PharMolix/UniProtQA huggingface dataset:
Protein: CHRD_XENLA
Sequence: MQCPPILLVWTLWIMAVDCSRPKVFLPIQPEQEPLQSKTPAGCTFGGKFYSLEDSWHPDLGEPFGVMHCVLCYCEPQRSRRGKPSGKVSCKNIKHDCPSPSCANPILLPLHCCKTCPKAPPPPIKKSDFVFDGFEYFQEKDDDLYNDRSYLSSDDVAVEESRSEYVALLTAPSHVWPPVTSGVAKARFNLQRSNLLFSITYKWIDRLSRIRFSDLDGSVLFEHPVHRMGSPRDDTICGIWRSLNRSTLRLLRMGHILVSLVTTTLSEPEISGKIVKHKALFSESFSALLTPEDSDETGGGGLAMLTLSDVDDNLHFILMLRGLSGEEGDQIPILVQISHQNHVIRELYANISAQEQDFAEVLPDLSSREMLWLAQGQLEISVQTEGRRPQSMSGIITVRKSCDTLQSVLSGGDALNPTKTGAVGSASITLHENGTLEYQIQIAGTMSTVTAVTLETKPRRKTKRNILHDMSKDYHDGRVWGYWIDANARDLHMLLQSELFLNVATKDFQEGELRGQITPLLYSGLWARYEKLPVPLAGQFVSPPIRTGSAGHAWVSLDEHCHLHYQIVVTGLGKAEDAALNAHLHGFAELGEVGESSPGHKRLLKGFYGSEAQGSVKDLDLELLGHLSRGTAFIQVSTKLNPRGEIRGQIHIPNSCESGGVSLTPEEPEYEYEIYEEGRQRDPDDLRKDPRACSFEGQLRAHGSRWAPDYDRKCSVCSCQKRTVICDPIVCPPLNCSQPVHLPDQCCPVCEEKKEMREVKKPERARTSEGCFFDGDRSWKAAGTRWHPFVPPFGLIKCAICTCKGSTGEVHCEKVTCPKLSCTNPIRANPSDCCKQCPVEERSPMELADSMQSDGAGSCRFGRHWYPNHERWHPTVPPFGEMKCVTCTCAEGITQCRRQECTGTTCGTGSKRDRCCTKCKDANQDEDEKVKSDETRTPWSF
What is the function of this protein?
Potent dorsalizing factor.  Has potent axis-forming activities including the ability to recruit neighboring cells into secondary axes.  Regulates cell-cell interactions in the organizing centers of head, trunk and tail development.
What are the official names of this protein?
Chordin, Organizer-specific secreted-dorsalizing factor.
What is the protein family that this protein belongs to?
Belongs to the chordin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNC_CHLTE
Sequence: MSLQFLRSEASDGAGETSDASSADFLLDPQTATHLARLTGRPCNRLIYRTALTHRSVLHDHHSEEHKPESNQRLEFLGDAVLDLLISEHLFKQFPGSDEGHLSSNRAKIVNRKSLAAFALELQLGEHLIIGESADKQKIRTSESALADALEALVGAIYLDQGLAGAERFITNHVIAKVDLHKLVEAEYNYKSRLIEYTQSRQLPPPLYTVITEEGAEHEKTFVVEVSCNGQPLGRGTAPRKKDAEQLAAKEAMKRLESGDLGNLNEPSPQNS
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KV112_HUMAN
Sequence: MDMRVPAQLLGLLLLWFPGSRCDIQMTQSPSSVSASVGDRVTITCRASQGISSWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 1-12.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: ATG18_YEAS7
Sequence: MSDSSPTINFINFNQTGTCISLGTSKGFKIFNCEPFGKFYSEDSGGYAIVEMLFSTSLLALVGIGDQPALSPRRLRIINTKKHSIICEVTFPTSILSVKMNKSRLVVLLQEQIYIYDINTMRLLHTIETNPNPRGLMAMSPSVANSYLVYPSPPKVINSEIKAHATTNNITLSVGGNTETSFKRDQQDAGHSDISDLDQYSSFTKRDDADPTSSNGGNSSIIKNGDVIVFNLETLQPTMVIEAHKGEIAAMAISFDGTLMATASDKGTIIRVFDIETGDKIYQFRRGTYATRIYSISFSEDSQYLAVTGSSKTVHIFKLGHSMSNNKLDSDDSNMEEAAADDSSLDTTSIDALSDEENPTRLAREPYVDASRKTMGRMIRYSSQKLSRRAARTLGQIFPIKVTSLLESSRHFASLKLPVETNSHVMTISSIGSPIDIDTSEYPELFETGNSASTESYHEPVMKMVPIRVVSSDGYLYNFVMDPERGGDCLILSQYSILMD
What is the function of this protein?
