PharMolix/UniProtQA huggingface dataset:
Protein: HBB_TURME
Sequence: VQWTAEEKQLITGLWGKVNVAECGGEALARLLIVYPWTQRFFASFGNLSSPTAVLGNPKVQAHGKKVLTSFGEAVKNLDSIKGTFAQLSELHCDKLHVDPENFRLLGDILVVVLAAHFGKDFTPDCQAAWQKLVRVVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TAL_SHELP
Sequence: MANTLEQFKSITTIVADTGDIEAIKRYQPQDATTNPSLILKAAQIPEYKHLIANAIEWAKAQSDDLAQQVEDAGDKLAVNIGLEILKIVPGRISTEVDARLSFDKAGSIEKAHKLIKLYEEAGIDKSRILIKLASTWEGICAAKELEKEGINCNLTLLFCFAQARACAEAGVYLISPFVGRILDWYKKDTGLEYSAAEDPGVVSVTNIYNYYKRHGYKTVVMGASFRNTGEIIELAGCDRLTIGPALLEEMANSDTPVVQKLQAANEVVAPGAALSEAEFRWEFNQDAMAVEKLAEGIRNFAIDQGKLETMLKAELEA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_AGRRK
Sequence: MKANIHPDYHTIKVVMTDGTEYETRSTWGSEGATMNLEIDSKSHPAWTGGNQQLMDRGGRVSKFNKRFGSLGV
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: METN_XANOR
Sequence: MIEFQRLHKSYSVDGRQIVALHPLDLRIGPGEVFGIIGHSGAGKSTLIRLINRLEEPSGGRLLIGDEDVTALDSQGLRALRRRIGMIFQHFNLLSARTVAGNVAFPLELVGTPRAEIDARVAELLARVGLQEQANQYPAQLSGGQKQRVGIARALATGPQILLCDEATSALDPQTTASVLQLLAQINRELGLTIVLITHEMDVIRRVCDRVAVLDAGKLVETGPVTEVFLHPKHVTTRRFVSEAEHLDEAELHRDFAAVGGRIVRLTFLGNGTYEPVLGRIARDTGVDYNILSGRVDRIKDTPYGQLIVALTGGDQTAARAGFVAAGVQVEDLRV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y1804_BRUMB
Sequence: MSDDITSEAQTIAVGQLRAFIERIERLEEEKKTIGDDIKEVYAELKGSGFDSKVVRTIIRLRKKEDHERQEEEAMLQLYMDALGMS
What are the official names of this protein?
UPF0335 protein BMEA_A1804.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: RS3A1_YEAS7
Sequence: MAVGKNKRLSKGKKGQKKRVVDPFTRKEWFDIKAPSTFENRNVGKTLVNKSTGLKSASDALKGRVVEVCLADLQGSEDHSFRKIKLRVDEVQGKNLLTNFHGMDFTTDKLRSMVRKWQTLIEANVTVKTSDDYVLRIFAIAFTRKQANQVKRHSYAQSSHIRAIRKVISEILTKEVQGSTLAQLTSKLIPEVINKEIENATKDIFPLQNIHVRKVKLLKQPKFDVGALMALHGEGSGEEKGKKVTGFKDEVLETV
What are the official names of this protein?
40S ribosomal protein S1-A.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: APT_PROM9
Sequence: MEKLEKLISTYENYPKAGVSFKDVIEIVQHPSIFRQLILEMAKSKIIKEAEALISIDARGFIFGSAISIQAAKPMIVARKPGKLPGELVTKKYSLEYGENSLSIQKKALKKYNSFAIIDDLLATGGTVNCVSELINNNNKKVVGLLVVAELSKFDGRSRFNFPVESSILF
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDK_SALPB
Sequence: MSQTITLIKDKILSDNYFTLRNITYDLTRRNGEVIRHKREVYDRGNGATILLYNSTKKTVLLVRQFRVATWVNGNQDGMLIETCAGLLDNDEPEVCIRKEAIEETGYDVGEVRKIFELYMSPGGVTELIHFFIAEYHDSERASIGGGVEDEEIEVLELPFSRALEMVRSGEIRDGKTVLLLNYLQTSHLMD
What is the function of this protein?
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
What are the official names of this protein?
