PharMolix/UniProtQA huggingface dataset:
Protein: HMOA_BACSU
Sequence: MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNVRRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVKQGTYNQ
What is the function of this protein?
Allows bacterial pathogens to use the host heme as an iron source.  Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
What are the official names of this protein?
Heme-degrading monooxygenase HmoA, Heme oxygenase.
What is the protein family that this protein belongs to?
Belongs to the antibiotic biosynthesis monooxygenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSH3_MOUSE
Sequence: MALVTVSRSPPASGHSTPVGPTQDRVVRRRGRLQRRQSFAVLRGAVLGLQDGGDSNVASEADSEPMEEPSGEEQPTEDQTDKGQGLQSPWKQVQKRHLHLMVELLRPQDDIRLAAQLEAARPPRLRYLLVVSTGEELSEEAILLGVDFPDSSSHSCTLGLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPVSIQTMWATLQVLHQACEVALGSGLVPGGSALAWATYYQEKLNSDQGCLNEWMAMSDLESFRPPNAEPGQASEQEKMEQAILAELWQVLDTSDLDSVTSKEIRQALELRLGCPLQQYRDFIDNQMLLLMAQQDRASRIFPHLYLGSEWNAANLEELQKNRVSHILNMAREIDNFFPERFTYYNVRVWDEESAQLLPHWKETHRFIEDARAQGTRVLVHCKMGVSRSAATVLAYAMKQYGWDLEQALIHVQELRPIVRPNHGFLRQLRTYQGILTASRQSHVWEQKVGVVSPEEPLAPEVSTPLPPLPPEPGGSGEVMVMGLEGSQETPKEELGLRPRINLRGVMRSISLLEPSESESTPEAGGLPEVFSSDEEPLHPFSQLSRAKGGQRVRKGPWPALKSRQSVVALHSAALVASRTRAFQEQGQGQEQSEPGMSSTPRLRKVMRQASVDDSREEDKA
What is the function of this protein?
Protein phosphatase which may play a role in the regulation of actin filament dynamics.  Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.
What are the official names of this protein?
Protein phosphatase Slingshot homolog 3, SSH-like protein 3, SSH-3L, mSSH-3L.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus.
Protein: PLPP5_MOUSE
Sequence: MGTAALGAELGVRVLLFVAFLVTELLPPFQRRIQPEELWLYRNPYVEAEYFPTGRMFVIAFLTPLSLIFLAKFLRKADATDSKQACLAASLALALNGVFTNIIKLIVGRPRPDFFYRCFPDGLAHSDLTCTGDEDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRLCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDVECHKPFQDKHKLPSSQKPSELHHLEI
What is the function of this protein?
Magnesium-independent phospholipid phosphatase with broad substrate specificity.  Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate.  Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules.
What are the official names of this protein?
Phospholipid phosphatase 5.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: URE2_ALKEH
Sequence: MIPGEILPEDGEITLNAGRDTLTVEVTNTGDRPAQVGSHYHFYEVNDHLHFDREPTRGFRLDIAAGTAVRFEPGQSRTVQLVRYAGSGDIYGFQGRVMGPATGESA
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VDR_COTJA
Sequence: MVSISASGGYAMPCCCESQELQSSDMETPAVGTPEFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAMFTCPFSGDCKITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKESLKPKLSEEQQKVINILLEAHHKTFDTTYSDFNKFRPPVRSKFSSSTATHSSSVVSQDFSSEDSNDVFGSDAFGAFPEPMEPQMFSNLDLSEESDESPSMNIELPHLPMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFTMEDMSWTCGSNDFKYKVSDVTQAGHSMDLLEPLVKFQVGLKKLNLHEEEHVLLMAICILSPDRPGVQDTSLVESIQDRLSDTLQTYIRCRHPPPGSRLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPEHSMQLTPLVLEVFGNEIS
What is the function of this protein?
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells.  Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR.  The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity).  Plays a central role in calcium homeostasis (By similarity).  Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity).
What are the official names of this protein?
Vitamin D3 receptor, VDR, 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand- independent pathways; ligand-independent nuclear translocation is mediated by IPO4.
