PharMolix/UniProtQA huggingface dataset:
Protein: RT106_KLULA
Sequence: MPNFLEKLSESLREKVLHIVSKEPDSISIFQEVYNCGKDSQDEDIDNKKRKLTTTDTLSVNDENVVFELQDVSVLSPLRKKLTVLIAVDERDQSPMISFNKNNNVEYVINNIKQSVKFSTFLPFPEKKNLVYLYMNYERDGSNADPVLITLNKEQILKQFKERNLLKAEDSDFQLCVDYMRRQAILTGFRISDPFSKSVMDSHHSFFVDCHRGSKEGTLFFLPEHIIFGFKKPILLFESKQIDAITYSSITRLTFNVTLITKDGERFEFSMIDQNKFSEIDEYVKKKQVEDKSMSDELKAKTPKSGQTSDQSALKEALEESGTLDTMNGESDDEDDQNFEEESDLSDGSGSGDDDEDDDDDDDDEDDDSIEKGDDGEEEEDDNEEEEQEEEEKEEQEQEQNRQILNRASPNAAPSNHFSMEIDEIPDLLDENGLIQDIPITMDDDNDEEEEEGSGVEYD
What is the function of this protein?
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing.  Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA.  Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
What are the official names of this protein?
Histone chaperone RTT106.
What is the protein family that this protein belongs to?
Belongs to the RTT106 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: IPKB_HUMAN
Sequence: MRTDSSKMTDVESGVANFASSARAGRRNALPDIQSSAATDGTSDLPLKLEALSVKEDAKEKDEKTTQDQLEKPQNEEK
What is the function of this protein?
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
What are the official names of this protein?
cAMP-dependent protein kinase inhibitor beta, PKI-beta.
What is the protein family that this protein belongs to?
Belongs to the PKI family.
Protein: RIMO_TRIEI
Sequence: MSTKPTIAFTHLGCEKNRIDTEHIIGLLVQAGYEVDANEELADYVVVNTCSFIQAAREESVKTLVELAEANKKIVIAGCMAQHFPEELLAELPEAIALVGTGDYHKIVDVMQRVEKGDRVKEVTAEPTYIADETTPRYRTTSEGVAYVRIAEGCDYRCAFCIIPHLRGKARSRTIESIVVEAQKLADQGVKEIILISQITTNYGIDIYGQPKLADLLEALGKVDIPWIRMHYAYPTGLTPKVITAIQDTPNILPYLDLPLQHSHPEILRAMNRPWQGQVNDDIIKRIKTAMPNAVLRTSFIVGFPGETEEHHSHLVEFVKRHEFDHVGVFTFSPEEGTPAYNLPNQLPQEVMDARRQEIMEVQQSISWQQNQKLVGQLVDVLIEQENPQTGELIGRSPRFSPEVDGLIYVKGEARLGCIVPVMITDADIYDLYGCLISSAA
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYAL_CONPU
Sequence: MRVVVVVTGLVVVVVATALSLPDHDVKSASSPLSSSSVYQGSSGDDCDEGLPPPDRPFYVVWNHPDTCKRNRIPLHLDHYGFIFNKNRLFLGEEIQTLYNTGLWPNISETGEFFNGGLPQLFTHHDYSETVEILGRYRTENFTGLGILDFEEWRAIYDTNFGIMRKYQDESIKLAKQRYPSYNKKELTMVAEQEWDQAAREIMSTKLAIGQALMPGGHWGYYGYPRTWGSKRNTQLRNNRIDWLWRQSTGLYPSIYIKDPNMTESAIAEFVSGNVEEAVRVQDEFSPPNTPIYPYAMLQSGDHIFFQVDHLKISLGLPAKMGTSGVILWASSNRYKNATRQCSRMRVHIDNVLGPYVENLTQVMADCSTTLCGGHGRCVHNSHDVLLGETDSQRLSGLCTPRHSRFRDYHCRCYSDWEGACCQTVRPSRCHKQQQGNVHEGGDLQEGHVVNVVNPLIG
What is the function of this protein?
