PharMolix/UniProtQA huggingface dataset:
Protein: AGN1_PAEDI
Sequence: MPDASEIPPPPPGAPGTQFLCLTICGYRRPGMSEEDYRHHMTQVSAPMTQDLMVKYGVKRWTMVHNTSETRALMSRLFDHQMTQLADFDCFSQVVFESVEEYRRMKEDAWYQEHLVGDHEKFADTQRSRMTLGWITELIRDGKVVKGTQ
What is the function of this protein?
Decarboxylase; part of the gene cluster that mediates the biosynthesis of agnestins, dihydroxy-xanthone metabolites (PubMed:30746079).  The pathway begins with the assembly and cyclization of atrochrysone thioester by the non-reducing polyketide synthase Agnpks1 (PubMed:30746079).  The atrochrysone carboxyl ACP thioesterase AgnL7 then breaks the thioester bond and releases the atrochrysone carboxylic acid as the first enzyme-free intermediate (PubMed:30746079).  The decarboxylase AgnL1 then catalyzes the concerted decarboxylation-elimination required to convert atochrysone carboxylic acid into emodin anthrone, which is further oxidized to emodin by the anthrone oxygenase AgnL2 (PubMed:30746079).  Emodin then undergoes reduction catalyzed by the oxidoreductase AgnL4 to yield the dihydroquinone tautomer which is the substrate for reduction by the short chain dehydrogenase AgnL6 reduction to produce hydroxyketone, followed by AgnL8 dehydration and likely spontaneous autoxidation to chrysophanol (PubMed:30746079).  Baeyer-Villiger oxidation by the oxidase AgnL3 leads to monodictyphenone via cleavage of the C-10/C-10a bond of chrysophanol (PubMed:30746079).  Alternative cleavage at the C-4a/C-10 bond of chrysophanol leads also to the formation some cephalone F (PubMed:30746079).  Further conversion to agnestins A and B, requires reduction to dihydro-monodictyphenone, oxidation to agnestin C probably via an epoxide, and rearrangement to either agnestin A or agnestin B directly, although agnestin A or agnestin B can also interconvert (PubMed:30746079).  Within the cluster, AgnR1 is the only unassigned oxidoreductase present which could be involved in this conversion.  However, AgnR1 seems not to be involved in this step, and thus genes involved in the proposed oxidation/reduction may be located elsewhere on the genome (PubMed:30746079).  Further agnestin A derivatives are probably formed by spontaneous decarboxylations, dehydrations and methanolysis reactions (PubMed:30746079).
What are the official names of this protein?
Decarboxylase AgnL1, Agnestins biosynthesis cluster protein L1.
What is the protein family that this protein belongs to?
Belongs to the tpcK family.
Protein: EF1A1_XENLA
Sequence: MTDKAPQKTHLNIVIIGHVDSGKSTTTGHLIYKCGGFDPRALEKVEAAAAQLGKSSFKFAWILDKLKAERERGITIDISLWKFQTNRFTITIIDAPGHRDFIKNMITGTSQADVALLVVSAATGEFEAGVSRNGQTREHALLAYTMGVKQLIVCVNKMDLTDPPYSHKRFDEVVRNVMVYLKKIGYNPATIPFVPVSGWTGENISSPSQKMGWFKGWKVKRKDGFTKGQSLLEVLDALVPPVRPANKPLRLPLQDVYKIGGIGTVPVGKIETGILKPGMTISFAPSGFSAEVKSIEMHHEPLQMAFPGFNIGFNVKNIAVKSLKRGNVAGNSKSDPPTEASSFTAQVIILNHPGFIKAGYSPVIDCHTAHITCQFAELQEKIDRRTGKKLEDNPGLLKSGDAAIITLKPIKPFCVERFFDYPPLGRFAARDLKQTVAVGVVKSVEHKAGAAARRQVQKPVLVK
What is the function of this protein?
This protein is one of two protein components of a 42S RNP particle that is very abundant in previtellogenic oocytes.  A major function served by 42sp50 appears to be the storage of tRNAs for later use in oogenesis and early embryogenesis.  Purified 42S particles can directly transfer aminoacyl tRNA to ribosomes.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha, 42Sp50, Thesaurin A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUPR1_RAT
Sequence: MATLPPTAHTSQQPVNIEDEDGILDEYDQYSLAQSYVVGGGRKGRTKREAAANTNRPSPGGHERKLLTKFQNSERKKAWR
What is the function of this protein?
Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment.  Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:27031958, PubMed:28694771, PubMed:20181828).  Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity).  Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (By similarity).  Negatively regulates apoptosis through interaction with PTMA (By similarity).  Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828).  Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity).  Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (PubMed:28694771, PubMed:27031958).  Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (By similarity).  Coactivator of PAX2 transcription factor activity, both by recruiting the EP300 cofactor to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (By similarity).  Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (By similarity).  Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (By similarity).  Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity).  Also required for LHB expression and ovarian maturation (By similarity).  Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity).
What are the official names of this protein?
Nuclear protein 1, Protein p8.
What is the protein family that this protein belongs to?
Belongs to the NUPR family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
Protein: AROB_SALCH
Sequence: MERITVTLGERSYPITIAAGLFNEPASFLPLKSGDQVMLVTNETLAPLYLDKVRGVLERAGVNVDSVILPDGEQYKSLTVLDTVFTALLKKPHGRDTTLVALGGGVIGDLTGFAAASYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPASVVVDLDCLKTLPARELASGLAEVIKYGIILDADFFTWLEGNLDALLRLDGPAMAYCIRRCCELKAEVVAADEREAGLRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGIVMAARASERLGQFSSADTQRIIALLERAGLPVNGPCEMSAQDYLPHMLRDKKVLAGELRLVLPLAIGKSEVRGGVSHEVVLSAIADCQQA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRM1_LACK1
Sequence: MNNQPCSIVWRRFLTSKVKPAVRIPNENLKANKPTNFTKNFPLNERTKAWERAGEDKESWFKRKYAHVHAKQKSQPQVDLYGKKEAHYSRLKQDILSSKRQQEEHKSKYSRKSVTLGLRPNPLMEYIYGTNSVIAALN
What is the function of this protein?
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of the 2'-O-methylguanosine corresponding to position 2270 in S. cerevisiae 21S mitochondrial large ribosomal RNA, a universally conserved modification in the peptidyl transferase domain of the 21S rRNA.
What are the official names of this protein?
rRNA methyltransferase 1, mitochondrial, 21S rRNA (guanosine-2'O)-methyltransferase, Mitochondrial large ribosomal RNA ribose methylase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MNMA_DEIRA
Sequence: MTAFPAAPDLAPPSRAAQGERVLCAMSGGVDSSVTASLLKEQGYQVIGAMMRFWPDDKRTDTFDSCCSPDAAYEARRVAEQVGVPFYLLDYREPFQRHIVGPFLEEYARGRTPNPCVNCNTKVKFDELVKKAKMLGCRYVATGHYVKRVDNAQGEVEFHRGDDPRKDQTYFLWGTPRDALPYILFPVGELEKPQVREIAAERGLLTAQKPESQNICFVPGKVQDFVAEHLPQAQGYIREIATGEVVGEHLGTQFYTLGQKKGLGLYQSHRVRHVVHLDPDSNTVWVGDYDDCLWTGLKATDANYLLDLAELPTELEVQVRYRTAPVKAHVLHADAEGFELEFAEPQFAVAPGQSAVLYAGSRLLGGGLIADHARELPALT
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIPPO_DROME
Sequence: MSEPEVTSVVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYRPQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQNINNNLIKI
What is the function of this protein?
Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein.  The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam.  Phosphorylates Sav, Wts and Th/DIAP1.  Regulates the level of Th/DIAP1 apoptosis inhibitor.
What are the official names of this protein?
Serine/threonine-protein kinase hippo, Drosophila homolog of MST1 and MST2, STE20-like kinase MST, dMST.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Apical cell membrane. Cytoplasm.
