PharMolix/UniProtQA huggingface dataset:
Protein: ZBT14_CHICK
Sequence: MEFFISMSETIKYNDDDHKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPEENTQSKSKYCLKINRPIGEPNDTQDDEVEEIGDHDDSPSDVTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETTESKDLGSQTPQALTFNDGISEVKDEQTPGWTTAAGDMKFEYLLYGHREHIVCQACGKTFSDEARLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTTANSIQSETEQLQAAAMAREAEQQLETIACS
What is the function of this protein?
Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'.  Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene.  Transcriptional repressor of MYC and thymidine kinase promoters (By similarity).
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 14, Zinc finger protein 161 homolog, Zfp-161, Zinc finger protein 5, ZF5.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: 3S11_NAJCH
Sequence: MECHNQQSSQPPTTTHCSGGETNCYEKRWHDHRGTIIERGCGCPTVKPGVKLNCCTTDKCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin 1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CP52V_CANAP
Sequence: MIIGLSDAFALGGIALSFLVAYQFIYFYFIYSPRAKKLGCAPPVIVFSFPLGLPALYKFATAMLHDNLLEYISIRIADMKVRTGFQTLAGQRWLVTLEPENIKTVLATSFKDYSLGFRYDIMYGLLGNGIFTLSGDGWKHSRALLRPQFSREQVSHLESMRTHINLMINNHFKGGQVVDAQALYHNLTIDTATEFLFGESTNTLDPDLAQQGLPGPKGLVTGEQFAEAFTSALEILSVRVIVGAAWFLIWTPKFWRSCKVCHNFIDYFVYKALATPMEKDQEADRYVFIRELTKETSDPRVIRDQALNILLAGRDTTAGLLSFITYYLGAYPEVYAELREAVLSEFGSTDVETPTFEQLKQCKVLQNVIREVLRLHPNVPLNFRQAIVDTKLPTGGGPNGDQPVFVPKGQNVFYSTYSMQRRTDIWGPDATTFRPDRWNEPREALASGWDYIPFNGGPRICLGQQFALTEASYTIVRICQEFSRIEVLHPDVITSKNSMKQRMRLTQTASGGVITRFIR
What is the function of this protein?
Together with an NADPH cytochrome P450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.
What are the official names of this protein?
Cytochrome P450 52E1, CYPLIIE1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane. Membrane; Multi-pass membrane protein.
Protein: SECA1_MYCSS
Sequence: MLDKLLRLGEGRMVKRLKKVADYVNTLSDDVEKLSDAELRAKTDEFRKRIDGGEDLDDLLPEAFAVAREAAWRVLSQRHFDVQVMGGAALHFGNVAEMKTGEGKTLTCVLPAYLNALSGKGVHVVTVNDYLAKRDAEWMGRVHRFLGLDVGVILSGLTPDERRAAYHADITYGTNNEFGFDYLRDNMAHRLEDRVQRGHNFAVVDEVDSILIDEARTPLIISGPADAASNWYSEFARLAPLMEKDVHYEVDLRKRTVGVHEVGVEFVEDQLGIENLYEAANSPLVSYLNNALKAKELFQRDKDYIVRNGEVLIVDEFTGRVLLGRRYNEGMHQAIEAKEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVPIPTNRDMIRQDQTDLIYKTEEAKFIAVVDDVYERYEKGQPVLIGTTSVERSEYLSKQFTKRKIPHNVLNAKYHEQEANIIAEAGRLGAITVATNMAGRGTDIVLGGNVDFLADKRLREQGLDPVETPEEYEAAWESTLNQIKAEAEEEADDVRAVGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDELMRRFNGATLEALLTRLNLPDDVPIEAKMVTRAIKSAQTQVEQQNFEVRKNVLKYDEVMNQQRKVIYEERRRILEGEDLAEQAHKMLVDVVTAYVNGATAEGYAEDWDLEQLWTALKQLYPVGIDYHDLVDSDAVGEAGELTREELLDMLIKDAERAYAERERELEELAGEGAMRQLERNVLLNVIDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGYDMFVGMLEALKEESVGFLFNVTVEAAPAAPSNRVAPVAAPPGLSEFAAAAAKAQEQTGQGAVATKERETPAPTLRAKGIDNDDTPPLTYVGPGEDGSAEVQRSNGGPRHAAPGGATRRERREAARKQAKTSKPTRRRG
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 1.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: PKHJ1_HUMAN
Sequence: MRYNEKELQALSRQPAEMAAELGMRGPKKGSVLKRRLVKLVVNFLFYFRTDEAEPVGALLLERCRVVREEPGTFSISFIEDPERKYHFECSSEEQCQEWMEALRRASYEFMRRSLIFYRNEIRKVTGKDPLEQFGISEEARFQLSGLQA
What are the official names of this protein?
