PharMolix/UniProtQA huggingface dataset:
Protein: SYS_BURMA
Sequence: MLDIQLLRKDLDGVAKRLADRGYPLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGDEMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETENVEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGARFTVLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISLTNTVRDSIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASYAALDEMVGHAEAILQKLELPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPVALRPYMGGVERIDAPSSAA
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CXA4_RAT
Sequence: MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAFPISHIRYWVLQFLFVSTPTLIYLGHVIYLSRREERLRQKEGELRALPSKDPHVERALAAIEHQMAKISVAEDGRLRIRGALMGTYVISVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPHVVDCYVSRPTEKTIFIIFMLVVGVISLVLNLLELVHLLCRCVSREIKARRDHDTRPAQGSASDPYPEQVFFYLPMGEGPSSPPCPTYNGLSSTEQNWANLTTEERLTSTRPPPFVNAAPQGGQKSSSRPNSSASKKQYV
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction alpha-4 protein, Connexin-37, Cx37.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: HBAD_SPHPU
Sequence: VLTHEDCELLQQTWEKVLGHQEDFGAEALERMFITYPQTKTYFPHFDLHHGSEQIRNHGRKVVNALGEAVKNMDHMSTASGELSNLHAYNLRVDPVNFKLLSECFEVVLAVHLKDQYTPDVHRAYDKFLSAVGDMLAEKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-D, Alpha-D-globin, Hemoglobin alpha-D chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ILVC_BACLD
Sequence: MVKVYYNGDIKENVLAGKKVAVIGYGSQGHAHALNLKESGVDVIVGVRKGKSFAKAEEDGHQVFTVREAAEQADIVMVLLPDEQQQKVYEAEIKDGLQAGNSLVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTFEQGAGVPALFAIYQDVTGEAKDKALAYAKAIGGARAGVLETTFKEETETDLFGEQAVLCGGLTSLVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDEKVKESMKEVLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKEAVVAGAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: HIS61_VIBVY
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVARVAEVIDIPFCVAGGIKSAEDAARILEFGADKVSINSPALANPQLITDLADKFGVQCIVVGIDSYYDKETGKYQVYQFTGDEERTKATQWETRDWVQEVQKRGAGEIVLNMMNQDGVRNGYDIEQLNMVREVCNVPLIASGGAGAMEHFAEAYQKANVDGALAASVFHKQVINIGELKQYLKQQGIEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit hisF1, IGP synthase cyclase subunit, IGP synthase subunit hisF1, ImGP synthase subunit hisF1, IGPS subunit hisF1.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EWG_DROME
Sequence: MATTSYRLVVAPAGSQRSSTGNVVVTTTSSGSHSSNGANGGTGGTSAGSSTLGSGLNVTTITATSGGQLQSAGNTSQSNGTTYKIEMLEEDIQSLGSDDDDEDLISSDGSLYEGDLGSMPVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRAIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMELSNPPTIHTVTTMTPPTGNSNQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAQNQQHHQHHQTHLPNAVHIQPVAGGQPQTIQLTTASGTATATAVQTTAAAVSAAQAHAHSQSQAHSQSSANQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTETQDGQIYITTEDGQGYPVSVSNVISVPVSMYQSVMANVQQIQTNSDGTVCLAPMQVENGDQLETITMSPGMHQMMIQGGPGQEPQLVQVVSLKDATLLSKAMEAINSGNVKSEDTIIMEQ
What is the function of this protein?
May function as a positive regulator of transcription in developing and differentiated neurons, regulating common aspects of neuronal differentiation and maintenance.  Requirement in the CNS may be higher than in the peripheral system.  Vital for development of the indirect flight muscles.
What are the official names of this protein?
DNA-binding protein Ewg, Protein erect wing.
What is the protein family that this protein belongs to?
Belongs to the NRF1/Ewg family.
What are the subcellular locations of this protein?
Nucleus. Note=Not in nucleolus.
Protein: AROE_SHEB8
Sequence: MTDRYAVFGNPISHSKSPFIHGQFAAPTQESLTYEAILAPVDGFEASLTAFFNAGGKGANVTVPFKEQAFALCDSISPEAKLAGAVNTLSLLADGTIRGDNTDGLGLVADLIANLGSLQDQRVLLIGAGGAARGCILPLLNAGIAQLTISNRTHTKAQLLVDIFTSVDNGAYVSKVTAVEMSELAGEFDIIINSTSASLAGELPPLPAHIITTQTVCYDMMYGASVTAFNQWALSQGAAKVIDGLGMLVGQAAKSFTLWRGIEPDTQVVLTLLRDKLMAEPK
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: ARMET_DROVI
Sequence: MNTSHIVLMICFIVGVGQTALALKEDDCEVCVKTVKRFADTLDDATKKDYKLIETAFKKYCKTQKNKEHRFCYYLGGLEESATGILNELSKPLSWSMPAEKVCEKLKKKDAQICDLRYEKQIDLNSVDLKKLKVRDLKKILNDWDESCDGCLEKSDFIKRIEELKPKYSRNEL
What is the function of this protein?
Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity.  Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity).
What are the official names of this protein?
Mesencephalic astrocyte-derived neurotrophic factor homolog, MANF/CDNF-like protein.
What is the protein family that this protein belongs to?
Belongs to the ARMET family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM_HALH5
Sequence: MSKEQKTFYLTTPIYYPSDKLHIGHAYTTVAGDAMARYKRLRGYNVMYLTGTDEHGQKIEQKAEAKGLTPKQFVDEIVSGIQDLWKKLDISYDDFIRTTEERHIKVVQQIFEQLLDQGDIYLGDYEGWYSIPDETFYTETQLVDKEYDADGNLIGGKSPDSGHPVEKVREQSYFFRMSKYADRLLQFYEENPQFIQPESRKNEMINNFIKPGLEDLAVSRTSFTWGVPVPRDPKHVVYVWIDALSNYITALGYGSDQQEKYENYWPADVHLVGKEIVRFHTIYWPIMLMALDLPLPKKVFGHGWLLMKDGKMSKSKGNVVDPVPLIDRYGLDALRYYLLREVPFGSDGVFTPEAFVERVNYDLANDLGNLLNRTVAMIEKYFDGKIPSYVKDGTPFDADLVELVYSTVKKVEDAMEEMEFSIALTAIGQLISRTNKYIDETQPWVLAKDESKREQLGAAMYHLAESIRYVSVLLQPFMTKAPQKIWEQLGIDSSLTTWESLETFGQIPGNTNVQKGQPLFPRLDVEEEVAHIKSLMGGSKKPEEAPKDEKEESDEITIDDFSKVELRIAEVIDAEPVKKADRLLKIQLDLGYEKRQVVSGIAKYYSPSDLIGKKVICVTNLKPVKLRGELSQGMILAGSEGDQLRLATVDGALPNGSLVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
Protein: YOE2_STRAT
Sequence: MRTRITLALAVLLLLLAGCSPGAPADGPVTLRFQSLAWQPDSVAATKELVGEWNATHPDVKVEYIQGSWDSVHDQLLTSFEGGEAPDVIHDASDDLADFAYGGYLADLSGLLPARLASDIPRGSWETATFGRGVYGVPFLQEPRVLIADADRLRAAKVRIPTPGHPWSWPEFRQVAKKLTGPGRYGVAWPLKEPVSATLNLSLSAGGRLFHRGADDKVTVRFEAGDEVVARTIHDQVAVDREHAPASTLGSGGADTLPGLFGGRYAMVPLGFSYRQQIVRQAPEDFHWQVLPAPAGAGGLTQGVSPQTLSVSADCPHKKEAVAFIDFLLRPRNMVRLALGDWMLPTGTQALKDPALHTARHGWATGTALAARLRPAPAQSVRGYPEWKDKVATPAYQRYYSGASTLADVRHAWSGTATWCWPATSADPPPGVPRAGKRNIRDATSRLPSTP
What is the function of this protein?
May participate in oleandomycin glycosylation and secretion during antibiotic production.
What are the official names of this protein?
