PharMolix/UniProtQA huggingface dataset:
Protein: NAGD_STAA3
Sequence: MKQYKAYLIDLDGTMYMGTDEIDGAKQFIDYLNVKGIPHLYVTNNSTKTPEQVTEKLREMHIDAKPEEVVTSALATADYISEQSPGASVYMLGGSGLNTALTEAGLVIKNDEHVDYVVIGLDEQVTYEKLAIATLGVRNGATFISTNPDVSIPKERGLLPGNGAITSVVSVSTGVSPQFIGKPEPIIMVKALEILGLDKSEVAMVGDLYDTDIMSGINVGMDTIHVQTGVSTLEDVQNKNVPPTYSFKDLNEAIAELEK
What is the function of this protein?
Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
What are the official names of this protein?
Acid sugar phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. NagD family.
Protein: Y773_METJA
Sequence: MERLPYEIVSTIFRKAILHYVLIRGTTYPQSLAENLNISKGLASSFLRLCSALNIMKRERAGHKVLYSFTSKGLAILKRLAPEIFDLSFSSVFEQLPKKKIATKYYPVDKIGFEISWKEDKLGGIVFSFFDSNGEHLGDVFRSNKGYWWCVICQSDTCKHIDYLKRLYKTLKNQD
What are the official names of this protein?
Uncharacterized protein MJ0773.
Protein: GLYA_SALPK
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMAKLAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEATIERVKAKVLDICARFPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_XYLFA
Sequence: MGANTFGKLLAVTTFGESHGPAIGCVIDGCPPGLELAAEEFAHDLQRRATGRSRHTSARREADEVEILSGVYEGRTTGTPIALLIRNTDQRSKDYATIARQFRPGHADYTYWQKYGIRDPRGGGRSSARETTMRVAAGVVAKKWLKQRYGVIVRGFLSQLGEIRPEGFAWDAVEDNPFFWPQAAQVPELEAYMDALRKSGNSVGARVDVVAEGVPPGWGEPIYGKLDGELAAALMSINAVKGVEIGAGFGSTVQKGTEHRDLMTPLGFLSNHAGGIIGGITTGQPIIVSIALKPTSSLRLPGETVDVDGHPVQVITKGRHDPCVGIRAPPIAEAMVALVLMDQALRHRAQCGDVGEMSPCILENVGFRNADD
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: 5HT7R_XENLA
Sequence: MLIQVQPSHLTDTNLSLHSAKPSSDHQNLLPSEFMTERPLNTTEQDLTALNHTEKPDCGKELLLYGDTEKIVIGVVLSIITLFTIAGNALVIISVCIVKKLRQPSNYLVVSLAAADLSVAVAVMPFVIITDLVGGEWLFGKVFCNVFIAMDVMCCTASIMTLCVISVDRYLGITRPLTYPARQNGKLMAKMVFIVWLLSASITLPPLFGWAKNVNVERVCLISQDFGYTVYSTAVAFYIPMTVMLVMYQRIFVAAKISAEKHKFVNIPRLYEQEGIYCLEDKLPPKKNSKKKKAVEEFASLSKLIRQDRKNISIFKREQKAARTLGIIVGAFTFCWLPFFLLSTARPFICGIMCSCMPLRLERTLLWLGYTNSLINPLIYAFFNRDLRTTFWNLLRCKYTNINRRLSAASMHEALKVTERHEGIL
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.  The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
What are the official names of this protein?
