PharMolix/UniProtQA huggingface dataset:
Protein: ODP2_STAES
Sequence: MAFEFRLPDIGEGIHEGEIVKWFIKAGDTIEEDDVLAEVQNDKSVVEIPSPVSGTVEEVLVDEGTVAVVGDVIVKIDAPDAEEMQFKGHGDDEDSKKEEKEQESPVQEEASSTQSQEKTEVDESKTVKAMPSVRKYARENGVNIKAVNGSGKNGRITKEDIDAYLNGGSSEEGSNTSVASESTSSDVVNASATQALPEGDFPETTEKIPAMRKAIAKAMVNSKHTAPHVTLMDEIDVQELWDHRKKFKEIAAEQGTKLTFLPYVVKALVSALKKYPALNTSFNEEAGEVVHKHYWNIGIAADTDKGLLVPVVKHADRKSIFEISDEINELAVKARDGKLTSEEMKGATCTISNIGSAGGQWFTPVINHPEVAILGIGRIAQKPIVKDGEIVAAPVLALSLSFDHRQIDGATGQNAMNHIKRLLNNPELLLMEG
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: SSRP_CAUSK
Sequence: MTKPIAENRRARYDYFIEETMEAGLMLTGTEVKSLRVGRANIAESYASVEGRTIKLINADIPPYGHANRFNHEPRRHRTLLLHRKQIDKLIGAVQRDGRTLIPLKLYWNEKGLAKLEIGLAKGKKNHDKRETEAARDWQRDKARLMKGDRGD
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: C76B1_HELTU
Sequence: MDFLIIVSTLLLSYILIWVLGVGKPKNLPPGPTRLPIIGNLHLLGALPHQSLAKLAKIHGPIMSLQLGQITTLVISSATAAEEVLKKQDLAFSTRNVPDAVRAYNHERHSISFLHVCTEWRTLRRIVSSNIFSNSSLEAKQHLRSKKVEELIAYCRKAALSNENVHIGRAAFRTSLNLLSNTIFSKDLTDPYEDSGKEFREVITNIMVDSAKTNLVDVFPVLKKIDPQGIKRGMARHFSKVLGIFDQLIEERMRTGRFEQGDVLDVCLKMMQDNPNEFNHTNIKALFLDLFVAGTDTTSITIEWAMTELLRKPHIMSKAKEELEKVIGKGSIVKEDDVLRLPYLSCIVKEVLRLHPPSPLLLPRKVVTQVELSGYTIPAGTLVFVNAWAIGRDPTVWDDSLEFKPQRFLESRLDVRGHDFDLIPFGAGRRICPGIPLATRMVPIMLGSLLNNFDWKIDTKVPYDVLDMTEKNGTTISKAKPLCVVPIPLN
What is the function of this protein?
Capable of dealkylating a model xenobiotic compound, 7-ethoxycoumarin.  Metabolizes with high efficiency a wide range of xenobiotics, including alkoxycoumarins, alkoxyresorufins, and several herbicides of the class of phenylureas.  Catalyzes the double N-dealkylation (oxidative N-demethylation) of phenylureas such as chlortoluron and isoproturon with turnover rates comparable to those reported for physiological substrates and produces non-phytotoxic compounds.  Could be used for control of herbicide tolerance and selectivity, as well as soil and groundwater bioremediation.
What are the official names of this protein?
7-ethoxycoumarin O-deethylase, ECOD, Cytochrome P450 76B1, Phenylurea dealkylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: SOMA_MOUSE
Sequence: MATDSRTSWLLTVSLLCLLWPQEASAFPAMPLSSLFSNAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKEEAQQRTDMELLRFSLLLIQSWLGPVQFLSRIFTNSLMFGTSDRVYEKLKDLEEGIQALMQELEDGSPRVGQILKQTYDKFDANMRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
What is the function of this protein?
