PharMolix/UniProtQA huggingface dataset:
Protein: UL33_HHV7J
Sequence: MICYSFAKNVTFAFLIILQNFFSQHDEEYKYNYTCITPTVRKAQRLESVINGIMLTLILPVSTVVICTLLIYYKWTKQTITSPYLITLFISDSLHSLTVLLLTLNREALTNLNQALCQCVLFVYSASCTYSLCMLAVISTIRYRTLQRRTLNDKNNNHIKRNVGILFLSSAMCAIPAVLYVQVEKKKGNYGKCNIHISTQKAYDLFIGIKIVYCFLWGIFPTVIFSYFYVIFGKTLRALTQSKHNKTLSFISLLILSFLCIQIPNLLVMSVEIFFLYIANTSCLGTIQREIVQIISRLMPEIHCLSNPLVYAFTRTDFRLRFYDFIKCNLCNSSLKRKRNPLTIKN
What are the official names of this protein?
G-protein coupled receptor homolog U12.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein.
Protein: DAND5_HUMAN
Sequence: MLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSWKAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQVFSRPGCSAIRLRNHLCFGHCSSLYIPGSDPTPLVLCNSCMPARKRWAPVVLWCLTGSSASRRRVKISTMLIEGCHCSPKA
What is the function of this protein?
Seems to play a role in the correct specification of the left-right axis.  May antagonize NODAL and BMP4 signaling.  Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).
What are the official names of this protein?
DAN domain family member 5, Cerberus-like protein 2, Cerl-2, Cysteine knot superfamily 1, BMP antagonist 3, Gremlin-3.
What is the protein family that this protein belongs to?
Belongs to the DAN family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRF_STRT1
Sequence: MRENRPVIALDFPTLEDVKAFLAKFPADEKLYVKIGMELYYAAGPEIVRYVKELGHSVFLDLKLHDIPNTVKSAMRVLSNLGVDMTNVHAAGGVEMMKAAREGLGEGPILIAVTQLTSTSEEQMRDFQNIQTTLQESVVHYAQKTAEAGLNGVVCSAHEVAKIKEATNQDFVCLTPGIRPAGAAVGDQKRVMTPDDAHQIGSDYIVVGRPITQAEDPVAAYHDIKAQWNDQ
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: BABA1_HUMAN
Sequence: MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLAHPLQRPCQSHASYSLLEEEDEAIEVEATV
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665).  In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665).  Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985).  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).
What are the official names of this protein?
BRISC and BRCA1-A complex member 1, Mediator of RAP80 interactions and targeting subunit of 40 kDa, New component of the BRCA1-A complex.
What is the protein family that this protein belongs to?
Belongs to the BABAM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: HYPA_LEGPH
Sequence: MHELWLCKRIVEIIKQQATGNKCRKVKKIVLEIGQLVAVDKHALNFSFKVITQGTIAQNAELSIVEIPGEAICNSCQQIVPMKQYYDECLVCGNHSLTLTKGEELKVKSMVVE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: SPIR1_MACFA
Sequence: MANTVEADGSNDEGYEAAEEGPEDEEDEKREISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLAKVKSAKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESTKNLMESSMVNGGLTSQTKENGLSSAEQVPAQRKKLLKAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSPPGPSEYCPSERTISEI
What is the function of this protein?
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament.  Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport.  Required for asymmetric spindle positioning and asymmetric cell division during meiosis.  Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.  Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage.  In addition, promotes innate immune signaling downstream of dsRNA sensing.  Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1.
What are the official names of this protein?
Protein spire homolog 1.
What is the protein family that this protein belongs to?
Belongs to the spire family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cleavage furrow. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Punctate spots in perinuclear region and cytoplasm, co-localized with Rab11. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.
