PharMolix/UniProtQA huggingface dataset:
Protein: TM160_HUMAN
Sequence: MGGGWWWARAARLARLRFRRSLLPPQRPRSGGARGSFAPGHGPRAGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGFFLLGGLCVVWGSASYAVGLAALRGPMQLTLGGAAVGAGAVLAASLLWACAVGLYMGQLELDVELVPEDDGTASAEGPDEAGRPPPE
What are the official names of this protein?
Transmembrane protein 160.
What is the protein family that this protein belongs to?
Belongs to the TMEM160 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BPJ_BPP2
Sequence: MPIIDLNQLPAPDVVEELDFESILAERKATLISLYPEDQQEAVARTLTLESEPLVKLLEENAYRELIWRQRVNEAARAVMLACAAGNDLDVIGANYNTTRLTITPADDSTIPPTPAVMESDTDYRLRIQQAFEGLSVAGSVGAYQYHGRSADGRVADISVTSPSPACVTISVLSRENNGVASEDLLAVVRNALNGEDVRPVADRVTVQSAAIVEYQINATLYLYPGPESEPIRAAAVKKLEAYITAQHRLGRDIRLSAIYAALHVEGVQRVELAAPLADIVLNSTQASFCTEYRVVTGGSDE
What is the function of this protein?
Baseplate protein that may be part of the wedges of the baseplate.
What are the official names of this protein?
Baseplate protein J, Gene J protein, GpJ.
What is the protein family that this protein belongs to?
Belongs to the P2likevirus gpJ protein family.
What are the subcellular locations of this protein?
Virion. Note=Part of the baseplate.
Protein: GLYA_ALKMQ
Sequence: MNFDTLKKFDEEIYEVIQKETKRQRGSIELIASENFVTTAVMEAMGSQLTNKYAEGYPDKRYYGGCEEVDVAENLARNRLKKLFNAEHANVQPHSGANANIGVYFATLEPGDTVLGMNLSHGGHLTHGSPVNISGAYYNFVAYGVDSVTHRIDYEEVMRVAQEAKPKMIVAGASAYPRAIDFKKFREIADAVGAYLMVDMAHIAGLVAVGLHQNPCEYADFVTTTTHKTLRGPRGGAILCKEKYAKIIDKAIFPGLQGGPLMHVIAAKAVAFKEALEPGFKAYQEQVIKNAKALGEELKKQGFDLVSDGTDTHLLLIDLRNKNITGKDAERLFDEVGITVNKNTIPFDPQSPFVTSGIRIGTPAVTTRGMKEEEMKKIAGVMNIIIDHPEKVSEAQKVVDELCNQFKLYE
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_SHIB3
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVAIEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_XANOR
Sequence: MTASAPAASTSARLLDGRRIAEELLDGLKSRVDARLAAGKARPGLAVVLVGGDPASSVYVRNKRRAAEKVGIEAFDYDLPQCTSEAELAALIDELNADPKIHGILIQLPLPGIPDANRLIQRIDPRKDVDGFHPQNVGHLALREFGLRPCTPRGIVTLLSHTDQPVRGRNATIVGVSNHVGRPMGLELLIAGCTVTSCHKFTPPDVLEASVRNADILVVAVGRPGLIPGEWVKPGAVVIDVGINRLDDGRLVGDVGFDAAAQRAAWITPVPGGVGPMTVATLMQNTIEAADAAGIEGAGVGIR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: GEMI7_BOVIN
Sequence: MQTPLATPVPVLRLPRGPDGSNRGFAPDGRRAPPKPEVPEPPESRESWEQQARASLRERYLRSLLAMVGRPVCFTLHEGVQVIAHFGATDLDVANFYVSQLQTPIGIQAEALLRCSDIISYTFKP
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).
What are the official names of this protein?
Gem-associated protein 7, Gemin-7.
What is the protein family that this protein belongs to?
Belongs to the gemin-7 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, gem. Cytoplasm. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity).
