PharMolix/UniProtQA huggingface dataset:
Protein: LOLD_SALRD
Sequence: MHRGAATQGLVFTTPLSPFILPFAVDTPLLQVDALLKQYDTGGDEPLTVLRDLDLAVQEGEILAIVGESGTGKSTLLHLLGALDRPTDGTVRFAGTDLFAKSDEELAAFRNRSIGFVFQFHHLLPEFTALENVAMPALIQHRSLADVTPRAHELLALLGLDDRADHRPRTLSGGEKQRVAIARALMNEPALVLMDEPTGNLDARTAEPLHREIERLSREMDHTFVLASHDPSLAEVAGRVLRLEHGTLHPLAAADEMAPEAGPSDDGHAGG
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ESR1_RAT
Sequence: MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPAVFNYPEGAAYEFNAAAAAAAAGASAPVYGQSSITYGPGSEAAAFGANSLGAFPQLNSVSPSPLMLLHPPPHVSPFLHPHGHQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSSEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGTSGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPLIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKINDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQSQLTTTSSTSAHSLQTYYIPPEAEGFPNTI
What is the function of this protein?
Nuclear hormone receptor.  The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.  Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling.  Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components.  Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.  Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter.  Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP.  Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences.  Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP.  Can activate the transcriptional activity of TFF1.  Also mediates membrane-initiated estrogen signaling involving various kinase cascades.  Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
What are the official names of this protein?
Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Protein: MNMA_PROMA
Sequence: MTITPKNKRTSSIPKSQTATIGGEEVLKKLKGVEGDHSIAVGLSGGVDSSLTAALLVEAGWNVEGITLWLMSGKGSCCTDGLVDAAGICEQLGIPHHVIDARETFQREIIESLVKGYQEGMTPSPCSKCNRFVKFSPILEWAEQNLGLKRIATGHYARIKHLQEPIKISSAKENQIRRHQLLRGLDQNKDQSYFLYDLSQEILEKVIFPLGELKKADTRKEASRIELRTAEKPESQDLCLAEHHGSMKAFLDEYISPRNGEILLSNGQLLGQHDGIEHFTIGQRKGLGIAWKEPLHVIEIQSSTNRVIVAPRSEASRDNCTVGSINWVSIEPPSKKTIVEVQLRYRSKPVLATLTPIKPLKKDIENDRPYRCNLQFQSEQFSITPGQAAVFYEGEILLGGGIIEGN
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRP54_PYRAE
Sequence: MKALTEIFGKLLEKIRGVDYIDEATLQELSREIQRTLLKADVPLDLVKSFTENAVKRIKEEKPPAGIPPREYLIYVLYEELVKLLGGEQPAEFKPTKKPYIVLLLGVEGSGKTTTAAKLAKYLAKRGYKVGLVETDTIRPAAFDQLRQLAEKIGVPFYGERDGKDAVEIAKRGVQNFKNMDVIIVDTAGRHRNEEALLKEVRAIYDAVSPDEVVLVIDATVGKMAAAQAEAFMKYLPIHSVIITKMDSTARGGGALAAVAKTGAKVKFIGVGEDVDEFEQFSPRKFVARVLGMGDLDTLLEKIKAVFEEEEVLEEIESGRLDLLTFKKQIDSLLKLGPLSKVFQLLPGNLAAKISEEQIELSQRNLKKWRAILSSMTLEELKNPEILNASRIRRIALGAGVAPKDVKEMLTVYENLRKMSKTLRRQLRLRMAK
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle 54 kDa protein, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: RPOB_LISMO
