PharMolix/UniProtQA huggingface dataset:
Protein: TTCA_HISS2
Sequence: MSLNIITEKDKKQSYNLNKLQKRLRRNVGNAIADFNMIENGDKVMVCLSGGKDSYTLLDILLNLRLNAPIHFDIVAVNLDQKQPGFPEHILPEYLKSISVDYKIVAENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDMLETLFLNMFYGGKLKSMPPKLISDDGKQIVIRPLAYCKEKDIEKYAVAKQFPIIPCNLCGSQPNLQRQVVKEMLQKWDRQYPGRIETMFSAIQNIVPSHLCDSNLFDFKRIRHGKIPEGIEGDIAFDKEAFSPTPLVQENDEKIDFIQGEMISFKEVN
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GIP1_GIBZE
Sequence: MLTSPRLILLLLAWVFSALVASALVKKDWTITWEPGAPNGQERNMIKINNQFPGPTILCDEDDDIEVTVHNKMPFNTTVHWHGLERVNCVRMMGTPWSDGTPGMSQKPIEMGQSFIYRFKASPAGTHWYHSHSRATVLDGLYGPIFIRRKPDAPAPWHLISKEQADIDAMSRAVIDPKLVMVSDWTRFMSWEYMAAEESSGMAIFCSDSILVNGKGSLYCPDVDVLINHTSTYMKYGLYPRQVNDKGCFPFMRSTQGPYLTTGKPETIPLHLQHGCTPAEGTNETIEVDPADQWASLNFIGGATFKTIVFSVDEHDMWVYEVDGHYIVPQRVNTVHMYAGERYAVMIKLDKTPKDYTIRVADSGLTQVISAFATLRYKGGIQGSDSVGVIDYGGQNSTKDGSVITLDREHLPPYPPNPPARKADAMHVLSTHRWKSAWQYTMSGHGMYEEDRSAYGPLLYDPHSADAMDEGLVIRTKNGSWVDLVLQVGSLPGQPQEFPHMMHKHTGKTWQIGSGMGIWNYSSVEEAIAAEPHNFDLDTPKWRDTFVTSFDGSAWIVLRYQVTNPGPWLFHCHIETHLAGGMAIAILDGIDVWPQIPAEYGPDQRGFMPGTLPELESGGKQGTVDKQCPLLAVSPSGGPKKDSGETSASDSRWETLIRGLIQVLQGWLSDEASSRSS
What is the function of this protein?
Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655).  The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488).  The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881).  The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488).  Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488).  Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
What are the official names of this protein?
Multicopper oxidase GIP1, Aurofusarin biosynthesis cluster protein GIP1, Gibberella pigment protein 1, Laccase-1.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space.
Protein: SEC23_ASPTN
Sequence: MDYEALKDYWTDIEDRDGIRLSWNKFPSSRMEASRLVVPIGAVYTPLKERPDAPLLQYAPVTCKPPCNGVLNPYANVDDRARIWICPFCLMRNPLPPQYKDISATVVPPELHPLNTTIEYQLPRGPRPAPPPPIFVYVVDTCQEEDSLKALKDALVVSLSLLPPNALVGLITFGTMAQVHEIGYTECAKSYVFRGSKEYAAKQVQEMLGLSQGMRPAMPNQPPQGPLGPAARFLLPVQQAEFQITNVLEQLQRDPWPVANDKRPLRCTGVALGVAVGLLETSFQNAGARIMLFTSGAATEGPGLVVGHELKEPIRSHHDIDRDNIKYYKKAVKFYDNMAKRAAHNGHIVDIFAGCLDQVGLLEMKNLSNYTGGHMLLTDSFTSSQFKQSFIRVFDKDANDNLLMGFNASLEVLTTKELKVTGLIGHAVSLNKKSSSVGETECGIGNTCAWKMCGIDPASSYGIYFEVANQGGPAAVQPGTQKGVMQFLTYYQHSSGHYHLRVTTVGRELSGPAGDPTLAQSFDQEAAAVLMARIAVFKAEVDDGPDVLRWVDRMLIRLCSRFADYRKDDPTSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVGDSLVMIQPTLDSYSLEHEGSQPVLLDSASIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENIKALLEQPKEDARELIADRFPLPRFIVCDAGGSQARFLLSKLNPSTTHTTGGYGGGVTSQTIFTDDVSLQTFMDHLMKLAVSGTS
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein sec23.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ILVH_SALTY
Sequence: MRRILSVLLENESGALSRVIGLFSQRGYNIESLTVAPTDDPTLSRMTIQTVGDEKVLEQIEKQLHKLVDVLRVSELGQGAHVEREIMLVKIQASGYGREEVKRNTEIFRGQIIDVTPTLYTVQLAGTSDKLDAFLASLRDVAKIVEVARSGVVGLSRGDKIMR
What are the official names of this protein?