Protein: RS12_THIDL
Sequence: MPTINQLVRQGAXAETIKSKSAAMENSPQRRGVCTRVYTTTPKKPNSALRKVAKVPLTNGFEVISYIGGEGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGSLDLQGVKDRKQSRSKYGAKRPKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: GRP1_XENTR
Sequence: MGTVGKKKDRPTHGCSTIPKLALELKQIIHSTTHPKVPPVTPLRVMMPLGKLSKGASLDDLIQMCIQAFDLDGNMGQNSELLQIMLTMHGFLLPSTELLMKLRTLYQDALQNRSFSFCLRICYFIRYWVTELWVMFKMDAKLTQAMEEFQELVRSKGEELHWRLIDTAQINSRDWSRKLTQRIKPNCSKKRKVSLLFDHLEPQELAEHLTYLEFKAFRRISFSDYQNYIVSGCVKENPTMERSIALCNGISQWVQFMVLSRPTPQLRAEVLTKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKDTSAHVSHDVNKVLNEMTELLSSCRNYDNYRRVYNECTNFKIPILGVHLKDLIALHEAMPDFLEDSKINVPKLHSLYNHINELIQLQNIAPPLEANMDLVHLLTLSLDLYYTEDEMYELSYAREPRNHRAPPVTPSKPPVVADWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRQEITAYFMRASSICSKLGLGFLHNFQETTYLRPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKELVVFECKKRSKLSVGENSSMFDSGQLEVIPAGGKGQTNDCLGAEEGPYSYPNGDGDIHTEVSKDRTIMLMGSSAQKISVRLQPAVKHRATQTENEPQSLCLQVPSPQRSRTPGLTSHLPISPMPSPCPSPVPTRKKAYAKWENKDSIRKARAELRGGKAGIQELEKEKALLKEENTTLKIQLKDAQRRVETLRAELRKYVLDSDVHQTGS
What is the function of this protein?
Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP.
What are the official names of this protein?
RAS guanyl-releasing protein 1.
What is the protein family that this protein belongs to?
Belongs to the RASGRP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes.
Protein: NORW_SALPK
Sequence: MSRGIIIIGSGFAARQLVKNIRKQDAHVPLTLIAADSMDEYNKPDLSHVISQSQRADDLTRQLAGEFAEQFNLRLFPHTWVTDIDADAHVVKSQDKQWQYDKLVLATGAAAFVPPIAGRELMLTLNNQQEYRACETPLRDAQRVLIVGGGLIGSELAMDFCRAGKTVTLMDNAASLLASLMPPEVSSRLQHHLTDMGVHLLLKSQLQKLEKIEAGIRATLASQRSIEVDAVIAATGLRPETALARRAGVVVNRGVCVDSYLQTSHPDIYAIGDCAEINGQVLPFLQPIQLSAMYLAKNLLGGNAPLKLPAMLVKVKTPELPLHLAGETQRRDLSWQITAESDGMIAKGMSGEGQLRAFVVSEDRMKEAFALLKTLSV
What is the function of this protein?
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase.  Reduces the rubredoxin moiety of NO reductase.
What are the official names of this protein?
Nitric oxide reductase FlRd-NAD(+) reductase, Flavorubredoxin reductase, FlRd-reductase, FlavoRb reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSN_SHIDS
Sequence: MNTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLMDYSEETFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESMPWYSGPTLLEVLETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSGVESNVARIVTFDGDREEAFAGEAITLVLTDEIDISRGDLLLAADEALPAVQSASVDVVWMAEQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLTQREVENLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDRLSNVTVGAGMVHEPVSQATAAPSEFSAFELELNALVRRHFPHWGARDLLGDK
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: CLS_STAAW
Sequence: MIELLSIALKHSNIILNSIFIGAFILNLLFAFTIIFMERRSANSIWAWLLVLVFLPLFGFILYLLLGRQIQRDQIFKIDKEDKKGLELIVDEQLAALKNENFSNSNYQIVKFKEMIQMLLYNNAAFLTTDNDLKIYTDGQEKFDDLIQDIRNATDYIHFQYYIIQNDELGRTILNELGKKAEQGVEVKILYDDMGSRGLRKKGLRPFRNKGGHAEAFFPSKLPLINLRMNNRNHRKIVVIDGQIGYVGGFNVGDEYLGKSKKFGYWRDTHLRIVGDAVNALQLRFILDWNSQATRDHISYDDRYFPDVNSGGTIGVQIASSGPDEEWEQIKYGYLKMISSAKKSIYIQSPYFIPDQAFLDSIKIAALGGVDVNIMIPNKPDHPFVFWATLKNAASLLDAGVKVFHYDNGFLHSKTLVIDDEIASVGTANMDHRSFTLNFEVNAFIYDQQIAKKLKQAFIDDLAVSSELTKARYAKRSLWIKFKEGISQLLSPIL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL7_MYCGA
Sequence: MAKLTKEQFIESLKEMTIVEINDVIKAIEEAFGVSAAAPIAAAAAAPAAAAPTEATVVLVSAGDKKVEVIKLVREVTGLGLMDAKKAVDTPPATIKENMNIEEAKALKAKFEAVGAKVDLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: INP4B_MACFA
Sequence: MEIKEEGASEEGQHFLPAAQASDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLALSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVRGQKCALVCECTAPESVSSKGEKTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLVATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGVLKKPPSPKSSTEESSPQEQPPLMRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGSNNDGEKEPSLADSIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVVTGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLHQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT
What is the function of this protein?
