PharMolix/UniProtQA huggingface dataset:
Protein: B9D1_DANRE
Sequence: MTSNNPAVFLLMVNGQIESADFPEYDDLYCKYCFVYGHDWAPTSGLEEGISQITSKGRLSQSLVWNFPLDITFKSTNPFGWPQIVVSVYGPDTFGNDVVRGYGAVHIPFTPGKHTKTIPMFVPESTSRLQKFTSWLMGRRPEFTDPKVVAQGEGREVTRVRSQGFVTLQFNIVTKDMKKLGYDTTSTEHSPAGLTRASQQL
What is the function of this protein?
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
What are the official names of this protein?
B9 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the B9D family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Protein: SAES_STAA8
Sequence: MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
What is the function of this protein?
Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion.  Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR.  SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, hlb), coa, Dnase, spa and cell wall-associated proteins (emp, eap, fnbA).  Acts probably downstream of the agr system in the regulatory cascade of virulence factors.
What are the official names of this protein?
Histidine protein kinase SaeS, Sensor protein SaeS, Staphylococcus exoprotein expression protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NDK_SYNP2
Sequence: MERTFVMVKPDGVQRGLVGDVIRRFEAKGFKLVGLKLVSVSRELAEQHYGVHRERPFFGSLVEFIISVPVVAMVWEGKGAIAAARKIIGATNPLEAEPGTIRGDFGVDIGRNLIHGSDGPDTAASEIALWFSESELANWEPATKAWLYE
What is the function of this protein?
(Microbial infection) Catalyzes the phosphorylation of dZDP to dZTP, when the bacterium is infected by a phage that produces the substrate for the synthesis of dZTP (2- amino-2'-deoxyadenosine 5'-triphosphate), which is then used by the phage as a DNA polymerase substrate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBE_EUCGG
Sequence: MSGSTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTESRQGIPLITGRFDPLEQLDEFSRSF
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: VLP23_BORHE
Sequence: MRKRISAIIMTLFMVLVSCNSGGVAEDPKTVYLTSIANLGKGFLDVFVTFGDMVAGAFGIKADTKKSDIGKYFNDIEKTMTTVKKRLQDEVAKNGNYVKVKEVVDKFVADVLDKIAAGAKKQLRATGDAAIGMLLNEDAAPAEVASVNSLVKGIKEIVGVVLKDNEGDAAATKTADAEKKSVGKLLGKGAADGTETQAAAASASIGAITGADILQAIAKSGKAGAGEIKIEEAKNAAEIAAAKADSKDLAIDSAKKDAVIAAGIALRAMAKDGKFAAKNNEEKSANAVNGAAASAVGKTLSTLIIAIRNTVDSGLKTINEALATVKQEDKSAEATNPAEATTSGQ
What is the function of this protein?
The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time.  Switching between these genes is a mechanism of host immune response evasion.
What are the official names of this protein?
Variable large protein 23.
What is the protein family that this protein belongs to?
Belongs to the variable large protein (Vlp) family. Delta subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RS8_STAES
Sequence: MTMTDPIADMLTRVRNANMVRHEKLELPASNIKKEIAEILKSEGFIKNVEYVEDDKQGVIRLFLKYGQNNERVITGLKRISKPGLRVYAKANEVPKVLNGLGIALVSTSEGVITDKEARKRNVGGEIIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SIRB2_SALTI
Sequence: MTIAMLLTLHLICVALSVSLFVARYWWRYCGHALAAARWTRIVPPVIDTLLLLSGIGLIVKTHILPFTESGSWLTEKLFGVIIYIVLGFIALDYRQARSQQARFIAFPLALVVLYIIIKLATTKIPLLG
What is the function of this protein?
Required for maximal expression of sirC, not required to invade host cells.
What are the official names of this protein?
Protein SirB2.
What is the protein family that this protein belongs to?
Belongs to the SirB2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FAM3D_MOUSE
Sequence: MRVAGLIRVVVFIFTIVTMWVFLRSYTSFSRKTIRLPRWLGITPKDIQTPKSKCGLSKICPNNFFAFKISSGAANVVGPSMCFEDEIIMSPVRNNVGRGLNVALVNGSTGQVMKKDSFDMYSGDPQLLLNFLTEIPDSTLVLVASYDDPGTKMNDKIKTLFSNLGSSYAKQLGFRDSWVFVGAKDLKSKSPYEQFLKNNPETNKYDGWPELLELEGCVPRKVM
What are the official names of this protein?
