PharMolix/UniProtQA huggingface dataset:
Protein: QUEF_SINFN
Sequence: MPKTDVSGLSQLGTKVDLPQSPEEAVLERVPSGHEGTDFVVRFTAPEFTSLCPMTGQPDFAHIVIDYVPDGWLVESKSLKLFLHSFRNHGAFHEDCTVDIAKRLVSLLSPKWLRIGAYWYPRGGIPIDVFWQTGNPPEGVWLPDQGVPTYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_SHELP
Sequence: MSPQIDAVILAGGMARRMGGNDKGLVELNDQPMIKHAIDRIKPQVKQILINANRNQNRYAEFGYPVLSDEDSGYLGPLAGMITAMGQTQADYLLVVPCDCPLLPTDLVQRMLAAITAEDAEMAVASDGKREQPVVLLMKPALRGSMKAFLDAGERKIDFWYAKHHCVVCDFSDQPNAFVNVNTPEQKQQLSEAIAH
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NNRD_PONAB
Sequence: MALGPRYGAIRACGRVLERAFSLRKAHSIKDMENTLQLVRNIIPPLSSTKHKGQDGRIGVVGGCQEYTGAPYFAAISALKVGADLSHVFCASAAAPVIKAYSPELIVHPVLDSRSAVHEAEKWLPRLHALVVGPGLGRDDALLRNVQGILEASKARDIPVVIDADGLWLVAQQPALIQGYRKAVLTPNHMEFSRLYDAVLRGPMDSNDSHGSVLRLSQALGNVTVVQKGERDILSNGQQVLVCSQEGSSRRCGGQGDLLSGSLGVLVHWALLAGPEKTNGSSPLLVAAFGACSLTRQCNHQAFQKHGRSTTTSDMIAEVGAAFSKLFET
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ATP-dependent (S)-NAD(P)H-hydrate dehydratase, ATP-dependent NAD(P)HX dehydratase, Carbohydrate kinase domain-containing protein, NAD(P)HX dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL9_SYNC1
Sequence: MDIILMENVDGLGQIGDLVKVKPGYARNFLIPQKFAVEANTRNIKELEHQKRQLEHKAQKVLQASEVVKAQIEKVTCEFALRAGDDGKLFGSVTSMEIQAKLAESGVEVDRKKIQLDEPIKALGEYEVAVKLPAGILATVKVAVTALD
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: VN1R4_PONPY
Sequence: MASRYVAVGMMLSQTVVGVLGSFSLLLHYLSLHYIGCRLRSADLIVKHLIAASFLTLLCKGVPQTMAAFRVRYFLNAIGCKLVFYLHRVGRGVSTGTTCLLSVFQVITVSSRKSRWAKLKEKAPKHVGFSVLLCWILCMLVNIIFPIYVTGKRNHTNITVNKDLGDCCGRGNNKIAQTLRAMLLSFPDVLCLGFMLWASSSMVCILHRHKQRVQHIHRSNLSPRASPENRATQSILIPVSTFVSSYTLSCLLQVCMALLDNPNSLLVNTSALMSACFPTLSPFVLMSCDPSVYRLCFAWKR
What is the function of this protein?
Putative pheromone receptor.
What are the official names of this protein?
Vomeronasal type-1 receptor 4, V1r-like receptor 4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HGD_RHILW
Sequence: MDQTSIQASGGESATASTLKYMPGFGNDFETESLPGALPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPSVRHTRRFSNASYPLWKTAPCLDEHSLPLGQLRWDPIPAPEERLTFLEGVRTITTAGDAATQVGMSAHAYVFNQDMVDDYFFNADGELLIVPQLGALRVFTEMGIMDVEPLEICLIPRGMMFKILKTGEQAVWRGYICENYGAKFTLPDRGPIGANCLANPRDFKTPVAAFEDKETPCRVHVKWCGKFYVTEIGHSPLDVVAWHGNYAPFKYDLRTFSPVGAIRFDHPDPSIFSVLTAPTEDAGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIHGQYDAKEEGFVPGGMSLHNMMLPHGPDALAFEKAANAELKPVKLDHTMAFMFETRYPQQLTKYAAELETLQDDYLECWDGLERKFDGTPGIK
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: TSKA_XENLA
Sequence: MALSSWIFFLLVHGIVGGSRTCFPGCRCIVDNFGLFHSFSLTKVDCSRVGPHVVPVSIPLDTSYLDLSSNRLKRINESVLSGPGYTTLMNLNLSYNQIVKISYSTFSKLRYLESLDLSHNLLETLPDGSFLYSRLTELDLSSNKIQKVGVGAFTLKSQGRSMTINLANNEIHSIFRGAERPVPNIHSLMLYGNQLLSVPDLHGIPLRHLNLDRNPLSKIEKVSFLGLESLTHLSLSDLPNLREVSPYSFKSLTSLLELDLSNNPNLKSLSSDMFFGLKALQELNLAYSGVASLPKDIMLHLPSMKSITWGENIRCLKTVKESIFHAQKGRVRKEVLLCHDDNGAVPAQDIL
What is the function of this protein?
