PharMolix/UniProtQA huggingface dataset:
Protein: ADCY7_HUMAN
Sequence: MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
What is the function of this protein?
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable).  Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530).  Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity).  Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509).  Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production.  However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).
What are the official names of this protein?
Adenylate cyclase type 7, ATP pyrophosphate-lyase 7, Adenylate cyclase type VII, Adenylyl cyclase 7.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: XPO1_MOUSE
Sequence: MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFETLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHGQLLEKRLNLREALMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDIPPRRQLYLTVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTEIIMTKKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVNSHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTPLNPGNPVNNQMFIQDYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEERETALRQAQEEKHKLQMSVPGILNPHEIPEEMCD
What is the function of this protein?
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs.  In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form.  Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.  Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor.  The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  Involved in U3 snoRNA transport from Cajal bodies to nucleoli.  Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity).
What are the official names of this protein?
Exportin-1, Exp1, Chromosome region maintenance 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm (By similarity).
Protein: RL3_PSEU2
Sequence: MTIGVVGRKCGMTRIFTEEGVSIPVTVIEIEPNRVTQFKTEETDGYRAVQVTVGERRASRVTAAQAGHFAKANVAAGRTVMEFRLEEGDYQAGDQINAEIFAAGQLVDVTGQSKGKGFQGTIKRWNFRGQDNTHGNSVSHRVPGSIGQCQTPGRVFKGKKMSGHMGAERVTVQSLEVVRVDAERNLLLVKGAVPGATGGNLVVRPAAKARG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PLS3_PITAZ
Sequence: MAFLKKSLFLVLFLGLVSLSICEEEKRETEEEEYNQEDDDKSEEKRFLSLIPTAINAVSALAKHFG
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Phylloseptin-Az3, PLS-Az3, Phylloseptin-8, PS-8.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VF509_ASFK5
Sequence: MEAIISFAGIGINYKKLQSKLQHDVGRFLRALTITARALPGQPKHIAIRQETAFTLQGEYIYFPILLRKQFEMFNMVYTAHPVSLRALPCVETEFPLFNYQQEMVDKIHKKLLSPYGRFYLHLNTGLGKTRIAISIIQKLLYPTLVIVPTKAIQIQWIDELKLLLPHLRVAAYNNAACKKKDITSKEYDVIVGIINTLRKKPEPFFEPFGLVVLDEAHELHSPENYKIFWKIQLSRILGLSATPLDRPDGMDKIILHHLGQPQRTVSPTTTFSGYVREIEYQGHPDFVKPVCINEKVSAIATIDKLLQDPSRIQLVVNETKRLYSLHTAEPQKWGTNEPYGIIIFVEFRKLLEIFYQALSEEFKDVQIIVPEVALLCGGVSNTALSQAHSASIILLTYGYGRRGISFKHMTSIIMATPRRNNMEQILGRITRQGSDEKKVRIVVDIKDTLSPLSSQVYDRHRIYKKKGYPIFKCSASYQQPYSSNEVLIWDPYNESCLASTTTPPSPSK
What are the official names of this protein?
Putative ATP-dependent RNA helicase QP509L.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
Protein: PTPC1_BOVIN
Sequence: MQDPPRRLSAVPFLSSFFEGRRHSASDPILRLQQGRRSSAAKVLSSSSLQVMVAMSSVSCAERNPTCPERKRNSGRPTPKYTKVGERLRHVIPGHVACSMACGGKACKYENAARWSEQEQAVKGIYSSWVTDNILAMARPSTEVLEKFCIIEQFRSHGIKSIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLIPLRNIFSCCDPKAHAVTLAQYLIRQRHLLHGYEARLLKHIPKIIHLVCKLLLDLAENRPVVTEVADIPGLSAEIEKTVSEMITRQLDKELLRHDSDASDSFTPTAVVMDFENQDVVLSSEQELDPLWKRRNVECLQPLAHLKRQLSYSDSDLKRAESLLEQGRTPWTVPAQALLCHNPRQQKHISRCYSPQSPQLDLNKETLVRNTFSFWNHTKFGVPEGLKDDGSLIFHRTSIPKEVQRSRTFSSGISDSYNPGEPVTPNSANIPKGPNSSQQKVYHCECESHGGCGPSSVAEDGETCRRPVDCGSSPKAQFLGNETQNSKYLSEVAAHMPLQSELSVEARRILAAKALANLNEIAEKEEVKKKVEMWQKELNSRDGAWERICGEKDPFILCSLMWSWVEQLKEPVITKEDMDMLVDRCADASEALFLLEKGQQQTILCVLHCIVSLQTIPADVEEAVLARAIKAFTKVNFDSENGPIVYNTLKKIFKRTLEEKRKMTKDNPEPGI
What is the function of this protein?
