PharMolix/UniProtQA huggingface dataset:
Protein: MSCL_PROMH
Sequence: MAFFKEFREFAMKGNVVDMAVGVIIGAAFGKIVSSLVADVIMPPLGLLIGGIDFKQFSLVLREAHGDIPAVILNYGAFIQTVFDFAIVAFAIFCAIKLINKMRRQEEEQPKAPPAPSAEETLLTEIRDLLKNQQK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GPMA_CUTAK
Sequence: MTAKLILLRHGESEWNSKNLFTGWVDVDLNEKGEGEARHAADLLKQENLLPDIVHTSLLRRAIHTAYLALDGCDRHWIPVHRSWRLNERHYGALQGLNKAETKEKYGNDQFMAWRRSYDVRPPDLDRDSEFSQFHDPRYADIPASERPVAECLKDVVARMVPYFTSDIAADLKDGKTVLVAAHGNSLRALVKHLDEISDEDIAGLNIPTGIPLFYELDDNLKPVTRGGRYLDPEAAAAGAKAVANQGNK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: V4_SPTNK
Sequence: MLGGDTPYDFAEKKYITRMNKDEINYLMTPVPKAVYKNRKSPIDLPFFNGKKQDAYGHLLDNVEKPIYKSGGQNVYANSWNGRTYGKKPAKAQPTDRLICEFCGKTYTRSNRSTHRKTEVCKAYQSMNKKLKDVLLRTD
What are the official names of this protein?
Uncharacterized protein V4.
Protein: PI4KB_MOUSE
Sequence: MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGTPLELVNGDGVDNEIRCLDDPPAQIREEEDEMGAGVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFYFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
What is the function of this protein?
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP).  May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity).  Involved in Golgi-to-plasma membrane trafficking (By similarity).
What are the official names of this protein?
Phosphatidylinositol 4-kinase beta, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
What are the subcellular locations of this protein?
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment (By similarity).
Protein: IL2_DASNO
Sequence: MYKMQLVACIALSLVLITNSAPTSSSTKETQQQLEQLLLDLKMLSKMVNNKDLKLPRMLTFKFYMPKRVTELKHLQCLVEELKPLENVLNLAQSQMSQLEHNGDLISNINITVLELKGSETTFMCDYDDEAATIVEFLNKWIIFCQSIISKRLDN
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRH_THEP1
Sequence: MRVLVKLSGEALSGEGGRGFDPERVNYIVTEIKSVVEEGFKIGIVVGAGNLFRGVELKNLTMARADQIGLLGTVMNSVYLKDIFERSGLKARIYSQIVNLPDVERVNYDSIESALRENSILIFAGGTSNPFFTTDTAAVLRAQEMKAKLVVKATKVDGVYDKDPKKFPDAKKIPHLTFSEAMKMGLKVMDAEAFALCKKLGITVKVINFFEPGTLLKALKGEDVGSTVVPD
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RH25_ORYSJ
Sequence: MAAGDLLLRTQSGLPVLARAFPSCLCLRVPARRRRGAPPLTAAKVDVADAVGRRVRSGGAAVPKRRRSRRDAEEEEEEGLAFSRVVTGRGRGVREEGVAEGEAPEFDAAKSGDESGGVDGSYLSDTRFDQCTISPLSLKAVKDAGYERMTQVQEATLPVILQGKDVLAKAKTGTGKTVAFLLPAIEVLSALPNSRRDQLRPSINLLVMCPTRELAIQVAVEAKKLLKYHRSLGVQVVIGGTRLTQEQRSMQANPCQILVATPGRLKDHVENTPGFSTRLKGVKVLVLDEADRLLDMGFRRDIERIIASVPKERQTLLFSATVPEEVRQISHIAMKKNYKFINTVKDGDEETHAQVSQMFMIAPLDLHFSILYDVLKKHVAEDADYKVIIFCTTAMVTKLVAEILSQLRLNIREIHSRKSQSARTKVSDEFRKSRGLILVSSDVSARGVDYPDVTLVIQVGVPADRQQYIHRLGRTGRKGKEGQGLLLLAPWEKYFLSSIKDLSISEATVPSVDSSTQTIVKDAVRKVEMRSKECAYQAWLGYYNSNKTIGREKSRLVKLAEEFSQSMELSVPPAIPKQILRKMGLNNVPGLRST
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 25.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family.
Protein: SESN1_MOUSE
Sequence: MRLAAASNEAYAASLAVSELLSCHQCGGDRGQDEELGIRIPRPLGHGPSRFIPEKEMLQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVSDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMQVNSAGNASVSDSFFEVEALMEKMRQLQECREEEEASQEEMASRFEMEKRESMFVFSSDDDEVTPARDVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT
What is the function of this protein?
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex.  In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling.  Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25259925).  This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses.  May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1.  Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein.  Was originally reported to contribute to oxidative stress resistance by reducing PRDX1.  However, this could not be confirmed (By similarity).
What are the official names of this protein?
Sestrin-1.
What is the protein family that this protein belongs to?
Belongs to the sestrin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RR7_SOLTU
Sequence: MSRRGTAEKKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIRGVTPDITVKARRVGGSTHQVPIEIGSTQGKALAIRWLLAASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CAHM1_HUMAN
Sequence: MMDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCLPGYNAAYSAGILLAPPLVLFLLGLVMNNNVSMLAEEWKRPLGRRAKDPAVLRYMFCSMAQRALIAPVVWVAVTLLDGKCFLCAFCTAVPVSALGNGSLAPGLPAPELARLLARVPCPEIYDGDWLLAREVAVRYLRCISQALGWSFVLLTTLLAFVVRSVRPCFTQAAFLKSKYWSHYIDIERKLFDETCTEHAKAFAKVCIQQFFEAMNHDLELGHTHGTLATAPASAAAPTTPDGAEEEREKLRGITDQGTMNRLLTSWHKCKPPLRLGQEEPPLMGNGWAGGGPRPPRKEVATYFSKV
What is the function of this protein?
Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity).  Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity).  Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (By similarity).  Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080).  Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817).  Acts as an activator of the ERK1 and ERK2 cascade (PubMed:23345406).  Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PubMed:21574960).  May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (PubMed:18585350).
What are the official names of this protein?
Calcium homeostasis modulator protein 1, Protein FAM26C.
What is the protein family that this protein belongs to?
Belongs to the CALHM family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum (PubMed:18585350). Localizes to the basolateral membrane of epithelial cells including taste cells (By similarity).
Protein: RPOC_AFIC5
Sequence: MNQEIMNLFNPTTPAQVFDQIRISIASPEKILSWSYGEIKKPETINYRTFKPERDGLFCARIFGPIKDYECLCGKYKRMKYKGIICEKCSVEVTLSRVRRERMGHIELAAPVAHIWFLKSLPSRIGLLLDMTLKDLERILYFEYYVVLEPGLTALKDRQLLSEEEYLKAQDEYGQDSFTAMIGAEAIRELLRGLDLEKLEAQLRADMAETDSDIKHKKFAKRLKIVEAFRNSGNKPEWMIMTVVPVIPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLMELRAPDIIIRNEKRMLQEAVDALFDNGRRGRVITGANKRPLKSLADMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYSRLDAKGLSTTVKQAKKLVEKERPEVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPTLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSLEAQLEARVLMMSTNNILHPANGQPIIVPSQDIVLGLYYLSIMREGLAGEGKVYGEMAEIEHALYSKVIHLHTKIKYRWHGVGEDGKPVTKWYETTAGRVMLGQVLPNHPKIPFDAINKLMTKREISGVIDQVYRHCGQKETVIFCDRIMALGFHNAFKAGISFGKDDMVVPQGKWKVVDDTRSMAKEFEQQYNDGLITQGEKYNKVVDAWSKATEKIADEMMKEISSVKKTTKGNEAQINSIYMMAHSGARGSPAQMRQLAGMRGLMAKPSGEIIETPIISNFKEGLSVLEYFNSTHGARKGLADTALKTANSGYLTRRLVDVAQDCIINASDCGTNLGIKMRAIVDAGTVVASLGSRILGRTACEDIREPSTNNVIVPRGTLMEESHVDAIQRAGVQEVKIRSALTCELVNGICAMCYGRDLARGTPVNHGEAVGVIAAQSIGEPGTQLTMRTFHIGGAAQINEQSFVESNFDGKVTIRNRGIATNSEGASVAMVRNMVVAIVDADGTERVTHRVQYGARMRVDEGDTIKRGQRIAEWDPYTRPILTEVEGTIGFEDLVEGQSISETLDESTGIAKRVVIDWRSTGRGADLRPAIVVKGKDGKVLKLQRGGDARYMLSVDAILSVDIGSQVKPGDILARISTESAKTRDITGGLPRVAELFEARRPKDAAIIAETAGTIRFGRDYKNKRRISIEPTDKTEEPREYLIPKGKHIHLQDGDIVEKGDFIVEGNPAPHDILAIKGIEELAAYLVNEIQEVYRLQGVLINDKHIEVIVRQMLQKVEVTDQGDTDMISGEQVDKIEFDQNNDKAKEEGKKPATGTPVLLGITKASLQTRSFFSAASFQETTRVLTEAAVNGKVDPLEGLKENVIVGRLIPAGTGASMAKIREVAMKRDKLIQDEREKQAAITPAAPEAEPLALPPAE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: Y4337_SERP5
Sequence: MSQRAIGAGYELQARHYLERAGLTFCAANVALRGGELDLIMRDGQTWVFVEVRYRRSDAFGGAAASVTYRKQQRLLHAAAVWLAGRGASFDTSSCRFDVLAITGSQLEWIPNAFNAD
What are the official names of this protein?
UPF0102 protein Spro_4337.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: Y1031_BRUAB
Sequence: MTALILKRVAQAIPVMLIVAILTFLLMKLLPGDPAILIAGDGASPETVERIRVELGLDQPTVVQLGQWLWNLFHFDLGRSFLLSQPVSQAIAERLPVTISLALLAFAITIPVGIIMGVVAAYLRDSWFDTGVMSLALLGVSVPSFWLAILAVILFSVTLGWFPSAGYVPFLDSPLGWLRSLILPASILALFQIGYLARMTRSEMLEVMDQDYIRTARSKGVSEYSVLSTHAFRNALVSVLTVSGYIFSLLIGGSVVIEQIFALPGLGRLLVQAILARDLPVVQGTMLFLGFLFVAINVLVDILYTIADPRVRYD
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Putative peptide transport system permease protein BruAb2_1031.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TM252_HUMAN
Sequence: MQNRTGLILCALALLMGFLMVCLGAFFISWGSIFDCQGSLIAAYLLLPLGFVILLSGIFWSNYRQVTESKGVLRHMLRQHLAHGALPVATVDRPDFYPPAYEESLEVEKQSCPAEREASGIPPPLYTETGLEFQDGNDSHPEAPPSYRESIAGLVVTAISEDAQRRGQEC
What are the official names of this protein?
Transmembrane protein 252.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: 3DHQ_CANAL
Sequence: MVKKVLLINGPNLNLLGTREPEKYGTTSLSDIEQAAIEQAKLKNNDSEVLVFQSNTEGFIIDRIHEAKRQGVGFVVINAGAYTHTSVGIRDALLGTAIPFIEVHITNVHQREPFRHQSYLSDKAVAVICGLGVYGYTAAIEYALNY
What is the function of this protein?
Is involved in the catabolism of quinate.  Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.
What are the official names of this protein?
Catabolic 3-dehydroquinase, cDHQase, 3-dehydroquinate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: RBS1_SOLTU
Sequence: MASSIVSSAAVATRSNVAQASMVAPFTGLKSAASFPVTKKNNNVDITSLASNGGRVRCMQVWPPINMKKYETLSYLPDLSDEQLLKEVEYLLKNGWVPCLEFETEHGFVYREHNSSPGYYDGRYWTMWKLPMFGCTDGTQVLAEVQEAKNAYPQAWIRIIGFDNVRQVQCISFIAYKPEGY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic 1, RuBisCO small subunit 1, Ribulose bisphosphate carboxylase small chain C, chloroplastic, RuBisCO small subunit C.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYI_SHIBS
Sequence: MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYANGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQEYGKPGEKFTAAEFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHKGAKPVHWCVDCRSALAEAEVEYYDKTSPSIDVAFQAVDQDALKAKFAVSNVNGPISLVIWTTTPWTLPANRAISIAPDFDYALVQIDGQAVILAKDLVESVMQRIGVTDYTILGTVKGAELELLRFTHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDYVIGQKYGLETANPVGPDGTYLPGTYPTLDGVNVFKANDIVVALLQEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQWFVSMDQKGLRAQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHKDTEELHPRTLELMEEVAKRVEVDGIQAWWDLDAKEILGDEADQYVKVPDTLDVWFDSGSTHFSVVDVRPEFAGHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADSYRRIRNTARFLLANLNGFDPAKDMVKPEEMVVLDRWAVGCAKAAQEDILKAYEAYDFHEVVQRLMRFCSVEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTADEVWGYLPGEREKYVFTGEWYEGLFGLADSEAMNDAFWDELLKVRGEVNKVIEQARADKKVGGSLEAAVTLYAEPELAAKLTALGDELRFVLLTSGATVADYHDAPADAQQSEVLKGLKVALSKAEGEKCPRCWHYTQDVGKVAEHAEICGRCVSNVAGDGEKRKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR16_ADICA
Sequence: MVKLRPKQCGRKQRTYRIVAIESQSRQEGKVIKEVEFYNPRREETQLDILAITTLCGSGVKLTETVCNIFRRATFKIT
What are the official names of this protein?
30S ribosomal protein S16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IRAM_CITK8
Sequence: MEWSVENNLVCPTTGTAFALTSGAENLKFILWYKGDYFLRTGSVISPEDSGVLANGKKRNIKILHVFPYSNALWASFHNRIDCPGNGVVTINHCARQQQCVFTLCPYGARTVTG
What is the function of this protein?
Involved in the stabilization of the sigma stress factor RpoS.
What are the official names of this protein?
Anti-adapter protein IraM.
What is the protein family that this protein belongs to?
Belongs to the IraM/RssC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPG2_ARATH
Sequence: MHCFPCFSSPKNKKSSTTNETNDNNEPKPDDRRRAEETEEIEQSEGTSLKIFTFRELATATKNFRQECLLGEGGFGRVYKGTLKSTGQVVAVKQLDKHGLHGNKEFQAEVLSLGQLDHPNLVKLIGYCADGDQRLLVYDYISGGSLQDHLHEPKADSDPMDWTTRMQIAYAAAQGLDYLHDKANPPVIYRDLKASNILLDDDFSPKLSDFGLHKLGPGTGDKMMALSSRVMGTYGYSAPEYTRGGNLTLKSDVYSFGVVLLELITGRRALDTTRPNDEQNLVSWAQPIFRDPKRYPDMADPVLENKFSERGLNQAVAIASMCVQEEASARPLISDVMVALSFLSMPTEDGIPTTVPILSFKDKSMSIALSRHDSNLVSPPPELATEDDKSSTSSGEESSLESEKESVSKNEYKKKHEEEDSSMESDDESDSNSEHEKDQPPKPIDEKNQAQSLKIKYRYSWEDIDVNDERLSSKSSQKSNDESTSSRYDSDRDQDEKGKEEEEEEEAEEKHTHIEHIDSSKTDDDQSVYFDNDDDSGDDNGGSLHRIKSDVAIDSIKE
What is the function of this protein?
Involved in pollen tube guidance into micropyle.  Participates in perception of the ovule-secreted peptide signal LURE1.
What are the official names of this protein?
Receptor-like kinase LIP2, Protein LOST IN POLLEN TUBE GUIDANCE 2, AtLIP2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: PHOL_ECOLI
Sequence: MNIDTREITLEPADNARLLSLCGPFDDNIKQLERRLGIEINRRDNHFKLTGRPICVTAAADILRSLYVDTAPMRGQIQDIEPEQIHLAIKEARVLEQSAESVPEYGKAVNIKTKRGVIKPRTPNQAQYIANILDHDITFGVGPAGTGKTYLAVAAAVDALERQEIRRILLTRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALFEMLGFEKVEKLIERNVIEVAPLAYMRGRTLNDAFIILDESQNTTIEQMKMFLTRIGFNSKAVITGDVTQIDLPRNTKSGLRHAIEVLADVEEISFNFFHSEDVVRHPVVARIVNAYEAWEEAEQKRKAALAAERKREEQEQK
What are the official names of this protein?
PhoH-like protein.
What is the protein family that this protein belongs to?
Belongs to the PhoH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLF18_ARATH
Sequence: MMNNMKLLIIAVMIISAALLPALVVGSRPVKCDNCMDGGEKEEIMKMSSGVDVSHRILQAKRFIDYEALKKNLPAKPDGKPDKPDNKYRRGCSAATGCYRFTN
What is the function of this protein?
Cell signaling peptide that may regulate plant stress, growth, and development.  Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
What are the official names of this protein?
Protein RALF-like 18.
What is the protein family that this protein belongs to?
Belongs to the plant rapid alkalinization factor (RALF) family.
What are the subcellular locations of this protein?
Secreted.
Protein: AHK1_ARATH
Sequence: MRGDSFSMSIENLPDSPMGSRKKKMQIRKVFDKMTEWVTPWRSNLESPREMMILRGDVEQDEFQYASSHCLSSYYSVFVVRLAIMVMLAILIGLLTVLTWHFTRIYTKQSLQTLAYGLRYELLQRPVLRMWSVLNTTSELTTAQVKLSEYVIKKYDKPTTQEELVEMYQAMKDVTWALFASAKALNAITINYRNGFVQAFHRDPASSSTFYIFSDLKNYSISGTGPEDVSGWNNKSIHGNMSAIWYQQQLDPVTGENLGKPLKIPPDDLINIAGISQVPDGEASWHVTVSKYMDSPLLSAALPVFDASNKSIVAVVGVTTALYSVGQLMRDLVEVHGGHIYLTSQEGYLLATSTDGPLLKNTSNGPQLMKATDSEEWVIKSGAQWLEKTYGSKRPHVVHAENVKLGDQRYYIDSFYLNLKRLPIVGVVIIPRKFIMGKVDERAFKTLIILISASVCIFFIGCVCILILTNGVSKEMKLRAELIRQLDARRRAEASSNYKSQFLANMSHELRTPMAAVIGLLDILISDDCLSNEQYATVTQIRKCSTALLRLLNNILDLSKVESGKLVLEEAEFDLGRELEGLVDMFSVQCINHNVETVLDLSDDMPALVRGDSARLVQIFANLISNSIKFTTTGHIILRGWCENINSLHDEMSVSVDRRKPWAPMKTKQVQHRNHLQKSCKNANKMVLWFEVDDTGCGIDPSKWDSVFESFEQADPSTTRTHGGTGLGLCIVRNLVNKMGGEIKVVQKNGLGTLMRLYLILSTPDTVDQNIQPDFSKYGLVVMLSMYGSTARMITSKWLRKHGIATVEASDWNELTQIIRDLLETGSRDNSFDSQHNISDPLRAELSNIVEIKNPVFVIVVDIGVLDLTTNIWKEQLNYLDRFSNKAKFAWLLKHDTSNTVKTELRRKGHVMMVNKPLYKAKMIQILEAVIKNRKRGLCNDLRNRGNGSDESHDCLEIDPTQFDTCSSDDSSETSGEKQVDKSVKPSTLHSPVLKNYLIDATTSNDDSTSASMTQKNPEEEDWKDRLYSGIALDGKNQKSLEGIRILLAEDTPVLQRVATIMLEKMGATVTAVWDGQQAVDSLNYKSINAQAPTEEHKSFEEETANKVTTRETSLRNSSPYDLILMDCQMPKMDGYEATKAIRRAEIGTELHIPIVALTAHAMSSDEAKCLEVGMDAYLTKPIDRKLMVSTILSLTKPSAFQTSLSA
What is the function of this protein?
Functions as an osmosensor histidine kinase that detects water stress and transmits the stress signal to a downstream MAPK cascade.  This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain.  Positive regulator of drought and salt stress responses, and abscisic acid (ABA) signaling.  Confers drought tolerance, probably by regulating levels of ABA accumulation.  Plays a redundant role in regulating plant growth and development.  Required for the regulation of desiccation processes during seed formation.
What are the official names of this protein?
Histidine kinase 1, Arabidopsis histidine kinase 1, AtHK1, Protein AUTHENTIC HIS-KINASE 1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.