PharMolix/UniProtQA huggingface dataset:
Protein: RIMP_MYCA9
Sequence: MPDPLDPSDSSTGLPSDDQVLELLAPEFSRSGVEIESVVVSDGGVAGRPSRIAVVVDSDTPVDLDAVAGLSRTASALLDEADTGWQAYELEITTPGVDRPLTTVAHFRRAHLRLAQIRLTNGEDLLGRIGITHDDGVQVVLRKPIKGTGWTVRDLAFSDIESAVVQVEFNTPNPQELNLAGAAETGGGA
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFGH1_ECOUT
Sequence: MELIEKHASFGGWQNVYRHYSQSLKCEMNVGVYLPPKAENEKLPVLYWLSGLTCNEQNFITKSGMQRYAAEHNIIVVAPDTSPRGSHVADADRYDLGQGAGFYLNATQAPWNEHYKMYDYIRNELPNLVMHHFPATARKSISGHSMGGLGALVLALRNPDEYVSVSAFSPIVSPSQVPWGQQAFAAYLGENKDAWLDYDPVSLISQGQRVAEIMVDQGLSDDFYAEQLRTPNLEKICQEMNIKTLIRYHEGYDHSYYFVSSFIGEHIAYHANKLNMR
What is the function of this protein?
Serine hydrolase involved in the detoxification of formaldehyde.  Hydrolyzes S-formylglutathione to glutathione and formate (By similarity).
What are the official names of this protein?
S-formylglutathione hydrolase FrmB, FGH.
What is the protein family that this protein belongs to?
Belongs to the esterase D family.
Protein: TOLB_RICPU
Sequence: MRNIIYFILSLLFSVTSYALETINIEHGRADPTPIAVNKFDADNSAADVLGHDMVKVISNDLKLSGLFRPISAASFIEEKTGIEYKPLFAAWRQINASLLVNGEVTKLESGKFQISFILWDTLLEKQLVGEILEVPKNLWRRAAHKIADKIYEKITGDAGYFDTKIVYVSESSSLPKIKRIALMDYDGANNKYLTNGKSLVLTPRFARSADKIFYVSYATKRRVLVYEKDLKTGKESVVGDFPGISFAPRFSPDGRKAVMSIAKNGSTHIYEIDLATKRLHKLTDGFGINTSPSYSPDGKKIVYNSDRNGVPQLYIMNSDGSDVQRISFGGGSYAAPSWSPRGDYIAFTKITKGDGGKTFNIGIMKACPQDDKNSERIITSGYLVESPCWSPNGRVIMFAKGWPSSAKAPGKNKIFAIDLTGHNEREIMTPADASDPEWSGVLN
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ATPI_DRANE
Sequence: MTVLSCSINTLIKEGLYEISGVEVGQHFYWQIGGFQVHAQVLITSWVVIAILLGSAVLAVRNPQTIPTDGQNFFEFVLEFIRDVSQTQIGEEYGPWVPFIGTLFLFIFVSNWSGALLPWKIIQLPQGELAAPTNDINTTVALALLTSVAYFYAGLSKKGLGYFSKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: OR49B_DROME
Sequence: MFEDIQLIYMNIKILRFWALLYDKNLRRYVCIGLASFHIFTQIVYMMSTNEGLTGIIRNSYMLVLWINTVLRAYLLLADHDRYLALIQKLTEAYYDLLNLNDSYISEILDQVNKVGKLMARGNLFFGMLTSMGFGLYPLSSSERVLPFGSKIPGLNEYESPYYEMWYIFQMLITPMGCCMYIPYTSLIVGLIMFGIVRCKALQHRLRQVALKHPYGDRDPRELREEIIACIRYQQSIIEYMDHINELTTMMFLFELMAFSALLCALLFMLIIVSGTSQLIIVCMYINMILAQILALYWYANELREQNLAVATAAYETEWFTFDVPLRKNILFMMMRAQRPAAILLGNIRPITLELFQNLLNTTYTFFTVLKRVYG
What is the function of this protein?
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates.  The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration.  May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
What are the official names of this protein?
Odorant receptor 49b.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or30a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y420_TREPA
Sequence: MRRRIYEERGAVRQAGLAHVFEYQGGAAHTGAVQDSDWAVVMRGDIAITLVYAQPVSMPPVLPLPDFAFQACCSY
What are the official names of this protein?
Uncharacterized protein TP_0420.
