PharMolix/UniProtQA huggingface dataset:
Protein: KTHY_PROM1
Sequence: MKGKFIVFEGIDGSGKTTQINQLSKWLISTDLIPENNKLVITREPGGTQLGKSIRSLLLDTSIEKSPDSITELLLYAADRSQHVNEIIRPTLDQGDWVISDRFCGSTLAYQGYGRKLDITLIKDLEAIATQGIAPDITFLLDIPIEESIRRRRNRKDDRIEKEGREFLSNVSLGFQALSEDSHWKKISAIDSKEKIISEIKSEIKKLIKNK
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: DYL2_MOUSE
Sequence: MSDRKAVIKNADMSEDMQQDAVDCATQAMEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
What are the official names of this protein?
Dynein light chain 2, cytoplasmic, 8 kDa dynein light chain b, DLC8, DLC8b, Dynein light chain LC8-type 2.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: LGT_RICTY
Sequence: MILPNINPIIFSIGPFSISWYSLSYVVGILLGWFYATKIIEKFKPEITKKHIEDFITYAIIGIIVGGRLGYVLLYNPLKYFANPIEILKTYEGGMSFHGATIGIIISAYLFCQKYKINFLSLTDIITTVVPIGLFLGRIANFINCELYGRITNSSFGIIFPNSDLEPRHPSQLYEAFFEGLILFCILAYAVFRHDTLKKQGLNSGIYLIFYSLFRIIIEMFREPDIQIGFILDSLTMGQILSAPMLLLGSYLICRLNSK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBE2S_DROMO
Sequence: MSSQYSNVENLSPQTIRQVMKELQDMETTPPEGIKVLINESDVTDIQALIDGPAGTPYAVGIFRVKLTLSKDFPQTPPKAYFLTKIFHPNVAANGEICVNTLKKDWKPDLGIKHILLTIKCLLIVPNPESALNEEAGKMLLERYDDYSQRARMMTEIHAQPVKCGVSDAKDDDGPSNKKHAGLDKKLQDKKKEKLLKEKKRMLKRL
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.  Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 S, E2 ubiquitin-conjugating enzyme S, Ubiquitin carrier protein S, Ubiquitin-protein ligase S.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: CLPX_BAUCH
Sequence: MTDKHKDSSKQFLYCSFCSKKQHEVRKLIAGPSVCICDECVNLCNDIIREEIKDVVKNSDIQILPTPHDINNHLNNYVIGQEQAKKVLAVAVYNHYKRLHHDTSHNNVELGKSNILLIGPTGSGKTLLADTLARFLHVPFTMADATTLTEAGYVGEDVENILHQLLQKCDYNVQKAQHGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPHGGRKHPQQDFLKVDTSKILFICGGAFDGLDKVIERRMDTNNSIGFSAIIKLGSDQLNEDKLLTQVEPEDLVKFGLIPEFIGRLPVVATLNELSEEALIRILREPKNALTKQYQALFNLEGVELEFSEEALIAIAKKAMARKTGARGLRSIVEGILLETMYELPSQLHVEKVIINEAVITSNTKPKIIYREPDNKVS
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RNPA_PASMU
Sequence: MIKLNFSRELRLLTPLHFKYVFEQPFRASTPELTILARPNNLAHPRLGLTVAKKHLKKAHDRNRIKRLCRESFRLAQYKLPNCDFVIVAKQGIGKLDNRTLTQTLDKLWQRHIRLAQKS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: HTPG_FRAT1
Sequence: MSEKKYTFETEVDKLLHLVIHSLYSNREIFLRELVSNSSDAIEKLRYESISNAALNEDDTDYAIRIDFDKDAKTITVSDNGIGMTEEEVIENLGTIAKSGTKKFLESLTGDKSKDNELIGQFGVGFYSSFIVADKVTVRTRKAGQDKSQATKWVSDAQNGFTVETITKEKRGTEVILHIKKEHLDLLEYHVLKGLVNKYSDCINTSIQMKKVEYDKDGKQTVKDEYETVNNTKAIWLRSKDEVTDEEYQEFYKYISHDFADALMWIHNKVEGNLEYNSLLYIPQNKPFDFWNRDKDYGLSLYVRRVFIMENKELLPPYLRFVKGVIDSADLPLNVSREILQHNKVIDKIKKAITTKILSELKKLASKDKEKYQKFWDSFGQVLKEGVSDDYSNKEKIAGLLRFATTQSGDSKQTVSLADYISRMKEGQDTIYYITSDSYKAAANNPQLEAFKKKGIEVILMTDRIDEWMMSTLTEFDGKHMKSIIKGDIDLDRFETPENKEKFEKEAKDFEKVLKEIKEVLKDKVEDVRLSKRLTDSPSCVVVNDYGMSLHMQKMMEEAGQSFMPGMGMKPILELNAEHNLVQKLKNEADTEIFADLSELLLLQAMFVEGAKIEDPMAFVKLVNKYIR
