PharMolix/UniProtQA huggingface dataset:
Protein: DAPB_STRR6
Sequence: MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQGIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELKEFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKTAELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGLTLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADRJ_PENRO
Sequence: MGFFSSTQPPRPATVPSDEIIPLHFWNTALCMRGTVLDISLKFDDVLDTSKLRSALEELLEMKDWRQLGARLRMNPNGRLEYHIPTRFDASRPAFAMTNAQHETSIADHPLGARIPHATSTPAIFPSPDVLSPLLRSEDAPKNIDDWICSDRPQLSIHIITFSDATLITVTWLHTLTDVMGMALILNAWTALLRGNREAVPKLQGFRLDPLTELGQRTPAEKYMHFNRVFGRKEFWWFIGLNVLDRLWYRQEERRTICIPAASLRNLCQQSSSEICASRGKEEPVPFVSESDVLLGWWVRSLYSALGLRTDQTILVNNALNLRTSLHESFTSNNSAYMGNALCMSPTFLRGHQVADEPLGQIALRIRESVTEQRTPEQVEAMTALQMQTMEQTGYLALVGDPRMMLLSCSNWHKARLFDIDFSSAVLQSSGPSSLQNPQHTGKPCYVNGVQHSANSFRNVLSVIGKDAGGNWWLTGVLRTDAWTHIEKQLHKLGSS
What is the function of this protein?
Acetyltransferase; part of the gene cluster that mediates the biosynthesis of andrastins, meroterpenoid compounds that exhibit inhibitory activity against ras farnesyltransferase, suggesting that they could be promising leads for antitumor agents (PubMed:28529508).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase adrD via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (By similarity).  DMAO is then converted to farnesyl-DMAO by the prenyltransferase adrG (By similarity).  The methyltransferase adrK catalyzes the methylation of the carboxyl group of farnesyl-DMAO to farnesyl-DMAO methyl ester which is further converted to epoxyfarnesyl-DMAO methyl ester by the FAD-dependent monooxygenase adrH (By similarity).  The terpene cyclase adrI then catalyzes the carbon skeletal rearrangement to generate the andrastin E, the first compound in the pathway having the andrastin scaffold, with the tetracyclic ring system (By similarity).  The post-cyclization tailoring enzymes adrF, adrE, adrJ, and adrA, are involved in the conversion of andrastin E into andrastin A.  The short chain dehydrogenase adrF is responsible for the oxidation of the C-3 a hydroxyl group of andrastin E to yield the corresponding ketone, andrastin D.  The ketoreductase adrE stereoselectively reduces the carbonyl moiety to reverse the stereochemistry of the C-3 position to yield andrastin F.  The acetyltransferase adrJ is the acetyltransferase that attaches the acetyl group to the C-3 hydroxyl group of andrastin F to yield andrastin C.  Finally, the cytochrome P450 monooxygenase adrA catalyzes two sequential oxidation reactions of the C-23 methyl group, to generate the corresponding alcohol andrastin B, and aldehyde andrastin A (By similarity).
What are the official names of this protein?
Acetyltransferase adrJ, Andrastin A biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: Y1394_METJA
Sequence: MMWGMPNIKLKFIYLCILLFVFMASMLNSVSGLKTIFYDDFENWSGWYNYSSGAVEQSSNYAHSGIYSLRKFLNDDPNGGYKLIGKEIGRDIVMEGWIYRPLPYVSGRWDRIGIEDENFNGYSIRIEHDYNKIAIETRENGIAVNTLVITNWNPPENQWYYFKFYIYSNGTLRLEVYYENGSLGATVSAIDNIYTKFDRVVVHGGQDYYVDDLRISDLYPPLRVRYIEEYNATATVDGTGKTNYSYGLTGHIIIENTAPYKEDTLNDVWVAVDIKNNASGLRLVYNGTPKGVFIESSAPAYTNLPNANTYIHIPILPNNSYVEYEFDIDASQTLPILVNETYDVTKIPANKMSEWTVNLIVYLNKNLVPNGENVNVNVIKYLSNGQFYDNFENWTGWNQYKNGIVQWSSIQSHSGNYSLEKYGISTSLNNDPNGGYKLLPKEIGRDVVISGWVYRPSNWGGGPIDRIGLEDENFDGYSFEVNHYSNYISIDRRTNGNPTEISPEVYWNPPEDEWYYFELKIYSNGTITFSTYYQNGSLAATVSTIDNTYTKFDRVVIHGGYVYYVDDLEVNSKNFDFYGDKNWKYLEITSANSSEGTAVLFDGDYFKKDYNTSNLNAINWTNITLNWSNDSATLVFNVLGNYSYSERDNILAKYGFAKILFNYNGTNTNTSIKGVYASGSYSISTDHGTTGEINIWIENVTFKNDAKSYSFNLTNLNIWAVNKSAYELYWNPFNKSIWIDGSNYTITPNIDIPPGEVWNSKTYNFTFSGVPIVWANCSFTLSKKDYILLNEVSQIGSSYVVVEEIYVVGSYLIKVTKHIVPDADGTYDIYIVVENIGSVKTPEYVYVYDLIPKNFTVSDEWVNQSSMLIAEGNHTITTNPRYNLSMWWALHAIYPGADGDGNWNDTAEILANKTVVIHYKLNGTGEFYPSDAFIVGIDPTNSLLPTTSPKITTVAGTVENNFEIFLILINVIFGLGILTKRNIRNNK
What are the official names of this protein?
Uncharacterized protein MJ1394.
What is the protein family that this protein belongs to?
To M.jannaschii MJ1393 and A.fulgidus AF2028.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PETN_POPAL
Sequence: MDIVSLAWAALMVVFTFSLSLVVWGRSGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single- pass membrane protein.
Protein: NRDR_ACIB5
Sequence: MHCPFCNAADSKVIDSRLAAEGCQIRRRRECVSCGERFTTFESYEVVMPRVIKSNGKNEPFDEAKLRRSLMHALQKRPVTQEQIETVLSDIQLQIRRLGERDVKSRTIGEIVMQSLFALDHVAYVRFASVYQDFQDVEAFRRQIEQMQQREH
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: TINF2_HUMAN
Sequence: MATPLVAGPAALRFAAAASWQVVRGRCVEHFPRVLEFLRSLRAVAPGLVRYRHHERLCMGLKAKVVVELILQGRPWAQVLKALNHHFPESGPIVRDPKATKQDLRKILEAQETFYQQVKQLSEAPVDLASKLQELEQEYGEPFLAAMEKLLFEYLCQLEKALPTPQAQQLQDVLSWMQPGVSITSSLAWRQYGVDMGWLLPECSVTDSVNLAEPMEQNPPQQQRLALHNPLPKAKPGTHLPQGPSSRTHPEPLAGRHFNLAPLGRRRVQSQWASTRGGHKERPTVMLFPFRNLGSPTQVISKPESKEEHAIYTADLAMGTRAASTGKSKSPCQTLGGRALKENPVDLPATEQKENCLDCYMDPLRLSLLPPRARKPVCPPSLCSSVITIGDLVLDSDEEENGQGEGKESLENYQKTKFDTLIPTLCEYLPPSGHGAIPVSSCDCRDSSRPL
What is the function of this protein?
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection.  Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.  Plays a role in shelterin complex assembly.  Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
What are the official names of this protein?
TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere. Note=Associated with telomeres. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus matrix.
Protein: IDI2_STAS1
Sequence: MSDNKREQRKNEHVEIAMAQGDATISDFDEIRFVHHSIPSVDVDDIDLTSQLKDFTLDQPLYINAMTGGSEWTKQINEKLAVIARETGIAMAVGSTHAALRNSKMASSFSIVRDTNPNGIIFSNVGADVPVDKAVESVKLLDAQALQVHVNAPQELVMPEGNRTFSTWMENLAQIVSRVDVPVIVKEVGFGMSKETIKSLNEIGVRYVDVSGRGGTNFVDIENERRTYKDMDYLGLWGQTTVESLLESASYQQDMDILASGGVRTPLDAVKCLALGASAVGMSRPFLNQVENYGITETLNYTEQFTDHMKKIMTMLDVKTIKDLKQTQMVFSPKLQSWIEQRGLDIR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRL_ESCF3
Sequence: MTLPSGHPKSRLIKKFTALGPYIREGKCEDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAGDWKSVPVKDAEVVERLEHTLREFHEKLRELLSTLNLKLEPADDFRDEPVKLTA
What is the function of this protein?
Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes.  Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32.
What are the official names of this protein?
Sigma factor-binding protein Crl.
What is the protein family that this protein belongs to?
