PharMolix/UniProtQA huggingface dataset:
Protein: TRXR1_HUMAN
Sequence: MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
What is the function of this protein?
Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063).  Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).
What are the official names of this protein?
Thioredoxin reductase 1, cytoplasmic, TR, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Peroxidase TXNRD1, Thioredoxin reductase TR1.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm.
Protein: SAHH_ACIAC
Sequence: MSAVLKPQADLAIADISLADWGRKEIKIAETEMPGLMAIREEFAAAQPLKGARITGSLHMTIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAIKGESLEDYWDYTHRIFDFGAKGTPGEGPNMILDDGGDATLLMHLGQRAEKDLSVVANPTSEEERILFAAIKAKIAQDPTWYTRKSAEIIGVTEETTTGVHRLNEMSAKGTLLFRAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKVALVAGYGDVGKGCAQALAALRAQVWVTEIDPINALQAAMEGYKVVTMEYAADKADIFVTTTGNKDVIRHEHMVAMKNEAIVCNIGHFDNEIDVASIEKYRWEEVKPQVDHVIFPDGKRITLLAKGRLVNLGCATGHPSFVMSSSFANQTIAQIELFTKPDAYQAGKVYVLPKVLDEKVARLHLKKVGAQLTELTDAQAAYIGVKKEGPYKADTYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROQ_YERP3
Sequence: MENQPKLNSSKEVIAFLAERFPLCFTAEGEARPLKIGIFQDLVERVQGEENLSKTQLRSALRLYTSSWRYLYGVKVGAERVDLDGNPCGVLEEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAIAAGETPEPRRPRPAGKKPAPRREAGAAPENRKPRQSPRPQQVRPPRPQVEENQPRPVPVTDISKLQIGQEIKVRAGKSAMDATVLEIAKDGVRVQLSSGLAMIVRAEHLQF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_EHRRG
Sequence: MVDLPKFTMRDLVECGVHFGHKTSRWNPKMAPYIYGVHNDIHIINLQSTVFLLKNALSALYDIVLKRGRVLFIGTKVQASAIIADEATRCGQYYINNRWLGGMLTNWETISLSIKKLREYEKLLQNVDNQFTKKELLLFEKKRAKLDRSIGGICNMGGLPHVIFVIDTNKERIAIREANKLNIPVIAVLDTNSDPTGIDYPIPGNDDAVRSIDFFCKIISDTILEAIRSDLAKSGINVDGIKDFSVERREDFLKMNKDNKSNKSNTINADENIKESDLIGGSNNEG
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SAS4_CAEEL
Sequence: MASDENIGADGEQKPSRPFLRKGQGTARFRMPRNNKTSAGAPPTSELSSASSPSINVPRFSLSNALPNSARTVDSGISNEDETRPPTTASLPMDQPSLSSSPENRLNPAPSVAEEHGHSGQHAEEEEDNDTDEVSAMPSFVPDEPSTLVNSDHELSDDALKYKNAAAEFKAFERRMDSMRSASTITTSLATPSSCAPSNSSEPPTRSTPIMNDLGVGPNNHNWPSSMQELSGISLETPQARPLGSNRINQLVRSEAQTGISLLQHHERPTVTAPLRRNDMMNSSRQNPQNGNVQDENRPEHVYDQPIHVPGSSLDRQKLEIEIRRHRNLNIQLRDTIAHLDYAEESVHTTKRQLEEKISEVNNFKKELIEEFKKCKKGVEEEFEKKFEKIKEDYDELYEKLKRDQRDLERDQKILKKGTGERNKEFTETIATLRDKLRASETKNAQYRQDIRVRDEKLKKKDEEIEKLQKDGNRLKSTLQTLEKRVKQLRTEKERDDKEKEMFAKVAMNRKTSNPVPPVLNQSVPISITSNGPSRHPSSSSLTTFRKPSTSNRERGVSWADEPNEQSLEAVPQEFLMMPVKEMPGKFGKCTIYRDSLGETSKVTDTIANGLLFEYSNGDLRWVNRQNAVNIYISAVDKTVRIDLPTYNISIIHTFQRQVEVLRPGNNITLISIKRREVRTDLIYQNGMYKTEIFNRDGRYVTKDFSNQEVSRKYNPGTHTYRDNQCRYVLVTDYNDFELVEPEFRLRWYQGDPTGLNNQYILKIIGRPECSEKTLRLEVNLSTCEGTLETAEMIGDKRRKTTLFQWKK
What is the function of this protein?
