PharMolix/UniProtQA huggingface dataset:
Protein: GPAT1_HUMAN
Sequence: MDESALTLGTIDVSYLPHSSEYSVGRCKHTSEEWGECGFRPTIFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDVHKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKRILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSALLSLEQALLPAILPSRPSDAADEGRDTSINESRNATDESLRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGLGGPTSTPPNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAEHDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLITRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVVL
What is the function of this protein?
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 1, mitochondrial, GPAT-1.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: CCN3_HUMAN
Sequence: MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELELKTTRGKM
What is the function of this protein?
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162).  Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078).  Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287).  Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162).  Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355).  Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis.  In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522).  Also plays a role in cutaneous wound healing acting as integrin receptor ligand.  Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5.  Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078).  Involved in bone regeneration as a negative regulator (By similarity).  Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891).  Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity).  Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504).  Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity).  Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression.  Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).
What are the official names of this protein?
CCN family member 3, Cellular communication network factor 3, Insulin-like growth factor-binding protein 9, IBP-9, IGF-binding protein 9, IGFBP-9, Nephro blastoma-overexpressed gene protein homolog, Protein NOV homolog, NovH.
What is the protein family that this protein belongs to?
Belongs to the CCN family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cell junction, gap junction. Note=Localizes at the gap junction in presence of GJA1.
Protein: YL58_CAEEL
Sequence: MNKKSVGQPPEGLHETKSLASALPEKNAEQRPKYVQIVALPSEIKSRELPIAPDNVVYFNGPTHYLSALYPCTVVVDGNEYNSVEHYYQACKLYVLTGEQSAAQLKASETPIEVKKATKNILKEAKIPAKKISAWKDKDSIAVLKHVIYHKFNQNDELKVKLLDTGDKILIQTYIGDTYFAAGANAKYTSTWVDRHVNQSLKYPENVVVDNVQYLPLVANGKNVLGWILMQVRDELRMRSSA
What are the official names of this protein?
Uncharacterized protein F44E2.8.
Protein: PAPA1_CARPA
Sequence: MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
What is the function of this protein?
Cysteine proteinase with a high level of diversity in substrate specificity, an amino acid bearing a large hydrophobic side chain at the P2 position is preferred.
What are the official names of this protein?
Papain, Papaya proteinase I, PPI.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: TNNC1_PIG
Sequence: MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLEELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
What is the function of this protein?
Troponin is the central regulatory protein of striated muscle contraction.  Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.  The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
What are the official names of this protein?
Troponin C, slow skeletal and cardiac muscles, TN-C.
What is the protein family that this protein belongs to?
Belongs to the troponin C family.
Protein: UBF1_HUMAN
Sequence: MNGEADCPTDLEMAAPKGQDRWSQEDMLTLLECMKNNLPSNDSSKFKTTESHMDWEKVAFKDFSGDMCKLKWVEISNEVRKFRTLTELILDAQEHVKNPYKGKKLKKHPDFPKKPLTPYFRFFMEKRAKYAKLHPEMSNLDLTKILSKKYKELPEKKKMKYIQDFQREKQEFERNLARFREDHPDLIQNAKKSDIPEKPKTPQQLWYTHEKKVYLKVRPDATTKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQKHPELNISEEGITKSTLTKAERQLKDKFDGRPTKPPPNSYSLYCAELMANMKDVPSTERMVLCSQQWKLLSQKEKDAYHKKCDQKKKDYEVELLRFLESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPVSAMFIFSEEKRRQLQEERPELSESELTRLLARMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLARFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLAEEQQKQYKVHLDLWVKSLSPQDRAAYKEYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSSGDSSDSDSN
What is the function of this protein?
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex.  It binds specifically to the upstream control element.
What are the official names of this protein?
Nucleolar transcription factor 1, Autoantigen NOR-90, Upstream-binding factor 1, UBF-1.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ANIS5_ANISI
Sequence: MKTLIVAALFCTIGMALADDTPPPPPFLAGAPQDVVKAFFELLKKDETKTDPEIEKDLDAWVDTLGGDYKAKFETFKKEMKAKEAELAKAHEEAVAKMTPEAKKADAELSKIAEDDSLNGIQKAQKIQAIYKTLPQSVKDELEKGIGPAVPQ
What are the official names of this protein?
SXP/RAL-2 family protein Ani s 5.
What is the protein family that this protein belongs to?
