PharMolix/UniProtQA huggingface dataset:
Protein: FBLN1_HUMAN
Sequence: MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF
What is the function of this protein?
Incorporated into fibronectin-containing matrix fibers.  May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM).  Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.  Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor.  May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots.  Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
What are the official names of this protein?
Fibulin-1, FIBL-1.
What is the protein family that this protein belongs to?
Belongs to the fibulin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: MOAC_BURA4
Sequence: MSGLTHFDAAGHAHMVDVGGKQETQRIAIARGTIRMLPATFALIRDGKAKKGDVLGVARIAAIQGAKRTAELIPLCHPLALTRVAVDFELDDALPGVHCVAQVETFGRTGVEMEALTAVQVGLLTVYDMCKAVDRGMVITEVSVREKRGGKSGDWKAEDTAG
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: NMNA2_XENTR
Sequence: MAETTKTHVILLACGSFNPITKGHIQMFERARDYLHKTGKFIVIGGIISPVHDSYGKQGLVSSRHRLNMCQLAVQNSDWIRVDPWECYQDTWQTTCSVLEHHRDLMKRVTGCILSNVNTPSVTPVIGQSLNQSTQPVYQNSNLSNKPTAVRILGKVGEGLSRMCCVRPNLQRVTFVDENANLGTVMRYEEIELRILLLCGSDLLESFCIPGLWNESDMEVIVGDFGIVVVPRDSVEPEQIINHSSLLRKYKNNILTVKDDSNHPMAVVSSTKSRLALQHGDGHVVDYLAQPVIDYVLKSQLYINTSG
What is the function of this protein?
Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor.  Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons.  Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP.  Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency.  Also catalyzes the reverse reaction, i. e.  the pyrophosphorolytic cleavage of NAD(+).  For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively.  Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16.
What are the official names of this protein?
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2, NMN/NaMN adenylyltransferase 2, Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus.
Protein: ACSF1_THEVB
Sequence: MVNTVAKPEFEELRPGIKAPAKETILTPRFYTTDFEAMANMDITENKAELEAILEEFRCDYNRHHFVRDEEFEQSWDHIDGETRRLFIEFLERSCTAEFSGFLLYKELSRRLKDRNPLLAECFALMSRDEARHAGFLNKAMADFNLSLDLGFLTQHRSYTYFEPEFIFYATYLSEKIGYWRYITIYRHLEKHPEHRIYPIFRFFENWCQDENRHGDFFDAVMRAQPQMLDRPRTFWQKIKEIPLSLSGKKWARYFMVCWVPPKLWCRFFLLSVFATMYLNDLQRAKFYTALGLDAREYDREVIAKTNETAGRVFPVILDVDHPEFYQRLERCVENNAKLTEIAKQNGGFLKKLPLYLSNVWQMIKLFLIPAKEPTRVAVR
What is the function of this protein?
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis.  Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).
What are the official names of this protein?
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1, Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1.
What is the protein family that this protein belongs to?
Belongs to the AcsF family.
Protein: RL10_SYNSC
Sequence: MGRTLENKQQIVGELKELLADAELALVLDFKGLSIKEMSDLRDRLRASDSVCKVTKNTLMRRAIDGDSNWASLDSLLTGTNAFVLVKGDVGAGVKAVQTFQKELKKSETKGGLFEGKLLSQDEIKAIADLPSKEQLMAQIAGAINAVATKVAVGINEVPSGMARALKQHAEGGEG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: DEF_STRMU
Sequence: MSAIKTITKASHLIDMNDIIREGHPTLRAVAQDVTFPLNEDDIILGEKMLQFLKNSQDPVTAEKMELRGGVGLAAPQLDISKRIIAVLIPNPEDKDGNPPKEAYALKEVMYNPRIIAHSVQDAALADGEGCLSVDRVVEGYVIRHSRVTIEYYDKNSDKKKLKLKGYQSIVVQHEIDHTNGIMFFDRINEKNPFEIKEGLLLIE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: DAM_BPHC1
Sequence: MMTKSNTKKSDKDLWATPWWVFHYAEQYFNIKFDLDTCAMEHNTKVKNFITPEQNTLTADWQGRYCWMNPPYSNPLPFVLRAISQSVLHNKTVVMLLNVDGSTKWFDMCVRNAKEIVYITNSRIPFINNETGEETDQNNKPQMLVLFEPKAPYGSLKSSYVSLHEMKEKGMLQ
What is the function of this protein?
Methyltransferase that methylates adenine residues in the ssDNA and dsDNA sequence 5'-GATC-3' (PubMed:10581668).  May prevent degradation of viral DNA by the host restriction-modification antiviral defense system (Probable).
What are the official names of this protein?
