PharMolix/UniProtQA huggingface dataset:
Protein: KMT5A_MOUSE
Sequence: MARGRKMCKPRAVEAAAAAVAATAPGPEMVEQRGPGRPRSDGENVFAGQSKIYAYMSPNKCSAMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNTGNVIRSAVKSDEQKSKDTRRGPLAPFPNQKSEAAEPPKTPPPSCDSTNVAVAKQALKKSLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKNELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYVQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH
What is the function of this protein?
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins.  Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1).  H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.  Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.  Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis.  Involved in chromosome condensation and proper cytokinesis.  Nucleosomes are preferred as substrate compared to free histones.  Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.  Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
What are the official names of this protein?
N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, Histone-lysine N-methyltransferase KMT5A, Lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7, PR/SET07, SET domain-containing protein 8.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin (By similarity). Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress-dependent manner.
Protein: PYRH_BORPA
Sequence: MSSRSYKRVLLKLSGEALMGEDAFGINRSTIVRMTDEIAEVAALGVELAIVIGGGNIFRGVAPGAQGMDRATADYMGMMATIMNALALQDALKHKGVDTRVQSALNIDQVVEPYIRPKALRYLEEGKVVIFAAGTGNPFFTTDTAAALRGAEIGAEIVLKATKVDGIYSADPNKDPTATRYARISFDEAIVRRLEVMDATAFALCRDQKLPIKVFSINKFGALKRAVSGEDEGTLVHV
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KMO_DEBHA
Sequence: MASAKEDNKHQGVGIVGAGLVGCLTALAFAAKGFSVTLFELRPDPKKVTNEKNLRSINLAVSDRGIRTLKYVDSEMADRVLEHVIPMTGRMIHDLSGTKQESQAYGLFGESINSIDRSFLNDYLLDEIRHSDINVHFNHKLIRLDDLSSEEKSPKLTFLDTSESNESTMKSYEFDYVIGADGAHSQFRYQLQKSMRMNISQEYIDMQYLELSIPPNTTGDSKFHIDPNHLHIWPRHEFMLIALANEDGSFTSTFFSPWSVIESFGTSSDKFIDFFKYNFPDAFKLMGEKKLRYAFENQPRGSLMQVNAYPYHNPNGRALIIGDAAHSMVPFYGQGMNCGFEDIRVLMELIDKNNGEVSESFRQYSVLRAEDLQTISKLALDNYHEMSSKVTNVWYLFRKKIDNMLGRYGNGLFQWIPMYTMISFRGDIPYSKAIKIEKRQTKILNAIEVGTLTGFILFGAAKLAQHYHKLSNK
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Biosynthesis of nicotinic acid protein 4, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane.
Protein: FIS_ECO57
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: PUR1_HAEIN
Sequence: MCGIVGIVSQSPVNESIYAALTLLQHRGQDAAGIVTVDDENRFRLRKANGLVSDVFHQEHMLRLQGNAGLGHVRYPTAGSSSVSEAQPFYVNSPYGVTLVHNGNLTNSVELKEKVFKTARRHVNTNSDSELLLNILANHLDHIPQDHLDPQDIFYAVRKTHKDVRGAYACLAMIIGHGMVAFRDPFGIRPLVLGKREENGKTDYMFASETVALDIVGFEFVRDIAAGEAVYVTFDGELYSQQCAESAVLNPCIFEYVYFARPDSTIDGVSVYAARVHMGEKLGQKIAKEWADEIDNIDVVIPVPETSTDIALQIARVLGKPYRQGFVKNRYVGRTFIMPGQAQRISSVRRKLNTIKAEFKDKNVLLVDDSIVRGTTSEQIVEMARSAGAKKIYFASAAPEIRYPNVYGIDMPSRDELIAYGRNVDEIAELIGVDKLIFQDLTALTESVQLENPAIQGFDCSVFTGEYITGDISPEYLEKIATQRNDNAKKKREKQASNLEIYNEQ
What is the function of this protein?
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
What are the official names of this protein?
