PharMolix/UniProtQA huggingface dataset:
Protein: PI42A_HUMAN
Sequence: MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
What is the function of this protein?
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:9367159, PubMed:23326584).  Has both ATP- and GTP-dependent kinase activities (PubMed:26774281).  May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242).  May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity).  Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240).  In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity).  Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439).  May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity).  Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439).  PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
What are the official names of this protein?
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, PIP5KIII, Phosphatidylinositol 5-Phosphate 4-Kinase, PI5P4Kalpha, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, PI(5)P 4-kinase type II alpha, PIP4KII-alpha, PtdIns(4)P-5-kinase B isoform, PtdIns(4)P-5-kinase C isoform, PtdIns(5)P-4-kinase isoform 2-alpha.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Lysosome. Cytoplasm. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B.
Protein: DBH_BACCA
Sequence: MNKTELINAVAETSGLSKKDATKAVDAVFDSITEALRKGDKVQLIGFGNFEVRERAARKGRNPQTGEEMEIPASKVPAFKPGKALKDAVK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU, DNA-binding protein II, HB.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RV167_CANAL
Sequence: MSFKGFKKGVLRAPQTMRQKFNMGEITQDAVYLDAERRFKEIEMETKKLSEESKKYFNAVNGMLDEQIDFAKAVAEIYKPISGRLSDPSATVPEDNPQGIEASESYQAVVKDLKDTLKPDLELIEKRIVEPAQELLKIIQAIRKMSVKRDHKQLDLDRHKRNLSKYESKKERTVKDEEKMFSAQAEVEIAQQEYDYYNDLLKNELPVLFQMQSDFIKPLFVSFYYMQLNIFYTLYTRMEELKIPYFDLSTDIVEAYTAKKGNIEEQTDAIGITHFKVGHAKSKLEATKRRHAAMNSPPPTGASSIASTGTGGELPAYSPGGYNQPYGDSKYQPPSSPATYQSPVVAATAQSPATYQSPVATGQPPSYLPQTPASAPPPQVGSGLPTCTALYDYTAQAQGDLTFPAGAVIEIIQRTEDANGWWTGKYNGQTGVFPGNYVQL
What is the function of this protein?
Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level.  Plays an important role in virulence.
What are the official names of this protein?
Regulator of cytoskeleton and endocytosis RVS167.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y551_GEOTN
Sequence: MSESLHALARQLEQAIRASQPFQQLKQAYEDVRRDETAYQMFANFRDIQLRLHEKQMRGAAILPDEIEQAQKAMALAQQNAKLARLMALEQQMSMTIAEVQQIAMKPLEELHRSLMEEK
What are the official names of this protein?
UPF0342 protein GTNG_0551.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: ELAV2_RAT
Sequence: METQLSNGPTCNNTANGPTTVNNNCSSPVDSGNTEDSKTNLIDNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA
What is the function of this protein?
RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity).  Seems to recognize a GAAA motif (By similarity).  Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity).
What are the official names of this protein?
ELAV-like protein 2, Hu-antigen B, HuB.
What is the protein family that this protein belongs to?
Belongs to the RRM elav family.
Protein: PTSS1_BOVIN
Sequence: MASCVGSRTLSKDDVNYKMHFRMINEQQVEDITIDFFYRPHTITLLSFTIVSLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADVMEYAVNCHVITWERIISHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLSWCRILFIGGITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVVLWLLCVAFTTFLCLYGMVWYAEHYGHREKTYSECEDGTYSPDISWPHGKGSKGSEDGPHKHPGNSESHSSRRRNRHSKSKVTNGVGKK
What is the function of this protein?
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity).  Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
What are the official names of this protein?
Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I.
What is the protein family that this protein belongs to?
Belongs to the phosphatidyl serine synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Protein: Y2355_STAA8
Sequence: MKDLTMLLDELKDMSFFNKGDICLIGCSTSEVIGEKIGTVGSMEVAETIFNALDVVSKETGVTFAFQGCEHINRAITIEKSQYNPLTMEEVSVVPDVHAGGSLATYAFQHMKDPIVVEHITVPCGIDIGQTLIGMHIKHVCVPVRTSVKQVGQAIVTIATSRPKKIGGERAKYQ
What are the official names of this protein?
UPF0340 protein SAOUHSC_02355.
What is the protein family that this protein belongs to?
Belongs to the UPF0340 family.
Protein: Y755_AQUAE
Sequence: MKLLAWSPVLLSSKKFPEENGKKFIPGSEIKEAIKDALVYYFLKKDKALNTKVKNYVKRHKRTSLRKFVREIEKMVFEAEKEFIESIEVPEKVYLSSEGIKEKVVEVYDLKRKDFKDYFKSEVFEGVAEFEVKANNYEKLRSACHSYAEALAHAELTLVRDHPIGEIFHKNLLSEMKNWEIPLRVGFWTTAPFGGRLFWFWGDKEIRNRIRRLYRLDIRPRSVIYVPSEKKTAGWTEVKKDA
What are the official names of this protein?
Uncharacterized protein aq_755.
Protein: TUSA_HAEDU
Sequence: MTDLPVDKILDTLGLRCPEPVMLTRKTIRHMQQGEILFILADDPATTRDIPSFCEFMDHQLLKSKTDTPPYEYWIKKGI
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG3_MAGO7
Sequence: MNSLYSVVNTLRDRYAPVSHTSTFRQTGEITPEEFVAAGDYLVFKFPTWSWGDADSESRRASHLPPGKQFLVTRNVPCNRRLNENFAGDAGLEEAVVDDGDEFKGSKGDDDGWLRTGGLSSSQPLKAREVRTVDDAGNAGERAQPDDDDDIPDMEDEEDDEAIIRDTDASGQTSSRRTYTLYIMYSPYYRTPRLYLSGYGANGQPLPPHNMMEDIMGDYKDKTVTLEDFPFFANNIKMASVHPCKHAPVMKTLLDRADAALKLRREKLKTGDASGQQAGLEGLADEFNKLGVSGKGDASKIDKNDEWEDIQHDDVADQEVAIRVDQYLVVFLKFIASVTPGIEHDFTMGV
What is the function of this protein?
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8.  The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE).  This step is required for the membrane association of ATG8.  The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity) (PubMed:30776962).  Plays a role in appressorium formation and pathogenicity (PubMed:30776962).
What are the official names of this protein?
Autophagy-related protein 3, Autophagy-related E2-like conjugation enzyme ATG3.
What is the protein family that this protein belongs to?
Belongs to the ATG3 family.
What are the subcellular locations of this protein?
Preautophagosomal structure. Cytoplasm.
Protein: RL3_ANASK
Sequence: MSTGLLAKKVGMTQIFTPEGDCVPVTVLEAGPCTVVRRKTAEKDGYDAVVIGFGVVDEKHAHRLSKPEVGVFKKAGTPIFRHVKEIRVKDAKQLGDLKAGDVLTVDKVFKANQRIDVAGVTKGRGFTGVMKRWNMKGAARDSSTAHEHHRHVGAIGQRKTPGKVWKGKHLPGHYGVDNVTIQNLTVVGIEAEQNVLLVSGAVPGHADGLLFVNTAAKGQPRIKQKQEVRERAKPKV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: COXX_ANAMM
Sequence: MTATFIKTSRGKSPASLSSVGDYVQLLKPRIMCLVVFTAITGMLIAPGTIHPLIGLVSTVCVALGAGAAGAFNMWYDSDIDAIMDRTKGRPIPAGKICREQAWECGMVLATLSVFVMAIAVNYVSALLLAGSIFSYAVVYTMLLKRRTPQNIVIGGIAGAFPPVIGWASVSGTLSLESLSLFAIIFVWTPPHFWAIALLTLEEYKKANVPMLPVYCIRKTRSHILLYSIILAVVGATPGLFVKHPVLYEILATGLSATFIAYAIAVFREKGQPSHKACMGLFKYSIYYLFLLFAVVIACVH
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YCGL_SALEP
Sequence: MRQVTIPLIQSKSMFCVIYRSSKRDQTYLYVEKKDDFSRVPEALMKGFGQPQLAMMLPLDGRKKLVNAELEKVKQALSEQGYYLQLPPPPEDLLKQHLSSVGQNTSPADR
What are the official names of this protein?
Protein YcgL.
