PharMolix/UniProtQA huggingface dataset:
Protein: Y791_CHLMU
Sequence: MYFTRDPVIETVITSREGYKLSIRNSKHLSQDPFVVEAVEVIRLGGTSFFRNCDHSKPFLVPAADYEVMEVRDAKINLKAVGLDRGVKIVSGREALLKMPRVAPVASVQEESSSSLEEGIIEDPVVATPSPASAAPMSKKEKRKEFKNEKWKEKKKQGRRRNSKEIADAVGSSQDMIDTITEECLQESSPEERDPCERRFALIPPPTRLISEGPEEPKESQPVTAVDLNESLNALVSESCDVIESILADEDTVIFTKESEKSSNETQELSSHSLEEASVHDRISSEE
What are the official names of this protein?
Uncharacterized protein TC_0791.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0623/CT_504/TC_0791 family.
Protein: YIDD_STRA5
Sequence: MLKSFLIFLVRFYQKNISPAFPASCRYRPTCSTYMIEAIQKHGLKGVLMGIARILRCHPLAHGGNDPVPDHFSLRRNKTDISD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YO11_BPL2
Sequence: MKKLINQFIYIDENNPRVLMEPGIFIAVKLINLFIQTYISNAKITYSNDELIGKMGCSRSGLYDAFRVLEREGLIKRIYSDTKKRNRTEIEFNIDLAASWLKLTIYDKAYKNAPKRSLLRAVVSQTMIIIKDTKERILEAVGVRKSKDRKQRIEQIVKETERNYNRYVKHLKQRKIKQDKINATRKESILRHHLILGSIDWIKSLGMEPNPPDTLKIA
What are the official names of this protein?
Uncharacterized 25.6 kDa protein, ORF11.
Protein: SYL_BLOPB
Sequence: MRKSYSPSDIESVVQKHWYKNKTFAVIEDSNKEKYYCLSMIPYPSGNLHMGHVRNYTIGDVISRYQRMLGKNVLQPIGWDAFGLPAEHAAIKNNTDPSIWTYSNINYMKSQLQSLGFAYDWNRELITCHPDYYRWEQWFFTVLYKKGLVYKKTASVNWCSYHKTVLANEQVTNNCCWRCHTPVKYKRIPQWFIRITNYADQLLHGLDQLTHWPEQVKIMQRNWIGRSKGVNVTFRIENSNDTLTIYMTRLDIFMGITYLVISTDHPIALQVAKTDLNVAHFIQKNDDFYTKLNKKNVFYFEKMGMPTHIYAIHPITNSKLPIWVANFVIPMECDGMGAAISIPAHNQQDWEFAYKYNLPIKPVIKNLDAIEPNIAMQAQETTCDGILFNSGEFDGLSSCTASNAIVKSLIARGVAQYKVNYRLKDWGISRQRYWGVPIPMVTLSNGVVKPVLLDRLPVILPKNMSTIHRSNDGYVDNSLKMYPNWIQTTYKGQAAIRDTDTFDTFMESSWYYARYTCPRYNDAMLNVHAANYWLPVDQYIGGIEHAIMHLLYFRFYHKLMRDEGLVYSDEPAIRLLCQGMVLADSFYYVSPNGQHIWVDPTHVTIKRDRIGGIVKAIDKDGRDLIYDGMCKMSKSKNNGIDPNIIIEKYGADAVRFFIMFAAPIEAPLEWKESGIEGAQRFLKRIWNLIYHHIQDGPVDALSVVILNHAQKFIRYNVHKTIEKVTDDIDRRQSFNTALSAIMKLVKKLYNAPKTSMQDRAVLQEALLVIVRLLYPFTPHISFILWKALGGSEDIDNATWPIVDTQAIQNDRTLVLVQINGKMRHKVFAPLNSDKNVVYKLLETEGVLNKYLIGKKINNIIYVPNRVINIIAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRP54_MYCGE
Sequence: MFKAMLSSIVMRTMQKKINAQTITEKDVELVLKEIRIALLDADVNLLVVKNFIKAIRDKTVGQTIEPGQDLQKSLLKTIKTELINILSQPNQELNEKRPLKIMMVGLQGSGKTTTCGKLAYWLEKKYKQKTMLVGLDIYRPAAIEQLETLSQQTNSVFFAQGTQPVAKTTKAALSAFKTAKCQTIICDTAGRLQTNETLMDELVSVKNELNPDEIIMVVDGLSGQEIINVAQTFHKRLKLTGFIISKLDSDARAGAALSLASLLQVPIKLIGVSEKLDGLEQFHPERIANRILGLGDVMSLVEKAEQVFDKKDLTKTISKMFLGKMDLEDLLIYMQQMHKMGSVSSLIKMLPANFSVSEENAELIENKIELWKVLINSMTREERRHPKLINRDPNRKQRIIKGSGRKMDELNKLMKEWNKMQLKATEMGKLLKTGSNPFGGFGQFF
