PharMolix/UniProtQA huggingface dataset:
Protein: PERI_HUMAN
Sequence: MSHHPSGLRAGFSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSFRSPRAGAGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQKEQRSELDKSSAHSY
What is the function of this protein?
Class-III neuronal intermediate filament protein (By similarity).  May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15446584, PubMed:15322088).  Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity).  Plays a role in the development of unmyelinated sensory neurons (By similarity).  May be involved in axon elongation and axon regeneration after injury (By similarity).  Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).
What are the official names of this protein?
Peripherin, Neurofilament 4.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon. Perikaryon.
Protein: MSCL_METEP
Sequence: MLEEFKKFALRGNVVDLAVGVIIGAAFGAIVNSLVQDVIMPIIGAVTGGLDFSNYYIPLSSKVQDGMPYAEAKKVGAVIGYGQFLTLAVNFTIIAFVLFMVIRAMNVLKSREEAKPKPVAEVPADVKLLGEIRDLLAARRV
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPL_MYCSJ
Sequence: MDPTIAAGALIGGGLIMAGGAIGAGIGDGIAGNALIAGIARQPEAQGRLFTPFFITVGLVEAAYFINLAFMALFVFATPVA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL30_RICPR
Sequence: MNNKINNIKITQIKSAIGCKYDQRFTLIGLGLNKINKSVILKNTNSIRGMVEKVKHLLKIENM
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RS6_SYNP6
Sequence: MKDFYYETTYILRADLTEEQVEQAIAKYQTPLTEAGAEVQDTQHRGKRRLAYLINKQREGIYVQINYTGDGSQIAPLERALRLSEEVLRFLTVKQEVRPPAPVAVEA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: GMHA_SALA4
Sequence: MYQDLIRNELNEAAETLANFLKDDANIHAIQRAAVLLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHISCVSNDFGYDYIFSRYVEAVGREGDVLLGISTSGNSGNVIKAIAAAREKGMKVITLTGKDGGKMAGTADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVK
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROBN_OLEEU
Sequence: MSWQAYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGETKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVFGIYEEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-3, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: AROC_STAAU
Sequence: MRYLTSGESHGPQLTVIVEGVPANLEVKVEDINKEMFKRQGGYGRGRRMQIEKDTVEIVSGVRNGYTLGSPITMVVTNDDFTHWRKIMGRAPISDEERENMKRTITKPRPGHADLLGGMKYNHRDLRNVLERSSARETAARVAVGALCKVLLEQLDIEIYSRVVEIGGIKDKDFYDSETFKANLDRNDVRVIDDGIAQAMRDKIDEAKTDGDSIGGVVQVVVENMPVGVGSYVHYDRKLDGRIAQGVVSINAFKGVSFGEGFKAAEKPGSEIQDEILYNTELGYYRGSNHLGGLEGGMSNGMPIIVNGVMKPIPTLYKPLNSVDINTKEDFKATIERSDSCAVPAASIVCEHVVAFAIAKALLEEFQSNHIEQLKQQIIERRQLNIEF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: MTGA_AERHH
Sequence: MRPALARRLLSGLGKLLLAALLSTIVSVALLRFIDPPMWTWRLERALFPPAKVAEVKHDWVPLEQISRELQLAVIAAEDQRFAEHNGFDMDAISSALKHNQHSERVRGASTLSQQTAKNLFMWSDRSFLRKGIEAWFTLLMELGWDKSRILEMYLNIVEFGPGIYGAEAAARHYFGKPAARLTRYEASLLAAALPNPWRYRVKPPSPYVQQRSAWIRRQMGQLGQITLNKVHQAD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IL6_MOUSE
Sequence: MKFLSARDFHPVAFLGLMLVTTTAFPTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLHKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT
What is the function of this protein?
Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability.  Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:17075861).  Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:11786910).  'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851).  Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (PubMed:11113088).  Also acts as a myokine (By similarity).  Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088, PubMed:8910279).  Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018).  Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
What are the official names of this protein?
