PharMolix/UniProtQA huggingface dataset:
Protein: SECR_RABIT
Sequence: HSDGTLTSELSRLRDRARLQRLLQGLL
What is the function of this protein?
Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis.  Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells.  Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content.  Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity).  Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid.  In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation.  Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation.  Also able to stimulate lipolysis in white adipocytes (By similarity).  Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity).  Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity).
What are the official names of this protein?
Secretin.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: RODA_MYCBO
Sequence: MTTRLQAPVAVTPPLPTRRNAELLLLCFAAVITFAALLVVQANQDQGVPWDLTSYGLAFLTLFGSAHLAIRRFAPYTDPLLLPVVALLNGLGLVMIHRLDLVDNEIGEHRHPSANQQMLWTLVGVAAFALVVTFLKDHRQLARYGYICGLAGLVFLAVPALLPAALSEQNGAKIWIRLPGFSIQPAEFSKILLLIFFSAVLVAKRGLFTSAGKHLLGMTLPRPRDLAPLLAAWVISVGVMVFEKDLGASLLLYTSFLVVVYLATQRFSWVVIGLTLFAAGTLVAYFIFEHVRLRVQTWLDPFADPDGTGYQIVQSLFSFATGGIFGTGLGNGQPDTVPAASTDFIIAAFGEELGLVGLTAILMLYTIVIIRGLRTAIATRDSFGKLLAAGLSSTLAIQLFIVVGGVTRLIPLTGLTTPWMSYGGSSLLANYILLAILARISHGARRPLRTRPRNKSPITAAGTEVIERV
What is the function of this protein?
Transglycosylase involved in peptidoglycan cell wall formation.  Required for the regulation of cell length.
What are the official names of this protein?
Peptidoglycan glycosyltransferase RodA, Non-canonical transglycosylase RodA.
What is the protein family that this protein belongs to?
Belongs to the SEDS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: STAD_GOSHI
Sequence: MALNFNAIASKSQKLPCFALPPKATLRSPKFSMISTIPSGSKEVGNLKKPFTPPKEVPVQITHSMPPHKIEIFKSLEGWAENNILTHLKPVEKCWQPADFLPDPNSDGFHEQVKELRERAKEIPDDYFVVLVGDMITEEALSTYQTMLNTLDGTRDETGASLTPWAIWTRAWTAEENRHGDLLNKYLYLSGRVDMRQIERTIQYLIGSGMDPHTENSPYRGFIYTSFQERATFISHGNTGRLAKEYGDINLAQICGSIASDEKRHETAYTKIVEKLFEIDPDETVLAFADMMKKKIAMPAEFIYDGRDYNLFDHYSAVAQRIGVYTAKDYVDIVEHLVDRWKVKELAGLSAEGRKAQDYLCSLPSRIRRLEERAQEKAQGSTPVSPFSWIFDREVKL
What is the function of this protein?
Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain.
What are the official names of this protein?
Stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic, Stearoyl-ACP desaturase, Acyl-[acyl-carrier-protein] desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid. Note=In green tissue, found in chloroplasts. In non-photosynthetic tissue, found in plastids.
