PharMolix/UniProtQA huggingface dataset:
Protein: Y3709_CLOAB
Sequence: MSSKGFEIGEEIKEQNFFIDNRLDASQLFFVIYLLGEKLHTISLSEERPSIRYEGSLFGVIGGTLFINGTTVTTGYSKVGELEVLVVSPQTAETMFFLINKEDYFVLGSDTIASIQTQGNAQVVIHEDTFIIDDNEEFVYFNNAPIKGHHYVKGVQIGDQILTHDFLLEKRKEQWKLTTFSETVVFNQESFLRQLPAVEFPKDFPKYRRSPRLRLEPPSDKFKIQKIGEAQKPSKNGILRAIVPPLGMLAATGVTSVLSGRNPIMMLGMGSMSVITATFTVSQYISEKKEHKIEDQKRKEDYEQYLIKAVAEISDKYDEETEVLHFRNPSPEKLAEMIETYNSRIYERMASDKDFLVVTLGTGNQASNLSVDSDINDRDNDEKSLRVKHLVEHFSTQREVPITLNLSTQTLGLVGTYPVLKTAVANLLLQVAFFHSYRDVNFLSLVPEKSYRKDWIQWRLLPHFKIQELNMRGIVHNAHTRDLLLNSFYQILNKRKQVLKDAGKEKPKFVPHYIFTIFDDSYLSGHGINEFLAEDMSELGVTVIWCKEDQKLLTETVTALVEYKNQSAGEIINDNKIYVAKSFEPYGDVPLLEKSLRKLTNLEHVEVEKNAIPESLSLLDQYEVKKVEELDIQERWASAEPNKSIKSLIGWRGKSEYMYWDLHERVHGPHALVGGTTGSGKSEFLTTYLIGLAINFSPEDIGMLIIDWKGGGIANTLDKLPHFMGSITNLDGAGTARALASIKAEMDKRMKEFAKFGVNNINGYMSLYKSRLNPKPDTKYPEKPIPHLILVSDEFAELKSNVPEFLDELTSVARIGRSLGVHLILATQKPSGVVNDQIEANSTSKIALKMASEQDSNELLKTHDAAHITQPGRGYIKVGENEVYELFQSGYAGVPYDPDDTTVETVDERIYQINGIGQTELVYDPGEEVVQGHDTSDLPTQLEAVISEVNRVFEASNLTLPAKPWLPNLESKIPTPEVTQTAELNTKIPLGLLDIPSKQTQENYTFDITDSSHTAIFSSPGYGKSTVLQTIVMNLARQNTPEQIQFNLIDFGNNGLLPLKELPHVADIVMLEEVEKLQKMMERISSILFYRKSLFKKVGVASLSQYEAKTKEKLPIIITILDSYDGLGQQDRRKEDIDNLLIQLLREGAALGLYLIMTVGRVGAVRMSMMSNIKTKMVLYLNDESEVVAVMGRERVTQEEIVGRGQVMLDIPTAIQFYLPTHDGNDVKLLEAIENDVIKMDKAWTGKRPKKIPMTPEELSLEIFEEYSEVMQWQREQKIPMGMSYQTTEILGIVPSAQPYFLFAPMDDDQMLLFQALLLKQIAKIKTGVLLVDFNESFEEVLAHHSLTENVTLITDKNDAKDVIAGMVGYVKLAKKHENGEPMLLVISNLQDFIQKTNLPASDFVLALKNVYKAGLDVLIFAPHEYIAKSFDEVPKAIRQLKFTGMIGSRAYDTPLIKGTSSSREPELSIQDAYFVLRGGSSFDKMKLPELTKGENND
What are the official names of this protein?
Ftsk domain-containing protein CA_C3709.
