PharMolix/UniProtQA huggingface dataset:
Protein: PETD_CUCSA
Sequence: MGVTKKPDLNDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVILGTIACNVGLAVLEPSMIGEPADPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMVSVPAGLLTVPFLENVNKFQNPFRRPVATTVFLIGTAVALWLGIGATLPIDKSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y1498_MYCTU
Sequence: MRCIIKRLFQNILTRSKRGSADGGSAEALPPKSLRQFVGGAYKEVGAEFVGYLVDLCGLQPDEAVLDVGCGSGRMALPLTGYLNSEGRYAGFDISQKAIAWCQEHITSAHPNFQFEVSDIYNSLYNPKGKYQSLDFRFPYPDASFDVVFLTSVFTHMFPPDVEHYLDEISRVLKPGGRCLCTYFLLNDESLAHIAEGKSAHNFQHEGPGYRTIHKKRPEEAIGLPETFVRDVYGKFGLAVHEPLHYGSWSGREPRLSFQDIVIATKTAS
What are the official names of this protein?
Uncharacterised methyltransferase Rv1498c.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: TYSY_BDEBA
Sequence: MKQYHDLIKTVLEHGVKKEDRTGTGTISMFGYQMRYNLQEGFPLLTTKKLHTRSIFHELLWFLKGETNIKYLHDNKVTIWDEWADENGNLGPVYGKQWRSWETADGRTIDQITNVVEQIKKNPNSRRMLVVAFNPGDVDKMALPPCHAFFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQVCDLEVGDFVHTLGDAHLYLNHLEQANLQLTREFRPLPQLKLNPAKKDLFDFTYEDIEIIGYDPHPAIKAEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MET16_CAEEL
Sequence: MSQNNEMHPRNPYRNKPPDFKALAVEYPEFRKFCQYVSNGKVTFDFKKDAAVRCLTQTLLKKDFNLDVEIPPGHLVPRVPQKLNYCLLIDDLLKANKLTKNVIGIDIGTGTSCIHALIGARQFNWKFIATDGDEKSVRVAHENVAKNGLSSSICVVHVNPDVKTVLMDVVNTIPDTDYAFCMCNPPFFEKGNGDDKFCEDISSSTETYSNRVASEFRTAPHSATFASSAELFVDGGEVAFVNRIIDDSVLLRDRIKIYTTMIGRKSSLKPLQNRLQRFGDDVKIMISVLNQGKTKRWMLAWTFSKSVSLTTIDRPISFQCPKPGLTRLMQEISILNGRLRQEDTLAIVAEFKCVTWTNQRARKRAKAILSESSIKKAKWNFSNVACQVAFGAGDGKDSYTDAGNFVSSESIPTNNLNAWDNASQAYFPLPNGEVPGPIIRIRIQVFSEDSYDSISFELISGSKQHLHQLVQYLKNLICR
What is the function of this protein?
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5) (PubMed:33930289).  Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence (PubMed:33930289).  Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:33930289).  In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA) (PubMed:33930289).  Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development (PubMed:19596901, PubMed:19752194).  Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate (PubMed:19596901, PubMed:19752194).  Plays a role in the development of the vulva, somatic gonad and embryo (PubMed:19596901).
What are the official names of this protein?
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase, N6-adenosine-methyltransferase mett-10.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates in nuclei as cells enter meiosis (PubMed:19596901, PubMed:19752194). During meiotic prophase, expression is predominantly nuclear, but does not co-localize with DNA (PubMed:19596901). Recruited to the nucleus by dlc-1, a component of the dynein complex (PubMed:19752194).
Protein: BFD_SALTI
Sequence: MYVCLCNGISDKKIRQAVRQFHPQSFQQLRKFIPVGNQCGKCIRAAREVMQDELTQMPEFKEIA
What is the function of this protein?
Seems to associate with BFR; could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR.  Could participate in the release or the delivery of iron from/to bacterioferritin (or other iron complexes) (By similarity).
What are the official names of this protein?
Bacterioferritin-associated ferredoxin.
Protein: IR31_HAEIF
Sequence: KFKVVTTFTVIQDIAQNVAGDAAT
What is the function of this protein?
May be involved in iron uptake.
What are the official names of this protein?