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  May negatively regulate FAB1 activity by sequestering or masking VAC7 from FAB1.  Necessary for proper vacuole morphology.  Plays an important role in osmotically-induced vacuole fragmentation.  Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy.  Involved in correct ATG9 trafficking to the pre-autophagosomal structure.  Might also be involved in premeiotic DNA replication.  With ATG2, protects ATG8 from ARG4-mediated cleavage (By similarity).
What are the official names of this protein?
Autophagy-related protein 18, Cytoplasm to vacuole targeting protein 18, Needed for premeiotic replication protein 1, Swollen vacuole phenotype protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Requires VAC7 for vacuole membrane localization. Under mid-log phase growth, localizes to the vacuolar membrane; but when cells are starved, is almost completely released from the vacuole membrane (By similarity).
Protein: HXK1_ORYSJ
Sequence: MAAAAVAADQKVVTMTSLREGCACAAPPAAAAPPMPKMAAAQRVVAELREACATPAARLAEVAAAMAGEMEAGLAVEGGSSEMKMIVSYVDSLPTGGEEGSYYALDLGGTNFRVLRVRLAGGGVAERVAREVPIPPGLMSGGGATSECLFGFIASALAEFVGEEEEEGGLDGGERELGFTFSFPVHQTSIASGTLIRWTKAFAVDDAIGEDVVAALQAAMSERGLDMRVSALINDTVGTLAAGSYYDEDVVAAVILGTGTNAAYVEDATAIAKLHPSQLPASNTMVINTEWGSFASPCLPLTEFDEALDQESLNPGEQTYEKLISGMYLGEIVRRVLLKISSRCPSLLGGAGELATPFVLRTPDVSAMHHDETPDLSIVGEKLERTLGIRGTSPEARRMVVEVCDIVATRAARLAAAGIVGILKKIGRVDGGEGRRRRSVVAVDGGLFEHYGKFRRCMESAVRELLGEAAAERVVVKLASDGSGLGAALVAAAHSQRA
What is the function of this protein?
Fructose and glucose phosphorylating enzyme (PubMed:16552590).  Acts as positive regulator of leaf senescence by mediating glucose accumulation and inducing an increase in reactive oxygen species (ROS) (PubMed:34879830).
What are the official names of this protein?
Hexokinase-1.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
Protein: RL29_VIBCM
Sequence: MKAQDLREKSVEELNSELLNLLKEQFNLRMQAATGQLQQTHTLKAVRRDIARVKTVLTEKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: Y1853_VIBCH
Sequence: MKLNPLILGLLLSFSAGHSLADVVLKVPENIDLLSVNMQKPKSEGGLFGDKTIMLKDGTNQIVFRYIPTFDDGDDVKKVYSDTIIAKFESENATLHFKIPSYRNIKEANEKIQTMEWQLVDEKGQSVALVEDKLLNPGVQWGRNYSQEATEYNQNGGVAAIGYLKVVTNEAQLSENTTQVIMSEASQPLEVVGSSNNLTQLQLWYSKASKEERKAFKKWMVDQE
What are the official names of this protein?
UPF0319 protein VC_1853.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: TRMB_ARATH
Sequence: MDNETKATTFSKSTGLPRKRFYRARAHSNPLSDSHFPIPISPAHVDYSLHFPKFVEADNKFIKKVEFADIGCGFGGLLISLATLFPDTLMIGMELRDKVTEYVKERILALRRTSSEGQYENISVVRTNSMKYIPNYFEKGQLSKMFFLFPDPHFKEKNHRRRVISTHLLDEYAYVLRAGGIIYTITDVEELGEWMKSCLEKHPMFESLTQEELVSDPVVELLCSATEEGQKVARNGGQTFRAVFRRIAYVS
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TSAD_BACFR
Sequence: MSTIILGIESSCDDTSAAVIKDGYLLSNVVSSQAVHEAYGGVVPELASRAHQQNIVPVVHEALKRAGVTKEELSAVAFTRGPGLMGSLLVGVSFAKGFARSLNIPMIDVNHLTGHVLAHFIKEEGEANEQPDFPFLCLLVSGGNSQIILVKAYNDMEILGQTIDDAAGEAIDKCSKVMGLGYPGGPIIDRLARQGNPKAYTFSKPHISGLDYSFSGLKTSFLYSLRDWMKEDPDFIEHHKNDLAASLEATVVDILMDKLRKAAKQYKINEVAVAGGVSANNGLRNAFREHAEKYGWKIFIPKFSYTTDNAAMIAITGYFKYQDKDFCSIEQPAYSRVTL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S22AC_RAT
Sequence: MAFPELLDRVGGRGRFQLLQAVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIPGDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDADTEPCEDGWVYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLLMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGRLDQSLRELQRVAAVNRRKAEADTLTVEVLRSAMQEEPNGNQAGARLGTLLHTPGLRLRTFISMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQASSLVLPGLCILANILVPREMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVGLGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKKVTHDIAGGSVLKSARL
What is the function of this protein?
Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:21074513).  Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:21074513).  Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:21074513).  Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (By similarity).  Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption.  Orotate transport is Cl(-)-dependent (By similarity).
What are the official names of this protein?
Solute carrier family 22 member 12, Urate anion exchanger 1, URAT1, Urate:anion antiporter SLC22A12.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Protein: COAD_STRS7
Sequence: MSGKIGLYTGSFDPVTNGHMDMIKRASHLFEHVYVGIFNNPNKQGFFTFELRAQMLREAVCALPNVTVVSAEHGLAVDLARELSVTHLIRGLRNTADFDYEAGLEYFNHRLAPEIETIYLMATHDLQPISSSRIRELIAFRAPITGLVPQAVINQVEKMNENNKKI
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y035_HAEI8
Sequence: MTIENDYAKLKELMEFPAKMTFKVAGINREGLAQDLIQVVQKYIKGDYIPKEKRSSKGTYNSVSIDIIAENFDQVETLYKELAKVEGVKMVI
What are the official names of this protein?
UPF0250 protein NTHI0035.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: ECTC_NOCFA
Sequence: MIVRTTDEITGTERDVAGPGWRSKRIVLGGDGVGFSFHETTIDAGTTHEFHYVHHIEAVWLVEGEGTLTDLDNDQVYDLRPGTMYLLNGHEKHRVQARTTMRMMCVFNPPVTGQEVHDENGVYPLVAVPAS
What is the function of this protein?
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
What are the official names of this protein?
L-ectoine synthase, N-acetyldiaminobutyrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the ectoine synthase family.
