PharMolix/UniProtQA huggingface dataset:
Protein: MDTC_SHIBS
Sequence: MKFFALFIYRPVATILLSVAITLCGILGFRMLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVSEMTSSSSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGKLYDFASTQLAPTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRTAISNANVRKPQGALEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGGAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDSIRAKLPELQETIPAAIDLQIAQDRSPTIRASLEEVEQTLIISVALVILVVFLFLRSGRATIIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVVLENIARHLEAGMKPLQAALQGTREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLLREFAVTLSVAIGISLLVSLTLTPMMCGWMLKASKPREQKRLRGFGRMLVALQQGYGKSLKWVLNHTRLVGVVLLGTIALNIWLYISIPKTFFPEQDTGVLMGGIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGMMFITLKPRDERSETAQQIIDRLRVKLAKEPGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKKLATLPELADVNSDQQDNGAEMNLVYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPMNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIDRAMTQLGVPSTVRGSFAGTAQVFQETMNSQVILIIAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRHGNLTPQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGSELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSRKPKQTVTE
What are the official names of this protein?
Multidrug resistance protein MdtC, Multidrug transporter MdtC.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMH_TROWT
Sequence: MNGHLPVMLGEVCQLIEPVLGIGDVFIDATLGAGGHSEAILMSSQGALLYGIDRDAYALALARKRLSGFADRCKFVHDTFDKFDKYLSNLHPKVFLFDLGMSSMQIDNPDRGFSYMKSGPLDMRMNESDKITAKEILNGYSETALIRIFRDYGQERYAKRIARQICKARSVSELVTTCQVSQLIRDVCPPHIRKGHPAKRVFQALRIEVNSELLFLRTALEKALDLLQVGGRIVVLSYHSLEDRIVKHLFRSVSVSQLPKGFYINKDPEYKLIGKDLKNPKETEIANNPRASSAHLRAVERVHSHSQAEAQIVEPRA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_UREPA
Sequence: MILSLNLLHKISPKLKKIPLNELCAALMDLGCEVETINSIKPSTNLVFAKVLEKTRHPNANHLNLVKVKANQKVYEIVCGANNFSVHNWVVLAKLNAELANGLKITPRELRGYVSNGMLCAYSEINPQATSFLTSTDLDGILVLDDNYDHYKTPNQIFNLDDVILDLSIPSNRNDLNGYFWIAKELCAYFDFEYVVDATINHRPHKEIIDVRILSDDVNSYGIIEVKNIQNYILKWNTKSILINNQIKVLNNFADNMNFLTLLTANPLHAFDARKISGQIVVKNAEEDAILLGLDQKEYLIKKGDLIIVDDQKILALAGIIGSNDSKIDATSTTAYIECANFNPMLIANTARRLKINTAAAMRFSKPLTNYVTKVTLKKLLANFKSDAKLIYYFKHSVHNVIKNKINQVSDFVGAEIDLDTAQTFLKRLGYKINKSNLITPSHRYDVLNEFDVYEDIMKKISIQEIKPQPISFDILNFENNLAYDFEKKVSDFLVDQGLFECKTYNLKNQTQAHEFNFFNFKQAYEINNPTSNMRSHLKLNNLNSLLEVLEYNQNQKNELENIFEISKINPVDSSQQTVLSIILCKPLINSKINDSLIVNNFVTTKALLHALLTKLNIDYAYDKNHVVNELYDNNQLALINANKQVFGFIGQLKNQVKKTYGLSNDIFIINLNLTSYLNQKQVITKVIKPSMYHDVIRDISVKLASDVDLNNIIANIKKIKNIRKVEISDLYIKDDGIIYTFKYYINDHLSNLSSEQIIIIEQEVNNYLKQF
