PharMolix/UniProtQA huggingface dataset:
Protein: CHLD_SYNY3
Sequence: MTTLTPFIPLNFPITAIVGQEAIKLALLLGAIDPGLGGIVIAGRRGTAKSVMARAIHTLLPPIEIIKGNRYQCDPKNPGSWDDDTLEKFADVPLDQLETQVIPAPFIQIPLGVTEDRLLGSVDVEKSVKQGEAVFQPGLLAQAHRGVLYIDELNLLDDQIANQLLTVLTEGKNQIEREGMSFQHPCQPLLIATYNPEEGPLRRHLLDRIAIALSADGILGLDQRVAAVDQVLAYADSPISFIDQYDAELDDLKTTIILAREWLKEVSLTPEQVSYLVEEAIRGGLQGHRGELFAMRVAKAIAALDGRSDVQADDLRQAVELVIVPRSVLMDNPPPPEQAPPPPPPPQNQDEGKDEQEDQQDDKEDDKDNEPEAEQDPPSIPEEFIFDPEGVSLDPSVLYFAQMAQKQGKSGSRSVIFSDDRGRYLKPILPKGKVRRIAVDATLRAASPYQKSRRLRHPDRQVIVEQGDIRGKKLVRKAGALIVFLVDASGSMALNRMQAAKGAVMQLLTEAYENRDQVSLIPFQGENAEVLLPPTRSIAMAKKRLETLPCGGGSPLSHGLMQAVNVGMNAKRSGDIGQVVIVAITDGRGNIPLARSLGDEIPEGEKPDIKAELLEIAAKIRGLGMQLLVINTEKKFVSTGFGKELAQKAGGKYYQLPKATDQGIASMARQAIADMQ
What is the function of this protein?
Involved in chlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
What are the official names of this protein?
Magnesium-chelatase subunit ChlD, Mg-chelatase subunit D, Mg-protoporphyrin IX chelatase.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunits D/I family.
Protein: MOAC_TRIV2
Sequence: MQDPFPKNSANLTHLDGQGQAQMVDVSDKVQTIRQAVAEAQVRMLPATLAAIQAGNTPKGDVLATARLAGIMAAKQTANLIPLCHPLPLQKVAVEITPDPQLPGYQIRATVKTKAETGVEMEALTAVSIAALTLYDMAKALEKSMQIESIRLVSKTGGKSGDYFPPAP
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: SYC_CAMLR
Sequence: MVFFDSVLKKKCEFIPHEAKKANIYLCGPTVYDDAHLGHARSSVCFDFLRRVLLASGYEVVFARNYTDIDDKILKKMQESGKSLKEITNFYIKRYEEDMQALNILEPDFKPKATAYIEQMITYIEKLLELNLAYKLEDGIYFDTSKDDKYFYISKRNLEDNQSRLEESVAKKNDSDFVLWKFDEKFYPASFGKGRPGWHTECVVMIESIFKDKLDIHAGGIDLLFPHHENEACQCRCKNNHELANFWLHNGFVQINGEKMSKSLGNSFFLKDSLKLFNGEVLRFYLLSVHYRAHFNYALEDLQAAKKRLDKFYRLKKRLNLNAFIDEKTIIESKVSQNILDVLNDDLNASKALALLDEFINESNIYLDQNPKDKAYKIQLEKTLKELSFIFGIGFIDTIKYFQFGISEEKCQEIEEKITLRNKAKQEKNYVLADQIRDDLAKENILLMDTPNGVVWEKNG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_ONYPE
Sequence: MKFNNKKNTFKKRRKVCFFTENKVTKIDFKDIELLQRFITDRGRILSRRVTNTSAKWQRQLAIAIKRARHMALIPFIQQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TAL_XANAC
Sequence: MTASPSKLAQLRELSVVVADTGDYDAIKRLKPVDCTTNPTLVKKALDLPVYADLIERELAWGREHGGDDRTATVNEVADRLTIGVGVKLAELVPGRVSTEVDADLAHDTQATIAKARKFIAMYAERGVSKDKILIKIAATWEGIEAARQLQKEGIDCNLTLIFNRSQALACAEAGVFLISPFVGRILDYYVAQGQTPASIDEDPGVVFVRTVYNEFKQRGSSTVVMGASFRSTAQIEALAGCDRLTISPDLLEKLDAEHGELPRKLSPAQADNAQFTPIDSDSFASGLAADPMATEKLAGGIDTFAKDLHALRKTIADKLAG
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNK_BACC7
Sequence: MGYYSLTEVTAVQYAKEHGYFEKKANVVCHEIGDGNLNYVFKLDDGEKSIIIKQALPYAKVVGESWPLSIKRATIESKALQIFAKYVPEYVPVVYSHDEELAVTIIEDLSKLTITRKGLIDGEEYPLLSQHIGRFLANVLFYTSDFGLQSEEKRVLEGTFVNPDLCKITEDLVFTDPFGHYDTNDYESELQLAVDELWSDKTLKLKVAQYKYKFLTRKEALIHGDLHTGSIFSSPSETKVIDPEFATYGPFGFDIGQFIANLLLNALSREEEQRSVLFFHIEKTWSYFVDTFTKLWIGEGVEAYTKEKQWLPIILQNIFTDVVGFAGCELIRRTIGLAHVADLDEIANKETRIQAKKQALSLGRELIKYESKNADIQLFRALFQQTVSGGVKA
