PharMolix/UniProtQA huggingface dataset:
Protein: NUON1_STRGG
Sequence: MGMSVNSDPAALVPEITLLVSAVTGLLAGAWTPRERQGTIHVLAALATVVGLVATALAARQPDETVFGTYVLDTATHTTRAIVLVAVLALIALSRDTVAGHKRETEFVVLLQLGALGSIALAGAGDLIMLFAAFLLASVPFYALAGWAKQGRATEAALKYYLAGALAGVTTAAGVTILFGVAGATDYEKVADGISRGPAAAAAVGLIAVLAGLAFKAGAVPAHFWVPDIAEGTPPPVAAALTTVPKIGALVAFYRLLDTAIPAAAIDWRLITAVLATAGMTLGNLAAFAQTSALRMLGYSTVSQVGYLLMAVAVAGRTPLAQPALLLYLAAYALTNIAGFAVVATTHEHRIDRYRGLFHRDPLLALALTVALLGLVGTPPTAVFVGKLEIFTAAMDGGLAWLVVIAALNTLASLFYYLRWITPAFRPAEDDSAAVTPPSRWARAVALTTAALTLLLGIGSGIVLNALGASG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N 1, NADH dehydrogenase I subunit N 1, NDH-1 subunit N 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1846_PSEA7
Sequence: MINYLWFVLAAFCEIAGCYAFYLWLRLGKSALWVLPGLLSLSLFALLLTRVEASYAGRAYAAYGGIYVAASLFWLAFVERSRPLWSDWLGVALCVLGASIVLFGPRLSQ
What are the official names of this protein?
UPF0060 membrane protein PSPA7_1846.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACP_JANSC
Sequence: MSDIAARVKKIVVEHLNVDEDKVVDSASFIDDLGADSLDTVELVMAFEEEFGIEIPDDAAETIQTFGDATKFISEAQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IKZF1_ONCMY
Sequence: MEMEEAQEMSQMPGRDSPPPNDVSEENDEAMPIPEDLSASSNLQHNNRGDKEGLACNIKVEARCDEENGLAIDMMMNGEEEEECAEDLRVLDASGAKVNGSHAGGPDSKGPYSSAGGIRLPNGKLKCDICGIVCIGPNVLMVHKRSHTGERPFQCTQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALSGHLRTHSVGKPHKCAYCGRSYKQRSSLEEHKERCHNYLQCMGLQNSIYTVVKEESNQNEQREDLSQMGSKRALVLDRLANNVAKRKSTMPQKFVGEKRFSNISFEGGPGELMQPHVIDQAINSAINYLGAESLRPLIQTSPTSSDMGVMGSMYPLHKPPAEGHGLSAKDSAAENLLLLAKSKSASSEKDGSPSHSGQDSTDTESNNEEKAGVGASGLIYLTNHITSGVRNGVLPLVKEEQQRQYEAMRASIEIASEGFKVLSGEGEQVRAYRCEHCRILFLDHVMYTIHMGCHGFRDPFECNLCGHRSQDRYEFSSHMTRGEHRY
What is the function of this protein?
Binds and activates the enhancer (delta-A element) of the CD3-delta gene.  Functions in the specification and the maturation of the T-lymphocyte.  Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development.  Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).
What are the official names of this protein?
DNA-binding protein Ikaros, Ikaros family zinc finger protein 1.
What is the protein family that this protein belongs to?
Belongs to the Ikaros C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COFE_METBF
Sequence: MKFEAIAVENIPLIHTGDDLPSIICKNLELQDRDIVIVASTIVAKAEGKVFRLEDITPGKVALEMASRNGKDARFIQAVLSLSREVLVEKPFMLVTTLAGHTCVNAGIDESNIEDGFLLYPPENSDASASRLGQELETLSGKKLSVIVTDTNGRAFKIGQTGAAIGIYKIKPVKHWIGEKDLFGKVLEVAEEAIADELAGAANLLMGEGAGGTPVVVIRGFDYYCEEETFIKEMYRPEEMDVIKKGLRCLQKRVE
What is the function of this protein?
Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
What are the official names of this protein?
Coenzyme F420:L-glutamate ligase, Coenzyme F420-0:L-glutamate ligase, Coenzyme F420-1:gamma-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the CofE family.