Protein: MUTL_SALAR
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQSEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVARDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVADPNHTTTALAEIQYCYVNGRMMRDRLINHAIRQACEEKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEEIAPAPRHVPENRIAAGRNHFAEPVVPTAAREPATPRYSGGASGGSGGRQSVGGWSHAQPGYQKQQGEVYRALLQTPAASSTPEPVAPALDGHSQSFGRVLTIVGGDCALLEHGGNIQLLSLPVAERWLRQAQLTPGQSPVCAQPLLIPLRLKVSADEKASLQKAQPFLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: KATG_RHOPT
Sequence: MDAKTDDKGAGKCPFSGGSHGHRNRDWWPDQLDISVLHNNSKKSDPMGAAFNYAEEFKKLDLEAVKKDLHALMTDSQEWWPADFGHYGGLFVRMAWHSAGTYRITDGRGGAGAGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGSKISWADLMVLTGNVALESMGFKTFGFAGGRADVWEPEELYWGPEGTWLGDERYSGERQLAEPLGAVQMGLIYVNPEGPNGNPDPVAAAKDIRETFARMAMDDEETVALIAGGHTFGKTHGAGDPSLIGPAPEGGLLEEQGLGWTSKYGSGFGADAITGGPEVIWTQTPTQWSNHFFENLFGFEWELDKSPAGAKQWKAKGAEATVPDPFDPAKKRVPTMLTTDLSLRFDPIYEKISRRFLENPDQFADAFARAWFKLTHRDMGPRERYLGPEVPKEELIWQDPIPAVNHELVGEADIEALKAKILASGLSVAQLVSTAWASASTFRGSDKRGGANGARIRLAPQKDWEVNQPAELAQVLSKLEAIQGEFNGAQKDGKKVSLADLIVLGGAAAIEKAAKDAGTAVKVPFTPGRMDASAEQTDVESFKVLEPRADGFRNYINTKRHQFMHPEEALVDKAQLLTLTGPELTVLVGGLRVLGANYAHSTHGVLTERPEKLTNDFFVNLLDMGTKWTKANGEVEIYEGRDRKNGELKWTGTRVDLVFGSHSQLRAFAEVYACSDAQEKFVSDFVAAWSKVMNADRFDIVAKKQAA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: TRUA_VIBVY
Sequence: MRIALGIEYNGTDYFGWQRQREVASVQEKLEKALSKVANHPVEVQCAGRTDAGVHGTGQVVHFDTNVERKMVAWTMGANANLPKDIAVRWAKAVPDEFHARFSATARRYRYIIFNHALRPGILGSGVSHYHGELDEKKMHEAGQYLLGENDFTSFRAVQCQSLSPFRNMIHLNVTRHGHYVVIDIKANAFVHHMVRNITGSLIMVGRGEQDPEWIKWLLEAKDRKLAGPTAKAEGLYLVDVDYPEEFDLPRESIGPLFLPDNLN
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GRAN_HUMAN
Sequence: MAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI
What is the function of this protein?
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin.  May play a role in the formation of focal adhesions.
What are the official names of this protein?
Grancalcin.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels.
Protein: GRPE_STRP1
Sequence: MAVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDEHPADSIAEVFQKGYKLHERLLRPAMVVVYN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBL2_SAGOE
Sequence: MSPFLSLPLLLLSVLSASYSETVTSEDAQKTCPTVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGAKGQKGDPGASPDGDSSLAASERKALQTEMARIKKWVTFSLGKQVGKKLFLSNGETMTFDKVKALCAQFQASVATPMNQAENTVIQNLVKEEAFLGITDEETEGQFVDLTGRRLTYTNWNQGEPNNADSREDCVVLLRSGGWNDVPCSSSHLAICEFPV
What is the function of this protein?
Calcium-dependent lectin involved in innate immune defense.  Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.  Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
What are the official names of this protein?
Mannose-binding protein C, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin.
What are the subcellular locations of this protein?
Secreted.
Protein: ROAA_EUGGR
Sequence: MFSFFYRFNWNFIKWNLVDNTVSLTQHKIYLASKKSDIFLVKNKQRRFFKSFYAHIFSVRNCFEKFPSLQSYFYSSKDKFFLVSLLSSKRNLFLHGFFYNIKKAFLFYSYDFFLLYKLSFSLLLTSTLLPYINDINPCFIKDYYFFVEGNFFDFEQILIDVFKYSYYFKVENFKFLYFARFSWIYKNFPLDVNFLKNFLDRKNLVFFKSLFLIIFNFIFNGLNFFFQENFFISYKVYYLFYIDKFYFFFKFPYDFFICKKIIISFFSLRGIILNININSFYRFETFVFNFFIFDFLRFGSNILLHINKKHIQFYKLSLKMIVKMFLKKSVFFLVNLLNKKILDCLNRGFFCFNNNFLFLELDLYLYRLLWRYIKKLHSRKTRTWIYSKYWKFFSGIWRFFITDIKTGNFLFLKSHLYSSKYFYSYRNMKFKISNTLNIFNLYNKGKLERMIFEKFKYKFSPNFIVLYNNQRGLCFFCKKSIYSNRFVILNIKKWNFSFFENLILIHFYCNNFNQLQ
What are the official names of this protein?
Ribosomal operon-associated A protein, RoaA.
What is the protein family that this protein belongs to?
Belongs to the roaA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: S52A2_RAT
Sequence: MAAPPLGRLVLTHLLVALFGMGSWIAVNGIWVELPVVVKELPEGWSLPSYLSVLVALGNLGLLLVTLWRRLAPGKSERIPIQVVQGLSIVGTGLLAPLWSNMALVAGQLHSVAFLTLAFVLALSCCASNVTFLPFLSHLPPPFLRSFFLGQGLSALLPCVLALAQGVGRLECLHVPANGTTGPPIKVSPINFPERFSAGTFFWVLTALLGTSAAAFQGLLLLLPSPPPEATMGTGLRVETPGTEEEEEEEEASPLQEPPGQVASIVSSPDPKAHRLFSSRSACLLGLLAITNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSSANPLACFLAMAVLCRSLAGLYGLCLLGMFFGTYLMTLAVLSPCPPLVGTSAGVVLVVLSWVLCAGVFSYIKVATSSMLHSGGRPALLAAGVAIQVGSLLGAIAMFPPTSVYPVFRSGEDCVDQCGP
What is the function of this protein?
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.  May also act as a receptor for 4-hydroxybutyrate.
What are the official names of this protein?
Solute carrier family 52, riboflavin transporter, member 2, Porcine endogenous retrovirus A receptor 2, Protein GPR172B, Riboflavin transporter 1, rRFT1.
What is the protein family that this protein belongs to?
Belongs to the riboflavin transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEU1_ECOLU
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRATEVEKELQRKAQHNENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: MURI_YERPS
Sequence: MATKPQDANTTSREAITSKADSPPRPTALIFDSGVGGLSVYQEIRQLLPNLHYIYAFDNVAFPYGEKSGEFIVERVLEIVTAVQQSHPLAIVVIACNTASTVSLPALRERFAFPVVGVVPAIKPAVRLTRNGVVGLLATRATVHASYTLDLIARFATDCKIELLGSSELVEVAETKLHGGVVPLEVLKKILHPWLSMREPPDTIVLGCTHFPLLTEELAQVLPEGTRMVDSGAAIARRTAWLISSQENVISSQDENIAYCMALDEDTDALLPVLQSYGFPKLQKLPI
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: FB1_ARATH
Sequence: MATDDDGTPNWSELVTDILSLVFKHLSFTDFARAKTVCSSWYFASKSSSPRKNHTPWLILYQDTHWLMFNSDEEKFYRTVYLGRFAECRGVASCGSWVLVFDKEINFYIINPFTPQLIRLPPLEYSNTGTKFERPGNYVFHLLFDDRHRTSRAIVGNSVLWVDEKTKDYLVVWSYKEAFVPSPYIYYCSKRGQEWFEIPASTCGKLFRCLDMAYKDEKLYILTSNGSIRILDFSLGDLPRQIDNHPYSHRPFVTEFPNHKMGMRLTTSGDVVMIQCVTTGTHKRSPFRIFKLSSITETKESSHEVVGWETVHSFEDEESLVWDLSVTLPTKGVSGIKKDSIYYCHTSLSSSIRETCAYEIPTHKITAYDIPKQDIKPIRHRGILIGEARWFVPCFGAGE
What are the official names of this protein?
F-box protein At1g10110.
Protein: TRMB_THET8
Sequence: MLVVPARLHRWPPEVQDLFGREGPLVLEIGFGDGRFTAELARSRPDWLVLGAEVSAASVLRALRRMRREGLANVRLYHGQGPFALRNLVLPGTLDQVIVNFPDPWPKKRHQERRLLREAFFRRLSTRLKPGGSLLLTTDHEEYFRFALEEAERTGLYRVEVRPPPEAHLRTKYALKWKEAGRAFFHAAFIKLREDPAPWPPLRRYDVAHALLSGELPQDLALEKTPVRLKEGVAVFLEVARGKEGFYVLTHVEEEDLTQDLLLEVRKSARGVYAGVSRFGSPLITEAVKGAVRALVDRLEAHGLEVVQDHT
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: PROA_STREM
Sequence: MMTIEQLGQRAKVASRALVSLTTKDKNQFLAFLAEELVAQTDMILAENAKDLAKAAEHGISEIMCDRLRLTADRIHAMAHGVRQVADLADPIGEVIKGYTNLDGLKITQKRVPLGVIAMIFESRPNVSIDAFSLAFKTNNAIILRGGKDALYSNMALVKLVRNALEASAITPDAVQLIEDTSHAVAEELMQATDYIDVLIPRGGARLIQTVKEKAKVPVIETGVGNVHIYVDEAADLEMAVKVVINAKTQRPSVCNAAESLIIHEKVGATFIPMLEAAISKVQQVEWRADEQAKALFSKAVLATEEDYAAEFLDYIMSVHLVSSLDEAISWINQYTSHHSEAIITANINAAERFQDLVDSAAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEALTSSKYLINGNGQIRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B2L2_SICCD
Sequence: WIMGHMVNGLEQVSEFLNLGANAIEFDIDFDQNGVAKITHHGIPCDCGRLCTKQTVFTEYLDNIRHVTTPGDPKFREQLILLALDLKLQRIPVEKAYAAGVDVATKLLDHYWQRGKSKARAYILLNLPLVQDYEFIRAFKDTLKNEGYEQHNDKVGVNFTGNEDLDETRKVLKKVGVDKHVWQADGITSCFARGTDRLTEALKRRDTPGYNYAYKVYAWTLVKYSTMRRLFRLGVDGVMSNFPDRVVEVLKEEEFADKFRMATYDDNPWKKFTG
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SdSicTox-betaIIB2ii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CTAA_BEII9
Sequence: MSALDTAPAGSLAETHAQRGTRAVAFWLWSLAVLVFLMVVLGGATRLTESGLSITEWKPISGALPPLSAEAWQAEFENYKRIPQYAALFPDMDLAGFKFIFFFEWSHRLLGRLIGVATALPLLFFWLRGRLPEGYRLKLLGLLALGGLQGFVGWWMVKSGLSDRVEVAQERLAIHLILASLTFCFIVWLAASLRKRPREISPSKASGLAWGAGLILLAILVQIGLGALVAGLRAGRAYNTWPLIEGNFLPPVESLTLLTPLWRNFVDNLLTVQFQHRMVAYLVLGLTLLQVFWTSGTLGSGRATKRAIALLGLVLAQVILGILTLVLVVPLWAGLLHQAFAMLVLGMAVAHLQALSQGR
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ERPA_BORPA
Sequence: MNAVTETVDLQAPPPVPLVFTDSAAAKVKDLLAEEGNPELKLRVFVQGGGCSGFQYGFTFDEVVNDDDTVLDKAGVQLLVDPMSFQYLVGAEIDYKEDLEGAQFVIRNPNASTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: HEPA_BHV1C
Sequence: MPVSHSNGCVCGVSLYSAWAAGPDRARVLLALLCRMDDGGCDAKFALVNVCARGVTALARGARDVTAARLEDLARAAAAPRALPLATLGHAATWKALYVSALAACARRLGPFAFIERRALEETTDTGLLVSAEEPPDAADAAPRAAVLRSALRLAVEEDAVRAAAAAAPAGGGSLARARLCAMRDGHADLSAPGNVVEFELTTKTARFYRIFADIAQPPRKRAGRLADVFAHREYRVRTEGSAAPVVVRALVPVNFDCVVADARAFSPMAAMLVFAQWHAALFTDGPAQVLGFLGPQLNPGGEERDYCFLLGFPGVPLVVSAADAGAVRDDLDAHVLTDGLWPAFGVHVYHALGPWNFLDGAAVASLNRRIAAARAALPPGGSDGSDWPAGRVSTILNSPARARGSGWPRFDFSAFFPTLYAHLVPENARLARAICARRDGRPGLKPSLLTFFGGLRHVHAPAYEAVIALANAVAAAVERAANARNFAVCTYVKDGFWGAFGDAAPEVVPREAALAAALALRDDCQRAAEAVLRAAGLHPAEGAELHLRFEGLFTHAVSWSANKYWLWDATAGGAEGELFVGFPCRTEFGRMAKRSLAGLLRRAVAQPERPSDTVAAAAAACDALVHAAFERRGDVRFWSATAPIADWGAVPRSALSGGDLLDADHGPRPYVLVAGHEAAPFPLPWGSLPLPVLLPDIACRAHMAPVLQELARMLNGALAALAAREGDDEPPIEEFEYNLADFDFLFA
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs.  The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
What are the official names of this protein?
