PharMolix/UniProtQA huggingface dataset:
Protein: RNH2_SINFN
Sequence: MSRRKSPDSPLFQLEPVLPDFSFEITAKRDGFWPVAGADEAGRGPLAGPVVAAAVILDPDAVPGGLNDSKLLTAEQREALFTEIMATATVSIASSSAAHIDATDILKASLDAMRRAIDGLSIAARFALIDGRDVPQGLPCHAKAIVKGDSRSVSIAAASIVAKVTRDRMMARADATFPAYGFALHAGYATVRHRSAIDSHGPCSLHRMSFRPFREAQEQPLAVSTGPIDPN
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_YERPE
Sequence: MILIEHILGNVKKDPVWREKLKDATFDLLILDQREAQKSRCRKSSTQGLDLGISLDRNVVLADGDVLAWDEETNVAVVVQINLRDVMVIDLSELKSRSPDELIKTCFELGHALGNQHWKAVTKHNEVYVPLTVATTMMDSVMRTHGFQHLPFRFVKGAEILPLLTNSEARLLFGGAEDTDTHVHVASPLDEPHGSGLHIHGIHSHEEGHSHGDHDHDHSHSHGDHDHDHKH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_STRPD
Sequence: MISSFHRPTVARVNLQAIKENVASVQKHIPLGVKTYAVVKADAYGHGAVQVSKALLPQVDGYCVSNLDEALQLRQAGIDKEILILGVLLPNELELAVANAITVTIASLDWIALARLEKKECQGLKVHVKVDSGMGRIGLRSSKEVNLLIDSLKELGADVEGIFTHFATADEADDTKFNQQLQFFKKLIAGLEDKPRLVHASNSATSIWHSDTIFNAVRLGIVSYGLNPSGSNLSLPFPLQEALSLESSLVHVKMISAGDTVGYGATYTAKKSEYVGTVPIGYADGWTRNMQGFSVLVDGQFCEIIGRVSMDQLTIRLSKAYPLGTKVTLIGSNQQKNISTTDIANYRNTINYEVLCLLSDRIPRIY
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: G6PD_DROYA
Sequence: DHTALDLIIKSLKSPTMVCEGTHFDGKIPHTFVIFGASGDLAKKKIYPKLWWFYRDDLLPKLTKFCGYARSMLTVDSIKEQCLPYMKVQSHEQKKYEEFWALNEYVSGRYDGRTGFELLNQQLELMENKNKANRIFYLALPPSVFEEVTVNIKQICMSVCGWNRVIIEKPFGRDDASSQALSDHLAALFHEDQLYRIDHYLGKEMVQNLMTIRFGNKILSSTWNRENIASVLITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLVAMEKPVSCHPDDIRDEKVKVLKSIETLTLKDMVLGQYLGNPQGTTDDARTGYVEDPTVSDDSNTPTYALGVLKINNERWQGVPFILRCGKRLNERKAEVRIQYQDVPGDIFEGNTKRNELVIRVQPGEALYFKMMTKSPGITFDIEETELDLTYEHRYKDSYLPDAYERLILDVFCGSQMHFVRSDQLREAWRIFTPILHQIEREHIRPITYQYGSRGPKEADRMCEENNFKYSGSYKWHGGKAATSNL
What is the function of this protein?
Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TCTP_ORYSJ
Sequence: MLVYQDLLTGDELLSDSFPYREIENGILWEVDGKWVVQGAIDVDIGANPSAEGGGDDEGVDDQAVKVVDIVDTFRLQEQPPFDKKQFVTFMKRYIKNLSAKLDAEKQEEFKKNIEGATKYLLGKLKDLQFFVGESMHDDGGLVFAYYKDGATDPTFLYFSHGLKEVKC
What is the function of this protein?
Involved in calcium binding and microtubule stabilization.