5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, Serotonin receptor 7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FTSK_BRUSU
Sequence: MRQGYSPSYPLRDERITEDRLRFANLVRRQVYILLGLGLLSLTAMAVGALATWNVADPSFSHATDNPVTNALGYPGAVFSDLAMQFFGLASVPALLPLAVWSLLLMIRGYIGRIARRSLAWVGAALLFAAIASCLAVPQSWPMPIGLGGVFGDMLLRIPGFFLGGFPQGAIASAIALVLAFPALWFCFFASGIIGRGAEAVNPAMLSANRSADDEFADEDADNEAGGGFHFIGALTHLVLMTTATIRRMTGLGRRRSREDDFDDMRMVRRSAETRNAPRREPGFGAPAADDEPPFDMDDMDDGAPLAGQEWHDAPPPRARKARVEQAAPSPKPGPRAQREAQPSFLKDNGIFEMPSLHFLAEPKLVQRDPALSKDALEQNARLLEGVLEDFGVRGEIINVKPGPVVTLYELEPAPGIKSSRVIGLADDIARSMSAIAARVAVIPGRNAIGIELPNPKREMVYLREMLASRDFEQSKAKLALALGKTINGEPVIADIAKMPHVLVAGTTGSGKSVAINTMILSLLYRMTPQECRLIMIDPKMLELSVYDGIPHLLTPVVTDPKKAVVALKWTVREMEDRYRKMSKVGVRNIDGFNQRVGLAQKKGEPIARTVQTGFDRNTGEAIYETEELDLEPMPYIVVIIDEMADLMMVAGKDIEGAVQRLAQMARAAGIHVIMATQRPSVDVITGTIKANFPTRISFQVTSKIDSRTILGEQGAEQLLGQGDMLFMAGGGRIQRVHGPFVGDDEVERIVQHLKLQGVPEYLDAITEDEDDDEGGSGPAGTGNLEDSDDPYDQAVAVVLRDKKASTSYIQRRLGIGYNRAASIIERMEDEGIVGPANHAGKREILVPTGDDDF
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination.  FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation.  FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: RHBG_PONPY
Sequence: MAGSPSRAAGRRLQLPLLSFLQGATAVLFAVFVRYNHKTDAALWHRGNHSNADNEFYFRYPSFQDVHAMVFVGFGFLMVFLQRYGFSSVGFTFLLAAFALQWSTLVQGFLHSFHGGHIHVGVESMINADFCAGAVLISFGAVLGKTGPAQLLLMALLEVVLFGINEFVLLHLLGVRDAGGSMTIHTFGAYFGLVLSQVLYRPQLEKSKHRQGLYHSDLFAMIGTIFLWIFWPSFNAALTSLGAGQHRTALNTYYSLAASTLGTFALSALVGEDGRLDMVHIQNAALAGRVVVGTSSEMMLTPFGALAAGFLAGTVSTLGYKFFTPILESKFKVQDTCGVHNLHGMPGVLGVLLGVLVAGLATHEAYGDGLESVFPLIAEGQRSATSQAMYQLFGLFVTLMFASVGGGLGGLLLKLPFLDSPPDSQCYEDQVHWQAPGATLSPLPTPAFQVPGEHEDKAQRPLRVEEADTQA
What is the function of this protein?
Ammonium transporter involved in the maintenance of acid-base homeostasis.  Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism.  May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (By similarity).  May act as a CO2 channel providing for renal acid secretion (By similarity).
What are the official names of this protein?
Ammonium transporter Rh type B, Rhesus blood group family type B glycoprotein, Rh family type B glycoprotein, Rh type B glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: RLP24_ASHGO
Sequence: MRIYSCHFCSSPVYPGHGIMFVRNDAKEFRFCRSKCHKAFKQRRNPRKLKWTKAFRKAAGKELAVDSTLTFAQRRNVPVRYNRELVETTLKAMTRIEEIRQKRERAFYKNRMKGNTEKDFLRDKKLVESNPELLKMREVELQRQAERAAAGVDEDAEMGDSDEEMEDASEEESEEEEQQQQKIVLKNKKRSAKKIAF
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  Ensures the docking of NOG1 to pre-60S particles.  Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles.
What are the official names of this protein?
Ribosome biogenesis protein RLP24.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: Y851_STAES
Sequence: MGEVKHLQINYKTDELFADFREFGNKNLYMIEELKGQMIDASSDSPFYGIFVGNKLVARMALLDKGEVEETYFPNSNDYILLWKLEVLDTYQRRGYAKQLLNFAKENKKPIKAIARNNSKEFFLKQGFKDVETKNPEGHDILIWNP
What are the official names of this protein?
Uncharacterized N-acetyltransferase SE_0851.
Protein: YDJC_VIBPA
Sequence: MKVIFNADDFGLTQGVNNGIVKSHQDGVVKSTTMMVGMDAEQNAIELAHQNPDLKIGVHLRFTAGAPLTEHPNLTNGRTHFVKYSELWNKQDFEAQAVYDEAKAQIDHFLSLGLTLSHLDSHHHAHTHPQILPIVQKLAKEHRVPLRGSGICHQPMTTSYFFTDEFYDQKVSLDGLMQHLLSLKENYDVVEVMCHPAYADQPLIMKSGYALQRELELQVLTSPILKEQLAQHGIAVTDYSALVSTSQVVGV
What is the function of this protein?
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
What are the official names of this protein?
Carbohydrate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family.
