PharMolix/UniProtQA huggingface dataset:
Protein: ATPG_PSYWF
Sequence: MASLKEIRAKVTSIKSTQKITRAMQMVAASKMRRAQERMEVGRPYAESMRRVVSHLVNASSDYKHPYMTNRSVNRVGYILVTSDRGLAGGLNINLFKKLMHHVQEFQNQSVEAEFAVIGSKGVSFFKSFGGKVTSAVTDYGDNPTFEQLNAPVQAMLDDYANGRLDRIYMVYNKFVNAMTQQPIVTQLVPLPDSAIDSADAGINTELSWDYIYEPDVKTLIDGLLNRYIESIVYQAVMENIASEQSARMVAMKAATDNAGDLINDLQLVYNKLRQAAITREISEIVGGAAAVS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MIAB_MICAN
Sequence: MNKSPRRYHITTFGCQMNKADSERMAGILEDLGFQWSEDANEADLILYNTCTIRDNAEQKVYSYLGRQAKRKQTQPDLTLIVAGCVAQQEGEQLLRRVPEVDLIIGPQHANRLGDLLQQVFDGSQVVATEPIHIMEDITKPRRDSNITAWVNVIYGCNERCTYCVVPGVRGVEQSRTPAAIRAEMAQLGQQGYQEITLLGQNIDAYGRDLPGVTASGRHLHNFTDLLYYVHDVAGIERLRFATSHPRYFTERLIKACQELPKVCEHFHIPFQSGDNDILKAMKRGYTQEKYRQIIANIRDLMPDAAISADAIVGFPGETEAQFENTLKLVDEIGFDQLNTAAYSPRPGTPAAIWDDQLSEQVKSDRLQRLNHLVATKAAERSQRYLGRIEEILVEDVNPKDASQVMGRTRGNRLTFFTGDIEELRGKFVKVKITEVRPFSLTGVIF
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C1QBP_RAT
Sequence: MLPLLRCVPRALGAAATGLRASIPAPPLRHLLQPAPRPCLRPFGLLSVRAGSARRSGLLQPPVPCACGCGALHTEGDKAFVEFLTDEIKEEKKIQKHKSLPKMSGDWELEVNGTEAKLLRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKAEEQEPELTSTPNFVVEVTKTDGKKTLVLDCHYPEDEIGHEDEAESDIFSIKEVSFQTTGDSEWRDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFVKSQ
What is the function of this protein?
Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing.  At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades.  Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93.  In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK.  Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation.  May function to bind initially fluid kininogen-1 to the cell membrane.  The secreted form may enhance both extrinsic and intrinsic coagulation pathways.  It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response.  By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading.  Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway.  Required for protein synthesis in mitochondria.  In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity.  May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles.  Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation.  Is required for the nuclear translocation of splicing factor U2AF1L4.  Involved in regulation of CDKN2A- and HRK-mediated apoptosis.  May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription.  May play a role in antibacterial defense.
What are the official names of this protein?
Complement component 1 Q subcomponent-binding protein, mitochondrial, GC1q-R protein, Glycoprotein gC1qBP, C1qBP.
What is the protein family that this protein belongs to?
Belongs to the MAM33 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes.
Protein: RL35_SYNS9
Sequence: MPKLKTRKAAAKRFKATGTGKFLRRRAFRNHLLDHKTPKQKRHLGTKAVVDRTDVERVTLMMPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: TPS3_PHYPO
Sequence: MEVLRQMLVHKANNSSMSTHKGLNRTEPVRMTYDHCELLGQLSTLNFSAASNTFSSGYNTTIKGSAPKTIQTVSSLFSKDITKAMSDIGNLVARMFPTASAERAAVILDITVFGFIADDLLEDAALSSDSEAFDKLHMLMLRLVRNDSFSEDEYPEYQNLIRFTRPIFTKFQALASRTLLNRFAYTYQEYLQGVQWEASLQPNQIPDFETCKNVKRHVGAWLCYFVLAEFAREIEVPITVRGNLEVQKFVTLACDIASYDNDTFLLKKEIRDGVVSNTIVITYLHGAKRLQDALDRILEMRKQTESEILAITSNLPHFGKDDKVAREYINALTCVIGGNFEWCSKTTRYQDPK
What is the function of this protein?
Terpene synthase that may be involved in the production of volatile terpenoids (PubMed:31839833).  Does not show detectable terpene products with either farnesyl diphosphate (FPP) or geranyl diphosphate (GPP) (PubMed:31839833).  P. polycephalum has a unique biology and these volatile terpenoids could function in internal communication of P. polycephalum, to mark the territory that have been explored, or they may be involved in chemotaxis (Probable).
What are the official names of this protein?
Terpene synthase 3, TPS3, Terpene cyclase TPS3.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: MEND_SALTY
Sequence: MSVSAFNRRWAAVILEALTRHGVRHVCIAPGSRSTPLTLAAAENPAFIHHTHFDERGLGHLALGLAKVSQQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQAGMFASHPSQTLSLPRPTQDIPARWLVSTIDNALAMLHAGALHINCPFAEPLYGDMNDTGLVWQQRLGDWWQDEKPWLREARRLESDKQRDWFFWRQKRGVVVAGRMSAEEGKKVAQWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKAVTELQQAQIVVQLGSSLTGKRLLQWQATCEPEEYWVIDNIEGRLDPAHHRGRRLVAKIADWLELHPAEKRKPWCVEIPRLAELAWQRVVAQRDTFGEAQLAHRIRDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASAKSTLAIVGDLSALYDLNALALLRQVSAPFVLIVVNNNGGQIFSLLPTPQSKRERFYLMPQNVHFDHAAAMFNLRYHRPENWEELESALAGAWRTPATTVIELVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: HEY1_MOUSE
Sequence: MKRAHPDYSSSDSELDETIEVEKESADENGNLSSALCSMSPTTSSQVLARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLLVRLVSHLNNYASQREAASGAHGGLGHIPWGSAFGHHPHIAHPLLLPQNGHGNAGTAASPTEPHHQGRLASAHPEAPALRAPPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFSSFHLLSPSTPTQAANLGKPYRPWGTEIGAF
What is the function of this protein?
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'.  Downstream effector of Notch signaling required for cardiovascular development.  Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development.  May be required in conjunction with HEY2 to specify arterial cell fate or identity.  Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification.  Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.
What are the official names of this protein?
Hairy/enhancer-of-split related with YRPW motif protein 1, Hairy and enhancer of split-related protein 1, HESR-1, Hairy-related transcription factor 1, HRT-1, mHRT1.
What is the protein family that this protein belongs to?
Belongs to the HEY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRFM_MOUSE
Sequence: MRLLSVTFWLLLSLRTVVCVMEVQWCTISDAEQQKCKDMSEAFQGAGIRPSLLCVQGNSADHCVQLIKEQKADAITLDGGAIYEAGKEHGLKPVVGEVYDQDIGTSYYAVAVVRRNSNVTINTLKGVKSCHTGINRTVGWNVPVGYLVESGHLSVMGCDVLKAVGDYFGGSCVPGTGETSHSESLCRLCRGDSSGHNVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGNTLPSWGKSLMSEDFQLLCRDGSRADITEWRRCHLAKVPAHAVVVRGDMDGGLIFQLLNEGQLLFSHEDSSFQMFSSKAYSQKNLLFKDSTLELVPIATQNYEAWLGQEYLQAMKGLLCDPNRLPHYLRWCVLSAPEIQKCGDMAVAFSRQNLKPEIQCVSAESPEHCMEQIQAGHTDAVTLRGEDIYRAGKVYGLVPAAGELYAEEDRSNSYFVVAVARRDSSYSFTLDELRGKRSCHPYLGSPAGWEVPIGSLIQRGFIRPKDCDVLTAVSQFFNASCVPVNNPKNYPSALCALCVGDEKGRNKCVGSSQERYYGYSGAFRCLVEHAGDVAFVKHTTVFENTNGHNPEPWASHLRWQDYELLCPNGARAEVDQFQACNLAQMPSHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFQMFDSSKYHSQDLLFKDATVRAVPVREKTTYLDWLGPDYVVALEGMLSQQCSGAGAAVQRVPLLALLLLTLAAGLLPRVL
What is the function of this protein?
Involved in iron cellular uptake.  Seems to be internalized and then recycled back to the cell membrane.  Binds a single atom of iron per subunit.  Could also bind zinc.
What are the official names of this protein?
