Protein: PREU3_PREIS
Sequence: MNPPSALAFGPEERIPTASNLRLLKDVLQDDPTFAGITACLKQLPDTWKALLHQDAQLQSLASERRAAVLSNSLLNDEQHEGDMDTNQVIMPMTVLVHMVQYRQFLQQSSPSSHATVMQSVAAGGVQGFCAGLLSAFAVCSMTNEDDFDACATYAIKLAMCVGAYVDLAMESEKGDMASAIVRWSIPDGRNRVNKAVGRYQSAYISAISDEDNVTVTASRPDLDAICTSLGSTGMSSKILAMTGSFHHPKNFDLLQRMISLLRAPQLAPSTKFTNALLRSNSTGELLTGAKTIENILEDILCKTADWRLTMANTSKALRSGNGSRPNIHTFGLVEFIPSFVKNEFNILTQRLAPTAKEQTGASPSKSTLQYNDNAVAVVGMACRFPGADDLDEFWELLQSGKSMHERMPADRFSTTGLRRSNDGAPFWGNFLKDIDAFDHQFFKKSSREAAAMDPQQRLLLQCAYVAMENAGYFDPSVQHKIRDTGVYLGACSSDYNDNVASHKPTAYSTLGTLRAFLTGRISHYFDWTGPSVVYDTACSSSAVAIDAACKAILAGDCQQALAGGVSLYTSPNFYQNLDAASFLSQTGPCKPFDANADGYCRGEGVGLVVLKKLSDAIRCGDKIVAVIASTGVNQNRNCTGITVPHGGSQADLYRRVVAKSGLNASQVSYVEAHGTGTPVGDPIEFTSIKSVFANPDITRDEPLTIASVKGSIGHLEGAAGVASLIKVCLMLQHSAIPPQANFTKPNPNLGGVDMRNIVIPTSSIPWKARNKVACINNYGAAGSNGAMIVCQPSEPASKTQTRLPSQSLSYPLFISGDGTDAVEANCRAIAKYARQLQQKRAPSVVASLAYRLATSQNQNLSYAMVTTISENGDIESTLTKASATLTQPRSKAKQSVVLCFGGQVKAFVGLDQQLFDSSSILQKHLRLCDSTMRDLGYPSIFPAIFQSEPLKDPVQLHGVLFAMQYSSAKAWLDCSLQVDAVVGHSFGQLTALTVAGVLSLKDGLRLVCGRAHLIKTKWGSATGAMIAIEAPLIRVQEILSKISVAGHEAEIACYNARESHVLVGTTTAIDAVRTFVLESGIKHKRLPVTHGFHSTFTEALLPGLRELAKGLQFKSPIIPIETCTEYKSWEQATADMITKHTREPVYFVHAIERLSARLGPCTWVEAGTGASTPAMIKRCLPDSCADSFIHATLESNKAFGSLADATANLWRCSQPVQFWPFHASDRGRYVPLNLPGYQFRKTKHWLEWQDTVALPAFLEKEPSTSEPKGHELLTFSSFEDTSKSVAAFKVDPESDEFMMLVKGHAVVAQPLCPAPLYCELALRAIKHLSPETASNAPDIRDLQIHAPLGLKTNRNIRLVVQKNSIPGHWTFTVKSSMGSDDELTHAHGLVAFGGTVEQELASYQRLIGHQKIQSLMTDPECDALRGSATYKAFNRVVTYSSYYKGVQAIYGRQNEACGKIELSSGEEQMAQARGILTPLLADNFIQIAGLQINVLGDCEDHLVFVCTETQRIIYGPGLHQQPAARYEVYSTISQNGPKEVMSDVVVFDPATKNVEFVALGCRFTRVTVPGLRNALQAANGDARAQERPSGSRISPSPLAPELPAKIQIQSRENLDITEKSGRGKPPRVENIQIATPKVDYLAQVKALLHKVSDVPIDTIQKDSTLDDLGIDSLMVMEVQTEVHSEFQLTIPNKDWATLETPGKLAEYLAKTLGGSVPDSAPPGVQRVPALVISDAEQSSDESPYDSTDDSASGYGDLDIDTAATTPGIFATRDSSPFRKAALDSPNPVNKVAQRTFSDIRPKYDVFAAEEGFAGFWRDVYPRQKRLTLAYVVEAFAVMGCDLSDLAAGQILPKIEYLPQHVSLIKQLYVILADSTLITIENGTYRRTRVSVDTTPASDLLADILRAFPQHAEEHRLLDVTGSRLGDCLIGRADPLRLLFMDRANKELLDSVYANGPMYKAMSRLLGSYILDTMQQWQGQKPLRILEIGGGTGGTTKHIVKLLHQQGIDFTYCFSDLSRALVTKAKKTFSIYPQMEYMVLDIEAPPSSEYLGQFDLILSTNCIHATKNIQQTTKHMRQLLSSEGFICLVEFTRNIFWFDLVFGLLDGWWLFEDGRPHVLADENLWDQSLRAAGYGDVQWTEGQSEESKTLRLIAAFNVSNEDAKAANALASALAVPGRKGRTSATTIRWKQEGDLDLMADVYLPSDLDASTVSRPVALILHGGGHVLHTRKHINPRHIKMLQDLGFLPVSVDYRLCPEVNIRDGPMTDACEAVDWARNILPCLPVCSELRVDKEHVVVIGYSTGGHLALTTAFTTRVRGFKPPSAILGFYCPTNYSADWWRSPIYPELAQQSSSETFDLLEGVNEHAIAGYTPTVNNNVAALLMSLDDPRWRFVLHANWRAQTLPMLINGLPSKSRLARSGQTVDSVINREIPDAEDVASISPYDQIVRGSYSTPTFLLHGTKDDLIPWQQSIATVDALARRGVNARVEIIEGAEHCFDVWSDKYDGMIGRALEWLVEQCRNA
What is the function of this protein?
Non-reducing polyketide synthase; part of a gene cluster that mediates the biosynthesis of a yet unidentified natural product (Probable).  The first step in the pathway is performed by Preu3 that condenses one acetyl-CoA starter unit with 3 malonyl-CoA units (PubMed:35602042).  Preu3 also catalyzes one methylation step to produce 3-methylorsellinate, an intermediate that exhibits significant antibacterial activities against methicillin-resistant Staphylococcus aureus, multidrug-resistant Enterococcus faecalis, multidrug-resistant Enterococcus faecium, and multidrug-resistant Staphylococcus epidermidis (PubMed:35602042).
What are the official names of this protein?
Non-reducing polyketide synthase Preu3, NR-PKS Preu3, 3-methylorsellinate synthase.