Pleckstrin homology domain-containing family J member 1, PH domain-containing family J member 1, Guanine nucleotide-releasing protein x.
Protein: TOLB_XYLFM
Sequence: MTKFPRWLAILVGLLFPLSALTQQQGLTIDIVGGNTAATPIAVLPMPYHDSAGAPATDVSGVVAADLNRSGQFRTLPLGQITERPTHGSEIRFPTWQALKQDYIVVGRVLDARQGTYRVEYELFDVRNGKRMLGLAMTARASAMRDVAHQMADAIYEKITGLRGAFFTRIAYVTASGSHGAMRYALMVADSDGYNPQTIVRSAEPLLSPDWSPDGKKLAYVSFEKGGSSIYIQDIATGSRELVSSFRGINAAPSFAPDGHRIALSLSRSGNPEIYVMDLVSKQLIQLTNSFGIDTEPVWSSDGKFIYFTSDRGGRPQIYKVASVGGTATRVTFQGNYNATASVSYDDKKIVVAQGSGNVYRIAMMDQSSGSTVWNTLSTGSLDESPSFAPNASMVLYAAREGGRGVLYAVSADARVRQRLVSVDSDVREPAWGPYRSVH
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: UBID_NEIMA
Sequence: MKYKDLRDFIAMLEQQGKLKRIAHPVSPHLEMTEIADRVLRAEGPALLFEHPVKPDGTRYDYPVLANLFGTPERVAMGMGADSVSKLREIGQTLAYLKEPEPPKGIKDAFSKLPLLKDIWSMAPNVVKNAPCQEIVWEGEDVDLYQLPIQHCWPEDVAPLVTWGLTVTRGPHKKRQNLGIYRQQLIGINKLIMRWLSHRGGALDYQEFRKLNPDTPYPVAVVLGCDPATILGAVTPVPDTLSEYQFAGLLRGSRTELVKCIGNDLQVPARAEIVLEGVIHPNETALEGPYGDHTGYYNEQDHFPVFTVERITMRENPIYHSTYTGKPPDEPAVLGVALNEVFVPLLQKQFPEITDFYLPPEGCSYRMAVVSMKKQYAGHAKRVMMGCWSFLRQFMYTKFIIVVDDDVDVRDWKEVIWAVTTRMDPVRDTVLMENTPIDYLDFASPVSGLGGKMGLDATNKWPGETDREWGRVIKKDPAVTAKIDEIWEELGL
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CCA_STAES
Sequence: MSHEIFEQAKPILKKIQNKGFKAYFVGGSVRDYIMQRPIHDVDITTSATPDEIESIFDKTIPVGKEHGTINVVFQNDNYEITTFRSEDEYIDHRRPSEVYFVRDLYQDVQRRDFTMNAIAMDLNYRLYDYFNGQQDINNRVIRTVGVPSERFSEDALRIIRGLRFQSQLNFQIDSDTLHAMSSQISDIQYLSVERVVVELKKLIMGNNVKQSFEVMQNMKAFNYIPFFKSFEMSHLHIDEPITFELWIAILIVQQPKDIQLSTLKISNQEKATIKKWVTLIQTLPKIQSKQSLITLVYDYNLNDIEILLSLHHLLKQNGLTTANHLIINEISIREANEKLPIHCRKELAINGKDILNHTNKNSGPWLKDTLREIEIAVISNQIVNTKEEILEWVDAHVKI
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: GATB_SYNP6
Sequence: MTATAPVKTEYEAVIGLETHVQLGTATKIFSNASTEFGADPNTHIDPVVLGLPGTLPVLNQKVLEYAVKAGLALNCQIAPYSKFDRKQYFYPDLPKNYQISQYDLPIAEHGWIEIEVAEKGKEPYTKKIGVTRLHMEEDAGKLVHAGSDRLAGSTHSLVDYNRAGVALAEIVSEPDLRTGKEAAEYAQELRRIMRYLGVSDGNMAEGSLRCDVNISIRPKGTEKFGTKVEIKYMNSFNAIQRAIEFEIERQIRCLETGEPIVQETRLWDEGKQVTKSMRSKEGSSDYRYFPEPDLGPIEVSETQRETWRSELPELPAQKRHRYAEQYGLSAYDARVLTDEKSTADYYEATVAAGADAKQAANWLMGDIAAYVNANKLLVSDLPLQPQDLAELVNLIEAGTISGKIAKEILPELLEKGGSPKAIVEAKGLTQISDPAQIEALVDELLAAHPTELEQFRAGKTKLQGFFVGQLMKKTGGRVDPKLSNQILNQKLKG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: SMG_SHESW
