PharMolix/UniProtQA huggingface dataset:
Protein: LEXA_MYCVP
Sequence: MSDDSSDSTSGAGSGRGRDSGLTERQRTILDVIRASVTSRGYPPSIREIGDAVGLTSTSSVAHQLRTLERKGYLRRDPNRPRAVDVRGSDDHAAPIVATDVAGSDSLPEPTFVPVLGRIAAGGPILAEEAVEDVFPLPRELVGEGSLFLLKVVGESMIDAAICDGDWVVVRQQSVADNGDIVAAMIDGEATVKTFKRTKGQVWLMPHNPAFDPIPGNDAAILGKVVTVIRKI
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RL9_CHLFF
Sequence: MKQQLLLLEDVDGLGRSGDIVTARPGYVRNYLLPQKKAIIAGAGTLRLQAKLKEERLLRAAEDRAESEKLAELLKDLVLEFQVRVDPDNNMYGSVTISDIIAEAAKKNVILTRKNFPNAHYAIKNLGKKSVPLKLKEGVTATLFVEVSSESAYIAVLNQQSSQEQTVAAEELE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y3149_BORPD
Sequence: MPLPADLPPHERPRERLLRHGPASLRDAELLALALRTGTRGRTAIDMGSQLLHRYGGLRGLFAASPQELMSLPGLGAAKAGTLAAILELARRAAEERLMRQQAMSEPGSVKRYFKTALANCAVEHCLALYLDSQLNLITSGELARGTLARASVYPREVVREALRHHAAALILAHNHPSGSAQPSQADRDFTRHMQQALALVEIRLLDHLIVAGDTVVSMAELGLL
What are the official names of this protein?
UPF0758 protein Bpet3149.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: ANKL1_MOUSE
Sequence: MADTACLALRLLAALREEEARAVEELLRLGADPNLVLDDGAAAVHLAARASHPRALHCLRMLLRWGADPNARSAEGLTPVHVAAAWGCCGALELLLSRGGDPTLRDQDGLRPLDWALQQRHHNCARVLQELDTPTQPDETREPTETFHVAQGSFETETCQGPALAESSGVSQDSELHVHRAELEVEAVEVAVHPQSSEATENSDYSSDASFVTAVEDSLQPGRPGGALELVAGLWVTRGAVSAGKGAPNCQPQVLTLTARDTDKPVLPGDGDLGALHPHSSVPPMSDLQLLQALRALGYSPGPVTPFTRGHYLRRLQEAQASRADVGHSQELAEALRTGTIPDCQVDEEALAQCFQRLDPLKKWREGITKSSFTYLLLDPRLTKDLPARASSLTLAECLQCFVRAIFYVGKGTRARPDAHLWEAFGYHDQPRKQVCPKVRRILDIWASGRGIISLHCFQHVVAMEAYTREACLLDALGLQTLTNQKQGHYYGVVAHWPPSRRRRLGVHLLQRALLVFLAEGERELRPQDIQARG
What is the function of this protein?
Endonuclease that probably plays a role in the DNA damage response and DNA repair.
What are the official names of this protein?
Ankyrin repeat and LEM domain-containing protein 1, Ankyrin repeat domain-containing protein 41, LEM-domain containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=At the steady state, predominantly localizes in the cytoplasm.
Protein: YDEO_ECO57
Sequence: MSLVCSVIFIHHAFNANILDKDYAFSDGEILMVDNAVRTHFEPYERHFKEIGFNENTIKKYLQCTNIQTVTMPVPAKFLRASNVPTGLLNEMIAYLNSEERNHHNFSELLLFSCLSIFATCKGFITLLTNGVLSVSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIRVEGSVNKIAEQCGYASTSYFIYAFRKHFGNSPKRVSKEYRCQRHTGMNTGNTMNALAI
What is the function of this protein?
Induces the expression of gadE and mdtEF.  Could also regulate the expression of other genes involved in acid resistance (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator YdeO.
