PharMolix/UniProtQA huggingface dataset:
Protein: HEM3_ALKOO
Sequence: MKIRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIKELDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPKTVKEPDFSKPIGCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERISRIFEVTEILPAACQGVIVVQARKGFDVSFLSDFHDKEAWDISMAERSFVRTLNGGCSSPVAAYGEIKDNYLTLTGLYVDSSNSVHKKTITGARKQGEEMGFNLALQMKGEDEVHGKD
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: QUEA_CHLCH
Sequence: MQVADFDYHLPEERIAKYPPLERGSTRLLVLNRQSGALTHSLYAHLDTFLQAGDLLLLNNTRVVPARLFATRATGATIELMLLERHHHREQLVLYRGQLKAGEMLQSHGHTLLVEEVLPQGLARLALADGGDLHQFFTQFGSVPIPPYLKRNAEAVDRERYQTVFAAHSGSVAAPTASLNMTPELLQRLKNNGVEIAHITLHVGLGTFLPIRTESLEEHVMHRESYLLPAESVAALQRVKADGGRVVAVGTTVTRALEHSAPRILQSSAHAEIEGEADIFIYPGYRFQMVDLLLTNFHAPRSTVLMLTAACAGTDNLRAAYSEAVLQGYNFLSYGDSMLIC
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_CLOK1
Sequence: MRIFNTMTRRKEEFVPLIPGEIKMYVCGPTVYNFFHIGNARTFVVFDTVRRYFEYKGYKVNFVQNFTDIDDKMIKKANDENITVQQLGDRFIDEYYRDADALNIKRATVNPRATLYISKIIEFIQDLIDKGYAYSVDGDVYFNAKKFNNYGKLSGQNIEQLQSGARIDIDERKKNPMDFAVWKSEKKGEPSWESPWGMGRPGWHIECSCMAYNILGETIDIHAGGSDLKFPHHENEIAQSEGRTGKVFAKYWMHSAFVNINNQKMSKSLNNFFTTREILDKYEPDVIRLFMLSGHYRTPINFSIELLDSTKSALDRICNSIINLEELSSKVKNDGILDSEIKYKEHLNSYKQRYIEKMDDDFNTADAISVIFDLIRDINTNIDENSSMEIIKYSLALIRELGSPLGILQKSKRGSIETEVELLIEKRQKARKDKNWALADKIRDDLKDKGIILEDTSDGVRWKRV
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_AYWBP
Sequence: MFLEKEQDNLDNLKTQTKELHKDYTECQNCQKEETQTTNKDNQKEDETFKNQPNKTKQTNTKQQKHLSKESSHQQITKLQTQIKELQQKLSQQKKTFDEGLLKNQAEFINFKKRAQTQKENELKYASSNFINNLLMPLEQLEKVIDMPTQNELLQKYLLGFKLLQKQIKKVLQDEGVEEIEALNKPFDPTFHHALETVCDFEKPDKTNLAVLQKGYLYKKRILRPTLVKVNEWSDKNEKNE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMT1_CATRO
Sequence: MGSANPDNKNSMTKEEEEACLSAMRLASASVLPMVLKSAIELDLLELIKKSGPGAYVSPSELAAQLPTQNPDAPVMLDRILRLLASYSVLNCTLKDLPDGGIERLYSLAPVCKFLTKNEDGVSMAALLLMNQDKVLMESWYHLKDAVLEGGIPFNKAYGMTAFEYHGKDPRFNKVFNQGMSNHSTIIMKKILEIYQGFQGLKTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIEDAPSYPGVDHVGGDMFVSVPKGDAIFMKWICHDWSDAHCLKFLKNCHEALPENGKVILAECLLPEAPDSTLSTQNTVHVDVIMLAHNPGGKERTEKEFEALAKGAGFRGFIKVCCAYNSWIMELLK
What is the function of this protein?