Belongs to the Crl family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_VIBC1
Sequence: MTHWIAGEWVQGQGEAFTSLSPYNQEVIWQGNGATAEQVNQAVSAAREAFVDWKKRPFAEREAIVLAFAEKVKENSEKIAEVIAKETGKPIWETRTEAAAMAGKIAISIRAYHDRTGEATREAAGNQIVLRHRPLGVMAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSEQTPWTGELAMKLWEEVGLPKGVINLVQGAKETGIALADAKGIDGVLFTGSANTGHVLHRQFAGQPGKMLALEMGGNNPMVISDNYGDLDATVYTIIQSAFISAGQRCTCARRLYIPFGDKGDAVITKLVEATRNIRVDRPFAEPAPFMGPQISVAAAKFILDAQANLQSLGGESLIEAKAGEAAFVSPGIIDVTNIAELPDEEYFGPLLQVVRYEGLEKAVELANDTRFGLSAGLVSTDDQEWEYFVDHIRAGIVNRNRQLTGASGDAPFGGPGASGNLRPSAYYAADYCAYPMASMEGQETVLPATLSPGVSL
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: CYC_ACENE
Sequence: ASFAEAPPGNPAAGEKIFKTKCAQCHTVDKGAGHKQGPNLNGLFGRQSGTTAGYSYSAANKNMAVNWGYNTLYDYLLNPKKYIPGTKMVFPGLKKPQDRADLIAYLKQSTAA
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: TRPA_SALA4
Sequence: MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTLIDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQCFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQVGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADDDLLRQVASYGRGYTYLLSRSGVTGAENRGALPLHHLIEKLKEYHAAPALQGFGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPEQMLAELRSFVSAMKAASRA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: HYBA_ECOLI
Sequence: MNRRNFIKAASCGALLTGALPSVSHAAAENRPPIPGSLGMLYDSTLCVGCQACVTKCQDINFPERNPQGEQTWSNNDKLSPYTNNIIQVWTSGTGVNKDQEENGYAYIKKQCMHCVDPNCVSVCPVSALKKDPKTGIVHYDKDVCTGCRYCMVACPYNVPKYDYNNPFGALHKCELCNQKGVERLDKGGLPGCVEVCPAGAVIFGTREELMAEAKKRLALKPGSEYHYPRQTLKSGDTYLHTVPKYYPHLYGEKEGGGTQVLVLTGVPYENLDLPKLDDLSTGARSENIQHTLYKGMMLPLAVLAGLTVLVRRNTKNDHHDGGDDHES
What is the function of this protein?
Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover.
What are the official names of this protein?
Hydrogenase-2 operon protein HybA.
What are the subcellular locations of this protein?
Periplasm.
Protein: ERA_THEP1
Sequence: MSIKSGFVALAGKPNVGKSTFINVVMGRKVVIVSDKPQTTRNRINCIYTDRDSQIIFVDTPGIHKPLHRLGEYMVKAAVQALKGVDLILFMLDAADGFTKTDEHVAKIVSESGTKTIIAVNKIDVAGEEKAKAVGQLAKSMVENVVSVHYISALKGEGVFEVLEKIKEELPEGPQYYPEDMVTDRPLSFMAAEIIREKIFHLTRQEVPHSTAVVIEEIKDRPNGVLYIRANIYVERDSQKGILIGKNGSMIKKIGTLAREELEFLVGRKVYLDLNVKVKENWREKDFIILQEIGLKDDIK
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: VATD_CHLMU
Sequence: MSSQIKLTKNSYRAEKQKLNLLGMYLPTLKLKKALLQAEVQSAMRSAAESMAANEQARDRMHAFAELFSIPLYTDAVEQCFSIDIFEKDVENIAGVEVPLLKRVVLTSLEYSLLDTPIWIDSLIASAKEYVLSKIYAENAQERLRLLEEELRRVSIRVNLFEKKLIPTTSQTIKKIAIFLSDRSITDVGQMKMAKKKIQQHKE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: UD2A3_PONAB
Sequence: MRSEKSALVFLLLQLFCVGCGFCGKVLVWPCDMSHWLNVKVILEELIVRGHEVTVLTHSKSLLIDYRKPSALKFEVVHMPQDKTEGNEVFVDLALNVLPGLPTWQSVIKLNDFFVEIRGTLKMMCESFIYNQTLMKKLQETNYDVMLIDPVIPCGDLMAELLAVPFVLTLRISLGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVFFHFWIQDYDYHFWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKEMENFVQSSGEDGIVVFSLGSLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGTNTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVTTNSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHNLTWFQHYSIDVIGFLLACVATAIFLFTKCCLFSCQKFNKTRKIEKRE
What is the function of this protein?
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion.  They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
What are the official names of this protein?