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity).  Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity).  The lipid phosphatase activity is critical for tumor suppressor function.  Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity).
What are the official names of this protein?
Type II inositol 3,4-bisphosphate 4-phosphatase, Inositol polyphosphate 4-phosphatase type II.
What is the protein family that this protein belongs to?
Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
Protein: FABZ_NEIMB
Sequence: MDVQLPIEAKDIQKLIPHRYPFLQLDRITAFEPMKTLTAIKNVTINEPQFQGHFPDLPVMPGVLIIEAMAQACGTLAILSEGGRKENEFFFFAGIDEARFKRQVIPGDQLVFEVELLTSRRGIGKFNAVAKVDGQVAVEAIIMCAKRVV
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_BURPS
Sequence: MKVAVLGAGAWGTALAAHLAVRHDTLLWARDAALVAELAARRENARYLGGVALPPGLRYEADLATALSHAQADDALCVIAAPVAGLRALCRAMRDARRVPAHFVWVCKGFEADTRRLPHQMVAEELPDHASYGVLSGPSFAREVAQGLPVALTVASASAACRERTLAAFHHGAMRIYTGDDVVGVEVGGAVKNVLAIATGIADGLGLGLNARAALVTRGLAEMSRLGVALGGRAETFTGLTGLGDLILTATGDLSRNRSVGLQLAAGRSLDDILAALGHVAEGVRCARAVLSIARERGVDMPITEAVCAVLFDGVAPRDAVSGLLRRDAKAE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_ENTFO
Sequence: MQLRTNVKHLQGTLMVPSDKSISHRSIMFGAISSGKTTITNFLRGEDCLSTLAAFRSLGVNIEDDGTTITVEGQGFAGLKKAKNTIDVGNSGTTIRLMLGILAGCPFETRLAGDASISKRPMNRVMLPLNQMGAECQGVQQTEFPPISIRGTQNLQPIDYTMPVASAQVKSAILFAALQAEGTSVVVEKEKTRDHTEEMIRQFGGTLEVDGKKIMLTGPQQLTGQNVVVPGDISSAAFFLVAGLVVPDSEILLKNVGLNQTRTGILDVIKNMGGSVTILNEDEANHSGDLLVKTSQLTATEIGGAIIPRLIDELPIIALLATQATGTTIIRDAEELKVKETNRIDAVAKELTILGADITPTDDGLIIHGPTSLHGGRVTSYGDHRIGMMLQIAALLVKEGTVELDKAEAVSVSYPAFFDDLERLSC
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_SACD2
Sequence: MAKKSMIARETKRAKTVEKYAAKRAELKAIINNHESSDDQIWEAQLKLQKLPRDASPSRQQRRCRITGRPHAVYRKFGLCRNKLREAAMRGDVPGLVKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ORYJ_ASPOR
Sequence: MGSLPEKDFPQVHRFITTHKEDGTPTFETKIPEPIEWERTNIGVDFFLAYTLGSFPAPLSHDADLNQYKDHLVNHPPFMIPGGAVVRYVDYHPGCEPMWHRTVTVDFGVVIEGELELEVEGGEKRLMKRGDVAVQRGTNHCWRNPSKTQFARALYIALDAKPVIVNGQELGESLGEVKH
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of oryzines, natural products with an unusual maleidride backbone (PubMed:30104550).  The two subunits of the fungal fatty acid synthase oryfasA and oryfasB probably form octenoic acid (Probable).  This fatty acid is most likely activated by the acyl-CoA ligase oryP to give octenyl-CoA before the citrate synthase-like protein oryE catalyzes condensation with oxaloacetate to form tricarboxylic acid (Probable).  The next steps of the pathways are conjectural, but a favorite possible route has been proposed, beginning with decarboxylation and concomitant dehydration by the decarboxylase oryM, followed by tautomerization, which may lead to the production of a diene intermediate (Probable).  Reduction of this diene intermediate could give the known metabolite piliformic acid (Probable).  On the pathway to oryzine B and oryzine A, however, hydroxylation of the diene by the alpha-ketoglutarate-dependent dioxygenase oryG and lactonisation by the lactonohydrolases oryH or oryL could give oryzine B directly (Probable).  Finally, enoyl reduction by the dehydrogenase oryD would then convert oryzine B into oryzine A (Probable).
