PharMolix/UniProtQA huggingface dataset:
Protein: SCUB2_MOUSE
Sequence: MGVAGCGRPREARALLLLLLLLPPLLAAAVPPDRGLTNGPSEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDMDECDNTLNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDMDECLENNGGCQHICTNVIGSYECRCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCGHICKEAPRGSVACECRPGFELAKNQKDCILTCNHGNGGCQHSCEDTAEGPECSCHPRYRLHADGRSCLEQEGTVLEGTESNATSVADGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPTGFTLQVDGKTCKDIDECQTRNGGCNHFCKNTVGSFDCSCKKGFKLLTDEKSCQDVDECSLERTCDHSCINHPGTFICACNPGYTLYSFTHCGDTNECSVNNGGCQQVCINTVGSYECQCHPGFKLHWNKKDCVEVKGFPPTSMTPRVSLHCGKSGGGDRCFLRCRSGIHLSSDVVTVRTSVTFKLNEGKCSLQKAKLSPEGLRPALPERHSSVKESFQYANLTCSPGKQVPGALGRLNAPKEMFITVEFERETYEKEVTASCNLSCVVKRTEKRLRKALRTLKRAAHREQFHLQLSGMDLDMAKTPSRVSGQHEETCGVGQGHEESQCVSCRAGTYYDGSQERCILCPNGTFQNEEGQVTCEPCPRPENLGSLKISEAWNVSDCGGLCQPGEYSANGFAPCQLCALGTFQPDVGRTSCLSCGGGLPTKHLGATSFQDCETRVQCSPGHFYNTTTHRCIRCPLGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRKCGGELGDFTGYIESPNYPGNYPANSECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK
What is the function of this protein?
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548).  Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195).  Synergizes with DISP1 to cause an increase in SHH secretion (PubMed:22902404).  Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).
What are the official names of this protein?
Signal peptide, CUB and EGF-like domain-containing protein 2, Protein CEGP1, Scube/You.
What are the subcellular locations of this protein?
Secreted. Cell surface. Note=Secreted and tethered at the cell surface.
Protein: FYV4_DEBHA
Sequence: MSFRLFARPLIQMPKLAAPRCINITPIRPISASAISLKTNTSTSTKENVHDLETFFKLIGRDCIEHLDAFESDLQKFLKTSSKDMKNMGIDVSTRRYMLRWIHKFQNDLEPLREHKRGKKKNGGERNAKTVLAKRTALKRLEEKERFESQELEAERKGEREF
What is the function of this protein?
Involved in telomere length regulation.
What are the official names of this protein?
Protein FYV4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TRM1_METMI
Sequence: MKIISEGETKLMVPEESTLSKKDTVFYNPVMETNRDISVSVVQSFLDDFKRDEFLMCDPLGGSGARGIRYAKELKFNGDLKVSIGDINPSAVKMIKENLKLNELENVEVFHEDANVLLSKNFKVFNVVDLDPFGSPVPYLDSGIRASLTKGGLLCMTATDTAVLCGAYRKTCIRKYNAVPLKGDKELAVRLMIGYAVKMASKYDIGLKPIFSHVTDHYARTFMVTERGAGKADSAIENLGYIRQDSEQKSFKTFEEGSEKGYAGPFYLGEISDKNIVQNALNTAKTRNYSKRAVNILEMISRESEINQVGCFDIHELCSFIKKLVPPVNDIMENLKENGFKVTRVHYNPYGLKTDAELSDLVVLISEYHSKKY
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: CLPP_STRP6
Sequence: MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGKTIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_BURP6
Sequence: MSIKSDKWIRRMAEEHKMIEPFVPDQVRAAEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEGSFVDFKGDVCIIPPNSFALARTVEYFRIPRTVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYANEGVAQVLFFESDEVCDVSYADRGGKYQGQRGVTLPKT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RR18_AGRST
Sequence: MYTSKQPFLKSKQPFRKSKQTFNKSKQTFRKSKQTFRKFKQPFRKSKQPFRRRPRIGPGDRIDYRNMSLINRFISEQGKILSRRINRLTLKQQRLITLAIKQARILSFLPFRNYENEKQFQAQSISIITGSRPRKNRHIPQLTEKYNSNRNLRNYNQNLRNINRNLSSD
