PharMolix/UniProtQA huggingface dataset:
Protein: CP6B6_HELAM
Sequence: MWIFYFPAVISVLIVSLYFYFTRTFNYWKKRNVRGPEPTVFFGNLKDSALPRKNMGVVMEELYNMFPEEKVIGIYRMTSPCLLVRDLEVIKHIMIKDFEVFSDRGVEFSKEGLGSNLFHADGETWRALRNRFTPIFTSGKPKNMFYLMHEGADNFIDHVSAECEKNQEFEVHSLLQTYTMSTIAACAFGISYDSIGDKVKALDIVDKIISEPSYAIELDMMYPGLLSKLNLSIFPTAVKNFFKSLVDNIVAQRNGKPSGRNDFMDLILELRQLGEVTSNKYGSSASSLEITDEVICAQAFVFYIAGYETSATTMAYMIYQLALSPDIQNKLIAEVDEVLKANDGKVTYDTVKEMKYMNKAFDETLRMYSIVEPLQRKATRDYKIPGTDVVIEKDTIVLISPRGIHYDPKYYDNPKQFNPDRFDAEEVGKRHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKILSKFRIEPSKNTDRNLQVEPHRGLIGPKGGIRVNVVPRKLVS
What are the official names of this protein?
Cytochrome P450 6B6, CYPVIB6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RHGBA_HUMAN
Sequence: MWDQRLVRLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEDHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKATLLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAAVVQTLIDYASDIGRVPDFILEKIPAMLGIDGLCATPSLEGFEEGEYETPGEYKRKRRQSVGDFVSGALNKFKPNRTPSITPQEERIAQLSESPVILTPNAKRTLPVDSSHGFSSKKRKSIKHNFNFELLPSNLFNSSSTPVSVHIDTSSEGSSQSSLSPVLIGGNHLITAGVPRRSKRIAGKKVCRVESGKAGCFSPKISHKEKVRRSLRLKFNLGKNGREVNGCSGVNRYESVGWRLANQQSLKNRIESVKTGLLFSPDVDEKLPKKGSEKISKSEETLLTPERLVGTNYRMSWTGPNNSSFQEVDANEASSMVENLEVENSLEPDIMVEKSPATSCELTPSNLNNKHNSNITSSPLSGDENNMTKETLVKVQKAFSESGSNLHALMNQRQSSVTNVGKVKLTEPSYLEDSPEENLFETNDLTIVESKEKYEHHTGKGEKCFSERDFSPLQTQTFNRETTIKCYSTQMKMEHEKDIHSNMPKDYLSKQEFSSDEEIKKQQSPKDKLNNKLKENENMMEGNLPKCAAHSKDEARSSFSQQSTCVVTNLSKPRPMRIAKQQSLETCEKTVSESSQMTEHRKVSDHIQWFNKLSLNEPNRIKVKSPLKFQRTPVRQSVRRINSLLEYSRQPTGHKLASLGDTASPLVKSVSCDGALSSCIESASKDSSVSCIKSGPKEQKSMSCEESNIGAISKSSMELPSKSFLKMRKHPDSVNASLRSTTVYKQKILSDGQVKVPLDDLTNHDIVKPVVNNNMGISSGINNRVLRRPSERGRAWYKGSPKHPIGKTQLLPTSKPVDL
What is the function of this protein?
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
What are the official names of this protein?
