PharMolix/UniProtQA huggingface dataset:
Protein: S22AO_RABIT
Sequence: MGFDVLLDQAGSLGRFQILQIAFFFVTSMITYTHILLENFTAAIPGHRCWVPLLDNHTTSGNDSDILSQDALLRVSIPLDSNLRPEKCRRFIHPQWQLLYLNGTSPSTNEPDTEPCVDGWVYDQSSFSSTIVTKWDLVCEFQSLKSVVQTLFMSGSLLGGLMFGRLSDRYGRKAIYTWCLLQTAIADTCAIFAPTFVVFCIFRFLAGLTTINIMTNAFILATEWTVPKLQYIGITLILCSYSIGQMLLGGLAFAIRDWYTLHLTVSIPLFVLSLLSRRLVESARWLVTTNQLDEGTKALRRVARINGKKSAGEILTIEFVRSAMQEELNKAQTKTSVIHLLRAPKLRMIICFLSFIRLGASVPFMGLILNLQDLGSSIFLFQVLFGAITFISRCSAHLIMKHMDRRINQSLFFFLVGLCILVNTFLSQEMQTLRVVLATLGIGTVSAANATFFVHALELTPTTFRSTTAGINNVFSRMGSVLAPLLMTLVVYSPHLPWVMYGVFPILAGLIVFCLPETRNRPLPNTIQDVENDTKESRKVKEEDTFIKVTQF
What is the function of this protein?
Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids, as well as bile acids, driven by an outward gradient of dicarboxylates such as glutarate or succinate (By similarity).  Transports androstanediol glucuronide (5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), estrone 3-sulfate, and estradiol-17-glucuronide (17beta-estradiol 17-O-(beta-D-glucuronate)), and taurocholate (PubMed:31553721).
What are the official names of this protein?
Steroid transmembrane transporter SLC22A24, Solute carrier family 22 member 24.
What is the protein family that this protein belongs to?
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Protein: THIM_VIBA3
Sequence: MLTEQIIQSLRAVREQKPLVVNITNYVVMNNTANALLAIGASPIMAHSKQELAEMMSFSGALVINIGTLDSVWTPRMCFAVEQANANNKVVVLDPVGCGASTLRTETSREIARLADKLIIRGNASEIIALAGEQAQSKGVDALDSSDAALGAAQCLVAEYGANVVISGETDYVVTKDSVVTLNNGHPMMPYVTGMGCTLTALTGAFAAVGDESGLAAAAVLGVVGEISAESSRGPGSLQMNLLDELYQLDEETLIQRLKVQ
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: MI2D_RHIME
Sequence: MTVRFGLLGAGRIGKVHAKAVSGNADARLVAVADAFPAAAEAIAGAYGCEVRTIDAIEAAADIDAVVICTPTDTHADLIERFARAGKAIFCEKPIDLDAERVRACLKVVSDTKAKLMVGFNRRFDPHFMAVRKAIDDGRIGEVEMVTITSRDPSAPPVDYIKRSGGIFRDMTIHDFDMARFLLGEEPVSVTATAAVLIDKAIGDAGDYDSVSVILQTASGKQAIISNSRRATYGYDQRIEVHGSKGAVAAENQRPVSIEIATGDGYTRPPLHDFFMTRYTEAYANEIESFIAAIEKGAEIAPSGNDGLAALALADAAVRSVAEKRQISIA
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
What are the official names of this protein?
Inositol 2-dehydrogenase, Myo-inositol 2-dehydrogenase, MI-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: IF1A_METMP
Sequence: MRGQQTPPQQPTRVRTPRENENEVLGVIEQMLGASRVRVRCMDGKLRMGRIPGKLKRKIWVREDDVVIVTPWEVQSDEKCDVIWRYTKGQVDWLNRKGYLDFMR
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
What are the official names of this protein?
Translation initiation factor 1A, aIF-1A.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: 1101B_ASFL5
Sequence: MKLLALLCILIWLSQPGLNRPLSIFYTKQNLPRTYTPPVRELEYWCTYGKHCDFCWECRNGICKNKVWDDMPLIKQNDYISQCSIARYFDRCMYFIKPKSPYIHYMDCSQPIVYKGFSH
What are the official names of this protein?
Protein MGF 110-13L-B.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 110 family.