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BIOH_SALPK
Sequence: MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLVDLPGYGRSSGFGAMTLEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGIKPEILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLKSVVLAQPMPDVEVLNGGLEILKTVDLREALKNVNMPFLRLYGYLDGLVPRKIAPLLDTLWPHSTSQIMAKAAHAPFISHPAAFCQALMTLKSSL
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_AGRRK
Sequence: MIGKLKGTIEEIGEDYALVDVHGVCYVAYCSARTLSRLGSVGEACILFIETYVREDQIRLFGFMAVLEREWFNLLQTVQGVGAKVALALLSTLTPSELANAIALQDRTAVSRAPGVGPKVAMRIVTELKNKVPAFAGEATNIGFKQELGEGVAPAPVSDAVSALTNLGYSRDQAANAIAAAMKVAGDEADSAKLIRLGLKELSR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: B1S3_LOXSN
Sequence: FALAHMVNDFDIMKSYLDEGANGIETDITFSPEGEPESAFHGVPCDCKRWCDRTVSFDSYLQKTSDLSTPGHPDYRENLLIIILDLKLNGLSQDALANGGRRLADKLAAHFWTVGRRDQRATFVVSVPQTSQKVFMKTFREGMEAIGMGDMNAKVGFDFTDNGDVSVTKAVYDELGITEHIWASDGITNCVALLFRGTSRLEELIQKRDEGESTYISKVYAWTYDKETSVVLALELGVDGVMTNYADFVISILNKPEHSSKYRLATYEDDPFERFKAV
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LspiSicTox-betaIE2iii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYE_SHESW
Sequence: MTTKTRFAPSPTGFLHVGGARTALYSWLQARANNGEFVLRIEDTDIERSTQAACDAILEGMNWLGLTWDEGPYYQTKRFDRYNEIIAQMLEKGTAYKCYCSRERIDALRESQAANGEAQKYDGCCRDLPARDTDEPFVVRFKNPIGGSVVFDDHVRGRIEFSNDALDDLIIARTDGVPTYNFCVVVDDWDMGITCVVRGEDHINNTPRQINILKALGAPIPEYAHVSMILGDDGAKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEVFSLEEMKQYFKLDDINKAPSAFNTDKLVWLNQHYIKTLDPEYVATHLQWHMDDQKIDTSNGPALAEVVTALAERAKTLKELAASSRYFYEDFADFDAEQAKKHLRGVALEPLQLVQQKLAALTEWTVEAIHQAIEQTATELDVGMGKVGMPLRVSVTGAGQSPGLDITLFLIGRSRSEQRISKAIEFVADRINS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETI_RHIME
Sequence: MPKVGMEPVRRKALVDAALRVIGDQGTLAVTMSEIARTAGVSPALAHHYFGSKEQLLIATIRSLLGKLRDDAVAAMKAAATPRERVSALIRVSFRADQFAPETVAAWLAFYSEAQRSEEVRRLLVIYARRLRSNLLVGLRALCPADDAERIAEGAAAMIDGLYIRQSLKSAPISIEASVALTEDYVNAHLRANGDGKYPSPRV
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: THIC_GEOSW
Sequence: MQNIKSFMQFPASKKVYVEGSRPDIRVPMREITLSPTKTETGIIENEPVRVYDTSGPYTDPDFQPDIQKGLPPLRKRWILERGDVEEYEGRPVKPEDNGFRNGKQSEITLPFERKPLRAKKGKTVTQMHYAKRGIITPEMEFVAIRENIDPEIVRQEVAAGRAIIPSNINHPESEPMIIGSRFHVKINANIGNSAVTSSIEEEVEKMLWAVRWGADTIMDLSTGKHIHATREYIIRNSPVPVGTVPIYQALEKVNGVVEDLTWEIYRDTLIEQAEQGVDYFTIHAGVLLRYIPMTVNRTTGIVSRGGSIMAQWCLAHHEENFLYTHFEEICEILKTYDIAVSLGDGLRPGSIADANDEAQFAELETLGELTEIAWKHDVQVMIEGPGHVPMHKIKENVDKQIEICKGAPFYTLGPLTTDIAPGYDHITSAIGAAIIGAYGTAMLCYVTPKEHLGLPNKDDVREGVIAYKIAAHAADLAKGHPGAQRRDDALSKARFEFRWNDQFNLSLDPDRAREYHDETLPAEGAKVAHFCSMCGPKFCSMKISHELQKTVREEGMKQKAKEFVENGSSLYR
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: SYS_PROM5
Sequence: MLDQKLIRENPTFVENNLSLRGKFYDIHSIHKITVERKEIDIKISSLQSESKKLSKIIGQEIRNPNNANSQELNKLKEQGNKYRIKVSEFEEKKRILDQQIRDEILKLPNFPSKDAPFGENESNNIQIKEWGDPLKKDNLKTHWEIGENLKLFDSIKSTKIAKSRFITLSGNGARLERALINFMLDVHSNNGYLELMPPALVNSESLQGSGQLPKFSNESFKCANDDLWLSPTAEVPLTAFHKNEIIDPKLLPLKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFSDPNKSLEAHKEITADAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSNKCYREISSCSNCRDFQARRSSIRTKIDKKTSYIHTLNGSGLAIGRTMAAILENGQRPDGSVKIPDVLVPYFGSSLIKTN
