PharMolix/UniProtQA huggingface dataset:
Protein: APT_STRP2
Sequence: MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIGDYDYKVLMHY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTBC_METBA
Sequence: MSKEELLQELADAIISCKKDTVLAVVEKAKGELEPSEIIEKGLAAGMNEVGVRFERGKLFLPHVMMAADAMTAGVAALKDLMPEGASGSKLGVIVNGTVEGDVHDIGKAIVSTMLQSAGFEVHDIGRDVPIRNFIEKAKEVNADMIGISALMTTTLQGQKSVIELLKEEGLRDKVKVMVGGAPATQAWADKIGADCYAENATEAVAKAKELLA
What is the function of this protein?
Acts as a methyl group carrier between MtbB1 and MtbA.  Binds 1 corrinoid cofactor per protein, is subsequently demethylated by MtbA.
What are the official names of this protein?
Dimethylamine corrinoid protein.
What is the protein family that this protein belongs to?
Belongs to the methylamine corrinoid protein family.
Protein: RPOY_LACH4
Sequence: MIYKVLYQKDKIVNPRRETTQTLYMEADNMVEARSTVEDNTPYNIELIQELTGNSLAYEKEHADFKLTKFDKK
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: ACT_ENTH1
Sequence: MGDEEVQALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHVSVMAGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVNNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKANREKMTQIMFETFNTPAMYVGIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGFSLPHAILRLDLAGRDLTDYLMKILTERGYAFTTTAEREIVRDIKEKLCYVAEDFNEEMQKAASSSELEKSYELPDGQVITVGNERFRCPEALFQPSFLGMECNGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTSMYPGINTRLEKEMIQLAPPTMKIKVIAPPERKYSVWIGGSILASLSTFQNMWITKEEYDESGPAIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity).  Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity).  Has ATPase activity (By similarity).
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
Protein: PRSA2_STRP8
Sequence: MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSDFYNETKNTELAQKAMLSLVISRVFETQYANKVSDKEVEKAYKQTADQYGTSFKTVLAQSGLTPETYKKQIRLTKLVEYAVKEQAKNETISKKDYRQAYDAYTPTMTAEIMQFEKEEDAKAALEAVKAEGADFAAIAKEKTTAADKKTTYTFDSGETTLPAEVVRAASGLKEGNRSEIITALDPATSKRTYHIIKVTKKATKKADWKAYQKRLKDIIVTGKLKDPDFQNKVIAKALDKANVKIKDKAFANILAQFAKPNQKQPAQK
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA 2.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ATPD_RICB8
Sequence: MNKDILTQNYAVALFDNAKSDNTQDKILEEVNLVTSIIEDNIEVKELLSSPIVNKVDKIGVINSLVKNIKISKIMQNFLLLLIKNSRTSILADIANTYSKLLYESKNIKIVQVISANKLKPTEQEWVKTNIEKELKQETKINFEIDPTIMGGIVIKYDSILQDYSIKGSLDKIAKALQSVNVFDCHPVA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y186_PSEPW
Sequence: MKISEWPAEERPREKLMQRGVGSLSDAELLAVFLGSGVRGRNVVELARGLLVKFGGLRQLLEADRDAFVGELGLGPVRYGQLQALLEIGRRNLATSIERDCALESPSAVRRYLKAMLRHEPSEVFGCLFLDSKHRPLAFEILFRGTIDRASIYPREVVRRSLMHNAAALILCHNHPSGNSEPSQDDVHMTLALKRGLALIDVRVLDHIIVGDGEPLSMVEQGWIVA
What are the official names of this protein?