Acetolactate synthase isozyme 3 small subunit, ALS-III, Acetohydroxy-acid synthase III small subunit, AHAS-III.
What is the protein family that this protein belongs to?
Belongs to the acetolactate synthase small subunit family.
Protein: SYS_PSEFS
Sequence: MLDSKLLRSNLQDVADRLASRGFALDVARIEALEEQRKTVQTRTEALQAERNARSKSIGQAKQRGEDIAPLMADVERMGTELSDGKVELEKIQSELDSILLGIPNLPHESVPIGEDEDGNVEVRRWGTPTAFDFEIKDHVALGELTGGLDFETAAKMSGARFALLRGPIARMHRALAQFMINLHTAEHGYEEAYTPYLVQAPALMGTSQLPKFEEDLFKISRDGEADLYLIPTAEVSLTNIVSGEILDAKQLPLKFVAHSPCFRSEAGASGRDTRGMIRQHQFDKVEMVQVVEPSTSMEALEGLTANAERVLQLLELPYRVLALCTGDMGFSAVKTYDLEVWVPSQDKYREISSCSNCGDFQARRMQARFRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPEVLKPYMAGVEVIR
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_MESHJ
Sequence: MYKRLVQEFFPKLDFENLEKYVNLIEFSNKNFNLTAFSGDILWKEGIFESIFTMNFIVGLVNNKENKKLKILDIGAGSGFPSIPFLITNPEIELTISESMQKRCQFLKDVSEKLDLKFNLICKPVQEINPQKFDIITARAVANLEKLEKITKKIHFPKTLLAFIKGPKVFNEVQNCKNCNYKIIKVNNNINKKIFIAFKQVS
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_GRABC
Sequence: MAMPEFTLRQLLEAGVHFGHHTRRWNPRMAPFIFGVRNQVHILDLQQTVPLLDRSLRAIRDVVAGGGRVLFVGTKRAAAEYVAESAQRCGQYYVNHRWLGGMLTNWKTITGSIKRLRQIDEMLAGDTTGLTKKEVLDITRDREKLERALGGIKDMGGLPDILFIIDTNKEKLAVEEANKLGIPVVAVLDSNSDPSGVTYPIPGNDDAIRAITMYCDLVASAVLDGISAEMIASGRDLGAAEELAPEILPEPEAEQATA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: CSRA_BORHD
Sequence: MLVLSRKANESIKIDSNIEISILEIKKDSVKIAIKAPENIKILRSEIYDIIKEENKKSILQDKNNIHKIKNLFDYFNK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_MOUSE
Sequence: MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
What is the function of this protein?
Chaperonin implicated in mitochondrial protein import and macromolecular assembly.  Together with Hsp10, facilitates the correct folding of imported proteins.  May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.  The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring.  In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10.  This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components.  Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
What are the official names of this protein?
