Protein: UNC40_CAEEL
Sequence: MILRHFGFILIILTVYLSSTHATTRKHHRRSIDNDARNLGFQFVMEPRRNVTVMESSSHLLECSYVLAHERLVHDVRIEWKRDGVLLSERTSSRIKVMSNGSLWIESVSSAEEGTYQCAVHVTTKSDQTSDTWTFLSRKATLRLADLAKFELQAIDRTLAKGQPTAFHCLINSKPTPTAVWLHNDEPIVNGGEYHILPVSNTLEISSTQSRHEGTYRCTVEGAGKRRSSQTARLTVTTETVSNELVFITTPRLQVVEQGDEFLLECLVASLIRPQVRWLKDSRQIIVDGVRIRRVGVSSILVSRASIEDTGLYTCRASNNDDSIDRAVSVEVRAPPRITTRPTTKVAVETADVELECGTAAARPEARVNWYKNGEAIIGSEYFVIEPNRLRILGVVRADQAIYQCIAENDVGSEQASAQLLVDAPDSSSVAASSGVPMTSSAPLGLRSTSSGSRFINVEWDPPVQRNGNIMRYHIFYKDNLIDRERMINSSSTSATLTSLQPSTMYLIRVTAENEAGMGKFSDSLKVTTNKEQAVPGKVASLTTTATGPETIDIRWSPPSGGQPALRYKIFYSHDPLEKNEKETLITTSTTHYTLHGMDKYTGYQIRIEAEGSNGSGLSSDTVKVRTQSDEPSAPPVNIQAEADSSTSVRVSWDEPEEESVNGEITGYRLKYKTKARGAKGNTLVIDATAREYTMGNLEPNTQYLIRMAVVNHNGTGPFSDWVSIDTPGQDKEERTLGAPREIRPHAGIDYILVSWLPPADEQNLVRGYQIGWGLSVPDTETIRVTASTTQYKIARLHSERDYVISLRAFNNLGSGFPIYETVRTLSRETPSHFNEDSDSDDSDVGSSESTPVGVRAEAISATSIRVMWTESDETAFNTQYTVRYSTAVDGNQHRYVNSTETWATVEGLRPATEYEFAVRAVASNGQLSTWSMATRNRTLAAPPSSAPRDLTVLPAESGDPHSSSLHWQPPKYSNGEIEEYLVFYTDRASLADKDWTINYVAGDKLSHQVSNLLPKANYFFKIQARNEKGHGPFSSVVGYTPSGGAILSGKDRHNARGHGSAASGDTVSLVDQLQSLLHSNPLYLILLAAFALILILTLILIIMCCWKRSSGGGRKNGYQSGKKTSAGAGSGGGIGGLGGPPNDLWINGTGSHMRAGASDYMVDGLATAHLTAADIESPTPRYHHLQGQGTLTRSYHQSSQSLEGRQRTPQVVYTGTGRHQPIQRIDFESPYGSSSAIGSASTPPLPMQAPPSGPPTVIDGYRTLRGTPPNSSAANALRSFTQLAGATPPPPHSAASSSSRPTIIAAGGRQVPVGRATAQPRVNVANIYSPFASCSASSDAGESDKKSGECMEMRETTPIKSNTAGSSNGEKMNTNMNPSHSAEDLNAHLENLDTMLDDLQQLQHNLHFETSMDK
What is the function of this protein?
Receptor for netrin unc-6 required for asymmetric axon formation, axon guidance and cell migrations (PubMed:16520734, PubMed:8861903, PubMed:11454756, PubMed:22426253, PubMed:9473333).  Required during axon formation, in response to unc-6, to initiate, maintain and orient asymmetric neuronal growth, and may signal via phosphoinositide 3-kinase (PI3K) (PubMed:16520734).  Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:8861903, PubMed:11454756, PubMed:22426253, PubMed:9473333).  Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:8861903, PubMed:11454756, PubMed:22426253, PubMed:9473333).  Involved in dendritic morphogenesis; may act by localizing unc-6 at the tips of growing dendrites for interaction with unc-5 on the apposing branch to induce mutual repulsion (PubMed:22426253).  Involved in the ventral-dorsal and anterior-posterior migration of gonadal distal tip cells (DTCs) along the body (PubMed:11454756).  Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail (PubMed:24004945).  Positively modulates a TGF-beta-like signaling pathway, independent of its role in unc-6 mediated axon guidance, in association with RGM drag-1 (PubMed:24004951).  Mediates attraction of muscle plasma membrane extensions, known as muscle arms, towards the secreted madd-4 guidance cue, enhanced by interaction with the coreceptor eva-1 (PubMed:25122090).
What are the official names of this protein?
Netrin receptor unc-40, Uncoordinated protein 40.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. DCC family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.