PharMolix/UniProtQA huggingface dataset:
Protein: CARA_POLNS
Sequence: MSPLLPSFPPAVLALADGSIFPGYSIGAPGETTGEVVFNTALTGYQEIITDPSYSRQIVTLTYPHIGNVGVNAQDAESDRIHAAGLVVKDLPKRVSSFRSEGALDDYLTKAGVLGIAGIDTRKLTRILRDKGAQSGAIVAGKVGDSYETLVSKALELAKAFPGMSGLDLAKVVTTQKVYEWREAEWNLHGADGKPAYGTLDTGKPINKVVAYDFGVKRNILRMLTERGCQLTVVPAQTTAAEVLAMNPDGVFFSNGPGDPGPCDYAIAAAKEIIEKGVPTFGICLGHQIMGLAAGAKTLKMKFGHHGANHPVKDLDTGRVAITSQNHGFAVDANTLPDNIRVTHVSLFDGSLQGLAWKDKPELCFQGHPEASPGPHDIAYLFDRFVELMNAASKKEGE
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: PPCK1_ARATH
Sequence: MTCSQTLGNNNTNKYQICEEIGRGRFGTVSRVYAPATGDFFACKTIDKASLSDDLDRACLDNEPKLMALLSYHPNIVQIHDLIDTDSTLSIFMELVHPSVSIYDRLVSSGTFFEPQTASFAKQILQALSHCHRYGVVHRDIKPENILVDLRNDTVKICDFGSGIWLGEGETTEGVVGTPYYVAPEVLMGYSYGEKVDLWSAGVVLYTMLAGTPPFYGETAEEIFEAVLRGNLRFPTKIFRGVSSMAKDFLRKLICKDASRRFSAEQALRHPWIQRAGETEERFI
What is the function of this protein?
Calcium-independent kinase involved in light-dependent phosphoenolpyruvate carboxylase phosphorylation.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase kinase 1, AtPPCK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: DEF_STRPZ
Sequence: MSAQDKLIKPSHLITMDDIIREGNPTLRAVAKEVSLPLCDEDILLGEKMMQFLKHSQNPVMAEKLGLRAGVGLAAPQIDVSKRIIAVLVPNLPDKEGNPPKEAYSWQEVLYNPKIVSHSVQDAALSDGEGCLSVDRVVEGYVVRHARVTVDYYDKEGQQHRIKLKGYNAIVVQHEIDHINGVLFYDRINAKNPFETKEELLILD
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RS18_SOLUE
Sequence: MAESKGRPGSASQRPTGGDKAIAGQKKQYFRRKKVCRFCVEKIDDINYKDVKMLHAFVAERGKIVPRRISGVCAPHQRRLTDAIKKARNIALLPFAASF
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: PKHO2_MOUSE
Sequence: MEEESIKEGSEKPRGARTADKAGWIKKSSGGLLGLWKDRYLLLCQAQLLVYENEDEQKCVETVELGSYEKCQDLRTLLKRKHHRFILLRSPGNKVSDIKFQAPSGEEKESWIKALNEGINRGKNKAFDEVKVDKTCALEHVTRNRVRGGQRRRPPTRIHLKEVASAASDGLSRLDLDVPDSGPPVFAPLSDISEDQPQEPPRALMPPVKPSPGPETSAVEDSKETPAGERALTPDSASSGANPESQEDAETPAKEDSDVKSLPNSTLSEKLKVSWENPSPEKPSAPESAQLSSSETPEATPRESKKPPAPPPKILSEKMKACMSGVDASGSSQSSEAPETTSPEPTQVSVNGMDDGPESALQAMGIPGPAPEDAAASPALPFSDLPSQFHPRSSSLGDLLRESPQHPRLPKEKLYRAQLEVKVASKQTEKLLNQVLGSEPPPVCAESLLSQAVEQLRQATQVLQEMRDLGELNQETPGLVQKRKELVTLYRRSAP
What are the official names of this protein?
Pleckstrin homology domain-containing family O member 2, PH domain-containing family O member 2, Pleckstrin homology domain-containing family Q member 1, PH domain-containing family Q member 1.
Protein: YIDD_XYLFA
Sequence: MHKAIMHPLILLLKIYKRLISPLLGPHCRFEPSCSEYAMGAIARFGTLRGIWLAARRLARCQPLQPGGYDPVPDNISTQVNPPSHRCTGHHQ
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y4174_GLOVI
Sequence: MALLLFGLAAAAEIGGCFAFWSVLRLGKNPLWLAPGLVSLVVFAWLLTRSEATYAGRAYAAYGGVYIAASLVWLWLVEGTRPDRWDLAGALLCLAGAAVILFADRSP
What are the official names of this protein?
