PharMolix/UniProtQA huggingface dataset:
Protein: CLPS_NOSS1
Sequence: MSTAPTVTPERSNQTVRKTYPNYKVIVLNDDFNTFQHVAECLVKYIPGMTGDLAWDLTNQVHYEGQAIVWVGPQEPAELYHQQLRRAGLTMAPLEAA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RLME_BURO0
Sequence: MAKNRFNQHWLHDHINDPYVKMAQREGYRARAAYKLKEIDEQDKLIRPGQVIVDLGATPGSWSQYARNKLAQGKKRDAEREGGIDGTIVALDILPMEPIADVHFLQGDFREDDVLHQLEEVLEGRAVDLVISDMAPNLSGVASADAARIEHLCDLALEFAQNHLKPDGALLVKCFHGSGYSQIVEKFKQQFKVVAPRKPKASRDKSSETFILGRQLKHPR
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Protein: SOX1A_DANRE
Sequence: MYSMMMETDLHSPGPQTNTNPGQTGPNSGSKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLGGAGGGVGMSPAGVGQRLESPGGHGGSASAGYAHMNGWANGTYSGQVAAAAAAAAMMQEAQLAYSQHPGSGSHHHHAHHHHPHNPQPMHRYDMTALQYSPISNSQSYMSASPSGYGGISYTQHQNSSVATSAAIGTLSSLVKSEPNISPPVTTHSRGPCPGDLREMISMYLPTGESGDPSVQSRLHALPQHYQSTTAGVNGTVPLTHI
What is the function of this protein?
Transcriptional activator.
What are the official names of this protein?
Transcription factor Sox-1a.
What are the subcellular locations of this protein?
Nucleus.
Protein: 107L_IIV6
Sequence: MDPIRCFSCNKIMKSPNEKGMVFVRNMKKEDREQFFKKFNYTRLCCKRMYLSAVNFQDELFQYENARSTLNVDGTITKPF
What are the official names of this protein?
Uncharacterized protein 107L.
Protein: PPR21_HUMAN
Sequence: MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR
What is the function of this protein?
Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623).  May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571).
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 21, Coiled-coil domain-containing protein 128, KLRAQ motif-containing protein 1.
What are the subcellular locations of this protein?
Early endosome.
Protein: Y1421_METMJ
Sequence: MRLTWLGHACFSLAGSRTIVIDPFIPEGSLPAEPDIVAVTHAHADHLGIATELSKKTVAVNEVAKYLKTKGVPAEPMNLGGTITVDGVRFTMTPALHSSWLEDEGPGFYGGVAAGFVITMDGVSVYHAGDTALFSDMQLIRDLYRPDVALLPVGGCFTMGPEEAMIAARYIGAPLVVPMHYDTFPAIRQNLEEFKRTIERTTSIRVALLSPGESIEVGPEKAGE
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Memar_1421.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: GUAC_ECOK1
Sequence: MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYSVEEWQAFINNSSADVLKHVMVSTGTSDADFEKTKQILDLNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVMLGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRIFNNL
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Protein: YNFA_SALAR
Sequence: MLKTTLLFFVTALCEIIGCFLPWLWIKRGASVWWLLPAVASLALFVWLLTLHPAASGRVYAAYGGVYVCTALLWLRVVDGVRLTVYDWCGALIALCGMLIIVVGWGRT
What are the official names of this protein?
UPF0060 membrane protein YnfA.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CHAG_TRYCR
Sequence: MSHKVTKAHNGATLTVAVGELVEIQLPSNPTTGFAWYFEGGTKESPNESMFTVENKYFPPDSKLLGAGGTEHFHVTVKAAGTHAVNLTYMRPWTGPSHDSERFTVYLKAN
What is the function of this protein?
Cysteine protease inhibitor (PubMed:17561110, PubMed:11719560, PubMed:17502099, PubMed:18515357, PubMed:19143838).  Inhibits cysteine protease cruzipain (PubMed:11719560, PubMed:17561110).
