PharMolix/UniProtQA huggingface dataset:
Protein: SOX1_XENTR
Sequence: MYSMMMETDLHSPGVQPPSNTGQTGGGGGNKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLHAAGGGHMGVGLSPGGGGGGTGGVVVQRLESPGSGASAGGYAHMNGWANGAYPGSVAAAAAAAMMQEAQLAYSQQQQQHPGSGGHHPHHHPHHPHHHPHHHPHHNPTPHPPPPPPQPMHRYDMSALQYSPLPGAQTYMTASPSGYGALGYSSSQQQHQGSPSSAAVAAAAAAAAAAAASSGALGALGSLVKSEPSVSPPVSGGGPHNRPPCPGDLREMISMYLPSGGEAGDPAAAAAAAAAAAAAATSRLHSLPQHYQGAGTGVTGTVPLTHI
What is the function of this protein?
Transcriptional activator.  Participates in neural induction (By similarity).
What are the official names of this protein?
Transcription factor Sox-1, SRY (Sex determining region Y)-box 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: KCNS1_LEMCA
Sequence: MLMLLVRGTHFENNWSKLIPPAPLDATVSEPPVPDSGEPDSGVPWRRSDEALRVNVGGVRRRLSARALARFPGTRLGRLQAAKSEEQARRLCDDYDAAAREFYFDRHPGFFLSLLHFYRTGRLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRVARPRAWDEDSDTPSSVDPNPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVATVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLASVALGGNNHGGTSGEELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFDTIPACWWWGTVSMTTVGYGDVVPVTLAGKLAASGCILGGILVVALPITIIFNKFSHFYQRQKALEAAVRNSGHREFEDLLSSVDGVSDASLETSRETSQEGRSADLEAPSESPKPQIY
What is the function of this protein?
Potassium channel subunit that does not form functional channels by itself.  Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
What are the official names of this protein?
Potassium voltage-gated channel subfamily S member 1, Delayed-rectifier K(+) channel alpha subunit 1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2.
Protein: LKB2B_MANHA
Sequence: MEANHQRNDLGLVALTMLAQYHNISLNPEEIKHKFDLDGKGLSLTSWLLAAKSLALKAKHIKKEISRLHLVNLPALVWQDNGKHFLLVKVDTDNNRYLTYNLEQDAPQILSQDEFEACYQGQLILVTSRASVVGQLAKFDFTWFIPAVIKYRKIFLETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNIITVALAIVIIFEIVLSGLRTYVFSHSTSRIDVELGAKLFRHLLSLPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSFIFFAVMWYYSPKLTLVILGSLPCYILWSIFISPILRRRLDDKFARSADNQAFLVESVTAINMIKAMAVAPQMTDTWDKQLASYVSSSFRVTVLATIGQQGVQLIQKTVMVINLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTEQYQGKLSLPEIKGYISFKNIRFRYKPDAPTILNNVNLEIRQGEVIGIVGRSGSGKSTLTKLLQRFYIPENGQVLIDGHDLALADPNWLRRQIGVVLQDNVLLNRSIRENIALSDPGMPMERVIYAAKLAGAHDFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMQNMQKICQGRTVILIAHRLSTVKNADRIIVMEKGEIVEQGKHHELLQNSNGLYSYLHQLQLN
What is the function of this protein?
Part of the ABC transporter complex LktBD involved in leukotoxin export.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).
What are the official names of this protein?
Leukotoxin translocation ATP-binding protein LktB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RT51_ASHGO
Sequence: MSSSNLSSILRNSRIAQVPKPKGPLFSPDKKYVPTHQLIENKASTMHRQEWGMKSSIPSRSKSRYLIFDELDTQQRLTSFEAIGQYQWNRIRIQELGVVPERATAGNSFQTSADANAPSNPLFSGFSSRLSARTPLSSFFGLTSKSDAKQWKAAEKKVAALRPAFKKWLQDHHPHLIIHKDQMDPADFRKRAVEFITEIATRSSGAGGSWKVVGNGGLTYGLKGRLQQSPLGIKQNTVVEGRILQTNGMEKSVAAAGFVGNGMLGTNLRKVDYAMGDLVRTARFPFEVKQARLLENGRLLMDMSLIEPKNTARKYGYGAKENKNRTYIFQRGAVNERKISSEESAQQAEELLNILTNFEN
What is the function of this protein?