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS182_SACEN
Sequence: MAKAPVRKPKKKVCVFCKDKAAQSIDYKDTTLLRKYISDRGKIRARRVTGNCSQHQRDVAIAVKNAREMALLPYTSTAR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RS7_CLOD6
Sequence: MPRKGNIPKREVLPDPMYGSKVVTKLINNLMVDGKKGKSQRIVYDAFAIVAEKTGEEALEVFNKAMDNIMPVLEVKARRVGGANYQVPIEVRPERRQTLGLRWLVKYTRARGEKGMVEKLAKEIMDAANNTGASVKKKEDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: PHZF_PSECL
Sequence: MHHYVIIDAFASAPLEGNPVTVFFDADDLSATQMQRIAREMNLSETTFVLKPRNCGDALIRIFTPVNELPFAGHPLLGTAIALGAHTDNHRLFLETQMGTIAFELERQNGSVVAASMDQPIPTWTALGRDVELLKALGISDSTFPIEIYHNGPRHVFVGLPSIAALSALHPDHRALSSFHDMAINCFAGAGRRWRSRMFSPAYGVVEDAATGSAAGPLAIHLARHGQIEFGQQIEILQGVEIGRPSLMFARAEGRADQLTRVEVSGNGVTFGRGTIVL
What is the function of this protein?
Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system.  The final product is not yet known.
What are the official names of this protein?
Trans-2,3-dihydro-3-hydroxyanthranilate isomerase, Phenazine/pyocyanine biosynthesis protein PhzF.
What is the protein family that this protein belongs to?
Belongs to the PhzF family.
Protein: PHNC_HYPNA
Sequence: MTDEPALESAALPVLCLENTSAVYAGGVVALSRFNLEVQAGEFCVILGPSGSGKSTLLRLISGLVPTSSGTVTIGGIKMAPPTRRKARQRLGMVHQDHGLIDRLSVLDNVMAGCAGSLPFWRLMLRMYPRPVVDAACQLLDEVGLTEAQANRRARELSGGQRQRVGIARALMGTPLLILADEPVASLDPQTSRIILALLRRAAKDRGIAVLCSLHQMDLAREFADRIVVMRNGRPVFNDCPAELSGFLERSAIPPKRSGAA
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MINE_PSEA7
Sequence: MSLLDFFRSRKSQNSASIAKERLQIIVAHERGQRAQPDYLPQLQKDLLEVIRKYVPIDQEQIQVELENQGNCSILELNITLPDR
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RHO_MYCBO
Sequence: MTDTDLITAGESTDGKPSDAAATDPPDLNADEPAGSLATMVLPELRALANRAGVKGTSGMRKNELIAAIEEIRRQANGAPAVDRSAQEHDKGDRPPSSEAPATQGEQTPTEQIDSQSQQVRPERRSATREAGPSGSGERAGTAADDTDNRQGGQQDAKTEERGTDAGGDQGGDQQASGGQQARGDEDGEARQGRRGRRFRDRRRRGERSGDGAEAELREDDVVQPVAGILDVLDNYAFVRTSGYLPGPHDVYVSMNMVRKNGMRRGDAVTGAVRVPKEGEQPNQRQKFNPLVRLDSINGGSVEDAKKRPEFGKLTPLYPNQRLRLETSTERLTTRVIDLIMPIGKGQRALIVSPPKAGKTTILQDIANAITRNNPECHLMVVLVDERPEEVTDMQRSVKGEVIASTFDRPPSDHTSVAELAIERAKRLVEQGKDVVVLLDSITRLGRAYNNASPASGRILSGGVDSTALYPPKRFLGAARNIEEGGSLTIIATAMVETGSTGDTVIFEEFKGTGNAELKLDRKIAERRVFPAVDVNPSGTRKDELLLSPDEFAIVHKLRRVLSGLDSHQAIDLLMSQLRKTKNNYEFLVQVSKTTPGSMDSD
What is the function of this protein?
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
What are the official names of this protein?
Transcription termination factor Rho, ATP-dependent helicase Rho.
What is the protein family that this protein belongs to?
