Protein: DPY26_CAEEL
Sequence: MDVPSSSNVTGRRKRQVLDDDEDDGFRSTPLRKVRGTKKIRPADVVPETIMTKIGAHIDDIVNKKKVGELNCFEYKSPLEIHTIEDMIKAKASIQEMAVVLEGAQCIIGYRVDRLHHDVRQIDSALSSGTVMRDSNGEEIHLTLESRKAKKKMAVVDGMNGMLDFLNNMDDALTTTELDADNDKNWKEDEENIAGEPRIDFKANSKDVDAFLQRDIFPEKLIYALSIKRATDLRADLLSDVSNYISADDTAHDLKDANIDWLRANPTFQKATKGSVCNSSNSFHSLNYYGIHSPDGRTLMLHNRIADKNADDRFFTSDVSVSLVKNTRALLTNSLDKKPRILDNYLMLEVKDRPVIGRYKIMSKDVKKSTLPLAESSREKDLANLTFAEMNHRPSNLDMTVAGASDMSMLPGNQGLPLAQGENDETIALDRLTPPLQSSVSQKASDEYVLPPLEANDLDEHLIGKLPIEPNEMDQTLANMFDKKLEVFNTSDTLESKVWKNGIRAEEWGEDDEAIMKNDTKHPRQAGIEGWIKATDAWTNYDVVKMNVNREARSQLDENAIDEQESYRNMVPEIGKNLFLVKSDDYMNNYPGDRPADFTVNDEVSDVMKMWSGEDSTAEDDVPLEQIQQEIREQVQQQDVDMEPIEEMDYDAGGAAFDVDFDDRLAAPVEVEEMEGDNNRNDGRVADILFNEQMDETEVEERNEQDVQRELEDIALAADEVAELMTSAPPPQLVGPSAEMREEIQNIGKNDNAHWVPPVVGDQERQAAVTAQRKRREKKAKSRKATVEDFVHYFRDIPDDEIEREITAAKCSKIADEKSTFLSEQQLYLPTLGIENKPHVAFEMGLLGNSGMFFKKSYGKIRLERVKNQKAEQDLFIDEARGNKDSDCLNWLLSFSGFRCMENPEPITGSDSDENLRTAVEQPFDDDFANDYYDEDRYDPNYEQQLAAAQMGPDMQRKLALTASHINQMFPNIHSKRYGGEYGDSDDEFDDSFDRQSIQAKNLDAAKHKKCLAEILKTDSLSMPSIQYVLEQLTSNQTLRMNNTTIRAADDRNETGRPATPTMEADKTLTSVFDYRSPNKSNHDVNETMKALTEMPDYQAADERPNNQPTTSTYGTANTENRKVHINGCHTLLSLALSMPSRMGETVRPSSIVSFLLHIANENNLQIVQDRSKRSWMSDFIVLNSSESLPRGLKMGRIEDQDEFWKRTQDPDAIEGTASDANNVFSNLMRRPKAVPVRKGRGAGGQPTTSDLGAIVEEEEMEE
What is the function of this protein?
Required for both chromosome condensation and segregation and for X-chromosome dosage compensation depending on its binding partners (PubMed:8939869, PubMed:8939870, PubMed:19119011, PubMed:2917714, PubMed:19781752).  Member of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes and for proper chromosome segregation in mitosis and meiosis (PubMed:19119011, PubMed:19781752).  As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure (PubMed:19781752, PubMed:18198337).  Plays a role in robust cytokinesis upon presence of chromatin obstructions (PubMed:23684975).  Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization (PubMed:19119011, PubMed:8939870, PubMed:2917714, PubMed:19781752).  As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites (PubMed:11937488).
What are the official names of this protein?
Condensin complex subunit dpy-26.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=During meiosis and mitosis, localizes to condensed chromosomes (PubMed:8939869). In interphase cells, diffusely distributed in nuclei of hermaphrodite embryos prior to the onset of dosage compensation (PubMed:8939869). Localizes to the X chromosome after the 40-cell stage when dosage compensation is initiated in hermaphrodite (XX) but not in male (X0) embryos, where it remains diffusely nuclear (PubMed:8939869, PubMed:18198337).