PharMolix/UniProtQA huggingface dataset:
Protein: RL22_SOLM1
Sequence: MEAKAIAKYIRLSPQKARLVAANILGRPVEEAMNILKFTPKKSAKIIGKVLHSAVANAEQISGVDIDNLTVKQVIINPGPTHKRIMTRSMGRAFRIVKRTSHITVVVAEN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL25_YEAST
Sequence: MAPSAKATAAKKAVVKGTNGKKALKVRTSATFRLPKTLKLARAPKYASKAVPHYNRLDSYKVIEQPITSETAMKKVEDGNILVFQVSMKANKYQIKKAVKELYEVDVLKVNTLVRPNGTKKAYVRLTADYDALDIANRIGYI
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  uL23 is a major component of the universal docking site for these factors at the polypeptide exit tunnel.
What are the official names of this protein?
60S ribosomal protein L25, Large ribosomal subunit protein uL23, RP16L, YL25, YP42'.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_STAES
Sequence: MAKQKIRIRLKAYDHRVIDQSAEKIVETAKRSGADVSGPIPLPTEKSVYTIIRAVHKYKDSREQFEQRTHKRLIDIVNPTPKTVDALMGLNLPSGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: COR1B_PONAB
Sequence: MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNRNGSLFCSACKDKSVRIIDPRQGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMAPGSSRLGAPASTTAAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGERICRLEEQLGRMENGDA
What is the function of this protein?
Regulates leading edge dynamics and cell motility in fibroblasts.  May be involved in cytokinesis and signal transduction (By similarity).
What are the official names of this protein?
Coronin-1B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat coronin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.
Protein: ACCD_BRUO2
Sequence: MNWITNYVRPKINSMLGRREMPENLWIKDPSTGEMVFHKDLESNQFVIPSSGHHMRIKAKDRLRFFFDNGEYTTLEAPKVPLDPLKFRDEKKYIDRLKDYRSRTGMDDAIVNGLGTIEGLPIVATVQDFSFMGGSLGMGAGEAIIQGFEKAIELKRPLVLFASSGGARMQEGILSLMQLPRTTVAVEMLKEAGLLYIVVLTNPTTGGVTASYAMLGDIHIAEPGALIGFAGPRVIEQTIREKLPEGFQSSEYLMEHGMVDMVVSRLELKATIARLLKIMTKQPANSDAPAPPEAGC
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_XYLFT
Sequence: MSVYAVGLTGGVACGKSLLAQLFEALNTTVVDADTIARQVVEPGPVLNCIVARFGSKILRADGCLDRRFLRQRVFADVAERKALEAIVHPVIRARLKQAAAAAAGPYVLVVIPLLAEAGGRIGYPWLQRILVVDAIPEVQHARLMQRDSIDAEQASLMIAAQIGRKERLAIADDIVFNDGDPAHLGGQVCNLDARYRALASVFSDVD
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_SULAC
Sequence: MLKINNDTKLFGVLGENIPYTLSPAIHNYAFQRLGINAVYLRFDVRRDKFHSIIIGLLNIASGLNVTIPYKEDVVKYLYGVSEEARVIGAVNTIHNLNGYNTDYIAIYNLIKEKLIDKPSICTVFGAGGAGRASIYALLKLGCEVYVINRSLERAQSLEKDFKEFGYDIKIISSCKPGDIIVNATPNSSYVPDECIKGKLVVDLVYNPVKTPLILKAEKTGIRSINGLEILVRQAMEAERIWFGKSLSDEEVVKFLYARKLVR
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: RBM22_MACFA
Sequence: MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYTQNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTITVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGALPPPPAAEEEASANYFNLPPSGPPAVVNIALPPPPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGAHAGKHSSP
What is the function of this protein?
Required for pre-mRNA splicing as component of the activated spliceosome.  Involved in the first step of pre-mRNA splicing.  Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.  Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
What are the official names of this protein?
Pre-mRNA-splicing factor RBM22, RNA-binding motif protein 22.
What is the protein family that this protein belongs to?
Belongs to the SLT11 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nearly exclusively nuclear. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.
