PharMolix/UniProtQA huggingface dataset:
Protein: ENV_HV1BR
Sequence: MRVKEKYQHLWRWGWKWGTMLLGILMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLGNATNTNSSNTNSSSGEMMMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYTLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSANFTDNAKTIIVQLNQSVEINCTRPNNNTRKSIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNATLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQFINMWQEVGKAMYAPPISGQIRCSSNITGLLLTRDGGNNNNGSEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKIFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAIRHIPRRIRQGLERILL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: PUR7_RICB8
Sequence: MKKKLYEGSSKTLYSSEEEFLLVMAFSDKATLENGEIIDVSGKGVLNNNISSFVMNKLEMIGIENHFIEKLNMREQLIQYVEMFPLQVVVSSVACGRFVKEFGMDEGFVFDKPIIDFKVKSREFKYPIVNEHQILNFGWLTKDEINTVKKQALRIYDFLSGLFIGIGIRLVECNLEFGRVFTGEESLVMLTDEISPDTCKLWHINSNERLGFELLEKDPAKAYESYKLIADRLKEK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RL9_SHEWM
Sequence: MNVILLDKIANLGNLGDQVAVKAGYARNFLLPQGKAVVANAANTEVFEARRAELEAKLAADLAVATERADKINALESVVIASKAGDEGKLFGSIGNRDIADAVTAAGVELAKSEVRLPLGALRTTGEFEVEVQVHTEVKAIVKLSVVAED
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: HEM1_STAES
Sequence: MHFVAISINHRTADVTLREQVAFRDDALRLAHEDLYETKAILENVILSTCNRTEVYAIVDQVHTGRYYIQRFLARSFGFEVDDIKDMSQVKVGDDAVEHLLRVTSGLDSIVLGETQILGQMRDAFFLAQNTGTTGTIFNHLFKQAITFAKKAHSETDIADNAVSVSYAAVELAKKVFGKLKSKHAVVIGAGEMGELSLLNLLGSGISNVTIVNRTLSKAKILAEKHNVSYDSLSALPSLLETTDIVISSTSAEDYIITNSMVKTISETRKLDSLVLIDIAVPRDIEPGIDAITNIFNYDVDDLKDLVDANLRERQLAAETIAGQIPEEIDSHNEWVNMLGVVPVIRALREKAMNIQAETMESIDRKLPDLSERERKVISKHTKSIINQMLKDPIKQAKELSTDKKSNEKLELFQNIFDIEAEDPREKAKLEKESRAKEILAHRIFSFE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: AZOR1_PSEPF
Sequence: MSKILAIHASPRGERSHSRRLAETFLSAWQVRHPQAQVTRREVGRALIPAVNEAFVAAAFYPEPEARPLTMQADLALSDQLVGELFDHDLLLISTPMYNFNVPSGLKAWVDQIVRLGLTFDHTLDNGIAQYTPLLHGKKALIVTSRGGFGFGPGGELEALNHADPWLRTALGFIGINDVTVVAAEGEESAERTFAVSVAEAEQRLLDLARAF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 1, Azo-dye reductase 1, FMN-dependent NADH-azo compound oxidoreductase 1, FMN-dependent NADH-azoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: NARJ_ECO57
Sequence: MIELVIVSRLLEYPDAALWQHQQEMFEAIAASKNLPKEDAHALGIFLRDLTTMDPLDAQAQYSELFDRGRATSLLLFEHVHGESRDRGQAMVDLLAQYEQHGLQLNSRELPDHLPLYLEYLAQLPQSEAVEGLKDIAPILALLSARLQQRESRYAVLFDLLLKLANTAIDSDKVAEKIADEARDDTPQALDAVWEEEQVKFFADKGCGDSAITAHQRRFAGAVAPQYLNITTGGQH
What is the function of this protein?
Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 1.
What are the official names of this protein?
Nitrate reductase molybdenum cofactor assembly chaperone NarJ, Redox enzyme maturation protein NarJ.
What is the protein family that this protein belongs to?
Belongs to the NarJ/NarW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB7_BOVIN
Sequence: MAAVSVYERPVGGFSFDNCRRNAVLEADFAKKGYKLPTARKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPYSVPNKKGTRFGRYRCEKGTNAVLTEKVTTLEIEVLEETVQTMDTS
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).  Within the 20S core complex, PSMB7 displays a trypsin-like activity.
What are the official names of this protein?
Proteasome subunit beta type-7.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: WIPI4_HUMAN
Sequence: MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF
What is the function of this protein?