Protein: RF3_HAHCH
Sequence: MGLREEIKRRRTFAIISHPDAGKTTITEKVLLHGGALQKAGTVKGKKSGQFAKSDWMEMEKERGISVTTSVMQFPYDDSLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDSAKGVEERTIKLMEVTRLRDTPIITFMNKLDRDIRDPMELLDEVEDVLKIKCAPISWPIGMGKGFKGVYHLLRDEVILYQTGKGHTLQDGRTIKGLDNPELDQVLGSDAENLRGEIELLQGASHEFDHQAFLAGELTPVFFGTALGNFGVDHMLDGLVAWAPSPQPRETDKRMVEAEDEKFSGFVFKIQANMDPLHRDRIAFLRVCSGRYEQGMKIKHVRLGKDIRIADALTFMAGDRARAEEAFAGDIIGLHNHGTIQIGDTFSEGEELKFSGIPNFAPELFRRIRLKDPLKSKQLQKGLIQLSEEGAVQVFRPLNNNDLIVGAVGMLQFDVVVHRLKSEYKVEAVYEPVNVSTARWVDAKDPKKLEEFKRKVSENLSLDGGDNLTYLAPTNVNLQLAIERYPDVQFRKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARCA_MARMS
Sequence: MIEFGVHSEVGKLRKVIVCRPGLAHSRLTPGNAAQLLYDDVLWVQQARTDHMDFCMKMESRGIKVLEFGQLLEETVRDKGARNWILDRRINENQVGVGMLNELRSWLDDMSAEQLAIYLIGGISVHELPFKPHGMFGNYLGGDGFVIPPLPNTQFPRDNSSWIYNGVTVNPMFWPARRPETLLVTAVYRFHPEFAPAFNNGDFKIWWGDPDLDHGPATAEGGDVMAWGNGSVLIGMGERTSPQAVGQIAKRLFEQGAATRVIACQMPRSRSAMHLDTVFSHCDRDVVTAFTDVCDEIQCYTLRPGDHAGQIDFRKEKKHLFQLAADCLGIKKLNVVQTGGDHYQKEREQWDDGNNVIALEPGVVVAYDRNTYTNTLLRKAGVEVITVSGAELGRGRGGGHCMTCPVWRDPVSY
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_DESDA
Sequence: MAVTKEEVVEFISNMTVLELSEFIKELEEKFGVSAAAPAAAMMVAAPAAGGAADAAEEKTEFDVILKEAGANKIGVIKVVRALTSLGLKEAKEKVDGCPSTLKEAVSKEEAEDAKKQLTEAGAVVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PG087_VAR67
Sequence: MPFRDLILFNLSKFLLTEDKESLEIVSSLCRGFEISYDDLITYFPDRKYHKYIYKVFEHVDLSEELSMEFHDTTLRDLVYLKLYKYSKCIRPCYKLGDNLKGIVVIKDRNIYIREANDDLIEYLLKEYTPQIYTYSNEHVPIAGSKLILCGFSQVTFMAYTTSHITTNKKVDVLVSKKCIDKLVDPINYQILQNLFDKGSGTINKILRKIFYSVTGGQTP
What is the function of this protein?
Involved in postreplicative transcription elongation on intermediate and late genes.
What are the official names of this protein?
Late transcription elongation factor OPG087, Late transcription elongation factor G2, Protein G2.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG087 family.
Protein: FER_SOLNI
Sequence: ATYKVKLVTPDGPIEFDCPDDVYILDQAEEEGHELPYSCRAGSCSSCAGKVTAGTVDQSDGNFLDDDQMADGFVLTCVAYPKSDVTIETHKEEDLTG
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SFSA_CHLSY
Sequence: MVTGHGTGHHGQSPVRVPLSSGAPLVEATFASRPSQFLVEAQMGGRMVRAHLADRGRLTDLLTPGARLLLASREEIGRKTAFQVVAVYQDGDLVSLDTQLPNRLVAAALSLGALPQFARYSRVQREVQLGPHRIDFRLSEGLDTCLLEVKSVTRLVDGIAVFPDAPTERGGRHLELLINAARNGQRAAVVFIIQRSRGCAFAPDVTVDPAFSRSLREARSVGVEIYAYRCPVDPSGITLGQEVPVFASFAAVPFELRQH
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: NACB_ASPFU
Sequence: MDQAKLARMQASVRIGTFCSFLWIFEVLESESVFSADGFQAHHLGNVIGKGTPRRKVKKVHKSSGADDKKLQTTLKKMNVQPIQAIEEVNMFKEDGNVIHFAAPKVHASVPSNTFALYGNGEEKELTELVPGILNQLGPDSLASLRKLAESYQNMQKQAGAEGKKDEDEDDIPDLVEGENFESNVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: SGK3_MOUSE
Sequence: MQRDCIMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNSLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPRHQSDPSEDEDERSTSKPHSTSRNINLGPTGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKNRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
What is the function of this protein?
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration.  Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1. 3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.  Plays a role in the regulation of renal tubular phosphate transport and bone density.  Phosphorylates NEDD4L and GSK3B.  Positively regulates ER transcription activity through phosphorylation of FLII.  Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
What are the official names of this protein?
Serine/threonine-protein kinase Sgk3, Cytokine-independent survival kinase, Serum/glucocorticoid-regulated kinase 3, Serum/glucocorticoid-regulated kinase-like.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Colocalizes with SLC9A3/NHE3 in the recycling endosomes (By similarity). Localized in vesicle-like structures and in the early endosome.