UDP-glucuronosyltransferase 2A3, UDPGT 2A3.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GCH1_STRCO
Sequence: MTDPVTLDGEGQIGEFDEKRAENAVRELLIAVGEDPDREGLRETPARVARAYREIFAGLWQEPEDVLTTTFDLGHDEMVLVKDIEVFSTCEHHLVPFRGVAHVGYIPSTSGKITGLSKLARLVDVYARRPQVQERLTTQIADSLMEILEPRGVIVVVECEHMCMSMRGIRKPGAKTLTSAVRGQLRDVATRNEAMSLIMAR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: DUS_RICBR
Sequence: MIKIGNIELSSNIILAPMSGVTDLEFRRLVKRFGAGLVVSEMIASRAMIVESRQSLQKCSIMQDDATSACVQLAGCEPNVIAEAAKMNEDMGAKIIDLNFGCPAKKVVNGYSGSALMRDEGLAAKIFEAAVKAVKIPVTVKMRMGWDDQTKNAPTLAKIAERSGIQMVTVHGRTRCQFYSGNADWEFIKNVKEAVKIPVIANGDITNFAKAKEALEKSSADGVMVGRGAYGKPWLISQIDHYLKTGEEKPAPSIESQLDIVLEHYQAIVDYYGESAGVPIARKHMGWYSSGLPNSAEFRGAVNLMNDPIAVKDKIVEFYTSVINRE
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
What are the official names of this protein?
Probable tRNA-dihydrouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the Dus family.
Protein: DDX59_HUMAN
Sequence: MFVPRSLKIKRNANDDGKSCVAKIIKPDPEDLQLDKSRDVPVDAVATEAATIDRHISESCPFPSPGGQLAEVHSVSPEQGAKDSHPSEEPVKSFSKTQRWAEPGEPICVVCGRYGEYICDKTDEDVCSLECKAKHLLQVKEKEEKSKLSNPQKADSEPESPLNASYVYKEHPFILNLQEDQIENLKQQLGILVQGQEVTRPIIDFEHCSLPEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVKIVVVDEADTMLKMGFQQQVLDILENIPNDCQTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVEDPAKKKKLFEILNDKKLFKPPVLVFVDCKLGADLLSEAVQKITGLKSISIHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITFINNNSKRLFWDIAKRVKPTGSILPPQLLNSPYLHDQKRKEQQKDKQTQNDLVTGANLMDIIRKHDKSNSQK
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX59, DEAD box protein 59, Zinc finger HIT domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX59 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Exhibits granular localization in the nucleus, as well as in the cytoplasm.
Protein: DXR_GEOUR
Sequence: MKKLAILGSTGSIGVSTLDIVAAHPDKFQVVALTAGGNLDLLKKQIEEFSPQLVAVLNEELAQKLQQMLSGKGPAILHGVEGMIAAATAADADMVVAAIVGAAGLVPTAAAIKAGKDIALANKETLVTAGRLIMDMVKAHGVKLYPVDSEHSAVFQSLQGHRMEDVKQIILTASGGPFFTWPAEKLAQVTVSDALNHPNWSMGQKITIDSASMMNKGLEVIEARWLFDIPAEKIAVNIHPQSIIHSMVEYIDGCVMAQLGIPDMKAPIAYALTYPGRVPTGVKPLDLTALSGLTFFNPDYSRFPALKLAYRALEDGESMPTVMNAANEVAVGAFLNGRIKFTAIAEAIEKTMDFHQPHLLNTIEEVLLVDRWGREKCKELLGIDKQ
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: STK11_RAT
Sequence: MDVADPQPLGLFPEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPCDCAPPLSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRSMTVVPYLEDLHGRAEEEEDEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLPKAVCVNGTEPQLSSKVKPEGRPGAANPARKVCSSNKIRRLSACKQQ
What is the function of this protein?
Has a role in spermiogenesis.
What are the official names of this protein?
Serine/threonine-protein kinase STK11, Liver kinase B1 homolog, LKB1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Membrane. Mitochondrion. Note=A small fraction localizes at membranes. Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis (By similarity). PTEN promotes cytoplasmic localization (By similarity). SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta).
