PharMolix/UniProtQA huggingface dataset:
Protein: GGGPS_PYRAB
Sequence: MVKIGKVEMYINEELESGKKLHFVLIDPDDTHPEMAGRIAELCENVGVNAIMVGGSTGAEGEMLDNVVKAIKESSSLPVILFPGSHSGISKYADAIFFMSLLNSRNPFFITGAQALGAFTVKRYGLEPIPMAYIIVEPGETVGWVGDAKPIPRHKPKLAAAYALAGQYLGMRLVYLEAGSGSPEPVPPEMVRIVKSVIDVPLIVGGGIRTGDQVRELTKAGADIIVTGTAIESTKSIDEAKRKLEEIRRGLK
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_SODGM
Sequence: MKQFLDFLPLVVFFIVYNLYDIYYASGALIVASALVLVYTWLRYRKVEKVALITFVLVAIFGSLTLYYHNAEFIKWKVTVIYSLFAAALLISQFVFGKPLIQRMLDKEIHLPARVWNNLNIAWALFFLACGAANIYIAFWLPQSVWVNFKVFGLTGLTLVFTLLSGIYIYRYNNTH
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYT_STRZJ
Sequence: MINITFPDGAVREFESGVTTFEIAQSISNSLAKKALAGKFNGKLIDTTRAITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGFYYDTDNTAGQISNEDLPRIEEEMQKIVKENFPSIREEVTKDEAREIFKNDPYKLELIEEHSEDEGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLHVAGAYWRGNSDNAMMQRIYGTAWFEKKDLKNYLQMREEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRELERYIVNKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPTMDMGDGEEFVLRPMNCPHHIQVFKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHLFVTPEQIQEEFQRALQLIIDVYEDFNLTDYRFRLSLRDPQDTHKYFDNDEMWENAQTMLRAALDEMGVDYFEAEGEAAFYGPKLDIQIKTALGKEETLSTIQLDFLLPERFDLKYIGADGEDHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVDYAWEVAKKLRDRGVRADVDERNEKMQFKIRASQTSKIPYQLIVGDKEMEDETVNVRRYGQKETQTVSVDNFVQAILADIANKSRVEK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PVK2_NAUCI
Sequence: GSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DEOC_YERE8
Sequence: MTINYANYIDHTLLAMDATEEQIIKLCEEAKQHHFYAVCVNSGYVPVAAQQLAGTSVKVCSVIGFPLGAGLTEAKAFEAQAAIKAGAQEIDMVINVGWLKSGKIAEVKADIKAVRDNCASTPLKVILETCLLSDAQIVQVCEMCRELDVAFVKTSTGFSTGGAKEEHVKLMRATVGQDMGVKASGAVRDRATAETMIKAGATRIGTSSGVAIVSGQQASASSY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDEP_STAAE
Sequence: MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMYDNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHLNYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
What is the function of this protein?
Involved in multidrug efflux.
What are the official names of this protein?
Multidrug resistance efflux pump SepA, Antiseptic resistance protein SepA, Staphylococcal efflux pump A.
What is the protein family that this protein belongs to?