Protein: HSLO_PECAS
Sequence: MAHDQLHRYLFENYAVRGELVTVNETYQRILTNHDYPAAVQTLLGEMLVATSLLTATLKFSGDITVQLQGDGPLKLAVINGNHLQQMRGVARLQGDIAPGSSLKEMVGNGYLVITITPTDGERYQGVVGLEGETVAECLESYFQQSEQLPTRLFIRTGQHEGNPVAAGMLLQVLPAQDAERNDFDHLAQLTATVKAEELFTLPANEVLYRLYHQEEVTVYEPQDVEFQCHCSRDRCANALMTLSDQEINEMIEQDGEIDMHCDYCGTHYLFNSLDIRAIRHDSSGNLLH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBK1_DEBHA
Sequence: MNYDYLTDEQKQQLYFHQMQAEQQQHQQQLHYKQQQHIQQQQQHQQNQQNQQQQPQPPRQPFSTFLQNNGSNSDLPQMGTFQQDLQRQNIPNLRFSQQNQPSDLGQEFQDDDSFMDEDLTEIHEQPPMQELNSSPMTHPHSFQQNFQTPTKNDDANLRNQQFQSVDSERSLDFKPPVTFTKLNNNSNADLSSPTESSFLKSNLNLPNSNIPPAGASNDPNAQKSNYIYFNRQPNSLNKIAQDKASSIKLKLENYYQMSVAHAIERNQRRLDLEHKLLNEESGSSEERKNRQLQNLGKKESQFLRLRRTKLSLEDFNTVKVIGKGAFGEVRLVQKRDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDITRFYMAECVLAIEAIHKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLEKENPHHTNPQNGNLQAPSMATNNRNSMMVDAIHLTMSNRQQMQTWRKSRRLMAYSTVGTPDYIAPEIFVHQGYGQECDWWSLGAIMFECLIGWPPFCSETPHETYRKILNWQETLQIPDDIHLSPESEDLIRKLLTNAENRLGRYNGADELKSHPFFRGVDWDTIRKVDAPFIPKLRSITDTRFFPTDELENVPDSPALSKAMEQRDQVLQNGGNVKEDLPFIGYTYSRFDYLTRKNAL
What is the function of this protein?
Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.
What are the official names of this protein?
Serine/threonine-protein kinase CBK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.
Protein: SASA_SYNJA
Sequence: MQTSLDRTSTRSGIRLLLFAQGRANIEELAEQLRRHIQGLPGQHPAHLKVVPLEEHPYLAEHYKLVVTPALVKAEPLPAQVLAGEDLATQLEVWWPRWQGQAALVSYQEEAGQDPAPPPTTEALLQMSEEVFSLRQERAQLREQLDFKDRVLAMLVHDLRSPLTATALAVETLQQGREGSLDKAVERQLFEHARQQLRKMDSMITDILESARGSASELRIRAVETQLASLCQPVIEELLPRIQAKQLQFQADIPVDLPTVHVDPDKIRQVIFNLLDNAIKYTPAGGSIRLNILHRTSQKVQVTVSDTGPGIPEAEQENIFSDAVRLSRDQQQEGYGIGLSLCRRIVRAHYGQIWVESILGKGSSFHFTLPVYRLCGR
What is the function of this protein?
Member of the two-component regulatory system SasA/RpaA involved in genome-wide circadian gene expression.  One of several clock output pathways.  Participates in the Kai clock protein complex, the main circadian regulator in cyanobacteria, via its interaction with KaiC.  KaiC enhances the autophosphorylation activity of SasA, which then transfers its phosphate group to RpaA to activate it.  In addition to its output function, recruits fold-shifted KaiB (KaiB(fs)) to KaiC to cooperatively form the KaiB(6):KaiC(6) complex (independent of SasA kinase activity).  Required for robustness of the circadian rhythm of gene expression and is involved in clock output, also required for adaptation to light/dark cycles.
What are the official names of this protein?
Adaptive-response sensory kinase SasA, Sensor histidine kinase SasA.
Protein: PEPA_NEOFI
Sequence: MVVFSKVTAVVVGLSTIVSAVPVVQPRKGFTINQVARPVTNKKTVNLPAVYANALTKYGGTVPDSVKAAASSGSAVTTPEQYDSEYLTPVKVGGTTLNLDFDTGSADLWVFSSELSASESSGHAIYKPSANAQKLNGYTWKIQYGDGSGASGDVYKDTVTVGGVTAQSQAVEAASQISSQFVQDKDNDGLLGLAFSSLNTVSPRPQTTFFDTVKSQLDSPLFAVTLKYHAPGTYDFGYIDNSKFQGKLTYADVDNSQGFWMFTADGYGVGDGAPNSNHISGIADTGTTLLLLDDSVVADYYHQVSGAKNSNEYGGYVFPCSTKLPSFTTVIGGYNAVVPGEYINYAPVTDGSSTCFGGIQSNSGLGFSIFGDVFLKSQYVVFDSQGPRLGFAPQA
What is the function of this protein?
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates.  The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site.  Shows a broad primary substrate specificity.  Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A.
What are the official names of this protein?
Aspergillopepsin-1, Aspartic protease pepA, Aspergillopepsin I, Aspergillopeptidase A.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAZ_YERPP
Sequence: MFRGATMVNLDSKGRLAVPTRYRESLNEESQGQMVCTIDLHQPCLLLYPLPEWEIIEQKLSRLSSMNPAERRVQRLLLGHASECQMDGAGRLLIAGTLRQHAGLNKEVMLVGQFNKFELWDEQTWYQQVKDDIDAEQSTQEPLSERLQGLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: HRCA_BACHK
Sequence: MLTERQLLILQTIIDDFIGSAQPVGSRTLAKKDEITYSSATIRNEMADLEELGFIEKTHSSSGRVPSEKGYRFYVDHLLAPQNLPNDEIVQIKDLFAERIFEAEKIAQQSAQILSELTNYTAIVLGPKLSTNKLKNVQIVPLDRQTAVAIIVTDTGHVQSKTITVPESVDLSDLEKMVNILNEKLSGVPMSELHNKIFKEIVTVLRGYVHNYDSAIKMLDGTFQVPLSEKIYFGGKANMLSQPEFHDIHKVRSLLTMIDNEAEFYDILRHKQVGIQVKIGRENSATAMEDCSLISATYSIGEEQLGTIAILGPTRMQYSRVISLLQLFTRQFTDGLKK
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: TPIS_PSEPG
Sequence: MRRPMVAGNWKMHGTRASVAELTEGLSNLALPSGVEVAVFPPALFINQVIDGLAGKEITVGAQNSAVQPEQGALTGEVAPEQLVEAGCKLVLIGHSERRQVIGETDEVLNRKFAAAQAKGLKPVLCIGETLEEREAGKTLEVVGRQLSSIIEAFGVKAFANAVIAYEPVWAIGTGLTATPQQAQDVHAAIRGQLAAEDAEVAAKVQLLYGGSVKAANAAELFGMPDIDGGLIGGASLNADEFGAICRAAGN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_PSEA7
Sequence: MTFAAAQATYVLHSRPYKETSALVDFFTAQGRLRAVLRGARGKAGALARPFVPLEAEWRGRGELKTVARLESAGIPNLLSGQALFSGLYLNELLIRLLPAEDPQPEIFAHYAATLPLLAAGRPLEPLLRAFEWRLLEQLGYGFALDVDIHGRPIEPQALYQLLPEAGLEPVTQLQPGLFQGVELLSMADADWSAPGALAAAKRLMRQALAPHLGGRPLVSRELFMNRKESPRD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: NUOI_METCA
Sequence: MISQLRTLWIVLKHTFSRADTVQYPEQRPKLYPRYRGRIVLTRDPDGEERCVACNLCAAVCPVDCIALQKTEDVDGRWYPEFFRINFSRCILCGLCEEACPTYAIQLTPDFELCEYDRRNLVYEKEHLLIQGTGKYPGYSFYRVAGKAIAGKDKGQAENEAPPIDVHSLLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CUG6A_CONCL
Sequence: NCPAGCRSQGCCM
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).  Reversibly blocks calcium current in the dorsal-root ganglion neurons of the rat (high voltage-activated channels but not low voltage-activated channels).  Does not modify the voltage dependency of activation and inactivation.
What are the official names of this protein?
Omega-conotoxin Cl16a, Conotoxin CalTx, Omega-conotoxin Cl15a.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMC_YERPE
Sequence: MSALTPASEVILRHSDEFIARHVLFAGDLQDALPAQFDAAGVRVHTNQYHHWQLLSNTLEENVQFGLLATAETLAACDTLIYYWPKSKQEAQFQLANLLSILPVGTDIFVVGENRSGVRSAEEMLADFAQLAKIDSARRCGLYHGRLDKQPEFDADAWWESYQVGGVTVKTLPGVFSRDSLDSGSHLLLSTFNEPFKGSVLDVGCGAGVLASVLAQQSPKIKWTLSDVSAAAIEASRATLAVNNIEAQVIASNVYSDIKGRFEMIISNPPFHDGIQTSLTAAEMLIRGATAHLHVGGKLRIVANSFLPYPALLDAAFGSHEVLAQNGRFKVYQATVGRPPRDPKKKR
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.