DNA helicase/primase complex-associated protein, HEPA, Primase-associated factor.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HEPA family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RECR_PSEPG
Sequence: MSFSPLIRQLIDGLRILPGVGQKTAQRMALQLLERDRSGGLRLAQALTQAMEGVGHCRQCRTLTEQELCPQCADTRRDDTQLCVVEGPTDVYAVEQTGYRGRYFVLKGHLSPLDGLGPEAIGIPQLMARIEEQGTFTEVILATNPTVEGEATAHYIAQLLSEKGLAATRIAHGVPLGGELELVDGGTLAHAIAGRRPISL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: TIR_ECO57
Sequence: MPIGNLGHNPNVNNSIPPAPPLPSQTDGAGGRGQLINSTGPLGSRALFTPVRNSMADSGDNRASDVPGLPVNPMRLAASEITLNDGFEVLHDHGPLDTLNRQIGSSVFRVETQEDGKHIAVGQRNGVETSVVLSDQEYARLQSIDPEGKDKFVFTGGRGGAGHAMVTVASDITEARQRILELLEPKGTGESKGAGESKGVGELRESNSGAENTTETQTSTSTSSLRSDPKLWLALGTVATGLIGLAATGIVQALALTPEPDSPTTTDPDAAASATETATRDQLTKEAFQNPDNQKVNIDELGNAIPSGVLKDDVVANIEEQAKAAGEEAKQQAIENNAQAQKKYDEQQAKRQEELKVSSGAGYGLSGALILGGGIGVAVTAALHRKNQPVEQTTTTTTTTTTTSARTVENKPANNTPAQGNVDTPGSEDTMESRRSSMASTSSTFFDTSSIGTVQNPYADVKTSLHDSQVPTSNSNTSVQNMGNTDSVVYSTIQHPPRDTTDNGARLLGNPSAGIQSTYARLALSGGLRHDMGGLTGGSNSAVNTSNNPPAPGSHRFV
What is the function of this protein?
Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection.  The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface.  Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion.  In strain EDL933, acts via the effector protein EspF(U), in a phosphotyrosine- and NCK-independent manner.  Tir binds to host BAIAP2, which mediates association with EspF(U) and leads to stimulation of actin polymerization.
What are the official names of this protein?
Translocated intimin receptor Tir, Secreted effector protein Tir.
What is the protein family that this protein belongs to?
Belongs to the Tir receptor family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Secreted via the type III secretion system (TTSS). Released into the host cytoplasm via TTSS and then independently inserts into the plasma membrane from a cytoplasmic location. In host cells, localizes to the tip of the actin pedestal.
Protein: KTHY_BIFLO
Sequence: MNGLFVSFEGVDGVGKTTQVERLRAYLEAQGRTVVVTREPGGTALGKAIRQLLLHGVDGGAVDIAPRAEALLFAADRAQHVAETIRPALERGEVVITDRYLDSSLAYQAGGRELTPEEIRSLSMWATNNLLPDRTYLLDMDPALSHHRLEHAEDRMESAGDDFQSRTRQAFLDLAAAEPNRFRVIDASQSIEAVWAAIESDIKELA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: Y399_SIRV1
Sequence: MELERKSSGIIKSFNVLDIFSINLLYMGILSGISYPLFVSSLMKNVNLLFAIVIGAVFEIPLLLMYYKLTTKFPLNGGDYAYIRTAFSSKFYTIFGISLWLTYVLSQPILGDLVLLNFNIQNQFEQFLIVESLFPLVLLIIASKRIYAKIVDILAIFQIIIAIFIAFKSFNYQYQTFTISNTLLSALLFDLSAFIFINAISYIAGEIKNIKKSSMIGYFVSYGVVAILSILDSYSNLNILFALMPIWFFSYMPIANKIQSRLIQTMSFDKVLPEKFSKINPNVLLLIFSTETIANVLENLLGFNISFGLDGLLFIFWNFIIVAFAYLKLMNDKKLFSIVLTSLAIQIFLFFYLGYQNPIFYKFVIAGNIEYTILRIMILPIIGAIVYLLRKSKINVIPK
What is the function of this protein?
Putative amino acid transporter.
What are the official names of this protein?
Uncharacterized protein 399.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: ORF2P_HE71B
Sequence: MVTIKELLPYSYWIGHPVSNRAIVYLFVGFTPLTLETLHTLNYIILLNTKRWAPRSPHSDPARMRIPTQPRKAPL
What is the function of this protein?
Facilitates virus release from intestinal cells in vitro, possibly through the host autophagic pathway.
What are the official names of this protein?
ORF2p protein.
What are the subcellular locations of this protein?
Host cytoplasmic vesicle membrane; Single-pass membrane protein.