PharMolix/UniProtQA huggingface dataset:
Protein: RSMH_NATTJ
Sequence: MNFNHEPVMIEKTIELLKPESAQVIVDGTMGGAGHSLRIINSLPPEGILVGIDQDPDAYEAGKSLLEAYGNKAKVFNDNFVNIKHICERIGIHYVDGILLDLGVSSYQLDNKDRGFTYQENAPLDMRMDKSQKITASEVVNTYSEQKLAEIIREYGEEKWAQRIAQFIVQARQDQEINTTQELVKVIKAAIPKGARKSGPHPAKRTFQALRIHVNGELDSLRTAIQEGIRLLRGKGRFVVITFHSLEDRIVKQEFKKLAQTCVCPTKLPICQCKGEATVKLLTKKPLLPSQGEIEINPRARSAKLRAVERLGSNN
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRRX1_HUMAN
Sequence: MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADENVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN
What is the function of this protein?
Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types.  The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).
What are the official names of this protein?
Paired mesoderm homeobox protein 1, Homeobox protein PHOX1, Paired-related homeobox protein 1, PRX-1.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECO_PELPD
Sequence: MHPEKLQAYVLSTLDYGDSDRIVALFTLEHGRIKAFARRARNSRRRFGAALEIFARIEAHVEIKQGGLSGLRQAEIDCIYPGIRGDLGRIAYALYACELVDAMTPEGHPLPRLFRLLAAYLDRLEAYPASEQERRFFEINLLNILGYRPSLEACSRCGTPFDDRGALLLDDGELVCRACTGHGRDMTQVTLGRMLACLKTGTFGLIHFPDEAQAQTGSALDRALAFHAGHRLKSLEFLRQISNENQ
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RS2_SHEB9
Sequence: MTTVSMRDMLQAGVHFGHQTRYWNPKMKPFIFGARNGVHIINLEHTVPMFNEALAFISNVASKKGKVLFVGTKRAAGEAIKESALSCDQFYVDHRWLGGMLTNWKTVRQSIKRLKELESQSVDGTFDKLTKKEALMRTRELEKLEKSLGGIKNMGGLPDVLFVIGADHEHIAIKEANNLGIPVVAVVDTNSAPDGVNYIVPGNDDAMRAIRLYTSSVAAAAKAGRGQDLAVQAEQDGFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: LEPA_MALP2
Sequence: MDKKYIRNFSIVAHIDHGKSTLSDRIIEFTNTLTTREMKNQILDSMDIERERGITIKLNAVQLIYHNPKDNQDYYFHLIDTPGHVDFTYEVSRSLAACEGALLVVDASQGVEAQTLSNVYLALENNLEIVPVINKIDLPSADIDRVKKQVEDTIGLDCSNAPLVSAKTGLNINQIMEAIIEQIPPPLDSDDNKPLQALVFDSYYDAYKGAVCLVRIKNGQVKVGTKIRFMSNNETFIVSALGVNTPKIVNKEVLVAGEVGWIAASIKNIKSISVGDTITDDANPATTSLPGYKKILPMVYCGLYPIDSTQYELFKEALEKIYLSDSSLTYEYETSQALGFGIRCGFLGLLHMDVIRERLDREFNIALIATAPSVIYKVLLNDGTILEIDSAAKLPDKTLYKEIQEPFAKAEIIVPDDFLGNVMELCQNYRGEYLDLVNVDSTRKKVTYLIPLAEIMYSFFDKLKSCSKGYATLDYEILDYRKQDLVKVDILLNGNKVDALSTIMHREFASDRSRKICLKLKEHIPKHQFEIPIQAVIGGKIIARETVSAMRKNVLAKCYGGDITRKKKLLEQQKEGKKRLKAIGNVSVPHDTFVKILSEE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RR11_CHAGL
