PharMolix/UniProtQA huggingface dataset:
Protein: TRPA_OCEIH
Sequence: MGKSKLDAVLKEKTQAKKPIFVPYIMAGDGGIDNLNKRIQFLEEAGASAVELGIPFSDPVADGPVIQDAGQRALANKTTIGSVLEALESEKSQRNIPVVLMTYINPVWKYGFEQFARDCSQAGVDGIIIPDIPMEEEDDVASSLTQHDIAFIRLAAMTSTEDRLERIAKRSEGFLYAVSVTGTTGERAQHENDAFHFLEKLKQISHVPVLAGFGISTAERARELSAACDGVVVGSKIVQLFEQGDEDGIHSLIRESIGEKVI
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: BCHN_RHOP5
Sequence: MNARAEGCTAAPDPSSRVVRHERGQHEVFCGLTGIVWLHRKIQDAFFLVVGSRTCAHLIQSAAGVMIFAEPRFGTAIMEEKDLAGLTDANDELDRIVTQLIARRPDIKLLFLVGSCPSEVIKLDLSRAALRLSQRFSPAVRVLSYSGSGLETTFTQGEDACLASLVPVLPASTGTEASLLVVGSLADVVEDQFIRLFDGLGIGSVQFFPPRNSGSMPSVGPNTKFLLAQPFLPDTARELEHRGAKRLAAPFPLGVEGTTGWLRAAANAFGVDEALFDKVTQPARVRAERALDKFRKELSGRRLFFFPDSQLEIPLARFLSRELSMELVEVGTPYLHREHLAEELKLLPADAAITEGQDVDLQLDRCREARPDIVVCGLGLANPLEAEGMTTKWAIELVFTPIQGYDQASDLAELFARPLVRRAKLVA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
Protein: UREG_RALPJ
Sequence: MRTKKLPALRVGVGGPVGSGKTTLLEMLCKAMRERYDLVAITNDIYTKEDQRLLTISGALPAERIMGVETGGCPHTAIREDASINLEAVDRMLAKFPDADVVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLIINKTDLAPYVGASLEVMESDTRKMRGDRPFVMCNLRAQGGLDEVIRFIERQGMLAA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYPR_CANLF
Sequence: MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTIVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
What is the function of this protein?
This is the major myelin protein from the central nervous system.  It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
What are the official names of this protein?
Myelin proteolipid protein, PLP, Lipophilin.
What is the protein family that this protein belongs to?
Belongs to the myelin proteolipid protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Myelin membrane. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt- Lanterman incisures of myelin sheat.
Protein: GDIB_PONAB
Sequence: MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRYKIPGSPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESLIFISRTYDATTHFETTCDDIKNIYKRMTGSEFDFEEMKRKKNDIYGED
What is the function of this protein?
GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins.  By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking.  Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A.
What are the official names of this protein?
Rab GDP dissociation inhibitor beta, Rab GDI beta, Guanosine diphosphate dissociation inhibitor 2, GDI-2.
What is the protein family that this protein belongs to?
Belongs to the Rab GDI family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: TRUD_METMA
Sequence: MEVPEIEKQIGINLYSTDTTGLGGQLRQEIEDFIVKEITNREEGEEGKYLIVELTKRDWDTHHLTRTLSRILQVSQKRISVAGTKDKRALTTQKISIFDTDASEIEKIHLKDIELKVLGRSRKSVELGDLWGNDFRITVRNIENSPEETEALLKKTTDEILAQGGVPNFFGIQRFGSVRPVTHLVGKAIVEGNFEKAALLYIAEPFPEEPEETKNARQFVKDTLDFKEGLKTYPLRLGHERAMMNHLIANPEDYSGSFRVLPQNLYRMFVHGYQSYIYNIILCRRIEAGIPLNRAVEGDIVCFRNEVGLPDSSKTEKVTSETVNAMNRLLKLGRAFITAPLPGYNTEFASGIPGEIENGVLKELGVSLEGFNIEKFPEMSSKGTRREVLLEVKPKFEAGEDELNPGKSKAVLEFMLPKGSYATTVLREYMKVNPLQMS
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: HCHA_STAA1
Sequence: MSQDVNELSKQPTPDKAEDNAFFPSPYSLSQYTAPKTDFDGVEHKGAYKDGKWKVLMIAAEERYVLLENGKMFSTGNHPVEMLLPLHHLMEAGFDVDVATLSGYPVKLELWAMPTEDEAVISTYNKLKEKLKQPKKLADVIKNELGPDSDYLSVFIPGGHAAVVGISESEDVQQTLDWALDNDRFIVTLCHGPAALLSAGLNREKSPLEGYSVCVFPDSLDEGANIEIGYLPGRLKWLVADLLTKQGLKVVNDDMTGRTLKDRKLLTGDSPLASNELGKLAVNEMLNAIQNK
What is the function of this protein?