UPF0758 protein PputW619_0186.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: EPMA_SALTI
Sequence: MSETATWQPSASIPNLLKRAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLFPFETRFVGPGHSQGINLYLMTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQVLDCQPAESLSYQQAFLRHLEIDPLSADKTQLREAAAKLDLSNIADTEEDRDTLLQLLFTMGVEPHIGKEKPTFIYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQQPIDQNLLDALAAGLPDCSGVALGVDRLVMLALGAESLADVIAFTVDRA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'.  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34'.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: PANB_STRMK
Sequence: MSTHADSKPWTVPALAEAKRNGQKLVMLTAYDAGFARTFDANGVDLILIGDSLGMVVQGHDSTLPVTVADMVYHTRAVARVLQRALLVADLPFGADATPERALDASLQLLQAGAEMVKIEGAGFKVDIIRYLVEREIPVCAHLGLTPQSVLRLGGFKIQGRGDAARQLVEDARAVAAAGASIMVLECVPTPVAAEVTAAVEVPTIGIGAGPQCDGQVLVLHDFLGLDSGHRRPKFVKDFLAEGGSVAGATRAYADAVRDGSFPDEQHAYAS
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_PELPD
Sequence: MPRRREVPKRNILPDPKFHDKTVAKLINVLMLAGKKSIAESILYGALDIVAQKTNDEAVKVLKKSLDNIKPALEVKSRRVGGSTYQVPIEVRPDRRVSLAMRWLIKYSTLRSEKTMKDKLAGEILDAYNSRGAAVKKREDVHKMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: G6PI_CUTAK
Sequence: MPTLIDATSTPAWGTLSGLKSRFADGPHKLRRLFDADPHRAERYTLDVADLHVDLSKNLLTDEIRDALLELAAQMRVTERRDAMYAGEHINVTEDRAVLHTALRRSRTDELHVDGQDAVADVHEVLDKIYAFADKVRSGEWKGVTGKPIRTVINVGIGGSDLGPVMAYEALKPYVKDGLECRFISNIDPTDAAVKTADLDPETTLVIIASKTFTTLETLTNARCVRAWLLDGLVAAGAISDTEQARRDAVAKHFVAVSTALDKVEEFGIDPVNAFGFWSWVGGRYSVDSAVGTSLAVAIGPKGFEDFLAGFHAVDEHFATAEPERNVPLFMGLLNIWYTNFWDAHSHAVLPYSQYLHRFPAYLQQLTMESNGKSVRWDGSAVTTDTGEIFWGEPGTNGQHAFYQLIHQGTRVIPADFIAVANPVHPTKDGGTDVHELFLSNFFAQTAALAFGKTADEVRAEGTDEAIVPARVFAGDRPTTSIMADELSPKVLGELIALYEHITFVQGVVWGIDSFDQWGVELGKKLALQIAPAVSGNDEALATQDPSTQGLVTWYREHRR
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP2_CHLCV
Sequence: MVRVSTSEFRVGLRIEIDGQPYLILQNDFVKPGKGQAFNRIKVKNFLTGRVIERTFKSGESVETADVREQQMRFLYSDQEGATFMDDETFEQEMIFWDKIENIRQWLLEDTIYTLVLYNGNVIGVEPPIFMELTIAETAPGVRGDTASGRVLKPAVTNTGAKIMVPIFIEEGEVVKIDTRTGSYESRVSK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
What are the official names of this protein?
Elongation factor P 2, EF-P 2.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOA2_RHIWR
Sequence: MSFDVGKDKLYIQDVTLRDGMHAIRHMYGIDHVRAIAQALDEAGVDAIEVAHGDGLNGASFNYGFGAHTDWEWLEAVADVLTRSVLTTLILPGVGTVDELRRAYDIGVRSVRVATHCTEADVSKQHIGIARDLGMDVSGFLMMSHMIEPEALAQQALLMESYGAQCVYVTDSGGALDMDGVRARFQAYDRVLRPETQRGMHAHHNLSLGVANSIVAAQQGAVRIDASLAGMGAGAGNAPLEVFIAAVDRKGWNHGCDVNALMDAAEDLVRPLQDRPVRVDRETLALGYAGVYSSFLRHAEKAAADYGLDTRTILVELGRRKMVGGQEDMIVDVALDLVRERGAAA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 2, HOA 2, 4-hydroxy-2-keto-pentanoic acid aldolase 2, 4-hydroxy-2-oxopentanoate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: EF1A1_SCHPO
