PharMolix/UniProtQA huggingface dataset:
Protein: SSB_COREF
Sequence: MAQGDTNITVVGNLVADPELRFTPSGAAVANFRIASTPRTFNRTTNQWEDGEGLFLTCNVWREAAENVAESLTKGMRVIVQGRLRQRSYETREGEKRTIFEVEVDDVGPSLKYAKAEVTRIPRGGGQGGFGGNQGGGFGGQGGNQGGNPGGGQGGFGQNTGGFGGQQGNQGGFGGGQGGNPGGNQGQSGNNFNQGGFGGGGNQAAAPDNDPWNSAPPAGSGGFGGADDEPPF
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: CP2B4_RABIT
Sequence: MEFSLLLLLAFLAGLLLLLFRGHPKAHGRLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFPGFLKHFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.  In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin.
What are the official names of this protein?
Cytochrome P450 2B4, CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: YFI3_SCHPO
Sequence: MSLKPVKLAFEKYSATVAKHPPVLIFHGLLGSKRNWRSLAKKFSCKLDRDIYAIDQRCHGDSPCVAPLSYSAMALDAFQFMKDHKLDKASIIGHSMGAKTAMVTALKWPDKVEKLVVVDNSPWYQDLPRDYGAYFRKMIQIDEANITKYSEADKMMSTVEKDILVRSFLLSNLKKDSNNSNTFKFRVPIELISKSLKTIEGFPASLNDLVYDSPTLVIRALKAPFIPDSALPVFKKFFPKYELVSLDCGHWVHFEKPKEFSESIINFLNN
What are the official names of this protein?
Abhydrolase domain-containing protein C22H12.03.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MQO_CHRSD
Sequence: MVGTHMDESVDIVLVGAGVMSATLATLLHELEPDARIEIIERLDSTASESSFAWNNAGTGHAGLCELNYTPRADDGSISLDKAIHTNTLFEESKQFWSYLVEKGNLGDPGRFVHPVPHMSFVRGEDDVRFLRDRYHAMREHPCFEGMEYTEDRSVIGQWAPLLLDGREGDEPLAATRVATGTDVDFGALTRQLLARLEEKPDEQVRITTGQTVEDLTRNEDGSWRIKIAGNDDTQRTLNARFVFLGAGGASLHLLQKSGIPEGKGYAGFPVSGQWLRCDKPEIVSRHNAKVYSKAPIGAPPMSVPHLDTRNVDGSPSLLFGPFAGFTTKFLKTGSVMDLAKSVRSSNLSPMLSVARDNFSLVKYLIDQVRLSHEQRVDELRTFYPMAKNDDWRLEVAGQRVQVIKKDPQKGGILQFGTEVVAASDGSLAALLGASPGASTATSIMLNLVEQCFPEKFASQAWQQRLHDLVPARAETLADNGDLLRDVRRRTHDTLKLVDTQPSPEPVT
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: ABHD6_RAT
Sequence: MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSVLMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGNVAGVYAAYYPSDVCSLSLVCPAGLQYSTDNRFVQRLKELEDSAATQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVSEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSITNSQVEVLENCGHSVVMERPRKTAKLVVDFLASVHNPDNNKKLN
What is the function of this protein?
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity).  Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways.  Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).  Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism.  BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity).
What are the official names of this protein?
Monoacylglycerol lipase ABHD6, 2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Mitochondrion membrane; Single-pass type II membrane protein.
Protein: RS16_AGARV
Sequence: MAVKIRLRRMGQKKAPFYRIVVADSRSPRDGRCIEEIGTYDPTKDPSEYHVNEELAKKWLSNGAQPTETVARIFKSAGIEK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RFAY_XANCP
Sequence: MHADTLDAMLHHELPHAAAGCQQAYGRIVTACQNTVTAIALAITRDVAASEDIAQEAFLRAWQRLAQLHQPASFLPWLRQITRNLARDWLRSHRHRPLSGEAADLAIAMAADPSPSPAEQALQVEEERAALEIMSALPNDSREILLLYYREGQRSQQVASLLGLSDAAVRKRLSRARATVRNELLQRFDTFARGSAPGVAFATTVTAATMLAAPGTASAAIALGGIGSLGGVGKLGASGLSGSALTSGSAAGALSVLLGMPMAIALLAITGVTLTTYMSGAYLLRFATTAREAAAIRGFTRLSTLTAALTCGAPLLLRAFGAPKWLALCVLAVGMSVVCYHTLGTLPRIMQPMLERDARRRGTTRPPLLYRCMFSRSAIAVSLAAVIVPIAYRYGVLGLV
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is involved in lipopolysaccharide biosynthesis and pathogenicity.