Protein: SCX9_CENNO
Sequence: KKDGYPIQENGCKY
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Beta-toxin Cn9, Toxin-9, Toxin II-14.4.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FMT_MYCSK
Sequence: MRLVFAGTPEPALPSLQRLIASPRHEVVAVLTRPDAAAGRRGRPTPSPVARLALDHDIPVLRPPKPNSEEFVAELRELAPDCCAVVAYGALLSERLLAVPPHGWINLHFSLLPAWRGAAPVQAAIAAGDAVTGATTFLIEPALDSGPVYGVVTETIRANDTAGELLTRLAESGAHLLESTLDGIADGRLQAVPQPADGVTVAPKITVDEARVRWDLPAHVVDRRIRAVTPNPGAWTVIGDARVKLGPVAPESAEPLAPGAIRVLKNAVHVGTATEPVRLGTVQPPGKKPMNAADWARGARLDASVSAQ
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: OTC_RUEST
Sequence: MNHFLDIHKTAPEDLRQIIDQAGQMKTARLGRPKGTPDDEQPLAGHMVALIFEKPSTRTRVSFDVGVRQMGGETMVLSGKDMQLGHGETIADTARVLSRYVDMIMIRTFDETVLTEMAEYADVPVINGLTDRTHPCQIMADILTYEEHRGPIKGKKVVWTGDGNNVCASFLHAAGQFGFDLTFTGPAQLDPEDEFIGFARNAGSKITIERDAAKAVEGADLVVADTWVSMHDSQSSKERRHNMLRPYQVNDALMAHAKPDALFMHCLPAHREEEVTSAVMDGPQSVIFDEAENRLHAQKAVMRWCLGV
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_SHEDO
Sequence: MQQLTEIVAQALAEVANASDLKALDDIRVDYLGKKGKITDMMKMMGSLSAEEKPAFGQAVNQAKQAVQQTLSERIDGLKASELEAKLIAEKIDVTLPGRTLELGGLHPVTRTIERIETFFGELGFVVKQGPEIEDDFHNFDALNISEHHPARADHDTFYFNPKVMLRTQTSGVQIRTMEHEKPPLRIISPGRVYRNDYDQTHTPMFHQVEGLMVAENVNFAELKGILHDFLRNFFEEDLQVRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRSVGIDPEKYSGFAFGMGVERLTMLRYGVNDLRAFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y665_METJA
Sequence: MINLDVWIDLTNAPHVHYFCQLIKKFEKEGIEYLLTFRDSGNLAKLVEIYNFVGKCIGKHGNTLKDKLIFYAERVIGLTELISNVKPKVAIAKHSVELPRVAFGLNIPVIFVVDNEHAEAQNKLTLPLADEIIKPIATDENKLKEFGGRNFISFEGTCEVANVNSRLKGYYPIDNEILKKLGICDDNPTIVMRPCPNSSYCNGHKDILPKIIEKLQKRIDCNIVVFPRDEHQKEIYREVNAIVPKETIDALSLLYNSDFMIGAGGTMNRESAILGIPTVSCYPQELLGVDKYLIEKDRMIHTNDIKEIINYVEDNLGKRMGVIELEDPTDLMFERVCNYLK
What are the official names of this protein?
Uncharacterized protein MJ0665.
Protein: COAD_MYCMS
Sequence: MKTAIYPGSFNPFHNGHLNILKKAILLFDKVYVVVSKNINKSLDPDLQSRVKNIKNLIRDFNNVEIIINENKLTTTIAKELNASFIIRGLRSQTDFEYEIKYYDGFKSLYPNIEVIYFISDYDKRSLSSTILREIEFYKK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1M_HUMAN
Sequence: MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:1959619).  Essential for the catalytic activity and assembly of complex I (PubMed:26929434, PubMed:1959619).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL7_FINM2
Sequence: MSIDEILEAVEGLTVLELNELVEKAEEKFGVSAAAPVAVAGGAPAAGGAAAEEKSEFDVILASAGEAKMKVIKAVKDLTGLGLKDAKALVDEAPKAIKEGASKEEAEELKAKLEEVGATIELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: YSIG_LACLA
Sequence: MNQYFTYILQCSDKTLYCGYTTDLEKRLATHNSGKGAKYTKTRLPVKLLASVDFDNKNDAMSCEWWFKHKLVRKQKLSLIKNDLIKEKFIEYLELKQKKNIHLK
What are the official names of this protein?
UPF0213 protein YsiG.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: RL4_BURL3
Sequence: MELKLLNENGQEGAVVNASDVVFGRDYNEALIHQVVVAYQANARQGNRAQKDREQVKHTTKKPWRQKGTGRARAGMSSSPLWRGGGRIFPNSPEENFSHKVNKKMHRAGLCSIFSQLAREGRLSVVEDIILEAPKTKLLAEKFKTMGLDSVLIITDTVDENLYLASRNLPHVAIVEPRYADPLSLIYFKKVLVTKAAVAQIEELLS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TILS_BORGP
Sequence: MHFLDDNIQIKIDKFYKKNSLNKNRVIVAFSGGADSTTLLLNLKYYLSNNIVAFYFAHFIRTDNEQNKEIEHVKGFCDLYNIALQVKKCDIDIKSESVRLGVSIEELARKCRYNALENALKENDANYIALAHNENDQIETIIMRFFQGSFLDGLSGIPGVNKNIIRPLLEVSRLEIENFLSLNNISFFVDSTNAQDLYLRNRVRNNLLPSIEKIFKGYQKCLKRISEFSKEFVDYFEKDEFFPVEKGKYYYSFDLKTFLNFPKYLVFRLIFKILNSEGIVAKVSYKALNEAFKVEINRKKNNVLLKTNDFFLEKRHNKINLIFKRDEKFYKPFDFILEVGKWHSLSLGKILLKCLECNTSSVSRLKCCSYEFRYKFFKDRFKAKKFFSKFIRCNPIYLMLLALDNRLIGIIDLNTLNLVWSEKSILKKISISLIGGLLKE
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAD4_SCHPO
Sequence: MGSSKPLKGFVICCTSIDLKQRTEISTKATKLGAAYRSDFTKDVTHLIAGDFDTPKYKFAAKSRPDIKIMSSEWIPVLYESWVQGEDLDDGLLVDKHFLPTLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQSIQRNAVLEPQYFQLDMPAEKIGLGAYVRLDPNTTEAKSYSENQKISKNKEKSGQSLAALAEEADLEPVIMKRGKKRDRSILWEELNNGKFEFSSRSEENSVLLDDFTPETVQPLEENELDTELNIENEAKLFKNLTFYLYEFPNTKVSRLHKCLSDNGGQISEFLSSTIDFVVIPHYFPVDELPIFSFPTVNEWWIERCLYYKKIFGIDEHALAKPFFRPSLVPYFNGLSIHLTGFKGEELSHLKKALTILGAVVHEFLGVQRSILLVNTNEPFSMKTRFKIQHATEWNVRVVGVAWLWNIIQSGKFIDQVSPWAIDKKENQEIKKFTNQNNMVFPTSDRDTRLQNSLAQQPIGHSTPHNSPSLLSVKKRQNNHIRSNTLIQLNSNSKDSTIFPRRSVTVPGDKIDTVWKSSVTKPETPTSPQEHVSYIDPDAQREKHKLYAQLTSNVDAIPPANDLQNQENGLLLITESHRKLRRR
What is the function of this protein?
Essential component for DNA replication and also the checkpoint control system which couples S and M phases.  May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis (PubMed:8343962, PubMed:7957098).  Interacts simultaneously with both 'Thr-187' phosphorylation sites in a crb2 dimer for establishing the DNA checkpoint (PubMed:24074952).
What are the official names of this protein?
S-M checkpoint control protein rad4, P74, Protein cut5.
What are the subcellular locations of this protein?
Nucleus.
Protein: TBB_EIMTE
Sequence: MREIVHVQGGQCGNQIGAKFWEVISDEHGIAPTGTYKGDSDLQLERISVFYNEATGGRYVPRAVLMDLEPGTMDSVRSGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQVTHSLGGGTGSGMGTLLISKVREEYPDRIMETFSVFPSPKVSDTVVEPYNATLSVHQLVENADEVQVIDNEALYDICFRTLKLTTPTYGDLNHLVSAAMSGVTCSLRFPGQLNSDLRKLAVNLVPFPRLHFFLIGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMCASDPRHGRYLTACALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNMKSGVCDIPPKGLKMSVTFVGNSTAIQEMFKRVSDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEEEGVMDAEGAA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y949_AROAE
Sequence: MSAITSNLTHHFLIAMPNMADPNFVRSLTYIAEHNEQGALGIIVNRPIDMTLAALFERIDVPLEADGLAGQPVYFGGPVQTDRGFVLHRPAGEWHSTLVVNDEVGLTSSRDILQAVGSSGEPPEVLVTLGYAGWTAGQLEQEIADNSWLTVPADLAIVFGLPPEERLAAAMQMLGIDFANLSESAGHA
What are the official names of this protein?
UPF0301 protein AZOSEA09490.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: HYPC_SHIFL
Sequence: MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPDVGALLYGEEK
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Involved in the biosynthesis of the Fe(CN)(2)CO cofactor.  HypC delivers iron-bound CO(2) to HypD where reduction to CO probably occurs.  In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand.
What are the official names of this protein?
Hydrogenase maturation factor HypC.
What is the protein family that this protein belongs to?
Belongs to the HupF/HypC family.
Protein: TRPB_SHEON
Sequence: MSQLKLNPYFGEYGGMYVPQILVPALKQLESAFVEAQTDESFQAEFTDLLKNYAGRPTALTLTRNLSPNPMVKIYLKREDLLHGGAHKTNQVLGQALLAKRMGKKEIIAETGAGQHGVATALACALLGLKCKVYMGAKDVARQSPNVFRMRLMGAEVIPVTSGSATLKDACNEAMRDWSGSYEKAHYLLGTAAGPHPFPTIVREFQRIIGEETKKQILEREGRLPDAVIACVGGGSNAIGMFADFIDETNVELIGVEPAGKGIDTHMHGAPLKHGKTGIFFGMKAPLMQDSEGQIEESYSISAGLDFPSVGPQHAHLNAIGRARYESATDDEALEAFQLLARCEGIIPALESAHALAYALRLAKECTKETILVVNLSGRGDKDIFTVSDILNGKEE
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: TRPR_ECO5E
Sequence: MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAT_HV1EL
Sequence: MDPVDPNLEPWNHPGSQPRTPCNKCHCKKCCYHCPVCFLNKGLGISYGRKKRRQRRGPPQGGQAHQVPIPKQPSSQPRGDPTGPKEQKKKVESEAETDP
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: SELO_YERP3
Sequence: MEYAPEFDNSYARQLSGFYTRLQPTPLKGARLLYHSKPLAQELGLDAHWFTEPKTAVWAGEALLPGMEPLAQVYSGHQFGMWAGQLGDGRGILLGEQRLNDGRYMDWHLKGAGLTPYSRMGDGRAVLRSVIREFLASEALHHLGIPTSRALTIVTSDHPIYREQTERGAMLLRVAESHIRFGHFEHFYYRQQPKQVQQLADYVIARHWPQWVGHQECYRLWFTDVVERTARLMAHWQTVGFAHGVMNTDNMSILGITMDYGPFGFLDDYVPGYICNHSDHQGRYAYDNQPAVALWNLHRLGHALSGLMSADQLQLALEAYEPALMVAYGEQMRAKLGFLERDSQDNDLLTGLLSLMIKEGRDYTRTFRLLSEVEVHSAQSPLRDDFIDRAAFDDWYRRYRSRLQQESIDDDQRQQSMKAANPKYILRNYLAQQAITQAEKDDIQPLQRLHQALQQPFTDQPEFDDLAALPPDWGKHLEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: RS19_CLOBA
Sequence: MSRSTKKAPFVHEGLLKKIEEMNASGDKKVVKTWSRSSTIYPQMIGHTIAVHDGRKHVPVYLSEDMVGHKLGEFVLTRTYRGHVADKTSKRK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: IRF2_HUMAN
Sequence: MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVPSDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVPYNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC
What is the function of this protein?
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes.  Also acts as an activator for several genes including H4 and IL7.  Constitutively binds to the ISRE promoter to activate IL7.  Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth.  Antagonizes IRF1 transcriptional activation.
What are the official names of this protein?
Interferon regulatory factor 2, IRF-2.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TPL_NOSP7
Sequence: MTDAKQTSPRRRRSWAEPYKIKVVEPLKITTRAEREQAIAQAGYNTFLLRSEDVYIDLLTDSGTSAMSDYQWAGMMLGDEAYAGSKNFYNLEASIQKYYGYRHIVPTHQGRGAENILSQILIKPGDYIPGNMYFTTTRLHQELAGGTFVDVIIDEAHDAQSLHPFKGNVDLQKLTDLIERVGAERIPYISVAGTVNMAGGQPISMANLRAVHQLAQTYGIRIILDATRAVENAHFIQQREEDYSSQAIATILREFCSYTDGCTMSGKKDALVNIGGWLALNDYNLYEEARNLIVIYEGLHTYGGMAGRDMEAMARGIEESVQDDHIRARVGQVEYLGQKLLDWGIPIVVPIGGHAIYLDAKRFLPQIPQDQFPAQRLAAELYLEAGIRAMERGIVSAGRNKETGDNYYPELELVRLTIPRRVYTQAHMDLTAEAVEEVYHNRDRLRGLKMIYEPKYLRFFQARFELQ
What are the official names of this protein?
Tyrosine phenol-lyase, Beta-tyrosinase.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: NCAP_I35A3
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIGGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRVNGKWMRELILYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRKTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEFEDLTFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEREGYSLVGIDPFRLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTKVVPRGKLSTRGVQIASNENMEAMESSTLELRSKYWAIRTRSGGNTNQQRASAGQISIQPTFSVQRNLPFDRTTVMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKAASPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.