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals.  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE).  Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA.  Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair.  Plays an important role in protecting cells from carbonyl stress.
What are the official names of this protein?
Protein/nucleic acid deglycase HchA, Maillard deglycase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family. HchA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S35F5_MOUSE
Sequence: MVPPRLHRGAGRPGGLSSLPPFGLGSARFAGIAFEDLREALATRLQMVYVFIMNRVNSQSSGFSQRRRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIIWKPWRQQCTRGFRGKPAAFFADAEGYFAACTTDTSMSSSLSEPLYVPVKFHDLPSEKLESTNIGTEKTPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPTVKDQESILKTVGKLTATQVAKISFFFCFVWFLANLSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVILSIGGVVLVNLSGSEKSAGRDTIGSIWSLAGAMFYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLLCIIINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIVTLLCHYNNWDPVMVGVRRVFAFICRKHRIQRVPEDSEQCESLISMHSVSQEDGAT
What is the function of this protein?
Putative solute transporter.
What are the official names of this protein?
Solute carrier family 35 member F5.
What is the protein family that this protein belongs to?
Belongs to the SLC35F solute transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IFT22_HUMAN
Sequence: MLKAKILFVGPCESGKTVLANFLTESSDITEYSPTQGVRILEFENPHVTSNNKGTGCEFELWDCGGDAKFESCWPALMKDAHGVVIVFNADIPSHRKEMEMWYSCFVQQPSLQDTQCMLIAHHKPGSGDDKGSLSLSPPLNKLKLVHSNLEDDPEEIRMEFIKYLKSIINSMSESRDREEMSIMT
What is the function of this protein?
Small GTPase-like component of the intraflagellar transport (IFT) complex B.
What are the official names of this protein?
Intraflagellar transport protein 22 homolog, Rab-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: PROB_BACCZ
Sequence: MKKQRIVVKIGSSSLADSHEGISKEQLSDHVAALARLKEEGHEVLLITSGAVAAGFSALGYPSRPVTIKGKQAAAAVGQSLLMQAYTEEFRKYGIVTAQLLLTRSDFSRKEQYSNAYATLGELLNRSALPIINENDSISLEELTFGDNDMLSALVSGLVSADMLMIFTDVNGLYDKNPQKNEDAKKYYFLPEVTEEIASLAGDAGSKLGTGGMKSKVDAAKTALSLGVSVFIGTGRGQEKFVDVLKGKGDGTYVGNAPQKEMKMNKQWIALHSVVSGQIEIDAGAATAIIQHGKSLLPAGVTNVSGFFQVGEVVEVMTQQGRVIGKGQCTYSAEELRDVKGMQSQHIQARGERHSYEVIHRDHWVSL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1421_MYCTO
Sequence: MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGRE
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein MT1464.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: FLPA_METM6
Sequence: MEKIKVREIFNNAYSVDFGDGLKRIATKSLVPGKRVYGEKLVYSDNIEYRVWNPNKSKLGAAIINGLKKMPIKKGTKVLYLGASAGTTPSHVADIAETSLVYALEFAPRIMREFIDSCNERKNLIPVLGDANRPQDYSNIVEKVDVIFEDVAQPNQAEILVKNAKWFLKENGYAMISIKARSVDVTKNPREIFAEQKKILIEGGFEIVDEVNIEPFEKDHMMMVGIWKGN
What is the function of this protein?
Involved in pre-rRNA and tRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
What are the official names of this protein?
