PharMolix/UniProtQA huggingface dataset:
Protein: GON7_CANGA
Sequence: MELCAEYVSPDQRRSFVAGPHGTTDGVTTGPSAYVLNAGQVDRDRPAEARSVAGKVTYLGQLRNQLTGLQDDINEYLTLRMEAAKSKKLKTADEQRIEKEINTLLDGGDDEE
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators (By similarity).
What are the official names of this protein?
EKC/KEOPS complex subunit GON7.
What is the protein family that this protein belongs to?
Belongs to the GON7 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: BN3D2_HUMAN
Sequence: MAVPTELDGGSVKETAAEEESRVLAPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFPESPENGPILGLDVGCNSGDLSVALYKHFLSLPDGETCSDASREFRLLCCDIDPVLVKRAEKECPFPDALTFITLDFMNQRTRKVLLSSFLSQFGRSVFDIGFCMSITMWIHLNHGDHGLWEFLAHLSSLCHYLLVEPQPWKCYRAAARRLRKLGLHDFDHFHSLAIRGDMPNQIVQILTQDHGMELICCFGNTSWDRSLLLFRAKQTIETHPIPESLIEKGKEKNRLSFQKQ
What is the function of this protein?
O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1 (PubMed:28119416, PubMed:31329584, PubMed:31919512).  Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416).  The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1 (PubMed:23063121).  Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145 (PubMed:23063121, PubMed:28119416).
What are the official names of this protein?
RNA 5'-monophosphate methyltransferase, BCDIN3 domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RABEK_HUMAN
Sequence: MKQLPVLEPGDKPRKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMSHSGDSHEESQTATLLCLVFGGMNTEGEIYDDCIVTVVD
What is the function of this protein?
Rab9 effector required for endosome to trans-Golgi network (TGN) transport.
What are the official names of this protein?
Rab9 effector protein with kelch motifs, 40 kDa Rab9 effector protein, p40.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane. Note=Interaction with PIKFYVE and subsequent phosphorylation recruits it to the endosomal membrane.
Protein: RNH2_SHIDS
Sequence: MIEFVYPHTQLVAGVDEVGRGPLVGAVVTAAVILDPARPIAGLNDSKKLSEKRRLALYEEIKEKALSWSLGRAEPHEIDELNILHATMLAMQRAVAGLHIAPEYVLIDGNRCPKLPMPAMAVVKGDSRVPEISAASILAKVTRDAEMAALDIVFPQYGFAQHKGYPTAFHLEKLAEYGATEHHRRSFGPVKRALGLAS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_PSEPF
Sequence: MKNWLDEIKWDADGLVPAIAQDHKTGRVLMMAWMNREALELTAAENRAIYWSRSRGKLWRKGEESGHVQTLHEMRLDCDADVIILMVEQIGDIACHTGRQSCFYRVFENGDWKTVDPVLKDPHAIYSAGHKHE
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIA4B_RAT
Sequence: MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGTLGGTHRVKLVPGYTGQQRLVKEGLSGKSCTCSRCMGDAGTSEWFDSHFDSNISPVWTRDNMNLTPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDILAKASKIEVYRGN
What is the function of this protein?
A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8144500).  Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage.  Sialylates GM1/GM1a, GA1/asialo-GM1 gangliosides to form GD1a and GM1b, respectively (PubMed:8144500).  Together with ST3GAL3, primarily responsible for biosynthesis of brain gangliosides that function as ligand for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity).  Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (By similarity).  Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8144500).
What are the official names of this protein?
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2, Alpha 2,3-ST 2, Beta-galactoside alpha-2,3-sialyltransferase 2, Gal-NAc6S, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, Monosialoganglioside sialyltransferase, ST3Gal II, ST3GalII, ST3GalA.2, Sialyltransferase 4B, SIAT4-B.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (By similarity). Secreted into the body fluid.
