PharMolix/UniProtQA huggingface dataset:
Protein: GATC_MYCTA
Sequence: MSQISRDEVAHLARLARLALTETELDSFAGQLDAILTHVSQIQAVDVTGVQATDNPLKDVNVTRPDETVPCLTQRQVLDQAPDAVDGRFAVPQILGDEQ
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: ARGDC_SULIL
Sequence: MSEQEVLQKNNSPEGKEDRIIGKHVFGNLYDIDAERLNDKEFLEKLVLEAVNIAHMKLVEIKAWSFGGKKGGVSVIALVEESHIALHTWNEYNYATLDVYTCGEDSDPQSAFAHIVNALNPKRYQMFYADRSSQ
What is the function of this protein?
Specifically catalyzes the decarboxylation of L-arginine to agmatine.  Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.
What are the official names of this protein?
Arginine decarboxylase proenzyme, ADC, ArgDC, Pyruvoyl-dependent arginine decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: Y1002_BRUA4
Sequence: MNIEPETIRILVDADACPVKAEIYRVAERHNLPVMLVANSFIAIPRDAERVERVIVSDKLDAADDWIAENSRPGAIVITADIPLASRSLEKGASVIAPNGRVHTQSTIGNTLATRNLMDSLRSAGEVTGGPAPFSPKDRSAFLSALDLAIVRLKRAGFVSG
What are the official names of this protein?
UPF0178 protein Oant_1002.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: PP304_ARATH
Sequence: MVVSKVNKSLLSSVFKSRIRPTGESSIASGNKDIAGTSQAVKDLLSSKNSSSDLEEASLQDRVSKLLHVTTSDKSSLEKNLFLKIPSFTTKIPYDISLRTKELSRERKERRVYKQNGLSRRFAKIFRDSAQKLGTEAMFGAFDRVAKEMSVTEYNAMIGVYLEHAEKSNDLDYALGHIEKAFELLKSMRDRGFLIEERVYGPLLGYLIGMDMVDEFHSFKDVIREASPGSVERLGYYEMLLWIHLGDGEKIEELCSTIDGDNGESLSVLQENYLLALCKKDQKYHLERLLEIVDITKVRSSDLLANIFEYLGRFSLDSVASRFLWELRESDEGVKNVSDLISIYSTCTPNPTVEDTILKFNKMHEELDVMPSSTSYEKLVKYSCDSNEVVTALDVVEKMGEAGLMISADILHSLLHAIDEVLEFDLVRRIHSIMCTKSVKPNTENFRSIIRLCTRIKDFEGAYNMLGNLKNFNLEPNSSMFNCILAGYFREKNVSSALMVVKQMKEAGVKPDSITFGYLINNCTQEDAITKYYEEMKQAGVQATKRIYMSLIDAYAASGKFEKAKQVLVDPDVPAINQNELKSVLISALASRGKWADALHIYEEMRKAECHVDPKSIISLIEYSDSKGELSTLVQLADDLQDDTSWIDGFFRMILFAVRNKKSSDIVDLLKRNKVRLLKKGIPVEAHFDEVFWAIAETEPSKVHLGMDLLRFMKDELGFVPSRKCLDFLLHACVNAKDLEHGLLVWKEYQSAAFPCNVLSFLRMYQVLLAAGDSEGAKALVSKIPKDDKDVQHIIEESQSAFSQAPNKKKPKKKMIVLSTK
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At4g04790, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MOMPM_CHLMU
Sequence: MKKLLKSVLAFAVLGSASSLHALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISLRLGYYGDFVFDRVLKTDVNKQFEMGAAPTGDADLTTAPTPASRENPAYGKHMQDAEMFTNAAYMALNIWDRFDVFCTLGATSGYLKGNSAAFNLVGLFGRDETAVAADDIPNVSLSQAVVELYTDTAFAWSVGARAALWECGCATLGASFQYAQSKPKVEELNVLCNAAEFTINKPKGYVGQEFPLNIKAGTVSATDTKDASIDYHEWQASLALSYRLNMFTPYIGVKWSRASFDADTIRIAQPKLETSILKMTTWNPTISGSGIDVDTKITDTLQIVSLQLNKMKSRKSCGLAIGTTIVDADKYAVTVETRLIDERAAHVNAQFRF
What is the function of this protein?
