PharMolix/UniProtQA huggingface dataset:
Protein: NLRP3_HUMAN
Sequence: MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW
What is the function of this protein?
Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity).  During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity).  Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity).  May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity).
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, Cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Inflammasome. Endoplasmic reticulum. Secreted. Nucleus. Note=In macrophages, under resting conditions, mainly located in the cytosol, on the endoplasmic reticulum. After stimulation with inducers of the NLRP3 inflammasome, mitochondria redistribute in the vicinity of the endoplasmic reticulum in the perinuclear region, which results in colocalization of NLRP3 on the endoplasmic reticulum and PYCARD on mitochondria, allowing the activation of inflammasome assembly. After the induction of pyroptosis, inflammasome specks are released into the extracellular space where they can further promote IL1B processing and where they can be engulfed by macrophages. Phagocytosis induces lysosomal damage and inflammasome activation in the recipient cells (PubMed:24952504). In the Th2 subset of CD4(+) helper T-cells, mainly located in the nucleus. Nuclear localization depends upon KPNA2. In the Th1 subset of CD4(+) helper T- cells, mainly cytoplasmic (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane. Note=(Microbial infection) Upon HRSV infection, the protein is mainly located in lipid rafts in the Golgi membrane.
Protein: QNR_VIBPA
Sequence: MLKTDLIFERENFSHHDFQNATFKNCHFYMCSFDHADLRDAKFIDCRFIESKALEGCSFRFANLKDASFTNCMLAMSLFNGANCMGLELRKCDLKGANFQGANFANRVSNTMFFCSAFITGCNLTYCNFERVLLEKCDLFENRWNGANLAGATLKGSDLSRCEFSPEQWGTFNVEQCDLTHVELDGLDIRRVSLFGVKICDWQQEQLLAPFGLIIL
What is the function of this protein?
Has no effect when overexpressed in E. coli.  When Cys-115 is mutated to Tyr and overexpressed it increases (fluoro)quinolone resistance in E. coli up to 16-fold for ciprofloxacin, levofloxacin and nalidixic acid.
What are the official names of this protein?
Pentapeptide repeat protein VPA0095.
What is the protein family that this protein belongs to?
Belongs to the pentapeptide repeat protein family.
Protein: DAPD_AFIC5
Sequence: MSLSALETTLNTAFDARDSITAATKGEVRDAVELALDLLDKGEARVAEPQADGAWKINQWLKKAVLISFRLNDMAPIPGGPGGAQWWDKVPSKLENYSEQKFREAGFRAVPGAIVRRSAFIAKNVVLMPSFVNLGAYVDEATMIDTWSTVGSCAQIGKHVHISGGVGIGGVLEPLQAGPVIIEDNCFIGARSEVAEGVIVRKGAVLSMGVFIGASTRIIDRATGEVYIGEVPAYSVVVPGSMPGKPLPDGSPGPSLYCAVIVKRVDEKTRSKTSINELLRE
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLK_STRCT
Sequence: MKDGMRVGERFTHDFVVPPHKTVRHLYPESPEFAEFPEVFATGFMVGLMEWACVRAMAPYLEPGEGSLGTAICVTHTAATPPGLTVTVTAELRSVEGRRLSWRVSAHDGVDEIGSGTHERAVIHLEKFNAKVRQKTPAG
What is the function of this protein?
Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance.  Cannot use acetyl-CoA as substrate.
What are the official names of this protein?
Fluoroacetyl-CoA thioesterase.
Protein: VE6_MNPVA
Sequence: MDRTVHSFVERLGIPREDLLLPCTFCSRFLTQEELTAFDFSAFNLVWRGRCAHGICTACARVCASLDLFLHHQNSRPLADVLRDENLTLHGLKARCRVCMKILSVTEKLECAERGESFAKVRGQWRARCRICKPV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity.  Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1.  May also inhibit host immune response.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: CLPX_BARBK
Sequence: MSKVSNSGSEPKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSGIKTRDGVPTPQEIIEVLDDYVIGQRYAKRVLSVAVHNHYKRLAHQSKNNAIELAKSNILLVGPTGCGKTYLAQTLARIIDVPFTMADATTLTEAGYVGEDVENIILKLLQSADYNVERAQRGIVYIDEVDKISRKADNPSITRDVSGEGVQQALLKIMEGTIASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLERIISGRGEKTSIGFSATIKAPDERRVGEIFHDLEPEDLVKFGLIPEFIGRLPIIATLEDLDIDALVRILSQPKNALVKQYQHLFEMENVELTFHEDALRAIANKAIERKTGARGLRSIMEKILLDTMFELPALEGVQKVVISSDVVEGKARPLYIYSERVEDKENVSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL23_PROMH
Sequence: MIREERLLKVLRAPHVSEKASIAMEKSNTIVLKVAKDATKAEIKAAVQKLFEVEVESVNTLLMKGKVKRHGQRIGRRSDWKKAYVTLKEGQNLDFVGGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: VWCE_HUMAN
Sequence: MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM
What is the function of this protein?
