PharMolix/UniProtQA huggingface dataset:
Protein: PP1R7_ARATH
Sequence: MNSEKEDEPLEEIGDSNNVLDLTSYQLHSLDTVELPPNLIELDLTANRLSGLDSRIAQLSTLKKLSLRQNLIDDSAVEPLSHWDALSDLEELVLRDNKLAKVPDVSIFTKLLVYDISFNEITSLEGISKASSTLKELYVSKNEVNKIMEIEHLHNLQILELGSNRLRVMENLENFTKLEELWLGRNRIKVVNLCGLKCIKKISLQSNRLTSMKGFEECVALEELYLSHNGISKMEGLSALVNLRVLDVSNNKLTSVDDIQNLTKLEDLWLNDNQIESLEAITEAVTGSKEKLTTIYLENNPCAKSSDYVAAVRQIFPNVEQIDSNLFA
What is the function of this protein?
Inhibitor of protein-phosphatase 1 (PP1).  Binds to and inhibits PP1 activity.
What are the official names of this protein?
Protein phosphatase 1 regulatory inhibitor subunit PPP1R7 homolog.
Protein: VPR_HV1Y2
Sequence: MEQAPEDQGPQREPHNEWTLELLEELKREAVRHFPRPWLHGLGQHIYETYGDTWAGVEAIIRILQQLLFIHFRIGCQHSRIGIIQQRRARRNGASRS
What is the function of this protein?
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus.  This function is crucial for viral infection of non-dividing macrophages.  May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: Y879_PSEFS
Sequence: MRLIIVSGRSGSGKSTALNVLEDNGFYCIDNLPAGLLPELAERALIHTELAQPLVAVSIDARNLPSHLERFPQLLEEVRAKHIHCDVLYLDADEETLLKRFSETRRRHPLSSPHRSLAEAIEDETKLLGPIIDLADLKINTTSLNLYQLRDAIKLRLLNQPEPGTAFLVESFGFKRGMPVDADLVFDVRCLPNPYWKPELRDQSGLDQPVADYLAAQPDVEEMFQDISSYLLKWLPRFAASNRAYVTIAIGCTGGHHRSVYLTERLGQVLQKTLKNVQVRHRDLS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein PFLU_0879.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: C3H49_ARATH
Sequence: MMIGETRRTYPTVEIPPWPVLEELTTSEFFSPVMNSPDCSMLEALAGLQRYLPSNEPDPESYPDLLGPDSPIDAYSCDHFRMYDFKVRRCARGRSHDWTECPYAHPGEKARRRDPRKYHYSGTACPDFRKGGCKKGDSCEFAHGVFECWLHPARYRTQPCKDGGNCLRKICFFAHSPDQLRFLHTRSPDRVDSFDVSSPIRARAFQLSISPVSGSPPMSPRADSESSPMTQSLSRSLGSCSINDVVPSFRNLQFNSVKSFPRNNPLFGFGSPRGSILGPGFQSLPTTPTRPGNLDIWEYGLEEEPVMERVVESGRELREKMREKLHKENCMDRVAQDPDQNLGEAPDVGWVSDLLM
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 49, AtC3H49.
Protein: BPPDD_BOTJA
Sequence: QGRAPHPPIPPAP
What is the function of this protein?
This peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it.  It acts as an indirect hypotensive agent (By similarity).
What are the official names of this protein?
Bradykinin-potentiating peptide 13d, BPP-13d.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-potentiating peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISCS_HAEDU
Sequence: MKLPIYLDYAATTPMDERVVQKMMQYMTKDGIFGNPASRSHKFGWEAEEAVDIARNHIADLIGADSREIVFTSGATESDNLAIKGAAHFYQTKGKHIITLKTEHKAVLDTCRQLEREGFEVTYLEPESDGLLDLTKLVEAIRPDTILISIMHVNNEIGVVQDIKAIGEICRARKIIFHVDATQSVGKLAVNVQELKVDLMSFSSHKLYGPKGIGGLYVCRKPRIRIEAIIHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMPRLKALRDRLYHGFQAIEEVYVNGSMEEGKRVDTNLNMSFNFVEGESLMMALRDIAVSSGSACTSASLEPSYVLRAIGRNDELAHSSIRFSLGRWATEEEIDYTIELVKKSILKLRELSPLWEMFKEGIDLSKIEWNHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHA3_BOMMO
Sequence: GGGWNGWNGLGGGWNGLGVGWSRLDGGYGGGCGSYGGEGIGNVGVADELPVGGVTAVGGRVPIIGGVEYGGPARAAGAVSICGHCAPTCGCGRAGLGGYY
What is the function of this protein?
This protein is one of many from the eggshell of the silk moth.
What are the official names of this protein?
Chorion class A protein M2774.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: TPS9_DICDI
Sequence: MYSLHDFKFPEDWIEPPANDKCIYTCYKEVVDFKLFEENKKTLEYYYGTISSTIYLYPLCNYEQLLVASRYLTVCFVVDDFLESKLTNPDDSRELIKKLEHIFMDGNFYDSNNISNIEKYVLYFRETTKQFVGEKIEFFNQFLKFIIDWINSINPFNRADNLNNYDSYNFFKRTNSGTYVSLSVAMLLYPNSKIDPKIWINPRFDRFATNGGYQMATMNDCASYAKEIRNNNHLTNPLHFLQNQVGSFDNVYKVILKFNDEIMNQICEDERILLLECPIEQRDDLKLLTRSMKLILGGNYLWSLQCSRYVDINSPFIEQRSNDPNVIAYEKIVDKILLK
What is the function of this protein?
Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene beta-barbatene as a major product as well as (E)-beta-farnesene as a minor product (PubMed:27790999, PubMed:31621716).  Is also able to convert geranyl diphosphate (GPP) into a mixture of monoterpenes including (Z)-beta-ocimene, linalool, beta-myrcene, limonene and alpha-terpineol (PubMed:27790999).
What are the official names of this protein?
Terpene synthase 9.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: YR040_MIMIV
Sequence: MENNNFRDSVLAILVCQFIGPNVFIIIGSIGSVIGVKIMEMYPHYCENHGIYIDKTSVGIAHGIYGIILGFIGIYVFLFVLLFILSIIFSIIYVISKRLSS
What are the official names of this protein?
Uncharacterized protein R40.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATG33_GIBZE
Sequence: MTATGTSVSLLKFVGTVSLGLLTGVSYSISSLALPALLRLPSSASASHGLSTLSAALKTPVLALTSLASAPFLISFFLAPRSSRHPYLLYTAILATLSSVAPILIPTPTPAPRRTASSAPRKSSRAKMEASYEVLGDAHSEPASDEDIEDINGEEVRAEVEGLTRSYLARTAISALGFAMAVVGIWGDGAPQSVVYVS
What is the function of this protein?
Involved in the selective degradation of mitochondria via autophagy during starvation and at post-log phase (By similarity).  Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236).  Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
What are the official names of this protein?
Autophagy-related protein 33.
What is the protein family that this protein belongs to?
Belongs to the ATG33 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: HIS7_BRASB
Sequence: MRSATIKRKTKETDIEVAVNLDGTGVVNIATGIGFFDHMLDLLARHSRIDMTVKAVGDLHIDFHHTTEDVGIALGQAVRQALGDMAGITRYASIHMPMDETLTRVVIDVSGRPMLVFRTTFPRDKIGEFDTELVREWFNAFAMNAGITLHVETLYGENAHHIAESCFKGLARALRSALAIDPRNQGEVPSTKGQLGG
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPA_ECOBW
