Protein: SAN1_FUSV7
Sequence: MVPEKPTAQSKSGIGEPFRAGDAAGLHIPTSEINSTYLDDTFPSLFSTMHQFRENDAVKAYPSGGIEKFGDIRATVQPVSSGSSDTSSSDDSQQLQHAVEYWKDILADGKFVSYPSPPASTQQRSSLSGLAPHAVEQLQLPLPKHSKVPPATLMRAAWALVAGRMTDSESIVFGTNVLDEPILSAVPFRAHIHGHTVSSFIESVQKQEEEVMASPHQLTLLFSGMEQASTLFQTLLLIPSDEEYSNSPQDSGCRTPEPCGFGLVLEIAHTQDRASLKVTARYRSDTLQAFEVKRLLHRFASVMAQLDTVKPDQSVDEIDFMTEQDFQDIWAWNSKAPAAINGFIHDIVKEKALIQPSSTAVYAWDGEFTYAEIDRHSNRLAVTLITGYGVQPGTPIALCFEKSKWMAVSMLGVLKAGAYFVMLDAASAPEQRLRTMVEQVQARLVISSPLNQALSSRICAAVVTLDSQTLRECKYNDDEIDRLLHQQLLTSSSNALAHVIFTSGSTGTPKAIPTTHQSIRSALHHQVAAIHLNTKSRVYDFSSYSFDAAIFNIWATFYAGGCLCVPSEADRKDDLVGSFQRLGANHVIMTPSAAQLLASAPEKVPQLETIMLVGERLTIQDVLPWWNRVCLINSYGPCECTPLGTSNLNPSSPTDLLDIGVGLGQVTWIVDPDDHNRLVPPGLIGELVLEGPSVSQGYLNDPERTAAAFVKDPAWLVERGRHGKVYKTGDLVQYSNEQGRLKYIGRKDAQVKIRGQRVELGEVEHRVQQCMPDVSQVVVEMITPKSGNNLSSAMLAAFLVPSRGSGKEVSEPRMAQSIPQIYAVSEEVQSALSKALPSYMVPSVFFSVRDLPKAASSGKLDRKKIREMGSSFSVKQLADLRTNAQGPKRQPRPFSVEYSLQGIWASVLNMERSDIGLNDSFFQLGGDSISAMKVVRDAREQLEVELSVADILQHPRLSEAAAIVARGTKLFKSDEVPAAFSLLPGNNAREAIDPALKSHGVQSLSVEDAFPCTPLQEGLVFLSLKSPGDYIMQTTLDLSTSSYSNAHKFRQAWEHVVAEHPALRTRFVHSDGETGLAQVVLRPEAFAWNEVANSSLNEYLETDRRQPMSLGQAFARCALVHDKGAPRWFVWTMHHALYDGWSIRLIMNAFQRAYRSLEAGSNLVTGTTNASYPAFIKYILSQSVSADGSMAKYWKKTLSDCEAAQFPAVPLHVQNQAPDHDKINTLFQDLPSMTKKQGISNATPSTLIRAAWALVVRSMTNSDDVVFGVTVSGRSAPVAAIDEVPGPTMATVPFRSILAKNMLVGDYLRSVQQQAIDMIPFEQIGLPRIAKLSADCEHACRFQTLLVVQPEETADILSEFDDEHGGPERWFNNTYALLLEVQLGDKKANSSGAVKARFDSRIIQANTVKSLLERLIFVIDQLSGADNMARVLSDIDVVTPVDLEQIWQWNKTVPATIDRNVHDMILERALSQPDRPVVLAWDGELTYGELTRLSSTLARRLIDQYGVRPGDIVGLCFEKSKWTSVAILAVLQAGAGFAMLDPFLPETRLQTIVDQVNALVVVSSPKQRDLSLQLGCDQVLHLASDLFSEPETALVNVKTDPSSPVYIIFTSGSTGTPKGSIISHRSLASSLVHQREGCGFSQSSRVYDFSSYGFDAPLFLAFQTFSAGGCLCVPSDEDRKSRLAESLRELKATFALIPPSASQLVSPEQVPDLKTLIVGGEASTVKDLERWSSADLMLINAYGPCECTAVSMINPTHTSNMSVRKALAIGKGLGQVTWVVDPQDHSRLVSPGAVGELLLEGPYIGQGYLNNEEKTREAYVKDPAWLLQGTGKVPGRRGRLYKTGDLVQYSEDGDGSLMFVGRKADDAQVKIRGQRAELGEIELRVQQALKYDKTVQEVVVDVIVPHGEGSRPMLVAFLKTTDVKDTSATPDLYRVSSAFEDELAQSLPSYMIPEAFFKLAGIPQTATGKLHRMRLRAMGASYSLRQLADLRTEATQGPKPQPTSELEAEMQQIWARVLSFEPERIGLDDSFFRLGGDSIAAMKAVGEATKASIRVTVADFFEHRTLRNICSHSYYCSEMAAESLSIAVESFSLLAPDSIETREKLVQGLAAQLRTTTSRIQDAYPCTPLQEGLVSLASKRTGDYIMQQVLELSPDMLNNIDTFKDAWQKAVHAVPVLRTRIVQHEKLGLLQVLLNHQDEGIEWTEAMGLDWYLKSDRQKPMGLGQPLARYALVRDRTGRPKWFVWTVHHALYDGLSLPMILEEVDRTMQGQSVEQARPQAQAFIKYIQQHDSNELKSYWQATLGDSGECVSYPSLPSGLERPIMSNNLIEHQIPRAWVSSSSNETTVSTMLRAAWGLVTSQMTGSDDVVFGATVSGRNAPVVGVESMAFPTIATVPLRLKLNRKDQRVVDYLDQVQRQATEMIPYEQAGLQRIAQLVSPGARQACAFQTLLVVQPKSKTESTKTSQLGEWTTPDQTEWFTTYPLTIEATVSLSQIDVDARFDSRVVEPWMVKGLLERLDFVMQQLGQAGPDINMSDIGIMTPGGLQQIWKWNEKVPDPVDRSIHSVIEEQARLRPEAAAICAWDGNLTYAELNSFSSRLAFYLIALTGGKSLKETFVPLCFDKSMWTPVAMLGVLKTGAGFVLLDSALPEQRLRHIVEKVGAGQLMLSSDSCSSLSGRISQGVVTINSDFFKLAAQTIARLPVASADSAAYVIFTSGSTGTPKGVVITHRNLASALPYHVKRLGYTPDSRVYEFASYSFGASLNNMFTALTTGSCLCIPSDHERRSQLDRSLVSMNATHVLLTPSVAESLAPRSVSGLKSIIFGGEAVRSQDVGPWWEAGIKVCTAYGSSECTTISTINDTASTPDEATRIGWGVGLVPWVVDPSDHEKLLPPGCIGELLLEGPAVGRGYLSDPEKTAEVFIQSPSWLTRGIPAANNDNHSQKGRSGRLYKTGDLVRYNEDGSLSFFGRKDSQVKIRGQRVELGEVEHRVKERVSEAAQVVVEAIIPTGSDSAHQTLAAFLVMKEETERPASDDDKPTIIPISAGVEDMLSQNLPVYMVPTVFFSMKKLPMTATGKMNRRVLRQIGSSFSAKQFAAARKTREQGTPSQEQPSTNAQRELQQIWSRILDLPTDLIGLDDGFFSLGGDSVSAMKVVGEARKAGIELAVADIFTHRTLRLIADNSKSIKREGDQTVANIIPPFSLIGNEVDIEALRQNISTQCDIDTSKVQDAYPCTPLQEGLISLASKRPGDYVMQAVLELSSEVSITKFQAAWEETTKTIDVLRTRIVHCQGYEKLGLLQVILDSSVNWINATGLESYLQADRKQVMGLNDPLARYALVYDGQTDRPRWFVWTVHHAIYDGWSLPLVLDTVAKAYQGETNAGSQSLTGASGFQPFIKYLEEQQRNPEGVKKTEDYWKRYFDSCEATQFPTLPSPSYEPTSNKTTLYRMKVNSPSSSTSLNLTPSTIIRAAWALVVGQMTNTSDVVFGTTVSGRNAPVQTIEMMPAPTLATVPLRVKWTSGQAILGYLETVQREATEMIAFEQTGLHRIAKMSSDARQACQFQTLLVIQSQGHDEDESTGSLVQNELGSSPFGEWVNQDQNEWFNPYALMIEAQPGSQGDSFTLTANYDEKTIQEWIVLKLLKRLELVIQAFMAESYGQGQMVSKTIDELGGSIMTEDDLEQIWTWNQSTPEAVDKYVHEMVEERVREQPNAPAVHAWDGRLTYKELDQLAEKMAAQLLSSIDTGARLSSPRVIPLCFTKSMWTSVAMYGVLKAGGAFVLLDPMVPEQRLKTIVEQVGADVVLSSESEADLAKRLCPHVIQVGLSLSTGPSPTTQRLKGSQRHLSPHAPMFAVFTSGSTGVPKGVLLSHRNFASEIKHHSHLLGFHKNSRVFDFASHAFDAAVHNVFATFANGACLCVPSEKDRKNNIGGVMASMRVTVADLTPTVARLLDPTTLPDIETMILAGEAVSAEDAARWWRDSTRVVNGYGPSECTVMSTINAYPTSPEDASSIGLGAGHTTWVVDPNNHNILVAPGCIGELLLEGPLVGQGYLNDPAKTAASFIEDPTWLLKGSSTRPGRRGRLYKSGDLVKYREDGRFWFMGRKDSQVKIRGQRIELEEVERQVQASWSGDDISQIAAEVIKPQGQGSKPMLAAFIVSKDHQLSDDGPPEKAVKPVPVDPEIEARLAERLPAAMVPSVFFFYMRSHLPQTATGKTHRKLLREIGSSFSFQHLAEVANQVQDDENETKARRPPTTPLECQMQAIWVRILGISPDRISLDDSFIRLGGDSIAAMKVVGEARKHGSLDITVADLLRRPKLCDIIATMTKNKATGASRRLPRDDDEPIPHTKYAGPVDQSYAQGRLWFLDRLYPGLTWCLMPFTARFRGILRLDALHIALQAVENRHEALRTTFMSRDNVDLQEIHPFIPRELKLVELPRGAKGEESLQRALFKERTTPLDLSTETGWRVTVYRLGPEEENHHVLSILMHHIISDGWSLNVLRRELDIFYAAAVNSLDPLSQIDPLPIQYRDYASWQKQRFHQDEYQRQLDYWVSQLQTSRPAEFLCDKPRPDTLSGGAGVHEFTIANTMYDRLQKFCAEAEVTPFVVLLAAFRATHFRLTGVDDATIGTANANRDRWEVKELIGFFVNLQCLRIKMEQGVSFEDLVQQVQETAAASFDNQHVPFEKIVSQLNTPRDLSRHPLVQVIFALHSRGTSGPVKLGDDLESEMLDPIPTSQFDLEFHVFDDGDCLTANVVYSQDLFETETINSMVSVFNNLLDRALSEPKTAISSLPLLTEDGRLKLETWGLTKIDRTNYPRDSSIVDLFKEQVSRHPNRVAVKGNSSSQLTYAELDRKSDTLARWLLKQQPEFAPESMIGVMAHRSCEEIIALFGILKANMAHLPLNHNTPTGRVETILSAIQGPKRLLLLGQDVAPPAVNLDNIEMVRIADTLEEEAPRSWWKRAVVQALPRPKPTSLAYVLFTSGSTGKPKGVMVEHRGVSRLCRDNNIIRHLPSSGGFGHFLNISFDGSSLEVYFAILNGLTLVCVDEITILDAIALQGVFERENVRAVLFTPALLKQILRVNPTTLGTLDLLCVGGDRLDPADCVKAYKHTAQGAKVLNLYGPTENSVVSTVFCYEGQDEGFATGTAPIGEPISNSGALVMDSQQRLVPLGVIGEIVVTGDGVARGYTDPSRDVDRFIRLDGGKGERAYRTGDYARWRPVDGKIEFMGRMDVQVKIRGHRVELGEIEHAIRGHEAVHDVVVLAYRDEKDGGEPRLVGFVTLHDTSKEDVEVKEVEHKDGEGETKQHVHQELEARLRANLPTYMIPQTITILERMPLNASGKVDRVALSLTITPKTKARAAGVALRKPTTDMEVALRKIWAQVLDLDPETIGLDDNFFDIGGHSILAMRAVSEARKVDIELTVADIFRSKCLEALARRQEEIVGGPNTEEEEEVELIDSNTKAALLKDLDSLKATIHSTQVEDMLPLTSMQEHYVTTGVASGEYAHYFYLDLGANPDVSRIEKACRLTLAKIPILRASFMRLLGQHWQVIPRDVPARLQTVNTIHVNGDLDRAADDFCLRNWDNISAAEPPALFTLLKHRTQGTRLVIRLSHAQYDGVCFPPIVRAIIEGYTTGDVTPLPSFTKFLSGAARQRPQSLEYWSRLLRGSSLTTILPRLRLSNSSRALTPPRPIAAELDVALPQRLPSSITPAIVASAAWSILLSQISGKQDVVFGHVVAGRNSSISRIDEIVGPCLNLVPVRATLTESLTATELLQSLQTQFFTMGSADSVGFKDIMHESSNWPSNSDFESVLHHANVDEHPEFDFDGIKMKLHFFTNPRLIVSRLALASYPTKGGECLQFRLTASTDKLSDVQAKMLLDALCKIIRGFGESANVPVLSWIGQVGLRLSFTLMDYSSFPL
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of sansalvamide, a cyclic pentadepsipeptide that shows promising results as potential anti-cancer drug (PubMed:26936154).  The nonribosmal peptide synthetase NRPS30 produces sansalvamide by incorporating successively one phenylalanine, one leucine, one alpha-hydroxyisocaproic acid (HICA), one valine and one leucine before sansalvamide is released from by cyclization by the terminal C domain of NRPS30 (PubMed:26936154).  The HICA residue is probably provided by reduction of alpha-ketoisocaproate by the cluster-specific aldo-keto reductase (NECHADRAFT_45914) (Probable).
What are the official names of this protein?
Nonribosomal peptide synthetase 30, Sansalvamide biosynthesis cluster protein NRPS30.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.