May play roles in cilia formation and/or maintenance.
What are the official names of this protein?
Protein tyrosine phosphatase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class PTPDC1 subfamily.
Protein: CLPX_YERPP
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVSPHRDRSSLPTPHEIRHHLDDYVIGQEPAKKVLAVAVYNHYKRLRNGDTSNGIELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTIAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVIGQRINTGSGIGFGAVVKGQSEKATEGELLSQVEPEDLIKFGLIPEFIGRLPVVATLSELSEDALIQILKEPKNALTKQYQALFSLEGVELEFRDEALTAIAKKAMARKTGARGLRSIVEGALLDTMYDLPSMDSVEKVVVDESVIAGQSAPMLIYGQPEAQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RL16_METC4
Sequence: MLQPKKTKFRKQFKGRISGAAKGGFELNFGQFGLKCLEPERITARQIEAARRAITREMKRQGRVWIRVFPDLPVTAKPTEVRMGSGKGAPEYWAARVHPGRIMFEVDGVAEDIAREALRLGAAKLPVRTRVIQRIAD
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RBBP6_MOUSE
Sequence: MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADSDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPVMGTTKAIDDASASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKTLVGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPVPPPRPLMQRNLQPLMRSPISRQQDPLMIPVTSSSAHSAPSISSLTSNPSALAPSVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKLLPAAALTSEHSKGASSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINAARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANISTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPTKRNVPQGETEREYFNRYREVPPPYDIKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAVGAQPRPSANREDFSPERLLPLNIRNSPFTRGRREDYAAGQSHRNRNLGGNYPEKLSTRDSHNAKDNPKSKEKESENVPGDGKGNKHKKHRKRRKGEESESFLNPELLETSRKCRESSGIDETKTDTLFVLPSRDDATPVRDEPMDAESITFKSVSDKDKREKDKPKVKSDKTKRKSDGSATAKKDNVLKPSKGPQEKVDGDREKSPRSEPPLKKAKEEATKIDSVKPSSSSQKDEKVTGTPRKAHSKSAKEHQEAKPAKDEKVKKDCSKDIKSEKPASKDEKAKKPEKNKLLDSKGEKRKRKTEEKSVDKDFESSSMKISKVEGTEIVKPSPKRKMEGDVEKLERTPEKDKIASSTTPAKKIKLNRETGKKIGNAENASTTKEPSEKLESTSSKIKQEKVKGKAKRKVAGSEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKTTQPIQSVGKPSSIIKNVTTKPSATAKYTEKESEQPEKLQKLPKEASHELMQHELRSSKGSASSEKGRAKDREHSGSEKDNPDKRKSGAQPDKESTVDRLSEQGHFKTLSQSSKETRTSEKHESVRGSSNKDFTPGRDKKVDYDSRDYSSSKRRDERGELARRKDSPPRGKESLSGQKSKLREERDLPKKGAESKKSNSSPPRDKKPHDHKAPYETKRPCEETKPVDKNSGKEREKHAAEARNGKESSGGKLPCIPNPPDPPMEKELAAGQVEKSAVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEEAVASISKDLKEKTTEKAKESLTVATASQPGADRSQSQSSPSVSPSRSHSPSGSQTRSHSSSASSAGSQDSKKKKKKKEKKKHKKHKKHKKHKKHAGADGDVEKSQKHKHKKKKAKKNKDKEKEKDDQKVRSVTV
What is the function of this protein?
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity).  May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788).  Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner.  Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
What are the official names of this protein?
E3 ubiquitin-protein ligase RBBP6, Proliferation potential-related protein, Protein P2P-R, RING-type E3 ubiquitin transferase RBBP6, Retinoblastoma-binding protein 6, p53-associated cellular protein of testis.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome (By similarity).
