PharMolix/UniProtQA huggingface dataset:
Protein: UCR9_EUGGR
Sequence: MQTHVRRVALQALRPCLRAGLMAPKFPVRFATTAVSGELLTKTPYTRPGYAAQWTCLVVLFLKNQLLMRLFFAFVAYVVAMKVFGARFHVDHDEDATPAE
What is the function of this protein?
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
What are the official names of this protein?
Ubiquinol-cytochrome-C reductase complex subunit IX, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: RRF_MANSM
Sequence: MINEIKKDTQDRMEKSLEALKGHIAKIRTGRAQPSLLDAIQVDYYGSATPLRQLANVVAEDARTLAVTVFDRSLIQAVEKAILTSDLGLNPSSAGTTIRVPLPPLTEERRRDLIKIVKGEGEQGKVAIRNVRRDANDKIKALLKDKEISENDQRKAEEEIQKITDSYIKKVDEVLAEKEKELMDF
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_CORDI
Sequence: MSTKPSNVVFNIDEEFGITEAIATIDNGDFGKRTIRFETGQLARQADGSVTTYLDDDTMLLATTTASNQPREGFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTEAILACRLIDRPLRPTFVKGLRNEVQVVITVLSVNPQDMYDVVAINGASAATQLSGLPVSGPVGGVRMALIADDAHPKGQWIAFPTHEQHEQALFELVVAGRIVSKKQGKKTVDDVAIMMVEAGATEQVVDRVKAGAPAPTESVVAEGLEAAKPFIEVLCRAQAGLAERAAKETQEFPLFPPYTDVVYDAVEKKVSKKLRSLLTIKSKQDRDEATNAYMEEIEADLIAQLGSDDEAAASKAIRAAYNAVMKKIVRHMILTEHFRIDGRGVTDIRDLGVEVDLIPRAHGSSLFERGETQILGVTTLDMLKMEQQIDSLTPATSKRYIHHYNFPPYSTGETGRVGSPKRREIGHGALAERALVPVIPSREEFPYAIRQVSEALGSNGSTSMGSVCASTLSLYNAGVPLKAPVAGIAMGLVSDEVDGETRYVALTDILGAEDAFGDMDFKVAGTRQFITALQLDTKLDGIPSEVLAQALSQANDARNTILDTMAEVIETPDEMSDYAPRITAITVPVNKIGEVIGPKGKTINSITEETGANISIEEDGTVYVSAASGAAAEAAIEKINAIANPQLPKVGERFLGTVVKTTAFGAFVSLLPGRDGLVHISKLGGGKRIEKVEDVVNVGDKLEVEILDIDNRGKISLAPVKNED
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_THESQ
Sequence: MKYFGTDGIRGIFGETLTDELAFKVGKALGEIVGEGRVIVGKDTRVSGDSLEAAISAGLTSMGVDVLLCGIIPTPAVALLTRITRSFGVVISASHNPPEYNGIKVLKGGYKIPDEMEAEIEERLENGSFPPRLVVGRTKSFREGRDMYIGAVLEIFRDLDLTGEMVSLDLANGATTTTAKEVFEFLGAKVEVFNDSQDGLLINQGCGATHPRFLAEEMKNGKVGFTFDGDGDRVIAVDEERNVVNGDRIIGILAVGLKEEGRLNSDTVVGTVMTNGGLEDFLKEKGIKLLRTKVGDKYVLEKMLESGANLGGERSGHIIILDRSTTGDGLITALELMRVLRRSGRNLSDFAKEIPDYPQITKNVRRTERMSLENENLRKIVEESTSRGYRVVIRPSGTEPVIRITVEGKDREEIEKIVEEISRVLES
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RRF_METC4
Sequence: MATPEFDLGDIKRRMQGAVSSLSKDLGSLRTGRATPSLLDPIQVEAYGSSMPMAQVATVSVPEPRLLSISVWDRSMVTNVEKAIRESDLGLNPMTEGQTIRLRIPEMNEQRRKEMVKVAHKYTEEARVAVRHVRRDGLDILKKLEKDGAISQDDEKRQAAEVQKATDDAINEIDGVLASKEKEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIS4_SCHPO
