PharMolix/UniProtQA huggingface dataset:
Protein: VKT4_CYRHA
Sequence: MGTARFLRAVLLLSVLLMVTFPALLSAEHHDGRVDICRLPSDSGECSRFFGMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Serine protease inhibitor that inhibits trypsin and blocks voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hhn1d, U15-theraphotoxin-Hhn1d, Kunitz-type serine protease inhibitor hainantoxin-XI-4, HNTX-XI-4.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 03 (sub-Kunitz) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CSPLM_SORBI
Sequence: MVAARVSEVKAEGVLRGACAALAAAAALLVGLSTQTETVLLVRKKATVKDVQALWVLAMAAAAAAGYHLLQLLKCFYLGRRVGGGASPCRRSSRALAWTCLLLDKACAYTTFATTVAAAQACVIALDGAHALQWTKLCNIYTRFCEQIAGSLVLGMLAAVGTAVLSAASARNVFRHYSPGTYAAH
What are the official names of this protein?
CASP-like protein 2C1, SbCASPL2C1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SK1_PANVI
Sequence: EQFEDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, PanVi-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL193_ARATH
Sequence: MVSLKLQKRLASSVLKCGKRKVWLDPNEGSDISMANSRQNIRKLVKDGFIIRKPTKIHSRSRARQLNIAKRKGRHSGYGKRKGTREARLPTKVLWMRRMRVLRRLLKKYRETKKIDRHMYHDMYMKVKGNVFKNKRVLMESIHKSKAEKAREKTLSDQFEAKRAKNKASRERKHARREERLAKGPGGDIPAAAPPAQTAEVPAKKSKK
What are the official names of this protein?
60S ribosomal protein L19-3.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL19 family.
Protein: RL33B_YEAST
Sequence: MAESHRLYVKGKHLSYQRSKRVNNPNVSLIKIEGVATPQEAQFYLGKRIAYVYRASKEVRGSKIRVMWGKVTRTHGNSGVVRATFRNNLPAKTFGASVRIFLYPSNI
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L33-B, L37, Large ribosomal subunit protein eL33-B, RP47, YL37.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL33 family.
Protein: RLMN_XANCB
Sequence: MNEVAIPSVLLDVPVPAATVHKQNLLDLDREGLEHFFADTLGEARYRAHQMMKWIHHRYVTDFDQMTDLGKALRAKLHQHAEVLVPNVVFDKPSTDGTHKWLLAMGTDGKNAIETVYIPDKGRGTLCVSSQVGCGLNCTFCSTATQGFNRNLTTAEIIGQVWVAARHLGNVPHQQRRLTNVVMMGMGEPLMNFDNVVRAMSVMRDDLGYGLASKRVTLSTSGLVPMIDRLATESDVSLAVSLHAANDALRESLVPLNKKYPIAELMESCARYLRGNKKRDSVTFEYTLMKGINDQPEHARQLARLMRQFDNAVQSKDAGKVNLIPFNPFPGTRYERSGETEIRAFQKILLDAQVLTMVRRTRGDDIDAACGQLKGQVMDRTRRQAEFRRTLEGQADRDAAA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASZ1_MOUSE
Sequence: MAAGTLRGLAVAGGGESSDSEDDGWDIGYLDRSSQKLKRSLPVEEKNETFKKALTTGDISLVKELLDSGINVDSSFRYGWTPLMYAASVANAELVRFLLDRGANASFDKDKLTILISACSARGSEEQVLKCVELLLSRNADPNTACRRLMTPIMYAARDGHTQVVALLVAHGAEVNAQDENGYTALTWAARQGHKNVILKLLELGANKMLQTKDGRTPSEIAKRNKHLEIFNFLSLTLNPLEGKLQQLTKEETICKLLATDSDKEKDHIFSPYTAFGDLEIFLHGLGLEHMTDSLKEKDITLRHLLTMKKDELTKNGIASKDQQKILAALKELEVEEINFGKLPEVTKLEISGDEFLNFLLKLNKQCGHLITAVQNIITELPVNSHKIVLEWASPRNFTSVCEELVSNVEDLNEEVCRLKELIQKMQNERENDPTHIPLVEEVSTWKTRILKRSAVTVCGFGLLLFIGKLTLQRK
What is the function of this protein?
