PharMolix/UniProtQA huggingface dataset:
Protein: PAL1_IPOBA
Sequence: MANQNGFCIKKQQVDPLNWEMAAESLRGSHLDEVKRMVAEFRKPAVKLGGETLTVAQVARIASRDNAVAVELSEEARAGVKASSDWVMDSMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGNATESCHTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKLLNHNITPCLPLRGTITASGDLVPLSYIAGLITGRPNSKAVGPNGETLNAEEALRLSRSGRRIFRVASPRKGLPSLMAPPLVLGMASMVLFEANVLAVLSEVLSAIFAEVMNGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSSYVKAAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRAATKMIEREINSVNDNPLIDVARSKALHGGNFQGTPIGVSMDNSRLALASIGKLLFAQFSELVNDYYNNGLPSNLTAGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISARKTAEAVDVLKLMSSTYLVALCQAIDLRFLEENLRNAVKNAVTQVAKRTLTVGANGELHPARFCEKDLLRVVDREYVFAYADDPCSANYPLMQKLRQALVDHALQNGENEKNTGTSIFLKVAAFEDELKAVLPKEVEAARIAVESGNPAIPNRIKECRSYPLYKFVREGLGTELLTGEKVRSPGEECDKVFTAMCEGSIIDPLLECLKSWDGAPLPIC
What is the function of this protein?
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
What are the official names of this protein?
Phenylalanine ammonia-lyase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS2_ECOK1
Sequence: MPLPDFHVSEPFTLGIELEMQVVNPPGYDLSQDSSMLIDAVKNQITAGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAAADHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRSLTEATLRLLEKIAPSAHKIGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGE
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: TRPB1_SACS2
Sequence: MVKEDEILPKYWYNIIPDLPKPLPPPRDPQGAYFSRIDLLRSILPKEVLRQQFTIERYIKIPEEVRDRYLSIGRPTPLFRAKRLEEYLKTPARIYFKYEGATPTGSHKINTAIPQAYFAKEEGIEHVVTETGAGQWGTAVALAASMYNMKSTIFMVKVSYEQKPMRRSIMQLYGANVYASPTNLTEYGRKILETNPQHPGSLGIAMSEAIEYALKNEFRYLVGSVLDVVLLHQSVIGQETITQLDLLGEDADILIGCVGGGSNFGGFTYPFIGNKKGKRYIAVSSAEIPKFSKGEYKYDFPDSAGLLPLVKMITLGKDYVPPPIYAGGLRYHGVAPTLSLLTKEGIVEWREYNEREIFEAAKIFIENQGIVPAPESAHAIRAVVDEAIEARKNNERKVIVFNLSGHGLLDLSNYESMMKRLNGNG
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain 1.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: PSBZ_SYNP6
Sequence: MVILFQLALLLLVVMSFVLIVGVPVLYATNGDRVQSNRLILVGGLAWTALVVLVGVLNYFVV
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: ARF1_SALBA
Sequence: MGLSFTKLLGRLFSKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVGEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNISSKA
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: EFG_LACLA
Sequence: MAREFSLANTRNIGIMAHVDAGKTTTTERVLYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAEWKGNRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDAQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFYYSLSTLGDRLGANAHPIQIPIGAEDDFIGIIDLVTMKSEIYTNDLGTDIKETVVGSDEFNAELAALDFNAEEYTELANEWREKLIEAIADFDEDIMEKYFAGEEIPEAELKAAIRKATINVDFYPMLAGSAFKNKGVQMMLDAVIDYLPSPLDIPAIQGVNPDTDEEDERPASDEEPFAALAFKIMTDPFVGRLSFFRVYSGTLDAGSYVLNTSKGKRERIGRILQMHANTRKEIQTVYAGDIAAAVGLKNTTTGDSLTDEKAKIILESIEVPEPVIQLMVEPKTKADQDKMGVALQKLAEEDPTFRVETNPETGETVISGMGELHLDVLVDRMKREFKVEANVGAPQVAYRETFRAGTSARGFFKRQSGGKGQYGDVWIEFTPNEEGAGFEFENAIVGGVVPREFVPAVEKGLVETMANGVLAGYPMVDIKAKLYDGSYHDVDSSETAFKVAASLAMKEAAKTAKPAILEPMMKVTITVPEENLGDIMGHVTARRGQVNSMEAHGKSQIVNAFVPLAEMFGYATTLRSSTQGRGTFMMVFDHYSDVPKSVQEEIIAKNGRNAD
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EUTC_ECOLI
Sequence: MDQKQIEEIVRSVMASMGQAAPAPSEAKCATTNCAAPVTSESCALDLGSAEAKAWIGVENPHRADVLTELRRSTVARVCTGRAGPRPRTQALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLCAEAVEALKAQCVANPDVQVVISDGLSTDAITVNYEEILPPLMAGLKQAGLKVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRMATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
What is the function of this protein?
