PharMolix/UniProtQA huggingface dataset:
Protein: Y1247_HELPY
Sequence: MYRKDLDHYLKQRLPKAVFLYGEFDFFIHYYIQTISALFKCDNPDIETSLFYASDYEKSQIATLLEQDSLFGGSSLVVLKLDFALHKKFKENDINLFLKALERPSHNRLIIGLYNAKSDTTKYKYTSDAIVKFFQKSPLKDEAICARFFIPKTWESLKFLQERANFLHLDISGHLLNALFEINNEDLGVSFNDLDKLAVLNAPITLEDIQELSSNAGDMDLQKLILGLFLKKSALDIYDYLLKEGKKDADILRGLERYFYQLFLFFAHIKTTGLMDAKEVLGYAPPKEIAENYAKNALRLKEAGYKRVFEIFRLWHIQSMQGQKELGFLYLTSIQKIINP
What is the function of this protein?
Could be the functional equivalent of DNA polymerase III delta subunit (HolA).
What are the official names of this protein?
Protein HP_1247.
Protein: MIAA_CHLAB
Sequence: MRAPEFHANAMTSTGCDVCLDPQKSFAKLFKRTVILLAGPTGSGKTDVSLRLAPMIDGEIISVDSMQVYRGMDIGTAKVSWEDRQRIPHYLIDICHVQELFNAVDFYYQAIQACQNILSRNKVPILVGGTGFYFHTFLSGPPQGPSPDCDFRDKLALYIQEHGLSLLYENLCLKDPEYARTITKNDRNKIVRALEIIHLTGKKVSDHKWTKEASECQEYNCRGWFLSPPKELLRDTIHLRCQRMLEDDLIDEVHRLLKQGIRDNSSASRAIGYREWIEFIDQGSPAESYEAVKQKFITNTCHYTKKQRTWFKRYPIFRELPTLGLTAETIAAKIAEDYFLHG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: FAA26_MYCBO
Sequence: MPVTDRSVPSLLQERADQQPDSTAYTYIDYGSDPKGFADSLTWSQVYSRACIIAEELKLCGLPGDRVAVLAPQGLEYVLAFLGALQAGFIAVPLSTPQYGIHDDRVSAVLQDSKPVAILTTSSVVGDVTKYAASHDGQPAPVVVEVDLLDLDSPRQMPAFSRQHTGAAYLQYTSGSTRTPAGVIVSHTNVIANVTQSMYGYFGDPAKIPTGTVVSWLPLYHDMGLILGICAPLVARRRAVLMSPMSFLRRPARWMQLLATSGRCFSAAPNFAFELAVRRTSDQDMAGLDLRDVVGIVSGSERIHVATVRRFIERFAPYNLSPTAIRPSYGLAEATLYVAAPEAGAAPKTVRFDYEQLTAGQARPCGTDGSVGTELISYGSPDPSSVRIVNPETMVENPPGVVGEIWVHGDHVTMGYWQKPKQTAQVFDAKLVDPAPAAPEGPWLRTGDLGVISDGELFIMGRIKDLLIVDGRNHYPDDIEATIQEITGGRAAAIAVPDDITEQLVAIIEFKRRGSTAEEVMLKLRSVKREVTSAISKSHSLRVADLVLVSPGSIPITTSGKIRRSACVERYRSDGFKRLDVAV
What is the function of this protein?
Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension.  Catalyzes the adenylation of the long-chain fatty acids eicosanoate (C20) or docosanoate (C22), and potentially the very-long-chain fatty acid lignocerate (C24).  Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B).
What are the official names of this protein?
Long-chain-fatty-acid--AMP ligase FadD26, FAAL, Acyl-AMP synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CLUL1_MOUSE
Sequence: MQPPLLVLSVYLLWLKYCDSAPTWKETDATDGNLKSLPEVGEADVEGEVKKALIGIKQMKIMMERREEEHAKLMKALKKCKEEKQEAQKLMNEVQERLEEEEKLCQASSIGSWDGCRPCLESNCIRFYTACQPGWSSVKSMMKQFLKKIYRFLSSQSEDVKDPPAIEQLTKEDLQVVHIENLFSQLAVDAKSLFNMSFYIFKQMQHEFDQAFQLYFMSDVDLMEPYPPALSKEITKKEELGQRWGIPNVFQLFHNFSLSVYGRVQQIIMKTLNAIEDSWEPHKELDQRGMTSEMLPEQNGEMCEEFVKNLSGCLKFRKRCQKCHNYLSEECPDVPELHIEFLEALKLVNVSNQQYDQIVQMTQYHLEDTIYLMEKMQEQFGWVSQLASHNPVTEDIFNSTKAVPKIHGGDSSKQDEIMVDSSSILPSSNFTVQNPPEEGAESSSTIYYIVAKVLQHFKGHFKTW
What are the official names of this protein?
Clusterin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the clusterin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBL_POPTM
Sequence: MSPQTETKTGVGFKAGVKEYKLNYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEENQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYTKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEALYKAQTETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDFVEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKEIKFEFEAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL4_NOVAD
Sequence: MKVQVLNLDGTAGKGEVELSDDVFGLEPRADILHRVVTWQLENRRGIARKARERSDVARTGKKFGRQKGGGTARHGDRKAPIFIGGGKAHGPRVREFNISLNKKVRALGLKMALSSKAKAGLVVVDNLDVDAKTKALVGQLAKANWGKKVLVIDGEGVNDNFAKAARNIVGVNVLPAIGANVYDILKHDTLVLTRAAVEKLEARFNG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PAOA_ECO57
Sequence: MSNQGEYPEDNRVGKHEPHDLSLTRRDLIKVSAATAAAAVVYPHSTLAASVPAATPAPEIMPLTLKVNGKTEQLEVDTRTTLLDALRENLHLIGTKKGCDHGQCGACTVLVNGRRLNACLTLAVMHQGAEITTIEGLGSPDNLHPMQAAFIKHDGFQCGYCTSGQICSSVAVLKEIQDGIPSHVTVDLVSPPERTADEIRERMSGNICRCGAYANILAAIEDAAGEIKS
What is the function of this protein?
Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes.  It might play a role in the detoxification of aldehydes to avoid cell damage.
What are the official names of this protein?
Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA.
What are the subcellular locations of this protein?
Periplasm.
Protein: MDTL_CITK8
Sequence: MTRFLICSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKVADQSGRKPVAIAGAVIFIIASMLCSRATDGSLFLTGRFIQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIVPVLAPVLGHLIMLKFPWQSLFYTMIAMGIAVCLLSVFILKETRPATCSSTSRPQQNAESLLNRFFLSRLAITTLSVSVILTFVNTSPVLLMEMMGFDRGEYATTMALTAGISMAVSFSTPFALSVFKPRTLMLTSQGLFLAAGIVLSLSSSHAVTLFGLTLICAGFSVGFGVAMSQALGPFSLRAGVASSVLGIAQVCGSSLWIWLAAVIGFNALNMLIGILIGCSMVCILLLMTIQPAAHYEKIHHQSRS
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y338_BDEBA
Sequence: MPSFDIVSEIDVQEVDNAVNQARKEIEARYDFKGSKAELQWDKKEMVLLAEDDYKIGAMAGILQTKLHRRGIDIKAIKFEKIEEAGGRMLRQKVTLVQGIDREIAKDIIKLIKDSKLKVQPQVADDKLKVTSKSIDELQECISLVRGGNFPLPLQFNNMRA
What are the official names of this protein?
UPF0234 protein Bd0338.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: TUSC_ECOLU
Sequence: MKRIAFVFSTAPHGTAAGREGLDALLATSALTDDLAVFFIADGVFQLLQGQKPDAVLARDYIATFKLLGLYDIEQCWVCAASLRERGLDPQTPFVVEATPLEADALRRELANYDVILRF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_AGRFC
Sequence: MPTVNQLIRKPRQAQVKRNKVPALQENPQKRGVCTRVYTTTPKKPNSALRKVAKIRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: YEFM_STRCO
Sequence: MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNARRLLDSIAEAEAGDATEHDLIDPDAERA
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  A probable antitoxin for the putative mRNA interferase YeoB (By similarity).
What are the official names of this protein?
Antitoxin YefM, ORFU1E.
What is the protein family that this protein belongs to?
Belongs to the phD/YefM antitoxin family.
