PharMolix/UniProtQA huggingface dataset:
Protein: GID8_YEAST
Sequence: MTISTLSNETTKSGSCSGQGKNGGKDFTYGKKCFTKEEWKEQVAKYSAMGELYANKTIHYPLKIQPNSSGGSQDEGFATIQTTPIEPTLPRLLLNYFVSMAYEDSSIRMAKELGFIRNNKDIAVFNDLYKIKERFHIKHLIKLGRINEAMEEINSIFGLEVLEETFNATGSYTGRTDRQQQQQQQQFDIDGDLHFKLLLLNLIEMIRSHHQQENITKDSNDFILNLIQYSQNKLAIKASSSVKKMQELELAMTLLLFPLSDSADSGSIKLPKSLQNLYSISLRSKIADLVNEKLLKFIHPRIQFEISNNNSKFPDLLNSDKKIITQNFTVYNNNLVNGSNGTKITHISSDQPINEKMSSNEVTAAANSVWLNQRDGNVGTGSAATTFHNLENKNYWNQTSELLSSSNGKEKGLEFNNYYSSEFPYEPRLTQIMKLWCWCENQLHHNQIGVPRVEN
What is the function of this protein?
Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616).  Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616).  Required also for cell cycle progression.  Positively controls G1 and the timing of START (PubMed:15590836).
What are the official names of this protein?
Glucose-induced degradation protein 8, Dosage-dependent cell cycle regulator 1.
What is the protein family that this protein belongs to?
Belongs to the GID8 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: HRCA_FRACC
Sequence: MLEDRRLEVLRAIVEDFVLSNEPVGSKALAERHNLGVSPATVRNDMSALEEEGYITQPHTSAGRIPTDKGYRLFVDRLSGVKPLSRAERRAIQSFLEGAVDLDDVVRRSVRLLAQLTRQVAVVQYPSLSSSSIRHIEVVTLGPYRLLMVLITDTGRVEQRIVDSLVPVDDEVAGELRSVLNCALAGRRLVDAPDIVAALPDSTRSELRPYLTTVAGAVLESLVERQEERIAMAGTANLTRSPVDFADSLRSILEALEEQVVLMKLIGSARETGTVTVRIGRETDVDALRSTAVVATGYGRGPFALGGMGVLGPMRMDYPGTMAAVRAVAKYVGELLGAD
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: METN_SHIBS
Sequence: MIKLSNITKVFHQGTRIIQALNNVSLHVPAGQIYGVIGASGAGKSTLIRCVNLLERPTEGSVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVFGNVALPLELDNTPKDEIKRRVTELLSLVGLGDKHDSYPSNLSGGQKQRVAIARALASNPKVLLCDEATSALDPATTRSILELLKDINRRLGLTILLITHEMDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RPIA_ACIB5
Sequence: MSLYATQDEKKQAAAKAALKHLPKGGILGVGTGSTVNFLIDLLPELQLEAAVASSQATADRLKKLGIEVVDMNHVGSLDAYVDGADEIDRHMHMIKGGGAALTREKIVASIAKKFVCIVDDSKWVDQLGRDFPLPVEVIPMARSAVARKLVSLGGDPVYREGVVTDNGNVILDVFNLNILNAIDLEKTINNIPGVVTNGIFALNPATIAIVATNDGIEERTAQ
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: PAN2_ASPCL