Protein: SYNM_SCHPO
Sequence: MNKFQLPKTLKSLWHHPHNGELISINGWVRSIRKLKNVCFAMVSDGTCQQALQVVTSPEQSKKLSYGASVNIEGQLAVSKNAKLGLQQYELLAEKIKIYGQINDDNYPIQKKHLTTEMLRQIPHLRLRTAKQGEIFRLRSDSLKALRQFFSSKDFTETNPPIITSSDCEGAGEVFTLTPQETHKNKSFERDDQKHFFDRPAFLTVSTQLHLEALALGLSRVYTISPAFRAEQSHTSRHLAEFWMLEAEVAFMTSLSQLTSLMEDMIKYTLNSLMEQNYHRDHWDQLLKPWKCMTYSEAIEELSAVKKTWKYPPKWGNDLSSEHEKYLCEILHKTPVFVTDYPQKIKPFYMKSSGPDTVAAVDLLVPQVGELAGGSLRKDHLDEYKTYPPELQWYLDLMKYSNAPHGGFGLGIERLIAFLEGENTNVKETIPFPRSVGSIFA
What are the official names of this protein?
Asparagine--tRNA ligase, mitochondrial, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1478_STRPQ
Sequence: MTWKIVTDSGCDLRSLTRQSKELRFERVPLTLQIGTEIFRDDDGLDIDNMMTTMYQSSKATTSSCPSPEAFLQAYRGADNVIVMTITGTLSGSHNSARLAKNELLEENPNVNIHLIDSLSAGGEMDLLVLELERLINLGLSFEEVVKQITAYQQKTRLIFVLAKVDNLVKNGRLSKLVGKVIGLLNIRMVGKASNKGTLELLQKARGQKKAVSALIEEIQKEGYVGGKVYIAHAQNPKICEQISEKIKSLYPDAVIQTGRTSGLCSFYAEDGGLLMGYEI
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein SPs0389.
Protein: Y1808_MYCLE
Sequence: MTLPLLGPMSLSGFEHSWFFLFIFIVFGLAAFYVMMQVARQRRMLRFANMELLESVAPNRPVQWRHVPAILLMLALLLFTIAMAGPTNDVRIPRNRAVVMLVIDVSQSMRATDVEPNRMAAAQEAAKQFAGELTPGINLGLIAYAGTATVLVSPTTNRYATKNALDKLQFADRTATGEAIFTALQAIATVGAVIGGGEMPPPARIVLFSDGKETMPTNPDNPKGAYTAARTAKDQGVPISTISFGTVYGFVEINGQRQPVPVDDETMKKVAQLSGGNSYNAATLAELKAVYASLQQQIGYETIKGDASAGWLRLGVLVLALAALTALLINRRLPT
What are the official names of this protein?
UPF0353 protein ML1808.
What is the protein family that this protein belongs to?
Belongs to the UPF0353 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CN178_HUMAN
Sequence: MGREMKKTGTPRPFRIEDPNQQPTWHDQPEMGSHYFAQAGLELLGSSNPPASASQSAGITGVSHCARPGEHDLNHTVFQVKDSTFLRHLESDRPEFKSCLPPHFTEPSVSLSTSEGCEDAMG
What are the official names of this protein?
Uncharacterized protein C14orf178.
Protein: DAPB_STAAB
Sequence: MKILLIGYGAMNQRVARLAEEKGHEIVGVIEPTPRATTPYQQYQHIADVKDADVAIDFSNPNLLFPLLDEEFHLPLVVATTGEKEKLLNKLDELSQNMPVFFSANMSYGVHALTKILAAAVPLLDDFDIELTEAHHNKKVDAPSGTLEKLYDVIVSLKENVTPVYDRHELNEKRQPQDIGIHSIRGGTIVGEHEVLFAGTDETIQITHRAQSKDIFANGAIQAAERLVNKPNGFYTFDNL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_COXBN
