PharMolix/UniProtQA huggingface dataset:
Protein: SAHH_BDEBA
Sequence: MKKNAKMKAPTATKTAAKTPVVDYRVSKEAMENPEVFAKLAKWGREEIKIAETEMPGLMALRKEYKKQQPLKGARIAGCLHMTIQTAVLIETLVELGAEIRWSSCNIFSTQDHAAAAIAAAGIPVFAWKGLTEQEFNWCIEQTIVGWGKEGFNMILDDGGDLTNMMHEPRFAKEMKKIIGISEETTTGVHNLEVLVKQGKLKVPAININDSVTKSKFDNLYGCRESLADGIKRATDVMVAGKICVVAGYGDVGKGSAHSLRGLGARVLVTEIDPICALQAAMEGFEVTTMEDAAPLGDIFVTATGCCDIITDKHFMKMKNNAIVCNIGHFDIEIDMAWLNKNSKMREVKPQVDIHTLKNGKQVIILAKGRLVNLGCATGHPSFVMSNSFTNQVLAQMELFNNRDKYQDIAVYRLPKHLDEKVAALHLDKLGVKLTKLSSKQAKYLHMSPQGPFKPEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAP_VZVO
Sequence: MDLRSRTDDALDMELHAGFDAPEIARAVLTEKTLTGLISSISPLVNRLRDSILIFSDEGLIIHCSLETEQLYIPIPANMFDQYNWTGPRMVVLAATEGRSSLIDAFRHTKDPSTPTRLYFKFTGQPPERSIIQTMVWQRPGDCGPDDQVQCYKQVVKRELACYTMMFPNLTPDISICLKRDQFTRLQRLLKTFGFTTCFILTATDMYIQTAGGGFISFNVSLDINGSKPTPYNLIRSITNSKRILNNVVYGSGSMREFGVLLETHSGFRSAVQNLKLTRDETCYINFYLALTNSPMVGLYIQRSAPVHSFFYATFLSPKDLKEKLTSMQLFANTESVKDEPPLKKRRNLLTKRNEKNTGNKMGGKLPETTWQEGIGIREYCVAPPVDPAGTLDYSELSRESDVICTVK
What is the function of this protein?
Plays an essential role in viral DNA replication by acting as the polymerase accessory subunit.  Associates with the viral polymerase to increase its processivity and forms high-affinity direct interactions with DNA.  Facilitates the origin-binding protein loading onto DNA thus increasing its ability to assemble into a functional complex capable of unwinding duplex DNA (By similarity).
What are the official names of this protein?
DNA polymerase processivity factor, DNA-binding gene 16 protein, Polymerase accessory protein, PAP.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA polymerase processivity factor family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: IPNS_STRCT
Sequence: MPVLMPSADVPTIDISPQLFGTDPTPRRTSRGRSTRPARGSGFFYASHHGIDVRRLQTWSNESTTMTDQRSTTWRSTRYNENNSHVRNGYYMARPGRETVESWCYLNPSFGEDHPMMKAGTPMHEVNVWPDEERHPDFGSFGEQYHREVSASRRCCCGASRWRRQAGESSSNEVTEEDTLSAVSMIRYPYLDPYPEAAIKTGPDGTRLSFEDHLDVSMITVLSKTEVQNLQVETVDGWQSLPTSGENFLINCGTYLGYLTNDYFPAPNHRVKYVNAERLSLPFFLHAGQNSVMKPFTRRTGDRKLNPAVTYGEYLQEGFTR
What is the function of this protein?
Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin.
What are the official names of this protein?
Isopenicillin N synthase, IPNS.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: CERK_ARATH
Sequence: MEEGRDDEYCSFSNSGDRDGGLSGCFFLDHVGQVLLSRNHDGLSWKCLDSSDCEGTTCLGIIICENSETEIKFSDIYAVEFVSYGLVHSPKLGLRHAKECFRERLLNTQEMYRFTVHGFQSSPKEPCLWNLAAFTFGHMDLQTCQSWMDQLNYSLIKEVERPRNLLVFVHPKSGKGNGSKVWETVSKIFIRAKVNTKVIVTERAGHAFDVMASIQNKELHTYDGIIAVGGDGFFNEILNGYLLSRLKVPLPPSPSDSFNSVQSRGSSSVPEPGDEVHETDQKEHYPLLPDSVQEVMNFRTVNGSCEGIEDPDHPFSSERPRFGLIPAGSTDAIVMCTTGARDPVTSALHIILGRKLFLDAMQVVRWKTASTSTIEPYIRYAASFAGYGFYGDVISESEKYRWMGPKRYDYVGTKIFLKHRSYEAEVMFEEAESENSKASLHTRSKTWPFRNTTRSEKILCRANCKICNSKVGWNSASTTLNPCPEKTRWCRTKGRFLSIGAAVMSNRNERAPDGLVVDAHLSDGFLHLILIKDCSRPKYLWHLTELAKRGGEPLNFEFVEYHKTRAFTFTSFGEESVWNLDGEIFEAHQLSAQVLRGLIPLFASGPEI
What is the function of this protein?
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate.  Possesses high activity on ceramide analogs (C6, C8 synthetic ceramides) and lower activity on C6 and C8 dihydroceramides.  Has weak activity on natural ceramides (a mixture of ceramides from bovine brain) and the synthetic substrate C2 ceramide.  Has very poor activity on diacylglycerol and sphingosine.  Ceramide is a critical sphingolipid metabolite that induces programmed cell death (PCD) in plants and ceramide-1-phosphate has a PCD suppressive effect.  Thus, ceramide phosphorylation plays a role in the modulation of PCD and CERK activity is crucial for the maintenance of cell viability.
What are the official names of this protein?
Ceramide kinase, AtCERK, Protein ACCELERATED CELL DEATH 5.
Protein: MIF2_CAEEL
Sequence: MPMVRVATNLPNEKVPVDFEIRLTDLLARSMGKPRERIAVEIAAGARLVHGATHDPVTVISIKSIGAVSAEDNIRNTAAITEFCGKELGLPKDKVVITFHDLPPATVGFNGTTVAEANKK
What are the official names of this protein?
MIF-like protein mif-2.
What is the protein family that this protein belongs to?
Belongs to the MIF family.
Protein: PURE_VIBPA
Sequence: MKVGIIMGSKSDWPTMKLAADMLDQFGVSYETKVVSAHRTPQLLADYASSAKERGIKVIIAGAGGAAHLPGMAAAFTSLPVLGVPVQSRALKGMDSLLSIVQMPKGIAVGTLAIGEAGAANAGILAAQILGTHDESIMAKVEAFRNEQTETVLANPNPAED
What is the function of this protein?
Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
What are the official names of this protein?
N5-carboxyaminoimidazole ribonucleotide mutase, N5-CAIR mutase, 5-(carboxyamino)imidazole ribonucleotide mutase.
What is the protein family that this protein belongs to?
Belongs to the AIR carboxylase family. Class I subfamily.
Protein: CLPX_TOLAT
Sequence: MTDKRKDGDHSKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIRDIGGARPHMTELPTPHKIRAHLDDYVIGQDLAKKVLAVAVYNHYKRLRSGSSADGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTIAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVVEQRTAQGAGIGFNAEVKSKDKKVTLSESFAKVEPEDLVKYGLIPEFIGRLPVVATLTELDENALIQILVEPKNALTKQYQALFKLEGAELEFREDALRAIAHKAMERKTGARGLRSIVEGVLLDTMYDLPSVENVSKVVVDEHVINGETQPIMIYDNPEKQAASAD
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: PIWL3_HUMAN
Sequence: MPGRARTRARGRARRRESYQQEAPGGPRAPGSATTQEPPQLQSTPRPLQEEVPVVRPLQPRAARGGAGGGAQSQGVKEPGPEAGLHTAPLQERRIGGVFQDLVVNTRQDMKHVKDSKTGSEGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNSLLLSRPLKERRVEWLSTTKDKNIVKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYRHGTSLEIWLGYVTSVLQYENSITLCADVSHKLLRIETAYDFIKRTSAQAQTGNIREEVTNKLIGSIVLTKYNNKTYRVDDIDWKQNPEDTFNKSDGSKITYIDYYRQQHKEIVTVKKQPLLVSQGRWKKGLTGTQREPILLIPQLCHMTGLTDEICKDYSIVKELAKHTRLSPRRRHHTLKEFINTLQDNKKVRELLQLWDLKFDTNFLSVPGRVLKNANIVQGRRMVKANSQGDWSREIRELPLLNAMPLHSWLILYSRSSHREAMSLKGHLQSVTAPMGITMKPAEMIEVDGDANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRRYDSIKRYLCTKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGALWKVETDVQRTMFVGIDCFHDIVNRQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDVWCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFTLAFIVVKKRINTRFFLKHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSPDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL
What is the function of this protein?