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: ZFR_HUMAN
Sequence: MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAPAAATVAVARPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYTQAQQTRQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSGTSYSGYEAAVYSAASSYYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKKAPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQTYKEHLEGQKHKKKEAALKASQNTSSSNSSTRGTQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVKLHTKLGKPIPSTEPNVVSQATSSTAVSASKPTASPSSIAANNCTVNTSSVATSSMKGLTTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINFVGGNKLQSTGNKAEDIKGTECVKSTPVTSAVQIPEVKQDTVSEPVTPASLAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKEEYWRRREEEERWRMEMRRYEEDMYWRRMEEEQHHWDDRRRMPDGGYPHGPPGPLGLLGVRPGMPPQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEELQAVQKIVSITERALKLVSDSLSEHEKNKNKEGDDKKEGGKDRALKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPEKYDIKCAVSEAAIILNSCVEPKMQVTITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVLGMDPLPQMSQRFNIHNNRKRRRDSDGVDGFEAEGKKDKKDYDNF
What is the function of this protein?
Involved in postimplantation and gastrulation stages of development.  Involved in the nucleocytoplasmic shuttling of STAU2.  Binds to DNA and RNA (By similarity).
What are the official names of this protein?
Zinc finger RNA-binding protein, hZFR, M-phase phosphoprotein homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic granule. Chromosome. Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity).
Protein: PSBZ_SPIOL
Sequence: MTIAFQLAVFALIATSSILLISVPVVFASPDGWSSNKNIVFSGTSLWLGLVFLVGILNSLIS
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: L2MU_ADECR
Sequence: MAGRNVTLRLRVPVRTKITGAGRRRGRRTRIRCGRMKGGFLPALIPLIAAAIGAVPGIASVALQAARH
What is the function of this protein?
The role of the precursor might be to condense the viral prochromatin for encapsidation by virtue of the two basic domains.
What are the official names of this protein?
Late L2 mu core protein, Protein X, pX, pMu.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae pX family.
What are the subcellular locations of this protein?
Virion.
Protein: RS8_HALOH
Sequence: MNITDPIADMLTRIRNANDTNKDVVNIPASNMKISIARILKEEGYIKDYKVIEKKPQNALRIYLKYSKNGEKVISGLKRISKPGLRVYVKKDEVPKVLGGLGIAVLSTSRGILTDKQARQEGIGGEVLCYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: Y4551_DICDI
Sequence: MLNIQPTQSIVNNQPKSDQKKQKPADLLKEFYDKTGNRN
What are the official names of this protein?
Uncharacterized protein DDB_G0281597.
