PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_HALOH
Sequence: MASKVEQEIRDLREKIRYHEYRYYVLDDPEISDAEFDELIQRLIDLEEKHPGLVTPDSPTQRVGGEPLDKFDKVEHRVPMLSLGNAFNEGDLTNFARRIYRLLDTGKIDFVVEHKIDGLSAILTYQGGRLIRGATRGNGVVGEDVTANIKTIPSVPLRLKKDVDIEVRGEVYIKKDDFSKLNERRLKKGEEPFANPRNAAAGSIRQLDPRLAAARPLSFIAYDVVAYEGEGLQTHVGALELLRELGFKVNWYRKCDDITEVVNICKDWVDKREELPFEIDGMVIKVNELGLREQLGATAKSPRWAIAYKFPAQQKTTVVKDIIISVGRTGALTPTAVLEPVEVDGSTVSRATLHNEDEIRRKDVRIGDHVLVQKAGDVIPEVVKVIKSKRDGSEQIFHMPETCPACGGEVVREEGEAVLRCVNVTGCPAQRREGILHFVSRNAMNIDGVGPALIDQLLEKGLIEDYADLYYLKKEDLIPLERMGEKSATNAIEAIRASKDRPLFRVIFALGIRHVGLGVARVLTEKYRSLSDLMRASGEELVAIDEIGPTIARSIIEFFKEPHNREVINKLKEAGVRLEEKENGKEEQNLYLSGKTFVFTGKLDGFTRSEARDKVIAAGGKVTSSVSRKTDYVVVGDSPGSKYDKARELGVTILDEDKFKEVLKAGDNNG
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PP309_ARATH
Sequence: MHLPSSSSLYSSPTKSLFAMFLKARALSVTTQNPPDLFSLLHHSPNAKHLRHLHAHLLRTFLYSNVVLSSKLVLAYSKLNHLFPTSLSVFWHMPYRNIFSWNIIIGEFSRSGFASKSIDLFLRMWRESCVRPDDFTLPLILRACSASREAKSGDLIHVLCLKLGFSSSLFVSSALVIMYVDMGKLLHARKLFDDMPVRDSVLYTAMFGGYVQQGEAMLGLAMFREMGYSGFALDSVVMVSLLMACGQLGALKHGKSVHGWCIRRCSCLGLNLGNAITDMYVKCSILDYAHTVFVNMSRRDVISWSSLILGYGLDGDVVMSFKLFDEMLKEGIEPNAVTFLGVLSACAHGGLVEKSWLYFRLMQEYNIVPELKHYASVADCMSRAGLLEEAEKFLEDMPVKPDEAVMGAVLSGCKVYGNVEVGERVARELIQLKPRKASYYVTLAGLYSAAGRFDEAESLRQWMKEKQISKVPGCSSI
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At4g14170.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
Protein: CL033_HUMAN
Sequence: MRRCRRCARWPHRCPGPQSGPRSHFSPWPRTLGPAPALCVRTPLRPGPSSALGPLSACPSVPDYTASPPAGDSARSIVAASRAAGSGSTPGAGSKDCSPPPHSHSAAAAGESGDIGPGSGAVEAPGRGARRPTRQREDGGGAVGCFGVSRHRGREAQMSHSSHCGSRSCSAAAARPSLLQLA
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC00612.
Protein: SYR_NITHX
Sequence: MTNPGPSRHLFADVLARVHAVCSALVEEGALPAGLDLSRIVVEPPREASHGDMATNAAMVLAKGAKSKPRDLAEKVAAKLRADGLIDKAEIAGPGFINLTLKPQVWSDALRTVLREGDGYGRSAIGAGEKVNVEYVSANPTGPMHVGHCRGAVFGDALASLLSFAGYGVTREYYINDAGAQVDVLARSAYLRYREALGQDIGEIPEGLYPGDYLKPVGQALAAEHGDSLLKAPEAEWLPVARAKAIAMMMEMIKGDLAALNIQHEVFFSERSLIEGGSDRVAATIDFLRAKGDVYEGRLPPPKGAPVEDYEDREQTLFRATAYGDDIDRPLKKSDGGYTYFASDIAYHKTKFDRGFLNMVDVWGADHGGYIKRVQAAIKAVTSGKATLDVKIVQLVKLLRNGEPVKMSKRSGDFVTLREVVDEVGSDAVRFMMLFRKNDAVLDFDLAKVIEQSKDNPVFYVQYGHARGFSIFRNAREAFPDLPEDASKRAAFLAAAAVERLTDPAELGLLRRLALYPRTVEAAALAHEPHRIAFYLYDLASEFHALWTKGRDMPHLRFIINNDAVITRARLALVQGVVSVLASGLAVLGVHAPNEMR
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_AERS4
Sequence: MDVADLRREYTRGGLHRADLPADPLALFEKWLAQACEAKLTDPTAMVVATVDAEGQPWQRTVLLKHYDAQGMVFYTNMGSRKAHQLEGNPRISLLFPWHTLDRQVHVTGRVEKMSTFEVMKYFHSRPKDSQIAAWVSKQSTRISARGVLEAKFLELKQKFANGEVPLPSFWGGYRVVIDTVEFWQGGEHRLHDRFYYTREGDGWHIERLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: SOJ_BACSU
Sequence: MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGNATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTISREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQLLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVRLSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG
What is the function of this protein?