Protein: PAN2_PHANO
Sequence: MEADWNELVTAQLSPPGSHPPAVPISTFAFDTTQELLWTGNNQGRVTSLYGPSLERYTSYRGHATSDGPVKQFLFTDKGVLSISRQSVHYSHRRGLTQWHLTSPDFKDLKCMNFTSKGTREILIAGCQEQMFKVDVEKGIVVDTLPVDAQYTIMKRAGQYLCAATKTGGIHILDSNSLSVIKVFEGHTGSISDMDAKGDFLATCGWSPRQQYAYMLDPFTNVFSLKTLKQLAPVPFHTGAAFVRMHPRMSTTAIIASQNGQMQVIDLMNPDSANLRQLNLYDSYLAGFEMAPSGEAFALADSNSNVHLWGSPAKVHFPEYSNPTEFADHVIPPASMDWSLDTPLNTIGMPYYKETLLSGWPSHMVFEVGAPPPKIDGAILSNMTRTDMGFFAKNPRTKRRNQIEVTRQTDRSSDSLTPPKFLSEKSRASLSLSEANAKAVETMETLTDLHLDDVTRKDVPAMYGNVEIKYSKFGVDDFDFAYYNQTPFSGLETHITNSYANSLLQLFRFTPLIRNLALQHTASPCLFESCLLCELGFLIDMLEKAAGLNCQASNFLKTFSGLSNAVSLNLLEEFAPNVALTSMIQNLNRFLLDKISEEFRQMLPSHGGTSLMDQVLETQARASMRCAQCANETIRGGKNFVNELVYPAKHVMKNTRIPRPTFSQILKASVERQDQTRGWCTKCNRYQQMVQRKTIQSVPGVLMLNAAIQTHEAKLLWSIPNWLPHEIGIIVDQGQFYCFEGQDLKLHLQRGVFDIMVYELVGVVADINSGEHQKPHLVATINTGPSSREPDAEDKWHLFNDFLVRPIPREEALRFEPSWKLPSVLTFQTKSARNKIDDSWKENLDTSILYRWWSSNPTPPDDKFKLLQVSTEAPRPGYPVAIDAEFIRLQAEEIEMKADGTRQTIRPDRKGLARVSVCRGEGEHAGLPFIDDYIAVTEQVVDYLTEWSGISPGDLNRETSPHAPVSLKHAYKKLWLLLNLGCVFVGHSLANDFRTINIHVPRSQVVDTSNLFFLPDFKRKLNLKFLAWCVLKEQIQQDTHDSIEDATTALKLWRKYEEFVDAGVLEPMLNDIYATGSQVKFKAPGSGNRNSMPAGMTATGAGRDTPEPMTTPKKGGAFGGVGFRSPMRR
What is the function of this protein?
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex catalytic subunit PAN2, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. PAN2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_MICAN
Sequence: MLSPKRTKFRKQQRGRMRGLATGGNTINFGDFALQATEPCWITSRQIEAARRAMTRYIRRGGKIWIRVFPDKPVTQRAAETRMGSGKGSPEFWVAVVKPGFIMFEIAGVAEPVAREAMRLAAQKLPIKTKFITREEDFV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: EKI2_HUMAN
Sequence: MAVPPSAPQPRASFHLRRHTPCPQCSWGMEEKAAASASCREPPGPPRAAAVAYFGISVDPDDILPGALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVEEDMQDCVLVRVYGERTELLVDRENEVRNFQLLRAHSCAPKLYCTFQNGLCYEYMQGVALEPEHIREPRLFRLIALEMAKIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSADVPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQASALEMPK
What is the function of this protein?
Highly specific for ethanolamine phosphorylation.  Does not have choline kinase activity (By similarity).
What are the official names of this protein?
Ethanolamine kinase 2, EKI 2, Ethanolamine kinase-like protein.
What is the protein family that this protein belongs to?
Belongs to the choline/ethanolamine kinase family.
