PharMolix/UniProtQA huggingface dataset:
Protein: SYGB_SHIBS
Sequence: MSEKTFLVEIGTEELPPKALRSLVESFAANFTVELDNAGLAHGTVQWFAAPRRLALKVANLAEAQPDREIEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLTTDKGEWLLYRAHVKGESTEALLPNMVATSLAKLPIPKLMRWGASDVHFVRPVHTVTLLLGDKVIPATILGIQSDRVIRGHRFMGEPEFTIDNADQYPEILRERGKVIADYEERKAKIKADAEEAARKIGGNADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPAEALVYTMKGDQKYFPVYANDGKLLPNFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFNTDRKKRLEDNLPRLQTVLFQQQLGTLRDKTDRIQALAGWIAEQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYACHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLNLDLQTLTEEAVRLYGDKLTNANVVDDVIDFMLGRFRAWYQDEGYTVDTIQAVLARRPTRPADFDARMKAVSHFRTLDAAAALAAANKRVSNILAKSDEVLSDRVNASTLKEPEEIKLAMQVVVLRDKLEPYFAEGRYQDALVELAELREPVDAFFDKVMVMVDDKELRLNRLTMLEKLRELFLRVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXX_HYPBU
Sequence: MQLSRVRSVLLDVFALAKVKQTLLLLFTMYTAYIVGGGLGKPYERHLVVLTLGFITIAAVTALNMYFDRDIDALMERTRDRPLPAGRLDPLKVFIATVAATIVSVILAWRIINPHFALAIVIGFLFDIVAYTYLLKRRTPLSIIAGAVAGGAPALGGWAAAAGRIDVNALLFSLIVATWVPSHIWFLATYYRDDYRRANVPMLPVVADTPIAVASGIGLGSLVMGYSIVGLWVNNVIGTVSLIVGVIAAIAIFHLAVKYAELGGDPNYSRTAFKKTNMMLGLVFLVMMLEKVVSYIIS
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIUH_SOYBN
Sequence: MMEPPQTRLMINVFIVSFLALLVNLVVGVLGADNYSRDDFPLDFVFGSGTSAYQVEGAANKDGRTPSIWDTFAYAGYAHGENGDVACDGYHKYKEDVQLMLETGLDAYRFSISWSRLLPNGRGPVNPKGLQYSNNLINELISNGIQPHATLYNFDLPQVLEDEYGGWISRDIIRDFTYYAEVEFREFGDRVLYWTTVNEPNVFALGGYDQGNSPPRRCSPPFCATNDTMGNSTYEPYLAVHHILLSHSSAARLYWRKYRDKQHGFVGISIYTFGIFPQTNTEKDRVASQRARDFFVGWIMEPLQYGDYPISMKTNAGERIPAFTNHESKQVKGSFDFIGVIHYTNLNVSDNSDALKNQLRDFTADMAANIFGEDLFSNEEYLITPWGLRQELNKFKLLYGNPPIFIHENGQRTASNSSLQDVDKGEILHGYIGSVLDALRDASNIKGYFRMAFPGFVRVARWIQVSFGLYYVDRDDPQLKKIPKLFCKNGTTGFLKGRRTSILDLFELEQDPITCSKSPIIFSKISKWVLASLLFLIQHKIKFMWREPLPGQIPLKLVMF
What is the function of this protein?
Involved in the conversion of hydroxyisourate to ureides such as allantoin, the major form of nitrogen transport in legumes.
What are the official names of this protein?
Hydroxyisourate hydrolase, HIU hydrolase, HIUHase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass type I membrane protein.
Protein: TAP25_BPML5
Sequence: MTNVFTIDAFREEVKKKYAPVLIGLSDDVTVELKPLLKLGQKAREAVVEVFKEFADIPDLEEDDDDELVDEYSLQVCDIIAKAFRLIATKPKKLIAALDEEPDPRIRAELYAAVLNTWKRETQLGGSRALAELIDKFGGAILADLLQYYRVDLRDLFRDEDPLSPRFVLSLVLCLPKDGAFYAERRGGQQYRGWTEDRYALADIYDAIQAGNHILLLANRDPKKPKPKAPKSYPRPDDLEKTTPKPGSFAAMVVRAKKAARERREREEESAE
What is the function of this protein?
