PharMolix/UniProtQA huggingface dataset:
Protein: SYH_GEOSW
Sequence: MAFQIPRGTQDILPGEVEKWQYVEKIARDICKRYNYHEIRTPIFEHTELFLRGVGDTTDIVQKEMYTFEDRAGRSMTLRPEGTAPVVRSFVENKMYGNPNQPIKLYYIGPMFRYERPQAGRFRQFVQFGVEAIGSNDPAIDAEVIAMAMELYRSLGLKKLRLVINSLGDVETRKAHRQALIDHFKSRIHELCEDCQVRLEKNPLRILDCKKDRDHELMATAPSILDYLNDESRHYFEKVKAYLTKLGIPFEVDPRLVRGLDYYHHTTFEIMSDAEGFGAITTLCGGGRYSGLVQEIGGPETPGIGFALSIERLLAALEAEGITLPISEGIDCYVVAVGEKAKDESILLVHKLRKAGIVADKDYQDRKIKAQLKSADRLNAKFVAILGDDELAKEVINIKEMSTGEQTEVPLHSVVDYLKERLS
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR8_NANDO
Sequence: MGRDTIADIITSIRNADMDKKGTVRIASTNITETIVKILLREGFIENVRKHRENDQFFLVSTLRHRRNRKGPYRTILKRISRPGLRIYSNYQRIPRILGGMGIVILSTSRGIMTDREARLEGIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: S31F3_HUMAN
Sequence: MLSPTFVLWDVGYPLYTYGSICIIALIIWQVKKSCQKLSLVPNRSCCRCHRRVQQKSGDRTSRARRTSQEEAEKLWKLLFLMKSQGWLPQEGSVRRILCADPCCQICNVMALEIKQLLAGENNQISLTSLGPSQGSSCLEALSTSSVSFKHSQDLGSPKSKELSLASVTPTLSQLMDQKSLTQSAARSAGADSVQDSWADHFQRGQRSQVPAVSQVMGSLSSNFEKPGIPLSQQERTKNNSKFVLENQEAPEVGLDNKMKLFLHWINPEMKDRRHEESILLSKAETVTQDRTKNIEKSPTVTKDHVWGATTQKTTEDPEAQPPSTEEEGLIFCDAPSA
What are the official names of this protein?
Protein SPATA31F3, Protein FAM205C.
What is the protein family that this protein belongs to?
Belongs to the SPATA31 family.
Protein: HFLD_SHESA
Sequence: MNEQLHNRTMAFAGILQAIAQVQHLARHGESDTDELAASLNTILVTDPESAADVYQDKAALHKGYQLVLNQLGDSSQKDVEITRYLVGILALERKLTRSNSGLAMLAERINQVNRQLHHFAITDEQVIANLASIYSDIISNLGPKIQISGNPLCLQRPLVQHKIRALLLAAMRSAVLWRQLGGKRRHLVFARKAIIDTAKKSLTL
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BAS1_YEAST
Sequence: MSNISTKDIRKSKPKRGSGFDLLEVTESLGYQTHRKNGRNSWSKDDDNMLRSLVNESAKELGYENGLEDVKTIQQSNHLSKCIAWDVLATRFKHTVRTSKDVRKRWTGSLDPNLKKGKWTQEEDEQLLKAYEEHGPHWLSISMDIPGRTEDQCAKRYIEVLGPGSKGRLREWTLEEDLNLISKVKAYGTKWRKISSEMEFRPSLTCRNRWRKIITMVVRGQASEVITKAIKENKNIDMTDGKLRQHPIADSDIRSDSTPNKEEQLQLSQQNNPSLIKQDILNVKENESSKLPRLKDNDGPILNDSKPQALPPLKEISAPPPIRMTQVGQTHTSGSIRSKVSLPIEGLSQMNKQSPGGISDSPQTSLPPAFNPASLDEHMMNSNSISDSPKHAYSTVKTREPNSSSTQWKFTLKDGQGLSISNGTIDSTKLVKELVDQAKKYSLKISIHQHIHNHYVTSTDHPVSSNTGLSNIGNINGNPLLMDSFPHMGRQLGNGLPGLNSNSDTFNPEYRTSLDNMDSDFLSRTPNYNAFSLEATSHNPADNANELGSQSNRETNSPSVFYPQANTLIPTNSTATNNEIIQGNVSANSMSPNFNGTNGKAPSSTASYTTSGSEMPPDVGPNRIAHFNYLPPTIRPHLGSSDATRGADLNKLLNPSPNSVRSNGSKTKKKEKRKSESSQHHSSSSVTTNKFNHIDQSEISRTTSRSDTPLRDEDGLDFWETLRSLATTNPNPPVEKSAENDGAKPQVVHQGIGSHTEDSSLGSHSGGYDFFNELLDKKADTLHNEAKKTSEHDMTSGGSTDNGSVLPLNPS
What is the function of this protein?
Activates HIS4 transcription only in combination with PHO2/BAS2.  BAS1 is also involved in the regulation of the purine biosynthesis pathway.
What are the official names of this protein?
Myb-like DNA-binding protein BAS1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLMH_YERPG
Sequence: MKLQLVAVGTKMPDWVQTGFIEYLRRFPKDMPFELAEIPAGKRGKNADIKRILEKEGELMLAAVGKNNRIVTLDIPGTPWETPQLAQQLERWKQDGRDVSLLIGGPEGLAPACKAAAEQSWSLSPLTLPHPLVRVLVAESLYRAWSITTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDCC_SHIF8
Sequence: MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEKDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSLGKLNTLSMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PURA_RHIL3
Sequence: MTNVVVVGSQWGDEGKGKIVDWLSERADIVVRYQGGHNAGHTLVIDGTSYKLSLLPSGVVRPGKMAVIGNGVVVDPHALIAEIGRLEAQGVTVTPDNLRIADNATLILSLHRELDAMREDAASNSGTKIGTTRRGIGPAYEDKVGRRAIRVMDLADLDSLSGKVDRILTHHNALRRGLGVAEVSHQAIMDELTSVADRVLPFRDTVWLFLDKERRKGSRILFEGAQGTLLDIDHGTYPFVTSSNTVAGQAAAGSGMGPGSLGYILGITKAYTTRVGEGPFPTELKDAIGEFLGEKGHEFGVVTGRKRRCGWFDAALVRQSIATNGITGIALTKLDVLDGLEELKICVGYMLDGEQIDHLPASQGAQARVEPIYITLEGWKESTVGARSWADLPAQAIKYVRQVEELIGAPVALLSTSPERDDTILVTDPFED
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EST5C_DROMI
Sequence: MLAARLIILLSFYWLSASAIDPADPLFVDLPHGKIRGRDNGFYYSYESLPYAEPPVGELRFEAPQPYKQQWTDTFDATQPPVTCMQWNQFIFGDNKLAGVEDCLTVSIYKPKNTSQSSFPVVAHMHGGAFMFGEARQNGHENMMREGKLILVKISYRLGPLGFASTGDAGLSGNFGLKDQRLALLWIKQNIASFGGEPENIIVVGHSAGGASVHLQMLREDFAQVAKAGISFGGNAMDPWVIHRSARGRTFELGRIVGCGQASDSMELKNCLKSKPAGEIVSAVHSFLVFAYVPFAPFGPVVESPDAPEAFISQHPVDIIKSGKFAQVPWAVTYNTEDGGYNAAVLLEKQASSGRELIFDLNDHWFDWAPYLLFYRDSMTTIKDMDDYSRKLRQEYLGDRRFSVESYWDLQRLFTDVLYKNATELALDLYRKHGKSPVYAFVYDNPANTGIGQFFAKRTDVHFGTVHGDEYFLIFENLARGPEMRSDEEIISRNFLNMINDFVLSGNGTMTFGNCVLQDNVGSNKLQLLSITKNGCENLQLESFP
What are the official names of this protein?
Esterase-5C, Est-5C, Carboxylic-ester hydrolase 5C, Carboxylesterase-5C.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: NIKR_HELHP
Sequence: MKSSIIRFSVSLPQNLLETLDERLTHKGYSSRSEIVRDMIREKLNEEIWSSGAENTQGVAVLTIIYDHHQRELNQRMIDIQHTSTHKGNVEILCNTHVHLDQHNCLETIILRGNGVHIEDLSIEIGGLKGVKFSKLTRASRFE
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: NRAM1_RAT
Sequence: MIRDKNPQRVNRPSYGSISSLPSPAPQPEPSRNTYLSEKIPIPSTEQLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEICHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAISFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGFLVTIMALTFGYEYVVARPSQGALLKGLFLPSCPGCGQPELLQAVGIVGAIIMPHNIYLHSALVKSREVDRTRRGDVREANMYFLTEATIALFVSFIINLFVMAVFGQAFYQQTNEEAFNICANSSLHNYAKIFPRDNNTVSVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPAVMQEFANGWLSKVITSCIMALVCAINLYFVISYLPSLPHPAYFGLVALLAIGYLGLTAYLAWTCCIAHGAKFLTHSSHQRFLYGLPIEEQEGREGSG
What is the function of this protein?
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens.  Macrophage-specific membrane transport function.  Controls natural resistance to infection with intracellular parasites.  Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity).
What are the official names of this protein?
Natural resistance-associated macrophage protein 1, NRAMP 1, Solute carrier family 11 member 1.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATPG_MYCPN
Sequence: MAFIQEIKRKMTTVQSTIKITNAMKMVSRAKFVRFKKQFKEVNYFFNEFYKAVGQVVLSLKKMPKPLENPKTLWVMMSSSLGLCGQHNTNMNKLLQTKFQPGDKIFFLGRKNQSFWNKGDTDNPTVGYVDIQDRDLSFDYCQQVSDQIMEQFDLHQLDRICIIYTQFKNPLIQHANSFQVFPFDVAMFKAFNPVKMEQKLDFEPDEETIIKLISPQFFDIALYGGLVETKLCESASRQNAMDAAAKNAKDLYEKYSIQFNKLRQNSITQEIIEIIGGIS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ARCA_CLOP1
Sequence: MRDDRALNVTSEIGRLKTVLLHRPGEEIENLTPDLLDRLLFDDIPYLKVAREEHDAFAQTLREAGVEVLYLEVLAAEAIETSDEVKQQFISEFIDEAGVESERLKEALIEYFNSFSDNKAMVDKMMAGVRKEELKDYHRESLYDQVNNVYPFVCDPMPNLYFTRDPFATIGHGITLNHMRTDTRNRETIFAKYIFRHHPRFEGKDIPFWFNRNDKTSLEGGDELILSKEILAVGISQRTDSASVEKLAKKLLYYPDTSFKTVLAFKIPVSRAFMHLDTVFTQVDYDKFTVHPGIVGPLEVYALTKDPENDGQLLVTEEVDTLENILKKYLDRDIKLIKCGGGDEIIAAREQWNDGSNTLAIAPGEVVVYSRNYVTNEILEKEGIKLHVIPSSELSRGRGGPRCMSMPLIREDL
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTRH_METM5
Sequence: MFRFDKEQMVIEFAGAKFGGQPGEYPTALSGTIFYARHKIVEDAKKGIFDKKAAEALINKQAEMQDITGNSAFVQVFGGTEEALVNYIDFVSEVWDGPMLLDSTSGKARMAAANRATEAGYAKQCVYNSINVAAEDEEIENLTNSDVEASIVLCFDPMDPSVGGKLNVLNDGGKTKDIGMLELAEKAGIKYPLIDVAVTPMGNGAGHAVRASFAVKAKLGLPVGSGIHNVPSAWDWLREFRKGLREEGKDQISKDVHHVCDIGANIVQTMASGDYVLYGPIDNAELAFPAVAMTDMIIAETAKEMGTATVAEHPLNKLI
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.  MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit H, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H.
What is the protein family that this protein belongs to?
Belongs to the MtrH family.
