PharMolix/UniProtQA huggingface dataset:
Protein: PA2B_BUNMU
Sequence: FLLGAANIPPHPLNLINFMEMIRYTIPCEKTWGEYADYGCYCGAGGSGRPIDALDRCCYVHDNCYGDAANIRDCNPKTQSYSYKLTKRTIICYGAAGTCARIVCDCDRTAALCFGNSEYIERHKNIDTKRHCR
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
What are the official names of this protein?
Basic phospholipase A2 beta-bungarotoxin A-AL2 chain, Beta-BuTX A-AL2 chain, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: F16PA_PECAS
Sequence: MKTLGEFIVEKQHDFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGISNVQGEVQMKLDLYANEKLKAALKARGEVAGIASEEEDEIVIFEGDKAENAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRITPLGTSVTEADFLQPGSQQVAAGYIVYGSSTMLVYTTGHGVHAFTYDPSLGVFCLSHEKVCFPEKGNMYSINEGNYIKFPSGVKKYIKYCQEQDEETQRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASYPKGKLRLLYECNPMAFLAEQAGGKASDGKHRILDITPEKLHQRSPFFVGTESMVDDVERFIREFPDA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_ACTP7
Sequence: MKTLGEFIIEKQAEYPEAKGELSGILSSIRLAAKIIHREINRAGLSQDILGVAGSENIQGEAQMKLDVFANETMKKALLAREEVAGFASEEDDNFVAFENDRAKNAKYILMTDPLDGSSNIDVNVSVGTIFSIYKRVSPIGSPVTMEDFLQEGRKQVASGYVTYGSSTMLVYTTGNGVNGFTYDPSLGLFILSHPDMKMPTEGKYYSINEGQYVTFPMGVKKFIKYCQESDEATKRPYSSRYIGSLVSDFHRNLLKGGIYIYPTSTVYPKGKLRLLYEGNPMAFLAEQAGGMATDGFNPILDIKPSELHQRVPFFVGSTSMVKQADKFMQECAE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBK_GIAIN
Sequence: MSAGKTVVIALGGNAMLQAKEKGDYDTQRKNVEIAASEIYKIHKAGYKVVLTSGNAPQVGAIKLQNQAAAGVSPEMPLHVCGAMSQGFIGYMMSQAMDNVFCANNEPANCVTCVTQTLVDPKDQAFTNPTKPRWRFYTEQEAKDLMAANPGKILREDAWPAGWRVVVPSPRPLEIVEYGVIKTLIDNNVLVICTNGGGIPCKRENKVISGVDAVIDKDLATSLLAKTLNSDYLMILTDVLNACINYKKPDERKLEEIKLSEILALEKDGHFAAGSMGPKVRAAIEFTQATGKMSIITSLSTAVDALNGKCGTRIIKD
What are the official names of this protein?
Carbamate kinase.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
Protein: TOT2B_ATRIL
Sequence: MKFSKLSITLAVILTQAVFVLCGMKNEDFMEKGLESNELHDAIKKPVNSGKPDTERLLDCVLSRVCSSDANCCGLTPTCKMGLCVPKVGGLLGGLLGGIL
What is the function of this protein?
Potent inhibitor of insect, but not mammalian, voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-hexatoxin-Asp2b, Omega-HXTX-Asp2b, Omega-atracotoxin-As2b, Omega-AcTx-As2b.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 15 family. 02 (omega-actx) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MDTI_SHISS
Sequence: MAQFEWVHAAWLALAIVLEIVANVFLKFSDGFRRKIFGLLSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRKGWIGLVLLLAGMIMVKLA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtI.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNZ_PROM9
Sequence: MNITFLGTSSGVPSLTRNVSSLALKLSQSSEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGLSGNSNGIEIYGPLGLRSFISSALSSSFCKLSFPLHFVEVENFASENKILFENNKLKVNCACLKHKIPAYGYRVSEKDKPGIFDIKKAESMKIAPGPIYSKLQQGKEVLLPDGRTVNGKEFCGPPRKGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQEDESMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTSKNSITPSDLLKEAQKVFPNTHLAKDFLVADIK
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: ENGB_HELAH
Sequence: MIIIKDAHFITSSSQLSQCPASLTSEMVVLGRSNVGKSSFINTLLGKNLAKSSSTPGKTRLANFFSTTWEDKKNALTTTFSVIDLPGFGYAKVSKSLKKEWEGFLWELLSVRTSIKLFIHLIDARHLNLEIDKNAKENIQTLLRSDQAYLSLFTKFDKLNKNEQHRLFLNAPKPFLINTTHFNALSSKYPTLEIVRQTLLKYLLTNPL
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: SPEE_ESCF3
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKDVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSNYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSSEIIQARFLASGLKCRYYNPAVHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLM1_PLAF7
Sequence: MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDNVLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKPHLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
What is the function of this protein?
During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain.  Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity.
What are the official names of this protein?
Plasmepsin I, Aspartic hemoglobinase I, Plasmepsin 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Membrane; Single- pass type II membrane protein. Vacuole lumen. Vacuole membrane. Note=At the beginning of the asexual blood stage, the transmembrane zymogen is transported to the cytostome, an endocytic structure spanning the parasite cell membrane and the parasitophorous vacuole membrane where host proteins such as hemoglobin are endocytosed. Following endocytosis, localizes to the cytostome vacuole membrane to be then delivered to the digestive (or food) vacuole where it is cleaved into the soluble and active enzyme. In trophozoites, localizes to the digestive vacuole, an acidic vacuole where host hemoglobin is digested.
Protein: PSBL_WELMI
Sequence: MTQTNPNEQSVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CDSA_CHLTR
Sequence: MFDSDHNSIFQSDLCQRLVVHSILLTFLVILLCTSLYPSSAFIVGLLSSACAALGTYEMGAMVRIKFPFSFTRYSALGSAIFIALTCLTARCKMCFPEHIDLLPWFFLFFWTIRLVFKSRHYKLGPIGSTGLALFCMLYVSVPIRLFLHILYGFVHTDTPFVGIWWAIFLIATTKSSDIFGYFFGKAFGKKRIAPVISPNKTVVGFIAGCCGSILVSLLFYSHLPKAFADQIAVPWILIALGTVLGVSGFFGDIIESTFKRDAQIKNSSDLESIGGMLDVLDSLLLSTPIVYAILLITQNRTFLG
What are the official names of this protein?
Phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SCX1_TITOB
Sequence: MTRFVLFISCFFLIDMIVECKKEGYLVGNDGCKYGCITRPHQYCVHECELKKGTDGYCAYWLACYCYNMPDWVKTWSSATNKCKGK
What is the function of this protein?
Beta toxin that show multiple effects.  It enhances the open probability at more negative potentials of human Nav1. 3/SCN3A and Nav1. 6/SCN8A, of the insect channel BgNaV1 and of arachnid VdNaV1 channel (PubMed:30463697).  It promotes an important shift in slow inactivation processes as a function of the prepulse voltage in human Nav1. 3/SCN3A and Nav1. 6/SCN8A and a small shift in Nav1. 1/SCN1A, Nav1. 2/SCN2A and Nav1. 4/SCN4A (PubMed:30463697).  Finally, it reduces the peak of sodium currents in Nav1. 3/SCN3A (80% inhibition at 70 nM of toxin), Nav1. 6/SCN8A (55. 3%), Nav1. 1/SCN1A (53. 3%), Nav1. 5/SCN5A (46. 7%), Nav1. 2/SCN2A (42. 7%) and Nav1. 4/SCN4A (20%) voltage-gated sodium channels (PubMed:30463697).  It has also been shown to affect the sodium current permeability of rat cerebellum granular cells in a partially reversible manner (PubMed:11821128).  In vivo, an intraperitoneal injection (20 ug) into mice produces excitability, respiratory problems, convulsions and death, within the first 30 minutes after injection (PubMed:11821128).
What are the official names of this protein?
