PharMolix/UniProtQA huggingface dataset:
Protein: OCDH_MIZYE
Sequence: MTLKVCVCGGGNGAHTLSGLAASRDGVEVRVLTLFADEAERWTKALGADELTVIVNEKDGTQTEVKSRPKVITKDPQVAITGADVVILTVPAFAHEGYFQAMAPYVQDSALIVGLPSQAGFEFQCRDILGDKAAAVSMMSFETLPWACRIKEFGRKVEVLGTKSVLAASLIKGTAETVDPLSTLQKLHGAEPVFRLAKHFLEMLIMSYSFVHPAILYGRWGSWDGNPVSEAPLFYQGIDQATADMLTACSDECKAVGNAIMAACPGNDLSDVKDIYQWYLEYYHEDIQDDHDLYHAITTNKSYKGLVHPVKTVDGGVAPDFGNRYLTEDIPMGMIVFKGVAIAAGVPIPNNDKLITWAQEKIGKVYLVDGALTGKDVATTRCPQRYGFNTLNAILTGKKE
What is the function of this protein?
Catalyzes the reverse reaction of octopine dehydrogenation.  Acts on L-arginine in preference to other substrates (By similarity).
What are the official names of this protein?
Octopine dehydrogenase, OcDH.
What is the protein family that this protein belongs to?
Belongs to the lysopine/nopaline/octopine/opine/vitopine dehydrogenases family.
Protein: DPOL_TUHV2
Sequence: MSTVTFFNPYLCGPRKPRAPSAGEGGAEGAAAARARAASAPFLQIVPRGCLYDGERGLLKHNCALAPRMFFRDRPYVLSKDLVWPTLPPPAVPASTTERAPRAPAPSADLLFHMYDQAETVVSADSKELIHPGYRHRITPCGVVLRLFGRTADGASLCVNVFGQDAYFYCRYGDAQSLHDRLYRLSDTLELAPVFHVRVRRVQRCSIYGYGTRPFADLYLVACGNWHVLKKMGQCLLDEGVEVFEVGVSPLTRFLLDKKIPSFGWCRLRRWHARPAHGRLSTAELEVDCEVADVRGVDDVAWPLYRCLSFDIECLSGGGAFPVAENLDDVVIQISCVCYPVGGTEEQRAAFPVAERHLFTLGPCAPIPGVLVYEFPSEFELLCGFFTFFGRYAPEFVTGYNINNFDWRYLLTRAERVYRWPVAEYTRLRFGGRFCAYVPGGGGRQPGFRTAQTKVLITGTVVLDLYPVCMAKVSAPDYKLNTVCELYLGRQKEDLSYKELPRAFLSGDAGRARVGRYCVQDAVLVKELFEKLNYHYEAAAVARLARISLRKVIFEGQQIRIYTCLLEEAAARQMVVPTFRSGAQRGAAPGAGGGGGEETTYQGATVFEPTVGYHHAPVAVFDFASLYPSIIMAHNLCYSTWLRDDPGTPARPPETPARPPETPAAGPSGAAHAGGVPGATFRTPFRTPAGVPAAAAGGAGAGPPGGGAVSSASVGGRAAVSPSETPAEREPEPAPEDVFVVHVGQGVSYRFVRENVRASILSELLRRWLAQRRAVREAMRECEDETRRLLLDKEQLALKVTCNAFYGFTGFSQGMLPCLPVAASITTIGRDMLSRTSAYIEAHFAEPAFLARFFEPGDLPRADEPPPTVRVIYGDTDSVFVRFGGVRAGAIVARGEDLAAAVTEALFTEPVKLEFEKLFVALMMICKKRYIGRVFGSDALVMKGVDLVRKTACRFVKTVVRDVVELVFRDAAVAEAATRMSELTLEEMRRVGVPAGFHVLLQRLARARDDLFSGRVETAALVLSSVLSQDVSRYKQLNLPHLAVIRRLAARSEELPSVGDRVSYVLTAGPPDGRANAPNYELAEDPDYVAAHRVPIHAAKYFEQVVKAVTNTLYPVFPRGVVRRDRFLADLVPKRVYLGDEFKRHARPVEEEVCESERGGSGLLSSLDSSR
What are the official names of this protein?
