Protein: ATR_ARATH
Sequence: MAKDDNNLSSLVHELRERVAASASTPANNLRHSSGDEDALEIRFRAVIPNLLNTYVVPSLGNGREVTAVLKLVGHTARNIPGVFYHGTPSAILPVIARIIPFFAEPEFVPGHGVLLETVGSLLMLLRSNSRKAYRIFFHDALQAIQDMQPIASLHSIEPEVCESHIPFRCFCMSFSGIGGDLPDANKPRDGDGLVLNLLGANRWQPFATCILKLICKCLTEGTLYVQGLIHTSFFKAACSLVCCGGADVQMACFEFATLVGSILTFNILPHVALIQSIILLLSADEGLPVYRNTIYDSTIGRFLTAVYSSCSDAAVKLTAESLVLVLSHALQRTKSEELKASLCSAYVRIVKSCPPCIWKIHCLLELLHLPEPCFQLIECFKAVLIVLGPGCVRVETTKCGSHTSATSDRPVQGINAGKKRHIEDESTYKRKRQKVGDDIRRGVYFAPEFADETDGKDAASLREMLISTVESLKPPPAGPSLSQTESSIVALSMLTNAFCFCPWTDMTHRLFNQMYAWIPWIAGQVEETNPIMFDISIYLEGIHNLLLVGVDPQYEYTSKGNDLVAIQFLLKLPWTHYMLFKTPSSLVKSKCLSVGIWTKLGLQDGSDFDIFSWSLSDDFEQVQAVAAISMPLKVLFSGLGALLHMFPKLEHLLEEKELMIKKAIPQSLGFLSCLYGSSTTDSEKTACHLLLHEDLKKDETLNSLLQGFRCSKCDKFIEREDEKHFRIIETPEMVKLKMDHHRDYFNLQSLYFNLLYDESSEETQLACVEVIRRILGHTSPDILVRTRSQWIRCLQYLLVHVNTDVREAFCAQIGIFVQHPIVSCLFLSEDATEKSCERNFFNLIEHSLAAAKDLLVIQTLLETTAEVMVAVDVTSELFLICLFLLIDQLDHPNLIVRINASKLINRSCYIHVKGGFATLLSTASHIQNELFDNLSVRLTSRPNVVREFAEAVLGVETEELVRKMVPAVLPKLLVYWQENAQAANTLNELAKLIDTDVVPLIVNWLPRVLAFALNQEEDKNLLSVLQLYHSQIGSDNQEIFAAALPALLDELVCFVDIADTPETDRRLQRLPDAIKKISKVLTNAEDLPGFLQNHFVGLLNSIDRKMLHADDIFLQKQALKRIKLLIEMMGHYLSTYVPKLMVLLMHAIEKDALQSEGLLVLHFFTRKLADVSPSSIKYVISQIFAALIPFLEKEKEGPHVYLDEVVKILEELVLKNRDIVKEHICEFPLLPSIPSLGELNNAIQEARGLMSLKDQLRDIVNGMKHENLNVRYMVACELSKLLYNRNEDVAALIAGELVSDMEILSSLITYLLQGCAEESRTTVGQRLKLVCADCLGAIGAIDPAKVRVASCSRFKIQCSDDDLIFELIHKHLARAFRAAQDTIIQDSAALAIQELLKIAGCEPSLAGNVVVLTPQEHVQVNVSGSRRCGGNNEVKDRGQKLWDRFSNYVKELIAPCLTSRFQLPNVSDPGSAGPIYRPSMSFRRWLSYWIRKLTAFATGSRVSIFAACRGIVRHDMQTATYLLPYLVLDVVCHGTEAARLSISEEILSVLDAAASENSGVTINSFGVGQSEVCVQAVFTLLDNLGQWVDDVKQGVALSSSLQSSGGRQVAPKSKDQVSNSTTEQDHLLVQCKYVLELLLAIPKVTLARASFRCQAYARSLMYLESHVRGKSGSLNPAAEKTGIFENADVSSLMGIYSCLDEPDGLSGFASLSKSLNLQDQLLINKKSGNWADVFTACEQALQMEPTSVQRHSDVLNCLLNMCHHQTMVTHVDGLISRVPEYKKTWCTQGVQAAWRLGKWDLMDEYLDGADAEGLLFSSSDSNASFDRDVAKILHAMMKKDQYSVAEGIAISKQALIAPLAAAGMDSYTRAYPFVVKLHLLRELEDFQAVLNGDSYLEKSFSTSDQVFSKAVDNWENRLRFTQSSLWTREPLLAFRRLVFGASGLGAQVGNCWLQYAKLCRLAGHYETAHRAILEAQASGAPNVHMEKAKLLWITKRSDSAIIELQQSLLNMPEGVVDSTVISSINSLLMAPPNPEPTVRNTQSFKEKKDVAKTLLLYSKWIHHSGQKQKKDVLNLYTQVKELLPWEKGYFHLAKYYDELYVDARKCQQESSVFSSAGSKKGSVSSNLSTEKAGWDYLFKGMYFYAKALHSGHKNLFQALPRLLTLWFDFGTIYKTSGSAGNKELKSTHMKIMSLMRGCLKDLPTYQWLTVLPQLVSRICHQNADTVLMVKNIITSVLHQFPQQGLWIMAAVSKSTVPARREAAAEIIQGARKGFNQSDRGHNLFIQFASLTDHFIKLCFHGGQPRSKVINIATEFSALKRMMPLDIIMPIQQSLTISLPAFHMNNNERHSASVFSGSDLPTISGIADEAEILSSLQRPKKIILLGNDGIEYPFLCKPKDDLRKDARMMEFTAMINRLLSKYPESRRRKLYIRTFAVAPLTEDCGLVEWVPHTRGLRHILQDIYISCGKFDRQKTNPQIKRIYDQCAVKKEYEMLKTKILPMFPPVFHKWFLTTFSEPAAWFRSRVAYAHTTAVWSMVGHIVGLGDRHGENILFDSTSGDCVHVDFSCLFDKGLQLEKPELVPFRLTQNMIDGLGITGYEGIFMRVCEITLTVLRTHRETLMSILETFIHDPLVEWTKSHKSSGVEVQNPHAQRAISSIEARLQGVVVGVPLPVEGQARRLIADAVSLENLGKMYIWWMPWF
What is the function of this protein?
Probable serine/threonine kinase.  Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression.  May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism.  Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks.  May also be involved in the meiosis process.  Required for the basal expression of RNR1 (ribonucleotide reductase large subunit).  Acts in concert with telomerase to maintain telomeric DNA tracts.  Not required for telomere length homeostasis.  Required for effective immune responses that involve activation of DNA damage responses (PubMed:24207055).
What are the official names of this protein?
Serine/threonine-protein kinase ATR, AtATR, Ataxia telangiectasia-mutated and Rad3-related homolog, DNA repair protein ATR, Rad3-like protein, AtRAD3.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. ATM subfamily.
What are the subcellular locations of this protein?
Nucleus.