PharMolix/UniProtQA huggingface dataset:
Protein: FBIB_MYCS2
Sequence: MSAAANAEHGAADRVEILPVPGLPEFRPGDDLVGSLAEAAPWLRDGDVLVVTSKVVSKCEGRIVAAPSDPEERDTLRRKLIDDEAVRVLARKGRTLITENAIGLVQAAAGVDGSNVGSTELALLPVDPDRSAATLREGLRERLGVTVGVVITDTMGRAWRTGQTDFAIGASGLTVLQGYAGSRDRHGNELVVTEVAVADEIAAAADLVKGKLTAIPVAVVRGLRLPDDGSTAHRLVRAGEDDLFWLGTAEAIELGRRQAQLLRRSVRRFSAEPVPHDAIEAAVGEALTAPAPHHTRPVRFVWVQDSETRTRLLDRMKEQWRADLTADGLDADAVDRRVARGQILYDAPELVIPFLVPDGAHSYPDDARTAAEHTMFTVAVGAAVQGLLVALAVRDIGSCWIGSTIFAADLVRAELELPDDWEPLGAIAIGYPEQTPQPLGPRDPVPTDELLVRK
What is the function of this protein?
Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.  Is able to add up to six glutamates to F420-0, producing F420-3 as the major product with lesser amount of F420-4,5,6, consistent with it producing the polyglutamated F420 compounds present in Mycobacterium smegmatis.
What are the official names of this protein?
Bifunctional F420 biosynthesis protein FbiB.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the CofE family.
Protein: RNM_ECOLI
Sequence: MSDTNYAVIYDLHSHTTASDGCLTPEALVHRAVEMRVGTLAITDHDTTAAIAPAREEISRSGLALNLIPGVEISTVWENHEIHIVGLNIDITHPLMCEFLAQQTERRNQRAQLIAERLEKAQIPGALEGAQRLAQGGAVTRGHFARFLVECGKASSMADVFKKYLARGKTGYVPPQWCTIEQAIDVIHHSGGKAVLAHPGRYNLSAKWLKRLVAHFAEHHGDAMEVAQCQQSPNERTQLAALARQHHLWASQGSDFHQPCPWIELGRKLWLPAGVEGVWQLWEQPQNTTEREL
What is the function of this protein?
Exoribonuclease that catalyzes the last steps of 5S, 16S and 23S rRNA 5'-end maturation.  Removes 3 nucleotides (nt) from the 5' end of 5S, 16S and 23S rRNA precursors to generate the mature 5' ends.  Precursors with longer extensions are not processed (7 nt at the 5' end of pre-23S rRNA or 66 nt at the 5'-end of 16S rRNA are not processed).  5S and 23S rRNA maturation occurs more efficiently and accurately on ribosomal particles as compared to free RNA; the enzyme overdigests free RNA but generates the correct 5'-end in ribosomes from rnm deletion strains (PubMed:32343306).  Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base.  Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides.  This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency approximately 10-fold lower than that of the corresponding single-stranded oligonucleotides.
What are the official names of this protein?
5'-3' exoribonuclease Rnm, 3',5'-nucleotide bisphosphate phosphatase, RNase AM.
What is the protein family that this protein belongs to?
Belongs to the PHP family. TrpH/YciV subfamily.