Protein: YD114_YEAST
Sequence: MVRKNKINRASGTTKHLKDFPSVILSLPSYNPSILSKNATALITGGSSGLGFELAKELSRRINKVIVADIQSFPTFAQVEYNNIFYYQCDITSLDEIKNLKKAIERDHGNINIIINNAGVAHIKKLEHMTNKEVEQLIDINLIGAYRIISTFAEDMIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTECNKTGIKTLLVCPGKIKTNMFIDVPTPSKLLAPDIIPSQLALAIISAMEHNHLQTLNAPYYVNLVPFFKTLSWPYRHLLKHFSGMDHVTSTSPRAINPKRSA
What are the official names of this protein?
Uncharacterized oxidoreductase YDL114W.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RRG9_ASHGO
Sequence: MLGSYFANLPHLYVHAAGLRALSTSAQLRTKAPSARKLIKMVTESSLSKKELESGTPIETQVGKGHEEVPEWKKQKLALHKKLNGEHWNPKKKLSRDQQDAVRMLKQRYPDMTNSNLADYFKVSAESIRRILKAKWQPNEDEMLEMQERWKRRGTRIKEELRESGAIPERRIRIASDGNAFRVRSVETPGEKSSKGISTPLQKNLHRLLRNTRK
What is the function of this protein?
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
What are the official names of this protein?
Required for respiratory growth protein 9, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RNT_CHRSD
Sequence: MSDGQARDLMAQRFRGFLPVVVDLETGGFNAQRDALLEIAAVTLTMDAQGNLMPDDTHAFHVRPFEGANIEQAALDFTGIDLDSPLRQQVALSEHDALGEIFKPVRKAIKANQCTRAILVGHNAAFDQGFLNAAVERNGIKRNPFHPFSCFDTATLGGLVYGQTVLARACRAAGIEFDNASAHSARYDTERTAELFCAMVNRYKNLGGWDLALKEQGMDED
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: RSPH1_HUMAN
Sequence: MSDLGSEELEEEGENDIGEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHRYQGKFLNKNPVGPGKYVFDVGCEQHGEYRLTDMERGEEEEEEELVTVVPKWKATQITELALWTPTLPKKPTSTDGPGQDAPGAESAGEPGEEAQALLEGFEGEMDMRPGDEDADVLREESREYDQEEFRYDMDEGNINSEEEETRQSDLQD
What is the function of this protein?
Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.
What are the official names of this protein?
Radial spoke head 1 homolog, Cancer/testis antigen 79, CT79, Male meiotic metaphase chromosome-associated acidic protein, Meichroacidin, Testis-specific gene A2 protein.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium. Note=Cytoplasmic in late spermatocytes, secondary spermatocytes and round spermatids. Gathered around metaphase chromosomes during meiotic divisions (By similarity).
Protein: MSD5_AMABI
Sequence: MSDINTARLPYVVFMSFIPPCVNDDIQVVLTRGE
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:18025465).
What are the official names of this protein?
