PharMolix/UniProtQA huggingface dataset:
Protein: ARGC_STAA1
Sequence: MIKVGIVGGSGYGAIELIRLLQTHPHVTIAHIYSHSKVDEPLKLTFPHLQHIMQHFEALTVDNNDCDVIFFATPAPVSKTCIPPLVEKGIHVIDLSGAFRIKNREIYEAYYKETAAAQDDLNHAIYSISEWQSFDNNGTKLISNPGCFPTATLLALHPLISEKIVDLSSIIIDAKTGVSGAGRSLSQRVHFSEMNENLSAYAIGNHKHKPEIEQYLSIIAGQDVSVIFTPHLVPMTRGILSTIYVKFSSEYTTESLHKLMTSYYANQPFVRIRDIGTFPTTKEVLGSNYCDIGIYVDETTQTAILVSVIDNLVKGASGQAIQNLNILYDFEVTTGLNQSPVYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_STRZJ
Sequence: MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAVLAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLRAERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YA95_BACC1
Sequence: MIVTTTSGIQGKEIIEYIDIVNGEAIMGANIVRDLFASVRDVVGGRAGSYESKLKEARDIAMDEMKELAKQKGANAIVGIDVDYEVVRDGMLMVAVSGTAVRI
What are the official names of this protein?
UPF0145 protein BCE_1095.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: APOE_ATEGE
Sequence: MKVLWAALLVAFLAGCQGKMEPELEREPELEREPELHQQADWQSGQPWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLSPVAEETRARLSKELQAAQARLGADMEDVRSRLAXYRSEVQAMLGQSXDELRARLASHLRKLRKRLLRDVDDLQKRLAVYQAGAREGAERGVSAIRERLVPLVEQGRARAATVGSSLAGQPLQERAQAWGERLRARMEEVGSRTRDRLDEVKEQVEEVRAKLEEQAQQMRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGASAAPVPGDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: ACCA_KLEP7
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQVAQLARHPRRPYTLDYVRLAFDEFDELAGDRAFADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMAERFKMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLSVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIVPEPLGGAHRNPEAMAASLKAQLLADLADLDLLSEEELLNRRYQRLMSYGYA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DB132_GORGO
Sequence: MKFLLLVLAALGFLTQVIPASAGGSKCVSNTPAYCRTYCHWGETALFMFNASRKCCISYSFLPKPDLPQLIGNHWQSRRNTQRKDKKQQTTVTS
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 132, Defensin, beta 132.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECO_SHISS
Sequence: MEGWQRAFVLHSRPWSETSLMLDVFTEESGRVRLVAKGARSKRSTLKGALQPFTPLLLRFGGRGEVKTLRSAEAVSLALPLSGITLYSGLYINELLSRVLEYETRFSELFFDYLHCIQSLAGATGTPEPALRRFELALLGHLGYGVNFTHCAGSGEPVDDTMTYRYREEKGFIASVVIDNKTFTGRQLKALNAREFPDADTLRAAKRFTRMALKPYLGGKPLKSRELFRQFMPKRTVKTHYE
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: EGLD_ASPOR
Sequence: MKSSTFGMLALAAAAKLVSAHATVHAVWINDVDQGEGNSESGYIRSPPSNSPITDVTSKDMTCNVNNKATAKTLEVKAGDKITFEWHHDSRSDSDDIIASSHKGPIMVYMAPTEKGTAGNGWVKIAEDGYTDGTWAVDTLIKNRGKHSVTVPDVAAGEYLFRPEIIALHEGNRQGGAQFYMECVQVKVTSSGSKTLPEGVSIPGAYTATDKGILFDIYNSFDSYPFPGPAVWDGASGSSSSPSASASASAPAATSAAPAPSSFTTIAKQPATSSTEAPSTENTSTTSTIVSTTAAASATAPATPSSTSAIASSAASTNSVPQPSSNAGGAVKEWYQCGGLNYKGSTQCEEGLTCKKWNPYYYQCISA
What is the function of this protein?
Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan.  Involved in the degradation of complex natural cellulosic substrates (By similarity).
What are the official names of this protein?
Probable endo-beta-1,4-glucanase D, Endoglucanase D, Carboxymethylcellulase D, Cellulase D.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 61 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FIXK_RHIME
Sequence: MYAAAQAKPQSIEVEHLGPAPMSGPRLVATYKPGREIYAQGDLNDKCYQVSTGAVRIYRLLSDGRRQVVSFHLPGEMFGFEAGSNHSFFAEAITETTLAIFGRRNMQERSRELLALALTGMARAQQHLLVIGRQCAVERIAAFLVDLCERQGGGRQLRLPMSRQDIADYLGLTIETVSRVVTKLKERSLIALRDARTIDIMKPEALRSLCN
What is the function of this protein?
FixK is a protein that regulates nitrogen fixation genes both positively and negatively.  FixK appears to repress its own expression and that of nifA.  FixK may bind DNA at the FNR consensus binding site.
What are the official names of this protein?
Nitrogen fixation regulation protein FixK.
Protein: U598_DROME
Sequence: MLFLDDAKMKNFTSCFKEKDFLKFFFNRLRLNKTSRYESEFPYISLCGRERNFIRCDDTPVVFTEQLRKDDTEVLSYAHAGQVLTLPYEPHKLYMDPRNGRVYHPAAPQVGGIGLVRSKLAIELSQHFEFLAGEASPTHFQWNGERLELQNEWVNNTQRFPMNEDCK
What are the official names of this protein?
UPF0598 protein CG30010.
What is the protein family that this protein belongs to?
Belongs to the UPF0598 family.
Protein: YAFX_ECOLI
Sequence: MTTQTQHDLAPANQPEFELTVTPVPDEQRIDFWPQYFGAIPQWLLLEPHIFAWMDRFCEGYSGGIWSFYTLSNGGAFMSPEPDNDETWRLFNCLNGNDAQMSAEAAGIAVCLIAYSHHACRTECDAMTAHYYRLREYAMQHPEAHAILRIID
What are the official names of this protein?
Uncharacterized protein YafX.
What is the protein family that this protein belongs to?
Belongs to the antirestriction protein family.
Protein: IF3_BRUSU
Sequence: MRRPFRATPVQKDGPRSNRDIRVPRVQLIDAEGQNHGDVSIQEAMAMAEEAGLDLVEIVPNAEPPVCKIVDLGKLKYQNQKKAAEARKKQKTVEIKEIKMRPNIDTHDYEVKMKAAQRFFEEGDKVKVTLRFRGREMAHQELGMKLLQRVKEDTVEIAKVESEPKLEGRQMMMVLAPR
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTGC_ASPNC
Sequence: MAGVNRSFSYSRGDDALLRDDEREISPLRSAEDGLYSTSYGDVSPLSAGVQAQNRPFDRGLVSVPEGQTLERHMTSTPGMDNLGPASVGGGISGIALGVANSHNRQSGVDAFRETDVPVRNLPAERDFNTTGSDNPYIPAPPDGDIYPSSEAVRYRDSYSSHTGLGAGAPFAEHSTPGTTPSQRSFFDSPYQGVDAGPYQRHSAYSSHDYPLVINPDDIADDGDDGFPVHPKGAADYRSNANVPGTGVAGAAAAGGFLGKFRALFKREEPSPFYDSDIGGGLGGAEKAQGGRHIIGGGSRKRGWIVGLILAAVIVAAIVGGAVGGILGHQEHDGDTSSSSSSSSSSGTGSGGSDKGDGLLDKDSDEIKALMNNKNLHKVFPGVDYTPWGVQYPLCLQYPPSQNNVTRDLAVLTQLTNTIRLYGTDCNQTEMVLEAIDRLQLTNMKLWLGVWIDTNTTTTDRQISQLYKIVENANDTSIFKGAIVGNEALYRAGSDVASAETNLIGYINDVKDHFKDKNIDLPVGTSDLGDNWNAQLVSAADFVMSNIHPFFGGVEIDDAASWTWTFWQTHDTPLTAGTNKQQIISEVGWPTGGGNDCGSDNKCQNDKQGAVAGIDELNQFLSEWVCQALDNGTEYFWFEAFDEPWKVQYNTPGQEWEDKWGLMDSARNLKPGVKIPDCGGKTIT
What is the function of this protein?
Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.  This enzyme may be involved in beta-glucan degradation.  Active on laminarin and lichenan (By similarity).
What are the official names of this protein?
Putative glucan endo-1,3-beta-glucosidase btgC, Endo-1,3-beta-glucanase btgC, Laminarinase btgC.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: YGAD_BACSU
Sequence: MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVDDIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLFDHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTLDVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFAIEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPLTVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKADQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFYDVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIEAAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSALDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDYESQYKHLFTIQNLN
What is the function of this protein?
May be involved in multidrug export.  Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity).
What are the official names of this protein?
Putative multidrug export ATP-binding/permease protein YgaD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y4OS_SINFN
Sequence: MTGMVGTILRRKAEQNMTDVTIRNVTKRYGALTVIPQLSFRIEDGEFVVLVGPSGCGKSTLLRMLAGLEEISGGDLLMGADVINDRPAKERDMAIVFQNYALYPHMTVAENMGFALKLRKRPRAEIDERVDKAAAILGLGKLLDRYPRALSGGQRQRVAMGRAIVRDPQVFLFDEPLSNLDAKLRVQMRAEIKALHQRLKITTVYVTHDQIEAMTMADKIVVMNEGRVEQMGTPLELYDRPANIFVAGFIGSPSMNFLPATVAATNGPLLKTPEGVALPIDGGPTLTGRSEVTYGIRPEHLQLGETGIPAEVVVVEPTGSETQLYVTVGGREVVAVLRDRVDVRPGEKIWLTPRKGCAHLFDPNTGARIAG
What is the function of this protein?
Probably part of a binding-protein-dependent transport system y4oPQRS.  This system probably transports a sugar-like molecule.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein y4oS.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ECFA2_LACLA
Sequence: MIKFEKVNYTYQPNSPFASRALFDIDLEVKKGSYTALIGHTGSGKSTLLQHLNGLLQPTQGTVRVGDIVVTSTSKQKEIKPVRKKVGVVFQFPESQLFEETVLKDVAFGPQNFGISKEEAEKIAAEKLEMVGLSKEFWEKSPFELSGGQMRRVAIAGILAMEPEVLVLDEPTAGLDPKARIEMMKLFESIHQTGQTVVLVTHLMDDVADYADYVYLLEKGHIISCGTPSDVFQEVDFLKAHELGVPKATHFADQLQKTGVYTFEKLPITRAELVNLLTSLSVKSGGEN
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HUTU_SHEPW
Sequence: MDKRHDPSRRIIAPTGTKLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWECYDKIVEVLQRLEDDETLLVQSGKPVGVFKTHSNAPRVIIANSNLVPHWANWEHFNELDKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHFGGSSKGKWILTGGLGGMGGAQPLAGTMAGYSVLTCEVDETRIDFRLRTRYVDKKATTLDEALAMIDEANASGKPVSVGLLANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEQAAQMRKTDEAAVVKAAKQSMAVQVKAMLALQAAGSATTDYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPFRWAALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPSRICWVGLKDRARLALAFNEMVNNGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTASGATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAARLGRVLWNDPATGVMRHADAGYDIAKDCAKEQGLDLPMLEK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTFA_ECO8A
Sequence: MIKWPWKVQESAHQTALPWQEALSIPLLTCLTEQEQSKLVTLAERFLQQKRLVPLQGFELDSLRSCRIALLFCLPVLELGLEWLDGFHEVLIYPAPFVVDDEWEDDIGLVHNQRIVQSGQSWQQGPIVLNWLDIQDSFDASGFNLIIHEVAHKLDTRNGDRASGVPFIPLREVAGWEHDLHAAMNNIQEEIELVGENAASIDAYAASDPAECFAVLSEYFFSAPELFAPRFPSLWQRFCQFYQQDPLQRLHRTNDTDSFSATNVH
What is the function of this protein?
Involved in the regulation of ptsG expression by binding and inactivating Mlc.
What are the official names of this protein?
Protein MtfA, Mlc titration factor A.
What is the protein family that this protein belongs to?
Belongs to the MtfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_GLOC7
Sequence: MLNKPEVPIEAIEAREILDSRGKPTVEAEVRLETGAVGMAQVPSGASTGTFEAHELRDGDPSRYGGKGVTIAVRNIHEKIAPSILDMDAFDQVSVDLKMIQRDGTPNKKELGANAILAVSLATAKAAAAELDIPLYRYLGGPLSNVLPVPMMNVLNGGAHADNNVDFQEFMIMPIGADSFREALRWGAEVFACLSSVLKERKLLSGVGDEGGYAPNLGSNQEALDLLMEAIDKAGYKAGEQIALAMDVASSEFYKDGQYIYDGSAHSPQEFIDYLDKLVSQYPIVSIEDGLAEEDWDNWKILTDQLGSRIQLVGDDLLVTNPTRLQKAIDMGVANSILIKLNQIGTLTETLETIDLATRNKYRSVISHRSGETEDTTIADLAVATRAGQIKTGSLCRSERVAKYNRLLRIEDELGDRAVYAAKIGLGPKA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: VIP2_MOUSE
Sequence: MSNSRKMSEPPRFFVGPEDAEINPGNYRRFFHHAEEEEEEEDESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEEIILNEPVENWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYLIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQEVLDIARQLLMELGQNNDSEIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRYRMEDPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDDSKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRSLKTDDDEPHTSKRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKITANEVVSENANYLRTPRNLVEQKQNPTVGFELYSMVPSICPLETLHNALFLKQVDDFLASIASPSTEVLRKVPEMSSMATRSSPGMRRKISLNTYTPTKILPTPPAALKSSKASSKAAAGGPSQAMAPHTSSRKKSINSKTEGHEPKKSTGKKR
What is the function of this protein?
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096).  PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096).  Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096).  Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096).  Required for normal hearing (PubMed:29590114).
What are the official names of this protein?
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, Diphosphoinositol pentakisphosphate kinase 2, Histidine acid phosphatase domain-containing protein 1, InsP6 and PP-IP5 kinase 2, VIP1 homolog 2, mmVIP2.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MNHB2_STAHJ
Sequence: MKENDVVLRTVTKIVVFILLTFGFYVFFAGHNNPGGGFIGGLIFSSAFILMFLAFDVHEVLESLPIDFKKLMIVGAIISALTAIVPVFFGKSFLYQSEAYIHFPLLGELHVTTITLFELGILLTVVGVIVTIMLALSGGKS
What are the official names of this protein?
Putative antiporter subunit mnhB2, Mrp complex subunit B2, Putative NADH-ubiquinone oxidoreductase subunit mnhB2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL5_STRPZ
Sequence: MANRLKEKYTNEVIPALTEKFNYTSVMAVPKVEKIVLNMGVGDAVSNAKNLEKAAAELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEISFDDVDKVRGLDIVIVTTANTDEESRELLKALGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: METXA_MOOTA
Sequence: MDGVGIVTTRFYEWSQCLHLESGAQLGSLTIAYETYGELNAAGNNAILVLHALTGNAHIAGRNFPDERYPGWWDPLVGPGRALDTRRYFIVCANVLGSCYGTTGPASINPATGKPYGMDFPAITIRDMVRAQKILLDYLGVKRLVAAIGGSMGGMQVLEWGFLYPQMLDAIIPIATCGRTTPMQIAFHHVQREAIYADPDWQGGNYYGTAGPRRGLALARQIGIITYKSDPSWNMKFGRNLVDPRKYFQLEGQFEVESYLAYQGRKLVDRFDANSYLYLTKAVDLHDVSQGRGSYNEVWRDFPCPCLGIGISSDFLFPPYQVQEIVRMINDGGGHARYAEIDSPYGHDAFLIEFNQLAAIIQPFLKELRPDLAA
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYS3_YEAST
Sequence: MTLQESDKFATKAIHAGEHVDVHGSVIEPISLSTTFKQSSPANPIGTYEYSRSQNPNRENLERAVAALENAQYGLAFSSGSATTATILQSLPQGSHAVSIGDVYGGTHRYFTKVANAHGVETSFTNDLLNDLPQLIKENTKLVWIETPTNPTLKVTDIQKVADLIKKHAAGQDVILVVDNTFLSPYISNPLNFGADIVVHSATKYINGHSDVVLGVLATNNKPLYERLQFLQNAIGAIPSPFDAWLTHRGLKTLHLRVRQAALSANKIAEFLAADKENVVAVNYPGLKTHPNYDVVLKQHRDALGGGMISFRIKGGAEAASKFASSTRLFTLAESLGGIESLLEVPAVMTHGGIPKEAREASGVFDDLVRISVGIEDTDDLLEDIKQALKQATN
What is the function of this protein?
Catalyzes the production of cysteine from cystathionine in the reverse transsulfuration pathway for the biosynthesis of sulfur-containing amino acids cysteine and methionine.  In this pathway, homocysteine sulfur is converted to cysteine sulfur (Probable).  Also has cystathionine beta-lyase and cystathionine gamma-synthase activities in vitro.  Cystathionine beta-lyase may be physiological, while cystathionine gamma-synthase activity is not, as the required substrate O-succinyl-L-homoserine(OSH) does not occur naturally in S. cerevisiae (PubMed:8335636).
What are the official names of this protein?
Cystathionine gamma-lyase, gamma-CTLase, Gamma-cystathionase, Sulfur transfer protein 1.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_ACHLI
Sequence: MAVPFRRQSKGRKRRRRSHYKLKTPTIVVDPQTGEFTLPHRVTPNSGYYKGQLVLAKKVKKED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.