Sequence: MGKEKGHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEATELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYNVTVIDAPGHRDFIKNMITGTSQADCAVLIIGGGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAVNKMDTTGWSQARFEEIVKETSNFIKKVGFNPKTVPFVPVSGFQGDNMIEPTTNMPWYQGWQKETKAGVVKGKTLLEAIDSIEPPARPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKPGMIVTFAPAGVTTEVKSVEMHHESLDAGLPGDNVGFNVKNVSVKDIRRGNVCGDSKNDPPMGCASFTAQVIILNHPGQISAGYSPVLDCHTAHIACKFAELIEKIDRRSGKKIEESPKFVKSGDACIAKMVPSKPMCVEAFTDYAPLGRFAVRDMRQTVAVGVIKAVEKVAPGAAKVTKAAVKAGAKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha-A, EF-1-alpha-A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BORE2_DANRE
Sequence: MAPRRTRKVSQDSDGQADDQHSFEQKIRLTKRKELFIQQFEKEAQDRINEMEANLNKLLATVDRVFKIELMKMPLSLHTTLIKDLMNDDDTSVGEVTMALKCASPEIQKPLSRKPSKKALNALAGQQRSSSQSKTPIEGQKKPTKKTLHSSKSTGSLRCASTINAKRTQGRVVKLSDQANALGVQFRQTSRSVGDELMMATATIVTSHGETLFLSEDNKDEINVELLDDAAVNQMRKIKELMDYLCNKVRINNTC
What is the function of this protein?
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.  The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity).
What are the official names of this protein?
Borealin-2, Cell division cycle-associated protein 8.2, Cell division cycle-associated protein 9, Dasra-A, DrDasraA.
What is the protein family that this protein belongs to?
Belongs to the borealin family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis.
Protein: CPXT1_MICAN
Sequence: MTHPTDIKTLARWMAADFSNQEQAFANPPFFAHIRVCMRPLPDELLNGTSLFLEQAYDFMLNTPYRLRVFKLSLVDDHIELENFKVKEEANFFGASREPQRLKNLTLDLLEPMLGCDMNVTWTGNSFKGVVKPGKQCLVFRKDRMTYLDNSFEISERGLISVDRGLDPETDQLVWGSIAGPFEFVRRTSFAEEV
What is the function of this protein?
Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.
What are the official names of this protein?
Chromophore lyase CpcT/CpeT 1.
What is the protein family that this protein belongs to?
Belongs to the CpcT/CpeT biliprotein lyase family.
Protein: NU4C_POPAL
Sequence: MNSFPWLTIFVGLPISAGFLIFVFPHRGNKVIRWYTIFICVLELLLMTYAFSYYFQLDDPLIQLTESYKWINFFDFYWRLGIDGLSLGPILLTGFITTLATLAARPITRDSRLFHFLMLAMYSGQIGLFSSQNLLLFFIMWELELIPVYLLLAMWGGKQRLYSATKFILYTAGSSVFLLMGALGIAFYASNEPTFNFETSANQSYPVTLEILFYIGFLIAFAVKSPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLVRINMELLSHAHSIFSSWLIIVGAIQIIYAASTSSGQKNLKKRIAYSSVSHMGFTIIGIYSISDMGLNGAILQIISHGFIGAALFFLSGTSYDRIRLVYLDEMGGMATLMPKIFMMFSILSLASLALPGMSGFFAELVVFFGIITAKKFFLMPKILITFVTAVGTILTPIYLLSMLRQMFYGYKLFNATNSYFFDSGPRELFVSIAILLPVISIGIYPDFVFSLSVDKVEAILSNYFYS
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ORF5_SPV1R
Sequence: MINLLVENNNSNWDKIFSFVFDIFLFIFDVIWNTKLPMTNTSIAYFLIFFMVIKLSIYAIHGTSTQYNNLGSTVNNGVSQVYSSTVRGVSDTKQGMQKHIKERKQFKINRNKKQLSSLAKQAKTREQGYRRVHK
What are the official names of this protein?
Uncharacterized protein ORF5, Gene 5 protein.
What is the protein family that this protein belongs to?
