PharMolix/UniProtQA huggingface dataset:
Protein: TSGA_CITK8
Sequence: MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKTQLRFGFVLMVLAVAGLMLSHSLALFSAAMFVLGLVSGITMSIGTFLITQMYEGRQRGSRLLFTDSFFSMAGMIFPMVAAYLLARSIEWYWVYACIGLVYVAIFILTFGCEFPALGKHAPKTETPVVKEKWGIGVLFLSIAALCYILGQLGFISWVPEYAKGLGMSLNDAGTLVSDFWMSYMFGMWAFSFILRFFDLQRILTVLAGLAAVLMYLFIKAQPEHMAWFILTLGFFSSAIYTSIITLGSQQTKVPSPKLVNFVLTCGTIGTMLTFVVTGPIVAHSGPQAALLTANGLYAVVFVMCFILGFVTRHRQHNVPAAH
What are the official names of this protein?
Protein TsgA homolog.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAA_CAMC5
Sequence: MLADEVLELLSAEISPNEYEYYIKQLKFNEKASSDETVVFNAPNELIAKFIKTKYATKIAHLFEVKTGTKPNVEITTQTKLKSSKQNQVNIKQIKAQSTLLNPAYTFENFVVGGSNEYAFLSAKAASEQPGKIYNPLFIYGPTGLGKTHLLQSVGNFCLNQGKVVICVTSEQFMTDFTYNINNHSMERFREKYRNCDVLLIDDVQFLGKTDKIQEEFFHTFNELHSKNGQIVMTSDRQPKLLKGFEDRLRTRFEWGIMADITPPELDTKIAIIQKKCEFDKIYLNKDVINYIATNMGDNIREIESAIINLNAYANLMRQEITLDFAKNVMRDLIKEKRENINLENIIEVVSKELNIKPSDIKSKSRVQNIVEARRIVIYLAKMLTTNSMPQIANYFSMKDHSAVSHNIKKINELIENNEIFNLRVSELKNKILTKG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_ECOLI
Sequence: MAVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITTRHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSK
What is the function of this protein?
In the E. coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G.
What are the official names of this protein?
50S ribosomal protein L2, Large ribosomal subunit protein uL2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: TRPA_SACS2
Sequence: MEMGKMLVVYMTLGYPNVQSFKDFIIGAVENGADILELGIPPKYAKYDGPVIRKSYDKVKGLDIWPLIEDIRKDVGVPIIALTYLEDWVDQLENFLNMIKDVKLDGILFPDLLIDYIDDLDKIDGIIKNKGLKNVIFTSPSVPDLLIHKVSKISDLFLYYGVRPTTGVPIPVSVKQLINRVRNLVENKLIVGFGLSSESDLRDALSAGADGIAIGTVFIEEIERNGVKSAINLVKKFRAILDEYK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: UNG_CHLTR
Sequence: MHEAFTIEQLPPSWQEQLKDEWSQPYWSQLLAFLKSEYAQATIYPKKENVFAALQSTPFDQVRVVILGQDPYHGEGQAHGLSFSVPRGQALPPSLRNIFQELHTDLGIRNESGCLQAWADQGVLLLNTVLTVRAGEAFSHAGRGWERFTDAIVTKLIQNRTHVIFVLWGNAARQKCNLLFQTKHQHAVLACPHPSPLAAHRGFFGCCHFSKINYLLKKQGKTMINWKIE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FSP1_TAEGU
Sequence: MGSRLSLDGSVRVVVVGGGFGGTAAASLLKSWAVPFVLVDVRDAFHHNVAALRAAVESGFAKKTFISYSVTFGDSFRQGKVVAIDPGRQQVVLSDGEELHYSHLILATGSDGPFPGKFNQVIDMESAIQTYEDMVKEIEKSQRILVVGGGAAGVEMAAEIKTEYPGKEIILIHSKTALADVELLPSVRQVVKEILLRKGVRLLLSEKVSDIENLRPNQFQKDMVVRTEKGTEVVVDMVVLCTGIKINSSAYAAAFGDKMASDGALKVNKHLQLEGYENIYAIGDCADLKEPKMAYHAGLHANVVVTNIINSLTQKPLKTYEPGSLTFLLSMGRNDGVGQVNGYYVGRLLVTIAKSRDLFVSKSWRTMGQTMPS
What is the function of this protein?
A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis.  At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis.  Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis.  This anti-ferroptotic function is independent of cellular glutathione levels.  Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms.  Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis.  May play a role in mitochondrial stress signaling.  Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death.