Protein FAM3D, Oncoprotein-induced protein 1, Protein EF-7.
What is the protein family that this protein belongs to?
Belongs to the FAM3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NQO2_MOUSE
Sequence: MAGKKVLIVYAHQEPKSFNGSLKKVAVEELSKQGCTVTVSDLYSMNFEPRATRNDITGAPSNPDVFSYGIETHEAYKKKALTSDIFEEQRKVQEADLVIFQFPLYWFSVPAILKGWMDRVLCRGFAFDIPGFYDSGFLKGKLALLSLTTGGTAEMYTKDGVSGDFRYFLWPLQHGTLHFCGFKVLAPQISFGLDVSSEEERKVMLASWAQRLKSIWKEEPIHCTPPWYFQE
What is the function of this protein?
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
What are the official names of this protein?
Ribosyldihydronicotinamide dehydrogenase [quinone], NRH dehydrogenase [quinone] 2, NRH:quinone oxidoreductase 2, Quinone reductase 2, QR2.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK33_GUIAB
Sequence: MAKGKDVRIPVLLECTACVRNGVNKESTGISRYITQKNRHNTPNRLELLKFCPYCYKHTIHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RF2_XANC5
Sequence: MIETNPIRQRITDLNDRVLSLRGIFDYDAKKERLEEVSRELESPDVWNDAERAQALGRERSMLEKTVIGIADVLSGLADAGDLLELAESEQDEDTALAVIADLDNYQAHVEKLEFQRMFSGQMDSANAFVDIQAGAGGTEAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDNIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRNAEKDALEATKSDIGWGSQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEASLKAGLAAGSKRLDA
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECX_CLOBA
Sequence: MAKITKLEVQKRNKERVNVFLDEDYAFSISAELIYKEGIKVKDSVDSEKLKVLANKDAIIKCREAAIKSIERNLKTEKQVRDKLNLKGYDEEAITKAIDFLKEYNFLDDKDYANKFVKDKLKCQGSNKIRYSLMQKGVSKDVIEEELSGIDKENEKENALVLAQKKVNNLRKTESDTYKISNKLYRFLLSKGYGYDIIKDVVKEAMNFEFYD
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LT_POVBG
Sequence: MDRVLSRADKERLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMNLGGTGFQGSPPRTAERGTEESGHSPLHDDYWSFSYGSKYFTREWNDFFRKWDPSYQSPPKTAESSEQPDLFCYEEPLLSPNPSSPTDTPAHTAGRRRNPCVAEPDDSISPDPPRTPVSRKRPRPAGATGGGGGGVHANGGSVFGHPTGGTSTPAHPPPYHSQGGSESMGGSDSSGFAEGSFRSDPRCESENESYSQSCSQSSFNATPPKKAREDPAPSDFPSSLTGYLSHAIYSNKTFPAFLVYSTKEKCKQLYDTIGKFRPEFKCLVHYEEGGMLFFLTMTKHRVSAVKNYCSKLCSVSFLMCKAVTKPMECYQVVTAAPFQLITENKPGLHQFEFTDEPEEQKAVDWIMVADFALENNLDDPLLIMGYYLDFAKEVPSCIKCSKEETRLQIHWKNHRKHAENADLFLNCKAQKTICQQAADGVLASRRLKLVECTRSQLLKERLQQSLLRLKELGSSDALLYLAGVAWYQCLLEDFPQTLFKMLKLLTENVPKRRNILFRGPVNSGKTGLAAALISLLGGKSLNINCPADKLAFELGVAQDQFVVCFEDVKGQIALNKQLQPGMGVANLDNLRDYLDGSVKVNLEKKHSNKRSQLFPPCVCTMNEYLLPQTVWARFHMVLDFTCKPHLAQSLEKCEFLQRERIIQSGDTLALLLIWNFTSDVFDPDIQGLVKEVRDQFASECSYSLFCDILCNVQEGDDPLKDICEYS
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription.
