PharMolix/UniProtQA huggingface dataset:
Protein: B1N_SICPE
Sequence: MGHMVNDLKLVDEFLNDGANSLELDVEFSSRGTAQRTHHGIPCDCFRYCTNSEKFSTYLDYIRQLTTPGNSKFRSRLILLVMDLKLNSLSNRAAYYAGADVALNLLNHYWQRGESEARAYIVLSLSTIGRADFISGFKNTMEKEGFADKYYDKIGWDFSGNENLQLIGNIFKIYGIREHIWQGDGITNCWIRGDSRLKEALNLRYSPSYVYADKVYTWSIDKESSIENALRLGVDGVMTNHPDRVIRVLGEKDFPNKFRLATYDDNPWEK
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SpeSicTox-betaIB4, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UVRB_DESVM
Sequence: MTQSPFILRTDYEPRGDQPEAIGQIVSNIEAGVTDQVLLGVTGSGKTFTMAQVIARCGRPALVLAPNKTLAAQLYNEFRQLFPENAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSINDNIDKLRHAATHALLTRRDVVIVASVSCIYGLGSPEYYAKLVIPVETGQRLSMDALITRLVEVQYERNDYDFHRGTFRVRGDVLEIIPAYHHERALRIEFFGDDIDAISEIDPLTGQVLASVGKTVIYPASHYVSDRDNLVRAISDIRDELGERLRELKGGNRLVEAQRLEQRTMLDLEMMEEMGYCNGVENYSRHLDGRKAGDPPSCLLDYFPDDFLLFVDESHITVSQVGAMYKGDRSRKSTLVDYGFRLPSALDNRPLEFHEFLARLNQAIYVSATPGKWELDRSQGIVAEQIIRPTGLVDPITEVRPTKGQVDDLLGECRLRAARDERVLVTTLTKRMAEDLTEYFNEMGVAARYLHSDIDTMERMAIIQALRRKEFDVLVGINLLREGLDIPEVSLVSILDADKEGFLRSAGSLIQTFGRAARNVEGRVLMYADVVTRSMQAAMDETARRRERQTGYNEAHHIVPATIRKAVETPFDAIYAEAAEAKGRKGKGRKGAAQAAETFAPWSSDPHELAKQIQQLERDMREAAKELEFERAAELRDRIRLLREHLLGAGGAG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QOX1_STAA8
Sequence: MNFPWDQLLVKGNWMITMAQIGAPFLVIGLIAVITYFKLWKYLYKEWFTSVDHKKIGIMYLICAVLMFVRGGIDALLIRAQLTVPDNKFLESNHYNEIFSTHGVIMIIFMAMPFIFGLWNIVVPLQIGARDVAFPVLNNVSFWLFFAGMILFNLSFIIGGSPAAGWTNYAPLAGEFSPGPGVNYYLIAIQISGLGTLATGINFFVTILRCKTPTMKFMQMPMFTVTTFITTLIVILAFPPLTVALALMTTDRIFDTAFFTVAHGGMPMLWANFFWVWGHPEVYIVILPAFGIYSEIIPTFARKRLFGHQSMVWATAGIAFLSFLVWVHHFFTMGNGALINSFFSISTMLIGIPTGVKLFNWLLTLYKGRITFESPMLFSLAFIPNFLLGGVTGVMLAMASADYQYHNTYFLVAHFHYTLVTGVVFACLAGLIFWYPKMMGYKLNETLNKWCFWFFMIGFNVCFLPQFILGLDGMPRRLYTYMPSDGWFLLNLISTIGALLMAIGFLFLVVSIVYSHFKSPREATGDNWDGLGRTLEWTTASAIPPKYNFAITPDWNDYDTFVDMKEHGRHYLDNHNYKDIHMPNNTPVGFWIGIFMTIGGFFLIFETVIPALICLFGIFGTMIYRSFQIDHGYHIPAAEVAETEARLREARIKEREAVSHES
What is the function of this protein?
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
What are the official names of this protein?
