PharMolix/UniProtQA huggingface dataset:
Protein: TRPD_THIDA
Sequence: MITPQQALTRLVEQREIFHDEMLALMRQIMRGELTPVQIAGVITGLRVKKETVGEIAAAAEVMREFALEVPVQQREHLVDTCGTGGDAAHTFNISTTAAFVAAAAGARVAKHGGRSVSSTSGSADVLEALGVNLALTPEQVAASIDAIGIGFMFAPNFHGAMRHAAPVRRELGVRTLFNILGPLTNPANAPHQLLGVFHADLVGILVRVLQRLGSSHVMVVHGSDGMDEITLAGDTLIGELKDGEVSEYTINPREFGLQPCGSDALKVWDATQAKDMLLSVLDDLPGPARDIVLFNAGAAIYVADRAATLGEGIELAREAIRSGAARDKLQQLVAYSTQAKQA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: BUD32_DEBHA
Sequence: MTDHIVKKAQECLPNIPLTVISQGAEALVFYTDVHPYANEPYLQNRGKYVIKYRPSKPYRHPKVDSSITKSRTVGEVKFMYKLNKLNINSPRIISADYNNGIIWMEYIGYSLPNGDVSSFKNWLWYLERNNQDCTSESVEKMCFKVGQLIGKLHLHEMIHGDLTSSNILLNDDEPVLIDFGLSSYSGLAEDRAVDLYVLERAITSTHSVYAKEYNQWLLQGYEDVHKHKEFGKQGQKKLVEVLKKLDDVRLRGRKRSMLG
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.
What are the official names of this protein?
EKC/KEOPS complex subunit BUD32, Atypical serine/threonine protein kinase BUD32.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. BUD32 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, telomere.
Protein: COAX_CERS4
Sequence: MLLAIDCGNTNTVFSIWDGTQFLATWRIATDHKRTADEYHVWLSTLLSLTKIEARISEAVISSTVPRVVFNLRVLCNRYYDCRPLVVGKPECRLPVAPRVDQGTTVGPDRLVNTVAGFHLHGGNLIVVDFGTATTFDVVDADGAYIGGVIAPGVNLSLEALHMAAAALPHVDVTKPQQAIGTNTVACIQSGVYWGYIGLVEGIVRQIRLERDSPMKVIATGGLAPLFDQGFNLFDRVEDDLTMQGLVLIHQYNKDLE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HST4_SCHPO
Sequence: MKVEEHVPLIQESRKRKCQSSENASKRQQLLSKLPLRLHTGNENVDLSPLVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFSSLRAEYKLNCSGKELFDGSVYRDLKSVNIFHAMIRKLHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLETRLEGLQTCIPLPQSAPWPTTIPLHGTLEVVSCTRCSFLKKFNPDIFDRNGVTVCPDCKTENEVRRIAGKRSVIEGCLRPRIVLYNEIHPDSESIGSVCSQDLKSRPDCLIVAGTSCKIPGVKRIIKEMSNCVHKQKGNVIWLNYDEPTKDFLNLCDLVVQGDLQIAIRRLKPLLDAPSWKLKSHSAKRTSKQKSSEQTKITSSTKITKAIGLNTKSNDSSKKDNTSFQLHQVLNSIEIPKVEIKQEVEYATPSPL
What is the function of this protein?
NAD-dependent histone deacetylase, which contributes to both telomeric and centromeric silencing, proper cell cycle progression, DNA damage control, recombination, and genomic maintenance.
What are the official names of this protein?
NAD-dependent protein deacetylase hst4, Homologous to SIR2 protein 4, Regulatory protein SIR2 homolog 4.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SPE8_CAEEL
Sequence: MRSKSSEGDLQPEDTQSREDKETTATYSEDTKPETQKERNAALDNLAKTPIQLVVQPTPLTPAITPCEAPPPPPPPKPSSDNNNSKRLKVKDQLIEVPSDEVGRVENNIDNFPFYHGFMGRNECEAMLSNHGDFLIRMTEIGKRVAYVISIKWKYQNIHVLVKRTKTKKLYWTKKYAFKSICELIAYHKRNHKPIYEGMTLICGLARHGWQLNNEQVTLNKKLGEGQFGEVHKGSLKTSVFAAPVTVAVKTLHQNHLSANEKILFLREANVMLTLSHPNVIKFYGVCTMKEPIMIVMEFCDGKSLEDALLSKEEKVSAEDKILYLFHAACGIDYLHGKQVIHRDIAARNCLLNSKKILKISDFGLSVKGVAIKERKGGCLPVKYMAPETLKKGLYSTASDIYSYGALMYEVYTDGKTPFETCGLRGNELRKAIIGKRISLAVEVELPVFIANIFEQSRQYETEDRISSKQIIQIFKEEVGFHEIETSGILHKLVNSLPRIHNKERKPAAVAV
What is the function of this protein?
Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.
What are the official names of this protein?
Spermatocyte protein spe-8, Defective spermatogenesis protein spe-8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Localizes mainly in the cytoplasm of stage I spermatocytes and at the cell membrane of stage II spermatocytes and spermatids.
Protein: IMDH_NITMS
Sequence: MEFKEGLTFDDVLLVPKYSDITSRSQTDLTTKLSRNITINIPFVSANMDTVTESSMAVAMARAGGIGIIHRFLTIQEQANEVLKVKRSGSVMIENPYSISSDKSIQDALDYAEDKEISGLLVVDSNSKLVGIVTERDLLFAGSNGTIADVMTKDVVTAKPGVSLDEAKDILHKHRIEKLPIVDDSGIIQGLITSKDITNNTDYPNASKDKKGRPLVGAAVGVKGDFLERSESLLNAGADVLVVDIAHGHSENAISTVRNIKKAFPDCELIAGNIATAQGAEDLIKAGVDAVKVGVGSGSICITRVITGSGVPQLTAVMDCAKIGNDHGIPIISDGGTRTSGDATKALAAGASSVMVGSMLGGTDESPGTVLTKNGKRFKVYRGMASLAASIGRKSKETGSISLEDDLNDYVAEGVEAMVPYKGTVTDILKQLAGGVRSGLSYCGAHTIPQMQQNAEFIKMSRAGFAESQPHDVLLM
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: ARGB_MANSM
Sequence: MKPLVIKLGGVLLDTPAAMENLFTALADYQQNFARPLLIVHGGGCLVDDLMKRLNLPVQKKNGLRVTPADQIDIIVGALAGIANKTLVAQAAKFKLNPVGLCLADGNLTQATQFDPELGHVAMVVAKNPALLNNLLGDAFLPIISSIAVDDNGLLMNVNADQAATAIAALINADLVMLSDVDGVLDANKQRLTELNSAQIEQLIEDKVITDGMIVKVNAALDAAKILNCGVDIANWKYPEKLTALFAGEIIGTRINP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGI2_CANGA
Sequence: MAKKEKKAKVATITTKSGESLKVFEELNDFETFLRGEVEDNEFDHVHCKAKYYPPFVLHESHDDPEKIKDTNNSHNKKFVRHLHQHVEKHLLKDIREMFQNPDLKFKNKSKEETFEKITWHYADESELNAKKFRIQLDVTCTHDGAMVDVDYRTEPIAAQEPVI
What is the function of this protein?
Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
What are the official names of this protein?
Respiratory growth induced protein 2.
What is the protein family that this protein belongs to?
Belongs to the RGI1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTC5_ARTOC
Sequence: MGAGQSTDSKALGTSPEEMSHILARRFASKCFTPLELAHLKDNFNSLALKQGDIRYWNEEVLSRFLGIPDGNGKFGDGDLDAGPVIFRMVSYLGAFPFQNTLAPSVLTFDALVKVIVLLTDRYGKVLRRGKKDRIKLLFGSLADVGRKEELPVPDNESKDKPDNTPNKSGTQSQTAGFSIDKPSNDNDDEEDNDDDDLALAALESLDAIEVFKHDQRIDRTVYEAHVSFDTFQRLLMLLVVLAPLRTNEETSQYFSQLNEDSMEAARRCVENILTSFDIGDRKSGIGYETFSWVISSSLPYIFDPLTPLFEHLLFSKNLDLSRRRDSGTSSPSEEKNAAPLSSLTPSKPSITLSGSFESCILDSAIISHLSFFLPTSSPIPNLLQNGTRLHGVFSSDTHGESLTSFSHNVLTWDAPSIMLVTGAKKDPSGDETESITIGAYIPRAWKSSTSASASHHDLSNQFQLPYLFQLSPNHVVMQGSPSINSLKANRPMVSFSTKSGIAIGCKIPPPTRTSLSSDSSRPTPAGGGSLLIDPALENAEFFMSNGLSHEEGVFLPAGAATWSPSHSSSTAASETIHISIYNIEVWGIVHTVTISKHSSSKHSRSSTANGAIPDAIMRQQAHWNFEAREAERRREIHLNVGGGDSEEQTGRALLEMAGIIGSSSRYR
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 5.
What is the protein family that this protein belongs to?
Belongs to the RTC5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPAT_RIPO1
Sequence: MATINDNYLKLKAGYLFPEIARRVKTFAEANPDAKIIKLGIGDVTEPLPEACRTAMIKAIEDMGDRGTFKGYGPEQGYEWLREKIATHDFQARNCDVDASEIFVSDGAKCDTGNILDIFGKNNKIAVTDPVYPVYVDTNVMAGHTGEVNDKGEYEGLVYLPINAENNFIAEIPSQKVDIIYLCFPNNPTGATATKDYLKNWVDYAKANGSIIFFDAAYEAFITDSSLPHSIYEIEGARDCAIEFRSFSKNAGFTGTRCALTVVPKTLTAKASDGSDVELWKLWNRRQSTKFNGVSYIVQRGAEAVYSEAGKAQVQALISFYLENAQIICDKLKGAGFEVYGGVNAPYIWLKTPHNLSSWDFFDKLLQTANVVGTPGSGFGAAGEGYFRISAFNSRENVLEAMKRITSQFHL
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: PUR5_RHILO
Sequence: MSKRDTSQPKTGQPKTSKRRNGLTYAEAGVDIDAGNLMVEKIKPLVRATRRPGADGEIGGFGGLFDLKAAGFTDPVLVAANDGVGTKLKIAIDAGKHDTIGIDLVAMCVNDIVVQGAEPLFFLDYFATGKLDPDQGAAIVGGIAEGCRQAGCALIGGETAEMPGMYHGNDYDLAGFAVGAAERGQLLPTDDIVEGDVLLGLASSGLHSNGFSLVRRIVAASGLAWSDPAPFNDEATLAEALLEPTRIYVKSILKAIRNTHGIKALAHITGGGFPENIPRVLPKDFSAELDLEAIDVPPVFSWLAKTGGVAPEEMMRTFNCGVGMILAVASGQAAQVAAVLQEAGETVTPIGRIVPRRDAGVIYRGSIGL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_NEIG2
Sequence: MTDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGASTLQLAKFYAQSIIESGIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDRGEGGVLVGAPLKGRVLIIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTGELSAVQEVEKQYGLPVAPIASLNDLFILLQNNPEFGQFLEPVRTYRRQYGVE
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ATPL_SODGM
Sequence: MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFIVMGLVDAIPMIAVGLGLYVMFAVA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLPP2_TREPA
Sequence: MRCDATQEKRAHSESGESVFFQKFLETRQILLSGEISKDLAEGIVRQLFVLESLSVSKPIYMYVDSPGGDVDAGYAIFDVIRFVKTPVYTIGMGLVASAGVLVLLAAKKDCRFGLRNSRYLIHQPLSGMRGVATDIEIHARELEKTRSKLNALIASETGVSLDKVAQDTNRDYWLDASQALEYGLISNLIEKRADLPKK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSB_HAEIN
Sequence: MKMHQLRYIVEIVNQNLNVTEAANALYTSQPGISKQVRLLEDELGLEIFERHGKHIKSITPAGKKIISIARELLVKAQGIRAVADEYTRPNHGVLRIATTNTQARYMLPSVIERFSKKYPDVSLHIHQGSPTQIHDALMSGEVDLAITTEAPYLFDDLVQIPCYWWNRAVIVSPEHPLAKVKELTIEELGKYPLVTYTFGFTGVSDLDYAFNSAGILPNIVFTATDADVIKTYVRLGLGVGIMASMAHTALDTDLVLIDASHLFRPSMTNIAFKHSTFLRNYMYDFMEYFSPHLTRSVVEKAERLRDNNSVKKLFEGIELETK
What is the function of this protein?
This protein is a positive regulator of gene expression for the cysteine regulon.  The inducer for CysB is N-acetylserine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator CysB, Cys regulon transcriptional activator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_METS4
Sequence: MTDAPDHHATEKRLITETGVAARVAQIVEPSLEGLGFRLVRVRVTGQNGCTVQIMAERPDGTMTVEDCEAVSRTISPLLDVDDPIGRAYHLEISSPGIDRPLVRAGDFARWAGHEAKVELAVPLEGRKRFRGLIRAPEGATVRIDLPDAKEGTPASYELRLADIGEAHLVLTDDLIRESLRRGSAPAQDEEGEDEAPGAPL
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP1L3_ORYSJ
Sequence: MGRGVSSGGGQSSLGYLFGGGEAPKSAEKPAPVQKPAPSSSAEKLKEIPAGIQSSKANNYMRAEGQNCGNFLTDRPSTKVQAAPGGGSSLDYLFSGNKDGK
What is the function of this protein?
Acts in maintaining the cortical microtubules organization essential for anisotropic cell growth.
What are the official names of this protein?
Protein SPIRAL1-like 3.
What is the protein family that this protein belongs to?
Belongs to the SPIRAL1 family.
Protein: PTH_ACICJ
Sequence: MKLWVGLGNPEPGMARNRHNIGFMAIDVIADRHGFAPWRKRFSGLVSEGSVGGEKIVALKPLTYMNESGRAVQPASAFFKLPPDAVTVFHDELDLIPGKVRVKRGGGAAGHNGLRSIDRTLGTQDYWRVRLGIGHPGDKARVHGHVLGNFAKTDEDWLVDTLEAVSDAAPLLAAGKPEDFMTKVALLTKDTA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP2U1_BOVIN
Sequence: MASPGLPQPPTEDAAWPLRLLHAPPGLLRLDPTGGALLLLVLAALLGWSWLWRLPERGIPPGPAPWPVVGNFGFVLLPRFLRRKSWPYRRARNGGMNASGQGVQLLLADLGRVYGNIFSFLIGHYLVVVLNDFHSVREALVQQAEVFSDRPRVPLTSIMTKGKGIVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFRYVKEEMQKHGDAPFNPFPIVNNAVSNIICSLCFGRRFDYTNSEFKQMLNFMSRALEVCLNTQLLLVNICSWLYYLPFGPFKELRQIEKDLTLFLKKIIKDHRESLDVENPQDFIDMYLLHVEEEKKNNSNSGFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLHPNIQEKIHEEIARVIGADRAPSLTDKAQMPYTEATIMEVQRLSTVVPLSIPHMTSEKTVLQGFTIPKGTIILPNLWSVHRDPAIWEKPNDFYPDRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFVLPKDSKPILTGKYGLTLAPHPFNIIISKR
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).  Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids.  May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes.  May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels.  Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.
What are the official names of this protein?
Cytochrome P450 2U1, Long-chain fatty acid omega-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HMDH_BLAGE
Sequence: MVGRLFRAHGQFCASHPWEVIVATLTLTVCMLTVDQRPLGLPPGWGHNCITLEEYNAADMIVMTLIRCVAVLYSYYQFCHLQKLGSKYILGIAGLFTVFSSFVFSSSVINFLGSDVSDLKDALFFFLLLIDLSKATVLAQFALSSRSQDEVKHNIARGIAMLGPTITLDTVVETLVIGVGMLSGVRRLEVLCCFACMSVIVNYVVFMTFYPACLSLILELSRSGESGRPAWHDKSLIIKALHEEDQKPNPVVQRVKVIMSAGLMLVHAHRWVRCLSIALWPDLTSLRYFCTHCDTGVSYSRWSFASEGEELPTVKLVTGDSVVNSNSTDDAQLHYYIMRWLTVSADHIVILILLLALAVKFVFFETRDELTTTRGMDGWVEVSSPVEHKYVQTEQPSCSAPEQPLEEPPASNRSIDECLSVCKSDVGAQALSDCEVMALVTSGHIAGYQLEKVVRNPERGVGIRRQILTKTADLKDALDNLPYKNYDYLKVMGACCENVIGYMPVPVGVAGPLNLDGRLVHVPLATTEGCLVASTNRGMRALMRCGVTSRIVADGMTRGPVVRFPNIDRASEAMLWMQVPYNFEQIKKNFDSTSRFARLSKIHIRVAGRHLFIRFIATTGDAMGMNMLSKGTEVALAYVQQVYPDMEILSLSGNFCTDKKPAAVNWIEGRGKSVVCEAIVPADIIKSVLKTSVQALMDVNITKNLIGSAVAGSIGGFNAHAANIVTAIFIATGQDPAQNVGSSNCMTLMEPWGEDGKDLYVSCTMPSIEIGTIGGGTVLPPQAACLDMLGVRGANEMCPGENANTLARIVCGTVLAGELSLMSALAAGHLVKSHMRHNRSSVSTSGSEPSTPACKS
What is the function of this protein?
Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CLPS_NITEC
Sequence: MAANNRNPESVIEKGKTRLTPPPLYKVILINDDFTPMDFVVKVLRHFFFMDEEMATRIMLKIHTEGAGICGTYPGDIAATKVQQVNEFSKQNQHPLMCVMEKE
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: GRIK5_RAT
Sequence: MPAELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGTPAEATSPPRPRPGPTGPRELTEHE
What is the function of this protein?
Receptor for glutamate.  L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.  The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.  This receptor binds kainate > quisqualate > glutamate >> AMPA.
What are the official names of this protein?
Glutamate receptor ionotropic, kainate 5, GluK5, Glutamate receptor KA-2, KA2.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: RL16_PEDPA
Sequence: MLVPKRVKHRREHRGRMRGAAKGGKTVAFGEYGLQALTSSWITNRQIEAARVAMTRYMKRGGKVWIKIFPHKSYTSKGVGVRMGNGKGTPEGWVAPVKREKVMFEVAGVPEEVAREALRLAAMKLPVKTKIIEREEVGGESDEG
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: LON_SALAI
Sequence: MATLPVLPLTDAVLLPGMAIPVTLDPTTQAAVDAARATGDQRLLAVPRLDGEYGPVGVVATIEKVGRLPSGEPAAVVRGLARARIGSGVPGPGAALWVEAAELAEPAPAGRARELAREYRALMTSVLQQRGAWQVIDAIERMTDLSELADSAGYVSWLSLAQKTELLAAPDVTTRLELLVGWVRAHLAEQEVAEQINTDVREGLEKSQREFLLRQQLATIRKELGEDEPEGSADYRARVEAADLPAPVRDAALREVGKLERASDASPEAGWIRTWLDTVLEMPWNTRTEDNTDLVAARAVLDADHAGLTDVKDRILEYLAVRNRRVERNLGVVGGRGSGAVLALAGPPGVGKTSLGESVARALGRRFVRVSLGGVRDEAEIRGHRRTYVGALPGRIVRALREAGSMNPVVLLDEVDKLAVGYSGDPAAALLEVLDPAQNHTFRDHYLEVDLDLSDVLFLATANVVEAIPSPLLDRMELVTLDGYTEDEKVAIARDHLLPRQRERAGLTADEVTISDGVLARIAGEYTREAGVRQLERSLAKIFRKVAVTATTDPAPVHVDTGNLHRYLGRPKFSPESAERTAVPGVATGLAVTGAGGDVLFVEATSMAGEPGLTLTGQLGDVMKESAQIALSYLRSNGRRLGLDPNALAGRRIHLHVPAGAVPKDGPSAGITMVTALASLVSGRPVRPEFGMTGEVTLSGRALPIGGVKQKLLAAHRAGLTEVIIPQRNEPDLDDLPAEVREALTVHTLADVADVLALALRPADLDADSLDGEALATA
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTM1_BOVIN
Sequence: MASAPTSKYNSHSLENESIKRTSRDGVNRDVGETLPRLPGEIRITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSALILDVPLGVISRIEKMGGATSRGENSYGLDITCKDLRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPIFAFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYKLCDTYPALLVVPYRASDEDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKEDERYLDVIRETNRQVNKLTIYDARPNVNAVANKATGGGYESDDVYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADRVSSGKSSVVVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNERFLITILDHLYSCRFGTFLYNCESAREKQKVTERTVSLWSLINSNKDKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLDELQLANSAKLSDPSASPSSPSQMMPHVQTHF
What is the function of this protein?
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2).  Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides.  Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome.  Plays a role in vacuolar formation and morphology.  Regulates desmin intermediate filament assembly and architecture.  Plays a role in mitochondrial morphology and positioning.  Required for skeletal muscle maintenance but not for myogenesis.  In skeletal muscles, stabilizes MTMR12 protein levels.
What are the official names of this protein?
Myotubularin, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Late endosome. Cytoplasm, myofibril, sarcomere. Note=Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation (By similarity). In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity).