PharMolix/UniProtQA huggingface dataset:
Protein: SECA_PSE14
Sequence: MFAPLLKKLFGSKNEREVKRMLKTVQIVNAFEEQMVALSDEQLRAKTEEFKARIAKGETLDQLLPEAFAVAREAGKRVMGMRHFDVQLIGGMTLHEGQIAEMRTGEGKTLVGTLAVYLNALSGKGVHVVTVNDYLARRDANWMRPLYEFLGLTVGIVTPFQPPEEKRAAYAADITYGTNNEYGFDYLRDNMAFSMDDKFQRELNFAVIDEVDSILIDEARTPLIISGQAEDSSKLYTEINRLIPKLEQHIEEVEGEVTKPGHFTVDEKTRQVELNEAGHQFIEEMLTEVGLLAEGESLYSAHNLGLLTHVYAGLRAHKLFNRNVEYIVADGQVLLVDEHTGRTMPGRRLSEGLHQAIEAKENLNIQAESQTLASTTFQNYFRLYNKLSGMTGTADTEAFEFHQIYNLAVMVIPPNKPLARKDFNDLVYLTAEEKYAAIVTDIKACIAENRPVLVGTATIETSEHMSNLLKQEGIDHKVLNAKFHEKEAEIIAQAGRPGALTIATNMAGRGTDILLGGNWEVEVANLEDPTPEQIAQIKADWQKRHQQVIEAGGLHVIASERHESRRIDNQLRGRAGRQGDTGSSRFYLSLEDSLMRIFASDRVKNFMKALGMQSGEAIEHRMVTNAIEKAQRKVEGRNFDIRKQLLEFDDVANEQRKVIYHMRNTLLAAENIGETIADFREEVLNNLISQHIPPQSLPEQWNVAGLEAALNTDFAVKLPVQQWLDEDDNLHEDSLREKIMAQLLVAYNEKEDQASAEALRSFEKQILLRVLDDLWKDHLSTMDHLRHGIHLRGYAQKNPKQEYKRESFTLFQELLDSIKRDTIRVLSHVQVRREDPEEEEARLRQEAEELASRMQFEHAPAPGIDQPLLDEEGGEAPVAVASEPVRNDQKLGRNELCWCGSGKKFKHCHGQIN
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: SPSB2_MOUSE
Sequence: MGQTALARGSSSTPTSQALYSDFSPPEGLEELLSAPPPDLVAQRHHGWNPKDCSENIDVKEGGLCFERRPVAQSTDGVRGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQADHYAALLGSNSESWGWDIGRGKLYHQSKGLEAPQYPAGPQGEQLVVPERLLVVLDMEEGTLGYSIGGTYLGPAFRGLKGRTLYPSVSAVWGQCQVRIRYMGERRVEEPQSLLHLSRLCVRHALGDTRLGQISTLPLPPAMKRYLLYK
What is the function of this protein?
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20603330).  Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:20603330).  Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity).
What are the official names of this protein?
SPRY domain-containing SOCS box protein 2, SSB-2, Gene-rich cluster protein C9.
What is the protein family that this protein belongs to?
Belongs to the SPSB family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Note=Exhibits a diffuse cytosolic localization.
