PharMolix/UniProtQA huggingface dataset:
Protein: DCTA_ECOLC
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRAPDGKTHELSS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLF16_ARATH
Sequence: MVAYEKSPIVFLFATMMLVMFLFCGSGEARTLGYGSIKGDRIPACGYKNPNSCVKQPVNHYHRGCEKITRCARDAARYTESFNVDDDESPIINLH
What is the function of this protein?
Cell signaling peptide that may regulate plant stress, growth, and development.  Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
What are the official names of this protein?
Protein RALF-like 16.
What is the protein family that this protein belongs to?
Belongs to the plant rapid alkalinization factor (RALF) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNTAC_BURSR
Sequence: MRQAIMSYQNLVSEAGLTQKHLIYGDKELFQHELKTIFARNWLFLTHDSLIPSPGDYVKAKMGVDEVIVSRQNDGSVRAFLNVCRHRGKTIVDAEAGNAKGFVCGYHGWGYGSNGELQSVPFEKELYGDAIKKKCLGLKEVPRIESFHGFIYGCFDAEAPPLIDYLGDVAWYLEPTFKHSGGLELVGPPAKVVVKGNWKVFAENFVGDIYHIGWTHASILRAGQAIFAPLAGNAMLPPEGTGLQATTKYGSGIGVSLDAYSGVQSADLVPEMMAFGGAKQEKLAKEIGDVRARIYRSQVNGTVFPNNCFLTGAGVFKVFNPIDENTTEAWTYAIVEKDMPEDLKRRLADAAQRSTGPAGYWESDDNDNMVLSQNAKKYQSSNSDLIADLGFGKDVYGDECYPGVVSKSAFSETNHRGFYRAYQAHISSSNWAEFENTSRNWHTELTKTTDR
What is the function of this protein?
Component of the 2,4-dinitrotoluene dioxygenase (DNTDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into 2,4-dinitrotoluene (DNT) to form 4-methyl-5-nitrocatechol (MNC) and nitrite.  The alpha subunit has a catalytic role in the holoenzyme.  Also able to convert naphthalene to cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene.
What are the official names of this protein?
2,4-dinitrotoluene dioxygenase system, large oxygenase component, 2,4-dinitrotoluene dioxygenase ISP alpha, 2,4-dinitrotoluene dioxygenase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.
Protein: TX24A_LYCSI
Sequence: MSPKVQALLLLVGLITFLAVHAEEELSETVESERSCAKEYQWCDWNTRPCCDNISCICSWIGTNCECKKGIIRTIKDWYKGK
What are the official names of this protein?
U16-lycotoxin-Ls1a, U16-LCTX-Ls1a, Toxin-like structure LSTX-P1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 02 (plectoxin) family. 04 (U16-lycotoxin) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYL_HERA2
Sequence: MATRYDSSITEPKWRERWERDGIYRFEPDSDKPKHYAVTMLPYPSGNLHIGHWYAMSPSDVHARYMRMRGYNVFFPMGFDAFGLPAENAAIKNNLDPRKWTYSNIEYMRGQLQSMGMMVDWDQQIVSADPEYYRWNQWFFIQFFKRGLAYKKFSAVDWCPKCNTTLAREQVVGDERRCERCDSLVTKRDLDQWYFKITSYADELLNFSELDWPERITTMQRNWIGRSEGAEISFKSEAGDPITVFSTRPDTLWGATFMVLAPEHPLVAKLTSAEQKASVDAYVAEAIRKTEVERQSTDDEKPKTGVWIGAYAINPASQERVPIWIADYVLMTYGTGAIMAVPGHDERDFAFAKTFGLAIKRVVTQSEQTAETPLEAAEPAYGTVVNSGQIDGLSSAEAKEAVINWLEAEQLGKRAINYRLRDWLVSRQRYWGTPIPMIYCPTCGTVPVPEDQLPLLLPDSVDFKPTGESPLKLHPTWRFTTCPTCGGEAERDTDTMDTFVDSSWYQVRYLSPHETNAPFTKAIADKWLPVDQYTGGREHAVMHLLYTRFWWKAMRDMGLVSANEPMTRLINQGVILGEDSNKMSKSRGNVIDPDMLVAQYGADTVRTFLMFIGPWEQGGPWNNRGIEGCVRFLDRAWRVVTDTPQRHDAVGDASTLERQTHRIIKKVGDDLQRFAFNTAIAGLMEFVNELMKVRETDVYGTTTWRKATETLTLLLAPIAPHIAEELWEFLGNSQSVHLQAWPSYDETLLIDESIELPVQINGKVRGKIQVAATADEPSIIATALADEKIAPLVAGKTIVKQIVVPNRLVNIVIK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAS2_AGRRH
Sequence: MDLLYAPSSTSAIEMSGQLRATLQQLETVAKFGRATASSISSVLFVSAGAGLAIARSLKRYTDQVGRNLRYEAYASATFVNLMRANPSMVNDPTTLVVLSSKSGMTPETVEAAAFLKDKACKSVVFTASANSKLASFGHQTFSTGITTQAFQAIHMLMLSLIGGILNERENWALLPALISSLQVLPAALFKAAEKGVQPGIAFAARFADDHPLYFIASGCAGIVPHAFGLCVLQERFGFEIHTVDGADFFHSFVETVRTAKRSHYILIIPDDASRPQMLDVKTFFDMRFKEGEISFQVIETTGFDMSGIDPQIGAIVGPMICEAFLKPWAPALAEATGKTMLDPLLHMGKFDYYNCHPA
What are the official names of this protein?