Sequence: MPKPSKKINLRKIKKKVPKGVIHIQASFNNTIVTITDVRGQVISWSSAGACGFKGAKKSTPFAAQTAAEKALRPLIDQGMRQAEVMISGPGRGRDTALRIIRKSGITLNFVRDVTPIPHNGCRPPSKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SUCC_ALIFM
Sequence: MNLHEYQAKQLFAEFGLPVPEGYACDTPQEAFEAAGRISTAKKVVKCQVHAGGRGKAGGVELHDTKEGVKEFAQKWLGKNLVTFQTDANGQPVSKILVEEASNIANELYLGAVVDRASQRIVFMASTEGGVDIEKIAEETPELIHKAAIDPLVGPQAYQGRELAFKLGLEGDQIKQFVKIFMGLGNMFAQYDLALLEINPLVVTAEGSLLCLDGKINIDSNAMYRQPKLREMHDPSQEDEREAHAAQWELNYVALDGSIGCMVNGAGLAMGTMDIVNLHGGQPANFLDVGGGATKERVTEAFKIILSDSNVKAVLVNIFGGIVRCDLIADGIIGAVEEVGVEVPVVVRLEGNNAPLGSQKLAESGLNIIAATSLTEAAEKVVAAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RL9_GEOUR
Sequence: MKVILKENIENLGHIGDIVKVAPGYARNYLLPKGFALEATTKNAKALDHAKKHLEYKKNKVLEQARVLAAKIEGLALNLSHQAGEEGKLFGAVTNMELAEQMKAQGIEIDRKKIILAEPIKHLGEFTATVKIHPEVNATLKVTVSKA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y805_HAES1
Sequence: MLCAIYKTKRKEGMYLYIEKRGHFDSVPSSLLESFGKPIFVMLFNLAGQKSLINANNEDVQQQIKQNGFYLQMPKQQENLLEQERQYLKHNK
What are the official names of this protein?
YcgL domain-containing protein HS_0805.
Protein: RIMP_BACCR
Sequence: MDKKVTEVVEAFAQPIVEELNLELVDVEYVKEGQDWFLRVFIDSEKGVDIEECGAVSERLSEALDKEDPIPHLYFLDVSSPGAERPLKKEKDFQQAVGKQVAIKTYEPIDGEKMFEGKLLSYDGTTITLLLTIKTRKKEIQISMDKVANARLAVTF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILEUA_RAT
Sequence: MEQLSSANSLFALELFHTLSESSPTGNIFFSPFSISSALAMVFLGTKGTTAAQLSKTFHFDSVEDVHSRFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLPEFLTSTQKMYGADLAPVDFQHASEDARKEINQWVKGQTEGKIPELLAVGVVDSMTKLVLVNAIYFKGMWEEKFMKQDTTDAPFRLNKKNTKSVKMMYQKKKFFFGYISDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLKKIEEQITLEKLREWTKRENLENIDVHVKLPRFKIEESYILNSNLGRLGLQDLFNSSKADLSGMSGSRDLFISKIVHKAFVEVNEEGTEAAAATAGIATFCMLLPEEEFTADHPFIFFIRHNPTANVLFLGRVCSP
What is the function of this protein?
Regulates the activity of the neutrophil proteases.
What are the official names of this protein?
Leukocyte elastase inhibitor A, Serine protease inhibitor EIA, Serpin B1a.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cytolytic granule. Early endosome.
