PharMolix/UniProtQA huggingface dataset:
Protein: NR5A2_HUMAN
Sequence: MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
What is the function of this protein?
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis.  Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism.  Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).  Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation.  May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors.  Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver.  May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.  Activates the transcription of CYP2C38 (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 5 group A member 2, Alpha-1-fetoprotein transcription factor, B1-binding factor, hB1F, CYP7A promoter-binding factor, Hepatocytic transcription factor, Liver receptor homolog 1, LRH-1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TPST2_HUMAN
Sequence: MRLSVRRVLLAAGCALVLVLAVQLGQQVLECRAVLAGLRSPRGAMRPEQEELVMVGTNHVEYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGREKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRLFPNSKFLLMVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGKEKCLPVYYEQLVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSKWTGHIPGDVVRDMAQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGDYKTPANLKGYFQVNQNSTSSHLGSS
What is the function of this protein?
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
What are the official names of this protein?
Protein-tyrosine sulfotransferase 2, Tyrosylprotein sulfotransferase 2, TPST-2.
What is the protein family that this protein belongs to?
Belongs to the protein sulfotransferase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: HMDH_PYRHO
Sequence: MGGGNLNIEEIIEKVANGEIKFYQVEKYVNGDKRLATEIRRKALEKRLGIKLHHIGYYSIDPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTLIDDKMTRAPLIRCPNARRAREVAKWVEENLDYLQEKAVSKVTRHGKLRGVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVIAEAVVPRKIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFANIVGAIFLATGQDEAQITEGAHGITIAEVTPDGDLYISITMPSLEIGTVGGGTRVPSQREALEIMGVAGGGDPPGINAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR
What is the function of this protein?
Converts HMG-CoA to mevalonate.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
Protein: BARW_HORVU
Sequence: QQANDVRATYHYYRPAQNNWDLGAPAVSAYCATWDASKPLSWRSKYGWTAFCGPAGPRGQAACGKCLRVTNPATGAQITARIVDQCANGGLDLDWDTVFTKIDTNGIGYQQGHLNVNYQFVDCRD
What is the function of this protein?
May be involved in a defense mechanism.  Probable plant lectin.  Binds weakly a chitin analog.
What are the official names of this protein?
Barwin.
Protein: CYNS_CRYNB
Sequence: MFNLPYHCKALLTAKQERGLTFDDVAKAINKPEVWTTALFYGQASTDKSTAEAILKALGGEQFWTDYNDRLEAGQEKIDIRRVLNGLSGNGEENMGVKGMVTRGATFEVPPKDPVLYRLYEVLVVYGYSYKALIYEKFGDGIMSAIDFRTSLERKKDPKGDRVVITMDGKFLPYSDPSAWGTQ
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: RFCL_METM7
Sequence: MEEWVEKYRPKSLNDVAGHNKTKESLIEWIESFINGQKQKPILLAGPPGSGKTTLAYAIAKDYAFDVIELNASDKRNKDVISQVVGTAATSKSLTGKRTLIVLDEVDGLSGNDDRGGVAEIIKVLKTAENPVILTANDVYKPALMTLRNSVNLINVGSVHTNSIPPVLRKIALKEGFEIDEKVIKTIASHAGGDLRAAINDLQSLATGGSIEVEDAKELPDRDSEKSIFDAMRIIMKTTHYDIATSATRDVKEELGTIEEWISENLPKEYLKYKDLANGYDYLSKSDVFLGRVFRRQYFGLWRYASALMTAGTALAKEEKYRGFTRYAPPAIFTKLSRTKGSRQRMKDILKKIALKTHTSTKRARNTLDYMVVVFESNEAVSAELVEYYELTKEEIEFLTNKTIAKNIFSVIAGKKPKVEKETPKKKKKAEDVVPIIPKRPKISEPPKEPLKEVIEETVEKTDKKEKEKKDPKKQATLDSFF
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C large subunit, RFC large subunit, Clamp loader large subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcL subfamily.
Protein: ULAF_ECO55
Sequence: MQKLKQQVFEANMDLPRYGLVTFTWGNVSAIDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVEGEYRPSSDTATHLELYRRYPSLGGIVHTHSTHATAWAQAGLAIPALGTTHADYFFGDIPCTRGLSEEEVQGEYELNTGKVIIETLGNAEPLHTPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMAWIARSINPQLNHIDSFLMNKHFMRKHGPNAYYGQK
What is the function of this protein?
Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 4-epimerase UlaF, L-ascorbate utilization protein F, Phosphoribulose isomerase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: SRA18_CAEEL
Sequence: MNKTAEELDSRNCASESLTNALISITMKFNFIFIITVVLISYCFTWLAIQALWKHNIFSNSTRLILIVCLLNSVVHQTTMLETRITQAYRSVVYDSEPCKLLFRSSDCVFELYLYYPTGYFSTYSVFSLTFDRLISHYKSRYYHMHQYFIATSLLVLQLLLTMFSFYIVFYGVSLAGYVPMCNFRPELTVYYGAINNVRTGVMVSCIIVTMFVYYVCVKSEKQIQKCSYSPGERYSAYENVTTSQSICISIVLQFSCIMISSFGSNLLIHITSKTTVSEEVFYAIVSFLPGVTYANLCLPLVIYFKTKLTTRNRKNRIAVMTSMYGDAGEHIDRLKRSWE
What are the official names of this protein?
Serpentine receptor class alpha-18, Protein sra-18.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein sra family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS4_ECO8A
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIEQAPGQHGARKPRLSDYGVQLREKQKVRRIYGVLERQFRNYYKEAARLKGNTGENLLALLEGRLDNVVYRMGFGATRAEARQLVSHKAIMVNGRVVNIASYQVSPNDVVSIREKAKKQSRVKAALELAEQREKPTWLEVDAGKMEGTFKRKPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RS18_BOVIN
Sequence: MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
40S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_CLOB6
Sequence: MVKGIFITATGTDIGKTYITALIVKKLREFNINCGYYKAALSGAERIDGKLIAGDANYVYNIADIKGDPNDAVSYIFEQAVSPHLAAKLNNVEISMEKIKKDFSYIKNKHDYITVEGSGGIICPISMGKEKIMLENIIKSFKLPAIVVADAGLGTINSTILTLQYIKEKNISVKMILLNNYNHEDIIHIENKRYLSDNLPIPVYTCNKNSNNLEIPAEKLIEYYEEI
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_PROMT
Sequence: MLDHINELPDWISRGLDDLFPNDNSGDSDQSFLKRLELSSVDKKPLRVKLGIDPTGTDIHIGHSILFRKLRAFQDAGHTAILIIGDFTARIGDPTGKSKTRIQLSKDEVQSNALNYLEQLGLGKDPKDSLLDFSIPSRIEIRRNSEWLENLNLSKVIELLSNSTVGQMLAKEDFSNRYKSGTPISLHEFLYPLLQGYDSVAINSDVELGGTDQKFNIAMGRDLQKAFGQKPQFGMLLPILVGLDGARKMSKSLDNIVGINEDSLSMYSKLEKVPDDLVLTYLNLLTNENLKELSSNPREVQKFMALKVTSNFKGIEAAKNAQFNSEKLVLGTKDSLEEIPEASVSNVNFPAKAFYLFSKMEMCSSSSEARRQILGGGVRIDGKKIMDPNLEFHTPDDLIGKILQVGKKKFLRVST
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_SHEPW
Sequence: MSLSVEAKAKILAEFGRCENDTGSSEVQVALLTAQINHLQGHFKEHIHDHHSRRGLLRMVSTRRKLLAYLKRTENVRYQELIKKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SUS4_ARATH
Sequence: MANAERVITRVHSQRERLDATLVAQKNEVFALLSRVEAKGKGILQHHQIIAEFEAMPLETQKKLKGGAFFEFLRSAQEAIVLPPFVALAVRPRPGVWEYVRVNLHDLVVEELQASEYLQFKEELVDGIKNGNFTLELDFEPFNAAFPRPTLNKYIGDGVEFLNRHLSAKLFHDKESLHPLLKFLRLHSHEGKTLMLNNRIQNLNTLQHNLRKAEEYLMELKPETLYSEFEHKFQEIGLERGWGDTAERVLNMIRLLLDLLEAPDPCTLENFLGRIPMVFNVVILSPHGYFAQDNVLGYPDTGGQVVYILDQVRALETEMLQRIKQQGLNITPRILIITRLLPDAAGTTCGQRLEKVYGSQYCDILRVPFRTEKGIVRKWISRFEVWPYLETFTEDVAAEISKELQGKPDLIIGNYSDGNLVASLLAHKLGVTQCTIAHALEKTKYPDSDIYWKKLDEKYHFSCQFTADLIAMNHTDFIITSTFQEIAGSKDTVGQYESHRSFTLPGLYRVVHGIDVFDPKFNIVSPGADMSIYFAYTEEKRRLTAFHLEIEELLYSDVENEEHLCVLKDKKKPIIFTMARLDRVKNLSGLVEWYGKNTRLRELVNLVVVGGDRRKESQDNEEKAEMKKMYELIEEYKLNGQFRWISSQMNRVRNGELYRYICDTKGAFVQPALYEAFGLTVVEAMTCGLPTFATCNGGPAEIIVHGKSGFHIDPYHGDKAAESLADFFTKCKHDPSHWDQISLGGLERIQEKYTWQIYSQRLLTLTGVYGFWKHVSNLDRLESRRYLEMFYALKYRPLAQAVPLAHEE
What is the function of this protein?
Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways.
What are the official names of this protein?
Sucrose synthase 4, AtSUS4, Sucrose-UDP glucosyltransferase 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily.
Protein: CRTE_PSEVU
Sequence: MVSGSKAGVSPHREIEVMRQSIDDHLAGLLPETDSQDIVSLAMREGVMAPGKRIRPLLMLLAARDLRYQGSMPTLLDLACAVELTHTASLMLDDMPCMDNAELRRGQPTTHKKFGESVAILASVGLLSKAFGLIAATGDLPGERRAQAVNELSTAVGVQGLVLGQFRDLNDAALDRTPDAILSTNHLKTGILFSAMLQIVAIASASSPSTRETLHAFALDFGQAFQLLDDLRDDHPETGKDRNKDAGKSTLVNRLGADAARQKLREHIDSADKHLTFACPQGGAIRQFMHLWFGHHLADWSPVMKIA
What is the function of this protein?
Catalyzes the condensation of farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) to yield geranylgeranyl diphosphate (GGPP) needed for biosynthesis of carotenoids and diterpenes.
What are the official names of this protein?
Geranylgeranyl diphosphate synthase, GGPP synthase, Farnesyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: ATPB_AQUPY
Sequence: MAEVIKGRIVQVIGPVVDVEFEGVKELPRIKDGLKTIRRAIDDRGNWFEEVLFMEVAQHIGEHRVRAIAMGPTDGLVRGQEVEYLGGPIKIPVGKEVLGRIFNVAGQPIDEQGPVEAKEYWPMFRNPPELVEQSTKVEILETGIKVIDLLQPIIKGGKVGLFGGAGVGKTVLMQELIHNIARFHEGYSVVVGVGERTREGNDLWLEMKESGVLPYTVMVYGQMNEPPGVRFRVAHTGLTMAEYFRDVEGQDVLIFIDNIFRFVQAGSEVSTLLGRLPSAVGYQPTLNTDVGEVQERITSTKKGSITAIQAVYVPADDITDPAPWSIFAHLDATTVLTRRLAELGIYPAIDPLESTSKYLAPEYVGEEHYEVAMEVKRILQRYKELQEIIAILGMEELSEEDKAIVNRARRIQKFLSQPFHVAEQFTGMPGKYVKLEDTIRSFKEVLTGKYDHLPENAFYMVGTIEDAIEKAKQMGAKV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ISCS_PECCP
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFLTLDGTFGNPASRSHRFGWQAEEAVDIARNQIAELVGADPREIVFTSGATEADNLAIKGVANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLAELEAAMREDTILVSIMHVNNEIGVVQDIETIGEMCRSRGIVFHVDATQSVGKLPIDLNQLKVDLMSFSGHKIYGPKGIGALYVRRKPRIRLEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMTAEMDRLRTLRDRLWNGINDIEEVYLNGDIEQGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGMNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRLRDLSPLWEMFKQGVDISSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_ACTP7
Sequence: MNLNATLIGQLIAFALFVAFCMKFVWPPLIKAIEERQANIANALASAEKAKQEQADSKAAADQEILKAKEEAQKIIDLATKRRNEILESVQAEAEIERQRIIEQGHAEVESERKRVQEELRQKVAALAVAGAEKIVGRSVDQAANNDIIDKLVAEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PRA13_HUMAN
Sequence: MSIQAPPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFMEAFRRRHFQTLTVMVQAWPFTCLPLGSLMKTLHLETLKALLEGLHMLLTQKDRPRRRKLQVLDLRDVDENFWARWPGAWALSCFPETMSKRQTAEDRPRMGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHLCCSKLVNYLTPIKHLRKSLKIIYLNSIQELEIHNMSWPRLIRKLRCYLKEMKTLGKLVFSRCHHSTSDNELEGRLVTKFSSVFLGLEHLQLLKIKLITFFSGHLEQLIRCLQNPLENLELTYGYLLEEDVKCLSQYPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLETLILEGCQIHYSQLSAILPGLSRCSQLTTFYFGRNCMSMGALKDLLRHTSGLSKLSLETYPAPEESLNSLVRVNWEIFTPLRAELMCTLREVRQPKRIFIGPTPCPSCGSSLSEELELHLCC
What are the official names of this protein?
