PharMolix/UniProtQA huggingface dataset:
Protein: DAPE_ACISJ
Sequence: MSPTLLLTEQLIARPSVTPDDAGCLDLLARRLAPLGFACERLDSGPENFRVSNLWSKRSAALSGQAQAATKTVVFAGHTDVVPTGPVEQWSSPPFTPTHRDGRLYGRGASDMKASIAAFVVAVEEFLAATPDPRLDIALLLTSDEEGPSVDGTKVVIEQLRARGERLDWCIVGEPTSVEQTGDMIKNGRRGTLSGRLTVRGVQGHIAYPQLARNPIHQAVPALTELAATVWDMGNAFFPPTSWQMSNIHGGTGATNVIPGQVVIDFNFRFSTESTAEGLQQRVHAVLDRHGLEYDLTWTLGGQPFLTTPGELVQAVQQAIRAETGLETELSTTGGTSDGRFIAQICPQVIELGPPNASIHKIDENVRLVDIEPLKNIYRRTLEHLNALAGA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: ALR_LEGPH
Sequence: MSRPTRLVIEPSALLHNLSQIKHLAPGKKVIAMVKANAYGCGVREVAPVLDGRIEAFGVACLEEALAIRALGVETPCILFQGVFSSDELSVAVENDFACVLHHAQQLEWLIKTPLPYPIKVWVKVNTGMHRLGFKIHELQKVMGALQTCTWVDKSIGLMTHLACADEPHRPENQQQISLFQEISIPGFRQRSIANSAAIISFPDSQADVVRPGIMLYGVSPFANQNAHDLGLIPVMRFMSAISAIHDNPSFAQVGYGGTWKSDKPSRIGVVAAGYGDGYPRHISEKTPVWVRGREVSIVGRVSMDMLTIDLTEHPDIEIGDEVELWGTHVLVERIAKSAGTVGYELLCQISERVRYK
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: PYRB_VARPS
Sequence: MLYKRNPQLNKNGELIHLLSIEGLPKDIVTHILDTAANFTSVSDREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSADVINLDIARSSATKGESLLDTIANLSAMAADLFVVRHSESGAPYLIAQHVAPHVHVVNAGDGRHAHPTQGLLDMYTIRHYKKDFANLTVAIVGDVLHSRVARSDIHALTTLGCAEVRVVGPKTLVPGDMAGMGVRVCHTLEEGIRDCDVIIMLRLQNERMSGALLPSSQEFFKTYGLTPEKLQLAKSDAIVMHPGPINRGVEIDSAVVDGKQSVILPQVTFGIAVRMAVMSIVAGNEA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TPS5_MATCR
Sequence: MASRENEIIRPKANFHPSVWGDQFLVYEEPEDQVEVEKMVEGLKEEVRKEIVVALDNPSKHTDLLVLINEVQRLGIAYYFEEEIERALKHIYDTYGDHWKGGSAPLWFRLLRKQGYYVSCDIFNQYKDNTGSFKESLTNDVHGMLELYEAAYMRVHDEVILDDAPVFTKTHLAKMLKDSLGYNPTLSKYIQDSLERPIRKRLPRVDALHYIPFYEQQVSHNKSLLKLSKLGFNLLQSMHKKELSELFKWWKHFDVEKNIPYMRNRFVENYFWALGAYFEPQYSRARIFLTKVFAFATMLDDTYDAYGVYKELEIFTQAVERWSLTCLDALPEYMKLIYKELLDLYEEMDDTMAKEGAPYHVKYAKEAMKEFIGSYMTEARWKHEGYVPTTEEHKAVAFISSGYKMLTIASFVGMGDIASEDSFKWALSNPPLIKASCSICRMMDDVVGHKEEKERVGGHVASSVDSYMKQHNVTEDHVYDLFNTLVEDAWKDLNRESLICKEIPMVLKMRLINLTCFIDTLYKYEDTFTNVGPELIDCIKSHLVHAMSV
What is the function of this protein?
Sesquiterpene synthase involved mainly in the biosynthesis of germacrene D.  Produces exclusively the (-)-enantiomer.