Protein: MNMC_YERPA
Sequence: MNQRPIQTATLSWNEQGTPVSEQFGDIYFSNEDGLEETHHVFLKGNGFPARFASHPQQSCIFAETGFGTGLNFLTLWRDFALFRQQSPNATLRRLHYISFEKYPLHVADLASAHARWPELASFAEQLRAQWPLPLAGCHRILLADGAITLDLWFGDVNTLLPTLDDSLNNQVDAWFLDGFAPAKNPDMWNEQLFNAMARMTRPGGTFSTFTAAGFVRRGLQQAGFNVTKVKGFGQKREMLTGTLPQQIHAPTAPWYHRPAATRCDDIAIIGGGIVSALTALALQRRGAVVTLYCADAQPAQGASGNRQGALYPLLNGKNDALETFFTSAFTFARRQYDQLLEQGIAFDHQWCGVSQLAFDDKSRGKIEKMLHTQWPVEFAEAMSREQLSELAGLDCAHDGIHYPAGGWLCPSDLTHALMMLAQQNGMTCHYQHELQRLKRIDSQWQLTFGQSQAAKHHATVILATGHRLPEWEQTHHLPLSAVRGQVSHIPTTPVLSQLQQVLCYDGYLTPVNPANQHHCIGASYQRGDIATDFRLTEQQENRERLLRCLPQVSWPQQVDVSDNQARCGVRCAIRDHLPMVGAVPDYAATLAQYQDLSRRIQHGGESEVNDIAVAPVWPELFMVGGLGSRGLCSAPLVAEILAAQMFGEPLPLDAKTLAALNPNRFWIRKLLKGRPVQTRSPATQESSR
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y850_AQUAE
Sequence: MALKKLRFEDILLGLTLSLTFLYPLIITLIILYQDAKRKEKEMKIFQKVENIFLSKRCRERILEIVPYLEFVSDSFIEKLIKVCEFTSGKKPKDKEYKNLEEESLYLIELERGTLKVLGKWISDEEFKLLLITYEPKT
What are the official names of this protein?
Uncharacterized protein aq_850.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TORA_SHEMA
Sequence: MNRRDFLKGIASSSFVVLGGSSVLTPLNALAKAGINEDEWLTTGSHFGAFKMKRKNGVIAEVKPFDLDKYPTDMINGIRGMVYNPSRVRYPMVRLDFLLKGHKSNTHQRGDFRFVRVTWDKALTLFKHSLDEVQTQYGPSGLHAGQTGWRATGQLHSSTSHMQRAVGMHGNYVKKIGDYSTGAGQTILPYVLGSTEVYAQGTSWPLILEHSDTIVLWSNDPYKNLQVGWNAETHESFAYLAQLKEKVKQGKIRVISIDPVVTKTQAYLGCEQLYVNPQTDVTLMLAIAHEMISKKLYDDKFIQGYSLGFEEFVPYVMGTKDGVAKTPEWAAPICGVEAHVIRDLAKTLVKGRTQFMMGWCIQRQQHGEQPYWMAAVLATMIGQIGLPGGGISYGHHYSSIGVPSSGAAAPGAFPRNLDENQKPLFDSSDFKGASSTIPVARWIDAILEPGKTIDANGSKVVYPDIKMMIFSGNNPWNHHQDRNRMKQAFHKLECVVTVDVNWTATCRFSDIVLPACTTYERNDIDVYGAYANRGILAMQKMVEPLFDSLSDFEIFTRFAAVLGKEKEYTRNMGEMEWLETLYNECKAANAGKFEMPDFATFWKQGYVHFGDGEVWTRHADFRNDPEINPLGTPSGLIEIFSRKIDQFGYDDCKGHPTWMEKTERSHGGPGSDKHPIWLQSCHPDKRLHSQMCESREYRETYAVNGREPVYISPVDAKARGIKDGDIVRVFNDRGQLLAGAVVSDNFPKGIVRIHEGAWYGPVGKDGSTEGGAEVGALCSYGDPNTLTLDIGTSKLAQACSAYTCLVEFEKYQGKVPKVSSFDGPIEVEI
What is the function of this protein?
Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.
What are the official names of this protein?
Trimethylamine-N-oxide reductase, TMAO reductase, Trimethylamine oxidase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LFNG_BOVIN
Sequence: MLKRCGRRLLLALAGALLACLLVLTADPPPPPVPAERGRRALRSLAGPSGVATAPGLEAAAAAAPGAPVREVHSLSEYFSLLTRSRRDVGPPPGGAPRPADGPPRPLAEPLAPRDVFIAVKTTKKFHRARLDLLLETWISRHEEMTFIFTDGEDEALARRTGHVVNTNCSAAHSRQALSCKMAVEYDRFIESGRKWFCHVDDDNYVNVRALLRLLGSYPHTQDVYLGKPSLDRPIQATERVSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFMSTAERIRLPDDCTIGYIVEALLGVPLVRCGLFHSHLENLQQVPASELHEQVTLSYGMFENKRNSVHIKGPFSVEADPSRFRSVHCHLYPDTSWCPRSAIF
What is the function of this protein?
