PharMolix/UniProtQA huggingface dataset:
Protein: PYRC_SALNS
Sequence: MTAPSQVLKIRRPDDWHVHLRDGDMLKTVVPYTSEIYGRAIVMPNLASPITTVDAAIAYRQRILDAVPAGHDFTPLMTCYLTDSLDADELERGFHEGVFTAAKLYPANATTNSSHGVTSVDAIMPVLERMEKLGMPLLVHGEVTHADVDIFDREARFIDTVMEPLRQRLTTLKVVFEHITTKDAAQYVRDGNDYLAATITPQHLMFNRNDMLVGGIRPHLYCLPILKRNIHQQALRELVASGFTRAFLGTDSAPHSRHRKETSCGCAGCFNAPSALGSYAAVFEEMNALAHFEAFCSLNGPQFYGLPVNTGWVELVRDEQHVPENIALADDSLVPFLAGETVRWSVKK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: MOKF_MONPI
Sequence: MRQFLSSDRINSEIPQEKSEMVGFSDIDNSSRQIKEMEAAFRSAVKTGQIPGAVIMARDHSGRLNYTRCFGARTVVRDECNRLPPMQVDTPCRLASATKLLTTIMALQCVERGLVRLDETVDRLLPDLSAMKVLEGFDAAGEPKMRERKGKITLKHLLTHTSGLSYVFLHPLLREYMAKGHLQTAEKFGIQSRLAPPAVNDPGAEWIYGANLDWTGKLVERATGLDLEQYLQENICAPLNITDMTFKLQQRPDLLARRADQTHRNKADGRLRYDDSVYFRSDGDECFGGQGVFSGPESYMKVVHSLLQRDGRLLRPETVDLMFQPALDAQTEKQMNQHMDASPHINYGGPMPMVLRRSFGLGGMIALEDLDGQKWRRKGCLTFGGGPNIVWVMLLSALRFVFFFFFFFFFCSS
What is the function of this protein?
Acyltransferase; part of the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535).  Monakolin K biosynthesis is performed in two stages (PubMed:19693441).  The first stage is catalyzed by the nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441).  This PKS stage is completed by the action of dehydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441).  Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (By similarity).  Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441).  Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutanoate produced by the diketide synthase mokB (PubMed:19693441).
What are the official names of this protein?
Acyltransferase mokF, Lovastatin hydrolase, Monacolin K biosynthesis protein F.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: TENS1_BOVIN
Sequence: MTWICLSCMLWPEDLEAPKTHHFKVKTFKKVKPCGICRQVITREGCTCKVCSFSCHRKCQAKVAAPCIPPSSHELVPVNTETAPKNVVDTGEAASRGGNTRKSLEEDSSTRVTPSVQPHPQPIRNMSTSRTTEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNVQGDSQTSICITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDNFNGHRDDGMEEVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPVLSATPNHVEHTLSVSSDSGNSTASTKTDKTDEPAPGPASAPAALSPEEKRELDRLLSGFGLEREKQGAMYHPQHLRSRPVGGPAAPSSGRHIVPAQVHVNGGALASERETDILDDELPNQDGHSVGSMGTLSSLDGVTNTSEGGYPEALSPLTNGLDKPYPMEPMVNGGGYPYESASRAVSAQAGHTAPMRPSYSTQEGLAGYQREGPHPAWPQSATTSHYGHDPNGMFRSQSFPETEPQLPPAPARGGSSREAVQRGLNSWQQQQQQQQQQQQPRPPPRQQERVHLESLGLSRPSPQPLAEPPMSGLPEFPRAASQQEIEQSIEALNMLMLDLEPATAGAPLHKSQSVPGAWPGASPLSSQPFSGSSCQSHPLTQSRSGYIPSGHSLGTPEPAPRAPLESVPTGRPYSPYDYQPCPTGPNQSYHPKSPATSSSSSFLPTTQSSVGPQQPPASLPGLTTQPQLPPKEVTSDPSRTPEEEPLNLEGLVAHRVAAYNARLQGTGRRVSSWHPPLHRLRSSSLSGVQAREKQPAEPPAPLRKRAASDGQYENQSPEPTSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPTSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPTGEEDERKVLTELSEEPRSYVESVVRTAVAGPRTQEPEPKSFSAPGAQAYGHETPLRIGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGARTPTQPLLDSGFRSGSLGQPSPLAQRNYQSSSPLPTAGSSYSSPDYSLQQFSSPEGQARSQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGRRAVNPSLAAPSSPSLSHRQVMGPLGTGFHGNTGSSPQSSAATTPGSPSLGRHPGAHQVSNLHGNVVTAPGSPSLGRHPGAHQGTLASNLHSNAVASPGSPSLGRHLGGSGSVVPGSPSLDRHVPYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSMGDRAGSLPNYATVNGKVSSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTSDLLKQGAACNVLFVNSVDMESLTGPQAISKAISETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWTKTEGGAPAKLFGFVARKQGSATDNACHLFAELDPNQPASAIVSFVSKVMLSAGQKR
What is the function of this protein?