What are the official names of this protein?
Ferroptosis suppressor protein 1, FSP1, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, AMID, p53-responsive gene 3 protein.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Lipid droplet. Cell membrane; Lipid-anchor. Cytoplasm. Mitochondrion membrane. Nucleus.
Protein: GLND_RHILV
Sequence: MRDLDFTNILDVELLQKQCDAVAEANRNRPDVLRADLLAVLKKASTEGRQKAREALMADGGGLNCAYRISWLQDQITTVLYNFATAHIFPQQKDKFAVTAVGGYGRDTLAPGSDIDLLFLFLPRPAEETHKAVEFMLYVLWDMGFKVGHATRTVEECIALSKSDMTIRTAILEMRYICGLQRLETELETRFDKEIVTGTGPEFIAAKLAERDERHRKAGDTRYLVEPNVKEGKGGLRDLHTLFWISKYYYHVRDQAELVKLGVLSKHEYRLLEKADDFLWAVRCHMHFLTGKAEERLSFDIQREIAEAFGYHTRPGLSAVERFMKHYFLVAKDVGDLTRILCAALEDQQAKSIPGLTGVISRFTHRNRKIAGSVEFVEDRGRIALADPEVFKRDPVNIIRLFHVADINGLEFHPDALKRVTRSLALIDNALRENDEANRLFMSILTSKRDPALILRRMNEAGVLGRFIPEFGKIVAMMQFNMYHHYTVDEHLIRTVDILSEIDKGRAEDLHPLANKLMPGIEDREALYVAVLLHDIAKGRQEDHSIAGARVARKLCVRFGLSQKQTEIVVWLIEEHLTMSMVAQTRDLTDRKTITDFADRVQSLDRLKMLLILTICDIRAVGPGVWNGWKGQLLRTLYYETELLLAGGFSEVSRKERANAAAEALHSALADWSQKDRNTYTKLHYQPYLLSVPLEDQIRHAHFIRQADKAGQALATMVRTDSFHAITEITVLSPDHPRLLAVIAGACAAAGANIVDAQIFTTSDGRALDTIHVSREFTDDADELRRAATIGRMIEDVLSGRKRLPEVIATRARNRKKSKAFVIPPSVNITNSLSNKFTVIEVECLDRPGLLSEITAVLSDLSLDIQSARITTFGEKVIDTFYVTDLVGQKISGDSKRANITARMKAVMAEEEDELRERMPSGIIAPAATARTPPASEKKAGSPI
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins GlnB and GlnK, in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD likely hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: TYDC2_NARPS
Sequence: MEESLKPMDAEQLRENAHKMVDFIADYYKSIESFPVLSQVKPGYLRDLLPDSAPDHPESLEDVLEDIRQKIVPGVTHWQSPNYFAYYPSNSSVAGFLGEMISAGFNIVGFNWIASPAATELEVIVLDWLAKMLNLPNQFLSSGQGGGVIQGTASEANLVVLLAARDKFLNRFGKRSLEKLVVYASDQTHAAMKKACQIAGIYPENFRVLNADHTSNYALVPEALSDAISNDLSAGLIPFFLCATVGTTSSAAVDPLSELGKISKVNDMWFHVDAAYAGSACICPEYRHYIDGIEEAASFNMNAHKWFLTNFDCSLLWIKDRSALIQSLSTYPEYLKNKASQENSVVDFKDWQIPLGRRFRSLKLWMVLRLYGLENLQSYIRNHIKLAGQFEQLVCSDSRFEVVVPRTFSLVCFRLLPPPNHQDNGYKLNHSLLDAVNSSGKIFVSHTVLSGKYVIRFAVGAPLTEEEHIKQAWKVFQDQATILLAGSDGSDFGASNGDII
What is the function of this protein?
Catalyzes the decarboxylation of L-tyrosine to tyramine, which is converted to norbelladine, a precursor to all Amaryllidaceae alkaloids such as galanthamine, lycorine and haemanthamine, and including haemanthamine- and crinamine-type alkaloids, promising anticancer agents.
What are the official names of this protein?
Tyrosine decarboxylase 2.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: LGI2_HUMAN
Sequence: MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKGFYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHIIVDLSL
What is the function of this protein?
Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells.
What are the official names of this protein?
Leucine-rich repeat LGI family member 2, LGI1-like protein 2, Leucine-rich glioma-inactivated protein 2.
What are the subcellular locations of this protein?
Secreted.
Protein: ISCU2_ARCFU
Sequence: MYSDKVFDHFQNPRNVGKIEDADGVGTVGNPVCGDLMTIYIKVKDNRIEDIKFQTFGCAAAIATSSMATEMAKGKTIEEALKITRDAVAEALGGLPKQKMHCSNLAADALRRAIVDYFRKNGKIDKIKELGLEKELEKMEKGEMDDHGEYCEA
What is the function of this protein?
A scaffold on which IscS assembles Fe-S clusters.  Subsequently gives the nascent cluster to other proteins.  Binds 1 2Fe-2S cluster per subunit in a crystal formed under reducing conditions; this subunit provides 3 ligands while IscS2 provides the other ligand.  It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
What are the official names of this protein?
Iron-sulfur cluster assembly scaffold protein IscU 2, Sulfur acceptor protein IscU 2.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
Protein: RIBBA_STAAC
Sequence: MQFDNIDSALMALKNGEPIIVVDDENRENEGDLVAVTEWMNDNTINFMAKEARGLICAPVSKDIAQRLDLVQMVDDNSDIFGTQFTVSIDHVDTTTGISAYERTLTAKKLIDPSSEAKDFNRPGHLFPLVAQDKGVLARNGHTEAAVDLAKLTGAKPAGVICEIMNDDGTMAKGQDLQKFKEKHQLKMITIDDLIEYRKKLEPEIEFKAKVKMPTDFGTFDMYGFKATYTDEEIVVLTKGAIRQHENVRLHSACLTGDIFHSQRCDCGAQLESSMKYINEHGGMIIYLPQEGRGIGLLNKLRAYELIEQGYDTVTANLALGFDEDLRDYHIAAQILKYFNIEHINLLSNNPSKFEGLKQYGIDIAERIEVIVPETVHNHDYMETKKIKMGHLI
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: UTP25_RAT
Sequence: MGKRRSRGRSQLLSTMTKKQKKHLRDFGEEHPFYDRVSKKEVKPQICQLSESSDSSHSESESESEQEHVSGYHRLLATLKNISEEEEEEEEEEEEEEEDKEEVDDSAVGDSEMNGEDGGEDVRVEETAESSETQDHMSLADNSKGKDGEEPPGVSQKSSEEFTDVKHESLFSLETNFLEEESGGSYSQRTSQDPFQHHINKELQEKEIQAAASSPAATQQLKWPVLGHLVFSSKFQKMETFKPPKDIDLKSLHLQKPLESTWAKTNSQFLSGPGPQKSSSCFTPLQKELFLIMNSYRDLFYPERTALKNGEEVRHVYCLHAINHVLKANAQVLANNSRRRTQKLGVGDDDDFRDQGLTRPKVLIVVPFREAALRVVQLFISLLEGDSKKKIIVSNKKRFQGEYGSDPEERPPNLKRPEDYEAVFVGNIDDHFRIGVAILQRSIRLYAPFYSSDILIASPLGLRTIIGGEGEKKRDFDFLSSIELLIIDQADIYLMQNWEHVLHLMNHMNLLPLDSHGVNFSRVRMWSLNNWSKYYRQTLLFGALQDAQINSVFNKHCVNAQGQVAVRNVPMTGSISHVLVQLPHVFQRMEAQDLASVIDARFHFFINKILPQYRDAVMSHTLIYVPSYFDFVRLRNYFKKEELNFTHICEYTQRSGVSRARHFFLQGEKQFLLLTERFHFYKRYTIKGIRNLIFYELPTYAHFYSEVCNMLRATSRGEEATWTCTVLYSKYDAQRLAAVVGVERAAQMLQSPKSVHLFITGEK
What is the function of this protein?
Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity).  Essential for embryonic development in part through the regulation of p53 pathway.  Controls the expansion growth of digestive organs and liver (By similarity).  Also involved in the sympathetic neuronal development (By similarity).  Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (By similarity).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25 homolog, Digestive organ expansion factor homolog, UTP25 small subunit processor component.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CBIO_SALPA
Sequence: MLATSDLWFRYQDEPVLKGLNLDFSLSPVTGLVGANGCGKSTLFMNLSGLLRPQKGAVLWQGKPLDYSKRGLLALRQQVATVFQDPEQQIFYTDIDSDIAFSLRNLGVPEAEITRRVDEALTLVDAQHFRHQPIQCLSHGQKKRVAIAGALVLQARYLLLDEPTAGLDPAGRTQMIAIIRRIVAQGNHVIISSHDIDLIYEISDAVYVLRQGQILMHGAPGEVFACTEAMEHAGLTQPWLVKLHTQLGLPLCKTETEFFHRMQKCAFKEAS
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.  Presumably responsible for energy coupling to the transport system.