Protein: MUTS_HYPNA
Sequence: MPDTARPSATTEPTPFMAQYLSIKAEHPGALLFFRMGDFYELFFQDAVEAASILDITLTSRGEHDGKPIPMAGVPYHAAEGYLARLIKGGCRVAVCEQMETPAEAKKRGSKSIVQRGVVRIVTPGTLTEDALLPARQGQALAAIAFSGAGEAALAVCDVSTGAFDLTAIPAARLGEALLAWPLSELVISADDADRPLILEARGFLSAPITERPGRAATAKSGEALLKEVFGLAALDSLGDFSRVEFAAAGLLLDYVKLTQAGAPIRLRAPRRPDTGGILLIDPATRASLEIDRSISGGRDGTLLAVIDRTVTAPGARLLAARLARPSRSVSEITSRYDAVSHLLGDAGQLEDVRVRLKSAPDLERAVMRLNLGRGGPRDMAALSKAVLSGAEAAGVLGRGLPPRLAEVAETLGLSGAPSVRAFAEDLARALTEAPPMLARDGGFIAQGWDVALDEVRALRDGSRRVIAELQAKYADQTGINALKVKFNNVLGYFIEVPAAKADPMLRAPLSADFIHRQTMAGAVRFSTHELADLAGRIGRAEDEAKAREIAIFEAFCAKVEELTGPLAVIAAALAELDVAASHAVWAAETGAVRPALDPRPVFEAKGLRHPVVEAALRKEGKGFTANDLHLDAEGNEGARFLLVTGPNMAGKSTYLRQSALAVILAQAGAFVPAASLRLGLSDRVFSRVGASDDLARGRSTFMVEMVETAAILNQATPESFVILDEVGRGTATWDGLAIAWAAAEHLHDTNRCRAIFATHYHELTDLAARMPAASNASLKAREWKQDLIFLHEVQPGPADRSYGVQVAKLAGLPRAAVARAGQILKKLEAGPSASENLPLFAMVAEDPAPEFSPESSAVIEALAAADPDSLTPREALDLVYRLKDLSRGA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: AROE_STRZT
Sequence: MKLDGYTRLTAVVANPIKHSISPFIHNRAFEATATNGAYVAWEIEASDLAETVANIRRYQMFGINLSMPYKEQVIPYLDKLSDEARLIGAVNTVVNENGNLIGYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEKTRPYLDKLQEQTGFKVDLCALEYVSELQARIAESDLLVNATSVGMDGQSSPVPENIVLPETLLVADIIYQPFETPFLKWARSQGNPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIWQSLTEKYQ
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: PSBB_AETCO
Sequence: MGLPWYRVHTVVLNDPGRLLSVHIMHTALVAGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWNITGGTITNPGLWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLSGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQPVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSAGLAENPSLSEVWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPVFRNKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFQKLGDPTTKRQAV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RBSD_GLAP5
Sequence: MKKTTILNAQLSHVIATMGHTDGLTICDAGLPIPTEQHCIDLALTKGIPDFLSVLQAVSSELFIEKIVLAEEIKNINPQIEQQLLMVIQQIEVQQKNTIKIEYIPHNEFKHQSNQAKAVVRTGECSPYANVILYSGVPF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_NITHX
Sequence: MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVTGPVEDNMSMLVVAQLLFLEADNPKKEISMYINSPGGVVTSGLAIYDTMQFIRPPVATLCTGQAASMGSLLLAAGEKDMRHALPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNEIYVKHTGQTYKAIEDALERDKFLTADMARDFGLVDKVIDKRAEEPAAPKAS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMR13_CRYX8
Sequence: MGSAIDFDLDGHLDILGQQPLLQMYTQICFAFPVADSSSYSAITKTLADGLERLSASFPWVAGHIVNEDSGEGNTGVFKIKPLDKSPSLIVKDFRNDPSFPTMEAIKKAGFPFSMLNEDIIAPRKTLPVRSDTPEISPVLVVQADLITGGLLLVFAGQHNAMDMTGQGQVIHLFSKACRNEPFTSDELVSGNLDRRTLVPLLDDSYKQGHELARQISQPRPPPSSDGPPPPKLDWTYILFSPTSLAELKSLAQKTITFPSSFISTDDTLSAFVWQAVARSRLPRFDASAKTTCARAVDVRSYLGVPSTYTGLLQNVTYDTFTLQKLVNEPLGSVASALRSGLDPKRPNDLGFSTRALVTVLSRTLDKNTFSFGGTVNPSLDFMVSSWAKLDSYELDFGLGLGKPEGVRRPQFQPLESLGFLMPKTQDGEIAFALCLMEEDMKRLRADEEFTKYGVFVG
What is the function of this protein?