Protein: SYA_BURTA
Sequence: MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRATTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTTVYKLPADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGARYASDNFWQMGDTGPCGPCSEIFYDHGPGVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERIAAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKLGRKGPFFHKLVADLVAEMGAAYPELKEAEQRVTDVLRQEEERFFETIEHGMSILEAALADLDAAGGKTLDGELAFKLHDTYGFPLDLTADVCRERGVTVDEPAFDDAMARQREQARAAGKFKATQGLEYTGAKTTFHGYEEIAFDDAKVVALYVEGASVGEVKAGESAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVADTLKVQADVIGHHGELEQGVLKVGDAVRAEIDAARRARTARNHSATHLMHKALRDVLGSHVQQKGSLVDADKTRFDFAHNAPLTDDEIRRVEAIVNEQVLANAPGIVRVMPYDDAVKGGAMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGLFKIVAEGGVAAGIRRVEAITGDNAVRYVQALDARVNAAAAALKAQPSELIQRIGQVQDQVKSLEKELGALKSKLASSQGDELAQQAVEVGGVHVLAATLDGADAKTLRETVDKLKDKLKSAAIVLAAVDGGKVSLIAGVTADASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPANLPAALAGVKGWVEERL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SHEFN
Sequence: MSKRDYYEVLGVGRDTSEREIKKAYKRLAMKFHPDRNPGDKAAEASFKEIKEAYEILTDSDKKAAYDQFGHAGVDPNRGGHGGGQGDFGDIFGDVFGDIFGGGRRGGGQRQAARGSDLRYNLELSLEEAVRGLTKELRIPTLAACDLCDGSGAKKGTSATTCGTCHGQGQVQMRQGFFAVQQACPTCHGRGKIIKDPCGKCHGEGRVEKSKTLSVKIPAGVDTGDRIRLTGEGEAGEFGAPPGDLYVQVSVREHAIFTRDANNLYCEVPISFSKAALGGEIEVPTLDGKVSLKIPTETQTGRMFRLRGKGVKSVRSHAVGDLLCKVVMETPVNLNEKQKELLREFEATLTGESKKHSPKAEGFFDGVKKFFQDLNS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1570_EDWI9
Sequence: MSSEEALARLAAEEQQLQFTLFNPDTAWQLGCALRQEAGRRGLHVTIDIQFAGQTLFHCAMPGTSPDNAEWIRRKRNVVLRFQRSSYAMGMRLTLRNTTLEAFYGLDPADYASQGGSFPLRIVNCGCVGAISVSGAPQLDDHLLVSEVIARFLGINQ
What are the official names of this protein?
UPF0303 protein NT01EI_1570.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: BFSP2_RAT
Sequence: MSERRVAMDLPSGSNASMPLQRHRVSSLRGTRSPSSLDSPPASRTSAVGSLVRAPGVYVGVAPSGGIGGLGARVTRRALGISSVFLQGLRSSGLATAPAPGPERNHATAEDLGGCLVEYMTKVHALEQVSQELETQLRAHLESKAKRSGGWDALRASWASSYQQVGEAVLENARLMLQMETIQAGADDFKERYENEQPFRKAAEEEVSSLYKVIDEANLTKTDLEHQIESLKEELGSLSRSYEEDVKVLYKQLAGSELEQTDVPMGTGLDDVLETIRVQWERDVEKNRAEAGAVLQAKQQTEVVHVSQTQEEKLAAALSVELHDTSRQVQSLQAETESLRALKRGLENTLHDAKHWHDMELQNLGAVVGRLEAELAEIHSETEQQQQERAHLLACKGQLQKDVASYHALLDREESN
What is the function of this protein?
Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity).  Plays a role in maintenance of retinal lens optical clarity (By similarity).
What are the official names of this protein?
Phakinin, 49 kDa cytoskeletal protein, Beaded filament structural protein 2, Lens fiber cell beaded filament protein CP 47, CP47, Lens fiber cell beaded filament protein CP 49, CP49, Lens intermediate filament-like light, LIFL-L.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed primarily at the plasma membrane in peripheral lens fiber cells, however also localizes to the cytoplasm in mature lens fiber cells.
Protein: DPPRS_CORGL
Sequence: MSEHAAEHHRDTQNFLTSEPHTTAIEDNKKRQPPKNLADGMIKALRPKQWVKNVLVLAAPLAAGADAIFNQRTIIDVAIAFVVFCFGASAIYLVNDARDVEADREHPTKRFRPIAAGVLPVGMAYGMAVALIALSIGLSFLATDGVALACVIGVYIALQLGYCFGWKHMPVIDIALVSSGFMLRAMAGGVAAGIELSQWFLLVAAFGSLFMASGKRYAEILLHERTGAKIRKSLESYTPTYLRFVWTMAATAVVMSYALWGFDLSQHSTDAGPWYQISMVPFTIAILRYAAGVDTGDGGAPDEVALSDKVLQVLALAWVFCIVMAVYIMPMF
What is the function of this protein?
Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis.  Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR).
What are the official names of this protein?
