PharMolix/UniProtQA huggingface dataset:
Protein: CYSG_SHIF8
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDTLNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMSERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: FAR6_NAMOO
Sequence: GRAENFLRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-6, FMRFa-6.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CELF2_XENLA
Sequence: MFERTSKPAFVENICVESMRCPKSAVTMRNEELLFSNGTTNKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKDLFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATTPSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATTTNVNPLSTTASALGALTSPVAASTANSSAGAAMNSLTSLGTLQGLAGATVGLNNINALAGTVNIAQMLSGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY
What is the function of this protein?
RNA-binding protein implicated in the regulation of several post-transcriptional events.  May be involved in pre-mRNA alternative splicing, mRNA translation repression and stability (By similarity).
What are the official names of this protein?
CUGBP Elav-like family member 2, CELF-2, Bruno-like protein 3, CUG triplet repeat RNA-binding protein 2, CUG-BP2, CUG-BP- and ETR-3-like factor 2, ELAV-type RNA-binding protein 3, ETR-3, RNA-binding protein BRUNOL-3.
What is the protein family that this protein belongs to?
Belongs to the CELF/BRUNOL family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: IL17B_HUMAN
Sequence: MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF
What is the function of this protein?
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
What are the official names of this protein?
Interleukin-17B, IL-17B, Cytokine Zcyto7, Interleukin-20, IL-20, Neuronal interleukin-17-related factor.
What is the protein family that this protein belongs to?
Belongs to the IL-17 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DUS2_SCHPO
Sequence: MGLLNYSNKVCLAPMVRIGELPMRLLALRYGANLVWGPEIVDKALLSGTPVERVVNDRINCIDFVKPPSNKVLFRVHPLEANRLIFQLGSASPELAVEAAKLVANDVAGIDLNCGCPKHFSVHAGMGAGLLKNQDRLVSILDALVNEIGKPYKISISCKIRLLETKEDTLKLVERICDTGVRAITVHCRTTPMRNTEPADRSYLSEIVGVCRNKDVSILVNGDVLSYNDGLDVIEKYGVDGVLIARAAERNVSCFRIEGPLSSFKVAEEFLKMALEVDNNFGNTKYCLNQIMQGSFRKNVRQLAQTAKTYEDLKKAFEIEYKHSDASSVCPTLEKEKSLVISFVDLPSFLESLLASNILKQLSRLHFTKIFAVSEEEDICKQLDDIHEKFLCHGIALSLISADNLASAIASAHLVICMEKDESIMNEAVCDQKITIRLPINSNTNEAVVECENKSMQSKHALDIIQERIKDLEEKAQVV
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:34798057).  Also able to mediate dihydrouridylation of some mRNAs, thereby affecting their translation (PubMed:34798057).
What are the official names of this protein?
tRNA-dihydrouridine(20) synthase [NAD(P)+], mRNA-dihydrouridine synthase dus2, tRNA-dihydrouridine synthase 2.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL10_MYCCT
Sequence: MSNSRPAHARKAEIVAEIVSKIKSAQGVAIAEYKHLTVAKMTELRVQALKQNIDIKVYKDSLVRRAVEELGLVDLIPFLTQQNVFIFSNEDSISAAKLVANFAKKNEALKLKAGIYEGKVVDTAGINEVASLPSKEELYSMFASSLLYPLRKVMAAINAVAETRN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: LLDD_HAEIE
