PharMolix/UniProtQA huggingface dataset:
Protein: RL18_COXB2
Sequence: MDKQEKRIRRARRTRAKIKELGAVRLCVHRSLNHIYAQLISPRDSKVLVCASTLEKEVRSQIKHGGNIQAATAIGKLIAQRAKKAGVTKVAFDRSGYKYHGRVRALAEAVREGGIEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TAT_HV1B5
Sequence: MEPVDPRLEPWKHPGSQPKTACTTCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRA
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Tat seems to inhibit the HAT activity of KAT5/Tip60 and TAF1, and consequently modify the expression of specific cellular genes.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines (such as IL10) or cytokine receptors.  May be involved in the derepression of host interleukin IL2 expression.  Mediates the activation of cyclin-dependent kinases and dysregulation of microtubule network.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Host extracellular matrix metalloproteinase MMP1 cleaves Tat and decreases Tat's mediated neurotoxicity.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.  Binds to KDR/VEGFR-2.  All these Tat-mediated effects enhance angiogenesis in Kaposi's sarcoma lesions (By similarity).
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type (By similarity).
Protein: SYDP_SHIDS
Sequence: MDDLTAQALKEFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQSAIHTFYTTQFAGDIHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: TIG_ENTFA
Sequence: MSAKWEKKGTNDGVLTFSIEQAVIEKGLTQAFNKVKKNLNVPGFRKGKVSRTVFNRMYGEEALYEDALNAVLPEAYEAAVLEAGIEPVAQPKIDVESMNKGEDWVITAEVTVKPEVKLGEYKNLTVSKQDREVTDEDVEARLKREQESQAELVIKEDAAAENGDTVVIDFEGFLGDEAFEGGKGENYSLELGSNSFIPGFEDQLVGKKAGEEVEVNVTFPEDYQAEDLAGKEAVFKVTVHEVKAKELPELDDEFAKDVDDSVESLDELKEKFRKELTEAKEAAAEEAKDEEAIRLAVENAEIVELPHVMVHDEVHRSMDEFLNNMQRQGISPEMYYQLTGSTEEDLHKQFEGEAETRTKTNLVIEAVAKAENIEVTQEDIDAEVKDLAEQYNMPEAQVRKVLNNDMLEHDIRMKRAVETITETAVEK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: KCNC1_RAT
Sequence: MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT
What is the function of this protein?
Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons.  The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10482766, PubMed:14679187).  Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766, PubMed:14679187).  Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766).
What are the official names of this protein?
Potassium voltage-gated channel subfamily C member 1, NGK2, RAW2, Voltage-gated potassium channel subunit Kv3.1, Voltage-gated potassium channel subunit Kv4.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Presynaptic cell membrane. Note=Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones.
Protein: WSCD2_MOUSE
Sequence: MAKLWFKFQRCFRYFRRKPVRFFTLLAIYLTAGSLVFLHSGFVGQPAVPQSQASPAAGSPVEGAELPFLGDLHLGRGFRDTVEASSIARRYGPTFKGKDTSERAKLGDYGGAWSRALKGRVVREKEKEKEEEKAKYIGCYLDDTQSRALRGVSFFDYKKMTVFRCQDNCAERGYLYAGLEFGAECYCGHKIQAANVSESDCDMECKGERGSVCGGINRLSVYRLQLAQESARRYGSAVFRGCFRRPNNLSLALPVSAAMPNMSVDKCVDLCTEKEFPLAALAGTACHCGFPTTRFPLHDREDEQLCAQKCSAEEFESCGTPSYFIVYQTQVQDNRCMDRRFLPAKSKKLIALASFPGAGNTWARHLIELATGFYTGSYYFDGSLYNKGFKGERDHWRSGRTICIKTHESGQKEIEAFDAAILLIRNPYKALMAEFNRKYGGHIGFAAHAHWKGKEWPEFVRNYAPWWATHTLDWLKFGKTVLVVHFEDLKQDLFTQLGRMVSLLGVAVREDRLLCVESQKDGNFKRSGLRKLEYDPYTAEMRRTIAAYIRMVDTALRSRNLTGVPDAYGPR
What is the function of this protein?
Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
What are the official names of this protein?