MSDIN-like toxin proprotein 5.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: ARCA_STAAM
Sequence: MTDGPIKVNSEIGALKTVLLKRPGKELENLVPDYLDGLLFDDIPYLEVAQKEHDHFAQVLREEGVEVLYLEKLAAESIENPQVRSEFIDDVLAESKKTILGHEEEIKTLFATLSNQELVDKIMSGVRKEEINPKCTHLVEYMDDKYPFYLDPMPNLYFTRDPQASIGHGITINRMFWRARRRESIFIQYIVKHHPRFKDANIPIWLDRDCPFNIEGGDELVLSKDVLAIGVSERTSAQAIEKLARRIFENPQATFKKVVAIEIPTSRTFMHLDTVFTMIDYDKFTMHSAILKAEGNMNIFIIEYDDVNKDIAIKQSSHLKDTLEDVLGIDDIQFIPTGNGDVIDGAREQWNDGSNTLCIRPGVVVTYDRNYVSNDLLRQKGIKVIEISGSELVRGRGGPRCMSQPLFREDI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_BURM1
Sequence: MDHIRNFSIIAHIDHGKSTLADRIIQVCGGLADREMEAQVLDSMDIERERGITIKAQTAALSYRARDGKVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGVEVVPVLNKIDLPAANPENAIAEIEDVIGIDASDATRCSAKTGLGVEDVLEALIAKVPPPKGDPAAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKDKIKLMATGAQYPVEHIGVFTPKSRNLESLSAGQVGFIIAGIKELTAAKVGDTVTHATKAAAEPLPGFKEVKPQVFAGLYPVEANQYDALRESLEKLKLNDASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDLITTAPTVVYEVVQSDGSTIMVENPAKMPEPARIAEIREPIVTVNLYMPQDYVGSVITLCEQKRGSQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRSSDVVKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIIARENIKALRKNVLAKCYGGDITRKKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EX7L_STAA2
Sequence: MSDYLSVSALTKYIKYKFDQDPHLQSVLIKGELSNFKKHSSGHLYFNVKDKESVISAMMFKGSASKLNFEPKEGDEVLLEARVSVFERRGNYQIYVNKMQLDGIGNLYQKLEALKKKLTEEGCFDKANKKSIPKFPKKIAVLTASTGAAIRDIHSTINSRFPLAEQIQISTLVQGEKAKDDIIEKIEYADSLGVDTIIVGRGGGSIEDLWNFNEEAVVRAIYNCKTPIISAVGHETDFTLSDFAADIRAATPTQAAVIATPDQYELLQQIQQYQFTLTRFIKKHLEQQRKHVEHLSSYYKFKKPTLLYDQQIQRRDDLEKRLKQQIQATFEQQRHRLMLLQQRYNLKALLSSVNQEQQNNLQLTNQLVKLLNSKILSYKNDLKNKVENLNNLSPTNTMLRGYAIVNKKDEVITSTKDLTENDQLTLTMKDGLVDAKVTKVRCNND
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_LACLM
Sequence: MGNSFRSDRVAVEIQREINDILRNKVRDPRVQDVNITDVQLTGDLSQATVYYSLLSNLASDNEKAATALKKATGLFKSELAKRMTIFKIPDLTFAKDESVEYGSKIDELLRGLNDKSEY
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SGO1_MOUSE
Sequence: MAKERCQKRSFQDTLEDIKNRMKEKRNKNLAGIGKRKSFIVAPGQVPTNTATLLRYYQDNNRLLVLALENEKSKVREAQDVILQLRKECYYLTCQLYALKEKLTSRQSEETTQNWKGRPSDVVSSIDNTTRDLSGKSLQQIAVEETDCPYQTTEPSPAVTPETQGCDFDSGKVESTDEVLPRTISIRRHLRKDFSNISHSTTLEDCKASPRVAQSLEVKGSRCREVTVTLHRLENVCLWNKDQISLCSRLINPAKITETEVILSSKPEQIESKHKRARKRRAEQRRTKQRCKSKSSLRSKGNKNKDKQGLPPTTLDGGIGSCDAYDFNLKGTVHPTPFRQKMNNGCNKETDSSNSEVSDLECSTSEDESDDLYLPPSKRLRDYRESERAVTRPRSKRGLQYPDGKERKEVLPSTAPTGIPPETQESPRCSLKDVTNILQCPRVKIRKPSLPPKRREDSPAVALTKRRCSTIKSYKEPTLASKLRRGDPFTDLCFLNSPIFKQKRGMRCPKRRTKQTQ
What is the function of this protein?
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.  May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase.  Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A.  Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore.  Necessary for kinetochore localization of PLK1 and CENPF.  May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity.  Involved in centromeric enrichment of AUKRB in prometaphase.
What are the official names of this protein?
Shugoshin 1, Shugoshin-like 1.
What is the protein family that this protein belongs to?
Belongs to the shugoshin family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Colocalizes with NEK2 at the kinetochore. Colocalizes with and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform 3 does not localize to kinetochores during any stages of the cell cycle.
