PharMolix/UniProtQA huggingface dataset:
Protein: STKP_STREE
Sequence: MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMRQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVAFAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQNPLPSVIAENSSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYNRRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKNPSQAVTEETYQPQAPKKHRFKMRYLILLASLVLVAASLIWILSRSPATIAIPDVAGQTVAEAKATLKKANFEIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSVEGMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP
What is the function of this protein?
Protein kinase involved in signal transduction pathways that regulate various cellular processes.  Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates.  Plays a crucial role in the regulation of cell shape and cell division of S. pneumoniae through control of at least DivIVA activity.  Is involved in competence triggering, via the transduction of signals culminating directly or indirectly in ComD activation.  Is important for the resistance of S. pneumoniae to various environmental stress conditions.  Appears to be a global regulator that positively controls the transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake, and oxidative stress response, and that seems to down-regulate genes employed in competence.  Since StkP is unlikely to directly regulate transcription, the input signal must be transmitted through an effector molecule.  Identified target substrates that are specifically phosphorylated by StkP in vivo, mainly on threonine residues, are DivIVA, GlmM, PpaC, MapZ, KhpB (also called EloR/Jag) and StkP itself.  Autophosphorylated StkP is a substrate for the cotranscribed protein phosphatase PhpP; PhpP and StkP appear to constitute a functional signaling couple in vivo.
What are the official names of this protein?
Serine/threonine-protein kinase StkP, Ser/Thr-protein kinase StkP, Eukaryotic-type Ser/Thr protein kinase, ESTPK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=The C- terminal PASTA domain is located in the periplasmic space, beneath the peptidoglycan cell wall, and the kinase domain is located in the cytoplasm. However, another study in the virulent strain TIGR4 (PubMed:20223804) showed that the C-terminal PASTA domain is exposed extracellularly. Localizes to the midcell division sites.
Protein: KDSC_SALTI
Sequence: MSKAGASLATCYGPVSTHVMTKAENIRLLILDVDGVLSDGLIYMGNNGEELKAFNVRDGYGIRCALTSNIEVAIITGRKAKLVEDRCATLGIVHLYQGQSNKLIAFSDLLEKLAIAPENVAYVGDDLIDWPVMEKVGLSVAVADAHPLLIPRADYVTHIAGGRGAVREVCDLLLLAQGKLDEAKGQSI
What is the function of this protein?
Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate in vitro.  Also catalyzes the dephosphorylation of phospho-tyrosine in vitro.
What are the official names of this protein?
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC, KDO 8-P phosphatase.
What is the protein family that this protein belongs to?
Belongs to the KdsC family.
Protein: PYRF_ECO27
Sequence: MTLTASSSSRAVTNSPVVVALDYHNRDAAMAFIDKIDPRDCRLKVGKEMFTLFGPQFVRELQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMAAAREALVPFGKDAPLLIAVTVLTSMEASDLADLGVTLSPADYAERLAALTQKCGLDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQGSDAGDQRRIMTPEQALSAGVDYMVIGRPVTQSVDPAQTLKAINASLQRSA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: KMT5C_HUMAN
Sequence: MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRRQQHLRSALETFLRQRDLEAAYRALTLGGWTARYFQSRGPRQEAALKTHVYRYLRAFLPESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREADEGLLRAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEGAFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSGSRQGLLGPRACVHPSPLRRDPFCAACQPLRLPACSARPDTSPLWLQWLPQPQPRVRPRKRRRPRPRRAPVLSTHHAARVSLHRWGGCGPHCRLRGEALVALGQPPHARWAPQQDWHWARRYGLPYVVRVDLRRLAPAPPATPAPAGTPGPILIPKQALAFAPFSPPKRLRLVVSHGSIDLDVGGEEL
What is the function of this protein?
