PharMolix/UniProtQA huggingface dataset:
Protein: ODC_HUMAN
Sequence: MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW
What is the function of this protein?
Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877).  Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate (PubMed:11083877).  Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable).
What are the official names of this protein?
Mitochondrial 2-oxodicarboxylate carrier, ODC, Mitochondrial 2-oxoadipate carrier, Solute carrier family 25 member 21.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: RL2_XANOR
Sequence: MPLMKFKPTSPGRRSAVRVVTPDLHKGAPHAALLDSQSKSGGRNHHGRITVRHVGGGHKQHYRIIDFKRNKEGIPARVERIEYDPNRTAHIALLCYVDGERCYIIAPKGLKAGDQVIAGANAPIKTGNTLPLRNIPVGTTVHGIELKPGKGAQIARAAGAAVQLVAREGIYATLRLRSGEMRKVPVECRATIGEVGNDEHNLEKLGKAGAKRWRGVRPTVRGAAMNPVDHPHGGGEAKAGQGNPHPVTPWGVPTKGYKTRKNKRTQQFIVRDRRG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ARLY_ECOLI
Sequence: MALWGGRFTQAADQRFKQFNDSLRFDYRLAEQDIVGSVAWSKALVTVGVLTAEEQAQLEEALNVLLEDVRARPQQILESDAEDIHSWVEGKLIDKVGQLGKKLHTGRSRNDQVATDLKLWCKDTVSELLTANRQLQSALVETAQNNQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLARDESRLQDALKRLDVSPLGCGALAGTAYEIDREQLAGWLGFASATRNSLDSVSDRDHVLELLSAAAIGMVHLSRFAEDLIFFNTGEAGFVELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQVKRPRCQEAAQQGYANATELADYLVAKGVPFREAHHIVGEAVVEAIRQGKPLEDLPLSELQKFSQVIDEDVYPILSLQSCLDKRAAKGGVSPQQVAQAIAFAQARLG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T1843_DICDI
Sequence: MWIVAGVCSGVAILLSFYLIYKHLRNYTNPELQKYIVRILIMVPIYSVDSWLSLRFVELSLYFDVVRDTYEAYVLYCFFSLIVAYIERDFDLVELLHSKEPLPHPFPLTCLPKIKLDRGFLTNCKRFVLQFVFIKPIVAIISLVLETQHKYGEGKFQVGTGYVWLTVVENISVGLSLYFLVLYYKAMEEELKPFKPLGKFLCIKSILFFSFWQSIAISFLVYFGVISPIGSWSVDNISSALQDFITCVEMVILAICHHFFFNYQEFRDPHKVPFIYDKTTKTFFNNPKTNITPIIKNFFTNVTNISDVISDTRETFILPLLSPDHHHNHPTTKKKDEESNLLEPEDKDIII
What is the function of this protein?
Probable transporter.
What are the official names of this protein?
Transmembrane protein 184 homolog DDB_G0279555.
What is the protein family that this protein belongs to?
Belongs to the TMEM184 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PEPX_STREM
Sequence: MRYNQLSYIPTSLETAVAELQALGFAVQQEQAPKESFAIFLRKLFFHFQDTDYPLSHMIATKELDLLSFLASDEALTKEVFDLVALQVLGFIPAVDFTDTQDFIQKIGFPIVFDSQQLLLNLHQLLATRQKSGVTLIDSLVSQGLLPMDNCYHYFNGKALATFDTTSLIREVVYVEAPLDTDQDGQLDLIKVNIIRPKASTAIPSMMTASPYHQGINETANDKKLHRMEGELSPKAPRRITVEPTDFQPLATKPSRLPVNECQETFSHISSYTLNDYFLARGFANLYVSGVGTAGSTGFMTSGDYAQIESFKAVIDWLNGRATAYTSHKRDYQIKADWSNGLVATTGKSYLGTMSTGLATTGVDGLAVIIAEAAISSWYDYYRENGLVCSPGGYPGEDLDVLTELTYSRNLLPGDYLRHNDHYQQLLSQQSQALERQSGNYNQFWHDRNYLPQADHIKCEVVYTHGLQDWNVKPRQVYNIFNALPDGLGKHLFLHHGEHVYMHNWQSIDFREAMNALLCQKMLGQNNGFTLPTIIWQDNQKEQTWKELTAFGGHSKRQIALGEDHVLIDNHYGEEDFKRYSKDFRAFKAELFEGKANQAVIDILLEEDLPINGQACLKLKLKSSENKGILSAQLLDYGKKKRFADIPAILELDSIDNGQQFAREALKELPFKDSPYRVVTKGVLNLQHRSNLLTIEDIPNDQWMTITFHLQPTIYHMAKGDTLRVVLYTTDFEHTIRDNSNYALTLDLEQSYLLIPTDEEE
What is the function of this protein?