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RS7_ALKEH
Sequence: MPRRREVPKRKVLADPKYGSELLTKFVNMVMRDGKRSVAEKIMYGALERIESKGHETPMEVLETALENVQPKVEVKSRRVGGATYQVPVEVRPERRTTLAMRWLLDAARKRGETTMALRLAGEMLDASESRGAAVKKREDTHRMAEANKAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: POTA_PSEF5
Sequence: MNALHALQTLAVSIRSVRKVYGDPHSGPVALKNIDLDIRDNEFFTLLGPSGCGKTTLLRMIAGFEFPTQGEILLYGENIADRPPFERPVNTVFQHYALFPHMTLAENLAFGLESRPMGQVLSKAQIDERVREMLALVQMERFAARKPNQLSGGQQQRIALARALAPHPKVLLLDEPLSALDLKLRQAMREELKAIQAKTGITFIFVTHDQEEALTLSDRIAVLSEGEVQQVGRPEEIYEQPRNRFVADFIGETNFIPAMVSRVEAGLAWFSGPAGQALPAQPCTTAKVGQQVTLSVRPERLHLRGDASQGALACRIEALIYLGTDLQYQVSLGDGTRLTVRTPNSLEHHPRLSVGSSAGLLFERGSASVLLD
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BPT_RHOPB
Sequence: MTQHSRDTPQFYLTAPSPCPYLPGRHERKVFTHLVGGKAGELNDLLTHGGFRRSQSIAYRPACDQCRACVSVRVVANEFRASRGQRKILARNADVIGELRSAVPTSEQYSVFRAYLDRRHRHGGMADMTVLDYAMMVEDSHVKTRIIEYRRRGPDSGITGRGEDLLAVALTDILNDGLSMVYSFFEPGEDSRSLGTFMILDHIARARRLGLPYVYLGYWIEGSKKMDYKGRYLPQQRLAPSGWIRVDASGESAVEPQD
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_CHLAD
Sequence: MNEQTILGLDVGERRIGVAISDVEARIAAPLTTIPAHPPERAIAQIARLVAERGVRRVVVGLPLTMRGEHGPQAAAIQRFVDALAAVLNCPVEMFDERLTSVAAEQMLRNLGVKPAKIKEQIDQVAASIILQDYLDARRNPF
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDH_STRGG
Sequence: MKALVKQKAEPGLWLMDVPEPEYGPTDVLIKVLRTGICGTDLHIRAYDGWAQQAVTTPLILGHEFVGEVAAIGSDVADIATGDLVSGEGHLVCGKCRNCLAGRRHLCRSTVGLGVGRDGAFAEYVVLPASNVWVHRVPVDLDIAAIFDPFGNAVHTALSFPLVGEDVLITGAGPIGIMAAAVARHAGARNVVITDVSEARLALARKVGVSLALNVADRTIADGQRELGLREGFDIGLEMSGRPEAMREMVANMTHGGRIAMLGLPAEEFAVDWARIVTSMITVKGIYGREMYETWYAMSVLLEGGLDLAPVITGRYGYRDFEAAFDDAASGLGGKIILDWTV
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THYX_TROW8
Sequence: MFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCLSNRDIGLITFLMRERHGSPFEHSHMTFRISAPIFVFREFMRHRIASYNEESGRYKNLDPVFYIPDEKRKLVQIGAPGAYKFEEGTSEQYGLLIEEMKELSLAAYDTYKRLLACGIAREVARMILPLNLYSTMYVTINARSLMNFLSVRTSRANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: SCS7_YEAST
Sequence: MSTNTSKTLELFSKKTVQEHNTANDCWVTYQNRKIYDVTRFLSEHPGGDESILDYAGKDITEIMKDSDVHEHSDSAYEILEDEYLIGYLATDEEAARLLTNKNHKVEVQLSADGTEFDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSKMKYE
What is the function of this protein?
Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids (PubMed:9353282, PubMed:9368039, PubMed:26977056, PubMed:9559540, PubMed:16652392, PubMed:19074599).  Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2 (PubMed:9368039, PubMed:26977056).
What are the official names of this protein?
Ceramide very long chain fatty acid hydroxylase SCS7, Ceramide VLCFA hydroxylase SCS7, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase SCS7, Dihydroceramide fatty acyl 2-hydroxylase SCS7, Sphingolipid alpha-hydroxylase, Suppressor of calcium sensitivity 7.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family. SCS7 subfamily.
Protein: BIOH_ECO57
Sequence: MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLAEMAEAVLRQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRLPLQNVPMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHPVEFRHVLVALKQRV
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_CLOP1
Sequence: MGKFEDKKQLRCSFCGKNQEQVKRLIAGPGVYICDECIELCSEIIEDEFEGNTESSPLEASNLPKPQEIKDYLDQYVVGQDRAKKSLAVAVYNHYKRINANKAEDDVELQKSNILLLGPTGSGKTLLAQTLAKMLNVPFAIADATTLTEAGYVGEDVENILLKLIQNADYDVERAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQINTSNILFICGGAFDGIDKIIEKRGTKSSIGFGAEVKGKSEKNVGELLKDIMPGDLLKFGLIPEFVGRLPVLVTLEALDNEALVSILTKPKNALVKQYKKLFELDNVKLDFTEEALKAIADEAINRKTGARGLRAIVEETMMDIMFDIPSEENIVKATITEETIKDRKDPELEKLPEGEVRPTLKTEKKNKARKDIETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: DTWD2_MOUSE
Sequence: MEPQAEERTLGEPAPPPSGALASPTPDEEERTEGGAPPTATPAGASGDSTSADGLWGLPVEHAERRPECGRCSRPQKVCLCPYLPVRPLQISTHLYIIQHPAEESRVLRTVPLLAACLPPDRCTVKIGRRFSEERDVELATVCRDSGTLILYPGAEATNLEEFILDSPVYPSTIILIDGTWSQAKDIFYKNSLFRLPKQVQLKTSVCSQYVIRMQPTNRCLSTLECAAVALSILEKNNCIQETLLRPLQALCSFQLQHGAQIRLSKEYLLRNGLYPKPMPKNKRKLRKMELLMNSVKI
What is the function of this protein?
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)).  Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)).
What are the official names of this protein?
tRNA-uridine aminocarboxypropyltransferase 2, DTW domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. DTWD2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: REX_RHOBA
Sequence: MFQSQRLCGWIMNMNTDHETSDSGGSDEGDRRAELSTPAVGRLSLYYRELHRLLAAGESSTNSRDLGAMVNVSPAVVRRDLSSIGSIGRRGVGYDVAILAERIGAVLGSGVQWKAVLIGVGSLGNALLRYRGFERLGFSLAAAFDTDPAKYGHEVGGTTVRSLDDLEEVLATAKPELAILAVPSEQASQVATRVLAGGIQGILNFAPTTLRVPPGTAIINVDLASELQQLAFRIQNR
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KILR_ECOLI
Sequence: MIAHHFGTDEIPRQCVTPGDYVLHEGRTYIASANNIKKRKLYIRNLTTKTFITDRMIKVFLGRDGLPVKAESW
What is the function of this protein?
Causes inhibition of cell division.  At high levels of expression, can also abolish the rod shape of the cells.  Division inhibition by KilR can be relieved by overexpression of the cell division protein FtsZ.
What are the official names of this protein?
Killing protein KilR, FtsZ inhibitor protein KilR.
Protein: LICT_BACSU
Sequence: MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARIEKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHINFAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHIVNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNGTHMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQA
What is the function of this protein?
Mediates positive regulation of the glucanase operon (licST) by functioning as an antiterminator factor of transcription.  Prevents termination at terminator lic-t.
What are the official names of this protein?
Transcription antiterminator LicT.
What is the protein family that this protein belongs to?
Belongs to the transcriptional antiterminator BglG family.
Protein: RF1_METKA
Sequence: MAESSTVERYRFRKMIERLENLRGQGTELITIYIPPENRLSDVIAQMREEYSQASNIKSKRTRKNVQSAIEVVMQRLKMVGETPENGLVVLVGTVQDGTKEKMVAELIEPPEPVDRFIYRCDSKFYLEPLKEYLEEKDVYGILVMDRREATIGLVKGKRIEPVKRLTSDVPGKHKAGGQSQRRFDRLIEHAAHEFYQKVGEAAREAFEDVKDLKGIIVGGPGPTKEEFLDGDYLPKDLKEKVLTVVDVGNTDESGLREALNKAEEALKEAELVREKRLVRKFMEEAVNGELAAYGEEVDELLKMGAVEVLLVSEDLEGYKVILRCPECGYENIVTVKEKDEAKKYVEECPECGEAELNVEEIKDIVDYYVELAEQMGSNVEIISTETEEGAQFYNAFRGLGALLRFRPK
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Peptide chain release factor subunit 1, Translation termination factor aRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSRA_ACTP2
Sequence: MLILTRKIGESLLIGDNVEITVLSVRGNQVKLGVNAPKEVSVHREEIYQRIKALADDVASDTQQ
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.