PharMolix/UniProtQA huggingface dataset:
Protein: EFG_NITHX
Sequence: MPRQHAIEDYRNFGIMAHIDAGKTTTTERILYYTGKSHKIGETHEGAATMDWMAQEQERGITITSAATTAFWNGKRLNIIDTPGHVDFTIEVERSLRVLDGAVCVLDSNQGVEPQTETVWRQGDKYKVPRIVFCNKMDKTGADFYKCLADIVDRLGARPVAVQLPIGAESAFKGMVDLVRMKALVWNIDSAGAMYDIEEIPADLADKAREYREKLVEAAVELDDNAMAAYLDGTEPDEATLKNLIRKGVITGAFYPVLCGTAFKNKGVQPLLDAVVDFLPSPLDVPAIKGTDDKGNEILRHADDKEPMSLLAFKIMDDPFVGTITFCRIYSGILQSGTGVVNSTREKKERIGRMLLMHANNREDIKEAYAGDIVALAGLKEARTGDTLCDPAHPVILEKMEFPDPVIEIAIEPKSKADQEKLGVALAKLAAEDPSFRVSTDQESGQTILKGMGELHLDIKVDILRRTYKVDANIGAPQVAFRERVTKRVEHSYTHKKQTGGTGQFAAVTLIVEPSEPGKGYEFESKIVGGAVPKEYIPGVEKGIESVLGSGVVAGFPVVDVKVQLIDGKFHDVDSSALAFEIATRACFREALQKGKSVLLEPIMKVEVVTPEDYTGSVIGDLNSRRGQIQGQDMRGNANVINAMVPLMNMFGYVNNLRSMSQGRATFTMQFDHYAEAPANVSAEVQKKFA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MORN3_BOVIN
Sequence: MPIFKCPQKSEPLWKEWDQKAQKNGLRHQVFAVNGDHYVGEWKDNVKHGKGTQVWKKNGAIYEGDWKSGKRDGYGTLSLPDQETGKYKRAYSGWWKGDKKCGYGIQFFGPKEYYEGDWCGNQRSGWGRMYYSNGDIYEGQWRNDKPEGEGMLRLKNGNRYEGNWQRGVKNGSGRFFHLDHGQLFEGFWVDDVAKCGTMIDFGRDEAPQPTQFPIPEVKILDPDGVLEEALAMFKKTKEEGD
What are the official names of this protein?
MORN repeat-containing protein 3.
Protein: Y1473_CAUVC
Sequence: MIDRKPFDKLGGADHGWLKAKHHFSFASYYDPNNMNWGALRVWNDDEIAPNTGFPPHPHSDMEIITYVRDGAITHQDNLGNKGRTVAGDVQVMSAGSGIRHAEYNLEPETTRIFQIWIEPKSFGGAPSWGSKPFPKGDRSGKFVTLASGFSDDADALPIRTDARVLGATLKAGETTTYALGKDRSGYLVPAAGVVEVNGVRLNARDGAGIKDEAVITITALEDAELVLVDAA
What are the official names of this protein?
Pirin-like protein CC_1473.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
Protein: ILVC_HAES1
Sequence: MGNYFNTLNLRQQLDQLGRCRFMEREEFADGVNFLKGKKIVIIGCGAQGLNQGLNMRDSGLDIAYALRPEAIEEKRASFQRASENGFVVGAYQQLIPTADLVINLTPDKQHSKVVADVMPLIKQGAALGYSHGLNIVEVGEKIRQDITVVMVAPKCPGTEVREEFKRGFGVPTLIAVHPENDPKGEGLAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLVCYDKLIADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFSLSEQIKEKLDFLFKKHMDDIISGEFSRVMMEDWANGDANLLKWREQTGKTAFENAPKGENIKISEQEYFDHGVLMVAMVKAGVELAFDTMVETGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFANVAAPILAKEIIPTLKRGDLGESTPATEIDNILLRDVNDAIRQHPIELIGQELRGYMTDMKRISSQG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: Y777_MYCSS
Sequence: MADSSFDVVSKVDRQEVDNALNQAAKELSTRFDFRGTDTTIAWKGEEAIEIVSSTEERVKAAVDVFKEKLVRRDISMKAFDAGDPQPSGKTYKVNGTIKEGITSEQAKKITKIIRDEGPKGVKAQIQGDEIRVSSKKRDDLQTVISLLKQADLEVALQFVNYR
What are the official names of this protein?