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Xaa-Pro dipeptidyl-peptidase, X-Pro dipeptidyl-peptidase, X-prolyl-dipeptidyl aminopeptidase, X-PDAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_XYLFA
Sequence: MTPIVFIDRDGTLIEEPPDFQIDAYEKLRLVNGVIPALLKLRDAGYHFVIVTNQDGLGSPAYPQASFDGPNALMLQIFSSQGIVFRDVLIDRSWPTDNAPTRKPGIGLMVAYLQDRDIDWARSAMVGDRPTDLQFAENLNIRGFQLRTPQFGGDWDWDGIAHTLADAPRRAVVQRHTKETTIRVEIDLDGAPQARITTGLPFFDHMLEQIAKHAGISLQISAVGDLHIDEHHTIEDTGLALGQAVRQALGDKRGIGRYGFDPPQLPWQVSGAAAHGGFTLPMDETQASAVLDFSGRPYCVFEGTFVRERVGDMPTELVPHFFRSLCDASGMNLHLSVHGDNDHHKVEACFKALARALRQALQRHGHVLPSTKGAL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_RICFE
Sequence: MKQYNDLFKIIHREGYIFIASFALVSFLLASFNEKLGCIGFIATAWCIYFFRNPDRFVPISDDLVISPADGIIQEIKEALPPPELGLGDVEMIRVSIFLNIFNVHVNRIPANGKILALHYNPGKFFNASLDKASIYNERQSVLMETDQGQKIVFVQIAGLIARRIVCDLEEGNEVKTGERYGIIRFGSRVDVYLPLKTALLVSKGQTAIGGETIIADFGRKKTAEFKFERK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: OATA_STAA8
Sequence: MDTKDFKRLEKMYSPRYLPGLDGLRAFAVIGIIIYHLNAQWLSGGFLGVDTFFVISGYLITSLLISEYYRTQKIDLLEFWKRRLKRLIPAVLFLICVVLTFTLIFKPELIIQMKRDAIAAIFYVSNWWYISQNVDYFNQFAIEPLKHLWSLAIEEQFYLLFPLVITFLLHRFKPRNIIQTLFIVSLISLGLMIVIHFITGDNSRVYFGTDTRLQTLLLGCILAFIWPPFALKKDISKKIVVSLDIIGISGFAVLMTLFFIVGDQDQWIYNGGFYIISFATLFIIAIAVHPSSLFAKFLSMKPLLIIGKRSYSLYLWHYPIIVFVNSYYVQGQIPVYVYIIEILLTALMAEISYRFIETPIRKKGFKAFAFLPKKKGQFARTVLVILLLVPSIVVLSGQFDALGKQHEAEKKEKKTEFKTTKKKVVKKDKQEDKQTANSKEDIKKSSPLLIGDSVMVDIGNVFTKKIPNAQIDGKVGRQLVDATPIVKSQYKDYAKKGQKVVVELGTNGAFTKDQLNELLDSFGKADIYLVSIRVPRDYEGRINKLIYEAAEKRSNVHLVDWYKASAGHPEYFAYDGIHLEYAGSKALTDLIVKTMETHATNKK
What is the function of this protein?
Responsible for O-acetylation at the C(6)-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan (PubMed:15661003, PubMed:32350117).  O-acetylation of the peptidoglycan is the major determinant for lysozyme resistance (PubMed:15661003).
What are the official names of this protein?
O-acetyltransferase OatA.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ECH17_MYCBP
Sequence: MAAVTPTVPEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQEADTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLIPSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALGLIDDMVAPDDVYDAAAAWARRFLDGPPHALAAAKAGISDVYELAPAERIAAERRRYVEVFAAGQGGGSKGDRGGR
What is the function of this protein?
Could possibly oxidize fatty acids using specific components.
What are the official names of this protein?
Probable enoyl-CoA hydratase EchA17.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: LONB_METJA
Sequence: MFSIKFKTTEELPEPSPRLIDQVIGQEEAVKIVLSAVKNKRNVILLGDPGVGKSMIVKAVGEILSDFGEFTPYYVIAKPNLKNMERPIVEVIDGEYKEDSKDMPKLDFKAPSSTTLLLIMIGAILLSEYLLKYLPQNYLLAAVTITALIVLIFGFVIILTSIMGASRASMPNNLNPMDLKPVLLYECKKRPLVRASAYNVTRLLGDIKHCPLGGRPPLGTPPHKRIILGAIHEAHRGILYVDEIKTMPLEVQDYILTALQDKQLPISGRNPNSSGATVETNPIPCDFILIMSGNMDDVYNLRAPLLDRIDYKIVLKNKMDNTLENRDKLLQFIVQEIKNNNLNPMTYDGCCEVVRIAQYLAGSKDKLTLRLRLLANIIKMANDVAMGKDVEELLGNFDDKGEYHPETQKDKSNKVYITAEHVRKVFDTGIYSMEKQVALNYIKNFKRYKHIVPNDEPKVGVIYGLAVLGAGGIGDVTKIIVQILESKNPGTHLLNISGDIAKHSITLASALSKKLVAEKKLPLPKKDIDLNNKEIYIQFSQSYSKIDGDSATAAVCLAIISALLDIPLKQDFAITGSLDLSGNVLAIGGVNEKIEAAKRYGFKRVIIPEANMIDVIETEGIEIIPVKTLDEIVPLVFDLDNRGGAERFN
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Degrades polypeptides processively (By similarity).
What are the official names of this protein?
Archaeal Lon protease, ATP-dependent protease La homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family. Archaeal LonB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACCA_FRATW
Sequence: MNYLDFESKIKEIEDKITSLSHVFEDEKTEAEIKKLSKKRLELMESTYSKLTDWQVVQLSRHPDRPYFKDLLPLIFTDFQELHGDRTFGDDLAVIGGLAKLNNKPVMVIGQEKGRDTKSKIKHNFGMMHPEGYRKALRLMKLAEKFNMPVVTFIDTPGAYPGIKAEERGQSEAIARNLLEMSALKVPVVCIVIGEGCSGGALGIGVGDRLLMLQYSYFATISPEGCASILHKTAEKASEVTQMMNITSGRLKELKIVDEVIPEPLGGAHRDYETTATNIRKAVAAELKILSEMTVEQRNSRRYDKLMSFGRFKEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKNF_MYCBO
Sequence: MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADFGIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPFQHANPAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGHRLGGAGDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVTVREFQRADDERAAQPARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP
What are the official names of this protein?
Serine/threonine-protein kinase PknF.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: F6H1_ARATH
Sequence: MAPTLLTTQFSNPAEVTDFVVYKGNGVKGLSETGIKALPEQYIQPLEERLINKFVNETDEAIPVIDMSNPDEDRVAEAVCDAAEKWGFFQVINHGVPLEVLDDVKAATHKFFNLPVEEKRKFTKENSLSTTVRFGTSFSPLAEQALEWKDYLSLFFVSEAEAEQFWPDICRNETLEYINKSKKMVRRLLEYLGKNLNVKELDETKESLFMGSIRVNLNYYPICPNPDLTVGVGRHSDVSSLTILLQDQIGGLHVRSLASGNWVHVPPVAGSFVINIGDAMQIMSNGLYKSVEHRVLANGYNNRISVPIFVNPKPESVIGPLPEVIANGEEPIYRDVLYSDYVKYFFRKAHDGKKTVDYAKI
What is the function of this protein?
2-oxoglutarate (OG)- and Fe(II)-dependent dioxygenase (2OGD) involved in scopoletin biosynthesis (PubMed:18547395, PubMed:29581584).  Converts feruloyl CoA into 6'-hydroxyferuloyl CoA but has no activity with ferulic acid, feruloylquinic acid, caffeic acid, caffeoyl CoA, p-coumaric acid, cinnamic acid, cinnamoyl CoA or benzoyl CoA (PubMed:18547395).  Required for the production and secretion of compounds (e. g.  fluorescent coumarins) that facilitate the mobilization and uptake of iron from sources with low bioavailability or in high pH-induced iron deficiency conditions (PubMed:23735511, PubMed:24246380).  Involved in the pathway of sideretin biosynthesis from feruloyl CoA, a redox-active catecholic metabolite exuded by roots in response to iron deficiency in order to facilitate the uptake of iron; this pathway consists in the successive conversion from feruloyl CoA to scopoletin, from scopoletin to fraxetin and from fraxetin to sideretin (PubMed:29581584).  Catalyzes the biosynthesis of scopoletin from feruloyl CoA (PubMed:29581584).
What are the official names of this protein?
Feruloyl CoA ortho-hydroxylase 1.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: CO7_HUMAN
Sequence: MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPLWGKCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAAETQ
What is the function of this protein?
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.  C7 serves as a membrane anchor.
What are the official names of this protein?
Complement component C7.
What is the protein family that this protein belongs to?
