PharMolix/UniProtQA huggingface dataset:
Protein: DALD_KLEPN
Sequence: MNNQFTWLHIGLGSFHRAHQAWYLHRLIASGDNRWRIAAGNIRNDAEQVVQALAAQGGRYVLETVSPEGEREYEEITSIQKLLPWQAGLQPLINEGANPQTKVIAFTVTEGGYYLNTRHRLETSNPDLQADLQGECKTIYGTLARILEKRMADNAGPLTLLNCDNVRHNGERFHDGMVEFLQLTGKQAVIDWMAANTTCPNTMVDRITPRPAADLPARIKAQAGIDDKAPVMGETFIQWVVENNFRDVRPNLEAVGVEMVESVIPYEEAKIRILNASHSCIAWAGTLIGQQYIHESTLTDVIYAIADRYVTEDVIPCLGDNGIDLPTYRDVVLKRFTNPYIQDTNQRVAADGFSKIPAMIAPTLQECYQRGVRPEATAMLPALFFVFMEQWHKGTLPYQYQDGILDAQAVHEMFEAQDPVAVFARDKALFGDLANNADFLALMREKVAAVYTLIN
What are the official names of this protein?
D-arabinitol 4-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: CYDC_ECOLI
Sequence: MRALLPYLALYKRHKWMLSLGIVLAIVTLLASIGLLTLSGWFLSASAVAGVAGLYSFNYMLPAAGVRGAAITRTAGRYFERLVSHDATFRVLQHLRIYTFSKLLPLSPAGLARYRQGELLNRVVADVDTLDHLYLRVISPLVGAFVVIMVVTIGLSFLDFTLAFTLGGIMLLTLFLMPPLFYRAGKSTGQNLTHLRGQYRQQLTAWLQGQAELTIFGASDRYRTQLENTEIQWLEAQRRQSELTALSQAIMLLIGALAVILMLWMASGGVGGNAQPGALIALFVFCALAAFEALAPVTGAFQHLGQVIASAVRISDLTDQKPEVTFPDTQTRVADRVSLTLRDVQFTYPEQSQQALKGISLQVNAGEHIAILGRTGCGKSTLLQQLTRAWDPQQGEILLNDSPIASLNEAALRQTISVVPQRVHLFSATLRDNLLLASPGSSDEALSEILRRVGLEKLLEDAGLNSWLGEGGRQLSGGELRRLAIARALLHDAPLVLLDEPTEGLDATTESQILELLAEMMREKTVLMVTHRLRGLSRFQQIIVMDNGQIIEQGTHAELLARQGRYYQFKQGL
What is the function of this protein?
Conversely, a more recent study suggests an alternative function of CydDC: authors suggest that CydDC does not mediate the export of L-cysteine but rather reduces cytoplasmic L-cystine to L-cysteine (PubMed:32900959).  The principle function of CydDC would be to maintain the reduced state of cytoplasmic L-cysteine, thereby providing an important connection between sulfur metabolism, oxidative stress and resistance to antibiotics (PubMed:32900959).
What are the official names of this protein?
Glutathione/L-cysteine transport system ATP-binding/permease protein CydC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3.A.1.129.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL31_SYNWW
Sequence: MKAKIHPKYHQAKARCACGNEFEVGSTSENIRVEICSKCHPFYTGAKGRLVDTTGRVDRFKKKYGLS
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: ZCHC3_MOUSE
Sequence: MATGGGAEEESQRGRPQLPLPARPVARVEEPEGVREKMGWAQVVKNLAEKKGDFREPRRRDETGSGASGGLGSPGGLATPNPGDFPPAARGDPKGRRRDPTGEASDAYRKKSASGAGDPSRRKKAEVTAAMATPARPGTTEDATERPLQDEPPAAGPGKGRFLVRICFQGDESACPTRDFVVGALILRSIGMDPDDIYAVIQIPGSREFDVSFRSAEKLALFLRVYEEKRELEDCWENFVVLGRSRSSLKTLFILFRNETVDVEDIVTWLKRHCDVLAVPVKVTDRFGIWTGEYKCEIELRQGEGGVRHLPGAFFLGAERGYSWYKGQPKTCFKCGSRTHMSGTCTQDRCFRCGEEGHLSPYCRKVIVCNLCGKRGHAFAQCPKAVHNSVTAQLTSVAGH
What is the function of this protein?
Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424).  Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424).  Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (By similarity).  Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (By similarity).  Promotes sensing of viral RNA by RIG-I-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (By similarity).
What are the official names of this protein?
Zinc finger CCHC domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_PARPJ
Sequence: MIGNWNYGTGRRKSAVARVFIKAGKGDIVVNGKPIADYFSRETSLMIVRQPLELTNHGVTFDIKVNVTGGGETGQAGAVRHGITRALMDYDATLKPELSKAGFVTRDAREVERKKVGFHKARRRKQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: NUOB_CHLPM
Sequence: MGLLDAAVSRQNVLVTSVDSVLNWARLSSLWPMGFGLACCAIEMMATNASNYDLERFGIFPRSSPRQSDLMIVAGTVTMKMAERVVRLYEQMPEPRYVLSMGSCSNCGGPYWEHGYHVLKGVDRVIPVDVYVPGCPPRPEALIGGLMKIQELIRMEGLGVSRADALKKLAEAESDPQPLIEEARKQKTA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GCSH_SHEWM
Sequence: MSNIPAELKYASSHEWIRKEEDGSYTVGISEHAQELLGDMVFVELPEVGDTLSAGEDCAVAESVKAASDIYAPLSGEVLAVNEALEDSPELVNSDAFGDGWFFRVMPSDVAEIDNLLDAEGYQAVIDEE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: SYGB_LACP3
Sequence: MTHQYLIEIGLEDMPAHVVTPSLQQFHDKTVAFLKENHLDHGAIDQYATPRRLALLIHDLADKQEDVEEDVKGPAKKIAQDADGNWTKAAIGFSRGQGMTPDDIVFKTIKGVDYVYLHKAIKGKTAAAILPGMLDVIKSLTFPTRMKWGAYDFEYIRPIHWLVSLLDDAIVPMKLLDVDAGRTTQGHRFLGRPVTLGNAADYVAALKAQFVIVEPAARKQLISDQIHQIAADHQWQIDLDADLLEEVNNLVEWPTAFAGNFDEKYLKIPEAVLITSMKDNQRYFYARDASGKMVNAFIGVRNGNADHLANVIAGNEKVLTARLEDAAFFYAEDQKRSIADDVDRLKAVSFHDKISSMYDKMARTRVIADLLADRFGLSATDKADLDRAASIYKFDLVTSMVGEFPELQGIMGEHYAQLAGEKPAVAQAIAEHYEPISADGALPESLVGTVLAIADKFDSLMSFFAVDLIPSGSNDPYALRRQAYGIVRMIAKHDWPFAVAELQTTIADALKAAGKTNNLDFAAHQQDLNAFMIDRAKQVLQGQKIRHDIVDAVTVRADADLAGILDAAKILSAHADDTDFKPVMEALGRVLRITKKQQVKVDVDTAKFENPSEGQLYDATVATAKKFDDEPTEADYQALKALADPINAYFDATMVMADDQAIRQNRLAALLQLAALIKQFGDVSQVIVK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_LISIN
Sequence: MANEMEFEKPILELKSKIADLKEYNETSDVDLTNEIEKLEKRLAKLEASIYSNMTAWDKFQVARHPERPTTLDYISLLFEDFMELHGDRTFGDDAAIVGGIATFKGTPVTVIGHQRGKDTKDNLHRNFGMPHPEGFRKALRLMKQADKFGRPIICFIDTKGAYPGRAAEERGQSEAIARNLYEMSDMKVPIISIVIGEGGSGGALALGLGNQIFMLENAVFSVISPEGAAAILWKDASLAKKAAESMRITAGDLYELGITDGIIPEVKGGAHRDLAAQAEEINKTITKSLHALMAFSEEQLIEQRYDKFKKIGVYETL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSV2_KLULA
Sequence: MLTRNPIVPENHVSNPIVDYEFNQDQSCLIVSTPKSFDIYNVHPLKRIMSQEMPDAGTIRMLHRTNYIAFVSTKKELLHIWDDVKKQDITRVKLDAAVKDLFLSREFIVVSQGDVISIFKFGNPWNKITEDIKFGGVCEFANGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDCKIAWISDTGLVIVWPNRRLADTFKLNYNDDEHVWWLQLNQRNEIPL
What is the function of this protein?
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
What are the official names of this protein?
SVP1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Vesicular and vacuolar.