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_GLAP5
Sequence: MDNKIIVALDYETEAEALNFVDQVDPSLCRLKVGKEMFTTLGTHFVKQLQDRKFDVFLDLKYHDIPNTVARAVRSAADLGVWMVDLHACGGLRMMETAKQILEPYGKDAPLLIGVTVLTSMEDLDLLQIGINASPMEQVIRLAHLCQRAGLDGVVCSPQEVEVLRTHCGKDFKLVTPGIRPEGSDFGDQRRVMTPKQAIEIGSDYLVIGRPITQAADPLAVLKSINQSIA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: HEM1_PSEPW
Sequence: MAFLALGINHKTASVDVRERVAFTPEQLVDALQQLCRLTASREAAILSTCNRSELYIEQDQLSAEAVLQWLADYHRLSLDELRASAYIHEEHDAVRHMMRVASGLDSLVLGEPQILGQMKSAYAVAREAGTVGPLLGRLFQATFSAAKQVRTDTAIGENPVSVAFAAVSLARQIFSDLGRSQALLIGAGETITLVARHLHEQGVRRIVVANRTLERASLLAEQFGAHAVLLADIPQELAHSDIVISSTASQLPILGKGAVESALKQRRHKPIFMVDIAVPRDIEPEVGELDDVYLYTVDDLHEVVAENLKSRQGAAQAAEELVSVGAEDFMVRLRELAAVDVLRAYRQQSERLRDEELQKAQRLLANGGNPEDVLAQLARGLTNKLLHAPSVQLKKLSAEGRLDALAMAQELFALNEGSTDKSLQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: DXR_RHOCS
Sequence: MVVSVTPRHSTGGDGIRSVTVLGSTGSVGSNTVELIEAYPERYRTVALVARRNVAALAGQARRLRPEVAVVADEAHYADLKDALAGTGIAAAAGPAAVVEAAQRPADWVMAAIVGAAGLEPTLAAARRGAIVAFANKECLVCAGELLMAEVRRHGATLLPVDSEHSAIFQVFDPERRPAVSRLILTASGGPFRTWTRERMAAATPKEACAHPNWTMGAKISVDSASMMNKGLEIIEACHLFGMPDGQIDVLVHPQSVVHSMVEYVDGSVLAQLGTPDMRTPIAVALGWPDRIATPGARLDLIKSSRLEFEAPDPLRFPALRLARHALQCGGAAPTLLNAANEVAVQAFLEERIGFLDIERVVEATLASLPHSELNDLDDVRTADADARRFASEMVAAGRGSR
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: DNAK_PORG3
Sequence: MGKIIGIDLGTTNSCVSVLEGNEPIVITNSEGKRTTPSVVAFVDGGERKVGDPAKRQAITNPTKTIYSIKRFMGETYDQVSREVERVPFKVVRGDNNTPRVDIDGRLYTPQEISAMILQKMKKTAEDYLGQEVTEAVITVPAYFNDAQRQATKEAGEIAGLKVRRIVNEPTAASLAYGLDKSNKDMKIAVFDLGGGTFDISILELGDGVFEVKSTNGDTHLGGDDFDHVIIDWLAEEFKSQEGVDLRQDPMAMQRLKEAAEKAKIELSSTSSTEINLPYIMPVNGIPKHLVMTLTRAKFEQLADRLIQACVAPCETALKDAGMSRGDIDEVILVGGSTRIPAIQEIVEKIFGKAPSKGVNPDEVVAVGAAIQGGVLTGEVKDVLLLDVTPLSLGIETMGGVMTRLIDANTTIPTKKSEIFTTAVDNQPSVEIHVLQGERSLAKDNKSIGRFNLDGIAPAPRQTPQIEVTFDIDANGILNVTAHDKATGKKQNIRIEASSGLSDDEIKRMKEEAQANAEADKKEKERIDKINQADSMIFQTEKQLKELGDKFPADKKAPIDTALDKLKEAHKAQDVAAIDTAMAELQTALTAAGEELYKNVGAAQGGAQPGPDFGGAQGPSVGDQPSDDKNVTDVDFEEVK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ATP23_YEAS7
Sequence: MNSSGDNAGFEWWRRTMQYKTGIGLTPEEKTRYEDDSKARELKKECLKCYEYRDWMLKYSPTVRFMVQAITKLNKGSDSKFDDSKIICDYCPDWKGGGFHPELGILLCQNRLRDKWHLEDTLSHELIHYFDDLKWQIDWLNLKHHACSEIRASSLSGECRFWEEFKRRGFRTGFHVARGHQDCVRRRAIISVSGNPNCQSKEHAAKIVDEVWDSCFADTRPFDEIYR
What is the function of this protein?
