PharMolix/UniProtQA huggingface dataset:
Protein: NDUAB_RAT
Sequence: MAKRFFEAYNETPDGTQCHRKAYITTALGGLCGLISSAYSITHNPADSPLEAVARVGRFTFTAAAIGAMFGLTTCVSAQVREKPDDPLNYFIGGCAGGLTLGARTHSYGTAAIGCVYMGTAAALFKMGKLEGWELFATPKV
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11, Complex I-B14.7, CI-B14.7, NADH-ubiquinone oxidoreductase subunit B14.7.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA11 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
Protein: SP2AB_GEOSE
Sequence: MRNEMHLQFSARSENESFARVTVAAFVAQLDPTTDELTEIKTVVSEAVTNAIIHGYNNDPNGIVSISVIIEDGVVHLTVRDEGVGIPDIEEARQPLFTTKPELERSGMGFTIMENFMDEVIVESEVNKGTTVYLKKAYCEKQTLCN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: RLMN_THEP3
Sequence: MYNLKDMTLEEMEEFFVNIGESRYRAKQIYKWIYGKKVTDFDQMTDISKNLRSKLKEIAYVSQLKIEERRVSEIDDTVKYLFLLEDGNIIEGVAIKYRFGNTACVSTQVGCNMRCSFCASAIGGKVRDLKASEMVDQVMAIDSDYGKISNIVLMGSGEPFDNYDEVMKFIKIVNNPHGLGIGSRHITISTCGIVPKIYQFADEKLQVNLSISLHAPNDELRTQLMPINKAYPLEELMKACKYYVDKTRRRITFEYSLIEGVNDKKEHAYQLVDLLKGMLCHINLIPINYVREIGFKKANNEKVMMFKRIIEDAGISCTVRRELGSDIEAACGQLRRKYLKER
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPR_BACVZ
Sequence: MKNNELDVNQFLIRTDLAVETKQAVKDGQAGQKKEINGFIEKERDKGGIKVRTVDITKEGAELSGKKQGRYVTIEAQGVREHDSDMQEKVTEVFAEEFSAYLSALKIPKDASCLIVGLGNWNVTPDALGPLVTENLLVTRHLFRLQPENVQEGYRPVSALAPGVMGLTGIETSDIIQGVIKESKPDFVIAVDALAARAVERVNTTIQFSDTGIHPGSGVGNKRKELSKETLGIPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDDSPSRSLVPAGMNFGKKKVLTDEDLPGEKERQSFLGIVGTLDENEKRQLIHEVLSPLGHNLMVTPKEIDTFIDDMANVLANGLNTALHEKVSQDNKGSYNH
What is the function of this protein?
Initiates the rapid degradation of small, acid-soluble proteins during spore germination.
What are the official names of this protein?
Germination protease, GPR endopeptidase, Germination proteinase, Spore protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase A25 family.
Protein: DP2L_METVS
Sequence: MLHVSASKNMTEYFKSILNDVNNLYFIAEECRKLGYDVVDKVEIPLAKDMADRVEGIVGPPKVSERIRELVMELGKEPAALEIAKEIVEGRFGEFGKEEGAEQAVRTALAVITEGIVAAPLEGIAHVKIKKNHDGTEYLAIYFAGPIRSAGGTAQALAVLVGDYVRKNMNLDKFKPTDDEVERYGEEIDLYQSEVTTFQYQPKIEEIRTAVRNISVEITGEATDDVEVSGHRDLERVETNQIRGGALLALVEGVLLKAPKILRHVDKLEIEGWNWLKELKNKKEEINEDIKDEKEDFNYEEEEDLSQYDDCEIEEVTKFIGEVIAGRPVFAHPSKKGGFRLRYGRSRNTGFATDGFHPAIMYLVDDFMAVGTQLKTERPGKATCVVPVDSIDPPIVKLNNHSVLKIDTVEKAIKYRKDVLEILFLGDILVNYGDFLENNHVMLPSSWCVEWYEKILKVNNIPYSTEFISNPSPKEAVKFAITTKTPLHPVYTYHWHDISKENIYSLRNWILRGNFNKNSDKWEISYDLENPEDISNKRFLELIGCCHEVVDGKIFILEYYPLLYSLGYDYENSFDSVENLEEKVSNAKNNMHLINLLSHFEIRRNTYIYVGARMGRPEKAASRKMKPPVNGLFPIGNAGALVRLINKAVEGGKTDEIEISNVMCSCGKVSLYKKCPFCGKSVIPTGPTRIKLPIKDYWYNALENLKINKPGDVKCIKGMTSKDKIIEPLEKAILRAVNDVYVFKDGTTRFDCTDVPVTHFKPCEINVSVNRLKELGYLRDINGNSLENDKQVLELKVQDVIVPESCMDYFLNVSKFIDDLLEKYYKKNRYYNSSNKEDLVGHLIIGMAPHTSAGMVGRIVGYSKANVGYAHPYFHASKRRNCDGDEDAFFLLLDAFLNFSKKFLPDKRGGQMDAPLVLTTILDPKEVDGEVHNMDSMWEYPLEFYEKSLEMVTPKEIKKLMETVEDRLGKDEQYEGIGYTHETLKIDEGPLICSYKTLGSMMDKTSAQLAVAKKIRATDERDVAEKVIQSHFVPDLIGNLRAFSRQGVRCKCGAKYRRIPLKGVCRKCGSRLILTVSKGAVEKYMNVSQTMAEKYNVSDYIKQRLEIIRSGIDSLFTNDKRKQVKIEDFFK
What is the function of this protein?
