PharMolix/UniProtQA huggingface dataset:
Protein: CMOA_DESPS
Sequence: MTDKKDTIFQNPGPAEDFEFNSRVVEVFDDMLDRSVPFYKEVIQASAQLLQRHLKENDSVYDLGSSTGTTLLELSRVLKRQDISYVGIDASKPMLEKARLKAELYSKGDQFSFLEEDITQFCHQEAGAVILHYTLQFIRPMQREEVMRRIYASLRPGGVLLLSEKTISHQKELNRDFISIYHHFKKDRGYSELEIAQKREALENVLIPFSQNENKNLLKKVGFECVESYFQWFNFSSFMAIKPQP
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: ARGC_GEODF
Sequence: MLKVAIVGASGYTGIELLRLLHGHPEVSVTCVTSEQSAGKNVAEIFPTLRSRYNLVLENLEPVRIAERADFIFTALPHKAAMEVVPTFLKLGKRVVDLSADYRLHDAREYAAWYEPHMNPELLKEAIYGLPELRREKIAEADLVANPGCYPTSIILGLAPLLKKKLVNPATIIADAKSGVSGAGRSAKVDNLYCEVNDGFKAYGVGGVHRHIPEIEQELSLLAGKQLTITFTPHLVPMDRGILSTIYAEPAGEVSLAGLVELYRDFYHGEAFVRVLPENNFPSTAFVRGSNFCDIGLTVDKRTGRIVIVSAIDNLIKGASGQAIQNMNIMNGFPENLGLESLGLFP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1433A_TOBAC
Sequence: MASPREENVYLAKLAEQAERYEEMVEFMEKVVGAGDDELTIEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEDHVASIKTYRSKIESELTSICNGILKLLDSKLIGTAATGDSKVFYLKMKGDYYRYLAEFKTGAERKEAAENTLSAYKSAQDIANGELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELGTLGEESYKDSTLIMQLFCDNLTLWTSDMQDDGTDEIKEPSKAEEQQ
What are the official names of this protein?
14-3-3-like protein A.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: CUL2_ARATH
Sequence: MAKKDSVLEAGWSVMEAGVAKLQKILEEVPDEPPFDPVQRMQLYTTVHNLCTQKPPNDYSQQIYDRYGGVYVDYNKQTVLPAIREKHGEYMLRELVKRWANQKILVRWLSHFFEYLDRFYTRRGSHPTLSAVGFISFRDLVYQELQSKAKDAVLALIHKEREGEQIDRALLKNVIDVYCGNGMGELVKYEEDFESFLLEDSASYYSRNASRWNQENSCPDYMIKAEESLRLEKERVTNYLHSTTEPKLVAKVQNELLVVVAKQLIENEHSGCRALLRDDKMDDLARMYRLYHPIPQGLDPVADLFKQHITVEGSALIKQATEAATDKAASTSGLKVQDQVLIRQLIDLHDKFMVYVDECFQKHSLFHKALKEAFEVFCNKTVAGVSSAEILATYCDNILKTGGGIEKLENEDLELTLEKVVKLLVYISDKDLFAEFFRKKQARRLLFDRNGNDYHERSLLTKFKELLGAQFTSKMEGMLTDMTLAKEHQTNFVEFLSVNKTKKLGMDFTVTVLTTGFWPSYKTTDLNLPIEMVNCVEAFKAYYGTKTNSRRLSWIYSLGTCQLAGKFDKKTIEIVVTTYQAAVLLLFNNTERLSYTEILEQLNLGHEDLARLLHSLSCLKYKILIKEPMSRNISNTDTFEFNSKFTDKMRRIRVPLPPMDERKKIVEDVDKDRRYAIDAALVRIMKSRKVLGHQQLVSECVEHLSKMFKPDIKMIKKRIEDLISRDYLERDTDNPNTFKYLA
What is the function of this protein?
Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes.  Involved in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Cullin-2, AtCUL1.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
Protein: BH133_ARATH
Sequence: MNRGVLESSPVQHLTAAGNPNWWNNVSRGLRPPTPLMSHEPPSTTAFIPSLLPNFFSSPTSSSSSSPSFPPPNSNPNFSSWLEMSDLPLDQPWSLSQLLLGGLMMGEEEKMEMMNHHHHQNQHQSYQAKRIQNWEEQVLRHQASMKQESSNNNSYGIMSSPNSPPNKSCATIINTNEDNNNNIHSGLNLSECNSSEMIGSSFANKKPKLQVPSSQSTLKVRKEKLGGRIASLHQLVSPFGKTDTASVLSEAIGYIRFLHSQIEALSLPYFGTPSRNNMMHQHAQRNMNGIFPEDPGQLVNEYCMKRGVSLSSTDNQKSNPNEEPMKDLRSRGLCLVPISCTLQVGSDNGADYWAPAFGTTLQ
What are the official names of this protein?