UPF0060 membrane protein glr4174.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSRA_PSESM
Sequence: MTLRSEILVNKNVLPTAEQALPGRETPMTLPETHFVNGNPLLGPFTSNVEFAIFGLGCFWGAERRLWQQEGVVSTVAGYAGGFTPNPTYEEVCSGLTGHTEVVLVVYEPEKISYDSLLKVFWEAHNPTQGMRQGNDIGTQYRSVIYCTTPEQLAAAKASADAFQAELSKAGLGGITTEIEEAPTVYFAETYHQQYLAKNPQGYCGLGGTGVCLPA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: RR4_TETOB
Sequence: MSRYIGPRLRIIRRIGKLRGFTRKKPFRRSFRGRGALQGKVIPPGQHGLTKLFKSRPFDSNESDYLIRLKVKQRLRYNYGITEKQLVKYVRQAKKMKESTGQVLLQLLEMRLDNIVFRLNMAPTICAARQLISHGHIHVNSKKVNIASYMCKPKDVISVSMKQSSLKLVNRNLQEYSQKMSAYKKRLERTLAYVLFQRNISPNMANALEYINQGKVQVNNRKVLLPNYLCHSKDMISVKTDKGIRKFQFSE
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: VSPAF_DABSI
Sequence: MVLIRVLANLLVLQLSYAQKSSELVVGGHPCNIYEHHFLAFMYNSSGFMCSGTLINQQWVLSAAHCDMENMHIYLGLHSFKLPNKDQKKRVAKEKFFCLSSKSYTKWDKDIMLIKLNKPVTYSTHIASLSLPSNPPRVGSVCRIMGWGSITSPKKILPFVPHCANINIVPYTVCRVIYRPLPEQSRTLCAGVSGRRIGSCLGDSGGPLICNGQIQGIVSWGSDPCVNRGAPSIYTKVFDYTDWIHSIIAGNTAATCPS
What is the function of this protein?
Degrades alpha chain of fibrinogen (FGA), and has strong caseinolytic activity.  Cleaves oxidized insulin B-chain at '40-Tyr-|-Leu-41', '48-Phe-|-Phe-49' and '49-Phe-|-Tyr-50', and glucagon at the bonds '62-Tyr-|-Ser-63', 66-Leu-|-Asp-67' and '78-Leu-|-Met-79' bonds.
What are the official names of this protein?
Alpha-fibrinogenase-like, RVAF, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LSM8_SCHPO
Sequence: MSLADFMEQRVQVITNDGRVVLGSLKGFDHTTNLILSDSFERIISMDQDMETIPLGVYLLRGENVAMVGLVNEELDSEIEWTKIRGEAIPDVVH
What is the function of this protein?
Probable component of the spliceosome.
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm8.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTU_FRAP2
Sequence: MAKEKFERSKPHVNVGTIGHVDHGKTTLTAAITKVMAEKNGGSARKFDEIDNAPEEKARGITINTSHVEYESPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRELLDQYDFPGDDTPVIMGSALKAIEGEEQYVEKIVELVAAMDDYIPAPERDTAKPFILPIEDVFSISGRGTVVTGRIERGVINVGDEVEVVGIRPTQKTTVTGVEMFRKLLDKGEAGDNVGILVRGLKRDDVERGQVLCKPGSIKPHTKFEAEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDITGAVELPEGVEMVMPGDNIKMTITLINPIAMDEGLRFAIREGGRTVGAGVVAKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COFH2_METAC
Sequence: MYMKKPAIPDDVIERVQQGKCTKEDALLLLEGNPFELFELANKLRASTVGDVVSYVVNRNIYITNKCVGTCGFCAYRTDEGYILSIEEILKQTEEAREAGAVEVCVQGGYTPEADMEFYLEIIEAIKSGFPDICIHALSPMEVNYAAGLSGMSVEDALRKLKKCGLDSLTGTSAEILSDRVRKIICPGKITTQQWVDTVTAAHRAGISTNSTIMYGHVETLEERLDHVFTIREIQKETGGISELIPMSFLPYNNPIGEKMMASGKFTSTGLEDLQLIAISRIILHTHVNNIQATWVKLGKKLAQFALQCGANDLGGTLMEDQISTASGGSYGEYVSPAEFEWMIKGAGRVPIQRDTLYRKVEPRLPASEGLLPGYVKPKMGSKE
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
What are the official names of this protein?