Beta-mammal/insect toxin To1, NaTx12.1, Toxin Tc49b.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGI_BACCD
Sequence: MKPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERLHYDIEDLGDIPIGKAERLHEQGDSRLRNLKAVAEANEKLAAAVDQVVQRGRFPLVLGGDHSIAIGTLAGVAKHYERLGVIWYDAHGDVNTAETSPSGNIHGMPLAASLGFGHPALTQIGGYSPKIKPEHVVLIGVRSLDEGEKKFIREKGIKIYTMHEVDRLGMTRVMEETIAYLKERTDGVHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLAEAQIITSAEFVEVNPILDERNKTASVAVALMGSLFGEKLM
What is the function of this protein?
Controls arginine catabolism.
What are the official names of this protein?
Arginase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: ECOT3_LEIMA
Sequence: MPSLQDYHVPYPAAAPGQVRKVIYLPRQNPTVEQQHLRVQIIPGRHENCDDGRLYKLTGSVTEETLQGWGYSYYVVTLGDIYAAHRSSSDPARATTFVALDESPVIAYNSKLPIVVYVPEGAELRYRIWTDDASLAQSIQQKPEAPALPQPHLVPVTEGQECPQELPRCGAPSEYVRQDYKASMLSVEEVHRLSNNTPPLIPSAVHESAHEAHAAPPLHSAVLEEHGRPGMEHLEVCPKNNGSEGREQPAEEASTLKQRSSSSSSNPRHHSANESSPSRPRLSSTAYWPQENSKTKRSPSATHKPRRSTDSAAIEETGVGTPKKNRSSSGSASNKRKAEDDVYEKTMKNFWNRARSDSPRKASASSTKSGNGSKADPVDGK
What are the official names of this protein?
Ecotin-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
Protein: PER15_IPOBA
Sequence: MASFSPLLAMALAIFIFSSHSNAQLSSTFYSTTCPNVSAIVRTVVQQALQNDARIGGSLIRLHFHDCFVDGCDGSLLLDNNGTTIVSEKDALPNTNSTRGFDVVDNIKTAVENACPGVVSCVDILALASESSVSLAGGPSWNVLLGRRDRRTANQGGANTSLPSPFENLTNLTQKFTNVGLNVNDLVALSGAHTFGRAQCRTFSPRLFNFSNTGNPDPTLNTTYLATLQQICPQGGSGFTVTNLDPTTPDTFDNNYFSNLQTNRGLLQSDQELFSTSGAPTIAIVNNFSANQTAFFESFVQSMINMGNISPLTGSNGEIRSNCRRPN
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 15, Prx15, Anionic peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GPMA_GLOC7
Sequence: MSKLILIRHGQSLWNAANKFTGWVDIPLSRRGRAEAMIAASKLQEQGYRIDVCFTSLLIRAMETAIIALTEYEQLCGGKTPIFKHDADDLDWHGWDKYDGDPKEELPIFPSQALDERYYGDLQGLNKAQTAQKYGSEQVHEWRRSYFTRPPGGESLEDTQKRVIPYFENRILTHIAHGDTVMVAAHGNSLRAMIMRLENLQPEDVPNLELATGIPLIYEVDQQAKVSNKIVLH
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: URED_BORPE
Sequence: MSETLDQWRAGLTLGFAPGHAGRTVLRERAHYGPMLVQRALYPEGPQVCHVAILHPPSGIAGGDALEIRVDVAGGARAALTTPGATRWYKSNGRQASQDVHLRVAAGGRLDWLPLESIFFEEADALARNRIQLESGAAAIGWDLIQLGRVNQSGHWSQGRLHTATELYVDGRLLWVDQGLVGAQDDVRRQVSGLAGFPVHAALWSFGPRLDAEQNEELAGLMPWSDTLRGAATTMPYDATQSLCLVRCLGVHMEDVRAVMTDAWAYLRPRVLDTPAVVPRLWAT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH2_CORJK
Sequence: MAVSFLQSLFSVFRKKSSPQEPATTTAGGPAKRTKLTVGELQEFAPEWIVIGLGNPGAKYADTRHNIGYWPIDRLVERYEAQWLPVEGQKAHAALITVEETPVLLLRSTTYMNNSGEAVGPLASALSLPAERIIVCHDELDIAAGQVRIKDKGGEGGHNGLRSMTAELGTQHYVRVRMGIGRPPKGTSVIDFVLSPFEEADIDAENGWMENTLRDSVDSVTLIVNNGTDIARNDIHTRKH
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase 2, PTH 2.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_STACT
Sequence: MIQTEEMNQLKADALADISQAADEKALQDVKVKYLGKKGSVSGLMKQMKDLSNEEKPKFGQAVNEVRQAIESAIADRKSVLEQDRLNKQLEEETIDVTLPSRSIKLGATHPLTRTIQEIEDLFLGLGFEIVNGYEVEQDYYNFEALNLPKSHPARDMQDTFYITEETLLRTHTSPVQARTLEKRNGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVAENIKMSDLKGTLELVAKKLFGEEREIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKQTGWIEILGAGMVHPNVLEMAGFDSSKYTGFAFGMGPDRIAMLKYGIEDIRYFYTNDVRFLDQFKAVEDRGEA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSMA2_STAAM
Sequence: MGIIAGIIKFIKGLIEKFTGK
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
What are the official names of this protein?
Phenol-soluble modulin alpha 2 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: P66B_HUMAN
Sequence: MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLKRKDLANLEVPHELPTKQDGSGVKGYEEKLNGNLRPHGDNRTAGRPGKENINDEPVDMSARRSEPERGRLTPSPDIIVLSDNEASSPRSSSRMEERLKAANLEMFKGKGIEERQQLIKQLRDELRLEEARLVLLKKLRQSQLQKENVVQKTPVVQNAASIVQPSPAHVGQQGLSKLPSRPGAQGVEPQNLRTLQGHSVIRSATNTTLPHMLMSQRVIAPNPAQLQGQRGPPKPGLVRTTTPNMNPAINYQPQSSSSVPCQRTTSSAIYMNLASHIQPGTVNRVSSPLPSPSAMTDAANSQAAAKLALRKQLEKTLLEIPPPKPPAPLLHFLPSAANSEFIYMVGLEEVVQSVIDSQGKSCASLLRVEPFVCAQCRTDFTPHWKQEKNGKILCEQCMTSNQKKALKAEHTNRLKNAFVKALQQEQEIEQRLQQQAALSPTTAPAVSSVSKQETIMRHHTLRQAPQPQSSLQRGIPTSARSMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHKGPSLADRQREYLLDMIPPRSISQSISGQK
What is the function of this protein?
Transcriptional repressor (PubMed:12183469, PubMed:16415179).  Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666).  Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179).  Efficient repression requires the presence of GATAD2A (PubMed:16415179).  Targets MBD3 to discrete loci in the nucleus (PubMed:11756549).  May play a role in synapse development (PubMed:23644463).
What are the official names of this protein?
Transcriptional repressor p66-beta, GATA zinc finger domain-containing protein 2B, p66/p68.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Speckled nuclear localization requires both CR1 and CR2 regions.
Protein: FMT_BURCH
Sequence: MTHTLRVIFAGTPEFAAAALAAIHKAGFPVPLVLTQPDRPAGRGMKLQASAVKRYAVEHGMAVAQPPSLRRAGKYPAEAADAIELLRTTPHDVMVVAAYGLLLPQEVLDIPRAGCINIHASLLPRWRGAAPIHRAIEAGDAETGVTLMQMDVGLDTGAMIEEARIAIAPDDTTATLHDRLAADGARLIVDALVRLERDGTLPATPQPADGVTYAEKIGKHEAALDWRKPADVLARQVRAFDPFPGGVATLDGAAIKLWAAEPVATDGTIASAAPGTIVEAAPEGVVVACGSGALRVTQLQKPGGKRLPAREFLAGSPLAAGQRFALPDVD
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RL14_SODGM
Sequence: MIQEQTMLTVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVVRFDGNACVLLNNNSEQPIGTRIFGPVTRELRTEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MNHF2_STAHJ
Sequence: MIETLTNFFITSALVLFGIAFIIGLFRLIKGPTTADRVVAFDASSAVIMCIIGIVSVIYNTVSFLDSIMLVAIISFVSSVSISRFIGGGRVFNGTNKRNH
What are the official names of this protein?