Iron-regulated 31 kDa protein.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS2_RICFE
Sequence: MSKIPSVNIKELLDAGVHFGHKTSRWNPKMASYIYGERDDVHIIDLRQSAALMSVALNTIYETVKKDGKILFVSTKIQASDIIAEYAEKCGQYYVNHRWLGGMLTNWKTIAGSIEKLNKLEKTLENEEALMGYTKKEILDMSRKKEKLLLSLAGIRNLNSKPDLLVVIDTNKEHIAINEAVKLNVPIVAVVDTNSNPDNVNYPIPGNDDSIRSIRLYCSLFADAALQGLEESMKASGVDMGAMQEHTDKALTSKNVSKLKQAKKFSKTKNIDEETNTEFEQALNDADENKNSDNA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SYE_MYCVP
Sequence: MTTSDVVRVRFCPSPTGTPHVGLIRTALFNWAYARHTGGTFVFRIEDTDSARDSEDSYLALLDALRWLGMDWDEGPEIGGPYGPYRQSQRLDIYTDVIERLLAAGEAYEAFSTAEEVEARHIAAGRNPKLGYDNYDRDLTEEQRAAFRAEGRRPVVRLRMPDTDLTWVDLVRGETTFPAGSVPDFALTRGNGEPLYPLVNPVDDALMKITHVLRGEDLLPSTPRQLALYGALIRIGVADTTPQFAHLPSVLGEGNKKLSKRDPQSNLFLHRDRGFIPEGLLNYLALLGWSIADDHDIFSLEEMVAAFDVADVNSSPARFDQKKADALNAEHIRLLDEAEFARRLGAYFATHGHRTGLDDAQFAEAARLVQTRIVVLGDAWELLKFLDDASFTLDEKSAAKELKAEAVPVLGAALEALRGVEAWDTAAIEEALKGALIDRLELKPRKAFGPVRVAATGSSVSPPLFESLELLGRDRSLARLQAGRDHAAAAAAPQG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_VIBC3
Sequence: MNKQVEIFTDGSCLGNPGPGGYGIVMRYKQVEKTLARGYRLTTNNRMEMLAAVMALQALKEPCRVILTTDSQYVRQGITQWIHNWKLRGWKTADKKPVKNADLWQALDKETARHQVEWRWVKGHAGHRENEMCDELARQAAENPTEDDIGYQPEPQ
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLD4_HUMAN
Sequence: MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV
What is the function of this protein?
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney.  Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts.  Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
What are the official names of this protein?
Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=CLDN4 is required for tight junction localization in the kidney.
Protein: YPEB_OCEIH
Sequence: MFRWIAIGVLSVAVIGTAVWGYNEYSEKNEIKIQAENEYQRSFHELTYYMDLLNDEIGTALAMNSKERLSPQFVDIWRLTSQAHSNVGQLPLGLLPFHKTEQFLSDIGEFTYQTAVRNLDDNPLTEEETQKLKDYYDQSGQIKDELRQVQHVALEEGLNWMDVELALSDENAQQDNTIVNGFQTVEKSVEGFGQADPENSTISTNTQDHSYKNLTGSEVTENEALQRAMEIFEIKDKDLLSISKSGEGADTPLYSISYNKDEEHGYMDMAIKGGHPLNLLVSREMKEKKVSLNEGSEKAKDYLASFGLEDMTLFQSSEYDHIGVYSYLYNDNGVRVYSDAVEVKVGLDNGDLLGLTTNSYFMNHTDREIPEPKISEDEARDNVNSTVDIQESHLAIIDNNAGEEVLTYEFLGIMDDETYRIFINAENGQEELVEKLDGKEVNYNSVL
What is the function of this protein?
Required for spore cortex hydrolysis during germination.  Appears to be required for either expression, localization, activation or function of SleB (By similarity).
What are the official names of this protein?
Sporulation protein YpeB.
What is the protein family that this protein belongs to?
Belongs to the YpeB family.
