PharMolix/UniProtQA huggingface dataset:
Protein: NCAP_I34A0
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVSGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYRRRDGKWVRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATSPIVPSLDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: YULB_BACSU
Sequence: MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLEKEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDASTTAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSLETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSHIASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YulB.
Protein: GYRB_STRPQ
Sequence: MIEENKHFEKKMQEYDASQIQVLEGLEAVRMRPGMYIGSTAKEGLHHLVWEIVDNSIDEALAGFASHIKVFIEADNSITVVDDGRGIPVDIQVKTGRPAVETVFTVLHAGGKFGGGSYKVSGGLHGVGSSVVNALSTQLDVRVYKNGQIHYQEFKRGAVVADLEVIGTTDVTGTTVHFTPDPEIFTETTQFDYSVLAKRIQELAFLNRGLKISITDKRSGMEQEEHFHYEGGIGSYVEFLNDKKDVIFETPIYTDGELEGIAVEVAMQYTTSYQETVMSFANNIHTHEGGTHEQGFRAALTRVINDYAKKNKILKENEDNLTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFQRFLLENPQVARKIVEKGILASKARIAAKRAREVTRKKSGLEISNLPGKLADCSSNDANQNELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKATMDKILANEEIRSLFTAMGTGFGADFDVSKARYQKLVIMTDADVDGAHIRTLLLTLIYRFMRPVLEAGYVYIAQPPIYGVKVGSEIKEYIQPGIDQEDQLKTALEKYSIGRSKPTVQRYKGLGEMDDHQLWETTMDPENRLMARVTVDDAAEADKVFDMLMGDRVEPRRDFIEENAVYSTLDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRAD4_HUMAN
Sequence: MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV
What is the function of this protein?
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression.  In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor.  Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription.  Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
What are the official names of this protein?
Low-density lipoprotein receptor class A domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the PMEPA1 family.
What are the subcellular locations of this protein?
Early endosome membrane; Single-pass membrane protein.
Protein: COBS_ECO7I
Sequence: MSKLFWAMLSFITRLPVPRRWSQGLDFEHYSRGIITFPLIGLLLGAISGLVFMVLQAWCGVPLAALFSVLVLALMTGGFHLDGLADTCDGVFSARSRDRMLEIMRDSRLGTHGGLALIFVVLAKILVLSELALRGEPILASLAAACAVSRGTAALLMYRHRYAREEGLGNVFIGKIDGRQTCVTLGLAAIFAAVLLPGMHGVAAMVVTMVAIFILGQLLKRTLGGQTGDTLGAAIEFGELVFLLALL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BIOB_PAEAT
Sequence: MPVTSTDTVKDMTTRATQAPRETASYAILETAREQVLERGEGLNESQLIHILELPDDAIPEALQLAHEVRLKHCGEDVEVEGIISIKTGGCPEDCHFCSQSGLFDSPVRGVWLDIPELVKAAKETAATGATEFCIVAAVRGPDIKLMNQIKFAIDRINEEVDINIACSLGMLTQRQVDQLAEWGVHRYNHNLETARSYFPEVVTTHSYEERLETCAMVKAAGMELCCGALIGMGESLAQRAELAAQLAALEPHEVPLNFLNPRPGTPLENQGIMDGKDALRAIAAFRLAMPRTVLRYAGGRELTLGDLGTREGLLGGINAVIVGNYLTTLGRPANADLNLLVELNMPIKEFQKSL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: NQRD_AERS4