What are the official names of this protein?
Cobalt import ATP-binding protein CbiO, Energy-coupling factor transporter ATP-binding protein CbiO, ECF transporter A component CbiO.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS5_MYCS5
Sequence: MEDKKLSSAKPATSSKPAPKAPSTGTKVVTKPASGPRPAFKPGQRKPHASNASNDKVAFEKRNFTSGDKTKKPTDSKNPRFQRNNKDRKFVSEYEEKIVDIARVTKVVKGGRRFSFSAFVVIGNKKGTVGYGHGKANEVPDAIKKAIKDAHNNLVEVPITKGTVPHEVTAKFLASKVLLKSAPKGKGLIASSRVRAVVELAGYTDIVSKTYGSRSAQNVVKSVVKALLNLRTAKQIAEVRDKDVKDLL
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: ATPD_RHOCA
Sequence: MSEPASISAAIAGRYATAIFDLAQEAKGIDALSADVDALTAALAGSAELRDLISSPVYTREEQGDAIAAVAAKMGLSAPLANGLKLMATKRRLFALPQLLKGLAAAIAEAKGEMTADVTSATALSAAQAEKLAATLAKQTGKTVKLNVAVDESLIGGMIVKLGSRMIDTTVKAKLASLQNAMKEVG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cellular chromatophore membrane; Peripheral membrane protein.
Protein: TEX14_MOUSE
Sequence: MSRGAPFPVPCPVLLGTFTDDSLEAQLHEYAKQGNCVKLKKILKKGVCVDAVNTQGQSALFVAALLGHVKLVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLTAGGDLRLHDEKGRNPQAWALTAGKDRSTQMVEFMQRCTSHMKAIIQGFSYDLLKKIDSPQRLIGSPPWFGSLIQGSPNSSPNRQLKPGIISAQNIYSFGFGKFYLTSGMQLTYPGSLPVIGEKEVVQADDEPTFSFFSGPYMVMTNLVWNRSRVTVKELNLPTRPHCSRLRLADLLIAEQEHSSNLRHPNLLQLMAVCLSRDLEKIRLVYERITVGTLFSVLHERRSQFPVLHMEVIVHLLLQVADALIYLHSRGFIHRSLSSYAVHIVSAGEARLTNLEYLTESQDSGAHRNVTRMPLPTQLYNWAAPEVVLQKAATVKSDIYSFSVIIQEILTDSIPWNGLDGSLVKETIALGNYLEADVRLPEPYYDIVKSGIHAKQKNRTMNLQDIRYILKNDLKEFIGAQKTQPTESPRGQSYEPHPDVNICLGLTSEYQKDPPDLDIKELKEMGSQPHSPTDHSFLTVKPTLAPQTLDSSLSAQKPDNANVPSPPAACLAEEVRSPTASQDSLCSFEINEIYSGCLTLGTDKEEECLGTAASPEGDRPNQGDELPSLEEELDKMERELHCFCEEDKSISEVDTDLLFEDDDWQSDSLGSLNLPEPTREAKGKTSSWSKTDEYVSKCVLNLKISQVMMQQSAEWLRKLEQEVEELEWAQKELDSQCSSLRDASLKFANAKFQPAVGPPSLAYLPPVMQLPGLKQPENGGTWLTLARSPGNEREFQEGHFSKKPEKLSACGWKPFTQVSEESRGDCSELNNQLPTLRGPGKQSTGEQLPSTQEARESLEKNTNQNSRSMASVSSEIYATKSRNNEDNGEAHLKWRLAVKEMAEKAVSGQLLLPPWNPQSSAPFESKVENESTPLPRPPIRGPESTEWQHILEYQRENDEPKGNTKFGKMDNSDCDKNKHSRWTGLQRFTGIRYPFFRNHEQPEQNEASQASCDTSVGTEKFYSTSSPIGDDFERFQDSFAQRQGYVEENFQIREIFEKNAEILTKPQFQAIQCAEDKQDETLGETPKELKEKNTSLTDIQDLSSITYDQDGYFKETSYKTPKLKHAPTSASTPLSPESISSAASHYEDCLENTTFHVKRGSTFCWNGQEAMRTLSAKFTTVRERAKSLESLLASSKSLPAKLTDSKRLCMLSETGSSNVSAAFVTSTHATKRKSLPRELAEATSQQHLDELPPPAQELLDEIEQLKQQQVSSLASHENTARDLSVTNKDKKHLEEQETNSSKDSSFLSSREIQDLEDTERAHSSLDEDLERFLQSPEENTALLDPTKGSTREKKNKDQDVVEQKRKKKESIKPERRESDSSLGTLEEDELKPCFWKRLGWSEPSRIIVLDQSDLSD
What is the function of this protein?