Protein: RNY_SYNWW
Sequence: MIEIDLTSFVIITLSLAVGLTGGYYGRRFLAESRIRTAEEEVAKMLDEAAKEVEAKKKEILLEAKDEIHRNRQDAEKDIRERRRELDRVERRIIQKEEMIDKKTENMEKKEQVLLEKEKETEKTQQDLQMVLSQQLKELERLSGLSSEEAKELLLYNVSQQIRQETAVLIRNIENEAKEEADKKAKNIVSLAIQKCAADVVSESTVSVVPLPNDEMKGRIIGREGRNIRTFEALSGVDLIIDDTPEAVILSSFDPIRREVARVALGNLVSDGRIHPARIEEMVEKARKEIEQEIREVGEQAAFEVGVHGLHPELIKLLGRLKYRTSYGQNVLRHSVEVAHLAGIMAAELEVDIMLAKRSGLLHDIGKAVDHEVSGPHVEIGVDLAKKYRENKDVIHGIEAHHGDIEPETVEAVLVQAADAISASRPGARRETLETYIKRLEKLENVAESFSGVDRTFAIQAGREIRIIVKPEEIDDLHSINLARDIAAKIEQDLDYPGQIKVVVIRETRSVEYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: T2FB_SCHPO
Sequence: MSEEKPTVRTEEDDRYEDDAGDLDLGQIGSRVWLVKIPKFLMDKWNSIPEDDAANLGCVRVKNDEIQLLLQNSPENADVPKIYNLRVMNKFVRNSYVFRESETSSSMKSTALVGTVAHECNVSPVINDDYRRVMQKRALAASAPKRKVQMIDDRGGSLLAPGTLGSRSRSTTSFIRNVKPRTGEGLKNSRIPRNELLDILFKCFEDYEYWTLKGLREYVKQPEVYLKEVLDSIAILNKRGPYALKYSLKPEYKGTMDAASVELRNQQASQSESSSIDHTGKNTSPDNPGTNAEEDEDDDGVEMIDVV
What is the function of this protein?
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.  It promotes transcription elongation (By similarity).
What are the official names of this protein?
Transcription initiation factor IIF subunit beta, TFIIF medium subunit, TFIIF-beta.
What is the protein family that this protein belongs to?
Belongs to the TFIIF beta subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ALDC_LACLM
Sequence: MSEITQLFQYNTLGALMAGLYEGTMTIGELLKHGDLGIGTLDSIDGELIVLDGKAYQAKGDKTIVELTDDIKVPYAAVVPHQAEVVFKQKFTVSDKELEDRIESYFDGQNLFRSIKITGKFPKMHVRMIPRAKSGTKFVEVSQNQPEYTEENIKGTIVGIWTPEMFHGVSVAGYHLHFISEDFTFGGHVLDFIIDNGTVEIGAIDQLNQSFPVQDRKFLFADLDIEALKKDIDVAE
What is the function of this protein?
Converts acetolactate into acetoin.
What are the official names of this protein?
Alpha-acetolactate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the alpha-acetolactate decarboxylase family.
Protein: RECR_XANCP
Sequence: MSSLLEQLIEAFRVLPGVGQKSAQRMAYHVLEREREGGRRLAAALANAVEKVGHCVQCRDFTESEVCAICANSGRDRQQLCVVESPADRLAIEHATGYRGVYFILQGRLSPLDGIGPRELGLDRLAERLAAGEVTEMIIATNATVEGEATAHYLAQLARQHSVRPSRLAQGMPLGGELEYVDRGTLSHAFGTRSEVL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: DDX47_DROME
Sequence: MSETSEDEQTQLQTSDEEEDLGSEEEQEDEDNNHKEGDSEAALSGEDDKGSEDDAAEEQKLTWKDLGLNEALCQACDELKWKAPSKIQREAIPVALQGKDVIGLAETGSGKTGAFALPILHALLENPQRYFALVLTPTRELAFQIGEQFEALGSGIGIKCCVVVGGMDMVAQGLQLAKKPHIIIATPGRLVDHLENMKGFNLKAIKYLVMDEADRILNMDFEVELDKILKVLPRERRTFLFSATMTKKVKKLQRASLKDPVKVEVSNKYQTVEQLQQSYLFIPVKYKDVYLVHILNELAGNSFMIFCSTCNNTVKTALMLRALGLAAIPLHGQMSQNKRLAALNKFKAKNRSILISTDVASRGLDIPHVDVVVNFDIPTHSKDYIHRVGRTARAGRSGKAITLVSQYDIELYQRIEHLLGKQLTLYKCEEDEVMALQERVAEAQRTAKLELKDLEDTRGGHKRGGDTHDDSENFTGARKRMKPMGGTGGGGRKSFGKKNWSKGKQKR
What is the function of this protein?