May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
What are the official names of this protein?
von Willebrand factor C and EGF domain-containing protein, HBV X protein up-regulated gene 11 protein, HBxAg up-regulated gene 11 protein.
What are the subcellular locations of this protein?
Secreted. Note=According to PubMed:16496348 is localized in the cytoplasm.
Protein: RS12_TRIV2
Sequence: MPTIQQLIRTEREKARQKTKSPALKQCPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGTLDTAGVKDRKQGRSKYGTKRPKEAKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: VF84_ASFP4
Sequence: MPYARDITKFITATEPEVGLPLLALQRSKSIIGVILLVISLLFIFIGIIILSVSSYTTTGSIFVVLSLILGGGGFFLIYKDNS
What are the official names of this protein?
Transmembrane protein EP84R, pEP84R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus EP84R family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: GATB_RHOOB
Sequence: MTAVDTPDLLDYDEVLAKYEPVLGMEVHVELGTNTKMFCPCPTEFGAEPNTQVCPVCLGLPGSLPVVNEAAVESAIRIGLALNCSITPWGRFARKNYFYPDQPKNYQISQYDEPIATDGYLDVVLDDGTTWRVEIERAHMEEDTGKSLHVGGATGRIHGASHSLLDYNRAGVPLVEIVTKTISGAGARAPEVARAYVTALRDLLKSLNVSDVRMDQGSMRCDANASLMPIGATELGTRTETKNVNSLKSVEVAVRYEMRRQAAVLEAGGEVIQETRHFQEADGTTSPGRRKETAEDYRYFPEPDLEPVAPSAEWVEELRGTLPELPWVRRARIQADWGVSDEVMRDLVNANALDLVIATVEAGASPEAARSWWVSYLAQQANTRGVELGELPITPAQVAQVVALIDSGKLNNKVARQVVDHVLAGEGDPEQVVADHPELVVERDDTKLKAAVDEALAANPDIAEKIRGGKVAAAGKIVGDVMKATRGQADPARVKELVIEACGG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: MRAY_CERS1
Sequence: MLYLLTAFSDGGDIFNLFRYLTFRAGAAFFTALIFGFLFGRPLIDFLRRKQGKGQPIRDDGPTTHFAKAGTPTMGGLLILSALVVSTLLWARLDNPYVWIVLLVTVAFGLIGFADDYAKVKKQNTKGVPGRVRFLIGLLIAALAAIAAAWSHPPDLTLQLAMPFFKDALINLGWFFVPFAMVVIVGAANAVNLTDGLDGLAIMPVMIAGTTLGVIAYVVGNFNLTDYLGVHFVPGTGELLIFSSALVGGGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAVCTKHEIVLAIVGGLFVTEALSVIIQVLYFKRTGRRVFLMAPIHHHFEKKGWAEPQIVIRFWIISLILALIGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KDSB_SALNS
Sequence: MSFVVIIPARFSSTRLPGKPLVDINGKPMIVHVLERARESGAERIIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCGFSDDTVIVNVQGDEPMIPAVIIRQVAENLAQRQVGMATLAVPIHSAEEAFNPNAVKVVLDAEGYALYFSRATIPWDRDRFAKSLETVGDTCLRHLGIYGYRAGFIRRYVSWQPSPLEHIEMLEQLRVLWYGEKIHVAVAKAVPGTGVDTADDLERVRAEMR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSGG_SALTI
Sequence: MPRLLILVAVLLLSGCLTAPPKQAAKPTLMPRAQSYKDLTHLPAPTGKIFVSVYNIQDETGQFKPYPASNFSTAVPQSATAMLVTALKDSRWFIPLERQGLQNLLNERKIIRAAQENGTVAMNNRIPLQSLTAANIMVEGSIIGYESNVKSGGVGARYFGIGADTQYQLDQIAVNLRVVNVSTGEILSSVNTSKTILSYEVQAGVFRFIDYQRLLEGEIGYTSNEPVMLCLMSAIETGVIFLINDGIDRGLWDLQNKADRQNDILVKYRELSVPPES
What is the function of this protein?
May be involved in the biogenesis of curli organelles.
What are the official names of this protein?
Curli production assembly/transport component CsgG.
What is the protein family that this protein belongs to?