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis.  Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility.  Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges.  Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment.  Has no protein kinase activity in vitro.
What are the official names of this protein?
Inactive serine/threonine-protein kinase TEX14, Testis-expressed sequence 14, Testis-expressed sequence 14 protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.
Protein: PGLRX_NEOFI
Sequence: MKFSYSFVQVVSLLLSLSPSVEGFTRSRNDACKPNHPFRPLPPSQPRTKTCHVVSNGHGKDDSKNIMQALHKCNNGGKVVFDANKVYTVGTALDMTFLKHIDLEVLGKIQFTNDTDYWQAHSFKHGFQNATTFFQLGGQDVNVYGGGTFDGNGQVWYDLYAEDALILRPILFGIIGLKGGTIGPLKLRYSPQWYQLVANSSDVIFDGIDISGYSSSKNEAKNTDGWDTYRSDNIVIQNSVINNGDDCVSFKPNSTNIIVQNLHCNGSHGISVGSLGQYKGEVDIVQNVLVYNISMYNASDGARIKVWPGVSSAMSEDLQGGGGLGSVKNITYNQMYIENVDWAIEVTQCYGQKNLTLCNEHPSNLTISDIHFKNFRGTTSGKRDPDVGTIVCSSPNVCSDIHAENINVKSPKGTDEFVCTNVDKSLLDVNCA
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Probable exopolygalacturonase X, ExoPG, Galacturan 1,4-alpha-galacturonidase, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NAC19_ARATH
Sequence: MGIQETDPLTQLSLPPGFRFYPTDEELMVQYLCRKAAGYDFSLQLIAEIDLYKFDPWVLPNKALFGEKEWYFFSPRDRKYPNGSRPNRVAGSGYWKATGTDKIISTEGQRVGIKKALVFYIGKAPKGTKTNWIMHEYRLIEPSRRNGSTKLDDWVLCRIYKKQSSAQKQVYDNGIANAREFSNNGTSSTTSSSSHFEDVLDSFHQEIDNRNFQFSNPNRISSLRPDLTEQKTGFHGLADTSNFDWASFAGNVEHNNSVPELGMSHVVPNLEYNCGYLKTEEEVESSHGFNNSGELAQKGYGVDSFGYSGQVGGFGFM
What is the function of this protein?
Transcription factors that bind specifically to the 5'-CATGTG-3' motif.
What are the official names of this protein?
NAC domain-containing protein 19, ANAC019, Abscisic-acid-responsive NAC, ANAC.
Protein: TX320_LYCSI
Sequence: MKFVLLFGVFLVTLFSYSSAEMLDDFGQADEDELLSLIEKEEARAKECTPRFYDCSHDRHSCCRSELFKDVCTCFYPEGGDNEVCTCQQPKHLKYMEKAADKAKKFGGKIKKWFG
What are the official names of this protein?