Transcription factor bHLH133, Basic helix-loop-helix protein 133, AtbHLH133, bHLH 133, bHLH transcription factor bHLH133.
What is the protein family that this protein belongs to?
Belongs to the bHLH protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GP149_MOUSE
Sequence: MSFFLSNLTNDSNLWKASHNSTETDLMNSPATLTLSLFCLICIMTLAALVGSIFSLVSLLTMQYRTVLSILVTSWSVDDLLSVLSVAIFMVLQWPKEAQGYFQSLCTTSALLYMCQGLSSNLKATLIVCYNFYTMNRTVESQSSSWRLGQVLGVTLTVWAVSLLLASLPLCGWGVFVRTPWGCLTDCSSPYVLLLFAVYASAFGLLAVLSVPLTHQLLCSEEPLRLHANYQEISRGASTPGTPAAAGRVLCLPPEDVEIPALRCTGGCSPSSDVVFAPGQPAASGAGAGRRENPGTPQGTNSFPLSLAQKRFSLILALTKVILWLPMMIHMVVKHVVGFQSLPVDMLSFLLSLLASSVTPVFVLSKRWAHLPCGCIINCQPDTYSVAFDGKKSKRKGFEFNLSFQQSYGLYKIPHADCYDDDENSISYHNPKNYECEATKEPWGDNRSVFNTITVEISTTPPLDSATLTGVHKCTNTDIPESKQAMKEEKGAFSVKTESDINYGETTSFEGPERRLSHEENQKPDLSDWEWCRSKSERTPRQRSGGGLAIPICAFQGTVSLQAPTGKTLSLSTYEVSAEGQKITPASKKIEVYRSKSVGHEPNSEESPSTFADTSVKIHLEVLEICDNDEALDTVSIISNISQSSTKVRSPSLRYSRKENRFVSCDLGETASYSLFLPTSDPDGDINISIPDTVEAHRQNSRRQHEERDGYQEEIQLLNKAYRKREAESKGD
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 149, G-protein coupled receptor PGR10.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL25_CHLAB
Sequence: MELVVTSRETDKKSLLKKIRQTGGIPAVIYSGGKSLANIVVDAHVFSKFLSSLESGALSSTIFSLSYEGRTIKALVKDIQYHVTSYRVIHLDFEELIEDRDVKLKIPIRCINAVDCVGVKLGGSLRQVIRALRVVCKPKDIVPYLELDVRSLGLSQTRKLSDIQIPAGLRPITPLKEVAVTVSRR
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: LEUC_STAA8
Sequence: MGQTLFDKVWNRHVLYGKLGEPQLLYIDLHLIHEVTSPQAFEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDEIANKQITTLQKNAIDFGVHIFDMGSDEQGIVHMVGPETGLTQPGKTIVCGDSHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLIKTYGVDFGTGYALEFTGETIKNLSMDGRMTICNMAIEGGAKYGIIQPDDITFEYVKGRPFADNFAKSVDKWRELYSDDDAIFDRVIELDVSTLEPQVTWGTNPEMGVNFSEPFPEINDINDQRAYDYMGLEPGQKAEDIDLGYVFLGSCTNARLSDLIEASHIVKGNKVHPNITAIVVPGSRTVKKEAEKLGLDTIFKNAGFEWREPGCSMCLGMNPDQVPEGVHCASTSNRNFEGRQGKGARTHLVSPAMAAAAAIHGKFVDVRKVVV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: GLNB_NOSP7
Sequence: MKKVEAIIRPFKLDEVKIALVNAGIVGMTVSEVRGFGRQKGQTERYRGSEYTVEFLQKLKVEIVVDDNQVDMVVDKIIAAARTGEIGDGKIFISPVEQVIRIRTGEKNTEAV
What is the function of this protein?
P-II indirectly controls the transcription of the GS gene (glnA).  P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA.  When P-II is phosphorylated, these events are reversed.  In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme (By similarity).