DNA N-6-adenine-methyltransferase, DAM, ORF13, Orphan methyltransferase M.HinHP1Dam, M.HinHP1Dam.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: TXSS3_PSETR
Sequence: LFGNIIDKLREKIKKYCNKENLDKACSKL
What is the function of this protein?
This heterodimer may have anti-inflammatory properties, since the myrmexin complex (composed of 6 SS-LS heterodimers) inhibits carrageenin-induced edema in a dose-dependent manner (after subcutaneous injection into rats).
What are the official names of this protein?
U1-pseudomyrmecitoxin-Pt1 subunit SS3, U1-PSDTX-Pt1 subunit SS3, Myrmexin IV subunit SS3/Myrmexin VI subunit SS3, U1-pseudomyrmecitoxin-Pt1d subunit SS3/U1-pseudomyrmecitoxin-Pt1f subunit SS3, U1-PSDTX-Pt1d subunit SS3/U1-PSDTX-Pt1f subunit SS3.
What is the protein family that this protein belongs to?
Belongs to the myrmexin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1856_LISMH
Sequence: MVWDATNIFLFAANILTVLYILYNDAVIPLWKGKTVLSVKLRSRGRWDGYIFVGIIVLLFVSNTFFREGPFSTSVLLGIMGVLFIYICFFRSSKAVFKESGLFYALLFFPYAKIERMNLSEDGVLVIETNRQRLMLFARSEKDLEKMLAVFTTYS
What are the official names of this protein?
UPF0266 membrane protein LMHCC_1856.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURA_METCA
Sequence: MDKLLIGGGRPLSGELRISGAKNAALPVLAATLLSDGPVTVGNVPHLHDITTTMELLGRMGLNLMVDEKLNIEVDPSTIQNFFAPYELVRTMRASILVLGPLLARFGRAEVSLPGGCAIGTRPVNLHLEGLAAMGAEINVRNGYIYAEAKRLKGCRLVLDQVTVTGTENLMMAAALADGVTIIENAAREPEVVDLANFINAMGGKVSGAGTDVLQIEGVDSLSGAGLNYRILPDRIETGTYLVATAMTGGRVKLKGTRPDLLDAVLAKLEEAGAEITLGDDWIELDMKGRRPQAVSLHTAPYPAFPTDMQAQFTAMNAIAEGVGVITETVFENRFMHVQEMQRMGADIKLESNTAIVKGVSRLTGAPVMATDLRASASLVLAGLVAEGQTKVDRIYHIDRGYECIEEKLAQLGAEIRRVPN
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B3GA1_CANLF
Sequence: MPKRRDILAIVLIVLPWTLLVTVWHQSTIAPLLTTHKGEPLTDSRREAAPGADPREYCMSDRDIVEVVRTEYVYTRPPPWSDTLPTIHVVTPTYSRPVQKAELTRMANTLLHVPNLHWLVVEDAPRRTPLTARLLRDTGLNYTHLHVETPRNYKLRGDARDPRIPRGTMQRNLALRWLRETFPRNSSQPGVVYFADDDNTYSLELFEEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVGWKTVFDPHRPFAIDMAGFAVNLRLILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPKAANCTKILVWHTRTEKPVLVNEGKKGFTDPTVEI
What is the function of this protein?
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins.  Can also play a role in glycosaminoglycan biosynthesis.  Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule.  Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin.  Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
What are the official names of this protein?
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, Beta-1,3-glucuronyltransferase 1, Glucuronosyltransferase P, GlcAT-P, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, GlcUAT-P.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 43 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.
