PharMolix/UniProtQA huggingface dataset:
Protein: POLL2_ARATH
Sequence: MMVAVQLFTWKPLVLLPSQSSRLDRFASFNRSLSLKSLPLGGIGSFRCPGTFKVKSQRTGDTEPSSSVNLNDFSSILHKSLPYKVVIGCIPLYAVFRIAQKICQELPRLVQNSVGAGLPFACASNSLPTPLKLDVSFPSFQDIRWGLARFLYLFNIQLEKNIGTFLVALMIACVSFVIIGGLLFFKFRKDLPLEDCLWEAWACLISSSTHLKQKTRIERVIGFVLAIWGILFYSRLLSTMTEQFRYNMTKLREGAQMQVLEADHIIICGINSHLPFILKQLNSYHEHAVRLGTATARKQRLLLMSDTPRKQMDKLAEAYSKDFNHIDILTKSCSLNLTKSFERAAASMARAIIILPTKGDRYEVDTDAFLSVLALQPIQKMESIPTIVEVSSPNTYDLLKSISGLKVEPVENVTSKLFVQCSRQKDLIKIYRHLLNYSKNVFNLCSFPNLVGTKYRQLRLGFQEVVVCGLLRDGKVNFHPNDNEELMETDKLLFIAPLNWKKKQLLYTDMKLENITVPTDTRKQVFEKKRSRLSKIIMRPRKSLSKGSDSVKGPTESILLLGWRGDVVQMIEEFDNYLGPGSSMEILSDVSLEDRRRVGDSIGSVKIKNIQVSHKVGNPLNYDTLKQTIMRMKSKYRKGKNIPLTILVISDRDWLLGDPSRADKQSAYSLLLAESICNKLGVKVHNLASEIVDSKLGKQITGLKPSLTFIAAEEVMSLVTAQVAENSELNEVWKDILDADGDEIYVKDVELYMKEGENPSFTELSERAWLRREVAIGYIKGGKKMINPVPKNEPLSLEMDDSLIVISELEGDQPITL
What are the official names of this protein?
Putative ion channel POLLUX-like 2.
What is the protein family that this protein belongs to?
Belongs to the castor/pollux (TC 1.A.1.23) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL35_WOLTR
Sequence: MKLKTKSSVKKRFNLTAKGKVISAQSGKRHGMVKRSKSNIRNQRGTTVLGKSDSRIVKLYIPYGI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: JZ21A_CHIGU
Sequence: MKTSVLLVILGIAAITVQCTASESVEQDSLRTFVDAVLGWNAEMASEARCGGWMAKCADSDDCCETFHCTRFNVCGK
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U14-theraphotoxin-Cg1a 1, U14-TRTX-Cg1a, Jingzhaotoxin-21, JZTX-21, Peptide F3-11.69.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 65 (Jztx-21) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL10_HALMA
Sequence: MSAESERKTETIPEWKQEEVDAIVEMIESYESVGVVNIAGIPSRQLQDMRRDLHGTAELRVSRNTLLERALDDVDDGLEDLNGYITGQVGLIGTDDNPFSLFQELEASKTPAPIGAGEVAPNDIVIPEGDTGVDPGPFVGELQSVGADARIQEGSIQVLSDSTVLDTGEEVSQELSNVLNELGIEPKEVGLDLRAVFADGVLFEPEELELDIDEYRSDIQAAAGRAFNLSVNADYPTATTAPTMLQSARGNAKSLALQAAIEDPEVVPDLVSKADAQVRALASQIDDEEALPEELQGVEADVATEEPTDDQDDDTASEDDADADDAAEEADDDDDDDEDAGDALGAMF
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10, Acidic ribosomal protein P0 homolog, HMal10, L10E.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: PI42A_MOUSE
Sequence: MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYVIKTITSEDVAEMHNILKKYHQYIVECHGVTLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKIFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDSTHPIGTPPDSPGNTLNSSPPLAPGEFDPNIDVYAIKCHENAPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHIL
What is the function of this protein?