Rho GTPase-activating protein 11A, Rho-type GTPase-activating protein 11A.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECA_RHOPB
Sequence: MIGALARRLFGSPNDRRIKAYQPRVDAINALEPELVALSDEALRGRTAEFRQQLADGKTLDDILVPAFATVREAAKRTLGQRHFDVQLIGGMVLHEGDIAEMKTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLARRDSAWMGEIYGFLGMTTGVIVHGLDDQQRQAAYACDITYGTNNEYGFDYLRDNMKYRLEDMVQRGHYYAIVDEVDSILIDEARTPLIISGPLDDRSEFYNTIDTFMPSLDKATDYEVDEKQRTVTLTEAGMEHIEVLLRDAGQLKGDSLYDVENVSVVHHVNQALRAHSLFQRDKDYIVRDDEVVIIDEFTGRMMPGRRYSEGLHQALEAKEHVQVQPENQTLASITFQNYFRMYEKLSGMTGTALTEADELFDIYKLEVVEIPTNVQIARLDEDDEVYRTQSEKYAAILAEVERANSRLQPVLVGTASIEKSEVLGEYLKKHGYKQIDFTDPKGMEKLYAAARAGKPAKLFAVLNARFHEQEAYIVAEAGVPGAITIATNMAGRGTDIKLGGSLEMRIQHETVGITDEAEKAAKIELIKADIERFREIVLKAEEVVEVEPAKGNKPAKTLTRPGGLYIMGSERHESRRIDNQLRGRSGRQGDPGRSKFFLSLEDDLMRIFGSDRLDTMLTRLGLKEGEAIIHPWINKALEKAQQKVEARNFDIRKNLLKFDNVQNDQRKEIFDHRISLMKDDSVAETVAGMRHDFIDDIVAKHVPEHAYAEQWDVAGLKEELERVLGLDLPVDEWAKEEGIADEELLTRIEQRVDEHMAAKVGQWGPEVMRYAEKSILLQTLDHLWREHLVMLDHLRNVIGLRGYGQRDPLQEYKSEAFALFEAMITHLREAVTAQLMRVEIVPPEQPQELPPMEGHKFNADTGEDDMAFANVSLAPADNADKTARNPNDPSTWGKVGRNEDCPCGSGKKYKHCHGRYA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ZB182_XENLA
Sequence: MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLQFMYEGKLEFSNLPVEDVLAAASYLHMYDIVKVCKGKLKDKELNSGEKIIDDGEKDDKPVDSEEHHEHSFDASQQKISTLDSVKPIWKEKVSGLSGLSSDLIGVNSVPAEAVMCKRAAGKTKANDSSPSSPLSQRSANHTHPPSDRDGALDLSFKPMPGRDSFHPSYVFGQLVSDSQQQGSLPLVKHEQDLLSEQEDSQAKSPKSQQVGNPAKSLVTGLGHMFTGNGNSHTREDDLYQDRDESEDEMDSSDLSTSGVLVSPGQICICPLCSKVFPSPHILQLHLSSHFKDKDNSRIKMSPDGSVPTCTICGKTFSCMYTLKRHERTHSGEKPFTCGQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCGLVKSLVV
What is the function of this protein?
Transcriptional repressor that plays a role in various developmental processes.  Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes (By similarity).
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 18.2, Zinc finger protein 238.2.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ILVC_PSYCK
Sequence: MNVYYDKDCDLSIVQGKKVAIIGYGSQGHAHALNLQDSNVDVTVGLRANSGSWKKAENAGLKVAEVEEAVKAADIIMILTPDEFQKELYNDVIEPNIKQGATLAFAHGFAIHYNQVIPRSDLDVIMVAPKAPGHTVRSEFAKGGGIPDLIAIYQDASGQAKQLALSYAAGVGGGRSGIIETTFKDETETDLFGEQAVLCGGAVELVKMGFETLTEAGYAPEMAYFECLHELKLIVDLMYEGGIADMNYSISNNAEYGEYVTGPEVINEQSREAMRNALKRIQSGEYAKMFISEGATNYPSMTARRRNNAEHQIEITGAKLRGMMPWIGGNKIIDKDKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: COBE_SINSX
Sequence: MPSGQHSAQTTKAGAGLVLGLGCERRTPAEEVIALAERALADAGVAPGDLRLVASLDARAEEPAILAAAQHFAVPAAFYDAATLEAEASRLANPSEIVFAYTGCHGVAEGAALVGAGREAVLIVQKIVSAHATAALAGPATLRAEKRIQAAEAV
What are the official names of this protein?
Protein CobE.
Protein: TFE_HYPBU
Sequence: MSSEIEKLFTFVEKLVDSDARKVFEALYEAGEELSEADIATKTGLKLNVVRRALNSMAEKGLVVYRRQKHPQKNKLVFYWRINYEGLPSIIESRKRAAHEKLRTLLEKEESVHYYVCPRDGTRYTFEEALDHEFICPRCGSMLVLDEERELRIQILKQYIKMLEDELGGAKAS
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: IDI2_LISMC
Sequence: MQKNDDLLRERRKDEHVALGVKQNEQLAPSSLEDIQLIGTSIPRYNVKDIDLTTTIVGTNVPFPLYINAMTGGSRHTKKINAELAEIAREAAIPMAVGSQSAALKNSSLIDTYKIVREINPNGMILANISPEVALQEGLRAIEMLEANALQIHINPAQELVMQEGDRSFSHWLTRIEEYVKLSPVPVVVKEVGFGMTRETVKTLADIGVQTVDLAGKGGTNFAQIENDRRRDQAYDFLLDWGISTGQALIDMQHQDAPKIAYLASGGIRNPLDIVKALALGADSVGMAGQIIYSLKKEGVTKTIEKLELWKEQLRGLFVLANAKNISELKTTPLIISGELAKWGALREIDLVKLANRK
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRO25_ORYSJ
Sequence: MKIIFVFALLAIVACNASARFDPLSQSYRQYQLQSHLLLQQQVLSPCSEFVRQQYSIVATPFWQPATFQLINNQVMQQQCCQQLRLVAQQSHYQAISIVQAIVQQLQLQQFSGVYFDQTQAQAQTLLTFNLPSICGIYPNYYSAPRSIATVGGVWY
What is the function of this protein?
Seed storage protein; serves as a source of nitrogen, carbon and sulfur for the young developing seedling.
What are the official names of this protein?
13 kDa prolamin C.
What is the protein family that this protein belongs to?
Belongs to the prolamin family.
What are the subcellular locations of this protein?
Vacuole, aleurone grain. Note=In rice, prolamin accumulates as a type I protein body which originates directly from the endoplasmic reticulum.
Protein: Z280C_MOUSE
Sequence: MDKDNSVQEKGLFLSSWKLDNSKMAELFMECEEEELEPWQQKVEESQSKDDDDELIFVGEISSSKPAISNILNRCSPGSSSKGLKNGSFNPAISNIFKPTSQHYRNPSSNALVALPSFHPALKSSESSDGQTVSKLDFTKTSPQEDSGACSVSQSDSTQDIPSSNILQPRTGVDQTLGLKHPSTSKVNSVNPKKPKTSASISETRPCSSSSSQTAPSGASSQTVLSNVNTSSVQSAPGSSSLRSCPKCNVKFRLLDPLKCHMKRCCPDMINKFLETLKSENSKAVSKATTDSDKEKLIMLVSDFYYGRHEGTIEESQKTHTTFKCFSCTKVLKNNIRFMNHMKHHLELEKQNNETWESHTTCQHCYRQYPNPFQLQCHIESTHTPHDFSTICKICELSFETEHMLLQHMKDTHKPGEMPYICQVCQFRSSIFSDVETHFRSSHENTKNLLCPFCLKVSRMATPYMNHYMRHQKKGIYRCPKCRLQFLTSKEKTEHKLEHRTFIKPKELEGLPPGTKVIIRASLGSSQSRASSPPSSTIPSTSLQLSVPKSKSTTTKNNSKVSANKATTTSPQTVATTTGKPSASKPGTGTTKSKAKPSYKQKRQRTRKNKFSIDLKNLRCHQGSHMCIECRSKIKDFSSHFSTHINCDFCKYTTNCNKAFTNHMSSHNDHPSKQLYIFKKQSRARRGITLVCLKCDFLADTSGLDRMAKHLNQRKTHTCQVVIENVTERAVTSESASDGLFK
What is the function of this protein?
May function as a transcription factor.
What are the official names of this protein?
Zinc finger protein 280C, Suppressor of hairy wing homolog 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURA_MICLC
Sequence: MPAIAIVGAQWGDEGKGKATDLLGGRVDYVVKPNGGNNAGHTVVVNGEKFELKLLPAGILSPNAVPVIGNGVVVNLEALFEEIDGLESRGHSCEHLKISANAHLVAPYHQTMDKVTERFLGQRAIGTTGRGIGPTYMDKVARLGIRVQDIFDESILRQKIEGALRQKNELLVKLYNRRAVTVDEIAEYFLGYADRLRPMVVDSVNLLNDALDEGKVVLMEGGQATYLDVDHGTYPFVTSSNPTAGGAAVGAGIGPTRFSRTIGIVKAYTTRVGAGPFPTELFDEMGEQLRTTGGEFGVNTGRPRRTGWYDAVMAHYAARINGFTDYFLTKLDVLTGIEKIPVCVAYEVDGVRHDRMPMTQTEFHHAKPVYELFDGWTEDISGARAFTDLPLNAQHYVEALEKLSGCRISAIGVGPGRDQVVQVRDLIQD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPQ_ECO57
Sequence: MESLASLYKNHIATLQERTRDALTRFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQASEEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: PTP24_STYPL
Sequence: WMMIVEQKCRVIVMLAKCFEAGKKKCQKYWPDSKEAKTFGRVKVFNAEEVKYCGFLRRRFYIDSFDEMMSVEVFQYQYINWPDHSVPNTTSNLVRMHKYVIQCLEETGSDAPMVV
What are the official names of this protein?
Tyrosine-protein phosphatase 24.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: PA_I83A8
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEETIEEKFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYIVKPHEKGINSNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSEAWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: ASHR1_ARATH
Sequence: MADLQRFLQDRCLGVSNLPQKGRSLFTARDFRPGEVILSQKPYICVPNNTSSESRCDGCFKTNNLKKCSACQVVWYCGSSCQKSEWKLHRDECKALTRLEKEKRKFVTPTIRLMVRLYIKRNLQNEKVLPITTTDNYSLVEALVSHMSEIDEKQMLLYAQMANLVNLILQFPSVDLREIAENFSKFSCNAHSICDSELRPQGIGLFPLVSIINHSCSPNAVLVFEEQMAVVRAMDNISKDSEITISYIETAGSTLTRQKSLKEQYLFHCQCARCSNFGKPHDIEESAILEGYRCANEKCTGFLLRDPEEKGFVCQKCLLLRSKEEVKKLASDLKTVSEKAPTSPSAEDKQAAIELYKTIEKLQVKLYHSFSIPLMRTREKLLKMLMDVEIWREALNYCRLIVPVYQRVYPATHPLIGLQFYTQGKLEWLLGETKEAVSSLIKAFDILRISHGISTPFMKELSAKLEEARAEASYKQLALH
What is the function of this protein?
Histone methyltransferase.
What are the official names of this protein?
Histone-lysine N-methyltransferase ASHR1, ASH1-related protein 1, Protein SET DOMAIN GROUP 37.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CISH_BOVIN
Sequence: MVLCVQGLCPLLAVEQIGQRPLWAQSLELPQQVMQPLSAGAFLEEAVEESPAQPEREPKVVDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDLATTPALPTPKEDAPGDPALPATAVHLKLVQPFVRRSSTRSLQHLCRLVINRLVVDVDCLPLPRRMADYLRQYPFQL
What is the function of this protein?
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction.  CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor.  Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity).  May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
What are the official names of this protein?
Cytokine-inducible SH2-containing protein, CIS.
Protein: PSAB_AETCO
Sequence: MALRFPRFSQGLAQDPTTRRIWFGIATAHDFESHDDITEERLYQNIFASHFGQLAIIFLWTSGNLFHVAWQGNFETWVQDPLHVRPIAHAIWDPHFGQPAVEAFTRGGALGPVNIAYSGVYQWWYTIGLRTNEDLYTGALFLLFLSAISLIGGWLHLQPKWKPRVSWFKNAESRLNHHLSGLFGVSSLAWTGHLVHVAIPASRGEYVRWNNLLNVLPHPQGLGPLFTGQWNLYAQNPDSSSHLFGTSQGSGTAILTLLGGFHPQTQSLWLTDIAHHHLAIAILFLIAGHMYRTNFGIGHSIKDLLEAHIPPGGRLGRGHKGLYDTINNSIHFQLGLALASLGVITSLVAQHMYSLPAYAFIAQDFTTQAALYTHHQYIAGFIMTGAFAHGAIFFIRDYNPEQNEDNVLARMLDHKEAIISHLSWASLFLGFHTLGLYVHNDVMLAFGTPEKQILIEPIFAQWIQSAHGKTSYGFDVLLSSTNGPAFNAGRSIWLPGWLNAINENSNSLFLTIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAVFWMLNTIGWVTFYWHWKHITLWQGNVSQFNESSTYLMGWLRDYLWLNSSQLINGYNPFGMNSLSVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLAWAHERTPLANLIRWKDKPVALSIVQARLVGLAHFSVGYIFTYAAFLIASTSGKFG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PA21B_CANLF
Sequence: MKFLVLAALLTVAAAEGGISPRAVWQFRNMIKCTIPESDPLKDYNDYGCYCGLGGSGTPVDELDKCCQTHDHCYSEAKKLDSCKFLLDNPYTKIYSYSCSGSEITCSSKNKDCQAFICNCDRSAAICFSKAPYNKEHKNLDTKKYC
What is the function of this protein?
Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract.  Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines.  May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract.  Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity).  May act in an autocrine and paracrine manner (By similarity).  Has anti-helminth activity in a process regulated by gut microbiota.  Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity).
What are the official names of this protein?
Phospholipase A2, Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.
Protein: SECA_CYTFI
Sequence: KLAGMTGTAKTEEEEFRNIYGMDVMVIPTNKPIARIDKPDLIYKTMEAKFRAVVNEIEEIHKKGQPVLVGTVSVETSELVSKLLNKRRVPHHVLNAKNHEREAEIIEGAGQQGAVTIATNMAGRGTDIKLGEGVRELGGLHVLGTERHESRRIDNQLRGRAGRQGDPGSSQFYLSMEDELMRRFGSDNMRSMMERLGMEEDQPIESRLVSRAVETAQKRVEGNNFDARKQILQYDDVMREQREIIYKQRMEVLESDNLRKIVETMIKDVIDRTVRLHTPENEVPEDWDLMAIVNYMNANLLQEGELEEKDIKGLDPEEMVEAITEKVIARYNEKEEQFTPEHMREFEKVIMLRTVDRKWMNHIDQMDQLRQGIHLRAYGQNDPLREYRFEGFEMFEAMIASIEEEVSMYIMKAQVQQNLERQKVAEGKAVHQDTSKQEPKKKQPIRKGETIGRNDACICGSGKKYKNCCGAGK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: CDC45_YEAST
Sequence: MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDENDNNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVKRLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYRNPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL
What is the function of this protein?
Required for initiation of chromosomal DNA replication.  Acts at the origin of replication.  Also has a role in minichromosome maintenance.
What are the official names of this protein?
Cell division control protein 45.
What is the protein family that this protein belongs to?
Belongs to the CDC45 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COXX_TRIEI
Sequence: MQQVISHSLPRRHNNILQVFKSYYQLTKPRIILLLLITTAAGMWLGAKGEVSLFLLFVTLTGGALASGAANAINCIYDSDIDYIMERTRWRPIPSGRVKPRDALIFALTLAATSFTLLTVFANLLAALLAMSGIVFYVGVYTHWLKRHSVQNIVIGGAAGAIPPLVGWAAVTGELSWAAWLLFAIIVVWTPPHFWALAIYIRDEYQEVGVPMLPVIEGNEETARQIWVYTLILIPMTLLLVYPLHVSGAIYAVLATYLGVIFIKKAWQLLKDPSNKDVARSLFKYSIYYMMLLCLVMVIDSLPFTHGITTALADSWQTFIGGAIAILF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLV9_ARATH
Sequence: MKKTSLKLMTLVLGFCFVIYLLQGPRGGSRNGDLLIARKLISLEPIETKNAARSLKDSISTDLEEEVDRLMEHEYPSPVKPRKRTPVHNGVRNRH
What is the function of this protein?
Signaling peptide (root growth factor) required during root gravitropism in a PIN2-traffic dependent manner (PubMed:23370719).  Regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells (PubMed:23370719).
What are the official names of this protein?
Protein GOLVEN 9.
What is the protein family that this protein belongs to?
Belongs to the RGF family.
What are the subcellular locations of this protein?
[GLV9p]: Secreted.