Sequence: MPFTLGQRWISDTESELGLGTVVAVDARTVTLLFPSTGENRLYARSDSPVTRVMFNPGDTITSHDGWQMQVEEVKEENGLLTYIGTRLDTEESGVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYSSEQFRMPYSGLRGQRTSLIPHQLNIAHDVGRRHAPRVLLADEVGLGKTIEAGMILHQQLLSGAAERVLIIVPETLQHQWLVEMLRRFNLRFALFDDERYAEAQHDAYNPFDTEQLVICSLDFARRSKQRLEHLCEAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAEHVPGVLLLTATPEQLGMESHFARLRLLDPNRFHDFAQFVEEQKNYRPVADAVAMLLAGNKLSNDELNMLGEMIGEQDIEPLLQAANSDSEDAQSARQELVSMLMDRHGTSRVLFRNTRNGVKGFPKRELHTIKLPLPTQYQTAIKVSGIMGARKSAEDRARDMLYPERIYQEFEGDNATWWNFDPRVEWLMGYLTSHRSQKVLVICAKAATALQLEQVLREREGIRAAVFHEGMSIIERDRAAAWFAEEDTGAQVLLCSEIGSEGRNFQFASHMVMFDLPFNPDLLEQRIGRLDRIGQAHDIQIHVPYLEKTAQSVLVRWYHEGLDAFEHTCPTGRTIYDSVYNDLINYLASPDQTEGFDDLIKNCREQHEALKAQLEQGRDRLLEIHSNGGEKAQALAESIEEQDDDTNLIAFAMNLFDIIGINQDDRGDNMIVLTPSDHMLVPDFPGLSEDGITITFDREVALAREDAQFITWEHPLIRNGLDLILSGDTGSSTISLLKNKALPVGTLLVELIYVVEAQAPKQLQLNRFLPPTPVRMLLDKNGNNLAAQVEFETFNRQLNAVNRHTGSKLVNAVQQDVHAILQLGEAQIEKSARALIDAARNEADEKLSAELSRLEALRAVNPNIRDDELTAIESNRQQVMESLDQAGWRLDALRLIVVTHQ
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: OHR_XANCH
Sequence: MASPEKVLYTAHATATGGREGRAVSSDKALDAKLSTPRELGGAGGDGTNPEQLFAAGYAACFIGAMKAVAAQDKLKLPGEVSIDSSVGIGQIPGGFGIVVELRIAVPGMDKAELQTLVDKAHQVCPYSNATRGNIDVTLTLA
What is the function of this protein?
Organic hydroperoxide detoxification protein.  Confers increased resistance to tert-butyl hydroperoxide killing.
What are the official names of this protein?
Organic hydroperoxide resistance protein.
What is the protein family that this protein belongs to?
Belongs to the OsmC/Ohr family.
Protein: CDKL1_CAEEL
Sequence: MDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSNWILRIRQDESTPTGLTSKRSPNYLPLLNGNSNNLVSKNFSLQGGNHGNNNNNGNGINRNFLPTIS
What is the function of this protein?
Modulates cilium assembly.
What are the official names of this protein?
Cyclin-dependent kinase-like 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Localizes to the ciliary transitional zone in head and tail neurons.
Protein: RBCX_SYNY3
Sequence: MFMQTKHIAQATVKVLQSYLTYQAVLRIQSELGETNPPQAIWLNQYLASHSIQNGETFLTELLDENKELVLRILAVREDIAESVLDFLPGMTRNSLAESNIAHRRHLLERLTRTVAEVDNFPSETSNGESNNNDSPPS
What is the function of this protein?
An RbcL-specific chaperone.  The central cleft of the RbcX homodimer (RbcX2) binds the C-terminus of an RbcL monomer, stabilizing the C-terminus and probably preventing its reassociation with chaperonin GroEL-ES.  At the same time the peripheral region of RbcX2 binds a second RbcL monomer, bridging the RbcL homodimers in the correct orientation.  The RbcX2(2)-bound RbcL dimers then assemble into the RbcL8 core (RbcL8-(RbcX2)8).  RbcS binding triggers the release of RbcX2.
What are the official names of this protein?
RuBisCO chaperone RbcX.
What is the protein family that this protein belongs to?
Belongs to the RbcX family.
What are the subcellular locations of this protein?
Carboxysome. Cytoplasm. Note=Most protein is cytoplasmic, but some is in the carboxysome. This cyanobacterium makes beta-type carboxysomes (Probable).
Protein: CSX2_SCHPO
Sequence: MTGHVDPVHFERLKIQSVTFGSANDNASLQVHNVSKSPEYSKYSYSRKNNEPIEFIQLREEEGPIVKVEEEDGLTLRFQLEFHAQEGKRDVTNLTCVYGTSPQQLDRLITREFSSDANFQNNHQVFLIGNIEFHSNENSKKIEWTWSNQSLHTLYFRNGGSPIYLCFAEYDKRLNCLVPLKTFQFYVTESDQDSTPATPFPMPMHLAEETATSPEISDAPPLSGNVDPLPINSPPLTNPVARDIDQTEPEDGPLFRATILNYERTTHDMRMVLKKLIKRIEHVAHSHGLLYMSYKELMSAFERVATINPPAFKPFLDHYYAAAAQSFDSFNIDRARLLRNFLIEPLRKIYDTDIKNVSTKKKDFEETSRDYYTSLSRYLSKSEKETSSDKTKESKFAAKKRDFELSRFDYYSYMQDINGGRKGQEVLSVLTSFAANDYNLIHSSLTDIDALRPSIIQLQDIVTEANKEFQLLRAEREERRRYIETSSRELEDKDAEIAAQAYKAKVDQDTSAKQGLLLAFSKSTSDLQVVGKSGWHKYWVVLDHGKICEYANWKQSLELHTEPIDLLMATVRPAQSVSRKFCFEVITPQTKRTYQATSKAEMHSWIEAIQYSISESIVQKGKGTSMNSEETSVKHGPTSTIGKALQRVASVTSPSRHNSDSKEKKQTKSPSLVKTLKEMHSSDQSCADCNTTARVEWCAINFPVVLCIDCSGIHRSLGTHITKIRSLTLDKFNPETVDLLYATGNSFVNEIYEGGITDWKIKNFENQERRVQFVKDKYLYKRFIKSSFSHDPNTGLLESIEHSNLKEAVLCLALGADVNYQRAVVKALLKNNYLIAELLTLNGASLNVDEVTMETLSARAQAFVMNRATP
What are the official names of this protein?
Protein csx2.
Protein: Y1276_STAAB
Sequence: MKNYSFYQFVMTVRGRHDDKGRLAEEIFDDLAFPKHDDDFNILSDYIETHGDFTLPMSVFDDLYEEYTEWLKF
What are the official names of this protein?
UPF0346 protein SAB1276c.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: RIC4_ARATH
Sequence: MRDRMERLVVLPFSIGCISVSSVAVLSPLSKPHHHHSRQVIREQEEEDNMKNVFKFLAVSKPEISIGINRIFKSFKTISQLFADKDEEKEEVETSGMEIGVPTNVKHVSHIGWESGLTAATGPGKGWEDLIPPELLAAAASKKEINPHLHPTL
What is the function of this protein?
Functions as downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family.  Participates in the propagation of ROP GTPase signals in specific cellular responses.  Required for actin cortical microfilament assembly.  Activated by ARAC4/ROP2 to promote the assembly of cortical actin microfilaments required for lobe formation and lateral expansion of pavement cells.  Interaction with, and activation by ARAC4/ROP2 is inhibited by RIC1.  Functions as downstream effector of ARAC11/ROP1 to promote the assembly of apical F-actin associated with vesicle accumulation in the tip of the growing pollen tube.  Counteracts the ARAC11/ROP1-RIC3 pathway, which activates calcium signaling that leads to apical F-actin disassembly associated with exocytosis, to control actin dynamics and pollen tube apical growth.  Downstream of ARAC11/ROP1, is involved in the growth responses to the root-colonizing endophytic fungus P. indica.
What are the official names of this protein?
CRIB domain-containing protein RIC4, ROP-interactive CRIB motif-containing protein 4, Target of ROP protein RIC4.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SPAST_DROAN
Sequence: MVRTKNQSSSSSASSSTKSPIKSGSAGSGSAAGGNSASGSRQSTHRSSSASNVASAAAAAVASSNRTRTSPGSSPDGDDDTTTTDDLTPTSCSPRSGHHHHGHPYGGSSVHKQNLYVVSFPIIFLFNVLRSLIYQLFCIFRYLYGASTKVIYRPHRRDCNIEIVVQNSKDQQQQHQSQPLSYPLELSEGGNPEQQLPSQTQRYRAIQPLEMASNRPGGGYSPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKELAIELYRKGIKELEDGIAVDCWSGRGDVWDRAQRLHDKMQTNLSMARDRLHFLALREEDLRMQRLSLKEKQQKTLPQSDYKALKSREPMLAGMTNDPLKPRVRSSGYGPKASTSAQAAAATAASGRKLTIGTKRPGNLAVANKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPLRSRTPINNNGPSTSGSGASTPVVSVKGVEPKLVQLILDEIVEGGAKVEWSDIAGQEVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERSSNEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQTRELLLSRLLQKQGSPLDTEALRRLAKTTDGYSGSDLTALAKDAALEPIRELNVEQVKCLDISAMRAITESDFHSSLKRIRRSVAPQSLNSYEKWSQDYGDITI
What is the function of this protein?
ATP-dependent microtubule severing protein.  Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle.  Regulates microtubule stability in the neuromuscular junction synapse.  Involved in lipid metabolism by regulating the size and distribution of lipid droplets.  Involved in axon regeneration by regulating microtubule severing.
What are the official names of this protein?
Spastin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Spastin subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Chromosome. Lipid droplet. Note=Forms an intramembrane hairpin-like structure in the membrane. Colocalizes with cellular microtubule arrays. Localizes to chromosomes from prometaphase/metaphase to anaphase, and this requires microtubules. Localizes to discrete punctate cytoplasmic foci which may correspond to secretory vesicles.
Protein: ARGE_ECOSE
Sequence: MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRNKFNMLASCGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLKKPLYILATADEETSMAGARYFAETTALRPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYEAFTVPYPTLNLGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVSERWPGRLTVDELHPPIPGYECPPNHQLVEVVEKLLGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGK_HUMAN
Sequence: MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ
What is the function of this protein?
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762).  Does not phosphorylate sphingosine (PubMed:15939762).  Phosphorylates ceramide (By similarity).  Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity).  Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726).  The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726).  In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724).  Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762).
What are the official names of this protein?
Acylglycerol kinase, mitochondrial, hAGK, Multiple substrate lipid kinase, HsMuLK, MuLK, Multi-substrate lipid kinase.
What is the protein family that this protein belongs to?
Belongs to the AGK family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane (PubMed:28712724). It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it (PubMed:28712724, PubMed:28712726).
Protein: RL2_BURO0
Sequence: MAIVKVKPTSPGRRAMVKVVNKNLHQGKPFAALLDSQSSTAGRNNNGRITTRHKGGGHKQHYRIVDFRRTKDGIPAKVERLEYDPNRSANIALVLYADGERRYIIAPKGLTVGQQLMSGSEAPIRAGNTLPIRNIPVGTTIHCIEMLPGKGAQMARSAGTSAMLLAREGVYAQVRLRSGEIRRVHIECRATIGEVGNEEHSLRQIGKAGANRWRGIRPTVRGVAMNPVDHPHGGGEGKTAAGRDPVSPWGTPAKGYRTRSNKRTTTMIVQRRHKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: TU55_LOPAL
Sequence: EACDDSHPCNKTLACSGNKCLIPYGSTVWDCESGFDCVIGVVCTYHGGDKVGRCTQDHRCQRGACTNPATECDEDEVCGYKEGETCYGPCRKGLTCRLGRCRP
What is the function of this protein?
Acts as a neurotoxin by inhibiting an ion channel.
What are the official names of this protein?
Turripeptide OL55-like.
What are the subcellular locations of this protein?
Secreted.
Protein: RS2_CAUVC
Sequence: MALPEFSMRQLLEAGAHFGHQTHRWNPKMDRYIFGSRSNIHIIDLSQSIPLLHQALVKVREVAAAGGRVLFVGTKRQASDPVATAAKRCAQYYVNHRWLGGTLTNWRTVSGSIARLRELEGVLAGEGQGRSKKELLQLTRERDKLELSLGGIKDMGGIPDIMFVIDTNKEAIAILEARKLNIPVVAILDTNCDPDGITYPIPGNDDAARALQLYCDLIADAVLDGLAAGQAAAGVDLGASVAPVEPALARELAPEAPAAEAAPESAEG
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: HIS1_SACD2
Sequence: MSQLTIALTKGRILLETLPLLEAAGIAPLEDISKSRKLTFETTSPDVRLLILRGSDVPTYVEFGAADVGVSGKDTILEHGSTGFYEPLDLRIAKCRLMTAGIAGETLKPGRIRVATKYTNLAKQYYAEQGRQVDLIKLYGAMELAPILSLADEIVDIVDTGNTLKANGLEARDHIADISSRLIVNKASMKMKHQQIEALIDAISSAVNERAAA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_COXB1
Sequence: MVSRVAKNPIKIPTGVEVNVAGQQITVKGKLGTLTRVIHRAVKVTKTDAELQTICANDSPGSNALAGTARAVLANMVQGVHTGFQRKLVMVGVGYRAKAEGKKLNLTVGLSHPVNIEMPEGITVETPSQTEIIVKGADKQRVSQVAANIREIRPPEPYKGKGIRYDNERVILKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.