Agropine synthesis conjugase.
Protein: SYM_BEUC1
Sequence: MSHILSAVAWPYTNGPRHIGHVAGFGVPSDVFSRYMRMAGHDVLMVSGTDEHGTPILVLAEQEGVTPQELTDRYNRVIVDDLANLGLSYDLFTRTTTRNHYAVVQEMFRTVHKNGYMVEQTTMGAISPSTGRTLPDRYIEGTCPICGYDGARGDQCDNCGNQLDAVDLINPRSRINGEKPTFIETQHFFLDLPALADALGAWLRTRTHWRPNVLNFSLNLLDDLRPRAMTRDIDWGIPVPLPGWEDNPAKRLYVWFDAVIGYLSASIEWARRQELAAGGAGTPDAEAWRAWWNPTPGLDQQSYYFMGKDNITFHSQIWPAELLGYAGKGSRGGEPGIYGELNLPTEVVSSEFLTTEGKQFSTSRGVVVYVRDMLARYQPDALRYFIAVAGPESSDSDFTWSEFKRRTNDELVAGWGNLVNRTATMVHKNFGAVPEPGERLAVDEAVLATTRAGFAQVGRLLETQRQRAAVTEAMRVVGEVNKYVSETEPWKLKTDRDRLATVLHTATQAVADCNVLLAPFLPHAAQEIHSALGGTGTLAPQPRVDEVTDLDDASRSYPIITGDYVRGETLAPWESAAVVAGTPIEKPSPVFTKLDDAIVEEELERMRAGAAERA
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_YERPA
Sequence: MKSGRFIGVMSGTSLDGVDVVLAAIDERMVAQQASYTHPIPLQLKKDILGMCQGQSTTLSAVGKLDAQLGILFAEAVLALLAKEGLSAQDITAIGCHGQTVWHEPLGEPAFTMQLGDNNRIAAMTQIATVGDFRRRDMAYGGQGAPLVPAFHHALLAHATEKRMVLNIGGIANLSVLLPDSPIRGFDTGPGNMLMDAWIWRNCSLPYDKDACWALSGHVNQPLLEQMFNDPYFRLPAPKSTGREYFNAAWLDKQLARIPGVTAEDIQATLAELTAVSITEQVRLAGGCDRLLVCGGGARNPLVMARISALLSGTEVCTTDDAGIRGDDMEALAFAWLAFRTLSGKPGNLPSVTGASRETILGAVHPVSSW
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: OBG_BRADU
Sequence: MKFLDEAKVYIRSGDGGNGCVAFRREKFIEFGGPSGGNGGRGGNVIIEVADGLNTLIDYRYQQHFKAQKGENGAGSDRHGANGKNIVLKVPMGTQIFDEDRETLIHDFTNVGEKFVLAEGGNGGFGNAHFKSSTNRAPRNANPGQPGEERWIWLRLKLIADAGLVGLPNAGKSTFLSKVSAAKPKIADYPFTTLHPQLGVVNADGREFVLADIPGLIEGAHEGAGLGDRFLGHVERCRVLLHLVDATCEHAGKAYKTVRTELDAYGGLLTDKIEIVALNKIDAVEPDELKKQKDRLKRAAKKTPLLLSAATGEGVKEALRALVAVIGEAPVSAKAKSAAEAEPWSA
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLH1_HUMAN
Sequence: MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC
What is the function of this protein?
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR).  DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex.  Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2.  It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch.  DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.  MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR.  Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.  Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
What are the official names of this protein?