Has a dual role in the assembly of mitochondrial ATPase.  Acts as a protease that removes the N-terminal 10 residues of mitochondrial ATPase CF(0) subunit 6 (ATP6) at the intermembrane space side.  Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of ATP6 with the subunit 9 ring (By similarity).
What are the official names of this protein?
Mitochondrial inner membrane protease ATP23.
What is the protein family that this protein belongs to?
Belongs to the peptidase M76 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Associates loosely with the inner membrane.
Protein: CHSSB_CAEEL
Sequence: MVGGGRTGIHLLLGFLIGAALALFFFSSTPSIDLTSSLAAFTSCQNQETETNVLEPSALEKGRVYKDLSEHWIVHQDDMPAPPHNQDATPKVTRTRFAATELGTRERVMAAVMAESALALSINATLGRHVPRVHLFADSSRIDNDLAQLTNLSPYKLNGQKTHSMVLGLLFNMTVHNNYDWFLLAKDSTYINPFVLLRMIDTMNWNEPVVMGEAAEDGSGRCRLDTGMLLSQPAMHALMNNRNACNNFALAADDDQLAFEKCIQIATNLTCKPLHQGVRYEVWRGAERADSPAAHDSIEDWKHSPAFKRALAVPRLLSDADASALHDYFVRVEMQRADREIIKMEAELSRLAEQEARETGEAISWPPALPPYAKPPNRYQVSTWEYFTMTELFRSEPNQNVRRLEGKDFDDVAEVVVAARQQVESEEPELEFVQLRNGYRVFDPRRGMDYMVDLTYRKTVNEMPEVDNRFESDNEAAHEESLKEIVVERRVHVSRMIASTQLMNQAPYVKEDTDVTVVIPVASEKDVLPARKLLARQARLCLFPTEEARKTRMVVAVFPLIESRSVTAITNDMEELKRRCKRSLLETDVLPVHPAVSTEGKGTAAAAALDDAVDRYGANTIYLLLSPHADVQKEFFDRARINTIKHYQVFFPVPFVEYHPTISGMEMTEKEEKETPTEQAREAALSRLRDGVEPKRKRTLIVQKEHGRFDSQDFSCFAVYGVDYVTARAKFGQNERRNDLISAFLGQDSIHVLRAVEPTLRIRYHKRSCDMESIDTEDIARCLDSKKENVAAKDQLAKLLFHEK
What is the function of this protein?
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity.  Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity).  Required together with sqv-5 for the biosynthesis of chondroitin (PubMed:15485872).  Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development (PubMed:15485872, PubMed:16982046).  May have a specific role in unc-6/netrin-mediated dorsal guidance of gonadal distal tip cells (PubMed:16982046).  Glycosyltransferase activity is weak (PubMed:15485872).
What are the official names of this protein?
Chondroitin sulfate synthase mig-22, Abnormal cell migration, Chondroitin-polymerizing factor, ChPF, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Protein: METK_ERYLH
Sequence: MRSTYLFTSESVSEGHPDKVSDQISDAIVDLFIGKDPEARVACETLTTTERVILAGEIRGQGIMDTDGNWAPGIEDEIEAAVRQTVKEIGYEQDGFHWETLTFENHLHGQSAHIAQGVDASGNKDEGAGDQGIMFGFACDETPDLMPAPIDYSHKILHRLATDRKNGNAPFLEPDSKSQVTLRYENGKPVACTAVVVSTQHGAGYDEGEKEAELRAYVKRVVADILPDGFLSDATKWHINPTGTFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYITRYLAKNVVAAGLATRCTIQIAYAIGVSQPLSLYVDTHGTGTVDDAAIEEAILDIEKLGGLTPRAIRTHLGLNKPIYRVSAAYGHFGRTAEGDRFPWERTDLVEDLKAALA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KATG_FRATM
Sequence: MLKKIVTALGMSGMLLASSNAIAEDTTTKNDNLSPQSVDLSPLRNLNKLDSPMDKDYNYHQAFKKLDTEQLKKDMQDLLTQSQDWWPADFGNYGPFFIRLSWHDAGTYRIYDGRGGANRGQQRFSPLNSWPDNVNLDKARQLLWPIKQKYGDAVSWSDLIVLAGTVSLESMGMKPIGFAFGREDDWQGDDTNWGLSPEEIMSSNVRDGKLAPAYAATQMGLIYVNPEGPDGKPDIKGAASEIRQAFRAMGMTDKETVALIAGGHTFGKTHGAVPEDKVKQAIGPAPDKAPIEQQGLGWHNSYGTGNGDDTMGSGLEGSWTSTPTFWNHDFLHNLYNLDWKKTLSPAGAHQWTPTNAKPENMVPDAHKPGVKHKPIMFTTDLALKEDDGFNKYTQEFYNNPEEFKEEFAKAWFKLTHRDMGPKSRYIGPWIPEQNFIWQDPVPAADYKQVSTQDIAQLEQDIINSGLTNQQLIKTAWDSASTYRKTDYRGGSNGARIALAPEKDWQMNEPAKLEVVLTKLKEIQTNFNNSKADGTKVSLADLIVLGGNVGVEQAAKQAGYNIQMPFVPGRTDATQAQTDIESFNYLKTKSDGFINYTDGSVSADKLPQTLVEKASMLDLNIPEMTVLVGGMRALDVNYDNSQKGVLTTTPGQLNNSFFVNLLDMSTQWKKSDKKDGEYIGIDRKTGKQKWTASPVDLIFGSNSELKAVAQVYAENGNEQKFVNDFAKAWHKVMMLGRFDVQQ
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: UB2L6_BOVIN
Sequence: MTASKRVAKELEDLQKELPKYLRNLCSEEDNVLVWHALLLPERPPYNLKAFRLCISFPREYPFQPPTVKFTTRIYHPNVDRDGRVCLPIISKKNWKASTRTCQVLEALNMLVNQPEPGQPVRLELAEQLTQDPELFDQMAQEFTLQFGVDRPS
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.  Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
What are the official names of this protein?
Ubiquitin/ISG15-conjugating enzyme E2 L6, E2 ubiquitin-conjugating enzyme L6, Ubiquitin carrier protein L6, Ubiquitin-protein ligase L6.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: SLYA_SERP5
Sequence: MESTLGSDLARLVRVWRALIDHRLKPLALTQTHWVTLHSINRLPPEQSQIQLAKAIGIEQPSLVRTLDQLEEKGLITRHTCANDRRAKRIKLTEAADPIIREVDSVISSTRGEILSGITTDEVQLLVGLIGKLEQNITELQNKQ
What is the function of this protein?
Transcription regulator that can specifically activate or repress expression of target genes.
What are the official names of this protein?
Transcriptional regulator SlyA.
What is the protein family that this protein belongs to?
Belongs to the SlyA family.