May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.  Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements.  Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).
What are the official names of this protein?
Piwi-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Piwi subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein: BACS2_NATPH
Sequence: MVGLTTLFWLGAIGMLVGTLAFAWAGRDAGSGERRYYVTLVGISGIAAVAYVVMALGVGWVPVAERTVFAPRYIDWILTTPLIVYFLGLLAGLDSREFGIVITLNTVVMLAGFAGAMVPGIERYALFGMGAVAFLGLVYYLVGPMTESASQRSSGIKSLYVRLRNLTVILWAIYPFIWLLGPPGVALLTPTVDVALIVYLDLVTKVGFGFIALDAAATLRAEHGESLAGVDTDAPAVAD
What is the function of this protein?
Photophobic photoreceptor responsible for the negative phototaxis.  Activates the sensory rhodopsin II transducer (HTR-II) in response to blue light.
What are the official names of this protein?
Sensory rhodopsin-2, Sensory rhodopsin II, SR-II.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YB298_YEAST
Sequence: MELFIPCPERLKKMMLKEELRKELLILRCLYHPTIQIMLPTLGTLGTEKRKEKYALSLFEPILNCVGSAKTSG
What are the official names of this protein?
Uncharacterized protein YBR298C-A.
Protein: RLME_RICBR
Sequence: MTNNLSGYRNKFVRVKTSKKRTVSSSNWLRRQLNDPYVAKARIEGFRSRAAYKLLEIHEKFKIFTPNMKVVDLGAAPGGWSQVASKLIKATDGNLKNKIISVDLLEIEPIPGVESFQKDFFEKDTEELIIQALKGKADIVLSDMASNTIGHKATDHIRTLLLCEQAFEFALKVLNPSGHFIAKIFRGGAENELLNKVKREFSTVKHFKPSSSRKESTEIYLVALNRK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARP1_METMF
Sequence: MAQSLTPSVETDSKTGPSKAISFQDYLDLSALDWARLRAVLAPTLYVDYTKIGKEKWDAMSADDFMAMVSNDDFLGDLCVKTQHLIGATYWERVSESKVIGHHQLRAAHQVYTSPDLKTVKLRGHSHATNEHYYVKSGGVWKFAGLKPEVRWNEYKFEEVFKGSYTQSEKQSLP
What is the function of this protein?
Scytalone dehydratase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster (PubMed:29958281).  The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified (PubMed:29958281).
What are the official names of this protein?
Scytalone dehydratase-like protein Arp1.
What is the protein family that this protein belongs to?
Belongs to the scytalone dehydratase family.
Protein: COAA_YERPY
Sequence: MTKREQSLATPYLQFDRTQWAALRDSVPLTLTEEEIVKLKGINEDLSLDEVAQIYLPLSRLLNFYISSNLRRQAVLEQFLGTDGQRIPYVIGIAGSVAVGKSTTARLLQALLSRWPEHRSVELITTDGFLHPNKVLNERGLMKKKGFPESYDMHNLVKFVSEVKSGADYVTAPVYSHLIYDVVPDGNKVIKQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEDLLQSWYINRFLKFRQGAFSNPDSYFHNYAKLPETEAIKIATQLWNEINGLNLKQNILPTRERASLIMTKSANHAVESVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHRF1_MACFA
Sequence: MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQETPGQAEPAAAAEAQGAGNENEPREADKSHPEQRKLRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCKVTPSQEHLNGPLPEPFTNGEIQKENSREALAEAASESPRPTLVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL
What is the function of this protein?
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.  Necessary for recycling of internalized ADRB2.  Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3.  Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3.  Involved in sperm capacitation.  May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.  May enhance Wnt signaling.  May participate in HTR4 targeting to microvilli (By similarity).  Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity).
