PharMolix/UniProtQA huggingface dataset:
Protein: PURA_BRUMA
Sequence: MLKEQPKGTVTVLLGAQWGDEGKGKIVDYLIAKDKVQVVARCQGGNNAGHTVVANGRKYDFHIIPSGIIAEKCFNIIGNGTVVNLDSFFEELDHNKITNIPGWEKRILISDRAHLICDIHMLVDGHSEDRLNINKIGTTKKGIGPTYSSKCFRNGLRVGDLVYDFDGFTLKFRELVKYYQKQYPDLEIDVDLELIKFKKHANKLNELALVADTVITLDELRSSGKTVLVEGANGTMLDIDFGTYPFVTSSNATVGGAITGLGLPPMSIKRVIGVTKAYSTRVGSGPFPTELKNDIGDKLQRIGHEVGVTTGRKRRCGWIDLVLLKRAHLINGFTDIALTKLDVLDTFDVIKAGVAYRLDKELLKSPPSQASDWEKVEVEYRTFKGWNTPILAMRSFNELPENCRIFIEFIEQYVGVPVKWIGVGEEREALILREP
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_CLOBJ
Sequence: MRNTVSTFQELKNKGEKITMLTAYDYSMAKLIDSSGINGILVGDSLGMVCLGYENTLSVTMEDMLHHTKAVVRGTSNALVVGDMPFMSYQTSIYDAVYNAGRFIKEAGAHAVKLEGGATVAEEIKAIVKAQIPVMGHIGLTPQSVNMFGGFKVQGKNEKVAKKLIEDAKILEEAGAFSIVLECIPEKLSKIISESISIPTIGIGAGKYCDGQILVYQDMLSMFSDFKPKFVKSFGNIGESIKDGVSQYIKEVKEAKFPEEKHAFKIDDDVINKLY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_PSEA8
Sequence: MKRLWQHCHAATLKGGKYSIVEDAALVTDGPLIHWIGPRAELPPGDYAERIDLGGAWLTPGLIDCHTHAVFGGNRSGEFEQRLEGVSYAVIAAAGGGIASTVRATREASEEELLASARKRLEPLLRDGVTALEIKSGYGLDLASERKMLRVIRRLGERLPATVRSTCLAAHALPPEYAGRADDYIEHICSTMLPALAGEGLVDAVDAFCEHLAFSPAQVERVFIAARELGLPVKLHAEQLSSLHGSSLAARYRALSADHLEYMTEDDARAMGEAGTVAVLLPGAFYLLRETQLPPIDALRRHGVAMAIASDLNPGTSPALSLRLMLNMACTLFRLTPEETLAGVTLHAARALGLEASHGSLEVGKLADFVAWDIERPAELAYWLGGDLPKRVIRHAEEVYRG
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODM2_STAAN
Sequence: MAFKLPNLPYAYDALEPYIDQRTMEFHHDKHHNTYVTKLNATVEGTELEHQSLADMIANLDKVPEAMRMSVRNNGGGHFNHSLFWEILSPNSEEKGGVIDDIKAQWGTLDEFKNEFANKATTLFGSGWTWLVVNDGKLEIVTTPNQDNPLTEGKTPILLFDVWEHAYYLKYQNKRPDYMTAFWNIVNWKKVDELYQAAK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.
What are the official names of this protein?
