PharMolix/UniProtQA huggingface dataset:
Protein: EFG_ZYMMO
Sequence: MARKYPLDKYRNIGIMAHIDAGKTTTTERILFYTGKSYKIGEVHEGTATMDWMEQEQERGITITSAATTCFWNDHRINIIDTPGHVDFTIEVERSLRVLDGAVACFDGVAGVEPQSETVWRQAEKYHVPRMCFVNKLDRTGANFMRCVDMIRDRLGARPLVLYLPIGIESDFKGLVDLVENRAIIWLEESLGAKFEYQEIPEEYKAEAEAARAEMIEMAVEQDDAAMEAYLEGNEPDADTLKKLIRKGTLAQDFVPVLCGSAFKNKGVQPLLDAVVDFLPSPLDIPPVEGVKMDGETKDSRKPSDDEPFSALAFKIMNDPFVGSLTFARIYSGKLTKGTVLNSVKDKREKVGRMLLMHANSREDLEEAYAGDIVALVGMKETTTGDTLCAPNAPIILERMEFPEPVIEVAVEPKTKADQEKMGLALNRLAAEDPSFRVASDFESGQTIIKGMGELHLDILVDRMKREFKVEANVGAPQVAYRESLARPVEVDYTHKKQSGGSGQFGRVKVNLVPSERGAGIQFFDEIKGGNIPREYIPSVEKGMRETAETGSLIGFPIIDFEIHLTDGAYHDVDSSALAFEIAGRGAMREAAQKAGIKLLEPVMRVEVITPEDYLGDVIGDMNSRRGQIQGTDTRGNAQVVEAMVPLANMFGYVNQLRSFTQGRAQYSMQFSHYDEVPANVADELKSKMA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_METLZ
Sequence: MAEETGALPSRTDFSAWYNEVIRRADIMDVRYPVKGLYVWYPFGFALRNHTYTLLRSLLNRDHEETLFPLLIPETEFMKEAEHIKGFEDEVYWVTHGGLSPLDVKLALRPTSETAIYPMYALWVRSHADLPLKLYQVVNTFRYETKHTRPLIRLREITSFMESHTVHTDWDDANKQVEYELGLATEFYRDLGVPIIISRRPDWDKFPGADFTMAIDAVMPDGRTLQIGTVHHLGDHFSTTYNITYEDVNGEQKLASQTCFGISERCIAAIIAVHGDDKGLVLPATVAPTQVVIIPIIVGKRGDEIMAAVEKLESELKAAGLRVKTDARDMRPGAKYYHWELHGVPLRVELGPRDLDNNQLVCANRLGVKTTIPRENAADSVKRLLDEAHDQILEKAEDHLSSHLKTVKTVDECNQSLEENIVIVHWCGEKACADKLEELTNSSLLGTGVRSKYVVDDEGPCIVCGKPGKTALVGRSY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBX2_YEAST
Sequence: MPVVNHEDSEFHLSHTEEDKLNEFQVITNFPPEDLPDVVRLLRNHGWQLEPALSRYFDGEWKGEPDQMGEPTQTSTPMAETLVPPALGPRPLLFTASLPVVRPLPANFRNDFRTIGLNGRSNTVWSMFESFSYDGNPFLFILLLIPRIINRLSATIFTFFCTLLSLHSISGGGNSGKPKISKVPKAPTRETHIPLAEILGDTKDKDAFCELKSFKPDISFNEALRIAKEEFKFMLLILVGDTYDTDTDTVDVNSKLLLEKILLNKKTLQYLRKIDNDLIIYLKCVHELEPWLVARQLGVRNTPEIFLIANVANKASHSETLPSQRLSILGKLKVNSLNRFLQSLTNVVEKYTPELVVNKTEMHELRMSREIKKLQEDAYKKSLEMDRIKAIEKEKSLKHAQDLKLNSTARQLKWLKACIDEIQPFETTGKQATLQFRTSSGKRFVKKFPSMTTLYQIYQSIGCHIYLAVYSSDPAEWSNALQDKIRQLSADDDMLCFKEGQLETATATTIEELGHIINNELTSFDLERGKLEFDFELVSPFPKYTVHPNEHMSVDQVPQLWPNGSLLVEALDEEDEEDEENEEQ
What is the function of this protein?