What are the official names of this protein?
Na(+)/H(+) exchange regulatory cofactor NHE-RF1, NHERF-1, Ezrin-radixin-moesin-binding phosphoprotein 50, EBP50, Regulatory cofactor of Na(+)/H(+) exchanger, Sodium-hydrogen exchanger regulatory factor 1, Solute carrier family 9 isoform A3 regulatory factor 1.
What are the subcellular locations of this protein?
Cytoplasm. Apical cell membrane. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Present in lipid rafts of T-cells. Colocalizes with CFTR at the midpiece of sperm tail (By similarity).
Protein: SYW_CAMJR
Sequence: MRVLTGLQPSGDLHIGNYFGAIKQMVDAQEKSQMFMFIANYHAMTSSQDGEKLKQNSLKAAAAFLSLGIDPQKSVFWLQSDVKEVMELYWILSQFTPMGLLERAHSYKDKVAKGLSASHGLFSYPVLMAADILLFDTRIVPVGKDQIQHVEIARDIALKVNNEWGEIFTLPEARVNEEVAVVVGTDGAKMSKSYQNTIDIFSSEKTLKKQISSIVTDSTALEDPKDHENCNIFKIAKLFLDESGQKELQIRYEKGGEGYGHFKIYLNELVNAYFKEAREKYNELLEKPSHLKEILDFGATKARKIAQEKMQKIYEKIGL
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FL1_EUCGL
Sequence: MDPEAFAVVGLRTMGGLEELFEAYGIRYLTASRIAEMGFTANTLLDMKEEELDDMMNSLSHIFRWDLLVGERYGIKAAIRAERRRLLEADDRRHHLHSTDHALLDALSHQGLSEEQVVQHSEKDQLGRAGSGDTAGTSWGAQQQRKKHRHRHHITAMKGAATEEDEEDEEEVEEMRRQREHPFIVTEPGEVARGKKNGLDYLFHLYDQCRDFLLQVQSLAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYVHCYALHCLDEHASNALRKSFKERGENVGAWRQACYHPLVTIAGRRAGWDIDAIFNAHPRLCIWYVPTKLRQLCHAHRHSSASAASSASTSTSAPTAHHLELPY
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Leafy/floricaula homolog FL1, ELF1.
What is the protein family that this protein belongs to?
Belongs to the FLO/LFY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YACL_SALEP
Sequence: MDYEFLRDVTGGVKVRMSMGHEVVGHWFNEEVKDNLSLLDEVEQAARTVKGSERSWQRAGHEYTIWMDGEEVMIRANQLDFSGDEMEEGMSYYDEESLSLCGMEDFLRVVAAYREFVSKA
What are the official names of this protein?
UPF0231 protein YacL.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: AROA_HALWD
Sequence: MDVSISRSRVRGRVRAPPSKSYTHRAILAAGYGDSATIIDPLISADTQATMRAIEAFGGTVEHVDENHIEITGFNGRPRTPTDIINCENSGTTTRLVAACGALADGLCVLTGDESLRSRPHGPLLEAIETLDGRGESTRRNGQAPLIVGDAFQGGSVAIPGDISSQYITALLMAGAVTVDGIDITLETELKSAPYVDITVELLSAFDVTVERTADGFAVPGGQSYTPTDGTYVVPGDFSSISYLLAAGAVAATADGAVIIEGAHPSAQGDSAIVEIIQSMGGQVAWDRNAGELTVPAASLTGITVDVGNMPDLLPTIATLGAIADGDTVINNCEHVRYKETDRVSAMATELGAMGASVTEKHDQLTIHGGETTLSGTHVEGHGDHRIVMSLAIAALAAEGETTISDSEDVDVSFPSFFESLSALGASVQVDR
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_SALSV
Sequence: MSHNDTIVAQATPPGRGGVGILRISGLKARDVAQEVLGKLPKPRYADYLPFKDVDGSALDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTLPGVRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNGVIADLDAVRTEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLRDASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPADIWPDFIARLPKNLPITVVRNKADITGETLGISEVNGHSLVRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALAEAAEHLEQGKAQLLGAWAGELLAEELRLAQQSLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_RHOE4
Sequence: MELVVGRVAKSHGIKGELVVEVRTDEPEDRFAVGSVLRGRKPRESTLKSYTVEAARDHSGRLLLRLEGVSDRGDADALRGTLFVIDSSELEPSDDPDEFYDHELEGLKVVLTDGTEVGSVIEVLHSAAGELLSIRRTGETSGELLIPFVAAIVTSVSIADGVVMIEPPEGLLDPDFGDKSNSDNSNSDND
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_ONYPE
Sequence: MKRTYQPSKIKRKRTHGFRARMATVGGCKVLARRRSKGRLQLTV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: DXS_ECOL5
Sequence: MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNAVGVELTPLEKLPIGKGIVKCRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVSVLNIGLPDFFIPQGTQEEMRAELGLDATGMEAKIKAWLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: US6NL_MOUSE
Sequence: MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPYHNAAADRQKQLEIERTSKWLKMLKKWERYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEFLQETLAKDFFFEDDFVIEQLQVSMAELKRAKLDLPEPGKEDEYPKKPLGQLPPESACVNHLSNGQRSVGRPSPKTSSRREDGSPRKNHEHSPVHHSRNGTPERAGQSRRKSVDEGSKNLKHEAESQRKPSPGMQDSSRHYNHAAANQNSNAISNVRKEFMPKWRKPSDASAIERTTKYAVEGKSHSALPALPVAIPGSAETRLPNSRQKMKALDGGEGKRGSNASQYDNVPGGESEHGASAEEGPERTHPHSPRKHPEPSPSPPKVPNKFTFKVQPPSHVRYPPQLPEEDHRAAYPPSYSNPPVYHGNSPKHVPTAHSGFVSTQISPRPQINPSRRPYGSSLSVDTSPEKAYSRPTPVVLPSSRIEVLPIDMGARGYGSSGSPKNGQFILPPVDYLPENRKWSEVSYTYRPEMHGQSWTRDAHRSHLSNLPNYAAFQHIPFQAHGLPEVSVDSPVRYKMSAAVEDASPPGYPYAGPSPSAHHYRNGEGLSVQESVLL
What is the function of this protein?
Acts as a GTPase-activating protein for RAB5A and RAB43.  Involved in receptor trafficking.  In complex with EPS8 inhibits internalization of EGFR.  Involved in retrograde transport from the endocytic pathway to the Golgi apparatus.  Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network.  Required for structural integrity of the Golgi complex (By similarity).
What are the official names of this protein?
USP6 N-terminal-like protein.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle.
Protein: SOX2_MOUSE
Sequence: MYNMMETELKPPGPQQASGGGGGGGNATAAATGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGGGLNQRMDSYAHMNGWSNGSYSMMQEQLGYPQHPGLNAHGAAQMQPMHRYVVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMAQHYQSGPVPGTAKYGTLPLSHM
What is the function of this protein?
Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285).  Binds to the proximal enhancer region of NANOG (PubMed:15863505).  Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity).  Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669).  Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).  May function as a switch in neuronal development (By similarity).
What are the official names of this protein?
Transcription factor SOX-2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor.
Protein: YIDD_PSYCK
Sequence: MNLFIKIINKYLYKLIYNFIDFYQKIISPILPARCRYYPTCSNYGKQALAWHGVLNGSLLLLKRISRCHPLGGHGVDFVPLPLASYRYQYLSCNPVAHGQFHGFYVYRDNHGYVTRLNHMMKLT
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS17_GLOVI
Sequence: MPRKEKIGLVVSDAMQKTVVVAVENRVPHPKYKKIVVRTRKFKAHDEENRCKVGDRVRILESPPLSKTKRWVVLDILDEARNP
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ISPD_BORPD
Sequence: MTDSLIAIVPAAGVGQRAGRPDLPKQYRLLAGQPMLRWAVAALLADARIGQVRVAVSPGDERAGAALAGLPRTVCRPCGGPTRAATVAAALADSNAADSDWILVHDAARPGLPPDALARLIDACLADAVGGLLALPVADTVKAGGPRVRATLDRDGLWLAQTPQMFRAGVLRAALAAAQAGGGTVTDEASAIEAAGHAPLLVPGAMRNFKVTWPDDFELMEKWL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.