PharMolix/UniProtQA huggingface dataset:
Protein: AB10G_ARATH
Sequence: MELPVKAPIPGGREISYRLETKNLSYRIGGNTPKFSNLCGLLSEKEEKVILKDVSCDARSAEITAIAGPSGAGKTTLLEILAGKVSHGKVSGQVLVNGRPMDGPEYRRVSGFVPQEDALFPFLTVQETLTYSALLRLKTKRKDAAAKVKRLIQELGLEHVADSRIGQGSRSGISGGERRRVSIGVELVHDPNVILIDEPTSGLDSASALQVVTLLKDMTIKQGKTIVLTIHQPGFRILEQIDRIVLLSNGMVVQNGSVYSLHQKIKFSGHQIPRRVNVLEYAIDIAGSLEPIRTQSCREISCYGHSKTWKSCYISAGGELHQSDSHSNSVLEEVQILGQRSCKNIFRTKQLFTTRALQASIAGLILGSIYLNVGNQKKEAKVLRTGFFAFILTFLLSSTTEGLPIFLQDRRILMRETSRRAYRVLSYVLADTLIFIPFLLIISMLFATPVYWLVGLRRELDGFLYFSLVIWIVLLMSNSFVACFSALVPNFIMGTSVISGLMGSFFLFSGYFIAKDRIPVYWEFMHYLSLFKYPFECLMINEYRGDVFLKQQDLKESQKWSNLGIMASFIVGYRVLGFFILWYRCYRTRS
What are the official names of this protein?
ABC transporter G family member 10, ABC transporter ABCG.10, AtABCG10, Probable white-brown complex homolog protein 10, AtWBC10.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: A15_FOWPN
Sequence: MYIENNSLVLIIPETNSITPQLFTIHDNKPICVCSRYSLIPSKKENVQISYIDNIHMYFRSFKNLYLVNPRNHDIIKVFNFLKNYKWGGNFYLLFNV
What is the function of this protein?
Late protein which is a part of a large complex required for early virion morphogenesis.  This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions.  A15 is required for the stability and kinase activity of F10 (By similarity).
What are the official names of this protein?
Core protein A15 homolog.
What is the protein family that this protein belongs to?
Belongs to the chordopoxvirinae A15 family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion. Note=Localizes in cytoplasmic virus factories and present in the virion core.
Protein: CMOA_PSEPK
Sequence: MSKQPDRLFSQPLEQVPDFVFNEDVVRVFPDMIKRSVPGYPTIVENLGVLAARFAQPGTALYDLGASLGAVTQSLRRHVRSDGCRVIAVDNSAAMVERCRQYLTAQDSMFQELLPVQVLEADILALPFEPASVVAMNFTLQFIAPDQRLELLGRIRQALLPGGALILSEKLRFADEQEQDLLNELHLDFKRANGYSELEIAQKRSAIENVMKPDTLETHQERLRAAGFSKVVPWFQCLNFASLIALP
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: HEMH_FRATW
Sequence: MQQYSSKYNKQAILLVNLGTPDNYDTKSIKRYLKEFLSDPRVIEANPVLWKIILNLIILPIRAKKNVHTYKTVWNKQHNKSPLLFYTENLADKLDKKLDNYIVDYAMRYGNPSIESKIKSLQDQGATEIIIFPLYPQYSATTTATVYDEVYRVLSKLRWQPTIKGINPYYDNKFHIQTISQQIKEHLKKLDSTPDTVLFSFHGLPKEYFDKGDPYYCHCYKTYRLVKEELQNEYPNIDFELSFQSRFGPKKWLEPYTTVKLEEFAKQNKSVVVIAPGFSADCLETLEELAISEKENFIKKGGKEFSLIPCLNDSNQHVDMLYNIIDEEICLKK
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_OCEIH