May act as a protein phosphatase and/or a lipid phosphatase.  Involved in fibrillar adhesion formation.  Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition.  Enhances RHOA activation in the presence of DLC1.  Plays a role in cell polarization and migration.  May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton.
What are the official names of this protein?
Tensin-1.
What is the protein family that this protein belongs to?
Belongs to the PTEN phosphatase protein family.
What are the subcellular locations of this protein?
Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
Protein: TOLB_BORPE
Sequence: MTPAFRRADLTGFLRTYGAALILLLAAMLAWQPAQAQLRVDISGTGATQYPVAIADFAVDDTHGRALAEVIRADLTRTGQFRLINAAGSGLNVDSQVAHDDWRAKGADFLAYGSITRGPDGRYDVRYRLADTVKKGQLDGVAFSGTEQELRRVAHQIADRIYEKITGVRGVFSTRIAYVLKRGSTYELQVADADGQNPQVALRSREPIISPSWSPDGSRLAYVSFESGKPVVYVHTLATSARIPVANFKGNNSAPAWSPDGSQLAVALTRDGLSQIYIVSAGGGSNMRRITRSPGIDTEPNFTPDGRSIIFTSDRSGGPQIYQTGLDGGDARRLTFNGGYNISPRISPDGSTLLYVARRDGAFRIASLNLSSGSETLLTDGRDDQSPSFAPNGMQVLYAAIQNGRSVLAGVSSDGRVRQTLSVLNGEIREPTWGPFTR
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RRF_PHOLL
Sequence: MINEIKKDAQDRMEKSVEALKNQISKVRTGRASPSLLDGIIVEYYGAPTPLRQLANVIAEDARTLAITVFDRTMTPAIEKAIMASDLGLNPSSAGTTIRVPLPPLTEERRKDLIKVVRSEAEQGRVSVRNIRRDANDKIKALLKDKEISEDDERRAQDDIQKLTDNFIKKVDEALTKKEEELMEF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_PHANO
Sequence: MGIKHLYQLIQEHSPDAIKTGEIKNQFGRKVAIDASMSIYSFLIAVRSDGQQLMSETGETTSHLMGLFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKSEAHAAAEEAKETGTAEDVEKFSRRTVRVTREHNEECRRLLKLMGIPFIIAPTEAEAQCATLARGGKVYAAASEDMDTLTFNTPILLRHLTFSEQRKEPILEIHLDKVLEGLEMEREQPQFIDLCILLGCDYLDPIKGIGPSTALKLIRDHKTLEGVVAHIQSDQKKLTLPEDWPFADARQLFLEPDVCPADAPECDFKWEAPDIEGLVKFLVEEKHFNEDRVRNGAAKLQKNMKSAQQSRLEGFFKPVERTPEEKASLKRKADEKLSEKKKKQKEEAKAKKQAKSKPRTAG
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: YCF3_SACOF
Sequence: MPRSRINGNFIDKTSSIVANILLQIIPTTSGEKRAFTYYRDGMLAQSEGNYAEALQNYYEATRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAILQGDSEIAEAWFDQAAEYWKQAIALTPGNYIEAQNWLKITKRFEFE
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RS18_THISH
Sequence: MSRFFRRRKYCRFTAEGVEFIDYKDLNTLKNYITETGKIVPSRITGTSARYQRQLATAVKRARYLALLPYCDNH
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TRI13_RAT