What are the official names of this protein?
Probable RNA polymerase sigma factor RfaY.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
Protein: ISPF_SHESA
Sequence: MKIRIGHGFDVHKFGEARPLILCGVEVPYETGLVAHSDGDVVLHAISDAILGAMALGDIGKHFPDTDAAYKGADSRVLLRHCYALARAKGFELGNLDVTIIAQAPKMAPHIEDMRQVLAADLNADIADINVKATTTEKLGFTGRKEGIAVEAVVLLSRQ
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RS14_WOLTR
Sequence: MAKKSIVQRNLRRIKLCDQYGEKRERLKSIINNKNIPIGERFAAQNKLIKELPRDSSKIRIRNRCALTGRPRGVYRKFGLCRIVLRGLCSFGKIPGITKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: SKR1_CAEEL
Sequence: MADQKKVSEAAKEREIKISSSDNEIFLVPRNVIRLSNTINTLLMDLGLDDEEGTNAEPIPVQNVTASILKKVISWCNHHHSDPISTEDSDNREKRTDDIGSWDVEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKSPEEIRRTFNIKNDFTPEEEEQIRKENAWCED
What is the function of this protein?
Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846).  Regulates cell proliferation during embryonic and larval development (PubMed:11864567, PubMed:11864566).  Involved in synapse elimination in early synapse development (PubMed:17626846).  May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress (PubMed:18340346).  Plays a role in sex determination (PubMed:18718460).
What are the official names of this protein?
Skp1-related protein.
What is the protein family that this protein belongs to?
Belongs to the SKP1 family.
Protein: MTBP_XENTR
Sequence: MERFVLCIHWERRAESGAEQHRVPQGLAYAQDIYTQLKEYSTKYTSTFPACSLTGNPGTRKWFFALQSLYGSFQFCSSDWDDLCPAVTTEDNEEPVQTALDECLEALQFPDGEDDNSRDSISQTNLFEEAAELLHQLSDKLPAPGRALVDVLLFTPEAPKLKDCLSAIGAIKHLKEWHSAKITIVSKDCKGWQKIAKFLSANVVESACPKELIDSHELWRGNIEISERKFTSEVEFPEFCLRSVSDDKFPYFEHNGDDKNKAVLLPEVFHYYGTSLEYVQMVALSEIPSYFVSDSVFELSITRNALQGKSKLMLDQLCSLTDKVGAIFMLSCNVCSLPNPPALQRSSKKWREYMSRKPKDIKVPGVELKGEYCSYYFLIQGKGSGFCKATLLHSASQISGAASLVLLHQRLNNYQPGNMAEGTSEILDSVPHFRGEQIAVRERILARAQALAVNEYLKRHEALPHPSVSHVNNLRTLLAVTRERVIGDCESRLDGVSYKNLQNITVSTPTVSESEAMISNPADWPERNVLQNLENFEKVKQRLRASILSSSAEQLLGRKDGLKEGMTLLDAKELLKYFTPQGIAVGELQPLQVQRGDNAFLLTPKLTPKKLKGLPFEKAAECHYHGLEYCLDNRKALDRDVAFSELQSRLIRYETQTTCTRECCPVPFALSPLPSPAVLSEPGSVPDGESIQTELRGEPLLLKRRSRDLDGLYASKRLAKSGSSDSLVSLASEGSGHQPPTRATRLRPERAASSTSAVQPPSARVQMAPSVPAQSKQSTHPDLEQKESRSQKHNRMLKEVVSKTLQKYGIGVEHPCYAACNQRLFDISKFFLKDLKTSRGLLDEMKKAASNNAKQVIQWELDKLKKK
What is the function of this protein?
