PharMolix/UniProtQA huggingface dataset:
Protein: GREA_RHILO
Sequence: MNKVPMTGEGFASLKEELRWRQQEERPRIIEAISEARSHGDLSENAEYHAAKEAQSLNEGRVNELEDLIARAEVIDVTKLSGDKVKFGATVVLVDEDTEEKKTYQIVGDQEADVKSGRISISSPIARALIGKEVGDAIEVNAPGGARGYEIVQVQFI
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: MINE_HAMD5
Sequence: MGFFDFFSPDKKNSAANIAKDRLQIIVRERRCCDRDPLYLSDMKRDILAVICKYVQLDPNALHVQFEQKEDDVSVLELNVILPEVSSTGDCSKP
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: PSTB_HALH5
Sequence: MALTVKEKKNVEVVVPQPRQKHVIQGEPTVAYETRDLNLWYGKDHALKNINLSIYEKEVTAIIGPSGCGKSTYLKTLNRMVELVPSVRISGNISYRGRNILDKSFQVEELRTRVGMVFQKPNPFPKSIFDNVAYGPRIHGIRNKKILSEIVERSLRGAAIWDEVKDRLHENAYGLSGGQQQRLCIARCLAIEPDVILMDEPTSALDPKSTLKIEELIQELKKEYSIIIVTHNMQQAARISDKTAFFLNGEVVEYDSTDIIFSNPSDKRTEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
Protein: SE1L1_HUMAN
Sequence: MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREASIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDMFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPAPRPPGPRPAPPQQEGPPEQQPPQ
What is the function of this protein?
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207).  Enhances SYVN1 stability.  Plays a role in LPL maturation and secretion.  Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells.  May play a role in Notch signaling.
What are the official names of this protein?
Protein sel-1 homolog 1, Suppressor of lin-12-like protein 1, Sel-1L.
What is the protein family that this protein belongs to?
Belongs to the sel-1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: LPXB_SHESW
Sequence: MSKKSQLVFAMVAGELSGDILGAGLMAALQKSHPDARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLKVRASLIKDITALKPDCFIGIDAPDFNIGLELKLKARGIKTVHYVSPSVWAWRPKRIFKIAKATHMVLSLLPFEKAFYDKHQVPCTFVGHTLADDIPLRSDKAAARQLLELDADAEYLAILPGSRGGELKQLAEPFVKAALLIKENFPDIRFVTPLVNQKRRDQFEQALKDHAPDLEIHMVEGKSREVMTAADGILLASGTATLEAMLVKRPMVVAYRVSPLTYRIAKSMMQVNRFSLPNLLAGKDVVPELIQDDCTPEKIAAAVTVELNRDFAPLNAEFERLHQMLRCDASQKAADAVMRLVETKEG
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: VATL_ORYSJ
Sequence: MSSVFSGDETAPFFGFLGAASALIFSCMGAAYGTAKSGVGVASMGVMRPELVMKSIVPVVMAGVLGIYGLIIAVIISTGINPKAKPYYLFDGYAHLSSGLACGLAGLAAGMAIGIVGDAGVRANAQQPKLFVGMILILIFAEALALYGLIVGIILSSRAGQSRAD
What is the function of this protein?
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase.  V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase 16 kDa proteolipid subunit, V-ATPase 16 kDa proteolipid subunit, Vacuolar proton pump 16 kDa proteolipid subunit.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase proteolipid subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: CT53_CONAE
Sequence: MLCLPVFIILLLLASPAASNPLEKRIQNDLIRAALEDADMENDPRSIIDSVKTFCCSTFNLGICCSKK
What are the official names of this protein?
Conotoxin Ar5.3, Conotoxin ArMLCL-0111, Conotoxin ArMLCL-0212, Conotoxin ArMLCL-D01.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLB1L_MOUSE
Sequence: MPPDLPSLLLRLVVLLLLSQAEARSFVVDREHDRFLLDGVPFRYVSGSLHYFRVPPVLWADRLLKMQLSGLNAVQFYVPWNYHEPEPGIYNFNGSRDLIAFLNEAAKVNLLVILRPGPYICAEWEMGGLPSWLLRNPNIHLRTSDPAFLEAVDSWFKVLLPKIYPFLYHNGGNIISIQVENEYGSYKACDFKYMRHLAGLFRALLGDKILLFTTDGPHGLRCGSLQGLYTTIDFGPADNVTRIFSLLREYEPHGPLVNSEYYTGWLDYWGQNHSTRSSPAVAQGLEKMLKLGASVNMYMFHGGTNFGYWNGADEKGRFLPITTSYDYDAPISEAGDPTPKLFAIRNVISKFQEIPLGPLPPPSPKMKFGPLTMSLDGNLLSFLDFLCPQGPIHSVLPLTFEAVKLDHGFMLYRTYLTSPVLEPTPFWVPNNGIHDRAYVMVDGVLKGVLERSLKQELYLTGTVGTRLDILLENMGRLSFGSNHSDFKGLLEAPLLGQTILTEWMMFPLKVDKLVKWWFPLQLMKRALPQASSVPAFYSAKFPVFGLLGDTFLYLPGWTKGQVWINGFNLGRYWTMRGPQQTLYVPRLLLFGRSINKITLLELENVPHNPQVQFLDKPILNSTLHWGYNFLLSETQGSFEPMELSGH
What is the function of this protein?
Probable glycosyl hydrolase.
What are the official names of this protein?
Beta-galactosidase-1-like protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL34_LEVBA
Sequence: MKRTYQPKKRHRSRVHGFRKRMSTSNGRQVLARRRQKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RL7A_HYPBU
Sequence: MSKPFYVRFEVPPELAEKAYQALEIARKTGKIKKGTNETTKCVERGLAKLVLIAEDVDPPEIVAHLPLLCEEKKIPYVYVPSKKRLGEAAGIEVAAASACIIDPGEAKNLVEEIVKAVNELKTKAAQ
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_BORRA
Sequence: MEVKIEESWKEMLKSEFCKGYFKRLVSFIKNEYKTKKDKIFPPPRLIFNAFDTLPFKDIKVVILGQDPYHGKGQANGLAFSVNSDIKIPPSLQNIFKEIERSLKIKTIPNGDLTRWAEQGTFLLNSILTVEEGRPSSHKDIGWKIFTNEVIKIISKNLNNVVFMLWGNFAKGKKKLIDTSKHLILETSHPSPYSAHNGFLGSNHFSKTLRYLQEHNKTTINFQ
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1458_OCEIH
Sequence: MENVKVENLLINYKTLEKFKRFREYGNQELTMMEDLENNIIENDSKSPFYGIYFGNNLIARMSLYEVSKQYDYYFEPSQDYLTLWKLEVLPDYQNKGYGEVLVNFAKSFELPIKTNPRINSHGFWEKMGFIKAHYEMERDLGENPLIWLPEGVKEKDMKS
What are the official names of this protein?
Uncharacterized N-acetyltransferase OB1458.
Protein: PO3F3_PIG
Sequence: FTQRRMKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNNLQ
What is the function of this protein?
Transcription factor that acts synergistically with SOX11 and SOX4.  Plays a role in neuronal development.  Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).
What are the official names of this protein?
POU domain, class 3, transcription factor 3, Brain-specific homeobox/POU domain protein 1, Brain-1, Brn-1.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MEP1_ARTGP
Sequence: MHGLLLAAGLLSLPLRVLAHPQPSTSLTSQGVDLNAYRMADRSSYMSSDEMKLEQPSISSLSGGNYVETATEVVKRMMPGVTFRMVDDHYVGESGISHVYFRQTMHGMDIDNSDFNVNIGKDGKVLSFGNSFYTNPTPDKAPVEKRDFSDPMKALHGARKALNLPINADKATIKSMNEHEVMFMGTSGALSDPQGKLCYMAKEDGTLALTWRVETDMGDNWLLSYVDAKDTDKVHNVVDYVSHATYQVYPWPVPDPTEGKRAVLQNPWNLKASPFTWISDGKNNYSTTRGNNAIAQANFDGGSDYLNNYRPNNKNLKFEYPYAPNMSPPKSYIDASVTQLFYSANMVHDLYYMLGFTEKAGNFQVNNRNQGGKGGDFVILNAQDGSGTNNANFATPPDGQPGRMRVYIWTKAKPARDSSFEAGTVIHEYTHGLSNRLCGGPANSACLNGMESGGMGEGWGDFFATAIRLKPNDNRNANYVHGEWVNNSPRGNRMFPYSTSLQTNPLVYTSCNKYNEVHAIGTVWCSILYEVLWNLIDKHGKNDGPTPVFENGVPKDGKYLAMKLVLDGMAIQPCKPTFVQARNAILDADMNLTKGANKCELWKAFAKRGLGTGAKYDPKNRTGSKAVPKECQ
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates and probably acts as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 1, Elastinolytic metalloproteinase MEP1, Fungalysin MEP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SKI_CHICK
Sequence: METVSRSSFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEMYKKDNGKDPAEPVLHLPPIQPPPVMPGPFFMPSDRSTERCETILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGTYPPHCKKEFSSTIELELTEKSFKVYHECFGKCKGLLVPELYSNPSAACIQCLDCRLMYPPHKFVVHSHKSLENRTCHWGFDSANWRSYILLSQDYTGKEEKARLGQLLDEMKEKFDYNNKYKRKAPRNRESPRVQLRRTKMFKTMLWDPAGGSAVLQRQPDGNEVPSDPPASKKTKIDDSASQSPASTEKEKQSSWLRSLSSSSNKSIGCVHPRQRLSAFRPWSPAVSANEKELSTHLPALIRDSSFYSYKSFENAVAPNVALAPPAQQKVVSNPPCATVVSRSSEPPSSAAQPRKRKHAAETPAVPEPVATVTAPEEDKESEAEIEVETREEFTSSLSSLSSPSFTSSSSAKDMSSPGMQAPVPVNSSYEVAAHSDSHSSGLEAELEHLRQALDSGLDTKEAKEKFLHEVVKMRVKQEEKLNAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRIRLKRELEQARQIRVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLMHEREAREHLEKVVKELQEQLWPKSSSQSSSENTTSNMEN
What is the function of this protein?
May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage.  May function in TGF-beta signaling (By similarity).
What are the official names of this protein?
Ski oncogene, Proto-oncogene c-Ski.
What is the protein family that this protein belongs to?
Belongs to the SKI family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL2_STRPD
Sequence: MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVSLKSKAGRNNNGRITVRHQGGGHKRHYRLIDFKRNKDGVEAVVKTIEYDPNRTANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPDADIKVGNALPLANIPVGTVVHNIELKPGKGGELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATIGTVGNEQQSLVNIGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CB3_ARATH
Sequence: MASTFTSSSSVLTPTTFLGQTKASSFNPLRDVVSLGSPKYTMGNDLWYGPDRVKYLGPFSVQTPSYLTGEFPGDYGWDTAGLSADPEAFAKNRALEVIHGRWAMLGAFGCITPEVLQKWVRVDFKEPVWFKAGSQIFSEGGLDYLGNPNLVHAQSILAVLGFQVILMGLVEGFRINGLDGVGEGNDLYPGGQYFDPLGLADDPVTFAELKVKEIKNGRLAMFSMFGFFVQAIVTGKGPLENLLDHLDNPVANNAWAFATKFAPGA
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated (PubMed:26562806).  Modulates the rate of photosystem II (PSII) state transitions and influences PSII macrostructure (PubMed:19880802).  Involved in PSII excitation energy transfer and charge separation during photosynthesis in thylakoids (PubMed:26562806).
What are the official names of this protein?
Chlorophyll a-b binding protein 3, chloroplastic, Light-harvesting chlorophyll B-binding protein 3, LHCB3*1, Lhcb3.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ARCH_METJA
Sequence: MFNYFETTADLGVEAKGKSLEEAFKEGAKGLYNIMVDIDKVDKKEKIEFEITGEDLEELLYNFLNELLFYTDVENLVFNDFDVKIEKNDNGYRLKCTAYGEKINKEKHNIKEEVKAVTYHKMEIKQEEDGWKIRYIVDL
What is the function of this protein?
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB.  Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation.  Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
What are the official names of this protein?
Protein archease.
What is the protein family that this protein belongs to?
Belongs to the archease family.
Protein: HCT1_ACTRA
Sequence: MVCIKSSCVVKPSEPTPNVKLFLPESDQVKPWTHAPVFFVYQPEVDNSVSTSLENLKFSLSRALVPYYPLAGRLNGIGGGRFELHCNTMGAVIIEAESDARLEDFGDFRPTSETTKLAPYVDYAKDVSELPLLLVQLTRFKCGGIGIGIAMSHIVSDGKGAFGFITTWAKINRGEKGIIEPFHDRTAFYKGDPTAKPRCDHVELKGYPVLLGNKSAKEERAKETTTRMLNLSKNQVDKLKEKSNLGKPKDYVGREYSRFEAMSGHIWRCASKARRHENEQLTSLRITIDCRNRLRPPLPPRYSGNATMVTTSIAESGELLSNPLGLGFVCSVIRKCIDKVDDDYIKSATDFLISQDDLTPYRSGFHNVGSTEGVFLGNPNLAITSWVGLPINDVDFGWGKPIYMGPTALGYDGKLLIIPGKDDGSVIVPIRLQVAHIDDFEKFFYEDI
What is the function of this protein?