Involved in mitochondrial genome encoded proteins translation.
What are the official names of this protein?
37S ribosomal protein MRP51, mitochondrial, Mitochondrial ribosomal protein 51.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NEF_HV1M2
Sequence: MGGKWSKSSIVGWPAIRERIRAAEGVGAVSQDLDKRGAITNSNTGATNADLAWLEAQEEEVGFPVRPQVPLRPMTYKAALDLSHFLKEKGGLEGLIYSRKRQEILDLWVYHTQGYFPDWQNYTPGPGPRFPLTFGWCFKLVPVDPEEVEKANEGENNCLLHPMSLHGMEDDDKEVLKWQFDSRLALRHIARERHPEYYKD
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: XPOT_PODAN
Sequence: MDAQIENAIEVAWNPSSSQELKGQAFEYLNQLRVDPQAWQVCIGLFTRSPPASEVVRLVSLEIINNAVHSEALDAASLVYLKQSLLEYIGRTYTSNTQSQVDPAHLQNKLTQTLTYLFVFLYREHWSSFVQDFYAIAQNDNLPGVILYLRILSSIHDEIADLMLSRQEQEAKRNSDLKDLIRERDMAKIATSWTDILSRYSNQHDGVVEMTLKIIGKWVSWIDISLVINQQMLGLLLPLVGRSNASGGEDKVRDIAVDTFTEIVSKKMKASDKIEMINFLQLREIITELLASPPLNEWKGTSQYDTDLAEVVAKLVNAIMSDIVRVLEDGKVDNDTRAKAEQLLQYFLPSLLRLFSDEYDEVCSTVIPSLTDLLTFLRKVRTLPATYAEMLPPILNAIVLKMRYDETSNWGLEDEQTDEAEFLELRKRLQILQKSVAAVDENLCMEFMSNLVGNMFSTLQQQGSQMDWRDLDLALHEMYLFGELALPNMGLAAKSQPNPVAAERLALMMSKMVDSGIANYAHPAILLQYMEICVRYHSFFESHQNYIPRVLENFVRLVHHEHVRVRTRSWYLFLRFVKTLRAQVGNVAKTVIESISDLLPIKAEVPSNDADDDMSSDESDHSADAVFNGQLYLFEAVGCVSATSATPVADQALYARSVMEPLFSDMSVHLERAKAGDAQAILQIHHIIMALGTLANGFADTPLGHTKARAQPAQEISAEFTRASEAILIALNQLNTSDEIRAACRSAFSRLLGVLGSAVLPQLPQWIEGLLSRSSSKDEMAMFLRLLEQIVYNFKGEISNILDLLLTPLLQRVFGGLSEPINGTDDEIQLQELRREYVSFVQVIFMNDLGGVLVSAANQGNFESLVSSIFSVAKNLNHGNLVASRIAFNVLSRMITQWGGPDIITPGENPVATGPPSPTIPGFEQFMLSQFHGVCWDVLQDGGFRPSSDATSRQILNEIAGIQQAIWMKTADLYINHVQNQLGQDSNDFLRTLTTTTARKPLVDWFLALLKGRK
What is the function of this protein?
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.  Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
What are the official names of this protein?
