PharMolix/UniProtQA huggingface dataset:
Protein: MPS2_YEASV
Sequence: MSNGAFDAIFEYAWGQIDKPISGDFIYGKDLPKLIEIIENIFQKAQKSGSYELRLPLFSEINKDLFRTFSNTKTFFKIHKEEFDDIFFNLVNHPLREILENAFIGVDSIPSDFIVSMNLNSPSKFLVENKSKNTEGAGISTPRKKLTESPIKLLSRNNIGKALEVQVEELKRELTAKQSLLQENERQVSELKIRLETYQEKYASIQQRFSDLQKARQVEDNQNSSRTSDPGSPLVTGIDQKAILEEFRRRLQRQTDTISFLKDQIRRERGLNCSNDKVSHSKRKHATTDGDGTFKNFISAVPSNIWVKATIRIIVCFALLAGVLPYIRKYVYAHDTPSQNSRLQLSWWENSGILSKIVWFFEDQTDLETEYRSNANVDDAYSRVFGI
What is the function of this protein?
Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.
What are the official names of this protein?
Monopolar spindle protein 2.
What is the protein family that this protein belongs to?
Belongs to the MPS2 family.
What are the subcellular locations of this protein?
Nucleus membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: VPS51_CHICK
Sequence: MAEVEAAGSGTETGGGSESGNATGSGSGWRRPHGPLQRYYGPSAAEAAEATPDPADINGPHFDPEVFLTKVRSECRLGELLSREATLGREIRALDSDMQTLLYENYNKFISATDTIRKMKVDFRRMEAEMDDLASNMAAISASSARVSAALQDRHRRGAQLAGVQALLRKLQSLVEVPGRLRRWAAPGADPARALHCYARARAVLRHYRHLPSFRAIEDESHSIMAELAQRLRARLRDDTLDPKELTECVEMLLQLEEPPEELCEEFLSQAGARLEAELAALEAELPPSDPSGTASTPPPASDILDFVDRGSSAFVSNLCLLAASYRSLFEGRPGSGDGRLEAFASTLTTRYFELLERRLALERGLGDTSLLVRALDRFHRRLRALLELLPAAGAEAGAALVARAARERVARYLRALQTFFLGCLGDVRQALAAPRPPGKDGPGLPDLLATLSSSVLGQLKAVLAYVQLFTARDVAFASLPYFKGEFCVEAVREGLVVAFVRWLCRTARGFADSPAERGAPAAPPALLLLLARLCLDYEATTISYILTLTDEQFPPEDTGPAVTPGPALCAEARGAAQRLLDHYVQVQGAAVAQMLRKSVETRDWLGTVEPRNVRAVMKRVVEDITAIDVQVGQLFEEGVRRAQSSDSSRRAFSVYSSSRAPGRYAPSYTPSAPMDTHLLSNIQKLFSERIDIFSPVEFNKVSVLTGIIKISLKTLLECVRLRTLGRFGLQQVQVDGHYLQLYLWRFAADERVVQGLLDEVAASAAHRCLDPVPMEHSVVELICERG
What is the function of this protein?
Involved in retrograde transport from early and late endosomes to the late Golgi.  The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy.  Acts as component of the EARP complex that is involved in endocytic recycling.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 51 homolog, Protein fat-free homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS51 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Protein: PLSY_HAEDU
Sequence: MTLTAYLLILTAYLLGSICSAIIFCRLAGLPDPRQNGSHNPGATNVLRNGGKLAAIGVLLFDTLKGSLPVLIAFRCDLSPSAIGLIGLAACLGHIFPIFFQFRGGKGVATAFGVFFSISIIASTTMICAWLIVFLLTRFSSLSAVIMALTAPFYIWCFKPEFTFPVALICCLLIYRHHDNIQRLWRGQEERLWDKLKSK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CRVP_LATSE
Sequence: MIAFIVLLSLAAVLQQSSGTVDFASESSNKRENQKEIVDKHNALRRSVRPTARNMLQMEWNSDAAQNAQRWADRCSFAHSPSHLRTVGKFSCGENLFMSSQPYAWSRVIQSWYDENKNFIYDVGANPPGSVIGHYTQIVWYKSHLLGCAAARCSSSKYLYVCQYCPAGNIIGSIATPYKSGPPCGDCPSACVNGLCTNPCKHENEFTNCQSLVKQTGCQNTWIQSKCPASCFCRTEII
What is the function of this protein?