Plays an important role in growth control.  Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1.  It stimulates both the differentiation and proliferation of myoblasts.  It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PUS2_ORYSJ
Sequence: MATTAAASPPAIATALSALLRRQRRRSSRCVGASHARCLAADANAEAVAPSRRGGHGGTRLEEAVPAGEGRSRIDAWISARLGGGGVSRARIQASIRAGLVVVNGRPVSKVSHMVKGGDIVSCTVLELQPLRAEPEDIPLDIVYEDDHLLVVNKPAHMVVHPAPGNANGTLVNAILHHCKISTFTCLARNSIDDECPDSSDDDIDVFDIDQFTTGEVSSEVREALVRPGIVHRLDKGTSGLLVVAKDEHSHAQLAEQFKLHTIRRVYISLTCGAPNPNSGRIEVPIARDPNNRIRMIATPGSGHRYARHAASRYKVREVFAGGGSALVEWRLETGRTHQIRAHAKYLGIPLLGDETYGGTKSMALSLLRPRTPSRYHCDLSNMISKIDRPCLHAALLGFKHPHSGKILEFSCPPPDDFTEVLNELHQVTLASNGNSGGGVARICD
What are the official names of this protein?
RNA pseudouridine synthase 2, chloroplastic, RNA pseudouridylate synthase 2, RNA-uridine isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: QUEA_CLOAB
Sequence: MQLEDFDYYLPEELIAQHPCDKRDECRLMVVDKKSGEVEHRIFKDVIDYLNPGDCLVLNDTRVLPARLIGNKVGTGGKMEFLLLKRIDKDTWETLVKPGKRAKVGAEFEFGGGVLKAVIKSIGEDGNRVVEFKYEGIFEEILDKLGQMPLPPYITEELENKEEYQTVYSKNNGSAAAPTAGLHFTNELLDKIRAKGIKTVFLTLHVGLGTFRPVKVENIESHHMHSEYYMLSKESADTINETRKNGGRIISVGTTSTRTLETIADEKGNVREQSGWTDIYIYPGYKYKIVDGLITNFHLPKSTLVMLVSALSSRDNILNAYKIAVENRYRFFSFGDAMFIK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVSE_BACAN
Sequence: MIMRFGYVSHAMALWDCSPAKTITFTSFQKLSKQEREDKLYDVTKQNLEHTIRILHYNIAHEIPLYRLSSSIVPLATHPEVEFDYIGAFTPLWRKIGALIKEHNLRISFHPNQFTLFTSDKPHITTNAITDMTYHYKVLDAIGIADSSYINIHVGGAYGNKEKAIERFHENIKKLPAHIKKQMTLENDDKTCTTAETLSICQKEKIPFVFDYHHHMANLCEEPLEELLPAIFETWSHTNIVPKVHISSPKSKKEFRAHAEYIDLEFIKPFLHVAKKINHNFDIMIESKQKDLAMLQFIQELSSIRGIKRISSSTLQW
What is the function of this protein?
Component in a DNA repair pathway.  Removal of UV LIGHT damaged nucleotides.  Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion (By similarity).
What are the official names of this protein?
UV DNA damage endonuclease, UV-endonuclease, UVED.
What is the protein family that this protein belongs to?
Belongs to the uve1/UvsE family.
Protein: ZN503_XENTR
Sequence: MSNSPLGSGSRISHFTTESTDRGDERASFSSRAFIHTVPPSDPQRQAGRLPIKVLKMLTARGGHILHPEYLQPLPSTPVSPIELDAKKSPLALLAQTCSQIGKPDPAPSKLSAVTGSSASGDKESKSVPLKLSDIGAEDKSSFKPYSKHPDKKDQSASDKSGFRVPSAACPPFTPRTGSPGSPRTPPPPSEPKASSECTDKKEMEQCAKTAPPDGSAHGRLSTELTHSEGTAGCKSLSAAPSPTPASSSSSSSSVLGSGLVAPVSPYKPGHTVFPLPPASMSYPATLAGAYAGYPPQFLAHGVSLDPSKGSSLVGAQLSTLGCTGKSAASSPLTGASPPSVMTASLCRDPYCLSYHCASQLGAGATCAHDLKSGYPLVYPSHALHGVSPPSLPGHPLYPYGFMLPNDPLPHVCNWVSATGPCDKRFSSSEELLGHLRTHTAFPGATDKLLPGYPSSSSLAAAAMACHMHMPPTGASPGPLTLRSPHHHPLGLSSSRYHPYSKSPLPSGGAPVPMPAATGHYYSPYALYGQRLTTASALGYQ
What is the function of this protein?
May function as a transcriptional repressor.
What are the official names of this protein?
Zinc finger protein 503.
What is the protein family that this protein belongs to?
Belongs to the Elbow/Noc family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOXQ1_RAT
Sequence: MKLEVFAPRAAHGDKMGSDLEGAGSSDVPSPLSAAGDDSLGSDGDCAANSPAAGSGAGDLEGGGGERNSSGGASTQDDPEVTDGSRTQASPVGPCAGSVGGGEGARSKPYTRRPKPPYSYIALIAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRRKRLSHRTTVSASGYGGGSPPGPAGTPQPAPTAGSSPIARSPARQEEGSSPASKFSSSFAIDSILSKPFRSRRDGTPALGVQLPWSAAPCPPLRAYPALLPASSGGALLPLCAYGAAEPTLLASRGAEVQPAAPLFVAPLSTAAPAKPFRGPETAGAAHLYCPLRLPTALQAAAACGPGPHLSYRVETLLA
What is the function of this protein?
Plays a role in hair follicle differentiation.
What are the official names of this protein?
Forkhead box protein Q1, HNF-3/forkhead-like protein 1, HFH-1, Hepatocyte nuclear factor 3 forkhead homolog 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSCA_RICPR
Sequence: MQIIEITEPKQTDFQQKLQIAVGIDFGTTNSLIAIATNRKVKIIKSIGDKELIPTTIDFINEDLIIGNNKGLHSIKRLFGKTLKEILNTTTLFSLVKDYLDINSSELKLNFANKKMRIAEIAAEVFIYLKNQAEKQLKNNITKAVITVPAHFNDAARGEIMLAAKIAGFEVLRLIAEPTAAAYAYGLNKNQTGRYLVYDLGGGTFDVSILNIQEGIFQVIATNGDNMLGGDDIDVVITQYLCNKFDLPHSIETLQLAKKAKEILTYKESFNNDIISINKQTLEQLISPLVERTINITQECLEQSGNPNIDGVILVGGTTRIPLIKDELYKAFKIDILSDIDPDKAVVCGAALQAENLITQHTNSLLIDVVPLSLGIELYGGIVEKIITRNTPIPIAVIKEFTTYADNQTGIQFHILQGEREMAADCRSLARFELKGLPPMKAGNIRVEVTFAIDADGILSVSAYEKISNISHNIEIKPNHGINKTEIETMLKNAYKNAKIDYTTRLLQEAVIETEALMSSIERSIIKLTKLLSESEISIINALLDNIKDAVQTRDQILIKNSIKEFKSKIKKYLDTKLNINDLRKCKNSNQIK
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity).
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PDXH_ECOSM
Sequence: MSDNDELQQIAHLRREYTKGGLRRRDLPADPLTLFERWLSQACDAKLADPTAMVVATVDEHGQPYQRIVLLKHYDEKGMVFYTNLGSRKAHQIENNPRVSLLFPWHTLERQVMVIGKAERLSTLEVMKYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVSLEQIEFWQGGEHRLHDRFLYQRENDAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RLMN_ECOL5
Sequence: MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSD1_HUMAN
Sequence: MVRGAGPGPSLSALSHPTGASGMAAAEGPGYLVSPQAEKHRRARNWTDAEMRGLMLVWEEFFDELKQTKRNAKVYEKMASKLFEMTGERRLGEEIKIKITNMTFQYRKLKCMTDSESAPPDWPYYLAIDGILAKVPESCDGKLPDSQPPGPSTSQTEASLSPPAKSTPLYFPYNQCSYEGRFEDDRSDSSSSLLSLKFRSEERPVKKRKVQSCHLQKKQLRLLEAMVEEQRRLSRAVEETCREVRRVLDQQHILQVQSLQLQERMMSLLERIITKSSV
What are the official names of this protein?
Myb/SANT-like DNA-binding domain-containing protein 1.
Protein: MUTS_ACIAD
Sequence: MNSTETMADLSSYTPMMQQYFKVKLEHQHALLFYRMGDFYELFFDDARKAAKLLGITLTHRGKANGEPIPMAGVPYHAAEGYLARLVRAGQTVAICEQVGEGENAGSRCKAPMERKVVRIITPGTITDDALLGSYQSSNLVALCIQQNKIGIALLDLSASIFKVQQHEFKTEQLYIELARLMPSEIVVDEDLVDQNILEQIKKQIECSITKRPNVDFNLNNAQKTLCDQFGVTTLSGFGIDHLPLAKAAAAALIHYAKETQKTALPHIRSIQLEQSTDFIALDPITRRNLEIIDPLFEHGTSLFNLINDCQTAMGGRLLSRILMQPIRDTAILDARLDATEQLLIGYHESPVRLVLKEIGDIERVLSRVALGTARPRDLVQLRQACAQIPFLRHALLPAIQTKSSKLLNELDHELGDFKDLHQLLLSAIVENPPVLLRDGNVIAEGYDAELDELRKIRDHAGQFLVDLEIKERESSGIPTLKIGYNRVSGYYIELTRAQAEQAPAYYIRRQTLKNAERYITPELKSFEDKVLSSESRALAREKLLFESLLETLKKNIANLQMMSSAIAQIDVLANFAHQARLQNWNRPDFSPEIGIKIHDGRHPVVEALSKTPYTPNDTFLDSQHRMAIITGPNMGGKSTFMRQTALISLLAYCGSYVPAKSAKLGPIDRIFTRIGSADDLSTGKSTFMVEMTETSQILHHATHQSLVLMDEVGRGTSTYDGLSLAWACVLDLTKRIKCLCLFATHYFELTELGSESAIDNYHVTAKEMNGNLILLHKVQHGPASQSHGLQVAKLAGIPASVIKEAQKRLKILEKQQQQYFQTAVQNDLFAIPELPQIDETKIEIKKTSPVLDHLKQLDVDSLTPRQALEALYQLKDQLEH
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CLH_DICDI
Sequence: MTNLPIRFQEVLQLTNLGIGSNSIGFSTLTMESEKYICIRETTPDDKNNVVIIDTDNPSQILRKQMKTDAAIMNPKEPILALKIGQVLQLISIEQKMQLKSCQMQEPLEFWKWISPNTLALVTATSVFHWTKEGNSDPVKVFDRHPDLQNTEIINYRSDSTQNWLVLVAIHQRDGRVVGRIQLYSVEKQISQSIEGHAACFANYIVPGATRPSTLFAISSRTQNASKILVLEVSKGDGPNFQKRASDVFYPPEIGASDFPVAMQVSEKYEVIYMVTKLGYIHLFDLGTANLIYRNRISNENIFVTAFEESTNGIIAVNRKGQVLSVSIDDKNIIPYICNTLNNLELAISMACKNNLPGAEGLLTTQFERYFQQGQYKEAAKVAADSPGSILRNLQTIQKFQSIPPIPDQPSALLQYFGMLLEKGKLNKVESLELVRPVLAQGKKPILEKWLTEDKLECSEQLGDEVRPHDRKLALSIYYRANASDKVITLFAETGEFDKIIAYCKKFNYKPDFMFLLQRMANANPMGAADFAVKLVKEEGGPYIDANQVVELFSARNMIQETSNFLFAILDGDRPQDANLQTKLLEINLLHAPQNADAIMGGQKFTHYNRLRIGGLCEKAGLYQRALEHYTDLADIKRVLSHAGHMVNQEFLVSYFGSLNPEDRMECMRDFLRTNPRQNLQLVVAIAVSYSDQITPEAIIAMFESFRLYEGLYLYLTQVVVTSTSPEVHFKYIEAAAKINQFKEVERMCRDSNYYDPEKTRDFLKEAKLPDQLPLIIVCDRYEFISDLTNYLYKNNLSKYIEAYVQKINPVNTPLVVGALLDLDCQEDYLRNLIMSVRNMCPADSLVEQVEKRNRLKLLLPWLEARVAEGNIEPAIHNALAKIYIDSNKNPEAFLLHNQFYDSKVVGKYCEKRDPYLSFVAYKRGLCDYELIEVTNKNTLFKNQARYLVERQDPDLWAYVLSDQNEYKRSLIDQVVQTALPESTNATEVSATVKAFMDANLPNELIELLEKIVLEGKEFKTAKELQNLLILTAIRADKSRVTDYINRLDNFDGSKLAPIAIESQLYEEAFFMYKKFQFNVEAIDVLITHIGSIERAHDFAERCNQTEVYSKLGVAQLKAEMVKECIESFIKANDTEHYQEVVAAAERKDEYEDLVKFLQMCRKKIKEPAIESELIFAYAKVNKLAEMEDFINSPNSAHIQVVGDRCFENGLYEAAKVLYTNISNFSRLTSCLVKLGQYQAAVDAARKANSTKTWKEVSAACIDAKEFRLAQVCGINIIVHGDELEELIRQYEDRGYFNELISLLESGLASERAHVGMFTELAILYSKYKEEKLMEHLKLFYSRLNVPKVIKACQANQQWPQLTYLYIHYDEHDNAIQTMINHSIEAWDHVLFKETIPKVAKLDLYYSAISFYLEEQPLLINDLLSVLSPRIDHTRAVTLIRSLGHLPLVKPYLVSAQDQNVAALNEALNELYVEEEDYESLRSSIDANSNFGTIALAQKLEKHELLEFRRIAAYLYKKNNRWAQSVELSKKDKLYKDAIQSASDSKNPAIGEELLQYFVDQQNNSAFAACLYTCYDFLKPDAVIELAWRNNILNYSFPYLIQYVKEYTTKVDQLVDDFKARQKKTEEEKEQQNIESSQYQPDLTNLSYGYAATGGMLALPPAVGYQQQQQPQQMYNPNQMMGGFQQNYNQYGGF
What is the function of this protein?
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
What are the official names of this protein?
Clathrin heavy chain.
What is the protein family that this protein belongs to?
Belongs to the clathrin heavy chain family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles. Localized to punctae scattered within the cytoplasm, along the plasma membrane and concentrated in the perinuclear region. Localizes to the posterior plasma membrane in cells which retract their tails when moving forward or changing direction. Recruited to the plasma membrane under the tight cap of cross-linked receptors prior to internalization of the capped ligand. Does not localize to the plasma membrane during phagocytosis.
Protein: HEMH_YERPS
Sequence: MMQSKPGVLMVNLGTPDAPTSKAIKRYLAEFLSDRRVVDTSPLLWWPLLHGVILPLRSPRVAKLYQSVWMEEGSPLLVYSRRQQKALAARMPDIPVELGMSYGSPNLPEAIEKLLAQGVTNLVILPLYPQYSCSTSAAVWDAVARVLKGYRRLPSISFIRDYAEHPAYISALKQSVERSFAEHGQPDRLVMSFHGIPKRYAQLGDDYPIRCEDTSRALRAALPLPAEKIIMTYQSRFGREPWLTPYTDETLKSLPSQGVKHIQLICPGFSADCLETLEEIKEQNREFFLHAGGEKFEYIPALNDDEGHIALLEQLIRHNI
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD061_YEAST
Sequence: MSTNKFVVRITNALFKSSLASNSPPVYPKRIRHFEILPNEKWVIWGPGKGKFLDVLNNKYICEPPLSLRFGFLKESSNILPRIEQVAFKGVMPTAHLSARYEYFKDDYDQTCKQFIFDKASGSNAVSYKVETNNRQINMELYNALVENLNLSSLQDRWVMGLSNGQMRRARLARSILKEPDLLLIDDPFLGLDPAAIATISQFLAKYDSIEVSGGCPIVIGLRYQDTIPAWCTHICCVDEKNGILFEGPIEKLQSKMDETRSRALKELEQLKKASNSKEDISINDLICIHPMYGKKEHEIIKMPHLIELDGLSVSYKGEAVLENLHWKVQPGSKWHIRGDNGSGKSTLLSLLTAEHPQSWNSRVIDNGVPRRTGKTNYFDLNSKIGMSSPELHAIFLKNAGGRLNIRESVATGYHEASSNNYLPIWKRLDKNSQEIVNMYLKYFGLDKDADSVLFEQLSVSDQKLVLFVRSLIKMPQILILDEAFSGMEVEPMMRCHEFLEEWPGTVLVVAHVAEETPKCAHYLRLISPGEYEIGDMEN
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YDR061W.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: BIOB_CELJU
Sequence: MNASFAPSSSFVAGLRHDWSRAEIKALFELPFSDLMFQAQSVHRAWFNPNEVQVSTLCSIKTGACPEDCAYCPQSARYDTGLEKEKLMAVEKVIEEARAAKASGATRFCMGAAWRSPKGKDMPYVTAMVKGVKSLGMETCMTLGMLSEAQAQDLADAGLDYYNHNLDTSPEYYGEIITTRTYQDRLETLDNVRKAGMKVCCGGIVGMGEEVLDRAGLLQQLANMAEHPESVPINMLVKVGGTPLEREADLDPIDFIRTIAVARILMPKSHVRLSAGREQMNEQTQALAFLAGANSIFYGEKLLTTPNPEANKDMQLFNKLGIKPEAYDVHETEEEQEAALVHQLEEAKLDAFFYNAAR
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: GPMA2_LACPL
Sequence: MAKLVLIRHGQSEWNLSNQFTGWVDVDLSEKGVEEAKAAGQKVKEAGLEFDYAFTSVLTRAIKTLHYVLEESDQLWIPETKTWRLNERHYGALQGLNKKETAEKYGDDQVHIWRRSYDVLPPLLSADDEGSAVNDRRYADLDPNIVPGGENLKVTLERVMPFWEDQIAPKLLDGKNVIIAAHGNSLRALSKYIEQISDDDIMDLEMATGEPVVYDFDEKLKVLGKEKLGK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2, BPG-dependent PGAM 2, PGAM 2, Phosphoglyceromutase 2, dPGM 2.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: RPOC1_SYNPZ
Sequence: EVTKPETINYRTLKPEMDGLFCEKIFGPSKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGFIKLAAPVSHVWYLKGIPSYVAILLDMPLRDVEQIVYFNCYVVLDPGDHKELKYKQLLTEDEWLEIEDEIYAEESEIENEPVVGIGAEALKQLLEDLNLEEVAEQLREEINGSKGQKRAKLIKRLRVIDNFVATSAR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: CM317_CONRE
Sequence: TICLLLFPLTVVPLDGDQPAHQPAVRKHNIKSAVQLRQWDEEQQCCTGQCHICWPCC
What are the official names of this protein?
Conotoxin reg3.17, Rg3.17.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYIF_MAGGR
Sequence: MLPSFIFVYSLLATATATSPDWPEPWPSHWREPGSDLFPNQQVHLAVEEAGTGSGCRISNITSNEMAKGRTIVDFPLYAVGSLEEPKLQPLNSSGGEQWEFDGVSEDGMQSFIFGFYRDPNYAILGTGNLRVSIEFGFEDRTRFSEVYYAQRSVVETCSLGTRGLWVDKEAGWKFSFLVDAAMQEAIITLDSDTVKGRIIITSRAKPLAADGSTWPAENASTVTIPYYYWSQPIPAGTVETNVEIKGKLIKWKGMGGHERFWSSFSWFTCMRSLQAVRAMLGPYVLSYFSFTSNLIPDLTHQSVVLFHDGAVVFRSTLGTPSETEDYATVTKTYGGATTGTLKDKVTGFQLELVSPSKMRHYTFFVEHLNVGFEYILGEGVGGSGFSSQSRGGHVGLDQHEGVALTEALTFPKNSPLFRSNYV
What is the function of this protein?
Diels-Alderase; part of the gene cluster that mediates the biosynthesis of the mycotoxin pyrichalasin H, a tyrosine-derived cytochalasan that inhibits the growth of rice seedlings, but also inhibits lymphocyte capping and actin polymerization and alters cell morphology (PubMed:31099577) (Probable).  Pyrichalasin H is indicated as the responsible agent for the genus-specific pathogenicity of M. grisea toward crabgrass (PubMed:31099577).  The first step in the pathway is catalyzed by the O-methyltransferase pyiA which methylates free tyrosine to generate the precursor O-methyltyrosine (PubMed:31099577).  The hybrid PKS-NRPS pyiS, assisted by the enoyl reductase pyiC, are responsible for fusion of the O-methyltyrosine precursor and the polyketide backbone (PubMed:31099577).  The polyketide synthase module (PKS) of pyiS is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the O-methyltyrosine precursor (PubMed:31099577).  As the NRPS A-domain demonstrates substrate tolerance, pyiS can also use phenylalanine, tyrosine and even para-chlorophenylalanine as amino acid precursor, which leads to the production of novel cytochalasans, including halogenated cytochalasans (PubMed:31099577).  Because pyiS lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase pyiC (PubMed:31099577).  Reduction by the hydrolyase pyiE leads to 1,5-dihydropyrrolone, which is substrate for dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase pyiF to yield the required isoindolone-fused macrocycle (PubMed:32039410).  The tailoring cytochrome P450 monooxygenases piyD and piyG catalyze the hydroxylation at C-18 and C-7, respectivily, whereas the short-chain dehydrogenase/reductase pyiH reduces the carbonyl at C-21 in preparation for the transfer of an acetyl group by the acetyltransferase pyiB (PubMed:31099577).  These 3 reactions whose order is not clear yet, lead to the production of O-methylpyrichalasin J, a deacetylated pyrichalasin H.  Finally, pyiB to converts O-methylpyrichalasin J into the final product pyrichalasin H via acetylation of C-21 (PubMed:31099577).
What are the official names of this protein?
Diels-Alderase pyiF, Pyrichalasin H biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the Diels-Alderase family.
Protein: G6PI_ACIBC
Sequence: MSKSIEKFPKELVSPIAQLHSLVEKNSKLHIKELFAAEQDRFQNYSVKFDQLVFDYSKHRITKSVLEQLFALAKTKQLTHWIERLFSQDKVNCTEQRAAMHWALRLPSEYSKFPELTKQVHNQLQRMYALVEKIHAGQYRGATGEVIQDVVNIGVGGSDLGPQMVTHALCDFKVKTAKPLNVHFVSTMDGSQLSDLLHQLRPETTLFIISSKSFGTIDTLSNAQTVRQWLEKALGKHDRVVKSHFIGVSTKAEKMTEWGIAPDNQLLLWDWVGGRYSLWSCIGFPIALTIGIDGFQQLLAGAHAVDEHFQNTGFEQNIPVLMALLGIWNNNFLNIQTHAVLPYDGRLKYFAAYLQQLEMESNGKSVQRDGQKVELDTCPIVWGEVGPNAQHAFYQLLHQGTQAVSCDFIAPIQRYNADHFTYVENAEALIEQHHLALSNCLAQSRLLAFGNEALDSAELKNLPIYKQYEGNQPSSTLLLKELNPYSLGMLIALYEHKVFVQSVIWNINPFDQWGVEKGKQIADQLLPILNGAQNDLSTLDASTRGLIKILLGKVDG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.