Belongs to the multidrug resistance efflux pump SepA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FPP4_ARATH
Sequence: MDRKSWPWKKKSSEKTATVTEVVDQENGKKPSYIQISFDQYTNLNGLKDEVKSYEEKVTKLEDQIKDLDLKLSTANADIVAKEVLVKQHSKVAEEAVTGWEKAEAEASALKTHLETITLAKLTVEDRAAHLDGALKECMRQIRSLKEENEQKLHDVIATKTNQMDNLRAEFESRIGEYEEELLRCGAENDALSRSLQERSNMLMRISEEKSQAESEIEHLKNNIESCEREINTLKYETHVITKELEIRNEEKNMSMRSAEAANKQHLEGVKKIAKLEAECQRLRTLVRKKLPGPAALAQMKMEVESLGFGDHRQDHRQRRSPVRPSSPLMSPMSHMSQVSEFSLDNMQKFHKENDLLTERLLAMEEETKMLKEALAKRNSELQVSRNLCAKTANRLQTLEAQMMSKSPTKRGFEMPAEIFSRQNASNPPSMASMSEDGNEDARSVAGSLMSELSQSNKDKANAKIKKTESANQLELMDDFLEMEKLACLPNGSNANGSTDHSSADSDAEIPPATQLKKRISNVLQSLPKDAAFEKILAEIQCAVKDAGVKLPSKSHGANLNGLTEEKVIAMSNETTEEKVTIVEVITQELSDALSQIYQFVTYLSKEATACSENRTFSQKVQEFSTTFEGVLGKEKTLVDFLFDLSRVLVEASELKIDVLGFHTSTVEIHSPDCIDKVALPENKALQKDSSGEHYQNGCSQSSDSEIPDDCNGTSGYEPKLATCKFTTEEFEGLKLEKEKAESNLASCEADLEATKTKLQETEKLLAEVKSDLESAQKSNGMGETQLKCMVESYRSLETRSSELEIELTSLKGKIENLEDELHDEKENHREALAKCQELEEQLQRNNQNCPNCSVIEDDPKSKQDNELAAAAEKLAECQETILLLGKQLKSMCPQTEQVASSPSQEQQALNPEEEEYATSTNPQDSKLSSPSDKDTPSMNTMKSPVASKHRHTKSNSSSSSSGLTPEKHSRGFSRFFSTKAK
What are the official names of this protein?
Filament-like plant protein 4, AtFPP4.
What is the protein family that this protein belongs to?
Belongs to the FPP family.
Protein: NPHP4_XENLA
Sequence: MKDWENIFSQSHIIPPHKQRCKHAPSEKAGYQICIETLEGTPFRQGVLERSVEVSCQLRMTLFDSTYHHFFGRTWKSSTKPIKAIPGKASKILFNEPIYFYTTLIDPSIMAVIEVVALSKKQGGSKQELSCGFGIMSLFSHQLEDDSSIQSGRLKLYYGTPRSLLHPTLKDPNELNQHMTLIENTCIQYSVRPHKVLPTVAHLFPENVLVSGSETIPGIMPSCDNSGDALKKPHVQKTVICYLDQICLFLYPTLEKFEEELTMLVNSDWLPKDDGNINGGSVSIQERRLHIGVHNGWVFVQKPQIVVVVPEAEMMRGHSTTSLKKKNIAQQKLSSTVQALVLRSRIRLPEMVNHHGFALVFLLEYVFSIPNGIHSKTPSAASSTSYMHMIRWASWTPSMEQGSADVALPLQGGPHHNPSNNLVYKMPPANMSSEEVQQVESGTVHFTFCAGSENQLEKTRDFAETTSKELIQSKKNVKMSNSKLVPETTFSPLESQVGPALSISQLTTSPRYPAISHSSKTAMQYIPSQLLPSPMAYQLSHAELPYASSITHLEADMSESHPNNSNGEHLQELLFSPVHAPIVAMGTQTGSTTSLLSRASLARLHSVEFPEILDCNNEVAEVVDPSNPVNFNLQREEADYLLCNEIVLQFLAFTRIHDGSTIWPESIFFTFQFYRFHHVTTPRLQLLQLESSDIATADPLTHVLVQINKDGSIKKGSPGFQIKYSVDPGFLKPGERKWFLRFLALQTLQIDIWDGESLLLIGSAAVEMKHLLRQGRTAVQVSHDLEVITTEYEQDLMVMSGDTAKQGTAKPIGVHTIIKGRLHMRMGNVGRPPEKKLKRRETLPPSNSRIITMHDGRTGFHGGSMLSNKSMNWKQSVCQAHKLADLDSELAAMLCSRMKEVSIAYQQTNSETDTTERRKKERMMAVRQQESQENANLRKSLIMAQHEERTQHTRDLQIIEAYRERTKPECISSMLNQAITSNYTVYATLGTAEFFEFELKNPYNIQYTVTIEIDSTDLRVITDTREWKHFKELTSTVTPIEENMFHVQPNTVIPQLYLRAKETVYIPFKYQTFCVDHTPMLQGPDAESLRKHSQLSQYKSNAMSSRRIKVSFKTSDGKLIAILQVNIEPQPHVVDQTFRFYHPELTFLKKSIRLPPWYTLPGAPVGTPGGEPDLQVRCSDINIICDSKKMGPGEPQDVFIKVAGGPSPQIKRFFIALYIDPWLAAPIQIWQIYVHSLKRVDVSCITGQLTQLSLVLRGTQVVRKVRAYSSHPEELKVDPDGVFVLPPNGIQDLHIGVRPQKAGSQFIYLNLVDVDQHQLVASWLVCVSCRKPVISKAFEIALPVGGEKGCNKRISYRNPYPTKKTYSLYTNRSDLLQFKENYFEVAAGETYSIGLRFAPSQTRGQEEILIFINDREDKNEETFCVKVRYE
What is the function of this protein?