Sequence: MLPVIAIVGRPNVGKSTLFNYLTKSRAALVADVPGVTRDRQYGETTIDSQRLLLVDTGGLVDTENKEVAPLAETQVEQAIDESDCILFLVDAKAGLVPADEIIAERLRKKGKKIFLAVNKADRARAAVVQSDFYKLGFGEPYVIAAASGRGVKDLMTQVLENLPEEKEVIEKEVGIKIAMIGRPNVGKSTLINRLLGEERVIVYDQPGTTRDSIYIPFARNDENYTLIDTAGIRRRAKIQDYVEKFSMIKSLQAMHAADVVIFLLDARQGVTEQDLRLLNRIVEAGVSLIIAVNKWDGLNIEERDNVRNAIDRRMPFVDFARRYFISALHGTGVGKLFRAIQESYQSIQQELTTGQLTRALEKAVAEHEPPLVKGRRIRLRYAHLGARHPLTIVVHGKQTKSLPQSYSRYLANYFRKTFNFIGVPVHIKLKTDPNPYEGQEER
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: LEU3_BUCUD
Sequence: MKKKYRIAVLPGDGIGPEVMREAYKILNILKNHFSLPLETREFNIGGSAIDQEGTALPKKTLLGCENSDAILFGSVGGKKWDDLPINQRPERASLLPLRKHFNLFANLRPAKLYSELKYLSPLRSDIIKNGFDILCIRELTGGLYFGKPTGRLKKNNIEYAFDTEIYYNYEITRIAHLAFQLAQTRNFKICSIDKSNVLNSSVLWREIVKKVSKNYPDVHLSHLYIDNATMQIIKDPNQFDILLCSNLFGDIISDECAIITGSIGMLPSASLNEKKFGLYEPAGGSAPDIEGKNIANPIAQILSVSMLVRYGMNLKTIADKIDQSVISVLKKGYRTADISNNNNYLKTNEMGDVIANTLISGE
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHDV_ECO57
Sequence: MKRLIPVALLTALLAGCAHDSPCVPVYDDQGRLVHTNTCMKGTTQDNWETAGAIAGGAAAVAGLTMGIIALSK
What are the official names of this protein?
Uncharacterized protein YhdV.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURD_BACTN
Sequence: MKRIVILGAGESGAGAAVLAKVKGFETFVSDMSAIKDKYKDLLDSHHIAWEEGHHTEELILNADEVIKSPGIPNDAPLILKLKAQGTPVISEIEFAGRYTDAKMICITGSNGKTTTTSLIYHIFKSADLNVGLAGNIGKSLALQVAEEHHDYYIIELSSFQLDNMYNFRANIAVLMNITPDHLDRYDHCMQNYIDAKFRITQNQTTDDAFIFWNDDPIIKQELAKHGLKAHLYPFAAVKEDGAIAYVEDHEVKITEPIAFNMEQEELALTGQHNLYNSLAAGISANLAGITKENIRKALSDFKGVEHRLEKVARVRGIDFINDSKATNVNSCWYALQSMTTKTVLILGGKDKGNDYTEIEDLVREKCSALVYLGLHNEKLHAFFDRFGLPVADVQTGMKDAVEAAYKLAKKGETVLLSPCCASFDLFKSYEDRGDQFKKYVREL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUTE_ECO8A
Sequence: MNEAVSPGALSTLFTDARTHNGWRETPVSDETLREIYALMKWGPTSANCSPARIVFIRTAEGKERLRPALSSGNLQKTLTAPVTAIVAWDSEFYERLPQLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIVACRALGLDTGPMSGFDRQHVDDAFFAGSTLKSNLLINIGYGDSSKLFARLPRLSFEEACGLL
What is the function of this protein?
May reduce toxic product malonic semialdehyde to 3-hydroxypropionic acid, which is excreted.
What are the official names of this protein?
Probable malonic semialdehyde reductase RutE.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family. HadB/RutE subfamily.
Protein: CA1F_CONRE
Sequence: DYCCRRPPCTLIC
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
What are the official names of this protein?
Alpha-conotoxin-like Reg1f.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYI_PECAS
Sequence: MSDYKTTLNLPETGFPMRGDLAKREPDMLKRWYEQDLYGIIRNAKKGKKTFILHDGPPYANGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQLIGKPGEKVSAAEFRAECRKYAAEQVAGQKADFIRLGVLGDWDRPYLTMDFKTEANIIRALGRIIENGHLHKGAKPVHWCADCGSALAEAEVEYYDKTSPSIDVTFNASDVAAVLAKFGVSRVDGPISLVIWTTTPWTLPANRAISLNAEFDYQLVQIDGQALILAADLVESVMKRVGVTQWIVLGDCKGADLELLRFKHPFLGFDVPAILGDHVTLDAGTGAVHTAGGHGPDDYVISQKYNLEIANPVGPNGCYLSGTYPELDGKFVFKANDLIVEILREKSMLLHVEKLQHSYPCCWRHKSPIIFRATPQWFVSMDQKGLRKQSLSEIKDVQWIPDWGQARIEAMVANRPDWCISRQRTWGVPMSLFVHKETEELHPRTAELIEAVAKRVEADGIQAWWDLDPADVLGADADNYVKVPDTLDVWFDSGSTHASVVDVRPEFGGHEADMYLEGSDQHRGWFMSSLMISTAIKGKAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMNKLGADILRLWIGSTDYSGEIAVSDEILKRSADAYRRIRNTARFLLANLNGFDPQKDSVKPEDMVVLDRWAVGCAKAAQDEILEAYESYDFHRVVQRLMQFCSIEMGSFYLDIIKDRQYTAKGDSVARRSCQTALYHISEALVRWMAPIMSFTADELWNYLPGERAQYVFTEEWYDGLFALDASETMNDAFWADVLKVRSEVNKVIEQARNDKRIGGSLEASVTLYADANLADKLNQLRQELHFALLTSKARVERYENAPDSAQATELTGLKIALSEAEGHKCPRCWHYETDIGSNADHPEVCGRCATNVGGNGEERKFV
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_SODGM
Sequence: MSHSASLYAEAQQLIPGGVNSPVRAFNGVGGTPLFIASADGARLTDADGNSYIDYVGSWGPMVLGHNHPAIRQAVLDAVQRGLSFGAPTEIEVKMARLLTELVPSIESVRMVNSGTEATMSTIRLARGYTGRDRVIKFEGCYHGHADGLLVKAGSGALTLGQPSSPGVPADYAKYTLTCSYNDLQSVREAFTLYPREIACVIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVMTGFRVELGGAQAYYDVKPDLTCLGKIIGGGMPVGAFGGRREVMAALAPTGPVYQAGTLSGNPVAIAAGYACLREVARPGVHQQLTQQTERLAQGLLAAAEAAGVPLVVNRVGGMFGLFFTESPTVTCFQDVQACDVDRFKRFFHLMLAAGVYLAPSAFEAGFMSLAHGDAEIRHTVEAAAQSFAQL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_BRUME
Sequence: MARNKIALIGSGMIGGTLAHLAGLKELGDVVLFDIAEGTPQGKGLDIAESSPVDGFDAKFTGANDYAAIEGADVVIVTAGVPRKPGMSRDDLLGINLKVMEQVGAGIKKYAPEAFVICITNPLDAMVWALQKFSGLPAHKVVGMAGVLDSARFRYFLSEEFNVSVEDVTAFVLGGHGDSMVPLARYSTVAGIPLSDLVKMGWTSQDKLDKIIQRTRDGGAEIVGLLKTGSAFYAPAASAIQMAESYLKDKKRVLPVAAQLSGQYGVKDMYVGVPTVIGANGVERIIEIDLDKDEKAQFDKSVASVAGLCEACIGIAPSLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: DEPS1_CAEEL
Sequence: MSERQSKYFDYQGIVISSTGQDNQDSETDLVYLIQAHGKAAPKNIMYGVSKCAFVPTNLERNFDNIEEAKNLERRSKIPLKFGEVILWNESDCDHDKRIILHIKREKPIYEASSSRNGLILKVGGVIQPTSTTSFWTPLCTVTMPETEATRAEPDVWLYAWIRFETTMKSGLDPFNMTATFESFDSCDPSDQARVCEAPWNAGSPDSKFGVWRPDPKPADSDDEIDIEPREGWHLPEDKWAEVIKMQLGLYVGERLLICKELSQFDFIIPLQKPFSRGTDKTLIYPAVGEYFHFSAIWSMQHNGFLIYELQPVPLLRQHVTSVNGNLLTRVVPASIRGLFVDKEGTLGLIDDPHHLLSFFEFHPAGYEFLKAMAEVRAVRTSENKSVRYRIVRTSGMSIFENWLRDTQFVVGPVKGIRINEDTVICAKHPNVYFKIPNNLKEGIPIGGGVQFVGKRQAGVDSEIMITECSPCPAFTCKNYSVSGDTRLFQVYLKPNCDHEQLAESDSMGFVDFRELETPCRGKFLAWVRESITVNDCRRAATIMEVCSTAICPPLIAMSANSSRATSARTTPAGSSIGSRSSIQSRASAATSVSSNRFVGPSSRRTPSGTPQSSTSSRV
What is the function of this protein?