Sequence: MADKSEMKKLLLTPVLGNNPIALQVLGVCSALAVTSQMKTAFVMTLAVTAVTAFSNLFISLIRNQIPNSVRIIAQMAVIASLVIVVDQVLKAYAYEISKQLSVFVGLIITNCIVMGRAEAYAMKSAPLPSFLDGIGNGLGYGAVLLTVATVREILGSGTWFGIELLPLVNNGGWYVPNGLLLLPPSAFFIIGLIIWGVRTRDPKQVEAKD
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y2450_CLOBH
Sequence: MEEIVEMSLLLDFYGSLLTEKQNKIMDLYYNNDYSLKEISELTNTSRQAVHDIVKRCHKALLQYEEKLHMMERFINLENSKEKLLNMLNKVTKENIKEIDHIKKYIIDNI
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein CBO2450/CLC_2298.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: MDH_AROAE
Sequence: MSKAPVRVAVTGAAGQIGYSLLFRIASGEMLGKDQPVILQLLDLPQAQKAVKGVMMELEDCAFPLLAGMVATDDPNVAFKDADYCLLVGARPRGPGMERADLLTANGAIFTVQGKAIAENANENVKVLVVGNPCNTNAYIAGAAARKVGRTNPNNYHGMLRLDHNRALSQLAAKTGRPVSSLKKMVVWGNHSPTMYADYRFCTSNGDSVKALVNDHAWNNDVFLPTVGKRGAAIIDARGLSSAASAANAAIDHMHDWALGSDDWVTMGVPSDGSYGIPAGVVFGVPCECKNGDFKIIQGLEIDEYSREKINKTLGELEDERAAVADMLK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: FABPL_ANOPU
Sequence: MAFNGTWQVYSQENYEDFLKAIALPDDIIKAAKDVKPVTEIRQTGNTFVVTSKTPNKSVTNSFTLGKEADMTTMDGKKVKCTVNLVDGKLVAKSDKFIHEQEIVGNEMVETITSGSATFTRRSKKI
What is the function of this protein?
FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
What are the official names of this protein?
Fatty acid-binding protein, liver, Liver basic FABP, LB-FABP, Liver-type fatty acid-binding protein, L-FABP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHI4_CANAL
Sequence: MCHKMMNKFQQRLHHTTSTPLFKTCVYFSNWSVYQKKHFPQDIPIEYYTHIFYAFILIDEQTGKLKFSDEWCDLQMPQPSPNQSITGNLQQFYEMKKKNRHLKLIMSIGGWGTCHLFESVVSNDTKFDNFVNSTIEFAEKYGFDGVDIDWEYPKNSTQAAKLVELLARLRNKLNSKYIITVAAPGGSDNIEILKIQEMDKYLTFWNLMCYDFAGEGWSSKTAFHSNLFGNNGDNSLNASDVVQTYINKGVHPTKLILGMPMYGRIFHGVDRPEIGIPFTKERKSGCIEADVVDYNKFGDTFDYEDFDPRKVGALKYDSHSKQLITFDNLQCARIKASFIQSRQLGGGMWWDSAGDVSVTNDGCLVKNFVDQLGGVEVLEKSANNLHGC
What is the function of this protein?
Chitinase involved in the remodeling of chitin in the fungal cell wall.  Plays a role in sporulation.
What are the official names of this protein?
Chitinase 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ADB4C_MELGA
Sequence: MTPLPAGNGSVPNCSWAAVLSRQWAVGAALSITILVIVAGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLSGHWPYGTVVCELWTSLDVLCVTASIETLCAIAVDRYLAITAPLQYEALVTKGRAWAVVCMVWAISAFISFLPIMNHWWRDGADEQAVRCYDDPRCCDFVTNMTYAIVSSTVSFYVPLLVMIFVYVRVFAVATRHVQLIGKDKVRFLQENPSLSSRGGRWRRPSRLLAIKEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRPLVPDQLFLFLNWLGYVNSAFNPIIYCRSPDFRSAFRKLLCCPRRADRRLHAAPQDPQHCSCAFSPRGDPMEDSKAVDPGHLREDSEVQGSGRREENASSHGGGHQQRPLGECWLQGMQSMLCEQLDEFTSTEMPAGPSV
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.
What are the official names of this protein?