Hyaluronidase catalyzes the hydrolysis of hyaluronic acid (HA), an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues (PubMed:28479398).  In venom, they are known to enhance diffusion of the venom by degrading the extracellular matrix (Probable).
What are the official names of this protein?
Hyaluronidase conohyal-P1, Hyaluronoglucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DJC12_BOVIN
Sequence: MDAILNYKSEDTEDYYTLLGCDELSSVEQILAEFKVRALECHPDKHPENSKAVETFQKLQKAKDILTNEASRARYDHWRRSQMSMSFQQWEALSDSVKMSMHWAVRGKKDLMLEESDQTPTDKIENEEQDEQKEIKKEEFGSTTEKMEQKESKSVEKSFSPQNPDSPGFANVNCWHLRFRWSGDAPSELLRKFRNYEI
What are the official names of this protein?
DnaJ homolog subfamily C member 12, J domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPMA_SHIB3
Sequence: MSETASWQPSASIPNLLKRAAIMAEIRRFFADRGVLEVETPCMSQATVTDIHLVPFETRFVGPGHSQGMNLWLMTSPEYHMKRLLVAGCGPVFQLCRSFRNEEMGRYHNPEFTMLEWYRPHYDMYRLMNEVDDLLQQVLDCPAAESLSYQQAFLRYLEIDPLSADKTQLREVAAKLDLSNVADTEEDRDTLLQLLFTFGVEPNIGKEKPTFVYHFPASQASLAQISTEDHRVAERFEVYYKGIELANGFHELTDAREQQQRFEQDNRKRAARGLPQHPIDQNLIEALKVGMPDCSGVALGVDRLVMLALGAETLAEVIAFSVDRA
What is the function of this protein?
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'.  Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34'.
What are the official names of this protein?
Elongation factor P--(R)-beta-lysine ligase, EF-P--(R)-beta-lysine ligase, EF-P post-translational modification enzyme A, EF-P-lysine lysyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
Protein: S2512_HUMAN
Sequence: MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVVQPKAAVAATQ
What is the function of this protein?
Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575).  Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton.  Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871).
What are the official names of this protein?
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial, Araceli hiperlarga, Aralar, Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RU2A_HUMAN
Sequence: MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIARRSKTFNPGAGLPTDKKKGGPSPGDVEAIKNAIANASTLAEVERLKGLLQSGQIPGRERRSGPTDDGEEEMEEDTVTNGS
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:27035939).  Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128, PubMed:27035939).
What are the official names of this protein?
U2 small nuclear ribonucleoprotein A', U2 snRNP A'.
What is the protein family that this protein belongs to?
Belongs to the U2 small nuclear ribonucleoprotein A family.