Contributes to various developmental events through its interactions with multiple signaling pathways (PubMed:15363410, PubMed:16319115, PubMed:17925852).  Dorsalizing factor which functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation (PubMed:15363410, PubMed:16319115, PubMed:17925852).  Promotes dll1-dependent activation of Notch signaling and is required for neural crest formation (PubMed:16319115).  Induces endoderm and dorsal mesoderm formation by enhancing nodal2/Xnr2 activity while inhibiting ventrolateral mesoderm formation through inhibition of fgf8 (PubMed:17925852).
What are the official names of this protein?
Tsukushi-A, Leucine-rich repeat-containing protein 54, X-TSK.
What are the subcellular locations of this protein?
Secreted.
Protein: SPSB3_MOUSE
Sequence: MARRTRSSRAWHFVLSAARRDTDARAVALAGSSNWGYDSDGQHSDSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDEDFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTSLQYLCCYRLRQLRPNSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCNHWKSPVPPPGTATPGAESLETRPCQRKRCRRS
What is the function of this protein?
May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
SPRY domain-containing SOCS box protein 3, SSB-3.
What is the protein family that this protein belongs to?
Belongs to the SPSB family.
Protein: IGO1_SCHPO
Sequence: MVRTRKWMLSTTIIAMSSSNSEQKVDVAKLSPEEQKLFRLYGRLPQRKDLLVQKLQQGRKYFDSGDYALNKAGKASDSGITCIGKEIPSPDTIPHRVVSAGSPNKEPSLHTKRPSESSPSGASSRRESVTRHDLESNEN
What is the function of this protein?
Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.
What are the official names of this protein?
mRNA stability protein mug134, Initiation of G zero protein 1.
What is the protein family that this protein belongs to?
Belongs to the endosulfine family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GUAA_RIPO1
Sequence: MTTQTPPITNPSEKLPTEPINKALNRQMLVILDFGSQYSELIARRIRETQVYSEVLSYRTTIEQIRQLNPRGIILSGGPNSVYDNRAPQCDPEIFHLGVPILGVCYGMQLMVQQLGGQVERAKRGEYGKASLFIDDPTDLLTNVEDGSTMWMSHGDSCTQLPEGFDILAHTENTSCAAIAHHQKKLFGVQFHPEVVHSVGGIALIRNFVYHICQCEPTWTTEAFVEESIREIRAKVGDKRVLLALSGGVDSSTLAFLLHRAIGDNLTCMFIDQGFMRKGEPERLVEIFDKQFHIPVEYVNARTRFLEQLAGVTDPETKRRLIGHEFIQVFEEESERLGPFDYLAQGTLYPDVIESADTNVDPQTGERVAVKIKSHHNVGGLPKNLRFKLVEPLRKLFKDEVRKLGRAIGLPEEIVRRHPFPGPGLAIRIIGEVTAERLNILRDADFIVRDEISKQGMYHDFWQAFAVLLPVRSVGVMGDRRTYAHPIVLRLITSEDGMTADWAKVPYDLLETISNRIVNEVKGVNRVVYDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ORF24_TTVV2
Sequence: MWTPPRNDQQYLNWQWYSSILSSHAAMCGCPDAVAHFNHLASVLRAPQNPPPPGPQRNLPLRRLPALPAAPEAPGDRAPWPMAGGAEGEDGGAGGDADHGGAAGGPEDADLLDAVAAAETRPQETQEGHRGVPLQPRRGAKRKLTFPPSQAPQTSPPVGRLAAGGKRVAKLRGRDADRLPAAQAAAAATANPGSQTQTPVQPSPKNPPKSRYQPYLVTKGGGSSILISNSTINMFGDPKPYNPSSNDWKEEYEACRIWDRPPRGNLRDPPFYPWAPKENQYRVNFKLGFQ
What are the official names of this protein?
ORF2/4 protein.
Protein: RL30B_SCHPO
Sequence: MSAAPTTAPVAAVSKKGKKSGDTINSKLALTMKSGKYVLGYKSTLKTLRSGKAKLILIAANAPPLRKSELEYYAMLSRCSVHHYSGNNIDLGTACGKLFRVGVLAVIDAGDSDILAA
What are the official names of this protein?
60S ribosomal protein L30-2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
Protein: PRP46_ASPFU
Sequence: MDVFPSTTPDEAVRKSAKRTAELFGSEYLLVTPSVADGSIGLSYRKKAEYSDVKELPPALAEKQAKAAAAGRAKRPKIQPQTKPQADGSGASMSLVKRAAGPAAGGVGGEGQPKSLIQRPSATRQQRPDWHPPWKLMRVISGHLGWVRSLAVEPNNEWFASGAGDRTIKIWNLATGALRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLALHPRLDLLVTGGRDGVARVWDMRTRSNIHVLSGHKGTVADLKCQEADPQIITGSLDATVRLWDLAAGKTMGVLTHHKKGVRNLAIHPREFTFASASTGSIKQWKCPEGDFMQNFEGHNAVINSLAVNEDNVLFSGGDNGSMCFWDWKTGYKFQSIDTMAQPGSLDAEAGIMSATFDRTGLRLITGEADKTIKVWKPDDEATPESHPVTWAPTLGRQRY
What is the function of this protein?
Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
What are the official names of this protein?
Pre-mRNA-splicing factor prp46, Pre-mRNA-processing protein 46.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PRL1/PRL2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KAD_BACSU
Sequence: MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETPLGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEEYGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQRADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase, Superoxide-inducible protein 16, SOI16.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNCB_SALTY
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADAIREQVDAMQHLRLLEDEFQWLSGLPFFKPDYLNWLREFRYNPAQVCVTNDNGKLNIRLTGPWREVIMWEVPLLAVISELVHHYRSPNAGVDQALDALESKLVDFTALTANLDMSRFHLMDFGTRRRFSREVQQAIVKRLQQESWFVGTSNYDLARRLALTPMGTQAHEWFQAHQQISPDLATSQRAALAAWLNEYPDQLGIALTDCITMDAFLRDFGIEFASRYQGLRHDSGDPVAWGEKAIAHYEKLGIDPLTKTLVFSDNLDLPKAVELYRHFASRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPQVRKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: LIPB_HAEIE
Sequence: MNNSLIVRQLGLQDYQEIWHKMQDFTDTRNAETQDEIWLVQHYPVFTQGQAGKPEHLLQRSEIPVVQSDRGGQITYHAPGQQVMYVLIDIKRHKNLNVRQLVTALEQTVVKTLAEYGIESYPKPDAPGVYVDGKKICSLGLRIRRGCSFHGLALNINMDLNPFHYINPCGYAGLEMCQLADFVNQDEADCDNVSAKLIKHFADLLGYNITTL
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_SUHVK
Sequence: MEESAGATSAQSAATSVSESPAEETILVCASEPVTVDGGRLLVCRSPGPEGFYKVPLGLKVALPTGYAMLVAQRGGGRTTNGIVDAGFRGEVQAIVAPGRPRAQFYCTPLRLAPGIATDVPFFEVFAPKRDEDAGYDIPCPRELVLPPGGAETVTLPVHRTDGRHWAYVFGRSSLNLRGIVVFPTPWESGPCRFRIQNRGAHPVTLESGQRVAQLVLTREPLGWITGRSPFPATPRAPMQHRPAWLFARDFVAPSSARGARGFGSTGL
What is the function of this protein?
Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: GLB1_MORMR
Sequence: MPIVDSGSVSPLSDAEKNKIRAAWDLVYKDYEKTGVDILVKFFTGTPAAQAFFPKFKGLTTADDLKQSSDVRWHAERIINAVNDAVKSMDDTEKMSMKLKELSIKHAQSFYVDRQYFKVLAGIIADTTAPGDAGFEKLMSMICILLSSAY
What are the official names of this protein?