Amidophosphoribosyltransferase, ATase, Glutamine phosphoribosylpyrophosphate amidotransferase, GPATase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: MNME_CLOBL
Sequence: MKEFDTIAAVATPVGEGGISIIRISGDKSLDIVSSIFKGKNDRTLDDIKPYSMRYGFIIEKESKEMIDEVLVSYMKGPRSFTAEDTLEINCHGGVIPTKKILKELIKSGARLAEPGEFTKRAFLNGRIDLSQAEAVIDIIRSKTDLSMKSALKQAEGTLSKEINSIRNRMIKIIAHIEATVDYPEDDLEEITGQKIKVDLKEIINKIDNLISASEEGKILREGLNTVIVGKPNVGKSSLLNALINENKAIVTEIPGTTRDVIEEYINIDGIPTKIVDTAGIRETEDVVEKIGVEKSKEKIDEADLVIFMLDLSKKIDEEDIEIMDFIKNKKYIVLLNKLDLNKDLNEENHFIKELDSKYIIKTSVKNNSGLNELKECIKNLFFSGEIKSDELTVTNARHQEALIRSRESCIQAIETLSDEISIDLASIDIRNAWKYLGEITGDTLDENIIDKIFSEFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNUT1_HUMAN
Sequence: MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKSMNANTITK
What is the function of this protein?
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome.  May also bind to DNA.
What are the official names of this protein?
U4/U6.U5 tri-snRNP-associated protein 1, SNU66 homolog, hSnu66, Squamous cell carcinoma antigen recognized by T-cells 1, SART-1, hSART-1, U4/U6.U5 tri-snRNP-associated 110 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the SNU66/SART1 family.
What are the subcellular locations of this protein?
Nucleus. Note=Found in the nucleus of mitogen- activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.
Protein: DEFGA_MYTGA
Sequence: MWIESDAGVAIDRHARGACSLGEAGCATYCFYQGKHHGGCCGENYTKCLGTCYCNGSGYEYRCHSCDL
What is the function of this protein?
Shows antibacterial activity against numerous Gram-positive bacteria (Probable).  It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130).
What are the official names of this protein?
Defensin gallicin.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: IF1_LACLA
Sequence: MAKDDVIEVDGKVVDTMPNAMFTVELENGHQVLATISGKIRKNYIRILPGDKVQVELSPYDLTRGRITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_STRAQ
Sequence: MADVPADLAAVWPRVLEQLLGEGQQGIEPKDKQWIERCQPLALVADTALLAVPNEWGKRVLEGRLAPLISETLTRECGRPIRIAITVDDSAGEPPSPPAPPMHQSHQSQQGHRYPAQQRDDAPRGDAYDGYGHRPSDDGMPTRRPAYPDYQQQRPEPGAWPRTQEDLSWQQPRHGGYQDREQPSGEPYRESESYRERENEQYREQAPEQWRQPYGTGRPQQPQHDYRSGPPEHQGYEQQRPDRQDQGQGPRQGGHGPGRTGGSVPGPMGAQPAPAPGPGEPHARLNPKYLFDTFVIGASNRFAHAAAVAVAEAPAKAYNPLFIYGESGLGKTHLLHAIGHYARSLYPGTRVRYVSSEEFTNEFINSIRDGKGDTFRKRYRDVDILLVDDIQFLASKESTQEEFFHTFNTLHNANKQIVLSSDRPPKQLVTLEDRLRNRFEWGLTTDVQPPELETRIAILRKKAVQEQLNAPPEVLEFIASRISRNIRELEGALIRVTAFASLNRQPVDLGLTEIVLKDLIPGGEESAPEITAPAIMAATADYFGLTVDDLCGSSRTRVLVTARQIAMYLCRELTDLSLPKIGAQFGGRDHTTVMHADRKIRALMAERRSIYNQVTELTNRIKNG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTGTCCACA-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QOX4_STAAC
Sequence: MSTIMKHTVGFIASIVLTLLAVYVTLYTSLTFHAKLTIIFGFAFVQAGLQLLMFMHLTEGKDGRLQTFKVIFALVITLCFVVGTYWVMQGGHSSHL
What is the function of this protein?
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
What are the official names of this protein?
Probable quinol oxidase subunit 4, Quinol oxidase polypeptide IV.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase bacterial subunit 4 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TX21I_TRILK
Sequence: MKTIFALVFCCAIAVVVLGFGENEGSTIDHDQNNCKGPGSRCSNKNECCKPKDMETYTYYCGSRWDSSSGDFVRKCVICNRESSMC
What is the function of this protein?
Probable neurotoxin with ion channel impairing activity.
What are the official names of this protein?
Toxin ICK-18.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 21 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLK4_HUMAN
Sequence: MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
What is the function of this protein?
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates.  Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing.  Phosphorylates SRSF1 and SRSF3.  Required for the regulation of alternative splicing of MAPT/TAU.  Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
What are the official names of this protein?