Belongs to the Rho family.
Protein: 3SX3_MICAT
Sequence: MRTLLLTLVVVTIVCLDLGNSLICYVSEYGAKMTCPEGKTLCEKYAVPLMQGHFYFAWRCTSTCKAGAYNICCSTDLCNKIP
What are the official names of this protein?
Three-finger toxin MALT0063C, 3FTx MALT0063C.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EASD_ARTBC
Sequence: MASVSSKIFAITGGASGIGAATCRLLAKRGAATLCVGDLCSENMKQLENDIKEINPNTKVHCTVLDVSSSSNVDEWIKDIITTFGDLHGAANIAGIAQGAGLRQAPTILEEDDQQWKKVFQVNLDGVLYSTRAQVRAMKESSSTNPGDRSIVNVASIASMSHMPDVFAYGTSKAGCAYFTTCVSQDVMPFGIRANTVSPEEVEETYKKEGFSVIEADDVARTIVWLLSEDSRPVFGANINVGACMP
What is the function of this protein?
Chanoclavine-I dehydrogenase; part of the gene cluster that mediates the biosynthesis of fungal ergot alkaloid (PubMed:22403186).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:22403186).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (PubMed:22403186).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by easD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:22403186).  Chanoclavine-I aldehyde is the precursor of ergoamides and ergopeptines in Clavicipitaceae, and clavine-type alcaloids such as fumiclavine in Trichocomaceae (PubMed:22403186).  However, the metabolites downstream of chanoclavine-I aldehyde in Arthrodermataceae have not been identified yet (PubMed:22403186).
What are the official names of this protein?
Chanoclavine-I dehydrogenase easD, ChaDH, Ergot alkaloid synthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: BCSA1_KOMXY
Sequence: MSEVQSPVPAESRLDRFSNKILSLRGANYIVGALGLCALIAATTVTLSINEQLIVALVCVLVFFIVGRGKSRRTQIFLEVLSALVSLRYLTWRLTETLDFDTWIQGGLGVTLLMAELYALYMLFLSYFQTIQPLHRAPLPLPDNVDDWPTVDIFIPTYDEQLSIVRLTVLGALGIDWPPDKVNVYILDDGVRPEFEQFAKDCGALYIGRVDSSHAKAGNLNHAIKRTSGDYILILDCDHIPTRAFLQIAMGWMVADRKIALMQTPHHFYSPDPFQRNLAVGYRTPPEGNLFYGVIQDGNDFWDATFFCGSCAILRREAIESIGGFAVETVTEDAHTALRMQRRGWSTAYLRIPVASGLATERLTTHIGQRMRWARGMIQIFRVDNPMLGGGLKLGQRLCYLSAMTSFFFAIPRVIFLASPLAFLFFGQNIIAASPLAVLAYAIPHMFHSIATAAKVNKGWRYSFWSEVYETTMALFLVRVTIITLMFPSKGKFNVTEKGGVLEEEEFDLGATYPNIIFAGIMTLGLLIGLFELTFHFNQLAGIAKRAYLLNCIWAMISLIILLAAIAVGRETKQVRYNHRVEAHIPVTVYEAPVAGQPNTYHNATPGMTQDVSMGGVAVHMPWPDVSTGPVKTRIHAVLDGEEIDIPATMLRCKNGKAVFTWDNNDLDTERDIVRFVFGRADAWLQWNNYEDDRPLRSLWSLLLSIKALFRKKGKMMANSRPKRKPLALPVERREPTTIQSGQTQEGKISRAAS
What is the function of this protein?
Catalytic subunit of cellulose synthase.  It polymerizes uridine 5'-diphosphate glucose to cellulose in a processive way.  The thick cellulosic mats generated by this enzyme probably provide a specialized protective environment to the bacterium.  Binds c-di-GMP with a dissociation constant of 30 uM.
What are the official names of this protein?
Cellulose synthase catalytic subunit [UDP-forming].