Superoxide dismutase [Mn/Fe] 2.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: VATA_METAC
Sequence: MEVKGEIYRVAGPVVTAIGLDAKMYDLCKVGNEGLMGEVIQIVGGKTIIQVYEETGGVKPGEPCVTTGMSLAVELGPGLLSSIYDGVQRPLHVLLEKTGGFIQRGVTADGLDHEKLWEFKPVAKKGDFVKGGEVLGVVQETVNLEHKVMMPPDKSGTVADIKSGNFTVLETVCTLTDGTELQMMHRWPVRRPRPVKRKLTPEKPLVTGQRILDGLFPVAKGGTAAIPGPFGSGKTVTQQQLSKWSDTEIVVYVGCGERGNEMADVLWDFPELEDPQTGRPLMERTILVANTSNMPVAAREASVYTGMTLAEYFRDMGYNVSLMADSTSRWAEAMREISSRLEEMPGEEGYPAYLSARLAEFYERAGVAETLCGEKGSITAIGAVSPPGGDFSEPVTQNTLRIVKVFWALDAKLSQRRHFPAINWLNSYSLYKEDLNDWFTENVAPDYVAMREKAMDMLQTESELQEIVQLVGSDALPEEQQLLLEITRMIREIYLQQNAFHPIDTYSPFAKQYKIMQAIMKYGDAAMDALKSGVPASEIIKMESKDELPKVKFEEDFDGSLSAVLAKMDKEFAALGGR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: CLSA_YERPS
Sequence: MTTFYTVISWLSVFGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSFGELHLGKRRAERAKAMWPSTARWLSELKECQHIFANSNSEVATPLFQLCERRQGINGVKGNQLQLLTTTDDTLKALVRDIELARHNIEMVFYIWQPGGLVDQVAESLMAAARRGVHCRLLLDSAGSKQFFRSPYPAMMRNAGIEVVEALKVNVFRMFLRRMDLRQHRKIVLIDNYVAYTGSMNMVDPRFFKQDAGVGQWIDMMARMEGPVATTLGIVYACDWEIETGKRILPPPPDANIMPFEEETGHTIQVIASGPGFPEEMIHQALLTAVYAAREQLIMTTPYFVPSDDLLHAICTAAQRGVDVSIIVPRENDSMMVRWASRAFFTELLNAGVKIYQFEGGLLHSKSVLVDGQLSLVGTVNLDMRSLWLNFEITLVIDDDGFGADLAQVQDDYIARSALLDGERWNKRPLWHRVTERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPB_PARD8
Sequence: MESFRYHDLGRIAYADALEYQTAAFEVLLDAKATGKKEDNQLFFCEHLPVLTIGKSGKDSNLLIPEETLRERGVSFYHINRGGDITYHGPGQITGYPVFDLEYWNLGLKQYIHMLEETIIRFLSLYDLKGERLEGATGVWLDPEVPGRARKICAIGVKSSRFVTMHGFALNINTDLSYFSLINPCGFTDKGVTSLAMELGVPQDFELAKSQLRSIFMEIFA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR8_SYNY3
Sequence: MIERYTLPEMGKIWTDTYKLQTWLDVEIAVCEAQAELGYIPQAAVDEIKAKAKFDPQRVLEIEAEVRHDVIAFLTNVNEYVGDAGRYIHLGLTSSDVLDTALALQLVASLDLILEQLEKLIQAIRYQAQQHRYTVMVGRSHGIHAEPITFGFKLAGWLAEVLRNRDRLVRVAQSIAVGKISGAVGTYANIDPKVEAIACQKLGLEPDTASTQVISRDRHAEYVQQLALLAASLERFAVEIRNLQRTDVLEVEEYFSKGQKGSSAMPHKRNPIRSERLTGMARLVRGHAVAALENVALWHERDISHSSVERVAFPDCCILTHFMLKETTDLVKNLLVYPENMKRNMNVYGGVIFSQKVLLALVEKGMNREDAYRVVQGSAHQAWNTEGGNFEELVRADAQVTALLSAEEIDQCFDPQQHLTNLAEIYSRLDI
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: MTNA_CAEEL
Sequence: MTSKINKIVNGPIPDSFLFDESKRLDSLKFDGTNLEVLDQLLLPHEFKYIPVEGVSDAFAVIKSMQVRGAPLIAVVGSLGLLLEIQKASELDSESIIQKINFLISSRPTAVDLRNSLNGLKPILESQDYSDVVKLEKCRSYLLNVYTDEKLQNRILVWNAYQELLSAFPDKEKLTVMTICNTGSLATISWGTALGVIRALHSENRLKLVYVLETRPYNQGIRLTSIELLHGEVPFKLITDSMAAWAMKNHQVDCVLTGADNVARNGDTANKIGTYMLAVLCKHHNINFYPVVPFTTINKNIATGEEIKIEERPSAEMLRVNGVLIGNSECPVWNPAFDVTPAHLITKILTDFGNWPPEMLEQQIPK
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RSMG_CAMC5
Sequence: MIEIPSDFSEQTAKFTQILAKFNRVHSLTNYKNFDEQISDSISPLKWLKFYPETAIDVGSGAGFPAIFLAMILKDCRWWLFEPNAKKSSFLSYVKAELNLKNVSVKSCKIEACEPFVAQLITSRALMKTKELLKICRGFYDNETQILLYKGSSVEGELDGLDAQIYGVKNRNYVFLNVKRDWKENE
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_BURL3
