PharMolix/UniProtQA huggingface dataset:
Protein: SKFA_BACSU
Sequence: MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRVCALPHPAMRAI
What is the function of this protein?
Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B. subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation (PubMed:12817086, PubMed:20805502).  Can also inhibit growth of other bacteria at high concentrations (PubMed:11851812).  Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344) (PubMed:20805502).  Has a role in protecting the secreted lipase LipA against proteolysis, either by modulating its folding or by acting as a protease inhibitor (PubMed:15812018).
What are the official names of this protein?
Sporulation killing factor, SKF, Sporulation-killing factor SkfA.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted by the ABC transporter SkfEF.
Protein: CYB_MACHA
Sequence: MAPNLRKSHPLLKMINNSLIDLPTPSNISAWWNFGSLLGICLMTQILTGLLLAMHYTADTTLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLYKETWNTGIILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGLTLIHLTFLHESGSNNPLGIVSNCDKIPFHPYFTLKDILGFTLMVLPLTSLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLSPFLHKAKQRTMTFRPLSQLLFWILVTNLFILTWVGSQPVEHPFIIIGQLASITYFTILLILFPIIGTLENKMLNF
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ACDH2_MYCUA
Sequence: MPSKASVAIVGSGNISTDLLYKLLRSDWLEPRWMVGIDPQSEGLARARKLGLETTHEGVDWLVAQSDKPDLVFEATSAYVHKAAAPKYAAAGIRAIDLTPAAVGPAVVPPANLREHLDAPNVNMITCGGQATIPIVYAVSRAVADLGGVPYAEIVASVASVSAGPGTRANIDEFTKTTSKGVETIGGARRGKAIIILNPADPPMIMRDTIFCAIPEDADRDAIAASIHEVVAQVQTYVPGYRLLNEPQFDEPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKETLAVSGGKR
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: CYB_FRETR
Sequence: MAPNLRKSHPLLKMVNNSLIDLPTPPNISAWWNFGSLLGICLTTQILTGLLLAMHYTADTTLAFSSVAHTCRNVQYGWLIRNIHANGASFFFICIYLHIGRGLYYGSYLYKETWNTGILLLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTIVEWAWGGFSVDNPTLTRFFALHFLLPFMIAGLTLIHLTFLHESGSNNPLGIVSNCDKIPFHPYFSLKDTLGFMLMLLPLTTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLSPLLHKSKQRTMAFRPLSQLLFWILIANLFILTWVGSQPVEHPFIIIGQLASLTYFTILLILLPITGALENKMLNY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LEXA_MYCBO
Sequence: MNDSNDTSVAGGAAGADSRVLSADSALTERQRTILDVIRASVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVNVRGADDAALPPVTEVAGSDALPEPTFAPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGTLFLLKVIGDSMVEAAICDGDWVVVRQQNVADNGDIVAAMIDGEATVKTFKRAGGQVWLMPHNPAFDPIPGNDATVLGKVVTVIRKV
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: UBE2W_MOUSE
Sequence: MASMQKRLQKELLALQNDPPPGMTLNEKSVQNSITQWIVDMEGAPGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGENIPIHPHVYSNGHICLSILTEDWSPALSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini (PubMed:21855799, PubMed:21229326).  Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3 (PubMed:21855799).  After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:21229326).  In vitro catalyzes 'Lys-11'-linked polyubiquitination.  UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i. e.  lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate (By similarity).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 W, E2 ubiquitin-conjugating enzyme W, N-terminal E2 ubiquitin-conjugating enzyme, N-terminus-conjugating E2, Ubiquitin carrier protein W, Ubiquitin-protein ligase W.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: TPSNR_PONAB
Sequence: MGTQEGWCLLLCLALSGAAETKPHPAERQWRAADVVLDCFLAKDGGHRAALASSEDRARASLVLKQVPVLDDGSLEDFTDFQGGTLAQDDPPIIFEASVDLVQIPQAEALLHADCSGKEVTCEISRYFLQMKGTTVETEAWFMANVQVSGGGPSISMVMKTPRDAKNEALWHPTLNLPLSPQGTVRTAVEFQVMTQTQSLSFLLGSSASLDCGFSMTPGLDLISVEWRLQHKGRGQLVYSWTTGQGQAVRKGATLEPEQLGMARNASLTLPSLTIQDEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLPTLICNIAGYYPLDVVVTWTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEPGSAGATYTCQVMHISLEEPLGASTQVVPPERRTALGVIFASSLFLLALLFLGLQRRQAPTRVGLLQAERWKTTSCADTQSSHLHEDRTACVSQPS
What is the function of this protein?
Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M.  Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).  Expression seems to slow down and down-regulate MHC class I surface expression.
What are the official names of this protein?
Tapasin-related protein, TAPASIN-R, TAP-binding protein-like, TAP-binding protein-related protein, TAPBP-R, Tapasin-like.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface.
Protein: THI6_SCHPO
Sequence: MKRQIDYSLYLVTSSSLIAPGSTIERQVEEGILGGVTLVQHREKDISTKCFVERAKRLSEICKKYDVPFLINDRIDVALAVGADGVHIGQDDMDCALARKILGDDAIIGVSTNNIEEIEKAAADGADYVGIGSIYETNTKDVKDRLIGITGLRKILEHVSKMHCQLGTVAIAGLNSSNIQRVIYLSEANGKRIDGIALVSAIMCSITPRETAKELRNLIATPPCFAQARSSLTTPKDLLNQIPAALQKLKDFTPLIHHLTNAVAKNFSANVTLAAYGSPTMGESYDEVADFAKAPGALVLNIGILENTKTYIHAAQVNNDLARPVILDPVAVGATTARSKVINTLLNYAYYDIIKGNEGEIMNLAGEQGLMRGVDSISQHTLAARITAVHRLAVERRCVVAMSGAVDVISDGNSTYVIKNGNPLLGQITASGCSLGSVMGVTASICQNDKLLAAITATLLYNIASELAVEAKNSCGDLLVQGPGTFIPIFVDKLHQLINETIKGNVDWIERAKLEKAE
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Probable thiamine biosynthetic bifunctional enzyme.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the Thz kinase family.
Protein: MPGP_ECOBW
Sequence: MFSIQQPLLVFSDLDGTLLDSHSYDWQPAAPWLTRLREANVPVILCSSKTSAEMLYLQKTLGLQGLPLIAENGAVIQLAEQWQEIDGFPRIISGISHGEISLVLNTLREKEHFKFTTFDDVDDATIAEWTGLSRSQAALTQLHEASVTLIWRDSDERMAQFTARLNELGLQFMQGARFWHVLDASAGKDQAANWIIATYQQLSGKRPTTLGLGDGPNDAPLLEVMDYAVIVKGLNREGVHLHDEDPARVWRTQREGPEGWREGLDHFFSAR
What are the official names of this protein?
Mannosyl-3-phosphoglycerate phosphatase, MPGP.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MPGP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCP_CUPPJ
Sequence: MRTVLLTGFEPFENEPINPSWEAVRALDGERIGDAVVVARQLPCVFGAAIDGMAALLRELKPAIAIAVGQAGGRTEMSVERVAINVDDARIADNAGAQPIDTVIAAKGPAAYFSTLPIKAIVRDMRAAGVPAAVSQTAGTFVCNHVFYGLMHALATPAGEGVRGGFIHIPYLPEQAARHPGEASMSLESMVRGIRQAIATTLATEVDVREQGGQLH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARB_SALTY
Sequence: MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAEDRRRFDIAMKKIGLDTARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGTGGGIAYNREEFEEICERGLDLSPTNELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALRGLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIADAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVGITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQYDLHPVYKRVDTCAAEFATDTAYMYSTYEDECEANPSIDRDKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQHAVDRLKLKQPANATVTAIEQAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQTAVSVSNDAPVLLDRFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKDNEVYLIEVNPRAARTVPFVSKATGVPLAKVAARVMAGKSLTEQGVTQEIIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKQGRALLSVREGDKERVVDLAAKLLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTAGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATTMALNADATEKVTSVQEMHAQIKKS
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: CRTZ_PARSN
Sequence: MTNFLIVVATVLVMELTAYSVHRWIMHGPLGWGWHKSHHEEHDHALEKNDLYGLVFAVIATVLFTVGWIWAPVLWWIALGMTVYGLIYFVLHDGLVHQRWPFRYIPRKGYARRLYQAHRLHHAVEGRDHCVSFGFIYAPPVDKLKQDLKMSGVLRAEAQERT
What is the function of this protein?
Catalyzes the hydroxylation reaction from beta-carotene to zeaxanthin via beta-cryptoxanthin.
What are the official names of this protein?
Beta-carotene hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
Protein: GRIA3_MOUSE
Sequence: MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
What is the function of this protein?
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission.  L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.  Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.  The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.  In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
What are the official names of this protein?
Glutamate receptor 3, GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi- pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression.
Protein: LPXH_PSEE4
Sequence: MILLISDLHLQEERPDITRAFLDLLDGRARHAKALYILGDFFEAWIGDDAMTPFQRSICQALRQLSDSGTTIYLMHGNRDFLIGQAFCQAAGCTLLDDPSVIELGGEAVLLMHGDTLCTRDVGYMKLRRYLRNPLSLWILRHLPLSTRQKLARKLRSESKSQTRMKNTEIVDVTPDEVPKVMAAHGVRTLVHGHTHRPAIHKLVIDGQPARRIVLGDWDRRGWALQVDEQGFQLAPFEFS
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HEG1_HUMAN
Sequence: MASPRASRWPPPLLLLLLPLLLLPPAAPGTRDPPPSPARRALSLAPLAGAGLELQLERRPEREPPPTPPRERRGPATPGPSYRAPEPGAATQRGPSGRAPRGGSADAAWKHWPESNTEAHVENITFYQNQEDFSTVSSKEGVMVQTSGKSHAASDAPENLTLLAETADARGRSGSSSRTNFTILPVGYSLEIATALTSQSGNLASESLHLPSSSSEFDERIAAFQTKSGTASEMGTERAMGLSEEWTVHSQEATTSAWSPSFLPALEMGELTTPSRKRNSSGPDLSWLHFYRTAASSPLLDLSSSSESTEKLNNSTGLQSSSVSQTKTMHVATVFTDGGPRTLRSLTVSLGPVSKTEGFPKDSRIATTSSSVLLSPSAVESRRNSRVTGNPGDEEFIEPSTENEFGLTSLRWQNDSPTFGEHQLASSSEVQNGSPMSQTETVSRSVAPMRGGEITAHWLLTNSTTSADVTGSSASYPEGVNASVLTQFSDSTVQSGGSHTALGDRSYSESSSTSSSESLNSSAPRGERSIAGISYGQVRGTAIEQRTSSDHTDHTYLSSTFTKGERALLSITDNSSSSDIVESSTSYIKISNSSHSEYSSFFHAQTERSNISSYDGEYAQPSTESPVLHTSNLPSYTPTINMPNTSVVLDTDAEFVSDSSSSSSSSSSSSSSGPPLPLPSVSQSHHLFSSILPSTRASVHLLKSTSDASTPWSSSPSPLPVSLTTSTSAPLSVSQTTLPQSSSTPVLPRARETPVTSFQTSTMTSFMTMLHSSQTADLKSQSTPHQEKVITESKSPSLVSLPTESTKAVTTNSPLPPSLTESSTEQTLPATSTNLAQMSPTFTTTILKTSQPLMTTPGTLSSTASLVTGPIAVQTTAGKQLSLTHPEILVPQISTEGGISTERNRVIVDATTGLIPLTSVPTSAKEMTTKLGVTAEYSPASRSLGTSPSPQTTVVSTAEDLAPKSATFAVQSSTQSPTTVSSSASVNSCAVNPCLHNGECVADNTSRGYHCRCPPSWQGDDCSVDVNECLSNPCPSTAMCNNTQGSFICKCPVGYQLEKGICNLVRTFVTEFKLKRTFLNTTVEKHSDLQEVENEITKTLNMCFSALPSYIRSTVHASRESNAVVISLQTTFSLASNVTLFDLADRMQKCVNSCKSSAEVCQLLGSQRRIFRAGSLCKRKSPECDKDTSICTDLDGVALCQCKSGYFQFNKMDHSCRACEDGYRLENETCMSCPFGLGGLNCGNPYQLITVVIAAAGGGLLLILGIALIVTCCRKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTDVYYSPTSVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDYF
What is the function of this protein?
Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity.  May act through the stabilization of endothelial cell junctions.
What are the official names of this protein?
