PharMolix/UniProtQA huggingface dataset:
Protein: TREM2_HUMAN
Sequence: MEPLRLLILLFVTELSGAHNTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHNLWLLSFLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEADTLRKVLVEVLADPLDHRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTSILLLLACIFLIKILAASALWAAAWHGQKPGTHPPSELDCGHDPGYQLQTLPGLRDT
What is the function of this protein?
Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849).  Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356).  Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity).  Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018).  Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (PubMed:29794134).  Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity).  Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881).  Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity).  Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity).  It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity).  During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity).  Plays a role in microglial MTOR activation and metabolism (By similarity).  Regulates age-related changes in microglial numbers (PubMed:29752066).  Triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849).  Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity).  In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640).  Involved in the positive regulation of osteoclast differentiation (PubMed:12925681).
What are the official names of this protein?
Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted. SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
Protein: RRAA_YERPG
Sequence: MKYDTSDLCDIYHEEVNVVEPLFSNFGGRTSFGGKITTVKCFEDNGLLFDLLEENGLGRVLVVDGGGSVRRALINAELAELALKNEWEGIVVYGAVRQVDDLAELDIGIQAMAAIPVGAADEGVGESDIRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3ST3_MOUSE
Sequence: MPPILQRLQQSTKMMSHRKILLLVLGCSTVSLLIHQGSQLSWYPKLFPLSCPPLRESPPRAKHMAVAFLKTHKTAGTTVQNILFRFAERHNLTVALPHPSCEHQFCYPRNFSAHFVHPATRPPHMLASHLRFDRAELERLMPPDTIYVTILREPAAMFESLFSYYNQYCPAFRRVPNASLETFLRAPEAYYRPGEHFAMFAHNTLAYDLGGDNERSPRDDAAYLAGLIRQVEEVFSLVMIAEYFDESLVLLRRLLAWDLDDVLYAKLNARAASSRLATIPEALARAARTWNALDAGLYDHFNATFWRRVARAGRACVEREARELREARQRLLRRCFGDEPVLRPAAQIRTKQLQPWQPSRKVDIMGYDLPSGGAGPTTEACLKLAMPEVQYSNYLLRKQKRRGGVRSRPESVLDNPPPRPIRALPRIPQGT
What is the function of this protein?
Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans.  Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc (By similarity).
What are the official names of this protein?
Galactose-3-O-sulfotransferase 3, Gal3ST-3, Beta-galactose-3-O-sulfotransferase 3, Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3.
What is the protein family that this protein belongs to?
Belongs to the galactose-3-O-sulfotransferase family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: MT2A_ORYSJ
Sequence: MSCCGGNCGCGSGCQCGSGCGGCKMYPEMAEEVTTTQTVIMGVAPSKGHAEGLEAGAAAGAGAENGCKCGDNCTCNPCNCGK
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-like protein 2A, Class I metallothionein-like protein 2A, OsMT-I-2a, OsMT2a, OsMT2-1.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: SYN_STRP8
Sequence: MSKKLISIVDVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSAFFQGVAFKPNFIEKYGEESGLEKFDVIKRLNQETSVYVTGIVKEDERSKFGYELDITDLEIIGESHEYPITPKEHGTDFLMDNRHLWLRSRKQMAVMQIRNAIIYATYEFFDQNGFIKFDSPILSENAAEDSTELFETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFLSHEESLDLQEAYVKALIQGVLDRAPQALDILERDVEALKRYITEPFKRVSYDDAITLLQEHEADEDTDYEHLEHGDDFGSPHETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREDNYDALVAKMDELGMDKSEYDFYLDLRKYGSVPHGGFGIGIERMVTFVAGTKHIREAIPFPRMLHRIRP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEN2_DANRE
Sequence: MNLERIPNEEKLSLCRRYYLGGFAFLPFLWLVNILWFFKEAFLKPAYTEQPQIKSYVKKSALGLLLWVAVLTTWITVFQHFRAQWGEVGDYLSFTIPLGTA
What is the function of this protein?