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
Protein: TRUA_STRP8
Sequence: MVRYKATISYDGTLFSGFQRQRHLRTVQEEIEKTLYKLNNGTKIIIHGAGRTDAGVHAYGQVIHFDLPQEQEVEKLRFALDTQTPEDIDVVNIEKVADDFHCRYQKHLKTYEFLVDNGRPKNPMMRHYTTHYPYTLNIKLMQEAINGLVGTHDFTGFTAAGTSVQNKVRTITKATVSRDEKTDFLVFTFSGNGFLYKQVRNMVGTLLKIGNGQMPVEQVKVILSSKNRQLAGPTISGNGLYLKEICYEN
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: NDHK_ORYSI
Sequence: MSLIEFPLLDQTSSNSVISTTLKDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDALTKLRKKISREIVEDRTLSQKKNRCFTTSHKLYVRRSTNTGTYEQELLYQSPSTLDISSETFFKSKSPVSSYKLVN
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, chloroplastic, NAD(P)H dehydrogenase subunit K, NADH-plastoquinone oxidoreductase subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: CHO2_ASPFC
Sequence: MDRGLSTGAHQADDGLRERTVASQSSSAPGLEALTATGEGEVKDKAGKGKKTYGRTPQGKVFTVPQTHDMVSQLLSPSEPKNLSDVIVLAILAAHILLLWRLPAGVKVPVFAFIYLFWRGAYNAGIGWLLHNQSNHRTLVRWAEKTKIFVNPATGQNPHANLYKLIKRELETKIPADYSFEDAPIEYNTWLVFRRLVDLILMCDFTSYCLFAIACSQRPFDEGTLMTVLRWSAGIVLVLFNLWVKLDAHRVVKDYAWYWGDFFFLIDQELTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKVLFISILAHAAQFAFLVFVENPHIEKTYNPPPPRKRTIEQENVSITPQRSDSPSAPASVDEQVPHAPSYSSGPPPSVHNLLGFRNLDLYRTIDTSSILIQFLVFALTVLTPSTPWFQFLFVANAAVWRIWYSVGIGFVLNRQSNCKAWTRHFVKYGESPQEAWNQWKGTYHISMVMCYASFIAAVWKMYSFPADWGYGLVLLRHVLGAGLIALQIWTSVSIYESLGEFGWFYGDFFFDESPKLTYDGIYRFLNNPERVLGLAGVWGAVLITSSGAVTFLALMSHILSLGFIQFVERPHMQKLYGRSLRRDAGLTKSLKRSLPPSLQQLHGSVDKIFDESFEFIEELIDTARPKLAAGVNTFVKDTSALFQKYPARVTISRIDEDLAGYDLRDYSLEIEGTDSLSPNDNDQSGREGANARMPLDRRGDLKNLVFEYGSPIKVKWTAPLNHSKKDWIGLYRVTDNTSREVTRVSSQGRWIAVNEGSYDNLTCEKGIVSSDILIPASQRKDNENRDLASGEVIFSGDKLFWTQGVFEFRYHHNGKHNVMAISRPFEIRISRFDEDEIPLMNPTSVELSLFPVVRNCLDRDPQIAPETVDEPFGGLVERDGKYAKRVVFAVHQM
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YCF4_LOLPR
Sequence: MNWRSEHVWVELLKGSRKRGNFFWACILFLGSLGFLSVGASSYLGKNIISILPSQQILFFPQGVVMSFYGIAGLFISSYLWCTILWNVGSGYDRFDRKEGIVCIFRWGFPGIKRRVFLQFLMRDIQSIRIQVKEGLSPRRILYMEIRGQGVIPLTRTDEKFFTPREMEQKAAELAYFLRVPIEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NUBP1_DROPE
Sequence: MQAPPPEHCPGVESEQAGQVSACAGCPNQSICSDPNKKREDPGKALVAAALKDVKHKLLILSGKGGVGKSTVTTLLTRYLARSYPDSNFGVLDIDICGPSQPRLMGALGENVHQSGSGWSPVGIDDNVCLMSIGFLLGSVDDAIIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLKDDSAPDSVHAIIVTTPQEVALLDVRKEINFCKKQQIPIVGVIENMSGFRCGHCGHSSEIFPAKTGGAAAMCAEMEVPLLGSLPLDPAIAKACDAGEDITSVKNPTTEALEGICSKIMSSFN
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NUBP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAC_EUCGG
Sequence: MSHSVKIYDTCIGCTQCVRACPTDVLEMIPWDGCKAKQIASAPRTEDCVGCKRCESACPTDFLSVRVYLWHETTRSMGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: UDG_RICPR
Sequence: MNITFIGSGYVGLVSGIIMGYLGHNVTCLDNDDVKISKLNKKILPIYEAKLDEYLKHALESDRLKFTNIYSNEFRNFDAIFITVGTPSKELGEADLKYVYDAVDKVSKHINKDCLIVIKSTVPPGSCNNIIAYLKAKGFSFNVASNPEFLREGSAVEDFLYPDRIVVGVNNKESEALLRKIYAPLIEQGAKFLVTNLVTSELIKYVSNSFLATKIAFINEMADLCEKIGANIKDLSQGVGLDQRIGRNFLNAGPGFGGSCFPKDILALNNLVENHKIDCKILKSVIKSNKLRPSNMVAKIATLLDGDLKGRNIAILGLTYKAGTDDVRASPAIEIITILLNKDVYVKAFDPIGLENAKKNLEHKNLLYFASAVEACKSVDIIVIATEWSEFKELNWQEIYNLVKSPMIIDLRNILDNEVMKKIGFRYYAVGSQI
What are the official names of this protein?
UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH.
What is the protein family that this protein belongs to?
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
Protein: KGUA_TRIEI
Sequence: MQTGKLIVLTGPSGVGKGTLLSCLLHRHPGLAFSVSVTTRSPRPGEVEGKSYFFVDHDQFREMIESEELLEWAEYAGNFYGTPRVPVIENIEQGRSMILEIELQGARQIQRTFPDALRIFILPPSMAELEERLWGRGQDSEEAITKRLQRATEELEAATEFDIQLVNDSIEDTLQNLDKILFHFRE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NORR_SALHS
Sequence: MSFSVEVLAGIAIELQRGIGHQDRFQRLITTLRQVLACDASALLRYESRQFIPLAIDGLAQDVLGRRFTLEGHPRLEAIARAGDVVRFPADSDLPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDAMTPEQFEVFSDEELRLVAALAAGALSNALLIEQLESQNMLPGSSGVFEPIKETHMIGLSPAMTQLKKEIEIVAGSDLNVLIGGETGTGKELVAKAIHQGSPRAVNPLVYLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLFVPPLHERGDDVVLLAGYFCEQCRLRLGLSRVVLSPDARRHLLNYGWPGNVRELEHAIHRAVVLARATRAGDEVVLEAQHFALSEDVLPAPPAESFLALPACRNLRESTENFQREMIRQALAQNNHNWAASARALETDVANLHRLAKRLGLKD
What is the function of this protein?
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon.  Activation also requires sigma-54.
What are the official names of this protein?
Anaerobic nitric oxide reductase transcription regulator NorR.
Protein: PDXT_GEOKA
Sequence: MKIGVLGLQGAVREHVRAIEACGAEAVIVKKPEQLEGLDGLVLPGGESTTMRRLIDRYGLMEPLKQFAAAGKPMFGTCAGLILLAKRIVGYDEPHLGLMDITVERNSFGRQRESFEAELSIKGVGDGFVGVFIRAPHIVEAGDGVDVLATYNDRIVAARQGQFLGCSFHPELTDDHRLMQYFLNMVKEAKMASSLK
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: HRCA_DEHMB
Sequence: MLTSRAEIILRSIVRQYITKAVPVSSSSILEDCGLDICSATIRNEVVRLEIEGYILRPHHSAGSIPADKGYRYYVESLKDVELPTNDKFLIRHLFHQVEKEMEEWLNLTVAVLSQRVQSMAVVTMPRQTQGKVHHIELVSLQDNLVLVVLILRGAKVKQQLVNFENVVSQPELTLISNRLNDAYDGLTRFQIEQKPLGLNHDELKVKDSLVKMMRGEDEQESREPFFDGLHYMLEQPEFHQNQRAQEIMQLLEQKKLSKMIVPPMPFNRGVQVYIGQENASAEIRDYSLIVSQYGIPDEAVGTIGVIGPTRMAYERALSAVSYLSLVMSTLVAELYGKAPVDKDE
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RRF2M_ASPNC
Sequence: MVTALFLRASHQTVRPTGLRQCQAAASRLGCNASLIPGVKKGQFPKIQMLSTSASKLQADTLDRTRNIGIIAHIDAGKTTTTERMLYYSGFTRRIGDVDEGSTVTDFLPAERARGITIQSAAITFHWPPQAAVNLIDTPGHADFTFEVMRSLRILDGAVCILDGVAGVEAQTERVWHQASTYRIPRIVYINKLDRDGAAFGRTVREISSRLAGYPAVCQVPWFEGGNGRFVGVGDAINLQGLRWQDGDGKAVKMFNLQELDGEEPGLAQEIKRARTALVELLSEHDETMIEKFFEHDEDHLAVPPNDILDSLRRCLLQEQGRKIIPIFAGASFRNIGVQPLLDAVTNLLPSPLETPDAEKKSVTQAESQNAIEKLQSCALAFKVVNDAKRGVLVYVRVYSGSLDRNSAIFNTNLKITERAPRLLKMYANDAVEVDSIPEGHIGVVAGLKHARTGDTLVSYAGNKLTPPEPLDTLQLRPIQVPPPVFFASIEPHSLSEEKKIHECLALLLREDPSLHVTVDEDSGQTLLSGMGELHLEIARDRLINDLKAKATMGRIEIGYRECPLGESPVVTKMFDKEIAGRKGKAGCTAVVEPFDPDNAPPVPEDALSVETKEGNQIIIIAPELQVETNRKGIEESPVLPPGLDMQSFRASLHNGCLAALARGPQFTFPMHHTRVTLTINPTEHLFGTDTTPAALSSAARLATSAALRDLLSSGPGTSLMEPVMNVIISIDEASLGAVVHDISSSRGGHIVSLDEEIPLTSTDLSASPQPVEDLPPIDPKKVYAPADPFESGSVGASLPDTANRPRTITAKVPLKEMVGYLKHLRSLSAGHGTFVMSVDRFEKMSTPRQKAVLTELRGGF
What is the function of this protein?