Sequence: MEADWDELSRIPVPAPSSHGLPTIATTIAFDDVSELLWAGNEFGRITSFYGPELQRYTSVRAHPVSDGPVRQILFHERGVISLSPKSVHMITRRGLSQWHIAHEEMTDLHCMSFTAQLNRIIVAGCQSAMFTIDIDKGVIVDKLQTDHNYTMMKKSRYLCAATDTGSVNALSLSDFQVVKSWKAHGTAINDMDARNDLLVTCGFSVRHLGSPIVDPLANVYDLKTLSPLPPIPFHAGAAYVRMHPKLHTTSFVASQTGQLQVVDLMNPNAINLRQANVSFMLGIDISPSGEALAINDAECAIHLWGSPSKVHFNEMSKEVEFADVVPRPPSLDWSPDTPLNMIGMPYYHERLFSAWPSHLVFEVGNPPASIDQSLIPYLRPAEMGHYAPNPKKTRRYQVENTRALTTAESALIAPKFLSEKAREQTRAKSEGSVSDTAEALAGAKLNGEAEDDPLLKYSNVEIKYSRFGVDDFDFRFYNQTIFSGLETHIANSFTNALLQLLKFIPLVRNLALHHAASTCIYETCLLCEMGYLFDMLEKANGQNCQATNLLKAFSSYREASNLGLLEENLTTKSLSSAIQSVNRFFLNQIAHDFRMILPSSDDLDHRLATIASESIRCMFCQNEIVRPGNSLANELIYPAIDIKQARRNPAFKFSNILRASIERETQNRGWCNYCRRYQQVTIRKTVHRMPLVLILNAALNNPLCRRLWSIPGWLPEEIGIVVEGGQVMCYEGDELKAQVQNKVPNLVLYDLVGLVAEIDIPEHQKAHLVSFINVSISSRETESKSRWHLFNDFLVTEVDKDEALRFNQPWKIPCVLAYQARDARHGVDDAWKDTLDTTLLFRDWSLNGGRPVESRQTLTEEEKPTPGTPVALDTEFVDLEKAEIDVKADGSQEIVRPNKSGLARVSVLRGSGIHEGVPFIDDYITIKEPIVDYVTQYSGIKPGDLDPRTSQHNLVPLKVAYKKLWLLLNLGCIFVGHGLASDFRKINIQVPKNQTVDTQYLYFHPGKNRRLSLRYLAWAVFKEYIQEESTDANQGHDSVEDARMALRLWKKFQEYEDAGIVNQILEEIFREGSRLGFRPPPRNGVATVLSRPGTAVTMQNNSGRNTPSTPDVGGAAAAAATTSAPATPRQAFRRSIALTPSNGTFGGPGTGDFFGGSPLK
What is the function of this protein?
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex catalytic subunit pan2, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. PAN2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_CITBB
Sequence: MLTKRIIPCLDVKGGRVVKGVQFLGLRDAGDPVEIAELYDQQGADELTFLDITASSDDRDIIIDVVRRTAERVFMPLTVGGGVRVVEDIRRLLNAGADKVSINTAAVHRPEFVSEAAEKFGSQCTVVAIDARSRAGGGWEVYTHGGRNPTGIDAVEWAQRMEGMGAGEILLTSMDRDGTKDGYDLPLTRAVVDAVSIPVIASGGVGGLSHLYDGFTQAGASACLAASIFHYREYTIEEAKSYLRERGVPVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRKH_ECOLI
Sequence: MHFRAITRIVGLLVILFSGTMIIPGLVALIYRDGAGRAFTQTFFVALAIGSMLWWPNRKEKGELKSREGFLIVVLFWTVLGSVGALPFIFSESPNLTITDAFFESFSGLTTTGATTLVGLDSLPHAILFYRQMLQWFGGMGIIVLAVAILPILGVGGMQLYRAEMPGPLKDNKMRPRIAETAKTLWLIYVLLTVACALALWFAGMDAFDAIGHSFATIAIGGFSTHDASIGYFDSPTINTIIAIFLLISGCNYGLHFSLLSGRSLKVYWRDPEFRMFIGVQFTLVVICTLVLWFHNVYSSALMTINQAFFQVVSMATTAGFTTDSIARWPLFLPVLLLCSAFIGGCAGSTGGGLKVIRILLLFKQGNRELKRLVHPNAVYSIKLGNRALPERILEAVWGFFSAYALVFIVSMLAIIATGVDDFSAFASVVATLNNLGPGLGVVADNFTSMNPVAKWILIANMLFGRLEVFTLLVLFTPTFWRE
What is the function of this protein?
Low-affinity potassium transport system.  Interacts with Trk system potassium uptake protein TrkA.  Requires TrkE (sapD) for transport activity, 20% more uptake is seen with both SapD and SapF (PubMed:11700350).  Transport in the absence of SapD and SapF is dependent on a high membrane potential and a high cytoplasmic ATP concentration, suggesting this protein may be able to interact with other ATP-binding proteins (PubMed:11700350).  Can transport potassium and rubidium (PubMed:7896723).
What are the official names of this protein?
Trk system potassium uptake protein TrkH.
What is the protein family that this protein belongs to?
Belongs to the TrkH potassium transport family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS18_STRPZ
Sequence: MAQQRRGGFKRRKKVDFIAANKIEYVDYKDTELLSRFVSERGKILPRRVPGTSAKNQRKVTTAIKRARVMALMPYVNED
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RL11_DICT6
Sequence: MPKKVVGKVKLQLPAGKATPAPPVGPALGQYGVNIMEFCKAYNAATAGQEGMIIPVEITIYEDRSFTFVTKTPPASDLLKKAAGVEKGSGEPNKVKVGKVKRSKIREIAELKMKDLNANDIEAAMRMIEGTARSMGIEIIEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: H4Y_BLEJA
Sequence: MGGKGGKGGKGLGKVGAKKRHSRRVIRENIQGITKPAIRRLARRGGVK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NACA_DICDI
Sequence: MADSDVKKVTKGEKKTREAMKKLGLAPVSDIFRVTIKQKEGVLVVVAEPEVYASPSGETYVVFGDHSFDDIASRLQKAVPKANVDDIVKAAMPAPTAVKESEESEEIVAQAVDSFDYKGVNPKDVEVVMKETKASREKVVETLIATKNDLVSAVLELTTN
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  May also be involved in transcription regulation (By similarity).
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GP5_PRRSS
Sequence: MKCSHKLGHSLTPHSCFWWLFLLCTGLSWSFADGNGNNSTYQYIYNLTICELNGTNWLSGHFEWAVETFVLYPVVTHILSLGFLTTSHFFDALGLGAVSTAGFVGGRYVLSSVYGACAFAAFVCFVIRAAKNCMACRYARTRFTNFIVDDRGGVHRWKSPIVVEKLGKAEIGGNLVTIKHVVLEGVKAQPLTRTSAEQWEA
What is the function of this protein?
Major envelope protein present in abundant amounts in the virion envelope.  Mediates virion sialic acid-dependent attachment the sialoadhesin receptor SIGLEC1.  This attachment induces virion internalization into alveolar macrophages predominantly through clathrin-dependent endocytosis.
What are the official names of this protein?
Glycoprotein 5, Protein GP5, G(L).
What is the protein family that this protein belongs to?
Belongs to the arteriviridae GP5 protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein.
Protein: GNPI2_XENTR
Sequence: MRLVILDDYALASEWAAKYICNRIIQFSPGPDKYFTLGLPTGSTPLGCYKKLIEYHKSGDLSFKYVKTFNMDEYVGLPRDHPESYHSYMWNNFFKHIDIDPSNAHILDGNASDLQAECEDFERKIKEAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNRLVDPLHSMKKN
What are the official names of this protein?
Glucosamine-6-phosphate isomerase 2, Glucosamine-6-phosphate deaminase 2, GNPDA 2, GlcN6P deaminase 2.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y301_ENCCU
Sequence: MAAPTQLPETAKPKHSNQSEAGPAPLASPTAPMPRPASHLAPMPSDHPDFRSKSARLRCQPPRTNNCGTFKQPPSVAATSRPKPGNPFLQPPTKGTPPPKKKKKNHTEGCHTHEANPEPNTKHTETEPPIISHCPPPHPGPTATPNLLPCPNPTSSFCQNTRDSPSLPPQRPNMVHIPETPLQRRHSPSQIPIRIPPSPYNLSTAKTYYYLQPPYLPILSHEIHFIVPLLCPYEHHTHNRAARREPATLENNPRHRSIRLNYIPSHHVPHLRRRQF
What are the official names of this protein?
UPF0328 protein ECU03_0010.
What is the protein family that this protein belongs to?
Belongs to the UPF0328 family.
Protein: RPOA_THEPX
Sequence: MFEMIEPKIEIIEQSEDGTYGKFVVEPLERGYGITLGNSLRRVLLSSLPGAAPKSVKIDGVLHEFSTLPGVKEDVVEIILNLKEVAVKLHSDEPVVGRIDVEGRGEVTAGHIKGSADIEILNPDHHIATLSDDGKLHMEIVFVKGKGYVPSDKNKEPNQPIGVIPVDSIFTPVKRVSYNVENTRVGHVTDYDKLTLEVWTNGAVTPKEAISMASDMLIKYFQKFISFTGEYKSSDIFVDKPEKKVEKPLDMTIEELDLSVRSYNCLKRAGINTVQELTQKTEEEMMKVRNLGKKSLEEVKQKLEALGLSLKKADE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: COPB2_PONAB
Sequence: MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAVQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAERDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHAELWPAKQYPLVTPNEERNVMEEAKGFQPSRSTAQQELDGKPASPTPVIVASHTANKEEKSLLELEVDLDNLELVDIDTTDINLDEDILDD
What is the function of this protein?
This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type.  It binds to Golgi membranes in a GTP-dependent manner (By similarity).
What are the official names of this protein?
Coatomer subunit beta', Beta'-coat protein, Beta'-COP.
What is the protein family that this protein belongs to?
Belongs to the WD repeat COPB2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi.
Protein: PMGE_RABIT
Sequence: MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREKMALNHGEEQVRIWRRSYNVTPPPIEESHPYYHEIYSDRRYRVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRGKTVLISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKRAEK
What is the function of this protein?
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG).  Also exhibits mutase (EC 5. 4. 2. 11) activity.
What are the official names of this protein?
Bisphosphoglycerate mutase, BPGM, 2,3-bisphosphoglycerate mutase, erythrocyte, 2,3-bisphosphoglycerate synthase, BPG-dependent PGAM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: CDK1_ORYLA
Sequence: MEDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDVLMQESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCHRRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVWPDVESLPDYKNTFPKWKEGSLSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLDKSTLPAACINGV
What is the function of this protein?
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins.  Required in higher cells for entry into S-phase and mitosis.  May play a role in regulating the amplitude of the cyclic expression of circadian clock genes.
What are the official names of this protein?
Cyclin-dependent kinase 1, CDK1, Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: DXR_CHLAB
Sequence: MKHLAIFGSTGSVGQQALAIIRSLPHLFNVVALASYGNKRDLFFEQIREFSPSIVSVYDEQLYFEIRKEFPKVQAFLCEEGLLAAATANEIDTIVAASSGIVALPAIIAAMRSGKTLALANKEVLVSAGELINGLAQQYQTKILPIDSEHNALYQCLEGRDTSEVRKLFLTASGGPLLYKSKEELTRVTIQDVLKHPIWNMGAKITVDSSTLVNKGLEIIEAYWLFGLEHAEIDAVIHPQSLIHGMVEFEDGTVLSVMNPPSMLFPIQHVLTTPKRCPAPHKGMDFSIKQILEFFPIDEERFPSIALARQVLQDKGSSGPFFNAANEILVQRFLKKEIAWCDILDKLTRLMKNHRVSSCTSLDDVFSVDKEARALAQEI
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: ISU2_YEAST
Sequence: MFARLANPAHFKPLTGSHITRAAKRLYHPKVIDHYTNPRNVGSMDKSLANVGTGIVGAPACGDVIKLQIQVNDKSGIIENVKFKTFGCGSAIASSSYMTELVRGMSLDEAVKIKNTEIAKELSLPPVKLHCSMLAEDAIKAAIKDYKTKRNPSVLH
What is the function of this protein?