Protein: RS17_MESM1
Sequence: MQERINRRKALTGVVVSDKSSKTIVVAVDTFKKDPLYQKRFKSTKKFAAHDEKEEAQMGDIVKIVGTRPLSKTKFFRLEKIRQRAKEGKGSE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: FADB_SHEB8
Sequence: MIYQSPTIQVELLEDNIAKLCFNAPGSVNKFDRETLASLDAALDSIKQDSNIKALVLTSSKDTFIVGADITEFLGLFAQDDAVLLSWVEQANAVFNKLEDLPFPTASAIKGFALGGGCETILATDFRIADTTAKIGLPETKLGIIPGFGGTVRLPRVIGADNALEWITTGKDQRAEDALKVGAVDSVVAPQALEAAAIQMLKDAVAEKLDWQARRNRKLSALTLPKLEAMMSFTTAKGMVFAVAGKHYPAPMAAVSVIEQASTKGRAEALQIEHQAFIKLAKTDVAKALIGIFLNDQFVKGKAKKAGKLAKEVNNAAVLGAGIMGGGIAYQSASKGTPIVMKDIAQPALDLGLNEAAKLLSAQVARGRSTPEKMAKVLNNITPSLDYAAIKHSDVVVEAVVEHPKIKAQVLAEVEGYVSEDAIIASNTSTISINLLAKSMKKPERFCGMHFFNPVHKMPLVEVIRGEHSSEETIASVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAGFNGLLAEGGDFAAIDKVMEKQFGWPMGPAYLLDVVGLDTGHHAQAVMAEGFPDRMGKSGTDAIDVMFENKRLGQKNGKGFYVYSVDSRGKPKKDVDPTSYGLLKDAFGELKAFEADDIIARTMIPMIIETVRCLEEGIVASPAEADMGLVYGLGFPPFRGGVFRYLDTMGVANFVALADKYAHLGGLYQVTDAMRTLAANNGSYYQA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: AMYG_SACFI
Sequence: MKFGVLFSVFAAIVSALPLQEGPLNKRAYPSFEAYSNYKVDRTDLETFLDKQKEVSLYYLLQNIAYPEGQFNNGVPGTVIASPSTSNPDYYYQWTRDSAITFLTVLSELEDNNFNTTLAKAVEYYINTSYNLQRTSNPSGSFDDENHKGLGEPKFNTDGSAYTGAWGRPQNDGPALRAYAISRYLNDVNSLNEGKLVLTDSGDINFSSTEDIYKNIIKPDLEYVIGYWDSTGFDLWEENQGRHFFTSLVQQKALAYAVDIAKSFDDGDFANTLSSTASTLESYLSGSDGGFVNTDVNHIVENPDLLQQNSRQGLDSATYIGPLLTHDIGESSSTPFDVDNEYVLQSYYLLLEDNKDRYSVNSAYSAGAAIGRYPEDVYNGDGSSEGNPWFLATAYAAQVPYKLAYDAKSASNDITINKINYDFFNKYIVDLSTINSAYQSSDSVTIKSGSDEFNTVADNLVTFGDSFLQVILDHINDDGSLNEQLNRYTGYSTGAYSLTWSSGALLEAIRLRNKVKALA
What are the official names of this protein?
Glucoamylase GLU1, 1,4-alpha-D-glucan glucohydrolase, Glucan 1,4-alpha-glucosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 15 family.
Protein: ZN528_HUMAN
Sequence: MALTQGPLKFMDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLGICLPDLSVTSMLEQKRDPWTLQSEEKIANDPDGRECIKGVNTERSSKLGSNAGNKPCKNQLGFTFQLHLSDLQLFQAERKISGCKHFEKPVSDNSSVSPLEKISSSVKSHLLNKYRNNFDHAPLLPQEQKAHIREKAYKCNEHGQVFRASASLTNQVIHNADNPYKCSECGKVFSCSSKLVIHRRMHTGEKPYKCHECGKLFSSNSNLSQHQRIHTGEKPYKCHECDKVFRSSSKLAQHQRIHTGEKPYKCHECDKVFNQIAHLVRHQKIHTGEKPYSCNKCGKVFSRHSYLAEHQTVHTGEKPYKCEECGKAFSVRSSLITHQLIHTGRKPYKCKECDKVFGRKCFLTSHQRIHTRERPYGCSQCGKIFSQKSDLIRHRKTHTDEKPYKCNKCGTAFREFSDLTAHFLIHSGEKPYECKECGKVFRYKSSLTSHHRIHTGEKPYKCNRCGKVFSRSSNLVCHQKIHTGEKPYKCNQCGKVFNQASYLTRHQIIHTGERPYRCSKCGKAFRGCSGLTAHLAIHTEKKSHECKECGKIFTQKSSLTNHHRIHIGEKPYKCTLCSKVFSHNSDLAQHQRVHS
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 528.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARLY_HELMO
Sequence: MSKKLWGGRFEKGTDKVVEDFHSSIRFDQRLYKQDIRGSIAHARMLGRQGIIAASEAEQIIEGLEKIMADIEAGRVEFDVAAEDIHMNIEKILTERIGDVGKKLHTGRSRNDQVALDVRLYLRDEITETGRLLRELITVLLERAEEHVDTIMPGYTHLQKAQPITLAHHLLAYVQMFGRDCSRLVDCAKRFNISPLGSGALAGTTFPLDRMAVAQELGFDGITENSLDGVSDRDFAIEFCGAASLIMMHLSRFCEEIILWSSQEFSFIELDDAYSTGSSMMPQKKNPDVAELIRGKTGRVYGDLMALLTVMKSLPLAYNKDMQEDKENLFDAVDTVKGCLAVFTPMIRTMRVRGERMKAGAKGGFTNATDVADYLAKKGVSFREAHEIVGKMVLMCVQKSVALEDLSFEDFRACSEAFEEDVFDAIRVERCVADRKVPGGPAPDAVKAAIQAARERLS
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUA5_GORGO
Sequence: MAGVLKKTTGLVGLAVCNTPHERLRILYTKILDVLEEIPKNAAYRKYTEQITNEKLAMVKAEPDVKKLEDQLQGGQLEEVILQAEHELNLARKMREWKLWEPLVEEPPADQWKWPI
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5, Complex I subunit B13, Complex I-13kD-B, CI-13kD-B, NADH-ubiquinone oxidoreductase 13 kDa-B subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA5 subunit family.
Protein: EMC1_CHICK
Sequence: MAAGLWALLLPLAAAVYEDQVGKFDWRQQYVGKLKFASLEAAQGSKKLLVGTEKNVVAALNSRSGEILWRHADKATPEGAIDAMLIHGQDAITVSSAGRILRSWETNIGGLNWETSLDTGSFQTASLVGLQDAVKYVAVLKKAAISLHYLSNGHQKWVEHLPESENTQYQMLYSRGAGVIHVLGVVPQSHLKVLTLSVEDGEVIEQTKVAAPWLKSLNGACGVVGEAVLVCADTATHSLYVCSLETEQEMKQIPLQSLDLEFADGFQPRVLATQPSVINASRTQFFLQLSPGHFSLLQCKQGLLSHLRDFQQAALVSFATTGEKTVAAVLTCRNELKPASSDGLHGNALEDSQKQEALTCSNQTYNINLYLVETGQRLLDTTITFNLEQNGAKPEQLYIQVFLKKDDSVGYRALVQTEDHMLMFLQQPGKVVWSREESLAEVVSLEMVDLPLTGAQAELEGEFGKKADGLLGMFLKRLSSQLILLQAWTAHLWKMFYDARKPRSQIKNEINIDNLARDEFNLQKMMVMVTASGKLFGIESSSGTILWKQYLRNVRPGASLKLMVQRTTAHFPHPPQCTLLVKDKETKMSFLYVFNPIFGKRSQVAPPVLKRPVLQTLLLPIMDQDYAKVLLLIDDEYKVTAFPATKNVLRQLEEMAHSIFFYLVDAEQGKLSGFRLKKDLTTEESWQVAIPTEVQRIVTVKGKRSSEHVHSQGRVMGDRSVLYKSLNPNLLAVVTESTDTHHERTFVGIYLIDGVTGRIIHSSVQKKAKGPVHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQYNATAFSSLDRPLLPQVLQQSYIFPSAISAMEATITERGITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERFINYNQTVSQIRGIYTSPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGLVFATMITKRLAQVKLLNRAWR
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the EMC1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: ADAM2_MOUSE
Sequence: MWLILLLLSGLSELGGLSQSQTEGTREKLHVQVTVPEKIRSVTSNGYETQVTYNLKIEGKTYTLDLMQKPFLPPNFRVYSYDNAGIMRSLEQKFQNICYFQGYIEGYPNSMVIVSTCTGLRGFLQFGNVSYGIEPLESSSGFEHVIYQVEPEKGGALLYAEKDIDLRDSQYKIRSIKPQRIVSHYLEIHIVVEKQMFEHIGADTAIVTQKIFQLIGLANAIFAPFNLTVILSSLEFWMDENKILTTGDANKLLYRFLKWKQSYLVLRPHDMAFLLVYRNTTDYVGATYQGKMCDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGLAYDDVNKCQCGVPVCVMNPEAPHSSGVRAFSNCSMEDFSKFITSQSSHCLQNQPRLQPSYKMAVCGNGEVEEDEICDCGKKGCAEMPPPCCNPDTCKLSDGSECSSGICCNSCKLKRKGEVCRLAQDECDVTEYCNGTSEVCEDFFVQNGHPCDNRKWICINGTCQSGEQQCQDLFGIDAGFGSSECFWELNSKSDISGSCGISAGGYKECPPNDRMCGKIICKYQSENILKLRSATVIYANISGHVCVSLEYPQGHNESQKMWVRDGTVCGSNKVCQNQKCVADTFLGYDCNLEKCNHHGVCNNKKNCHCDPTYLPPDCKRMKDSYPGGSIDSGNKERAEPIPVRPYIASAYRSKSPRWPFFLIIPFYVVILVLIGMLVKVYSQRMKWRMDDFSSEEQFESESESKD
What is the function of this protein?
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.  Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct.  Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg.  This is a non catalytic metalloprotease-like protein (By similarity).
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 2, ADAM 2, Fertilin subunit beta, PH-30, PH30, PH30-beta.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: LRL14_ARATH
Sequence: MYYPLSSSLMFFILFSLFYHLPCESSKCESLFQCGNITASFPFWGGDRHKHCGHPLLELRCDQNKSTSLFISDQEFFVLHVDQTSYSLTLARPDLLHSFCSLTFTNTTLPPEIFELSPAYKSVTFYHCYPVLPDLSNYTCPVIGPISVSGNPEDHETCFPNFAANVPTSFVTKEKKLNIANLESVLEKGFEVNMNVIMKACQACSYSNESCGFDENFPFEVKCKPHHSPTDTSLSIGAKAGIAVASVSGLAILLLAGLFLCIRRRRKTQDAQYTSKSLPITSYSSRDTSRNPTSTTISSSSNHSLLPSISNLANRSDYCGVQVFSYEELEEATENFSRELGDGGFGTVYYGVLKDGRAVAVKRLYERSLKRVEQFKNEIEILKSLKHPNLVILYGCTSRHSRELLLVYEYISNGTLAEHLHGNRAEARPLCWSTRLNIAIETASALSFLHIKGIIHRDIKTTNILLDDNYQVKVADFGLSRLFPMDQTHISTAPQGTPGYVDPEYYQCYQLNEKSDVYSFGVVLTELISSKEAVDITRHRHDINLANMAVSKIQNNALHELVDSSLGYDNDPEVRRKMMAVAELAFRCLQQERDVRPAMDEIVEILRGIKDDEKKRVLVKSPDVVDIECGGGDDVGLLRNSVPPPISPETDKWTSSSDTAASL
What are the official names of this protein?
LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 1.4, Probable receptor-like serine/threonine-protein kinase LRK10L-1.4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NU3C_SYNR3
Sequence: MFVLPGYDAFLGFLLIAAAVPVLALITNAVLAPRSRQGERRLTYESGMEPVGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFHRLGLLAFIEALVFIAILVVALAYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: TXMO_HADIN
Sequence: MRNTTFLVLNVMLLVSVALFCAADPEMEKSSFAEILDTGNPEQERKCLAEAADCSPWSGDSCCKPYLCSCIFFYPCSCRPKGW
What is the function of this protein?
Inhibits sodium channels (Nav) of insects.
What are the official names of this protein?