Sequence: MNVNSSAFERTNRFPSFPVLKDDQKTSSDSIAAAKKKDLLSLISSKSLLSSETLGWFSVICAFSITGSGLEVNTMSIPFYLIFGIFAFVSFTTQYLGIYSFSFQPFQLLNVIIASLSMVFITLGAFVLGTLDTTCLLLLAFKLFFIRNDPTPFNARSANLKNYIAFPICLFVINHILILLGYFQCSYSVFYASVFYILLGVFIRVFYLVNKEKFEKKELAFLFSSIVVACLIQFNVLPLGTINLSVTRFTILCFMQIFCINWDGIARIQFYLGKFDISLIMALISAIINKTASQNSIKIISCLYQVGFCFFKIGSSITANLKLPDNSRIYRLYNDFIVNGVLADKESRSIFYFFLLNVSYMFVQVIYGLWTNSLGLISDAIHMAFDCIAILVGLVATTLAKMPLNYAYPFGFAKIEALSGFTNGIFLVLISFSIVGEALYRLFHPPQMNTDQLLLVSFLGLVVNLVGILAFNHGHNHDHGSHHHHSHSNHSMCLPNTTNDINIFEEFEEEKDNVEAQKMGYTNDDHVSQHEHTHENSQEHHHEHNHNHDHIHKYNEKCDHESISLQNLDNDHHCHHHHENHNMHGIFLHIIADTMGSVGVIVSTILIQWFSWTGFDPLASLIIAALIFVSVLPLIKDSAKNLLSVTDPESEYLLKQCLSNISLSNSVISLSNPKFWTNERGEVYGILHIQVSIDGDLNVVRNEVFRKLSIAVPNLKHICIQSERPNNCWCGK
What is the function of this protein?
Probable zinc transporter involved in Golgi membrane trafficking through the regulation of zinc homeostasis.
What are the official names of this protein?
Probable zinc transporter cis4.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi- pass membrane protein.
Protein: MED8_ASPOR
Sequence: MATPTQEQLKTLEQSRQRLVQLTRSLASLITSLNQSDPLPSWSSLQSQASIISNNLLSVSDHLSDNRDLLTSLVAYPGPDYPGRTQANTLEQLLRTKLDPRVEDWVARGRKAGASALEDKSGLAEAELAELWDWAPVEANQEARRRNWGGNFTLEEREMGVQNVVTGLARVLEDEGSESEDEEEGEEDEMEIVGVRRQSAGAGFEFDIAPASAAQHQQQKFVEPAVPLEDILRFMTTGAEPGKR
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 8, Mediator complex subunit 8.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 8 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METK_TROWT
Sequence: MILTSESVTEGHPDKLCDQISDAILDGVICKDKNARAGIETIAGNGVVHVFGEVSNPDSVDIPGIIRKTILDIGYTSEDAGIDGNTCSIQESITSQSKEIADAVNFSLEYRNQQGDLGRNSFSQQGSGDQGSVFGYACRETPEMMPLPITIAHKLAYSLAFVRKEKILPYLLPDGKSQVTLGYDSANRPKTLETVVISAQHEDSVDLDKLRFDILERVVRPVISATGLDCSKATFLINPAGRFVTGGPSADSGLTGRKIVVDTYGCAAKHGGGALSGKDPSKLDRFASYMARWVAKHVVAADFAESIEVQISYAIGKAHPVAFNIDTHGTNTIALDKLKRAILKVFDFRPAAVIDSLDLKRPIYQKTAAYGHFGRDIFTWERICPDKLNALLGAV
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_MYCA9
Sequence: MTGGEQKPNEIIGVRRGLFGVRGSGDTSGYGGLVQPISLPVSSNRPYGGYFDQVVDRLESVLAEQENVTYADAVEGVVVYRDQLTIHVKAEHLVQVAQSLRDDPQLRFELSLGVSGVHYPDDSARELHAVYPLMSITWNRRIMLEVAVPESDPHIPSLNAVYPTTDWHERETYDFFGIIFDDHPALTRIQMPDDWDGHPQRKDYPLGGVPVEYHGATIAPPDQRRSYN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ENV_BIV29
Sequence: MDQDLDGAERGERGGGSEELLQEEINEGRLTAREALQTWINNGEIHPWVLAGMLSMGVGMLLGVYCQLPDTLIWILMFQLCLYWGLGETSRELDKDSWQWVRSVFIIAILGTLTMAGTALADDDQSTLIPNITKIPTKDTEPGCTYPWILILLILAFILGILGIILVLRRSNSEDILAARDTIDWWLSANQEIPPKFAFPIILISSPLAGIIGYYVMERHLEIFKKGCQICGSLSSMWGMLLEEIGRWLARREWNVSRVMVILLISFSWGMYVNRVNASGSHVAMVTSPPGYRIVNDTSQAPWYCFSSAPIPTCSSSQWGDKYFEEKINETLVKQVYEQAAKHSRATWIEPDLLEEAVYELALLSANDSRQVVVENGTDVCSSQNSSTNKGHPMTLLKLRGQVSETWIGNSSLQFCVQWPYVLVGLNNSDSNISFNSGDWIATNCMHPITLNKSAQDLGKNFPRLTFLDGQLSQLKNTLCGHNTNCLKFGNKSFSTNSLILCQDNPIGNDTFYSLSHSFSKQASARWILVKVPSYGFVVVNDTDTPPSLRIRKPRAVGLAIFLLVLAIMAITSSLVAATTLVNQHTTAKVVERVVQNVSYIAQTQDQFTHLFRNINNRLNVLHHRVSYLEYVEEIRQKQVFFGCKPHGRYCHFDFGPEEVGWNNSWNSKTWNDLQDEYDKIEEKILKIRVDWLNSSLSDTQDTFGLETSIFDHLVQLFDWTSWKDWIKIIIVIIVLWLLIKILLGMLRSCAKVSQNYQHLPAEEEDGDTEPESSPARGDPASGSLYENWLNKIGESKNDAYRVWTEEYNSLRILFATCRWDLLTPQLLQLPFFLLTLLLKLLWDIFRHAPILNLKGWTVGQGGTSGQQQPPDFPYVNWTGSREQNNPEGGLDSGAWYEGLRGSQ
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: RL25_HELP2
Sequence: MLEGVIRESITKANAKALKKDGYLIANVYGKGIENVNCAFKLNPFIKYLKEKKHLIFPVKLGDKTFEVVVQEYQKNPVTNELIHVDLLAVTKGVKSKFKVPVKHQGTPVGLKNKGILMLSKKRISVECAPEHLPDHYLVDVAPLDVNESVLVRDLEKHENVKILDHDSIAVIGVIKAK
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: WHIA_BACAA
Sequence: MSFASETKKELTNLEMKECCEKAELSALLRMNGSLSFSNRRLSIDIQTENAAIARRIYTLLKKGYDVTVELLVRKKMRLKKNNVYIVRLVEKSREILADLHIVRDDFSFIRNISQELIEKKCCKRSYLRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDAICELMNGFDLNSKTLERRKGYITYLKEAEKITEFLNIIGAHNALLRFEDIRIVRDMRNSVNRLVNCETANLNKTIGAALRQIENIRYIDETVGLDILPDKLREIAQLRRDYQDVTLKELGEMVSGGKISKSGINHRLRKIDDIAEKLRAGETVAKK
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: SHE10_YEAS7
Sequence: MGKLIKLITTLTVLVSLLQYCCEFNSGSISCERTQTLCHYTNPRVWNTYFSRNCELYKNKVSPGFDIVARKYDTAVKPVIDDATVKVNKVAIQPAFKVIHSQCKKWNCGKYYQLVRSPMVKTRRFFFAKYNAFVKPNLDKFFTAEFRSHLKERILKYKNIGHYYFTITSRCIKSKYDFIVGNTEEKLMGKFKNKDTHGIHGSVTREPSSEDMVLTVSTMESDEEELTTTSTQTVVETITLDQEEASAVANHAHDDEASTDVEGSTDVNVNEQALLQEDFDMWSETILQKTQDVIQLFEKDVSKYINGKLVEEANHFKAKFQSLDDKSKKFFSKISLAINDIECVEGIDSETGKKIFFDKSGSTEISQYITRELVREYFNETRSTLDELTNAMEKDLSEITDEIEKKVNAIREENVEVFEEWGDIIVNEWSKRMAYVDVINAHMGADDDTTLDEEKAKSSVNWKKFLKGKKQIIESRDKLAHHSADLSRVNAFRQKVQKKILSFTQESGEFLYILRSKANLQFQERERKERERKEREKAAAEEFQRQQELLRQQEEEDEEDVSYTSTSTITTTTTMTL
What is the function of this protein?
Involved in spore wall assembly.  May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria.
What are the official names of this protein?
Outer spore wall assembly protein SHE10, Sensitivity to high expression protein 10.
What is the protein family that this protein belongs to?
Belongs to the SHE10 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DAPE_ECOL6
Sequence: MSCPVIELTQQLIRRPSLSPDDAGCQALLIERLQAIGFTVERMDFADTQNFWAWRGQGETLAFAGHTDVVPPGDADRWINPPFEPTIRDGMLFGRGAADMKGSLAAMVVAAERFVAQHPNHTGRLAFLITSDEEASAHNGTVKVVEALMARNERLDYCLVGEPSSIEVVGDVVKNGRRGSLTCNLTIHGVQGHVAYPHLADNPVHRAAPFINELVAIEWDQGNEFFPATSMQIANIQAGTGSNNVIPGELFVQFNFRFSTELTDEMIKAQVLALLEKHQLRYTVDWWLSGQPFLTARGKLVDAVVNAVEHYNEIKPQLLTTGGTSDGRFIARMGAQVVELGPVNATIHKINECVNAADLQLLARMYQRIMEQLVA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: YIS1_SHISO
Sequence: MSRKTQRYSKEFKAEAVRTVPENQLSISEGASRLSLPEGTLGQWVTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATAYFAQESLKNTR
What are the official names of this protein?
Insertion element IS600 uncharacterized 11 kDa protein, ISO-S3 11 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: SYA_STRPB
Sequence: MKELSSAQIRQMWLDFWKSKGHCVEPSANLVPVNDPTLLWINSGVATLKKYFDGSVIPENPRITNAQKSIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAIEWGFELLTSPDWFDFPKDKLYMTYYPDDKDSYNRWIACGVEPSHLVPIEDNFWEIGAGPSGPDTEIFFDRGEDFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPNKNIDTGAGLERLAAVMQGAKTNFETDLFMPIIREVEKLSGKTYNPDGDNMSFKVIADHIRALSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINETFLYKLVPTVGQIMESYYPEVLEKHDFIEKIVKREEETFARTIDAGSGHLDSLLAQLKAEGKDTLEGKDIFKLYDTYGFPVELTEELAEDAGYKIDHEGFKSAMKEQQDRARAAVVKGGSMGMQNETLAGIVEESRFEYDTYSLESSLSVIIADNERTEAVSEGQALLVFAQTPFYAEMGGQVADTGRIKNDKGDTVAEVVDVQKAPNGQPLHTVNVLASLSVGTNYTLEINKERRLAVEKNHTATHLLHAALHNVIGEHATQAGSLNEEEFLRFDFTHFEAVSNEELRHIEQEVNEQIWNALTITTTETDVETAKEMGAMALFGEKYGKVVRVVQIGNYSVELCGGTHLNNSSEIGLFKIVKEEGIGSGTRRIIAVTGRQAFEAYRNQEDALKEIAATVKAPQLKDAAAKVQALSDSLRDLQKENAELKEKAAAAAAGDVFKDVQEAKGVRFIASQVDVADAGALRTFADNWKQKDYSDVLVLVAAIGEKVNVLVASKTKDVHAGNMIKELAPIVAGRGGGKPDMAMAGGSDASKIAELLAAVAETV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRF2_XENLA
Sequence: MSGAKRCPDCGSSEIVEDAHYSQDQLVCADCGCILSEGLITTTVSEETSLQAVRYSDSTGENDSVTYCMKRGIIRVRDLCRVLRLPDGFVDTALSYYKQAVGLPLYRLVSIEKKEIIVGCCVYITCRQQQWPITMGTICSLIYAKKELFASLFMDIVQVLKVDVPSISLQNLVKSHCRSFKLFKDSSEVPPQYAEKLDTVSERTVQTVELAYETWLVTGRHPIPMITAAAYISWQSFQPSRRLSCSLSRFCKLSDVDMPPPSTIRLKELQETLIKLAYHLPWLKILSLNRKNIVQHLGDLLKHRALLLRRALAVTEAELSKGTEASSSTDQLNSTLVFLPPCVSNPKKRSRSIAFPCGDLDITGDEEISDSEIEQYLRTPAEMKDYQQVQSCISSV
What is the function of this protein?
General activator of RNA polymerase III transcription.  Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites.  Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress.  Down-regulates expression of target genes in response to oxidative stress.  Overexpression protects cells against apoptosis in response to oxidative stress.
What are the official names of this protein?
Transcription factor IIIB 50 kDa subunit, B-related factor 2, BRF-2.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: WASH2_HUMAN
Sequence: MTPVRMQHSLAGQTYAVPLIQPDLRREEAVQQMADALQYLQKVSGDIFSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPGIANDLMYIADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPSVQGAPREVVDPSGGRATLLESIRQAGGIGKAKLRSMKERKLEKKKQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGEGPGGAFARVSDSIPPLPPPQQPQAEEDEDDWES
What is the function of this protein?
Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.  Involved in endocytic trafficking of EGF.  Involved in transferrin receptor recycling.  Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration.  In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function.  In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation.  Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling.  Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex.  Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).
What are the official names of this protein?
WAS protein family homolog 2, CXYorf1-like protein on chromosome 2, Protein FAM39B.
What is the protein family that this protein belongs to?
Belongs to the WASH1 family.
What are the subcellular locations of this protein?
Early endosome membrane. Recycling endosome membrane. Late endosome. Cytoplasmic vesicle, autophagosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2.
Protein: TFR1_CANLF
Sequence: MMDQARSAFSTLFGGEPLSYTRFSLARQVDGDNSHVEMKLAADEEENVDNNMRGNHASVPKPKRCNGFICYGTIAVVLFFLIGFMIGYLGYCKRVEPKAGCERPTGTEALGTERTEPSETEEYFPETPSRLFWTDLKTMLSERLSNTDFTNTMRWLNENSYVPREAGSQKDESLALLIENRFREFQLSKSWRDEHFVEIQVKSSNAQNTVTIVDMESDLVYLAESPEGYVAYSKATTVTGRLVHVNFGTKKDFENLKSPVNGSLVIARAGKITFAEKVANAQSYNALGVLIYMDQARFPIVNARIPFFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPSIPVQTISRAAAEKLFENMEGDCPSAWEIDPSCRLETSSNKNVNLTVNNVLKEIRIFNVFGVIKGFEEPDRYVVIGAQRDAWGPGAAKSSVGTALLLELARIFSDMVLKGGFKPSRSIVFASWSAGDFGAIGATEWLEGYLSSLHLKAFTYINLDKAILGTSNFKVSASPLLYSLLEKTMKDVKHPITGQSLYRDSNWINKVEKLSLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDLYENLNQKIPQLNKMARGAAEVAGQLIMKLTYDLELNLNYEMYNDRILSFVRDMNQFRTDIKEMGLNLQWLYSARGDFFRATSRLTTDYKNAERTNRFVMREINDRIMKVEHNFLSPYVSPRDSPFRHIFWGSGSHTLPALVEHLKLRQKNKSAFNETLLRNQLALATWTIQGAANALSGDIWDIDNEF
What is the function of this protein?
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity).  Endosomal acidification leads to iron release.  The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.  Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).  Positively regulates T and B cell proliferation through iron uptake (By similarity).  Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity).  When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity).  When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
What are the official names of this protein?
Transferrin receptor protein 1, TR, TfR, TfR1, Trfr.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Melanosome.
Protein: TMEDE_DROSE
Sequence: MRDQFISLALILCVLHSACGLYFHISETERKCFIEEVPDETTVIVNYKVELYDPRSNGFMPSSPGIGMHVEVRDSDDKIVLSRVYSSQGRISFTSHTPGEHVICMFSNSTAWFSGAQLRVHLDIQVGEHAIDYANVAQKEKLTELQLRIRQLLDQVEQITKEQNYQRYREERFRHTSESTNSRVLWWSLAQTIVLVCMGFWQMRHLKSFFEAKKLV
What is the function of this protein?
Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo.  Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.  Involved in Golgi organization (By similarity).
What are the official names of this protein?
Transmembrane emp24 domain-containing protein eca.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: PGLRX_ASPFN
Sequence: MKLTQATTLLLSLGLSLPVEGFSLSRTNAVGPKPPFRPLPASTPRNKTCQVQSNGDGTDDAPYILAALKQCNNGGKVVFAEDKEYTIGTALDMTFLKHVDLEILGKITFTPDTDYWQENSFKHTFQNATTFFNLGGTDVNVYGGGELNGNGQVWYDLYAEDALILRPILVGIIGLHGGTIGPLKLRYSPQWYQLVANSSDVLFDGIDISGYSSSENEAKNTDGWDTYRSSNIVIQNSVINNGDDCVSFKPNSTEILVQNLHCNGSHGISVGSLGQYQGEVDIVQNVLVYNISMYNASDMARIKVWPGISSAMSEDLQGGGGLGSVQNITYDKMYIENVDWAIEVTQCYGQKNQTLCNENPSNLTISDVYFNDLTGVTSGKNDPNVGTIICSSPDVCSGIHATNIDVKSPDGDSGFVCTNVDEEFLDVECASSS
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Probable exopolygalacturonase X, ExoPG, Galacturan 1,4-alpha-galacturonidase, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.