DNA mismatch repair protein Mlh1, MutL protein homolog 1.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Recruited to chromatin in a MCM9-dependent manner.
Protein: GTR5_SHEEP
Sequence: MEPQDPVKREGRLTPVIVLATLIAAFGSSFQYGYNVATINSPSEFMKDFYNYTYYDRVGEYMNEFYLTLLWSVTVSMFPFGGFLGSLMVGPLVNNLGRKGTLLFNNIFSIVPALLMGFSDLAKSFEMIIVARVLVGICAGLSSNVVPMYLGELAPKNWRGALGVVPQLFITIGILVAQIFGLRSLLANEEGWPILLGLTGIPAVLQLLFLPFFPESPRYLLIQKKDEEAAKRALRRLRGWHDVDAEIEEILEEDRAEKAAGFISVLKLFKMRSLRWQVISIIVLMAGQQLSGVNAIYYYADQIYLSAGVKEDDVQYVTAGTGAVNVLITVCAIFVVELMGRRFLLLLGFSVCFTACCVLTGALAMQDVISWMPYVSIACVISYVIGHALGPSPIPALLVTEIFLQSSRPAAYMVAGTVHWLSNFTVGLVFPFIQVGLGAYSFVIFAVICFLTTVYIFLIIPETKSKTFIEINQIFIKMNKVPGVHPEKEELKEFPPSTARQ
What is the function of this protein?
Functions as a fructose transporter that has only low activity with other monosaccharides.  Can mediate the uptake of deoxyglucose, but with low efficiency.  Essential for fructose uptake in the small intestine.  Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose.  Required for the development of high blood pressure in response to high dietary fructose intake.
What are the official names of this protein?
Solute carrier family 2, facilitated glucose transporter member 5, Fructose transporter, Glucose transporter type 5, small intestine, GLUT-5.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.
Protein: LEU3_ZYMMO
Sequence: MRIALLAGDGIGPEITAEAVKILKAVVGQEIEFDEALIGGAAWKVTGSPLPEETLKLCKNSDAILFGSVGDPECDHLERALRPEQAILGLRKELDLFANLRPARLFPELQAESPLKENIVTGTDLMIVRELTGDVYFGTPRGQRKDDQNRREGFDTMRYNEDEVKRIARIGFETARSRSGNLCSIDKSNVLETSQLWRTVVLEIAQEYPDVELSHMYVDNAAMQLVRAPDQFDVIVTGNLFGDILSDLASACVGSIGLLPSASLNSEGKGLYEPIHGSAPDIAGLGKANPLATILSGAMMLRYSLKREADADRIEKAVSTALEKGARTADLGGKMTTSEMGNAVLAALN
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_NEIMA
Sequence: MTQDKILILDFGSQVTQLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVYESDYQADTGIFDLGIPILGICYGMQFMAHHLGGEVQPGNQREFGYAQVKTIDSELTRGIQDDTPNTLDVWMSHGDKVSKLPTGFTVIGDTPSCPIAMMENAEKQFYGIQFHPEVTHTKQGRALLNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVMDMFARNLGVKVIHVDAEGQFMAKLAGVTDPEKKRKIIGAEFIEVFDAEEKKLTNAKWLAQGTIYPDVIESAGAKTKKAHAIKSHHNVGGLPENMKLKLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGVRILGEVKKEYADLLRQADDIFIQELRNTTDENGTSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAHWAELPYSLLGRVSNRIINEVKGINRVVYDVSGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: GLPE_ECOLU
Sequence: MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAVQAFHLTNDTLGAFMRDNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_LEGPL
Sequence: MTRQFLEFEQPIEELNQKIEALRMVGSDNEVNLSEEIARLEAKCSELTENIFSRLEPWQIAQMARHPLRPQTTDYIERIFTDFQELHGDRSYSSAPAIIGGMARLNGEPVMVLGHQKGKRTKEKVYRNFGMARPEEYRKALRLMRMAEKFKMPVVTFIDTAGAYPGIGAEERNQSEAIARNLFAMSRIKTPIVCIVTGEAGSGGALAIGVGDKIIMLQFSIYSVISPEGCASILWKDASKASEAARAMGITADRIFENELVDMVVPEPLGGAHRDVDEMASRLKRLLTSELQALKKVPLDQLIELRYQKFMAMGACD
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_GEOKA
Sequence: MSRQTTIPLRERNIILIGFMGAGKTTIGQLVAKKLYRDFIDVDAEIERRQGMSIPELFAQKGEAYFRKVERELIVDLCTNTRLKILSLGGGAYLQEDVRRACLAHGIVFFLDLSWEHWKEERLPLIVDSRPVLKNKTLEEVEQLFFQRQSAYALHHSRVVLNELEAEQAAEQIVESIKWTWDVYEPNR
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMIE_NOCFA
Sequence: MRHGDISSSPDTVGVAVVNYKMPRLHTKAEVLDNCRRIADMLVGMKSGLPGMDLVVFPEYSTQGIMYDEQEMYDTAATVPGEETAIFSAACREAGVWGVFSITGEQHEDHPRKPPYNTLVLIDDHGEIVQKYRKILPWCPIEGWYPGDTTYVTEGPKGLKISLIVCDDGNYPEIWRDCAMKGAELIVRCQGYMYPSKDQQVLMAKAMAWANNCYVAVANAAGFDGVYSYFGHSALIGFDGRTLGETGEEEYGIQYAQLSISAIRDARAHDQSQNHLFKLLHRGYSGVHAAGDGDRGVADCPFEFYKLWVTDAQQARERVEAITRDTVGVADCRVGSLPVEQTLEA
What is the function of this protein?
