PharMolix/UniProtQA huggingface dataset:
Protein: EGL1_CAEEL
Sequence: MLMLTFASTSSDLLPMSNVFDVQSSVFYNEKNMFYSSSQDFSSCEDSSQFADDSGFFDDSEISSIGYEIGSKLAAMCDDFDAQMMSYSAHASDRSLFHRLLDFFAF
What is the function of this protein?
Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9 (PubMed:9604928, PubMed:10688797, PubMed:15383288).  Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 (PubMed:9604928, PubMed:10688797, PubMed:15383288).  Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis (PubMed:12874127).  Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron during embryogenesis (PubMed:20713707).  During larval development, required for the elimination of transient presynaptic components upstream of ced-9, ced-4 and ced-3 apoptotic pathway (PubMed:26074078).  Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3 and ced-4, regulates temporal cell fate patterning during larval development (PubMed:25432023).  Has been shown in two studies to be dispensable in mitochondrial dynamics and morphology during early embryonic development (PubMed:19327994, PubMed:21949250).  However, one study shows that during larval development, egl-1 is involved in modulating mitochondrial dynamics, perhaps acting by stabilizing the interaction between ced-9 and drp-1 in order to promote mitochondrial fission (PubMed:21949250).  Involved in inducing mitochondrial fragmentation during apoptosis, probably acting via ced-9 and dynamin-related protein drp-1 (PubMed:15716954).
What are the official names of this protein?
Programmed cell death activator egl-1, Egg-laying defective protein 1.
What are the subcellular locations of this protein?
Synapse. Note=Localizes to RMED/V synaptic regions in L1 larvae.
Protein: TIM23_RAT
Sequence: MEGGGGSSNKSTGGLAGFFGAGGAGYSNADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGALNGLRLGLKETQSMPWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDFNTVAAGTMTGMLYKCTGGLRGIARGGLAGLTLTSVYALYNNWEHMKGSLLQQSL
What is the function of this protein?
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim23.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RECO_COXBR
Sequence: MTKRVALEPAFILHRRPYSNTSLILELLTPNHGRVCALARSARGLKSRYKGKLELFSPLLISWSGRSDLKFLGDVEANGMPYLLEGEALLCGFYLNELLIRLLHHDDPYLRLFHHYQNTLEKLVNGRLEATLRCFEKQLLDELGYGLPLSCDVEMKLPFKPDQFYQYLPDRGFLLCEKSEESEERDVFSGKSLLALQEESFSDESSLKEIKYLMRLTLNRLLGKKPLKTRELLF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RL2_METRJ
Sequence: MALKTFKPVTPSLRQLVLVDRRELYKGKPVKALTEGKSSSGGRNNLGRITVRFRGGGHKRVLRNVDFKRRDQLGVAATVERIEYDPNRTAFIALINFPDGKQSYILAPQRLQPGDKVVAGESVDIKPGNAGPVGSMPVGTIVHNVELKIGKGGAIARSAGNYAQIVGRDQGYVTLRLNSGEQRLVHGQCFASVGAVSNPDHMNISLGKAGRNRWLGKRPHNRGVAMNPVDHPHGGGEGRTSGGRNPVTPWGVPTKGKKTRSNKRTDVFILSSRHNRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SYDND_ORITB