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.  Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase II large subunit, Pol II, Exodeoxyribonuclease large subunit.
What is the protein family that this protein belongs to?
Belongs to the archaeal DNA polymerase II family.
Protein: FADB_PHOPR
Sequence: MIYQGETLSVRYLDDGIAELNLNAPGAVNKFDLKTLECLNEALNALYQQSDLKGLLITSDKDAFIVGADITEFLGLFAKPAEELSQWLTRANDIFNKLEDLPVPTLSAINGHALGGGCECVLATDFRLADITARIGLPETRLGIMPGFGGTVRLPRLLGADSAMEIITAGKDKKAQDALKLGLVDAVVAPTALKDAALSMIKDAIAGKLDWQKRRAQKKAPLTLNKIEATMSFTMAKAMVAQVAGKHYPAPMTAVIAIEAAARMSRDEALVVENKHFITLAKTDVAQSLVGIFLNDQYIKGKAKKAAKEGQPTKKGVVLGAGIMGGGIAYQSALKGVPVLMKDIAVPSLDLGMAEAAKLLNKQLERGRIDGVKMAKVLSGITPSLHYAGAEDADIVVEAVVENPKIKAAVLAEVESNVSDTTVIASNTSTIPINLLAQSLKRPENFCGMHFFNPVHRMPLVEIIRGEHTSEETISRVVAYAAKMGKSPIVVNDCPGFFVNRVLFPYFAGFSLLLRDGADFTQVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAEGFPDRMGKNYKDAVDVMFEQQRFGQKNGNGFFAYSVDRRGKPKKNVDPAVAELLAPVLGAATDFTSDEIIARMMIPMINEVVRCLEECIIATPAEADMALVYGLGFPPFRGGVFRYIDTLGLAEYVAMADKFAHLGAVYEVPTGLREKAAKGESYYTQQVNA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: AK17B_MOUSE
Sequence: MTVTVVYDNSEATELCAAQHLYLKPIAKLMINVLLPECIEPVRPFSNWEVLDQLKSLICPDQFTTVRLSKSTKDFIRFEGEAETRSLVQILKAKLHGKIIKLNGLKTDLKVVATDAQGEWEHFPKEKEASVIEGAEEQDHDKGPDSIYFEGLPCKWFAPKGSSGEKPCEEILRVVFESFGKIKNVDIPMLDPYREVMTGGSFGGLNFGLQTFEAFIQYQESTDFIKAMESLRGMKLMLKGDDGKALACNIKVMFDTTKHFSEGAIQRRNQERLKLQELEEERKKEKKREEEVAERKRKDEVRKAQEKRKKARDRRRALKERDRHRQRKEKVKTKPEARQELDSSGEWEERKYLLARRRVEALRLLRVLLKKIAVWMRKEKNLKPCQTHISLLLNCLGSTQCNPQEVGVMKSEAHHTPGTALKSPEEEELNTRHLLDWEEMPSYQASTLDLSQKAEKRCYQASKSDNKQKQKGKKKTKAQLQKSSHTPGVKQMRHSARKEETGKVLSDGCDYSLVSDQNSLQSTMIADQSLAKEDHASSNESHSSRQAVINRGRKQKIYETDEFIDYLLNYYQTPEYARFCLEASHLTSTCQWQRDVYAKGDGFQIYLRKQGYHSNSLSEEESLQGIEQDEEQDWPQVYIKDPESKSQKTGKINYAKEFTKKLKNHCKDIASETDEHLSPTDGESYPVEKIHSHGVKDSQHIRKSPVSSSLRSVDVGLPLADFLEEISSDSECFSETLSMNQEEEERSMAVYNSSPEKRPLGTDKISTCKQKTKSSQQTLCSEWKHDNEGKYSKHRVRAPGKRSKSELRYSWLEEEGDSIRVDKNISKTRGKLAPKHMLDEGQYHESSSSDELESTTRKKRRLTSGMFDQNVKYRPLHMPSMPPKRARAFYLGYFSRKRQTPWKSEYNQDVRRFKRYENSEDYTLDSDNYYVSHDDNQEHIEYGSYLGDSYSSSLYFKMF
What is the function of this protein?
Splice factor regulating alternative splice site selection for certain mRNA precursors.
What are the official names of this protein?
A-kinase anchor protein 17B, AKAP-17B, Protein Talia, Protein kinase A-anchoring protein 17B, PRKA17B, Splicing factor, arginine/serine-rich 17B.
What are the subcellular locations of this protein?
Nucleus speckle.
Protein: Y5317_BACCR
Sequence: MTEIVKVREQLQMSLSDFQEQASLQSGQIFVVGCSTSEVLGERIGTSGTMEVAEAIFSELKQFQEQTGIELAFQCCEHLNRALVVEREVAIKYQFEIVTVTPVRSAGGALGTYAYHNLKDPVVVEFIKADAGMDIGDTFIGMHLKHVAVPVRTNVKEIGSAHVTMAKTRGKLIGGARAVYAAVEETTTCR
What are the official names of this protein?
UPF0340 protein BC_5317.
What is the protein family that this protein belongs to?
Belongs to the UPF0340 family.
Protein: RLMF_SALAR
Sequence: MSAQKPGLHPRNRHQHRYDLAALCQTTPELTSFLTRTPAGEQSVDFANPQAVKALNKALLAHFYAVTHWDIPQGFLCPPVPGRADYIHHLADLLGETTGSIPVQANILDVGVGANCIYPLIGAYEYGWRFTGSEISEAAMSSAQAIIQANTGLSRAIRLRRQKDSTAIFTGIIHKNEYYDATLCNPPFHDSAAAARAGSERKRRNLGQKRDDVLNFGGQQQELCCEGGEVTFIKKMIAESQTFRRQVLWFTTLVSRGENLPPLYRALTEVGAVKVVKKEMAQGQKQSRFIAWTFMDDDQRRRFITRKR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4LM_CALLC
Sequence: MTQASTNILLAFFFSLLGTLIFRSHLMSTLLCLEGMMLTLFIMSTMTALNSQSTVMYTIPIVMLVFAACEAAIGLALLAMISNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COAE_MYCPN
Sequence: MLIAVVGKAGVGKTTVLQYIADYFHFPVFFADRFIHQQYANGQAGYAIVKQQFGAQFVNHEAVDRKQLAQYVFNQPDELKRLSNLTKPLVQEWLNQLKAQFQDKIALVEIAVMLNYWNDYRPFFDEVIQIERDAKIVKQALKARGVDVEQVQKLIADPTYPILTVINNSTVAECALHVTQFLESIAKSDKCHHGHYQTPK
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNA1_MOUSE
Sequence: MKPDETPMFDPSLLKEVDWSQNTAIFSPAISPTHPGEGLVLRPLCTADLNKGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFDYTVSEENYMCRRFLK
What are the official names of this protein?
Glucosamine 6-phosphate N-acetyltransferase, Phosphoglucosamine acetylase, Phosphoglucosamine transacetylase, Protein EMeg32.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. GNA1 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Protein: U6E_CONCL
Sequence: TVKRSSKRGWWGPPSNCWVCTGFNKCCEHESHCMTFPTQYNRECK
What are the official names of this protein?
Conotoxin Cl6.14.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBX_GUITH
Sequence: MTPSLSAFINSLLLGLFIVVLPIGTALLLVSQSDRVTRN
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TM196_HUMAN
Sequence: MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHKPQLGDSSPVWSGVCFLLCGICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKKTSSLYPLHLASMSLACIGIGGCTLSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEITDNMSNGGPQLIFNGRV
What are the official names of this protein?
Transmembrane protein 196.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y727_HELAH
Sequence: MRFFNNKHKEKGLKAEEEACEFLKTLGFEIIERNFFSKFGEIDIIAFKKGVLHFIEVKSGENFDPIYAITPSKLQKIIQTIRYYLSQKDPNSDFCIDALIVKNGKFELLENITF
What are the official names of this protein?