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
What are the official names of this protein?
Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the PEN-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Protein: PURO_METTH
Sequence: MYLGRILAVGRNSNGSFVAYRVSSRSFPNRTTSIQEERVAVVPVEGHERDVFRNPYIAYNCIRIVGDTAVVSNGSHTDTIADKVALGMNLRDAIGLSLLAMDYEKDELNTPRIAAAINGSEAFIGIVTADGLMVSRVPEETPVYISTYEQTEPAATEFKAGSPEEAAEFILKGGEFAAFTHPVTAAAAFNDGEGWNLATREM
What is the function of this protein?
Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.
What are the official names of this protein?
IMP cyclohydrolase, IMP synthase, Inosinicase.
What is the protein family that this protein belongs to?
Belongs to the archaeal IMP cyclohydrolase family.
Protein: YJ09_YEAST
Sequence: MPAGRIRIAMTDNIIVSEVDGPPDVVKCFIREEDGLEGQSRELVVIGLEYIDVFEGVEQDEARKKLRLRTVGYTMAAFYFKDHTAPNRRFYILLKATGRLDFVNLDYKIVKSLETGIDQVRSEPKFMFQDPLRTALVFNLSCTEIYEISTEDIFCLEETDVKLSYVTSSPIVSIDACINFNDFLDKDVFTLSILTRAHNEVAYKLEACVCVFESKPAKGTKWQRTTNLTFVEEATVSQVLLKSVTNIGHFVFTPWKTYFIKHALSSKQTIDGKTVDKIYQGPGAFGSDNMERIELLQPILADTTLNHLTFTFMTSTAILITCRMNAILSSFEDDTYIWEKALFERLPINGGSSHDHYLAAFFNEKCWILVSPKGHLTVYSVRNEGHSNFVHLGSFLCKSTLYSDLIGNYTKSHLSCGSLHCGQGYLCLKFRSCGDIFASTCMKLLFKSKDSVPRQVYSTRKGIYWADVNNNVYRDSERIDFEINGSFIATKDGTLLKDNTIVTLVPIQRDNECNYAYVTKQGYLRWSFSKVYYRIQNTGVDLTIDNCFLSAISSKGSFLTVLVLNDEITVFDHCNRLKSQKVVFHRLSDLASIFLYEYESTVYIFMSDTEGNLCVMKLATFEIVEEVKICKKKLQFCEVPNSDYFFIYTADTIIFFKPSKIKGRFKIQEVYAPCPISCLIPGEKDGSVVMVTSQGQFYDVLVPGDAGRATLCSKFEKVLKTCLKFITLESSSRYVIVAALPVANPLQDKYSEIYVYDIKQFKNISAFNFSNLNNDIESIKYENAMISDIIAVPMLKRTETLGKRKTSELYKEVIFNSCILVSLNLDSIDGIDSKNMNNLLLFSFDEESGFIEFVFGINTGFSISGLHNYYNGCVLVYGEFVQAYQLNYSVHDNKFSIEQVSNRLNISGITITSSIFFDKRKAKMARKQQNIGTWVYLEEMILLDVRKGVMRFNVIHTTDGNIEKVQLQVQPLNLFERDLINSITDTGKMFTGAAAITFKNIRYLLISYGDQKLTLFSLKLDGEEEIDERVYHVAEQVTTINSVRTTDSRMSTFLGESTFMPLFLVSTLSNGCYVIGILHEESDISLHILSEKKAVFAKRSVQKFLGFLDPQMDDHTVISEI
What are the official names of this protein?
Uncharacterized protein YJR039W.