O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of the dimeric xanthones cryptosporioptides (PubMed:30996871).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase dmx-nrPKS (Probable).  The atrochrysone carboxyl ACP thioesterase dmxR1 then breaks the thioester bond and releases the atrochrysone carboxylic acid from dmx-nrPKS (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase dmxR15, and oxidized by the anthrone oxygenase dmxR16 to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by the oxidoreductase dmxR7 (Probable).  A-ring reduction by the short chain dehydrogenase dmxR18, dehydration by the scytalone dehydratase-like protein dmxR17 and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:30996871).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) dmxR6 then yields monodictylactone in equilibrium with monodictyphenone (PubMed:30996871).  In the case of the cryptosporioptides biosynthesis, monodictylactone is reduced at C-12 to an alcohol (by the short chain dehydrogenases dmxR12 or dmxR8) and hydroxylated at C-5 by dmxR9, yielding the electron-rich aromatic which could eliminate H(2)O to form the ortho-quinonemethide, followed by tautomerisation to paraquinone and complete the formal reduction to produce the 10-methylgroup (Probable).  Conjugate addition of C-4a-OH to the resulting paraquinone by the monooxygenase dmxR10 then gives cyclohexadienone, which is then reduced at C-5 by the short chain dehydrogenase dmxR3 to give the dihydroxanthone (Probable).  The 6,7-epoxide in the cryptosporioptides could be introduced by the cytochrome P450 monooxygenase dmxL3 (Probable).  The highly reducing PKS dmxL2 manufactures butyrate, which is further carboxylated by dmxL1 to form ethylmalonate (PubMed:30996871).  It is not yet clear whether the carboxylation occurs while the butyrate is attached to the ACP of dmxL2, but this unusual fungal metabolite could then be esterified to O-5 by the O-acetyltransferase dmxR13 (PubMed:30996871).  Finally, dimerization performed by dmxR5 gives the observed dimers cryptosporioptides A, B and C as the final products of the pathway (PubMed:30996871).
What are the official names of this protein?
O-acetyltransferase dmxR13, Dimeric xanthone biosynthesis cluster protein R13.
What is the protein family that this protein belongs to?
Belongs to the trichothecene 3-O-acetyltransferase family.
Protein: PSAN_MAIZE
Sequence: AMRNAIEGMNGKELDGRNITTTGSAKATIFDEYLEKSKANKELNDKKRLATSGANFARAYTVEFGSCQFPYNFTGCQDLAKQKKVPFISDDLEIECEGKEKFKCGSNVFWKW
What is the function of this protein?
May function in mediating the binding of the antenna complexes to the PSI reaction center and core antenna.
What are the official names of this protein?
Photosystem I reaction center subunit N, chloroplastic, PSI-N.
What is the protein family that this protein belongs to?
Belongs to the psaN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side.
Protein: ARLY_GEOUR
Sequence: MSKDKLWGGRFTQPTDKFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQKIIPMADVEKIVQGLQEILAQIEAGTFDFSISLEDIHMNIESRLSAKIGEAGKRLHTGRSRNDQVALDIRLYLRDELVEISAYLELLIDSLIFQAEKNIDVIMPGYTHLQTAQPILFAHHMLAYVEMFKRDIGRIEDCLKRANVLPLGAGALAGTTFPIDREHVAELLDFPAVTRNSLDSVSDRDFALEFLADASILMMHLSRFSEELILWSTSEFKFIELSDGFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKSLPLAYNKDMQEDKEPLFDTIDTVKGSLKIFADMIREMRVNVATMRQAAAKGFSTATDVADYLVRKGMPFRDAHEVVGKSVAYCIAEKKDLPELSIEEWRSFSDKIDEDIYDAITLEASVNARRATGGTALERVKAEIERAKVGR
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_MAIZE
Sequence: MVKYSQEPGNPTKSAKAMGRDLRVHFKNTRETAFALRKLPLTKAKRYLEDVIAHKQAIPFRRYCGGVGRTAQAKSRHSNGQGRWPVKSARFILDLLKNAESNADVKGLDVDNLYVSHIQVNQAQKQRRRTYRAHGRINPYMSSPCHIELILSEKEEPVKKEADNIVAARKQ
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL15_YERPY
Sequence: MRLNTLSPAEGAKHAPKRVGRGIGSGLGKTAGRGHKGQNSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAMITAEVRLSELALVEGDVIDLNTLKAANVVGIQMEFVKVILSGEVNRAVTLRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RHAD_YERPP
Sequence: MQAILSSWFIQGMIKATSDMWHKGWDERNGGNISLRLLAEEVEPYRRDFYQQPRKVELTQPAPELANSWFLVTGSGKFFRNVELNPAENLVLLQVSNDGMAYHIHWGLTQGGLPTSELAAHFQSHIVRMQVSGGTNRVIMHCHATNLIALSYVQKLENASFTRLLWEGSTECLVVFPDGIGIVPWMVPGTDGIGTQTAEQMREHSLVLWPFHGIFGSGPTLDDAFGLIDTAEKSAEIMVKVLSMGGKKQTISREQLIALAARFDVTPMAAALDA
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPD_BURL3
Sequence: MSQQLQQIIDTAWENRAELSPKAAPADVREAVAHAIEQLDKGALRVAEKIDGNWTVHQWLKKAVLLSFRLEDNAPMPAGGYSQFYDKVPSKFANYTAEDFAAGGFRVVPPAIARRGSFIAKNVVLMPSYTNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPVIIEDNCFIGARSEVVEGVIVEENSVISMGVYLGQSTKIYDRETGEVSYGRIPAGSVVVAGNLPSKDGSHSLYCAVIVKKVDAKTRAKVGLNELLRGD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_RHOOB
Sequence: MTSPVGLGMPEGPAAVLAPRRKTRQLQVGSVGVGSDFPVSVQSMCTTKTHDVNATLQQIAELTASGCDIVRVACPRQEDADALATIAKKSQIPVIADIHFQPRYIFAAIEAGCSAVRVNPGNIKEFDGRVKEVAKAAGDAGIPIRIGVNAGSLDPRLMQKYGKATPEALVESALWEAGLFEEHGFGDIKISVKHNDPVIMVEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLAEGIGDTIRVSLSAPPAEEIKVGTQILQSLNLRPRKLEIVSCPSCGRAQVDVYTLADEVTAGLEGMEIPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGKVIKTVPEAQIVETLIEEAMRIAEEMEGDSTTGSPVVTVS
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: METE_THEYD