Catalyzes the conversion of caffeic acid to ferulic acid and of 5-hydroxyferulic acid to sinapic acid.  The resulting products may subsequently be converted to the corresponding alcohols that are incorporated into lignins.
What are the official names of this protein?
Caffeic acid 3-O-methyltransferase, CAOMT, COMT, S-adenosysl-L-methionine:caffeic acid 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: GLPG_SALCH
Sequence: MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRVELARFIENPGDPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMIACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVVSALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT
What is the function of this protein?
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
What are the official names of this protein?
Rhomboid protease GlpG, Intramembrane serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S54 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TIG_STRP7
Sequence: MSVSFENKETNRGVLTFTISQDQIKPELDRVFKSVKKSLNVPGFRKGHLPRPIFDKKFGEESLYQDVMNALLPNAYEAAVKEAGLEVVAQPKIDVTSMEKGQDWVITAEVVTKPEVKLGDYKNLEVSVDVEKEVTDADVEERIERERNNLAELVIKEAAAENGDTVVIDFVGSIDGVEFDGGKGENFSLGLGSGQFIPGFEDQLVGHSAGETVDVIVTFPEDYQAEDLAGKEAKFVTTIHEVKAKEVPALDDELAKDIDEEVETLADLKEKYRKELATAKEEAYKDAVEGAAIDTAVENAEIVELPEEMIHEEVHRSVNEFLGNLQRQGINPDMYFQITGTTQEDLHNQYQAEAESRTKTNLVIEAVAKAEGFDASEEEIQKEVEQLAADYNMEVAQVQNLLSADMLKHDITIKKAVELITSTATVK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: SKT_HUMAN
Sequence: MEENESQKCEPCLPYSADRRQMQEQGKGNLHVTSPEDAECRRTKERLSNGNSRGSVSKSSRNIPRRHTLGGPRSSKEILGMQTSEMDRKREAFLEHLKQKYPHHASAIMGHQERLRDQTRSPKLSHSPQPPSLGDPVEHLSETSADSLEAMSEGDAPTPFSRGSRTRASLPVVRSTNQTKERSLGVLYLQYGDETKQLRMPNEITSADTIRALFVSAFPQQLTMKMLESPSVAIYIKDESRNVYYELNDVRNIQDRSLLKVYNKDPAHAFNHTPKTMNGDMRMQRELVYARGDGPGAPRPGSTAHPPHAIPNSPPSTPVPHSMPPSPSRIPYGGTRSMVVPGNATIPRDRISSLPVSRPISPSPSAILERRDVKPDEDMSGKNIAMYRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHIIAYHRTAIRSASAYCNPSMQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVSDLRMIDMHAHYNAHGPPHTMQPDRASPSRQAFKKEPGTLVYIEKPRSAAGLSSLVDLGPPLMEKQVFAYSTATIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSYSKDASSEKMMKTTANRNHTDSAGTPHVSGGKMLSALESTVPPSQPPPVGTSAIHMSLLEMRRSVAELRLQLQQMRQLQLQNQELLRAMMKKAELEISGKVMETMKRLEDPVQRQRVLVEQERQKYLHEEEKIVKKLCELEDFVEDLKKDSTAASRLVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAILRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDAAQAAQYMAMEKATAAEVLKSQEEAAHTSGQPFHSTGAPGDAKSEVVPLSGMMVRHAQSSPVVIQPSQHSVALLNPAQNLPHVASSPAVPQEATSTLQMSQAPQSPQIPMNGSAMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLDHYNGKEFEKLLEEAQANIMKSIPNLEMPPATGPLPRGDAPVDKVELSEDSPNSEQDLEKLGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRKENITAKASSEDAGPSPQTRATKYPAEEPASAWTPSPPPVTTSSSKDEEEEEEEGDKIMAELQAFQKCSFMDVNSNSHAEPSRADSHVKDTRSGATVPPKEKKNLEFFHEDVRKSDVEYENGPQMEFQKVTTGAVRPSDPPKWERGMENSISDASRTSEYKTEIIMKENSISNMSLLRDSRNYSQETVPKASFGFSGISPLEDEINKGSKISGLQYSIPDTENQTLNYGKTKEMEKQNTDKCHVSSHTRLTESSVHDFKTEDQEVITTDFGQVVLRPKEARHANVNPNEDGESSSSSPTEENAATDNIAFMITETTVQVLSSGEVHDIVSQKGEDIQTVNIDARKEMTPRQEGTDNEDPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMMMEEKIEEEEEEENGDSVVQNNNTSQMSHKKVAPGNLRTGQQVETKSQPHSLATETRNPGGQEMNRTELNKFSHVDSPNSECKGEDATDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEIARSQPEDTPENTVRRQEQPSIESTSPISRTDEIRKNTYRTLDSLEQTIKQLENTISEMSPKALVDTSCSSNRDSVASSSHIAQEASPRPLLVPDEGPTALEPPTSIPSASRKGSSGAPQTSRMPVPMSAKNRPGTLDKPGKQSKLQDPRQYRQANGSAKKSGGDFKPTSPSLPASKIPALSPSSGKSSSLPSSSGDSSNLPNPPATKPSIASNPLSPQTGPPAHSASLIPSVSNGSLKFQSLTHTGKGHHLSFSPQSQNGRAPPPLSFSSSPPSPASSVSLNQGAKGTRTIHTPSLTSYKAQNGSSSKATPSTAKETS
What is the function of this protein?
Required for normal development of intervertebral disks.
What are the official names of this protein?
Sickle tail protein homolog.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FER_HALSA
Sequence: MPTVEYLNYETLDDQGWDMDDDDLFEKAADAGLDGEDYGTMEVAEGEYILEAAEAQGYDWPFSCRAGACANCASIVKEGEIDMDMQQILSDEEVEEKDVRLTCIGSPAADEVKIVYNAKHLDYLQNRVI
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
Protein: QUEA_STRPQ
Sequence: MNTNDFDFELPEELIAQTPLEKRDSSKLLIIDHRQKTMVDSHFDHIIDQLNPGDALVMNNTRVLPARLYGEKPDTHGHVELLLLKNTQGDQWEVLAKPAKRLKVGSQVNFGDGHLKATIIDELEHGGRIVEFSYDGIFLEVLESLGEMPLPPYIHEKLEDAERYQTVYAKENGSAAAPTAGLHFTTDLLKKIEAKGVHLVYLTLHVGLGTFRPVSVDNLDEHDMHSEFYSLSEEAAQTLRDVKQAGGRVVAVGTTSIRTLETIGSKFQGDIQADSGWTNIFIKPGYQFKVVDAFSTNFHLPKSTLVMLVSAFAGRDFVLEAYRHAVDEKYRFFSFGDAMFVN
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_STAES
Sequence: MTNFTHINKQGNAKMVDVSNKEITKRVAEAHSSIIVNEKIYSQITQNTNSKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDISFKWDSNNDDSYRLNITAVVSTTGKTGVEMEALTAASVTALTIYDMTKAIDKGMIIGETYLESKSGGKSGDFHRKN
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: LSPA_NEIMB
Sequence: MSSSVSSKTRYWVLALAAIVLDQWSKWAVLSSFQYRERVNVIPSFFDLTLVYNPGAAFSFLADQGGWQKYFFLVLAVAVSAYLVRAILRDEFATLGKTGAAMIIGGALGNVIDRLIHGHVVDFLLFYWQNWFYPAFNIADSFICVGAVLAVLDNIVHRKTQEEKY
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HCAR2_MOUSE
Sequence: MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
What is the function of this protein?
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase.  This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.  Mediates nicotinic acid-induced apoptosis in mature neutrophils.  Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.
What are the official names of this protein?
Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109, G-protein coupled receptor 109A, G-protein coupled receptor HM74, Niacin receptor 1, Nicotinic acid receptor, Protein PUMA-G.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MEND_ECO27
Sequence: MSVSAFNRRWAAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSKQPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHPTHSISLPRPTQDIPARWLVSTIDHALGTLHAGGVHINCPFAEPLYGEMDDTGISWQQRLGDWWQDDKPWLREAPHRESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPLIGDVLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEPEEYWIVDDIEGRLDPAHHRGRRLIANIADWLELHPAEKRQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRISDYLPEQGQLFVGNSLVVRLIDALSQLPAGYPVYSNRGASGIDGLLSTAAGVQRASGKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNGGQIFSLLPTPKSERERFYLMPQNVHFEHAAAMFELKYHSPQNWQELETTLVDAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: LIPA_COXB2
Sequence: MTTYDPSQKSLGKEKLSRIPVKIEATHTPLRKPDWIRIRLSTDSKVSQLKKLLRENHLVTVCEEASCPNLNECFGHGTATFMIMGDKCTRRCSFCDVGHGRPDPLDPEEPVNLANTVSIMSLRYVVITSVDRDDLRDGGAQHYAQCINAVREKNPGIKVEVLVPDFRGRMEKALDQLAQGLPDVFNHNIETAPRLYKQARPGADYPWSLALLQTFKKRFPGIPTKSGMMLGLGETREEVEMVMRDLRQHEVDRLTLGQYLQPTRYHMPVDRYVTPQEFQELGELAKKLGFSNVASGPLVRSSYHADLQAQGERVS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_VIBVU
Sequence: MKTFVAKPETVKRDWYVVDAEGKTLGRLASEIASRLRGKHKAEYTPHVDTGDYIIVINAEKVTVTGNKAAAKTYYRHTEFPGGIKSITFDKLIVRKPEMVIELAVKGMLPRGPLGRAMYRKLKVYAGAEHNHVAQQPKVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ORM2B_HUMAN
Sequence: METANYTKVTEFVLTGLSQTPEVQLVLFVIFLSFYLFILPGNILIICTISLDPHLTSPMYFLLANLAFLDIWYSSITAPEMLIDFFVERKIISFDECIAQLFFLHFAGASEMFLLTVMAFDLYTAICRPLHYATIMNQRLCCILVALSWRGGFIHSIIQVALIVRLPFCGPNELDSYFCDITQVVRIACANTFPEELVMICSSGLISVVCLIALLMSYAFLLALLKKLSGSGENTNRAVSTCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVFNTLIFPLHNPIIYTLRNKEVKAAMRKLVTKYILCKEK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 4M2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL6_PSELT
Sequence: MSKLGKKPILIPSGVQINIEGDMISVKGPKGTLSQRLSPYIKVAIEENKLWVQQNEESIVRRSQRKMLRTFQGTYWSLIKNMITGVTEGFEKQLEIVGVGYRAQLQGNKVSLQLGYTHPIVLEPPVGVSVEVPAPNVVVVKGIDKQKVGQFAAEVRSWRKVNVYSGKGVKYRNEVVKLKEGKKA
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RSMA_YERE8