What are the official names of this protein?
Chagasin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I42 family.
What are the subcellular locations of this protein?
Flagellar pocket. Cytoplasmic vesicle. Cell surface. Note=Flagellar pocket and cytoplasmic vesicles of trypomastigotes and to the cell surface of amastigotes.
Protein: RP44A_ARATH
Sequence: MLQSKVFNKKTRGGRIQKQVREVYLRDDIYCGAFSCKSCDSSAARLSSSKIIVVDTNVVLHQIDLLENKAIDTVVVLSVVLDEVKNRNRSVYNRIRLLCSNPARQFYVFSNHVHKDTYVQAMEKESANDHNDRAIRVATLWYQKHLGDTSQVLLVTNDRENKRKATEEGISAETIEAYVKSLGQPELLDLLAQPTNEDITMEDADDSRPSKRKLIYQEHKPMSEITAGLHRGIYHQGKLRVNRFNPYEAYVGSESIGEEIIIYGRSNMNRAFDGDIVAVELLPRDQWQDEKALSIAEEDDEEDDTVHLAPDNVDDAPRTSNLSHETSGDKNAAPVRPSGRVVGVIRRNWHSYCGSLEPMSLPAGSGGTAHALFVSKDRRIPKIRINTRQLQNLLDMRIVVAVDSWDRQSRYPSGHYVRPIGKIGDKETETEVVLIENDVDYSPFSSQVLACLPPLPWSVSSEDVSNPVRQDLRHLLVFSVDPPGCKDIDDALHCTSLPNGNFELGVHIADVTNFVHPGTPLDDEASKRGTSVYLVERRIDMLPKPLTEDICSLRADVERLAFSVIWEMSPDAEIISTRFTKSIIKSSAALSYIEAQARMDDSRLTDSLTTDLRNMNTLAKIMRQRRIDRGALTLASAEVKFDIDPENHDPLNIGMYQILEANQMVEEFMLAANVSVAGQILKLFPSCSLLRRHPTPTREMLEPLLRTAAAIGLTLDVSSSKALADSLDRAVGEDPYFNKLIRILATRCMTQAVYFCSGDLSPPEYHHYGLAAPLYTHFTSPIRRYADVFVHRLLAASLGIYKLPTVFQDRPQLTSVADNLNYRHRNAQMAGRASVELYVLIYFRTRPTDEEARVVKIRSNGFIVFVPKYGIEGPVYLTGKGEKGAGDWYVDEEKQKIVKMDGSLSYSVLQTVKIHMEVVEPQPNRPKLQLTLL
What is the function of this protein?
Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  Required for 5. 8S rRNA intermediate processing and the degradation of 5' external transcribed spacer (5' ETS), a maturation by-product of rRNA synthesis.  Is not involved in the degradation of turnip crinkle virus (TCV) RNA and significant virus resistance (PubMed:24244451).  Required for normal development of female gametophytes and early embryogenesis (PubMed:20798041, PubMed:24244451).
What are the official names of this protein?
Exosome complex exonuclease RRP44 homolog A, RRP44 homolog A, Protein EMBRYO DEFECTIVE 2763, Ribosomal RNA-processing protein 44A, AtRRP44A.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YBAI_SCHPO
Sequence: MSSSVSEECTPAKKKYDACFNDWYANKFLKGDLHNRDCDELFAEYKSCLLKALKTKKIDPLLEAARKED
What are the official names of this protein?
Uncharacterized protein C119.18.
What is the protein family that this protein belongs to?
Belongs to the TRIAP1/MDM35 family.
Protein: CH10_YERPB
Sequence: MKIRPLHDRVIVKRKEVESKSAGGIVLTGTAAGKSTRGEVLAVGNGRILDNGEIKPLDVKVGDVVIFNDGYGVKAEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCHF_CERS4
Sequence: MQPTSPAAPHRRLYTEEQRARRDATRWTLVQGILAPLQFLVFAISLGLVLWYLATGEGYAAATASILIKTFLLYTIMVTGAIWEKVVFGQYLFAPAFFWEDVFSFGVIALHTAYLWALFTGQPHGLQMGIALAAYATYVINAGQFLWKLRMARLDMEAAQ
What are the official names of this protein?