Protein: NUDT9_MOUSE
Sequence: MAGRSLGQAVATVSLSVALASVTVRSSACRAVPAPRNTFPTCGFHLNANIMSGSNGAKENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYNPVEYTAVSVLAGPQWADPQISESNFSPKFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKRDESGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQKSSAEKREIEEKLHALFSQEHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGETMDNLTLEAGDDAGKVKWVDISDQLKLYASHSQFIKLVAEKRDAHWSEDHAADSRGL
What is the function of this protein?
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
What are the official names of this protein?
ADP-ribose pyrophosphatase, mitochondrial, ADP-ribose diphosphatase, ADP-ribose phosphohydrolase, Adenosine diphosphoribose pyrophosphatase, ADPR-PPase, Nucleoside diphosphate-linked moiety X motif 9, Nudix motif 9.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudF subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ARLY_PHOV8
Sequence: MAQKLWEKNVRVNEEIDRFTVGRDREMDLYLAKHDVLGSMAHITMLESIGLLTAGELEMLLAELKNIYASAEKGEFVIEDGIEDVHSQVELMLTRKLGDVGKKIHSGRSRNDQVLVDLKLFTRAELKEVAEEVEQLFHVLISQSNTYKDVLMPGYTHLQIAMPSSFGLWFGAYAESLVDDMMFLQAAFKMCNRNPLGSAAGYGSSFPLDREMTTRLLGFDSMDYNVVYAQMGRGKMERNVAFALASIAGTVSKMAFDACMFSSQNFGFVKLPDECTTGSSIMPHKKNPDVFELTRAKCNKLQALPQQIMMIMNNLPSGYFRDLQIIKEVFLPAFRELKECLQMAAYIMDKIKINEHILDDNRYLYIFSVEEVNRLASEGMPFRDAYKKVGLDIEAGKFTHDKKVHHTHEGSIGNLCNDRIESLMRQVVDGFNFSVMEQAERSLLGR
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RB33B_MOUSE
Sequence: MTSEMESSLEVSFSSSCAVSGASGCLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVDIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPAWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQLPDNRISLKPETKPAVTCWC
What is the function of this protein?
Protein transport.  Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity).  It is involved in autophagy, acting as a modulator of autophagosome formation.
What are the official names of this protein?
Ras-related protein Rab-33B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Golgi apparatus, cis-Golgi network. Note=Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm (PubMed:18448665).
Protein: KYNU_KORVE
Sequence: MAAAAFDTTENFAIEMDARDPMSRFRGRFHIPPAPDGSASVYLVGHSLGLQPKTVRAYLEQELKDWETLGVEGHFRGKHPWMPYHRLLTEQTARLVCAQPSEVVVMNSLTVNLHLMMVSFYRPTRERHNILIEGSAFPSDQYAVQSQIKFHGFDPASSLLELCPRVGEATMRDEDILELIEREGQSIALILLGGVNYATGQAFDMAEITKAGHAQGCVVAFDCAHAAGNLELKLHEWDVDWAAWCSYKYLNGGPGCIGGCFVHERYARDFELPRFAGWWGHDQETRFKMGPEFHPMAGAEGWQLSNPSILTMAALRASMEIFDEAGIGKLRQRSIALTGYLEFLLDQQKSARFEIITPREPERRGAQLSIRVAAGNRSVCDRLVEEGALCDWREPDILRVAPVPLYCSYRDCYRFVQRFVANLN
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
Protein: ILVD_HALHL
Sequence: MADNRRSRVITQGVARTPNRAMLRAVGFRDEDFEKPIIGVGNAHSTITPCNVGIGAMARRAEEALREVGAMPMKFGTITVSDGITMGTEGMKYSLVSREVIADSIETVGGGQRMDGMLATGGCDKNMPGAMMALARLDIPGIFVYGGTIKPGHYKGEDLTVVSAFEAVGQYNAGNLSEADLKGVEENACPGAGACGGMFTANTMSSAFEAMGMSLMGSSTVSAEDDEARDVAAEASRVLMDAVHHDRRPSSILTREAFENAFAVVMALGGSTNAVLHLLAIANTAEVPFDLDDVERIRRKVPVLCDLKPSGRFVTSQFHEVGGTPQVMRILLEQGLLHGHCQTITGQTIEALIGHLPPEPPADQEIIMPFDRPLYPEGHLAILRGNLAEEGAVAKVSGIQQRRISGPARVFDSEEECLEAILADGVQAGDVVIVRYEGPKGGPGMREMLAPTSAIIGKGLGDAVGLITDGRFSGGTYGMVVGHVAPEAYDGGTIALIAEGDTVTIDADQNLLQVEVDDAELERRRSQWQVPRPRYRRGVLGKYARLAASASRGAVTDADLFPEQE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CYB_ARCGZ