Sequence: MKLDLKILDARMRDYLPAYATTGSAGLDLRACLDAPVTLQPGETTLVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISTWNRGQTEFVLNPFERLAQLVIVPVVQAQFNIVDDFAESDRGDGGFGSTGRH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: PSTB_BURL3
Sequence: MNMAESHLNPVERTAAPAGTQEAAHGRPLEPLNAKIEVNNLNFFYNKFHALKNINLSIPEGKVTAFIGPSGCGKSTLLRTFNKMFALYPEQRAEGEIMMDGENLLTTKRDISLLRARIGMVFQKPTPFPMSIYDNIAFGVKMFEKLTRSEMDDRVEWALTKAALWNEVKDKLNQSGYGLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELIAELKSDYTVVIVTHNMQQAARCSDFTAYMYLGELIEFGETEKIFIKPVRKETEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FNR_SALMS
Sequence: MIPEKRIIRRIQSGGCAIHCQDCSISQLCIPFTLNEHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGSGHHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQMMRLMSGEIKGDQDMILLLSKKNAEERLAAFIYNLSRRFAQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGMLAVKGKYITIENSDALAALAGHTRNVA
What is the function of this protein?
Global transcription factor that controls the expression of over 100 target genes in response to anoxia.  It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism.  When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity).
What are the official names of this protein?
Fumarate and nitrate reduction regulatory protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK33_OLIPU
Sequence: MAKGKDVRVTIILECTSCVRNDIKKESSGISRYITQKNRHNTPSRLELRKFCPYCYKHTIHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y644_MYCPN
Sequence: MNKKRLLFRTPLDALFLLFGTALSACSSTATNVISSLSSAQKYFDAHKSELIKKNVINLLKEGYSTDSKATVNSLFAGWKYTLMDQKILERNLDASRFTKAFGTNKGKDDVIPSISEKGLFLDETYSGVSQQIAKVLGVQSQKVTGFSYSWSSTTNFKVVISFMMQGIVGSGEESNSLIKSFLSSGNNGNVTENDFNNGNANFDGTFIFTFTPPTDGRRFAFSNFDPITGTINFPANLQIDASTTHEKLNILMQNNEHVKKIKSRSFTGKSFDLLPFYFYALL
What are the official names of this protein?
Uncharacterized lipoprotein MG439 homolog 3.
What is the protein family that this protein belongs to?
Belongs to the MG439/MG440 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: DNLJ_RHILO
Sequence: MAEKPVDSLSESEAEAELKRLAEEIAGHDRRYHAEDAPTITDAEYDALRRRNLAIEERFPGLVREDSPSRRVGAPPAEGFAKVRHAVPMLSLAKAYTDEDVTDFIERGRRFFDRDKDLDIAFTAEPKIDGLSASLRYENGVFVQGATRGDGAVGEDITANLRTIADIPAKLKGSGWPDVIEIRGEVYMTYAEFEALKARSAAAGGQDYVNPRNTAAGSLRQKDASVTASRNLKFFAYAWGFTTADPAPTQYESVQKFADWGFKISPLMVRAKSVEELVAQYHLIEEQRSSLGYDIDGVVYKVDQLELQRRWGFVTGEPRWAVAHKFPAEQAMTTVQKIDIQVGRTGTLAPVARLAPVTVGGVVVENVTLHNEDYIKGFDSNGLPIRDGIDVRIGDTVVIQRAGDVIPQIVSVVIDKRPADAVPYEFPHTCPVCGSPATREINEKTGKEDSRRRCTGELICAAQAVERLRHFVSRGALDIEGLGAENIDTFFNAGLIKTAADIFTLRDRRPAVTKALAERREEQARQREAASGKTRKNVRSVEDRNYEGLDKLFAAIDSRREPELDRFIFALGIRHIGETTAAVLAKTFSTIEELIRVGKETAAAEDPHTVFPSVNGIGDTVIDALCDFFGNERNDDVLDKLLEQVKPKPYIVTVSADSEVAGKTIVFTGTLEKMTRSEAKAMAERLGAKVAGSVSAKTDLLVAGPGAGSKLKLASELGVEVIDEDTWLQRVGKA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: Y1595_HISS2
