PharMolix/UniProtQA huggingface dataset:
Protein: KCTD1_BOVIN
Sequence: MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRESGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFPLNGYCHLNSVQVLERLQQRGFEVVGSCGGGVDSSQFSEYVLRRELRRTPRGPSVIRIKQEPLD
What is the function of this protein?
May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD1.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYSI2_PECCP
Sequence: MSEKYVFSEKHPGPLVVEGKLTDAERMKTESNFLRGTIAEDLNDGLTGGFKGDNFLLIRFHGMYQQDDRDIRAERAEQKLEPRHAMLLRCRLPGGVMTPEQWLRIDKFAGESTIYGSIRITNRQTFQYHGILKSNVKPVHQMLNSIGLDALATANDMNRNVLCTSNPIESELHQQAYEWAKKISEHLLPRTRAYAEIWMDQEKVATTDEEPILGSTYLPRKFKTTVVVPPQNDVDLHANDLNFIAIADNGRLVGFNVLVGGGLSIAHGDKATYPRTASELGYISIEHTLAIAEAVVTTQRDWGNRTNRKNAKTKYTLERVGVDNFKQEVEARAGVKFEAVRPYEFTGRGDRIGWVKGIDNKWHLTLFIENGRILDYPGRPLKTGLAEIAKIHKGDFRLTANQNLIIAGVPARSKAKIDALAREHGLIDDSVSEQRKNSMACVSFPTCPLAMAEAERFLPEFVTKVEDIMQQHGVGDEHIVLRVTGCPNGCGRAMLAEIGLVGKAVGRYNLHLGGNREGTRIPRMYRENINETEILAEIDRLIGLWAQDRQPNEGFGDFTIRTNIIRPVLDPARDFYD
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component 2, SiR-HP 2, SiRHP 2.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: ENV1_MOUSE
Sequence: MEGPAFSKPLKDKINPWGPLIVLGILIRAGVSVQHDSPHQVFNVTWRVTNLMTGQTANATSLLGTMTDAFPKLYFDLCDLIGDDWDETGLGCRTPGGRKRARTFDFYVCPGHTVPTGCGGPREGYCGKWGCETTGQAYWKPSSSWDLISLKRRNTPQNQGPCYDSSAVSSDIKGATPGGRCNPLVLEFTDAGKKASWDGPKVWGLRLYRSTGTDPVTRFSLTRQVLNIGPRVPIGPNPVITDQLPPSRPVQIMLPRPPQPPPPGAASIVPETAPPSQQPGTGDRLLNLVDGAYQALNLTSPDKTQECWLCLVAGPPYYEGVAVLGTYSNHTSAPANCSVASQHKLTLSEVTGQGLCVGAVPKTHQALCNTTQKTSDGSYYLAAPAGTIWACNTGLTPCLSTTVLDLTTDYCVLVELWPKVTYHSPGYVYGQFERKTKYKREPVSLTLALLLGGLTMGGIAAGVGTGTTALVATKQFEQLQAAIHTDLGALEKSVSALEKSLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYADHTGVVRDSMAKLRERLNQRQKLFESGQGWFEGLFNRSPWFTTLISTIMGPLIILLLILLFGPCILNRLVQFVKDRISVVQALVLTQQYHQLKSIDPEEVESRE
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
MLV-related proviral Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single- pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. R- peptide: Cell membrane; peripheral membrane protein. The R-peptide is membrane-associated through its palmitate (By similarity). SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. R-peptide: Cell membrane; peripheral membrane protein. The R-peptide is membrane-associated through its palmitate (By similarity).
Protein: CITC_KLEPN
Sequence: MTLILKRVQLLKDKPRREAIDRFLRQHQLSLEADCEMAIIAEYQQRLVGCGAIAGNVLKCIAIDPSLQGEGLSLKLLTELLTLAYELGRSELFLFTKPCNAALFSGAGFWPIAQAGDRAVLMENSRERLTRYCRQLAMYRQPGRKIGAIVMNANPFTLGHRWLVEQAASQCDWLHLFVVKEDASCFSYHDRFKLIEQGITGIDKVTLHPGSAYLISRATFPGYFLKEQGVVDDCHSQIDLQLFRERLAPALQITHRFVGTEPLCPLTRNYNQRMKSLLEAPGDAPPIEVVELARIEKNGGPVSASRVRELYRQRNWQAVAALVPPGTLSFLMQLAESEHQTA
What is the function of this protein?
Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
What are the official names of this protein?
[Citrate [pro-3S]-lyase] ligase, Acetate:SH-citrate lyase ligase, Citrate lyase synthetase.
Protein: AMY_BUTFI
Sequence: MKRGKLWGRLVSAAGLSLSIFLSSIGNVSTAYAMESNDALVLDETKENTESATDASSNEASDAEADNDTDEAITDASSKELSAENDGASESDSSFDEYDHTALPETDEITVTAAGELSTAKAELYTLAPREAREADNSLVTRDSIHDGAILHAFCWSFNTIADNMADIADAGYTAVQTSPINECLSTNPGMNLHGPDGMWYYHYQPTDWVIGNYQLGSRDEFKHMCDVADEYGVAVIVDILPNHTTPSTGSIAKALMEAAGGSDALYHATGKIGGGYTDRLELTYYSMGGLPDVDTENTGFQQYFYEFLKDCVYLGADGFRIDTAKHISLPDDPVPSDYSDAGRNTFYPNMREALNEYSEEVGTKSYDELFVYGEVLQGTNDRLAAYQQYIGGTTASNYGSSLRSALSSGNLSVNRLLDYQIYDDTAYGSTYTADTEKLVTWVESHDNYMNDSESCWKSIDDDMVIMGWSIIAARDAGTPLFFSRPNNSSAENPYGDNLIGAAGSPIYKAPEVKAVNLFREKMGEADEYLSNPGGNIQTLMIERYNDTVQGAVIVNAAQTRTTISTETHLSDGIYPDQVEGSNSVFLVKDGVLSGSVEGEGVVVLSEKMDGTGKVVSFYNNKNWNGVVARVDNAEETLDTIDENDGWFQVTVLDDEFTIRFESADGKEVSPEFQITAESGTFATPDSSELYYSKAEAEEGLGIHTYPVYFFNTENWGSVYTYGWLDGGAQLFGGWPGTVAVNEGSGWYRADVKTTGEITAFNLIFNNGNGIQTVNVEGITPDSKDIYLAVDAEKSNGQLIVNRYEDKESAEKALGVSGSYTTAYFYNTEGWDKVCAYTWGATALGDWPGKELTQDEDGWYSVVLPAGPSEDLNIIFNNGNNGKQTNDMKISDMKYRFILNNGISYQKYGSKKDAMEAIAGAGDVTYETVYFYNEKADDANWKNVYLYVFGGTDGEYNNLVGTWPGKLMEKEEDSNG
What are the official names of this protein?
Alpha-amylase, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: QUEA_GEOMG
Sequence: MRVDDFDYELPPELIAQEPLDRRDATRLMTVDRLKGEVGEVSFREITRLFRPGDLLVVNDTRVIPARFFGVKESGGRVEVFLERRLAAVGERWQCLLRSSKPSRPGTRIVLAEGVSAEVIGRSDGDTWCVSFTPVTGFDEWLERNGAMPLPPYIRRSAADADRERYQTVFSRQRGAVAAPTAGLHFTPELLDELRERGVEIATLTLHVGLGTFMPIRVERVEEHRMHRERYIIPSATADAVNARKGGKGRVIALGTTTCRTLEHAARDDGRVAAGAGETGIFIYPGYHFKTVDALITNFHLPKSTLLMLVSAFAGKELLFRAYHEAVTRRFRFFSYGDAMFVH
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YACG_VIBPA
Sequence: MSKITIVQCPQCGTDVEWGEQSPHRPFCSKKCQMIDFGEWADEENAIAGAPDMSDSDGWSEDQY
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: 368R_IIV6
Sequence: MSIPNLSSVTQLLSIATGLVSTNNPVVVPVVTQILSVVSQLLSGTPASVVLPILQGLIPLLTNFPLILIQLLSVIAGLQGLPVPSSFSPDYKV
What are the official names of this protein?
Uncharacterized protein 368R.
Protein: LFTR_BORPD
Sequence: MKLPWLSPDTPFPPVEHALSDPAGLLAAGADLSLERLTAAYSNGIFPWYSEGEPILWWSPDPRMVLACADFAPSHSLRKLLRQIAREESALLPRVQVRVDTEFDAVVAQCAAPRDGQAGTWITADMQQAYRAWHAAGVAHSVETWIDGELAGGLYGISLGRMFFGESMFTRVPDASKVALAYLVAFLRRAGVEWIDCQQQTRHLASLGARPVPRARFVEHIRQAIAGPAPAWQSGRLDSQGSLHPAPVSTLLY
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1629_ARCFU
Sequence: MTVDKKELNVAISGIGNFKTYAIVFKPNYLYSTSPSLIYEHSAVLKMQNSAIVVDSDQSTFSSEKISIYLINATFNPFSTTENVNLIFQPISYGGAIKFTGTITFECYNEQTAEWWNETLGDIYGAGNVDRDGTNVTVILNDVELSINYLIATATSSRSVRYDVDLEPKHLKPLLNDSATYQLSAGSVKDFGVLVLDEYLNPIRNKAKLASVSINPDCGSCNKYLNSNGEVWCSFTPFPPRRSCASP
What are the official names of this protein?
Uncharacterized protein AF_1629.
Protein: SDHL_DICDI
Sequence: MGLKTTISPDSSFDKIINTKTSPPLHINSPMLESLALSKLFKEENAKVWMKVDALQPSGSFKIRGVGLLCNQLLKEKKSKNEEAHFICSSGGNAGKSVAYAGRKLNVKTTIVLPNTIPEATIEKIKDEGANVIVHGTIWDEANTFALELAEKEGCTDCYIHPFDHPLLWEGHSTMIDEIYQDVQNGVCEKPDVILFSVGGGGMMIGILQGLDRYGWNDIPIVTVETVGSHSFWKSFQEKQLTKLDVSEVTSVIKTLSTRSVCSEAWEISKRFNIKPILVTDRDAVDACLKFVDDERILVEPSCGATLSVLYSKKLSTLLDINSKNILTIVCGGNGTSILQLNDLLQTLPK
What are the official names of this protein?
L-serine dehydratase, SDH, L-serine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGUL_ORYSJ
Sequence: MASGSEAEKSPEVVLEWPKKDKKRLLHAVYRVGDLDRTIKCYTECFGMKLLRKRDVPEEKYTNAFLGFGPEDTNFALELTYNYGVDKYDIGAGFGHFAIATEDVYKLAEKIKSSCCCKITREPGPVKGGSTVIAFAQDPDGYMFELIQRGPTPEPLCQVMLRVGDLDRSIKFYEKALGMKLLRKKDVPDYKYTIAMLGYADEDKTTVIELTYNYGVTEYTKGNAYAQVAIGTEDVYKSAEAVELVTKELGGKILRQPGPLPGLNTKIASFLDPDGWKVVLVDNADFLKELQ
What is the function of this protein?
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (By similarity).  Involved in the detoxifiation of methylglyoxal.  Can functionally complement growth defect of a yeast mutant lacking GLY I.  Involved in abiotic stress response.  Over-expression of GLYI-11 in tobacco increases tolerance to osmotic, oxidative and salt stresses (PubMed:24661284).
What are the official names of this protein?
Lactoylglutathione lyase, Aldoketomutase, Allergen Glb33, Glyoxalase I, Glx I, Glyoxylase I 11, OsGLYI-11, OsGLYI11, Ketone-aldehyde mutase, Methylglyoxalase, PP33, S-D-lactoylglutathione methylglyoxal lyase.
What is the protein family that this protein belongs to?
Belongs to the glyoxalase I family.
Protein: PSA3_MOUSE
Sequence: MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSANDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).  Binds to the C-terminus of CDKN1A and thereby mediates its degradation.  Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
What are the official names of this protein?
Proteasome subunit alpha type-3, Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8, Proteasome subunit K.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: CYS14_NEUCR
Sequence: MASTSTAGDRIKKFLGIPADERLNDTACYVDGSFVESEPTTQDFLNEIRPTVQGTLNYLRELFPFVNWIFHYNLTWLLGDFIAGVTVGFVVVPQGMAYAKLANLAPEYGLYTSFVGFVLYWAFATSKDITIGAVAVMSTIVGNIIANVQKDHPDFDAGDIARTLAFISGAMLLFLGLIRFGFIVEFIPIVAISAFMTGSAISIAAGQVSTLMGIPNINSREETYKVIINTLKGLPNTHLDAAMGLTALFGLYFIRWFCTQMGKRYPRQQRAWFFVSTLRMVFIIILYILVSWLVNRHVKDPKKAHFKILGHVPSGFQHKGAPRLDNEILSAISGDIPTTILVLLIEHIAISKSFGRVNNYIINPSQELVAIGFTNLLGPFLGGYPATGSFSRTAIKAKAGVRTPLAGIFTAVLVLLALYALTSVFFYIPNSALAAMIIHAVGDLITPPREVYKFWLTSPLEVVIFFAGVFVSIFTSIENGIYVTVAASGAVLLWRIAKSPGKFLGQTEIYTAPRELVRGSKDSGLTQSLLQKSEHHTAFLSLDRDDLSNPELQISTPWPGIFVYRFGEGLNYVNSAKHLDNLTIHVFKHTRRTELNKFEKLGDRPWNDPGPRRGQAFLTDELVSRPTLRAIILDFSAVNCIDVTAAQALQDLRNQFDRYAHPDKVEWHFAGVSNRWTKRALVASGFGVDSLRTAKVQRENHKGGVQEVDQGPLVAIGPSVSASDIEAVPVGTSGSGSTDEKRPEGEGGATNGGMEKGSANGEDISTVPTATSADACALARDAGGKRLVPVFGINRPFFHIDVATALKSAVRNTGVVAAE
What is the function of this protein?
Uptake of sulfate into the cell.
What are the official names of this protein?
Sulfate permease 2, Sulfate permease II.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRUD_PSEA8
Sequence: MSVLGELDLLGPRAHGAACGEAVLKAVAEDFQVDEVLDIPLSGEGEHLWLWVEKRGLNTEEAARRLGRAAGVQQKNVSYAGLKDRQALTRQWFSLHLPGKADPDLGAAEGADLRILRRTRHSRKLQRGAHAANGFTLRLTGLRAERALLDARLERIAADGVPNYFGLQRFGHGGGNLVDARSCAEQDLLPANRNLRSRFLSAGRSYLFNRLLAERVAEGSWNRAAVGDLLAFTDSRSFFLAGEEECRDARLAALDLHPTGPLWGEGDPPSGAGVLERELALAGSEPALCRWLAKAGMAHERRILRLPIQGLAWHYPEPDVLQLEFVLPAGCFATVVVREILDLVPTGQTENPCAY
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: FAR2_AUSGA
Sequence: PDYLQLARA
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-2, FMRFa-2.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PENM_PENRW
Sequence: MKDGEETPSVDGSTSASNREKLGTDLEIGPVDLSDGGKEEKVKDPNLVDWDGPDDPENPLNWTSKRKITATCSIALITFLTPLGSSMFAPGVGQLVKDFNVTSTELSSFVVSVYLLGYCFGPLIIAPLSELYGRQYVYHVCNILYVIWTIACAFAPEIGSLVVFRFFAGLAGSCPLTIGAGSIADMFVQEQRGGAMAAWALGPLIGPVVGPVAGAYLAQAKGWRWSFYVLAMAAGAITISSLFSIRESYAPTLLARKTKKLQKETGNMNLRSALDTGRTPKELFLYSIVRPTKMLFRSPIVFLLSLYVGVIYGYLYLLFTTITSVFQQQYNFSQGAVGLTYLGLGVGSLIGLFLIGATSDRLLNYLAAKNGEKKPEYRLPPMVPGAIFVPISLFMYGWTAYYQTHWIVPIIGTSFLGTGMMITFMCVSTYLVDAFTNYAASVMAANTVFRSLAGALLPLAGPKMYAVLGLGWGNSLLGFIALAFCALPVIFWIYGERIRTSPKFQVTF
What is the function of this protein?
MFS-type transporter involved in penicillin production, most likely through the translocation of isopenicillin N from the cytosol to the peroxisomal lumen across the peroxisomal membrane.
What are the official names of this protein?
MFS-type transporter penM.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein. Note=Probably recruited to the peroxisomal membrane by pex19.
Protein: VTS1_CRYNH
Sequence: MASHTLRPHRSPSPSPEPPVNLANPAKLTRQSLGPPTSGNSKGFGSLGLGPGLASPSSPSQPRHVSSSVAMGMGNRDSLSPRPSGVGSGRAVSATTGPRPSSEFIPTREAKTPEAEQIDQWFKHLANWEATLEEMAAASTDQNFTEELGAIEQWFRVLSEAERTAALYSLLQYSTPVQIRFFISVLHHMSQSDPMSALLSPSLSGSNAFQTQVESKLSNMNLKSPSAGGGAGFAGSSGNGHYLAPDDAAAKAAKARQNRISAPGTLQPHDRWQGQLDQVVERGTSPGLESNMSGRSRSKSPTPEPRPKSTDFSGKPRESLRRESAAFPRSPRVSAGSPGIGLGIGHESPMASPFGNNASWASMVNTPLVQNFNDGKLVAPASVADLSQALNMATLQLNNPGYLPLDDARKYRRPTGGLASGQTSRNVSGQYNDDGEIVNPHTTQPGTPSGLLPNQFGGGRSPLVDQFGLGGLGIGADSTTLANLGLNYNLAGLGGVNPGLNGLTAAQAQAAQMLAMQQQLQNSQYSPFNASAPSLQPGLNPSRRGAGRGQSSHLNQHYNQHQQQHQPGRRSPNPLKSHSPAPGQQTGGGGAGGGAGVAGPEDVDVKVLEDVPNWLRVLRLHKYTPNFEKSNWNDMVLMTDQDLQDNGISAQGARTKFLKVFYNVRTKMDIAHPPGQEEYAPGPKESK
What is the function of this protein?
RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
What are the official names of this protein?
RNA-binding protein VTS1.
What is the protein family that this protein belongs to?
Belongs to the VTS1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, P-body. Note=Localizes to P-bodies at high temperature.
Protein: TOM71_ARATH
Sequence: MESTISLKVNKGKGKGSKGASSSDDKSKFDVVKEWTNWSLKKAKVVTHYGFIPLVIFVGMNSDPKPHLFQLLSPV
What is the function of this protein?
Seems to act as a modulator of the dynamics of the mitochondrial protein transport machinery.  Seems to promote the dissociation of subunits of the outer membrane translocase (By similarity).
What are the official names of this protein?
Mitochondrial import receptor subunit TOM7-1, Translocase of outer membrane 7 kDa subunit 1.
What is the protein family that this protein belongs to?
Belongs to the Tom7 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: SMPX_PONAB
Sequence: MSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPEVEEGVPPTSDEEKKPIPGAKKLPGPAVNLSEIQNIKSELKYVPKAEQ
What is the function of this protein?
Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.
What are the official names of this protein?
Small muscular protein, Stretch-responsive skeletal muscle protein.
What is the protein family that this protein belongs to?
Belongs to the SMPX family.
