PharMolix/UniProtQA huggingface dataset:
Protein: ILVD_PSEA8
Sequence: MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLASHGLDLVDAMVVAADDSCSDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADREQLFLRAGRLAVELCQRYYGEGDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEVPFDLRDIDRLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGELARGGLLHTDVPTVHSPSMADAIAQWDITQTRDEAVHTFFKAGPAGIPTQTAFSQNTRWPSLDDDRAEGCIRSVEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDAAVKGILGDEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLVSDEELAARRAEQDKKGWKPAAPRARRVSTALKAYALLATSADKGAVRNKALLDG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ANGL4_HUMAN
Sequence: MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVLAHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVLHSLQTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPARRKRLPEMAQPVDPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKMTSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQLRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHDLRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQATTMLIQPMAAEAAS
What is the function of this protein?
Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144).  Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697).
What are the official names of this protein?
Angiopoietin-related protein 4, Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein, HFARP.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space, extracellular matrix. Note=The unprocessed form interacts with the extracellular matrix (PubMed:17068295, PubMed:21398697). This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (Probable).
Protein: CMOB_PSEMY
Sequence: MMRDLDLDALQAQLAGTPLQEWACELPGQLDAKLAIGHGDLARWYGAVQALPALPVSEVELARRFAFGGACDDASRAQLKTALQGLIPWRKGPFELFGVHIDTEWRSDWKWQRVAPHLDLTGKRILDVGCGNGYYMWRMLGAGAGSVVGIDPNWLFLCQFLAMKRYLPEQPVWHLPLAFEELPAKLQGFDTVFSMGVLYHRRSPIDHLLDLKDALVKGGELVLETLVVEGDAEQVLVPEDRYAQMRNVWFLPSVPALERWLRRAGFEDVRCVDVSTTSVDEQRATEWMRFQSLPEFLDPADHSRTVEGLPAPTRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: MPK1_CAEEL
Sequence: MPTWIPNNLCAQPTTRNAKPPSNGHPQATQQQSAPGSLAYRNSSNIPNGATNHVRQQKWQYTRSGHRKMADGEAVISTVNNVEEVHGQLFEVAPRYVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRFKHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDPGDEPVCEEPFTLEMEFDDLPKEKLKELIWEEAEAHHRRMEAEAAARNNGGQNPV
What is the function of this protein?
Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably upstream of rskn-1.
What are the official names of this protein?
Mitogen-activated protein kinase mpk-1, MAP kinase sur-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: RL32_ECOLU
Sequence: MAVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: LEUC_XYLFT
Sequence: MAGKTLYGKLWDIHEVARRDDGSSLIYIDRHILHEVTSPQAFEGLRLAGRPLWRVNANIATPDHNVPTTKAERQGSLLSIADTVSRLQVQTLDENCDDFGIFEFKMNDVRQGIVHVIGPEQGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVTQKMKNMQVRVEGTLPWGVTAKDIVLALIGKIGTAGGNGYAVEFSGSTIRALSMEGRMTICNMAIEAGARVGMVAVDEKTIQYVHGRPFAPKGSDWDAAVAFWRGLVSDPDAHFDRVVELSAEEIKPQVTWGTSPEMVSAVDQSVPDPERETDPVKKESLIRALKYMGLQPNDPITSIKLDRVFIGSCTNSRIEDLRAAAEVVKGRKVASTVKQAMVVPGSGLVKAQAEVEGLDKIFIEAGFEWREPGCSMCLAMNPDKLGSGEHCASTSNRNFEGRQGIGGRTHLVSPAMAAAAAVAGHFVDVREMMR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: YPU3_RHOCA
Sequence: MPALKSHVRPNSAAPARRQPWPCGSCVTAPVAVRIGAMGASPGPARRPHHRGCRA
What are the official names of this protein?
Uncharacterized 5.8 kDa protein in puhA 5'region, ORF55.