Decaprenyl-phosphate phosphoribosyltransferase, 5-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase, DPPR synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: SCA4_RICTY
Sequence: MSKNDNQDISEFDPLNREFTEAEKQQQMQQEQEFFSQSILDIVDDGFIVASSSQSTPSISVLSNSLPHGDQKSDPITEAIRKEILEKQRDILREYLANTNPELAAQIAKEEDDKKFRAFLSNQDNYALINKAFEDPETKKNLEEVEIVGYRNILSTYSAASGYPGGFQPVQWENQVSASDLRSTVVKNDAGEELCTLNETTIKTNSLIVAKQDGTQVQINSYREIDFPIKLDKADGSMHLSMVALKADGTKPAKDKAVYFTAHYEEGPNGKPQLKEISSPQPLKFVGTGDDAVAYIEHGGEIYTLAVTRGKYKAMMKEVALNNGQSVDLSQTIAEDLTKVQGPSHVRHTPIITPNQELELSIETHSNQQVPPITTFNKPLQPEISQTHQLQPQQAQSSGIPNLVLNAAHALSISMQDLLHNINASLTQKQDINKQSDLIKEAANTILNNKKSDFAEKQYNIIALTENTLSNKDIIADAKVNVVSALLETIQNDQNTLDIQKSKILEATVAITLNSENIELKQKQQILEKVVDVSLSIKDDISRAVAIDSITDAVIKSNIANKDKEQIFMTIFDQVNSYEFSNITKQKLLGSMLKKAVETKVISPEQQQLIHQNLDKITTEHTKRDTIEKVNNILLDPFSNTVLKTTNIQVITANVLDSPVPVEIKSELIQVVTQKVAESALEPKDKTEIVKGIGKIIATHSDTSLPLYDKGVIMESVAKGIVESKTDLRERELITEGLVNGIYEVKGDKAVVHAISSVIANSNINQSEKEVLKKSQDIVSERVLDKEIQNLDGELKEKNIEESKLRDDIYNKTQDVANELNIKTFLDDNHGKREVSEEVPKNTSSLLNDISQRTIEKVNNLRAMLSQDANLKTFEEKKDESTKKVDELVKAFDNKSSTEEQQNFIKSHLIDNKTLSREVRLQIIDNLLKAQAQKRAETIENLSAKTEDVRVVSGKSELEPISKDEPYIQKAKMVVERDRVGIKDNIKIMGALINARDSIQSENLNKSTHIKKESSVPQR
What are the official names of this protein?
Antigenic heat-stable 120 kDa protein, 120 kDa antigen, Protein PS 120, PS120.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TS15B_SOLHA
Sequence: MRRSDNHHPTVWGDHFLAYANLSGANEWEEKEHEDQKGEVRKMLVLSPSKSLQKLELINTIQLLGVSYHFEHEIEESLSEIYNGYEEWIGKSHDLHVVALSFRLLRQQGYYVSSDVFRKFTDDQGNYNKALVNDTHGLLSLYEAAQFRVHDEEILDEAINFTTTHLNLLLPKLSNSLSMQVSYALKYPINKTMARAATRKYISFYQEEKSSCDQLLINFAKLDFNILQKMYKREMCDITRWWKELDLVNELGFARDRVVELYFWSLGVYFEPQYKVARNILTKVLCFVSITDDIYDTYGTLHELTLLTNAIERRNIDAIENLTSYMKLFYTALLHFYDEVEKELEKENKSFRVNFAISEMKKLVRAYFQEAKWYHGNTVPKMEEEYMKNGIQSSASPTLATASWLGMGDEATKEAFEWISTEPPILVASSNIARLLNDIVSHEREIERGDVASSIECYMKEYGATKEEAYMEIRKIIENNWKDLNRGCLKPTTVPRVLLMPVLNLTRVAEFVYKDEDAYTFSKNNLKDVIFMVLDDPIEE
What is the function of this protein?
Sesquiterpene synthase involved in the biosynthesis of volatile compounds (PubMed:21818683).  Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into germacrene A (PubMed:21818683).
What are the official names of this protein?
Sesquiterpene synthase 15b, ShTPS15b, Germacrene A synthase TPS15b.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
Protein: COAD_YERPP
Sequence: MITKAIYPGTFDPITNGHLDLVTRASAMFSHVILAIADSSSKKPMFTLDERVALAKKVTAPLKNVEVLGFSELMAEFAKKHNANILVRGLRSVSDFEYEWQLANMNRHLMPKLESVFLIPSEKWSFISSSLVKEVARHGGDITPFLPKPVTKALLAKLA
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGB_STRPI
Sequence: MKVIKVENQVQGGKVAFEILKEKLANGAQTLGLATGSSPLEFYKEIVESDLDFSNLTSVNLDEYVGLDGDNPQSYRYFMQENLFNQKPFKESFLPRGVKDNAEAEVERYNQILADHPVDLQILGIGRNGHIGFNEPGTPFDSQTHLVELDQSTIEANARFFAKIEDVPTQAISMGIKNILDAKSIILFAYGESKAEAIAGTVSGPVTENLPASSLQNHPDVTIIADAEALSLLEK
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: MKNK2_XENTR
Sequence: MVQKKTTEMKGFHRSFKGQNPFDAAYEMESRNMASVFNFDCPSRPDVPSSAPIDIPDAKKRTKKKKRCRATDSFTGRFEDMYQLQQEILGEGAYAKVQSCINLITNKEYAVKIIEKRPGHSRSRVFREVEMLYQCQGHSNVLELIEFFEEEDKFYLVFEKMCGGSILNHIHRRRHFNEREASFVVRDIAEALNYLHNKGIAHRDLKPENILCESPHQVSPVKICDFDLGSGIKLNSDCSPISTPELLTPCGSAEYMAPEVVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPPFVGHCGSDCGWDRGEACPACQNMLFVSIQEGKYEFPEKDWAHISSGAKDLISKLLLRDAKKRLSAAQVLQHPWVQGNAPDNTLPTPIILQRNSSAKDLTSFAAEAIAMNRQLMEREEEEEGTESSSSCPIVVKATSCSMQLSPPSESKLAKRRHGSKGGISPPSLAPLLIVSD
What is the function of this protein?
May play a role in the response to environmental stress and cytokines.  Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).
What are the official names of this protein?
MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Protein: FBSP1_BRUMA
Sequence: MFTEGDKFNQTVVETDLEQAVDVACRNAQDCCHSKSFTCFTRRMRAVSAARLPHVVLLAVFEYLNLKDLARCMRVCKHWLTVLQYPDSFVWRRLARTVIPDEALNDFSLLSEIPSFKDKLRAFCYAWNPNDSSKNNYLRPNGFTVHRNPVAQSTDSVRGKIGVNSGIHAWEFTWEGPLGTVACIGLATKHAALHCQGYVALLGSDDQSWGWNLVDNQLLHNSKPISPYPHINNPPKYQMGERIRMIVDCEQHSMYFEKGSEFLGIAFSRLPPLKLFPAMCAVYGNTEVSMVYIGPPLLG
What is the function of this protein?
Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which may regulate restriction and/or maturation of synapses.
What are the official names of this protein?
F-box/SPRY domain-containing protein 1, F-box synaptic protein 1.
What is the protein family that this protein belongs to?
Belongs to the FBXO45/Fsn family.
What are the subcellular locations of this protein?
Synapse.
Protein: MRAZ_OCEIH
Sequence: MFMGEFLHSIDTKGRIIVPSKFRDNLGSSFVVTRGLDKCLFAYPMDEWKILEEKLKQLPLTKKDARAFTRFFFSGAIECEVDKQGRINIPANLRNYAGLEKDCNVIGVSNRVEFWANDAWEDYVTESEDSFAEIAENLMDFDI
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PYRH_PROM0
Sequence: MAYKRVLLKLSGEALMGEKPYGIDPAIVQSIAEDVSKVVENNVQLAIVVGGGNIFRGLKGSADGMDRATADYVGMLATVMNAISLQDGLERVGVATRVQTAIEMQEIAEPYIRRRAMRHLEKGRVVVFGGGCGNPFFTTDTTAALRAAEINAEVVMKATKVDGVYNCDPNKFKDAKKYSSLSYQQVLSDEIAVMDSTAIALCKDNNIPIMVFDIFKKGNISKAVDGDPIGSLIS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEC2_CAEEL
Sequence: MKNTHVDLICVFLSIFIGIGEAVDVYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHHAKLHNDDEVLHVEQLKGYTRTKRGYRPLEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASGDGGEDDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGPGAHAGTLKKFELMLHGTREAPYNLIEPIVGQTNKKLDTVQKAHKRSH
What is the function of this protein?
