PharMolix/UniProtQA huggingface dataset:
Protein: HH_DROER
Sequence: MDNTSSVPWASAASVTCLSLDAKCHSSSAKSAASSISASPETQAMRHIAHTQRCLSRLTSLVALLLIVLPMTFSPAHSCGPGRGLGRHRARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCREKLNLLAYSVMNEWPGIRLLVTESWDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLENGVRKPLGELSIGDRVLSMTANGQAVYSEVILFMDRNLEQMQNFVQLHTDGEAVLTVTPAHLVSVWQAESQKLTFVFADRVEEKNQVLVRDVETGELRPQRVVKVGSVRSKGVVAPLTREGTIVVNSVAASCYAVINSQSLAHWGLAPMRLLSTLEAWLPAKEQLHSSPKVVTTAEQQNGIHWYANALYKVKDYVLPQSWRHD
What is the function of this protein?
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.  Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks.  Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc.  In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu).  Essential component of a signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection.  During photoreceptor differentiation, it up-regulates transcription of Ubr3, which in turn promotes the hh-signaling pathway by mediating the ubiquitination and degradation of cos.
What are the official names of this protein?
Protein hedgehog.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. SUBCELLULAR LOCATION: [Protein hedgehog N-product]: Cell membrane; Lipid-anchor. Note=The N-terminal peptide remains associated with the cell surface. Heparan sulfate proteoglycans of the extracellular matrix play an essential role in diffusion. Lipophorin is required for diffusion, probably by acting as vehicle for its movement, explaining how it can spread over long distances despite its lipidation.
Protein: NLRC5_HUMAN
Sequence: MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTFGYDDGFTSQLGAEGKSQPESQLHHGLKRPHQSCGSSPRRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQPHAFHQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRVNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQPQAPWGT
What is the function of this protein?
Probable regulator of the NF-kappa-B and type I interferon signaling pathways.  May also regulate the type II interferon signaling pathway.  Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
What are the official names of this protein?
Protein NLRC5, Caterpiller protein 16.1, CLR16.1, Nucleotide-binding oligomerization domain protein 27, Nucleotide-binding oligomerization domain protein 4.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED14_COCIM
Sequence: MPGLAMDGPSAMASRATVADMHYDPASASQQANGGIYRNGIGKKSHSPVDGLHDSHIGCLHELPPELSHITLGFFPFNNLISRVVQQSWNDLNELLNEMGSSQAYQTGISSQLSATKNGMSEKFRGDQATENSLKKLRILEFTHSRRAEFIKLLVLSQWSRQANEVSRLIDIQAFIRMRSGFYEAALFHIGNMKQNLIVAQLANPDLKTASHVLSAGKIDALHGLEFLSPRPLAPSQVLRLLRGINKLIDMRLALHDHVPDSLQNYFVHDGRVTFIVPNEFEIDLSVASAAPSAQFFLVDMKFLFFPSSLPKGRLRSIVDHQVNSTLMNAGLVGCFNLLHNLILTHKITILFKQAIDLARTYWSEHLRVELFHRTLVLQYWSKKPGGKSWIEIGVHSGLKGSPQSTGTTTSFLQLRWFRDNEEVSATDIDFNLTFLSAKSILFSAISLHITHILRTAFEALRQNRLYCLGGLYIGMSASSKEPGDCYLELQMTQTSHLDIMVEAVSGDTVLRVAPSPITRYDTEIIVDRGSVEDIVERVSRLRCVSALEEVERYAKAVGWMPLNLRHVNLESLKRIFPPSALRSMLLFRAKCWEPSWLAVFTSAMDGDNWWIVQLQTQNPPALQSHWRLLEAQRAKLITGWFTGWLGRLHNASFSSLLSALSGMIMVQCNVDFLNEIGAIHFFPPPKDLLLQPCLRVPSIYLRLRHDDFPSQFRTIFSGGSPRRSFIDETFRISYKGIDQQSGHAITMVYGRLMTDIDMFGALYAKSVQDIAFQPKGRGFAILFRTPVGTPIIAPLLERLQQMNNIAFVVESMKSQGFQPHSLSPLRIKFSYPTQGELRGSIKFIYHDQGSHFESKLLFPATTTKPILHPRIGIDFNYQNPHRRITESLSTILNSHKDGMSLVLELINITLPLLVTLERICAEEYIDNAWCFRAQYTARSARLYQIRYPFLRYRFNVSASQRKSYVVWVIQNSTPGPERSKHPSLELRLKDQIYNSQGDGWRGINQGAMAYSANVSRLVFDLHQLMKSYISQMAKSNQRGEPTDSSPSAGCEFGRYLPKNENKKGHIQTTTAPTLEHAYGNSNMVVQSVRQGEAAARDVDVIAID
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MUTL_BACVZ
Sequence: MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDANSTVIEIDIEEAGLSSIRVLDNGEGMETDDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPSIASVSHLEIKTSIGEGAGTHLILQGGNIISEQKSSSRKGTEIIVTNLFFNTPARLKYMKTVHTELGNITDVVNRIALAHPEVSIRLRHQGKNLLQTNGNGDVRHVLAAIYGTAVAKKMIPLHISSLDFEVKGYIALPEITRASRNYMSSVINGRYIKNFPLVKAVHEGYHTLLPIGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHELIRDGIKEVFQKQRLIPSAQLPKKSAPAPAKNEQQFMTFEESAPERKLPEKTPEPSYSPMKLSSVVKEPEPVIIEEEILPNEADHGVPPELGMPETAAPVSDTPEPEAVSEEIREERVPMMYPIGQMHGTYILAQNENGLYIIDQHAAQERIKYEYFREKVGQVEPEVQDMIVPLTFHYAANEALIIDQHQHELESVGVFLEAFGTNSYIVRCHPAWFPKGEEAELIEEIIQQVLDAKQIDIKKLREEAAIMMSCKGSIKANRHLRNDEIKALLDDLRRTTDPFTCPHGRPIIIHHSTYEMEKMFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: APAF_MOUSE
Sequence: MDAKARNCLLQHREALEKDIKTSYIMDHMISNGVLSVIEEEKVKSQATQYQRAAALIKMILNKDNCAYISFYNALLHEGYKDLAALLQSGLPLVSSSSGKDTDGGITSFVRTVLCEGGVPQRPVIFVTRKKLVHAIQQKLWKLNGEPGWVTIYGMAGCGKSVLAAEAVRDHSLLEGCFSGGVHWVSIGKQDKSGLLMKLQNLCMRLDQEESFSQRLPLNIEEAKDRLRVLMLRKHPRSLLILDDVWDPWVLKAFDNQCQILLTTRDKSVTDSVMGPKHVVPVESGLGREKGLEILSLFVNMKKEDLPAEAHSIIKECKGSPLVVSLIGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCVLWDLETEEVEDILQEFVNKSLLFCNRNGKSFCYYLHDLQVDFLTEKNRSQLQDLHRKMVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLDWIKAKTELVGPAHLIHEFVAYRHILDEKDCAVCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYRQAKLQAKQEGDTGRLYLEWINKKTIKNLSRLVVRPHTDAVYHACFSQDGQRIASCGADKTLQVFKAETGEKLLDIKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHTYDEHSEQVNCCHFTNKSNHLLLATGSNDFFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDELLASCSADGTLRLWDVRSANERKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDKIIVAAKNKVLLFDIHTSGLLAEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQTIRVWETKKVCKNSAIVLKQEIDVVFQENETMVLAVDNIRGLQLIAGKTGQIDYLPEAQVSCCCLSPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTGDYVFLQAHQETVKDFRLLQDSRLLSWSFDGTVKVWNVITGRIERDFTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFDLLSPLHELKGHNGCVRCSAFSLDGILLATGDDNGEIRIWNVSDGQLLHSCAPISVEEGTATHGGWVTDVCFSPDSKTLVSAGGYLKWWNVATGDSSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGILYILQVLE
What is the function of this protein?
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis.  This activation requires ATP (By similarity).
What are the official names of this protein?
Apoptotic protease-activating factor 1, APAF-1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPED_ECOUT
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTTEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPKLIDKTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDINGMKHFIDHEINSIQNFMSEDMKALYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTDSERQEITAALWKEMREIYYGRNMPAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: ARLY_SODGM
Sequence: MALWGGRFSQAADQRFKSFNDSLRFDYRLTEQDIVGSVAWSRALVTVGVLSETEQQQLEDALNVTLEEVRTAPEAILASDAEDIHSWVEQCLIDKVGDLGKKLHTGRSRNDQVATDLKLWCRAQVTELLGAIHLLQQALVMTAEAHQDVVMPGYTHLQRAQPITFAHWCLAYSEMLARDESRLRDTLTRLDVSPLGAGALAGTAYAIDRDKLAGWLGFASATRNSLDSVSDRDHVLELLSYAAIGMVHLSRFAEDLIFFNTGEAGFIELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQLKSPRCREAAQQGYANATELADYLVARGIPFREAHHIVGEAVVEAIRQGVPLETLPLARLQAFSPVIDEDVYPVLALASCLAQRKAKGGVAPEQIAQAIAEAKQRLA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_NICPL
Sequence: MEEIQRYLQPDRSQQHNFLYPLIFQEYIYALAHDHGLNRNRSILLENPGYNNKLSFLIVKRLITRMYQQNHFLISTNDSNKNSFLGCNKSLYSQMISEGFAFIVEIPFSLRLISSLSSFEGKKIFKSHNLRSIHSTFPFLEDNFSHLNYVLDILIPYPVHLEILVQTLRYWVKDASSLHLLRFFLHEYWNLNSLITSKKPGYSFSKKNQRFFFFLYNSYVYECESTFVFLRNQSSHLRSTSFGALLERIYFYGKIERLVEVFAKDFQVTLWLFKDPFMHYVRYQGKSILASKGTFLLMNKWKFYLVNFWQCHFSLCFHTGRIHINQLSNHSRDFMGYLSSVRLNPSMVRSQMLENSFLINNAIKKFDTLVPIIPLIGSLAKANFCTVLGHPISKPVWSDLSDSDIIDRFGRICRNLFHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRTFLKRSGSELLEEFLTSEEQVLSLTFPRASSSLWGVYRSRIWYLDIFCINDLANYQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RLMF_VIBC3
Sequence: MNTPLKPKHGQKTNQKPKANKPVVKKQQTKQPPTHKVQGEEVAAVKSGLHPRNRHRGQYDFPALIKVVPELQSHVMKNPKGQWTINFADPIAVKLLNKALLALHYGVTYWDIPEGFLCPPIPGRADYIHRVADLLLKENPKLNPSQVTALDIGVGANCIYPIVGVTEYGWSWVGSDVDPVSIQQASLIVQSNSKLQGHIEFRLQKNSQHIFNGIIGANERYTLTTCNPPFHASLADAQQGTQRKLTNLQANQRKKGRLATPTLSHSRLNFGGQKAELWCPGGEAAFIGKMAVESQQFAQQVLWFSTLISKGDNVRGMKKQLEKLGAQSIHVIEMAQGQKISRFIAWSFQNAEQRKLWWQAKC