Protein: SYT_STRMU
Sequence: MIKITFPDGAVREFEIGTTTSEIAESISKSLAKKALAGKFNGQLIDTTRAITQDGSIEIVTPDHEDALDILRHSAAHLFAQAARRLFPDIHLGVGPAIQDGFYYDTDNEAGQISNEDLPRIEEEMKKIVKENFPSVREEVTKDEAREIFKNDPYKLELIEEHSEDAGGLTIYRQGEYVDLCRGPHVPSTGRIQVFHLLNVAGAYWRGDSNNAMMQRIYGTAWFDKKDLKSYLKRLEEAKERDHRKLGKELDLFMISQEVGQGLPFWLPDGATIRRIIERYITDKEVASGYQHVYTPPIASVDLYKTSGHWDHYREDMFPTMDMGDGESFVLRPMNCPHHIEVYKNHVHSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVALDQVEDEFKRTLQLIIDVYEDFNLTDYSFRLSYRDPNDTHKYFDDDEMWEKSQTMLKAAMDDMGLDYYEAEGEAAFYGPKLDIQVKTALGNDETLSTIQLDFLLPERFELTYIGADGEEHRPVMIHRGIVSTMERFTAYLIETYKGAFPTWLAPHQVTVIPISNEAHIDYAWEVAKELRDHGIRADVDDRNEKMQYKIRQSQTKKVPYQLIVGDKEVENGTVNVRRYGSKQTHTESIAEFRENILADIKRKSRPDNAK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBD_PINKO
Sequence: MTITLGKSSKEEQTLFDTVDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSAPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGSWMSAIGVVGLALNLRAYDFVSQEIRAAEDPESETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RS7_MACCJ
Sequence: MPRKGPVAKRDVLPDPIHNSKLVTKLINKIMIDGKRGTAQKILYNAFDLVQERSGRDAMEVFEEAINNIMPVLEVKARRVGGSNYQVPVEVRAERRTTLGLRWLVNYSRLRGEKTMEERLANEILDAANNTGGAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: NUSB_STRS7
Sequence: MTKRFQHSRRDLRERAFQALFTMEMGGDFLLASQFAYDYDKEVADDKQPSELPVFLLNLVNGVMDHKAELDEVIKKNLKAGWSIERLTVVDKTMLRLGLFEMTLFEETPDRVALNEIIEIAKKYSDDTSAKFINGLLSQFVSDESAAVTD
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: SYR_BRUO2
Sequence: MNIFADFDARIKKTLQDIDLKPKDGGELDLSRIGVEPPRDASHGDIATNAAMVLSKAVGQNPRELAARIAEALKADEDVESVDVAGPGFINLRLKASYWQRELLVMLNEGTDFGRSRLGAGKKVNVEYVSANPTGPMHVGHCRGAVVGDVLANLLKFAGYDVVKEYYINDAGAQIDVLARSVMLRYREALGESIGEIPAGLYPGDYLVRVGQELAGEFGTKLLEMPEAEALAIVKDRTIDAMMAMIRADLDALNVHHDVFYSERKLHVDHARAIRNAINDLTLKGHVYKGKLPPPKGQLPGDWEDCEQTLFRSTEVGDDIDRPLMKSDGSFTYFAGDVAYFKDKYDRGFNEMIYVLGADHGGYVKRLEAVARAVSDGKAKLTVLLCQLVKLFRNGEPARMSKRAGEFITLRDVVDEVGRDPVRFMMLYRKNDAPLDFDFAKVTEQSKDNPVFYVQYASARCHSVFRQAADQLGLVDLDRVAMGSHFEKLTDESEIALVRKLAEYPRLIESAAIHQEPHRLAFYLYDLASSFHSQWNRGTENPDLRFIKVNDPDLSLARLGLVQVVSDVLTSGLTIIGADAPTEMR
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NYV1_YEAST
Sequence: MKRFNVSYVEVIKNGETISSCFQPFQKNENYGTITSANEQITPVIFHNLIMDMVLPKVVPIKGNKVTKMSMNLIDGFDCFYSTDDHDPKTVYVCFTLVDMPKILPIRILSGLQEYESNATNELLSSHVGQILDSFHEELVEYRNQTLNSSGNGQSSNGNGQNTISDIGDATEDQIKDVIQIMNDNIDKFLERQERVSLLVDKTSQLNSSSNKFRRKAVNIKEIMWWQKVKNITLLTFTIILFVSAAFMFFYLW
What is the function of this protein?
Vacuolar v-SNARE required for docking.  Only involved in homotypic vacuole fusion.  Required for Ca(2+) efflux from the vacuolar lumen, a required signal for subsequent membrane fusion events, by inhibiting vacuolar Ca(2+)-ATPase PMC1 and promoting Ca(2+) release when forming trans-SNARE assemblies during the docking step.
What are the official names of this protein?
Vacuolar v-SNARE NYV1, R-SNARE NYV1, New v-SNARE 1, Synaptobrevin NYV1.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type IV membrane protein.