Required for centrosome duplication.  Plays a central role in determining centrosome size.
What are the official names of this protein?
Spindle assembly abnormal protein 4.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome throughout the cell cycle. Localizes to a tiny dot in the center of centrosome. Recruited to the centrosome once per cell cycle, at the time of organelle duplication and remains stably associated after.
Protein: RL10_STRPG
Sequence: MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRRSLRESGVEFKVIKNSILTRAAEKAGLDELKDVFVGPSAVAFSNEDVIAPAKVINDFTKTADALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAENKEGAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: HIS5_WOLSU
Sequence: MVGIVNYNIGNLASVLNALVKVGAKAQIEKEPSRLLEYDRLILPGVGAFGDAMEHLVQSGMKEAVLEFAKSGKPLLGICLGMQLLFEKSYEFGEHAGLGLLEGEIIPFDKTRMGEGYKIPQMGWNRFYAKKKSPLLKGLEEGFYLYYVHSFHAVAKREEDVLGESVYGYPFVSAIERDNVAGFQPHPEKSHDVGLRILKNFCEIG
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOMA_ODOAR
Sequence: MDRAILLLSVVCLVVSSQPIADSQRLFSIAVSRVQHLHLLAQRLFSDFESSLQTEEQRQLNKIFLQDFCNSDYIISPIDKHETQRSSVLKLLSISYGLVESWEFPSRFLSGGSAPRTQISPKLSELKTGILLLIRANQDPAEIFSDPSAPQVPSYGNYYQSLGADESLRRTYELLACFKKDMHKVETYLTVAKCRLSPEANCTL
What is the function of this protein?
Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes.  Implicated as an osmoregulatory substance important for seawater adaptation.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYD_STAA3
Sequence: MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEALKIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENVNVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGARDYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDIEMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELIDVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVKVVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELGLIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIVLNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDRLVMLLTNRTNLRDTIAFPKTASATCLLTNAPGEVSDKQLEELSLRIRH
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXI_RHIME
Sequence: MSCCASSAAIMVAEGGQASPASEELWLASRDLGGGLRQTELSVPNAYCGTCIATIEGALRAKPEVERARVNLSSRRVSIVWKEEVGGRRTNPCDFLHAIAERGYQTHLFSPGEEEGDDLLKQLILAVAVSGFAATNIMLLSVSVWSGADAATRDLFHWISALIAGPALIYAGRFFYKSAWNAIRHGRTNMDVPIALAVSLSYGMSLHETIGHGEHAWFDASVTLLFFLLIGRTLDHMMRGRARTAISGLARLSPRGATVVHPDGSREYRAVDEINPGDRLIVAAGERVPVDGRVLSGTSDLDRSVVNGESSPTVVTTGDTVQAGTLNLTGPLTLEATAAARDSFIAEIIGLMEAAEGGRARYRRIADRAARYYSPAVHLLALLTFVGWMLVEGDVRHAMLVAVAVLIITCPCALGLAVPVVQVVAAGRLFQGGVMVKDGSAMERLAEIDTVLLDKTGTLTIGKPRLVNAHEISPGRLATAAAIAVHSRHPIAVAIQNSAGAASPIAGDIREIPGAGIEVKTEDGVYRLGSRDFAVGGSGPDGRQSEAILSLDFRELACFRFEDQPRPASRESIEALGRLGIATGILSGDRAPVVAALASSLGISNWYAELSPREKVQVCAAAAEAGHKALVVGDGINDAPVLRAAHVSMAPATAADVGRQAADFVFMHERLSAVPFAIETSRHAGQLIRQNFALAIGYNVIAVPIAILGYATPLVAAVAMSSSSLVVVFNALRLKRSLAAGRGATPGTLIHSGAVTS
What is the function of this protein?
FixI is a pump of a specific cation involved in symbiotic nitrogen fixation.  The four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG.
What are the official names of this protein?
Nitrogen fixation protein FixI, E1-E2 type cation ATPase FixI.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CENPM_MOUSE
Sequence: MSVLRSMDKLPDLNRATVLLVSTEDALLQQLAESMLKDDCASELRVHLANSLPLPSNVNRPRIDLIVFVINLHSKYSLQKVEEFLQHVDSSFFLGKVCFLVTGAGQESHCSVHQNTVIKLAHTYRSPLLLCDLQVESFRAAMARRLVRILQICAGHVPGVSALNLMSLLRSPENPPSKEL
What is the function of this protein?
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity).
What are the official names of this protein?
Centromere protein M, CENP-M, Proliferation-associated nuclear element protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells. Localizes in the kinetochore domain of centromeres (By similarity).
Protein: YHGN_ECOLI
Sequence: MNEIISAAVLLILIMDPLGNLPIFMSVLKHTEPKRRRAIMVRELLIALLVMLVFLFAGEKILAFLSLRAETVSISGGIILFLIAIKMIFPSASGNSSGLPAGEEPFIVPLAIPLVAGPTILATLMLLSHQYPNQMGHLVIALLLAWGGTFVILLQSSLFLRLLGEKGVNALERLMGLILVMMATQMFLDGIRMWMKG
What are the official names of this protein?
UPF0056 inner membrane protein YhgN.
What is the protein family that this protein belongs to?
Belongs to the UPF0056 (MarC) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TOP1_STAES
Sequence: MADNLVIVESPAKAKTIEKYLGKRYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKDLKKHAKKAKKIFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKDSFKHPRGIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSKFTAKFLHYKNKPYKLNNKDDVQRITEALNGDQFEITNVNRKEKTRYPAHPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISTSAKSEAQQYINDKYGEQYVSQRKSSGKQGDQDAHEAIRPTSTMRTPDDMKAFLTRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNDIKFRANGQTIKFKGFMTLYVEAKDDKENDKENKLPQLDKGDKVTATKIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFIPTELGEIVYEQVKEYFPEIIDVEFTVNMETLLDKIAEGDMNWRKVIGDFYNSFKQDVERAESEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCNEGDVVERKSKKNRIFYGCSRYPECDFISWDKPVGRDCPKCHHYLVNKKKGKSSQVVCSNCDYEEEVQK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: DMGD_MUSP7
Sequence: MSKLKITNVKTILTAPGGIDLAVVKVETNEPGLYGLGCATFTQRIFAVKSAIDEYMAPFLIGKDPTRIEDIWQSAAVSGYWRNGPIMNNALSGVDMALWDIKGKLAGMPVYELLGGKCRDGIPLYCHTDGGDEVEVEDNIRARMEEGYQYVRCQMGMYGGAGTDDLKLIATQLARAKNIQPKRSPRSKTPGIYFDPEAYAKSVPRLFEHLRNKLGFGIEFIHDVHERVTPVTAIQLAKTLEPYQLFYLEDPVAPENIDWLRMLRQQSSTPISMGELFVNINEWKPLIDNKLIDYIRCHVSTIGGITPAKKLAVYSELNGVRTAWHGPGDISPVGVCANMHLDMSSPNFGIQEYTPMNDALREVFPGCPEIDQGYAYVNDKPGLGIDINETLAEKYPCDGGIPSWTMARTPDGTASRP
What is the function of this protein?
Has low dehydratase activity with D-mannonate and D-gluconate, suggesting that these are not physiological substrates and that it has no significant role in the in vivo degradation of these compounds.  Has no detectable activity with a panel of 70 other acid sugars (in vitro).
What are the official names of this protein?
D-galactonate dehydratase family member Dd703_0947, D-gluconate dehydratase, D-mannonate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: RF3_DESVH
Sequence: MSTRLEREVARRRTFAIISHPDAGKTTLTEKLLLFGGAIQMAGAVKARKSGRHATSDWMAMERERGISVTTSVMQFPYGDHMVNLLDTPGHQDFSEDTYRVLTAVDSALVVIDVAKGVEAQTRKLMDVCRLRDTPVMTFINKLDRDGLPPLDVMADIEENLRIECVPLTWPIGMGSDFKGTYNLLKRELHLFSASHHGRIQEGILIRDLDDPLLDEHLGPQADALRMDLALLEEAGTPFSREKYLRGEQTPVFFGSAINNFGVRELLDNFVDLAPAPRPRPAITREVSPHEESFTGVVFKIQANMDKAHRDRMAFMRICSGTFTRGMKLRHHRVGKDVTVANATIFLAQDRSGVEEAFPGDIIGIPNHGTIKIGDTFTESKEELKFTGIPSFSPEHFRRVRLRNPLKAKQLQKGLEQLAEEGAVQLFRPQVNNDYILGAVGVLQFDVIISRLHDEYSVEAAYEPCSIHTARWLHCNDRKVFAEFCDYYSAELAIDAEGALAYLAPNPWRLESAMERYPAVEFRTTREIR
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBL_ACIB4
Sequence: MVRVMATGVFDILHPGHVLFLREARKLGDELVVVVARDSTVERLKHKPIMNEDIRRFMVESLKPVDRAVLGHKDDMYKTVEDVRPDIIVLGYDQKFDEKEIEEECRKRGIKVKVVRLKKYGDSDLNGTRKIIFKIVDRVDDLYAKDRNS
What is the function of this protein?
Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
What are the official names of this protein?
FAD synthase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase.
What is the protein family that this protein belongs to?
Belongs to the archaeal FAD synthase family.
Protein: Y1161_HAEIN
Sequence: MLWKKTFTLENLNQLCSNSAVSHLGIEISAFGEDWIEATMPVDHRTMQPFGVLHGGVSVALAETIGSLAGSLCLEEGKTVVGLDINANHLRPVRSGKVTARATPINLGRNIQVWQIDIRTEENKLCCVSRLTLSVINL
What are the official names of this protein?
Putative esterase HI_1161.
What is the protein family that this protein belongs to?
Belongs to the thioesterase PaaI family.
Protein: ADH7_YEAST
Sequence: MLYPEKFQGIGISNAKDWKHPKLVSFDPKPFGDHDVDVEIEACGICGSDFHIAVGNWGPVPENQILGHEIIGRVVKVGSKCHTGVKIGDRVGVGAQALACFECERCKSDNEQYCTNDHVLTMWTPYKDGYISQGGFASHVRLHEHFAIQIPENIPSPLAAPLLCGGITVFSPLLRNGCGPGKRVGIVGIGGIGHMGILLAKAMGAEVYAFSRGHSKREDSMKLGADHYIAMLEDKGWTEQYSNALDLLVVCSSSLSKVNFDSIVKIMKIGGSIVSIAAPEVNEKLVLKPLGLMGVSISSSAIGSRKEIEQLLKLVSEKNVKIWVEKLPISEEGVSHAFTRMESGDVKYRFTLVDYDKKFHK
What is the function of this protein?
NADP-dependent alcohol dehydrogenase with a broad substrate specificity.  The oxidative reactions are more than 100 times less efficient than the corresponding reductions, suggesting that the enzyme acts as an aldehyde reductase, rather than as an alcohol dehydrogenase.
What are the official names of this protein?
NADP-dependent alcohol dehydrogenase 7, NADP-dependent alcohol dehydrogenase VII, ADHVII.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: RLMF_YERPE
Sequence: MLSYAPENAYQRASTMENKKVFPKEKSGLHPRNRHCSRYDFDALSVSCPELIPFLAPTAYGDISVDFADPLAVKMLNKALLKHFYGIEYWDIPADSLCPPIPGRADYVHHLADLLASCNGEVIPKGKNIALLDIGVGANCIYPIIGQREYGWRFTGTDIDSHALSAAKMVVSMNPTLKNTLRLKQQKDPHAIFEGVWAVNERYDATLCNPPFHGSAEEAAATTRRKLHKLGKNEVAAKPVQNFGGKNSELWCEGGEEGFVSRMVAESVAKAQNCFWFTSLISKKTTLPAIYHALRYVKAVEVRTIEMAQGQKVSRFVAWTFLTPEQQAAWVAERWA
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPS10_COPC7
Sequence: MAGLTTAFGGRLILWFLVLWISITAAQKPEHAISSFDNPPARVFFFDDTLSVIYHDRISGNLYVSQDEGKSWKKAEGIPERSVSVVIEHPYDTRLAFALTEGTKHYRTEDRGKTWRPFTIPDSPAVVARPLSFHSDPKKWRYVIYQGTKCEGIVCYDVAYYSKDAFSDEPKLMLTDVNRCQFAHSNKDFKHDAHPDLIFCVASDQRTVTGAHNLASQRLYSSTDFFDKDKKVEDLGIGKNARGVVAFAIVSRFGVVALKDLSRSDGEMQLYVTTDAKNWAKGHFPHASSARLRENAYTIVESTTHSLGVDVVLKDRSTIGTLFLSNSNGTYFVESLKDTNRNEQGFVDYERVYGVDGVGLANVVANAQEVEGRNAPKKLRSMITFDDGRRWQPLRAPPRDDEGNRINCDPSDSEKCALHLHSVTTPHNYGRIFSSPAPGLVMGVGTVGPHLGSYEDSDTFLSTDAGLTWKMVTKEAHQYEFGDQGSILVVVNNEDWTSEIKYSLNLGKTWQTYDFGIKIRSRGLITLPDSTSQKFLLLGLTSRQDQEKDMRLGKVVVIYLDFAKTRKNKCTEKDFDKWYARPTGKRECIMGHKQWYKRRKVDADCYVGEKFIDPEGHEENCECTEEDYEWSVVVYFFVYFTDAPSLSDYNFVRNGDKCEPAGPEPVPPGVCTKNDPTEKYMGSSGFRKIPGNTCVGGKKLDQPVEKYCSKARPAEGSVIHTKFQFDSPIVQFAYFPESTTILVRLLDESIWQSSNEGYTWSQLFKNERFVAFYHHKYSNERAYLITRTKKFYYTTDTGRSWNTMTAPNPPNTFDARVLRFSPSDTDFLIWTGNADCERGKTNCHAEAHFSRKNGRGWTLIDKYVRNCAFAEDKDLSADPSDIICESVKEKKGMQVKGARMELVAGSGYYQGRKRVLFENVVGFAKFSEFLVVAGLQPETKSLELQVSLDGTHFASGKFPPSMSPNTHAYTVLESTTNALFIHMTMTTAPPPAPQWGTLLKSNSNGTYFGVSIENVNRNERGYVDFEKMIGLDGIALVNVVQNVDVLAEGGGVRKGGLGMGSGTTTRQVGELKKLQTRITHNDGSTWRPLTPPVVDSLGNKYECEGTQCALHIHGYTARRDPRATYSSPAAVGVMMAVGNVGTHLAPYGDSDTFISRDGGFTWEEVHKDAHMWEYGDSGSIIIIVNDEEPTDHLMFTTDEGLTWKEYRFSEEKVRVMAVTNVPSDRSRRFLLFGTQEGRKGGSVAIHVDFTELTSRQCLLNEQNPGNDDFELWSPSEDRVELCLFGRQTLYHRRVRDAQCYIGNQPKVEAKIQRNCTCTRVDFECEFNYIKNDKDECVLVPGTTPLPNDDSVCKKGEEYWYERTPYRLIPYSSCEGGTRLDRGTAHRCPGVKSKSGWFWMVMLVLPFGFTALVGYWYYRRSGMARGTIRLPGGDNRAPGSTFGSGSGVLDTLASVPWFLVGMAGIAMDWLSSKLDEGISRSRRGYRNVPIDEDAQILRFEDED
What is the function of this protein?
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.  Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
What are the official names of this protein?
Vacuolar protein sorting/targeting protein 10, Carboxypeptidase Y receptor, CPY receptor, Sortilin VPS10, Vacuolar carboxypeptidase sorting receptor VPS10.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Prevacuolar compartment membrane; Single-pass type I membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Protein: HMGB2_PIG
Sequence: MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKGEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEDEDEEEEDEDEE
What is the function of this protein?
Multifunctional protein with various roles in different cellular compartments.  May act in a redox sensitive manner.  In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity).  Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA.  Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11275566).  Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).  Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors.  In the extracellular compartment acts as a chemokine.  Promotes proliferation and migration of endothelial cells implicating AGER/RAGE.  Has antimicrobial activity in gastrointestinal epithelial tissues.  Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity.  May play a role in germ cell differentiation.  Involved in modulation of neurogenesis probably by regulation of neural stem proliferation.  Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
What are the official names of this protein?
High mobility group protein B2, High mobility group protein 2, HMG-2.
What is the protein family that this protein belongs to?
Belongs to the HMGB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Secreted.
Protein: ISPE_CORGB
Sequence: MKITAKAWAKTNLHLGVGPARDDGFHELMTVFQTIDLFDTVTLTTLDEELVEEGSVVKQLSVTGARGVPEDASNLAWRAVDALVKRRAEKTPLSAVSLHISKGIPVAGGMAGGSADAAATLRAVDAWIGPFGEDTLLEVAAELGSDVPFCLLGGTMRGTGRGEQLVDMLTRGKLHWVVAAMAHGLSTPEVFKKHDELNPESHMDISDLSAALLTGNTAEVGRWLHNDLTSAALSLRPELRSVLQEGIRSGAHAGIVSGSGPTTVFLCESEHKAQDVKEALIDAGQVYAAYTATGPAASTADQRGAHILTVSQ
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PETL_NANDO
Sequence: MLTITSYFGFLLAALTITSVLFIGLNKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.