PharMolix/UniProtQA huggingface dataset:
Protein: SKIT3_MOUSE
Sequence: MGSIQIIFAAYCVVLCVLQMLVLSSEQFTITGLERPVLAPLGGILELSCQLSPPQNAQQMEIRWFRNRYTEPVYLYRNGKDLHGETISKYVERTELLKHDIGKGKVTLRVFKVTVDDDGSYHCVFKDGIFYEEHITEVKVTATSSDIKIIMHPPNIKGVMLECHSRGWFPQPHMEWRDSNGQVIPATSKSQSQDENKLFNMTMNLFADVGLHQIVTCYIQNLLTHQEESISIVLTGDLFSWKIDWILILSIIACVMIPYSMTSYLQQHLIHGSCSQRSHHWRKNAMVCMSSVIAIIGSMLILHLKQRVPISDQHFELDTLYLEDISVILCVVIVFNLKLNLLTYYRLERKYDGCTPGCKACFYILKIIIIILPFVFTFGCYNAIFLKYHQLQKKVSIPDPLYYFYTSWLVNMEMLGVFLVFFPTFINLIEFSQFIKTVPKPIWLCQENMREDDAIRHR
What is the function of this protein?
May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus.
What are the official names of this protein?
Selection and upkeep of intraepithelial T-cells protein 3, Skint-3.
What is the protein family that this protein belongs to?
Belongs to the SKINT family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNJB8_MOUSE
Sequence: MANYYEVLGVQSSASPEDIKKAYRKLALRWHPDKNPDNKEEAEKKFKQVSEAYEVLSDSKKRSVYDRAGCDRWRAGGGANVPHSSPFGAGYPFRNPEDIFREFFGGLDPFSFEFWDTPFSGRGRPHGLHRVFPSGFGEFPAFMEALSSFNTLGHGGGSRSTFSSASFGGSGSSGFKSVMSSTEMVNGRKVTTKRIIENGQERVEVEEDGQLRSVTVNGKEKLMRVDK
What is the function of this protein?
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.
What are the official names of this protein?
DnaJ homolog subfamily B member 8, mDj6.
Protein: C7017_ORYSJ
Sequence: MEAFVSGGAGGVGAAAVVGVFVAAAVVGGFVAAVALAERAGVIAPRKRPNAPPAVPGLPIIGNLHQLKEKKPHQTFTKWAEIYGPIYTIRIGASSVVVLNSTEVAKEAMVAKFSSISTRKLSKALTVLTRDKSMVATSDYGDFHKMVKRYVMSSTLGTSAQKKFRDTRDMMINNMLSTFHKLVKDDPHVPLIFRDVFKDELFRLSMIQSLGEDVSSVYVDEFGRDISKEEIYNATVTDMMMCAIEVDWRDFFSYLSWVPNKSFETRVFTAEARRTAVMRALIKQQKERIVRGEVTKCIL
What are the official names of this protein?
Ent-kaurene oxidase-like protein 1, OsKOL1, Cytochrome P450 701A7.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS11_NANEQ
Sequence: MAKERWGVAHIYSSENNTIIHITDITGAETIAVGSGGMVVNADRLEGSPTAAILAAKRAAALAKERGITGLHIKVRAPGGHNGPWIPGPGASAAIKTLAREGLKIGIIEDVTPTPHDGCRRKGGKRGRRV
What is the function of this protein?
Located on the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: CH10_POLNA
Sequence: MNLRPLHDRVIVKRVENETKTASGIVIPDSAAEKPDQGEVLAVGPGKKNDKGELGAMAVKVGDRVLFGKYSGQTVKVDGDELLVMKEEDLFAVVEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CK086_MOUSE
Sequence: MGTSLRSQSFREPRPSYGRLHESQGRSLDGRLHRALSLRLGREKSRSQVPDGTEGLEVSVQERLPGTLGDKEQLIQGQRGGGSRRWLRQYQQHVKRRWRSFVASFPSVTLSQPASPETLLDTNN
What are the official names of this protein?
Uncharacterized protein C11orf86 homolog.
