Protein: PSPA_PENSO
Sequence: MLAQDVEFVDLPPPEATAGAATTDNETSSFNSNPVPTPSEASSIGPPHQLPVPVPDGDQPPLVEPMAICGMAMRLPGGIRDAEGFWDLLYNKRSGRCRVPKDRYNVENWFGPGKIGHVASEYGYFLDDVDLRNADASFWSMTKQEIEAMDPQQRLSLEVTYECLQNAGQRPEELRGRKIGVYLGTFEGDWLELDGRDPQHYHMYRLTGYGDYMSANRIHYEFGFMGPSVTIRTACSSSLTGLYDACHAISAGDCDSAIVACANIIYSPRTSITMQEQGVISPSGFCKTFDANADGYARGEAVSAVYVKKLSDAIRDGDPIRSVIRSTCINAGGKASTLTAPNTAAHETLIRRGHELAGVTDFSKTAMIECHGTGTAVGDPIETAAVANVFGEHGIYIGSVKTNLGHSEGASGLASIIKMTLALEHKIIPPNINFTTPNPKIPFERCKLKVPTEPLPWPKDRAELVGVNSFGIGGSNAHVLLGSAASFGIGSVQQKIIASEQSAEVAMTELTPRLLLFSAKHQQSLERMVANHQAYFLSHPESLDDMAYSLALKREELSHRSFCVTNGEDDWVPSRTHRTSGRAPPMLIFTFTGQGAQWAQMGKALIDQVPRFRRSIEKLDQVLQALPTPPRWKLIDEIRASKKKSRLSEAELSQPCCTAIQIALVDILEHYGIHPDAVIGHSSGEIGAAYASHAISGADAIQIAFYRGLVMCSLNPAERPGGMAAVGLGAEELTPYLRPGVRVGCENSPNSTTLTGDKVSLEETMKAIKEANPDVFVRALQVDRAYHSHHMETVAPEYVELLTNQRVQAMDPSVKFFSSVTGRQVDQSKELGPLYWAKNLVSPVRFSTAMEELVQSLIGPKVFLEIGPHSALAGPIRQILQHHKSTDEYFNTLTRGSDSHKDLLKAVGEMWLQNIPVNLTAVLGEGRFLPDLPLYPWHYEEPLWCESRLSKEWRLREFPHHDILGSRVLESTDQNPSWRNILRLDVVPWIKEHEVAGEIVFPGVGYICMAGEAIRQLTGETGFTARRVHIKAALVMHQGQDVEVITQLQRIPLTNAADSKWYNFTVHSYNKGIWVKHIFGQVCAGSDREHQAPSLESLPRQLSRRGWYRKMKEMGLEYGSRFMGLTDMTAHPIERKTIATVVNDIREGESKYAVHPVSLDCLLQAIVPATFNGLTRRFQHLGIPTYMEEIYVCPPLQPEMIIEACADEQPTAALSGSIIAVSNGHVTIDIRGLQMSAIGDAADASGQDPHAAVELEWREDINLISDAAKLIHPAKDRTDLHHLLDRFASASMMDTSTRLRGVEPTRSHLTHYQKWIESTADLIKLGKYPGLQPEDEIVEVSDAERVNIIESLYLSLLETDAAATATAIYRIWKECQGIFTGETDELELLLEGEVLHSLYDFMQNSEYRVFLELLAHRKPNLRVLEIGAGTGGTTATVLPALKSLYGERMYHSYTYTDISAGFFPQAKKRFENYPGLEFATLDISQDPLSQGFEAESFDLIIACNVLHATSTLQDTLTNVRRLLHPQGRLFLQELSPATKWINYVMGVLPGWWLGEQDGRYPEPYIGIDQWDALLSQSGFSGINLVSHDGYLNNNIVARPAADTQRQKRITLLHSCEDSASVTTSISQLLSSAGFGIDLYAIENANIPTPTQQDIVSILDLDRPFFHDLHESLFENLKGLLSQLRDTDSGILWVTRASQVGCKDPRYAMVNGVARVIRTELNIDFATLELEDFEQETLALIPQVLGEFQQRISEPNINTTTEWAVVGQKPLISRYHYIQVAEELKNNAVADSSTVKKLEQSRPGLVDTLCWKSMPISHALDENDVLVQVKCVGMNFKDVLISTGVITEKSSIGRGLGYEGSGLVLQVGSAVHKLSVGDRVIMSSSGSLTTTQQLDQRLCVKMPDSMTYEEGATMSAVYCTAIHCLLDVGGLRKGQSVLIHSASGGVGIAAMYIAQMVGAEVYATVGSEEKTQSLMSTFNIPRNRIFNSRTSEFLPRIMEETNGMGVDVVLNSLSGELLHASWKCTAEFGTFVEIGRRDFVGQGLLDMQPFEPNRSFVGFDLLLFSNKRPERIESIMTRAMDYYRAGFIQPIKPMTMFDAVSIVDAIRYMQRGQHIGKIVITMPENSTELSAEPPRQELALRQDRAYLFVGGLGGLGRSIATWLVEHGARHLVFLSRSAGNVPDDDPFVQELAVLGCTTTRISGDVSKLDDVLLAIRASGKPVGGVLQSSMVLRDNSFVDMNWDEWLGAVQPKVLGTWNLHNALLSEQPEEALDFFFLFSSAGAMSGQWGQANYNAGNTFLDAFVAYRHSLGLPASTVNIGVIQDIGYVSQNPEILDSLRSTAQYLMREPELLESIELMLHRSSPAESVVDHAVGRYVTRSQIGIGMRSTVPMDAPSNRTIWRKDPRMLVYRNLEVQSGPVSSSTGSDQVLTQFLREIGSNMTMLKAPETAELLAGEIGRTLFGFLMRADTEVVDLDAPLASVGIDSLISIELRNWIRRKIGVEVTVLEIVRADSVRDLGVLAQKKLAEK
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the alkylresorcinols called soppilines (PubMed:31086874).  The biosynthesis starts with the HR-PKS pspA-catalyzed carbon chain assembly through nine chain elongation cycles, using acetyl CoA and malonyl CoA as a starter and extender units, respectively, to produce the polyketide soppiline A (PubMed:31086874).  In the first round, the KR, DH, and CMeT domains work to produce 2-methyl-2-butenyl thioester (PubMed:31086874).  In rounds 2 to 5, the KR, DH, and ER domains fully catalyze the reduction of the elongated beta-ketothioester, resulting in the insertion of eight methylene units (PubMed:31086874).  The unusual Z,E,Z-triene motif is likely constructed during rounds 6 to 8 (PubMed:31086874).  Typically, the DH domain introduces a double bond at an alpha,beta-position of an elongated polyketide chain, with the dehydration of a beta-hydroxy group (PubMed:31086874).  The last extension cycle would be carried out with L-oriented beta-ketoreduction by the KR domain to produce beta-hydroxy carboxylic acid soppiline A (PubMed:31086874).  The type III PKS pspB intercepts the elongated polyketide chain at round 8 from the HR-PKS pspA, followed by a tri-keto extension and decarboxylative aldol cyclization to produce 1,3,5-trisubstituted alkylresorcinol soppiline B (PubMed:31086874).  Subsequently, the cytochrome P450 monooxygenase pspC catalyzes three-step oxidations at the C-4 methyl group to carboxylic acid to yield soppiline C (PubMed:31086874).
What are the official names of this protein?
Highly reducing polyketide synthase pspA, HR-PKS pspA, Soppiline biosynthesis cluster protein A.