Exportin-T, Exportin(tRNA), Karyopherin-beta, tRNA exportin.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: LUXC_PHOLU
Sequence: MNKKISFIINGRVEIFPESDDLVQSINFGDNSVHLPVLNDSQVKNIIDYNENNELQLHNIINFLYTVGQRWKNEEYSRRRTYIRDLKRYMGYSEEMAKLEANWISMILCSKGGLYDLVKNELGSRHIMDEWLPQDESYIRAFPKGKSVHLLTGNVPLSGVLSILRAILTKNQCIIKTSSTDPFTANALALSFIDVDPHHPVTRSLSVVYWQHQGDISLAKEIMQHADVVVAWGGEDAINWAVKHAPPDIDVMKFGPKKSFCIIDNPVDLVSAATGAAHDVCFYDQQACFSTQNIYYMGSHYEEFKLALIEKLNLYAHILPNTKKDFDEKAAYSLVQKECLFAGLKVEVDVHQRWMVIESNAGVELNQPLGRCVYLHHVDNIEQILPYVRKNKTQTISVFPWEAALKYRDLLALKGAERIVEAGMNNIFRVGGAHDGMRPLQRLVTYISHERPSHYTAKDVAVEIEQTRFLEEDKFLVFVP
What is the function of this protein?
LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
What are the official names of this protein?
Long-chain acyl-protein thioester reductase, Acyl-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the LuxC family.
Protein: PMSD_PSEE4
Sequence: MRELTSMQAACWIGRTAHAALGKVSAHLYAEFDGHAIDLERLRAALQQVSLLHPMLRLRIDQDGLQGIAPMEQAPRLEVDDLRGLAEPEVAQRLLRKREAWTHQQLDLRHGCAARFSVSQLEGERSRLHVDTDMIAIDPSSLRVLMEDLARCYEAPDAPVATPPSFFAWWDAVRADPALKATQERDRQWWRARLDSIAPAPTLPLLDVQPAQAHSQRLTTWLDANQHIALRQLARERKVTLSTLMLGLFASALGAQTGDRQFRLNVPSFWRAPLIDGVERIVGEFANVLIVDVDLDAAPDIAALCNQLAKTTAACMAHSAYPGVNLMRDLSRHHGTPQLAPVVFTAALDMPGKELFSPRVKNAFGPLGWLISQGPQVALDAQIACADGGILINWDIRLDALPEAWVTQLFERFVDLASEVARQPATLDQALPRAPEKRPLNPLQQAYLLGRTTQMPLGGVAMQEFREYRGMMDSAVLRSRLDAMVRRHPSLRTRIDADRRVQYVSDEVRLNLDEVDLGHLPLAEALGVIDARREDYAHALSPLDRSPWNVTVFHLAHGERVVFVRLDALILDGRSIATLLVELFEGQLEETPQVDTGAPKADQTEQRTADAAYWNTKLAAVDGAPRLPWSVPLDQAGVARYERQSLVVPRETFKKFCMVGARQRLFKNTTLMAVILEVLSHWVSEGGLCVAVPVAPPSDAAFANRSSFLAINWNRAAGSFAERSAGLQVDVLEGLQHLAYSGVDLARQLFERHGPGPVLPVVITNGFSWPVAPSDSAMRLQGGLTQTPQVAMDIRFWADADGALQLDIDYAREVLAPALVSDFLGTLGRAIGQIAGAGEFALAPAALIDTDHYRLNSPVEAACRDGYLARIADHLFTPGNHKTALISGERRLSYSELGDGVARIIAALRARGIGQGQVVAICLPRSPEHTMLTLACALTGVIWVPIDVAAPAERRHYLLENCHPDLVVLGQAQTLEQPSTTCAALLATPAAAPGHLADLSLNEAPGYYLYTSGTTGKPKCVVLNNRATANVIGSTLAEWRVTERDVFLSVTPLHHDMSVFDVFGSLAAGATLVLPAPGEDKDALRWNQLVAEHQVTLWCSVPAILEMLLACRGEHGLQSLRLIAQGGDYIKPAVIAGLRELLPQARLISLGGPTETTIWSIWHEIGADDRKLIPYGRPLPGNRYFVLDAQGRHCPVGVVGRIHTAGANLALGYLLDGALQQSDFITVDDEHGQAVRAFRTGDCGRYRVDGTLLFDSRVNGYVKVRGVRVSLPDIEMVLNQHPALRHVLVVDYGEPRLGEVCLGALYVCDPQAAEPSMAELRDYAREHLPHSHVPTRLLGVAALPLSQNGKPDRRRARELLSAPATASVRDKVLAIYLQVLGHSNEAGTDSAVDFISLGLRPPHLKAVAAQLQAQFGVSLSPGQLLRCRNAQEVERLLG
What is the function of this protein?