UPF0102 protein Hac_0727.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: HSLO_STRZT
Sequence: MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGRTLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATGEVLVGPFVGNGQFLVITDYGTGNPYNSITPLISGEIGEDLAFYLTESQQTPSAVGLNVLLDEEDKVKVAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIYGDEAYKRLSEEEIRFQCDCSHERFMNALASLPSSDLQEMKEEDHGAEITCQFCQTTYNFDEKDLEELIRDKS
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAK5_PICST
Sequence: MAPNNKKIKGKSNVGKGSKSKKGQQTRKTPTLKQKLHRESKVVKAESLNWKTVEVPDNLDDWEGFYGLEEIDGVDVKIVNGKAEFIVKDNKKVKKGKTEEQEELEDDEEQDEDEESEADEEQGEDEDEDEEHEEDKINEENEDEFEEEEFTGFDDDSEIQDGMEVEDILDEDINEIGEVDESVEPVQESKPEHDEELSENVFQHSQFVLPDDEDINLPHWQNEDSNFSLSPYTLHGLSVLGFDKPTPIQKKTIPLAAEGKDVVGKAITGSGKTLAYGIPILEKYLSNLSIINQNRQKKIINHPTGIIFAPTRELAHQVVSHLNSLAKYSPLSTNGIVSITGGLSIQKQERLLSHGPGIIVATPGRILELLQKDEDLTKRLASTDIIVLDEADRLLQDGHFEEFETILDLFRKNRPKNKTFPWKWQTLVFSATFSRDLFGKLDKNQKSHKRNSEGSSLIGNDEILNLLNDKLKFKDTRPALVDANPKEIVSGNITEALVECGPTERDLYLYYFLLMYKGSTLVFANSIDSVKRLVPFLNNLNIPAFAIHSSMIQKQRLRALERFQKASEKNDTAVLIASDVAARGLDIPNIDHVAHYHLPRSADVYIHRSGRTARAGKEGVSVMFCSPQEASGPLRKLRRLVANNSTKGGRLNMHNDVKLLPIEMDLVSQLKPRVIIASKLADADISNTSTRKEDSWVKQAAEELGVDDLSDLDDFEDDIIKKQRKRKEGKMITKDEKKGLRYELKELLSKSIRKETRRSYLTSGLQNIAHQMVTGVGHEDVVGHSKVNALDDLKGKKVARSKAGKVTKPSQKKQEKKQKKQERKDTMRKQKEGNRK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase MAK5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DEOC_MYCLE
Sequence: MQGQPTRKQLAALVDHTLLKSEATHADVAALVAEAVELGVYAVCVSPSMVPAAVEAGAGGLRVATVVGFPSGEHVSIVKAQEAVQAVASGATEIDMVIAVGAALAGDLDAVRSDIEMVRSAIAGVVLKVIVESAVLLGQANERTLAEVCHVAEAAGADFVKTSTGFHPAGGASVRAVTLMTEAVGGRLGVKASGGIRTAVDAIALLDAGATRLGLSSTREVLDGLS
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR7_CITSI
Sequence: MSRRGTTEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRALKKIQQKTEKNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPIEIGSAQGKALAVRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MCES_HUMAN
Sequence: MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLSEKTSVCRQVDIARKRKEFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRETEDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVGLEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATSIYLVFAFEKQQ
What is the function of this protein?
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871).  Binds RNA containing 5'-terminal GpppC (PubMed:11114884).
What are the official names of this protein?