2-vinyl bacteriochlorophyllide hydratase.
Protein: Y4AK_SINFN
Sequence: MLVARLLRWALTVSLRLDPYGRKDEMAGAVGRFATKPVLQEAHARGRATA
What are the official names of this protein?
Uncharacterized protein y4aK.
Protein: OLEO3_BRANA
Sequence: MTDTARTHHDITSRDQYPRDRDQYSMIGRDRDQYSMMGRDRDQYNMYGRDYSKSRQIAKAVTAVTAGGSLLVLSSLTLVGTVIALTVATPLLVIFSPILVPALITVAMLITGFLSSGGFGIAAITVFSWIYKYATGEHPQGSDKLDSARMKLGSKAQDLKDRAQYYGQQHTGGYGQQHTGGEHDRDRTRGTQHTT
What is the function of this protein?
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil.  Probably interacts with both lipid and phospholipid moieties of lipid bodies.  May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
What are the official names of this protein?
Oleosin Bn-III, BnIII.
What is the protein family that this protein belongs to?
Belongs to the oleosin family.
What are the subcellular locations of this protein?
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface.
Protein: UVRC_PSEP1
Sequence: MSQVFDASAFLATCSGRPGVYRMFDGEARLLYVGKAKNLKKRLASYFRKAGLAPKTAALVARIAQVETTITANETEALLLEQNLIKEWRPPYNILLRDDKSYPYVFLSDGEFPRLGIHRGAKKAKGRYFGPYPSAGAIRESLSLLQKAFSVRQCEDSYYANRTRPCLQYQIKRCKGPCTDLVTAEEYAEDVRHSVMFLEGRSQQLGNELNAEMEKAAMALDFEKAAELRDQIALLRRVQDQQYIEGGSGDVDVIAAFVNPGGACVHLISVRGGRVLGSKNFFPQVGIEEEVAEVMAAFLSQYYLGNAERELPGELIVNVVHEDFNAITEALHTLRGRELTISHRVRGTRARWQQLAVTNAEQALNARLANRQHMAARFEALAEVLGLDEVPQRLECYDISHSSGEATVASCVVFGPEGPIKSDYRRFNIEGVTAGDDYAAMHQALTRRYGRIKDGEGKLPDVLLVDGGKGQLNMARDVMQALGFTDLTLLGVAKGVTRKAGFETLYLNDVHHEFTLKGDSSALHLIQQIRDEAHRFAITGHRARRGKARRVSSLEDVAGVGPKRRRDLLKHFGGLQELNRASIDEIAKAPGISKKLAESIYASLHSE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4C2_SYNP6
Sequence: MEIGTFPWLTTIILLPIVAALFIPLLPDRDGKGTTIRWYSLIVGLVDFILLVVAFWTSYDFSNPDLQLVESYAWVPQIGLNWSVGADGLSMPLILLTGFISTLAMLAAWPVTFKTRFFYFLMLAMYGGQILVFAVQDLLVFFFAWELELIPVYLLLAIWGGKRRQYAATKFILYTAGSSLFILVASLAMAFSGDVISFDFQTLAAKEYAIGFQLLLYAGFLIAYGVKLPIVPLHTWLPDAHGEATAPVHMLLAGILLKMGGYALFRMNAGMLPEAHARFAPILVLLGVVNILYAALTSFAQRNLKRKIAYSSISHMGFVLIGLGSFTQLGLSGSMLQMVSHGLIGASLFFLVGATYDRTHTLMLDEMGGVGQKMRKMFAMWTTCAMASLALPGMSGFVAELMVFVGFATSDAYGLPFKVVVISLAAIGVILTPIYLLSMLREIFFGPENKTLTEHETLVDAEPREVYIIACLLVPIIGIGLYPKLTTQVYDATLVQLTERLRSAVPVIAQQAEASRDRLSHFPGQAHRQAPPLG
What is the function of this protein?
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4 2, NAD(P)H dehydrogenase I, chain 4 2, NDH-1, chain 4 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PYRG_ALIF1
Sequence: MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLKVTMMKLDPYINVDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFIRTKMTKRNNFTAGRVYADVLRKERRGDYLGATIQVIPHITNAIKERVISGAEGHDIAIVEVGGTVGDIESLPFMEAIRQLAVELGRERAMFMHLTLVPYLAAAGEVKTKPTQHSVKELLSIGIQPDILVCRSDRVIPANERKKIALFCNVQEKAVISMKDVDSIYKIPQLIKAQGTDDLVCQRFGITAPEADLSEWEQVIYEEANPTGDVVIGMVGKYIELPDAYKSVNEALKHAGLKNRLSVTIKYVDSQDVESKGTEILEGLDAILVPGGFGDRGVEGKILAAQYARENKVPYLGICLGMQVALIEYARNVANMEGAHSSEFSKDTKFPVVGLITEWIDSEGNVEERTEKSDLGGTMRLGSQLCHLAKGSKARELYGNATVEERHRHRYEVNNNLLPQLEKAGLKVSGLSADKKLVEIIEIPNHPWFVAAQFHPEFTSTPRDGHPLFEGFVKAAGESVRGELEK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: TOLB_AGRVS
Sequence: MKTFSLLRILIVLVGMAGAFATPAMALVEININKGNVEPMPIAIPDFLSANGIGAKISAVVEADLKRSGLFAPVNHGAFIDKQINPDQAPNMQNWTVLNAQALVVGRITQEGDGRLRAEFRLWDTYAGQQMSGQQFYTQPENWRRVAHIIADAIYERITGEKGYFDTRIVFVAESGTKTDRKRQLAIMDQDGENVRMLTNTANLVLTPRFSPNRQEVTYMSFEGNQPRVYLLQLETGQREVVGNFPGMTFSPRFSPDGQRVIMSLQQDANSNIYTMDLRSRTTTRLTSTAAIDTSPSYAPDGRRIVFESDRGGRQQLYVMNSDGSGQTRISFGEGSYSTPVWSPRGDLIAFTKQSGGKFSIGVMKPDGSGERLLTTGFHNEGPTWAPNGRVLMFFRQAAGSGGPQLYSIDLTGYNEQLVKTPSFASDPAWSPLLE
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SPY2_HUMAN
Sequence: MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT
What is the function of this protein?
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity).  Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity).  Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity).  Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561).
What are the official names of this protein?
Protein sprouty homolog 2, Spry-2.
What is the protein family that this protein belongs to?
Belongs to the sprouty family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).
Protein: SGPL_CAEEL
Sequence: MDSVKHTTEIIVDLTKMHYHMINDRLSRYDPVVLVLAAFGGTLVYTKVVHLYRKSEDPILKRMGAYVFSLLRKLPAVRDKIEKELAAEKPKLIESIHKDDKDKQFISTLPIAPLSQDSIMELAKKYEDYNTFNIDGGRVSGAVYTDRHAEHINLLGKIYEKYAFSNPLHPDVFPGARKMEAELIRMVLNLYNGPEDSSGSVTSGGTESIIMACFSYRNRAHSLGIEHPVILACKTAHAAFDKAAHLCGMRLRHVPVDSDNRVDLKEMERLIDSNVCMLVGSAPNFPSGTIDPIPEIAKLGKKYGIPVHVDACLGGFMIPFMNDAGYLIPVFDFRNPGVTSISCDTHKYGCTPKGSSIVMYRSKELHHFQYFSVADWCGGIYATPTIAGSRAGANTAVAWATLLSFGRDEYVRRCAQIVKHTRMLAEKIEKIKWIKPYGKSDVSLVAFSGNGVNIYEVSDKMMKLGWNLNTLQNPAAIHICLTINQANEEVVNAFAVDLEKICEELAAKGEQKADSGMAAMYGMAAQVPKSVVDEVIALYIDATYSAPPSTSN
What is the function of this protein?