Sequence: MHKYRTHTCGELSLAHVGLQVKLSGWLYRRRDHGGLLFIDLRDHYGIIQLVFNDDCSAVQAEISKIKFETVITVEGAVVARSNETINKNISTGDVEVVVSSYVVESFAEELPLQINGEYEAPEETRLKYRFLDLRGARLHQNIVLRSKVIQELRNQMLSNGFIEFQTPILTASSPEGARDFLVPSRLHPGKFYALPQAPQQFKQLIMMSGFDKYFQIAPCFRDEDARADRSPGEFYQLDIEMAFVTQEDVFGLVEPVLYNTFKKFSNYSITNIPFPRITYDESMLRYGSDKPDLRNPIQISDVTDIFQCSEFTTLKDSINCGAVVRAIPAPMSANKPRSFFDKMIEYAKHLGASGLAYIQFTNDGVKGSIAKFFDEALLARIKKLVKCQDGDAIFFICDKENDATKVAAKIRAKVGEELNIIKTDCYKFCWVIDFPFYQLDSEINKITFSHNPFSMPQGGIEAFNKAKTVEDLLSIKAFQYDIVCNGVELSSGAIRNHKPDLMYKAFAIVGYSKDEVDKQFGAMIRAFCYGAPPHGGIAPGIDRILMLLTNSVNIREVIAFPMNQQAEDLLMGCPAAVTDKQLHELQLKLISKERIK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPR38_ARATH
Sequence: MMIKRSITTNMKALRLIQPHLLKTGSLRTDLLCTISSFFSSCERDFSSISNGNVCFRERLRSGIVDIKKDDAIALFQEMIRSRPLPSLVDFSRFFSAIARTKQFNLVLDFCKQLELNGIAHNIYTLNIMINCFCRCCKTCFAYSVLGKVMKLGYEPDTTTFNTLIKGLFLEGKVSEAVVLVDRMVENGCQPDVVTYNSIVNGICRSGDTSLALDLLRKMEERNVKADVFTYSTIIDSLCRDGCIDAAISLFKEMETKGIKSSVVTYNSLVRGLCKAGKWNDGALLLKDMVSREIVPNVITFNVLLDVFVKEGKLQEANELYKEMITRGISPNIITYNTLMDGYCMQNRLSEANNMLDLMVRNKCSPDIVTFTSLIKGYCMVKRVDDGMKVFRNISKRGLVANAVTYSILVQGFCQSGKIKLAEELFQEMVSHGVLPDVMTYGILLDGLCDNGKLEKALEIFEDLQKSKMDLGIVMYTTIIEGMCKGGKVEDAWNLFCSLPCKGVKPNVMTYTVMISGLCKKGSLSEANILLRKMEEDGNAPNDCTYNTLIRAHLRDGDLTASAKLIEEMKSCGFSADASSIKMVIDMLLSGELDKSFLDMLS
What are the official names of this protein?
Putative pentatricopeptide repeat-containing protein At1g12700, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TTTP_BPT4
Sequence: MSQALQQIFNQANTTNFVVSIPHSNTTSAFTLNAQSVPIPGIRIPVTDTVTGPFGLGRAQRPGVTFEYDPLIVRFIVDEELKSWIGMYEWMLGTSNYLTGENTAQKTGPEYITLYILDNSKTEIVMSINFYKPWVSDLSEVEFSYTEDSDPALVCTATIPYTYFQVEKDGKIIAEV
What is the function of this protein?
Plays an essential role in tail assembly by capping the rapidly polymerizing tail once it has reached its requisite length and serving as the interaction surface for the completion protein.
What are the official names of this protein?
Tail tube terminator protein, TrP, Gene product 3, gp3, Tail sheath-stabilizing protein, Tail-to-head joining protein, THJP.
What are the subcellular locations of this protein?
Virion.
Protein: DNAK_CITBB
Sequence: MSRVIGIDLGTTNSCVAVMEGGEPVVIANAEGSRTTPSMIAFAESGERLVGQQAKRQAVTNPENTLYAIKRLIGRKFETEAVKKDIAISPFKIVKADNSDAWVEVRGQKYSPPEISAMVLQKMKKTAEDYLGEAVTDAVITVPAYFDDSQRQATKDAGKIAGLNVLRIINEPTAAALAYGLDKKKDEKIAVFDLGGGTFDVSILELGEGVFEVKSTNGDTFLGGEDFDQKIIDHIADEFKKDQGIDLRGDKMALQRLKEAGEKAKCELSTSLETDINLPFITADASGPKHLTMKLTRAKLESICAELIAKLEGPCRTALKDAGLSASDIDEVILVGGMTRMPIVQKKVQDIFGKLPNRGVNPDEVVAIGAAIQGGVLRGDVKDVLLLDVTPLSLGIETLGGVLTKLIDKNSTIPCRKSQVFSTAADNQPAVSIHVLQGEREMAADNKTLGNFELSGIPAAPRGVPQIEVTFDIDANGIVHVSAKDLGTGKEQSIRITASSGLSKEEVEKMVREAEAHAADDKKKRELIEAKNQADNLIYQTEKSLTEFGDKIDASEKQKIEEGVAALKKALEGSDADEIKKASDSLMQASHKLAEAVYAKTQGAGAEGGEQPHGEQEAGGAAKGEKVVDADFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: Y066_BORBU
Sequence: MRFIIAFLMILNQGFSNLFSLPPEDIIFESSYEVAIKKAQKLNKNVLILVGRDIKENLIKDFLNSFTNGEIIHKVSRKSVFLVIDKDNEIFNKINLQKSPTIFFVDSKNEQIKAAYVGAVLSSVQFDKDFLNYVMGAIKSTSVLKKQKDYEINTADERTFFYKTLKGDWRLKFNGKDRKLVLFDTDLKEFLVFKDINENKLYAIPKSRIGNIYFSLLGNEEWKLFGKIK
What are the official names of this protein?
Uncharacterized protein BB_0066.
Protein: RRF_PSEPW
Sequence: MINDIKKDAQDRMGKSIEALGRNLASIRTGRAHPSILDSVKVPAWGSEMPLNQVAAVSVEDARTLKIVAHDKNLSAAIEKAILTSDLGLNPSSAGTTIRVPMPALTEETRKGYTKQASAVAEDAKVAVRNVRRDALADLKKLTKDKEISEDEERRAADEIQKLTDKFVAEIDAAFKAKEKDLLAV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPYR_EMENI
Sequence: MSYTVRKIGQPYTLEHRVYIEKDGQPVSPFHDIPLYANAEKTVLNMIVEIPRWTNAKQEISKEEFLNPIKQDTKKGKLRFVRNCFPHKGYLWNYGAFPQTWEDPNVVHPETKAKGDNDPLDVCEIGELVGYPGQVKQVKVLGVMALLDEEETDWKVIVIDVNDPLAPKLNDIEDVERHLPGLLRATNEWFRIYKIPDGKPENQFAFSGEAKNKKYAEEVIHECADAWEKLVSGKSDRGDISLANSTLGNSDSVDSSKLASIPRGENLPPAPIDGTIDKWFFISGAAV
What is the function of this protein?
Involved in osmoadaptation.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_STAEQ
Sequence: MKLHELKAAEGSRRVRNRVGRGAATGNGKTSGRGQKGQKARSGGKLRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESGVVKNEKSGIKVLGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RIMM_SACD2
Sequence: MFTPVEAKKSNLITVGRITGVFGIKGWVKLKSFTDPQDNVLEYSPLLLKTKHGVKECEIAEYQFRPQGLVVRLKGVDDRNAAEALAPVDVAIDKSLLPELDDDDFYWHQLEGLRVVTIYEGNTQDLGVVSKVMATGANDVLEVKPDAQSIDDRDRLVPYVLDLYVKKVDLSAECITVDWDPEF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_ENTFA
Sequence: MGKKRIYELAKEMNKASKDVVDKAHQLGMDVKNHMGAISSEQETKLRQAFGGGSTVNTQSKATNNQKQQTTQNKPANKKPMNNKPGEQRNNQNRPNNQSTNGQQRNNNNQNRHGQSNTQNRSNQTNTNNQNRNTQNNNGSTTNQNRTSQNNNGGNNQNRGGQNRNNNFGGGQNRNNRNNFNNQNRNRFNKKGKKGKHQQESAKPAVPARKFRELPDVLEYTEGMNVADIAKKIHREPAEIIKKLFMMGVMVNQNQALDKDTIELLAVDYGMEPQEKVQVDIADIDKFFEPEAVVEENLTTRPPVVTIMGHVDHGKTTLLDTLRHSRVTSGEAGGITQHIGAYQLDIDGKPITFLDTPGHAAFTSMRARGASITDITILVVAADDGVMPQTIEAINHAKAAKVPIIVAVNKIDKPGANPDHVKQELSEHELIPEEWGGDTIFVNISAKFNQNIDELLENILLIAEVEDLKADPTQKAIGTVIEARLDKGKGPVATLLVQQGTLHVGDPIVVGNTYGRVRVMTNDMGRRDKEAGPATPVEITGLNDVPQAGDRFVVFEDEKTARQAGEERAKRALLEQRSASSRVTLDNLFESLKEGELKEVNIIVKADVQGSAEAVSASLQKIDVEGVRVKIVHAAVGAINESDVTLAAASNAIIIGFNVRPTPQAKQQAEQEEVDIRLHRIIYKALEEIETAMKGLLDPEFEEKITGQMTVRELYKVSKVGTIAGCYVTEGFIRRDSGVRVIRDGIVIYEGKLASLKRFKDDVKEVKLGFECGAMIENFNDLRVDDAIEGFIMEEIKQ
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAB_SALTI
Sequence: MEISWGRAMWRNFLGQSPDWYKLALLVFLIVNPFIFLANPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMTSAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLVCGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKIKLIVQAVIGVWLVTALALHLAEVGLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLSSISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTLIGLLCVEFTLAPATEWMTQAGWLATLS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EMIL3_HUMAN