Protein: DNAK_BUCAP
Sequence: MGKIIGIDLGTTNSCVAIMDGNKPRVLENSEGDRTTPSIIAYTEKGEVLVGQPAKRQAITNPKNTLFAIKRLIGRKFRDDEVQRDIKIMPYSIINSENGDAWIDVKKQKMAPPQISAEVLKKMKKTAEDYLGESIKEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKGEGNRTIAVYDLGGGTFDISIIEIDDVDKEKTFEVLATNGDTHLGGEDFDSRLINYLVQEFKKEQGIDLRNDSLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADSNGPKHLNIKVTRSKLESLVEDLVMRSIEPLKVALKDAGLSVGDINDVILVGGQTRMPMVQSKVADFFGKEPRKDVNPDEAVAVGAAVQGGVLSGDVKDVLLLDVTPLSLGIETMGGIMTSLINKNTTIPTKHSQVFSTAEDNQSAVTIHILQGERKRALDNKSLGQFNLDGIEPAPRGTAQIEVTFDIDSDGILHVSAKDKKTGKEQKITIKASSGLNEEEIKKMINDAEANSEADRKFEELIQVRNQGDQLIHSIRKQLDENKNQIEKKELEKIKSALDELERSLKGENKSEIEKNIQNLLNISSKLTEINQKKSEENLKKEDTSSESKKDENVVDAEFEEIKDPKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL36_VARPS
Sequence: MRVSASVKTICRNCKVIRRKGVVRVICTDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: PURA1_CAPFR
Sequence: MNISILRLDSNPITTATSPATATANHRSGILGCYNGTYSCRLNQLQQRKKNPSIIVCSTTKPLASVVDRHGVSESGLSRIESLSQVSGVLGCQWGDEGKGKLVDILAKHFDIVARCQGGANAGHTIYNSEGKKFALHLVPSGILNEETVCVIGNGVVVHLPGLFKEIDGLESNGVSCQGRILVSDRAHLLFDFHQEIDGLREAELAKSFIGTTKRGIGPCYSSKVIRNGIRVSDLRHMDTFPQKLDRLLSDAAARFPGFKYGPEMLREEVERYKKFAERLEPFITDTVHFMNDAISQKKKILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPRVVGDLVGVVKAYTTRVGSGPFPTEIMGKGGDLLRFAGQEFGTTTGRPRRCGWLDIVALRYCCQINGFASLNLTKLDVLSDLSEIQLGVTYRHPDGSILNSFPSDLRLLEQLKVEYEVLRGWQSDISSIRKYSDLPKSAREYVERIEELVGVPIHYIGIGPGRDALIYK
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase 1, chloroplastic, AMPSase 1, AdSS 1, IMP--aspartate ligase 1.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: T150C_RAT
Sequence: MDGKKCSVWMFLPLVFTLFTSAGLWIVYFIAVEDDKILPLNSAARKSGVKHAPYISFAGDDPPASCVFSQVMNMAAFLALVVAVLRFIQLKPKVLNPWLNISGLVALCLASFGMTLLGNFQLTNDEEIHNVGTSLTFGFGTLTCWIQAALTLKVNIKNEGRRAGIPRVILSAVITLCVVLYFILMAQDIHMYAARVQWGLVMCFLAYFGTLAVEFRHYRYEIVCSEYQENFLSFSESLSEASEYQTDQV
What is the function of this protein?
Component of a mechanosensitive cation channel.  Confers mechanically activated (MA) currents with slow inactivation kinetics.  May contribute to proprioception.
What are the official names of this protein?
Transmembrane protein 150C.
What is the protein family that this protein belongs to?
Belongs to the DRAM/TMEM150 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker.
Protein: PROA_RHOP2
Sequence: MTASLKAIDGSAELATLMHDLGRRARAAARVLALASPEQKNRALEAMERAIRAGADKILAANAEDVADANASGANSAFLDRLTLTPARVEAMAEGIAVVRGIPDPVGAVTESWQRPNGMTIERVRVPLGVVAVIYESRPNVTADAGVLCLKSGNAVILRGGSESFRSGRAIHDCLVQGLREAGLPEAAITLVPTRDRAAVGLLLGGLNGSVDVIVPRGGKSLVARVESEARVPVFAHLEGVNHVYIDRSADLDMAKSIVLNAKMRRTGVCGAAETLLIDRAAADTHLAPLVAMLIDAGCEVRGDAIVQHADARVKPATDQDWDTEYLDAVIAAKVVDDVDDAIVHIHDHGSHHTDAIVAEDAQTAAKFLGEVDSAIVLHNASTQFADGGEFGFGAEIGIATGKFHARGPVGAEQLTTFKYRIHGTGQTRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VGA8_ALHV1
Sequence: MDNYTLALNCNHTTHGYAHYVYSTLSYLVFIGNAPGYPNCENCIYDITFNSTSMLNISNNYFHIANATLGAPEYPEQPVTLSVIGEESPWVAWLAVHTPDKNYTEDANTARAVMRVLDPFNISWCAVYNVQSVDPTDTQDISNCTEVSEELPVNNQKSSIHLNTYFLNSTFTVSVSLNASNISSQCSGNVSLENMTSNVHIPCPTLPLTVSVKASTDNMQTGAAVNASIDIGWLLQNLTDASLTVSSSPGNLTQKNCTTYKNISKTDRHVRDENLYVLAQIPALEGHKDSFTLTRSPILLNFSRNSSEFQLVLYDRNSSCVWANPANGTDTILVSMSCPHITATISPRGEIKVNVTGNFSRNANLSLAFLSSKGKEYAGVLLQAFEPSTRPPPGTVAPGILSTTANFETSTNKSSPTYTPTPAKLSTPPGLTNTLLLTAGEHNSGIGSTLEPLTTVSVQVLQTPSSPTRDTSTLVIKLTTVPQDHKTVSPSLVTPGRTSTLPIVSMTHFSREGSSPKPQTTAAKTSSEASLPPLLTTTPTPTNTEKSQSTFASSTVSVDTTFTGDDVNTVGTMSPSITQTLPITPTSGRQYIVVGCCTLNRRSGNLFFFFLFVAAHRESGHNTSMPNPHHNSVKPEDHPHHPEGDHPDADHHERFQIWLLPIAGTIFALVALVIVNIALRMTE
What are the official names of this protein?
Uncharacterized gene A8 protein.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: PBS1_ARATH
Sequence: MGCFSCFDSSDDEKLNPVDESNHGQKKQSQPTVSNNISGLPSGGEKLSSKTNGGSKRELLLPRDGLGQIAAHTFAFRELAAATMNFHPDTFLGEGGFGRVYKGRLDSTGQVVAVKQLDRNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEFMPLGSLEDHLHDLPPDKEALDWNMRMKIAAGAAKGLEFLHDKANPPVIYRDFKSSNILLDEGFHPKLSDFGLAKLGPTGDKSHVSTRVMGTYGYCAPEYAMTGQLTVKSDVYSFGVVFLELITGRKAIDSEMPHGEQNLVAWARPLFNDRRKFIKLADPRLKGRFPTRALYQALAVASMCIQEQAATRPLIADVVTALSYLANQAYDPSKDDSRRNRDERGARLITRNDDGGGSGSKFDLEGSEKEDSPRETARILNRDINRERAVAEAKMWGESLREKRRQSEQGTSESNSTG
What is the function of this protein?
Protein kinase required for plant defense mechanism mediated by the disease resistance (R) protein RPS5.  In case of infection by Pseudomonas syringae, AvrPphB triggers RPS5-mediated defense mechanism via the cleavage of PBS1.  Both kinase activity and cleavage by avrPphB are independently required to trigger the RPS5-mediated resistance.  Contributes to PAMP-triggered immunity (PTI) signaling and defense responses downstream of FLS2.
What are the official names of this protein?
Serine/threonine-protein kinase PBS1, AvrPphB susceptible protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GATC_ACIAC
Sequence: MALTPQDIGRIANLARLELSPAESERMLTQLNGFFGIVEKMRAVDTAGLEPLSHPVAAIQDIALRLREDTASEPDQREANQRSAPAVERGLFLVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: UPPP_DESHD
Sequence: MALVEIFKAILLGIVEGITEWLPISSTGHMILVDEFIKLNMSAAFMEMFFVVIQLGAILAVVLLYWKKLNPFTFDRGVSVKQETIEMWFKIIVSCIPAGVIGLLWDDVFNALFYNYQTVAVMLIIFGILFIVIENYNKGKRPRVNHLSQITYTTAFMIGIFQLIAAIFPGTSRSGATIVGGLLLGVSRTVAAEFTFFLAIPVMFGASALKLLKFGFNFTGPELMILLIGMVVAFIVSVISIKFLMGYIKKNDFKIFGWYRIILGVIVLLYFSARTIIG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: S35F5_HUMAN
Sequence: MVPPRRHRGAGRPGVLSSSPPFRLRSAKFSGIALEDLRRALKTRLQMVCVFVMNRMNSQNSGFTQRRRMALGIVILLLVDVIWVASSELTSYVFTQYNKPFFSTFAKTSMFVLYLLGFIIWKPWRQQCTRGLRGKHAAFFADAEGYFAACTTDTTMNSSLSEPLYVPVKFHDLPSEKPESTNIDTEKTPKKSRVRFSNIMEIRQLPSSHALEAKLSRMSYPVKEQESILKTVGKLTATQVAKISFFFCFVWFLANLSYQEALSDTQVAIVNILSSTSGLFTLILAAVFPSNSGDRFTLSKLLAVILSIGGVVLVNLAGSEKPAGRDTVGSIWSLAGAMLYAVYIVMIKRKVDREDKLDIPMFFGFVGLFNLLLLWPGFFLLHYTGFEDFEFPNKVVLMCIIINGLIGTVLSEFLWLWGCFLTSSLIGTLALSLTIPLSIIADMCMQKVQFSWLFFAGAIPVFFSFFIVTLLCHYNNWDPVMVGIRRIFAFICRKHRIQRVPEDSEQCESLISMHSVSQEDGAS
What is the function of this protein?
Putative solute transporter.
What are the official names of this protein?
Solute carrier family 35 member F5, Hepatitis C virus NS5A-transactivated protein 3, HCV NS5A-transactivated protein 3.
What is the protein family that this protein belongs to?
Belongs to the SLC35F solute transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KITHA_ARATH
Sequence: MATLKASFLIKTLDSDVTGDFLSDLERRGSGAVHVIMGPMFSGKSTSLLRRIKSEISDGRSVAMLKSSKDTRYAKDSVVTHDGIGFPCWALPDLMSFPEKFGLDAYNKLDVIGIDEAQFFGDLYEFCCKVADDDGKIVIVAGLDGDYLRRSFGAVLDIIPIADSVTKLTARCEVCGHKAFFTLRKNCDTRTELIGGADVYMPVCRKHYITNHIVIKASKKVLEDSDKARAESCVAATI
What is the function of this protein?
Part of the salvage pathway for purine and pyrimidine deoxyribonucleotide synthesis.  Phosphorylates preferentially purines over pyrimidines (PubMed:22897443).  Mediates tolerance to genotoxins, such as ultraviolet-C (UV-C) irradiation, MMC, a DNA crosslinker, and ZEO, a DNA intercalator, that induce double-strand breaks and thus contributes to several DNA repair pathways by providing deoxythymidine triphosphate that serve as precursors for DNA repair and to balance deoxyribonucleotides pools (PubMed:25537647).
What are the official names of this protein?
Thymidine kinase a, AtTK1a.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_STAAB
Sequence: MRELTKRQSEIYNYIKQVVQMKGYPPSVREIGEAVGLASSSTVHGHLSRLEEKGYIRRDPTKPRAIEIVSDQTNDNINMEETIHVPVIGKVTAGVPITAVENIEEYFPLPEHLTSTHNSDIFILNVVGDSMIEAGILDGDKVIVRSQTIAENGDIIVAMTEEDEATVKRFYKEKNRYRLQPENSTMEPIYLDNVAVIGKVIGLYREM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: HRG_RABIT
Sequence: ATLQCSWALTPTDCKTTKPLAEKALDLINKWRRDGYLFQLLRVADAHLDGAESATVYYLVLDVKETDCSVLSRKHWEDCDPDLTKRPSLDVIGQCKVIATRYSDEYQTLRLNDFNCTTSSVSSALANTKDSPVLFDFIEDTEPFRKSADKALEVYKSESEAYASFRVDRVERVTRVKGGERTNYYVDFSVRNCSRSHFHRHPAFGFCRADLSFDVEASNLENPEDVIISCEVFNFEEHGNISGFRPHLGKTPLGTDGSRDHHHPHKPHKFGCPPPQEGEDFSEGPPLQGGTPPLSPPFRPRCRHRPFGTNETHRFPHHRISVNIIHRPPPHGHHPHGPPPHGHHPHGPPPHGHPPHGPPPRHPPHGPPPHGHPPHGPPPHGHPPHGPPPHGHPPHGPPPHGHPPHGHGFHDHGPCDPPSHKEGPQDLHQHAMGPPPKHPGKRGPGKGHFPFHWRRIGSVYQLPPLQKGEVLPLPEANFPQLLLRNHTHPLKPEIQPFPQVASERCPEEFNGEFAQLSKFFPSTFPK
What is the function of this protein?
Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions.  Inhibits rosette formation.  Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis.  Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway.  This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions.  Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes.  Binds T-cells and alters the cell morphology Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity).  Tethers plasminogen to the cell surface.
What are the official names of this protein?
Histidine-rich glycoprotein, Histidine-proline-rich glycoprotein, HPRG.
What are the subcellular locations of this protein?
Secreted.
Protein: GBA3_CAVPO
Sequence: MAFPADLVGGLPTAAYQVEGGWDADGRGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSISWSRLLPDGTTGFINQKGVDYYNKIIDDLLTNGVTPVVTLYHFDLPQALEDQGGWLSEAIIEVFDKYAQFCFSTFGNRVRQWITINEPNVLCAMGYDLGFFAPGVSQIGTGGYQAAHNMIKAHARAWHSYDSLFREKQKGMVSLSLFCIWPQPENPNSVLDQKAAERAINFQFDFFAKPIFIDGDYPELVKSQIASMSEKQGYPSSRLSKFTEEEKKMIKGTADFFAVQYYTTRFIRHKENKEAELGILQDAEIELFSDPSWKGVGWVRVVPWGIRKLLNYIKDTYNNPVIYITENGFPQDDPPSIDDTQRWECFRQTFEELFKAIHVDKVNLQLYCAWSLLDNFEWNDGYSKRFGLFHVDFEDPAKPRVPYTSAKEYAKIIRNNGLERPQ
What is the function of this protein?
Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (Probable).  Has a significant glucosylceramidase activity in vitro.  However, that activity is relatively low and its significance in vivo is not clear (By similarity).  Hydrolyzes galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph.  However, the in vivo relevance of these activities is unclear (By similarity).  It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (Probable).  Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor (By similarity).  Could also play a role in the catabolism of cytosolic sialyl free N-glycans (By similarity).
What are the official names of this protein?
Cytosolic beta-glucosidase, Cytosolic galactosylceramidase, Cytosolic glucosylceramidase, Cytosolic glycosylceramidase, Cytosolic GCase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SPXN1_DANRE
Sequence: MKDLRTLAAYALALLLLATFVSHSWSAPKGSFQRRNWTPQAMLYLKGTQGRRFVSEDRNEGDLYDTIRLESRSQNTENLSISKAAAFLLNILQQARDEDEPY
What is the function of this protein?
Acts as a ligand for galanin receptors galr2a and galr2b (PubMed:24517231).  Brain administration of the peptide inhibits food consumption and elevates levels of glucose, triacylglycerol and cholesterol in the serum (PubMed:29116147).  Likely to control food intake by regulating appetite related genes which includes the negative regulation of the orexigenic factor agrp (PubMed:29116147).  By controlling food intake it may act as a satiety factor in energy metabolism (PubMed:29116147).
What are the official names of this protein?
Spexin prohormone 1, Neuropeptide Q, Spexin hormone.
What is the protein family that this protein belongs to?
Belongs to the spexin family.
What are the subcellular locations of this protein?
[Spexin-1]: Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle.
Protein: EFTS_CLOTE
Sequence: MITAKMVKELREITGAGMMDCKKALTETNGDTEKAVEVLREKGLAAAAKKSGRIAAEGLVETYIAEDKKNASIVEVNCETDFVAANEEFKGLVANIAKQAANTKAEDVDSFIEEKYIGSEEGTIKDAVTALVAKLGENMSVRRFKQLSVENGIIESYIHGDGKIGVLVELECEKESEVLSEVAKDVAMQVAAVNPPFLDRTFVDEETLDKEREIYRVQALNEGKPEKIVDKMVEGRIQKYYKENCLVEQVWVRNSDYTIDKYVKEKSKEVGADIKVANFVRFEKGEGIEKKEEDFAEEVKKQMQ
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MANP_ARATH
Sequence: MKCLCFIVLLAIVIAQSYVGVEAAPSDGFVSRNGVQFILNGKPFYANGFNAYWLAYEATDPATRFKITNVFQNATSLGLTIARTWGFRNGAIYRALQTAPGSYDEQTFQGLDFGIAEAKRVGIKLIIPLVNNWDDYGGKKQYVDWARSKGEMVSSNDDFYRNPVIKEFYKNHVKTMLNRVNTFTKVAYKDEPASMAWQLMNEPRCGVDRSGKTLMAWINEMALFVKSVDPNHLLSTGHEGFYGDSSPERKNSLNPVSANTVGADFIANHNIDAIDFASMHCGSDLWFQRLDQNSRLAFIKRWLEGHIEDAQNNLKKPVILAEFGLGSDTPRYTLANRDDVFTTTYDIIYISTQKGGSAAGALFWEVISEGVSNFAGPSSIILSDKSSTVNIISEQRRKMGLLGGTKGK
What are the official names of this protein?
Putative mannan endo-1,4-beta-mannosidase P, Beta-mannanase P, Endo-beta-1,4-mannanase P, AtMANP.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.