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COPD2_ORYSJ
Sequence: MVVLAASIISKSGKALVSRQFVDMSRIRIEGLLAAFPKLVGTGKQHTYVETENVRYVYQPIEGLYLLLITNKQSNILEDLDTLRLLSKLVPEYSPSLDEEGVCKTAFELIFAFDEAICLGNKENVTVQQVKQYCEMESHEEKAHKLMMQSKINETRDVMKKKASELDKMKMERGKLDKGGYSAISGPRVVEKAFGDMSITGSGFGSGSGLGGLSMDMDSFASKPKGRPSAAATAPGKGLGMKLGKTQKTNQFLESLKAEGEVILEDVQPSSVQSRVSPLPPSDPVTVTIEEKLNVTVKRDGGVNNFDVQGTLALQVLNDTDGFIQLQIENQDVPGLSFKTHPNINKDLFNSQQVVGAKDPNRPFPSGQNETPLVKWRIHGMDESSLPLSVNCWPSVSGNETYVNIEYEAAEMFDLHNVVISIPLPALREAPSVRQIDGEWRYDSRNSVLEWSILLIDQSNRSGSMEFVVPPADPSTFFPISIGFSASSTFSDLKVTGIRPLKDGNPPKYSQRARLVTANYQVV
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit delta-2, Delta-coat protein 2, Delta-COP 2.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: IF1_TROW8
Sequence: MAKKDGVIELEGSVLEALPNATFRVELSNGHKVLAHISGRMRQHYIRILPEDRVVVELSPYDLARGRIVYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RH48_ORYSJ
Sequence: MGGGPRTFPGGLSKWQHKRMHEKLARHKERGLLRHEKQLYLARLRSEIRASRLPAAGASPPDDGDGPTSSRAHIRALADRFLLPGAEDLWNEDDGPIHRADRPRPPRRIVSVGGNGGDRRKLDSTKQELPRGGKEPRLAAFNPRRDFQTAAPWWWQWSSSSAIPSRTKEASFCFFGPKRSYSVMPLFQAHQESSGTSMVPLIARGLASARIAPSQLNGERFYSFAAGRFGRKLRPDSSDEDDEDISTAKKDMRFARFGASSEEESGYDELEARSAIRKKWSSAALRNCDMKKERRALKSYEEENNDLAGSFRELREEIKNREVLGAERRRYESRGESLFTNKRFEECGISPLTVKALTDAGYVQTTVVQETALPMCLEGKDVLVKAKTGTGKSAAFLLPAIESVLNAMKSHTNHRVSPIFSLILCPTRELAIQLTAEANVLLKYHQGIGVQSLIGGTRFKLDQRRLESDPCQILVATPGRLLDHIENKSSFSVRLMGLKLLVLDEADHLLDLGFRTDIEKIVDSLPRQRQTLLFSATIPKEVRRVSQLVLKRDHVFVDTVGLGAVETPTKVEQLYLVMPHELHFHMVYRLLREHIDQEVDYKVIVFCTTAMVTEFMYIMLRDLKLNVREIHSRKPQLYRTRISEEFRDSSRLILVTSDVSTRGVNYPGVTLVIQVGVPSDREHYIHRLGRTGREGKSGKGILLLAPWEEYFLNEIHDLPVQKSQTPNIDEEMKRKVDGSIKIVDMSIKEAAYHAWLGYYNSIGDVGRDKTMLVDLANRFCKSIGLEKPPALYRKTALKMGLKDVPGIRIRK
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 48.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family.
Protein: PURA_PARXL
Sequence: MSASAVNVNPGRNVVVVGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKTILRLIPSGIMHPGVACYIGNGVVLSPEALFKEIGELEAAGVDVQNRLFISEATTLILPYHIAIDQGREARRGAGKIGTTGRGIGPAYEDKVARRGLRVQDLFEPEIFAERLRENLDYHNFVLTQYLGVAAVDFQQTLDTMLSYADRLRPMVTDVSRRLYDVNAAGSNLLFEGAQGTLLDIDHGTYPFVTSSNCVAGAATAGAGVGPQKLNYILGITKAYCTRVGSGPFPSELYDADNAARQEAIGLELATVGKEFGSVTGRPRRTGWLDAAALRRSIQINGVSGLCMTKLDVLDGLDEVKLCVGYKVDGKNVDLLPRGASEVARCEPVYETFAGWKESTVGIKEWDKLPANARAYLSRVQEVAGIPIDMVSTGPDRDETILLRHPFKV
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P66B_MOUSE
Sequence: MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLKRKDLANLEVPHELPTKQDGSGVKGYEEKLNGNLRPHGDNNRTAGRPGKENINDEPVDMSARRSEPDRGRLTPSPDIIVLSDNEASSPRSSSRMEERLKAANLEMFKGKGMEERQQLIKQLRDELRLEEARLVLLKKLRQSQLQKENVVQKTPVVQNAASIVQPSPAHVGQQGLSKLPSRPGAQGIEPQNMRTLQGHSVIRSATNTTLPHMLMSQRVIAPNPAQLQGQRGPPKPGIVRTTTPNMNPAISYQPQSSSSVPCQRTTSSAIYMNLASHIQPGTVNRVSSPLPSPSAMSDAANSQAAAKLALRKQLEKTLLEIPPPKPPAPLLHFLPSAANSEFIYMVGLEEVVQSVIDSQGKNCASLLRVEPFVCAQCRTDFTPHWKQEKNGKILCEQCMTSNQKKALKAEHTNRLKNAFVKALQQEQEIEQRLQQQAALSPTTAPAVSSVSKQETIMRHHTLRQAPQPQSSLQRGIPTSARSMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHKAPSLADRQREYLLDMIPPRSISQSISGQK
What is the function of this protein?