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_METKA
Sequence: MDVEERLKLVTRNAVEVVTEEELRQLLEEKEEPVAYVGFEPSGKVHLGHKLVIDKMIDLQEAGFHVIILLADLHAYLNEKGTLEEVRELADYNRRCFLAMGLDPNKTEFVLGSEFQLDEDYALDVYRMARHTTMRRARRSMDMIARSEENPPVSQVVYPLMQALDIVHLNVDLAVGGLEQRKIHMLARDVLPKLGYDSPTCLHTPIIHGLDGDEKMSSSKNNFIAVDDEPEVIREKLRKAYCPAREAEGNPILEIYRYFIFREYDEVTIERPEKYGGDVTYTSYEELERDFVDGELHPLDLKENAAGYLSEILKPVRKAVSAPS
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_HELAH
Sequence: MALNLEKKQEIIKAFATKENDTGSCEVQVALLNERIKLLTEHLKANPKDHSSRLGLLELVAQRRNLLKYIKRTDHARYVVLIEKLGIKDR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: MUTL_RHOPT
Sequence: MPVRQLPEIIVNRIAAGEVVERPASVVKELVENAIDAGSSRIDIFSDGGGRRKIVIADDGSGMTAADLALAVDRHATSKLDDEDLLQIRTLGFRGEALPSIGAVAKLSITTRHASEPHAWTLRVEGGDKTPIAPAALSQGTRVEVADLFFATPARLKFLKTDRTEAEAIREVVRRLAMARPDIAFTLAGEERAPVTWAAALPGAPGQLIRLGDILGADFRANAIEVRAEREGVVVEGFAASPALTKANALGQYLFVNGRPVRDKLILGAVRAAYSDYLPRDRHPVVALFVTLDSREVDANVHPAKTEVRFRNAGLVRALIVHALKDGLAREGRRTAANSAGSVISTFRPASMPPANWDWRASPSYPVGGSAAPSFAERAQAAFDVGAPSADIRPTEVTPDLLDRPLGAARTQIHETYIVSQTRDGLIVVDQHAAHERIVYERLKASLEANGVQRQILLIPDIVEMDEATVERLVARGEELAKFGLVIESFGPGAVAVRETPSLLGKTDAGGLLRDLAEHMAEWDEALPLERRLMHVAATMACHGSVRAGRVLKPEEMNALLREMEATPNSGQCNHGRPTYVELTLTDIEKLFGRR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: MURQ_SALCH
Sequence: MNLGTLVSETRNPQTMDLDALPTPELVKRFNEQDTRVAEAVKATLPDVARAVDAAAAALKSGGRIIYMGAGTSGRLGVLDASECPPTFGVPHGLVVGLIAGGPGALLKAVEGAEDSQQAGEDDLVALNLQEQDLVVGLAASGRTPYVIGGLRYARQSGCTTVAVSCNPDSPIAREANIAISPVVGPEALTGSTRLKSGTAQKMVLNMISTGAMVKFGKVYQNLMVDMKATNVKLVDRACRMVVEATGIGREEAEALLKQTDFEVKPAILMALTGLDAAAAREKLAAHQGFLRAALEH
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: RL7_METPB
Sequence: MADLAKIVEDLSSLTVLEAAELAKLLEEKWGVSAAAAVAVAAGPAGGGAAAPAAEEQTEFTVVLASAGDKKIEVIKEVRAITGLGLKEAKDLVEGAPKPVKESVAKDEAEKLKAQLEKAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: NCAP_I96A0
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVAPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMESSRPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: PTH_RICPR
Sequence: MILVIGLGNPGTEYQYTRHNIGFIAIERIASKYHLSFSIKKKFNCEIAEAVIDRQKIIFIKPTTYMNLSGKSVILVKTYYNIKYEKVFVIHDDIDLEIGRIKFKTGGGNGGHNGLKSIDVVIGNHYNRIRIGIGRPKNNHDVADYVLNNFSESEYKIAMQSIDNIANNFGLILEHKLAEFTNKIV
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_LEVBA
Sequence: MRYQRPKGTADILPGDSQTWQFVEATARQLFANYRFEEIRTPMFENFEVFSRTSGDTSDIVTKEMYDFKDKGDRHLSLRPEGTAGVVRAFVENKLYGPETQKPYKVYYMGPMFRYERPQSGRQRQFHQIGVEAFGSDAPELDVEVIALGMNLLGKLGLTHLRLAVNTLGDQETRTAYRQALIDFLEPHFDELSEDSKVRLHKNPLRVLDSKDKHDQELVADAPSILDFLTPTATAHFDRVKASLDALGIDYDVDATMVRGLDYYNHTIFEIMADSPALGEGYTTVLAGGRYNGLVEELGGPEMPGVGFGLGVERLVLLMQAEQVAIPDNHPLDVYVVGIGDQTSLATLKIVQAIRQSGLTADRDYLDRKPKAQFKTANRLNAAYTLTIGEQELADHTANLKSMATGEEISVPLADIYQDFQNVVATKFTAK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSST1_CONBE
Sequence: MEMAYWVMVMMMVWITAPLSEGGKLNDVIRALAPDDVTPQFILRSLISRRRSDSDVREVPVCSWKICPP
What is the function of this protein?