Protein: ADPRS_MOUSE
Sequence: MAVAAAAAATAMSAAGGGGASAARSISRFRGCLAGALLGDCVGAVYEAHDTVSLASVLSHVESLEPDPGTPGSARTETLYYTDDTAMTRALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVITVFKKLLNPKCRDVYEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGVSSSEHFLEQLLGHMEELEGDAQSVLDAKELGMEERPYSSRLKKVGELLDQDVVSREEVVSELGNGIAAFESVPTAIYCFLRCMEPHPEIPSTFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGMEQVPESWQQSCEGFEETDVLAQSLHRVFQESS
What is the function of this protein?
ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (By similarity).  Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (By similarity).  Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity).  Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (By similarity).  Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:24191052, PubMed:30830864).  Also hydrolyzes free poly(ADP-ribose) in mitochondria (By similarity).  Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (By similarity).  Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (By similarity).
What are the official names of this protein?
ADP-ribosylhydrolase ARH3, ADP-ribose glycohydrolase ARH3, ADP-ribosylhydrolase 3, O-acetyl-ADP-ribose deacetylase ARH3, Poly(ADP-ribose) glycohydrolase ARH3, [Protein ADP-ribosylarginine] hydrolase-like protein 2, [Protein ADP-ribosylserine] hydrolase.
What is the protein family that this protein belongs to?
Belongs to the ADP-ribosylglycohydrolase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Mitochondrion matrix. Note=Recruited to DNA lesion regions following DNA damage; ADP-D-ribose-recognition is required for recruitment to DNA damage sites.
Protein: RIMP_PSEFS
Sequence: MHEGVQVSSKLEELQALLAPVVVALGYECWGIEFSAQGRHSMLRVYIDKEGGVLVDDCAIVSRQISGVLDVEDPISVEYTLEVSSPGMERPLFTIDQFAKFAGEQVKIKLRSPFEGRRNFQGLLRGVEEQDVVVQVEDHEFLLPIDMIDKANIIPSFD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KI26L_DROPS
Sequence: MASSISRNGGFCGALQRAPPPMPPGLARRLSSRECYGVGKVKVMLRVSDRAPDKDSPLDPEFMALDKKKRQVTLTDPRNVCPPPQAAQERGPMVAAPKMFAFDNLFTAEDKQSDVCASALSEVIPAVLEGSDGCLLAMGYPSTGQPHTVLGGDVATGAGAGAATGTGTGTGSVAACSLGAAPCAIAWLYKGIQERRQKSGARFSVRVSAVGVSATKPDALSTDLLISHAAESDDSPGIYLRDDFLGGPTELRAPTAERAALFLDSALAGRLKSSGSTSTPAGGGPAPLESALIFTLHVYQYSLSRKGGVAGGRSRLHIIDLGGCANRSGGLPLSGIGNILLAILSGQRHPPHKDHPLTPLLKDCLAPITCHVAIVAHVLHEQSYQDALSTIQIASRIHRLRRRKHRVPMPLAVGLAQGLSGGGGSSAGSGADPSSSEISADTVIYMGPNDDATDGEHPPVYLPSLSAGDNRAIMSKALKGSGLEKPPTQMKAGLSSPMMMKKAMAAAGEKVKKLPGNSPMGSLKRQAAAGACSSPLVPHEQQQQQQQIAHGSPIPIPRHMVSKGSNVPSPKGSPLRRAHAGAHPGAALEQLEAGMRKITEEQWIDGPRVSRAKVAEARHLMREVNHVKQCETWVDGPKSLSCRSLTAGNLPAAGAQTQGYGFMDSHKKTMIRQWVETQTSQVFQSPATVSASNSPTALHWKLSQLKQKSLDLPERPAFPPEQQSMDLPQQCFESQPLLGQDMSLPPDGDEDQDSGPSEVPPALPLFDDPLGSRDISHDSLHRMLSRHVSREQLHEADLVASRASSSHHQHQHHRPSSQRSIDCGLQVTEEEIARTMAREQEHSMHPLSALSHCDNLSFVSSFNMACESFSECGERARHQFDQLARLHEIFTSQLAMAEVTPSAALFRTDVSSVFSEPVFRFNVGQSSVCSEPAYRLTPSPPKQPSHSPSQGSLPSLNGIMEIAGMDDYALLRQPDGASDPSLPKSEKRFAPQHDDICELDEKAMAAAVGKRNSLEDAQHKLNEITNILPLAAQSRLPLLPLNTSSEAYDSGHDSNSTPRTSKHSGISRRAESGYHSVATVRDSDESSFASGMSKGQRHRITISGGGGGGCGAGGGGSATGNYQRHSHGVGGHKKHRHRHEGNGGGNKGLCNWLLTPFSCTYPETEGEISDF
What are the official names of this protein?