Sequence: MIISSASDYREAARRRVPPFMFHYADGGSYAEQTLARNVSDLENIALRQRVLKDMSELDTSIELFGEKLSMPTILAPVGACGMYARRGEVQAAQAADNKGVPFTLSTVSICPIEEVAPAIKRPMWFQLYVLKDRGFMKNALERAKAAGCSTLVFTVDMPTPGARYRDMHSGMSGPYKEIRRVLQGFTHPFWAYDVGIKGKPHTLGNVSTYMGRQIGLDDYIGWLTENFDPSISWKDLEWIREFWEGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVLSSARALPPIADAVKGDIKIIADSGIRNGLDIVRMLALGADATMLGRAFVYALGAAGRQGVENMLDIFKKEMRVAMTLTSNRTIADIKPEALVDLSKL
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CLPP_CHLAT
Sequence: MPIGIPKVAYRIPGESVSTYVDVYNRLYRERILFLGEDLDDEVANQLIGVMVFLNSEDDTKGIFFYINSPGGSMNSGLGVYDMIQHINVDVTTICMGLAASMASFILAGGTPGQRLMFPHARVMLHQPMGGNGGKAKYMVEESVEVKRLRELIAHLYAKRTGQPIERIRIDMNRDNFMRPRAAKEYGLIDHMITHITELDELEKDASDLRRFGGVDLTKLNKQGS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: GLYA_STRPC
Sequence: MTMIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAEGYPGNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTEMLNYEAILEQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVHYAHIVTSTTHKTLRGPRGGLILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQNLLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMGVKESQTIAHLIIKALVNHDQETILEEVRQEVRQLTDAFPLYKK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_METBU
Sequence: MTEISSMVITHAKATVEEMEDSWHGDIDLVLSQLYSNELVYECAVLKTCNRVEIYVVSSKGSSVLFHYAKEMGVSAKIVEFYDHDESLRHLLRLACGLESMIIGEDQILGQIKDFFLMAKGAGTVGKVLSTAFSKAIQVGKRVRTETFINRGAVSIASAAVDLAEDILDGLNDKHILVIGTGEMGTLVTRALSHRDMHVIYLANRTYEKARDLAEELGGEAVMFDQLEKYVRAADVVISATSAPHYVLKGDLVAKVMEGRENELLLIDIASPRDIDPAVEEIPHVILRNIDGLRVINEKNLQMRMVEAKKAEIIIDDELDMVKAQYKRQKADAIISNLYSQSHGLRHNEMEHAINKLSAYHTIGEIERKVLEDLTHAITNKILAEPTKKLRNAAEYDDDKFLDSVSRLFDIRPIKKNDGITK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RRG9_KLULA
Sequence: MFKLCGWLLPRSRTLFELRKAGVMPFHSTALTLSENDKIDSSIKVAEIPKKGKAKRLINTVNRSKDNDGHSTWRDNTALPDWKRQKFALKEKLNGERWNPKKKLSREQMETVRLLKRQFPHMTSGDIAIQMKVSPEVVRRILKSKWEPTEEELEDIQRRWKKRSDRILDLYENGKIDGYTGIIPVTRKVVIGGPNSEHIIHRKKPQQDLGPSNKLHYNKSKHIDRGAVKARNNLHLLLKKKI
What is the function of this protein?
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
What are the official names of this protein?
Required for respiratory growth protein 9, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PI3K2_SOYBN
Sequence: MTGNEFRFFLSCDISVPVTFRVERLEGNLPLPKSPDLENNAPTDNRTTELFVECALYIDGAPFGLPMRTRLESLGPSYCWNELITLTTKYRDLTAQSQLTFTVWDLSHGEGLIGGATILLFNNKKQLKTGKQKLRLWAGKEADGTFPTSTPGKVPRHERGELERLEKLVNKYERGQIQRVDWLDRLTFKTMERIKERESLKNGSSHMYLVVDFCSFEHRVVFQESGANFLFPSPIASTNDIVVVWDPEVGKINPSEHKQLKLARSLTRGVIDRDLKPSSNERKSIQRILKYPPTRTLSGDERQLLWKFRFSLMSEKRALTKFLRCVEWSDVQEAKQALELMGKWEMIDVCDALELLSPVFESEEVRAYAVSVLERADDEELQCYLLQLVQALRFERSAKSRLSHFLIQCALRNIELASFLRWYVAVELYDPAYAKRFYCTYEILEENMMKIAAGVNGEEDGFKQWQSLVRQTELTAQLCSITREVSNVRGNTQKKIEKLRQLLSGLLSELTYFDEPIRSPLAPGVLITGIVPSESSIFKSALHPLRLTFRAANGGTCKIIFKKGDDIRQDQLVVQMVSLMDRLLKLENLDLHLTPYKVLATGQDEGMLEFIPSRSLAQILSENRSIISYLQKFHPDDHGPFGITATCLETFIKSCAGYSVITYILGIGDRHLDNLLLRNDGGLFHVDFGFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYHILRKSSNLILNLFYLMAGSNIPDIASDPEKGILKLQEKFRLDLDDEASIHFFQDLINESVSALFPQMVETIHRWAQYWR
What is the function of this protein?
Associated with membrane proliferation.
What are the official names of this protein?
Phosphatidylinositol 3-kinase, nodule isoform, PI3-kinase, PI3K, PtdIns-3-kinase, SPI3K-1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
Protein: COX2_ZELHI
Sequence: MAYPLQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDSYMVPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKHFENWSASMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL27_STAA3
Sequence: MLKLNLQFFASKKGVSSTKNGRDSESKRLGAKRADGQFVTGGSILYRQRGTKIYPGENVGRGGDDTLFAKIDGVVKFERKGRDKKQVSVYAVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: ITIH3_RAT
Sequence: MVTLWWPCLVLALLSGLETSGFPRSPLRLLGKRSLPEGVVDGIEIYSTKISCKVTSRFAHNVVTTRAVNRADKAKEVSFDVELPKTAFITNFTLTIDGVTYPGSVKEKEVAQKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVIFELTYEELLKRNKGKYEMYLKVQPKQLVRHFEIDAHIFEPQGISMLDADASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTIVYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNIAFVIDVSGSMSGRKIQQTREALLKILDDMKEEDYLNFILFSTGVTTWKDHLVKATPANLEEARAFVKNIRDRSMTNINDGLLRGIEMLNKAREDHLVPERSTSILVMLTDGDANTGESRPEKIQENVRNAIRGKFPLYNLGFGNNLNYNFLESLALENHGFARRIYEDSDASLQLQGFYEEVANPLLTNVELEYPENAILDLTRNSYPHFYDGSEIVVAGRLVDRNVDNFKADVKGHGALNDLTFTEEVDMKEMDAALKEQGYIFGDYIERLWAYLTIEQLLEKRKNARGDEKENITAEALELSLKYHFVTPLTSMVVTKPEDNEDQTAIADKPGEEAISASTAYLTSQQSSHSPYYYVDGDPHFIIQVPGKNDTICFNIDEKPGTVLSLIQDPVTGIAVTGQIIGEKGNNASSRTGKTYFGKLGIANAWMDFRIEVTTEKIILGNGDALSTFSWLDTVTVTQTGLSVTINRKKNMVVSFEDGISFVIVLHQVWKKHPVHQDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVFDVRPGSDPMKPDATMVVKSHRLTVTRGSQKDYRKDASVGTKVVCWFVHNNGEGFIDGVHTDYIVPSLF
What is the function of this protein?
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
What are the official names of this protein?
Inter-alpha-trypsin inhibitor heavy chain H3, ITI heavy chain H3, ITI-HC3, Inter-alpha-inhibitor heavy chain 3.
What is the protein family that this protein belongs to?
Belongs to the ITIH family.
What are the subcellular locations of this protein?
Secreted.
Protein: VPB25_MYCTU
Sequence: MRTTVSISDELLATAKRRARERGQSLGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNTVLSEVLDEGLELNSRK
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Upon expression in M. smegmatis neutralizes the effect of cognate toxin VapC25.
What are the official names of this protein?
Antitoxin VapB25.
Protein: RPIA_FRATW
Sequence: MFFNKKNNQDELKKLAATEAAKSITTEITLGVGTGSTVGFLIEELVNYRDKIKTVVSSSEDSTRKLKALGFDVVDLNYAGEIDLYIDGADECNNHKELIKGGGAALTREKICVAAAKKFICIIDESKKVNTLGNFPLPIEVIPMARSYIARQIVKLGGQPVYREQTITDNGNVILDVYNLKIDNPLKLETELNQITGVVTNGIFALKPADTVIMATKDSNIVVL
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: MTRA1_METTH
Sequence: MVEKKSPAEGWPVVNGDYIVGDPESPVAATTLASHIEDVPVEAGAAIAGPCKTENLGIEKMIANLISNPNIRFLILCGSEVQGHITGQSIEALHQNGVDPDKRNIIGATGAIPYIENIPDEGIERFQKQLEIVNLIDVEDADAIKAKVKECIEKDPGAFEEEAMVIKVEEGGEEEEGEEVKPVAPETALIEARMRNIQTQVKMIGSTNRMFAGMYSGKVQGIMIGLAFTLTLGILLLV
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit A 1, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A 1.
What is the protein family that this protein belongs to?
Belongs to the MtrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL11_STRGC
Sequence: MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNARTADQAGMIIPVVISVYEDKSFTFVTKTPPAAVLLKKAAGVEKGSGTPNKTKVATVTRAQVQQIAETKMPDLNAANIESAMRMIEGTARSMGFTVTD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: NUOI_MYCVP
Sequence: MPKFLDAVAGFGVTFGSMFKKPVTEEYPEKPGPVAKRYHGRHQLNRYPDGLEKCIGCELCAWACPADAIFVEGADNTESERYSPGERYGRVYQINYLRCIGCGLCIEACPTRALTMTNDYEMADDNRSDLIYGKDKLLAPLEPGMEAPPHAMAPDSTDDDYYLGNIKPAARDAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NUOI_COXBR
Sequence: MRRLKQIIKSFTLWELLKGLSLTLRYFYRKKVTIHYPDEEVPSSFRFRGMLALRRYPNGEERCIACKLCEAVCPACAITIEAGPREADGSRRTTLYDIDAFKCINCGFCEEACPVDAIVLTPEMHYSIKDRGENILTKEKLLMIGDRYEEQIARDRAKDKKYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y379_MYCSK
Sequence: MRHDNDSWDITTSVGSTALFVAASRALEARKPDPLAVDPYAEVFCRAAGGDWAGLFDAGADPKPDHVLFSEFGEQFVNFQGARTRYFDAYFAAASDAGVRQVVLLAAGLDSRAYRLPWPDGTVVYELDQPRVLEFKREVLAERGEQPVAQRREVAVDLRDDWCAALTAAGFDPARPSAWLAEGLLMYLPATAQEALFSGIDALSAPRSWAAVEESVPMPAEVFAYKREEERAAGEEGTFFTLVYNERHAPAERWFGERGWAAEPTSLADYLTRVGRPAPVDDPEFGAMISAIRLVTATKG
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mkms_0379.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: DXS_CHLPN
Sequence: MTSSSCPLLDLILSPADLKKLSISQLPGLAEEIRYRIISVLSQTGGHLSSNLGIVELTIALHYVFSSPKDKFIFDVGHQTYPHKLLTGRNNEGFDHIRNDNGLSGFTNPTESDHDLFFSGHAGTALSLALGMAQTTPLESRTHVIPILGDAAFSCGLTLEALNNISTDLSKFVVILNDNNMSISKNVGAMSRIFSRWLHHPATNKLTKQVEKWLAKIPRYGDSLAKHSRRLSQCVKNLFCPTPLFEQFGLAYVGPIDGHNVKKLIPILQSVRNLPFPILVHVCTTKGKGLDQAQNNPAKYHGVRANFNKRESAKHLPAIKPKPSFPDIFGQTLCELGEVSSRLHVVTPAMSIGSRLEGFKQKFPERFFDVGIAEGHAVTFSAGIAKAGNPVICSIYSTFLHRALDNVFHDVCMQDLPVIFAIDRAGLAYGDGRSHHGIYDMSFLRAMPQMIICQPRSQVVFQQLLYSSLHWSSPSAIRYPNIPAPHGDPLTGDPNFLRSPGNAETLSQGEDVLIIALGTLCFTALSIKHQLLAYGISATVVDPIFIKPFDNDLFSLLLMSHSKVITIEEHSIRGGLASEFNNFVATFNFKVDILNFAIPDTFLSHGSKEALTKSIGLDESSMTNRILTHFNFRSKKQTVGDVRV
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: BDS1_ANEVI
Sequence: MNKALFLCLVVLCAAVVFAAEDLQKAKHAPFKRAAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
What is the function of this protein?
Acts as a gating modifier on both Kv and Nav ion channels, and also acts on blood pressure (By similarity).  Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3. 1/KCNC1, Kv3. 2/KCNC2 and Kv3. 4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1. 7/SCN9A (By similarity).  Inhibits all Kv3. 1, Kv3. 2 and Kv3. 4 by about 50% when tested at a voltage of +40 mV (45%, 48% and 56%, respectively) (By similarity).  May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (By similarity).  On sodium channels, tests have been done on human Nav1. 7/SCN9A (expressed in HEK293 cells) (EC(50)=3 nM) and rat SCG neurons that mostly carry Nav1. 7 channels (EC(50)=300 nM) (By similarity).  This toxin also reduces blood pressure (By similarity).
What are the official names of this protein?
Kappa-actitoxin-Avd4a, Kappa-AITX-Avd4a, Antihypertensive protein BDS-1, Blood depressing substance 1, BDS-1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: NADA_THET2
Sequence: MGRMRGEALAQEVLRLKRERNAVILAHSYQLPEVQEVADFVGDSLGLAREAQRTRAEVIVFCGVHFMAETAAILNPEKTVLLPDLEAGCSLADSIRPEDVLAWKAKHPDGIVVAYVNTKAEVKALADVCVTSANAVEVVSRLPQDRPIYFVPDMFLGAHVARATGRRLDLFPGECHVHAGIREEHLKALLEAHPGAEFLIHPECGCGSGCLYLKPDAKMLSTEGMVRYAKGAEAREFVVATEVGILHRLKKEAPEKAFFPVKPDAVCEYMKRITLEKVYLSLKEMRHVVRVPEEVAGRARRALEAMVAVG
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLME_XANOP
Sequence: MPSRSKSSQRWLKEHFADPYVKKARAEGMRSRAAYKLEELLQRDRLLKPGMVVVDLGAAPGGWSQQVRKSMGDSGRVVALDILDMPALAGVEFLHGDFREQAVLSQFEAMLGDVPVDLVLSDMAPNKSGMDAVDQPRMMHLAELAMEFADAHLKPGGAFLIKLFQGVGSDDYIRELRRRYEKVTIRKPAASRKRSPEVYALGQGKRVQIK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDRP_STAA9
Sequence: MEKIKIIVASDSIGETAELVARAGISQFNPKQCKNELLRYPYIESFEDVDEVIQVAKDTNAIIVYTLIKPEMKQYMSEKVAEFQLKSVDIMGPLMDLLSASVEEKPYNEPGIVHRLDDAYFKKIDAIEFAVKYDDGKDPKGLPKADIVLLGISRTSKTPLSQYLAHKSYKVMNVPIVPEVTPPDGLYDIDPKKCIALKISEEKLNRIRKERLKQLGLGDTARYATEARIQEELNYFEEIVSEIGCPVIDVSQKAIEETANDIIHYIEQNKSK
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: GLO2_YERPB
Sequence: MNLISIPAFQDNYIWLLANRQKHCVIVDPGESAPVLATLAQGQYVPQAILLTHHHNDHVGGVADLRHHFPDIPVYGPQETAKKGATVIVNDGDSLTIAGQNYTIIAVPGHTLGHIAYYSSPYLFCGDTLFSAGCGRLLEGTPEQMYASIQRLAQLPDETLICCAHEYTLSNLKFAHAILPADQDIATYQQQIEQLRSKNLPSLPVKLQFERKINVFLRCNDIDLQRKIGITSPPDSLVSVFCELRSRKDSF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.