PharMolix/UniProtQA huggingface dataset:
Protein: FBLN5_PONAB
Sequence: MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGRYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
What is the function of this protein?
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN.  Stabilizes and organizes elastic fibers in the skin, lung and vasculature.  Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif.  Vascular ligand for integrin receptors which may play a role in vascular development and remodeling.  May act as an adapter that mediates the interaction between FBN1 and ELN.
What are the official names of this protein?
Fibulin-5, FIBL-5.
What is the protein family that this protein belongs to?
Belongs to the fibulin family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.
Protein: HIS4_MYCPA
Sequence: MLILLPAVDVVDGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVRVELSGGIRDDDSLAAALATGCARVNLGTAALENPQWCARAIGEHGDKVAVGLDVQIIDGQHRLRGRGWETDGGDLWEVLERLERQGCSRYVVTDVTKDGTLGGPNLDLLGAVADRTDAPVIASGGVSSLDDLRAIATLTGRGVEGAIVGKALYAGRFTLPQALAAVAE
What is the function of this protein?
Involved in both the histidine and tryptophan biosynthetic pathways.
What are the official names of this protein?
Phosphoribosyl isomerase A, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, N-(5'-phosphoribosyl)anthranilate isomerase, PRAI, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F107A_RAT
Sequence: MARAGPEYREWNSELIKPKKLLNPVKASRSHQELHRELLMNHKRGLGMDRKPELQRVLEHRRRNQLIKKKEEELEAKRMQCPFEQELLRRQQRLNQLENPPQREEDHAPEFIKVRENLRRITTLTSEERAL
What is the function of this protein?
Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics.  Mediates polymerization of globular actin to F-actin.  Also binds to, stabilizes and bundles F-actin.  Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity).  Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner.  Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner.  May play a role in tumor development (By similarity).
What are the official names of this protein?
Actin-associated protein FAM107A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Cell projection, ruffle membrane. Synapse. Cell projection. Note=Colocalizes with F-actin and COMMD1 in the nucleus. Colocalizes with MAP1A along actin stress fibers and membrane ruffles.
Protein: ATPB_GEOUR
Sequence: MSQNIGKISQVIGAVIDVEFEPGKLPPIYNALRVTNPSIDDKENNLVLEVAQHLGENSVRTIAMDSTDGLVRGQAAIDTGKQISVPVGRKTLGRILNVIGDPVDEMGPVGAEKEYGIHREAPAFVDQSTKVEAFTTGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIMELINNIAMQHGGFSVFAGVGERTREGNDLWMEMKESGVLEKTALVYGQMNEPPGARARVALSALSIAEYFRDEEGQNVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGELQERITSTNKGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLSRQIAELGIYPAVDPLDSTSRILDPQVIGEEHYAIARQVQYVLQKYKDLQDIIAILGMDELSEEDKLVVARARKIQRFLSQPFHVAEAFTGAPGKYVELKDTIKGFQEIVAGKHDDVPEQAFYLVGTIEEAIEKAKTLAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HUTU_VIBC1
