PharMolix/UniProtQA huggingface dataset:
Protein: QSER1_MOUSE
Sequence: MDAHYAPAGFAEPPAPPASAATQPAAPAWAYEARVPAAASSPSCSGSSPSLKASYEDGHPSQSESDVLQRQTFTASHQLPGYATTPQATGMHSSAATELFVAGPLPTTGTLPPPTLSAYQHSSTFSNRNFATTSPLVLQDSSFNTTSNGILSPHDPLLQIKTSQGTVPTALAFERLGSSALSNSVPPQSSTYRSAQESAPHLLQPQFSLLPSTLGGAQQTPQAYNSALFPSSAASIERALLRECSVIKHHQRPSVTQSIQAQLTGSQHPLHSYLSSASIGNFQEPSRQSSLSCSSVRDSTQVSNGVLPQKTPQVSAELAQSYSSVIPSSGYLPSATKVDSCSTKQPLTSTTIPKPQSVIPPVQTLNYSKPLHNQSSVISGQAQIYSTAQLPSLLSVSQSQNYGLVQPHNVPSIVHSQVYRSSRVEKLPSLYKTLTFSGSSQPVTSENQTLSYSSNQQEVLSLVTNENYPAQTRDLPSVSESQNYSSGQSQGLSPVSQTQVSYSSQSQVLSVVSPSESYASGQSLTLTAPSLSYSSASRGQSLPVSTPTPSYTSMHPSPNAQTQGSSAQPQEFLPAVQSSFASSTRGQTLQSSIPSPDPKSYAERKLDSSVYTSSKQDEFPVQKLQALQSQASLESSSQRLPDGEVNAQESVYKTSKADDRYSQSVTRNNSHLEDQVVGVALQGSEQEENMVGSMTQLNQQSGQSNNAVATDLKKATNLMQTPQVRLNTKDLNQQHSLMHKMHEAKVQQQHDQIMSASSQIQIPNPALGQSHQALPHTSVLLDSACDLQILQQAGILQASLGQAKASLQVQRVQSPQQIVHPFLQMDGHIIQSNGEHPQQQLHPHNSDIMKLDLPEPSKPLQQLTTKGPFSEANPHDSKNQFVSLGSICFSEAMLLSDERNILSNVDDILAATAAACGVTPSDFSKSAANETMQDIESSDSKSHYQQSLNVRHVNSDFNSIAASVGKPQSINDISLNGNQVSVSLSSVPTLQSETVLDQPHMETPSQTIPTKVPSAMVGLGQEIQEQSSDPFKKQLTINHESKEDREIAVDSALSNNRNQEFVSNSRSISGDSVVSERDFTLVGDDTGVLVNPRRSTLALLAMPQPGDAASGKTEDEKQDVTYFNLPKEKAKGKEQGKEEEDNQKQLKRSAQCKRQNPRGTDVYVPYTSPSLESCDEGFQHQEKMRQKIKEVEEKQPEVKTGFIASFLDFLKCGPKQQFSTLAVRVPNRTRRSGIQTTRTFCPPPFAKTSPAAQAPSETGGVSLSEKVDSELKTLEQLSSFSSDEEDPGSCGHDIYKNTSAPLTVLDATSDKTKKTVLEALPVATPGASAETAGVAPTASTAVATIKQDLHLTSLTVNTMENANSTESPTAIELDSLPSDQLAKGQDTVAIEGFTDEENIESGGEGQYRERDEFVVKIEDIETFKEALNTGKEPPAIWKVQKALLQKFVPEIRDGQREFAATNSYLGYFGDAKTKYKRIYVKFIENANKKEYVRVCSKKPRNKPSQTIRNIPSKPSSISKTSDPPVSKTTTTKTPSTKPKAKQLKIKAEPPPKKRKKWKEEFSSSQSESSPEVRSSSSEDEGFEPPAPSVTRFLNTRAMKETFKSYMELLVSIALDPDTMQALEKSNDELLLPHMKKIDGMLNDNRKRLLVNLHLDQPFKNALESFPELTVITRDSKAKSGGSAISKIKMNGKAYNKKTLRTSKTTTKSAQEFAVDPEKIQLYSLYHSLHHYKYHVYLICKNEISSVQKKNEDLGQEEIVQLCMKNVKWVEDLFEKFGELLNHVQQKCS
What is the function of this protein?
Plays an essential role in the protection and maintenance of transcriptional and developmental programs.  Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers.  Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation.
What are the official names of this protein?
Glutamine and serine-rich protein 1.