Sequence: MEIIIISGRSGAGKSVALRALEDIGYYCVDNLTMDLVPQLVDMLENKQHLVAISLDIRNLPQEPETLDHILNLLQEKYPVKIIFLDTDRNTLIRRYSDSRRLHPLSVQNLSLEAAIAAEKEHLEPLVQHANVIIDTTPLSPHELAERLREFLRGNTEKELQIIVESFGFKYGIPLDADYVFDVRFLPNPHWNQELRPMTGLEKPVIEFMQKHIEVDNFIYQTRNYIENWLPMLEKNNRSYLTIAIGCTGGKHRSVYIAQQIGEYFRAKGKKVQIQHKSLEKHTQNK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein HSM_1595.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: END4_STAAR
Sequence: MLLGSHVSMSGKKMLEGSAIEAHEYGETTFMIYTGAPQNTRRKSIEDLNITKGHEVMEKYGLSNIVVHAPYIINIANTTKPETFNLGVDFLQQEIERTQAIGAKDIVLHPGAHVGAGVDAGINKIIEGLNEVLTNDNNVRIALETMAGKGTEIGRSFEELARIIDGVHNNERLSVCFDTCHTHDAGYNVKEDFDGVLNEFDKIIGVDRIKVVHVNDSKNDRGAQKDRHENIGFGYIGFDALNYIVHHDSFKDIPKILETPYVGEDKKNKKPPYKLEIEMLKQQHFDPELKNKVMQQ
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RS4_BRASB
Sequence: MTKRSEAKYKIDRRMGQNIWGRPKSPVNRREYGPGQHGQRRKGKLSDFGVQLRAKQKLKGYYANISERQFHGIYVEAGRLKGDTGENLIGILERRLDTVVFRAKFVSTMFAARQFINHGHIKVNGRKVNIASYQVKPGDVIEVKEASKQLAIVLEATQLAERDVPDYIEADHSKMTAKFIRIPALSDVPFAVQMEPHLIVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: LIPB_XANC5
Sequence: MDAVAAEPVSSSTAGLPAQLRDLGQQNYAPVWRAMQRFTDARGEHTADEVWVVEHAPVFTLGQAGKPEHVLAPGEIPVLQVDRGGQVTYHGPGQLVVYPLLDLRRLKIGVRDYVCKIEQALIDTLEEWNIVAERRDGAPGVYVGGAKIAALGIRVRRGCTFHGLSFNVAMDLEPFHRINPCGYQGLQVTSVLDLGGPSGMDAVKAVLLDQLARQFGLVLQPTSALPDLSLPA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYSET_PIG
Sequence: MPKPPDYSELSDSLTLPVGTGRFSGPLHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHIQQHPEEPLEGTTWTHSLKSRLLSLPFWFWTIIFLIPYLQMFLFLYSCTRADPKTVGYCIIPICLAVICNRHQAFVKASNQISRLQLIDT
What is the function of this protein?
Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes.  LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB.  GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes.  LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases.
What are the official names of this protein?
Lysosomal enzyme trafficking factor, Transmembrane protein 251.
What is the protein family that this protein belongs to?
Belongs to the LYSET family.
Protein: GUNC_CELJU
Sequence: MGHVTSPSKRYPASFKRAGSILGVSIALAAFSNVAAAGCEYVVTNSWGSGFTAAIRITNSTSSVINGWNVSWQYNSNRVTNLWNANLSGSNPYSASNLSWNGTIQPGQTVEFGFQGVTNSGTVESPTVNGAACTGGTSSSVSSSSVVSSSSSSRSSVSSSSVVSSSSSVVSSSSSSVVSGGQCNWYGTLYPLCVSTTSGWGYENNRSCISPSTCSAQPAPYGIVGGSSSPSSISSSSVRSSSSSSVVPPSSSSSSSVPSSSSSSVSSSSVVSSSSSSVSVPGTGVFRVNTQGNLTKDGQLLPARCGNWFGLEGRHEPSNDADNPSGAPMELYAGNMWWVNNSQGSGRTIQQTMTELKQQGITMLRLPIAPQTLDANDPQGRSPNLKNHQSIRQSNARQALEDFIKLADQNDIQIFIDIHSCSNYVGWRAGRLDARPPYVDANRVGYDFTREEYSCSATNNPSSVTRIHAYDKQKWLANLREIAGLSAKLGVSNLIGIDVFNEPYDYTWAEWKGMVEEAYQAINEVNPNMLIIVEGISANANTQDGTPDTSVPVPHGSTDLNPNWGENLYEAGANPPNIPKDRLLFSPHTYGPSVFVQRQFMDPAQTECAGLEGDEAAQARCRIVINPTVLEQGWEEHFGYLRELGYGILIGEFGGNMDWPGAKSSQADRNAWSHITTNVDQQWQQAAASYFKRKGINACYWSMNPESADTMGWYLTPWDPVTANDMWGQWTGFDPRKTQLLHNMWGL
What are the official names of this protein?