Promotes tail assembly by creating a scaffold for the tail tube proteins.  The tail assembly proteins Gp24 and Gp25 would wrap the linear tape measure protein to create a tail assembly scaffold.  It would allow polymerization of tail tube protein during which Gp24 and Gp25 are released and therefore are absent from the mature virion.  The tail assembly protein Gp25 is produced by a rare -1 ribosomal frameshift.  The ratio Gp24/Gp25 is important for proper tail assembly.
What are the official names of this protein?
Tail assembly protein Gp25, Gene 25 protein, Gp25.
What is the protein family that this protein belongs to?
Belongs to the L5likevirus tail assembly protein family.
Protein: HBB_MACMU
Sequence: VHLTPEEKNAVTTLWGKVNVDEVGGEALGRLLLVYPWTQRFFESFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLNHLDNLKGTFAQLSELHCDKLHVDPENFKLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: APT_PSEA6
Sequence: MPAAYIKSVIKTVPDYPKPGILFRDVTSILEDHKAYTTSIELLVKEFAPYNFDKVAGTEARGFLFGAPLAIELGIGFIPVRKPNKLPRKVISESYDLEYGTDCLEIHEDAVKPGEKVLMLDDLLATGGTMIATANLIRRLGGIVEHAGFVISLPDLGGEAKLQEIGVQSHSICEFEGE
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFCS_METAR
Sequence: MAEDEIWTEKYRPRRLEDVIGHQQITRRLISYVKSGNLPHLLFSGPPGVGKTACAVALARELYGETWHSNFIELNASDERGIDVVRNNIKNFARTAPLGEAKFKIIFLDEADALTSDAQSALRRTMERYAATCRFIISCNYSSKIIEPIQSRCAVYRFGPLNATDITTGITRIAKNEGLKIEKDGMDALIYVARGDMRRAINALQSAATIAKDITADVIYQTTSTAKPKEIEDMLKLALNGQFMDSRNKLDELLITYGLSGTDIIDQIYRSMFELGLDEDVLVALVDRIGEADFRLTEGASERIQIEALLAHFKMQGAARSK
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C small subunit, RFC small subunit, Clamp loader small subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: GBG1_MOUSE
Sequence: MPVINIEDLTEKDKLKMEVDQLKKEVTLERMMVSKCCEEVRDYIEERSGEDPLVKGIPEDKNPFKELKGGCVIS
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
What are the official names of this protein?
Guanine nucleotide-binding protein G(T) subunit gamma-T1, Transducin gamma chain.
What is the protein family that this protein belongs to?
Belongs to the G protein gamma family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: LEUD_METJA
Sequence: MRSIIKGRVWKFGNNVDTDAILPARYLVYTKPEELAQFVMTGADPDFPKKVKPGDIIVGGKNFGCGSSREHAPLGLKGAGISCVIAESFARIFYRNAINVGLPLIECKGISEKVNEGDELEVNLETGEIKNLTTGEVLKGQKLPEFMMEILEAGGLMPYLKKKMAESQ
What is the function of this protein?
Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions.  Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis.  Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis.  Also displays malease activity, i. e.  catalyzes the hydration of maleate to form (R)-malate.
What are the official names of this protein?
Isopropylmalate/citramalate isomerase small subunit, (R)-2-methylmalate dehydratase, (R)-citramalate dehydratase, 3-isopropylmalate dehydratase, Alpha-isopropylmalate dehydratase, Citraconate hydratase, Isopropylmalate isomerase, IPMI, Maleate hydratase, Malease.
What is the protein family that this protein belongs to?
Belongs to the LeuD family.
Protein: NPIIA_TRIRU
Sequence: MQFTALLAALGAPLALAASIPAAAHNHTMIDVQLAATGNSMIKATITNTGDRTLNLLKFNTIMDEHPTRKVMVYQDGAEVQFTGMLPRYKMSDLTPEYFVNLGPKASVEHSFDLAATHDLSRGGKITVKAHGMVPTAEENATTITGHTLYESNELTMDVDGKQAAAVEQAMGGDDSTGVIDKRSNIVTSSCRGSQLRVLQTALSNASRLSRAAASAAQRNPSKMREYFKTADKPHRPEGASRFLSVARESSSGSTGRTTYYCNDNRGGCHPGVLAYTLPSRNQVFNCPSYYQLPALNNRCHGQDQATTTLHELTHNPAVVTPFCEDLGYGYQRVSALPASKAIQNADTYSLFANAIYLGC
What is the function of this protein?