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTA_SHIF8
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRAPDGKTHELSS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS8_CAUSK
Sequence: MSMNDPLSDMIARIKNAATRKRAKVATPASKLRARVLDVLADEGYIRGYSLVEKPGAFPEFEIELKYFDGEPVIAEIARVSKPGRRVYSSIKDLKPIKNGLGISILSTPKGVMSDSAARDANVGGEVLCRVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: FOLD_SHEDO
Sequence: MTAQLIDGKAIAQTIRSTLKQKVAARIEAGKRAPGLAVILVGLDAASKIYVGSKRRACEEVGFESRSFDLDINTSEADLLALIDKCNQDPSIDGILVQLPLPEHIDDSKVIERIRPDKDVDGFHPYNVGRLAQRIPVLRPCTPLGIMTLIKSTGVDTYGLDATIVGASNIVGRPMTLELLLAGCTTTTCHRFTKNLEQKVRQADLLVVAVGKPGFILGEWIKPGAIVIDVGINRLENGSLVGDVEFDAASQHAGFITPVPGGVGPMTIACLLENTLYAAETYHDVN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ENO_STRMK
Sequence: MSTIRSIHAREILDSRGNPTLEAEVILEDGSFGRAAVPSGASTGTKEAVELRDGDKTRYLGKGVRKAVDNVNTTIAAALKGFEATDQAGLDRRLIDLDGTENKGRLGANALLGVSMAAAHAAAASNKQALWQYLAARTGVTPSLPVPMMNIINGGAHADNNVDFQEFMVLPVGFTSFSEALRAGTEIFHSLKSVLKGHGLSTAVGDEGGFAPDFRSNVEALDTILEAIGKAGYTAGEDVLLGLDVASSEFFENGKYNLVGENKRLTSEQFVDFLADWAAQYPIITIEDGLAENDWAGWKLLTDRIGKKVQLVGDDLFVTNPKIFQEGIDSGTANAILIKVNQIGTLSETLEAIAMADRAGYAAVVSHRSGETEDTTIADIAVATTATQIKTGSLCRSDRVAKYNQLLRIEEALGAGARYAGRDAFVSLKR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: CCS1_TRICV
Sequence: MKQSVLRFLADLRFAISILLIIASCSVIGTVIEQDQSIEIYKLNYPLTNRIFGFLSWDIILKFGLDHVYKTWWFLGFIALFGLSLFTCTILQQFPSLKIARRCQFFRTTQQFGLLKLSRNLGNLSLSQLLFRIKKNQYSIFQQKNIVYCYKGLIGRIAPIIVHFSMILILIGAIFGALNGFKAQELIPKTEAFHVQNILSNGQLTRIPKVVSRVNDFWITYTKQATVAQFYSDVSILNTEGNEIVRKTIFVNSPIKYNNIDFYQTDWNVIGLRVQNDTSSILQYPLINLTNAGNKVWVTWIPSDSEFKKGLTILVDNLQGYCSIYDESGIFVGNLELNETFNLNMPITLVDILSSTGLQIKTDPGILLIYTGFLFLMLSTLISYITYSQIWIIQTNRQIFVGGNTTRATFDFEIEFLKLIK
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein Ccs1, ORF382.
What is the protein family that this protein belongs to?
Belongs to the Ccs1/CcsB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RIBD_BUCBP
Sequence: MKDIFYMKKAIKLAKKGSLTTSPNPNVGCIIVNNNIIVGSGWHKKTGMKHAEIYALKTSGEKAKGATAYITLEPCSHFGKTPPCCVALTKYGISRVVIATLDPNPKVSGNGVKWLKKHGILVTIGTLSKESIKINKGFFQRMTTGIPWIKLKLASSIDGRTALNNGKSKWITSDKARHDVQHVREKSDAIISSSETILFDNPLLTVRNTNNNDNNQKLLKHSKTFLKQPIRVIIDSKNRITPSHKCIKQPGLLFLIRIHSDNNIWPSHIKQIILNNKSKKIDLIDLVKMLAKYQINNILIEAGPSLSSSFLKLNIINELIIYIAPKILGNYAKPLFFLENYSNLSDVPQFKFEKITQIGKDLKLILTKHNSS
What is the function of this protein?
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibD.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the HTP reductase family.
