PharMolix/UniProtQA huggingface dataset:
Protein: HUS1_MOUSE
Sequence: MKFRAKIVDLACLNHFTRVSNMIAKLAKTCTLRISPEKLNFILCDKLASGGVSMWCELEQENFFSEFQMEGVSEENNEIYLELTSENLSRALKTAQNSRALKIKLTNKHFPCLTVSVELVSSSSSSRIVVHDIPIKVLPRRLWKDLQEPSIPDCDVSICLPALKMMKSVVEKMRNISNQLVIEANLKGELNLKIETELVCVTTHFKDLENPLLPSDSVSQNRHPEDMAKVHIDIKKLLQFLAGQQVTPTKAVCNIVNNRTVHFDLLLEDVSLQYFIPALS
What is the function of this protein?
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.  The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.  Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER).  The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.  The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (By similarity).
What are the official names of this protein?
Checkpoint protein HUS1, mHUS1.
What is the protein family that this protein belongs to?
Belongs to the HUS1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In discrete nuclear foci upon DNA damage. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.
Protein: TLP2_PRUPE
Sequence: MMKTLGAVLSLSLTLLSFGGAHAATMSFKNNCPYTVWPASFGNPQLSTTGFELASQASFQLDTPVPWSGRFWARTRCSTDASGKFVCETADCDSGQLMCNGKTGIPPATLAEFTIAAGGGQDFYDVSLVDGFNLPMSVTPQGGTGTCKMGSCAANVNLVCPSELQKIGSDGSVVACLSACVKFGEPQYCCTPPQETKEKCPPTNYSQIFHEQCPDAYSYAFDDNKGLFTCSGGPNYLITFCP
What is the function of this protein?
May be involved in protecting plant tissues from pathogen infection.
What are the official names of this protein?
Thaumatin-like protein 2, PpAZ8.
What is the protein family that this protein belongs to?
Belongs to the thaumatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: BRD9_XENLA
Sequence: MNVSVTKRRKKKKKKKSEKEKDKYLDEDERRRRKEEKKRKREKEQCDSEGETEVFESIRKDIEATDRPVRTCRTHPENESTPLQQLLEYFLRQLQRKDPNGFFAFPVTDQIAPGYFMIIKNPMDFSTMKEKISQDEYKSVTEFKADFKLMCDNAMTYNRPETVYYKLAKKLLHTGFKMMSKAALLGNEVTTTEEPIPEIIMPTAAEVVKKSKKPSKDMFRVMEEDQSSIFEPEGNACSLTDSTAEEHVLALVEHAADEARDKLNQYFPNCRIGYLKKNTDGTLFYTVVNGDPDNEEDTHLVDLSSLSSKLLPSFTTLGFKEDRRHKVTFLNSTGTALSLQNNTLFTNLKPDQIELMYAGYGDDTGIQCALSLQEFVKDSGSFAKRMVNDLLDQITGGDHSRTIYQIKQMTGSEREGCSNSVLDFMTLKSYSDVSLDMSMLSSLDKVKKELEHEDSHLNLDDASKLLPDFHDVHNDRGGSRPSSSSSMSNNSERDHHLGSPSRISVGEQQDIHDPYEFLQSPETDNQN
What is the function of this protein?
Plays a role in chromatin remodeling and regulation of transcription.  Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated.
What are the official names of this protein?
Bromodomain-containing protein 9.
Protein: AAS_ECOLC
Sequence: MLFSFFRNLCRVLYRVRVTGDTQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLDPTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQITLHILPPTQVAMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTKTLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKVHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEAEQHDE
What is the function of this protein?
Plays a role in lysophospholipid acylation.  Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium.  Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
What are the official names of this protein?
Bifunctional protein Aas.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL36_MYCSK
Sequence: MKVNPSVKPICDKCRVIRRHGRVMVICSDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LACB3_FELCA
Sequence: ATVPLTMDGLDLQKVAGTWHSMAMAASDISLLDSEYAPLRVYVQELRPTPRDNLEIILRKWEQKRCVQKKILAQKTELPAEFKISYLDENELIVLDTDYENYLFFCLENADAPGQNLVCQCLTRTLKADNEVMEKFDRALQTLPVDVRLFFDPTQVAEQCRI
What is the function of this protein?
Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
What are the official names of this protein?
