PharMolix/UniProtQA huggingface dataset:
Protein: GALT_HALH5
Sequence: MSQSSIAIQIEALLTYALQHGLITKWDIDASRNRVLDVLDLDELEPVEQVDVECEMPYPILENILDWAAENGRLEANTVTYRDLLDTKLMGALLGQPSETIRTFYERYEQQGPEEATKVFYDFSKQVHYIRTDRIAKNEHWFSETPYGQLEITINLSKPEKDPKAIAQAKHLQASSYPKCLLCKENVGYRGRVNHPARQNLRVIPVELNQEQWYMQFSPYVYYNEHAIVFSGEHVPMKISTETFARLLEFTEKFPHYFIGSNADLPIVGGSILSHDHFQGGNHAFPMAKASMEKTFSISRFPSVIAGIVKWPMSVVRLQGMDRSELVKAADHVYHAWQAYGDEAADIYPFTGDTPHNTITPIARRRGELFELDLVLRNNRTSKEHPDGIFHPHQEVHHIKKENIGLIEVMGLAVLPGRLKEELELLAEALLSSDPRQVIARYEQIQKHEAWALAIKERHAHLHDSNVMDILRDEIGKVFATILAHAGVFKRTGEGAAAFDRFISTLNQ
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
Protein: MATK_GALBE
Sequence: MEELQGYLEIDRSRQQHFLYPLLFQEYIYALAHDHGLNGSIFYEPMENLGYDNKSSSLIAKRLITRMHQQNHLIISISVNDSKQNRFVGHNKNLYSQMVSEGFAVIVEIPFSLRLVSSLEEKEIEKSHNLRSIHSIFPFFEDKLSHLNHVSDILIPHPIHLEILVQTLRCWVQDAPSLHLLRFFLHEYGNSNSLITPKKSISFFSKENQRFFLFLYNSHVYECESVFVFLRKPFSHLRSTSFGAFLERIHFYGKTEHLVVVPRNYFQKTLWLFKDPFMHYARYQGKSILASKGTHLLMKKWKSHLVHFWQYHFYLWSQPDRIHINQLCNHSFYFLGYFSSVRLNLSVVRSEMLENSFLIDTSIKKFETLAPIIPLIGSLAKAKFCNVSGHPISKSVWANSSDSDILNRFGRIYRNLSHYHSGSSKKQILYRIKYILRLSCARTLARKHKSTVRTFLKRLGSEFLEEFLTEEEQVLSLIFPRTSFPFYRSHRERIWYLDIIRINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GSTZ2_DIACA
Sequence: MSSSETQKMQLYSYSSSSCAWRVRIALHLKGLDFEYKAVDLLKGEHLTPEFLKLNPLGYVPALVHGDIVIADSLAIIMYLEEKFPENPLLPRDLQKRALNYQAANIVASNIQPFQNLAVLNYIEEKLGSDEKLSWANHHIKKGFS
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 2, GST class-zeta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Zeta family.
Protein: PSI1_SCHPO
Sequence: MVADTKLYDCLEVRPEASEAELKKAYRKLALKYHPDKNPNGEKKFKEISLAYEVLSDPQRRKLYDQYGITEGNAAPPPPGAEGGPGAGFGGFPGAGPGGARTFHFNMGGPGGAQFFSASDPNDIFERVFGHAFAGGGGMGGGMGGMGGMDDDMDMDGGFGTRTRGGGMPGGFANMFGGGGAGPHARRSHPSFGGSRPSQPPAQNEVITRPLNVSLEDLFTGCTKKMKISRHIIDASGQSVKADRILEIKVKPGWKAGTKIKFAGEGDEKPDGTVQDIQFVLAEKPHPVFTRSGDDLRMQVELSLKEALLGFSKQISTIDGKKLKVSSSLPTQPGYEITYPGFGMPLPKNPSQRGNMIIECKVKFPTELTPAQKTAAEAF
What is the function of this protein?
Required for nuclear migration during mitosis.  It is required for the normal initiation of translation.
