Protein: CCTN_TALIS
Sequence: MYTDKFRFKTGVSSFQILLAWTVLLKDYIGSSGVSFSFSDSTQCHKGTGKIDLELDEHDTIGLLSRRIKEQLLVKSDSNEYLSFKTHLDISSGEPENLNGHLIGSTNGHKKQWENDSADDKRGQHPREIVDWTIKCVLSEDGRGMKTTAIPKLSTASSRQGLRLMYQLEHVLRHIHLSTEGTLVYKIDTATKSDLNDIWKWNFNNPPLSERTVLEIFTENVQRYPTATAVNAWDGDLSYQELDRLSTEFSFHLAYAGVKRGNIVPLFFEKSMWTPVAIWAVIKTGAAFVLLDEVLPESRLQQLGQVIRQEIIVALASSSQESRAKLLGTQVIIIDSYYLETAASVPSEFKTQPQIQPSDLIYIVFTSGTTGVPKAVMIQHSNVSAFARSLRTISDVGPNSRIVALSSYAFDVSLGNLFLSLLSGCCLCIPSSWECRNTVPRVLQDYQITHAQMTPSISKMLRPCQLSTLEVLELSGEQCTEDVLARWQETPIRVMNTYSPAECTITTVGNGNVLTSSKSSIIGKGLGNCCWVLDPIDHDRLSPVGGIGELVLEGPSVGMGYLHDPRATALKFFEDPEWLLKGLPGVSPGRKGRLYRTGDLVRYTEDGSIDFVGRRDTQVKIRGQRVELGEISAHLQQLVHPSIWCSPEVVKVSSGTELLVVFLVVTEDEVGNGTASILRSTLRVTVDLVDSELRSRLPPAMVPGAYACIKDIPLTLTGKTDHRKLREIGLSLAADMLIFPSNKQESYATNGDRQNRGLHTTLNGNGYQEQNGHAHTHAHTNGDTNGHTNGYVNGSHSHTNSRNKTQKYGHVTYDGTEEEYKIQTLKEIWSDEFHVDIESITLSDSFFAHGGESLTAIKMVGVAFEKGIQLDVPTIFRHPQLSDLVSNCKMSATASPDHPKPFSLLEGEIIPVEAVEACGTCLDNIEDVYPCTPLQEGLITASISKSTAYVGQKAFLLPDGINFERLALAWQRVVQTHQILRTRIFDTESHGLLQAVLTDGKVFLGIQKRDLKSYLEDDNDRKMGLGTELCRCAIVRESGCSYFVLTMHHAIYDGWTLPRIGSEVFKAYQGVRVEPNMGFNAFIKHIKSLPSQTANKFWAHQLANPGESAVFPIVPLYIQEPKSDSTVSKRFPVPQNANSGVSMPSLLRSAWALLVSKLSDSNDVTFGATVSGRNVPIYGIKDLLSPTISTVPVRVKIDKDSNIETFIATVQDDSLSAIPFENFGLQNIRKINTDTREGSKFQTLFVVHPPNSTTPDQTLNLSLADHELKDILENLDISSVLSNFNEYGLMVIVTQEQDSLIVQASYDSRVLETDQVILLLDQFAHVAEQIGQPANLACKVQELQFASGKDVETIWTWNSTRVPGLKECIHDVICRTIAVQPHGQAISAWDGNLTFEELNVLSLRLAHILRSKGVGRGSLVPICMEKSKWATIAMLGILRIGAGFIAMDVRHQPRQRLQTIADAVNSKWIVTAGPATELVPDVSEGVIVCDQDLQIETSDFPVPLEPVCSASSDTAFVVFTSGTTGVPKGIVITHENFCSTIQHHAHQLKISKESRIYDYASYSFDIAVHNSLMAMCLGACLCIPSEDERENDIEGSFERLQANWTDITPSVARLVDPTGVPGLKTLVLSGEAVRKDLVERWATKVNLINAYGPAECQICTIQENIIDPQQAAHIGRAVGCTAWIIDPENDSLCPIGAVGELVIEGPIVSPGYLNATRDAFIQDPKWLIEGSASIPGRRGSVYRTGDLCRFRPDGTIIYISRATTQIKINGQRIELEDVEFYVQQAMATPGQVIASVVNFDGVNHLTAFLAPVPTLKTNDKFHGLGKDVEPTVELIPPPIGLQNKLKDALPAYMIPTVFLKISHIPLTTTRKIDRRQLNDCASRISRDDLIALDQEGTGPVKIELSEKQENMARLWAQVLKLNSSKIGLHSDFFRLGGESISAMRLVKYARKEGLVLTVADIFRHSRFDQLVMIATELTSRENTAEYFNGKLQPFALVPMNHRDSLISTAAMACNLPSDDIIDIYACTPFQEGVFALTASNSSAYVQHTELRFSDELNLDQVLDAWVSVIAANPILRTRFIQSEDAKLMQVVVRPQKQAWKWYYSPQEYLSEAENIPFGLGDPLFCFGLVRHGSTSSPGHTLIWTLHHAVYDAWTMDLILRQVSSCYYGEKQAESGPDYSVFVDFLRHQESESANWWKSYLSGSSDASIFPKMPISAAESQIDNTIRKEFAMPNIVPPGYSPAVILRAAWAAAVARYTGDESVLFGETRLGRNVPVSGIDKLLGPTIASVPLLVHIDREQTIGSLLYAIREDGLQMQPFEHLGLQNISHISEDTKAACKFQTLLVFLENAEDVDSSSIFKIDETIDDIRNFNSYYLLVYFTLNQKGLVAQAVFKDSAISSGQVEFLLEQVQSIFSKLCESPLDTPLRSLDLASEQDLAKIWNWNATSAEAVDKFVHELIAEKARQHPNKLAVFAHDGQITYKELDDYSTNLASQLIGRGIGLGCFVPLCFEKSAMVPVCMLAVIKTGAAFYVMDVSYPEGRLKLITETLKASLMLASPSQQWLAKRLAGNILVVDSVCCTDNTYRSSHPVIEDPSRNTNRLMYVCFTSGSTGLPKGVMVTHKNISSAAVAQTQDLDFDPEDRVYDFSSHAFDANIWHFYLGFIVGACVCIPSQEDRIGNLAGSITFFQSTALFLTPSVARTLDPKELPTVKRLYLGGEAVTPLDVSKWVEHLDLWGAYGPTETTPLCIFTRLHSPEFASNIGKGVGVRSWICNPNNNEELMAIGAVGEMVNEGPLVTQGYYEQPEKTAKVFIENPEFLLRGYKEIPGRRGRLYRTGDLVRYAFDGSIEYLGRADTQVKLRGQRVEFGEIEYHLNNALPGTSSICEVIIHPSSRMPMLAAFCTLSSSMDTLNETGARAYLCKRVPPYMVPEFFFTIPEIPKNPSGKVDRLKLRSFGPQVLLERSTSHEEGSVTERVHGPLTEMETTLAELWATAVDHDVTWLGMESEFADVGGDSIAAMKLSNLARRHELSLTVKDIINSSNLAGMAIKIQPIHESFASPQPFSLLPPSRIDQTVARAAMTCGVSIDSITDIYPCTPLQVELFSLTMKQPQAYIKRSVFEVPTSVNFEKLIESWDSVFDINAILRTRFVEVDDLGLLQVVIKGHQRKKYGSLDSFIQACSQERLDFGSPLSHLAVVEDSVALKIAWTIHHALYDEWSTLIIEEQLRQAYRSRCIPRPPDYSEFVRYIRTNNHEEARGFWRNSLAGCISAKIYPELPVGNYQVRPRKAFKRSLQYSARPGVNIQATIHAAWALIVSRLSASDDVVFSTTLAGRNAPVAGIEQMVGPTITPVPIRVKLGNQKQSVQSMLDMIEKDIAKMAPYQHIGTKNIERINDDTRAACKFRTLIVVTPTSYSTTHELQDIKTETYGVNSEEGQAFHTIPLVLFFFPGESGLDLEIVFDPVILHEREIERLTGRLETVLSAFSTANSVSDIQCIGREDLEDVWKWNAILPSSSKKLLHEDILECVQRAPDKVAIEAWDCKITYSQLDQLSENHAVHLNNYNVRKGTVVPILSLKSGLVPVAALAVLRAGGTLLPLDITQPVQRLKMIIDQVKPNVVMAGLSSIGIASQLCENVIVIKSCVDITPCAHGDAVYFETPSPDDVACILFTSGSTGIPKGVKQTHRGLSSAIKHQARESGFNENTRAFEFASYGFDVSWNMIFKVLAVGGTLCVPEEEERQNDLARALNRTAATLTELTPSVARLINPQQLTSLTTLILSGESVDPREFAHWKPQNHHQLMPVGAIGEIIIEGPIVGSGYYNNENLTSASYVHDVPWLRNDHDGNDARTSRVFKSGDLARFDSKGNIHFIARKDLQVKLNGQRIELEEVQHHVRNLMHDFVGPVISCVLGDSKQRSDQKLATFLVNKHGNTQGTCLAVPEEKAVEQLETLDERLREMLPKYMVPSIYYFVTAVPRTNNGKIDMKRLVEVAAMARPDQIYRGRTDRQRVRRIPSTPTEMKMQQLWAAALEVPIAEIGADDTFFNLNGDSISAMKLVAGARSEGFDLRVSDVFETPRLSELATKIAPRITKKQLAVSTIRPFELLGESANIVAIRSEVAAKCGMQDPGAVKDVYPCTPLQESMLAATIRDPRAFISMRVYRIRQGVDLVRLENAWATVVAQHPILRTRLVDLEHHGLTQAIFEESHIIWQTYVDMDSFLRHYEEQKMGPTTTLTRWALIDEADDWKLVWTIHHAIYDGWVLPIVEEEVRKTYFGSEQDKQYLDMKPLVKYILQEEKAKSIDFWARLLAGSEESIVYPPLPSHKYESSPATYLERTISADLSSSRGINLSALLYGSWSVLVSHMTGIPKVSFGAILTGRNAPVDGIDRMIGPAVTTVPILVDANPSFSVRKFMDRLQDMTVQRMPHEHLGVHAIRRINDACEAGCRFQTVLVIQPPGGNGHDTSNIQDSFLMEEVDETTIEGFPDQHSVLNQYGLMIEILPRGKEIKVRASFDSNLISTSQLSKTISRWERIINQISQTLSQGVHTTIQSLDSLSQQDIEEIWTWNKELPDVVDDRFVFEIIQEIAGRHPDALAIDAWDGQLTYRDLESLSTRVSELLVSFGVGPGSFVPLLFHKSMWTNVSMLGVLKVGAAFVPLDFSHPEGHLRAVMQPLNADIILCADNTRDRAARLSRRAIIVDERSLNADHGNNLATDIPNASVSHTGNAALHIDDLAYAVFTSGSTGAAKGVKVSHKNLVTAIHHHCKPERFQIGLNTRSLDSSSYSFDACIFNFFYTVTQGGCLCVPNDEALKGDIGAFMRQYKVNWAQLVPSVARTLNPKVLPDLKDLILTGEPLTRTDIETWCHNVRLFNVYGPTECTILCSISSPIKGSSHFGYIGRGQGANIWLTEIGNPDKLVPIGVPGEILIEGPIIGAGYLGPYQYPLVEDPPWLLAGTGHISGRQGKLFRTGDQALYTDDGTLVFIGRIGTDIKLRGQRVDIVAVEDIIRRHVPSGLEIAVGIARITVGGKVLAREMLLCFASQNQTFRDNGASPQNKLNDILRALVADIIPELDAAMPKYLHPEAFVALSSMPKTSSGKTDRRCLKEAEKQLRLHDLIWISTEMAESTNTPPSTQEEKVIAALWAEVIGIEHESISREDDFFKLGGDSLGVMRLTTKAHRLGLVLKSNDVFRNSKLASLAEKISWESIGPSEIAPYKPYSLVPEISDIDAFTANHIVPSLNIEANQVEDILPANGFQVDYIHNKEEPLGLRYAYLDIGPDVQWQRLIQACRTMLQGYECFRARFILYKGRYYQIILRDAPFIIEEISATQQIAIFSQQLCRADLHAASLSDVFSKMTLVNVGINRRRVILRLSHMQHDGWCTTQLLNAVAAAFNSLEIEKTPKWTSVLHYRHLMVEESCRYWRTKLQGATQITPSLVYKPGGSKVRTLRSYALSNFHASDDNRRTRPTVVVNVAWALILEQLAGHQDVVFGNVTTGRNGNMPGLDSVVGPCVNMLPMRLQLQSHSTTNREHKLRDLVEASAQQVDDGAFHNGLDWDELIDKCTTCVSGSRYKSAVHFRNMEFEPELSLGGDRVVVQWYELVETPRWTTVLVYPEENVLRLWLLADPAQIGDDGADEILHMLAGYCEEIVQSLQT
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the mycotoxin cyclochlorotine, a hepatotoxic and carcinogenic cyclic chlorinated pentapeptide (PubMed:26954535).  Cyclochlorotine is formed by the nonproteinogenic amino acids L-2-aminobutyrate (2Abu), L-beta-phenylalanine (beta-Phe), the unique L-cis-3,4-dichloroproline Pro(Cl(2)) and two L-serines (Ser) (PubMed:26954535).  The condensation of the 5 building blocks is performed by the cyclochlorotine synthetase cctN, a nonribosomal peptide synthetase (PubMed:26954535).  The assembled linear pentapeptide is then assumed to be released through cyclization by the terminal condensation-like domain of cctN (PubMed:26954535).  Incorporation of the alternative substrates allo-threonine or alanine by the domains A3 or A1 respectively may lead to the production of the variants hydroxy-cyclochlorotine and deoxy-cyclochlorotine, respectively (PubMed:26954535).  CctP probably acts as a phenylalanine aminomutase and provides the uncommon building block beta-Phe (PubMed:26954535).  Furthermore, 2Abu can be synthesized from threonine by one of the threonine dehydratases and transaminases localized outside of the cluster (PubMed:26954535).  The biosynthesis of the unusual dichloroproline moiety remains elusive since the actual halogenase still awaits to be detected, with the possibility that proline halogenation is accomplished by a so far unknown type of halogenase (PubMed:26954535).  Finally, the cluster encoded transporters cctQ and cctS are most likely responsible for cyclochlorotine secretion and thereby may contribute to intrinsic resistance (PubMed:26954535).  The functions of the remaining proteins encoded by the cluster (cctM, cctO, cctR and cctG) have not been identified yet (PubMed:26954535).
What are the official names of this protein?
Cyclochlorotine synthetase, Cyclochlorotine biosynthesis protein N, Nonribosomal peptide synthetase cctN, NRPS cctN.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.