Protein: TPEB_TALSN
Sequence: MGSLSSARESAQRITFFGDQTVDTLLCIKDLANRSHQLPILRRYLREAADKLQLLLSQIELGDYECYRNFETIVELAEIYSKQDGTYEPIGCALWTISQFADYLSRSETDPSILTLSDSAAQPTYVVGVCGGLLLGAAAATARDINELLDIGRKLVDVSFNLGVAQWKRAMDIEGKPGRWAVAIVNVPPKQIRNIITAFNEDMAIPKHRQFYISFLAKGWAAISGPPSIFPELWEYSSTLSSASKMDLPLGTPAHAAHLRSLNIEELIGSGSVLDLPVRQDRLVISTSTCKPFESQTFGSLLSSSLHDITGETLHIAGVNDYVASCLSRETLVQVSSFGPTSQIGSFKKALEDSGLKVDLDLSVPESKTPNLLKNPDARDGSNMIAIVGQSVRLPGSDDVKTFWENLKAGQTFESEIPPSRFDLQNYYDTTGAKKSSVTTRFGHFLDRPGLFDCRLFNVSPREAKQMDPIQRLLLMCSYEALQTAGYSPDSSLSTNRMRVATYFGQSGDDWRQGRASQDVDIYYIPGTIRSFAPGKLNYHYKWGGGNYSVDSACAASTTSVIMACNALLGRECDMALAGGGQLHLEPENYAGLSRAGFLSKTTGGCKTFREDADGYCRGEGIGVVVLKRLEDALADNDNVLAVVRGADRNYSWDASSITHPSANAQATVIQRVLRNTGVEPADIGFVEMHGTGTTAGDSVEMKTVTTVFGSRPKDNPLYIGAVKANFGHGEAAAGITSLLKAVQMLGQKTIPRQPGFPGPKDPTFDHLDAMNIRIPDSSFPFPTPTRPFSQDGKMRILVNNFDASGGNNCVLLEEAPDKNVSQIQDPRQYYTVAISARTTKSLQKNMERLSDYLVKHPDTPVADVAYTSTARRIHEDLKRSYTVDSTESLVGLLQADLKKDLTGIRPATPRSVVFAFTGQGSQYSGMTKQLFETCTPFRESVQSLHDLAVWQDFPSFLNLFTDDVTDEISASPIQTQLAIVVLEMSLANLWKSWGVEPDLVIGYSLGEYVALYVSGVLSAHDVLFLVGNRAQLMDERCEIGSYSMLAVQASPEDLEEPLKAYPTSNVACRGAPRSTVVSGPSEDIAKLHAELKEKSISGTILNVPYGFHCAQVDPILEDFRDLLDRVPFSKPRIPVASSLDGVIVTDDDVFSPSYMVRQTREPVAFVSALKAIETSHLVDNTSLWVEIGPKRVLNSFIKATLAVDHDRLLHSVDEKASNWRTIATAITACWQGGVSIKWQNFHRQFTKHLRLVDLPTYAFDLKDYWIEPAAPIVQQRSAAEPLRQVAVPAVPGFPTASLQRVREERIQGDNAAVTFESTLSHPDLMGLIRGHQVNGVDLFPASGWWDMAYTAAKYIHHRIQPSRGAAPGLSMLDCSITHPLMPSASEDQQKLVIIVAKKQAGSSVVEVSFKSQEKSVEQDHGSCKIRFESKADWEAEWSRSAHFIKAAKNNVVTNATRPDGNGHKLPKPVVYTLFSNFVNYSGDFKGIQQVYLNADFQREVVADVVLPAGMYNFNLNPYWSDALIHACGFMLHSDPDLPTQDCFLFNGFEELRFLMDDLLPGVPYTSYVFMHDTNSQEVPAKRTRNVTGDIYIFQGEKIVGTVQGVVFQRLTKRILTTILGKSQDHHNSNEVRNGNATTTHTNPPAHATTQSFFAPPGIKPAVAFSSAPATVGEETAEAVIAKILTKTGANRASLSESTTLGEIGLDSLEWIELVGVFRSALDIEVPASFFFEYPKVLRLRQAIAELPLEGEKEESGSSSPDSPYGMLTPATGRFTPITASRSTHNSDGPANYANIVLDIVLSQTGFDKDDVLPSTRFDDMGLDSLCTMEVVSLVREQTGLDLPASFFHHHPTVADVRKNLGPNTEDKSKDSVKASASIAVSEPATELVVVHHPGNSPAPESLPIIDEDLKDYHCDFFLMQGSSDSAEIPMFFLPDGTGYPAVLLKLPPVFKGDNPLFTCKSPLLHRAEGREVACTIEGLALSYAEAIRRTRPHGPYLLAGYSLGAAYAYEVAKILADAGEIVQGLLFVDFNMAASVGLEHRERKPVPTNLNVGVMEQVGWMNGIHNDEKNFHIPPAPPKIKFHALSVFKSLTRYFPKPMTPSQRPRNTYALWAGAGMEDLLGPSNAGFLPEFGIIDWQMGSRRENNGPAGWENFIGGPVRCATVPCDHLSIMMSTDWVGTTANIIKDLLEDALSNPGTP
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of polyesters containing 2,4-dihydroxy-6-(2-hydroxypropyl)benzoate and 3-hydroxybutyrate moieties, such as talapolyester G, 15G256beta and 15G256beta-2; as well as to oxidized derivatives such as 15G256alpha (PubMed:35889347).  The biosynthesis of the polyesters probably starts with the formation of the diketide 3-hydroxybutyryl-S-ACP catalyzed by the partially reducing polyketide synthase tpeA (Probable).  The acceptance of 3-hydroxybutyryl by the non-reducing polyketide synthase tpeB would initiate further elongation and cyclization, catalyzed by KS and PT, respectively, to form 2,4-dihydroxy-6-(2-hydroxyn-propyl)benzoyl-S-ACP intermediate (Probable).  The TE domain could catalyze lactonization at this step to yield 6-hydroxymellein as a derailment product (Probable).  The polyesterification process maybe occurs when additional molecules of 3-hydroxybutyryl are transferred to tpeB (Probable).  Following the first esterification step, an intramolecular cyclization catalyzed by the TE domain of tpeB would give talarodioxadione 1, whereas the ethyl esterification of talapolyester G perhaps happens spontaneously (Probable).  Further oxidation by the cytochrome P450 monooxygenase tpeC then leads to the formation of oxidized derivatives (Probable).
What are the official names of this protein?
Non-reducing polyketide synthase tpeB, NR-PKS tpeB, Polyesters biosynthesis cluster protein B.