PharMolix/UniProtQA huggingface dataset:
Protein: CAS2A_ARCFU
Sequence: MLHLVVYDISDDGSRARLAKLLEKFGLQRVQYSAFRGELNPNDREVLARQVGKFVRDDRDCIFIIPLCQRCSSTAIVISNTGVELVKEKGVEFV
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).  Functions as a ssRNA-specific endoribonuclease.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2 1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: CCA_ACIAC
Sequence: MQIYMVGGAVRDRLLGRPVNDRDWVVVGATPDDLAARGFLPVGRDFPVFLHPETREEYALARTERKSGRGYRGFVVDTAPDVTLEQDLSRRDLTINAMAVRGEDPAAWELVDPYGGARDLQAKLLRHVTDAFREDPVRILRVARFAARFTDFSVAPETMALMREMVDAGEAADLVPERVWQEIARGLMEAAPSRMFEVLRGCGALAVLLPELDRLWGVPQRAEYHPEVDTGVHVMMVLDMAARLHAPLAVRFASLVHDLGKGTTPADVLPRHIGHEQRSATLLADVCERLRVPVECRETADVVAREHGNIHRSAELGAAALVRLLERCDALRKPARFADVLLACECDARGRLGFEETPYPQRQRLLGALQAARSVDTAAVAARAQARGAAGPQVGEWIRRARGDAVQEWMAAQPPAAGT
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: MOAC_BRADU
Sequence: MARKPSKTRPSKAKSGPALTHIGATGEARMVDVSDKPATERLAVAEGRVLMTRATLDLIVSGNAKKGDVLGTARIAGIMAAKRTSELIPLCHPLALSKVTVDIEPDAKLPGCLVRASVKVTGPTGVEMEALTAVSVACLTIYDMIKAVERGVRIEGIHLVEKLGGKSGHYRA
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: MOGT1_BOVIN
Sequence: MKVEFAPLNIPLARRLQTAAVLHWLLSFLLFAQVCLGIIVFLIIYNYWFLYLPYLTWLYFDWQTPEQGGRRSEWVRNWAIWRYFKDYFPIHLIKTWDLDPSHNYIFGFHPHGVLVVGAFGNFCTNYSAFKELFPGFTSYLHVLPYWFRCPLFREYLMSSGPVSVSKKSVCHVLSKEGGGNISVIVLGGAEESLDAHPGKFTLFIRQRKGFVKIALTHGAYLVPVFSFGENELFKQVSNPEGSWLRNVQEKLQKIMGFALPLFHARGIFQYNFGLIPYRKPIHTVVGRPIPVRQTLNPTSEQIEELHQTYMEELRKLFEEHKGKYGIPENETLIFR
What is the function of this protein?
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA.  Probably not involved in absorption of dietary fat in the small intestine.
What are the official names of this protein?
2-acylglycerol O-acyltransferase 1, Acyl CoA:monoacylglycerol acyltransferase 1, MGAT1, Monoacylglycerol O-acyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RSMG_CHESB
Sequence: MMAERFSALQAVAGPVSRETFDGLVAFEGEFRKWSARINLTAPSTLPHLWERHILDSAQLIRIAPAARRWLDLGSGGGFPGAVIAILMKEHAPAQVDLVESNRKKAAFLQTSLASLKAPCMIHPQRIEDCYGQIPPPEVITARALAPLPVLFGLAEPWMKAGARALLHKGRDYRREIEESRDAWGFNLLEHGNEVGGDGVILEISDLRRL
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KU_BRASO
Sequence: MAPRAYWKGSLKLSLVTCPVVLYPASTSVEKTRFHLINRETGNRLKQQMIDAETGDLVEGDQKGRGYELSKGQYVEIEPEELEAVQIESNHTIDIDSFVPREEIDQRYLNHPYYIAPDGKAAVDAFAVIRDAMKDQDRVALARIVLTHREHVIAIEPMGKGMLGTTLRFPYELRDEAEFFDDIKAPKITKDMVELAGHILQTKAAHFKPSEFKDQYETALKALVKRKASGKPIKLPEPEERSGNVVSLMDALKQSLGKGDKKAAPAPSRRAPAHRRPAKKAHRSAARQRKAG
What is the function of this protein?