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds (PubMed:19762342).  Ethanolamine ammonia-lyase (EAL) allows bacteria to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.  It is spontaneously inactivated by its substrate and reactivated by EutA (PubMed:15466038).  Directly targeted to the BMC.  May play a role in bacterial microcompartment (BMC) assembly or maintenance (By similarity).
What are the official names of this protein?
Ethanolamine ammonia-lyase small subunit, EAL small subunit, Ethanolamine ammonia-lyase beta subunit, Ethanolamine ammonia-lyase light chain, Ethanolamine deaminase small subunit.
What is the protein family that this protein belongs to?
Belongs to the EutC family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: RUS_ACIF2
Sequence: MYTQNTMKKNWYVTVGAAAALAATVGMGTAMAGTLDTTWKEATLPQVKAMLEKDTGKVSGDTVTYSGKTVHVVAAAVLPGFPFPSFEVHDKKNPTLEIPAGATVDVTFINTNKGFGHSFDITKKGPPYAVMPVIDPIVAGTGFSPVPKDGKFGYTDFTWHPTAGTYYYVCQIPGHAATGMFGKIVVK
What is the function of this protein?
Electron carrier from cytochrome c552 to the A-type oxidase.
What are the official names of this protein?
Rusticyanin.
What are the subcellular locations of this protein?
Periplasm.
Protein: AROQ_BACC7
Sequence: MKKVLLVNGPNLNRLGVREVNVYGKGTLATLEADMKQEAETMGVELECFQSNHEGAIIDRIHEAEDIYEGIILNPGAFTHYSYAIRDAIASISIPVIEVHISNIHQRESFRHESVTAAVCAGQIVGFGFYGYKLALFALMEKLREA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: MATRX_ISFV
Sequence: MKSLKRLIKSNKKKGDKKNVSFMDWDEPPSYSDSRYGCYPSAPLFGVDEMMETLPTLGIQSLKIQYKCSLQVRAETPFTSFNDAARCISLWETDYRGYAGKKPFYRLLMLIATKKLRAAPMSLMDGNRPEYSSMIQGQSIVHHSLGVIPPMMHVPETFTREWNLLTNKGMITAQIWLGITDVVDDLNPLINPALFSDEKEMTLTSQMFGLELKKRNDNTWLISKSY
What is the function of this protein?
Plays a major role in assembly and budding of virion.  Condensates the ribonucleocapsid core during virus assembly.  Shut off cellular transcription by inhibiting mRNA nuclear export through direct interaction with host RAE1-NUP98 complex.  This shutoff presumably inhibit interferon signaling and thus establishment of antiviral state in virus infected cells.  Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (By similarity).
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the vesiculoviruses matrix protein family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein.
Protein: Y9296_DICDI
Sequence: MEINKIIEINNNNNNNNNKIIENNNDNKKIIEINNNNNDNNKIIEINDNNNNNIKDKILKKENKDSILMKPPPIFITPANKDDTITVFHQGHIISIPRKLKINLKSITDCGPDGVMFRAKNEDSKEEVIVKKISVFLMKDDKMARKLLRNLLFQRHFQQHPLVSTFQSVFKRKSSENYLISNKNNRNNVRLPLLQQKGDDDIYFEYLLPEFTLLQMIHNKLLTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDPSAITIDQNQCLKLTEFYFCFPSNCPVDLFFNDYDTSSFIYRAPETIWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNPTAEDLSIVLSKSIFQYMEKIPKSTLTPSVGIKRRFKGASKDQIELLQGMLCWDPRKRMTIDQLLAHKYFSTIHDESMQIKCNEIFNLKYYPDFYKMKSDLVKKSIENEFLTPC
What are the official names of this protein?
Probable serine/threonine-protein kinase kinase DDB_G0280557.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: RF1_PSYWF
Sequence: MKDSLRERLDQMVDRFEEVTALLSDPDTISDNNKFRELSMEHSELSEITALWQRYRQAEIDKKDAQEMINDASDPDMKEMMQEEIDSASRDIEAMEEELNVMMLPKDPNDKVPAFLEIRAGTGGDEAAIFSGDLFRMYERYASSQGWTIEVLSANEGEHGGYKEIISRVSGNDVYGRLKFESGAHRVQRVPETESQGRVHTSACTVAVMPEVEIDDTVELNPADIRMDTFRSSGAGGQHVNTTDSAVRLTHIPTGVVAECQQERSQHKNRAKAMQMLIARIQQAKVQEQVDTADALRRNLVGSGDRSERIRTYNFPQGRMTDHRINLTLYKLDAIMEGDLTELLDALNREHQADLMASIGGGDD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXLB2_CYRSC
Sequence: MQTSMFLTLTGLVLLFVVCYASESEEKEFPKELLSSIFAADSDFKEEERGCFGYKCDYYKGCCSGYVCSPTWKWCVRPGPGRR
What is the function of this protein?
