PharMolix/UniProtQA huggingface dataset:
Protein: CS31_ECOLX
Sequence: MTPIKLIFAALSLFPCSNIYANNITTQKFEAILGATRVIYHLDGNGESLRVKNPQISPILIQSKVMDEGSKDNADFIVTPPLFRLDAKRETDIRIVMVNGLYPKDRESLKTLCVRGIPPKQGDLWANNEKEFVGMKLNVSINTCIKLILRPHNLPKLDINSEGQIEWGIRDGNLVAKNKTPYYFTIVNASFNGKALKTPGTLGPYEQKLYTLPSKISVSGLVKWEIIGDLGESSETKKFNI
What is the function of this protein?
This protein is essential for the biogenesis of mature CS3 pili.
What are the official names of this protein?
Chaperone protein CS3-1.
What is the protein family that this protein belongs to?
Belongs to the periplasmic pilus chaperone family.
What are the subcellular locations of this protein?
Periplasm.
Protein: AL3A1_BOVIN
Sequence: NPHYVDKDRDLDIACRRIAWGKFMNSGQTCVAPDYILCDPSIQSQVVEKLKKSLKEFYGEDAKKSRDYGRIINSRHFQRVMGLLEGQKVAYGGTGDATTRYIAPTILTDVDPESPVMQEEVFGPVLPIMCVRSLEEAIQFITQREKPLALYVFSPNDKVIKKMIAETSSGGVTANDVVVHISVHSLPYGGVGDSGMGSYHGRKSFETFSHRRSCLVRPLLNEETLKARYPRARPICPDT
What is the function of this protein?
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable).  They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable).  Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity).  Preferentially oxidizes aromatic aldehyde substrates (By similarity).  Comprises about 50 percent of corneal epithelial soluble proteins (By similarity).  May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
What are the official names of this protein?
Aldehyde dehydrogenase, dimeric NADP-preferring, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1, Corneal 15.8 kDa protein, Corneal protein 54, bCP54, Transparentin.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB2_HALH5
Sequence: MRQTVKEIVAIGIGGAIGTSFRFLLNTWTLTTGYPYGTLIENIVGSFLLGFLTSWFLVIVPKEWLKKGLGVGLCGGFTTMSTLAADSVLLYSHHPFSSLIYVAASLFGGIGFALLGYLLASKIATRRKREVAGS
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
Protein: PAND_SHIB3
Sequence: MIRTMLQGKLHRVKVTHADLHYEGSCAIDQDFLDAAGILENEAIDIWNVTNGKRFSTYAIAAERGSRIISVNGAAAHCASVGDIVIIASFVTMPDEEARTWRPNVAYFEGDNEMKRTAKAIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABD12_CHICK
Sequence: MRKRNESVTVEHERAAAAPAPLDKGCSLRHSLRLPAADTGMKRPLGRRHGLWFRLRRLIIWLLGVYIAIPFLVKLCPAIQAKLVFLNFVRVPYFIDLKRPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAALWKNARGKDQLWFEDALGSSHPVILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGSPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPEALILESPFTNIREEARSHPFSVIYRYFPGFDWFFLDPITTSGIKFANDENVKYISCSLLILHAEDDPVVPFHLGKKLYNIAATSRSFRDYKVQFVPFHTDLGYRHKYIYRSPELPRILREFLGIPEHEHHH
What is the function of this protein?
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity).  Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity).  Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal.  Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways.  Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).
What are the official names of this protein?
Lysophosphatidylserine lipase ABHD12, 2-arachidonoylglycerol hydrolase ABHD12, Abhydrolase domain-containing protein 12, Monoacylglycerol lipase ABHD12, Oxidized phosphatidylserine lipase ABHD12.
What is the protein family that this protein belongs to?