What are the official names of this protein?
Protein psi1, Protein psi.
Protein: NUOK_BUCCC
Sequence: MLSLNYGFTISIILFFIGIISLLIHKNLIFILVSLEVLINSIILGFILIGKYWKQIDCCVLYIFIVTIATVEVSVMLAIFLRIYQRYHTLDIYKLREISK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACPS_LEPBP
Sequence: MLSVGNDIVENERIRELLQKHGDRFLKRVFTDDEVEYCHKHKDPVPFLAGRFACKEAVIKALNLEPGQVADMREIELAGTNFGKKTLVIHGKTEKFFREKGFTGSSVSISHADHYSTAVVVFFKEPK
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBPE_NOSS1
Sequence: MSIYVGNLSYSVTQDDLTKVFSEYGSVTRVQLPTDRETGRVRGFGFVEMESSAAEDAAIQALDGAEWMGRVLKVNKARPREEKGARSGGGSWSRNNGGY
What are the official names of this protein?
Putative RNA-binding protein RbpE.
Protein: ATPB_MYCUA
Sequence: MTVTAEKTDKSASSETSGRVVRVTGPVVDVEFPRGSVPELFNALHAKIDFGSLAKTLTLEVAQHLGDSLVRTISLQPTDGLVRGTEVTDTGRPISVPVGESVKGHVFNALGDCLDEPGYGEDFEHWSIHRKPPAFEDLEPRTEMLETGLKVVDLLTPYVRGGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELQEANVLKDTALVFGQMDEPPGTRMRVALSALTMAEWFRDEAGQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDATTELSRAVFSKGIFPAVDPLASSSTILDPGVVGDEHYRVAQEVIRILQRYKDLQDIIAILGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIEAFDRLCKGEFDHVPEQAFFLIGGLDDLAKKAESLGAKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DXS_METPP
Sequence: MKSYPLLSTIDQPADLRGLSRAELKQLAQELRDHVLTSVSQTGGHLSSNLGTVELTIALHHVFNTPQDRLVWDVGHQTYPHKILTGRRDRMAGLRQLGGISGFPRRDESEYDTFGTAHSSTSISAALGMALAAKIKGEDRRSVAIIGDGAMTAGMAFEALNNAGVSGANMLVVLNDNDMSISPPVGALNRYFARLMSGRFYSAARQGAKSVLKNAPPLLELARRFEEHAKGMIVPSTIFEEFGFTYVGPIDGHDLDSLIPTLENLRDRKGPQFLHVVTKKGYGYKLAEADPVAYHGPGKFNPAEGLKKAAPGKPSFTQVFGQWLCDMAAKDTRLVGITPAMREGSGMVEFEQRFPDRYFDVGIAEQHAVTFAAGLACEGLKPVVAIYSTFLQRGYDQLIHDVAIQNLPVVFALDRAGIVGADGATHAGAYDIAYVRCVPHLSLIAPADENECRQALTAAFEQQHPVAVRYPRGAGVGVAVQSELTALPWGRGELRREARGGGRRIAILAFGTLLYPALAAAEKLDATVANMRFIKPLDTELVLSLARSHEALVTVEEGCLQGGAGSAVLEALQAAGVNLPVLTLGLPDEFVEHGDPAKLLAQLGLDAAGIEQSILKRFGAKLELVRPAING
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: RL11_THEFY
Sequence: MPPKKKLAAVVKVQLPAGQATPAPPVGTALGPHGVNIMEFCKQYNAATESQRGNIIPVEISIYEDRSFSFVTKTPPAPALILKAAGLEKGASTPSRSVAGSITRDQVREIAQTKLPDLNTTSLEAAEKIIAGTARSMGIEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: MATRX_NDVB
Sequence: MDSSRTIGLYFDSAHSSSNLLAFPIVLQDTGDGKKQIAPQYRIQRLDSWTDSKEDSVFITTYGFIFQVGNEEATVGMINDNPKRELLSAAMLCLGSVPNTGDLVELARACLTMVVTCKKSATNTERMVFSVVQAPQVLQSCRVVANKYSSVNAVKHVKAPEKIPGSGTLEYKVNFVSLTVVPKKDVYKIPTAVLKVSGSSLYNLALNVTINVEVDSRSPLVKSLSKSDSGYYANLFLHIGLMTTVDRRGKKVTFDKLEKKIRSLDLSVGLSDVLGPSVLVKARGARTKLLAPFFSSSGTACYPIANASPQVAKILWSQTACLRSVKIIIQAGTQRTVAVTADHEVTSTKLEKGHTLAKYNPFKK
What is the function of this protein?