Protein: ING3_XENLA
Sequence: MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVGEFFMNAKKNKPEWREEQMASIKKDYFKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDTPSQPVNNHHVHSHSSGEKRKHIPSSHHSTTDHVPEKKFKSEALLSTLTSDASKENTAGCRTNLSSSSTNNVYNVNSSQPLTSYNISSLSTGAAAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNTDLLGISLSRDSASYSSSALASTLTQTLTSSATTDSRSGRKSKSNNKSASQQSSSSSSSSSLSSCSSSSALAHELSHQQTAAIPESDTNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLSEAPKGKWYCPQCTAAMKRRGSRHK
What is the function of this protein?
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity).  NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).
What are the official names of this protein?
Inhibitor of growth protein 3.
What is the protein family that this protein belongs to?
Belongs to the ING family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PP150_ARATH
Sequence: MLLLKQISPPFHLHQLRRRISTIISAGFTLNLPKLEPSSDAELISQMLITNHNPFHFMESSLQLNGISLTPNLIHQTLLRLRHNSKIALSFFQYLRSLPSPSTTPTSFNLIIDILGRVRQFDVVRQLIVEMDQTSPETFLILVKRLIAAGLTRQAVRAFDDAPCFLENRRFRLVEFGFLLDTLCKYGYTKMAVGVFNERKEEFGSDEKVYTILIAGWCKLRRIDMAEKFLVEMIESGIEPNVVTYNVLLNGICRTASLHPEERFERNVRNAEKVFDEMRQRGIEPDVTSFSIVLHMYSRAHKAELTLDKMKLMKAKGISPTIETYTSVVKCLCSCGRLEEAEELLETMVESGISPSSATYNCFFKEYKGRKDANGAMNLYRKMKNGLCKPSTQTYNVLLGTFINLGKMETVKEIWDDLKASETGPDLDSYTSLVHGLCSKEKWKEACGYFVEMIERGFLPQKLTFETLYKGLIQSNKMRTWRRLKKKLDEESITFGSEFQRYPFEPYKR
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g13420, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: BIOF_PSEA8
Sequence: MSFDLASRLASRRAEDLYRQRPLLESAQGPDVVVDGQPLLAFCSNDYLGLANHPEVIAALRAGAERWGVGGGASHLVVGHSGPHHELELALAEFTGRPRALLFSTGYMANLGAVTALVGKGDTVLEDRLNHASLLDAGLLSGARFSRYLHNDPASLAARLDKAEGNTLVVTDGVFSMDGNLADLPALAAVAQARGAWLMVDDAHGFGPLGASGGGIVEHFGLGQEQVPVLIGTLGKGFGTAGAFVAGSEELIETLIQYARPYIYTTSQPPAVACATLKSLELLRRESWRRQHLAALIARFRHGAEALGLTLMDSFTPIQPILVGGSRQAVALAGMLRARGIMVGAIRPPTVPANSARLRVTLSAAHSEAQVDRLLEALGESWRQLSSSLLAEIEAEEGDDA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: Y1349_STAA8
Sequence: MQIELTDAAVTWFKNELELPENNKVLVFFVRYGGEFQLKQGFSPAFTVEPKEDVDIGYEQQYDDLNVVVAEKDLWYFEDDHIIVNVVDHEDEISYSTK
What are the official names of this protein?
Uncharacterized protein SAOUHSC_01349.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: Y4563_DICDI
Sequence: MNKINNNNNNIHKLIKSLKIGNNDRINNNNNIINNNNIINNNNNDLLIEDDYFNGLLSTSPLPSQFNQLSSSPPSINSSLESIPMSPIRIQSNNVCPGAPIKPKKYLLPKSNYNLPRQRLVFTECVGSGSGSDSSSGSTSSPNTVNNYNSDDESNAAVVSFSPKVSKKLSQSSVQFIPSSSFRQMDSPSGNQNVPVFNSPKARKRLVF
What are the official names of this protein?
Putative uncharacterized protein DDB_G0292776.