Inhibits the initiation of sporulation, Spo0J antagonizes this inhibition.  Soj ultimately inhibits the activation (phosphorylation) of Spo0A.
What are the official names of this protein?
Sporulation initiation inhibitor protein Soj.
What is the protein family that this protein belongs to?
Belongs to the ParA family.
Protein: RS4_BORT9
Sequence: MNRKNIAKGKLVRRFGVNIFEQPKYDKLLKKKPNAPGMHGRSRRAKITEYGKQLIEKQKVKFTYGVSERQLTNIFKESRRQHGVTGDNLLALLERRIDNVVYRAGFAISRAHARQIVSHGIIMLNGRRVTIPSITLRANDMIQVKEKDRLKKLVRSNIEKTSTLRKLPTWIEVNADDLNVKITRPPSRDEIPTLANEQMIVEYYSKRA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: LRK61_ARATH
Sequence: MGIARSINSFMFFFFLMILSNASKSSVLAEATTAKFTFIGFKENQTDIQTEGASTIQHDNDLLRLTNRKQNVTGTAFYRKPIRLRELTNSSDIKVCSFSTSFVFVILPSSPGNGGFGFTFTLSPTPNRPGAESAQYLGLLNRTNNGNPSNHVFAVEFDTVQGFKDGADRRGNHIGLNFNNLSSNVQEPLIYYDTEDRKEDFQLESGEPIRVLIDYDGSSETLNVTIYPTRLEFKPKKPLISRRVSELSEIVKDEMYVGFTAATGKDQSSAHYVMGWSFSSCGENPMADWLEISRLPPPPRLSNKKGYNSQVIVLIVALSIVTLVLLVLLFIFVMYKRRIQEEDTLEDWEIDYPHRFRYRDLYLATKKFKESEIIGTGGFGIVYRGNLSSSGPIAVKKITSNSLQGVREFMAEIESLGRLGHKNLVNLQGWCKHKNELLLIYDYIPNGSLDSLLYQTPRRNGIVLPWDVRFEIIKGIASGLLYLHEEWEQIVVHRDVKPSNVLIDEDMNAKLGDFGLARLYERGTLTQTTKIVGTLGYMAPELTRNGKGSTASDVFAFGVLLLEIVCGNKPTNAENFFLADWVMEFHTNGGILCVVDQNLGSSFNGREAKLALVVGLLCCHQKPKFRPSMRMVLRYLNGEENVPQIDENWGFSDSSRDDHKSNVVGYVSSDRASSSNTFSSFSNVSSSSIVSGR
What are the official names of this protein?
Probable L-type lectin-domain containing receptor kinase VI.1, LecRK-VI.1.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RL22_BACCN
Sequence: MQAKAVARTVRIAPRKVRLVVDLIRGKQVGEAIAILNHTPKTASPVVEKVLKSAIANAEHNYEMDVNNLVVEKVFVDEGPTLKRFRPRAMGRASQINKRTSHITVVVSEKKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: FBIA_THEFY
Sequence: MRIVVLAGGIGGARFLRGLKDALHHRAEQGESPSSITVIGNTGDDITLFGLRVCPDLDTVMYTLGGGINEEQGWGRADETFTVREELIAYGMHPQWFGLGDRDIATHIVRSQMLAAGYPLSAITEALCDRWKPGVRLLPMTDDQVETHVVVADEKGRRAIHFQEWWVRYRAQIPAESFVSVGADSAKPAPGVLSAIDEADFVLFPPSNPVVSIGSILGIPGIRDAVAAKTVVGVSPIIGGAPVRGMADACLRTIGVETSARAVAEHYGADLLDGWLVDEADADTVVAGVEVRAMPLYMSDPERTAAIAGAAVDLALELKERS
What is the function of this protein?
Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
What are the official names of this protein?
Phosphoenolpyruvate transferase, EPPG:FO PEP transferase.
What is the protein family that this protein belongs to?
Belongs to the CofD family.
Protein: PIMT_YERPP
Sequence: MVNKRMQTLLMQLRQQGIHDERLLQAIEAVPRERFVDEALAHKAYENTALPIGAGQTISQPYMVARMTELLQLTPTSRVLEIGTGSGYQTAILAHLVDHVCSVERIKGLQWQAKRRLKQLDLHNVSTRHGDGWLGWQSRGPFDAIIVTAAPPEIPDALLEQLDEGGILVLPVGEQFQTLKYVQRRNNEYHIETVEAVRFVPLVKGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PITX_BRABE
Sequence: MDTLNDSLSLEQLVSVSPRRSQLTMAGIPPINNSGTSTGSALDSTAVSGAHTSLAGTDSSMDSTHGSGAATVSAGSPVGKDSGSGSTPSTDVTQDDDEMRKRRRQRRQRTHFTSQQLQELEASFARNRYPDMATREEIAAWTNLTEARVRVWFKNRRAKWRKRERNQLGEFKNGFGPHFNGLMQPFDDGLYSGYSPAYNNWAAKVPSPLTAKSFPWGLNSSGVPNVNPLSSQAMCFTPPTTIGTATTMVPSMNVGNGLNSLSSLQNPTVAPCPYASPGQPYAYREQCNSSIAALRLKAKQHSTSVASSFSYPSPVRQQTLSACQYAVDRPV
What is the function of this protein?
Involved in left-right asymmetry in the developing embryo.
What are the official names of this protein?
Pituitary homeobox x, Bicoid type transcription factor Pitx, BbPtx, Homeobox protein Ptx, Paired-like homeodomain transcription factor x.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLSB_ALIFM
Sequence: MSTGHTIYHSLLKLPLSVMVKSSSIPSNPIEDLNIDLERPIIYALPFRSHVDLLTLQKSALELGLPDPLSPIEIEGVKYPRYVFTSIGPKMFDTDDDLPQESLDLFKIVLKHHADNPDADFQLIPTSILWGRKPGKEGTSKPHLMPLNGPQKFVTLIKAGRDSTVRISPVVSLRYMADNHGSDEAIAHKLARVAKIHFSRQKLAASGPNLPNRQALFNRLLKSQAIEKVILEEAKSRNVDVEKVRKEAMGIMEEIATNFSYSLIKNGNRILKWLWNRLYQGLNINNASTVRKLAQEGHEIVYVPCHRSHMDYLLLSYVLYHEGLVPPHIAAGINLNFFPAGPIFRRGGAFFIRRSFKGNRLYSTIFREYLAELFAKGYSVEYFSEGGRSRTGRLLQAKTGMLAMTVQAMLRGLNRPVTLVPVYIGYEHVMEVTTYAKELRGKRKEKENAGQVLRTLRKLRNFGQGYVNFGEPISLNHYLNEHAPNWSESINPIEPQKPEWMTPVVNGIANKMMTHINDAAAANALTLCATALLAANQRALSKEDLTEQLDCYLQILRNVPYSATATVPSEDADALLEHAIKLDKFVIEKDTLGEIVSLDRNQSLLMTYYRNNIIHLFALPSLIAKLVVHHDTITVEQIQEQIKLIYPFLKAELFLHYEEDELASIVNNHIDELVQQNLILRDGDTLQLCNANIRKLHLLAHTISETLQRYAIALTHLQASPDLGKDELEEQSQIMAQRLSRLHGINAPEFFDKGVFCILFNTLKTEGYLDEDGAAVLSKVEPLSQDIAHLLTPEIKLTIHAVMTKED
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ISPD_HAEDU
Sequence: MNRKIIAIIPASGIGSRMNAALPKQYLTLQGKTILEHTVAIFLNHPQIDKIVIALSANDQHHQHISLLTSDKIQLVNGGASRAESVFNALQSIDEHSWALVHDAARPCLKRSDLDKLLQITDQNGAILASPVVDTLKRAEGNKISHTEDRTTLWHALTPQFFPTALLKQALQQAFDRQQNVTDEASAMELAGYQPTLITGSNSNLKITRPEDLALAEFYLMHSLEK
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: FM25A_HUMAN
Sequence: MLGGLGKLAAEGLAHRTEKATEGAIHAVEEVVKEVVGHAKETGEKAIAEAIKKAQESGDKKMKEITETVTNTVTNAITHAAESLDKLGQ
What are the official names of this protein?