GDP-mannose pyrophosphatase, GDP-mannose hydrolase, GDPMK.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudK subfamily.
Protein: RIMO_SHIF8
Sequence: MSKVTPQPKIGFVSLGCPKNLVDSERILTELRTEGYDVVPSYDDADMVIVNTCGFIDSAVQESLEAIGEALNENGKVIVTGCLGAKEDQIREVHPKVLEITGPHSYEQVLEHVHHYVPKPKHNPFLSLVPEQGVKLTPRHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPIGEVLSEAKRLVDAGVKEILVISQDTSAYGVDVKHRTGFHNGEPVKTSMVSLCEQLSKLGIWTRLHYVYPYPHVDDVIPLMAEGKILPYLDIPLQHASPRILKLMKRPGSVDRQLARIKQWREICPELTLRSTFIVGFPSETEEDFQMLLDFLKEARLDRVGCFKYSPVEGADANALPDQVPEEVKEERWNRFMQLQQQISAERLQEKVGREILVIIDEVDEEGAIGRSMADAPEIDGAVYLNGETNVKPGDILRVKVEHADEYDLWGSRV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_SULDN
Sequence: MREAIHLGCEKCTRRNYHTTKNKKTHTEKFSVKKYCKFCREHTLHKEMKL
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PYRE_STRM5
Sequence: MSDHRHRFLQLALTADALRFGQFTLKSGRLSPYFFNAGRFDSGSLLSQLGACYSDAIDATGIKYDVVFGPAYKGIPLATAMACELAQRGRELPLSFNRKEAKAHGEGGQLIGADMNGKRVLIVDDVITAGTAIREALGIIRDAGGIPAGIVVALDRQEIASDTDHRSAAQAVAEEAGIPVIAVATLADLLDFASGNPELVGYRQPLEAYRAQYGVRSIR
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: PK81G_PSEFD
Sequence: MLDTLQKHGHCEVDTARIYGFGSTEEHLAQLKWQERGIAVGTKLTAKKIGPKEYSHKKESLKPGLSESLKALGSERVDTFYLHTPDHNTPYAETLEAVNELYKAGYFKKFGICNYAAWEVAQICELCNANGWKKPDIYQGAYSALQRNIETELFPCLRYYGISFYSFSPLAGGMLTDRYGRETSEYEGGNRFDPNNARGFYRKLYWNEPTFAALDIIRPLAQKHGMTTTKAALRWISHHSAMKGDKGDAVVIGSSSAEQLESNLSNLEKGPLPEDLVQAFEEAWSVVKVNTAPYFA
What is the function of this protein?
Aldo-keto reductase; part of the gene cluster that mediates the biosynthesis of an emodin derivative that may be involved in black Sigatoka disease of banana (PubMed:27388157, PubMed:30735556).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase PKS8-1 (Probable).  The atrochrysone carboxyl ACP thioesterase MYCFIDRAFT_190111 then breaks the thioester bond and releases the atrochrysone carboxylic acid from PKS8-1 (Probable).  The decarboxylase MYCFIDRAFT_34057 then catalyzes the concerted decarboxylation-elimination required to convert atochrysone carboxylic acid into emodin anthrone, which is further oxidized to emodin by the anthrone oxygenase MYCFIDRAFT_34418 (Probable).  The functions of the other tailoring enzymes as well as the final product of the cluster have still to be identified (Probable).
What are the official names of this protein?
Aldo-keto reductase MYCFIDRAFT_156381, PKS8-1 gene cluster protein MYCFIDRAFT_156381.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Protein: TP4A1_RAT
Sequence: MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
What is the function of this protein?
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis.  May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
What are the official names of this protein?
Protein tyrosine phosphatase type IVA 1, Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=And mitotic spindle.