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle protein, Fifty-four homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: TILS_BURMA
Sequence: MIPPHEFSAERVVFDALGVALSALPDDTPIAIAYSGGLDSTVLLHAAARIAGAGRCIALHVHHGLSANADAWLAHCAETAQALGARFDAARVDVPRASGQGIEASARDARYRALETMCARYGARTLWLAQHADDQAETVLLQLLRGAGIAGLAAMAPQYRPALADVVRMRPLLHLLRAQLERYAQQHALRWIDDESNTDTRYARNALRVDVLPALAPHFPGFRDALARTAQHAAAAQRLLDDLAAIDLRAVARADVRVLSRDAFVALDDERGANLLRYWMRSLGLPGASAARLAEMVKQLRAARDAHALRVDHAGWRLRLYRDDVQWEAGDGAASEAARADVADDDAADARDDRADASAAARLPACALAWRGHEVWRLPGWRGSFVFSPVAAHEHDAVPEALLSSAALRACARAGGERMRTWQGGPGRTLKNLFQERGVPAWQRDVPLLYVGERLLFVPRIGVNRATHDGADAPGGWRRIEWRPDMLIA
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_BURPS
Sequence: MMNAEAKPGDWLGKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALAKTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRRSCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCA17_HUMAN
Sequence: MGPTRKPNVCSRLSRRALGCFSRDAGVVQRTNLGILRALVCQESTKFKNVWTTHSRSPIAYERGRIYFDNYRRCVSSVASEPRKLYEMPKCSKSEKIEDALLWECPVGDILPNSSDYKSSLIALTAHNWLLRISATTGKILEKIYLAPYCKFRYLSWDTPQEVIAVKSAQNRGSAVARQAGIQQHVLLYLAVFRVLPFSLVGILEINKKIFGNVTDATLSHGILIVMYSSGLVRLYSFQTIAEQFMQQKLDLGCACRWGGTTGTVGEAPFGIPCNIKITDMPPLLFEVSSLENAFQIGGHPWHYIVTPNKKKQKGVFHICALKDNSLAKNGIQEMDCCSLESDWIYFHPDASGRIIHVGPNQVKVLKLTEIENNSSQHQISEDFVILANRENHKNENVLTVTASGRVVKKSFNLLDDDPEQETFKIVDYEDELDLLSVVAVTQIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQKPNRVFSCYVYQMICDTGEEEETINRSC
What is the function of this protein?
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
What are the official names of this protein?
DDB1- and CUL4-associated factor 17.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Nucleus, nucleolus. Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.
Protein: GAG_JEMBR
Sequence: MKLSKLEKALKKVRVTPQRDDTYTIGNVLWAIRMCRLMGLDCCIDEATAAEVAILIGRFQSLDLQDSPLKGKDEKAILTTLKVLWSLLAGHHPENSDMAEKYWEAWTIRERESQKEEEGEITSIYPQLRKNFPAVSTSDGSPRYDPDLTKQLKIWADATEKHGVDHHAVNILGVITANLTQSEIRLLLQSTPQWRLDIQLIESKLNAREHAHRVWKESHPEAPKTDEIIGKGLTAAEQATLTTQECRDTYRQWVLEAALEVAQGKHDRPGPINIHQGPKEPYPEFVNKLVTALEGMAAPETTKQYLLDHLSVDHANEDCRAVLLPLGPSAPMERKLEACRAVGSSKQKMQFLAEAFAAINVKGDGEVQRCYGCGKPGHIRRDCKNQKCFKCGKPGHLQRNCKSKNGRRSSAPSGQRSGYHQEKTSVTPSAPPLVLD
What is the function of this protein?