Probable secreted metalloprotease that shows high activities on basic nuclear substrates such as histone and protamine (By similarity).  May be involved in virulence.
What are the official names of this protein?
Probable neutral protease 2 homolog A, Deuterolysin A.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LCAP_RAT
Sequence: METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEVEYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGTCSVPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISSVTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVINLTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSLDGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL
What is the function of this protein?
Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids.  Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy.  May be involved in the inactivation of neuronal peptides in the brain.  Cleaves Met-enkephalin and dynorphin.  Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity).
What are the official names of this protein?
Leucyl-cystinyl aminopeptidase, Cystinyl aminopeptidase, GP160, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, Oxytocinase, OTase, Placental leucine aminopeptidase, P-LAP, Vesicle protein of 165 kDa, Vp165.
What is the protein family that this protein belongs to?
Belongs to the peptidase M1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Endomembrane system; Single-pass type II membrane protein. Note=Localized mainly in intracellular vesicles together with GLUT4. Relocalizes to the plasma membrane in response to insulin. The dileucine internalization motif and/or the interaction with tankyrases may be involved in intracellular sequestration.
Protein: VGB_MYCSK
Sequence: MSLIREIAGGPYALAAGPDGAMWVTLVHDGAIARVGADGAVDRFPVADGSRPSLISAGPDGALWFTRNGDDRIGRLTTAGELTEFPLSEGSAPFGICAGADGALWFTEMGSGGIGRITVDGQTSGWASVGGTPSMITRGPDDAVWFTLNQGNAIGRLHPRDGVTMRELPTRGAGPVGITATHDDAIWFTEILADKLGRIPLDGALQEIDLPGKPHAVVADPSGGVWVSLWGADRLARVSADGDIETFDLPPGSEPHGLAFGPDGGLWVALESGFVLRMPD
What is the function of this protein?
Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.
What are the official names of this protein?
Virginiamycin B lyase, Streptogramin B lyase.
What is the protein family that this protein belongs to?
Belongs to the Vgb family.
Protein: DTDA_HALS3
Sequence: MIGIVVSRADGASTHIWAQLREIEDFERIGPDAYRADGIEVRVFEELHTTIDDAADAFEAAVDMVVVVSRHSGDTGPLLSAHYTGNFGAAEYGGADRSVAPACPNAHHAVVDSLRSYAPPEYDVAMECTHHGPTSVGAPSMFVELGSSPAEWQDDAGARAVARAVRDLRGVPPHGDRAVVVFGGGHYTPRATRILADTDWPVGHVAADWSLTELGRPNAHRGVVDAMFTASGAAHALVEGDRPELTETIRDLGYTVVSETWVRETDGVPLSRVAALEESLTTVDDGLRFGEPAATHTGGYLVVELPDAVLDAAHAVDTAATVAAGRSHALAVTTVNAGRRLAGSAAFPDADAYEAFVDDVAAVLNAEYASVSRADGELTATREVFDPEAAAALGVPEGPAFGRLAGGEAIEHDGRTIAPAAVTSTETVRADVALHERPRERVRRPSDDEGKGN
What is the function of this protein?
D-aminoacyl-tRNA deacylase with broad substrate specificity.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, D-tyrosyl-tRNA(Tyr) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DtdA deacylase family.
Protein: GLGC_GEMAT
Sequence: MTPSNRGTLARTAMAYVLAGGRGSRLYELTDPRAKPAVYFGGKTRIIDFALSNAINSGIRRIGVATQYKAHSLIRHLQRGWNFMRPERNESFDILPASQRVSETQWYDGTADAVYQNGDIIADYAPEYMVILAGDHVYKMDYELMLQQHVNQNADVTVGVLEVPQREASGFGVMHVDANDRIITFLEKPDDPPGIPGAPHLSLASMGIYVFRTTYLFELLRADAADPHSSHDFGKDIIPTVVRHGKAIAHRFSTSCVRSQDESLAYWRDVGTIDAYWEANIDLTTVTPQLDLFDKDWPIWTYSELTAPAKFVHNEEGRRGHALNSLVSGGCIVSGSYLHKSLLFTGVRVHSYSHLEGAVVQPYVDIGRAARLRNVVVDRGVRIPAGLVVGEDPVLDARRFRRSARGTVLITQPMIDRL
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: PCSK9_PONPY
Sequence: MGTVSSRRSWWPLPLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGATATFHRCAKDPWRLPGTYVVVLKEETHRSQSERTARRLQAQAARRGYLTKILHVFHDLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLMPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSVEPELTLAELRQRLIHFSAKDVINEVWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVCAIARCCLLPQANCSVHTAPPAGSGMGTRVLCHQQVHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCRAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDISTTGSTSEEAMAAVAICCRRRHLAQASQELQ
What is the function of this protein?
Crucial player in the regulation of plasma cholesterol homeostasis.  Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.  Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway.  May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.  Can induce ubiquitination of LDLR leading to its subsequent degradation.  Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner.  Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.  Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation.  Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 9, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity).
Protein: SYV_SCHPO
Sequence: MADKGCEAAQSKDSSAPGSGEPRPKTEKELERERQKAAKLEKYHAKLAAKKAKEEARKPKLDKKAKIASPVAEYVEKTTPGEKKVLQDLDSPALKSYNPKAVESAWYDWWVKSGFFEPEFGPDGKPKKEGVFVITSPPPNVTGALHIGHALTIAIQDSLARWNRMLGKTVLFLGGFDHAGLSTQSVVEKKLWYTQKKTRHDYPRDKFVDIVWEWKEEYHNRIKNQMSRLGGSFDWTREAFTMDENLSRAVVETFVRLHEENIIYRANRLVNWCTALQTTLSNLEVENVDVPGRTLLKVPGYDEPVEVGVLTSIAYAVEGSDERIVIATTRPETLLGDTAVAVHPQDPRYKHLHGKFVKHPFCNRSIPIICDDIIVDMEFGTGAVKITPAHDPNDYEVGKRHNLEFINIFTDDGLLNENCGEFAGMKRFTARVKVVERLKELGLFVGTKENPMVIPLCGKTSDIIEPVMKPQWWVNQKEMAAAAAEVVKSGEIEIAPDMSRREFIRWMENIQDWCISRQLWWGHRIPAYFVNLADEPSQDRSEGRYWVTGRTLEQAEEKAKAAFPGKSFTLEQDEDVLDTWFSSGLWPFSTLGWPKDTSDYENFYPTTLMETGWDILFFWIARMVMLGLKLTGKIPFKRVFCHALVRDAQGRKMSKSLGNVVDPIDVIEGISLQALHDKLLVGNLDSREVEKAKKGQRLSYPKGIPQCGTDALRFTLCSLTTGGRDLNLDILRVEGYRKFCNKLYNATKFALGRLGSNFVPNKTADLTGNESLVEKWIFHRLNIAAAAMNKNMEEMNFLQATSAVHQFWLYELCDVYIENSKYLLSDGTEVQQESAKQTLYTVLDNALRLMHPFMPYVTEEMWQRLPRRPGDKTQTIVKAAFPVERVDYSNEIAAKYYESIITVVHSTRSMMAENGIKSDAVVYIHPDEEHSKLITSESASIQSLIKKCKTLSIVDNTFDSDKCVKNEVLEGSTIFLERNN
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THS2_ARAHY
Sequence: LKENPNMCAYKAPSLDAREDMMIREVPRVGKEAATKAIKEWGQPMSKITHLIFCTTSGVALPGVDYELIVLLGLDPSVKRYMMYHQGCFAGGTVLRLAKDLAENNKDARVLIVCSENTAVTFRGPSETDMDSLVGQALFADGAAAIIIGSDPVPEVENPLFEIVSTDQKLVPNSHGAIGGLLREVGLTFYLNKSVPDIISQNINDALSKAFDPLGISDYNSIFWIAHPGGPAILDQVEQKVNLKPEKMNATRDVLSNYGNMSSACVFFIMDLMRKKSLEEGLKTTGEGLDWGVLFGFGPGLTIETVVLRSVAI
What are the official names of this protein?
