Protein: CPAS_ASPOZ
Sequence: MKTPIAVVGTACRFPGDISSPSQLWELLSNPKDVLRDLNPKRLNLTGFNHHNAEHHGATNVPNKSYILDDDVYRFDAAFFNISAAEAEAMDPQQRLLLETTYEALESAGYTLKQMRGSSTSVFIGAMTSDYHDIQARDLDTISRWHATGTSPSILSNRISYFFDLKGPSMTVNTACSSSLVALHQAVQSLRNGDCTAAIVGGVNLLLDPEVYISHSNLHMLSPTSRCRMWDRDADGYARGEGCTSIMIKTLDQALKDGDDVECIIRETAVNSDGRSAGITMPSPEAQATLIRETYERSGLDPVRDRCQYFECHGTGTQAGDPVEAQAIQQTFYPKNAVFSPDDKLYVGSIKTLIGHLEGCAGLAGVMKAIMCLKNRTITPNMFFDNLNPNISPFYDHLRIPTNTVPWPPVAHGCPLRASVNSFGFGGTNAHAIIESYVPSQPKRQASYCKESNRQKYTNSGPFVFSAHTQESLYSNIERTARYVRSNEALDLGHLAWTLAKRTVLPFKVAITALSREELLGNIDKAIVEYKASKASAQGPSPWKHPPEPHRIMGIFTGQGAQWAGMGRELLLASTVFRKSIERCEHALATLHDGPSWSLQEELLADKPSSRLSNPAISQPVTTAIEIAAYDLLCTSGVNVDVVVGHSSGEIVAAYALSIISAEDAMKIAYYRGLHTKPARSGRMLAVSLSFHDARELCSWPSFSGRVVVAASNGPASTTLSGDYDAILEVKALLDRKKTFARTLQVDVAYHSHHMVPCSAAYLESLRACNIQVKSPRSGCTWISSVTGRNAILDGDIQSFSATYWVDNMVKPVLFSQALDKSLCGTQDLGVCIEFGPHPALRGPVLDTLKSKGTSSVHYTSLLRRGQNDLNAASSAVGYLWERMADRVDLASFLQGFRSQALQLIKGLPGYSWDHGRRYWRESRISRRYRLEGTQLHPLLGRRSADEFPNEFCWKNMLHLKEMPWAQGYKEEGRVVLSAAFYLCSLLSAASSAAVCQRLVVLELNNFVVMEPITLEEYGNGVEYITTIRFDNEDFRTISSTILHAEASCHACKSDESVLTKVCTARLTLHLGDARGPDCDCLPPRGQRNDLLAPVDVADLYDSFEQAGMSYTGPFRSITSIQRSLGEATASVAWAVDTTMPESVLNPAMVEASFQAIMCAFASPLTEELRTPFHAKEIRRVLVTPRLALGGVSCDIDAFVTGVDCGGVEGDVSLYKPDGNAMIQIEGLVMKSVPQPDTSSDRNLFSHVVWESDPFGYSLISYPTPNEDMGWKRAADIVALYHLRRTVEEIDPLESAGFTPHHQLLYREISHIAAAGRGSEYYITHPDCAQTSEEIILAMIDKYAGIVDLQSLHSFGKALPAILRGELDLHNTPNEPDTLEGFTHDAAMFSQLSKDICSIVRRIVHKHPHMNVLGLDPGPSVITHQILEALDDKHTSYCLGSADPVILNKTLARLSAQHRNLYSKVIDLTTVNAGEHGSDKYDMVIAANPLHGTDTSANLFEVCRAMLKPGGYLVFVRVTGRVSMSLLCTCGWLPQWWQGYDQDARSWTDMSTVRYDSHLRSKGFSGIDHIFHDSMNSNGDGLSVMVTQAVNDTVMMLREPMNSTGLAPLTETVVFVGGKTLSVARLLQSIRRIVAASGTATTVVEDIDRLEMNGLTKQHSIISLVELDEPFFSRGAFHERLLAFKELVARSKHVLWLTTRNMTSISVAIGRAMRSERGADISLQFLGLSTVANISPSAVVEVFLRLTWSFVPVLTDGEVLWTNEPELQWDGSTLRIPRLVWDHKRNKRYNYRHRQGRPEAGLPQTAVPLSPRVSTNSVAVQIKYSCLVCTDVYLWVGARIDGQGNVVGISDHVSFVIHARLDHVHNLSDEHDLSPDALRATASFTLAYLLIKSLSGPILLYEPDELLAAAVEQDREPEQTVYFVTSKYNDCSRGWITVHPHASRRMVERMLPRKVSAFVDLSSSDDHVVTTLRDIYSHARIQAVELYRRAFAASPGQLIADSYTQACTSLSILSHTALEVTSSTEASTNIASVAYPKVVNWTSPAPIASPGDMISATTMFSSSGTYFMIDMATPLGLSILKWMATNGARKFVLAGRNPRMHEAWLEEMSRLGATVKPLKMDVSNKESILSAFTQIKEALPPIVGVCYAPLALSDQGFEYTVEDAGGLAATAMINAAKYLDELFPTPTLDFFVILTSLVSVIGTPKQVAYHAPSLFMTDLIQRRRLRGLVGSVMALGMVVDAGYFSRQGKEVIQRMMHHGYAPLSESDLHHAFGEVVAAGVPEAEGNAEIFFGLQLIDSQIDQSRESTSVSNHLLSHFITSRSGTKEGQYAEQEDSPSLLVPDEQLQESGPGRNKYDDLLARLSGKVRSILRLGDQALDVHTPLLDLGCDSLLAVDIQAWVAKEFDIDITPMDALLDTVAGLCEKAVPKPNAPGFVVEKEEQLVKELDFIDVATTASRSEHSSSVQDIPLDSTSSESSCVLCPSDSGFEQVRNDLEPRFTRIEKMSPHQSQIWFAGHWMRDPTQYNVVISYNVEGRFPVDRFKEALEHAVSMHESLRTAFFSDPNNGDLLQGVLKVPPPFLEHVRTPSAASVSQEFDKLASYQWRLEDGEVMRVTVVSIGKDQHTVIFGYHHIVMDGASWSTFLHDLKCIYEQRPRREVAQYVDYSLMLNRDIHNGTFAKELEFWKSELLPPPEMMPVLPLAKEKTRIPTDNFKVHTSTRHISIEATERIKQASRSLRGTPFHFYLATLQVFLAGLLKIESLCIGMSDANRKHQQFTGTVGYFLNMLPLRFEVQQTDSFANVFQKTSSKVLTALLNSSIPSNLVVDALNIPRVSNVTPLFQVAINYRVGEITRMSVDDFALNYDRSVMGNAPYDISFHVTPCANGTSIVEVNCRDYLYSPKATERIIDEYVRLLEIMSSNPLISVQSSVATSAPINEDGLSVQRGPRISHGWPATLPERFQDMVDQYGDRIAITDQGRDFSYLQLQAQSTRIGEALLQKGVRSGDTVAVLCPPSMNSVASMLAILRISAVYVPLDLSLPAARHKAMILASPVRALVCVSSTVEKVLELGVSTILNLSEIPDIRAPSTRFTNSAKGDSLAILLYTSGSTGQPKGVCLPQSGFINYLAAKRKELGLDSSTVVLQQSSLGFDMGLAQTLNAIMNGGKLVIVPQELRGDSIEIARIIRDQKVTFTLATPSEYLVMLQHGREYLHNYAGWRHACLGGEPFTDQLKREFVRLGKNCPVVQDSYGVTEISACTTFETMTASQLEEARSVGRTIPNTSLYIVDADCNLVATGEPGEICISGAGVALGYLNEEQTRLKFVQDPFALPDDIARGWTRVYRTGDKAKLLDDGSLILLGRMDGNTEVKVRGLRIDLEDVASTMVNCHPDLLSSAIVCVKGQGVSETLVAFVAMMPGQTASDVELQHLACNLPLPQYMRPSTVICLDELPRNANGKIDRKRIDAMPWTAPTTLSQSSKRLTLGEGELKLLWQVLLPGKHIQPESDFFLLGGNSTLLVRLQGAIRTSIGVSLTLREMYGASTLAQMALKVDARKAESPSMTINWLAETAIPQHILDRASSTSNLNLPKHCQGSGCQILLTGSTSFLGRVLVQLLLQVPEVERVHCIAVEKEQEHVPPTSDKVSLYYGSLLDPNLGLSTAEWASLQDRVDVVIHNGSNGHCLNTYNSLKGPNLGSTHRLAEFALQSQVPLHYISSGRVILQSGQTALGPTSVSFHPPPLDGSDGLTATKWAGEVFLERLAEHTDISISIHRPCTPIGDQAPAQDALNSLLRYSVNLGATPRLTRMEGYLDFQKVEIIAEEIATLVTSRFTKRSNTSSFTTRGVSFFHHSSNIKVPVKSFKEYMEKVHGRPFQELNLREWSSLALEQGIEPLIPSFLEAVDDNEETLRYPYLGN
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of the fungal neurotoxin cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca(2+)-ATPase with a unique pentacyclic indole tetramic acid scaffold (PubMed:18854220, PubMed:21608094, PubMed:19663400).  The hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) cpaS incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-terminal redox-incompetent reductase domain to make and release the tryptophan tetramic acid, cyclo-acetoacetyl-L-tryptophan (c-AATrp), as the first intermediate in the pathway.  CpaS catalyzes a Dieckmann-type cyclization on the N-acetoacetyl-Trp intermediate bound in thioester linkage to the phosphopantetheinyl arm of the T domain to form and release c-AATrp (PubMed:18854220, PubMed:21608094, PubMed:19663400).  CpaD then regiospecifically dimethylallylates c-AATrp to form beta-cyclopiazonic acid.  CpaD discriminates against free Trp but accepts tryptophan-containing thiohydantoins, diketopiperazines, and linear peptides as substrates for C4-prenylation and also acts as regiospecific O-dimethylallyltransferase (DMAT) on a tyrosine-derived tetramic acid (PubMed:19877600).  The beta-cyclopiazonate dehydrogenase cpaO then carries out the dehydrogenation of beta-CPA to yield an unstable enimine product, which is captured by intramolecular cyclization to create the pentacyclic fused scaffold of alpha-cyclopiazonate (PubMed:21608094).  Finally, the cytochrome P450 monooxygenase cpaH mediates the conversion of CPA into the less toxic 2-oxocyclopiazonic acid, the end product of the CPA pathway in A. oryza (PubMed:21608094).
What are the official names of this protein?
Cyclo-acetoacetyl-L-tryptophan synthase, Cyclopiazonic acid biosynthesis cluster protein A, Polyketide synthase-nonribosomal peptide synthetase cpaA, PKS-NRPS cpaA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.