Component of P-granules which is required for P-granule formation and integrity in adult germ cells (PubMed:18234720).  Promotes the accumulation of glh-1 mRNA and localization of pgl-1 to P-granules (PubMed:18234720).  Involved in RNA-mediated gene silencing (RNAi) in the germline (PubMed:18234720, PubMed:32843637).  In particular, it is required for piwi-interacting RNA (piRNA) gene silencing and positively regulates the formation of secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue (PubMed:32843637).  Its role in RNAi may also be through positively regulating the expression of the dsRNA-binding protein rde-4 (PubMed:18234720).  Plays a role in small RNA-directed transgenerational epigenetic inheritance (PubMed:27015309, PubMed:29769721).
What are the official names of this protein?
P-granule-associated protein deps-1, Defective P granules and sterile protein deps-1.
What are the subcellular locations of this protein?
Cytoplasmic granule. Cytoplasm, perinuclear region. Note=Localizes to P-granules in germ cells at all stages of development (PubMed:18234720). Co-localizes with prg-1 at peri-nuclear P-granules in the proliferative zone and transition zone, at pachytene, in oocytes and in embryos (PubMed:32843637). In the distal loop, a higher proportion of deps-1 than prg-1 dissociates from the perinuclear region (PubMed:32843637). In the adult germline, co-localizes with znfx-1 at P-granules and with pgl-1 at P-granules in the pachytene region (PubMed:32843637).
Protein: INO1_SESIN
Sequence: MFIESFKVESPNVKYTEGEIHSVYNYETTELVHESRNGTYQWIVKPKTVKYEFKTDTHVPKLGVMLVGWGGNNGSTLTGGVIANREGISWATKDKVQQANYFGSLTQASSIRVGSFNGEEIYAPFKSLLPMVNPDDVVFGGWDISNMNLADAMGRAKVLDIDLQKQLRPYMEHMVPLPGIYDPDFIAANQGSRANNVIKGTKKEQVQQIIKDMRDFKEQNKVDKVVVLWTANTERYSNVVVGLNDTAESLMASVERNEAEISPSTLYAIACVFENVPFINGSPQNTFVPGLIDLAIQRNSLIGGDDFKSGQTKMKSVLVDFLVGAGIKPTSIVSYNHLGNNDGMNLSAPQTFRSKEISKSNVVDDMVASNGILYEPGEHPDHIVVIKYVPYVGDSKRAMDEYTSEIFMGGKSTIVLHNTCEDSLLAAPIILDLVLLAELSTRIQLKAEGEGKFHSFHPVATILSYLTKAPLVPPGTPVVNALSKQRAMLENILRACVGLAPENNMILEYK
What is the function of this protein?
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner.
What are the official names of this protein?
Inositol-3-phosphate synthase, MIP synthase, Myo-inositol 1-phosphate synthase, IPS, MI-1-P synthase.
What is the protein family that this protein belongs to?
Belongs to the myo-inositol 1-phosphate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URM1_BOTFB
Sequence: MATDTLSIVVEFTGGLEMLFSDQRSHKLSVPKTDSKGAPVTVGWLVNYLCDEIMQDSRKDMFVLDDHVRPGILVLINDADWELEGEASYELQSNDNILFVSTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSC1_HEMSA
Sequence: MANVTGPQMAFYGSGAATFGYPEGMTVADFVPDRVKHMVLDHWYNYPPVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLIMLTTNFPPFCYNCFSGGRWMFSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNGPKLTQGKATFMCGLAWVISVGWSLPPFFGWGSYTLEGILDSCSYDYFTRDMNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQAKKMNVTNLRSNEAETQRAEIRIAKTALVNVSLWFICWTPYAAITIQGLLGNAEGITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAITQHLPWFCVHEKDPNDVEENQSSNTQTQEKS
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.  This opsin produces visual pigments with maximal absorption in the blue-green region of the spectrum.
What are the official names of this protein?
Compound eye opsin BCRH1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ERO1B_HUMAN
Sequence: MSQGVRRAGAGQGVAAAVQLLVTLSFLRSVVEAQVTGVLDDCLCDIDSIDNFNTYKIFPKIKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGHSNKYLKMANNTKELEDCEQANKLGAINSTLSNQSKEAFIDWARYDDSRDHFCELDDERSPAAQYVDLLLNPERYTGYKGTSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDDGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFKHRFDPVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNAEEDADTKTLLLNIFQDTKSFPMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEKEIQKLPENSPSKGFQLTRQEIVALLNAFGRLSTSIRDLQNFKVLLQHSR
What is the function of this protein?
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum.  Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation.  Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%).  Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell.  May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
What are the official names of this protein?