Sequence: MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGLLEGNVRNSLWRPSPFKCPTCRKETSATGVNSLQVNYSLKGIVEKYNKIKISPKMPVCKEHLGQPLNIFCVTDMQLICGVCATRGSHTKHVFSSIEDAYTQERDAFEFLFQSFETWRRGDALSRLDTLETNKRKSLQLLTKDSDKVKEFFEKLQHTLDQKKNEILSDFETMKLAVMQTYDPEINKLNSILQEQRMAFNIAEAFKDVSEPIIFLQQMQEFREKIKVIKETPLPPSNLPTSPLMKNFDTSQWEDIKLVDVDKLSLPQDTGVLTSRSPWHPCLLLMAVVLLGLLVFFGPTVFLEWSPLEELATWKDCLSSFNSYLTKSADFVEQSVFYWEQMTDGLFVFSERVKNVSLVALNNVAEFVCKYKLL
What is the function of this protein?
Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD).  This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.  Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation.  Regulates ER stress-induced autophagy, and may act as a tumor suppressor.  Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway.  Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation.  Participates as well in T-cell receptor-mediated NF-kappa-B activation.  In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B.
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM13, Putative tumor suppressor RFP2, RING-type E3 ubiquitin transferase TRIM13, Ret finger protein 2, Tripartite motif-containing protein 13.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.
Protein: PIPB2_SALTY
Sequence: MERSLDSLAGMAKSAFGAGTSAAMRQATSPKTILEYIINFFTCGGIRRRNETQYQELIETMAETLKSTMPDRGAPLPENIILDDMDGCRVEFNLPGENNEAGQVIVRVSKGDHSETREIPLASFEKICRALLFRCEFSLPQDSVILTAQGGMNLKGAVLTGANLTSENLCDADLSGANLEGAVLFMADCEGANFKGANLSGTSLGDSNFKNACLEDSIMCGATLDHANLTGANLQHASLLGCSMIECNCSGANMDHTNLSGATLIRADMSGATLQGATIMAAIMEGAVLTRANLRKASFISTNLDGADLAEANLNNTCFKDCTLTDLRTEDATMSTSTQTLFNEFYSENI
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells.  Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane.  Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery.  Required for virulence, but not for intracellular survival and replication in phagocytic cells.
What are the official names of this protein?
Secreted effector protein PipB2, Type III effector PipB2.
What are the subcellular locations of this protein?
Secreted. Host membrane. Note=Secreted via the type III secretion system 2 (SPI-2 TTSS), and delivered into the host cell. In phagocytic cells localizes to the Salmonella-containing vacuole (SCV) and tubular extensions from the SCV, Salmonella-induced filaments (Sifs). In epithelial cells localizes to peripheral vesicles, in addition to SCVs and Sifs. Concentrates in detergent-resistant microdomains (DRMs), present on the intracellular membranes of SCVs and Sifs.
Protein: CCMF_ECOLI
Sequence: MMPEIGNGLLCLALGIALLLSVYPLWGVARGDARMMASSRLFAWLLFMSVAGAFLVLVNAFVVNDFTVTYVASNSNTQLPVWYRVAATWGAHEGSLLLWVLLMSGWTFAVAIFSQRIPLDIVARVLAIMGMVSVGFLLFILFTSNPFSRTLPNFPIEGRDLNPLLQDPGLIFHPPLLYMGYVGFSVAFAFAIASLLSGRLDSTYARFTRPWTLAAWIFLTLGIVLGSAWAYYELGWGGWWFWDPVENASFMPWLVGTALMHSLAVTEQRASFKAWTLLLAISAFSLCLLGTFLVRSGVLVSVHAFASDPARGMFILAFMVLVIGGSLLLFAARGHKVRSRVNNALWSRESLLLANNVLLVAAMLVVLLGTLLPLVHKQLGLGSISIGEPFFNTMFTWLMVPFALLLGVGPLVRWGRDRPRKIRNLLIIAFISTLVLSLLLPWLFESKVVAMTVLGLAMACWIAVLAIAEAALRISRGTKTTFSYWGMVAAHLGLAVTIVGIAFSQNYSVERDVRMKSGDSVDIHEYRFTFRDVKEVTGPNWRGGVATIGVTRDGKPETVLYAEKRYYNTAGSMMTEAAIDGGITRDLYAALGEELENGAWAVRLYYKPFVRWIWAGGLMMALGGLLCLFDPRYRKRVSPQKTAPEAV
What is the function of this protein?
Required for the biogenesis of c-type cytochromes.  Possible subunit of a heme lyase.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmF.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS14_RICCK
Sequence: MAKVSLIKKNESRKKKSQSLHNKRVALKSKIYDKNISLEERFSLVMLLAQLPRNSSPTRIRNRCELTGRPRGVTRKFGISRNKLRELIGRGVVPGVVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: RNPH_DESRM
Sequence: MDRVDGRKQGQIRPVRMTPNYNKYAEGSVLIEVGDTRVICTATVEERVPPFLKGLGKGWVTAEYSMLPRATGSRTIREAARGKLGGRTMEIQRLIGRALRSVVNLEALGERSLTMDCDVIQADGGTRTASITGAYVAMIFALNRLVEQGMLEKIPVSDFIAATSVGIVKGRPVIDLCYAEDSVAEVDMNVVMTGTGRFVEIQGTGEEATFSREEMNQLLDLAAAGIEELNKVQRQVLGDIAAKIG
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: FSHB_SHEEP
Sequence: MKSVQFCFLFCCWRAICCRSCELTNITITVEKEECSFCISINTTWCAGYCYTRDLVYKDPARPNIQKACTFKELVYETVKVPGCAHHADSLYTYPVATECHCGKCDRDSTDCTVRGLGPSYCSFSDIRE
What is the function of this protein?
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer.  Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways.  Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
What are the official names of this protein?
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted. Note=Efficient secretion requires dimerization with CGA.
Protein: MDR1_ENTH1
Sequence: MDITESEFTIFEVTPDPNELNNKRIKEIKGGKVNIKELFRYAGVFEIILLIIGIIGSIGVGCLNPLLMILTGDVVDTFVNGENFSKEGGSIKITTEEMNYEIMNSISDTINKLVLKMLYFAIGNMVAGFLQTICFFVLSEYQGIKIRSLYFKALLRQDPGWFDCHKTGELTSKIINDIQKIQDGMSLKFGRLFQTFSSFITGYLIGFIKCWDLTLVVLCMFPFIMVSMMGLGMSAGIFTMKSHKPFSEACSIAEQTIGNIRTVHSLTQERSFCESYNTKIMETDKYNIKKSIGIGTGLGCMMFFIMSSNALGSWYGNFVVRGKGGSDNVKAGTVLTVFMSVLLATQSLSQISTPINILNSAKVAAFNVYQTIDRIPDIDCQSIGGECPTECNGNIRFEDVQFVYPTRLSHHVLKGLDLEIKKGQTIALVGASGCGKSTTIQLIQRNYDPNGGRVTLDGKDIRELNIKWLRNQIGLVGQEPVLFAGTIRENIMLGAKEGATPSEEEMIECAKMANAHDFISKLPEGYDTIIGEKGALLSGGQKQRIAIARALIRNPSILLLDEATSALDTQSEKIVQEALEKASKGRTTIIVAHRLTTVRNADKICVFHQGEIIEQGKHQELMDLKGTYYGLVKRQSMEEEVDQETVENDLKKFREQEDKEVENISLEQTNLHNENSIVKQIKQEYKEEQKKLKHSNRFVLFRVIWNNYKHEYIFCTLGLIGGIGAGAAFPFYSLNFVDLIRVLMKLHPGINLTDEQANSILRSCMIIICIGIITMISFFCYVGLFMAAGEKMIGRIRRRFYYSIMHQNVSWFDRRENMVGAVTTKLTSDPTSLQGISAERVGDIIEIMSTVGFGFGIGLYFSWKLSLCILAVFPIISFFMFINGQLNSKNAAPAKAAYEQCGVTLVEVVEAMKTVQSLGKEDYFSQKYNNDLQIPKRGIIKWGPLLSITNAITNLLTFSINAYGYYLGICFMKKTINYQQDVPNFVDEIIDTFGDIQKALMTINSATTSFAQIGNVLPDVGKAVGAAKSIYNIIDRKPSIDCYSEEGETFNDVKGEIEFKNIHFRYPTRADNEVLKGISFKAEQGKTIALVGASGCGKSTTIQLIERFYDPTSGEVLLDGHNIKDLNIHFLRNQIGLVGQEPVLFAESVIDNIKRGVPEGVEVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGSQLSGGQKQRIAIARALIRNPKVLLLDEATSALDSESEKIVQDALDKASKGRTTIVIAHRLSTIQNADKIYVIMRGKIVEQGKHQELIDLKGFYYTLAMQQFGTVN
What is the function of this protein?
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug resistance parasites.
What are the official names of this protein?
Multidrug resistance protein 1, P-glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Protein: DNAK_METSS
Sequence: MAKIIGIDLGTTNSCVAVMEGGKPRVIENAEGTRTTPSIVAYQDDGEILAGAPAKRQAVTNPKNTLYAVKRLIGRRFEEKEVQKDIGLMPYTITKADNGDAWVEVRGQKMAPPPNSAEVLRKMKKTAEDYLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKQEGDRKIAVYDLGGGTFDISIIEIAEIDGEHQFEVLSTNGDTFLGGEDFDNRLIDFLADEFKKEKRLDLRNDLLAKQRLKEAAEKAKIELSSAQQTEVNLPYITADATGPKHLVVKITRTKFESLVEDLIERSIKPCEVALKDAGVKPSDIQDVILVGGQTRMPKVQEKVKEFFGKEPRKDVNPDEAVAVGAAIQGGVLQGDVKDVLLLDVTPLSLGIETLGGVMTKLIKKNTTIPTKASQVFSTAEDNQNAVTIQVLQGEREMAAGNKSLGQFNLSDIPPAPRGMPQIEVTFDIDANAILHVSAKDKATGKENKITIKANSGLSEEEIKRMEEDAAAYADEDRKLRELVDARNSADGMVHSVKKSLSEHGDKLEAGEKEKIEAAIKDVEDAIKGDDKEAIEAKTNALMEASQKLGEKVYAEQQAQQGGAEEAQPQGEKTVDADVVDAEFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: R13L4_ARATH
Sequence: MVDAVVTVFLEKTLNILEEKGRTVSDYRKQLEDLQSELKYMQSFLKDAERQKRTNETLRTLVADLRELVYEAEDILVDCQLADGDDGNEQRSSNAWLSRLHPARVPLQYKKSKRLQEINERITKIKSQVEPYFEFITPSNVGRDNGTDRWSSPVYDHTQVVGLEGDKRKIKEWLFRSNDSQLLIMAFVGMGGLGKTTIAQEVFNDKEIEHRFERRIWVSVSQTFTEEQIMRSILRNLGDASVGDDIGTLLRKIQQYLLGKRYLIVMDDVWDKNLSWWDKIYQGLPRGQGGSVIVTTRSESVAKRVQARDDKTHRPELLSPDNSWLLFCNVAFAANDGTCERPELEDVGKEIVTKCKGLPLTIKAVGGLLLCKDHVYHEWRRIAEHFQDELRGNTSETDNVMSSLQLSYDELPSHLKSCILTLSLYPEDCVIPKQQLVHGWIGEGFVMWRNGRSATESGEDCFSGLTNRCLIEVVDKTYSGTIITCKIHDMVRDLVIDIAKKDSFSNPEGLNCRHLGISGNFDEKQIKVNHKLRGVVSTTKTGEVNKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPRSMEDLHNLQILDASYCQNLKQLQPCIVLFKKLLVLDMTNCGSLECFPKGIGSLVKLEVLLGFKPARSNNGCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCYDSYGDDLITKIDALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMSICSGNLVKMQEPFWGNENTHWRIEGLMLSSLSDLDMDWEVLQQSMPYLRTVTANWCPELESFAIEDVGFRGGVWMKTPLHRT
What is the function of this protein?
CC-NB-LRR receptor-like protein required for recognition of pathogenic bacteria type III effectors (T3E) such as Pseudomonas syringae HopZ1a and HopF2a and Xanthomonas campestris pv.  campestris (Xcc) XopAC/AvrAC; this recognition requires ZED1-related kinases (e. g.  PBL2, ZRK3 and ZED1/ZRK5) (PubMed:20368970, PubMed:26355215, PubMed:28288096, PubMed:30948527, PubMed:30948526, PubMed:28652264).  Confers allele-specific recognition and virulence attenuation of HopZ1a (PubMed:20368970).  Immunity mediated by RPP13L4/ZAR1 is independent of several genes required by other resistance protein signaling pathways such as NDR1 and RAR1 (PubMed:20368970).  Together with ZED1/ZRK5, involved in the regulation of the ambient temperature-sensitive intersection of growth and immune response in the absence of pathogens (PubMed:28499073).
What are the official names of this protein?
Disease resistance RPP13-like protein 4, Disease resistance protein ZAR1, Protein HOPZ-ACTIVATED RESISTANCE 1, AtZAR1.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family. RPP13 subfamily.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Note=Associates with the plasma membrane in the presence of the Xanthomonas campestris effector XopAC/AvrAC.
Protein: FBLN5_RAT
Sequence: MPGLKRILTVTILALWLPHPGNAQQQCTNGFDLDRQTGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTSYSGPYPAAAPPVPASNYPTISRPLVCRFGYQMDEGNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNDDGRSCQDVNECETENPCVQTCVNTYGSFICRCDPGYELEEDGIHCSDMDECSFSEFLCQHECVNQPGSYFCSCPPGYVLLEDNRSCQDINECEHRNHTCTPLQTCYNLQGGFKCIDPIVCEEPYLLIGDNRCMCPAENTGCRDQPFTILFRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
What is the function of this protein?
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN.  Stabilizes and organizes elastic fibers in the skin, lung and vasculature.  Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif.  Vascular ligand for integrin receptors which may play a role in vascular development and remodeling.  May act as an adapter that mediates the interaction between FBN1 and ELN.
What are the official names of this protein?
Fibulin-5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Embryonic vascular EGF repeat-containing protein, EVEC.
What is the protein family that this protein belongs to?
Belongs to the fibulin family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.
Protein: BPPCD_BOTFO
Sequence: QNWPHPPMPPAP
What is the function of this protein?
This peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it.  It acts as an indirect hypotensive agent (By similarity).
What are the official names of this protein?
Bradykinin-potentiating peptide 12d, BPP-12d.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-potentiating peptide family.
What are the subcellular locations of this protein?
Secreted.