Protein: MILA_CORMM
Sequence: MEPIAIVGSACRFPGDATSPSKLWELLKAPRDLSQEVKRFNAKGFYHENGHHHGASNVMAAYTLESDPMEFDPQFFNIQPGEAESMDPQHRLLLETTYEGLEQAGIPIESLRGSDTSAFIGVMSADYTTMVFFDSECTPTYSATGTSRAILSNRLSHAFDWRGASMTLDTACSSSLVAIHLAVRELRSGSSRVAVAGGTNLILSADPFISETNLDMLSPQGKCHMWDARANGYARGEGISVVVLKTLRDALADGDHIECIIRETGVNQDGHTPGITMPNPEAQTRLIRDVYSRAGLDLSKPEDRCQYFEAHGTGTKAGDKVESRAIHDAFFPETGGEQAPLEPLYVGSVKTIIGHTEGTAGVAGVLRASLAIQNGTIPPNLHFESLNPELKPYYGNLQIATEAIPWPELHGGVRRASVNSFGFGGANCHVILEGYLPSYGDDALREVVSKPSLSSSPSLSPTSTSPPTPRTPANSLPFLISASSEKTLRKLVQRYIDHVGQNPNVDMGNLAWTLFKNRSALNFRLAVPAPTPEALITTLESVLKQPAGGPKSSIIRTVSQPKRLLGVFTGQGAQWATMGRQLVQKSARAAATVDRLDAALAALPDPYRPTWSLKAQILAEKKASRIDESAVSQPLCTVIQIILVDLLRNAGVDFDGVLGHSSGEIAAAYAAGFLSAEDAVKIAYTRGLCAHLARGQQGEKGGMIAAGMTHPDAKDLCENEAVLGRISVAAYNSPTSVTLSGDSDVIDQVSVVLEDEDKFNRVLRVQTAYHSHHMEACVGLYRKALAACNITVLNPAQHVPWFSSVYGGSVMSATSNIASEYWIQNMVQPVLFSEAVAAASQTEHQDALPTLAEIGPHPALKSPVLETLKSLGIDKVAYCGTLSRAVDDVDALSAFFGWFWSVSAQSGLQLDRYAAQFSQNKLVSLRNLPSYPWDHTHSYEFESRESHAHRFRELPCHPLLGVRTNTCGDAEYRWKNFLSTEEIPWLTGHQIQGQTLVPAAMFLIMAAEAATIAAGSLGLQVRLIELHDSTIHRALALDDDKSTETLFYLSGVEVTSSPNEGSILSATYHCDAATSKSSSRLTSIASGKVQLFVGGDASRTLPNSALGSGQLNEIDVDTFYDNLRTIGYNYNGAFRSIASLQRTTNWANGTIAAPTSTDPATSPSWVPLHPAVLDVSFQAVFAALSYPGDGRLQTLHVPTTIKRLTISPAALSSGAIPAGGFAFNAVSYMLDRRTICGDIEVGIAGQEESIFKVEGLTVSPVAPVTADDDKHMFADMVLCVAEPSTALLPDVPEQLLANTLSQNYGEAENAVSNKHSSLENGHLTNGHCLANGGHSTNGLTNGHASTNGHGSTNGHISTNGHSTNGDVLTNGHSVNGHAHSNGHSENGAISVNKPTAGGYTADKARSYHIVAGLLKQITDRYPKARILERVTDNASEVLNVFTAIGGRLSSYALDGIAESEFDAIADSRDDGSSLKRVSLQLESPSFLETNAGGEYDVVVLRDGHATDKGTLQLLRHLLRPGGYLLLIHELDQSLASLEGDSELWSGRFTEAGFSKMEAQGSSKSGRFSIMATMATNDAVDALRQPMVSVGAKIPTLIIIGGETPVTVDLIGKIRALLAPFCQVVQTVKSLAHLDDSAVAEKAFVLSLTELDSDLYRDLSEKTFTKLQELTTRSDRLIWVVSGSQGRNPYANMIKGTLRCLIEECSHLVTQILDIEDNVSGAGQFISDAVLRLHNLHSMENASKTLWSHEPELHLRNGQPFISRYLPNKQLDLGYNSLQRHVQVELQPTAGVLQLSADKSALSLERLRVAALPSSHLAANELETEIIVRYSQSVAVHVPALGYLYPVTGTDVQTGRVVAALSTENRSRVSVHKATLVPLIGLSDDQERSLPERLQAFFLAATIMQRCPPFTSAVVHEASNSLTQLLVDAGRKSGVQFIFTTSDASRVDEIQEQGWKFIARHGSTRQLSKLVQPDTLMCVDCTQTGSGDSLAAMGLQVPSGVAVLTASDFVRPQSFKYRKIEDQAVHEALKAAVAETTSLAAEKSDLGADGMIQIQDLPQSFAFGVPAKTISWVNELPVRATVLPALEECHFNPDRTYFLVGMAGSLGLSTVSYMISRGARHFALSSRNPQVDAAWIAAQRTKYGAVVNTFALDITDKAALTKTIAAIRATMPPIGGVANGALIIEDSLFADLTYKQMTRALGPKVDGSRYLDEAFGQDDLEFFILYSSLVSIAGNTGQIAYAVANSFMVSLAHQRRQRGLAASVINLTGVSGIGFITRTGHNIIARSKALGYDIISESDYCYIFAESVLASPSTSPHGPEVSSSLRYVDVARDKVVPPWAYDAKFGHYLLDRQAPATNGAAGESDNGGHLSLDVLKAAPPAECYDMIFRAFQTVLQKLLRLPADQPVPAEVQILDLGVDSLVAVKMRQWFLKELQVNMPVMKLIGGATVSQVVWSVVHQILPESAK
What is the function of this protein?
Highly reducing polyketide synthase (HR-PKS); part of the gene cluster that mediates the biosynthesis of cordypyrones A and B, 2 pyrones that show modest activities against pathogenic bacteria including methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium tuberculosis and Bacillus cereus (PubMed:34548637).  The HR-PKS milA catalyzes the formation of cordypyrones A via condensation of one acetate with 10 malonate units (PubMed:34548637).  Since milA lacks an enoyl reductase domain, the 2 beta-keto processing domains DH and KR of milA collaborate with the trans-enoyl reductase milB to catalyze the different levels of reduction (PubMed:34548637).  The cytochrome P450 monooxygenase milC then hydroxylates the C-22 of cordypyrones A to yield cordypyrones B (PubMed:34548637).
What are the official names of this protein?
Highly reducing polyketide synthase milA, HR-PKS milA, Cordypyrones biosynthesis cluster protein A.