Protein: APDA_EMENI
Sequence: MQDLIAIVGSACRFPGQSDSPSKLWTRLKEPIDLRKTFPPQRLNLARFYHPDGEHHGSTDVRGTSYLLSEDPRQFDASFFNINPREAEGMDPQQRLLLETAFEALEAAGYSLEAMNGSKTSVHVGVMNSDFSNIQLRDPEVLPTYNATGTAISILSNRLSYFFNLKGPSVTIDTACSSSLVALHQAVQGLRAGDATAAIVAGANLIFDPAMYIAESSLHMLSPDSCSRMWDKDANGYARGEGVGVLVLKPLSRAIMDGDHVEAVIRSTGVNSDGRTKGITMPNAESQTELIRQTYRDAGLDPIRDRCQYFECHGTGTATGDPIEARAVHDAFFPTETRTASNTLIPDGKLYVGSVKTIIGHLEGCAGIAGVLKAVLAIKNRTIPPNMHFHEPNPRVIPFCDRLEIPTVPIPWPDTGRSPLRASINSFGFGGTNAHAIIEGYDALSSPVREATITPDDLFIGPLLFSANSSSSLVANVKNMAERIRSDPSIDLESLVWTLYARRSVLPVKAFFTGGTVQRLLNFMDRFVAESEETTSSTAGIKYQPLNPTETPGILGIFTGQGAQWALMGFSLLQQNHVFRAAIERCQAALATLHDSPSWSLLDELVKGADESRIGEAALSQPLCTALQIGLVDMLHSAGIKLDAVVGHSSGEIAAVYAAGIINADAAIKIAYYRGYYAKLAAGARGQAGRMMATAMSFDEAEEFCAQPQWRGRLAAAASNSPQSVTLSGDIDAIEEALQLFEAEKKFARILRTDTAYHSHHMQPCAERYLKSLQACQIKVSPPRKDCVWISSVRGDTQLLEGDLSTLADQYWVDNMCNPVLFSQAVETSIWNGGPFDVAVELGPHPALKGPVEQTIKAVYGPIPAYAGLMRRGDNEIEAFSGGVGFVWSRLGPDYVDMSGYRKGFIGADRLRPQVLKDLPVYCWDHSKLYWKESRISRQYRLRQDTPHELLGRRVPDDSDDSRRWRNVLRLSELPWIRGHVFQGQVLFPGAGYVAMALEAARELTEGRPATLFEIENVSLRRALVISEQAGIETAFTARVIDAKEGRNDTNRLEADFACYFCSAEGNEPLVKACTGRLIINYGDPAAEALPQRTRLPSNNVPVDMGRFYDAMNSVGLDYQGIFRGLVHGKRSLGCSSVKAAWGEDMQIDNYVVNPGFLDVAFQSVYTAFSSPASGEIWAPYLPIHIERLAVNPNVSYRSAKDEVQMEADAFVTVSNSTLLKGDIQLYQIDSQHAAIQVEGISMKSMSEPQPENDRCLFSETVWGPDVSLGVSEVTSRATEDDTPLVEALDRVSLFYWQNLLQEVGAEEIAQFQWYHQRMFDAVRFQVSSVRSGQHPIAKPEWLEDDWETILAVSEPYASRVDMRLIHAVGENLASVVREDTQLLEVMVQDDMLNRFYMEGYGFSVINNAVSDALEQITFKYPHANILEIGAGTGGTTRSILDRIGSRYGSYTYTDISPAFFEAAAEKFEDAREKIQFKVLDVEKEVGAQGFDEHGYDVIVAANVLHATRKLEETMKNARALLKPGGYLVLMEITGPDVLRTQFIMGGLPGWWYGVDDGRVLSPAISAQQWNQLLLDTGFSGLDCLAPDMLDEYKHSFSLMVSQAIDEKIQMLRDPVLSKTLLPAADVLIIGGRTHSNVIHEIRRYLSAWTSRVEVWDRIQTKQLDQLAEFENIICLEELDQPLFSTTMTSETLLALQKVLSGTKNVVWAINSAKSQNPHVNMTVGLGRAMRTEVPGLNLLFVDIDAVENPIACAQLLSQMLLQLRTGSLTAAENTLWAAELEIRVQDGRRLIPRVLPMTQMNETYNASRRVISKPVDIETTCVKMEDSAGSLRLVPGACMVDGPVQRGHNRLRIHRSLPLAFGGGTPCYLCSGDLRENGLPALALSTSNANLADIPNDMVFALDQDQPCDAAMLEATGRQLLARDICNRLPASNRILVYQPSHDFAQALLLTGRHFSFVSADKASCFSDWVYIHSRASRRAIQSRLPKDFDALIDCTGELPENLIACLSRNCRVLNMTLHQLDGSLLGPAYSAALAHVSSSSIGPSIRVKDLPLATPSKLPMVDWTGVDTVELTLQPLSMRKLFSSSATYLLAGMTGDLGLSLCRWMIDNGARNIALTSRNPNVGEELLQDMRRSGADIRVFRNDITDQNAVRTLVENIRLSMPPIAGVFNACMVLRDGLFSEMDVDTLNDPLAPKVDGSKILDDIFQDDSLDFFVLFSSLASIIGNAANPTTTLQTCSSLVLPPTAARRVWQPSPHNSSRQHEIILGLEPFIDSPNATKRPPWEHNPMFSHYVSRPLLQETPAATTVEAAADVKQLLRSTVSGEAVIPIVQEAFARKLESMMQLPANSINLNVPLIDLGCDSLLAIEIRRWFIKELGIDVPVLKVLSGDTTAQICEDAVRQFLALQLEKQDTVAPNMTEKPETKSHPSSNATIIDNDALDKADAANGDYESSSQGDDSRGNSSSSSSHTSPSIQATTPDIKPNTPVPLDVDADPLGRGFQRTMIRAEPASFAQSRLWFLTQYLHDPTTYNVTVRYDVRGNLPASRIVSSLNRTICHHQSLQTCFFMDSDKETLMQGVLSPSYSSIKHIPSGSEQTVREEYNRLRSRVWDLQKGETFAVTVVSLSPEQHTIIFGYHHIVMDGVSWHLFLRDLDLAYRLRPLPSIEMEYIDWSKKQFQSAQRGDFTRPLEYWRKQHSPPPSVMPLLPMAQTSSRKPLTSYDSHVISVQIDRQLVSHIRLVSQSLGVTPFHFHLAVIQSILCRLLKTEDLCIGVVDANRTSEAHSGTVGFFLNLLPVRFTTREHSTFQDLVSSTKRTILGAISNSEAPFDLILEDLKVLRSIEHSPLFQVAVNYRMGAMLQVPLGDGTMEVAAADDAKNPYDLSFGITETSTGTCLLELTSQKQLYTEQSTELLLQMYMDVLRASSDNPSLPVNQLPVTLEPSTGKALAVAKGPRAEYSWPNTLWERYDAIRKSFPEETAIKDGKSELSYSQLTRSVEKLAAMLISQGVTAGDSVGVLLHPSIDAIACMLALLRVGCIYTPLDTRLPVARLSIIVNRSKSSLVLYHASTHDVALELGKFSKLANVEDMCESGQAQVPAIAPQSNPASFLFYTSGSTGTPKGILLSQQNFVNHLAAKTDKLNLGREVVLQQSSLGFDMSVVQTFCALGNGGTLVIAPKEARGDPIALSTIMAKERVTLTIATPSEYSLLLRFGLEQLQRPYSWRHACMGGEVVSRQLVQQFCQLDHPDLQLTNCYGPTEITAAATFQDISLQMKDQSTTDGSLVGKALPNYSVYIMDASSGSPVPIGVTGEICIGGAGVSLGYLNSLEQTDAKFVRDPFASPEDITRGWTKMYRTGDMGCLTEDGTLIFMGRMDGDNQVKLNGLRIELDEIANSILTTGNDLVSEAVVTVHSGSGSGSPLLVAHVVPLGDNVDNSRLQQLARDLPLPQYMLPSVVVSLDRLPINANGKVDRKAIMALPLPTQRTESAAGTGTDTARHLSLAEGELRLLWEKVLPASGGPSRLDADSDFFMRGGTSMLLVRLQGAIKESIGVSIPVAELYQFPTLGQMARRISRRKEDHQASHATVINWDSETALTQDLIYAAKNQFSTRQTKAHDRQDILLTGSTSFLGKNILQSLLHNPLVERVHCVAVPAEDIPRLPASEKISIYTGSLLTPSLGLTKTEIAVLQSSLDVIIHAGSTGHCLNNYSSLRASNVDSTKFLAAIALLCRIPIHFISSNRVTLLSGSTSLPPASVSSSLPNTDGSEGFTASKWASERLLESVANLASGLPVTIHRPCAVFGEEAPNEDALNALLKYSKLTRCVPRFENFEGYLDFEDVHRVAATIAADALSAESRESKSAARVRHHSSGHKVSMKDFKGRMETLFACPFKEVSMAEWTERALQAGIDPLITGYLEAMTMKGEIIRFPYMGEAGSL
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of aspyridones (PubMed:17369821, PubMed:20828130, Ref. 5).  The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA (PubMed:17369821, PubMed:20828130).  The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit (PubMed:20828130).  The growing polyketide chain then elongates into a tetraketide (PubMed:20828130).  The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation (PubMed:17369821, PubMed:20828130).  Alpha-methylation step during polyketide synthesis is a prerequisite and a key checkpoint for chain transfer between PKS and NRPS modules (PubMed:25494235).  The downstream NRPS module contains the condensation (C), adenylation (A), and thiolation (T) domains and catalyzes the incorporation of tyrosine via the formation of the L-tyrosinyl-thioester and the amide linkage between L-tyrosinyl-thioester and the tetraketide (PubMed:20828130).  The bimodular assembly line is terminated with a reductase (R) domain that facilitates formation and release of the tetramic acid product (PubMed:20828130).  Because apdA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase apdC (PubMed:17369821, PubMed:20828130, Ref. 5).  ApdC appears to operate with different stereoselectivity in different PKS cycle (Ref. 5).  Combined with apdC, apdA is proposed to synthesize preaspyridone A via about 20 enzymatic steps (PubMed:20828130).  A number of oxidative steps performed successively by the cytochrome P450 monooxygenases apdE and apdB are required for the conversion of preaspyridone A to aspyridone A (PubMed:17369821).  The cytochrome P450 monooxygenase apdE is responsible for the oxidative dephenylation of preaspyridone A (Ref. 5).  Finally, the predicted FAD-dependent monooxygenase apdD and the acyl-CoA dehydrogenase apdG may be involved in the transformation of aspyridone A into aspyridone B (PubMed:17369821) (Probable).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase apdA, Aspyridones biosynthesis protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.