Cleaves phosphorylated sphingoid bases (PSBs or S1Ps) at the C2-3 carbon bond to yield a fatty aldehyde and phosphoethanolamine.  These bioactive sphingolipid metabolites are essential for normal development, intestinal integrity, growth and reproduction.
What are the official names of this protein?
Sphingosine-1-phosphate lyase, S1PL, SP-lyase, SPL, Sphingosine-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: RL1_ACIB5
Sequence: MAKLTKRQKAIAAAVEANKVYTLEEAVQVLNSLPAAKFKESLDISVNLGVDPRKSDQVVRGATTLPAGTGKTVRVAVFAQGAQAEAAKEAGADVVGFDDLAESIQGGNLDFDVVIAAPDAMRVVGKLGTILGPRGLMPNPKVGTVTPDVAGAVKNAKSGQARYRVDKAGIIHAAIGQVGFDAAAIRQNVETLVADLEKLKPATSKGVYIKKITLSSTMGPGLTVDVNNVSN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: COX20_ASHGO
Sequence: MAWWPFSRNNKPGVPEQDQVAAAPVQQRPAEPLPTNYTPGQRLLLEDTRPRFDTQSSASQQAVQRERATLADAWKTVRWEDFSLERMAGIPCFRDAGMAGFSAMVVAGSVTFLFHKNPVRAANWGVGGLLLGSIVGWEQCRMQRRRSFQVAEMARQTVAAKEAPMLRKPDNAQKAGAVSQASELPPKKPWYRFW
What is the function of this protein?
Involved in the assembly of the cytochrome c oxidase complex.
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX20, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX20 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SCXI_CENSC
Sequence: MNSLLMITACLVLIGTVWAKDGYLVEKTGCKKTCYKLGENDFCNRECKWKHIGGSYGYCYGFGCYCEGLPDSTQTWPLPNKTCGKK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  Affects channels from chicken and frog.
What are the official names of this protein?
Beta-toxin CsEI, CsE-I, Neurotoxin I.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SSPH_BACHK
Sequence: MDVKRVKQILSSSSRIDVTYEGVPVWIESCDEQSGVAQVYDVSNPGESVHVNVTALEEK
What are the official names of this protein?
Small, acid-soluble spore protein H, SASP H.
What is the protein family that this protein belongs to?
Belongs to the SspH family.
What are the subcellular locations of this protein?
Spore core.
Protein: PURA_LISMF
Sequence: MSSVVVVGTQWGDEGKGKITDFLSENAEAIARYQGGNNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGMVVDPKALVEELKYLHDKGVDTSNLRISNRAHIILPYHIRIDEADEERKGANKIGTTKKGIGPAYMDKAARVGIRIIDLLDKETFKEKLEHNLGEKNRLLERFYELEGFKLEDILEEYYDYGQQFKEYVCDTSVVLNDALDDGKRVLFEGAQGVMLDIDQGTYPFVTSSNPIAGGVTIGSGVGPSKINHVVGVAKAYTTRVGDGPFPTELFDTIGDTIREVGHEYGTTTGRPRRVGWFDSVVVRHARRVSGLTDLSLTLLDVLTGIETLKICVAYKLDGKTITEFPASLKDLARCEPVYEELPGWTEDITGVTSLDDLPVNCRHYMERIAQLTGVQVSMFSVGPDRAQTHVIKSVWRLA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPMA_KLEP7
Sequence: MSETATWQPSAPIPNLLKRAAVMAEIRRFFTDRGVLEVETPCMSQATVTDIHLFPFETRFVGPGHSQGLNLYLMTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPCYDMYRLINEVDDLLQQVLECQPAESLSYQQAFQRHLEIDPLSADKAQLREVAAKLDLSNIADTEEDRDTLLQLLFTMGVEPHIGKDRPTFIYHFPATQASLAQISPEDHRVAERFEVYYKGIELANGFHELTDAHEQRLRFEQDNRKRAARGLPQQPIDNNLLAALEAGLPDCSGVALGVDRVVMLALGAESIGEVIAFTVDRA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P).  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: ENB1_YEAST
Sequence: MLETDHSRNDNLDDKSTVCYSEKTDSNVEKSTTSGLRRIDAVNKVLSDYSSFTAFGVTFSSLKTALLVALFLQGYCTGLGGQISQSIQTYAANSFGKHSQVGSINTVKSIVASVVAVPYARISDRFGRIECWIFALVLYTIGEIISAATPTFSGLFAGIVIQQFGYSGFRLLATALTGDLSGLRDRTFAMNIFLIPVIINTWVSGNIVSSVAGNVAPYKWRWGYGIFCIIVPISTLILVLPYVYAQYISWRSGKLPPLKLKEKGQTLRQTLWKFADDINLIGVILFTAFLVLVLLPLTIAGGATSKWREGHIIAMIVVGGCLGFIFLIWELKFAKNPFIPRVYLGDPTIYVALLMEFVWRLGLQIELEYLVTVLMVAFGESTLSAQRIAQLYNFLQSCTNIVVGIMLHFYPHPKVFVVAGSLLGVIGMGLLYKYRVVYDGISGLIGAEIVVGIAGGMIRFPMWTLVHASTTHNEMATVTGLLMSVYQIGDAVGASIAGAIWTQRLAKELIQRLGSSLGMAIYKSPLNYLKKYPIGSEVRVQMIESYSKIQRLLIIVSISFAAFNAVLCFFLRGFTVNKKQSLSAEEREKEKLKIKQQSWLRRVIGY
What is the function of this protein?
Involved in the transport of siderophore enterobactin and so has a role in iron homeostasis.
What are the official names of this protein?
Siderophore iron transporter ENB1, Enterobactin permease, Siderophore iron transporter ARN4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein.
Protein: MARH3_BOVIN
Sequence: MTTSRCSHLPEVLPDCTGSAAPVVKTVEDCGSLVNGQPQYVMQVSAKDGQLLSTVVRTLATQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLEHWLSSSNTSYCELCHFRFAVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLATISGWLCLRGAVDHLHFSSRLEAVGLIALTVALFTIYLFWTLVSFRYHCRLYNEWRRTNQRVILLIPKSVNIPSNQQSLLGLHSAKRNSKETIV
What is the function of this protein?
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF3, Membrane-associated RING finger protein 3, Membrane-associated RING-CH protein III, MARCH-III, RING-type E3 ubiquitin transferase MARCHF3.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: MFSD3_MOUSE
Sequence: MHGKLLPLAGLYLVQGLPYGLQSSLLPILLRARGLSLTRVGLTKGLYAPWLLKLAWAPLVDRRGTPRVWLTLSTLSLGLVCGLLAVLPPPQAGQTGLPTTVMGLLLLLNLGAAVQDVALDTLAVQLLEPKELGPGNTVQVVAYKLGSALAGGGLLVLFPTLSWPLLFLLLAATYWLAAALAWAAPALGRLPWPQASEHTPHSSYLLQDLLAVPGTLWTAGFVLTYKLGEQGAGSLFPLLLLDHGASASDLGLWSGLGAVTCSIAGSSLGGALLARHWQPLKLLKTVLQLRLGSLACQTALLFHLNSPGASVDPGTVMRGAVLLSLCLQQFFGGVVTTATFTVMMHCSQLAPRALQATHYSFLATLELLGKLLLGTLAGVLADSLGPHLCFAVFLVLSALPVLDLRLAPSNLT
What are the official names of this protein?
Major facilitator superfamily domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.