Protein: VMA5A_MOUSE
Sequence: MEHHCGLITSNKETVPLKNISVTLSINEFVAAVVATLNYENEEKVPLEATFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKAHSEYEEALSQGHQAYLLEEDDYSRDVFSCNVGNLQPGAKVAVTLRYVQELPLETDGALRYLLPAILNPRYQLSEQSANSCLNIQKPTVPLEDLPYTLNMTATITSQHGIERVQSNCSLSPIQYLTDDKTSAQVSLTEGHKFDRDVELLIYYNEVHSPSVAVEMGMLDMKPDSLMGAPSAMVSFYPDIPEVEASKACGEFVFLMDRSGSMDSPMSTENNSQLRIEAAKETLLLLLKSLPMGCYFNIYGFGSSYEKFFPESVKYTQDTMEDAVKRVKALKANLGGTEILTPLCNIYKASSIPGHPLQLFVFTDGEVSDTFSVIREVKLNSKKHRCFSFGIGQGASTSLIKNIARVSGGTAVFITGKDRMQTKALGSLKFALQCAVDNISLSWDLPPGLSVKMLSPEQLTIFRGQRLIIYAQLTGLMPQVESTGAVCLKHILQGRSLENRVTFSLQPKANDNFTIHRLAAKSLIQTKDFGSQEASKEEKEDVMNISLQSGVLSSFTAFIAINKELNKPVQGPLAHRVIPRPVMAGSSSMRFYSSFSGGFKGPQPRSLRVPAYDLCSAESANLVLKKSACSAIQKKKTNSSTNKSNLKKEHKAFGENAVVQLISLQKANGSWELDEDLTKILGTKSKDIKAANPAKHEDPSAWSTVLAVVWLHANGTDLKCEWELLERKAVAWLHDHAGSSIPMLVQAANSLLKLSVNPAVFGV
What is the function of this protein?
May play a role in tumorigenesis as a tumor suppressor.  Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity).
What are the official names of this protein?
von Willebrand factor A domain-containing protein 5A, Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.
Protein: ALAA_MYCBO
Sequence: MDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGPVHQHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSARRAVVTRYELVPGFPRFDVDDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTASTSLAGGTPVHYLCDETQGWQPDIADLESKITERTKALVVINPNNPTGAVYSCEILTQMVDLARKHQLLLLADEIYDKILYDDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGWLAITGPKEHASSFIEGIGLLANMRLCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQRDIAWTKLNEIPGVSCVKPAGALYAFPRLDPEVYDIDDDEQLVLDLLLSEKILVTQGTGFNWPAPDHLRLVTLPWSRDLAAAIERLGNFLVSYRQ
What are the official names of this protein?
Alanine aminotransferase, Alanine transaminase, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_STAEQ
Sequence: MVKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: MPH1_BOTFB
Sequence: MSDDEYGDIDEDVWDVAEALTQASQTLPSNSPHRRKRRRISSDQELDDYNDDGLSIQQRRRSRGSASSDHDEGDEKRQSKYRIHLGAEEVPAAVIMGATQADGMPDSSPYRIRGPIYKRPRPLPSPELEPKSTQALASVFRPTKAQKQNIVPQPAPAAAYDFSKELEDLPSDAFSPSPPQQGMSTGLITINSSPPFESTQSIISQRLVAPQNGLRQTTLFGGRAPNQAPSSTQAKKVHNYLVDKVPEPPTHHSLDREAIKTWVYPNNLGPERRYQYTIVHKGLFNNLLVALPTGLGKTFIAATIMLNFFRWTKNSQIVFMAPTKPLVSQQVKACFEIAGIPRSSTTMLTGDQTPALRAEEWDEKRVFFMTPQTVENDLKTGIADPKRIALLVVDEAHRATGKYAYTKVVEFLRRFNKSFRVLALTATPGSTVEAVQEVIDNLEIAEVEIRTEESIDIKEYVHRRDITEILIDPSDEIIMVRDLFSKALQPLVNLLCSQKAYYNKDPMSLTQFGMLTARKTWMASGAGKSANMGVKGMMNALFTVLTSMGHAIKILNFHGIGPFFSNIKDFRAEVEGNKKGGKYKNQVVNDPDFKKMMDRIQSWINKEEFIGHPKLTHLCDTVLNHFLDAGAGLTGDNMPPSSTRVIVFTEYRDSAEDIARVLNKHGPMIKASVFVGQSDSKRSEGMNQEKQLETIRKFKAGGINVIVATSIGEEGLDIGEVDLIVCYDSSSSPIRMLQRMGRTGRKRAGKIVLLLMRGKEEDSYKKSKDNYEQMQRMISSGSRFTFRHDLSARIIPRDVKPEVEKRFIEIPPENTQDPSLPEPKRRAKARKKPAKKFHMPDGVETGFRNASKLNGNVAGPPSRIFGIKRKPNELNDDELAPIPLLDSVLLSGRDMAELDRRFLRVPDGALEEVEMPDLTAQTITQRSLTMTAKVSHGKYTRKCVDLFSKLSRSQASEDRDIKPYGDEAPSDLGKMPTMPLEAELARIPKAPKPTQVSKLPQVTKTTSAPKKTPASRKAIPKKAPTRRNRPLQHENSDSEDSTASMAMVSNLRSSQIPQPTPDSEEEGPGERVDRTSDMEDLEASDDSDLGSLVDFIDPTQIQTQMTLTGTSSFSSSPPQMERWDGDERQKRRGRGGLLGRAVERDKAKNLSSQRSIPTMTQESSDDDLPTIEDLVRGDTTTKKTVDFPSSSVLSSGKKATPNMFTRKRDGDVRGRGAKRRIVDSDDSDE
What is the function of this protein?
ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance.  Capable of unwinding D-loops.  Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair.  Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
What are the official names of this protein?
ATP-dependent DNA helicase MPH1, FANCM-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMH_MESHJ
Sequence: MHVPVLLEELILALEINPKGFYVDLTLGRGGHSLAILEKISNGKLVVFDKDQDALDQTRPKLLAYKQNIEIIWSDFSRFDFYLENLGIQFVDGFIIDLGVSSPQIDDPERGFSYSKDGNLDMRMDKSQKLSAFIVLNEYPYEKLVEIFFKYGQIPYAREIARAIINSRPLKTTFELVNLVKKVIPALVLVKKNFIKNVFQAVRIEVNNELDSLQKLLEKLPKFLKQGSKVAIITFHSLEDRIVKKAFLDLIRKDKLEFFQKGLPKFSMKVFRPKANELKSNPRAKSAKLRLLLKNR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHGB_ASPFC
Sequence: MRLHAFTLLSLLGLVPSFAAASLSGSVGPLTSASAKAAKKTCNVLDYGAKADKKTDLGPPLAAAFAACKSGGLVYIPAGDYAMSTWVKLANGKAWALQIDGVIYRTGTDGGNMIMIEHTSDFELYSSTSSGAMQGLGYEFHASNNWSGPRLLRLWDVSDFSVHDLILVDSPSFHFSIDTCSNGEVYNMAIRGGNHGGLDGVDVWSTNIWIHDLEVTNKDECVTVKSPAKNILVENIYCNLSGGCAMGSLGADTDISDITYKNIYTWNSNQMMMIKSNGGSGTVSNVVFENFIGHGNAYSLDIDSFWSSMSAVSGDGVTLNNITIKNWKGTEANGAQRGPIKIICPDKVPCYNILIEDFAMWTETGSKQWYSCQSAYGSGFCLKSGSHHTSYAVTTTTVSSAPSGYSAAKMASDLSTDFGSTKSIPIPTIPTSFYPGATPYSALMSKQSTKAAKARAVDMSVETPAAASRSEQVVQGAPQETGQSAPESAGPVPSGNPGPVPTGGSRPSRHRHGHHHFGSAI
What is the function of this protein?
Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins (By similarity).
What are the official names of this protein?
Probable rhamnogalacturonase B, RGase B, RHG B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YJBM_BACSU
Sequence: MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVTGRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVVDQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ
What is the function of this protein?
Functions as a (p)ppGpp synthase; GDP can be used instead of GTP, resulting in an increase of (p)ppGpp synthesis (PubMed:18067544).  The enzyme binds ATP, then GDP or GTP and catalysis is highly cooperative (PubMed:26460002).  In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  Probably has a minor role in the stringent response (PubMed:18067544).
What are the official names of this protein?
GTP pyrophosphokinase YjbM, (p)ppGpp synthase YjbM, Small alarmone synthase 1, SAS 1.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: G6PI_STRR6
Sequence: MSHIKFDYSKVLDKFVAPHEVEYMQSQVTAADELIRKGTGAGSDFLGWLDLPEKYDREEFDRILKAAEQIKSDSDVLVVIGIGGSYLGAKAAIDFLNHHFANLQTKEERKAPQILYAGNSISSTYLADLVEYVADKDFSVNVISKSGTTTEPAIAFRVFKELLVKKYGQEEANKRIYATTDRQKGAVKVEADANGWGTFVVPDDIGGRFSVLTAVGLLPIAASGADIKALMEGANAARKDYTSDKISENEAYQYAAVRNILYRKGYATEILVNYEPSLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGTRIMFETVVRVDKPRKNVLIPTLEEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGDVPNMYVTLPEQDAFTLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKRNMFALLGKPGFEELSKELNARL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCX5_ANDMA
Sequence: LKDGYIIDDLNCTFFCGRNAYCDDECKKKGGESGYCQWASPYGNACWCYKLPDRVSIKEKGRCN
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Alpha-toxin Amm5, Amm V, AmmV, Neurotoxin 5, Neurotoxin V.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TXD12_HUMAN
Sequence: METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
What is the function of this protein?
Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.
What are the official names of this protein?
Thioredoxin domain-containing protein 12, Endoplasmic reticulum resident protein 18, ER protein 18, ERp18, Endoplasmic reticulum resident protein 19, ER protein 19, ERp19, Thioredoxin-like protein p19, hTLP19.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: 3NO27_NAJNA
Sequence: LTCLNCPEVYCRRFQICRDGEKICFKKFDQRNLLGKRYRRGCAATCPEAKPREIVQCCSTDKCNR
What is the function of this protein?
Binds with low affinity to muscular (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).
What are the official names of this protein?
Weak neurotoxin 7.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily. Orphan group II sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NT101_ARATH
Sequence: MRKKVDERIRTLIENGVKLRHRSMFVIIGDKARDQIVNLHHILSKSVVKSNPSVLWCYKNRLDISSHNKKRAKQLKKMKERGQLDPEKLDAFSLFLDVVDVTHCLYKDSERILGNTFGICILQDFEALTPNLLARTIETVEGGGLVVLLLQSLASLTSLCTMVMDVHDRFRTESHSEASGRFNERFLLSLASCKACVVMDDELNLLPLSSHIKSITKVPTKEDSEALSEAERDLKSLKDALNDDFPVGPLINKCCTLDQGKAVVTFFDAILDKTLRSIVALIASRGRGKSAALGLAVAGAVAAGYSNIYVTAPSPDNLKTVFEFVCKGFDALEYKEHLEYDVVRSVNPEFNKAIVRINIFKQHRQTIQYIQPHEHEKLSQVELLVIDEAAAIPLPVVKSLLGPYLVFLSSTVSGYEGTGRSLSLKLLQQLEEQSRAPVTGVEGSLSGCLFKKIELSESIRYASGDPIESWLNGLLCLDVANCLPNPACHPLPSQCDLYYVNRDTLFSYHKDSELFLQRMMALCVSSHYKNSPNDLQLLSDAPAHHLFVLLGPVDESKNQLPDILCVIQVCLEGQISRKSAEKSLREGHSPHGDQIPWKFCEQFRDVVFPKLSGARIVRIAVHPNAMKMGYGSAAVELLTRYFEGQLASISEGDDELEVEPSPVRVTEAAAKVSLLEEQIKPRANLPPLLVPLRDRRPERLHYIGVSFGLTLDLFRFWRKHKFAPFYISQIPSAVTGEHTCMLLKPLTLSNDEFEVDESDELGFFAPFYKDFRIRFSKLLSDKFKKMDYKLAMSVLNPKINFPEVDLTGNSPDGFLKKLDGVLSPYDMERFRAYTANLVDFNLVYDICKTLAHHYFQEKLPVSLSYVQASVLLCLGLQESDFSSIERQMQLERGQIYSLLLKVGKKLYKYLNGIATKELESTLPRLKDRVLEPHKVSVDEDLREGAKEVEEQMRARIEELLDPELLDQFAIGDKEAEALQKSKISSSGLISIESTKTDNKKEKPSGFDKSAKKRGNDKHSSTSNKKRRA
What is the function of this protein?