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules.  Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.  Decreases the binding of JAG1 to NOTCH2 but not that of DLL1.  Essential mediator of somite segmentation and patterning.
What are the official names of this protein?
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: YBAQ_ECOL6
Sequence: MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLWEVENNMRTQEELGRIETVAEYLARREERAKKVA
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YbaQ.
What is the protein family that this protein belongs to?
Belongs to the VapA/VapI family.
Protein: RS3_SODGM
Sequence: MGQKVHPNGIRLGIVKPWNSTWYANTKEFADNLDSDFKVRQFLTKELSKASVSRLVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSISSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: LEUC_SOLUE
Sequence: MPRTIIEKLWDSHVVHERPGAPTLLFIDLHLVHEVTSPQAFQGLRERGLKVRRPDLTIATADHSIPTTDRSLPIVDEIAAKQLAQLETNCKDFGIRCLGVHSSQQGIVHVIGPELGLTQPGMTVVCGDSHTATHGAFGALAFGIGTSEVEQVLASQCLLQRKSKTFQVKVDGALKAGVSAKDIILALIARIGIGGGTGSVFEYTGSAIRALSVEERMTVCNMSIEGGARAGLIAPDDATFEYLAGRPHAPKGAAWDAAIPRWKQLPTDDGATYDRSVSIDADTLEPMITYGTNPGMGVSINAALPDPSQVSDPMARDSITKALAYMGLEGGKPLVGHPIDVVFIGSCTNSRISDLRTAAGLLKGRKVSPKVRVMVVPGSQEVKRQAIAEGLPEIFRAAGCDYREPGCSMCIAMNGDQLAPGEYSVSTSNRNFEGRQGKGGRTFLASPLTAAASAITGVVTDVRTLL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: ILVD_XANOR
Sequence: MPEYRSKTSTHGRNMAGARALWRATGMQDGDFQKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTALAEHKLDLIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVELCHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVPFGMQDIDRLSKRVPQLCKVAPNTPKYHIEDVHRAGGIMAILGELARGGLLHTTAATVHARTLADAIAHWDVTQTVDENVHTFYKAGPAGIPTQIAFSQATRWDSLDTDRSEGCIRDVAHALSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKSILADEVKAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDKILIDIPNRGINLLISDEALASRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKALLDG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: HIS1_SHESR
Sequence: MTESNRLRIAIQKSGRLSTDSQQLLKSCGVKFSINEQSLIAHADNMPIDLLRVRDDDIPGLVMDGVVDLGIIGENVLEEEQIERQTLNKPAEFVKLRQLDFGACRLSLAVPTEFSYADASSLEGLRIATSYPNLLRRFMQQKGISYRDCMLKGSVEVAPRAGLADGICDLVSTGATLEANGLYETEVIYRSMACVIQSTQTQTPSKQALIDRILSRVNGVIRARESKYILLHAPTETLDQIVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTALGASSILVMPIEKMMG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS2_STRA3
Sequence: MNNKILEQLEFNKVKELILPYLKTEQSQEELSELEPMTEAPKIEKSFNEISDMEQIFVEHHSFGIVSLSSISESLKRLELSADLNIQELLVIKKVLQSSSDMIHFYSDLDNVSFQSLDRLFENLEQFPNLQGSFQAINDGGFLEHFASPELERIRRQLTNSERRVRQILQDMLKEKAELLSENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTVYIEPRAVVTLNEEITQLRADERHEESRILHAFSDLLRPHVATIRNNAWILGHLDFVRAKYLFMSDNKATIPEISNDSTLALINVRHPLLSNPVANDLHFDQDLTAIVITGPNTGGKTIMLKTLGLAQLMGQSGLPVLADKGSKIAVFNNIFADIGDEQSIEQSLSTFSSHMTHIVSILNEADHNSLVLFDELGAGTDPQEGASLAMAILEHLRLSNIKTMATTHYPELKAYGIETNFVENASMEFDAETLSPTYRFMQGVPGRSNAFEIASRLGLAPFIVKQAKQMTDSDSDVNRIIEQLEAQTLETRRRLDHIKEIEQENLKFNRAVKKLYNEFSHERDKELEKIYQEAQEIVDMALNESDTILKKLNDKSQLKPHEIIDAKAQIKKLAPQVDLSKNKVLNKAKKIKAARAPRIGDDIIVTSYGQRGTLTSQLKDGRWEAQVGIIKMTLTQDEFTLVRVQEEQKVKSKQINVVKKADSSGPRARLDLRGKRYEEAMQELDNFIDQALLNNMGQVDIIHGIGTGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: ATPE_YERPY
