PharMolix/UniProtQA huggingface dataset:
Protein: RL2_CLOD6
Sequence: MAIKKFRPTSPALRQMTVLVSDEITCNQPEKSLLVNLKKNAGRNVHGRITVRHRGGGQKRKYRIIDFKRDKDGIPAKVATIEYDPNRTANIALLNYADGEKRYILAPVGINVGDTILSGLGADIKPGNCLALKDMPVGTIIHNIELKPGKGAQLVRSAGVSAQLMAKEGKNALLRLPSGEMRLVSINCKATIGQVGNIEHGNVVIGKAGRKRHMGIRPTVRGSVMNPNDHPHGGGEGRSPIGRPSPVTPWGKPALGYKTRKKNKASNKLIVSRRTK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MIAA_BORBU
Sequence: MKEDRVVFIFGPTAVGKSNILFHFPKNKAEIINVDSIQVYKEFNIASSKPSKNLMKHIKHHLVDFLDPEKDYTIGIFYEQALKIVKEIRQKKKIPIFVGGTAFYFKHLKDGFPSTPLVTSKIRIYVNNLLELKGKSYLLKELKNVDPIRFNMLNKNDIYRIKRSLEVYYQTGIPISQFQKKQSSEFKNIVIIGLKRSFEDLKTRISIRINEMLNSGLLSEIKGLFSKGYNENTPAFKGIGYNEFLLWKSRPCYGLNDIIGLINKNSFLYAKRQMTFFAKISDVLWLHPEDDLDNILNLIFKVDKEI
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: HRCA_GLOVI
Sequence: MSSFSFESSARLPLNPRFKQILHATVKSYIDTAEPVGSKMLTQQYNFGLSSATIRNAMAVLESWGLLFQPHTSAGRIPSDSGYRVYVDELISPPTELIQQMRAALAENLGERQDLESLLQGATRLLATLSGCVALITAPQSVFVSVRHLQIVHIGEGRALVIVVTDALQTRSFLLDLPQPEMAEQLETLNNFLNLQLQNRRLDDLNAAAVEAMGGEFHWYTDFLRGLIALLQRVLQPPTGQLYVSGVGEILKQPEFAEPERIQAIVQLLEVERERLGPLISPTQRHSRQIVVRIGAENPLGPMQFCSLVSSTYYLNEVPVGSVGVLGPTRLPYDRAIASVQAASDHLCQVMQAEDEPHRW
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: GDI1_YEAST
Sequence: MDQETIDTDYDVIVLGTGITECILSGLLSVDGKKVLHIDKQDHYGGEAASVTLSQLYEKFKQNPISKEERESKFGKDRDWNVDLIPKFLMANGELTNILIHTDVTRYVDFKQVSGSYVFKQGKIYKVPANEIEAISSPLMGIFEKRRMKKFLEWISSYKEDDLSTHQGLDLDKNTMDEVYYKFGLGNSTKEFIGHAMALWTNDDYLQQPARPSFERILLYCQSVARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDTPIDEVLYKKDTGKFEGVKTKLGTFKAPLVIADPTYFPEKCKSTGQRVIRAICILNHPVPNTSNADSLQIIIPQSQLGRKSDIYVAIVSDAHNVCSKGHYLAIISTIIETDKPHIELEPAFKLLGPIEEKFMGIAELFEPREDGSKDNIYLSRSYDASSHFESMTDDVKDIYFRVTGHPLVLKQRQEQEKQ
What is the function of this protein?
Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4.  Plays an essential role in the yeast secretory pathway (PubMed:8157010).  Extracts GDP-bound YPT7 from vacuolar membranes, antagonizing vacuolar membrane fusion (PubMed:11118206).
What are the official names of this protein?
Rab GDP-dissociation inhibitor, Rab GDI, Secretory pathway GDP dissociation inhibitor.
What is the protein family that this protein belongs to?
Belongs to the Rab GDI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_ECO5E
Sequence: MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: Y2434_SYNC1
Sequence: MTFALPDNATLSLFLLPLLVFFARIIDVSIGTLRIIFVARSLKGWAGVLGFFESLIWVLAISQVMQNLTNVWTYIAFALGFATGNYVGVLIEERIAIGSLIVRIITRKDATVLTEHLWKAGYGVTNLQAHGETGPVRLIFTVCRRRDVKDVLRMVKQFNPRAFYTIEDVRFVQDNLPVVPRRHGIMSRLALRNRK
What are the official names of this protein?