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process.  Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons.  May act by mediating protein-protein interactions during germ cell maturation.
What are the official names of this protein?
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1, Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein.
What are the subcellular locations of this protein?
Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to pi- bodies, a subset of the nuage which contains primary piRNAs.
Protein: HEM3_CLOBL
Sequence: MNFIIATRRSKLAQVQTEIIIDLLNKKHDIECEKLLIETVGDKILEVSLDKIGGKGLFVKDIEVAMLEQRADAAVHSMKDVPYEMPKGFEIIAIPKREDVRDAFISLDNIKFKDLRKGAKIGTSSRRRAAQLKLLRPDLDIVPIRGNVQTRIEKIKKENLDGIILAVAGLKRVNLEHLITDYFDTKEMVPAIGQGALGIEVMEEHPKKELFKDLDHYNSKICVLAERAFMRELDGDCHSTIGAYASIKDNIMHIIGIFERKNKIIKKEITGTKDQYEKLGIALAEHILKD
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: TMCAL_LACLA
Sequence: MNKITGIIAEFNPFHKGHEYLLNQIEGIKIVAMSGNWMQRGEPAIFDKWTRAQMALACGADLVVELPVTVSAQAADFFASGAVDILKNLGITDLAFGSESAIDYNEIADIYEKRGEEMESYIQSLADQLSYPEKTQKMWQHFTGIEFDGNTPNHVLALAYAKAAAGKQINLQAIKRVGKFHSLELTEGFASATALRQELFSLTERQNLLTEQTNQSVSNKLVLTDLSAIKNHVPSAILAAYASPKTNWAAYFPLLQYKIRVDEHLENIFQVNQELSVRLKKAVKSAKNFDELVEQVYTKRYTKARVRRLLTYILLNIPKQFDLPEQIHVLGFSKTGQEILAQNRGKIISKIGQNPWDNLTQKADEIYQLGNVQFEEQNFGRKPIRSSIR
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPSP3_ARATH
Sequence: MAKIVILFDFDRTLIDGDSDNWVVTEMGLTEIFHQLRFTLPWNRLMDRMMMELQSQGRSIDDIKSCLKKMPIDSHIIEAIKSAKSSGCDLKIVSDANQFFIEKILEHHDLVDCFSEIYTNPTSLDDNGNLRILPYHSDALPPHSCNLCPSNLCKGLVMDHLRASSSNDQIPRRFIYLGDGGGDFCPTLKLRECDFVMPRTNYPLWKKISDNPLLIKAEVKEWSSAEEQQRILLQLVSTITKEEDS
What is the function of this protein?
HAD-like hydrolase that has a thiamine monophosphate phosphatase activity in a heterologous system (PubMed:26537753).  Does not contribute to thiamine monophosphate phosphatase activity in planta (PubMed:27677881).
What are the official names of this protein?
Thiamine phosphate phosphatase-like protein.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily.
Protein: TOLB_SHEPC
Sequence: MKILAKWLALAVLLCTTPTKAALDIVITEGIDAARPIAVMPFVWQGTGAPPQAIADVVMSDLVRSGTFKPLDELGLPQRNIGAVAQFQASAWGSVGAEALVLGSVKPYGTDQYLVSFDLIDLVKAQNQSLKGAVSPTEFLMDSRQTVISAAQFRQYGHRISDIVYEKLTGIRGAFLTRISYVVVNHTQKAPYQLMIADYDGFNEQMLLRSPEPLMSPTWSPDGRRLAYVSFENKKAEIFVQDLYTQVRTKVSSFPGINGAPAFSPDGKSLAVTLSKDGQPEIYVIDIATKAIKRITNHYAIDTEPSWYPDGKSLLFTSERGGKPQLYRVDLASGKVTRETFEGEWNLGGSITPDGRSMIFVNRTNGKFNIARMDLNTRFMQVLTSTRLDESPSVAPNGTMVIYGTTHQGKQVLAAVSTDGRFKARLPVGQGEVKSPSWSPFL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MIAA_ECOBW
Sequence: MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ARGB_LISMH
Sequence: MENTIVIKLGGVASDNLTEGFFRQITEWQAANKKIVLVHGGGHYITKMMEALAIPVETKNGLRITNKAALEVTKMVLIGQVQPAITTAFQKRNISVIGLNAGDTGLLEADRLSDTDLGLVGKITKVKTNLIEQLLSENIITVIAPLGINSEHDWLNVNADTAACEVASALHAEALYLLTDVPGVKNGSEIINEIATAEIEKLQKTGVIKGGMIPKLASAAFAAENGVDQVIITNSLETIGTKIKSKVAIG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_LEGPA