ERO1-like protein beta, ERO1-L-beta, Endoplasmic reticulum oxidoreductase beta, Endoplasmic reticulum oxidoreductin-1-like protein B, Oxidoreductin-1-L-beta.
What is the protein family that this protein belongs to?
Belongs to the EROs family.
Protein: CEMA_ATRBE
Sequence: MAKKKAFTPLFYLASIVFLPWWISFSVNKCLESWVTNWWNTGQSEIFLNNIQEKSLLEKFIELEELLLLDEMIKEYSETHLEEFGIGIHKETIQLIKIQNENRIHTILHFSTNIICFIILSGYSILGNEKLVILNSWAQEFLYNLSDTVKAFSILLLTDLCIGFHSPHGWELMIGSIYKDFGFVHNDQIISGLVSTFPVILDTIFKYWIFRYLNRLSPSLVVIYHSMND
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: PUR4_ARATH
Sequence: MNTSQATRAALFLNGSNRQAMLLQRSSMSQLWGSVRMRTSRLSLNRTKAVSLRCSAQPNKPKAAVSTGSFVTADELPSLVEKPAAEVIHFYRVPLIQESANAELLKAVQTKISNQIVSLTTEQSFNIGLESKLKDEKLSVLKWILQETYEPENLGTDSFLERKKQEGLHAVIVEVGPRLSFTTAWSTNAVSICRACGLDEVTRLERSRRYLLFSKEPLLENQIKEFAAMVHDRMTECVYTQKLVSFETNVVPEEVKYVPVMEKGRKALEEINQEMGLAFDEQDLQYYTRLFREDIKRDPTNVELFDIAQSNSEHSRHWFFAGNMVIDGKPMDKSLMQIVKSTWEANRNNSVIGFKDNSSAIRGFLVNQLRPLLPGSVCLLDVSARDLDILFTAETHNFPCAVAPYPGAETGAGGRIRDTHATGRGSFVVASTSGYCVGNLNMEGSYAPWEDSSFQYPSNLASPLQILIDASNGASDYGNKFGEPMIQGYTRTFGMRLPSGDRREWLKPIMFSAGIGQIDHTHITKGEPEVGMLVVKIGGPAYRIGMGGGAASSMVSGQNDAELDFNAVQRGDAEMSQKLYRVVRACIEMGEKNPIISIHDQGAGGNCNVVKEIIYPQGAEIDIRAVVVGDHTMSVLEIWGAEYQEQDAILVKAESREILQSICKRERLSMAVIGTINGGGRCTLIDSTAAAKCSKEGLPPPPPAVDLELEKVLGDMPKKTFKFNRIAYAREPLDIAPGITLMDALKRVLRLPSVSSKRFLTTKVDRCVTGLVAQQQTVGPLQITLADVAVIAQTFTDLTGGACAIGEQPIKGLLDPKAMARLAVGEALTNLVWAKVTALSDVKASGNWMYAAKLEGEGSAMYDAAIALSEAMIELGIAIDGGKDSLSMAAHADGEVVKAPGNLVISAYVTCPDITKTVTPDLKLGGDDGILLHVDLAKGKRRLGGSALAQVFGQIGNDCPDLDDVPYLKNVFDGVQALIAENLVSAGHDISDGGLVVTALEMAFAGNKGINLDLASNGISLFETLFSEELGLVLEISKTNLDAVMEKLRAFDVTAEIIGNVTDSPLIEVKVDGITHLSEKTSFLRDMWEDTSFQLEKLQRLASCVEMEKEGLKFRHEPNWKLSFIPSSTNNNYMSQDVKPKVAVIREEGSNGDREMSAAFYAAGFEPWDVTVSDLLAGDITLDQFRGIVFVGGFSYADVLDSAKGWAASIRFNEPVLSQFQEFYKRPDTFSLGICNGCQLMALLGWVPGPQVGGSLDTSQPRFVHNESGRFECRFTSVTIKDSPSIMLKGMEGSTLGVWAAHGEGRAYFPDEGVLDHMLHSDLAPLRYCDDDGNVTEAYPFNLNGSPLGIAAICSPDGRHLAMMPHPERCFLMWQFPWYPTSWDVEKAGPSPWLKMFQNARDWLESC
What is the function of this protein?
Essential to the male gametophyte development.  Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
What are the official names of this protein?
Probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT, Formylglycinamide ribotide amidotransferase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Mitochondrion.