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.  Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
What are the official names of this protein?
Ribosome-releasing factor 2, mitochondrial, RRF2mt, Elongation factor G 2, mitochondrial, EF-G2mt, mEF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SPG4_CANGA
Sequence: MPSFWDSFAVYNRNKHAKGDVHGGHMSQNMGGQPMYLQAKEHADIKKKEDGTLEAKIETPDGPRLVDVSNMTQQEFERTYNSLRKGEPNNRVNF
What is the function of this protein?
Stationary phase-essential protein not required for growth on nonfermentable carbon sources.
What are the official names of this protein?
Stationary phase protein 4.
What is the protein family that this protein belongs to?
Belongs to the SPG4 family.
Protein: ACDD_ASPCN
Sequence: MAPSSNHKVVIVGAGPVGSLAALYAAARGDEVEVYELRGDLRDPSTIPLNFTKSINLALSERGINAMKHTRRDNMIQKILGEAIPVYGRMIHGRNDEKLWEASQAYDVHGRHINAADRCHLNNALLDELEQTPNVKLFFNHKLTGADFRAKKAWFEQRTPADNTSRAPEVEITFDYLVGADGAHSISRYHMMKYARVDYQQQYIDALWCEFHIPPTEEGEFRISPNHLHIWPGKEFMFIALPSADKSFTCTLFASTSYYTLLESSPESLLESFDKNFPGVCPDLITPADLQTQFETNPHLPLISIKCSPYHFGSSAVIVGDAAHAVVPFYGQGLNAGLEDIRVLFECLDQHGVYDLNASPESRALSRQAALQAYTDQRTKDAHAINDLSKDNYIEMRWGVQLPLYKLRKSLEETLDRYMPSLGWQTQYVRVSFSTQPYSEVIKAVERQGTLLLYGSISAIISSAAIVGVLAWNYPMRVSLLSMLQSPIQQLWSVWRNYHC
What is the function of this protein?
Indoleamine 2,3-dioxygenase; part of the gene cluster that mediates the biosynthesis of aspcandine, a pyrrolobenzazepine alkaloid (PubMed:35748771).  Initially, the indoleamine 2,3-dioxygenase acdA accepts L-tryptophan and performs the oxidative opening of the indole ring to yield N'-formyl-L-kynurenine, which undergoes the spontaneous deformylation reaction to provide L-kynurenine (PubMed:35748771).  The kynurenine 3-monooxygenase acdD then hydroxylates L-kynurenine to afford 3-hydroxy-L-kynurenine (PubMed:35748771).  3-hydroxy-L-kynurenine is activated by the A domain of the NRPS-PKS acdB and subsequently loaded onto the enzyme (PubMed:35748771).  The KS domain conducts the decarboxylative condensation of the 3-hydroxy-L-kynurenyl and malonyl moieties, and subsequent nucleophilic attacks by the two amino groups would occur nonenzymatically at two distinct positions, achieving the chain release and the construction of the tricyclic system (PubMed:35748771).  Finally, the dehydration reaction completes the biosynthesis to yield aspcandine (PubMed:35748771).
What are the official names of this protein?
Kynurenine 3-monooxygenase acdD, Aspcandine biosynthesis gene cluster protein D, Kynurenine 3-hydroxylase acdD.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.