Sequence: MTQRQGQDPRLDTSRTIRAPHGTQLRAKSWLTEAPLRMLMNNLDPDVAEHPHSLVVYGGIGRAARNWECFDKIVEVLERLDDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKEGLMMYGQMTAGSWIYIGSQGIVQGTYETFVSVAKKHFNGDAKGRWILTGGLGGMGGAQPLAGTMAGFSMIAVECDESRIDYRLRTGYVDKKATSLDEALAMIKESDTPISVGLLGNAADIFPQLVERNITPDVVTDQTSAHDPLNGYLPQGWSMSHAAEMRLQDEADVVKTAKKSMAVQVKAMLELQKRGAATLDYGNNIRQMALEEGIENAFDFPGFVPAYIRPLFCEGIGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARERIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPVVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGFSQHSGMVICCDGSDDASERIARVLHNDPATGVMRHADAGYDIAKQCAAEQKLDLPMLNEELKKLK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNB_ECOLC
Sequence: MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPWWVTLARHNLEKEAPDGVATEMLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSKLDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFFAATIESKAKLVYDQVSDWLENTGDWKPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDEMVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYC_AVIMH
Sequence: MPLSVSLPSKNYDYDYDSVQPYFYFEEEEENFYSAAQQRSSELQPPAPSEDIWKKFELLPAPPLSPSCRSNLAAASCFPSTADQLEMVTELLGGDMVNQSSICDPDDESFVKSIIIRDCMWSGFSAAAKLEKVVSEKLATYKASRREGGPAAASRPGPPPSGPPPPPAGPAASAGLYLHDLGAAAAGCIGSSVVFPCPLGRRGPPGAGPAALLGVDAPPTVGGGSEEEQEEDEEIDVVTLAEANESESSTESGTEASEEHCKPHHSPLVLERCHVNIHQHNYAAPPSTKVEYPAAKRLKLDSGRVLKQVSNNRKCSSPRTSDSEVNDKRRTHNVLERQRRNELKLSFFALRDQIPEVANNEKAPKVVILKRATEYVLSIQSDEHRLIAEKEQLRRRREQLKHKLEQLRNSRA
What is the function of this protein?
Transforms avian and murine macrophages and fibroblasts as well as murine B-lymphoid cells.
What are the official names of this protein?
Viral myc transforming protein, v-Myc.
What are the subcellular locations of this protein?
Host nucleus.
Protein: C1QT6_HUMAN
Sequence: MQWLRVRESPGEATGHRVTMGTAALGPVWAALLLFLLMCEIPMVELTFDRAVASGCQRCCDSEDPLDPAHVSSASSSGRPHALPEIRPYINITILKGDKGDPGPMGLPGYMGREGPQGEPGPQGSKGDKGEMGSPGAPCQKRFFAFSVGRKTALHSGEDFQTLLFERVFVNLDGCFDMATGQFAAPLRGIYFFSLNVHSWNYKETYVHIMHNQKEAVILYAQPSERSIMQSQSVMLDLAYGDRVWVRLFKRQRENAIYSNDFDTYITFSGHLIKAEDD
What are the official names of this protein?
Complement C1q tumor necrosis factor-related protein 6.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPA_OCEIH
Sequence: MNFGKVLTAMVTPFDKHEEIDFQALDHLIDHLINNGSDGLVVAGTTGESPTLTHEERIKLFEYVVKKVNGAVPVIAGTGSNYTKASIELTKEVAKTGVDGVMLVAPYYNKPSQDSMYEHFKVIAESTELPVMLYNVPGRTGVDMDVSTVVRLSQIDNIVSIKDASGNLEKMTNIIRLTDDNFSVYSGEDSLTLPALAIGADGIVSVSSHIIGNDMQEMIQRFEQGQVAEAANIHQRVLPVMQEMFANPSPVPVKTALNLQSVPVGKVRLPLIELTDEQLQNLQSVLSDFEHSKMI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F110A_BOVIN
Sequence: MPVDTLTPGARDTPALPIRLRTKVPGYLLRRPADGGARKPSAVERLEADKAKYVKSLHVANTRQEPVQPLLCKQPLFSPGTRRTVLTPSRRALPGPGCRPQLDLDILSSLINLCDSPVSPAEASRTPGRAEGARQPPLATPPRPPPSIAAVRRVDVLPLPASPIQPCPSPGPAAASSPVRPPGLQRSKSDLSERFSRAAADLERFFNFCGLDPEEARGLGVAHLARASSDIVSLAGPSAGPASSEGGCSRRSSVTVEERARERVPYGVSVIERNARVIKWLYGLRQARETPAAEC
What are the official names of this protein?
Protein FAM110A.
What is the protein family that this protein belongs to?
Belongs to the FAM110 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles.