Involved in the organization of apical junctions (By similarity).  Required for building functional cilia.  Involved in the organization of the subapical actin network in multiciliated epithelial cells.  Seems to recruit int to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as daam1 (PubMed:26644512).  May down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway.  Acts as negative regulator of the hippo pathway (By similarity).
What are the official names of this protein?
Nephrocystin-4.
What is the protein family that this protein belongs to?
Belongs to the NPHP4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body.
Protein: EQXF_GIBF5
Sequence: MEWGPGKTAQGRARLPSSRPREKPQLSCNLCGDAAHQPRVTTQDRIRHLESLVFDLMQQSSVTQGQHGGGTPFSPVGSARFPVNTAVATTGTDSGSMRSTGGGANYVVSSHWAAVLDGIAELKDHLDSEDEAVHSDVHGVESPTAEITGPQLLYGCPKPASKDEILASILSLSRPVVDRLVSRYFNSFEMSPAVLHSVEFLKEYEEFWDDPSSVSPLWLGLLFTIMCLATQFEKFRLDPGVQSPAALSMERDLQKMADAYKLRIGQCLVLGNYTKGGPYVLETLMLYIAAEVFSSTDAEIDIWILTGNTVQIALHMGYHRDPKHFKGMSSFAAEMRRRVWATLIEMDLGLSAQMGLPRMIKQWQTDTQEPSNLQDSDFDKATVEMPPSRPETELTPILYRLVKARLMTTVGYIWDFAADVRPYTYTEVERMDSKLDEARKSIPDCLKWHSFARCITDSPQIIMQKVVLETLVYRAKIILHRKFMLGPPENSADSKRIVLESALKLLDYQHMLQEESQPFCQLYQERWRVSSLVNHDFLLATSILCYYLQNTKREGMPVSESTPMDETIMVSLRRSYDIWLQSSDSSKEARKVVKALNVVLGVSNTSGTDSGLDSSMSSSVPSGCASSTINDYQSGVEIPAGLGSQFPVLDGAMMPNWATFADDLLAAPMATPSNEWQAMDAAETVDTMGSLAWPWNLQCHALAEKVNDESLD
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:28379186).  Plays a specific role in the induction of the cluster-specific MFS transporter MFS-T and thus regulates the detoxification of the toxic trichosetin in Gibberella fujikuroi cells (PubMed:28379186).
What are the official names of this protein?
Trichosetin biosynthesis cluster transcription factor TF23.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYY_ECOSE
Sequence: MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKRFQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENSAIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQGYDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTEGGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQYVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLMQALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCLICWK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECG_HALMA
Sequence: MSGSDGGGLMSSAGLVRYFDAEDQNTIRIDPRTIVATGVMFGLLMLVLNAMIV
What is the function of this protein?
Involved in protein export.  The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
What are the official names of this protein?