UPF0234 protein Mmcs_0777.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: SWP32_NOSB1
Sequence: MKTSVVILAMSYITSIFANNSYDFCDGEFAISEKDDKCGFSFNPCTLYKQIQKEYSNCVILRFYLKAISNMLESICDNNKRCLPFSIDSLYRPLYNREQFKHKHHHTLYALFRNCLYLVNPIYFKEYQDALACNQLDVCYFLIRRTVCPKYGVTKYIECLKKRCEDRFDEKELAIFICDSETFVNIKLEIDACRKICPADCTLDICKIYSLDFWERRDLLKAIFDYHYCHVLSSDNTRDEIIKKIEEIYLNGTERDIKFTSFIIYQLFTDLVACKSSDKNIKRILDLICLYEKKDKCPSGVMVMIEFFVKVCSYQC
What are the official names of this protein?
Spore wall protein 30.
What are the subcellular locations of this protein?
Spore, perispore.
Protein: CDV3A_XENLA
Sequence: MAEPQEKSLDDFFAKRDKKKKKDKGVSGSAAGSRGSARPPDGAPSSSSSMSGAGKGVKKEKSGKSDNPDQLQEKEDDEWKEFEQKEVDYSGLRIQSLQLSNEKEDDENEKKEEQGADWEETGGYGTDKSSGPWNKTSQAQAPISAVTEAPEPVHTGGVYRPPAARASVSTRKPQGPPEIYSDTQFPSLQATAKHTESRREKEMEKTFEMVKHKNRARDEATKNQALRLQLDNQYAVLGEQ
What are the official names of this protein?
Protein CDV3 homolog A.
What is the protein family that this protein belongs to?
Belongs to the CDV3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y470_PECAS
Sequence: MFRWGIIFLVIALIAAALGFGGLAGTAAGAAKIVFVVGIILFLVSLFTGRKRP
What are the official names of this protein?
UPF0391 membrane protein ECA0470.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CUPI_DICDI
Sequence: MSNKLNKQISTEISECYLKEKPQQSFKKSNEIKMSNELINKISNEISNCYLKEKPQQAKKETKKKSIRSLPTDLPPLKSITPLKSWIFLQCRQMDANGNPLCCGVSGRYTQPGTQCILWQIDENDPSQLWQISKDGHLVSLLAGNYVMDYNNDGTNLAIANGWNNYTSQIWTYNSSTGQIENSNYPNTCLGIKGAFNEPITPTNGTELVIDQPIDNNNLCFQWDLVPSYPLNTILTSPPQAFPTFPGDQNTAFIEISQYLSNVDDIRSQYTNLSVSLPFFQSQMSAMSYPSYLSHEEFDFVRDQLSTEFNYAQEIINLIGNYESFHNELFADNSARLNQLATLCQLEIGSDINAMGSVIQVFSGMMYSILEALPGVGPILGNVLQTAVNIGVAASDGHSTIQPDPFQVALSNLWDTLSTNYEALLSNVSNMETMLLQDWGMMVTTHGLIETLSGPNSLAWQSSMTGDLISAAVPGYEISLLQILMPSKYQIYRYDLANNGNVGLPDDIPSSCLWTDPNDSNITYFIADNETTKVYPDDSLMSLIWGNGVSEQEFFLSANGWNFCMSLLNDNIGSGAPTISNNTSTALNFKIQFSPTQIYNYDVPTHSSNFTTEFDNTAIENSYYQITIYDNTNSWVASISVRVDIFVMRGADVSVLSSSCADGYYLGTPNCLQGSFAHSFTGSINIPIFEN
What are the official names of this protein?
Putative calcium up-regulated protein I.
What is the protein family that this protein belongs to?
Belongs to the cup family.
Protein: SYV_WOLPM
Sequence: MLKEKYGFKEVEDKCNILWEGSKVYRWNGEKDNTFTIDTPPPTISGKLHIGHIFSYCHTDFIARFQRMLGKDVFYPIGFDDNGLPTERLVEQTYKTRAKEVGREKLIEMCHEVIEKSKQEFKELFKSVGISYDWDLEYHTISKETVTLSQMSFIDLYNKGYAYRKMQPILWDPVDKTAIAQAEIEDKVFESSLNTIVFSTEENEQINIATTRPELLPACVAVFCHPEDARYTHLIGKTTVVPITETKVPIIADDKVKIDKGTGLVMCCTFGDELDIYWQQKHNLPMKIIIDQDGRMSLHSVHGQKEEIWIPVSGHWDDTIGATGMTGERATQMTKEGGCDQKEEWIPVSATRMTDDILNEINGLKVTAARKRIIEILTEKGLLVESTNISHSVKCAERSGAPLEILPTYQWFIKTLEQKAQILDKVKECNWHPSNMRKRMEVWIEGLNWDWCISRQRYFGVPFPAWYSKRKGEEGKIILAEIKALPIDPSKDLPKGYSKEEIIPDQDVMDTWATSSITPQLSALAVNSEFSLPNHRYDTIFPADLRSQSHEIIRTWAFYTILKAHYHANSLPWKNIMISGWCLADDKKKMSKSKGNIITPHIILETYGADVVRYWAANSRLGVDTVYSENTFKIGKRLVTKLWNASKFVSMFMEKHQVMSINSAHETMDKWILSKLYKVIERATNNLLQFEYCEALGAIEEFFWKDFCDSYLELVKKRAYGSSEATLSAKQSLAYVLNVILRLFAPFLPYITEEIYHQLYSYNSVHNQSNWPSKEELIYDKYSEEMGDNVIQILNIIRKIKADNNVSVKHLIKKLMIKADLRKDKLDQSAQNDLQAVCNAETIEWMQSELETEDEKYIVNIDLY
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3C_BOMMO
Sequence: MSRFFATGTDSESESSSEDEPVVRAPAPVYTFSDDEEETKRVVRSMKEKRYEELEGIIHSIRNHRKIKDFSSALASFEELQKAYTRAAPVVQKEENGVAPRFFIRALVELDDWVVGAWNEREARKALSKGNSKALTSLRQKLRKYTKDFEAEISXFREDPDLPDDNERKDSSSSDESEDEEKPIKEKPKPEPLLRPPPEDDESSDSMDWASSSSDSSFSSDDEERGTSNIREQFIKKVTKKEDDEEKIKLKLKKREERRERSGKINKRDVADDGGEWETVRKGAATSDKPKMFAKDSDIDAALVVKKLGEISAARGRKRTDRRAQLELLHELRTVALQHNLGDALQLKLRSAIVAALFDYNPKVSDAMKPEYWSKLVENIDHMVTLLLAHEDMVLSETILEENEQLVTPPYQVRGCLLTYLERLDDEFTKLLKECDPHSNEYVERLKDEVRVSALIDRVCQVVERDGTPQEICRAYLRKIDHLYYKFDPRAVRKDLPPTEETTIKKMERYCKYIYAHDETDRLRTRAILSHIYHHALHDNWFQARDLLLMSHLQETVQHSDPSTQILYNRTMANLGLCAFRRGNVKEAHGCLAELMMTGKPKELLAQGLLPQRQHERSKEQEKIEKQRQMPFHMHINLELLECVYLVSAMLIEIPYMAAHEFDARRRMISKTFYQNLRASERQALVGPPESMREHAVAAARAMRRGDWRACLNYIVNEKMNAKVWDLMVGADNVRAMLGRLIREESLRTYLFTYAHVYASLSLRSLADMFELPRQRVHSLVSKMIINEELLASLDDPSECAILHRSEPTRMQALALQLADKVGNLVDSNERIFEKQGSFFQRGGAQRGEGRQRERPREGWNRRTRNRRRDDERADD
