PharMolix/UniProtQA huggingface dataset:
Protein: ODO1_BOVIN
Sequence: MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFGQIRCYTAPVAAEPFLSGTSSNYVEEMYYAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSPGSLSAVARAGPLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGVMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPRSMTCPSTGLTEDILTHIGNVASSVPVEDFTIHGGLSRILKTRGELVKNRTVDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSNFDEMLPGTHFQRVIPEDGPAAQNPGNVKRLLFCTGKVYYDLTRERKARDMVEQVAITRIEQLSPFPFDLLLQEVQKYPSAELAWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDAFKNFS
What is the function of this protein?
2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC).  Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC.  Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST).  Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids.  Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate.  Mainly active in the mitochondrion.  A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
What are the official names of this protein?
2-oxoglutarate dehydrogenase complex component E1, E1o, OGDC-E1, OGDH-E1, 2-oxoglutarate dehydrogenase, mitochondrial, Alpha-ketoglutarate dehydrogenase, Alpha-KGDH-E1, Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein: DOF25_ARATH
Sequence: MDATKWTQGFQEMMNVKPMEQIMIPNNNTHQPNTTSNARPNTILTSNGVSTAGATVSGVSNNNNNTAVVAERKARPQEKLNCPRCNSTNTKFCYYNNYSLTQPRYFCKGCRRYWTEGGSLRNVPVGGSSRKNKRSSSSSSSNILQTIPSSLPDLNPPILFSNQIHNKSKGSSQDLNLLSFPVMQDQHHHHVHMSQFLQMPKMEGNGNITHQQQPSSSSSVYGSSSSPVSALELLRTGVNVSSRSGINSSFMPSGSMMDSNTVLYTSSGFPTMVDYKPSNLSFSTDHQGLGHNSNNRSEALHSDHHQQGRVLFPFGDQMKELSSSITQEVDHDDNQQQKSHGNNNNNNNSSPNNGYWSGMFSTTGGGSSW
What is the function of this protein?
Transcription factor specifically involved in the maternal control of seed germination.  Regulates transcription by binding to a 5'-AA[AG]G-3' consensus core sequence.  May ensure the activation of a component that would trigger germination as a consequence of red light perception.
What are the official names of this protein?
Dof zinc finger protein DOF2.5, AtDOF2.5, Dof affecting germination 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACKA1_LISMF
Sequence: MHKIMAINAGSSSLKFQIFTMPGEEVLVKGLIERIGLPDAIFNMSFQNEKIKEIRAINNHGEAVEILLEQLKAHQVINDLSEITGVGHRVAHGGEDFVTSCVVTDEVVKGIEAVTNLAPLHNPANIIGIKTFRELLPNAVSVAVFDTAFHQTIPEENFLYALPYELYEKHHIRKYGFHGTSHKYVAGKAAEVLEKPLEKLKIISCHLGNGASVCAIEAGKSVNTSMGFTPNAGLMMGTRSGTIDATIIPYLVDELGYSLDEVMHMMSSESGVLGVSGISSDFRDIEIAAKEGNSRALLTLRMFTGQICNYIGAYASAMNGCDALLFTAGVGENSPLIRQMVTEQLSYLGVTCHVTKNNAGDMIISNDDEAVKVCIIPTNEELMIARDVEKYAKQTIS
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase 1, Acetokinase 1.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S35B1_HUMAN
Sequence: MASSSSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGAKQETFTFALTLVFIQCVINAVFAKILIQFFDTARVDRTRSWLYAACSISYLGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPLAKYLCVLLIVAGVALFMYKPKKVVGIEEHTVGYGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTLLLGMGILFTGELWEFLSFAERYPAIIYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISPMQWVGTVLVFLGLGLDAKFGKGAKKTSH
What is the function of this protein?
ATP:ADP antiporter.
What are the official names of this protein?
Solute carrier family 35 member B1, ATP/ADP exchanger ER, AXER, Endoplasmic reticulum ATP/ADP translocase, UDP-galactose transporter-related protein 1, UGTrel1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: AROQ_FRATO
Sequence: MDVLVINGPNLNLLGTRQPQFYGHKTLADINNDLLKIAKENNINIDFYQSNHEGQIIDKIQQTAAKIIIINPAAFTHTSVAIRDAFLAINKPFIEIHLSNIYNREEFRTKSFLSDIAYGCIFGFGPNGYTLALIEAINYINMKGE
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: IPL1_YARLI
Sequence: MSMKQLETSMSSVSLQEKKPTRIKIALHPQSKSEQNETDRASKIPTGRISTTQPQTYYRPTNLTKTPASQVSRRSSYTTDPPSPLTGITGFRNYSLDDFEIGKALGKGKFGKVYLVKDKKTGFVSALKCMEKKELVEGNVEKQFRREVEIQSNLRHTNVLRLFGHFHDKDRVYLILEYVVHGELYKLLRNQKRFTESTASSYIYQMSEALLYLHGKNIIHRDIKPENILLHFNDTIKISDFGWSVHAPSNRRSTLCGTMDYLPPEIVQSRPYDKNVDVWSLGILMYEFLCGAPPFEEPGGAQATYRRIVKLDLRIPPYVSADAADLIKRMLTLDPAKRFKLKDMHKHPWIVRLRPTWKYKVPKTASHERSA
What is the function of this protein?
Required for high-fidelity chromosome segregation during the later part of each cell cycle.  Acts in opposition to the phosphatase PP1.  Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles.  The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension (By similarity).
What are the official names of this protein?
Spindle assembly checkpoint kinase, Aurora kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and on elongated and disassembling spindles. Also associated with the kinetochore (By similarity).
Protein: MEP72_PSEAE
Sequence: MKKSLLCSTLALAVASAAQAAPKTVDIMVLYTPAATQTANGRDIDARIASYIEFANTAYEKSGVNLRLRLVHKQRLDWADYPTVTGANLDRFMRDPQVQRLREQYGADLVSLVNRSQNSGNGYITCGIGYMGSGDKNSGRFHGNAKDIAYNLTGVDCGLNTFAHEAGHNMGLRHSYEQDLESSYYDPRYAHSGTYEWSRGYGVQGRFATVMAYPHAFGTNKQAPFFANPRLVNAECANQPCGREEHADAVRALNSMATQIADFRPTKVPGTVNPGSGGDTPTPPDLPWCTKAKLGGLLGDGEFASMEGWRAWSGNAQLSLVNVAKGCRDNALLVDVRGFDLLVRPIAPLRAGSGYRLSGKVMLKAANTRETVRMALLSERADGALAYNPAQSVELSVSGNEFSRLEKTFDYRPAADQRNLYVAVWSDSGASLLVDEMNLQEAQAAPPSVPPAPKRIAYDFESGIGGWSGVHASARATRVASAGRLALEAYQRRYAGTGASTSLLGNLEAGRTYAFSADVRVGDGRGSQAMTYAYLYLESQGRPGEYLPLGYKVVENGRWASLRGQVQLPKGPIKRAELMILSGNQQESMFIDNVQLLQK
What is the function of this protein?
Metalloprotease with endopeptidase activity (PubMed:24279383).  Specifically cleaves on the N-terminal side of aspartyl, glutamyl and cysteic acid residues (By similarity).  Mep72 appears to be a secreted biofilm-specific regulator that affects the processing of a very specific subset of virulence factors exported by the type III secretion machinery as well as flagellar proteins.  Binds directly to ExoS and PcrV and affects the processing of these proteins in the biofilm secretome, but contrary to expectation, Mep72 seems to protect these targets against proteolytic processing/degradation (PubMed:25488299).
What are the official names of this protein?
Peptidyl-Asp metalloendopeptidase, Biofilm-associated metzincin protease, Metalloendopeptidase Mep72.
What is the protein family that this protein belongs to?
Belongs to the peptidase M72 family.
What are the subcellular locations of this protein?
Secreted. Note=Is secreted through the type II general secretory pathway (Xcp system) and undergoes processing during export.
Protein: VF015_IIV3
Sequence: MKYYSNPSFGGMDKNCKMSPRQVTIKAKELWLVNSTMTIAKKNLKKMEKVYDYLNQINIKTLSPESVIYYELWFMFIVECIHIQKIIIEYFQHEKNGEKQPITIGEIVYKIKMMLKPISVPFLKVKTGHVKLFIPEQIFNKF
What are the official names of this protein?
Uncharacterized protein 015R.
What is the protein family that this protein belongs to?
Belongs to the IIV-3 015R family.
Protein: YGDT_ECOLI
Sequence: MLSTESWDNCEKPPLLFPFTALTCDETPVFSGSVLNLVAHSVDKYGIG
What are the official names of this protein?
Protein YgdT.
Protein: SSAA1_STAAM
Sequence: MKKIVTATIATAGLATIAFAGHDAQAAEQNNNGYNSNDAQSYSYTYTIDAQGNYHYTWTGNWNPSQLTQNNTYYYNNYNTYSYNNASYNNYYNHSYQYNNYTNNSQTATNNYYTGGSGASYSTTSNNVHVTTTAAPSSNGRSISNGYASGSNLYTSGQCTYYVFDRVGGKIGSTWGNASNWANAAASSGYTVNNTPKVGAIMQTTQGYYGHVAYVEGVNSNGSVRVSEMNYGHGAGVVTSRTISANQAGSYNFIH
What is the function of this protein?
Not known; immunogenic protein.
What are the official names of this protein?
Staphylococcal secretory antigen ssaA1.
What are the subcellular locations of this protein?
Secreted.
Protein: HFQ_CLOBL
Sequence: MTKVVNNLQDIFLNGARKNRIPVTIYLTNGFQLKGFVKGFDNFTVILDSDGKQMMIYKHAISTINPAKPLLFVQNPNGDDYKDKE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: YIDD_PERMH
Sequence: MDRFLIKLIKIYKKFVSPALPNSCRYYPTCSSYAIQSIEKYGALKGSLKAVWRILRCNPFSKGGVDYP
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GRPE_LEUCK
Sequence: MKEQQKETEQNIEEINDETVTEQIETDVDTLEKEAEVDPQQVEIEQLQSDVKELEDKLLRAQAEIQNIQQRHARELQTVRKYDGQKLAGAVLPAVDNLERALQVESEDAVTQQIKTGVEMTLGTLVQALRDNGISATGEVGETFDPTKHQAIQSVASDDVASDQIATVLQKGYMIQDRVLRPAMVAVAK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDK_WOLWR
Sequence: MAIEKTLSILKPDAVKNNITGKINSYIESSGLKIIAQKMMLLTKKQAELFYEIHKDRPFFGELVEFMTSGSVIVQVLVGENAVSKYRQIMGATNPKQADKGTIRGDFADDISENRVHGSDSLENARKEIAFFFAECELV
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAK10_HUMAN
Sequence: MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTSDLKDWKRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSISVSDAPGSCLIDCNENTRKKSQKETESLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELMGPSESKPRGTSPLPAGQVLVRLQPQKQVKENKTQPQVAYQYWPLAELQYRPPPESQYGYPGMPPAPQGRAPYHQPPTRRLNPMAPPSRQGSELHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEPPTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAYGHRLIPYDWEILAKSSLSPSQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVRAICLRAWEKIQDPGSTCPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKAGKVIVELMAYENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVRTFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFDKNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQGQQPPLSQVFQGISQLPQYNNCPSPQAAVQQ
What is the function of this protein?
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle.  During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell.  Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA.  Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
What are the official names of this protein?
Endogenous retrovirus group K member 10 Gag polyprotein, HERV-K10 Gag protein, HERV-K107 Gag protein, HERV-K_5q33.3 provirus ancestral Gag polyprotein, Gag polyprotein.
What is the protein family that this protein belongs to?
Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system).
Protein: YHEU_ECOSM
Sequence: MLIPWQDLSPETLENLIESFVLREGTDYGEHERTLEQKVADVKRQLQCGEAVLVWSELHETVNIMPRSQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: CYAD_DICDI
Sequence: MTNNRLKNRKKPNQIHTISEEEEEEEPLFNNEDLQTQHLNSPSSDSISTSSSSSLSSVGGSVVGNNNSNSNGIDNNNSNNNNNNNNNNNNNNNNNNSNNNNNYTGNSIGGNDFKNKASSSSSTPTTSTGIGSSKFPNIKRKNSFSNRYDSGGGGSGSSRSNSFGGSNSSGGASKEFFYFDNDDMIQDDDLIPMLMQDQEHQLQTQYQNQQQVQQQQNIINSFINHENLKFPFSIIYTNKLHIWLSYFLFTFVLIFCCLAVGPLLWIELPPNSGCMWCRIFKLEWVISFMSLISAMFHYTIRRDMFPLYLSIIGFYHVLTYSEPFLEPFRVNNFFSLILTVICIFIAFYPKNKLRRQQASNHHQQQQQQQQQQRQRQQNNNRQPEKSIIKRIIQNEWFHSLIQILIVLGIVVLLFFSIFILALFMKDDKTFSGDVIDGNINSNNNNNNNNNNNINNNNIDNNNNNIKNNNKGFIEEIEQGEEQLELYLENAYHIFKELVFKKFISSSVVYLILITLLFCISLVYHWEVRKPYTLMALASMIPQLTQALYKVELTLTGVMDKGTMSHNVTPLGGGIFYILNVISYTSFYCGLAIDVVVASGEKYKRLKKRGEKYHRRLSTQINEQNAFVNKIYASGTAQLLQKVEFMQKFVDKILFSTLEISNRLQRLESSDQDIPSSLVDQLNDIQYQTNRSLLLLNDTKLILAIESGVISREDVSVNLFDFLEDVLERTSKDIKFNNIELVYKIDKDVPLNIILDPTALTQICFQLLSNAIKYTEEGEIGILIKRILRNDYEYQQEQQQPQQDNELPPFGTISEEDEEYNSNNPPPPLNQQQQQRQQQQQQEPKQIYLEISIFDSGPGMDDDELDICNQFQPFPDIGDEDDIEIKKKGSGLGLLICNKVLKSIGGDLIVERYLETGGCIFKCCIPVLVDPQPKENFTFQIPLSQETNELLSDLSVLVIDDNPYARDSVGFIFSSVFNSAIVKSANSSVEGVRDLKYAIATDSNFKLLLVDYHMPGCDGIEAIQMIVDNPAFSDIKIILMILPSDSFAHMNEKTKNITTLIKPVTPTNLFNAISKTFKLKEFSSVVDLVDLNAPDTSTQIPLKRNRLKFKIDFPFRLPETGKPIMRVLIGESDKSTQSKIQKVIESFGYFSTFVTDGTALISLSKKNYYDLVIVDLELQSTDGFECAQIIRDTHGEIFSNTIFVPKPISTNSNDDNNNNNNNNNNNNNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNSILTSSVDTDGNHIVSSSTSTSSSFPTRRSSIGSFQTASPSMTEISHRRRVKLPIIGIWHHSDIIPDDIIKKIKRVGFDGYCSFDNLEFYLQEFLLEFDRKRKSNILSPIRLFPNGSPSTNIYDYSSIISNLNQASGNNNNSSPISGILNENVISSPISLDLDLNSVSSIQSQSSSSSSSFQHNNQQQQQQQHQHQLTPTQQSIGGGNNGINQLSFSSQQSTPIFNQSQIQHQIISNRSKHSSLSSSTSSNGSGGSGGKSRFSIPMLPSSTNRDSSPHSSSKMALKRVQDLESVISKFVPIEFQQLIAPSGMENVYLGDAICKSITIFFSDIRDFTSTTEKMLVDDVIDFLNTYLAFALPSITDSGGFIDKFIGDAIMAIFPNSDMKLQAINAVKAAIRMMRSLDFMSISGFRFSSVETGVGINTGKTIIGIVGTENRMEPTALGDAVNLASRTEQLCKEYQSRILITQFTMEAIGTSIDEFVIRLVDSVTVKGKSEAVNIYEVIDGEREDKRVLKMKILPWYQNGMDLYKRHCYEEALSYFQLCTEIMPNDKPTLIYIQRCIQNIKTLELQQIQLQQLQRQQLLQQQQQQLLLQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSQNIQQPQSQQSQYVQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQLQQQQQHQQQKQPSPQQQQQPQQPQQQQQQQIQNQYQHQLQYQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHQQQQFQQQSQQSQQQSQQQQQQQQQQSQQQSQQQSQQIQKKSQHPHSQQIQSQRHQSQPQNVDTNVKTKPQQ
What is the function of this protein?
Through the production of cAMP, activates cAMP-dependent protein kinases (PKAs), triggering terminal differential and the production of spores.
What are the official names of this protein?
Adenylate cyclase, terminal-differentiation specific, ACR, ACB, ATP pyrophosphate-lyase, Adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HEMA_I000X
Sequence: MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQKETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSIACKRGPDSGFFSRLNWLTKSESTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWTCQRGNIRCNICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: INKA2_HUMAN
Sequence: MTMESREMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPVPGSPEGPRTQCEHPCWEGGRGPARPTVCSPSSQPSLGSSTKFPSHRSVCGRDLAPLPRTQPHQSCAQQGPERVEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGEKGETGGAREPKGEKGQPQELGRRFALTANIFKKFLRSVRPDRDRLLKEKPGWVTPMVPESRTGRSQKVKKRSLSKGSGHFPFPGTGEHRRGENPPTSCPKALEHSPSGFDINTAVWV
What is the function of this protein?
Inhibitor of the serine/threonine-protein kinase PAK4.  Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
What are the official names of this protein?
PAK4-inhibitor INKA2, Induced in neural crest by AP2-alpha protein-related homolog, HInca-r, Inka box actin regulator 2.
What is the protein family that this protein belongs to?
Belongs to the INKA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARGE_ALIFM
Sequence: MKFPEFKDYYQQLISTSSISSTDSSWDEGNAEVINKLAQWCEDLGCEVEIEEIEKGKLNLLAKLGSGEGGLLLAGHTDTVPYDEGRWNYEPHALTEANDRFYGLGTADMKGFFAFILEAIKNINWKDQSKPLYILATCDEETTMLGARHFASNTKIQPDYCIIGEPTSLKPIRGHKGHVANAIRVTGKSGHSSDPAHGVNALEIMNEIMFALMTLKNKLVKEYHNPGFSIPYPTLNLGHIHGGDSPNRICGCCELHYDVRPLPGISLDGLDNMLRDALKEVEAKWPGRIDITPLHEPIPGYECSADSPIVTSTADICGQDVETVNYCTEAPFLQDLCPTLVLGPGSIEQAHQPDEYLAFSFIDPTISVLSKLMYKHCF
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_MARMS
Sequence: MARFFRRRKFCRFTAEGVKEIDYKDLDTLKGYITETGKIVPSRITGTKARYQRQLATAIKRARYIAILPYTDSHFN
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: ATPA1_BURP0
Sequence: MQLNPSEISELIKSRIQGLEASADVRNQGTVISVTDGIVRIHGLSDVMQGEMLEFPGNTFGLALNLERDSVGAVILGEYEHISEGDIVKTTGRILEVPVGPELVGRVVDALGNPIDGKGPVNAKLTDAIEKIAPGVIWRKSVSQPVQTGLKSIDSMVPIGRGQRELIIGDRQCGKTAVAIDTIINQKGKDLICIYVAIGQKASSIMNVVRKLEETGALEYTIVVAASASESAAMQYLAPYAGCTMGEYFRDRGQDALIIYDDLTKQAWAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVSEEYVEKFTNGEVKGKSGSLTALPVIETQAGDVTAFVPTNVISITDGQIFLETDLFNAGIRPAINAGVSVSRVGGAAQTKVVKKLSGGIRTDLAQYRELAAFAQFASDLDEATRKQLERGRRVTELLKQPQYQPLQVWELAVSLFSANNGYLDDLDVKDVLPFEKGLREYLKTSHADLIKRIEDTKDLSKDDESALHAALKDFKKSGAY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS17_CAMJJ
Sequence: MAFKREIQGVVVKIAGEKTASVLVERKVVHPRYRKIVKRFKKYLIHDERNEVKVGDTVVAVECRPLSKRKSFRLKSVLATGVE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: NUDL_SHISS
Sequence: MEYRSLMLDDFLSRFQLLRPQINRETLNHRQAAVLIPIVRRPQPGLLLTQRSIHLRKHAGQVAFPGGAVDDTDASVIAAALREAEEEVAIPPSAVEVIGVLPPVDSVTGYQVTPVVGIIPPDLPYRASEDEVSAVFEMPLAQALHLGRYHPLDIYRRGDSHRVWLSWYEQYFVWGMTAGIIRELALQIGVKP
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: SMAP_CHICK
Sequence: MSSARESQARHGLKRAASPDGSGSWQAADLGNEERKQKFLRLMGAGKKEHTGRLVIGDHRSTSHFRTGEEDKKMNEELESQYQQSMDSTMSGRNRRHCGLGFSEFQEGEEEAAGHSSDHESSEDSESGSDSKQDESAEELQAAETHDEAAVPETKKEAKSNYKMMFVKASGS
What are the official names of this protein?
Small acidic protein.
What is the protein family that this protein belongs to?
Belongs to the SMAP family.