PharMolix/UniProtQA huggingface dataset:
Protein: MNMA_AZOSB
Sequence: MKVVVGMSGGVDSSVTALLLKQQGYEVTGLFMKNWEDDDDDEYCSTRQDLVDVASVCDVIGIDLEVVNFSAEYKDRVFADFLREYEAGRTPNPDILCNSEIKFRCFLDHAMQLGAERIATGHYAQVREWINDGRSEFQLLKAEDGTKDQSYFLYRLNQAQLAKTLFPLGGLYKREVRKIAEAAGLHVATKKDSTGICFIGERPFREFLMRYLPTKPGEIRCLDDDRVLGEHQGLMYHTIGQRKGLHIGGIKGNQDEAGEHEAWYVAKKDVKANVLYVVQGHDHPALLKDRLLATDLNWIAGRDPRTHWVYTAKPRYRTADMPCEIDALGEGRAEIAFATPQWALTPGQSVVVYESKVCLGGGVIV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GEP3_YEAS2
Sequence: MLNLCHALRGVRQFSCSVIVKVKCASCSIKLQDQDPSKPGYYTKPKSLPDSKLNPDLQDLKYLLFSQDIQLSKQAIQNDPDLKTKRDLLLRVICKRCSNALHHNNYNPEEFPESTLNDILNYVPRGSNVMHIVPFVEFPLHLDPNVLKRNDLDTTLVLTKSDQVFKDKNAVSKKVPIFMKQFLKNTLRIDSNKTFAISALKNWNISMFYNYFKNYTYLLGNPNVGKSTLINTLLQKYLGYKVKIDSTGKINSPSEEVMQEAFTNPKNFFKIQAAGVSHIPNLTRSVQAYQVGGKILFDLPGYSTSTSRLRLEEPIDERWLQRLRKTDLFNRKHIKQKTYESMKGTSQGGCYTVGGIFYLVPPKGSINQIVKYIPGPSKTFKNIEKGIDVFNSCNSSSGTHPLSRYCGIKSVICEKSQYKRYAIPPFIGSIEIVLKDIGYILLRTTGRYEFKGLHEIWIPRGIQVGIREPLENLIESGYQRYIETNGKESSCPRDRPIISSLYEMAPDEADTLNAVKKSYLEKTEKDLSARRFVDDDPYDLVQHLEKKKNPYWYYQW
What is the function of this protein?
Interacts genetically with prohibitins and thus may be involved in the mitochondrial lipid metabolism.
What are the official names of this protein?
Genetic interactor of prohibitins 3, mitochondrial, Altered inheritance of mitochondria protein 40, Found in mitochondrial proteome protein 38.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: INF2_MOUSE
Sequence: MSVKEGAQRKWAALKEKLGPQDSDPTEANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCSQQYRFSVIMSELSDSDNVPYVVTLLSVINAIILGPEDLRSRAQLRSEFIGLQLLDILTRLRDLEDADLLIQLEAFEEAKAEDEEELQRISDGINMNSHQEVFASLFHKVSCSPASAQLLSVLQGLMHLEPAGRSGQLLWEALENLVNRAVLLASDAQACTLEEVVERLLSIKGRPRPSPLDKAHKSVQTNSVQNQGSSSQNTTTPTTKVEGQQPVVASPCQHVGSIQSSSVDIAPQPVALEQCITALPLPTPPLSSSTPVLPPTPPPLPGPGATSPLPPPPPPLPPPLPGSGTTSPPPPPPPPPPLPPPLPGSGTISPPPPPPPPPLPGTGAVSPPPPPPLPSLPDSHKTQPPPPPPPPLPGMCPVPPPPPLPRAGQIPPPPPLPGFSVPSMMGGVEEIIVAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATLGSPCTAAVEPDFSSIEQLFSFPTAKPKEPSAAPARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTSMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPLRVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPPSQAAGINVEIIHSEASANLKKLLEAERKVSASIPEVQKQYAERLQASIEASQELDKVFDAIEQKKLELADYLCEDPQQLSLEDTFSTMKTFRDLFTRALKENKDRKEQMAKAERRKQQLAEEEARRPRDEDGKPIRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTEASGRVAPTDPPKATEPATASNPTQGTNHPASEPLDTTAADEPQGWDLVDAVTPSPQPSKEEDGPPALERRSSWYVDAIDFLDPEDTPDAQPSEGVWPVTLGDGQALNPLEFSSNKPPGVKSSHQDATDPEALWGVHQTEADSTSEGPEDEAQRGQSTHLPRTGPGEDEDGEDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVQGRVSKGTSKRRKKRPSRNQEEFVPDSDDIKAKRLCVIQ
What is the function of this protein?