What are the subcellular locations of this protein?
Chromosome.
Protein: O16L6_CONST
Sequence: MKLTCVVIIAVLLLTACQLITADDSRGVQKHRSLRSTTKVSKSTSCMEAGSYCGSTTRICCGYCAYFGKKCIDYPSN
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-conotoxin-like 6.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CRCB_PSEA7
Sequence: MWKSILAIALGAALGALLRWFLGLKLNSLLPSIPPGTLLANLVGGYAIGAAIAYFAQAPGIAPEWRLLIITGFCGGLTTFSTFSAEVVTLLQEGRLGWAAGAIATHVGGSLLMTLLGLFSMNWMLGR
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: C71B1_TANPA
Sequence: MFSSFETLILSFVSLFFMMIFIHSKWISSYSKMAKNLPPSPFGLPIIGNLHQLGMTPYNSLRTLAHKYGSLMLIHLGSVPVIVASSAEAAQEIMKTHDQIFSTRPKMNIASIVSFDAKIVAFSPYGEHWRQSKSVYLLNLLSTKRVQSFRHVREDETNLMLDVIENSCGSEIDLSNMIMSLTNDVVCRIAYGRKYYEDWFKELMKEVMDVLGVFSVGNYVPSLSWIDRLSGLEGRAYKAAKQLDAFLEGVVKQHETKSNESMRDQDVVDILLETQREQASAGTPFHRDTLKALMQEMFIAGTDTTSTAIEWEISEVIKHPRVMKKLQQELDEIAQGRQRITEEDLEDTQHPYLEAILKESMRLHIPVPLLLPREATHDVKVMGYDIAAGTQVLINAWMIARDPTIWEDADEFKPERFLDTNIDYKGLNFELLPFGAGRRGCPGIQFAMSVNKLALANLVYKFDFKLPNGLRLEQLDMTDSTGITVRRKYPLLVIPTARF
What is the function of this protein?
Involved in the biosynthesis of germacrene-derived sesquiterpene lactones (PubMed:30468448).  Component of the parthenolide biosynthetic pathway; parthenolide and conjugates are promising anti-cancer drugs highly active against colon cancer cells (PubMed:30468448).  Catalyzes the conversion of costunolide and parthenolide to 3-beta-hydroxycostunolide and 3-beta-hydroxyparthenolide, respectively (PubMed:24704560).
What are the official names of this protein?
3-beta-hydroxylase, Tp8878, Cytochrome P450 71CB1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: T3JAM_HUMAN
Sequence: MISPDPRPSPGLARWAESYEAKCERRQEIRESRRCRPNVTTCRQVGKTLRIQQREQLQRARLQQFFRRRNLELEEKGKAQHPQAREQGPSRRPGQVTVLKEPLSCARRISSPREQVTGTSSEVFPAQHPPPSGICRDLSDHLSSQAGGLPPQDTPIKKPPKHHRGTQTKAEGPTIKNDASQQTNYGVAVLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSWKGQLNEDKLKGKLRSLENQLYTCTQKYSPWGMKKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQGLLQNQSLQLQEQEKLLTKKDQALPVWSPKSFPNEVEPEGTGKEKDWDLRDQLQKKTLQLQAKEKECRELHSELDNLSDEYLSCLRKLQHCREELNQSQQLPPRRQCGRWLPVLMVVIAAALAVFLANKDNLMI
What is the function of this protein?
Adapter protein that plays essential roles in both innate and adaptive immunity.  Plays a crucial role in the regulation of thymocyte development (PubMed:26195727).  Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727).  Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741).  Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680).  In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091).  However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851).
What are the official names of this protein?
TRAF3-interacting JNK-activating modulator, TRAF3-interacting protein 3.
What are the subcellular locations of this protein?
Cell membrane. Golgi apparatus membrane; Single-pass type IV membrane protein. Lysosome membrane. Mitochondrion outer membrane. Note=Accumulates on the mitochondria after virus infection.
