PharMolix/UniProtQA huggingface dataset:
Protein: ARSK_RAT
Sequence: MLLLLVSVIVALALVAPAPETQEKRLQVAQAPNVVLVASDSFDGRLTFQPGSQVVKLPFINFMRARGTTFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVMEKHGYQTQKFGKLDYSSGHHSISNRVEAWTRDVAFLLRQEGRPIINLIPDKNRRRVMDKDWQNTDKAIAWLRQVNSTKPFVLYLGLNLPHPYPSPSSGENFGSSTFHTSLYWLEKVAYDAIKIPKWLALSEMHPVDYYSSYTKNCTGKFTENEIKNIRAFYYAMCAETDAMLGEIILALHKLNLLQKTIVIYTSDHGEMAMEHRQFYKMSMYEASAHVPILMMGPGIKANLQVPSLVSLVDIYPTMLDIAGIPLPLNLSGYSLLPLSSNTSANDQAFRVHHPPWILSEFHGCNANASTYMLRTGQWKYIAYSDGTLVQPQLFDLSLDPDELTNIATEFPEITYSLDQQLRSVINYPKVSASVHRYNKEQFIMWKQSVAQNYSNYIAHLRWHQDWQKDPRKYENAIQRWLAIHSSPPTHSPLSLVHQWLTTHSSPIAVDNKKTFSSYT
What is the function of this protein?
Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity).  Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity).  Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity).
What are the official names of this protein?
Arylsulfatase K, ASK, Glucuronate-2-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Secreted. Lysosome.
Protein: GSTM7_RAT
Sequence: MPMTLGYWDIRGLAHAIRLLLEYTDSSYEEKRYTMGDAPDFDRSQWLNEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLGRKHNLCGETEEERIRVDILENQLMDNRMVLARLCYNPDFEKLKPGYLEQLPGMMRLYSEFLGKRPWFAGDKITFVDFIAYDVLERNQVFEATCLDAFPNLKDFIARFEGLKKISDYMKSSRFLPRPLFTKMAIWGSK
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase Mu 7, Chain 4, GST Yb3, GST class-mu 3, Glutathione S-transferase Yb-3.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Mu family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM10_GIBZE
Sequence: MDLDPAHKPSQAEETKEQGNEQGQVEQNQAQQDPTTGPQAETEKAIIPSQGSTIPQKRSAEDEPAQPMSKNALKRLRKQQQWEAGKEDRKLKRKDSRIARKVRKREERDALIAQGINPYANKQKPPSVNVPISLIFDCEFEQYMREKEIISLGSQITRSYSENKNAKYRTNIYVSNWNGKLAERFHQILDDKHQNWKGIDFVEGDFIECAEKAREKMKHENMIEPLQRSLTEKSPWARDEKDPLPLPDPEPEPRPEYSDIVYLSSDSPYTLERLEPNTSYVIGGLVDKNREKGLCYKRARERGIRTARLPIGQYMVMQSRTVLTTNHVVEIMLKWLEYENWGEAFMSVIPKRKGGKLKEQQGASGETQETEEAEAEDPEEENEETKDPDAEASASKQNTPKVEVTSK
What is the function of this protein?
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.
What are the official names of this protein?