Blocks contraction of smooth muscle elicited by high potassium-induced depolarization (PubMed:12047379).  May target voltage-gated calcium channels (Cav) on smooth muscle.
What are the official names of this protein?
Cysteine-rich venom protein latisemin, CRVP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTWC_STRCO
Sequence: MSTATDTAAPAKKRGSGLFQGLQKVGRSLQLPIAVLPAAGIMVRLGQDDIFGKDGLGWDKVAAVFNNAGGALTGSLPILFCIGVAIGFAKKADGSTALAAVVGFLVYSKVLEAFPVTEAVVQDGADVAATYNDPGVLGGIIMGLLAAVLWQRYHRKKLVDWLGFFNGRRLVPIIMAFVGIVVGVFFGLVWEPIGDGISNFGEWMTGLGSGGAALFGGVNRALIPVGMHQFVNTVAWFQLGDFTNSAGDVVHGDITRFLAGDPSAGIFQAGFFPIMMFGLPAAALAMAHTARPERRKAVLGMMISLAATSFVTGVTEPIEFSFMFIAPVLYVLHAVLTAISMAITWGLGVHAGFNFSAGFIDYALNWHLATKPWLIIPIGLVFAAIYYVTFRFAIVKFNLKTPGREPEEEVEDLTKA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in N-acetylglucosamine (GlcNAc) transport (PubMed:16925557, PubMed:20487300).  High-affinity permease, which exhibits a narrow specificity for GlcNAc (PubMed:20487300).  Essential for C-signaling between vegetative growth and development (PubMed:20487300).
What are the official names of this protein?
PTS system N-acetylglucosamine-specific EIIC component, PTS system GlcNAc-specific EIIC component, GlcNAc-specific transporter, N-acetylglucosamine permease IIC component, GlcNAc permease IIC component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRH_SALTI
Sequence: MATNAKPVYKRILLKLSGEALQGTEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDNYSWAEAISLLRNNRVVILSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPAKDPSATMYDQLTYSEVLDKELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEN5_ARATH
Sequence: MWRLRIGAEARQDPHLFTTNNFAGRQIWEFDANGGSPEELAEVEEARLNFANNKSRFKASPDLFWRRQFLREKKFEQKIPRVRIEDAEKITYEDAKTALRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGHLEKIFTLEHVKELLRYMYNTQNEDGGWGLDVESHSVMFCTVLNYICLRILGVEPDHDGQKSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINGGTLWIYIRDLLMGMSYLYGKKFVATPTALILQLREELYPQPYSKIIWSKARNRCAKEDLLYPKSFGQDLFWEGVHMLSENIINRWPLNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVEDPDGDYFKKHLARVPDFIWIAEDGLKFQLMGMQSWNAALSLQVMLAANMDDEIRSTLIKGYDFLKQSQISENPQGDHLKMFRDITKGGWTFQDREQGLPISDGTAESIECCIHFHRMPSEFIGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVEQEYLECTGSVIAGLVCFKKEFPDHRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSEAIRRAVQFILNTQNAEGGWGESALSCPNKKYIPSKGNVTNVVNTGQAMMVLLIGGQMERDPSPVHRAAKVLINSQLDIGDFPQQERRGIYMNMLLHYPTYRNMFSLWALALYTNALRLLVS
What is the function of this protein?
Converts oxidosqualene to marneral.
What are the official names of this protein?