mRNA cap guanine-N7 methyltransferase, RG7MT1, mRNA (guanine-N(7))-methyltransferase, mRNA cap methyltransferase, hCMT1, hMet, hcm1p.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMC_PSEAE
Sequence: MDPRSEVLLRQRHLFATPLLLAGLPADDLLAELPQAQGWSWHAGEQAQLDARFPGRSRFDTRAPTGAWTSAVLFLPKSRELTDYLLASLAARLPGGELFLVGEKRGGIERASKQLAAYGKPRKLDSARHCQLWQVRIEQAPAEPDLHALAQRYSLPLADGELQVVSLPGVFSHGRLDRGSALLLGQLQALPGGHLLDFGCGAGVLGAVLKRRYPASRLSLLDVDAFAVESSRLTLAANGLDGEVIAADGIDGAPRELAAIVSNPPFHQGVHTDYQASERLLQRAAEHLAPGGELRLVANSFLKYPPLIERHLGPCRTLAEGDGFRIYSARRS
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMN1_KLULA
Sequence: MSCVSSISSKRSRCEGFDDDFIHTPLKKCSKGYHEWSLSITTPATTPTGKLDYKRKTKSLDDDLISSPVKFGTDANVLNAEFQELSLQKLLVSLSTSDDSKSNPIFHIPELLHRIFNFLDHESLYRCSKVNPVWAAVASSIINKDLVIQQSSISGDLKIVELDQKVHPKSLTFYKLKQHRNFIENQLPRIRFTRLNSLNFYISPVLPAIFDDVTISNNLTKLTIAGNKKINDEELISLILGLPNLIDLDLRACSQISDISIVSIVTHCPKLQSINLGRHENSHLITDLSIMALSELEHLTTVGFSGCDKISDVSIWQLYSKHSTTLVRLSINGCTQISDSSISDIVAKHGFPNLKVLDIRNCQLVRFKNLIQYRDWRHKYLMKPIHIHISDSMKKEFELQEQQLYKEFRTRIVNDLNRWVNEAT
What is the function of this protein?
Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints.  Required for daughter cell separation and chromosome stability.  Involved in copper sensitivity.
What are the official names of this protein?
Antagonist of mitotic exit network protein 1.
What is the protein family that this protein belongs to?
Belongs to the AMN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FTHS_PARDP
Sequence: MKSDIQIAREAQKLPIAQIAGRLGLAEADFLPYGHDKAKIAHEAIAALAGRPQGRLILVTAINPTPAGEGKTTTTVGLGDALNRIGKRATVCIREASLGPNFGMKGGAAGGGHAQIVPMEDMNLHFTGDFHAVTSAHNLLAAMIDNHIHWGNALRIDPRRVTWRRVMDMNDRVLRQVVVALGGPANGVPRECGFDITVASEVMAILCLASDLADLQARLGRIVIGQTFDRRPVTAHDLGAEGAMTVLLRDALQPNLVQTLENNPALVHGGPFANIAHGCNSVMATRTALALSDYVVTEAGFGADLGAEKFLNIKCRLAGLQPAAAVLVATVRALKMNGGVARTDLGAENVAALRAGCANLGRHIQNLRRFGLPVVVAINHFSGDTEAEIAALADYCRERGVQAVLCRHWAEGGKGAEDLARAVVALAEGGADFTPLYPDEMPLAEKIETICHRIYGAGQVEFLPHIVERLEEWQAAGHGHLPVCMAKTQYSFSANPAALGAPEGFTIPVREVRLAAGAGFVVAICGDIMTMPGLPREPSALRIGVDADGHVQGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: O17A_CONCF
Sequence: TCKQKGEGCSLDVECCSSSCKPGGPLFDFDC
What is the function of this protein?
Gamma-conotoxins may act on voltage-gated non-specific cation pacemaker channels (HCN) (By similarity).  Elicits toxic effects in the freshwater snail Pomacea paludosa after intramuscular injection, but it has no effect when injected intracerebrally into mice.
What are the official names of this protein?
Gamma-conotoxin-like As7a.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KLH22_HUMAN
Sequence: MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRSQADPDFASEVMSVSDWEEFDNSSED
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores.  The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.  Monoubiquitination of PLK1 does not lead to PLK1 degradation (PubMed:19995937, PubMed:23455478).  The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5.  Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway.  It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719).
What are the official names of this protein?
Kelch-like protein 22.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Lysosome. Note=Mainly cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase (PubMed:23455478). Localizes to the nucleus upon amino acid starvation (PubMed:29769719). Relocalizes to the cytosol and associates with lysosomes when amino acids are available (PubMed:29769719).
Protein: RL6_BRUAB
Sequence: MSRIGKKPVPVPAGVTGSVEGQTVKAKGAKGELSFVVHDEVLVKMEDGAVRVDPRDQSKEARSKWGMSRTMISNIFVGVKDGFEKKLEISGVGYRAAMQGKNLQLSLGFSHEVVYDVPAGITVAVPKPTEIVVTGIDKQQVGQVAAEIREYRGPEPYKGKGVKYAGEKIVRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NU4LC_LEMMI
Sequence: MMFEHVLFLSAYLFSIGIYGLITSRSMVRALMCLELILNSVNINLVTFSDLFDSRQLKGDIFSIFVIAIAAAEAAIGLAIVSSIYRNRKSIRINQSNLLNK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic, NAD(P)H dehydrogenase subunit 4L, NADH-plastoquinone oxidoreductase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.