PharMolix/UniProtQA huggingface dataset:
Protein: TRPB_BUCSC
Sequence: MTLLNSYFGSFGGMYVPQILMPALYQLESEFVLSLKNLQFKKKLANLLKNYAGRPTPLTLCRNLTKGTNTRIYLKREDLLHGGAHKTNQVLGQALLAKQMKKKEIIAETGAGQHGVAAALSCALLNLKCRIYMGIKDIERQKQNVFRMKLMGAQVIPVKSGNGTLKDACNEALRDWSENYINAHYMLGTAAGPHPYPTIVKQFQSVIGKETKQQIFEKEHCLPNSVIACVGGGSNAIGIFSSFIEDTSVNLIGVEPGGIGIHTEKHGASLICGETGIFFGMKSKVMQTHEGQIKESWSISAGLDFPAVGPEHAWLDSIKRVTYVSITDSEAVHAFQHLSKLEGIIPALESSHALAYAIKLMNNYPNKNQTLIVNISGRGDKDLKTVEKFLNK
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: HSCA_AZOVD
Sequence: MALLQIAEPGQSPQPHQRRLAVGIDLGTTNSLVATLRSGLAESLKDTEGETILPSAVRYLPDGRVEVGRAAKAAAAVDPLNTVLSVKRLMGRGIADVKLLGEQLPYRFAEGESHMPFIETVQGPKSPVEVSAEILRVLRRRAEEALGGELVGAVITVPAYFDEAQRQATKDAARLAGLDVLRLLNEPTAAAVAYGLDRGAEGVVAIYDLGGGTFDISILRLTRGVFEVLATGGDSALGGDDFDHAIANWIVEQAGLSADLDPGVQRHLLQLACAAKEALSDSGSVALAYGPWQGELSRERFEALIEPLVARSLKACRRALRDAGIEPQEIAAVVMVGGSTRVPRVRRAAAELFDRQPLTDIDPDQVVAIGAALQADTLAGNGRDGEELLLLDVNPLSLGLETMGRLMEKVIPRNTTLPVARAQEFTTYKDGQTAMLIHVLQGERELVKDCRSLARFELRGIPPMVAGAAKIRVTFQVDADGLLNVSARELGSGIEASVQVKPSYGLTDGEIARMLKDSFEYAGGDKAARALREQQVEAQRLLEAVQAALEADGEALLSPAERAAIEAQMQALRGVLDGPDAAVIETHVRHLTQVTDAFAARRLDASVKAALSGRRLNEIEE
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CLPS_HYDCU
Sequence: MPSQPFQDDGVVLETARPKVKPPKRYQVVLLNDDFTPMDFVVDVLTRFFGMDEAKANAVMLAVHTKGKGTCGVYSREVAEMKVMQVNQYAREHQHPLQCEMEVV
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: USTO_ASPFN
Sequence: MPIFYESLSDNLRDWALRQPLFFVSSAPYRGRHINVSPKGLPDSSFAVLSPSKVAYVDSTGSGCETICHLRENGRATVMFCSFDATPRIMRLFCTGSVIEWNDPRYAGYVKRMGVKSLVGARAVIILDIFKVQISCGFGVPLLDLTVDPETNEPKPCFTNRPRLGKFAEYTINRGELPEYQMQWNSRSLDGLPGLHSAMRDKGEFIWWAHVTNWASYYHFQLDIIKTGMALMFLVMVVAQWVGYVLYQW
What is the function of this protein?
Pyridoxamine 5'-phosphate oxidase family protein; part of the gene cluster that mediates the biosynthesis of the secondary metabolite ustiloxin B, an antimitotic tetrapeptide (PubMed:24841822, PubMed:27166860, PubMed:26703898).  First, ustA is processed by the subtilisin-like endoprotease Kex2 that is outside the ustiloxin B gene cluster, at the C-terminal side of Arg-Lys, after transfer to Golgi apparatus through the endoplasmic reticulum (ER) (PubMed:24841822).  Cleavage by KEX2 generates 16 peptides YAIG-I to YAIG-XVI (PubMed:24841822).  To process the precursor peptide further, at least two peptidases are necessary to cleave the N-terminal and C-terminal sides of the Tyr-Ala-Ile-Gly core peptide which serves as backbone for the synthesis of ustiloxin B, through cyclization and modification of the tyrosine with a non-protein coding amino acid, norvaline (PubMed:24841822).  One of the two peptidases must be the serine peptidase ustP; and the other pepdidase is probably ustH (PubMed:24841822).  Macrocyclization of the core peptide derived from ustA requires the tyrosinase ustQ, as well as the homologous oxidases ustYa and ustYb, and leads to the production of the first cyclization product N-desmethylustiloxin F (PubMed:27166860, PubMed:26703898).  For the formation of N-desmethylustiloxin F, three oxidation steps are required, hydroxylation at the benzylic position, hydroxylation at either the aromatic ring of Tyr or beta-position of Ile, and oxidative cyclization (PubMed:27166860).  UstQ may catalyze the oxidation of a phenol moiety, whereas the ustYa and ustYb are most likely responsible for the remaining two-step oxidations (PubMed:27166860).  N-desmethylustiloxin F is then methylated by ustM to yield ustiloxin F which in turn substrate of the cytochrome P450 monooxygenase ustC which catalyzes the formation of S-deoxyustiloxin H (PubMed:27166860).  The flavoprotein monooxygenases ustF1 and ustF2 then participate in the modification of the side chain of S-deoxyustiloxin H, leading to the synthesis of an oxime intermediate, via ustiloxin H (PubMed:27166860).  Finally, carboxylative dehydration performed by the cysteine desulfurase-like protein ustD yields ustiloxin B (PubMed:27166860).
What are the official names of this protein?
Pyridoxamine 5'-phosphate oxidase family protein ustO, Ustiloxin B biosynthesis protein O.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: URK_BORBZ
Sequence: MAKIIGISGGSGSGKTTVVSKISEFIPEFVLISQDNYYKSVGDYEHEFSKVNFDHPDAFDNNLFYEHLKNLKKNSPIDMPLYDFINHKRQLKTVLVVPTPVVIVEGIMIFVEERVRNLIDLKIYIDTPNDIRFIRRLRRDISKRGRTVESVIDQYLNTTRWGYYRFIEPTKEYADLIIPEGGHNDKALYVLSTFLKSLSKEGLDFT
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB_ARCGA
Sequence: VHLTADEKAAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFDSFGDLSSPDAVMGNPKVKAHGKKVLNSFSDGLKNLDNLKGTFAKLSELHCDKLHVDPENFKLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: HSPB6_RAT
Sequence: MEIRVPVQPSWLRRASAPLPGFSTPGRLFDQRFGEGLLEAELASLCPAAIAPYYLRAPSVALPTAQVPTDPGYFSVLLDVKHFSPEEISVKVVGDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQASLPSPPAAK
What is the function of this protein?
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (By similarity).  Seems to have versatile functions in various biological processes (By similarity).  Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility (By similarity).  May regulate myocardial angiogenesis implicating KDR (By similarity).  Overexpression mediates cardioprotection and angiogenesis after induced damage (PubMed:15105294).  Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity (By similarity).
What are the official names of this protein?
Heat shock protein beta-6, HspB6, Heat shock 20 kDa-like protein p20, Hsp20.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Note=Translocates to nuclear foci during heat shock.
Protein: KCY_SHEB5
Sequence: MSERAPVVTIDGPSGAGKGTISQLLAQHLGWQLLDSGAIYRVLALAAIHHNVELENEESITLLAAHLDVKFLTGNDTDPVQVILEGEDVTTDIRTQECSNAASKVAAFPRVREALLRRQRAFKTAPGLIADGRDMGTVVFPSAPAKLYLTASAEERAQRRYNQLQDKGFDVNIERLLSEIIERDDRDMNRPVAPLVPAEDALIIDTSGKGIDEVLALALNFINQKLSDTN
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTDB_ECO57
Sequence: MKKILTTPIKAEDLQDIHVGDVIYLTGTLVTCRDVCHRRLIELKRPLPYDLNGKAIFHAGPIVRKNGDKWEMVSVGPTTSMRMESFEREFIEQTGVKLVVGKGGMGPLTEEGCQKFKALHVIFPAGCAVLAATQVEEIEEVHWTELGMPESLWVCRVKEFGPLIVSIDTHGNNLIAENKKLFAERRDPIVEEICEHVHYIK
What are the official names of this protein?
L(+)-tartrate dehydratase subunit beta, L-TTD beta.
