PharMolix/UniProtQA huggingface dataset:
Protein: LDH_LIGS1
Sequence: MSKTQNHQKVILVGDGAVGSSYAYAMALQGTAEEFGIVDVVKERTEGDALDLFDATGFTFPKKIYAAEYSDCKDADLVVITAGAPQKPGETRLDLVNKNLKILSSIVKPVVESGFDGIFLVAANPVDILTYATWKFSGFPKEKVIGSGTSLDTARLRVAMTEMTGIKDPRSMHAYIMGEHGDSEFAAYSAATIGGRPFLDWAKEHGVSKEDLDKMEDDVRNKAYEIINKKGATFYGVAAALARISKAILRDENAVLPVSAYMEGQYGLNDIFIGTPAVVNGTGLHEVIEVPLNEEESKKMTESAATLKKVLTDGLKALEENK
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_COLP3
Sequence: MTTATKDLSSHTPMMRQYLTIKAEFPHTLIFYRMGDFYELFFDDAKKASDLLDISLTARGKTGGNAIPMAGVPYHAAENYLAKLVALGESVAICEQIGDPATSKGPVERKVVRVITPGTVSDEALLVDRQDNLIVAIVDNQSPNAKLKTSSAPAFGLAYLDMASGRFVLTEPQTAEQLQAELQRLSPAELLYSESLQDFSLIEQRKGLRRRPEWEFDLDTAISLLNKQFDTKELTGFGVDDKPLGLAAAGCLFQYVKDTQRTALPHIRAIVCESANKGVVLDAATRRNLELTQNLHGGLDNTLAAILDKSSTPMGSRLLKRWLHFPLRDLTVLNNRQNTVSDIIALDLIAPIQPLLKGLGDIERIVSRIALGSARPRDFARLRHALQQLPELQNELKSGLTESPTNYLATIAQQSQPMPQLEGLLVHAIVENPPVLIRDGGVIAPGYNNELDVLRDLSDGATEFLAQLEQREKERTGIHSLKVGYNRVHGFFIEMSRTAAVDVPDDYIRRQTLKNNERFITEELKQHEEKVLSAQSKFLALEKSLYQELFDKVLPDLAQLQQLSQAIAELDVLTTFAERALALNYVKPSLVEEPGISIDAGRHVVVEQMTNDAFIANPVLLTEQRKMLIITGPNMGGKSTYMRQTALIVLLAHIGCYVPADNATIGLVDRIFTRIGASDDLASGRSTFMVEMTETANILHNATDKSLVLLDEIGRGTSTYDGLSLAWACAEMLALKTKAFTLFATHYFELTLLAGQISTLANVHLDAMEHDDNIVFMHAVQEGAASKSFGLQVAQLAGVPKTVIKRAKQRLSELEQQQTPSILPAPIQNDAFEQLSFAPEEHSVVTTLIDTDINELSPRQALDLLFSLKEQL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: EIF3C_ASPOR
Sequence: MSRFFYGSGSDSDSSSDEEELLTDREEEEKSEEESSEEEEETSEEESSDDEGETGANRFLRDASESEESEDEEKVTVVKSAKDKRLEELEGIIKLIENAEKINDWAVISSEFDKLNRQVVKVTQSGPVPRIYVKAVADLEDFVNETITKQKSAKKMNASNSRGFNAVKQRIKKNNKEYATHIEKYRSDKDGYMEGKEEEAKPAIVAPRLTKVERVVEAPAAATSTDDGFATVGRGGKTLQYTPESILKHLRVIVESRGKKNTDRLEQIKTMEKLLEVAQTPYQRIRVYLTLLSTRFDISSTSSANYMSVDQWKLAEKELAALLSVLETNRDHVVTEGAEEWEDDEKQPQVKPGETLHIPGSIVSHVERLDDELTRSLQHIDPHTAEYIDRLSDEKQLYTNLVRVQAYIEGLVEAEKSDMRQDSLNRVVMRRLEHIYFKPSQVVTILEEGTWKALPSELDSKVTPRGNAGDVTGLVQTLCNYLFTYSDGIIRARAMLCQIYFLALHDQYYRSRDLMLMSHLTENISNFDVNTQILFNRTLVQIGLCAFRAGLIYEAQNTLSEVCGSGRQKELLAQGIILQRYSTVSPEQERLERQRQLPFHMHINLELLECIYLTSSMFLEVPLMAQTSSSPELKRRIISKTFRRMLDYNERQVFTGPAENTRDGVIMSAKFLAAGDWKKAAEMLNSIKIWDLMPQPDKIKEMLSQQIQEEGLRTYLFTYAPFYDSLSISTLSNMFELSEKKIAAIISRMISHEELAAALDQVNDAIVFRKGVELSRLQSQVVTLADKSMNLLEANEKTLEQRTQGMANAFQRDQGAGARGGRGPGRGGQARGGPRLPGGQQGRRPGGQQFSGGALGGAIKA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBP2_HORVU