Probable quinol oxidase subunit 1, Quinol oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PARB_RICPR
Sequence: MVKNKGLGRGLSSLLGEEVLPIESEIVQIINIDKIKPNENQPRKHFEYNKIKELADSILNNGLLQPIIIDNNFQIIVGERRWRACKLAKVLEIPVIIKNFDTRESMEVALIENIQRTDLTVMEEARGFKYLVENFNYTVEKLAERLGKSRSHIANLLRLNNLPQSIQDKLNENILSMGHARCLINHEYAEEIADHIINHDLNVRQTEALVRQWHKNEYKKSSNNNNKVDKLCVKDNVIDNDLELLVKALSKKFGIKITIDNCRLGGKLMFHYKNLEELDLILSKLN
What is the function of this protein?
Involved in chromosome partition.  Localize to both poles of the predivisional cell following completion of DNA replication.  Binds to the DNA origin of replication (By similarity).
What are the official names of this protein?
Probable chromosome-partitioning protein ParB.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
Protein: RPOA_NITEC
Sequence: MSSNSFLTPRIIEVHNLSPLRAKVVMEPFERGFGYTLGNALRRVLLSSIPGCAPTKISISGVVHEYSTIDGLQEDIVDLILNLKGVVLKLHSKNSTVLSLKKDTEGIVTAGDIESSHDVEIVNPEHVIAHITSGGRIEAQITVEKGRGYLPSVNRSREDKSLSSIGDILLDASFSPVRRVSYTIENARVEQRTDLDKLIIDIETNGSVDPEEAIRYAARVLVEQFSFFADLESTLLPTEQPRAPAIDPILLRPVDDLELTVRSANCLKVENIFYIGDLIQRTEAELLRTPNLGRKSLNEIKEVLASRDLSLGMKLENWPPANLENYVKEPGHASS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: NHAP2_YERPB
Sequence: MDAITINSLFLVGAVLVAASILLSSFSSRLGIPILVIFLAIGMLAGTDGLGGIAFDNYPAAYLVSNLALAVILLDGGMRTRASSFRVALWPALSLATFGVIITAGLTGLVAAWLFNLDIIQGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMAVFLTVTLIAMIAAGETSLSWMFLVHLIQQFGLGIIIGLLGGGLLLLLINRMELANGLYPLLAVSGGILVFALVTALNGSGILAVYLCGLLLGNRPIRNRAGILQTFDGLAWLSQIGMFLVLGLLLNPSDLLPIAIPALLLSLWMILFARPLSVFIGLLPFRSFNLRERVFISWVGLRGAVPVILAVFPMMAGLPNANLFFNVAFFVVLVSLLLQGTTLSFAARKAKLVVPPTLAPVSRIGLDIDMNNQWEQFIYQLSCDKWCIGATLRDLKMPQGTRIAALFRGKDLLHPTGSTRLKEGDILCVIGQEHDLPALGKLFSQSPNIQLDERFFGDFILDADAKLQDISQIYGLNLEPTVDKQQTLGQFVLYLFGGEPVIGDQIEWDGLTWTIAEMESDRVSRVGVKIVTDKA
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: B3GN2_HUMAN
Sequence: MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIPKEKFWKISTPPEAYWNREQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAGPHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC
What is the function of this protein?
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine.  Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains.  Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646).  Probably constitutes the main polylactosamine synthase.
What are the official names of this protein?