Protein: PANB_BUCAT
Sequence: MESITISQLKNWKRNKKKFAAITAYDFSFSRLFSNCGIPVILIGDSLGMTIQGHTSTLPVKIEDIAYHTKAVRKGAPNTFLISDLPFMSYYDTKQALKNTAKIIRSGANMIKMEGGKWLIEIVRELSNRLILICGHIGLIPQSFHYLGGYKVQGRKENDANKLIDEALLLEEAGINMLILECIPEKLAKKITESLSIPVIGIGSGKNTDGQILVMHDLLGITEGKTPSFTKNFLLESDSIQKAIQKYIYEVEHSIYPSKKHSF
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCS_SHESW
Sequence: MKLPIYLDYAATTPVDPRVAEKMFQYMTMDGIFGNPASRSHRYGWQAEEAVDIARNQVADLINADHREIVFTSGATESNNLAIKGVAHFYNKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLEPASNGIIPMERLEAAMRDDTILVSIMHVNNEIGVIHDIDAIGELCRSKGIIFHMDAAQSAGKLPIDVQATKVDLISISGHKMYGPKGIGALYVRRKPRIRLEAQMHGGGHERGMRSGTLPTHQIVGLGEAAAIAKAEMATDNERIGRLRDKLWNGIKHIEETYINGDLTQRFCGSLNVSFNYVEGESLMMALKDLAVSSGSACTSASLEPSYVLRALGLNDEMAHSSIRFSIGRFTTEEEIDHAIETITQSIDKLREMSPLWEMFKDGIDLNQVQWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_BPK21
Sequence: MAAPDPYKPGKYNDPAGGVESSIGPQTQTQYWMKQALIDARKEAYFGQLASVFGMPKHYGKKIVRMHYIPLLDDRNINDQGIDASGATIANGNLYGSSRDVGTIVGKMPTLTEVGGRVNRVGFKRVLLEGKLEKYGFFREYTQESLDFDSDAELDMHVGREMLKGANEMTEDLLQIDLLNSAGVVRYPGAATQDSEVDATTEVTYDSLMRLNIDLDNNRAPKGTKMITGTRMIDTRTIPGCRPLYCGSELIPTLKAMKDNHGNPAFISIEKYAAGGNTFIGEIGAIDQFRIIINPQMMHWQGAGKAVDPAADGYHDFNDKYSIFPMLVISSEAFTTVGFQTDGKNVKFKIYNKKPGEATADRLDPYGEMGFMSIKWYYGFMVYRPEWIALIKTVARL
What is the function of this protein?
Assembles to form an icosahedral capsid.
What are the official names of this protein?
Major capsid protein, Major virion protein.
What are the subcellular locations of this protein?
Virion.
Protein: PIP11_MUSAC
Sequence: MEGKEEDVRLGANKFSERQPIGTAAQSDKGYKEPPPAPLFEPGELTSWSFYRAGIAEFMATFLFLYITILTVMGVVKSNSKCSTVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRALFYMVMQCLGAICGAGVVKGYQKGLYESNGGGANVVAPGYTKGDGLGAEIVGTFILVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKKHAWDDHWIFWVGPFIGAALAAIYHQIVIRAIPFKSRP
What is the function of this protein?
Water channel required to facilitate the transport of water across cell membrane; mercury-insensitive (By similarity).  Promotes primary root elongation and root hair formation (PubMed:24606771).  Contributes to the tolerance to multiple abiotic stresses including salt (NaCl), cold and water deprivation, by modulating cytosolic K(+)/Na(+) ratio, maintaining osmotic balance, and reducing membrane injury (e. g.  oxidative injury) (PubMed:24606771, PubMed:34512687).  Regulates also the expression of abscisic acid (ABA)-responsive genes during dehydration and salt stresses (PubMed:24606771, PubMed:34512687).
What are the official names of this protein?
Aquaporin PIP1-1, Plasma membrane intrinsic protein 1-1, MaPIP1-1, MaPIP1;1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1533_MYCTU
Sequence: MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPKRLESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQARELIPEGHRTFVDDLLVRYGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHDIRLIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHAAAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAVSPTPVLAAGGIARGRQIAAALALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGKPARMLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR
What are the official names of this protein?
Putative monooxygenase Rv1533.
What is the protein family that this protein belongs to?
Belongs to the nitronate monooxygenase family.
Protein: ARMET_DROWI
Sequence: MNTLHMLLVICCLAGIYQTTLALKEEDCEVCVKTVRKFASSLDDATKKDYKLIEVAFKKYCKTQKNKEHRFCYYLGGLEESATGILNELSKPLSWSMPAEKICEKLKKKDAQICDLRYEKQIDLNNVDLKKLKVRDLKKILNDWDESCDGCLEKSDFIKRIEELKPKYAHNEL
What is the function of this protein?
Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity.  Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity).
What are the official names of this protein?
