PharMolix/UniProtQA huggingface dataset:
Protein: GEN_HUMAN
Sequence: MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKPHLRNLFFRISYLTQMDVKLVFVMEGEPPKLKADVISKRNQSRYGSSGKSWSQKTGRSHFKSVLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRWNETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHDRQLSEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFTLEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHYAMEDKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQKRIKPKENNLPEPDEVMSFQSHMTLKPTCEIFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTPCLNAQEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPAIQRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDEDSDGISPEEHLLSGITDLCLQDLPLKERIFTKLSYPQDNLQPDVNLKTLSILSVKESCIANSGSDCTSHLSKDLPGIPLQNESRDSKILKGDQLLQEDYKVNTSVPYSVSNTVVKTCNVRPPNTALDHSRKVDMQTTRKILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKLSSPKIHIKETEQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLRQRLKLRFQST
What is the function of this protein?
Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated.  Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650).  Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products.  Cleavage of the first strand is rate limiting, while second strand cleavage is rapid.  Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604).  Efficiently cleaves both single and double HJs contained within large recombination intermediates.  Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubMed:28049850).  Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates (PubMed:26578604).
What are the official names of this protein?
Flap endonuclease GEN homolog 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: WAKLJ_ARATH
Sequence: MSSNCSCSLLSLFSLLLIIDLTVASSCPKTCGGIDIPYPFGIGTGCYLEKWYEIICVNNSVPFLSIINREVVSISFSDMYRRFFNVGYGSIRIRNPIASKGCSSGGQEFGSLLNMTGYPFYLGDNNMLIAVGCNNTASLTNVEPSIVGCESTCSTNQDIPINDYLGVLYCNARYGDSEYCKNISIMNDTSCNGIGCCKASLPARYQQIIGVEIDDSNTESKGCKVAFITDEEYFLSNGSDPERLHANGYDTVDLRWFIHTANHSFIGSLGCKSIDEYTILRRDNREYGIGCLCDYNSTTTGYATCSCASGFEGNPYIPGECKDINECVRGIDGNPVCTAGKCVNLLGGYTCEYTNHRPLVIGLSTSFSTLVFIGGIYWLYKFIRRQRRLNQKKKFFKRNGGLLLQQQLTTTEGNVDSTRVFNSRELEKATENFSLTRILGEGGQGTVYKGMLVDGRIVAVKKSKVVDEDKLEEFINEVVILSQINHRNIVKLLGCCLETDVPILVYEFIPNGNLFEHLHDDSDDYTMTTWEVRLRIAVDIAGALSYLHSAASSPIYHRDIKSTNIMLDEKHRAKVSDFGTSRTVTVDHTHLTTVVSGTVGYMDPEYFQSSQFTDKSDVYSFGVVLAELITGEKSVSFLRSQEYRTLATYFTLAMKENRLSDIIDARIRDGCKLNQVTAAAKIARKCLNMKGRKRPSMRQVSMELEKIRSYSEDMQPYEYASENEEEKKETLVDVNVESRNYVSVTAASSQYSIATTSSSRSDVEPLFPR
What is the function of this protein?
Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component.
What are the official names of this protein?
Wall-associated receptor kinase-like 10.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: FIXA_SINFN
Sequence: MHIVVCIKQVPDSAQIRVHPVTNTIMRQGVPTIINPYDLFALEQALQVRDHHGGEVTVLTMGPPMAEESLRKALTYGADRAILLTDRHFAGSDTLATSFALSQAIAKIGNSFGSPDIVFTGKQTIDGDTAQVGPGIAKRLDLVQLTYVAKVTSIDLRTRAITVERRAEGGTHVLKSELPCLITMLEGSNAIRRGSLDDALRAARSEIVKWNAVEAGIEDITKCGLRGSPTVVKRVFAPTPREQKAVQIDTVEKAMQDVANELVTSIFAHQPALEHELSSTRSVSR
What is the function of this protein?
May play a role in a redox process involved in nitrogen fixation.
What are the official names of this protein?
Protein FixA.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: OLE_LILLO
Sequence: MAERQTGTGPGPVTRTHRHHAPASGGACSNLLRRIQDHVPNSTQLVGFLTLLISGGILLLLTGLTATSAAMGFVLFAPLILLTSPVWIPLVTIFFLLTAGFLSTCGFGVAALAGGTWLYRYLSGRHPLGSERVDYARSRIADTASHVKDYAREYGGYLQSRVKDAAPGA
What are the official names of this protein?
