PharMolix/UniProtQA huggingface dataset:
Protein: THIC_SYNPW
Sequence: MRASWVESRRGQANVSQMHFARQGVVTEEMAYVAKRENLPESLVMEEVARGRMIIPANINHTGLEPMAIGIASKCKVNANIGASPNASDAAEEVNKLKLAVKYGADTVMDLSTGGVNLDEVRTAIIDASPVPIGTVPVYQALESVHGSIEKLDEDDFLHIIEKHCQQGVDYQTIHAGLLIEHLPKVKGRLTGIVSRGGGILAQWMLYHHRQNPLFTRFDDICEIFKRYDCTFSLGDSLRPGCQHDASDAAQLAELKTLGELTRRAWAHDVQVMVEGPGHVPLDQIEFNVKKQMEECSEAPFYVLGPLVTDIAPGYDHITSAIGAAMAGWHGTAMLCYVTPKEHLGLPNAEDVREGLIAYKIAAHAADIARHRPGARDRDDELSRARYNFDWNKQFELSLDPERAKEYHDETLPADIYKQAEFCSMCGPKHCPMQTKITDEDLEGLEKVLETKSGAADLAGVKMEKES
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: PVK1_APTFU
Sequence: GSSGLIPFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, AptFu-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL22_RICAE
Sequence: MVQENKNFATAQAKSIRVSSRKLNLVAAFIRNMKVSEALVQLTFSPKRIAKVVKDCLQSAVANAENNLGLDIDRLVITKATVGKALVMKRVMPRAKGRATRINKFFSNLYITVTEKEDN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RPAP2_RAT
Sequence: MADSAVPYSLGPSARASSTHRVATGTKQTSALKRRDASKRQAELEAALQRKVESERRAVRLVEQLLEENITEEFLKECGMFITPAHYSDVVDERAIIKLCGYPLCQKKLGVIPKQKYRISTKTNKVYDITERKSFCSNFCYKASKFFEAQIPKTPVWVREEERPPEFQLLKKGQSGCSGEVVQFFRDAVTAADVDAYGAFDAQCEPASSSTWSERASDERASDEEGPGFVSSLLPGNRPKAVGTKPQPHRQSSTVKKKAAQKMTSKHGEQTVSEVTEQLSNCRLDSQEKVATCKLPAKKENTQISSPGPLCDRLNTSTVSENKHSVSQVTLVGISKKSAEHFRSKFAKSNPGSGSASGLVQVRPEVAKANLLRVLKDTLTEWKTDETLKFLYGQDHGSVCLQPSAASGPDEELDEDDISCQAQNTLDETLPFRGSDTAIKPLPSYESLKKETEMLNLRVREFYRGRCVLNEDSTKSQDSKENELQRDPSFPLIDSSSQNQIRRRIVLEKLSKVLPGLLGPLQITMGDIYTELKNLVQTFRLSNRNIIHKPVEWTLIAVVLLSLLTPILGIQKHSPKNVVFTQFIATLLTELHLKCEDLENLAMIFRTSC
What is the function of this protein?
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes.  Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).  Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity).
What are the official names of this protein?
RNA polymerase II subunit B1 CTD phosphatase Rpap2, Putative RNA polymerase II-associated protein 2.
What is the protein family that this protein belongs to?
Belongs to the RPAP2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.
Protein: SYS_METLZ
Sequence: MLDIKFVRAHPEVVLADLEKRQDAEKLLWVDTVLEQDKLFRELTVKNNELRARRNQIAKEINAYKKEGKDPAPLFAEAKALPGLIKDNDDIMEKATEQVRYYLMRLPNILHESVPYGKDDTENVVVKKVGTPRSLDFELKNHGELAAANGWADFERATKTSGAGFYFLKGNLALLDMALQRFALDTIIAKGYTPIIPPYMMNRKSYEEVTDLGDFEKVMYKIEDDDAYLIATAEHPMAAMYQDEIFEEKDLPLKMVGISPCFRREIGAHGLDSRGLFRVHQFTKIEQFIYCMPEKSWEMHEELLANAEEIFTKLGLPYRVVNICTGDIGTVAAKKYDMEAWMPRDNEYREVVSCSNCTAYQSVRLNIRVRDAHDFESKQWLHTLNSTAVATSRALRCILENYQTEDGKVEIPKVLRPYMNGLEYL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHOG_DROYA
Sequence: MTLLTSSLLFFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPSHPSPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSSGAGFKYLRTGTAKANVSQEAAISRLKVLVRQDTLGEYRCVGWFGPLVVTSTIARLELASTSLLGGQESESPLQWRVSAGNSVLWPCGKQVKSNPSASWSYYRNGVEIKPEFIGTNGNIFLSNVSSESSGSYSCQATNPASGERIQLTGSLQLQVTPEQRSQSKSPHLLNGQPNSQEITIREGSSLLLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVIGHALEISNTRVQDAGTYICFQDNGVRPVLEHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECEATGVPTPEIYWLLNGHSSLDDTEAELSNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSKQKQMYPPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWSLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAVSASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVLILLLISTCLCVCRRRSSRSRGNNPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHITLNPLAQQQQQALEEKNDTDQDAPYYQRPSSYDYDPGLRRMSSSSLRRSQRTLERAGGSNGSNNGNNNNLNQSAEAGPVENPGKPGRVLMKRPRLSSRSENLSSGSLNSVGV
What is the function of this protein?
Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).
What are the official names of this protein?
Interference hedgehog.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. IHOG family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TYSY_BARBK
Sequence: MKAYLDLLSHVLNNGTDRSDRTGVGTRSVFGYQMRFNLQEGFPLLTTKKLHLRSIIYELLWFLKGDTNIAWLKEHGVSIWDEWADKDGNLGPVYGYQWRSWPSSDGRYIDQISNLLAMINHNPNSRRLIVTAWNPALIDEMALPPCHCLFQFQVANGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKVGDFIHTLGDAHLYSNHFEQAKQQLSRTPGILPLIRINPKVTDLFSFQFEDFELLNYEAQPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_STAAT
Sequence: MRILVEIAYQGNNFLGFQIQQNGRTVQQQFEKLLQRMHKRHVRIHPSSRTDRGVHAIQQYFHFDTELNIPMSQWQYAMNRTLPDDIYVNNVVTVDDDFHCRYDCVGKRYRYKVYQAQHRDPFQSGLKTFIPETLDLGKMNRAAQQFIGTHDFTGFCSQKTEVESKVRTLYQSEIVKTDDGFDYIVTGSGFLYNMVRVLVAFLIEVGKGRHEVSDVPKLLESKNRKNVPFTAPAEGLYLEKIYLDENELLKDFGNDIKIHRKKSLQND
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: ISPD_ECO55
Sequence: MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: NRTA_SYNY3
Sequence: MSNFSRSTRRKFMFTAGAAAIGGVVLHGCTSPTTTSTGTGTGSSTDQAISPLVEGENAPEVTTAKLGFIALTDAAPLIIAKEKGFYAKYGMPDVEVLKQASWGTTRDNLVLGSASGGIDGAHILTPMPYLITMGTVTDGKPTPMYILARLNVNGQGIQLGNNYKDLKVGTDAAPLKEAFAKVTDPKVAMTFPGGTHDMWIRYWLAAGGMEPGKDFSTIVVPPAQMVANVKVNAMESFCVGEPWPLQTVNQGVGYQALTTGQLWKDHPEKAFGMRADWVDQNPKAAKALLMAVMEAQQWCDQAENKEEMCQILSKREWFKVPFEDIIDRSKGIYNFGNGQETFEDQEIMQKYWVDNASYPYKSHDQWFLTENIRWGYLPASTDTKAIVDKVNREDLWREAAQALEVPADQIPSSPSRGIETFFDGITFDPENPQAYLDSLKIKSIKA
What is the function of this protein?
Part of the ABC transporter complex NrtABCD involved in nitrate uptake (PubMed:16777960).  The complex is probably also involved in nitrite transport (By similarity).  NrtA is the substrate-binding protein (PubMed:16777960).  Binds nitrate (PubMed:16777960).
What are the official names of this protein?
Nitrate/nitrite binding protein NrtA.
What is the protein family that this protein belongs to?
Belongs to the CmpA/NrtA family.
What are the subcellular locations of this protein?
Cell inner membrane; Lipid-anchor; Periplasmic side.
Protein: HIS1_XANOR
Sequence: MSASTAAPARDRLRIAIQKSGRLAEPARSLLAACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIADGVCDLGIVGQNELEEQAAERRGNGLPAAYHAVRGVGFGQCRLMLAVPEEWDWQGVAQLAGKRIATSYPAILADWLERQGIEATVVELSGSVEIAPRLGTADLICDLVSSGATLAANQLKPVELVMESEAVLAGAVREPADARAGLLAMLLRRMDGVLKLRDSKLLMFRADQDNVDALRRLLPDADPLVQLPDDGNGVLRLQTMCHGAVTWQRLEELERAGAQGLMVLTVERSLA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_THEMA
Sequence: MRRLNRKNNEALKKLNDRQRKVLYCIVREYIENKKPVSSQRVLEVSNIEFSSATIRNDMKKLEYLGYIYQPHTSAGRIPTDKGLRFYYEEMLKISKETSEADLAVETFKSMPLADPEKVLFLAGNLLARLTEGYVLIERPNTRDLKILRVMLIPVSEDYLIFSILTEFGVSKVTPIKTQERLNWEEIERQLNFLLRGRTVGEVLMGKIESLKGSGFLRLIESLIGETVERYLDAGLENLLKDETLTLEDIRNLLEEVKDQKFLESLVGEGITVRIGREIGRKKLEKFAVFSGKYFKGESPIGSVYLFTSKVTKYDRNHRVFEYILNRLSEYFTSTSRR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: HSLV_VIBC1
Sequence: MTTIVSVRRNNKVVIAGDGQVSLGNTVMKGNARKVRRLYNNQVLAGFAGGTADAFTLFERFESKLQMHQGHLTKAAVELAKDWRSDRALRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGAYAQAAATALLENTDLDAREIAEKALNIAGDICVFTNHHHTVEELESTVELPKPTA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP1BA_MOUSE
Sequence: MALLILLFLLPSPLHSQHTCSISKVTSLLEVNCENKKLTALPADLPADTGILHLGENQLGTFSTASLVHFTHLTYLYLDRCELTSLQTNGKLIKLENLDLSHNNLKSLPSLGWALPALTTLDVSFNKLGSLSPGVLDGLSQLQELYLQNNDLKSLPPGLLLPTTKLKKLNLANNKLRELPSGLLDGLEDLDTLYLQRNWLRTIPKGFFGTLLLPFVFLHANSWYCDCEILYFRHWLQENANNVYLWKQGVDVKDTTPNVASVRCANLDNAPVYSYPGKGCPTSSGDTDYDDYDDIPDVPATRTEVKFSTNTKVHTTHWSLLAAAPSTSQDSQMISLPPTHKPTKKQSTFIHTQSPGFTTLPETMESNPTFYSLKLNTVLIPSPTTLEPTSTQATPEPNIQPMLTTSTLTTPEHSTTPVPTTTILTTPEHSTIPVPTTAILTTPKPSTIPVPTTATLTTLEPSTTPVPTTATLTTPEPSTTLVPTTATLTTPEHSTTPVPTTATLTTPEHSTTPVPTTATLTTPEPSTTLTNLVSTISPVLTTTLTTPESTPIETILEQFFTTELTLLPTLESTTTIIPEQNSFLNLPEVALVSSDTSESSPFLNSDFCCFLPLGFYVLGLLWLLFASVVLILLLTWTWHVTPHSLDMEQSAALATSTHTTSLEVQRARQVTMPRAWLLFLQGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLGTVGIRYSGHSL
What is the function of this protein?
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
What are the official names of this protein?
Platelet glycoprotein Ib alpha chain, GP-Ib alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL2_DICT6
Sequence: MGLKKFKPITPGLRHLILPDFSEITKEEPEKSLLKPLKKSGGRNNFGHVTSRFRGGGHKRLYRIIDFRRDKDNIPAKVASIEYDPNRTARIALLHYADGEKRYIIAPEGLKVGDIIMSGENVDIKIGNNLPLKNIPDGTLIHNLELYPGRGGQLVRAAGTAAQILGKEGKWAYVRLPSGEIRLFDLNCRATIGQVSNVDHQNVSLGKAGRSRWLGRRPHVRGSAMNPVDHPHGGGEGKAPIGHPSPLTPWGKPTLGYKTRKKRKPSDRFIIQRANDKKEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: 5HT7R_CAVPO
Sequence: MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.  The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
What are the official names of this protein?
5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, 5-HT-X, Serotonin receptor 7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ORF3_HEVPA
Sequence: MGSRPCALGLFCCCSSCFCLCCPRHRPVSRLAAVVGGAAAVPAVVSGVTGLILSPSQSPIFIQPTPSPPMSPLRPGLDLVFANPPDHSAPLGVTRPSAPPLPHVVDLPQLGPRR
What is the function of this protein?
Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity.  Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway.  Acts also as a viroporin and forms ion conductive pores allowing viral particle release.  Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways.  Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression.  Interacts with host microtubules.
What are the official names of this protein?
Protein ORF3, pORF3.
What is the protein family that this protein belongs to?
Belongs to the hepevirus ORF3 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane. Host cytoplasm. Note=The N-terminal region seems to associate with the cytoskeleton probably via one of its hydrophobic regions.