UPF0316 protein Pcar_2434.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAC1F_MOUSE
Sequence: MSESEVGKDTTPEPSPANGTGPGPEWGLCPGPPTVGTDTSGASGLGTPRRRTQHNKHKTVAVASAQRSPRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVVNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTDTPGDEDEEEGTMASCTRCLNKIMKTRICRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPLWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASGDAGTAKDKGREKSSEGNPPKENKVLVPGGENEDAKGARSEGAAPGMEEEEEEEEEEEEEEEEEEENGAGHVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHIFTSLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKESKGSFLIYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATVNSRAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDTSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGLVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSSFAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLKIKTEGNLDQANQELRMVIKKIWKRIKQKLLDEVIPPPDEEEVTVGKFYATFLIQDYFRKFRRRKEKGLLGREAPTSTSSALQAGLRSLQDLGPEIRQALTYVTEEEEEEEEAVGQEAEEEEAENNPEPYKDSIDSQPQSRWNSRISVSLPVKEKLPDSLSTGPSDDDGLAPNSRQPSVIQAGSQPHRRSSGVFMFTIPEEGSIQLKGTQGQDNQNEEQELPDWTPDLDRAGRDSFEPSPFTTSLVQQHVNGHMSTPTFAAPHACRSEPSFTIQCLQRLGSCEDLPIPGTYHRGRTSGPSRAQGSWAAPPQKGRLLYAPLLLVEESTVGEGYLGKLGGPLRTFTCLQVPGAHPNPSHRKRGSADSLVEAVLISEGLGLFAQDPRFVALAKQEIADACHLTLDEMDSAASDLLAQRTISLYSDEESILSRFDEEDLGDEMACVHAL
What is the function of this protein?
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.  The isoform alpha-1F gives rise to L-type calcium currents.  Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.  They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines (By similarity).  Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization.
What are the official names of this protein?
Voltage-dependent L-type calcium channel subunit alpha-1F, Voltage-gated calcium channel subunit alpha Cav1.4.
What is the protein family that this protein belongs to?
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1F subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TX34_PHONI
Sequence: MKMKLLGIILLVSFPFVLGFAGIPIEEGENSVEVGEVERSCINVGDFCDGKKDDCQCCRDNAFCSCSVIFGYKTNCRCEVGTTATSYGICMAKHKCGRQTTCTKPCLSKRCKKNHG
What is the function of this protein?
This toxin is a potent and practically irreversible antagonist of both Cav2. 1/CACNA1A and Cav2. 2/CACNA1B calcium channels, while it displays a partial and rapidly reversible block of Cav2. 3/CACNA1E calcium channels and no effect on Cav3/CACNA1 calcium channels.  Inhibits glutamate uptake from rat brain synaptosomes by an interaction between cysteines from both glutamate transporter and toxin.  Blocks potassium-induced exocytosis of synaptic vesicles in brain cortical synaptosomes with an IC(50) of 1. 1 nM.  In mice, induces rapid general flaccid paralysis followed by death in 10-30 minutes at dose levels of 5 ug per mouse.  In rat brain, inhibits glutamate release, neuronal death and loss of neurotransmission in the hippocampus resulting from ischemia.
What are the official names of this protein?
Omega-ctenitoxin-Pn3a, Omega-CNTX-Pn3a, Neurotoxin Tx3-4, Omega-phonetoxin-2A, Omega-phonetoxin-IIA, Omega-Ptx-IIA, PF3, Phoneutriatoxin 3-4, Pn3-4A.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 04 (omega-agtx) family. 03 (type II/III omega-agtx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HYPA_ECO57
Sequence: MHEITLCQRALELIEQQAAKHGAKRVTGVWLKIGAFSCVETSSLAFCFDLVCRGSVAEGCKLHLEEQEAECWCETCQQYVTLLTQRVRRCPQCHGDMLQIVADDGLQIRRIEIDQE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: ANMK_YERPP
Sequence: MKSGRFIGVMSGTSLDGVDVVLAAIDERMVAQQASYTHPIPLQLKKDILGMCQGQSTTLSAVGKLDAQLGILFAEAVLALLAKEGLSAQDITAIGCHGQTVWHEPLGEPAFTMQLGDNNRIAAMTQIATVGDFRRRDMAYGGQGAPLVPAFHHALLAHATEKRMVLNIGGIANLSVLLPDSPIRGFDTGPGNMLMDAWIWRNCSLPYDKDACWALSGHVNQPLLEQMFNDPYFRLPAPKSTGREYFNAAWLDKQLARIPGVTAEDIQATLAELTAVSITEQVRLAGGCDRLLVCGGGARNPLVMARISALLSGTEVCTTDDAGIRGDDMEALAFAWLAFRTLSGKPGNLPSVTGASRETILGAVHPVSSW
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: LDHD_STAAS
Sequence: MTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEDDVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVINTPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFFSDEAVQNLVEGGLNAALSVINTSTCETRLN
What are the official names of this protein?
D-lactate dehydrogenase, D-LDH, D-specific 2-hydroxyacid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: RS2_SALNS
Sequence: MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKISARKGKILFVGTKRAASEAVKEAANSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFEKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVSLYLGAVAATVREGRSQDLASQAEESFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: GLGB_PSEPK
Sequence: MNVTTRENGGLRQRDLDALARAEHADPFAVLGPHGDGAGGQVVRAFLPNALKVRIQARDDGRVLAEMEQGSLPGLFSAHLDKAQPYQLHIVWAGGEQVTEDPYSFGPQLGDMDLHLFAEGNHRDLSGRFGAQPTQVDGIDGVCFSVWAPNARRVSVVGDFNNWDGRRHPMRLRHGAGVWELFIPRLGVGETYKFEVLGKDGILPLKADPLARATELPPSTASKVAGELSHAWQDHDWMAQRAQRHAYNAPLSIYELHPGSWRCELDEAGEIGRFYNWRELAERLVPYVQELGFTHIELLPIMEHPFGGSWGYQPLSMFAPTSRYGSAEDFAAFIDACHQGGIGVLLDWVPAHFPTDEHGLARFDGTALYEYDNPLEGYHQDWNTLIYNLGRNEVRGFMMASALHWLKHFHIDGLRVDAVASMLYRDYSRKAGEWVPNRHGGRENLEAIDFIRHLNGVAAHEAPGALIIAEESTAWPGVSQPTQQGGLGFAYKWNMGWMHDTLHYIQNDPVHRTYHHNEMSFGLIYAYSEHFILPISHDEVVHGKHSLIDKMPGDRWQKFANLRAYLTFMWAHPGKKLLFMGCEFGQWREWNHDAELDWYLLQYPEHQGVQRLVGDLNRLYREEPALHEQDCQPQGFQWLIGDDAQNSVYAWLRWSSSGEPVLVVANFTPVPREGYRIGVPFGERWQELLNSDAELYAGSNVGNLGAVASDEVASHGQPLSLALNLPPLGVLIMKPA
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: SERDH_PSEAE
Sequence: MKQIAFIGLGHMGAPMATNLLKAGYLLNVFDLVQSAVDGLVAAGASAARSARDAVQGADVVISMLPASQHVEGLYLDDDGLLAHIAPGTLVLECSTIAPTSARKIHAAARERGLAMLDAPVSGGTAGAAAGTLTFMVGGDAEALEKARPLFEAMGRNIFHAGPDGAGQVAKVCNNQLLAVLMIGTAEAMALGVANGLEAKVLAEIMRRSSGGNWALEVYNPWPGVMENAPASRDYSGGFMAQLMAKDLGLAQEAAQASASSTPMGSLALSLYRLLLKQGYAERDFSVVQKLFDPTQGQ
What is the function of this protein?
NAD-dependent L-serine dehydrogenase that catalyzes the oxidation of L-serine and methyl-L-serine and is possibly involved in serine catabolism.  Has low activity toward beta-hydroxyisobutyrate.
What are the official names of this protein?
NAD-dependent L-serine dehydrogenase, L-serine 3-dehydrogenase (NAD(+)).
What is the protein family that this protein belongs to?
Belongs to the HIBADH-related family.
Protein: IF3_ACIBY
Sequence: MKQPDRNQQQGAKSNRPAINDEIRAKEVRLVGADGEQKGIVSLNEALRAAEDADLDLVEIVANAEPPVCKIMDYNKHLFDLKQKQKDAKKKQHQVQVKEIKLRPATDVGDYQVKLRAILKFLEEGNKVKITLRFRGREMAHQQLGLAQLQKIEADVAELGVVEQAPKMEGRQMGMLLGPKKKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_COXBN
Sequence: MYAQPKLTSAEYVQHHMSHWKLNLHNFTFTDGGFWTLNLDTLIISVVLGALFILIFYIVARRATASVPGKWQNAIEMAVEAADGTVKDSFHGDRSLVAPLALTIFIWVFLMNFMDLVPVDLIPRLFQMGGVEHFKAVPTADPTLTFAMSITVFVLVIFYNFKMKGAIGLGKEVLSRPFGWYLMPINVIFRLIDEGVKPISLALRLFGNLFAGELIFILIALLPWWSQFTLGMVWTLFHLLVITVQAFIFMMLTVVYISLAAESH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y930_LIGS1
Sequence: MNLWVTGYRSYELGVFNSKDKKVEVIKYALQKKILEKLDEGLEWVITGAQMGIEQWTCEVVAEMKKEYPELKLAIMMPYSEFAGNWNEANQESFSIRCSLADFVGEVSKEKYKSPMQLKNYQNFMLDHTDQAMLIYDPEHEGKTKYDYEMIKKYSEQEDYSYDLVDMYQLQEFAEMYQEKDSF
What are the official names of this protein?
UPF0398 protein LSL_0930.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: BHE41_MOUSE
Sequence: MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVSHLHAVATQLLTPQVPSGRGSGRAPCSAGAAAASGPERVARCVPVIQRTQPGTEPEHDTDTDSGYGGEAEQGRAAVKQEPPGDSSPAPKRPKLEARGALLGPEPALLGSLVALGGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIPAAAAAAAAAAFPCLSSVLSPPPEKAGATAGAPFLAHEVAPPGPLRPQHAHSRTHLPRAVNPESSQEDATQPAKDAP
What is the function of this protein?
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes.  Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop).  Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2.  Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes.  Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2.  Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.  Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544).
What are the official names of this protein?
Class E basic helix-loop-helix protein 41, bHLHe41, Class B basic helix-loop-helix protein 3, bHLHb3, Differentially expressed in chondrocytes protein 2, mDEC2.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYT11_RAT
Sequence: MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGSHRESGRGNLLVNAESGLLSHDRDPRGPSPASCIDQLPIKRDYGEELRSPMTSLTPGESKPTSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDGQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTTSGAEHWREVCESPRKPVAKWHSLSEY
What is the function of this protein?
Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (PubMed:9162066).  Inhibits clathrin-mediated and bulk endocytosis in neurons, functions to ensure precision in vesicle retrieval (PubMed:29311685, PubMed:26589353).  Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process (PubMed:29311685).  Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity.  In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis.  In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity).  Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (By similarity).
What are the official names of this protein?
Synaptotagmin-11, Synaptotagmin XI, SytXI.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass membrane protein. Perikaryon. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, phagosome. Cell projection, axon. Cell projection, dendrite. Postsynaptic density. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass membrane protein. Perikaryon. Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions. In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis.
Protein: NQRB_CHLFF
Sequence: MLKRFVNSIWEICQKDKFQRFTPVADAIDTFCYEPIHKSSSPPFIRDAVDVKRWMILVVVALFPATFSAIWNSGVQSLVYGSGNAQLMEAFLHISGFRSYLSFIFHDVGVFSVLWAGYKIFLPLLIISYSVGGACEVLFAVIRKHKIAEGLLVTGILYPLTLPPTIPYWMAALGIAFGVVVSKELFGGTGMNILNPALSGRAFLFFSFPAKMSGDVWVGSNPMKIKESLLAMNSTAGKSIIDGFSQSTCLHTLNSTPPSVKRVHVDAIASNILHMTHVPTQNVIQSQFSIWTESHPGLMLDKLTLEQLQSFVTSPLSEGGLGLLPTQFDSAYAITDVIYGIGKFSSGNLFWGNIVGSLGETSTFACLLGAIFLIVTGIASWRTMVSFGIGAFVTAWLFKIVSILIVGKHGAWAPARFFIPAYRQLFLGGLAFGLVFMATDPVSSPTMKLAKWIYGLFIGFMTILIRLINPAYPEGVMLAILLGNVFAPLLDYFAVRKYRRRRI
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit B, Na(+)-NQR subunit B, Na(+)-translocating NQR subunit B, NQR complex subunit B, NQR-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MMP13_HUMAN
Sequence: MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
What is the function of this protein?
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN.  Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen.  Can also degrade collagen type IV, type XIV and type X.  May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2.  Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification.  Required for normal embryonic bone development and ossification.  Plays a role in the healing of bone fractures via endochondral ossification.  Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2.  Plays a role in keratinocyte migration during wound healing.  May play a role in cell migration and in tumor cell invasion.
What are the official names of this protein?
Collagenase 3, Matrix metalloproteinase-13, MMP-13.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: NRN1L_MOUSE
Sequence: MMCNCCHCHWRRRCQRLPCALTLLLLLPLAVASEGPNRCDTIYQGFAECLIRLGDGMGRGGELQTVCRSWNDFHACASRVLSGCPEEAAAVWESLQQEARRAPHPDNLHILCGAPVSVRERIAGPETNQETLRATAPALAPAPAPVLLAAALALACLLGPLA
What are the official names of this protein?
Neuritin-like protein, Candidate plasticity gene 15-2 protein.
What is the protein family that this protein belongs to?
Belongs to the neuritin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.