Protein: ATP6_VIBCH
Sequence: MAAPGEALTPSSYITHHLTNLSTYKLGLVAEESSFWNVHIDSLFFSVLTGLIFLGVFRAVARKATAGVPGKLQCAVEMVVEFVDKNVKDTFHGRNPLIAPLALTIFCWVFLMNLMDLVPIDFLPYPAQHWLGIPYLKVVPSADVNITMAMALGVFALMIYYSIKVKGLGGFAKELALHPFNHWIMIPFNLLIEVVSLLAKPLSLGMRLFGNMFAGEVVFILCAAMLPWYLQWMGSLPWAIFHILVILIQSFVFMMLTIVYMSMAHEDNDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FPG_BURP6
Sequence: MPELPEVEVTRRGIEPFVAGRRVERVDVRTAMLRWPVPAGFAEMLRSREVLRVERRGKYLLFEVDAGWFIVHLGMTGTLRVLPNDAPPPAPAKHDHVDWIFDEFVLRFRDPRRFGAVLWHPRDAGDVHAHPLLASLGVEPFSAAFSGALLFGRTRGRTVSVKQALLAGDIVVGVGNIYASESLFRAGIRPTTAAGRVSLPRYERLADAVRATLADAIERGGSTLRDFVGSNGESGYFQLDCFVYDRAGEPCRVCGAPIRQIVQGQRSTYFCPNCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: IOVO_COSCO
Sequence: VATVDCSGYPKPACTMEYMPLCGSDNKTYGNKCNFCNAVVDSNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: S2540_DANRE
Sequence: MSCQESSPGPPGDITPFQQMMASCSGAIITSLLVTPLDVVKIRLQAQKNPFPKGKCFVYCNGLMDHICVCENGNTKVWYKAPGHFSGTLDAFLKIIRMEGIRSLWSGLPPTLIMAVPATVIYFTCYDQLFALLKLKMGDRSDLAPLFAGAIARVGSATVISPLELIRTKMQSEKQSYREMSAVIRSALKNEGLRSLWRGWGPTLLRDVPFSAMYWFNYEKGKWWLCKRYSCSEPTVAITFTAGALSGSIASIITLPFDVVKTKRQVEMGELQTMKLSTQVSSSTCSVMKRIVAENGVSGLFAGFMPRLIKVAPACAIMISTYEFGKAFFRKYNHQKEGQATASQHIISHTEKH
What is the function of this protein?
Probable mitochondrial transporter required for glutathione import into mitochondria.  Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity).  Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters (By similarity).
What are the official names of this protein?
Probable mitochondrial glutathione transporter SLC25A40, Solute carrier family 25 member 40.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ABA3_BOTFU
Sequence: MQQVITQTLVDDRFIQISDSKKSEGLATDSTKRQSQEQPIHDKDPIKAATAAMATTPLVKEHQDTWYYPPDIANDLQSINLPAELKGEIFACAWEYTRCVIPNYTNWNRYVAFMRIIIMGIIAEFRGEMVDVTASNNLLGYDLDATLAALFEGTPGHKEMAREYKTFLLITADKASERRDGELFRRYVNALAQSPRHWFRMRDCDALARFTIASALACNDLDDIWFTEDQFEILTEIGDTLYDAVAFYKHRAEGETNSTFAYMPEDLRIKAYSECREILWALDAAWARNPKLANVINFVRFFGGPIHMMMRRYRFVEENLTIGKSETDKVVDQTRKNFKLWNRVDANKRSVLNTQRYKALIARSEELMFPGLAEFLEMGGDGICDKCKYRESTVQNCHTSLVVLNYAANADYRGEST
What is the function of this protein?
Alpha-ionylideneethane synthase; part of the gene cluster that mediates the biosynthesis of abscisic acid (ABA), a phytohormone that acts antagonistically toward salicylic acid (SA), jasmonic acid (JA) and ethylene (ETH) signaling, to impede plant defense responses (PubMed:15240257, PubMed:16820452).  The first step of the pathway catalyzes the reaction from farnesyl diphosphate to alpha-ionylideneethane performed by the alpha-ionylideneethane synthase aba3 via a three-step reaction mechanism involving 2 neutral intermediates, beta-farnesene and allofarnesene (PubMed:30226766).  The cytochrome P450 monooxygenase aba1 might then be involved in the conversion of alpha-ionylideneethane to alpha-ionylideneacetic acid (Probable).  Alpha-ionylideneacetic acid is further converted to abscisic acid in 2 steps involving the cytochrome P450 monooxygenase aba2 and the short-chain dehydrogenase/reductase aba4, via the intermediates 1'-deoxy-ABA or 1',4'-trans-diol-ABA, depending on the order of action of these 2 enzymes (Probable).  Aba2 is responsible for the hydroxylation of carbon atom C-1' and aba4 might be involved in the oxidation of the C-4' carbon atom (PubMed:16820452).
What are the official names of this protein?
Alpha-ionylideneethane synthase aba3, Abscisic acid biosynthesis cluster protein 3, Sesquiterpene synthase aba3.
What is the protein family that this protein belongs to?
Belongs to the alpha-ionylideneethane synthase family.
Protein: RL29_ERYLH
Sequence: MAKVEDLRQKSDDQLAEELVQLKKEQFNLRFQAATNQLEAPARIREVRRSIAQIKTLQNERAASAAKA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: RUVB_BRUA1
Sequence: MSDRNPLIDADRRADEDNTLRPQTLDDFVGQAAARANLKVFIEAAKVRGEALDHVLFVGPPGLGKTTLAQIMAKELGVNFRSTSGPVIAKAGDLAALLTNLEERDVLFIDEIHRLSPAVEEILYPAMEDFQLDLIIGEGPAARSVKIDLAKFTLVAATTRLGLLTTPLRDRFGIPVRLNFYTVEELEYIVRRGARIMQMGISSDGAREVARRSRGTPRIAGRLLRRVRDFALVAGADIIDRRIADEALSRLEVDNRGLDQLDRRYLNIIARNFGGGPVGIETIAAGLSEPRDAIEDIIEPYLIQQGFLQRTPRGRVLTAVAWQHLGLPAPAEIIQQSQYGLFMEDE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RS3_CAUSK
Sequence: MGQKVNPVGLRLGINRTWDSRWFADGEQYGKLLHQDLAVRAMLKKRLYQAGVSRIIIERPHKKCRVTIYAARPGVIIGKKGADIDKLRKDLSVMTEGEVHLNIVEIRKPETDAQLVAESIAQQLERRIAFRRAMKRSIQSAVRLGAKGIRINVSGRLGGAEIARMEWYREGRVPLHTLRADIDYGFAEAKTTYGIIGVKTWIFKGEVLEHDPMALDKRLATESGPAGEGGGRERGDRPDRGDRGRRDRG
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CORA_THEMA
Sequence: MEEKRLSAKKGLPPGTLVYTGKYREDFEIEVMNYSIEEFREFKTTDVESVLPFRDSSTPTWINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL
What is the function of this protein?
Mediates influx of magnesium ions (PubMed:18276588, PubMed:22722933, PubMed:23781956, PubMed:23112165).  Mediates Co(2+) uptake (PubMed:21454699, PubMed:23091000, PubMed:23425532).  Has high selectivity for Co(2+) (PubMed:21454699, PubMed:23425532).  Alternates between open and closed states.  Activated by low cytoplasmic Mg(2+) levels.  Inactive when cytoplasmic Mg(2+) levels are high (PubMed:23112165, PubMed:23425532, PubMed:26871634).
What are the official names of this protein?
Cobalt/magnesium transport protein CorA.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRMB_STAAT
Sequence: MRVRYKPWAEDYLKDHPELVDMDGQHAGKMTEWFDKTQPIHIEIGSGMGQFITTLAAQNPHINYISMEREKSIVYKVLDKVKEMGLTNLKIICNDAIELNEYFKDGEVSRIYLNFSDPWPKNRHAKRRLTYHTFLALYQQILNDEGDLHFKTDNRGLFAYSLESMSQFGMYFTKINLNLHQEDDGSNILTEYEKKFSDKGSRIYRMEAKFHSQK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: CPFC_STRPJ
Sequence: MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVALVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQDSFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFVPISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNILAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGKLPKE
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXZ_RICPR
Sequence: MSKKSNKNLAFSLLGLMMSMVLLSFASVPIYNLFCKVTGYGGTTIKETVSVYSKVKGTKAIIIEFDANVDPNLPWHFIPRQKRVQIVPGQNTLVFYEAENLSNKDIIGTSIYNVTPNKAGKYFVKIHCFCFEEQLLKAREKVLMPVTFYIDNDFERDPEMENIKVITLSYSFFKIREL
What is the function of this protein?
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
What are the official names of this protein?
Cytochrome c oxidase assembly protein CtaG.
What is the protein family that this protein belongs to?