Beta-lactoglobulin-3, Beta-LG-3, Beta-lactoglobulin III.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PURR_ECO57
Sequence: MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: RL22_METAR
Sequence: MSKVGYTAEFDPATTAKAMAYEINVSPKHCQEICRQIRGMKLSAAKTYLQDVIDKKRSVPFKQHARNVGHKRHQSGWPSGRYPVKASTEILKLLKHAEANAEYKGLETENMRIIHSTSKKGRVIQGIMPRAMGRATAWNIELVTVEVVIGEVR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: POA1_CANGA
Sequence: MSNIHYIKGNILKGRTYKRIIIHSCNANGAWGGGIAYQLAVKHPKAEEVYVDLCERFGQKLLGKCVVIPSYSDDDVLIGCLFTSIFGGASHGSGTSIVDYTDKALSHFDELLAKEQSKSDNANLDKEIEKLLKLKSGVLKDYKLEMPKINSGIFGVPWPETEEVLKKYDRSMNFTVYEL
What is the function of this protein?
Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.
What are the official names of this protein?
ADP-ribose 1''-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the POA1 family.
Protein: RL13_METC4
Sequence: MKTTSLKPADVDKKWVVIDAEGLVVGRLASIVAMRLRGKHKPAYTPHVDCGDHVIVINADKVKFTGRKYDQKVYYHHTGYPGGIKERSAKFILEGRFPERVVEKAVERMLPRGPLFRQILGHLRVYKGAAHPHEAQQPQALDVGSLNRKNVSA
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: FBX15_HUMAN
Sequence: MATGRGRILQQHWLGLQTLRGPSRGGGAARGRARAFGCRKGPGVKLSAGSAALRCHAGGGQHWESSFSCCSGFLDGMPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEKIAMSMSFLSVQDKEAGYWKKEYITKQIASVKAALADILKPVNPYTGLPVKTKEALRIFGLGWAIILKEKGGKEYIMEHVDLSINDTSVTVIWYGKKWPCLASLSTLDLCGMTPVFTDWYKTPTKHRLRWHSLIAKYNLSHLTISTMIGCDRLIRIFCLHPGLLVGVWKKEEELAFVMANLHFHHLVERSTLGSATIPYELPPHSPFLDDSPEYGLHGYQLHVDLHSGGVFYLCGTFRNLFTKRGNIENGHVKLIVIHLKNNREHLPLIGKVGLSWKTDIFDGCIKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVNLVLYLSIAKINHWFGTEY
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
What are the official names of this protein?
F-box only protein 15.
Protein: DNLJ_SALAI
Sequence: MPEDAIGQQVPPEQEAAGAEPTSAARERHATLSLELTEHQYRYYVLDAPTISDAEFDERLRELAALEAEFPALRTPDSPTQRVGGAFSTDFTPVAHAERMMSLDNAFTDEELDAWAERVERDAGGPVPYLCELKVDGLAINLTYERGRLVRAATRGDGRTGEDVTANVRSIRDVPAELAPSAEFPEIPGLLEVRGEIYFPIAGFADLNAGLVEQGKAPFANPRNAAAGSLRQKDPRITASRPLRLVVHGIGARQGWQPSTQSESYAALRAWGLPTSDRWRVVPDLAGVAEYIAHYATHRHDVEHEIDGVVVKVDPVSIQGRLGSTSRAPRWAIAFKYPPEEVNTRLLDIDVNVGRTGRVTPFAVLEPVRVAGSTVALATLHNAREVRRKGVLIGDTVVIRKAGDVIPEVLGPVVELRPPDARSFVMPSTCPCCGTPLAPAKEGDVDIRCPNTRSCPAQLRERVFHLAGRGAFDIEVLGYKGAAALLDAQIITDEGDLFALDAAQLTRSPFFVNKDGSLGSNAVKLLDNLTVAKERELWRVLVALSIRHVGPTAAQALARHFRSIEAIDQAGEEELSAVDGVGPTIAASVREWFAVAWHREVVRKWAEAGVRMTEEAVDEGPRPLEGMTVVVTGTLAGFSRDQAAEAIQSRGGKVTGSVSKKTAFVVVGENPGTKADKAASLKVPVLDEEGFRVLLDAGPDAAREVARVED
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PETD_ZYGCR
Sequence: MGVTKKPDLTDPVLRAKLAKGMGHNYYGEPAWPNDLLYIFPVVIFGTIACNVGLAVMEPSMIGEPANPFATPLEILPEWYFFPVFQILRTVPNKLLGVLLMAAVPAGLLTVPFLENVNKFQNPFRRPVATTVFLIGTVVSIWLGIGAAMPIDQSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y1370_METJA
Sequence: MITVGIDHGTSGITTCIKDNDKKIIFKLKRTELKEKSYLEELEKHISLEDIDLIALTYSMGDGINKILPIEKVKNRGVLSIEGAGEKVGGGTKVYDEIKESGLPAVVIPGLHRGIECLDERFRALYSHIASPEKVSIAYYAYKLFGFNDFVLSDISSNTVTLLIKDGKIFGGFDACIGAIGMLHGPIDLEMIRDIDAGKITANEAFSKAGAVKIAKLYKGVENTKEEIINNYFNDENCRLAVDSLILSVSMEINSLLPLLDKNKRRVVLAGSIGTLRNPIDIPKRIKEFVEAKIFVLYGESGAIGGALIAEDILKGKRDILGIEVEFK
What are the official names of this protein?
UPF0285 protein MJ1370.
What is the protein family that this protein belongs to?
Belongs to the UPF0285 family.
Protein: PFD6_YEAST
Sequence: MSELGAKYQQLQNELEEFIVARQKLETQLQENKIVNEEFDQLEEDTPVYKLTGNVLLPVEQSEARTNVDKRLEFIETEITRCEKNIRDKQEELEKMRSELIKLNNTAASTGPGR
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
What are the official names of this protein?
Prefoldin subunit 6, Genes involved in microtubule biogenesis protein 1, Gim complex subunit 1, GimC subunit 1.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BGAL_ASPNG
Sequence: MKLSSACAIALLAAQAAGASIKHRINGFTLTEHSDPAKRELLQKYVTWDDKSLFINGERIMIFSGEFHPFRLPVKELQLDIFQKVKALGFNCVSFYVDWALVEGKPGEYRADGIFDLEPFFDAASEAGIYLLARPGPYINAESSGGGFPGWLQRVNGTLRSSDKAYLDATDNYVSHVAATIAKYQITNGGPIILYQPENEYTSGCSGVEFPDPVYMQYVEDQARNAGVVIPLINNDASASGNNAPGTGKGAVDIYGHDSYPLGFDCANPTVWPSGDLPTNFRTLHLEQSPTTPYAIVEFQGGSYDPWGGPGFAACSELLNNEFERVFYKNDFSFQIAIMNLYMIFGGTNWGNLGYPNGYTSYDYGSAVTESRNITREKYSELKLLGNFAKVSPGYLTASPGNLTTSGYADTTDLTVTPLLGNSTGSFFVVRHSDYSSEESTSYKLRLPTSAGSVTIPQLGGTLTLNGRDSKIHVTDHNVSGTNIIYSTAEVFTWKKFADGKVLVLYGGAGEHHELAISTKSNVTVIEGSESGISSKQTSSSVVVGWDVSTTRRIIQVGDLKILLLDRNSAYNYWVPQLATDGTSPGFSTPEKVASSIIVKAGYLVRTAYLKGSGLYLTADFNATTSVEVIGVPSTAKNLFINGDKTSHTVDKNGIWSATVDYNAPDISLPSLKDLDWKYVDTLPEIQSSYDDSLWPAADLKQTKNTLRSLTTPTSLYSSDYGFHTGYLLYRGHFTATGNESTFAIDTQGGSAFGSSVWLNGTYLGSWTGLYANSDYNATYNLPQLQAGKTYVITVVIDNMGLEENWTVGEDLMKSPRGISTSCLPDGQAAPISWKLTGNLGGEDYEDKVRGPLNEGGLYAERQGFHQPEPPSQNWKSSSPLEGLSEAGIGFYSASFDLDLPKDGMSHCSSTSVTALRHPRTACRSTSTDIVCEIHKQHRTSDQLPCPRGNPELSRNELVGGDPVALDSAGGKLESLELSYTTPVLTALGEVESVDQPKYKKRKGAY
What is the function of this protein?
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
What are the official names of this protein?
Beta-galactosidase, Lactase-N, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
Protein: PT2K2_SOLTU
Sequence: MATTKSFLILFFMILATTSSTCATLGEMVTVLSIDGGGIKGIIPAVILEFLEGQLQEVDNNKDARLADYFDVIGGTSTGGLLTAMITTPNENNRPFAAAKDIIPFYFEHGPHIFNYSGSIFGPMYDGKYLLQVLQEKLGETRVHQALTEVAISSFDIKTNKPVIFTKSNLAKSPELDAKMYDICYSTAAAPMYFPPHYFITHTSDGDIYEFNLVDGAVATVGDPALLSLSVATRLAQEDPAFSSIKSLDYKQMLLLSLGTGTNSEFDKTYTAEEAAKWGPLRWLLAIQQMTNAASSYMTDYYISTVFQAHHSQNNYLRVQENALTGTTTEMDDASEANMELLVQVGETLLKKPVSKDSPETYEEALKRFAKLLSDRKKLRANKASY
What is the function of this protein?