The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus/respirovirus/rubulavirus M protein family.
What are the subcellular locations of this protein?
Virion.
Protein: HSLV_ANADE
Sequence: MRPMHGTTVLCVRREGRVVIAGDGQVTLDKTVMKATARKVRRLGEGQVVAGFAGATADAFQLFELFEKKLKEHARSLPRAAVELAKQWRTDRMLRRLEALLVVADREHVLVLSGAGDVIEPDPVANGAAVAIGSGGPYALAAARALLAHSSLDARRVAEEAMKLAAEICIYTNGNLTIEEL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSZ_SYNY3
Sequence: MTLNNDLPLNNIGFTGSGLNDGTEGLDDLFSSSIVDNEPLEALVETPTFASPSPNLKRDQIVPSNIAKIKVIGVGGGGCNAVNRMIASGVTGIDFWAINTDSQALTNTNAPDCIQIGQKLTRGLGAGGNPAIGQKAAEESRDEIARSLEGTDLVFITAGMGGGTGTGAAPIVAEVAKEMGCLTVGIVTRPFTFEGRRRAKQAEEGINALQSRVDTLIVIPNNQLLSVIPAETPLQEAFRVADDILRQGVQGISDIIIIPGLVNVDFADVRAVMADAGSALMGIGVGSGKSRAKEAATAAISSPLLESSIQGAKGVVFNVTGGTDLTLHEVNVAAEIIYEVVDADANIIFGAVIDDRLQGEMRITVIATGFNGEKEKPQAKTSSKPVLSGPPAGVETVPSTTTPEDPLGEIPMAPELDIPDFLQKRRFPRR
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: PRVB2_MERAP
Sequence: AFSGILAEADIAAALKACEAADSFNYKAFFAKVGLSAKSADDIKKAFFVIDQDKSGFIEEDELKLFLQVFSAGARALTDAETKAFLKAGDSDGDGAIGVDEFAVLVKA
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin beta 2.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: RSMA_CAMHC
Sequence: MYIAKKKFGQNFLKDKNALNKIIESIPENAENIVEIGAGLGDLTYELLRKFKVKSYEIDKDLIEFLKSKFACELENRKFELVFGDALKFWKNGLCNKNYFLVANLPYYVATNMILKAIDDELCDGFVAMVQKEVAEKFCAESGDSEFGGISVLADIFGKCEFLFSVPADSFEPAPKVVSAVIRLKKTRKIDDIFENSVQYENFKNFLKICFSSPRKTIMKNLSTKFDKEILQSIFEKLDLTTNLRAHELNFTLFFKIFKNLRIRDERNK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSB_BUCAP
Sequence: MASRGVNKVILIGHLGQDPEVRYMPNGNAVVNMTLATSENWKDKNTGENKEKTEWHRIVLFGKLAEIAGEYLRKGSQVYIEGSLQTRKWQDQNGLERYTTEVIVNIGGTMQMLGNRNSNSHNVTLNENNNIVKTKKIEINNSPKKIEKIDSSEIDFDDEIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: SYM_BAUCH