Protein: PHNC_ECO57
Sequence: MQTIICVEQLSKTFNQHQALHAVDLNIHHGEMVALLGPSGSGKSTLLRHLSGLITGDKSAGSHIELLGRTVQREGRLARDIRKSRANTGYIFQQFNLVNRLSVLENVLIGALGSTPFWRTCFSWFTREQKQRALQALTRVGMAHFAYQRVSTLSGGQQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYALRYCERIVALRQGHVFYDGSSQQFDNERFDHLYRSINRVEENAKAA
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FSDC_FUSHE
Sequence: MDRPNKAIYLYQTSKGNHEIRTIQEPYVPKDAQSLVDVQYSGINPADTRHVYMDMSNYVAGYEFAGTVKQVGPKSPFKIGQEIFGISIPYNNRPNYLGAHQSFLLAENFMTFARPDHLDPITAATLLAGGGTAMDGLLNVLGYGFPPAGIPGDDPTNVPILIWGGAGGVGQAAVQLAKAAGFFPIITTASQQNHDVMKQLGASHVFNYKSPSVVQDIRNLLESKGWSLKTVFDAVSTGLGVFDGLTEEQEKAVQQKYNQSSSAMARQCCDPNIPDSELRLTSVLPVKMDPNYVFCLNFRPVEILDIGGEVTKDTKEEEMTKWKEWQPRIEKCIEWLIENHEKHWQPPRTRVVKGVEEGLQGIRDVWQGKMSREKLVIDHRV
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of fusaridione A, a bright yellow trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:23614392).  The PKS module of fsdS catalyzes the formation of the polyketide unit which is then conjugated to L-tyrosine by the condensation domain of the fsdS NRPS module.  Activity of the Dieckmann cyclase domain (RED) results in release of the intermediate fusaridione A (PubMed:23614392).  The unstable pyrrolidinedione ring of fusaridione A is opened through a reverse-Dieckmann reaction to afford its ring-opened form (PubMed:23614392).
What are the official names of this protein?
Trans-enoyl reductase fsdC, Fusaridione A biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: MRAY_SORC5
Sequence: MIYELFYPLKFHYGWLSWLNVLRYIPFRTIMATITAMVLTFVLAPWFIRELRRKQIGQVVRAEGPETHKIKAGTPTMGGALILLSLLLPTVLWADLRNPFVLATTAVTAGYGVIGYLDDFLKIKRRNSGGLPGRYKLIGQVLIGGAAVAYTFLLASKLPPDWAEIRTRLAIPFVAFSKYPIELPLYVYIPFAVFVVVATSNAVNLTDGLDGLAIGPVIINAGTYLILAYIVGASIASFSLATYLDIPAIASAGELSVYCGSVIGAGIGFLWYNTYPAQVFMGDVGSLALGGGLGMLAVFTKNELLSIILGGIFFIETVSVITQVLSFKLTGKRVFLMAPIHHHYEKKGWAEPKIIVRFWIISILLALVSLASMKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TPIS_MYCTU
Sequence: MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAGGPLP
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPMA_HAMD5
Sequence: MSEAANWQPSAPISNLLKRADMIKKIRQFFTDRGVLEVDTPCMSQATVTDVHLSTFETRFLAPTMAKSLSLYMTTSPEYHMKRLLAAGSGPIYQMGRCFRNEEMGRYHNPEFTLLEWYRPHYDMYRLMDEVDDLLQQILTCHSAETLSYQQAFLRHLNIDPLSADETQIKEAAVRLNLASITDNEKDRDTFLQLLFMAGVEPYIGRDKPVFIYHFPASQAALASISTEDYRVAERFEVYFKGIELANGFYELTDSAEQQQRFEQDNRQRAALGLPKRSIDERFIAALKHGLPPCSGVALGIDRLVMLSVNAENLSEVMAFPVERA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P).  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: EBP_MOUSE
Sequence: MTTNTVPLHPYWPRHLKLDNFVPNDLPTSHILVGLFSISGGLIVITWLLSSRASVVPLGAGRRLALCWFAVCTFIHLVIEGWFSLYNGILLEDQAFLSQLWKEYSKGDSRYILSDSFVVCMETVTACLWGPLSLWVVIAFLRQQPFRFVLQLVVSMGQIYGDVLYFLTELHEGLQHGEIGHPVYFWFYFVFLNAVWLVIPSILVLDAIKHLTSAQSVLDSKVMKIKSKHN
What is the function of this protein?
Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
What are the official names of this protein?
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, Cholestenol Delta-isomerase, Delta(8)-Delta(7) sterol isomerase, D8-D7 sterol isomerase, Emopamil-binding protein.
What is the protein family that this protein belongs to?
Belongs to the EBP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Cytoplasmic vesicle. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles.
Protein: EFTS_MYCSK
Sequence: MANYTAADVKRLRELTGAGMMASKNALVEADGDFDKAVELLRIKGAKDVGKRAERATAEGLVAAKDGALIELNSETDFVAKNAEFQSVADQIVAAAAAAKATDIDALKAAKVGDTTVEQVIADLSAKIGEKLELRRVAYFDGNVETYLHKRAADLPPAVGVLVEYTGDGENGTEAAHAVALQIAALKAKYLTREDVPEDVVANERRIAEETARNEGKPEQALPKIVEGRVTGFYKDVVLLDQPSVSDNKKTVKALLDEAGVTVTRFVRFEVGQA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_VIBC1
Sequence: MQTQRLRIAIQKKGRLSKESQALLKKCGVKFNVMGERLVVHSENMPIDLLLVRDDDIPGLIMDGVVDLGFIGENELEEVRLDRKALGEPYEFVQLRRLDFGGCRLSIAIDKDEEYNGPQDLAGKRIATTYPQLLKAYMDEVGVPFSTCMLTGSVEVAPRAGLADAIADLVSTGATLEANGLKEAEIIFKSKATLIQRTGEFDADKVALIEKLLTRMQGVQQAKESKYIMLHAPAEKLDQIKALLPGAEDPTVLPLSADKQKVAVHLVSTENLFWETMEQLKELGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAP2_ARTOC
Sequence: MKTQLLSLGVALTAISQGVIAEDALNWPFKPLVNADDLQNKIKLKDLMAGVQKLQDFAYAHPEKNRVFGGAGHKDTVDWIYNELKATGYYDVKMQPQVHLWSHAEAAVNANGKDLTASAMSYSPPADKITAELVLAKNMGCNATDYPEGTKGKIVLIERGVCSFGEKSAQAGDAKAIGAIVYNNVPGSLAGTLGGLDNRHAPTAGISQADGKNLASLVASGKVTVTMNVISKFENRTTWNVIAETKGGDHNNVIMLGSHSDSVDAGPGINDNGSGTIGIMTVAKALTNFKVNNAVRFGWWTAEEFGLLGSTFYVDSLDDRELHKVKLYLNFDMIGSPNFANQIYDGDGSAYNMTGPAGSAEIEYLFEKFFDDQGIPHQPTAFTGRSDYSAFIKRNVPAGGLFTGAEVVKTAEQAKLFGGEAGVAYDKNYHGKGDTVDNINKGAIYLNTRGIAYATAQYASSLRGFPTRPKTGKRDVSPRGQSMPGGGCGHHSVFM
What is the function of this protein?
Extracellular aminopeptidase that releases a wide variety of amino acids from natural peptides and contributes to pathogenicity.
What are the official names of this protein?
Leucine aminopeptidase 2, Leucyl aminopeptidase 2, LAP2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28A subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ADC_PARXL
Sequence: MDVKSVLSNAFAMPITSPAFPMGPYRFINREFLIITYRTDPDKLRAVVPEPLEIGEPLVHYEFIRMPDSTGFGDYTESGQVIPVSYKGVAGGYTLAMYLDDHPPIAGGRELWGFPKKLANPVLAVHTDTLVGTLDYGPVRIATGTMGYKHRQLDLAQQKKRLETPNFLLKVIPHVDGTPRICELVRYYLQDIDLKGAWTGPAALELAPHALAPVAALPVLEVVEARHLIADLTLGLGEVVFDYLGQPQANAR
What is the function of this protein?
Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.
What are the official names of this protein?
Acetoacetate decarboxylase, AAD, ADC.
What is the protein family that this protein belongs to?
Belongs to the ADC family.
Protein: HDA1B_XENLA
Sequence: MALSQGTKKKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKASAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDISVNWSGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVVYIDIDIHHGDGVEEAFYTTDRVMSVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMTKVMEMFQPSAVVLQCGADSLSGDRLGCFNLTIKGHAKCVEFIKTFNLPMLMLGGGGYTIRNVARCWTYETAVALDSEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDSVHDDSGEEDEEDPDKRISIRSSDKRIACDEEFSDSEDEGEGGRKNVANFKKVKRVKTEEEKEGEDKKDVKEEEKAKDEKTDSKRVKEETKSV
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10454532).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10454532).  Histone deacetylases act via the formation of large multiprotein complexes (By similarity).  Also functions as deacetylase for non-histone proteins.  In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (By similarity).
What are the official names of this protein?
Probable histone deacetylase 1-B, HD1-B, Protein deacetylase HDAC1-B, Protein decrotonylase HDAC1-B, RPD3 homolog.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: YACG_SALHS
Sequence: MSDVTVVNCPTCGKPVVWGEISPFRPFCSKRCQLIDLGEWAAEEKRIASSGDQSDSDDWSEER
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: AHY_SYNAC
Sequence: MASKKHVVCQSCDINCVVEAEVKADGKIQTKSISEPHPTTPPNSICMKSVNADTIRTHKDRVLYPLKNVGSKRGEQRWERISWDQALDEIAEKLKKIIAKYGPESLGVSQTEINQQSEYGTLRRFMNLLGSPNWTSAMYMCIGNTAGVHRVTHGSYSFASFADSNCLLFIGKNLSNHNWVSQFNDLKAALKRGCKLIVLDPRRTKVAEMADIWLPLRYGTDAALFLGMINVIINEQLYDKEFVENWCVGFEELKERVQEYPLDKVAEITGCDAGEIRKAAVMFATESPASIPWAVSTDMQKNSCSAIRAQCILRAIVGSFVNGAEILGAPHSDLVPISKIQMHEALPEEKKKLQLGTETYPFLTYTGMSALEEPSERVYGVKYFHNMGAFMANPTALFTAMATEKPYPVKAFFALASNALMGYANQQNALKGLMNQDLVVCYDQFMTPTAQLADYVLPGDHWLERPVVQPNWEGIPFGNTSQQVVEPAGEAKDEYYFIRELAVRMGLEEHFPWKDRLELINYRISPTGMEWEEYQKQYTYMSKLPDYFGPEGVGVATPSGKVELYSSVFEKLGYDPLPYYHEPLQTEISDPELAKEYPLILFAGLREDSNFQSCYHQPGILRDAEPDPVALLHPKTAQSLGLPSGEWIWVETTHGRLKLLLKHDGAQPEGTIRIPHGRWCPEQEGGPETGFSGAMLHNDAMVLSDDDWNLDPEQGLPNLRGGILAKAYKC
What is the function of this protein?
Catalyzes the hydration of acetylene to form acetaldehyde.  Ethylene cannot act as a substrate.
What are the official names of this protein?
Acetylene hydratase, Ahy.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
Protein: NHAA_KORVE
Sequence: MSEAFDSRASKALPIEVLISPFVRFARMEAASGILLIVSTAAALVWANSPWKSSYDAIWDVPMVAGVGNFLLTESRHHWINDGLMSIFFFLVGLEIKREVLIGELTSLRNAAFPLIAAVGGTVVPAVIYLLCVGGGVAQKGWGIPMATDIAFALGVLILLGNRIPPSLRVFVTALAIVDDIIAVLVIALFYTHEIHLVSLLVALGGVGIAFGFNLLGISKPSVYALIGVCIWAAVLKSGVHATVAGVLLAFTIPARNYLDRDFFVKRGRWLLERFEKSEPHSFESHTAIHTLQHQCDMIESPLHRLEHGLQPWVSFLIMPLFAFSNAGVRFIGNIGVAVKHPVSIGVALGLFLGKPLGIWLFAWLAVKSRVANAPPELSWWQIFGASWICGIGFTMSLFIASLAFGYGNLLDMSKIGTLAASLVAGVCGSVVLWRRSALGTSEPPVSPATTSASV
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.