What are the official names of this protein?
(-)-germacrene D synthase, Terpene synthase 5.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
Protein: PLSX_COXBR
Sequence: MLKTIALDAMGGDNGPKVIVPAALSILKKHPKVKLILVGKEDQLALLIPEKNRKSFGQRLEIIHASEEVGMDEPPSQALRTKKNSSMRVAINLVKEGQAHACVSAGNTGALMATARYVLKTLPGIDRPAIIAAFPTKNEREVRVLDLGANVDSTPENLYQFAVMGSILSSAAHNIRNPRIGLLNVGEEEIKGNELVKKANELFETRKTINYIGYVEGNTIFNNIADVVVCDGFVGNAVLKASEGVAQLIKQHAKEAFSEAWWTKLALLPAIPILKRLIRRVDPERYNGATFLGLNGIVVKSHGSANIKAFVCAVEEAIFQVDKNIPQLIKEEVAHILKEFENK
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: 3S12A_DRYCN
Sequence: MKTLLLTLVVVTIVCLDLGYTMTCYNQQSSQPQTTTTCAESSCYKKTWRDHRGTIIERGCGCPTVKPGIQRVCCATDKCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin 2, SNTX-2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MVP_CFMVN
Sequence: MCEPPPGFITVQCYTSDDLLTGDSTIVKSIPVRSCFFRQGVEVVLFRCESNKHRWSKIRGPVSLTVHCDICEFRETVVIPSLPKGFKVSSDFSYSVTWNCCYSRGRTE
What is the function of this protein?
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding.  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier (Potential).  Also likely to act as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that performs sequence-specific inhibition of viral mRNAs expression.  Silencing activity has been seen in Nicotiana benthamiana and Nicotiana tabacum, two non-host plants.
What are the official names of this protein?
Movement protein P1, Cell-to-cell transport protein.
Protein: ORP3C_ARATH
Sequence: MGSPKKNENKGFFAAMTSGFSMFGTAVSRSVNGVQGNEGVEVINPEGGKEDAEEEAQKGRWKDEERDSYWKMMQKYIGSDITSMVTLPVVIFEPMTMLQKMAEIMEYSHLLDQADECEDPYLRLVYASSWAISVYYAFQRTWKPFNPILGETYEMVNHGGISFISEQVSHHPPMSAGHAENEHFIYDITSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKIHNLIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSAAEEPKIMMTGKWNEKMSYQPCDAEGEPLPGTELKEVWHLADVPKNDNFQYTHFAHKINSFDTAPAKLLASDSRIRPDRYSLEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITPTPWGDIEVYQYNGKYNEHRDTAESSSSASNETDLKSIEFNPWQYGNISTE
What is the function of this protein?
May be involved in the transport of sterols.
What are the official names of this protein?
Oxysterol-binding protein-related protein 3C, OSBP-related protein 3C.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: S35B4_MOUSE
Sequence: MRPAFAVGLVFAGCCSNVIFLELLARTHPGCGNIVTFAQFLFIAVEGFLFEANLGRKPPAIPIRYYAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLIANMILGIIILKKRYSMFKYTSIALVSAGIFICTFMSAKQVTVQTGLSDKDGFQAFAWWLLGIAALTFALLMSARMGIFQETLYRQFGKHSKEALFYNHALPLPGFIFLASDIYDHVVLFNKSELYQVPVIGVTMPVMWFYLLMNVVTQYVCIRGVFILTTECTSLTVTLVVTLRKFVSLIFSILYFQNQFTMWHWLGTSFVFIGTLMYTEVWKNLGTTKSELQKDDKKD
What is the function of this protein?
Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar.  May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics.
What are the official names of this protein?