Protein: EFTS_RAT
Sequence: MSLLRSLRFFPVACTGRSARAVLLQPSQPWHTLHAGPSLSSSASSKELLMKLRRTTGYSFVNCKKALETCGGDLKQAEAWLHKQAQKEGWSKAAKLHGRKTKEGLIGLLQEENTAVLVEVNCETDFVSRNVKFQQLVQQVALGTMAHCQNLTDQLSTYSKGFLNSSELSELAAGPDGEGSLKDQLALAIGTLGENMSLKRAAWVKVPSGFYVGSYVHGEMQSPSLQNLVLGKYGALVICQTPEQITNLEEVGRRLGQHVVGMAPLSVGSLDDEPGGETETRMLPQPYLLDPSITLGQYVQPQGVTVVDFVRFECGEGEQVAEAE
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, mitochondrial, EF-Ts, EF-TsMt, 2A3-2.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CWC22_PONAB
Sequence: MKSGVAQIKPSSGHDRRENLNSYQRNSSPEDRYEEQERSPRDRDYFDYSRSDYEHSRRGHSYDSSMESRNRDREKRRERERDTDRKRSRKSPSPGRRNPETSVTQSSPAQDEPATKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFGRLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDTDSNTDQDAGSSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSRDSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRNKDSENFRRKDRSKSREMNRRHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).  Promotes exon-junction complex (EJC) assembly.  Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.  Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
What are the official names of this protein?
Pre-mRNA-splicing factor CWC22 homolog, Nucampholin homolog.
What is the protein family that this protein belongs to?
Belongs to the CWC22 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins.
Protein: CYB_PUSSI
Sequence: MTNIRKTHPLMKIINNSFIDLPAPSNISAWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLYMHVGRGLYYGSYTFTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTDLVQWIWGGFSVDKATLTRFFAFHFILPFVVLALAAVHLLFLHETGSNNPSGITSDSDKIPFHPYYTIKDILGALLLILVLTLLVLFSPDLLGDPDNYIPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAIVPLLHTSKQRGMMFRPISQCLFWLLVADLLTLTWIGGQPVEHPYITIGQLASILYFMILLVLMPIASIIENNILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MIAA_THENN
Sequence: MKMAIVGGPTAVGKTDLMVEVCEEINAEIVSMDSRQIYRYMDIGTAKPTPEQRKRVPHHMIDILDPDEYYNAFLYRKDSLKAVEDILKRGKIPVYVGGTGLYADALVRGIFEGVPADENIRKELRELERREPGILRKMLEEFDPEAATRIHPNDLKRTIRALEVYMKTGRRISELQKETKGDDRFFIIVLTRERYDLYDRINRRVDRMVEMGLVDEVKRLLSMGYSKDLNSMKTIGYKEVIEYLEGKYDFEKMVHLIKRNTRHFARRQIIWFKRYENAIWYNLTFVSKEELKKTLKELIVKNFSV
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: QUEA_METC4
Sequence: MRVDLFDFELPEAAIALRPASPRDASRLLVVRPGDPLADRGVRDLPALLSPGDALVFNDTRVIPARLSGIRHRAGGSGQRCEAMLHLREAPDRWRAFARPAKRLAPGDRIRFGSEGASEVCALSGLDATVEERGEGGEILLRFDLSGPALDEAIAGLGALPLPPYIAGKRPTDAQDTTDYQTVYAREPGAVAAPTAGLHFSDALLAGIDAAGIERVHVTLHVGAGTFLPVKADDTDAHRMHAEIGILDAATAARLNAVRARGNRVVAVGTTALRLLESAADPDGTIRPFSGATDIFITPGYRFRAVDALVTNFHLPRSTLFMLVSAFAGLDTMRAAYAHAIQSGYRFYSYGDASLLFPEGAPVSESIT
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSGA_ECO55
Sequence: MSKNKLSKGQQRRVNANHQRRLKTSKEKPDYDDNLFGEPDEGIVISRFGMHADVESADGDVHRCNIRRTIRSLVTGDRVVWRPGKPAAEGVNVKGIVEAVHERTSVLTRPDFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIVLNKIDLLDDEGMAFVNEQMDIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGLQKEILTNDVSDNSGLGQHTTTAARLYHFPHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGLCKYRDCKHDTDPGCAIREAVEEGKIAETRFENYHRILESMAQVKTRKNFSDTDD
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_CHLL3
Sequence: MKRDYYEVLGVSRSADKDEIKKAYRKLALKYHPDKNPDNKDAEDHFKEVNEAYEVLSNDDKRRRYDQFGHAGVGSSAASGGGGGQYGGGADFSDIFSAFNDMFGGGGGGSQRRRAASGIPGVDLKIRLKLTLEEIAKGVEKTIKIKKQVPCKECNGSGSKTGATETCPTCHGAGEVRQASKTMFGQFVNIAACPTCGGEGRIVKDRCPSCYGEGIKQGEVTVKVNVPAGVQEGNYLTLRGQGNSGPRGGAPGDLIVMIEEKPHELFVRNGDDVIYSLAVSFPDLVLGTKVDVPTLEGAVKLTIPAGTQPETMLRIPGHGIGHLRGSGKGDQYVRVNVYVPKELTQQDKDLLRDLRKSPSIAPEAHSAGGAKSFFEKARDIFG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3137_YERPG
Sequence: MAALDPTLLILLALAALGILSHNMTVTLAILILIAIRITPLNSFFPWVEKYGLTIGVLILTIGVMAPIASGKISASEVLHSFVQWKSILAIVVGVAVSWLGGRGVSLMTHQPSVVAGLLVGTVLGVALFKGVPVGPLIAAGLLSLVIGKS
What are the official names of this protein?
