PharMolix/UniProtQA huggingface dataset:
Protein: DTD_DROME
Sequence: MRAVIQRVKAAKVTVLDELVSSIGPGLCVLVGIKASDTAKDVEYLVRKILALRLFEEEGKRWQKSVKDLNLELLCVSQFTLYHRLKGNKPDFLAAMKGEEAQELYNQFLDRLGQSYDSTKIKDGKFGAYMQVHIENDGPVTINLESPEQKDTDREVDK
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs (By similarity).  Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) (PubMed:27224426).  Deacylates mischarged endogenous and E. coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (PubMed:28362257).  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity).  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity).
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, Gly-tRNA(Ala) deacylase, Gly-tRNA(Gly) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1909_BRUA4
Sequence: MAKSRNEPGNIELPGFSDTLQLTPKIDKPHYAGHRDRLKQRFRDTPDALADYELLEMLLFRAIRRADTKPLAKALLMRFGSIAEVLAAPEKLIAEVPGAGPTVAHELKLVEAVAKRSARSTVMEREVLGSWNKVIEYCTAAMAYETREQFRILFLDKKNKLIADEVQQTGTVDHTPVYPREVVKRALELSATAIILVHNHPSGDPTPSRADIDMTKQLVNAAKALNITVHDHVIVGKHGHASFRGLGLI
What are the official names of this protein?
UPF0758 protein Oant_1909.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: VRAS_STAAS
Sequence: MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKTQIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVSQQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNKEDSYDD
What is the function of this protein?
Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae.  Modulates also quorum-sensing signal production acting on both negative and positive modulators.  Functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PprB.
What are the official names of this protein?
Sensor protein VraS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABA_YERPE
Sequence: MVDKRESYTKEDLEASGRGELFGAGGPPLPAGNMLMMDRIVKMIEDGGSHNKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPDAKKVTYRINFKRVIMRKLIMGVADGEVLVDGKVIYTATDLKVGLFKDTNAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y575_STAA3
Sequence: MKNTFLICDECQAVNIRTLQKKLEKLDPDAEIVIGCQSYCGPGRRKTFTFVNNRPLAALTEEELIEKVSQQLKKPRDPEEEERLRKRHEERKRRKVEQDRKLKEKLEKRKAQQ
What are the official names of this protein?
UPF0741 protein SAUSA300_0575.
What is the protein family that this protein belongs to?
Belongs to the UPF0741 family.
Protein: RIBC1_MOUSE
Sequence: MYKLDLVSDPRELAAIEARRNREKERQSRFFNVRNRVMGVDVEALNYQVEERKFREAIERNKDIAYGTKHAHYDLVAQMLEKEEAERAYRLSKRVQDFREQRQQQYKNGHEFDFWDPDQFQEFRVPYYEKDAYFGPASMQYFFGEDLERASHVRMQQEQMRYNLEKQLQEQQAAREEEARAALLSDQLRLAADTRAAELARLEESCRAAMRTAMANANKAQAAKQALQQRREQQRQQEANLTEVKKQVTSDLLTENPQVAQRANAPHRVLPYCWKGMSAEQRAAIRKTQETQRQEKKEQRQAEKLVEAEWGRQNKRLAEAALELEEQERELCAEFRRGLGSFNRELAKEQQAQQNYLNSVIYTNQPTAHYYLQFNTSSR
What are the official names of this protein?
RIB43A-like with coiled-coils protein 1.
What is the protein family that this protein belongs to?
Belongs to the RIB43A family.
Protein: RNZ_EXISA
Sequence: MKLQFLGTGSGMPSKQRNVSGLALDLSNVTWLIDCGEGTQHQMLYTKIKPRKVTAVWVTHLHGDHVFGLPGFLSTRSALDGTAPLTVYGPKGLKKWLEATLRVTGSHLGYELTVTEYSDGDTFIQDDHLVTVRKLEHRFPSFGFRIDGPEKPGMLRVDLVRELGVPSGPIYRTIKESDRFEFEGKWYDSKEYVTEPIPGKIVAILGDTIPCENARKLADGADLLVHEATFMEAEQALARKYGHSTTREATALANACAVGKLIVTHISARYVGREEEFVQEVVSDFPSSLVATDFLEYTVGD
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: GATA4_CHICK
Sequence: PVYVPTTRVPSMLPSLPYLPSSGSSQQASPVSSHSIWTQPGAESAAYNPGSSHPPVSPRFSFSTSTPIPSTSSRDAAAAYSSSLSLSANGREQYSRGFGSSYSSPYPAYVSPEMATTWTSSPFDSPMLHNLQSRGTPAAARHANIEFFDDYSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLFKPQRRLSASRRVGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKTKTPAGPSSSESLTPTTSSTSSSSSATTTEEMRPIKTEPGLSSHYGHPSPISQAFSVSAMSGHGSSIHPAISALKLSPQAYQSAISQSPQASSKQDSWNSLVLAENHGDIITA
What is the function of this protein?
