PharMolix/UniProtQA huggingface dataset:
Protein: CD1B3_CAVPO
Sequence: MLLLELVFFAVLFPVGDTQDAFQEPISFHITQITSFVNSSWVKYQLSGWLGDLQIHGMDSDSGTAIFLKPWSKGNFSNEEMSEVVELFRVYIVAFIRETKAHVNALQMEYPFEIQGIAGCELHSGGAIVSFLQGAFGGLDFVSFKNSSCVPAPEGGSRAQTVCKLLAPYHDIFYTVEKLLYETCPQYLLGVLQAGKADLHRQVKPKAWLSSGSTHEPGHLQLVCHVSGFYPKPVWVMWMRGEQELPETQRGDILPNADGTWYLRVTLDVVTEEATGLSCRVKHSSLGGQDIVLYWGHSNPIGWVILAIVSCLIFFLCFALWYFRRLRCEGIF
What is the function of this protein?
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
What are the official names of this protein?
T-cell surface glycoprotein CD1b3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. Localizes to cell surface lipid rafts (By similarity).
Protein: RHBL6_TOXGO
Sequence: MKKSAGPFIASWRPFVGLPVSLERGRTFSRVLGICTYTPAIRRQMLLSGVSVIPPPLSKNFFRHAHLTGFSPFRSSCRRLFAQNGSDVAPLVSRIPNQSVAPGDTQWSVSPMGVHCEHWLKTRCLPGLPAAVFGSHQQVEAALLQRGLSPAKDASERVRSATREDLVRRERPTSEAGSHPPLPSRSSVSAFQLRSRCDPAVSGPSDSAPCGLSQTSFSLRSSSSSGATTRFSVPAVCPVFLCRSLPRLSGRFSRTRFGKQRKRTEEQEDSKDFDTGPLSSGSIFTVLVGSLLFFDVLRSGLYEHRKLLGAFLMTNAAVFTGWRLAATAGNGTWWTFLMRHFVLCRENLARARIYTFVTSSLSHKSTGHLIFNLFVINQLFRLLSFDLSDRDFASLFGLAALCGGLGHLLVSRQPVLGASAFAYALLWTEATRHSREMFRILPIPFFPLTALQLVQVAMCLEAAMAFLARPAFLARFPASRLLRFAQGISWSGHLGGLAAGCLYSWYKRRVEGDRSWQSFSELCRTYGTSDW
What is the function of this protein?
Putative serine protease involved in intramembrane proteolysis and the subsequent release of polypeptides from their membrane anchors.
What are the official names of this protein?
Rhomboid-like protease 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYCT_YERPE
Sequence: MQTTFTELMQQLFLKLGLNHQVNENDVYTFTFEVDGHIQVLIACYHQQWVQLFSELGADLPTNDNLFGEHWPAHVQGRLDGKPILWSQQSLVGLDIDEMQAWLERFIDDIEQRKEPQNTKFQPNSTSPILFI
What is the function of this protein?
Functions as a specific chaperone for YopT.
What are the official names of this protein?
Chaperone protein SycT.
Protein: SYI_CYAP4
Sequence: MTEPGSYKETVNLPQTAFDMRANAVKREPELQKFWAENQIYENLSQENPGDPFILHDGPPYANGDLHIGHALNKILKDIINKYWMLQGRKVRYVPGWDCHGLPIELKVLQGMKSEQRAALTPLSLRQAAKEFALQTVERQKQSFKRYGVWGEWDNPYLTLKPEYEAAQIGVFGQMVLKGYIYRGLKPVYWSPSSQTALAEAELEYPEGHTSRSIYVSFALTSLSATAEAVLKDYLPNLKVAIWTTTPWTIPGNLAVALNPDLTYAVVEKDGSYLLVANELVERLETTLGVSLPIKTTIAGQALEHSTYQHPLFDRQGPLVMGDYVTTDSGTGLVHTAPGHGQEDYVVGQHYGLPILSPVDGNGRFTEEAGQFAGLKVLDEGNEAVIQALQQVGALLKEEAYSHKYPYDWRTKKPVILRATEQWFASVEGFREAALQAIAQVQWIPAQGENRITAMVSERSDWCISRQRNWGVPIPVFYDEETGEPLLNAETIAHVQAIVAEKGSDAWWELSIEELLPQAYRNNGRRYRKGTDTMDVWFDSGSSWAAVLEQREQLRYPAEMYLEGSDQHRGWFQSSLLTSVATHGIAPYKTVLTHGFVLDEQGRKMSKSLGNVVDPAIVIEGGKNQKEDPPYGADILRLWVSSVDYSSDVPLGKNILKQMADIYRKIRNTARFLLGNLHDFDPANNKVEYDRLPQLDRYMLHRIVEVFTEVNEAFTSYQFFRFFQTVQNFCVVDLSNFYLDIAKDRLYISAPDDFRRRSCQTVLWIALENLAKAIAPVVPHLAEDIWQFLPYPTPYKSVFEAGWVSLDATWTNPDPQLLETFEQVRLLRFKVNECLEKLRVNKVIGASLEAKVLLYIADPEKRQQWQNLNPPALAAISGVDELRYFFLTSQVELLNSPDQLSELKSEYRFEFGDSSGGVLPADGQKCDRCWNYSTYVGKDDKHLLLCERCVAVMER
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_SHESH
Sequence: MSLQIDAVILAGGMARRMGGNDKGLVELQAQPMIKHAIDRIKPQVREILINANRNQTRYAEFGYQVISDEDSGYLGPLAGMITAMGQTQAKYLLVVPCDCPLLPADLVERMLSQLEKENADLAVASDGKREQPVVLLLKPELRDSMKAFLDAGERKIDFWYAKHNCAVADFSDQPNAFVNVNTPEQKQQLSEAIAK
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBE_CUSRE
Sequence: MSGNTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTESRQGIPLITGRFDSLEQLNEFSRSF
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid membrane; Single-pass membrane protein.
Protein: BTCA_COLOR
Sequence: MTTIWEHCVDVDGEVAASTGCFTTLPIRIHRRNDIADDATKQSIHDWGAYVGDGWEQRSGSSWSPVGNWGAFIFPESLPDRLGVITYLANMGNIHDDLCDELPFEEALKEHSNLSQAMEVSNSDTRQCSKASDRSMKMKKYISKCLLEAMEIDRARALRMINSYRSKWLDVMESQNVNDMQTLEEYLAFRNLNGGMEAFWSMVEFGMAIDISESEKTHTRPLFQAAESALVLTNDYWSWDREWRLAQRTQDPRIVNAVHLFMRTEGLSVDQAREKVRERIVDYEREYLRLKEEFYTQNPNLPLYLRRYVEVCGVITAGNHYWCANCPRHHAWRDEESSPSERSFSPSNEGIEDPRLSPGASTTSSMSQKSSPATEITLSDVLGFMAINDNHKPQRSSDMALMAPVQYIRSMPSKGLRSLMVEALDQWLLVDDPELEQIKNIIDLLHNSSLILDDIEDDSPLRRGLPATHTVFGQAQSINSANFMFVQAVQMTQKLNNPASLDTLLDELECLFIGQSWDLYWKFHLQVPTEKEYLEMVDCKTGAMFRLLARLMFHESSVVSGTQVLQLLDEMCRLFGRFFQIRDDFMNLYSTEYSDQKGFCEDLDEGKMSYPLIMLLWQNPGQRDQIMGIFRQQASNTSRGPTSDRSRLPLETKRYVMSLLKGSDIMASTLRKLRDLEAAVDYSISGLEKALGDANPVMRIVLSRLSVRDVSL
What is the function of this protein?
Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of betaestacins (Ref. 3).  The bifunctional terpene synthase btcA converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into the sesterterpene betaestacin I (Ref. 3).  The C-terminal prenyltransferase (PT) domain of btcA catalyzes formation of GFPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GFPP into betaestacin I (Ref. 3).  The cytochrome P450 monooxygenase btcB oxidizes the C25 methyl group of betaestacin I to yield the carboxylic acid betaestacin IV via the alcohol betaestacin III (Ref. 3).  The cytochrome P450 monooxygenase btcC further catalyzes the multistep oxidation of betaestacin IV to produce several compounds, including betaestacins Va, Vb, Vc and VI (Ref. 3).
What are the official names of this protein?
Sesterterpene synthase btcA, TS, Betaestacins biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the FPP/GGPP synthase family.
Protein: Y1044_MYCSS
Sequence: MARSDEDTWDLASSVGATATMVAAARAVASRGPDTLIDDPYADALVRAVGVEYFVKLLDGEITLEADNAAMLAVMTDVMAVRTRFFDDFFLSSGLPQAVILASGLDARTYRLPWPSGSVVYEIDQPEVIEFKTRTLADLGASPAAELRTVAIDLRDDWPRALRDRGFDPTAPTAWIAEGLLIYLPPDAQDRLFDNITALSAPGSRLATEFHPDAGARIGASSQRMAEEWRRHGLDLDMADLFYDGERNPVVDYLRERGWEVEARSRPDMFAHYGRPFPTGEAVEALRQSLAVTATRR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mmcs_1044.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: FUB9_FUSO4
Sequence: MSRTNLPIQPAKMSDATSSKPQIFSIQDLKQAASDKMSQMYRDYYNGGAMDNITLASNEAAFDRYLLRPRVLRNVSNIDMTTTLWGTKAALPLGVSPSAMHRLAHADGEVGTSKACAARNVPMILSALSNDTLEDVSGQSSDGSTPYAIQVSPFKNRQITTNLLSRAKAAGYKAVVLTVDAPMFGRRLDDLRNGFSIPPGFSFPNLSAQTQSGSGGLGGGIPDLSFDTAATWEEKIAWMKSQTDLEIWVKGVTSPLDAQIAIEQGVDGIIISNHGGRQLDTTPATIDILREIAPIAKGKTRIAIDGGFRRGSDIFKAVALGADFVFVGRIAIWGLAYDGSNGVGLALDLLINEFKLCMGLAGCSKISDITPAHLSILNAKGVLESVY
What is the function of this protein?
Oxidase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:25372119).  L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (By similarity).  The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (By similarity).  FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (By similarity).  Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the sulfhydrylase FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (By similarity).  Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (By similarity).
What are the official names of this protein?
Oxidase FUB9, Fusaric acid biosynthesis protein 9.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Protein: RETO_PAPSO
Sequence: MMCRSLTLRFFLFIVLLQTCVRGGDVNDNLLSSCLNSHGVHNFTTLSTDTNSDYFKLLHASMQNPLFAKPTVSKPSFIVMPGSKEELSSTVHCCTRESWTIRLRSGGHSYEGLSYTADTPFVIVDMMNLNRISIDVLSETAWVESGATLGELYYAIAQSTDTLGFTAGWCPTVGSGGHISGGGFGMMSRKYGLAADNVVDAILIDSNGAILDREKMGDDVFWAIRGGGGGVWGAIYAWKIKLLPVPEKLTVFRVTKNVGIEDASSLLHKWQYVADELDEDFTVSVLGGVNGNDAWLMFLGLHLGRKDAAKTIIDEKFPELGLVDKEFQEMSWGESMAFLSGLDTISELNNRFLKFDERAFKTKVDFTKVSVPLNVFRHALEMLSEQPGGFIALNGFGGKMSEISTDFTPFPHRKGTKLMFEYIIAWNQDEESKIGEFSEWLAKFYDYLEPFVSKEPRVGYVNHIDLDIGGIDWRNKSSTTNAVEIARNWGERYFSSNYERLVKAKTLIDPNNVFNHPQSIPPMMKFEEIYMLKEL
What is the function of this protein?
Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack.  Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine.  Involved in the biosynthesis of sanguinarine.
What are the official names of this protein?
Reticuline oxidase, Berberine bridge-forming enzyme, BBE, Tetrahydroprotoberberine synthase.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle.
Protein: ACT1_ONCVO
Sequence: MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEALFQPSFLGMESAGIHESTYNSIMKCDIDIRKDLYANIVLSGGTTMYPGIADRMQKEVTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQVWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin-1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RS2_RHOP5
Sequence: MALPEFSMRQLLEAGVHFGHQSHRWNPKMAEYIFGARNNIHIIDLAQTVPLLHNALKAVSDTVAKGGRVLFVGTKRQAQDVVADAAKRSAQYFVNSRWLGGTLTNWKTISASIKRLRHLDEMLNSGDAGSYTKKERLTLQRERDKLDRSLGGIKDMGGLPDLLFVIDTNKEDIAIQEAQRLGIPVAAIVDTNCDPKGISYLVPGNDDAGRAITLYCDLVARAVIDGLSRAQGDSGYDAGAMAQPLREELPVVAEARFQGLAGPRGVADDLKKLTGVSGAIEKKFNDLGIFHFWQLAELDHDTAHKISEEVGLPSRADAWVAQAKTLTEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PURR_PHOPR
Sequence: MATIKDVARMAGVSTTTVSHVINKTRFVAEATQKKVLAAVDDLNYAPSAVARSLKCNTTKTIGMLVTKSTNPFFAEVIHGVEEYCYNAGYTLILCNTEGNLVKQRDYLRMLAEKRVDGLLVMCSDIDQDLLDLLARKSDLPMVIMDWGPESPLTDKIQDNAEQGGYVATKHFIDNGHEKIGCLSGHSEKSTCRERLKGFNKAMAEAGITVNNNWIIDGDFECESAVEAANQYIAMKDRPTAIFCFNDIMAMALISTFEQAGVRVPDDISVIGYDNIDLAPYFSPPLTTIHQPKRRLGKTAIEILMERVKDKNHERRVFEMNPELVIRKSVKDLN
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: SMP18_NAUMA
Sequence: DSSVLTSEYPR
What are the official names of this protein?
