PharMolix/UniProtQA huggingface dataset:
Protein: DTD_STRM5
Sequence: MLVLIQRASQAAVHVDDEVVGQIGPGLLALVGMEPGDTEAQLQRMAERLLGYRVFADEAGKMNRSLRDTGGGLLLVSQFTLAADTRSGMRPSFTSAAPPAEAEQGFNRFVEICRENHAPGVETGRFGAHMVVSLVNDGPVTFLLRP
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_BORHD
Sequence: MNRITNNKTIWIKPKYVEKKWYVIDASDKVLGRIATEAVKILRGKHKPYYTPHQDLGDNVIIVNASKIRLTGKKYSQKIYYRHSRYPGGLYSDTFRTLSERKPTAPLEIAIKGMLPKGPLGRELFRNLKVFADSNHTLKAQNLYKLEAN
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PCNA_SOYBN
Sequence: SSTGFSLQAMDSSHVALVALLLRSEGFEHYRCDRNISMGMNLNNMAKMLKCAGNDDIITIKADDGSDTVTFMFESPTQDKISDFEMKLMDIDSEHLGIPEAEYHAIVKMPSSEFARICKDLSSIGDTVVISVTKEGVKFSTKGDIGTANIVCRQNTSVDKPEEATVIEMNEPVSLTFALRYMNSFTKATPLSNTVTISLSNELPVVVEYKIAEMGYVRFYLAPKIEEDEEDTKPQV
What is the function of this protein?
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
What are the official names of this protein?
Proliferating cell nuclear antigen, PCNA, Cyclin.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTH_PELUB
Sequence: MLLFVGLGNPTPDSENNRHNIGFKLIDALNQKFGLSKQKPKFKGLLTTGNVEDKKVYAIKPLTFMNNSGICIRELIEYFKIDAEDVIVFHDDLDLEFGKVKAKFAGSSAGHNGIESIDKFIGKDYSRVRIGIGRPKTKADVADHVLKDFDEDEMIQLEKITKNIIDSMAILIDKKLDLFSSTVNNK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WECF_SALDC
Sequence: MTVLIHVLGSDIPHHNHTVLRFFNDTLAATSEHAREFMVAGEDNGFTESCPALSLRFYGSKKALAQAVIAKAKANRRQRFFFHGQFNTSLWLALLSGGIKPAQFYWHIWGADLYEVSNGLKFRLFYPLRRIAQGRVGCVFATRGDLSYFARQHPNVRGELLYFPTRMDPSLNAMAKECQRAGKLTILVGNSGDRSNQHIAALRAVYQQFGDTVNVVVPMGYPANNQAYIDEVRQAGLALFSAENLQILSEKMEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQADIPCVLNRDNPFWQDMAEQHLPVLFTTDDLNEQVVREAQRQLASVDKSGITFFSPNYLQPWHNALRIAAGEAE
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CINAL_THEM4
Sequence: MKKSIILAIGNELVEGIIIDTNSKYISKKLLEIGYKTVAINTLPDDLEILVEEIRDSLKKADLLITTGGLGPTEDDLTREAISKTVGKELIFNEKLYNSILKKVKEFHSEIPKNIEKQAWVINGARIIENPVGTAPGQILQIGEKQIIILPGPPVEMKPIFEESLKFLEKFEKIYQKRIKTLGIPEAILVEKYKDIIYKYKDVNVATLASHISGVELRFTGKKEKVDEIVKLLKEKLSDHIYALDNETIEEVVFKKLEGKSVSFAESCTGGLISAKFVSIPGISKVFKGAIVAYSNKVKEKVLNVNKNTIQKYGAVSKECVMEMAKEVSYFLDTDYAVAVSGIAGPTGGTKEKPVGTVWICAYKRENDYYLVEKFFFRGNREIIREKSALNAFNLLRRILS
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: EXP11_ORYSJ
Sequence: MELLRLLAVAAVAAMAAEVAAGGDSGWSSGSATFYGGSDASGTMGGACGYGNLYSAGYGTSTAALSTALFNNGQSCGACFEVRCGGGGSCLAGTVAVTATNLCPPNYALAGDAGGWCNPPRPHFDMAEPAFTRIAQARAGVVPVQYRRVACAKQGGIRFTITGHSYFNLVLVTNVGGAGDVTAVSVKGSRSGWQAMSHNWGANWQNGANLDGQPLSFRVTASDGRTVTSDNVAPSGWSFGQTFSGGQF
What is the function of this protein?
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans.  No enzymatic activity has been found.  May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
What are the official names of this protein?
Expansin-A11, Alpha-expansin-11, OsEXP11, OsEXPA11, OsaEXPa1.25.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: ATPG_LYSSC
Sequence: MVNLREIKGRINSTKSTKQITKAMQMVSSSKLRRAEQNAKAYVPYMEKIQDVVGAIASGTKDSGHPMLTARPVKKTAYLVIGSDRGLAGAYNSSILRQVQRTIDERHKSKDEYVILAIGRVVRDYFVKRDHNVISDVVGLPDQPTFADIKEIARNAVGMFIDGTYDQLYMYYNHFVSAIANEVTEKKLLPLTDLAPPSSNASYEFEPSGEAILEVLLPQYAESLVYGALLDGKASEHASRMTAMKNATDNASDLISDLSLQYNRARQAAITQEITEIVGGAAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SCNNG_RAT
Sequence: MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCMNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNKENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWHKAKDWWARRQTPPSTETPSSRQGQDNPALDTDDDLPTFTSAMRLPPAPGSTVPGTPPPRYNTLRLDRAFSSQLTDTQLTNEL
What is the function of this protein?
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride (PubMed:9118951, PubMed:8188647).  Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells (PubMed:9118951, PubMed:8188647).  Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus (By similarity).  Controls the reabsorption of sodium in kidney, colon, lung and sweat glands.  Also plays a role in taste perception (By similarity).
What are the official names of this protein?
Amiloride-sensitive sodium channel subunit gamma, Epithelial Na(+) channel subunit gamma, Gamma-ENaC, Gamma-NaCH, Nonvoltage-gated sodium channel 1 subunit gamma, SCNEG.
What is the protein family that this protein belongs to?
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells.
Protein: SNA64_LYCMC
Sequence: MKILFLIILTAFFIGVHCKHGYPIIRAGRDKGCKVSCVINNQYCDTECKQLKGRRGYCYFWRLACFCEYLPDYVPTWSRATNKCKAK
What is the function of this protein?
Binds voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Neurotoxin LmNaTx64.1.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OPAD_NEIGO
Sequence: AGEDHGRGPYVQADLAYAYEHITHDYPEPTGTKKDKISTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWNNNKYSVNIKELLRNDNANSGGSHLNIKTRKTEHRENGTFHAASSLGLSAVYDFDTGSRFKPYIGMRVAYGHVRHQVRSVQQETIAVTTYPQNAASSVTTNAPIRKLPHHESRSISSLGFGAVAGVGIDITPNLTLDAGYRYHNWGRLENTRFKTHEASLGVRYRF
What is the function of this protein?
Implicated in a number of adherence functions.  OPA proteins are implicated in pathogenesis and are subject to phase variation.
What are the official names of this protein?
Opacity protein opA59.
What is the protein family that this protein belongs to?
Belongs to the opacity porin family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: GREA_BACC1
Sequence: MATEKTYPMTQEGKQKLENELEDLKTVKRKEVVERIKIARSFGDLSENSEYDAAKDEQAFVEGRITQLENMIRNAVIITDNGEESTVVTLGKTVTFKELPDGDEEAYTIVGSAEADPFEGRISNDSPIAKSLLGKQIGEKVAIQTPGGEMQVEIISVK
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: NDP2_ARTSK
Sequence: SIPASQKANLGNQMIMAVACYQN
What are the official names of this protein?