Serine endoprotease which cleaves preproteins at paired basic amino acids (PubMed:12657671, PubMed:15180830, PubMed:16945111, PubMed:23665919, PubMed:24671950).  Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides (PubMed:12657671, PubMed:16945111).  Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit (PubMed:23658528).  Regulates sensitivity to mechanosensory stimuli (PubMed:11717360).  By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions (PubMed:12657671).  Probably by processing flp neuropeptides, regulates the turning step of male mating behavior (PubMed:17611271).  Cleaves pro-insulin-like proteins ins-3, ins-4 and ins-6 into their mature active forms (PubMed:23665919, PubMed:24671950).  Together with convertase kpc-1, cleaves pro-insulin-like protein ins-18 (PubMed:24671950).  By controlling ins-4 and ins-6 processing and thus the activation of the daf-2/InsR pathway, negatively modulates synapse development and synaptic transmission at neuromuscular junctions (PubMed:23665919).  Similarly, by controlling ins-4 and ins-6 processing, negatively regulates dauer formation under optimal environmental conditions (PubMed:24671950).  Under adverse environmental conditions, may promote dauer formation by processing ins-18, a daf-2/InsR antagonist (PubMed:24671950).  May cleave dense-core vesicle membrane protein ida-1 (PubMed:15180830).  Involved in egg-laying, fat storage and locomotion (PubMed:11813735, PubMed:11717360, PubMed:17564681).
What are the official names of this protein?
Neuroendocrine convertase 2, NEC 2, Egg-laying defective protein 3, Kex2-like prohormone convertase 2, CELPC2, Prohormone convertase 2, PC2, Proprotein convertase 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family. Furin subfamily.
What are the subcellular locations of this protein?
Cell projection, axon. Cytoplasmic vesicle, secretory vesicle lumen. Secreted.
Protein: AGLUS_ARCFU
Sequence: MMLEGEFHTHMLPEFMIERRQDRCIRCRVCERQCGFNVHWYDEEMDMMREDEMKCVGCQRCAVMCPTNALVVKPHPGNYKPNANWTRERLQDLKKQAETGGVLLTGSGNDKPYRIYWDHIVLNASQVTNPSIDPLREPMELRTFLGRKQDRLEFKYSEDFEDIEITTELYPNVQIETPIVFSAMSYGAISYQAFKSLAMAASEFGTLFNTGEGGLPKELRKYGKNAIVQCASGRFGVDPEYLNVAAVVEIKIGQGAKPGIGGHLPGEKVTLPISVTRMIPEGTDALSPAPQHDIYSIEDLSMLIYALKEATNYEKPVSVKIAAVHNVAAIASGMVRAGADIIAIDGLRGGTGAAPKMIRDNVGIPVELALAAVDQRLRDEGIRNKASILVAGGFRCSADVVKAIALGADAVYIGTPALVAMGCTLCQKCHTGICNWGICTQDPYLAKRLNPEITAKRLVNLLRAWSHEIKEMLGGMGINAIESLRGNREQLRGVGLEDWELEVLGIKGAGE
What are the official names of this protein?
Archaeal glutamate synthase [NADPH], Archaeal NADPH-GOGAT.
What is the protein family that this protein belongs to?
Belongs to the glutamate synthase family.
Protein: DNAA_GLOVI
Sequence: METLWDGILSHLKGRLSRPTFETWIKPATAQQFEQDCLIIRTPNPFARSWLQQHYAGAIAQAGEQVIGRPIQVDFIVSEQSEEALKPVIEREPAPAAPPANVASLNSKYTFSRFVVGANNRMAHVAALAVAEMPGCNYNPLFLCGGVGLGKTHLMQAIGHYRLDIDTRTKIAYVSTERFANELIEAIRRDAMQTFREHYRRVDLLMIDDIQFIEGKEYTQEEFFHTFNALYESGKQIVIASDRPPQLIPRLQERLSSRFSMGLITDIQQPDIETRMAILQKKAEYENMFVPQDVIHHIASAYTTNIRELEGALIRAVAYVSISGLPMTVETISPILSPPRTRGEITDEAILELVCDELKVSAEDMRSDSRRRDISQARQLCMYLLRKYTDLSLPKIGQALGGKDHTTVLYAIDKIEQSKIRDPEVQRLLQRLGNRLEADARH