Protein: ATPD_CLOBL
Sequence: MYEYLDRRYALALYEVAEENNKVDEYLRDLKEVVNIIKNSEDICKILKHPEINTSRKKEIFTELFKDKVDDKILSFLLVLIEKDRILYLEEKLKEMEKIYLEKNNMISANVKTVIPLLKEEREELIEKLGNKYNKKIILEEEIDKSIIGGVYVRVGDDVLDGTLSTRLKDIKKMMLKRE
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PRIB_PROMH
Sequence: MTANRLVLTGTVCKALIRKVSPAGIPHCQFVIEHRSTQEEAGLKRQSWCRMPIIASGKALQTDTHSITVGSKVTVSGFISSHQARNGLFKLVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: NOP19_YEAST
Sequence: MSRAKELQEKLNLQAKLQSTFSNNTAAVLDWLKESDETGISNDTERNKQLKDHKELEDGKKAFFKLPVLQIGSGLHFRTQDDASAKEDIHTIGEFIEGDKKVSSLAKKKKRSDPGLQRNNMYRITKDDTKAMIALKRKMRKGEKEGLRKKQEHSKSSVSNSYSASDEEDEDAGTMPQKSTKKKFGLLFDKKKKARK
What is the function of this protein?
Ribosome biogenesis factor required for cleavage of pre-rRNA at A0, A1 and A2 sites.  Essential for the incorporation of UTP25 in pre-ribosomes.
What are the official names of this protein?
Nucleolar protein 19.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TIM8_SCHPO
Sequence: MADATKNPIADLSESEQLELSKFIESEQQKVKLQQAIHQFTSTCWPKCIGNIGNKLDKSEEQCLQNCVERFLDCNFHIIKRYALEKFGFLFCWLGFSC
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim8.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: CUX1_RAT
Sequence: MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDPVPALDLGQQLEIKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEDVKKELTTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGSARRKGRDQPESRRPGPLPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPDVNGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQASSTASSGNSDDAIRSILQQARREMEAQQAALDPALKPAPLSQPDLTILNPKLLSASPMSTVSTYPPLAISLKKTPAAPEASTSALPSAPALKKEAQDAPTLDPPGSADATPGVLRPVKNELVRGSTWKDPWWNPVQPERRNLTTSEETKADETNASGKEKTGSSQPRAERSQLQGPSATAEYWKEWPNAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPTIETSKEGKPPEPSDPPTSDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVEAADTEEPGGNIVATKSQGGPAEVTAAPADREEATQPAEKAKAQPLSSGTPGQDDGEDAGRSRPPPEGLADAPAPVPNLAAPAAGEDAATSATAPAMATEAPGAARAGPAERSSALPSTSAPANAPARRPSSLQSLFGLPEAAGARDNPVRKKKAANLNSIIHRLEKAASREEPIEWEF
What is the function of this protein?
Plays a role in cell cycle progression, in particular at the G1/S transition.  As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa.  While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.
What are the official names of this protein?
Homeobox protein cut-like 1, CCAAT displacement protein, CDP, CDP2, Homeobox protein cux-1.
What is the protein family that this protein belongs to?
Belongs to the CUT homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAL_PASMU
Sequence: MKKLTKVLLVAGSVAVLAACGSSKKDESAGQMFGGYSVQDLQQRYNTVYFGFDKYNIEGEYVQILDAHAAFLNATPATKVVVEGNTDERGTPEYNIALGQRRADAVKHYLSAKGVQAGQVSTVSYGEEKPAVLGHDEAAYSKNRRAVLAY
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Peptidoglycan-associated lipoprotein, PAL, Outer membrane protein P6, OMP P6, P6-like.
What is the protein family that this protein belongs to?
Belongs to the Pal lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RS2_HAES1
Sequence: MAQVSMRDMLQAGVHFGHQTRYWNPKMKPFIFGPRNGVHIINLEKTVPMFNEALVELTRIASNNGRILFVGTKRAASEVVKAAALDCQQYYVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALVRTREMEKLELSLGGIKDMGGLPDAIFVIGADHEHIAIKEANNLGIPVFAIVDTNSSPDGVDFVIPGNDDASRAIQLYLSAATTAVKEGRNQETVTEEVFAAAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RRF_GLOC7
Sequence: MKLSEVQDNMQKTIESTQRSFNTIRTGRANSALLDRVMVDYYGTETPLKSLANITTPDATTIAIQPYDRGSMGQIEKAIQLSDIGLTPNNDGQMIRLNIPPLTTERRKELVKLAGKLAEEGKVAIRNIRRDAIDSVRKQEKNHELSEDESRNLQDEIQKVTDEYTAKIDELLAAKEKDISTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAN3_XENTR
Sequence: MNSGLTPSPSPAVAAAGPAGVPGSKLKFCRYYAKDRTCFYGDECQFLHDDQLGGIHGNGNSPLSLPGGGPAAVYPQPVTPVGSKKLDLAGLEAQRLAIPGLDGGAIPDTSLTDSYFSTSFIGLNGFGSPGEATYPRMQQRMTNSSSSPSLLNDSAKPYAAHDPLGSPASAMFNDFGGLTMSQRRKTPNPTASEFIPKGGSTSRLSNMSQSSMSAFSQALFSHPSMGGPTGAGLAPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPANYMVPTSASTPVTNSVSQPPSTGEIIQKATVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHIAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPGVPAEVDSYHSLFPLEPLPPPNRIKTSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMSLVDTWKKIQHSNIVTLREMFTTKAFGEHSLVFAYDFHAGSETMMSRHFNDPSADAYFTKRKWGQHDGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGIFDVLTYDGSQNNPVALMPQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTEQNRMRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPAWSETGDRYLLKLFRDHLFHQVTEAGTPWIDLSHIVSCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELVAAANGQL
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP).  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit pan3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm, P-body.
Protein: VPS53_CAEEL
Sequence: MEEPTTSELKLSDNVMNEISDMCITEYCKPNMSLMAQINELFPTEQSLTQLDSIIASVEGEIGELDNELAYLVETNANVSERGEEALKHAQDAMIELEKSIGSIRERTKSSDEIVREMTRDIKQLDIAKRNLTASITTLHHLHILLTGVESLGAWVDKKDYSSIARQLPAILNVLQLFDAYKESDQIANLSGQLDKLKASLTIQLAKDLKNAFQTGQLSDRITDMCRVAAALEGNVKENFVKWFIEQQLSEYVIIYADNEEGAWLDKVDDRYKWFVRKLTDFERAGLSNIFPADWHMGRRLTSEFCTVTRDILYRIMTRRRQDLDWKLLGHAIQHTKMFEALLTKRFPEKDGISFEKAIWSVFDTFLDVFINAQEKTLNEFLDTCASKIRSGEEKPSRESSTHAVPFPSSADMFLLLKKVITESSKLSSEPDALIRDVIGVVRVCLRGYATSCLVAFLPSLGSQQSGAANLFSLIREEIAYPRLTPDQQFLVCCILATADWCAETSIQLQEKLSQRIPGVDISQETEAFYSITNQSLQVLVQDVESTCDAALQSISKVNWTAVDCVGDESPFIGSMRAHLRQAVPLIRDMLSDRRKYFAHFCLKLATQLAHKFVGSLFRCRTISTHGAEQLLLDTHSLKTFLLSVPSIDSIINSKPPTAYVTSVNAALTKAEMILKVVMCSLETVDEFVEQYIKLLPASDAAEMQKVLEMKGVKRQEHSAVLNAYRLKIGASGSDPIQQSNSLTSRIGGALPTVGSAASVSEAFNAVVSMAADGLSDQAVTSSIDKLKRFERLVKRQL
What is the function of this protein?
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545).  The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545).  Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843).  Important for neuronal function (PubMed:27191843).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 53 homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS53 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Perikaryon. Cytoplasm, perinuclear region. Note=Co-localizes with rab-2 to perinuclear puncta in the perikaryon.
Protein: SECA_CAMFF
Sequence: MITAIAKKIFGTRNDKEIKKYFKRVALINALEGKYSNLSDDELKSEFSKLKVDLLSKKVTKDDILNDVFAIVREVSKRTLNMRHFDVQLIGGMVLNDGRIAEMKTGEGKTLVATLPVVLNAMDEKGVHVVTVNDYLAKRDATQMSEIYNFLGLSVGVILSGEYDDEKRKIAYNSDITYGTNNEFGFDYLRDNMKFEVGQKVQREHNFVIVDEVDSILIDEARTPLIISGPTNRTLDGYIQADVVAKQLVRGEAADPRVPNSKATGDFVVDEKNRTIMITEAGIAKAEKLFGVDNLYNLENAILSHHLDQALKAHNLFEKDVHYVVRDSQVIIVDEFTGRLSEGRRFSEGLHQALEAKEGVKIQEESQTLADITFQNYFRMYSRLSGMTGTAQTEATEFSQIYKLEVISIPTNVPIKRVDRDDLIYKTENEKFKAVIEEIKRSNIKGQPVLVGTASIEKSEIFHKMLVKEKIAHSVLNAKNHEKEAEIIAQAGAKGAVTIATNMAGRGVDIRIDDEVRELGGLYIIGTERHESRRIDNQLRGRAGRQGDPGLSRFYLSLEDSLLRIFGSDKIKAIMDRLGIEEGESIESRLVTRAVENAQKKVESLHFESRKHILEYDDVANEQRKTVYKYRDELLNPDYDLKDKIISNRQDFVKTLLDEVNIFDGGLGDEFDISRLCEVVYGESGTKIDEDEIKGLDYHSLADKVIDKLAKDYDEKMSVIDDEQRKNIEKVLYLQVLDGAWREHLYQMDILKTGIGLRGYNQKDPLTEYKKESYNLFMELVNRLKNESIKTLQIVRFKTEDDENTDRALEKMQDEANLQNKFEKKPARNEPCPCGSGKKYKDCCGKSGPKKGVFA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ATG26_GIBZE
Sequence: MATQADDAAASQANIEDGDLKEHVHDELDKIQQQRSTATVFPEPLRESDSEDSDDEDNGPAQAPPMFMNMNQSIYGLIAQASNRVDFNDRFDGMSSDEEGESSQNTRTESIARTSILQPAGKGKDKVHRRRKLSEHKLLRSLPALPKLRSRHKSQHSTLPAPEEVADEADDEHGDGGLLPAPALTLTRQDTQDRLAPVMSRMLEAKADLSIRPSFDLDRLSSDVSRSSDSDEVSALSRKLKEIFEFDEYEQVIEEYPCWLLQSVLLQGYMYITSKHICFYAYLPKKTHEAVKSGYLSKSGKRNPSYARFWFRLKGDVLTYYKTATDVYFPHGQIDLRYGISASIVDTDKEALHFVVETRHRTYKFKADSAPSAKEWVKSLQRVIFRSHNDGDSVKISLPIKNVMDIEDTQMISFADTCKIRVIDNDETYAIDEYFFSFFSFGKEAINVLKILIEDSSGARSAEQVITGDDHDSSQPSSGHASKAASKRAPSKLSTGKLPDTVKATLAPMSPLSPRSPSQLSPRASMDAPRSSFDGFRRFGKKSLDVTSSIGDHSPRRSFSGRRSTSHQHRQGTTTPKQAHDSEDSFLQSSIENPSISTLSPSSYDEPSASQILQGSDVFHSPMMRRSASTSRKRDRSGKRTPRSSSAHGDRHHGIPHAATTGAIHKMGDEQADSQRPATPTLNSITKIGAYPLQRANAFAEYLSRTSQRMGSMFATESLGYVEKVHGMWKGEHRHYDEPQELRTDDDGEDIDSEADDKMQTTIDRFRAHFALPESEKLVATYFGAIFKVLPLYGKFYISDRSFCFRSLYPGTRTKLILPLKDIENVHKEKGFRYGYYGLTVVIRGHEELFFEFRKPGLRDDCAVTLHQLMETNRFLEQSGILDQEEQDDEEAAAAMAERDELQEARQDEFVDHELTLPRTTSGVSNAPTILFDNPNSSGLAFKPQKSMKITCLTIGSRGDIQPYIALCKGLLAEGHKPRIATHGEFQEWVESHGIEFARVEGDPGELMRLCIENGTFTWAFLREANSTFRGWLDDLLDSAYTACEGSELLIESPSAMAGIHIAEKLEIPYFRAFTMPWTRTRAYPHAFIMPEHKMGGAFNYMTYVMFDNIFWKATAYQVNRWRNKTLGLPSTSLEKMQPNKVPFLYNFSPSVVAPPLDFSDWIRVTGYWFLNEGGGDWKPPQELQDFIAKARADGKKIVYVGFGSIIVKDPAKMTQEVIDAVLKADVRCILSKGWSDRISPKDDPSKPPPDEPVIPAEIHVITSAPHDWLFSQIDAAAHHGGSGTTGASLRAGIPTIIRPFFGDQFFFSTRVEDLGVGVCVRKWGTNSFGRALWEVTRNERMIVKARVLGEQIRSESGVDNAIQCIYRDLEYAKSLIKRRAGKNNAEHGLAEDDDDTEESWTFVGRDEPDPDAVTKKLSDGLAGLGAAGDRPPPLGSQAPTVA
What is the function of this protein?
Probable sterol 3-beta-glucosyltransferase that mediates autophagic degradation of peroxisomes (pexophagy) (By similarity).  Also required for cytoplasm to vacuole transport (Cvt) and autophagic degradation of mitochondria (mitophagy) and nuclei (nucleophagy) (By similarity).
What are the official names of this protein?
Sterol 3-beta-glucosyltransferase ATG26, Autophagy-related protein 26.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.