PharMolix/UniProtQA huggingface dataset:
Protein: ROM1_HUMAN
Sequence: MAPVLPLVLPLQPRIRLAQGLWLLSWLLALAGGVILLCSGHLLVQLRHLGTFLAPSCQFPVLPQAALAAGAVALGTGLVGVGASRASLNAALYPPWRGVLGPLLVAGTAGGGGLLVVGLGLALALPGSLDEALEEGLVTALAHYKDTEVPGHCQAKRLVDELQLRYHCCGRHGYKDWFGVQWVSSRYLDPGDRDVADRIQSNVEGLYLTDGVPFSCCNPHSPRPCLQNRLSDSYAHPLFDPRQPNQNLWAQGCHEVLLEHLQDLAGTLGSMLAVTFLLQALVLLGLRYLQTALEGLGGVIDAGGETQGYLFPSGLKDMLKTAWLQGGVACRPAPEEAPPGEAPPKEDLSEA
What is the function of this protein?
Plays a role in rod outer segment (ROS) morphogenesis (By similarity).  May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity).  Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity).  Involved in the maintenance of the retina outer nuclear layer (By similarity).
What are the official names of this protein?
Rod outer segment membrane protein 1, ROSP1, Tetraspanin-23, Tspan-23.
What is the protein family that this protein belongs to?
Belongs to the PRPH2/ROM1 family.
What are the subcellular locations of this protein?
Photoreceptor inner segment membrane; Multi-pass membrane protein. Photoreceptor outer segment membrane; Multi-pass membrane protein.
Protein: ISPDF_WOLPM
Sequence: MCAKKYKIAALIVAAGVGSRCNSTIPKQYIKLAGKSVLFHTIKRFLANQYIDYIRIAINRDHESFYEKAISLITDTKLLSPVYGGENRQSSVKLGLESLQKINPDFVVIHDACRPFVSDVLIDNLVESMINDQYTGVVPAIEVEDTMSLVSNSFIESTISRGKLRAIQTPQIFNFKELLSCHQSVKEFTDDSSLMVEHKKHVAIIKGEKSNFKLTTKEDINMAKLLFEEPKFRVGAGYDIHKFIKVQNGAESFIKICGVKIEHNMAIEAHSDGDVAIHAIVDAILGALGCGDIGEHFPPSSSEWKDCNSSHFLDFAAKKAKEKGYSVSNLDITIVCEEPKISPYKVEMKKFISKALEIDDEFVNIKATTAEKLGYIGRNEGIAVHASVLLHTNFYWK
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: ANGT_HUMAN
Sequence: MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
What is the function of this protein?
Is a ligand for the G-protein coupled receptor MAS1 (By similarity).  Has vasodilator and antidiuretic effects.  Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).
What are the official names of this protein?
Angiotensinogen, Serpin A8.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS9_SALTI
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRGELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: SODM_MYCSM
Sequence: MAEYTLPDLDYDYGALEPHISGQINELHHSKHHATYVKGVNDAIAKLEEARANGDHAAIFLNEKNLAFHLGGHINHSIWWKNLSPNGGDKPTGELAAAIDDQFGSFDKFQAQFTAAANGLQGSGWAVLGYDSLGGRLLTFQLYDQQANVPLGIIPLLQVDMWEHAFYLQYKNVKADYVKAFWNVVNWDDVQNRFAAATSKTSGLIFG
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Secreted. Note=Partially secreted.
Protein: FEAS1_HUMAN
Sequence: MDILPYLHMSHGKCPLLVRGKGEMEGEALLSCLAMNSLGEQEACLDLGSKTPSLEISSNNQERPTNREETGIICPERLFIYSSKDSSKRLPGGLCIKNKTTCVPVQLHPSSFPKCQEAIVSPQARVKLLNKIKMDTAL
What are the official names of this protein?
Putative uncharacterized protein FER1L6-AS1, FER1L6 antisense RNA 1, FER1L6 antisense gene protein 1.
Protein: PETD_NEOYE
Sequence: MSILKKPDLTDPKLRAKLAKGMGHNYYGEPAWPNDLLYVFPVVIIGTFACSIGLAILEPSSIGEKSNPFATPLEILPEWYFFPTFNLLRVIPNKLLGVLSMAAVPAGLLTVPFIENVNKFQNPFRRPIATTVFLIGTVVSIWLGIGATMPINNAITLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PNKP_MOUSE
Sequence: MSQLGSRGRLWLQSPTGGPPPIFLPSDGQALVLGRGPLTQVTDRKCSRNQVELIADPESRTVAVKQLGVNPSTVGVHELKPGLSGSLSLGDVLYLVNGLYPLTLRWEELSTSGSQPDAPPDTPGDPEEGEDTEPQKKRVRKSSLGWESLKKLLVFTASGVKPQGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKLGVPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGRLANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFLEILEIPFRLQEHLDPALQRLYRQFSEG
What is the function of this protein?