Involved in the biosynthesis of the siderophore pseudomonine.  Specifically adenylates L-threonine and loads it onto a peptidyl carrier protein, via a thioester linkage to the phosphopanthetheine moiety (PubMed:18710233).  May function in trans to generate substrate-bound PmsG (PubMed:18710233).  Activates proteinogenic L-Thr preferentially over L-allo-Thr or D-Thr (PubMed:18710233).
What are the official names of this protein?
Pseudomonine synthase PmsD, L-threonine--[L-threonyl-carrier protein] ligase, Nonribosomal peptide synthase PmsD.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PROA_XYLFT
Sequence: MSHIRHLAQQCRDAARILATLSTDAKRRLLETMATALNTDAATILAANAADLDAARTQQVGTAMLDRLALDPQRLAAMADALRDIAALPDPVGQVTRDDRRPNGIHIQKIRVPLGVIAMIYEARPNVTADAAALCIKAGNGIILRGGSEAIRSNIAIATALQRALRLASLPETALILVQDMARHTMLELLQLSDLIDLVIPRGGEGLIRFVAEHARIPVIKHYKGVCHQFVDASADIEMAIRLLIDGKTTRPAACNALETLLVHTDIAPRFLPAAAAALRPYGVQLRGDHATCTLLPDVLLATDADYAAEYLDLILAIRIVPNLDAALEHIRRYGSDHTEVIVTADPAHADTFVQQLPSAVVMVNASSRFSDGGALGLGAEIGISTTRLHAYGPMGLDALTVERFVVRGQGQVRHCPPYPPAPRR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCSB2_KOMSB
Sequence: MKMVSLIALLVFATGAQAAPVASKAPAPQPAGSDLPPLPAAPPQAAPPAAASAAPPATTPAADASAASAADAVVDNAENAIAGSDVATVHTYSLRELGAQSALKMQGAATLQGLQFGIPADQLVTSARLVVSGAMSPSLQPDTSAVTITLNEQFIGTLRPDPTHPTFGPLSFDINPIFFISGNRLNFSFASSSKGCTDPSNGLFWASVSEHSELQITTIPLPPHRQLSRLPQPFFDKNVKQKIVIPFVLAQTFDPEVLKATGILASWFGQQTDYRGVTFPVFSTIPQTGNAVVVGVADELPSALGRQAVSGPTLMEVANPSDPNGTILLVTGRDRDEVITASKGIGFGSSTLPTANRMDVAPIEVGARVANDAPSFIPTNRPVRLGELVPDSALQAEGYAPGALAVPFRVSPDLYTWRDRPNKLNVRFRAPPGPIVDVSRSSLNVGINDTYLEAYPLREPDSPLDQLLHGVGLGHRNNDSVQQHTMPIPTYRVFGQNQLLFYFEMAAMVEPGCKPGPSTFHMGIDPNSTIDLSNSYHITQMPNLAFMASAGFPFTTYADLSRSAVVLPEHPNGMIVSAYLDLMGFMGATTWYPVSGVDVVSSDHVNDVADRNLIVLSTLANSGDVSQLLSNSAYQISDGRLHMALRSTLSGVWNLFQDPMSAINSTAPTDVESTLTGGVAAMVEAESPLASGRTVLALLSGDGQGLNNLVQILAQRKNQAKIQGDLVLAHGDDLTSYRSSPLYTVGTVPLWLKPDWYMHNHPSRVVVVGLFGCLLVVAVLMRALTKHALRRRRELQEERQRT
What is the function of this protein?
Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
What are the official names of this protein?
Cyclic di-GMP-binding protein, CDGBP, Cellulose synthase regulatory subunit, Cellulose synthase protein B.
What is the protein family that this protein belongs to?
Belongs to the AcsB/BcsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein.
Protein: LEUC_ASHGO
Sequence: MMTNGAKTLYDKVFEAHIVHQDESGSCLLYIDRHLVHEVTSPQAFEGLKTAGRPVRRTDCTLATVDHNIPTESRRHFRNTESFIKEADSRLQVQTLEQNVKDFHVPYLGMSDERQGIVHIIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTVIQSKSKNMRIHVEGSLSPGITSKDLILHIIGVIGTAGGTGCVIEFTGQAIQELTMEARMSMCNMAIEAGARAGMIQPDETTFEYLKGRPLAPTGAEWEKAVTYWKTLKTDEDAVFDISVTVKGADIRPTITWGTSPQDALPIDAAVPDPANVSDPIKRSGMEAALEYMGLEPNTLLKDIKIDKVFIGSCTNARIEDLRAAAAVVDGHRIAPTVKRAMVVPGSGLVKKQAEAEGLDKIFEAAGFEWREAGCSMCLGMNPDILGPKERCASTSNRNFEGRQGRLSRTHLMSPAMAAAAGIMGHFVDIREFEFKESSAPKVEVRHDTDSSTLEEANYGHAKEEPPSAELSDVAKQEKVNDIPVSNSSTQSPGSAPSADAGLQPFLQLQGIAAPLDKANVDTDAIIPKQFLKTIKRTGLKEGLFYDWRFAKHADGKVTGTDFVLNREPYRKATTLVVTGPNFGCGSSREHAPWALKDFGIMCIIAPSFGDIFYNNSFKNGLLPIRLPQDVIKEKLYPIASAGGELVIDLPAQQIADGEGHILVTQFDVEPSRKHCLVNGLDDIGLTLQKERFIADYEAMRRRDFSFLEGGSKLLPRISHSKPTSMPQAANDW
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: EX7S_ECO27
Sequence: MPKKNEAPASFEKALSELEQIVTRLESGDLPLEEALNEFERGVQLARQGQAKLQQAEQRVQILLSDNEDASLTPFTPDNE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_HAEIE
Sequence: MSLNIETTQGLERRVAITVPTEIVSKAVREEFKRAAKNVRVDGFRKGHVPAHIIEQRFGASIRQDVLNDLLPRHFFDAVIAEKINIAGRPTFAIETFEEGKDLVFTATFEVYPEVKLQGLENIKVEKPTVEITEADIDKMIDVLRKQQATWAESQDVVKADDRVTIDFVGSVDGEEFEGGKATDFVLFMGQGRMIPGFEEGIIGHKAGEQFDIDVTFPAEYHAENLKGKAAKFAITLKKIENMVLPELTDEFVAKFGPNTKSVADLRAEIRKNMERELKNALVSRVKQQVINGLIEQNPIDVPASAVEEEINVLRNQAAQRFGGNAQQTAQLPRELFEAEATRRVQVGLLFSEVIKSNELKADEERAKAMIADIASAYEQPAEVVEYYSKNEELMNNIRNVVLEEQAVDAVLAKAQVTEKVSSFDEIMNPQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ISPG_PSEAB
Sequence: MSIHSASPIIRRKSRKIWVGNVPVGGDAPIAVQSMTNTETCDVAATVAQIRRLEDAGADIVRVSVPDMDAAEAFGKIKQQVNVPLVADIHFDYRIALRVAELGVDCLRINPGNIGREDRVKAVVDAARERNIPIRIGVNAGSLEKDLQKKYGEPTPEALLESAMRHVDHLDKLDFQNFKVSVKASDVFMAVAAYRLLARQIEQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAADPVEEIKVGFDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPMDVAVIGCVVNGPGEAKEAHVGLTGGTPNLVYIDGKPSQKLTNDNLVDELERLIRQKAAEKAEADASLIARG
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: NACHO_MACFA
Sequence: MASPRTVTIVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKPLPGNAEEQPSLYEKAPQGKVKVS
What is the function of this protein?
Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (By similarity).  Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (By similarity).  Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity).  Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (By similarity).  Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity).
What are the official names of this protein?
Novel acetylcholine receptor chaperone, Transmembrane protein 35A.
What is the protein family that this protein belongs to?
Belongs to the DoxX family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum membrane; Multi- pass membrane protein. Note=Shedding may lead to a soluble peptide.
Protein: YOP1_SCHPO
Sequence: MSFQVRVKQNMQDLDNRLAAFPQLNSLEKNFGVSKLYVFLTAAGIYALFLFLNWGGFLLTNLLAFAMPAFFSINAIETTNKADDTQWLTYYLVTSFLNVIEYWSQLILYYVPVYWLLKAIFLIWLALPKFNGATIIYRHLIRPYITPHVIRICKSVSRQNAAPAPTASSFAHTTATDIPPSI
What is the function of this protein?
Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole.  Induces high curvature in membranes and causes membrane tubule formation.  Involved in membrane/vesicle trafficking (By similarity).  Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator (PubMed:20434336).
What are the official names of this protein?
Protein yop1.
What is the protein family that this protein belongs to?
Belongs to the DP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Enriched at the cell equator during mitosis.
Protein: ILVD_NOVAD
Sequence: MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRINIPVVFVSGGPMEAGKVILKGKEHALDLVDAMVAAADESFTDEEVTAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRQRLFLEAGRLVVDLCKRYYEQDDESVLPRSIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVNFTMSDIDHLSRKVPCLSKVAPAKSDVHMEDVHRAGGIYAILGELDRAGLLHTHLPTVHSRTLGDALNQWDVKRTNSPTVQEFFRAAPGGVPTQVAFSQDRRWKELDLDRETGVIRSAEHAFSKDGGLAVLFGNIAREGCIVKTAGVDDSILKFTGPAKVYESQDAAVTAILTGQVTSGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGAACALLTDGRFSGGTSGLSIGHVSPEAAEGGEIGLVENGDVIEIDIPNRTIHLAVADDVLAQRRAEQEAKGWKPVKERPRKVSTALRAYAAMTTSAARGAVRDLSQLKID
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: AROE_BLOFL
Sequence: MSSFAIFGNPVSHSKSPKIYSMFANEFGMCGEYDLKVASDDNFYNLLYQFFDMGGFGANITVPFKKRAFLLCDNLTDRSILSSTVNTIKKQLDGTLLGDNTDGIGLINDLKRLNWISIDNAFIDMTCNNIQETANILLIGSGGAAQSIIPVLLDIKKCCVNIINRTFFNAQRLVQYYHSIGRQNISCIDLNNLLCEKNACKKYDLIINASSSSMNNDLPCISSFLITPFTKCYDLFYGNQDTIFVKWCKKNGSNYCVDGLGMLIEQAAYAFYLWHGKKPSVPIVLNAFRSELCK
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: SAS1_BACCR
Sequence: MGKNNSGSRNEVLVRGAEQALDQMKYEIAQEFGVQLGADTTARSNGSVGGEITKRLVAMAEQQLGGRANR
What is the function of this protein?
SASP are bound to spore DNA.  They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation.  They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light (By similarity).
What are the official names of this protein?
Small, acid-soluble spore protein 1, SASP.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta-type SASP family.
Protein: AROG_ORYSJ
Sequence: MALATNSAAVSGGAAAAASSAPQPRLAATFLPMRRRTVSAVHAADPAKSNGPVQAAAKASSPSTVAAPEKKPVGLGKWTVDSWKAKKALQLPEYPSQEELDSVLKTIETFPPVVFAGEARHLEERLADAAMGRAFVLQGGDCAESFKEFNANNIRDTFRILLQMGAVLMFGGQMPVVKVVGRMAGQFAKPRSDSFEERDGVKLPSYRGDNINGDTFDEKSRVPDPQRMIRAYAQSVATLNLLRAFATGGYAAMQRVTQWNLDFMDHSEQGDRRYRELAHRVDEALGFMTAAGLTVDHPIMTTTDFWTSHECLLLPYEQSLTREDSTSGLFYDCSAHMLWVGERTRQLDGAHVEFLRGVANPLGIKVSDKMNPRDLVKLIEILNPSNKPGRITIITRMGAENMRVKLPHLIRAVRNSGQIVTWITDPMHGNTIKAPCGLKTRPFDSILAEVRAFFDVHDQEGSHPGGIHLEMTGQNVTECIGGSRTVTFDDLSDRYHTHCDPRLNASQSLELAFIIAERLRRRRMRSGVNSNLPLPPLAF
What are the official names of this protein?
Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase 2, DAHP synthase 2, Phospho-2-keto-3-deoxyheptonate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II DAHP synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AOX2_CANAX
Sequence: MLTASLYKQLPVLTTTATSTYSFIRLSSTLATPPHSTTTTSPSSPAFHQPNHPQQFANPNTSVFDVSTRIYTQEGIDNNNDTKFLTKAPYPHPVFPQDECENVTVTHRETKTLGDKISFRSIQFMRQCFDLVTGYAVPKTNNPDEFKGTRWEMTEGKWLTRCIFLESVAGVPGSVAGFLRHLHSLRMLRRDKAWIETLLDEAYNERMHLLTFIKIGKPSWFTRSIIYVGQGVFTNVFFLLYLLNPRYCHRFVGYLEEEAVRTYSHLLDELAVPGKLPAFETMKIPEVAVQYWPELTPKSSFKDLILRIRADEAKHREVNHTFANLEQKTDRNPFALKIEGLNKPQPNHGINVMRPTGWEKQDLQL
What is the function of this protein?
Catalyzes cyanide-resistant oxygen consumption.  May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures (By similarity).
What are the official names of this protein?
Alternative oxidase 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the alternative oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Note=Possibly in the inner surface of the inner mitochondrial membrane.
Protein: BIPB_BURP1
Sequence: MSSGVQGGPAAHANAYQTHPLRDAASALGTLSPQAYVDVVSAAQRNFLERMSQLASEQCDAQPAAHDARLDDKPALRAPQERDAPPLGASDTGSRASGAAKLTELLGVLMSVISASSLDELKQRSDIWNQMSKAAQDNLSRLSDAFQRATDEAKAAADAAEQAAAAAKQAGADAKAADAAVDAAQKQYDDAVKQGLPDDRLQSLKAALEQARQQAGDAHGRADALQADATKKLDAASALATQARACEQQVDDAVNQATQQYGASASLRTPQSPRLSGAAELTAVLGKLQELISSGNVKELESKQKLFTEMQAKREAELQKKSDEYQAQVKKAEEMQKTMGCIGKIVGWVITAVSFAAAAFTGGASLALAAVGLALAVGDEISRATTGVSFMDKLMQPVMDAILKPLMEMISSLITKALVACGVDQQKAELAGAILGAVVTGVALVAAAFVGASAVKAVASKVIDAMAGQLTKLMDSAIGKMLVQLIEKFSEKSGLQALGSRTATAMTRMRRAIGVEAKEDGMLLANRFEKAGTVMNVGNQVSQAAGGIVVGVERAKAMGLLADVKEAMYDIKLLGDLLKQAVDAFAEHNRVLAQLMQQMSDAGEMQTSTGKLILRNARAV
What is the function of this protein?
Plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages.  May act in concert with other effector proteins to induce fusion of host cell membranes (By similarity).
What are the official names of this protein?
Translocator protein BipB.
What is the protein family that this protein belongs to?
Belongs to the invasin protein B family.
What are the subcellular locations of this protein?
Secreted. Host membrane. Note=Secreted via the bsa type III secretion system, and probably inserted into host membranes.