Severs actin filaments and accelerates their polymerization and depolymerization.
What are the official names of this protein?
Inverted formin-2.
What is the protein family that this protein belongs to?
Belongs to the formin homology family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: CORT_BISBE
Sequence: MGVGSSLRMQLTAQKPRVDRFVVPRYSLPEIHRRMTWSDRCEKYNGEIWSSKYLQQKRYINFLDEAFGLAPLKAQQRNSDTFDDWCWPCAPRKKSYLSTADNVLDLPSYSITSFPDVLDWSHDDILVAALGKKYHKWSWRTQSPVDQGQTMFDIRCCKFDPKGKRLLLGTDMRVEVHNELSKCQFVQYCKCNIQICTITAIDWSPTGNSFVTGCSRGRICAMNEKDFPIKSLVLIEGAMLVVKISPNARYVAVAGVHKHRVWILSWPDLIRFRFMKTNEIVKDLNWHPWQTALLGVATLSSDRHASMIIWEPHATDKLRQQDVGRGRYSIDAMRFNNKTGELLLSLWSLDVNVPYPKSSELVVMSNFDTVVDHWGESHTGLNRIRTMVFSPDGTKLATATADEDLIIWNFLPNDYKKILARKKFTAFPQFLDICSYGYTIR
What is the function of this protein?
Controls wing pigmentation patterning, possibly by regulating scale cell development (PubMed:27251284).  Probably acts as an activator of the anaphase promoting complex/cyclosome (APC/C) that promotes the ubiquitin ligase activity and substrate specificity of the APC/C (By similarity).
What are the official names of this protein?
Protein cortex.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CORT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP17A_CAVPO
Sequence: MWELVTLLGLILAYLFWPRQGSSGTKYPKSLPSLPVVGSLPFLPKSGHMHVNFFKLQKKYGPIYSFRLGSTTTVVIGHHQLARELLIKKGKEFSGRPLTTTVALLSDNGKGIAFADSSATWQLHRRLVLSSFSLFRDGEQKLENIICQELSALCDFLATCDGQVKDLSSSIFMTVVNIICMICFSVSYKEGDMELVTIRRFTTGFVNSLSDDNLVDIFPWLKIFPNKTLEMIRKYTEIRGAMLSKILKECKEKFRSDSVSNLIDLLIQAKVNENNNNSSLDQDSNLFSDKHILTTLGDIFGAGVETSSSVVLWVIAFLLHNPQVKKKIQEEIDHNVGFSRTPTFSDRNHLLMLEATIREVLRIRPVAPILIPHKANTDSSIGEFAIDKDTNVLVNLWALHHNEQEWDRPDQFMPERFLDPTGSQIIVPSSSYLPFGAGPRSCVGEALARQEIFLITAWLLQKFDLEVPEGGQLPSLEGIPKIVFLIDPFKVKITVRPAWKEAQAEGSA
What is the function of this protein?
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis.  Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways.  A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage.  The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol.  Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione.  Has 16-alpha hydroxylase activity.  Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA.  Also 16-alpha hydroxylates androgens, relevant for estriol synthesis.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Microsome membrane.