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways.  Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
What are the official names of this protein?
Bifunctional polynucleotide phosphatase/kinase, DNA 5'-kinase/3'-phosphatase, Polynucleotide kinase-3'-phosphatase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the DNA 3' phosphatase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFG_ANAPZ
Sequence: MSSKGDLSKCRNIGIMAHIDAGKTTTTERILFYTGKQNRIGEVHEGAASMDWMEQEKERGITITSAATTCFWNGCRINIIDTPGHVDFTVEVERSLRVLDGAVAVFDGVAGVEPQSETVWRQADRYDVPRICFVNKMDRVGADFYTCVDMIVDRLGAVPLVLQLPIGVDKGFVGVVDLVEMRSIIWEEDSLGAKFHYGDIPEGMLEEANKYRSKLVETAVEVDDEAMSMYLDGQDISVSLLKKCIRAGVIGSNFVPVLCGSAFKNKGVQPLLDAVVDYLPSPNDIPTIEGVSAKDPDQVMQITTSEDGKFVALAFKVMVDRFVGSLTFVRVYSGKLTGKSVVLNSSKGHTESVGRILLMHANNREDISEVKAGDIAALAGLKKTTTGDTLCDQNFPVILEKMDFPESVMELAIEPVSTADQEKMGMALSRLVAEDPSLKVFVNNESGQTILKGMGELHLEIIVDRMRREFGVEASVGAPQVAYRETITKAAEVEYIHKKQTGGAGQFAKVNILFEPLPPGSGFEFENKITCGAIPKEYIPGIQNGLELIKETGIIAGFPLIDFKATLFDGAFHEVDSSPLAFELAAKGAFREMASKAAPVLLEPIMRVEIITPDEYMGDVIGDINSRRGKVSEMQDRHNAKLITAFIPLSSMFGYVKDLRSMSQGRAQYSMFFARYERVPENVVVNDVKR
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPR45_ARATH
Sequence: MASSAQSPHFYLNPGKSNSFQSKAYKQRNVNFYWNFGIRRLFLRKSQGLSVLSSSSSSTHFSNSQLHGLCANGKLEEAMKLLNSMQELRVAVDEDVFVALVRLCEWKRAQEEGSKVYSIALSSMSSLGVELGNAFLAMFVRFGNLVDAWYVFGKMSERNLFSWNVLVGGYAKQGYFDEAMCLYHRMLWVGGVKPDVYTFPCVLRTCGGIPDLARGKEVHVHVVRYGYELDIDVVNALITMYVKCGDVKSARLLFDRMPRRDIISWNAMISGYFENGMCHEGLELFFAMRGLSVDPDLMTLTSVISACELLGDRRLGRDIHAYVITTGFAVDISVCNSLTQMYLNAGSWREAEKLFSRMERKDIVSWTTMISGYEYNFLPDKAIDTYRMMDQDSVKPDEITVAAVLSACATLGDLDTGVELHKLAIKARLISYVIVANNLINMYSKCKCIDKALDIFHNIPRKNVISWTSIIAGLRLNNRCFEALIFLRQMKMTLQPNAITLTAALAACARIGALMCGKEIHAHVLRTGVGLDDFLPNALLDMYVRCGRMNTAWSQFNSQKKDVTSWNILLTGYSERGQGSMVVELFDRMVKSRVRPDEITFISLLCGCSKSQMVRQGLMYFSKMEDYGVTPNLKHYACVVDLLGRAGELQEAHKFIQKMPVTPDPAVWGALLNACRIHHKIDLGELSAQHIFELDKKSVGYYILLCNLYADCGKWREVAKVRRMMKENGLTVDAGCSWVEVKGKVHAFLSDDKYHPQTKEINTVLEGFYEKMSEVGLTKISESSSMDETEISRDEIFCGHSERKAIAFGLINTVPGMPIWVTKNLSMCENCHDTVKFISKTVRREISVRDAEHFHHFKDGECSCGD
What is the function of this protein?
Regulates the RNA editing of the chloroplast transcript accD, and is essential for the early stages of chloroplast biogenesis (PubMed:20143129, PubMed:19500301, PubMed:21294841).  Required for the RNA editing of the chloroplast transcript ndhF (PubMed:20143129, PubMed:21294841).
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g15510, chloroplastic, Protein EARLY CHLOROPLAST BIOGENESIS 2, AtECB2, Protein VANILLA CREAM 1.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MSRA2_ARATH
Sequence: MDSSLKTQEPQVVETSPSPVAQEPPQVADKPAIVPSPIAQEPDNDVPAPGNEFAEFAAGCFWGVELAFQRIPGVTVTEVGYTHGISHNPSYEDVCTNTTNHAEVVRVQYDPKECTYETLLDLFWSRHNPTTLNRQGELLGAQYRSGIYFYTPEQEKLARESLEKEQKKLEDKIVTEILPAKKFYKAEEYHQQYLVKGGMHGNAQSPAKSCKDPIRCYG
What is the function of this protein?
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins.  Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation.  Prevents cellular oxidative damage in long nights.  MSRA family specifically reduces the MetSO S-enantiomer.
What are the official names of this protein?
Peptide methionine sulfoxide reductase A2, AtMSRA2, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase, Protein-methionine-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RL5_STRGG
Sequence: MTATTAPRLKTRYREEIAGKLREEFSYENVMQVPGLVKIVVNMGVGDAARDSKLIDGAVKDLTTITGQKPAVTKARKSIAQFKLREGQPIGCHVTLRGDRMWEFLDRTLSLALPRIRDFRGLSPKQFDGRGNYTFGLTEQVMFHEIDQDKIDRVRGMDITVVTTATNDDEGRALLRHLGFPFKEN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: NDBG1_LYCMC
Sequence: MKSMIAVLLLALVATSMAGYLGLGYGGLYGAYGGLYGAGVPVGRAVAYSSSIRHPGFGGLGVLGGYGGYGYGLGLGAYGYGGYGLGYGLGLGLGHGKIW
What are the official names of this protein?
Glycine-rich protein.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LYZL6_BOVIN
Sequence: MTSPLLISLASCLVAVNQASLIGRCDLAKVLHQEDLDGFEGYSLTDWLCLAFVESDFNITKVNENTDGSFDYGIFQINSHYWCNDYQSRTENNCQVDCQELLSPNLLAIINCAKKIVSGAGGMKNWVKWRLHCAGRPLSYWMTGCHLA
What is the function of this protein?
May be involved sperm-egg plasma membrane adhesion and fusion during fertilization.  Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus.  Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH.  Bacteriolytic activity is pH-dependent, with a maximum at around pH 5. 6 (By similarity).
What are the official names of this protein?
Lysozyme-like protein 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted. Cell surface. Cell projection, cilium, flagellum. Note=Detected in the post- acrosomal area and midpiece of mature spermatozoa.
Protein: SERC_LISIN
Sequence: MERVYNFSAGPAVLPVPVLEKVQRELLSYNGSGMSVMELSHRSELFQNIIDDAESLIRELMGIPENYKVLFLQGGASLQFDMVPMNLANGKKAVYVNTGSWAKKAISEAKKIQGVEVEVIASSEDRNFSYIPEIPTVSTDAAYLHVTTNNTIEGTAMFDVPDSAVPVVADMSSNILSSVYDVKKFGLIYAGAQKNIGPAGLTLVIVREDLIGQVEGLPSMLDFKVQAENGSMYNTPPTFAVYVAKLVFEWIKEQGGVAGIEALNRKKAALLYDYIEQSDFFSSPVEPSARSLTNIPFVTNSAEFDKAFVKEAEANGFKNLKGHRSVGGMRASLYNAFPIEGVEALIAFMEKFANARKGGEVRV
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTRC_BACSU
Sequence: MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKIASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQNDYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAGNTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVLHTK
What is the function of this protein?
Catalytic subunit of the KtrCD potassium uptake transporter.  The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.
What are the official names of this protein?
Ktr system potassium uptake protein C, K(+)-uptake protein KtrC, ORF4.
What is the protein family that this protein belongs to?