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273).  In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869).  H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression.  Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions.  KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).  Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273).  May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase KMT5C, Lysine N-methyltransferase 5C, Lysine-specific methyltransferase 5C, Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2, Suv4-20h2, [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B, [histone H4]-lysine20 N-methyltransferase KMT5B.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
Protein: HBA_PTEAL
Sequence: VLSSTDKSNVKAAWDKVGGHVGEYGAEALERMFLSFPTTKTYFPHFDLAHGSSQVKAHGKKVGDALTNAVGHIDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLASHLPSDFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CBIA_METM7
Sequence: MKRIVIAGTSSMVGKTTISTGIMKALSKKNNVQPYKIGPDYIDPTYHTEATENKSRNLDSFFMDKLQIRSLFKKHSKNKDISVIEGVRGLYEGISPYNDIGSTASVAKTLNAPVILLMDARSLTRSAAAIIKGFKSFDTELNIKGVIFNKIRGEGHLNKLKEAVKYYDNEIEIIGAIPRDEGLSVSQRHLGLVPTPENKQGLLERIDLWGNTVEECLDIEKIVELSDKSFDFCVDEKNKDETLWKVEKNNSKIAVAFDESFNFYYWDNFDAMEENGAKLKFFSPLNDSEVPDCDTIYLGGGYPEIFSEKLSENKSMIDSIRNFDGKIYGECGGLMYLTNSIDGKEMLKLIDANAVMTPNVQGLSYVKGTFEKDCIIGEKSKEFKAHEFHYSKLININENDFSYRINRGKGIINSMDGITSKGGDIVGGYAHQHCIGNPYFAASLSKI
What is the function of this protein?
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.  Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation.  Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
What are the official names of this protein?
Cobyrinate a,c-diamide synthase, Cobyrinic acid a,c-diamide synthetase, Ni-sirohydrochlorin a,c-diamide synthase, Ni-sirohydrochlorin a,c-diamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CbiA family.
Protein: RNH2_PSEMY
Sequence: MQLGLDFSLVEELVAGVDEVGRGPLCGAVVTAAVILDPLRPIIGLNDSKKLTEARREVLFDEIREKALAWCIARAEVEEIDRLNILHATMLAMQRAVEGLSVTPKLALIDGNRCPRLTVPSAPVVKGDSRVPAIAAASILAKVSRDREMLEMDRLYPGYGIAGHKGYPTPVHLEALQRLGPTPIHRRSFAPVRALLEPVAVDCIAATV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LARP7_DANRE
Sequence: MKVCQRKTIDTEKMSSVGDTACADLSEKKDNEKKKRSRVKQLLSDVKKQVEFWFGDVNLHKDRFMKSIIEQSRDGYIDIAVLTTFNRMKNLTADVKLIARALKNSTIVEVNDEGTRIRRKEPLGETPKDVDSRTVYVELLPKTVTHIWLERVFSKCGHVVYISIPRYKSTRHSKGFAFVEFETQEQAQKAVEMLNNPPEDAPRKPGIFPKTCRKKAVPFDAVTQDNDEDGKKKKTELKNSTSEETGSNNMDQDGMLESTVTSEPNLATLTSTVSKKAKKKRLRSQSFEASSGEDQFEMSSKMRKVEEEKSELKDLSSENKDEELNSLKKKDDSVLKAKRKRKKKLKERLKVGEEVIPLRVLSKKEWLDLKQEYLTLQKRCMAHLKQSVFQINQKPTNYHIVKLKEDDTNAFYKDTPKKELTSGPEFLSGVIVKISYNQPLPSKRCIKDMLSELSPVAYVDLLDGDTEGHVRFKSSEDAQKVIKARFEFQKKYNWNLELLSGDHERRYWQKILVDRQAKLNTPREKKRGTEKLISKAEKIIIAKAKEASNHIRFDD
What is the function of this protein?
RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:26542022).  Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:26542022).  The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:26542022).  The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity).  LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (By similarity).  LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing.  Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (By similarity).  U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (By similarity).
What are the official names of this protein?
La-related protein 7, La ribonucleoprotein domain family member 7.
What is the protein family that this protein belongs to?