Sequence: MARLKEFYKKDVVTMMMKRFNYSSVMEVPRILKITLNMGVGEAVGDKKVMNHAIEDMTLISGQKPVVTKARKSIAGFKIREGWPIGCKVTLRRERMYEFLDRLISITLPRVRDFRGLNPKSFDGTGNYSMGIHEQIVFPEIDYDKTDGIRGLDICITTSAKTNEEAKALLEAFNLPLKDKDRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: MSRA_SALNS
Sequence: MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPNPTYREVCSGQTGHAEAVRIVYDPAVISYEQLLQTFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQNAAAHASRERFQSAMTAAGDHRPITTEIAHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: DAPA_SODGM
Sequence: MFTGSIVALVTPMDEKGAIDRVSLKKLIDYHVASGTAAIVAVGTTGETSTLSHEEHGDVVMWTLELSDGRVPVIAGTGANSTSEAVSLTRRFNDSGVVGCLSVTPYYNRPSQEGLFQHFRAIAERSDLPQILYNVPARTGCDMLPPTVARLAEIKNIIGIKEATGNLSRVSQIQELVNDDFLLLSGDDASALDFIQLGGKGVISVTANVAAKEMAQLCALAADGNYADARRLNQRLMPLHQKLFFEPSPIPVKWACKALGLMATDTLRLPMTPLTRAGSRVVRQALTDAGLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_VIBVU
Sequence: MKKITINDLIKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGKNDTLPVTVEDIAYHTRCVRAGSPNCLLMADMPFMSYATPEQACENAAQLMRAGANMVKIEGGDWLVDTVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGRDQEKADRMVKDALALQAAGAQIVLLECVPAELAARITQVLDVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDMRKAVALYMEQVQAGTFPDEAHTIA
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_LEVBA
Sequence: MAYKHQIIERKWQHYWRANHTFETSDSQTKPKYYVMDMFPYPSGQGLHVGHPEGYTATDIMARLKRMQGFNVLHPMGWDAFGLPAEQYALKTGHNPKDFTAHNIKNFKRQIRSLGFSYDWSREINTTDESYYKWTQWIFEQLYKKGLAYEDKIMVNWAPDFMGGTVVANEEVIDGKTERGGYPVYRVPMRQWVLKITAYADRLIDDLDDLDWPDSIKEMQRNWIGRSEGASVFFPVDGQADTKIEVYTTRPDTLFGATYMVLAPEHAAVAKITTPEQADAVKAYQEAIESKSDLERTDLNKDKTGVFTGAYGINPLSGKKLPIWIGDYVLSSYGTGAIMAVPAHDERDHEFATKFNLPITQVIEGDADTDITEAAYTDDGKHINSDFMNGMDKQTAISAAIDWLTEHDAGHKQVNFRLRDWIFSRQRYWGEPIPVIHWENGETTLVPEDELPLKLPAAKQLEPSGTGESPLANLDDWVNVVDENGRKGKRETNTMPQWAGSSWYFLRYVDPTNDQAIADPEKLKYWMPVDLYIGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLVNQGMILGTNHEKMSKSKGNVINPDEIVEKHGADTLRLYEMFMGPLEASKPWSTEGINGSRRWLDRVWRLLIDDNNRLRDRVTMINDGALDKIYNQTVKTVTEDLEAMRFNVAISQLMVFVNEAYKVDSLPMIYMEGFVKLISPIVPHIAEELWSLLGHDETIAYAKWPTYDAKQLVEDVVELVVQVNGKVRAHLKVAKDATKDAIEAAALADETVQVHTDGKTVRKVIVVPGKLVNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDI54_ORYSJ
Sequence: MISSSKLKSVDFYRKIPRDLTEASLSGAGLSIVAALAMVFLFGMELSNYLAVNTSTSVIVDRSSDGEFLRIDFNLSFPALSCEFASVDVSDVLGTNRLNITKTVRKYSIDRNLVPTGSEFHPGPIPTVSKHGDDVEENHDDGSVPLSSRNFDSYSHQYPVLVVNFYAPWCYWSNRLKPSWEKTAKIMRERYDPEMDGRIILAKVDCTEEIDLCRRHHIQGYPSIRIFRKGSDLKENQGHHDHESYYGDRDTESLVAAMETYVANIPKDAHVLALEDKSNKTVDPAKRPAPLTSGCRIEGFVRVKKVPGSVVISARSGSHSFDPSQINVSHYVTQFSFGKRLSAKMFNELKRLTPYVGGHHDRLAGQSYIVKHGDVNANVTIEHYLQIVKTELVTLRSSKELKLVEEYEYTAHSSLVHSFYVPVVKFHFEPSPMQVLVTELPKSFSHFITNVCAIIGGVFTVAGILDSIFHNTLRLVKKVELGKNI
What is the function of this protein?
Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.  May play a role in storage protein biogenesis (By similarity).
What are the official names of this protein?
Protein disulfide isomerase-like 5-4, OsPDIL5-4, Protein disulfide isomerase-like 8-1, OsPDIL8-1.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IGE_HUMAN
Sequence: QVQLVQSGAEVRKPGASVRVSCKASGYTFIDSYVGWIRQAPGHGLEWIHWINPNSGGTNYAPRFQGRVTMTRDASFSTAYMDLRSLRSDDSAVFYCAKSDPFWSDYNFDYSSSEEGTEVTYTVSGAWTLPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTVDNKTFSVCSRDFTPPTVKILQSSCDGLGHFPPTIQLCLVSGYTPGTINITWLEDGQVMDVDLSTASTESQGELASTESQLTLSQKHWLSDRTYTCQVTYQGHTFQDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWQEKDEFICRAVHEAASPSQTVQRAVSVNPGK
What is the function of this protein?
Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin epsilon heavy chain, Immunoglobulin epsilon heavy chain ND.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: Y853_MYCBO
Sequence: MVRADRDRWDLATSVGATATMVAAQRALAADPRYALIDDPYAAPLVRAVGMDVYTRLVDWQIPVEGDSEFDPQRMATGMACRTRFFDQFFLDATHSGIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFKTATLSDLGAEPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLVYLPVEAQDALFDNITALSAPGSRLAFEFVPDTAIFADERWRNYHNRMSELGFDIDLNELVYHGQRGHVLDYLTRDGWQTSALTVTQLYEANGFAYPDDELATAFADLTYSSATLMR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mb0853.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: RL28_SYNWW
Sequence: MAKCDICGKGVGFGKKYSHSHIRTNRQWKPNIQPVKAIVDGTPKKIYVCTRCLRSGKVERAI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ECCA1_MYCSE
Sequence: MVNHLAGMFGSAVGMMSNSRARALEIFTEITNYDESACDAWVGRIGCGDTDRVTLFRAWYSRSNFGQLAGAAEISMNGVGARIPIGGIYSRDITYPINSPLAITMGFAVHEASEGNYTDAMEALEDAPAAGSEHLVSWVRAVIYGAGQRWTEVIDQVRGAERWPDKFLAAAAGVAHGVAAANLGLFTEADRRLTEANDTPVAQACAPVIAWYLAMARRSQGNEESAQVLLEWLQANFPEPKVTAALRDPAYRLETTTAEKIAARSDPWDPSSVVADTSARDKLLVEAQAELDRQIGLGRVKEQIEAYRAATQMARIRAARGMKVAQTSKHMIFAGPPGTGKTTIARVVANILAGLGVIAEPKLIETSRKDFVAEYEGQSAVKTSKTIDRALGGVLFIDEAYTLVQERNGQTDPFGAEALDTLLARMENDRDRLVVIIAGYSNDIDRLLEVNDGLRSRFATRIEFDSYSPDEIVEISKVIATANDSRLDDTAAKRVLEAATTLSQRSLNGKPALDIAGNGRYARQLVEAGEQNRDMRLARSLDFDSLGVDQLSEINGDDMAAAIASVHSRLNIGE
What is the function of this protein?
Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable).  Plays a role in DNA conjugation, in both donor and recipient strains (PubMed:18554329).  EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity).
What are the official names of this protein?
ESX-1 secretion system protein EccA1, ESX conserved component A1, Type VII secretion system protein EccA1, T7SS protein EccA1.
What is the protein family that this protein belongs to?
Belongs to the CbxX/CfxQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GET2_KLULA
Sequence: MATELSDAEKRKLLRERRQQKFSNGGASSRLNKITGQQQNSFLSSTSVLDEPKVTPSGNKKSSNVSDEEVEKSTKEIQDLLSSIPGNKDNSETDAAETNPEVALFQQLLKMQQQGGGFQNGSPDASTPDLFSSLLNNDTNTTASATQMLPNFVDEKVLKYYKFKVSKLKSYIILIKWALLAPYVYFIMHPNPTVLQASNLLSQIVERSNFFSIFTGLEIVFISIYYQMLKKLQRDNNVTATQNAGGILKYLTMIPEGILPIRNIQGKIGLALEYFDVASMYVTDICFVLVLFGVMKYYHSSFPISVPIEPPIAGIQ
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
What are the official names of this protein?
Golgi to ER traffic protein 2.
What is the protein family that this protein belongs to?
Belongs to the GET2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: MAB10_CAEEL
Sequence: MSSSSSSSLPTSSASTTTSSITSRPSASHHLESILSSSSSSPSILSSLTTQSTSSIPTSSSSSSQRQSTSNADRPVSPKPMPTPTTLSEWQLLAVLSKANLVQYYDVFIAQGGDDINQIMACEEREFLEIMNLVGMLPKPLHVRRMQRALAEYSQDQTAFNLAALQQIGPPPPLNYTPAGTDPMALLLPGIAAATSPKFPSLRFLSQLSSVAEKVSTPSEAADTSSSSPSLNLNTTSSNSVPLAFKFSTPLLESLASDQQSSSTSSVRSVLPSTSSNTSHPELPAGILPATTTNVSAAVPPPSSRATANVFSGNSIGLNFSGAASVTRHLVVPPSSTSIQQPSTSFGRSSSITGQEKEGSSSPFLGVGYSQPYGNDFVSLGDFDPNNPSLTENPTLSTAQISRLAECALAASKNLPPLPPRLVQNKKRVSKEVIELLKCSPATPSMIHAFRKYSAIYGRFDTKRKPHKVLTLHETTVNEAAAQLCLLVPSLLTRRDELFPLARQIVKDAGYNYAKSRKRPCDPADLHSPISSPGNSPPPQESEFDEQPSSSSGAFKEEERPPIPPEAWAAIIEKMKGELPES
What is the function of this protein?
Transcriptional cofactor (PubMed:21862562).  Heterochronic protein, involved in timing of a subset of differentiation events during the larval-to-adult transition (PubMed:21862562).  Promotes hypodermal terminal differentiation, together with transcription factor lin-29, perhaps as part of a transcriptional complex (PubMed:21862562).  Involved in regulating molting by repressing the expression of nuclear hormone receptors nhr-23 and nhr-25 in the adult hypoderm, probably acting in concert with lin-29 (PubMed:21862562).
What are the official names of this protein?
NAB transcription cofactor mab-10, Protein male abnormal 10.
What is the protein family that this protein belongs to?
Belongs to the NAB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: S35G2_CHICK
Sequence: MDSSSQKYLVKKRVKIHPNTVTVKYTSHYPQPGEEGYEDGNEDTGVFMEDSPKTRLLNAGKKRERTFFGTIDTQLQPAQLPKPREMGHFQNFPEGNILQSRKMWIVLFGSAVAHGCVALITRLISDRSKVPSLELIFIRSILQVLSVTAVCYYHEPPFGPKGYRLRLFFYGVCNVISITCAYTSFSIVPPSNGTIMWRATTTVFSAILAFLLVDEGMASVDIVTVVGSVFGVCLVMIPNIVKEENSLLSTWKEAFGYTMTVMAGLTTALSMIVYRSIKDNISMWTALFTFSWTGTVWGASTMFLLQEPIVPLDGETWSYLLAICLCSTAAFLGVYYALSKFHPALVSTVQHLEIVIAMVLQLVVLRILPGTYDLVGGAVILVSVVFLACHKLSWKNLGRQDYQEIVDSSIK
What are the official names of this protein?
Solute carrier family 35 member G2, Transmembrane protein 22.
What is the protein family that this protein belongs to?
Belongs to the SLC35G solute transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.