NADP phosphatase 2, NADP phosphatase II.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_BRUO2
Sequence: MVTVLNTVNQSGRLRHPEKAHRPDNEVLKKPDWIRVKAPVSRGYGETREIVRSNKLVTVCEEAGCPNIRECWEKKHATFMIMGEICTRACAFCNISTGIPNALDPNEPENIAKAVKQMGLTHVVITSVDRDDLADGGAHHFAEVIKAVREAAPATTIEILTPDFLRKEGALEIVVKARPDVFNHNLETVPSKYLKVRPGARYFHSIRLLQRVKELDPTIFTKSGIMVGLGEERNEILQLMDDLRSADVDFMTIGQYLQPTRKHHPVIRFVKPDEFKSFETIGKTKGFLLVASSPLTRSSHHAGEDFAKLKAAREALYASRAS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBD2A_RAT
Sequence: MEDTPERTPSSESIQPPGLAREPEVTSPGDSEGCARPLDPAPKKLCGYLSKFGGKGPIKGWKCRWFFYDERKCHLYYSRTAQDANPLDSIDLSSATFDCKADAEEEGTFEIKTPSRVITLKAATRQVMLYWLQQLQMKRWEFHNSPPALPATPAAALTENGPTLHLKLEQEEAELEEFLCPVKTPPGLVGTAAALQPVPAMPSALQNISLKHLGTEIQNTMYNIRGNKQAQATAHGPPVEESSQSAEPQRGEQPLISDPSIPEKEPEDPPKSAPRSCVPSGPMQKPKRQSNTFPFFSDGLARSRTAQEKVVALEQQVLMLTKELKSQKELVIILHKALEAAQQEKRASSAYLAATEDRDRLELVRHKVRQIAELNQRVEALEQDRERLVHEAGLREQQVQALQQHVQLLMDKNQAKQQVICKLSQKLTEDLAQPQPADATNGDFLSQQERLEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEAAGAEPGDFPELLQQLVQEALQWEAGEASDSVGLSPVSEYDDYGFLTVPDYEVEDLKLLAKIQALEVRSHHLLALEAVERPLRDRWATLTELMPSAELKQLLRAGVPREHRPRVWRWLVHRRVQHLHSSGCYQELLARGRACEHPAARQIELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQRHVDLSLITFNWFLVIFADSLISDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILRLQDSLEIYQYLRFFTKTICDSRKLTSIAFNDMNPFPMKQLRQLRAAHRERLEAELRELELLKAEYLERRASRGRAVPEGCVSEDEGEGDS
What is the function of this protein?
Acts as GTPase-activating protein for RAB7A.  Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity).
What are the official names of this protein?
TBC1 domain family member 2A.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle. Cell junction.
Protein: BR1C_ODOJI
Sequence: FLPAVLRVAAKVVPTVFCLISKKC
What is the function of this protein?
Has antibacterial activity against E. coli ATCC 25992 (MIC=49 uM), E. coli CIB 84492 (MIC=25 uM), S. aureus ATCC 25923 (MIC=6 uM) and S. aureus CIB 85462 (MIC=3 uM).
What are the official names of this protein?
Brevinin-1JDc.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: CAH1_MACMU
Sequence: MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSEAKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSSNEYGSEHTVDGVKYSSELHIVHWNSAKYSSLAEAVSKADGLAVIGVLMKVGEANPKLQKVLDALHAIKTKGKRAPFTNFDPSTLLPSSLDFWTYSGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGSNPVPIQRNNRPTQPLKGRTVRASF
What is the function of this protein?
Catalyzes the reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase I, CA-I.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSA_PHOLL
Sequence: MPDVFTHPDKTLDTQGLRCPEPVMMVRKTVRHMEAGQMLLILADDPATTRDIPSFCRFMEHQLVAQETEQMPYRYLVRKKESQL
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEBH_THEKO
Sequence: MEFLYTYETLKLEFPLVEPEKARFILLGVPFDGTTSYKAGARFGPTLIRQATLNLESYILDYDLDIAELPIADIGDIAVVAGDPRKTADRVRETLEELKKANPKAIPILLGGEHSQTLGAVEALKPASYVVFDAHLDLRNSYEDNPYNHACVARRISELGVKEAIFGIRSGTKEEVDFARERDIPWVHARDYSFDAFVDLVEALPEPVYLSIDIDVFDLSMVPSTGTPEAGGLRFWEVVEAIEWLVEKKEIAGFDIMEVAGEKLGDPTALTAAKLLFYSIGAMAKFGR
What is the function of this protein?
Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions.  It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively.  Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to yield spermidine and urea.  It can also use agmatine to yield putrescine.
What are the official names of this protein?
N(1)-aminopropylagmatine ureohydrolase, Agmatinase, Protein SpeB homolog.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BORA_XENLA
Sequence: MGDVRTQLTPETPGRAAILNPFESPSDYCSLHEPFVSSPSVFKPSKSAATPQQFRWSIDQLAAINPIEIDAEDIHRQALYLSRAKTDKETEERRQKAIEEFFTKRTIVPSPWTQHEGKPAAPFHSTKCADLIHESPVGRVQAVQSGKSTVGCQTHLSLPVDFNLEKVLGEYFRAEETADQSQDNLSSSSLRRKLFLDGHASGSECSSPSSPPQEGPYYDPPAALGVLCSIDLSPVRCRSPTQTPSSGQFSSSPIQGGRRAFSLGSITSPTFLEKSPASVTSPSFSPIAINLGKTPDAEQKRLIFPSPETLSASTSMVNAFTRNPYIEGCSPIKSIFQIKSRSCRGNAPHRTSLFQIPFALEPHSDDKENSPPSSIKSPEGDLSSLFHQLENIVPDGHVMMGGEPIVSPTVYMQQEYLQSEELKENDTVEMVEPVEIEEEHSWPKETVATDNIPMASFMTGITFSGESSHMCMSPLAESSVIPCENSSIQVDSGYNTQTYGSCIMDGIGAETTYKENDTHISDIQNKCQHFKVKDISSVDCKNQLLEPESPEFQHSTQKSQNKLARYSLNSGMWKLTGDGAINRLNKNGGVQSPPRTLNPKSLSHFLQ
What is the function of this protein?
Required for the activation of aurka at the onset of mitosis.
What are the official names of this protein?
Protein aurora borealis.
What is the protein family that this protein belongs to?
Belongs to the BORA family.
Protein: C2TA_MOUSE
Sequence: MNHFQAILAQVQTLLSSQKPRQVRALLDGLLEEELLSREYHCALLHEPDGDALARKISLTLLEKGDLDLTFLSWVCNSLQAPTVERGTSYRDHGDHSLCATMDLGSPEGSYLELLNSDADPLHLYHLYDQMDLAGEEEIELSSEPDTDTINCDQFSKLLQDMELDEETREAYANIAELDQYVFQDTQLEGLSKDLFIEHIGAEEGFGENIEIPVEAGQKPQKRRFPEEHAMDSKHRKLVPTSRTSLNYLDLPTGHIQIFTTLPQGLWQISGAGTGLSSVLIYHGEMPQVNQVLPSSSLSIPSLPESPDRPGSTSPFTPSAADLPSMPEPALTSRVNETEDTSPSPCQEGPESSIKLPKWPEAVERFQHSLQDKYKALPQSPRGPLVAVELVRARLERGSNKSQERELATPDWTERQLAHGGLAEVLQVVSDCRRPGETQVVAVLGKAGQGKSHWARTVSHTWACGQLLQYDFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPDRVLLILDAFEELEAQDGLLHGPCGSLSPEPCSLRGLLAGIFQRKLLRGCTLLLTARPRGRLAQSLSKADAIFEVPSFSTKQAKTYMRHYFENSGTAGNQDKALGLLEGQPLLCSYSHSPVVCRAVCQLSKALLEQGTEAQLPCTLTGLYVSLLGPAAQNSPPGALVELAKLAWELGRRHQSTLQETRFSSVEVKTWAVTQGLMQQTLETTEAQLAFSSFLLQCFLGAVWLAQCNEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHCLGALVEPAVAAVADRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPGHLSFLGTRLTPPDVYVLGRALETASQDFSLDLRQTGVEPSGLGNLVGLSCVTSFRASLSDTMALWESLQQQGEAQLLQAAEEKFTIEPFKAKSPKDVEDLDRLVQTQRLRNPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETLAMWTPTIPFGVQEHLQQLDARISLR
What is the function of this protein?