tRNA (guanine(9)-N1)-methyltransferase, tRNA methyltransferase 10, tRNA(m1G9)-methyltransferase, tRNA(m1G9)MTase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYM_VIBCH
Sequence: MANDPRKLLVTCALPYANGSIHLGHMLEHIQADIWVRYQRLRGNTVNFICADDAHGTPIMLKAQQMGMTPEAMIEMVSEEHQRDFAGFDISFDNYHSTHSDENRELASHIYLQLKKNGFISSRTISQLFDPEKEMFLPDRFVKGTCPKCKSEDQYGDNCDACGETYSPTELINPKSAVSGATPVMKDSEHFFFDLPQFESMLKEWTRSGSLQSETANKMQEWFEGGLQQWDISRDAPYFGFEIPGEKDKFFYVWLDAPIGYMGSFKNLCDKRGDLDFNEYWNKDSKTELYHFIGKDIVYFHSLFWPAMLDGSGFRKPTNVFVHGYVTVNGAKMSKSKGTFVKASTYLNHLDPECLRYYYAAKLNNRIDDLDLNLEDFTQRVNADVVNKIVNLASRNAGFITKRFDGKLSAHFAEPELYAEFAGAADRIAELFEAREFGRAIREITALADKANQYVDEKAPWVVAKQEGQDQALQDICTVGINLFRVLMTYLKPVMPALAERTEAFLNQELTWEGVATPLTDHAVTPFKALFNRIDPKQVEAMIEASKAEAAAEKAAADAAKPKSAETELSKDPLAAEIEFDDFAKVDLRIAKILSCEAVEKSDKLLKFELDIGGETRQVFSGIKSAYQPEDLIGKYTVVVANLKPRKMKFGMSEGMILAAGPGGSDLWLLEPHQGAQAGMRVM
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ4_SCLS1
Sequence: MSLSLSPGLYTQAARLPRELLTVCSITIATRSFSVLHRPTPNYPGHVPLTSIERSGLAVGSAIMAFFNPYRADLIAACGEATATPYFIYRLRDAMLSSPTGRRILRDRPRISSKTLSMQHLRTLPTNAVGRCYADWLDREGVSPDTRDSVKYIDDEECAYVMQRYRECHDFYHAITGLPIVREGEVALKAFEFANTLLPMTGLSMFAVMSLKPAERRRFFTIYAPWALTNGLKADELINVYWEEQLERSVEELREELGIEKPLDLREIRRAEKERKKAQKAT
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein coq4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RL332_STAAM
Sequence: MRVNVTLACTECGDRNYITTKNKRNNPERIEMKKYCPRLNKYTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: UVRC_CITBB
Sequence: MITQAMIENFPPSPGVYLMKSADDTVIYVGKARNLKKRVRSYAGDTRDSRIHIRFMVQLVHSVDYLVTDTEKEALILENTLIKQHRPKYNINLRDDKTYFSLRMDMKEQFPRLSIVRKIPSDGARYFGPYASATAAKEVLKQLYKMFPLRHYPLATCMARKRPCLYHQIKQCSAPCCGLISAAEYAALAHGAALFLEGKNTEVARLYRSKMNLAAEQMRYEDAARYRDLLRAIEVTVERQKMVAQSDDSDVFGLHREADRMQIALLHIRGGTLTGGRSFLFDWELETEEGLASFLNEYYDLDAPIPPQVLIPVPIAEPAALEELLSEKAGKKVTIAVPQRGPKLEMVKLAGKNAETAAQERLARESSSATLLTELAEKLNLPHPPRRIECYDISNIQGEMAVGSRVVFIDGRADKSLYRRYRIKGVLQSDDFAMMREVLSRRFKAESSEEKPDLIVVDGGLGQLGVLNAVLDELEVTGVEAAGLAKSRVARDMESEEIERSDERVFRPGRKNAIALRQSSAPLLLLVRIRDEAHRFAVTYHKDVRSKVLTGSELDGVAGIGEKRKKALLKHFGSLKRVKEATLEELKGAPGMTESAAKALVERLHGSPLPNPPPPGEGAMDRK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYFP1_HUMAN
Sequence: MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS
What is the function of this protein?
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression.  In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1.  Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity).  Regulates formation of membrane ruffles and lamellipodia.  Plays a role in axon outgrowth.  Binds to F-actin but not to RNA.  Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex.  Actin remodeling activity is regulated by RAC1.  Regulator of epithelial morphogenesis.  As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).  May act as an invasion suppressor in cancers.
What are the official names of this protein?
Cytoplasmic FMR1-interacting protein 1, Specifically Rac1-associated protein 1, Sra-1, p140sra-1.
What is the protein family that this protein belongs to?
Belongs to the CYFIP family.
Protein: ALLC_XENLA
Sequence: MFAHPKENIALPVPEFLQMNNLACESVGGKVLFATDDWFAPAEHLLKKTEPEFKVGLFTEFGKWMDGWETRRKRIPGHDWCIIQLGVPGIIHGFEADTRFFTGNYAPRISIQAACLKPEEITLQPREDKIGTAASDEEFKAADKLKSEKWSHLLKMTELKPGYAESSHSYFQVNSKERWTHLRLNIYPDGGIARFKVYGIGQRDWTSCGPNDFEDLLSMVNGGVCLGFSDAHYGHPRNLIGNGRACDMGDGWETARRLDRPPILKADSKGILQVPGFEWAVLKLGHPGLVTHIEIDTNHFKGNSPNSCKIDACALKPTEQEEVKGHGNFEQGYNWKPLLPVTQIHPHKRHFMESTSLALHQVISHVKITIAPDGGVSRIRLWGFPRPLP
What is the function of this protein?
Utilization of purines as secondary nitrogen sources, when primary sources are limiting.
What are the official names of this protein?
Allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: MUTS_CHESB
Sequence: MMQQYIEIKAAHADCLLFYRMGDFYELFFDDAEVASRALGITLTKRGKHRGEDIPMCGVPVHAADDYLQKLIALGHRVAVCEQMEDPAEAKKRGYKAVMRRDVVRLVTPGTITEEKLLDPSEANYLMALGRVKGSEELALAWIDISTGIFRVASTAPDRLLADISRIDPRELIVAEPVYHDAELRPVFDMLGRVVVPQPPVFFDSASAAMRLSRFYGVATLDGFGRFSRAELSAIAGAVAYVEKTQKAERPPLAAPERDEEGKSLFIDPSTRANLELARTLSSSREGSLLKAIDRTVTGAGSRLLAERLMSPLTDPQVIAERLDSVSFFLDEPGLRDRLRAFLKGVPDISRALSRLALNRGGPRDLGALSAGLEAAAAAADLLRGKEAPSEISAALSTLLSLPAALVSHLDRALADDLPLLKRDGGFVRGGYDAELDEMRALRDQSRRVIAGMERDLIEETGIRSLKIRHNNILGYYIEVRANNAGALNGTDEAKARFIHRQTMANAMRFTTTELADLETRIANAADRALAIELAVFERLVGEVVAASEPLRAAAQALAVLDVSAALACLAEGEDYCRPVVDGSLDFHIEGGRHPVVEQALRKQLGEPFVANDCDLSPAEGEKAGAIWLLTGPNMGGKSTFLRQNALIAVLAQMGSFVPARSARIGVVDRLFSRVGASDDLARGRSTFMVEMVETAAILNQAGERSLVILDEIGRGTATFDGLSIAWAAVEYLHEKNRCRALFATHFHEMTALTEKLSRLVNVTMRVKEFEGEVIFLHEVARGAADRSYGIQVARLAGLPQTVVERARDVLHRLEEGETGTKAARIVDDLPLFSAAMRQEPPKSKAPDHLREELTALNPDDMTPREALEVLYKLKRLVIEG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CRYL1_HUMAN
Sequence: MASSAAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ
What is the function of this protein?
Has high L-gulonate 3-dehydrogenase activity.  It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.
What are the official names of this protein?
Lambda-crystallin homolog, L-gulonate 3-dehydrogenase, Gul3DH.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURQ_VIBC1
Sequence: MTNDALIAALAHLVSEGRNPDTMDIDLLPSLDIVQRLNQQDKLVPLAVEKVLPEIALAVDKITDAFKVGGRLVYMGAGTSGRLGVLDASECPPTFGVSDKMVVGLIAGGPEAILKAKEGAEDSPVLGEQDLKDIKFTNLDVVVGIAASGRTPYVIGGLEYANEIGATTIALSCNPDSPIADIADVAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRLGKSYQNLMVDVKATNNKLVARAARIVMQATDCSKEQATEVLKQTDYEVKLAILMILTDLDIESARAHLHHQDGFLRKAVESHQPK
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: C71A6_NEPRA
Sequence: ILIALLCTLPFLFFLKKWRRSYSGKTPPPSPPKLPVLGNLHQLGTFPHRSLQSLSRRYGPVMQLHFGSVPVLVASSPEAAREIMKNQDLNFSNRPNLSIPRRLLYDNHDVAFAPYGEYWRQIRSICVLQLLSNKRVQSFRRVREEETSIMVEKIMQLQKTTPTAAVNLTDLLTCLTNDVFCRIALGKKYGGTTTGDGEYHVRSLKKNLAEFYVLLGISPLWEYIPWLEWTRRFDGVDRRIEEVSRTFDEFLGKVIQEHRVRDKREDTTVVGDTVGLDFVDLLLQFQRENERSSSPVDDLTIKAVILDMFLAGTDTTVTALEWALSELIKNPRAMKILQKEVRGVAGSKGEIEESDLEKMPYLKAVMKESLRLHAPVPLLVPRESTRDTKVLGYDVASGTRVLINCWAIGRDSSVWEESETFLPERFLETSIDYRGMHFELIPFGSGRRGCPGATFAAAIDELALATLVHKFDFKLPNGVRVEDLDMSEGSGFTIHKKFPLLVVPTPHACTS
What are the official names of this protein?