Beta-4C adrenergic receptor, Beta-4C adrenoreceptor, Beta-4C adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB4C sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MIAA_LACJO
Sequence: MQKIIVLIGPTGIGKTDLALDLAPKINAEIISGDSMQIYQEVSIGTAKPTDEELKRVKHYLINQRSIFEEYSVKDFVAEGTKAVDKIVADGAIPLVVGGTGFYINALVNQLQLGEPGEYQTSVDPQWEEYLKENGENKLWDLLQAKDPAAAEKIAPQNSRRSLRALTVISRTGKLFSEQQQKINPRYDALILGLNSDREEVYQRINMRVDKMMEHGLLQEAKFVYENRSREHQVIQAIGYKEFFPYFSGEKTLDECVNKLKQASRKYAKRQLTYFKHQLPVVWLDPLQDEKVSEKALRKINEFLNK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: XKS1_YEAST
Sequence: MLCSVIQRQTREVSNTMSLDSYYLGFDLSTQQLKCLAINQDLKIVHSETVEFEKDLPHYHTKKGVYIHGDTIECPVAMWLEALDLVLSKYREAKFPLNKVMAVSGSCQQHGSVYWSSQAESLLEQLNKKPEKDLLHYVSSVAFARQTAPNWQDHSTAKQCQEFEECIGGPEKMAQLTGSRAHFRFTGPQILKIAQLEPEAYEKTKTISLVSNFLTSILVGHLVELEEADACGMNLYDIRERKFSDELLHLIDSSSKDKTIRQKLMRAPMKNLIAGTICKYFIEKYGFNTNCKVSPMTGDNLATICSLPLRKNDVLVSLGTSTTVLLVTDKYHPSPNYHLFIHPTLPNHYMGMICYCNGSLARERIRDELNKERENNYEKTNDWTLFNQAVLDDSESSENELGVYFPLGEIVPSVKAINKRVIFNPKTGMIEREVAKFKDKRHDAKNIVESQALSCRVRISPLLSDSNASSQQRLNEDTIVKFDYDESPLRDYLNKRPERTFFVGGASKNDAIVKKFAQVIGATKGNFRLETPNSCALGGCYKAMWSLLYDSNKIAVPFDKFLNDNFPWHVMESISDVDNENWDRYNSKIVPLSELEKTLI
What is the function of this protein?
Xylulose kinase necessary for growth in culture media with D-xylulose as the solecarbon source.
What are the official names of this protein?
Xylulose kinase, Xylulokinase.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RL35_ALKOO
Sequence: MPKMKTHRGAAKRFKKTGTGKIKRSKAYTSHILTKKSPKRKRKLRKAGIVFKGDQRRIAQLLPY
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: MOAA_BACCN
Sequence: MHEKVRDSFGRPLQDLRISVIDRCNFRCTYCMPAEVFGPDYAFLQEEFLLTFDEIERLAKLFAGIGVKKIRLTGGEPLLRKDLPKLIKRLASLDGITDIGLTTNGIHLTKQAKALKEAGLQRVNVSLDAIEDNVFQKINGRNVSTKPVLKGIIAAKEVGLEVKVNMVVKKGMNDSQVLPMATCFKEQGIPLRFIEFMDVGSTNGWNFEQVVTKQELIEMIGNVYPIEPAEPHYFGEVAKRYCYIGSDVEVGFITSVSESFCSSCTRARISADGKFYTCLFATEGTDLRALLRTNCSDNELLQVIQDVWRYRKDRYSDERTEESAKNRAKIEMSYIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: MIAB_MYCPA
Sequence: MTCGFSRADRSPYHGPVTSTVARDVSGVRTYQVRTYGCQMNVHDSERLAGLLEAAGYRRAAEGAEVADVVVFNTCAVRENADNKLYGNLSHLAPRKRGNPEMQIAVGGCLAQKDREAVLRRAPWVDVVFGTHNIGSLPTLLERARHNKAAQVEIAEALQQFPSSLPSARESAYAAWVSISVGCNNSCTFCIVPSLRGKEVDRSPDDILAEVRSLVADGVLEVTLLGQNVNAYGVSFADPALPRDRGAFARLLRACGEIDGLERVRFTSPHPAEFTDDVIEAMAQTPNVCPALHMPLQSGSDRVLRAMRRSYRAERFLGIIDRVRAAMPHAAITTDLIVGFPGETEEDFAATLDVVRRARFAAAFTFQYSKRPGTPAAELDGQIPKAVVQERYERLVELQESISLQGNQALVGQTVELLVATGEGRKDSATARMSGRARDGRLVHFAADDRVRPGDLVTTVITGAAPHHLIADAGVLSHRRTRAGDAHAAGRRPRGVGLGMPAVGPPAGPAQPVGCAS
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y417_METJA
Sequence: MKVDLHVHSIVSKCSLNPKGLLEKFCIKKNIVPAICDHNKLTKLNFAIPGEEIATNSGEFIGLFLTEEIPANLDLYEALDRVREQGALIYLPHPFDLNRRRSLAKFNVLEEREFLKYVHVVEVFNSRCRSIEPNLKALEYAEKYDFAMAFGSDAHFIWEVGNAYIKFSELNIEKPDDLSPKEFLNLLKIKTDELLKAKSNLLKNPWKTRWHYGKLGSKYNIALYSKVVKNVRRKLNI
What are the official names of this protein?
