PharMolix/UniProtQA huggingface dataset:
Protein: PEX5_XENLA
Sequence: MAMRGLIEAECGGSNPLMKLTNHFTQDKALREEGLQHVSWPPGATVVSKPLGEATEDELVSEFLHTRAPSLQSRAPHTFKMDGLLAEMQEIEQSSFRPEPLRAPGVADLALSEQWSAEFLGVEVDPVEEEDWSREFTEQADPHASPSRWAEEYLQQSEEKLWLGESEGAMAEKWTEEYQPEDDLQREAKSLVSQVTDPKLANTQFLQFVKRIGDGELSFSHAPSTPSQTVSQAEQWSEQFVHEQAEQWVDQFAPLEKDFEKAKAAVESDVDFWDKLQEEWEEMAKRDAEAHPWLSDFQDLSSKSIDKGYMFEDNNPFSEVSLPFEEGLKHLREGDLPSAVRLFEVAVKRDPQHMEAWQYLGTTQAENEQELAAISALRRCIDLKPDNLSALMALAVSYTNECLQQQACHTLREWLRHNPKYSHLVKEESSSNASRARSFGTLLSDSVFSDVRELFLSAVNSDPSQVDPDVQCGLGVLFNLSGEYQKAVDCFTAALGQRPDDYLLWNKLGATLANGNDSEAAVEAYRRALQLQPGFIRSRYNLGIACINLGAHREAIEHFLEALSMQQQSGGCESAMSDNIWSTLRMALSMIGQSDLYSSADARDLATLQAAFPPHSAAQ
What is the function of this protein?
In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with pex7.  Interaction with pex7 only takes place when pex7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal.  Pex7 along with PTS2-containing cargo proteins are then translocated through the pex13-pex14 docking complex together with pex5.
What are the official names of this protein?
Peroxisomal targeting signal 1 receptor, PTS1 receptor, PTS1R, PTS1-BP, Peroxin-5.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal targeting signal receptor family.
Protein: FXD3B_XENLA
Sequence: MTLSSSGSASDMSGQTVLSADDADIDVVGEGDEALDKDSECESPVGHHDEVDALGGKEIPRSPSGSSTDAEGKGESQQQQQEGIQNKPKNSVVKPPYSYIALITMSILQSPQKKLTLSGICEFISSRFPYYREKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRQQQDTLREQTALMMQSFGAYSLASPYGRHYGLHPAAYTHPAALQYPYIPPVGPMLPPAVPLLPSSELTRKAFSSQLSPSLQLQLSSLSSTAASIIKSEPSSRPSFSIENIIGVSAASSVAPQTFLRPPVTVQSALMSHQPLVLSRSTAAIGPILSVPTNLISGQFLPTAATAVAKWPAQ
What is the function of this protein?
Transcriptional repressor that is an essential upstream regulator of neural crest determination and mesoderm induction.  Functions by recruiting the transcriptional corepressor tle4.  Also acts in a negative auto-regulator loop by inhibiting the transcription of its own gene.
What are the official names of this protein?
Forkhead box protein D3-B, FoxD3-B, FoxD3b, Fork head domain-related protein 6', xFD-6'.
What are the subcellular locations of this protein?
Nucleus.
Protein: FCG3A_CRIGR
Sequence: MSVWTSRKAAEDNDTSLSSGIRAGLQKAVVTLHPEWVRVLQDDSVTLRCQGTYPPGDNSTKWFHNGSLTLQQDANYLIGSAKVKDSGEYTCQTALSMLSDPVNLEVHIGWLLLQTTQRPVFREGDPIRLNCHSWRNTPVYKVTYLQNGKGKKYFHKNSELHIPNATQNHSGSYFCRGIIGRNNKSSETLRITVGDLTSPSTFPPWHQITFCLLIGLLFTIDTVMYFSVQKGLRRSTADYEEPEVHWSKEPENKTISEEKQSFRSSRANSETPENR
What is the function of this protein?
Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).  Binds with intermediate affinity to both IgG2a and IgG2b.  Can bind to IgG2a and IgG2b monomers.  Does not display binding to IgG1 or IgG3 (By similarity).  Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC).  Confers protection to lethal influenza virus infection (By similarity).  On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (By similarity).  Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (By similarity).  Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (By similarity).  Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE).  Binds with low affinity to both the a and b allotypes of IgE.  Has also been shown to bind to IgE allotype a only but not to allotype b.  Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes.  Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (By similarity).  Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821).
What are the official names of this protein?
Low affinity immunoglobulin gamma Fc region receptor III-A, IgG Fc receptor III-A, CD16-2, FcgammaRIV.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: BARS_ARATH
Sequence: MEALGNFDYESYTNFTKLPSSQWGDQFLKFSIADSDFDVLEREIEVLKPKVRENIFVSSSTDKDAMKKTILSIHFLDSLGLSYHFEKEIEESLKHAFEKIEDLIADENKLHTISTIFRVFRTYGYYMSSDVFKIFKGDDGKFKESLIEDVKGMLSFYEAVHFGTTTDHILDEALSFTLNHLESLATGRRASPPHISKLIQNALHIPQHRNIQALVAREYISFYEHEEDHDETLLKLAKLNFKFLQLHYFQELKTITMWWTKLDHTSNLPPNFRERTVETWFAALMMYFEPQFSLGRIMSAKLYLVITFLDDACDTYGSISEVESLADCLERWDPDYMENLQGHMKTAFKFVMYLFKEYEEILRSQGRSFVLEKMIEEFKIIARKNLELVKWARGGHVPSFDEYIESGGAEIGTYATIACSIMGLGEIGKKEAFEWLISRPKLVRILGAKTRLMDDIADFEEDMEKGYTANALNYYMNEHGVTKEEASRELEKMNGDMNKIVNEECLKITTMPRRILMQSVNYARSLDVLYTADDVYNHREGKLKEYMRLLLVDPILL
What is the function of this protein?
Involved in the biosynthesis of over 15 sesquiterpenes (C15).  The major products are (+)-alpha-barbatene (27. 3%), (+)-thujopsene (17. 8%) and (+)-beta-chamigrene (9. 9%).  Can use farnesyl diphosphate or geranyl diphosphate as substrates, but not geranylgeranyl diphosphate.
What are the official names of this protein?
Alpha-barbatene synthase, AtBS, Beta-chamigrene synthase, Terpeneoid synthase 11, AtTPS11, Thujopsene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_YERPB
Sequence: MYYPLVRKALFQLDPERAHELTFRQLKRVSGTPLEFLVRQSVPTKPVSCMGLSFKNPVGLAAGLDKDGECIDALGAMGFGFIEVGTVTPRPQVGNDKPRLFRIVEAEGLINRMGFNNHGVDNLIENVKKSHFGGILGINIGKNKDTPVEQGKEDYLICMDKIYPYAGYIAINISSPNTPGLRSLQYGEALDDLLAAIKDKQTELHQRHHKYVPVAVKIAPDLTEEELIQIADSLVRHNIDGVIATNTTLDRSLIQGLNYCEQAGGLSGRPLQLRSTEVIHRLSQELKGRLPIIGVGGIDSVTAAREKMAAGASLIQIYSGFIFRGPGLIKNIVTHI
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL23_RHOOB
Sequence: MSTIADPRDILLAPVISEKSYGLIEEGTYTFLVHPDSNKTQIKIAVEKIFGVTVTSVNTANRQGKRKRTRFGYGKRKDTKRALVTLSADSKPIEIFGGPVA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RMD1_CAEEL
Sequence: MESFATSDKLFESREFVKGLEELKKRREDGEMTCDLLWRMCRFCHELSTTMSGEQRRKMLIEGRDYGLEAMDLDPSSFLAAKWTAIMFGLVVDQLPTKEKINDGGRLKDMLDKALELDPTDFALLHLRARFSYTIANLSWLERKAASMLYSEVPKATIDDALVDFKAAYNQNADWIENLLFLSKCHLAKKEKQQAREMLNKAIVLPAASSNDAQFVTECKSLLQKC
What is the function of this protein?
Acts in chromosome segregation and organization during mitosis.
What are the official names of this protein?
Regulator of microtubule dynamics protein 1.
What is the protein family that this protein belongs to?
Belongs to the FAM82/RMD family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole.
Protein: PROB_XANAC
Sequence: MLKVGSSLLAADGGGLSPRFALGLAQFVSANLAAGRELVIVSSGAVAAGRAILPKAMDVGAPIAARQALAALGQAQLIALWQRFFERPVAQVLLTHDDLRNRRRYLNARATLGELLRLGALPVINENDTVSVDELKLGDNDNLAAIVAALVDADALFIATDIDGLYSADPRSNPLARPLDDVPELTPEVLAMAGGSGSNVGTGGMRTKLEAAAKAGAAGIETYLFNGRSGEVVRALALDRLRGTRIHAARTRIAARKYWLRHAPVEAGAILIDDGAAAALTGKGASLLPGGVAGAQGDFRRGDMVEIRRRDTTGDGQCLARGVSQYSALDIRRIAGRHSREIENVLGYSYGENVVHRDDLVVL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHA2_STAAM
Sequence: MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYTYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSSPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
What is the function of this protein?
May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.
What are the official names of this protein?
Alanine dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
Protein: SYS_VESOH
Sequence: MLSKKQLRLDMKAVANALKKRYFYFDVDHLIELESNRKKNQIETQNLQNLRNMQSKAIGKAKASGEDIKSLLKNVSDLSTKLNLAKSNLQLIQSEIDVIVLSMPNIPHHSVPNGKSEEDNIEVSKWGKLVNYDFDVKDHVDLGAMYGLDFETAVKISGARFSVMTGKIARLHRALTQFMLDRHSEVNGYTEAYVPYLVNTESLIGTGQLPKFEADLFKTYLHGEKGETKTLYLIPTGEVPVTNMMRDMIIKENDLPLKFVTHTPSFRSEAGSYGRYTRGLIRQHQFEKVELVQVVKAQDSYQALEVLTTHAEDILQALELPYRKISLCAGDLGFSATKTYDLEVWLPGQNVYCEISSCSCFEDFQARRLQLRYKNKETNKLELLHTLNGSGLAVGRTLVAVLENHQQADRSIKIPFVLQSYMGGLEVMN
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPME1_ARATH
Sequence: MGYTNVSILLGLLMVFVTPMVFADDVTPIPEGKPQVAQWFNANVGPLAQRKGLDPALVAAEAAPRIINVNPKGGEFKTLTDAIKSVPAGNTKRVIIKMAPGEYKEKVTIDRNKPFITLMGQPNAMPVITYDGTAAKYGTVDSASLIILSDYFMAVNIVVKNTAPAPDGKTKGAQALSMRISGNFAAFYNCKFYGFQDTICDDTGNHFFKDCYVEGTFDFIFGSGTSMYLGTQLHVVGDGIRVIAAHAGKSAEEKSGYSFVHCKVTGTGGGIYLGRAWMSHPKVVYAYTEMTSVVNPTGWQENKTPAHDKTVFYGEYKCSGPGSHKAKRVPFTQDIDDKEANRFLSLGYIQGSKWLLPPPAL
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.  Involved in the pollen tube growth and determination of pollen tube morphology.
What are the official names of this protein?
Pectinesterase PPME1, AtPPME1, PE PPME1, Pectin methylesterase 9, AtPME9, Pectin methylesterase PPME1, Protein POLLEN SPECIFIC PME 1.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Secreted, cell wall.
Protein: Y2203_MYCTO
Sequence: MPGPHSPNPGVGTNGPAPYPEPSSHEPQALDYPHDLGAAEPAFAPGPADDAALPPAAYPGVPPQVSYPKRRHKRLLIGIVVALALVSAMTAAIIYGVRTNGANTAGTFSEGPAKTAIQGYLNALENRDVDTIVRNALCGIHDGVRDKRSDQALAKLSSDAFRKQFSQVEVTSIDKIVYWSQYQAQVLFTMQVTPAAGGPPRGQVQGIAQLLFQRGQVLVCSYVLRTAGSY
What are the official names of this protein?
Uncharacterized protein MT2259.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TKL3_LOCMI
Sequence: APQAGFYGVR
What is the function of this protein?
Myoactive peptide.  Stimulates the contraction of the oviduct and foregut.
What are the official names of this protein?
Locustatachykinin-3, Locustatachykinin III, TK-III.
What are the subcellular locations of this protein?
Secreted.
Protein: RS6_ALTMD
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTTILKQDGGQVHRLEDWGRRQLAYPIEKLHKAHYVLINAEATAEAVDELENAFRFNDVILRNMVMRTKTAVTEPSPMMKEEPRRERRDDSAPRQERAEKKTETTEDNA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: GLGC_ACIAC
Sequence: MSSTKNVLAIVMAGGEGSRLHPLTAERCKPAVPFNGKHRIVDFVLSNLVNSEIYSIYLLVQYKSQSLIEHIRQSWTMTRFIPQHFVTVVPPQMRNGPEWFQGTADSVYQNIHLIESFKPDIVAVFGADHIYRMDVRQMIDFHVKNDAHVSVATLPVKLADCNQFGIVETDDNHRIVDFVEKPQTPPRPMPGSSTHALASMGNYLFNADILLDALREAHETGHSDFGKHILPAMLKSHRLMAYDFDTNTIPGTEPYEEHGYWRDVGTIDAYYQAHFDTLGATPRFRMTNRHWPIYASPDQAESAQIENGVIHRSVVGSGSIVDGASLDNAMLRRSVVVERDARLEHCIVMERSRIGRGAQVRRAIIDQDNDIPAHERIGFDLEADRKRFHVTASGIVVVPRQFFKPQSLQSTTPSIGRARPSVASASEGSGLKVAA
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: C5133_DICDI
Sequence: MTSLTLYLIIFSIILYLFVNRNKRKNLKIPGPNGIPIFGNLLSLSGEMHLTLQEWYKTYGSVFSIRMGNIDTVVLTEYPTIRKAFVDNSLAFASRYQLKSRVVLTGAKDLAIQNGEIHSLLKKVVLSEMTTTKIKRMEIHIIKETEKILKILDKHAERGEPFIINNYLNMFSMNVILRFLLGIDYPYENVDETVGYVKSIKSFFAVAGLPILSDFIPIPLKKSGVFFDSYKELEIETDKLIEKFKKSRNEKIENGTYNEEEDESILSKLLKEYEHGNITWECVSHTCIDIISAGTDTSANTLVMALIELINNQEIQSKAFSSIRSSCLNDSNDDDDDDEIVITHSKYRSLLPYISMIIKETFRKHPIALLGLPHVTTEDVEIDGYKIEAGTYIIQNIFSSHRSDKIFQSPNEFIPERFFESSQNQGLIHFGLGVRDCVGKSLAECEIFTLIATLLNRYQFINPNNSKKLNDIGTFGLAQVCPDTNIILKKRI
What are the official names of this protein?
Probable cytochrome P450 513A3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS20_SACD2
Sequence: MANSPQAKKRARQNDKARAHNASLRSMVRTYLKKVVAAIEAGDAETAKAAYAVAIPVLDRVADKGIIHKNKAARHKSRLNAKIKALSA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: SYR_DESAP
Sequence: MSYLLAGLRAGIERALRGAVEAARPDLGLDSGTAIPPFTVEVPREKNHGDFATNLALLLTKPARRSPRQIAEILVSHLSLPELLVKEVTVAGPGFINFRLDPNWLHGVLPEIETWGEHYGRRNLGGGRKVQVEFVSANPTGLLHMGNARGAALGDSIAALLSFVGFDVTREFYVNDAGHQVENLALSMEARYFQALGRDWPVPEDGYHGEDLIDTAGRFVAEHGDRFASGDPDERRGALLRFALEEKLAAMRATLESFGVRYDVWFSEQSLYDRGVVGETLELLKKRGHLYERDGALWFKAGAFGGDKDEVLVRRNGVPTYFAADIAYHKDKYDRGFDWVINVWGADHHGHVPRMKGALAALGYDPDALDVVIMQLVRLYRGGEIVRMSKRTGRYVTLDELLEEVGRDAARYFFVTRGADSHLDFDLDLAKSRTNENPVYYIQYAHARISSIFRQLEERGRTAPGYRKIPDVTLLKEEAERALIRRLADFPDEVAQAAYDLAPHRIAHYVHDLAGLFHHFYNAHRVLGAGDGLEEARLMLVNCTRVVLRNALTLLGVSAPERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y521_BORPE
Sequence: MSGYFVLKASGTQYMFNLHAGNHEIILTSERYTSKASAQDGIASVQKNAPDDARYQRLTAKDGSPYFSLTATNGQSIGRSEMYKTTQARDNGIASVKSNAPGAPTKDQTQA
What are the official names of this protein?
UPF0339 protein BP0521.
What is the protein family that this protein belongs to?
Belongs to the UPF0339 family. Duplicated subfamily.
Protein: RK22_PSINU
Sequence: MEKKKEVRALAKYVKMSAHKVRRVINQIRGRSYEEALISLEFLPYRACYPLLQLVSSAAANANNNLGLKKDTLLISEAKVDEASVSKRFQPRAQGRAYSIQKDTCHITIKIRERSK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MUTS2_LISMC
Sequence: MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATDFQVVQKTQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEIGGDLNGLEIYQIGSNLRVSRQMKNFMNDLLEIGVELPLLGALSDELLVLKEVEEDIAISVDESGKVLDTASEALSTIRRTLRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKALQAKEKQEIERILAEISASLAAWINEIHHNTFILGRFDFIFAKARFGKAMKAVTPHLSDAGVVHLIAARHPLLDAAKVVANDIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIVSILGNVNQKSLILYDELGAGTDPQEGAALAIAILDASHAKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYKLLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGADNLLKDLQKEISNYYQQKDKLIEQASEKAATIVEKAEAEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGNAKPKTINKTIPQAPKQKPHVFQEGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTTDLEYIQPEKPKKQRIITSVHSSGSPAKSELDLRGERYEDALQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: STK4_BOVIN
Sequence: METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDSFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQEEEENSEEDELDSGTMVRAAGDEMGTVRVASSMSDGANTMIEHDDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPARPSFLEYFEQKEKENQINSFGKSVPGPLQNSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.  Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.  Phosphorylates MOBKL1A, MOBKL1B and RASSF2.  Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).  Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.  Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage.  Acts as an inhibitor of PKB/AKT1.  Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
What are the official names of this protein?
Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between nucleus and cytoplasm.
Protein: PIMT_ECO8A
Sequence: MVSRRVQALLDQLRAQGIQDEQVLNALAAVPREKFVDEAFEQKAWDNIALPIGQGQTISQPYMVARMTELLELTPQSRVLEIGTGSGYQTAILAHLVQHVCSVERIKGLQWQARRRLKNLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPPEIPTALMTQLDEGGILVLPVGEEHQYLKRVRRRGGEFIIDTVEAVRFVPLVKGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AS3MT_HUMAN
Sequence: MAALRDAEIQKDVQTYYGQVLKRSADLQTNGCVTTARPVPKHIREALQNVHEEVALRYYGCGLVIPEHLENCWILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTKGQVEVAEKYLDYHMEKYGFQASNVTFIHGYIEKLGEAGIKNESHDIVVSNCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGGALYWKELAVLAQKIGFCPPRLVTANLITIQNKELERVIGDCRFVSATFRLFKHSKTGPTKRCQVIYNGGITGHEKELMFDANFTFKEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKLAEESDSMKSRCVPDAAGGCCGTKKSC
What is the function of this protein?
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655).  It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655).  Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655).
What are the official names of this protein?
Arsenite methyltransferase, Methylarsonite methyltransferase, S-adenosyl-L-methionine:arsenic(III) methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: END4_GLAP5
Sequence: MKYIGAHVSASGGVENAVLRSVEIGANAFALFTKNQRQWQAPPLKEDTIEKFKRFCQVHHFSPAQILPHDSYLINLGNPEAENLAKSREAFIDEMRRCDQLGLTLLNFHPGSHLNKISEQDCLARIAESINIAVDSVPNVVAVIENTAGQGSNLGWRFEHLAEIIEQVENKQRVGVCLDTCHLFSAGYDISSLASCEQTFADFDKVVGFEFLRGMHLNGSKTLLASRVDRHHTLREGTIGTDVFKFIMNNAHFDNIPLILETIEPEIWAEEINFLRSLEQN
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: SFGH2_ECODH
Sequence: MEMLEEHRCFEGWQQRWRHDSSTLNCPMTFSIFLPPPRDHTPPPVLYWLSGLTCNDENFTTKAGAQRVAAELGIVLVMPDTSPRGEKVANDDGYDLGQGAGFYLNATQPPWATHYRMYDYLRDELPALVQSQFNVSDRCAISGHSMGGHGALIMALKNPGKYTSVSAFAPIVNPCSVPWGIKAFSSYLGEDKNAWLEWDSCALMYASNAQDAIPTLIDQGDNDQFLADQLQPAVLAEAARQKAWPMTLRIQPGYDHSYYFIASFIEDHLRFHAQYLLK
What is the function of this protein?
Serine hydrolase involved in the detoxification of formaldehyde.  Hydrolyzes S-formylglutathione to glutathione and formate (By similarity).
What are the official names of this protein?
S-formylglutathione hydrolase YeiG, FGH.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.