Belongs to the LARP7 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: RIMO_BART1
Sequence: MVAPRISFVSLGCPKALVDSERIITSLRSEGYEISRQHQGADVVIVNTCGFLDSARKESLANIDEALKENGKVIVTGCLGADPDVIRQTYPNVLAITGPQAYESVIEAVHTAIPPIHDPFLDLVPPQGIRLTPRHYAYLKISEGCSNRCSFCIIPTLRGDLTSRPISDVLREAEKLVQAGVKELLVISQDTSAYGIDLKYLENSWKDRTIKTKFFDLCRELGDMGIWVRMHYVYPYPHVDEVIELMAAKKILPYLDIPFQHASPTVLRHMKRPALMEKTNRRIEKWRKICPDLTLRSTFIVGFPGETNEDFNMLLEWLEDAKIERAGCFKYEEVKGAVANDLGLENIPEDVKENRWHRFMAKQQQISTHLLKKKIGKRLQVLIDESQGKVAKGRSQYDAPEIDGVVHISSRRPLRVGEFVTVKIEQSDAYDLYGIAV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGD_STAA8
Sequence: MKQYKAYLIDLDGTMYMGTDEIDGAKQFIDYLNVKGIPHLYVTNNSTKTPEQVTEKLREMHIDAKPEEVVTSALATADYISEQSPGASVYMLGGSGLNTALTEAGLVIKNDEHVDYVVIGLDEQVTYEKLAIATLGVRNGATFISTNPDVSIPKERGLLPGNGAITSVVSVSTGVSPQFIGKPEPIIMVKALEILGLDKSEVAMVGDLYDTDIMSGINVGMDTIHVQTGVSTLEDVQNKNVPPTYSFKDLNEAIAELEK
What is the function of this protein?
Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
What are the official names of this protein?
Acid sugar phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. NagD family.
Protein: LTX2A_ECTBR
Sequence: FWGAVWKILSKVLPHIPGTVKWLQEKV
What is the function of this protein?
Antimicrobial peptide forming an alpha-helix in watery and membraneous environments, enabling it to perforate membranes.  Active against Gram-negative bacteria E. coli DH5alpha (MIC=5 uM), E. coli MH1 (MIC=0. 6 uM) and P. aeruginosa PAO1 (MIC=10 uM) and against Gram-positive bacteria B. subtilis VKM B-501 (MIC=0. 6 uM) and A. globiformis VKM Ac-1112 (MIC=0. 2 uM).  Has cytolytic and hemolytic activity.
What are the official names of this protein?
M-ectatotoxin-Eb2a, M-ECTX-Eb2a, Ponericin-Q42.
What is the protein family that this protein belongs to?
Belongs to the ponericin-Q family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLUC_BUCBP
Sequence: MTNQFSSTHFLNITENSEKQRIDNFLRKTFKRLPFNLICKIIRTGQIRINKKRINQNYKLKLGDSVRIPPITIQSDSNKKIKLNTRLSIIFNNMILYEDNYFLILNKPSGMSVHSGSGINYGMIENLRILRPYNRYLDLVHRLDRDTSGVLIIAKKRSILRNLHEQLREKKIKKKYVALVHGVWPDILKSISKPLLKTSSRKNKNIVKIDPKGKESITHFNIKKKYTKNTLISITPITGRTHQIRVHLLHLNYPIVLDAKYGIKKLDYFIKNKFNINRLLLHAESINFFHPKRKKNILITAPLDYVFKTVLKNLI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase C, 23S rRNA pseudouridine(955/2504/2580) synthase, rRNA pseudouridylate synthase C, rRNA-uridine isomerase C.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: PROA_STRPC
Sequence: MTDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKALVDDTQTLLAANQKDLANAKEHGISDIMMDRLRLTSERIKAIAQGVQQVADLADPIGQVIKGYTNLDGLKILQKRVPLGVIAMIFESRPNVSVDAFSLAFKTNNAIILRGGKDALHSNKALVKLIRQSLEKSGITPDAVQLVEDPSHAVAEELMQATDYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDAQADLDMATNIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLEKAINQVQPVEWRADDKALPLFEQAVPAKAEDFETEFLDYIMSVKVVSSLEEAISWINQHTSHHSEAIITRDIKAAETFQDLVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMDLEALTSTKFYINGDGHIRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_DINSH