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter.  No DNA binding of in vitro translated CIITA was detected.  May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both.  Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.  Also mediates enhanced MHC class I transcription, the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes (By similarity).  Activates CD74 transcription (By similarity) (PubMed:32855215).  Exhibits intrinsic GTP-stimulated acetyltransferase activity.  Exhibits serine/threonine protein kinase activity: phosphorylates the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (By similarity).
What are the official names of this protein?
MHC class II transactivator, CIITA.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Note=Recruited to PML body by PML.
Protein: DPOL_WHV6
Sequence: SKRYSPPLNYEKSDFSSPGVRGRITRLDNNGTPPQCLWRSFYNTKPCGSYCIHHIVSSLDDWGPCTVTGDVTIKSPRTPRRITGGVFLVDKNPNNSSESRLVVDFSQFSRGHTRVHWPKFAVPNLQTLANLLSTNLQWLSLDVSAAFYHIPISPAAVPHLLVGSPGLERFTTCLSSSTHNGNDSQLQTMHALCTRHVYSSLLLLFKTYGRKLHLLAHPFIMGFRKLPMGVGLSPFLLAQFTSALASMVRRNFPHCVVFAYMDDLVLGARTSEHLTAIYSHICSVFLDLGIHLNVNKTKWWGNHLHFMGYVITSSGVLPQDKHVKKLSRYLRSVPVNQPLDYKICERLTGILNYVAPFTLCGYAALMPLYHAIASRTAFIFSSLYKSWLLSLYEELWPVVRQRGVVCTVFADATPTGWGIATTCQLLSGTFAFPLPIATAELIAACLARCWTGARLLGTDNSVVLSGKLTSFPWLLACVANWILRGTSFCYVPSALNPADLPSRGLLPVLRPLPRLRLRPQTSRISLWAASPPVSPRRPVRVAWSSPVQTCEPWIPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery (By similarity).
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: RUVB_STAA8
Sequence: MNERMVDQSMHSEETDFELSLRPTRLRQYIGQNSIKSNLEVFIKAAKLRHEPLDHVLLFGPPGLGKTTLSNIIANEMEVNIRTVSGPSLERPGDLAAILSGLQPGDVLFIDEIHRLSSVVEEVLYPAMEDFFLDIIIGKGDEARSIRIDLPPFTLVGATTRAGSLTGPLRDRFGVHLRLEYYNESDLKEIIIRTAEVLGTGIDEESAIELAKRSRGTPRVANRLLKRVRDFQQVNEDEQIYIETTKHALGLLQVDQHGLDYIDHKMMNCIIKQYNGGPVGLDTIAVTIGEERITIEDVYEPFLIQKGFLERTPRGRKATPLAYEHFAKSNEERE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: VATB2_ACEAT
Sequence: MASAEVFKANVEAVTRDYICEPRIEYRTVGGVSGPLVVVELVKRPKFAEIVNIRLGNGTSRRGQVLEVDGNRAVVQVFEGTSGIDNRNTTLQFTGEVLSTPVSKDMLGRVFNGSGKPIDGGPTVLAEAYLDIQGSSINPSERTYPEEMSQTGVSTIDVMNSIARGQKIPLFSAAGLPHNDIAAQICRQAGLVRQKAQDSMIDAGREEEEFAIVFAAMGVNMETAHYFKQDFEENGSMEKTVLFLNLANDPTIERIITPRIALTTAEYLAYECGKHVLVILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRIEGRKGSITQLPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNIQIYPPINVLPTLSRLMKSAIGEGMTRKDHSEVSNQLYDNYAIGKDVAAMKAVVGEEALSSEDLLYLEFLDKFERKFVNQGHYEARTIFDSLDLAWTLLRLFPKELLRRITAKTLEKMYERSES
What is the function of this protein?
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase subunit B 2, V-ATPase subunit B 2, Vacuolar proton pump subunit B 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.