Transcriptional repressor.  Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin.  Enhances MBD2-mediated repression.  Efficient repression requires the presence of GATAD2A.  Targets MBD3 to discrete loci in the nucleus.  May play a role in synapse development.
What are the official names of this protein?
Transcriptional repressor p66-beta, GATA zinc finger domain-containing protein 2B, p66/p68.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Speckled nuclear localization requires both CR1 and CR2 regions.
Protein: CBHB_ASPTN
Sequence: MPSTYDIYKKLLLLASFLSASQAQQVGTSKAEVHPSLTWQTCTSGGSCTTVNGKVVVDANWRWVHNVDGYNNCYTGNTWDTTLCPDDETCASNCALEGADYSGTYGVTTSGNSLRLNFVTQASQKNIGSRLYLMEDDSTYKMFKLLNQEFTFDVDVSNLPCGLNGAVYFVSMDADGGMAKYPANKAGAKYGTGYCDSQCPRDLKFINGMANVEGWEPSANDANAGTGNHGSCCAEMDIWEANSISTAYTPHPCDTPGQVMCTGDSCGGTYSSDRYGGTCDPDGCDFNSYRQGNKTFYGPGMTVDTKSKITVVTQFLTNDGTASGTLSEIKRFYVQNGKVIPNSESTWSGVSGNSITTAYCNAQKTLFGDTDVFTKHGGMEGMGAALAEGMVLVLSLWDDHNSNMLWLDSNYPTDKPSTTPGVARGSCDISSGDPKDVEANDANAYVVYSNIKVGPIGSTFSGSTGGGSSSSTTATSKTTTTSATKTTTTTTKTTTTTSASSTSTGGAQHWAQCGGIGWTGPTTCVAPYTCQKQNDYYSQCL
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Probable 1,4-beta-D-glucan cellobiohydrolase B, Beta-glucancellobiohydrolase B, Exocellobiohydrolase B, Exoglucanase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ABDH_SHIF8
Sequence: MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEVSAEQVDAAVRAADAAFAEWGQTTPKARAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: ADRB3_BOVIN
Sequence: MAPWPPGNSSLTPWPDIPTLAPNTANASGLPGVPWAVALAGALLALAVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGVTGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRALAAVVLVWVVSAAVSFAPIMSKWWRIGADAEAQRCHSNPRCCTFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRRELGRFPPEESPPAPSRSGSPGLAGPCASPAGVPSYGRRPARLLPLREHRALRTLGLIMGTFTLCWLPFFVVNVVRALGGPSLVSGPTFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCRPEEHLAAASPPRAPSGAPTALTSPAGPMQPPELDGASCGLS
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  Beta-3 is involved in the regulation of lipolysis and thermogenesis.
What are the official names of this protein?
Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARGJ_ASPTN
Sequence: MAVFARMVKGQVRHYSAPVDMAIPASKRKFIPSSGSYPKGFLVSGTHVGVKASNTKFPDLALISSETPCSAAAVFTTNKFQAAPVQVSRDILKTRQGHGIRSVVINSGCANAVTGKGGLEDAVAMGKKVDECNGLNEPSTLVMSTGVIGQRLPISKILNNIPAAHTNLSSTHDAWLSTARAICTTDTFPKLLSRTFTLPSSPERTYRLAGMTKGAGMIHPNMATLLGVLCTDAPVEPSALQSLLKYAVARSFNSISIDGDTSTNDTVAILANGAAGGAPVTSSAASPDYTALQDILTSFTQSLSQLVVRDGEGATKFVTVRVQNSPHYESARLIASTIARSPLVKTALYGRDANWGRILCAIGYTQGVAPGTVVPERTSVSFKPVDGSPILKLLVNGEPEQVDEERASVILQEEDLEIVVDLGGGEKGEQGLGGEEAVYWFCDFSHEYVTINGDYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.