What are the official names of this protein?
Nitrogen regulatory protein P-II, PII signal transducing protein.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: COR1B_RAT
Sequence: MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFMVLPLNKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIITWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCTACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTAGFSRMSERQLALWDPENFEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPDAALEAEDWVSGQDADPILISLREAYVPSKQRDLKVSRRNVLSDSKPAGYSRSGVSTATAITDIPSGNLAGSGEAGKLEEVMHGLRALRVLVKEQGERISRLEEHLGRMENGDT
What is the function of this protein?
Regulates leading edge dynamics and cell motility in fibroblasts.  May be involved in cytokinesis and signal transduction (By similarity).
What are the official names of this protein?
Coronin-1B, Coronin-2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat coronin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.
Protein: U72E1_ARATH
Sequence: MKITKPHVAMFASPGMGHIIPVIELGKRLAGSHGFDVTIFVLETDAASAQSQFLNSPGCDAALVDIVGLPTPDISGLVDPSAFFGIKLLVMMRETIPTIRSKIEEMQHKPTALIVDLFGLDAIPLGGEFNMLTYIFIASNARFLAVALFFPTLDKDMEEEHIIKKQPMVMPGCEPVRFEDTLETFLDPNSQLYREFVPFGSVFPTCDGIIVNTWDDMEPKTLKSLQDPKLLGRIAGVPVYPIGPLSRPVDPSKTNHPVLDWLNKQPDESVLYISFGSGGSLSAKQLTELAWGLEMSQQRFVWVVRPPVDGSACSAYLSANSGKIRDGTPDYLPEGFVSRTHERGFMVSSWAPQAEILAHQAVGGFLTHCGWNSILESVVGGVPMIAWPLFAEQMMNATLLNEELGVAVRSKKLPSEGVITRAEIEALVRKIMVEEEGAEMRKKIKKLKETAAESLSCDGGVAHESLSRIADESEHLLERVRCMARGA
What is the function of this protein?
UDP-glycosyltransferase that glucosylates coniferyl aldehyde to form coniferyl aldehyde 4-O-glucoside (PubMed:15907484).  Glucosylates sinapyl aldehyde to form sinapyl aldehyde 4-O-glucoside (PubMed:15907484).  Is not active in presence of coniferyl alcohol or sinapyl alcohol (PubMed:15907484).  Can glucosylate the phytotoxic xenobiotic compound 2,4,5-trichlorophenol (TCP) (PubMed:15907484).
What are the official names of this protein?
UDP-glycosyltransferase 72E1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with SIS8 in the nucleus.
Protein: K1C27_HUMAN
Sequence: MSVRFSSTSRRLGSCGGTGSVRLSSGGAGFGAGNTCGVPGIGSGFSCAFGGSSSAGGYGGGLGGGSASCAAFTGNEHGLLSGNEKVTMQNLNDRLASYLENVRALEEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDELKNQIISATTSNAHVVLQNDNARLTADDFRLKFENELALHQSVEADINGLRRVLDELTLCRTDLEIQLETLSEELAYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISDDAGATTSARNELIEMKRTLQTLEIELQSLLATKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCLLIDGEDGSCSKSKGYGGPGNQTKDSSKTTIVKTVVEEIDPRGKVLSSRVHTVEEKSTKVNNKNEQRVSS
What is the function of this protein?
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
What are the official names of this protein?
Keratin, type I cytoskeletal 27, Cytokeratin-27, CK-27, Keratin-25C, K25C, Keratin-27, K27, Type I inner root sheath-specific keratin-K25irs3.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDH_DICDI
Sequence: MGLKNLIIRGRNYISDHLTKSSLEKAIIRRQKRGKVIENEKLIILGCGWGSYSFLKNLNSIKYDITVISPRNHFLFTPLLTSSAVGTLEFRSIAEPVRTTRDINEFKYIQASVTSINPENNSVLVKSTFHNEKPFEMKYDKLVIGVGSRNNTFGIKGVEENANFLKELHHAREIRQKIIECFERASLPDVSTEERERLLSFVIVGGGATGIEFTSELNDFFSEDLSRLFPFVPVNEVKIILLEASGKILSTFDQKLVKKALINFRNSGIDVRTHSSVKEVLKDYVILDNGDRIPYGLLVWSTGIGQHPLVKNSSFEKDSHDRIIVDDHLRVKNYSNVFSFGDCANVENKNYPPTAQVASQSAVYLAKEFNNLEKLNPNPPKPFAFKFLGLLAYTGKKSGILQTDFFDLSGFIGFITWRSAYLTRLGSLRSKIQVPFDWMRTLIFGRDISSF
What are the official names of this protein?