Protein: EIF3F_CULQU
Sequence: MSTINLPLNLTVRVHPVVLFQIVDAYERRNADSERVIGTLLGSVEKGIVEVTNCFCVPHKEHADQVEAELGYASDLYDLNRRVNPSENIVGWWATGQEVTNHSSVIHEYYARECNNPIHLTLDTSLTAARMGIKAYVCVSLGVPGGKTGCMFTPINVEVTSYEPEVVGLSLCAKTIGVQSNPARPRTVSPMLDLAQVSEASGKLQTLLGEVLNYVEDVLAEKQQPDNFVGRALLDLIHSVPNMKHEEFAKMFNSNVKDLLMVVTLSQLIKTQLQLNEKLTSLTSFLS
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit F, eIF3f, Eukaryotic translation initiation factor 3 subunit 5.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit F family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END4_ECO81
Sequence: MKYIGAHVSAAGGLANAAIRAAEIDATAFALFTKNQRQWRAAPLTTQTIDKFKAACEKYHYTSAQILPHDSYLINLGHPVAEALEKSRDAFIDEMQRCEQLGLSLLNFHPGSHLMQISEEDCLARIAESINIALDKTQGVTAVIENSAGQGSNLGFKFEHLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLRTPAECEKTFADFARIVGFKYLRGMHLNDAKSTFGSRVDRHHSLGEGNIGHDAFRWIMQDDRFDGIPLILETINPDIWAEEIAWLKAQQTEKAVA
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: NHRF2_HUMAN
Sequence: MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF
What is the function of this protein?
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.  Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453).  May also act as scaffold protein in the nucleus.
What are the official names of this protein?
Na(+)/H(+) exchange regulatory cofactor NHE-RF2, NHERF-2, NHE3 kinase A regulatory protein E3KARP, SRY-interacting protein 1, SIP-1, Sodium-hydrogen exchanger regulatory factor 2, Solute carrier family 9 isoform A3 regulatory factor 2, Tyrosine kinase activator protein 1, TKA-1.
What are the subcellular locations of this protein?
Endomembrane system; Peripheral membrane protein. Nucleus. Apical cell membrane. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern.
Protein: 6PGL_HELPJ
Sequence: MGYQLFEFENLEDCHKALIERFKEFFNAALKKHHQVSVAFSGGRSPISLLQKLSVLDLKWHECLISLVDERIIEASHEDSNAKLLHDYLLQNNALKASFTPLLPEKISGDTNELLDFANQHFKQPHLAILGMGTDGHTASLFPETSAFLNEEKENIVLTKPTNAPYERLSMSINALENCEKLFLSISGVEKRGVLEKALKENAPYSLPIARILHSKKVTTEVFYAKN
What is the function of this protein?
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6PGL.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Protein: TRPF_ZYMMO
Sequence: MSVRTKICGLSTEETVATAVRYGADYIGFVFFEKSPRSVTPEKAAMLIRQIPDHVQKMGVFVDPDNNLLERALASGLTGFQLHGHETAERIASIRETFPKVKIWKALSIANSQDLAQAPHYRGLADRLLYDARTDGVLPGGMGRRFDWRLLKEYKHPLPWALSGGLDANNIAQAVAITGAELVDISSGVETSPGIKDMDKIAQFLQAVRLL
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: MOB1A_HUMAN
Sequence: MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR
What is the function of this protein?
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  Stimulates the kinase activity of STK38 and STK38L.  Acts cooperatively with STK3/MST2 to activate STK38.
What are the official names of this protein?
MOB kinase activator 1A, Mob1 alpha, Mob1A, Mob1 homolog 1B, Mps one binder kinase activator-like 1B.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
Protein: ILVD_BACC7
Sequence: MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGEVVDLSSVFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKEAAEKLKVLIERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAHEAGLDYDMSRIDAVSRRVPHLCKVSPASNWHMEDIDRAGGISAILKEMSRKEGVLHLDRITATGQTLRENIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHISPEAAAGGTIALLEQGDIVCIDVEERLLEVRISDEELDKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKVPNFD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: LEPA_THEP3
Sequence: MSERMQYIRNFCIIAHIDHGKSTLADRLIEKTGFLSERETDKQILDNLELERERGITIKLKPVRMIYKAKDGNEYELNLIDTPGHVDFTYEVSRSIAACEGALLVVDATQGIEAQTLANVYMALEHDLEIVPVINKIDLPSANPEHVKKEIEDVIGIDAEDALLTSAKEGIGIEEVLEAIVNRIPPPKGDENKPLKALIFDSFYDNYKGAISFVRVVDGIVKPGMRIKMFSTGKVFEVTEVGMFRPNLYPVEELKSGEVGYIAASIKNVKDTRVGDTITDADNPADSPLPGYKEVVPMVFCGIYPADGQDYENLKEALEKLQLNDASLVFEPDTSAALGFGFRCGFLGLLHMEIVQERLEREYNLNLVTTAPSVIYKVYKTNGEVLDLDNPTKMPPPTQIDHIEEPIVEATIMVPTEYVGAIMELCQDRRGVYLGMEYLEQTRVLLKYEMPLNEIIYDFFDALKSRTRGYASFDYELKGYKESNLVKLDILINGELVDALSMIVHKDKAYEKARKIVEKLKENIPRHLFEIPIQAAIGSKIIARETVKALRKNVLAKCYGGDVTRKKKLLEKQKEGKKRMRQVGSVEIPQEAFMSILKLDDEK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATG7_KLULA
Sequence: MLNDLKFSPAFKSFVDTSFFHELSRLKLEVFKLDSAEKELFSALDLENITSNTVSLSLRDDSFDPVLNNEAVTLKGSVLNFNTIESFKSCDKVKFIKEKGQQLLEQGLKNGLKECVRFYVISFADLKKYKFYYWVCMPTFQSEGSSYEIISTKSIEDGVKKDIWEQNSFISCVVDGKIQEASPQYLKVCQKVIFKDFSRLKGIPAAVTKNFLTVWSQISTRNTYTICFLRDDNSSFAAEIRVTGSNTGCLKVSGWEKNGLGKLAPKSADLSSLMDPVKIAEQSIDLNLKLMKWRIAPDIDLERIKNIKALILGSGTLGCYVARALLAWGTRHVTFVDNSTVSFSNPVRQPLFNFEDCGRPKAEAASDSLKKIFPSVVSAGYQLEIPMIGHPVSNESKQRKDYEILDELIRTHDVIFLLMDARETRWLPSVLGRMHEKIVINAALGFDSYLVMRHGNNNDNLGCYFCNDIVAPSDSLTDRTLDQMCTVTRPGVALLAASQAVELLVTYLQPSTNVLGSAPHQIRGFLNEFKTVKLETPAYQHCCASNENVILTLKENGWNFVKQALDDYKCVEQLSGLSKVQEEAELAIQEDISFDDDEELSIE
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: P2Y14_RAT
Sequence: MDNTTTTEPPKQPCTRNTLITQQIIPMLYCVVFITGVLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLSDSGLGPWQLNVFVFRVSAVIFYVNMYVSIAFFGLISFDRYYKIVKPLLVSIVQSVNYSKVLSVLVWVLMLLLAVPNIILTNQSVKDVTNIQCMELKNELGRKWHKASNYVFVSIFWIVFLLLTVFYMAITRKIFKSHLKSRKNSISVKRKSSRNIFSIVLAFVACFAPYHVARIPYTKSQTEGHYSCQAKETLLYTKEFTLLLSAANVCLDPISISSYASRLEKS
What is the function of this protein?
Receptor for UDP-glucose coupled to G-proteins.
What are the official names of this protein?
P2Y purinoceptor 14, P2Y14, G-protein coupled receptor 105, UDP-glucose receptor, VTR 15-20.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLGC_MYCBP
Sequence: MREVPHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFVLSNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGSADAIYQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVRFHIDSGAGATVAGIRVPRENATAFGCIDADDSGRIRSFVEKPLEPPGTPDDPDTTFVSMGNYIFTTKVLIDAIRADADDDHSDHDMGGDIVPRLVADGMAAVYDFSDNEVPGATDRDRAYWRDVGTLDAFYDAHMDLVSVHPVFNLYNKRWPIRGESENLAPAKFVNGGSAQESVVGAGSIISAASVRNSVLSSNVVVDDGAIVEGSVIMPGTRVGRGAVVRHAILDKNVVVGPGEMVGVDLEKDRERFAISAGGVVAVGKGVWI
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: HVCN1_HUMAN
Sequence: MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN
What is the function of this protein?
Mediates the voltage-dependent proton permeability of excitable membranes.  Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient.  Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
What are the official names of this protein?
Voltage-gated hydrogen channel 1, Hydrogen voltage-gated channel 1, HV1, Voltage sensor domain-only protein.
What is the protein family that this protein belongs to?
Belongs to the hydrogen channel family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.