Sequence: MKHSLHKIIERQDLSTEEIKEVFKHCFSQEVSDSELAAILISLKMKGETAEEVAGLSQVIQEHSPFLLNFHQPVMDNCGTGGDRSNSFNISTCSAFVLAGAGVTVAKHGNRSVSSQTGSADVLEKLGVSLAFTKEQVNEMLDKNQIAFLFAQHVHPTLKQVGKVRKDLRIPTIFNFIGPLTNPVHLDSQYIGVYDPEALQMVAKAAQLLGRERAIVIHGAGGLDEASLQGENKYILVENDRLEEKTIHPEEVGLSVYPNDEIQGGNATENANILLSVLKGEDSAYLDTVLFNAGIALFASKKADSIYDGVELARESITSGSALSKLNNLITFSKKVSEVV
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: Y1394_METTH
Sequence: MRNFLDKIGEEALVVEDEVSTSFEAASILREHPRDLVILKNLKESDIPVISGLCNTREKIALSLNCRVHEITHRIVEAMENPTPISSVGGLDGYRSGRADLSELPILRHYRRDGGPYITAGVIFARDPDTGVRNASIHRMMVIGDDRLAVRIVPRHLYTYLQKAEERGEDLEIAIAIGMDPATLLATTTSIPIDADEMEVANTFHEGELELVRCEGVDMEVPPAEIILEGRILCGVREREGPFVDLTDTYDVVRDEPVISLERMHIRKDAMYHAILPAGFEHRLLQGLPQEPRIYRAVKNTVPTVRNVVLTEGGCCWLHAAVSIKKQTEGDGKNVIMAALAAHPSLKHVVVVDEDIDVLDPEEIEYAIATRVKGDDDILIVPGARGSSLDPAALPDGTTTKVGVDATAPLASAEKFQRVSRSE
What are the official names of this protein?
Uncharacterized protein MTH_1394, ORF-B(T).
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
Protein: DSRB_SHIBS
Sequence: MKVNDRVTVKTDGGPRRPGVVLAVEEFSEGTMYLVSLEDYPLGIWFFNEAGHQDGIFVEKAE
What are the official names of this protein?
Protein DsrB.
What is the protein family that this protein belongs to?
Belongs to the DsrB family.
Protein: RL18_PARL1
Sequence: MSNMKTLSQRRAMRNRAKLAKASVVRPRLSVFRSSKHIYAQVIDDTRGVTVAAASSLDEKFGKKAGTDVAAAGEVGKLLAQRAKDAGITDVVFDRGGYIYHGRVKALAEGAREGGLNF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: DER_RICAH
Sequence: MTKKIIALVGRPNVGKSTLFNRLSIRKKAIVHDLPGITRDRKYTDGKIGSFEFLLIDTPGLEENHDSMGARLMEQTTKAILEADLICFMVDGRSGILPNDKLLGSFVRKYNKPAILVVNKCEKAFDFDKEYYKLGFDSMVTISAEHGTGLIDLYDEIITKLPEEESIETNIADPIKGDYLQIVVSGRPNAGKSTFINALINDERLLTGPEAGITRESIEIDWHYKNNHIKLIDTAGLRKKSTITESLEKLSASDAINSIKFANTVILMIDALAPLKQQDLNIASHVVNEGRGIVIVVNKWDLVKESKKEAFQEEFYYQINTHLPQVKGVPVLFISAINKQNIEQVLDSCLKIYKIWNKKIATSKLNEWLNFTTEAHPLPLQKGGRRVRVKYMTQTKTRPPTFKLFSNNPEKITDSYTRYLVNNMRDAFDMPGIPIRFTYVKTKNPYV
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: TSN11_RAT
Sequence: MAHCKTEQDDWLLAHLKYLLFIFNFFFWVGGAAVMAVGIWTLVEKSVYLSILASSTFAASAYVLIFVGGLVMTTGFLGFGAIIREQKSCLSTYFCLLLAIFLVELVAGVLAHVYYQRLSDELKRHLHSTLTEHYGQPGAAEITASVDRLQQDFKCCGSNSSADWQHSVYILSQEAIGRQVPDSCCKTVVARCGQRAHPSNIYKVEGGCMAKLEQFLADHLLLMGAVGIGVACLQICGMVLTCCLHRRLQQHFY
What are the official names of this protein?
Tetraspanin-11, Tspan-11.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KU70_ASPOR
Sequence: MADEDQYRGDDQIDEEEEETDESGYKTVKDAVLFAIEVSDSMLTPRPSSDSKKPAEESPTTAALKCAYYLMQQRIISNPRDMIGVLLYGTQASKFYDEDENSRGDLSYPHCYLFTDLDVPSAQEVKNLRALAQDGDESKDVLKASGERVSMANVLFCANQIFTSKAPNFLSRRLFIVTDNDDPHGDNKSLRSASTVRAKDLYDLGVTIELFPISRPGHEFDTARFYDDIIYKASPSDPDAPAYLQTDSKASPATGDGISLLNTLLSNINSRSVPRRAQFSNIPLELGPNLKISVSGYLLFKRQAPARNSFIWLGGEQPQIVKGVTTQIADDTARTIEKWEIKKAYKFGGDQVAFTPEEMKSLRNFGDPVIRIIGFKPLSALPFWANIKHPSFIYPSEEDFVGSTRVFSALHQTLLRDKKAALVWFIARKNASPVLGAMVAGEEKLDESGVQKFPPGMWIIPLPFADDVRQNPETTLHVAPEPLIDQMRYIVQQLQLPKASYDPFKYPNPSLQWHYRILQALALDEDLPEKPEDKTLPRYRQIDKRTGDYVLSWADELEKQYAKISAHGPKSTLVKRSAKDRTSEVEDAAQKPYKKVKVETDEQGVEDVVRAHYQKGSLSKLTVPVLKDFLNAHGRSAAGKKADLVERVEEYLEQK
What is the function of this protein?
Single-stranded DNA-dependent ATP-dependent helicase.  Involved in non-homologous end joining (NHEJ) DNA double strand break repair.  DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA.  Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection.  Required also for telomere recombination to repair telomeric ends in the absence of telomerase.  ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase.  Involved in telomere maintenance.  Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement.  Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere.  Required for mating-type switching (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit Ku70.
What is the protein family that this protein belongs to?
Belongs to the ku70 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RHG17_MOUSE
Sequence: MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHHSHKRLIACFQGQHGTDAERRHKKLPLTALAQNMQEASAQLEESLLGKMLETCGDAENQLALELSQHEVFVEKEIMDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFSLYEEWTQVASVQDQDKKLQYLWTTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAKQEGTLAEIAAATSVHVVAVIEPIIQHADWFFPGEVEFNVSEAFVPLATPNSNHSSHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHIAPAFQPPLPPTDGNALAPAGPEPPSQSSRADSSSGGGPVFSSTGILEQGLSPGDSSPPKPKDSVSAAVPAAGRNSNQMTTVPNQAQTGGNSHQLSVSTPHSAAGPSPHTLRRAVKKPAPAPPKPGNLPPGHPGGQSSPGTGTSPKPSARSPSPPQQQQQQQQQQQQQQQQQTPGMRRCSSSLPPIQAPSHPPPQPPTQPRLGEQGPEPGPTPPQTPTPPSTPPLAKQNPSQSETTQLHGTLPRPRPVPKPRNRPSVPPPPHPPGTHTVDGGLTSSVPTASRIVTDTNSRVSESLRSIFPEIHSDLASKEVPGHILLDIDNDTESTAL
What is the function of this protein?
Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells.  Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state.  The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere.  Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments.  Acts as a GTPase activator in vitro for RAC1 (By similarity).
What are the official names of this protein?
Rho GTPase-activating protein 17, Neuron-associated developmentally-regulated protein, Nadrin, Rho-type GTPase-activating protein 17.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.
Protein: YITH_BACSU
Sequence: MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRFFGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIRLCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLAAFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQIITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYALISQALG
What are the official names of this protein?
Uncharacterized N-acetyltransferase YitH.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: CDC27_CAEEL
Sequence: MKESAASVAVRPQLREVFERFPADAHRTIEDEIHEMMKCYAFDDAIFLAELHYETDKSNNSESLLLYADCLYRANKKEECYGLLSSVKLSGARLFYLLARVSYDLNKIDDCRGALFEHDDGVIRKDILEEPRVASHANLLHAQMLCDESYMDLALESCQKSLDENILLWSAIITYLRFGGHDLAHTFEKHHRKSNGLYLDSPASSLKSETPSPNVPGPSSSSAASTAEPSRLESSVRRSTRGTIASANRETRNTTSNITPRQSTPGSTPSRINPTAPRKSSRISEMTTRRTESSVTGSRSSLFTEPERPHTRATHSSRNRANAALNSDTENSNASNTRTRSGIASVTRGSSSSQRTNPVRTSIRIADAAAAANKTAKTLSQRRRNEKQPLVSRNSNLARSLSGSTNSVASTASERPSEDEVSQINPPLPSVASSLNNDEPMDIVDGVYDPEYKKLFDVYQHIALIEESISTYNWRSADALFAKLDRDIILNTSMVRLQLGRACFEQSEYRECRNILDDLHKRRKWKVDGTELLSTSMWHLQDTHALSALSQILTTESRERPQSWCAAGNCFSLQRQHTQAIECMERAIQLDKRFAYAYTLLGHELIVQDELDKAAGSFRSALLLSPRDYRAWYGLGLVHLKKEQNLTALTNIQKAVNINPTNRAMLCTLSQIEQQRGQIDTALVLIDRALTLNPLDVACRFNRSRLLFEANRNEECLVELDKLKASSPDEAFIFHLLARVHRRMGNTHLALLNYSWAAELDPRGEQNITDSNVINREEYEDDEYGSPV
What is the function of this protein?
Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity).  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity).  Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:12620985, PubMed:11134076).  Required for embryonic anterior-posterior axis formation (PubMed:11832245).  Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870).
What are the official names of this protein?
Cell division cycle protein 27 homolog, Anaphase-promoting complex subunit 3, Metaphase-to-anaphase transition defect protein 1.
What is the protein family that this protein belongs to?
Belongs to the APC3/CDC27 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCY8_CAEEL
Sequence: MRTKKAFLLLTFNVLIYLAACQETERILANNGTEDNEITTSKGVSPNTNPLFLSNSTAGLYDSKGRIRLTIGHIGAIGALRNDVKILEVSHKALQAEGILDDDLDVEIISQTGCGESYEGVAVAADMYHLQKVKAFIGPYCNAEMDAVARMAAFWNIPIIGYMAASNNLADKNAYPTLARISLRTTNSIAEATCAMLRHYGWNKVAIITNTGILAYDRVLSFEEVFHQRGINVVKKIMFDEFADSKAMIASGLLNDIKNSARIVVCLFSNTRESSREFLTAANTQGMNVNEYGYVFPWLQDGGKDASPWTGADGSMLQKVKDQYANAIIIDDVNSFDNTIVGPFIERIKDVGLTEADVDIANIYGYLYLFDALKLYAIAARKVLNETGKAENLLNGRMMWQNMRKLKFVGMVGASGIASGQVSMDDRAERAPLYRGFFVSPNSDSVLPMVHMEPTMLDNCDGIANKSGCYEIVVTDIMRDFWPSVDRKMPKDEPDCGYRNERCDYTLIIIGAALILLFIVAAVSAFFAQKILEKRALDKLPFRIYRDDLQFIDEEQLKSMLSLGSTRTKMSNMNYGSRNHAIVGTNTHAIYHKYVQRRPIVFNRADKTLIQLMKAAVHDNINPFLGMVWNEREEMLLVWKFCSRGTLQDIIYNESIQLDTKFHGAFIRDILAGLEYLHASQIGYHGSLTPWSCLIDRNWMIKLTDYGIADPLERWEKSQSISRDGLTSDDDKSQATQATSILYESPEMLKNREKNRVRRVDQDWMRQTQTRRQLGDVYAFGLVMYEIIFRALPFPEGTNQSELVEWLRDGSKVVKPTIPQNKVLNMDLSALIQDCWNTTPEMRPSLRRIKLNVETYLNIKGSLVDQMTRMMEQYANNLEKLVAERTGMLEEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNASPLEVVAVLNGIFDGFDQFIARKDAYKVETIGDAYMVVSGVPEENGHRHINEIASIALDVHKFLSEFIVPHKRDTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVNMASRMESNSEPGKTQISETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLMGTKSEGSGRSGAYLAPSMKSAGTGFTGMLGNSANDYSLNLKNPTGLQR
What is the function of this protein?
Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:27062922).  Regulates thermotaxis responses in AFD sensory neurons (PubMed:16415369, PubMed:21315599, PubMed:27062922).  May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369, PubMed:21315599).  Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3 (PubMed:27062922).  cGMP levels antagonize the actin cytoskeleton regulator wsp-1 (PubMed:27062922).
What are the official names of this protein?
Receptor-type guanylate cyclase gcy-8.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, cilium. Note=Localizes exclusively to the sensory ending, known as cilium, in AFD neurons.
Protein: JPH4_RAT
Sequence: MHVPLGRKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSHQPWRAPPCRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEPVTTPVLRGLSSRGPDAGCLTEEFEEPAATERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT
What is the function of this protein?
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells.  Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.  JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity).
What are the official names of this protein?
Junctophilin-4, JP-4, Junctophilin-like 1 protein.
What is the protein family that this protein belongs to?
Belongs to the junctophilin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N- terminal part associates with the plasma membrane (By similarity).
Protein: MSHA_GORB4
Sequence: MTTGPLPRRVALISVHTSPLAQPGTGDAGGMNVYVWQTATRLARRGVEVEIFTRATSSSDAPRVAAAPRVTVRNVVAGPFEGLDKRDLPAQLCAFTAGVLRAEAAQEPGYYDLIHSHYWLSGQVGWLARDRWGVPLVHTAHTLAAVKNASLAAGDTAEPQLRVIGEQQVVDEADRLIANTETEASELISMYGADPARIDVVTPGADLDCYTPGPREMARTSLGLDQNEAIVTFVGRIQPLKAPDLLIEAAAPLIRRSRTSRRPVRVLIVGGPSGSGLDRPTALIDLAHDLGIADAVTFLPPQAPARLADVYRASNLVAVPSHSESFGLVAIEAQACGTPVLAADVGGLSVAVAGGRTGVLVGSHAVGDWTNALEKALAQPDRLAEMGRNARVHAEQFSWDHTVDAMLSSYSRAMQSFAARNPDAAQSVAAQNVTGSSSRTRRPWRRRRSTLLPMTGRS
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: SELU_ECODH
Sequence: MQERHTEQDYRALLIADTPIIDVRAPIEFEHGAMPAAINLPLMNNDERAAVGTCYKQQGSDAALALGHKLVAGEIRQQRMDAWRAACLQNPQGILCCARGGQRSHIVQSWLHAAGIDYPLVEGGYKALRQTAIQATIELAQKPIVLIGGCTGSGKTLLVQQQPNGVDLEGLARHRGSAFGRTLQPQLSQASFENLLAAEMLKTDARQNLRLWVLEDESRMIGSNHLPECLRERMTQAAIAVVEDPFEIRLERLNEEYFLRMHHDFTHAYGDEQGWQEYCEYLHHGLSAIKRRLGLQRYNELAARLDAALTTQLTTGSTDGHLAWLVPLLEEYYDPMYRYQLEKKAEKVVFRGEWAEVAEWVKAR
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: SYY_HELPJ
Sequence: MEQKISVALKEIKRGANEIIGLEYIEKLVRKYYETNERFIVKAGFDPTAPDLHLGHTVLIQKLALLQQYGARVKFLIGDFTAMIGDPTGKNETRKPLNREQVLENAKTYKEQIYKILDQKHTEVCFNSAWLDALGAKGMIELCAKFSVARMLERDDFAKRYKENRPISIVEFLYPLLQGYDSVAMGADIELGGNDQKFNLLVGRFLQRAYGLNKEQSIITMPLLEGLDGVQKMSKSLGNYVGITEEPNAMFGKIMSVSDDLMWRYYTLLSAKTLEEIEDLKHGILHQTLHPKAVKEDLASEIVARYYDNDQAFKAKEQFSKVFSANLLPEILLESDFDEGVGVLDVLKQIGFCPSTSQARRDIQGGGVKINQEVVKDESYRFVKGNYVIQLGKKRFMKLNIN
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXN3_HUMAN
Sequence: MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN
What is the function of this protein?