Protein: SYG_PYRHO
Sequence: MNGKFDKYEYLQDLMRRRGFAWGSFEIYGGSRGFYDYGPLGATIKRKIERKIREAFIREGFFEIETPDITPEQVFIASGHVEKFVDPVVECKKCGMRFRADHLIEEFLGIDVEGKSAEEMSRIIREHGLKCPECGGELSDVFYFNLMFETYIGPYKDKKAYLRPETAQGIFVNFKRLNAFARNKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEAEIFFNPNETEHPHFNEVKHEKLKLYPIENQLKELGEVEVTAEEAVKRGYVMNSFFAYYMVMIKKILLDIGIPEDKIRFRQQLPEERAHYSADTWDAEVYSERFGWVECVGLAYRTDYDLSRHMKMSGADLTVMIHYDKPKVVKRIQVSLNMKKVGPKLKADAKKINEIIKSMDQKELEKLVKDLNEKGKVTIEGYELSKEDFIVKEVEEKITGEKIVPHVLEPSFGIDRPFYLLLENSLTVDEDGRIYLKIKKDMAPIEVAVLPLVAKEPLTTIAYEIYRTLQKEGFIVVYDEKDSIGKRYMRYDEIGTPYCVTVDNQTPEDGTVTIRDRDTREQIRVKIEELPRKLKELIFG
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP5_ROTH3
Sequence: MSLSIDVTSLPSISSSIYKNESSSTTSTLSGKSIGRSEQYISPDAEAFSKYMLSKSPEDIGPSDSASNDPLTSFSIRSNAVKTNADAGVSMDSLTQSRPSSNVGCDQVDFSLNKGIKVSANLDSSVSISTNVKKEKSKNDHRSRKHYPKIEAESDSDDYVLDDSDSDDGKCKNCKYKRKYFALRMRMKQVAMQLIEDL
What is the function of this protein?
Plays an essential role in the viral genome replication.  Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories.
What are the official names of this protein?
Non-structural protein 5, NSP5, NS26.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP5 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: ATPF2_PROMA
Sequence: MTSLLLFGASEGGLFDFDATLPLMAAQVVLLTFILNALFFKPVGRVVEDREDYVLTSRAEAKKKLAEVEKLENDLKNQLKEARKAAQQVISEAEEDSEKLYKEALNLANSEANASREQARREIDSQRDSALKKLKSDSDKLGDLIVERLLAAK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
What are the official names of this protein?
ATP synthase subunit b', ATP synthase F(0) sector subunit b', ATPase subunit II, F-type ATPase subunit b', F-ATPase subunit b'.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: 3HAO_CANAL
Sequence: MVLGQPINIIKWIEENGDLLKPPVNNFCLHRGGFTIMIVGGPNERSDYHINQTPEYFYQFKGTMCLKVVDDGEFKDIFINEGDSFLLPPNVPHNPCRYENTIGIVVEQDRPAGVNDKVRWYCQKCQTVIHEVEFYLTDLGTQIKEAIVKFDADLDARTCKNCGTVNSSRRD
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD, Biosynthesis of nicotinic acid protein 1.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KVD17_HUMAN
Sequence: MDMRVPAQLLGLLLLWFPGARCNIQMTQSPSAMSASVGDRVTITCRARQGISNYLAWFQQKPGKVPKHLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 1D-17.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: MRAZ_SOLM1
Sequence: MFRGHSNRSLDPKGRLMLPPEFREEIFRLVPDGRVMLTNNFDGAISGYPMPEWEAVEASFRAGNTLMPGFRDIERFFIAGATEVTVDKQGRILIPPYLRTYAGLDKEMVLAGVGTKFEIWDQGRFEERLRQTAANFNAHMEAMAASGVSLRF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RS12_SULNB
Sequence: MPTINQLIRKERKKQVKKSKSPALVKCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTSGFEVISYIGGEGHNLQEHSIVLVRGGRIKDLPGVKYHIVRGALDASGVTGRTVARSKYGTKKPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: CLPP_BLOPB
Sequence: MQCSHNFKTPYCHRMVVVPTVIEHTIRGDRVYDIFSLLLKERIIFMTGTIEDSVANLIVAQMMFLESENSEKDIHLYINSPGGVITAGMSIYDTIQFVRPDVSTFCMGQAASMSAFLLASGTKGKRFCLPNARIMIHQPLGSFQGQATDIAIHTREILKIKNNINKLMAKHTGQSIDIINKDTERDCFLSADEAMKYGLVDCVLSQRI
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_RHIME
Sequence: MNREQSGKTLVLIPARMASTRLPGKPLADICGLPMIVQVARRAAEAEVGRIVVAVDHPDVFAAVTGAGFEAIMTRVDHQSGSDRIHEALLKADPHGEAEIVINVQGDLPTIEPGPIRAALKPLENPATDIATLTVAITDEHEKTNPNVVKVVGSPLSDSRFRALYFTRATAPYGEGPLYHHIGLYAYRRKALETFVSLKPSTLEKRESLEQLRALEAGMRIDVEVVDSVPLGVDTPADLDKARRILSARV
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.