Preprotein translocase subunit SecG, Protein transport protein Sec61 subunit beta homolog.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL30_ACIET
Sequence: MTTQQTIKIQLVRSPIGTKESHRATVRGLGLRKLNSISELKDTPEVRGMINKISYLVKVL
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: YDHF_LACLA
Sequence: MSILPGFLLSFAIAIVSYLLNRFIFHSLGSATIAILLGIILGNLYFKQVTLFAGTAWSEKKLLEFSVMFLGATVTFQTIGKLGFSGVGFILIQMISTIIFVLFMGKKLGFSANVSALMASGNAVCGSSAIAAVEPVIGAETSEKRTSIAMVNLMGTILMLSLPFLGTWMFGNNDLLRGALIGGTEQSVGQVVASATMVNPNTTTLATLFKIMRIIMLVFVVLYFGFRSKKQKRNEQGPTQIKIKRNSFLPWYVLGFLVLCTLDTLIHFVPEVSATAKFLSGWCETIALAAIGLRLNLVEFIKAGKKLLIYGLSTLVFQVVLALILISLLIK
What are the official names of this protein?
UPF0324 membrane protein YdhF.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TBC30_XENTR
Sequence: MDVQAEDLFRDVESDAFVNESHGGTGFQQNFSAWPGAFQVAWPLTNHQDLASETQDNGNKSGGDEIDVSLCDSQQQGRSRTSSLVNGLLTELYDTYRGGAGCYYFRQQDSVDSSTEASGSDAFLSRSNPESGFLQELSERQSSRHQMLYLKQKDCSELKAIKDELNRRIAIQSAKLLRQVKQKDRLQHKVQKNCDIVTACLQAVSQKRRVDTKLKFTLEPSLGQNGFQQWYDALKAVARLPTGIPKEWRKRVWLTLADHYLHSISIDWDKTMRFTFNDRSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTIGYCQGFNILAALILEVMEGNEGDALKVMIYLIDKVLPDSYFANNLRALSVDMAVFRDLVRMKLPELSQHLDVLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNHTVLKIWDSVFFEGSEILLRVSLAIWAKLGEQIECCQNSDDFYSTMGRLTQEMLEDSLIDSNELMQTVYSMAQFPFPQLAELREKYTYNITPFPAPVKSASFSGRTSKMRDSDEENEIDEDDVNANAVGCLGPFSGFLAPELQKYQKQIKDQKEEQSLKASNIAELSPGAIDSCRSEYHAVFNSMMMERMTTDINALKQQYSRIKKRQLQQINQVYIAADKGPVSCILPSQVNNSPVINHLLLGKKLKQVNRSKNALHLPASKSSLLANEETKAKQNSPWRTHIRVHRKNIARAKGELGHGDTIGLIDEQNEVPKDQPDTSKETEETAQPPCSSAGEETSLDRTVMKVDGRSPEPVYQDENANVTVVQSKLEALELSPDAETEVSLEMSQTFQESQSDSHSSSSESESFKKSPKVQVFSPFPSVKPLKKSATARNLGLYGPNSRTPSVNFPHMSKTFNKAANGTTGSKKR
What are the official names of this protein?
TBC1 domain family member 30.