Protein: NDK_PSEA7
Sequence: MALQRTLSIIKPDAVSKNVIGEILTRFEKAGLRVVAAKMVQLSEREAGGFYAEHKERPFFKDLVSFMTSGPVVVQVLEGEDAIAKNRELMGATDPKKADAGTIRADFAVSIDENAVHGSDSEASAAREIAYFFAATEVCERIR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM44_CAEEL
Sequence: MFRHVAQNLGSRNTSIQSYRLLRTRWERGYLKDLYHRRQILGADPAISRSSYPNWDYDSELYAFGHRIGAPEISEDQYIKALTNESFFQRADVEENVESAQPGAEVGTEHNAELVKRGEQNLSIWLKRYLRFHLAKAPEELIEAIDSHLLDDECLAGIASHLGIDHLVRTKEFPISQESSADAFRALAGVFSDEKVKNLVIDFIVPQLVDIDFADIYPLADPLAVVTDLLKSNGVTEIEPRVLRSAGENSAEPIYVVAIYADKLKNVGQSAGESLAIAVDMAAREALLRLWDITSEKVLFFGDRAANVPLERYSQPNFSLSQKCSPGTNTNIIDHSQPVESPDNLIEAVLRYRNVVDAEVGKSYTKRLRHKFSRGSLAKRSFRYLVKPKPYTVA
What is the function of this protein?
Component of the mitochondrial ribosome.  May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.
What are the official names of this protein?
Ribosomal protein L44, mitochondrial, Mitochondrial large ribosomal subunit protein mrpl-44.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1460_VIBCH
Sequence: MRYFLLFLTLLFLSPSVTASAINCDPNTTTSHQLLFGFGSPIVQSVLFDGCMLDIEKDDYGFVWSCLSNENGDYCKGLYKPRFSQGVSPNWPMCDLSGASAERCIYPYCPEGEECVPLPPSPPSDSPVDGLSSSFKSAFNQVYKNQSEMASTLNHVSGQVSHSQDMVQLNTKFHADRVLESVTAVNNRLGGQMEYLEEIRIDVWDTQREVRKAKDELYSRVAAVSYDVLYSELNVLRAIDELKDSLGGTVVPPNPDQPNPTPPDSSSPNYTGALNTISKKLNTLETISQQLDTMNTALSGRCSNPERCQFPIREAETELETAQQNLKQMINEKITQSALHQFKGSAAVPSFCSYVEAFGYNLCFDFSLFSENLHIIRMIVLAMAYILAAMLILFR
What are the official names of this protein?
Uncharacterized protein VC_1460, OrfU.
Protein: RS181_MYCPA
Sequence: MAKSNKRRPAPEKPVKARKCVFCAKKDQAIDYKDTALLRTYISERGKIRARRVTGNCVQHQRDIAIAVKNAREVALLPFTSSAR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RL10E_THEAC
Sequence: MVTKPARMYSRITGPAYTRKEFMGGVPYPKITTFVQGNQKKDFPIEMRLVAEEPCQIRHTALEAARVSVNRRMTEAAGLDYFYLKVVPYPHHVLREHKMATGAGADRISSGMRAAFGRPVGTAARVYPDDVIMIARTDEAHAKELKTALRKAAIKLPTPCKVVITKGKEIAGSLGI
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ENO_HYDCU
Sequence: MSLIKDIKARQVIDSRGNPTVEADVILDDGSKGRGISPSGASTGSREAIELRDGDKSKFGGKGVLKAVNNINTEIRDLLIGKEATDQAAIDNAMIALDGTDNKARLGANAILAVSIAVAQAAAQSKGLPLYAYLKTDDYKMPVPMMNIINGGEHADNSVDFQEFMIMPVGAPSMSEAIRYGAEIFHALKKVLHDKGYNTAVGDEGGFAPDLKSNEEAITVILEAIEAAGYKAGEDIMIAMDAASSELYKDGKYFLGSENKTLTSKEMVDLLSDWVTKYPIISIEDGLDESDWDGFKYQTEKDGKRLQIVGDDLFVTNPKILKEGIEKGIANSILIKINQIGTLTETFEAIQMAKDAGYTAVVSHRSGETEDTVIADIAVATGAGQIKTGSLSRTDRIAKYNQLIRIEEELGSKAVYPGKDAFYNLK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: NUSB_SALNS
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLSGVATNSAYLDGLMKPYLSRLLEELGQVEKAVLRIALFELSKRSDVPYKVAINEAIELAKTFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: Y1019_SYNY3
Sequence: MRYGFYTLDVFTDQLFGGNPLAVFPDAEGLTDGQMQKIAAEINYSETVFVLPPVTETGNFRLRIFTPKRELDFAGHPTIGTTYLLGLLQPPSPLVTTTWQLEEPVGLVPVTLHYKQGQLVQTELTVAQLPQTKDSAPSCEDLALLLGLSIDQLQQGEYEPQAYSCGLPFLFIPLINEEALNRISFNPSVWQNLLAGQWADCVYCLAPGDPSLGLSDNKLIHGRMFAPGLGIAEDPATGSGVAALGGYLDDRLDTPGSHHWQIEQGKALGRPSQLQLTVVKDGQGIRAVKVAGRSVLVSEGFMNLGN
What are the official names of this protein?
Uncharacterized isomerase slr1019.
What is the protein family that this protein belongs to?
Belongs to the PhzF family.
Protein: BCHE_RUBGE
Sequence: MRVLFIHPNYHSGGAEIAGNWPPAWVAYLAGYLKAGGYTDVIFVDAMTNDLSEDQVREKITTLKPDIVGCTAITPAIYKAERTLQIAKEVNPDIVTVLGGIHGTFMYPQVLKEAPWIDAIVRGEGEQVMLNLVTAVDQGRFMADRNCVNGIAYAAPDGKVVATPAEPPIEDLDRITPDWGILEWEKYIYIPMNKRVAIPNFARGCPFTCSFCSQWKFWRDYRIRDPKKVVDEIEVLVKQHDVGFFILADEEPTIHRKKFIEFCEELIKRDLGVLWGINTRVTDILRDEKLLPLFRKAGLIHVSLGTEAAAQLKLDMVNKETTIEQNKRAIQLLKDNGIVTEAQFIVGLENETAETLEETYKMARDWNPDMANWAMYTPWPFSDLFQELGDKVEVFDFEKYNFVTPIMKPDAMDRGELLDRVMSNYRRFFMNKAFLQYPFTKDKERRKYLMGCLKAFLKSGFERKFYDLGRVGYWGPQTKKTVNFSFDKNRRIDAQTADELSRVDDGWVTMHGPKIEMRRRKGDDNFEIAKAAMACGGGTEQLTEEQQAATEVRAS
What is the function of this protein?
Involved in the tetrapyrrole biosynthetic pathways leading to chlorophyll and bacteriochlorophyll (BChl).  Catalyzes the anaerobic formation of the isocyclic ring (E-ring) in Mg-protoporphyrin monomethyl ester (MPE) to yield protochlorophyllide a (PChlide a) via a six-electron oxidation and the formation of an oxo group at position C13 using oxygen from a water molecule.
What are the official names of this protein?
Anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase, MPE cyclase.
What is the protein family that this protein belongs to?
Belongs to the BchE family.
Protein: NDK_CERSK
Sequence: MAIERTLSIIKPDATRRNLTGKINAKFEEAGLRIVAQKRIHLSLAQAQKFYGVHKDRPFFGELTEFMASEPVVVQVLEGEGAIAKNREVMGATNPANADAGTIRKEFALSVGENSVHGSDAPETAAEEIAFFFSGLELVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHK_CUCSA
Sequence: MNSIEFPLLDRTTQTSVISTTSNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDAITKLRKKISREIYEDRIKSQEENRCFTTNHKFHVGPSTHTGNYDQELLYQPSSTSEIIPPETFFKYKSAVSSYELVN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: LHPL3_MOUSE
Sequence: MLPAQEAAKLYHTNYVRNSRAIGVLWAIFTICFAIINVVCFIQPYWIGDGVDTPQAGYFGLFHYCIGNGFSRELTCRGSFTDFSTLPSGAFKAASFFIGLSMMLIIACIVCFTLFFFCNTATVYKICAWMQLTFAACLVLGCMIFPDGWDSDEAKRMCGEKTDKYTLGACSVRWAYILAIIGILDALILSFLAVVLGNRQDSLMAEELKAENKVLLSQYSLE
What are the official names of this protein?
LHFPL tetraspan subfamily member 3 protein, Lipoma HMGIC fusion partner-like 3 protein.
What is the protein family that this protein belongs to?
Belongs to the LHFP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PXPA_ACIBT
Sequence: MFVDLNSDLGESFGSWKMGNDDQILPVVTSANIACGFHAGDPLGILKTVRKAVELGVTIGAHVSYPDLVGFGRRNMDLSRDELIADVLYQISALDGLAKVAGSKVQYVKPHGALYNTIAHDQAQAAAVIDAIKMYNPELVLVALAGSNLVEQARVAGLKVVSEAFADRAYNSDGSLVSRRLEGAVLHDSAFVASRVVSMLKNGGVESIDGVFTPIQADTICLHGDTDGALEMSAAIKAELVKNNIEIRPFVNKA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: PIG1_CLAP2
Sequence: MVDKFLIETDQNEFQPNLWKNGDSDRLPNRCPETQLNVLVVGAGPSGLMTALECWRKGHNVVKILERSNSPVFTGDVIVIGPSALRAFRHWPDMCAELEKSKMDSIMYYRKHNGELILGPTSLGHNDPEYTAAWKGIPFAAPHQIRKDFYRMLLRQVARVGIRVEYGQRVEKYFDDEAAMLGGVITDQGTIMFADLVVAADANRTRSDLLIAGAHTPSRSSGMSVYRTAFPTERALQDEAFRTRWGDAIEKGISHHEFWMGPGMHLGLFISPEFVAFGLTPRDSFLHEGGNEPIESWEPDVDPEEVTKVLNRVPDWNPVIKSLVKNTQRGSIVHWPLLWRNLRREWTSKSGRVVQAGDAAHSSIPASISGGTLALEDAVTLASCLHLSCSSAGSKGAPLGARIYNLLRYQRVSCVQKMSFVNAEGLSGSSMEDAIKENPESVRVRFPRWLYRHDPEAYVYEKYGQAFAHLVEGTDFENTNLPPGHTFEPWTIEQIHKDMMAGKRVADFLDGDWS
What is the function of this protein?