Uncharacterized lipoprotein in oleD 5'region, ORF2.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GLMU_STRA1
Sequence: MSNYAIILAAGKGTRMKSDLPKVMHKVSGITMLEHVFRSVQAIEPSKIVTVIGHKAELVRDVLGDKSEFVMQTEQLGTGHAVMMAEEELATSKGHTLVIAGDTPLITGESLKNLIDFHVNHKNVATILTADAANPFGYGRIIRNSDDEVTKIVEQKDANDFEQQVKEINTGTYVFDNQSLFEALKDINTNNAQGEYYLTDVIGIFKEAGKKVGAYKLRDFDESLGVNDRVALATAEKVMRHRIARQHMVNGVTVVNPDSAYIDIDVEIGEESVIEPNVTLKGQTKIGKGTLLTNGSYLVDAQVGNDVTITNSMVEESIISDGVTVGPYAHIRPGTSLAKGVHIGNFVEVKGSQIGENTKAGHLTYIGNAEVGCDVNFGAGTITVNYDGQNKFKTEIGSNVFIGSNSTLIAPLEIGDNALTAAGSTITDNVPIDSIAIGRGRQVNKEGYANKKPHHPSQK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_SHESM
Sequence: MSITKDQILEAFAAMSVMEVVELIEAMEEKFGVSAAAAVVAGGAADAGAAAEEQTEFNVILTAHGDNKVAVIKAIRGATGLGLKEAKAMSEAAPVAVKEGVSKEEAEALKKELVEAGATVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: GPA10_CAEBR
Sequence: MGACGSVMQDEALKEQARIHRQIEKSLEKKKSALLEQSVLLIGPGESGKSTVLKQIRSVTVCRAMCGGYTKHELEEKKLLILRNLWTFSDMLLEYVIKNYLDMNETDKKKYKVMIEELKFCVMSGGHMGDELAETVKVFWLCAPIQEAYEKRNTYHLTESAGYFFENIDRIKMPDFQPTNQDIVRIRVPTTGVVTADVILKNIKLSVIDCGGQRQERRKWYHYFDDVHAVLFVAAISEYDQKLVEDESVNRMDEALNLYHIVFNGKYFTKAACILFLNKIDLFREKVKSVSIKKFHPGFEGANTAEDGAKYFRRKFRDGMHPDFKKRLYCHETCAISDQVQIIINTVIDTVVQENLKDTGMI
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-10 subunit.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: MTND_YERPG
Sequence: MSGLTIFSDQQPEKPLWQSHNAEEIQQQLTAIGVRFERWQADCELGENPQPEAVIAAYQHEIDRLVAENGYKSWDVISMRPDNPQREALREKFLSEHTHGEDEVRFFVEGSGLFCLHLNEKVYQILCEKNDLLSVPADIPHWFDMGSAPNFTAIRVFDNPEGWIARSTGDNIADGYPRLA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: RSD_SALDC
Sequence: MLNQLENLTERVGGSNKLVDRWLDVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLLHAAKIWPLLEDNTQRIMDYYDTSLETAIDHDNCLEFQQALSDIGEALEARFVLEDKLIMLVFDAMHDGARVKRPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_ANASK
Sequence: MRKEKSLGLAAEMRTLAEASREAARALSHADPRRKDAALRAAAEAIGRREKRILSENARDVAAARAAGQNAAYLDRLKLDPKRLAGIAAALHEIAGLRDPVGEVTASWRRPNGLEIRKVRIPLGVVLMVYEARPNVTVDAAALCLKSGNAAILRPGSDALRSSLALAAAFAEGLEKAGLPAASAQVVPTPDREATYELLALDDLIDLAIPRGGPSLIRAVAERSRVPVLKHYQGVCHLYLDASAPPQQAVDLALNGKVQRPGVCNATECLLVHRGAAGKLLPPVGRALADAGVELRCDPTALTILKRAGVAAVPARPDDFGKEFLDRILAVRVVADLDGALDHIARYGSLHTEAIVTRDLASARRFQREVDASAVMVNASTRFNDGGELGLGAEIGISTTKLHAFGPMGLAELTTQKFLVEGEGHVR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_SACD2
Sequence: MYKLTTRQQEVLDLIKSHIEDTGYPPTRAEIANQLGFRSANAAEEHLKALARKGAIEMVPGASRGIRLPETIQGIPLIGRVAAGNPILAEQNIEDYCDVPPDFFYPQANYLLKVQGMSMRDAGILDGDLLAVHSTTQVKNGDIVVARIEDEVTVKRFKRERNNATIQLLPENPDFNIIEVDLRDANFSIEGLSVGIIRREL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: SODL_RABPU
Sequence: MAVCIIDHDNIRGVIYFEPVHGKDKVLGSVIGLKSGTYSLIIHRYGDISQGCDSIGSPEIFIGNIFVNRYGVAYVYLDTDVNISTIIGKALSISKNDQRLACGVIGISYINEKIIHFLTINENGV
What is the function of this protein?
Virion protein with no enzymatic activity.
What are the official names of this protein?
Cu-Zn superoxide dismutase-like protein.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: ENO_TRIL1
Sequence: MSEIVDIYAREILDSRGNPTLECEVFLESGAFGRAAVPSGASTGEREALELRDGDKGRYLGKGVLQAVDNVNNRIADELIGMEASDQVGIDQRMLEMDGTEFKSNLGANAILGVSLAVAKAAAEEAGLPLYKYIGGANARELPLPMMNIINGGAHADNNVDIQEFMIMPAGACCFAEALRMGAEIFHALKGVLKAKGYNTAVGDEGGFAPNLKSNEEALEVIMEAIVKAGYKPGDDVLLALDVASSELFDKEKGIYTLENEAQKEKTPAQMVDFYENLVNKYPIISIEDGMAENDWDGWKLMTDRLGKKIQIVGDDLFVTNPKILKEGIQKGIANSILIKLNQIGTLTETLEAIEMAKRAGYTTVISHRSGETEDTTLADLAVAVNAGQIKTGSLCRTDRVAKYNQLLRIEDELDTTAEFKGHNVFYNIKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: K2C1_MOUSE
Sequence: MSLQCSSRSLCRGGGGSRNFSSGSAGLVSFQRRSTSSSMRRSGGGGGGRFSGGGFCGSSGSGFGSKSLMNLGGGRSISKSVAGGGGSFCGGFGGGSYGGGGFGGGSYGGGGFGGGSFGGGGFGGSGFGGGLGGGGGFGSGGGFGGGRFGSMGPVCPPGGIQEVTINQSLLQPLNVEVDPQIQKVKSQEREQIKSLNDKFASFIDKVRFLEQQNQVLQTKWELLQQVDTTTRTQNLDPFFENYISILRRKVDSLKSDQSRMDSELKNMQDLVEEYRTKYEDEINKRTNAENEFVTIKKDVDSAYMTKVELQAKADALQQDIDFFSALYQMEMSQMQTQISETNVVLSMDNNRSLDLDGIISEVKAQYDSICQRSKAEAETFYQSKYEELQITAGKHGDSVRNTKMEISELNRMIQRLRSEIDGCKKQISQIQQNINDAEQRGEKALKDAQNKLNEIEDALSQCKEDLARLLRDFQELMNTKLALDMEIATYKKLLEGEEIRMSGECTPNVSVSVSTSHTSMSGSSSRGGGSGGGRYGGGGSYGGGSGGGSYGGSSGGGGSGGSYGGGSGGGSYGGGSGGGSSGSHRGGSGGGGGSSGGSYGGSSGGGRGGSSSGGGGVKSSGSSTVKFVSTSYSRGTK
What is the function of this protein?
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1).  In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity).
What are the official names of this protein?
Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, CK-1, Keratin-1, K1, Type-II keratin Kb1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm.
Protein: QUEC_SALEP
Sequence: MKRAVVVFSGGQDSTTCLAQARHQYDEVHCVTFDYGQRHRAEIDVARALALKLGARAHKVLDVTLLNELAVSSLTRDSIPVPDYEPNADGIPNTFVPGRNILFLTLAAIYAYQVKAEAVITGVCETDFSGYPDCRDEFVKALNHAVNLGMAKDIRFETPLMWIDKAETWALADYWGQLDLVREETLTCYNGIKGDGCGHCAACNLRANGLNHYLSNKAAVMAAMKQKTGLR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RECO_STRPB
Sequence: MQLTESLGIVLFNRNYREDDKLVKIFTEVAGKQMFFVKHISRSKMSSIIQPLTIADFIFKLNDTGLSYVVDYSNVNTYRYINNDIFRLAYASYVLALADAAIADNESDSHLFTFLKKTLDLMEEGLDYEILTNIFEIQILDRFGISLNFHECAICHRTDLPLDFSHRFSAVLCSEHYYKDNRRNHLDPNVIYLLSRFQKITFDDLRTISLNKDIKKKLRQFIDELYHDYVGIKLKSKTFIDNLVKWGDIMK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: LOC1_ASPNC
Sequence: MAPTKGSGSGKASNKGDAKKSKPLSSASKVNKKTAKRPPPKEVKSKARTESSLLKKTKKREYTEEELGLPKLNAITPVGVVKPKGKKKGKTFVDDAEGMMTILAMVNAEKEGQIESKMMKARQLEEIREAKRKEAEARQAQKKSKLEDAKQSIRQKRKHKGGSSETKAEAPTKESSSKSKGKKKSVAFA
What is the function of this protein?
Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
What are the official names of this protein?
60S ribosomal subunit assembly/export protein loc1.
What is the protein family that this protein belongs to?
