PharMolix/UniProtQA huggingface dataset:
Protein: GDF8_ANTAM
Sequence: MQKLQIYVYIYLSMLIVAGPVDLNENSEQKENGEKEGLCNACLWRQNTKSSRLEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETVITMPTESDLLTQVEGKPKCCFFQFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGAGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPEPGEDGLNPFLEVKVADTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: QPCT_CROAT
Sequence: YPGSPGSYAVRLIFFDGEEAFVRWSPSDSLYGSRMASTPHPPGARHPVEDDHIPFLRGVPILHLIPSPFPR
What is the function of this protein?
Responsible for the biosynthesis of pyroglutamyl peptides.  Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue.  Also catalyzes N-terminal pyroglutamate formation (By similarity).
What are the official names of this protein?
Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, QC.
What is the protein family that this protein belongs to?
Belongs to the glutaminyl-peptide cyclotransferase family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y5768_DICDI
Sequence: MNPSIKYTIEINKYPISQSLNTNQFVMSASFISSETNDDICCLSKEFGNTTSSGGGGGGGGCGGGGCGGGGGGGGGGGGGGGVNNHSVYGRFIKRAIIDSKVQSIENILLDSTMKPISNLHIQLKVLLVSQFHNIQIVLLLIQTFQSLLIKVILKFVQIIHLLLKVNDRWYRHW
What are the official names of this protein?
Putative uncharacterized protein DDB_G0287183.
Protein: PANC_YERP3
Sequence: MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPLQFERPDDLAHYPRTLQEDCEKLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIRKMVADMGYDINIVGVPTVRAKDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEDAAAQLLRAGFTPDELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCMS_RHYMA
Sequence: QDVDHVFLRF
What is the function of this protein?
Inhibits the spontaneous contractions of cockroach protodeum (hindgut).
What are the official names of this protein?
Leucomyosuppressin, LeM-MS, LMS.
What are the subcellular locations of this protein?
Secreted.
Protein: TRUB_ECOL5
Sequence: MSRPRRRGRDINGVLLLDKPQGMSSNDALQKVKRIYNANRAGHTGALDPLATGMLPICLGEATKFSQYLLDSDKRYRVIARLGQRTDTSDADGQIVEERPVTFSAEQLAAALDTFRGDIEQIPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRHEGNELELEIHCSKGTYIRTIIDDLGEKLGCGAHVIYLRRLAVSKYPVERMVTLEHLRELVEQAEQQDIPAAELLDPLLMPMDSPASDYPVVNLPLTSSVYFKNGNPVRTSGAPLEGLVRVTEGENGKFIGMGEIDDEGRVAPRRLVVEYPA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: Y5989_PSEF5
Sequence: MRVWIDADACPKAAKDQVVRFALKRQFEVVLVAGQAQIKPAFACVRLIVVPSGPDAADDYLVEHAVPGELVICSDVPLADRLVKKGLAALDPRGKEFDAQNMGERLAVRNLFTDLREQGQVSGGQAPYGDREKQAFANALDRILTRLARQA
What are the official names of this protein?
UPF0178 protein PFL_5989.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: CRCB_PROA2
Sequence: MQERFSAVLLVGAGGFAGASARYLIAVALSSFATGFPMATMLVNVLGCFLIGMISELSLTTSLLPSELRLLLATGFCGGFTTFSSYMYEISALLKDGELFYASLYLIGSLVGGMVFLYLGMALARVWS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GABT_ECOLI
Sequence: MNSNKELMQRRSQAIPRGVGQIHPIFADRAENCRVWDVEGREYLDFAGGIAVLNTGHLHPKVVAAVEAQLKKLSHTCFQVLAYEPYLELCEIMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAATKRSGTIAFSGAYHGRTHYTLALTGKVNPYSAGMGLMPGHVYRALYPCPLHGISEDDAIASIHRIFKNDAAPEDIAAIVIEPVQGEGGFYASSPAFMQRLRALCDEHGIMLIADEVQSGAGRTGTLFAMEQMGVAPDLTTFAKSIAGGFPLAGVTGRAEVMDAVAPGGLGGTYAGNPIACVAALEVLKVFEQENLLQKANDLGQKLKDGLLAIAEKHPEIGDVRGLGAMIAIELFEDGDHNKPDAKLTAEIVARARDKGLILLSCGPYYNVLRILVPLTIEDAQIRQGLEIISQCFDEAKQ
What is the function of this protein?
Pyridoxal phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto acids.  Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA) and glutamate (PubMed:15723541, PubMed:30498244).  Thereby functions in a GABA degradation pathway that allows some E. coli strains to utilize GABA as a nitrogen source for growth (PubMed:12446648).  Also catalyzes the conversion of 5-aminovalerate to glutarate semialdehyde, as part of a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate (PubMed:30498244).
What are the official names of this protein?
4-aminobutyrate aminotransferase GabT, 5-aminovalerate transaminase, GABA aminotransferase, GABA-AT, Gamma-amino-N-butyrate transaminase, GABA transaminase, Glutamate:succinic semialdehyde transaminase, L-AIBAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: HBA_NASNA
Sequence: VLSPADKTNIKSTWEKIGSHASEYGGEALERTFASFPTTKTYFPHFDLSPGSAQVKAHGKKVAEALTNAVAHLDDLPGALSTLSDLHAYKLRVDPVNFKFLSHCLLVTLASHHPAEFTPAVHASLDKFFSSVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SPEB_SALPK
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHHRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLSAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPHHSVQIGIRTEFDKDNGFTVLDACQVNDRGVDDILAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: KAD_SHEHH
Sequence: MRIMLLGAPGAGKGTQAQFIMEKYGVPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERVAQDDCAAGFLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEDLAIRPDDEESTVRKRLDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTQSVATVSDEIVAVLS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_HELPJ
Sequence: MEQEICVIGFSGGQDSTTLAVWAKKRFKKVCLVGFDYAQKHSVELECAQKIASLLQLPYEIIPLDFLENITHSALFKNSNDLMGHSHAQNKDLPNSFVPNRNAIFITLLHSYAQKLGASNIALGVSQADFSGYPDCKEDFIKSIEHALNLGSNTAIKIVTPLMFLSKAQEFQMAKDLGVLDLIIKETHTCYQGERKILHAYGYGCDKCPACQLRKKGFEEFQAML
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: YBEY_BORPD
Sequence: MNPELSLSVQYGVAEPRLPRWRLRRWAQRALDGAARDGLAECARAELSLRLVGQAEGRRLNHAYRERDYATNVLTFEYGTDPLGTARGDIVICVPVLAREAREQGKTLLDHAAHLTVHGVLHALGYDHIKARDARRMEALETAILTGMRIADPYA
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C4S1A_XENLA
Sequence: MSDFWHKLGCCVVEKPQPKKKRKRIDRSMIGEPMNFVHLTHVGSGDMGAGDGLPMAGTVQQQMRSKCGRDRQWSNSRVL
What is the function of this protein?
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
What are the official names of this protein?
CDC42 small effector protein 1-A.
What is the protein family that this protein belongs to?
Belongs to the CDC42SE/SPEC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor.
Protein: PYRC_YERPG
Sequence: MTAQPQTLKIRRPDDWHIHLRDDEMLSTVLPYTSEVFARAIVMPNLAQPITTVASAIAYRERILAAVPAGHKFTPLMTCYLTNSLDAKELTTGFEQGVFTAAKLYPANATTNSTHGVSDIPAIYPLFEQMQKIGMPLLIHGEVTDAAVDIFDREARFIDQILEPIRQKFPELKIVFEHITTKDAADYVLAGNRFLGATVTPQHLMFNRNHMLVGGIRPHLFCLPILKRSTHQQALRAAVASGSDRFFLGTDSAPHAKHRKESSCGCAGVFNAPAALPAYASVFEELNALQHLEAFCALNGPRFYGLPVNDDVVELVRTPFLQPEEIPLGNESVIPFLAGQTLNWSVKR
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: SCRK_SALTM
Sequence: MNAKVWVLGDAVVDLLPESEGRLLQCPGGAPANVAVGVARLGGNSGFIGAVGGDPFGRYMRHTLQQEQVDVSHMYLDDQHRTSTVVVDLDDQGERTFTFMVRPSADLFLVEEDLPQFAAGQWLHVCSIALSAEPSRSTTFAAMESIRSAGGRVSFDPNIRPDLWQDQALLLACLDRALHMANVVKLSEEELVFISSSNDLAYGIASVTERYQPELLLVTRGKAGVLAAFQQKFTHFNARPVASVDTTGAGDAFVAGLLASLAANGMPTDMTALEPTLTLAQTCGALATTAKGAMTALPYQRDLNRQF
What are the official names of this protein?
Fructokinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: RPOS_ECOLI
Sequence: MSQNTLKVHDLNEDAEFDENGVEVFDEKALVEQEPSDNDLAEEELLSQGATQRVLDATQLYLGEIGYSPLLTAEEEVYFARRALRGDVASRRRMIESNLRLVVKIARRYGNRGLALLDLIEEGNLGLIRAVEKFDPERGFRFSTYATWWIRQTIERAIMNQTRTIRLPIHIVKELNVYLRTARELSHKLDHEPSAEEIAEQLDKPVDDVSRMLRLNERITSVDTPLGGDSEKALLDILADEKENGPEDTTQDDDMKQSIVKWLFELNAKQREVLARRFGLLGYEAATLEDVGREIGLTRERVRQIQVEGLRRLREILQTQGLNIEALFRE
What is the function of this protein?
Protects stationary phase cells from killing induced by endoribonuclease MazF.
What are the official names of this protein?
RNA polymerase sigma factor RpoS, Sigma S, Sigma-38.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP1_VICFA
Sequence: MTDGHLFNNITLGXRGGTNPGQIKIYSGGILWKRQGGGKTIDVDKTDIMGVTWMKVPKTNQLGVQIKDGLLYKFTGFRDQDVVSLTNFFQNTFGITVEEKQLSVTGRNWGEVDLNGNMLAFMVGSKQAFEVSLADVSQTNLQGKNDVILEFHVDDTTGANEKDSLMEMSFHIPSSNTQFVGDENRPSAQVFRDKIMSMADVGVGGEDAVVTFDGIAILTPRGRYSVELHLSFLRLQGQANDFKIQYSSVVRLFLLPKSNQPHTFVIISLDPPIRKGQTLYPHIVMQFETDTVVDSELAISEDLYNSKYKDKLELSYKGLIHEVFTTVLRGLSGGKVTKPGNFRSCQDGYAVKSSLKAEDGILYPLEKSFFFLPKPPTLILHEEIDYVEFERHAAGGSNMHYFDLLIRLKSEQEHLFRNIQRNEYHNLYGFISSKGLKIMNIADAQQAVGGVAKVLENDDDDAVDPHLERIRNEAGGDESDEEDSDFVIDKDDGGSPTDDSGADVSDASQSGGETEKPAKKEPKKDLSSKASSSKKKSKDADVDGVKKKQKKKKDPNAPKRALSGFMFFSQMERENLKKTNPGISFTDVGRVLGEKWKNLSAEEKEPYEAKAQADKKRYKDEISGYKNPQPMNVDSGNESDSA
What is the function of this protein?
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.  It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.  Binds specifically to double-stranded DNA (By similarity).
What are the official names of this protein?
FACT complex subunit SSRP1, Facilitates chromatin transcription complex subunit SSRP1, Recombination signal sequence recognition protein 1.
What is the protein family that this protein belongs to?
Belongs to the SSRP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: NRBF2_PONAB
Sequence: MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEAMKLTQSEQAHLSLELQRDSHMKQLLLIQERWKRAQREERLKAQQNTDKDVAAHLQTSHKPSAEDAEGQSPLSQKYSPSTEKCLPEIQGIFDRDPDTLLYLLQQKSEPAEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGPIEKELDVDADFVETSELWSLPPHSETATASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMNN
What is the function of this protein?
Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1).  However, effects has been described variably.  Involved in the induction of starvation-induced autophagy.  Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3.  Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1.  May be involved in autophagosome biogenesis.  May play a role in neural progenitor cell survival during differentiation (By similarity).
What are the official names of this protein?
Nuclear receptor-binding factor 2, NRBF-2.
What is the protein family that this protein belongs to?
Belongs to the NRBF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic vesicle, autophagosome.
Protein: Y1656_METJA
Sequence: MIISFEKLGEKYKIIDLNLNSIKQKIGDSLNIKEIKPTKIICVGLNYIDHAKELNMEIPEYPIIFLKPTSAIIYNEDYIIRPRISKRVDYEVELAIVIGKKCKNIKKDEANDYIMGYTILNDVTARDLQQKDGQWTRAKSFDTFCPIGPRIVKDIDPMNLNIECRVNGEIKQKSNTKNMIFDVYELVEFVASIMTLYPGDIISTGTPPGVGELKAGDVVECEIEGIGILRNYVKDEE
What are the official names of this protein?
Uncharacterized protein MJ1656.
What is the protein family that this protein belongs to?
Belongs to the FAH family.
Protein: RK16_RANMC
Sequence: MLSPKRTRFRKQHRGRMKGISYRGNRICFGGYALQALEPAWITSRQIEAGRRAMTRYARRGGKIWVRIFPDKPVTVRPAETRMGSGKGSPEFWVFVVKPGRILYEMGGVSEIVAREAISIAASKMPIRTQFIIAG
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KGD_MYCUA
Sequence: MANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYNPESTQEATEPAVVKPAAAPAKPAPAPAPAKPAAGPPAAGNGSPAAAPSAKPAAAPAKAPAPPPAEGDEMQVLRGAAAAVVKNMSASLDVPTATSVRAVPAKLLIDNRIVINNQLKRNRGGKISFTHLLGYALVQAVKKFPNMNRHYLDVDGKPNAVTPAHTNLGLAIDLQGKDGKRALVVAGIKRCETMRFAQFVTAYEDIVRRARDGKLTAEDFSGVTISLTNPGTIGTVHSVPRLMAGQGAIIGVGAMEYPAEFQGASEERIAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHQMLLADEFWDEIFRELSIPYLPVRWRPDNPDSIVDKNARIIELIAAYRNRGHLMADIDPLRLDKTRFRSHPDLDVCTHGLTLWDLDRSFKVGGCFAGPQNMKLRDVLSILRDTYCRHVGVEYTHILEPEQQQWLQQRVEAKHVKPTVAQQKYVLSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEYGLDEVVIGMPHRGRLNVLANIVGKPYSQIFSEFEGNLNPSQAHGSGDVKYHLGATGVYLQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLEHGETDTENQRAFSVVPMMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSTEYCTDVAKTIGAPIFHVNGDDPEACVWVARLAVDFRQRFNKDVIIDMLCYRRRGHNEGDDPSMTNPRMYDVVDTKRGVRKSYTEALIGRGDISIKEAEDALRDYQGQLEQVFNEVRELEKHGAQPSESVESDQMIPAGLATAVDKSLLARIGDAFLAVPDGFTTHPRVQPVLEKRREMAYEGKIDWAFAELLALGSLVAEGKLVRFSGQDTRRGTFSQRHSVIIDRHTREEFTPLQLLTTNKDGSPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSMLRNKAAVSDIKDFTEIKFRSVLEEPTYEDGVGDRNLVNRILLTSGKIYYEMVARKAKDKREDVAIVRVEQLAPLPRRRLRETLDRYPNAKEFFWVQEEPANQGAWPRFGLELPELLPEKLSGVKRISRRAMSAPSSGSSKVHAVEQQEILDTAFG
What is the function of this protein?
Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation.  Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA).  Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which spontaneously decarboxylates to form 5-hydroxylevulinate (HLA).  And is also a component of the 2-oxoglutarate dehydrogenase (ODH) complex, that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2).  The KG decarboxylase and KG dehydrogenase reactions provide two alternative, tightly regulated, pathways connecting the oxidative and reductive branches of the TCA cycle (By similarity).
What are the official names of this protein?
Multifunctional 2-oxoglutarate metabolism enzyme, 2-hydroxy-3-oxoadipate synthase, HOA synthase, HOAS, 2-oxoglutarate carboxy-lyase, 2-oxoglutarate decarboxylase, Alpha-ketoglutarate decarboxylase, KG decarboxylase, KGD, Alpha-ketoglutarate-glyoxylate carboligase.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.