Protein: DGTP_SALAR
Sequence: MASIDFRNKINWHRRYRSPQGVKTEHEILRIFESDRGRIINSPAIRRLQQKTQVFPLERNAAVRTRLTHSMEVQQVGRYIAKEILSRLKAQNLLEEYGLDALTGPFESIVEMACLMHDIGNPPFGHFGEAAINDWFRQRLYPEDAESQPLTHDRCVVSSLRLQEGEESLNDIRRKVRQDICYFEGNAQGIRLVHTLMRMNLTWAQVGGILKYTRPAWWRGPVPDSHRYLMKKPGYYLSEEKYIARLRKELQLAPYSRFPLTWIMEAADDISYCVADLEDAVEKRIFSVEQLYHHLYHAWGHHEKDSLFELVVGNAWEKSRANTLSRSTEEQFFMYLRVNTLNKLVPYAAQRFIDNLPQIFAGTFNQALLEDASGFSRLLELYKNVAVEHVFSHPDVEQLELQGYRVISGLLDIYQPLLSMSLNDFSELVEKERLKRFPIESRLFQKLSTRHRLAYVEVVSKLPMDSAEYPVLEYYYRCRLVQDYISGMTDLYAWDEYRRLMAVEQ
What is the function of this protein?
dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase, dGTP triphosphohydrolase, dGTPase.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 1 subfamily.
Protein: FL3H_MALDO
Sequence: MAPATTLTSIAHEKTLQQKFVRDEDERPKVAYNDFSNEIPIISLAGIDEVEGRRGEICKKIVAACEDWGIFQIVDHGVDAELISEMTGLAREFFALPSEEKLRFDMSGGKKGGFIVSSHLQGEAVQDWREIVTYFSYPIRHRDYSRWPDKPEAWREVTKKYSDELMGLACKLLGVLSEAMGLDTEALTKACVDMDQKVVVNFYPKCPQPDLTLGLKRHTDPGTITLLLQDQVGGLQATRDDGKTWITVQPVEGAFVVNLGDHGHLLSNGRFKNADHQAVVNSNSSRLSIATFQNPAQEAIVYPLSVREGEKPILEAPITYTEMYKKKMSKDLELARLKKLAKEQQSQDLEKAKVDTKPVDDIFA
What is the function of this protein?
Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R-dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.
What are the official names of this protein?
Naringenin,2-oxoglutarate 3-dioxygenase, FHT, Flavanone-3-hydroxylase, F3H.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: Y141_GEOSL
Sequence: MKILYFDCFAGIAGDMTVAALLDLGVPFEVVRDAVGCLRLPHSSYSLATERTSRKGITATRFVVHVEEHQPNRHYGDIAAMIEESPLADGIKEKAQRIFFRLAEAEAKVHGVELGRVHFHEVGAVDSIADIVGAAAAIDWLGIESIHGGALPLGSGFVETAHGRLPVPAPATAELLRGIPVHGEAGPGERVTPTGAAILAALAAGFGPIPPMTVTGVGCGAGTRDFADIPNILRVFQGEIDRGFERDDVVVIEAHIDDTSPEILGYVMERCLAAGALDAAFSPLQMKKNRPAVRLTVVVHPEQRDELAALILRETSAIGVRFHPAGRLKLRRLVEERDTTLGRVRVKVINGDGVARVAPEYDDCCRIAAERGMPLMEVYRIVERECGQ
What are the official names of this protein?