Nucleotide sugar transporter SLC35B4, Solute carrier family 35 member B4, UDP-xylose and UDP-N-acetylglucosamine transporter.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: LIPA_STUS1
Sequence: MSSVETAGKRPAKVEAGVKLRGAEKVARIPVKIIPTDELPKKPDWIRVRIPVSPEVDQIKQTLRKHKLHSVCEEASCPNLGECFSSGTATFMIMGDICTRRCPFCDVGHGRPNALDPDEPKNLAQAIADMRLKYVVITSVDRDDLRDGGAQHFADCLREIRKLSPSIQLETLVPDYRGRMEIALDITATEPPDVFNHNLETVPRLYKSSRPGSDFEWSLDLLEKFKQRVPGVPTKSGLMLGLGETDEEVIEVMQRMREHDIDMLTLGQYLQPSRNHLPVQRFVHPDTFAWFAEEGMKMGFKNVASGPLVRSSYHADQQAHGAKHD
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Protein: EFTS_HELAH
Sequence: MSEISAQLVKKLRDLTDVGMMDCKKALVEVAGDLQKAIDFLREKGLSKAAKKADRIASEGVVALEVAPDFKSAVMVEINSETDFVAKNEGFKELVKKTLETIKVHNAHTREELLKSSLDNKPFEEYLHSQIAVIGENILVRKIANSKAPSSHIINGYAHSNARVGVLITMKYNNEKNAPKAVELARNIAMHAAAMKPQVLDCKDFSLDFVKKETLVLIAEIEKDNEEAKRLGKPLKNIPTFGSRIELSDEVLAHQKKVFEDELKEQGKPEKIWDKIVLGKMERFIADNTLIDQRLTLLGQFYVMDDKKTIAQVIADYSKELNDTLEITEYVRFELGEGIEKKAENFAEEVALQMK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_RENSM
Sequence: MANIKSQKKRILTNEKARLRNNAVKSELKTAVRAVNQAVEAGNKETAGEALVHASRKLDKAVSKGVIHSNQAANRKSAISKKVSALKG
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: DNAK_FINM2
Sequence: MSKVIGIDLGTTNSAVAVMEGGESVIVPNSEGNRTTPSIVAFTKDGERLVGETAKRQAITNPDRTITSIKREMGTEYKVNIDGKDYTPEEISAMILQKLKADTESYLGEEVTEAVITVPAYFTDSQRQATKNAGKIAGLNVKRIINEPTAAALAYGIDKETDQHKVMVYDLGGGTFDVSILEVGDGVFEVLATRGNNRLGGDDFDEKLLNYLADEFMKQNGVDLRKDPTSKQRLKDAAENAKKELSTRVSTNVNLPFISAVNGTPVHLNMDITRSKFDELTSDLVEESLKPVRQALEDAGLSHNDIEKVLLVGGSTRIPAVQEAVKKLIGKNPQKDINPDECVAIGAALQGGVLTGEVKDLLLLDVTPLSLGIETLGGVCTKLIERNTTIPTKKSQVFTTAADGQTSVEIKVLQGEREMAADNTLLGQFNLTEIPAAPRGVPQIEVTFDIDANGIVNVSAKDLGSGKQQAMTITSSTKMSDDEIKRKVDEASKYAEEDKNKKETIETKNSAESVIYQVEKTIKDLGDKVSETEKSDINSKIEALKSILDSGDNKDIKAKTDELTQEMYKLSSKLYENNAQQPGASQEAKKDDDVVDADYEVVDDDENK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FNBA_STAAB
Sequence: MKNNLRYGIRKHKLGAASVFLGTMIVVGMGQDKEAATSEQKTTTVEENGNSATDNKVSETQTTTTNVNTIDETQSYSATATEQPSNATQVITEEAPKAVQAPQTAQPANLETVKEEVVKEEEKPQVKETTQSQDNSGDQRQVDLTPKKATQNQAAETQVEVAQPRTVSESKPRVTRSADVAEAKEASDVTEVKGTDVTSKVTVTESSIEGHNNTNKVEPHAGQRAVLKYKLKFEDGLHQGDYFDFTLSNNVNTHGVSTARKVPEIKNGSVVMATGKILEDGKIRYTFTNDVEHKVEVTANLEINLFIDPKTFQSNGEEKVTSSLNGSKTEKNLQIEYKNGVGTYYANVNGSIETFDKEKNKFTHVAYVKPLNQFKLGTVTVSGTVTQGSNPNGEKPTVKIYEVTNDGKDLPQSVYLDASDKNKYKDVTNEMQSKLTVQENGNYTLNLDTLDKSYVIHYSGEYLNGTNEVNFRTQMFGYPEQRYGYYYNSYQLTWDNGLVLYSNKADGNGKNGQIIQNNDFEYKEDTLTETVTGQYDEKQIIETEENQDNTPLDIDYHTAIDGEGGYADGYIETIEETDSSAIDIDYHTAVDSEAGHVGGYTESSEESNPIDFEESTKGIVTGAVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPIEEITENNHHISHSGLGTENGHGNYGVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNIVDIDFDSVPQIQGQNNGNQSFEEDTEKDKPKYEQGGNIIDIDFDSVPQIHGFNKHNEIIEEDTNKDKPNYQFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPSEPETPTPPTPEVPAEPGKPVPPAEEEPKKPSKPVEQGKVVTPVIEINEKVKAVAPTKQKQSKKSELPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA
What is the function of this protein?
Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides and tropoelastin.  This confers to S. aureus the ability to invade endothelial cells.  Promotes adherence to and aggregation of activated platelets (By similarity).
What are the official names of this protein?
Fibronectin-binding protein A.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A (By similarity).
Protein: EFC4B_MOUSE
Sequence: MATPSGREDSSSQTPGHGKQGSGACVEQLDHPEKLEVEMPDQSAMWKKAQEFFQTCDSEGKGFIARTDMQRLHQELPLSLEELEDVFDALDADGNGFLTPEEFTTGFSHFFFSQNIQGEEEADQQVAQLQEEKVYQSRGEEDVGDMDHDEEAQFQMLMDRLGAQKVLEDESDVRQLWLQLRKDEPHLLSNFEDLLTTIFAQLQEAHEQKNELECALRKKIAAYDEEIQHLYEEMEQQIKSEREQFLLKDTERFQARSRELEKKLSAKEQELERLNQKQRKLEGQCAALHNDKHETKAENSKLRLTNQELARELERTSHQLQEAQQQLESLQREACELQQEKEMEVYRVTESLQREKSGLLKQLDFLRERNKHLRDERDITFQKDKAAKANTAASKASRKQRSGSVIGKYVDGRGILRSQSEEEEDVFSAPRRRSSVGLSAYLQAEEDLGTGEPGSGVPRRQALRRIISIEEDPLPQLLEGGFEKPLSRCPEEEEVSDQGTERQSVAAPVLDLIPTSPRGQPVGKETLYKEERVPSTPDRLFKIVFVGDSAVGKTSFLRRLCEARFSPGMAATVGIDYRVKTVTVDNAQVALQLWDTAGQERYRCISQQFFRKADGVAVMYDLTAKQSFLSIRQWLSSVEEAVGDRIPVLLLGNKLDNEKEREVPRGLGEQLAKENNLIFYECSACSGHNAQESLLHLARLLKEQEDTVRNDTIQVGPPAKKKSCCG
What is the function of this protein?
Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (By similarity).  During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (By similarity).  Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (By similarity).  Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526).  In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (By similarity).  Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160).  Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (By similarity).
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 4B, Calcium release-activated channel regulator 2A, Ras-related protein Rab-46.
What is the protein family that this protein belongs to?
Belongs to the EFCAB4 family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center. Cell membrane. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Vesicle. Note=T-cell activation-induced elevation of intracellular of Ca(2+) stimulates its transport toward the microtubule organizing center (MTOC). Histamine stimulation induces a trafficking to the MTOC in a GTP-binding-dependent but Ca(2+)- binding-independent manner. Localizes to Golgi membrane in resting T- cells and upon its interaction with VAV1, is translocated from the Golgi membrane to the immunological synapse via subsynaptic vesicles. Its localization in the Golgi membrane requires isoprenylation and GTP- binding.
Protein: BTBDG_MACFA
Sequence: MSNTHRARLERRIAGSTNRWRFPKQPFTGDLLSLSQMFKALSIDFEEALRNPDRLYISQIQKFFCENFKNKDIQSAEADVILECLGFKWELHQPQLFQSETLAKLYLKALMQGTTYPLRELEELLRAQSPKKTKEKSPAKRMIISLKINDPLVTKVAFATALKNLYVSEVEINLEDVLGVLASAHILQFSGLFQRCVDVMITRLMPSTIKNFYEAGCKYKEEQLTTACEKWLEMNLVPLVGMQIHLRKIPQDLLHKVLKSPRLFTFSEFRLLKTMLLWVFLQLNYKIQAIPTHETVMTFFKSFPENCCFLDRDIGQSLRPLFLCLRLHGITKGKDLEVLRYINFFPESWLNRVTANHYHALENGGDMDQLKDLNTQAVRFGLLFNQENTTYSKMIAVYGFFFKITGLRHDTTSYSFYMQRIKHTDMESPFVVYEHKPVSLRAARLVKYEIRAQALVDGKWQEFRTNQIMQKFGLTKPSCKSHILKIQTVGIPIYVSFAFIFPPS
What are the official names of this protein?
BTB/POZ domain-containing protein 16.
Protein: MT2X_SOLLC
Sequence: MSCCGGSCGCGSGCKCGNGCGGCGMYPDMEKSATFSIVEGVAPVHNYGRVEEKAAGEGCKCGSNCTCDPCNC
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-like protein type 2.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: OSPC1_BORBG
Sequence: MKKNTLSAILMTLFLFISCNNSGKGGDSASTNPADESAKGPNLTEISKKITDSNAFVLAVKEVETLVLSIDELAKKAIGQKIDNNNGLAALNNQNGSLLAGAYAISTLITEKLSKLKNLEELKTEIAKAKKCSEEFTNKLKSGHADLGKQDATDDHAKAAILKTHATTDKGAKEFKDLFESVEGLLKAAQVALTNSVKELTSPVVAESPKKP
What is the function of this protein?
Major immunodominant protein in mammalian hosts (PubMed:7665660).  Required for initial stages of mammalian infection (PubMed:14722614).  Exploits its interaction with Ixodes scapularis salivary protein 15 (Salp15) or its paralog I. ricinus Iric-1 to increase mammalian host infection.  Binding of bacteria to Salp15 or Iric-1 protects them from antibody-mediated destruction in vitro, due to interaction with this protein (PubMed:16049492, PubMed:18752445).  Preincubation with Salp15 or Iric-1 allows bacteria to infect mice that had already cleared a B. burgdorferi infection, showing it is important in bacterial colonization and dissemination (PubMed:16049492, PubMed:18752445).  Decreasing Salp15 levels in ticks by RNAi leads to decreased bacterial presence in infected mice (PubMed:16049492).  Inhibits macrophage-mediated phagocytosis of the bacteria.  Binds human (host) plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse host tissue (By similarity).
What are the official names of this protein?
Outer surface protein C.
What is the protein family that this protein belongs to?
Belongs to the OspC lipoprotein family.
Protein: RL2_PSEMY
Sequence: MAIVKCKPTSAGRRFVVKVVNQELHKGAPYAPLLEKKSKSGGRNNNGRITTRHIGGGHKQHYRLVDFRRNDKDGIPATVERVEYDPNRTAHIALLKYADGERRYIIAPKGVVAGDQLVAGNMAPIKPGNSLQLRNIPVGSTVHGIELKPGKGAQIARSAGASAQLIAREGAYVTLRLRSGEMRKVLAECRATLGEVSNSEHSLRSLGKAGAKRWRGVRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGFPTKGAKTRANKRTDNMIVRRRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RL30_SALPC
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAVRGMVNAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: ENDOV_MOUSE
Sequence: MAHTAAERPPEETLSLWKGEQARLKARVVDRDTEAWQRDPSFSGLQKVGGVDVSFVKGDSVRACASLVVLSYPELKVVYEDSRMVGLKAPYVSGFLAFREVPFLVELVQRLQEKEPDLMPQVVLVDGNGVLHQRGFGVACHLGVLTELPCIGVAKKLLQVDGLENNALHKEKIVLLQAGGDTFPLIGSSGTVLGMALRSHDHSTKPLYVSVGHRISLEVAVRLTHHCCRFRIPEPIRQADIRSREYIRRTLGQLGVAPAQRKDRSQKEQRPNACPQGGPGALADQGRPPECDGRDSSSDRKAPEPGFQEQKDQQLEGTGHQEDSDLWPPSPAWVQSPP
What is the function of this protein?