Protein: SYP_METM7
Sequence: MEFSEWYSDILEKAGIYDLRYPIKGCGVYLPYGFKIRRYSFEILRKLLDETGHDETLFPMLIPENLLAKEGEHIKGFEDEVFWVTHGGKTPLEVKLALRPTSETTMYYMMKQWIKVHTDLPLKLYQVVNTFRYETKHTRPLIRLREIMSFKEAHTAHATKEDCDAQIKEALNLYGEFFDEICVPYIISKRPEWDKFPGADYTMAFDTIYPDGKTMQIGTVHNLGQNFAKTFELEFETPDGEKDFVYQTCYGISDRAIASLISVHGDEKGLVIPVDVAPIQIVLIPLLFKGKEEIVMEKIKELNSTLKSEFRVHLDDRDIRPGRKYNDWEIKGVPLRIELGPRDIENGQALIVRRDTGEKITVEYSNILEEVEKIVSMYKENLKIKADEKIKNFLTVVDFESDVNALSEKVKAALLENKGIILIPFDESVYNEEFEELIDASVLGQTTYEGKDYISVARTY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPR9_CAEEL
Sequence: MQAIHENYTDNPSSSITRERQHEDMKGAQFVVQSNLKIMSRSIAALSKISEDVLIEVSEGGLFFKTVNRSKFCVFRFAPEFFNACDVSMINKKAVNICRLSMKSAQRIFKGVAFGEKNFVGCEFRIDPKAERMMVKLQMNYDIERTIHAKLREMGSMLHKPTYNRSGCRNITVVFASTLLPIFVQMKGDIEVTMKVTDDGLTIRNFHSLDGVTMFNMGVEKGAKKVKTETTITCEKLTRHKIQIPVEFSFSIKEFLSIVTFADQLGSEVCMYYDLPGKPLIVSIEAHPNFDIELALATMGSDDEIDLDGGILKETMAQHEEEEDKSTAHSSSSRRKSKAIDTSSSGTQKSKKCSESLSQEETTRSQSLPSRNRFVPEIPVAEQSWRDREVTVYEQREPSPDLQIVEEVMEIDNQPIVTRTIKEEHSVEQAMQDVSIETIPVETPEENIIPVEVEMLEEPEQEDQEIFKIPQPKRRKTAEDDRNRKIRRILMGTETTSKMRMSQQFDKRLGPLVSDTQYESR
What is the function of this protein?
May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.
What are the official names of this protein?
Cell cycle checkpoint protein hpr-9.
What is the protein family that this protein belongs to?
Belongs to the rad9 family.
Protein: RL22_BACC3
Sequence: MQAKAVARTVRIAPRKVRLVVDLIRGKQVGEAIAILNHTPKTASPVVEKVLKSAIANAEHNYEMDINSLVVEKVFVDEGPTLKRFRPRAMGRASQINKRTSHITVVVSEKKEG
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: KTHY_BDEBA
Sequence: MRCKMKFIVFEGLDGSGKSSLMAALERELQNRAINFLRTREPGGTPLGDEIRNMILRKEGPAPTPRTELLLYEASRSQHVDQVIRPALAAGTWVLCDRFAASSVAFQSGGRAISEADVVMLNTFATGGLKADITVLLDLSVEESRRRRQGRGAVTGETEDRIESEADTFHENVRQSFLKQSREDAAAWIVLDARETPEVLFKQLLQSLTERKVL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RL28_ORITI
Sequence: MSRVCELTGVSVQSGHNVSHSQRKTKRKFLPNLQNVSLFSDSLKKAFKFKVVARAMRTLDKVGGLDCYLLSASDKTLSKSAIEVKKIIKNNESKS
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RS7_MARN8
Sequence: MPRRRVAAKREIIPDPKFGSARLAKFINHVMESGKKSVAERIVYGALDIVAEKSKEEPIEMFEKALENIQPMVEVKSRRVGGATYQVPVEVRPSRQNALAMRWLVEYSRKRGEKSMAQRLAGEILDAADSKGAAVKKREDVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ILVA_LACLA
Sequence: MISAKEVEDAYDLLKAVVTKTPLQLDPYLSNKYQANIYLKEENLQKVRSFKLRGAYYSISKLSDEQRSKGVVCASAGNHAQGVAFAANQLNISATIFMPVTTPNQKISQVKFFGESHVTIRLIGDTFDESARAAKAFSQDNDKPFIDPFDDENVIAGQGTVALEIFAQAKKQGISLDKIFVQIGGGGLIAGITAYSKERYPQTEIIGVEAKGATSMKAAYSAGQPVTLEHIDKFADGIAVATVGQKTYQLINDKVKQLLAVDEGLISQTILELYSKLGIVAEPAGATSVAALELIKDEIKGKNIVCIISGGNNDISRMQEIEERALVYEGLKHYFVINFPQRPGALRTFVSDILGPNDDITRFEYIKRADKGKGPCLVGILLSDASDYDSLIDRIERFDNRYVNLHGNDSLYELLV
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
What are the official names of this protein?