Protein: Y2247_DESHY
Sequence: MAGQNRNKDFLIVSKDILPEAILKTAQAKELLVKGDANTINEAVDRVQLSRSAFYKYKDGVFPFYEASREKIITFSLTLENTAGVLSNVLNTIARFKANVLTINQGIPLQGIANVTISVENMGMVDIPENLLSALGEIDGVRKIEVIGQN
What are the official names of this protein?
UPF0735 ACT domain-containing protein DSY2247.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: ACP_XANAC
Sequence: MSTIEERVKKIVVEQLGVKEEEVTTSASFVDDLGADSLDTVELVMALEEEFECEIPDEEAEKITSVQQAIDYVKAHVKS
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC9_XENTR
Sequence: MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
What is the function of this protein?
Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4.  Essential for nuclear architecture and chromosome segregation.
What are the official names of this protein?
SUMO-conjugating enzyme UBC9, RING-type E3 SUMO transferase UBC9, SUMO-protein ligase, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin-conjugating enzyme E2 I, Ubiquitin-protein ligase I.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL13A_PONAB
Sequence: MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTSPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLVRLRKQAEKNVEKKIDKYTEVLKTHGLLV
What is the function of this protein?
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions.  Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.  Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.  In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex.  Involved in methylation of rRNA.
What are the official names of this protein?
60S ribosomal protein L13a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPO11_CAEEL
Sequence: MYEYSFNPNIDHEPGSVESQQSTIYSDSDDSDDSFLDDEVIPPKEQAMRKIEFALADIKRQMDNKEKSLTLRISTSKSHFCLRYTAKRKGKLDRDLHCLHQVYDLLENDKRSTKRELYYEHKAVYGNQKYLDSSIKSICELLNESRANLNILSCGRGIIRGAITFLVENVGVIDARVQEVLITDALLFSNIISEADFILVVEKDTTFQKLMDENFQAMFPRGILATSKGYPDIATRNVLKMLSEKRKFPIYGLFDADPHGIEIYLTYKYGPTKEFAEGRGAFVPTIEWIGLFPTDFHRFTIDQSQCLPLVRTDFVKIEKMIPRSIQLGEIVVTRELDWMIQNKFKMELESINMCGQEYMARFLIAPRVMSIEKEIPIQPETIINEYHEDSQCSLSTDDDREAKDDDYIDSDAEEKFQNMIDNDSD
What is the function of this protein?
Required for meiotic recombination.  Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.
What are the official names of this protein?
Meiotic recombination protein spo-11.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCSP_ROSDO
Sequence: MSFKPIDYLPYDFANRRHIGPSPAEMTQMLEVTGAANLDALMDDTLPAAIRQKEPLAFGKAMSEREVLEHLRRVASKNQVLTSLIGQGYYGTVTPPAIQRNILENPAWYTAYTPYQPEISQGRLEALLNFQTMVSDLTGLEVANASLLDEATACAEAMTMAQRVSKSKSKAFFVDRDCHPQNIAVMQTRAAPLGIEIIVGNPDKMDAEAVFGAIFQYPGTYGHVNDFTDHMAALHAHKAIGIVSADPLALTLLKEPGAMGADIAVGSTQRFGVPEGYGGPHAAYMACRDAYKRAMPGRIVGVSVDSHGHRAYRLSLQTREQHIRREKATSNVCTAQALLAVMASMYAVFHGPEGLRAIAQRIHRKAVRLAKGLEEAGFTVDPQAFFDTITVDVGPLQAAVMKSAVDEGINLRRVGETRVGISLNERCRPDTLEAVWRAFGITRADNDFRPDYRFPEEMLRTSDYLTHPIFHMNRAETEMMRYMRRLSDRDLALDRAMIPLGSCTMKLNSAAEMMPVSWRDFSLLHPFAPVDQAKGYTEMIDDLSAKLCQITGYDQISMQPNSGAQGEYAGLLSIAGYHRANGEAHRNICLIPMSAHGTNPASAQMVGWTVVPIKSADNGDIDMADFAAKAEQHAANLAGCMITYPSTHGVFEETVTEVTRITHQHGGQVYIDGANMNAMVGLSRPGDLGGDVSHLNLHKTFCIPHGGGGPGMGPIGVKSHLAPFLPGHEMTGGGEGAVSAAPFGSPSLLPISWAYCLMMGGDGLTQATRVAILNANYIAKRLEGAFDVLYRGPTGRVAHECVIDVRPFEKSAGVSVEDIAKRLIDCGFHAPTMSWPVAGTLMVEPTESETKAELDRFCDAMLAIRAEIADIEEGRMDAANNPLKNAPHTVDDLVSDWDRPYSRDQGCFPPGAFRVDKYWPPVNRVDNVFGDRHLVCTCPPMEDYAEAAE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: OCR1_HUMAN
Sequence: MPVAPSNHCDNQCPHIFSKALVVSVAPSPPRDKPAPYTFTDVSSLCGLQKKCEGGKAMLFTLKRDRFSFLLFVSHC
What are the official names of this protein?