Kinesin-like protein GA13060.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: APA2_KLULA
Sequence: MFPSNLREIVEATYEKAVANGHVKFTESSSKKLKDVDAGISYQVTFAPSLQSKPERLPIAIDENGAPIPKKDPFAEPEPELTILDDCAGDYKLLLNKYPVAANHLILVTKKYLLQTAPLSPKDLLTTYKLLQELDDEDEMLRHLAFYNCGPNSGSSQDHKHLQILPLPYKFVPYQDKLCSGKEHFIPNAKTEPLQDAKIPFAHYAVPLPEDPEKVDEDLLAMTFVSLLQRTLSMFQDWEGSNAEKSNDDEASIPAYNVLMTKEWLCLVPRSKAFAETPSIGFNATGYAGLVLVKWDETLKVLNENPSAVTKLLLECSFPSTAGAKPTEYHY
What is the function of this protein?
Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP.  Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates.  Cannot catalyze the reverse reaction.  Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange reaction between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.
What are the official names of this protein?
Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2, Ap4A phosphorylase 2, ADP-sulfurylase, ATP adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ATP adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HSLO_NOSS1
Sequence: MADQLIRATAADGGIRAVGVITTRLTEEARQRHKLSYVATAALGRTMAAGLLMASGMKRVGSRVNVRVKGDGPLAGILVDAGLDGTVRGYVGNPHIELPPNAKGKLDVGGAVGNGYLYVVRDIGYGYPYSSTVELVSGEIGDDVAHYLVTSEQTPSALMLGVFVGASGVTAAGGLLVQVLPKAARDEALVAKLESRVGALSGFTPLLQAGKTLPEIFHDLLGDMGLTIFPESQILRFHCGCSFDRVLGALKMLGEAELQDMIVKDDGAEATCDFCGRVYQASSEHLAQLIVDLQTESSVSG
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TETM_STRLI
Sequence: MRTLNIGILAHVDAGKTSLTERLLFDHGAVDRLGSVDAGDTRTVDGGIERRRGITIRSAVAAFTVGDTRVNLIDTPGHSDFVAEVERALEVLDGAVLLLSAVEGVQARTRVLMRALRRLRLPTIVFVNKIDRAGARTDGLLGDVRRLLTPHVAPLTEVADAGTPRARVTRRPPDGRTAEALAEVDTEVLAALVDGPEPTGEDVARALAARTADGSFHPLYHGSALGGQGVAELVEGLLGLIPAATPGTSGGTSGGTEPRGTVFAVRPGPAGERTAYLRLYGGEVHPRRRLTFLRRESDGRTTEVSGRVTRLDVVGGDATLTAGNIAALTVPGGLRVGDRLGGPTDRAPQFAPPTLQTLVRARHPEQAAPLRSALLALADQDPLLHARPAASGATALLLYGEVQMEVLAATLAEDFGIEAEFTPGRVRFLERPAGTDEAAEEMPWLDRTRYFATIGLRVEPGPRGSGGAFGYETELGALPRAFHQAVEETVHDTLRTGLTGAAVTDYRVTLIRSGFSSPLSTAADFRGLTPLVLRRALARAGTVLHEPYQAFEAEVPADTLAAVTALLASLGADFTGTTGGDPAWIVTGELPARRVREAELRLPGLTHGEAVWSSRPCEDRPLKAGNSGPGTGVGGHSGE
What is the function of this protein?
Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.
What are the official names of this protein?
Tetracycline resistance protein TetM.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. TetM/TetO subfamily.
