PharMolix/UniProtQA huggingface dataset:
Protein: DCUP_RICCK
Sequence: MKQLLNPLKGNSDKIPVWFMRQAGRYLPEYKKIRETIKNFLDFCYDVNKATEVTLQPIRRYHFDAAIIFSDILVLPHALGWEVDFKENIGPILRQFRSQEDFKYLQSDTNNKLEKVYKIIKKVKKELPSTTSLIGFAGSPWTVMSYMLEGKGKQDFKTSKKFVYENKALSKELLNFLIDKTTYHLINQVESGANILKLFDSCSGVLAEEEFTEFVIEPTKKIILKVKEVLPKTPIIAFPKGAGLLYEKFIKEVPIDILAVDQMIPLEKMKEWSDKVIVQGNLDPVVLLTNKEIIKEKAYEILQVMEGKNFIFNLGHGILPETPIENVEFLTEYVRSFKK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_SALNS
Sequence: MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRKRGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPEDVWTLNVKNEGKLSFMTQTTLSVDDTSDVIDALRKRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGRTAFLIDDAADIQEAWVKEAACVGVTAGASAPDILVQNVIARLREFGGGEAVTLEGREENIVFEVPKELRVDVREVE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: GET1_KLULA
Sequence: MESWLLVILAFLVLERLWPLIDSLIQRFAQANSTKLKELMHQRQAILAEQKEISAQDQYVKWTKNNRTLEKINKQIEEEKKQLLSQVDRTKASLKKVKLVLITVPFTILKFYKGKMPIYDLPKGLFPNYLQGLFQHGWVYLALGPLNIKKVGDGTHVTVSLAIWLFALLKVVSTLGNIWESLTAPAIPAPTITTDPIDQTNESEKPPVDQPVD
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
What are the official names of this protein?
Golgi to ER traffic protein 1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: DEF_METI4
Sequence: MILKLVLYDNPILRKKGMPIDSFDDRLKRLVQDMLETMAYYKGVGLAAQQVGLNLQLAVIDVSGSKLSSSLLIGGKPAMVEEHMPLFLINPTLSYTQSKEISNEGCLSFPGLRIDVPRSKRVKVKTFDLEGRPWYFEAGGFLSVAIQHEFDHLQGKLFIDYLSAEQKKAIKEELEKIKRGEAILSVKETD
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: PHNC1_ROSDO
Sequence: MLRLEKLVKTYKTGDQALKEVDLEIPQGQVLALIGPSGAGKSTLIRCVNRLVEPSSGKVYLGNVELTGLSSSALRRERRRMGMIFQEYALVERLTVMENVLSGRLGYVGFWRSFMRRFPQADVDEAFRLLDRVGLAHMADKRADELSGGQRQRVGICRALIQDPALLLVDEPTASLDPKTSRQIMRLICELCRERGLAAIINIHDVALAQMFVQRVIGLRFGAMVYDGPPEGLTPDRLTEIYGEEDWEATIEQVDDDEIEAAE
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PCBD_PROMT
Sequence: MQSYGNPDVTYEWWAGNSVVTSRSGRFIASHIGHTGLIAFAAGGSTLWELARYNPEIPMGHQSSLFLGHLAAFGVGFDEAGAWTGVGVAAVAIVHLVLSMVYGGGALLHAVYFEADVADSEVPRARKFKLEWNNPDNQTFILGHHLFFFGMACIAFVEWARIHGIYDPAIGSVRQVNYNLDLTMIWNRQFDFIGIDSLEDVMGGHAFLAFAELTGATIHMVAGSTQWENKRLGEWSKYKGAELLSAEAVLSWSLAGIGWMAIVAAFWAATNTTVYPIEWFGEPLKLQFSVAPYWIDTADSTGITAFFGHTTRAALVNVHYYFGFFFLQGHFWHALRALGFDFKKVSEAIGNTEGATVRVEGAGFNGRAPR
What is the function of this protein?
The antenna complex functions as a light receptor, it captures and delivers excitation energy to photosystems II and I.  The Prochlorales pcb genes are not related to higher plant LHCs.
What are the official names of this protein?
Divinyl chlorophyll a/b light-harvesting protein PcbD.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. IsiA/Pcb subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: COX2_APTAU
Sequence: AICSLVLYLLTLMLMEKLSSNSVDAQEVELVWTILPAIVLILLALPSLQILYMMDEIDEPDLTLKAIGHQWYWTYEYTDFKDLSFDSYMIPTSELPLGHFRLLEVDHRVVVPMESPIRVIITAGDVLHSWAVPTLGVKTDAIPGRLNQTSFITTRPGIFYGQCSEICGANHSYMPIVVESTPLPHFENWSSLLSTSSSL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y1579_BORPA
Sequence: MQAFVQFLGSNPYILLFLTIGLAVWVGKFSIKGYGLGAVAAAIVVGCLVATVGAAYGVKFHLDEFAKSLLYYLFMYGVGLRVGPSFVNALNKESINYAILAIIAPILGLAIVVLGTQFFGLPLGAAGGMLAGSQTMSAAIGSAEQAVSAGVLSLGSESPEQISAMIALSYGITYIWGTVGIILLCKYLPRIWGVDAKAAALEFEKAHGVPNVDDAGLTAFHPFDLRAYRVENPESIGKTVQQFRTRFPQYQVVNVERGDQLLGPSAETVLQQGDVVALGGRLEEMTANMGMLGPEVPDARALNIPLDQAEILVTNKEVTGRPLKTFRGSELAGQIQLQRVERSGVPLPIGLETTLQKRDVLFVTGLQPAVSKAGEIFGVIARHSSATDLLTLSFGMILGFLIGLIEVPAFGAKVGLGNAGGLLLSGIIVSSISSRLRFFGNTPNAARNILEDLGLIGFVAIVGINAGADLLTQLTGAIALKIFIVGFLASTIPPIIVWAIGFHIMKINPALLMGATAGARSHSGPAREAAKEVGSSVPWLGFPVGYAVSGVLLTVFGYFAMVLAH
What are the official names of this protein?
Uncharacterized transporter BPP1579.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: METK_SACS2
Sequence: MRNINVQLNPLSDIEKLQVELVERKGLGHPDYIADAVAEEASRKLSLYYLKKYGVILHHNLDKTLVVGGQATPRFKGGDIIQPIYIIVAGRATTEVKTESGIDQIPVGTIIIESVKEWIRNNFRYLDAERHVIVDYKIGKGSSDLVGIFEASKRVPLSNDTSFGVGFAPLTKLEKLVYETERHLNSKQFKAKLPEVGEDIKVMGLRRGNEVDLTIAMATISELIEDVNHYINVKEQVRNQILDLASKIAPGYNVRVYVNTGDKIDKNILYLTVTGTSAEHGDDGMTGRGNRGVGLITPMRPMSLEATAGKNPVNHVGKLYNVLANLIANKIAQEVKDVKFSQVQVLGQIGRPIDDPLIANVDVITYDGKLTDETKNEISGIVDEMLSSFNKLTELILEGKATLF
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase 2 family.
Protein: AROA_DESAP
Sequence: MTLKITPARGLRGEAWVPGDKSISHRVVMLGSLARGETAATNFLPGEDCLATVRCFRALGVEIEGPDGDTIRIRGRGPEALTEAPDVLDAGNSGTTMRLMLGILAGQPFFSVITGDASLRRRPMGRVTGPLQEMGATILGRRNANLAPIAVAGGRLSGIRYRLPVASAQLKSALLLAGLFADSPTEVTEPVATRDHTERMLAAFGALVARRGSSVTVAPSPELCGREIRIPGDISSAAFFIVAALITPESDLVLKDVGVNPTRTGILDALANMGARISVSRPRESGGEPVADIRVRSSALRGTVIEGALIPRLVDEIPVLAVAAAYADGETVIRDAAELRVKESDRLAATRKELSTLGADIRETPDGLVIRGPRRLTGGSCNSHGDHRIAMAAAVAGLAASDVTIIRDSNCIDVSFPGFAHALNSLRLE
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRK_LACP7
Sequence: MYTVELGKLVEKMNLENCTPEIDISSIQITQPDVNRPALQLTGFFDYFDSDRVQIIGNVEHAYMQKMEKDHGLGIMKKLMSFKMPCIVFCRGIEVSEDFKEVAIEEGVPIFRTEKTTSSFMAEVIRWLKVELAPRISIHGVLVDVYGEGILIMGESGIGKSEAALELIKRGHRLVTDDLVEIKKVSDDTLIGTAPDITRHFIELRGIGIIDVKTLFGVESVKNTQSIDLVIKLEEWNRDKEYDRLGLEEQYIEFLGNRVVCHNIPIRPGRNLAVICESAAVNYRQKKMGYNAAQELYNRVTNNLLKKSK
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: Y059_NPVAC
Sequence: MYQIPDMLYNEKMPPRAKKLFVETFTKYHKMNGGDEDIAMHKARKALEEKYVKIDTLQNLGFRAKPPTR
What are the official names of this protein?
Uncharacterized 8.2 kDa protein in LEF8-FP intergenic region.
Protein: ACDA2_METAC
Sequence: MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKAKELGPMGPTAMAGLASYRSWNLLLLDRYEPVLTPMCDQCCYCTYGPCDLSGNKRGACGIDMAGQTGREFFLRVITGTACHAAHGRHLLDHVIEVFGEDLPLNLGESNVLTPNVTICTGLSPKTLGECRAPMEYVEEQLTQLLATIHAGQESAEIDYDSKALFSGSLDHVGMEVSDIAQVSAYDFPKADPEAPLIEIGMGSIDKSKPLIVAIGHNVAGVTYIMDYMEENNLTDKMEIAGLCCTAFDMTRYKEADRRAPYAKIVGSLAKELKVIRSGMPDVIVVDEQCVRGDVLSESQKLKIPVIASNEKIMMGLPDRTDADVDSIVEEIKSGAIPGCVMLDYDKLGELIPKIAEVMAPIRDAEGITAIPTDEEFKVYIDKCVKCGECMLACPEELDIPEALEYAAKGSYEYLEALHDVCIGCRRCEQVCKKEIPILNVLEKAAQKSISEEKGWVRSGRGQASDAEIRKEGLNLVMGTTPGIIAIIGCPNYPAGTKDVYLIAEEFLKRNYLLAVSGCSAMDIGMFKDEDGKTLYEKYPGTFAGGGLLNTGSCVSNAHISGAAEKVAGIFAQRTLAGNLAEIADYTLNRVGACGLAWGAYSQKAASIGTGCNIYGIPAVLGPHSSKYRRALIAKNYDESKWKVYDGRDGSEMTIPPAPEFLLTTAETWQEAIPMMAKACIRPSDNNMGRSIKLTHWMELSKKYLGVEPEDWWKFVRNEADLPLAKREELLKRLEAEHGWEIDWKRKKIISGPKIKFDVSAQPTNLKRLCKEA
What is the function of this protein?
Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.  The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
What are the official names of this protein?
Acetyl-CoA decarbonylase/synthase complex subunit alpha 2, ACDS complex subunit alpha 2, ACDS complex carbon monoxide dehydrogenase subunit alpha 2, ACDS CODH subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the Ni-containing carbon monoxide dehydrogenase family.
Protein: ACD11_CAEEL
Sequence: MHRIGNAVRMASSSSANATITARHTQYSHAKTGGFSQTGPTLHNPYKDDPILDRTLRRLLPESEYMRVAADLSKFGDRITSEVEHLGRQAELEQPRLEHQDAWGKRVDKLIVCNEWHKLKQICAEEGVISIGYEDSVDPFVRRIHQVAKLFLFSPSAGLVSCPMAMTDGAVKTLTSLNLYGKHKLATEAVDRLRSRDPSKAWTSGQWMTEKKGGSDVAGGCDTYAVQIDKDTYRLHGYKWFSSAVDADVALTLARIVDSDGNALEGSRGLSLFLLKIRDESGNLNGIQMVRLKNKLGTKQLPTAELLLDGAIAERIGDQGRGVAGISNMLNITRIHNAVASLGYMRRIISLARDYSTKRVVFGQTQSKWPLHTTTLAKMEVDTRGSMLLLFEAARLLGLSEAGKSSDVEAMMLRLITPVLKLYAGKQAVPMVSEGIECFGGQGYMEDTGLPTLLRDAQVTPIWEGTTNVLSLDVLRVFSGKENILLAFGKRVEQLLGNTKTEDEKLKKSKEAVESALKQLQKLLVKASDSAIQGETRIDSVARHIAFTIARIYSGALLIDHASDSSVANQSDIEVAYRYCCEQPLIDLRWEWFASERVKADREIVFDNFTALEKSKI
What is the function of this protein?
Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7.  Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat.
What are the official names of this protein?
Acyl-CoA dehydrogenase family member 11.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
Protein: YBEY_FRATT
Sequence: MKRKLKMDNLNINFINDDEHPIPSQDLLLKCLQLVANKHHISHAEVNLNIVSNDEIQQINKQFRNKDKPTNIISFEFEKPQGLPDDIANDFLGDIVIAPAVLENEAKEQNKELNDHWQHIFIHGLLHLLGYDHQDDQEAEVMENLEIQLLAQLGIANPYIEQENQNGR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB_ASPFU
Sequence: MREIVHLQTGQCGNQVGAAFWQTISSEHGLDESGLCNASSDQQLERMNVYFNEVGNSKYVPRAVLVDLEPGTMDAIRSGPHGALFRPDNFVFGQSSAGNNWAKGHYTEGAELVDQVIDVVRREAESCDYLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVLPSPKVSDTVVEPYNATLSVHQLVEHADETFCIDNEALYDICTRTLKLSSPSYGDLNHLVSTVMSGITASFRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAQSFRAMSVPELTQQMFDSRNMMTACNFQNGRFLTCSALFRGKISMKEVDDQMLSIHTKNSGYFVEWIPNNVQTALCSVPPKGLKMSATFVGNSTSVQELFQRVATQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLMSEYQQYQEASISDGEEQPYAEEAAYEAEE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: CARK1_ARATH
Sequence: MGCFGCCGGGEDFRRVSETGPKPVHNTGGYNGGHHQRADPPKNLPVIQMQPISVAAIPADELRDITDNYGSKSLIGEGSYGRVFYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSVVTWATPKLSEDKVKQCVDARLNGEYPPKAVAKLAAVAALCVQYEADFRPNMSIVVKALQPLLNPPRSAPQTPHRNPY
What is the function of this protein?
Receptor-like cytoplasmic kinase (RLCK) that triggers abscisic acid (ABA) signaling by phosphorylating and activating ABA receptors (e. g.  PYL8/RCAR3 and PYR1/RCAR11), which in turn repress ABI1, a negative regulator of ABA responses (PubMed:29928509).  Promotes drought tolerance (PubMed:29970817).
What are the official names of this protein?
Receptor-like cytoplasmic kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: TGT_SHEHH
Sequence: MKFELDTTQGRARRGRLIFERGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFLDPEKSMQIQDSLGSDVVMIFDECTPYPATEDEARKSMQMSLRWAQRSRDEFDRLENPNSLFGIIQGGVYEDLRDESLNGLVDIGFDGYAVGGLAVGEPKEDMHRILEHVCPKIPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTSPLDDKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQRLMEGLRGAIETGTLDAFVTEFYTSQGREVPEVPELTD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: MNMG_BRUSU
Sequence: MSSAEALAFDVIVIGGGHAGCEAASAAARAGARTALVTHRFDTIGVMSCNPAIGGLGKGHLVREIDALDGLMGRVADRAGIQFRLLNRRKGPAVRGPRTQADRKLYRLAMQQMITEQENLTVVEGGAADLVCDGERISGVTLADGRVLKCGAVVLTTGTFLNGLIHIGEKRFPAGRMGEKPALGLSERLLSFGFTLGRLKTGTPPRLDGRTIDWQSLDMQSADEEPVPFSLMTDRITTPQIECGITRTTPETHDIIRANLHRSAMYSGSIEGIGPRYCPSVEDKIVKFGDRDGHQIFLEPEGLDDDTVYPNGISTSLPEDVQLEILKTIPGLEKAVLLQPGYAIEYDFIDPRELKRSLETRKVCGLFLAGQINGTTGYEEAGAQGLLAGLNAARRAAGSEPVILQRTEAYIGVMVDDLTSRGVSEPYRMFTSRAEFRLSLRADNADQRLTPLADEVGILSKERRKRYLTRETALSHARMVTQSLSITPNLAGYYDLRLNQDGVRRSAYDLLSYPDINLDRLIAIWPELASIDPVTREALEIEAQYAVYMERQQSDIAVMEREERLLIPSGLDFDAISGLSNELKQKLKQRKPETIAEAQRVDGMTPAAVALLIAQIRKFGGRQKLAAETLEGKGAA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_STRGG
Sequence: MRIHVVDHPLVAHKLTTLRDKRTDSPTFRRLADELVTLLAYEATRDVRTELVDIETPVTPTTGVKLSHPRPLVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRNEETLKAETYATRMPEDLSGRQVYVLDPMLATGGTLVAAIRELIERGADDVTAVVLLAAPEGVEVMERELAGTPVTVVTASVDERLNENGYIVPGLGDAGDRMYGTAE
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: GTR1_HUMAN
Sequence: MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
What is the function of this protein?
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690).  Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892).  Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690).  In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
What are the official names of this protein?
Solute carrier family 2, facilitated glucose transporter member 1, Glucose transporter type 1, erythrocyte/brain, GLUT-1, HepG2 glucose transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Melanosome. Photoreceptor inner segment. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Protein: CETA_ACTSX
Sequence: MANQWQAQAEQTITYEVQMTDGVLDPSNRALLDAGATVRTDQPRRFIVIDANVHEIYGDALRKYLAHHNCEYRLCVLSASEEAKTMESVFTVVDGLDSFGISRRHEPIIAIGGGIVLDIAGLAASMYRRSTPYVRVPTSLIGLVDAGVGIKTGVNFGSHKNRLGTYFAPTAALLDRGFLDTVDDRHISNGLAEILKIALVKDAELFRLMEEHAELLLAERLTGRTPTGDVVAREVFSRAVGGMLEELEPNLWEQELERLVDYGHSFSPTLEMRALPALLHGEAVTVDMALTTVLAEARGLVSTSDRERIFQVMRRLRLPVWHPLLEAGLLEHALRETTRHRDGLQRMPIPVGIGGARFLHDLTVAELTGAAESLRELGGGE
What is the function of this protein?
Catalyzes the cyclization of D-sedoheptulose 7-phosphate to 2-epi-5-epi-valiolone.  Involved in cetoniacytone A biosynthesis.
What are the official names of this protein?
2-epi-5-epi-valiolone synthase, EEVS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. EEVS family.
Protein: RL1D1_PONAB
Sequence: MEDSASASLSSAAATGTSTSTPAAPTARKQLDKEQVRKAVDALLTHCKSRKNNYGLLLNENESLFLMVVLWKIPSKELRVRLTLPHSIRSDSEDICLFTKDEPNSTPEKTEQFYRKLLNKHGIKTVSQIISLQTLKKEYKSYEAKLRLLSSFDFFLTDARIRRLLPSLIGRHFYQRKKVPVSVNLLSKNLSREINDCIGGTVLNISKSGSCSAIRIGHVGMQIEHIIENIVAVTKGLSEKLPEKWESVKLLFVKTEKSAALPIFSSFVSNWDEATKRSLLNKKKKEARRKRRERNFEKQKERKKKRQQARKTASVLSKDDVAPESGDTTVKKPESKKEQTPEHGKKKRGRGKAQVKATNESEDEIPQLVPIGKKTPANEKVEIQKHATGKKSPAKSPNPSTPRGKKRKALPASETPKAAESETPGKSPEKKPKIKEEAVKEKSPSLGKKDARQTPKKPEAKFFTTPSKSVRKASHTPKKWPKKPKVPQST
What is the function of this protein?
Regulates cellular senescence through inhibition of PTEN translation.  Acts as a pro-apoptotic regulator in response to DNA damage.
What are the official names of this protein?
Ribosomal L1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family. Highly divergent.
What are the subcellular locations of this protein?
Nucleus, nucleolus.