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity.  Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA.  Recruits and stimulates the ligase activity of LigD.
What are the official names of this protein?
Non-homologous end joining protein Ku.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic Ku family.
Protein: EF1A2_DROME
Sequence: MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSEARYEEIKKEVSSYIKKIGYNPASVAFVPISGWHGDNMLEPSEKMPWFKGWSVERKEGKAEGKCLIDALDAILPPQRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGLLKPGMVVNFAPVNLVTEVKSVEMHHEALTEAMPGDNVGFNVKNVSVKELRRGYVAGDSKNNPPRGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFSEIKEKCDRRTGKTTETEPKAIKSGDAAIIVLVPSKPLCVESFQEFPPLGRFAVRDMRQTVAVGVIKSVNFKETTSGKVTKAAEKAQKKK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha 2, EF-1-alpha-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP2A4_YEAST
Sequence: MELDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNKYGGNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNNPTLDHPDNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEEAPENKLLKENSMNDNALEDSISNPVANRKLIADYFEDDSASADGSTDPEMYIFSDVYQARSASNRHVDYFL
What is the function of this protein?
Involved in glycogen accumulation.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP2A-like PPG1.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-2A subfamily.
Protein: 209L2_MACMU
Sequence: MSDSKEPRAQPLGLLEEEELITSSMNFFPRDFGFRQTRGYKSLAGCLGHAPLVLPLLFFTLFTGLLVAILVQVSKNPSSQRLDQSKQDEISQDLSQLKAAVERLCRPCPWEWTFFQGNCYFISNSQRNWHDSITACQEVGAQLVVIKSAEEQNFLQLQSSRSNRFAWMGLSDLNQEDMWQWVDDSPLSTSFKQYWNRGEPNNIGEEDCVEFNGNGWNDDKCSAAKFWICKKSAASCSRDEGQLLSSASASPIAHAA
What is the function of this protein?
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver.  May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments.  Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.  Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity).
What are the official names of this protein?
CD209 antigen-like protein 2.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: IPYR_HALH5
Sequence: MAIEPKVIEAFIEIPTGSQNKYEYDKERGVFKLDRVLFSPMFYPAEYGYIENTLALDGDPLDVLVIVSNPTFPGCVIDAKVLGFLNMIDGGEEDQKLIAVPTEDPRFKDVNSLNDLPKHKLDEIAHFFKTYKDLEGKKTEVGAYEDAEAAAKLIDECFARYKG
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
Protein: TRPF_BACAA
Sequence: MKVKICGITDMETAKRACEYGADALGFVFAESKRKITPGLAKEIIQELPANVLKIGVFVNESVEVIQKITGNCGLTHVQLHGGEDNHQIRRLNIPSIKSLGVTSESDMKNAQGYETDYILFDSPKEKFHGGNGKTFPWELLAHMPKELREKTILAGGLNTLNIEEAIRTVRPYMVDVSSGVETEGKKDVEKIKQFIIKAKECSK
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: CLPS_PSEA6
Sequence: MSKDNTINIEREKQLDTVKQKLAPPPMYKVLLNNDDYTPMDFVIEVLVRFFNLDSEKAHQIMLTVHYRGRAVCGVYTAEIAETKVMQVTQYAKKHQHPLMCTMEQV
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: M1I1B_DANRE
Sequence: MMQICDSYNQKNSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLDQEEEKEVTSFQDGDMYGSYVLLKSIRNDIEWGVLQAEERRKEKHGVTTTSLEVSRIEPNDKDLEKLFHYHLSGLHTVLAKLTRKANTLTNRYKQEIGIGGCGN
What is the function of this protein?
Involved in stabilization of microtubules.  May play a role in the regulation of lipogenesis (By similarity).
What are the official names of this protein?