Sialate:O-sulfotransferase 2, WSC domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the WSCD family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GVPO2_HALSA
Sequence: MDDPVADQPDGTDETPDGDTAGSSPIGLADAQARAREAVAELLEHPFDGIITAESGADGGWRILAEVVERSAVPDTQDIIGRYEITLDDGGRVTGYELRERYRRGEMKEEL
What are the official names of this protein?
Protein GvpO 2.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: HYPA_CAMJE
Sequence: MHELSIVESLIELCEENALNNKAYNVQEIYVKIGRLSGIEVDLFKRCFETFKENSNICKNAKLFIELAPLEILCLKCDQTSILEENVFKCPKCQSIEYKIIQGEDLHLMRLVMK
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: AROK_FRATT
Sequence: MIRTKNIFLIGPVGAGKSTIGKQLAKQLKLEFIDSDDVIEKKCGVDINWIFDLEGEEGFRKREREVIAEILAEKQNIVLATGGGAILDPETRSLLSSRGKVVYLEATIEQQLERTSKDTKRPLLRVDDKRPVLEQLMAEREPLYRSIADVVVETNGATVKNIVNKISTFLVEETIL
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSP_CERSK
Sequence: MSFTPTDYNAYDFANRRHIGPSPSEMEEMLRVVGVSSLDQLIEETVPASIRQETPLDWAPLAEHELLARMREVAAKNRVMTSLIGQGYYGTVTPPAIQRNILENPAWYTAYTPYQPEIAQGRLEALLNYQTMVADLTGLPVANASLLDEATAAAEAMTMAERASKSKARAFFVDADCHPQTISVIRTRAEPLGIEVIVGHPAQLVPEDVFGALFQYPGTYGLVRDFTRDIAALHEAKALAVVATDLLALCLLKEPGAMGADIAIGSSQRFGVPMGYGGPHAAFMSCKDDLKRSMPGRLVGVSVDARGNKAYRLALQTREQHIRREKATSNVCTAQALLAVMASFYAVFHGPRGLRAIAERVHLNTVRLATALKEAGARVSPEAFFDTITVEVGVGQAGILAAARHRGINLRKVGRDRVGISLDETTDAGVIARVLDAFGIHEPAPAKVGLGFPEPLLRETGYLSHPVFQMNRAESEMMRYMRRLSDRDLALDRAMIPLGSCTMKLNAAAEMMPITWPEFGTLHPFAPADQAAGYHEAIGDLAQRLCRITGYDAMSMQPNSGAQGEYAGLLTILAYHRARGDAERTICLIPVSAHGTNPASAQMAGMKVVVVKSAPNGDVDLEDFRDKAAAAGDRLAACMITYPSTHGVFEETVREVCRITHEHGGQVYIDGANMNAMVGLVQPGAIGGDVSHLNLHKTFAIPHGGGGPGMGPIGVKAHLAPYLPGHPEVTGPLTGGHDEAADEGPVSAAPYGSASILLISWAYCLMMGGEGLTQATRVAILNANYIAARLRGAYKVLFMGNRGRVAHECILDTRPFAEAGVTVDDIAKRLIDNGFHAPTMSWPVPGTLMVEPTESETKAEIDRFVAALLAIREEIRAVEEGEIAAADSPLRHAPHTVEDLVADWDRKYPREQGCFPPGSFRVDKYWPPVGRVDNAWGDRNLVCTCPPVESYSIAAQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: YNFB_ECOUT
Sequence: MKITLSKRIGLLAFLLPCALALSTTVHAETNKLVIESGDSAQSRQRAAMEKEQWNDTRNLRQKVNKRTEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVIIP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: MURB_VIBCH
Sequence: MQIQLGANLKPYHTFGIEQLAAQLVVAESIDDLKALYCSAEWASLPKLIIGKGSNMLFTCHYTGMIVVNRLNGIEHQQDDDYHRLHVAGGEDWPSLVSWCVEQGIGGLENLALIPGCAGSAPIQNIGAYGVEFKDVCDYVEYLCLETGTVKRLTMEECQFGYRDSIFKHQLYQKAVVTAVGLKFAKAWQPIIQYGPLKDLSSDCAIHDVYQRVCATRMEKLPDPAVMGNAGSFFKNPVISQQAFARLQIEHPDVVAYPAEQGVKVAAGWLIDQAGLKGHQIGGAKVHPKQALVIVNTGDASAQDVLMLAADIQQRVFNCYGIELEHEVRFIGESEETNLKQWMSEQA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_GEOSW