Sequence: MAAMTYHLDVVSAEKKMFSGVVQKIQVTGSEGELGIFPGHAPLLTAIKPGMIRIVKQFGEEEFIYLSGGILEVQPSVVIVLADTAIRGLDLDEARALESKRKAEAHINNSHGDVDYAQASAELAKAIAKLRVIELTKKAM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: METK_BACAN
Sequence: MTKKRHLFTSESVTEGHPDKICDQISDSILDAILSKDANARVACETTVTTGLVLVAGEITTSTYVDIPKIVRETIQGIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDQALEAREGQMTDAEIEAIGAGDQGLMFGFACNETQELMPLPISLAHKLARRLTEVRKNDTLSYLRPDGKTQVTVEYDENGKPVRVDTIVISTQHHPDVTWEEIDRDLKEHVIKAVVPAELIDGETKFFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAGLAEKAEVQLAYAIGVAQPVSISVDTFGTGKVSEDVLVELVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDVDLSWERTDKAAALKEQAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXK_ESCF3
Sequence: MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMQVVVVSADSVNVISHSRVKTDLKGTGDLFCAQLISGLLKGKELTDAVHSAGLRVLEVMRYTQQYDSDELILPPLAEA
What is the function of this protein?
B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i. e.  PNP, PLP and PMP.
What are the official names of this protein?
Pyridoxine/pyridoxal/pyridoxamine kinase, PN/PL/PM kinase, B6-vitamer kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxK subfamily.
Protein: PNRC2_RAT
Sequence: MGGGERYNIPDPQSRNASKNQQQHNRQKTKDQNSQMKIVHKKKERGHGYNPSAVQNGGKTKSLSNNSNWNASLSSPSLLFKSQASQNYAGAKFSEPPSPSVLPKPPSHWVHVSLNPSDKETMTFQLKTLLKVQV
What is the function of this protein?
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery.  May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs.  Required for UPF1/RENT1 localization to the P-body.  Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay.  Also acts as a nuclear receptor coactivator.  May play a role in controlling the energy balance between energy storage and energy expenditure.
What are the official names of this protein?
Proline-rich nuclear receptor coactivator 2.
What is the protein family that this protein belongs to?
Belongs to the PNRC family. PNRC2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, P-body.
Protein: DHA2_STAAR
Sequence: MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALHL
What is the function of this protein?
May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.
What are the official names of this protein?
Alanine dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
Protein: GNAI1_RAT
Sequence: MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDAARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades.  The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state.  Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:19703466, PubMed:24596087, PubMed:25037222).  The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:21158412).  Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:21158412).  Signaling is mediated via effector proteins, such as adenylate cyclase.  Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19703466).  The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane.  Required for normal cytokinesis during mitosis (PubMed:16870394).  Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-1, Adenylate cyclase-inhibiting G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane.