PharMolix/UniProtQA huggingface dataset:
Protein: S22A1_RAT
Sequence: MPTVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGKSSST
What is the function of this protein?
Functional isoform capable of transporting TEA.
What are the official names of this protein?
Solute carrier family 22 member 1, Organic cation transporter 1, rOCT1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Protein: RIMO_GEOUR
Sequence: MSTSIKEKVSLVSLGCPKNLVDAEVMLGYLAKEKYEVTTDEREADIIIVNTCSFIKEAKQESIDTILDLADRKHDARCRLLIVTGCLPQRYQEELVKELPEVDIFVGTGDYPRIAEIIAEKEGMSEQLRYTGDPNFLYDEDLPRLQSSPYYTAYLKIAEGCSNCCSYCVIPSLRGAFRSRPLDKLLKEARELVARGVKEINLIAQDITGYGKDLAGGASLEGLIKELAALDGLQWIRLLYAYPDGISDSLIQLIRDEDKVCKYLDIPLQHVSDPVLKRMNRRSSEAEIRSLIAKLRGEIPGIALRTSLIVGFPGETDEDFKKLLHFVEETRFDRLGVFCYSREEGTPSAEMPDQVSERVKRERYKKLMRTQARVSFKHNRSLVDTEELVLIEGYSEETELLLKGRSSKQAPDIDGQVYVTSGNAQIGDIVKLRITDSSDYDLIGEIVP
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYG_HUMAN
Sequence: MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDKFKHLKSEDEMKASEDLKKHGATVLTALGGILKKKGHHEAEIKPLAQSHATKHKIPVKYLEFISECIIQVLQSKHPGDFGADAQGAMNKALELFRKDMASNYKELGFQG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CR1AB_BACTA
Sequence: MDNNPNINECIPYNCLSNPEVEVLGGERIETGYTPIDISLSLTQFLLSEFVPGAGFVLGLVDIIWGIFGPSQWDAFLVQIEQLINQRIEEFARNQAISRLEGLSNLYQIYAESFREWEADPTNPALREEMRIQFNDMNSALTTAIPLFAVQNYQVPLLSVYVQAANLHLSVLRDVSVFGQRWGFDAATINSRYNDLTRLIGNYTDHAVRWYNTGLERVWGPDSRDWIRYNQFRRELTLTVLDIVSLFPNYDSRTYPIRTVSQLTREIYTNPVLENFDGSFRGSAQGIEGSIRSPHLMDILNSITIYTDAHRGEYYWSGHQIMASPVGFSGPEFTFPLYGTMGNAAPQQRIVAQLGQGVYRTLSSTLYRRPFNIGINNQQLSVLDGTEFAYGTSSNLPSAVYRKSGTVDSLDEIPPQNNNVPPRQGFSHRLSHVSMFRSGFSNSSVSIIRAPMFSWIHRSAEFNNIIPSSQITQIPLTKSTNLGSGTSVVKGPGFTGGDILRRTSPGQISTLRVNITAPLSQRYRVRIRYASTTNLQFHTSIDGRPINQGNFSATMSSGSNLQSGSFRTVGFTTPFNFSNGSSVFTLSAHVFNSGNEVYIDRIEFVPAEVTFEAEYDLERAQKAVNELFTSSNQIGLKTDVTDYHIDQVSNLVECLSDEFCLDEKKELSEKVKHAKRLSDERNLLQDPNFRGINRQLDRGWRGSTDITIQGGDDVFKENYVTLLGTFDECYPTYLYQKIDESKLKAYTRYQLRGYIEDSQDLEIYLIRYNAKHETVNVPGTGSLWPLSAPSPIGKCAHHSHHFSLDIDVGCTDLNEDLGVWVIFKIKTQDGHARLGNLEFLEEKPLVGEALARVKRAEKKWRDKREKLEWETNIVYKEAKESVDALFVNSQYDRLQADTNIAMIHAADKRVHSIREAYLPELSVIPGVNAAIFEELEGRIFTAFSLYDARNVIKNGDFNNGLSCWNVKGHVDVEEQNNHRSVLVVPEWEAEVSQEVRVCPGRGYILRVTAYKEGYGEGCVTIHEIENNTDELKFSNCVEEEVYPNNTVTCNDYTATQEEYEGTYTSRNRGYDGAYESNSSVPADYASAYEEKAYTDGRRDNPCESNRGYGDYTPLPAGYVTKELEYFPETDKVWIEIGETEGTFIVDSVELLLMEE
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae.