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066).  Binds phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:28561066).  Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066).  Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352).  Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066).
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat-containing protein 45.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure. Cytoplasm. Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy.
Protein: Y288_THEMA
Sequence: MPEIRRRPHGPILEKPALKNPTATLRRLLGYLRPHTFTLIMVFVFVTVSSILGVLSPYLIGKTIDVVFVPRRFDLLPRYMLILGTIYALTSLLFWLQGKIMLTLSQDVVFRLRKELFEKLQRVPVGFFDRTPHGDIISRVINDVDNINNVLGNSIIQFFSGIVTLAGAVIMMFRVNVILSLVTLSIVPLTVLITQIVSSQTRKYFYENQRVLGQLNGIIEEDISGLTVIKLFTREEKEMEKFDRVNESLRKVGTKAQIFSGVLPPLMNMVNNLGFALISGFGGWLALKDIITVGTIATFIGYSRQFTRPLNELSNQFNMIQMALASAERIFEILDLEEEKDDPDAVELREVRGEIEFKNVWFSYDKKKPVLKDITFHIKPGQKVALVGPTGSGKTTIVNLLMRFYDVDRGQILVDGIDIRKIKRSSLRSSIGIVLQDTILFSTTVKENLKYGNPGATDEEIKEAAKLTHSDHFIKHLPEGYETVLTDNGEDLSQGQRQLLAITRAFLANPKILILDEATSNVDTKTEKSIQAAMWKLMEGKTSIIIAHRLNTIKNADLIIVLRDGEIVEMGKHDELIQKRGFYYELFTSQYGLVVEKE
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein TM_0288.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CH60_BRUSU
Sequence: MAAKDVKFGRTAREKMLRGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEVELEDKFENMGAQMLREVASKTNDTAGDGTTTATVLGQAIVQEGAKAVAAGMNPMDLKRGIDLAVNEVVAELLKKAKKINTSEEVAQVGTISANGEAEIGKMIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMVADLEDAYILLHEKKLSNLQALLPVLEAVVQTSKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLESVTLDMLGRAKKVSISKENTTIVDGAGQKAEIDARVGQIKQQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVAGGGTALLRASTKITAKGVNADQEAGINIVRRAIQAPARQITTNAGEEASVIVGKILENTSETFGYNTANGEYGDLISLGIVDPVKVVRTALQNAASVAGLLITTEAMIAELPKKDAAPAGMPGGMGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_BLOFL
Sequence: MYKKKIKKNTITHFGFQNVPTFIKSYLVSNVFHKVATKYDLMNDLMSFGIHRIWKQFLIQQSEVHNGYKVLDLAGGTGDLSIKFSKLVGKKGIVILLDNNDTMLRLGQKKLRNLGILNNVHYIQANAEFLPFSENTFNCVAISFGLRNFTYKQKSLYEIYRVLRPGGKLLILDFSIPTSKLLTILYDLYSFHIIPKIGKIIAQDSKSYQYLVESIRMHPDQETLKNMILSIGFNDVQYFNMTGGIAALHCAYKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: METK_STAAR
Sequence: MLNNKRLFTSESVTEGHPDKIADQVSDAILDAILKDDPNARVACETTVTTGMALIAGEISTTTYVDIPKVVRETIKEIGYTRAKYGYDYETMAILTAIDEQSPDIAQGVDKALEYRDKDSEEEIEATGAGDQGLMFGYATNETETYMPLAIYLSHQLAKRLSDVRKDGTLNYLRPDGKVQVTVEYDENDNPVRIDTIVVSTQHADDVTLEQIQEDIKAHVIYPTVPENLINEQTKFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGCFSGKDPTKVDRSAAYAARYVAKNIVAAGLADQCEVQLAYAIGVAEPVSIAIDTFGTGKVSEGQLVEAVRKHFDLRPAGIIKMLDLKQPIYKQTAAYGHFGRTDVLFPWEKLDKVEELKDAVK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DJ1A_DROME
Sequence: MLSVLRKSFPNGVTHAHRVIRCKSNQDKCAKNALIILAPGAEEMEFTISADVLRRGKILVTVAGLHDCEPVKCSRSVVIVPDTSLEEAVTRGDYDVVVLPGGLAGNKALMNSSAVGDVLRCQESKGGLIAAICAAPTALAKHGIGKGKSITSHPDMKPQLKELYCYIDDKTVVQDGNIITSRGPGTTFDFALKITEQLVGAEVAKEVAKAMLWTYKP
What is the function of this protein?
Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor (PubMed:16139213, PubMed:16139214, PubMed:20457924).  Does not play a role in methylglyoxal detoxification (By similarity).
What are the official names of this protein?
Protein DJ-1alpha.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion.
Protein: GLGB_MYXXD
Sequence: MRKPADKAQVDAELQRVVELRHPEPHAVLGIHPDGDGVVIRAFRPDAVAIHVLPESGGRVAMTHRPGGVYEARINGKDQTFNYLLEVEYPGKRVFTLRDPYSFLPTLGEMDLYYAGEGRHERLWERMGAHLLHHHGVRGTSFAVWAPTAAGVSVVGDFNGWDGRLHSMRRMGSSGIWELFVPEVGEGTRYKFEIRPGQGGPNVLKADPFAFRTEVPPATASVVHDLARYTWGDAAWLEQRAQRRDVHHQPWSVYEVHLGSWRRVVEDGDRPMTYRELAPALAEYIKFTGFTHIELLPVAEHPYGGSWGYQVGGYYAPTARFGHPDDLRFFIDHMHQEGIGVLVDWVPGHFPRDLHALGQFDGTALYEHADPRKGAQPDWGTLVFNFGRNEVRNFLIANALFWIEEYHIDGLRVDAVASMLYLDYSRKQGEWIPNRWGGRENEEAIHFLRELNETVHRKHPGVVVIAEESTAWPKVSAPVSEGGLGFDYKWNMGWMHDTLSYFSKDPIYRQYHHNQLTFGLLYAFSEQFMLPLSHDEVVHGKGSLYGRMPGDPWQKRANLRALFAWMWAHPGKKLVFMGGEFGQPAEWNHDKSLDWHLTHDPGHHGILQLVSDLNRIYRDMPALHDADGEPMGFQWLQPDSAAYNVFAFVRRARQPGRHVVCIANLSPTVRENYRVGFPFQGRYVELLNTDAEQYGGSNLGNMGQIHTEPTGWDGQPASATLTLPPLSVLWFTPG
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: DDLB_CLOPE
Sequence: MKVGIIMGGISSEREVSLASGESIFNHIDKEKYEVSKIIINNKIDILEKVKGLDFALLALHGKFGEDGTVQAFLDIMDIPYSGCGALSSSLCMDKNLSKKVLKAENIRTAKWITVKSIEEIDYEKIEEIGYPVFVKPNNGGSSVATFKVYKKEDIKNSVMEGLKYDEEVIIESFIKGREITCPIFNGELFPILEIKSKADFYDYKQKYAANGAEHLPVQLEKSLYDEVKEMALKTFEVLKCEVYARVDMIISEEGVPYILEVNTLPGMTATSLFPQSAESRGISYSKFIDLIIETSLNKKIK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase B, D-Ala-D-Ala ligase B, D-alanylalanine synthetaseB.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_LEUCK
Sequence: MPVIESAIQRVRLTKKQHDRNEPQASAYRTAVKRFEKAAAAGEDNLAELYKIASSAIDRAHSKGLIKKNKASREKSRLAKYVK
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ERG24_DICDI
Sequence: MSAVRNRNNVEKQSNNGAQLTEVQKKELADLQKVHPANEFGGIIGTFLLTFILPVVVYWIWASIEFNNGYLLRPETLSVEGVKAFLAQLYHYVITYAYPTKEAAIIYFSWFGFQAFLQHVVPGRKVLGSPLPGGARLEYTLNGWASWWITLIVIPIAIYFGLFKATILIDNYAPMMTVVNIWSFVFTFLLKIHAKLKGEEERMSGHFFYDFWMGFARNPRIGSFDLKLFCEARPGLILWVLMNFSIAAKQLEVYGEISLSVILVCCFHFWYIADYYYHEEAILTTMDIITEKFGYMLVYGDLSWVPFTYCFQCYYLYKHLVNGAPLHISIGYAIFVVSLKCFGFYLFRWVNSQKHDFRRNPEAPVWGKPAEFILTKRGTKLLCSGFWGICRHLNYTGDIILSWAWCLPCQFDSLAPYFYGIYFTSLDLHRCWRDHNACLVKYGDDWRAYCKRVPYNFIPGLI
What is the function of this protein?
Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.
What are the official names of this protein?
Delta(14)-sterol reductase, C-14 sterol reductase, Sterol C14-reductase.
What is the protein family that this protein belongs to?