Putative antiporter subunit mnhF2, Mrp complex subunit F2, Putative NADH-ubiquinone oxidoreductase subunit mnhF2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DER_SHESA
Sequence: MIPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAFLSGYEFIVVDTGGIDGTEEGIETKMAEQSLAAIEEADVVLFMTDARAGLTAADLSIAQHLRSRQKTTFVVANKIDGIDADSACAEFWSLGLGEVYQMAAAQGRGVTNMIEYALTPYAEAMGIERQGEEEEVDERQYTEEEAEAEQKRLQDLPIKLAIIGKPNVGKSTLTNRILGEERVVVYDEPGTTRDSIYIPMERDGREYVIIDTAGVRRRSKVHEVIEKFSVIKTLKAVEDANVVLLIIDAREGIAEQDLGLLGFALNAGRALVIAVNKWDGIDQGIKDRVKSELDRRLGFIDFARIHFISALHGTGVGHLFESIEEAYDSATRRVSTSMLTRIMQMSQDDHQPPLVNGRRVKLKYAHAGGYNPPIVVIHGNQVSKLPDSYKRYMMNYFRRSLKVVGTPIQLRFQEGDNPFENKVEKLTMSQERRRKRALSHIKDRKTK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: HOGA1_XENLA
Sequence: MFGRTLFPARALCSGLFKTPLRTLATRPALSIGGIYPPIATPFTDKEEVDYGKLHENLQKYCSFPFSGFVVQGSNGEYAYLTREERLEVVRRVRQAVPKEKLIMAGSGCESTQATIEMTVEMARSGADVVLVVTPSYYRGKMTSSALVHHYTKVADHSPVPVVLYSVPANTGLDLPVDAVVTLSQHPNIIGLKDSGGDITRIGLIIHKTKHLGFQVLSGSAGFLLAGYSVGAVGGVCALANVLGAQVCELEKLCLNGRWQEAKELQHRLIEPNSAVTRKFGIPGLKQAMDWFGFNGGKCRSPLLPLTEQEIKELRHIFTVNGWLSS
What is the function of this protein?
Catalyzes the final step in the metabolic pathway of hydroxyproline.
What are the official names of this protein?
4-hydroxy-2-oxoglutarate aldolase, mitochondrial, Dihydrodipicolinate synthase-like, DHDPS-like protein, Probable 2-keto-4-hydroxyglutarate aldolase, Probable KHG-aldolase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MSRA_XANC8
Sequence: MLGIGAFKQRMPRSGEALPGRTQALPLHNTHLINGHPLRGEFTGLAQVQFGLGCFWGAERKFWNVPGVYTTAVGYAGGKTPNATYSEVCSGQTGHTEAVLVVYDAQAVSFEQLLRTFWESHDPTQGMQQGSDVGTQYRSAIYCSTQAQYDAAIASRDAYQQQLTAAGYGDITTEILYPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: EMC10_BOVIN
Sequence: MSVPAAGATRLLLLLLVAAATPSRARGSGCRSGAAVRGVGVEGREGEGCGTVGLLLEHSFEIDDSAHFRKRGSLLWNQQDGTLSLSQRQLNEEERGRLRDVAALNGLYRVRVPRRPGAPDGPEAGGYVSSFVPACSLVESHLSDQLTLHVDVAGNVVGVSVVTYPGGCRGHEVEDVDLELFNTSVQLQPPVTAPGPETAAFIERLEMEQAQKAKNPQEQKSFFAKYWMYIVPVVLFLMMSGAPDAGGQGGGGGGGGGGGSGR
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.  Promotes angiogenesis and tissue repair in the heart after myocardial infarction.  Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.
What are the official names of this protein?
ER membrane protein complex subunit 10.
What is the protein family that this protein belongs to?
Belongs to the EMC10 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.