PharMolix/UniProtQA huggingface dataset:
Protein: SIX3_ORYLA
Sequence: MVFRAPLDFISASRLLLPHFADAPPVLSRSRSPEHPPAGFLSLALPGLCFSATQIASVCETLEETGDIERLARFLWSLPVNTDGRDSISEHESVQRARAVVAFHTGCYRELYRILETHRFTRASHSKLQAMWLEAHYREAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRGLLREWYLQDPYPNPGKKRELAHATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHHRICPDSACTLSGGDSSERADGDTFLSVTDSDSDLDV
What is the function of this protein?
Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes.  During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon.  Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression.  In addition, Six3 activity is required for the formation of the telencephalon.  During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration.  Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2.  During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm.  In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation.  Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory.  Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner.  Furthermore, during eye development regulates several genes expression.  Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element.  Directly activates RHO transcription, or cooperates with CRX or NRL.  Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures.  During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway.  Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway.
What are the official names of this protein?
Homeobox protein SIX3, Sine oculis homeobox homolog 3.
What is the protein family that this protein belongs to?
Belongs to the SIX/Sine oculis homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIDC_BACTN
Sequence: MDKNTITGLVLIGILLVGFSYLSRPSEEQIAAQKKYYDSIAVVQQQQEALKAKTEAALANENKGAAAAADSSALFFNAMHGTDSKVSIQNSVAEITFTTKGGRVYSAMLKEYKGQDKTNPVVLFDGDDATMSFNFYNKQGAIQTKDYYFEAVNKTDSSVTMRLAADNASYIDFIYTLKPNSYLMNFEIKATGMEGKLASTEYVDIDWTQRARQLEKGFTYENRLSELTYKVKGDNVDNLSAAKDDEKDLGNTAIDWVAFKNQFFSSVFIADQDFNKVSVKSRMEQQGSGYIKDYSAEMSTFFDPSGKQPTEMYFYFGPNHFKTLKALDKGRTEKWELNRLVYLGWPLIRWINQFITINVFDWLSGWGLSMGIVLLILTIMVKVVVYPATWKTYMSSAKMRVLKPKIDEINKKYPKQEDAMKKQQEVMSLYSQYGVSPMGGCLPMLLQFPILMALFMFVPSAIELRQQSFLWADDLSTYDAFITFPFHIPFLGNHLSLFCLLMTVTNILNTKYTMTMQDTGAQPQMAAMKWMMYLMPIMFLFVLNDYPSGLNYYYFVSTLISVGTMILLRKTTDETKLLAILEAKKKDPKQMKKTGFAARLEAMQKQQEQLQQQKQNKR
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCSH_GEOSW
Sequence: MNTPKELRYSEEHEWVRVEGDKVRIGITDFAQSELGDIVFVELPEVGAEITANEPFGSVESVKTVSELYAPISGKVVEVNEELNDNPEYVNESPYEKAWMIVVEPYDMSEIDNLLTAEQYEEMVKEG
What is the function of this protein?
Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
What are the official names of this protein?
Glycine cleavage system H protein, Octanoyl/lipoyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: MIAB_RHIME
Sequence: MTQETALLSTSPEGGDLNVPARKVFVKTYGCQMNVYDSDRMSDALSRDGYVATDVLEDADFVLLNTCHIREKAAEKVYSELGRLRELKKAKALEGREMLIGVAGCVAQAEGDEILRRVPAVDLVIGPQTYHRLPDALKRARAGQRIVETEYAIEDKFVHLPAPDKAKTRARGVTAFLTVQEGCDKFCTFCVVPYTRGSEVSRPVAQIVAEAEKLVEGGVREITLLGQNVNAWHGEGPHGREWSLGDLLRRLGEIDGLARLRYTTSHPRDMDDSLIEAHRSMAKLMPYLHLPVQSGSDRILKAMNRRHTAAEYLALVERIRAAQPDLALSGDFIVGFPGETDQDFEDTLRLVEEVNYAQAFSFKYSTRPGTPGAELKEQVPEDVKAKRLEILQALLVKQQRGFAEACVGREIDLLLEKPGRMPGQLVGRSPWLQPVNVDAKASQIGDIIRVRITKAGPNSLFAEMIGESDARS
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYS2_HUMAN
Sequence: MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN
What is the function of this protein?
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
What are the official names of this protein?
Glycogen [starch] synthase, liver.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 3 family.
Protein: RECA_DEIGD
Sequence: MSKDNPKDFGTPSDSKERLKAIETAMTQIEKAFGKGSIMRLGAESKLDVQAVSTGSLSLDLALGVGGIPRGRITEIYGPESGGKTTLALSVIAQAQRAGGTCAFIDAEHALDPVYARSLGVNTDELLVSQPDNGEQALEIMELLVRSGAIDVVVVDSVAALTPRAEIEGEMGDSLPGLQARLMSQALRKLTAILSKTGTAAIFINQVREKIGVMYGNPETTTGGRALKFYASVRLDVRKIGQPVKLGNDAVGNTVKVKTVKNKVAPPFKEVELTLLYGKGFDQLSDLVTLAADMDIIKKAGSFYSYGEERIGQGKEKAIAYIAERPELEQEIRDRVLAAIKEGRDPIAAVPETPALAE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_MESFL
Sequence: MNKSGIIILNKPKGLTTNHLIQKLKRKLNVKKIGHAGTLDPLATGVVICLINNGTKLSDYFLNENKAYEVTMKLFQATDTYDSDGSIIEEQEPFKIEQEQVEKVIAKFNGLAYEQEPPMYSAIKIDGKKLYEYARENQVVKVNKRLIKINSLSLDKYENNEISMTVYCSKGTYIRSLIVDIAKELNTIAHVTSLNRIESGNFIIKNSVNIENCEESNLIKMFDAIKMADYEIVELDDTLNVEHGKKIEVIAEKNIVFISNKSKELIACYERENGNVFKCKRGGLNI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: WAVH1_ARATH
Sequence: MLNGWRRAFCTSIPKETNQNDVDDDGLVGLRHKSTSRFGFFSTPSTPRSDSGTGTYSLRCRTSTATAVSTTSSLPGTPKLKCKTTTTGETTPRNRSLVSLLTPSSSSISPASFTLLKSKLRFKQSSSNKCGICLQSVKSGQGTAIFTAECSHTFHFPCVTSRAAANHNRLASCPVCGSSLLPEIRNYAKPESQIKPEIKNKSLRVYNDDEALISSPISPAGFHTILESDENEDCEEFTGFSVNTPSPLTAKLLTDRNVDVKLSPESAIVASGKGYETYSVVMKVKSPPFPTARGFARRVPVDLVAVLDVSGRNSGGKLEMLKQTMRIVLSNLREMDRLSIIAFSSSSKRLSPLRRMTANGRRSARRIVDIITVPGSVSGVGIDFSGEGMSVNDALKKAVKVLDDRRQKNPFTAVFVLTDRQAHQVAQLAHSRIPIHTIWLSHAIPEDAFARTINGYLSLSVQDLGLQLGIVSGLGQGEITSVYSLSGRPAWLGTGSIRLGDMYAEEERALLVEIKSPVNNSLTGSRSHKIMTVRSRYVDPTTQELRNPEDRALLIPTPLTVRSSSNPNISRLRNLHVSTRAVAESRRLIERNHYSGAHRLLTSARALLVQHGLSSSDACIRGLDAEIADLNSVKGRHVAASESLESLTPTSAWKAAERLAKVAMVRKHMNRVSDLHGFENARF
What is the function of this protein?
E3 ubiquitin-protein ligase involved in the regulation of root growth.  Acts as positive regulator of root gravitropism.  Possesses E3 protein ligase activity in vitro.
What are the official names of this protein?
E3 ubiquitin-protein ligase WAVH1, Protein WAV3 homolog 1, RING-type E3 ubiquitin transferase WAVH1.
Protein: G6PI_HELPH
Sequence: MLTQLKTYPKLLKHYEEIKEAHMRDWFSKDKERASRYFVQFESLSLDYSKNRLNDTTLKLLFELANDCSLKEKIEAMFKGEKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSVRSVLKRMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMVCTALKRYGHPRLKMHFVSNVDGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVSTNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFRNAPFESNLPVLMGLIGVWYINFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKGETIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFIASLDKKPNAKGHHEILFSNVLAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGALVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKHLIELYKNYNQ
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBZ_TUPAK
Sequence: MTLIFQLTLFAFVGLSFLLVVGVPVVFASPNGWTENKQVVFSGIGFWFLLVFAVGILNSFVI
What is the function of this protein?
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
What are the official names of this protein?
Photosystem II reaction center protein Z, PSII-Z.
What is the protein family that this protein belongs to?
Belongs to the PsbZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. Note=Associated with the photosystem II complex.
Protein: TSIS_WMSV
Sequence: MTLTWQGDPIPEELYKMLSGHSIRSFDDLQRLLQGDSGKEDGAELDLNMTRSHSGGELESLARGKRSLGSLSVAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCEIVAAARAVTRSPGTSQEQRAKTTQSRVTIRTVRVRRPPKGKHRKCKHTHDKTALKETLGA
What are the official names of this protein?
PDGF-related-transforming protein sis, p28sis.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
Protein: QRP_HALAI
Sequence: MAAYCQAQGLDVVLAALLGAINQQPSRQQFQQQQQQQRQPQLQQQQQQQGIQQQPQGLQHQQQQFGLTQQHGQGRRQNIVQPNPASQNNNRMMLDMLLLNQIAQSNRMNTLAFIMAN
What are the official names of this protein?
Glutamine-rich protein.
What are the subcellular locations of this protein?
Secreted.
Protein: CMOA_ECO45
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAEDAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: PEPX_LACDA
Sequence: MKYNQYAYVETSPEKATEELLAINFLPENYSSLSFSELLAVLTGNVLAEATTRQAKDAKLAEFAVDDQTDLAAFLLDTPTAITASQFANVALQLLGYHPNYDYSLTDPLTCGEKHALPAFKDLTSKEELIFAFYRLLNTRSKNGQILLDVMAGKGYFTQFWGEGKFMLFNGKSLPVFDTSQVIREVVYVQSDLDTDGDGKGDLLPVTVFRPVESQDQLKVPALYTASPYFGGIIDNVKTNHNVDENLTDATTWTNPKYVAKPLVKSPAPSGQDVPATELATGQSSYGLNEYLLARGFASVFSGAIGNRHGDGIRITGSPEETISQKEVIEWLTGDRVAYTDRTRRFETKAGWCSGNVGMTGRSYLGTLQIAIATTGVKGLKTVVSEAAISSWYDYYREHGLVIAPSECQGEDMDKLAEVCQSNLWDGGNFTAKKAYEAEQAELLAAQDRATGQYSDFWESRNYRHHADGIKCSWISVHGLNDWNVKPKNVYKIWQKVKQLPVESHLFLHQGPHYNMNNLVSIDFTDLMNLWFVHELLEVENGAYEQWPKVMIQDNLEADKWHAESDWANDLGQASLYSPTADGYLSTVENGTGQLTFTDLGGTEFKKAGISETDWEYQFISGEKKWAKASLRFESEEFLHPTTLVGRPKVQVRVAANKTVGQLSVALVDLGTRQRLTATPKIFARGNQPFGYRFEADSLQEFVPDKATKAKLITKAHMNLQNYQDMKQPSKLEAGQFVDLEFELQPTYYTLPAGAKLCLIIYSTDQGMTKRPLETEDYTVDLAGTALLLYRK
What is the function of this protein?
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Xaa-Pro dipeptidyl-peptidase, X-Pro dipeptidyl-peptidase, X-prolyl-dipeptidyl aminopeptidase, X-PDAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_RHOBA
Sequence: MAGPGLEFENEIADLEEQIASLERNTDRSEEIDSAIRSLRLARVAKLKETYSSLDPWQTVQVARHKNRPYTRDYLNLAFDEFVELHGDKHFGDDRAMLSGFAKLDRFKVMVIGHQKGRTYKERAACHFGCAHPEGYRKAMVKMKMAEKYRLPVICFIDTPGAYPGIGAEERGQAQVIAESMFMMSDLKTPVICVVIGEGGSGGALGIGVGDRVAVLQHAYYSVISPEGCAGILWKSHEHAPKAAAALRFTSDHLLRLGVVDDVLEEPLGGAHRDHHQMATRMKTYLSRQLSELEEMPVDLMLEQRYEKFRKLGVFLEES
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPRT_VIBC1
Sequence: MDIELSYKAKQVMANCIAMAEQAFKRSFPIPSLTFNVRGKAAGKAYLQLNEIRLNPKLFKENPQAFLKEVIPHEVAHLIAYQVYGRVRPHGKEWQGVMEAVFKVPAKTTHSFDVASVQGKTFEYRCGCMTYPLSIRRHNKVLRKEAVYSCQKCRQPLSFTGTQLS
What are the official names of this protein?
Protein SprT.
What is the protein family that this protein belongs to?
Belongs to the SprT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECQ1_CAEBR
Sequence: MSNVLLSKLSSELADLDGQVSQIDQQISQLRRKKAELIQKKQALERKIEMKTNEDSDVVLDRWDQDSFPWSDEANQILKNKFRLEKFRPLQSAAINAVMSKEDAIVILSTGGGKSLCYQLPALLAKGLTLVISPLVSLVEDQIMQLQKLGIDAASLNANTPKDEAKRVEQAITKGSTELRLLYVTPEKLAKSKRMMNQLEKSLGVGYLKLIAIDEVHCCSQWGHDFRTDYSFLNVLKRQFKGVPILGLTATATSNVLDDVKKMLGIPVAIVFRAGFNRANLNYKVLTKPGSEDECVEKIVRTIKRKFSGKTGIIYCLSRNDCEKLAKSLKANGIRAKHYHAYMEPVDRSAAHQKWVSGEIQVIVATVAFGMGIDKPDVRFVIHHSLPKSIENYYQESGRAGRDGLPATCILYYRMSDIFKQSSMIQQEQTGIANLYNMVRYASDTVTCRRVKLAEHFEEAWEPSWCQKQCDVCEKSSNSPGTATEDVSKEAVVVINIIEENLSSAKDGSGRITGNKLLDLLSKKLKGRRTKDFCEKLIVHLLLESYLQEDFHYTVYSVISYVVVGLKWRVYNRKDEIPMTLDNTKKGRAEENNRKRKAAVTSSDEEVDVGDDDDVITL
What is the function of this protein?
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens.  Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity).
What are the official names of this protein?
Putative ATP-dependent DNA helicase Q1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOXP1_BOVIN
Sequence: MMQESGTETKSNGSAIQNGSSGGNHLLECGSLREGRSNGETPAVDVGTADLAHVQQQQQALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLTQGMIPTELQQLWKEVTSAHTTEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKTAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPITPATQGPSVITTTSMHTVGPIRRRYSDKYNVPISSDIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQTSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNGAMEHTNSNESDSSPGRSPLQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME
What is the function of this protein?
Transcriptional repressor.  Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential.  Plays an important role in the specification and differentiation of lung epithelium.  Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2.  Essential transcriptional regulator of B-cell development.  Involved in regulation of cardiac muscle cell proliferation.  Involved in the columnar organization of spinal motor neurons.  Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections.  The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins.  Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3.  Negatively regulates the differentiation of T follicular helper cells T(FH)s.  Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18.  Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis.  Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor.  Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B.  Can negatively regulate androgen receptor signaling (By similarity).  Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity).
What are the official names of this protein?
Forkhead box protein P1.
What are the subcellular locations of this protein?
Nucleus. Note=Not found in the nucleolus.
Protein: ACP_TREDE
Sequence: MDDLFKKIQQLIAAKLEIDEDKVTLDSSFRQDLGADSLDTYELVYALEEDMGIKIPDEKANEFETVRDAYEFIKSQQK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_BRUSU
Sequence: MKRHAVWSSLFVVILAVLIDQGIKYLVESRMFYGQQIDLLPFLALFRTHNEGIAFSMLAWLHDGGLIAITLAVIAFVLYLWWTNAPERVFARYGFALVIGGAIGNLIDRVMHGYVVDYVLFHLPTWSFAVFNLADAFITIGAGLIILEEFLGWRRERISH
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DATIN_MYCTU
Sequence: MEPKRSRLVVCAPEPSHAREFPDVAVFSGGRANASQAERLARAVGRVLADRGVTGGARVRLTMANCADGPTLVQINLQVGDTPLRAQAATAGIDDLRPALIRLDRQIVRASAQWCPRPWPDRPRRRLTTPAEALVTRRKPVVLRRATPLQAIAAMDAMDYDVHLFTDAETGEDAVVYRAGPSGLRLARQHHVFPPGWSRCRAPAGPPVPLIVNSRPTPVLTEAAAVDRAREHGLPFLFFTDQATGRGQLLYSRYDGNLGLITPTGDGVADGLA
What is the function of this protein?
Involved in translation regulation (PubMed:19795912, PubMed:22719925).  Inhibits protein synthesis and decreases bacterial growth when expressed in E. coli (PubMed:22719925).  Can also stimulate macrophages and peripheral blood mononuclear cells (PBMC) to secrete important cytokines that may be significant in granuloma formation and its maintenance.  Increases secretion of IFN-gamma, TNF-alpha, IL-1 beta and IL-8 through human Toll-like receptor 2 (TLR2) signaling pathway (PubMed:23819907).
What are the official names of this protein?
Dormancy associated translation inhibitor, DATIN.
Protein: PURR_VIBCH
Sequence: MATIKDVARLAGVSTTTVSHVINKTRFVAETTQEKVMEAVKQLNYAPSAVARSLKCNTTRTIGMLVTQSTNLFFSEVIDGVESYCYRQGYTLILCNTGGIYEKQRDYIRMLAEKRVDGILVMCSDLTQELQDMLDAHKDIPKVVMDWGPETSHADKIIDNSEEGGYLATKYLTDRGHTEIACLSGHFVKAACQERIQGFRRAMAEAKLTVNEDWILEGNFECDTAVLAADKIIAMDKRPTAVFCFNDTMALGLMSRLQQKGIRIPEDMSVIGYDNIELAEYFSPPLTTVHQPKRRVGKNAFEILLERIKDKEHERRIFEMHPEIVERDTVKDLTKS
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: Y1467_STAAW
Sequence: MDMNFDLYMNGVVEQARNEIESAGYEQLTTAEDVDKVLKQDGTTLVMINSVCGCAGGIARPAASHALHYDVLPDRLVTVFAGQDKEATQRAREYFEGYAPSSPSFALVKDGKITEMIERHQIEGHDVMNVINQLQTLFNKYCEER
What are the official names of this protein?
UPF0403 protein MW1467.
What is the protein family that this protein belongs to?
Belongs to the UPF0403 family.
Protein: POT1_ARATH
Sequence: MNQSPSLIEQGISQQHLKTLSCANVLTLAYQSLGVIYGDLSTSPLYVYKTTFSGKLSLHEDDEEIFGVFSFIFWTFTLIALFKYVFIVLSADDNGEGGTFALYSLLCRYAKLSILPNHQEMDEKLSTYATGSPGETRQSAAVKSFFEKHPKSQKCLLLFVLLGTCMAIGDSVLTPTISVLSAVSGVKLKIPNLHENYVVIIACIILVAIFSVQRYGTHRVAFIFAPISTAWLLSISSIGVYNTIKWNPRIVSALSPVYMYKFLRSTGVEGWVSLGGVVLSITGVETMFADLGHFSSLSIKVAFSFFVYPCLILAYMGEAAFLSKHHEDIQQSFYKAIPEPVFWPVFIVATFAAVVGSQAVISATFSIISQCCALDCFPRVKIIHTSSKIHGQIYIPEVNWMLMCLCLAVTIGLRDTNMMGHAYGLAVTSVMLVTTCLMTLVMTIVWKQRIITVLAFVVFFGSIELLYFSSCVYKVPEGGWIPILLSLTFMAVMYIWNYGTTKKHEFDVENKVSMDRIVSLGPSIGMVRVPGIGLVYSNLVTGVPAVFGHFVTNLPAFHKILVFVCVKSVQVPYVGEEERFVISRVGPKEYGMFRSVVRYGYRDVPREMYDFESRLVSAIVEFVETEPGLEEEEMSSVRRKKEECMEIMEAKEAGVAYILGHSYAKAKQSSSVLKKLAVNVVFAFMSTNCRGTDVVLNVPHTSLLEVGMVYYV
What is the function of this protein?
High-affinity potassium transporter that could play a major role in the uptake of potassium from the rhizosphere.  May act as a low-affinity potassium transporter under high potassium concentrations.  Could also transport rubidium.
What are the official names of this protein?
Potassium transporter 1, AtKT1, AtKUP1, AtPOT1.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNH2_DESHY
Sequence: MKGISRMSIREVSEVLNTEPSEEFLKACAQDERLGIQNLIVRYYKEWEARLVEAERIEALLREEKQLWLNGYLHIAGIDEAGRGPLAGPVVAATCILPAKFNLPGLNDSKKLTESKREKLFQQIKEQAIGYAVGSAEPAEIDGLNILQATKLAMKRAVEGLKVRPHFLLIDALELPSLKIPQKGIIDGDALSASIAAASILAKVSRDHLMGELDKLYPEYGFAKNKGYGTREHLMALRRCGVSPIHRRSFAPVQQQLDIV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.