Protein: CYSC_SHEHH
Sequence: MSDIVWHQHSIDKQSRADQKGQKPILLWFTGLSGSGKSTLAGALERALFDAGFHTYLLDGDNVRHGLCKDLGFSLDDRDENLRRVGEVAKLMVDAGLVVLSAFISPTRAERERVRALFDDGQFIEVHVSTPIEVCEARDPKGLYSKARAGEIKNFTGISASYEVPTAAELIIDTSKGDLATQVSALLDYLAAIQVIDSEKLKKAI
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: RL2_ALKMQ
Sequence: MGIKKFRPTSPGVRQMTVSTFEEITKVDPEKSLLTPLSKSGGRNAHGKITVRHRGGGLKRHYRIIDFKRNKDDIPAKVASVEYDPNRTANIALLHYVDGEKRYIIAPKGLKVGEMIFSGPESDIKVGNALPLINIPVGTIIHNIEMKPGKGGQIARSAGNSAQLMAKEGRYALVRLPSGEVRQILIECRATIGQVGNLDHENVTIGKAGRKRKMGIRPTVRGSAMNPNDHPHGGGEGRSPIGRPSPVTPWGKPALGYKTRKKNKHSDKFIVTGRKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: GATM_DANRE
Sequence: MLRVRCLRGGSRGAEAAHLIGALVGRALSGRLSRASRSSSSSAAAQLPLSAHEQVPEPTAEECPVCAHNEWDPLEEVIVGRAENACVPPFTVEVKANTYEKYWPFYQQYGGQTFPKEHVQKAVAEIEEMCNILQHEGVTVRRPEPVDWSLEYRTPDFSSTGMYAAMPRDILMVVGNEIIEAPMAWRARFFEYRAYRPLIKEYFRRGARWTTAPKPTMADQLYDQDYPIRTVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGTDIFVQRSQVTNYMGIEWMRRHLSPTYKIHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCRQIEMFKKAGWTVVTPPTPLIPDNHPLWMSSKWLSMNVLMLDEKRVMVDANESTIQKMFESLGIKTVKVSIRHANSLGGGFHCWTTDVRRRGTLQSYFL
What is the function of this protein?
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.  Creatine plays a vital role in energy metabolism in muscle tissues.  May play a role in embryonic and central nervous system development (By similarity).
What are the official names of this protein?
Glycine amidinotransferase, mitochondrial, L-arginine:glycine amidinotransferase, Transamidinase.
What is the protein family that this protein belongs to?
Belongs to the amidinotransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: THIO_CHLTI
Sequence: AGKYFEATDKNFQTEILDSDKAVLVDFWASWCGPCMMLGPVIEQLADDYEGKAIIAKLNVDENPNIAGQYGIRSIPTMLIIKGGKVVDQMVGALPKNMIAKKIDEHIG
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: HCP_ECO57
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLAVDANARVDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECSMEIGQMNFKVMSILDAGETGKYGHPTPTQVNVKATAGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVRHLDGEDFSAVIAQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIFLLGGCDGARGERHYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFLTPDLLAVLNEKFGLRSITTVEEDMKQLLSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_LACDA
Sequence: MKHFIGNDWDHVLAPVFESGEYHKLHVFLKKEYQTRQIYPDMYHIFTAFKLTPFKDTKVVILGQDPYHNPSQANGMSFSVMPGTPLPPSLRNIYKELYDDVGAQPVNHGYLKRWADQGVLLLNAVLTVPYGQANGHQGKGWEMVTDAAIKALSERGQVVFILWGRFAQNKIPLIDQDKNVIIKSAHPSPFSANRGFFGSRPFSRCNAALKEFGRAPVDWQLPPNPEA
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL10_PAPHA
Sequence: MHSSALLCCLVVLTGVRASPGQGTQSENSCTRFPGNLPHMLRDLRDAFSRVKTFFQMKDQLDNILLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENHDPDIKEHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFSKLQEKGVYKAMSEFDIFINYIEAYMTMKIQN
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RK2_DRANE
Sequence: MAIHLYKTSTPSTRNGAVDSQVKSNPRNNLICGQHHCGKGRNARGIITVRHRGGGHKRLYRKIDFRRNAKDIYGRIVTIEYDPNRNAYICLIHYGDGEKRYILHPRGAIIGDTIVSGTEVPIKMGNALPLTDMPLGTAIHNIEITLGKGGQLARAAGAVAKLIAKEGKSATLKLPSGEVRLISKNCSATVGQVGNVGVNQKSLGRAGSKCWLGKRPVVRGVVMNPVDHPHGGGEGRAPIGRKKPVTPWGYPALGRRTRKRKKYSETLILRRRSK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL10_XANOM
Sequence: MALNLSQKQEVVAELADVAAKAHSLIAAEYAGTTVSQMTAMRKQARETGVFLKVVKNTLAARAVEGTDFAVAADKLVGPLLYAFSMEEPGAAGRLIKEFAKSNDKLQAKVVSIGGELFPAGHVDVLASLPTRDQALAMLARVLSEPAAMFARAVKAVGDKQGGGDAAAAAVAETAEA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: TPMT_SHEWM
Sequence: MEPDFWHSKWNAEQIGFHLNEVNPLLIKYWPALDLAPNSQVFVPLCGKSLDLCYLAELGHKVVGCELNQTAVEQFFAENSLPHLMTPAKESISELNRFDASDITLYQGDLFSLTPEELSGVDAFYDRAALIAWPESMRLAYVEKLIELLPPKSMGLLVTLDYPQEALKGPPFAVSNDWVMANMADYFELELLSSEDVLNENPRFVNKQVPWLTESVYQLKRRG
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y394_RUTMC
Sequence: MAGHSKWHNIQHRKGAQDAKRGKIFTKLIKEIVISAKIGGGRIENNHSLKIIIDKALAVNMRRNTIENAVKRGNGDFDGNNYEKIRYEGYSLGGTAIMVDCLSDNRNRTISDIRHAFLKHGGNLGRDGSVSYLFTKQGFISFDTGNENQIMEIALDEGAQDIITNDDDSIDVITTPEDFFTIKDVLTTSGLEPSHAEVTMEPASRVELNLSDAEKFMKLIDHLEDLDETKKIYHNADISDKVMVRL
What are the official names of this protein?
Probable transcriptional regulatory protein Rmag_0394.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOX3_MOUSE
Sequence: MYSLLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGGANAGNGGSGGANGGGGGGGGGGSDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPGGLLPPGAAAAAAAAAAAAAASSPVGVGQRLDTYTHVNGWANGAYSLVQEQLGYAQPPSMSSPPPPPALPQMHRYDMAGLQYSPMMPPGAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIASHSQRACLGDLRDMISMYLPPGGDAADAASPLPGGRLHGVHQHYQGAGTAVNGTVPLTHI
What is the function of this protein?
Transcription factor required during the formation of the hypothalamo-pituitary axis.  May function as a switch in neuronal development.  Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.  Required also within the pharyngeal epithelia for craniofacial morphogenesis.  Controls a genetic switch in male development.  Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
What are the official names of this protein?
Transcription factor SOX-3.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDTH_YERP3
Sequence: MALVSQARSLGKYFLLFDNLLVVLGFFVVFPLISIRFVDQLGWAALVVGLALGLRQLVQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFALMAMADEPWILWLACALSGLGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQYDFHFVCWTGAAIFVLAAGWNAWLLPAYRISTVRAPMKEGLMRVLRDRRFVTYVLTLTGYYMLAVQVMLMLPIVVNELAGSPAAVKWMYAIEAALSLTLLYPLARWSEKRFSLEQRLMAGLLIMTLSLFPIGMITHLQTLFMFICFFYMGSILAEPARETLGASLADSRARGSYMGFSRLGLALGGALGYTGGGWMYDTGKTLDMPELPWFLLGIIGLITLAGLYWQFNRRRIESAMLSSS
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MC148_MCV1
Sequence: MRGGDVFASVVLMLLLALPRPGVSLARRKCCLNPTNRPIPNPLLQDLSRVDYQAIGHDCGREAFRVTLQDGRQGCVSVGNKSLLDWLRGHKDLCPQIWSGCESL
What is the function of this protein?
Plays a role in antagonizing the chemotaxis of multiple leukocyte subsets induced by CC and CXC chemokines.  Displaces the interaction between CXCL12 and CXCR4 and thereby inactivates the antiviral activity of host CXCL12 (PubMed:21802105).
What are the official names of this protein?
Chemokine-like protein MC148.