Protein: DEF_ECOHS
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: PURL_BARHE
Sequence: MKPCNNIAITPELIAQHGLKNDEYQHILTLIGREPTFTELGIFSAMWNEHCSYKSSKKWLKTLPTKGNCVIQGPGENAGVVDIGEGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGSPDHPRTRYLVAGVVSGIGGYSNAFGVPTVGGEINFDERYNGNILVNAFVAGIAKKDSIFYSKAQGVGLPVVYLGAKTGRDGVGGATMASAEFDDSISEKRPTVQVGDPFTEKCLLEACLELMELGAVVAIQDMGAAGLTSSAVEMGAKGDLGIKLNLDKVPVREENMTAYEMMLSESQERMLMVLKPELEKQASAIFHKWGLHFSIIGQTTDDLRFRVLHQGEEVVNLPIKELGNEAPVYDRPWSEPTPQPILKVEEVKKVENLGDVLLTLLNSAHQSSRRWVYEQYDTLIQGNTLVRPGADAGVIRVSSNDKRALAFSSDVTPRYCEADPYEGGKQAVAECWRNISTTGAMPLAATDNLNFGNPEKPEIMGQLVLAIKGIGEACRVLDFPIVSGNVSLYNETNGEAILPTPTIAGVGLLDDWSKMVTISGMQNGDSIVLIGDCGSHLGQSIYARNVLNINTGAPPHVDLQLEKKHGQFVRDVIHRGFVHAAHDISDGGLAIALAEMVIKAKKGIKAKLSNRLPHHAELFGEDQGRYLLSIKPYVLNHLKELAQVNAVSLTEIGRVEGNSLNIEGILTLSVDKLTQAYESWFPQFMGE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_STRA5
Sequence: MAVKIRLTRMGSKKKPFYRINVADSRAPRDGRFIETVGTYNPLVAENQVTIKEERVLEWLSKGAQPSDTVRNLLSKAGVMTKFHDQKFSK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: WOX6_ORYSJ
Sequence: MEGSSNSPDRQSSGGSPPEERGGGGSGGGGGRSAAGEPVRSRWTPKPEQILILESIFNSGMVNPPKDETVRIRKLLERFGAVGDANVFYWFQNRRSRSRRRQRQMQAAAAAAAAAASSSSPSANTSPAAASAATVQVGLPPGAVVHTMAMGGSACQYEQQASSSSSSGSTGGSSLGLFAHGAGASGAGGYLQASCGASASASSALAPGLMGDVVDSGGSDDLFAISRQMGFVGSPRCSPASSPATPSSAATAAQQQFYSCQLPAATITVFINGVPMEMPRGPIDLRAMFGQDVMLVHSTGALLPVNDYGILMQSLQIGESYFLVARPP
What is the function of this protein?
Transcription factor which may be involved in developmental processes.
What are the official names of this protein?
WUSCHEL-related homeobox 6, OsWOX6.
What is the protein family that this protein belongs to?
Belongs to the WUS homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AN13A_HUMAN
Sequence: MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLCPSALSETSRFDNDLQLAMELSAKELEEWELRLQEEEAELQQVLQLSLTDK
What is the function of this protein?
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin.  Does not bind 'Lys-48'-linked ubiquitin.  Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 13A, Protein KE03.
What are the subcellular locations of this protein?
Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
Protein: DMA7_ECOLX
Sequence: MSTILKWAGNKTAIMSELKKHLPAGPRLVEPFAGSCAVMMATDYPSYLVADINPDLINLYKKIAADCEAFISRARVLFEIANREVAYYNIRQEFNYSTEITDFMKAVYFLYLNRHGYRGLCRYNKSGHFNIPYGNYKNPYFPEKEIRKFAEKAQRATFICASFDETLAMLQVGDVVYCDPPYDGTFSGYHTDGFTEDDQYHLASVLEYRSSEGHPVIVSNSDTSLIRSLYRNFTHHYIKAKRSIGVSAGESKSATEIIAVSGARCWVGFDPSRGVDSSAVYEVRV
What is the function of this protein?
An alpha subtype methylase that recognizes the double-stranded sequence 5'-GATC-3' and methylates A-2 on both strands.  May play a regulatory role in the functions of the retron.
What are the official names of this protein?
Retron Ec67 DNA adenine methylase, M.Eco67Dam, ORF1-Ec67 dam, Orphan methyltransferase M.EcoEc67Dam, M.EcoEc67Dam.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: MRAY_AFIC5
Sequence: MFYWLTELAGTIPGINVFRYITFRTGGAMVTGALFVFLFGPWIIDHLRLAQGKGQPIRADGPPTHLMTKKGTPTMGGLMILSGLVVSTLLWANLHNPYVWVVLMVTLGFGFVGFYDDYLKVTKQTHAGFSGRLRLAVEGLIALFACLVIIWAGRDSSVMHLGIPFAKDFAINLGWFYLVFGAFIIVGAGNAVNLTDGLDGLAIVPVMIAAASFGMIAYLVGNAVFSEYLQIRYVAGTGELAVLCGAVLGAGLGFLWFNAPPASIFMGDTGSLALGGMIGSIAVAVKHEIVLAVIGGLFVFEALSVIVQVASFKLTGKRIFRMAPIHHHYEQKGWTEPQIVIRFWIIAVMLALAGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EX7L_SALTI
Sequence: MLSSQTSSIFTVSRLNQTVRLLLEQEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIAESMQPAGEGLLQQKYEQLKAKLHAEGLFDQQHKQPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANTRGECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEIVSRNQQELLRQIQSAQQRLGMAMDYYLANRSRRFTQIFHRLQQQHPQLRLARQQTALERLRQRMGFALEARIKQATQRQQRVSQRLSQQNPQPRIHRVQSRIQQLEYRLTENIRSRLSEQRERFGNAVTHLEAVSPLATLARGYTVSTTTDGKVLKKIKQVKAGDIMTTRLEDGWLESEVKSVTPGT
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNAS1_MUSPA
Sequence: MGLEKSLILFPLFVLLLGWVQPSLGKESSAQKFERQHMDSSGSSNNSPTYCNQMMKSRSMTKESCKPVNTFVHEPLEDVQAICSQENVTCKNGNRNCYKSSSALHITDCHLKGNSKYPNCNYNTNQYQKHIIVACDGNPYVPVHLDATV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: MCM5B_XENLA
Sequence: MSGFDDLGIYYSDSFGGEQPVGDDGQAKKSQLKKRFREFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPTEHLQLLEEAAQEVADEVTRPRPAGEETIQEIQVMLRSDANPANIRNLKSEQMSHLVKIPGIIIAATAVRAKATKISIQCRSCRNTIGNIAVRPGLEGYAMPRKCNTEQAGRPKCPLDPYFIIPDKCKCVDFQTLKLQESPDAVPHGELPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIQKSGKTSTKGRDRVGVGIRSSYIRVVGIQVDTEGTGRSAAGTITPQEEEEFRRLAVKPDIYETVAKSIAPSIYGSTDIKKAIACLLFGGSRKRLPDGLTRRGDVNLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVMRDPVSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVYGRWDDTKGEENIDFMPTILSRFDMIFIVKDEHNEQRDMTLAKHVMNVHLSARTQSSSVEGEVDLNTLKKFIAYCRAKCGPRLSAEAAEKLKNRYILMRSGARDHERETEKRSSIPITVRQLEAVVRISESLGKMKLQPFVTETDVEEALRLFQVSTLDAAMSGSLSGVEGFSTQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIQDFLKQKYPEHAIHKVLNLMMRRGEIHHRLQRKVLYRLK
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
What are the official names of this protein?
DNA replication licensing factor mcm5-B, xMCM5-B, CDC46 homolog B, xCDC46-B.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: GSAP_HUMAN
Sequence: MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQFRIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMFEVPLDISLSNSGFKLVNFGCDYHQYRDKFSKHLTLCVFTNHTGSLCVCYSPKCASWGQITYSVFYIHKGHSKTFTTSLENVGSHMTKGITFLNLDYYVAVYLPGHFFHLLNVQHPDLICHNLFLTGNNEMIDMLPHCPLQSLSGSLVLDCCSGKLYRALLSQSSLLQLLQNTCLDCEKMAALHCALYCGQGAQFLEAQIIQWISENVSACHSFDLIQEFIIASSYWSVYSETSNMDKLLPHSSVLTWNTEIPGITLVTEDIALPLMKVLSFKGYWEKLNSNLEYVKYAKPHFHYNNSVVRREWHNLISEEKTGKRRSAAYVRNILDNAVKVISNLEARNLGPRLTPLLQEEDSHQRLLMGLMVSELKDHFLRHLQGVEKKKIEQMVLDYISKLLDLICHIVETNWRKHNLHSWVLHFNSRGSAAEFAVFHIMTRILEATNSLFLPLPPGFHTLHTILGVQCLPLHNLLHCIDSGVLLLTETAVIRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPMSSNIISRNHVTRLLQNYKKQPRNSMINKSSFSVEFLPLNYFIEILTDIESSNQALYPFEGHDNVDAEFVEEAALKHTAMLLGL
What is the function of this protein?
Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch.  The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
What are the official names of this protein?
Gamma-secretase-activating protein, GSAP, Protein pigeon homolog.
What is the protein family that this protein belongs to?
Belongs to the GSAP family.
Protein: EI2BD_SCHPO
Sequence: MGFSAEQAKKDGKDQSPVSESSSVGGTSPATASSVVSPNEPKLSGKEAKALKKARKQASRRAKAEAAAANNPPGVSEEKKVAIPNKNSNQQKKASKQNPQNSPETDANLQEKKIFEEKQVSIFSHLDWRRRRTTENIPKDIHPAVIRLGLKLANYKIFGSNQRCIDLLKTFKIVIQDYQTPYGTTLSRHLTTHINSQIAYLVSTRPLSISMGNAIRFLKLEISVLDIDLTDDEGKELLLEKIDSYIRDRIIIAGQVIVQAATEKIQDGDVILTYLHSSTVNDVLIHAKNVGKKFRVVVVDSRPEFEGRVCLKLLTEHGIECTYVMISALSYIMQEVTKIFLGGHAMLSNGALYSRAGTSLISLLGHESNVPVIACCESYKFTERIQLDSLVYNELAPGDQLVNMGVDDFEEKPGVLANWKSVKNLKLLSLKYDVTPPRLITVCVCEMGLLPSTSVPAIINEFKQVYA
What is the function of this protein?
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
What are the official names of this protein?
Probable translation initiation factor eIF-2B subunit delta, eIF-2B GDP-GTP exchange factor subunit delta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family.
Protein: ACBP4_ARATH
Sequence: MAMPRATSGPAYPERFYAAASYVGLDGSDSSAKNVISKFPDDTALLLYALYQQATVGPCNTPKPSAWRPVEQSKWKSWQGLGTMPSIEAMRLFVKILEEDDPGWYSRASNDIPDPVVDVQINRAKDEPVVENGSTFSETKTISTENGRLAETQDKDVVSEDSNTVSVYNQWTAPQTSGQRPKARYEHGAAVIQDKMYIYGGNHNGRYLGDLHVLDLKSWTWSRVETKVATESQETSTPTLLAPCAGHSLIAWDNKLLSIGGHTKDPSESMQVKVFDPHTITWSMLKTYGKPPVSRGGQSVTMVGKTLVIFGGQDAKRSLLNDLHILDLDTMTWDEIDAVGVSPSPRSDHAAAVHAERFLLIFGGGSHATCFDDLHVLDLQTMEWSRPAQQGDAPTPRAGHAGVTIGENWFIVGGGDNKSGASESVVLNMSTLAWSVVASVQGRVPLASEGLSLVVSSYNGEDVLVAFGGYNGRYNNEINLLKPSHKSTLQTKTLEAPLPGSLSAVNNATTRDIESEVEVSQEGRVREIVMDNVNPGSKVEGNSERIIATIKSEKEELEASLNKERMQTLQLRQELGEAELRNTDLYKELQSVRGQLAAEQSRCFKLEVDVAELRQKLQTLETLQKELELLQRQKAASEQAAMNAKRQGSGGVWGWLAGSPQEKDDDSP
What is the function of this protein?
Binds medium- and long-chain acyl-CoA esters with very high affinity.  Can interact in vitro with oleoyl-CoA, barely with palmitoyl-CoA, but not with arachidonyl-CoA.  May function as an intracellular carrier of acyl-CoA esters.  Plays a role in the biosynthesis of membrane lipids including galactolipids and phospholipids.
What are the official names of this protein?
Acyl-CoA-binding domain-containing protein 4, Acyl-CoA binding protein 4.
What is the protein family that this protein belongs to?
Belongs to the ACBP family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Also to the periphery of the nucleus.
Protein: RLMD_PSYCK
Sequence: MQPTDSKTLTNVDATEQANETQTITIPPNKKKSKPSSKTRRRLKDAEPLPFTIDGLSHDGRGVAVYGNGFGETDGHITDKHGKKIFVSFALPGESALVKITNSRTSFEEGDAVRITANPNPERVVPPCPHFGVCGGCNLQHWQPDAQITFKQSVLAEMLVHQANVAPDHWLEPVVGDRLGYRTKARLGVRYVVKKETALVGFRERSSNFLAELNECHILDPRIGFEIENLKTLISTLDSRDKIAQLELAMGEHLPELPDGDQPVALIVRNLEPLSDGDIDKLKVFFAARNWQLYLQSKGADSIQRIALRDTDDLSEQFGRLYYQLPEYDLTFEFIPTDFTQVNLSVNRQMTKLACDLLDLKAGERVLDLFSGLGNFSLPLARLVGETGSVVGVEGSEAMTARAADNARRNGINNTEFYSQDLTHDCTDKPWANQGFDALLIDPPRSGAWEIMQYLPKFNAERIVYVSCNPATLARDTKALLEQGYRLTHAGVMDMFCHTGHVESIARFEKISA
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.