Protein: TOP3A_ORYSJ
Sequence: MHHGGGGGAIRVLNVAEKPSVAKSVAEILSRPSGGMRSREGRSRYNRVFEFDYSIGGRACHMLVTSVTGHLMELEFDDRFRRWHSCDPADLFHAPVRKSVPQDKQDIKRTLEEEARKCQWLVLWLDCDREGENIAYEVIDICAGANSRLNIWRARFSALIDREIHEAVQHLDRPNKLFADAVDARQEIDLRIGASFTRFQTMLLKDAFVLDDTGDDRNIILSYGPCQFPTLGFIVERFWEIQAHEPEEFWTINCSHTSDEGTASFGWIRGHLFDYSSAVVIYEMCVEEPMATVQNVRNQEKLKYPPYPLSTIELQKRASRYFRMSSEHTMKVAEELYQAGFISYPRTETDNFSPNTDLHSIVHEQVAHPNWGTYAQRLLDPEARLWRNPSNGGHDDKAHPPIHPTKFSAGETNWTDNHKKLYELVVRHFLACCSQPAVGAETTVEIDIAGEQFNASGRVVLAKNYLDVYRFDSWGGTLLPTYIIGQQFVPTTLTLDSGMTRPPPLLAEADLLGCMDKAGIGTDATMHDHIKKLLDRCYATKDANTRFSPTNLGEALVMGYDEMGYELWKPYLRSMMEADMKSVSIGTKSKSEVLENCLQQMKACFLDARANKVKLFDAMGTFFARSSRPVNETQNSIETVRPCAACNESEMFLKQRPTGEFMVGCRGFPQCRNVVWLPRSLSGAAVTDQVCPTCAPGPVYKIQFKFRRRDIPPNFDVDHLGCIGGCDDILKELMELSRFGSHSQTATPARNQSQTASGVRQGSSRQDLHTSFHPAVQFTNGQTPVVNPQGFRSTHTQSSGNASGQVQCTSCREPCVLRTANTEANRGRKFYKCQNLACGFFAWEDDVENSAPRGRGGRGRGGRSSSRQSSASASAGRRGGTQGRGRRGRGRNADGMMFVAATGEPVYGSCFICGDPTHFANVCPNLGR
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.  Essential component of the RMI complex, a complex that plays an important role in the resolution step of homologous recombination, in a process called Holliday Junction dissolution, to limit DNA crossover formation in cells (By similarity).
What are the official names of this protein?
DNA topoisomerase 3-alpha.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: COAA_ACTP2
Sequence: MSLQKSNKITPFLTFDRQKWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLARLINYYIEENLKRQTVLHRFLDVASPKVPYIISIAGSVSVGKSTSARILQALLSQWPSERKVDLITTDGFLYPLTTLQEKDLLKRKGFPESYDIHRLIQFVSDIKSGKRHIQAPIYSHLTYDIIPDQYNVVDQPDIVILEGLNVLQSGMNYPSSPHNVFVSDFVDFSIYVDADEDLLKEWYVARFLKFRRSAFSDPNAYFHHYSKLSEQEAIRTASSIWDEINGLNLKQNILPSRERANLILIKGEDHAIQTVKLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTBB_BPSPB
Sequence: MSKLRVMSLFSGIGAFEAALRNIGVDYELIGFSEIDKYAIKSYCAIHNVSETLNVGDISKAKKDNIPYFDLLTSGFPCPTFSVAGGRDGMEYKCSNCSHEHLITYEDYKKGVKCPKCEAVSKAKDERGTLFFETALLAEEKKPKFVILENVKGLINSGNGQVLRIISETMNNIGYRIDLELLNSKFFNVPQNRERVYIIGIREDLVENEQWVVGQKRNDVLSKGKKRLQEINIKSFNFKWPLQDTVTKRLREILEDFVDEKYYLNEEKTKKLVEQLGTAPLQKQEVREPLMVGHVDLKGHDAIKRVYSPEGLSPTLTTMGGGHREPKIAEKQKEVRAVLTPEREEKRQNGRRFKENGEPAFTVNTIDRHGVAIGEYPKYKIRKLSPLECWRLQAFDDEDFEKAFAAGISNSQLYKQAGNSITVSVLESIFQELIHTYVNKESE
What is the function of this protein?
A methyltransferase that methylates C-1 within the sequences 5'-GGCC-3' and 5'-GCNGC-3' (PubMed:12654995).  Modification confers resistance against restriction enzymes that recognize these sequences (Probable).
What are the official names of this protein?
