PharMolix/UniProtQA huggingface dataset:
Protein: GPMI_FRATH
Sequence: MKKTTLLVILDGWGYSDSDYFNAIKNANTPTWDSIWQEFPKTLINASSLEVGLPRSQMGNSEVGHVNIGCGRVVYQELTKIDKAIEEKTFGDNKAICAAIDNVIKNDSNLHLIGLLSPGGVHSHEEHIFEMIKIAKQKGIKRLYLHAFLDGRDTPPRSAEKSIKKADKLLQDLNLGYIASVCGRYYAMDRDNRWDRVEKAYNAIVNANADFIYDSALEALEQSYARDQSDEFVIPTCIKKDGHLVKVQDNDSVIFMNFRADRAREISHAFTDESFDHFPRKKHLNINFTTLTEYDSKLKCAVAFPPEQPINTLGEVLMKNHKTQLRIAETEKYPHVTFFFNGGREEQFEGEDRILIPSPKVATYDLQPEMSAPEVTDKLVAAINSGKYDCIVCNYANSDMVGHTGNYEAAMQAIEYLDKCIARLKDAILEHDGNMFITADHGNADMMVNPETQKPHTAHTTNLVPFIYVGHKKAQVALEHGKLSDIAPTLLNVMGIAQPKEMTGKTIFNFEK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: SYY_AERHH
Sequence: MINPHLLDELTRRGLVAQNSDPVALADHLATPRTVYCGFDPTAGSLHIGHLVPLLMLRRFQLAGHTPVALVGGATGLIGDPSFKATERNLNSSETVQGWVASLSAQIKALLPASEGLAAPLLVNNADWMGQMSALDFLRDIGKHFSVNAMLVRESVRQRLARPDQGISFTEFSYALLQSQDYAVLNQRLGCTLQIGGNDQWGNITSGMDLTRRLHQAQVYGMTLPLITKADGTKFGKTEGGAIWLDPALTSPYAFYQFWLGTADEDVYRFLRYYSFMPLTEIEALEAEDAKRQGRKLAQQVLADELTELVHGKGALAAAQRISELLFSGEVARLGESDLAQLAQDGMPGWRIEGETDLVTLLVESGLANSKRIARELLAAGAISLNGEIRREEPLRAADRLFGRHLLLRRGKKQYRLVTWQG
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECX_STRZP
Sequence: MKITKLEKKKRLYLMELDGQQTSYITEDTIVRFMLSRDKVISKEELTEIQDFAQFSYGKNLALYHLSFKARTEKEVREYLKKYDIDKNIVSQVIANLKEDKWINDGQYAYAIINTNQLSGDKGPYVLTQKLAQKGISKSTIEENLKEFDFSEVAQRVANKLLKKYEGKLPSRALQDKIIQNLTNKGFSYSDAKIAFDDLDSQVDQETTQELIFKELDKQYSKYARKYEGYELKQRLTQVLARKGYDFSDIASALREYL
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPB1_STAAM
Sequence: MAETTKIFESHLVKQALKDSVLKLYPVYMIKNPIMFVVEVGMLLALGLTIYPDLFHQESVSRLYVFSIFIILLLTLVFANFSEALAEGRGKAQANALRQTQTEMKARRIKQDGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGLATVDESAITGESAPVIKESGGDFDNVIGGTSVASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNEIALFTLLMTLTIIFLVVILTMYPLAKFLNFNLSIAMLIALAVCLIPTTIGGLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTITYGNRMADAFIPVKSSSFERLVKAAYESSIADDTPEGRSIVKLAYKQHIDLPQEVGEYIPFTAETRMSGVKFTTREVYKGAPNSMVKRVKEAGGHIPVDLDALVKGVSKKGGTPLVVLEDNEILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVDRFVAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAMNSGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDIAKYFAILPAMFMAAMPAMNHLNIMHLHSPESAVLSALIFNALIIVLLIPIAMKGVKFKGASTQTILMKNMLVYGLGGMIVPFIGIKLIDLIIQLFV
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit 1, ATP phosphohydrolase [potassium-transporting] B chain 1, Potassium-binding and translocating subunit B 1, Potassium-translocating ATPase B chain 1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEU3_BLAAD
Sequence: MSKNIIILSGDHVGPEVTAEAIKVLEAITQARPNVKFNFDHKLIGGAAIDATGSPLPDETLEASKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFMSEKLLDLSPLRSEIVKGTNFTVVRELVGGIYFGTRKEDEGNGEAWDTEKYTVEEVKRITRMAAFLALQSNPPLPVWSLDKANVLASSRLWRKTVTETIEKEFPQLTLNHQLIDSAAMILIQNPSKMNGVIVTSNMFGDIISDEASVIPGSLGLLPSASLSSLPDKNTAFGLYEPCHGSAPDLPPNKVNPIATILSAAMMLRLSLNLKEEADAVEKAVSKVIDNGIVTADLKGASSTTEVGDAVAAEVQKLLK
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, IMDH, Beta-IPM dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RD24_PHYIT
Sequence: MHSSLLWLGAVVALLAVNNVTAVSTEANGQVALSTSKGQLAGERAEEENSIVRSLRAVETSEDEEERDLLGLFAKSKLKKMMKSESFKLKRFGEWDDFTVGYIREKLKNKYPDLLLNYLNVYKKAGNEIVRHANNPNKVTFSNKVRARIYKTNS
What is the function of this protein?