Melanotransferrin, Membrane-bound transferrin-like protein p97, MTf.
What is the protein family that this protein belongs to?
Belongs to the transferrin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: RS8_AGRFC
Sequence: MTMTDPLGDMLTRIRNGAARRKSSVSTPASSLRARVLDVLQSEGYIRGYSKVDFENGKAEFTIELKYYEGASVIREIGRVSKPGRRVYVSVKSIPQVANGLGITILSTPKGVMADHQAREQNVGGEVLCSVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NRMP2_POPTR
Sequence: MSSPSGGEDSKDDEKDEESNRLLPLSSSSQSQSLQSENYSDEVAFEAREKIVIVDVEGPHSIDAVDYVPPFSWRKLWLFTGPGFLMSIAFLDPGNLEGDLQAGAIAGYSLLWLLLWATVMGLLIQMLSARVGVATGRHLAELCRDEYSNWARYILWFMAEVALIGADIQEVIGSAIAIQILSNGFLPLWAGVLITASDCFMFLFLENYGVRKLEGVFAVLIATMALSFAWMCGDAKPSGKELLKGILIPRLGSKTIRQAVGVVGCVIMPHNVFLHSALVQSRKIDPQKKARVQEALTYYSIESSVALFVSFMINLFVTTVFAKGFYGTPQASSIGLVNAGQYLEEKYGGGLFPILYIWGIGLLAAGQSSTITGTYAGQFIMGGFLNLRLKKWTRALITRSFAIIPTIIVAIIFNTSEASLDILNEWLNVLQSMQIPFALIPLLTLVAKEQVMGVFKIGPVLERLAWTIAVLVILINGYLLIDFFISEVKGLLFGFLIGSGTVAYVSFIIYLVSRCGTSPSNGLSLELSERITCNGN
What is the function of this protein?
Probable divalent metal transporter.
What are the official names of this protein?
Metal transporter Nramp2, PotriNRAMP2, PtNRAMP2, Natural resistance-associated macrophage protein 2.
What is the protein family that this protein belongs to?
Belongs to the NRAMP (TC 2.A.55) family.
Protein: GATA3_DANRE
Sequence: MEVSPEQHRWVTHHTVGQHPETHHPGLGHSYMDPSQYQLAEDVDVLFNIDGQSNHPYYGNPVRAVQRYPPPPHSSQMCRPSLLHGSLPWLDGGKSIGPHHSTSPWNLGPFPKTSLHHSSPGPLSVYPPASSSSLSAGHSSPHLFTFPPTPPKDVSPDPAISTSGSGSSVRQEDKECIKYQVSLAESMKLDSAHSRSMASIGAGASSAHHPIATYPSYVPDYGPGLFPPSSLIGGSSSSYGSKTRPKTRSSSEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKSKKSHDSMEDFSKSLMEKNSSFSPAALSRHMTSFPPFSHSGHMLTTPTPMHPSSSLPFASHHPSSMVTAMG
What are the official names of this protein?
Transcription factor GATA-3, GATA-binding factor 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: COX2_MYXGL
Sequence: MANHLQFNFQDATSPLMQELVKFHDHSLTILFFISALILYVLMMTSLSKLTNKNILDSQEIEMVWTVIPAFILIMLALPSIQILYLMDEIASPDITIKTVGHQWYWTYEFSDLSKESEIESYMLPTADLQNGDFRLLEVDNRISVPMDSKIRMLITSEDVLHAWTLPSMGIKVDAVPGRLNQVTFSSSLPGLFFGQCSEICGANHSFMPIAMEVIPLKTFESWIIKLSL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LEF11_NPVEP
Sequence: MNNCATFSMPHSNATNHTTLSHPVCNNNANCFTRSELYAIWSETINTLKRTFKIKNVHAHMLEDDSGEIKDYIRANLSRFTVITGKCSKRKVCHHDKRIARTLHLEKNLVDEYACSVTHVYSAPKW
What is the function of this protein?
Involved in late/very late gene activation.
What are the official names of this protein?
Late expression factor 11.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae LEF-11 family.