Nucleocapsid protein p13 encapsulates and protects viral dimeric unspliced (genomic) RNA.  Binds these RNAs through its zinc fingers (By similarity).
What are the official names of this protein?
Gag polyprotein, Pr53Gag.
What is the protein family that this protein belongs to?
Belongs to the bovine lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Matrix protein p16]: Virion. SUBCELLULAR LOCATION: [Capsid protein p26]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p13]: Virion.
Protein: EFP_CLOB6
Sequence: MISAGDLRKGTTFEQDGQVYVVVEFLHVKPGKGAAFVRTKLKNAITGAVTETTFNPTAKLQEAVIERKEMQYLYTDGELYYFMDQETFEQIPLNYDKVEEAIKFLKENMFATIKFFKGEAFSVEAPNFVELLISHTEPGAKGNTTSNVMKPATLETGATIQVPLFVNEGETIRVDTRTGEYMERV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_SALCH
Sequence: MSIILGIDPGSRITGYGVIRQVGRQLTYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQVRGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNVMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: BDNF_BOVIN
Sequence: MTILFLTMVISYFGCMKAAPMKEANLRAQGSLAYPGVRTHGTLESMNGPKVGSRGLTSSSSLADTFEHVIEELLDEDQKVRPSEENNKDADMYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
What is the function of this protein?
Important signaling molecule that activates signaling cascades downstream of NTRK2.  Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2.  Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD).  Binding to NGFR and SORCS2 promotes neuronal apoptosis.  Promotes neuronal growth cone collapse.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted. SUBCELLULAR LOCATION: [BDNF precursor form]: Secreted. Note=A proportion of BDNF is secreted as immature precursor (proBDNF).
Protein: U85C1_STERE
Sequence: MDQMAKIDEKKPHVVFIPFPAQSHIKCMLKLARILHQKGLYITFINTDTNHERLVASGGTQWLENAPGFWFKTVPDGFGSAKDDGVKPTDALRELMDYLKTNFFDLFLDLVLKLEVPATCIICDGCMTFANTIRAAEKLNIPVILFWTMAACGFMAFYQAKVLKEKEIVPVKDETYLTNGYLDMEIDWIPGMKRIRLRDLPEFILATKQNYFAFEFLFETAQLADKVSHMIIHTFEELEASLVSEIKSIFPNVYTIGPLQLLLNKITQKETNNDSYSLWKEEPECVEWLNSKEPNSVVYVNFGSLAVMSLQDLVEFGWGLVNSNHYFLWIIRANLIDGKPAVMPQELKEAMNEKGFVGSWCSQEEVLNHPAVGGFLTHCGWGSIIESLSAGVPMLGWPSIGDQRANCRQMCKEWEVGMEIGKNVKRDEVEKLVRMLMEGLEGERMRKKALEWKKSATLATCCNGSSSLDVEKLANEIKKLSRN
What is the function of this protein?
May glycosylate diterpenes or flavonols in leaves.
What are the official names of this protein?
UDP-glycosyltransferase 85C1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: VA1_BPBF2
Sequence: MIFYPTESLILGLFIMAASLLFAYFQNDLDSYYFKRK
What is the function of this protein?
Proteins A1 and A2-A3 are necessary for completion of phage DNA transfer.  A1 is also required for the shut-off of expression of pre-early genes.
What are the official names of this protein?
Probable protein A1.
Protein: IZUM1_HUMAN
Sequence: MGPHFTLLCAALAGCLLPAEGCVICDPSVVLALKSLEKDYLPGHLDAKHHKAMMERVENAVKDFQELSLNEDAYMGVVDEATLQKGSWSLLKDLKRITDSDVKGDLFVKELFWMLHLQKETFATYVARFQKEAYCPNKCGVMLQTLIWCKNCKKEVHACRKSYDCGERNVEVPQMEDMILDCELNWHQASEGLTDYSFYRVWGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLPKMIKEEKPSPNIVTPGEATTESSISLQPLQPEKMLASRLLGLLICGSLALITGLTFAIFRRRKVIDFIKSSLFGLGSGAAEQTQVPKEKATDSRQQ
What is the function of this protein?