Mesencephalic astrocyte-derived neurotrophic factor homolog, MANF/CDNF-like protein.
What is the protein family that this protein belongs to?
Belongs to the ARMET family.
What are the subcellular locations of this protein?
Secreted.
Protein: MTNB_NEUCR
Sequence: MCSPTTENNNNNNDHLVQSSDPNHPANLIPALCAKFWTLGWVTGTGGGASIRSDDLVYLAPSGVQKELMKPDDIYVLSLAAQAQSLDKRQRVYLRSPANYKPSQCTPLFLAAFTKRNAGCCIHTHSHWAVLVTLILETQGAGKDREFMINNIEQIKGFGKGFGKSGNLGYHDTLKIPVIENTAHEEDLTEFLEEAMDKYPDTYAVLVRRHGVYVWGENVHKAKTMCESLDYLFQLAVEMKQLGLPWVTDIEPTVPTRK
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTT1_ENCCU
Sequence: MNEVENNNHSFPREDIPTEDEIEEEANSRQGILRYFRVARAEYTKFALLGLMFGIIGFIYSFMRILKDMFVMVRQEPTTILFIKIFYILPVSMALVFLIQYMLGTKTVSRIFSIFCGGFASLFFLCGAVFLIEEQVSPSKFLFRDMFIDGKMSSRSLNVFKSMFLTLNEPLATIVFISAEMWGSLVLSYLFLSFLNESCTIRQFSRFIPPLIIITNVSLFLSATVAGAFFKLREKLAFQQNQVLLSGIFIFQGFLVVLVIFLKIYLERVTMKRPLFIVSSGSRRKKAKANVSFSEGLEIMSQSKLLLAMSLIVLFFNISYNMVESTFKVGVKVAAEYFNEEKGKYSGKFNRIDQYMTSVVVICLNLSPFSSYVETRGFLLVGLITPIVTLMAIVLFLGSALYNTSMEESGLGIVNGLFPGGKPLYVLENYFGVIFMSLLKITKYSAFDICKEKLGMRINPTYRARFKSVYDGIFGKLGKSIGSIYGLLMFEALDTEDLRKATPITAGIIFIFIVMWVKAIIYLSRSYESAVQHNRDVDIDMTEKAKKSLETPEEPKVVD
What is the function of this protein?
ATP transporter involved in the uptake of ATP from the host cell cytoplasm.  Provides the microsporidian cell with host ATP in exchange for ADP.  This is an obligate exchange system.  This energy acquiring activity is an important component of microsporidian parasitism.
What are the official names of this protein?
ADP,ATP carrier protein 1, ADP/ATP translocase 1, Nucleotide transporter 1.
What is the protein family that this protein belongs to?
Belongs to the ADP/ATP translocase tlc family.
Protein: HYI_MOUSE
Sequence: MAPLRFSANVSWLFPELPGLPERLHAAGRAGFKAAEVAWPYTESPQALASAAQTAGLRLVLINTPRGDHEKGEMGLGAVPGRQAAFREGLEQAVLYAKALGCPRIHLMAGRVPQGADRAAVKGEMETVFVENLKHAAGVLAQENLVGLLEPINTRITDPQYFLDTPRQAAAILQKVGRPNLQLQMDIFHWQIMDGNLTGNIREFLPTVGHVQVAQVPDRGEPGSSGELDFTYLFQLLEDEGYQGFVGCEYRPRGDTVEGLSWLRSYWDRRGHPRTGQ
What is the function of this protein?
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
What are the official names of this protein?
Putative hydroxypyruvate isomerase.
What is the protein family that this protein belongs to?
Belongs to the hyi family.
Protein: DIAA_SALCH
Sequence: MLERIKVCFTESIQTQIAAAEALPDAISRAAMTLVHSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHHSARIQEMHMLTVNCLCDLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: COM1_YEAST
Sequence: MVTGEENVYLKSSLSILKELSLDELLNVQYDVTTLIAKRVQALQNRNKCVLEEPNSKLAEILCHEKNAPQQSSQTSAGPGEQDSEDFILTQFDEDIKKESAEVHYRNENKHTVQLPLVTMPPNRHKRKISEFSSPLNGLNNLSDLEDCSDTVIHEKDNDKENKTRKLLGIELENPESTSPNLYKNVKDNFLFDFNTNPLTKRAWILEDFRPNEDIAPVKRGRRKLERFYAQVGKPEDSKHRSLSVVIESQNSDYEFAFDNLRNRSKSPPGFGRLDFPSTQEGNEDKKKSQEIIRRKTKYRFLMASNNKIPPYEREYVFKREQLNQIVDDGCFFWSDKLLQIYARC
What is the function of this protein?
Endonuclease that cooperates with the MRX complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of SPO11 from the break sites and ensuring both resection and intrachromosomal association of the broken ends.  Required for proper recovery from checkpoint-mediated cell cycle arrest after DNA damage.  MRX complex and SAE2 remove a small oligonucleotide(s) from the DNA ends to form an early intermediate which is rapidly processed by EXO1 and/or SGS1 to generate extensive tracts of single-stranded DNA that serve as substrate for RAD51.  Plays a transitional role in the dissociation of MRE11 from, and the recruitment of RAD52 to, repair foci.  Ensures that both ends of a DSB participate in a recombination event and impairs the formation of palindromic structures in the genome.  With TEL1, promotes microhomology-mediated end joining (MMEJ) but inhibits non-homologous end joining (NHEJ), likely by regulating MRE11-dependent ssDNA accumulation at DNA break.  SAE2 and MRX are particularly important for removal of hairpins, bulky adducts and other irregular end structures.  Facilitates telomere length reequilibration and subsequent checkpoint switch off.  Involved in homing efficiency of VMA1 intein VDE and in repair of transposon excision sites.
What are the official names of this protein?
DNA endonuclease SAE2, Completion of meiotic recombination protein 1, Sporulation in the absence of SPO11 protein 2.
What is the protein family that this protein belongs to?
Belongs to the COM1/SAE2/CtIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Accumulates in foci at the precise time when MRE11 foci disassemble and RAD52 foci assemble (PubMed:18670132). Remains associated with DSBs along with MRE11 in nuclease-deficient cells (PubMed:18670132).
Protein: PPA6_BOVIN
Sequence: MISRVFKLRMWAPVGVLTSLTYCLHQRRVALAEPGGADQQNPVDRNLLELKMVQVVFRHGARSPLKPLPQEDQQVEWKSQLLEVPPQTQLEYTVTNLAGGPKPHSPFDSQYHETTLKGGMFAGQLTKVGMEQMFALGERLRKNYVEDIPFLSPTFNPLEVFIRSTNIYRNLESTRCLLAGLFQRQKEGPIVIHTDEASSEVLYPNYQYCWNLQKRTRGRRQAASLQPGISEDLKKVKEGMGIASSDEVDFLVLLDNMAAEQVHSLPSCPTLKRFAWMIEQRAVDTALYILQWEDREGLQMAVGPFLHILESNLLKVVDPATPPSKTRKLYLYAAHDVTLMPLLMTLGIFDHKWPPFAVDLTMELYQHRESKEWFVQLYYRGKEQVPKGCPDGLCPLDKFLNTISVYTLSPEKYHMLCSEAQMMGLGNGE
What is the function of this protein?
Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol.  Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.
What are the official names of this protein?
Lysophosphatidic acid phosphatase type 6.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y3444_MYCBO
Sequence: MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVIQGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMATAIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG
What are the official names of this protein?
Uncharacterized oxidoreductase Mb3444c.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: QSOX1_ORYSJ
Sequence: MAAAAVARRVVLVLVLAAASLAAAPRGAAARSLGGREGPGEVDADAAVDLNATNFDAFLKASLEPWAVVEFFAHWCPACRNYKPHYEKVAKLFNGRDAAHPGLILMARVDCASKVNIDLCNRFSVDHYPFLLWGPPTKFASAKWDPKQENNEIKLIDDGRTAERLLKWINNQMKSSFSLEDKKYENENMLPKNASDPEQIVQAIYDVEEATAQALQIILERKTIKPKNRDSLIRFLQILVARHPSKRCRRGSAELLINFDDHWSSNLSLSSQEGSKLLESVAEENHWICGKEVPRGYWLFCRGSKSETRGFSCGLWVLMHSLTVRIGDGESQSTFTSICDFIHNFFICEECRKHFYEMCSSVSAPFRTARELSLWLWSTHNKVNMRLMKEEKDMGTGDPLFPKVTWPPNQLCPSCYRSSKVTDGAVDWNEDAVYQFLVNYYGKKLVSSYKETYMESLQQQEKKIVSEDSSISNAASVPIGAALGVAIASCTFGALACFWRAQQKNRKQRKNWN
What is the function of this protein?
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.  May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).
What are the official names of this protein?
Sulfhydryl oxidase 1, Quiescin-sulfhydryl oxidase 1, OsQSOX1.
What are the subcellular locations of this protein?
Secreted.
Protein: EBPS_STAAW
Sequence: MSNNFKDDFEKNRQSIDTNSHQDHTEDVEKDQSELEHQDTIENTEQQFPPRNAQRRKRRRDLATNHNKQVHNESQTSEDNVQNEAGTIDDRQVESSHSTESQEPSHQDSTPQHEEEYYNKNAFAMDKSHPEPIEDNDKHETIKEAENNTEHSTVSDKSEAEQSQQPKPYFATGANQANTSKDKHDDVTVKQDKDESKDHHSGKKGAAIGAGTAGVAGAAGAMGVSKAKKHSNDAQNKSNSDKSNNSTEDKVSQDKSKDHHNGKKGAAIGAGTAGLAGGAASKSASAASKPHASNNASQNHDEHDNHDRDKERKKGGMAKVLLPLIAAVLIIGALAIFGGMALNNHNNGTKENKIANTNKNNADESKDKDTSKDASKDKSKSTDSDKSKEDQDKATKDESDNDQNNANQANNQAQNNQNQQQANQNQQQQQQRQGGGQRHTVNGQENLYRIAIQYYGSGSPENVEKIRRANGLSGNNIRNGQQIVIP
What is the function of this protein?
Promotes binding of soluble elastin peptides and tropoelastin to S. aureus cells although it is not able to promote bacterial adherence to immobilized elastin and, therefore, is not a microbial surface component recognizing adhesive matrix molecule (MSCRAMM).
What are the official names of this protein?
Elastin-binding protein EbpS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAA11_DANRE
Sequence: MVRISEDLIRRRAEHNNGEIFSLEELSLHQQDIQRIEHIHKWCRDLKILYLQNNLIPKIENVGRLKKLEYLNLALNNIEVIENLEGCESLQKLDLTVNFVGRLSSVETLKHNLHLKELYLVGNPCAEYQGYRQYVVATVPQLQSLDGKEISRAERIQALQELDAVRTRVLQQETKYLEEREKQKSNANEHPEINQSLSESQNGTQQYPESSSKTHTEAEDEEREFWEKPCPFTPESRLEAHRHLEEKRRANEKEKEKPKTKTPRTLITPDGRVLNVNEPKLDFSLFEDENNCLLLDLHVYRHMDSSLLDVDVQPMYVRVTVKGKVFQLVLPAEVKPDSSSAQRSQTTGHLLLILPLANEDVKPKKRTIRPTSVTSNQNNKKDTRAAPRRELLEVDPGLAGSLANIVPKGQESSHNPQRCGLEERPVSKDFVDDPEVPPLM
What is the function of this protein?
Plays a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube.  Required for establishing left-right asymmetry of the body plan; controls cell fate and convergent extension (CE) movements during gastrulation, respectively, via the Wnt and the planar cell polarity (PCP) signaling pathways.  Required for the proper development of renal glomeruli and tubules.
What are the official names of this protein?
Dynein axonemal assembly factor 11, DNAAF11, Leucine-rich repeat-containing 6-like protein, Leucine-rich repeat-containing protein 6, Protein tilB homolog, Seahorse.
What is the protein family that this protein belongs to?
Belongs to the tilB family.
What are the subcellular locations of this protein?
Cytoplasm. Dynein axonemal particle. Cell projection, cilium. Note=Localized to cytoplasmic puncta in ciliated cells. In the semicircular canal, localized to kinocilia.
Protein: AATC_HUMAN
Sequence: MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
What is the function of this protein?
Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944).  Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system.  Acts as a scavenger of glutamate in brain neuroprotection.  The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis.  Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide.  Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST).  Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.  In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456).
What are the official names of this protein?
Aspartate aminotransferase, cytoplasmic, cAspAT, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NT8F2_RAT
Sequence: MAPYHIRQFQDRDHRRVLDLFSRGMEEHVPAAFYHVLTLPHSLLLFPGVPVTIILVSGSWLLATVYSFLFLLCLRLIFWVSCRNYVAKCLQADLADITKSYLNAHGSFWVAESGGQVVGIVAALPVKEPPSGRKQLQLFRLSVSSQHRGQGIAKALVRIVLQFARDQGYTDVVLVTGNMQYSAISLYQGMGFQKTGHYFVSIAKRLIGLSIFHFTYSLPSVWEPRM
What is the function of this protein?
Probable acetyltransferase (Probable).  Has no detectable histone acetyltransferase activity towards histone H3 or H4.
What are the official names of this protein?
N-acetyltransferase family 8 member 2, Camello-like protein 2, N-acetyltransferase-like protein CML2.
What is the protein family that this protein belongs to?
Belongs to the camello family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: XERIC_ARATH
Sequence: MGLSSLPGPSEGMLCVILVNTALSISIVKGIVRSFLGIVGISLSPSSSSPSSVTVSSENSSTSESFDFRVCQPESYLEEFRNRTPTLRFESLCRCKKQADNECSVCLSKFQGDSEINKLKCGHLFHKTCLEKWIDYWNITCPLCRTPLVVVPEDHQLSSNVW
What is the function of this protein?
Function on abscisic acid homeostasis at post-translational level, probably through ubiquitin/proteasome-dependent substrate-specific degradation.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase XERICO, RING-type E3 ubiquitin transferase XERICO.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL15_ECOLC
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEIRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PAQR8_HUMAN
Sequence: MTTAILERLSTLSVSGQQLRRLPKILEDGLPKMPCTVPETDVPQLFREPYIRTGYRPTGHEWRYYFFSLFQKHNEVVNVWTHLLAALAVLLRFWAFAEAEALPWASTHSLPLLLFILSSITYLTCSLLAHLLQSKSELSHYTFYFVDYVGVSVYQYGSALAHFFYSSDQAWYDRFWLFFLPAAAFCGWLSCAGCCYAKYRYRRPYPVMRKICQVVPAGLAFILDISPVAHRVALCHLAGCQEQAAWYHTLQILFFLVSAYFFSCPVPEKYFPGSCDIVGHGHQIFHAFLSICTLSQLEAILLDYQGRQEIFLQRHGPLSVHMACLSFFFLAACSAATAALLRHKVKARLTKKDS
What is the function of this protein?
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432).  Seems to act through a G(i) mediated pathway (PubMed:23763432).  May be involved in oocyte maturation (By similarity).  Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).
What are the official names of this protein?
Membrane progestin receptor beta, mPR beta, Lysosomal membrane protein in brain 1, Membrane progesterone P4 receptor beta, Membrane progesterone receptor beta, Progesterone and adipoQ receptor family member 8, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D.
Protein: RSMG_SHEHH
Sequence: MLSAQLNDYLAEVGLTATEQQKKQLVDFVGMLNKWNKAFNLTSVRDPEQMLIRHIMDSLVVSPHLKGSRFIDVGTGPGLPGIPLAILNPDKEFVLLDSLGKRIRFQKQVQFELGINNISSIESRVEAYQPEELFDGVLSRAFASIQDMLHWCHHLPKADGCFYALKGQLSEDEMAQLPAGFVVTDIFELKVPKLDEQRHLLRVIKQD
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.