PharMolix/UniProtQA huggingface dataset:
Protein: CD6_HUMAN
Sequence: MWLFFGITGLLTAALSGHPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESRELMLLIPSIVLGILLLGSLIFIAFILLRIKGKYALPVMVNHQHLPTTIPAGSNSYQPVPITIPKEVFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYNSQRHRVTDEEVQQSRFQMPPLEEGLEELHASHIPTANPGHCITDPPSLGPQYHPRSNSESSTSSGEDYCNSPKSKLPPWNPQVFSSERSSFLEQPPNLELAGTQPAFSAGPPADDSSSTSSGEWYQNFQPPPQPPSEEQFGCPGSPSPQPDSTDNDDYDDISAA
What is the function of this protein?
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089).  Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089).  Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752).  Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806).  Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria.  Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777).  LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777).  Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
What are the official names of this protein?
T-cell differentiation antigen CD6, T12, TP120.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938). SUBCELLULAR LOCATION: [Soluble CD6]: Secreted. Note=The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain.
Protein: LUXS_BACC4
Sequence: MPSVESFELDHTIVKAPYVRHCGVHNVGSDGIVNKFDIRFCQPNKQAMKPDVIHTLEHLLAFNLRKYIDRYPHFDIIDISPMGCQTGYYLVVSGTPTVREIIDLLELTLKDAVQITEIPAANETQCGQAKLHDLEGAQRLMNFWLSQDKDELEKVFG
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: OCA5_YEAS1
Sequence: MHDKKSPMANSHYLKNLKQQFRNKNLIETTIHLVKCNDHDSLAFLARTYGVPPQLRHVVWPILLKYHPMCISPNITSNTISWDPITNDFILNDPFLKSKAPTDKQDKSDDENILPYDIESIILHDLKKYFHSRSNPAGSSSNANTTNIATPTPVSSSDASTISSMEVLSPSLDYEFQIIETLKNAIVKFLLKWSKIFKYESGLAWIALGLAEWYPIYPYETMSPFNETHSFYEVEDYVVLSGRKHALLSTNNGNNGNSNSSSNNTNNNNTNITSGMHNLSINTNTSLHNSPYISHTLSYLYKEYPLPFELRSKLPTKPIFSFSALFERLALVILHCPDTILAHKQLKNDSNASSSSKANSNFNTNYFPIISGGDLSFQTQVFFKVFSSILPELYQPLTEESSLQPSSSRNSWIYWWLKCSGAKALQRQDRGRVWDLLLGWRPKPNMDTINFFLNYNDKKMDHLYHDTPQCDNEQYWMKDWIALYNNDPFWFPDLDSMALGSKKFPYDYSVFKELILRNRYGGTQSKAQKDNTVPSPGSDSNDKSELKLPFSSIDPHMQLIFIFIAILQFNEFKLLEFEEAEISEFLNNVPLLTKFDDSSYRKLYENTESSITSLPSSPTTSTMASLQSSSNSSAHISNYHMLIEVGNDAKASHCFDDLLNMAGDIWRKWLWRELEESSL
What is the function of this protein?
Required for replication of brome mosaic virus (BMV), a positive-strand RNA virus.
What are the official names of this protein?
Oxidant-induced cell-cycle arrest protein 5.
What is the protein family that this protein belongs to?