Putative nickel insertion protein.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: SYV_HELPJ
Sequence: MKQEPTTYQPEEIEKKIYEICSHRGYFEINGNEKIQEKGKRFCLMMPPPNVTGILHIGHALTLSLQDILVRYKRMDGYKTLYQPGLDHAGIATQNVVEKQLLSQGVKKEDLGREKFIQKVWEWKEKSGGAILEQMKRLGVSTAFSRTRFTMDKGLQRAVKLAFLKWYEKGLIVQDNYMVNWCTKDGALSDIEVEYEERKGALYYIRYYLENQKDYLVVATTRPETLFGDSAIMVNPNDERYKHLVGQQVILPLINRTIPIIADAHVEMGFGTGCVKVTPGHDFNDYEVGKRHHLETIKIFDEKGILNAHCGEFENLERLEARDKVVAALKENALLEKIEEHVHQVGHCYRCHNVVEPYVSKQWFVKPEIAQSSIEKIQQGLARFYPSNWINNYNAWMRELRPWCISRQLFWGHQIPVFTCENNHQFVSLDTPLSCPTCKSEKLEQDKDVLDTWFSSGLWAFSTLGWGQEKSDLFNESDLKDFYPNTTLITGFDILFFWVARMLFCSESLLGELPFKDIYLHALVRDEKGEKMSKSKGNVIDPLEMIEKYGADSLRFTLANLCATGRDIKLSTTHLENNKNFANKLFNAASYLKLKQESFKDKERLNEYQTALGRYAKSRLNLVTKEVRNALDNYRFNDATTLLYRFLWGEFCDWFIEFSKVENEAIDELGSVLKEALKLLHPFMPFISESLYHKLSNTELENAHSIMVMPYPKEIAQDEKLEHEFEVIKDCIVSLRRLKIMLETPPIVLKEASVGLREKIENTERLQNYAQKLAKLEKVSVITYKPLKSVSDVGEFCQTYADLENLDLSPLIARLKKQLEKLEKEKLKLNLHNENFVKNAPKSVLEKARESLKTLLEKEGKIQQELDLLEQP
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMTN_HIRME
Sequence: MGFEIPEPYVWDESFKVFYENLDEEHKGLFQAIFNLSKSPADNGALKHLSKVIDEHFSHEEDMMKKASYSDFDNHKKAHVDFQASLGGLSSPVANDKVHWAKDWLVNHIKGTDFLYKGKL
What is the function of this protein?
May play a role in the innate immune response of the leech nervous system to bacterial invasion.  The oxygen-binding site in each chain contains two iron atoms (By similarity).
What are the official names of this protein?
Neurohemerythrin.
What is the protein family that this protein belongs to?
Belongs to the hemerythrin family.
Protein: MYC2_CRODU
Sequence: MKILYLLFAFLFLAFLSEPGNAYKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSGK
What is the function of this protein?
Cationic peptide that possesses multiple functions.  It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel inhibitor.  It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism.  As a cell-penetrating peptide, crotamine has high specificity for actively proliferating cells, and interacts inside the cell with subcellular and subnuclear structures, like vesicular compartments, chromosomes and centrioles.  It penetrates into the cells as fast as five minutes after its addition to cell culture medium (PubMed:18662711).  In vivo, after intraperitoneal administration, it is found in cells of peritoneal fluid and bone marrow, demonstrating preferential nuclear and perinuclear localization.  To enter the cell, it interacts with the chains of heparan sulfate membrane proteoglycan (HSPG), and is endocytosed (in complex with HSPG) in vesicles which are transported into the cell with the help of clathrin.  Inside the cell, crotamine accumulates in lysosomal vesicles.  As soon as the peptide accumulates in endosomes/lysosomes vesicles, these compartments are disrupted and their contents released into the cytosol.  This loss of lysosomal content induces cell death at high concentrations, or promotes the distribution of crotamine in cytoplasmic compartments, which is a step before crotamine nuclear uptake (PubMed:15231729, PubMed:17491023).  As a potassium channel inhibitor, this toxin selectively inhibits Kv1. 1/KCNA1, Kv1. 2/KCNA2 and Kv1. 3/KCNA3 channels with an IC(50) of 369, 386 and 287 nM, respectively (PubMed:22498659).  The inhibition of Kv1. 3/KCNA channels induced by this toxin occurs rapidly and is voltage-independent.  The channel inhibition is reversible after washing, suggesting a pure and classical channel blockage effect, without effects in potassium channel kinetics (PubMed:22498659).  As an antimicrobial peptide, crotamine shows antibacterial activity against E. coli and B. subtilis, and antifungal activity against Candida spp. , Trichosporon spp.  and C. neoformans.  It kills bacteria through membrane permeabilization.
What are the official names of this protein?
Crotamine, Crt, Myotoxin.
What is the protein family that this protein belongs to?