Part of a translational control module, also containing ath/DHX33 and ais/DDX52, which coordinates germline stem cell differentiation with ribosome biogenesis during oogenesis.  This module allows for coregulation of ribosomal proteins and non1/GTPBP4, a p53 repressor, preventing p53 stabilization, cell cycle arrest and loss of stem cell differentiation (PubMed:35413237).  With atos, adjusts transcription and translation of a subset of OXPHOS genes in marophages to increase mitochondrial bioenergetics and allow tissue invasion (PubMed:35319107).
What are the official names of this protein?
ATP-dependent RNA helicase DDX47, DEAD box protein 47 homolog, Protein porthos.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
Protein: TRMJ_SALTY
Sequence: MLQNIRIVLVETSHTGNMGSVARAMKTMGLTNLWLVNPLVKPDSQAIALAAGASDVIGNAQIVDTLDEALAGCSLVVGTSARSRTLPWPMLDPRECGLKSVAEAANTPVALVFGRERVGLTNDELQKCHYHVAIAANPEYSSLNLAMAVQVIAYEVRMAWLATQENGDAADHEETPYPLVDDLERFYGHLEQTLLSTGFIRENHPGQVMNKLRRLFTRARPESQELNILRGILASIEQQNKGK
What is the function of this protein?
Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
What are the official names of this protein?
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ, tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase, tRNA Cm32/Um32 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_CHLAA
Sequence: MLTRRIIPCLDVKAGRVVKGVKFLNHRDAGDPVELAAAYNAAGADELVFYDITASSDERAIMVEVVERTAAEVFIPLTVGGGLRSVDDMYRMLRAGADKVSLNTAAVYNPQLIAEGARRFGSQCIVLSVDAKRVNAPGEPPRWEVFTHTGANPRPTGLDAIEWIKRGIDLGAGEICINSMDADGARTGYDLELLQAITAISPVPVIASGGVGSPHDMYRGIVEGGADAVLAASIFHFGDYSVADVKRYLAERGVAVRMI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_PROMA
Sequence: MATPAKKTGSKKSKRNVPNGVVHIQSTFNNTIVSITDTNGEVISWSSAGASGFKGARKGTPFAAQTAAEAAARRALDQGMRQIEVLVRGPGSGRETAIRALQVAGLEITLIRDVTPLPHNGCRRAKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: OEP80_PEA
Sequence: VLISEVLVRNKLQVSEAEVNNISIRFLDRKSIVPQPAQTAVDLIVRGLIGSFAYSHRLNLSLERTPGTLVHGNQDGNSNLTIGRWSGTAGLIFQRYNSPLTASGNTHTETLLAKSATLELTDEQGLPVLSFAEVMQKCVNTHRSYVVGSVDSPLGPLR
What are the official names of this protein?
Outer envelope protein 80, chloroplastic, Chloroplastic outer envelope protein of 80 kDa, PsOEP80.
What is the protein family that this protein belongs to?
Belongs to the OEP80 (TC 1.B.33.2) family.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane.
Protein: ITPA_BATDJ
Sequence: MQSVVFVTGNANKLREVQDIVGNALPMLTCHQLDLPELQGTTQTVSIHKAKTAAAILKTPVLIEDTSLGFVALNGLPGPYIKWFMESVGHVGLNAMLHGFDDKSAFALCTFAYCEPGHDPILFEGRTDGLIVHPRGPAGFGWDPIFQPCGFTTTYAEMDKDLKNSISHRYKALALVKEFFQSKSDLALHS
What is the function of this protein?
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives.  The enzyme does not distinguish between the deoxy- and ribose forms.  Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine triphosphate pyrophosphatase, ITPase, Inosine triphosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SSR2_CANLF
Sequence: MDMEYELLNESHTWVSPPFDLDGSVVAANSSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIAGELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMVNVAVWGVSLLVVLPIMIYAGLRSNQWGRSSCTINWPGESGTWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDLVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGPDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
What is the function of this protein?
Receptor for somatostatin-14 and -28.  This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.  In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins.  Inhibits calcium entry by suppressing voltage-dependent calcium channels.  Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion.  Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B.  Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development.  Mediates negative regulation of insulin receptor signaling through PTPN6.  Inactivates SSTR3 receptor function following heterodimerization (By similarity).
What are the official names of this protein?
Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm (By similarity).
