PharMolix/UniProtQA huggingface dataset:
Protein: OMPF_ECOL5
Sequence: MMKRNILAVIVPALLVAGTANAAEIYNKDGNKVDLYGKAVGLHYFSKGNGENSYGGNGDMTYARLGFKGETQINSDLTGYGQWEYNFQGNNSEGADAQTGNKTRLAFAGLKYADVGSFDYGRNYGVVYDALGYTDMLPEFGGDTAYSDDFFVGRVGGVATYRNSNFFGLVDGLNFAVQYLGKNERDTARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEESSLGKGKKAEQWATGLKYDANNIYLAANYGETRNATPITNKFTNTSGFANKTQDVLLVAQYQFDFGLRPSIAYTKSKAKDVEGIGDVDLVNYFEVGATYYFNKNMSTYVDYIINQIDSDNKLGVGSDDTVAVGIVYQF
What is the function of this protein?
(Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536.
What are the official names of this protein?
Outer membrane porin F, Outer membrane protein F, Porin OmpF.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: GPDA2_ARATH
Sequence: MAASVQPACLDLHFSGKHPPLLKHNAIIVRCVSSPNVIPEADSISGPPDIINTNRDQRKVVRIAWEKLVRWSRSLRAKAKTDVLERTRKVVVLGGGSFGTAMAAHVARRKEGLEVNMLVRDSFVCQSINENHHNCKYFPEHKLPENVIATTDAKAALLDADYCLHAVPVQFSSSFLEGIADYVDPGLPFISLSKGLELNTLRMMSQIIPIALKNPRQPFVALSGPSFALELMNNLPTAMVVASKDKKLANAVQQLLASSYLRINTSSDVTGVEIAGALKNVLAIAAGIVDGMNLGNNSMAALVSQGCSEIRWLATKMGAKPTTITGLSGTGDIMLTCFVNLSRNRTVGVRLGSGETLDDILTSMNQVAEGVATAGAVIALAQKYNVKLPVLTAVAKIIDNELTPTKAVLELMNLPQIEEV
What is the function of this protein?
Required to supply glycerol-3-phosphate in the chloroplast for the synthesis of glycerolipids.  Required for activation of systemic acquired resistance (SAR).  Provision of glycerol-3-phosphate may be involved in generating lipid signals necessary for mediating defense responses and SAR.
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, chloroplastic, Protein SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY 1.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL14_ESCF3
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RP54_CUPNH
Sequence: MKPSLQLRLSQHLALTPQLQQSIRLLQLSTLELQQEVEQALTENPLLERENDWIESPLRVAADGSVNLQSAPAPAPAEPQGNGEARADGAADDDSYGDSGNGDDYGSSDWSLDDFARRPQGDEDEKTPMQLREAEPTLREYLMEQLTPLKISARDKGLAIFLIESLDDDGYLSASLEEICTELPEELEFEIEEVHAILTLLQSFDPPGVGARNAAECLALQLRRLTHPQRELALNIVTNHLELLAVRDYTRLKKALQVDEAALKSAHELIRSLAPYPGHAYSRPEADFVVPDVFVRKGGGGWIAQLNPDVMPRLRINDMYAQILRGAKGESGTAGLQQKLQEARWLIKNIQQRFDKILRVSQAIVERQKNFFSHGEIAMRPLVLREIADTLGLHESTISRVTTNKYMATPMGTFELKYFFGSHVSTETGGAASSTAIRALIKQLIGAEDPRNPLSDSRIAELLGEQGFVVARRTVAKYREALKIPAVNLRKSL
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
RNA polymerase sigma-54 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: PSBT_ALLTE
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPKVPTKK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RRF_UREPA
Sequence: MNFKIYETKIREEFELVLKWMHNEFIKLRTGRATPAILDGILVNYYGSMMPINQLANISVPEPRVLAIKPYDRSSIKDIATAINASNLGVNPQVDVDIIRLTFAAPTEEVRKNLVKKAKQVGEEAKIRVRHIRQEAQDLFKKDSTTIEDDKKFFQTELDNLTKELNKEIETVVSHKEKDIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIRC1_AGRFC
Sequence: MKLLTFCSFKGGAGKTTALMGLCAAFASDGKRLALFDADENRPLTRWKENALRSNTWGSFCEVYAAEEMALLEAAYEDAELQGFDYALADTHGGSSELNNTIIASSNLLLIPTMLTPLDIDEALSTYRYVIELLLSENLAIPTAVLRQRVPVGRLTTSQRAMSDMLASLPVVQSPMHERDAFAAMKERGMLHLTLLNMRTDPTMRLLERNLRIAMEELVTISKLVSEALEG
What are the official names of this protein?