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, Beta-1,3-N-acetylglucosaminyltransferase 1, BGnT-1, Beta-1,3-Gn-T1, Beta3Gn-T1, Beta-1,3-galactosyltransferase 7, Beta-1,3-GalTase 7, Beta3Gal-T7, Beta3GalT7, b3Gal-T7, Beta-3-Gx-T7, UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2, BGnT-2, Beta-1,3-Gn-T2, Beta-1,3-N-acetylglucosaminyltransferase 2, Beta3Gn-T2, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: RSMG_PAEAT
Sequence: MVEITAAELEAAEKIFGERLDLAKRYVEHLATSGTERGLIGPREIPRLWSRHVLNCAVIESAIAMDSHVADVGSGAGLPGLCLAIARPDLELTLIEPLERRVIWLQEVVDDLGLDNVTIMRTRAELAVGMVDADVVTARAVSALSNLAGLTIPLLNGHGEVVAIKGRSAAEEIEKAKKVIRKLGGVETSVVVCGQELLEEPTTVVRIIVNKPGKTA
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MET_MOUSE
Sequence: MKAPTVLAPGILVLLLSLVQRSHGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHGHHIYLGATNYIYVLNDKDLQKVSEFKTGPVLEHPDCLPCRDCSSKANSSGGVWKDNINMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNSADIQSEVHCMFSPEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPGYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFLDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPSDDILFGVFAQSKPDSAEPVNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARSDEYRTEFTTALQRVDLFMGRLNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHLTPHVNFLLDSHPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLNGLGCGHFQSCSQCLSAPYFIQCGWCHNQCVRFDECPSGTWTQEICLPAVYKVFPTSAPLEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIISNSRETTQYSAFSYVDPVITSISPRYGPQAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTSDEFPVKLKIDLANRETSSFSYREDPVVYEIHPTKSFISGGSTITGIGKTLNSVSLPKLVIDVHEVGVNYTVACQHRSNSEIICCTTPSLKQLGLQLPLKTKAFFLLDGILSKHFDLTYVHNPVFEPFEKPVMISMGNENVVEIKGNNIDPEAVKGEVLKVGNQSCESLHWHSGAVLCTVPSDLLKLNSELNIEWKQAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLLSGLFLWMRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYVNVKCVAPYPSLLPSQDNIDGEGNT
What is the function of this protein?
(Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells.
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: Y304_ENCCU
Sequence: MNTTHVPEPHRTEQHTENLQHWRKILGIAPIVSIAFPAIMYFIFTKDSFEDSLFLRFITILLSFSYSAVQYAVLLHTNWKSHNKPEGILHTTLYYTLNLLLLAFSIISILSITTLPINKWKNDGGPILFSIFLPPLFMSPAYLLSTSCRLVPGQIGFTDTGINVLIDILTLLCSVGSLLLILEESEYCYCFAIISSILILIRLLGEKLSPEKQSPPPTAPWRIAVFVLILIFAALIYAFMMWVSIDILSDHFDLLTKARSTSVSKPGQ
What are the official names of this protein?
UPF0328 protein ECU03_0040.
What is the protein family that this protein belongs to?
Belongs to the UPF0328 family.
Protein: PAND_FRAAA
Sequence: MLRTMLTAKIHRATVTQADLHYVGSVTIDADLLEAADLLPGEQVTIVDINNGARLETYAIAGPAGSGVIGINGAAARLVQPGDLVIIIAYGMMDDAEARRHVPRVLFVDAENRIIGRGHDPAEALPDDPSSLRGDLAVPGNPVTAAARRGTPTHQAPVALPASRTVVAPR
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_THETH
Sequence: MEGMRRPTPTVYVGRVPIGGAHPIAVQSMTNTPTRDVEATTAQVLELHRAGSEIVRLTVNDEEAAKAVPEIKRRLLAEGVEVPLVGDFHFNGHLLLRKYPKMAEALDKFRINPGTLGRGRHKDEHFAEMIRIAMDLGKPVRIGANWGSLDPALLTELMDRNASRPEPKSAHEVVLEALVESAVRAYEAALEMGLGEDKLVLSAKVSKARDLVWVYRELARRTQAPLHLGLTEAGMGVKGIVASAAALAPLLLEGIGDTIRVSLTPSPKEPRTKEVEVAQEILQALGLRAFAPEVTSCPGCGRTTSTFFQELAEEVSRRLKERLPEWRARYPGVEELKVAVMGCVVNGPGESKHAHIGISLPGAGEEPKAPVYADGKLLTILKGEGIAEEFLRLVEDYVKTRFAPKA
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: P2RX2_RAT
Sequence: MVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEDKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHSDDDCIAGQLDMQGNGIRTGHCVPYYHGDSKTCEVSAWCPVEDGTSDNHFLGKMAPNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEKAGENFTELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPKHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSPPSGEGPTLGEGAELPLAVQSPRPCSISALTEQVVDTLGQHMGQRPPVPEPSQQDSTSTDPKGLAQL
What is the function of this protein?
Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis.  In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling.  Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).
What are the official names of this protein?
P2X purinoceptor 2, P2X2, ATP receptor, Purinergic receptor.
What is the protein family that this protein belongs to?
Belongs to the P2X receptor family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ENGB_NEIGO
Sequence: MNLFQNAKFFTTVNHLKDLPDTPLEIAFVGRSNAGKSSAINTLTNHVRLAYVSKTPGRTQHINFFELQNGNFMVDLPGYGYAQVPEAVRAHWVNLLGDYLRHRKELIGLVLIMDARHPLKELDIRMLDFFHTTGRPVHILLSKADKLSKNEQIKTLSQVKKLLKPYSDRQNISVQLFSSLKKQGIDEANRTVGSWFDAADAAASSPEEN
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: ADT1_SOLTU
Sequence: MADMNQHPTVFQKAANQLDLRSSLSQDVHARYGGVQPAIYQRHFAYGNYSNAGLQRGQATQDLSLITSNASPVFVQAPQEKGFAAFATDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKAGRLSEPYKGIGECFGRTIKEEGFGSLWRGNTANVIRYFPTQALNFAFKDYFKRLFNFKKDRDGYWKWFAGNLASGGAAGASSLFFVYSLDYARTRLANDRKASKKGGERQFNGLVDVYKKTLKSDGIAGLYRGFNISCVGIIVYRGLYFGMYDSLKPVLLTGNLQDSFFASFGLGWLITNGAGLASYPIDTVRRRMMMTSGEAVKYKSSLDAFSQIVKNEGPKSLFKGAGANILRAVAGAGVLAGYDKLQVLVLGKKFGSGGA
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
What are the official names of this protein?
ADP,ATP carrier protein, mitochondrial, ADP/ATP translocase, Adenine nucleotide translocator, ANT.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TEPP_HUMAN
Sequence: MGIVCAQCSFILLLSIIRARPPPFLFCPLSSQRTESPYKPVHLGLGPTDKVAAIAMARIIDLVPWDDGSTHVYASPAILLPMERQRNQLAGVKQQLYHPALPTLRHMDRDTVKACLPDEHCQSTTYCRKDEFDNAHFTLLGVPNKPLQCLDITATGQKLRNRYHEGKLAPIAPGINRVDWPCFTRAIEDWSHFVSSAGEFKLPCLRKRAEGLSGYAVRYLKPDVTQTWRYCLSQNPSLDRYGQKPLPFDSLNTFRSFGSSYSRVNYLTPWH
What are the official names of this protein?
Testis, prostate and placenta-expressed protein.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPF_TETOB
Sequence: MSFSFLFLGNLPLAEGFGINTNIFETNIINLAAVVAIVISFVGKNLSALLEDRRKTIVNNLQEASQRAAEAQERLNIAKNQLEVAKKKATEIREEGVFRATQEINNCVAQHEERLSKLEEFKQETVQFYQQKAFKQAYVYIISRIMSRVKERLNKGLDATYHVVVNNFYVSRFTEYNP
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PTKB_ECOL6
Sequence: MKRKIIVACGGAVATSTMAAEEIKELCQSHNIPVELIQCRVNEIETYMDGVHLICTTARVDRSFGDIPLVHGMPFVSGVGIEALQNKILTILQG
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.  The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport.
What are the official names of this protein?
PTS system galactitol-specific EIIB component, EIIB-Gat, Galactitol-specific phosphotransferase enzyme IIB component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPE_SALTI
Sequence: MELLLLSNSTLPGKAWLEHALPLIANQLNGRRSAVFIPFAGVTQTWDEYTDKTAEVLAPLGINVTGIHRVADPLAAIEKAEIVIVGGGNTFQLLKESRERGLLAPVADRVKRGALYIGWSAGANLACPTIRTTNDMPIVDPNGFDALDLFPLQINPHFTNALPEGHKGETREQHIRELLVVAPELTVIGLPEGNWIQVSNGQAVLGGPNTTWVFKAGEEAVALEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBAR1_HUMAN
Sequence: MMRRTLENRNAQTKQLQTAVSNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINAYAATETPHLKLGLMNFADEFAKLQDYRQAEVERLEAKVVEPLKTYGTIVKMKRDDLKATLTARNREAKQLTQLERTRQRNPSDRHVISQAETELQRAAMDASRTSRHLEETINNFERQKMKDIKTIFSEFITIEMLFHGKALEVYTAAYQNIQNIDEDEDLEVFRNSLYAPDYSSRLDIVRANSKSPLQRSLSAKCVSGTGQVSTCRLRKDQQAEDDEDDELDVTEEENFLK
What is the function of this protein?
Acts as a positive regulator of ciliary hedgehog signaling (By similarity).  Probable regulator of ciliogenesis involved in limb morphogenesis (PubMed:27528616, PubMed:30395363).  In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616, PubMed:30395363).  Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (PubMed:30404948).  In vitro, can generate membrane curvature through preferential interaction with negatively charged phospholipids such as phosphatidylinositol 4,5-bisphosphate and cardiolipin and hence orchestrate cristae shape (PubMed:30404948).
What are the official names of this protein?
CBY1-interacting BAR domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the CIBAR family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Weak punctate vesicular distribution throughout the cytoplasm (PubMed:27528616). Localizes at the distal end of mother centrioles (PubMed:27528616). Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616). SUBCELLULAR LOCATION: [Isoform 3]: Nucleus.
Protein: RGAP1_ARATH
Sequence: MTEVLHFPSSPSASHSSSSSSSSPSPSSLSYASRSNATLLISSDHNRRNPVARFDQDVDFHASIEEQDLRRRSSTDGGEEDDGGEDQISLLALLVAIFRRSLISCKSNRRELCSMEIGWPTNVRHVAHVTFDRFNGFLGLPVEFEPEVPRRAPSASATVFGVSTESMQLSYDSRGNCVPTILLLMQNCLYSQGGLQAEGIFRLTAENSEEEAVREQLNRGFIPERIDVHCLAGLIKAWFRELPTSVLDSLSPEQVMQCQTEEENVELVRLLPPTEAALLDWAINLMADVVQYEHLNKMNSRNIAMVFAPNMTQMDDPLTALMYAVQVMNFLKTLIEKTLRERQDSVVEQAHAFPLEPSDESGHQSPSQSLAFNTSEQSEETQSDNIENAENQSSSSEISDELTLENNACEQRETDFGKYRTGRLSDSSQQVVLNLDPPAQWPVGRTKGLTNLSRVGSRVERTEAWR
What is the function of this protein?
Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state.
What are the official names of this protein?
Rho GTPase-activating protein 1, Rho-type GTPase-activating protein 1.
Protein: VP7_ROTB4
Sequence: MYGIEYTTILIFLTSITLLNYTLKSITRIMDYIIYRFLLIVAILATIMNAQNYGVNLPITGSMDTAYANSTQSEPFLTSTLCLYYPVEASNEMADTEWKDTLSQLFLTKGWPTGSVYFKEYTDIAAFSVEPQLYCDYNLVLMKYDSTQKLDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGSSCTVKVCPLNTQTLGIGCLITNPDTFETVATTEKLVITDVVDGVNHKLNVTTATCTIRNCKKLGPRENVAVIQVGGANILDITADPTTTPQTERMMRINWKKWWQVFYTVVDYVNQIIQTMSKRSRSLNSSAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: REX2_ENTFA
Sequence: MEKKMPKATAKRLPVYLRYLKMLGDSGVKRIKSREFSEMIQIPSATIRRDFSHVGELGRSGYGYDVPYLIEVFSNILNTQEEKRIALIGCGNLGKALLKNNFRRNENLNIVCAFDNDSALVGTTINGLLVHDMSELEAFVRQEGVTVAISTVPSHHAQKAIDKIVQAGVTAILNFAPDRVSVPANVSVQYIDLTTELQTLIYFNETFSLANSPKQ
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex 2.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.