Sequence: MNNRVHQGHFARKRFGQNFLNDQFVIDSIVSAIHPVPGEAVVEIGPGLGALTEPVAARMDHMTVIELDRDLADRLASHPQLKDKLTIHQEDAMKINFSELAELAGQPLRVFGNLPYNISTPLMFHLFSYTSAIRDMHFMLQKEVVNRLVAGPNSKAYGRLTVMAQYYCNVIPVLEVPPTAFTPAPKVDSAVVRLIPHVNTPNPVGDVRMLSRITTQAFNQRRKTVRNSLGDLFTPEQLIELGIDPILRAENISVAQYCKLANWLSAQSTPQE
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTR10_YEAST
Sequence: MDNLQVSDIETALQCISSTASQDDKNKALQFLEQFQRSTVAWSICNEILSKEDPTNALLELNIFAAQTLRNKVTYDLSQLENNLPQFKDSLLTLLLSHNQKLIITQLNVALARLAIQFLEWQNPIFEIISLLNSSPSILLNFLRILPEETLDIASTSLTEVEFNSRIHELIDPIAEDVLKFLVSCIDLLQNTDGNSSSSISLEQILRCLNSWSYEFPVEQLLTVQPLINLVFETISNGNESDMEAFDSAIDCLCVILRESRDTTNEQLISALFHQLMLLQEKLLPTLFTDHPLNDEYDDDLLEGMTRLFVEAGEAWSVVISKNPDFFKPMVLVLLMLTCKNEDLDVVSYTFPFWFNFKQSLVLPRYQESRKAYSDIFVKLINGIITHLQYPSGQFSSKEEEDKFKDFRYHMGDVLKDCTAVVGTSEALSQPLIRIKSAIENNNSWQIMEAPLFSLRTMAKEISLTENTILPEIIKIICNLPEQAKIRYASTLVLGRYTEWTAKHPELLEVQLQYIFNGFQLHEGSSDMQSIITASSHALMFFCSDCSKLLVGYIDQLINFFLNVQSSIDIESQFELCQGLSAVINNQPEAKVSVIFQKLVDDNLRQIEALIPQWKANPTLLAPQIADKIDLLYALFEELKPRYNYPQQGSEPLLPRIEFIWKALRTLLVDAGAMTDSIIVERVAKLLRRIFERFHVFCEPILPSVAEFLIQGYLTTGFGSYLWCSGSLIVIFGDDESFPISPSLKDAVWKFALSQCETFILNFNKFDKLQLNDYHEAIIDFFSLISDLIMFYPGAFLNSTELLGPVLNVALECVNKLDNYDAYICILRCLDDIISWGFKTPPISTVSIEIVPDEWRKQVINEVVIAHGNQLILVLFIGLVTTFENTAHSDAISCIVKCLRILTEANNNDATICIDWIYKVVEQLGQVTLNERDNLAKAVVEGLNSKDYRKVREGIRAFVGWYSRKNINSRFE
What is the function of this protein?
Involved in mRNA transport from nucleus to cytoplasm.
What are the official names of this protein?
mRNA transport regulator MTR10.
What are the subcellular locations of this protein?
Nucleus.
Protein: HMUDK_BPS10
Sequence: MKTKEEFHRIEISKFTEDLREAFGYKIQYRQDLVLVNIRGCNGAGKSTVPMQMLQTDPGAFMLTLDGKDKATVFPSYGFVAMGRYFSKTGGLDGFKNNEETLKVLKLLWELPFSIIMEGVISSTIFSTYCDLFKELEQRNNPKRAVGVLNLLPPFEVCLERIKKRTPEKFDSIKKDQIEGKWRTVNRNAQKFRDAGVTSWDEDNSVIDINDTVSWFFSSIKNNLQPEFTGLRLGVRFPTEEPVKALKKAEKGVKRGKKGRKTSPVAKTLDDNGDGAFLRSLKREIRPHWDPKYLNTPDDNVRLRRDPETGQTLWDMYFINLVERQNIWYRRVIQGKSKPWTDDPVMSTYHFTNVDRRLDRVTLHYIDKVLCNLEDSYESKKFLLLNTFIYRLFVRPETTDAMGYIFPETFEEDWERAKAALRARRESGEPVFTDAYFVNDLKSANPDRANSSNKTENAIHLIQFIIDHLDELAEFTFNPKNSMEEVIEKFTMIPAVGNFNAYEVALDLGIVKEMTGIDFVDWTPDHYANVGPGCKKGIEYVFEDLGNMSHLDIVFFITSVYKGELERLGLEYKYQEGCKELDLRALEGWCCEMSKYFNYYATERGYDWAKGKRPKKKMNLRTDDVSYLNPRISNLVK
What is the function of this protein?
Phosphorylates 5-hydroxymethyluracil (5hmdU) into 5-phosphomethyl-2'-deoxyuridine (5- PmdU) on DNA as a step in the pathway leading to thymidine hypermodifications in the viral genome (PubMed:34522950).  The phosphate is added internally to the DNA polymer (PubMed:34522950).  As a final result of the pathway of hypermodification, alpha-glutamylthymidine (YdTMP) substitutes for about 20% of the thymidines in the viral DNA, the 80% left are dTMP (PubMed:34522950, PubMed:6792371, PubMed:16789224).  These modifications probably prevent degradation of viral genome by the host restriction-modification antiviral defense system (PubMed:34522950, PubMed:21597187).
What are the official names of this protein?
5-hmdU DNA kinase, 5-hydroxymethyluracil DNA kinase, P-loop kinase, gp186.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family. 5-hmdU DNA kinase subfamily.
Protein: RS12_RHIWR
Sequence: MPTINQLIRKGREPQKAKSKVPAMEKNPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNSREVISYIPGEGHNLQEHSVVLIRGGRVRDLPGVRYHVLRGVLDTQGVKDRKQSRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SYA_BORHD
Sequence: MKLDELRKKYIDFFKSKGHCEIAGKSLIPDNDSTVLFNTAGMQPLVPYLLGEMHPSGDMLVDVQKCLRTGDIDEVGDLSHLTFFEMLGNWSLGAYFKELSVKYSFEFLTSPNYLNISKDKLYVSVFEGDESIPRDTETANVWESLGIPKDRIFYLSREHNFWGPVGNTGPCGPDTEIFVDTGKEKCSVRCDITCSCGKYFEIWNNVFMQYKRDENGNYEELKRKCVDTGMGIERTITFLQGKSSVYDTDAFKPIIDKIEKISGKIYGQNLEDDRSIRIIADHIKASCFILADNFAVLPSNIGQGYVLRRIIRRAIRYAKKLGMESYVLADLVDSVEEIYKSFYKELTEKKDFIKAELNVEEEKFFKTLRHGEQEFIKLIQQLSSKSIPGDISFKLYDTYGFPYEITEELATEYGFSIDKAGFEEHFKKHQEVSKKGGDKVFKGGLADCTYETTKLHTATHLLHKALQLVLGEHVRQKGSNITAERLRFDFNHPYKMTDDEIKQVEDMVNLQIKNKLSVKRSVMNLDDALAKGAMALFGEKYEDIVSVYEIDGFSIEVCGGPHVKNTGELGTFKIQKEQASSSGVRRIRAILID
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUMD_SALTI
Sequence: MTKPTKDDELYREMCRVVGKVVLEMRDLGQEPKYIVIAGVLRTALANQRIQRSALEKQAMETVINALARS
What is the function of this protein?
In vitro catalyzes the addition of water to fumarate, forming malate.  Cannot catalyze the reverse reaction.  Cannot use the cis-isomer maleate as substrate.
What are the official names of this protein?
Fumarase D.
What is the protein family that this protein belongs to?
Belongs to the FumD family.
Protein: Y1514_YERPE
Sequence: MRNMMSLCWQYLRAFTIIYLCLWAGKALALLLPIVIPGSIIGMLILFVLLTLQILPSPWVKPSCQLLIRYMALLFVPIGVGVMQYYEQLTKQFGPIVVSCFISTLIVMLVVAYSSHYVHRDRKVISPSTPTEGEK
What are the official names of this protein?
UPF0299 membrane protein YPO1514/y2654/YP_1404.
What is the protein family that this protein belongs to?
Belongs to the UPF0299 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRCA_SHIB3
Sequence: MITGIQITKAANDDLLNSFWLLDSEKGEARCIVAKAGYAEDEVVAVSKLGDIEYREVPVEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.