What is the protein family that this protein belongs to?
Belongs to the class-I fumarase family.
Protein: CHEV1_HELPY
Sequence: MADSLAGIDQVTSLHKNNELQLLCFRLGKNKDLYAVNVFKIREVVKYHGNLTIISHENNSLVEGLIIIRELTIPLIDMKKWFYYDSQNKNKDLRPYRIEKEKGEDDIVMICEFSRWTIGVRIYEADRILSKKWTEMEQSAGLGGSAGNNKLVSRTRYFDGRLVQVVDIEKMLIDVFPWIEDEKHNDLETLSKIHSNQCVLLADDSPSVLKTMQMILDKLGVKHIDFINGKTLLEHLFNPTTDVSNIGLIITDLEMPEASGFEVIKQVKNNPLTSKIPIVVNSSMSGSSNEDMARSLKADDFISKSNPKDIQRVVKQFLELA
What is the function of this protein?
Plays an essential role in chemotaxis signal transduction system in order to colonize the host stomach.  May act as a phosphate sink to control the flow of phosphate to CheAY.
What are the official names of this protein?
Chemotaxis protein CheV1.
Protein: Y505_PASMU
Sequence: MKVLFSYGTYNNRPYKACGVYESDNRENDGVITDYLSTIPDSYADNGFKVLAAVKDPTITREWIDSQAFEALIEHDQIKVGFYLLDDMEEEDIPDDVDERDTDPRFIPRKEFAYLLEKWLDFYHRPITDMNYQEIIDTKDAY
What are the official names of this protein?
UPF0275 protein PM0505.
What is the protein family that this protein belongs to?
Belongs to the UPF0275 family.
Protein: MSCL_BACP2
Sequence: MLKEFREFAVKGNVIDLAVGVIIGGAFGKIVTSLVNDLIMPLVGIIIGGHDFSGLSIKIGSAQILYGSFIQTVIDFLIISFSIFIFIRYLNKLKRKKVEEEEVVETPDQTEVLLTEIRDLLKHQSQSKDVQ
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NFUA_SHEB9
Sequence: MITISDAAQAHFVKLLADQPEGTHIRVFVISPGTSQAECGVSYCPPDAVESDDIEIEFTGFNAMVDEKSAPFLEDATIDFVTDQLGSQLTLKAPNAKMRKVSGDAPLVERIEYVIQSEINPQLAGHGGNIMLVEITKEGVAVLQFGGGCNGCSQVDITLKDGIEKQLLDMFPGELTGVRDVTDHQHGEHSYA
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: GLYA_CAMJD
Sequence: MSLEMFDKEIFDLTNKELERQCEGLEMIASENFTLPEVMEVMGSILTNKYAEGYPGKRYYGGCEFVDEIETLAIERCKKLFNCKFANVQPNSGSQANQGVYAALINPGDKILGMDLTHGGHLTHGAKVSSSGKMYESCFYGVELDGRIDYEKVREIAKKEKPKLIVCGASAYARVIDFAKFREIADEVGAYLFADIAHIAGLVVAGEHPSPFPHAHVVSSTTHKTLRGPRGGIIMTNDEQLAKKINSAIFPGIQGGPLMHVIAAKAVGFKFNLSDEWKVYAKQVRTNAQVLTNVLMDRKFKLVSDGTDNHLVLMSFLDREFSGKDADLALGNAGITANKNTVPGETRSPFITSGLRLGTPALTARGFKEKEMEIVSNYIADILDDINNEKLQENIKQELKKLASNFIIYERAMF
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_CITK8
Sequence: MAHIEKQAGELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMINVALNNGTLQHPVKGVHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVHNVLAKAYGSTNPINVVRATIDGLENMNSPEMVAAKRGKSVEEILGK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: APAH_PECAS
Sequence: MSTYLVGDVHGCLVELKALLAQVSFNPEQDTLWLTGDLVARGPDSLQVLRFVRSLGSSVRMVLGNHDLHLLAVYAGISRNKPKDRLNDLLTAPDADELINWLRRQPILQVDEDLKLVMAHAGITPQWDLPTALVCAREVESILSSDSYPLFLDAMYGDMPNHWSPELSGLARLRFSTNVFTRMRYCFSGGQLDMLCKEQPGQAPSLLKPWFDLPSQVAGEYAIAFGHWASLEGKGTPENIYALDTGCCWGGELTMLRWDDKRYFTQPSLSSNTELSGDITL
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: ATPG_PEDPA
