PharMolix/UniProtQA huggingface dataset:
Protein: SSB1_SCHPO
Sequence: MSEVYEGAIGIDLGTTYSCVAVWETANVEIIPNDQGARTTPSFVAFTETERLVGDAAKNQAAMNPRNTVFDAKRLIGRRYEDPETQKDIKHWPFKVIDNNGIPTIEVNYLGEKKQFTAQEISAMVLTKMKEISEAKLNKRVEKAVITVPAYFSDSQRAATKDAGAIAGLNVLRIINEPTAAAIAYGLDAKSDKPKNVLIFDLGGGTFDVSLLKIQGGVFEVLATAGDTHLGGEDFDNALVEHFIQEFKRKQKIDISDDPRALRRLRSACERAKRALSSVTQTTVEVDSLSNGIDFSSSITRARFEDINATTFKATIDPVAKVLKDSKVPKADVHDIVLVGGSTRIPKVQRLVSDFFDGRALNKSINPDEAVAYGAAVQAAVLTNKADSDKTQDLLLLDVVPLSLGVAMEGNVFGVVCPRNTPIPTIKKRTFTTVADNQTTVTFPVYQGERVNCAENEPLGEFQLTGIPPMPRGQAELEATFELDANGILKVTAVEKTTGRSAHIEITNSVGHLSSTKIQEMIENADKFKQQDKDFAKKLEAKSQLESYISNIETTISEPNVMMKLKRGDKSKIEAQLAECMSQLELEDTNTDALRKAELRLKRTVQKAFASLR
What is the function of this protein?
Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol.  Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized.  The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD.  The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state).  During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain.  Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state.  Hsp110 chaperone pss1 and fes1 act as nucleotide exchange factors that cause substrate release.
What are the official names of this protein?
Ribosome-associated molecular chaperone sks2, Heat shock cognate protein hsc1, Hsp70 chaperone Ssb, Suppressor of K-252a sensitivity protein 2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with translating ribosomes.
Protein: TRUA_ACTP7
Sequence: MKIALGIEYDGSRYFGWQRQDEVESVQQKLEEALSIVANAPIEVFCAGRTDSGVHGTGQVVHFETQAIRPLQSWCFGTNANLPDDIAVKWAVEVSEDFHARFSATARRYRYIIFNNKLRSAILPKGVSHYHYELDHQKMHEAGQFLLGENDFSSFRAAKCQSHTPWRNVHHLNVSRLGNYIVVDIQANAFVHHMVRNIVGSLIEVGQGRQPVEWIQWLLAQRDRTLAAPTAKAEGLYLVDVHYPERFGIPKTALGPLFLANN
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: PKS3_RUBID
Sequence: MVTVDEVRKAQRAEGPATILAIGTATPPNCVDQSTYPDYYFRITKSEHRTELKEKFQRMCDKSRIKKRYMYLTEEILKENPSMCEYMAPSLDARQDMVVVEIPKLGKEAATKAIKEWGQLKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLAVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIVGSDPLPDIERPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPLDITDWNSLFWIAHPGGPAILDQVEAKLGLKPEKLEATRNILSEYGNMSSACVLFILDEVRRKSVANGHKTTGEGLEWGVLFGFGPGLTVETVVLHSVAAST
What is the function of this protein?
Polyketide synthase producing p-coumaryltriacetic acid lactone (CTAL) and slightly naringenin chalcone.  Can use p-coumaryl-CoA as substrate.
What are the official names of this protein?
Polyketide synthase 3, RiPKS3, Naringenin-chalcone synthase PKS3.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: CLPP_CYCTA
Sequence: MPIGVPKVPFRIPGEEDNRLYRERLLFPGQQVDDEIANQLIGIMMYLNGEDENKDIYPYINSPGGAVIPGISIYDAMQFVVPDVHTICMGLAASMGSSVLTGGEITKRIALPHARVMIHQPASSYYDGQAGECIMEAEEVLKLRDSITNVYVQRTGKPLWVISGDMERDVFMSATEAQAYGIVDLVAVENTEDLL
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: ANGP1_RAT
Sequence: MTVFLSFAFFAAILTHIGCSNQRRSPENGGRRYNRIQHGQCAYTFILPEHDGNCRESATEQYNTNALQRDAPHVETDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYELEKQLLQQTNEILKIQEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTFIIQELEKQLSRATSNNSVLQKQQLELMDTVHNLVSLCTKEVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYFNNMPEPKKVFCNMDVNEGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNQKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
What is the function of this protein?
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation.  Implicated in endothelial developmental processes later and distinct from that of VEGF.  Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.  Mediates blood vessel maturation/stability.  It may play an important role in the heart early development.
What are the official names of this protein?
Angiopoietin-1, ANG-1.
What are the subcellular locations of this protein?
Secreted.
Protein: MANBA_HUMAN
Sequence: MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQDSYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETDNMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNFVRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFDVVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTGYNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPADSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACALYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKDYVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDCWNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAGLHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSVRVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHELLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFSDNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY
What is the function of this protein?
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
What are the official names of this protein?
Beta-mannosidase, Lysosomal beta A mannosidase, Mannanase, Mannase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: RNP4_METMA
Sequence: MPRAARKQQKNLIQNIAVQRMWRLFERAKVELPENPERSRHYVQLIRNISMRNRISIPREIKSRICKHCYSFLTPGYNARYRLNEGFVVITCEHCGKEMRYPYKKLK
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 4, RNase P component 4, Rpp21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFR1_LACJO
Sequence: MKLFAIVGSNADHSYNRDLLNFIKKHFTDRYDIELGEVKDLPMFKEGVKEPAAVASFAKKVADADAVLISTPEQQHSVPSSLKSALEWLSSAEHPFKDKPVVIVGTSVLPQGSARGQSHLKLVLSSPGFGAKVFNGDEFMMGTAPEQFDENGNLPAGTVKFLDHFFDEFDSFYAEVSK
What is the function of this protein?
Component of an enzyme that catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH; the reduced flavins produced by this reaction likely spontaneously react with oxygen, yielding hydrogen peroxide.  Is responsible for the major H(2)O(2) production in L. johnsonii in the presence of oxygen.  Cannot use NADPH instead of NADH as the electron donor.
What are the official names of this protein?
NADH-dependent flavin reductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the NADH-dependent flavin reductase family.
Protein: ACCD_HALH5
Sequence: MLKDFFSKKKRYATIPSERAKHDIPEGIMTKCPSCRTIMYTKELKKNLYVCDSCGFHHRMNAFDRIESLLDPGTFVELDKGMTTEDPLSFPTYREKVEADRKKTNLNEAIVTGEGTMNGFPLVIGVMDARFRMGSMGSVVGEKITRAIERAIENKQPFLLFSASGGARMQEGVLSLMQMAKTSAALERLDRVGGLFISVMTHPTTGGVSASFASLGDYNFAEPGALIGFAGRRIIEQTIREELPNDFQTAEFLLKHGQLDRVIPRSEMKDTLTKILDIHHVS
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
Protein: HAS1_ASPFU
Sequence: MSGPVDTAKSITKKRKRKHGGGARAATETDDAITRPAIENGAVNDSPEKEEDTKKSEKNGKDKSAKKRKVSHASSDEGDESQEEQGAPAQADGDSDDNKDDGNDQSEAENGDNGDKKDTESTDLPSAGTLSLPTVEGEPQKFTELGLSEKTLKAINDMGFETMTEIQRRTIPPLLAGRDVLGAAKTGSGKTLSFLIPAVEMLSALRFKPRNGTGVIVVSPTRELALQIFGVARELCQYHSQTYGIVIGGANRRAEAEKLMKGVNLLIATPGRLLDHLQNTQGFVFKNLKTLVIDEADRILEVGFEDEMRQIVKILPSEERQTMLFSATQTTKVEDLARISLRPGPLYINVDHRKEHSTVEGLEQGYVICEADKRFLLLFSFLKRNLKKKIIVFFSSCNCVKYHAELLNYIDLPVLELHGKQKQQKRTNTFFEFCNAKQGTLICTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARGTNAKGRSLMFLQPSEVGFLKHLKEARVPVVEFEFPANKIVNVQSQLEKLIGQNYYLNKSAKEGYRSYLQAYASHSLRSVFDVHKLDLVKVAKGFGFSTPPRIDIQLGASLSRDKKQQQQGRRSYGSQPHSKGLKFKRKHDD
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase has1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: QUEF_ECOHS
Sequence: MSSYANHQALAGLTLGKSTDYRDTYDASLLQGVPRSLNRDPLGLKADNLPFHGTDIWTLYELSWLNAKGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFNNWDEVRQTLERDLSTCAQGKISVALYRLDELEGQPIGHFNGTCIDDQDITIDNYEFTTDYLENATCGEKVVEETLVSHLLKSNCLITHQPDWGSIQIQYRGRQIDREKLLRYLVSFRHHNEFHEQCVERIFNDLLRFCQPEKLSVYARYTRRGGLDINPWRSNSDFVPSTTRLVRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4E_CANGA
Sequence: MSVDEVTKKFEETVSVDGPKTVLSDAKDFEVKHPLNTKWTLWYTKPAVDKSESWSDLLRPVTSFQSVEEFWAIVQNIPEPHELPLKSDYHVFRNDIRPEWEDSANAKGGKWSFQVRGRGAEIDELWLRTLLAVIGETIDEEDSQINGVVLNVRKGGNRFALWTKSCDKEPLSNIGARFKQVLKLADEDTLEFFPHSTANDRHSQPTITL
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
What are the official names of this protein?
Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
Protein: RAPA_ECO24
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDLINYLASPDQTEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQIMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: KTHY_HELPJ
Sequence: MYVVLEGVDGAGKSTQVGLLKDRFKNALFTKEPGGTRMGESLRRIALNENISELARAFLFLSDRAEHIESVIKPALKEKKLIISDRSLISGMAYSQFSSLELNLLATQSVLPEKIILLLINKENLKQRLSLKSLDKIENQGIEKLLTIQQKLKTHAYALQEKFGCEVLELDAQKSAKNLHEKIATFIECVV
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: ETC3_ARATH
Sequence: MDNHRRTKQPKTNSIVTSSSEEVSSLEWEVVNMSQEEEDLVSRMHKLVGDRWELIAGRIPGRTAGEIERFWVMKN
What is the function of this protein?
MYB-type transcription factor involved in epidermal cell fate specification.  Acts as a negative regulator of trichome development, including endoreplication, by mediating lateral inhibition.  Promotes the formation of hair developing cells in H position in root epidermis, probably by inhibiting non-hair cell formation.  May have pleiotropic effects on flowering development and epidermal cell size through the regulation of endoreduplication.
What are the official names of this protein?
MYB-like transcription factor ETC3, Protein CAPRICE-like MYB3, Protein ENHANCER OF TRY AND CPC 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPG_PROMT
Sequence: MANLKDIRDRIVSVKNTRKITEAMRLVAAAKVRRAQDQVLRSRPFADRLARVLENIQSRMQFEAADSPLLNKREVKTITLLAVTGDRGLCGGYNANIIKRTEKRYAELKGQGYSPDLVLIGKKAIGYFENRSSLYKIRATFKELEQVPTSEDAASITSEVLAEFLSESTDRVEVIFTKFVSLVSCNPTIQTLLPLDPQGIADSEDEIFRLTTKDSQLIIEKDAAPSNEEPKLPSDIVFEQSPDQLLNALLPLYLQNQLLRALQESAASELASRMTAMNNASDNAKELAKNLTIDYNKARQAAITQEILEVVGGASA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: Y2594_LACPL
Sequence: MIFLIAIIPALCWGINPLLVGKINGHSENEMFGMGIGDGLIALIFWLFSQPTVTISGVTFGLAMISGAAWAIGQLGQYISYRLLGVSKTMPISTALQLVGTSLIGVLMFGEWGSSNQKILGLLAIMLIVAGSALSAGTSDGRKKGFSCYLPLLMTTIGYWIYSCIPKLVKVDALQLFLPQMLGILIVAVGWAIYHQPTVYRDKQSWQNTLPGILYGIAAFMYILSARSIGVTNAYIIGQLSVVISTLSGLFFLHERTGQQSIVSVATGLLFIFMGCVTTALI
What are the official names of this protein?
Putative sugar uptake protein lp_2594.
What is the protein family that this protein belongs to?