Protein: TRPA_SHEB9
Sequence: MSDTSTNTGRYQATFAKLKTEGRGAFVPFVTLGDPSPVLSLKIIDTLVQNGADALELGFPFSDPLADGPVIQGANLRSLAAGTTPTACFELLAQVRAKYPELPIGLLLYANLVFANGIDAFYAKAQQAGVDSVLIADVPVEESAPFSEAAKAHGIAPIFIAPPNADSETLALVSASGEGYTYLLSRAGVTGTDTKAGVPVEEILSKLKTFNAPPPLLGFGIAEPAQVTAAIKAGAAGAISGSAVVKIIETHQHDEAKLLAALGDFTRAMKAAT
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RNPH_FRAT1
Sequence: MRPSGRNNDQLRNLKVTHNFTKHAEGSVLIEFGDTKVICTASVVAGVPKFKKDSGEGWLTAEYGMLPRSTHTRMDREAARGKQSGRTQEIQRLIGRALRASVDLTAIGENTIKVDCDVIQADGGTRTASITGASLAIADAIEYMKQNGMLDEQANPLLSQVAAISVGIYNNEPVLDLDYDEDSNAETDMNVVMNSNGGIIEIQGTAEGKDFSEEEFAKMLGLAKKGIKEIFATVF
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: LACG_STRP1
Sequence: MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYTAEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECHKRHVEPFVTLHHFDTPEALHSDGDFLNRENIEHFVNYAEFCFKEFSEVNYWTTFNEIGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDSGYSGEIGVVHALPTKYPFDANNPDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDLREEDFAALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDVPKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDGGRIDYVKKHLEVISDAISDGANVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWYKKVAETQVIE
What are the official names of this protein?
6-phospho-beta-galactosidase, Beta-D-phosphogalactoside galactohydrolase, PGALase, P-beta-Gal, PBG.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: YIDD_STRP2
Sequence: MKRILIALVRFYQRFISPVFPPSCRFELTCSNYMIQAIEKHGFKGVLMGLARILRCHPWSKTGKDPVPDHFSLKRNQEGE
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CP91_CONGL
Sequence: MHLSLARSAVLMLLLLFALGNFVVVQSGLITRDVDNGQLTDNRRNLQTEWNPLSLFMSRRSCNNSCQSHSDCASHCICTFRGCGAVNG
What is the function of this protein?
Neurotoxin.  In vivo, elicits 'spasmodic' symptomatology.
What are the official names of this protein?
Conotoxin Gm9.1, Conotoxin Gm9a, Spasmodic peptide.
What is the protein family that this protein belongs to?
Belongs to the conotoxin P superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMI_STRP3
Sequence: MQVQKSFKDKKTSGTLYLVPTPIGNLQDMTFRAVATLKEVDFICAEDTRNTGLLLKHFDIATKQISFHEHNAYEKIPDLIDLLISGRSLAQVSDAGMPSISDPGHDLVKAAIDSDITVVALPGASAGITALIASGLAPQPHVFYGFLPRKAGQQKAFFEDKHHYPETQMFYESPYRIKDTLTNMLACYGDRQVVLVRELTKLFEEYQRGSISEILSYLEETSLKGECLLIVAGAQVDSEVELTADVDLVSLVQKEIQAGAKPNQAIKTIAKAYQVNRQELYQQFHDL
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_BLOFL
Sequence: MRTSDFKFQLPKKLISRYPNLKRSECRLLVFDRLTTKITHHFFSDLPEILNPGDLLIFNDTRVIPARLYGYSVTGKKVEILIERILNDYQAVAHIYSSELVQLGEKFILGSNLNIYIYVIKIYYSYKLFKIYFDNINYNNVLSLLNDIGHIPIPPYFHRLDEIIDYELYQTVYGSKLGSIAAPTAGLHFDTLLINRLLNLGIEISFITLHIGSATFQPVRVTLIEHHVMHDEYIEVSQSTIESILRCKERKNRVIAVGTTVVKALETAAMNTKSLSIIESFSGYSRIFIFPGYRFKIVDSLITNFHLPESTLIMLVAAFAGYRNILRVYNAAIDLNYKFLSYGDSMFITCRSE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3773_ACIAC
Sequence: MALKTLPIEARPRERLLARGPSSLSDTELLAILLRTGIVGKGVMQMAQELLSPALPDPATGALRGGFGGIGGLLQADADALKRIKGLGPAKRTSLVAVLELARRMLAQTLPKRDLFHSPRAVRDYLQLHLGGKPHEVFSVLFLDSQNGLIAMEEMFRGTLSQASVYPREVVVRALHHHAAAVVLVHNHPSGQVQPSRADETLTRSLTDALRLVDVRVLDHIIVAPGSSLSMAEEGLI
What are the official names of this protein?