Permits diffusion of specific solutes through the outer membrane.
What are the official names of this protein?
Major outer membrane porin, MOMP.
What is the protein family that this protein belongs to?
Belongs to the chlamydial porin (CP) (TC 1.B.2) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: FENR2_CUPTR
Sequence: MDLSIPNPVADATRQVEGGSPAGGQPLEIDALIVGAGPVGLFQVFELGLLEIKAHVIDSLKVVGGQCVELYPDKPIYDIPAVPSCTGQELTDNLLKQIEPFEPTFHLGQEVSVVERRDDGRFFVETSLGTRFITKTIFIAAGVGSFQPRTLKVDGIDKFDGKQLFYRVKDPSRFHGRNLVIVGGGDSALDWTLDLVGKAESVVMIHRRDGFRAAPASVAKMKELCEQMEMQFLVGQISGYEEKDGVLTEIKVSGADGVTRRLPLDDLLVFFGLSPKLGPIAEWGLDLERKQIKVDTEKFQTNIPGIFAVGDINTYPGKKKLILSGFHEAALAAFGAAPYIFPEKKIHMQYTTTSPKLHKVLGVESPVFD
What are the official names of this protein?
Ferredoxin--NADP reductase 2, FNR 2, Fd-NADP(+) reductase 2.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: ACCA_CHLPB
Sequence: MATKVVLDFEKPLFELEEKLNEMRVCLKQSSGEHNLSETESLSREIEVLESKVDALRHAIYKNLTRWQKVQLARHPERPFTLDYIYMMMQDFVELSGDRHYGDDKALIGGFARIEDEERDFSQTVMVIGHQKGRDTKSNLYRNFGMSQPEGYRKALRLMKLAEKFNKPVVTLIDTPGAYPGIKAEELGQAEAIARNLFEMAGLRVPVICVIIGEGASGGAIGIGVGNRILMAENAWYSVISPESCSSILWRSWKFKEQAAEALKLTAEDLLEQKIVDRIIPEPLGGAHHDPEKMADTVKSLLVEELRMLLEKNPDDLVNERIEKFAAMGVWNEEE
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_ANOFW
Sequence: MFRTLMNAKIHRARVTEANLNYVGSITIDEDILDAVGMVPNEKVQIVNNNNGARFETYIIPGERGSGVFCLNGAAARLVQKDDIIIVISYVLVPEEKLTSHRPKIAIMDEHNRIKELIVQEPAATVL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAIB_ECOL5
Sequence: MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKVRETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLYKCADGYIVMELVGITQITECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLAAHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKGPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
What is the function of this protein?
Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine.  Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
What are the official names of this protein?
L-carnitine CoA-transferase, Crotonobetainyl-CoA:carnitine CoA-transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. CaiB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZO1_STAS1
Sequence: MKGLIIVGSAKVGSHTTALSQYLKGHFEEHDFDVEIFDLAEQPIHQLDVSGASNLSESYKNNLQTLKTKAREADFFVLGSPNYHGSYSGILKNALDHLTMDDFKMKPVGLIGNSGGIVSSEPLSHLRLIVRSLLGIAVPTQIATHDTDFKKLDDGTYYLANEEFQLRARLFVDQIISFVKNSPYEHLK
What is the function of this protein?
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines.  Requires NADPH, but not NADH, as an electron donor for its activity (By similarity).
What are the official names of this protein?
FMN-dependent NADPH-azoreductase, NADPH-dependent flavo-azoreductase, NADPH-flavin azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 2 family.