DNA polymerase catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: KDM4A_PONAB
Sequence: MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELPPRAGNEEECPEDDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQEAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSVSSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPCMRKKGSTARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCGTDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIESALYRAIME
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (By similarity).  Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'.  Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues.  Demethylation of Lys residue generates formaldehyde and succinate.  Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity).
What are the official names of this protein?
Lysine-specific demethylase 4A, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, [histone H3]-trimethyl-L-lysine(36) demethylase 4A, [histone H3]-trimethyl-L-lysine(9) demethylase 4A.
What is the protein family that this protein belongs to?
Belongs to the JHDM3 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS2_ACIET
Sequence: MSVTMREMLEAGVHFGHQTRFWNPKMAPFIFGHRNKIHIINLEKSLPMFQEAQKFAKQLAANRGTILMVGTKRQARELVAEQAQRAGVPYVDQRWLGGMLTNFKTVKTSIKRLKDMKAQQEAGLESMSKKEQLMFSRELEKLEKDIGGIQDMAALPDAIFVIDVGYHKIAVSEAKKLGIPLIGVVDSNHSPEGIDYVIPGNDDSAKAVALYARGIADAILDGRANAVTEVAKAVAAEGSDEFVEVDENAA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RS6_CHLPD
Sequence: METKKLYECTVIIDGGLQDEVIAAAMEMVQKVIADKGGSISSVLEVGRRKTAYPINKKTIGYYAHIEFTAGTSVIAEIEKVLRYEEALMRYLIIHLTSALLEMRKRVEKYSVVIGSPEDNAGNEVEASEGESK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MCP2_ECOLI
Sequence: MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVATSRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLTNKPQTPSRPASEQPPAQPRLRIAEQDPNWETF
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.  Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.
What are the official names of this protein?
Methyl-accepting chemotaxis protein II, MCP-II, Aspartate chemoreceptor protein.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Found predominantly at cell poles.
Protein: SECF_METTH
Sequence: MGETLKVIVLIDRILKSYRPLIAIPAAITVIALLLVVFNGLNESVDLKGGALAELTLEKSVTQAELESLLREKLGTGDIKVLSIRGERVTVQFGTDMDVVKVSEALRGTATINSYKAVGPVLSKQAMNQIYWAIGFAFLFMSVTVFIIFRDPVPSLAVILAAASDIIIAVGGMSLFGIPLSLASVGAILMLIGYSVDTDILLTTRVLKRRKGTINERALGAMKTGVTMSIAAIASMAALYLVTVFVMPEARVLSDIAAVLIIGLLADILTTWLMNLGILRWYLEVRS
What is the function of this protein?
Involved in protein export.
What are the official names of this protein?
Protein-export membrane protein SecF.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecF subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DIVIB_STRPN
Sequence: MSKDKKNEDKETLEELKELSEWQKRNQEYLKKKAEEEAALAEEKEKERQARMGEESEKSEDKQDQESETDQEDSESAKEESEEKVASSEADKEKEEKEEPESKEKEEQDKKLAKKATKEKPAKAKIPGIHILRAFTILFPSLLLLFVSAYLLSPYATMKDIRVEGTVQTTADDIRQASGIQDSDYTINLLLDKAKYEKQIKSNYWVESAQLVYQFPTKFTIKVKEYDIVAYYISGENHYPILSSGQLETSSVSLNSLPETYLSVLFNDSEQIKVFVSELAQISPELKAAIQKVELAPSKVTSDLIRLTMNDSDEVLVPLSEMSKKLPYYSKIKPQLSEPSVVDMEAGIYSYTVADKLIMEAEEKAKQEAKEAEKKQEEEQKKQEEESNRNQTTQRSSRR
What is the function of this protein?
Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
What are the official names of this protein?
Cell division protein DivIB.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. DivIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: ARGC_PROMS
Sequence: MNVAIVGATGYGGIQAVNLLKKIKKYKISFLGGNKTSGSKWNENFPFIYLDNDPYIEEISVDNISKNADVALLCLPNGLSSTLTRKLLDRGLKVIDLSADYRYKSLDEWKNVYSKEAAIYKRNDDDLCKEAVYGLPEINKEAISKGRLIACPGCYPTSALIPLVPYLSQGIIENEGIVIDSKSGTSGGGREPNQKLLLSECGEGLSAYGLINHRHTSEIEQVASLISGNKIELLFTPHLVPISRGMHSTIYGRLRDPGLTSDDCRILLDNYYRNFKNIKVLPVDTFPSTKWVKNTNQIFLSVKVDIRNGRIIILSAIDNLLKGQTGQAIQNLNLMSGFSMDEGLDLTNNFP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCSK5_RAT
Sequence: MDWGWGSRCCRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTRICVSSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICGKCSENCKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFFSGHDCQPCHRFCATCAGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGMCQMGAICKDGEYIDEQGHCQICDASCAKCWGPTQDDCISCPITRVFDDGRCVMNCPSWKFELKKQCHPCHHTCQGCQGSGPSNCTSCKAGEFQDSEYGECMPCEEGCVGCTVDDPGACTSCATGYYMFERHCYKACPEKTFGEKWECKACGTNCGSCDQHECYWCEEGFFLSSGSCVQDCDPGFYGDQELGECKPCHRACETCTGLGYNQCSSCPEGLQLWHGTCIWPTWPHVEGKVWNEAVPTEKPSLVRSLPQDRRKWKVQIKRDATRQYQPCHSSCKTCNGSLCTSCPAGTYLWLQACVPSCPQGTWLSVRSSSCEKCAEGCASCSGDDLCQRCLSQPSNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCKGNATSCHSCEGDFVLDHGVCWETCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHHSCPKNFYPDMRQCVPCHKNCLGCNGPKEDDCKACADTSKVLHNGLCLDECPKGTYKDEVNDECRDCPESCLICSSAWTCLTCREGFTVVQDVCTAPKECAAIEYWDVGSHRCQPCHRKCSRCSGPSENQCYTCPRETFLLNTTCVKECPEGYHTDKDSHQCVPCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCEKCDKSCKTCRGPQPTDCQSCDTFFFLLRSKGQCHLACPEHYYADQHAQTCERCHPTCDKCSGKEAWNCLSCVWSYHLLKGICTPECIVGEYRDGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLQMDDSRCLRCCNASHPHRSQDCCDCQSSTDECILPASDDTVFHEHTKTALLVTSGAMLLLLLGAAVVVWRKSRSQPVAKGRYEKLAEPTVSYSSYRSSYLDEDQVIEYRDRDYDEDDEDDIVYMGQDGTVYRKFKYGLLDEAEDDELEYDDESYSYQ
What is the function of this protein?
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif.  Likely functions in the constitutive and regulated secretory pathways.  Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.  May be responsible for the maturation of gastrointestinal peptides.  May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 5, Proprotein convertase 5, PC5, Proprotein convertase 6, PC6, Subtilisin/kexin-like protease PC5, rPC5.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
[Isoform PC5A]: Secreted. Note=Secreted through the regulated secretory pathway. SUBCELLULAR LOCATION: [Isoform PC5B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.
Protein: MURC_ECOUT
Sequence: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEEQHD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_BACCR
Sequence: MRIAVIGAMEEEVRILRDKLEQAETETVAGCEFTKGLLAGHEVILLKSGIGKVNAAMSTTILLEKYKPEKVINTGSAGGFHHSLNVGDVVISTEVRHHDVDVTAFNYEYGQVPGMPPGFKADEALVALAEKCMQAEENIQVVKGMIATGDSFMSDPNRVAAIRDKFENLYAVEMEAAAVAQVCHQYEIPFVIIRALSDIAGKESNVSFDQFLDQAALHSTNFIVKVLEELK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: SMN_FELCA
Sequence: MAMGGGSGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDISEASDKPKGTPKRKPAKKNKSQKKNTTAALKQWKVGDKCSAIWSEDGCVYPATIASIDFKRETCVVVYTGYGNREEQNVSDLLSPASAVDNNVEQNAQENENESQISTDESENSCRSPGNKSNNVKSKATSWNSFLPPPPPMPGAGLGPAKPGLKFNGPPPPPPPPPHFLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFKQNQKEGRCSHFN
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate.  Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP.  Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits.  Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development.  Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination.  May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
What are the official names of this protein?
Survival of motor neuron protein.
What is the protein family that this protein belongs to?
Belongs to the SMN family.
What are the subcellular locations of this protein?
Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with actin and at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. Colocalizes with FMR1 in cytoplasmic granules in the soma and neurite cell processes (By similarity).
Protein: NUOH_RALPJ
Sequence: MIESITSFGTATFGGWWPLVWTLVRAVCIILPLLLCVAYLILWERKLIGWMHVRLGPNRVGPMGLLQPIADVLKLLLKEVMVPSAVSRGMYIIAPLMVLMPAVAIWAVIPFQAEAMVSNINAGLLYVMAISSVGVYGVILAGWASNSKYAFLGAMRASAQMISYEIAMGFALVTVLMVTGSLNLSDIVNSQNRGFFAGHGINILSWNWLPLLPMFGVYFISGVAETNRHPFDVVEGESEIVAGHMIEYSGMAFALFFLAEYINMIVISALTATLFLGGWASPIDAPVLNWIPGFFWLLIKVFLLLSVFIWLRASFPRYRYDQIMRLGWKIFIPLTVGWLVVVAIWLVSPWNIWK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CHX6B_ARATH
Sequence: MDAENATWRKEFMWNNDEKRAEMGTKMFCDVSPHIMLNSHGVAEKMASGSKGMDFWEYPLPQLEIIILSIFLLWRLFDMLFKKLGVPIPKFTSMMLVGAVLSEMFGSMQIPCLKHIFIHYNQYMTKVPDTIGAFAFVLDWFLRGVTTDVGIMKKSGTKSVVIGITSMIIPWQIGKLLYSSREKSSILTMTEMEYTVMTFTMSMTPFTCVNMLLTDLKIVHTDFGQIAQSAGMVTDLLAFFLTVSAYVSRDETQGVKMGLAFMAFFIFVYLVRQFMLWVIRHTPEGAPVKNVYLYIGLLLAYLSYLYWSRFLFFGPLGAFALGLAVPNGPPLGSVFIQKFDSFNEGIFLPLFGSLSMIKLDWSFLRKEFGNGRHLHGHMYECFSFLPIVYIAKFATSFLAALATKIPLRDSIILGVIMGTKSSFELGYVLTAFEKDRISLEVLSLLGVYILVNSLLTPMAIHFLYDRSKRFVCYGRRNLKEKPEMQTLVCINKPDNITSMISLLRATSPSKDSPMECCVLHLIELLGQATPTFISHQLQKPKPGSRSYSENVISSFQLFQEVYWDSASINMFTSLTSAKEMHEQICWFALSQGSNLILLSFHRTWEPNGNVIISDDQTLRSLNLNVLKRAPCSVGIFVYRKPIWQTKALESPCRVCLIYVGGNDDKEALALADHMRGNQQVILTVLRLIPTSYADESSLRIHSQMVDMNRHEDQRPGDKSTIIDWTVGDGTETSKILHSVSYDYDLFIVGRRSGVGTTVTRGLGDWMEFEELGVIGDLLASEYFPSRASVLVVQQQE
What is the function of this protein?
May operate as a cation/H(+) antiporter.
What are the official names of this protein?
Cation/H(+) antiporter 6B, Protein CATION/H+ EXCHANGER 6b, AtCHX6b.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ZN426_MOUSE
Sequence: MAAPASSHGPSEDSGCLQERKIAAEMMLVDCLTDDQELVSFEDVIVDFTQEEWSSLNPDQRNLYRDVMLENYQNLATVGYQLIKPSLISWLEQEEFSKGQKIVFPEWKLQLETKCSAFQQEFLRGNISSRMQMQTGINRGRELCDGTQYGDFFSELSPLRTDMKTQPAQDNYGCSQYRKDFLMLQRKNCAGEKLSEFSQSEETGMTPVKEKIDTQEKGFECSDCGKSFMSQSHLQTHQRTHSGDKLYEWNECGRSFINSRLAVLIETLNAKKPHRCKECGKGYRYPAYLNIHMRTHTGEKPYECKECGKAFNYSNSFQIHGRTHTGEKPYVCSQCGKAFTQHSGLSIHVRSHTGDKPYGCKECGKAFLTSSRLIQHIRTHTGEKPFVCVKCGKAFAISSNLNGHLKLHAEEKTCECKICGKAFGYLSCLNNHMRTHNAKKSYTCKECGKAFNYSTHLKIHMRIHTGEKPYECKQCGKAFSHSTSFQIHERTHTGEKPYECKECGKAFICPSSFRIHEISHTHTEEKPYKCQQCGKAYSHPRSLRRHERIH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 426.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARP1_METRA
Sequence: MNQSLTPSAGTDSKTGSSKAISFQDYLDLSTLDWARLRAILAPALYVDYTKIGKEKWDAMSADDFMAMVSNDDFLGDPCVKTQHLIGATYWERVSESKVIGHHQLRAAHQVYTSPDLKTVKLRGHSHATNEHYYVKSSGVWKFAGLKPEVRWNEYKFEEVFKGSYTQSEKHS
What is the function of this protein?
Scytalone dehydratase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster (PubMed:29958281).  The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified (PubMed:29958281).
What are the official names of this protein?
Scytalone dehydratase-like protein Arp1.
What is the protein family that this protein belongs to?
Belongs to the scytalone dehydratase family.
Protein: FDHD_SALG2
Sequence: MNNILSEEVLNVTDFTTSRQLTLWKREDLQSPQLDDVAEEVPVALVYNGISHVVMMASPKDLTHFAMGFSLSEGIIDSPREIYGMDVVPSCNGLEVQIDLSSRRFMGLKARRRALAGRTGCGVCGVEQLNDIGKPVQPLPFSQTFNLGNLDRALKHLNDFQPTGKLTGCTHAAAWVMPSGELAGGHEDVGRHVALDKLLGRRATEGEEWRQGAALVSSRASYEMVQKSAMCGVEILFAVSAATTLAVDVAERCNLTLVGFCKPGRATIYTHPQRLIAD
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_PASMU
Sequence: MQHYHFSHSLLAQQEKPYRFPCPAKLNLFLYINGKRQDGYHELQTLFQFVDFGDWLDIEVREDNEICLTPELPSLKNEDNLVYRAAKLLQQKTNCALGANLTLDKILPMGSGLGGGSSNAATALVALNYLWNTQLSTKQLAKLGLMLGADVPIFVHGHAAFAEGVGEKITYCEPKEKWYVVLKPNVSISTATVFSDPDLIRNTPKQSLEQLLNQKYANDCEKVVLNHYPEVEEILHRLLQYAPSRLTGTGACVFAEFNDEESAQLAFQTIPKNYFGFVAQGLNKSPLHNMLAKIS
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: YFDI_ECOLI
Sequence: MNKAIKVSLYISFVLIICALSKNIMMLNTSDFGRAIKPLIEDIPAFTYDLPLLYKLKGHIDSIDSYEYISSYSYILYTYVLFISIFTEYLDARVLSLFLKVIYIYSLYAIFTSYIKTERYVTLFTFFILAFLMCSSSTLSMFASFYQEQIVIIFLPFLVYSLTCKNNKSMLLLFFSLLIISTAKNQFILTPLIVYSYYIFFDRHKLIIKSVICVVCLLASIFAISYSKGVVELNKYHATYFGSYLYMKNNGYKMPSYVDDKCVGLDAWGNKFDISFGATPTEVGTECFESHKDETFSNALFLLVSKPSTIFKLPFDDGVMSQYKENYFHVYKKLHVIYGESNILTTITNIKDNIFKNIRFISLLLFFIASIFIRNNKIKASLFVVSLFGISQFYVSFFGEGYRDLSKHLFGMYFSFDLCLYITVVFLIYKIIQRNQDNSDVKH
What are the official names of this protein?
Uncharacterized protein YfdI.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.