Integral endoplasmic reticulum membrane protein that coordinates the assembly of the ER-associated protein degradation (ERAD) machinery at the ER membrane.  Mediates binding of CDC48 to the E3 ubiquitin ligases SSM4/DOA10 and HRD1, and to ERAD substrates.  Component of the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.  ERAD-C substrates are ubiquitinated through DOA10 in conjunction with the E2 ubiquitin-conjugating enzymes UBC6 and UBC7-CUE1.  Also a component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).  ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1.  Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome.
What are the official names of this protein?
UBX domain-containing protein 2, Secretion lowering protein 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: BPIA3_HUMAN
Sequence: MMCPLWRLLIFLGLLALPLAPHKQPWPGLAQAHRDNKSTLARIIAQGLIKHNAESRIQNIHFGDRLNASAQVAPGLVGWLISGRKHQQQQESSINITNIQLDCGGIQISFHKEWFSANISLEFDLELRPSFDNNIVKMCAHMSIVVEFWLEKDEFGRRDLVIGKCDAEPSSVHVAILTEAIPPKMNQFLYNLKENLQKVLPHMVESQVCPLIGEILGQLDVKLLKSLIEQEAAHEPTHHETSQPSACQAGESPS
What are the official names of this protein?
BPI fold-containing family A member 3, Short palate, lung and nasal epithelium carcinoma-associated protein 3.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZINT_ECOLI
Sequence: MAIRLYKLAVALGVFIVSAPAFSHGHHSHGKPLTEVEQKAANGVFDDANVQNRTLSDWDGVWQSVYPLLQSGKLDPVFQKKADADKTKTFAEIKDYYHKGYATDIEMIGIEDGIVEFHRNNETTSCKYDYDGYKILTYKSGKKGVRYLFECKDPESKAPKYIQFSDHIIAPRKSSHFHIFMGNDSQQSLLNEMENWPTYYPYQLSSEEVVEEMMSH
What is the function of this protein?
May function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions.  Binds zinc with high affinity, and can also bind cadmium, mercury or nickel.  Preferentially binds Zn(2+) over Cd(2+).  Contains one high affinity metal binding site, and can bind additional metal ions at other sites.
What are the official names of this protein?
Metal-binding protein ZinT, Cadmium-induced protein ZinT.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. ZinT family.
What are the subcellular locations of this protein?
Cytoplasm. Periplasm. Note=Cytoplasmic in nonstressed cells, and exported to the periplasm upon exposure to cadmium.
Protein: CAPZB_RAT
Sequence: MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.  Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).  Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit beta, CapZ beta.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere.
Protein: QUEC_LEGPC
Sequence: MKKAVVLLSGGLDSTTCLALAKSQGFACYALSFSYGQRHSAELCAATRIAKHMDAADHKIVTLDTALFGGSALTDASIEVPEFKESPEIPVTYVPARNTIFLAMALGYAESIGARDIFIGASSVDYSHYPDCRPEFIESFQSLANLATKAGIEGDRFTINAPLQYLSKVQTIQLGTELGVDYGLTVSCYQANEAGEACGQCDSCTFRKRGFKSAGVNDPTRYQKCVHI
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: AGRB_STAAB
Sequence: MNYFDNKIDQFATYLQKRNNLDHIQFLQVRLGMQIIVGNFLKILVTYSISIFLSVFLYTLVTHLSYMLIRYNAHGAHAKSSILCYIQSILIFVFVPYFLINIDINFTYLLALSIIGLISVVIYAPAATKKQPIPIKLVKRKKYVSIIMYLLVMILSLIIHPFYAQFMLLGILVESITLLPIFFPKED
What is the function of this protein?
Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP).  This quorum sensing system is responsible for the regulation of the expression of virulence factor genes.  Involved in the proteolytic processing of AgrD, the precursor of AIP.
What are the official names of this protein?
Accessory gene regulator protein B.
What is the protein family that this protein belongs to?
Belongs to the AgrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRM44_DEBHA
Sequence: MVKHTKSKNDFDAELLLSETSKIGDPWVPIYQTAVDIEAHHFETAMSNLIKQPNINSTVIMRADILKENVFDVENGDSTFVSKLINKVPEFPSENPDDVILHRYLDDIDLRTISLNNSELKLNTKCEVVRRIIPRNPFKDHIINQTCLVLSSSNADPESHTEKESDDSVLVVYIPHIQSSDEIPFYLPPVYGVGILYHKSTLSIQYLPFNYQNYKTSPEIQLSLRNLDVTERPIRIALRLLQTSSKHSLGAKSGYEKRVNHDLVVPKIAFQNRYITLKKKYSSNLVNSWCESTDPKKHVFEDLAIAAFLIELWTVKYKSREDFEFRDLGCGNGLLVYILNMEGYSGKGIDARSRKSWSTYPENVQNNLSEQIIIPSVLLKPHPALSRLIPNVTDNFRYFQAPQLPSKNNCSCEAENVPADDKSTSHTNSSSTLTTYSSANLLESSQVCTTEEFPPNTFIIGNHSDELTCWIPLLGYPFMVIPCCSHALSGAKVRYSPRKQQKSNQQQNVSTYGALVDHTEDLAKQMGWIVEKEMLRIPSTRNAAIIATKRQPHCIDENDEVTQTRVLDILALEGGAEGWVENSINLMKKAPRNH
What is the function of this protein?
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
What are the official names of this protein?
tRNA (uracil-O(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TRM44 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_RHOPB
Sequence: MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVTGPVEDGMSTLTVAQLLFLEAENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGHPDMRFSLPNSRIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNEIYVKHTGQTYKAIEDALERDKFLTADMARDFGIVDKVIDKRSEEPTPKAP
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_THIDA
Sequence: MARTTPIERYRNIGISAHIDAGKTTTTERILFYTGKSHKIGEVHDGAATMDWMEQEQERGITITSAATTCFWKGMDGKFPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYGVPRLAFVNKMDRSGADFFKVYEQMRARLKANPVPIQVPIGAEDKFEGVVDLVKMKAIYWDDASQGMKFDLRDIPANLVDTCKKWREAMLEAAAESSEELMNKYLEEGDLPEADIIAALRARTIASEIVPMMCGTAFKNKGVQAMLDKVIELMPAPTDIPPVKGELENGEAGERQATDEEKFSALAFKVATDPYVGQLIFFRVYSGVVNSGDTIYNPVKGRKERIGRILQMHANQREEIKEVRAGDIAAAVGLKDVTTGDTLCDLNAPITLERMEFPEPVIHVAVEPKTKADQEKMGIALGRLAQEDPSFRVRTDEESGQTIISGMGELHLEILVDRMKREFGVEANVGAPQVAYREAIRKEVEQEGKHAKQSGGKGQYGHVWIKMGPNEAGKGFEFIDAIKGGTVPREFIPAVEKGLREALNNGVLAGFPVVDVKVTLFDGSYHDVDSSELAFKLAAILAFKDGMRKASPVLLEPMMAVEVETPEDYMGDVMGDLNRRRGIIQGMDDAAGIKLVKAEVPLAEMFGYSTDLRSMSQGRATYSMEFKHYSEAPKSVAEAIIAKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VM2_BOTAT
Sequence: EAGEECDCGAPENPCCDAATCKLRPGAQCAEGLCCDQCRFKGAGKICRRARGDNPDDRCTGQSADCPRNRFY
What is the function of this protein?
Inhibits fibrinogen interaction with platelets.  Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.  Also inhibits T24 and SK-Mel-28 cell adhesion to fibronectin with IC(50) of 4. 4 uM and 33 nM, respectively.
What are the official names of this protein?
Disintegrin batroxostatin, Disintegrin colombistatin, Platelet aggregation activation inhibitor.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL10_EUPES
Sequence: MGRRPARCYRQIKNKPYPKSRFCRGVPDPKIRIYDVGMKKKGVDEFPFCVHLVSWEKENVSSEALEAARIACNKYMTKFAGKDAFHLRVRVHPFHVLRINKMLSCAGADRLQTGMRGAFGKPQGVCARVAIGQVLLSVRCKDNNSHNAQEALRRAKFKFPGRQKIIVSRKWGFTKINRADYPRLKSENRILPDGVNAKLLGCHGRLANRKPGRAFIDAVA
What are the official names of this protein?
60S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: F16PC_STAAC
Sequence: MTQITEKELKKKYLDLLSQNFDTPEKLATEIINLESILELPKGTEHFVSDLHGEYEAFQHVLRNGSGNVRAKINDIFKERLSTKELNDLTALVYYPEDKLKLIKSDFQNCGQLNVWYITTIEHLIELIKYCSSKYTRSKLRKALPKQYVYIIEELLYKSNEYQNKKSYYETLVNQVIELKQADDLIIGLAYSVQRLVVDHLHVVGDIYDRGPQPDKIMDTLINYHSLDIQWGNHDVLWVGAYAGSKVCLANLLRICARYDNLDIIEDAYGINLRPLLTLAEKYYDADNPAFKPKKRPDKHERLTQREESQITKIHQAIAMIQFKLEIPIIKRRPNFEMEERLVLEKVNYDTNEITVYGNTYPLKDTCFQTVNRDNPAELLPEEEEVMNKLLLSFQQSEKLRRHMSFLMRKGSLYLPYNGNLLIHGCIPVDENGEMESFEIDGHTYSGQELLDVFEYHVRKSFDEKENTDDLSTDLVWYLWTGKYSSLFGKRAMTTFERYFIADKASHKEEKNPYYHLREDVNMVRKMLSDFGLNPDEGRIINGHTPVKEINGEDPIKADGKMLVIDGGFSKAYQSTTGIAGYTLLYNSFGMQLVAHQQFNAKEKILSEGIDELSIKRVVDKELQRKKIRDTNIGKDLQAQIDILKMLMHDRYLD
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 3, FBPase class 3, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 3 family.
Protein: FTSQ_RHIME
Sequence: MLALRGRRGKRVRYPADGVAEADEAFVLPRPLRRGVRFLISLGAGRIRFPNHTGTVAAAAFMVATGLYGMSLGGHTQSFAQVSTTAAGFAIEDVRVSGNAQTSEIDILQQLGLDGTTSLVALDIEEARRLIGELPWVETVTVRKVYPGTIEVVLKEREAFGIWQHGSDLSLIERSGSVIAPLRDNKFASLPLFVGRDAETAAAAFYDEFSRWPEFRSRVKAFVRVAGRRWDLRLNNGVVVKLPEKDVARAMSVLAGMQDTHQLLERDIAAVDLRLEDRTTVQLTPEAVKRREVALKAREKMLKAQEKRI
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: TORD_HAES1
Sequence: MITLNTEEKIFIYSWLKNILSHELTEQQLQQYQQGVFTPLFDFLSEQDLAEQINTVRNSLMQLSNLPLAHLELAADFAQLFLLNGENSALPYASAYLSEKELNQHIAFIDHLLLKYQLKFDHSLREPSDHLAVYLELLITLEKSGQKEKSFNFIQHYLLAWLIPFNKKVQKIKTETSFYQAITEILITLLNKT
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8E_SACS2
Sequence: MGFYQGPDNRKITGGLKGKHRDKRKYEIGNPPTFTTLSAEDIRIKDRTLGGNFKVRLKYTTTANVLDPATNTAKKVKILEILETPANKELARRGIIIRGAKIRTEAGLAVVTSRPGQDGVINAVLLKNESQRS
What are the official names of this protein?
30S ribosomal protein S8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: UPPP2_RHORT
Sequence: MDLVMLIKAAILGLVEGITEFLPISSTGHLIIAGSLLDFLDEQKRDVFVIVIQLGAILAVCWEYRRRLTDVVAGLGSDPQSWKFVTNLLIAFLPAVVLGLTFGKAIKAHLFSPVPVATAFIVGGLVILWAERRRHPIRVREVDEMTWVDALKIGLAQCFALIPGTSRSGATIIGGLFFGLSRKAATEFSFFLAIPTLTAASLYDLYKNRALLDGDMSGLMAVGFVVSFLSALVAVRGLIRYISRHDFTVFAWYRIAFGLVVLATAWSGLVSWSA
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MUTS_NITWN
Sequence: MMEQYLEIKAANPGLLLFYRMGDFYELFFEDAEIASRALGITLTKRGKHQGADIPMCGVPVERSDDYLHRLIAAGHRVAVCEQTEDPSAARKRGNKSVVRRDVVRLVTPGTLTEDTLLDARANNYLLALARARASSGVDRFALAWIDISTAEFMVTECGANELAATLARINPNEVIVSDTLHGDPDLGALLRELPSVTPLPRDTFDGATAERRLCDYFAVATMDGLSAMSRLEATAAAAAVTYIDRTQIGQRPPLSPPSREASGSTMAIDPATRANLELTRTLAGERRGSLLDAIDRTMTAAGSRLLAQRLAAPLTDTAAITRRLDAVAALTADGAARDDIRAILRTAPDMSRALARLSLGRGGPRDLAGLRDGVMAADQTLARLAGLSDPPEGIAAAMQALRGPSRELARELGNALSENLPLMKRDGGFVREGYDTALDEARKLRDDSRLVVAAMQARYAEETGVKTLKIRHNNVLGYFVEVTAQHANRLMSAPLNATFIHRQTLAGQVRFTTSELGEIEARIANAGERALGLELDIFDRLAAMAIRNGDEIRNAAHAFAQLDVAASFAKLAIDENYTRPDIDASLSFAIEGGRHPVVEQALKRTGQPFIANACDLSPPPPPVEGSGESGQIWLLTGPNMAGKSTFLRQNALIALMAQVGSFVPASRARIGIIDRLFSRVGAADDLARGRSTFMVEMVETAVILNQASERALVILDEIGRGTATFDGLSIAWATIEHLHESNRCRALFATHYHELTALSAKLPRLFNATVRVKEWHGEVVFLHEVLPGAADRSYGIQVARLAGLPPSVIARAKSVLAKLEAQDRGSTVRVLVDDLPLFAVTSRTGESAPTGETSPLIEALKSLHPDEMSPREALDALYALKAKLPKQ