Belongs to the ERG4/ERG24 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MRAZ_SALCH
Sequence: MFRGATLVNLDSKGRLTVPTRYREQLIESATGQMVCTIDIHHPCLLLYPLPEWEIIEQKLSRLSSMNPVERRVQRLLLGHASECQMDGAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSATETLSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SYA_GEOUR
Sequence: MTGKEIRAQFFKFFEERGHTVVESSNLIPRNDPTLLFTNAGMNQFKDVFLGLEKRDYVRACSSQKCVRAGGKHNDLENVGRTARHHTFFEMLGNFSFGDYFKKEAIAFAWEFLTKELKLDKDRLYVTVYTDDDEAADIWNRQEGVPLERIYRFGEKDNFWSMGDTGPCGPCTEIFWDNGPGTGCGSPTCEVGCDCDRYMEIWNNVFMQFNRDAQGNLTPLPKPSVDTGMGLERISTVMQGVTSNYDTDLLQGIIKHVEKLSGKRYRQDERDDVSMRVIADHSRAITFLICDGILPSNEGRGYVLRRIMRRAARHAKMLGFAEPALYRIVDAVNTMMGDAYPELLEREEYIKKVIHAEEERFIETLDRGLAILNEEVAALKKEGKSVVPGEVIFKLYDTYGFPVDLTADIVENEGFTIDEDGFALCMERQRLQARENWKGSGEEGLAEIYKTLHGRGIRSAFVGYSEQTAYSAITAILREGAEVAEAVAGEMVEVVVDTTPFYGASGGQAGDTGVISTGSAHLRVVATSKPFPDLTVHRALVTEGTVKAGDAADLRVATEVRGATARNHTATHLLQSALRQVLGEHVKQAGSLVTAERLRFDFTHFSAMTVEELRRVENIVNTYVMDNADVKSLEMAATEAMQSGATALFGEKYGDRVRVVKVGEVSSELCGGTHVRAAGDIGFFKIVGEAGIAAGVRRIEALTGSGALEYVQQLEDEQRSIAVLVKAEGGTALDKVDRLLARQKELQREVEALQARLNASRSADLLAGARETNGIKVLAAKVEMDDPKGLRELADSLKDRLQSGVIVIGCVSAGKANLLVAVTKDLSDRLRAGDIIKSLAPIIGGSGGGKPELAQAGGTKPENLDEALEAAYKIIG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHKC_DICDI
Sequence: MDSGLGSSYPEERSGPPEIRPEEINFEELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSAFRKEVHLMSKIYHPNICLFMGACTIPGRCVIVTELVPKGNLETLLHDQKIQLPLYLRMRMARDAALGINWLHESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKDQSSAKGTPLYMAPEVMMFKEFNESSDVYSFGIVLWEILTRKEPFSHHRELEKFREAVCVKHERPPIPNDCLDSLRRLIEKCWDKEPISRPSFKEIISALDHVIIDAAISDLNGRDFWKKSFLTEQEVPWEAFIDALCNWSKAPARNQCDKTSIDYLNIKCLKAVLAESPKSEGTGVETVVNIEKFGKILEFFGPVPEPAPGHSIMDTVREILSQKWFHGDLDTTEAASRLNGQPIGSFLIRFSSTNAGCFTISQVVDGGSIKHQRVSRQGVKFNYQNVIYNSLIEIVSKNGGGANGDVKLDSQLGVPNYKFMSLFCVLNKESEVYQ
What is the function of this protein?
Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells.  Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway.  Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity).
What are the official names of this protein?
Dual specificity protein kinase shkC, SH2 domain-containing protein 3, SH2 domain-containing protein C.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily.
What are the subcellular locations of this protein?
Membrane.
Protein: RK23_GOSBA
Sequence: MDGIKYVVVTDKSIRLLVKNQYTSNVESGSTRTEIKHWVELFFGVKVIAMNSHRLPGKGRRMGPIMGHTMHYRRMIITLQPGYSIPPLRTKRT
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MTNN_LYSSC
Sequence: MKIAVIGAMEEEVELLRASLNNAQRTTIAGSEYTTGTYEGKEVVLLKSGIGKVNAAMSTTILLHEFKPDVVINTGSAGGYDEALEVGAVVISDEVRHHDVDVTIFGYEIGQMAGMPAAYKSDERLMKVAEEAVKAVGEHQYGIGLICSGDAFMNDPERVEAVRHHFPQMKAVEMEAAAVAQVCYQFATPFVVIRALSDIAGKESNISFDEFLPVAAKHSTQVVLKAIASL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.