Sequence: MAISEQDVKRRIDSTKKTSQITTAMQMVSTAKLSQIQRHTVGYQVYAQKVESIVAHLAKSHLMSASVAGKAKSDQAISAADLLAQRPVKKTGYLIITSDRGLVGSYNSSVIKQTNDFMQKHGHTEGDAVILAVGGTGSDFYRNRNHEVAYEYRGVSDVPTFNEIREIVKTVTKMYTEEKFDELYVCYNHFVNRLSNSFRVTKLLPIGGDDLANNEAHEQVTAEYDTEPSPEALLQEILPQYAESLVYGAILDAKTAEHAASSSAMRSASDNASDLIADLELQYNRARQSAITTEITEITGGQAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: METAA_THEXX
Sequence: MPIKVPNDLPAATVLEEENLFVMRQDRADTQDIRPLEIIVLNLMPTKVETEIQIMRLLSNTPLQINVTLLQMSTHVSKNISQEYLDKFYATFDEVKDRKWDGLIITGAPVENIDFSEVDYWDELCEIMDWSVKNVFSTMHICWGAQAGLYHHYGVDKYPLEEKMSGVFPHRALVGDDPLLRGCDDVFWFPHSRHTEVRARDILKNPHLHIIAVSDEAGVGIVISEKANQVFITGHMEYDAKTLSYEYYRDLGRGMNPHVPYHYFPDDDPSRDPLMTWRSTANLIFGNWLNYYIYQNTPFDLNDVGKE
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDEA_ECOLI
Sequence: MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM
What is the function of this protein?
Required for optimal acid stress protection.  Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins.  Important for survival of enteric bacteria in the acidic environment of the host stomach.  Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs.  May cooperate with other periplasmic chaperones such as DegP and SurA.
What are the official names of this protein?
Acid stress chaperone HdeA, 10K-S protein.
What is the protein family that this protein belongs to?
Belongs to the HdeA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PSBF_CAPAN
Sequence: SISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: EFCC1_MOUSE
Sequence: MESSAGDPYRRPARRTQWLLSALAHHYGLDRGVENEIVVLATGLDQYLQEVFHHLDCRGAGRLPRADFRALCAVLGLNADGETATEDANSAEAASTNPAAGMIAGGDADVREEARLALRADPPELTFRQFHARLCGYFSSRAGPRLPRGALSEHIETQIRLRRPRRRRRPGSPSLHGGAYGERVAHLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQSDIPEAAAHELQRAQGALAEAEARARRLQRGQVEVRLRTEEARQAVRRSLHRVRELEALARRVPCLQRQVQRLEAELRGYRSEGPQLLTPQQASPRPGNRNGEPTAGGTRDSDTTPEGVQRSDSRDTDEEDEQLFRSVEGQAASEEEEEERWQEKPGRPQAHGEVPLVQPSGCVSRCDDQTAETLKASFGHCDGAEHICTLELETHVTRLGEQLQTLGTPEEEAELQQMVEAEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKMLLNALDRNPSQEGTCGTLAILDTLHQALVGCELLQRNPSAPASTAPAHTNPFLISC
What are the official names of this protein?
EF-hand and coiled-coil domain-containing protein 1, Coiled-coil domain-containing protein 48.
Protein: NUDC1_XENLA
Sequence: MEGANCSLKVNRHLLDPKFESYKLSLDPLPCYNVELDAAVAEVTLRDDQYTLDHMRAFGMYNYLHCNPWLPNSVFYIDQLKRVMSFTVTLDTAMGKPIEVFRFPRDLNACDNRLCSSMHFASAQWVTLSDGTGTLYIIRIGNQSDSLSGKWEIMFNQELGEPFIVVHSISSVRDELHVIDVLLLSVEKDESDIEGSGFHVCLEWVSAARAQNQENGEYEILKRRKLFGKSVPHYAAIEPLGNGVMMISYKPFRFIANEKDPHEPSEDEKMDEDNKREPLYNWQQTGEEVTLTFLLPEGKTKEDLNIKFLPGEIDISIKDQGTFLKGQLYSDVDCESSAWIMKEGRGVEVTLTKREPGCTWAELVIADKQGEYIADPAQTAAIAEKLMHLTSEDINPNPESEKPPCNAQELEECDIFLEDSTNLCRFDGTHLKATHVVNLGSNPYLFTFVATPELMPCFALRHDVDALLWQPVSEQPDNLWEHIATFNALGYVQASKQDKKFFTCAPNFSYSALCECVRRIFIYRQPTPVSTELYNRKEGRRVGQVAKQQVASLETTDPILGFQASNERLFVLTTKTLSVIKVNSTA
What are the official names of this protein?
