PharMolix/UniProtQA huggingface dataset:
Protein: AFG31_MOUSE
Sequence: MLLRLVGAAGSRALAWPFSKLWRCGGCAGSGGTVWSSVRACGIALQGHLGRCSQQLALQGKLTSFSPRLYSKPPRGFEKFFKNKKNRKSASPGNSVPPKKEPKNAGPGGDGGNRGGKGDDFPWWKRMQKGEFPWDDKDFRSLAVLGAGVAAGFLYFYFRDPGKEITWKHFVQYYLARGLVDRLEVVNKQFVRVIPVPGTTSERFVWFNIGSVDTFERNLESAQWELGIEPTNQAAVVYTTESDGSFLRSLVPTLVLVSILLYAMRRGPMGTGRGGRGGGLFSVGETTAKILKNNIDVRFADVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVNGSEFLEMFVGVGPARVRDMFAMARKHAPCILFIDEIDAIGRKRGRGHLGGQSEQENTLNQMLVEMDGFNSSTNVVVLAGTNRPDILDPALTRPGRFDRQIYIGPPDIKGRSSIFKVHLRPLKLDGSLSKDALSRKLAALTPGFTGADISNVCNEAALIAARHLSPSVQERHFEQAIERVIGGLEKKTQVLQPSEKTTVAYHEAGHAVVGWFLEHADPLLKVSIIPRGKGLGYAQYLPREQFLYTREQLFDRMCMMLGGRVAEQLFFGQITTGAQDDLRKVTQSAYAQIVQFGMSEKLGQVSFDFPRQGETMVEKPYSEATAQLIDEEVRCLVRSAYNRTLELLTQCREQVEKVGRRLLEKEVLEKADMIELLGPRPFAEKSTYEEFVEGTGSLEEDTSLPEGLKDWNKGREEGGTERGLQESPV
What is the function of this protein?
Putative ATP-dependent protease.  Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form.
What are the official names of this protein?
AFG3-like protein 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GAG_HV190
Sequence: MGARASVLSGGKLDAWEKIRLRPGGKKKYRLKHLVWASRELERFALNPGLLETPEGCLQIIEQIQPAIKTGTEELKSLFNLVAVLYCVHRKIDVKDTKEALDKIEEIQNKSQQKTQQAAADKEKDNKVSQNYPIVQNAQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNAMLNTVGGHQAAMQMLKDTINEEAAEWDRVHPVHAGPIPPGQMREPRGSDIAGTTSTLQEQIAWMTGNPAIPVGDIYKRWIILGLNKIVRMYSPVSILDIKQGPKEPFRDYVDRFFKTLRAEQATQDVKNWMTETLLVQNANPDCKTILRALGQGASIEEMMTACQGVGGPSHKARVLAEAMSQVTNTNTAIMMQKGNFKGQRKFVKCFNCGKEGHIARNCRAPRKKGCWKCGREGHQMKDCTERQANFLGKIWPSSKGRPGNFLQSRPEPTAPPAESFGFGEEMTPSPKQEQLKDKEPPLASLRSLFGSDPLLQ
What is the function of this protein?
Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.
Protein: DCTS_RHOCA
Sequence: MRDTTGGPAGAEVWTVPGLLGARKLDLLALIPLVAIVALMTLVGALLFAVAQSDANRARAKLATDALWVEQTLRFQMAVDEDVLVRLALDASAGASQQALSARARLHLAANPETLGLRWYDATGRLIAAVPEGPGPAEAALVRQLLASGALPPRPVYGPVRDGRVVLAERVSASGGVVVATVSLPMMLERHLPWWIAEQYGVRISDTSGVLAERARRPIAAAAPRHGISFDPPLAGTTLEIMAYDAPDAFGNAALLAAIGALSVFAVLAMVVLHRNALRRRMAEDRLRAEMAFRRAMEESLTVGMRAKDLSGRILYVNGAFCKLVGLAAEDLVGRAQPMPYWAPDFLEETLARQRQLIEGQPVPQAFETRFRRSDGSEIEVQVFEAPLIDAGGRHRGWMGSVIDITQAKQAARLARAQDESLARTGRLVTLGEMASTLAHELNQPLAAIASYAAGGLNLFDQPEPNLTMLRQAFEKMGAQARRAGLVIRRVQDFVKKRTPQLAALDLSEVLAEALSITAPVAREHRVKLASLIEGRIPGVQADRILIEQVLVNLIRNGVEAMAEGPRTGDDLTVRLARAGAAVTIEVMDRGPGISDAVAASLFDPFTSTKSEGMGMGLNICRSIVEMHHGSLSHGPRAGGGTVFTVTLPVPQEGAPA
What is the function of this protein?
Member of the two-component regulatory system DctS/DctR involved in the transport of C4-dicarboxylates.  DctS functions as a membrane-associated protein kinase that phosphorylates DctR in response to environmental signals.
What are the official names of this protein?
C4-dicarboxylate transport sensor protein DctS.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF4A1_MOUSE
Sequence: MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
What are the official names of this protein?
Eukaryotic initiation factor 4A-I, eIF-4A-I, eIF4A-I, ATP-dependent RNA helicase eIF4A-1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: FENR_STRP6
Sequence: MKDKAYDITIIGGGPIGLFAAFYAGLRGVTVKIIESLSELGGQPAILYPEKMIYDIPAYPSLTGVELTENLIKQLSRFEDRTTICLKEEVLTFDKVKGGFSIRTNKAEHFSKAIIIACGNGAFAPRTLGLESEENFADHNLFYNVHQLDQFAGQKVVICGGGDSAVDWALALEDIAESVTVVHRRDAFRAHEHSVELLKTSTVNLLTPYVPKALKGIGNLAEKLVIQKVKEDEVLELELDSLIVSFGFSTSNKNLKNWNLDYKRSSITVSPLFQTSQEGIFAIGDAAAYNGKVDLIATGFGEAPTAVNQAINYIYPDRDNRVVHSTSLID
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: TPC3L_HUMAN
Sequence: MSRPAHRRPEYHKINKDLFVLTYGALVAQLCKDYEKDEDVNQYLDKMGYGIGTRLVEDFLARSCVGRCHSYSEIIDIIAQVAFKMYLGITPSVTCNNSSKNEFSLILEKNPLVEFVEELPAGRSSLCYCNLLCGIIRGALEMVHLAADVTFLQDRLKGDSVTEIGITFLKKRDEKKYRGKK
What is the function of this protein?
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
What are the official names of this protein?
Trafficking protein particle complex subunit 3-like protein, TRAPPC3-like protein, BET3-like protein.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. BET3 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
Protein: CRCB_CHESB
Sequence: MYHLMLVCLGGAIGAGMRHLTVTAAGRALGTAFPWGTLAVNVAGSFAMGLLVEALARKFSVSNEIRLLLAPGMLGGFTTFSAFSLDVAVLWERGAQSAALAYVLASVAGSILALFVGLWLARSIL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNMA_RUBXD
Sequence: MPERYGPRVIEHLVNPRNAGEVGGPSGVGEAGNAACGDQVRFTLRVGGDLRLQEVRYRAYGCAACIAAGSALAELAEGRSITGAAQISRGDIQEALGGPLPPGKEHGATLALDALHRAFEDYWSRQGDALLGGEGLGDGSGGRRGVVAAMSGGVDSAVTALLLKERGYEVVAVTFRLHDGEPGSRSCCSPDTVLFARETAHGLGIPHFTLNLRELFDRRVMRDFVGSYAAGRTPNPCVACNAHVKFHAAAFLADRLGLRHVATGHYARVGEGPCLERPEDGRKDQTYVLWPVPPRLLGRTIFPLGDYRKSEVRRIAEERGLAVARTPESQDICFIPDGDYRSFVRRRVRSEPGEIVDRQGRVLGRHAGVVDFTVGQRRGLGISAPTPLYVTEVRPRSRQVVVGSRRELEVRRMLVRGANWFLDPREAALVQVRYNGEPVPCELEEGAGGWEVALLEPVFGVAPGQSAVFYTRDGAKVVGGGIIARRDA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
Bifunctional protein NifU/MnmA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DJC11_DICDI
Sequence: MNKIDKDILKIFESKENEQFDEDQEKDEKKMNEVDFYSILNISRNATDDEIKIAFKKLAFTYHPDKQTNEELKKETQDIFTLITLAKDTLSDPKLRAIYDQFGLEGIEHSKAIVNKYKEVDKLLQALDRIQKENEEDKLIQSFSATGSQSISLAYHHEYRHFFFKTLKSEAQFDIKTQKYGSFEFVPSITRKKNLAWFGLETSYLYPITQNTELFLSNNYNEANEGSIQTIGLKSLLSANTYGSIHCAFFDSFQPARFGCLLTRQLSPTITAIFRGTLQKEFWQGSLTLKRIVQKRLFEITIDSSNLGGLSGSITRDIPISKKSRISFSVGGYGGGFPLYSAGQHGFTGAAIGFKRKITKVFDIDLSMHVNPSRYLYVIGLHHRYQSLEIPIPIYSDLSLSTSLLFFTLPAVTLSLLKYLVVKPLMKKKEQKKIMEKKEKYADQARKAKRKAEMDITLVKQLVENKVLKEKTKNGLIIQEAVYGKLDEKVDHSDPFSVEFPPTIDVTIPLQYLVEDSKLVLHGNNKKSDLLGFWDPRISEEKQLKVTYFFQNRLHRITVNDIDQLLIPLKSHLIQ
What are the official names of this protein?
DnaJ homolog subfamily C member 11 homolog.
What is the protein family that this protein belongs to?
Belongs to the DNAJC11 family.
Protein: Y2298_LACP7
Sequence: MQEINNTQYFRVQKQPEIVVKDVIDIVYLALTEKGYNPVNQIVGYIMSGDPTYITNHRNARSLIMKVERDEILEELMHYYIDNHLKRR
What are the official names of this protein?
UPF0297 protein Cphy_2298.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: RS15_BURL3
Sequence: MSVADIKKSEVVAQFARGTNDTGSPEVQVALLTARIVELTGHFKTHAKDHHSRRGLLRMVSRRRKLLDYLKGKDADRYRALIEKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: YQGF_SODGM
Sequence: MAAAGSIMAFDFGTRSIGVAIGQRVTCTARPLTAFKARDGVPDWQQIEKLLKEWRPETVVVGLPLNMDGSEQPLTARVRKFANRMHGRFGVQVVLHDERLSTVEARAGLFERGGYRALEKGKVDAGSAVIILESWLEQFPE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPPH_BORPE
Sequence: MLDREGYRPNVGIILVNGKNEVFWGKRIREHAWQFPQGGIKYGESPVQAMYRELHEEVGLKPEHVRILGRTRDWLRYNVPDHFVRREWRGHYKGQKQIWFLLRLVGRDSDVCLRATQHPEFDAWRWSQYWVPLDAVIEFKRDVYTQALNELAVILFRRHHETRYLRQRVHGPRSTDSPSSETDGHAHIAG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: SECA_LACLA
Sequence: MPNIIRKLVENDKKELKKLNRMALQVESFADEMEHLTDEQLKAKTPELKERIAKGESLDDLLYEAFAVCREAARRVLGLYPFHVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNALSGKGVHVVTVNEYLATRDMTEMGELYSWLGLTVGLNLNSKSPEEKREAYNCDITYSTSAELGFDYLRDNMVTRAEDMVQKPLNYALVDEVDSILVDEARTPLIISGQAESSSALYYRADQFTKTLKGQNLNVATSEYEEGDDYKIDLQSKTISLTEEGIDKAEKFFQIENLYDMENVALTHFVDNALRANFIMLHDIDYMVDENQEVLIIDQFTGRTMPGRRYSDGLHQAIEAKEAVPIQDESKTMASITIQNYFRMYKKLSGMTGTAKTEEEEFREIYNIQITPIPTNRPVQRLDHPDLLYPTLEAKFKAVIDDIKRRHAEGQPILIGTVAVETSELISKKLVEAKIPHEVLNAKNHFREAQIIMNAGQQGAVTIATNMAGRGTDIKLGPGVIDHVDPEFRGLAVIGTERHESRRIDNQLRGRSGRQGDPGVSQFYLSLEDELMKRFGSERVSAFLDRMRISGEDAVIKSGLITRQIESSQKRVEGNNYDSRKQVLQYDDVIREQREVIYAQRQEVILATEDMTPVLMGMFKRTIDRQVDGHELAGSLKDEENVKNLLQTLHNTMLPEDGIELSELTGLSVQAMKDLIFDKVKARYASQMEKLSDPERQLEFQRAVILRVVDNNWSEHIDALDQMRQSVGLRGYAQNNPIVEYQEESYKMYNNMIGAIEFEVTRLMMKAQIQPQTAIRQEAPRMTTTASQENITNVDTEHSVSEEISFENVGRNDLCPCGSGKKFKNCHGRTHIA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: MNTR_ECOL6
Sequence: MSRRAGTPTAKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIREVGEARQVDMAARLGVSQPTVAKMLKRLATMGLIEMIPWRGVFLTAEGEKLAQESRERHQIVENFLLVLGVSPEIARRDAEGMEHHVSEETLDAFRLFTQKHGAK
What is the function of this protein?
In the presence of manganese, represses expression of mntH and mntS.  Up-regulates expression of mntP (By similarity).
What are the official names of this protein?
Transcriptional regulator MntR, Manganese transport regulator.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUAK_ECOLI
Sequence: MVRRLRFSGPKTSIICSPMTSLKTSIKTITYLSDIGCLEIQGASLAGSGSGGEHAAVLYSLIGTCRLNNVELEKWLCYGIEHIQDWSANLVRDL
What are the official names of this protein?
Uncharacterized protein YuaK.
Protein: MQO_MICLC
Sequence: MPTTSSTATHDVVLIGGGIMSATLGVLLQKLEPTWSIALYENLDQAGLESSDPWNNAGTGHAALCELNYSPMDKNGRVDVTKALGINEQFWITRQFWSSLVVDGTLKDPKSFINPLPHMSFVWGDDHADYLRARYEAMSAQPVFAGMEHSEDPEQIRAWAPLLIEGRESGQRLAASRHTGGTDVDFGSLTRQLVTAMAGAGAEVRFGHKVTGLTRGTDGRWEVKVKNKAAGSEVVDRARFVFVGAGGGALPLLQKSGIPEIKGFGGFPVSGQFLRCTDESVVNQHMAKVYGQAAVGAPPMSVPHLDTRFVNGKRSLLFGPYAGFSTNFLKTGSYLDLPLSVRPHNLTTMLDVAKDNVDLTKYLVTEVLKSRDKKIDALHEFYPEADGGEWELITAGQRVQVMKRKGRFGGVLQFGTEVVTHADGSLGGLLGASPGASTAAPIMVKLLERCFPAKTAGWDGTLKELIPSLGHTLNDDPALLDEVRTVTDAALKLA
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: YCF60_NEOYE
Sequence: MIRLFTFAIITVFLIVISRLALQRAYKYIKLNKKINNTESKTRLSIRLVSTVPYYLPLFEGLQNFGQYVLPDYPVAAIPLYKKIILPMLIFYMNHAILGLVTFFALYYVLVRNKSPIPVHQLVRFNSMQSILLFLVGSLFGAVFRAFPIEFRISFLGLMVCNMMFWFVLSTITYSIVKAVQGKYSNIPVISEAVRIQISGYST
What are the official names of this protein?
Tic20 family protein Ycf60.
What is the protein family that this protein belongs to?
Belongs to the Tic20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: PUR4_SALTI
Sequence: MMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFADLNAPLNDSEQAQLTRLLQYGPALSSHTLAGKLLLVTPRPGTISPWSSKATDIAHNCGLQQIDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVFSSLTDAEKLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYLQEAFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKMIKNTFETTPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHILMKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGPAMNIGLGGGAASSMASGQSDADLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLSNAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPKMTRDVQTLKAKGDALNRADITIADAVNRVLHLPTVAEKTFLVTIGDRTVTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLDFAASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAVKAVGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVEDVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRDVAQLKGFYDAMQVLVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDIAALGDDHLAALFNEELGGVIQVRAEDRDAVETLLAQYGLADCVHYLGQALAGDRFVITANDRTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAKANDADPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMAAAFHRAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWAKSILFNHRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSELWPRFVRNHSDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHLAALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIMMPHPERVFRTVANSWHPENWGEDSPWMRIFRNARKQLG
What is the function of this protein?
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AN32B_BOVIN
Sequence: MDMKRRIHLELRNRTPAAVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSDNRICGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDREAPDSDAEVDGVDEEEDDEEGEDEDKEEDEDGEEEEFDDEEDDDEDEDVEGEEDEDEVSGEEEEFGHDGEVDEDDEDEDEDEDEDEEEEESGKGEKRKRETDDEGEDD
What is the function of this protein?
Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription.  Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle.  As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis.  Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes.  Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (By similarity).  Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity).
What are the official names of this protein?
Acidic leucine-rich nuclear phosphoprotein 32 family member B.
What is the protein family that this protein belongs to?
Belongs to the ANP32 family.
What are the subcellular locations of this protein?
Nucleus. Note=Accumulates in the nuclei at the S phase.
Protein: U7A15_MALDO
Sequence: MKRPAQLVFVPAPGIGHIVSTVEMAKQLAARDDQLFITVLVMKLPYAQPFTNTDSSISHRINFVNLPEAQPDKQDIVPNPGSFFRMFVENHKSHVRDAVINVLPESDQSESTSKPRLAGFVLDMFSASLIDVANEFKVPSYLFFTSNASALALMSHFQSLRDEGGIDITELTSSTAELAVPSFINPYPAAVLPGSLLDMESTKSTLNHVSKYKQTKGILVNTFMELESHALHYLDSGDKIPPVYPVGPLLNLKSSDEDKASDILRWLDDQPPFSVVFLCFGSMGSFGEAQVKEIACALEHSGHRFLWSLRRPPPQGKRAMPSDYEDLKTVLPEGFLDRTATVGKVIGWAPQAAILGHPATGGFVSHCGWNSTLESLWNGVPIAAWPLYAEQNLNAFQLVVELGLAVEIKMDYRRDSDVVVSAEDIERGIRRVMELDSDVRKRVKEMSEKSKKALVDGGSSYSSLGRFIDKI
What is the function of this protein?
Glycosyltransferase that possesses chalcone and flavonol 2'-O-glycosyltransferase activity.  Converts phloretin to phlorizin (phloretin 2'-O-glucoside), a potent antioxidant.  Possesses glycosyltransferase activity toward, naringenin, naringenin chalcone, eriodictyol, eriodictyol chalcone, apigenin, luteolin, kaempferol, quercetin, isoliquiritigenin, butein and caffeic acid.  Can convert phloretin to phloretin 4'-O-glucoside and phloretin 4-O-glucoside.
What are the official names of this protein?
UDP-glycosyltransferase 71A15, UDP-glucose:chalcone 2'-O-glucosyltransferase, UDP-glucose:flavonol 2'-O-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: PQQC_KLEPN
Sequence: MLITDTLSPQAFEEALRAKGAFYHIHHPYHIAMHNGDATRKQIQGWVANRFYYQTTIPLKDAAIMANCPDAQTRRKWVQRILDHDGSHGEDGGIEAWLRLGEAVGLSRDDLLSERHVLPGVRFAVDAYLNFARRACWQEAACSSLTELFAPQIHQSRLDSWPQHYPWIKEEGYFYFRSRLSQANRDVEHGLALAKAYCDSAEKQNRMLEILQFKLDILWSMLDAMTMAYALQRPPYHTVTDKAAWHTTRLV
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.
Protein: VATD_HALS3
Sequence: MAQDIKPTRKNLMEIEDRIDLSERGHDTLEQKRDGLIMEFMDILDQSQDVRSGLEGDYETAQQKINMARAMEGDVAVSGAAAALEEYPEITVESMNIMGVVVPQIESTKVKKSFDKRGYGILGTSARIDEAADAYEELLESIVLAAEVETAMKKMLTEIETTKRRVNALEFKLLPELHEGKEYIDQKLEEKEREEMFRMKKVKDKKEAQEEAADEAAAAESTGA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: VE2_HPV38
Sequence: METLSARFTVLQEKLMDIYESGVEDLDTQIQHWQLLRQEQIIYHYARRHGVTRLGYQPVPSLASSEAKAKDAISMVLLLESLKKSKYADEQWTLAQTSLEAVRSPPADCFKKGPKNIEVVFDGDPENLMSYTVWTYIYYLTDEDIWEKVEGHVDYTGAYYYEGKLKVYYLKFENDAKRYGVTGLWEVHVNKDTVFTPVTSSTPPVGDSTDSASRAALPEPSTSVSPERPPSQTARRYGRKASSPSTTSRRQRKGQRETTGTQRRRKSRSRSRSTNRGGRDTRRSSSRGSSVSPTRGRRRGGGDSRRRGPVTRSRSRSLSRASSAGGGISPDKVGTAVRSVGRQSGGRLTRLLADAADPPVILLRGDANTLKCYRYRFRKKHAGGFRFVSTTWSWIGDASNDRIGRSRMLLAFYSESQREKFIQTMKLPTGVEWSLGQFDDL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: TVB73_HUMAN
Sequence: MGTRLLCWAALCLLGADHTGAGVSQTPSNKVTEKGKDVELRCDPISGHTALYWYRQSLGQGPEFLIYFQGTGAADDSGLPKDRFFAVRPEGSVSTLKIQRTEQGDSAAYLRASSL
What is the function of this protein?
Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447).  Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
Probable non-functional T cell receptor beta variable 7-3.
What are the subcellular locations of this protein?
Cell membrane.