PharMolix/UniProtQA huggingface dataset:
Protein: YCSE_BACSU
Sequence: MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGVYVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDLRNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEITNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMGNAQDIVKETADYITDTNIEDGVAKAIRHWVL
What is the function of this protein?
Catalyzes the dephosphorylation of the riboflavin precursor 5-amino-6-(5-phospho-D-ribitylamino)uracil and of flavin mononucleotide (FMN) in vitro (PubMed:26316208).  To a lesser extent, may also catalyze the dephosphorylation of a broad range of substrates such as phosphorylated sugars and triphosphate nucleotides in vitro (PubMed:26316208, PubMed:25848029).
What are the official names of this protein?
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YcsE.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: ILVC_CORGL
Sequence: MAIELLYDADADLSLIQGRKVAIVGYGSQGHAHSQNLRDSGVEVVIGLREGSKSAEKAKEAGFEVKTTAEAAAWADVIMLLAPDTSQAEIFTNDIEPNLNAGDALLFGHGLNIHFDLIKPADDIIVGMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGTAQALTLSYAAAIGGARAGVIPTTFEAETVTDLFGEQAVLCGGTEELVKVGFEVLTEAGYEPEMAYFEVLHELKLIVDLMFEGGISNMNYSVSDTAEFGGYLSGPRVIDADTKSRMKDILTDIQDGTFTKRLIANVENGNTELEGLRASYNNHPIEETGAKLRDLMSWVKVDARAETA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: BMP2_DAMDA
Sequence: MVAGTRCLLALLLPQVLLGGAAGLIPELGRRKFAASWPGRSSSQPSDDVLSEFELRLLSMFGLKQRPTPSRDPVVPPYMLDLYRLHSGQPGAPAPGHRLERAASLANTVRTFHHEESLEELPEMSGKTTRRFFFNLTSIPTEEFITSAELQVFGKHMPEALENNSSFHHRINIFEIIKPATANSKFPVTRLLDTRLVTQNASRWESFDVTPAVMRWTAQGLTNHGFVVEVAHPEDSYGASKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHRREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
What is the function of this protein?
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis.  Induces cartilage and bone formation.  Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2.  Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A.  In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.  Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation.  Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation.
What are the official names of this protein?
Bone morphogenetic protein 2, BMP-2.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: ASIP_MACMU
Sequence: MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIMALNKNSKEISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: TL17_SPIOL
Sequence: ANQRLPPLSNDPDRCERAFVGNT
What are the official names of this protein?
Thylakoid lumenal 17.4 kDa protein, P17.4.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: RL34_TRIL1
Sequence: MKRTFQPSNTSRKRTHGFLVRMASKNGRLVIKRRRAKGRKRLSVQVASK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: TVAZ2_HUMAN
Sequence: MKLVTSITVLLSLGIMGDAKTTQPNSMESNEEEPVHLPCNHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILRD
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 26-2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: LOX12_RAT
Sequence: MGRYRVRVVTGAWLFSGSVNLVRLWLVGAHREARLELQLRPARGKEEEFDFDVAEDLGPLQFVKLHKEHTVVDDAWFCNLITVQGPGMSAEAVFPCYRWVQGEGILRLPEGTARLAGDNALDVFQKHREKELKERQQTYRWATWKQGLPQTIAADCKDDLPPNMRFHEEKRLDFEWTLKAGVLEMGLKRVYTLLRSWNRLEDFDQIFWGQKSALAEKVHRCWQEDELFGYQFLNGANPMLLRRSTSLPSRLVLPPGTEELQAQLEKELKDGCLFEADFILLDGIPANVIRGEQQYLAAPLVMLRMDPSGKLLPMAIQIQPPNPSSPAPTLFLPSDPPLAWLLAKIWVRNSDFQLQELQFHLLNTHLVAEVIAVATMRCLPGLHPIFKLLVPHIRYTMEINTRSRTQLISDGGIFDQVVSTGGGGHVQLLTRAVAQLTYCSLCPPDDLATRGLLRVPSALYAQDALQLWEVTARYVNGMVHLFYQSDDIVRGDPELQAWCREITEVGLCHAQDRGFPVSFQSRAQLCHFLTMCVFTCTSQHAAINQGQLDWYGWVPNAPCTMRMPPPTSKDDVTMETIMGSLPDVQKSCLQMTITWHLGRLQPDMVPLGHHKEKYFSDPRTKAVLSQFQADLENLEKEITARNQQLDLPYEYLKPSRIENSITI
What is the function of this protein?
Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512).  Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE.  Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation.  It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA.  Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets (By similarity).  An additional function involves a multistep process by which it transforms leukotriene A4/LTA4 into the bioactive lipids lipoxin A4/LXA4 and lipoxin B4/LXB4, both are vasoactive and LXA4 may regulate neutrophil function via occupancy of specific recognition sites (PubMed:23382512).  Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to (13S)-hydroperoxyoctadecadienoate/ (13S-HPODE) (By similarity).  Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin beta-1 (known to affect tumor cell migration and proliferation), it can be regarded as protumorigenic.  Important for cell survival, as it may play a role not only in proliferation but also in the prevention of apoptosis in vascular smooth muscle cells (By similarity).
What are the official names of this protein?
Polyunsaturated fatty acid lipoxygenase ALOX12, Arachidonate (12S)-lipoxygenase, 12S-LOX, 12S-lipoxygenase, Arachidonate (15S)-lipoxygenase, Linoleate (13S)-lipoxygenase, Lipoxin synthase 12-LO, Platelet-type lipoxygenase 12.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
Protein: RL35_THET8
Sequence: MPKMKTHKGAKKRVKITASGKVVAMKTGKRHLNWQKSGKEIRQKGRKFVLAKPEAERIKLLLPYE
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: MPK2_ARATH
Sequence: MATPVDPPNGIRNQGKHYFSMWQTLFEIDTKYVPIKPIGRGAYGVVCSSVNRESNERVAIKKIHNVFENRIDALRTLRELKLLRHLRHENVVALKDVMMANHKRSFKDVYLVYELMDTDLHQIIKSSQVLSNDHCQYFLFQLLRGLKYIHSANILHRDLKPGNLLVNANCDLKICDFGLARTSNTKGQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPVFPGTECLNQIKLIINILGSQREEDLEFIDNPKAKRYIESLPYSPGISFSRLYPGANVLAIDLLQKMLVLDPSKRISVTEALQHPYMAPLYDPSANPPAQVPIDLDVDEDEDLGAEMIRELMWKEMIHYHPEAATINNNEVSEF
What are the official names of this protein?
Mitogen-activated protein kinase 2, AtMPK2, MAP kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: DUT_SHEB5
Sequence: MKTPIELKILDSRIGSEFPLPAYATPGSAGMDLRAMIDTTLTIAPGETVLIPTGIAIHVADQGLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRSDSPFALEIGDRLAQLVFVPVVQAQFKLVDEFDSSDRGEGGFGHSGTK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: DAPA_MYCLE
Sequence: MTTVGFDVPARLGTLLTAMVTPFDADGSVDTAAATRLANRLVDAGCDGLVLSGTTGESPTTTDDEKLQLLRVVLEAVGDRARVIAGAGSYDTAHSVRLVKACAGEGAHGLLVVTPYYSKPPQTGLFAHFTAVADATELPVLLYDIPGRSVVPIEPDTIRALASHPNIVGVKEAKADLYSGARIMADTGLAYYSGDDALNLPWLAVGAIGFISVISHLAAGQLRELLSAFGSGDITTARKINVAIGPLCSAMDRLGGVTMSKAGLRLQGIDVGDPRLPQMPATAEQIDELAVDMRAASVLR
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_ONYJA
Sequence: TYYTPEYQTKDTDILAAFRMTPQPGVPAEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEENQYIAYVAYPLDLFEEGSVTNMLTSIVGNVFGFKALRALRLEDLRIPPAYSKTFIGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEALFKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGAPIVMHDYLTGGFTANTSLAYYCRDNGLLLHIHRAMHAVIDRQRNHGIHFRVLAKALRMSGGDHIHAGTVVGKLEGEREVTLGFVDLLRDDYIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVASEACVQALNEGLR
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YJFJ_ECOL6
Sequence: MGILKSLFTLGKSFISQAEESIEETQGVRMLEQHIRDAKAELDKAGKSRVDLLARVKLSHDKLKDLRERKASLEARALEALSKNVNPSLINEVAEEIARLENLITAEEQVLSNLEVSRDGVEKAVTATAQRIAQFEQQMEVVKATEAMQRAQQAVTTSTVGASSSVSTAAESLKRLQTRQAERQARLDAAAQLEKVADGRDLDEKLAEAGIGGSNKSSAQDVLARLQRQQGE
What are the official names of this protein?
Uncharacterized protein YjfJ.
What is the protein family that this protein belongs to?
Belongs to the PspA/IM30 family.
Protein: RNPA_BACVZ
Sequence: MKKRNRLKKNEDFQKVFKRGTSMANRQFVLYTLDQPKQEELRVGLSVSKKIGNAVVRNRVKRLIRQAVQEEKELLKPKDFIIIARKPAGDLSFEETKKSLQHLFRKTSLYKKSSSK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RL20_STRM5
Sequence: MARVKRGVQARRRHKKILDLAKGYYNARRKVFRVAKQAVIKAQQYAYIGRKQKKRNFRSLWITRINAAARINGLSYSRFMNGLLKAGITLDRKVLADIAVHDAAGFTALAEKAKGALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: ATPI_SACOF
Sequence: MNITPCSIKTLKGLYDISGVEVGQHFYWQIGGFQIHAQVLITSWVVITILLGSVIIAVRNPQTIPTDGQNFFEYVLEFIRDLSKTQIGEEYGPWVPFIGTMFLFIFVSNWSGALLPWKIIELPHGELAAPTNDINTTVALALLTSAAYFYAGLSKKGLSYFEKYIKPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, chloroplastic, ATP synthase F0 sector subunit a, F-ATPase subunit IV.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ZN322_MACFA
Sequence: MYTSEERCNQRTQKRKIYNVCPQKGKKIFIHVHAITQIDGHIYQCLECKQNFCENLALIMCERTHTGEKPYKCDMCEKTFVQSSDLISHQRIHNYEKPYKCSKCEKSFWHHLALSGHQRTHAGKKFYTCDICGKNFGQSSDLLVHQRSHTGEKPYLCSECDKCFSRSTNLIRHRRTHTGEKPFKCLECEKAFSGKSDLISHQRTHTGERPYKCNKCEKSYRHRSAFIVHKRVHTGEKPYKCGACEKCFGQKSDLIVHQRVHTGEKPYKCLECMRSFTRSANLIRHQATHTHTFKCLEYEKSFNCSSDLIVHQRIHMEEKPHQWSTCESGFLLGMDFVAQQKMRTQTEELHYKYTVCDKSFHQSSALLQHQTVHTGEKPFICNVSEKGLELSPPHASEASQMS
What is the function of this protein?
Transcriptional activator.  Important for maintenance of pluripotency in embryonic stem cells.  Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes.  Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly.  Promotes inhibition of MAPK signaling during embryonic stem cell differentiation.
What are the official names of this protein?
Zinc finger protein 322, Zinc finger protein 322A.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly found in the nucleus.
Protein: EXOC5_MOUSE
Sequence: MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAADVIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEVSRMREVAAVLLHFKGYSHCIDVYIKQCQEGAYLRNDIFEDAAILCQRVNKQVGDIFSNPEAVLAKLIQSVFEIKLQSFVKDQLEECRKSDAEQYLKSLYDLYTRTTGLSSKLMEFNLGTDKQTFLSKLIKSIFISYLENYIEVEIGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIRQRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTILVEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLISSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDENNVLIQYTNACVKVCVYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLIYEHLQQYSYSCMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLANLDKNILHSFVQLRADYRSARLARHFS
What is the function of this protein?
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
What are the official names of this protein?
Exocyst complex component 5, Exocyst complex component Sec10.
What is the protein family that this protein belongs to?
Belongs to the SEC10 family.
What are the subcellular locations of this protein?
Cytoplasm. Midbody. Note=Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3.
Protein: ILDR1_MOUSE
Sequence: MGCGLLAAGLLLFTWLPAGCLSLLVTVQHTERYVTLFASVTLKCDYTTSAQLQDVVVTWRFKSFCKDPIFDYFSASYQAALSLGQDPSNDCSDNQREVRIVAQRRGQSEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCTIEAPGDTSGDPDKEVKLIVLHWLTVIFIILGALLLLLLIGVCWCQCCPQYCCCYIRCPCCPTRCCCPEEALARHRYMKQVQALGPQMMEKPLYWGADRSSQVSSYAMNPLLQRDLSLQSSLPQMPMTQMAAHPPVANGVLEYLEKELRNLNPAQPLPADLRAKSGHPCSMLSSLGSAEVVERRVIHLPPLIRDPPSSRTSNPSHQQRLNAVSSRHCDLSERPRQRHHSDFLRELQDQGMRPWAPGRGELDPHWSGRHHRSRPSESSMPWSDWDSLSECPSSSEAPWPPRRPEPREGAQRRERRRHRSYSPPLPSGPSSWSSEEEKESLPRNWGAQRRHHHRRRRSQSPNWPEEKPPSYRSLDVTPGKNNRKKGNVERRLERESSHSGRSVVI
What is the function of this protein?
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027).  Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs (PubMed:25217574).  Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine (PubMed:23863714).  In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060).
What are the official names of this protein?
Immunoglobulin-like domain-containing receptor 1, Angulin-2.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. LISCH7 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Nucleus. Note=Localizes to tricellular tight junctions (tTJs) between epithelial cells.
Protein: ALBA_METMP
Sequence: MDNIVYVGNKGVMNYVLAVITQFNSENAQEVIVKARGKAISRAVDVEEMVTKRFMPEVKIKEINLGTDHIQGEDGKSINVSTIEIILFK
What is the function of this protein?
Binds double-stranded DNA tightly but without sequence specificity.  It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture.  However, it does not significantly compact DNA.  Binds rRNA and mRNA in vivo.  May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
What are the official names of this protein?
DNA/RNA-binding protein Alba.
What is the protein family that this protein belongs to?
Belongs to the histone-like Alba family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: BETI_BRUA2
Sequence: MPKIGMEPLRRRELIDAAIRTIGQRGSLDVTVAQIAHEAGVSPALAHHYFGGKDKLILATMRHLLRELGRDLNVAIKQANTPHERIAAIIAVNFSATQFAQETIAAWLTFYVHAQQSDDIKRLLRIYARRLHSNLVFALEQLTSRARANRIAEGAGAMIDGLYIRHALGADAPDAASAIALVEDYIAIQLSGQPSAEN
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: TRPB_PROM4
Sequence: MTSTLPSQPKDMELANSSRPSVHGRFGRFGGQYVPETLMPALAELEKKAAEAWQDSSFTNELSHLLKTYVGRATPLYEAKRLSQHYMSREGGPRIWLKREDLNHTGAHKINNALGQALLAIRMGKKRIIAETGAGQHGVATATVCARFGLECVIYMGQEDMERQALNVFRMKLLGAKVQSVTAGTATLKDATSEAIRDWVTNVESTHYILGSVAGPHPYPMLVRDFHSVIGEETKQQCKEAFGRSPDVLLACVGGGSNAMGLFHSFIEDLSVKMIGVEAAGDGVNTKRHAATITQGSVGVLHGAMSLLLQDSDGQVQEAHSISAGLDYPGVGPEHSYLNEIGRAEYVAVTDKEALNALELVSKLEGIIPALETAHAFAWLDTLCPSLAPGTEIVINCSGRGDKDVNTVAKKMGFEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: SURE2_BURL3
Sequence: MRILLSNDDGYLAPGLAALSDALQPLAELTVIAPEQNCSGASNSLTLSRPLSVQRAASTGFFYVNGTPTDSVHVALTGMADARPDLVVSGINNGQNMGEDTLYSGTVAAATEGIMFGVPAIAFSLVDKGWAHLPDAARVAAEIVKHYLAHPLPGQPLLNVNIPNLPYDELKGWKVTRLGKRHPSQPVIRQTDPRGEPIYWIGAAGEALDASDGTDFHAVANGFVSITPLQLDLTHTQMLPATREWARAGGRAS
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE 2, Nucleoside 5'-monophosphate phosphohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNW_PSEE4
Sequence: MSNAPILLTPGPLTTSTRTRQAMLVDWGSWDRDFNQLTASVCEQLLAIIDGSASHHCVPLQGSGTFAVEAAIGTLVPRDGKVLVLINGAYGQRLAKICKVLGRTFSTFETAEDQPTTAEDVDRLLAADPAVTHVALIHCETSTGILNPLPEIAQVIQRHGKRLIIDAMSSFGALPIDAREVPFEALIAASGKCLEGVPGMGFVFAEKTALAAAEGNAHSLAMDLQDQHAYMAKTGQWRFTPPTHVVAALHEALLQYNEEGGLPARHQRYQDNCQTLLDGMAKIGLHSFLPAEIQAPIIVTFHAPKDPRYQFKDFYERVKAKGFILYPGKLTQVETFRVGCIGVVGAAGMQAAVDAVAEVLREMEVLDI
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: AGD15_ARATH
Sequence: MNRKASVSKELNAKHSKILEALLKHPDNRECADCRSKAPRWASVNLGIFICMQCSGIHRSLGVHISQVRSITLDTWLPDQVAFMKSTGNAKGNEYWESELPQHFERSSSDTFIRAKYSEKRWVSPGAIQPAPIVSQLSCKVSHLVESGYKPETPKKARTLSLDEEILLHHVLQVTPPETRTRAGSVDMKENVYVVPLPEFKKPNQKNENFSSEVNQNRRTTIAPPSSWATFD
What is the function of this protein?
GTPase-activating protein (GAP) for ADP ribosylation factor (ARF).
What are the official names of this protein?
Probable ADP-ribosylation factor GTPase-activating protein AGD15, ARF GAP AGD15, Protein ARF-GAP DOMAIN 15, AtAGD15.