Oleosin.
What is the protein family that this protein belongs to?
Belongs to the oleosin family.
What are the subcellular locations of this protein?
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface.
Protein: SELA_CAMJE
Sequence: MNKFRTFPQINTLIEDESLKSYPFYIKAFFCKKVVAKLKENFFQDEISKDKLLLEIKKEIKTFYRKDLQSVINASGVVIHTNLGRSVIHEELYEACKDIICNYSNVEFDLENGKRGSRYALVLEKLKMLFECEDALVVNNNAAAVFLVLNSLCYDKEVISSRGELVEIGGSFRVPEVIKAAGVKLCEVGTSNKTHLKDYEQAINENTALILKTHKSNFALMGFHSEVNIKDLHELAKEKELLSYYDLGSGWCENLNEKLIKNEPKIRKLVQECDILSFSGDKLFGSVQAGIILGKKELIEKLKQNQLLRMLRVDKLTLSFLNESLKAYLQKDYEKIITLKLLNDDLSFIEKKALRVQKELKFQTQLKKSKSLVGGGSMPDKSLDTYILTFQGDALKLQTRFRKENIIGRIENDEFVLDFRTIRENELQKLILTINQMENL
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSGA_ECOBW
Sequence: MSKNKLSKGQQRRVNANHQRRLKTSKEKPDYDDNLFGEPDEGIVISRFGMHADVESADGDVHRCNIRRTIRSLVTGDRVVWRPGKPAAEGVNVKGIVEAVHERTSVLTRPDFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIVLNKIDLLDDEGMAFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGLQKEILTNDISDNSGLGQHTTTAARLYHFPHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGLCKYRDCKHDTDPGCAIREAVEEGKIAETRFENYHRILESMAQVKTRKNFSDTDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYNPR_RAT
Sequence: MCMVIFAPLFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALVGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQRYLSDPMEKHSSSYNQGGYNQDSYGSSGGYSQQASLGPTSDEFGQQPSGPTSFNNQI
What is the function of this protein?
Intrinsic membrane protein of small synaptic vesicles.  Probable vesicular channel protein.
What are the official names of this protein?
Synaptoporin.
What is the protein family that this protein belongs to?
Belongs to the synaptophysin/synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Synapse, synaptosome.
Protein: YBEY_ECO57
Sequence: MSQVILDLQLACEDNSGLPEESQFQTWLNAVIPQFQEESEVTIRVVDTAESHSLNLTYRGKDKPTNVLSFPFEVPPGMEMSLLGDLVICRQMVEKEAQEQGKPLEAHWAHMVVHGSLHLLGYDHIEDDEAEEMEALETEIMLALGYEDPYIAEKE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB4_SCHPO
Sequence: MESLLAVQGQDFVLTASSSSAVRGITVLKPDDDKSQILNSHNLMLYCGEAGDTTNFAEYIAANISLYTLRHNLNLSPEATASFTRKQLATSLRSRKPYQVNILLAGYETNLGKPELFWLDYLATCVRVPYACQGYSSFYCLSIFDRYYKPDLTIDEAVRIMKLCFDELKKRMPIDFKGFICKVVDKDGIREINI
What is the function of this protein?
Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity (By similarity).
What are the official names of this protein?
Probable proteasome subunit beta type-4.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y2216_STAAB
Sequence: MLYPIFIFILAGLCEIGGGYLIWLWLREGQCSLVGLIGGAILMLYGVIATFQSFPSFGRVYAAYGGVFIIMSLIFAMVVDKQMPDKYDVIGAIICIVGVLVMLLPSRA
What are the official names of this protein?
UPF0060 membrane protein SAB2216c.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACSA_SALTI
Sequence: MSQTHKHAIPANIADRCLINPEQYETKYKQSINDPDTFWGEQGKILDWITPYQKVKNTSFAPGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDASQSKHISYRELHRDVCRFANTLLDLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAIAGRIIDSSSRLVITADEGVRAGRSIPLKKNVDDALKNPNVTSVEHVIVLKRTGNDIDWQEGRDLWWRDLIEKASPEHQPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGKEKCPVVDTWWQTETGGFMITPLPGAIELKAGSATRPFFGVQPALVDNEGHPQEGATEGNLVITDSWPGQARTLFGDHERFEQTYFSTFKNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHAIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEEKQAIAMPS
What is the function of this protein?
Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt.  Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: METN_MYCSS
Sequence: MIEIDNLTKRFGDRTVLDDISLSVGAGEILAVVGPSGAGKSTLSRCVSFLERPTSGSVRVDGADFTRLEGDALIAARRKIGVIFQTAPLLRRRTVAQNVALPLEYLRATDDSVSRRVTELLDRVGLRDRSGYHPAQLSGGQRQRVGIARALALGPSVLLSDEATSGLDPATTKSILALLSHLREDFGLSIILITHEMEVVREIADSVARIDDGRIVESGSVTDVILDPTSALARELLPERPSVPVRGDAEVWEVSHASRHVPLDWLTSIQSVPGISGVQVDVLSASVEAIRGVAVGRAVLAISPAAPPGFADHLSARGLHVTSTAATARKTAA
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: WXCX_XANCP
Sequence: MSTLDRSIQARARAHLFGLLRAGFRVIPLSDATRDRWRSWFLDRHADWVPEPVRGRANHAISRRPTARSDEAAIGHVAYRTIALPETLPATLVAFYLPQFHPIPENDAWWGKGFTEWRNVSRTLPQFEGHQQPRLPADLGFYDLRTPDVMREQARLAQEYGLGAFCFYFYWFAGKTLLEMPITQWHADTSITLPFCLCWANEKWARRWDGRGHDVLIDQAHSADDDLAFIAHVARYMRNPKYLRVGDRPLLLVYRPHLLPEPVQTAARWRNWCRDNGIGEIHLAYVQGFERPDPRDIGFDAAVEFPPNMSTPPSVTARQRLVNPDFSGDVLDWRELARDMEQRPLRDYTLYPGVNPGWDNEPRRSGKGRIYLHASPRRYRDWLARTVQHRLANAPSAHRMVFINAWNEWAEGAVLEPDARLGYAWLDATRQALTRAPDVATEICSPSACVVLHAWYLDVLDEMLDAIVECGTPLRIIITTDLTKVIEVTKCIQRRGIQAEVEGFENRGRDILPFLHVANRLLDENVQLVLKLHTKKSTHRDDGNAWRGEMLTALLGPQRVDAIVNAFSTDPLAGLAAPEDHLLPVTEFIGGNADALDYLTVRTGSDAPDTNSLFASGSMFWARLEALRPLLDAHLHASEFESEQGQIDGTLAHAIERFVGLAVTHSGHRVTTVEQTLGITKTPSAQPYRYARKAP
What are the official names of this protein?
Uncharacterized protein WxcX.
Protein: RDC2_METCM
Sequence: MSVPKSCTILVAGGGPAGSYAAAALAREGNDVVLLEADQHPRYHIGESMLPSLRPLLRFIDLEDKFDAHGFQKKLGAAFKLTSKREGSHGPRGYSWNVVRSESDEILFNHARESGAQAFQGIKINAIEFEPYEEEYPNGEKVANPGKPTSAKWSSKDGSSGDIAFKYLVDATGRIGIMSTKYLKNRHYNEGLKNLAIWGYYKNNIPWAQGTPRENQPFFEGMRDGAGWCWTIPLHNGTVSVGAVMRKDLFFEKKKSLGENATNTQIMAECMKLCPTIGELLAPAELVSDIKQATDYSYSATAYAGPNFRIVGDAGCFIDPFFSSGHHLAVAGALAAAVSINASIKGDCTEYEASRWHAKKVDEGYTLFLLVVMAALKQIRMQENPVLSDVDEDGFDRAFQFLRPEAVKKFTKEDVAQTIDFAVHALNNMAELDMDIPEHMINGDKEGENGVTNGNNGAAKTAGLASNMEKLTNDEEKVLNGLRILGKAAPGGTLADFEGTAIDGLMPRLEHGKLGLNKV
What is the function of this protein?
Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of radicicol, a resorcylic acid lactone (RAL) that irreversibly inhibits the HSP90 molecular chaperone, an important target for cancer chemotherapy (PubMed:18567690).  Within the cluster, rdc2 is involved in the chlorination of the resorcylic acid lactone (RAL) structure to convert monocillin I into radicicol (PubMed:18567690, PubMed:20827793).  Also chlorinates monocillin II to produce 6-cholomonocillin II and monocilllin IV to produce 13-chloromonocillin IV (PubMed:20827793, PubMed:23312946).  In contrast to most fungal halogenases, rdc2 has a broad substrate specificity and can accept a variety of macrolactones as the substrates to generate chlorinated derivatives, including dihydroresorcylide, zearalenone, curvularin, or even curcumin (PubMed:20827793).  Rdc2 is able to dichlorinate dihydroresorcylide and monocillin IV (PubMed:20827793).  Dihydroresorcylide is first chlorinated at position 11 to produce 11-chlorodihydroresorcylide which can be further chlorinated by rdc2 at possition 13 (PubMed:20827793).  Mororeover, rdc2 can incorporate bromine into dihydroresorcylide to yield the corresponding mono- and di-brominated derivatives (PubMed:20827793).  Finally, rdc2 is also able to halogenate the isoquinolines 4-hydroxyisoquinoline and 6-hydroxyisoquinoline into 3-chloro-4-hydroxyisoquinoline and 5-chloro-6-hydroxyisoquinoline, respectively (PubMed:23312946).  The radicicol cluster encodes only two apparent post-PKS enzymes, a cytochrome P450 monooxygenase (rdc4) and a non-heme halogenase (rdc2) that could introduce the epoxide and the chlorine, respectively.  If this cluster includes all the genes required for radicicol biosynthesis, the remaining structural features of radicicol are presumably generated by the PKSs rdc1 and rdc5.  The C-2' ketone could arise if the R-PKS rdc5 and NR-PKS rdc1 each carry out four iterations, in contrast to the five iteration-three iteration split for the hypothemycin PKSs.  The origin of the cis 5',6' double bond is not known.  The radicicol R-PKS rdc5 ER domain may catalyze either double bond isomerization or reduction in the third iteration (PubMed:18567690) (Probable).
What are the official names of this protein?
Flavin-dependent halogenase rdc2, Hypothemycin biosynthesis cluster protein rdc2, Non-heme halogenase rdc2.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: RS20_PARPJ
Sequence: MANSAQARKRARQAAKANSHNSALRSKFRTAIKAVRKAIDAGDKAKAAEIFQASSKTIDIIADKNIVHKNKAARHKSRLAAAIKGLQASAAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: NUON_TOLAT
Sequence: MSFNSVLFIAELPLLLTALTAIAVMLSIAWQRNHKQVFYITVIGLNAALFSLLPASSATPVTVTPLLIVDSYSVFYSALILIGSLATVTLARAWLKKFPDNREEFYLLLSLASTGAMVMAQAHHLAAIFIGVELMSLPLFGLVGYAFRQRRSLEAAVKYMVLSASATAFLLFGIALIYAQVGSLDIATIGAQISRLPQAESAHITLLIVGLGMVVIGFGFKLSLVPFHLWTPDVYQGAPAPVTTYLATVSKIAVFAVLLRLFYTIPATDSFFYSLLGGLAFISIIIGNLLALLQSNLKRLLGFSSTAHFGYLLVALIACRLGSLSQEAVALYLVMYLLTSVGSFGVVSLMSSPYQERDADELPAYRGLFWRRPILTSAMTIMFLSLAGIPMTLGFIGKFYILAVGIQFHLWWLTGAVVFGSAVGLYYYLRVISILYLKTPGMPSRDATNDWALTTGGFMVLTSAILVVLLGIYPQPLLDLLPLAQLATP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VE1_HPV35
Sequence: MADPAGTDEGEGTGCNGWFFVEAVVSRRTGDPVSEDENEDDCDRGEDMVDFINDTDILNIQAETETAQALFHAQEEQTHKEAVQVLKRKYASSPLSSVSLCVNNNISPRLKAICIENKNTAAKRRLFELPDSGYGNSEVEIQQIQQVEGHDTVEQCSMGSGDSITSSSDERHDETPTRDIIQILKCSNANAAMLAKFKELFGISFTELIRPFKSDKSTCTDWCVAAFGIAPSVAESLKTLIKPYCLYIHIQCLSCSWGMVILALLRFKCAKNRTTIEKLLSKLLCISAASMLIQPPKLRSTPAALYWFKTAMSNISEVDGETPEWIQRQTVLQHSFNDAIFDLSEMVQWAYDNDFIDDSDIAYKYAQLAETNSNACAFLKSNSQAKIVKDCATMCRHYKRAEKREMTMSQWIKRRCEKVDDDGDWRDIVRFLRYQQVDFVAFLSALKNFLHGVPKKNCILIYGAPNTGKSLFGMSLMHFLQGAIISYVNSKSHFWLQPLYDAKIAMLDDATSPCWAYIDQYLRNALDGNPISLDVKHKALVQLKCPPLLITSNINAGKDDRWPYLHSRVVVFTFHNEFPFDKNGNPVYGLNDKNWKSFFSRTWCRLNLHEEEDKENDGDAFPAFKCVSGQNTRTLRD
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: Y3103_BRADU
Sequence: MTAAPKRPSGQEGFFWKTKTLEEMSGAEWESLCDGCGRCCLNKLEDEDTGDIYFTHVGCKLLDAGTCGCKDYPNRSDKVPDCVRLTPANVRTLNWLPPSCGYKLVAEGRDLYWWHPLVSGDPNTVHEAGVSVRGRVEGSEEEIPDADLEDHIVQWPALLPKRARLKRRPKD
What are the official names of this protein?
UPF0260 protein blr3103.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: KSBGL_SPHMU
Sequence: MRKTKFWLVLSLIATSLSIFACKKDSTATKNPIPEVSKAKASTKLLNATTVATTDYELIWSDEFNSSGGFDSTKWSYADRGTVAWNKYMTSLPAYASQDGSNLVLRMDNAVVAGDPVAYHAGGVKSMGKFSMTYGKVEVRAKFTQGRGSWPAIWMMPEPATAYGGWPSCGEIDSMEHVNNESVMYHTIHNGSVTNANGGSTASKSATYNTTDYNLYTMIWSPNDIRFYVNNSLQYTYARVSGGGTQQWPFDVPFYLILNQAGGAGWPGAITNADLPFSMQVDYVRVYKLPLFSNGDFESGVIYPWTTWGGGSSVVSTDARTGTKCIRETGGETSIEQYLTGLTPNTTYRFGGYAKVSAAGQSVSIGVKNYGGTAVDATIGTTSYSNNSVTFTTGANNTTATVYFYKPLSGTVYGDDFYLEKL
What is the function of this protein?
Hydrolyzes internal endo-beta-galactosyl linkages in keratan sulfate and in various neolacto-type glycosphingolipids, producing sulfated and non-sulfated disaccharides, and glucosylceramides respectivly.
What are the official names of this protein?
Keratan-sulfate endo-1,4-beta-galactosidase, Endo-beta-galactosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPF_XANOM
Sequence: MDITLTIFAQALAFAGLIWIVATKIWPPLLQAIEERQQKIAEGLAAADRSQKDLAQAQEKVNEVLKDARTKANEIIDQAHARANQIIEAAKLEAIAEANRQKELAQTEIDASATRAREELRKQVSVLAVSGAEKLLKREIDANAHKALLDELAAEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NU3C_NICTO
Sequence: MFLLYEYDFFWAFLIISILVPILAFLISGVLAPISKGPEKLSTYESGIEPMGDAWLQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSVFIEAFIFVLILIIGLVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: AA2BR_BOVIN
Sequence: MPLEAQDAVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFAIPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGARARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVGIFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTFHKIISRYILCRTHILKSGEGQVGSQPTLQLGL
What is the function of this protein?
Receptor for adenosine.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
What are the official names of this protein?
Adenosine receptor A2b.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIMM_SHEHH
Sequence: MSSKQEPVILGKLGSSFGIKGWLKITTYTDSVEGIFDYSPWLIKEQGEWREVKVAQWRFQGKAVVACLEGVTTRDEAQALTNCEIAVPAEQMQDLPEDEFYWRDLIGCEVINTKGYNMGTVQEIVETGSNDVLLVKANAKDGFGKAERMIPFVTDQFIQKVDLAAKQILVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_BORHD
Sequence: MIIAIDGPSASGKSSIAKALGSRLGFKFISSGYFYRIITLIAQKFTLNEYDLLSESKILELVLQNDIKFNGVDFLLNGVNVTSHILNERIDLQVSLYSSYIGVRNIVNKKLREIVKLKDDNYIIEGRDITTVVFPEAKVKIYLDASVKVRALRRYNQRDDDITLNELEQALERRDEIDQNKEYGKLKLAKEVFYIDTSYKCLDDVCDIIIKTFNLKKK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.