Protein virC1.
Protein: TX13C_HUMAN
Sequence: MAMNFGDHASGFRHDDVIRFINNEVLRNGGSPAFYTAFRSRPWNEVEDRLRAIVADPRVPRAIKRACTWSALALSVQVAARQQEELLYQVWWLQGHVEECQATSWALTSQLQQLRLEHEEVATQLHLTQAALQQVLNERDGLCGRLLEVERSMQVYPMPQDFVPGPEAGQYGPVAGTLNAEQSEAVATEAQGMPHSEAQVAAPTAVYYMPEPQSGRVQGMQPLLLMQAPHPVPFHMPSPMGLPYSTPLPPPVVMESAAAIAPQMPPAGIYPPGLWATVGSQEETAPPWDQKCHGQDGYPENFQGVYHPGDNRSCNQKEGSECPQGMTSQGDSSSHSLKKDPVMQEGTAPPEFSRSHSLEKKPVMPKEMVPLGDSNSHSLKKDPVVPKEIVPIGDSNSHSLTKNPVVHKEMVSLGDSNSHSMKKDPVMPQKMVPLGDSNSHSLKKDPMMCQEMVPLGDSNSHSLKKDPVVAQGTAPLMYSRRHSQKKVPMMPKEMVPLGESHSHSLKKDLVVPKELVPLGDSKSHRMKKDPVMPQKMVPLGDSRSHSLKKDPVMPQNMIPLEDSNSHSLKKDPVMPQNMIPLEDSNSHSLKKDPMMHQEMVPLGDSNSHSLKKDPVVPQDTAPLMFSRRHSLKKVPVMPKEMVPLGDSHSLKKDPVMPQNMVPLEDSNSHSLKKDPVVPQGTAPLMFSRRHSLKKVPVMPKEMVPLGDSNSHSLKKDPVVPQGTAPLMFSRRHSLKKVPVMPKEMVPLGDSHSLKKDPVMPQNMVPLEDSNSHSLKKDPVVPQGTAPLTFSRRHSLKKVPVVPQGTASLGFSRIHSLKKELVMPEEMVPLGDSNSHSMKKDLVMPKEMVPLGDSNSHSLKKDPVVHQEVVSLGDSNSHSLKKHPVIPQGTASLRFSKSHSQKEDQERPQVTPLEDSKSHGVKNSPWKHQPQGQKVKEQKRKKASESQQQKPASCSSPVNWACPWCNAMNFPRNKVCSKCKRVRMPVENGSVDPA
What are the official names of this protein?
Putative testis-expressed protein 13C.
What is the protein family that this protein belongs to?
Belongs to the TEX13 family.