Marneral synthase, AtMRN1, Pentacyclic triterpene synthase 5, AtPEN5.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: Y2326_MYCBO
Sequence: MSHDIATEEADDGALDRCVLCDLTGKRVDVKEATCTGRPATTFEQAFAVERDAGFDDFLHGPVGPRSTP
What are the official names of this protein?
Uncharacterized protein Mb2326c.
Protein: CRBG1_HUMAN
Sequence: MEKRSSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPNHFNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRLEKSALFSSLLSSLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNSLKVFNFNSSSTSHSSLKSPSHMEKYPQKEKTKEDLDSRSNLHLPETKFSELSKLKNDDMEKANHIESVIKSNLPNCANSDTDFMGLFKSSRYDPSISFSGMSLSDTMTLRGSVQNKLNPRPGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEEAYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHYPCLSAMGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCRQIGSLRPFVQKRIYFRLRNKATGLFMSTNGNLEDLKLLRIQVMEDVGADDQIWIYQEGCIKCRIAEDCCLTIVGSLVTSGSKLGLALDQNADSQFWSLKSDGRIYSKLKPNLVLDIKGGTQYDQNHIILNTVSKEKFTQVWEAMVLYT
What is the function of this protein?
May function as suppressor of malignant melanoma.  It may exert its effects through interactions with the cytoskeleton.
What are the official names of this protein?
Beta/gamma crystallin domain-containing protein 1, Absent in melanoma 1 protein.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: METK_CITK8
Sequence: MAKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHAEEIDQKSLQEAVMEEIIKPILPSEWLNASTKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGREHFPWEKTDKAQLLRDAAGLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_CLOB1
Sequence: MNISIISVGKIKEKFLKAAIDEYSKRLSKYCKLNIIEVADEKTPDNASLKEENIIKEKEGNLILKHIKDNSFVIALDLKGKSITSEEFSDLIENCRLTGNSTIAFVIGGSLGLSQQVLSRANYKLSFSKMTFPHQLFRVMLLEQVYRAFRILCREPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_PARMW
Sequence: MSAAALKVTTESRPGSRLAVTVTVPAERTKTSYEDAINSLSRSINLPGFRKGKVPRTVVIQQLGAVRIKASALETMVDGAWRDAIQQESLEPISQPELSGGFEGLLDSFTPGEAVTITLEADVAPTPKLKSTKGLKASFEPVAYDAAKVDEMLEDSRKQLATVVPVEGRAAEQGDIAVLGFKGTYSDDGSEIEGGSADSMDVDLEHGRMIPGFIEGVIGMAVGDSKTVDCQFPDDYPKEDARGRKAAFEIELKDLKTRELPELNDAFAKQASEQETLAELRQELEQRLKDDAERRQTSNRRDALIGALVEQLEVELPEALIQQESRNLLEQTAAQFAQQGMDVKSLFTPDLVRNLMQNSRPEAEERLRRSFALTALAEAEGISVEDDAVDAKIKEVKKELAADAKIDPQRLRQAVMDDLIQEQLMSWLEENSTLTEQAPAADDADDAEKPAAKKKPAAKKKTPAKSKTDAEA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RUVC_ECO81
Sequence: MAIILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: TRPD_BACC2
Sequence: MNNYLRKLVEGQHLTEEEMYKAGLLLLSENILESEIAAFLVLLKAKGETAEEIYGLVRALREKALPFSNHIQGAMDNCGTGGDGAQTFNISTTSAFVLAGAGVKVAKHGNRAVSSKTGSADLLEELGVNISSTPNEIDYLLEHVGIAFLFAPAMHPALRRIMKIRKELNVPTIFNLIGPLTNPVNLETQFVGIYKRDMLLPVAQVLQKLGRKQALVVNGSGFLDEASLQGENQVVLLKDNEIVEMNIDPENYGFSRVKNEEIRGGNSQENAKITVGVLSGEKSVYRDTVLLNAGLALFANGKTETIEEGIKLATHSIDSGKALTKLNLLIAASNEKLERVN
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RL31_DESVM
Sequence: MKENIHPTTFKAKMTCACGYEAEALSTKGEVVNVEICSQCHPFYTGKQRFVDTAGRIDRFRKKYAKFGEGK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: T2R40_PONPY