Sequence: MKAVGIIVEYNPFHNGHLYHLEETKKQTGADCIIAVMSGNFLQRGEPALVSKWARTKMALSAGVDIVIELPYAFAVQSAEQFASGAVTLLHSLFCEEICFGSENGNITAFIDAAKTFLEQKQQHDSYVQEALQEGVSYPRANAEAWKRLNATNLDLSKPNNVLGLAYVKAILQKQIPITPRTIRRIASDYHDKTFSHPSIASATSLRKALKGSLAHLETIAPYIPGTTKQTLEQYYDTYGMFHEWEAYFPFLKYRIMTAEEAELRQIAGVDEGIEHRLKQEIVAAPTFSAFMNSIKTKRYTWTRLQRICTHILTNFTKDQRKKTETPTYIRLLGMSSNGRRYLQHVKKHLPLPLVTKVSNLKHDPIYQQEKKASFAYAAIFPEPARTNVLKEEYATPPLLQ
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_WOLSU
Sequence: MKKAVILLNMGGPSSLLEVDMFLKNMFNDPRILPIKSPFFRSLVASFIANRRSETAKANYRKIGGKSPLIGHTFNLIQKLQSLDPSRFYTYAMRYTPPMTDMAVRELAQKEIEEVTLFSLYPQYSTTTTLSSIEEFHKQCALLSYFPKTKEIDRYFEDSNYNEAIIDRILEALGGDNPEEFTLIFSAHGLPQSVIDAGDPYEKEVHANIQALTKLLEERGITFKKITHAYQSKVGPMKWLEPSLDEVLKLHAKEKILLYPIAFTLDNSETDFELRIEYQEKATHLGITDYRVASCLNDSTRFAHAIIKLISQGEIS
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIN1_ARATH
Sequence: MGHRVLVYVGALFLILFTIFPSSSALISSPDANPPYPKAISDLKESIVKGLGFQSEEVKVSGFDIRDALVGHSVSYEFDLEIDNKVLPFKLLEDVNRWEYVDLPIFQVEQPSENGLVPMRNKKTSSDDVLPVLAPFQLSGPMELWIQDANNMRLSLPYDVDAGVLKKVILADGAVVTVKGARSVSLRHPIDLPLPLNQSSNEFASGLLSLAEQLRRASTDQESPVLSLRIVGPTSLASTSQSPDNKLKLKRLAPGLVELSSMSKDKRSLSTIGANAMTTVLTPREFTTMWPITSINGSNANLLGFEKLLTSVLGPKAQEKGSFKVLKAKVAAQTFMKIGFGIEKKLKEADVEGLSFPEWRTKPETMRMHFEVLAKVDGENVIPENVMRVDPIPLEDTIAQNVITGNVTMSKLPIIESPPSPFTL
What is the function of this protein?
Involved in the regulation of pollen surface morphology, probably by modulating the secretion of proteins and/or lipids during pollen development.
What are the official names of this protein?
Protein TUNICAMYCIN INDUCED 1.
Protein: CSMI_CHLTE
Sequence: MNLIINDKTASSSVGQTIGKAARLNHAHVGYVCGGHGLCQACYITVQEGADCLAPLTDVEKAFLSPRQIAAGGRIACQATIAKEGTVKVLSRPEEVRRMVFSNPFQLIGYAADMGKDTAQQIVPGVQNLIGRIQRGEMGGKDALGDMIESIQGAAGLVVEAIQQGPMALPIPFKEQIADLISKLPLPQIQLPSISLPQLPSISFPQLPFSLPKLPFSLPFLPQQPQATASLEKVTITVQPPAKD
What is the function of this protein?
Could play a direct role in the oxidation or reduction of the quenching species formed in the chlorosome.
What are the official names of this protein?
Chlorosome protein I.
What are the subcellular locations of this protein?
Chlorosome.
Protein: DDX51_HUMAN
Sequence: MALFYVARYPGPDAAAAAGPEGAEAGAHGRARALLERLQSRARERQQQREPAQTEAAASTEPATRRRRRPRRRRRVNDAEPGSPEAPQGKRRKADGEDAGAESNEEAPGEPSAGSSEEAPGEPSAGSSEEAPGERSTSASAEAAPDGPALEEAAGPLVPGLVLGGFGKRKAPKVQPFLPRWLAEPNCVRRNVTEDLVPIEDIPDVHPDLQKQLRAHGISSYFPVQAAVIPALLESAACGFLVGRGGYRPSDLCVSAPTGSGKTLAFVIPVVQALLSRVVCHIRALVVLPTKELAQQVSKVFNIYTDATPLRVSLVTGQKSLAKEQESLVQKTADGYRCLADIVVATPGRLVDHIDQTPGFSLQQLRFLIIDEADRMIDSMHQSWLPRVVAAAFQSEDPADPCALLQRRQAQAVTAASTCCPQMPLQKLLFSATLTQNPEKLQQLGLHQPRLFSTGLAHRGLEDTDGDGDSGKYAFPVGLTHHYVPCSLSSKPLVVLHLVLEMGFSRVLCFTNSRENSHRLFLLVQAFGGVDVAEFSSRYGPGQRRMILKQFEQGKIQLLISTDATARGIDVQGVELVVNYDAPQYLRTYVHRVGRTARAGKTGQAFTLLLKVQERRFLRMLTEAGAPELQRHELSSKLLQPLVPRYEEALSQLEESVKEERKQRAA
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.
What are the official names of this protein?
ATP-dependent RNA helicase DDX51, DEAD box protein 51.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: COXX_ROSDO
Sequence: MADVGYTSSPAAKEYEAQLGDYFALLKPRVMSLVVFTALVGLQAAPVSVHPVIGFASILFVAIGAGASGALNMWWDADIDAVMRRTANRPIPAGRVQPGEALNLGAALSGLSIMMLALTANFLAAGLLAFTIFFYAVIYSMWLKRWTPQNIVIGGAAGAFPPVIGWVIATGSLSIEAWLMFALIFMWTPPHFWALALFMKSDYDDAGVPMLTVTHGRKKTRAHIIAYTVLLAVLAVGTGFSAIGGPVYLAAALVLNALFLKGAIDIWRRDEDTAIADEYRVEKKFFRLSLWYLFAHFGAILLESALRPFGLGGW
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTNC_PSEAE
Sequence: MTIKAILTDIEGTTSAVSFVFDVLFPYAARHLPDFVREHAGETEVAAQLAAVRAESGEADADVERVIAILLQWIAEDRKATPLKALQGMVWAQGYRDGQLKGHVYPDAVQALREWKARGLDLYVYSSGSIQAQKLIFGCSEAGDLGSLFSGYFDTTSGPKRESASYARIAGAIGLPAAEILFLSDVVQELDAARDAGMRTLGLAREGGSLDGHPTVASSPTSSWSERAGYPEGTLLLGSIAPWVPPSAG
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: MEND_STAAW
Sequence: MGNHKAALTKQVFTFASELYAYGVREVVISPGSRSTPLALAFEAHPNIKTWIHPDERSAAFFAVGLIKGSERPVAILCTSGTAAANYTPAIAESQISRIPLIVLTSDRPHELRSVGAPQAINQVNMFNNYVSYEFDMPIADDSKETINAIYYQMQIASQYLYGPHKGPIHFNLPFRDPLTPDLNATELLTSEMKILPHYQKSIDASALRHILNKKKGLIIVGDMQHQEVDQILTYSTIYDLPILADPLSHLRKFDHPNVICTYDLLFRSGLDLNVDFVIRVGKPVISKKLNQWLKKTDAFQILVQNNDKIDVFPIAPDISYEISANDFFRSLMEDTTINRVSWLEKWQRLEKKGRKEIKCYLEQATDESAFVGELIKKTSEKDALFISNSMPIRDVDNLLLNKNIDVYANRGANGIDGIVSTALGMAVHKRITLLIGDLSFYHDMNGLLMSKLNNIQMNIVLLNNDGGGIFSYLPQKESATDYFERLFGTPTGLDFEYTAKLYQFDFKRFNSVSEFKNATLLSETSTIYELITNREDNFKQHQILYQKLSEMIHGTL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: UBIA_BURVG
Sequence: MLARFPLYLRLVRMDKPIGSLLLLWPTLNALWIASDGRPRWPLVAIFALGTLLMRSAGCAMNDYADRDFDRHVKRTADRPLTSGKIRAWEAVAIAAVLSFVAFLLILPLNTLTKELSVVALFVAGSYPFMKRFFAIPQAYLGIAFGFGIPMAFAAVQGTVPALAWVMLVANVFWSVAYDTEYAMVDRDDDIKIGIRTSALTFGRFDVAAIMLCYAVTLGIYAWIGATLGFGLAFWAGWAAALGCALYHYTLIKDRERMPCFAAFRHNNWLGGVLFAGIAAHYLVAGAAGN
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GNAS_MESAU
Sequence: MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).  Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP.  GNAS functions downstream of several GPCRs, including beta-adrenergic receptors.  Stimulates the Ras signaling pathway via RAPGEF2.
What are the official names of this protein?
Guanine nucleotide-binding protein G(s) subunit alpha, Adenylate cyclase-stimulating G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(s) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: TX19A_ODOMO
Sequence: MKPSGLTFAFLVVFMMAIMYNSVQVTADADADAEAEALANALAEAGILMYQGLGEKSDGLDQGQNGKVVAKK
What is the function of this protein?
Peptide with unknown function that does not resemble any other pilosulin-like peptide and appears to have a coiled coil structure.
What are the official names of this protein?
U-poneritoxin(01)-Om7a, U-PONTX(01)-Om7a, Pilosulin-like peptide 9, PLP9, Poneratoxin.
What is the protein family that this protein belongs to?
Belongs to the formicidae venom precursor-01 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL14_PSECP
Sequence: MIQQESRLKVADNTGAKEILTIRVLGGSGRRYAGIGDVIVATVKDAIPGGNVKKGDVVKAVIVRTKKERRRADGSYIKFDENAAVILKNDGDPRGTRIFGPVGRELRDKKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: Y1779_STRMU
Sequence: MNLRVKQKIPLKIKRMGINGEGIGFYKRTLVFVPGALKGEEIFCQITSVKHNFVQARLLTINKKSKFRVRPACPIYEECGGCQIMHLRYDKQLDFKKDLLKQALKKFKPQGYETYDIRATIGMEHPQHYRAKLQFQTRKFGGSVRAGLFKEQSHHLVDIKDCLIQDELTQKIVNRVCQLLDDYNIPVYDERRHFAGVRTIMVRKSQATNQVQLIFVTSKEVNLVGIIRDLTGYFPEIKTVAVNFNSSKSSAIYGQKTEILWGIDSISEEVLDYSFSLSPRAFYQLNPQQTQVLYHQALQALDVTAEDHLIDAYCGVGSIGLAFANKVKSVRGMDIIPEAITDAKRNAERMGYTNTYYEMGKAENVIPKWYKDGYQASALIVDPPRTGLDEKLLKTLLTYQPEKMVYVSCNVSTLARDLVQLVKVYEVNYIQSVDMFPHTARTEAVVKLVKRKQNSCSKK
What are the official names of this protein?
Uncharacterized RNA methyltransferase SMU_1779c.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: Y1049_NEIMA
Sequence: MFEQEDEWISKTQMKKQMNGLQDLGMELTKLSNDTLKKIGLDEDLYEAVVTYKKITSNGALKRQAQFIGRLMRDTDPAPIEAFLAKLRGDDAAHNAFLQRVEQARVRLLADDGALTQFMSDFPHADAGKLRTLIRNTKKEQEQNKPPKNFRALFQELKTVMESQGGTGEA
What are the official names of this protein?
UPF0307 protein NMA1049.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: RL22_TERTT
Sequence: MEVAAKLRGAGLSAQKARLVADQIRGKSVEEALDLLAFSTKKGAAVIKKVLESAIANAEHNEGADVDELKVSTIFVDEGLTMKRIRPRAKGRADRIFKRTCHITVKVADQ
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.