Protein: Y2149_BRADU
Sequence: MNALSEHILSELRRLLSEMSDGGSVGPSVYDTAQALRFHGNVTGRQDAYAWLIAQQQADGGWGSADFPLFRHAPTWAALLALQRADPLPGAADAVQTATRFLQRQPDPYAHAVPEDAPIGAELILPQFCGEAASLLGGVAFPRHPALLPLRQACLVKLGAVAMLPSGHPLLHSWEAWGTSPTTACPDDDGSIGISPAATAAWRAQAVTRGSTPQVGRADAYLQMASRATRSGIEGVFPNVWPINVFEPCWSLYTLHLAGLFAHPALAEAVRVIVAQLDARLGVHGLGPALHFAADADDTAVALCVLHLAGRDPAVDALRHFEIGELFVTFPGERNASVSTNIHALHALRLLGKPAAGASAYVEANRNPHGLWDNEKWHVSWLYPTAHAVAALAQGKPQWRDERALAALLQAQRDDGGWGAGRGSTFEETAYALFALHVMDGSEEATGRRRIAQVVARALEWMLARHAAHGLPQTPLWIGKELYCPTRVVRVAELAGLWLALRWGRRVLAEGAGAAP
What are the official names of this protein?
Uncharacterized protein blr2149, ORF7.
Protein: SYN_STAS1
Sequence: MNTTIKEAKQYIGQEVTIGAWLTNKRSSGKIAFLQLRDGTGFIQGVVAKAEVDEEIFQKAKEITQESSLYVTGVISEDNRSDIGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLWLRSKKQHAVMKIRNEIIRATYEFFNDNGFTKIDPPILTASAPEGTSELFHTKYFDQDAFLSQSGQLYMEAAAMAHGRVFSFGPTFRAEKSKTRRHLIEFWMIEPEMAFCEHAQSLEVQEQYVTHVVKSVLNHCKLELKALDRDTSKLEKVTTPFPRITYADAVIFLKEQGFDDIEWGEDFGAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEDTVLCADLIAPEGYGEIIGGSERINDLELLEERLSQFELDAESYSYYLDLRRYGSVPHSGFGLGLERTVAWLSGVEHVRETAPFPRLLNRLYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_CLOK5
Sequence: MSEIKVGENETIESALRRFKRKCARAGVLSEVRKREHYEKPSVKRKKKSEAARKRKFK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RNPA_KOCRD
Sequence: MLPTRHRMRTSAHFSTTVRSGARGGRRNVVVSVRLSTGAPSRVGFVVSKAVGNAVTRNKVKRRLRELSAETVRERPEGMDLVVRALPPAATAPWDELARDYRSAVATAVRRCA
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL15_VARPS
Sequence: MELNGIKPAAGAKHAKRRVGRGIGSGIGKTAGRGHKGQKSRAGGFHKVGFEGGQMPLQRRLPKRGFKSHLLKFNAEVTLTALEQLGLAEVDILALKQAGLVGQLAKVVKIVKTGELTKAVKLTGVGATAGAKAAIEAAGGSVA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: MIAB_HELPG
Sequence: MKVYIETMGCAMNSRDSEHLLSELSKLDYKETSDPKTADLILINTCSVREKPERKLFSEIGQFAKIKKPNAKIGVCGCTASHMGADILKKAPSVSFVLGARNVSKISQVIHKEKAVEVAIDYDESAYAFEFFEKKAQIRSLLNISIGCDKKCAYCIVPHTRGKEISIPMDLILKEAEKLANNGTKELMLLGQNVNNYGARFSSEHAKVDFSDLLDKLSEISGIERIRFTSPHPLHMNDGFLERFAKNPKVCKSIHMPLQSGSSAVLKMMRRGYSKEWFLNRVERLKALVPEVGISTDIIVGFPNESDKDFEDTMEVLEKVRFDTLYSFIYSPRPFTEAGAWKERVPLEVSSSRLERLQNRHKEILEEKAKLEVGKTHVVLVENRREINNQIVGFEGRSDTGKFIEVACKEKRNPGELVEVEIISHSKGRLMATTKGN
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX24_BOVIN
Sequence: MEVYIPSFRYEESDLERGYTVFKIEVLMNGRKHFVEKRYSEFHALHKKLKKCIKTPEIPSKHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNVRHLPSLPKTESYGSFDETESEESSKLSHQPVLLFLRDPYVLPAASDFPNVVIEGVLHGIFYPHLQPR
What is the function of this protein?
May be involved in several stages of intracellular trafficking.
What are the official names of this protein?
Sorting nexin-24.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GCH1_VIBPA
Sequence: MSGLSESAKLVKEALEQRGLETPMRPNAVSREEKKEKIEHHMREILTLLQLDLTDDSLEETPHRIAKMYVDEIFSGLDYSNFPKITVIENKMNVSEMVRVKDITVTSTCEHHLVTIDGKAAVAYIPRGKIIGLSKINRIVRFFAQRPQVQERMTQQILVALQTLLESDDVAVTIDATHYCVKSRGVMDATSETTTTALGGIFKSNPATRAEFLHGLR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.