Protein: CM3A_CORMM
Sequence: MKHLASSENMPTPAQDRAPSPSAMQQEIVDMCAQVLGRPITRMRTSKSFVALGGDSLLAIKLMAHCREAGYTISIAKILQTASIEELSRSAECQLISSSGEGPVPDPNRPGEPIATSLSLLNNELVLDQVRNITAEPLEDIQDIFPCSRTQEVFLISQHANPEMYQCVVVAEIKCMKPGLSLNDDRLQNAWICVAQRHPALRTVFIESIQRPGHFDQVIMKHEAVPLECQLSSAQCEESAEGMFSRRVSISKEKGTTGRATILRRSENSAVFRLEVSHALMDGQSFGIIFHDFAQAYLQNELPSPTAFSYDSFVAYQEEIDRESVRAYWSSHLAGAQPTRFPTNGNRKLEDLKTLRFRIELDAAALQKVCLEYDATSANLCQVAWAVVLGSYTGSKDVCFSYVNSGRHAPLSSIENAVGAFVDVMVCRMKLPETAKISQMLSKAKQDVIQGLSHPGSLLFEEKKHGHGVSDLRGNTIITFQMGVRDEESAGSDLQIVMLDEITASDYDISLNIQPCHGGLDIRLDYWLSRIDQEIIESVAESFQTALACMCSDDIPLRDVNVVCTQEIEQLRRRNSYTATEIGSLLHDKVDEQARLCPDALAVQGWDGELTYRALNEEASKLASYLQHLGAQQDILICTCFEKSKWAAISQLAVLKSGAAVVPLGTNQPMKRLEMMITNTGADIVLTTSNFASRFVTLFKHVVVIDGASMAKLPLAATVSCSATPDSLAYVIFTSGSTGVPKGVMLTHDSVSTSLRHSVERLNPGPDTRMLQFSAYTFDAAIYEFFFTWHIGACVCIVSEHDRINRLEPAMGELNVNWALLTPTMAEMISPGQVPSLKHLMLIGEAIKPGVLHRWIDHVELWNGYGPSECSIISSCKLLTRECNTTNIGFPITGAFWVVDATNPDRLAPTGAIGELLIQGSHLARGYLNDEQKTSQAFVPPPAWVSKYAFSGSTRYYRTGDLVQRNKDGSITFVGRRDTQVKLRGQRVEFEDIEQHLKDHDAVVEAAIVLAADGPCQGQLVAVVALEAFISQEMHPKTLSPVDQQQIARAKLQTAILGDWLSDRVPEYMVPTMWIPVTSRLLQTDSGKLDRVRLGRCVDSVDVSWVEAFASAGEELTQEREATTLQLQIRDIWAEILLLSIPQVPINRRSFLSLGGDSILAMKAVSRARTQGITLTVPDILQSKSIAKLTEKLGVPEENFLSYTSASKPFPLSPTQKWYFDRVHPLGSGIRHGYCRSVCLQANQKLAEKHVSTSFSTLVSMHPMLRARFLADAANGWQQQVVGHSDDAYGFAVSHLNGFEEIHDIAESTEQGLNIENGPVFSVQFMHLHAGKEEGKQLLFITGHHLVMDEISLCIIIEDLERLLYQDSTVALVVERPSFQAWVEGIAKTTKEEGPEPTSASLTPGLKPLMSKLDLEFGSLTSNEPVYDETNTKVLQFDEFDTMVLLGNANQALRTEPVELILAALVMSFTTTFPSQCIPVLLEGSRGRSLNHGSIDNSKTVGCFTTTMPLRFPVANMDDAVKSTKQIKNARRNTKFRRLHDSQNRNARNYETISSLNRETMEIFFNFDDSSQQIQEQSTLFKQQLLPRRQKLSTGVQKTRHSEIDVDATILQSRLHVAFHFNHRMNHGSDVERWSCEFPKTLRALVATLLKTPSMLTLSDFPLVELTDQKLKILEGQTLPRVGVQPENVEDMYPCTPMQNGILMSQARSPGMYQTQVVWQLQSPDSRINLDVERIMHAYQTLTDRHPMLRTIFVPRTSNAGDGAFDQIVIRRYRINVVHQVCEQDSVEALLATMTNPSAVDYGDGPNHKFMVYSTPSNLTYGHLVINHALSDGFSLSLLEKELTEAYEGTLTPDSKAPPYSAYLSFLKQRSTKEALQYWINNLESAEACFLPAMVERKIQNESETDIVSLPAPSRRQSTTASLEGVESLRKFSEKHSVTMANVFQLAWALVLSKFVRSDDVLFGYVSSGRDVPVHEAHQIFGPFVNILVSRIKLDWDSSIAESLQSVQKRFFENLGQQRTPLVDIWHALKTGGRGLFNTYLSYRQLSSADGQRSGLFQHTIAILGDSEYDAGVDIVASSNKVSVTLDYLPSFMGHDAATRIVDCLLQTVQSLTQSEAFLLRNVTTTTGQDIRQICQWNSEVPLVTVQHCVHDTVYSKCCLDPSAKAICAWDGDLTYFELDQLGEQLAFYLTSNLSVTPETMIGVCFDKSRWAIVAQLAILKSGGAIVPINPMEPMQRLETILRESGICTLLTTSCYGDRFLEIIPNVVAVDSNSPFFHGAMPTERVHSTANPDNAAVVIHTSGSTGNPKGVVLTHRSIASSLEAQGKIFGLSSRTRTLQFVSYTFDLSIGDIWGTLSHGGCVCVMSEDDRMNNIQGAIQIYGATLVIMTPTVATLLDVSKLPSLETLVLGGEALKPAFVEKHLEARQIKIFNGYGPSECSMITTCNGPIQHKNEAPKIGRPLLGSVWLVDDTDKICPIGAVGEIWVEGPLVARGYLNKKDLTDKGFPVDPPWAASAGLQGKRFYRTGDMARQNAKGDLFYVDRKDWQIKIRGNRVELSEIEHAIKEILSGLQNVAACLVSSNQRGPLIAAVLEQNCDTLGLQADVAGFHFERLSPGFQKELVLLKKALAGVLPSHMIPNLYVPTTRLPLTASGKVNRQALRQSLESFSEQEALHYTLADAAKTLPSSETEKTVRALWAAVLQHELDQVGVEDNFFHLGGDSYLAMRLVASSQADDSRVHFTVSDVLQHPTIRELAHAIDQRSTHSRASDRETARFSLWKEYQELNKSQESGHAKALLDQIAAQCDVPIDDVEDIYPCTPLQEGLMVVTAQQPRAYIARWAFQMPDNINLERFQGAWQTLSRAVPILRTRIVPGRLSGALQVVVRGDCKWHTSHDLDQYLSDDVAQSMAYGTSLIRLAYINHSNGCRDFVWTAHHSIYDGWSLPMLLEALSRIYLFNEVPESFPPYSNFIQYIQAQDLAEATAFWRSELQGNLGEPFPALPKPSYQPEPARIIRCTINVESVNRLVTLASLLRAAWAATVSSHTGGTALFAMPLSGRNAPVKGILDMMAPTVTTVPVRIQVDEKQAVHDYLAAVQQQASNMVPFEHSGLHHVRSMVGRDINPQHLFAIQSAPPGKATFEELLGMKELTLPMDGFDNYALIVECFINSREGASIEILARFDDNVLSHTQVQHLLSRFKHIFGQLSQVSAGNNDNTSSMLMGGLEYISPEEVAQLAILNREVAADAPCLVHDLVLRYSATTPDRPAVCAWDGEMSFQQLDQLSEALANRLVELGVTIESPVMICCDKSKWAVVGILAILRAGGTVVPVRAAPVARLQAIMEATGSRVVVTMSEFISQLQGIADHVVSMDSVPVTKPEIPQGPVKQHPSTKSVSFIMFTSGSTGSPKGIVLEHGSMSIAIQSHVKRFGVNRHTRGFQFASFTFDMSLHDILTPLAGGGCVCLPSEVERVNNLAHAMRRFRVNYSMLTPRVLHTIKPSECPEIRTLLVGGERCDTEQLKLWLPQAKVWHVYGPVECSIISTAAEFTGSDTLSLGLALVGAVWVTNKDNCNQLCPIGAVGELLVEGPLVARGYLRDEAKTSAVFIDYPPWRKQHGLAPNSQSQRMYRTGDLVVQHEDGSLIFVGRADQQLKIRGQRVEVGDIEHHIGLQPEVEDGVVLYPQNGPCRSQLIGLVTLHEHMSATDLSEVQPSSADDLAKAITQTEIIRSRLSDVLPDYMVPNVWISMACLPQSAHHKVDRRKLMDWVQSLDAEYFRRITGAKQEAPEKPTTRTEELMQSVLADVLGLSPEDVSMGRSFLSMGGDSITSMQVVSQCRSRYGLSLHVRDILQSKSITQLAQRATTDAAIAPLLPASDGEFRLSPIQRLFFRSFAARGLQSEDEFRFNQSVCLTVNKHIDTEQIKHAARGVVSAHPMLRARFTVSGKRWRQRIEDDVDASCHVVFHQVENQAELEDVIWAGQRSLSVEQGRVFSVHCIETTTTGSQLLFLVAHHLVVDIVSWQIILRDLDNLIQHPKLTAPVESTTFQHWLQLQASRAQNVGSPHQLVHAQMPIADWSYWGVTPENNTYGHRINEQFILEDCASVLFGDKQPLRSEPVEVLLAALFHSFHQIFPDRAVPTVFNEGHGREPWSDAIDLSNTVGWFTTMTPIHVPVGTSDVVDVLKRTKDLRRSIPERGFAYFTSRFLTRDGQHAFASHDQPEVMFNFGGRYRDDKHSRSLFRMSNEFNSSHISGIGNNVKRIAVFEVEASIQQENLAVTLGFSKNMQNPERITRWIQAYQDSLKTLLCQLSTLPTFLSLADVPLLNITYDDLDRLQSERLPLVGINDIDCIEDIYPCSPAQESILRSQARDSSTFHVRSACEFRAREAVVNPEALIRAWQTVVARHAILRTVCVPPTCDGESFYQAVLKQYEPQVSTVRCETAEDVDEAFKDEGGLRYPKWKPEHQLTLCLTSTGQVFFRLLINHTLVDVSSLQLIMNEVTLAYEDGILDTAAPSFSKYIAFLQESSVSESMKYWTSRLAGAQPHCLPVSATVGDGQSRDNAHLEMSNLEPLWRFRDRYGITIANILQLAWAFVLAKHSGSRDVVFGYVANGRDAPVDGVSHMAGPLINVMVSRIWLGDKQRSVAKTAEQVQNDFMEAFRYQRVSLADIEQVTGLSERQMLHTVVSIVRDPGSRRSSDAGVSVHGQSATSLAEYDVSLNAACGEDAIKLSLEYSSRYPGSVSAKGLLDNLQKAVLDLAENGEASIEEMGLRC
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of beauveriolides I and III, cyclodepsipeptides acting as inhibitors of the acyl-CoA:cholesterol acyltransferase (PubMed:31926180).  The HR-PKS cm3B initiates the biosynthesis of beauveriolides by iteratively catalyzing the formation of the linear polyketide chain (Probable).  The ATP-dependent acetyl-CoA ligase cm3D converts the polyketide carboxylic acid to a CoA thioester which id shuttled to the first T domain in the NRPS cm3A by the acetyltransferase cm3C (Probable).  Cm3A contains 13 domains and assembles the polyketide chain, L-phenylalanine, L-alanine, and D-leucine (or D-allo-isoleucine) to form beauveriolide I (or beauveriolide III).  The production of both beauveriolides I and III suggests the substrate adaptability of cm3B, using different amino acids as substrates (Probable).
What are the official names of this protein?
Nonribosomal peptide synthetase cm3A, Beauveriolides biosynthesis cluster protein A, Cyclodepsipeptides cm3 biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the nrps family.