Protein: RL10_BACMK
Sequence: MSKVIETKQQVVTEIAEKLRASKSTIVVDYRGLTVSEATELRKNLREAGVEFKVYKNSLTRRAAESAEMAELNEFLTGPNAIAFSNEDVVAPAKVLNDFAKNHEALEIKAGVIEGKLVTLDEVKAIATLPSREGLLSMLLSVLQAPIRNLALATKAVADQKEEQGA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: MURD_LIMRD
Sequence: MKKIDEYQGKKVLVMGFGISGINAAHLLVKLGANVTANDKATPKNNDIVDDLEADGIKVITGDNPISLANEGFDVVVKNPGIPYDNPLVAAFVKQGTPIITEAELGWQIFDGHLVSVTGSNGKTTTTTLTQLMIAENAKHQVKYAGNIGISFSKIAEDLGPDDTLVTELSSFQLLGAPTIHPHIAIITNIFSNHLDYHKTRENYINAKLNITRNQTKDDFLVINWDRDEWQKIAQRSQATIVPFSRLNKSHEGSYVEDGMIYWRGQEVMPTKDIRLIGPQNVENALAAIAAAKLSGVTNDAIKKVLTTFSGVRHRLQYVMEYQERLFYNDSKSTDIEATEVALQGFDRPVILLAGGLDRGYTFERLVPYFKKHVKAMIVFGECKDKMKDAGNQAGVPVVESENAITAVPEAWKLSEPGDVILLSPANASWDQFPSFEVRGDKFIEAVEELTGKKEQ
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METC_LACLC
Sequence: MTSLKTKVIHGGISTDRTTGAVSVPIYQTSTYKQNGLGQPKEYEYSRSGNPTRHALEELIADLEGGVQGFAFSSGLAGIHAVLSLFSAGDHIILADDVYGGTFRLVDKVLTKTGIIYDLVDLSNLEDLKAAFKAETKAVYFETPSNPLLKVLDIKEISSIAKAHNALTLVDNTFATPYLQQPIALGADIVLHSATKYLGGHSDVVAGLVTTNSNELAIEIGFLQNSIGAVLGPQDSWLVQRGIKTLAPRMEAHSANAQKIAEFLEASQAVSKVYYPGLVNHEGHEIAKKQMTAFGGMISFELTDENAVKNFVENLRYFTLAESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEALEDLLTDLKEALEKE
What is the function of this protein?
The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development.  Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha, gamma elimination.  With methionine as a substrate, it produces volatile sulfur compounds which are important for flavor formation in Gouda cheese.
What are the official names of this protein?
Cystathionine beta-lyase, CBL, Beta-cystathionase, Cysteine lyase, Cysteine-S-conjugate beta-lyase.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODC_ANACO
Sequence: MVKAVAVLGSSEGVKGTIYFTQEGDGPTTVTGSISGLKPGLHGFHVHALGDTTNGCMSTGPHFNPAGNEHGAPEDETRHAGDLGNVTVGEDGTVNVNIVDSQIPLSGSNSIIGRAVVVHADPDDLGKGGHELSKTTGNAGGRVACGIIGLQG
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPIL3_MOUSE
Sequence: MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCVFHRNIKGFMVQTGDPTGTGRGGSSIWAKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  May be involved in pre-mRNA splicing (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase-like 3, PPIase, CYP10L, Cyclophilin-like protein PPIL3, Rotamase PPIL3.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
Protein: RSMG_STRCO
Sequence: MSEAAELPPVPEQARDVFGDRYADAVRYAELLAEAGVKRGLIGPREVPRLWERHLLNCAVLSEVVPEGVTVCDVGSGAGLPGIPLALVREDLKITLLEPLLRRTNFLTEVVELLGLDHVTVVRGRAEEVMGKLPPVHVVTARAVAPLDRLATWGIPLLRPYGEMLALKGDTAEEELKAATAALSKLGAEQTSILHVGEGVVSPLSTVVRVEVGESPGGVRFAAKRAKAARTGRTRRRRG
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase, Glucose-inhibited division protein B.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD59_HUMAN
Sequence: MGIQGGSVLFGLLLVLAVFCHSGHSLQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCNFNEQLENGGTSLSEKTVLLLVTPFLAAAWSLHP
What is the function of this protein?
The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
What are the official names of this protein?
CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-inhibitory protein, MAC-IP, MEM43 antigen, Membrane attack complex inhibition factor, MACIF, Membrane inhibitor of reactive lysis, MIRL, Protectin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues.
Protein: SARZ_STAA8
Sequence: MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKEYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEFNISEREASDIINNLRNFVSKNFDYSDKK
What is the function of this protein?
Activates transcription of virulence factors alpha- and beta hemolysin genes (hla and hlb).  Also, activates RNAIII expression, a central regulator transcribed from the agr locus.
What are the official names of this protein?
HTH-type transcriptional regulator SarZ, Staphylococcal accessory regulator Z.
What is the protein family that this protein belongs to?
Belongs to the SarZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCDN_MOUSE
Sequence: MSCCDLAAAGQLGKAGIMASDCEPALNQAESRNPTLERYLGALREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALGVALLACFCSDPELASHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQRAEDASKFELCQLLPLFLPPTTVPPECHRDLQAGLARILGSKLSSWQRNPALKLAARLAHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVVTACYALMELGIQECTRCEQSLLKEPQKVQLVSIMKEAIGAVIHYLLQVGPEKQKEPFVFASVRILGAWLAEETSSLRKEVCQLLPFLVRYAKTLYEEAEEASDISQQVANLAISPTTPGPSWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTSVLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLAANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPDYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP
What is the function of this protein?
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling.  Required for the spatial learning process.  Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation.  May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction.  May be involved in bone metabolism.  May also be involved in neurite outgrowth.
What are the official names of this protein?
Neurochondrin, M-Sema F-associating protein of 75 kDa, Norbin.
What is the protein family that this protein belongs to?
Belongs to the neurochondrin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endosome membrane; Lipid-anchor. Cell projection, dendrite. Postsynapse. Note=Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation.
Protein: MSH3_ASHGO
Sequence: MLQQPTISRFFKSSSTRKKSEQRTAKEEAELMQLLESDGENNSATVPSDRKPEAAPMHVGLGNKAAAGGAVPGQVKSATRGFEDFRFNRRREACGKEQEVGFAERLQRIMERREGGCVEEDETELDNEAPRSKRAKPNRLTELDQQFKDLKLQHMDKVLAVRVGYKYKFFAEDAVMVSRVLQIKLVPGKLTVHETDPADHKHKKFAYCTIPDTRLEVHLQRLMHHNLKVGVVEQTETSAVKKNSGTSSSVFSREVTNIFTRATYGINETFGTKDRRVLGDSASVWGLVCKRQPSYTRYFLVSVNLNSGEVIFDDFKEERFLTEALETRIKYTNPSEVVVGDGLGSEIEKVFHTSDSDITLNRIELVGLYEEIFSEPHPAFKGNVPLQTALMLVHGYLTNFKNESLLFFKENFKPFCSKTHMILPSSAIESLDIFENSTDRSSKGSLLWVLDHTRTNYGLRNLKNWIAKPLINIDQIQQRLDAVQCISTEVGNIFIESLNNMLRDGQDLERILNRIAYGKTSRREVYLFLRELTQLATLFSSHHRYIETNVLSANGKIRMQSSLLANIFTDLDEYWKQFPIPNFLAMINIDAALDKNPDRPYVEYFNLTKYDRAEPLISKQQDIEAVIGELRDELKNIRVILKRPMLNYKDEIDFLVEIRNTQVSSVPVDWVKVASTKAVSRFQTPGTAKLVAKLQYHKELLQDLALQEYESFIKRITGEYTSLRKAILHLSTYDCILSLAATSCNVDYVRPKFNTAPQCINVINGRNPIIESLDVRYMPNDVNLNREGKKIMIITGPNMGGKSSYIRQVALLVIMAQIGCYVPAQEAEFSIFDQIFTRIGAYDNLLRNDSTFKIEMTEMVQILRSSTENSLLLLDEVGRGTGTHDGISISYALLRYFIELHNACPLILFITHYASLGSIRSPILGNYHMSYIEEKRPGENWPSVVFLYKLKEGRAHNSYGLNVAKLADIQTGIINRAYKISTMLKQEMESNSSIAAICTIKHALAGNSAASLKSAIETLIESADHEQFVLNM
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  MSH3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MSH3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBD_LOLPR
Sequence: MTIVLGRVPKEENDLFDTMDDWLRRDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCQLGGLWTFVALHGAFALIGFMLRQFELARSVQLRPYNAISFSGPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSAIGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ARGB_MYCUA
Sequence: MTIETLSTQSKAQVLAEALRWLKQLHGRVVVIKYGGNAMTDDTLRQAFAADMAFLRNCGIHPVVVHGGGPQITAMLGKLGIEGDFKGGFRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGVTGEDAQLFTAVRRSVNVDGVATDIGLVGDVDHVNAAALMDLIAAHRIPVISTLAPDAEGVVHNINADTAAAAVAEALGAEKLLMLTDVEGLYTSWPDRDSLVREIDTAALEQLLPRLEAGMIPKVEGCLRAVTGGVPSAHVIDGRVEHCVLVELFTNAGTGTKVVSA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U376C_CAEEL
Sequence: MKHFLLLAIIGILFLGSTYGASVATEKLKASNCTKTEGFQAIACVLRMADFAQKIEKLDMDDKNQVNEFEKSCVSFANCFETLQCGPEDPAEKKINNMIKNYCDAVVYVAKDFADCSEKLENKNSTCYQNWDPFPDAIDEETDEKKKEKMLQEACKNYFGKDNCLKKEITEKCSETEWKGFRDHFIGISNILLECDFRNIQ
What are the official names of this protein?
UPF0376 protein F10G2.1.
What is the protein family that this protein belongs to?
Belongs to the UPF0376 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.