60 kDa heat shock protein, mitochondrial, 60 kDa chaperonin, Chaperonin 60, CPN60, HSP-65, Heat shock protein 60, HSP-60, Hsp60, Mitochondrial matrix protein P1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: LAMB4_DANRE
Sequence: MLLRLELSALLLLLIAAPVRLQDECVGNSCYPNLGDLMVGRAAQLAASSTCGLYRPQNYCILGYLENERKCFTCDSRSPYNDYHNPSSHRIENIITTFQPERKMKWWQSENGVHEVSIQLDLEAMFQFSHLILTFKSFRPASMLVERSKDFGRTWKVFRYFAEDCANSFPGISEGPAHSIDDLVCDSRYSGAEPSTEGEVVLKALDPSFDIHDPYDSTIQGLITLTNLRVNFTRLLTLGDTLLTRRKRNPQDKYYYALYEMVVRGSCFCNGHASQCIPVDGARGDTFTEPGMVHGRCVCQHNTAGYNCERCQDFYHDAPWRPGGKADSDVCKRCNCHSHSEKCHFELARYLATGGVSGGVCDDCRNNRIGPQCELCGPFYYQDPQRSVDDPYACIPCDCDLDGSVDRGLCDPVNGQCVCKQNIEGERCDRCKVGFYGFSRDDPSGCQLCRCNFLGTIQVGNPCDPTTGRCICEHFAYGSQCDQCLPGYWGLGNTVYGCIPCDCDIGGALKTECSSVDGQCKCRPNMVGQKCNDPAPGYFLAPLDFYIYEAENAAPLAVISPFIGPPPFVYPTEGIPERPTKLPLCPPAPKPSSVPYREHITVQPSPAPHNPQVTLPMCEHYFRQRGYDFKISNGRLVVVKREKRQTRRRRQGQRTIPFEPGSPLQILLRQRANDQSITWTGLGFVRVQDGAGLRFTVSNIPATLDYYVVVRYEPESTDDWTAIVSILSIGSEDERCPNDQSNKMFTLPASGRTATLDLPVCLSDGNQYHVDITFRKQPSEDPHSSSFILIDSLGLIPKVESVPNFCSQSYLSQFQQYRCIELAVQAGGQTLPEVCEMLIGSMSAFIHNGAVSCNCHHVGAYGSSCSKFGGQCQCKPNVIGRCCDSCAPLTYGLGPNGCSPCDCDRSGSTTELCDQTTGQCSCRDGITGLQCNRCYPGYYGFPLCRRCQCNRLADICDPITGDCLDCREHSAGRNCERCEEGYVGDPVSGQPCEPCLCPDLNGSGRFFAFSCNKDPRSGAPYCECLPGHTGPQCDSCSPGFYGDLRLPGGRCKECCCNNNIDPRDGDACDPVTGECLRCLHNTEGPRCQSCKRGYYGNALAQDCKECSCDRRGTDDSKCPAGSPCFCDQDTGQCPCRPGVQGALCNECDDGYWNMDGDYGCQPCNCNREHALNYICDKITGQCLCQPEYGGRICDECGPNHFGNPDLQCMFCDCNLEGTVHPACDAYTGECLCKPGVTGPFCDECAPGHNNNFPACEPCHACNHLWEKIISDLSLDAERIETMMPCPEDFRSRPELQHLQNLLEKLQNVLNMGAQDELKKLEELLARIRNETEIIDPNIIIIDPTLLLNTDIDYIRLEFNKLLKNLREKAKEGPVTDIKAVNDIFNKIKKFYDEFTDSEKKVEAAKKVQEASRKTREKVTLELAKCQIGEMDKLERKVKALSAANINEEVCGAPGDAECEKAKCGGALCGKCGGPDCTGSLPISLNASKLAEMTEKNITALRSQLKEADAQLRNASEMTSYVKDQAENMMDKINRTKTKYEQEKTDTKALIEKVKTYLQDELVKPEDIEKLANAVLSIQLPKSPDEIKDMIEDIKKILANITEFNDDLEYLEKQAKIAGNMKERAKEILNRTELINVKEIEKALNDTAKLHDKIFNDLDEAEQNNDVIREKVNETEPKLKNIEDHLNLTRAKTLLDEIEALKNKTEMNRAQGKEAKDTADAALNSANDTGKDLEELKEQFEKLKLNSTNQNVSSEANERLKNITMEAENLAKHVEDKMKEIEDLEEKILLSNERKDEMRKELEALQKEADDLKKFIVDKVQRYNLCSP
What is the function of this protein?