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUCM_SHIF8
Sequence: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_ENT38
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGGHLTHGSPVNFSGKLYNIIPYGIDESGKIDYEDMAKQAETHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAHGGNEELYKKLNSAVFPSAQGGPLMHVIAAKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEAVIERIKGKVLDICARFPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_ACTSZ
Sequence: MQLVFIRHGLSEWNALNLFTGWRDVNLSEKGVEEAKEAGRKLKAAGFEFDIAFTSVLTRAIKTCNLVLEESDQLWVPQIKTWRLNERHYGGLQGLNKAEAAAEHGDEQVRIWRRSYDVLPPVLDPKDPNSAHNDRRYAHLPADVVPDCENLKVTLDRVLPFWEDQIAPAIKAGKRVLVAAHGNSLRALAKHIEGISDEDIMGLEIPTGQPLVYELDDNLKVLSKRYL
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: THIM_BIFA0
Sequence: MTTASTTPNSDTSNLHEVAPDDPIRERIRQAAQNVREQTPLAQSFTNFVTINLVANAQLAAGGTAAMSFLPNDVTSLASSCGATYINVGTLLPFYRDALQEISEHLSRHGCKWVLDPVAAGVGVARTEILKGFKDYPPTVIRANASEALVLHDMWQLGDAAGTDEHNGPAGVEAADSVDAAITAATDLAAYLALHSPTHTGAVAVSGEVDLVTDGRLVYRLPGGSAMMTKITGAGCSLGGVTATYLAVADALVASLAASMLYNVSSGAAERASHGPGSFQTAFLDALWNVTPEEIASAPLYLA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: AIM23_CANDC
Sequence: MSLRIILKRDFSQCIRVFESGIKSSTTTTSNRFQAQYGNKNNDNTKRNTNNGNRFHNKYNNESRRSYPKTKYQQQYQQRKQPYIIDPRKIKFNNGTESARNAIEEIINRIYKLQKNYQIQLITNSGLKNYHLSEILQNLDLSINGLQLIDKSTSTTTTTTTTTTNNGGNELPLIKIITVREMINQYSTYLNNLKQLELIKLGSLKTLKTLDIKLKLEQKKSTTKEILIKWSINNNDFKLQKTNEIKKLIGNGNGGKNFLINMVYNKRNINKSIDTIYKYQCKGDEIEEKNLIEIELQRRQLLINNLQSLLTELNCKWIIEGDINTKMTFNVTPSISQSTTTTTTQEQEQEDYNDIEEKKLNRTERKKRKSQQQQQQQQQQQSKTNTTKKDEDEEDLDALYSFKIED
What are the official names of this protein?
Altered inheritance of mitochondria protein 23, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM23 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RRP3_CRYNJ
Sequence: MPSPSPEASSSMSQPGPPSRSPSPASSNPDAPEASHNKTFADLGISPELCRACASMGFKKPSDIQAEAIPHALEGKDIIGLAQTGSGKTAAFSLPILQTLWENPQPFFALVLAPTRELAYQISQQVTSLGSGIGVRTAVLVGGMDMMSQSIALSKRPHIIVATPGRLMDHLENTKGFSLKSLKYLVMDEADRLLDLDFGPIIDKILKVIPKERNTYLFSATMTTKVAKLQRASLNKPVRVEVSSKYSTVSTLLQHYLLLPLKNKDAYLLYLANELSSSSMMIFTRTVADSQRLSIILRRLGFPAIPLHGQMTQSLRLASLNKFKSGGRSILVATDVASRGLDIPLVDLVINYDMPTNSKDYVHRVGRTARAGRSGKSITLVTQYDVEILQRIESHIGKKMTSFDVDKEAVALLTDTVAKANREAALEMRESGTGGGGGKRGRDKGKRKTFGDGDDRDRDDDVVEAGVPRKKNKFTPGGKKKARK
What is the function of this protein?
ATP-dependent rRNA helicase required for pre-ribosomal RNA processing.  Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent rRNA helicase RRP3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURG1_BACCR
Sequence: MRVLVSGGGTGGHIYPALALIREIKKLNPEARFLYIGTENGLESTIVPKAGIPFQSIVISGFKRKISLDNVKTVMRFLKGVQDSKRYIRRFNPDIVIGTGGYVCGPVVYAAAKLGIPTIVHEQNSVPGVTNKFLSRYVDKVAVCFEAAIEHFPESKVVMTGNPRASEVMEQNGMKGKRSVGLSLPKKSVLIFGGSRGARPINDAFVEAIEQFGNKSYEILYVTGEVHYDKVMEAVKQKGNPSNVIIKPFIHNMPEVLTGVDLVVSRAGATTLAELTALGKPSVLIPSPYVTNNHQEKNARSVVDKGAAKMLLEKDLTAETLIRDIDEILLDTQTLQNMKLAAKQLGIPDAANKLYEVMNKLVKK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 1, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.