PharMolix/UniProtQA huggingface dataset:
Protein: ENO_COREF
Sequence: MAEIMHVFAREIMDSRGNPTVEAEVFLDDGSHGVAGVPSGASTGVHEAHELRDGGDRYLGKGVLKAVENVNEEIGDELAGLEADDQRLIDAAMIKLDGTENKSRLGANAILGVSMAVAKAAADSAGLPLFRYIGGPNAHVLPVPMMNIINGGAHADSGVDVQEFMIAPIGFDSFSEALRAGAEVYHALKKVINEKGLSTGLGDEGGFAPSVESTRAALDLIVEAIKKAGFEPGKDIALALDVASSEFFKDGKYHFEGGEHTAEEMANVYAELVDEYPIVSIEDPLQEDDWDGYVALTAQIGDKVQIVGDDFFVTNPARLKEGIAKKAANSILVKVNQIGTLTETFDAVDMAHRAGYTSMMSHRSGETEDTTIADLAVALNCGQIKTGAPARSDRVAKYNQLLRIEQLLGDAAVYAGRSAFPRFQG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: SYS_CHLPN
Sequence: MLDIKIIRKTPEECETRLRKKDPKISLEPVLSLDKEVRQLKTDSETLQAQRRLLSQDIHKAKTQGVDATNLIQEVETLAADLEKIEQHLDQKNAQLHELLSHLPNYPADDIPVSEDKAGNQVIKSVGDLPIFSFPPKHHLELNQELDILDFQAAAKTTGSGWPAYKNRGVLLEWALLTYMLQKQAAHGFQLWLPPLLVKKEILFGSGQIPKFDGQYYRVEDGEQYLYLIPTAEVVLNGFRSQDILTEKELPLYYAACTPCFRREAGAAGAQERGLVRVHQFHKVEMFAFTTPNQDDIAYEKMLSIVEEMLTELKLPYRLSLLSTGDMSFTASKTIDAEVWLPGQKAFYEVSSISQCTDFQSRRSGTRYKDSQGKLQFVHTLNGSGLATPRLLVAILENNQQADGSVVIPEVLRPYLGGLEILLPKDQ
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METN_STRPB
Sequence: MNEAIIQLDHIDITFRQKKRVIEAVKDVTVHINQGDIYGIVGYSGAGKSTLVRVINLLQAPTNGKITVDGDVTFDQGKVQLSANALRQKRRDIGMIFQHFNLMAQKTAKENVAFALRHSSLSKTEKEHKVIELLELVGLSERADNYPAQLSGGQKQRVAIARALANDPKILISDEATSALDPKTTKQILALLQELNRKLGLTIVMITHEMQIVKDICNRVAVMQNGVLIEEGSVLDIFSNPKEALTQEFITTATGIDEALEKINQQDIVKHLPANALLAQLKYAGTSTDEPLLNSIYRQFEVTANILYGNIEILDHIPVGDMIVVLEGQAENILAAEKALHEAGVDVSILKRGA
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ZFP69_BOVIN
Sequence: MLQQLLITLPTEASTWVKLHHPENAKEGAPLWEDVTKMFEGGALLSQDADETQGESLKDELTPGTPTTDSQELLTFKDISVDFTQEEWGQLAPAHRNLYREVMLENYGNLVSVAGCQLSKPSVISQLEKGEEPWMTEKEGPGDPNSDLKSKTETSASNAKYNILQEQLYHGMMMERFMRDDVIYSTLKKVSEYDDELEKHQDRHGRNVRQTIMTHKKRSQETYKFGKNIVSSNVVIEQRLRKCDTPRKRNKCKSDVINHPTSYIRVKTYECNICEKAFKQPIHLTEHMRIHTGEKPFRCKECGRAFSQSASLTTHQRIHTGEKPFECEECGKAFRHRSSLNQHHRTHTGEKPYICDKCQKAFSQNISLIQHLRTHSGEKPFTCNECGKTFRQIRHLSEHIRIHTGEKPYACTACCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHKTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECNECGKAFSYNSSLTRHHEIHRRNVFQNNI
What is the function of this protein?