Protein: RNPH_RICFE
Sequence: MRQSGRKSNQLRPISLELSPLINAEGSCLIKIGNTHVMCSATCETTVPPFLRGQNQGWVTAEYGMLPGSTSQRIKREAAQGKQGGRTQEIQRLIGRNMRCVIDLKKLGERQIIIDCDVINADGGTRTAAITGSYVALHLAIRSLMKKRILKVNPLISQIAAVSCGIYKGEAILDLDYLEDSDAEVDSNFVFAGNGNLIEVQGTAEKEPFSEEQFIAMLKLAKGGAAELFKLQNQVLLGA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: O10G4_HUMAN
Sequence: MSNASLVTAFILTGLPHAPGLDALLFGIFLVVYVLTVLGNLLILLVIRVDSHLHTPMYYFLTNLSFIDMWFSTVTVPKMLMTLVSPSGRAISFHSCVAQLYFFHFLGSTECFLYTVMSYDRYLAISYPLRYTSMMSGSRCALLATGTWLSGSLHSAVQTILTFHLPYCGPNQIQHYFCDAPPILKLACADTSANVMVIFVDIGIVASGCFVLIVLSYVSIVCSILRIRTSDGRRRAFQTCASHCIVVLCFFVPCVVIYLRPGSMDAMDGVVAIFYTVLTPLLNPVVYTLRNKEVKKAVLKLRDKVAHPQRK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 10G4, Olfactory receptor OR11-278.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLGA_PSEPF
Sequence: MASQNPNKKKVLFVTSEIADLVKTGGLGDVSAALPRAMAHLHDVRVLIPGYPQVMNSENPIHIIGELGGHAALPPCKIGRMDMPDGLVIYVLICPELYARDGGPYGANNGRDWPDNHIRFARLGLAAADIAANLAQIHWCPDLVHAHDWPAGLAPAYMHWRGQRTPTLFTIHNLAYQGVTSLGSCPELGIPAHALQQEGMEFYGKMSFLKAGMAYSSHITTVSATYAQEITTPDFGCGLDGFLAAKTQQGLLSGIPNGIDESWDAATDPHLFAPFAIGDWEGKAINAAHVRELFGLKDSEGPLFAVVSRLVYQKGLDLTEAVSEYIVQNGGQIAIIGRGEPEEEQAMRELALRFPGQIGVRIGFNETDARRMFAGSDFLLMPSRYEPCGLSQMYAQRFGSLPVARNTGGLADTIENGVTGFLFNESTADSYREALSRAFKVFAFPELLNAMRCRAMAAPFNWCKAVEPYAELYEKLVAKALGKTHHK
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: PYRH_SHEB5
Sequence: MSTNPKPAFRRILLKLSGEALMGDEGFGIDPKVLDRMAQEVKELVELGIQVGVVIGGGNLFRGEGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLKGVCDDYNWAEAISLLKSGRVVIFAAGTGNPFCTTDSAACLRGIEIEAEVVLKGTKVDGVYSEDPMKNPDAVKYDEVTYAEILEKELKVMDLAAFTMARDHDMPILVFNMNKPGALRRVIMGEEEGTLIRAKKVI
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_XANCB
Sequence: MRLSQFHLHTTKETPADAELVSHRLMLRAGMIRKLASGLYTWSPLGLRVLRKVEAIVREEMNRAGAVEVLFPTIQPRELWDATGRWEKFGGQLLKIKDRKEQEFCYTPTAEEAAAEFARQEINSYKQLPLNFYQIQTKFRDEIRPRFGVMRAREFLMKDAYSFHLTDADMAREYDNMRAAYIRIFTRLGLEFRAVQADSGAIGGDASQEFHVIAESGEDSLAFSTGSDYAANVETASAALPAPRPAAGETLQRVDTPTQKTCEDVAQLLGLPLQRTVKSIAVMTTAGFVLVLVRGDHAVNEIKLAKVAGMADYRLANESEIRQHLGSEPGFLGPVQPVQPIRIIADRDVATMADFVVGANAVGVHLTGVNWGRDLPEPETVADVRNVVDGDRASDGGELRLTRGIEVGHVFQLGSKYAEALQATVLDENGKAAVMKMGCYGIGISRIVAAAIEQNHDDAGIVWPAPMAPWKVVVCVINPKQDAQVAAAAGDLLEELIAAGIDAALDDRGLRPGAMFADMELLGIPHRVVVSERGLAAGTFEYRARTAESAENLDKAGLFSRLGH
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL28B_NONUL
Sequence: MRKLKYNTTRVILMIAFISLSACSSEDAMIEEEQVIPDPDPVAQTDEDTGPVVDCTNQGTNPTRDTDIPNPRNIGDIDDRSCYANYSESSILGKFWGIYNITDGSNHMDAPNTLQPRIERSLSRSQATGAGSYARFRGVLRILEVGDTGTFSSSGSYFMQAKGKHTGGGGSPDPAICLYRAHPVYGDDGNGNQVQVSFDIWREQINFRGGSGSAGRTEVFLKNVLKNEQIDIELEVGFRDDPNNPGQTLHYADAKIGGEEFNWNIPEPERGIESGIRYGAYRVKGGRAQFRWANTSYTKDEVN
What is the function of this protein?
Ulvan lyase involved in ulvan degradation (PubMed:29875159).  Ulvan is the main polysaccharide component of the Ulvales (green seaweed) cell wall.  It is composed of disaccharide building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl).  Ulvan lyase catalyzes the endolytic cleavage of the glycosidic bond between Rha3S and the uronic acids GlcA or IduA, producing oligosaccharides that have unsaturated 4-deoxy-L-threo-hex-4-enopyranosiduronic acid (deltaUA) at the non-reducing end.  This results eventually in the degradation of the ulvan polysaccharide into deltaUA-Rha3S disaccharides and deltaUA-Rha3S-Xyl-Rha3S tetrasaccharides (By similarity).
What are the official names of this protein?
Ulvan lyase NLR48.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 28 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: DRN1_STREQ
Sequence: MSKKLRNFLVRIIVAAFASFAVMAIPPYHHNTVLAKTVSVNQTYGEYKDYYTVIGESNIDQSAFPKIYKTTERVYKGQGTSEKRVTVSDVVYNPLDGYKRSTGAYGVVTKDMIDMSKGYREKWETNPEPSGWFRFYNRADNEEISEKEYDSRRTKSYKVTNNVPVVLTTLKGKKYNSHLFVASHLFADSLGGKSIRKNAITGTQMQNVGTRKGGMQYIEKKVLSHITKNPDVYVFYSAIPEYQGAELLARSVLVSALSSDGVINETVRVFNTADGFNINYEKGGLLTESPVSEIDNIEDSTTDEIENSVDDSEEIVYNDTTTEEEEN
What is the function of this protein?
May have a role in S. equisimilis virulence.
What are the official names of this protein?
Deoxyribonuclease, DNase, Streptodornase.
Protein: THIG_BACAN
Sequence: MLNIGPFSFHSRLLLGTGKFPDFDVQQKAIDVSEAEVLTFAVRRMDIFDAKQPNLLEKLDVKKYKLLPNTAGAKNAEEAVRIAKLAKASGLCDMIKVEVIGDDRTLLPDPVETLRASEMLLEEGFIVLPYTSDDVVLARKLQELGVHAIMPGASPIGSGLGIVNPLNLSFIIEQATVPVIVDAGIGSPADAAFAMELGADGVLLNTAVSGAKDPIKMAQAMKLSIEAGRLGFEAGRIARKRCATASSPLEGMSVVE
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_PSEPK
Sequence: MARFFRRRKFCRFTAEDVKEIDFKDLNTLKAYVSETGKIVPSRITGTKARYQRQLATAIKRARFLALLPYTDSHGR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: NU3M_SQUAC
Sequence: MNLIMSSVAATALISLILAFVAFWLPSLNPDNEKLSPYECGFDPLGSARLPFSLRFFLVAILFLLFDLEIALLLPLPWGNQLLTPSISLLWATSIIILLTLGLIYEWLQGGLEWAE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: RDRP_ROTYO
Sequence: MGKYNLILSEYLSFVYNSQSAVQIPIYYSSNSELEKRCIDFHVKCVDYSKRGLSLKSLFEEYKDVIDDATLLSILSYSYDKYNAVERKLINYAKGKPLEADLTVNELDYENNKITSELFQSAEEYTDSLMDPAILTSLSSNLNAVMFWLERHSNDVADANKIYKRRLDLFIIVASTINKYGVPRHNEKYRYDYDVMKDKPYYLVTWANSAIEMLMSVFSHEDYLIAKELIVLSYSNRSTLAKLVSSPMSILVALIDINGTFITNEELELEFSDKYVKAIVPDQTFNELQEMIDNMKKAGLVDIPRMIQEWLIDCSLEKFTLMSKIYSWSFHVGFRKQKMIDAALDQLKTEYTDDVDNEMYYEYTMLIRDEIVKMLEIPVKHDDHLLQDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDIAHGRYTPGVIPPVNVDRPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLSYAKHTREYAEFYSQSNQLLSYGDVTRFLSSNSMVLYTDVSQWDSSQHNTQPFRKGIIMGLDMLTNMTNDPKVVHTLNLYKQTQINLMDSYVQIPDGDVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRIANKYSFITKIIRVDGDDNYAVLQFNTDVTKQMVQEVSDDVRYIYSRMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYSNYIVNKLRGFETDREFILTKIIQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADEIASSQTFKNYVSKLSDQLLVSKNTIVSKGIAVTEKAKLNSYAPVYLEKRRAQISALLTMLQKPVSFKSNKITINDILRDIKPFFVTTEANLPIQYRKFMPTLPDNVQYVIQCIGSRTYQIEDSGSKSSISKLISKYSVYKPSIEELYKVISLREREIQLYLVSLGVPLIDASTYVGSRIYSQDKYKILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEIINHAIKNRAWISLFCNYPKSEMIKLWKKMWNITALRSPYTSANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).
Protein: RLMKL_SHISS
Sequence: MNSLFASTARGLEELLKTELENLGAVECQVVQGGVHFKGDTRLVYQSLMWSRLASRIMLPLGECKVYSDLDLYLGVQAINWTEMFNPGATFAVHFSGLNDTIRNSQYGAMKVKDAIVDAFTRKNLPRPNVDRDAPDIRVNVWLHKETASIALDLSGDGLHLRGYRDRAGIAPIKETLAAAIVMRTGWQPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGRWGFSGWVQHDEAIWQEVKAEAQTRARKGLAEYSSHFYGSDSDARVIQRARTNARLAGIGELITFEVKDVAQLTNPLPKGPYGTVLSNPPYGERLDSEPALIALHSLLGRIMKNQFGGWNLSLFSASPDLLSCLQLRADKQYKAKNGPLDCVQKNYHVAESTPDSKPAMVAEDYANRLRKNLKKFEKWARQEGIECYRLYDADLPEYNVAVDRYADWVVVQEYAPPKTIDAHKARQRLFDIIAATISVLGIAPNKLVLKTRERQKGKNQYQKLGEKGEFLEVTEYNAHLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSATVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLIQADCLAWLREANEQFDLIFIDPPTFSNSKRMEDAFDVQRDHMALMKDLKRLLRAGGTIMFSNNKRGFRMDLDGLAKLGLKAQEITQKTLSQDFARNRQIHNCWLITAA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_CLOBM
Sequence: MNIKPEEITSIIRQQIENFNTNIETIDSGTIIQIGDGIARVYGLEDCMEGELIEFPNDVYGMALNLEQDNVGCVLLGSEEGIKEGNVVKRTKKVVEVPVGEALVGRVVNSLGMPIDGKGPVLTTETRDVEVPAPGVIDRQSVKEPLQTGIKAIDSMIPIGKGQRELIIGDRQTGKTAIAMDTILNQKGKDVICIYVAIGQKQSTVAHIVNDLTKMGAMDYTIVVSSTASDSAPLQYLAPYAGCSMGEYFMHKGKDVLIVYDDLSKHAVAYRTMSLLLRRPPGREAYPGDVFYLHSRLLERSARLSEKLGGGSLTALPIVETLAGDVTAYIPTNVISITDGQIFLESELFNAGQRPAVNAGISVSRVGGNAQIKAMKQVAGTLRLELAQYRELAAFSQFGSDLDKESVKRLEKGKRLVEILKQPQYGPMPVEKEIIILYAAVSNHLIDIPVNKIKEFEKELFNYIDTHYRDIGKDILEHKQLTDELKSKLDKAINDFKNVFLSEI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SSRP_SALHS
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANIGDSYVILKDGEAWLFGANFTPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRINREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDLKEREWQLDKARIMKNAGR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: P2Y12_MOUSE
Sequence: MDVPGVNTTSANTTFSPGTSTLCVRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGPLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVVIWAFMFLISLPNMILTNRRPKDKDVTKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKVPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCSAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLTSMLRCSNSTSTSGTNKKKGQEGGEPSEETPM
What is the function of this protein?
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system.  Required for normal platelet aggregation and blood coagulation.
What are the official names of this protein?
P2Y purinoceptor 12, P2Y12.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.