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase 2, FO synthase subunit 2 2.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofH family.
Protein: ORF3_HEVMG
Sequence: MGSPCALGLFCCCSSCFCLCCPRHRPASRLAAVVGGATAVPAVVSGVTGLILSPSPSPIFIQPTPSLPMSFHNPGLELALDSRPAPLAPLGVTSPSAPPLPPVVDLPQLGLRR
What is the function of this protein?
Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity.  Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway.  Acts also as a viroporin and forms ion conductive pores allowing viral particle release.  Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways.  Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression.  Interacts with host microtubules.
What are the official names of this protein?
Protein ORF3, pORF3.
What is the protein family that this protein belongs to?
Belongs to the hepevirus ORF3 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=The N-terminal region seems to associate with the cytoskeleton probably via one of its hydrophobic regions.
Protein: ATP22_KLULA
Sequence: MFALSKSLRQIKRQTIQYRFISGISKDEVYCIIDTIKSSHEWHKLKQDQKMQAYVAEALTNPTSENVSELMQLKRKMMRTLNENYNLALGYIEEGLPGPIERLKFRSEFLRVVDSEHYAYFSKSLDHIRYCKGLDRATRRKEFYNCIELHRRCNPEVTEGSGILLPDDIHQWFFVFVPPDERMKHYLFLIENNVLISGHYAGLTQERMLKGSEMEYRVASFLHFIEDPEKRHIFDEKFSVMHPFRPMRRIVNLLITKKDMVHIKEYLDVLTTRLENVELRNERIPYDVRKLYFIEFMHTLQHFARCTNYIDMFLETVHSMMDALPKDTPVPFIRKSFVEILNYFQRIGDTETVFKIMSMFNEYPLTEPNTKFTNEMLGRILFSLRQFKDPKLTASYIVIAYKSIKTKKMLNNLGLWCLIFGNGFGRLNKKAIRDAKQPEKFINLNVPESLRFKRAPDSVALNELYIVVFDYYKSKLSPDEYRELVVKCYKYYCDFLKNHVNTYLQWRIDTSILRTMIHRAKFDIKDDRLAYEMLMNFYAMNLNPRFDSKNTPFGLVLYRNEAINQQEFNQVLELMQRCRAPMDHKIIITIVLKFIKSGNIDLAHEWYTRLLKTGYPLRHFKMIEEAKRLNWDIPEPAERYYEECERKNQLEEENFDDIYLQNPAEDSYTNDLIEAAKKIGRIYATSIGARIIPENDKAAMELNQKKNAYGT
What is the function of this protein?
Translation factor specific for subunit 6 of the mitochondrial ATPase.  Required for assembly of the CF(0) component of the ATPase (By similarity).
What are the official names of this protein?
Mitochondrial translation factor ATP22.
What is the protein family that this protein belongs to?
Belongs to the ATP22 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: RL2_LEGPL
Sequence: MALLKSKPTSPGKRGEIRVVHHHIYKGKPHAALVEKLKKTGGRNNQGRITVRHIGGGQRQKYRIIDFKRNKDGILGRVERLEYDPNRTALIALISYKDGEKRYIIAPSNLEVGATIQSGADSPISVGNCLPLKNIPVGTTIHCVEMKPGKGAQMLRSAGCSGQLVAKEGVYATLRLRSGEMRKIHVLCRAVIGEVSNSEHNLRALGKAGAKRWRGIRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGLPTKGYKTRSNKRTDTFIVRGRKKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: HPRK_LISIN
Sequence: MTKSVTVKDLKERLNLELICSETGLERPILTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: KEN_DROYA
Sequence: NMLAHLEDGALNGDTLTPDRKHLLEAQRNRAHSPEMPMHLGPQFVYQWQSNQNAAMSAMPNLQSRLSSLSHISLNLDHPEGRSGSASGSAANLAGSNTHASSVREYRCEYCGKQFGMSWNLKTHLRVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVRHLSGHHNNLLLTKNL
What is the function of this protein?
Probable transcription factor, which is required for terminalia development.
What are the official names of this protein?
Probable transcription factor Ken, Protein Ken and Barbie.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHLB_ZAMFI
Sequence: RRLLRDLNIKINQVIPEGGSVKDLKNLPKAWFNLVPYREVGLMTAMYLEKKFGMPYVSTTPMGVVDMAECIQQIQRSVNTLAPTSSNKKVDYEPYIDEQTRFV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex (By similarity).
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLPX_IDILO
Sequence: MTDQSKGDGDKPLYCTFCGKSQHEVKKLIAGPSVFICDECVELCNDILKEEIHQLSPVPDQDELPVPKAIRKHLDDYVIGQDRAKKVLSVAVYNHYKRLRGSAKQEVELGKSNILLIGPTGSGKTFLAETLARYLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAERGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLNKVIEQRLSTGTGIGFGAEVKSKTQSEEGAIIAKVEPEDLVRYGLIPEFIGRLPVVATLDELDEEALIEILREPKNALTKQYSALFEMEDVELEFREDALRAIAKKAMARKTGARGLRSIVEGVLLGTMYELPSIEGVAKVVVDESVIAGESDPILIYANQQKNKQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TX36A_PHORI
Sequence: GTCAGQDKPCKETCDCCGERGQCVCEGPCICRQGYFWIAAYKLGNCK
What is the function of this protein?
Blocks voltage-gated sodium channels (Nav).  Causes rapid general spastic paralysis and death when injected in mice at dose levels of less than 2 ug per mouse.
What are the official names of this protein?
Delta-ctenitoxin-Pr2d, Delta-CNTX-Pr2d, Neurotoxin PRTx32C1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 03 (Tx2) family. 06 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OLEU_STRAT
Sequence: MRWLITGAAGMLGRELVRRLAENEEDVAALGHDHLDVTRPSAVRAALAEHRPGIVVNCAAYTAVDDAETDEAAAALLNAEAPRLLAEGLRPHRRHGLVHLSTDYVFPGDARTPYAEDHPTAPRSAYGRTKRDGEQAVLTALPTATVLRTAWLYGRTGRSFVRTMIEREARGGAIDVVADQRGQPTWTGDLADRIIAVGRHPGVHGILHATNAGSATWYDLAQEVFRLLDADPGRVRPTTGAAFRRPAPRPAYSVLGHDRWRGTGLAPLRDWRSALREAFPDILAAEHPPTRRGAA
What is the function of this protein?
Involved in the biosynthesis of one of the two 2,6-deoxysugars, dTDP-L-oleandrose, attached to the macrolactone ring oleandolide to produce the aglycone antibiotic oleandomycin (PubMed:10770761).  Probably catalyzes the reduction of dTDP-4-keto-2,6-dideoxy-beta-L-galactose to yield dTDP-L-olivose.
What are the official names of this protein?
Probable dTDP-4,6-dihydroxy-2-methyloxan-3-one 4-ketoreductase.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose reductase family.
Protein: PGLRE_ASPNG
Sequence: MVTSSSVIGLTLWAALVSASPVADPLVTPAPKLEDLEKRATSCTFSGSEGASSASKSKTSCSTIVLSDVAVPSGTTLDLTDLNDGTHVIFEGETHFGYEEWSGPLVSVSGTDITVTGADGAYLNGDGSRWWDGEGSNGGKTKPKFFYAHDLTSSTISGIYIQNSPVQVFSIDGSTYLTMEDITIDNTDGDDGEAANTDGFDIGDSTYITITGANVYNQDDCVAVNSGENIYFSGGVCSGGHGLSIGSVGGRSDNTVKNVTFYDSDIKSSQNGVRIKTIYGDTGSVSEVTYKEITLSDITDYGIVVEQNYDDTSESPTDGITIEDFVLDNVQGSVESSGTNIYIVCGSDSCTDWTWTDVDVTGGKTSSDCENVPDDISC
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.  Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.
What are the official names of this protein?
Endopolygalacturonase E, PGE, Pectinase 4, Pectinase E, Polygalacturonase E, Polygalacturonase IV, PG-IV.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: OPTN_DANRE
Sequence: MNGDISHPRGSGPGNLGSLEETLQQMNTLIKENRDLKEALKQTNLSMKERFEGLSAWKEKQKEERDFLEQRLEEARTRLNTMDVENEALKNQVKELEKSGAECLHTELEALRGQILRIQAEKNDLVAMNSELQLKMGQGSPSNSFIEIRIADDDLKVTKDLSSVPEASAFSMPKAESEEQTVRQLLRSLRAETDEKERLQLTLQEARGRIAELESKLEHADSSAQTSLPSAAETNASTEVKNLEDQLLKLCNELKQAQIKLDEAESMKRNLQDRCKDLEQDLGTLKTQLGDKQKVQAENDCLKVQMESLQAAIKLEQKKTQDEKNNLNQLKDAYTKLFEDYSELQEEKKKRESCVSKDDYDELQTRFATAEKALADKQQKIDEMKMELFQKEKDLETISVFQAQAEIYSSDFYAERAAREKIHEEKERLATQLEYVKKQNSQLQEEMESLGRHSMSEMQRRHVPRGANPQGPTAPNNLPGGRGEWQQQNIPDHACPKCGEVLPDLDSLQIHIMDCII
What is the function of this protein?
Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death.  May act by regulating membrane trafficking and cellular morphogenesis.
What are the official names of this protein?
Optineurin.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Recycling endosome. Cytoplasmic vesicle, autophagosome.
Protein: RADH_FLOCH
Sequence: MSIPKSCEVLVAGGGPAGSYAASALAREGVDVVLLEADKHPRYHIGESMLPSIRPLLRFIDLEETFEKHGFQKKLGAAFKLTAKREGYTDFVAAHGPNGYSWNVVRSESDELLFKHAAKSGALTFQGVKVDSLEFEPYDSDFPSGGKVANPGRPVAARWSAKDGRSGTISFQYLVDATGRAGITSTKYLKNRKFNEGLKNLAIWGYYKGARPWAEGTPRENQPYFEGMRDGAGWCWTIPLHNGTVSVGAVLRSDLFFAKKKSLGEDVTNAMIMAECMKLCPTIKELLEPAELVSDIKQATDYSYSASAYAGPYFRIVGDAGCFIDPFFSSGHHLAMAGALAAAVSIRASMKGDCSEYEASNWHARKVDEGYTLFLLVVMAALKQIRMQEEPVLSDIDDDGFDRAFQFLKPVIQGSGSAEIVKRFTKKEVSEAIDFAVLALDNMAGAGEHANETNGSNGTGETNGDAKTLENITVEDEKVLSGIRILAKVAPSADMKDLEGTAIDGFMPRLEHGHLGLNRV
What is the function of this protein?
Non-heme halogenase; part of the gene cluster that mediates the biosynthesis of radicicol, a resorcylic acid lactone (RAL) that irreversibly inhibits the HSP90 molecular chaperone, an important target for cancer chemotherapy (PubMed:19101477).  The cluster encodes only two apparent post-PKS enzymes, a cytochrome P450 monooxygenase (radP) and a non-heme halogenase (radH) that introduce the epoxide and the chlorine, respectively (PubMed:19101477).  If this cluster includes all the genes required for radicicol biosynthesis, the remaining structural features of radicicol are presumably generated by the PKSs rads1 and rads2 (PubMed:19101477).  The C-2' ketone could arise if the R-PKS rads1 and NR-PKS rads2 each carry out four iterations, in contrast to the five iteration-three iteration split for the hypothemycin PKSs (By similarity).  The origin of the cis 5',6' double bond is not known (By similarity).  The radicicol R-PKS rads1 ER domain may catalyze either double bond isomerization or reduction in the third iteration (By similarity).
What are the official names of this protein?
Flavin-dependent halogenase radH, Non-heme halogenase radH, Radicicol biosynthesis cluster protein radH.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: PANB_HELPS
Sequence: MSMQTAPIKKITLNHLQAKKNQEKIIAITAYDALFAQIFDPLVDVILVGDSLNMSFFNQNDTLNASVGMMLYHTKAVCAGAKIPFIITDMPFGSYKDEKTALKNAIRVYKETQASAIKLEGGKEKAKLVKTLTDEGVIVVGHIGLMPQFVRLDGGYKIKGKNEEQQKKLLEDALSLEEAGAGLLVLEGITTPIAQKITQTIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYLKGKELVQNAIKQYADDVKKGNFPNELESYH
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTF2_CARMO
Sequence: QLTFTPNWGT
What is the function of this protein?
Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).
What are the official names of this protein?
Hypertrehalosaemic factor 2, Hypertrehalosaemic factor II, HRTH-II, HTF-II, Hypertrehalosaemic neuropeptide II.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZUPT_ECOL5
Sequence: MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG
What is the function of this protein?
Mediates zinc uptake.  May also transport other divalent cations.
What are the official names of this protein?
Zinc transporter ZupT.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL11_IDILO
Sequence: MAKKVSAIIKLQVAAGSANPSPPVGPALGQHGVNIMEFCKAFNAQTDSLEKGAPVPVEITVFEDRSFTFITKTPPASFLLKKAAGIKSGSGEPNTKKVGTVTRAQLEEIAKTKEPDLTAADMDAAVRTIAGSARAMGLNVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.