Probable NADH dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
Protein: HCAB_ECO5E
Sequence: MSDLHNESIFITGGGSGLGLALVERFIEEGAQVATLELSAAKVASLRQRFGEHILAVEGNVTCYADYQRAVDQILTRSGKLDCFIGNAGIWDHNASLVNTPAETLETGFHELFNVNVLGYLLGAKACAPALIAGEGSMIFTLSNAAWYPGGGGPLYTASKHAATGLIRQLAYELAPKVRVNGVGPCGMASDLRGPQALGQSETSIMQSLTPEKIAAILPLQFFPQPADFTGPYVMLASRRNNRALSGVMINADAGLAIRGIRHVAAGLDL
What is the function of this protein?
Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively.
What are the official names of this protein?
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase, 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase, 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase, CI-dihydrodiol dehydrogenase, Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase, PP-dihydrodiol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: IML2_YEAST
Sequence: MFRVFGSFGSKGNQSSGEEQSTKTKQVLKQANDFEIALKAMDFVLDDRTDEGLNLLKKAEMETGSDQTILTLARGVIEFLQATLSFETEEMKRAAITLGKAEQMSWKSKQNAEKTNFRSSSIYPPGTVYAVTYTESCLLHALLMLFSESMMEAAKALLKLRRAYTMLQDIMVTVKKAERSKNSSSPSPSEKSQESCGSFVSAETTFISVDIPYKLSSEDKSNPLLLEFAEKIYTMRMGRLSGAHIGNTPSFHRLRDDLGLQTTPSQASDRHSVSDDFDLEQATIDEFIHSGANLCYGILQVVLSLLPPAIGAVLSIVGFKGSREEGLRLVWKATKERNVHGCIGLLGLMFYYDGPFQFTDADFDIPPNDNGSRALNKSRTNDSSLLPGYMDSATLLHPGKILEDALLKARALFPNSALWLLNEAKMLAGKGRLRDSLALMDSIDVNSIRMRQVKSLMVFERAILLVNLHEYNRAADDLISLLDISDWSHALYTYFAGCCYLENWRMTQLGLLNDGKEQFYKERARELIFDAPSLLGKKTFKSKNLPLDRFMLRKVQQFNNMQKKLNLQEPLDSIATSPVHELAYFYNGYNRMTENDLILTKKMLTEYHNPAIDSEDPDQELIRNLLLSLTLRRLGDAERGLALLDDIVLPKIFYIQNGKVKYFKKTEDPWAYPAALYERALFCWKLGGMESLNECREWLLRAQNYAADYELSTRIGMKIKAALDRVENALA
What is the function of this protein?
Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins.  Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
What are the official names of this protein?
Inclusion body clearance protein IML2, Increased minichromosome loss protein 2.
What is the protein family that this protein belongs to?
Belongs to the IML2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized exclusively in cytoplasmic inclusion bodies under protein folding stress conditions.
Protein: Y2483_LEPBL
Sequence: MELNPGNPIFDYCVLPCFIFLARVTDVSIGTIRVILLTREKKVIAASLGFLEVLLWVIVITQVIKNLNNALCYLAYAGGFAAGTFIGMILEEKLAIGFSLLRIISPRNGDEIANKLSEAGYGVTTMNGQGSRGPVKIVFTVLKRKKIGQAMTIVKSVEPDVFYSIENARSTNTAVSEDSPGLLRIGILEKILKVRK
What are the official names of this protein?
UPF0316 protein LBL_2483.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STR7_STRTC
Sequence: MPLPTRKIGQSLVSEIGFGSMGIARLGPSGFYGVVESDDERFKVLDAAHAAGCTFWDSAHLYGDSEELIGKWLKRTGKRNDIFLATKFGITPQGVRGDPDFVKEQCATSLERLGVDCIDLFYQHRVDPKTPIEITVGAMAELVKEGKVKYLGLSECSAKALRRAHAVHPIAALQIEYSPFVLDIEDPKIALLETARELGVTIVAYSPLGRGLLTGQYKSPDDFEPNDFRRTIPKFSADNFPKILDVVAQLKKIGEKHNATPGQVTLAWILAQGPEFIVIPGTKKIKYLEENVGAASIKLTEEEVAAVRKLAEESEIPGDRNARMGAMLIDSPELPQ
What is the function of this protein?
Aldo-keto reductase; part of the gene cluster that mediates the biosynthesis of strobilurin A, an antifungal polyketide that contains a key beta-methoxyacrylate toxophore that targets the complex III of the mitochondrial electron transport chain (PubMed:30258052).  Strobilurin biosynthesis begins with construction of benzoyl CoA by step-wise elimination of ammonia from phenylalanine by the phenylalanine ammonia-lyase str11, oxygenation by str8 and retro-Claisen reaction to form benzoic acid, which is activated to its CoA thiolester benzoyl CoA by the dedicated CoA ligase str10 (PubMed:30258052).  Benzoyl CoA forms the starter unit for the highly reducing polyketide synthase stpks1 that produces the polyketide prestrobilutin A (PubMed:30258052).  The FAD-dependent oxygenase str9 then catalyzes the key oxidative rearrangement responsible for the creation of the beta-methoxyacrylate toxophore (PubMed:30258052).  Str9 performs epoxidation of the 2,3 olefin of prestrobilutin A, followed by Meinwald rearrangement to furnish the aldehyde intermediate (Probable).  Rapid enolization of the aldehyde intermediate would give the beta-methoxyacrylate skeleton and methylations catalyzed by str2 and str3 complete the synthesis and lead to the production of strobilurin A (Probable).  The short-chain dehydrogenase stl2 and the dehydrogenase str4 play a role in the shunt pathway leading to the production of bolineol (PubMed:30258052).  The cluster encodes no obvious halogenase gene that could be involved in production of strobilurin B, nor any obvious dimethylallyl-transferase that could be involved in the production of strobilurin G (Probable).  It is possible that unknown proteins encoded in, or near, the cluster (such as str1 or stl1) may form new classes of halogenases or dimethylally-transferases, or that the responsible genes are located elsewhere on the genome (Probable).  Similarly, proteins encoded by str5/str6 hydrolases appear to have no chemical role in the biosynthesis of strobilurin A (Probable).  Finally, no obvious self-resistance gene is found within the cluster (Probable).
What are the official names of this protein?
Aldo-keto reductase str7, Strobilurin A biosynthesis cluster protein r7.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Protein: COA8_HUMAN
Sequence: MLPCAAGARGRGAMVVLRAGKKTFLPPLCRAFACRGCQLAPERGAERRDTAPSGVSRFCPPRKSCHDWIGPPDKYSNLRPVHFYIPENESPLEQKLRKLRQETQEWNQQFWANQNLTFSKEKEEFIHSRLKTKGLGLRTESGQKATLNAEEMADFYKEFLSKNFQKHMYYNRDWYKRNFAITFFMGKVALERIWNKLKQKQKKRSN
What is the function of this protein?
Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 8, COA8, Apoptogenic protein 1, mitochondrial, APOP-1.
What is the protein family that this protein belongs to?
Belongs to the COA8 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: Y3341_YERPG
Sequence: MNLQHHFLIAMPSLQDPQFKRSVIYICEHGEKGAMGLVINKPLEQLTVETILEKLKIKSPSRDPAIRLDNVVLAGGPLAEDRGFILHSPQEGFASSIHISPETMITTSKDVLETLGTSGQPKNLLVALGYASWRQGQLEQELLDNVWLTTEADTHILFNTPIAERWQAAANKLGINIFNIAPQAGHA
What are the official names of this protein?
UPF0301 protein YpAngola_A3341.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: GAR1_XENTR
Sequence: MSFRGRGGFNRGGGGGRGGGGFGGRGGGRGGYGQGGGRGGFGRGGGRGGFNRGGYDQGPPESVVEVGEFMHPCEDDVVCKCITQENRVPYFNAPIYLENKEQIGKVDEIFGQLRDFYFSIKLSENMKASSFKKLQKFYIDPAKLLPLQRFLPRPPGEKGPPRGGGRGGGRGGGRGRGGGRGGGGGFRGGRGGGFGGGGGFRGSRGGGFRGGRGFRGGR
What is the function of this protein?
Required for ribosome biogenesis.  Part of a complex which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit 1, Nucleolar protein family A member 1, snoRNP protein GAR1.