Belongs to the serine esterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: REV_HV1ET
Sequence: MAGRSGDSDEELLKAVRIIKILYQSNPYPTPEGTRQARRNRRRRWRARQRQIHTLSERILSNFLGRPAEPVPLQLPPLERLNLDCSEDSGTSGTQQSQGTTEGVGNP
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: SYP_DEIRA
Sequence: MTKDGGKKDNQGQDKKAQQYGVTPQSVDFNDWYNEVVKKADLADNSPVAGAMVVRPYGSALWENIQRWLDDRFKASGHESLIFPTLIPMNFIMKEADHVEGFAPELFTVNKIGTEELAEPYVMRPTSETIIGHMWSGWLNSYRDLPFLHYQWGSVFRAELRTKAFLRTSEFFWHEGHTAHADEAEARAEVRQQLDLYHEFCRDVLALPVVRGEKTASERFAGAVATYSIEGMMRDGKALQSGTSHYLGQNFSRAFDVKYQTREQKEEFAHTTSWAISSRIIGAIIMTHGDDSGLMMPPRIAPIQVVVIPVGRKDNFDQMVQEGEKLAAELRAQGLRVKVDGRDGVTNGFKYNDWELKGVPVRIELGPRDLESGVLVVKNRHSEDKETLPRAEAVSGMSARLDTIHDFLMKRATDFLLANTAEVDSYDAFQREIEAGHWVRAYHCGEPACEKSIKEDTKATARNVPFDDAEFFAERGEGQCVKCGQPSAYGKRVLFGRQY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  Can inadvertently accommodate and process cysteine.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIS_NATPD
Sequence: MNGRTREYLKGRFGDHYRRASLSPPPAANEREWGYITWGDGGTTMVRHHSYLDVTGGGDLGGFLAGERPRHVYFSAGRYDDPGASSMGQKGWRGSDLVFDLDADHLPGIDPSETSYAAMLEACKGALSRLLDLLVEDFGFEPLAVVFSGGRGYHVHVRRDDVLELDRTARREIVEYVLGEGLDFDDIVSTQAVAGSAGRSSPAQKRTLPDGGWAGRVRTRLTTLFDEVLTMEEAAALDRLREFDGIGEGKAKAALTAARNNREELTKGNVDVHPAVYSIARELFETVVEAESAPIDEPVTTDINRLIRLPGSLHGGTGLEVQHLDRDAIDAFDPLSDAVPETFVGNEIAIYTQEPTTVELRGESFRLSEGVSSVPEYVGVFAMARGYASKAGE
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: Y4XM_SINFN
Sequence: MTRTVAVLRGFGPVFALLFGLQFISMGAMEMNGPFWPIQIKALSPSDSVFGLAGIGVYVCPMLGVSLTSAFWGRMGDRYGNRLMMVRALLGLAITQLLVAFAQDVWTILALRFLQGACAGYIAPAQAYGVEVTGGRDRARLFAWLQVATNVGSLGGAFLGGLILDALPFAAVNLTAGVICAFCAAVAWTSLPVPLGGAGLTKTAKATTVSCAPSTGVSVFGLLALMGLLLASRMVLQVPFSLYMSEVYGSQHWITGLSYGLLALGFVVAAPVWARTFEGREPSFVLGCNVLIAGGCFVATGLAGSTRAIGLFAALYFTWGALLGGTTPVLLSLVSAATRSERQGSVLGLAQTCQQGASVVGIIAGVAATQRFGLKAAFPLVTGLYGLSFLVALGLWLKARQSRR
What are the official names of this protein?
Uncharacterized MFS-type transporter y4xM.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL31B_YERPP
Sequence: MKPNIHPPYRTVVFHDTSADAYFTVGSTIATERTIERDGQTYPYVTLDISSASHPYYTGKQKEFAKEGSTARFHQRFGSFLTKKTN
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: LSPA_LEPIC
Sequence: MKYFEKRFLDVYRPIYLGVIFLGIVLDLVTKFLVILYFQPHRYLEVFGSFFRMTLTFNTGFVFGAFQDNAIPSLIATGVAIVFLIGYRWKNHDLGNPWGWNLVMAGAFGNFLDKFFVKIPGTGFRFGFQPNMGEYIGVVDFLDFDWPDFLLFSRWPAFNVADSCVTIGLTILIFTMKLEEEK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RK18_NEOYE
Sequence: MKLNTKQTRIHKHKRVRKKVQGTSSRPRLCVFRSNKHIYAQIIDDTQGITLVATSSVNLNNKESDNIRPNCDTSRVVGKQLAEQSMKEGIKNVVFDRGGKLYHGRVKALAEAAKEAGMGF
What is the function of this protein?
Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TYSY_SHESM
Sequence: MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGDTNIAYLRDNKVSIWDEWADENGDLGPVYGAQWRSWPTQSGDAIDQIAQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPRPLPTMTILRKPASIFDYQFEDFELTNYDPHPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_LYSSC
Sequence: MNKEQILEAIKAMTVLELNDLVKAIEEEFGVTAAAPVAVVAGGAAAAEEKTEFDVVLASAGAEKIKVIKVVREITGLGLKEAKEVVDNAPKALKEGVSKDEAEEIKTKLEEVGASVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: Y200_PYRAB
Sequence: MLQEILSSALLMLIMIDPSDKILLVSLLREDFHIEDVKSLIIRANIIGFLLLLIFAVAGKIILQDIFHIELDALRVAGGFVLFKIGLEALESGGMVTIKKEKNILALAAVPVATPLIAGPAAITAAITLTAEYGIVVSVTATFIAIVITAVLMLLSLYLMRGINKTALSVTIRIIGLFIMAIGAQMMISGAGGIVLSILKEA
What are the official names of this protein?
UPF0056 membrane protein PYRAB02000.
What is the protein family that this protein belongs to?
Belongs to the UPF0056 (MarC) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MRE11_METMA
Sequence: MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIKDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNVLSRLKVANIPFFGIVGNHESKQSTQWLDLFEEMGLAGRLGKAPKMVGDVAIYGIDSVPKSKIPLFDYSGFEIPESLPENCRKLLVMHQIMQPSPFPDWDCAEVIENLPFKADAVLLGDYHEYEKIKVGESWVTYSGSTERNSASEKEPRSYSIITLSGEGLEISRRTIPTRNFLFITAKVDGEEKPFEQIFSTVNEHLEEIPESVVFLDVSGDSSSVLSFSEIEEYLLSKGALVVKVKDARVKEGIPEEVIKVAFHDPDRAVAEELRRMSLNDGGLIVDEVIRSPDVPRSRVDEETENRLLGLIEAIDFKDPDFMIKIPVSHVSPVDPSSSVSSIESSGSVSPIDSVSTVSPSSPSSSAIIKEPEELKPPGAAEEIENPKPAGVTEFTAAVAAKSETLMPPVRIQRSESLNESLNKIFEKHDVVPESPETAGSIAGSVETAVEDEISKVTPDSGVITAPQSSSPVSFSDNSQTGFSAISPPESIPSPEILKENSEADADEKPVDGKLSEEKPVGVPDKATKTVKQSHRKGKEKSAVPRQYNLGDYL
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
What are the official names of this protein?
DNA double-strand break repair protein Mre11.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
Protein: NEP1_MOUSE
Sequence: MSAASGGFQPRERRFSVQEQDWETTPPKKLRLGAGSKCGGRRLIVVLEGASLETVKVGKTYELLNCDRHKSMLLKNGRDPGEVRPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVEDISDIRELVPSSDPVVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKVTTAFEEVWGVI
What is the function of this protein?
S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position in 18S rRNA.  Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.  Is not able to methylate uridine at this position (By similarity).  Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase NEP1, 18S rRNA (pseudouridine(1248)-N1)-methyltransferase, 18S rRNA Psi1248 methyltransferase, Nucleolar protein EMG1 homolog, Protein C2f, Ribosome biogenesis protein NEP1.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NOP10_METAC
Sequence: MGQKIRKCKNCGRYTLREKCPVCGGVTLPAIPARFSPQDPYGKYRRLAKKG
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: GALA_ONCMY
Sequence: GWTLNSAGYLLGPHGIDGHRTLSDKHGLA
What is the function of this protein?
Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.
What are the official names of this protein?
Galanin.
What is the protein family that this protein belongs to?
Belongs to the galanin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CDC65_HALSA
Sequence: MLHDDGDASVFVNRDLVEPDTIIDEERIVGRDEQLESVVSFLKPTLQGNRPPNMLLYGPAGTGKSLIIGAVTQQIIELCHSKGERFGVVQVNCQPINTLDQAVYELVQTVASDVGIEPGVPETGVSTKRKYRRLYDLINEHYDSVIFILDEIDLLVGRRANDEPAYSKLLYQLSRASNTNDIEGQVSVAALTNDPKFMENIDGRAESSFNPRDIYFPDYDATQLRQILENRRDAFRQDALTDDVLPLVSAFAAQSHGDARKAIDLFRGAGDLADEQGDQTVREDHVRESQDEIDKDRSLKLIAGLTTQKKISLYATAAVAHCSSATRNSVPSPVGFQVYQWVTEEIDADQMTRETYVKYVKELSTYGLVSTARKSRGRGGGMYMDFTFRGDPESMMHRVVDDTRLERVGTESERLHAVVNAQLREFEE
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 5.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: MATK_MOUSE
Sequence: MARRSSRVSWLAFEGWESRDLPRVSPRLFGAWHPAPAAARMPTRWAPGTQCMTKCENSRPKPGELAFRKGDMVTILEACEDKSWYRAKHHGSGQEGLLAAAALRHGEALSTDPKLSLMPWFHGKISGQEAIQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVCFCNLMDMVEHYTKDKGAICTKLVKPRRKQGAKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHGLYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPDGCPGSVHTLMGSCWEAEPARRPPFRKIVEKLGRELRSVGVSAPAGGQEAEGSAPTRSQDP
What is the function of this protein?
Could play a significant role in the signal transduction of hematopoietic cells.  May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site.  It may play an inhibitory role in the control of T-cell proliferation.
What are the official names of this protein?
Megakaryocyte-associated tyrosine-protein kinase, Protein kinase NTK, Tyrosine-protein kinase CTK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
Protein: COX3_COTJA
Sequence: MAHQAHSYHMVDPSPWPIFGAITALLTTSGLIMWFHYNSIALLTAGLLSMLLVMIQWWRDVVRESTFQGHHTPTVQKGLRYGMILFITSEAFFFLGFFWAFFHSSLAPTPELGGQWPPTGIKPLNPLEVPLLNTAILLASGVTVTWAHHSITEGNRKQAIHALTLTILLGFYFTALQAMEYHEASFSIADSVYGSTFFVATGFHGLHVIIGSSFLTICLLRLIKFHFTSNHHFGFEAAAWYWHFVDIIWLFLYMSMYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UPP_MYCCT
Sequence: MAFTEIKHPLIIDKLTRMRKTETSSKDFRENLSEIAQLMVYEIFRDLKLESVDIETPVSKTTGYTINQPVVLVPILRAGIGMLDGIQKLIPTARIAHIGLYRDEETLETHQYFAKTTKDIDKSYVIVVDPMLATGGSACKAIDIVKQWGAKEIKFVCLVAVEPGIKRLQEQHPDVEIYAASKDEKLNEKGYIVPGLGDAGDRIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RNPH_RICCK
Sequence: MRQSGRKSNQLRPISLELSPLVNAEGSCLIKIGKTHVICSATCETTVPPFLRGQNQGWVTAEYGMLPSSTSQRIKREAVLGKQGGRTQEIQRLIGRAMRCVIDLKKLGERQIIIDCDVINADGGTRTAAITGSYIALHLAIRLLMKKSILKVNPLISQIAAISCGIYKGETILDLDYLEDSDAEVDINFVFAGNGNLIEVQGTAEKKPFSEEQFLAMLKLAKVGAAELFKLQNQVLLGS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: FABZ_SHEB9
Sequence: MSNQMNTMDIKEILKYLPHRYPFLLIDRVLDYTPGVSLQAIKNVSINEPFFQGHFPIQPVMPGVLILEAMAQATGLLAFKTMSSDVPPPGVLYYFAGIDNARFRRVVEPGDQIHFDVKMIKERRGIGVFYGEAKVDGEVVCSAEIMCARREISQ
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGB2_HUMAN
Sequence: MSKGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPILPQ
What are the official names of this protein?
Choriogonadotropin subunit beta variant 2.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: KV3A4_MOUSE
Sequence: DIVLTQSPASLAVSLGQRATISCRASESVDNYDINFMNWFQQKPGQPPKLLIYAASNQGSGVPARFSGSGSGTDFSLNIHPMEEDDTAMYFCQQSKEVPYTFGGGTKLEIK
What are the official names of this protein?
Ig kappa chain V-III region 50S10.1.