Belongs to the KtrA potassium transport family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CLIC6_RAT
Sequence: MAEATEPKEVSSGSQGQPEGAVIEGPGEPGAADLEGREASEGAAEAPRDLGEGAEAMASGKEEGGCGQDGEIGEVQAQDPRPGPGTETPGTSGAPGEAEAAECDSEGALIPQSGGGAKRQQVQGTSSGLDAQGEAPEVPEDARREPEDPKASEAGEEAESGQEALGGSAPESQINPEVQGPVGDNMDTEAPAGEPQGSEGEPQGGGESSPQPQDEAIEIAAAEVGGHEPGELAGASAADAKGEGETLRKDGFEEAAPEEARVDSGENGFEEAAPEEARVDSGENRDQGRLQEETGEEEARPESGLKGPCEEAIQEKAPDGSLDGEEAKSTGHEESQVELSNHLAEETSAQGGEELGRVNGRRENGPASEEGDLGQEHDITLFVKAGSDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLVPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANDIYEKNLLRALKKLDSYLNSPLPDEIDAYSTEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKYRGFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDAAKRMK
What is the function of this protein?
May insert into membranes and form chloride ion channels.  May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
What are the official names of this protein?
Chloride intracellular channel protein 6.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). Colocalizes with DRD3 at the plasma membrane.
Protein: HPRK_LACGA
Sequence: MVEAVKVSELVKDVPSLKIIEGKEYLSQKLIDTSDISRPGLELTGYFDFYPKNRIQLLGRTEISYSARLDHDLRERVFNKMATPETPCFIVSRGLPIPSEMLEAAEKEKIPVFSSNMATTHLSSVITQFLDEKLAPRKSIHGVLVEIYGMGVLIIGNSGVGKSETALDLVKRGHRLIADDRVDVYQKDDKTVVGEAPKILKHLMEIRGIGIIDVMNLFGAGAVKDSTEIQLIICLQNWDPKANYDRLGFNEKTREIFEVDVPQVTVPVKVGRNLAIIIEVAAMNFRAKKMGYDASQKFEQNLTELISDNSKKDEGESKK
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: IL24_HUMAN
Sequence: MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL
What is the function of this protein?
Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232).  Possesses antiviral functions and induces the type I intereferon response during influenza infection (PubMed:27687232).  Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632).  In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428).  Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity).  In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
What are the official names of this protein?
Interleukin-24, IL-24, Melanoma differentiation-associated gene 7 protein, MDA-7, Suppression of tumorigenicity 16 protein.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TREA_ECOLU
Sequence: MKSPAPSRPQKMALIPACIFLCFAALSVQAEETSVTPQPPDILLGPLFNDVQNAKLFPDQKTFADAVPNSDPLMILADYRMQQNQSGFDLRHFVNVNFTLPKEGEKYVPPEGQSLREHIDGLWPVLTRSTENTEKWDSLLPLPEPYVVPGGRFREVYYWDSYFTMLGLAESGHWDKVADMVANFAHEIDTYGHIPNGNRSYYLSRSQPPFFALMVELLAQHEGDAALKQYLPQMQKEYAYWMDGVENLQAGQQEKRVVKLQDGTLLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLNTLRTTSIVPVDLNSLMFKMEKILARASKAAGDNAMANQYETLANARQKGIEKYLWNDQQGWYADYDLKSHKVRNQLTAAALFPLYVNAAAKDRASKMATATKTHLLQPGGLNTTSVKSGQQWDAPNGWAPLQWVATEGLQNYGQNEVAMDISWHFLTNVQHTYDREKKLVEKYDVSTTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPKEQPCDNVPATRPLSESTTQPVKQKEAEPTP
What is the function of this protein?
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
What are the official names of this protein?
Periplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NO40_LOTJA
Sequence: MRFCWQKSIHGS
What is the function of this protein?
Modulates the action of auxin, and may function as plant growth regulator that alters phytohormone responses.
What are the official names of this protein?
Early nodulin-40.
Protein: MPPB_RAT
Sequence: MAAAAVSRTLLPVAGRRLWGFTRRLPLRAAAAQPLYFGGDRLRSTQAAPQVVLNVPETQVTCLENGLRVASENSGISTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSISRKDLVDYITTHYKGPRIVLAAAGGVCHNELLELAKFHFGDSLCAHKGDVPALPPCKFTGSEIRVRDDKMPLAHLAVAIEAVGWTHPDTICLMVANTLIGNWDRSFGGGMNLSSKLAQLTCHGNLCHSFQSFNTSYTDTGLWGLYMVCEQATVADMLHAVQKEWMRLCTAVSESEVARAKNLLKTNMLLQLDGSTPICEDIGRQMLCYNRRIPIPELEARIDAVDAEMVREVCTKYIYGKSPAIAALGPIERLPDFNQICSNMRWTRD
What is the function of this protein?
Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (PubMed:12433926) (Probable).  Preferentially, cleaves after an arginine at position P2 (PubMed:12433926).  Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (PubMed:22354088).
What are the official names of this protein?
Mitochondrial-processing peptidase subunit beta, Beta-MPP, P-52.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PAN1_SCHPO
Sequence: MSYPNQMNGSMYGYGANNGVQPGFDSYGMPINQGGMNYQQQTYPYQQPYQPDGYAGNTMLPFQQSQPATQFNNGFGYASQPTGSVADYGQQQQQMYGYNGMMPQTMNNTGFMQPQQTGAIPGFAPQPTGFVQPQPTGFMSQQPASFMQPQRTGGAGFIQPQRTGAMPAYQPQMNNFMQPQKTGGFAPQATGFMQTQPFGAAPSFAPQPTGFVQPQQTGVVMPPQPTGYLQAQPTGPFASFVQPQQTASFMPAAQPLKPQKTGQIHNSKAMDTRLSFVSAADQAKFEQLFKSAVGREEAMSSEIGKAILVRSKLPTVQLSKIWRLSDTTRSGRLLFPQFVLAMYLCNLGLTGKPIPDKVPDGILNEVNAMVDAISFSLDENYAKPTQPIPQAAAQQMAAQMFGGFQQAAGIPSQITGFQPQAMMPQRTGMQPQMTGFQQPMIPQRTGMQPQMTGFQQPMMPQRTGLQPQMTGFQQPMVPQRTGMQPQMTGFQQPMMPQRTGLQPQMTGFQQPMVPQRTGMQPMMPGLQQPMAPQRTGMQPMMPQRTGMQPQMTGFQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMAPQRTGMQPQMTGGPMLPQRTGGMAPQPTGMPGQWGFINTPLSNLPGIEALGQQMMPNAPSGGLNNTFQQKKDIPWAISKEEKRIYDQIFDAWDKERKGTLGGNAVLEIFGQSKLTRTELEHIWNLCDHGDKGSLDRDEFAVALHLIYRKLNGNEVPAVLPPELIPPSTRNFTESLNQVKNLIKNDTSNRKPFGAENQSKLKKNSFYDNPSETTEKDATLYRHNDSDASAYVSSARRRDFKEEKIESAPPIINDIDSEIASLKKRIHEKSLVVNALEDKKLAATPANDVQNDSLIYRIKSVQDEINRLSTSNKSPEVASMNVRLEELSTRVSKMLSDINEVDHTIASLSLKLFQAEDTKNSYDQTSPEATQERNRTISSKLAEMEKQKNESKAALEQMKNYVTNIENNIRAKLLPSAANDDAWLSQNVVDESVTRVVKELPVPAPAAPQTLNPPSVSTVQQSKPIESNTHTPEVKATSESPSASSNLEDRAARIKAEAQRRMNERLAALGIKPRQKGTPSPAPVNSATSTPVAAPTAQQIQPGKQASAVSSNVPAVSASISTPPAVVPTVQHPQPTKQIPTAAVKDPSTTSTSFNTAPIPQQAPLENQFSKMSLEPPVRPAVPTSPKPQIPDSSNVHAPPPPVQPMNAMPSHNAVNARPSAPERRDSFGSVSSGSNVSSIEDETSTMPLKASQPTNPGAPSNHAPQVVPPAPMHAVAPVQPKAPGMVTNAPAPSSAPAPPAPVSQLPPAVPNVPVPSMIPSVAQQPPSSVAPATAPSSTLPPSQSSFAHVPSPAPPAPQHPSAAALSSAPADNSMPHRSSPYAPQEPVQKPQAINNIAPATNLGTSQSFSPRMGPVNNSGSPLAMNAAGQPSLAVPAVPSAPSNHFNPFAKMQPPAPSPLQPSGHDSDNWSQHGDEEEEDSEDDIRSSKDAAALAAKLFGGMAPAHPVSTPPVRPQSAAPPQMSAPTPPPPPMSVPPPPSAPPMPAGPPSAPPPPLPASSAPSVPNPGDRSALLQQIHTGTRLKKTVTTDKSKPIAGRVLDASDGNSSAWYGNLS
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein pan1.
What is the protein family that this protein belongs to?
Belongs to the PAN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.