Protein: TSAD_AQUAE
Sequence: MRTLAVETSCDETALAIYDDQKGVLGNVILSQAVVHSPFGGVVPELSAREHTRNILPIFDRLLKESRINLEEIDFISFTLTPGLILSLVVGVAFAKALAYEYRKPLVPVHHLEGHIYSVFLEKKVEYPFLALIISGGHTDLYLVRDFGRYDFLGGTLDDAVGEAYDKVAKMLGLGYPGGPIIDRLAKEGKKLYPLPKPLMEEGNLNFSFSGLKTAILNLLKKEKNVRKEDIAYSFQETVVEILLEKSLWAMKKTGIKRLVVVGGVSANSRLREVFKKASQEYGFELYIPHPSLSTDNALMIAYAGMERFKRGVVAPLDVNPQPNIPLEEFGRIWT
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_HELHP
Sequence: MISIIIDSLRESALHIDSLLKDTSTSYLQSINASGDMQLEIDVRVDKFLSEKLLNLPCVKAICSEEQEEIMYSENKNAPYIIAYDPLDGSSLIDSNLSIGTIFGIYNEELSAKHLIASGYIIYGPRLEMVVAQEQALHYRYNGNMWRNLGALALNTKGKINAPGGTQKHWENKHKAMIESLFAQGYRLRYSGGMVPDLHQILIKGGGLFSYPATSDAPNGKLRKLFEVFPFAFVYEKAGGFATNGTYRILELEVAHLHDSTPCFFGSQSEMNLVKEVYE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX27_BOVIN
Sequence: MADEDGEGIHPAAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNGVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVAT
What is the function of this protein?
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.  Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes.  SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling.  SNX27 also binds with the WASH complex.  Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)).  May participate in establishment of natural killer cell polarity.  Recruits CYTIP to early endosomes (By similarity).
What are the official names of this protein?
Sorting nexin-27.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3- kinase products (By similarity).
Protein: HIS3_LISMC
Sequence: MTSVDFSKGLVPTIILDDQNGDVLMLAYMNEESYQKTLETGYTWFFSRSRNELWNKGATSGHTQKVKQIWTDCDNDTLLIRVTQIGPACHTGKKSCFFNLIKEDF
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXB_KLEP7
Sequence: MAEQRPLTIALVAGETSGDILGAGLIRALKARIPNARFVGVAGPLMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTRRFGELRPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTDLVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKGAARDRLGIPHSVRCLALLPGSRGAEVEMLSADFLKTAQLLRATYPDLQVVVPLVNAKRREQFERIKAETAPDMIVHMLDGQARDAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQDECEPQALAAALQPLLADGKTSHEMHETFRALHQQIRCNADEQAADAVLELAKQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: TADBP_HUMAN
Sequence: MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
What is the function of this protein?
RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609).  Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995).  In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978).  Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432).  Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513).  In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:23398327, PubMed:19765185).  Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263).  Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980).  Negatively regulates the expression of CDK6 (PubMed:19760257).  Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563).
What are the official names of this protein?
TAR DNA-binding protein 43, TDP-43.
Protein: AROK_BRUA2
Sequence: MSGTNKQTNLHRQTETIRQLLGSKVVVLVGLMGAGKSTIGRKVANMLNLPFKDADTEIETVSRMTVAELFEAYGEVEFRDLERRVILRLLDDGPMVLATGGGAYMNAETRAAIAEAGISIWINADLDVLMERVSRRQNRPLLRNSDPRGVMQRLMDERYPVYALAELHLMTRDEKKEVIAAELIEVLAAHLEKEQAASAG
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VMA21_KLULA
Sequence: MPVDVPRSVIAKLMFFTVAMVVLPVLTFFWLQEHTDNTLVSGGLAAAMANLVLIAYVIMAFQEDSSSSEDDETKKEK
What is the function of this protein?
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
What are the official names of this protein?
Vacuolar ATPase assembly integral membrane protein VMA21.
What is the protein family that this protein belongs to?
Belongs to the VMA21 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Protein: RPOZ_YERPP
Sequence: MARVTVQDAVEKIGNRFDLVLVAARRARQIQSGGKDALVPEENDKVTVIALREIEEGLITNQILDVRERQEQQAAEIQAVTAIAEGRR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PETM_GLOC7
Sequence: MTAESMLFNGAILSIVLVLVGLAWGFLLLKIQGGEAE
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 7, Cytochrome b6-f complex subunit PetM, Cytochrome b6-f complex subunit VII.
What is the protein family that this protein belongs to?
Belongs to the PetM family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.