Dual specificity protein kinase CLK4, CDC-like kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VAL1_ARATH
Sequence: MFEVKMGSKMCMNASCGTTSTVEWKKGWPLRSGLLADLCYRCGSAYESSLFCEQFHKDQSGWRECYLCSKRLHCGCIASKVTIELMDYGGVGCSTCACCHQLNLNTRGENPGVFSRLPMKTLADRQHVNGESGGRNEGDLFSQPLVMGGDKREEFMPHRGFGKLMSPESTTTGHRLDAAGEMHESSPLQPSLNMGLAVNPFSPSFATEAVEGMKHISPSQSNMVHCSASNILQKPSRPAISTPPVASKSAQARIGRPPVEGRGRGHLLPRYWPKYTDKEVQQISGNLNLNIVPLFEKTLSASDAGRIGRLVLPKACAEAYFPPISQSEGIPLKIQDVRGREWTFQFRYWPNNNSRMYVLEGVTPCIQSMMLQAGDTVTFSRVDPGGKLIMGSRKAANAGDMQGCGLTNGTSTEDTSSSGVTENPPSINGSSCISLIPKELNGMPENLNSETNGGRIGDDPTRVKEKKRTRTIGAKNKRLLLHSEESMELRLTWEEAQDLLRPSPSVKPTIVVIEEQEIEEYDEPPVFGKRTIVTTKPSGEQERWATCDDCSKWRRLPVDALLSFKWTCIDNVWDVSRCSCSAPEESLKELENVLKVGREHKKRRTGESQAAKSQQEPCGLDALASAAVLGDTIGEPEVATTTRHPRHRAGCSCIVCIQPPSGKGRHKPTCGCTVCSTVKRRFKTLMMRRKKKQLERDVTAAEDKKKKDMELAESDKSKEEKEVNTARIDLNSDPYNKEDVEAVAVEKEESRKRAIGQCSGVVAQDASDVLGVTELEGEGKNVREEPRVSS
What is the function of this protein?
Transcriptional repressor of gene expression involved in embryonic pathways, such as LEC1, ABI3, and FUS3.  Repressor of the sugar-inducible genes involved in the seed maturation program in seedlings.  Plays an essential role in regulating the transition from seed maturation to seedling growth.  Functionally redundant with VAL2/HSL1.
What are the official names of this protein?
B3 domain-containing transcription repressor VAL1, Protein HIGH-LEVEL EXPRESSION OF SUGAR-INDUCIBLE 2, Protein VP1/ABI3-LIKE 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAC_YERPG
Sequence: MRIEEGLKLGFKDVLIRPKRSTLKSRSEVALERQFTFKHSGWNWSGVPIIAANMDTVGTFRMAEVLASFDILTAVHKHYTLEQWAEFVKRSPESVLRHVMVSTGTSSADFDKMKQILALSPSLKFICIDVANGYSEHFVSFLQRAREACPDKVICAGNVVTGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVMLGGMLAGHDECEGRVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGSVDNTVRDIMGGLRSACTYVGASHLKELTKRTTFIRVAEQENRVFGTD
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Protein: CHLB_CHLAT
Sequence: MKLAYWMYAGPAHIGTLRVASSFKNVHAIMHAPLGDDYFNVMRSMLERERDFTPVTASIVDRHVLARGSQNKVVENITRKDKEERPDLIVLTPTCTSSILQEDLQNFVDRASMDSESDVILADVNHYRVNELQAADRTLEQVVRFYIEKSKKQGDLNLTKTEKPSANILGIFTLGFHNQHDCRELKRLLQELGIEINEVIPEGGSVNNLKNLPRAWFNLVPYREVGLMTAIYLEKEFGMPYVSTTPMGVVDTATCIREIEKILNSFDKDVVVDFESYIDKQTRFVSQAAWFSRSIDCQNLTGKKAVVFGDATHAASMTKILAREMGINVACAGTYCKHDADWFKEQVQGYCDEVLITDDHTEVGDLIARIEPSAIFGTQMERHIGKRLNIPCGVISAPVHIQNFPLGYRPFLGYEGTNQIADLVYNSFTLGMEDHLLEIFGGHDTKEVITKSLSTEEGLTWTSDAQAELSKIPGFVRGKIKRNTEKFARENNISEINIEVMYAAKESLNA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LOX4_ORYSJ
Sequence: MQVQGFFDRLTGRNKEAWKEGRIRGTAVLVKKDVLGLGDFHASLLDGVHNILGHKEGVAFRLVSATARDPSNGGRGKLGKPAHLEELVVTMKSTAAGESVFRVAFEWDESQGIPGAVVVTNSNRSEFFLKTLTLDGVPGKGTVVFVANSWIYPADNYQYERVFFANDTYLPSKMPAPLIPYRQEELNILRGDGKIGPYKEHDRIYRYDYYNDLGQPDKGSKLVRPVLGGSQELPYPRRGRTGRAPTKTDPNTESRLPLLDLNIYVPRDERFGHLKMSDFLGYSLKAIVEGVLPIIRTYVDTTPKEFDSFQDIMELYEGGLKVANASALAEIKKRVPFELIKSLLPVAGDQVLKLPLPHVIKEDKFAWRTDEEFAREMLAGVNPVMIKRLTNFPAKSTLDPNVYGDHTSKITEAHIKHNMEGLTVQNALKGNRLFILDHHDHFMPFLDKINKLDGNFIYASRTILLLKDDGTLKPLAIELSLPHPDGQQHGAVSKVYTPANTGVESQIWQLAKAYASVNDSAWHQLISHWLNTHAVIEPFVIATNRQLSVVHPVHKLLSPHYRDTMNINALARQTLINADGIFEKTVFPGKYALEMSSVVYKNWKFTEQALPVDLVKRGVAVPDPTSPYNVRLLIKDYPYAVDGLVIWWAIERWVGEYLAIYYPNDGVLRGDEELQAWWKEVREVGHGDLKDQDWWPKMDTVQELTRACTIIIWIASALHAAVNFGQYPYAGFLPNRPTVSRRPMPEPGTEEYAKLERGGDEADLVFIHTITSQFQTILGISLIEILSKHSSDEVYLGQRDTPEWTSDAKALDAFKRFGSRLVDIENRIKDMNGNSALKNRNGPVKMPYMLLYPNTSDVTKEKGQGLTAMGIPNSISI
What is the function of this protein?
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.  Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (By similarity).
What are the official names of this protein?
Probable linoleate 9S-lipoxygenase 4, Lipoxygenase 4.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
Protein: EBRA_BACLD
Sequence: MIAGYIFLLIAILSEAAAAAMLKISDGFARWQPSVLVVIGYGLAFYMMSLTLQVIPLSLSYATWSGAGTVLTAIIGVLWFQEKLNRRNIAGIICLVSGVVLINLS
What is the function of this protein?
Part of a multidrug efflux pump.  Confers resistance to cationic lipophilic dyes such as ethidium bromide, acriflavine, pyronine Y and safranin O.  The efflux is probably coupled to an influx of protons (By similarity).
What are the official names of this protein?
Multidrug resistance protein EbrA.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. EbrA/EbrB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YUEH_BACSU
Sequence: MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISYEEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM
What are the official names of this protein?
Uncharacterized protein YueH.
Protein: LGT_BURMS
Sequence: MIIHPNFDPVAIHLGPLAVRWYGLMYLVGFILAIVVGRLRLKLPHVAAQGWSAKDIDDMMFYGVLGVVLGGRLGYVLFYKAGYYFSHPLDIFRVWEGGMSFHGGFLGVTLAMALFAWQRKRHWLEVTDFVAPMVPTGLAAGRLGNFINGELWGRVTSPDAPWAMLFPGASRDDAAWLAAHQDIAAKWNLNEVFLSHQMLPRHPSQLYEIALEGIALFFVLWFFSRKPRPMGAISALFLIGYGAARFTVEFAREPDDFLGLLTFGLSMGQWLSLPMIVAGVLMMIWAYRRGGVAKQA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MOES_RAT
Sequence: MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKAFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERALLENEKKKRELAEKEKEKIEREKEELMEKLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLASEMAELTARVSQLEMARKKKESEAEECHQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEHDEQDENGAEASAELRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTTNDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM
What is the function of this protein?
Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex.  Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton.  Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement.  These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction.  The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (By similarity).  Modulates phagolysosomal biogenesis in macrophages (By similarity).  Participates also in immunologic synapse formation (By similarity).
What are the official names of this protein?
Moesin, Membrane-organizing extension spike protein.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts (By similarity).
Protein: BT3A2_HUMAN
Sequence: MKMASSLAFLLLNFHVSLLLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSNLHVEVKGYEDGGIHLECRSTGWYPQPQIQWSNAKGENIPAVEAPVVADGVGLYEVAASVIMRGGSGEGVSCIIRNSLLGLEKTASISIADPFFRSAQPWIAALAGTLPILLLLLAGASYFLWRQQKEITALSSEIESEQEMKEMGYAATEREISLRESLQEELKRKKIQYLTRGEESSSDTNKSA
What is the function of this protein?
Plays a role in T-cell responses in the adaptive immune response.  Inhibits the release of IFNG from activated T-cells.
What are the official names of this protein?
Butyrophilin subfamily 3 member A2.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. BTN/MOG family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.