Protein: PPR37_RAT
Sequence: MEIPPQEAPPGPGADADADAEAEEAPAEAGSSSGASPPTDGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEVISAYRQACQKLNCRQIPKLLRQLQEFTDLEQRINCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLQELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMALPHTQSLETLNLGHNPIGNEGVRNLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEPVKSFIETQKALLAEIQNGCKRNFVLVREREEKQQLQPSASMPEITITAPQPLEESGDLPAMGAQNGTPGPGPGPDSDSDSDSDREEQEEEEEDQSDQQRDEGGTDQSSSAPCPALLPSTDSLGPGDKSPPGSPSSPTEQRISVSSPGRGHKVFVVTRVESPPERPEPPVPPTSVSSPPPSPPSPPASPPSQTMDTQDPESSEAQPQTEPSQAGQPLPNGLKPEFALALAPEAPPGLEAKGSSCSLEHALHRSHGVSKLEELLLEASQEAPRDTL
What is the function of this protein?
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 37, Leucine-rich repeat-containing protein 68.
What is the protein family that this protein belongs to?
Belongs to the PPP1R37 family.
Protein: LEUD_BRUSI
Sequence: MDKFTKLTGVAAPLPIVNIDTDMIIPKDYLKTIKRTGLGKGLFAEMRFNEDGSENPDFVLNKPGYRKAQILVAGDNFGCGSSREHAPWALLDYGIRCVISTSFADIFYNNCFKNGILPIKVAQEDLDKLMDDASRGANATLTIDLETKQIHGPDGGTISFDLDDFKRHCLLNGLDDIGLTMEKAKSIDTFEAKNAEERPWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: CLPP2_CHLMU
Sequence: MTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPTKDIQIFINSPGGYITAGLAIYDTIRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRMMIHQPSGGIIGTSADIQLQAAEILTLKKHLSNILAECTGQPVEKIIEDSERDFFMGAEEAIAYGLIDKVVSSAKETKDKNIVS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_SALEP
Sequence: MSIILGIDPGSRITGYGVIRQVGRQLTYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: Y1291_LEPBL
Sequence: MKFTVRVKPNSKKIFFRKEEDGSVTIAVREPALEGKANEAVIETISREMKIPKRKIRIVSGEKGKKKTIEIDP
What are the official names of this protein?
UPF0235 protein LBL_1291.
What is the protein family that this protein belongs to?
Belongs to the UPF0235 family.
Protein: RECO_BACAN
Sequence: MFQKVEGIVIRTTDYGETNKIVTIFSRELGKVSAMARGAKKPKSRLASVSQLMTHGHFLIQMGSGLGTLQQGEIISTMKEIREDIFLTAYASFIVELTDKATEDKKHNPYLFEMLYQTLHYMCEGVDPEVLSLIYQTKMLPVLGMRPYFDTCAICHQETDFVAFSVREGGFLCSRHAEQDQYRIPVGEAVHKLLRLFYHFDLHRLGNVSVKDSTKKQMRLVLNTYYDEYCGIYLKSRRFLEQLDKFQI
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: SAT_THIDA
Sequence: MSKLVRPHGGGELKPLLLTGDALSAEKARAASLPQLKMSSRETGDLIMMGIGGFTPLDGFMTKSDWQGVCDGYKMTNGLFWPIPITLSTDDESIKDGDELALVDAETGEIMGTMKVTDKYTIDKAHECMQVYKTTDMEHPGVKMVMAQGKYNLAGPVKVLSTGNFKEEYGEQFMTPAETRAKFEQMGWSRVAAFQTRNPMHRSHEYLAKIAIETMDGVLVHSLLGALKPGDIPAEVRSEAIATLIDNYFAPNTVIQAGYPLDMRYAGPREALLHALFRQNYGCSHLIVGRDHAGVGDYYGPFDAQKIFDEIPKGSLETVNMNIDWTFWCKKCGGMASQRTCPHTKDDRILLSGTKVRAMLSEGQDLPVEFSRPEVAKVLQKYYAGLSAEQNVKVELKGHSAA
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the sulfate adenylyltransferase family.
Protein: ISPG_NEIMA
Sequence: MNTLQRRKTHQVRIDHITVGSEAPVVIQSMTNTDTADAKATALQIKELSDAGSEMVRITVNSPEAASKVAEIRRRLDDMGYATPLIGDFHFNGERLLAEFPECGKALSKYRINPGNVGKGVKGDEKFAFMIRTAAENDKAVRIGVNWGSLDQSLAKRMMDANLASSAPKPPEEVTKEALIVSALESAEKAVLLGLPEDKIILSCKVSAVQDLIQVYRELGSRCAYPLHLGLTEAGMGSKGIVASTAALSVLLQEGIGDTIRISLTPEPGSPRTQEVVVGQEILQTMGLRSFTPMVTACPGCGRTTSTVFQELAQDVQNYLRQKMSIWRTLYPGVESLNVAVMGCVVNGPGESKLADIGISLPGTGETPVAPVYVDGERKVTLKGDNIATEFLAIVEEYVKTNYGENGSKRNQNKIIPIQSL
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: PUS3_BOVIN
Sequence: MAENDVDRIQTEKLLKRVQELEQEVKRLKKEQANNKDSNIRENSSGAGGKPKRAFDFSAHGQRHVALKIAYLGWGYQGFASQENTSNTIEEKLFEALTKTRLVENRQTSNYHRCGRTDKGVSAFGQVISLDLRSHIPKGRDSEHFNLKNEVNDVATEIRYTHILNRVLPPDIRVLAWAPVETSFSARFSCLERTYRYFFPRANLDIVTMNYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQRVGQNLGEEGWQEPFQLCQFEVTGQAFLYHQVRCMMAVLFLIGQGMEKPEVIDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENIKWIYDREVQEFNVTHLQQLWANHAVKTQMLYSMLQGLDSVALPCGTGPKMDGMIEWRNVKPSVTKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCSDTLEEENTVFEKPMKRICVDTELKSII
What is the function of this protein?
Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine(38/39) synthase, tRNA pseudouridine synthase 3, tRNA pseudouridylate synthase 3, tRNA-uridine isomerase 3.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GST3_CAEEL
Sequence: MVHYKLTYFNARGLAEISRQLFHMAGVEFEDERINEEKFSQLKPTFPSGQVPILCIDGAQFSQSTAIARYLARKFGFVGQTAEEELQADEVVDTFKDFIESFRKFVIAVLSGESEEILKNIREEVIKPAVKTYTAYLKAILEKSSSGYLVGNELTWADLVIADNLTTLINAELLDIENDKLLKEFREKIIETPKLKEWLAKRPETRF
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 3, CeGST3, GST class-sigma.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Sigma family.
Protein: RPOB_JANMA
Sequence: MHYSFTEKKRIRKSFAKRANVHNVPFLLATQLESYHGFLQEDKIPSQRKNEGLQSAFTSIFPIVSHNGFARLEFLSYVLGDPPFNIKECQQRGLTYASPLRAKVRLVILDKESPTKPVVKEMKEQEVYMGELPLMTSTGSFVINGTERVIVSQLHRSPGVFFEHDRGKTHSSGKLLFSARIIPYRGSWLDYEFDPKDILFFRVDRRRKMPVTILLKAIGMTPEQILENFFVFDDFALHADGAEMAFVAERLRGEVARFDITDKAGKVLVAKDKRINSKHVRDVEAAGIKNISVPEDYLLGRILAKNIVDKETGEVIANANDELTEDLLARLREGKVTHIQTLYTNDLDQGGYISQTLRMDDTTDQMAAKVAIYRMMRPGEPPTEDSVEALFNGLFYNADRYDLSAVGRMKFNRRIGRDELTGDMTLSNDDVLAVIKILVELRNGRGEVDDIDHLGNRRVRCVGELAENQFRAGLVRVERAVKERLGQAEADNLMPHDLINSKPISAAIREFFGSSQLSQFMDQTNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLALYARLNEYGFLETPYRKVEGSKITDQIDYLSAIEEGRYIIAQANATIDKSGALSDELVSAREAGETILVSPERVQYMDVAPGQVVSVAASLIPFLEHDDANRALMGANMQRQAVPCLRPEKAFVGTGIERTVAVDSGTTVQALRGGIVDYIDAGRVVIRVNDDEAQAGEVGVDIYNLIKYTRSNQNTNINQRPIVQVGDRVAKHDVIADGASTDLGELALGQNMLVAFMPWNGYNFEDSILISEKVVADDRYTSIHIEELSVVARDTKLGAEEITRDISNLAENQLARLDESGIVYIGAEVTAGDTLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPSGMVGTVIDVQVFTREGIPRDKRAQQIIDDELQRYRLDLNDQLRIVEGDAFQRLEKMLIGKVVNGGPKKIAKGAKITKEYLDDLDKYHWFDIRPADDTSANALEAIKESIAEKRHQFDLAFEEKRKKLTQGDELPPGVQKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSRILPIEDMPHMADGTPADVVLNPLGVPSRMNVGQVLEVHLGWAAKGLGLRIGEMLNAQVQIAELRKFLAAIYNESGKTEDLDSFSDAEILELAGNLKNGVPFATPVFDGADEGETRRMLDLAYPDHIAKQLGMTASKNQVTMYDGRTGEAFERTVTVGYMHYLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASYVLQEMLTVKSDDVNGRTKVYENLVKGDHVIDAGMPESFNVLVKEIRSLGIDIDLERD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CHLA_DICDI
Sequence: MDTNIINHYDIIIIGGGIAGLSATRHLLLKMPELSGRIAVIEPRSERRDNLDEDYKVGESTVEVSAMFFAKELELQDYLIENHPPKFSLQFHWPRELSKTDTIEDYYSTWAVKNPDIQAFQLNRCKIERDLLKMVIAQGAVYYHGRVRNVDNLDNDDMKSIDVEILSEVESGADFKLQQSIERITLTTDYIVDASGRNFTVGSRTDNILKDPKHLFGLDNASTWVRVKNTERSLFDFKSQDVTCSWTYDTNHFFGPGYWIWMIPLERGSRDYSIGVSYHRDKIQPSQLNSLDKFMSFLEKNQKLLYNLIKSGEIVDFHRWPKLAHTSKTFFSKNNWCVIGDAAAIFDPFYSTGMVMIAMEIECLTEMLKFKLSNAANDYHRRVEAFDKLIRCVTQINNHLIKDHSNHLGNASIMSWRIYFESSTYFSILLPAYIGKYHLCPIFSDHFTTDHENGLALRNQLLATLDYANENSINIGFMDNHRGGQLLGDWSPTSSWDYDHALSLAKYGHKRLNLPKCLSWSNFYLSLIICKLYYRVYGIGALWNSSFFKSLSNTTYRFSKFYFLSKLHSFNMIGTPNNDYYDKIQKDFKSYNYNQNNIVDWKY
What is the function of this protein?
Flavin-dependent halogenase; part of the gene cluster that mediates the biosynthesis of DIF-1 (Differentiation Inducing Factor-1), a signal molecule involved in the differentiation of pstO (prestalk-O) cells (PubMed:20231486).  The three-step process begins with the formation of (2,4,6-trihydroxyphenyl)-1-hexan-1-one (THPH) by the polyketide synthase StlB (PubMed:16906151).  THPH is then dichlorinated by the flavin-dependent halogenase ChlA (PubMed:20231486).  The last step of DIF-1 biosynthesis is the O-methylation of dichloro-THPH (or des-methyl-DIF-1) by the methyltransferase DmtA to yield DIF-1 (PubMed:9446571).
What are the official names of this protein?
Flavin-dependent halogenase chlA, Chlorination protein A.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: ESXN_MYCTU
Sequence: MTINYQFGDVDAHGAMIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA
What are the official names of this protein?
ESAT-6-like protein EsxN.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the ESX-5 / type VII secretion system (T7SS).