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs.  Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA.  Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis.  Catalyzes the formation of ac4C in serine and leucine tRNAs.  Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
What are the official names of this protein?
RNA cytidine acetyltransferase 1, 18S rRNA cytosine acetyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PPR42_DANRE
Sequence: MVRLTVHLIAKLGSHSKSSRSESFQQYLRKLTHLNFSDKNIEEIDDLSVCRNLTVLYLYDNQISQICNLGFASNLTHLYMQNNNISCIENLSSLHKLSKLFLGGNSITVVEGLEELKSLKELHVEGQKLPCGEKLAFDPHSISSLSETLCILNISKNNIDELWDLAPLRKMTHLFAADNQLHDIQELETVFSQWFKLRLLDLSRNPVCHKPKYRDRLITVCKFLDDLDGKQINELSRQFLINWKASKDAKKKPEDGKDNKLQVANQLSTSADFHLGPQHPSVRERSSSLSKPSENEKPGVTFRTDQIQADSRGRGTRGDSSTEWQSLKI
What is the function of this protein?
May regulate phosphatase activity of protein phosphatase 1 (PP1) complexes.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 42, Leucine-rich repeat-containing protein 67.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: CATR_SCHDU
Sequence: MSYRKAASARRDKAKTRSAGLTEEQKQEIREAFDLFDTDGSGTIDAKELKVAMRALGFEPKKEEIKKMIADIDKDGSGTIDFEEFLQMMTAKMGERDSREEIMKAFRLFDDDETGKISFKNLKRVAKELGENMTDEELQEMIDEADRDGDGEVNEEEFFRIMKKTSLF
What is the function of this protein?
This calcium-binding protein is found in the basal body complexes (the functional homolog of the centrosome in animal cell).  In mitotic cells it is specifically associated with the poles of the mitotic spindles at the sites of the duplicated basal body complexes.
What are the official names of this protein?
Caltractin, Centrin.
What is the protein family that this protein belongs to?
Belongs to the centrin family.
Protein: FITM1_BOVIN
Sequence: MERGPVVGAGRGAGARIRALLGGLVRVLLWVASALLYFGSEQAARLLGSPCLRRLYHAWLAAVVIFGPLLQFHVNPRTIFASHGNFFNIKFVNSAWGWTCTFLGGFVLLVVFLATRRVAVTARHLSRLVVGAAVWRGAGRAFLLIEDLTGSCFEPLPQGLLLHELPDRRSCLAAGHQWRGYTVSSHTFLLTFCCLLMAEEAAVFAKYLAHGLPAGAPLRLVFLLNVLLLGLWNFLLLCTVIYFHQYTHKVVGAAVGTFAWYLTYGSWYHQPWSPGSPGHGLFPRPHSIHKHN
What is the function of this protein?
Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity).  Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity).
What are the official names of this protein?
Fat storage-inducing transmembrane protein 1, Fat-inducing protein 1.
What is the protein family that this protein belongs to?
Belongs to the FIT family. FIT1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.