Protein: ISPE_RHOBA
Sequence: MTESRWYSTSPPAKLNLFLELLARRDDGFHELDTVMVAIDWRDELHVRRTTNPGVQLSVDWTDGRTSVAAELQVDEDNELLLVPTDDKNLVVRALNRLTETLRLDGGWEVQLNKNIPSGAGMGGASSDAASALQLGWAAARETQSDLPETLKNETLLSLAAEIGSDVPFFLGDLQADRLVQCAHATGRGEKLNFFTLANPLHAVVIYPAASVSTAQVYSRCQVPDSPQSSNELLRALQGIAAESEFSLHNALQAPARGLSSRIDPALECLSKAGLTHCHMTGSGSACFALADSSQQAAIAAETLRSTFPGGALIRPVMSCVVPSEIHIA
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: B2LA1_HUMAN
Sequence: MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
What is the function of this protein?
Retards apoptosis induced by IL-3 deprivation.  May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).  Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).
What are the official names of this protein?
Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y295_MYCPN
Sequence: MNNTKNKSDWQLFLEDYRFYHEKEFDWITYLNHCLNSYPDFDILKFIRKYGPECEKSFLSLQSKTKADVYGVFTKQIKAGSVNEVLAQKLVQLDALRTNYLIGALYSTNKTQKKLFKQSWKNAKKQGYTKQEWLMTLVGLPFEKGEYHKQLYAHSRQEILDLVEAVKKLYLRPEKDDKLEFADSSKVSESKSIKVTNAVTLPSDDLDKELFEFSGEGGDE
What are the official names of this protein?
Uncharacterized protein MG210.1 homolog.
Protein: TRMD_PORG3
Sequence: MRIDIITVLPEMIENTLNCSIIGRAQERGLLELKLHQLRDYSTDKWKRVDDYPFGGEPGMVMQVEPIDRIITELKTQREYDEVIFTSPDGERFDQPMANELSLLSNLIILCGHYKGIDYRIREHLITREISIGDYVLTGGELAAAVMTDAIARLIPGVLNDAGSALSDTFQDNLLAPPVYTRPAEYKGWRVPDILLSGHEANIAKWRLEQAVERTKRLRPDLIKD
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_BAUCH
Sequence: MKNVTVKSLAVEMQISVDHLVQQFSNVGFHKTARDYVTQQEKETLLAYLKYELSNTPLTLQRKTRSTLNIASTSGRSKSVQVEVRKKHIYIQPVAHDSILTIKENILPNNTQEVKNNAEASPKTKFILTPKQQSKIAKNNIVNNQNNLIKKSRQISEKAILEAKAAELKHQAEEETRRKVEEKARQIAEEARQFAEHNDSIWMTTPELAEDDTIDDNLSNYHYASIVEDENNRKIENERRTRGNKVSKQKTYRLSEFKKNREEARAVGRSSKSQSKRKSSTLMQVFNKPSQVINRDIVIGEMITVAELANKMAVKGSQIIKKLIQLGVMATINQIIDRETAQLVAEDMGHKVILLRENELEESIMKDRKIDSSVDNAESRAPVVTIMGHVDHGKTSLLDYIRSTKVVASEAGGITQHIGAYHVETDRGMITFLDTPGHAAFTAMRARGARTTDIVVLVVAADNGAMPQTIEAIQHAKAAKVPIVVAVNKIDKKEANPENIKNELTKHGIIPEEWGGQNQFVNISAKYGTGINNLLDAILLQAEVLELKAIRNGIASGIVIESFLDKGRGPVATILVREGTLHHGDMILCGLEYGRVRAMRDEQGRHLSTAGPSVPVEILGLSGVPIAGDEAMVVRDEKKAREVALYRQGKFREGKLARKHSAKLENMFTNISEGGILELNIILKTDVQGSVEAINDALEQLSTEKAKVKIIGSGVGGITETDATLAAASNAILIGFNVRADASARRIIDKENLNIHYYSVIYHLINEVTQAMNGMLTPEYKQDIIGLAEVRNVFSVPKFGLIAGCMVIEGIVKRHNNIRVIRNNIIIYEGELYSLRRFKDDVNEVRNGMECGIGVKNYTDIRTGDIIEVFKLIPIIKSSN
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEW22_SCHPO
Sequence: MNDNNSCKLTMLTRRLENMTQEYGQPDLPVPFLNGDEPGKLKLPLSERHEDVDYLTKEQCIQYFNGYSIHLIPPRISS
What are the official names of this protein?
UPF0612 protein new22.
What is the protein family that this protein belongs to?
Belongs to the UPF0612 family.