Protein: MLTF_ALTMD
Sequence: MQSQDYKKRLKLQIIIILSIAVMSCGVPNVPTALSSLLERESIRVGTVYGAGTFYNGAEGPQGFEYELLAGFADYLGVTLDLYPFYSYEVMLEQLEEGNLDIVATGDAVTPALKRRFAYGPAYQRVEQELVFQAGATRPRDLAELDSPIIAVAGSSQAHLLSNLFKRLSEEEDEAVQTQLITTEDSDSEELLQQVANGDIAYTVADSNRLALQRRRYPNLAVARTLNENMPMAWALPLQQDDSVKAALIEYFGTVHQSGWFTVLEDKYFGHIRQFDYVDSRAFNYAAESTLTQYKSLFQKYAGDLDWRLLAAMSYQESHWNSDAISRTGVRGLMMLTLATASDWNVDDRTDPEQSIRGGSRYFASLLNRIPARISEPDRTWMAMASYNIGMGHLEDARILTEQQGGNPDLWVDVKRRLPQLRQKKYYRTTRYGYARGDEALQYVENIRRYYDSLVWLDEQGKI
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: SEPF_MYCBP
Sequence: MSTLHKVKAYFGMAPMEDYDDEYYDDRAPSRGYARPRFDDDYGRYDGRDYDDARSDSRGDLRGEPADYPPPGYRGGYADEPRFRPREFDRAEMTRPRFGSWLRNSTRGALAMDPRRMAMMFEDGHPLSKITTLRPKDYSEARTIGERFRDGSPVIMDLVSMDNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSPEERRRIAETGFYAYQ
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: LNT_BRUME
Sequence: MIARLAGRIILLNGWRRALAAFLSGAFATLTQPPFDIFVAGFVSFPVLVWLIDGAIARTDAGPLRRLLLAAKVGWWFGFGYFVSGLWWIGTALLVDADQFAWALPLAVLGLPAFLALFYAFAAMIARLLWSDGLGRILAFAFGFALAEWLRTFIFTGFPWNLIGYAAMPVPLLMQSVAVIGLVGMSALAVFVFAAPALLTGGHFARTGIGLAIFLALAHVGFGAWTLSRAPAIVDENGPLAVRIVQPSIAQAMKWDNAERRAIFDKLVGLTEEAPAEGKPRPDVIVWPETAIPYILESTPQALAHIGDALQEGQVLLAGAVREEKGADGGEPRYYNSIYTIDDRGRIVSTADKVHLVPFGEYLPFESFLRGLGLQEVVEMPGGFTAGTTRHALAVKDGRSFLPLICYEAIFPDELGYEGAGASAIINVTNDAWYGDTPGPYQHFRQAQVRAVEQGLPLIRAANNGLSAIVDTYGRITGSLALDAVGVVDSYLPSPRDPFWGRPPGWIQTVLILLTLLAASVGLILYSRRRFH
What is the function of this protein?
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
What are the official names of this protein?
Apolipoprotein N-acyltransferase, ALP N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LFTR_SYNJA
Sequence: MQVDIGAILTGYAQGYFLMADEETGSLAWYGTEQHALIPLDERFHCPRSLRPLVRGSCFQVRINGAFEQVVEGCAARPQTWISSELKQIYLALHQAGFAHSFETWQGDTLAGGILGIALGAAFIGESMFYRIPNASKVALVKLVEHLRERGFRLFDAQLMNPHLARFGAFLMDGRDYQELLQQCLRIPCRFD
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_TREPS
Sequence: MNDVRKILLRISYDGTRFCGWQKQVSGSRERAPSVQGELEKVAEKIHHQKIAVIGSGRTDSGVHAVGQAAHFCTPMRNILAYRFIPAFNSLLPHSIRITDAREVSSQLHARFSAVMRTYRYHLHCAPVAYAHELPYCWHIARMPDIHLLNQYAATLKGELDCTSFAAAGDKSASKSRYFYDTHFSFNHRVLTFEISANAFLWKMVRSLTGTLLHCEKKRCSVREFVRILHAKDRRLQGPPHRRMGYSYGTSVTPNTYSVQNRNTLARELASTGNARWKTY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: F227A_HUMAN
Sequence: MNHFRKMEVINLTTLPMIPVDEHLAVSLVARNTMVKTVRKELENNPPSCLIGSMHQVNQKIADINLRTEPSANSLAIERFELEKKALREKTRSSPEDKVKRQRKSQYSCKGSELRHARSSVIKRKTADKNLLAELYQYSNFNSSKPNKLPNGVDFCDMVGNVVRAERDCLSGKHFCSGRELEKFLSSSSPRAIWLDSFWWIFHERYQPNKELQNNLFDRIAQHYALLLFRVPKSHSEEALLKRLPSLLSKAVYTSFCCCFPQSWFDTHEFKSDICNTMSLWISGTYPSPQSYDSWDYSELDPERFRREELMLYRRRLTKGREFSLFAGKRAFSQKPAQSRKFYHPQSSSANSPSEKTSSAKQNSEKSLRMQNTAKEHHCQTLVLKKPTQEVKRISEARECENMFPKKSCAACKSPELTSNLFNIYGKSPLIVYFLQNYASLQQHGKNVLIVRREKTTSTPDCTPTYTDVISETLCSMKKRKDNLNQLYQHHWTEWNYFDKHLKELQDNFSREMKNIDPKAADTKKANHMFIPPSAVNEESPDKKTKEGKGGEGKRRETEVEHFFPLTSKP
What are the official names of this protein?
Protein FAM227A.
What is the protein family that this protein belongs to?
Belongs to the FAM227 family.
Protein: TLR2_BOSTR
Sequence: MPRALWPAWVWAIIILSMEGASDKASSLSCDPTGVCDGRSRSLNSIPSGLTAGVKSLDLSNNEITYVGNRDLQRCVNLKTLRLGANEIHTVEEDSFFHLRNLEYLDLSYNRLSNLSSSWFRSLYVLKFLNLLGNLYKTLGETSLFSHLPDLRTLKVGNSNSFTEIHEKDFTGLTFLEELEISAQNLQIYVPKSLKSIQNISHLILHLKQPVLLVDILVDIVSSLDCLELRDTNLHTFHFSEASISEMSTSVKKLIFRNVQFTDESFVEVVKLFNYVSGIVEVEFDDCTHDGIGDFRALSLDRIRHLGNVETLTIRKLHIPQFFLFQDLSSIYPLTGKVKRVTIENSKVFLVPCLLSQHLKSLEYLDLSENLMSEETLKNSACKDAWPFLQTLVLRQNRLKSLEKTGELLLTLKNLNNLDISKNNFLSMPETCQWPGKMKQLNLSSTKIRSLTQCLPQTLEILDVSNNNLDSFSLILPQLKELYISRNKLKTLPDASFLPVLSVMGISKNIINTFSKEQLDSFQQLKTLEAGGNNFICSCDFLSFTQGQQALGRVLVDWPDDYRCDSPSHVRGQRLQDARLSLSECHRAAVVSAACCALFLFLLLTGVLCHRFHGLWYMKIMWAWLQAKRKPRKAPRRDICYDAFVSYSERDSYWVENLMVQELEHFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCKYELDFSHFRLFDENNDAVILILLEPIDKKAIPQRFCKLRKIMNTKTYLEWPLDETQQEGFWLNLRAAIRS
What is the function of this protein?
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components.  Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  May also promote apoptosis in response to lipoproteins.  Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.  Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
What are the official names of this protein?
Toll-like receptor 2.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.
Protein: MKAR_CHAGB
Sequence: MAFNFDAQEILDRALDLWNSIPQAGQWALAGLGALYVAQPVLSFIQLFLNCFILSGTNLRKYGKKGTWAVVTGASDGLGKEFASQLAAKGFNLVLVSRTQSKLDTLARHLELRWSGLQTKTLAMDYSQDNDADYERLAELISGLDIGILVNNVGRSHSIPVPFLETAREELQDIITINCLGTLKTTQVVAPILAKRKKGLILTMGSFAGVMPTPYLATYSGSKAFLQHWSSSLASELKPHGVDVQLVVSYLVTTAMSKIRRTSLLIPNPKQFVSSALSKVGLTGNEMFPNTYTPWWSHAAFKWVIESTVGATSGVTIWFNRKMHVDIRTRALRKAEREAKKQ
What is the function of this protein?
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate.  Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation.  VLCFAs serve as precursors for ceramide and sphingolipids.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase, 3-ketoacyl-CoA reductase, 3-ketoreductase, KAR, Microsomal beta-keto-reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: LEUD_MYCVP
Sequence: MEAFRTHTGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRNDPSFVLNLAPFDKGSVLVAGPDFGTGSSREHAVWALMDFGFRVVISSRFADIFRGNAGKAGLLAAEVSQDDVELLWKLIEQHPGTEITVNLQDRTITAGTMMVLFNIDDYTAWRLLEGLDDIGLTLRKLDEIEDYERHRPEWKPHTLPA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: HMR1_RAT
Sequence: MMFLLPFLTVFLAKQSHTRTHSLRYFRLAISDPGPGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQRTFQTELRHLQRHYNHSGLHTYQRMIGCELLEDGSTTGFLQYAYDGQDFIVFDKDTLSWLAMDNVAHITKRAWEANLHELQYQKNWLEEECIAWLKRFLEYGSDALERTEHPVVRTTRKETFPGITTLFCRAHGFYPPEISMIWKKNGEEIVQEVDYGGVLPSGDGTYQMWVSVDLDPQTKDIYSCHVEHCGLQMVLEAPQESGNTLLVANTISGTIILIIVLAGVGALIWRRRSREPKEVMYQPTQVNEGSSPS
What is the function of this protein?
Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells.  In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity).  Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis.  Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity).  May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin.  Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity).  During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity).  Acts as an immune sensor of cancer cell metabolome.  May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity).
What are the official names of this protein?
Major histocompatibility complex class I-related gene protein, MHC class I-related gene protein.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=In the absence of antigen remains within the endoplasmic reticulum where it acts as a metabolite sensor. Antigen binding triggers trafficking of the ternary complex to the plasma membrane. After presentation, most of these complexes are rapidly internalized and degraded via endocytosis. A small subset recycles via endosomes back to the plasma membrane and may thus acquire and present new antigens that do not efficiently reach the endoplasmic reticulum.
Protein: YOSA_BACSU
Sequence: MGFYSGYSGGYSGGGYGSSFVLIVVLFILLIIVGATFLY
What are the official names of this protein?
SPbeta prophage-derived membrane protein YosA.
What is the protein family that this protein belongs to?
Belongs to the SscA family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.