Sequence: MIQVASKILVTCALPYANGSLHLGHMLEHIQADIWVRYQRIRGKQVYFICADDAHGTPIMLKAKQSGITPEAMINKINQEHQTDLAQFEISYDNYYSTHSDENRELVISIYNTLKENGLIKKRMISQLYDPIHNIFLPDRFVKGYCPRCKLPDQYGDNCEICGATYHPTDLIDPKSTLSGVTPVISKSKHLFFDLPVFSEVLRAWTRSGALQEQVANKMQEWFDMGLQQWDISRDAPYFGFEVPDTPGKYFYVWLDAPIGYIGAFKNLCNKRNDIIFDEFWHLSSKADLYHFIGKDITYFHGIFWPAILEGSKLRKPTNLFVHGYVTINGAKMSKSRGTLIKASTYLAHLDASYLRYYYATKLSSDINDIDLNFNDFVNRVNADIINKVINLAARNASFIQKYFDNKLSATIEDQYLYDYFVTASVSIGEAFNNRETSRAIREIMILADRANVYIHKKEPWVVAKNKYYQQDLHNICSMGINLFRLLMTYLQPVLPNLAIQAEAFLNTKLNWDSMVIPLTNHKISPFKTLLQRITLSQVKAMIDATH
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_BURA4
Sequence: MTVKLTIDCMGGDHGPSVTVPAAVKFVRAHPDAHLMLVGIESAIRAQLKKLKALDDPALTIVPATEVVAMDDPVEVALRKKKDSSMRVALNQVKEGAAQACISAGNTGALMAVSRYVLKTLPGIERPAIAFALPNPTGYTMMLDLGANVDCEPQHLLQFAEMGHALVAALEGKERPTIGLLNIGEEVIKGNETIKRAGELLRASTLNFRGNVEGNDIYKGTVDVIVCDGFVGNVALKTSEGLAQMLSDIIREEFGRSLMSKLMALLALPVLMRFKKRVDHRQYNGAALLGLKGLVIKSHGSADAYAFEWAIKRGYDAVKNGVLERLARAMADNSVSLGDGGHDAGGAGTASPAPGHHAEPSAAQSSKA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ATPA_ACTP7
Sequence: MQLNSTEISELIKKRIAQFDVVSEAQSTGTIVSVSDGIIRIHGLADVMQGEMIELPGNRYAIALNLERDSVGAVVMGPYADLAEGMSVKCTGRILEVPVGRGLLGRVVNTLGQPIDGKGEIDNDGFSPVEVIAPGVIDRQSVDQPVQTGYKAVDSMVPIGRGQRELIIGDRQTGKTALAIDAIIAQKDSGIKCIYVAIGQKASTIANVVRKLEEHGALANTIVVVASASESAALQYLAPYSGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERAARVSADYVESFTNGAVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESSLFNSGIRPAVNPGISVSRVGSAAQTKAIKKLSGGIRTALAQYRELAAFAQFASDLDDATRKQLSHGQKVTELLKQKQFAPMPVSEQALVLFAAEFGYLDDVELERIGSFESALLAYANSNHTDFMKNLAKSGDYNDSIKDQLKAIVEDFKKNGAW
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: WTR6_ARATH
Sequence: MKSVVAMVAVQFIFAGMFILFKITVDDGTNLKVLVAYRLSFATIFMLPLALIFQRKKRPEFTWRLLLLAFVSGLLGAAIPNILYLPGMARTSATFSAASSIISPLITLVLGLVFRMETLRLGSNEGRAKLVGTLLGACGALVFVFYKGIEIHIWSTHVDLLKGSHTGRATTNHHVSILGVLMVLGSNVSTSLWLLLQAKIGKELGGLYWNTSLMNGVGSLVCVIIALCSDHDWEQWQLGWDINLLATLYSGIVVSGMVVPLVAWCIATKGPLFVTVFSPIRLVIVALIGSFALEEPLHLGSIIGAMIMVGGVYLVVWCKMKEKKSASTTSDHIETNKNNKELDLGNLSSVNRDVP
What are the official names of this protein?