What is the protein family that this protein belongs to?
Belongs to the GAR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: UREG_ACTP2
Sequence: MRKYIKIGVAGPVGAGKTALIERLTREIASKYSVAVITNDIYTQEDAEFLTKNSLLPPERIMGVETGGCPHTAIREDASMNLEAVDEMVARFPEVELIFIESGGDNLSATFSPDLADVTIFVIDVAQGEKIPRKGGPGITRSDLLVINKTDLAPFVGADLSVMERDARRMRNGQPFIFTNLMKNENLDGVIGWIEKYALLKNIEDPASLVR
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_TROWT
Sequence: MRLIKLHHLRPAPGSRRARVRVGRGEGSKGKTAGRGTKGTKARAPVRPGFAGGQIPLHMSIPKLKGFKNHKKVEYSVISIKRLCEAYPSGGVVTRDNVMSVIGKKRGFVKLLSDGEVTVKFDITVDKASAAAVEKITSAAGTVTQAR
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: FOXH1_MOUSE
Sequence: MASGWDLASTYTPTTPSPQLALAPAQGYLPCMGPRDNSQLRPPEAESLSKTPKRRKKRYLRHDKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFHKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPYQPPSPPPPPREGFSIKSLLGDPGKESTWPQHPGLPGQSTAAQAGTLSKGEEGMGTGPSSSSETPLWPLCSLPGPTIIEGESSQGEVIRPSPVTPDQGSWPLHLLEDSADSRGVPRRGSRASLWGQLPTSYLPIYTPNVVMPLATLPTTSCPQCPSSASPAYWSVGTESQGSQDLLCDLDSLFQGVPPNKSIYDVWVSHPRDLAAPAPGWLLSWYSM
What is the function of this protein?
Transcriptional activator.  Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'.  Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling.  Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
What are the official names of this protein?
Forkhead box protein H1, Forkhead activin signal transducer 1, Fast-1, Forkhead activin signal transducer 2, Fast-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: S52A3_HUMAN
Sequence: MAFLMHLLVCVFGMGSWVTINGLWVELPLLVMELPEGWYLPSYLTVVIQLANIGPLLVTLLHHFRPSCLSEVPIIFTLLGVGTVTCIIFAFLWNMTSWVLDGHHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISDSVPSPVPTRETDIAQGVPRALVSALPGMEAPLSHLESRYLPAHFSPLVFFLLLSIMMACCLVAFFVLQRQPRCWEASVEDLLNDQVTLHSIRPREENDLGPAGTVDSSQGQGYLEEKAAPCCPAHLAFIYTLVAFVNALTNGMLPSVQTYSCLSYGPVAYHLAATLSIVANPLASLVSMFLPNRSLLFLGVLSVLGTCFGGYNMAMAVMSPCPLLQGHWGGEVLIVASWVLFSGCLSYVKVMLGVVLRDLSRSALLWCGAAVQLGSLLGALLMFPLVNVLRLFSSADFCNLHCPA
What is the function of this protein?
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22273710, PubMed:24264046, PubMed:27702554).  Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145).
What are the official names of this protein?
Solute carrier family 52, riboflavin transporter, member 3, Riboflavin transporter 2, hRFT2.
What is the protein family that this protein belongs to?
Belongs to the riboflavin transporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell membrane. SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi- pass membrane protein. Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: ILA1_CAEEL
Sequence: MKTYSFFVLFIVFIFFISSSKSHSKKHVRFLCATKAVKHIRKVCPDMCLTGEEVEVNEFCKMGYSDSQIKYICCPE
What are the official names of this protein?
Probable insulin-like peptide alpha-type 1.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: QUEE_BURM1
Sequence: MTYAVKEIFYTLQGEGANAGRPAVFCRFAGCNLWSGREEDRAQAVCRFCDTDFVGTDGENGGKFKDADALVATIAGLWPAGEAHRFVVCTGGEPMLQLDQPLVDALHAAGFGIAIETNGSLPVLESIDWICVSPKADAPLVVTKGNELKVVIPQDNQRLADYAKLDFEYFLVQPMDGPSRDLNTKLAIDWCKRHPQWRLSMQTHKYLNIP
What is the function of this protein?
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
What are the official names of this protein?
7-carboxy-7-deazaguanine synthase, CDG synthase, Queuosine biosynthesis protein QueE.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.