Protein FAM25A.
What is the protein family that this protein belongs to?
Belongs to the FAM25 family.
Protein: URED_STAAC
Sequence: MDEQQWTGQLDLTVFFDGNRSVSRDIFFEKALKVIRPVYLNQSTIPTFYIVNVGGGYLDGDRYRMNVNVEDNAKVTLTSQGATKIYKTPSNHVEQYQTFNLKDNAYLEYVADPIIAYENAKFYQHNTFNLNNSSSLFYTDILTPGYSKTGEAFKYQYMHLINEIYIEDELVTYDNLLLNPNKQSINEIGYMEHYSHYGSAYFIHEDVNQKLIDSVYETISSYSNTFDCRVAISQLPTHGFAVRIFAYRTQIIEKILGTIQSYIAENIYDRKLDFLRKY
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_ANADE
Sequence: MADELGTTEREIIAQRLKKAEALRALGVNPFGNGWQPRHLAEELLRHHGDQPAEEIAKAPGDWSLAGRVLAVRSFGKAAFLRVRDRSAELQVWVKKDRVGDQAFEVFKLLDIGDIVGAEGPATRTKTGELTLEARTFTILTKATRPLPEKWHGLTDVEQRYRQRYVDLVVTPGVREAFVKRARIVSGIRRFLDARGYLEVETPTLHKPEEAGGAAARPFETHHNALDLDLKLRIATELHLKRLVVGGLDRVYEIGRIWRNEGIDRRHNPEFTSIEFYQAYATHEDLMRLTEELMHQLAVEVTGGPVVTFQGQAIDLTPPYPRVSMLEVGARALGLAPDDALAGRGLAEALSRAAARENDSEDAWKLEQAAKKTPGEAVALAFEIFGEPQLPKDRPAFVVDFPLETSPLSRRRDADPRLVDRFELFAAGMELANAFSELNDPADQRARFEAQMRAKAAGDEEAMPYDEDFVRALEHGMPPTAGEGIGIDRLAMLFTDSASIRDVILFPLLKSRD
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_STRPS
Sequence: MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKYMKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLPELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSEAIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLDRLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERVKYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENHTSLRELGKY
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: LEXA_CAUSK
Sequence: MLTRKQHELLMFIHERIKESGVSPSFDEMKEALDLASKSGIHRLITALEERGFIRRLAHRARALEVVKLPQQATTAAPPKGRGAFRPQVLEGGGQAPTTSAQPQMAADNSRELPILGRIAAGTPIDAIQHERERLPVPESMLGAGEHYVLEVQGDSMIEAGILDGDYVIIKKGDTANSGEIVVALVGEEATLKRLRKKGGSIALEAANPKYETRIFGPDQVEVQGKLVGLIRRYH
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: COAE_BACSU
Sequence: MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGMPAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDEAVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIRSQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNU1_SHIFL
Sequence: MAITKQDIWRAADELDAEGIRPTLAAVRKKLGSGSFTTISDAMAEWKNRKTATLPSSDPLPVAVNEHLAELGNALWAIALAHANARFDEDRKQIEADKAAISQQLAEAIELADTFTRENDQLRERVNQLEPMERERDKLADQLAEVKRRSGEELNRCMEKLTQRDNEAIEARKQAKEAIERAASLQGQVEALKEQVANLTAVLKTGGKQ
What is the function of this protein?
May influence the expression of the nuc gene.
What are the official names of this protein?
Uncharacterized 23.2 kDa protein in nuc 5'region.
Protein: VE2_HPV39
Sequence: MKETMMKTLSQRLNVLQDKILEYYEQDSKSIYDQINYWKCVRMENAIFYAARERGMHTIDHQVVPTINISKCKAYQAIELQMALESVAQTEYNTEEWTLKDTSNELWHTQPKQCFKKQGTTVEVWYDGDKCNAMNYVLWGAIYYKNNIDIWCKTEGCVDYWGIYYMNEHLKVYYEVFIQDAERYGTSGKWEVHYNGNIIHCPDSMCSTSDGSVPTTELTTELSNTTATHSTATTPCTQKTIPPPSRKRPRQCAVTEPTEPDGVSLDHLNNPLHSNSTGHNTRRYLSCGNTTPIIHLKGDKNGLKCLRYRLQKYDTLFENISCTWHWIRGKGTKNAGILTVTYATESQRQKFLDTVKIPSSVHVSLGYMTL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RPOL_BPK11
Sequence: MNALNIGRNDFSEIELAAIPYNILSEHYGDQAAREQLALEHEAYELGRQRFLKMLERQVKAGEFADNAAAKPLVLTLHPQLTKRIDDWKEEQANARGKKPRAYYPIKHGVASELAVSMGAEVLKEKRGVSSEAIALLTIKVVLGNAHRPLKGHNPAVSSQLGKALEDEARFGRIREQEAAYFKKNVADQLDKRVGHVYKKAFMQVVEADMISKGMLGGDNWASWKTDEQMHVGTKLLELLIEGTGLVEMTKNKMADGSDDVTSMQMVQLAPAFVELLSKRAGALAGISPMHQPCVVPPKPWVETVGGGYWSVGRRPLALVRTHSKKALRRYADVHMPEVYKAVNLAQNTPWKVNKKVLAVVNEIVNWKHCPVGDVPAIEREELPPRPDDIDTNEVARKAWRKEAAAVYRKDKARQSRRCRCEFMVAQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDMTKGSLTLAKGKPIGLDGFYWLKIHGANCAGVDKVPFPERIKFIEENEGNILASAADPLNNTWWTQQDSPFCFLAFCFEYAGVKHHGLNYNCSLPLAFDGSCSGIQHFSAMLRDSIGGRAVNLLPSDTVQDIYKIVADKVNEVLHQHAVNGSQTVVEQIADKETGEFHEKVTLGESVLAAQWLQYGVTRKVTKRSVMTLAYGSKESLVRQQVLEDTIQPAIDNGEGLMFTHPNQAAGYMAKLIWDAVTVTVVAAVEAMNWLKSAAKLLAAEVKDKKTKEVLRKRCAIHWVTPDGFPVWQEYRKQNQARLKLVFLGQANVKMTYNTGKDSEIDAHKQESGIAPNFVHSQDGSHLRMTVVHANEVYGIDSFALIHDSSGTIPADAGNLFKAVRETMVKTYEDNDVIADFYDQFADQLHESQLDKMPAVPAKGDLNLRDILESDFAFA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the phage and mitochondrial RNA polymerase family.
Protein: DPOL_HBVA2
Sequence: MPLSYQHFRKLLLLDDGTEAGPLEEELPRLADADLNRRVAEDLNLGNLNVSIPWTHKVGNFTGLYSSTVPIFNPEWQTPSFPKIHLQEDIINRCQQFVGPLTVNEKRRLKLIMPARFYPTHTKYLPLDKGIKPYYPDQVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELQHSQRHGDESFCSQPSGIPSRSSVGPCIRSQLNKSRLGLQPHQGPLASSQPGRSGSIRARAHPSTRRYFGVEPSGSGHIDHSVNNSSSCLHQSAVRKAAYSHLSTSKRQSSSGHAVEFHCLAPSSAGSQSQGSVSSCWWLQFRNSKPCSEYCLSHLVNLREDWGPCDDHGEHHIRIPRTPARVTGGVFLVDKNPHNTAESRLVVDFSQFSRGITRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLLIGSSGLSRYVARLSSNSRINNNQYGTMQNLHDSCSRQLFVSLMLLYKTYGWKLHLYSHPIVLGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHRESLYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGYIIGSWGTLPQDHIVQKIKHCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQYMNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCTANWILRGTSFVYVPSALNPADDPSRGRLGLSRPLLRLPFQPTTGRTSLYAVSPSVPSHLPVRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: C3H47_ORYSJ
Sequence: MADPNGRRRLPTGDPDQANASPSRRVSAVDGVTGGEGRPTYSHFPPGAYEPTDVAYGIRDAANDERARARARARHDQGGGAHDHHHDRPRQDQRGEAHLHDLPGEKSEVPDVGPSDQQGKEASDTDMAPLAALAKRSYDVNFPPLHEHRAAPFPAPAPAFAPAPAGTMGSSSAQVQGDGAPDNHDHDPRHLPRQDQSGGAHPDDLHGEKTIGSGSDILDDSKRGMINAGPQHGRITTSNGGSGSGSDKGKGVSYAGDKPASSSSSSSSAGQQGSDTDKTPSAAAASSYAVNFPPLLPAPAPVPAPAPAPAVAGAMGVANAHHKIALCSKWRKGRCHNGAACRYSHGEEEQRIVPEMRVGGGGRPCPELAAAKGWCRYGLNCKYCHGGV
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 47, OsC3H47.
Protein: TORS_DROME
Sequence: MMSFPRMLSLCLSVLVILPLPLQSVDPLTIGAVGAVALGAYFKEHTYCRFAECCDDRNIPARIDELERSLERTLIGQHIVRQHIVPALKAHIASGNKSRKPLVISFHGQPGTGKNFVAEQIADAMYLKGSRSNYVTKYLGQADFPKESEVSNYRVKINNAVRDTLRSCPRSLFIFDEVDKMPSGVFDQLTSLVDYNAFVDGTDNTKAIFIFLSNTAGSHIASHLGSVMKNGRLREDTRLSDFEPLLRKAAYNMDGGMKKTTMIESHVIDHFIPFLPMEKAHVIKCLEAELLRWRRDPKQANNQKIIEDIINSSISYDRTHSLFAISGCKTLEKKVAMAIY
What is the function of this protein?
May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
What are the official names of this protein?
Torsin-like protein.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. Torsin subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RL24_BACCN
Sequence: MHVKKGDKVQVITGKDKGKQGVILVAFPKENRVIVEGVNIVKKHSKPSQLNPQGGIITKEAPIHVSNVMPLDPKTGEPTRVGYKVEDGKKVRIAKKSGELLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: LIN25_CAEBR
Sequence: MHIAVDNLTISVPKIDKPTKAALDYVELLRESFSAKKRQKFSKASLAIRPSDFPDLSNQQLCDILVRVAYNGSHIDEDFRKHVLDLVEDQSLTWNQVLLSVIRTQSDQLYMKSQLCELITEMIRFVQIKSFHDPKHADSLISVILPTFVFLTKLILELLSDEDEMETIQIEYETKFPPYHKPLQALNTLIHDNLCGPLLAMYRSSEEVTRQLVLCSEAFSKLERPDESSVGLLDLILEKHQDNCKPTKYEYTPDGLAAYDLKNPSVRILVPIFACFRCHETSKQMAETVQIFVDIMRVSGDDVVFDLLHAAILLKCEESNNLLHLSKQHRLDFRWQSTTFFYKKLPQIIEHLVSFGKVTAEDVQKGMERALNDLTMLFDVADISWQNASFLTVLNALEPLIGSEAANPLRHRRREYMRKTASLTALADSDEKLIENTDIDRLLNAVKQVMNLQFGQNEEFYQEFIRKVNGDDCEDFDAVMSILISEGRLLEVGKAFAMKSKLAQYPSELSLDERIKKFDETFLLLTRIIVKFPGLSIGLLVNGGPGEISIADSIFYRWSMWYVKRVPRKDKSEEKSEEELEAMRIQAKVLIEEINKEVGIEEEIEEEEEDIEPEVVKEMKESGTEKEKEEEEEDGNKETKNETANDEEMPGDEQKTEEKMDTSETPAEPPIQQQSTPEDPPKVEEPAERINQEKPEEKPKEPLEPTWNEMNCALPRISRKKARRYLGLLKQGNPFWSTDNNSLNIGAILAALPSMGKLLIEEHNEEKHRVDRKSAEEHMANIIHALESMPCLFVCLVQWVDCAPASPARTLLAKTMKNALEKRVSSSSASIADDTNLPKWRFILSTCNEMIHELTDRVPVFPDITCTAFSAARRLCPFVTRDEIPDSTKLKHAWYYMCQQSWTSPHALRLLEHANIHSEYNTWIHLYITKIVGGGCGEIMKDQVDMIFGMLMMDDLNVIIRMHEIMMDFWLSEEAGNLQLDGRFDPLSMTAVIRLMANVMLISEWTLDRLINDGPPLVEFDFTSAMTPEPEDPLRREKWVFLLRQMLDRTVNRLFKILRQGVLCTVVNTIVRLIKAIAGSADCKAKRLLIKRIPPEIVFQLAYIEPQCADYALMNAYCDPKNEEHTRTKIRFLCALRRSHIL
What is the function of this protein?
Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types.  Positively regulates the fate of vulval precursor cells.  Required for induction of the P12 and excretory duct cell fates.  In males, it is also required for proper formation of spicules.  Does not function in the signaling pathway that promotes exit from pachytene (By similarity).
What are the official names of this protein?
Protein lin-25, Abnormal cell lineage protein 25.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.