Orphan methyltransferase M.SPBetaI, M.SPBetaI, Cytosine-specific methyltransferase SPBetaI, Modification methylase SPBetaI.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Protein: NUOB_MYCMM
Sequence: MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMATAGPRFDIARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQEMPLGVNRERAIAEAEEAAMLARPTIEMRGLLR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYH_CHLTR
Sequence: MSNALPKGVFDIFPYVTSPKNLWRNSSLWKRVEHAAHRICNLYGFDEIRTPVFEKTETFLRVGEYSDIVKKEVYTFLDKKRRSLTLRPEGTAAVVRALLDHSADMRKDNKFYYILPMFRYERQQSGRYRQHHQFGLEAIGVRHPLRDAEVLSLLWDFYAAVGLQHMQIHVNFLGGQKTRARYDEALREFFRKDLDRLSPLSQERYHANLLRILDSKEPEDQEFIEKAPSILDYIDDRDLSYFDAVLAQLKALGISFAINPRLVRGLDYYTDLVFEAVTVVGEHSYALGGGGRYDELVAQSGGPSMPAFGFGVGLERVIQTLLEQGNSLSTSTRRLRLIPMDEQADAFCFSWANRLRNLGIATEVDWSHKKPKLSLKDAADQQVSFVCLLGEQELATKQFIVKDMSLHQSFSGAQQDVEQRLVYEVQNA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GST_ASADI
Sequence: PSYKLHYFDLRAAGE
What is the function of this protein?
Has a strong specific activity toward 1-chloro-2,4-dinitrobenzene and ethacrynic acid.
What are the official names of this protein?
Glutathione S-transferase, GST class-sigma, adGST.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Sigma family.
Protein: VTS1_DEBHA
Sequence: MDRPGFSSPPFNDKKIVLSPPPIESKQYSFLQQHNANSGPPVGFQERQQSVGYNLQQEFETLTADLDLDLRNNKDMQQNVDAPLPTTQSGNVGRGMMPSTSQYGFGELGTGGSLQNALLTDAALSPNLPTASSHSALGSLLNNNGNGSFLPPLASIPNRPQSVNDFSNFFNRQQQQQQTIDRQQQQQATNFYSDLIVFCNWIETLNPRDNITMIDYLCNNLPLDILLTFKSKLDSHLTHYHNQSATSQPLHQQQNQPVSFGVLSPYQQQQNDILAEMENLNLDNSLSSDAGASLNQKSAPALQQPKPKLNSVRNHGSHLYAEQQTQRPRSADPNIHKYSPNYNLPQQQFERTKSPTSHLYEKTNFLQLAAANSNPPSVSQQKGANNSDDSVDLSAHAALKLGALATINSRVALDSNRKSHVHSAHGHQQPHSHYFPQQGASQHGPFSPASAYEESINRSANSSSVPILVQHNKSPPGLTRSKKSTEGLGQGANASSGSPQTTSTTSMPADISNPDLLNNIPAWLKLLRLHKYTDCLKDIYWKDLIEYDDLSLEKRGVKALGARRKLLKAFDAVKESS
What is the function of this protein?
RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
What are the official names of this protein?
RNA-binding protein VTS1.
What is the protein family that this protein belongs to?
Belongs to the VTS1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, P-body.
Protein: MUKE_HAEIN
Sequence: MTDIQDVISPKLAVAIANPIFPAVDSLLRSGRHISTEHLDNHAFLMDFQNELDGFYRRYNVELIRAPEGFFYLRPKATTLIARSVLSELEMLVGKVLCYLYLSPERLAQQGIFSTQEVYDELLNLADEGKLLKAVNQRSSGSDLDKQKLAEKVRAAIGRLRRLGMIQTVGEQNSGKFTISESVFRFGAEVRSGDDPLESQARLIRDGEAATPDSLALEKQAQLMENDTKSADEIDEEFDGEQE
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Probably acts via its interaction with MukB and MukF.
What are the official names of this protein?
Chromosome partition protein MukE.
What is the protein family that this protein belongs to?
Belongs to the MukE family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: LPTD_BURCH
Sequence: MPPKPLFPNVFPGDGAPRKRRLALALLAVPGLVPAVSYAQLSGAAAQPQPLDSPWDLRLAPQLEDHPLKDGAKPAAFVIADHTSGTAEQDLAAKGSAELRRGDAVVKADAIHYDQDTDMADAYGQVKVINGGTSFAGPEAHLKIEANQGFMTAPKYHFNVTGGSGSAERVDMVDNERSVFVNGTYTACQCSTNPAWYIKGSRFDFDTGADEGTARNGVLFFQGVPIFASPWMTFPLSGERRSGLLPPTFSMNSSNGFELSLPYYFNIAPNRDLTLTPRIISRRGVMTEATFRYLSPSYSGTFTANYLPDDRLAHRNRYAIYWQHQQNFGGGFGGYVYYNKVSDNTYPEDLGSANQFINGTQTLYQQEAGLTYNNGPWSVLARYQHWQTLPPSIAPYSREPQLNVKYTKYNVGGFDFGAEADYSRFRITTADATEGDRIVFNPYISYGVYGPGYFVVPKVQYHFASYDLNYLSSTTPNSPKRFTESIPTVTFDTGLIFDRSVRLFGQDFIQTLEPRLYYVYTPYRDQSNAPLFDTAESDFGLAEIYQPNTFVGNDRIADANRITAGLTSRFIDPRTGDERARFVIAQQYYFADQRVTLNPGQAAVLARHSDLIVGAALKLGSGFMSETAFQYNQNNNQLVKSSVGFGYSPGERRVINVGYRYTRANTTLDNQPINQFLVSAQWPLTRRLYAIGRFNYDLAGDRVVDGLVGLQYDADCWALGVGVQRAANGINSSGQQNSSTRFMMQLTLKGLSTVDNGLVSAFRAGVPGYTPLPPPPPPMSRFSNYE
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: ASSY_SALAI
Sequence: MTERVVLAYSGGLDTSVAIPYLAEQTGAEVIAVAVDVGQGGEDLDAIRQRALDCGAVESEVVDARDEFAAEYCLPAVRANSLYMDRYPLVSALSRPLIVKHLVAAARTHGGTIVSHGCTGKGNDQVRFEAGLGALAPDLRIVAPARDFAWTRDKAIAFAEEKGLPIDVTAKSPYSIDQNLWGRAVETGFLEDIWNPPIEDLYAYTADPAEPRDADEVVITFDAGNPVAIDGETVTPYQAIVELNRRAGAQGVGRLDMVEDRLVGIKSREVYEAPGAIALIAAHQELEAVTVERDLARFKRGVDQRWGELVYDGLWFSPLRAALDAFVNDAQQHVSGDVRLTLHGGRATVTGRRSEASLYDFGLATYDTGDTFDQSLAKGFVQLWGLPSKMSAARDARLGGAQS
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCD4_ASPOR
Sequence: MARVGRVGFLTLAVVFHLMYAYSIFDIYFVSPIVSGMRSFGVEREASAEAPAKRLVLFVADGLRADKAFQALPDPDAPSDLENDEPIYLAPFIRSRALSHGTFGISHTRVPTESRPGHVALIAGLYEDVSAVTTGWKLNPVDFDSVFNRSRHTWSWGSPDILPMFKEGAVPGRIDADTYGEEAEDFSADATKLDIWVFDKVKELFASAKKDPELDAKLREDKLVFFLHLLGLDTTGHAYRPYSKEYLRNIKLVDKGVQEITQLVEDFYGDGKTSFVFTADHGMSDWGSHGDGHPDNTRTPLVVWGSGVASPRYTHEGTITGHEDGVSADWGLDSVQRNDVAQADVAALMAYLVGLDFPTNSVGQLPLGYLDTSPKDKALAALANAQGVLEMYRVKEEQKRDALLRYTPFEPLADNGETSVEARLERIKTLISNKSYDASIQLSSELLLTALEGLRYLQTYDWLFLRTIVSLGYLGWIAYALTTVIDLHVLHGKSESNRTTFSIMFFSSILVALFSVLLYQGSSWRYYLYALFPIFFWEEVFARRKALLAGREILLGHVHSVSGYFAFAIQLLLYVGVLEALVQSYFHRDIFTVCFILGGFWPITYGTKFLGQHKLLSASWALGCFLMSIFTLLPANKVEDMMMISCGSLLMFLTGLLYLIFERSILGQKRSSDPNSVVSSCGSRTIMGAQVGMILLALIVTRSSVASLQAKQGLPLGNQVLGWAILVSSLLLPFLHRLYPNSHYLHRLMVIFLTFSPIFIILTISYEGLFYFVFCMTLLAWVRLEQAIYIHTTAPTREQDHSVANGSLPAKKPSPGNTVVVEGQPYRYRTLSVSDARVALFFFFLLQSGFFSTGNIASVSSFSLDSVYRLIPIFNPFAQGALLILKLLIPFAIISANLGILNHRLEVAPSALFMVVMSISDVMTLNFFYMVRDEGSWLEIGTTISHFCIASFLCTFVAVLEFLSELFISGVDFGHPATTVGSAVAKAVNGSVACGHSPDSDISGEDSTSVGITAKADPDARS
What is the function of this protein?
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).
What are the official names of this protein?
GPI ethanolamine phosphate transferase 1.
What is the protein family that this protein belongs to?
Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VPU_HV1S1
Sequence: MQPLQILAIVALVVAAIIAIVVWTIVYIEYRKILRQRKIDRLIDRITERAEDSGNESEGDQEELSALVERGHLAPWDVDDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: DAPA_SHEDO
Sequence: MLKGSIVALITPMNRDGSVDNASLERLVEFHINQGTDAIVAVGTTGESSTLAQSEHIAVVEQVVSFAAGRIAVIAGNGANATAHGVELTQKLAKTGVDAMLGVTPYYNKPSPKGIIAHYTAIANSTDIAQILYNVPGRTCLDMQPEVIAELAKVSNIIGVKEATGDVSRVAKLRALCGDDFLLYSGDDASAKDFLLLGGDGVISVANNIVPKAFKVMCDAALSGNAELAKIHDDTLRGLYGSLFCEANPIPVKWASHQLGLITNAYIRLPLTELSEQFHGLLLETMKQAQLKV
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CEP20_CHICK
Sequence: MATIAELKAVLKDTLEKRGALRQIKARIRAEVFNALDDQSEPRPPLCHENLLINELIREYLEFNKYKYSASVLTAEAGQPEVPLDRQFLVKELNIVEDANGKSVPLLYGIISHFLHRGKEESTQSTLPKVSLLSYPRQNLAKPSTERNQKDRIPEPGRMAGTSIEEPLVLQSIKR
What is the function of this protein?
Involved in the biogenesis of cilia (By similarity).  Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity).
What are the official names of this protein?
Centrosomal protein 20, FGFR1OP N-terminal-like protein, LisH domain-containing protein FOPNL.
What is the protein family that this protein belongs to?
Belongs to the CEP43 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Protein: ZN415_HUMAN
Sequence: MPELYTEDFIQGCDVGELQEPGLPGVLSYVGAQERALDHRKPSTSSKKTKRVEIDQRCENRLECNGAISAHCNLRLPDSNDSPASASRVAGITDLSRNCVIKELAPQQEGNPGEVFHTVTLEQHEKHDIEEFCFREIKKKIHDFDCQWRDDERNCNKVTTAPKENLTCRRDQRDRRGIGNKSIKHQLGLSFLPHPHELQQFQAEGKIYECNHVEKSVNHGSSVSPPQIISSTIKTHVSNKYGTDFICSSLLTQEQKSCIREKPYRYIECDKALNHGSHMTVRQVSHSGEKGYKCDLCGKVFSQKSNLARHWRVHTGEKPYKCNECDRSFSRNSCLALHRRVHTGEKPYKCYECDKVFSRNSCLALHQKTHIGEKPYTCKECGKAFSVRSTLTNHQVIHSGKKPYKCNECGKVFSQTSSLATHQRIHTGEKPYKCNECGKVFSQTSSLARHWRIHTGEKPYKCNECGKVFSYNSHLASHRRVHTGEKPYKCNECGKAFSVHSNLTTHQVIHTGEKPYKCNQCGKGFSVHSSLTTHQVIHTGEKPYKCNECGKSFSVRPNLTRHQIIHTGKKPYKCSDCGKSFSVRPNLFRHQIIHTKEKPYKRN
What is the function of this protein?
Involved in transcriptional regulation.  Transcriptional activity differed among the various isoforms.  All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53.
What are the official names of this protein?
Zinc finger protein 415.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus.