PharMolix/UniProtQA huggingface dataset:
Protein: SECA_WIGBR
Sequence: MLIKLFGKIFKNSNDRALKVINLIVKKINSLESTIEKLTDQQLSSKTIEFKNRISDGDNLNNILPEAYAVVREASKRIFNMRHFDVQLMGGIVLNRRCIAEMSTGEGKTLTSVLPAYLHSLLGKGVHIVTVNDYLAKRDANNNKPLFEFLGITVGINLPGLNNIEKRNAYLADITYGTNNEYGFDYLRDNMIFNENEKVQRNLYFALVDEVDSILIDESRTPLIISGPIKSNSDIYYKINKLVPNLIKQEKEDSENFQGNGHFTIDEKSKQINMTERGLILVENLLIKNHLMNKNDSLYSSKNISLMHHFISALRAHKLFFKNVDYIVKNNEIIIVDEHTGRTMHGRRWSDGLHQAIEAKEKVNINNENQTLASITFQNYFRLYEKLSGMTGTAYTEAAEFKAIYKLDTIIIPTNRPVIRNDLPDLIYMTEKEKINAIINDIKNCYSKNIPVLVGTISIEKSENISNILKKLRIKHNVLNAKFHELEAEIISQAGCPKSITIATNMAGRGTDIILGGNWKSEFFNKKNINKKRIKKIKESWVKKNNYVIKLGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYVSMEDNLMRIFASNRIIQTMQKLGMKTGESIEHKWITKAISNAQKKVENRNFDMRKQLLDYDDVANEQRKAIYSQRTEILNSLDIKDIIDNIRKDVLKKIFEKYKTKHSEKINVNLIKIENLIKKYFCIEISILSLYKENKCNLEKLYKNILIIILKKYNEKENKIGSTNLRIFEKNIMIKTLDSFWREHLSSIDYLRQGIHLRGYAQKDPKQEYKRESFIMFENMLYELKIEVITIISNVKIKS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: ISCS_NEIG1
Sequence: MTVKTPVYLDYAATTPVDKRVAEKMIPYLTETFGNPASNSHAFGWTAEEAVEKARADIAALINADPKEIVFTSGATESDNLAIKGAANFYKTKGKHLITVKTEHKAVLDTMRELERQGFEVTYLGVQENGLIDLEELKAAIRDDTILISIMWVNNEIGVVQNIPAIGEICRERKIAFHVDAAQACGKVPVDVEAAKIDLLSMSAHKVYGPKGIGALYVRRKPRVRLEAQMHGGGHERGFRSGTLPTHQIVGMGEAFRIAKEELAQDTAHYLKLRDIFLKGIEGIEEVYINGDLEHRAPNNLNVSFNFVEGESLIMAVKELAVSSGSACTSASLEPSYVLRALGRNDELAHSSLRITFGRMTTEEEVQFAAELIKSKIGKLRELSPLWEMFKDGIDLNSIEWAAH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPR3_ARATH
Sequence: MSSLSRELVFLILQFLEEEKFKESVHRLEKESGFFFNTKYFDEKVLAGEWDDVETYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDRQEKAKAVEILVQDLRVFSTFNEELYKEITQLLTLQNFRENEQLSKYGDTKTARGIMLGELKKLIEANPLFRDKLMFPTLRSSRLRTLINQSLNWQHQLCKNPRPNPDIKTLFTDHTCTLPNGPLAPSAVNQPVTTLTKPAAYPSLGPHVPFPPGPAAANAGALASWMAAASGASAVQAAVVTPALMPQPQNQMSILKRPRTPPATPGIVDYQNPDHELMKRLRPAPSVEEVTYPAPRQQAPWSLEDLPTKAALALHQGSTVTSMEFYPMQNTLLLVGSATGEITLWELAARERLVSRPFKIWDMSNCSHQFQALIAKETPISVTRVAWSPDGNFIGVAFTKHLIQLYAFSGPNDLRQHTEIDAHVGAVNDLAFANPNRQLCVITCGDDKLIKVWDVSGRKHFTFEGHDAPVYSICPHYKENIQFIFSTAIDGKIKAWLYDNLGSRVDYDAPGKWCTRMLYSADGTRLFSCGTSKDGDSFLVEWNESEGSIKRTYKEFQKKLAGVVQFDTSKNHFLAVGEDGQIKFWDMNNINVLTSTDAEGGLPALPHLRFNKDGNLLAVTTADNGFKILANPAGFRSLRAMETPASETMRTPVDFKAVPGAPVASVNCKVERGSPVRHSQMLNGVDPSKSRIDDSTDKPKSWQLAEILDPSQCFQATLPDTAGSSTKVVQLLYTNSGAGILALGSNGIQRLWKWVPNEQNPSGKATATVVPQHWQPNSGLLMTNDVSGVNLENAAPCIALSKNDSYVMSAAGGKVSLFNMMTFKVMTTFMPPPPASTFLAFHPQDNNVIAIGMEDSTIHIYNVRVDEVKSKLKGHQKRITGLAFSTALNILVSSGADAQICFWSIDTWEKRKSVAIQMPAGKAANGDTRVQFHVDQLRILVVHETQLAVFDASKMECIRQWIPQDSLSAPISSAVYACNSQLIYTTFRDGNIGVFDADSLRLRCRISPSAYLPQGNQGLSPLVVAAHPQDPNQFAVGLNDGSVKMMEPTEGEGKWGMIPPSEAINSPSTTSNQTPEQLQR
What is the function of this protein?
Transcriptional corepressor.  Negative regulator of jasmonate responses (By similarity).
What are the official names of this protein?
Topless-related protein 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: TUS_ECO8A
Sequence: MARYDLVDRLNTTFRQMEQELAAFAAHLEQHKLLVARVFSLPEVKKEDEHNPLNRIEVKQHLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQVDNLSQAALVSHIQHINKLKTTFEHIVTVESELPTAARFEWVHRHLPGLITLNAYRTLTVLHDPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVAPWTREEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQVQHACPTPLIALINRDNGARVPDVGELLNYDADNVQHRYKPQAQPLRLIIPRLHLYVAD
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHD_BACC1
Sequence: MKEIEKLKEEYPLLNKLIATEEVFWVNPNMEKYETAIKDSPLNEENVKDAEERLKRFAPYIAKVFPETKETNGIIESPLVKIPSMKQALEKNYEQPILGELLLKCDSHLPISGSIKARGGIYEVLKHAEQLALQYGMLTEEDDYSILDSDTCREFFATYSIAVGSTGNLGLSIGIMSAKLGFNVTVHMSADAKQWKKDLLRSKGVNVIEYEADYSKAVEEGRRQADADPSCYFVDDENSHDLFLGYAVAASRLQKQLEELEIVVDEEHPLFVYLPCGVGGGPGGVAFGLKLLYKDNVHCFFAEPTHSPCMLLGLMTGLHDKIAVQDIGIDNVTDADGLAVGRPSGFVGKTIEPFLSGNYTVSDEELYRLLKELADTEKIYLEPSALAGMIGPVKVCAEDEYLQKQQLTEKMKKGTHIVWGTGGSMVPEDVMNGYYKKGLELIL
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: CHK2_CAEEL
Sequence: MVRGTKRRRSSAEKPIVVVPVTRDDTMPVDEDLVVGESQCAASKPFAKLVGVRRGISSIDLADDHFVCGRGSDDAPTNFNFSQVAKDVGLYRFISKIQFSIDRDTETRRIYLHDHSRNGTLVNQEMIGKGLSRELMNGDLISIGIPALIIFVYESADADHHPEELTKKYHVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDKAERCILKLTDFGMAKNSVNRMKTRCGTPSYNAPEIVANEGVEYTPKVDIWSLGCVLFITFSGYPPFSEEYTDMTMDEQVLTGRLIFHAQWRRITVETQNMIKWMLTVEPSNRPSAVELMSTQWMKCADCRTAKQDILKSIKPISAAAPAALQTTQAGPVKKAKM
What is the function of this protein?
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks.  May also negatively regulate cell cycle progression during unperturbed cell cycles.  Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis.  Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase.
What are the official names of this protein?
Serine/threonine-protein kinase chk-2, Ce-cds-1, Ce-chk-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS17_RICFE
Sequence: MRNIKMPKRVLQGVVISSKADKTVTVKVERKFKHPIYKKFVKVSKKYAAHDSENKYQEGDKVSIIESRPISKTKTWLVVNGE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: SYP_PSE14
Sequence: MRTSQFLLATQKETPSDAVVVSHQLMLRAGMIRKLASGLYTWLPMGLRVLRKVEAIVREEMDAAGALEILMPGIQPAELWQESGRWEQYGPELMRLVDRHNREFCLGPTHEEVITDLARNELNSYKQLPINMYQIQTKFRDEIRPRFGLMRGREFVMKDAYSFHADHASLQVTYDRMHLAYSNIFTRLGLKFRPVEADNGSIGGAGSHEFHVLAESGEDDIVFSDGSDYAANIEKAEAVPREKARPAATEELRLIDTPNAKTIAQLVEGFDLPIEKTVKTLVVHAAEEGKLIALIIRGDHELNEIKASQLEQVASPLVMASEAELRDAIGAGAGSLGPLNLPLPCIIDRSVELMSDFSVGANIDDKHYFGVNWERDLPVPTVADLRNVVAGDPSPDGKGTLEIKRGIEVGHIFQLGTKYSEAMKCQVLGENGKPVNLAMGCYGIGVSRVVAAAIEQNSDENGIIWNDTLAPFQIALIPLRYETDAVREATDKLYAELTAAGFEVLLDDRDKKTSPGIKFADMELIGIPHRIVVSDRGLAEGNLEYKSRTESQPQAIAVADVLSFIQGKVNR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIF3F_DICDI
Sequence: MQKETSIFLPSQVTVKVHPVVIFNILDHYIRRNVGQDRVIGTLLGFNNDGVLEIRNCFPVVHSETEQIAVEMEYQRKMLDLHLKSSPREPIIGWYATGNDINENSVHINNFYRDEMGNSTPIHLTVDTGLTNDTMGIHAYMAHNLSLNPESSLGSYFSQLPLEILTFEAENAGLESIAQTKYDQQSTSLLSELESLQGSLTKLDEMLESITSYIESVEKGEIQGDPRLGRFLAKTIQALPKANAQVMDKVINNSVKDLLMIVYLSSLTRSQLAVATKISHSLSN
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit F, eIF3f, Eukaryotic translation initiation factor 3 subunit 5.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit F family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FENR_STREM
Sequence: MQERTYDITIIGGGPVGLFAAFYAGLRGMTVKIIESLSELGGQPAVLYPEKVIYDIPAYPALTGAELTQKLIEQLSRFDDRIAVCLKEEVLSFEKVDGDFVIQTSKARHYSKAIIVACGNGAFAPRTLGLDNEQLFADHNLFYNVHSLNQFAGKRVVICGGGDSAVDWALALDGLAKSVTLVHRRDAFRAHEHSVELLKNSHVTTLTPFVPLALEGENGFVNKMTIQKVKSEEEITLELDSLIVSFGFSTSNKNLKHWNLDYKRSSLLVSPLFQTSQEGIFAIGDAAAYEGRVDLIATGFGEAPIAVNQAIKYIYPDRDNRPVHSTALID
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: SNX3_CANAL
Sequence: MSKPFQPISDVINTSPKNKSQSFNEIYGEPENFLEIEVKNPLTHGYGSNLFTDYEIVCRTNIPAFKKRESRIRRRYSDFVAFRKILEQETTRVIIPPLPGKIFLNSNKFNDLNIEKRRQGLEKFLIVVSGHPLLQTGSKSLIEFIQNEKWDPKQIIY
What is the function of this protein?
Required for retention of late Golgi membrane proteins.  Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment.  Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
What are the official names of this protein?
Sorting nexin-3.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y4JE_SINFN
Sequence: MTRPAVSYDELDEYLRGDGHNDYVGVSAIDGLIAAVVAGPVTILPDIWLPHVFGGSMPQARPGSIEERLVNTVLNRHDEVESLLRDAPGHYYPIFMNHKGKTIVGPWAIGFSLGLSLGGEAWAPIAGNAKASDLPHHGRQSAAGQTAHPAFSSGAAEIESNRSSSHHIRSPAVARHHKTGPITTQPPAQTQPYRKTACSLRLQCTRSVEHDTQARGGPCIPGVSGLKLGLRPADRWSGCRWEHVVAYLGSPLYESTSTCAEGADRQLLVLRED
What are the official names of this protein?
Uncharacterized protein y4jE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AROK_PSET1
Sequence: MAEKRNIFLVGPMGAGKSTIGRHIADQLHLEFVDSDQEIERRTGADIAWVFDLEGEEGFRLREESVIGDLTEMQGIVLATGGGSVMSKEVRNKLSARGIVVYLETPIEKQVARTQRDKRRPLLQTEEAPRDVLERLAEEREPLYKEVADFVVRTDEQSAKVVANQIIEKLDF
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_NITOC
Sequence: MRTPLVVGNWKMNGSRAANRALLESMRKEMEAGVTAEVAVCPPFVYLADMESLLQGSVINWGAQNLSHHEVGAYTGEIAPSMLADLGCRFVIVGHSERRTLYGETDSLVAEKAIVAQKVNIIPIICVGETLQEREQNITEQVVKRQLNAVLELAGVNALEKAVIAYEPIWAIGTGRTATPEQAQEVHALIRSHVAIQNSGIAEELLILYGGSVKGNNAAELLAMPDIDGGLIGGASLDAKEFLTICQAAG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_CAUVN
Sequence: MTNAITGAAIVGGVCGQPIKHSMSPVIHNAWIAAAGLDAAYVPFAPAADRFETFVDGLRGGAVRGLNVTIPFKERALAVADTASDLARMAGAANLLVFNEDGSVHADNTDGPGLLGAIAIQAPGFDVTAAPVVILGAGGAARGAVAALLLAGAPRIAVVNRTVARAQDLADTFGEKVVAKGEDALPALLPEAGLIINATSLGLGGGAGPSADLTLTPKTAVVMDMVYKPLRTEFLRRAEAAGRRTVDGLEMLLRQAIPTFETIYGQAPSPKIDVRVLALKLLGEV
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: GRPE_ACTP7
Sequence: MTAQNENAQAQAEQVEVANEAQLEQTAEVQQEQPVEAELAAAYARINELETYVAEADNREKDIQLRAQAEIQNIRRRAEQDIEKAHKFALEKFSKELLTVVDNLERGLNALDTAVTDEKTQALVDGVEMTHKEFISTLAKFGVEAVGVVGEAFNPEVHEAISMQPAEGIEANHISVVLQKGYTLQGRVLRPAMVMVAG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDFL_BACSU
Sequence: MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYYSTQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIERKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVNEDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGSHPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YdfL.
Protein: AROQ_SYNSC
Sequence: MHVLLLNGPNLNLLGQREPGIYGHSSLADIEAALTREAEQESVQLDCFQSNFEGALVDRIHQAMGRCDGILINAGAYTHTSIAIRDALAGVAIPYVEVHLSNTHARENFRHHSFLAERAVGVICGFGPASYSFALNGLLSHLRRNA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: SIRT_LEPMC
Sequence: MATCPSIFDALVIGAGPAGLSAALALGRVMRTAAIFDTGVFRNAPANHMHTVPTWDHQSPVAYRQQCITELRQRYNGTIHFANTGVASVKAGKDSDYVVTDEAGKTWMGRKVILATGVKDVMPDVKGYAQAWGRYIFHCLFCHGFEQRGSESAGLLVLDKTILSTEIEIAVHFGHLALQFAKKITVFLDGHVEFLEDPRIKGLEAQGFLINPKPISKITYAADPEPGFATVHLEDGSEENMSFLVHRPRTLLAGDFANQLGLELTEAGDVKTTPPFYETSVKGVFAAGDCAVPLKQVVWAVSTGVSAGSGVNFQCLGADMAARSKLS
What is the function of this protein?
Thioredoxin reductase; part of the gene cluster that mediates the biosynthesis of sirodesmin PL, an epipolythiodioxopiperazine (ETP) characterized by a disulfide bridged cyclic dipeptide and that acts as a phytotoxin which is involved in the blackleg didease of canola (PubMed:15387811, PubMed:18272357, PubMed:19762440).  SirD catalyzes the O-prenylation of L-tyrosine (L-Tyr) in the presence of dimethylallyl diphosphate (DMAPP) to yield 4-O-dimethylallyl-L-Tyr, and therefore represents probably the first pathway-specific enzyme in the biosynthesis of sirodesmin PL (PubMed:19762440, PubMed:21038099, PubMed:24083562).  4-O-dimethylallyl-L-Tyr, then undergoes condensation with L-Ser in a reaction catalyzed by the non-ribosomal peptide synthase sirP to form the diketopiperazine (DKP) backbone (PubMed:18272357).  Further bishydroxylation of the DKP performed by the cytochrome P450 monooxygenase sirC leads to the production of the intermediate phomamide (PubMed:27390873).  This step is essential to form the reactive thiol group required for toxicity of sirodesmin PL (PubMed:27390873).  The next steps of sirodesmin biosynthesis are not well understood yet, but some predictions could be made from intermediate compounds identification (PubMed:18272357).  Phomamide is converted into phomalizarine via oxidation, probably by sirT (PubMed:18272357).  Further oxidation, methylation (by sirM or sirN) and reduction steps convert phomalizarine to deacetyl sirodesmin (PubMed:18272357).  Finally, acetyltransferase sirH probably acetylates deacetyl sirodesmin to produce sirodesmin PL (PubMed:18272357).
What are the official names of this protein?
Thioredoxin reductase sirT, Sirodesmin biosynthesis protein T.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
Protein: RS5_SHEB9
Sequence: MAKLEAQQKDDLQEKLIAVNRVSKVVKGGRIFSFTALTVVGDGNGKIGYGYGKAREVPAAIQKAMEKARRNIVTVELNAGTLHHPVKGRHTGSLVYMQPASQGTGIIAGGAMRAVLEVAGVHNVLSKAYGSTNPINIVRATVDALVHMKSPSQIAAKRGLNVDEIRG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RL34_ECO45
Sequence: MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PRSD_ECOLX
Sequence: LQIALQTKIKLFYRPAAIKTRPNEVWQDQLILNKVSGGYRIENPTPYYVTVIGLGGSEKQAEEGEFETVMLSPRSEQTVNRNYNTPYLSYINDYGGRPVLSFICNGSRCSVKKEK
What is the function of this protein?
Mediates assembly of pili by forming soluble multimeric complexes with pili subunits as an intermediate step in the assembly process.
What are the official names of this protein?
Chaperone protein PrsD.
What is the protein family that this protein belongs to?
Belongs to the periplasmic pilus chaperone family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PMT2_ARATH
Sequence: MALKSSSADGKTRSSVQIFIVFSLCCFFYILGAWQRSGFGKGDSIALEMTNSGADCNIVPSLNFETHHAGESSLVGASEAAKVKAFEPCDGRYTDYTPCQDQRRAMTFPRDSMIYRERHCAPENEKLHCLIPAPKGYVTPFSWPKSRDYVPYANAPYKALTVEKAIQNWIQYEGDVFRFPGGGTQFPQGADKYIDQLASVIPMENGTVRTALDTGCGVASWGAYLWSRNVRAMSFAPRDSHEAQVQFALERGVPAVIGVLGTIKLPYPTRAFDMAHCSRCLIPWGANDGMYLMEVDRVLRPGGYWILSGPPINWKVNYKAWQRPKEDLQEEQRKIEEAAKLLCWEKKYEHGEIAIWQKRVNDEACRSRQDDPRANFCKTDDTDDVWYKKMEACITPYPETSSSDEVAGGELQAFPDRLNAVPPRISSGSISGVTVDAYEDDNRQWKKHVKAYKRINSLLDTGRYRNIMDMNAGFGGFAAALESQKLWVMNVVPTIAEKNRLGVVYERGLIGIYHDWCEAFSTYPRTYDLIHANHLFSLYKNKCNADDILLEMDRILRPEGAVIIRDDVDTLIKVKRIIAGMRWDAKLVDHEDGPLVPEKVLIAVKQYWVTNSTSTH
What are the official names of this protein?
Probable methyltransferase PMT2.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: YACL_SALTI
Sequence: MDYEFLRDVTGRVLVRMSMGHEVVGHWFNEEVKDNLSLLDEVEQAARTVKGSERSWQRAGHEYTIWMDGEEVMIRANQLDFSGDEMEEGMSYYDEESLSLCGMEDFLRVVAAYREFVSKA
What are the official names of this protein?
UPF0231 protein YacL.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: NLPI_YERPN
Sequence: MKPFLRWCYVATALMLAGCSNHDWRKDEVLAIPLQPTLQQEVILARMEQILASRALTDDERAQLLYERGVLYDSLGLRALARNDFSQALAIRPDMPEVFNYLGIYLTQAGNFDAAYEAFDSVLELDPTYNYARLNRGIALYYGGRFPLAQDDLQAFYQDDPNDPFRSLWLYLVEREIDPKAAVVALQQRYEKSDRGQWGWNIVEFYLGKISEKSLMERLKADATDNTSLAEHLSETDFYLGKHYLSLGDKNTASVLFKLTVANNVHNFVEHRYALLELALLGQEQDDLSESDQQ
What is the function of this protein?
May be involved in cell division.  May play a role in bacterial septation or regulation of cell wall degradation during cell division (By similarity).
What are the official names of this protein?
Lipoprotein NlpI.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ATPE_STAEQ
Sequence: MNTLRLNIVTPNGSVYEREDVEMAVLQTTAGEMGIMYGHIPTVAALKTGHVKVNFHNGNEFIAVSDGFIEARQHQLSIIVQTAEPASEIDVERAKLAKSRAESHLEEDDDNTDINRAKRALERANNRLRVAELQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HOG1_ZYGRC
Sequence: MATHEEFIRTQVFGTVFEITNRYTDLNPVGMGAFGLVCSATDTLAGQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFSEMIEGKPLFPGKDHVHQFSIITDLLGSPPRDVINTICSENTLKFVTSLPHRDPVPFQERFKTVEPDAVDLLERMLVFDPKKRITAADALVHPYLAPYHDPTDEPTAEAQFDWDFNDADLPVDTWRVMMYSEILDFHKIGGGDGQIDTNAAFDDQVAAATAAAAHAAAMAQHHHQTQQQSSGKHTNPTTSSSAATHNSNGPHSNHDAIANYGNQAVHYANEFQQ
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase HOG1, MAP kinase HOG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.