Probable lipolytic acyl hydrolase (LAH), an activity which is thought to be involved in the response of tubers to pathogens.
What are the official names of this protein?
Patatin-2-Kuras 2.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
What are the subcellular locations of this protein?
Vacuole.
Protein: ISPE_TREPA
Sequence: MQSLSLRAHAKVNMHLWVGARRADGLHSIESVMQRITLADSLSLSRLDIPGRCEVCSPYMALPRENTLTRAYARFCQVTGVHDGVRVRVVKRIPAGSGLGGGSADAAALLCGLDTLFGTTLSARVLREVAYSVGSDVPFFLASQAACVLGGGEQLVPLVPKTGYLGLLVWPGLHSGSAQAYEDLDRLRACGVHAADGEQYSLRGATALSAHYAQDCARWRFFNSLDAPVQRRYPVVALARWDLARAGACFTAMSGSGSXVFGLYRDEEELRRAHKLLAKRWCWCVRVRLCG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PSB_NOCSJ
Sequence: MSDPRLPAAFLQPGSSSFSDFLAVQAPDLLPGRRAVPQGHAGDLAPHGTTIVAATFPGGVVMAGDRRATMGNIIAQRDIEKVFPADEFSAVGIAGSAGLAVEMVRLFQTELEHYEKIEGSTLSMDGKANRLAALIRSNLGMAMQGLAVVPLFAGFDLASNQGRIFSYDVTGGRYEETAFHSVGSGSLFARGSLKKLYRDDLTAEQTVQAVVEALYDAADDDSATGGPDVTRRIFPVVQVMTADGGRRMPDADVATIADRVIAGRMTSPDGPTAPLTARPLEGA
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PrcB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDE6D_DROER
Sequence: MGSDDQSAGDRIQKGFQINYMILRDADSGKIIWQENKDFSAPDQEHEARVPVKILEMRAVSREINFSTIESMENFRLDQKVLFKGRIMEEWFFEMGFVGANTTNTWQSTIEAAPESQMMPAKVLNGNVTIQTSFYDNETLITKSVVRLYYI
What are the official names of this protein?
Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the PDE6D/unc-119 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RPOB_LEPIN
Sequence: MYGQVERKRVNFGKITNLDYLPNLIQIQKRSFDWFLQADVKDETKRRHQGLEAVFRETFPIESPNNDMIMEYSHYILGEPKRSPQECKDTDATFAMPLKAVIRLIIKETGEIREQTVYMGDLPVMTEQGTFIINGAERVVVSQLHRSPGIFFSYDMERDVFSARVIPYRGSWLEFEMDNKGILIAKIDRKKKFPATLLVKSLGHGTNEEVLRLFYSSKKEKIAGATSKDLKKILGRRTINDIINMETGEVMLEAGSKINEDNISILKEMKVKEVELIEFPKGKDNPILINALEKDGVNDYEDAILKFHSLMRQGEPSTIENATTELTRLFFSPKTFDLGEVGRYKINSKFEFNNPKEFSGEKARVLRPADIIETVRYILNLFSETENYYPDDIDHLGNRRIRSVGELISNQLKTGFSRVERVIKERMTVQEIETQTPQLLISIKPITAVINEFFGSSQLSQFMDQTNPLAELTHKRRLNALGPGGLSRDRAGMEVRDVHYSHYGRMCPIETPEGPNIGLILSMSSYARVNDYGFLETPYRTVKNGKVTGQIEHLTADKEEYHYIAQASGVIDEKGELKNKLISTRHRGDFPFRNPSEIQYMDLAPLQVVSVSTALIPFLEHDDANRALMGSNMQRQAVPLLREEAPFVGTGMETRAAYDSRICIVNKHDGVVTSVDAENIVVERKGGKESDTYQLTKFKKTNQGTCFNQKPIVGVVHSEINGKVSKVSKEKIEVTGENGELKEYVLQIGSKQYSPIVSAGEEVKRGSTLAGQVVVGEKLDEMGNILVKGTVLADGPAVDNGVLALGRNVLAAFMPWEGYNFEDAILISERIVRDDVFSSIHIEEFEIQARETKLGPEQITRDIPNLSDKAFRDLDETGVIRIGAEVKPGDILVGMVTPKGETDLTPEYKLLHSIFGEKAKDVRDSSLRMPNGFEGTVIDIKRFSRENQDELPAGVEEMVKVFVARKRKLLVGDKMAGRHGNKGVVARVMAEEDMPYMEDGTPLDIVLNPLGVPSRMNLGQIFETQLGFAASKLGISFETPVFDGAEESDVDNFCKEANLPLNSKFKLYDGRTGLPFMNEVFCGYIYILKLAHLVEDKIHARSTGPYSLVTQQPLGGKAQFGGQRLGEMEVWALEAYGASHTLQELLTIKSDDMLGRARIYEAIVKGIHSIKPGIPESFNVLVQELRGLALDIIITDSEGNTVDISDYEDEYSKSKKKIKFETIENA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: AL5AP_RAT
Sequence: MDQEAVGNVVLLAIVTLISVVQNAFFAHKVELESKAQSGRSFQRTGTLAFERVYTANQNCVDAYPTFLVVLWTAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSLAGILNHYLIFFFGSDFENYIRTITTTISPLLLIP
What is the function of this protein?