Interleukin-6, IL-6, B-cell hybridoma growth factor, Interleukin HP-1.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXD2_LEGPH
Sequence: MSNYQFTKPAGPFRLFELAKISGATLYEGKGETFTVSGLAKLSEATSNDLVMLHQKKYVKELKHTAARVCIIGPDYVKYAPDSMYLLVHPNPYKAFALIAQAFYPSEKPPGFIATSAMIESSAIIGVDCFIAHGAYIGNQVKIGNRCKIGVNTYIGDTVTIGDDCLIEDNVSIRHAVIGNNVVIYSGARIGQDGFGFASDANGHYKIPHAGGVIIGNDVEIGANTCIDRGSLDNTVIEDWCRLDNLVQIGHNVKIGKGSVLVAQVGIAGSTELGEHVTLAGQVGVIGHLKIGKGATVLASAKVYKNVKSGDRVGGHPAVSISDWQKQIRFLKTAIKSKKSPKS
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: RL14_STRPG
Sequence: MIQQETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVKQATPGGAVKKGDVVKAVIVRTKTGARRPDGSYIKFDDNAAVIIRDDKTPRGTRIFGPVARELREGGYMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: NRDR_AKKM8
Sequence: MRCVQCGHLEDKVIDSRMSKDGTTIRRRRVCLRCDYRYTTYEQIERTELRVVKRDNLREALNREKILRGLVKACEKRPVSMDRLDRAVEEIISELHRDHLREVPSSEIGKKVIEKLYAIDPVAYIRYVSVYRQFSNVEEFIQEITQMRHQTLIDPLQRKLPIL
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: MSRB_ECOSE
Sequence: MANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKYDSGCGWPSFYEPVSEESIRYIKDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLRFTDGENGEEING
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: COWN_RHOVT
Sequence: MSEQIDRYVSFKNIDCNARAGQMMDALQPYIQAAENPFWAYFQQKRAEFNAKGYDDLRVLHNYLPTLKELIEDDELLAQLEDLEYTCM
What is the function of this protein?
Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO).  Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.
What are the official names of this protein?
N(2)-fixation sustaining protein CowN, CO weal-nitrogenase.
What is the protein family that this protein belongs to?
Belongs to the CowN family.
Protein: Y0G0_VIBCH
Sequence: MMNQTYTAVLADDEPLLRHHLNKLLAELWPALEIVASAENGQIALQAIEQHQPDVVFLDIRMPKMDGIEVARRLLQQPKVPLVVFITAYDEYAVSAFETHAIDYLLKPLSSSRLASCCEKLQQQLRRNVAPSNDLAQLMSQFEQLTRTVKPQYQVWLKASKGEEIHLIAVNELLYVKAEDKYLSLYKVHGATTHEYLLRSSLKELLAQLDPNQFWQIHRSIVVNVGKIDKVTRDFGGKMWVHIDRLQLPVSRALQHLFKVS
What are the official names of this protein?
Uncharacterized response regulatory protein VC_A0850.
Protein: Y281_TREPA
Sequence: MYLAVVPVCCSFPWAGVGLRCSRLSVRVLELSDSVRGGGIHA
What are the official names of this protein?
Uncharacterized protein TP_0281.