Belongs to the plectrovirus ORF5 family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: HIS3_LACCB
Sequence: MITLDWEKANGLITTVVQDATTKQVLMVAYMNQESLAKTMATGETWFWSRSRKTLWHKGATSGNIQTVKTIAVDCDADTLLVTVDPAGPACHTGHISCFYRHYPEGKDLT
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CG121_CANGA
Sequence: MNFKIPQFPDFEISITAFENVTNSESIRSKVATLPYAFLDARMIYSQEQLYAALYRVLVEQNYNKLRTKTIHSEIMLCLSPTSNIGDAFKKFGIKEDSSTVICLHIKDRSDEPELPSLSSIVEGQEISLSKEFINQHRDIGMVGHVYKINGEMIENSTEDQVSSMIVNMIQLRGL
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.  CGI121 is not required for tRNA modification (By similarity).
What are the official names of this protein?
EKC/KEOPS complex subunit CGI121.
What is the protein family that this protein belongs to?
Belongs to the CGI121/TPRKB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: TX29A_PHOKE
Sequence: ECIGHRRSCKEDRNGCCKLYTCNCWYPTPDDQWCKCLL
What are the official names of this protein?
U9-ctenitoxin-Pk1a, U9-CNTX-Pk1a, Venom protein PKTx22C1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 02 (plectoxin) family. 09 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: 6PGL_SHISS
Sequence: MKQTVYIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRIAPDDGALTFAAESALPGSPTHISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAGPRHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTCWAADIHITPDGRHLYACDRTASLITVFSVSEDGSVLSKEGFQPTETQPRGFNVDHSGKYLIVAGQKSHHISVYEIVGEQGLLHEKGRYAVGQGPMWVVVNAH
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: ARGC_BACTN
Sequence: MIKAGIIGGAGYTAGELIRLLLNHPETEIVFINSSSNAGNRITDVHEGLYGETDLRFTDQLPLDAIDVLFFCTAHGDTKKFMESHNVPEDLKIIDLSMDYRIKSDDHDFIYGLPELNRRATCTAKHVANPGCFATCIQLGLLPLAKNLMLTGDVSVNAITGSTGAGVKPGATSHFSWRNNNISIYKAFDHQHVPEIKQSLKQLQNSFDSEIDFIPYRGDFPRGIFATLVVKTKVALEEIVRMYEEYYAKDSFVHIVDKNIDLKQVVNTNKCLIHLEKHGDKLLIISCIDNLLKGASGQAVHNMNLMFNLEETVGLRLKPSAF
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_CERS1
Sequence: MPDLYAYTDGACSGNPGPGGWGVLMLAREGEAVVKERTLQGGEVLTTNNRMELMAAISALEALTRPTEITIVTDSAYVKNGVTTWIHGWKRNGWKTADRKPVKNAELWERLDAAQQRHKVVWRWIKGHAGHAENERADELARAGMAPFKTR
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBH1_HUMAN
Sequence: MRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTNRDPNHGLYPKPRTKRGSRGQGSQRCIPEFFLAGKQPCTNDMAKSNSVGQDSCQDSEGDMIFPAESSCALPQEGSAGPGSPGSAPPSRKRSWSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPREARQEAEDSTSRLSAESGETDQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICSLPSEVLRHVFAFLPVEDLYWNLSLVCHLWREIISDPLFIPWKKLYHRYLMNEEQAVSKVDGILSNCGIEKESDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLPEAEACVRQHLPDLYAAAGGVNIWALVAAVVLLSSSVNDIQRLLFCLRRPSSTVTMPDVTETLYCIAVLLYAMREKGINISNRIHYNIFYCLYLQENSCTQATKVKEEPSVWPGKKTIQLTHEQQLILNHKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAERVFPSNVICKTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFASADEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECTEEAHQMTHDGYLKLWQLSKPSLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCKRVRKKTLVGGNHQSGIRGDAKGQVALLSRTNANVFDEAVRVTEGEFPSRIHLIGGIKSFGLDRIIDIWILLQPEEERRKQNLVIKDKFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVVEKYNIRIPELVQRIEKCHIEDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLPQLPHFRVESFSEDEWNLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAMERTVENIVLPRHEALLFLVF
What is the function of this protein?
3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192).  Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316).  Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013).  Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361).  In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578).
What are the official names of this protein?