Mid1-interacting protein 1-B.
What is the protein family that this protein belongs to?
Belongs to the SPOT14 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Protein: PRP28_MAGO7
Sequence: MAPLDLEEILKKHKAAKAEAAKPRFIPRGQRKKMEEEKKLKVEEEQKRQQEELQKTRSELQKAREELAGLQRVRRQEQSRSRESDHSVPTGPRAMRSYDDDSFNGNGNGSNSNRNNNNNQRDRQDASTKTNGSRTAEEVQEEKKYLERYTGPPAKVSTFSANKKRRRTTDQKFNFDWDPKDDTSQPWRYEETGAHERSANGATEQVRRKKATRDYNDPRLVPWQDKELSQMTTRDWRLFKVNLEIVTKGNNIPNPMRFWEESNLPHVLKDTIKQVGYTEPTPVQRAAIPIALQCRDLIGISKTGSGKTAAFVLPMLSYIEPLPPLNEVTKTEGPYALILAPTRELATQIQAEVIKFATRMGFTVVCLIGNKRTIEEDAFALRNGAEIIVATPGRLVDCLERHLLVLSQCSYVVLDEADRMVDGGFEDSIHKILAALPPSNGKPDDRDAEDPNIMSKFLTPNLRYRQTVMYSATMPPSVERIAKNYLKHPAMVTIGTIGEAVDTVEQQAMWVVSEDERRNKLRAMLNTYGTGKLVIVFVNTKSNCDAVAKDLKSSSFSAVTLHGNKTQDQREAALQSFRDGRTNVLVATDVAARGLDIPDVSLVINFNMAGTIEVYTHRIGRTGRAGKEGMAITFCGPEDHGVLYHLKQIMSKSQMSKVPPWLKDHPEAQSKPTF
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA splicing.  May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site.  May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CP242_PIG
Sequence: CDPTFILDCAPCNVICSIIFQNRFDYTDQDFLTLLEKFHENLNILSSPWIQVCNNFPALIDYSPGIHNKLLKNIAYLKSYVLKKVKEHQESLDINNPRDFIDCFLIKMEQEKHNQQSEYTIENLIATVSDMFSAGTETTSTTMRYGLLLLLKHPEVTAKVQEEIDRVIGRHRSACMQDRSHMPYTDAVVHEIQRYIDLVPTNLPHAVTCDIKFRNYLIPKGTTILTSLTSVLYDCKAFPNPEVFDPGHFLDESGNFKKSDYFMPFSTGKRICVGEGLARMELFLFLTTILQKFNLKSVVDPKDIDTTPVANGFASVPPFYQICFIPL
What is the function of this protein?
Cytochromes P450 are a group of heme-thiolate monooxygenases.  In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.  It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
What are the official names of this protein?
Cytochrome P450 2C42, CYPIIC42.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: ARGJ_YEAS1
Sequence: MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: LSRK_YERPS
Sequence: MSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLTTNWQLTCQCIRQALHLAKLPASAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSAMPRLLWLAHYRPDIYRQAGTLTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTLLGHVTAKAAQECGLLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHVIPGMVQAESISFFTGLTMRWFRDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEKCNKATLFRALEENAAIVSACNLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVGVGLYEALDKTGERLVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPGL
What is the function of this protein?
Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon.  Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
What are the official names of this protein?
Autoinducer-2 kinase, AI-2 kinase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKM3_YEAST
Sequence: MKESLLTLTEKIMFTTTVLKPTITTPITMLITTMRTLVAMKIRHYWKMMAIKDRKIQIPPVKYQMELSIRTLEINLLKNVKETEANLLKRRTDRENKRHYEFGFFYNLRIHNIYIPTSFFFFNSIV
What are the official names of this protein?
Putative uncharacterized protein YKL123W.
Protein: IPYR_RICPR
Sequence: MFIKKIKAKANNNEINVIIEIPMNSGPIKYEFDKESGALFVDRFMQTTMSYPCNYGFIPDTLSNDGDPVDVLVVAHHPVVPGSVIKCRAIGVLMMEDESGLDEKIIAVPTSKLDITFDHIKELDDLCEMLKKRIVHFFEHYKDLEKGKWVKVTGWGDKVKAETLIKEGIDRN
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C71P1_ORYSJ
Sequence: MELTMASTMSLALLVLSAAYVLVALRRSRSSSSKPRRLPPSPPGWPVIGHLHLMSGMPHHALAELARTMRAPLFRMRLGSVPAVVISKPDLARAALTTNDAALASRPHLLSGQFLSFGCSDVTFAPAGPYHRMARRVVVSELLSARRVATYGAVRVKELRRLLAHLTKNTSPAKPVDLSECFLNLANDVLCRVAFGRRFPHGEGDKLGAVLAEAQDLFAGFTIGDFFPELEPVASTVTGLRRRLKKCLADLREACDVIVDEHISGNRQRIPGDRDEDFVDVLLRVQKSPDLEVPLTDDNLKALVLDMFVAGTDTTFATLEWVMTELVRHPRILKKAQEEVRRVVGDSGRVEESHLGELHYMRAIIKETFRLHPAVPLLVPRESVAPCTLGGYDIPARTRVFINTFAMGRDPEIWDNPLEYSPERFESAGGGGEIDLKDPDYKLLPFGGGRRGCPGYTFALATVQVSLASLLYHFEWALPAGVRAEDVNLDETFGLATRKKEPLFVAVRKSDAYEFKGEELSEV
What is the function of this protein?
Involved in serotonin biosynthesis.  Catalyzes the conversion of tryptamine to serotonin (PubMed:21080162, PubMed:23053415, PubMed:20150424, PubMed:23521226).  Accumulation of serotonin may play a role in innate immunity (PubMed:20150424).
What are the official names of this protein?
Tryptamine 5-hydroxylase, Cytochrome P450 71P1, Protein SEKIGUCHI LESION.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RLIG_THEA1
Sequence: MEITLEKALKEIEGNKFFKVLKENDLVKVSYRFNAPQTFDTPLKRELRGITFSSKTGRVVSRPFHKFFNLGEHPETEKERLKGKLFILREKLDGTMLHPAVVEGRVRLFTQKDFANPQIEKGEELLRRNDKLLKATRRLLEKGLTPIFELISPEFQLVIPYETEELILTEVRDNRTGHYLLEEAENELIQMGFKLPRKRVGTVEEAERLIEEAENVEGFVAKNFDESEPFPLFVKIKSPWYHRAHYAFTYLHNIPDHKLFNLFLNNRADDIFATVTNPAVKEKKSRRLKILTDIYHSLLSSAEKLSQLYGKVKEETLKAEAQKELKKIEREFKEELKLFNFPVEHLTEAARLAKQKKKFDKFLGTKLYTALKHQTVKLKT
What is the function of this protein?
Putative RNA ligase (PubMed:25324547).  Is able to catalyze the adenylation reaction of ssDNA 3'-terminal phosphate (ssDNA 3'p) to 3'-adenylated DNA (ssDNA 3'pp5'A) (PubMed:25324547).
What are the official names of this protein?
Putative RNA ligase, T4 Rnl1-like protein.
Protein: RLMN_BRUME
Sequence: MSISFDLTIDDTRDQLARHARASLEAKPSLIGMSREEMAAALIAAGVPERQVKMRISQLWHWLYVRGVSDFADMRNISKDLRAMLAQHFTIARPEVVEEQISQDGTRKWLFRFPPRGAGRPVEIESVYIPEEGRGTLCISSQVGCTLTCSFCHTGTQKLVRNLTSEEILAQLLTARDRLGDFPDKDTPDGAMVPAEGRKITNIVMMGMGEPLYNFEEVKKALLIASDGDGLSLSKRRITLSTSGVVPEIYRTGDEIGVMLAISLHAVRDELRDILVPINKKYPLAELIKACREYPGLSNAKRITFEYVMLKDINDSLDDAKLLVKLLQGIPAKINLIPFNPWPGTNYQCSDWEQIEKFADYVNAAGYASPIRTPRGRDILAACGQLKSESERLRKSERLALEAMMIAGHGE
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_METKA
Sequence: MRSVEYLAYLRSKYGIRPRRRLGQHFMVDDNILEFMVEAAEVREDDIVLEIGPGPGLLTRYLMTRAGQVIAVELDGRMVEILKRELGEAPNLEIVRADFLEYDVPDDVNKVVANIPYNISSPITFKLLELDIDVAVLTYQREFAERMVAEPGSKKYSRLTVMVNLLADVELLRGVPRRAFIPPPRVGSSVVRLTPKSEEERPDVDPDTLESVCRALFQHKNKTVRNALLLSAHEWATDREQAREVLEELPEDLLSERPLHLPPERVAELAAAIESALG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Probable ribosomal RNA small subunit methyltransferase A, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLD10_XENTR
Sequence: MAAEAGGGEPLVKFVKLSGRAAGSKKKVRWFPVRRLFTHSCPSLRIPSRFLREGRRSPPARSGHRCVADNTNLYVFGGYNPDYDESGGPENEDYPLFRELWRYHFATGMWHQMGTDGHMPRELASMSLVLHGHNLLVFGGTGIPFGESNGNDVYVCNVKYKRWSKLNCRGKKPNRIYGQAMAIIHGFLYVFGGTTGYIYSTDLHRLDLSTREWIQLKPNNPPCDLPEERYRHEIAHDGQRIYVLGGGTSWTAYSLEKIHAYNFETNTWEDIPTKPYGNLGFPAARRCHSCVQIKNEVFICGGYNGLVILGDLWKLDLQTFQWTKLPALMPEPAYFHCAAVTPAGCMYIHGGVVNIQQNKRTGSLFKIWLVVPSLLELCWENLLKYFPHLCQLPTHQLLQLGLSQELIERLK
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) at the C-terminus, leading to their ubiquitination and degradation.  Participates in the oxidative stress-induced cell death through MAP3K5 activation.
What are the official names of this protein?
Kelch domain-containing protein 10.
Protein: YQGF_PROA2
Sequence: MTKENRKRIIAVDYGTKRIGLAKTDPLQLFAQPVGTFSEEALFRAIKEISGLDGIGRILIGYPLNADGSHNRMTDIVDAFAARVHNEFPDIPLELVNEHGSSRSAGQILINSGLSRKKRHEKGRLDSASACVLLQAHLDKSH
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASIC1_MOUSE
Sequence: MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEACSAEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAKRNSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
What is the function of this protein?
Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized.  Generates a biphasic current with a fast inactivating and a slow sustained phase.  Has high selectivity for sodium ions and can also transport lithium ions with high efficiency.  Can also transport potassium ions, but with lower efficiency.  It is nearly impermeable to the larger rubidium and cesium ions.  Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis.  This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury.  Heteromeric channel assembly seems to modulate channel properties.  Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines.  Modulates activity in the circuits underlying innate fear.
What are the official names of this protein?
Acid-sensing ion channel 1, ASIC1, Acid-sensing ion channel, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2.
What is the protein family that this protein belongs to?
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.
Protein: ATPG_BORPD
Sequence: MPGIKEIRTKIKSVQNTRKITKAMEMVAASKMRKAQDRMRAGRPYATKVREIAAHLMQANPEYSHPYLVEREIKAVGVVLVTTDKGLCGGLNTNISRVTLAKLKEFDQRGIRVQATAFGNKGLGLLTRIGANLVSHEVQLGDKPDLDRLLGAIKVQLDAYLSGEIDALYVAATRFVNTMKQEPVFLRLLPLASGLDDPFQTGAETLADGAEVKSNYSWDYIYEPDAKSVIDDLLQRYVEGLLYQAVAENMASEQSARMVAMKAASDNAKKVIGDLQLVYNKTRQAAITKEISEIVGGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.