Belongs to the crotamine-myotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYOE_FRATN
Sequence: MYFKRYLQLAKPGIIFGNLITLTGGFLLATHREIGFEYLPLFVYVMIGVALMIAAGCVFNNIYDKDIDSSMTRTQNRPLVTGDISVIQATIYGTILLILSCLVLYYLVNLLTLWIIIIGFIVYVGIYTVSKRLTIHATVLGGISGAIPPVAGYTAVVNILDYNALALFLILFFWQIPHSYAIAMLYIDDYKKVKLPMLPIVKGIAYTKKIMLFYLALFVVSCALPAVLGSADLFSFIVCMLVALFWMYKSIQSYRTDTDRVFAKTVFKFSIIVITAICLTMG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AMERL_MOUSE
Sequence: MGKRRCVPPLEPKLAAGCCGVKKPKLSGSGTHSHGNQSTTVPGSSSGPLQNHQHVDNSSGRENVSDLTLGPGNSPITRMNTASGALSPLPRPNGTANSTKNLVVTAEMCCYCFDVLYCHLYGFPQPRLPRFTNDPYPLFVTWKTGRDKRLRGCIGTFSAMNLHSGLREYTLTSALKDSRFPPLTREELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIEFINEKGIKRTATYLPEVAKEQDWDQIQTIDSLLRKGGFKAPITSEFRKSIKLTRYRSEKVTISYAEYIASRQHCFQNGTLHAPPLYNHYS
What are the official names of this protein?
AMMECR1-like protein.
Protein: GDF2_MOUSE
Sequence: MSPGAFRVALLPLFLLVCVTQQKPLQNWEQASPGENAHSSLGLSGAGEEGVFDLQMFLENMKVDFLRSLNLSGIPSQDKTRAEPPQYMIDLYNRYTTDKSSTPASNIVRSFSVEDAISTAATEDFPFQKHILIFNISIPRHEQITRAELRLYVSCQNDVDSTHGLEGSMVVYDVLEDSETWDQATGTKTFLVSQDIRDEGWETLEVSSAVKRWVRADSTTNKNKLEVTVQSHRESCDTLDISVPPGSKNLPFFVVFSNDRSNGTKETRLELKEMIGHEQETMLVKTAKNAYQVAGESQEEEGLDGYTAVGPLLARRKRSTGASSHCQKTSLRVNFEDIGWDSWIIAPKEYDAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISILYKDDMGVPTLKYHYEGMSVAECGCR
What is the function of this protein?
Potent circulating inhibitor of angiogenesis (By similarity).  Signals through the type I activin receptor ACVRL1 but not other Alks (PubMed:25751889).  Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG (PubMed:23300529).
What are the official names of this protein?
Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9, BMP-9.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: POTB3_HUMAN
Sequence: MVAEVCSMPAASAVKKPFDLRSKMGKWCHHRFPCCRGSGKSNMGTSGDHDDSFMKTLRSKMGKCCHHCFPCCRGSGTSNVGTSGDHDNSFMKTLRSKMGKWCCHCFPCCRGSGKSNVGTWGDYDDSAFMEPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRKSRKPENQQFPDTENEEYHSDEQNDTQKQLSEEQNTGISQDEILTNKQKQIEVAEKEMNSKLSLSHKKEEDLLRENSMLREEIAMLRLELDETKHQNQLRENKILEEIESVKEKLLKAIQLNEEALTKTSI
What are the official names of this protein?
POTE ankyrin domain family member B3.
What is the protein family that this protein belongs to?
Belongs to the POTE family.
Protein: DCLK2_RAT
Sequence: MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSISGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTVDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNVNPNWSVNIKGGTTRTLAVASAKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKYRYAQDDFVLDHSECRVLKSSYSRASAAKYSGSRSPGLSRRSKSPASVKRAGHSSAYSTAKSPVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAQGRSSSNVNGGPELDRCMSPEGVNGNRCSESFTLLEKYRIGKVIGDGNFAVVKECMDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETTTELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLASALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQVFCSKHCRDSSKSSREQTSAREAPPPPESPRPPGPPATSGCDPAGTWRRHRD
What is the function of this protein?
Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family.  May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase DCLK2, CaMK-like CREB regulatory kinase 2, CL2, CLICK-II, CLICK2, Doublecortin-like and CAM kinase-like 2, Doublecortin-like kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. When overexpressed in sympathetic neurons, localizes to cell body and to the terminal segments of axons and dendrites.