Protein: ACKA_PORGI
Sequence: MKVLVLNCGSSSVKYKLLEMPKGDVLAQGGVEKLGLPGSFLKLTMPNGEKVVLEKDMPEHTIAVEFILSVLKDDKYGCIKSYEEIDAVGHRLVHGGEKFSNSVEITPEVIAKVEECIPLAPLHNPANLKGVVAIEKLLPGIRQVGVFDTAFFQTMPEHVYRYALPYDMCNKHGVRRYGFHGTSHRYVSARACEILGLDYDKTRIITAHIGNGASIAAIKNGKALDVSLGMTPVEGLMMGTRSGDVDPGVLTFLMEAEGLEAAGISELINKKSGVLGVSGVSSDMREIEDAIKNGNERATLAMTMYDYRIKKYVGAYAAAMGGVDVLVFTGGVGENQYTTREKVCTDMEFMGIVFDSKVNEGMRGKEMVISKPESKVTVIVVPTDEEYMIASDTMTILK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_STRCO
Sequence: MANAPVQRMSKLMAKTLRDDPADAEVLSHKLLVRAGYVRRTAAGLWSWLPLGKKVLGNIERIVREEMDAIGAQEVQLPALLPREPYEATGRWQEYGPELFRLQDRKGGDYLLGPTHEEIFTLLVKDQASSYKDLPVILYQIQNKYRDEARPRAGILRGREFLMKDSYSFDVADEGLAESYALHRAAYQRIFERLGLDYRIVAATAGAMGGSKSEEFLAPAEAGEDTFADCPNCDYAANTEAITFRLTPVDATDVPAAEDIPTPDTPTIETLAASLGVEASATLKNLLVKVDGEIVAVGVPGDREVDMDKVEAHFAPAAVELVTAEDFVGRPDLVRGYVGPQGLGEKVTYIADPRVAPGTAWITGANKADTHAKNVVAGRDFEVDTYVDVVVVREGDPCPNCGTGLKLDRAIEIGHIFQLGRKYADALKLDVLGQNGKPARVTMGSYGIGVSRAVAALAEQHADDKGLVWSKEVAPADVHVVAAGKALQTELALEVSDKLAAAGVRVLVDDRAGVSPGVKFTDAELIGVPQILVAGRRSGEGVVELKDRRTGEREEVTVEEALTRLTS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_STAA2
Sequence: MKIDYLTLFPEMFDGVLNHSIMKRAQENNKLQINTVNFRDYAINKHNQVDDYPYGGGQGMVLKPEPVFNAMEDLDVTEQTRVILMCPQGEPFSHQKAVELSKADHIVFICGHYEGYDERIRTHLVTDEISMGDYVLTGGELPAMTMTDAIVRLIPGVLGNEQSHQDDSFSDGLLEFPQYTRPREFKGLTVPDVLLSGNHANIDAWRHEQKLIRTYNKRPDLIEKYPLTNEDKQILERYKIGLKKG
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2125_NITEU
Sequence: MLLTIDDVLTQEELAIARSMLARSAWVSGLVTAGTQAAQVKNNQQVQENDPQIVNLRRLVLGALNRNALFFTATLPEKIVPPFFNRYSGETNHYGFHVDNAMRLLPDGSGYVRTDVSATLFLSDPQEYDGGELVINDTFGQHGVKLQAGSMVIYPSSSIHQVTPVTRGERLACFMFIQSMVRNPDQRRLLYEMDMALLQLRQNIGETPAVVSLTGTYHNLLRQWADS
What are the official names of this protein?
PKHD-type hydroxylase NE2125.
Protein: RECO_RHOPT
Sequence: MEWSDEGIILGVRRHGESAAIVELLTRGHGRHLGMVRGGASARMRPLLQPGNSVLASWRARLDEHLGYYQLEATKMRAATLLGSSHAVYGVTHLASLARLLPERDPHEEIYQRLVLTLDDFDDFGVAAAHLIRFELAILAELGFGLDLSACAATGSTTELIYVSPKSGSAVSRSAGEPWRDRLLRLPAFLRDDEAESGNGWSGQDLFDGFELTGRFLLRNVLEPRGQSHSDARAGFINAITRALQRPAES
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RABE1_MOUSE
Sequence: MAQPGPAPQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAIMKETVRDYEHQFHLRLEQERAQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRVNKRKDNKKTDTEEEVKIPVVCALTQEESSTPLSNEEEHLDSTHGSVHSLDADLMLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSSSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTVSLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKEKQELEDFLKQSAEDSSHQISALVLRAQASEVLLEELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQLAEDFILPDTVEVLRELVLKYRENIVHVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKVNLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
What is the function of this protein?
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A.  Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes.  Involved in KCNH1 channels trafficking to and from the cell membrane.  Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.  Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (PubMed:25405894).
What are the official names of this protein?