What are the official names of this protein?
Pesticidal crystal protein Cry1Ab, 130 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryIA(b).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: SELA_SALA4
Sequence: MTSETRTLYSQLPAIDRLLHDSAFLSLRDRYGHTQVVDLLRRMLDDARDVIRNTQTLPDWYADWAQEAKLRLENAAQSALRPVINLTGTVLHTNLGRALQAQEAIEAVTQAMRAPVTLEYDLDGAGRGHRDRALATLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHAKDYRQAVNENTGLLMKVHTSNYSIEGFTKTVEEAELAEIGRELDIPVVADLGSGSLVDLSQYGLPKEPMPQQLIAAGVSLVSFSGDKLLGGPQAGIIVGKKAMIAQLQSHPLKRALRADKMTLAALEATLRLYLHPEALAEKLPTLRLLTRSEASIREQAQRLQARLAARYGDEFALEVKPCLSQIGSGSLPVDRLPSAAMTFTPHDGRGSRLEALAARWRTLPVPVIGRIYDGRLWLDMRCLEDESRFMEMMLK
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_VIBC3
Sequence: MELMVKGANALTVSETTFGREFNEALVHQVVVAYAAGARQGTRAQKTRSEVSGGGAKPWRQKGTGRARAGTIRSPIWRTGGVTFAAKPQDHSQKVNKKMYRGAMKSILSELVRQERLIVVENFSVEAPKTKALVAKLKELELNDVLIVTGEVDENLFLAARNLYKVDVRDVTGIDPVSLIAFDKVLMTAAAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MTA_CHAAC
Sequence: MDPCECSKSGNCNCGGSCTCTNCSCKSCKKSCCPCCPSGCTKCASGCVCIGKTCDTSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein A, MT-A.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: FRDD_ECOSM
Sequence: MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQSFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Fumarate reductase 13 kDa hydrophobic protein, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBIG_RICCK
Sequence: MSSIDKKELEKFEKISHNWWNKDGDFGILHCINPIRLEYIIEKITSHYNDISKLEILDVGCGGGLIATPLAAQGFNVTAIDALQSNIETATAYAKENGVKINYLQSTIEELKSNKLYDVVICLEVIEHVENVQQFILNLVQHIKPNGIAIISTINRMKKAYILGIIVAEYILGWVPKNTHNYSKFLKPSEIYEMLTDTGIEIKELKGLIYDMAKNEWKLSDNIEVNYFMYLERNTH
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: PCKG_MYCSM
Sequence: MTSATIPGLDTAPTKHQGLLAWVQEVAELTQPDRVVFADGSDEEYERLCAHLVEAGTFQKLNPEKQPNSYLALSDPSDVARVESRTFICTEREIDAGPTNNWMDPAEMRGIMTDLYRGSMRGRTLYVVPFCMGPLDAEDPKLGVEITDSEYVVVSMRTMTRMGRAALDKLGDDGFFVKALHSIGAPLEPGQKDVPWPCNDTKYITHFPETREIWSFGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYFIAAAFPSACGKTNLAMLQPTIEGWRAETVGDDIAWMRFGKDGRLYATNPEFGFFGVAPGTNWSSNPNAMKTIAAGNTVFTNVAKTDDGDVWWEGLEGDPQHLIDWKGNDWTPESGEKAAHPNSRYCTPISQCPTLAPEWDDPQGVPISAILFGGRRKTTVPLITEARDWQHGVFIGATLGSEQTAAAEGKVGTVRRDPMAMLPFLGYNVGDYFAHWINVGKNADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWAVERIEHKADGKSTPIGIVPTAADLDLEGLDVDPADVDEALAVKPEEWRAELPLIEEWFEFVGEKLPTGLKDEFDALKERLG
What is the function of this protein?
Involved in the gluconeogenesis, in growth on fatty acids and is important for initiation of infection in the macrophages.  Catalyzes the GTP-dependent conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.  It can also use IDP or ADP, but with a lower activity.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK, GTP-dependent phosphoenolpyruvate carboxykinase, GTP-PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPARG_RABIT
Sequence: MVDTEMPFWPTNFGIGSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDLPFARADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKTHEEPSNSLMAIECRVCSDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFVSLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPEASQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
What is the function of this protein?