Protein: EFP_STAA8
Sequence: MISVNDFKTGLTISVDNAIWKVIDFQHVKPGKGSAFVRSKLRNLRTGAIQEKTFRAGEKVEPAMIENRRMQYLYADGDNHVFMDNESFEQTELSSDYLKEELNYLKEGMEVQIQTYEGETIGVELPKTVELTVTETEPGIKGDTATGATKSATVETGYTLNVPLFVNEGDVLIINTGDGSYISRG
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y963_METJA
Sequence: MDKITVEVIKSSTSYIAEEMGIILRNTAYSPNIKDRLDFSCAILSSNGELIAQAEHIPVHLGSMAIGVKNTVDYLKKESIEIEKDDVIIVNDPYIAGTHLNDITLLKPIFYNDEIIGYVANKAHHVDVGGYAPGSISSNVKELYHEGLIIPPSKLVINGKLNKELLNLITSNVRVPKSTIGDLKAQIASLNIGVERILKLIEKYGDREVTEAWNKSLDYSEEYLKSKIRDINCICEAVDYLEYKDKLININMKIEIKNGKIKVDFTGTHRQLDAPLNAVYGVTVASTSFALKAVIDPDLPMNHGIFRVLNIIAPEETIVNPKKPAPVSVGNVETSQRIVDVIFKALYHEFPDRVPAASNGSMNNVIIGGRGWAFYETIGGGFGGRNGKDGVDGVHANMTNTLNTPIEVIENEYPIMILEYSLREDSGGAGKYRGGLGIRRVYKMLSDCMLSIIADRIKISPWGVNNGYSGACGEHYVIKDGKKIPLSGKDTLYLSCGDIVEINTPGGGGYGSPYERDINLILEDVKDEKISIKSAYRDYKVKIIKKDDDFVVDMEETKKLRGL
What are the official names of this protein?
Uncharacterized protein MJ0963.
What is the protein family that this protein belongs to?
Belongs to the HyuB family.
Protein: RPO3_METTH
Sequence: MDIALKEKTDTEMVFVVSGVTVPFINAIRRICMMEVPKLAIEYVNMYRNDAKMFDEVLAHRLGLVPLAADPEFAESLKMPEECDCEEYCSECSVSLTLRKKGPGVVYSGDLVSETPAVKPVYPDIPLVKLGDDDELELEAVAQLGVGREHAKWEPTTACAYKYYPRIEFSEDCDECLECIEACPRDVLGEESGKPVVVDLENCSMCKSCVRACDKRAIDVGYEEGKFIFRIETDGSVDPKDVLLKACDILRDKAEQVITFCEGG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo3, DNA-directed RNA polymerase subunit D.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_RICCN
Sequence: MVDLKTKAFDISQNFTISLDGPAASGKGTIGLILAKKFSLKYFQSSIVYRQLAFDCISQKIDVTDIDAVIALSKELKLDNNFDLENENIGNIASQIAVISEIRNNLNKYLISLVKTTPRMIMEGRDIGTVVAPDADLKIFITANPQIRAERRYKQLQAKGKTCILDEILRQIILRDKRDKERKAAPLLPASDALIIDTSKLSAMEVVEEVTNYIKNKIT
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NC2A_HUMAN
Sequence: MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGARRGRKPGSGGRKNGGMGTKSKDKKLSGTDSEQEDESEDTDTDGEEETSQPPPQASHPSAHFQSPPTPFLPFASTLPLPPAPPGPSAPDEEDEEDYDS
What is the function of this protein?
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes.  This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP.  Can bind to DNA on its own.
What are the official names of this protein?
Dr1-associated corepressor, Dr1-associated protein 1, Negative cofactor 2-alpha, NC2-alpha.
What is the protein family that this protein belongs to?
Belongs to the NC2 alpha/DRAP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEM3_NITSB
Sequence: MKLTIATRGSKLALWQSNHIKAQLESFGYEVELKIFKTKGDKILDTPLALIGGKGLFTKELEDAMLRGEADLAVHSLKDVPTELPEGLVLGAITKREMTNDSLLSEQYETLADLPPNAVVGTTSLRRRMQLLHLRPDICIKDLRGNVDTRINKLKNGEFDAIILAYAGLKRLGILESVRYVHPIDENTMIPAMGQAALGIECRPDVVDVVKKLNDEKSAIETFIERDFIDRLQGGCQVPIGVRASLLENNDIIVKAVIGLPDGSELLKDKIFGSKENYHELGKELAESMIDNGAKELLQRAEAMAFKEHK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: Y6940_STRAW
Sequence: MNRVTPDRPLSRIDGHAHAWTPRKARARFRWGVFGPTAGVAAGHTQANLISLPADWAYDMLLFCQRNPKPCPVLDVTDAGSWTTPLAEGADLRTDLPRYRVWENGELVAEPTDVVAYWRDDLVSFLIGCSFTFEWALSEAGVPMRHIEQGRNVSMYVTSRACRPAGRLHGPMVVSMRPVPPEHLAAAIRESTMLPAVHGSPVHCGDPSGLGIDDLGRPDFGDPVDAEPDDIPVFWACGVTPQAAVMASRPPFAITHAPGQMFLTDARDEQYRVA
What are the official names of this protein?
Putative hydro-lyase SAV_6940.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: SLYA_SALPC
Sequence: MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEDKGLISRQTCASDRRAKRIKLTEKAEPLIAEMEEVIHKTRGEILAGISSEEIELLIKLVAKLEHNIMELHSHD
What is the function of this protein?
Transcription regulator that can specifically activate or repress expression of target genes.
What are the official names of this protein?
Transcriptional regulator SlyA.
What is the protein family that this protein belongs to?
Belongs to the SlyA family.
Protein: TRIB1_MOUSE
Sequence: MRVGPVRFALSGASQPRGPGLLFPAARGTPAKRLLDTDDAGAVAAKCPRLSECSSPPDYLSPPGSPCSPQPPPSTQGTGGSCVSSPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKEFPIKHYQDKIRPYIQLPSHSNITGIVEVLLGESKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLRREPSERLTAPQILLHPWFEYVLEPGYVDSEIGTSDQIVPEYQEDSDISSFFC
What is the function of this protein?
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:23515163, PubMed:20410507).  Promotes CEBPA degradation and inhibits its function (PubMed:20410507).  Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (PubMed:24003916, PubMed:23515163).  Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (PubMed:23515163).  Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (By similarity).
What are the official names of this protein?
Tribbles homolog 1, TRB-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Protein: LMBL1_CHICK
Sequence: MDGRAEMEVVRTTKGNAAGEVSVHVVTTESTVQSTHLPTTAFIFPSQANATTINLPTSTLEIQRFPREPPRNTGAERPEKGVGSEPITATVIPQISGVQTCNTVRVLEWKDGVATLPGSNLRFRINEYGTLKVVSADKMPPAEAVKEGHAKKDGDSDVAPTSRDNTIVAQDVPEQSKLPTADSICHCDTCGRRHVSDGAREGRGFCSEHCHQQFKERSVIVENSASSTSATEILKPVKKRKRKDYQSPSEEDYESEQMEEKQEEMKNSVGDSAISNPEAHAWSQHSTEGPGASEEKKEGWSWASYLEEQKAVAAPLDLFQDYQVASQHKNGFKVGMKLEGIDPQHPSMYFILTVAEVCGYRMRLHFDGYSECHDFWLNADSPDIHPAGWFEETGHKLQPPKGYKEEEFSWTNYLKITKAQAAPKHLFVIRNTHEAPPGFEVGMKLEAVDRMNPSLICVATVTDVVDDRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQEHGKPLTPPQDYPDPDNFIWEKYLKETGASAVPAWAFKVRPPHGFLVNMKLEAVDRRTPSFIRVASVEDVEDHRIKIHFDGWSHVYDFWIDADHPDIHPIGWCSKTGHPLQPPLRPKEPASSAHSGCPTLGCKNIPHTKSSKYSFHHRKCPTPGCDGSGHVTGRFTAHYCLSGCPLAEKNQGKLKADLSDTEASTRKRNLIGFPQRKKSRHHGSFRGRPPKYRKIQQEDFQTISSDNMHQSLFMSALSAHPDRSLSLCWEQHCKLLPGVAGITATTVAKWTIDEVFSFVQTLTGCEDQAKLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNADDTLK
What is the function of this protein?
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications.  PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription (By similarity).
What are the official names of this protein?
Lethal(3)malignant brain tumor-like protein 1, H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog.
What are the subcellular locations of this protein?
Nucleus.