L-threonine dehydratase biosynthetic IlvA, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: PANB_MARMM
Sequence: MSAQSKSPTKARRITAPDIRARKGGEPLVCLTAYDAPMARILDPHCDLLLVGDSVGMVVHGLDSTVGVTLDMMILHGQAVMRGARQALVAVDMPFGSYEQSPEQAFANAARVMAETGCQAIKIESGTYAADTIRFMAARSIPVIGHIGLRPQAALADGGFRAKGRTQAERQRVIDEALATAEAGAFAIVIEGVAEDLAREITETVDVPTIGIGASAACDGQILVTQDMLGVFDWTPKFVKRYDNMAERTDAAVAQFASDVRDRSFPSQREVYTMKRSDG
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMED5_MOUSE
Sequence: MGGRMWLPFPVLLLSALPAALLRGAAGFTPSLDSDFTFTLPAGRKECFYQPMPLKASLEIEYQVLDGGELDIDFHLTSPEGRTLVFEQRKSDGVHTIETEDGDYMFCFDNTFSTISEKVIFFELILDNMGEEVQGQEDWKKYITNTDVLEMKLEDILESINSIKSRLSKSGHIQTLLRAFEARDRNIQESNFDRVNFWSVVNLMVMVVVSAIQVYTLKSLFEDKRKSRT
What is the function of this protein?
Potential role in vesicular protein trafficking, mainly in the early secretory pathway.  Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly.  Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).
What are the official names of this protein?
Transmembrane emp24 domain-containing protein 5, p24 family protein gamma-2, p24gamma2.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Probably cycles between compartments of the early secretatory pathway.
Protein: ARLY_RALSO
Sequence: MTSQLAKKAEAWSARFNEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAAIEQGMAQIRQEIEAGTFEWKLDLEDVHLNIEARLTAMAGDAGKRLHTGRSRNDQVATDIRLWLRSEIDNIVGLLRALRGALLDLAEQHTNTIVPGFTHLQVAQPVVFGHHLLAYVEMFTRDTERMLDARKRVNRLPLGAAALAGTSYPIDREFVAQQLGFDGVCRNSLDAVSDRDFAIEFCAAAALVMTHISRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLIGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGITVKADAMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVRACDDLRCDLADLSVTQLREISGLGDKANLIGDDVHAVLTLEGSVASRNHIGGTAPEQVRLAIVAARAGLAG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PENK_RAT
Sequence: MAQFLRLCIWLLALGSCLLATVQADCSQDCAKCSYRLVRPGDINFLACTLECEGQLPSFKIWETCKDLLQVSKPEFPWDNIDMYKDSSKQDESHLLAKKYGGFMKRYGGFMKKMDELYPVEPEEEANGGEILAKRYGGFMKKDADEGDTLANSSDLLKELLGTGDNRAKDSHQQESTNNDEDSTSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAESLPSDEEGESYSKEVPEMEKRYGGFMRF
What is the function of this protein?
Increases glutamate release in the striatum.
What are the official names of this protein?
Proenkephalin-A.
What is the protein family that this protein belongs to?
Belongs to the opioid neuropeptide precursor family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen.
Protein: DNAJ_LACJO
Sequence: MAQRDYYDVLGVDKNASESEISKAYRKLAKKYHPDLNHEPGAEEKYKEVNEAYEVLHDKQKRAQYDQFGQAGVNGQGGFGGQGFGGFGGQGGYSSQGFGDFGDIFGDIFGSAFGGGRSRVDPTAPQKGQDLDYTMTIDFMDAIKGKKTDITYTRSEVCPTCDGSGAEKGTHPITCDKCHGSGVMTVTRQTPLGVIQQQTTCDKCGGRGTIIEHPCQTCHGQGTVDKKQTLQVTVPAGIDNGQQIRLSGQGEAGKNGGPYGDLYIVFRVKPSKEFRRNGTTIYTEAPISFAQAALGDKIRVNTVHGPVDLTIPAGTQPNTNFKLRGQGVPKINGTGNGDQEVTVKVVIPKKINDKQKEALVDYVKAGGGNISPQEKNFFERLKDKLNGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1A_SACS2
Sequence: MPKKDRAQEAPSRDVPRPEEGQTICVVKKMLGGDHLIVLCMDGKERLARIPGKIRKKMWMREGDVVLVGIWDFQPNRCDILYKYGNDEIKRLVNENIISREVIDQLRG
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
What are the official names of this protein?
Translation initiation factor 1A, aIF-1A.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: GUDU_DROME
Sequence: MIGTSSGTSHNRSRKKKEQCGSCPNRFSKDKRQVAAEDSDTTEVESSTDEEERWKEVARAAEIPADYYNIQKLVKYIKAGNQTATIVSLCCLKDYDLSTQINQFAISDIGGLDVLVNILECSDTKCCLGALKVLSDITLNIDIRKTIVDLDGIPLIVDILNSSMKDLKTMAAETLANVCKVRLARKYVRTCGGIPKLVDLIDIKLSILKTPRDQLSPDDLESLDMTRAGARALFTLADSKHNMEQMRKSGIVPLMAQLLKSCHIDVVIPIMGTVRKCSSEPKFQLAITTEGMIPDIVSHLSSENTELKMEGSTAIYKCAFDGTTRDLVREAGGLEPLVTIIKDKNVRENKPLLRGATGAIWMCAVTDANVKVLDQLRTVNHLVALLNDECDEVLTNVTGAISECVRFQSNREQLRQAGGLPAMVSLLNSSHAPLLENLAKGLKECAEDPDSMRILEDLDAVRLIWSLLKNPTTRVQAHAAYAICPCVRNANDSAELVRSLVGAMELVVGLLKSKDIMVLSAVCAAIATIAQDQTNLAILTDLKVIYKLADLVQTTDDLLRMNLAAAVAACACFGNNTEELGRLRTVTPIVTYMTSDNPLVHRSTAMALEKLSMDPQNCITMHQSGVVPFLLECIGSTNKELQLAAAGCLRNIRELALRAEEYLLKIDDD
What is the function of this protein?
Important for spermatogenesis where it may have a role in sperm individualization.
What are the official names of this protein?
Armadillo repeat-containing protein gudu.
Protein: NAGA_HUMAN
Sequence: MRGEQGAAGARVLQFTNCRILRGGKLLREDLWVRGGRILDPEKLFFEERRVADERRDCGGRILAPGFIDVQINGGFGVDFSQATEDVGSGVALVARRILSHGVTSFCPTLVTSPPEVYHKVVPQIPVKSGGPHGAGVLGLHLEGPFISREKRGAHPEAHLRSFEADAFQDLLATYGPLDNVRIVTLAPELGRSHEVIRALTARGICVSLGHSVADLRAAEDAVWSGATFITHLFNAMLPFHHRDPGIVGLLTSDRLPAGRCIFYGMIADGTHTNPAALRIAHRAHPQGLVLVTDAIPALGLGNGRHTLGQQEVEVDGLTAYVAGTKTLSGSIAPMDVCVRHFLQATGCSMESALEAASLHPAQLLGLEKSKGTLDFGADADFVVLDDSLHVQATYISGELVWQADAARQ
What is the function of this protein?
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.  Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
What are the official names of this protein?
N-acetylglucosamine-6-phosphate deacetylase, GlcNAc 6-P deacetylase, Amidohydrolase domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. NagA family.
Protein: RL11_CLONN
Sequence: MAKKVVGMIKLQLPAGKATPAPPVGPALGQHGVNIMAFCKEYNAKTANQAGMTIPVIISVYQDRSFSFILKTPPAAVLIKKAAGLDSGSGEPNKTKVGKITKAQLKEIAETKMPDLNAGSVESAMSMIAGTARSMGITVEE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: EXOS9_MOUSE
Sequence: MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLLERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGEEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGIMLLKDQVFRCSKIAGVKVAEITELIQKALENDQRVRKEGGKFGFAESIANQRITAFKMETAPIDTSNIEERAEEIIAEAEPPPEVVSQPVLWTPGTAQIGDGIENSWGDLEDSEKEEEEEEGGIDEAVILDDTKMDTGEVSDIGSQGAPIVLSDSEEEEMIILEPEKNPKKIRAQTSANQKAPSKGQGKRKKKKRTAN
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  EXOSC9 binds to ARE-containing RNAs (By similarity).
What are the official names of this protein?
Exosome complex component RRP45, Autoantigen PM/Scl 1, Exosome component 9, P75 polymyositis-scleroderma overlap syndrome-associated autoantigen, Polymyositis/scleroderma autoantigen 1, Polymyositis/scleroderma autoantigen 75 kDa, PM/Scl-75.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity).
Protein: RL20_CALS4
Sequence: MARVKSGKVTRRRHKKILKLAKGYWGAKSKLFRVANQAVMKSLMYAYIGRKLRKRDFRRLWITRINAAARAYGISYSRFINGLKKAGIEINRKMLSEMAIHDEKAFAELVNIAKQQLNA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: MIAA_LIMRD
Sequence: MNKVIAIVGPTAVGKTALSIKLAHEFDGEVISGDSMQVYRRLDIGTAKVTPEEMGDVPHHLIDICNIEERFSAARFKKLADQKIDEIAQRNHLPIIAGGTGFYLQTLTDNLALGSDQFDQQTLDIRNHWKEVAEEKGAEYVWEQLNKLDPVASARIPKSNTRRVIRALEVIKKTGQLFSNQPHFKATNDFLLIGLTTDRPVLYDRINKRVDLMIQNGLLEEAKWLFDQGGEDLPAGKGIGYHELFPYFRGEISLDEAVEKIKQDSRHYAKRQLTWFRNKADTHWFDILRHPDDINQIKQFINDWLKK
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PALY_DIGLA
Sequence: MAAVVENGHHGNNGFCVKQNDPLNWVAAAEELKGSHLDEVKRMVEEFRKTVVKLGGETLTISQVAAIAARDNEVAVQLAESSRAGVKASSDWVMESMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGNGTESTHTLPHSATRAAMLVRINTLLQGYSGIRFEILETITKFLNHNITPCLPLRGTITASGDLVPLSYIAGLLTGRPNSKAVGPNGESLNAEQAFKLAGANSGLFFELQPKEGLALVNGTAVGSGLASIALYEANILSLLAEVMSAVFAEVMNGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSSYVKAAQKMHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRTATKMIEREINSVNDNPLIDVSRNKALHGGNFQGTPIGVSMDNSRLAIASIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGSEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTVEALDILKLMSSTYLVALCQAIDLRHLEENLRLSVKNTISQVAKRTLTTGVNGELHPSRFCELDLLRVVDREYVFAYVDDPCSATYPLMQKLRQVLVEHALKNGENEKNASTSIFQKIEAFEAELKAVLPKEVESARVALEDGKPAIANRITECRSYPLYKFIREELGTNFLTGEKVMSPGEECDRVFTAMSKGLIVDPLLKCLEGWNGAPLPIC
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KARG_PLOIN
Sequence: MVDAATLEKLEAGFSKLAASDSKSLLKKYLTREVFDALKNKKTSFGSTLLDSIQSGVENLHSGVGIYAPDAEAYVVFADLFDPIIEDYHNGFKKTDKHPPKNWGDVETLGNLDPAGEFVVSTRVRCGRSMEGYPFNPCLTEAQYKEMEEKVSSTLSGLEGELKGTFFPLTGMSKETQQQLIDDHFLFKEGDRFLQAANACRFWPSGRGIYHNENKTFLVWCNEEDHLRLISMQMGGDLKQVYKRLVRGVNDIAKRIPFSHNERLGFLTFCPTNLGTTVRASVHIKLPKLAADKAKLEEVASKYHLQVRGTRGEHTEAEGGVYDISNKRRMGLTEYEAVKEMYDGIAELIKIEKSL
What are the official names of this protein?
Arginine kinase, AK.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.