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine.  Active against both single-stranded and double-stranded RNAs.  Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs).  Cleaves mRNAs and tRNAs containing inosine.  Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'.  Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing.  Binds branched DNA structures.
What are the official names of this protein?
Endonuclease V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Cytoplasm, Stress granule. Note=Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with PABPC1.
Protein: IQCAL_HUMAN
Sequence: MSEGAYQRLWESSHATLQELLDQEQLLLEPAPDRERQSFQYRLASLYLHYLGLLRRFDTVYDQMVQPQKRRLLRRLLDGVAGRVLELKDELVRADLCENHCLDRVLQDFKLTPADLEVPIPKYFLLEQSTTVRERGLILAEILSRLEPVSSQKSFTGMHRTEAIILVQKAERARQGRLRATFMREIRRDEEQDGRIREDGWHKFSQGQAAVTIQKVWKGYLQRKRTQQDRRMEMEFIGMLPSPNQVEHLSIISQPCLVEDVQRLRQMEKEEEFRAAMVKAHDSLVETEGPDMKEKMKEQIRQWFIECHDLTGRFPDYPDASSGGSYSIFADKTPEQVRMELEMQMQENRKKEQEKSKEKGKDEKEKKKGKEEKAKKGEVDAVLQVLPSKCIPMICAGHEEYLNTWKNRCESIHPSQNYDSETLREEKRKEVELEIRIQVDELMRQELRKLRLAVDKEEERPLRAPKKTPGKKTGKKKEKDLTSDRSVESLYEELVISGLLRKSESVALKDYIGDFLYLGSTLSLVKKLPMPSLFDIRQNVALYAVLRLGSPDIHIMAPLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMMVHIVFKVARLLQPSVIWIGNAEKNFYKKTPKEDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRPQLAEMRGLCRVYERILFMPRPDYASRYVLWKRMIEARGIQPTQHLDISALAKVSDGYTPGHILQAIQSVLSERRFLQLSKRPLVASEFLGQLVKLDPVYREEEESLKDWYFKTPLGKKSMKHRMDQLEAEEAKLDKEKKKRK
What are the official names of this protein?
IQ and AAA domain-containing protein 1-like, IQ and AAA domain-containing protein 1 pseudogene 1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: RARB_COTJA
Sequence: MTTSSRTCPVPAVNGHMTHYPAAPYPLLFPPVIGGLSLPSLHGLQSHPPTSGCSTPSPASVETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEPTKQESTENYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTSLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPMKVDKLQEPLLEALKIYIRKRRPNKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPTSNGNTAEHSPSISPSSVDNSSVSQSPMVQ
What is the function of this protein?
Receptor for retinoic acid.  Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.  The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity).  May be required for Sertoli cell differentiation and spermatogenesis.
What are the official names of this protein?
Retinoic acid receptor beta, RAR-beta, Nuclear receptor subfamily 1 group B member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SUCC_BRUO2
Sequence: MNIHEYQAKRLLHTYGAPIANGVAVYSVEQAEEWAKTLPGPLYVVKSQIHAGGRGKGKFKELPADAKGGVRLAKSVEEVVANAKEMLGNTLVTKQTGEAGKQVNRLYIEDGADIERELYLSILIDRSVGRPAFVVSTEGGMDIEAVAEETPEKIVTVAIDPAKGVTDEDANKLADALKLEGGAREDGLKLFPILYKAFTEKDMSLLEINPLIVMTNGRVRVLDAKVSFDNNALFRHPDIVELRDLTEEDPKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGASKEKVTAAFKIITADPAVEGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLEGTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGN
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.