Cytochrome P450 71A6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GATC_BURMS
Sequence: MALTLTDVTRIAHLARLEMADADAERTLTQLNEFFGLVEQMQAVDTTGIAPLAHPIEQILEVAQRLREDAVTEHVNRDDNQRPAPAVQDGLYLVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: IF2_ECOHS
Sequence: MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARAAVRGGKGGKRKGSSLQQGFQKPAQAVNRDVVIGETITVGELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAQVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_POLNA
Sequence: MNKIRKGDEIIVITGRDKGKRGTISLRVDDSYVLVDGINLVKKHTKPNPLKGTTGGIVEKSMPIHQSNVAIFNAASGKADRVGIKLLADGKKTRVFKSSGEEIKAA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: IRF4_HUMAN
Sequence: MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHISNPEDYHRSIRHSSIQE
What is the function of this protein?
Transcriptional activator.  Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter.  Binds the immunoglobulin lambda light chain enhancer, together with PU. 1.  Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.  Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
What are the official names of this protein?
Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TYPH_ECOL6
Sequence: MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAAIKLADKAPESTPTVYRRISE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: CISY_PIG
Sequence: MALLTAAARLFGAKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGNTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGYSIPECQKMLPKAKGGEEPLPEGLFWLLVTGQIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGIHRTKYWELIYEDCMDLIAKLPCVAAKIYRNLYREGSSIGAIDSKLDWSHNFTNMLGYTDAQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPHDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLIKLVDSK
What are the official names of this protein?
Citrate synthase, mitochondrial, Citrate (Si)-synthase.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ADH_DROMD
Sequence: MSLTNKNVVFVAGLGGIGLDTSRELVKRDLKNLVILDRIDNPAAIAELKAINPKVTVTFYPYDVTVPVAETTKLLKTIFAQIKTIDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGSKAAVVNFTSSLAKLAPITGVTAYTVNPGITKTTLVHKFNSWLDVEPRVAEKLLEHPTQTSQQCAENFVKAIELNKNGAIWKLDLGTLESITWTKHWDSGI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: FUT2_BOVIN
Sequence: MFSTQTFFFFPTAPFILFVFTASTIFHLHQRLEKMQPTWELEALEPATMETPSRPQPRPQLKGMWTINAIGRLGNQMGEYATLYALAKMNGRAAFIPPQMHSTLAPIFRITLPVLHDATARSVPWQNYHLNDWMEEQYRHIPGEYVRLTGYPCSWTFYHHLRAEILQEFTLHAHVREEAQNFLRGLRVNGSRPSTYVGVHVRRGDYVHVMPNVWKGVVADRRYLEQALDWFRARYSAPIFVVSSNGMAWCRENINASRGDVVFAGNGNEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGETIYLANYTLPDSPFLKIFKPEAAFLPKWIGIPADLSPLLKH
What is the function of this protein?
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:10814703).  Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs.  Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (By similarity).  Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:20506485).
What are the official names of this protein?
Galactoside alpha-(1,2)-fucosyltransferase 2, Alpha(1,2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, Secretor factor, Se, Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2, Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: PDE3A_MOUSE
Sequence: MAVRGEAAQDLAKPGLGGASPARVARGNHRHRGESSPSPRGSGCCWRALALQPLRRSPQLSSALCAGSLSVLLALLVRLVGGEVGGELEKSQEAAAEEEEEEGARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQLSLGVGDGRLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVAWTSVLRTVALVSLERFKVAWRPYLAYLAAVLGLLLARYAEQILPQCSGPAPPRERFGSQLSARTKEEIPGWKRRRRSSSVVAGEMSGCSGKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKQAISKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPGLTTLTKSRSFTSSYAVSAANHVKAKKQNRPGGLAKISPVPSPSSSPPQGSPASSPVSNSASQQFPESPEVTIKRGPGSHRALTYTQSAPDLSPQIPPPSVICSSCGRPYSQGNPADGPSERSGPAMLKPNRTDDTSQVTSDYETNNNSDSSDILQNEEEAECQREPQRKASACGTYTSQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLMENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKMYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDSDDSGDTDDPEEEEEEAETPHEDEACESSIAPRKKSFKRRRIYCQITQHLLQNHMMWKKVIEEEQCLSGTENQSLDQVPLQHPSEQIQAIKEEEEEKGKPRAEETLAPQPDL
What is the function of this protein?
Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:11420239).  Has also activity toward cUMP (By similarity).  Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway.  E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity.  This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (By similarity).
What are the official names of this protein?
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, Cyclic GMP-inhibited phosphodiesterase A, CGI-PDE A.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm, cytosol.