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.  First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2.  In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins.  Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH.  Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1 (PubMed:23615440).  ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (By similarity).  ISU2 is the minor isoform in yeast and is not detectable in cells grown to stationary phase (PubMed:10588895).  Also involved in production of a sulfur precursor required for thiolation of cytoplasmic tRNAs (PubMed:31040179).
What are the official names of this protein?
Iron sulfur cluster assembly protein 2, mitochondrial, Iron sulfur cluster scaffold protein 2.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NUD17_XENLA
Sequence: MESAKRVLVYLTKENSLLQCAKFAQGITGHYSANNGDKAFIHCGLEKNQFVISDCQFLGSARVQLQRPSFCPIKNLSPRQSASLPQEIQGRGVDVGVAVLVQSINKKVLLTRRSKSLNIFPNVWVPPGGHVELGEQLLEAGLRELQEETGLRLQEVSWSMLGLWESAFPPLLSRGLPSRHHIVTYLLVQTNETHQQMQERLCPDEREVSACVWLDTEIAKHIVAAEDSGSPCGPLPASISVLELIHGSLSQSDRSMATFLNSAPKEGEDIERISTGTKYALSLWLDGMPTNSSPCA
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Nucleoside diphosphate-linked moiety X motif 17, Nudix motif 17.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: TRM1_SCHPO
Sequence: MYEANMLRLSQRISNAVNHFSTAMMSGASASLTEGSAIIPFSNPNEVFYNPVQQFNRDLSVTAIRAWSETRSKKIVAKSHHRHQLLDQNSELSQENLTKCDTTHDFEKNCSEKTDSTSADNIAGFTILEALSATGLRSIRYAKELPNVKRILANDLLENAVKTIEKNVNYNNVSDIVIPNKGDANAVMHMNKFHYDVIDLDPYGSAAPFLDAAVQSVSKDGLLCITCTDSAVLAGNAYPEKCFSNYGGSSLRSNFCHEQAVRHLLYAIAASAAKYGRAIKPLLSLSIDFYFRVFVQIKAKPVLVKNLQSQSLLIYHCSGCGSFAEQPLGKTSPGRLPGTTKFSNASGPPVSANCEHCGYVHHVGGPLWGGPLHDAEFLKKMRAIAEDLDPEVYGTKRRILGMLALADEELPDVPFYFVLSQICSVLRSQSPPQNIFVSALLNAGYRVSGSHAKSNAIKTNAPWSFVWDVLRSWIKDHPVKLENISKTSAGAAILEKTPTAEVDFTFRPDSEFASKKEGYTRYQMNPTENWGPKSKPGKRTIAEVDSKS
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear/cytoplasmic compartments.
Protein: KTHY_METS3
Sequence: MYIVFEGIDGAGKSTQINLLKDWLDQNGFDVETVVEPTDSEVGKLIRKILQRPDATTDRIQKTLGLLFAADRMLIMDKLNDDSKVILSDRSFISSLAYQEPAEWIEQINKYAKEPDLVLLLDVDVKTSVNRCSKEDEFENEEFLSKVKANYLDLISNFNHEIIDASTGVNKVSTDIKKAVAPYMGICPDCIR
What are the official names of this protein?
Probable thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: CYB_BASCU
Sequence: MALNLRKNHQILKIINDALIDLPAPSNISTWWNFGSLLGICLITQIVTGLLLAMHYTADTSLAFSSVAHMCRDVQFGWLIRNLHANGASFFFICIYLHIGRGLYYGSYLNKETWNVGVLLLLALMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFVIVGLTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYTIKDILGFVLMLSLLVSLALFAPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASILVLFLTPLLHTSKLRSMTFRPLSQILFWTLVANVLILTWVGSQPVEHPFIIIGQLASFTYFTIILILFPLAAALENKLLKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.