Protein: RS13_BURPS
Sequence: MARIAGVNIPNHQHTEIGLTAIFGIGRTRARSICVASGVAFSKKVKDLTDADLEKLREEVGKFVVEGDLRREVTMNIKRLMDLGCYRGVRHRKGLPLRGQRTRTNARTRKGPRRAAQALKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RPO3_PYRHO
Sequence: MVKIKILKKTEDSITFILEGVSVAFANALRRTILGEVPTFAVDEVEFYENDSALFDEIIAHRLAMIPLKTPTDRFELDALELDDYTVTLSLEAEGPGIVYSGDLKSDDPDVKPVTPDIPIVKLAKGQRLVFNAYAKLGRGKDHAKWQPGFTYYKYFTRVHISKKINGWEKLAKLAKKRGLPTKENEEEVIVETIKPFYIPKEFEEYEGKEIWEEIVPDTYVFVVETNGELPVEEIVKIALRILMRKADRFINELQRLAG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo3, DNA-directed RNA polymerase subunit D.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_FUSNN
Sequence: MYLTDPIADMLTRVRNANAVMHEKVDIPHSKMKERIAEILKEQGYISNFKIVTDEGNKKNIRVYLKYAGKERVIKGLKRISKPGRRVYSSVDDMPRVLSGLGIAIVSTSKGIVTDKVARAEKVGGEVLAFVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PFDB_THEAC
Sequence: MVEPNISAYLQNQLRQAQELEENIEKLATQRYQLDLSLKEMQKTLDELNKLDDNTPIYRTVGSILYRVQDKKKLVDELDEQIELTKIRLSTLEKQQKSLEEKYKELQNAIRDRYNQENKKGATS
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YSF3_YEAST
Sequence: MAEKQRQLKLQKIYKQKYIGLGDESTTREQWQRNVRNDTLNTLQGHSASLEYVSLSRGDLSIRDTRIHLLKSMSPGYKAYLREER
What is the function of this protein?
Involved in pre-mRNA splicing.  Required for the SF3b integrity and prespliceosome assembly.
What are the official names of this protein?
RDS3 complex subunit 10, Splicing factor 3b subunit.
What are the subcellular locations of this protein?
Nucleus.
Protein: ADRG_PENRW
Sequence: MTRRNEKEEVPPQGKILDLFHPGIAPYAELMRIHRLLGFYLNTSPYLVGVAFSASISSTKIPIAVLLHRAMLLSIWSIFLRSAGCVWDDLIDMDLDSQISRTKSRPLPRGAVSPSNALLLTVALFACGGTVLIFLPWACTVDCLIVTFFALSYPFGKRFTDYPQITLMNIGWAVPMAMHSLGLDPLSQMTPTVCMFLFIGSVIIMIDVIYSRQDTEEDLKVGVKSMAVRFRDSIQLLSYSLLCASTGFLAMAGVLTGLGLPFFVLSVGGHFCGFWVLLRATQVGKSSGVESYAKYNMPKQAFRPRPETSCATWLLSTSRNEMGRA
What is the function of this protein?
Prenytransferase; part of the gene cluster that mediates the biosynthesis of andrastins, meroterpenoid compounds that exhibit inhibitory activity against ras farnesyltransferase, suggesting that they could be promising leads for antitumor agents (Ref. 2).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase adrD via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Ref. 2).  DMAO is then converted to farnesyl-DMAO by the prenyltransferase adrG (Ref. 2).  The methyltransferase adrK catalyzes the methylation of the carboxyl group of farnesyl-DMAO to farnesyl-DMAO methyl ester which is further converted to epoxyfarnesyl-DMAO methyl ester by the FAD-dependent monooxygenase adrH (Ref. 2).  The terpene cyclase adrI then catalyzes the carbon skeletal rearrangement to generate the andrastin E, the first compound in the pathway having the andrastin scaffold, with the tetracyclic ring system (Ref. 2).  The post-cyclization tailoring enzymes adrF, adrE, adrJ, and adrA, are involved in the conversion of andrastin E into andrastin A.  The short chain dehydrogenase adrF is responsible for the oxidation of the C-3 a hydroxyl group of andrastin E to yield the corresponding ketone, andrastin D.  The ketoreductase adrE stereoselectively reduces the carbonyl moiety to reverse the stereochemistry of the C-3 position to yield andrastin F.  The acetyltransferase adrJ is the acetyltransferase that attaches the acetyl group to the C-3 hydroxyl group of andrastin F to yield andrastin C.  Finally, the cytochrome P450 monooxygenase adrA catalyzes two sequential oxidation reactions of the C-23 methyl group, to generate the corresponding alcohol andrastin B, and aldehyde andrastin A (Ref. 2).
What are the official names of this protein?
Prenytransferase adrG, Andrastin A biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: POTA_STRPF
Sequence: MTKPIITFNNVSKTFEDSGTQVLKNINFDLEEGKFYTLLGASGSGKSTILNIMAGLLDASSGDIYLDGERINDLPINKRDIHTVFQNYALFPHMTVFENVAFALKLKKVDKKEIAKRVKETLKMVQLEGYENRSIQKLSGGQRQRVAIARAIINQPRVVLLDEPLSALDLKLRTEMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNEGEIVQSGTPVDIYDEPINHFVANFIGESNIINGTMIEDYLVSFNGKEFESVDGGMRPNEPVEVVIRPEDLQITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMIHSTRKAIEGEVIGLDFTPEDLHIMRLNETEEEFDARIEEYVEMDEPEDGLINAIEEERNEENL
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DNAJ_SHEWM
Sequence: MSKRDYYEVLSVGRDASEREIKKAYKRLAMKFHPDRNPGDKAAETSFKEVKEAYEILTDSDKKAAYDQFGHAGVDPNRGGGGFGGNADFGDVFGDVFGDIFGGGRRGGGQRQAARGSDLRYNLELSLEEAVKGLTKELRIPTLAHCDTCDGSGAKKGTSPTTCGTCHGQGQVQMRQGFFAVQQACPTCHGRGKIIKDPCNSCHGEGRVEKSKTLSVKIPAGVDNGDRIRLSGEGEAGEFGAPPGDLYVQVSVREHAIFVRDGNNLYCEVPISFGKAALGGEIEVPTLDGKVNLKIPAETQTGRMFRMRGKGVKSVRSHAVGDLLCKVVMETPVKLNERQKELLREFDETLAGSSSKKHSPKAEGFFDGVKKFFQDLNS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYC1_CYPCA
Sequence: MPVSASLAYKNYDYDYDSIQPYFYFDNDDEDFYHHQQGQTQPPAPSEDIWKKFELLPTPPLSPSRRQSLSTAEQLEMVSEFLGDDVVNQSFICDADYSQSFIKSIIIQDCMWSGFSAAAKLEKVVSERLASLHAARKELMSDSSSNRLNASYLQDVSTSASECIDPSVVFPYPLPESGKSSKVAPSEPMPVLDTPPNSSSSSGSDSEEEEEEEEEEEEEEEEEEIDVVTVEKRQKKNETAVSDSRYPSPLVLKRCHVSTHQHNYAAHPSTRHDQPAVKRLRLEASSNSNSRHVKQRKCTSPRTSDSEDNDKRRTHNVLERQRRNELKLSFFALRDEIPDVANNEKAAKVVILKKATECIHSMQLDEQRLLSIKEQLRRKSEQLKHRLQLLRSSH
What is the function of this protein?
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.  Activates the transcription of growth-related genes.
What are the official names of this protein?
Transcriptional regulator Myc-1, c-Myc-1, c-Myc I.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPG_SALEP
Sequence: MAGAKEIRSKIASVQNTQKITKAMEMVAASKMRKSQDRMAASRPYAETMRKVIGHLANGNLEYKHPYLEERDVKRVGYLVVSTDRGLCGGLNINLFKKLLADMKAWSDKGVQCELAMIGSKGVSFFNSVGGNVVAQVTGMGDNPSLSELIGPVKVMLQAYDEGRLDKLYIVSNKFINTMSQVPTITQLLPLPASEDDDLKRKAWDYLYEPDPKALLDTLLRRYVESQVYQGVVENLASEQAARMVAMKAATDNGGSLIKELQLVYNKARQASITQELTEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS10_IDILO
Sequence: MANQRIRIRLKAFDHRLIDQSTAEIVETAKRTGAQVRGPIPLPTRKERFTVLISPHVNKDARDQYEIRTHKRLIDIMDPTDKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: AER_PSEAE
Sequence: MRNNQPITQHERVYPAEQRLITTTNLKGIITYCNEAFIDISGFSREELMSAPHNLIRHPDVPPAVFAHMWTTLKAGRPWMGIVKNRCKNGDHYWVSAYVTPIYDQGAVVGYESVRVKPTAEQIQRAEALYRRLGAGKPAIPRRDRWLPVLLDWLPFILISQIGFLIGIWLNSWWGFILAGLLAVPLGLAGLRWQKRGLKRLMRLAEQTTSDPLIAQMYTDSRGDQARLEMAILSQDARLKTCLTRLQDTAEYLTEQARQADTLAHHSSAGLEQQRAETEQVATAVNEMAATTQEVANNVQLTADATQKANELTSRGRDIAAETRNAIQRLSESVGETGAAVSRLAQDSNEIGGVVDVIKGIADQTNLLALNAAIEAARAGDQGRGFAVVADEVRSLAQRTAASTEQIHHLIAKLQNTANDAVHTMESGLQQAEAGVQRVLEADSALVGISEAVSNITEMTTQIAAAAEEQSAVAEEINRNISTIAALAEQTSDEALRTAKLSEELTTTAQSQYSLVERFNR
What is the function of this protein?
Chemotactic transducer for aerotaxis.
What are the official names of this protein?
Methyl-accepting chemotaxis protein Aer, Aerotaxis receptor Aer.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.