Protein: METN1_YERPS
Sequence: MISIERLSKTYPQGGLPMVALEEVSLEIPTGSVFGIVGRSGAGKSTLIRCLNLLERPTSGRIQVDGRELTTLSDRELRLQRQNIGMIFQNFHLLHSRNVWDNIAVGLEIIGMPKAQRQQRVAELLDLVGLSDKAYAFPSQLSGGQKQRVGIARALAAKPSYLLSDEATSALDPETTASILALLSDINRQLGLTIVLITHELDVVKSICDNAALLETGRVVETGAIADLLSDPLSRLGRSLLPTCGPLSVSATPRAELTFFDTLAASPVLSALAQQHAVGVTLLGGGVEFIGGQRVGRLHVDFNRPEGGLNLAEVLQFLNDRGVRAELI
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KAD_DECAR
Sequence: MKLILLGAPGAGKGTQATFISKQFGIPQISTGDMLRAQVKAGTALGLEAKKHMDAGGLVPDAVIIGMVKDRLTQDDCKNGYLFDGFPRTIPQAQAMKDAGVPIEFVLEIDVPDSDIVERMAGRRAHLASGRTYHVKFNPPKVEGIDDVTGEPLVQRDDDKEETVKKRLEIYHSQTKPLVDFYGKWAAEGDAKAPKVRKVAGVGSVDNITKSVFEALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCL3_PYRTR
Sequence: MRWPWSGDDHEQNKSSRLWATSPKSSDWPSTLVEPRTLIATLALTVSTVAGVRLYKTYLRRIPTVNHIKPNYFRRKSLFGQVTSVGDADNFRLYHTPGGRIAGWGLLPWKRIPTKREDLTKQTLHIRIAGVDAPELAHWGREAQPFSKEAHDWLINLIHNRRVRAYIYRRDQYDRVVAQVYVRRWLFRKDVGLEMLRAGLATVYEAKTGAEFGTVEDKYRAAEQKARDSKVGMWAKPTLRQRLGGAPTQPPESPREYKNRHNAAEKLKKPG
What are the official names of this protein?
Probable endonuclease lcl3.
What is the protein family that this protein belongs to?
Belongs to the LCL3 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single- pass membrane protein.
Protein: RL29_MYCA9
Sequence: MTVGISAGELRESTEEELITKLRESKEELFNLRFQMATGQLANNRRLRAVRQEIARIYTVMRERELGLAAGPDSEDSK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: SFH3_ARATH
Sequence: MTDTMSAHMDRHNKLDYDGSEDEKKTKLCSLKKKAINASNKFKHSFTKRTRRNSRVMSVSIVDDIDLEELQAVDAFRQALILDELLPSKHDDHHMMLRFLRARKFDLEKAKQMWTDMIHWRKEFGVDTIMEDFDFKEIDEVLKYYPQGYHGVDKDGRPVYIERLGQVDATKLMQVTTIDRYVKYHVREFEKTFNIKLPACSIAAKKHIDQSTTILDVQGVGLKSFSKAARDLLQRIQKIDSDNYPETLNRMFIINAGSGFRLLWSTVKSFLDPKTTAKIHVLGNKYQSKLLEIIDSNELPEFLGGNCTCADKGGCMRSDKGPWNDPDIFKMVQNGEGKCPRKTLSNIEEKTISVDENTTMKSDSFAKNKFDAENTKFIPMIDKTVNASTWPTNLHKSNYPEPEDLYSAVKPSQRRGGEGYLFGGVMSLVMGLMTVVRLTKNMPRKLTEAAIYGGEVDKAETTMVSNQEYMSMVKRMAELEEKCRSLDNQPAAFSPEKEQILTAALSRVDELELQLAQTKKTLEETMATQHVIMAYIDKKKKKKKFFGF
What is the function of this protein?
Required for transport of secretory proteins from the Golgi complex (By similarity).  Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro.
What are the official names of this protein?
Phosphatidylinositol/phosphatidylcholine transfer protein SFH3, Protein SEC FOURTEEN HOMOLOGS 3, AtSFH3.
What is the protein family that this protein belongs to?
Belongs to the SFH family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Protein: KINH_DORPE
Sequence: MDVASECNIKVICRVRPLNEAEERAGSKFILKFPTDDSISIAGKVFVFDKVLKPNVSQEYVYNVGAKPIVADVLSGCNGTIFAYGQTSSGKTHTMEGVLDKPSMHGIIPRIVQDIFNYIYGMDENLEFHIKISYYEIYLDKIRDLLDVTKTNLAVHEDKNRVPFVKGATERFVSSPEEVMEVIDEGKNNRHVAVTNMNEHSSRSHSVFLINVKQENVETQKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALADGNKSHVPYRDSKLTRILQESLGGNARTTMVICCSPASYNESETKSTLLFGQRAKTIKNVVSVNEELTADEWKRRYEKEKERVTKLKATMAKLEAELQRWRTGQAVSVEEQVDLKEDVPAESPATSTTSLAGGLIASMNEGDRTQLEEERLKLYQQLDDKDDEINNQSQLIEKLKEQMMEQEDLIAQSRRDYENLQQDMSRIQADNESAKDEVKEVLQALEELAMNYDQKSQEVEDKNKENENLSEELNQKLSTLNSLQNELDQLKDSSMHHRKRVTDMMINLLKDLGDIGTIVGGNAAETKPTAGSGEKIEEEFTVARLYISKMKSEVKTLVSRNNQLENTQQDNFKKIETHEKDLSNCKLLIQQHEAKMASLQEAIKDSENKKRMLEDNVDSLNEEYAKLKAQEQMHLAALSEREKETSQASETREVLEKQMEMHREQHQKQLQSLRDEISEKQATVDNLKDDNQRLSLALEKLQADYDKLKQEEVEKAAKLADLSLQIDRREQAKQDLKGLEETVAKELQTLHNLRKLFVQDLQNKVKKSCSKTEEEDEDTGGNAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATMERVKSLESALKDAKEGAMRDRKRYQHEVDRIKEAVRQKNLARRGHAAQIAKPIRPGQHQSVSPAQAAAIRGGGGLSQNGPMITSTPIRMAPESKA
What is the function of this protein?
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
What are the official names of this protein?
Kinesin heavy chain.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon.
Protein: CD123_DANRE
Sequence: MKKEQVVNCQFSVWYPLFKKHTIKSLILPIPQNVIDYLLDDGTLVVSGSENNNSQTQANNSDSDEEDIQWTDDETTTTVTAPEFPEFNVKVQEAINVLGGCIFPKLNWSAPRDANWIALNSSLQCQSLSEIFLLFKSSDFITHDLTQPFLHCSDDSPDPTINYELVLRKWSELIPGGEFRCFVKENKLIAICQRDYTQHYQHIGKQEASISTSILQFFRDNIQYQFPDEDFVLDVYRDSSGRVWLIDFNPFGEVTDSLLFTWEELTSGKNLTANQTQEETALPDGPAFRCTNSEVTVQPSPCLSYRIPRDFLDLTTGEDAYKLIDFLKLKRGQQEEEEESNEEGEEPQ
What is the function of this protein?
Required for S phase entry of the cell cycle.
What are the official names of this protein?
Cell division cycle protein 123 homolog.
What is the protein family that this protein belongs to?
Belongs to the CDC123 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALG3_NEOFI
Sequence: MDLKHTLRDLCMNPRHTRWVAPLLILGDAVLCALIIWKVPYTEIDWTTYMQQISLYISGERDYTLIKGSTGPLVYPAAHVYIFNILYHLTDEGRDIFLGQILFAILYLATLTVAMTCYRQAGAPPYLLVPLVLSKRLHSVFMLRLFNDGFAAYAMWVSILLFMNKKWTAGAIVWSTGVGIKMTLLLLAPAIAVVLVLSLSLGPSMQLGFLAVLIQVLFGIPFLQNNPAGYVSRAFELTRQFMFKWTVNWRFVGEELFLSRKFSLALLALHILLLGLFVATVWLKPSGSDLPSFLQRLIQRRYRTASLSKSFIMTAMLSSLAIGLLCARSLHYQFFAYLACATPFLLWQAGFHPILVYVVWVAQEWAWNTYPSTNASSLVVILSLAAQVFGVLGNSFSRKHLDQSSQKEHLQ
What is the function of this protein?
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
What are the official names of this protein?
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase, Asparagine-linked glycosylation protein 6, Dol-P-Man-dependent alpha(1-3)-mannosyltransferase, Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: EFTS_MYCBO
Sequence: MANFTAADVKRLRELTGAGMLACKNALAETDGDFDKAVEALRIKGAKDVGKRAERATAEGLVAAKDGALIELNCETDFVAKNAEFQTLADQVVAAAAAAKPADVDALKGASIGDKTVEQAIAELSAKIGEKLELRRVAIFDGTVEAYLHRRSADLPPAVGVLVEYRGDDAAAAHAVALQIAALRARYLSRDDVPEDIVASERRIAEETARAEGKPEQALPKIVEGRLNGFFKDAVLLEQASVSDNKKTVKALLDVAGVMVTRFVRFEVGQA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOX9_PONPY
Sequence: MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAPQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP
What is the function of this protein?
Transcription factor that plays a key role in chondrocytes differentiation and skeletal development.  Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6.  Also binds to some promoter regions.  Plays a central role in successive steps of chondrocyte differentiation.  Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes.  Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis.  Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression.  Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C.  Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation.  Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes.  Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors.  In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix.  Controls epithelial branching during kidney development.
What are the official names of this protein?
Transcription factor SOX-9.
What are the subcellular locations of this protein?
Nucleus.
Protein: BIOD_LEGPH
Sequence: MKRYFVTGTDTDCGKTFVTNQLVNYFSDSAAIKPIASGCEYSENQLVNSDALLHQQQNHLPMEIVNPWRFRLPVSPHLSAREDGASIDVHKVADYCLNLQVNDIKKLFIEGAGGLMVPLNEQDTWLDFLKLTRIPVILVVGMKLGCINHTLLSQEVLEINKIKCQGWIANCLDQDMLMLDENISTLEAKLNYPLLARTNYGGKISDICLSSL
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRBL2_HUMAN
Sequence: MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW
What is the function of this protein?
Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation.  May also play a regulatory role in the cell cycle.  Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.
What are the official names of this protein?
cAMP-responsive element-binding protein-like 2.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ANFC_PIG
Sequence: MHLSQLLACALLLTLLSLRPSEAKPGAPPKVPRTPPGEEVAEPQAAGGGQKKGDKTPGGGGANLKGDRSRLLRDLRVDTKSRAAWARLLHEHPNARKYKGGNKKGLSKGCFGLKLDRIGSMSGLGC
What is the function of this protein?
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity).  May also be vasoactive and natriuretic.  Acts by specifically binding and stimulating NPR2 to produce cGMP.  Binds the clearance receptor NPR3 (By similarity).
What are the official names of this protein?
C-type natriuretic peptide.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: HVRB_RHOCB
Sequence: MSEIDWRKMPPLTALRAFAATASEGGFSAAARKLNVTHAAIAQQVRALEADLDVPLVWRDGKHLHLTPEGERFAKALADGFSMIQSAADMLRADTSEKALTVTVPPVFASEWLMPRLARFWKKHPDIPLSLLPDARLVDLKEIGANIGIRFGVGKWPGVISVFLTAAPQVVVAAPELLGGRKKLSLREMAMLPWVREGDWPEQMQLLESMGLVPAALKFVDFPNEELALAAAREGIGLHLETEALIVEDLKLGWLVKIHELTEESLGYYIVRPPGRLNPAAKIFIDWLKAEA
What is the function of this protein?
Functions as a low-light activator of ahcY expression (gene for S-adenosyl-L-homocysteine hydrolase) and as a high-light activator of an uncharacterized 21. 6 kDa protein in the ahcY-hvrB intergenic region (orf5).  It is also a negative regulator of its own expression.
What are the official names of this protein?
AhcY transcriptional activator HvrB.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: 2A5B_ARATH
Sequence: MFKKIMKGGHRKPSKSEANEPSSYGIGLPDNRSGPGSNVVVSHASRGALVNSSPSPVTATPPPPPLGSVEPLPLFRDVPVSERQTLFLRKLQNCCFLFDFTDTIKNARDKEIKRQTLLELVDFIQSGSSKISESCQEEMIKMISVNIFRSLPPASHENTGQEPADPEEEEPYLEPSWPHLQLVYELLLRYVVSTDTDTKVAKRYIDHSFVLKLLDLFDSEDPREREYLKTILHRIYGKFMVHRPFIRKAINNIFYRFIYETERHSGIGELLEILGSIINGFALPMKEEHKLFLIRVLIPLHKPKPIVVYHQQLSYCIVQFVEKDYKLADTVIRGLLKYWPVTNCSKENLFLGELEEVLEATQPVEFQRCMVPLFQQIGRCLTSSHFQVAERALFLWNNEHIVGLIAQNRSVILPIIYPTLEKNIQSHWNQAVHGLTTNIKKMFMEMDPELFEECQRQYEEKQAKSKEVEEQRQYTWKRLAEAAAERDGGGGEEDHMITS
What is the function of this protein?
The B regulatory subunit may modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).  Required for the formation of the PP2A holoenzyme that positively regulates brassinosteroid signaling by dephosphorylating and activating BZR1 (PubMed:21258370).
What are the official names of this protein?
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform, AtB' beta, PP2A, B' subunit, beta isoform.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B56 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.