Rab GTPase-binding effector protein 1, Rabaptin-5, Rabaptin-5alpha.
What is the protein family that this protein belongs to?
Belongs to the rabaptin family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
Protein: GUAC_SALPK
Sequence: MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQTWSGVPIIAANMDTVGTFEMAQALAGFDILTAVHKHYTVEEWAAFINTASADVLKHVMVSTGTSDADFEKTVQILALNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTMPGDVAKAFGGGADFVMLGGMLAGHEESGGSVVEENGEKFMLFYGMSSESAMNRHVGGVAKYRAAEGKTVKLPLRGPVGNTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRIFNSL
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Protein: PG204_VAR67
Sequence: MMKMTMKMMVHIYFVSLLLLLFHSYAIDIENEITDFFNKMKDTLPAKDSKWLNPTCIFGGTMNNMAAIGEPFSAKCPPIEDSLLSRRYINKDNVVNWEKIGKTRRPLNRRVKNGDLWIANYTSNDSHRMYLCTVITKNGDCIQGIVRSHVRKPSSCIPEIYELGTHDKYGIDLYCGIIYAKHYNNITWYKDNKEINIDDIKYSQTGKELIIHNPALEDSGRYDCYVHYDDVRIKNDIVVSRCKILTVIPSQDHRFKLILDSKINVIIGEPANITCTAVSTSLLFDDVLIEWENPSGWLIGFDFDVYSVLTSRGGITEATLYFKNVTEEYIGNTYKCRGHNYYFEKTLTTTVVLE
What is the function of this protein?
Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1.  Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
What are the official names of this protein?
Soluble interferon alpha/beta receptor OPG204, S antigen.
What is the protein family that this protein belongs to?
Belongs to the interleukin-1 receptor family.
Protein: PRMA_ACIBS
Sequence: MKWLQIHITVDQEQVEFTETLLMSLGAVSVTLDDAEDQALLEPLPGETPLWNKVIVTGIYQQDEQDPIDVDTLEAFLKAQLPDVPMRHEELEDQVWERAWMDYYEPIQIGEKFWIVPEWLEPPEADATNIKLDPGLAFGTGNHASTFLCLQWLGKTDVKNKIVIDYGCGSGILGVAALLLGAKKVYATDIDPQAVLATKQNAELNGVLDRLYVGLPEEFDQEFKPQQADVLVANILAGPLMALAPEFAKLLKSDGDFALAGVIEEQVVDVSGVYSEFFDILDVEKREENWCRISGKRKTTN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCNA_SHIDS
Sequence: MTEFTTLLQQGSAWFFIPSAILLGALHGLEPGHSKTMMAAFIIAIKGTIKQAVMLGLAATISHTAVVWLIAFGGMVISKRFTAQSAEPWLQLISAVIIISTAFWMFWRTWRGERNWLENMHEHEHDHEHHHHDHEHHQDHDHDHDHEHHHHHEHGDNEEYQDAHARAHANDIKRHFDGREVTNWQILLFGLTGGLIPCPAAITVLLICIQLKALTLGATLVVSFSIGLALTLVTVGVGAAISVQQVAKRWSGFNTLAKRAPYFSSLLIGLVGVYMGVHGFMGIMR
What is the function of this protein?
Efflux system for nickel and cobalt.
What are the official names of this protein?
Nickel/cobalt efflux system RcnA.
What is the protein family that this protein belongs to?
Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEU1_MYCBO
Sequence: MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAHRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: TNFA_TRIVU
Sequence: MSTESMIRDLELAEEALKRKARGPLGLGRCLCLTLISSFLLAGATVLFCLLHFGVIGPQKEQESTDTFLDMKPLTQRVRSLQNESAKPVAHLIADQLAEGQLLWVGDVANTLLMNGMELVDNQLVLPSTGLYLVYSQLLYKGSQCGKESLVLTHKISRFTLSYQKKVTLLANIRSSCRKAAEDDGEPSAWYEPVYLAGVFQLTEGDKLVVDTNYPENLDFAEPGQLYFGAIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.