Belongs to the SXP/RAL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NS2A_CVMJH
Sequence: MAARMAFADKPNHFINFPLAQFSGFMGKYLKLQSQLVEMGLDCKLQKVPHVSITLLDIKADQYKQVEFAIQEIIDDLAAYEGDIVFDNPHMLGRCLVLDVKGFEELHEDIVEILRRRGCTADQSRQWIPHCTVAQFDEEKEIKEMQFYFKLPFYLKHNNLLTDARLELVKIGSSKVGGFYCSELSIWCGERLCYKPPTPKFSDIFGYCCIDKIRGDLEIGDLPPDDEEAWAELSYHYQRNTYFFRHVHDNSIYFRTVCRMKGCMC
What is the function of this protein?
Not essential for virus replication in transformed murine cells.
What are the official names of this protein?
Non-structural protein 2a, ns2a, 30 kDa accessory protein, 30 kDa non-structural protein, ns2, p30.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses ns2a protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: AROD_DEHMB
Sequence: MKIPPICCVITQLPQAETLKKSEGAAFYELRLDLLGENWRETAVLLNKPFMATCRRSAEGGSFKGNEAERINRLEKAASAGAFMLDIEYSTPNLEEVLGRLRPQAKCLLSHHNFTDTPSAAKLKTLLKDMLTHQADIYKVITTATSINDNINLLNLTKEIPDKKIVAFAMGEPGILSRILCPLAGSPFTYASLNDGNKSASGQMTLAQMIEIYRSVNYANHT
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: GT14_ORYSJ
Sequence: MAMRLSSAAVALALLLAATALEDVARGQDTERIEGSAGDVLEDDPVGRLKVYVYELPTKYNKKMVAKDSRCLSHMFAAEIFMHRFLLSSAIRTLNPEEADWFYTPVYTTCDLTPWGHPLPFKSPRIMRSAIQFISSHWPYWNRTDGADHFFVVPHDFGACFHYQEEKAIERGILPLLRRATLVQTFGQKDHVCLKEGSITIPPYAPPQKMKTHLVPPETPRSIFVYFRGLFYDTANDPEGGYYARGARASVWENFKNNPLFDISTDHPPTYYEDMQRSIFCLCPLGWAPWSPRLVEAVVFGCIPVIIADDIVLPFADAIPWDEIGVFVAEDDVPKLDTILTSIPMDVILRKQRLLANPSMKQAMLFPQPAQPGDAFHQILNGLGRKLPHPKSVYLDPGQKVLNWTQGPVGDLKPW
What is the function of this protein?
Involved in the synthesis of glucuronoxylan hemicellulose in secondary cell walls.
What are the official names of this protein?
Probable glucuronosyltransferase Os01g0926600.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 47 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: SLAF6_MOUSE
Sequence: MAVSRAPAPDSACQRMVWLFPLVFCLGSGSEVSQSSSDPQLMNGVLGESAVLPLKLPAGKIANIIIWNYEWEASQVTALVINLSNPESPQIMNTDVKKRLNITQSYSLQISNLTMADTGSYTAQITTKDSEVITFKYILRVFERLGNLETTNYTLLLENGTCQIHLACVLKNQSQTVSVEWQATGNISLGGPNVTIFWDPRNSGDQTYVCRAKNAVSNLSVSVSTQSLCKGVLTNPPWNAVWFMTTISIISAVILIFVCWSIHVWKRRGSLPLTSQHPESSQSTDGPGSPGNTVYAQVTRPMQEMKIPKPIKNDSMTIYSIVNHSREETVALTGYNQPITLKVNTLINYNS
What is the function of this protein?
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.  SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.  Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922).  Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (By similarity).  Positive signaling in NK cells implicates phosphorylation of VAV1.  NK cell activation seems to depend on SH2D1B and not on SH2D1A (By similarity).  In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (PubMed:18031695).  Promotes T cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (By similarity).  Promotes recruitment of RORC to the IL-17 promoter (By similarity).  In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response (PubMed:25926831).  In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells.  Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP (PubMed:22683125).  However, reported to mediated T-cell adhesion, to participate in stable T-cell:B-cell interactions and to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (PubMed:20153220, PubMed:25801429).  Involved in regulation of autoimmunity.  Isoform 3 may be suppressor of pathogenic T-cell proliferation (PubMed:21422172).
What are the official names of this protein?
SLAM family member 6, Lymphocyte antigen 108.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: BRK12_ASCTR
Sequence: APVPGLSPFRVV
What is the function of this protein?
Induces relaxation of mouse trachea that has been precontracted with methacholine.  May induce relaxation of arterial smooth muscle.  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
Bradykinin-like peptide AV-12.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: HSLV_RHIME
Sequence: MHATTIITVRKGGKVVMAGDGQVSLGQTVMKGNARKVRRLSKGDVIAGFAGATADAFTLLERLEAKLEQYPDQLMRAAVELAKDWRTNKYLRNLEAMMLVADRTVTLAITGNGDVLEPEHGTIAIGSGGNYAFAAARALMDSDKSAEEIARRALEIAGDICVYTNHNVVVETLDAE
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_PSEP1
Sequence: MSTIEERVKKIVAEQLGVKEEEVTIEKSFVDDLGADSLDTVELVMALEEEFETEIPDEEAEKITTVQAAIDYVKAHQA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIM14_CAEEL
Sequence: MYSNKSFQRRQRQQVAESRSEEKFSRSLVRLNAQSLLDSSGNNTTTKNVNSDVVIVVMEGRGSCEGHIGIALHDTCFPEIHLCEFVDSREYTTLKTMINVHEAFDIVIQNGNEERGSTKLLGEALMTAFPEASLQSISSKYFNSERGERQLQSLMNAEVSTVSEGCLRRTLALGALAVLLKYIHETRCVFFRVKSLRIKEMGVNDTCMIDFVSWESLEIVDADDASKARKFQMKQKRTLMSVLNHTVTTNGYRLLRSSVLQPSTDVYLIQSRQEAIEELIGKPQLKDKLRRTLSRAHELDRVIAMCIQTSTSWTVRESEAKINQIIKLMHTLKVIQGIRTLLHSAKMKSNILIEKTEFLKDPRFDQIMNILVEKVDDSLLDGKKNSLHLQNTKCYAIRHFVAVQLDLARQTYEEIIRNVEETGAREIAEYFHGNSSVRLSFSQSRGFHYTFVTRQAESVTIPRYFLDVFRNRTTVTFNSRKVIAYNDRLEQVVAEMFLASDVIVCDMIEEMQPMIPVLYYAMDALSSIDFLCGLATYSDLRDTCKPTFGPSFSISQGRHPILDWDDSEKTITNDTCLTRDRRFGIITGPNMAGKSTYLKQTAQLAIMAQIGCFIPANYASLPIFNRIFSRMGHNDELIRNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEEGIAITYAICEKVLKLQSYTFLATHFLDIAALANYSNAIDNYHFLPQTDENSTKKHKLLRGQYRGPLYGFELVELSTIPDEVIEHAQSLATELRANVEDTERDYDSERRRIKVYMNHRFRECAEYFMDTHGEKWKEEKEAIDKMKALRKYLVDELAKIDSQEQMCQ
What is the function of this protein?
Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes.  Together with msh-5 and zhp-3 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells (PubMed:23832114).  Not needed for pairing or synapsis.  May promote crossing over by interfering with Holliday junction branch migration.  Has no apparent role in DNA mismatch repair.
What are the official names of this protein?
MutS protein homolog him-14, High incidence of males protein 14, MutS protein homolog 4.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NIT1_YEAST
Sequence: MAKHIVAALQIGSCPGSTKDTLKKILSYEKEIKESGAKLVVIPEATLGGYPKGSNFGVYLGYRLQEGREEYAKYLAEAIEIGNGEKYPEISQLCALSKATDASLCVGCIERDGTTLYCTMVYIDPKDGYVGKHRKLMPTAGERLIWGQGDGSTLPVVDTAAGKIGGAICWENMMPLLRYAMYKKGVEIWCAPTVDARPI
What are the official names of this protein?
Putative nitrilase-like protein NIT1.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: URED_CORGB
Sequence: MTQTQPVGTLRLTIDDQGPQGQSRAVEQFHQGALRVIRPHYLDDSGQVSYTIIAIGGGYLGGDVYEQQFTVKDNAKALITTQSATKIYRTPQGPVTQYTEINVGENAVLEYLADQTIAYRESTYHQFTKVTLHPTSTFVMSEQITPGWHPDGKHFAYDEMRLHTEITDSTTGRLVLLDNLLLRPDSREGSFGWTEQYTHSGQMIVMGEGVDKQLVAELNEQLAAHPDVYGAVNFLSAPGTLLRGFIARTLSNRTEELINLHEHIASLLRGRWRGQEPVNLRKY
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_SALDC
Sequence: MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVGAVNGPIAQAILGKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKGKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKNITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PPR9_ARATH
Sequence: MRRFYRKPFSVPLLNRPHCSSQSHCLYKNGDFLSDDSKCSPLSSSRTSVRWVFNSSSLPPPEWIEPFNDVSDLVKSNRNLLPSPWVSQILNLLDGSASMESNLDGFCRKFLIKLSPNFVSFVLKSDEIREKPDIAWSFFCWSRKQKKYTHNLECYVSLVDVLALAKDVDRIRFVSSEIKKFEFPMTVSAANALIKSFGKLGMVEELLWVWRKMKENGIEPTLYTYNFLMNGLVSAMFVDSAERVFEVMESGRIKPDIVTYNTMIKGYCKAGQTQKAMEKLRDMETRGHEADKITYMTMIQACYADSDFGSCVALYQEMDEKGIQVPPHAFSLVIGGLCKEGKLNEGYTVFENMIRKGSKPNVAIYTVLIDGYAKSGSVEDAIRLLHRMIDEGFKPDVVTYSVVVNGLCKNGRVEEALDYFHTCRFDGLAINSMFYSSLIDGLGKAGRVDEAERLFEEMSEKGCTRDSYCYNALIDAFTKHRKVDEAIALFKRMEEEEGCDQTVYTYTILLSGMFKEHRNEEALKLWDMMIDKGITPTAACFRALSTGLCLSGKVARACKILDELAPMGVILDAACEDMINTLCKAGRIKEACKLADGITERGREVPGRIRTVMINALRKVGKADLAMKLMHSKIGIGYERMGSVKRRVKFTTLLETCFDS
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g03560, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HISX_SHIFL
Sequence: MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKTRGDEALREYSAKFDKTTVTALKVSADEIAAASERLSDELKQAMAVAVKSIETFHTAQKLPPVDVETQLGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPARIAGCKKVVLCSPPPIADEILYAAQLCDVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDADMARRVAEAVERQLAELPRAETTRQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDGITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNVLKEQA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: HIS6_SALHS
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYADEGADELVFYDITASSDGRVVDKSWVARVAEVIDIPFCVAGGIRSIDDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWFDDATGKYHVNQYTGDENRTRVTQWETLDWVQEVQQRGAGEIVLNMMNQDGVRNGYDLTQLKKVRDVCRVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLAGQGVEIRIC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECQ5_MOUSE
Sequence: MSARPFSTPFDRERRVRSTLKKVFGFDSFKTPLQESATMAVVKGAEDVFVCMPTGAGKSLCYQLPALLASGITIVVSPLIALIQDQVDHLLALKVQVSSLNSKLSVQERKELLSDLERDKPRTKLLYITPEMAASASFQPTLNSLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDVFAALHLKQPVASFKTPCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQKAENGSSSGCGIVYCRTREACEQLAIELSSRGVNAKAYHAGLKASDRTQVQNEWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKPSDKATLLAFDALVTFCEEVGCRHAAIAKYFGDAPPACAKGCDYCQNPAAITKKLDALERSSSWSKTCIGPSQGNGFDPELYEGGRRGYGGFSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMSLRKGKEPKIEEFTPPDEDCPLREASSRKIPKLTVKAREHCLRLLEEALISNHQAAGSTHGADLQAKAVELEHETFRNAKMVNLYKASVLKKVAEIHKASKDGQLYDMESGTKSCGAAAEFSEPSDYDIPPTSHVYSLKPKRVGAGFSKGPCSFQTATELLGKSHSQKQAPEAMLEGGQEPPGWVCDLQDEDRSKPHPGYQEKALGSSVNCGDPSPEKKTKGSSQGSAKARASKKQQLLATAARKDSQNITRFLCQRTESPPLPASVPRSEDASPSCGDVPGKCTQEVGAQGHLVAVFQTEGPRERPSTCSLRDQSFPEGQPSPLKETQAEKRPRPQQGNPERRAQKRLRPSTKSSILAEAKDSTLASDRSTENKVAQEPCQLSASGTSLREAADIVVRHLTPFYKEGRFISKDLFKGFARHLSHLLAQQLSPGRSVKEEAQSLIKQFFHNRARCESEADWHSLRGPQR
What is the function of this protein?
DNA helicase that plays an important role in DNA replication, transcription and repair.  Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability.  Associates also with POLR1A and enforces the stability of ribosomal DNA arrays.  Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress.  Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis.  Required for efficient DNA repair, including repair of inter-strand cross-links.  Stimulates DNA decatenation mediated by TOP2A.  Prevents sister chromatid exchange and homologous recombination.
What are the official names of this protein?
ATP-dependent DNA helicase Q5, DNA helicase, RecQ-like type 5, RecQ5, RECQL5beta, RecQ protein-like 5.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks.