PharMolix/UniProtQA huggingface dataset:
Protein: SYA_ANAMM
Sequence: MSSGSLSSIRKKFLEFFVKNGHKLYASAPLVATGDASLLFTSAGMVPFKQAFTSGSSVDGAKTAVSSQKCLRAGGKHNDLENVGYTNRHHTFFEMLGNFSFGDYFKERAIELAWRFVTEEMCLSKDRLWITVYSEDQEAFDIWKKITGFPDDRIIKISTSDNFWSMGDTGPCGPCSEIFYDYGEHVQGGPPGSKDADGPRFTEVWNLVFMQFCRDEHGELNPLPHKCIDTGMGLERAAAVVQGVCDNYDTDLFKAVIRKSQDVFGSPDNSIAHRVIADHIRAAAFLISEGLSPGNEGRNYVLRRIIRRAVRYAYQLDPSNVAIHEVLPVLTKEGSAGYMGDAYPELVRCEQSITSTLRSEGEGFVDTLRRGMALLEKEIGGLSPGQVLLGDVAFKLYDTFGFPLDITLDIAKERGLKFDQEGFNKGMGEQKARSRKHWVGSGEDASHRLWEELQAQHKNTRFVGYDCCSTKASVLSITRDGMAVQSVNSGEKACLLLDVSPFYAESGGQEGDKGSITGVSGVKNSGGANIAEVTYTRKASNLHIHECTITSGVFNVGDTVDAAIDVDRRERLKANHSATHILHSVLRTHIDGNIQQKGSLVAEDKLRFDFNYASALTKEQIALIEREVNRRIMSNKPVLTDHCSFEAAVQGGAIALFGEKYSEHSVRVVSMGDSKELCGGTHVRYTGDIGAFKIVSESGIALGVRRIEAITGQSVVDGLRKDGDILLHISERLGVPVGEVSEGLERLLKEKLELKKKLVCAWHEIIKSSISPVNCGAGVVLHCGYFPTIPVDAIMEFMKSARKAERGIFAIATAVDGKAVLIIGVGDTASKVLGASELVKTLADLQGKGGGNAGLARVSLEVGNVQEALSTILNKVTAAFPT
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HARC1_ARATH
Sequence: MYTYSLLNLSHCRRQTRKKRKTDHTEGFLMEETKPKTVEDVETVDVYTAKGFLSTGHRYLDVRTNEEFAKSHVEEALNIPYMFKTDEGRVINPDFLSQVASVCKKDEHLIVACNAGGRGSRACVDLLNEGYDHVANMGGGYSAWVDAGFAGDKPPEDLKIACKFRPKEN
What is the function of this protein?
Arsenate reductase critical for arsenic tolerance (PubMed:25099865).  Reduces arsenate to arsenite in the root, facilitating efflux of arsenic back into the soil to limit both its accumulation in the root and transport to the shoot (PubMed:25464340).  Essential for arsenite efflux from the root, but not necessary for arsenate uptake (PubMed:25464340).
What are the official names of this protein?
Protein HIGH ARSENIC CONTENT 1, mitochondrial, AtHAC1, Arsenate reductase, Arsenate tolerance QTL1, AtATQ1, Rhodanese-like domain-containing protein 19, Sulfurtransferase 19, AtStr19.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1569_LISMF
Sequence: MLIHEISENEKPREKLQNYGIEALSSSELVALIIETGTKNESVLTIANRIIMKFKNVGEMQYASIEEFQLVNGIGIAKASKIMAAIELGRRIGIVTEQEEVVVRCPEDAVKLVMPELAFLFQEHFHCLFLNTKNQVIYRQTIFVGGLNASIVHPREVFRLALRKSAASIMCFHNHPSGDPTPSSEDLLVTKRLAEAGNIVGITLLDHIIIGKNKYISLKEKGYF
What are the official names of this protein?
UPF0758 protein LMOf2365_1569.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: GANAB_DICDI
Sequence: MRKLVILIILSIVCSLFIGSIESVDTSKFKTCKDSHFCKRNRVSHEVGVMNEMKSKQNFNIVEGSIKLVKQENTIYFDLQEQNQKSNLLTMKLEIYEGGIVRMRAQEKEPLLNKQRYQVQDVLLDTIKTVPIQWKQEPSKQSNTFSFKHGEKECCYVLVQLVPFKLDVYIMNELAITTNSDNLFHFEPISDKPQPLPPKEKKSEEENKEANQEEDNNNNNNDNNEEQQVSTEGYWEERFGSHQDSKPNGPMSIGMDFTFVGSSHVYGIPEHTTRLSLKSTTGNGINEQPYRLYNLDVFEYEIDKTMALYGHVPLMISHDTKKTVGVFWLNAAETFVDIEDVTTPVSPSKKTHWISESGIIDVFYLTGPTPSTIFKQYAYLTGTTALPQMFSLGYHQCKWNYKSEDDVKQVDNGFDENHIPYDVIWLDIEHTDGKRYFTWDNNNFPTPADMQNIIGAKHRKMVTIVDPHIKRDNNYYVHSEATSKGYYIKNKDGNDYDGWCWPGSSSYLDFTNPEIRKWWATQFGYDKYKGSTPNLYIWNDMNEPSVFNGPEVSMHKDAKHHGGFEHRDVHNLYGYYYHMASADGLVQRNADQNDRPFVLSRAFYAGSQRIGAIWTGDNSAQWSHLEISNPMLLSMNLAGITFSGADVGGFFGNPDAELLTRWYQAGAFQPFFRGHAHLDSRRREPWLFNEPYTTIIREAIVKRYSYLPLWYTTFYQNTLNGAPVMRPLWVQYPKEANLFDVDDHYLIGDSLLVKPVTQQSCKTMKVLLPGQSVNEIWYDVDTEKPINAGVIEIDTPLEKIPVYQRGGSIISKKERVRRSTYQMRDDPYTIRIALDSSKSAQGQLYIDDEHSFDYKKGKFLYRQFTFKDNVLSFSDASNKSSTSYKPNVTIEKIVILGVQKPHSITCNITGKEKLSFEYDSTLSKLTIRKPDLLVDTDFIIKLN
What is the function of this protein?
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from N-linked oligosaccharides on newly synthesized glycoproteins.
What are the official names of this protein?
Neutral alpha-glucosidase AB, Alpha-glucosidase 2, Glucosidase II subunit alpha, Protein post-translational modification mutant A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 31 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus.
Protein: TILS_MESH2
Sequence: MQIKIKSKEKYLIGVSGGSDSMFLLNKYKNQDVIVAHINYNLRPEAIFETLLVSKFCQKYNLELKILSFDSFKIKKNLQSGLRLGRYQFFEKIYKEFNCTKLLVGHHRDDFLETVFLQKKQKKIVTFWGIHKKNNLFNMEILRPFLYWRTKKQIIRICQQKKIPYLDDQSNFTGKYQRNQIRFLLEKKSDFSLFFLFLFYYLINIFKLIILKNQKKILQNWQKTGYNINFFKKIKIKSKIIFLFVNQNFDNVKLTRGKINEIINFICGKSTSGAFLLKKNNYIIKKKWKILPKSSKI
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAP1_CAEEL
Sequence: MPAFFCLPMACQRQVDSIDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVLPAEIGNLTQLIELNLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITILSLNETSLTLLPSNIGSLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEIGKLTSLREFYVDINSLTSLPDSISGCRMLDQLDVSENQIIRLPENLGRMPNLTDLNISINEIIELPSSFGELKRLQMLKADRNSLHNLTSEIGKCQSLTELYLGQNFLTDLPDTIGDLRQLTTLNVDCNNLSDIPDTIGNCKSLTVLSLRQNILTELPMTIGKCENLTVLDVASNKLPHLPFTVKVLYKLQALWLSENQTQSILKLSETRDDRKGIKVVTCYLLPQVDAIDGEGRSGSAQHNTDRGAFLGGPKVHFHDQADTTFEENKEAEIHLGNFERHNTPHPKTPKHKKGSIDGHMLPHEIDQPRQLSLVSNHRTSTSSFGESSNSINRDLADIRAQNGVREATLSPEREERMATSLSSLSNLAAGTQNMHTIRIQKDDTGKLGLSFAGGTSNDPAPNSNGDSGLFVTKVTPGSAAYRCGLREGDKLIRANDVNMINASQDNAMEAIKKRETVELVVLRRSPSPVSRTSEPSLNGSSHQLNHFDAGSPDSTMFVTSSTPVYAS
What is the function of this protein?
Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells.  Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells.  Required for correct localization of ifb-2 intermediate filaments in the terminal web.  Required for dlg-1 lateral localization (PubMed:18411252).  With dlg-1, cooperatively regulates ajm-1 localization to apical junctions (PubMed:11715019).
What are the official names of this protein?
Protein lap1, Lethal protein 413.
What is the protein family that this protein belongs to?
Belongs to the LAP (LRR and PDZ) protein family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Peripheral membrane protein. Note=Basolateral membrane of epithelial cells.
Protein: HEM3_BRUME
Sequence: MQTASFKNGTLKIGTRGSKLALAQAYLTRRLLQEAHGLPEDAIEILPMSTAGDRIQDRPLSEVGGKGLFTEEIEQALKDGRIDIAVHSTKDMPTALPEGLHLSVFLEREDPRDAFIGRSARRFMDLPQGATVGSSSLRRQALIRRLRPDIEVVMYRGNVDTRLRKLDAGEVDGTFLACAGLRRLGLADVITDVLDPSVFPPAPGQGAIGIESRIGDERIDVLLAPLAHRETQIALACERAFLGALDGSCRTPIAGLATVEGDRLSFRGMILTPDGRQAHEVTAEGVVSDAAALGTDAANRVRAMAGPHFFDGWQ
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: TPPC2_RAT
Sequence: MSGSFYFVIVGHHDNPVFEMEFLPAGKTESKDEHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRLIMLHDVRQEDGIKNFFTDVYDLYIKFAMNPFYEPNSPIRSTAFERKVQFLGKKHLLS
What is the function of this protein?
Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death.  May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
What are the official names of this protein?
Trafficking protein particle complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. Sedlin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm. Note=Localized in perinuclear granular structures.
Protein: LGT_ACTPJ
Sequence: MNEQFIQFPQIDPIIFSIGPIALRWYGLMYLIGFGFAYWLGMRRAKNSNGVWTTEQVDQLIYTCFWGVILGGRIGDVFFYNFDRLLQDPMFLFRIWEGGMSFHGGLIGVIVAMIWVSFRQKRSFWNTADFIAPLIPFGLGMGRIGNFINDELWGRITDVPWAVLFPSGGYLPRHPSQLYEFFLEGVVLFFILNWFIKKPRPAGSVAGLFLIGYGVFRFLVEYVRDIDPNVNTVDDLITRGQLLSLPMIIGGLAIMIWAYSRKKA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OB59A_DROME
Sequence: MKQLIFLLICLSCGTCSIYALKCRSQEGLSEAELKRTVRNCMHRQDEDEDRGRGGQGRQGNGYEYGYGMDHDQEEQDRNPGNRGGYGNRRQRGLRQSDGRNHTSNDGGQCVAQCFFEEMNMVDGNGMPDRRKVSYLLTKDLRDRELRNFFTDTVQQCFRYLESNGRGRHHKCSAARELVKCMSEYAKAQCEDWEEHGNMLFN
What is the function of this protein?
Odorant-binding protein required for hygrotaxis behavior in humidity-detecting sensilla.
What are the official names of this protein?
Odorant-binding protein 59a.
What is the protein family that this protein belongs to?
Belongs to the PBP/GOBP family.
What are the subcellular locations of this protein?
Secreted.
Protein: MSBA_BURMA
Sequence: MSVKPTLSKPIGGQDASSPAVVMRRLWPYVKPLVWVLVAGVLAMAAVAATEAGIPALLKPLLDHGFGSKGDMTTKLYVPAAVVGLALARAIAQYASGYLLQYVSNRILLDLRIQMFERMIHTGVSFFQRETASTVINAVVFEVNQVLSVLMGVTITLVRDSLTVVFLLGYLFYLNWRLTLIVAILLPCIGWLVGKINRRLRRLNREHQTLTNQLAYIVEETVGGYKVVKVHNGEPYEIGRFNELSRKLRGYSMRMTVSGGLAQPLTQFLASIALAVVLTIAVVQSANDQTTVGGFVAFVTAMLLIISPLKHLMDVNQPLQRGMTAAELIFGLIDEPREPEGGGKPLARASGAIEFSHVSFSYGMSRDGRQTLDDVSFTVAPGEMVALAGPSGSGKTTLVNLLPRFFDPSSGSVRVDGVALPEYSLRDLRNQIAMVSQDVVLFNDTIAANVAYGQAPERDRVEAALRAANLWETVTAMPDGIDTLVGDNGMRLSGGQRQRLAIARAIYKDAPILILDEATSALDSESERHVQAALETLMKGRTTLVIAHRLSTIERADRILVLEGGKIVESGSHRELLEQGGLYAHLHRIQFQQDAG
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SIL1_CANAL
Sequence: MKFSVLVLLASYLVGVNSSIVDTSEELICPDPENPLDCYPKLFVPTNEWQTIKPGQDIPPGLHVRLNIDTLEKEAKLMSADEKDEPVQEVVVGGELQDHSREAITENLQKLHESKHPEVKQEHAHRTKVSQGDLSNFDAACSEIESFKPHESDVERLHLALDTLEELSHDIEFGVKLTSDKAIFQSLVNIANGASDPKITEKVYRVMGSSLRNNPEAISNILTNFDKSYVDNLFEQLANENDVLQKRILGIIQALVQNSHFVRQYFSFDHSSGLNDLIAIFPKLGPNSKSRASNILEDLQLFPVTNDRRSLEDQDPESQVSKFIQNSFVGNKLDEKNFKSYFDQLVNLHQSNKSLRPSGDFLNWLAEEVESRKENKKRDDYSQEDKDFDEYMLRARHEVFGNPMGLRKAIADEL
What is the function of this protein?
Required for protein translocation and folding in the endoplasmic reticulum (ER).  Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).
What are the official names of this protein?
Nucleotide exchange factor SIL1.
What is the protein family that this protein belongs to?
Belongs to the SIL1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RL14_BRASO
Sequence: MIQMQTNLDVADNSGARRVMCIKVLGGSKRRYATVGDIIVVSIKEAIPRGKVKKGDVMKAVVVRVRKDIRRADGSVIRFDRNAAVLINNQSEPVGTRIFGPVPRELRAKNHMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SECA_PROMA
Sequence: MLKLLLGDPNARKLKRYQPILTDINLFEDEIASLNDDELRGKTSDFRTRLDKSSDSSIQECLDDLLPEAFAVVREASKRVLGMRHFDVQLIGGMVLHEGQIAEMKTGEGKTLVATLPSFLNALTGRGVHIVTVNDYLARRDAEWMGQVHRFLGLSVGLIQQDMTPIERRKNYECDITYATNSELGFDYLRDNMANDINEIVQRDFQFCIIDEVDSILIDEARTPLIISGQIERPQEKYQKAAEVVSTLQRAAEMGKDGIDPEGDYEVDEKQRTCTLTDEGFAKSEELLKVKDLFDPKDPWAHYITNALKAKELFVKDVNYIVRNEDAVIVDEFTGRVMPGRRWSDGQHQAIEAKEELPIQPETQTLASITYQNFFLLYPRLAGMTGTAKTEEVEFEKTYKLETTVIPTNRPRSRADWVDQVFKTESAKWRAVANETVEIHKKGRPVLVGTTSVEKSEVLSALLGEQDVPHNLLNAKPENVEREAEIIAQAGRAGAVTIATNMAGRGTDIILGGNSDYMARLKVREVLFPKLVKPEDSHKPPVPLQRRKDSSVGFGKEENNSKDKKVNHSNDVRAQENLYPCVLTDSTEQVLLDLEHQLIKEWGDRVLSPIELEDRISTAAEKAPTQDPLVQSLREAISLVKSEYDVVVKQEEVHVREAGGLHVIGTERHESRRVDNQLRGRAGRQGDLGSTRFFLSLGDNLLRIFGGDRVAALMNAFRVDEDMPIESGMLTRSLESAQKKVETYYFDIRKQVFEYDEVMNNQRRAVYSERHRVLEGDELKKQVIGYGERTMQEIVYAYVNPELPSEEWDLKQLVGKVKEFVYLLDDLKPKDIEALNIDELQAFLQEQLRNAYDLKESQIEESRPGLMREAERFFILQQIDTLWREHLQSMDALRESVGLRGYGQKDPLIEYKNEGYDMFLEMMTNMRRNVIYSMFMFQPAPPSDKE
What is the function of this protein?
Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: RK16_EUGGR
Sequence: MLSPKRTKFRKYHRGRLTGKIYLIDKVVFGNYALQSLEPGWITSRQIEAARRVITRYAKRGGKLWIRIFPDKPVTFRAAETRMGSRKGNVEYWVAIVKPGKILYEVLGISESIAKYSLKIAGYKMPIKTRVIVKI
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AROD_STRPD
Sequence: MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFTLRTVQEGGNITLSSQEYVDIIKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNFEETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNYTRGFKTLNPEQEFATISMGKLGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: QUEF_ACIAC
Sequence: MNTPDQSQLGRVSGYADQYDASLLFPLPRQPKRHEIGVTGTPPFFGADLWTAFELSWLNLRGKPQVALAHITVPCETPNIIESKSFKLYLNSFNNTRFADAAQVQTRIRTDISEAAWRGSDRQATVGVKLVLPEMFDREPVQELDGLLLDRLDVECTHYTPAPELLHANHGEAPVTETLTSHLLKSNCLVTGQPDWGSVRIEYSGAQIDQSGLLRYLVSFRNHNEFHEQCVERIFMDLWTRCRPIKLSVYARYTRRGGLDINPLRTSHPQALPANVRTARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_BURCM
Sequence: MAKTLSKPASGALAPWLGISLIVILFDQLSKIAILKTFAYGAQHALTSFFSLVLVYNRGAAFGFLSTASGWQRWAFTALGIGATLVICFLLRRHGQQRLFSLSLALILGGALGNVIDRLVYGHVIDFLDFHVGGWHFPAFNLADSAITIGAVLLVYDELRRVRGSR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TOP6A_PYRAB
Sequence: MKLKRQKPKEKFSYDPQKVLKKLEDLAWKILEEVKSGKNPYFDVPTRGLNNVYFDEEARLIKLGDKLSRRYFLNVAHARKFTQTLILMAYIKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERMLGVLREEMHITADRRGYIYGDIVIKDGEDEFNASKLGTGGWAVPGTVEHIQFPEVNVDYVLVVETAAMADRLIEEKYPKKENCLIVATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYNLEHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP
What is the function of this protein?
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit A, Type II DNA topoisomerase VI subunit A.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
Protein: PNP_SHESW
Sequence: MNPIVKSFEYGQHTVTLETGVIARQADAAVLASMGDTTVLVTVVGKKEAEAGRDFFPLTVNYQEKTYAAGKIPGGFFKREGRPSEDETLIARLIDRPIRPLFPNGFKNEVQVIITVVSVDPQIEPDIISMIGTSAALAISGIPFSGPLGAARVGYINGEYVLNPTVAQIETSQLNLVVAGTASAVLMVESEAQALPEEVMLGSVVYGHDQQQVVINAIAEFKAEAGKPMWDWTAPVQDETLVAQIKELAEAGLGDAYKIQVKQDRYAQVAVVKAATKEALLASNPNIDLREVDNLLGSLEKKVVRGRIIRGEPRIDGREPDMIRALSVLAGVLPRTHGSALFTRGETQALVTCTLGTERDAQKIDSIMGERTNRFMLHYNFPPYSVGETGMVGSPKRREIGHGKLAWRGINAVMPSAEEFPYSVRVVSEITESNGSSSMASVCGTSLALMDAGVPIKTSVAGIAMGLVKEGDDFVVLSDILGDEDHLGDMDFKVAGTRGGITALQMDIKIEGITKEIMEIALQQAYGARVHILNVMDQAIGSHRDDISDHAPRITTIKINPEKIRDVIGKGGAVIRALTEETGTTIELEDDGTVRIASSNGEATKEAIRRIEEITSEVEVGRIYNGKVIRIVDFGAFVNILPGKDGLVHISQISDERVANVSDHLELNQEVAVKVMEVDRQGRVRLSIKEAQTKEAAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCAR_ECOUT
Sequence: MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS
What are the official names of this protein?
UPF0434 protein YcaR.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: CP1A2_RAT
Sequence: MAFSQYISLAPELLLATAIFCLVFWVLRGTRTQVPKGLKSPPGPWGLPFIGHMLTLGKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLITNGKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSVSSCYLEEHVSKEANHLISKFQKLMAEVGHFEPVNQVVESVANVIGAMCFGKNFPRKSEEMLNLVKSSKDFVENVTSGNAVDFFPVLRYLPNPALKRFKNFNDNFVLFLQKTVQEHYQDFNKNSIQDITGALFKHSENYKDNGGLIPQEKIVNIVNDIFGAGFETVTTAIFWSILLLVTEPKVQRKIHEELDTVIGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPFTIPHSTTRDTSLNGFHIPKECCIFINQWQVNHDEKQWKDPFVFRPERFLTNDNTAIDKTLSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLHQLEFTVPPGVKVDLTPSYGLTMKPRTCEHVQAWPRFSK
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2.  Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis.  May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver.  Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid.  Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer.  Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA.  May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).  Plays a role in the oxidative metabolism of xenobiotics.  Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.  Metabolizes caffeine via N3-demethylation.
What are the official names of this protein?
Cytochrome P450 1A2, CYPIA2, Cholesterol 25-hydroxylase, Cytochrome P-448, Cytochrome P-450d, Cytochrome P450-D, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.