PharMolix/UniProtQA huggingface dataset:
Protein: ENGB_EHRCJ
Sequence: MKLKAIMSKCEFIIGATHVKSFPNFSIPEIAIAGRSNVGKSSLINAITNNKKNAKTSSRPGCTKQINFYLINKSFMVLVDLPGYGYSKATRATINNYLFLMEYYLLNSKNLLKVILLIDVKVGFKEIDLDFINWLELNHIYYQLVLTKIDRVSKEILDVNINYIKNLNLGFVIYPVISASSKYKQGIGELIYEIAQCIKK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: GSXL5_ARATH
Sequence: MAPALSPTRSHHVAVIGAGPAGLVAARELRREGHSVVVFEKQKQVGGTWIYTDEVESDPLSVDPTRSVVHSSVYRSLRINGTRECTGYRDFPFVVRSGVSRDRRRFPSHGEVLAYLKDFAKEFGIEEMVRFETEVVKVSPAAEEGIGKWRIESTEKEKKVRRDEIYDAVVVCNGHYVEPRLAQIPGISSWPGKEMHSHNYRIPEPFRDKVAVLIGNSSSAEDISRDIARVAKEVHVACRSNPADTFIKQTGYNNLWTHSMIESVHEDGSVVYQNGKTISVDIIMHCTGYKYHFPFLDTNGIVTVDDNRVGPLYKDVFPPAFAPWLSFIGIPWQVLPFPMFELQSKWIAGVLSGRIPLPSKEDMMIEIKTFYSTLEVQGIPKRYTHRMGNTQFEYDNWLASQCGCSETEEWRKEMCLANGVRKEAHPETYRDEWDDHHLVSEAYQDFSLYS
What is the function of this protein?
Catalyzes the conversion of methylthioalkyl glucosinolates of any chain length into methylsulfinylalkyl glucosinolates.
What are the official names of this protein?
Flavin-containing monooxygenase FMO GS-OX-like 5, Flavin-monooxygenase glucosinolate S-oxygenase-like 5.
What is the protein family that this protein belongs to?
Belongs to the FMO family.
Protein: PYRH_MYCTA
Sequence: MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_CAMJ8
Sequence: MKKEIHPEYVECKVSCACGNTFTTKSNKAELRVDICSNCHPFFTGSEKIVDAAGRVEKFKKKYAMQ
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: 5DNU_SALDC
Sequence: MKQSHFFAHLSRMKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGQLNAERIALLAMYHDASEVLTGDLPTPVKYFNSQIAQEYKAIEKIAQQKLVDMAPDELRDIFAPLIDENAWSEEEQAIVKQADALCAYLKCLEELSAGNNEFGLAKTRLEKTLELRRSQEMDYFMAVFVPSFHLSLDEISQDSPL
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase YfbR, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_HALH5
Sequence: MKRIGLKVAYDGTDFAGYQIQPNERTVQGELESVLKNIHKGMSIRVTASGRTDTGVHARGQIVHFDTSLSFPVDRWPIALNSQLPADICVLEAADVPADFHARYSAKTKEYRYRVLTSAQADVFRRNYTYHVRYPLDVEAMQRAAVQLLGTHDFSSFCAAKAEVEDKVRTIEDVALWREGDELIFSIRGNGFLYNMVRIIVGTLLEIGAGKRSAEEVAKILAARSREAAGKTAPGHGLISGRSNMTNGKLENNKTTNPCVTKY
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: HFLD_AERHH
Sequence: MSDKFQDRTMAFAGICQAAYLVQKVARDGSCDEAALRESLSSILVTNPSQPLEVFNNTHLAIRDGYRALVEQLGADGSQKNAELTRYVVSLIALERKLAKRKDILNMLGERISQIGRQQQHFDLLDEQILANMASIYSDLISPIGPRIQVAGTPLFLQQPLVQHKVRALLLAGIRACVLWRQLGGSRTQIIFARKKMVELAKRY
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GCH1_CAMJ8
Sequence: MQKKFEDCVKTILEIIGENPNREGLIKTPNRVFKAYEFLTSGYTQNVKEILNDALFESSNNEMVLVRDIEFYSLCEHHLLPFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLTEQIAQALMENVDAKGVGVVIEARHMCVEMRGVQKANSTTTTSALRGIFLKNEKTREEFFSLINSAKQVRF