Sequence: MTNIRKMHPLAKIINNSLIDLPAPSNISAWWNFGSLLAVCLALQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWVIRYMHANGASMFFICLYMHVGRGLYYGSYTLTETWNIGIILLFTIMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFVVSALVMVHLLFLHETGSNNPSGVSSDSDKIPFHPYYTIKDILGALLLILILMLLVMFSPDLLGDPDNYIPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILILAIIPLLHTSKQRGMMFRPISQFLFWLLVADLLALTWIGGQPVEYPFITIGQLASILYFAILLILMPIAGIIENNILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TSR3_METMA
Sequence: MNQTKSRDIPLYIYHAGQCDPKKCTGRKMARFELARLYDRISRLPRSAILLDPMAEKALSPADDPKKGIIVLDCSWEEVERVFPELEKLNLEHRALPYMLAGNPVNFGRPFKLNSAEAFAAALYILGYKEQAEKVMSKFNWGHSFLELNREPLEEYSTAKNSTEIVEIQSHYI
What is the function of this protein?
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M. jannaschii 16S rRNA.  It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
What are the official names of this protein?
16S rRNA aminocarboxypropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. TSR3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGH2_SHV21
Sequence: MADSPNRLNRAKIDSTTMKDPRVLNNLKLRELLLPKFTSLWEIQTEVTVDNRTILLTWMHLLCESFELDKSVFPLSVSILDRYLCKKQGTKKTLQKIGAACVLIGSKIRTVKPMTVSKLTYLSCDCFTNLELINQEKDILEALKWDTEAVLATDFLIPLCNALKIPEDLWPQLYEAASTTICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKDQVSEAFSLYDLEIL
What is the function of this protein?
May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.
What are the official names of this protein?
Cyclin homolog, V-cyclin.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin D subfamily.
Protein: CC103_DANRE
Sequence: MENSDVINFSCLEKELHSALQADRKYQRENDAKFRALNQKVASYEEFRDIVLASHLKPLDRNDISGSPRKQPWNPVACRTNYVCASSEQVQPQLSEVQPRSASEFIRDWRRFAGCSFEKYSLLVSLGGEALQKIFSTEIGLGLLGEFLLILSQCLKSGDEDRVTGVLDGLSKTGRFSINLSLLSQAEQEACEELFNKLKVAAGECHPYKDNSNTSVVCEAGLTHMEDNKTDITTTLKELAGKYGTEK
What is the function of this protein?
Dynein-attachment factor required for cilia motility.
What are the official names of this protein?
Coiled-coil domain-containing protein 103, Protein schmalhans.
What is the protein family that this protein belongs to?
Belongs to the CCDC103/PR46b family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium, flagellum.
Protein: ZN501_PONAB
Sequence: MNSSQISLKMKHGRVNMQKKPSKCSECGRFFTQRSSLTQHQRIHRGEKPYVCSECGSCFRKQSNLTQHLRIHTGEKPYKCNECEKAFQTKAILVQHLRIHTGEKPYKCNECGKAFCQSPSLIKHQRIHTGEKPYKCAECGKAFSQSVCLTRHQRSHSGDKPFKCNECGKAFNQSACLMQHQRIHSGEKPYTCTECGKAFTQNSSLVEHERTHTGEKLYKCSECEKTFRKQAHLSEHYRIHTGEKPYECFGCGKSFRHSSALLRHQRLHAGE
What is the function of this protein?
May be involved in transcriptional regulation (By similarity).  Essential for Golgi structural integrity (By similarity).
What are the official names of this protein?
Zinc finger protein 501.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.