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 subunit 8.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_STAAE
Sequence: MGNHKAALTKQVFTFASELYAYGVREVVISPGSRSTPLALAFEAHPNIKTWIHPDERSAAFFAVGLIKGSERPVAILCTSGTAAANYTPAIAESQISRIPLIVLTSDRPHELRSVGAPQAINQVNMFNNYVSYEFDMPIADDSKETIDAIYYQMQIASQYLYGPHKGPIHFNLPFRDPLTPDLNATELLTSEMKILPHYQKSIDASALRHILNKKKGLIIVGDMQHQEVDQILTYSTIYDLPILADPLSHLRKFDHPNVICTYDLLFRSGLDLNVDFVIRVGKPVISKKLNQWLKKTDAFQILVQNNDKIDVFPIAPDISYEISANDFFRSLMEDTTVNRVSWLEKWQCLEKKGRKEIKCYLEQATDESAFVGELIKKTSEKDALFISNSMPIRDVDNLLLNKNIDVYANRGANGIDGIVSTALGMAVHKRITLLIGDLSFYHDMNGLLMSKLNNIQMNIVLLNNDGGGIFSYLPQKESATDYFERLFGTPTGLDFEYTAKLYQFDFKRFNSVSEFKNATLLSETSTIYELITNREDNFKQHQILYQKLSEMIHDTL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: SYP_ZYMMO
Sequence: MRLSRYFLPVMKETPADAQIISHKLMLRAGMIRQTAAGIYAWLPLGLRVLRRIEKIIREEQARAGALELLMPTLQTADLWRESGRYDAYGPEMLRIKDRHNRELLYGPTNEEMITALIRDNLQSYRDLPRIFYHIQWKFRDEVRPRFGVMRGREFLMKDAYSFDIDETAGRHNYNRMFVAYLNSFSRLGLRAIPMQADTGPIGGDLSHEFIVLAPNGESDVFYHSNWEQPTRHIEADFDDPKALQSIVNDHISDYAATDEKRDPLREAQAGDKLRQSRGIEVGHIFFFGTKYSKPMGFTLPGPDGKPIPIQMGSYGIGISRLLGAIIEASHDDNGIIWPEAVAPYHVGLINLRIDDENCRAIADSLYQRLEAAGIDTLYDDRNERGGAKFATMDLIGLPWQVVIGPKGAEKGVVELKNRANGEKQTISVENAFNLLTAGHQQR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1177_METJA
Sequence: MRFEEFKYVRKGVIVGLLIMLLYIIWPFIDVLAYSCAFAYMALPVYNILRKKFNKTISAGLAISIYILPIMTITIYALLTFMEIILSFNTKSIEPYINEILSIYNSFMLERIINNEQIIAKYIDEFIKYLVSQFSGKIIDVGYLIVKVIMVLFLTFYFLRDGDKAKNLIISFVPDEYKEKMRIYLSYLHDSYKNLFISCVSLSIIITILSYIGYLILGVPYAELFAIITGIFALLPILGGWMVYISIAIYFFLIHDYTKAVFMFIYGELFLSIAPDFVIRPYLVKKEVDIHPVLVVIAFLMAPLSLGLSGFAIGPLVVGALNAFYLAKYRDKKI
What are the official names of this protein?
Putative transport protein MJ1177.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL36_STAAC
Sequence: MKVRPSVKPICEKCKVIKRKGKVMVICENPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: BCCP_PROFR
Sequence: MKLKVTVNGTAYDVDVDVDKSHENPMGTILFGGGTGGAPAPRAAGGAGAGKAGEGEIPAPLAGTVSKILVKEGDTVKAGQTVLVLEAMKMETEINAPTDGKVEKVLVKERDAVQGGQGLIKIG
What is the function of this protein?
The biotinyl 1. 3S subunit serves as a carboxyl carrier between the substrate-binding sites on the 12S and 5S subunits.
What are the official names of this protein?
Methylmalonyl-CoA carboxyltransferase 1.3S subunit, Biotin carboxyl carrier protein of transcarboxylase, Transcarboxylase, 1.3S subunit.
Protein: VG71_GAHVM
Sequence: MGIIFSNPIERTDKTLIESLRGRNMDLPGGGDLWIFANAGTSTMKFTTAGSRTSIQMYRVGRARTDGLTREFVILKGQDGNIYGVENASCIHFMSQNLHEFICKTGISQRDLMVTMGTFGGYKLNSPPKRYHKYHDSSLGRRRGISVDRSANTASCTQYEHEWSASGVLSTINPNDRILSHGSSKVRFGPTTVD
What are the official names of this protein?
Uncharacterized gene 71 protein.
Protein: MSHC_CORGL
Sequence: MPLELFDTADQEVRLVETPPAGSDTPVGMYVCGITPYDSTHLGHAATYLAFDLIYRILLDNDHDVHYVQNITDVDDPLFERAARDGVDWRDLGTSQINLFRSDMEALSIIPPKDYIGAIESIDEVIEMVKTLLDEGAAYIVEDAEYPDVYASINATDKFGYESNYDAATMAEFFAERGGDPERPGKKNPMDALLWRAAREGEPSWESPFGAGRPGWHIECSAIATNRLGHSFDIQGGGSDLIFPHHEFSAAHAEAAHGVERMAKHYVHAGMISQDGVKMSKSLGNLEFVSRLTAAGHEPGAIRLGVFANHYRGNRDWNAESLATAEQRLATWREAARAATNREDAIAVVEQLRAHLSADLDTPGALAAVDNWAAGIDTTTDSKEFTEVGNIVVAAIDALLGVQL
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: PSCA_HUMAN
Sequence: MAGLALQPGTALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL
What is the function of this protein?
May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.  In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.
What are the official names of this protein?
Prostate stem cell antigen.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: TRPD_SYNWW
Sequence: MFDRYLKSVVEGDYLNSEEAYLTARMLLHEDIPEIKAAAFLSALRTRKESQEELTGFVQALYEEAKMVDCGMEVLDTCGTGGDGLGTFNISTASALVVASCGVAVAKHGNRAVTGKVGSADVLEALGVEVQLEPDEARQLLDKAGITFLFAPHYHPILKQVGGLRRGLGIATIFNFMGPLLNPCRPSYQVLGISDSNLQEAVAGTLQRLGRKRALVVHAFNGMDEISPEGKTRVFDVGEHGLEVFDIDPEELGIGGFSLDAIQGGDATASARLVIKVLQGEPGPYRDTVILNTAAALLTAGRAKNIQEGMQMAAEAIDAGKSMETLQKMISFSRDRILAC
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RPOC_HYDCU
Sequence: MKDLLGFLKKQNVSSDFDTIKVTLASPEKIRSWSFGEVKKPETINYRTFKPERDGLFCAKIFGPIRDYECLCGKYKRLKHRGVICEKCGVEVTQSKVRRERMGHIDLATSVAHIWFLKSLPSRIGLMLDMTLKEIEAVLYFEAFMVVDPGLTPLEPWQLLSEEEYLDAMDEYGDEFEAQMGAEAIKKMLQAIDLDAEATRLREEMEATSSETKQKKISKRLKLIDSFVQSGNKPEWMILDVLPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLMAPDIIVRNEKRMLQESVDSMLDNGRRGRAVTGTNKRQLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPSLRLHQCGLPKKMALELFKPFIFSKLQKRGLATTIKAAKKMVEQGLPEVWDVLDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAINLHPLVCSAFNADFDGDQMAVHVPLSLEAQLEARTLMMSTNNLLSPANGDPIIVPSQDVVLGLYYITREKINAKGEGKAFSNWMEVQRALDAKAVHVHTKIKLKIEETVIDDAGVETVKKGIVDTTVGRALLLRILPKGLGFDLLNLNLTKKNISKALNACYRILGPKETVIFADQLMYAGFKWSTLAGLSFCSDDMLIPDDKAPIIERADEQVTEIQRQFAQGLVTEGERYNKVVDIWSHTNELVTKSMMEELQYETVTDAEGNEVKQTSFNSVYMMADSGARGSVAQMRQLGGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDVVVTEPDCGTDASITMAPHVEGGEVVEELKERILGRVVAEDVAGLDGEIIVEKGTLLDERLVNLIDESGVDAVKVHSPITCETKFGICQKCYGRDLARGHMVNLGEAVGVMAAQSIGEPGTQLTMRTFHIGGTASASTAQSQVEVKHEGKVKFDNLKTIKNTENQVVVTSRSGEISILDSLGREKERYKIPYGSMLNVKDGIDVTSGNVLATWDAHTHPIITEAEGIIQFGNFDGAVEEHVDELTGLTTHVVKSSKERSSATKELRPYIQLVDDKGEVVPFPGTQTPAMYYLPENSVVVVNQSDKVGAGDILARIPQESSKTKDITGGLPRVADLFEARVPKEPAIMAEVSGVVGFGKETKGKQRLVITQDSGEQHETLIPKWRSVDVFEGERVEKGDVVVDGNPNPHDILRLLGVERLTKYIVDEVQDVYRLQGVRINDKHIETVVRQMLRKVEVRSTGDTSLIKGEQAEFARVLEMNEKVSDEGSVEASYQRVLLGITKASLATESFISAASFQETTRVLTEAAVSGKEDKLVGLKENVIVGRLIPAGTGFAYHKARKEASEKTQRELAAFMNTDDESAVQEEVVEETISVTESVEQTTE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: UCSG_ACRSP
Sequence: MRNGAHRCESAMPGVTMTVLGCGKLGTAIIQGLLRSCPKASEAAPQKYLYPISTVIAAVRSKDRLESLIKSLVAEINDHTCPLDFVIANNVEAVRRADVVFLACHPNQATECLGGIGMQDAISGKLVISVLGGVSVATLEQAVYSSTRRPASGQAPCHIVQAIANTAAARQQSVTVVAEEETANSHEKGSLCEDVLRRLGQVSYVSPDLMPAVTALCASGTAFFTTYLDAMIQGAVSEGLGEDVATRLAALTMAGAANAVISGEHPAAVTSRVTTPGGVTAEGLKVLREGDLRTLTAKAISATTRRLRLVDEKSRKQS
What is the function of this protein?
Pyrroline-5-carboxylate reductase; part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that acts as a strong telomerase inhibitor and displays potent antibacterial and antitumor properties (PubMed:29373009).  These compounds share a hemiaminal-containing pyrrolizidinone core fused with a gamma-lactone, giving a furopyrrolizidine that is connected to a decalin fragment (PubMed:29373009).  The polyketide synthase module (PKS) of the PKS-NRPS ucsA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:29373009).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with a 2S,3S-methylproline derived from L-isoleucine by the 2-oxoglutarate-dependent dioxygenase ucsF which converts L-isoleucine to (4S,5S)-4-methylpyrroline-5-carboxylate that is further converted to 2S,3S-methylproline by the pyrroline-5-carboxylate reductase ucsG (PubMed:29373009).  Reductive release of the completed aminoacyl polyketide from the assembly line can form the 3-pyrrolin-2-one structure via an intramolecular Knoevenagel reaction (PubMed:29373009).  Because ucsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase ucsL (PubMed:29373009).  This keto acyclic precursor is the substrate of the Diels-Alderase ucsH, that catalyzes the Diels-Alder cycloaddition (PubMed:29373009).  Oxidation of the 3S-methyl group to a carboxylate by the cytochrome P450 monooxygenase ucsK allows an oxa-Michael cyclization that might involve the reductase/dehydrogenase ucsI and which furnishes the furopyrrolizidine (PubMed:29373009).  The oxidase ucsJ likely plays a critical role in stereoselective reduction of the C5-C6 double bond to afford the required R-configured carboxylate group (Probable).  Further enolization and oxidation at C5 by an unidentified enzyme affords the last intermediate that can undergo oxa-Michael cyclization to yield UCS1025A (Probable).
What are the official names of this protein?
Pyrroline-5-carboxylate reductase ucsG, UCS1025A pyrrolizidinone biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
Protein: VES_SHIBS
Sequence: MEYFDMRKMSVNLWRNAAGETREICTFPPAKRDFYWRASIASIAANGEFSLFPGMERIVTLLEGGEMLLESADRFNHTLKPLQPFAFAADQVVKAKLTEGQMSMDFNIMTRLDVCKAKVRIAERTFTTFGSRGGVVFVINGAWQLGDKLLTTDQGACWFDGRHTLRLLQPQGKLLFSEINWLAGHSPDQVQ
What are the official names of this protein?
Protein Ves.
What is the protein family that this protein belongs to?
Belongs to the Ves family.
Protein: RS17E_METVS
Sequence: MGRIRQTFIKRTGEELIEKFAGKFTSDFEANKKAVEEVARISTKTLRNRIAGYITAKVKKMNA
What are the official names of this protein?
30S ribosomal protein S17e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: Y2592_MYCBO
Sequence: MLFAALRDVQWRKRRLVIAIVSTGLVFAMTLVLTGLVNGFRVEAERTVDSMGVDAFVVKAGAAGPFLGSTPFAQIDLPQVARAPGVLAAAPLATAPSTIRQGTSARNVTAFGAPEHGPGMPRVSDGRAPSTPDEVAVSSTLGRNLGDDLQVGARTLRIVGIVPESTALAKIPNIFLTTEGLQQLAYNGQPTISSIGIDGMPRQLPDGYQTVNRADAVSDLMRPLKVAVDAITVVAVLLWIVAALIVGSVVYLSALERLRDFAVFKAIGVPTRSILAGLALQAVVVALLAAVVGGILSLLLAPLFPMTVVVPLSAFVALPAIATVIGLLASVAGLRRVVAIDPALAFGGP
What are the official names of this protein?
Uncharacterized ABC transporter permease Mb2592.
What is the protein family that this protein belongs to?
Belongs to the ABC-4 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KCY_LISMC
Sequence: MTKKICIAIDGPAAAGKSTVAKIVAKKLRFVYIDTGAMYRAVTYIALKNNIAYEDEKAIATLLQKTVIRFEPGEVQQVFVGEENVTEVIRSLEVTNHVSIVAAHPSIREALQERQQVFATEGGIVMDGRDIGTAVLPNAELKIFLLASVEERAERRYKENMAKGFAGDLGQLKKEIEERDHLDYTRTHSPLKKADDAIEVDTTSMSIDEVANKILSLAELKINN
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3BHS_FOWPN
Sequence: MRTLVYVVTGGCGFLGRHIINNLILFESSLKEVRVYDIRIDQWLLDLVEKCNIIKIVPVIGDVRNKSTLDEALRSADVVIHIASINDVAGKFTNDSIMDVNINGTKNVVDSCLYNGVRVLVYTSSYSAVGPNFLGDAMIRGNENTYYQSNHKEAYPLSKQLSEKYILEANGTMSNIGLRLCTCALRPLGVFGEYCPVLETLYRRSYKSRKMYKYADDKVFHSRVYAGNVAWMHILAARNMIENGQHSPLCNNVYYCYDTSPTEHYHDFNMHFFNQLGMDLRNTCLPLWCLRFIANINKGLRVLLSPICSYTPLLNPYTLIKECTTFTIETDKAFKDFGYVPLYTWEESRSKTQLWIRELEAKSSSQKPKS
What is the function of this protein?
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids.  The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity).
What are the official names of this protein?
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase, 3-beta-HSD.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.