Sequence: MGRRRLLVWLCAVAALLSGAQARGTPLLARPAPPGASRYSLYTTGWRPRLRPGPHKALCAYVVHRNVTCILQEGAESYVKAEYRQCRWGPKCPGTVTYRTVLRPKYKVGYKTVTDLAWRCCPGFTGKRCPEHLTDHGAASPQLEPEPQIPSGQLDPGPRPPSYSRAAPSPHGRKGPGLFGERLERLEGDVQRLAQTYGTLSGLVASHEDPNRMTGGPRAPAVPVGFGVIPEGLVGPGDRARGPLTPPLDEILSKVTEVSNTLQTKVQLLDKVHGLALGHEAHLQRLREAPPSPLTSLALLEEYVDRRLHRLWGSLLDGFEQKLQGVQSECDLRVQEVRRQCEEGQAASRRLHQSLDGRELALRQELSQLGSQLQGLSVSGRGSCCGQLALINARMDGLERALQAVTETQRGPGAPAGDELTRLSAAMLEGGVDGLLEGLETLNGTEGGARGCCLRLDMGGWGVGGFGTMLEERVQSLEERLATLAGELSHDSASPGRSARPLVQTELAVLEQRLVSLETSCTPSTTSAILDSLVAEVKAWQSRSEALLRQVASHAALLQQLNGTVAEVQGQLAEGTGSSLQGEITLLKVNLNSVSKSLTGLSDSVSQYSDAFLAANTSLDERERKVEAEVQAIQEQVSSQGSRLQAGHRQVLNLRGELEQLKAGVAKVASGLSRCQDTAQKLQHTVGHFDQRVAQVEGACRRLGLLAAGLDSLPTEPLRPREGLWSHVDQLNRTLAQHTQDIARLRDDLLDCQAQLAEQVRPGQAN
What are the official names of this protein?
EMILIN-3, EMILIN-5, Elastin microfibril interface-located protein 3, Elastin microfibril interfacer 3, Elastin microfibril interface-located protein 5, Elastin microfibril interfacer 5.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: EFTU_PSEPF
Sequence: MAKEKFDRSLPHVNVGTIGHVDHGKTTLTAALTRVCSEVFGSAVVEFDKIDSAPEEKARGITINTAHVEYNSNIRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKADLVDDAELLELVEMEVRDLLSTYDFPGDDTPIIIGSARMALEGKDDNEMGTTAVKKLVETLDSYIPEPERAIDKPFLMPIEDVFSISGRGTVVTGRIERGIVRVQDALEIVGLRDTTTTTCTGVEMFRKLLDEGRAGENCGVLLRGTKRDDVERGQVLVKPGSVKPHTKFTAEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGNCELPEGVEMVMPGDNIQMTVTLIKTIAMEDGLRFAIREGGRTVGAGVVAKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_MYCBT
Sequence: MARRPRPDGPQHLLALVRSAVPPVHPAGRPFIAAGLAIAAVGHRYRWLRGTGLLAAAACAGFFRHPQRVPPTRPAAIVAPADGVICAIDSAAPPAELSMGDTPLPRVSIFLSILDAHVQRAPVSGEVIAVQHRPGRFGSADLPEASDDNERTSVRIRMPNGAEVVAVQIAGLVARRIVCDAHVGDKLAIGDTYGLIRFGSRLDTYLPAGAEPIVNVGQRAVAGETVLAECR
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRHO_BACC3
Sequence: MATTKPYRVLLYYMYTTIENPEEFAAEHLAFCNSLELKGRILVAKEGINGTCSGTVEQTEKYMEAMNNDPRFDGIVFKIDEADGHAFKKMHVRPRPELVTLRLEDDINPHEITGKYLEPKDFYEAMKQEDTVIIDARNDYEFDLGHFKGAIKPDIESFRELPDWIRENKEVLEGKKILTYCTGGIRCEKFSGWLVREGYEDVSQLHGGIVTYGKDPEVQGELWDGQCYVFDERIAVPVNQKEHVIVGKDHFTGEPCERYVNCANPECNKKILCSEENEAKYLRACSHECRVSPRNRYVIQHELTEEQVAAALEKIEAGK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: CSRA_BREBN
Sequence: MLVLSRKKNESIMIGDTIEIKIISIDGDQIKLGIDAPRNLDVYRKEIFDAIQEENRLAMKSQSDWASMKQLFQTSKEKRDDQ
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSD_COTGR
Sequence: YLVNPAAYAAPGAYMFLLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAIERWIVVCKPISNFRFTEDHAIMGLAFSWVMALTCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFIVHFLIPLSNNFFCYGRLLCAVKEAAAAQQESETTQRAEREVSRMVVMMVVSFLMCWLPYASVAWYIFCNQGSEFGPIFMTLPAFFAKSSAIYNPLIYICMNKHVRHCMI
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: E2F7_MOUSE
Sequence: MEVNCLTLKDLISPRQTRLDFAIEDAENAQKENIFVDRSRMTPKTPMKNEPIDLSKQRIFTPDRNPITPVKPVDRQPQVEPWTPTANLKMLISAASPDIRDREKKKELFRPIENKEDAFVNSLQLDVAGDGAVDEYEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRTLQRLGEEQKYEEQMACLQQKELDLMGYRFGERRKDGSPDPRDPHLLDFSEADYPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDTPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSIDEELLDVSASILPELKKEAYGQIRVCAKERLVRYGSFNTVHTSEKIQRKVSSEPSSPQGERQGSAYSLEIGSLAAIYRQKVEDNSQEEAFVSNTAVPPASILDPALSMDSEYCVKPLAQPVFSVAQTDLPAFSAQNGPSGQVGVPVPSAASDTENLKPALLAGQPLVYVPSTQLFMLYGSVQEGLSPESRSEEDGGGSDVPADLSVTPSAQKRLCEERDPQEEEDEPAMKRQSQEFEDSPLSLVMPKKPSSSTDLACPVTMGNGSSPPLEDACVKGQLPAAEEVTGKAAPNCYVASECGNPARNPDTEKPSNENEITKDPSLMQYLYVQSPAGLNGFNMVLPGTQTPHTVAPSPAQLPSFGVPCMFLQSPGLGPFPVLYSPAIPGPISSAPGTHPNPGPMNFGLSTLASASHLLISPAAMVNPKPSTLPCTDPQLRCQPSLNLNPVMPGSHGVIHPESPCYVRHPVSMVKAEQSPAPATPKSIQRRHRETFFKTPGSLGDPVFRRKERNQSRNTSSAQRRLEISSSGPD
What is the function of this protein?
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response.  Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'.  Directly represses transcription of classical E2F transcription factors such as E2F1.  Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes.  Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3).  Required for placental development by promoting polyploidization of trophoblast giant cells.  Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication.  Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.  Acts as a negative regulator of keratinocyte differentiation.
What are the official names of this protein?
Transcription factor E2F7, E2F-7.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PEBB_PROM4
Sequence: MKRERNNSLDPLEISEWRWSEFLDDAIKALELFDIEPYPIPEEFLTKEETIKFKNNQIKVKALTWACRTTKIRQARAACIEAGPAASVLNLVINPFHNFELPFFGADFVTLPSGHLLALDLQPVLKKDEIHNQKVWSKLIPIHDHWQSLLPSGGPIPQEAETFFSPGFLWTRLPLDDQGSKLISKVIRPAFQEYLTLYIDLISDAQEVSKERSLEILSGQKAYINYRAEKDPARGMLARFFGKDWTEQYIHKVLFDL
What is the function of this protein?
Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin.
What are the official names of this protein?
Phycoerythrobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: XB31_ORYSJ
Sequence: MGHGLSCSRDTDEYDLFRAAQLGDIHALSALLAADPALARRATVYDRFTALHIAAANGRLQVLSMLLDRDGDVDVLSRKKQTPLMVAAMRGNTECVVRLLRGGANVLTFDSPRARTCLHHAAYYGHAECLQAILGAAAQAQGPVAASWGFARFVNVRDERGATPLHLAARHARASCVRLLLDKGAIVSAPTAVYGFPGSTALHLAARAGSMECIRELLAWGADRLQRDSAGRIAYAVAMRRGHRACAALLNPAAAEPIVWPSPLKFIGELEADAKALLEAALMEANREREKRILHGSDINIKGGDEEEESEDEEEACNICFEQACSMEVKECGHQMCAACTLAICCHSKPNPKTLLLHPPACPFCRTTISRLVVATTNSNKTNSRRRSRSRSSSFKGGLSSAMGSFSRIGRGSGRLVVDGSSVGELADKPDHDFSSVAAAAAICDT
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase XBOS31, Ankyrin repeat domain and RING finger-containing protein XBOS31, RING-type E3 ubiquitin transferase XBOS31, XB3 protein homolog 1.