PharMolix/UniProtQA huggingface dataset:
Protein: PARC_STAAW
Sequence: MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKCDAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERLSLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKHQEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKILQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYTNGSFIVDTDDFGEVIDMYIS
What is the function of this protein?
Topoisomerase IV is essential for chromosome segregation.  It relaxes supercoiled DNA.  Performs the decatenation events required during the replication of a circular DNA molecule.
What are the official names of this protein?
DNA topoisomerase 4 subunit A, Topoisomerase IV subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MURG_BURTA
Sequence: MTSTPRTLMVMAGGTGGHVFPGLAVAHRMQAQGWRVVWLGNPAGMEATLVPKHGIPMEYVRFGGLRGKGLATKLALPFNLLRACAQSLRALRRVKPDVVLGMGGYITFPAGLVTVLTGRPLVLHEQNSIAGLTNKVLAKLAKRVLVAFPGALPNAEWTGNPIRAELARTEPPQARYAARSGKLKLLVVGGSLGAAALNEVVPRALALLAPSERPQVVHQAGAKHIDVLKENYEAAGLACGSDVELVPFIDDMASAYASADLVICRSGAMTVAEIAAVGVAALFVPFPHAVDDHQTTNAEFLAEQGAAVLVQQRDLSAELLADWLRGQSRESLAAMAERSRSLAKPDATDEVARVCAAVAGANLEGKQ
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MYOA_DICDI
Sequence: MATFKRDLTKNVGVEDLIMLTEVSESSLHENLKIRYKEGLIYTSIGPVLVSMNPYKQLGIYGNDQINLYKGKHEFEIPPHIYSIADKAYRALRSEGENQCIIISGESGAGKTEASKYIMQYIASITGSSTEVERVKKTILESNPLLEAFGNAKTLRNNNSSRFGKYMEIQFNLGGDPEGGKITNYLLEKSRVINQTQGERNFHIFYQLLKGSSEEEKKTYNLLSPDQYHYLTRNASNGCFTADGIDDQIGFKQTKNAMKVVGIDEPLQKEIFATLSAILLLGNLSFNKSASGNGSVISDKKLANTIASLMGVDAIVLESSLVSRQISTGQGARISTYSVPQTVEQAMYARDAFAKATYSKLFDFIVRKINQSIEVKTIGKVIGVLDIYGFEIFENNSFEQFCINYVNETLQQIFIDLTLKTEQEEYVQEGITWIPVQYINNKACVDLIEKKPIGILSLLDEECLFPEGNDQTMIDKLNKHFSNHTHYSKVERQKNSQFIINHYAGKVFYNIDGFLDKNRDTLFNDLVTLATSSSCSLLVEIFKYVPPLEVDPEQEKKNRDKFSKNGFANNAAKTFIPTDKKRPITAGFQFKNQVTSLLKSLYSCSPHYVRCIKPNSNMRALEWDQSKCAEQVAYLGLFENLLVRRAGYCYRQTFSKFMRRYYMIGKSTWPKWSGDAEKGVNLLMGELTQEINIKEEVQYGKTKIFIRNPQPLFLLEDKRNKRLNDLATKIGSVWKMYKQRKWYLRTLAAIKIQRTYRGWLLVRECVKLKNQSISIFQNNKERNRQSIKLSKAAFIGDFLSLTRDNYTTATLKREEGPNAVLQLSLNVSKVSRHHKIQKRSLLVTNETIFTITPHKPKKDGSWFAIKRKVPFSAIEKISFSKLSDDFFVIHIINEHDLCLETNKKTVLITLLSNLYSKHLNGKELVFEFKDSIQYRNQKGPSELKFVKVDSIHEKSSNSPQANSPSFTAKAEKNYLKVCVLPGLSSESKSILIEK
What is the function of this protein?
Actin-based motor protein, possibly involved in a wide range of motile processes, such as cell movement across a surface, and extension and retraction of pseudopodia or lamellipodia.
What are the official names of this protein?
Myosin IA heavy chain, Myosin-like protein abmA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Protein: MUTL_ECOK1
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTISLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRAIPENRVAAGRNHFAEPAVREPVAPRYSPAPASGSRPAASWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEVPVCAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: MUNS_REOVD
Sequence: MASFKGFSANTVPVSKAKRDISSLAATPGLRSQSFTPSVDMSQSREFLTKAIEQGSMSIPYQHVNVPKVDRKVVSLVVRPFSSGAFSISGVISPAHAYLLECLPQLEQAMAFVASPESFQASDVAKRFAIKPGMSLQDAITAFINFVSAMLKMTVTRQNFDVIVAEIERLASTSVSVRTEEAKVADEELMLFGLDHRGPQLVDVSDAKGIMKAADIQTTHDVHLAPGVGNIDPEIYNEGRFMFMQHKPLAADQSYFTLETADYFKIYPTYDEHDGRMADQKQSGLILCTKDEVLAEQTIFKLDAPDDKTVHLLDRDDDHVVARFTKVFIEDVAPGHHAAQRSGQRSVLDDLYANTQVISITSAALKWVVKHGVSDGIVNRKNVKVCVGFDPLYTLSTHNGVSLCALLMDEKLSVLNSACRMTLRSLMKTGRDVDAHRAFQRVLSQGYTSLMCYYHPSRKLAYGEVLFLERSNDVTDGIKLQLDASRQCHECPVLQQKVVELEKQIIMQKSIQSDPTPVALQPLLSQLRELSSEVTRLQMELSRAQSLNAQLEADVKSAQSCSLDMYLRHHTCINGHAKEDELLDAVRVAPDVRREIMEKRSEVRQGWCERISKEAAAKCQTVIDDLTLMNGKQAQEITELRDSAEKYEKQIAELVSTITQNQITYQQELQALVAKNVELDALNQRQAKSLRITPSLLSATPIDSVDDVADLIDFSVPTDEL
What is the function of this protein?
Non-structural protein with ssRNA-binding activity.  Is probably involved in the formation of viral inclusions, where the assembly of cores and the replication of viral RNA are thought to occur.  Together with mu-2, recruits the other core proteins to these inclusions (By similarity).
What are the official names of this protein?
Protein mu-NS, MuNS.
What is the protein family that this protein belongs to?
Belongs to the orthoreovirus mu-NS protein family.
Protein: RSGA_ACTPJ
Sequence: MSKRRLTQNQQRRIKSNHHKKIAKPELEWQDEMLGEVQQGIVVTRHAKHADVETEQGEIYRCNLRRTLKNVVVGDQVSWRKGNEQLQGISGVIEAIYPRKNELSRPDYYDGIKVMAANIDQIIIVSAVLPTLSLNIIDRYLVICETAKIPALIVLNKIDLLSESERQEVQKQLAIYENIGYETLCLSADTGENMEKLDRYLSRGTSIFVGQSGVGKSSLINQLLPEVNALTGAVSDISGLGQHTTTSSRLYHLPQGGNLIDSPGIREFGLWHLEPEQITLGYREFQSVLGTCKFRDCKHKSDPGCAVREAVEKGEINAIRFENYHRLIESRDETKSQRHFRTEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_PSEAE
Sequence: MNPVSLIFLAFAMSTDAFAAAIGKGSSLDRPRLSEALRTGIIFGVIEAITPLVGWLLGQAASQFVADWDHWIAFVLLVLLGLHMIHNGLRADHATEQEKPGQHSFWILAVTALATSIDALAVGVGLAFVDVNIFLAAGAIGLATMTMVTLGTMLGRALGAVTGKRAEMVGGVVLILVGATILYEHLSAA
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DUT_HELP2
Sequence: MKIKIQKIHPNALIPKYQTEGSSGFDLHAVEEVTIKPHSVGLVKIGICLSLEVGYELQVRTRSGLALNHQVMVLNSPGTVDNDYRGEIKVILANLSDKDFKVQVGDRIAQGVVQKTYKAEFIECEQLDETSRGSGGFGSTGVSKA
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: GLCT_STAAC
Sequence: MGEYIVTKTLNNNVVVCTNNDQEVILIGKGIGFNKKEGMALNDQTITIEKIYKLESEQQKAHYKSLVEIADDNVLQVIIDSLNFISNTAMNVDSKQLVVSLTDHIIFAYKRLKQNQVISNPFVMETMQLYSDAYHIAKQVIDQLNAALDVHFPEDEIGFIALHIASNTEDLSMHEMTLINNVIKKGIDIIESDLVTTVDKESLQYQRFIRHVQFLIRRLRRKEYIHAQDDFVSMIKNHYPICYNTAYKILTMIQKQFDVNISESEIIYLTLHIHHFEERINQS
What are the official names of this protein?
Protein GlcT.
What is the protein family that this protein belongs to?
Belongs to the transcriptional antiterminator BglG family. GlcT subfamily.
Protein: RPOA_OLTVI
Sequence: MKHILLSCVESRIEHNRSFYSRFQLGPFDLGQGLTVGNAFRRTLLSELSGVGITLIEIDGVCHEYSTLPGVRESVLDILLNLKQLVLTSDTTFTVPQVGYLNFTGPGVVTAKDLKLPVSVYCVDPDQPIATLSADATLNFKFLVCQGKNYIIQTPVDKFHEYQKKILNSKLNLPLSSRTTLNSTFERPNQDSLVGTPLQEGVGKTKQNKRLNAHFQRQLKQLNRLKETSFKAYKTKVGEKTISDEFQTNSVNHQNLTTFDLREKKLTDVTTSLQHGEEATLLKEEGLNKLDNSSPQLENKLKGGRDFSGGSQLASQALPVDTLFMPIKKVNYMIDIDPAEPDRESVVLEIWTNGSIHPRQAVHEAAKQLIHLFSPFLQTHLVPTTLQSTPYSKAASKTQEFSLNETSTEKVKDELGKVAFGSENNTAALNQQKNLVTAIQTLDIANLNFSLRTFTFLKKENINTVSELVEFWTRQKTEAKDSIQSNVQSSVLLEISNNLKNFGVLPTS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MATK_TIGPA
Sequence: MEELQGYLEKDRSRQQPFLYPLLFQEYIYALAHDRGLNDSIFDKPVEVFGYDSKSSLALVKRLIIRIYQQNYFLSAVRSFNQNRFLGHHHNNFFYSHFDSQMISEGFAIIVEILFSLRLVSFFEKKEIKKFHHLRSIHSIFPFLEDKLLHLNYVSDILIPHPIHMEILVQILQCWIPDVPLLHFLRFFLHKYHNWNSFLITPKKSIYVFSKENQRLFRFLYNSYVSECEFLLVFLRKQSSYLRLTSFGLFIERRHFYVKIEHLHMQHLLFIVVCRDYFHGTLWFFKDPSMHYVRCQGKAILASKGTHLLMKKWKYNFVNLWQYYFHFWYQSYRIRINQLANYSFYFWGYLSSLLKNYSTVKNKMLENSFLIDTVTNKFEATVPVIFLIGSLSKAQFCTVSGHPISKPTWTDLSDSDIIERFGRMCRNLSHYHSGSSKKQGLYRIKYILRLSCARTLARKHKSTVRTFLXRLGSGLLEEFFTEXDQALSLILPKKIPFIFHGSHKKHIWYLDIIRMNDLVNHS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 5HT6R_HUMAN
Sequence: MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.  The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.  It has a high affinity for tricyclic psychotropic drugs (By similarity).  Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity).  Is an activator of TOR signaling (PubMed:23027611).
What are the official names of this protein?
5-hydroxytryptamine receptor 6, 5-HT-6, 5-HT6, Serotonin receptor 6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HYEP_RAT
Sequence: MWLELVLASLLGFVIYWFVSRDKEETLPLGDGWWGPGSKPSAKEDESIRPFKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSNYMKKVVSYWRNEFDWRKQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPKSHGLSDEHVFEVICPSIPGYGYSEASSKKGLNSVATARIFYKLMTRLGFQKFYIQGGDWGSLICTNMAQMVPNHVKGLHLNMAFISRSFYTMTPLLGQRFGRFLGYTEKDIELLYPYKEKVFYSIMRESGYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFSLDDLLVNIMIYWTTGTIVSSQRYYKENLGQGIMVHKHEGMKVFVPTGFSAFPSELLHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAELQ
What is the function of this protein?
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.  May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids.  Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity).
What are the official names of this protein?
Epoxide hydrolase 1, Epoxide hydratase, Microsomal epoxide hydrolase, mEH.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: NB2_MYCTO
Sequence: MTRDLAPALQALSPLLGSWAGRGAGKYPTIRPFEYLEEVVFAHVGKPFLTYTQQTRAVADGKPLHSETGYLRVCRPGCVELVLAHPSGITEIEVGTYSVTGDVIELELSTRADGSIGLAPTAKEVTALDRSYRIDGDELSYSLQMRAVGQPLQDHLAAVLHRQR
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase 2, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: HPNN_BURTA
Sequence: MLTSVLVRLVAWSVRRPIWVVVLSLVAAALSGVYVAHHFKINTDISKLVENDPKWAALGHAIDDAFPQRSQTILAVVEAPAPEFAAAAANALADGLRREAEAGRIGQVSEPGGGPLFEHDGLLFLPEQDVATTTAQLASARPLINVLAKDPSIAGLATTLSTTLGVPLQSGQVKLSGMAKLLSRSAATVDDVLAGKPAAFSWRALVDADAAREPARAFVTVQPVVNYGALQAGEQASRTIRATAQALKLDERFGAAVRLTGEQPLADEEFASVQDGALVNGIATLAIVLVILWIALRSKRMIAAVFVTLFVGLVVTAALGLMMVGSLNMISVAFMVLFVGLGVDFAIQYGVKYREERHRDPNLEHALVGAAHAMGMPLTLATAAVAASFFSFLPTAYRGVSELGLIAGVGMFVALFTTLTLLPALLRLLAPPGERKPPGFPRLAPVDDYLDRHRKPILIGTLAVVIGALPLLAHLRFDFNPLHLKDPHSESMATLLALKDSPEASVNDVSLLAPSLAAANAAAQRLGALPEVGRTTTLSTFIPDAQPQKLATIAAAARELLPALTQPAAAPVSDAQRVAALKRASNLLEYAAEDYPGPGAAAAKHLSESLAKLAAADAATRERAEHAFSAPLKIALNQLAMLLQPSEITRKNLPPQIVRDWVAPDGRALVQISPKVPKGADPGDDAMLRRFAKAVKAAEPGTIGGPISILHSADTIIRAFLQAAALSVVSITVLLWITLRRFGDVLRTLVPLLVSGVVTLELCVLLGMPLNFANIIALPLMLGVGVAFKVYFVMAWRAGQTGLLQSSLTHAVLFSAATTATAFGSLWLSHHPGTASMGRLLALALSCTLIGAVVFQPVLMGKPRTKRVTNQSQGIDE
What is the function of this protein?
Essential for hopanoid transport from the cytoplasmic to the outer membrane (By similarity).  Is capable of shuttling hopanoid lipids from the inner membrane to the periplasm, where they probably spontaneously insert to the inner leaflet of the outer membrane, strengthening the cell envelope (By similarity).  May be a proton-motive-force (PMF)-dependent transporter (By similarity).  Is critical for multidrug resistance and cell wall remodeling in Burkholderia (PubMed:28584102).
What are the official names of this protein?
Hopanoid transporter HpnN.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
Protein: GP7D_CHLT2
Sequence: MGSMAFHKSRLFLTFGDASEIWLSTLSHLTRKNYASGINFLVSLEILDLSETLIKAISLDHSESLFKIKSLDVFNGKVVSEASKQARAACYISFTKFLYRLTKGYIKPAIPLKDFGNTTFFKIRDKIKTESISKQEWTVFFEALRIVNYRDYLIGKLIVQGIRKLDEILSLRTDDLFFASNQISFRIKKRQNKETKILITFPISLMEELQKYTCGRNGRVFVSKIGIPVTTSQVAHNFRLAEFYSAMKIKITPRVLRASALIHLKQIGLKDEEIMRISCLSSRQSVCSYCSGEEVSPLVQTPPIL
What are the official names of this protein?
Virulence plasmid integrase pGP7-D, Protein P-11.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: LOLF2_EPIUN
Sequence: MTLTNLDAIVVGAGFSGILAVYRLRKLGFRVQGFERQERLGGVWRENAYPGAAVDSLFPFYQFYDAELLQDWEWGEQFPTRAEMLRYFDHVDKRWEISASFEFGVSVSAARYSETTQRWTVTLEDGRRAEARWFIPAVGFSSVLNIPRIPGMSRFRGAIYHTAKWPHDAVSMRGKRVAVIGTGPSGVQIIQSVGKIAKAMTIFQQSPCLTLRKYGSPNQTATALCMRPDDHREALRLGLQTSNGFGYVPRDQDTLDVPIEERNHFYQQRYLAGGWAFWMAGFRDLCQNIQANRDAYDFWARRTRARIGDVTKRELLVPQIPSFAFGIKRPCLEEDLYEIMDQPHVKIIDISNQQIELITETSIRVHGQTVECEAIIFATGFGDEASGLRSLHIRGRNGIRLEDAWSDGVESHLGMAIHSFPNMFFLYGPQCPTLLVNSPAVITVQVEWLCEIISKCQQAGICQLEATSKSHCQWEKKMSLLWDKTLYHTHARKSKKTAEANKEEKTWVGGLILYRRELENCLANNLEGFQAWYVEETALL
What is the function of this protein?
FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of loline alkaloids, potent insecticidal agents composed of a pyrrolizidine ring system and an uncommon ether bridge linking carbons 2 and 7 (PubMed:15654104).  Lolines are structurally differentiated by the various modifications of the L-amino group and include norloline, loline, N-methylloline, N-acetylloline, N-acetylnorloline, and N-formylloline (PubMed:15861432, PubMed:25531527).  The first committed step is the condensation of O-acetyl-L-homoserine (derived from L-aspartic acid) and L-proline, probably catalyzed by the gamma-type pyridoxal 5'-phosphate(PLP)-dependent enzyme lolC, to give the diamino diacid, NACPP (PubMed:15861432, PubMed:16755627).  Ensuing cyclization, decarboxylation, and acetylation steps yield 1-exo-acetamidopyrrolizidine (AcAP)(PubMed:24374065).  LolO is required for installation of the ether bridge upon the pathway intermediate, 1-exo-acetamidopyrrolizidine (AcAP) (PubMed:29537853).  In sequential 2-oxoglutarate- and O(2)-consuming steps, lolO removes hydrogens from C2 and C7 of AcAP to form both carbon-oxygen bonds in N-acetylnorloline (NANL), the precursor to all other lolines (PubMed:24374065, PubMed:29537853).  The enzymes lolD, lolE, lolF and lolT have also been proposed to be involved in the ether-bridge installation (PubMed:15654104).  Further processing of the exocyclic moiety of NANL by fungal N-acetamidase (LolN), methyltransferase (LolM), and cytochrome P450 (LolP) enzymes, with occasional involvement of a plant acetyltransferase, generates the other known lolines (PubMed:25531527, PubMed:18655839).  LolN transforms NANL to norlonine which is monomethylated and dimethylated to respectively lonine and N-methyllonine (NML) by lolM (PubMed:25531527).  LolP catalyzes hydroxylation of the methyl group in N-methylloline (NML) and further oxygenation to N-formylloline (NFL) (PubMed:18655839).  A plant acetyltransferase is responsible for the acetylation of loline to form N-acetylloline (NAL) (PubMed:25531527).  LolA might interact with aspartate kinase to prevent feedback inhibition of its activity by these end products and thereby promote production of l-homoserine from l-aspartate (PubMed:15654104).
What are the official names of this protein?
FAD-binding monooxygenase lolF2, Loline biosynthesis cluster 2 protein F.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: MUTL_PSEAE
Sequence: MSEAPRIQLLSPRLANQIAAGEVVERPASVAKELLENSLDAGSRRIDVEVEQGGIKLLRVRDDGRGIPADDLPLALARHATSKIRELEDLERVMSLGFRGEALASISSVARLTMTSRTADAGEAWQVETEGRDMQPRVQPAAHPVGTSVEVRDLFFNTPARRKFLRAEKTEFDHLQEVIKRLALARFDVAFHLRHNGKTIFALHEARDELARARRVGAVCGQAFLEQALPIEVERNGLHLWGWVGLPTFSRSQPDLQYFYVNGRMVRDKLVAHAVRQAYRDVLYNGRHPTFVLFFEVDPAVVDVNVHPTKHEVRFRDSRMVHDFLYGTLHRALGEVRPDDQLAPPGATSLTEPRPTGAAAGEFGPQGEMRLAESVLESPAARVGWSGGSSASGGSSGYSAYTRPEAPPSLAEAGGAYKAYFAPLPAGEAPAALPESAQDIPPLGYALAQLKGIYILAENAHGLVLVDMHAAHERITYERLKVAMASEGLRGQPLLVPESIAVSEREADCAEEHSSWFQRLGFELQRLGPESLAIRQIPALLKQAEATQLVRDVIADLLEYGTSDRIQAHLNELLGTMACHGAVRANRRLTLPEMNALLRDMEITERSGQCNHGRPTWTQLGLDELDKLFLRGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: FIXA_ECO55
Sequence: MKIITCYKCVPDEQDIAVNNADGSLDFSKADAKISQYDLNAIEAACQLKQQAAEAQVTALSVGGKALTNAKGRKDVLSRGPDELIVVIDDQFEQALPQQTASALAAAAQKAGFDLILCGDGSSDLYAQQVGLLVGEILNIPAVNGVSKIISLTADTLTVERELEDETETLSIPLPAVVAVSTDINSPQIPSMKAILGAAKKPVQVWSAADIGFNAVDAWSEQQVAAPKQRERQRIVIEGDGEEQIAAFAENLRKVI
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixA.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: SYH_WOLPM
Sequence: MTNQTVRGTKDLLFDEWYKFKYIEQTANRISSLYGFLPAQTPIFECTEVFTKTLGDSSDIITKEMYSFNDKGGKSITLRPEFTAAIVRLLIEKKLQTPIKLFSTGPAFRYERPQKGRQRQFHQINFEVFGIEDPKADIELISLAQHLLTEFGINKNVKLEINSLGDGETITKYREALILYFTKYQNDLSEDSKNRLIKNPLRILDSKDEKDKSIISDAPKISNYYTKESSDFFEQILNGLTILDIPYTVNNKLVRGLDYYCHTVFEFVTEDLGAQGAVFAGGRYDNLVSSVGGKHTPAIGFAGGIERIMELINYSPKEERPIYLIPIGREAEKHALTLANELRRNGLYVIYEYSGTLRTRMKKANQANAKAALIFGDEELSSKTLKIKNMDTGEEKIIARDNTIENIY
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYCC_GEOSL
Sequence: MSRKVTKYSAVLAVSLFAAALAGCGSENKEGTVGTGPGGVATVGDTACVQCHSAVVDPLTGESIITQYTRSFHYSKGVGCEGCHGGGAQHNGVGPLPFPLAGQSEAQIAARCASCHNGVIAPLSSSPNFVNGNHANPFGGEEAKENLCSRCHSHEGAIFGAQAGFTGDGNILRNAAYQPVYPQDPETFNVMTCATCHQHGGAQRQVFTQISTAGVPNSRRTVAWDPNRNSINDQYDLCTSCHTVNTMTGTLIGSGNVLQIFTSNAVGSGTKSVTTAPFYHNTRWFRTLPSTHYDFPESKTTASGTTIEGYVIRRNTANPCFDCHGHEFQTNTRRLAGADRPNTIFLDWGQSAHGGKLLQAKVAAAALASSGAAEVDDVMKAGATDATAPGWTHYNWDDTASRGACQRCHTSTGASNFLNNPAGYDRTGAGNSFTHLAGWTSSNKRSDQNELLYCWGCHTKAGTGELRNPGAITEVYPGINSTSTGTTGLDVTVSYPDIKGSNVCMGCHLGREVGDNIKAITDADGILGFVNSHYLTAGGQLFGTTGYEYATRSYANPAFFQHDKIGTAAAPGTGTNGPCAGCHMTTPTSHLFLPVTKDGTGAITAITSTACVTCHAGTFALTPEGLTAEEEEYVASLEALKAALAGKGILFFNAHPYFYRDTNANGIADPGETVSSNAFTNWAGVYGLALWQDVMGAAFNANLLIHDPGGYAHNRFYSKRLIWDSIDFIFDGVLNNDVTAAIDAQVTAARLDSATATAAKAYLGATRP
What is the function of this protein?
Not involved in Fe(3+) reduction.
What are the official names of this protein?
C-type polyheme cytochrome OmcC, Outer membrane c-type cytochrome C, Polyheme membrane-associated cytochrome c.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.