Putative transcription factor that appears to regulate lipid metabolism.
What are the official names of this protein?
Zinc finger protein 69 homolog, Zinc finger protein 642.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRC_PSE14
Sequence: MSDRLTLLRPDDWHIHLRDGAVLPHTVADVARTFGRAIIMPNLVPPVRNAQQADAYRQRILAARPAGSRFEPLMVLYLTDQTTPEDIRTAKASGFVHAAKLYPAGATTNSDSGVTSIDKIFPALEAMAEVGMLLLVHGEVTRGEIDVFDREKVFIDEHLRRVVERFPTLKVVFEHITTGEAVQFVNEASANVAATITAHHLLYNRNHMLVGGIRPHFYCLPILKRNTHQASLLDAATSGSGKFFLGTDSAPHAQHAKENACGCAGCYTAYAAIELYAEAFEQRNALDKLEGFASLHGPAFYGLPANQDTITLVRDEWTAPASLPFGELTVIPLRAGEKLRWRLEEHA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: PROA_ALIFM
Sequence: MNLTTMGQAAKAAAFDLAVAPTAQKNKALAIIADELEANKDAILAANEKDIKAAVEAGISEAMQDRLLLTEERLVGIANDVRNVINLNDPVGSEIDSKVLENGMSLSRRRVPIGVIGVIYEARPNVTIDIASLCLKTGNASILRGGKETFFSNMELVKVIQVALEKAGLPAASVQYIEKPDRELVSQLLTMDDYVDMIIPRGGAGLHKMCKENSSIPVIIGGFGISHAFVDESADLERALVVVDNSKAQRPSACNALDTLLVHEAVAPQFLALLVNNMAGRVELVAEPKAYGLLKEFEGVSLREAQEGDFDTEWLSYTLGVKVVADVNEAAAHMQKHNASHSDTILTNNIESAEKFINTAGSAAVYVNASTRFTDGAQFGLGAEVAVSTQKLHARGPMGLEELTSYKWVGKADYLIRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_COXB2
Sequence: MADMSVKQLADLVRTTPERLLEQLKEAGVAITHVDQTISDEEKRKLLLHLKTSHSTETDKKRSKIVLKRKKLSVVKSGKKSVNVEIRSKRTYTKPVVEQKRETEPAPTQEVPLTSDTTNLNEKAEVNVATLEKAVEAEVKEEAKKTPSEKKETPKKGPRKETRRSRKPDKEDKWEREELHMTKLVEERRRRHKPAHVPDSDSASAKLEQGFARPTAPVVREVALPESITVADLAQKMSVKAAEVIKAMMKLGAMVTINQRIDQETAAIVVEEMGHKPKLIKEDVLEENLVATLGEQIGEAVPRAPVVTIMGHVDHGKTSLLDYIRRTKVTSTEAGGITQHIGAYHVETELGMITFLDTPGHEAFTAMRARGAKCTDIVVLVVAADDGVMPQTVEAIQHARAAKVPVVVAVNKIDKPEADPERIKTELSTHDVLPEEWGGDTMFQPISAKTGEGIDALLERILLQAEVLELKAVDNGPARGMVVESRLDRGRGPVATVLVTSGELHLGDILLVGREYGRVRAMIGDDGRPCESAGPSMPVEVLGLSGTPVAGEEAIVVPDERKAREIARFRQGKYREVRLAKKQTAHLERIFDRMGEGKQNTLNIVLKADVQGSLEALTEALNKLSTDEVKVNIIASGVGGITESDVNLAIASDAVVIGFNVRADAPTRVLVEREGVDLRYYSIIYDLIDEVKKALSGLLAPEFEEKIVGLAEVRDVFRSSKIGAIAGCMVVEGVVRRHLPIRVLRDNVVIYEGQLESLRRYKEDVAEVRQGTECGIGVKNYNDVKVGDQIEVYEKTQVHRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEP2B_XENTR
Sequence: MSKQQAQFTNPETPGYVGFANLPNQVHRKSVRKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVVPGAADKIERTVEIEASTVEIEERGVKLRLTVVDTPGYGDAMNCVDCFKPIISYVDNQFERYLHDESGLNRRHIVDNRVHCCFYFISPFGHGLKPLDVEFMKALHNKVNIVPVIAKADTLTLRERERLKRRVLDEIEEHGIKIYQLPDAESDEDEDFKEQTRLLKASIPFTVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKKGVASKVENVEVTKDQILQEKEAELRRMQEMIARMQAQMQIQSQSGDAQHL
What is the function of this protein?