Sequence: MFDILMYLFENYVHSEVELLVDEDELTKELTRAGFHQSEILKALTWLERLAELQEGDKPYLCNHDQHSFRIYTKDEMDKLDVESRGFLLFLEQVKVLNVETREMVIDRVMELDEPTLILEDLKWVILMVLFNAPGHESAYEQMEDLIFEQPEGRLHS
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: RL7_STRSY
Sequence: MALNIENIIAEIKEATILELNDLVKAIEEEFGVTAAAPVAVAAAGGAAEEAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPAMVKEGVATAEAEEIKAKLEEAGASVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RSMA_BORPE
Sequence: MSAHQARKRFGQHFLTDESVVESIVRAIGPARDDRVVEIGPGLSALTRPLLDRIDHLTAVEIDRDLAARLRRQYPAERLTVVEADALTVDFAQFGQGLRVVGNLPYNISSPLLFHLMGAAEQVRDQHFMLQREVIDRMVAEPGSGDYSRLSVMLQARYRMEKLFDVAPEAFDPPPRVVSAVVRMAPLPADRLRPASDAAFETVVARAFSQRRKMLRRVLDDWAALTPWDELGIAPTARAEEVGVAQFIGLADALLAAGAPGLARP
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_GEODF
Sequence: MKITRRPEWLQKKVSPAAHADMERLLGGLQLHTVCQEAHCPNISECFRQRQATFLILGKLCTRLCSFCNVTKQTPLAVDQAEPERVAAAVELLKLTHVVVTSPTRDDLADGGAALYAATVAAIRNASPQTKIELLVPDFAGNQESIAAVVSACPHILGHNLETVPRLYSIRSGADYRRSLLMLEMIRRLNPAMKTKTGLMLGLGETEEELFQALRDLRRVDCSYLSLGQYLAPSRSHYPVQDYPSPETFDRYREQALSMGFEHVESGPYVRSSYHAEHYGTGTGHAKLSPAPAD
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_STRPM
Sequence: MIKIYDTMTRSLRKFVPLTENTVNMYVCGPTVYNYIHIGNARSAVAFDTIRRYFEYTGYQVNYISNFTDVDDKIIKAATQAGVSPKELSDRFIAAFIEDTKALGVKPATQNPRVMDYIAEIISFVESLIEKDFAYEADGDVYFRVEKSEHYAKLANKTLSELEVGASGRTDAETALKENPLDFALWKSAKAGEVSWDSPWGFGRPGWHIECSVMATEILGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKTFANYWMHNGFVTVDNEKMSKSLGNFVTVHDMLQTVDGQVLRFFLATQQYRKPINFTEKAIHDAEINLKYLKNTLQQPLTETADEQELKQFVIAFQDAMDDDFNTANGITVVFDMAKWINSGSYTEPVKSAFEKMLAVFGIIFEEEVLEVDIEALIAKRQEARANRDFAIADAIRDQLAAQGIKLLDTKDGVRWLRD
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL352_ARATH
Sequence: MARIKVHELREKSKADLSGQLKEFKAELALLRVAKVTGGAPNKLSKIKVVRKSIAQVLTVISQKQKSALREAYKNKKLLPLDLRPKKTRAIRRRLTKHQASLKTEREKKKEMYFPIRKYAIKV
What are the official names of this protein?