Sequence: MATVNTDATDKDISTFKVTFTLVVSGIECITGILGSGFITAIYGAEWARGKTLPTGDHIMLMLSFSRLLLQIWMMLENIFSLLFRIVYNQNTVYILFKVITVFLNHSNLWFAAWLKVFYCLRIANFNHPLFFLMKRKIIVLMPWLLRLSVLVSLSFSFPLSRHVFNVYVNSSIPISSSNSTEKKYFSETNMVNLVFFYNMGIFVPLIMFILAATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIKATSYFLILYIFNAIALFLSMSNIFDTYSSWNILCKIIMAAYPAGHSVQLILGNPGLRRAWKRFQHQVPLYLKGQTL
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 40, T2R40.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS8_ALIFM
Sequence: MSMQDPISDMLTRVRNGQSANKVAVKMPSSKLKVAIAALLKAEGYIADFAVEGDIKPELEITLKYFQAKPVIEQIQRVSRPGLRVYKKNDALPSVMGGLGIAVVSTSKGLMSDRAARKAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: QUEC_PHOLL
Sequence: MRRAVVVFSGGQDSTTCLIQAINQYDEVHCVTFDYGQRHRAEIDVARNVSHFLGVVAHKVLDVTLLNELALSSLTRDNIPVPDHSESEKSAIPSTFVPGRNILFLTLAAIYAYQVEAEAVITGVCETDFSGYPDCRDEFVKALNKAVSLGIARDIRFETPLMWLNKAETWALSDYYQHLDFVRSQTLTCYNGIQGNGCGTCAACHLRANGLEQYLNAPEKIMTEMKAKTHLV
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: VL1_HPV26
Sequence: MALWRTSDSKVYLPPTPVSRVVNTDEYVTRTGIYYYAGSSRLLTLGHPYFSIPKTGQKAEIPKVSAYQYRVFRVHLPDPNKFGLPDPQLYNPDTERLVWACVGVEVGRGQPLGIGLSGHPLFNKLDDTENSHLATVNADTDNRDNVSVDNKQTQLCIIGCTPPLGEHWGIGTICKNTQTQRGDCPPLELISSIIEDGDMIDTGFGAMDFTALQATKSDVPIDISQSTCKYPDYLKMSADTYGNSMFFFLRREQLFARHFYNKAGAVGDAIPTTLYIKGAESGREPPTSSIYSATPSGSMVTSDAQLFNKPYWLQRAQGHNNGICWGNQLFVTCVDTTRSTNLTISTLSAASASTPFKPSDYKQFIRHGEEYELQFIFQLCKITLTTDVMAYIHLMNASILEDWNFGLTLPPTASLEDAYRFIKNSATTCQRNAPPVPKEDPFQKFKFWDVDLKEKFSIDLDQFPLGRKFMLQAGIQRRPKLGTKRPLSSTSSSTKRKKRKLTK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: FTHS_ACTP7
Sequence: MKSDVEIAQAATMQPIHKIAEKLGLNADQIEQYGKYKAKINPTDAFKLPAKNGKLILVTAINPTPAGEGKTTVTIGLTDALNQLGKNAVVAAREPSLGPVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAITSANNLLAALLDNHIYQGNALNIDTKRVLWRRVIDMNDRQLRNVLGGLGNPTDGVIRPDGFDITVASEVMAIFCLAKDLADLKTRLGNILVAYTKDKQPVYAKDLNAHGAMAALLKDAIKPNLVQTIEGSPAFIHGGPFANIAHGCNSVTATRLALHLGDYAVTEAGFGADLGAEKFCDIKCRLADLKPDVAVVVATVKALKYNGGVEKANLAEENLTALQQGLPNLLKHISNLKNVFGLPVVVALNRFVSDTDAELALIQTACAKQGVEVSLTEVWGKGGAGGVDLAQKVLKAIDEQENRFNFVYDVNESVQNKIKAIAQKIYGADDVNFSAEALAEIKNLEKLGLDKLPICMAKTQYSLSDNAKLLGCPSGFTVTVRSISVSAGAGFIVAICGSIMRMPGLPKVPAANRIDVDENGLITGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: WNT5A_HUMAN
Sequence: MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEANSWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Can activate or inhibit canonical Wnt signaling, depending on receptor context.  In the presence of FZD4, activates beta-catenin signaling.  In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity).  Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation.  Stimulates cell migration.  Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754).  Mediates motility of melanoma cells (PubMed:17426020).  Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle.  Inhibits type II collagen expression in chondrocytes (By similarity).