Protein: MLNS_PHANO
Sequence: MATPDDPATPALSLSASNSSSPTAASSVPPPTGTSEIQYDDVAIIGMSCRTAGGNDSPEKLWRFIMDKKDASGESPSWRWEPWVRRDTRNAKVIEKTISKGYFIEDLENFDASFFGISPKEAEQMDPHQRLGLEVTWEALEDAGINPQSLSGSDTAVYVGVDSDDYSRLLLEDIPNIEAWMGIGTTAHGIPNRISYHLDLMGPSAAVDAACASSMVAVHTGRQAILAGESRIAIVGGVNVCLSPALFHMLGAAGALSPDGVCLSFDEEARGYARGEGAAILILKKMSHAIMDGDHILATIKGSAIAQDGKTNGIMAPNAKAQELVARKALKQAGINALTVGYIEAHATSTPLGDPTEVSAISAVYGVGRPTDTPALIGSIKPNVGHLEAAAGAISLVKAVMAVQKGIVPPQTRLNKLNTRVDWAKSGLHVVRESTQWGTEDSPRRAAICSYGYGGTVSHAIIEQFAHAADPFTASTSDDNHPTLLLLSAPQGKQRLPAQSAALAEWISPAGAHESLRSIAATLATRRAHHENRAAFIVSSHTEAAETLNLFSKGAEHDSIVQSRTLDNNINKQIVWVFSGHGSHWSGMGKQLLQNAVFYRTVAPLDIVVVQELGYSAIEALKTGRFESSGQVQVLTYMTQIGLIQLLKAKGVHPHAVIGHSVGEIAASVAAGCLTPEEGMIIVTRRARLFAKVIGCGGMFLVSLPFAEVLAELGGRTDIVAAIDSSPSSCVISGLNAPLEEYVEKLKNRGIRVFQVKTDIAFHSPMLEVLSKPLKESLEGSLNPQPPNIKLYSTSQADTRHPARRDAEYWVDNMVKPVWLRPAVTAAIEDHYRIFMEVSTHPIVSHSLDETLAENGASDFTTIHTMKKEQSAEKCILHAVAQLWTKGVKIDFKFLGRQWSREVPKIRWSHKRFWKEVSTGSASAQTVHDPDKNNMLGQRMVVAGTNMTIFTTALDESSKPFPMPHQLHGTDIIPVSVYVNTFIKATGGKVLSKMELRVPLAVTNDVRNVQVIVDGQSVKVASRLSSSDDMSWVTHSTASWENEPSANVLPSLDVSSVIKRIGTRVSETFSVDYLKKTGVSGMAFPWAVNDHYNNTKEMLVTLDNDPEHETMSWDPCSWGATLDAATSVGATLFSREVKLRIVSHIDRLTIYSSDPPPKRYHLYVTEASSSQVHACSADISVLDLSGTLLARIESIRFTEVEATPTKSTSIESGVHQIAWVPARLSEKPLSLEQIVLVSEDDAKLEQYANELQRQAPKIVKLTSAAKLRDNGALFMREKNATVIYCPGTVTSLEDVASASHRFIWEVATAIKFLVENSISAKFFVILDRTFLAGSPTALAQGALYGLARVVASEHSDIWGGLIDNEGPLFPVMPLKYVQDQDITRYIDGVPRVARMRPFTKQQRYAPSTARTLLPKPEGTYVLTGGLGALGLETCDFLIEKGARRIVVISRRDIPARSQWSKASENLAPILERVKAMEKTGASIYFVSLDIGAADAHQQLLFALERLSLPPVLGVIHASGVLEDSLLVDTTSDSFARVLSPKISGALALHKAFPPGTLDFFVLYSSIGQLVGTSGQSSYAAGNSFLDVLAAHRRSQGDNAIAFQWTAWRGLGMATSTDFLTLELQSKGITDVGRDEAFQAWEHMSKYDVDQAVVTRTLALEADDILPCALLEEVVVRKARAQDQSAPASGNASDSSGRPTASADLKPWLDVKIRECVALVMGVEDIEEIDTRVPLSDYGVDSIMTIALRQKLQSKLKIKVPQTLMWNYPTVSAMVGWFQKQFEEGQ
What is the function of this protein?
Polyketide synthase that produces (R)-mellein, a secondary metabolite that inhibits the germination of wheat (Triticum aestivum) and barrel medic (Medicago truncatula) seeds (PubMed:25326302).  Condensates 1 acetate starter unit and 4 extender malonate units (PubMed:25326302).  The nascent pentaketide intermediate then undergoes an aldol cyclization and is aromatized via dehydration (PubMed:25326302).  The (R)-O-methylmellein isolated from P. nodorum is most likely to be derived from (R)-mellein via an additional methylation at the hydroxyl group.  Interestingly, no O-methyltransferase gene is encoded in the vicinity of MLNS on the chromosome.  Thus, the O-methylation is likely to be catalyzed by an endogenous O-methyltransferase encoded elsewhere in the genome of P. nodorum (PubMed:25326302).
What are the official names of this protein?
Mellein synthase, Polyketide synthase MLNS, PKS MLNS.