Protein: RF1_ANADE
Sequence: MLSPDVLKKLEAIEQRFEELTQLLSDPAVAGNGDRFRKVAKERASIEQTVTALRAYRKLLDDVAGNEALLGDKDPELRELAKEELAQLRPQVEPAEEQLKLYLVPKDPNDEKDVIVEIRAGAGGDEAGLFAAEVMRMYVRYAERRGWRVELMDTSGGALGGVKEATLTVSGDAVYSSLKYESGVHRVQRVPATEAQGRIHTSTVTVAVMPEAEEIDVQVNPADVEMDVFRSTGSGGQSVNTTDSAVRLTHKPTGIVVKCQQEKSQLKNRTMAMKMLRAKLFEIEQERQRSARDATRKSQVGTGDRSEKIRTYNFPQDRLTDHRVNYTRHNLPAVMDGDVQDVIDACRTFYAAQALREASRGDAGAAERRA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRHO_STRPG
Sequence: MSEKIRVLLYYKYVSIENAQEYAAKHLEFCKSIGLKGRILIADEGINGTVSGDYETTQKYMDWVHSDERFADLWFKIDEENQQAFRKMFVRYKKEIVHLGLEDNNFDSDINPLETTGEYLNPKQFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKDKFMEKRVVVYCTGGVRCEKFSGWMVREGFKDVGQLHGGIATYGKDPEVQGELWDGAMYVFDDRISVPINHVNPTVISKDYFDGTPCERYVNCANPFCNKQIFASEENETKYVRGCSPECRAHERNRYVQENGLSRQEWAERLEAIGESLPEFVGA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: COAD_HELHP
Sequence: MRTLAIYPGTFDPVTNGHLDIIKRSMEIFDNVIVAVAQSSSKRPMFSLQERIDILKLSTQNLVNVQVEGFCTLLADFAKQKGARMIIRGLRAVSDFEYELQIGYANASLNPELETIYFMPTLENAFISSSVVRSIIEHNGAFSHLVPKNAADFIYSLYTKHKRGM
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZUR_BACSU
Sequence: MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSALNDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTKEIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA
What is the function of this protein?
Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes.  Required for the zinc-specific repression of two operons implicated in zinc uptake, yciC and ycdHIyceA.  Also represses the expression of rpmE2, the gene for ribosomal protein L31B, which is expressed only after the end of exponential growth.
What are the official names of this protein?
Zinc-specific metallo-regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CKN3_CONIM
Sequence: MIMRMTLTLFVLVVMTAASASGDALTEAKRIPYCGQTGAECYSWCKEQHLIRCCDFVKYVGMNPPADKCR
What is the function of this protein?
Neurotoxin that induces excitatory symptoms in mice following intracranial administration.  No symptoms are observed after intraperitoneal and intravenous (tail vein) injections (By similarity).
What are the official names of this protein?
Conotoxin Im23.3.
What is the protein family that this protein belongs to?
Belongs to the conotoxin K superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UFM1_CHLIN
Sequence: MSQQTTPAPGVTKVTFKVTLTSDPKLPFRVFSVPEEAPFTAVLKFAAEEFKVPAQTSAIITNDGVGINPQQTAGNVFLKHGSELRLIPRDRVGGSSLAR
What is the function of this protein?
Ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
What are the official names of this protein?
Ubiquitin-fold modifier 1, Protein PR46A.
What is the protein family that this protein belongs to?
Belongs to the UFM1 family.
Protein: FABH_LARHH
Sequence: MPYARILGTGSYLPDTILTNTELAKRVETTDEWIVSRTGIQERRLAAEGQLTSDLAYRAALRAIEAAGIEAASIEMIIVATTTPDMVFPSTAVVVQERLGLAGVPAFDVQAVCAGFMYAFATANAFIRSGQIKRALVIGAETLSRLIDWDDRRTCILFGDGAGAVVLGADEDTGILSTELRADGRYKDILKCDARPSQGVLAGNPFVYMDGQAVFKFAVKALADIAEVTLAKAGKTKADLDWLVPHQANLRIIEATARHLALPMDKVVVTLPNHANTSAASVPLALDAAVRDGRIRRGELLLLEGIGGGFAWGSALLHY