Ovarian cancer-related protein 1.
Protein: DAD1_DROME
Sequence: MVELSSVISKFYNDYVQNTPKKLKLVDIYLGYILLTGIIQFVYCCLVGTFPFNSFLSGFISTVSCFVLAVCLRLQANPQNKSVFAGISPERGFADFIFAHVILHLVVMNFIG
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity (By similarity).  Probably as part of the N-glycosylation pathway, plays a role in the regulation of tissue growth and apoptosis (PubMed:27693235).
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, DAD-1, Oligosaccharyl transferase subunit DAD1, Defender against apoptotic cell death 1, Defender against cell death 1.
What is the protein family that this protein belongs to?
Belongs to the DAD/OST2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SIT_SEGFL
Sequence: RQDMVDESVCYITDNNCNGGKCLRSKACHADPWEL
What is the function of this protein?
Insecticidal toxin.
What are the official names of this protein?
U1-segestritoxin-Sf1a, U1-SGTX-Sf1a, Insectotoxin SIT.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 16 (SFI) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PLCG1_BOVIN
Sequence: MAGAASPCANGCGPSAPSDAEVVHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRAGERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSIWNSQLDEVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASGSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAVRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSVMRDEAFDPFDKSSLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEGLELASLLVKIDVFPAKQENGDLSPFGGASLRERSCDASGPLFHGRAREGSFEARYQQPFEDFRISQEHLADHFDGRDRRTPRRTRVNGDNRL
What is the function of this protein?
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).  Plays an important role in the regulation of intracellular signaling cascades.  Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity).  Plays a role in actin reorganization and cell migration (By similarity).
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1.
What are the subcellular locations of this protein?
Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Protein: MIAB_RHIL3
Sequence: MTQDSALLQAPEAIPSESLRDGSNSRKVFIKTYGCQMNVYDSMRMSDALARDGYEPTEDMEVADLVLLNTCHIREKAAEKVYSALGRLREMKKKKAADGREMMIGVAGCVAQAEGEEILRRAPAVDVVIGPQTYHRLPEALRRAKQGQRVVDTEYAIEDKFEHLPIAESRRIRARGVTAFLTVQEGCDKFCTFCVVPYTRGSEVSRSVSQIVEEAEKLADSGVREITLLGQNVNAWHGAGSQGEAWSLGDLLYRLAEIPGLARLRYTTSHPRDMDDRLINAHRDLSALMPYLHLPVQSGSDRILKAMNRRHTAAEYLALIERIRTVRPDIALSGDFITGFPGETDEDFKDTLRLVEEVRYAQAFSFKYSTRPGTPGAELKDQVPEEIKAERLERLQMLLLKQQQEFAESCVGKEIDLLLEKPGRMPEQLIGRSPWLQSVNVDAKASQIGDIIKVRITGTGTNSLFAEHAEAAV
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHDH_MACFU
Sequence: MALRWGIVSVGLISSDFTAVLQTLPRSEHQVVAVAARDLSRAKEFAQKHDIPKAYGSYEELAKDPNVEVAYVGTQHPQHKAAVMLCLAAGKAVLCEKPMGVNAAEVREMVTEARSRGLFLMEAIWTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLTHVPRAVDWAQAGGALLDLGIYCVQFISMVFGGQKPEKISVMGRRHETGVDDTVTVLLQYPGEVHGSFTCSITAQLSNTASVSGTKGMAQLLNPCWCPTELVVKGEHKEFLLPPVPKNCNFDNGAGMSYEAKHVRECLRKGLKESPVIPLVESELLADILEEVRRAIGVTFPQDKH
What are the official names of this protein?