Uncharacterized protein SMPP18.
Protein: Y2563_CLOBH
Sequence: MSGDKTIQFDPVENKKTLTKEILTKVYNSLLEKGYNPVNQLVGYLISGDPTYITNYNGARSLVIKLERDEILEEVIKSYLGIN
What are the official names of this protein?
UPF0297 protein CBO2563/CLC_2434.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: FOXD4_RAT
Sequence: PAKPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPASQDMFDNGSFLRRRKRFKR
What are the official names of this protein?
Forkhead box protein D4, Forkhead-related protein FKHL9, Forkhead-related transcription factor 5, FREAC-5, Hepatocyte nuclear factor 3 forkhead homolog 6, HFH-6.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRB_AKKM8
Sequence: MNHPRKDLLNISSLTDEEIHTLLDSAGPMKELFTKSVKKVPALKGKSVLTLFYEPSTRTRSSFEVAAERLSADVTNFTVSTSSVVKGESVQDTIATLQAMKVDYVIVRHYNSGLPNVIARHTCASVVNAGDGAHAHPSQALLDSFTIREVFPDVRGKRVLIVGDILHSRVARSTSLLMKRLGMEVAFLGPGSLVPRTEHSGIPRFSDFNEAFAWKPDVIYLLRVQKERQDAPFFPSAREYNKIYGVTEERLKRISGEGLYIMHPGPVNRGVEICDLAMDYERCLINRQVENGIACRMSILYHLTPQTQH
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL3_DELAS
Sequence: MSLSNSLGLLGRKVGMMRLFTDDGDAVPVTVVDVSNNRVTQVKTQENDGYVALQVTFGSRKASRVTKPEAGHLAKAGVEAGEVMGEFRVTEETAGKYAAGSVLPVAELFSVGQKVDVQGTSIGKGFAGTIKRHNFRSQRASHGNSRSHNVPGSISMAQDPGRVFPGKKMTGHMGDETITTQNLDVVRIDEARQLLLIKGAVPGSKGGFVTVRPAIKAKASKGAN
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: BRK1_ARATH
Sequence: MAKAGGITNAVNVGIAVQADWENREFISHISLNVRRLFEFLVQFESTTKSKLASLNEKLDLLERRLEMLEVQVSTATANPSLFAT
What is the function of this protein?
Involved in regulation of actin and microtubule organization.  Part of a WAVE complex that activates the Arp2/3 complex.
What are the official names of this protein?
Protein BRICK 1, AtBRK1.
What is the protein family that this protein belongs to?
Belongs to the BRK1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: OPSB_BOVIN
Sequence: MSKMSEEEEFLLFKNISLVGPWDGPQYHLAPVWAFHLQAVFMGFVFFVGTPLNATVLVATLRYRKLRQPLNYILVNVSLGGFIYCIFSVFIVFITSCYGYFVFGRHVCALEAFLGCTAGLVTGWSLAFLAFERYIIICKPFGNFRFSSKHALMVVVATWTIGIGVSIPPFFGWSRFVPEGLQCSCGPDWYTVGTKYYSEYYTWFLFIFCYIVPLSLICFSYSQLLGALRAVAAQQQESASTQKAEREVSHMVVVMVGSFCLCYTPYAALAMYIVNNRNHGVDLRLVTIPAFFSKSACVYNPIIYCFMNKQFRACIMEMVCGKPMTDESELSSSQKTEVSTVSSSQVGPN
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity).  Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity).  Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity).  May increase spectral sensitivity in dim light (By similarity).
What are the official names of this protein?
Short-wave-sensitive opsin 1, Blue cone photoreceptor pigment, Blue-sensitive opsin, BOP.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Cytoplasm, perinuclear region.
Protein: MDTH_ECOLI
Sequence: MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCLLSGLGGTLFDPPRSALVVKLIRPQQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLCAAFNAWLLPAWKLSTVRTPVREGMTRVMRDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDVAGAPSAVKWMYAIEACLSLTLLYPIARWSEKHFRLEHRLMAGLLIMSLSMMPVGMVSGLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDLGKSAHQPELPWMMLGIIGIFTFLALGWQFSQKRAARRLLERDA
What is the function of this protein?
Confers resistance to norfloxacin and enoxacin.
What are the official names of this protein?
Multidrug resistance protein MdtH.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: U17L2_HUMAN
Sequence: MEDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSEARVDLCDDLAPVARQLAPRKKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTPPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGHYFSYVKAQEGQWYKMDDAKVTACSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDERLVERATQESTLDHWKFPQEQNKTKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESVNTGTLASLQGRTRRSKGKNKHSKRALLVCQ
What is the function of this protein?
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.  Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation.  In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression.  Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation.  Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration.  Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 17, USP17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, DUB-3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP17 subfamily.
What are the subcellular locations of this protein?
Nucleus. Endoplasmic reticulum.
Protein: FOLD_BACC1
Sequence: MVAVIIKGNEVAEKKRAQLTEEVVKLKEQGIVPGLAVILVGEDPASRSYVKGKEKGCEQVGIYSELIEFPETITEERLLAEIDRLNGDDRINGILVQLPLPKHIEEKAIIERISPEKDVDGFHPISVGRMMTGQDTFLPCTPHGIVELVKETNLDISGKHVVVIGRSNIVGKPVGQLFLNENATVTYCHSKTQNMKELTKLADILIVAVGRPKMVTADYLKEGAVVIDVGVNRLETGKLCGDVDFDNVLDVAGYITPVPKGVGPMTITMLLHNTVESAKRAGVVCK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: DAPA_XYLFT
Sequence: MSLSGIITALVTPFDRDGAFDRDAWIRLLDMQLAGGVQGVVIAGSTGEAATLTDAEYDEMLCSAVVRVGGRVPVLAGTGLSGTAKTISQTKRAADNGAGYALVVTPPYIRPNQGGLKAHYLAVAEQGGLPVVLYNVPSRTGCDLLPETVADLAGHPNIVGIKEACASRERVQALLALRRPGFAVFSGDDSSAARSMLDGADGLVSVASNVLPSAYRHLCDLARAGERGAIDLWNARLSDFHAFCGLDSNPIPIKALLQRIGIGYGLRLPLLPLSVCHHDIADHLADQVAALEALSSRKIVTA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MORC3_MOUSE
Sequence: MAAQPPTGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVISDHICLTFTDNGNGMTADKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAMVFTKNGETMSVGFLSQTYLEVIKAEHVVVPIVTFNKHRQMINLTESKASLAAILEHSLFSTEQKLLAELNAIMGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDETAGRKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIIIRGQKVKTQLVSKSLAYIERDVYRPKFLTRTVRITFGFNCRNKDHYGIMMYHKNRLIKAYEKVGCQLKANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTILALGEKLNDYWNEMKVKKNAEYPVNLPVEDIQKRPDQTWVQCDACLKWRKLPDGIDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTSKERFRIRQPEILPRILPQINPELLYQTSVSSQSFSPVKESVPRPHLSEVTSPFAARIINLNLASPASEPENSSMKRKLGVHSSILNAKTRRLSNPPVENSSYKNDDDEDVIILEENSTPKPAVDLEVKSDIEVKSEQSHTEQSGIHVDLVSSPKPCVQASSTSTSTSRSDPGITVSTQTDAPGLTVKKEESMEEDMGVRNGTATLSCVGTEAKVQETSAESVDATSHQLQELRSELLVVTQERDDYKRQCQMFTDQIQVLQQRLLEMNDKCVKKEKCHQSTETDAVFLLDSVNGQAESLDHLGSQYQQALQEIERLKRQCSALQQVKSECSQASCTESKSEVDEMAVQLDDVFRQLDKCTIERDQYKNEVQLLEIEKSHIHSQCEELQTEVEQLKSTGQQAAADGSTASNAEEPVSYVDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST
What is the function of this protein?
Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response.  Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function.  Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504).  Binds RNA in vitro.  Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3.  The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.
What are the official names of this protein?
MORC family CW-type zinc finger protein 3, Nuclear matrix protein 2, Zinc finger CW-type coiled-coil domain protein 3.