Filament-forming cytoskeletal GTPase.  Required for normal organization of the actin cytoskeleton.  Plays a role in the biogenesis of polarized columnar-shaped epithelium.  Required for the progression through mitosis through regulation of chromosome congression.  During anaphase, may be required for chromosome segregation and spindle elongation.  Plays a role in ciliogenesis and collective cell movements including convergent extension during gastrulation.  In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Controls cell shape and not polarization of cells during convergent extension (By similarity).
What are the official names of this protein?
Septin-2B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane. Note=Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes.
Protein: SOTI_DROER
Sequence: MDTLHEHEAGNLYEEQRVDRVGDALTADAGDDADTLEDGQQQQQQQHQQLLGVNRQMAILLDAPQEPPMAVFPARGGLNGPPRLRKKRSFYTMVKPSPPCESQEPEMCLLLASVTRAMRQVREDQRGEYFANYLVENMTSQNYPNGVGLPQHWGEF
What is the function of this protein?
Post-meiotically transcribed gene that has a role in late spermiogenesis; required for actin cone progression during spermatid individualization.
What are the official names of this protein?
Male-specific protein scotti.
What is the protein family that this protein belongs to?
Belongs to the male-specific scotti family.
Protein: TIP_SHV48
Sequence: MANEGEEIELTEFPETEKERKDEEKLSSCSEETTDTSSSSSSDHVPAPIEVNVIIQNSSRTEDELQNSTKFAVANEGKEIELTGFQGKLSSCSEETTATSSSYSSKQASVCIEENGDNETSTYRPQNVLTNLNSLYTTFEDARAQGKGMVRYKSEDLQSFLEKYPPDYRKPKRDLSATWDPGMPTPALPPRPANLGERQASTVRLHVKESNCKQPRERKANERNIVKDLKRLENKVNAIICLVVVILAVLLLVTVLSILHIGMKS
What is the function of this protein?
Plays a critical role in virus induced T-cell transformation.  Binds to T-cell-specific tyrosine kinase LCK SH2 and SH3 domains, thereby activating its kinase activity.  Once phosphorylated by host LCK, forms a complex with at least STAT 1 and 3, resulting on the phosphorylation of STAT3 and presumably STAT1, and their migration into the nucleus to induce transcription of target genes.  Stimulates host ILF3/NF-AT-90 activity.  Association with host NXF1/TAP transduces the signal up-regulating surface expression of adhesion molecules as well as activating NF-kappa-B activity.  Acts synergistically with StpC to stimulate NF-kappa-B activity and interleukin-2 gene expression.  Activation of NF-kappa-B protects lymphocytes from apoptosis, thereby facilitating viral induced cell transformation.  May cause down-regulation of host LCK and cell apoptosis when stably overexpressed ex vivo.  Interaction with WDR48 induce degradation of T-cell receptor in a lysosome-dependent fashion, when both proteins are overexpressed.  The biological effect of this interaction remains controversial since no T-cell receptor degradation is observed in infected cells (By similarity).
What are the official names of this protein?
Tyrosine protein kinase-interacting protein, Tip, TipC484.
What are the subcellular locations of this protein?
Host cell membrane; Single-pass membrane protein.
Protein: TACY_LISMC
Sequence: MKKIMLVFITLILVSLPIAQQTEAKDASAFHKENLISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEINYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNSVDNPIE
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Acts as major virulence factor required for the escape of bacteria from phagosomal vacuoles and entry into the host cytosol.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Listeriolysin O, LLO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein that then inserts into the host membrane and forms pores formed by transmembrane beta-strands.
Protein: UREG_CORGB
Sequence: MGPIRIGVGGPVGAGKTQLVERITRALIDEVSMAAITNDIYTIEDAKILAANGVLPEERIVGIETGGCPHTAIREDTSMNDAAIKDLVERFPDLELIFVESGGDNLSATFSPELVDFSIYIIDVAQGEKIPRKAGQGMIKSDLFIINKTDLAPYVGANLDVMVEDAKTFRKNKPFCLTNLRTDDGLDKVLEWIRHEVMMQDLQEA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFH_YERPY
Sequence: MPDIRVEVVYALSERQYLRTVSLVVGSTVEDAIKASGLLELRPDIDLEKNKVGIYSRPVKLGDKLNDGDRVEIYRPLIADPKELRRQRAEQAKK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: Y5878_PSEA8
Sequence: MLSWAITFLIIAIIAAVLGFGGIAGAATGIAKILFVLFLVLFVVSFFFGRRRG
What are the official names of this protein?
UPF0391 membrane protein PLES_58781.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOB_ORITB
Sequence: MQYLLSKKRIRKNFGKINLVSSIPNLIEVQKNSYNKEFLQLGVPVDCRENKGLQGVLNSIFPIHDLDGSAILEFVRYDFDEPKYDVEECIQRGLSYTAALKITLSLIVLDDSDKSDPKEIKGIKEQAVYFGDIPLMTANGTFVINGTERVVVSQMHRSPGVFFDHDDGKTHSTGKLIYSARVIPYRGSWLDFEFDAKDLLYFRIDRKRKLYVTTLLMALGMSSHDILNFYYESATYKKYKKSENGWIVDFLPELVSTKHLAYDLIDAQTGKVLLNAGQKITFRIAKMLADKGVKQILVKNDSLVGKLLAEDLVNNQTGEVLLGVGEEITNDILTIVNDLQITTVKVLAVGGQCGPYVRNTLFLDKNKDQKSSLVEIFRVLKPGEMATTAASRGLLDSLLFDNNRYDLSEVGRIKINSRLNLDIDLKNTCITVEDIKKIIKLLVDIKDGKALVDDIDHLGNRRVRSVGELVENQFRTGLVRIAKFIVERIGSVEIDAVVPNDLVNAKLLTSVIKEFFGTSQLSQFMDQTNALSQITHIRRLSALGPGGLNRDRAALEVRDVHPTHYGRICPIETPEGQNIGLINSLAIFAKINRYGFIESPYRRVINRRVTDEVVYLSALEEGRYKIAQADTSLCTNDCLIDGLVSCRYDGNFVMVLAQEVDFIDLTPMQVVSVAASMIPFLENDDANRALMGANMQRQAVPLLKSQAPLVGTGIESVVAHDSGTVVAALHDGIVEQVDSTRIVVKTSVKKDAGAPGVDIYNLKKFQRSNYNTCINQKVLVNVGDIVKKGDVIADGVATNKGEIALGRNVLVAFIAWNGYTFEDSILVSERIVKEDIYTSIHIEELELVARDTRLGPEEITRDIPNVNDESLRHLDEVGIVNIGAKVRTGDILVGKVTPKSESPVTPEEKLLRAIFGEKASEVKDSSLYVPPGITGTVIDVRVFSRRGIDKDERTLAIEKQKIRKLVKDYEDELAVIQHFTIVRVKELLVGQVAACSLDSIIIGDKLDEAMLNKLTNEQLLKLKADNSSIMDEISEIKCHYETTRAQLTSQLNSKIEKIQCGDDLPQGALRVVKVFIAIKHRLQPGDKMAGRHGNKGVVSKVVPEEDMPFLEDGTVVDIVLNPLGLPARMNVGQILETHLGWAGVNLGRKIGKMVDDYYSGNNQCTDEIRKFVKKIYANNSIADTIDQVNDQQLIEICQELRQGIYFSTPVFDGAKIADIKQMLELADVDKSGQVRLIDGRTGEYFDRRCTVGYQYLLKLHHLVDEKIHARSIGPYSLVTQQPLGGKSHFGGQRFGEMECWALEAYGAAYTLQELLTTKSDSVEGRIKMYQAIIRGNNNFVSGVPESLNVMIKELRSLCLNIQLEENDEEDENEDENY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RECF_YERPY
Sequence: MALTRLLIKDFRNIESADLALAAGFNFLVGPNGSGKTSVLEAVYTLGHGRAFRSLQAGRVIRHECAEFVLHGRVDANEREASVGLSKSRQGDTKVRIDGTDGHKVAELAQMLPMQLITPEGFTLLNGGPKFRRAFLDWGCFHNEPGFFTAWSNLKRLLKQRNAALRQVSRYTQIRAWDQEIIPLAERISEWRAAYSDAIAADISATCALFLPEFALSFSFQRGWDKESDYGELLARQFERDRALTYTAVGPHKADFRIRADGTPVEDLLSRGQLKLLMCALRLAQGEFLTRQSGRRCLYLLDDFASELDTGRRRLLAERLKATQAQVFVSAVSAEQVADMVGEKGKMFRVEHGKIEVQPQD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXC_PARPJ
Sequence: MLKQRTIKQIVKTVGIGLHSGRKVELTLRPAAPDTGIVFSRVDLATPVDIPASAMAIGDTRMASVLQKDGARVSTIEHLMSACAGLGIDNLYIDVTAEEIPIMDGSAGSFVFLIQSAGIEEQNAAKKFIKVTKPVEIRDGDKFARLDPYFGFKLKFTIDFRHPAVDKTGQALEVDFANTSYVREIARARTFGFAHEVEMMRELGLARGGSMDNAIVLDEYRILNNDGLRYDDEFVKHKMLDAIGDLYVIGHPLLAAYDAYKSGHGLNNALLRELLAHEDSYEIVTFDDTQKAPRGFAYETQTAFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: GTFA_STRPN
Sequence: MTIYNINLGIGWASSGVEYAQAYRAGVFRKLNLSSKFIFTDMILADNIQHLTANIGFDDNQVIWLYNHFTDIKIAPTSVTVDDVLAYFGGEESHREKNGKVLRVFFFDQDKFVTCYLVDENKDLVQHAEYVFKGNLIRKDYFSYTRYCSEYFAPKDNVAVLYQRTFYNEDGTPVYDILMNQGKEEVYHFKDKIFYGKQAFVRAFMKSLNLNKSDLVILDRETGIGQVVFEEAQTAHLAVVVHAEHYSENATNEDYILWNNYYDYQFTNADKVDFFIVSTDRQNEVLQEQFAKYTQHQPKIVTIPVGSIDSLTDSSQGRKPFSLITASRLAKEKHIDWLVKAVIEAHKELPELTFDIYGSGGEDSLLREIIANHQAEDYIQLKGHAELSQIYSQYEVYLTASTSEGFGLTLMEAIGSGLPLIGFDVPYGNQTFIEDGQNGYLIPSSSDHVEDQIKQAYAAKICQLYQENRLEAMRAYSYQIAEGFLTKEILEKWKKTVEEVLHD
What is the function of this protein?
Required for the polymorphic O-glycosylation of serine-rich repeat protein PsrP.  Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in PsrP (PubMed:24936067, PubMed:28246170).  Part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins encoded upstream in the same operon (Probable).  The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to PsrP (experimentally characterized with truncated PsrP-SSR1 constructs); this subunit alone has weak N-acetylglucosaminyl transferase activity that is 10-fold stimulated by GtfB.  The complex requires at least a 25 residue-long peptide for activity; the in vitro assay has only been seen to glycosylate Ser residues (PubMed:24936067).  The alpha linkage was shown in L. reuteri.
What are the official names of this protein?
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase GtfA subunit, Glycosyltransferase GtfA, O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Cell membrane association requires GtfB.