Belongs to the COX11/CtaG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: RL23_NATPD
Sequence: MTIKHPLVTEKAMNDMDFENKLQFVCHPEATKGDIAAAVESQFDVEVDSINTQVRMDGDKKAIVELSADDDAQEVASRIGVF
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PELO_NATPD
Sequence: MRIVDRESAEGRRERITLVPETLDDLWHLTYVLEPGDLVAGDTTRRIQRDDDKMRDTGGEREPMWIRIDVNNVEFAKFANRLRVGGDIVDCSREDQLGFHHTFNVEEHDELTVEKVWQVDQLERLEEAVEAAEQPDVAIATVEEGQAHIHTVAQYGVEERASITGTTGKGEYARSRDELFEELAAILRRLDAEAIILAGPGFTKQDALEHIEDNAPEAAEKIQVVDTASVGDRGVHEVLKRGAVDRIQTETRVSKEAELIDELMERIGEGEKAAYGVDEVAEAAEFGAIETLLILDERLREERAGEGDWAVDVNDIIENVEQQGGEVVVFSHEFDPGQQLANLGGIAALLRYRLS
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP2_POVM3
Sequence: MGAALTILVDLIEGLAEVSTLTGLSAEAILSGEALAALDGEITALTLEGVMSSETALATMGISEEVYGFVSTVPVFVNRTAGAIWLMQTVQGASTISLGIQRYLHNEEVPTVNRNMALIPWRDPALLDIYFPGVNQFAHALNVVHDWGHGLLHSVGRYVWQMVVQETQHRLEGAVRELTVRQTHTFLDGLARLLENTRWVVSNAPQSAIDAINRGASSVSSGYSSLSDYYRQLGLNPPQRRALFNRIEGSMGNGGPTPAAHIQDESGEVIKFYQAPGGAHQRVTPDWMLPLILGLYGDITPTWATVIEEDGPQKKKRRL
What is the function of this protein?
Structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers.  Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane.  Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2 or VP3 nuclear localization signal (shared C-terminus).  Plays a role in virion assembly within the nucleus (By similarity).
What are the official names of this protein?
Minor capsid protein VP2, Minor structural protein VP2.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses capsid protein VP2 family.
What are the subcellular locations of this protein?
[Isoform VP2]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane. SUBCELLULAR LOCATION: [Isoform VP3]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane.
Protein: SPB4_NEUCR
Sequence: MAPTQPQTKVRKPPRSWDALTPPLAQWILDYLSSMGFTQPTPVQKSCLELFRGNKDVVVEAVTGSGKTLAFLIPVVEKLLRGEEPAKRNHVQGIIISPTRELATQIYNVLVSLVKFHEPSAEAISHAKSDEKRPTATQPVVVPQLLVGGTTKAAEDLGTFLRLSPNLLIGTPGRLAELLSSAYVKAPASTFEVLIMDEADRLLDMGFANELNRILGYLPKQRRTGLFSASLSDAVERLITVGLLYPHKITVRVKSLKDGGIIQERKTPMSLQMSYLVTPASQKMPAIVQLLEKLEPRPQRSIIFFSSCMAVKYFSRILGAVLPAGFSVTSLHGKLEPKVREKNYERFVNTTSPMVLLTTDLAARGLDIPQVDLVIQHDPPTDTKVFIHRCGRAGRAGRRGLAVVLLQPGREEGYVQLLEVRQTPITPLEKPAISVTPDEVERVSAAFRSQALADREIFQMAQLAFVSWTRSYIEHQASSIFRIADLDWLDLAKGYGLLELPKMPEVREAKIDRSLGLGINTEEIPFKDKVREKKRQEELAKWKEEKAKRAQEENTGDKRKKNEAWSGKAEQEETKLQRREKKRRKREAKKFSEMTEKEKEEHLKLEQMIEEVRKRNEAKAAEERAAALAANPPKPKAPVKKVDDSDEEFGGFDD
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.  Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA.  Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5. 8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
What are the official names of this protein?
ATP-dependent rRNA helicase spb-4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: FMT_LACE2
Sequence: MRVVFMGTPDFAVGTLKAIIEAGHDVAAVVTQPDKPRGRSKSLVFSPVKDEAVAHGITVLQPERARDEAFVEELRTYNADVIVVVAFGQLLPASIINMPRYGCINVHASLLPKYRGASPIQWAVIDGCEYSGVTTMKMDEGLDTGDILMVEKVKLDAKETGGSLFDRLSDVGAHLLVKTLEGLEAGTITPVKQDDSESTYVKMLHKSFGKMDFNKSAAELERLIRGLNPWPSAFTYIDGKMLKIWDADVADNISEVQTEEVKPGQVVTVGKNTFTIACGQGYLVVNEVQLEGKKRMDSGSFLRGNQLEAGVMLGE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RECX_NEIMA
Sequence: MKPQKSLRARAMDILSRQELSRIGLKRKLAPHAESEEELENVLNEFAERNWQSDLRYAEAYIRSKSRKHGSLRLKQALAQQGIDEETSRNLLPDRSSEKLAAIAVLRKKFKHPAADLKEKQKQARFLAYRGFDADTVQTALKHAWDENWEDGC
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.