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, D-xylose 1-dehydrogenase, D-xylose-NADP dehydrogenase, Dimeric dihydrodiol dehydrogenase, Jmo2DD.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: CBIT_METMP
Sequence: MIQDSEFFRMEGVPITKEEIRAVSIGKLNLDPEDVVLDIGCGSGGMSVEISKRSKFVYSIDNSEDAKNTTLNNLKKFNVENCTVSLGNAEDLISKFDFNKVFIGGTQNIEQILEILKEKNIERIVVNTIVLENSVKIINKFEELGYNVDFVNVSVSYGKKINSGHIMLSKNPITIITATLK
What is the function of this protein?
Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
What are the official names of this protein?
Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating).
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
Protein: LOLB_CITK8
Sequence: MTLPDFRLIRLLPLASLVLTACTINAPKGPGKSPDSPQWRQHQQDVRKLNQYQTRGAFAYISDDQKVYARFFWQQTGQDRYRLLLTNPLGSTELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLTGMPIPLNSLRQWILGLPGDATDYTLDDQYRLSEVNYHQDGKNWKVVYSGYDSKTQPAMPANMELSDGSQRIKLKMDNWIVK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TRPC_ARATH
Sequence: MEGLVPVQRLPIKVASPSLYRCNNSVSIRRSISGFAMDRKINFRAPSQFSIRAQQSDLKESLAVSSSSVEDKGNVLRIKEWEVEMYQEELAISQGIRIRRKPPSKAPLGYSGPFELRLHNNDADSPRNILEEITWYKDVEVSRMKELNPLDVLKKAVEDAPPTRDFVGALRMAHKRTGFPGLIAEVKKASPSRGILKENFDPVEIAQAYEKGGAACLSVLTDQKYFQGGFENLEAIRSAGVKCPLLCKEFVVDPWQIYYARTKGADAVLLIAAVLADLEITFLLKICKKLSLAALVEVHDEREMGRVLGIEGIELVGINNRSLETFEVDISNTKKLLEGEHGRQIRERDMIVVGESGLFTPDDIAYVQAAGVKAVLVGESIVKQNDPEKGIAGLFGRNISHT
What is the function of this protein?
Indole-3-glycerol phosphate synthase required for tryptophan biosynthesis.
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, chloroplastic, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LPXH_HAEDU
Sequence: MMTYYFIADLHLNESQPQITHQFLQFMQQKAPLAQAVYILGDFFDFWIGDDEQSVLISQVKLALKKLTASGVKCYFICGNRDFLLGQTFAQQTGIQLLADYHLLDLFGERTLLCHGDTLCIDDIKYQQFRRRVHQKRLQKLFLWLPLTLRIKIAQKIRRKSKQDKKNKSADIMDVNQAFTAQKVHQYGATHLIHGHTHRQAVHFEQNFTRIVLGDWRPDRSSILKVDEKGFEFL
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YGN3_SCHPO
Sequence: MGKFALNLNAELTGVKNLAPKDEESFYYAFKVQCSGCREIHDNAIEISRSETHSIPGSKGEANLIWTCKNCRKTCSFVIEGPFSPYNDSQETKKVLVLECRGCELVEFIPQGEWIANGAESNTLFDEIVLEDDWYDYDENASSEVSITNLEWSISKA
What are the official names of this protein?
UPF0587 protein C2D10.03c.
What is the protein family that this protein belongs to?
Belongs to the UPF0587 family.