UPF0758 protein Aave_3773.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: SYR_LEGPL
Sequence: MRSMKAIIEYLLKQALINLQQSGEMPIDLEIEIKVENAKDPAHGDYATNLALVLAKPCRQAPKVLAERLVAVIPADPSVEKIEIAGAGFINFFMRSTARSLIISEILNKGKEFGQGNLGQSQKVLIEFVSANPTGPLHVGHGRGAAFGATLGNVLKAAGYDVTLEYYVNDAGRQMNILAVSVWLRYLELAGEPIAFPANGYKGQYVYEIAQEMWSEQGNQFVHPWISVVDNLPADEPEGGDKETYIDAIIARAQSLLGKDGFANFHQHALKTVLDDIKDDLQAFGVRFDSWFSEQSLFEDGSIGKGIQALKDRGHTYEREGALWFRATDFGDEKDRVLVRANGQTTYFASDVAYHWNKYDRGFDRVIDIFGADHHGYVTRIKTAVKALGHDESALDVILVQFAILYRGGDRVQMSTRSGSFVTLRELREEVGNDAARYFYVARKPEQHMDFDLDLAKSESSDNPVYYIQYAHARICSVLRQLKERGLKWDKDMGLKNLDLLEQQHEATLISLIARYPEVIQSAAASCEPHQLAYYLRELANGLHSYYNAIQLLCEQEQLRCARLCLLESVRQVLNNGLAILGVSAPESM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTDA_AERPE
Sequence: MRLAVAYSTGDPAGRGAGRALARLLSAEPTSCPGAVECFKAGYLTIAGFPVEAVRLEMLDEAPDPQASAVIVLSKHRAESGRKSLTVHHPGNPTEDNSLGGRPMELAVAYPALAKALLISLAKASRETGLAESYEVTLEATHHGPTTPSKPVVFAELGSTEEDWRNPLGWETLALAVEEAIKTLPQIERECIPAAGFGGTHYVPKHTRLQLESGYCIGHTIPRYAFDRGVTAEVLKNAILKSYPGPARVALVEKKSLKSPQRRMVEEASEEAGAKVEYI
What is the function of this protein?
D-aminoacyl-tRNA deacylase with broad substrate specificity.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, D-tyrosyl-tRNA(Tyr) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DtdA deacylase family.
Protein: CUA3A_TENMO
Sequence: GLIGAPIAAPLGYAAPFARAAVAAPVAVAKTVVADEYDPHPQYSYGYDIQDGLTGDSKNQQETRDGDVVQGSYSLVDPDGTRRTVEYTADPINGFNAVVHREPLVAKAVVAAPAIAKVHAPLAYGAPVAKYAFH
What is the function of this protein?
Component of the cuticle of the larva of Tenebrio molitor.
What are the official names of this protein?
Larval cuticle protein A3A, TM-LCP A3A, TM-A3A.
Protein: IRS1_RAT
Sequence: MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRTKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPNGHYILSRGGNGHRYIPGATMGTSPALTGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVVSIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDSSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSCSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSVTHPHHHALQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCLPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRVGPAPPGAASICRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKVSLPRTTGAAPPPSSTASASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAANTVSFGAGAAGGGSGGGSEDVKRHSSASFENVWLRPGDLGGASKESAPGCGAAGGLEKSLNYIDLDLVKDVKQHPQDCPSQQQSLPPPPPHQPLGSNEGSSPRRSSEDLSTYASINFQKQPEDRQ
What is the function of this protein?
May mediate the control of various cellular processes by insulin.  When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2.  Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.
What are the official names of this protein?
Insulin receptor substrate 1, IRS-1, pp185.
Protein: GRPE_PHOPR
Sequence: MNNEDKKLQDEQLQKETVEAAETVSAEEEFVEITAEEMQIARIAELEAALLSSDAKVKEAQDNVLRARAEGENVRRRSEVEIDKARKFALNKFTEELLPVIDNLERAIETADKNDEALKSMIEGVELTLKTMTATVEKFGLKQHNPVGEVFNPEFHQAMSIQESADHEPNTVMLVMQKGYELNGRIIRPAMVMVSKAAAGSVDMQA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JANB_DROSI
Sequence: MKMFKSLSLIPRIVSPFQKCYSTDLINLVGVPRVKITKGQNRYLLVNIHTHGFTKYGRVIVRGADVDNHLAIFDSILEELEPEGICAKILGGGRILNEPDNKKIKIYGTSRTFGGADHTRTRNILQAWTTYKDFKITVKQ
What is the function of this protein?
JanA and janB regulate somatic sex differentiation.
What are the official names of this protein?
Sex-regulated protein janus-B.
What is the protein family that this protein belongs to?
Belongs to the janus family.
Protein: HIS7_CAMJ8
Sequence: MSQKILFIDRDGTLIEEPKSDFQIDTLEKLRFEKDAIPTLLKLKNFGFKFIMVSNQDGLGTPSFPKENFEIAHEKMLDILKSCGIEFQDIFICPHFENENCACRKPKTAMLEEYIKHELYDKEQSFVIGDRESDMILASNLGVRGLRYGELSWKEIENEILSSFRSASYQRTTKETDIKVKVCLNGGKVSIKTGIDFFDHMLEQIAVHGGIGLEISCKGDLEIDEHHSVEDVALALGACIKKALGDKIGIARYGFALPMDECLASCAMDFCNRPHLVYKAKFKKSHLGALSTEMIEHFFYSLSYAMGVSLHLKVKGKNDHHKAEGLFKAFAKALKMAVKIESENLASSKGVI
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM135_HUMAN
Sequence: MAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDPRYTTVTPELPTEFS
What is the function of this protein?
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission.  May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L.  May be involved in peroxisome organization.
What are the official names of this protein?
Transmembrane protein 135, Peroxisomal membrane protein 52, PMP52.
What is the protein family that this protein belongs to?
Belongs to the TMEM135 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
Protein: TRPR_HAEIE
Sequence: MYISRNLEQWNAFLQMLKIAFEENKAQEFLTLLLTADERDAVGLRLQIVSQLIDKNMPQREIQQNLNTSAATITRGSNMIKTMDPDFMQWMKQHLDLIEKN
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription.
What are the official names of this protein?
Trp operon repressor homolog.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_TRYBB
Sequence: MSKKQEVKYYGSSAGKDQLVYGVVHIYASFNDTFVHVTDMSGRETFCKVTGGMKVKADRDESSPYAAMMAAQDVVARCKECGINALHVKMRATGGVGTKSPGPGAQAALRALARAGMKIGRIEDVTPVPTDSTRRKGSRRGRRL
What are the official names of this protein?
40S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: GLCM1_RAT
Sequence: MKFFTVLLFASLAATSLAAVPGSKDELHLRTQPTDAIPASQFTPSSHISKESTSSKDLSKESFIFNEELVSEDNVGTESTKPQSQEAQDGLRSGSSQQEETTSAATSEGKLTMLSQAVQKELGKVIEGFISGVEDIISGASGTVRP
What is the function of this protein?
Adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L-selectin.
What are the official names of this protein?
Glycosylation-dependent cell adhesion molecule 1, GlyCAM-1, Endothelial ligand FOR L-selectin, SGP50, Sulfated 50 kDa glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the PP3/GlyCAM-1 family.
What are the subcellular locations of this protein?
Cell membrane.