PharMolix/UniProtQA huggingface dataset:
Protein: PDXA_SYNFM
Sequence: MSSSKPRIALTMGDPCGVGPDVIAQALASPTLFECCTPIVVGDPSALQRSMALSGASKKVLVLREPAELPDDPGSDRIPLIAPVELSGRDIEHGRPTAATCGAVVRYIESAVAFALAGQVRGVCTGPINKARMHEHGFDFPGHTEFLQALTGSRRVVMMLAGPRLRVSLATIHEALADVPALLNVEMLREVIRITAEALIRDFGLQAPRLAVAGLNPHAGEEGRFGREEIEILRPAIESLRPPGRCTVTGPYPADTLFQRAHAGEFDAVVAMYHDQGLVPIKLVHFYDAVNVSLGLPIVRTSVDHGTAYDLAGTGRAHPGSLTAAVQLAALMAHNRFAAVSPVVP
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_LYSSC
Sequence: MGYRKLGRTSSQRKAMLRDLATDLIINERIETTEARAKEVRKAVEKMITLGKRGDLHARRQAAAFIRRELVTTTDAEGNETTSFALQKLFDDVAPRYAERQGGYTRILKVGPRRGDGAPVVVIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: NDKB_PONAB
Sequence: MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYTDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRLMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).  Negatively regulates Rho activity by interacting with AKAP13/LBC.  Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically.  Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter.  Does not bind to duplex NHE III(1).  Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity.  Binds both folded and unfolded G4 with similar low nanomolar affinities.  Stabilizes folded G4s regardless of whether they are prefolded or not.  Exhibits histidine protein kinase activity (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase B, NDK B, NDP kinase B, Histidine protein kinase NDKB.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Nucleus. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.
Protein: GUC2F_HUMAN
Sequence: MFLGLGRFSRLVLWFAAFRKLLGHHGLASAKFLWCLCLLSVMSLPQQVWTLPYKIGVVGPWACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEYVILNEDCQTSRALSSFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDSQSMRKALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQPVEIAAFQRRKAERQLVRNKP
What is the function of this protein?
Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:7777544).  Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity).  May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
What are the official names of this protein?
Retinal guanylyl cyclase 2, RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Photoreceptor outer segment membrane; Single-pass type I membrane protein.
Protein: LCL3_MAGO7
Sequence: MMRWPWSSDSSDGPKPARHWNESLNKTDWEHYKEPRNWVPTAIATTTILAAVQFYRSYLRRIPGTNYIHPGFFRRRSLFGRVTSVGDGDNFHLFHTPGGRLAGWSWLRSIPTERKALKGKTIPVRIAGVDAPEAAHFGREAQPFSAEALEFLKSYILGRDVRTYIYRRDQYERVVGTVWVRRWLLRKDVGLEMIKRGLATVYDAKIGAEFGGLEEKYRAAEAKAKLKKLGMWGAKGKFESPRDYKNRHAATSESKLS
What are the official names of this protein?
Probable endonuclease LCL3.
What is the protein family that this protein belongs to?
Belongs to the LCL3 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single- pass membrane protein.
Protein: PAL4_POPKI
Sequence: STHTLPHSASRAAMLVRINTLLQGYSGIRFEILEAITKLLNHNITPCLPLRGTITASGDLVPLSYIAGLLTGRPNSKAVGPNGETMAAAEAFTLAGINGGFFELQPKEGLALVNGTAVGSGLASMVLFETNVLAILSEVLSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAVMEHILDGSSYVKAAQKLHEIDPLQKPKQDRYALRTSPQWLGPLIEVIRTSTKMIEREINSVNDNPLIDVSRNKALHGGNFPGSPIGVSMDNTLVLAIASIGKLMFAQFSELVNDYYNNGLPSNLTGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISARKTAEAVEILNVMSTTWLVALCQAIDLRHIEENLKNTVKNTVSQVAKRVLTMGFNGELHPSRFCEKDLLKVVDREYVFTYIDDPCSATYPLMQKLRQVLVDHALMNGEKEQNSSTSIFQKIGAFEEELKILLPKEVESARLELENGNPAIPNRITDRRSYPLYKFVREELGTVLLTGEKVGSPGEEFDKVFTAICAGKLIDPCWSVLKEWNGAPLPLC
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase G4.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_LEPIC
Sequence: MAKSHTLNPEEEFEEESGLRPSLLSEFIGQKEVLNNLTVYVQAAKNRKRALDHVLISGPPGLGKTTLAGIISNELGTRLTITSAPVITKGADLARLLTSMGENEILFIDEIHTLPKKLEEILYPAMENYMIDLVIGEGVTAQMVQIPLKPFTLVGATTRSGLISEPLKSRFGIQLRLDYYNDEEMKQIVLRSSKILGVLIEDDAALEIGKRSRKTPRIANHLLKRIRDFSEVEGNLSVKKNLCLKAFEKMGIDDLGLDGMDRQILDCMIDRYKGGPVGLKAIAVVVGEEEKTIEDTYESFMVRIGLINRTPAGRVATEKAYRQLKRMEDFSVHHGQDPTLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YCFP_ECOL6
Sequence: MIIYLHGFDSNSPGNHEKVLQLQFIDPDVRLISYSTRHPKHDMQHLLKEVDKMLQLNVDERPLICGVGLGGYWAERIGFLCDIRQVIFNPNLFPYENMEGKIDRPEEYADIATKCVTNFREKNRDRCLVILSRNDEALNSQRTSEELHHYYEIVWDEEQTHKFKNISPHLQRIKAFKTLG
What are the official names of this protein?
UPF0227 protein YcfP.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: RECA_HERA2
Sequence: MAISPEKEKALAAALSQIDRQFGKGAIMRMSDQRLSIEAIPTGSIALDLALGVGGIPRGRVIEIYGPESSGKTTLTQHIVAETQKMGGVAAFIDAEHAFDPVYAANCGVNVEDLLVSQPDTGEQALEICETLVRSGAIDVIVVDSVAALVPRAEIEGDMGDSHVGLQARLMSQALRKLSGAVSKSRTALIFINQLRMKIGVMFGNPETTTGGNALKFYASVRLDIRKVESIKQGQDVTGARARVKVVKNKVAPPFRQAEFDIMYNEGISREGNIVDVGVTMEILRKSGAWFYLGDDRLGQGRENAKQFLKDNPALADEIEKMIRAASPGAPTAKVIVGAAAANGAAPADDGDGIFDDE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_POPAL
Sequence: MVTIRADEISNIIRERIEQYNREVKIVNTGTVLQVGDGIARIYGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLMIQEGSSVKATGKIAQIPVSEAYLGRVINALAKPIDGRGAISSSESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVNALQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKPSSSLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFASDLDKATQNQLARGQRLRELLKQSQAAPFTVAEQIMTIYTGTNGYLDSLEIGQVRKFLVELRTYLKTSKTQFQEIISSTKTFTEEAEALLKEAIQEQMERFLLQEQV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RS20_ROSDO
Sequence: MANSPQAKKRARQNEARFQINKARRSRIRTFLRRVEEAIASGDKEAATAALRAAQPELMRGVTKGVFHKNTAARKMSRLAARVKVLG
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: U74F1_ARATH
Sequence: MEKMRGHVLAVPFPSQGHITPIRQFCKRLHSKGFKTTHTLTTFIFNTIHLDPSSPISIATISDGYDQGGFSSAGSVPEYLQNFKTFGSKTVADIIRKHQSTDNPITCIVYDSFMPWALDLAMDFGLAAAPFFTQSCAVNYINYLSYINNGSLTLPIKDLPLLELQDLPTFVTPTGSHLAYFEMVLQQFTNFDKADFVLVNSFHDLDLHEEELLSKVCPVLTIGPTVPSMYLDQQIKSDNDYDLNLFDLKEAALCTDWLDKRPEGSVVYIAFGSMAKLSSEQMEEIASAISNFSYLWVVRASEESKLPPGFLETVDKDKSLVLKWSPQLQVLSNKAIGCFMTHCGWNSTMEGLSLGVPMVAMPQWTDQPMNAKYIQDVWKVGVRVKAEKESGICKREEIEFSIKEVMEGEKSKEMKENAGKWRDLAVKSLSEGGSTDININEFVSKIQIK
What is the function of this protein?
Possesses quercetin 7-O-glucosyltransferase and 4'-O-glucosyltransferase activities in vitro.  Also active in vitro on benzoates and benzoate derivatives.  Has low affinity for the tryptophan precursor anthranilate.  Catalyzes the formation of anthranilate glucose ester.  Is a minor source of this activity in the plant.
What are the official names of this protein?
Flavonol 7-O-beta-glucosyltransferase UGT74F1, UDP-glycosyltransferase 74F1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: MTNB_AJECG
Sequence: MAAIKDENNDHLVQSDNPEHPSNLIPALCRNFYSHGWVTGTGGGASIKRDNHIFIAPSGVQKELIQPHDIFVLQYPTPKYPPSARQYIRKPVELKPSACTPLFLAAFDRGAGCCIHTHSQWAVLVTLLVEREKGPEGCFEISNIEQIKGIPRGKGKGMLGFFDTLKIPIIENTAFEEDLTSSLEEAMEKYPDTYAVLVRRHGIYVWGDDVAKAKTQCESLDYLFQLAVEMHKLGLPWVKS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOL4L_PONAB
Sequence: MSDSTWMSADPHLASSLSPSQDERMRSPQNLHSQEDDDSSSESGSGNGSSTLNPSTSSSTQGDPAFPEMNGNGAVAPMDFTTAAEDQPINLCDKLPPATALGTPSYPSDGCGADGLRSRVKYGVKTTPESPPYSSGSYDSIKTEVSGCPEDLTVGRAPTADDDDDDHDDHEDNDKMNDSEGMDPERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAIIESCSRQFPEFQERARKRIRTYHKSCRRMKKNGMEMTRPTPPHLTSAMAENILAAACESETRKAAKRMRLEIYQSSQDEPIALDKQHSRDSAAITHSTYSLPASSYSQDPVYANGGLNYSYRGYGALSSNLQPPASLQTGNHSNGPTDLSMKGGASTTSTTPTPTPSSTSTSRPVPTAQLSPTEISAVRQLIAGYRESAAFLLRSADELENLILQQN
What are the official names of this protein?
Nucleolar protein 4-like.
Protein: SYA_PSYWF
Sequence: MTHSAPSNPTQLPSDKFLRTADVRKAFIDFFVSKQHTHVPSSSLVPYNDPTLLFTNAGMNQFKDCFLGIDKRDYTRAVTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKKSAIAYAWEFLTSKQWLGLDADKLYVTIYESDDEAFDIWHQDIGLAAERIIRIGDNKGAPYASDNFWAMGDTGPCGPCSEVFYDHGEHVEGGLPGTPEEDGDRYIEVWNCVFMQFNRQPDGTMEPLPAPSVDTGMGLERISAILQGVHSNYEIDLFVNLINSAADIIGIKNDNQASLKVVADHIRAVSFLIADGVLPSNEGRGYVLRRIIRRAVRHGNKLGAEDSFFYKMVAPLVKEMGDAYPQLVEKQAFIEKAIEKEEVQFAKTLAQGLRLLDSELESLKSGDVLSGEAAFKLYDTYGFPVDLTADITRERGIGIDEAGFDEQMNIQRQRARDAGKFDVDYSAAIKVETPTEFVGYEQLDEKEVNIIGLYQDGKEVEVLNEGDEGVIVLDRTPFYAEGGGQVGEMGEIRTSSGVFNVEDTKKSGQAFIHHGVVNMGSLQKSQTADAQVVSAIRSASARNHSATHLLHAALRKVLGDSVSQKGSLVSSEMLRFDFSYDNAVSQKDLATIERLVNEQIQANVETHIELMNIDDAMAKGAAALFGEKYGETVRVLTMGTTEIEDGIQKPFSIELCGGLHVKRTGDIGLFKITSESGIAAGIRRIEALTGMGALRYIQQADSQLTALANQLKAKRPEVADRVQTMADKQRELEKQIERLNQKIASAQAATLVDNVQTIADKKVLIAQVAGIDGKAMRGLIDDIKSKLQDTIIILVGEKDGQLALAASVSKSLTGDIKAGDIIRHLADELEGKGGGKPDYAQGGAPSSDKLTGVMQALPNWVASQLS
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF2_VIGUN
Sequence: KTCMTKKEGWGRCLIDTTCAHSCRKYGYMGGKCQGITRRCYCLLNC
What is the function of this protein?
Has antibacterial activity against the Gram-positive bacterium S. aureus and the Gram-negative bacteria E. coli and P. syringae.  Does not have antibacterial activity against the phytopathogenic bacteria R. solanacearum, Rhataybacter sp and Erwinia sp.  Does not inhibit trypsin, chymotrypsin or alpha-amylases.
What are the official names of this protein?
Defensin-like protein 2, Cp-thionin II, Cp-thionin-2, Gamma-thionin II.
What is the protein family that this protein belongs to?
Belongs to the DEFL family. Protease inhibitor I18 (RTI/MTI-2) subfamily.
Protein: ECD_SCHPO
Sequence: MSNLGNNITERIESDCISQNECRIDVYFSEKEKESTEASINMFLAELERLQLEYGKEHIWQNEELNLQRVEYQGKDCILGITNFGDCIDDEWYIVWLLREASKAVKSAFVRIIDEDGEFLLIEAALSLPKWIDEDNSDYRVWIHNGEVIILRPEDEFLKKMNRCPPLTREQAIFQISSGSNLYTSREVNDSISQRLKKFPKAANVKLRAICTVPRKIVHVLQKNKNLISSAVNAFYYRDPIDENYCDRMSKFNQNDLVTTTITFTPLLYAQLYQQRCKTFRPFHLPSDVHSLDYERAILGMKLSCGFEILYNSKENVEKRTEIDEYLQIQPLPTDEDIKKIPLIEDDTSFMNVNPDELEELLEKKLNSFCDDFGDDERSGFDNTDHDNTLVGEEEMVPGNHGGKSINEEITKNKQKQNFNESDLKNMASRIETFINDEASNNHREDFYGVKNSDTDTDSDSLADSDDEIFLNRNQGIDEVEFDETKFYDLLKGKDGKYQNQDVDEFSSGNEDEMDIPGDANMEEYMRAMDEELYGGLRGRDEGLEGIDDKDIDLNLMKNIIEGIEANPDLYGGPISTLLNSLKIQIPREK
What is the function of this protein?
Involved in the regulation of carbohydrate metabolism.  May act as a transcription factor.
What are the official names of this protein?
Protein ecdysoneless homolog, Suppressor of GCR two, sgt1.
What is the protein family that this protein belongs to?
Belongs to the ECD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DUS1_HUMAN
Sequence: MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
What is the function of this protein?
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
What are the official names of this protein?
Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, MAP kinase phosphatase 1, MKP-1, Protein-tyrosine phosphatase CL100.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYP_OENOB
Sequence: MKQSKIFIPTEKEVPAEAQVKSHIFMLRAGFIRQVAGGIYAYLPLANRIINKIESIIREEMNRIDANEMLMPEMIPAELWKESGRFYTYGPQMYQLKDRHDREFIMAPTHEETFTKIISDEIKSYKKLPLILYQIQQKFRDELRPKNGLLRGREFIMKDAYSFSSDQKGLDDAYDLIESAYKRIFDRVGLDYREIIADSGSMGGKDSAEFQAIAATGEDIIAYSNSGKYAANIEMAEEFFEKKIPDEDKKALVLVDTPNAKTVADDADYLHVPTHKIAKCIVFEADDELVAVIIPGDYDVNEIKVKNFLDAKHLSEAEEQEVFKIFGAHFGSLGPVGLKNKDIRILVDRTIQNEANWFVGSNHDGQHYANFNLDRDLKDFETGDFLTAKEGSISPDGKGKLVFTKGIEIGHIFKLGTFYTSKMGGQIQNEKGKLSDIIMGCYGIGISRLLSAIAEQSNDPKGFIWPKAVAPFNVHLITMNTKNESQVNLTKQIDKNLQEAGFEVLVDDRKERPGVKFADSDLIGIPIRVVVGRQADQQIVEVKARGQESTNDVSTDNLIAFLKDKLNELK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_BACAA
Sequence: MENISDLWNSALKELEKKVSKPSYETWLKSTTAHNLKKDVLTITAPNEFARDWLESHYSELISETLYDLTGAKLAIRFIIPQSQAEEEIDLPPAKPNAAQDDSNHLPQSMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIEHNPNAKVVYLSSEKFTNEFINSIRDNKAVDFRNKYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNALHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPNSKPKIISIYDIQKAVGDVYQVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLKTDTQLQKQVEEINDILK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROBW_OLEEU
Sequence: MSWQTYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHFGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVCGIYEEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-4, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PRIA_RICTY
Sequence: MRIAKILLPVSKLFPLDYLITEDLELNIGDLVVVHFRNQELTGIVWELATNSEAKKIKTIKAKVPLNLNISLEVLALIKWMSSYYMSELGSIAKLVLPINIAEKPIKIKEQQVKNYFVLPQLSEEQKQAVTIFNESNKPTLIKGVTGSGKTEIYFHIIADHLMKGQQVLIMLPEIALSRQIINRFIDRFGFEPIIWNSSVTKAQKKMILRGILSDKVKVVIGARSSLFLPFHNLGLIVIDEEHDDSYKQDDNILYNARDTAIVRGVFDKAKIVLCSATPSLETIYNIKTHKYQLVTLVNRYKNIDLPNIEIIDMTKEKLPKNSYLSKILIDAIKGNLENKKQVLLFLNRRGYAPLMLCKACGHRFTCRFCSAWMVLHKATKTLECHHCGYQSKIFSSCPECLEDETLTICGPGIERIEEEAMLLFPKSKIAVISKDHAKTPAKIAQLLHQMENLEIDILIGTQIITKGYHFPNLTLVGVIDADLGSNNAELRASERTFQLLHQVGGRAGRGDSKGVVYLQSYYPDNIIFSYVKVGDEDSFFTNELEIRKAANMPPFSKTASLILSGFSESKILDIAKNIVQIAPKANVKILGPARALMSKLAGKYRYRILIIADKKFNLQQYLKFWLSLIKIPSYCQIKIDIDPKTFY
What is the function of this protein?
Involved in the restart of stalled replication forks.  Recognizes and binds the arrested nascent DNA chain at stalled replication forks.  It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
What are the official names of this protein?
Primosomal protein N', ATP-dependent helicase PriA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. PriA subfamily.
Protein: NAMA_BACCN
Sequence: MNTQLFSPFTIQNVTLKNRIVMSPMCMYSSENEDGKVTNFHLIHYGTRAMGQVGLVMLEATAVAAEGRISNKDLGIWNDEHIEGLQKTVSFIKEHDSKAAIQLAHAGRKAELHTDPVAPSAIPFNDKMKVPVAMSKEQIQDTITAFQKAAIRSKQAGFDVIELHGAHGYLINEFLSPLSNKRTDEYGGTAENRYRFLREIIHAVKEVWEGPLFVRISADDYHPEGLTVNDYVQFAKWMKEQGVDLIDCSSGAVVPAHIDVYPGYQVKYAKHLKEHAQIATGAVGLITSGVQAEQILVNSEADLIFVGRELLRNPYFPRTAANELGFELKDPHQYSRAPGKIANTSK
What is the function of this protein?
Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones.  It also reduces the nitro group of nitroester and nitroaromatic compounds.  It could have a role in detoxification processes.
What are the official names of this protein?
NADPH dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.
Protein: EX7S_RICFE
Sequence: MTNTKTLEENISFEEALKELEEIVKKIDNGQESLETAVNSFERGILLKNHCEKKLKEARLKIEKITKLADSTGVLEETEV
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.