PharMolix/UniProtQA huggingface dataset:
Protein: SYL_LEGPH
Sequence: MDNTYNPQEVEEQAQQYWHKKQSFNVTEDLNKEKFYCLSMFPYPSGTLHMGHVRNYTLGDVIARYQRALGKNVLQPIGWDAFGLPAENAAIKNKIPPAEWTRKNIAAMKEQFLRLGNAYDWKREITTCDPEYYRWEQWFFIRLFEKGLVYKKNAVVNWDPVDQTVLANEQVVDGRGWRSGALVERKEISQWFIKITSYADELLSSLDSLDEWPAQVKQMQRNWIGKSIGTEIYFNVNNYPKRLKIYTTRPDTLMGATYLAVATDHPLAKEAASNNKKVQEFLDSCQGIKIAEAELATMEKRGIDTGMTAIHPITGKELPIWVANFVLMQYGSGAVMAVPAHDQRDWEFAQKYQLPVKQVIKPIDIEHDFNQSAYTEEGILINSNQFDNLLSSKAIQVITNFLEENDAGKATINYRLRDWGVSRQRYWGTPIPMIICEQCGIVPVPDEELPVVLPENVDFTGTGSPLTQCKEFVNVTCPKCGQDATRETDTFDTFVESSWYYARFACKGQENAMLDDRAKYWTPVDQYIGGIEHAVMHLLYARFFHKLMRDEGLVNSDEPFKALLTQGMVLKDGHKMSKSLGNVVDPNHLINTYGADTARLFVMFASPPEQSLEWSDSGVEGAHRFLKRVWAFSHQHRDMLIDINDSILSGNGHVDWKEAESRLKKSRHIVHQILAQATHDYDRNQFNTVVSGCMKLFNEISDYSIETENDKFFIHSSISILLRLLAPITPHICHCLWQQLGFDKAIIDAPWPKVDKSALKTDEVDYVVQVNGKLRAQFTASTDATEEELIAAAKEHAHNFVVNHTIKKAIIVPHRQLINLVIG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHL_PROM1
Sequence: MSLISIVCLIPFGLIGAVNPIITLSAYAVLGGMYLFVVPLFLFYWMNNRWNVMGKFERLFIYGLVFLFFPGMVLFAPFLNLRMNGKEES
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit L, NAD(P)H dehydrogenase I subunit L, NDH-1 subunit L, NDH-L.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhL subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: GLGB_MARN8
Sequence: MESPALSEFDLHLFAEGRHWHIYNVLGAHLVNHRGTEGTRFAVWAPNARAVSVIGDFNNWDSGRHAMAVNNGYGVWSLFIPGVKAGHLYKFAITTRNGHHITKTDPYGQAFEHRPSNAAVVTERGHYAWGDGDWLERRNRFDWQQSPISVYEVHPGSWRHHGSGRWLTYRELADQLVPYVLETGFTHIELLPVTEHPLDESWGYQTTGYYAPTSRFGSPDDLRYFVDQCHQNNIGVILDWVPGHFPDDDFALAEFDGTALYEHEDPRRGRHQDWGTLIYNYGRHEVRNFLIGSALFWLDTFHMDGLRVDAVASMLYLNYSRNEGEWLPNEHGGHENLDAIRFLQDLNRVCQSRFPGVLMMAEESTSWPRVTRPPEIGGLGFNLKWNMGWMHDTLHYLQQDPVYRQYHHDKLTFGLLYAFSENFVLPLSHDEVVHGKSSLIQKMPGDDWQQRASLRLLFSYMFSYPGAKLLFMGGEFGQRQEWSERRELDWYLLQYPEHQGLRKLVQDLNGLYRRYPALHRKSFTSEGFEWIDCHDSTQSVISFLRNPGTPEHGPLVIVANFTPIPRHHYRIGVPTGGNWQEIFNSDSTWYGGSNLGNPLLLQAEPTPWMARPCSVELTVPPLGLVMLRPAT
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: ACYP_PSELT
Sequence: MQALFIKISGRVHGVGFRYFTYKLANKMKIKGYVRNAEDGSVEIHAEAPEEILVEFLKAVSIGPPMATVISVKYERVAGQNFTSFDIVP
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: UXT_MOUSE
Sequence: MATPPKRRALDTVGEKVLRYETFISDVLQRDLQKVLDHRDKVYEQLSVYLQLRNVIERLQETNHSELYMQVDLGCNFFVDTVVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSDSLTKDSMNIKAHIHMMLEGLRELQGLQNFPEPSPH
What is the function of this protein?
Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.
What are the official names of this protein?
Protein UXT, Ubiquitously expressed transcript protein.
What is the protein family that this protein belongs to?
Belongs to the UXT family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localizes to the nucleus. Localizes to spindle pole during mitosis.
Protein: AMPA_HAEIE
Sequence: MKYQAKNTALSQATDCIVLGIYENNKFSKSFNEIDQLTQGYLNDLVKSGELTGKLAQTILLRDLQGLSAKRLLIVGCGKKGELTERQYKQIIQAVLKTLKETNTREVISYLTEIELKDRDLYWNIRFAIETIEHTNYQFDHFKSQKAETSVLESFIFNTDCNQAQQAISHANAISSGIKAARDIANMPPNICNPAYLAEQAKNLAENSTALSLKVVDEEEMAKLGMNAYLAVSKGSENRAYMSVLTFNNAPDKNAKPIVLVGKGLTFDAGGISLKPAADMDEMKYDMCGAASVFGTMKAIAQLNLPLNVIGVLAGCENLPDGNAYRPGDILTTMNGLTVEVLNTDAEGRLVLCDALTYVERFEPELVIDVATLTGACVVALGQHNSGLVSTDNNLANALLQAATETTDKAWRLPLSEEYQEQLKSPFADLANIGGRWGGAITAGAFLSNFTKKYRWAHLDIAGTAWLQGANKGATGRPVSLLTQFLINQVK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA50F_BISBO
Sequence: SQISLRGS
What are the official names of this protein?
Pregnancy-associated glycoprotein 50F, EbPAG-F 50 kDa.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: NAPSA_MOUSE
Sequence: MSPLLLLLLCLLLGNLEPEEAKLIRVPLQRIHLGHRILNPLNGWEQLAELSRTSTSGGNPSFVPLSKFMNTQYFGTIGLGTPPQNFTVVFDTGSSNLWVPSTRCHFFSLACWFHHRFNPKASSSFRPNGTKFAIQYGTGRLSGILSQDNLTIGGIHDAFVTFGEALWEPSLIFALAHFDGILGLGFPTLAVGGVQPPLDAMVEQGLLEKPVFSFYLNRDSEGSDGGELVLGGSDPAHYVPPLTFIPVTIPAYWQVHMESVKVGTGLSLCAQGCSAILDTGTSLITGPSEEIRALNKAIGGYPFLNGQYFIQCSKTPTLPPVSFHLGGVWFNLTGQDYVIKILQSDVGLCLLGFQALDIPKPAGPLWILGDVFLGPYVAVFDRGDKNVGPRVGLARAQSRSTDRAERRTTQAQFFKRRPG
What is the function of this protein?
May be involved in processing of pneumocyte surfactant precursors.
What are the official names of this protein?
Napsin-A, KDAP-1, Kidney-derived aspartic protease-like protein, KAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ALP16_SCHPO
Sequence: MDGIMKNDLLWFGNHVFDLTPNSFDSDFVEQLSKFEGKEGLKRKLFDSSEYFQNFSFQVNDDLLGKDVILDISNQQLTPAVPGCETSSNSKLISASKEITSERKRAKSSVSPSYLTDSSPSDLSVENKVLLTCPSWDGENFKNLEARSPFISEAPSRVYDYFLHNQDWSPKPLFSALQVYPLATIFNCVAGLPQGFESTVFPWNKTSSTFELDPTISVSGMSDECFASIVQKFSAIGGLIKKALNEFSLYKTNISFYLSNFIVNGVLQYRKEFQRWLRLYEFRRFGLIGLSNFVNSFSSFFELISHFLIKSAQNLKGDSLLDFLFDYARSCQNTISYPIALQCLIYCSNPYFKRLELALKVSCAYGHIDSSLFLSLPRFFPSELCVSIEQCIQFLSLIREQKEIFNKNNKEFINPLNIRFAYSFNDINQACVIEERCNFSSLSFGNLEQTSVNNDSEEFETLLAKMNMTPDFNDNLLQLKFTDDVRNVCPLNLNVCCCIAEPIQSFILSFLRSTYKVLKNDFQVFDLLNFFHSTFLFQNYEFSDNVISLLKSRRLDKSDRNELAEDLNSDDRYNFISRLKKFIFMEKEKNGLSRSLSKSITFTLDSASVSEFEDVYPDLQFQCQVIGALRILFTDNSLNYYSKTFSYVLHLFQAQSDFESSVELKDRSIVTKTTIMSWSKYQGTKESLFQFLSIYIPECMLPFTKLLKSIYSPDCPTNIQNSAIKNAASVHEQCTKAIYQKVKELFDTMKLWESSIKVS
What is the function of this protein?
Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles.
What are the official names of this protein?
Spindle pole body component alp16, Altered polarity protein 16.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=And the microtubule organizing center (MTOC).
Protein: RL34_SHEPA
Sequence: MSKRTFQPSNLKRKRSHGFRARMATVGGRKVIARRRAKGRARLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: Y002_NPVOP
Sequence: MLEDKDRRIQELYASLLEMSERAVQYPAKGHQTPMLCVAREFNCLRAITGQKVHVTKMKRELTDAAELVIDAMRPNPQVDLNNFVNRV
What are the official names of this protein?
Uncharacterized 10.2 kDa protein.
Protein: LUKD_STAAU
Sequence: MKIEKLGKSSVASSIALLLLSNTVDAAQNITPKREKKVDDKITLYKTTATSDNDKLNIFQILTFNFIKDKSYDKDTLVLKAAGNINSGYKNSNPKDYNYSQFYWGGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNGSKSFSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGDKSSSNAGQNFLPTHQIPLLARGNFNPEFISVLSHKLFDTKKSKIKVTYQREMDRYTNQWNRSHWVGNNYKNQNTVTFTSTYEVDWQNILLKLIGTDSKETNPGV
What is the function of this protein?
Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells.  LukE-LukD is as effective as the Panton-Valentine leucocidin (PVL) for inducing dermonecrosis when injected in the rabbit skin, but not hemolytic and poorly leucotoxic on human blood cells compared to other leucotoxins expressed by S. aureus.  HlgA-LukD is a Ca(2+) channel inducer.
What are the official names of this protein?
Leucotoxin LukD.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTLE_BORPA
Sequence: MPDPRPLTPDQTHGRGHAEAAVDWEASRLYRLAQSERRAWTVAWAALAVTALSLIAIATMLPLKTTIPYLIEVEKSSGAASVVTQFEPRDFTPDTLMNQYWLTRYVAARERYDWHTIQHDYDYVRLLSAPAVRHDYETSYEAPDAPDRKYGAGTTLAVKILSAIDHGKGVGTVRFVRTRRDADGQGAAESSIWVATVAFAYDQPRALTQAQRWLNPLGFAVTSYRVDAEAGQP
What are the official names of this protein?
Type IV secretion system protein PtlE homolog.
What is the protein family that this protein belongs to?
Belongs to the virB8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RR8_ADICA
Sequence: MNNDAISTTVTSIRNANTKRKAMTRIPVTKMTRGIVQILLEEGFLKSVTEHTEGGKIFMDVKLRYFGKEKKPYVATIRYISKPGLRIYCDHIRIPKILGGMGIAILSTSYGLITDREARRRKTGGEILCHIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HIS2_MAGMM
Sequence: MNNLSPPSTVDILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKGRAARNEVAHEAADLIFHTLVGLAIMNIPPTEVMNVLSSRFGKTGLTRNQTPSVELEPSRRQFERRLHSKTIHLIFSSGITIDGLTRDISLDGMQLHVDYADKVRLLGEKGYFELSVQNKATFNANNLLVGLEIPTTMDNNPLMAAVHSARTYRFEFEIVRVTEDAIGLRIIGDKGMFSFALANEVFNDLM
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALC_STRPN
Sequence: MKGVNMEKQQPSKAALLSIIPGLGQIYNKQKAKGFIFLGVTIVFVLYFLALATPELSNLITLGDKPGRDNSLFMLIRGAFHLIFVIVYVLFYFSNIKDAHTIAKRINNGIPVPRTLKDMIKGIYENGFPYLLIIPSYVAMTFAIIFPVIVTLMIAFTNYDFQHLPPNKLLDWVGLTNFTNIWSLSTFRSAFGSVLSWTIIWALAASTLQIVIGIFTAIIANQPFIKGKRIFGVIFLLPWAVPAFITILTFSNMFNDSVGAINTQVLPILAKFLPFLDGALIPWKTDPTWTKIALIMMQGWLGFPYIYVLTLGILQSIPNDLYEAAYIDGANAWQKFRNITFPMILAVAAPTLISQYTFNFNNFSIMYLFNGGGPGSVGGGAGSTDILISWIYRLTTGTSPQYSMAAAVTLIISIIVISISMIAFKKLHAFDMEDV
What is the function of this protein?