Protein: Y1480_METJA
Sequence: MFMREIELRGHIIDSLILPKVFDKILDMGGDYKVLEFEIGKRKTDPSYAKILVIGRDERHVDEILNELRDLGAEIPEIEEVELQPAEKDMVLPEGFYSTTNHKTFIRFKGKWIEVENQKMDGAIVVYPDEMRAEVKTIRNIKKGDLVVVGHKGVRVIPPEKPREGGGLFEFMKSDASSEKPKETIIRRIAKEMYEIREKYRKTGKGGIVVVGGPAIIHTGAGWALAKLIRMGYVQALFAGNALATHDIESVLYGTSLGVDLKTGKSVPGGHSHHLRAINTIMRAGSIKDAVEQGILKEGVMYECIKNNIPYVLAGSIRDDGPLPDVITDVVKAQEKMRELLKGKDMVLMLSTMLHSIATGNLLPSWVKTICVDINPAVVTKLMDRGTSQALGIVTDVGVFLPMLVEELEKLEKEKEKSEKREE
What are the official names of this protein?
Uncharacterized protein MJ1480.
Protein: HBA_MUSLU
Sequence: VLSPADKTNVKSTWDKIGGHAGEYGGEALERTFASFPTTKTYFPHFDLSHGSAQVKAHGKKVADALTNAVAHMDDLPGAMSALSDLHAYKLRVDPVNFKLLSHCLLVTLACHHPAEFTPAVHASLDKFFSAVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1/2, Alpha-1/2-globin, Hemoglobin alpha-1/2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PCCB_RAT
Sequence: MAAVIRIRAMAAGTRLRVLNCGLGTTIRSLCSQPVSVNERIENKRHAALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFLESDMFVEHRCADFGMAAEKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPEFVKSVTNEDVTQEQLGGAKTHTTVSGVAHRAFDNDVDALCNLREFLNFLPLSNQDPASIRECHDPSDRLVPELDTVVPLESSKAYNMLDIIHAVIDEREFFEIMPNYAKNIVIGFARMNGRTVGIVGNQPNVASGCLDINSSVKGARFVRFCDAFSIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKITVITRKAYGGAYDVMSSKHLLGDTNYAWPTAEIAVMGAKGAVEIIFKGHEDVEAAQAEYVEKFANPFPAAVRGFVDDIIQPSSTRARICCDLEVLASKKVHRPWRKHANVPL
What is the function of this protein?
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites.  Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity).  Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity).  Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity).  Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).
What are the official names of this protein?
Propionyl-CoA carboxylase beta chain, mitochondrial, PCCase subunit beta, Propanoyl-CoA:carbon dioxide ligase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RNY_ALIB4
Sequence: MEDLIVAIVVGAFSSAISIFVVRKLDRAKFEVFIEQAKAKAKVIEHEAEMALKDAQLKAKIECDREFKSAKREYEAMLLKIERKERELNEHLESELKAIKLEKEQIVEKNRKITTLKDGLEEQKKTYEEKTLEAIKILENACGLTQSEAKELMLKKVKEDSRAEISSIFRKRYKIAEQNTKNEINNMLSQAVTRYAGEFAAERLINNIPLNDEETKGKIIGKEGRNIKALEMLLGVDIIIDDTPNTITVSSFNLYRRAVATKTIRELLEDGRIQPARIEEIYKKVKSEFDKNIQKEGEDVVMELGIKTMHPELIKLVGRLRYRASYGQNALAHTLEVAHLSGLLASQMGGDAILARRAGLLHDIGKALTHEAPGSHVDLGAEICKRYDECDTVINAIYAHHGHEEPINVESAAVCAADALSAARPGARREVLESFLKRVEEVENISTSKLGVLNAYAINAGREVRVIVKAELVNDDEAVLLATEIAKEIEEKVQYPGEIKVNVIRETRAESYAR
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RNZ_MYCSS
Sequence: MIEVTLLGTGSPVPDARRAGPSTLVRAGGHAFLVDCGRGVQLRMAAAGIAANGLSALLLTHLHSDHIADLGDLLITRWVTTFTDQVPLQIIGPPGTAETVTAMLAAFGRDIGYRIAHHPDLTAPPPVEVHEVTEGVAWDHDGVTVRVAPTDHRPVAPTIGFRVEHADASVVLAGDTVPCATLDALAAGAGALVHTAIRKDLVELAPQQRVREVCEYHSSVEEAAETAERAGVGILVLTHYLPPIAPGQEADWRARAATAFPRQIELGDDLHRVEVHPGVCVKPAG
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.