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg.  The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion.  The ligand-receptor interaction probably does not act as a membrane 'fusogen'.  Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization (PubMed:36070373).  FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion (PubMed:36070373).
What are the official names of this protein?
Izumo sperm-egg fusion protein 1, Oocyte binding/fusion factor, OBF, Sperm-specific protein izumo.
What is the protein family that this protein belongs to?
Belongs to the Izumo family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes) (By similarity). During the acrosome reaction, translocates to the plasma membrane (PubMed:15759005).
Protein: PSBZ_CITSI
Sequence: MTIAFQLAVFALIATSSILLISVPVVFASPDGWSSNKNVVFSGTSLWIGLVFLVGILNSLIS
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: S35D2_PIG
Sequence: KGEAPAKSSTHRHDEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQMVATVAVLWVGKALRVVKFPDFDRNVPRKTFPLPLLYFGNQITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKTFSWGIKMTVFAMIIGAFVAASSDLAFDLEGYVFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYITGDAQKAMDFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIGMVFGGDYIFTWTNFIGLNISIAGSLVYSYITFSEEQLSKQSEASNKLDNKGKGAV
What is the function of this protein?
Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars).  May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter, Solute carrier family 35 member D2.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: DB118_HUMAN
Sequence: MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCIPSNEDHRRVPATSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDMVEESEAGRGTETSLPNVHHSS
What is the function of this protein?
Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E. coli and S. typhimurium, and Gram-positive bacteria, such as S. aureus and B. subtilis (PubMed:15033915, PubMed:33224970).  Inhibits cell adhesion of E. coli on intestinal epithelial enterocytes (PubMed:33224970).  Causes rapid permeabilization of both the outer and inner membrane of E. coli, leading to morphological alterations on the bacterial surface (PubMed:15033915).  Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (PubMed:33181266).  May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (PubMed:15033915).
What are the official names of this protein?
Defensin beta 118, Beta-defensin 18, DEFB-18, Epididymal secretory protein 13.6, ESP13.6.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: VFA1_YEAST
Sequence: MINEYVARKVALKDMQPCAICSKPSTTVLYNASGPDWLYTCEIHLQDNPQFVIPLYSTEYNEAVAQLKLVKGKMDSLTSAQTQLGSWDGWVTKIFSKKEKETNNSKDPDPTTTDSTDTSPQAKNDAEILSETKKQYSKILDKVTELQRKNRKYELAKIMFESRLLRKRTEQVNRERYLKEQENYSNTDPEELLRKHVFPSVPK
What is the function of this protein?
VPS4-associated protein involved in trafficking to the vacuole.
What are the official names of this protein?
VPS4-associated protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Endosome. Note=Requires VPS4 for its recruitment to endosomes.
Protein: GYRB_ACIHA
Sequence: DNSYKVSGGLHGVGVSVVNALSSKLQLTIHRAGQEHQQEYHHGDPQYPLRVIGETDRTGTIVRFWPSAETFSQTIFNVDILARRLRELSFLNAGVRIVLRDERVNLENVYDYEGGLSEFVRYINEGKTHLNEIFHFTTDADNGISVEVALQWNDSYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNSYMENENLLKKEKVVVSGDDAREGLTAIISVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKEFSAYLLENPQAAKSIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_GEOSM
Sequence: MAKLDVFDIKKAKVGEIELDDAVFNDDVREYLIHEAVKIQLANRRQGTVAVKNRALVAGSGKKPFKQKGTGQARQGCRRAPQYPGGGVAFGPQPKDYNLSMNKKARKAALRSALSMLYKKDAITVVNSLELPSIKTKAFVEVLTAFNLDKTLVITDTATPTLELSARNVKHVKVLGPEGLNIFDIMKYQSVVFTEAAVRRVEGALQS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PYRB_WOLPP