Catalyzes the formation of cimicifugic acids.  Uses hydroxycinnamoyl-CoA thioesters as hydroxycinnamoyl donor substrates.  Has a strict specificity for piscidic acid as an acceptor substrate as none of the various other acceptors tested including 4-hydroxyphenyllactic acid, malate, spermidine or tetrahydroxyhexanedioic acid are substrates.  Donor substrates include 4-coumaroyl-CoA, caffeoyl-CoA, sinapoyl-CoA and feruloyl-CoA.  No activity with cinnamoyl-CoA, isoferuloyl-CoA, 3,4-dimethoxycinnamoyl-CoA or 3,4-dihydroxybenzoyl-CoA as donors.  In the reverse reaction with fukinolic acid and CoA as substrates, a formation of fukiic acid is evident.  Hence, fukiic acid may also serve as an acceptor substrate.  Involved in the biosynthesis of cimicifugic and possibly fukinolic acids.
What are the official names of this protein?
Hydroxycinnamoyl-CoA:piscidic acid hydroxycinnamoyltransferase, ArHCT1, ArHPT1, BAHD acyltransferase/hydroxycinnamoyltransferase, BAHD-type hydroxycinnamoyltransferase, Cimicifugic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: NU1M_VOMUR
Sequence: MFIINLLLYIVPILLAVAFLTLVERKVLGYMQFRKGPNIVGPYGLLQPIADAVKLFTKEPLRPLTSSISMFIIAPILALTIALTIWTPLPMPHTLIDLNLGLLFILALSGLSVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSIMLINGSFTLKNLIITQENMELIVTTWPLAMMWYVSTLAETNRAPFDLTEGESELVSGFNVEYAAGPFAMFFLAEYANIMVMNAMTTILFLGSSLNHNFTHLNTLSFMTKTLALTLLFLWIRASYPRFRYDQLMHLLWKSFLPITLALCLWFISIPVALSCIPPQL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRX1_GAHVM
Sequence: MKPLLRSHETQYYSLYPDTLNGLHNVFRTIGNSVQSDTVRRLNLGYLDGDNRRGNLAGGLELLRDATTPNASRMNITRPLDTSTSGATAMIMQSLRTDVAENITLLTGDSRATISRQVTLTDFCFPDAEMPGLIILSIRHPLDINSEALYATPAGRDPRVMETVWYELSELAAVSVNRVNGSGVRPSLVSLSFLIAARASDYADKCGAEALRAHVISNYGRRRMEEKLDRFGICLITMLRCRVFPHRHFQLLGGLISWISQREIASITAVVRGPQESIKTEQTAMPRSSVYVPACAYIDFDKDIRVIHEERSSSSLYLVFVYTQKFGRETVRIYVMRSRLGEWAFREGLGYMYSGVRSNNAITGVDGLIVPHGANVNMEFPLTKTLDLRNRDRRLGIAARSRDLNKADWKVDLRGRPTKESCMYAAYCRLGHLDESSVPVKKFERCGSLDIPVIWIPGVIWNIGTWIECY
What is the function of this protein?
Structural component of the T=16 icosahedral capsid.  The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes.  These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2.  Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.
What are the official names of this protein?
Triplex capsid protein 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRX1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: MARHA_RAT
Sequence: MLHEARDRQKFVSDVQYLRDMQHKVDSEYQACLKRQEHKKEPNEKKQEQLWGKDTSDRSRFSSGSSCKQSSGEEDSLSEARLATKAPTAKCEPKLPAIDQTSVKQKHKGTMTLKKPEKVSPSKPSAVAQATKILSRKRRPNLGRLTVSPEMHSPRLSGERSRQKAQLSTKTSGLLGADPVVQQDSLLSANEMKLKRPAREKRNLAPSSQLVRVAGKAPLERQKKGDPSARPQNEPHTALSQTFQPMSGSQVLTESSVPPFLPATVVGPRRAPFRFHDEDFYSALSLNNEQENYDTEEETRTEEELLLAGMRSPPSYKRSRFLGTSAAQNRNVEENAENLRGNSLRRSEPNPGSPRKTSVTEPTTKQSSPGQRMLQDTRLPRELAKDNPSGDQDEKTPVPGDAKSDGVTQVSAEDVSNNCAVEDRSAVHNCERDWQRYLSGSRNSFDCLLSGRPTAPRASVNPSYNAHGSLFHSAVIDDIPASLSVSSILVPSAELEENLRFNVRRPLSPIRNRNPSAASESHSEDTQGEEERASTSQAQESPLLSDLPNPQSSMALGDSPSSPTRRHLQGHFYMPGSLQENIPFTFFAVSDFASQNDNGTSVRVSGVMDEKATEIKADPEKLRKLQESLLEEDSEEEGDLCRICQIAGGSPANPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLSTVKTCEMCKQGLLVDLDDFNMTEFYHKHQQSRAQSELMNSGLYLVLLLHLYEQRFAELMTLNYRRASRERMSRNYPQPRPEESESSESGDGNESNVYPGRVI
What is the function of this protein?
E3 ubiquitin-protein ligase (Probable).  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase MARCHF10, Membrane-associated RING finger protein 10, Membrane-associated RING-CH protein X, MARCH-X, RING finger protein 190, RING-type E3 ubiquitin transferase MARCHF10.
Protein: RUVB_COXB1
Sequence: MDEKIETRLIGATVQSNEPDLERSIRPKRLSDYIGQAAVREQMDIFIRAATNRREALDHVLIFGPPGLGKTTLAHIIAHEMQAGLKQTSGPVLEKAGDLAALLTNLEPHDVLFIDEIHRLNPAIEEVLYPALEDFQLDIIIGEGPSARSIKLDLPPFTLVGATTRAGLLTSPLRDRFGIVQRLEFYRIPDLIHIVKRAAHILNVVIDENGAGEIARRSRGTPRIANRLLRRVRDFAEVRANGMINESIAKEALDLLNVDIRGLDVMDRKLLETIIKKFQGGPVGIESLAAAISEERGTIEDVIEPYLIQEGFILRTPRGRIATELTYQHFKLPLPTQSTLQENFDLLGKVE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MURC_ALISL
Sequence: MTTEQKLQLAEIRTMIPEMRRVECIHFVGIGGAGMSGIAEVLLNEGYHISGSDVAENSVTVRLAEKGADIFFGHHASNVEKASVVVVSTAIDQANPEIVAAKENRIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTALTTQIYSEAGLDPTFVNGGLVKNAGTNARLGSSRFLIAEADESDASFLHLQPMVSIVTNIEADHMDTYGGDFEVLKQTFIDFLHNLPFYGQAVMCIDDDVVRELLPRVSRQVITYGFSDDADVRLINYRQEGQKSFFTVQRKDRTDLDIVLNIPGKHNALNATAAIAVATEEDVEDSAILSALLNFEGAGRRFDQLGEFETGNGHAMLVDDYGHHPTEVDVTIKAARAGWEDKRLVMIFQPHRYSRTRDLYDDFANVLDNVDVLIMLDVYSAGEKPIAGADGRALCRTIRARGKLDPIFVPTIDALPSVLANIIQNNDLVLTQGAGDVGKLAKQLASLELNIQAMKELG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMYR_DROJA
Sequence: MIKFALALTLCLAGASLSLAQHNPQWWGNRNTIVHLFEWKWSDIAEECETFLAPRGFAGVQVSPVNENIISAGRPWWERYQPISYKLTTRSGNEEEFADMVRRCNDVGIRIYVDVLLNHMSGDFDGVAVGTAGTEAEPSKKSFPGVPYTAQDFHPSCEITDWNNRFQVQECELVGLKDLNQHSDYVRSKLIEFLDHLIELGVAGFRVDAAKHMAAEDLEYIYGSLSNLNIEHGFPHNARPFIFQEVIDHGHETVSREEYNQLGAVTEFRFSEEIGKAFRGNNALKWLQSWGTDWGFLNSEQALTFVDNHDNQRDQGSVLNYKSPKQYKMATAFHLAYPYGISRVMSSFAFDDHDTPPPQDAQENIISPEFDEDGACVNGWICEHRWRQIYAMVGFKNAVRDTELTGWWDNGDNQISFCRGNKGFLAVNNNLYDLSQELNTCLPAGEYCDVISGSLIDGACTGKSVTVNEYGYGYIHIGSDDFDGVLALHVNAKV
What are the official names of this protein?
Alpha-amylase-related protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNFA_AERHH
Sequence: MTEYLLLLVGTVLINNFVLVKFLGLCPFMGVSGKLETAIGMGLATTFVMTLASACSYLMEHYILIPLNIAYLRTLAFILVIAVVVQFTEMVIRKSSPTLYRLLGIFLPLITTNCAVLGVALLSINEHHNFIQSIIYGFGAATGFSLVLILFAAMRERLVAADVPTPFRGVSIAMITAGLMSLAFMGFTGLIKI
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.