WAT1-related protein At1g25270.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GT1_BEAB2
Sequence: MSPSRSEPLIDNLVDRSNLKIVALASPADGHTFPLLRIVEELVLRGYDVTFLASEDYRARTAAVGAYFVPVPPYDDIQRITTELSVIADPGERMNAAMIELFITPTAGRMATLYAALEDVKREKPLHKVVLLTESFFLGDHPLFLGAPLPKGFTRRPRAINIHACSYGLSSVDSAPFGLTIIPDGTAESREKYRKLHSDMLTGSLAESVALQKKVLTELGATNMDEVEGRNPLDVIATTADVTLQMCPPSLEYRRSDIHPKVRFIGALPPRAPPKTFSAPPFWNTVINGSKRVVVVSQGTVAVRYDQLLVPAMHALADRDDIVVVAILGQKGAELPGEVAIPSNAYTVDYLSYDAMLPYASVFVLNAGYGGFMHGIVNGVPMVLAGGSEDKPEVANRGEFAGVGINLRTGTPSQRQIRQGVDEILSNPKYKRRVKEIQLENEKMKAMDSVEKEILKWAAMD
What is the function of this protein?
UDP-glucosyltransferase; part of the pathway that mediates the biosynthesis of tenellin-type 2-pyridones, iron-chelating compounds involved in iron stress tolerance, competition with the natural competitor fungus Metarhizium robertsii and insect hosts infection (PubMed:34903054).  Targets the N-OH hydroxyl residue of 15-hydroxytellenin (15-HT) to produce pyridovericin-N-O-(beta-D-glucopyranoside) which is further methylated by the methyltransferase MT1 to yield pyridovericin-N-O-(4-O-methyl-beta-D-glucopyranoside) (PMGP) (PubMed:34903054).  The pathway begins with the assembly of the polyketide-amino acid backbone by the hybrid PKS-NRPS tenS with the help of the enoyl reductase tenC.  These enzymes catalyze the synthesis of the pyrrolidine-2-dione intermediates pretellinin A, 11-hydropretellenin A, 12-hydropretellenin A, 13-hydropretellenin A, 14-hydropretellenin A, 12-oxopretellenin A and prototellinin D.  The cytochrome P450 monooxygenase tenA then catalyzes an oxidative ring expansion of pretenellin A and 14-hydropretellenin A to form the 2-pyridone core, leading to pretenellin B and pyridovericin, respectively.  The cytochrome P450 monooxygenase tenB is then required for the selective N-hydroxylation of the 2-pyridone nitrogen of yield tellinin and 15-hydroxytellenin (15-HT), respectively.  The UDP-glucosyltransferase GT1 and the methyltransferase MT1, located outside the tenS gene cluster, contribute to the stepwise glycosylation and methylation of 15-HT to obtain the glycoside pyridovericin-N-O-(4-O-methyl-beta-D-glucopyranoside) (PMGP).  Additional related compounds such as 1-O-methyl-15-HT, (8Z)-1-O-methyl-15-HT, and O-methyltenellin A are also produced but the enzymes involved in their biosynthesis have still to be determined (PubMed:34903054).
What are the official names of this protein?
UDP-glucosyltransferase 1, GT1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: RNY_ENTFA
Sequence: MVLNILLAIVGLIVGLGLGFVIAKSRHDKAINGAKISASSILENARKESETLKKEALLEAKEENQKYRSEIESELKESRLELKSQENRLIQREQTLDRKDDSLEKREGSLEEKEEKLGARQQLIDEREKEVENLINQQHQELERIASLSKEEAKSIIMKSTEEELNHELTLMVKESEQRAKEESDRKAKNLLSLAIQRCAADSVSETTVSVVTLPNDEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVVLSGFDPIRREIARMTLEKLIQDGRIHPARIEEMVEKSRKEMDERIREYGEQAAFEVGAHTLHPDLIKILGRLRFRTSYGQNVLNHSIEVAKLAGVLAAELGEDVQLAKRAGLLHDIGKALDHEIEGSHVEIGAELAAKYKENSVVINAIASHHGDVEATSVISVLVAAADALSAARPGARSESLENYIRRLENLENISNSFEGVDSSFAVQAGREVRVMVKPEEISDLESVRLVRDIRKKIEDDLDYPGHIKVTVIRETRAVDYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: UQCC6_HUMAN
Sequence: MPAGVPMSTYLKMFAASLLAMCAGAEVVHRYYRPDLTIPEIPPKRGELKTELLGLKERKHKPQVSQQEELK
What is the function of this protein?
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263).  Mediates early complex III biogenesis (By similarity).  Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity).  Also required for cytochrome c oxidase complex (complex IV) assembly (PubMed:34969438).
What are the official names of this protein?
Ubiquinol-cytochrome-c reductase complex assembly factor 6, Protein BRAWNIN.
What is the protein family that this protein belongs to?
Belongs to the UQCC6 family.
Protein: NTPPB_VIBVU
Sequence: MENYQLVLASTSPFRQQLLEKLAIPFSTLSPNCDETPLEGESPQQLVLRLAESKAQSCQINQPSLVIGSDQVCVINGNIVGKPHNRQNAIAQLTAQSGQSIVFYTGLAVYNSETGETRSCIDEFKVHFRPLTQAQIVRYVDKEQPFYCAGSFKSEGLGIALFEKLEGKDPNTLVGLPLIDLIDLLAQQGMQVLG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMB_YERPN
Sequence: MKNTYNLRSIAAKAISQVLDQGQSLSAVLPELQKNISDKDRALLQELCFGTLRVLPQLEWCIQQLMARPMTGKQRVFHYLIMVGLYQLIYTRIPPHAALAETVEGATVLKRPQLKGLINGVLRQFQRQQVELLERAVNNDSHYLHPSWLLARIKQAYPAQWQQILDANNQRPPMWLRVNRLHHSRSEYLELLTQADINAEPHPIYRDAVRLITPCAVNHLPGFELGWVTVQDASAQGCVDLLDPQNGEQILDLCAAPGGKTTHILEAAPKAHVLAVDIDEQRLSRVKENLQRLQLQAVVRVGDGRAPDTWCGDQQFDRILLDAPCSATGVIRRHPDIKWLRRDRDISELAQLQSEIIEAIWPKLKHGGVLVYATCSILPEENQQQIAAFLQRHPEAQLTETGTTAAPGKQNLPHPEDGDGFFYAKIIKK
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YXKD_BACSU
Sequence: MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILYYLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDELIINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSSYFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGVTILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDISK
What are the official names of this protein?
UPF0750 membrane protein YxkD.
What is the protein family that this protein belongs to?
Belongs to the UPF0750 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEUD_SHEB5
Sequence: MQPFTTHTGLAVMIDSTNIDTDQIIPKQFLSKVTRDGFGVHLFHDWRYLDDAGDQPNPEFSLNQSRYRGASILLAQENFGCGSSREHAPWALADFGLRAIIAQSFADIFYGNSINNGLLPVALTHAQVRQLMDEVAAEAGAQITVDLTSCKVVSPSGAEFSFTLAESARHKLLNGLDAIGLTLSHAAQIGQYETQIQGWRR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RL17_OENOB
Sequence: MGYRKLQRTKSQRKALLRDLTTNLILNGKIQTTEARAKEVRRQAEKMITLGKRGDLAARRLAATYLRDVEDENKIKNATNAEDIVEQKAVKTLFSDVAPRFKSRNGGYTRIYKLGQRRGDAAPMALLEFVD
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RK36_CHLAT
Sequence: MKVRASVRKICEDCRLIRRRGRLMVICSNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MLIC_PSEAE
Sequence: MKKALWLLLAAVPVVLVACGGSDDDKQTAQVDYLALPGDAKLDTRSVDYKCENGRKFTVQYLNKGDNSLAVVPVSDNSTLVFSNVISASGAKYAAGQYIWWTKGEEATLYGDWKGGEPTDGVACKER
What is the function of this protein?
Specifically inhibits C-type lysozymes.
What are the official names of this protein?
Membrane-bound lysozyme inhibitor of C-type lysozyme.
What is the protein family that this protein belongs to?
Belongs to the MliC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Note=Anchored to the periplasmic side.