Transcriptional activator.  Binds to the consensus sequence 5'-AGATAG-3' (By similarity).
What are the official names of this protein?
Transcription factor GATA-4, GATA-binding factor 4.
What are the subcellular locations of this protein?
Nucleus.
Protein: GMHB_THEAC
Sequence: METVRIIYVRDNQTLKTVFVDRDGTINRDCPYCHELDDLQIYDDTVGILKHYQGKGYRIIIVTNQSGIGRGYFSMEEFRRFNDGVVNRLLDLGVKVSATYFCPHRPDEGCSCRKPGIGLINEALSDFRVDIGGSLVIGDRDDVDGQLARNLGLPFRIVSH
What is the function of this protein?
Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.
What are the official names of this protein?
Probable D-glycero-D-manno-heptose-1,7-bisphosphate 7-phosphatase, D,D-heptose 1,7-bisphosphate phosphatase, HBP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the GmhB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1985_EMENI
Sequence: MIPPCDPTILEHNPLFKRLHQHLTASLLNPDGSTRTTDAQPARREIIMELRGCRMRNAKKQIKKQMLRQLALDPDNELPDECREPLAIISLYLEASPNELDQIRDPRDGVDVDTLLASDFEKFYAKLPFIMPHFTRSLASALHDLRSLANAGNKAALSNTSTEGSRSRMQVRCRSKAARQDPLGPQLSERLQNLRHLQLSELAGGRTRMAGTAAEVLAMRAAILERTVTLLERTKHGAMARATKAKAEHLAAVARGLEGKLRVMRLDALAAIHTPEVNAALSHYFQHLRNARERLEERRRLVLDELKAYEDADSSTINGPAKPGPIVGFIRQYGNLIKQIEDIKSEIRRLQR
What are the official names of this protein?
Uncharacterized protein AN1985.
Protein: MET30_YEAST
Sequence: MRRERQRMMSFEDKDKDDLDNSNSNNSSEMTDTAMMPPLKRLLITGSSDDLAQGSSGKKKMTMATRSPSSSPDLATNDSGTRVQPLPEYNFTKFCYRHNPDIQFSPTHTACYKQDLKRTQEINANIAKLPLQEQSDIHHIISKYSNSNDKIRKLILDGILSTSCFPQLSYISSLVTHMIKIDFISILPQELSLKILSYLDCQSLCNATRVCRKWQKLADDDRVWYHMCEQHIDRKCPNCGWGLPLLHMKRARIQQNSTGSSSNADIQTQTTRPWKVIYRERFKVESNWRKGHCRIQEFKGHMDGVLTLQFNYRLLFTGSYDSTIGIWDLFTGKLIRRLSGHSDGVKTLYFDDRKLITGSLDKTIRVWNYITGECISTYRGHSDSVLSVDSYQKVIVSGSADKTVKVWHVESRTCYTLRGHTEWVNCVKLHPKSFSCFSCSDDTTIRMWDIRTNSCLKVFRGHVGQVQKIIPLTIKDVENLATDNTSDGSSPQDDPTMTDGADESDTPSNEQETVLDENIPYPTHLLSCGLDNTIKLWDVKTGKCIRTQFGHVEGVWDIAADNFRIISGSHDGSIKVWDLQSGKCMHTFNGRRLQRETQHTQTQSLGDKVAPIACVCIGDSECFSGDEFGCVKMYKFDLND
What is the function of this protein?
Substrate-recognition component of the SCF(Met30) complex, an E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9716410, PubMed:10637232, PubMed:14660673).  Negatively regulates sulfur amino acids biosynthesis genes expression (PubMed:8524217, PubMed:15689486, PubMed:15870262).  Controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the SCF(Met30) complex (PubMed:8524217, PubMed:15689486, PubMed:15870262).  Required for the efficient binding of CDC45 and MCM proteins to origins of replication (PubMed:8524217, PubMed:15689486, PubMed:15870262).  Required for efficient expression of G1 cyclins (PubMed:15870262).  The SCF(Met30) complex catalyzes ubiquitination and degradation of the Cdk-inhibitory kinase SWE1 (PubMed:9716410).  Involved in the S-adenosylmethionine (AdoMet)-mediated inhibition of the transcription function of MET4 (PubMed:8524217, PubMed:10637232).  The SCF(Met30) complex mediates ubiquitination and subsequent degradation of MET4 and the cellular response to cadmium (PubMed:10637232).  The SCF(Met30) complex acts as an inhibitor of autophagy by promoting ubiquitination and degradation of ATG9 in normal conditions (PubMed:33443148).
What are the official names of this protein?
F-box protein MET30, E3 ubiquitin ligase complex SCF(Met30) subunit MET30, Methionine-requiring protein 30.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MET30/SCONB/SCON-2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS6_AEDAE
Sequence: MKLNVSFPATGAQKTFEVMDDHKLRHFYDKRMGAEITADHLGDEWKGYVFKIAGGNDKQGFPMKQGVLTNTRVRLLLKKGHSCYRPRRTGERKRKSVRGCIVDQNLSALALIVVKKGEKDIPGLTDTTVPRRLGPKRASNIRKLYNLTKEDDVRQFVVKRPLPEKDGKKARTKAPKIQRLITPVVLQRKRHRLAIKKRRVESRKEAEAEYMKILHLRRRQERIRRRSRLSSMRDSRSSVGEERDKEKEKAAAKAAKKVAKKEAKKEVKKVTEAAKKADAKAKTKAEPKKAEKKAETGKKTAGDKKEKKVEKKAAPAVAKKEAPKRKPEAAKGDASAAKKEKKQKKK
What is the function of this protein?
Component of the 40S small ribosomal subunit (By similarity).  Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
What are the official names of this protein?
40S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: ABRA_RAT
Sequence: MAPGETEREAGPAKSALQKVRRATLVINLARGWQQWANENSTRQAQEPAGWLPGATQDLPHTPKEPGPRQHAPKPPSPKPDGDREGRGSEEATEVSHIKRKEVTRTVVSKAYERGGDVNYLSHRYEHDGGVSEAVQPDNDIDRILLSHDSPTRRRKCTNLVSELTKGWKVMEQEEPKWKSDSIDTEDSGYGGDMEERPEQDVAQVAAARIKRPLHSQANRYSETLNCKAHRKYSQVDNLKGRWQQWADEHIQSQKLNPFSDEFDYDLAMSTRLHKGDEGYGRPKEGSKTAERAKRAEEHIYREIMELCFVIRTMARHRRDGKIQVTFGELFDRYVRISDKVVGILMRARKHGLVHFEGEMLWQGKDDHVVITLLE
What is the function of this protein?
Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
What are the official names of this protein?
Actin-binding Rho-activating protein, MS1, Striated muscle activator of Rho-dependent signaling, STARS.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z- lines.
Protein: RL21_PSEPG
Sequence: MSYAVIVTGGKQYKVAEGEFLKIEKLEVATGESVTFDRVLLVANGEEVTIGAPVVAGAKVVAEVVSQGRHDKVRIIKFRRRKHHMKRMGHRQWFTEIKITGIQA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: CD86_RABIT
Sequence: MDAGCTMGLSVTVFVMALLLSGAASLRIQAYFNKTADLPCQFTNSQSRSLSELVVFWQDQERLVLYELFLGREKPDNVDPKYIGRTSFDQESWNLQLHNVQIKDKGVYQCFVHHRGAKGLVPIYQMNSELSVLANFTQPEITLISNITRNSAINLTCSSVQGYPEPKKMFFVLKTENATTEYDGVIEKSQDNVTGLYNISISGSITFSDDIRNATIYCVLQTESTETYSQHFPIVPADPVPVEKPRLWIAAVALTLIVVCGIVLFLTLWKRKKEQQPGVCECETIKMDKAENEHVEERVKIHEPEKIPAKAAKCEHRLKTPSSDKSAAHF
What is the function of this protein?
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4.  May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation.  Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced.  Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
What are the official names of this protein?