NudC domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: REP_MYMVV
Sequence: MPRLGRFAINAKNYFLTYPRCPLTKEDVLEQLLALSTPVNKKFIRVCRELHEDGEPHLHVLLQFEGKLQTKNERFFDLVSPTRSTHYHPNIQAAKSASDVKSYMDKDGDVLDHGSFQVDGRSARGGKQSANDAYAEALNSGSKLQALNILREKAPKDYILQFHNLNCNLSRIFADDVPPYVSPYSLSAFDKVPSYISSWASENVRDSCAPERPISIVIEGDSRTGKTMWARALGPHNYLCGHLDLNSKIYSNDAWYNVIDDVDPHYLKHFKEFMGAQRDWQSNVKYGKPTHIKGGIPTIFLCNPGPKSSYKEYLDEPDNTALKLWASKNAEFYTLKEPLFSSVDQGATQGCQEASNSTLSN
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep binds a specific region at the genome origin of replication.  It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.
What are the official names of this protein?
Replication-associated protein, Rep, Protein AC1, Protein AL1.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: SSRP_NITSB
Sequence: MKVIATNKKAFHDFEILERYEAGLVLQGSEVKAIRAGRVNLKDSFVKFVKGEPFVFGMHISYLDSANPHFRPDEKRPRKLLLHKKEIDKLIGKTSEKGYTIVPLKLYFNKKNIAKLEIGLAKGKTLHDKRESLKKKIMDREARAAMKEYR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RPO1C_SACSH
Sequence: MENVIDEKDKSYLEEKVKQASNILPQKIVEDLKNLISNKEVLVTRDEIDKIFDLAIKEYSEGLIAPGEAIGIVAAQSVGEPGTQMTLRTFHFAGIRELNVTLGLPRLIEIVDAKKVPSTPMMTIYLTDEYKHDKEKALEVARKLEYTKIENVVSSTSIDIASMSIILQLDNEMLKDKGVTVDDVKKAINRLKLGEFVIDESEGNTLNISFANIDSIAALFKLRDKILNTKIKGIKGIKRAIVQKKGDEYIILTDGSNLSGVLSVKGVDIAKVETNNIREIEEVFGIEAAREIIIREISKVLAEQGLDVDMRHILLVADVMTRTGVVRQIGRHGVTGEKNSVLARAAFEVTVKHLLDAAARGDVEEFKGVVENIIIGHPIKLGTGMVELTMRPILR
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_PARL1
Sequence: MTDRIVGAAKREEDELERSLRPQVLSDFVGQARARENLAVFIEAARTRAEALDHVLFAGPPGLGKTTLAQIVARELGVNFRATSGPVISKAGDLAALLTNLEPRDVLFIDEIHRLSPAVEEILYPAMEDFQLDLIIGEGPGARSVRIELAPFTLIGATTRTGLLTTPLRDRFGIPVRLHFYEVAELEGIVRRGASVLGVAMTPDGAHEIARRARGTPRVAGRLLRRVRDFASVEGVKSIDAKAADKALQRLEVDELGLDALDHRYLRCIAVSFSGGPVGVETIAASLSEPRDAIEEIIEPYLIQQGLVNRTPRGRTLTPAAFAHIGVALPAGRSGEPGQARLFDGDEENGSA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MENE_STAA3
Sequence: MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRLTPNEMTNQMKSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNSLLDNTMGIQYETSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQILTMIKNERITHISLVPQTLNWLMQQGLHEPYNLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPEMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNVYLYPTDLTGTFENGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKVPKHFEKVDTLPYTSTGKLQRNKLYRG
What is the function of this protein?
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
What are the official names of this protein?
2-succinylbenzoate--CoA ligase, o-succinylbenzoyl-CoA synthetase, OSB-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.