Protein: COF_ECO24
Sequence: MARLAAFDMDGTLLMPDHHLGEKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: ASTE_ECO8A
Sequence: MDNFLALTLTGKKPVITEREINGVRWRWLGDGVLELTPLTPPQGALVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRGSLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQEPGGTFTHFSARHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMASDTLNFMPFEKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: ABDH_SHIFL
Sequence: MQHKLLINGERVSGEGEKQPVYNPATGDVLLEIAEVSAEQVDAAVRAADAAFAEWGQTTPKARAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: PPK31_SCHPO
Sequence: MTNPEQLKRILSHEVLLKIEMSKNGIVEYANPAFFELIGYEGDLFQCSFYEYLQSDDEHLMKKATDNLFRKSISVAHVFAFLRCNPIRSPNYYIQQAKAPFEGKTYIRMLFRGILVDSLYGKDTRVLWAGKYLYPQRSVINEMDFILFNTLGIGAFILHDHLLGIIKYNYIHVPPPSGKLCSLCEDNLPEWYFEVHSDFCLVWNDLVRRVFAVQQLINCKKLEIEDIVNKLPTGSNHMVEETFLSLPVITVFNGKKNRKQRFRIRSWRSSLNFLVKELDKSIKNFAYLEHRTFLTISNSAAKDMKREIYEKSLVNWEYDFLVPSKIQDYFYDVHSLLLKNLSSKIKLCNHILMYQATFNEVKNFLQTYSLNMLSIEMENIEGSLYFGNAQLSNLICVNQYLSEQRPVFFNRLLALGNVENNNSIYDDIQKRTERISTIKRHKKYFEIGERLTEKDLIVSKTFKTTRIDYFKAVKGSIEDLDVRPLKNRQKFVNKFYASIVHFLTESMQFPSHNDRRFGDNTPHSLDEFILLKEINRGAYGRVYLAKKRSSGKYFALKMIPKSSLDSLKKIKGLLLEKRNMHIQRYGPNTVKLYYAFDSGDYLCLVMDYFNGGDCETLIQKLGPLPEQWVCQYAAELLNAIELLHQDGIIHHDIKPANMLVDETGHIRLTDFGLSENVEEKKEVYKLTKRMSFEQKHGNLYEQLQPKKFEFVRYVRNYRGNIDELEKAESPQQNSDYANDSVQHLLDFDINNMDETAIHMLMNQLEKKENRTFIKKDISGTPNYMAPEILMGVDTQMGDIWAMGCVIFEMLTGTRPFEANTVKAIWARIERNDIGWTKRVKESCSKEAVDLITKLMDPDCNKRLGSNGYQEIKKHPFFRTIKWDNLNSGPGPFVPQTENVEDLTYFEKNISGSDNINKNNCQTSATLILNGIFAFHPPPKATPADSGTETSNSAAFSASEEETTNLTDQKRKDLFSLITKAFKGIDLKALNYNNKATLLRMYDEVDFPKNQQRNKEKFRIQKRPNKKYRYHLF
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Serine/threonine-protein kinase ppk31, Meiotically up-regulated gene 25 protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIG01_BOARA
Sequence: MAFLKKSLFLVLFLGLVSLSIGEEEKREEEEKNEEGANQEENAENKEKRFIGTLIPLALGALTKLFKG
What is the function of this protein?
Antimicrobial peptide that displays antibacterial and antiprotozoal activity (PubMed:32967114).  Exhibits antibacterial activity against the Gram-positive bacteria S. epidermidis ATCC 12228 (MIC=2 uM), E. casseliflavus ATCC 700327 (MIC=16 uM), S. aureus ATCC 25923 (MIC=4 uM) and E. faecalis ATCC 29212 (MIC=8 uM), and the Gram-negative bacteria E. coli ATCC 25922 (MIC=16 uM) and K. pneumoniae ATCC 13883 (MIC=4 uM) (PubMed:32967114).  Displays antiprotozoal activity against the epimastigote form of T. cruzi (IC(50)=15. 9 uM) (PubMed:32967114).  Does not show antimicrobial activity against the Gram-negative bacterium P. aeruginosa ATCC 27853, or the fungi C. albicans ATCC 90028 and C. parapsilosis ATCC 22019 (PubMed:32967114).  Shows high cytolytic activity against human erythrocytes (HC(50)=10 uM), and displays anti-proliferative effects against various cancer cell lines including MCF-7 breast cancer cells (IC(50)=13. 7 uM), HeLa cervical adenocarcinoma cells (IC(50)=11. 1 uM) and B16F10 murine melanoma cells (IC(50)=10. 5 uM) (PubMed:32967114).
What are the official names of this protein?
Figainin 1, Br24.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL11_PELTS
Sequence: MAKRVAAIVKLQVPAGKATPAPPVGPALGQHGVNIMAFVKEYNERTAAQAGLIIPVEITVYEDRSFTFVTKTPPAAVLLKKAAGLETASGEPNKKKVAKLPRSKVKEIAELKMPDLNAASIEAAMRMIEGTARSMGIDIVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CH601_SYNJB
Sequence: MAKSIIFSEEARRALEHGMDILAEAVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVSLIRQAASKTNDTAGDGTTTATVLAHAMVKEGLKNVAAGANPIALKRGIDKAVKFLVDKIAEHARPVEDSKAIAQVAAISAGNDEEVGRMIAEAMDKVGREGVISLEEGKSMTTELEVTEGMRFDKGYISPYFVTDTERMEAVLENPYILITDKKITLVQDLVPVLEQVARAGRPLLIIAEDIEKEALATLVVNKLRGVLSVVAVKAPGFGDRRKAMLEDIAILTGGEVISEERGLKLENARLDSFGTARRVTVTKDNTTIVAEGNEAAVKARCEQIRRQIEETDSTYDKEKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINATKAAVEEGIVPGGGTTLAHLIPVVTEWAQANLSGDELVGANLVARALGAPLRRIAENAGQNGSIVLERVKDKPFNTGYDAQNDAFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTEAIVVDKPEPKTNTPASSGSGMSDYDY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMI_PSET1
Sequence: MTSAVYLQAGRDKSLKRKHPWLFSKAIKKIKGKPGLGDTVTIHDSEGKFLATAAYSPHSQIRARVWSFDEKEVIDQHFFERRLRRALEARSQVIEEGGLTGFRLCAAESDFLPGVTIDKFDNVLVCQLLSAGAERHKGEIVGALMAIFPGMSIYERSDVEVRTKEGLEPIKGALWGNEPTAPVLIAENGFKIEVDIIDGHKTGFYLDQRDSRAALERFSKDKTVLNCFSYTGTFSLYALRGGCKHVTNVDVSQPALDTAKRNVEHNNLDLDKVDFVKQDVFKLLRQYREDGVLFDTIVMDPPKFADNKAQLTGACRGYKDINMIAMQILKPGGTLLTFSCSGLMEQNLFQKVVADAALDAGKDLLIMERLNQAADHPIAGSYPEGFYLKGLICKVY
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WFDC5_CHLAE
Sequence: MRIQSLLLLGALLAVGSQLPAVFGRKKGEKWGGCPADDGPCLLSVPDQCVEDSQCPLTRKCCYRACFRQCVPRVSVKPGSCPQDQLRCLSPVNHQCHKDSDCSGKKRCCHSACGRDCRDPARG
What is the function of this protein?
Putative acid-stable proteinase inhibitor.
What are the official names of this protein?
WAP four-disulfide core domain protein 5.
What are the subcellular locations of this protein?
Secreted.
Protein: DCOR_HAEIN
Sequence: MPNLKIAYSPKVEQYFSTNRELVEIAKTDFTDVAAIVLSSSDVGEYLDRIKATKFDVPVFIVQTDEQQVDPKFYDSIYHIQDLNGYDIKLYSRQIETAAKLYEEKMLPPFFKMLSEYVEMGNIAFDCPGHQGGQYYRKHPAGRFLYDFYGENIFRSDICNADVKLGDLLIHEGAACDAQKYAAQVFNADKTYFVLNGTSSSNKVALNAVLAPGDLVLFDRNNHKSNHHGALIQAGATPIYLETARNPFGFIGGIDSHCFEEDYLKSLIKEVAPEKLNQKRPFRLAVIQLGTYDGTIYNARQVVDKIGHLCDYILFDSAWVGYEQFIPMMKDCSPLLLELNENDPGILVTQSVHKQQAGFSQTSQIHKKDKHIKGQDRYVNHKRFNNAFMLHASTSPFYPLFATLDVNAKIQGSEAGRRLWHECVKVGIEARKLVLNHCELIRPFIPTTIKGKKWQDYDTEEIATNLEFFKFHPTDTWHKFEGYADEQYFVDPCKFLLTTPGISLETGEYEEFGVPATILANYLRENGIIPEKCDLNSILFLLTPAETITKMQTLVAQIALFEKHIKQDSLLKYVLPTVYKNNEDRYKGYTIRQLCQEMHDLYVSRNVKQLQKDLFRKATLPEYVLNPHDANIELIRNKVELVPLTDIVGRVAAEGALPYPPGVLCVVPGEKWSTTAHQYFLALEEGINTLPGFAPEIQGVYLQKDPDGRTRAYGYVLTDY
What are the official names of this protein?
Ornithine decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-I family.
Protein: TBL1X_MACFA
Sequence: MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQRAFREKLAQQQASAAAAAAAATTSASVSQQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVDIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
What is the function of this protein?
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units.  Plays an essential role in transcription activation mediated by nuclear receptors.  Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
What are the official names of this protein?
F-box-like/WD repeat-containing protein TBL1X.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EBI family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalized with MECP2 to the heterochromatin foci.
Protein: GLYA_HAEIE
Sequence: MFTRNMTIADYDPVLWQAIQDENRRQEEHIELIASENYASPRVMEAQGSQFTNKYAEGYPGKRYYGGCEYADIVEQLAIDRAKELFGADYVNVQPHSGSQANAAVYGALINAGDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITADGLIDYEDVRQKALECKPKLIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLGGPRGGLILSSCGDEEIYKKLQSSVFPANQGGPLVHIIAAKAVCFKEALEPQYKEYQANVIKNAKAMVEVFKQRGYDVVSNGTENHLFLVSFIKQGLTGKAADAALGKANITVNKNAVPNDPQKPFVTSGIRVGTPSVTRRGSNENDVRELAGWMCDVLDALGKENEEQVIAETKEKVLAICKRLPVYPK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHI1_MYCTO
Sequence: MSIFTKIINRELPGRFVYEDDDVVAFLTIEPMTQGHTLVVPRAEIDHWQNVDPALFGRVMSVSQLIGKAVCRAFSTQRAGMIIAGLEVPHLHIHVFPTRSLSDFGFANVDRNPSPGSLDEAQAKIRAALAQLA
What are the official names of this protein?
Uncharacterized HIT-like protein MT0784.
Protein: DAPKR_DROME
Sequence: MFTEKGIFPIGDGLLDVDADRLKGLLVSCPDINEIYEVEQTPFARGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWLKDDCSLDRQIYLQPQSDAEEEEEEDVDDDVEDEEEEEQVEEEEEETQNVEEPTTEAPQQQQQPVQQHQLAKSGQIHSKPTHNGHHRANSGGSISKIPIATSKLQSTPSSETTTAIHTLTSNSNGHVHKPTQIVTPTRRASDSDKENTYTATFVKKPVATIQLGSSNGIEDATVVATLTLFPDAPTTPKVIRKTPTGESNGSATSVKALVKKFQLEDSSGSAVARRSGGAVTSSSGLHSPTTTSVRLNSIRRASEPLTTVYKKQTSQNGCSSTSNPSSSPGSSPTTSGSTATLLIHSQRLGNSTAPASHCVAVPATATATSSASSSNSSSGKSTSAAHHLHHHHMHHHHHHHHHHVVIAAKNAAAVAATNNLSLDQGIIC
What are the official names of this protein?
Death-associated protein kinase related.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: DNJC3_HUMAN
Sequence: MVAPGSVTSRLGSVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNEEEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGGPFRFKFHFN
What is the function of this protein?
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress.  Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity).  Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity.  May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A.  May inhibit EIF2AK3/PERK activity.
What are the official names of this protein?
DnaJ homolog subfamily C member 3, Endoplasmic reticulum DNA J domain-containing protein 6, ER-resident protein ERdj6, ERdj6, Interferon-induced, double-stranded RNA-activated protein kinase inhibitor, Protein kinase inhibitor of 58 kDa, Protein kinase inhibitor p58.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: HEPPA_BORBR
Sequence: MSSARFESKILSRAELVAAVAAGRLPRPLVFTNGVFDILHRGHVTYLDQAAQLGATLVVAVNTDESVRRLGKGSDRPLNQVQDRAALLAALGCVDAVTSFHEDTPQELIGELRPDLIVKGGDYDMDTLPETALVKSWGGRAVAIPFDFERSTTALLGKIRQG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.  Cannot use GTP, UTP, or CTP as substrate.  Is not active against the alpha-anomer substrate.  Is also able to catalyze the ADP transfer to beta-glucose 1-phosphate in vitro, yielding ADP-beta-glucose.