What are the official names of this protein?
Protein Wnt-5a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: MTNC_PSEPF
Sequence: MSIKVILTDIEGTTSAVSFVFDVLFPYAAKHLPDFVRQNAQRADVAEQLDAVRRDSNEPQADVERVVEILLAWIAEDRKATPLKALQGMVWEQGYQAGQLKGHVYPDAVEALQRWHQAGYQLFVYSSGSIQAQKLIFGCSEAGDLTPLFSGYFDTTSGPKREPQSYTNIQQAIGVEPQEILFLSDIVQELDAAQSAGLQTCGLAREGGELEGHVTVDSFTGIEPEAF
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: Y1583_MYCTU
Sequence: MTAGAGGSPPTRRCPATEDRAPATVATPSSADPTASRAVSWWSVHEHVAPVLDAAGSWPMAGTPAWRQLDDADPRKWAAICDAARHWALRVETCQEAMAQASRDVSAAADWPGIAREIVRRRGVYIPRAGVA
What are the official names of this protein?
Uncharacterized protein Rv1583c.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv2656c.
Protein: PANB_ACAM1
Sequence: MAVTIHQLRTWKEQGRPISVLTAWDFPFATLLDQAGVDVLLVGDSLAMVALGYPTTLPLTLDEMLYHAQAVTRGVNHALVICDLPFLSYQESPQQALRSAGTLLQQAGVAAVKLEGGYPDMAKTVHYLVDRGIPVMGHVGLTPQSVHQFSGYRRQGTSDVEADRILQEAIALEAAGAFAIVLEHIPAPLATKITQTLTIPTIGIGAGPGCDGQVLVTADMLGLSAWQPPFAKAYTNLQESITGAVQQFCDDVRHHQFPQ
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTC6_ZYGRC
Sequence: MNGLLLILLVYITVWRPRPCQCIQERDIQRDVEDLPSVSYQVQYGIRSQRDLMANVPIDQVPMIGVNIFDAFLKNGRNNDSRALLSFMELMQHGVQSFTVDLEPRNSQWMLKKSNISFTRFLNVFQTYVNGSDNNLSANMLVLLLKISPGNESNSTGTGKNGSNLTRILDQSFGRQRIYTPDDLDYDREYGRTFSTFGANSVGWPILGSFLYDKKRRVILMEVTNHLVYQNTPYIFNGSSILHLDEGNATLGIPTTVDQIQNLSSISWKFLEASFTTTDIKQYVDIGYNPVITNEYSVGDFGDIYQLLNLTILWSWKPDQPKTIQSSDSAREHQLIAYNCAALHYTSANFSASWDVENCYAIHKGLCKHRFNDYIWVISKGHDNYFGFDSHSESKCPEDYYFSLPKTPLEQLAITQYLRNTSSEDALFWIDMNSVSVNDCWVTGGPDATCPYQRSVSKRNFVAMLTPVTVCSFVILCVVFYLNVLHVPIHNNRKSWRRIITEVSKWEVDGVPS
What is the function of this protein?
May be involved in telomere capping.
What are the official names of this protein?
Maintenance of telomere capping protein 6.
What is the protein family that this protein belongs to?
Belongs to the MTC6 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.