U2-hexatoxin-Hi1a, U2-HXTX-Hi1a, Toxin AcTx-Hi:OB4219.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 07 (Beta/delta-agtx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAA_BACCQ
Sequence: MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSELISETLYDLTGAKLAIRFIIPQSQAEEEIDLPPSKPNSAQDDSNHLPQSMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIEHNPNAKVVYLSSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQKAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLKTDTQLQKQVEEINDILK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_LACP3
Sequence: MAETSNVLRVNIVTPDGLVYDHHARMLVVHSVAGELGIMANHEPIVTPLEIGEVDVQRVDASDHNDSIAVNGGFMEVSENVASIVADSAERERDIDLSRAQAARDRAQKRIAQAKNDHNQDDLRRAQVALRRAINRINVKTSH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PGK_LACDB
Sequence: MAKLIVSDVDVKDKKVLVRVDFNVPIKDGVIGDDNRIVAALPTIKYIIENGGKAILLSHLGRIKSDEDKKSLSLAPVAKRLGELLEKPVTFVPSNEGKEVEDAINNMKDGDVVVLENTRFQDIDNDFGKRESKNDPKLGEYWASLGDVFVNDAFGTAHRSHASNVGIATAMKAAGKPAAAGFLLEKEIKFLGNAVANPVHPFVTILGGAKVSDKIGVITNLIPKADHIIIGGGMAYTFLKAQGHNIGKSLVEDDKVEFAKELLEKAGDKLVLPIDNVAATEFNNDAASEVVGQDIPDNEMGLDIGPKTIELFKKTLEGAKTVVWNGPMGVFEMPNFAKGTLEVGRALADLPDATTIVGGGDSTAAAKQLGIAPKLTHISTGGGASLEYLEGKELPGIACVSDK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_BURMA
Sequence: MSASAVNVTPGRNVVVVGTQWGDEGKGKIVDWLTDHAQGVVRFQGGHNAGHTLIIGGKKTILRLIPSGIMREGVACYIGNGVVLSPEALFKEIGELEEAGLSVRERLFISEATTLILPYHIAIDQAREARRGAGKIGTTGRGIGPAYEDKVGRRALRVQDLFDARTFADRLRENLDFHNFVLTQYLGGAAVDFQATLDTMLGYADRLKPMVTDVSRRLYEENHAGRNLLFEGAQGTLLDIDHGTYPFVTSSNCVAGAAAAGAGVGPQKLDYILGITKAYCTRVGSGPFPSELYDADNPSRQDQIGITLANVGKEFGSVTGRPRRTGWLDAAALRRSIQINGVSGLCMTKLDVLDGLDEVKLCVGYKIDGEDVDLLPRGAAEVARCEPVYETFGGWKESTVGIDSWDALPANARAYLTRVQEVAGVPIDMVSTGPDRDETILLRHPFKV
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_PSYWF
Sequence: MSDKNPQYSRILLKLSGEALAGGLGMGIDTSVLDKMSLAIAHLCGLGVQVGIVVGGGNLYRGSQLQKEGLVGRVTGDQMGMLATVMNGLAMRDALERRNINTRLMSALPIGEVTESYSSRNAIRYLKNGDVCIFVAGTGNPFFTTDTAACLRGIEIEAGVILKATKVDGVYDKDPSEHADAKKYDALTFDEVLEQKLGVMDLTAIALCREHNVPLQVFDMNKPNSLLNVIMGENEGTRVFH
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_METPB
Sequence: MSKRVQAKHKLDRRMGQNIWGRPKSPVNRREYGPGQHGQRRKGKMSDFGTQLRAKQKLKGYYGNITEKQFRRYYAEAIRLRGDSGENLIGLLERRLDAVVYRSKFVATPFAARQFVNHGHIKVNGRRVNIPSYQVKAGDVIEVKEASRQLEIVVVASQLAERDVPDYIEVDHQKMSARVTRIPGLSEVPYPVQMEPNLVIEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.