Protein: PHK_RHILO
Sequence: MNDHTTIAASGGRLSDRELHDLDAYWRAANYLTIGQIYLLDNPLLREPLRLEHVKPRLLGHWGTSPGLSFIYAHLNRAIRLRDANVIYICGPGHGGPAMVANTYLEGTYSELNPDIAMDEQGMRKLFRQFSFPGGIPSHAAPDVPGSIHEGGELGYSLSHAYGAAFDNPDLVVACVVGDGEAETGPLAAAWHSNKFLNPARDGAVLPILHLNGYKIANPTILARIPEDELRALFAGYGYEPLFVAGHEPALMHQRMATVLDDAFDRISAIKHAARNGSGATGSRPEWPMIVLRSPKGWTGPKEVDGLKTEGFWRSHQVPLSGLAENPAHLKLLEEWLKSYRPEELFDAAGAPVASIRATAPQATKRMSANPHANGGLLRRSLELPGLHDHAVSLERPGAVKAESTRVMGSFLRDVMRLNEVAKNFRIVGPDETASNRLQDVFEVTERGWMEKILPEDVHLGREGRVLEILSEHTCQGWLEGYLLTGRHGLFSCYEAFIHIVDSMFNQHAKWLDACREIPWRRPIASLNYLLSSHVWHQEHNGFSHQDPGFIDVALNKKADIVRVYLPPDANTLLCVTDHVLQTWNRINVIVAGKPPSWQWLSMDKAIVHCRAGIGVWDWASTDDGAEPDVVMACAGDVPTLETLAAVQILRQQVPDLRIRVVNVVDLMTLQPKEYHPHGLSDREFDALFTPDKPVIFAYHGYPWTIHRLTYRRTNHDNIHVRGYNEEGTTTTPFDMTVLNGLDRFHIVQSVLDWVPRLKGVRVSLKQAMDSKLLEHRAYICSHGQDMPEILDWKWGQDPDAAPKRPD
What are the official names of this protein?
Probable phosphoketolase.
What is the protein family that this protein belongs to?
Belongs to the XFP family.
Protein: PRIO_TRAFR
Sequence: MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTSMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYEKESQAYYQRGSSMVFFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: LUXS_VIBC3
Sequence: MPLLDSFTVDHTRMNAPAVRVAKTMQTPKGDTITVFDLRFTMPNKDILSERGIHTLEHLYAGFMRNHLNGSQVEIIDISPMGCRTGFYMSLIGAPTEQQVAQAWLAAMQDVLKVESQEQIPELNEYQCGTAAMHSLEEAKAIAKNVIAAGISVNRNDELALPESMLNELKVH
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RL36_NITSB
Sequence: MKVRPSVKKMCEKCKIIKRKGVVRVICVNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: SECD_RHOM4
Sequence: MKRNGFKIGVTLALLLLCGYYLYPTVRYALLQRKLNRMSEEERAAFIEANYGTIQSLRERALKLGLDLQGGMHVTLEVRVDALIRELATDVDETFEEVLAAARERARSGDVSLIDAFVEEFERRDPNARLSRYFRNPDAGITRRSSNEEVAAYLRQQAEEAVNRAIEIIRDRVDRYGVTEPVIQKQGTRRIVVELPGVDDPERVRRLLRGTARLEFRLMADPQLLQAALQDIIAYYEPDTTAASETSAVTDTATADTSLAALLGEQPSPERPRNPLLAVMQPVGQGVVFGIVAGPDTAQVNRLLRNPEVQALLPSGIELLYTANPVGTDEQGRPLYYLLGVRKEVELTGEVITDARVEFDELNRPQVSMTMNSEGARIWARLTGANVGKHIAIVLDNVVYSYPVVNERIPSGRSSITGLDSREEAQDIVTVLKSGALPAPVDIIEERTVGPSLGEASIRAGLRSVLTGLLLVALFMIFYYRTGGMIADLALVLNIIFILGILAAFNATLTLPGIAGIVLTIGMAVDANVLIFERIREEQATGKTLRAAIDLGYSKAFSAIFDANITTFFTAAILYSFGVGPIQGFAVTLMAGIAASLFSAIVITRIIFDYLVLERKLMVSVG
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAD_STRZT
Sequence: MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQGFLPIENRKRGLEKALGHLENVEVVASHDELVVDVAKRLGATFLVRGLRNASDLQYEASFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPESILEEIRNEKKD
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.