Belongs to the complement C6/C7/C8/C9 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FHL_ARATH
Sequence: MDDADKSCSPSLDHSDINDPMIVAVESLDTSKKRKLHAEESDLLPLPKHFCSEHQASLVNSSCPSSVIDYAECSYAMENTKTSDEASSSASFTGPSLYMFKDSIYSTGSSSSGYAATSSIEQCFSKVDHKTQEDTQDFTHMEFIYHDSEFAVEDLQEVLNPVESYILSSARWSVSNQDSKEATTKPTIDQEFEQYFSTLMM
What is the function of this protein?
Can activate transcription (By similarity).  Essential for light-regulated PHYA nuclear accumulation and subsequent PHYA phototropic signaling processes (PubMed:21969386, PubMed:22374392, PubMed:17566111).  PHYA-specific signal transducer in response to continuous FR lights.  Mediates the association of PHYA with HFR1 and LAF1 in the nucleus in response to FR conditions (PubMed:19482971, PubMed:16045472).  Contributes to inhibition of hypocotyl elongation in continuous blue light (B) (PubMed:16045472).
What are the official names of this protein?
Protein FAR-RED-ELONGATED HYPOCOTYL 1-LIKE.
What is the protein family that this protein belongs to?
Belongs to the FHY1 protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles from cytoplasm to nuclear bodies in FR but stay in the cytoplasm in other light conditions.
Protein: MURI_ECO45
Sequence: MATKLQDGNTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRHLLPDLHYIYAFDNVAFPYGEKSEVFIVERVVEIVTAVQERYPLALAVVACNTASTVSLPALREKFDFPVVGVVPAIKPAARLTANGIVGLLATRGTVKRSYTHELIARFANECQIEMLGSAEMVELAEAKLHGEDVSLDALKRILRPWLRMKEPPDTVVLGCTHFPLLQEELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSADANIAFCMAMTPEAEQLLPVLQRYGFETLEKLAVLG
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: CAS10_MYCTU
Sequence: MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWLRDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYNIAAGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPSPRRIEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFDHLKLTGALGACIWHYLQATGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIHSSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNYSGGGHAYLLLPNTESARKSVEQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELSEQLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTAASSQIQSESRRFLLISDGATKGLPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFAGECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLGQAFTHGFMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVVGAWDDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRHIADYFSGNEERGMAFIYKLLELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHLYIYRTRKEESE
What is the function of this protein?
When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP.  cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.
What are the official names of this protein?
CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ssDNase Cas10, Cyclic oligoadenylate synthase.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Cas10/Csm1 family.
Protein: YQHA_SALPC
Sequence: MERFLENVMYASRWLLAPVYFGLSLALIALALKFFQEILHVLPNVFALAEADLILVLLSLVDMTLVGGLLVMVMFSGYENFVSQLDISAGKEKLNWLGKMDATSLKNKVAASIVAISSIHLLRVFMDAKNVPDNKLMWYVIIHLTFVLSAFVMGYLDRLTRHNH
What are the official names of this protein?
UPF0114 protein YqhA.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXB_SHIB3
Sequence: MKILVDENMPYARDLFSRLGEVTAVPGRPIPVAQLADADALMVRSVTKVNESLLAGKPIKFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSSLLMLAERDGFSLHDRTVGIVGVGNVGRRLQARLEALGIKTLLCDPPRADRGDEGDFRSLDELVQHADILTFHTPLFKDGPYKTLHLADEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQKLSVVLDVWEGEPELNVELLTKVDIGTPHIAGYTLEGKARGTTQVFEAYSKFIGHEQHVALDTLLPAPEFGRITLHGPLDQPTLKRLVHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVICDDASAASLLCKLGFNAVHHPAR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUNIP_RAT
Sequence: MSRRGPEEEACGVWLDAAALKRQKMQTHLLKLGTKMLTLLPGERKPSIPFTQRRATRQTSITSFVTSQPGMANGGNQKNASSLKENQINRECKSRSQLDCLDQGLEDDCLVSPLATSTPADIREAGHSPQSSQISGCQSLETTSLTMMSFPQPVVLMGTGESKAPLASSFTQFLERSCLLDQREAKRKREGLCGSKTDCPGMGSHIRPPGGKCHQPLDKAKVEKRATAKENRQAPVHLQTYRFGSHSGKKTLLVTKSPCPLSVFSWDIDRKDRDSWSQLFTEDSQGHQVIAHSTKMPFQDVTNARNQGSGQFPDSPQAQGQDGPTLLHLQPHLLFTQDSEGNRVIRH
What is the function of this protein?
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination.  Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair.  Inhibits non-homologous end joining (NHEJ).  Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
What are the official names of this protein?
Aurora kinase A and ninein-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the AUNIP family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks. Localizes to the centrosome in interphase and to the spindle pole in metaphase.
Protein: MSBA_SHEON
Sequence: MTASPKNEMWTVFKRLMGYLKPMKGMFLLSVVGLIVYGLVDAAFISFIGPFIDKGFSSSAPAISNGIALPTSQGFHADNQVLLMAPIVVILMFSLRGFANFVSTYGISYMSARLIMDMRQQVFEHYLSLPVSYMDKENTGNLISKVTFDTEQIARASGSALISIVRDSVTIIGMLGLMFYNSWKLSLCILVIGPIMGVVITIVSRRFRKVSKQIQTAMGDVSAATEQMIKGHKNVLAFGGQETETARFAKINDRNRHQNMKLAVAQAVSQPLIMVIGSFALAFVLYAASLDSMKADLTAGTFATILGAMMAMLQPIKNLTRVNAEFQRGIAACTTVFELLDTVPESDTGTYTVARAKGNLRFDNVSFSYEGQERRALEKIDFEVSQGQTLALVGRSGSGKSTIASLVTRFYTGLESGDILLDDVSIYDYSLKSLRSQVALVSQQVTLFNDTIANNIAYAYPGEVTREQIIEAATLAHAMEFIEQLPDGLDTQVGENGVLLSGGQRQRIAIARAMLRDAPVLILDEATSALDTESEKAIQQGLDNLRQNRTSVVIAHRLSTIESADQILVVDQGRIVERGTHKSLLELGGMYAKLYQMQFGS
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HGLB_SCHMA
Sequence: MMLFSLFLISILHILLVKCQLDTNYEVSDETVSDNNKWAVLVAGSNGYPNYRHQADVCHAYHVLRSKGIKPEHIITMMYDDIAYNLMNPFPGKLFNDYNHKDWYEGVVIDYRGKNVNSKTFLKVLKGDKSAGGKVLKSGKNDDVFIYFTDHGAPGLIAFPDDELYAKEFMSTLKYLHSHKRYSKLVIYIEANESGSMFQQILPSNLSIYATTAANSTECSYSTFCGDPTITTCLADLYSYNWIVDSQTHHLTQRTLDQQYKEVKRETDLSHVQRYGDTRMGKLYVSEFQGSRDKSSSENDEPPMKPRHSIASRDIPLHTLHRQIMMTNNAEDKSFLMQILGLKLKRRDLIEDTMKLIVKVMNNEEIPNTKATIDQTLDCTESVYEQFKSKCFTLQQAPEVGGHFSTLYNYCADGYTAETINEAIIKICG
What is the function of this protein?
This protease is used by the parasite for degradation of the host globin.
What are the official names of this protein?
Hemoglobinase, Antigen SM32.
What is the protein family that this protein belongs to?
Belongs to the peptidase C13 family.
Protein: PYRF_METRJ
Sequence: MTEIADPRDRLIVALDLPSVQAAEALIDRIGDAATFYKIGYQLGYAGGLALAERLAARGLKVFLDLKLHDIGNTVEEGVRSASGSGATFLTVHAYPQTMRAAVRGRGAGLRILAVTVLTSYDDADAAEAGYGLPVAELVAKRAAQAAEIGIDGLVCSAAEAGSVRRIVGPDRLIVTPGIRPAGAEAGDQKRVMTPGDARRAGIDHVVVGRPITGAADPRAVAQAIVADLA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RL11_METHJ
Sequence: MAEVVEVLVPGGKATAGPPLGPALGPLGINVKAVVDEINKKTASFNGMQVPVRVEVDEKKNFTISVGIPPTTALIMKEAGVEKGSGEPNTKIVGDVPLEAAVTIAKMKLDDMLSYDLKNAVKEVVGTCVSLGITVSGKKPKDMLKEIDSGAHDAVLVG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CFI2_LOTJA
Sequence: MALPSVTALQVENVAFPPTLIKPPASANTLFLGGAGERGLHIQDKFVKFTAIGIYLQDTAVPSLAVKWKGKPVDELTESVQFFRDIVTGPFEKFMQVTMILPLTGQQYSEKVSENCVAIWKHLGIYTDEEGKAIDKFVSVFKDQTFPPGSSILFTVLPKGSLAISFSKDGSIPEVESAVIDNKLLSEAVLESMIGAHGVSPAAKQSLASRLSELFKHHAEV
What is the function of this protein?
Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones.  Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.
What are the official names of this protein?
Chalcone--flavanone isomerase 2, Chalcone isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the chalcone isomerase family.