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: UBC2_NEUCR
Sequence: MSTAARRRLMRDFKRMQTDPPAGVSASPVPDNVMTWNAVIIGPADTPFEDGTFRLVMHFEEQYPNKPPSVKFISEMFHPNVYATGELCLDILQNRWSPTYDVAAVLTSIQSLLNDPNTGSPANVEASNLYKDNRKEYHKRVRETVEKSWED
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.  Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 2, E2 ubiquitin-conjugating enzyme 2, Mutagen-sensitive protein 8, Ubiquitin carrier protein ubc2, Ubiquitin-protein ligase ubc2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PTH_SACD2
Sequence: MKTPDTCIQLIVGLGNPGNEYEHTRHNAGQDFVEELARDLGQPLSPTPKFFGHFSRLNINGKDVRLLVPTTYMNRSGQAVAAVCQFYKIPPEAVLVVHDELDLPPGKARLKIGGGHGGHNGLRDIISSLGNNKDFGRLRLGIGHPGNAKLVSNYVLKKAPSEEFNAIEDAIRAAQPHVADLAKGDWEKAMRELHSKT
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_RICTY
Sequence: MYRYKITIEYLGTHFSGWQRQAGVLSVQQILEEAIYKFSGEQVTLFGSGRTDAGVHAIGQIAHFDLSKYLEPYKIIKAINYFVRPYAVGVWNCELVSNNFHARFSATSRHYIYRIVNRTYPSVIDLNRVWWISAPLDVLAMQQAATYLLGKHDFTSFRSSSCQSKSPIKTLTEINIIKEYEEIKLYLSAPSFLHYMVRNIVGSLVLVGKNIWQVEQIKNVLDAKDRKVAGPTAPAFGLYFIKAEY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: CPTP_XENLA
Sequence: MSSTEEKFSLKEVLVSFKACLIDDDKDVILEHYVNGWKGLVRFMSSLGTIFSFVSKDAVSKIQIMESYLAGPNGERYRTLQSMVEYELSSDLVDLTKRSDHTDSGCRTLLRLHRALRWLQLFLEKLRVSNEDSKTSTLCTEAYNDSLANFHPWIVRKAATVSFIALPYRNTFFEIMNVGTTEEVVAMLGESMPYVTKVYDFTQEVYSQHNLLELP
What is the function of this protein?
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane.  Required for normal structure of the Golgi stacks.  Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0).  Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid.  Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide.  C1P transfer is stimulated by phosphatidylserine in C1P source vesicles.  Regulates autophagy and pyroptosis, but not apoptosis.
What are the official names of this protein?
Ceramide-1-phosphate transfer protein, Glycolipid transfer protein domain-containing protein 1, CPTP.
What is the protein family that this protein belongs to?
Belongs to the GLTP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Nucleus outer membrane; Peripheral membrane protein.
Protein: RSD_ECO57
Sequence: MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_GLOVI
Sequence: MSLGILGRKLGMTQIFDEEGRAIPVTVVEAGPCPVTQVKSEATDGYTAVQLGFGTAREKVLTRPEVGHCKKAGLEAPVRHLREFRLPDSSQYTPGQQITVDLFAAGQLVDVVGTSIGKGFAGGQKRHHFGRGPMAHGSKNHRAPGSIGAGTTPGRVFPGKRMPGRMGNERVTVRKLTVVRVIPERNVILIQGGLPGVEGGLLMISPAKSVGRAKG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.