PharMolix/UniProtQA huggingface dataset:
Protein: PCCA_CAEEL
Sequence: MLRAASSIRAVANRGLATAAVARPGVPLDEREGKEIYTTVGIDYNEPKFDKILIANRGEIACRVIKTARAMGIKTVAVHSDVDSNSLHVKMADEAVCVGEAPTAKSYLRADRILQAVEDTGAQAVHPGYGFLSENTKFAAELEKAGAKFIGPNSKAILDMGDKIHSKKIATAARVSMIPGYDGEIADEDMCVKVSRDIGYPVMIKASAGGGGKGMRVAWNDKQAREGYRLSKQEAASSFGDDRMLVEKFIDNPRHIEMQVLCDKHGNALWLNERECSIQRRNQKVIEEAPSSFVPPEMRRKMGEQAVQLAKAVGYDSAGTVEFLVDSQRNFYFLEMNTRLQVEHPITECITGIDIVQQMLRVSYGHPLPITQEQVPLNGWAFESRVYAEDPYKGFGLPSVGRLSRYVEPKHVDGVRCDSGIREGSEISIYYDPLICKLVTHGDNREQALNRMQEALDNYVIRGVTHNIPLLRDIVQEKRFRTGDITTKYLPEVYPEGFQGTSLSPKEQDVVIAFASALNARKLARANQFLNQNKQRSTHVASFSKTYKFVSSLPVKEGERPTEHAVEVEFVEGSANKAQVRIGGKTVTISGDLNLSHPVNSIEVDGEHITTQIVGKRAGEITVLYKGTPFKVKVLPEQAVKYLQYMKEKAKVDLSTVVLSPMPGAIKNVNVKPGDMVSEGQELVVMEAMKMQNSLHAGKTGRVKAVNVKVGATVDEGEVLVELE
What is the function of this protein?
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites.  Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity).  Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity).  Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity).  Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).
What are the official names of this protein?
Propionyl-CoA carboxylase alpha chain, mitochondrial, PCCase subunit alpha, Propanoyl-CoA:carbon dioxide ligase subunit alpha.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PNCB_SALNS
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADAIREQVDAMQHLRLQEDEFQWLSGLPFFKPDYLNWLREFRYNPAQVCVTNDNGKLNIRLTGPWREVIMWEVPLLAVISELVHHYRSPNAGVDQALDALESKLVDFTALTANLDMSRFHLMDFGTRRRFSREVQQAIVKRLQQESWFVGTSNYDLARRLALTPMGTQAHEWFQAHQQISPDLATSQRAALAAWLNEYPDQLGIALTDCITMDAFLRDFGIEFASRYQGLRHDSGDPVAWGEKAIAHYEKLGIDPLTKTLVFSDNLDLQKAVELYRHFASRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPQVRKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: HIS6_PECAS
Sequence: MLAKRIIPCLDVRNGQVVKGVQFRNHEIIGDIVPLAQRYAQEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSVEEAGQILSFGADKISINSPALADPELITRLADRYGVQCIVVGIDTWHDAATGRYHVNQYTGDETRTKVTTWETLDWVEEVQKRGAGEIVLNMMNQDGVRNGYDLHQLNLVRDVCNVPLIASGGAGTMEHFLDAFQTAHVDGALAASVFHKQIINIGELKQYLKQQGVEIRVC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_EHRCJ
Sequence: MVNLPKFTMRDLVESGVHFGHKASRWNPKMAPYIYGVYNDIHIINLQNTVVLLKNALKALYDVVLKRGRVLFIGTKVQASAIIADEAIRCGQYYVNNRWLGGMLTNWETISLSIKKLKEYEKLIENVDNQFTKKELLLFEKKRAKLDRSIGGICNMGGLPHVLFVIDTNKEHIAIKEANKLNIPVIAVLDTNSDPTGIDYPIPGNDDAVRSIDFFCKIVSDTILEAIRSDLAKSGINVDGIKDFSVEKRDDLLRTSNRDNKNNKNNNNTDNTDNAASIKEEDLIGGSNNEN
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: YL006_MIMIV
Sequence: MESKIIKNGCIIIKYERKKRYCKYCEELLPSYLETWKTHHPKCWYKDKRIFINVANSDGHCDELVFYDENKHDNIIKYSRKKITTKHELEEYPIGSLISYTNKKNEFRKAGYVLKYSDNYFIYVTPDFQTKYRVKYKNVLEMWVKKVDSPLKDLIWQAETIQEKTNFPIFIGNKVIYYAKNNSDRDKYMDTTKYKKLVKWYDHFGNNQTLLKFLNTVK
What are the official names of this protein?
Uncharacterized protein L6.
What is the protein family that this protein belongs to?
Belongs to the mimivirus L6/L7/L57 family.
Protein: SH2D5_MOUSE
Sequence: MQRAGAGARRASDCGPAPYRPRCIAKLAQYVGSFPVDDLDTQESVGLVQQQLWALQDCSRRRAVILKFSLQGLKIYSGEGEVLLMAHALKRILYATWYPAACQFAFIARNPRSPSSKLFCHLFVGSQPGEVHILYLLLCRSFQLAYLLQHPEERAQSEPCLAPVGDLSLKPLCSPGVPPALVREPFSRDQLSQNVHALVSFRRLPAEGLLGSNGKELPESEGRGGTRHIRLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGPSCLVENEGSLTENIWAFAGLSRSCALSLLRRDVHGAFLLWPEPGTSDQWSLSVRTQCGVVPHQVFRNHLGRFCLEHLPAEFPSLEALVESHAGVERSLFCPLSMGRLNPTYEEQDCGTEGRFPRTLRPLSHAKSEAELQGLG
What is the function of this protein?
May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.
What are the official names of this protein?
SH2 domain-containing protein 5.
What are the subcellular locations of this protein?
Postsynaptic density.
Protein: RBS_BRADU
Sequence: MKLTQGCFSFLPDLTDDQIYKQVQYCLAKGWAVNIEFTDDPHPRNTYWEMWGLPMFDLQDAAGVMMELAECRRVYGDRYIRISGFDSSPGWESVRISFLVNRPPQEAEFELVRQEVGGRAIRYTTVRKAPAHVS
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
Protein: PGK_BUCAT
Sequence: MTIRKMTELNITEKRILIRSDLNVPIENGIIQSDARILAALPTIELALQKKAKVIIMSHLGRPKEGYYTKKYSLFPIFEYFKKKFNNTKIYFSNNFLDGIKLNPGEIALLENTRFNKGELNNDEQLSKKYSDLCDIFVMDAFGSAHRMQSSTYGIGKFVKIACAGLLLISEIDALKKALKKPKRPMVAIVGGSKVSTKFNVLNKLSKIADTIIVGGGIANTFLAIDYKIGKSLYEPDFVFEAKKLRDKYNIIVPIDSRVGKNFCKNEQAIIKSPDNIKEDEEIMDFGDESIKKIISIITQSQTIMWNGPVGVFEFPNFRKGTEMIAKTIANSNAFSIAGGGDTLSVIDMFNIKNNISYISTGGGAFLEFIEGKKLPAIQMLEENFKNKSK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_ALTMD
Sequence: MKRLNSQLQQDGAPLELILLIRTLLAGCKEISFRVSQGALAGVLGSTLSENVQGETQKKLDVISNHILKDTLRESGYVKAISSEEEDDVVPCDPEGKYLVSFDPLDGSSNTEINSLIGTIFSITHAPQWMKPDDPSAFLQPGTQMVAAGYVLYGPSTMLALTTGRGTHIYTLDKTHGGFLLTHPNIQVPEQTSEFSINASNQRHWEPAMQAYIADLLAGKDGPRGKNFNMRWVAAMVGDIHRLLCRGGIFMYPFDNRDPSKPGKLRLLYEANPMAFLMEQAGGKAETGTGRILEVMPEEIHQRVPCIIGSKEEVDMCLSYNDNAK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_ALIF1
Sequence: MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVKTIAQHIKNSRICGLSRAVAKDIDAAAEALKVAEAFRIHTFISTSTVHVQDKLRRSYDDVVEMGVKAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAIDAGANTINIPDTVGYTVPGEFGGIVQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMILKTRSEYLGVHTNLKHDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDEMGYKEDEYNLDTLYADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYKLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIIEASGQALLHVINSIHRADQIAEIKQKKVETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: IMGH_KRIFD
Sequence: MTTSARDTGLDSHELARLHELARHSHAVITRHQDAGGAYPAAPTFSAYRGYAWLRDGSFTAEGISRYGDVASAGRFHDWVDGVLRRRRGQVDDLLAAVDRGEVPSNEGMLPTRFTFDGNDGSDPWWDFQTDGYGMWLWSVVTHAARHGLDLERWRAGIDVAVDYLLAFWDRPCYDWWEEHVEHRHVSTLGAIHGGLVAVGTCAALRSAPWSAATLQVAARIRSLVSAEGVVDGHLVKWLGSSAVDGSLPACVVPFGLVPPDDDVAAMTRAAVAKDLDVDGGVHRFAADVFYGGGQWILLSALLGWNLAAAGDTAGALRHLRWIADQADADGDLPEQVPHHLLHPGSRAEWVARWGTVATPLLWSHGMYLILADELGLLPPAAKDA
What is the function of this protein?
Involved in the intracellular degradation of the cyclic tetrasaccharide cyclobis-(1-6)-alpha-nigerosyl (CNN) formed extracellularly from starch.  Catalyzes the hydrolysis of alpha-1,6-glucosidic linkage from the non-reducing end of isomaltose to yield beta-D-glucose and D-glucose.  Can also act on panose and isomaltotriose at a lower rate.  It displays low or no activity toward CNN and the general GH15 enzyme substrates such as maltose, soluble starch or dextran.
What are the official names of this protein?
Isomaltose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPI_JASNU
Sequence: MNVLSCSINTLKGLYDISGVEVGQHFYWQIGDFQVHGQVLITSWVVIAILLGSATLAVRNPQTIPTGGQNFFEYVLEFIRDMSKTQIGEEYGPWVPFIGTMFLFIFVSNWSGALLPWKIIQLPHGELAAPTNDINTTVALALLTSVAYFYAGLTKRGLSYFGKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPSVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: COAX_FLAPJ
Sequence: MILTIDVGNTRIKSAVFKYNTIIETAFFSNKNFQSEIENILNLNNKIKVLVVASVGKLEKEAFELFSNRVYVCFISRESTFPFQNNYATQSTLGIDRMVLSAGAVFQFPKKNRLIIDAGTCLTYDFVDENDVYQGGAISPGIRLRYEVMHNYTAKLPLLTLQEPQSLIGNTTNQSLHSGVVNGLTFEIEGYIEAVRGKNENFIIILTGGDANFLAKRLKNTIFANSNFLLESLNNLYQYQK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLUB_DEIAC
Sequence: MGRFIFVSFGLLVVFLSLSGTAADCPSDWSSYEGHCYKPFDEPKTWADAEKFCTQQHKGSHLASFHSSEEADFVVTLTTPSLKTDLVWIGLKNIWNGCYWKWSDGTKLDYKDWREQFECLVSRTVNNEWLSMDCGTTCSFVCKFQA
What is the function of this protein?
Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factor IX (F9) and factor X (F10) in the presence of calcium with a 1 to 1 stoichiometry.  Also inhibits platelet aggregation by binding to platelet glycoprotein Ibalpha (GP1BA) and functioning as a blocker of von Willebrand factor (VWF).  Is devoid of hemorrhagic and lethal activities.  Possesses antithrombotic and thrombolytic activities.  Also hydrolyzes the Aalpha-chain of fibrinogen (FGA).  Does not affect the Bbeta-chain (FGB) and the gamma chain (FGG).
What are the official names of this protein?
Snaclec agkisacutacin subunit B, Agk-B.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARF1_CHLRE
Sequence: MGLRFTKALSRLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNLANKT
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: OBG_FRATF
Sequence: MRFVDEVVIKLQAGKGGNGCVSFRREKYVPCGGPDGGDGGNGGSIYLKADENVNTLIDYRYKREYYAENGRPGEGRNCYGKAGEDLYLVVPVGTSVFDIDTNKKIGEVLQHGQTFKLVSGGKRGIGNTHFKSSTNQAPRKFTLGEEGEYKEVRLELNLLADVALLGLPNAGKSTLIRSVSEATPKVADYPFTTMYPHLGVVKVGVDSFVMADIPGVIEGAAEGAGLGLRFLKHLTRARCVLHVVDICPFNESDPVENYFAVEKELEKYSQELFDKLRFLVINKIDLLADKVEQKCQEFVEQIGYQGNYYTISAAMKKGTDELAKKLNEFLQKQE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_SALTY
Sequence: MTLLALGINHKTAPVSLRERVTFSPDTLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEEQDNLQEALIRWLCDYHNLNEDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHLNASALERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLARQIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQALADEVGAEVISLSDIDARLQDADIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRQAAAVEAETIVEQEASEFMAWLRAQGASETIREYRSQSEQIRDELTTKALSALQQGGDAQAILQDLAWKLTNRLIHAPTKSLQQAARDGDDERLNILRDSLGLE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RLME_RICRO
Sequence: MTNNLSGYRNKFVRVKTSKKRTVSSSNWLRRQLNDPYVAKARIDGFRSRAAYKLLEIHEKFKLFTPNMKVVDLGAAPGGWSQVASKLIKASDNNLNNKIISIDVLEIEHVAGVEFVQKDFFEADTEELIIQALDGRADIVMSDMASNTIGHKATDHIRTLLLCEQAFEFALKVLKPSGHFIAKIFRGGAENELLHKVKREFKTVKHFKPSSSRSESTEIYLVALNKK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_APTPA
Sequence: MAPNLRKSHPLLKMINNSLIDLPTPSNISAWWNFGSLLGICLTTQILTGLLLAMHYTADTTLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLYKETWNTGIILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFMIAGLTLIHLTFLHESGSNNPLGIVANSDKIPFHPYYSTKDTLGFALMLLPLTTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPLLHKSKQRTMTFRPLSQLLFWTLVANLTILTWIGSQPVEHPFIIIGQLASLTYFTILLILFPLIGTLENKMLNH
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MRAY_CHLAD
Sequence: MSVLRAVLVQDMARALLLAAAAFILTLIVGGWWVHFARKHKLGKRIRPDGPQSHLVKVGTPTMGGVMIVSTVVVLTVLFNLVDRWSMLLPLGVMISFAVLGAIDDWLSLTGTRSKTHGFTVRFKFWIMTAVAFVASLALYLPQPYGLEHEGLVQIPFVGEVNIGLWFIPIAVLIIVFISNAVNITDGLDSLAGWNLTLSFGAYGVITFLAEPRLTNLMAFCFTVVGACAAFLWYNAYPAQVFMGDLGALSLGATLAVVALQSQQWILLPVIGIVFVVEALSTLIQTGYFKWTKWRYGEGRRVFKMAPLHHHFELLGWSQPQVTQRFVLIGTVAAMVGISLALIFGSPQSQTQVDQPAMIVQETDGVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UXS2_ARATH
Sequence: MASELINRRHETDQPTADAYYPKPIKPWFTVTRPMRYMLREQRLIFVLVGIAIATLVFTIFPRSTQSTPYSDPFSGYGIRPDESYVPAIQAQRKPSLEYLNRIGATGGKIPLGLKRKGLRVVVTGGAGFVGSHLVDRLMARGDTVIVVDNFFTGRKENVMHHFSNPNFEMIRHDVVEPILLEVDQIYHLACPASPVHYKFNPVKTIKTNVVGTLNMLGLAKRVGARFLLTSTSEVYGDPLQHPQVETYWGNVNPIGVRSCYDEGKRTAETLTMDYHRGANVEVRIARIFNTYGPRMCIDDGRVVSNFVAQALRKEPLTVYGDGKQTRSFQFVSDLVEGLMRLMEGEHVGPFNLGNPGEFTMLELAKVVQETIDPNANIEFRPNTEDDPHKRKPDITKAKELLGWEPKVSLRQGLPLMVKDFRQRVFGDQKEGSSAAATTTKTTSA
What is the function of this protein?
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose.  Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
What are the official names of this protein?
UDP-glucuronic acid decarboxylase 2, UDP-XYL synthase 2, UDP-glucuronate decarboxylase 2, UGD, UXS-2, dTDP-glucose 4-6-dehydratase homolog D18.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: TTRS_SALTY
Sequence: MRGKTVRRLAVLAAVGLLCHGAWAGTWNIGILAMRGEASTRSHWQPLAKTLSQQLPGETFHIQPLDLHQMQEAVNQGTVQFVITNPAQFVQLNSHAPLRWLASLRSTRDGKAVSNVIGSVILTRRDSGITTAHDLIGKTVGAIDAQAFGGYLLGYKALSDAGLRPERDFHLRFTGFPGDALVYMLREKAVQAAIVPVCLLENMDQEGLINKKDFIALLSRPTPLPCLTSTPLYPDWSFAALPAVSDALADRVTRALFNAPAAASFHWGAPASTSQVEALLRDVRQHPQQRRLWLDVKSWLIQHQLMVGGVILAFLLLTLNYIWVMLLVRRRGKQLERNSVVLHQHERALETARQMSVLGEMTSGFAHELNQPLSAIRHYAQGCLIRLRAADEQHPLLPALEQIDQQAQRGADTLRNLRHWVSQAQGNPVLTEAWKAIAIREAIDHVWQLLRMAQQFPTVTLHTEVSAALRVTLPSVLLEQVLANIILNAAQAGATHLWIVAERTENGISIVLQDNAGGIDEALLRQAFQPFMTTRKEGMGLGLAICQRLVRYGRGDISIRNQTAPDGLSGTVVTIHFLHENGGRDGDNSSTG
What is the function of this protein?
Member of the two-component regulatory system TtrR/TtrS, which is required for synthesis of tetrathionate reductase.  Probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue in response to tetrathionate, and transfers its phosphate group to TtrR.  During mice infection, the ability to use tetrathionate as an electron acceptor is a growth advantage for S. typhimurium over the competing microbiota in the lumen of the inflamed gut.
What are the official names of this protein?
Tetrathionate sensor histidine kinase TtrS.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COAA_YERPN
Sequence: MTKREQSLATPYLQFDRTQWAALRDSVPLTLTEEEIVKLKGINEDLSLDEVAQIYLPLSRLLNFYISSNLRRQAVLEQFLGTDGQRIPYVIGIAGSVAVGKSTTARLLQALLSRWPEHRSVELITTDGFLHPNKVLNERGLMKKKGFPESYDMHNLVKFVSEVKSGADYVTAPVYSHLIYDVVPDGNKVIKQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEDLLQSWYINRFLKFRQGAFSNPDSYFHNYAKLPETEAIKIATQLWNEINGLNLKQNILPTRERASLIMTKSANHAVESVRLRK
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_ECOLI
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTAAITGAEGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEASPMVKAKDERRERRDDFANETADDAEAGDSEEEEEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6, Small ribosomal subunit protein bS6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: REV_HV1C4
Sequence: MAGRSGDSDEELIKTVRIIKHLYQSNPPPKPEGTRQARRNRRRRWRERQRRIHSISAWLLSTCLGRSAEPVPLQLPPLERLTLDCSEDCGTSGTQGVGSPQILVESPAVLESGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: GUDIS_GIBF5
Sequence: MVKFDSGSESEMTNGDELHINSKHEVKSRMANGNGVHNVPDHDQFQDRAEMEVLILPDLFSSLMSVPARENPHYASVKADADEWISFVINADAKWASRNKRVDFTYLASIWAPDCSAFALRTSADWNSWAFLFDDQFDEGHLSNDLEGAINEIARTREIMEGTAPRYTADSEHPIRYVFQTLCDRVKQNPEGFYAGKPSSERFYRRWMWAHELYWEGLVAQVRTNVEGRSFTRGPEEYLAMRRGSLGAYPALVNNEWAYGIDLPEEVADHPLVFEIMIIMSDQILLVKDILSYEKDLRLGVDHNMVRLLKAKGLSTQQAINEVGVMINNCYRRYYRALSELPCFGEEADRALLGYLEVEKNHALGSLLWSYNTGRYFKSKEDGARVRKTRELLIPKKMAAL
What are the official names of this protein?
Inactive (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.