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM2_CLOBM
Sequence: MGNKNVIQKMREKTPLIHCITNYVTINDCANILLAFGASPAMCEAYDEAYDFVSISSALYINLGTLTKEQETAAILASISAKNHNVPVVIDPVGCPAIKRKVEVINRIAEVGRIDIIKGNIGEIKFLAGMDSETRGVDSLDNGENALDACTQLAKKYNCIVAATGKKDFVSDGKRGSVIKNGTEMLTKVTGAGCMLGALCAATCASFEDKLVSTTAAILSMNIAGEKAYEKAQLPGSFRIALIDNIYMISDEEIWERGNVEWK
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 2, 4-methyl-5-beta-hydroxyethylthiazole kinase 2, TH kinase 2, Thz kinase 2.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: NADA_THEVB
Sequence: MFATLAAPQPPLPLDLVAAIQDLKRELNAVILAHYYQDPAIQDVADYIGDSLGLSRQAASTNADVIVFAGVHFMAETAKILNPDKLVLLPDLAAGCSLADSCPADAFAAFKAQYPDHWVISYINCSAEIKALSDIICTSSNAVKIVQQLPPDQPLIFAPDRNLGRYVMAQTGRQMVLWEGSCIVHETFSERRILELKATYPNAQVIAHPECEEAVLRHANFIGSTTALLNYSQTEDCDTFIVVTEPGILHQMQRRNPQKTFIPAPPQDQTCNCNECPFMRLNTLEKLYLCMRDRKPQIELPEDLRLAALKPIQRMLEMS
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_BUCBP
Sequence: MTLYDKEINKNSLLIPMVIEKTSYGERSYDIYSRLLKERIIFLTGTIDDNTANLIVAQMLFLEAENAKQDIYIYINSPGGVITAGMSIYDTMKFIKPNVNTICIGQACSMAALILTAGKKGYRYCLPNSRIMIHQPIGGYNGQASDIEIHAKEIIKVKRKLNELMAFHTSQSINTIEKDTERDCFLSANQAIKYGLIDTILSYRT
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_NITEU
Sequence: MAERRIPLKHEYAQDGKVIYGVDEAGRGPLAGPVYAACVVLDPADVIEGLADSKQLSEKKRISLADQIKQRARAWAIASASVEEIDRLNILQASLLAMQRAVVSLRPISNALVLVDGNHAPRLDCEVQTVIRGDSLVAEISAASILAKTARDIEMLRLHEAYPVYGFDRHKGYPTKAHLEAIRLHGITDIHRRSFAPCVGQSVSGARTTSFINQKEA
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAGH_ECOLI
Sequence: MEITNPILTGFNPDPSLCRQGEDYYIATSTFEWFPGVRIYHSRDLKNWSLVSTPLDRVSMLDMKGNPDSGGIWAPCLSYADGKFWLLYTDVKIVDSPWKNGRNFLVTAPSIEGPWSEPIPMGNGGFDPSLFHDDDGRKYYIYRPWGPRHHSNPHNTIVLQAFDPQTGTLSPERKTLFTGTPLCYTEGAHLYRHAGWYYLMAAEGGTSYEHAVVVLRSKNIDGPYELHPDVTMMTSWHLPENPLQKSGHGSLLQTHTGEWYMAYLTSRPLRLPGVPLLASGGRGYCPLGRETGIARIEWRDGWPYVEGGKHAQLTVKGPQVAEQPAAVPGNWRDDFDASSLDPELQTLRIPFDDTLGSLTARPGFLRLYGNDSLNSTFTQSTVARRWQHFAFRAETRMEFSPVHFQQSAGLTCYYNSKNWSYCFVDYEEGQGRTIKVIQLDHNVPSWPLHEQPIPVPEHAESVWLRVDVDTLVYRYSYSFDGETWHTVPVTYEAWKLSDDYIGGRGFFTGAFVGLHCEDISGDGCYADFDYFTYEPV
What are the official names of this protein?
Putative beta-xylosidase, 1,4-beta-D-xylan xylohydrolase, Xylan 1,4-beta-xylosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 43 family.
Protein: THIM_ECOLC
Sequence: MQVDLLGSAQSAHALHLFHQHSPLVHCMTNDVVQTFTANTLLALGASPAMVIETEEASQFAAIASALLINVGTLTQPRAQAMRAAVEQAKSSQTPWTLDPVAVGALDYRRHFCHELLSFKPAAIRGNASEIMALAGIANGGRGVDTTDAAANAIPAAQTLARETGAIVVVTGEMDYVTDGHRIIGIHGGDPLMTKVVGTGCALSAVVAACCALPGDTLENVASACHWMKQAGERAVARSEGPGSFVPHFLDALWQLTQEVQA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: MLP1_DROME
Sequence: MPFVPVETPKCPACGKSVYAAEERVAGGYKFHKTCFKCSMCNKALDSTNCTEHEKELFCKNCHGRKYGPKGYGFGGGAGCLSTDTGAHLNRE
What is the function of this protein?