Protein: EFTS_RICPR
Sequence: MSEINISAVVVKELREKTGAGMMDCKKALIETSGNFEEAIDFLRKKGLAAAVKKSGRIASEGLTAVKVDGLISAVIEVNSETDFVARNKQFQDLVKDIVNLAIIAQNIDTLKISKMQSGKSVEEEIIDNIAIIGENLTLRRMDILEISNGAIGSYVHNEVVPHLGKISVLVGLESNAKDKVKLEALAKQIAVHVAGNNPQSIDTLSLDKSLIEREKKVFFEKSKEEGKPNHIIEKMVEGRIRKFFSEVVLLHQNFLFEPKLTVAEVIKNAEQELSAEIKITKFIRYALGEGIEHAEKNFADEVAAITQC
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYIN_PSESS
Sequence: MHEIITLESLCQALADGEIAAAELRERALDTEARLARLNCFIREGDAVSQFGEADHAMKGTPLWGMPVSFKDNICVRGLPLTAGTRGMSGFVSDQDAAIVSQLRALGAVVAGKNNMHELSFGVTSINPHWGTVGNPVAPGYCAGGSSGGSAAAVASGIVPLSVGTDTGGSIRIPAAFCGITGFRPTTGRWSTAGIIPVSHTKDCVGLLTRTAGDAGFLYGLLSGKQQSFPLSRTAPCRIGLPVSMWSDLDGEVERACVNALSLLRKTGFEFIEIDDADIVELNQTLTFTVPLYEFFADLAQSLLSLGWKHGIHHIFAQVDDANVKGIINHHLGEGAIKPAHYLSSLQNGELLKRKMDELFARHNIELLGYPTVPCRVPHLDHADRPEFFSQAIRNTDLASNAMLPSITIPVGPEGRLPVGLSFDALRGRDALLLSRVSAIEQVLGFVRKVLPHTT
What is the function of this protein?
Hydrolyzes indole-3-acetamide (IAM) into indole-3-acetic acid (IAA).
What are the official names of this protein?
Indoleacetamide hydrolase, IAH, Indole-3-acetamide hydrolase.
What is the protein family that this protein belongs to?
Belongs to the amidase family.
Protein: FOCAD_MOUSE
Sequence: MSDDIKKRFDFPNSLIQSQAVGHLIAAVLKEHGVSEKIHQSTNQTAALNLLWEKCCSDHVVVRTACSEGLVALVAQGHAEFSYVLNGILNLTPSARNMSGLIKALMKLLQMQALREGQSGEKDIQDIYSIRNPPQPLITVLEHRPDCWPLLLQQLTAFFQQCPERSEASCVQIMAPFLWYLYCEPSQLEEYAKLRLSLLKVLLQPRGVCEEAQLSVREQSTLQLCCSMLPCLQMKDLMQTTEMMLFVEEVYLSLLRHPGFWKSQLTQLTLQLLCICEVSLKITGECSSLIHLLERSVELLGEDFPVELVIIGIALLLLQMPASQQKPLLNLALKLLSLTEGQKIPKASLLLLVPLLQILSSTALEDCLAMGEEGPSRQQLALSLVEVLQKERHGDDSHTISCRLAFPVSSMYGSIFTAWRILDVIGEESATSDWLATVESLLSATTVIPPHVFLLLAYLLVEDVGQNLQQILRVTTQLAQADSSQVPNLIPVLMFKLGRPLDPVSYNHILYTLPTLGVHKVCVGQILRVIQLLGTTPRLRAVTLRLLTSLWEKQDRVYPELQRFMAVSDAPSLSVGKELQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQATPAALVLQGLHALCQAEVVCIRSTWNALSPKLSCDMRPLILKTLSELFSLVPSLTVNTVEYENFKVQVLSFLWTHTQNKNPTVASAAYKSLSHFSAGEHTILHLPEKIRPEMPVPGELDEEESVDLSIPGACFLRLLTITAPSVLPALEEFFTSLVRQEMVNMPRGIYHSALKGGVRSDQGKTVAGIPNFILKTYETNKQPGLKPGLAGGMLFCYDLAMYQSKDGKPLNRLMASRGRSFKQTTLALIHEVHVQLSEWHRAIFLPQAWLAYMTRAYHAILQGRIAELELQLQHGKEGPEEVQYKRSTAWLWVRDMLTDEITKTAAKESPVVKANALLALSSLAVVVSKHEASLCSDSDGVLEIQPNFLPVKEWVSMVLNTLLVIVDSHYHPSGQLFTCFYHKSYSGENTASAIARSAAATALSLLVPVFIISCKEKVEEILNMLTARLPGKPSADESQAVQIHMGLALGMFLSRLCEEKLSDMSGQQMNLLLMKSLDALESCCFDPSLEYNTGCILGVGLALSLMSHSSHTESRVHVAASLRKLSTYLDESGSQSRTFQEVLVYTLSCVCTSAFSAGIIEAAEAEDIMSKLQLLVENNQQTSGFALALGNLVYGLSVCGHGKAEDLGNRLRPSWIKVVLTEGAPTMLCLAALHGLVALVGSDVDVMQLKSEAIQNTHFQARLNEVIRTLTEVISVSGVIGLQSNAIWLLGHLHLSTLSSNQSRTSVPTDYSYLPEGSFIRAAIGFFITGGKKGPEAVPPSLLKVVMKPIATVGESYQYPPANLAALLSPLMRLNFGEEIQQLCLEIAVTQAPSSQSAASLLGLWVMPPLIHGLSLNIKKYLLVSMPLWAKHVSDEQIQGFVENLMVEVFKTASQPCHPEMCLSALQGLSQAMKLPSPSHHLWSLLCDATGRIFDLLPNRIRRNDLELYISIAKCLSEMTDEGVNQVSQITKDNIEKAAFVKLYLVSQGRLPLMSLTDLLTAAMQHPEKETLAWMILHSLYQARIVNHANTGVLKRLEWLLELMGYVRNIAYQSAPIQNVAPEEALDFLMLIFAAAVVAWADHEAPLLLGLSASWLPWHQQNGPGGPAAALLGRSPMHRVTVQEVLTQLPRSMLLLLQKEPWKEQTQKFIDWLLSIMEIPNKAFAAKSKDLLKATLLSLRVLPEFKKKAVWTRAYGW
What is the function of this protein?
Required for the maintenance of SKIC2 and SKIC3 proteostatic levels in the liver.  May be involved in the regulation of RNA degradation by the exosome complex (By similarity).  Potential tumor suppressor in gliomas.
What are the official names of this protein?
Focadhesin.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell junction, focal adhesion. Note=Colocalizes with VCL in astrocytes.
Protein: PYTF_ASPTN
Sequence: MTTKEAIADMALEAQEEDDAGPPDGGFRAWLVVLGGFLAYFVTFGMLNSFGTFQEYYGEKLLPGRSTSEISWIGSLQLFLLFIGGLFFGPVFDAKGSKVLFIPGTLLLSLSQMMVSLCKEYYQFILAQSLLFGIAVAMLFYPTISAISHWFHHRRGLAMGIVLTGSSLGGIAWPLILERLFAVVGFPWGLRIVGFISFALLAPACFMVIPRLPPRKSGGLSKADLSEGLKDRRYWLTVVGMLFVIWGMFIPFYYIPLFAMDHGVNSSFANSLISILNAGSFVGRIVSGALADKLGR
What is the function of this protein?
MFS-type transporter; part of the gene cluster that mediates the biosynthesis of pyranterreones, a family of antioxidative compounds (PubMed:32077283).  Directly involved in the secretion of pyranterreones (PubMed:32077283).
What are the official names of this protein?
MFS-type transporter pytF, Pyranterreones biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RT10_YEAST
Sequence: MLRNTIALRSFIRTQSTRPYPVNVEAVYYAPLKLPIKYGDLVADIQLRSYDNENLDFYSDFILRTGYYLGIPLTGPKPLPTRRERWTVIKSPFVHAKSKENFERHTHKRLIRAWDTNPEVLQMLIAYITKHSMAGVGMKCNFFQRSEISLDLGSDANGLEKSLSNIDELYSLRNDDKAQTSAVGQKVLELLDSPDFKKHLEKK
What is the function of this protein?
Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.  The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
What are the official names of this protein?
37S ribosomal protein S10, mitochondrial, Mitochondrial small ribosomal subunit protein uS10m.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
What are the subcellular locations of this protein?
Mitochondrion. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1.