May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells.  Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability.  This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).
What are the official names of this protein?
Mdm2-binding protein.
What is the protein family that this protein belongs to?
Belongs to the MTBP family.
Protein: PLPP6_DANRE
Sequence: MPSPKARSGSGRSGSVPCPGGNGRYEFISLNRTPPSPVPPQLLQRQGSDPTTARLRASESPVRRRGSGSSNSSTGGGGQQLPEEDCMRLNPSFFGIALSSLLAIDLWLSKRLGVCACEDSSWGSVRPLMKLIEVSGHGIPWLAGAAYCLYKSDSPAGQEVMLNLLMALVLDVVLVGVLKAVVRRRRPAHNRMDMFATFSVDSYSFPSGHATRAAMCARFLLNHLVLAAPLRVLVLLWATIVGFSRVLLGRHNVTDVAFGFFMGYWQYNLVEMLWLSPVMLQSAIGQLH
What is the function of this protein?
Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates.  May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway.  May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins.  Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols.  May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate.
What are the official names of this protein?
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6, Phosphatidic acid phosphatase type 2 domain-containing protein 2, Phospholipid phosphatase 6.
What is the protein family that this protein belongs to?
Belongs to the PA-phosphatase related phosphoesterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. Nucleus inner membrane.
Protein: DADA_BRUA4
Sequence: MQITILGSGVIGVTTAYYLAKLGHEVTVVDREEGPALETSFANAGQVSPGYASPWAAPGIPFKAAKWLFQKHAPLVLRPTCDPVQYSWLLQMLANCTDSRYKVNKTRMVRVAEYARDCLVDLRKETGIEYDQRMQGTLQLFREQYQLDGIGKDIEVLRQDGVPFEVLDREGCAKVEPALARVKDKFVGGLRLPHDETGDCFKFTNALAKIAEGLGVKFRFGVNIKSLLMSGGKVSGVETSEGVLTADRYVVALGSYTPALVKSLGLNAPIYPVKGYSITAPIVDEDRAPVSTVLDESYKIAITRLGDRIRVGGMAEVSGFTTDLPAARRATLDLSVTDLFPGGDLKAATFWSGLRPMTPDSTPIIGATRYDNVFINAGHGTLGWTMSCGSGKLLADLISGNKPDIRADDLGISRYE
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: HSF_ENTBH
Sequence: MAKRKEVTEISEMDIKKSGFVNRLYRETCDISNKYIKFDDDGDKLIIPNKIDFIKKALNKISSTKDYSSFVRQLNNYGFTKIKLDNGDSNCDIYYHQNFHRDHPDLISLITRDKSKNGDYKDNMTTFINSLQYLASCNYKQQKEINDLKDRIKTLETKYATLYEIISNAFRQGIEQYQKHNTMYFNNNSLLKNMFTYNQELDDLKDNTNVYNNAKLINQLKLDAKNSNQDDNIKKTKNAFDEFYF
What is the function of this protein?
DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription.
What are the official names of this protein?
Heat shock transcription factor, HSTF, Heat shock factor protein, HSF.
What is the protein family that this protein belongs to?
Belongs to the HSF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYREL_HALVD
Sequence: MKNVDDLIASAAELADRGLSKGEIADELNVSRETASWLVERSGAATEPEPRAEPEGPDDIHVDWNAIGSGGKRLTYVGRALADLLMETNGEADVTVGIEKAGVPLATSVSRELETTLGAYSPAKHQWDEGDLEDLGGGFSRNFSPVEGRDCFIVDDTVTSGTTLRETIDAIRSEGGEPLACVVIVDKQGVEEIDGVPVHSLINVVRVGEQ
What is the function of this protein?
May have some orotate phosphoribosyltransferase activity, but not enough to ensure growth in the absence of the physiological OPRT.
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: TXPR2_ALOMR
Sequence: AKACTPLLHDCSHDRHSCCRGDMFKYVCDCFYPEGEDKTEVCSCQQPKSHKIAEKIIDKAKTTL
What is the function of this protein?
Enhances the high-affinity desensitization of human P2RX3 purinoceptors (PubMed:22842000).  At 50 nM, the toxin decreases the IC(50) for ambient ATP from 2. 67 nM to 0. 77 nM in human P2RX3 (PubMed:22842000).
What are the official names of this protein?
Purotoxin-2, PT2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 05 (U4-Lctx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RRAAH_BURTA
Sequence: MMFATTDLCDANEERLAAGTLRVIEPVFRSFGGVRRFAGPAATLKLFEDNTLVRAALEQDGAGRVLVVDGGGSLRCALVGGNLGKLAEKNGWVGIVVNGCVRDSAELAECRAGVLALAAHPRKSDKRGAGVSDVPVDVRGTRIAPGDWIYADADGILVSDAALLA
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: OXD_RHOER
Sequence: MESAIGEHLQCPRTLTRRVPDTYTPPFPMWVGRADDALQQVVMGYLGVQFRDEDQRPAALQAMRDIVAGFDLPDGPAHHDLTHHIDNQGYENLIVVGYWKDVSSQHRWSTSTPIASWWESEDRLSDGLGFFREIVAPRAEQFETLYAFQEDLPGVGAVMDGISGEINEHGYWGSMRERFPISQTDWMQASGELRVIAGDPAVGGRVVVRGHDNIALIRSGQDWADAEADERSLYLDEILPTLQSGMDFLRDNGPAVGCYSNRFVRNIDIDGNFLDLSYNIGHWASLDQLERWSESHPTHLRIFTTFFRVAAGLSKLRLYHEVSVFDAADQLYEYINCHPGTGMLRDAVTIAEH
What is the function of this protein?
Catalyzes the dehydration of aldoximes to their corresponding nitrile (PubMed:16233624, PubMed:19740758).  Is active toward various arylalkyl- and alkyl-aldoximes, and to a lesser extent toward aryl-aldoximes (PubMed:16233624).
What are the official names of this protein?
Aliphatic aldoxime dehydratase, Aldoxime dehydratase, OxdRE.
What is the protein family that this protein belongs to?
Belongs to the heme-containing dehydratase family.
Protein: CH60_ECODH
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKLADLRGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKNDAADLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC175_HUMAN
Sequence: MALSPWTPGLGAGEKLVQAAAVSTGPSLELCTLPSTLGSSVAVEALEQLFVVEQSLQSDYFKCNEEAKIFLKDIAVAVKKLEEMRKATIDLLEIESMELNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTKYNEALGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKINLKREDIALQKKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVKRMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSELKKDLAILEAKLCFFTDNKEKLDDISNDEKNEFLNKIKQLVETLHAARMEYKDLREKMKTLARQYKIVLSEEEKAFLQKQKIHDENQKQLTFISQKEYFLSQKRVDIKNMEEGLITLQELQQATKTVYQQQIKILSANLERESQRCVITQWKMACLRKKHARWTAKIKAEIQAITEKIQNAEVRRIELLNETSFRQQEISGFVAQIEKLTTELKEEEKAFVNKEKMLMKELSKYEEIFVKETQINKEKEEELVEYLPQLQVAEQEYKEKRRKLEELSNIITAQRQEEDLLNNHIFLFTRDFSRYISNMEDVKQELQQLRDQESKKNKDHFETLKNLENGFYINDQKADLLLLENKKLKEYILYLKNNIEKYREGQEALMHTSSDLSRQLIAQEAQYKDLWAEFQTTVKILVDNGEETLQDINNLTDKLRERDEKMQHVSTWLRGSLEGLRLLVEQESPMDLLKKKKHIRTRVHFPVVKCTEKNTLTK
What are the official names of this protein?
Coiled-coil domain-containing protein 175.
Protein: PGH1_BOVIN
Sequence: MSRQGISLRFPLLLLLLSPSPVLPADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYYGPNCTIPEIWTWLRTTLRPSPSFVHFLLTHGRWLWDFVNATFIRDKLMRLVLTVRSNLIPSPPTYNVAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMVYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRELRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGDVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPHREDRPGVERPPTEL
What is the function of this protein?
Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response.  The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes.  This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins.  The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons.  Involved in the constitutive production of prostanoids in particular in the stomach and platelets.  In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection.  In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.  Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products.
What are the official names of this protein?
Prostaglandin G/H synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1.
What is the protein family that this protein belongs to?
Belongs to the prostaglandin G/H synthase family.
What are the subcellular locations of this protein?
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: FIS_EDWI9
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: VSPH7_TRIST
Sequence: MVLIRVLANLLILQLSYAQKSSELIIGGDECNINEHRFLVALYTFRSRRFHCGGTLINQEWVLSAARCDRKNIRIKLGMHSTNVTNEDVQTRVPKEKFFCLSSKTYTKWNKDIMLIRLKRPVNNSTHIAPVSLPSNPPSLGLVCRVMGWGTISATKETHPDVPHCANINILDYSVCRAAYARLPATSRTLCAGILEGGKDTCHGDSGGPLICNGQVQGIVSWGGHPCGQPRKPGLYTKVFDHLDWIKSIIAGNKDATCPP
What is the function of this protein?
Snake venom serine protease homolog that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine protease homolog KN7, Serine proteinase-like protein KN7.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YBEY_LIMRD
Sequence: MDLEIFDQTTAQLPNEQLEMVRDLLQYAAKELSLSENTEMSLTFVNNPEIKKLNAQYRNVDRATDVLSFAAEEAGDETPIIMDPEMAAEIPVNLGDLFISIDKVAEQAKFLGHSVDRELGFLAVHGFLHLNGYDHEEPADEEKMFKLQREILDGYGLTR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBM6_HUMAN
Sequence: MWGDSRPANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGPHGDYRGGEGPGHDFRGGDFSSSDFQSRDSSQLDFRGRDIHSGDFRDREGPPMDYRGGDGTSMDYRGREAPHMNYRDRDAHAVDFRGRDAPPSDFRGRGTYDLDFRGRDGSHADFRGRDLSDLDFRAREQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTTDLDFRDRDTPHSDFRGRHRSRTDQDFRGREMGSCMEFKDREMPPVDPNILDYIQPSTQDREHSGMNVNRREESTHDHTIERPAFGIQKGEFEHSETREGETQGVAFEHESPADFQNSQSPVQDQDKSQLSGREEQSSDAGLFKEEGGLDFLGRQDTDYRSMEYRDVDHRLPGSQMFGYGQSKSFPEGKTARDAQRDLQDQDYRTGPSEEKPSRLIRLSGVPEDATKEEILNAFRTPDGMPVKNLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQGTLMIQDKEVTLEYVSSLDFWYCKRCKANIGGHRSSCSFCKNPREVTEAKQELITYPQPQKTSIPAPLEKQPNQPLRPADKEPEPRKREEGQESRLGHQKREAERYLPPSRREGPTFRRDRERESWSGETRQDGESKTIMLKRIYRSTPPEVIVEVLEPYVRLTTANVRIIKNRTGPMGHTYGFIDLDSHAEALRVVKILQNLDPPFSIDGKMVAVNLATGKRRNDSGDHSDHMHYYQGKKYFRDRRGGGRNSDWSSDTNRQGQQSSSDCYIYDSATGYYYDPLAGTYYDPNTQQEVYVPQDPGLPEEEEIKEKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEESPPPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTPPPQPRTAQPQKREEQTKKENEEDKLTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQNLEIHRKIKQSEQELAYLERREREGKFKGRGNDRREKLQSFDSPERKRIKYSRETDSDRKLVDKEDIDTSSKGGCVQQATGWRKGTGLGYGHPGLASSEEAEGRMRGPSVGASGRTSKRQSNETYRDAVRRVMFARYKELD
What is the function of this protein?
Specifically binds poly(G) RNA homopolymers in vitro.
What are the official names of this protein?
RNA-binding protein 6, Lung cancer antigen NY-LU-12, Protein G16, RNA-binding motif protein 6, RNA-binding protein DEF-3.
What are the subcellular locations of this protein?
Nucleus.