTIGNVKSISKSNNFSSLSNSSLQSSNSIQCGGCGGGNSLIGTVGGLVGGVLVGTGIIVGTVIGTVNGVVGGLLSGPSCGCH
What are the official names of this protein?
HssA/B-like protein 14.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: NUOCD_PSEPK
Sequence: MTADNAIFIPPYKADDQDVVVELNNRFGADAFVAQETRTGMPVLWVKRAQLKEVLSFLRGVAKPYSMLYDLHGVDERLRTQRRGLPAADFSVFYHLLSIERNSDVMIKVSLSEGDLNLPTVTGIWPNANWYEREVWDMFGIDFAGHPHLSRIMMPPTWEGHPLRKDYPARATEFDPYSLTLAKQQLEEESARFNPEAWGMKRQGANEDYMFLNLGPNHPSAHGAFRIVLQLDGEEIVDCVPDIGYHHRGAEKMAERQSWHSFIPYTDRIDYLGGVMNNLPYVLAVEKLAGIKVPQKVDVIRIMLAEFFRITSHLLFLGTYIQDVGAMTPVFFTFTDRQRAYTVIEAITGFRLHPAWYRIGGVAHDLPRGWDKLVKDFVEWLPKRLDEYTKAALQNSILKGRTIGVAAYNTKEALEWGTTGAGLRATGCNFDLRKARPYSGYENFEFEVPLAHNGDAYDRCMVRVEEMRQSIRIIDQCLRNMPEGPYKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGGTMSYRTRIRTPSYPHLQQIPSVIKGSMVADLIAYLGSIDFVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL11_DEHMC
Sequence: MAKKVKAIVKLQIPAGKANPAPPIGPALGQHGINIMGFCKEYNERTASMVGTIVPAEITIYDDRSFTFITKTPPAADLLKKAAGVTSGSGTPSKSVVAVISKGQLREIASVKMKDLNAVNIEGAERIIEGTARSMGIKVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CUTA_SALPK
Sequence: MLDVKSQDISIPEAVVVLCTAPDEATAQDLAAKVLAEKLAACATLLPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALIDCLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
What is the function of this protein?
Involved in resistance toward heavy metals.
What are the official names of this protein?
Divalent-cation tolerance protein CutA.
What is the protein family that this protein belongs to?
Belongs to the CutA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPT35_ASHGO
Sequence: MPHIQFLPPEPVVLVSRVADDPDPAGPGLHVAKVAVGDCTIVDARTPCAPLQGRFAVWTVALQLHSPDTPRSLTLRKRYSDFVRFRERLLLCLPPPLRRAVPPLPPPVPWYDAWRYSDVNLDRAWLAARRAGLERFLQQVLLNRALVAAAPVVVRGFLEPPAAHRWVPVRA
What is the function of this protein?
Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
What are the official names of this protein?
Endosomal/vacuolar adapter protein YPT35, PX domain-containing protein YPT35.
What is the protein family that this protein belongs to?
Belongs to the YPT35 family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Protein: RPPH_YERE8
Sequence: MIDDDGYRPNVGIVICNRQGEVLWARRYGQHSWQFPQGGINPGETPEQAMYRELFEEVGLNKKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQRWFLLQLMCNEADINMQRSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFAPTVMPVQEAAPPRVPPAYRRKRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: TX316_LYCSI
Sequence: MKFVLLFGVLSLTLFSYSSAEMLDDFDQADEDELLSLIEKEEARAKECTPRFYDCSHDRHSCCRSELFKDVCTCFYPEGGDNEVCTCQQPKHLKYMEKAADKAKKFGGKIMKWFS
What are the official names of this protein?
U3-lycotoxin-Ls1e, Toxin-like structure LSTX-B16.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GSH1_JANMA
Sequence: MSNLFTRRLALLADDAHRDLLNQGRRGIERETLRVDLQGKLALGPHPVALGSALTNPQITTDYSESLLEFITPAEHDVATALEELDRIHRFANAKLDHELLWSQSMPCTLPEEADIPIAWYGTSHIGMIKHVYRRGLALRYGKAMQCIAGLHYNYSLSEDLWRVIKQSEQSRLDDKSYQSESYISLIRNFQRYSWLLMYLFGASPALSTHFLRGREHELQTLSDDTLYLPYATSLRMSDLGYQNNAQAGLMPPYNDLESYMRSLSRAVRQAYPAYEAIGTRRNGEWIQLNTNLLQIENEYYATIRPKRVINSGERPVEALCARGVQYIEVRCMDIDPFEPLGISLPTSRFLDAFLLFCALDDSPLTDEANNRERTENFARTVKEGRRPGLLLQRDGAAVKLQDWGLELLERIQATADLLDAQRADSQHAQALAAQKEKLLDAGLTPSARVLAELQATDKSFEQFGLRQSIAHAEYFRARPLNAEENFYFETLAKTSIAEQEEMERTQSGDFDAFVEAYNQRTPQQLCD
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.