Sequence: MDKRRNLLNISDLTIGDVENITKLANQYLEEKVENSHVLKNKIVINLFFEDSTRTLASFEIAAKSLGANVITLPIKSSSINKGEDLKDMIKTLNAMNPDYMIIRHKSSGIINTLAKHVNCSLINAGDGSSEHPTQALADYLVIISHKKQIKNLKIVICGDILHSRVARSNIRLLKMFGAKISLVAPPALMCKHFSEVDSLHYSLTEGIKDADVIMLLRLQKERMNNNSSEKEYFHLYGLDAQKLSHAKPDAIVMHPGPINRGIEISNDIADCVILQQVKFGLATRKAVLHYLINV
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: MTNA_CERSK
Sequence: MKINGTPFRSIWCEAGEVRIIDQRWLPHELRIVPLRTRAEFAAAIRDMWVRGAPLIGATAAWGMAVQMAEDPSDASLAETWQVLHETRPTAINLRWALNEMRRLLAPLPPSERAAAAARRAAEICDEDVEINRRIGAHGLTLIREIAERKRGRVNILTHCNAGWLATVDWGTATSPIYHALEAGIDVHVFVDETRPRNQGALLTAWEMNSHGVSHDLIVDNAGGHLMQHGEVDLVIVGTDRTTAQGDVCNKIGTYLKALAAKANGVPFYVALPSPTIDWTVRDGVAEIPIEERSSAEVTHVQGKAPDGSVISVQISPDGTGARNPAFDVTPASLVTGLITERGICAAEAGAMEALFPEAARSAA
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: SYT_STRP7
Sequence: MINITFPDGAVREFESGVTTFEIAQSISNSLAKKALAGKFNGKLIDTTRAITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGFYYDTDNTAGQISNEDLPRIEEEMQKIVKENFPSIREEVTKDEAREIFKNDPYKLELIEEHSEDEGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLHVAGAYWRGNSDNAMMQRIYGTAWFDKKDLKNYLQMREEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRELERYIVNKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPTMDMGDGEEFVLRPMNCPHHIQVFKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHLFVTPEQIQEEFQRALQLIIDVYEDFNLTDYRFRLSLRDPQDTHKYFDNDEMWENAQTMLRAALDEMGVDYFEAEGEAAFYGPKLDIQIKTALGKEETLSTIQLDFLLPERFDLKYIGADGEDHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVDYAWEVAKKLRDRGVRADVDERNEKMQFKIRASQTSKIPYQLIVGDKEMEDETVNVRRYGQKETQTVSVDNFVQAILADIANKSRVEK
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLVS2_MOUSE
Sequence: MTHLQAGLSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLLAQYFEYRQQNLDMFKSFKATDPGIKQALKDGFPGGLANLDHYGRKILVLFAANWDQSRYTLVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPNMLRLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLIHPEILPSEFGGMLPPYDMGTWARTLLDHEYDDDSEYNVDSYNMPVKDVDKELSPKSMKRSQSVVDPTALKRMDKSEEENMQPLLALD
What is the function of this protein?
Required for normal morphology of late endosomes and/or lysosomes in neurons.  Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).
What are the official names of this protein?
Clavesin-2, Retinaldehyde-binding protein 1-like 2.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle.
Protein: DIM1C_ARATH
Sequence: MMNAVITSATINCNSLSPSWTCGDNSPSKLLLGEISAALSRRRTVKVSCGKSSPDDYHSTLKSLNSRGRFPRKSLGQHYMLNSDINDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHIRSHMLSILETRRLSHPDSALAKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLVEPALRTSEYRPINILINFYSEPEYNFRVPRENFFPQPKVDAAVVTFKLKHPRDYPDVSSTKNFFSLVNSAFNGKRKMLRKSLQHISSSPDIEKALGVAGLPATSRPEELTLDDFVKLHNVIARE
What is the function of this protein?
Required for methylation of the 3' adenosines in the small subunit of plastid rRNA.  Essential for chloroplast biogenesis at low temperatures.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase, chloroplastic, Dimethyladenosine transferase 1C, Protein PALEFACE 1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CEMA_OLIPU
Sequence: MAKKKAFIPFFYFTSIVFLPWLISLCCNKSLKTWITNWWNTRQCETFLNDIQEKSVLEKFIQLEELFQLDEMIKEYPETDLQQFRLGIHKETIQFIKIHNEYRIHTILHFSTNLISFVILSGYSFWGKEKLFILNSWVQEFLYNLSDTIKAFSILLLTDLCIGFHSPHGWELMIGYIYKDFGFAHYEQILSGLVSTFPVILDTIFKYWIFRYLNRVSPSLVVIYHAIND
What is the function of this protein?
May be involved in proton extrusion.  Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
What are the official names of this protein?
Chloroplast envelope membrane protein.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.