Part of the binding-protein-dependent transport system for maltodextrin; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Maltodextrin transport system permease protein MalC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STBP1_POPEU
Sequence: GYTHAFESTFESKSGLQEYLDSAALAAFAEGFLPTLSQRSFNWGTDLGMESAELNR
What are the official names of this protein?
Stable protein 1.
Protein: ABDH_CITK8
Sequence: MPHQLLINGELVSGEGEKQPVYNPATGEVILEIAEASPAQVDAAVRAADRAFAEWGQTTPKARAELLLTLADVIEENAQTFAELESQNCGKPLHCALNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPVGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAEFAKDIFPPGVLNVLFGRGKTVGDPLTGHEKVRMVSLTGSIATGEHIIQHTAPSIKRTHMELGGKAPVIVFDDADLDAVVEGVRTFGFYNAGQDCTAACRIYAQKGIYDALVEKLGAAVASLKTGSPNDESTELGPLSSQAHLERVTKAVEEAKALGHINVVTGGQKLDGAGYYFAPTLLAGAKQEDAIVQREVFGPVVSMTVFDDEEQVLAWANDTQYGLASSVWTKDVGRAHRLSARLQYGCTWVNTHFMLVSEMPHGGQKRSGYGKDMSLYGLEDYTVIRHIMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: YR830_MIMIV
Sequence: MDFKKVFELGKFSDLELILVDKTNSLSINVHKVILYSAIPYFTTMFDNFKEKDCPSIKMEVIDVVVVSDIIKSFYGIETNNDPDWEYLLKEYISLDYLQLSCTLPDNIKVPDECFETLLDLVEIIGYNSKTIDMLANNLPNDFNLSTLPIELLREIESRYYDFYTMIIDRDNRMYSFNMCRKKLLQVTNKKYDDMYYFSVNDNLVLKASDKKIYTCNLSTKILKEHKENISMTDFHHHHLGETDIFIPENEAFKENIKNRIQKYLNNSSSNDGITEIYYSPDLTQIAVIFMLYQEESGEMYWLFIYDCKSDKLKKIYFKFDRISNVLFVPDGVIFYTHCSQKVIAWSNNKFQDVCCSLKHVKQITYDLGDNLLILTHNKFIVYSLNNKCVVNQVNCVLDKIEFVSKEIIIGYHKFYTNKSCVTNTKIIMYNILTGNETNKINVDLEIYKLVVVPDKARTKQKLKEYIESISTERISS
What are the official names of this protein?
Putative BTB/POZ domain-containing protein R830.
What is the protein family that this protein belongs to?
Belongs to the mimivirus BTB/WD family.
Protein: LPXA_BURM7
Sequence: MSRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYKDEPTRLVIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIGHDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGGDGDAAVKSLVDFVESSQRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIP_YEAST
Sequence: MFFNRLSAGKLLVPLSVVLYALFVVILPLQNSFHSSNVLVRGADDVENYGTVIGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFTDDERLIGDAAKNQVAANPQNTIFDIKRLIGLKYNDRSVQKDIKHLPFNVVNKDGKPAVEVSVKGEKKVFTPEEISGMILGKMKQIAEDYLGTKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKSDKEHQIIVYDLGGGTFDVSLLSIENGVFEVQATSGDTHLGGEDFDYKIVRQLIKAFKKKHGIDVSDNNKALAKLKREAEKAKRALSSQMSTRIEIDSFVDGIDLSETLTRAKFEELNLDLFKKTLKPVEKVLQDSGLEKKDVDDIVLVGGSTRIPKVQQLLESYFDGKKASKGINPDEAVAYGAAVQAGVLSGEEGVEDIVLLDVNALTLGIETTGGVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVMIKVYEGERAMSKDNNLLGKFELTGIPPAPRGVPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQEEIDRMVEEAEKFASEDASIKAKVESRNKLENYAHSLKNQVNGDLGEKLEEEDKETLLDAANDVLEWLDDNFETAIAEDFDEKFESLSKVAYPITSKLYGGADGSGAADYDDEDEDDDGDYFEHDEL
What is the function of this protein?
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.  Is required for secretory polypeptide translocation.  May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.
What are the official names of this protein?
Endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein homolog, GRP-78, Immunoglobulin heavy chain-binding protein homolog, BiP.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: GYRA_MYCGA
Sequence: MNPNDKNNIKELLNKTVVKEASITKELETSFMEYAMSVIVSRALPESRDGLKPVHRRVLYGAYTSGLTHDKPYRKSAQIVGHVMGKYHPHSDSAIYETMVRMAQPFSLRYMLIDGHGNFGSIDGDSAAAMRYTEARLSKISAEMLRNIDKDTVDFVDNYDASEQEPIVLPSLFPNLLANGSSGIAVGMATNIPPHNLSELIGGIKHLLVNENATIEELKEFIKGPDFPTAAEILGETGINEYFNTGRGSVSVRAKSEIEELANNKSNIVITQIPYMVNKANLINKIAELVKTEQIQGIADLRDESNREGIRIVIETKRDVIPEVLLNQLYKSTQLQTNFSVAMLALVNNQPKVLNLKEALQIYIDHQFDILLRKTNFELKKAKASAHIVEGLVIATNNIDDVIETIKNAKDNEDAKNTLMTKYELSDLQAKAILDMRLRSLSGLERENLQKELAKLKELIKDLEEILQNKERRIKIISDQLDEIDHKFGDERRTKICYGLNSTIDNEQLIPVETVVITRSSKGYLKRIPISAYKVQHRGGVGVKGMNTYEDDDVESLIVCSTHSDLLFFTNYGKVYRIRAHQVPLGSRISKGIPAINLISIEKDEKLMSLLSINDYDSGYFFFSTKKGLVKRVKASEFSRIQNNGKIAIKLTENDSLFKVIKTAGDEEIYIGVSSGLLVRFKEDVVRSMGRTAQGVIGVKFKNPNDEVIGLSSSHEGSLLLAVCEKGVGKMTDREEYRMTNRGSKGVITIKVTPKTGNIINTQLVNGNEELLMISSTGKIVRVPLAEVSEQGRNTSGVKLISLNEKETLQSVAIFDVEQDDSQQVGSDNPDTELSSDDSNQDQDKE
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_UREPA
Sequence: MAKIIEEMINKKGLLIDDYELYGNEIAKIKSIKKLNKKDSKLIVITSMNPNPAGEGKTTTAIGLVDALNKHGYKAIGALREPSMGPVFGMKGTGSGGGLSFLKPFDKINLHFSGDFHAITAANNLIVAVIENEIHNRSSMQIDSQKILIKRCLDVNDRSLRNIEYDINHQQTKSGFNITAASDLMALFCLAHDHKDFEDKLAQTIVAYNIVNQPIRICDLELTKAIMAILEDALYANLVRTNEDNPVFVHGGPFANIAHGCNSIIATKNALALGDYVVTECGFGSDLGLEKFMNIKMASLNLKPDLIGLVISLKSIAYHAQTNEKDYVKQGFANVLCHINHIKKYNVSFIVYINVNTNTDSEEDLLTLEKLLDEHQIEHARSYAYSYGSKKSEEITKKTITLTNQINDHELKLIYDIKDHLSYKLKKICENVYGADGYELSYEAKEQLNRYEHLDFYLCIAKTPYSISDDAKLLNNPKNFKIHIERFEINYAAKLIIAITTTIYRMPGLNKEPAAKNFVMK
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: NFUA_SHIFL
Sequence: MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEATDTALKFDLLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVADDAPLMERVEYMLQSQINPQLAGHGGRVSLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEKQLLNEFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: MNMA_WOLPM
Sequence: MLKEFEIEPLLKDKAPHQTKAVVAMSGGVDSSVAAALLHNLGYKVVGVTLQLYGTDGNANARKGACCAGQDIYDAKRVAESVGFPHYLLNYEEIFKKEVIEDFASTYMRGETPIPCVRCNQTVKFRDLLQVTKNLGADVLVTGHYVRRLEKNGEVKLCRSIDKSKDQSYFLFATTQEQLKLLRFPLGGFYKSDIRKLAKYFSLQISEKQDSQDICFVSESYSKTIAKLAPQSVQKGKIVDVNGKVLGEHSGIVNFTVGQRKGLGIAHNEPLYVIKINTENNEVIVGPINVLMQKKILIKELNWLEQPKEGMEVTVKLRSSHVGSLATIHSTDEKNKACVILNDDYFGISPGQACVAYKDEQVIGGGWICS
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_ALISL
Sequence: MSKRDFYEVLGVSRDASERDIKKAYKRLAMKFHPDRNQGDETAPEKFKEVKVAYEILTDAQKRAAYDQYGHAAFEQGGMGGGGGFGGGQGDFGDIFGDVFGDIFGGGRRGGQQRAQRGSDLRYNMELTLEEAVRGCEKDIEIPTLAACEPCDGTGAKKGTSSTTCSTCHGQGQVQMRQGFFAVQQACPTCHGKGKIIKDPCNSCHGDGRVQKTKTLNVKIPSGVDTGDRIRLSGEGEAGEHGAPAGDLYVQVHVKEHNIFDRDGNNLYCEVPVSFTMAALGGEVEVPTLDGRVSLKVPLETQTGRMFRMRGKGVKGVRTHSAGDLIVKLIVETPVKLTKRQRELLKEFQESFDGKDAKKHNPKSEGFLSGVKNFFDDLTK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_METTH
Sequence: MDGERMMLRVIDNLIVREKLTTIRCRGIDPASFRRGVTDIGRYMAYEFADTLKWREVEVETPLGTASGVEITDRDRIVLLSILRASLPFTEGVMKVFPEAEHGIIGARRSDEPPFRVSIDYIRVPELDDKILVIADPMLATGNTMIGILEALEAHGSPARTVVFNIISSRMGLDRVLQRGIDVYTCGVEEEVNDMGYIVPGLGDAGDLAFGRPSD
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: EEVS_STIAD
Sequence: MAHIKVVGGGTSVRGSTLQVSAQADFGYGVHNEEGLFDPGQPLLLELCRDARMLVCISPSVDRLHGERIRQYFRTHFAPEQYRFLVLSTSESNKSIENVLRICEAAKAFWLDRHGLLVAIGGGIVLDMVGFAASIYRRGIRYIKVPTTLVGQVDVAVGVKTGVNLSGSKNLIGTYYPAYATLNDRGFLSTLPAREMRCGLAEIIKMGLVCDPEIFTALEAHFLPPVSRHLEHPLPQEAVLGAMVRMIEELQPNLFELNLERLVDFGHTFSMSLETVSGYAHAHGEAVAMDMALSACLSNELGILGEAEFERILALLEVVGLPVFDEALCSVDAMWQALMEVNVHRGHRINLVIPARIGEGMFLHRLEDVPRDALARAIRRMSVLSQRHAVAALGSAGEPLERASGA
What is the function of this protein?
Catalyzes the cyclization of D-sedoheptulose 7-phosphate to 2-epi-5-epi-valiolone.
What are the official names of this protein?
2-epi-5-epi-valiolone synthase, EEVS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. EEVS-like family.
Protein: NRDR_HISS2
Sequence: MRCPFCAMEETKVIDSRLVSDGYQVRRRRECGYCHERFTTFESAEVIVPKIIKNDGSREPFDEDKLRRGIQHALEKRPVSSDDVEKAISRIIYQLRATGERDVKSQDVGRLVMAELKELDKVAYIRFASVYLSFDDINQFTNEIEKLKD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.