Uncharacterized protein MJ0417.
Protein: SL9A6_MOUSE
Sequence: MAGARRGWRLAPVRRGVCGPRARPLMRPLWLLFAVSFFGWTGALDGSGGTTRAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPDNERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTESATASAPRRFMGNSSEDALDRELTFGDHELVIRGTRLVLPMDDSEPALNSLDDTRHSPA
What is the function of this protein?
Endosomal Na(+), K(+)/H(+) antiporter.  Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+).  By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification.  Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e. g. , endosome maturation and trafficking of recycling endosomal cargo (PubMed:17005858, PubMed:21413028, PubMed:24035762, PubMed:34526390).  Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (PubMed:21413028, PubMed:34526390).  Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (By similarity).  Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (PubMed:17005858, PubMed:21413028).
What are the official names of this protein?
Sodium/hydrogen exchanger 6, Na(+)/H(+) exchanger 6, NHE-6, Sodium/hydrogen exchanger, Solute carrier family 9 member 6.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein: PSBN_LOTJA
Sequence: METATLVAISISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: T4BB_WEICA
Sequence: MNNLIKYSTFLISDLFDVVIGKTIDGNKAQRNENGTPYITRKATRNGFEFMIDGEKEKLYSGKLPVITIGNETSKPFVQEFHFFTGTKVNICIPKLDLNRNHLLYITTMIENATKMFSYSYTINSTRLKSLKILLPIKGEEPDWDYMNTYISKILSNMEKNFDVQQNDGVSDLRSLKDLSWSQFKMDEIFSINSGVRLTKADMKPGNIPFIGATDSNNGITEFTSSTNASFDGNVLGVNYNGSVVENFYHPYKAVFSDDVKRLKLKNYPNNKHVLLFMKVVILQQKVKYAYGYKFNATRMKEQIILLPTKADGTPDYEFMEQYMMRMENKVVGRTTEKEAD
What is the function of this protein?
The specificity subunit (PubMed:12654995).  A B, G, H and S subtype restriction enzyme that recognizes the double-stranded sequence 5'-CGAN(6)TGC-3' and cleaves bilaterally and symmetrically 10 base pairs upstream and 12 base pairs downstream of the sequence to release a 34-base pair fragment.  Methylation of the recognition sequence occurs on the adenine in either one or both strands; seems to methylate restricted DNA (PubMed:8451198, PubMed:8276869, PubMed:12654995).  This subunit degrades DNA in a non-specific manner (PubMed:8276869).
What are the official names of this protein?
Type II restriction enzyme BgcI specificity subunit S.BcgI, S.BcgI, Restriction enzyme BgcI subunit B.
What is the protein family that this protein belongs to?
Belongs to the type-I restriction system S methylase family.
Protein: HTPG_GEOUR
Sequence: MTKSTKKFETEVQQLLDLVIHSLYSNKDIFLRELVSNASDAIDKVKFESHSNMDILEGNTDWKIKLIPDKTAGTLTIRDNGIGMNVVEVEENIGTIARSGTRAFMENLKDKNVQNNPELIGQFGVGFYASFMVADKVTLITRKAGDKNAACRWESTGDGSYTIEDCEKETRGTDITLHLKDEMKEYLDEWKIRSIIKKYSDYVQYPVVMDVTRDEPAKGVDGEVIEGGGTIEKTTEETLNSMKAIWTRAKSEISEEEYEEFYKHISHDYDKPFRTIHYSAEGTSEFKALIYIPSHKPFDLFMRDHKKGVHLYVKRVFITDNCEALLPDYLRFMKGVVDSSDLPLNVSREILQEDIQIKRIEKNLVGKILSTLVETKEKTPEDYLKFYKEFGPVLKEGVHFDHANKEKLQELILFESSKTEAGNYISLKEYVARMPEAQKEIYYITGASRSALENSPHLEIFRKKGFEVLYMTDPVDEWVVQSLTDYDGKKLHAVDRGDLELDSAEEKKEKEAKQEEAKKQYQGVLDFVKEQLKDKVKEVRFSSRLTDSACCLVADEYGLNANMEKILKAMNQDVPESKRVLELNPDHPLMQVLSSIFEKDKENPRLADYCGLLYDQALLTEGSPVPDPLRFTRLVAELMVKAAEK
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_PROM2
Sequence: MAKKGTRVVVTLECTEARTSTDPKRSNGVSRYTTEKNRRNTTERLELKKFNPHLNRMTIHKEIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: CYB_CTEAU
Sequence: MTNTRKSHPLIKIVNHSFIDLPAPSNISAWWNFGSLLGVCLGLQILTGLFLAMHYTADTTTAFSSVTHICRDVNYGWLIRYMHANGASMFFIFLYFHIGRGIYYGSYTFMNTWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGPTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAMVMIHLLFLHETGSNNPSGMNSDSDKIPFHPYYTIKDILGILFMMITLMSLVMFTPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILMLFPILHSSKQRSMSFRPLSQCLMWMLVANLLILTWIGGQPVEHPFITIGQLASVTYFFIILILMPSTALMENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL18_ACAM1
Sequence: MKTTRRDATRSRHQRVRRKVVGTAERPRLAVFRSNQHIYAQVIDDAQQHTLAAASTVESDLKSSSGATCDASTAVGKLVAERAIEKGIKAVVFDRGGNLYHGRVKALADAAREAGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: MT1A_MORBO
Sequence: MKPFIKWAGGKNSLLDEIQKRLPDFVHSQDFCLVEPFVGGGAVSLWALSDLPHLKQLVINDCNADLINVYQVIKNNPDDLIGYIENLQSHYDKLTDLESKKPYFYHKRDVFNQRTSNDIEQAGLFIFLNKSAFNGLYRVNKNNQFNVPIGNYKKPTFVDKENILNISKKLQNTKILSGDFELVLAHLPNNFPCLFYLDPPYRPISDTASFTSYSDNGFDDNEQKRLANFCKKIDKLGHYFLLSNSDPKNTNSSDEFFDELYQDFKIERIQANRTISANSNGRKKVNEIIVSNGV
What is the function of this protein?
An alpha subtype methylase that recognizes the double-stranded sequence 5'-GATC-3', methylates A-2 on both strands, and protects the DNA from cleavage by the MboI endonuclease (PubMed:12654995) (Probable).  This seems to be a stronger methylase than M2. MboI (Probable).
What are the official names of this protein?
Type II methyltransferase M1.MboI, M1.MboI, Adenine-specific methyltransferase MboIA, M.MboA, Modification methylase MboIA, M.MboIA.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: Y1012_STAA3
Sequence: MAKQATMKNAALKQLTKDADEILHLIKVQLDNLTLPSCPLYEEVLDTQMFGLQKEVDFAVKLGLVDREDGKQIMLRLEKELSKLHEAFTLV
What are the official names of this protein?
UPF0358 protein SAUSA300_1012.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.
Protein: BFPA_ECO27
Sequence: MVSKIMNKKYEKGLSLIESAMVLALAATVTAGVMFYYQSASDSNKSQNAISEVMSATSAINGLYIGQTSYSGLDSTILLNTSAIPDNYKDTTNKKITNPFGGELNVGPANNNTAFGYYLTLTRLDKAACVSLATLNLGTSAKGYGVNISGENNITSFGNSADQAAKSTAITPAEAATACKNTDSTNKVTYFMK
What is the function of this protein?
Major component of type IV bundle-forming pili (BFP) that plays a role in adherence to host cells and virulence.
What are the official names of this protein?
Major structural subunit of bundle-forming pilus, Bundle-forming pilin, BFP, Bundlin.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.