Endoglucanase C, Cellodextrinase C, Cellulase C, Endo-1,4-beta-glucanase C, EGC.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
Protein: TNFL6_MACNE
Sequence: MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPSPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQKHTASSLEKQIGHPSPPPEKKEQRKVAHLTGKPNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCTNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWAHSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL
What is the function of this protein?
Cytoplasmic form induces gene transcription inhibition.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 6, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Colocalizes with the SPPL2A protease at the cell membrane. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted. Note=May be released into the extracellular fluid by cleavage form the cell surface. SUBCELLULAR LOCATION: [FasL intracellular domain]: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.
Protein: TRMB_DROSI
Sequence: MVATGGQAQDQSQNQEPDVLNPTSAVTGLPQKRYYRQRAHSNPIADHSFDYPARPEDVDWRSMYPSIQQGQQVSFADVGCGYGGFLVTLGEMFPEKLSIGMEIRVKVSDYVVDRIAALRRRSADTGAYQNIACLRTNAMKYLPNYFSKGQLEKMFFLYPDPHFKRAKHKWRIINQALLSEYAYVLRKGGLVYTMTDVEDLHKWIVTHMEEHPLYERLTEEEANADPITPKLYQSSEEGAKVVRNKGDHFLAIFRRL
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS1_PSEF5
Sequence: MLTIALSKGRILDDTLPLLAEAGIVPTENPDKSRKLIIPTTQDDVRLLIVRATDVPTYVEHGAADLGVAGKDVLMEYTGQGLYEPLDLQIAQCKLMTAGAIGAAEPKGRLRVATKFVNVAKRYYAEQGRQVDIIKLYGSMELAPLIGLADKIIDVVDTGNTLRANGLEPQELIATISSRLVVNKASMKMQHARIQALIDTLRKAVESRHRG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADK_SACS2
Sequence: MRVKIVSKPTSQLNYTVEKIKNISNKLGFEVVDIDFDYVIAVGGDGTLLRAVKLGKPVIAIKAGRRGLLMDVPVDKIEDALLRLKKGDYNEEEYMLLEMVHNDKVELGFNEIGILYDRPEAIKVGISFDTERVSVEGDGVLVSTPQGSSGWGMSATNSLLYKDLNAIEIIFVNPIFYYLRSVVIPPKSLILRLEDKGYPQTARVVVDGEVVTLIKTNQEITVRVSQHKAKILRFFKLDLIGEVLHAYHI
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR18_SOYBN
Sequence: MEKSKRLFMKSKRSFRRRLPPIQSGDRIDYKNMGLISRFISEQGKILSRRVNRLTLKQQRLITIAIKQARILSSLPFLNNEKQFEKSESTARTTTLRKKKYRN
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PYLAB_XENLA
Sequence: MYKQIFLCLIIAALCATIMAEASALADADDDDDKRYVRGMASKAGAIAGKIAKVALKALGRRDS
What is the function of this protein?
PGLa and PGLa-H display a broad-spectrum of antibacterial activity against a range of Gram-positive and Gram-negative bacteria.  PGLa also displays antifungal activity against C. albicans ATCC 14053.  PGLa-H shows moderate antibacterial activity against the multidrug-resistant methicillin-resistant S. aureus (MRSA) but exhibits very little hemolytic activity.
What are the official names of this protein?
PYLa/PGLa B.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family. Magainin subfamily.