Sequence: MPELLIELFSEEIPARMQARAAQDLQKLVTNGLVEAGITYAGARAYATPRRLTLVVSDMLAASAPVREERKGPKADAPEKAIEGFLRSTGLGREQLETRETPKGDVLFAVIEKPGRPAAEIVAEVLETTIRNFPWPKSMRWGSSSLRWVRPLHRILCLIRDEEGAEIVPLTVDGITAGDVTEGHRFLAPGEIKVHGFEDYETKLRRAKVILDAEERAEHIWADATNQAFAQGLEVVEDRRLLSEVAGLVEFPVPLMGEIDADFLDLPPEVLQTSMKEHQKFFSVRDLKSGKIVRFVTVANTETTDHGATILAGNRKVLSARLADAKFFWENDLRIARAGMQPWREALENVTFHNKLGSQAARIARIADLAATLAPQVGADPDAARTAAELAKADLSSEMVFEFPELQGLMGRYYAEAAGHPAEIAAVAQDHYQPLGPSDAVPTAPLSIAVALADKLDTLTGFWAIDEKPTGSKDPFALRRAALGVIRIVLENGLRLPLINSVKHHNSENTSRPLFSALVAHAKTDQERADGSKSMSDWKALVARSQDDLLSFFHDRLKVFLRDEGIRHDIIDACLAMEGNDDLLLLVNRARALSETLKTEDGENLLQGFKRANNILTQAEEADGVEYSYGADPKFAETDEERALFAALDTAEAVIDPALEAEDFAAATAAMASLRAPLDAFFEAVQVNAENQILRRNRLNLLSRIRATCLKLADLTRIEG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_ECO27
Sequence: MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU1M_CANAL
Sequence: MQYIELLIMFLSVLLAVAFLTVAERKTLGYMQRRVGPNAVGYYGILMAIADAAKLLLKEIVVPTHADKLILFVSPMISLISALLCWSVIPFAPGVTIYDSNYGFILTLAISSVGVFGTLLAGWSANSKYSLLGSIRSTAQLISYELVLTTIILLCILIGGTMNVSKYIEIQQAIWYGIPLLPLAIIFFIGCVAECARPPFDNVEAESELVSGHMTEYSSSIFVLFFLSEYASILFLSTLTAILFMGGGTGIILGLKANLFAFTYIWVRATLPRVRYDKLINLCWMIFLPILFGSAIAVPAYLYALDAIIILYRPGGL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KAT1_RAT
Sequence: MTKRLQARRLDGIDQNLWVEFGKLTKEYDVVNLGQGFPDFSPPDFATQAFQQATSGNFMLNQYTRAFGYPPLTNVLASFFGKLLGQEMDPLTNVLVTVGAYGALFTRFQALVDEGDEVIIMEPAFDCYEPMTMMAGGCPVFVTLKPSPAPKGKLGASNDWQLDPAELASKFTPRTKILVLNTPNNPLGKVFSRMELELVANLCQQHDVVCISDEVYQWLVYDGHQHVSIASLPGMWDRTLTIGSAGKSFSATGWKVGWVMGPDNIMKHLRTVHQNSIFHCPTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMELNRDHMIRSLQSVGLKLWISQGSYFLIADISDFKSKMPDLPGAEDEPYDRRFAKWMIKNMGLVGIPVSTFFSRPHQKDFDHYIRFCFVKDKATLQAMDERLRKWKELQP
What is the function of this protein?
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:7796908, PubMed:6783036, PubMed:2072101).  Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites.  Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:8502223).
What are the official names of this protein?
Kynurenine--oxoglutarate transaminase 1, Kynurenine--oxoglutarate transaminase I, Cysteine-S-conjugate beta-lyase, Glutamine transaminase K, GTK, Glutamine--phenylpyruvate transaminase, Kynurenine aminotransferase 1, Kynurenine aminotransferase I, KATI.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
[Isoform 2]: Cytoplasm, cytosol. SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix.
Protein: RL13_RICB8
Sequence: MKTYSAKPSEIEKKWWVIDAKNVVLGRLASRVANMLRGKHKPSFTPHMDCGDNIIIINAEHVTLTGKKANPKDGKIYYRHTGFPGGIKDTTAGKILSGKHPERVIKMAVKRMITRNALGAKQMSNLYIYANSEHPHAGQQPVVYDFASQNPKNKK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: Y4102_COLP3
Sequence: MLLVVSPAKKLDFESPLATEKFSQPGLLEQSQLLIDDCIKLSPSEIASLMKLSDKLAGLNAARFGQWSTPFTQDNARQAILSFNGDVYTGLDAQSFSDEDFEFAQKNFRILSGLYGLLKPLDLMQAYRLEMGCKLGNSRGDNLYQFWGEIITDELNKTLSELDDDVLINLASTEYFKSVKKKSLNATIITPTFKDWKNGQYKIISFFAKKARGLMARYIIQNKLTSVEQIKTFDLAGYQYNEAMSKDNDWVFTRKES
What are the official names of this protein?
UPF0246 protein CPS_4102.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: UBB_RAT
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGY
What is the function of this protein?
Exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
What are the official names of this protein?
Polyubiquitin-B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.