Belongs to the CsgG family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PG181_VACCA
Sequence: MDGVIVYCLNALVKHGEEINHIKNDFMIKPCCEKVKNVHIGGQSKNNTVIADLPYMDNAVSDVCNSLYKKNVSRISRFANLIKIDDDDKTPTGVYNYFKPKDAIPVIISIGKDRDVCELLISSDKACACIELNSYKVAILPMDVSFFTKGNASLIILLFDFSIDAAPLLRSVTDNNVIISRHQRLHDELPSSNWFKFYISIKSDYCSILYMVVDGSVMHAIADNRTYANISKNILDNTTINDECRCCYFEPQIRILDRDEMLNGSSCDMNRHCIMMNLPDVGEFGSSMLGKYEPDMIKIALSVAGIWKVL
What are the official names of this protein?
Protein OPG181.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG181 family.
Protein: PYRH_VIBC3
Sequence: MTTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDDYSWSDAIRELRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVANPDAQLYDKLAYNDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLISDVQ
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATRR_ASPFU
Sequence: MDGIGDGTESMGFDMPMLMNQQPHLFGSYGHDGSPVAPIFSNPTFQDEPSIGAADDNSDAKRRRIARACDMCRKKKIKCDGKMPKCSHCTNYKTDCVFTQVEKKRNPPKGAKYIEGLENRLGRMESLLRLSGLLSEDDGGKTDLGTLEKRLADRYHASGSNTPHNPQKINIPSQSQIAMSQQNSSSHYSTPRLESQSSPRTAATSPESQKESETEVEGLSDMMCSLVTNNCGETRYIGSSSGFSIFSPKGIQWVNEKTGDNSFQEMISSAYVDDNKWMYWKPEIFSDIFARRVFKPLPPKDEAMSLFKDFFDNFNCMFPLYHEPTFMHLVERQYSRDPYEGSGWWASINVVLAIAHRLRVMSNLVPQEEDRKAWLYLKNAMGVLTELTMRNTDLLSVQALLGMSLFLQGTPNPQPSFFLVAAAIRLSHSIGLHKRGSGFGLNPVEVEQRKRVFWIAYLLDKDICLRSGRPPVQDDDDMNVELPSDDPPDNIGNVPLSDGRSKFNLFRSMCRFATIESKVYKRLYSAKASKQSDGELLNTIGELDKELEDWKDSIPLDFRPEHEIKASHTPLILHVVVLHFAYYNCLTTIHRMSVHHGYWTSRLSNYAIQGLNARPLNPRVFLSAVLCVTAARASINLIKYIPQGDFACVWLILYYPVSALVTLFANILQNPSDARARSDVKLMNVVVNFLSTLVSDESNGSIKRMLGLCGEFERIAKVVLDKAEKESYSKKKRKSPEEPVNLQQSTPEEHPAPSPSTTQPTQAPSRNVPMSSPLFAENPGDPGGNTMADDAGGFASSREIPGTTGVSTNIPPNIQAMPGIAQDYQDMLSPDPLEGVSFADQPPYSATANTPLSSFQQPFVPQDLWQMPMTIEWDWADMSTNFPVFDTNGPPHGGL
What is the function of this protein?
Transcription factor that regulates expression of the genes related to ergosterol biosynthesis, including erg3B, erg24A, erg25A, as well as cyp51A that encodes a target protein of azoles (PubMed:30862750, PubMed:28052140).  Responsible for the expression of the ABC transporter abcC/cdr1B/abcG1 related to azole resistance (PubMed:28052140, PubMed:30862750).  Directly binds both the cyp51A and abcC/cdr1B/abcG1 promoters at a conserved 34 bp region called the atrR response element (ATRE) (PubMed:30862750, PubMed:28052140).  AtrR also binds to the promoter regions of both the sterol response transcription factor srbA and atrR genes themselves, the latter suggesting the possibility that atrR is autoregulated (PubMed:30862750).  AtrR is necessary for hypoxia adaptation and virulence (PubMed:28052140).
What are the official names of this protein?
ABC-transporter-regulating transcription factor.
What are the subcellular locations of this protein?
Nucleus. Membrane; Single-pass membrane protein.
Protein: RMP_DICDI
Sequence: MSSQEIFKKYEQKVVEYQDHIEELKSTKNDYKQLIDTLQHLPDTLQPKIMVPMGKLAFFEGNLKNTNEILILLGDNYFAKRSSKQTIDIIQRRDKDIDTSINDLREQIKGLKQRVSMTTDLSKALHEKEYDNIVEIKEEYNSDEEREKEKKRKQKPQKSTTTTTTTTTSKDKPKTEEEKKKSKEMDEEFDKMLKRLSILEEKENKMGDDYDEEEFNKKFNKKLDITGSDEEYDDDNYNNNNDDDDDNDEDDDREYYQEEGFEDEKPENSNYNKNIEEDDHDDDDDYYDEGEEIVEYYDENGNIVDINDPNVEYIQGDDDNDDNDNEEDEVDVELNESELEEIKDFHMDKKGQDLSEKEVKELTDFYHSKQKKRISYIDTPQPPTPEATTSITPKSILKTNSSGNLMSTIPKSYNENDENDIRRYIKNLDKQEKFENQKTISVPNPPKDVAFSGDIVEKETDLFPFDEIPKPTPPSNAKQSRFKSSRQNK
What are the official names of this protein?
RNA polymerase II subunit 5-mediating protein homolog, RPB5-mediating protein homolog.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase II subunit 5-mediating protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SUCC_CHLTR
Sequence: MHLHEYQAKDLLTAYQLPIPPYHVATSVPEVETAIQAEQWKAGVVKAQVHAGGRGKNGGVVIAHSPEDLLAAADKLLHMQFSSNQTAGLSLPINKVLISPLVEIASEYYLAIVIDRKHRCPVIMLSKAGGVDIEEVAEKQPDQLLKMTLPSSGKIYGYQLRRIAKFMEWDQPIADQGNRIIRQLLQCFYEKDASLLEINPLVLTKDGSLVILDAKMTIDDNALYRHPQLADCYDPSQENIRDVLAKQLGLSYIALDGTIGCLVNGAGLAMSTLDILKLYGGSAANFLDVGGSASEKQIQEAISLVLSDKSVRVLFIHIFGGIMDCAVVASGLVSAMQGQKETIPTVIRLEGTNVDKGKDMIINAGIPCEFVTSMSEGAELAVQLSR
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: PYREL_METLZ
Sequence: MSSLEELMAKAKDLHAEGHSSGQIADELSLSVDTVTWLLTQGKAGIAAPKDVHIDWTNVSSNTTLLGGISSMMLAHFEAANEEEEGVDAVIGISVSGVPLATMIAAEDGLNLAIYHPSKHNPEGKIGSISGNFSKVSQKRCLIVDDCITTGNTLTEIVNYLRRHKATPVGICVIFDKRGVKEIEGVPVYSLFTIKRID
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: SSRP_TREPA
Sequence: MRGTGTHLIAKNRKAFFNYHVEDRLECGIALEGTEVKSVRAGHLSFPDAFAEMRGGELWLKNVHIAEYVHACSFAPNPDRMRKLLAHRDQIARLKRKVEEKGYTLVPLEFYLKAGRVKVALGICKGKKLFDKRAQIKARDNARELSRSLCERHH
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MNHD1_STAAB
Sequence: MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPLRVELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLIGIIGAFTTGDIFNLFVFFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVAILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAPPIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANIKKIILYNVMIAVGVILVGVAMMTESGMIGAIYYTLHDMLVKLALFLLIGIMIKITGTADLRQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSLVVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAGAETFYNPSTYVKAVLGGK
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit D1, Mnh complex subunit D1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL21_CUPTR
Sequence: MYAVVKTGGKQYKVAAGEKLKVEQIPADIGAEITLDQVLAVGAGDQIKFGTPLVSGASVKATVISQGRHDKVKIFKMRRRKHYQKRQGHRQNYTELRIEAIVA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: HIS6_CUPTR
Sequence: MLAKRIIPCLDVTNGRVVKGVNFVELRDAGDPVEIARRYDEQGADEITFLDITATSDGRDLMLHIIEDVASQVFIPLTVGGGVRTVEDVRRLLNAGADKISVNSSAIANPQLVSDATARYGSQCIVVAIDAKRSSAPGEAPRWEVFTHGGRKATGLDAVQWAREMATRGAGEILLTSMDRDGTKSGFDLELTRAVSDAVPVPVIASGGVGGLQDLADGITRGRADAVLAASIFHYGQHTVGEAKAFMAREGIPVRI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_RHORT
Sequence: MRRFDIGWKTYLLPEIHPEGWRFISIFAAVTFGLWLWQDWLVVPGLVLTIWCVYFFRNPKRTVPDRLGLVVTPASGIVQMVGLVDPPAELALDPPGPRQRISVFMSVFDCHVNRCPVGGTVRKIVYAPGKFVNATLDKASADNERNSVVLDIGQSRDLAFVQIAGLVARRIRCDLVEGQSVLTGEIMGLIRFGSRLDIYLPPGAAPLVAPGQSCISGETVLADLASAEPERLGVLR
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GATC_THEPX
Sequence: MAISRSEVEHVAKLARLKFSQEEIEEFTVQLSKIIDYVNKLNELDTENVEPTAHIVPIHNVFREDEVKPSMDRDKILMNAPYKENGCFKVPKIIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.