Protein: PNP_BURL3
Sequence: MSMFNKVVKEFQWGQHKVRLETGEVARQASGAVIVDVEDTVVLATVVGAKSAKPGQDFFPLTVDYLEKTYSAGKIPGGFFRREGRPSEHETLTSRLIDRPLRPLFPEGFYNEVQVVIHVLSVNPEIPADIPALIGASAALAVSGLPFNGPVGAARVAYIDNAYVLNPTRDQIKASSLDLVVAGTERAVLMVESEADQLSEDVMLGAVVFGHEQMQVAIDAIHELVREGGKPEWDWQPAPKNEPLIARVTELAQNDLLAAYQLRDKQARSTKLKEVYAATSAKLEEDASAAGTVAADKATVGNVLFDIEAKIVRSQILNGEPRIDGRDTRTVRPIEIRTGVLPRTHGSALFTRGETQALVVATLGTKGDEQIIDALEGEYRERFMLHYNMPPFATGETGRVGSPKRREIGHGRLAKRALVKCLPSADEFGYSIRVVSEITESNGSSSMASVCGGCLALMDAGVPMKAHVAGIAMGLILEGNKFAVLTDILGDEDHLGDMDFKVAGTEQGVTALQMDIKIQGITKEIMQVALAQAKEGRMHILGKMTSAVSGANTQLSEFAPRMITIKINPEKIRDVIGKGGSVIRALTEETGTTIDISDDGVVTIASTNSDGMAEAKKRIENITAEIEVGQVYEGTVLKLLDFGAIVNLLPGKDGLLHISEIVNERVKDINDYLKEGQQVKVKVIQTDEKGRVRLSAKALLNEAAAASQSDTPPQQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_CARHZ
Sequence: MEHQELNELVKVRLEKLSELRKMGIEPYGGKFERTHTAKEILDNFEQLVDKTVKIAGRIMAKRGHGKASFAHIQDMSGKIQIYARQNELGIDAYKLFEKLDIGDIIGVTGHVFKTQKGEITVWLSSFEILAKSLRPLPEKWHGLTDVELRYRQRYVDLIVNPEVRETFILRSRIVKTIREFLDQKGFLEVETPMMHPIAGGAAARPFITHHNALDMKLYLRIAPELYLKRLLVGGFEKVYEINRNFRNEGISTKHNPEFTMLELYQAYADYHDMMDITEELITHVAEKVLGTLEITYQGTPINLHRPWKRIPMLKAIEEATGVDFAGVKDPVQAYAKAKELGVPVEEGMGWGEIITAVFEEKVEPTLINPTFVIDYPVEVSPLAKRQKENPDLTYRFELFIYGREMANAFSELNDPIDQKERFLKQLEARAKGNEEAHMMDEDYITALEYGMPPAGGLGIGIDRLVMLLTDQASIRDVILFPLMRPRD
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANE_EDWI9
Sequence: MSVFTTLQQHIQRNGALIVSCQPVPGSPMDSPEIVAAMATAAAQAGAAALRIEGVANLQAVRPHVSLPIIGIIKRDLDESPVRITPFLRDIDDLVQAGADIIAFDGTQRPRPERREALLARIQHHGRLAMADCSSLEDGLYCQRLGCDFIGTTLSGYTHGETPCEPDFALVHALSNAGCRVIAEGRYNTPAQAAQALSQGAWAVTVGSAITRIEHICQWYCQALQAEAHHEYAGH
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: CYB_AKOIN
Sequence: MKILRKNHPLLKIINHSFIDLPAPSNISSWWNFGSLLGVCLMIQILTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYLHANGASMFFICLFIHVGRGIYYGSYVLSETWNIGIILFLTTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGNTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAFVLVHLLFLHETGSNNPSGLNSDSDKIPFHPYYTIKDLLGILFLLMALMILALFFPDILGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSIIILAAFPLLNTSKQHGLIFRPVTQTIYWIFIANLLVLTWIGGQPVEYPFTMIGQIASVIYFATIIVLMPVSNTIENNIIKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KNOX8_MAIZE
Sequence: ELKHQLLRKYGGYLGGLRQEFSKRKKKGKLPKEARQKLLHWWELHYKWPYPSETEKMALAETTGLDPKQINNWFINQRKRHWKPA
What is the function of this protein?
Probably binds to the DNA sequence 5'-TGAC-3'.
What are the official names of this protein?
Homeobox protein knotted-1-like 8.
What is the protein family that this protein belongs to?
Belongs to the TALE/KNOX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IL10_SHEEP
Sequence: MPSSSAVLCCLVFLAGVAASRDASTLSDSSCTHFPASLPHMLRDVRAAFGKVKTFFQMKDQLNSMLLTQSLLDDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKRVFNMLQERGVYKAMSEFDIFINYIESYMTTKM
What is the function of this protein?
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.  Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.  Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity).  In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
What are the official names of this protein?
Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF.
What is the protein family that this protein belongs to?
Belongs to the IL-10 family.
What are the subcellular locations of this protein?
Secreted.