Sequence: MSGHSGHDVKYGRHRTRRSFARISEVLELPNLIEIQTASYQWFLDEGLREMFRDISPIEDFAGNLSLEFIDYDLGEPKYSVEESKNRDANYAAPLRVKLRLINKETGEVKDQEVFMGDFPLMTEMGTFIINGAERVIVSQLVRSPGVYFNGKLDKNGKKGFGSTVIPNRGAWLEYETDAKDVVHVRIDRTRKLPVTVLLRALGFGSDQEIIDLIGDNDYLRNTLEKDNTDNAEKALLEIYERLRPGEPPTVDNARSLLVSRFFDPKRYDLASVGRYKINKKLHLKNRLFNQTLAETLVDPETGEIIASKGDILDRRNLDQIIPNLENGVGFRTLRPTDGVMEDSVLVQSIKIYAPNDEEKEINIIGNAYIEENVKHITPSDIISSISYFFNLLHGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDMTTITPQQLINIRPVVASIKEFFGSSQLSQFMDQTNPLGELTHKRRLSALGPGGLTRERAGYEVRDVHYSHYGRMCPIETPEGPNIGLINSLSSFAKVNKFGFIETPYRRVDPETNRVTDKIDYLTADEEDNYVVAQANSKLDEQGTFTEEEVMARFRSENLAVEKERIDYMDVSPKQVVSVATACIPFLENDDSNRALMGANMQRQAVPLMHPEAPFVGTGMEHVSAKDSGAAVTAKHDGIVEHVEAREIWVRRVSLVDGKEVTGGIDKYTLRKFVRSNQGTCYNQRPNVAEGDRVVKGEILGNGPSMDSGELALGRNVLVAFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEFESEARDTKLGPEEMTRDIPNVGEDALRDLDERGIIRVGAEVKDNDLLVGKVTPKGVTELTAEERLLHAIFGEKAREVRDTSLRVPHGGGGIVLDVKIFTREAGDELPPGVNQLVRVYIVQKRKIHEGDKMAGRHGNKGVISRILPEEDMPFMPDGTPVDIMLNPLGVPSRMNIGQVLELHLGMAARALGIHVATPVFDGANEEDVWSTVEEAGMARDAKTILYDGRSGEAFDNRISVGVMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEILTIKSDDVVGRVKTYEAIVKGESVPEPGVPESFKVLIKELQSLGMDVKMLSADEEEIEMRDMDDDDFTNQNDAFNIVQPENAAAEKTE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PIMT_ANAD2
Sequence: MSTELAAWLGHMGIRDRRVLDAIAALDRARFVSRDLSAEAYADRPLPIGFGQTISQPYVVAFMTEALELEGGERVLEVGTGSGYQTALLARLAGEVWSVEIVPGLAARARALLLEELGLANVHLREGDGALGWPEAAPFERILVTAAAPRVPPALRAQLAPGGRMVLPVGEAESEQVLRVVERGADGIEESEDVLPVRFVPLTHLPPAV
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXC6_NOTVI
Sequence: MNSYFTNPSLSCHLASGQEVLPNVALNSSAYDPVRHFSTYGEAVAQNRIYSSPFYSPQDNVVFSSGRGPYEYGSNAFYQDKDMLSSCRQNAMGHNTQTSIAQDFSSDQSRASVQEQKTSIQIYPWMQRMNSHSGVGYGTDRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANASCLTERQIKIWFQNRRMKWKKESNLTSTLSGGTGAASDSLAEGKEKEEETEEEQQKE
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-C6, FH-2, NvHox-1.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KCNC3_RAT
Sequence: MLSSVCVWSFSGRQGTRKQHSQPAPTPQPPESSPPPLLPPPQQQCAQPGTAASPAGAPLSCGPGGRRAEPCSGLPAVAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSGNANANAGGAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGPGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPPGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIETNRAGNDLGVLEEGDPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLVTDYAPSPDGSIRKATGAPPLPPHAGVSQAPPASCPTSTPTQQPGYPPSGRAPSPPQATPEAPAIFDVWLPPFHRSHQPPGKHQRGGRHPGVSPSPQQRACVGEPPSASHPQSLTLCISVPSSCHRLRPRETLGFPLSLPPRLATGNGGRECPRDPGLPFPSRHSSPAV
What is the function of this protein?
Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons.  The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient.  The channel displays rapid activation and inactivation kinetics (PubMed:1381835).  It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells.  Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis.  Required for normal motor function (By similarity).  Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (By similarity).
What are the official names of this protein?
Potassium voltage-gated channel subfamily C member 3, KSHIIID, Voltage-gated potassium channel subunit Kv3.3.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (PubMed:20857303). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (By similarity).
Protein: RS11_THET8
Sequence: MAKKPSKKKVKRQVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQLAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDTPVPHNGCRPKKKFRKAS
What is the function of this protein?
Located on the upper part of the platform of the 30S subunit, where it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome, where it interacts both with the Shine-Dalgarno helix and mRNA.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: MUKF_HAEDU
Sequence: MQNELAQTIPELISWTKEREFSLSLPSDRLAFLLVISIYNNEQTDGELLESDLIDLFRYVSNVFEQSEASLLQRANNAINDLVKQRFLNRFSSEFTEGLAIYRVTPLGVGVSDYYVRQREFSSLRLSIQLSIVADEIQRASVAAEQGGDERYWRNNVFAPLKFSVAEIFDSIDLSQRMMDENQHQIREQIAGLLSQNWHEAIINCQQLLDETSINLRELQDTLNAAGDKLQSQLLRIQSCLISRDDLAFVDQLIVNLQNKLDRIMSWGQQAIDLWIGYDKHVHKFIRTAIDMDKNRVFGQRLRQSIQNYFSSPWLLYTAKAEALLDLRDDEAMLNEMEAVGELPMALEYESLTDVQTQIVTAIQAELAHFRDTAQPINLGAVLREQLARYPQSRHFDVARIIVDQAVKLGMASQDHQAVYPVWQPIDDFSAAVQAHLIDQYDK
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: ENLYS_BPAPS
Sequence: MHISEKGLVLIKRYEGLRLKAYQCRAGRWTLGYGHTHNLNIGDVITQEQAEAFLREDIAQVTALLNTQIKVPLTQNQYDAICSLVFNIGMTAFTTSTLLKKLNVGDYSGASAEFMKWSKAKVNGKRTPLPGLIKRRQAEKALFESA
What is the function of this protein?
Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles.  Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.
What are the official names of this protein?
Endolysin, Lysis protein, Lysozyme, Muramidase, P13.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 24 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.
Protein: OR2F2_HUMAN
Sequence: MEIDNQTWVREFILLGLSSDWCTQISLFSLFLVTYLMTVLGNCLIVLLIRLDSRLHTPMYFFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLFFSLALGGIEFVLLAVMAYDRHVAVSDRLRYSAIMHGGLCARLAITSWVSGSINSLVQTAITFQLPMCTNKFIDHISCELLAVVRLACVDTSSNEAAIMVSSIVLLMTPFCLVLLSYIRIISTILKIQSREGRKKAFHTCASHLTVVALCYGTTIFTYIQPHSGPSVLQEKLISVFYAIVMPLLNPVIYSLRNKEVKGAWHKLLEKFSGLTSKLGT
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2F2, Olfactory receptor 7-1, OR7-1, Olfactory receptor OR7-6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURG_YERP3
Sequence: MSGKTKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEASLVPQHGIEIDFIKISGLRGKGLMAQLTAPIRIYRAVRQAQKIMRDYQPDVVLGMGGYVSGPGGLAAWLCGVPVVLHEQNGIAGLTNRWLARIAKKVLQAFPGAFPNADVVGNPVRTDVLALPLPAVRLSGREGPIRVLVIGGSQGARILNQTLPLVAASLGEQITLWHQVGKGALPEVSQAYQQAGQAGHQVVEFIDDMAAAYAWADVVVCRSGALTVSEVAAAGLPAIFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQFTATSVSSLLAGWDRATLLSMAERARSVAIPDATERVAAEVVAASKSA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GRB10_MOUSE
Sequence: MNNDINSSVESLNSACNMQSDTDTAPLLEDGQHASNQGAASSSRGQPQASPRQKMQRSQPVHILRRLQEEDQQLRTASLPAIPNPFPELTGAAPGSPPSVAPSSLPPPPSQPPAKHCGRCEKWIPGENTRGNGKRKIWRWQFPPGFQLSKLTRPGLWTKTTARFSKKQPKNQCPTDTVNPVARMPTSQMEKLRLRKDVKVFSEDGTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVESTMPSESKFLFRKNYAKYEFFKNPVNFFPDQMVNWCQQSNGGQAQLLQNFLNTSSCPEIQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPRHLQLLADLEESSIFYLIAGKKQYNAPNEHGMCIKPNKAKTEMKELRLLCAEDEQIRTCWMTAFRLLKYGMLLYQNYRIPQRKGLPPPFNAPMRSVSENSLVAMDFSGQIGRVIDNPAEAQSAALEEGHAWRKRSTRMNILSSQSPLHPSTLNAVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
What is the function of this protein?
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways.  Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors.  The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation.  Delays and reduces AKT1 phosphorylation in response to insulin stimulation.  Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation.  Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways.  A similar role in the mediation of ubiquitination has also been suggested with INSR.  Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6.  Positive regulator of the KDR/VEGFR-2 signaling pathway.  May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
What are the official names of this protein?
Growth factor receptor-bound protein 10, GRB10 adapter protein, Maternally expressed gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the GRB7/10/14 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R before the sorting of the receptor to the lysosomal compartment.
Protein: ARGL1_MOUSE
Sequence: MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNAAASRRERERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD
What are the official names of this protein?
Arginine and glutamate-rich protein 1.
What is the protein family that this protein belongs to?
Belongs to the UPF0430 family.
Protein: STF1_HUMAN
Sequence: MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
What is the function of this protein?
Transcriptional activator.  Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692).  Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B.  Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes.  5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692).  The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity.  Binds phosphatidylcholine (By similarity).  Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3.  Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
What are the official names of this protein?
Steroidogenic factor 1, SF-1, STF-1, hSF-1, Adrenal 4-binding protein, Fushi tarazu factor homolog 1, Nuclear receptor subfamily 5 group A member 1, Steroid hormone receptor Ad4BP.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DER_PSYWF
Sequence: MSMKPVVALIGRPNVGKSTIFNQMTKTRQALVADLSGLTRDRQYGDATYNNKSFVVIDTGGIGEADDGRGSIDDYMSAQSHTAIHEADILVFVVDARAGMIGADAEIGKMLHTLGKPVYLVANKIDGVHDAAPAEFYALGLGEPYPMTASHGRGIANLLDDLTADMPEDVEEEDQGGLKLAIIGRPNVGKSTLVNRMLGEERVVVYDMPGTTRDSIYIPFERNGKNYVLIDTAGVRRRGRIDEKVEKFSVIKALQAIKDANVVVAVIDAQEGIVDQDLHMLGYALDAGRAMVVAINKWDGLSEDKKEMIRIELDRRFNFIPYVKVHFISALHGTNVGNLYPSIHKAYASSMFKVSTNRLTQILEDAVAANPPPMSGGRRIKLRYAHLGGHNPPIIVIHGNQTGSLPKSYQRYLENEFRKVFNLEGTPLKVEFKLNTNPYAGKKTTSSKKLRPGVSEARQKRRNMKYKKGSHKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PDXH_YERPS
Sequence: MTENNEFDVADLRREYIRGGLRRSDLTENPLELFERWLKQACEARLPDPTAMCVATVDTNGQPYQRIVLLKHYDDQGLVFYTNLGSRKAQQLAENPHISLLFPWHMLDRQVIFLGKAERLSTLEVLKYFHSRPKDSQIGAWVSQQSSRISARGVLESKFLELKQKFQQGDVPLPSFWGGFRVKFDSVEFWQGGEHRLHDRFIYQREADAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: SLYX_ECO5E
Sequence: MQDLSLEARLAELESRLAFQEITIEELNVTVTAHEMEMAKLRDHLRLLTEKLKASQPSNIASQAEETPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.