60S ribosomal protein L35-2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: SSPC_STAA8
Sequence: MYQLQFINLVYDTTKLTHLEQTNINLFIGNWSNHQLQKSICIRHGDDTSHNQYHILFIDTAHQRIKFSSIDNEEIIYILDYDDTQHILMQTSSKQGIGTSRPIVYERLV
What is the function of this protein?
Specifically inhibits the cysteine protease staphopain B (SspB) by blocking the active site of the enzyme.  Probably required to protect cytoplasmic proteins from being degraded by prematurely activated/folded prostaphopain B.  Also involved in growth capacity, viability and bacterial morphology.
What are the official names of this protein?
Staphostatin B, Staphylococcal cysteine protease B inhibitor.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I57 (SspC) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRP_MUSCA
Sequence: SPVAASYRATAGLAGKALDF
What is the function of this protein?
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine.
What are the official names of this protein?
C-reactive protein.
What is the protein family that this protein belongs to?
Belongs to the pentraxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATAB2_ARATH
Sequence: MATLGFNTRRIQTPSLPRIPKPSSFTKPIKTHHLFSSETLLKRCRFVSRSLPESSLSITKEQEVANEVEEDDPTSELSYLDPESDADSIKEWELDFCSRPILDSRGKKIWELVVCDASLSLQVTKYFPNNVINSITLKDAIVTITQDLGVPLPEKIRFFRSQMQTIITKACKELAIKAVPSKRCLSLFLWLQERYDTVYTRHPGFQKGSLPLLSLDNPFPMNLPENLFGEKWAFVQLPYSAVREEISDFDEKFVFGASLDLDLLGIEVDENTLIPGLSVATSRAKPLAAWMNGLEVCSIEADSSKGCLILSVGIATRYVYATYKKTPVTTDEAEAWESAKKTSGGLHFLAIQDDLDSDDCVGFWLLIDLPPPPV
What is the function of this protein?
Nuclear genome-encoded A/U-rich RNA-binding protein involved in the biogenesis of photosystem I (PSI) and II (PSII).  Required for the light-controlled accumulation of PSI and PSII during early plant development (PubMed:17139246).  Does not seem to be required for the translation of mRNAs of the PSI subunits (PubMed:25725436).
What are the official names of this protein?
Protein TAB2 homolog, chloroplastic, Protein ATAB2.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FOLD_SHIF8
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDALNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: UNG_PSEF5
Sequence: MTADDRIKLEPSWKEALRAEFDQPYMSELREFLRQEHAAGKEIYPPGPMIFNALNSTPLDKVKVVILGQDPYHGPGQAHGLCFSVQPGVPAPPSLVNIYKELKRDLNIDIPNHGYLQSWAEQGVLMLNTTMTVERANAASHAGKGWQFFTDRIIEVVSEHQPHLVFLLWGAHAQSKQKLIDATKHLVLTSVHPSPLSAYRGFLGCGHFSRTNKYLEQNGETPIEWRLPPL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2Y14_BOVIN
Sequence: MNATSVPPAEGSCPSNALITKQIIPMLYFVVFVAGILLNGMSGWVFFYVPSSKSFIVYLKNIVIADFLMSLTFPFKILGDLGLGLWQVKVFVCRVSAVLFYINMYVSIVFFGLIGFDRYYKIVKPLLTSFIQSISYSKLLSVLVWSLTLLIALPNMILTNRNVTEATRVKCMDLKSDLGLKWHKASSYIFVGIFWIVFLSLIIFYTAITKKIFKSHFKSRKNSVSVKKKSSRNIFSIMFVFFICFVPYHIARIPYTQSQTEAHYSCQSKQILFYVKEFSLLLSAANVCLDPIIYFFLCQPFREVLCKKLHIQLKTQHDSETSKIKRENIIQESTDTL
What is the function of this protein?
Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins.  Not activated by ATP, ADP, UTP or ATP (By similarity).
What are the official names of this protein?
