Protein: DDX6_DROME
Sequence: MMTEKLNSGHTNLTSKGIINDLQIAGNTSDDMGWKSKLKLPPKDNRFKTTDVTDTRGNEFEEFCLKRELLMGIFEKGWERPSPIQEAAIPIALSGKDVLARAKNGTGKTGAYCIPVLEQIDPTKDYIQALVMVPTRELALQTSQICIELAKHLDIRVMVTTGGTILKDDILRIYQKVQLIIATPGRILDLMDKKVADMSHCRILVLDEADKLLSLDFQGMLDHVILKLPKDPQILLFSATFPLTVKNFMEKHLREPYEINLMEELTLKGVTQYYAFVQERQKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITELGYCCYYIHAKMAQAHRNRVFHDFRQGLCRNLVCSDLFTRGIDVQAVNVVINFDFPRMAETYLHRIGRSGRFGHLGIAINLITYEDRFDLHRIEKELGTEIKPIPKVIDPALYVANVGASVGDTCNNSDLNNSANEEGNVSK
What is the function of this protein?
ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission (PubMed:11546740, PubMed:16256742, PubMed:17178403, PubMed:18590813, PubMed:21267420, PubMed:21447556, PubMed:28875934, PubMed:28388438, PubMed:17982591, PubMed:31114929).  Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies (PubMed:28875934, PubMed:11546740, PubMed:16256742, PubMed:17178403, PubMed:21267420, PubMed:21447556, PubMed:17982591).  As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogenesis (PubMed:28875934).  As part of a RNP complex containing tral and the RNA localization factors exu and yps, mediates translational silencing of mRNAs such as osk/oskar and bcd/bicoid during their transport to the oocyte in order to prevent their translation until they reach their positional destinations (PubMed:11546740).  In neurons and possibly imaginal disks, involved in miRNA-mediated translational repression, possibly in association with components of the piRNA transposon silencing pathway (PubMed:21447556, PubMed:17178403, PubMed:21267420, PubMed:17982591, PubMed:21081899).  Involved in RNA localization and protein trafficking in the oocyte (PubMed:11546740, PubMed:16256742).  As part of an ER-associated RNP containing tral, cup and yps, required for tral-dependent ER exit site formation and consequently efficient trafficking of proteins such as grk and yl through the secretory pathway (PubMed:16256742).  Component of neuron RNPs that mediate transport and translation of neuronal RNAs, including translation repression of synaptic transcripts in preparation for their dendritic targeting (PubMed:17178403, PubMed:21267420, PubMed:28388438).  As part of the Atx2-Not1 repressor complex promotes Not1-dependent post-transcriptional gene silencing in adult circadian pacemaker neurons in order to sustain high-amplitude circadian rhythms and Pdf cycling in a per-independent manner (PubMed:28388438).  Promotes the interaction between Atx2 and Not1 within the Atx2-Not1 RNP complex (PubMed:28388438).  Recruited to the 4EHP-GYF2 complex by Gyf, where it plays a role in 4EHP-GYF2 mediated translational repression and mRNA decay (PubMed:31114929).
What are the official names of this protein?
ATP-dependent RNA helicase me31b, Maternal expression at 31B.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, P-body. Endoplasmic reticulum. Cell projection, dendrite. Note=Component of a variety of germ granule ribonucleoprotein complexes (RNPs) including the nuage of nurse cells, sponge bodies of nurse cells and early egg chambers in oocytes, as well as polar granules in the germ plasm at the posterior pole of mid-late stage oocytes and in early embryos (PubMed:11546740, PubMed:18590813, PubMed:21447556, PubMed:28945271, PubMed:21267420). Component of an RNP that localizes to discrete subdomains of the ER cytoplasmic surface (PubMed:21267420, PubMed:16256742). Also present in cytoplasmic granules in the cell bodies and neuropil area of the antennal lobes (PubMed:21267420). In the olfactory sensory and projection neurons, granules appear to predominately localize to postsynaptic dendrites (PubMed:21267420).