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: YGFZ_ECODH
Sequence: MAFTPFPPRQPTASARLPLTLMTLDDWALATITGADSEKYMQGQVTADVSQMAEDQHLLAAHCDAKGKMWSNLRLFRDGDGFAWIERRSVREPQLTELKKYAVFSKVTIAPDDERVLLGVAGFQARAALANLFSELPSKEKQVVKEGATTLLWFEHPAERFLIVTDEATANMLTDKLRGEAELNNSQQWLALNIEAGFPVIDAANSGQFIPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALWLLAGSASRLPEAGEDLELKMGENWRRTGTVLAAVKLEDGQVVVQVVMNNDMEPDSIFRVRDDANTLHIEPLPYSLEE
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2048_ARCFU
Sequence: MAKQMEKKSARLLAFLLALIMIGSVFAYMLSGGSAEHREVVYRLDDFREYVNWTPADPVYVQYYNLSYTSKLGSKDPLASMVTTDLQKLLIPAIFSRQVLEVTRGISQVMIVDFGETVPLYFVDAGMSKIYFAKEDEIKHGNFTLQVRRPGIALVSELSPLVVGYKPLVEKAVDTVEGNYPSFGNKTYSYLSRINGSFAYAFFAYGDVVKQWIRVGNESPADFFFEGYRYNFNNSSYEKVWAMHFEGNYFFGGMNESEKNFEYYKVQNFGDGLSVAVMEDKNFTKVVNARPNILTWQISFNNTQNES
What are the official names of this protein?
Uncharacterized protein AF_2048.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TARA_STAAM
Sequence: MTVEERSNTAKVDILGVDFDNTTMLQMVENIKTFFANQSTNNLFIVTANPEIVNYATTHQAYLELINQASYIVADGTGVVKASHRLKQPLAHRIPGIELMDECLKIAHVNHQKVFLLGATNEVVEAAQYALQQRYPNISFAHHHGYIDLEDETVVKRIKLFKPDYIFVGMGFPKQEEWIMTHENQFESTVMMGVGGSLEVFAGAKKRAPYIFRKLNIEWIYRALIDWKRIGRLKSIPIFMYKIAKAKRKIKKAK
What is the function of this protein?
Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.
What are the official names of this protein?
N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase, N-acetylmannosaminyltransferase, UDP-N-acetylmannosamine transferase, UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
Protein: TRMA_YERPS
Sequence: MTPNILPIESYDHQLAEKSARLKAMMLPFQAPEPEIFRSPADHYRMRAEFRVWHDEDDLYHIMFDQQTKQRIRVEQFPVASRLINRLMDALMTAIRAEPLLRRKLFQIDYLSTLSGKLIASLLYHRQLDEEWQQKALELRDQLRAQGFDLQLIGRAAKTKIMLDHDYIDEVLPVAGREMIYRQVENSFTQPNAAVNIHMLEWALDVTQGATGDLLELYCGNGNFSLALARNFERVLATEIAKPSVAAAQYNIAANNIDNVQIIRMSAEEFTQAMQGVREFNRLKGIDLGSYNCETIFVDPPRSGLDHETVKLVQAYPRILYISCNPETLCANLEQLQHTHKISRLALFDQFPYTHHMECGVLLEKRH
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: DFA4_SYNY3
Sequence: MISPIGGLSQALHSPSDSIFVASLPRDIQVAEIAPQTKVLRSRLWDRLKFEVEYGRRRGTTSNSYLIQADHTALIDPPGESFCDLYLAELPKYLDLAQLDYIVASHVNPNRMVTLEQLLRRATKAKLICSRPAAKVLKATFPHWEERFQTVRSQDMLDLGRGHKLQLMTLPTPRWPDGLCAYDAGSQILFSDKLFGTHVCGDAIFDEDWRQLGGDRRFYFDCLHAPQTRQVETALDQFDPLTLKMIAPGHGPLVRFSLSRLYSDYRQWCQQQPSQTLKVALIYASAYGNTATMARAIAQGLVKAGVAVETINCEIAEPNEIVEAIQACDGFIVGSPTLGSHAPVQIQTALGIVLSSATKTKLAGVFGSYGWSGEAIDLIENKLKDGGYRFGFEAIRIQFSPNLDALDVCTTSGANFARQLRTHKRQRIARQATTETQADRTQQAVGRIIGSIGVVTTQTTGRHQGILTSWVSQASFTPPGIMLAIPGEFDAYGLAGQNKAFVLNLLQEGRSVRRHFDHQPLPKDGDNPFSRLEHYSTQNGCLILAEALAYLECLVQSWSNIGDHVLVYATVQAGQVLQPNGITAIRHRKSGGQY
What is the function of this protein?
Mediates electron transfer from NADH to oxygen, reducing it to water.  This modular protein has 3 redox cofactors, in other organisms the same activity requires 2 or 3 proteins (By similarity).
What are the official names of this protein?
Putative diflavin flavoprotein A 4.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavodoxin reductase family.
Protein: PSN1_HUMAN
Sequence: MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
What is the function of this protein?
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874, PubMed:28269784, PubMed:20460383).  Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874).  Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883).  Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314).  Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314).  This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:9738936, PubMed:11953314).  Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity).  Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784).  The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:25394380, PubMed:16959576).  Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383).  Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity.  It acts through the control of SYT7 presynaptic expression (By similarity).
What are the official names of this protein?
Presenilin-1, PS-1, Protein S182.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
Protein: GUAC_OCEIH
Sequence: MENVFDYEDIQLIPAKCVVNSRSECDTSVTLGNRTFKLPVVPANMQTIIDEKIAKYLAEKNYFYIMHRFEPEKRIDFIQDMQEYNLFTSISVGVKEEEYTFIEDLAAKQLIPDYITIDIAHGHSDAVIKMIKHIKNNLPSSFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHEESPGETIEQDGKKIKEYFGSASEFQKGEKKNVEGKKMYVEHKGPLQDTLTEMEQDLQSSISYAGGKQLDAIRNVDYVVVKNSIFNGDKVF
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: RNPA_HISS2
Sequence: MVKLGFSRELRLLTPSHFKCVFQKPLRVSTPEITILARKNNLEHSRLGLTVAKKHLKRAHDRNRVKRISRESFRLLQGQLANYDFVIITKKGIGNLDNQQLFQTLDKLWKRHIRLVQKS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: ZIPA_ECODH
Sequence: MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDEDVEDDEGVGEVRVHRVNHAPANAQEHEAARPSPQHQYQPPYASAQPRQPVQQPPEAQVPPQHAPHPAQPVQQPAYQPQPEQPLQQPVSPQVAPAPQPVHSAPQPAQQAFQPAEPVAAPQPEPVAEPAPVMDKPKRKEAVIIMNVAAHHGSELNGELLLNSIQQAGFIFGDMNIYHRHLSPDGSGPALFSLANMVKPGTFDPEMKDFTTPGVTIFMQVPSYGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDIIREVKDANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: MI1HG_HUMAN
Sequence: MPSCSCALMAPCGPAAGPAAVERTQQVARGEPGSARGQLQVSPEMSITHKEKENAHLKEILLFVNAEAFSQPQPHSAPVCEGQQLTGKFSTSVLTRAGGDASPCSWERLLCYGWSHC
What are the official names of this protein?
Uncharacterized protein MIR1-1HG, MIR1-1 host gene protein.
Protein: Y1918_VIBC1
Sequence: MSELKQKQVFKEKVMHSEEEDVSPELNTQKTFSEKETFIPVEIEEQQKETEQELQLEQVIRPKSGRKWLTTGLFATFAGLVVWQAVDSVITAIQTADWLALGWVGFITTIASFGLGALGKELWKLRKLRNHFSVQEESEALIDSQSVGKGKAFCEKVAEQSGVLAENPGFDRWKNSVNPAHSDAEILEMYDSMVVSQQDKLATKIVSQHATESAALVAVSPLAAADMLLVAWRNFKMIDNLSKVYGVELGYASRIKLLRSVFVNMAAAGASELAIDASMDLMSMDLAGKISARAGQGLGVGILTARLGLKSMALLRPLPWYPERQVKLGAIRKEVVAKVASITMKP
What are the official names of this protein?