Agglutinates erythrocytes.
What are the official names of this protein?
U5-theraphotoxin-Hs1b 2, U5-TRTX-Hs1b, Lectin SHL-Ib2.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPC1_CHICK
Sequence: MVKEQFRESDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNHHAPLQYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFKAVIGILQMICKTCCRIMLSVEEKKQFLDYLKRPGLTYLQKRGLKKKVSEKCRKKNTCPYCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSTFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDIPLLLMNPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPIHVAKILTFPEKVNKANINFMRKLVRNGPDVHPGANFIQQRHTQMKRFLKYGNREKMAQELKFGDIVERHLIDGDIVLFNRQPSLHKLSIMAHIARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPAILKPVTLWTGKQVFSSILKPSDDCPVKANLRTKGKQYCGKGEDLCYNDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQVEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLHAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLIMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGKDEPLEFKRVLDNIRAVYPCRSEPALSKNELVLTSESIMKKNEFLCCRDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQLEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDPDFARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYSICISKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQSLKEELPKVVVQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTKTSSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADKESTPPRRPLIFDNNEFHIPIVT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Forms the polymerase active center together with the second largest subunit.  A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III.  A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC1, RNA polymerase III subunit C1, DNA-directed RNA polymerase III subunit A.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPB_XYLFT
Sequence: MSDITVANYHAFPDARGHFGRYGGRFVAETLIGPLQELAQAYDAARHDPDFIAAYNKDLKDYVGRPSPIYHAERLSRKVGGAQILLKREDLNHTGAHKINNTIGQALLAARMGKTRIIAETGAGQHGVASATVAARLGLECVVYMGATDIQRQQINVYRMKLLGATVVPVTSGSATLKDALNEAMRDWVTHVGHTFYIIGTVAGPDPYPRMVRDFNAIVGREARAQMIEDYGRLPDAMTACVGGGSNAIGLFHAFLNDASVRIYGAEAAGDGIATGRHAASIVAGRPGVLHGNRTYVVCDDDGQILETHSVSAGLDYPGVGPEHAFLADSGRVQYVGIRDEEALAAFHLLAHTEGILAALESSHAVAHTMTLARDLPKDALVLCNLSGRGDKDVHTIAAREGVRV
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: HBA1_ANAMI
Sequence: MSLTAKDKDTVRAFWAKASGKAAEIGSDALSRMLVVYPQTKTYFSHWKDLSPGSEPVKKHGKSVMGGVADAVMKIEDLNAGLLNLSELHAFTLRVDPANFKILSHNILVVMAIMFPKDFTPEVHVAMDKFLAALSRALAEKYR
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1, Alpha-1-globin, Hemoglobin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PCKA_EMENI
Sequence: MAPGANIHIPPAGPPEPGPLYSDFYQQQIERQRNNNYHSTSLRNMVATSVNRTALHPGGVQPGKGHTELEEELHEHAHIDYDRVAIIANPSVAALYEDALVYETGTAITSSGALTAYSGAKTGRSPSDKRIVKEESSEKEVWWGPVNKPMTPDVWRINRERAVDYLNTRNRIYVIDGFAGWDERYRISVRVVCARAYHALFMRNMLIRPSAEELKHFHPDYVIYNAGSFPANRFTEGMTSATSVAINFAEKEMVILGTEYAGEMKKGVFTILFYEMPVKHNVLTLHSSANEGQNGDVTVFFGLSGTGKTTLSADPKRALIGDDEHCWTDRGVFNIEGGCYAKCIGLSAEKEPDIFNAIRFGSVLENVVFDPISRVVDYDDSTLTENTRCAYPIEYIENAKVPCLSDSHPSNIILLTCDARGVLPPISKLTTEQTMFHFISGYTSKMAGTEDGVTEPQATFSSCFAQPFLALHPMRYARMLADKISQHKANAWLLNTGWVGAGATTGGKRCPLKYTRAILDAIHSGELAKAEYETYDVFNLHVPKSCPGVPDELLNPKNSWTATTSFSDEVNKLAKLFNENFQKYADQATKEVIAAGPVVQ
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP).
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
Protein: GCH4_RUTMC
Sequence: MSAIHLPDTQNSADTRQIIIDKVGIKDITHPITYIDCDGNKIPTIGIFTMTVSLSERVKGTHMSRFIEILNEGPCEFSAHNFDKIIDKVRKRLESDIAHITLNFTFFRRKKAPSSGVESMMDYQVTLYGTLNKDEVQVMMKVVVPVTSLCPCSKSISKYGAHNQRSHITIKAKAAKDKTLHIEDLIDLAERKASCELYAILKRDDEKVVTERAYDNPAFVEDLVRDIAVDLNADDKISYYRLESENFESIHNHSAYALIENQKC
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: DNJC7_HUMAN
Sequence: MAAAAECDVVMAATEPELLDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLKNAQLELKKSKRKDYYKILGVDKNASEDEIKKAYRKRALMHHPDRHSGASAEVQKEEEKKFKEVGEAFTILSDPKKKTRYDSGQDLDEEGMNMGDFDPNNIFKAFFGGPGGFSFEASGPGNFFFQFG
What is the function of this protein?
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor.  Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required.  In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes.  Recruits NR1I3 to the cytoplasm (By similarity).
What are the official names of this protein?
DnaJ homolog subfamily C member 7, Tetratricopeptide repeat protein 2, TPR repeat protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules.
Protein: SLIK1_HUMAN
Sequence: MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD
What is the function of this protein?
It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321).  Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509).
What are the official names of this protein?
SLIT and NTRK-like protein 1, Leucine-rich repeat-containing protein 12.
What is the protein family that this protein belongs to?
Belongs to the SLITRK family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Secreted. Synapse.
Protein: YACG_SHEPC
Sequence: MPLTVKCPICKTPVEWAPQSEFKPFCSERCKLIDLGDWASEKHAIPVKSEFDLDALDEFDLDEDAFFKE
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: DPP8_HUMAN
Sequence: MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
What is the function of this protein?
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749).  Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818).  Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:34019797, PubMed:33731929, PubMed:33731932).  The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity).
What are the official names of this protein?
Dipeptidyl peptidase 8, DP8, Dipeptidyl peptidase IV-related protein 1, DPRP-1, Dipeptidyl peptidase VIII, DPP VIII, Prolyl dipeptidase DPP8.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family. DPPIV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB1_XANOM
Sequence: MVDDSAVVRQVLVNVLNDAADIEVIATAADPLLAIEKMRKQWPDVIVLDVEMPRMDGITFLRKIMSERPTPVVICSTLTEKGARVTMDALAAGAVAVVTKPRLGLKQFLTESADELVATVRSAARANVKRLAARVTAAPLEAEVKHTADVILPAQSGRAMAQTTERIVAIGTSTGGTQALEEVLTALPRVCPGIVIVQHMPEKFTAAFAARLNGLCQIAVKEAANNDRVMPGRALIAPGGKHLLLRRSGAQYFVEVLEGPPVNRHRPSVDVLFRSAARAAGSNALGIIMTGMGDDGAAGLLEMRQAGARTVAQDEQTSIVFGMPKEAIKRGGADRILALGAMAREIVTQLQ
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SODC_ASPFL
Sequence: MVKAVAVRGDSKISGTVTFEQADANAPTTVSWNITGHDANAERAFHVHQFGDNTNGCTSAGPHFNPFGKEHGAPEDENRHVGDLGNFKTDAEGNAVGSKQDKLIKLIGAESVLGRTLVIHAGTDDLGRSEHPESKKTGNAGARPACGVIGIAA
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_METB6
Sequence: MDNQVFSGIFARAREQHPLVHHITNYVTVNDCANITIGAGGAPVMADAREEAGEMTGFAGALVLNIGTLNSGIIESMILAGKVANERKIPIILDPVGAGATRLRTDSTRRLLDELTISIIKGNAGEIGVLAGAEAKVRGVDSAGISGDPVTITRTFARETGITVVMSGATDIISDGNKVLLVDNGHPLMGRISGTGCMASAVTGVIAAVEKDRLIAAATALAAFGLAGERAAAASRGPGSFKPALFDAMAELGPQDLAADARVRSA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RL13_COXBR
Sequence: MATYMANAKTVSPRWLLVNAEGKTLGRLASRIAAILRGKHKAEFTPHVDAGDFVVVINVDKLKVTGNKTQDKQYHHHSGYPGGLKTINFADLQAKKPQRILELAIKGMLPKGPLGRQLYRKLKIYAGDQHPHQAQQPELIDL
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.