Acts as a transcriptional repressor.  May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
What are the official names of this protein?
Forkhead box protein N3, Checkpoint suppressor 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: CWC15_ASHGO
Sequence: MTTSHRPQLEARSGTKSGVAGEYVPTGVKHARLLPGHRTVKRRREGGATAEDEERERAGAETRTVDCNEGTDELAGEGRSAGSGDGDEASSAEDSSDADDEDDVDNPEELRRELEALRASKTGAKTGAKTGAKTGEKGAGGGGWRAGAVFGRQKRRREQAEGRAYRNDVTQSEYHQDFLRRLTK
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC15.
What is the protein family that this protein belongs to?
Belongs to the CWC15 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS16_BRASB
Sequence: MSVVIRLARAGTKKRPVYHVVVADSRFPRDGRFIERLGYFNPLMPKDNEARLKLDMEKVKGWLAKGAQPSDRVARFLDAAGVKKREARQNPIKAVPRKERKAQAEAAAKG
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: PGK_YERPE
Sequence: MSVIKMTDLDLAGKRVLIRADLNVPVKEGKVTSDARIRASLPTIEAALKQGAKVMVTSHLGRPTEGEYNEEFSLLPVVNYLKEKLSSPVRLAKDYLDGVEIAAGELVVLENVRFNKGEKKDDEALSKKYAALCDVYVMDAFGTAHRAQASTHGVGKFAPIACAGPLLSAELEALGKALGNPARPMVAIVGGSKVSTKLTVLGALSKIADKLIVGGGIANTFVAAQGHNVGKSLYEADLIPEAKRLLETCDIPVPTDVRVATEFSETAAATLKPANEIKDDEQILDLGDESAERLAEILKNAKTILWNGPVGVFEFPNFRKGTEIVARAIAESEAFSIAGGGDTLAAIDLFGIADQISYISTGGGAFLEFVEGKKLPAVVMLEERAKQ
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHOSP_SYNV
Sequence: MAGIYAVSIKGHASAIFNRQEKEISTGRVWEVMKKIMSLKPTRVIMSYSLLRSALDKSRQLTQEEYNIMQLILDGCVKTLEPVAASGICIDVNLGKCTKHTIPFGITNNDVGHVSVVMTLPFLEEGCYNIGACFDGRLSKSRSDASHYAVDVSLEIYLKSLSRDEAEEQISKGTSVYPFKINHPTYFEDETDTSDGESLSGRASSDDGPEDGGHGHGDKNNEKNSGKVVRKRKSRKEIDVGRFKMVKDNIINTRSGLLKSMRGTGHRKHRTQEITEGYNYGDKDAE
What is the function of this protein?
This protein is probably a component of the active polymerase.  It may function in template binding.
What are the official names of this protein?
Phosphoprotein, Protein P, Protein M1.
Protein: ELP4_SCHPO
Sequence: MSFKRKAAPQIAPTNLPTGVRLSSKDARWITSSGSSSFDYYLSGGIPMKSLLVIEEDSMDYASVLLKFFAAEGLKQDHVIWLGPSIGEMWFRQLPGDSDRPNKNENSAGEDNHSSPPSKNPQQERMKIAWRYEQVSKTKAPTLDMIPPGYTHSFDLSKNLIVKSDMKYAVSPFPLETGSNPYAPVIESLTRFLSTLTPGTVCRLVLPSILSPAFYSIRATHPQHFIRFIHTLSSLIKCTTSVHLICMCSVPSTLFSRDCEQIFWLENLASAVFSLHPFPVKETVNGLVTQPLGLFRIHKLPLALPFTNHANSNEAGDLSFTVSKRRFTIEPWVLPPLDDEQKDTKISNTNPQKQPVKSLDF
What is the function of this protein?
Component of the elongator complex, a multiprotein complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:22768388).  The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).
What are the official names of this protein?
Elongator complex protein 4.
What is the protein family that this protein belongs to?
Belongs to the ELP4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.