U3-lycotoxin-Ls1a, Toxin-like structure LSTX-B20.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VL2_HPV24
Sequence: MVRAKRTKRDSATNIYRTCKQAGTCPPDVINKVEQSTIADNILKYGSAGVFFGGLGISTGRGTGGTTGYVPLGEGTGVRVGSTPTVVRPALVPEVIGPADLLPVDTIAPVDPASSSIVPLTESSGVDLLPGEIETIAEVHPIPDVPTFDTPVVTTSKGSSAILEVAPEPTPPTRVRVSRTQYHNPAFHIITESTPSQGESSLSDEIIVASGAGGQSVGVSENIELQDLSNRYSFEIETPTPPRRSSTPLQRATQAFRQRSLTNRRLLQQVPVEDPLFLTQPSKLVRFAFENPAFEEEVTQVFEQDLAGFVEPPNRDFLDIAELGRPRFSETREGYVRLSRLGRRATIRTRAGTQIGAQVHFYKDLSSINTEAPIELDLLGQHSGDATIVHGTVESTFIDTNIEENPLAEQMELEIDTYPEAHSFDALLDEATDDFSGSQLVIGNRRSTTSYTVPRFESPRNSSYYVQDLQGYYVAYPESRDKIELIYPSPTLPAVVIHTEDSSGDFYLHPSLLQRRRRKRKYL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: CO1A1_CHICK
Sequence: MFSFVDSRLLLLIAATVLLTRGEGEEDIQTGSCVQDGLTYNDKDVWKPEPCQICVCDSGNILCDEVICEDTSDCPNAEIPFGECCPICPDVDASPVYPESAGVEGPKGDTGPRGDRGLPGPPGRDGIPGQPGLPGPPGPPGPPGLGGNFAPQMSYGYDEKSAGVAVPGPMGPAGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPAGPPGKNGDDGEAGKPGRPGQRGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGQPGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGPSGPAGARGNDGAPGAAGPPGPTGPAGPPGFPGAAGAKGETGPQGARGSEGPQGSRGEPGPPGPAGAAGPAGNPGADGQPGAKGATGAPGIAGAPGFPGARGPSGPQGPSGAPGPKGNSGEPGAPGNKGDTGAKGEPGPAGVQGPPGPAGEEGKRGARGEPGPAGLPGPAGERGAPGSRGFPGADGIAGPKGPPGERGSPGAVGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPAGPPGARGQAGVMGFPGPKGAAGEPGKPGERGAPGPPGAVGAAGKDGEAGAQGPPGPTGPAGERGEQGPAGAPGFQGLPGPAGPPGEAGKPGEQGVPGNAGAPGPAGARGERGFPGERGVQGPPGPQGPRGANGAPGNDGAKGDAGAPGAPGNEGPPGLEGMPGERGAAGLPGAKGDRGDPGPKGADGAPGKDGLRGLTGPIGPPGPAGAPGDKGEAGPPGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGETGDAGAKGDAGPPGPAGPTGAPGPAGZVGAPGPKGARGSAGPPGATGFPGAAGRVGPPGPSGNIGLPGPPGPAGKZGSKGPRGETGPAGRPGEPGPAGPPGPPGEKGSPGADGPIGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGEAGREGAPGAEGAPGRDGAAGPKGDRGETGPAGPPGAPGAPGAPGPVGPAGKNGDRGETGPAGPAGPPGPAGARGPAGPQGPRGDKGETGEQGDRGMKGHRGFSGLQGPPGPPGAPGEQGPSGASGPAGPRGPPGSAGAAGKDGLNGLPGPIGPPGPRGRTGEVGPVGPPGPPGPPGPPGPPSGGFDLSFLPQPPQEKAHDGGRYYRADDANVMRDRDLEVDTTLKSLSQQIENIRSPEGTRKNPARTCRDLKMCHGDWKSGEYWIDPNQGCNLDAIKVYCNMETGETCVYPTQATIAQKNWYLSKNPKEKKHVWFGETMSDGFQFEYGGEGSNPADVAIQLTFLRLMSTEATQNVTYHCKNSVAYMDHDTGNLKKALLLQGANEIEIRAEGNSRFTYGVTEDGCTSHTGAWGKTVIEYKTTKTSRLPIIDLAPMDVGAPDQEFGIDIGPVCFL
What is the function of this protein?
Type I collagen is a member of group I collagen (fibrillar forming collagen).
What are the official names of this protein?
Collagen alpha-1(I) chain, Alpha-1 type I collagen.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: FK110_ARATH
Sequence: MTEEMSKESPPPPPTSFSSLPDDVALDCRARISRFHYPTLSLVSKGFRTLIASPELEATRSFIGKPENHLCVCLRLYKNPNPLWFIFSPIPKQKLKPIVPWFPNQQYPQYPTVVSNGSQIYIIGGFVRRRRSNRVSIFDYRTYQWRRLPKMRQPRVYPAASVIDGKIYVIGGFRGSMPTDIENSGEVYDPKTNTWEPILLTSLDLTVQNVFKKKHYFTTKACLVINKVSCLLYVSDGKLYWREDKEGFECRKVYGLAEQSSNLFRVVANSGGGGRVTVWWKSMTKGCEFDCLLTEECETKIWCAEISLERRGLRELRGFVEWSKEVFTIDRCDYIYDFISQYVTVTY
What are the official names of this protein?
F-box/kelch-repeat protein At5g03020.