Belongs to the OCA5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_RHIL3
Sequence: MTIHHDLSPTLNLIRLANGEGLDLPAYESKGAAGMDLRAAVDEAAPLTLLPGKRALVPTGFIFEIPEGFEGQVRPRSGLAFKNGITCLNSPGTVDSDYRGEVKVLLANLGEEAFVISRGMRIAQMVIAPVTQMRVAEITEASETMRGAGGFGSTGV
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: TBB2_ERYPI
Sequence: MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEACDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYEICMRTLKLSNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMYDPKNMMAASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSAYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVHEYQQYQDASISEGEEEYEEEQQLENEE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-2 chain, Beta-2-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: CHI_ARATH
Sequence: MAKPTSRNDRFALFFITLIFLILTVSKPVASQNCGCASDFCCSKYGYCGTTDEFCGEGCQAGPCRSSGGGGDPAVSLEGTVTPDFFNSILNQRGDCPGKGFYTHDTFMAAANSYPSFGASISKREIAAFFAHVAQETGFMCYIEEIDGPAKAASGEYCDTEKPEFPCAQGKGYYGRGAIQLSWNYNYGLCGKALDENLLASPEKVAQDQVLAFKTAFWFWTTNVRTSFKSGFGATIRAVNSRECSGGDSTAKAANRIKYFQDYCGKLGVAPGDNLTC
What are the official names of this protein?
Endochitinase CHI.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: RSMA_AGRFC
Sequence: MAAIDGLPPLRDVIQRHGLDAKKSLGQNFLFDLNLTQKIARTAGPLDGVTVIEVGPGPGGLTRAILSLGAKKVIAVERDSRCLPVLAEIEAHYPGRLEVIEGDALKTDFEALVPAGEPVRIIANLPYNVGTQLLVNWLLPREWPPFWLSMTLMFQKEVGQRIVAEEGDNHYGRLGVLAGWRTVSEMAFDVPPQAFSPPPKVTSTVVHLLPKDKPLPCDVAKLERVTEAAFGQRRKMLRQSVKSLGGETLLEKAGIDPTRRAETLSVEEFVTLANCL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_RHOPS
Sequence: MTTVPIDNIRNFSIVAHIDHGKSTLADRLIQITGGMSDREMAGKEQVLDSMDIERERGITIKAQTVRLNYRAKDGKDYIFNLMDTPGHVDFAYEVSRSLAACEGSLLVVDASQGVEAQTLANVYHALDAGHEIVPVLNKVDLPAAEPDKVKQQIEDVIGLDASDAVMISAKTGLGVPDVLEAIVTRLPPPKGDRGATLKALLVDSWYDVYLGVVVLVRVVDGVMKKGQRIRMMGTGAAYDVERVGFFTPKMTAVDELGPGEIGFITAAIKEVADTRVGDTITDDRKPITEMLPGFKPAIPVVFCGLFPVDADDFETLRAAMGKLRLNDASFSFEMETSAALGFGFRCGFLGLLHLEIIQERLSREFDLNLIATAPSVIYKMKLNDGSEIEIHNPVDMPDVVKIAEIEEPWIEATILTPDEYLGSVLKLCQDRRGNQKELTYVGARAMVKYDLPLNEVVFDFYDRLKSVSKGYASFDYHLTDYKPADLVKMQILVNAEPVDALSMLVHRTRAEGRGRAMVEKMKELIPPHMFVIPIQAAIGGKIIARETVRALRKDVTAKCYGGDITRKRKLLEKQKEGKKKMRQFGKVDIPQEAFIAALKVDS
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYY_PHYMT
Sequence: MSLFEELKWRNLITECSDEKRAKLLLDGNKKIKFYCGFDATAGSLTVGHLVQIITFLLIQKKGHFPIVLLGGATSFIGDPKKIEERKLLDPSQILDNFNKISLQFKKILSFISFEIVNNYDWISKIDVINFLRKYGKLFNINYMLSKEVIANRLKKGLSYAEFSYMVLQSLDFQYLFEHKNVIMQFGGSDQWGNITSGLELIRKINKIKDNDKPVGMTNALLLKSDGTKFGKSEDGVLWLDQKLTSPYKIYQYFLNTEDKEVVNYLKSLTLLSKKEIINLKEENIVNPQKRLAQKILAKEIITLIHGKKIFENCFNTNQALFVGKKDQLSEQSFYFLKYTLNYIEVNDKISLLEALVFTKLTNSKNKAKELISNHAIKIFDQIVDDTELILNIKHSLFNKYILLKKGKRFNALIIFK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_GLAP5
Sequence: MQNLENIVAEALQAVEKASDVASLEALRVEYFGKKGHFTLLMQGLRDVPADERPAVGAKINEAKQKAQDALNGKKEQLETEELNAKLASESIDVSLPGRKTELGGLHPVSITIERVVKFFSELGFSVEKGPEIETDYYNFDALNIPAHHPARADHDTFWFDAERLLRTQTSGVQIRTMEKMQPPIRIMAPGRVYRNDYDQTHTPMFHQIELLYVDKKANFTELKGLLHDFLRAFFEEDLQVRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPDEYTGFAVGMGVERLTMLRYNVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RKGG_LEPKE
Sequence: SDDDGTVVLTTSGPIRGKRLQVGSAAVTAF
What is the function of this protein?
Rathke gland secretions may function as pheromones, as predator repellents, or contribute to the maintenance of the turtle shell.
What are the official names of this protein?
Rathke gland glycoprotein.
What are the subcellular locations of this protein?
Secreted.
Protein: NSP4_ROTH6
Sequence: MEKLTDLNYTLSVITLMNSTLHTILEDPGMAYFPYIASVLIVLFTLHKASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVVKEMRRQLEMIDKLTTREIEQVELLKRIYDRLMARSTDGIDMTKEINQKNVRTLEEWESGKNPYEPKEVTAAM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: LSPA_AZOSB
Sequence: MPDLQAGQRPAFVAMLPWLVLAAAVMGLDQLTKQVVLATMQYGEVIPVTGFFDLVLVFNRGAAFSFLAEHSGWQRWFFTGLAVVICGWLLALMHQHREERLLPAAFALIIGGAIGNVVDRLLHGAVVDFLYFHAGRYGWPAFNLADSAITLGVGLMLWAQLRAGKHKPEAGPERPS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDTIR_PARDP
Sequence: MSANDRAIETLRREIAKLQTDGAAIARKDAGIRAKLASAMAAQAKAKTAPALRLKQAEASRLEKELMATSKSQADIATKIAKKQSSLSAKLVVQANEAKKADAKAKKNQERVSKTQEEATRKLEAGYRKLTLENQSLEQRLQRELSAMKPTAGPTTNADLTSAPPHDIFISHAWEDKADFVEALAHTLRAAGAEVWYDDFSLRPGDSLRRSIDKGLGSSRFGIVVLSTHFFKKEWPQKELDGLFQLESSGRSRILPIWHKVSKDEVASFSPTMADKLAFNTSTKSVDEIVADLMAIIRD
What is the function of this protein?
NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide.
What are the official names of this protein?
NAD(+) hydrolase PdTIR, TIR domain-containing protein in P.denitrificans, PdTIR.
Protein: LBX2_MOUSE
Sequence: MNSVHQRRTPFSIADILGPSMVPEAPSAPQLPEAGPDPASPLCALEELASKTFLGHSPRATPQPSEGRAAPEAPPGPGAGVRRRRKSRTAFTAQQVLELERRFVFQKYLAPSERDGLAARLGLANAQVVTWFQNRRAKLKRDVEEMRADVASLCGLSPGVLCYPALPDSTSSPDPGPSGPDSEPNLSDEEIQVDD
What is the function of this protein?
Transcription factor.
What are the official names of this protein?
Transcription factor LBX2, Ladybird homeobox 2, Ladybird homeobox protein homolog 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS2_UREPA
Sequence: MSQMENSTKKVESVANVEVVTTENAKVEQKPTSPADAIQLKVNANSTIKNLKTLVSIVKLTESGAHIGLNPKKWNPKMASYIHAKRSNNHVIDILKTILFLDRAYKFLQEVSQNGGTVMFVGTRGRVVKELIKAEAERTNSFYVTQRWLGGTLTNFTNISRSLKKFNSNLALLESEEINKYSKKEQIAINKETAKLEKFYGGIKNMKQRPDVLILVDPVNDVNAIKEARKLNIPVIALANTNADPQLIDYIIPVNNYSVKSITLILGVLADSIAELHGEPTKIVGRPDSEIVLPETKSNWKQNNYDPSKRGYNPKYVNHKSTFNKFNNKKPVDSTTNEIKTNVIKAETK
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: NIFB_METIM
Sequence: MEKMSKFSHLLKAHPCFNEKVHDKYGRVHLPVAPRCNIACKFCKRSVSKECCEHRPGVSLGVLKPEDVEDYLKKILKEMPNIKVVGIAGPGDSLFNKETFETLKIIDEKFPNLIKCISTNGLLLSKYYKDLANLNVRTITVTVNAIKPEILEKIVDWVYYDKKLYRGLEGAKLLIEKQIEGIKKASEEDFIIKINTVLIPEINMDHVVEIAKFFKDYAYVQNIIPLIPQYKMKELRAPTCEEIKKVRKECEKYIPQFRACGQCRADAVGLIKEKELLKEFFKEKNKEKNIKLEVFDLKHFSH
What is the function of this protein?
Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms (PubMed:27268267).  NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster (PubMed:27268267, PubMed:26969410).
What are the official names of this protein?
FeMo cofactor biosynthesis protein NifB, Nitrogenase cofactor maturase NifB, Radical SAM assemblase NifB.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. NifB family.
Protein: SP110_MOUSE
Sequence: MFTLTKALEKALLQHFIYMKVNIAYAINKPFPFFEALRDNSFITERMYKESLEACQNLVPLSKVVHNILTSLEQTFHPSVLLTLFSKVNLREYPSLVAIFRSFRNVGYTYEEKNRPPLTLLEDLANPAEGCSLQTLLPPPRPQISLPSHLSSAPRVCDPRATAQPIIEILDEQPSPSPRAVPLLGCIQEGKTTPVSSRDHQRKDKEDSREMPHSPSGPESVVKDDSPAANDLEMAREVPCTPANKKARRKKRPNWSNSKRRRQKKKPRQDEMMGVASPGHGVQEKLKAVSRRTLWKDDSSTNVKEVTKTQRTRMRRAQTSNSQEISKEASKTSGRKRPSTARRTTQVPEKTKNDAVDFSPTLPVTCGKAKGTLFQEKLKQGASKKCIQNEAGDWLTVKEFLNEGGRATSKDWKGVIRCNGETLRHLEQKGLLFFTSKSKPQKKGA
What is the function of this protein?
May act as a transcription factor.  Plays a role in the innate immunity against intracellular pathogens.  Required for resistance to M. tuberculosis and L. monocytogenes.  Promotes apoptosis of infected cells.
What are the official names of this protein?
Sp110 nuclear body protein, Intracellular pathogen resistance protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: YACL_ECO24
Sequence: MDYEFLRDITGVVKVRMSMGHEVVGHWFNEEVKENLALLDEVEQAAHALKGSERSWQRAGHEYTLWMDGEEVMVRANQLEFAGDEMEEGMNYYDEESLSLCGVEDFLQVVAAYRNFVQQK
What are the official names of this protein?
UPF0231 protein YacL.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: VNBP_ICRSV
Sequence: MEPHDQSGSTTRQLDEIRDRRGSQIRSVRLLPWRPFTRFPVCPSGTSPYSRGTHSQPSYVRCQNCERARQWFRAHDGPRCLHQRPDYSRLQAPPDPFQHLNSFEPILLAALSVLRPLPRDIQITIISCACDYFHSVRCASSRYLGSSRSAVKRRAARLNYCYKCGHPLYLNKPHTCRPGRLCSASISERLALLREGPIRSLTENPINARAAHFLAHELLDPR
What is the function of this protein?
May act as a regulatory factor during viral transcription.
What are the official names of this protein?
23kDa protein, Putative 23 kDa nucleic acid binding protein.