What are the official names of this protein?
Oryzines biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the oryJ family.
Protein: S12A3_PSEAM
Sequence: MELPGDGVHLASYGPRAPQLAVNGKAPAGGLDGSGYYQCYRDGSSVASRGSDAPTGYDTVDAPPHYDFYANTEVWGRRRRVRPSLYQLSVDPEQDDFKPPMYEETAGERMGGGDSSEEEEEEHKEPPPEPPRFGWVQGVMIRCMLNIWGVILYLRLPWITAQAGIGLTWVIILLSSFITGITGLSTSAIATNGKVKGGGTYFLISRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETVTDLMRENGVVMVDPINDIRIVGVITVTCLLGISMAGMEWESKAQVLFFLVIMVSFVNYIVGTIIPASPQKQAKGFFSYKAEIFAANFVPGWRGKEGSFFGMFSIFFPSATGILAGANISGDLKDPTVAIPRGTLMAIFWTTISYLIISATIGACVVRDASGELNDTLSYSSSSENCSGLACQYRWDFSECIKNNTCKHGIMNYYQSMSLVSAFAPLISAGIFGATLSSALACLVSAPKVFQCLCKDQLYPLIGFFGKGYGKNAEPLRAYLLTYVIAVCFVLIAELNTIAPIISNFFLCSYALINFSCFHASVTNSPGWRPSFRFYSKWLSLLGAVCCVVIMFLLTWWAALIAFGVVFFLLGYTLYKKPAVNWGSSVQASSYSMALNQCVGLNQVEDHVKNYRPQCLVLTGPPCCRPALVDLVGCLTKRLSLMMCGHVVTAGPSPVSERHVTWLNQRKVRSFYRGVVAADLRSGVNMLLQGAGLGRIKPNVLLMGFKKDWGCDSPQAAHHYIGILHDAFDLHYGVCVLRVKEGLDASHPPQCHVNPGFDGGPESINTVCAPACVQTSVTSSVSMDPDPQPSSVFQKKQGKKTIDIYWLSDDGGLTLLLPYLLTRRKRWAGCKVRVFVGGDTDKKEEQKEEVLALIKKFRLGFHDVEVLPDIHQPPQPGNVDHFEDSVNRFRLETNPKQDSDSGPQQQQQEEPWMITEQDLERNRAKSLRQIRLNEVLQVHSREAALIVITMPVGRRGVCPSTLFLAWLDVLSRDLRPPVLLVRGNQENVLTFYCQ
What is the function of this protein?
Electroneutral sodium and chloride ion cotransporter, with a coupling ratio 1Na(+):1Cl(-).  Mediates sodium and chloride reabsorption.
What are the official names of this protein?
Solute carrier family 12 member 3, Na-Cl symporter, Thiazide-sensitive sodium-chloride cotransporter.
What is the protein family that this protein belongs to?
Belongs to the SLC12A transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LIPB_SPHAL
Sequence: MPSLPVPQWIVSPGLTDYAAALADMESRAAAIHADEAGERIWLLEHPPLYTAGTSADPAELLDPRFPVYDAGRGGRYTYHGPGQRVGYVQLDLTRRGRDVRAYVHALEGWVIDALALLGVKARRAEGRIGIWTDDVRGREAKIGAIGVRVKRWVTLHGFSLNVAPDLTHFTGIVPCGIAEYPVTSLAALGKATGFSEVDAALARTLPAFLDKLRPSD
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_LEGPL
Sequence: MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEEALLDKRADLAVHSTKDMPAQLPDGLSLAAICKRDNPFDALISPQFKSLDALPKNAIIGTSSLRRQSQLLAYNPNLQVKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIYGLNDPISALCVHTERRVNAKLGGNCHIPFAVYCTITAENLLLLRAKVLNLDGSQMIDDEQQGKIEEAEIIADRCTESLMTKGAMTLLSTIPS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: Y1209_PYRHO
Sequence: MQFNNKPLIGVVHLPPLPGSPGYKGELDEVIDRAISDAAKYQEAGFDAIILENYGDFPYSKTVGKETVSAFSVVANEVKREIALPLGINVLRNDCIAAYSIAYSIKADFIRVNVLTGVAFTDQGIVEGCARELAELRTRLPSRIDVLADVHVKHATHFSNFENALLDTIERGGADAVIVTGSRTGSEVDIQELITAKRISPVPVLVGSGVNPRNIKLFWRYSDGFIVGTWVKEGGRTINEVSIERATKLAKLVKSLREG
What are the official names of this protein?
Uncharacterized protein PH1209.
What is the protein family that this protein belongs to?
Belongs to the BtpA family.
Protein: NDHK_THEVB
Sequence: MTNTTSPAILNPIARPEVPQELAENIILTSLNDVYDWARLSSLWPLMYGTACCFIEFAAMIGSRFDFDRFGLVPRNSPRQADLIITSGTITMKMAPALVRLYEQMPSPKYVIAMGACTITGGMFSSDSYSAVRGVDKLIPVDVYLPGCPPRPEAIMDAIVKLRKKIANEHINERGNLAQTHRLFTAKHKMKPVPPILTGQYLNAPSRQAPPPALAAAMGIAVPALGEAVSETTSVAE
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, NAD(P)H dehydrogenase I subunit K, NDH-1 subunit K, NDH-K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SDS23_PICST
Sequence: MSNPPFQRQQPSSPLTTPNHHPSNHQHHASRKPSIVELLSSPPPLPNNTIDDEIHQFSLSRNTSISSRTSSFSQQQHGAPHHGSNSHHLSVSGMDWSEIPLSELTESNKLIYINSSYSVQKAFETLVSNNLTSVPVSISSSNENDLSSCLTFDYSDLNTYLLLIMNKINLSELSVSEIGNEHDSTAKKHEIITQTINKAKRGEEVPIEFIIKLHPKNPFIKFTENDTLFKVMETLGNGVHRVAITNLESTKITGILSQRRLIKYMWENARRFPSLDFYLNSTLQDLKIGSSTPIFIYEDQLLIEALYKMFNERVSSLAVIDRTKSLIGNISIVDVKNVSSSKNSHLLFKSVLTFISYNLSQKGIEEGQDQYPIFHVNKQSSLGRVIAKLVATQSHRLWIVESNTRTHQNSISSPVTIEATLNVSANPSSASSSNANTPEGNFGLPGKLIGVVTLTDILGLFATSKGTKTDPQFARNQRRRSSTSTTRSSIDSAISVGDGSARTTNANADSEIFRKSYTAAAKNESAISKD
What is the function of this protein?
Involved in DNA replication and cell separation.
What are the official names of this protein?
Protein SDS23.
What is the protein family that this protein belongs to?
Belongs to the SDS23 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NIFE_METMI
Sequence: MVLNLDTENRKMQDGNNDDDFDLEVQIPNSIFEKLKSIEALKARESPMCVSGKDDSIPTCDQNSTPGMITQRSCVYGGARVVLMPITDAVHLVHGPIGCAACTWDIRGSKSTGDKLYKNGFSTDLQEKDIVFGGEKKLYESILEVNKLYHPGAIFVYSTCVVGLIGDDLKAVCRQAQEATGCRVIPVQSEGFKSFNKTAGHKLACDAMLDYVIGTEEPEEEHPYSINIIGEFNVAGDLWGIIPLYEKMGVKVHTAITGDSTVAKVASAHRSKLNIVQCPKSSNYLAAQMDKKYGIPSFKVNFFGLDETTKSLRAVAEFFGDEEMIKRTEELIKSEIKNLRDEISEYQKDLSGRTVAIYSGAHKSWALVSAFGELDMEIIMSGTQNGKPEDYQQIRDHVCEGTLIVDDASSMELVQLLKEYKPDILISGAKEKYLSLKSGIPHCDFNHDRITAFSGYQGFINFARVVHTAVMTPIWRLSRKMMI
What is the function of this protein?
This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).
What are the official names of this protein?
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.