Putative PRAME family member 13.
What is the protein family that this protein belongs to?
Belongs to the PRAME family.
Protein: SYI_SULIA
Sequence: MKPLTGNYDPKKIEDEIISFWEENKIYNKLRDIVSKRREKFLFIDGPPYPSSPTPHIGTIWNKVIKDCILRYERLLGKKVHDQPGYDTHGLPIEVATERLLGILNKQEIIDKIGVENFINKCKEFALSNATKMTQNFKDVGVFMDWERPYYTLDPSYISSSWSVIKKAYEKGMLDKGTAVLHWCPRCETTLSDYEVSEYRDLEDPSIYVKFKIKGEENRYLLIWTTTPWTIPSNVFVMVNKDYDYADVEVNGEVLVLAKDRIEAVMKEASITNYKVLRTYKGSELIGVKYKHPLRDFVSAQTKLDDFHQVVDAGNVVTLTDGTGLVHAATGHGEEDFLIGQKYGFPVVMFVNDRGEFTEEGGKYKGLKVRDASKVIINDLKSKNALFFEGKIVHRYPVCWRCKTPLVLRAIDQWFIRVTKIKDEMLKEIENVNWIPDWGKSRISNMVKELRDWVISRQRFWGTPLPIWICEKCNNVIVVGSREDLESIAIDSVPNDLHRPWIDNVRVKCNKCGGVAKRIADVADVWFDSGVAFFASLGKDWQEKWKELGPVDLVLEGHDQLRGWFFSLLRSGLILLDKAPYVSVLVHGFMLDEQGREMHKSLGNYVEPSVVIQRYGRDILRLWLLRNTTWEDARFSWRALELTKRDLQIIWNTYVFASMYMNLDNFEPVKYTLDDVIKYAKIEDLWILSRFNSMLKKVNESMKNYKVHEMANYLINFLVEDVSRFYIRLIRKRAWIEANTQDKIAMYYILYFILKQWIILASTIIPFISEKIYKSFVVNPKESVSMESSINYDERFIDNELERAFEVAREINEASLNARAKAGIKLRWPLAKVYIFVEDEDTLAKVNRIKDVLLSLLNAKDIEISKIEGFKSFSKYKVEPNRSIIGKEYKSMSPKILDYIRNNSDIIAIDILNKKQHVARIDNVDVILNTSHVIISEETIEGYVSSKFAQGIVVISKEISESEEEEGLVRDIIRRIQFMRKQLKLNVVDYIEISIKAPEERVKTIQKWEEFIKSETRGNKVILGDPKGDIVMDWDIEGESYIIGIKKST
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_RHILO
Sequence: MSRTLVLVRHGQSEWNLKNLFTGWRDVDLTEQGHAEAKAAGQKLKARGLKFDIAFTSALSRAQKTCQHILDAVGQSDLKTIRDQALNERDYGDLSGLNKDDARKKWGEEQVHVWRRSYDVSPPGGESLKDTGARVWPYYLHDLQPHVLRGGTVLVAAHGNSLRALIMALDGKSGEEIVKLELGTGVPVIYQLNADSTVASKEVLEG
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: MEP2_TRIEQ
Sequence: MHGLLLAGLAAALPLGVAGLPARQQSGLSPRGIDINPYRFASMAKYSEHKATSQMVHSFSYSKDDDYVATATKLVKSTFPNMTFRTVKDHYIGTNGIGHVHFKQTAHGIDIDNADFNVNIGRDGKVFTFGNSFYEGEMPKTNPLTKRDFADPVKALHGAIKTLKLPVKPQSAKAMPMKEAETFMFEGTSGALSEPMAKLVYIQKDGKLHLTWRVETDVGDNWLLSYVDSKETETVHNVVDYVASADYKVFAWGLNDPTEGQPTMIKDPWNTTGSGSPFTWHGDGEMDYTVTRGNNIAAQDNPSGGGQWENNYRPESPELSFVYEYNEQMEPEQYKDFAITQLFYTTNTFHDLLYSFGFTEEAGNFQMNNNGKGGEGNDFAICNAQDGSGTNNANFATPPDGQNGRMRMYTWTTAQPSRDGDLEAGIVIHEYAHGLSNRLCGGPANSNCLSELEAGGMGEGWGDFYATAIRLKQDDTRETDYTMGEWAANMEGGIREYPYFTNMQTNPYTYDDVEGMSEVHGIGTVWATILYDVLWNLIDEHGMSKNIMPKFVNGAPSDGRNLAMKLVLDGMTLMPCNPNFVQARDAIIDADQALTNGQNKCALMKAFSK
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 2, Fungalysin MEP2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMD_SALTO
Sequence: MRVDVVSIFPEYFAPLDLSLIGRARASGTLQLAVHDLRTWTHDVHRTVDDTPYGGGPGMVMRPEPWGEALEALAPPGGNPPRLLVPTPAGAPFTQALAHELAAEPHLLFACGRYEGIDQRVLEHAASRMPVTEVSLGDYVLFGGEVAVLVILEAVTRLLPGVLGNVGSLDDESHAHGLLEAPMYTKPAVWRGQEVPTVLRSGDHGKIARWRRDEALARTVARRPDMIAALPPECLDPRDRAALERAGFPDPPEGVAK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRPRA_CANLF
Sequence: MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREREESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNSKKKGAKKESSDGPLATGKAVPAEKSGLPAGPENGVELSKEELIRRKREEFIQKHGRGLEKSSKSTKSDAPKEKGKKAPRVWALGGCANKEVLDYSAPTTNGAPDAAPPEDINLIRGTGPGGQLQDLDCSSSDDEETAQNASKPSATKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRHQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEHVRTHTRRLSALHPPEKHAGPTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA
What is the function of this protein?
Component of the SRP (signal recognition particle) receptor (By similarity).  Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity).  Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity).  SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
What are the official names of this protein?
Signal recognition particle receptor subunit alpha, SR-alpha, Docking protein alpha, DP-alpha.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.
Protein: CDY1_HUMAN
Sequence: MASQEFEVEAIVDKRQDKNGNTQYLVRWKGYDKQDDTWEPEQHLMNCEKCVHDFNRRQTEKQKKLTWTTTSRIFSNNARRRTSRSTKANYSKNSPKTPVTDKHHRSKNRKLFAASKNVRRKAASILSDTKNMEIINSTIETLAPDSPFDHKTVSGFQKLEKLDPIAADQQDTVVFKVTEGKLLRDPLSRPGAEQTGIQNKTQIHPLMSQMSGSVTASMATGSATRKGIVVLIDPLAANGTTDMHTSVPRVKGGQRNITDDSRDQPFIKKMHFTIRLTESASTYRDIVVKKEDGFTQIVLSTRSTEKNALNTEVIKEIVNALNSAAADDSKLVLFSAAGSVFCCGLDFGYFVKHLRNNRNTASLEMVDTIKNFVNTFIQFKKPIVVSVNGPAIGLGASILPLCDLVWANEKAWFQTPYTTFGQSPDGCSSITFPKMMGKASANEMLIAGRKLTAREACAKGLVSQVFLTGTFTQEVMIQIKELASYNPIVLEECKALVRCNIKLELEQANERECEVLRKIWSSAQGIESMLKYVENKIDEF
What is the function of this protein?
Has histone acetyltransferase activity, with a preference for histone H4.
What are the official names of this protein?
Testis-specific chromodomain protein Y 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: ESPB_MYCSE
Sequence: MSEELKYELPGLERKAHECESTRPEGPGDATKPDELATTASVYGKLMASAAKLKATFAAGDREGKRIAAAIRAAAGAYQKIEEQKAAELNRQMNGSDAPPPAAEAVVPDMSGIPGPLTIPSMEYPSAAAAADEMDWEAAARIIHSGDTQALSMKYFRDQWRDYQSTLEGHGRHFANPAEGWSGAAAETCAEAQRRLSTWWADMGAECGRLAQEATTFVDAHDKLVANHPTMDDVKAFEEAEWESEWDRQYAWAIKQEKSEDALEAYANGSQIQEIRPGKPPSIGGLPAVNDGDVQATPTSTTGGPGGPGSGSGGGSGGGASGGSGGGTPEMPELPSTDPSMSPMSTNSAGEEQSSGSPSSGGSSSGGSPSGGSPSGGGAPSSGGMPEGGLPTDMPGGPDIPGLDDPSLKPASAGGGGGGGVGGGGGGGMPAAPLGPAVGADSVSPSPSSTRGGGVGVPTGTGGGAGGMMGGGMGGMGAGHGQGQGKEKKRDPKLAPDEDLYTEDRAHSEGVIGHRPRREKDSGKQQ
What is the function of this protein?
Involved in DNA conjugation, at least in the recipient strain (PubMed:18554329).
What are the official names of this protein?
ESX-1 secretion-associated protein EspB, Antigen MTB48.
What is the protein family that this protein belongs to?
Belongs to the EspB family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the ESX-1 / type VII secretion system (T7SS) (By similarity).