T-lymphocyte activation antigen CD86, Activation B7-2 antigen.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: GLMU_STRS2
Sequence: MSNNYAIILAAGKGTRMKSDLPKVLHKVAGITMLEHVKRAVDAMEPAKTVTIVGHKAELVQAVLEGQSEFALQSEQLGTGHAVMMAEPALAGLEGQTLVIAGDTPLITGESLKNLINFHVSHKNVATILTAQADNPFGYGRIIRNADGEVQKIVEQKDANDFEKQVKEINTGTYLFDNKRLFEALKDINTDNAQGEYYLTDVISIFRQAGEKVGAYVLRDFDESLGVNDRVALATAEAVMRKRINEKHMVNGVTFINPDATYIDIDVEIGAEAVIEANVVLKGQTVIGERTVLTNGTRVRDAKIAADAVISNSDIEESVIEEGVTVGPYAHIRPGSLLKKDVHVGNFVEIKASTLGQGTKSGHLTYLGNATIGNNVNVGAGTITVNYDGKNKFKTTVGDNAFVGSNSTIIAPVTIGDNALLAAGSVITKDIPEDAIGIGRGRQENKEGYATRFPFHPSQK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCME_WOLPM
Sequence: MKKKHKRLLITSGIFCFLSCAVFFILTTLKENISFFYTVSEAIVLPNGQKLIRVGGMVVENSVIRNESEVIFQMTDFNKSVMVKYQGILPPMFSEKSGVVVQGKMFDNSTFLADTVFAKHDENYMPKVLK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: KEFB_ECOUT
Sequence: MEGSDFLLAGVLFLFAAVAAVPLASRLGIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKLWQLRRSIFGVGAAQVLLSAALLAGLLMLTHFSWQAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDLAVIPALALVPLLAGSADEHFDWMKIGMKVLAFVGMLIGGRYLLRPVFRFIAASGVREVFTAATLLLVLGSALFMDALGLSMALGTFIAGVLLAESEYRHELETAIDPFKGLLLGLFFISVGMSLNLGVLYTHLLWVVISVVVLVAVKILVLYLLARLYGVRSSERMQFAGVLSQGGEFAFVLFSTASSQRLFQGDQMALLLVTVTLSMMTTPLLMKLVDKWLSRQFNGPEEEDEKPWVNDDKPQVIVVGFGRFGQVIGRLLMANKMRITVLERDISAVNLMRKYGYKVYYGDATQVDLLRSAGAEAAESIVITCNEPEDTMKLVEICQQHFPHLHILARARGRVEAHELLQAGVTQFSRETFSSALELGRKTLVTLGMHPHQAQRAQLHFRRLDMRMLRELIPMHADTVQISRAREARRELEEIFQREMQQERRQLDGWDEFE
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefB, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL36_SHESR
Sequence: MKVRASVKKICRNCKIVKRSGVVRVICVEPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: GDPD4_MOUSE
Sequence: MEETQDSSSSKPKNTDENFSLWIEQYFNHKCCITFLTGCYSCQWQYREWEKTELGSCCCSRKEQFFYMCLVIAFILSVLFLFVWVETSNEYNGFDWVVYLGTGCWFFWSILVLSAAGIMVAYTTLLLLLGFLLLWERIELNLHTSHKVFICLVIVLCSFLLAVLSHFWKDKWLIAGLSLQIFAPFVHLSLITVMIIISWPLSICVARLESEVKVRRYRMADYEQEIQERCNVFQRLRALQIAAGLSFLIILLCLYLMPLGIYSPCILKKENLGPKPTLFGHRGAPMLAPENTMMSFEKAVELDVSGLETDIYLSFDSVPFLMHDYDLTRTTNIKEVLPSAAGNHTSNFNWTFLSTLNAGKWFLKHKPFFGMKPLSEADKRRAGNQSIPQLSELLALAKREQKIVIFDLFGPRPGHPLRNTFVRRVVKVILDSKIEQRLIFWLPGFDRDYVRFMAPGFQHVGRLWSIKDLTKHNITIINVDYKRLFYAGLRDYKEAKIYIHVYVINEPWLFSLAWCSSINSVTTDNIELLNQLSRPLFFMTPGFYMFMWLFLDIASAVIIGFVFCYNWIKEIKRERWLEAAASSGLLHSETITDITENNDASQQKPEVAPTSANLAPENMIELQKTEPKTENL
What are the official names of this protein?
Glycerophosphodiester phosphodiesterase domain-containing protein 4, Glycerophosphodiester phosphodiesterase 6.
What is the protein family that this protein belongs to?
Belongs to the glycerophosphoryl diester phosphodiesterase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Multi-pass membrane protein.
Protein: HDA_ECO57
Sequence: MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: IHFA_SALCH
Sequence: MALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPKEE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RL27_PSYIN
Sequence: MAHKKAGGSTNNGRDSESKRLGVKRFGGESVLAGNILVRQRGTKFHAGINVGIGKDHTLFAKATGVVKFEKKGPKMRSFITIVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SODM_SAPAP
Sequence: KHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNDTEEKYKEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKERLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn], mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PDE9A_HUMAN
Sequence: MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
What is the function of this protein?
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.  Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814).  Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle.  Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991).  Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable).  In brain, involved in cognitive function, such as learning and long-term memory (By similarity).
What are the official names of this protein?
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.
What are the subcellular locations of this protein?
[Isoform PDE9A1]: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum. Cell membrane, sarcolemma. SUBCELLULAR LOCATION: [Isoform PDE9A2]: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. SUBCELLULAR LOCATION: [Isoform PDE9A3]: Cytoplasm. Endoplasmic reticulum. SUBCELLULAR LOCATION: [Isoform PDE9A17]: Cytoplasm. Endoplasmic reticulum.
Protein: SYT_MYCGI
Sequence: MSAPARPAPAAPIRVTAGTTAGQAVRDAGLPSRGAPDAVVVVRDADGRLRDLSWVPDTDVEVTPVAADTEDGRSVIRHSAAHVLAQAVQEMFPDAKLGIGPPITDGFYYDFDVAEPFTPEHLQALEKKMRKIVKDGQIFERRVFGSKDEARAELASEPYKLELIDDKSGADDPEVMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTRYIPAFTLTRSSAAYWRGDQNNASLQRIYGTAWESQEALDRHLELIEEAQRRDHRKLGVELDLFSFPDELGSGLPVFHPKGGVVRRELEEYSRRKHIEAGYEFVNTPHITKEQLYITSGHLEWYADGMFPPMQIDAEYNEDGTVRKPGQDYYLKPMNCPMHHLIYRSRGRSYRELPLRLFEFGSVYRYEKSGVIHGLTRVRGMTQDDAHIYCTREEMRDELARLLQFVLDLLADYGLDDFYLELSTKDPDKFVGSDDLWEEATETLREVAESSGLALVPDPGGAAFYGPKISVQVRDALGRNWQMSTIQLDFNMPDRFELEYTSSDGTRRRPVLIHRALFGSIERFFGVLTEHYAGAFPVWLAPVQVVGIPVADAHAGYLDGVAAELRRRGIRVEVDASDDRMAKKIVNHTNQKVPFMLLAGDKDVEAGAVSFRFGDRTQINGVPRDQAVEAIVDWVNRRENATPTAELVVLPSGDAQSPVAGEG
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 7OMT_PAPSO
Sequence: MDTAEERLKGQAEIWEHMFAFVDSMALKCAVELGIPDIINSHGRPVTISEIVDSLKTNTPSSSPNIDYLTRIMRLLVHKRLFTSELHQESNQLLYNLTRSSKWLLKDSKFNLSPLVLWETNPILLKPWQYLGKCAQEKSSPFERAHGCEIWDLALADPKFNNFLNGAMQCSTTTIINEMLLEYKDGFSGIAGSLVDVGGGTGSIIAEIVKAHPHIQGINFDLPHVVATAAEFPGVKHVGGDMFVDIPEADAVIMKWILHDWSDEDCTIILKNCYRAIRKKKNGKVIIVDCVLRPDGNDLFDKMGLIFDVLMMAHTTAGKERTEAEWKILLNNAGFPRYNVIRTPAFPCIIEAFPE
What is the function of this protein?
Catalyzes the transfer of a methyl group to reticuline to form laudanine.  Methylates the simple catechols guaiacol and isovanillic acid as well as the tetrahydrobenzylisoquinolines (R)-reticuline, (S)-reticuline, (R,S)-orientaline, (R)-protosinomenine and (R,S)-isoorientaline.  Involved in the production of laudanine.
What are the official names of this protein?
(R,S)-reticuline 7-O-methyltransferase, 7OMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.