Putative stilbene synthase 2, Resveratrol synthase 2, RS2, Trihydroxystilbene synthase 2.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_HELMI
Sequence: MIKKLDRDAARQKKHMRIRKRVKGTEERPRLCVFRSLNHIYAQVVNDVTGRTLVAASSLDGEFKAANVSGGNIEGAKKVGELIAKKALEKGIDKVVFDRGGYIYHGRIAALAEAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ATPL_BACCA
Sequence: MSLGVLAAAIAVGLGALGAGIGNGLIVSRTIEGIAAQPELRPVLQTTMFIGVALVEALPIIGVVFSFIYLGR
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TBB_THAWE
Sequence: MREIVHIQGGQCGNQIGAKFWEVMSDEHGVDPTGTYHGDSDLQLERINVYFNEATGGRYVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCMQGFQLTHSMGGGTGAGMGTLLISKIREEYPDRVMSTYSVIPSPKVSDTVVEPYNATLSVHQLVENADQCFALDNEALYDICFRTLKLTTPTYGDLNHLIAAAVCGTTCCLRFPGQLNCDLRKLAVNMVPFPRLHFFMVGYAPLTSRGSQQYRALTVPELTQQCFDAKNMMCAADPRHGRYLTCAVLFRGRMSSKEVDEQMLNVVNKSSSYFVEWIPNNVKASICDIPPKGLKMATTFVGNTTAVQETWKRVAEQFTVMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEGEFDEDEMEG
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TATA_JANMA
Sequence: MGSFSIWHWLIVLVIVMLVFGTKKLGNMGSDVGKAVKGFKDGMKGGEDDKPAAQNAAPSQVADKGTVDVEVKEKSNS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IPO9_HUMAN
Sequence: MAAAAAAGAASGLPGPVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHLAELTVDPQGALAIRQLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRESISKVRSSVAYAVSAIAHWDWPEAWPQLFNLLMEMLVSGDLNAVHGAMRVLTEFTREVTDTQMPLVAPVILPEMYKIFTMAEVYGIRTRSRAVEIFTTCAHMICNMEELEKGAAKVLIFPVVQQFTEAFVQALQIPDGPTSDSGFKMEVLKAVTALVKNFPKHMVSSMQQILPIVWNTLTESAAFYVRTEVNYTEEVEDPVDSDGEVLGFENLVFSIFEFVHALLENSKFKSTVKKALPELIYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTVRIAAQDLLLAVATDFQNESAAALAAAATRHLQEAEQTKNSGTEHWWKIHEACMLALGSVKAIITDSVKNGRIHFDMHGFLTNVILADLNLSVSPFLLGRALWAASRFTVAMSPELIQQFLQATVSGLHETQPPSVRISAVRAIWGYCDQLKVSESTHVLQPFLPSILDGLIHLAAQFSSEVLNLVMETLCIVCTVDPEFTASMESKICPFTIAIFLKYSNDPVVASLAQDIFKELSQIEACQGPMQMRLIPTLVSIMQAPADKIPAGLCATAIDILTTVVRNTKPPLSQLLICQAFPAVAQCTLHTDDNATMQNGGECLRAYVSVTLEQVAQWHDEQGHNGLWYVMQVVSQLLDPRTSEFTAAFVGRLVSTLISKAGRELGENLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFVMAEWTSRQHLFYGQYEGKVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSKSAKNPERWTNIPLLVKILKLIINELSNVMEANAARQATPAEWSQDDSNDMWEDQEEEEEEEEDGLAGQLLSDILATSKYEEDYYEDDEEDDPDALKDPLYQIDLQAYLTDFLCQFAQQPCYIMFSGHLNDNERRVLQTIGI
What is the function of this protein?
Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:34711951, PubMed:30855230).  Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430).  Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430).  At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430).  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430).  Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951).  Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230).  In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230).  Mediates the nuclear import of actin (By similarity).
What are the official names of this protein?
Importin-9, Imp9, Ran-binding protein 9, RanBP9.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.