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.
What are the official names of this protein?
Aliphatic amidase, Acylamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: DLTA_STAAW
Sequence: MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVNRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIAEVING
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4NI_SINFN
Sequence: MIVATLTPLWPLLDAEERPAVVSEVARSVTRSIALAPFHIRFAVESVSIVIGLCTVLISAGAGGPLARTLRTDRFYRLLQRMPGPAGSVIRLYRSMTLLAFYDEAPVAEKLLAARPAQTS
What are the official names of this protein?
Uncharacterized protein y4nI.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TRAF3_MOUSE
Sequence: MESSKKMDAAGTLQPNPPLKLQPDRGAGSVLVPEQGGYKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESIIKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP
What is the function of this protein?
Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:17015635).  In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:19898473, PubMed:23871208, PubMed:26305951, PubMed:23150880).  Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines (PubMed:16306937).  Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance.  Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development (PubMed:17723217).  Required for normal antibody isotype switching from IgM to IgG (PubMed:19228877).  Plays a role T-cell dependent immune responses (PubMed:8934568).  Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B.  Promotes ubiquitination and proteasomal degradation of MAP3K14.
What are the official names of this protein?
TNF receptor-associated factor 3, CD40 receptor-associated factor 1, CRAF1, CD40-binding protein, CD40BP, RING-type E3 ubiquitin transferase TRAF3.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family. A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Endosome. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (PubMed:19898473). Co-localized to mitochondria with TRIM35 (By similarity).
Protein: ACTP_SALTI
Sequence: MKRVLTALAAALPFAAHAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFTEAMAVHPKGTAIMSPGGLVQDPISALSLGLGLIFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPAYKDAAGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFRKGATEREELKVSKITVLVLDVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMLGGWLGLLTAVVLMILGPTIWVQILGHEKAIFPYEYPALFSISVAFLGIWFFSATDNSAEGNREREQFRAQFIRSQTGFGVQQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UVRC_CAMJE
Sequence: MTKENLENELKTLPNSTGVYQYFNQEGKLLYVGKAKNLKNRVRSYFAFTPNLHANPRNSLRIQKMIEETVHLEFIATNSEADALILENSFIKQLHPKYNILLRDDKTYPYIYVDFEEEFPRFEITRKLVKKSKIKYFGPFFKGARELLDALYLYYPLKQKASCKSPCIFYQISRCLAPCDKLISREKYLEILDEAIHALLNPSVLLKNLEKQMLVLAQNENYEEAAKVRDQIAMIKDLEVKVEIDIAKLEDFEVFALAFKNSVLSTLRFVVQNGKIISANSKITPIKNDIQWDQNEIYKQLILENFSMDIPLLANVIYVYEEFEDRVLLEEILSQRFDKKISIKIPKIGEKRRICDLAFQNALLNIEKEQKNHDFTIQKELKSYFELENLPNDIEIFDNSHLQGVANVGAMVTYRINSWDKSKYRKFHLKHKNDYDQMREVLTRRALDFDKIPPPDLWLIDGGKALLDLAKEIIVSSGVNVDILAISKEKIDAKAHRAKGGAKDKIHSLKGEFSLSINDKKLQFLQKLRDEAHRFAISFHQNTKKKQDLKSSKLANLGLSSGVMQKLLAYYGNFESIYKADFKDLTMLVGRKAAQKIKEN
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.