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids.  Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase.  It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.  Key regulator of adipocyte differentiation and glucose homeostasis.  ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer.  Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses.  Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.
What are the official names of this protein?
Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation (By similarity).
Protein: TWF1_PONAB
Sequence: MSHRTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTDTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMGVIRKIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
What is the function of this protein?
Actin-binding protein involved in motile and morphological processes.  Inhibits actin polymerization, likely by sequestering G-actin.  By capping the barbed ends of filaments, it also regulates motility.  Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).
What are the official names of this protein?
Twinfilin-1.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).
Protein: ULAD_ECO81
Sequence: MSLPMLQVALDNQTMDSAYETTRLIAEEVDIIEVGTILCVGEGVRAVRDLKALYPHKIVLADAKIADAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDAGIGQVVYHRSRDAQAAGVAWGEADITAIKRLSDMGFKVTVTGGLALEDLPLFKGIPIHVFIAGRSIRDAASPVEAARQFKRSIAELWG
What is the function of this protein?
Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
3-keto-L-gulonate-6-phosphate decarboxylase UlaD, 3-dehydro-L-gulonate-6-phosphate decarboxylase, KGPDC, L-ascorbate utilization protein D.
What is the protein family that this protein belongs to?
Belongs to the HPS/KGPDC family. KGPDC subfamily.
Protein: DSBB_CUPNH
Sequence: MQANSRAYFLLIALVSFGLVGVALYLQFEKGYQPCPLCVMQRFAFIGIGIFSLLAAVAQNTRSLWQGLGMLSGIAGIAVAVYHVSLLLNPKASCGIDPLENWVNALPTAKALPQVFYADGLCTAPLPPVLGLSVPAWSLIWLFILTLTLAVGLIRREKNFR
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRHO_RUEPO
Sequence: MYTIAALYHFTRFADPADLKPALLDLCLAQGVKGTLLLAKEGINGTIAGPRAGIDAVLAHIRALPGCSDLEWKEATSDHPPFGKMKVRLKQEIVTMGQPDVDPRARVGHYVEPEDWNDLIRSDDVVLIDTRNDYEVAIGTFEGAIDPMTESFRDFPAWWEANKERFHNKRVAMFCTGGIRCEKSTNYLLGQGVEDVYHLKGGILRYLEEVPAENSTWQGECFVFDNRVSVGHGLVEGPHELCHGCRRPILPEDRNRPEYEHGVSCHLCIDETSEADKMRFRERQKQIALARARGEDHLATH
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: EX7S_ECO8A
Sequence: MPKKNEAPASFEKALSELEQIVTRLESGDLPLEEALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEDASLTPFTPDNE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_BUCAT
Sequence: MNFFIKSCFLDKEKTDCIVVSVFELSELSDSAIYLDKCSNGHITSLIKLGDIQGKIGDTLMLYKVPKILSKRILLVGCGKKDEINIIRFKKILKNTIHAIKKKSIKNIVYSFSNINIDNIYWMIRRMVLSLKESLYETIKINNTNIKNTNIHSITLNIIKKNDLFIAKTALKHALAIDHAITSTKNLSNLPPNICNPLYLSYKAQELSKKYENNIVVEIIDIKKMKELGMNAYIAVGNGSKNKPFMSVIKYSGNNIVNKKIIAFVGKGLTFDSGGISIKPALHMHEMKYDMCGAAAVYGTLIMAAELQLPLTVIGILSGCENMVGSHSFRPGDVLTTMSGQTVEILNTDAEGRLVLCDSLTYLERFSPDIVIDVATLTGACVTALGESVSGLFSNNEELSNQLLHASQETDDKIWSLPLFSEYHKELNSNIADFSNIGRGKAGAITAACFLSKFTKKYNWAHLDIAGTAWKSGKKSGATGRPVELLCQFLLNQSNYIYN
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACPS_SYNAS
Sequence: MVHGTGIDLVDIDRLEKILMKWDMSFLKKVFSPAEIEYCAKRAFPAIHYAARFAAKESFLKSLGMGIGMGIPLKDIEVRNDPLGRPVLNLYGKALEILEKRGITTVHVSLSHSRSQAGAVVILEGLKD
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZFPP_MYCTU
Sequence: MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPAFRHVDFLRALRDYSARHRSYGR
What is the function of this protein?
Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP).  Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall.
What are the official names of this protein?
(2Z,6E)-farnesyl diphosphate synthase, Short-chain Z-isoprenyl diphosphate synthase, Z-FPP synthase, Z-FPPS, Z-Polyprenyl diphosphate synthase, Z-isoprenyl diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family. Z-FPP synthase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: ENOB_BOVIN
Sequence: MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKSRYLGKGVLKAVEHINKTLGPALLEKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPELILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHISGEKLGELYKNFIKNYPVVSIEDPFDQDDWATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAVFAGRKFRNPKAK
What is the function of this protein?
Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate.  Appears to have a function in striated muscle development and regeneration.
What are the official names of this protein?
Beta-enolase, 2-phospho-D-glycerate hydro-lyase, Enolase 3, Muscle-specific enolase, MSE, Skeletal muscle enolase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity).
Protein: MSCL_CHLL2
Sequence: MLKEFREFVLRGNVADMAVGIIIGGAFGAIVNTLVSDVLMPPLGLLIGGIDFSNFYLVLKEGSAPGPYAALADAKAVGAVTVNYGIFLNALISFMIMAFAVFMLIKSLTSMRGKPEPPAPAPAVKECPYCCSTIPLKASRCPECTSQLEK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SDMT_PARMW
Sequence: MGTTNGCAADSVAATYYDSQDADQFYEQVWGGEDIHIGLYATPDEAIATASDRTVHALLDLADPLPQGGCVVDLGAGYGGASRRLARWSERPVHAINISAVENDRHRRLNVDAGLEQQITVHDASFEQVPMADASADLVWSQDAILHAGDRAKVLAEVSRLLKPGGCFVFTDPMAADGVEMGLLQPILDRIHLPDLASPSRYKAWGEAVGLTMEVWDERTEMLVRHYDRVRQDTRLRRAELETSISSGYLDRMDVGLGHWVDGGQQGRLSWGLMRLRKPG
What is the function of this protein?
Catalyzes the methylation of dimethylglycine to betaine with S-adenosylmethionine (AdoMet) acting as the methyl donor.  It has strict specificity for dimethylglycine as the methyl group acceptors.
What are the official names of this protein?
Dimethylglycine N-methyltransferase, Betaine synthesis N-methyltransferase B.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: LPXB_ECO81
Sequence: MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNGARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAAVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: CELF1_RAT
Sequence: MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINILRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRTMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLLQQTANSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY
What is the function of this protein?
RNA-binding protein implicated in the regulation of several post-transcriptional events.  Involved in pre-mRNA alternative splicing, mRNA translation and stability.  Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.  Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition.  Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs.  Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB.  Promotes exclusion of exon 11 of the INSR pre-mRNA.  Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast.  Increases translation and controls the choice of translation initiation codon of CEBPB mRNA.  Increases mRNA translation of CEBPB in aging liver.  Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3.  Mediates rapid cytoplasmic mRNA deadenylation.  Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation.  Required for completion of spermatogenesis.  Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs).  Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.  Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs.  Binds to the IR RNA.  Binds to the 5'-region of CDKN1A and CEBPB mRNAs.  Binds with the 5'-region of CEBPB mRNA in aging liver (By similarity).  May be a specific regulator of miRNA biogenesis.  Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (By similarity).
What are the official names of this protein?
CUGBP Elav-like family member 1, CELF-1, Bruno-like protein 2, CUG triplet repeat RNA-binding protein 1, CUG-BP1, CUG-BP- and ETR-3-like factor 1, RNA-binding protein BRUNOL-2.
What is the protein family that this protein belongs to?
Belongs to the CELF/BRUNOL family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
Protein: NQO11_PARDE
Sequence: MIGLTHYLVVGAILFVTGIFGIFVNRKNVIVILMSIELMLLAVNINFVAFSTHLGDLAGQVFTMFVLTVAAAEAAIGLAILVVFFRNRGTIAVEDVNVMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit 11, NADH dehydrogenase I, subunit 11, NDH-1, subunit 11.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.