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).  Has both ATP- and GTP-dependent kinase activities.  May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity).  May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity).  Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (By similarity).  In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (PubMed:29727621).  Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:29727621).  Negatively regulates insulin signaling through a catalytic-independent mechanism.  PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity).  May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (PubMed:16434494).
What are the official names of this protein?
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, Phosphatidylinositol 5-Phosphate 4-Kinase, PI5P4Kalpha, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, PI(5)P 4-kinase type II alpha, PIP4KII-alpha, PtdIns(5)P-4-kinase isoform 2-alpha.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Lysosome. Cytoplasm. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (PubMed:20204506). Localization to the nucleus is modulated by the interaction with PIP4K2B (By similarity).
Protein: SLX1_CRYNJ
Sequence: MSDDAEVTNNKKTTKSTLLDGNHIFPPFYACYLLRSKATANSNRTYVGSTPDPPRRIRQHNGELKQGAWSTSRHRPWEMQMIVYGFPSKLAALQFEWAWQKPELSRHLRIRGEDQEYYHIFTKDARRNWVERKVCVAYALISLTPFNRLPLHVRFFNHETHGIWQSIHEQAGVNTIQRGKSRAKPVNPLHLLSQSVAPAVTIILDLGGVSGTSGKRRECTKGVMSHEGPIDVKDVEFRQGFGVRGKWLEIRKRILSGQDLCCHLCQERIAFNDHLTFSICPLAESQDCFCITHLICLAKHFQDEAPVEDRRAPSQPKILPYQGLCPNCKRTVQWGQHIRACYARKEQVEKAEKAEKAEKAEKAEKAEKAEKAEKAEKAEKAGRKVRQREMKTKKGDQSNGTVAQPESIYSATPVHTTFGLSNASATLIDPSMPARSMKSKDVGGEGIRHSTHTDDSDGIISVYSETEDESESEPEWEIFEAEMMALS
What is the function of this protein?
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1920_LEGPH
Sequence: MDKKLLEILVCPLCKGKLLFKKQELICKFDRLAFPVRDDIPVMLEQEARLIPLEEKDKL
What are the official names of this protein?
UPF0434 protein lpg1920.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: ACUK_COCP7
Sequence: MTANAINGPVLPTPLATPGDNNKSADTTMADQGTRPESQPQGQNNGAKPQNGQTKPMSAANAKDPLRPRRKKAKRACFACQRAHLTCGDERPCQRCIKRGIQNACHDGVRKKAKYLHDAPNEALMPHLQGHLYTTQANTARNTIPLTRNGSNSKTNFYPQQQSSFNNFYQNKPDPTLNQPQLHDTGRPDTFPSQSPVSPTFNMTANPAASGNQGLPSSLSASNSNASGQAQNGFGSAFFDPSDPALFNFDLASMNFGNHYGALEFGMLGHMATGAGETPPSDGATQHGSVGRSGSGTYTAGSNFGESPTGQPSFLFGDPTIGGDWTSSVNTRNIYGQNMNNMSETPHAFAIESAPANFASPNSIESPLLTNTTTFDDNTAPTYANRANINSVPSQRQPVVSTPQLKHLQVGKRRQRNPSAIYDSVKEPYSYTTGFHSLTAFIQRRFSPQNTLRIAKALASIRPSFIATTKTLNRDDLIFMEKCFQRTLWEYEDFINACGTPTIVCRRTGEIAAVGKEFSILTGWKKEVLLGKEPNLNINTGGSSGAMSGVTSRGSFTPRTGMDINPTGRTQPVFLAELLDDESVVEFYEDFAKLAFGDSRGSVMTTCKLLKYKTKADMDMLSGTTSSAGGENEHGAAGNGDVKPENGMGASNGQSQHSLQRQRKWSRGGIAGEAGMNQLGFKDGKVECSYCWTVKRDVFDIPMLIVMNFLPCI
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization.  Activator of gluconeogenetic genes (By similarity).
What are the official names of this protein?
Transcription activator of gluconeogenesis CPC735_053490.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FER_HUMAN
Sequence: MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
What is the function of this protein?
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis.  Acts downstream of EGFR, KIT, PDGFRA and PDGFRB.  Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation.  May play a role in the regulation of the mitotic cell cycle.  Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.  Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.  Plays a role in the regulation of mast cell degranulation.  Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS).  Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission.  Plays a role in neuronal cell death after brain damage.  Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11.  May phosphorylate JUP and PTPN1.  Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
What are the official names of this protein?
Tyrosine-protein kinase Fer, Feline encephalitis virus-related kinase FER, Fujinami poultry sarcoma/Feline sarcoma-related protein Fer, Proto-oncogene c-Fer, Tyrosine kinase 3, p94-Fer.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
Protein: ANMK_BURO1
Sequence: MPQRQPQPAHPVDGIYFGLMSGTSMDGVDGVAVRFEAGRAPVVLAEAFVGFAQSLRDALFALQQPGDNEIDRESLAANALVARYAVCCHELQRTAGLSRDEIRAIGVHGQTVRHRPERGYTRQLNNPALLAELTQVDVIADFRSRDVAAGGHGAPLAPAFHATVFGAPGETRVVCNLGGISNITILPGADGDVRGFDCGPANALIDAWATRHLGKPYDDGGKFAARGTVQASLLGALLDEPYFTAPPPKSTGRDLFNPAWLDARLAAFPQVAPEDVQATLTALTAVSVAREIAQHAPGCKAVFVCGGGARNPVLLDALRHALREAGVPATVDTTAALGVPPQQVEALAFAWLAYRFTARQPGNLATVTGAAGNRVLGALYPR
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: EZHIP_HUMAN
Sequence: MATQSDMEKEQKHQQDEGQGGLNNETALASGDACGTGNQDPAASVTTVSSQASPSGGAALSSSTAGSSAAAATSAAIFITDEASGLPIIAAVLTERHSDRQDCRSPHEVFGCVVPEGGSQAAVGPQKATGHADEHLAQTKSPGNSRRRKQPCRNQAAPAQKPPGRRLFPEPLPPSSPGFRPSSYPCSGASTSSQATQPGPALLSHASEARPATRSRITLVASALRRRASGPGPVIRGCTAQPGPAFPHRATHLDPARLSPESAPGPARRGRASVPGPARRGCDSAPGPARRGRDSAPVSAPRGRDSAPGSARRGRDSAPGPALRVRTARSDAGHRSTSTTPGTGLRSRSTQQRSALLSRRSLSGSADENPSCGTGSERLAFQSRSGSPDPEVPSRASPPVWHAVRMRASSPSPPGRFFLPIPQQWDESSSSSYASNSSSPSRSPGLSPSSPSPEFLGLRSISTPSPESLRYALMPEFYALSPVPPEEQAEIESTAHPATPPEP
What is the function of this protein?
Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:31086175, PubMed:31451685, PubMed:30923826).  Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826).  Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity).
What are the official names of this protein?
EZH inhibitory protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: METK_PORG3
Sequence: MSYLFTSESVSEGHPDKVSDQISDAILDQFLATDPDSKVACETLVTTGQVVLAGEVKSRSYVDVQETARRVIEKIGYTKSEYGFDARSCGIFSSIHGQSADINRGVDRSDRSEQGAGDQGMMFGYATNETENYMPLTVDLAHHLLYELATIRKEPSSPMPYLRPDAKSQVTIEHDDEGRPVRIDTIVISTQHDEFVQASDGISEAEADRMMQERIHHDIATILIPRVKMLYKPEIAALFDEKVRLFVNPTGKFVIGGPHGDTGLTGRKIIVDTYGGRASHGGGAFSGKDPSKVDRSAAYAARHIAKNMVAAGVADEMLVQVAYAIGVAEPVSIYVNTKGRSHVALSDGQIAEKIKKIFDMRPYAIEQRLKLRNPIYEETAAYGHFGREPYEAYKTFVDEHGTEQMRIVELFTWEKLDYVNKIKAEFGLS
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_COXBR
Sequence: MTHSVQLKILDKRLGSEFPLPAYATTGSAGLDLRACLDEPLKIEPDETCLISTGLAIYLGHSNVAATILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRGKEPYTINPGDRIAQLVVLPILKAQFAVVEEFELTERGAGGFGSSGQN
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: NU3M_BALPH
Sequence: MNLLLTLLTNTTLALLLVFIAFWLPQLNVYAEKTSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQSNNLNTMLTMALFLISLLAASLAYEWTQEGLEWAE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MNMC_CUPMC
Sequence: MTRVLEPAEPILSNDGTPYSPRYDDVYHSARGGLAQAHHVFLGGNGLPEGWAGREQFVIVETGFGQGLNFLATWQAWRSDPQRCRRLHFVSIEKHPFTREGLARLHAHAGLGDLLPLSDQLQQQWPDALPGLHRLSFEDGAVTLTLALGDVETMLPKLVLGADAFYLDGFSPSRNAEMWSDTVFRGLARLARIGATLATYTAAGFVRRGLTAAGFEAHKAPGFGGKRDMTVARFAPVWKNRRHAPPEAAQWAERHAIVIGAGLAGCAVTERLAARGWRVTLLDAHDGPARQTSCHRAAAMHAHVSADDSFLSRLSRAGNLHALRAWGALEAAGYPVGWHGTGVLQIGEDDAENAAQQAALAELRFPESFVRWMSPQEATEQHGATVPRGGLWFPKGGWVAPPDICRAQLAKAGAAVDALFNCRVAAIRRIGDAWQALADDGGVLAAAPVLVLANAYEADRLTSGQFLALRRVRGQLTDLAPAQAEALGGWPDCVVTGGGYLLPRDAAGGARMGSSYEADEGPLVERPEVHAANLDRLASMLPDRASQIAQIDPATLQGYVGVRTVTYNRLPLVGRIADDAQALSRAAALRGAHLRDLPRLPGLYAALAYASRGLTWAALCAELIASQIEGEPLPLEADLADAIDPARLLLRALRHGHAQAPESAGPGVDAAG
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENKUR_BOVIN
Sequence: MVAMDPTGPSESIYNLIPSDWKEPPQPPRYVSIFKATVKDDMQKFKTAMKTMGPAKLEVPSPKDFLKKHSKEKILPPKKKFEWNERRKPPVPLRTDHPVMGIQSEKNFINTNAADVIMGVAKKPKPIYVDKRTGDKHDLETSGLVPKYINKKDYGVTPEYICKRNEEVKKAQEEYDNYIQENLRKAAMKRLSDEEREAVLQGLKKNWEEVHKEFQSLSVFIDSIPKKIRKQKLEEEMKQLEHDIGVLEKHKVIYIANKK
What is the function of this protein?
Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.  Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025).
What are the official names of this protein?
Enkurin.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Note=Sperm acrosomal crescent and flagellar principal piece.
Protein: ARND_PSE14
Sequence: MQAGLRIDVDTYRGTREGVPRLLDILDEAQVKATFFFSVGPDNMGRHLWRLARPTFFWKMLRSRAASLYGWDILLAGTAWPGKPIGRDLGPLMRRALDAGHEVGLHAWDHHGWQANAGRWNDRQLTAQIHRGVDCLSDILGNPVICSAAAGWRADQHVVQAKQAFGFRYNSDSRGATLFRPLLADGRLGTPQIPVDLPTFDEVVGPQLQPGAFNEYILNRFAAQRLNVYTIHAEVEGIVMADGFRQLLRQADAREIEFNPLGQLLPESIEQLPCGQVVRGHLPGREGWLGVQQ
What is the function of this protein?
Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
Protein: OR3A2_PANTR
Sequence: MEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLFLFAYLVTIGGNLSILAAILVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLSQLFFFHLLAGMDCFLLTAMAYDRFLAICWPLTYSTRMSQTVQRMLVAASWACAFTNALTHTVAMSTLNFCGPNEVNHFYCDLPQLFQLSCSSTQLNELLLFAVGFIMAGTPLVLIITSYSHVAAAVLRIRSVEGWKKAFSTCGSHLTVVCLFFGTGIFNYMRLGSEEASDKDKGVGVFNTVINPMLNPLIYSLRNPDVQGALWRIFLGRRSLT
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 3A2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MENG_BACCQ
Sequence: MQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRKETMRIMDVKPGSKALDVCCGTADWTIALAGAVGEQGKVVGLDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYVTIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKLFAKSYKEYSWLQESASTFPGMKELANMFEKAGLERVQVKPFTFGVAAMHLGMKPESK
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
What are the official names of this protein?
Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RL16_SYMTH
Sequence: MLAPKRVKWRRVHKAVAKLNKGRSKAGNEVVFGDYGLQALEPAFITDRQIEAARVAMTRFIKRGGKVWIKIFPHKALTRKPAEVRMGSGKGAPEVWVAVVKPGRILFELAGVDEETAQEAMRLAAHKLPIKCKFVKREKAVTPAAAETGGEANEG
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: HBB1_ONCMY
Sequence: VEWTDAEKSTISAVWGKVNIDEIGPLALARVLIVYPWTQRYFGSFGNVSTPAAIMGNPKVAAHGKVVCGALDKAVKNMGNILATYKSLSETHANKLFVDPDNFRVLADVLTIVIAAKFGASFTPEIQATWQKFMKVVVAAMGSRYF
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain, Hemoglobin beta-I chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PURA_STRPC
Sequence: MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIFFPQKISVIGNGVVVNPKSLVKELAYLHDEGVTTDNLRISDRAHVILPYHIQLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFAERLRINLAEKNRLFEKMYDSTPLGFDAIFEEYYAYGQEIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLDTVKICVAYDLDGKRIDYYPASLEQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRVGELVGVRISTFSVGPGREQTNILESVWASI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERG20_ASPFU
Sequence: MATTTSRAAFEAVFPTLAEDLLAHAKKYNLPENAVKWFEQVLNVNVPGGKLNRGLSVPDTGIALLQKPLTDEQFKHLSILGWLTELLQAFFLVSDDMMDSSITRRGQPCWYRHPGVGLIAINDAFMLESGIYVILKKHFRSHPAYVDFLELFHETTWQTELGQLCDLITAPEDKVDLDNFSMEKYMFIVTYKTAYYSFYLPVALALLYLELATPENLQQTHDILIPLGQYFQVQDDYLDAYGDPAVIGKIGTDIQDNKCSWLINQALQRCNTEQRKLLDTAYGRKDSELEAKVKALYKELDLEKVYKEYEEKTVGEIRRKIAAIDESQGLKKEVFEAFLGKIYKRTK
What is the function of this protein?
Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity).  Erg20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).  The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.  Activity by the mevalonate kinase erg12 (AFUA_4G07780) first converts mevalonate into 5-phosphomevalonate.  5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase erg8 (AFUA_5G10680).  The diphosphomevalonate decarboxylase mvd1 (AFUA_4G07130) then produces isopentenyl diphosphate.  The isopentenyl-diphosphate delta-isomerase idi1 (AFUA_6G11160) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).  Finally the farnesyl diphosphate synthase erg20 (AFUA_5G02450) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:16110826, PubMed:22106303) (Probable).
What are the official names of this protein?
Farnesyl pyrophosphate synthase erg20, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase erg20, Dimethylallyltranstransferase erg20, Ergosterol biosynthesis protein 20, Farnesyl diphosphate synthase erg20, Geranyltranstransferase erg20.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.