Globin-1, Hemoglobin I.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RL7_MYCGE
Sequence: MGKLDKKQLIESLKEMTIVEIDEIIKAVEEAFGVTATPIVAAGAAGATQEAASEVSVKVTGYADNAKLAVLKLYREITGVGLMEAKTAVEKLPCVVKQDIKPEEAEELKKRFVEVGATVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: TUSD_SODGM
Sequence: MSLDYCLMVTGPAYGNQRASSALQFARALLECGHRLGTVFFYQDGVHNANRLSAPAGDEVDLVRAWHELAQQHQVALHVCAAAALRRGVTDALQASLLKRSGENLQPGFELSGLGSLVQAALGCDRFIQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_CLOD6
Sequence: MSEVRVRENETLDSALRRFKRQCAMSGIMSEVRKREHYDKPSVKRKKKAEAARRKNAKK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: IL1B_RAT
Sequence: MATVPELNCEIAAFDSEENDLFFEADRPQKIKDCFQALDLGCPDESIQLQISQQHLDKSFRKAVSLIVAVEKLWQLPMSCPWSFQDEDPSTFFSFIFEEEPVLCDSWDDDDLLVCDVPIRQLHCRLRDEQQKCLVLSDPCELKALHLNGQNISQQVVFSMSFVQGETSNDKIPVALGLKGLNLYLSCVMKDGTPTLQLESVDPKQYPKKKMEKRFVFNKIEVKTKVEFESAQFPNWYISTSQAEHRPVFLGNSNGRDIVDFTMEPVSS
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: Y10B_BPT4
Sequence: MEQYDLYENESFANQLREKALKSKQFKLECFIKDFSELANKAAEQGKTHFNYYCIARDKLITEEIGDWLRKEGFSFKVNSDQRDGDWLEITF
What are the official names of this protein?
Uncharacterized 11.0 kDa protein in Gp24-hoc intergenic region, ORF2.
Protein: FLOT1_HUMAN
Sequence: MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
What are the official names of this protein?
Flotillin-1.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family. Flotillin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endosome. Membrane, caveola; Peripheral membrane protein. Melanosome. Membrane raft. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity).
Protein: SHAN2_XENLA
Sequence: MVTPRLQTMAESSKFKKKVHFGETRSDRTKKLFRHYTVGSYDSFDASSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFNPTPAFPALQYLESVDEDGVAWQAGLRTGDFLTEVNNENVVKVGHRQVVNMIRHGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALSLRSKSMTSELEELAVDIASVRRRKDVQVSDVECLKRRIVIRVALNKSEESGPISKPLRPLDNTPVNSRVATVKQRPTSRCFPAASDTNSMYDRQGIAVIPPTTPGSHQGPFLGIPRGTMRRQKSIDSRIPLSGITEEERQFLAPPMLKFTRSLSMPDASEDIPPPPATLPPSPPPPSPSSFNSPKSPAPRGYGTIKPAFTQNSGTKSPSPAVRSDNVGTIARDKSMYFRHEANRFSLDSEELYNSNMSTQQNFINKRSKMPENPYSEVGRLGNKGVYVPAKPVRRKGMLVKQSNVEDSPEKTCSIPIPTIIIKEPSTSSSGKSSQGSSMETDLQISEQVGQLRPDESLNVSGPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDECVGPKPSPRLQHSKSIDDGMFCSEEKAKHFMAPSSLIINRGSSNAFTNNDSSHQGDVSNARMSKIKGPENNAAPAKSTNASGNYMHPVTGKLLDPNSPLALALAARDRALKEQNQPSPSPTDPEKADLNKPLFIDTKLRSGMETINANRPNMRGMLKRQETESKHEPDSSKEEKRQGEKKNMLINIMDTSQQKTAGLLMVHTVDTTKADNVLTESEEAEKDPPPENSNSPVSEPREELENSIPKASECGTPAAPHIKAIVSVCSVEEPVILPFRIPPPPFASVDVDEDFVFTEPLPPPLEFANSFDIPEDASQIPPASLADLLIQRKNRAFPPPSFNPNIASNSIESKRLAALSNCLPTSFMQHPESFDNVTDSGIEEVDSRSGSDHHLETTSTISTVSSISTLSSEGGENLDTCTVYADGQAFLVDKPPVPPKPKVKPIINKSNALYKDAVLEENLDNFAVPLPAPPPLPLSIQPSMTKAGQQRTSKLWGDNTEVKSLVMPSPKANVISELNSILQQMNREKATKTGEGLDSPTGMKTASLSTRGTDALSTVSGNRNAAVTFTIRPGANQPISLQNRTPEFDSRVTGMRRAPSPVVVSPAEIIRDIKPGPLSAPPASMSDVFILPSQPPSGDMFGMSMGRSRSPSPSILQQPISNKPFSAKPIHMWTKQDVAEWLESLHLGEHREMFMDNEIDGTHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR
What is the function of this protein?
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton.  May play a role in the structural and functional organization of the dendritic spine and synaptic junction (By similarity).
What are the official names of this protein?
SH3 and multiple ankyrin repeat domains protein 2, Shank2.
What is the protein family that this protein belongs to?
Belongs to the SHANK family.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Postsynaptic density. Note=Cytoplasm, postsynaptic density of neuronal cells.
Protein: CED9_CAEEL
Sequence: MTRCTADNSLTNPAYRRRTMATGEMKEFLGIKGTEPTDFGINSDAQDLPSPSRQASTRRMSIGESIDGKINDWEEPRLDIEGFVVDYFTHRIRQNGMEWFGAPGLPCGVQPEHEMMRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNAQTDQCPMSYGRLIGLISFGGFVAAKMMESVELQGQVRNLFVYTSLFIKTRIRNNWKEHNRSWDDFMTLGKQMKEDYERAEAEKVGRRKQNRRWSMIGAGVTAGAIGIVGVVVCGRMMFSLK
What is the function of this protein?
Plays a major role in programmed cell death (PCD, apoptosis) (PubMed:7907274, PubMed:10688797).  egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 (PubMed:9024666, PubMed:9027313, PubMed:9604928, PubMed:12894216, PubMed:15383288, PubMed:16208361).  During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway (PubMed:26074078).  Has been shown in one study to be dispensable in mitochondrial dynamics and morphology during early embryonic development (PubMed:19327994).  However, another study shows that a egl-1/ced-9 containing complex may promote drp-1-dependent mitochondrial fission (PubMed:21949250).
What are the official names of this protein?
Apoptosis regulator ced-9, Cell death protein 9.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Perikaryon. Synapse. Endomembrane system; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cytoplasm. Note=Intracellular membranes, mitochondrial, and perinuclear region (PubMed:9027313, PubMed:10688797). Localizes to synapses of DD motor neurons (PubMed:26074078). Synaptic localization is dependent on axonal mitochondria (PubMed:26074078).
Protein: HGFL_BOVIN
Sequence: MGWLPLLLLLIWFSGAPGQRSPLNDFQVLRGTELQHLLHSVGPGPWQEDVANAEECAGLCGPLLDCRAFHYNLSSHGCQLLPWTQHSPHTRLQRSGRCDLFQKKNYVRTCIVDNGVEYRGTVAITVGGLPCQRWSHRFPNDHKFTPTLRNGLEENFCRNPDRDPGGPWCYTTDPAVRFQSCGIKSCREATCLWCNGEDYRGSVDSTESGRECQRWDLQHPHPHPFEPGFWTKIWTTTIAGIRTARSGPGAIPPTRRWRESSATYPAAVQRSEAQPSQEATTLNCFRGKGEGYRGTVNTTAAGVPCQRWDAQLPHQHRFAPEKYACKDLRENFCRNPDGSEAPWCFTSRPGMRMAFCYQIRRCTDDVRPEDCYHGAGELYRGSVSKTRKGIRCQNWSAETPHKPQFKHTSAPHTPLEENFCRNPDGDSHGPWCYTTDPGTPFDYCALRRCDDDQQPSILETAHQVLFDKCGKRVTRVDPLHSKLRVVGGQPGNSPWTVSLRNRQGQHFCGGSLVKEQWVLTARQCFSSCHMSLVGYEVWLGTLFQDPQPGEPDLQHIPMAKMVCGPSGSQLVLLKLERPVILNQRVALICLPPERYVVPPGTRCEIAGWGETKGTGDDTVLNIALLSVISNQECNVKHRGRVRESEMCTAGLLAPVGACEGDYGGPLACFTHDCWVLQGIIIPNRVCARPRWPAVFMRVSVFVDWIHKVMRLG
What are the official names of this protein?
Hepatocyte growth factor-like protein, Macrophage stimulatory protein, Macrophage-stimulating protein, MSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Plasminogen subfamily.
What are the subcellular locations of this protein?
Secreted.