PharMolix/UniProtQA huggingface dataset:
Protein: SF3B5_DICDI
Sequence: MSERESLNSQLEHLQMRYVGTGHADISKHEWLTNQHRDSLSSFIGHSSFLSLFSIAENESVGRVRYNTLTKMISPCGPAPKIKDNTMDKEEKND
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome.  SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.  Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.
What are the official names of this protein?
Splicing factor 3B subunit 5, SF3b5, Pre-mRNA-splicing factor SF3b 10 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the SF3B5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISCU_AZOVI
Sequence: MAYSDKVIDHYENPRNVGKLDAQDPDVGTGMVGAPACGDVMRLQIKVNEQGIIEDAKFKTYGCGSAIASSSLATEWMKGRTLEEAETIKNTQIAEELALPPVKIHCSVLAEDAIKAAVRDYKHKKGLV
What is the function of this protein?
A scaffold on which IscS assembles Fe-S clusters.  Cluster assembly on IscU homodimers proceeds sequentially from 1 2Fe-2S per dimer, to 2 2Fe-2S per dimer and finally 1 4Fe-4S per dimer.  Subsequently IscU transfers the Fe-S cluster to other acceptor proteins.  It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.  The clusters are very sensitive to O(2).
What are the official names of this protein?
Iron-sulfur cluster assembly scaffold protein IscU.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
Protein: MTNC_SACEN
Sequence: MSASVAARWVVLDIEGTLTPTSQVHVVLYDYARPRLGPWIHDHPEDPVVRKAVEDVKSEAGLPAEATAEQVVAVLHGWMDADRKAAPLKTLQGLIWQDGYARGELTTDYFADVVPALRAWRQRGLVLAVFSSGSVAGQVASFSHTTSGDLRGLFAQHFDTVNAGPKRERGSYEAIAAALGAARPLQIVFLSDVPAELDAAAQAGWHTVGLARPGEPYADADFGSHPAVGAFDDIDIEVVS
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: SRP54_SULIL
Sequence: MLENIRDAVRKFLTGSTPYEKAVDEFIKELQKSLISSDVNVKLVFSLTAKIKERLNKEKPPSVLERKEWFISIVYDELSKLFGGDKEPNVNPTRLPFIIMLVGVQGSGKTTTAGKLAYFYKRRGYKVGLVAADVYRPAAYDQLLQLGNQIGVPVYGEPNNQNAIEIAKKGVDTFVKNKMDIIIVDTAGRHGYGEETKLLEEMKEIYEALKPDDVILVIDASIGQKAYDLASRFHQASPIGSIIITKMDGTAKGGGALSAVAATGATIKFIGTGEKIDELEIFNAKRYVSRILGMGDIESILEKVKGLEEYEKIQKKMEDVMEGKGKLTLRDVYAQIMALRKMGPLSKVLQHIPGLGVMLPTPSEDQLKLGEEKIRRWLAALNSMTYKELENPSIIDKSRMRRIAEGSGLEVEDVRELLEWYNNMNKLLKMVKRRRGSIDKLFGGKIG
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle 54 kDa protein, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: FABZ_STRE4
Sequence: MMDIKQIQEALPHRYPMLLVDRILEASDDEIVAIKNVTINEPFFNGHFPQYPVMPGVLIMEALAQTAGVLELSKEENKGKLVFYAGMDKVKFKKQVVPGDQLVMTARFIKRRGTIAVVEAKAEVDGKLAASGTLTFAFGQ
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y806_HAEIN
Sequence: MAFSTIFILLICGICTNMVSAIFGIGGGVLMVPILRTLFPELPIQVISATSLTIVMCTALINLLFFHKQKIKIDYINMILWSIAMVIGVQIGFELSFYFSTAIISLIFTVSLSALAIKTFLNRSRIQIEVFNMSPIERAKGSISFCGGGLIAGITGIGGGSILAPLVGQLKGVKTQQIAVYTNYMMIIGGIGNLYGYLTRAFLYDASLSGQLGLNFLVVGVVTLGSFEMSFFSMKLRGLMNPVLTRKLLAIILFCIAAYMCILEFVFH
What are the official names of this protein?
Probable membrane transporter protein HI_0806.
What is the protein family that this protein belongs to?
Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CUE5_CONCL
Sequence: PVNEAGVERLFRALVGRGCPADCPNTCDSSNECSPNFPG
What are the official names of this protein?
Conotoxin Cl14.5.
What are the subcellular locations of this protein?
Secreted.
Protein: SURF4_CAEEL
Sequence: MNQFRAPGGQNEMLAKAEDAAEDFFRKTRTYLPHIARLCLVSTFLEDGIRMYFQWDDQKQFMQESWSCGWFIATLFVIYNFFGQFIPVLMIMLRKKVLVACGILASIVILQTIAYHILWDLKFLARNIAVGGGLLLLLAETQEEKASLFAGVPTMGDSNKPKSYMLLAGRVLLIFMFMSLMHFEMSFMQVLEIVVGFALITLVSIGYKTKLSAIVLVIWLFGLNLWLNAWWTIPSDRFYRDFMKYDFFQTMSVIGGLLLVIAYGPGGVSVDDYKKRW
What is the function of this protein?
Endoplasmic reticulum cargo receptor that mediates the export of the yolk proteins from intestinal cells by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:29643117).  Required for the endoplasmic reticulum export of the yolk protein vit-2, which is synthesized as a lipoprotein complex, from intestinal cells (PubMed:29643117).  Involved in endoplasmic reticulum exit sites (ERES) organization (PubMed:29643117).
What are the official names of this protein?
Surfeit locus protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the SURF4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Predominantly localizes at endoplasmic reticulum exit sites (ERES).
Protein: CPA_STRPY
Sequence: GFSIRAFGAEEQSVPNKQSSVQDYPWYGYDSYSKGYPDYSPLKTYHNLKVNLDGSKEYQAYCFNLTKHFPSKSDSVRSQWYKKLEGTNENFIKLADKPRIEDGQLQQNILRILYNGYPNDRNGIMKGIDPLNAILVTQNAIWYYTDSSYISDTSKAFQQEETDLKLDSQQLQLMRNALKRLINPKEVESLPNQVPANYQLSIFQSSDKTFQNLLSAEYVPDTPPKPGEEPPAKTEKTSVIIRKYAEGDYSKLLEGATLKLAQIEGSGFQEKIFDSNKSGEKVELPNGTYVLSELKPPQGYGVATPITFKVAAEKVLIKNKEGQFVENQNKEIAEPYSVTAFNDFEEIGYLSDFNNYGKFYYAKNTNGTNQVVYCFNADLHSPPDSYDHGANIDPDVSESKEIKYTHVSGYDLYKYAVTPRDKDADLFLKHIKKILDKGYKKKGDTYKTLTEAQFRAATQLAIYYYTDSADLTTLKTYNDNKGYHGFDKLDDATLAVVHELITYAEDVTLPMTQNLDFFVPNSSRYQALIGTQYHPNELIDVISMEDKQAPIIPITHKLTISKTVTGTIADKKKEFNFEIHLKSSDGQAISGTYPTNSGELTVTDGKATFTLKDGESLIVEGLPSGYSYEITETGASDYEVSVNGKNAPDGKATKASVKEDETVAFENRKDLVPPTGLTTD
What is the function of this protein?
Component of the pilus tip.  Can bind covalently, via its two reactive thioester bonds, to molecular targets from host cell surface and can thus mediate adhesion of the streptococcal pili to host cells.  Lysine side chains or a carbohydrate with a free amine group might be candidates for Cpa binding.  In vitro, can covalently bind to spermidine, but it is unlikely that spermidine is the natural target of Cpa.
What are the official names of this protein?
Pilus tip adhesin Cpa.
What are the subcellular locations of this protein?
Fimbrium.
Protein: GSA2_STAHJ
Sequence: MGYEKSIEAMKIAENLMPGGVNSPVRAFKSVDTPAIFMDHAKGSRIYDIDGNEYIDYVLSWGPLILGHKNEQVIKKLHEAVNRGTSFGASTLEENKLAELVIERVPSIEKVRMVSSGTEATLAALRLARGYTGRNKIIKFEGCYHGHSDSLLIKAGSGVATLGLPDSPGVPEGTAKNTITVPYNDLEAIKIAFENYGDDIAGIIVEPVAGNMGVVPPKDGFLQGLREITNDYGALLIFDEVMTGFRVGYNCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGRKEIMDKVAPVGNIYQAGTLSGNPLAMTSGYETLSQLTPESYEYFQELGDILEEGLKKVFSKHNVPITINRAGSMIGYFLNEGPVTNFEEANKSNLELFSQMYREMAKEGVFLPPSQFEGTFLSTAHSKEDIEKTIQAFDTALSRIV
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 2, GSA 2, Glutamate-1-semialdehyde aminotransferase 2, GSA-AT 2.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_DESPS
Sequence: MARIAGIDLPKNKHIDRALTYIHGIGLTSARKILDAVELPYTMNSDDLDGETVNRIRKVIEADYTVEGDRRREVSMDIKRLTDLGCYRGRRHRMGLPCRGQKTKTNARTRKGPRRGAARRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: RPIA_CHLSY
Sequence: MNTTSTETRKAMAAAAAVALVRPGMVIGLGFGSTAAYATRMIAERLHQGDLNDIVGVPCAEGTAQLARELGIPLTTLDEVAAVDLTIDGADEVDPQLSLIKGGGGALLREKMVAQASRRVAIIVDDSKLSPALGTRFALPLEVVDFGWRATARWLEAQGGTVQLRLRADGQPFRTDQGNLILDWKCGPLNDPAALAAQLSARAGIVEHGLFIGLATDLFVAGPDGVQHVTTSDCGTIAW
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: TAL_LEPIC
Sequence: MELYLDTANVDEIKEIASYGLVDGVTTNPSLIAKSGRSFKEVIKEICSIVSGPVSAEVLSTKFDGMMKEALELVEIAENVVIKVPLIPEGLKTVVELTKRNIPTNVTLCFSAPQALLAAKAGATFISPFIGRVDDTSWDGMELISEIREIYDNYGYDTRILAASIRGPIHLKESALRGADCATMPHSAFLQLFKHPLTDIGLEKFLEDSKKLKW
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABA_STRM5
Sequence: MTRLHAFNREQLLASARGELFGAAAGRLPNDPMLMFDRITEIREDGGPHGKGMVRAELDIRPDLWFFGCHFIGDPVMPGCLGLDAMWQLTGFFLTWLGAPGKGRALGCGEVKFTGQVLPDAKLVRYEIDISRVINRKLVMAQSDARMYVDDREIYSARDLRVGLFTETGSF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSAB1_STRR6
Sequence: MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKPLIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISKELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (By similarity).  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA/MsrB 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RBL_DIGPU
Sequence: MSPQTETKASVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEADQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIIMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGEREITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAQEGNEIIREACKWSPELAAACEVWKEIVFNFAAVDVLDK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLSX_ACAM1
Sequence: MGATRARIAIDAMGGDHAPDEIVAGALRAQAELDADVLLVGDPDRLEASIKSHSDSVPVEIIPSEGLIEMNEEPISALRRKRKASINVAMDLVKKKKADAVVSAGHSGAAMAAALLRLGRIPGIDRPAIGGVFPTIIAGKPVLVLDVGANVDCRPAFLDQFATMGTIYSEYVLGTEAPKVGLLNIGEESCKGNEVSVQTYQLLEQNPHVDFIGNAEGRDVLSGQFDVIVCDGFTGNILLKFAEAVGEVALQILREELPRGIHGKVGTGILKPNLRRIKQRMDHAEHGGGLLLGVAGVCIISHGSSQAPSIFNAIRLAKEAADNQVSQRIQSCYQQTVTAASNGE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RS10_HALLT
Sequence: MQQARVRLAGTSPEDLDDICADVREIADSTGVALSGPIPLPTKTLEIPSRKSPDGEGTATWEHWEMRVHKRLIDIDADERALRQLMRVQVPNDVSIEIVLED
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: LYS_BPJP3
Sequence: MGLKAKHKENLCSDSQRSKRLYVWIALAIVLSDFTSIFSHWIWGLLILILRTLMDLPTFVMNV
What is the function of this protein?
Induces the formation of specific membrane adhesion sites between the inner and outer membranes, apparently leading to host cell lysis.  Lysis may be performed via activation of host murein hydrolases.
What are the official names of this protein?
Lysis protein.
What are the subcellular locations of this protein?
Host cell inner membrane; Single-pass membrane protein. Host cell outer membrane; Single-pass membrane protein.
Protein: T1SI_HAEIN
Sequence: MKNNRTFLEKLLEGSEVEWKPLDEVANIVNNARKPVKSSLRVSGNIPYYGANNIQDYVEGYTHEGEFVLIAEDGSASLENYSIQWAVGKFWANNHVHVVNGKEKLNNRFLYHYLTNMNFIPFLAGKERAKLTKAKLQQIPIPIPPLSVQTEIVKILDALTALTSELTSELTSELTSELILRQKQYEYYREKLLNIDEMNKVIELGDVGPVRMCKRILKNQTASSGDIPFYKIGTFGKKPDAYISNELFQEYKQKYSYPKKGDILISASGTIGRTVIFDGENSYFQDSNIVWIDNDETLVLNKYLYHFYKIAKWGIAEGGTIQRLYNDNLKKVKISIPPLKEQHRIVSILDKFETLTNSITEGLPLAIEQSQKRYEYYRELLLNFS
What is the function of this protein?
A putative specificity subunit for a type I restriction enzyme; the corresponding endonuclease and methylase subunits have multiple frameshifts and are probably not expressed.
What are the official names of this protein?
Putative type I restriction enzyme specificity subunit S.HindORF215P, S protein, S.HindORF215P.
What is the protein family that this protein belongs to?
Belongs to the type-I restriction system S methylase family.
Protein: NKG2D_RAT
Sequence: MSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV
What is the function of this protein?
Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells.  Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity.  Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation.  Stimulates perforin-mediated elimination of ligand-expressing tumor cells.  Signaling involves calcium influx, culminating in the expression of TNF-alpha.  Participates in NK cell-mediated bone marrow graft rejection.  May play a regulatory role in differentiation and survival of NK cells.  Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
What are the official names of this protein?
NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NK lectin-like receptor, NKLLR, NKG2-D-activating NK receptor, NKR-P2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.
Protein: HRDE4_CAEEL
Sequence: MNTYFRFEWINGEENPCEYNLWRMFQIEPKPKSGANFMKPNLPNTENFSTASSSKIRQLSEQPSCSNSYKKLRHEMGSDNSNIDDPLDDYDDRKKKLAKKKAAFKAKKGYTTGQNKSDNSFEFEVEKSMDRKEPENGDEEESTEDDYRHAYSSVEKSLRKISLLPIQRPSHHTFCVFCSESYPPVEFHFCIFMTAAQKEVNQSVNEFLGKADTINKKMLESLKKFIHTSKVDTIAKHSRMENTSMKKNSDSPKKLKRPSTDPNPISKRFRHISDESTSSSSLAKNKSRSVTPDALPFAMIDSQEHRTQSGRVVKRPNLFCHKEVQIRKETVQKEGLKKKRVNKEKEVEQESTILLGISESERKRNRNMIRRLLANGFELPGDDYVLPPLPADKSTWTREQHKMDIYGPIYCALQSFKPAYTTDMTSEFLEDDGDTEFKSENSESDSDSEDEQKVENDVASSADDIEFIEIVEAERKMDQNLAQQVRSSFVTTAENTENNMLMEDDSSEQGSSKFNRNASRRSTENIEFITIDDDDDDDNDIEIIA
What is the function of this protein?
May play a role in transgenerational epigenetic inheritance.
What are the official names of this protein?
Protein hrde-4, Heritable RNAi deficient protein 4.
Protein: P5CR_AQUAE
Sequence: MHAIILTMRVGIVGFGNMGQAFALCFSKKLGKENIIVTDKVQEKRNLATEMGIAFASDVKFLADNSDVVLVAVKPKDSQEVLQKLKDYKGIILSIMAGVSIEKMEKILGKDKKIVRVMPNVNVAVGSGVMAITDNGNLSEEERSKVEELLLSCGTLYRIEERLFDAFTALAGSGPAFVFSFIDALALAGVHQGFSYEQALRIALDTVMGSAKLLKEFQVNPNELIAKVTSPGGTTIEGIKYLEEKGFKGTVMECINRTSQKAKKL
What is the function of this protein?
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR, PCA reductase.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTM_VIBCH
Sequence: MAVALLFILVIGMMIVGVPIAISLGLSSILFLLWHSDASLASVAQTLFNAFAGHYTLLAIPFFILASTFMSTGGVAKRIIRFAIAMVGWFRGGLAIASVVACMMFAALSGSSPATVVAIGSIVIAGMVKNGYSKEFAAGVICNAGTLGILIPPSIVMVVYSAATNVSVGRMFLGGVVPGLLAGLMLIIAIYITARIKNLPKQPFVGWKEALKAAKEASWGLLLVVIILGGIYGGIFTPTEAAAVAAVYSFFIANFIYRDMGPFADKTNTKPVLVKVVETFVHKDTKATLYDAGKLTIMLMFIIANALILKHVLTEERIPQMITESMLSAGLGPITFLIVVNLILLVGGQFMEPSGLLVIVAPLVFPIAIALGIDPIHLGIMMVVNMEIGMITPPVGLNLFVTSGVAKMSMMNVVKAALPWVGVMFLFLIIVTYVPWVSTWLPTLLMGPEIITR
What is the function of this protein?
Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake.
What are the official names of this protein?
C4-dicarboxylate TRAP transporter large permease protein DctM.
What is the protein family that this protein belongs to?
Belongs to the TRAP transporter large permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAA10_XENTR
Sequence: MSSPLEKPQIIAHVQKPVTYTLFDCKWIPCSAKFVCVGNLARGSGVLQVYEIQQGEAKLLQEAEKPKPIKCGTFGASSLQQRYLATGDFGGNLNIWNLEAPDTPVYSAKGHNEIINCIDGVGGVGIGEGAPEIVTGSRDGTVKVWDPRQKDTPVANMEPAAGETKRDCWTVAFGHAYNEQERLVCAGYDNGDIKLFDLRNMSVRWETNIKNGVCSLEFDRKDIVMNKLVATSLEGKFHVFDMRTQHPSKGFASMSEKAHKSTIWQVRHLPQNRDVFMTSGGAGNLHLWKYEYPAQRSRKDSDDVDMGVAGSVSLLQNVTLSTQPISSMDWSPDKKGLCVCTSFDQTVRVLIVTKLNKL
What is the function of this protein?
Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.
What are the official names of this protein?
Dynein axonemal assembly factor 10, WD repeat-containing protein 92.
What are the subcellular locations of this protein?
Dynein axonemal particle.
Protein: PSD_CHLTR
Sequence: MAAREMLYVNRETGKVEQERIICSSLVKFFIETRIGRALYSVLCKNSLFSRIVGWCQRLRVTRYFIKPFVTKYRICIEESASPLHDYASFNDFFVRKLKPDARPICQGEDICVTPADGAYLVFPSMADLSLFTIKNKPFSLESFLGDPQLAHQYAQGSMAIARLAPFDYHRFHFPIAGIAEAPRRINGHLFSIHPLMLKRNFEVFTENKREITIITSKEFGEVAYVEVGALNVGSIHQTFSPGSYVKKGAEKGFFAFGGSTVVLLFQPQRIIFDADLVGYSAQGLETRCRMGQSLGKRFSS
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type II sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YAZA_BACSU
Sequence: METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKVRRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL
What are the official names of this protein?
UPF0213 protein YazA.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: IL2_VULVU
Sequence: MYKMQLLSCIALMLVLVANSAPITSSSTKETEQQMEQLLLDLQLLLNGVNNYENPQLSRMLTFKFYTPKKATEFTHLQCLAEELKNLEEVLGLPQSKNVHLTDTKELISNMNVTLLKLKGSETSYNCEYDDETATITEFLNKWITFCQSIFSTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.