PharMolix/UniProtQA huggingface dataset:
Protein: RSKA_MYCUA
Sequence: MTEPTDFQLLELATPYALHAVSDEERLDIERRLSAAPAPVAAAFDEEVRSVRETMSVVSAATAAQPPAELRQALLAAAEPAQSRRQPRWRTAVFASAAAIAVGLGAFGLGVLTRPSASPTVAEQVLAAPDVQTVSGRLGGGTATVMFSRDRNAGVLVMNNVPPPSPGTVYQMWLVDAKGPTSAGTMGPTAVTPSTKATLTDLGDSTTLAFTVEPGTGSTKPTGTVLAELPLR
What is the function of this protein?
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK.  ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP).  RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor (By similarity).
What are the official names of this protein?
Anti-sigma-K factor RskA, Regulator of SigK, Sigma-K anti-sigma factor RskA.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-K factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RECR_RICRS
Sequence: MNETNYNDIDQLIYLFSKLPGLGIRSARRIALYLLQDKDVRLKSLINNLVEIDKKIVKCEICGNMDTENICRICSSEYRDKSIIAIVETVAELWAMERSGNFKGLYHVLGHNLSAASRQNPSILRLPELLTRCFAENIKEVIIATNSTLEGQTTAYFITEYLKEHPAKISRLASGIPIGGELDYLDEGTVSAAINLRQPFE
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: GG_EHV1B
Sequence: MLTVLAALSLLSLLTSATGRLAPDELCYAEPRRTGSPPNTQPERPPVIFEPPTIAIKAESKGCELILLDPPIDVSYRREDKVNASIAWFFDFGACRMPIAYREYYGCIGNAVPSPETCDAYSFTLIRTEGIVEFTIVNMSLLFQPGIYDSGNFIYSVLLDYHIFTGRVTLEVEKDTNYPCGMIHGLTAYGNINVDETMDNASPHPRAVGCFPEPIDNEAWANVTFTELGIPDPNSFLDDEGDYPNISDCHSWESYTYPNTLRQATGPQTLLVGAVGLRILAQAWKFVGDETYDTIRAEAKNLETHVPSSAAESSLENQSTQEESNSPEVAHLRSVNSDDSTHTGGASNGIQDCDSQLKTVYACLALIGLGTCAMIGLIVYICVLRSKLSSRNFSRAQNVKHRNYQRLEYVA
What is the function of this protein?
Chemokine-binding protein that inhibits neutrophils' chemotaxis.
What are the official names of this protein?
Envelope glycoprotein G, gG.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein G family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein.
Protein: RS8_FRASN
Sequence: MTMTDPIADMLTRVRNANRAYHDRVVMPHSKIKTHIAEILQQEGYILGWHVEDPAEGAVGRTLIVDLKYGPNRERSIAGVKRISKPGLRVYAKSTNLPKVLGGLGVAIISTSSGLLTDRQAGKRRVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: CAIT_ECO5E
Sequence: MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFLWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD
What is the function of this protein?
Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
What are the official names of this protein?
L-carnitine/gamma-butyrobetaine antiporter.
What is the protein family that this protein belongs to?
Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACPH_SHISS
Sequence: MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRFINLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMAQASHKAL
What is the function of this protein?
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
What are the official names of this protein?
Acyl carrier protein phosphodiesterase, ACP phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the AcpH family.
Protein: T2R43_MACMU
Sequence: MITFLPIIFSILVVFTFVIGNFANGFIALVNSIEWVKRQKISFADQILTALAVSRVGLLWILLLNWYSTVLNPAFYSVEVRTIAYNLWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLRRRVKSVVLVILWGPLLFLVCHLFVVNMNEIIQTKEYEGNMTWKSKLRSAMYLSNTTVTILANLVPFILTLISFLLLICSLCKHLKKMQLRDKGSQDPSTKVHIKALQTVISLSLCAIYFLSIMISSWSLGRVENKAIFMFCKAIRFSYPSAHAFILIWGNKKLKQTLLSVLWNVRYCVKGQKLQSP
What is the function of this protein?
Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5.  Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.  In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.  May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 43, T2R43.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia.
Protein: HIS7_RHOE4
Sequence: MSDRIARIERTTRESSIVVELNLDGTGIVDVSTGVPFFDHMLNALGTHASFDLDVKAKGDVEIDAHHTVEDTAIVFGQALGQALGDKKGIRRFGDAFIPMDETLAHASVDVSGRPYCVHTGEPDYMVHSVIGGYPGVPYHAVINRHVFESIALNARIALHVRVLYGRDQHHITEAEYKAVARALREAVEPDPRVSGVPSTKGTL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPX_LACLM
Sequence: MITIYTAPSCTSCKKAKTWLSYHHIPFNERNLIADPLSTTEISQILQKCDDGVEGLISSRNRFVKTLGVDFEDISLSQAIKIISENPQIMRRPIIMDEKRLHVGYNEEEIRAFLPRTVRVLENGGARLRSAI
What is the function of this protein?
Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes.  Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP).  This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
What are the official names of this protein?
Global transcriptional regulator Spx.
What is the protein family that this protein belongs to?
Belongs to the ArsC family. Spx subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNZ_DROME
Sequence: MYLVKSAGSPIYRTLRTLTTSNLMAATIASAKDPLTGPRYEREPNVLRKKLASVVPGTVNLQVLGSGANGAPAAVYLFTDQARYLFNCGEGTQRLAHEHKTRLSRLEQIFLTQNTWASCGGLPGLTLTIQDAGVRDIGLHGPPHLGSMLQSMRRFVVLKNLQVRPNDCSEGACFEDSILKVDSLPLINSEDPTKSVINYICQLKPRAGALNLVKCVEQGVPPGPLLGQLKNGNDITLPDGKVVRSVDVTEASETALSFVFLDVPSENYLPALLTHGKRLKKLGEEKLTEVALVVHFTPYHISSRQVYKDFVVESFSSEAQHIYLSSPLNQFSGYAAAHRIQHQLHQLAPQVFPLLGEQLSCQSQTLSLNLKKTKLDEADSEDKANAKANETEEQGVVAMTNYHLRPRKGLDRTLESKLTPEEYVKETHAVPGFLELLAKFKEEYSFPDNSADSYPKIIFLGTGSCIPNKTRNVSSILIRTAIDAYVLLDCGEGTYGQIVRLYGHEKGQLILRQLQAIYVSHLHADHHIGLIGLLRERRQLKPRADPLILLAPRQIEPWLEFYNRQIETVEDAYTLVGNGELLASPLSGEQVERLGITSISTCLVRHCPNSFGISLTLAAKHNSEPVKITYSGDTMPCQDLIDLGRDSTVLIHEATMEDDLEEEARLKTHSTVSQAIQQGRNMNARHTILTHFSQRYAKCPRLPSDEDMQRVAIAFDNMEVTIEDLQHYHKLYPALFAMYAEYTEELEQRAVKRELKQERKRKLAET
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity of nuclear and mitochondrial pre-tRNA.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.  May participate in tRNA processing in the developing embryo.
What are the official names of this protein?
Ribonuclease Z, mitochondrial, RNase Z, Juvenile hormone-inducible protein 1, dRNAse Z, tRNA 3 endonuclease, DmeZ, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: AAP1_YEAST
Sequence: MSREVLPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEVNKNENQQKATLVFPNGTFENLGPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKKYTTFNTTPKMSTYLVAFIVADLRYVESNNFRIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTFNIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGKDVCSVMNIWTKRVGFPVLSVKEHKNKITLTQHRYLSTGDVKEEEDTTIYPILLALKDSTGIDNTLVLNEKSATFELKNEEFFKINGDQSGIFITSYSDERWAKLSKQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYANGNKQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLDGTVLNQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYSRKVTKGFDQTLAQALDTIRSKAQWVSRDREIVATYLREHEYDQ
What is the function of this protein?
Positive effector of glycogen accumulation.  May be involved in nutrient-sensing.
What are the official names of this protein?
Alanine/arginine aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
Protein: INSI2_RAT
Sequence: MAEGETESPRPKKRGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVITSIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE
What is the function of this protein?
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR.  Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2.  Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum.  In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi.  Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2.  Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.
What are the official names of this protein?
Insulin-induced gene 2 protein, INSIG-2.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TPH1_RAT
Sequence: MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV
What is the function of this protein?
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
What are the official names of this protein?
Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Protein: Y3269_MAGSA
Sequence: MWTIPTYILAAFAEIGGCFAFWAWLRLDKSPLWLVPGMASLGLFAWALTRIDADFAGRAYAAYGGIYILASLIWMWAVEGTRPDRWDTIGAAICVVGAMVIIFGPRST
What are the official names of this protein?
UPF0060 membrane protein amb3269.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CASQ2_PIG
Sequence: FNEEGSLYILKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIINSKLEVQAFERIEDHIKLIGFFKSEDSEYYKAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMEEPIVIPDKPYTEEEIVEFVKEHQRPTLRRLRPEDMFETWEDNLNG
What is the function of this protein?
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.  Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits.  Can bind around 60 Ca(2+) ions.  Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction.  Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
What are the official names of this protein?
Calsequestrin-2, Calsequestrin, cardiac muscle isoform.
What is the protein family that this protein belongs to?
Belongs to the calsequestrin family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum lumen. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
Protein: RIMP_ECOLC
Sequence: MGLSTLEQKLTEMITAPVEALGFELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPLFTAEHYARFVGEEVTLVLRMAVQNRRKWQGVIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICP4_HHV2H
Sequence: MSAEQRKKKKTTTTTQGRGAEVAMADEDGGRLRAAAETTGGPGSPDPADGPPPTPNPDRRPAARPGFGWHGGPEENEDEADDAAADADADEAAPASGEAVDEPAADGVVSPRQLALLASMVDEAVRTIPSPPPERDGAQEEAARSPSPPRTPSMRADYGEENDDDDDDDDDDDRDAGRWVRGPETTSAVRGAYPDPMASLSPRPPAPRRHHHHHHHRRRRAPRRRSAASDSSKSGSSSSASSASSSASSSSSASASSSDDDDDDDAARAPASAADHAAGGTLGADDEEAGVPARAPGAAPRPSPPRAEPAPARTPAATAGRLERRRARAAVAGRDATGRFTAGRPRRVELDADAASGAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSRPGLWGAPEAEEARARFEASGAPAPVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVAPGDVALDQACFRISGAARNSSSFISGSVARAVPHLGYAMAAGRFGWGLAHVAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAALTGARTPDDGGDANRHDGDDARGKPAAAAAPLPSAAASPADERAVPAGYGAAGVLAALGRLSAAPASAPAGADDDDDDDGAGGGGGGRRAEAGRVAVECLAACRGILEALAEGFDGDLAAVPGLAGARPAAPPRPGPAGAAAPPHADAPRLRAWLRELRFVRDALVLMRLRGDLRVAGGSEAAVAAVRAVSLVAGALGPALPRSPRLLSSAAAAAADLLFQNQSLRPLLADTVAAADSLAAPASAPREARKRKSPAPARAPPGGAPRPPKKSRADAPRPAAAPPAGAAPPAPPTPPPRPPRPAALTRRPAEGPDPQGGWRRQPPGPSHTPAPSAAALEAYCAPRAVAELTDHPLFPAPWRPALMFDPRALASLAARCAAPPPGGAPAAFGPLRASGPLRRAAAWMRQVPDPEDVRVVILYSPLPGEDLAAGRAGGGPPPEWSAERGGLSCLLAALGNRLCGPATAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLAGACDRRLIVVNAVRAADWPADGPVVSRQHAYLACEVLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGANVRYRVRTRFGPDTLVPMSPREYRRAVLPALDGRAAASGAGDAMAPGAPDFCEDEAHSHRACARWGLGAPLRPVYVALGRDAVRGGPAELRGPRREFCARALLEPDGDAPPLVLRDDADAGPPPQIRWASAAGRAGTVLAAAGGGVEVVGTAAGLATPPRREPVDMDAELEDDDDGLFGE
What is the function of this protein?
Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription (PubMed:30619292).  Binds with high affinity to the sequence 5'-ATCGTC-3'.  Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation.  Negatively regulates its own transcription.  This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription (By similarity).  In addition, binds to the host promoters of CXCR3 ligands including CXCL9, CXCL10, and CXCL11 and interacts with TBP to activate their transcription.  In turn, mediates CD4+ T-cell migration (PubMed:30619292).
What are the official names of this protein?
Major viral transcription factor ICP4 homolog, Alpha-4 protein, Infected cell protein 4, Transcriptional activator IE175.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae ICP4 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Virion tegument. Note=Localizes to the cytoplasm when phosphorylated.
Protein: Y893_HAEIN
Sequence: MRQAKTDLAEQIFSATDRLMAREGLNQLSMLKLAKEANVAAGTIYLYFKNKDELLEQFAHRVFSMFMATLEKDFDETKPFFEQYRQMWKNIWYFLQENPTILSNLKQYESLPNFKDICKNIKNCRWDLFCHQAQKAGLLAELSEDILFLLSLKTAINLASDAKFIDFDLKPEILESVIERSWRAIQK
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator HI_0893.
Protein: ICCD_TALVA
Sequence: MASSEVFTSEEAAQRAIKTYYESQESRMGYELVFGGTQHFGYYTPGTWSPFPIDKSLRRMEEKLMGWLALPAGSRILEAGCGVGHVALYLAKHGMRVTGVDIIDHHVEQARRSAQKANLPKDQIVIEKMDFERLEAIPSASHDGAFTMQSLGHAFSAEKALAGFFRVLKPGGRFALVEVERRPNAEADKKNPRLTEQLSMINVGTGMPTNERSHDGFYKGLLEEAGFVDIESRDISDNILPVVRMFYVVLLVPYLFVRLLGIEKHFVSMLAGTAGYVGYDRWRFMVVTGRKP
What is the function of this protein?
S-adenosyl-l-methionine-dependent Diels-Alderase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:30905148).  IccD catalyzes the Diels-Alder reaction that converts the acyclic 2-pyridone intermediate to 8-epi-ilicicolin H (PubMed:30905148).  The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iccA with the partnering trans-enoyl reductase iccB since iccA lacks a designated enoylreductase (ER) domain.  The cytochrome P450 monooxygenase iccC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone.  The pericyclase iccD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H.  Finally, the epimerase iccE converts 8-epi-ilicicolin H into ilicicolin H via epimerization.  IccA to iccE are sufficient for ilicicolin H biosynthesis and the roles of the remaining enzymes, iccF, iccG and iccH within the pathway have still to be determined (PubMed:30905148) (Probable).
What are the official names of this protein?
S-adenosyl-L-methionine-dependent Diels-Alderase iccD, C-methyltransferase iccD, C-MT iccD, Ilicicolin H biosynthesis cluster protein D, Pericyclase iccD.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CCB13_ORYSJ
Sequence: MASRRQWGAGAGAVDVPAQERKGGKAATDHLLRAFFAVFFVLEGLSWRRRRRRDGEGVFLLRYVACLLCLQAAKIARRPKTTTVVAQQPPRIRRALADVSNLVNGRAALPVVNRQKAAAAAADKCRKPIKQRNENNKAAKPEVIVISSDSEKHKKNPAQRAASRRAPIQTLTSILTKCSRASDGVISPKKELIYDIDASDSHNELAVVDYVEDIYRFYRNTENTYRPLCTYMVSQTEINERMRAILTDWLIEVHYRLMLMPETLYLTVYIIDQYLSLENVPRKELQLVGVSAMLIACKYEETWAPLVKDFLVISDNSFSRQQVLSTEKSILNKLQWNLTVPTMYMFILRYLKAALGDEELEHMTFFYAELALVQYSMLFFAPSVIAAAAVYAARCTLGLSPLWSDLLEYHTGLAEPQLLECARRLVSLHAAAPESRQKVVYKKYASPKLGAVSLHSPAKKLLPPPSPVAA
What are the official names of this protein?
Cyclin-B1-3, CYCB1;1, G2/mitotic-specific cyclin-B1-3, CycB1;3.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: MSCL_ECO81
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLREAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAATPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DEF_ECOSE
Sequence: MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: XERC_SHIB3
Sequence: MTDLHTDVERYLRYLSVERQLSPITLLNYQRQLEAIINFASENGLQSWQQCDVTMVRNFAVRSRRKGLGAASLALRLSALRSFFDWLVSQNELKANPAKGVSAPKAPRHLPKNIDVDDMNRLLDIDINDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLESGEVWVMGKGSKERRLPIGRNAVAWIEHWLDLRDLFGSEDDALFLSKLGKRISARNVQKRFAEWGIKQGLNNHVHPHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates.  The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.  In the complex XerC specifically exchanges the top DNA strands.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.