Belongs to the LOC1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: EAE_CITFR
Sequence: MIIHGFCTGTRHKHKLRKTFIMLGAGLGLFFSVNQNSFANGENYFKLRADSKLINNNIAQDRLFYTLKTGESVAQLSKSQGISVPVIWSLNKHLYSSESEMMKASPGQQIILPLKKLSAEYSTLPILGTAPVVAAADVAGHTKKMSQDTTKSNTSDDKALNYAAQQAASLGSQLQSRSLNGDYAKDTALSMAGNQASSQMQAWLQHYGTAEVNLQSGNNFDGSSLDFLLPFYDTENMLAFGQVGARYIDSRFTANLGAGQRFFLPENMLGYNVFIDQDFSGNNTRLGIGGEYWRDYFKSSVNGYFRMSGWHESYNKKDYDERPANGFDIRFNGYLPSYPALGGKLMYEQYYGDNVALFNADKLYSNPGAVTVGVNYTPIPLVTMGIDYRHGTGNENDLLYSMQFHYQFDKPWSQQIEPQYVNELRTLSGSRYDLVQRNNNIILDYKKQDILSMNIPHNINGTEHSTHKIQLIVKSKYGLERIVWDDSTLRTQGGQIQHSERKAHNDYQAILPAYVQGGSNVYKVTRRAYDRNGNSSNNVQLTITVLSNGQVVDKVGITNFTADKTSAKADNSDTITYTATVKKNGVAQANVPVSFNIVSGTATLSAKSANTNSSGKATVTLKSDKPGQVVVSAKTAEMTSALNANAVIFVDQTKASITEIKVDKTIATADNKDTIEYTVKVMKGGNPISGQKVTFSKDFGTLNKTEATTDQNGYATVKLSSGTPGKAIVSAKVSEVNTEVKAATVEFFAPLSIDGNKVTVIGTGVTGSLPKNWLQYGQVKLQATGGNGKYTWKSSNTKIASVDNSGVITLNEKGSATITVVSGDNQSATYTINTPDNIIIAVDKINRMAYSEAESRCQAISSNLAQSKSVLENIYSKWGAANKYPYYSSSNSLTAWIKQSTSDSASGVSNTYDLVTTNSLTNVKATDKNAFAVCVK
What is the function of this protein?
Necessary for the production of attaching and effacing lesions on tissue culture cells.  Believed to mediate adherence.
What are the official names of this protein?
Intimin, Attaching and effacing protein, Eae protein.
What is the protein family that this protein belongs to?
Belongs to the intimin/invasin family.
What are the subcellular locations of this protein?
Cell outer membrane; Single-pass membrane protein.
Protein: CLCC1_RAT
Sequence: MLCSLLLCGCLLLITGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGTSEKKEVNPGLSDAQELSDCLQRLDSLTHKVDDCEKKKMKDYESQSNPVFRRYLNKILIEAGKLGLPDEDRVDVRYDAEILLTRQTLLEIQKFLSGEEWKPGALDDALSDILTNFKSHDAEAWKWQFEDYFGVDPYNVFMVLLCLLCIVALVATELWTYVRWHTQLKRVCIISFLVSLGWNWIYLYKVAFAQHQANVAKMAPLNDVCAKKMDWTENLWEWFRISWTYKDDPCQKYYELLIVNPIWLVPPTKALAVTFTNFVTEPLKYIGKGTGEFIKALMKEIPVLLQIPVLVILALAVLGFCYGAGQSVPMLRHFRGPEREPPRALEPDDRRRQKELDYRFHGGAGDADFSYRGPAGSIEQGPYDKMHVCERDVLRQRQVNMRFPSGNKSPEVLRAFDLPDTEAQEHPEVVPSHKPSIVNTSLKETSELPRESTLAECSQCAKDGSGQVPSTAESSPIVEKAQLKTDSECRPHSTEAAAAAARGTDPVSSPCG
What is the function of this protein?
Seems to act as a chloride ion channel (PubMed:11279057).  Plays a role in retina development (By similarity).
What are the official names of this protein?
Chloride channel CLIC-like protein 1, Mid-1-related chloride channel protein 1.
What is the protein family that this protein belongs to?
Belongs to the chloride channel MCLC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes.
Protein: CH60_STRU0
Sequence: MAKDIKFSADARAAMVRGVDILADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPIGIRRGIEKATSAAVEELKAIAQPVSGKEAIAQVAAVSSRSEKVGEYISEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKVSNIQEILPLLEEVLKTSRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAILTGGTVITEDLGLDLKDATIAALGQAAKVTVDKDSTVIVEGAGSAEAIANRVGLIKSQLETTTSEFDREKLQERLAKLAGGVAVIKVGAATETELKEMKLRIEDALNATRAAVEEGIVSGGGTALVTVIDKVAALELTGDEATGRNIVLRALEEPVRQIAYNAGYEGSVVIDKLKNSPVGTGFNAATGDWVDMIETGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPAAPAMPGGMDPSMMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.