Belongs to the GRP transporter (TC 2.A.7.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FEN1_VANPO
Sequence: MGIKGLNAIISEHVPSAVRKSDIKTFFGRKVAIDASMSLYQFLIAVRQQDGGQLTNEAGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPVLKSHELSKRTARREETEKKLQEATDQAEKMKQERRLVKVSKEHNDEAKQLLELMGIPYITAPCEAESQCAELAKCGKVYAAASEDMDTLCYRTPYLLRHLTFSEAKKEPIHEIDTELVLKGLDLTLEQFVDLGIMLGCDYCDSIKGVGPVTALKLIKEYGSLEKIIEYIESDSSNSKWKIPNDWPYKDARELFLKPDVINGNEVELKWQPPNEKGLIDFLCGEKKFSEERVKSGIERLKKGLKSGVQGRLDGFFQVVPKTKEQLAKAAAKAKAAKKSGKVTKKRR
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: VP2_FCVF4
Sequence: MNSILGLIDTVTNTVGKGQQIELDKAALGQQRELALQRMSLDRQALNNQVEQFNKLLEQRVHGPIQSVRLARAAGFRVDPYSYTNQNFYDDQLNAIRLSYRNLFKN
What is the function of this protein?
Minor structural protein present in one or two copies per virion.  Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).
What are the official names of this protein?
Protein VP2, Minor capsid protein.
What is the protein family that this protein belongs to?
Belongs to the vesivirus VP2 protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: IL17L_CRAGI
Sequence: MGNFFLFAMTLVVCSVIVLLTGVADSAVICSEPTNLAEQYSQYMANATVSNMLEYLESSTAGGVASDEEEQLIYGNRICPSSIKAITTDPKSSVFERTTCPYFLVASHLSTRYPKIITEARCKCSGCVPLEENGHSDLTRCEPVYRPVRVLSRTGNCVNGVYQYAAAVHMKQEGCTCVRKTEALSGSGSGSNGSDDPIPM
What are the official names of this protein?
Interleukin 17-like protein, CgIL-17.
What is the protein family that this protein belongs to?
Belongs to the IL-17 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NFM_MOUSE
Sequence: MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSMVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEETLTAIAEELAASAKEEKEEAEEKEEEPEAEKSPVKSPEAKEEEEEGEKEEEEEGQEEEEEEDEGVKSDQAEEGGSEKEGSSEKDEGEQEEEEGETEAEGEGEEAEAKEEKKIEGKVEEVAVKEEIKVEKPEKAKSPMPKSPVEEVKPKPEAKAGKGEQKEEEKVEEEKKEVTKESPKEEKVEKKEEKPKDVADKKKAESPVKEKAVEEVITISKSVKVSLEKDTKEEKPQPQEKVKEKAEEEGGSEEEGSDRSPQESKKEDIAINGEVEGKEEEEQETQEKGSGREEEKGVVTNGLDVSPAEEKKGEDSSDDKVVVTKKVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQGD
What is the function of this protein?
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber.  May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690).
What are the official names of this protein?
Neurofilament medium polypeptide, NF-M, 160 kDa neurofilament protein, Neurofilament 3, Neurofilament triplet M protein.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon.
Protein: PTC_DROME
Sequence: MDRDSLPRVPDTHGDVVDEKLFSDLYIRTSWVDAQVALDQIDKGKARGSRTAIYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLRDMCNMPSTPSFEGIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIPGSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYDLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVGPEAELVPLEHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRGSCQKSHHHHHKDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQGPPTTPPPPFPTAYPPELQSIVVQPEVTVETTHSDSNTTKVTATANIKVELAMPGRAVRSYNFTS
What is the function of this protein?
Segmentation polarity protein.  Acts as a receptor for the hedgehog protein (HH).  Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself.  Participates in cell interactions that establish pattern within the segment and the imaginal disks during development.  In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).
What are the official names of this protein?
Protein patched, Hedgehog receptor.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS17_CHRVO
Sequence: MSETKVVRTLTGVVVSDKMDKTVTVLVERKVKHPIYGKIIRRSKKFHAHDENNEFKAGDLVVISESRPLSKTKSWVVTGLVEKSRQV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: AKH_PRAMA
Sequence: QVNFSPGW
What is the function of this protein?
This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
What are the official names of this protein?
Adipokinetic hormone, AKH.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.