Sequence: MRTTTRRLPPAPAAAAVLLAALTCLLLRPAAVAAAGGHAADRIVRLPGQPEVDFDMYSGYITVDEAAGRSLFYLLQEAPEEAQPAPLVLWLNGGPGCSSVAYGASEELGAFRVMPRGAGLVLNEYRWNKVANVLFLDSPAGVGFSYTNTSSDIYTSGDNRTAHDSYAFLAAWFERFPHYKYREFYVAGESYAGHYVPELSQLVHRSGNPVINLKGFMVGNGLIDDYHDYVGTFEFWWNHGIVSDDTYRRLKDACLHDSFIHPSPACDAATDVATAEQGNIDMYSLYTPVCNISSSSSSSSLSRRRTRGRYPWLTGSYDPCTERYSTAYYNRRDVQTALHANVTGAMNYTWTNCSDTINTHWHDAPRSMLPIYRELIAAGLRIWVFSGDTDAVVPLTATRYSIGALGLATTTSWYPWYDDLQEVGGWSQVYKGLTLVSVRGAGHEVPLHRPRQALILFQQFLQGKPMPGRTTNVTVA
What is the function of this protein?
May be involved in the degradation of small peptides (2-5 residues) or in the degradation of storage proteins in the embryo.
What are the official names of this protein?
Serine carboxypeptidase 2, CP-MII, Carboxypeptidase D, Serine carboxypeptidase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the endosperm.
Protein: PSBC_OLTVI
Sequence: METLFNGSLTVGGRDQESTGFAWWSGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHIASLGYGVGPGGEIIDTFPYFVSGVLHLISSAVLGFGGIYHALIGPETLEESFPFFGYIWKDKNKMTTILGIHLILLGFGAWLLVWKAMYFGGVYDTWAAGGGDVRIISNPTTNPGVIFGYLLKSPFGGDGWICSVDNMEDLIGGHIWIGTLEIFGGIWHILTKPWGWARRAFVWSGEAYLSYSLAAISAMGFIACCMSWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVASAQGPTGLGKYLMRSPTGEIIFGGETMRFWDFRGPWLEPLRGPNGLDLNKLKNDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINSINYVSPRSWLATSHFCLGFFFFVGHLWHAGRARAAAAGFEKGIDRDTEPVLSMKPID
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ILVC_NOSP7
Sequence: MARMYYDEDANLDLLAGKTIAIIGYGSQGHAHALNLKDSGLNVIVGLYPGSKSVAKAEAAGLTVKSVADAANAADFIMILLPDEVQKTIYKNEIEPNLEEGNVLAFAHGFNIHFGQVVPPANVDVVMVAPKGPGHLVRRTYEGGEGVPALFAVYQDASGQARDRAMSYAKGIGGTRAGVLETTFREETETDLFGEQAVLCGGLSALIKAGFETLVEAGYQPELAYFECLHEVKLIVDLVVEGGLAKMRDSISNTAEYGDYTRGPRIVTQQTKAEMQKILSEIQSGQFAREFVLENQSGKPGFTAMRRKESEHKIEEVGKDLRAMFSWLKKA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: S352B_HUMAN
Sequence: MSSSVKTPALEELVPGSEEKPKGRSPLSWGSLFGHRSEKIVFAKSDGGTDENVLTVTITETTVIESDLGVWSSRALLYLTLWFFFSFCTLFLNKYILSLLGGEPSMLGAVQMLSTTVIGCVKTLVPCCLYQHKARLSYPPNFLMTMLFVGLMRFATVVLGLVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGLLVNLSLIPVMGGLALCTATEISFNVLGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVAMLVPARVFFTDVPVIGRSGKSFSYNQDVVLLLLTDGVLFHLQSVTAYALMGKISPVTFSVASTVKHALSIWLSVIVFGNKITSLSAVGTALVTVGVLLYNKARQHQQEALQSLAAATGRAPDDTVEPLLPQDPRQHP
What is the function of this protein?