FAD-dependent monooxygenase; part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia (PubMed:28955461).  The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones endocrocin and clavorubin (PubMed:28955461).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) CPUR_05437 (By similarity).  The atrochrysone carboxyl ACP thioesterase CPUR_05436 then breaks the thioester bond and releases the atrochrysone carboxylic acid from CPUR_05437 (By similarity).  The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (By similarity).  The next step is performed by the anthrone oxygenase CPUR_05434 that catalyzes the oxidation of emodinanthrone to emodin (By similarity).  Emodin is further modified to yield monodictyphenone via several steps involving CPUR_05427, CPUR_05428, CPUR_05429 and CPUR_05430 (By similarity).  The short chain dehydrogenase/reductase CPUR_05418 then catalyzes the C-5 ketoreduction to give the xanthone skeleton of the monomeric units (PubMed:32105084).  Ergochromes formation requires further dimerization steps of different xanthone units, probably catalyzed by the cytochrome P450 monooxygenase CPUR_05419 (PubMed:28955461).  CPUR_05425, CPUR_05426 and CPUR_05431 are unique to Claviceps, thus it is likely that they are involved in further modification of xanthone units or in their dimerization (PubMed:28955461).  The yellow ergochromes and the red anthraquinone pigments endocrocin and clavorubin are products from the same PKS derived precursors and the latter are likely shunt products in the pathway of xanthone biosynthesis (PubMed:28955461).  It is proposed that atrochrysone carboxylic acid released from the PKS CPUR_05437 can also be converted to endocrocin anthrone which is further oxidized into endocrocin by CPUR_05435 (By similarity).  Endocrocin could be then modified to clavorubin, possibly by CPUR_05423 and CPUR_05431 (PubMed:28955461).  Clavorubin is the principal anthraquinone metabolite produced by the cluster with a much higher yield compared to endocrocin (PubMed:28955461).
What are the official names of this protein?
FAD-dependent monooxygenase CPUR_05423, Ergochrome gene cluster protein CPUR_05423.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: EFTS_BURP0
Sequence: MAAITASMVAELRAKTDAPMMECKKALTEADGDMAKAEELLRVKLGNKASKAASRVTAEGVVASFVGANAGALVELNCETDFVAKNDDFNAFAKTVAELVATQNPADVAALSALPLDGKTVDEVRLALVGKIGENISIRRFVRFETSNKLATYLHGSRIGVIVEYTGAQEQVGKDVAMHVAAMKPVSLSADEVPADLIEKERRVAEQKAAESGKPAEIVAKMVDGSVQKFLKEVSLLNQPFVKNDKQTIEQMLKAADAAVQKFALFVVGEGIEKRQDDFAAEVAAQVAAAKQQ
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALSB_ARATH
Sequence: MRRQRPSVATARDAPSLEVYNIIPIHDFLTEHPSLRYPEVRAAAAALRIVGDLPKPPFADFTPRMDLMDWLGLLFGFQIDNVRNQRENLVLHLANSQMRLQPPPRHPDGLDPTVLRRFRKKLLRNYTNWCSFLGVRCHVTSPIQSRHQTNAVLNLRRELLYVALYLLIWGESANLRFMPECLCYIFHHMAMELNKVLAGEFDDMTGMPYWPSFSGDCAFLKSVVMPIYKTVKTEVESSNNGTKPHSAWRNYDDINEYFWSKRALKSLKWPLDYTSNFFDTTPKSSRVGKTGFVEQRSFWNVYRSFDRLWILLLLYLQAAIIVATSDVKFPWQDRDVEVALLTVFISWAGLRLLQSVLDASTQYSLVSRETYWLFIRLTLKFVVAVAWTVLFSVFYARIWSQKNKDGVWSRAANERVVTFLKVVFVYVIPELLALVLFIVPCIRNWVEELNLGVVYFLTWWFYSKTFVGRGMREGLVDNVKYTLFWIIVLATKFIFSYFLQIRPLIAPTRALLNLKDATYNWHEFFGSTHRIAVGMLWLPVILVYLMDLQIWYSIYSSLVGATIGLFSHLGEIRNIDQLRLRFQFFSSAMQFNLKPEEHLLSPKATMLKKARDAIHRLKLRYGIGQPFNKIESSQVEATWFALIWNEIILTFREEDLISDREVELLELPPNCWNIRVIRWPCFLLCNELLLALSQANELCDAPDHWLWSKICSSEYRRCAVMEAFDSIKFVILKIVKNGTEEESILNRLFMEIDENVENEKITEVYKLTVLLRIHEKLISLLERLMDPEKKVFRIVNILQALYELCAWEFPKTRRSTPQLRQLGLAPISLEADTELLFVNAINLPPLDDVVFYRQIRRVHTILTSRDPMHNVPKNIEARERLAFFSNSLFMTMPQAPSVEKMMAFSVLTPYYDEEVMYRQEMLRAENEDGISTLFYLQRIYEDEWVNFLERMRREGAENENDIWSKKVRDLRLWASYRGQTLSRTVRGMMYYYSALKKLAFLDSASEMDIRMGTQIAPEARRSYYTNDGGDNTLQPTPSQEISRMASGITHLLKGSEYGSAMMKFTYVVACQVYGQHKARGDHRAEEILFLMKNHDALRIAYVDEVDLGRGEVEYYSVLVKFDQQLQREVEIYRIRLPGPLKLGEGKPENQNHALIFTRGDAIQTIDMNQDNHFEEALKMRNLLESFKTYYGIRKPTILGVREKVFTGSVSSLAWFMSAQETSFVTLGQRVLANPLKVRMHYGHPDVFDRFWFVPRGGISKASRVINISEDIFAGFNCTLRGGNVTHHEYIQVGKGRDVGLNQISMFEAKVASGNGEQALSRDVYRLGHRLDFFRMLSFFYTTVGYYFNTMLIVFTVYAFLWGRLYLALSGVEKIAKDRSSSNEALGAILNQQFIIQLGLFTALPMILENSLERGFLPAVWDFITMQLQLASFFYTFSMGTRTHYFGRTILHGGAKYRATGRGFVVEHKKFAENYRLYARTHFIKAIELAIILLVYAAYSPLAKSSFVYILMTISSWFLITSWIISPFLFNPSGFDWLKTVNDFDDFIAWLWSRGGLFTKADQSWFTWWNEEQEHLKTTGVWGKLLEIILDLRFFFFQYSIVYHLRIAENRTSIGVYLISWGCIIGIVAIYITTIYAQKRYSVKEHIKYRFIQFLVILLTVLVVVMMLQFTKLTVVDLLISLLAFVPTGWGLISIAQVLKPFLLSTVVWDTVISVARFYDLFFGLIVMAPVALLSWLPGFQNMQTRILFNEAFSRGLQISIILAGKKST
What is the function of this protein?
Required the formation of the callose wall separating the tetraspores (interstitial wall), but not for the callose wall surrounding the pollen mother cells (peripheral wall).  Functionally redudant to CALS12 (GSL5).  During plant growth and development, callose is found as a transitory component of the cell plate in dividing cells, is a major component of pollen mother cell walls and pollen tubes, and is found as a structural component of plasmodesmatal canals.
What are the official names of this protein?
Callose synthase 11, 1,3-beta-glucan synthase, Protein GLUCAN SYNTHASE-LIKE 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 48 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPT_BRUAB
Sequence: MSDPRHIAIIMDGNGRWAKARGLPRSAGHRAGVEALREIVRAAGDRGLGYLTLFAFSSENWTRPSGEVSDLLGLLKLFIRRDLAELHRNNVRVNIIGERAELAANIRALLNEAESLTHRNTGLNLVIAFNYGSRDEIVRAVRSLARDVAAGLLDPSSISAELVSANLDTAGIPDPDLIIRTSGEMRLSNFLLWQAAYSEFLFLPCHWPDFRPADLDAAYETFRQRERRFGGVEPRASADAEEEILCPSTKGAAV
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: RSMG_CLOBM
Sequence: MEFFNILQSSCNDVNLDFNDKKYNQFISYKNLIQEWNKKVNLTAIVEDEEIIKKHFIDCIKIFKASPIGEAKSLIDIGTGAGFPGIPIKILREDIKITLLDSLQKRINFLNIVIGDLKLKDIQCLHGRAEDYAQEAEHRQKYDVAVSRAVANLAVLSEFCIPFVKKGGYFIAMKGPSVEEEITVATKSIEVLGGKIEDIIKIDIEDTDLKHNLVIIKKVKETEKKYPRKPGIIKKDPLK
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.