Positive regulator of myogenesis.
What are the official names of this protein?
Muscle LIM protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SUMT_SYNY3
Sequence: MVVRLQNGLMGKVYLVGAGPGDPGLITVKGKTLLENAEAVVYDALVSTAILAMVNPQAELIDAGKRRGRHTKLQSETTQLLAQLAEKHAVVVRLKGGDPFIFGRGGEEMEDLVKAGIEVEVVPGITAGIAAPAYAQIPLTHRAYSSSVTFVTGHESAGKYRPEVNWAAIAKGSETIVIYMGVYSLATILPQLMLAGLGEDTPIALIRWGTCPEQQKLVGTFATILAQIEVENFQAPAIVVIGAVVNYPANLRQQLAPILGGVN
What is the function of this protein?
Catalyzes the two successive C-2 and C-7 methylation reactions involved in the conversion of uroporphyrinogen III to precorrin-2 via the intermediate formation of precorrin-1.  It is a step in the biosynthesis of both cobalamin (vitamin B12) and siroheme.
What are the official names of this protein?
Uroporphyrinogen-III C-methyltransferase, Urogen III methylase, S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT, Uroporphyrinogen III methylase, UROM.
What is the protein family that this protein belongs to?
Belongs to the precorrin methyltransferase family.
Protein: NU4LM_TRIVU
Sequence: MTSINLNLTVAFSLALAGVLIYRSHLMSTLLCLEGMMLSLFVMMALLISHFHMFSTSMAPIILLVFSACEAGVGLALLVKTSNNYGNDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y3402_MYCTO
Sequence: MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSFPGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHVSFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRDRIAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFSFHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLRQLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSLRRHAIEARDYYNPPQHRHPYFVTNAELVESTDLAVTADICSRIVSLPVHDHMAPDDVARVVAAVQEAEVRGE
What are the official names of this protein?
Protein MT3510.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family.
Protein: CRHBP_SHEEP
Sequence: MAPTLKLQCHFILVCLLALRGESRYLELREAVDHDPFPHLAGGASPKRELEGEPLYRRALRCVDMLSLQGQFTFTADRRQLHCATFFIAEPEEFITIHYDLVSIDCLRGDILQVFDGWILKGEKFPSSQDHPLPTTERYVDFCDSGLSRRSIRSSQNVAMIFFRVHEPGNGFTITVKTEPNLFPCNIISQTPNGRFTLVMPHQHRNCSFSIIYPVAIKISDLTLGHLNGLQLKKSSAGCGGIGDFVELLGGTGLDPSKMLLLADLCYPLRGPAQMKVGCDHTVLRMVSSGKHINRVTFEYRQLEPYELENPNGNSIQEFCLSTL
What is the function of this protein?
Binds CRF and inactivates it.  May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
What are the official names of this protein?
Corticotropin-releasing factor-binding protein, CRF-BP, CRF-binding protein, Corticotropin-releasing hormone-binding protein, CRH-BP.
What is the protein family that this protein belongs to?
Belongs to the CRF-binding protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: SOLR_CLOAB
Sequence: MNLLNLFTYVIPIAICIILPIFIIVTHFQIKSLNKAVTSFNKGDRSNALEILSKLVKSPIKNVKANAYITRERIYFYSRDFELSLRDLLQAIKLRPKTINDVYSFALSYHILGEPERALKYFLRAVELQPNVGISYENLAWFYYLTGKYDKAIENFEKAISMGSTNSVYRSLGITYAKIGDYKKSEEYLKKALDAEPEKPSTHIYFSYLKRKTNDIKLAKEYALKAIELNKNNFDGYKNLAEVNLAEDDYDGFYKNLEIFLEKINFVTNGEDFNDEVYDKVKDNEKFKELIAKTKVIKFKDLGIEIDDKKILNGKFLV
What is the function of this protein?
Transcriptional repressor of the sol locus (adhE/aad, ctfA, ctfB and adc) genes for butanol and acetone formation.
What are the official names of this protein?
Sol locus transcriptional repressor.