Putative transporter.
What are the official names of this protein?
Solute carrier family 35 member E2B.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35E subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GUAD_ECOLI
Sequence: MMSGEHTLKAVRGSFIDVTRTIDNPEEIASALRFIEDGLLLIKQGKVEWFGEWENGKHQIPDTIRVRDYRGKLIVPGFVDTHIHYPQSEMVGAYGEQLLEWLNKHTFPTERRYEDLEYAREMSAFFIKQLLRNGTTTALVFGTVHPQSVDALFEAASHINMRMIAGKVMMDRNAPDYLLDTAESSYHQSKELIERWHKNGRLLYAITPRFAPTSSPEQMAMAQRLKEEYPDTWVHTHLCENKDEIAWVKSLYPDHDGYLDVYHQYGLTGKNCVFAHCVHLEEKEWDRLSETKSSIAFCPTSNLYLGSGLFNLKKAWQKKVKVGMGTDIGAGTTFNMLQTLNEAYKVLQLQGYRLSAYEAFYLATLGGAKSLGLDDLIGNFLPGKEADFVVMEPTATPLQQLRYDNSVSLVDKLFVMMTLGDDRSIYRTYVDGRLVYERN
What is the function of this protein?
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
What are the official names of this protein?
Guanine deaminase, Guanase, Guanine aminase, Guanine aminohydrolase, GAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
Protein: NEUS_HUMAN
Sequence: MAFLGLFSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL
What is the function of this protein?
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376).  May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system.  May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
What are the official names of this protein?
Neuroserpin, Peptidase inhibitor 12, PI-12, Serpin I1.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon.
Protein: ARNB_ECO7I
Sequence: MSEFLPFSRPAMGVEELAAVKEVLESGWITTGPKNQALEQAFCQLTGNQHAIAVSSATAGMHITLMALEIGKGDEVITPSLTWVSTLNMISLLGATPVMVDVDRDTLMVTPEAIESAITPRTKAIIPVHYAGAPADIDAIRAIGERYGIAVIEDAAHAVGTYYKGRHIGAKGTAIFSFHAIKNITCAEGGLIVTDNENLARQLRMLKFHGLGVDAYDRQTWGRAPQAEVLTPGYKYNLTDINAAIALTQLAKLEHLNTRRREIAQQYQQALAALPFQPLSLPAWPHVHAWHLFIIRVDEQRCGISRDALMEALKERGIGTGLHFRAAHTQKYYRERCPTLSLPNTEWNSERICSLPLFPDMTTADADRVITALQQLAGQ
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: SUBI_ECOLI
Sequence: MNKWGVGLTFLLAATSVMAKDIQLLNVSYDPTRELYEQYNKAFSAHWKQQTGDNVVIRQSHGGSGKQATSVINGIEADVVTLALAYDVDAIAERGRIDKEWIKRLPDNSAPYTSTIVFLVRKGNPKQIHDWNDLIKPGVSVITPNPKSSGGARWNYLAAWGYALHHNNNDQAKAQDFVRALYKNVEVLDSGARGSTNTFVERGIGDVLIAWENEALLAANELGKDKFEIVTPSESILAEPTVSVVDKVVEKKGTKEVAEAYLKYLYSPEGQEIAAKNYYRPRDAEVAKKYENAFPKLKLFTIDEEFGGWTKAQKEHFANGGTFDQISKR
What is the function of this protein?
This protein specifically binds sulfate and is involved in its transmembrane transport.
What are the official names of this protein?