Protein HEG homolog 1.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single- pass type I membrane protein. Cell junction. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: GPMB_SALTY
Sequence: MLQVYLVRHGETQWNAERRIQGQSDSPLTAKGEQQAMQVGERARSLGITHIISSDLGRTKRTAEIIAQACGCDITFDSRLRELDMGVLEKRQIDSLTEEEEGWRRQLVNGTQDGRIPGGESMQELSDRVHAALASCLELPQGSRPLLVSHGIALGCLVSTILGLPAWAERRLRLRNCSISRIDYQESQWLASGWVVETAGDVSHLDAPALDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.
Protein: CAIF_ECOLI
Sequence: MCEGYVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTEISCEVKMIPNKLEGRGCQCQRLVKVVDIDEQIYARLRNNSREKLVGVRKTPRIPAVPLTELNREQKWQMMLSKSMRR
What is the function of this protein?
Potential transcriptional activator of carnitine metabolism.
What are the official names of this protein?
Transcriptional activatory protein CaiF.
Protein: GLNE_HAEDU
Sequence: MFSQLDFTGLPLANTGENRPLAIAVAMSNFVKKTLQKQADLRDDWQRKLPTLADCGNYAERLTIYLSTINDEVQLSHCLRNFRHREMARLSFIQSNKLATVEFVFEQLSDLAEAIILAARDWLFTRCCAEYGTPVNGLGEIQPLLIIGMGKLGGRELNFSSDIDLIFTYPEAGQTVGGHKTIENSKFFTRLGQRLIKALDEITVDGFVYRTDMRLRPFGDNGALVLSFAAMEDYYQEQGRDWERYAMIKAKILGEDLTDVNHRYLQQMLRPFVYRRYLDFSAIQSLREMKQKISREVLRRNLQDNIKLGAGGIREIEFIVQTFQMIRGGRDKILQQRSLLQVLPHLVTLNLLTKQQAKHLGDAYIFHRQLENVLQAIDDQQTQSLPADAKNQARIMYACQSYWQKDQQNQPLMIEYHWQSWQQFLSTLAQHQQHVRVIFNQLIGEEEQANQSPVNEQLAIWQDILHPEIRQLELAEVLRDYPVATEDYATIFHLLANTLQDWSKRPIGVRGRKVLSQLMPKVMHSICSKTDYLVVLPRLLNIIDRVTTRTTYLELLQEKDQILPLLERLCGHSIMVAEQIARYPMLLDEFIINKSLMKVIEFEQYKTELTEYLIRIPEEDEEALIDALRQFKQGHLLRIAVADILGVLPVMKISDHLTYLAAAIISEVVNMAWKSLVKRFGKPTHLAEDERGFAVIAYGKLGGLELGYNSDLDLVFLHNAPLEGETSGRRSISNHQFYLKLAQKINSIFNLNTSAGVLYEVDMRLRPSGDAGLLVSTFQAYQYYQQHEAWTWETQALVRGRCVYGSASLIDEFSRIRRTTLCLARTRGRLRQEISQMRHKMYQHLTKTSTGQFNLKTDQGGITDIEFIAQSIVLEYAHCYPEMAKWSDNVRIFTAAIECGILSQHIGEGLKNAYTRIRNRIHQLNLLQLPSIVNDTEFVSERAFVTKIWQQIFTDNE
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: PRP5_YARLI
Sequence: MPRDREYDQWGYSGTRRDGGGRYGYRDRSRDERDRFRDVRDRDRDRDRDRERDRGGYRQDPRDRRYSRSRERERRGSGSRDRSRDRSRDRSRDAHRPPPSGRPHQPSGHDSTKSSNSMSETSSTSQVTGTTPNTTNATPSQAEIDAKKAAKLAKVAEWKRKKELERSKSASASPAPSTAPASPKAGFSMSGLSGLRKATDQGQVKRKMFFGGDSDEEDAGRKPAKLLKKLGEKEGSGKSEGKGRGGSQSEAKNASEKNGAASEPAEVDPLDAYMSSLTLPTTTSVSIADSTPLENLNVWEQVDTLEKSQDPTLDLSALSKRKEIAIVDHSKQVYEDFRRQFYVESSELADMTEAETNELRLSLDGIKIRGKDCPKPISKWTQLGLPGPTMGVLNDLRYDKPTSIQAQAIPAVMSGRDVISVAKTGSGKTLAFLLPMLRHIKHRVGVETHTTTLSGASSHPLGVIITPTRELCVQIYRDLRPFLAALELTAVCAYGGSPIKDQIAALKKGTHIIVCTPGRMIDLLAANQGRVLSLSRVTFLVIDEADRMFDMGFEPQVLKLTQSIRPDRQTVLFSATFPKKMEQLARRVLSKRSSDSLGPIEIIVGARSVVASEITQFVEVFQNEKSKFPRLLEVLGKYFAQGFFDEQSEGRVGTGESAATPIPNPKCLIFVERQESADSLLKELIQSGYPCLSIHGGKEQADRDQAISDFKSGLVSVLIATSVAARGLDVKGLGLVVNWDSPNHMEDYVHRVGRTGRAGQKGTALTFLLSDQERLAAEISRAIKSSGNAPPAPVQLMTERFEFKVRSGTEKRHMYGFSGKGLERLQDERDATREHERRAYEGDEAGEAETESSTPAASTANTDIIPKPVIVVTPPDSKSPTTAYHTTLQINDFPQQARYRASSNTSVSRVIANTGCSITAKGEYYPPGRIPGPKDEPKLFILIEGTSERAVKLAHHELSELLVSGLVKGARYQV
What is the function of this protein?
ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing.  Catalyzes an ATP-dependent conformational change of U2 snRNP.  Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
What are the official names of this protein?
Pre-mRNA-processing ATP-dependent RNA helicase PRP5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROD_ALKOO
Sequence: MKKVVKVKDITIGEGMPKICIPILGETLEEIKEEAELLSTFDFDIVEWRADFFQFVEDMDCIKLAMEIIEENLGDKPMIFTLRSLKEGGKREVCEALYFEINRRVLETKNLDILDIELFHDKDEIESLINLAHKNGAKVIISNHDFQQTPSKDEILSRMNRAAQLGADIVKIAVMANDTEDVITVLDATRILKEDYLKIPLIAIAMGKKGMITRFAGEIFGSDITFATAKKTSAPGQLSVEDVKNIVQFIHKHTI
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: TRNH8_ARATH
Sequence: MDKRWSLQGMTALVTGAASGIGYAIVEELASFGAIIHICDISETLLSQSLSEWEKKGFQVSGSICDVASRPDREKLMQTVSSLFDGKLNILVNNVGVIRGKPTTEYVAEDFSYHISTNLEPAFHFSQLSHLLLKASGFGSIVFMSSATGVVSVQCGSIYSLTKGALNQLTRNLACEWAKDGIRANAVAPNVVKTPLSQSYLEDVGFKEALFSRTPLGRAGEPNEVASLVVFLCLPAASYITGQTICIDGGFTVNAFSYKPQA
What are the official names of this protein?
Tropinone reductase homolog At2g29310.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. SDR65C subfamily.
Protein: LOLB_YERPY
Sequence: MPMRKRHFYRLLPLASLLLAACTIPVSKGPATSPTSPQWRQHEQQLQQLGQFETRGAFAYLSDKQKVYARFFWQQTSPERYRLLLTNPLGSTELELVVQPGVTQLTDNQGKHYVSDDPQEMIQKLTGMSIPLESLRQWILGLPGDTPNFTLDDKYRLKKLTYQQNGVTWVVDYQEYNTQVTPPLPSRLELNQDGQRIKLKMDSWTIK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: CSM3_ASPFU
Sequence: MENEGTLQDDRPASPKHAGDLFDYDFALDELWQETPNMPNNGAPMQASARDESGLGLGLDEEVKVTKKRQPVAKLDESRLLSQPGIPKLRRTAKKKLRFKGKGHEFSDAARLLNFYQLWLDDLFPRAKFADGLAIIERLGHSKRLQAMRKEWIDEEKPKDASENHNDVLKASESSGSQSDDPVVAFGGLNMADTKRSKGDIAGDYTSDAERMRVEVNLNPSGQRKLDEGLFMTDNDDVAQQPDNLGAPDDDELDALLKEQELLLMNNASA
What is the function of this protein?
Forms a fork protection complex (FPC) with tof1 and which is required for chromosome segregation during meiosis and DNA damage repair.  FPC coordinates leading and lagging strand synthesis and moves with the replication fork.  FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
What are the official names of this protein?
Chromosome segregation in meiosis protein 3.
What is the protein family that this protein belongs to?
Belongs to the CSM3 family.
What are the subcellular locations of this protein?
Nucleus.