Effector that interacts with isoforms of host protein phosphatase type 1c (PP1c), mimicking a regulatory subunit and causing their re-localization within the host nucleus (PubMed:26822079).  The holoenzymes formed with PP1c isoforms act to promote late blight by attenuating jasmonic acid (JA)- and salicylic acid (SA)-mediated transcriptional responses of the host plant (PubMed:26822079).
What are the official names of this protein?
RxLR effector protein PexRD24.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus, host nucleoplasm. Host nucleus, host nucleolus.
Protein: ZIP5_ORYSJ
Sequence: MATAAMTKVFVLLFLVAACYLPAHAAAAECDCATDTAGRDKAQALRLKVIAIFCILAGSTVGAALPSLGGRFPAIQPETDVFLSVKAFAGGVILATGLVHILPAAFEALSSPCLVGGPWKRFPFAGMVAMVSAIGTLIVDTVATGYFHRTDAKRKAAAVADEPADDLEASDEHSHGHAHGMSVMSVAPAGEEDLVRHRVISQVLELGVVVHSLIIGMSLGASDFPSTVRPLVPALTFHQFFEGIGLGGCIVQAKFRVRSVVTMALFFSLTTPAGIVVGIGISSVYDANSPTALVVQGLLEAAAAGILVYMALVDILAEDFMKTKVQRRGRLQLAMNVALLLGAGLMSMIAIWA
What is the function of this protein?
Zinc transporter that mediates zinc uptake from the rhizosphere and may be responsible for the translocation of zinc within the plant.
What are the official names of this protein?
Zinc transporter 5, ZRT/IRT-like protein 5, OsZIP5.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS8_THEP3
Sequence: MIENLVREEIKGFKNYEVHSIPYRYKMDANETPFELPEEVIKNIQEIVKSSQVNVYPDPTAEKLKEELARYCGVVPTNIFVGNGSDEIIHLIMLAFINKGDVVAYPHPSFAMYSVYSKIAGAVEIPVRLREDYNYDVDSFIKVIEKYQPKLVFLCNPNNPTGSVIEREDIIKIIQKSNGIVVVDEAYFEFYGNTIVDVINEFENLIVLRTLSKAFGLAGLRVGYAVANENILKYLNLVKSPYNINSLSQVIALKVLRTGVLKERVNFILKERERLIKELSKIPGIKVYPSKTNFILVKFKDADYVYQGLLERGILVRDFSKVEGLEGALRITVSSCEANDYLINGLKELLL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: GLMU_SYNS3
Sequence: MLAVAVLAAGKGTRMKSALPKVLQPLAGATLVERVLASARNLAPERRLLIVGHQAERVEAQLSSNGGLEFVLQQPQNGTGHAVQQLLAPLQGFQGELLVLNGDVPLLRAETIEALVSTHRSSQADVTLLTARLDDPTGYGRVFADANGRVSAIIEHRDCSDEQRSNNLTNAGIYCFNWGKLAEVLPQLSTDNDQGELYLTDTVQLLDVAMQMEVSDPDEVNGINNRRQLAQCEGVLQQRLRDHWMDEGVTFVDPASCTLSEDCSFGCDVVIEPQTHLRGACRIGDNCRLGPGSLLDNAELGCDVTVVQSVVRDARVGNDVAIGPFAHIRPATDVGDSCKIGNFVEIKKSVIAAGSKVNHLSYIGDAELGANVNVGAGTITANFDGTNKHLTVIGEGSKTGANSVLVAPVVIGKNVTIGAGSTITKAVPDGSLAIGRAKQLTKEGWDRNTQAAQS
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_STRAW
Sequence: MSTIDILSPSGDNAGTVELPAEIFDVEKISIPLLHQVVVAQLAAARQGTHKVKRRGEVRGGGKKPYRQKGTGRARQGSTRAPQFAGGGVVHGPTPRDYSQRTPKKMKAAALRHALTDRARNARIHVITGVIEGETPSTKAAKSFLGKVSERKNVLLVIERSDEAALLSARNLPQVHILEPGQLNTYDVLVSDDVVFTQAAFESFVSGAPQSSAADTEGSEA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: GP63_LEIMA
Sequence: MSVDSSSTHRRRCVAARLVRLAAAGAAVTVAVGTAAAWAHAGALQHRCVHDAMQARVRQSVADHHKAPGAVSAVGLPYVTLDAAHTAAAADPRPGSARSVVRDVNWGALRIAVSTEDLTDPAYHCARVGQHVKDHAGAIVTCTAEDILTNEKRDILVKHLIPQAVQLHTERLKVQQVQGKWKVTDMVGDICGDFKVPQAHITEGFSNTDFVMYVASVPSEEGVLAWATTCQTFSDGHPAVGVINIPAANIASRYDQLVTRVVTHEMAHALGFSGPFFEDARIVANVPNVRGKNFDVPVINSSTAVAKAREQYGCDTLEYLEVEDQGGAGSAGSHIKMRNAQDELMAPAAAAGYYTALTMAIFQDLGFYQADFSKAEVMPWGQNAGCAFLTNKCMEQSVTQWPAMFCNESEDAIRCPTSRLSLGACGVTRHPGLPPYWQYFTDPSLAGVSAFMDYCPVVVPYSDGSCTQRASEAHASLLPFNVFSDAARCIDGAFRPKATDGIVKSYAGLCANVQCDTATRTYSVQVHGSNDYTNCTPGLRVELSTVSNAFEGGGYITCPPYVEVCQGNVQAAKDGGNTAAGRRGPRAAATALLVAALLAVAL
What is the function of this protein?
Has an integral role during the infection of macrophages in the mammalian host.
What are the official names of this protein?
Leishmanolysin, Cell surface protease, Major surface glycoprotein, Major surface protease, Promastigote surface endopeptidase, Protein gp63.
What is the protein family that this protein belongs to?
Belongs to the peptidase M8 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: TRI36_HUMAN
Sequence: MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKELLLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
What is the function of this protein?
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.  Involved in chromosome segregation and cell cycle regulation (PubMed:28087737).  May play a role in the acrosome reaction and fertilization.
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM36, RING finger protein 98, RING-type E3 ubiquitin transferase TRIM36, Tripartite motif-containing protein 36, Zinc-binding protein Rbcc728.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Found in the acrosomal region of elongated spermatids and mature sperm.
Protein: CRYGS_CYPCA
Sequence: MGRIIFYEDKNFQGRRYECDSDCSDFHAFLNRCNSIRVESGAWVIYERPNFMGYQYVLTRGEYPDYQRWMGLNDRLCSCKMIHFVSGSEYKIQLYDKGDFTGQVYESTEDCPSVVDRFRTREVHSCKVLDGIWIFYEHPNYRGRQYLLEKGEYRKPVDWGAVCPTVQSFKRLME
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Gamma-crystallin S, Beta-crystallin S, Gamma-S-crystallin.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: RU17_ARATH
Sequence: MGDSGDPFLRNPNAAVQARAKVQNRANVLQLKLMGQSHPTGLTNNLLKLFEPRPPLEYKPPPEKRKCPPYTGMAQFVSNFAEPGDPEYAPPKPEVELPSQKRERIHKLRLEKGVEKAAEDLKKYDPNNDPNATGDPYKTLFVSRLNYESSESKIKREFESYGPIKRVHLVTDQLTNKPKGYAFIEYMHTRDMKAAYKQADGQKIDGRRVLVDVERGRTVPNWRPRRLGGGLGTSRVGGGEEIVGEQQPQGRTSQSEEPSRPREEREKSREKGKERERSRELSHEQPRERSRDRPREDKHHRDRDQGGRDRDRDSRRDRDRTRDRGDRDRRDRDRGRDRTSRDHDRDRSRKKERDYEGGEYEHEGGGRSRERDAEYRGEPEETRGYYEDDQGDTDRYSHRYDKMEEDDFRYEREYKRSKRSESREYVR
What is the function of this protein?
Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA.
What are the official names of this protein?
U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, U1-70K, snRNP70.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm. Note=The exchange between speckles and nucleoplasm is sensitive to ongoing transcription and phosphorylation.
Protein: COAD_CHLPB
Sequence: MERLAIYPGTFDPFTNGHLDVLERALTIFDKVYIVLAENSKKSSLFTVDERCSMIREITASTSGVSVEVLHGGLLAEYAHSVGATAIVRGLRQVKDFEYEFQLSLLNRHLNPEVTTVFLMPNVKYTYVASSIIREVALLGGDVSKFVHPCVLAMLKKKYEEQNAQ
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PT3_BOVIN
Sequence: MRSSLAPGIWYRAFILLITFLIYTCYHMSRKPISVVKSRLHHNCSEVIQPVNSTHSLNDTTWCNWAPFDKSNYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLTAGMLLSGLFTSLFGLGYFWNIHVLWYFVLVQIFNGLVQTTGWPAVVSCVGNWFGKGKRGLIMGIWNSHTSVGNILGSLLAGVWVDQQWGLSFVVPGVITAIMGIITFFFLIEYPEDVDCSPPQHHGNPEESQDQPEDPANGPSCNKESSLESAVTCSKEASAQPSAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYISNVVHFTAKEAGDLSTLFDVGGIIGGILAGLVSDYINGRATTCCVMLILAAPMMFLYNHVGQRGIGISIVMLLICGALVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLIAADVLACLLLCRLVYKEILAWKSSLSKDRGYREM
What is the function of this protein?
Inorganic phosphate and glucose-6-phosphate antiporter.  May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction.  Independent of a lumenal glucose-6-phosphatase.  May not play a role in homeostatic regulation of blood glucose levels.
What are the official names of this protein?
Glucose-6-phosphate exchanger SLC37A2, Solute carrier family 37 member 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ERPA_GLAP5
Sequence: MSDILVPLIFTDAAAKKVKFLIEGEENPELRLRVYITGGGCSGFQYGFTFDDKLNEGDLTIENLDVALVIDPMSLQYLIGATIDYVEGLDGSRFVVQNPNASSTCGCGASFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: DHYS_DICDI
Sequence: MSTNTTTTNATPELAKESVFFQSNHEDLKNRPKVRGYDFNEGVDFSKLFETYKTIGYQASAVGEAIDEINRMISWRLVDEPLKEGEDDDEERKVTRCKIFLGYTSNLVSSGVREIIRYLVQHSMVDVIVSTAGGVEEDFIKCLAPTYMGEFHLEGEKLRRKGLNRIGNLLVPNDNYCKFEDWIMPILDQMVEEQKTKGTVWTPSRVINRLGKEINHEDSIYYWAWKNDIPVYSPALTDGSIGDMMYFHSYNTPGLVLDIISDIRAINNHAVYSKKSGMIILGGGVIKHHICNANLFRNGADYSVFVNTGNEFDGSDSGARPDEAVSWGKIKLDAKPVKVYSEASIVFPILVAETFAKTFKKKSPEELKLNKRSIFD
What is the function of this protein?
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.  This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine.  Hypusination is unique to mature eIF-5A factor and is essential for its function.
What are the official names of this protein?
Probable deoxyhypusine synthase, DHS.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: PA_I02A1
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIENPSHEGEGIPLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLVWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCKDVSDLKQYDSDEPEPRSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFESKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRRLLLIVQALGDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: C3H1_ORYSJ
Sequence: MAGRGGMVEWEVGRRRDSEDVIVLSPGPPARRRPPPVKAVEPESGGFAYEPPEKLFYKTRVCETFVTSGRCMFEDGCTFAHGDEELRPSLTACAGGWRKPSPSLSAAAPPVAVAPTPPPAQVVHELLARGSGSGGGGHRAITKVCFEFRDKGICYFGETCAFPHVSAAEIRQGSRLSSMSSSSWEMPARRSVAVTVPRTFVSVPPVAPPPPPPHYRVNNSSSYNAASMAAAAPAASDANLVAQQPPPEQGGRKMTRLEMLSLKKMTGIYGDWLEGYEHP
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 1, OsC3H1.
Protein: ENO_POLNS
Sequence: MSAIVDIIGREVLDSRGNPTVECDVLLESGVMGRAAVPSGASTGSREAIELRDGDKSRYLGKGVLKAVQNINIEIAESILGLDASEQAFLDRTLIDLDGTHNKARLGANATLAVSMAVARAAAEEAGLPLYRYFGGSGGMQLPVPMMNIVNGGAHANNSLDIQEFMVMPVGAENFRDALRCGAEIFHELKKILGAQGMPTTVGDEGGFAPNFKSNHGCLQTIMKAIEGAGYQAGEDVLLALDCAASEFYKDGKYHLAGEGLQLSSSEFSDYLGNLADQFPIVSIEDGMHESDWDGWADITKKLGKKIQLVGDDLFVTNTRILKEGIEKGIANSILIKINQIGTLTETFAAIEMAKRANYTAVISHRSGETEDSTIADIAVGTNAGQIKTGSLSRSDRIAKYNQLLRIEEDLGDVATYPGKSDFYNLKR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: YBEY_CLOBA
Sequence: MIYVDNRQEKMEVSDEFTNHLEKVIEFALKEEDVNIPSEISLLFVDNEEIREINNETRNIDRATDVLSFPMLDYPEKKVFKEVYTENDFSEADFDGDDLVLGDIVLSLERALEQSKEYNHSYEREASYLVVHSVLHLLGYDHMEEDDKVKMRKREEEILTALDIRR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPEB3_XENTR
Sequence: MQDDLLMDKSKAQQRQQPQQPPSSQTQQQQKEAASVAEPPSSRESSPPTHKDKMQMESPLLPGLSFQQEPPTTPSLSPSFGSTWSTGGSNSAVDDSFFPGITPVNGTMLFQNFPHHHHVNPVFGGTFSPQMGLAHQTQQQQRRSPASPNNHTAYTQRNAYSHQPILTNKPSSSPNSSSPSPSNWNNQQNAAWNTPSNPWGAMQPGRDPRRAVGVGVGVGVGVPSPLNPISPLKKTFSSNVIAPPKFSRASPLTPKSWVEDNAFRTDNGNTLLPLQDRNRPYDSFNLHTLENSLMDMIRTDHEPLKARMGLNFHHPGTDNIMALNTRSYGRRRGRSSLFPFEDGFLGDGHGDQSLSSGLSSPTHCQNGERIERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFHWS
What is the function of this protein?
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity).  Does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity).  Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity).  Inhibits differentiation of intermediate mesoderm from an early stage to inhibit pronephric differentiation but induce neural differentiation (PubMed:18472403).
What are the official names of this protein?
Cytoplasmic polyadenylation element-binding protein 3, CPE-BP3, CPE-binding protein 3, CPEB-3.
What is the protein family that this protein belongs to?
Belongs to the RRM CPEB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Synapse. Cell projection, dendrite. Postsynaptic density. Note=Predominantly cytoplasmic in unstimulated neurons but translocates to the nucleus following neuronal stimulation.
Protein: DBP9_DEBHA
Sequence: MGQDKKNLTAAAAAAYVDDSTTWESFGLDARLLQAIDQLGFENPTLIQSSAIPLAIEEKRDIIAKASTGSGKTAAYSIPIIQNLLQDESTEREIKSIILVPTRELSNQVSQFLEKLLIFCNSKIRLINISSNLSDQVINSLLINKPEIIVSTPAKLIQILEKNVNSNLINLSTVKNLTIDEVDLVLSYGYLEDLQKLESYLPIKKNLQTFLMSATINDDLNDIKSKFCSRPAILKLNDEDSNQNNLVQYYAKTTEFDKFLLTYVIFKLNLIKGKTLVFVNNIDRGYRLKLFLEQFGVRCCILNSELPINSRLNIVEQYNKNVYNLLIATDETNDFTIQEDEKDEGEEIEENKNEENDGKTSKNTKKPNQKKDKEYGVSRGVDFRNVACVLNFDLPTSSKSYIHRVGRTARAGKSGMALSFVLPLNEFGKHKTASLSTAKKDEKVLRRIVRQQSNNGFEIKPYQFDMKQVEGFRYRAEDAFRAVTQSAVREARIKELKNELVNSDKLKRFFEENPQDLASLRHDKELHPTRVQTHLKRVPEYLLPESARADHKKIGFVPFHKNKVHKNRKRKPSGRKPDPLKSFRPK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP9.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SPG5_YEAST
Sequence: MAVGGNNWSMWLRMSRVHLRQITKSLDRTLISLSHGNFSHQYNRNIFVTWWKSLFEASTAFRRASGLTVSPLTRRGIARFDHFRPVPNVSKFASFPRVPKGAPRGLFTNWNMTTSKRLLGQRAYSTSSIKFTQEAVNNMTISLRCFFNSLGGLNQCSHSNSCKAYQNASNVTSKQDHVQPVALKKLSQKDINFIRNLELFKIMKTQNEVVDETSAYYMEKPGSYIEFTISEFNVNGTFSAPLSFLDPSLLADLDEMIRNYKYELKSIYSSVDMILQNYGSLPITFHRNKIRIHFPNSTVVETEKLIAGLNIATGVIYADTSPDISLEGTNLNALVNVDNSGSVWSFVKEPSFPSRSAFSPILSDASYDTYELV
What is the function of this protein?
Required for survival at high temperature during stationary phase.
What are the official names of this protein?
Stationary phase protein 5.