UPF0756 membrane protein YpAngola_A3137.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: 3SA1_NAJSU
Sequence: MKTLLLTLVVVTIVCLDLGYTLKCNKLVPLFYKTCPAGKNLCYKMYMVATPKVPVKRGCIDVCPKSSLLVKYVCCNTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pores in lipid membranes (By similarity).  Exhibits concentration-dependent growth inhibitory effects in the lung cell lines A549 (IC(50)= 0. 88) and NL20 (IC(50)= 1. 91), in the prostate cell lines PC-3 (IC(50)= 3. 13 ug/ml) and RWPE-1 (IC(50)=0. 35 ug/ml), and in the breast cell lines MCF-7 (IC(50)= 9. 10 ug/ml) and 184B5 (IC(50)=6. 21 ug/ml), with high selectivity for the lung cancer cell line A549 (selectivity index=2. 17) (PubMed:33263003).  Induces primarily necrosis in the A549 lung cancer cell line, and mainly caspase-independent late apoptosis in the breast cancer cells line MCF-7 and in the prostate cancer cell line PC-3 (PubMed:33263003).
What are the official names of this protein?
Cytotoxin 1, CX1, Cardiotoxin-1, CTX-1, CTX1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: PINS_FRAVE
Sequence: MPVHATPAAESQIISKPEVVRRTANFKPSVWGDRFANYAEDIITQTQMQEQVEELKQVVRKEVFTNAADDSSHQLKLIDEIQRLGVAYHFESEIDQALERIHETYQDIHDGGDLYNVALRFRLLRRHGYNVSCDVFNKFKDTNGDYKKSLVTDLSGMLSFYEAAHLRVHGEKLLEEALVFTTTHLQSASAKSSLLKTQITEAVERPLLKTMERLGARRYMSIYQDEASYSENLLKLAKLDFNVVQCLHKKELSDILRWYKELDFARRMPFARDRIVELFFWIAGIYFEPEYVFGRHILTKLIEITTVMDDMYDAFGTFEELVILTEAIDRWDASCMDQLPDYMQPFYITLLDVIDEVEEELTKQGRSYRIHYAKEIMKNQARLYFAEAIWFHEGCTPKMDGYMRVAASSVGNTMLSVVSLVGMGDIITKFEFEWLTNEPKILRASNTIFRLMDDIAGYKFEKERGHVASSIDCYMNEYGVSEQETIDIFNKRIVDSWKDINEEFLRPTAAPVPVLNRVLNLTRVVDLLYKRGDAFTHVGKLMKDCIAAMFIDPVPL
What is the function of this protein?
Monoterpene synthase catalyzing the production of (-)-alpha-pinene, beta-phellandrene and beta-myrcene as the major products.  Unable to use farnesyl diphosphate as substrate.  Exclusively expressed in the fruit of wild strawberries.  Not detected in cultivated varieties.
What are the official names of this protein?
(-)-alpha-pinene synthase, FvPINS.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MSRP_SALTI
Sequence: MKKIRPLTEADVTAESAFFMQRRQVLKALGISAAALSLPSTAQADLFSWFKGNDRPKAPAGKPLEFSQPAAWRSDLALTPEDKVTGYNNFYEFGLDKADPAANAGSLKTEPWTLKISGEVAKPFTLDYDDLTHRFPLEERIYRMRCVEAWSMVVPWIGFPLYKLLAQAQPTSHAKYVAFETLYAPDDMPGQKDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPIRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLSAPNEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYANEVASLYRGLNLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.