Sulfate-binding protein, Sulfate starvation-induced protein 2, SSI2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic sulfate-binding protein family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HPHL1_MOUSE
Sequence: MFLKQPGGCILLQFLGLLGLVGAVTRTYYIGIVEEYWNYVPQGKDVITGKSFSEDKLATLFLERGPNRIGGIYKKAVYRHFTDGSYSTEIPKPPWLGFLGPILRAEVGDVIVIHLMNFASRPFSLHPHGVFYDKDSEGALYPDGTSGRNKEDDMVPPGKNYTYVWPVREEYAPAPADANCLTWVYHSHIDAPKDICSGLIGPLLVCKEGVLNRYSGMRTDVDREFVIMFTLVDENQSWYLDDNIKQFCTNPNSVDKSDAVFQRSNKMHALNGFLFGNMPEPEMCVGESVSWHLFGMGNEIDIHSIYFYGNTFITRGHRADVVNLFPATFLTTEMIVENPGKWMITCQVSDHLQAGMLGQYSVGNCRGNAPHPKVQGQQRRYFIAAEKVLWDYGPQGYDKFTGFPLNTSGSDSAVYFTQADNRIGGKYWKARYTEYVDATFSRRKMPSDSEAHLGILGPVIKAEVGDILLVTFANKADKVYSILPHGVFYDKASDAAPNVDGFLKPGAHVKPGETFTYRWTVPESVSPTDEDPPCLTYLYFSAVQPIKDTSAGLVGPLLVCKKGTLNADGTQKGIDKEFYLLFTVFDENFSSYLDENIKKFTWHPFSVDKEDKEFVKSNRMHAVNGYMYGSQPGLSMCKKDRVSWHLIGMGTDTDMHGVYFQGNTIHLRGTHRDSLALFPHMATTAYMQPDHSGIFKVFCSTLPHFTRGMGQIYEISSCGNRDPSEPPYGMLRTFFIAAEEVEWDYAPNKNWEFEKQHLDAGGERHGDIFMNHTENWIGSQYRKVVYREYTNGEFVEIKARPPQEEHLQLLGPMIHAEVGDSILIIFKNKASRPYSIAAQGVEDSNNGKLLNVPVTKPGEIKTYRWNVPKRSGPGPSDPNCIPWVYFSTANFVKDTYSGLMGPLITCREGVLNEKGRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKHTDDFEESNKMHAINGKIFGNLPGLIMTEDSMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSYREDVYDLFPGTFQTIELFADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNRIPYSTKTPSGAGSHAVTVPSQEQPGKEELYFFGKNLRPRGAKAALVILFILGLLLLVATVVLALRLRSSRRQMAYREVQSCALPTDAL
What is the function of this protein?
Is a copper-binding glycoprotein with ferroxidase activity.  It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species.  May be involved in the regulation of intracellular iron content.
What are the official names of this protein?
Ferroxidase HEPHL1, Hephaestin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MSX1_CHICK
Sequence: MGGEEESDKPKVSPSPLPFRRWKGSWPTAERGRQRRSRGFRAPSRRPSQPRRSDDGGTDVAAPSRRPLPVRRGAGQAARGRAAQSREPREAGATPWMQSPRFSPPPPRAEPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGISFPLGGPAVAGASLYGASSPFQRAGLPVAPVGLYTAHVGYSMYHLT
What is the function of this protein?
Probable morphogenetic role.
What are the official names of this protein?
Homeobox protein MSX-1, Homeobox protein Hox-7, CHOX-7, Msh homeobox 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the Msh homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TM6S1_XENTR
Sequence: MSAPAATGVFILSLTAIPATYTFNFFFAFNSSWPVAAGGAGILLVIAILARLLVIQKPPKDPLFYVYAVFAFTSVIGLIIGLEQDGIIDGFMTHYLKESEPYLNTAYGHMICYWDGTAHYLMYLLMVVAIAWDQNYRTIGLYWVGSILMSTIVFIPGNIVGKYGTRVCSALLLNLPYLCLPLWAGFKIYKQPSVTPNYSSKEIQNIQHKSIYRRPSDLLLALYLILATLFCIFRGMIALDCPADPCRFYIQLQEPYIKDPSAYPRLQMLVLMFYCVPYNLILLYGLLVPECTWMPDLSLISAGGIAQAQFSHIGASLHARTPYIYRVPDEARIFFFTANILYGLGSQLLAHRCVNKPEFFLKAKSGAKDK
What is the function of this protein?
May function as sterol isomerase.
What are the official names of this protein?
Transmembrane 6 superfamily member 1.
What is the protein family that this protein belongs to?
Belongs to the TM6SF family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein.
Protein: RFCL_SULIA
Sequence: MIQWFLKYRPRSLKDVENQDGAKKELQEWIESWLNGKPNAKAVLLHGPPGVGKTTLAEALAHDYNLELLEMNASDSRKLQDIKSVAEKASVYGSIFGTRGKLILLDEVDGINVREDTGAIQGILELIEKTKYPLIMTANDPWNPALRELRNKTKMVGLNKLGKYPLRRLLKKICQAEKIICDDEALNYIIDTSEGDARYAINMLQGIGEGYGKVTLDLVEAMARRKERELDPFETLRDIFWARYAWQAKNAATSAQIDYDMLIRWISENIPIQYDNIEDVWRAFDALSRASIFLKRAKGGDWDLLSYAYDLMSSGVAAAEIEKKKPNWKPKWKKYQFPSYIQLLSKSKDIRDTRDEIIKKLAIHSSFNKTLNDTYPFFLIFYKKYDKRLSLNTKEKEYLNSASKS
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C large subunit, RFC large subunit, Clamp loader large subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcL subfamily.
Protein: RMLD_ECOLX
Sequence: MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPEGVAETVKKIRPDVIVNAAAHTDVDKAESEPEFAQLLNATSVEAIAKAANEVGAWVIHYSTDYVFPGTGEIPWQGGTDATAPLNVYGETKLSSEKKALQKHCGKHIIFRTSWVYAGKGNNFAKTMLRLAKEREELAVINDQFGRPTGAELLADCTAHAIRVAVDKPEVAGLYHLVAGGTTTWHDYAALVFEEARKAGINLALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFALVLPDWQVGVKRMLNELFTTTAI
What is the function of this protein?
Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS) (PubMed:7559340).  Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose (By similarity).  RmlD uses NADH and NADPH nearly equally well (By similarity).
What are the official names of this protein?
dTDP-4-dehydrorhamnose reductase, dTDP-4-keto-L-rhamnose reductase, dTDP-6-deoxy-L-lyxo-4-hexulose reductase, dTDP-6-deoxy-L-mannose dehydrogenase, dTDP-L-rhamnose synthase.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose reductase family.
Protein: Y1138_MYCLE
Sequence: MTTPAQDAPLVLPAVAFRPVRLFIINIVLTGLAMLAAGLSGHLMVGVFFGIGLLLGLLNALLVRCSVESITAQGHPLKRSMALNSASRLAIITVFGLIIAYAFPLAGLGVVFGLALFQVLLVLSTMLPVWRKFRFGEADGGVLKGSEGEEQQR
What are the official names of this protein?
Uncharacterized protein ML1138.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1303.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL6_GEMAT
Sequence: MSRIGKRPIPVPAGVTVAIDGSAVTVKGPKGELSRVLPADIVVSQEGAELLVKRPSDEERHKALHGLTRTLVANMVEGVTTGFKRVLEITGVGYKAEIKPYGALLSLGFSHQIEYKAPQGVQITAPNPTTVVIEGASKEHVGQVAAEIRSLRKPEPYKGKGVKYQGEVVRRKAGKAGGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: C5I1_RHIAP
Sequence: MNAMLVLFIASALFISEHNTEEVKTTPIPNHQCVNATCERKLDALGNAVITKCPQGCLCVVRGASNIVPANGTCFQLATTKPPMAPGDNKDNKEEESN
What is the function of this protein?
Complement inhibitor (PubMed:27018802).  Prevents complement-mediated C5 activation by binding to C5 (PubMed:27018802).  Binds C5 at a different binding site than the other tick complement inbibitors OmCI and CirpT1, and the drug eculizumab (By similarity).  Inhibits the complement in human and guinea pig but not in other species tested (rabbit, rat, mouse, and pig) (PubMed:27018802).
What are the official names of this protein?
Complement inhibitor RaCI1, Rhipicephalus appendiculatus complement inhibitor 1.
What is the protein family that this protein belongs to?
Belongs to the RaCI family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYSP3_SOLLC
Sequence: MSRLSLVLILVAGLFATALAGPATFADKNPIRQVVFPDELENGILQVVGQTRSALSFARFAIRHRKRYDSVEEIKQRFEIFLDNLKMIRSHNRKGLSYKLGINEFTDLTWDEFRKHKLGASQNCSATTKGNLKLTNVVLPETKDWRKDGIVSPVKAQGKCGSCWTFSTTGALEAAYAQAFGKGISLSEQQLVDCAGAFNNFGCNGGLPSQAFEYIKFNGGLDTEEAYPYTGKNGICKFSQANIGVKVISSVNITLGAEYELKYAVALVRPVSVAFEVVKGFKQYKSGVYASTECGDTPMDVNHAVLAVGYGVENGTPYWLIKNSWGADWGEDGYFKMEMGKNMCGVATCASYPIVA
What are the official names of this protein?
Cysteine proteinase 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Vacuole.
Protein: PYRB_ECO24
Sequence: MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLDPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: DKC1_MOUSE
Sequence: MADAEVITFPKKHKKKKDRKPLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE
What is the function of this protein?
Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:12522253, PubMed:15240872).  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs (PubMed:12522253, PubMed:15240872).  Required for ribosome biogenesis and telomere maintenance (By similarity).  Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit DKC1, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Protein: GLND_VIBC1
Sequence: MTLQSPLTFRDEQINIGELKQELEKFSSYQKEEFLQHHPVTNLVLSRAEYMDLLLNRLWQHFGFKDIHNISLVAVGGYGRGELHPLSDIDILILSNNKLPNALEAKISEFITLLWDLRLEVGHAVRTVDECAEIGRADLTVATNLQEARLLCGSEDTFQALKKVVLSDSFWPSETFYRAKIQEQRERHARYHDTTYNLEPDIKSTPGGLRDIHTLSWVARRHFGATSLLEMSRYGFLTDAEYRELVECQDILWRVRFALHIELRRYDNRLTFAHQAQVAEHLGYVGEGNRGVEMMMKEFYRTLRRVAELNKMLLKLFDQAIINGGASEDAEIIDEDFQRRGALIEARKPALFQARPETILDMFLHIANDSSIEGVSPPTLRQLRTARRRLNKFLHTIPEAREKFMALCRHPNALHKAFSLMHKLGVLAAYLPQWSQIVGQMQFDLFHVYTVDEHSIRLLKHINTFSYAENHSKHPICCEVYPRIQKKELLILAAIFHDIGKGRGGDHSVIGEGEAYDFCIEHGLSKPEAKLVSWLVRHHLLMSVTAQRRDIYDPDVITEFAKQVRDEEYLEYLVCLTVADICATNPELWNSWKRTLLAELFYSTQRALRRGLENPVDVRERIRHNQQMASAQLRKEGFSAREIEVLWQRFKADYFLRHTHKQIAWHCENLLRMEDTSKPLVLISKKATRGGTEVFVYSPDQPALFATVVAELDRRNFNVHDAQIMTSKDGYVLDTFMVLDQHGKAIEEGRHSAVTKHITHVLEDGRPTKIKTRRTPNKLQHFNVKTKVDFLPTKSKKRTLMEFVALDTPGLLAKVGRTFADLGINLHAAKITTIGERAEDLFILTSEAGGRLSEEQQTELREKLIEKLSDSVSA
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: ORF3_TTVI1
Sequence: MKEKDYWEEAWLTSCTSIHDHHCDCGSWRDHLWTLCALDDADLAAAADIIEREEADGGEDFGFVDGDPGDAGGSAACTSLPPESKIPALLTRPILSEWSEQLHTPNTPGKAESRPKLEIKVSPLPLSVPSVQLHQIPTRSRRSSKPRKPRKKRKERVRPVSRVPKALLREMDRLMTKQRDALPESESSSYFSSDSLTDPWTTSDDDFQSDPDPLTNKRKKRLQF
What are the official names of this protein?
Uncharacterized ORF3 protein.