Moderately activates human somatostatin receptors (SSTR) with a preferential activation of SSTR1 and SSTR4.  In vivo, does not cause behavioral changes in mice within a few minutes of intracranial injection, but causes a progressive loss of movement thereafter.  Four to five hours after injection, mice recover, even with the highest dose tested.  Shows antinociception and antihyperalgesia activities in two mouse models of acute pain, most probably by acting outside the central nervous system.
What are the official names of this protein?
Consomatin Be1, ConSST Be1, Somatostatin-related peptide, SSRP.
What is the protein family that this protein belongs to?
Belongs to the conotoxin C superfamily. Consomatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NAL4A_MOUSE
Sequence: MASFFSDFGLMWYLEELNKKEFVKFKEFLKQEVLQLGLKQVSWTEVKKASRQDLASLLLKHYEEKPAWDMTFRFFQKINRKDLIERAKREIDGCPKLYRAHMKTKMTHDSSRAFTISIQNFLKEKFTEDDYDCFENLFQSKGTESKPQVVFLSGGAGVGKTLMLKRLMLAWIESPVFLHKFSYIFYFCCREVKQLKTASLAELISREWPGPSAPIEEILSKPEKLLFIIDSLEGMECDLFKWESELCDNCTEKQPVNVLLSSLLRRKMLPESSLLISATPESFEKMENRIEYTHVKIIKGLKERNIKMSFHRLFQDRNRAHEAFSLVRENEQLFTVCQVPVLCWMVATCLKEEIEKGRDPVSICRCTTSLYTTHIFNLFIPQNAHSPSKKSQDQLQGLCSLAAEGMWTDTFVFGEEALRRNGIMDSDIPILLDIGMLINIRESEKSYIFLHPSVQEVCAAIFYLLKSHVDHPSQEVKSIEKLMFAFLKKVKVQWIFFGSFIFGLLHESEQKKLEAFFGHQLSQEIKRQLYQCLETISGNEELQEQIDGMKLFYCLFEMDDDTFLVEAMNCMEQINFVAKDYSDVIVAAHCLKHCFTLKKLSFSTQNVLSGAQEHSYMERLLTAWNHICSVFIISKDIQELRMKDTNLSESAFSVLYNNLKYHNYTLNVLVANNVFFVCEKYLFFELIQNCNLQHLNLSLTILSHSDVKLLCDVLSQAECNIEELVVAACSISSDDCKVFASVLISNKTLKHLNLASNTLDKGIASLCKSLCHPDCILEHLVLANCSLNEKCWDYLSEVLRRNKTLSHLDISSNDLKDEGLKVLCRALTLPDSVLKSLSLRHCLITISGCQDLAEVLRNNQNLVSLQVSNNKLEDTGVKLLCDAIKHPNCHLEDLGLEACELTGACCEDLASTFTQCKTLWAMNLLKNALDYNGLVVLCEALKQQTCATYVLGLQITDFDTETQAFLVAEQEKNPCLRILSSL
What is the function of this protein?
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 4A, NALP-ita.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
Protein: LEXA_BURPS
Sequence: MIKLTARQQQVFDLIRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAAGASRGIRLLGIDDAPHQLTLPHAALMQLSLPLVGRVAAGSPILAQEHISQHYACDPALFSSKPDYLLKVRGLSMRDAGILDGDLLAVQKRTEAKDGQIIVARLGDDVTVKRLKRRPGGVELIAENPDYENIFVKAGSAEFALEGIAVGLIRPGEF
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: DDL_MYCSJ
Sequence: MIARNQRTRVAVVYGGRSSEHAISCVSAGSILRNLDPERFDVVAVGITPDGSWVLTDGRPETLAITDGRLPEVSAESGTALALPADPGRRGELVSLSPAPAGEVLAAVDVVFPVLHGPYGEDGTIQGLLELAGVPYVGAGVLASAAGMDKEFTKKLLVAEGLPVGDHVVLRPGRANVTLDERERLGLPVFVKPARGGSSIGVSRVSDWAELPAAIEAARRHDPKVIVEAGIAGRELECGVLEYPDGRVDASTIGEIRVAGVRGREDGFYDFATKYLDDGAELDVPAKVEDDVADEIRRLAIRAFRAIDCQGLARVDFFLTDDGPVVNEINTMPGFTTISMYPRMWAASGVDYPTLLAAMVDTAVARGTGLR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.