PharMolix/UniProtQA huggingface dataset:
Protein: DAPA_SYNPW
Sequence: MSPAAELSPTPFGRLLTAMVTPFDAEGAVDLALAGRLARHLVDEGSDGLVVCGTTGESPTLSWDEQSQLLEAVRQAVGPGVPVLAGTGSNCTQEAVKATREAAAAGADGALVVTPYYNKPPQEGLEAHFRAIAEAAPELPLMLYNIPGRTGCSMEPATVARLMDCSNIVSFKAASGTTEEVTALRLACGAKLAIYSGDDGLVLPMLSVGAVGVVSVASHLVGRRMRAMVEAYLSGQPAVALGHHEQLIPLFKALFATTNPIPVKAALELSGWPVGSPRSPLLPLDPAMRAALSDTLAALRPT
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTRA_SALTI
Sequence: MPRSTWFKALLLLVALWGPAVQADIGWQPLQETIRKSDKDTRQYQAIRLDNDMVVLLVSDPQAVKSLSALVVPVVSLEDPEAHQGLAHYLEHMCLMGSKKYPQADSLAEYLKRHGGSHNASTAPYRTAFYLEVENDALPGAVDRLADAIAAPLLNKKYAERERNAVNAELTMARTRDGMRMAQVSAETINPAHPGSHFSGGNLETLSDKPGNPVQQALIAFHEKYYSSNLMKAVIYSNKPLPELASIAAATYGRVPNKQIKKPEITVPVITEAQKGIIIHYVPALPRKVLRVEFRIDNNSAQFRSKTDELVSYLIGNRSPGTLSDWLQKQGLVEGISADSDPIVNGNSGVFAISATLTDKGLANRDEVVAAIFSYLNTLREKGIDKRYFDELAHVLDLDFRYPSITRDMDYVEWLADTMIRVPVAHTLDAANIADRYDPAAIKNRLAMMTPQNARIWYISPQEPHNKIAYFVDAPYQVDKISEQTFKNWQQKAQGIALSLPELNPYIPDDFTLIKNDKNYVRPELIVDKADLRVVYAPSRYFASEPKADVSVVLRNPQAMDSARNQVLFALNDYLAGMALDQLSNQAAVGGISFSTNANNGLMVTANGYTQRLPQLFLALLEGYFSYDATEEQLAQAKSWYTQMMDSAEKGKAYEQAIMPVQMISQVPYFSRDERRALLPSITLKEVMAYRNALKTGARPEFLVIGNMSEAQATSLAQDVQKQLAANGSAWCRNKDVVVEKKQSVIFEKAGSSTDSALAAVFVPVGYDEYVSAAYSAMLGQIVQPWFYNQLRTEEQLGYAVFAFPMSVGRQWGMGFLLQSNDKQPSYLWQRYQAFFPDAEAKLRAMKPEEFAQIQQAIITQMRQAPQTLGEEASRLSKDFDRGNMRFDSRDKIIAQIKLLTPQKLADFFHQAVVEPQGMAILSQIAGSQNGKAEYVHPTGWKVWDNVSALQQTLPLMSEKNE
What is the function of this protein?
Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.
What are the official names of this protein?
Protease 3, Pitrilysin, Protease III, Protease pi.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SRSF2_MOUSE
Sequence: MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRPPDSHHSRRGPPPRRYGGGGYGRRSRSPRRRRRSRSRSRSRSRSRSRSRYSRSKSRSRTRSRSRSTSKSRSARRSKSKSSSVSRSRSRSRSRSRSRSPPPVSKRESKSRSRSKSPPKSPEEEGAVSS
What is the function of this protein?
Necessary for the splicing of pre-mRNA.  It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly.  It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA (By similarity).  Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS.  The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity).
What are the official names of this protein?
Serine/arginine-rich splicing factor 2, Protein PR264, Putative myelin regulatory factor 1, MRF-1, Splicing component, 35 kDa, Splicing factor SC35, SC-35, Splicing factor, arginine/serine-rich 2.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear speckle to nucleoplasm.
Protein: 2ABG_RAT
Sequence: MGEDTDTRKINHSFLRDHSYVTEADVISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYESDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH
What is the function of this protein?
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, PP2A subunit B isoform B55-gamma, PP2A subunit B isoform BRgamma, PP2A subunit B isoform PR55-gamma, PP2A subunit B isoform R2-gamma, PP2A subunit B isoform gamma.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B family.
Protein: TU127_LOPOL
Sequence: YYICESCWTCESCAGSTESSCVSACNACDLCPNK
What is the function of this protein?
Acts as a neurotoxin by inhibiting an ion channel.
What are the official names of this protein?
Turripeptide OL127.
What are the subcellular locations of this protein?
Secreted.
Protein: GEX3_CAEEL
Sequence: MAYKDARQVKIAEKLVILNDRAAGMMTRIYNIKKSSGDSKVKPQFLSDKKMEGAIKHIVRKFPVVDCRSNSSTFEYVQEKSTEITKSLSLYYYTFADILDLKDHIMQVLTTMESCQCQLDVTLNYDLTTSYLNLVVHLVTMMILLSRIEDRKAVLGLFNAAYDLQHGQSEASFPRLGQMILDYENPLKKLHEDLGPLNRLIYSALSSVTHTYQRRNKTADSWRTSNVFSLTAAPAQILYAAQTETIACEYLSLDVIDRWIVFCGTVCHSTLLNDDNIRHMWQLALQMNLCLRVFRDETFIVHQEIQAFLESSKEKSKRLQDVKDAFNHASVTAVAVHADRRRFLRSSLRELSLLLRDQPGLLGPKILYVWMALGAGRDEVIWLLRHQVEVPAISKKGSRMVEELVDRQLPELLFYMLELRDLVTKYYAVIQRYYLQYVSSYDSIVVSEEINQANGLTQEEAVLLTDFANEIGNINSDTDLRALRLDWFRFQAWTSAARSHFQLSRHKKLAIYMNTSVFHLKMIDLQDEMLRETSDLSLYCFYPKLAEKHWLNCLQLPAQARYVLSFARLAAHFTSALHDMCPEEKAFITEKALAQCNSVIEETCKQLSYILEKVAEHEFGLAYQMTPSAVAVRVVAQVVQQKGSGKAAAAAAAAARDYFIAGEESYRVDRQALTMPDKLQTTLLEISAALGAHRQIYVADHTFAPRTYLAQSLETKFVELLHGMFWEGQPHASNPKRPSEMLLALQAYMTVLQNLDTAISVDISNTMQTTLLQQTQLVDSKNKDTIAALYTKWYLEVLLRRASSGHMVWSEHLRTMLSSGQEQLSFMPDHYSDPQELRALVQIIGPYGVKLMTERLIWHVASQIMEMSKIVATYKDALQIARSNFDNAEKMKDVLNLLSVEPKDKKTPNATCAADAILQRTIIIGQICLFRDALHDALRHIVESKLPFLQASFDMLYHNLDDVDKVKIGEMSAAMGVTGPVDMSLVNAVRAQNPNIHPQEHYVNSCLLMVAVAICIPRIGMSDLSSYKPSIQASLNNSHCVPMAINTIGSALFHLHEQNDIQSRMKEFLALASSGILRTIHERDNSRQISDDVLRSHTTLYIILEQMVRKNRWLSMDVLETCFPYNLVRTAYQQCYEADAQ
What is the function of this protein?
Rac effector required for tissue morphogenesis, cell migrations and egg laying (PubMed:11877381).  May play a role in egg laying and in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448).  Plays a role in the formation of gap junctions between EA and EP endodermal precursor cells in embryos (PubMed:33238150).
What are the official names of this protein?
Membrane-associated protein gex-3, Gut on exterior protein 3.
What is the protein family that this protein belongs to?
Belongs to the HEM-1/HEM-2 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Enriched at cell boundaries.
Protein: SCBA_STRCO
Sequence: MPEAVVLINSASDANSIEQTALPVPMALVHRTRVQDAFPVSWIPKGGDRFSVTAVLPHDHPFFAPVHGDRHDPLLIAETLRQAAMLVFHAGYGVPVGYHFLMATLDYTCHLDHLGVSGEVAELEVEVACSQLKFRGGQPVQGQVDWAVRRAGRLAATGTATTRFTSPQVYRRMRGDFATPTASVPGTAPVPAARAGRTRDEDVVLSASSQQDTWRLRVDTSHPTLFQRPNDHVPGMLLLEAARQAACLVTGPAPFVPSIGGTRFVRYAEFDSPCWIQATVRPGPAAGLTTVRVTGHQDGSLVFLTTLSGPAFSG
What is the function of this protein?
Involved of the biosynthesis of S. coelicolor butanolide 1 (SCB1), a gamma-butyrolactone that triggers antibiotic production.
What are the official names of this protein?
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase, Signaling molecule synthase ScbA.
What is the protein family that this protein belongs to?
Belongs to the AfsA family.
Protein: GPI14_EMENI
Sequence: MESLFKRPFMVYGLAAGLRTVLLFYGAWQDAHSAVKYTDIDYMVFTDASRYVSQGDSPYARDTYRYTPLLAWMLLPTTWAIPGFFSFGKALFALSDVVAGWLVAKSLTLTHGMSAERALKYASFWLLNPMVANISTRGSSEGLLGVLVVALLWAVLNRRIYLGGVLLGIGVHFKIYPFIYGMSILWWLDEKEFTTNKAQSESREVKPKFKDTPVGIFISQILSFITPCRIRLTLISLLTFVALNAAMYLHYGTPFLQHTYLHHLTRIDHRHNFSPYSTLLYLTAASSAGAVGHDAGGPSGSFESLAFIPQLLISVVVIPLVLGKKDLPGTMLAQTFAFVTFNKVCTSQYFLWYLIFLPFYLPTSSLLRNPRLGIAVAALWILGQALWLQQGYLLEFLGISSFLPGLFLASLGFFAVNAWILGVIVADVGGLNLESGNEKRRVK
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.  Required for cell wall integrity (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 1, GPI mannosyltransferase I, GPI-MT-I, Glycosylphosphatidylinositol-anchor biosynthesis protein 14.
What is the protein family that this protein belongs to?
Belongs to the PIGM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: Y029_BORBZ
Sequence: MLSKIFVDADSCNFKIIKFLQKFILHNKSKLIVVSNKFFSLEITENVALEVVDNVDSFILNLADRYSLVITRDIFFAKLLLDLGVKVMNDEGRIFDINNINYLYFRSKINFNLKIKIKKYYDEDFNKSRYEKFITNFYSLFFS
What are the official names of this protein?
UPF0178 protein BbuZS7_0029.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: NDK_YERPG
Sequence: MALERTFSIIKPNAVANNDIGAIYARFERAGFKIIAAKMLHLTKEQAEGFYAEHKGRPFFDGLVEFMTSGPIMVQVLEGENAVQRHRDIMGATNPDNALAGTLRADFSDSFTANAVHGSDAVESAQREIAYFFAADEIFPRS
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FETP_HAHCH
Sequence: MARMVFCKKYQQELEGLALPPMPGARGKELFETVSKKAWQEWLQHQTMLINEKRLNLMDPDARTYLTEQMEKFLNNENFDAAEGFVPKD
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: MSMK_STRMU
Sequence: MVELNLNHIYKKYPNSSHYSVEDFDLDIKNKEFIVFVGPSGCGKSTTLRMVAGLEDITKGELKIDGEVVNDKAPKDRDIAMVFQNYALYPHMSVYDNMAFGLKLRHYSKEAIDKRVKEAAQILGLTEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMDEPLSNLDAKLRVSMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSSTKNEDGSGTIGRVEQVGTPQELYNRPANKFVAGFIGSPAMNFFDVTIKDGHLVSKDGLTIAVTEGQLKMLESKGFKNKNLIFGIRPEDISSSLLVQETYPDATVDAEVVVSELLGSETMLYLKLGQTEFAARVDARDFHEPGEKVSLTFNVAKGHFFDAETEAAIR
What is the function of this protein?
Involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose.  Probably responsible for energy coupling to the transport system.
What are the official names of this protein?
Multiple sugar-binding transport ATP-binding protein MsmK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AGLB_THENE
Sequence: MYPIPSWVYDSVVYQIFPDRFFIGKGKTVEDKKDLYLKRGGTIEKWGVPPRKLPGAQHVKVFYGGDLWGIAEKIDYLEELGVNAVYLTPIFLSDTNHKYDTIDYFKIDPQFGGKRAFVHLLKVLHSRNIKLILDGVFNHVGSQHPWFKKARKKDPEYVNRFFLYRDRHRSWFDVGSLPELNVEVEEVREYILKVVQHYLEVGVDGWRLDCGHDLGPLVNLWINMKVKEFSSEKYLVSEIWTYPAGWEMVDGLMNYNFRSLVLSYVNGETDSIGTELERAYRETKNIFGCWNMLDSHDTPRLATTVPVKDLRKLAIVLQFTYPGVPLVYYGTEIGLTGGEDPECRATMEWNREKWDMELFEFYKKMIRFRRTDPGLRFGEFILLKEKPLAFMRKAPHPLQDTIVVVNPEEEKNVVLSLPDGKIMNATPLFDIFTGEKFHVDGGVVKVPVGRRSFRILKPIDLRVGRYRLYKRV
What is the function of this protein?
Is able to efficiently hydrolyze alpha-, beta-, and gamma-cyclomaltodextrins and linear maltooligosaccharides, to glucose and maltose, by decycling cyclodextrins and liberating glucose from the reducing end of the molecules.  Shows a very weak activity on starch and pullulan.  Cannot hydrolyze maltose or disaccharides with various types of alpha-links.  Is not active against beta-glycosidic bonds of poly-, oligo-, and disaccharides.
What are the official names of this protein?
Cyclomaltodextrinase, Maltodextrin glucosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: RN152_AILME
Sequence: METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGITKLPPGFSVAQLPDDPEVLAVIAIPHASEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTVPAEQRPLQGGAPQEAVEEEPDRRGVAKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG
What is the function of this protein?
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation.  Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability.  Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.  Induces apoptosis when overexpressed.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF152, RING finger protein 152, RING-type E3 ubiquitin transferase RNF152.
What is the protein family that this protein belongs to?
Belongs to the RNF152 family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass membrane protein.
Protein: PYRC_GEOSW
Sequence: MAIILKNGKSFNKDGVIERTELKIENGFITAIGSKLHSEEADEVIDVQGKLISAGFIDLHVHLREPGGEAKETIATGTLAAAKGGFTTVAAMPNTRPVPDTKEQMEWLCKRIRETAYVHVLPYAAITVGQQGTELTDFAALKEAGAFAFTDDGVGVQSAGMMYEAMKRAAALDMAIVAHCEDNTLANRGVVHDGEFAHRYGLYGIPSVCESVHIARDVLLAEATGCHYHVCHISTKESVRVVRDAKRAGIRVTAEVTPHHLLLCDEDIPGPDANYKMNPPLRSKEDREALIEGLLDGTIDFIATDHAPHTEAEKQKGINAAPFGIVGLETAFPLLYTHLVETNILTLKQLIDLLTVKPAECFGLPLGKLAVGERADITIIDLETEEAIDPQTFVSRGKNTPFAGWKCKGWPVMTFVGGKLVWQKGRE
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: YSNF1_PLAF7
Sequence: MKFFKGKKDKTLDEAYDTLEKSVKGIDENIEKYNKELNVIKQKIEEEKKKNPINQHIINSLRNKAANIIQKKKVYENNKESTMGIQFNIDQIKYANDNVQLSIDTYKALKNTSKVLKKNIKKVNINKIEKLQDDLFDYIEDTKEIGNILSSSYDIPLNLDEQEIDAELALIEDSILDENVEQDNIASYIEDDKKEEDKNLLQQIPVEEKNFDAIQQKTKKETYFAQKES
What are the official names of this protein?
Putative vacuolar protein sorting-associated protein 60.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
Protein: NU1M_DROSU
Sequence: MEFILSLIGSLLLIICVLVSVAFLTLLERKVLGYIQIRKGPNKVGLMGIPQPFCDAIKLFTKEQTYPLLSNYLSYYISPIFSLFLSLFVWMCMPFFVKLYSFNLGGLFFLCCTSLGVYTVMVAGWSSNSNYALLGGLRAVAQTISYEVSLALILLSFVFLIGSYNMVYFFYYQIYVWFLIILFPMALVWLTISLAETNRTPFDFAEGESELVSGFNVEYSSGGFALIFMAEYASILFMSMLFCVIFLGCDVFNLLFYVKLTFISFIFIWARGTLPRFRYDKLMYLAWKCFLSFSLNYLLFFIGFKILLFSLL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MK04_HUMAN
Sequence: MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
What is the function of this protein?
Atypical MAPK protein.  Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5.  The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4.  May promote entry in the cell cycle (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase 4, MAP kinase 4, MAPK 4, Extracellular signal-regulated kinase 4, ERK-4, MAP kinase isoform p63, p63-MAPK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.
Protein: LEUC_SHEB8
Sequence: MTNAKTLYQKVWDAHIVAAPEGEAPVIYVDRHLVHEVTSPQAFSGLKVAGRKLRAPEKTFATMDHNTSTRSASLDALSPMARTQVETLAQNCKDFGVRLYDIHHPNQGIVHVMGPELGITLPGTVIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLRQLKAKTMKIEVRGHVTDGVTAKDIVLAIIGKIGMDGGTGYVVEFCGEAIEALSMEGRMTVCNMAIEMGAKAGMVAPDQTTFDYLAGREFAPKGEDWAEAVAYWKAIKTDDGAVFDAIVELDAADIAPQLTWGTNPGQVVAIDGKVPDPINEANPSTRASMEKALEYIGLSAGTPMTDISINKVFIGSCTNSRIEDLRSAAVHAKGRKVASGVTAIVVPGSGQVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNDDRLEAGDRCASTSNRNFEGRQGRGSRTHLVSPAMAAAAAVAGHFVDIRKPY
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: SYGA_STRS2
Sequence: MSKKLTFQEIILTLQQFWNEQGCLLMQAYDTEKGAGTMSPYTFLRAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLERLGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATGPVTAEVTYGLERLASYIQEVDSVYDIEWADGVKYGEIFIQPEYEHSKYSFEVSDQDMLLENFTKFEKEAERALEEGLVHPAFDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVAKTFVAERKKLGFPLLDEATRAELLKEDAE
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEXA_VIBVY
Sequence: MKPLTPRQQQVFDLIKSKIEVTGMPPTRAEIARELGFRSANAAEEHLKALARKQVIEIVPGASRGIRILLEEEAANDEPGLPLIGRVAAGEPILAQEHVEMHYQVDPSMFRPQADFLLRVHGESMKDIGIMDGDLLAVHKTQDVRNGQVVVARVEDDVTVKRLERKGSTVLLHAENEEFAPIEVDLTSQQLTIEGIAVGIIRNTDWM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: PELO_THEAC
Sequence: MRILEEDLKNSTYRIRIESLDDLWYLRNILSEGDEVSAITFRRVEESADVQRSRERERIPITIRLKVEKIEFQDFDNRLRILGTVIEGPEDTKGKHQSITVTVDSEISITKEWDDQHIDLLKEATDEKYVTVYTAVAMDEDEAQIFLIHPYGIQQVGTVYSGRSGKYAEGNYSEASYFDQIVNALKNYSNSIIILGPGFARDRFARYCAQRGVNVIGSFPANRTDSGAVYEFITSADGAKLLSNERIARDKEIVDEFLVAVKKDMGVYGRDQTESALQMGALSDLIITDEMFRTEDGRRSLSIAQTVGTRIHIVSVSNDPGQIVKKFGGFAGILRYRVQ
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog, Cell division protein pelota-related protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ST7_RABIT
Sequence: MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAMIDIFCSAEFRDWNCESIFMRVEDDLEMPPAPQSQHFQK
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYY_HYDCU
Sequence: MMKTVEEQMAVIQRGAEEILVEKELIEKLKKGKPLKIKAGFDPTAPDLHLGHTVLINKLRQFQDLGHEILFLIGDFTAMIGDPTGKSATRPPLSEEDVLKNAETYKEQVFKILDPAKTKVVFNSEWMSKLSAADMIKLAGTTTVARMLERNDFGERYQSNTPIAIHEFLYPLVQGYDSVALDSDIELGGTDQKFNLLMGRTLQQHYGKEAQCTLTMPILEGLDGVQKMSKSLNNYIGIKDAPNDMFGKVMSVSDELMWRYFELLSFESLETIAGYKDAVANGENPRNIKIKLALELIERFHDKESAEAALKDFETRFSKNAIPDEMPEFTFNEVMPLANLLKEAGLVSSTSDGHRMVKQGAVKLNGEKVTDSRAPVENCEQQVYQVGKRKFARITVAA
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.