F-box DNA helicase 1, hFBH1, DNA 3'-5' helicase 1, F-box only protein 18.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Accumulates at sites of DNA damage or replication stress (PubMed:19736316, PubMed:23677613). PCNA is required for localization to DNA damage sites (PubMed:23677613). Localizes to the nucleoplasm in absence of DNA damage (PubMed:23677613).
Protein: RT05_BOVIN
Sequence: MAAAVRAAGFLPALCGASAGRLWSRQLYLNTFPTASIWALKAVPSNGPSSSAGARGRCRSTHLGPALQTQCCTPAPGNVTAQQYRSYSFFTKLTADELWKGALAETGAGARKGRGKRTKRKRRKDLNRGQIIGEGRRGFLWPGLNAPLMKSGAIQTITQRSKEEQEKVEADMVQQREEWDRKRKMKVKRERGWSGNSWGGISLGPPDPGPNGETYDDFDTRILEVRNVFNMTAKEGRKRSVRVLVAVGNGRGAAGFAIGKATERADAFRKAKNRAVHYLHYIERYEDHTIYHDISLTFKRTHIKMKKQPRGYGLRCHRAITTICRLIGIKDMYAKVSGSVNMLSLTRGLFQGLSRQETHQQLADKKSLHVVEFREECGPLPIVVASPQGALRKDPEPEDEVPDIKLDWDDVKAVQGMKRSVWSGLKRAAT
What are the official names of this protein?
28S ribosomal protein S5, mitochondrial, MRP-S5, S5mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LEUC_PROM3
Sequence: MSSGTLYDKVWDLHRVADLPGGSTQLFVGLHLIHEVTSPQAFAALQDKGLPVRCPERTVATVDHIVPTISQKRPFADPLAEEMLSTLERNCANYGIVLCGLGSGRQGIVHVIAPELGLTQPGMTVACGDSHTSTHGAFGAIAFGIGTSQVRDVLASQSLAMNKLKVRRIWVDGQLGSGVHAKDLILHVIRSLGVKAGVGYAYEFAGPAIDVLSMEERMTLCNMAIEGGARCGYVNPDGVTFDYLQGRFYAPTGEAWHRAVAWWSSLASDPNAVFDDEVMFDAASIAPMVTWGITPGQGIAVDESVPTIDSLEPNERPIAEEACRYMDLEPGMAIEGVPVDVCFIGSCTNGRLSDLKAAAAIAKGRHVAQGIKAFVVPGSEQVARAAEAEGLDGVFRKAGFEWREPGCSMCLAMNPDRLEGRQISASSSNRNFKGRQGSSRGRTLLMSPAMVAAAAITGQVTDVRKLISNTVPSKSFHQ
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: O16N_CONAB
Sequence: VIIIAVLFLTACQLIATASYARSERKHPDLRLSSRNSKLSKRCLGSREQCVRDTSCCSMSCTNNICF
What are the official names of this protein?
Conotoxin AbVIN.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LPXB_RUEPO
Sequence: MRPAGPVPVCCRAGRLMRVFILAGEPSGDRLGGALMAGLRQLCPDVQFDGVGGPAMESEGLSSRFPMAELSIMGLVEVLPKYFHLKRRIAETAQAVLAMRPDVMITIDSPDFSLRVARLVKDASDIRTVHYVAPSVWAWRPGRADKMAKVIDHVLALLPFEPPYMERAGMECDFVGHPVVTEPEATGADIAALRTELGLGAAPVLLALPGSRRGEVERLAPVFGAALRRFLPEHPDMRVVVPVVPHVADQVAQQVAEWPGAPVLVDPRGLAPAQAAMRKRAAFAAADLALAASGTVSLELAAAGTPMVIAYKVNWLTQKIAERMVTIDTVTLVNLVSETRVVPECLGPACTPENIAARLAAVHADPAAQDAAMRLTMERLGRGGTPPGLRAAQAVLDRLPG
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: HIS2_POLSJ
Sequence: MSSNDSLQRLAQIIESRKPANGGDPGTSYVARLLHRGPDAFLKKIGEEATETVMAAKDLDHGGPTPELRAKLVGEVADLWFHSLIALAHYGLQPADVIAELERREGTSGIEEKALRKVQNRDAAEKS
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.