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase).  Anchors ALOX5 to the membrane.  Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5.  Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).
What are the official names of this protein?
Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MDAR3_ORYSJ
Sequence: MASEKHFKYVILGGGVAAGYAAREFAKQGVKPGELAIISKEAVAPYERPALSKGYLFPQNAARLPGFHVCVGSGGERLLPEWYSEKGIELILSTEIVKADLASKTLTSAVGATFTYEILIIATGSSVIKLSDFGTQGADSNNILYLREVDDADKLVAAIQAKKGGKAVIVGGGYIGLELSAALKINDFDVTMVFPEPWCMPRLFTADIAAFYESYYTNKGVKIVKGTVAVGFDADANGDVTAVNLKNGSVLEADIVVVGVGGRPLTTLFKGQVAEEKGGIKTDAFFETSVPGVYAVGDVATFPMKMYNELRRVEHVDHARKSAEQAVKAIKGKESGESVVEYDYLPYFYSRSFDLGWQFYGDNVGDTILFGDSDPTSAKPKFGSYWIKDGKVLGAFLEGGSPDENKAIAKVAKTQPPVANIEELKKEGLQFASKI
What is the function of this protein?
Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process.  Ascorbate is a major antioxidant against reactive oxygen species (ROS) and nitric oxide (NO) (PubMed:24376554, PubMed:27652777).  Can use NADPH as electron donor, but possesses lower activity compared to NADH as electron donor (PubMed:27652777).
What are the official names of this protein?
Monodehydroascorbate reductase 3, cytosolic, OsMDAR3, OsMDHAR3.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BEX4_RAT
Sequence: MASKVKQVILDLTVEKDKKNKKGGKASKQSEEESHHLEEVENKKPGGNVRRKVRRLVPNFLWAIPNRHVDHSEGGEEVGRFVGQVMEAKRKSKEQQMRPYTRFRTPEPDNHYDFCLIP
What is the function of this protein?
May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability.
What are the official names of this protein?
Protein BEX4, Brain-expressed X-linked protein 4.
What is the protein family that this protein belongs to?
Belongs to the BEX family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle pole. Nucleus. Cytoplasm. Note=Also localizes to microtubules.
Protein: RAH1E_ARATH
Sequence: MASVSPLAKYKLVFLGDQSVGKTSIITRFMYDKFDTTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVIVYDVANRQSFLNTSKWIEDVRTERGSDVIIVLVGNKTDLVDKRQVSIEEGDNKARDYGVIFIETSAKAGFNIKPLFRKIAAALPGMETLSSTKQEDMVDVNLKTSSNSAQGEQQRGGCAC
What is the function of this protein?
Protein transport.  Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) (By similarity).
What are the official names of this protein?
Ras-related protein RABH1e, AtRABH1e.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid- anchor.
Protein: MLRV_RAT
Sequence: MSPKKAKKRLEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
What is the function of this protein?
Contractile protein that plays a role in heart development and function (By similarity).  Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force.  These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (PubMed:15331360).  During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
What are the official names of this protein?
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC-2, MLC-2v, Myosin light chain 2, slow skeletal/ventricular muscle isoform, MLC-2s/v.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, A band.
Protein: UBIG_YERPY
Sequence: MRAKTTSRHHNVDEQEIAKFEAVASRWWDLEGEFKPLHRINPLRLNYILQRSGGIFEKKVLDVGCGGGILAESMAREGAQVTGLDMGYEPLQVARLHALETGVKLEYVQETVENHAQQHPQHYDVVTCMEMLEHVPDPASVVRACAQLVKPGGHVFFSTINRNTKSWLMAVVGAEYLLKMVPKGTHDAKKFIRPSELIGWVDQTPLLERHIIGLHYNPITDHFKLGRNVDVNYMVHTQRDSE
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.