P2Y purinoceptor 14, P2Y14, UDP-glucose receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDE4E_DROME
Sequence: MLNKNSASSQSLPRVHSFFNMIPSIMQDDLALTILNDRDNMFSIKSQRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGGGGMAPRTGGCQNQPQHGGM
What is the function of this protein?
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity).  Vital for female fertility.  Required for learning/memory (By similarity).
What are the official names of this protein?
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, Learning/memory process protein, Protein dunce.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Protein: LEUC_DESVM
Sequence: MAHTLAQKILQAHTDEAITAAGQIVRCRVSLALANDITAPLAIKSFRAMGAKKVFDRDKVALVMDHFTPQKDIASAQQVKLTREFAREMGVTHYYEGGDCGVEHALLPELGLVGPGDVVVGADSHTCTYGGLGAFATGFGSTDVAGAMALGETWFKVPPTIRATFTGTLPKWVGAKDLILRLIGEIGVDGALYRALEFDGAAIEALSVEGRMTIANMAIEAGGKAGLFAADAKTLAYTAARGRKDAPLSADPGATYERELTFDVSGMEPLVACPHLPENVKPVGEVRGVTLDQVVIGSCTNGRISDMREAAEVLKGRKVAKGVRCIVLPATPGVWKEALKEGLIETFMESGCIVGPATCGPCLGGHMGILADGERAIATTNRNFRGRMGSLESEVYLASPAVAAASAVAGIIAHPGSL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: SMYD2_MOUSE
Sequence: MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVLGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEVRKLSSPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
What is the function of this protein?
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1.  Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo.  The activity requires interaction with HSP90alpha.  Shows even higher methyltransferase activity on p53/TP53.  Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53.  Monomethylates RB1 at 'Lys-860'.
What are the official names of this protein?
N-lysine methyltransferase SMYD2, Histone methyltransferase SMYD2, SET and MYND domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: DXR_BACP2
Sequence: MRYISLLGATGSIGEQTLDVIRQHPDKFKLKAMTFGRNVDKAIPIIEQFQPEFVGCLSEEAYHTLKGHSFEYDVKMAAGDEANIEAAIYDAVDVVVNALVGSVGLVPTLKAIEQKKTIALANKETLVTAGHIVKEYAKTYDVPLLPVDSEHSAIFQCLQGEQAKNIERLIVTASGGSFRDKKRTELEGVTVEEALNHPNWSMGAKITIDSATMMNKGLEVIEAHWLFDIPYEQIDVLLHKESIIHSMVEFHDKSVMAQLGTPDMRVPIQYALTYPDRAPLPEAKSLNLWEIGQLNFQKADFDRYRCLHFAYESGKIGGTMPAVLNAANEMAVDAFLKGKVTFLQIEELIEKALNRHHVISTPSLQDIHEVDKETRDFVQSILT
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: COX2_CRACA
Sequence: MAYPMQLGLQDATSPIMEELTDFHDHTLMIVFLISTLVLYIISLMLTTKLTHTNTMDAQEVETVWTILPAIILIMIALPSLRILYMMDEINDPYLTVKTMGHQWYWSYEYTDYEDLMFDSYMIATSDLKPGGLRLLEVDNRVVLPMELPVRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQATLISSRPGLYYGQCSEICGANHSFMPIVLEMVPLKQFESWTSSMT
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SUCR1_RAT
Sequence: MAQNLSCENWLALENILKKYYLSAFYGIEFIVGMLGNFTVVFGYLFCMKNWNSSNVYLFNLSISDLAFLCTLPMLIRSYATGNWTYGDVLCISNRYVLHANLYTSILFLTFISIDRYLLMKFPFREHILQKKEFAILISLAVWVLVTLEVLPMLTFITSTPIEKGDSCVDYASSGNPKYSLIYSLCLTLLGFLIPLSVMCFFYYKMVVFLKKRSQQQATVLSLNKPLRLVVLAVVIFSVLFTPYHIMRNVRIASRLDSWPQGCSQKAIKCLYILTRPLAFLNSAVNPIFYFLVGDHFRDMLFSKLRQYFKSLTSFRL
What is the function of this protein?
Receptor for succinate.
What are the official names of this protein?
Succinate receptor 1, G-protein coupled receptor 91.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.