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Putative ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_CERS5
Sequence: MTRSLHIVGAGMAGSEAAWQAAEMGVPVVLHEMRPRVGTFAHRTGQFAEMVCSNSFRSDDDERNAVGLLHWEMRAARGLIMEMASAHRLPAGGALAVDRDPFAESVTARLREHPLISVVDEELAELPSDGDWIIATGPLTSSSLAESIRAVTGAQSLAFFDAIAPIVYAESIDMSVAWRQSRYDKGETEDERTAYINCPMTRDQYEAFIDALLAAEKTEFHEGETAGYFDGCLPIEVMAERGRETLRHGPMKPVGLTNAHKPQDKAHAVVQLRRDNKLGTLYNIVGFQTKMKYGAQTSVFRMIPGLENASFARLGGIHRNTFLNSPTLLDDRMRLKLRPNIRFAGQVTGVEGYVESAAMGLLAGRMAAAEILGRDLPPPPPETAMGALITHITGGAEAKTFQPMNVNFGLFPPIDARGGRRGRKDRYKAYTHRAKAAFTEWLAA
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSY_SYNY3
Sequence: MFNWFRRQFGKDNTAPESAPPEGAEVSPELAPEVIQAETESPSEEDSQTTELAAPPPEEPSSDTANPDDYLQWAKAAYQNIQARKAETVSPPESAAAITVEAGIEETAEEIVVAPESDQATATEADLPSPETEITTGPAWLQKSDRLEALKETAVEEATVAGTLTAESMAMDDDFMWSAKVLAAQGRSAADVSAEEIDWLRKLRQGLSKTRVNLVNQLKSIVGQGPLNEAAVEEIEAILLQADVGVEATDYIITTLQDKLREEALPPEQAIEFLKEILRSILDRPLLSLPSAEFAPEAEGLNVWLLTGVNGAGKTTTIGKLAFMAKQSGYDCVIAAADTFRAAAVEQVKVWGERSGVPVIANPGQNTDPAAVVYDGISAAQSRNVNLLLVDTAGRLQNKKNLMDELAKIRRIIDKKAPNATVESLLVLDATLGQNGLRQAEVFAEAAKLSGVVLTKLDGSAKGGVALAVAQQLNLPIRFIGAGEGIEDLRPFSSYEFVEALLNG
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
What are the official names of this protein?
Signal recognition particle receptor FtsY, SRP receptor.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. FtsY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: BRP_HALS3
Sequence: MSNRSQFVPSWLVPEAAGDLPLTVSRLSLLALAAAFAVGYGAGFAVPLEVQAGVYLLGMVAMNLPHGGYEHFENLRRRAASFQGKYIVAYLVGIAAFGALFFVAPVAGLGLAVTVAVAKGGFGGVQSMDALYGTDHLRTRPQRWLAAVVRGGAVMVVPMLFWTDVFYAFSSVMISIFDPSAVSALGGDIATRRLVLGGGYGALVVAHLGLGYRRAAGTGSFLADAAETLLLIAYFALVPVVIAVGLYFPLWYSARQVARSSAVDDTAMTQADATGMLDALDADDPARATLASWAVLIVGSVATFGLAAVLWLLSPQPLGGGGILVGLVAFWSIFVSIIALPHVVVGGWLDRTRGIWYVP
What is the function of this protein?
Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
What are the official names of this protein?
Probable beta-carotene 15,15'-dioxygenase Brp, Bacteriorhodopsin-related protein.
What is the protein family that this protein belongs to?
Belongs to the Brp/Blh beta-carotene diooxygenase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PB2_I75A0
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMVPERNEQGQTLWSKMXDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKVYKTYFDKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDIDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMVGVLPDMTPSTEMSMRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETHGTERLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKTTKRLTILGKDAGTLIEDPDESTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: GLYA_STUS1
Sequence: MFSRDLTLARFDADLFAAMQQEAKRQEDHIELIASENYTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHAGSQANAAVYLALLSAGDTILGMSLAHGGHLTHGASVSSSGKLYNAVQYGINDQGLIDYDEVERLAVEHKPKMIVAGFSAYSQKLDFARFREIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILAKKNEEIEKKLNSAVFPGAQGGPLEHVIAAKAVCFKEALQPEFKAYQQQVVKNAQAMAEVFIQRGFDVVSGGTQNHLFLLSLIKQDITGKDADAALGRAHITVNKNSVPNDPRSPFVTSGLRIGTPAVTTRGFGEAECRELAGWICDILDNMGDESVIDAVRGKVEAVCAKFPVYGN
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
Protein: RPOB_NASOF
Sequence: MLGDGKEGTSTIPGFNQIQFEGFYRFIDQGLIEELSKFPKIEDIDHEIEFQLFMETYQLVEPLIKERDAVYESLTYSSELYVSAGLIWKTSRNMQEQRIFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYQSELDHNGISVYTGTIISDWGGRLELEIDKKARIWARVSRKQKISILVLSSAMGSNLREILENVCYPEIFLSFLTDKEKKKIGSKENAILEFYQQFSCVGGDPIFSESLCKELQKKFFHQRCELGRIGRRNINWRLNLNIPQNNIFLLPRDILAAADHLIGMKFGMGTLDDMNHLKNKRIRSVADLLQDQLGLALSRLENVVKGTISGAIRHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTANFRIRDIHPSHYGRICPIDTSEGINVGLIGSLSIHARIGDWGSLESPFYELFEKSKKARIRMLFLSPSQDEYFMIAAGNSLALNRGIQEEQAVPARYRQEFLTIAWEEVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVPAIAEHEGKILYTDTEKIVFSGNGDTLSIPLIMYERSNKNTCMHQKPQVRRGKCIKKGQILADGAATVGGELALGKNILVAYMPWEGYNFEDAVLISECLVYGDIYTSFHIRKYEIQTHVTTQGPERITKEIPHLEGRLLRHLDKNGIVMLGSWVETGDILVGKLTPQVAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWVQKKGGSSYNPEIIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQIFECSLGLAGSLLDRHYRIAPFDERYEQEASRKLVFSELYKASKQTANPWVFEPEYPGKSRIFDGRTGDPFEQPVIIGKPYILKLIHQVDDKIHGRSSGHYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPKPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FPR3_GORGO
Sequence: METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFIFGVLGNGLVIWVAGFLMTRTVNTICYLNLALADFSFSAILPFHMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIALDRCICVLHPAWAQNHRTMSLAKRVMTGLWILTIVLTLPNFIFWTTISTTNGDTYCIFNFPFWGDTAVERLNVFITMAKVFLILHFIIGFSMPMSIITVCYGIIAAKIHRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPILYVFLGSNFQERLIRSLPTSLERALTEVPDSAQTSNTHTTSASPPEETE
What is the function of this protein?
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors.  Binding of FMLP to the receptor causes activation of neutrophils.  This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
N-formyl peptide receptor 3, FMLP-related receptor II, FMLP-R-II, Formyl peptide receptor-like 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TCPZ_BOVIN
Sequence: MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.  The TRiC complex plays a role in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit zeta, TCP-1-zeta, CCT-zeta, CCT-zeta-1.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURP_METBF
Sequence: MITKQQVLEFLKNYDLENITIATICSHSSLQIFDGARKEGFRTLGICVGKPPKFYEAFPKAKPDEYLVVDSYADIMNKAEELRQKNTIIIPHGSVVAYLGTENFADMAVPTFGNRAVLEWESDRDKEREWLLGAGIHMPGKVDDPHDINGPVMVKYDGAKGGKGFFVAKTYEEFEELIDRTQKYTIQEFITGTRYYLHYFYSPIRNEGYTLSKGSLELLSMDRRVESNADEIFRLGSPRELVGAGIRPTYVVTGNMPLVARESLLPLIFSLGERVVEESLGLFGGMIGSFCLETVFTDTLEIKVFEISARIVAGTNLYISGSPYADLMEENLSTGRRIAREIKIAAQTGQLDKIIS
What is the function of this protein?
Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
What are the official names of this protein?
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: Y267_MYCGE
Sequence: MTLLFKLVKIAILVFLMVIGFFIFIGSFWLNTYQTAQWADLLASSDASGIILTIFPNINSWFNATVANQPVLFKTMVHFFIPVGFGLLFGLIIAIIVDILYRLTKYAIKRSYQSN
What are the official names of this protein?
Uncharacterized protein MG267.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.