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
What are the official names of this protein?
Laminin subunit beta-4.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: MRP5_RAT
Sequence: MKDIDMGKEYIIPSPGYRSVRDRSTIPGTHGDREDPSSGEQISLECQDALETAARVEGLSLDISVHSHLQILDEEHTKGKYHHGLSALKPFRTTTKHQHPVDNAGLFSYMTFSWLSPLAQVVHKKGELLMEDVWPLSKYESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFVVKHLLEYTQATESNLQYSLLLVLGLLLTEVVRSWSLALTWALNYRTGVRLRGAVLTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSTQSSPKLTPKVKKDKRAPKGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHAGSMRLQRTLYNIDLEIEEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKEASGSQKSQDKGPKPGSVKKEKAVKSEEGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNVGSTAFSTWWLSYWIKQGSGNSTVFEGNRSSVSDSMRDNPFLQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPPHDWPQEGEITFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLAIIPQEPVLFSGTVRSNLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMCAAAENKVAVKG
What is the function of this protein?
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells.  Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro).  Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins.  Confers resistance to the antiviral agent PMEA.  Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated.  Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (By similarity).  May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity).
What are the official names of this protein?
ATP-binding cassette sub-family C member 5, Multidrug resistance-associated protein 5.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Golgi apparatus lumen. Endosome membrane. Cytoplasmic granule. Apical cell membrane; Multi-pass membrane protein. Note=In most cells, routes to the basolateral plasma membrane, but in the brain capillary endothelial cells that form the blood-brain barrier, resides in the apical membrane.
Protein: SCC3_YEAST
Sequence: MTAVRRSTRIRTKSQVIEEDYDDEQNTSAQHVESDKITAKTQHEEEEEQDTGESEESSSEDDYEDQDDDDYVDTATAKRKSRKRKPKSASNTSSKRQKKKPTSAQKSAVSHAPAYHRSKKDQDQYLEIAKDFQPTELFDILSTSEDVSIEELLREWLETYSENRDKFLQEFINLLLNCCGSVARVEDHDVHSNESSNETIGEIQLLFQRQKLHEFYLLISKENKKRKNFKMGPLYQNFAEFMTKLLEVANDLQLLYVESDEDDTQIVTGNLVLDLLTWLSSFSVCKIRCFRYISTLTLYLFQDYLTQQAVNLEKNYLAKLSKQLSLEEKKKRPNNKTLEKLESTIAETQGSKVVIDSIIDNIVKLCFVHRYKDVSDLIRSESMLHLSIWIKNYPEYFLKVTFLKYFGWLLSDNSVSVRLQVTKILPHLIIQNHNSKSTDNSAIRQVFERFKTKILEVAIRDVNLDVRIHSIQVLTEASSLGYLDDSEILIISSLMFDEEFDPFKTSSFNKRSKFLSTVAKFLARVIKEKFDEFIKTHEDLPKEVDGLEVGPVVQVGIFIKILNDSLIYHLKDCAEVDSRTKIRMLTQAAEFLSPYISTHLKTICNLLISDTESNELIQKLQNSANNNSDDEDVDDEELDITPLFPIDRNSTILYLNVFHGLCAGANNPKIQTKDSVKEIVLPLFYDLLNAASIESADILCPLLESFITFSLDDWISIGYETELKKITDKTIKAFMDSTIGNSKVDMKYDIFAKFIHHIHHFEKKELQEKFLNQIATLKIHLKKFLQEKMDPNNSRDDYKDLTCSLYELYINKLTILGRDYPIEVDEELLQLFLNNFVSRIPIMFQDFDDSTAQEINFKMLVLLATWNLEKWREIIEKVRDYENSISKDLRSVWKPIAAIIGRLNTLVISLAATNETFENINSLFYLKWSACTSLMDIIVAIKIFELKLPADATTWRYSMSEQFPFYLHDNASKVLLKIFLYLESLFAKQVDVQLERVADEDANLNDLPETGFFENIETEFLLFTVKLKGLMKLNILDERFASRVALNKEKLGPLFKKIVDDTIMENPEPNKKNIQKAKSNQTQREKAPLQPNSERETDHANTENNDPDIPMTIDLEPIEESSQNNSELAPIEEHPTVVDAIDNSDEITQD
What is the function of this protein?
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication.  The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.  At anaphase, the MCD1/SCC1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.  The cohesin complex may also play a role in spindle pole assembly during mitosis.
What are the official names of this protein?
Cohesin subunit SCC3, Irregular cell behavior protein 1.
What is the protein family that this protein belongs to?
Belongs to the SCC3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin except at centromeres, where cohesin complexes remain. At anaphase, the MCD1 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Protein: CARB_STRP8
Sequence: MPKRKDIQKIMVIGSGPIIIGQAAEFDYAGTQACLALKEEGYKVILVNSNPATIMTDKEIADKIYIEPLTLEFVNRIIRKERPDAILPTLGGQTGLNMAMALSKAGILDDLEIELLGTKLSAIDQAEDRDLFKQLMQELDQPIPESTIVKTVDEAVTFARDIGYPVIVRPAFTLGGTGGGICSSEEELCEITENGLKLSPVTQCLIERSIAGFKEIEYEVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPTQTLSDIENQMLRDASLKIIRALKIEGGCNVQLALDPYSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMINPITGTTYAMFEPALDYVVAKIPRFPFDKFEHGERQLGTQMKATGEVMAIGRNLEESLLKACRSLEIGVCHNEMTSLSNISDEELVTKVIKAQDDRLFYLSEAIRRGYSIEELESLTKIDLFFLDKLLHIVEIEQELQMHVDHLESLKKAKRYGFSDQKIAEIWQKDESDIRAMRHSHSLCPVYKMVDTCAAEFDAKTPYFYSTYELENESVQSNKESILVLGSGPIRIGQGVEFDYATVHSVKAIQKAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDLEQPKGVIVQFGGQTAINLAQSLSDAGVTILGTQVEDLDRAEDRDLFEKALKELGIPQPQGQTATNEEEALEAAKKIGFPVLVRPSYVLGGRAMEIVENKEDLREYIRTAVKASPEHPILVDSYIFGKECEVDAISDGKSVLIPGIMEHIERAGVHSGDSMAVYPPQQLSKQIQETIAEYTKRLAIGLNCIGMMNVQFVIKNEQVYVIEVNPRASRTVPFLSKVTGIPMAQIATKLILGQTLKDLGYEDGLYPQSQLVHIKAPVFSFTKLAQVDSLLGPEMKSTGEVMGSDTSLEKALYKAFEANNSHLSEFGQIVFTIADDSKAEALSLARRFKAIGYQIMATQGTAAYFAEQGLSACLVGKIGDAANDIPTLVRHGHVQAIVNTVGIKRTADKDGQMIRSSAIEQGVPLFTALDTAKAMLTVLESRCFNIEAI
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: TUS_ENT38
Sequence: MATYDLIERLNSTFRQIELELVTLTERLKGCRLLAARVFTLPDVAKGAEHDELNTIEVEQHIGQEAVALTLAHYRHLFIHQQSEKRSSKAAVRLPGVICLQCDGALREEIESQIAHINTLKMAFEKIITEESGLPPAARFEWVHRQLPGLITLNAYRSLTVLRQPATLRFGWANKHIIKNFTRDDVLSLLEKSLKSPRTVTPWSREQWIERLEEEYDNIAALPAETRLKIKRPVKVQPIARVWYAGQQKQVQYACPTPMIALFDAEQGAMVPDIGELLNYDADNIQHRYKPQAQPLRLIIPRLHLYVAE
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_BORAP
Sequence: MSKNIDDKNEDGKKIKIIKLRKKVVKIVTHNDLSGKNNPSGSTDLHKHNNKVEYSHSRDGRTGGYSQNRDGRTGGYSQNRDGRTGGYSQNRDSLTSQYQGSTKKTYVAKNNTQNKYTTSVSFRRVIKTKVPSIVSSASSTDSENSKELNRKLGEKKKQQQESQKSYKRKKAETESKTIEQKVFEQLQKKKRENLANPIPKSIDIMGSITVSDLARKMNLKSSDLIAKLMALGVMVTINEKIDSDTATILVEEYGSKVNVVSIYDETVIEEEVEDQSKRIEKPPVITIMGHVDHGKTRLLSVLQNIDINQTESGGITQHIGAYTIVYNSREITFLDTPGHEAFTMMRSRGAQVTDIVVLVVSAIDGVMPQTIEAINHAKEANVPIIVAINKIDLPDSNPDKIKHQLSEYDLVPEDWGGDTIFVLISALKNIGISELLDMILLQADMMLLKANPSKRAIGKVLDAKIDLGRGIVCSVIIEDGTLYVGDSFVGGACYGKVKALINDKGVSVKSVGPAKAISVLGFSSMPQAGDPFQVTKTEKEAKLISSKRQDLKKYESSKNVKKVTMLNLYDSIKEGTLKELKIILKADVQGSVEALKNSLEKLTNDEVRVRVVHSSAGVITETDISFASASDAIVIGFHVRPTVKAQILADQEKVEIRKYNVIYDAISDVKSVLEGMLEPDVEQQFIGFAEVRAVINVPKVGVIAGCYVSRGLIKRDAITNVMRDGLQIHSGKISSLKRFKDDVKEVAEQYECGIMIDNYANIKEGDIIEAFEVKKVKKTFKT
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR70_HUMAN
Sequence: MERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAEEEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDSPYWVSPAYSKTQPKTMFAQVESDDEEAKNEPEWKKRKI
What are the official names of this protein?
WD repeat-containing protein 70.
What is the protein family that this protein belongs to?
Belongs to the WD repeat GAD-1 family.
Protein: RL23_GEOUR
Sequence: MNIYSVIKKPLITEKTTIEKDERNIISFVVSSDANKIEIKDAVKTLFNVDVASVKTVNVAGKVKRVGKNIGKRSNWKKAYVTLKEGSNVDFFEA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RECR_CLOBJ
Sequence: MDFYPIAIEKLIEEFAKLPGIGYKTAQRLTLYVLNLPKEEVKEFSEALVKARGTIKYCSVCGNFTDKDPCAICSNPNRNKSIICVIEQPKDIMSMEKIREYNGVYHVLHGNISPMAGRGPEDIKLKELIRRIDGSVNEVIVATNPNVEGEATAMYISKILKPLGVKVTRIAHGVPVGGDLEYADEVTLAKALEGRIEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: DCYD_SALEP
Sequence: MPLHHLTRFPRLELIGAPTPLEYLPRLSDYLGREIYIKRDDVTPIAMGGNKLRKLEFLVADALREGADTLITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQIEMCDALTDPDAQLQTLATRIEAQGFRPYVIPVGGSSALGAMGYVESALEIAQQCEEVVGLSSVVVASGSAGTHAGLAVGLEHLMPDVELIGVTVSRSVAEQKPKVIALQQAIAGQLALTATADIHLWDDYFAPGYGVPNDAGMEAVKLLASLEGVLLDPVYTGKAMAGLIDGISQKRFNDDGPILFIHTGGAPALFAYHPHV
What is the function of this protein?
Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives.  It could be a defense mechanism against D-cysteine.
What are the official names of this protein?
D-cysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.