Protein: GPMI_VESOH
Sequence: MKSKKQTKLLLILDGWGYSKTTKNNAIALANTSVWDRLNQTFPHSLIHTSGKDVGLPGKQMGNSEVGHLNLGAGRIVKQDFTRIYNELQNGDFFRNPILRNSLEYANDNNKAIHIMGLLSDGGVHSHEEQIHAMLEMTSRQGCKNVYLHIFTDGRDCAQKSAKKYIKKLESKMKELNTGEIVSLIGRYFSMDRDNRWSRIRYAYELIAKGKAKFLAKSALNAIELAYARGETDEFIQSTSIKAPTSIKKGDVLILMNYRADRARQITCAFTDEDFQGFSRGTFVPTQFVCLTEYKKDFNLPVAYPSSKLNNVLGKYLSNLGMTQLRIAETEKYAHVTFFLNGGIEQAFNGEERVLIPSPDVATYDLQPEMSAFELTDALVENIESQKYDLIICNFANTDMVGHSGKLDATIKAVEAVDTCLGIIYKAMFAIGGEMLITADHGNAEQMINPQTNEVHTAHTNNPVPLIFVSNRKADIMKPGKGALSDIAPTLLAMMDIEKPDEMTGNSLLTFK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RL28_ENTFA
Sequence: MAKVCYFTGRKTSSGNNRSHAMNSTKRTVKPNLQKVRVLIDGKPKKVWVSTRALKSGKIERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ARGB_CYTH3
Sequence: MQKLYIIKVGGNIIDNPEALTSFLKDFASLKENKILVHGGGKVATEISKGLGIEAQMVDGRRITDAETLKIVTMVYGGLINKNIVAKLQSNECNAIGLTGADANIMLSSKRPLKNGIDYGFVGDVKKVHPQPLIHLLSQGITPVVAPLTHDGNGTMLNTNADTVASELAVALCGAFAVNLVYCFELKGVLRDFEDKDSVISTINPDTYEELKSTGVINKGMIPKLDNSFNAINAGVSSVIICQAESLVELINENKTVGTKLVAN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_HERAR
Sequence: MAFNRRSKNITQGVSRSPNRSMYYAMGYEKADFDKPMVGIANGHSTITPCNSGLQKLADIAIKTIKDAGGNPQVFGTPTISDGMSMGTEGMKYSLISREVIADCIETAVNGQWMDGVLVIGGCDKNMPGGMIAMLRTNVPSIYVYGGTIKPGHWKGKDLTIVSAFEAVGEFTAGRMSQEDFDGIERNACPSSGSCGGMYTANTMSSSFEALGLALPYSSTMANPDDEKVGSAAESARVLIEAIKKDLKPRDIVTRKAIENAVAVIMATGGSTNAVLHFLAIAHAAEIDWTIDDFERMRKKVPVICDLKPSGKYVATDLHKAGGIPQVMKVLLDAGLLHGDCMTITGQTVAEALAHIPSVPSADQDVIHTIDKALYAQGHLAILKGNLSPEGCVAKITGLKNPVITGPARVFDDEYSAMDAIMANQIKAGDVLVMRYLGPKGGPGMPEMLAPTSALVGQGLGESVGLITDGRFSGGTWGMVVGHVSPEAFVGGTIGLVEEGDSVTIDARQLLIQLNVSEEEIARRRANWKQPAPRYTRGVLAKYAALASTASKGAVTG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: INSI1_MOUSE
Sequence: MPRLHDHVWNYPSAGAARPYSLPRGMIAAAACPQGPGVPEPEHAPRGQRAGTTGCSARPGSWHHDLVQRSLVLFSFGVVLALVLNLLQIQRNVTLFPDEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD
What is the function of this protein?
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:16100574).  Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity).  Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:16100574).  In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (By similarity).  Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity).  Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (By similarity).  Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (By similarity).
What are the official names of this protein?
Insulin-induced gene 1 protein, INSIG-1.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.