What are the official names of this protein?
D-beta-D-heptose 1-phosphate adenylyltransferase, D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the cytidylyltransferase family.
Protein: GLXK_BACC1
Sequence: MKVVIASDSYKESLKAIEVCEAIERGFGAIFPKAEYVKIPIGDGGEGTVDSLVDATSGRIISFHVTGPLRESVQAFYGMSKDKKTAFIEMAAASGLQHVPAKKRNPLITTTKGTGELILHALDEGAEHIILGLGGSATNDGGAGMLSALGVRFINGKGEVIEPSGGTLHSIVSIDFSQMDSRLKHIKIEAACDVDNPLVGIRGASFVFGRQKGADEEMMKELDENLKHYAHILKQYLFCDVSKIPGAGAAGGMGAAVIAVLKGSLRRGIEIVLDYTNFDKHIEGADLIITGEGRIDEQTAYGKAPVGVAERAKLFHIPVIAIGGSVSPNYSAVHEKGIDAVFSITTSPTTLEEAYKVAEENIEMTAKNIAAVWKIASEKHF
What are the official names of this protein?
Glycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the glycerate kinase type-1 family.
Protein: IFA3_CAEEL
Sequence: MADPDSYRSSITSRPAFNRTVTSSTQNYGTPASGNRVLKIVTETHTSSVASGLSPYGQGAASTIRDDREREKKEITELNDRLASYIGKVRFLAAQNRKLEADLNVLQSRFGKSTGSVKIMYEMEITTATNVVKETGKDHEEAEKEIGKIKDQLDELRKKFEEAQKGRAEDRLKIDELLVTLSNLEAEINLLKRRIALLEEEVARLKKENFRLTSELQRVRSELDQETLLRIDNQNKVTTILEEIDFMKRGFETELKDLQAQAARDTTSENREYFKNELMNSIRDIRAEYDRFMAGNRNDLESWSQIRVQEINTQTNRQNAEINHKRDEVKRLHSQVSELKSKHAELAARNGLLEKQLEDLNYQLEDDQRSYEAALNDKDAQVRKLREECQALLVELQMLLDTKQTLDGELKVYRRMLEGNSEENGLRQLVEKVVRTSAINEEVDTETMRVVKGEHSSRTSYQRSAKGNVSIKEVSPEGKFVILENTHRDKEEPLGDWKLKRKIDGKREIVFTFPSDYILHPVQTVKIFARGNGVANPPEVLVFEGDDTFGAGANVQTILYNNSGEERATHMQRQSQQTTTS
What is the function of this protein?
Cytoplasmic intermediate filaments provide mechanical strength to cells.  Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle.  Required for epidermal morphogenesis in embryos.  Probable component of embryonic epidermal attachment structures.
What are the official names of this protein?
Intermediate filament protein ifa-3, Cel IF A3, Intermediate filament protein A3, IF-A3.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_THEON
Sequence: MRERLFSLISKYGLRANSDLGQNFLIVDDIIERNVERAELSGRDVVLEIGPGLGVLTDALSKRAGKVYAIEKDPRLVEILRKEYNWSNVEIIEGDALKVDFPEFNKIVSNLPYQISSPITFRFLGYGFERAVLIYQLEFAQRMVARPGDRNYSRLSLMVQAKSYVELVERIGRGAFYPRPKVDSAVIVLEPKPKSEVIELNEDLVRALFQHRRSTVAAALKKSHHMLGLSKAEFKNVKDVISSAPYAEKRVFQLSPEEVKEIEAYLKVNNII
What is the function of this protein?
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Probable ribosomal RNA small subunit methyltransferase A, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.