Protein: HLDE_CAMFF
Sequence: MVNVLVVGDLMIDHYVWGSCDRISPEAPVQVVNIKNETKRLGGLGNVVSNLKTLGSEVGVISVVGDDDVGDEILELLKDRGAKTELIIKEKGRKSSQKSRIMVAHQQVLRLDTESVCEIGVSDDIISKFENILSGYDIVLLSDYGKGVLSPYLTKEIIRITKKSGKMVLIDPKGKDYSKYSGATLLTPNKKEASEALGFGINDEDDLKHALKMLKDKFKLNYSLITLSEDGIALLDEDVKKFPALAKEVFDVTGAGDSVLATLGYCLASKMSLEESIEIANLAAAVVVGKVGSADASWGEIENLKSKKSGFERKIISLDELLRVDRSGKTMVFTNGCFDILHFGHISYLQSAKKIGDMLVVGLNSDRSVKELKGDNRPVNAQSDRASMLAALEFVDFVVIFDEDTPLNLIKTLKPDILVKGADYTGKKVVGSEFVREVKLIDFVDGKSTTNIINKIKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: NUOB_RHOJR
Sequence: MGIEEKLPSGFLLTTVEGLAGYVRKGSLWPASFGLACCAIEMMATAGGRFDIARFGMEAFRASPRQADLMIVAGRVSQKMAPVLRQIYDQMVEPKWVLAMGVCASSGGMFNNYAIVQGVDHIVPVDIYLPGCPPRPEMLLNAILTLHEKIQQMPLGVHREEVARAAEQAALAATPTIQMKGLLR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VATE_METJA
Sequence: MKLMGVDKIKSKILDDAKAEANKIISEAEAEKAKILEKAKEEAEKRKAEILKKGEKEAEMTKSRIISEAKLEAKKKLLEAKEEIIEMAINKLKEELVKLPEQPEYKDKLIKLIKDGAISLGGGELIVRLNKRDMELIDDSTLWNLEKEVENATKKVTVLKKGEPVDIAGGCIIETADGLKSLDNSLEAIFNRNLNVIRARITEKLF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: Y5030_PSEPG
Sequence: MLKKTFAALALGTALLSAGQAMAAEYKIDKEGQHAFVDWKISHLGYSFIHGTFKDFDGNFTWDSAKPEASKISVDLKTASLWSNHAERDKHIASADFLDVKKYPEAKFVSTAVKSTGEKTADVTGDLTMHGVTKPVTFKATFNGEGKDPWGGERAGFNATTTLNLNDFGIKGPGATSQTLDLDISVEGVKQK
What are the official names of this protein?
UPF0312 protein PputGB1_5030.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: CR3L4_RAT
Sequence: MELGCPELLEPPEDIFSTGSFLELGFNGPPSKVPGLQKSESDDFLNLFIDPNMIRCSETSPGSDSGVSEDPGSPAPQAPSSPALYEVVYEAGALQGTQREAGPTFGLISIQIDQWSPAFMVPGACTVSDLPSEAHRHILPRVSTIAPPPPAALLSCQRLFLTDEEKHLLGQEGVTLPSHLPLTKAEERILKKIRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSEQNQKLQRKVQELERQNISLVAQVHQLQKFTAQTSSRAAQTSTCVLILLFSLALIILPSFSPFQSQPEARSEGYQLHGVISRNILTHEDMTESPESPVLKANLEELPQVPATNGSTKMAHLKMRVKARPTGPIRGMVHADEM
What is the function of this protein?
Transcriptional activator that may play a role in the unfolded protein response.  Binds to the UPR element (UPRE) but not to CRE element.  Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE.  Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.  Increases the binding of CREM isoform Delta with CRE.  The CREM isoform Delta-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange (By similarity).
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 4, cAMP-responsive element-binding protein 3-like protein 4, Androgen-induced basic leucine zipper protein, AIbZIP.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Protein: STAD_CARTI
Sequence: MALRITPVTLQSERYRSFSFPKKANLRSPKFAMASTLGSSTPKVDNAKKPFQPPREVHVQVTHSMPPQKIEIFKSIEGWAEQNILVHLKPVEKCWQAQDFLPDPASEGFDEQVKELRARAKEIPDDYFVVLVGDMITEEALPTYQTMLNTLDGVRDETGASLTPWAVWTRAWTAEENRHGDLLHTYLYLSGRVDMRQIQKTIQYLIGSGMDPRTENSPYLGFIYTSFQERATFVSHGNTARHAKDHGDVKLAQICGTIASDEKRHETAYTKIVEKLFEIDPDGTVLAFADMMRKKISMPAHLMYDGRDDNLFEHFSAVAQRLGVYTAKDYADILEFLVGRWKVADLTGLSGEGRKAQDYVCGLPPRIRRLEERAQGRAKEGPVVPFSWIFDRQVKL
What is the function of this protein?
Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain.
What are the official names of this protein?
Stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic, Stearoyl-ACP desaturase, Acyl-[acyl-carrier-protein] desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid. Note=In green tissue, found in chloroplasts. In non-photosynthetic tissue, found in plastids.
Protein: LGT_ERYLH
Sequence: MADAASQPIYWSELGLSPGIDLGFFTLRFYSLAYIVGIVLAYWHLGKMIKAPGAPMAQSHADDLFFYCTLGVIFGGRIGYVLFYRPDLLGTLDMFKVWEGGMSFHGGVIGVVLAILFVSWRGKLNWLRVCDYIAVNVPFGMFLGRMANFVNGELYGRPTDVSWAMIFPTDPDQVARHPSQLYQAGLEGLLMMAVMLLLFWQTRARWRPGVLVGVFTIGIAGARFVNEFFRAPDAHLADVVRDTGLSQGQWLSIPMILVGLAVVVYALTRKTKGTPEKPASA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAP1_MOUSE
Sequence: MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDGKEERDKDDQEWESTSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHVSPRTQHIQQPRK
What is the function of this protein?
Negative regulator of autophagy.  Involved in mediating interferon-gamma-induced cell death (By similarity).
What are the official names of this protein?
Death-associated protein 1, DAP-1.
Protein: PPAX_BACC4
Sequence: MRINTVLFDLDGTLINTNELIISSFLHTLNTYYPNQYKREDVLPFIGPSLHDTFSKIDENKVEEMITSYRKFNHDHHDELVEEYETVYETVRELKRQGYKVGIVTTKARQTVEMGLQLSKLDEFFDVVVTIDDVENVKPHPEPLQKALELLDAKPEEALMVGDNHHDIVGGQNAGTKTAAVSWTLKGRAYLEAYKPDFMLDKMSDLLPILSNMNRS
What is the function of this protein?
Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P.  Might play a role in controlling the intracellular pyrophosphate pool.
What are the official names of this protein?
Pyrophosphatase PpaX.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PpaX family.
Protein: POPD1_XENTR
Sequence: MATESILITTLPMDLNSQINNVTFGLNENETLCENWREIHHLVFHLANTCFAAGLVIPSTLNLHMILLRGMLCLGCIFFIIWAILFRCALDIMIWNATFLSMNFMHFIYLVYKKRPIKIEKDLKGIYHRMFEPLHVSPELFNRLTGQFCEIKTLAKGQTYAIEDKTSVDDRLSILLKGIMKVSYRGHFLHAISPNAYIDSPEFRSTEMNRGETFQVTITADDNCVFLCWSRERLTYFLESEPFLYEIFKYLIGKDITTKLYSLNDPTLGKKKKLDTQPSLCSQLSVMEMRNSLASTSDNEDGLQTFLRGTSTTSSQRNNQQEFCNAYGVGPLSHAVFC
What is the function of this protein?
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity.  May play a role in vamp3-mediated vesicular transport and recycling of different receptor molecules.  May be involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells.  May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner.  May be involved in epithelial movement during corneal sheet formation and regeneration.  May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity.  May be involved in skeletal muscle and heart development as well as in the maintenance of heart function.  May also be involved in striated muscle regeneration and in the regulation of cell spreading (By similarity).
What are the official names of this protein?
Blood vessel epicardial substance, Popeye domain-containing protein 1, Popeye protein 1.
What is the protein family that this protein belongs to?
Belongs to the popeye family.
What are the subcellular locations of this protein?
Lateral cell membrane. Cell junction, tight junction. Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Membrane, caveola. Note=Detected at points of cell-cell contact in confluent epithelial sheets. Colocalizes with components of the adherens and tight junctions (By similarity).