UPF0283 membrane protein VIBHAR_01918.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBC2_YARLI
Sequence: MSTTARRRLMRDFKRMQQDPPQGVSASPVADNVLTWNAVIIGPAETPFEDGTFRMVLQFDEQYPNKPPAVKFVSQMFHPNVYSSGELCLDILQNRWSPTYDVAAILTSVQSLLNDPNTSSPANVEASMLYKDHRQQYEKRVRDTVEASWTD
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.  Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 2, E2 ubiquitin-conjugating enzyme 2, Ubiquitin carrier protein UBC2, Ubiquitin-protein ligase UBC2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ILIE_NEOS2
Sequence: MSEQLGSHITTPSSHDDASKDKRPAAEVVNGSGIFIMADLHTGKPITLKCGLTLPNRLVKAATAESMAPNNTLPDEKFQNLYRHWAEGGWGMVLAGNVQVDANHICTATDLSVDHSLSDSKIVEAWRPWAAACNGNGTVTVMQLCHPGRQSPAGAGKRGLFAKSIAPSAVALQMGSGLVAKAVTALLFGTPREMSVSDIETVVSQFARSARLAAESGFAGVEVHAGHGFLLEQFLSTKSNRRTDAYGGTPAKRARIVVEVLTAIRAVVPAGFCVGLSLNSVDLQSQTELKDCVEQVKLITDAGVDFIEVSGGTFENPTMFLGPEKSRKQAQLGQPLAHEPFFLDFAKAIRPHVPGVPLIVTGGFRSCQGIEETIAGGDADLVGLARPAVVNPLLPKTTVLSPKTTEFGPEIEDGDVTLYAKKTEAPWILKQIGIRAVEVHIDNSVYHNRRHAAKQVRRASVLLQFPSRPSLSVAAVDIDNVISRLSTARPFVFIFLAITVEVNIDTDIAALLLALRPSPELYHLAAAMPPRRSDGSADHDVPDWPKTPHPTPYDILAMRKDDPYTKHRFFQLVKIYHPDRHGHTPAVHRLPHATRLERYRLIVAANDLLSNPSKRSLYDTQGVGWTGDRPPTLNESVRHAEKSWRHQPGNASRNATWEDWERWYDARDGKTRDPMYMSNGVFATLVVMMCMIGAFAQMSRAEQSGTEYLETRDQSNLAIGQQISRTTLVSAGRSKDERVDSFLRERENVAYEFTPSKYDDRTRTEA
What is the function of this protein?
NADH-dependent flavin oxidoreductase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:31216742).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (PubMed:31216742) (Probable).
What are the official names of this protein?
NADH-dependent flavin oxidoreductase iliE, Epimerase iliE, Ilicicolin H biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: WNT1_AMBME
Sequence: MRPMTFIVGLKTLWILAFSSLSNTLAVNNSGRWWGVVNVVTSTNLLTDTKNVQLVLDPSLQLLSRKQRKLIRQNPGILHSINSGLQSAMKECKWQFRSRRWNCPTTGGDNIFGKIVNKGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGTDWHWGGCSDNIDFGRVFGREFVDSSERGRDLRYLMNRHNNEAGRMTVFSEMKQECKCHGMSGSCAVRTCWMRLPTFRAVGDFLKDRFDGASRVIYGNKGSNRASRVQTHHLEPENPTHKPPSPQDLVYFEKSPNFCTYNGKTGTSGTSGRVCNSSSLGLDGCELLCCGRGYRTKTQRVTERCHCTFHWCCHVSCLNCTNTQVLHECL
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity).  Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity).  Has a role in osteoblast function, bone development and bone homeostasis (By similarity).
What are the official names of this protein?
Protein Wnt-1.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: VG19_BPML5
Sequence: MAYATAEDVVTLWAKEPEPEVMALIERRLQQIERMIKRRIPDLDVKAAASATFRADLIDIEADAVLRLVRNPEGYLSETDGAYTYQLQADLSQGKLTILDEEWEILGVNSQKRMAVIVPNVVMPT
What are the official names of this protein?
Gene 19 protein, Gp19.
Protein: Y2317_MYCBO
Sequence: MPVEETSTPQKLPQFRYHPDPVGTGSIVADEVSCVSCEQRRPYTYTGPVYAEEELNEAICPWCIADGSAASRFDATFTDAMWAVPDDVPEDVTEEVLCRTPGFTGWLQEEWLHHCGDAAAFLGPVGASEVADLPDALDALRNEYRGYDWPADKIEEFILTLDRNGLATAYLFRCLSCGVHLAYADFA
What are the official names of this protein?
UPF0167 protein Mb2317.
What is the protein family that this protein belongs to?
Belongs to the UPF0167 family.
Protein: YGFZ_SALPA
Sequence: MAFISFPPRHPSSSARLPLTLIALDDWALSTITGVDSEKYIQGQVTADVSQMTEQQHLLAAHCDAKGKMWSTLRLFRERDGFAWIERRSVREAQLTELKKYAVFSKVVIAPDDERVLLGVAGFQARAALANVFSELPNSENQVVRDGASTLLWFEHPAERFLLVTDVATANMLTEKLHGEAELNNSQQWLALDIEAGIPVIDAANSGQFIPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALWLLAGKASRVPEAGEDLELQMGENWRRTGAILAATQLDDGQLLVQAVMNNDLEAESVFRVRDDANTLHIVPLPYSLEE
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITAV_CHICK
Sequence: MAALRASLLLSCALTAARAFNLDAERPAVYSGAEGSYFGFAVDFFAPDASSMFLLVGAPKANTSQSNVVEGGQVLQCNWNSNRNCQPIIFDSTGNRDFAPDDPLEFKSHQWFGASVRSKNDKILACAPLYHWRTETKQEREPVGTCYLFDGSKSVEYAPCRSTTIDADGQGFCQGGFSIDFTKGDRVLLGGPGSFYWQGQLISDRVAEILAKYDSKVYSTKYDDQLATRPASAAFDDSYLGYSVAVGDFSGDGIEDFVSGVPRAARTLGMVSIYNGKNMSSMYNFTGEQMAAYFGYSVATTDINGDDYTDLFIGAPLFMDRGSDGKLQEVGQVSICLQRASGGFQIAKLNGFEIFARFGSAIAPLGDLDQDGFNDIAVAAPYGGEDKRGLVYIYNGRATGLNAVPSRILEGQWAARTMPPSFGYSLKGATDVDKNGYPDLIVGAFGVDTAVLYRARPVIRVNAALEVNPTILNPENKACSLADVKVSCFKVKFCLKADGKGKLPNSLNFQVELLLDKLKQKGAIRRALFLHSKQPSHSKNMTITKGGKMNCEELDAFLRDESEFRDKLTPITIFMEYRLDYKTAVDATGLHPILNQFIPANMSRQAHILLDCGEDNICKPKLEVSVRSDQKKIYIGDDNPLTLIVTAENQGEGAYEAELFVIVPPQADFIGVVRNNEALARLSCAFKTENQTRMVVCDLGNPMKAGTKLLAGLRFSVHQQSEMDTSVKFDLQIRSSNLFDNLSPVAFYQVDLAISAAVEIRGVSSPDHIFLPIANWQPKENPETEDDIGPLVQHIYELRNNGPSAFSKVMMTLQWPYKYKNYTLLYIVQYDIDGPMNCTSDMEINPLKIKISAPKEDEKNETFSREDNRNHRISRRDLTAIEGDVQTLGCGNADCLKIVCQVGHLERGKSAILYLKSRLWTQTFMNKENQNHSYSLQSSASFNVIEFPYKNLSFEDIHNSTVVTTNITWGIQPQPMPVPVWVIILAVLAGLLLLAVLVLVMYRMGFFKRVRPPQEEQEREQLQPHENGEGTSEA
What is the function of this protein?
The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF.  They recognize the sequence R-G-D in a wide array of ligands.  Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity).  ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling.  ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling.  ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling.  ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling.  ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling.  ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.  ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling.  ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.  ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity).  Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).  ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity).
What are the official names of this protein?
Integrin alpha-V, Vitronectin receptor subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.