Sequence: MKIKTTVFGYPRIGPKRELKKALEDYWNWKISKVELLETANSLIIQNAKVIQSSGVDLIPSNEFSLYDFILDHSVMFNAVPKRFNRISDPLDRYFAMARGTQELPALEMTKWFNTNYHYIVPEIEDEEFELMENKPLREFALLRDSLSVKTKPVIVGPFTYLKSAKLNMDRVERLSEKILPAYKKLLIKLDAAGVEEIQIDEPAMVMDMEEREIELLTGLYRELTKGLTLKVYIQTYYEAVSAYEKLVFSLSVHGFGFDLVDGKENLENILTLGFPSDKVLIAGVVSGRDPWRTDFTVVMSMLERLFRVTDKIMLSNSSPLIHLPITVEAERGHIQEDILNMLSFANERLEELTILKRAINDGAALPARKSIVHEIFSKAEVRSKISSIDEKAILRKPEFQERYRMQMDSLKLPLFPTTTIGSFPQTKEVRKFRADYKNGKITEEEYKKFIFQEIEKAVKIQEELDIDVLVHGEFERTDMVEFFAEKLKGFAITKNGWVQSYGSRCVRPPVIYGDVWRDKALTVEETLYAQSLTPRPVKGIMTGAVTILQWSYPRKDISRREIAYQIALALKEEVLELEKRGIKIIQIDEPAFREGLPLKRNKQDEYFDWTINSFRLTTADVSPFTQIHTHMCYSDFNEIIDRIYALDADVISIEASRSKGEILSAFENFRYDHGIGLGVYDIHSPRVPSVEEMIEIIERSVSLIDKSLFWINPDCGLKTRGWQETVASLKNMVLAAKAMRKREV
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: NAL12_MOUSE
Sequence: MLPSTARDGLYRLSTYLEELEAGELKKFKLFLGIAEDLSQDKIPWGRMEKAGPLEMAQLMVAHMGTREAWLLALSTFQRIHRKDLWERGQGEDLVRVTPNNGLCLFESQSACPLDVSPNAPRKDLQTTYKDYVRRKFQLMEDRNARLGECVNLSNRYTRLLLVKEHSNPIWTQQKFVDVEWERSRTRRHQTSPIQMETLFEPDEERPEPPHTVVLQGAAGMGKSMLAHKVMLDWADGRLFQGRFDYVFYISCRELNRSHTQCSVQDLISSCWPERGISLEDLMQAPDRLLFIIDGFDKLHPSFHDAQGPWCLCWEEKQPTEVLLGSLIRRLLLPQVSLLITTRPCALEKLHGLLEHPRHVEILGFSEEARKEYFYRYFHNTGQASRVLSFLMDYEPLFTMCFVPMVSWVVCTCLKQQLESGELLRQTPRTTTAVYMFYLLSLMQPKPGTPTFKVPANQRGLVSLAAEGLWNQKILFDEQDLGKHGLDGADVSTFLNVNIFQKGIKCEKFYSFIHLSFQEFFAAMYCALNGREAVRRALAEYGFSERNFLALTVHFLFGLLNEEMRCYLERNLGWSISPQVKEEVLAWIQNKAGSEGSTLQHGSLELLSCLYEVQEEDFIQQALSHFQVVVVRSISTKMEHMVCSFCARYCRSTEVLHLHGSAYSTGMEDDPPEPSGVQTQSTYLQERNMLPDVYSAYLSAAVCTNSNLIELALYRNALGSQGVRLLCQGLRHASCKLQNLRLKRCQISGSACQDLAAAVIANRNLIRLDLSDNSIGVPGLELLCEGLQHPRCRLQMIQLRKCLLEAAAGRSLASVLSNNSYLVELDLTGNPLEDSGLKLLCQGLRHPVCRLRTLWLKICHLGQASCEDLASTLKMNQSLLELDLGLNDLGDSGVLLLCEGLSHPDCKLQTLRLGICRLGSVACVGIASVLQVNTCLQELDLSFNDLGDRGLQLLGEGLRHQTCRLQKLWLDNCGLTSKACEDLSSILGISQTLHELYLTNNALGDTGVCLLCKRLRHPGCKLRVLWLFGMDLNKKTHRRMAALRVTKPYLDIGC
What is the function of this protein?
Plays an essential role as an potent mitigator of inflammation (PubMed:26521018, PubMed:30559449).  Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:30559449).  Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449).  In turn, promotes bacterial tolerance (PubMed:30559449).  Inhibits also the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (By similarity).  Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (PubMed:30212649).
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, PYPAF7.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_MYCTA
Sequence: MTETTPAPQTPAAPAGPAQSFVLERPIQTVGRRKEAVVRVRLVPGTGKFDLNGRSLEDYFPNKVHQQLIKAPLVTVDRVESFDIFAHLGGGGPSGQAGALRLGIARALILVSPEDRPALKKAGFLTRDPRATERKKYGLKKARKAPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: ZAPD_PECAS
Sequence: MSDASSTILFEYPLNEKTRTWLRIESLSQQLHQNHSLTDMGSALTFFRAIAELLDVLERGDVRTELLKELERQQQKLLQWSDVPGVDMERIHSLRRQLKDLSSTLMAAPRMGQFLREDRLIGMVRQRLGIPGGCCSFDLPTLHSWLHQPKELREQLVFSWLNSLSPLKQALDMILELIRHSGTFRPQTSLNGFFQDNASDADLLRLRLEQMHQLYPQISGHKTRYAIRFLPLDSENGHIPPRLTFELACC
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: SYW_HELPY
Sequence: MHKKRVFSGIQPTGQIHLGNYLGAIKHWVEMQDEYENLFCVVNSHAITLPIDPAFLKSQSYELVKLLLACGIDPKQSGLFIQSEVDEHPALAWLLNCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNIAEKFNRDFGNCFKVPEPLIAKVGARVMGLDDPKVKMSKSHQGANHAIFLLDEPDIIVKKIKKAATDSMGVIAFDEKREGIFNLLNIYMLLSNESPENIEERFKNKGYGDFKKELAEVMIQALKPIQERYKEISDDEVKAILNGGAEKARPLARATYQKAKELMGLI
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_IPOSE
Sequence: MRINPTTSGSEVSAVEKKNLGRIVKIIGPVLDVAFPPGKMPNIYNALVVQGRGNEQTNVTCEVQQLLGNNRVRAVAMSDTDGLMRGMEVIDTGAPISVPVGGSTLGRIFNVLGQPVDNLGPVDTNTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYLEMKESGVINEENIPESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNEQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGEEHYETAQRVKQTLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFQLILSGELDGLPEQAFYLVGNIDEATAKAMNLKT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: Y3182_BACAC
Sequence: MRIKARIGVENSLTDVQQALKQQGHEVVTLNSEQDAQGCDCCVVTGQDSNMMGIADASIKGSVITAHGLTTDDICQQVESRT
What are the official names of this protein?
UPF0180 protein BAMEG_3182.
What is the protein family that this protein belongs to?
Belongs to the UPF0180 family.
Protein: FMT_COXBN
Sequence: MSLKIVFAGTPQFAVPTLRALIDSSHRVLAVYTQPDRPSGRGQKIMESPVKEIARQNEIPIIQPFSLRDEVEQEKLIAMNADVMVVVAYGLILPKKALNAFRLGCVNVHASLLPRWRGAAPIQRAILAGDRETGISIMQMNEGLDTGDVLAKSACVISSEDTAADLHDRLSLIGADLLLESLAKLEKGDIKLEKQDEASATYASKIQKQEALIDWRKSAVEIARQVRAFNPTPIAFTYFEGQPMRIWRATVVDEKTDFEPGVLVDADKKGISIAAGSGILRLHQLQLPGKRVCSAGDFINAHGDKLIPGKTVFG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: D3_CAMPM
Sequence: MDIFIVKDNKYPKVDNDDNEVFILLGNHNDFIRSKLTKLKEHVFFSEYIVTPDTYGSLCVELNGSSFQHGGRYIEVEEFIDTGRQVRWCSTSNHISEDIPEDIHTDKFVIYDIYTFDSFKNKRLVFVQVPTSLGDDSYLTNPLLSPYYRNSVARQMVNDMIFNQDSFLKYLLEHLIRSHYRVSKHITIVRYKDTEELNLTRICYNRDKFKAFAFAWFNGVLENEKVLDTYKKVSDLI
What is the function of this protein?
Late protein which is part of a large complex required for early virion morphogenesis.  This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions (By similarity).
What are the official names of this protein?
27 kDa core protein.
What is the protein family that this protein belongs to?
Belongs to the chordopoxvirinae D3 family.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: Y149_ARCFU
Sequence: MVFAYVLVSGFMLVLGIKYGRTKIYSVWKAGLIILAGFAVIFAAAWIAFTGTSASQERIGLAKSLSVVMGLIAGVLSVYVLSKS
What are the official names of this protein?
Uncharacterized protein AF_0149.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.