Protein: PSTB_TROW8
Sequence: MTSLLEIKDLTAFYGPLRAIKDVSLSIQEGSVTALIGPSGCGKSTLLRTLNRMHELSPGAKVKGQVLLDGRDLYQLDPVYVRQEVGMISQRPNPFPTMSIRENVLAGIKLNRKRIHRIQQNELMERCLRSVNLWDEVHNRLGRPGGELSGGQQQRLCIARAIAVSPRVILMDEPCSALDPVSTKAIEQLICKLKEKHTIVIVTHNMQQASRVSDWTAVFNVARSGGSGELVEHDKTEVIFTSPKNEVTLNYISGKFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: IF1_LACJO
Sequence: MAKEDVIEVEGKVVDTLPNAMFKVELENGATILAHVSGKIRMHYIRILPGDRVTVELSPYDLTKGRITYRFIK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_PROA2
Sequence: MKHSIDSLQKEIESFAITSNETLEEFKLTYLVRKGSIANLFKQLKDVSPDERRAVGQLLNTLKTTAEKKYEDAKDTLASSAASEKNNIIDLTLPGRTHFLGSEHPVQKVLGDMKQIFTAMGFAIETGPELECGVYNFDKLNFPPDHPARDMQDTFFIKLDEKDGNDVLLRTHTSPVQIRVMLDQRPPIRVICPGKVYRNEAISSRSYCVFHQLEGLYIDKNVSFADLKATIYSFAKQMFGQDVQLRFRPSFFPFTEPSAEVDVTCYLCNGKGCKVCKQSGWLEILGCGMVHPNVLCQCGIDPEEYSGYAFGMGVDRTALLRYKIDDIRLLFENDIRMLDQFMQ
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAH_BURP6
Sequence: MTNFSSSPPIAFGDLQGCHAAYRQLFDTLAPAADTPLWFAGDLVNRGPASLATLREIVALGERAIAVLGNHDLHLLAVAAGIRTLKPGDTIGEILDAPDADDLIEWVRHRPFAHFERGMLMVHAGLLPQWDAALALELADELQRALRAPNWRDTLRSLYGNDPNCWSPDLKHADRLRVAFNAFTRIRFCTPEGAMEFRANGGPAAAPAGYLPWFDAPGRKTADVTVVFGHWAALGLMLRENLVALDSGCVWGNRLSAVRLTDDPAARVVTQVACERCGAADE
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: MASOD_ORADR
Sequence: MKQTIVIVLLAAVAMMACLQMVAAEPLPEAAPAPSPLAEAEALASPIAEALANPEALASPEAGRILSFIKGLAEHLGKK
What is the function of this protein?
Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations.  Also exhibits strong antimicrobial activity against the fungi C. albicans and B. cinerea, and weaker activity against the Gram-negative bacterium E. coli and Gram-positive bacterium S. aureus.
What are the official names of this protein?
Eumenine mastoparan-OD, EMP-OD, Venom peptide 1, OdVP1, VP1.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Mastoparan subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL7A_CENSY
Sequence: MAKGYYVKFETPKDLVNPILEALRAATQSGKVKKGTNEATKAIERGTSKLVVIAEDVEPPEVVAHLPILCDEQGAAYAFVPSKQDLGKALGIDITSAAAILDSGDAQHIVDQVISSIAKIKGETGK
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_MARSD
Sequence: MRFIDQLDIAGKKLLMRVDFNVPLDGETITDDNRIKAAVPTFKYALEKGASVIVMAHLGKPKGKRVDSLSLAPAAKRLGEYLGMEVPLAPDCIGSEVEKMAAELKPGQVMMLENLRFHAEEQAKTPEERGDFGKQLAALADIYVNDAFGVAHRANASVVDVPYAAKECCAGFLLKLEWEYLGEALKNARKPYIAVSGGAKVSSKLGILNNLIGKVDDFIIGGAMANTFLLAQGKAVGKSLVEESLVDTAKEIMDKAASSGTTLHLPTDFIWGKDIETAQGVCDGDSVPEDGMLLDIGPESAKKFCEVIERSKTIVWNGPMGLFEKEPFAQGSLKVCEVMANLDDATTIVGGGDTDAVVHQAKLEDKFTFISTGGGSFLEFLEGKELPAFKALKENS
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOH_XANOM
Sequence: MHIDVIGHGPALVLLHGWALHGGVFAPLVERLAPHYQLHLVDLPGHGFSRDDSTPLALPYVVAEIAAATPPAVWLGWSLGGLFALHAAATLPQVRGLAMIAATPRFVRGSDWPDAVQRELFVQFGTELSRDYRGTLERFLALDTLGSAHARSELRSLRETLTARGEPAPEALQQGLSLLERTDLRRALPQLARPSLWIAGQRDRLVPAAGMHAAAALSPHAQALTIAGGGHAPFLGHADQVSEALQRFVASVP
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFI_NOSP7
Sequence: MKFYRDHTWPSTLEEAIVIQEKLRDQVITEDQLEEPIQYVAGVDMGFEADGTISRAAVAVLSFPDLQVIETSLAHRPTTFPYVPGFLSFREIPAVLDALEKIQTTPNIILCDGQGIAHPRRLGIASHLGLLIDMPTIGVAKSRLVGKYEELAETKGSSQPLIYNGETVGVVLRSRTGVKPLYISSGHRISLPTAIDYVLRCTPKYRLPETTRIADKLASAK
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_MYCS2
Sequence: MARRPDLQSGPERLAALVRSSIPPMHSAGLPFVGASLAVALLGRKRRWMRRAGLISAGANAAFFRHPPRVPPTRPGVVVAPADGLICLLGEATPPAELGLPDIPMQRVSIFLSVLDAHVQRAPIGGEVVAVRHRPGRFHSAELEAASEDNERNSVVIRTPEGLHIIAVQIAGLIARRIVCDVHVGDKLSIGDTYGLIRYGSRLDTYFPADARVLVSHGQRTLAGETVLAELA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: B3GN3_HUMAN
Sequence: MKYLRHRRPNATLILAIGAFTLLLFSLLVSPPTCKVQEQPPAIPEALAWPTPPTRPAPAPCHANTSMVTHPDFATQPQHVQNFLLYRHCRHFPLLQDVPPSKCAQPVFLLLVIKSSPSNYVRRELLRRTWGRERKVRGLQLRLLFLVGTASNPHEARKVNRLLELEAQTHGDILQWDFHDSFFNLTLKQVLFLQWQETRCANASFVLNGDDDVFAHTDNMVFYLQDHDPGRHLFVGQLIQNVGPIRAFWSKYYVPEVVTQNERYPPYCGGGGFLLSRFTAAALRRAAHVLDIFPIDDVFLGMCLELEGLKPASHSGIRTSGVRAPSQRLSSFDPCFYRDLLLVHRFLPYEMLLMWDALNQPNLTCGNQTQIY
What is the function of this protein?
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine.  Has activity for type 2 oligosaccharides (PubMed:11042166).  Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191).
What are the official names of this protein?
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3, Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase, Beta-1,3-galactosyltransferase 8, Beta-1,3-GalTase 8, Beta3Gal-T8, Beta3GalT8, b3Gal-T8, Beta-3-Gx-T8, Core 1 extending beta-1,3-N-acetylglucosaminyltransferase, Core1-beta3GlcNAcT, Transmembrane protein 3, UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, BGnT-3, Beta-1,3-Gn-T3, Beta-1,3-N-acetylglucosaminyltransferase 3, Beta3Gn-T3, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: LRC34_HUMAN
Sequence: MAAQPPRPVGERSMGSSREAARAPARSPAWASTQASTPGAALAVQRESPESGLQKHYSNLCMEKSQKINPFILHILQEVDEEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTQNQAIKAINLNRPILYSEQEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTYGESYDHSSNAGFALVPVGQQP
What is the function of this protein?
Highly expressed in stem cells where it may be involved in regulation of pluripotency.  In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4.  Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4.  Promotes stem cell proliferation in vitro.
What are the official names of this protein?
Leucine-rich repeat-containing protein 34.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=As stem cells differentiate, translocates from the nucleolus to the nucleus and then to the cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus.
Protein: Y598_BRUME
Sequence: MAQGDDNKQAIGQIIRQEQALIFPSLDENDAFSLGQRIRDIAVKDKLGIAIDISLWGRRLFFAATAGATADNTEWLRRKFNVVRRFHVSTYRLVLEQNREDRMFAPYKALDVADYALAGGGFPIRVSGAGVIGAVIVSGLPQREDHNLVVRAVAEHVGQDPVALALPAA
What are the official names of this protein?
UPF0303 protein BMEI0598.
What is the protein family that this protein belongs to?
Belongs to the UPF0303 family.
Protein: MEPM_SHIFL
Sequence: MQQIARSVALAFNNLPRPHRVMLGSLTVLTLAVAVWRPYVYHRDATPIVKTIELEQNEIRSLLPEASEPIDQAAQEDEAIPQDELDDKIAGEAGVHEYVVSTGDTLSSILNQYGIDMGDITQLAAADKELRNLKIGQQLSWTLTADGELQRLTWEVSRRETRTYDRTAANGFKMTSEMQQGEWVNNLLKGTVGGSFVASARNAGLTSAEVSAVIKAMQWQMDFRKLKKGDEFAVLMSREMLDGKREQSQLLGVRLRSEGKDYYAIRAEDGKFYDRNGTGLAKGFLRFPTAKQFRISSNFNPRRTNPVTGRVAPHRGVDFAMPQGTPVLSVGDGEVVVAKRSGAAGYYVAIRHGRSYTTRYMHLRKILVKPGQKVKRGDRIALSGNTGRSTGPHLHYEVWINQQAVNPLTAKLPRTEGLTGSDRREFLAQAKEIVPQLRFD
What is the function of this protein?
A murein DD-endopeptidase with specificity for D-Ala-meso-diaminopimelic acid (mDAP) cross-links.  Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion.  Functionally redundant with MepM and MepH (By similarity).
What are the official names of this protein?
Murein DD-endopeptidase MepM, Murein hydrolase MepM.
What is the protein family that this protein belongs to?
Belongs to the peptidase M23B family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HSLV_LACPL
Sequence: MTTKFEATTICAVRQNGHNAMAGDGQVTMGEKVVMKGTAHKVRRIYNDQVVVGFAGSVADAFNLEDRFEKKLNEFSGNLQRAAVELAQEWRSDQALQKLEALLIVMNKDDMLLVSGSGEVITPDNDVLAIGSGGNFALAAARAMQLHAKDMSAKEVAEAAIHIAGDIDIFTNHNVISETL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG33_ICHVA
Sequence: MEPISYVTITDYTAFANWLLSTTTVTDVRFWDRIGGFFNLTASNGRLLDLSRRAYVHWNLRVHGHFSELCTVGGGVERTPLFRALTLRAWNSEPERVLRTIRELRTEKLHERGDYWGRNLEYMCTNILAETPEPIFRTLCHTRIIPELKRLVTTWKVYITAMYAGRHDDLVLQVTYFIRRSIEVDRPLLEFIGELKHSCSLPISRKMTTDKTFHVSGFITTTCTKELDRDDTARLVHRNGTGFETVVDRIVWGATMWWYRRTYRAVESYDEFWYKYCGWMDTPTGELPDE
What are the official names of this protein?
Uncharacterized protein ORF33.
Protein: HBP1_HUMAN
Sequence: MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKNHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
What is the function of this protein?
Transcriptional repressor that binds to the promoter region of target genes.  Plays a role in the regulation of the cell cycle and of the Wnt pathway.  Binds preferentially to the sequence 5'-TTCATTCATTCA-3'.  Binding to the histone H1. 0 promoter is enhanced by interaction with RB1.  Disrupts the interaction between DNA and TCF4.
What are the official names of this protein?
HMG box-containing protein 1, HMG box transcription factor 1, High mobility group box transcription factor 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: SSRP_MYCLE
Sequence: MARNPRGGKQIVATNRKARHDYAIIELFEAGVALLGTEVKSLREGHASLADAFATVDSGEVWLRNMHIPEYQHGSWTNHDPRRNRKLLLHRRQIDTLVGKIRDGNLALVPLSLYFAEGKVKVELALARGKKLHDKRQDMARRDAQREVIRELGRRAKGML
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: DPMPE_MACPH
Sequence: MESSSSKGGFKVLIIGGSVTGLTLAHSLDKMGVDYRLLEKRKEIAPQEGASIGILPNGARILDQLGLYNAIEQSAIALGTSDVYFPDGFHFTSSYPKRMHDRRSFAYPIAFMERRKLLEILYDLLPDKSRVEVDKAVSRIEEHPEHHGVLRAYTHDGDVYEGNLVVGADGVHSRTRREMWRLSGSSPTGDVPVSERNSTSVEYACIFGISDGIAELTPGRQVMRFGNGWTLAVIPSRQGQVFWFIVQKLDREYQYGSAPRFAPEDAAEQCSKLARLPIHGDVRFDDLWQRRKAVNMAALEENVFQTWSCGRLVCIGDSIHKMTVNLGQGANCAIEDVAVLCNILHHALNEKANSELSDQDVEALLRRFHKEHFPRVSRVYDMSWSVTRVHARDGSMRKFVGRYVAPYFGERLQGRLFNLMADAAKIDFLPLPRASRSGWEEYRSSERNALLWASSLALLIVLIALFTGRSYW
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpmpA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpmpD through the action of the prenyltransferase dpmpC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpmpE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpmpB (Probable).  The short chain dehydrogenase/reductase dpmpG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpmpH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Higginsianin B is further methylated by the methyltransferase dpmpI to produce the intermediate named FDDP B (PubMed:32286350).  The cytochrome P450 monooxygenase dpmpJ then oxidizes the C-26 methyl to primary alcohol, producing the final diterpenoid pyrone with a C-26 primary alcohol on the gamma-pyrone moiety named FDDP C (PubMed:32286350).
What are the official names of this protein?
FAD-dependent monooxygenase dpmpE, Diterpenoid pyrone biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PGTA_HUMAN
Sequence: MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT
What is the function of this protein?
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
What are the official names of this protein?
Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type II subunit alpha, Rab geranyl-geranyltransferase subunit alpha, Rab GG transferase alpha, Rab GGTase alpha, Rab geranylgeranyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit alpha family.
Protein: ACKA_CAMJ8
Sequence: MKILVLNSGSSSIKFKFFDNKVVKASGLVEKIGEQNSKVILKNVLNNESFERELMINNHEEGLSIVNELFKESGILADLNALDGCGHRIVHGGRNLSEHCLVDDYVLKEIDRVSIFAPLHNPAHLAGIKTMIKAAPSVANVAIFDTAFHRTMPDFAYMYALPYDFYDKHNIRRYGFHGTSHAFVSSRAASLLEKDKSELNVISAHLGNGASVCAIEKGKSVDTSMGFTPLEGLVMGTRCGDLDPAILPFISHLKGLTIEEIDTLMNKKSGVYGICGYNDFRDIEREIEQGNDKARLALDMFCYRLVKYIGSYFAVLPKTDAIIFTGGIGENDSLVRQKVCERLAHLGIELDFELNKQRISGERMINHANSKVKVLVIPTDEELEIARITEELISN
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_BRUME
Sequence: MTQRLRIALIAHDQKKDDMVAFARAHEQALSRYDIVATGTTGGLIQDACPSLNIHRVKSGPLGGDQQIGAMIAEGTVEVLIFFIDPLSPLPHDVDVKALTRLGSVYDIPMALNRATAEKLVRALD
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: COAE_SALPA
Sequence: MRYTVALTGGIGSGKSTVADAFADLGITVIDADIIARQMVEPGQPALNAIAEHFGSELIAADGTLRRRALRERIFSHPEEKAWLNALLHPLIQQETQQQFQQATSPYVLWVVPLLVENRLYQKANRVLVVDVMPETQLIRTMQRDDVTREHVEHILAAQATREARLAVADDVIDNNGAPDAIASDVARLHASYLKLASQFVSQEKP
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.