PharMolix/UniProtQA huggingface dataset:
Protein: IF2_CHLTA
Sequence: MEKVKLTKNLKLKIKNAQLTKAAGLDKLKQKLAQAGSSDTKNSPASKAQTKEKSSKKTAGTPAPAPEVDSGATESTARRIRAKDRSSFAAEPTVTTALPGDASHLTLDAIPAMKAPEITSVTQKEQTLGECTDTSSVQQEEKKESSEETSPERVEETLIIRTRTEPKSVVSIKPKFGPTGKHINHLLAKTFKAPAKETKAASTEETTQQQPRQNDAASYNNKQQPSGTSSRPASSAPSYRRESTNNNNNAKRGSERDRSKRSDESVKAFTGRDRYGLNEGSSEEDKWRKKRVHKTKKQAEEHVVQCPAHIKIALPITVKDLAAEMKLKASELIQKLFIHGMTYVVNDVLDSQTVVEYIGLEFGCTIEIDSSAKEKLCLLENAVRDEVNATDPEKLIIRSPIVAFMGHVDHGKTTIIDALRQSNMAASEAGAITQHTGAFKCTTPVGEITVLDTPGHEAFSAMRARGAEVCDIVVLVVAGDEGIKEQTIEAIEHAKGANITIVVAINKCDKPNFNVETVYRQLAELDLLPEAWGGSIATINTSAKTGEGLQDLLEMLALQAEVLELKADPSARARGLVIESELHKGLGAVATVLVQNGTLHLGEALVFNDCYGKVKTMHDEHNQLLQSATPSTPVLITGLSAIPKAGDPFIVVKNEKVAKEIISARLAGQQRSAALQKKRPNFDAVLQNKKTLKLIIKADVQGSIEALAHSILNIRSEKVDVEILSSEVGDISESDIRLASASKATVIGFHTSVESHAEPLIKNLNVKVCLFDIIYHAVDAIKEIMTGLLDPIAEEKNLGAAEIKATFKSSQLGTIYGCLVTEGTIVRNQKIRIIRDKEVLWKGSLSSLKRLKEDVKEVKKGMECGILLDNYQQAQVGDILQCYEVIYHPQKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_HELMI
Sequence: MLHIRIVAVGKLKEKYLKEGLREYIKRLGAYSRLEIIEVPDEKVPDKPSDTEAALIKRKEGDRLLAAAGDKDYIGVALDPRGEMWSTEDLADKMRRWELYGPNLVVFFIGGTLGLSKEVHAVCKAKWSLSRLTFPHQLVRLILLEQVYRGCKVNRGETYHR
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIFSL_ASFWA
Sequence: MASILTLDGLYAEVPKFLPEALREGCAGKNPLSFYIQQILNLMGCDGNEYHVLFTSSSEEANTHMIMAAVRRHLLRTRQRPHVIIGAAEPPSVTECVKALAQEKRCVYTIIPLKNFEIDPVAVYDAIQSNTCLACISGTNAVVKTFNKLQDISKVLRGIPLHSEVSDLVYQGCIKQNPPADSFSINSLYGFLGVGVLGMKKKVMQGLGPLIFGGGLRGGSPNIPGIHAMYRTLTQQRPSMKKINTIHKLFMKTLKKHQHIYLPIGGVSAEDMSAENSAKDIPSTDVPVGPKGLPGYILFSVGHRAEELQKKIFTKFNIKVGRIVDLQEILFRIKIPQKYWETLLFIQLRDNLTKEDIKRVMVVLMHLDTITPRGSLPPPSYSSSFS
What are the official names of this protein?
NifS-like protein.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Virion.
Protein: TRPA_NEOYE
Sequence: MNTISSVFENLDKQCALIPFITAGDPDLVSTGKALQILDSYGADIIELGLPYSDPLADGPIIQEASNRALKQGINLNKILSMVKTVNMTIKAPIVLFTYYNPVLHLGINNFIYAISNAGIRGLLIPDLPIEESEYVISVCNLFNIELILLLAPTSSRERISKIIKRAPGCIYLVSTTGVTGQKSQLTSQLKELTETVKTMTNKSIILGFGISTTEQIKEIKGWNINGIVIGSAFVKRLSGNVPEAGLEQIQSFCQDAKNAIIS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MNMA_PORG3
Sequence: MDVAALVSGGVDSSVVVHRLCEEGYKPAIFYIRIGMEDEDGYIDCPAEEDIELTTLIARRYGCPFEVVDLHKEYWERVVSYTVETVRRGLTPNPDMMCNKLIKFGCFEERWGYQFDRIATGHYATTDLLNGKTYLSTAKDPVKDQTDFLAQINFAQISKLMFPIGHLLKSEVRAIANAAGLPSAKRKDSQGICFLGKIDYNDFIERYLGKKEGRIIELETGKVIGRHQGYWFHTIGQRKGLGLSGGPWFVVKKDIKRNIILVSRGYDPDTQYGKTIEMETFDFITEDAYEAGYWNREDATPVTFKIRHTPEFTRGLLYKGEKGYRLESEERIQGIAPGQYCVIYDEDHHLCYGSGMITKGR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CADH1_RAT
Sequence: MGARCRSFSALLLLLQVSSWLCQQPESESDSCRPGFSSEVYTFLVPERHLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSFLVHAWDSSYRKLSTKVTLKSLGHHHHRHHHRDPVSESNPELLTFPSFHQGLRRQKRDWVIPPINCPENQKGEFPQRLVQIKSNRDKETTVFYSITGPGADKPPVGVFIIERETGWLKVTQPLDREAIDKYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNRPEFIQEVFEGSVAEGALPGTSVMQVSATDADDDINTYNAAIAYTILSQDPELPHKNMFTVNRDTGVISVVTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPIFNPSTYQGQVLENEVGARIATLKVTDDDAPNTPAWNAVYTVVNDPDHQFTVITDPKTNEGILKTAKGLDFEAKQQYILHVTVENEEPFEGSLVPSTATVTVDVVDVNEAPIFVPAEKRVEVPEDFGVGLEIASYTAREPDTFMEQKITYRIWRDTANWLEINPETGVISTRAEMDREDSEHVKNSTYTALIIATDDGSPIATGTGTLLLVLSDVNDNAPIPEPRNMQFCQRNPKPHVITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAEQESLILQPRKDLEIGEYKINLKLSDNQNKDQVTTLEVHVCDCEGTVNNCMKAISLEAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVIRNDVAPTLMSMPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEED
What is the function of this protein?
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors.  Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
What are the official names of this protein?
Cadherin-1, Epithelial cadherin, E-cadherin, Uvomorulin.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell- cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity).
Protein: SYM_HYPBU
Sequence: MGRWIVASAWPYVNSIPHLGNLIGSILSADVFARYLRLKGEDVVFVSGSDEHGTPIEVEAIRRGVHPKQLTDQAHEYVKKLFEEFRISFDNYTRTENPVHKEFVREFMMKLYQNGYIFEQDDVLPYCPRDKMFLPDRFVVGTCPYCGFEKAYGDQCDNCGRLLHPTELKNPRCSICGGPVEFRKSKHWFFNLPKLQEKVEKWLRESNLPPNVKNYSLNMLKEGLKPRSVTRDNKWGIPAPFPGAEGKTIYVWFDALLGYISATKEYGLKKGDPELWKKYWFNPETKTVYFIGKDNIPFHAIILPAMLIGSGDPYVLPSYISATEYLMYEGEQFSKSRRWGIWIDEALEILPADYWRFALIRMRPEAKDTNFTWSEFLRIVNTEMNDDIGNYVHRVLRFIESKFGSVVPEPGSYSDADKEFEKAIRETPRRAEKYFEEVRLKQALGEVIELARKGNQYLNTKAPWDKIKTDPKDAATTMYLAVNSVATLAILLAPFTPDSAERLWKMLNLPGSVHEPGRWKQAGEMIIKPGHRIGKPEQLFRKLPARFDKEIASKLQEIRRKVMEKRPPLLRW
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APBLC_ARATH
Sequence: MSGHDSKYFSTTKKGEIPELKEELNSQYKDKRKDAVKKVIAAMTVGKDVSSLFTDVVNCMQTENLELKKLVYLYLINYAKSQPDLAILAVNTFVKDSQDPNPLIRALAVRTMGCIRVDKITEYLCDPLQKCLKDDDPYVRKTAAICVAKLFDINAELVEDRGFLEALKDLISDNNPMVVANAVAALAEIQENSTSPIFEINSTILTKLLTALNECTEWGQVFILDALSRYKASDPREAENIVERVTPRLQHANCAVVLSAVKMILQQMELITSTDVIRNLCKKMAPPLVTLLSAEPEIQYVALRNINLIVQKRPTILAHEIKVFFCKYNDPIYVKMEKLEIMIKLASDRNIDQVLLEFKEYATEVDVDFVRKAVRAIGRCAIKLERAAERCISVLLELIKIKVNYVVQEAIIVIKDIFRRYPNTYESIIATLCESLDTLDEPEAKASMIWIIGEYAERIDNADELLESFLENFPEEPAQVQLQLLTATVKLFLKKPTEGPQQMIQVVLNNATVETDNPDLRDRAYIYWRLLSTDPEAAKDVVLAEKPVITDDSNQLDPSLLDELLANISTLSSVYHKPPEAFVTRLKTTVQKTEDEDYVEGSETGYPEASGNPVDGAASPSATTGYVTKLAAAPAPVPDLLGDLMGSDNAAIVPVDEPTTPSGRPLPVVLPASKGQGLQISAQLTRQDGQVFYSMLLENNSQSLLDGFMIQFNKNSFGLAAVGSLQVPPLQPGASARTMMPMVLSQNMSTGSTSSVLQVAVKNNQQPVWYFEDKIVLNALFSEDGRMERGTFLETWKSLPDSNEVQKEFPGITITSVESTLDLLAASNMFFIAKRKNGNQDVLYLSAKVPRGIPFLIELTAIVGQPGLKCAVKTPTPEIAPLFFEAVEILFKA
What is the function of this protein?
Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes.  The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).
What are the official names of this protein?
Beta-adaptin-like protein C, At-bC-Ad, At-betaC-Ad, AP complex subunit beta-C, Adaptor protein complex AP subunit beta-C, Beta-adaptin C, Clathrin assembly protein complex beta large chain C.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the trans-Golgi network. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity).
Protein: YACG_LEGPC
Sequence: MNNQKKIKCPICGKQNTWRPDNQFRPFCSERCKLIDLGEWASESRKIPGSSIDPESIVTTNNKQDNVDEQ
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: 3SX1_DENPO
Sequence: MKTLLLTLLVVTIVCLDLGYSLKCYQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK
What is the function of this protein?
This three-finger toxin inhibits ASIC channels.  It acts as a gating modifier toxin by decreasing the apparent proton sensitivity of activation and by slightly increasing the apparent proton sensitivity for inactivation (PubMed:23034652).  It binds more tightly to the closed state and to a much lesser extent the inactivated/desensitized state of ASIC1a isoform of ASIC1 (PubMed:23034652).  It interacts directly with the outside surface of the thumb domain of chicken ASIC1a (ASIC1a), but does not insert into the acidic pocket as suggested for mambalgin-2 (PubMed:29872539).  This binding leads to relocation of the thumb domain that could disrupt the acidic pocket of cASIC1a (PubMed:29872539).  It reversibly inhibits rat ASIC1a (IC(50)=3. 4-55 nM), rat ASIC1a-ASIC2b (IC(50)=61 nM), rat ASIC1a-ASIC1b (IC(50)=72 nM), human ASIC1a (IC(50)=127-580 nM), chicken ASIC1a (IC(50)=123. 6 nM), rat ASIC1b (IC(50)=22. 2-203 nM), rat ASIC1a-ASIC2a (IC(50)=152-252 nM) (PubMed:23034652, PubMed:23624383, PubMed:25873388, PubMed:24619065, PubMed:26680001, PubMed:29872539).  In vivo, it shows a potent naloxone-resistant analgesic effect against acute and inflammatory pain upon central and peripheral injection (PubMed:23034652).  In addition, it also has an opioid-independent effect on both thermal and mechanical inflammatory pain after systemic administration and is effective against neuropathic pain (PubMed:26680001).
What are the official names of this protein?
Mambalgin-1, Mamb-1, Pi-Dp1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Mambalgin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: INI1_SCHPO
Sequence: MSKHHPDLVLCRRQPGITVGKLCERCDEKCPICDSHVRPTTLVRICDECAFGSSQDRCIICGAPGVSDCYYCSECTRMEYDRDGCPRVINLGSSRTDWFYERKKFKNAGKEMPGATY
What is the function of this protein?
Required for pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor ini1.
What is the protein family that this protein belongs to?
Belongs to the PHF5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFG_AERS4
Sequence: MARTTPIERYRNIGISAHIDAGKTTTTERVLFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMGKQFQPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRTGANYLRCVEHIKTRLKGTPVPLQLNIGSEENFKGVIDLVKMKAINWSEADQGVSFDYEEIPAELLEQAQEMRMSLVEAAAEASEDLMEKYLGGEELTEEEIKKALRLRVLNNEIILVTCGSAFKNKGVQAMLDAVVDYLPAPTDVAAIDGLKLDGVTKDERHASDDEPFAALAFKIATDPFVGNLTFFRVYSGVVNSGDSVLNSVKEKRERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDEKSPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAQEDPSFRVWTDEESGQTIIAGMGELHLDIIVDRMRREFKVEANVGKPQVAYRETIRETVKDVEGKHAKQSGGRGQYGHVVIDMYPLEAGKAYEFVNDIKGGVIPGEYIPGVDKGIREQLKSGPLAGYPVMDLGVRLHFGSYHDVDSSELAFKIAASMAFKSGYMKANPVLLEPIMKVEVETPEDYMGDVIGDLNRRRGLIEGMEDGPSGKIVRALVPLAEMFGYATALRSATQGRASYAMEFAKYSDAPNNVAQAVIEERKSK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_DEIRA
Sequence: MTLSKTPPRIERFGDITEVIPLPNLTEVQVNSFKAFLQDDKAPDQREDVGLQSAFREVFPIDESEKGRSTGMVLDFIEYRLGEPEYSPEECREKDLTYEAPLYVKLELIHKDTGVIKGFKPDSPPESWVFLGNLPLMTFDGSFIINGADRVVISQIHRSPGVYFTSSYKGIKKQYTAAIIPMPKRGPWIELEFAGDVLEMKVNKRKFPVSLLLRVLGMDDASIRALFTEFTPEVEPGEDKSAGMGADEALLRLFTVLRPGDPPKRDKAIQYLFGLLADPRRYDLGEPGRFKMNTKLGVQRQERTLLKFEDGKFSDAGLVDTIRYLMALQQGLETVPMVDEDGVVTDVPVAEDDIDHLGNRRVRTVGELLADQLRVGMGRMARGVRERMLLGNPDAATPTKLVNNRPIVAAMREFFGRSQLSQFKDQTNPLSDLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICPIETPEGANIGLISSLSSYAKVNDLGFIMAPYRKVEDGKVTNQVEYMTADIEDRYTIAQANSPLNEDNTFADERVLARRKGDPLLYTPDEVDYMDVSPKQIVSINTSLIPFLEHDDANRALMGSNMQSQAVPLVRADSPAVGTGVERRVVTDSGTSVVSDVNGRVSYVDARAIQVTLSEDHRELNMNAGNVRTFELIRFTRSNQGTNLDQHPIVSVGDEVKVGQVIADGPASERGRLALGQNITIAIMPFDGFNFEDAICINEDLVRQDFYTSVHIEKDEIEARDTKLGPEKITRDIPGLSEAALRDLDEDGIVRVGAEVKPGDILVGKTSFKGESEPTPEERLLRSIFGEKAREVKDTSLRVQSGQGGIVVKTVRFRRGDEGVDLKPGVREMVRVYVAQKRQLQVGDKVANRHGNKGVVSKIVRPEDMPYLEDGTPVDIVFNPLGVPSRMNLGQILETHLGEVARLTGQKFETPVFDSVTEATIKEMLEVAAAERLQARKDDGFELDKREQEVLDRAGKLGVIDAPGDDYEKGQMQLARTGKSILYDGRTGEPISGPVVVGIMYVMKLYHMVEDKLHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHVLQEMLTIKSDDIDGRDAAYQSIVKGEEVSGSTIPESFKVLVKELHSLGLDVEVLDHGDKAVDIFEGMMPKR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PTBP1_BOVIN
Sequence: MDGIVPDIAVGTKRGSDELFSACVTNGPFIMSGTSASTANGNDSKKFKGDSRSAGVPSRVIHIRKLPGDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMHTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGAPGIMSASPYAGAGFPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAAAGRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKVLFNKKENALVQMADGSQAQLAMSHLNGHKLHGKPVRITLSKHQSVQLPREGQEDQGLTKDYGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSISEDDLKILFSSNGGIVKGFKFFQKDRKMALIQMGSVEEAIQALIDLHNHDLGENHHLRVSFSKSTI
What is the function of this protein?
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events.  Activates exon skipping of its own pre-mRNA during muscle cell differentiation.  Binds to the polypyrimidine tract of introns.  May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA.  May promote the binding of U2 snRNP to pre-mRNA.  Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.  Represses the splicing of MAPT/Tau exon 10.  Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9.  Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.
What are the official names of this protein?
Polypyrimidine tract-binding protein 1, PTB.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU2M_EIDHE
Sequence: MNPLTFAMILLTIMLGTTIVMTSSHWLVVWIGFEMNMLAVIPVLMKKYNPRSMEAATKYFLTQATASMLLMLAIVINLIYSGQWSTTNPLNPTASIIMTLALAMKLGLAPFHFWVPEVTQGIQLSSGLILLTWQKLAPISILYQISSTTNLNLLLAMSILSVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAIMVYNPTMALLNLVIYILLTTTTFSVFMLNSSTTTLSLSHMWNKTPLLTTALLMTMLSLGGLPPLSGFLPKWMIIQELTKNNSVIVPTTMAITALLNLYFYMRLTYSTSLTTFPSTNNMKIKWQLNNTKPTIHLSPLIILSTLILPLSPILTLLE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PXDC1_BOVIN
Sequence: MASAVFEGTSLVNMFVRGCWVNGIRRLVVSRRGDEEEFFEIRTEWSDRSVLYLHRSLADLGRLWQRLRDAFPEDRPELVRAPLRQGLIAIKDAHDIETRLNEVEKLLKAIISMPRKYSRSEVVLTFFERSPLDQVLKNDNVHKIQCGFQSPVKISEIMRSNGFCLANTETIVIDHSIPNGKDQHGAVDPAEHLFEGGGELPAELEDGDDPAAYVTNLSYYHLVPFETDILD
What are the official names of this protein?
PX domain-containing protein 1.
Protein: ATPE_BACC7
Sequence: MKTFPVSIVTPDGPVYEKEVEMVSVKAESGEMGILPGHIPTVAPLKISAVRLKNGGHTDYVAVSGGFIEVRPDKVTVLSSSAEEANHIDIHRANEAKRRAEQRLQDKQAHVDFKRAEMALQRAVNRLNVSDMK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PATN_PENEN
Sequence: MVLTTGLKGAHVLITGGTRGMGEAMVHKFLQEEANVSYCARTVTNTEYDDFYSTLAEGNTARAVGTAFDVASKDSLVKWVESSAERLGRIDVIIANASPMHMEGETEHWESSFAIDVMGFVELVKAATPYLEKSPQASIIVQSSFMGREFYRSPPAAYGPCKAAQLQHVQELSHFLGPKGIRVNAISPGPVLCKGGPWELYSKINPEWVEEQRLKIPLKRLGGPTEVANVAVFLASPLASFVSGTNMLVDGGIHVGTQF
What is the function of this protein?
Isoepoxydon dehydrogenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:30100914, PubMed:25625822, PubMed:30680886).  PatN catalyzes the conversion of isoepoxydon into phyllostine (PubMed:30680886).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units.  The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol).  These first reactions occur in the cytosol.  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI.  The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole.  PatN catalyzes then the transformation of isoepoxydon into phyllostine.  The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol.  The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM.  Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (PubMed:30680886) (Probable).
What are the official names of this protein?
Isoepoxydon dehydrogenase patN, IDH, Patulin biosynthesis cluster protein N.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: GLGE2_STRCO
Sequence: MRMSATVGIGRIPVRDVQPVVEYGRRPAKAVTGETFEVTATVFREGHDAVAANVVLKDPEGRPGPWTPMRELAPGSDRWGATVTPGAPGNWTYRVEAWSDPVATWRHAARIKVPAGIDAGLVLEEGSELYRRAAAGVPKDSGRDVLLAAATALLDDTLPVATRLAAALTPQVDAVLARHPLRDLVTSSDPLPLLVERERALYGAWYEFFPRSEGTPHTPHGTFRTAARRLPAIAAMGFDVVYLPPIHPIGTTHRKGRNNTLSATGDDVGVPWAIGSPEGGHDSIHPALGTLDDFDHFVTEAARHGLEIALDFALQCSPDHPWVHKHPEWFHHRPDGTIAHAENPPKKYQDIYPIAFDADPDGLATETVRILRHWMDHGVRIFRVDNPHTKPVAFWERVIADINGTDPDVIFLAEAFTRPAMMATLAQIGFQQSYTYFTWRNTKQELTEYLEELSGEAAAYMRPNFFANTPDILHAYLQHGGRPAFEVRAVLAATLSPTWGIYSGYELCENTPLREGSEEYLDSEKYQLKPRDWTRAAREGTTIAPLVTRLNTIRREHPALHRLRNLRFHHTDNDALIAYSKRVGSDVVLVVANLDPHRTQEATISLDMPQLGLDWHDSVPVHDELTGRTYHWGRANYVRLEPGRAPAHVFHVRRPSAAAAPQNGGSGAS
What is the function of this protein?
Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans.  Maltooligosaccharides with a degree of polymerization (DP) superior or equal to 4 are efficient acceptors, with DP6 being optimal in the GlgE-catalyzed polymerization with M1P.  Is probably involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.
What are the official names of this protein?
Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 2, GMPMT 2, (1->4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
Protein: TRPD_STUS1
Sequence: MDIKEALNRIVGQLDLTTEEMQAVMRQIMTGQCTDAQVGAFLMGMRMKSETIDEIVGAVQVMRELAAPVRFDTDKLVDTCGTGGDGMNIFNVSTAASFVVAAAGGKVAKHGNRAVSGKSGSADLLEAAGVFLDLTPEQVARSVDTVGVGFMFAPAHHGAMKYAAGPRRELGLRTLFNILGPMANPAGVRHQVLGVFSKALCRPMAEVLSRLGSKHVLVVHAQDGLDEISLAAPTHVAELKDGEIREYSIQPEDFGIKSQSLIGLNVEDAQGSLALIRDALGRRKSENGQKAADMIVLNAGAALYAADVATTLKQGVEMAHDALCSGIARDKLEELVSFTAVFKQENQK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: AROE_SHESR
Sequence: MTDMPSVTTPALDRYAVFGNPIGHSKSPFIHGQFASITQQPLSYEAILAPIDGFEASLRAFFQAGGKGANVTVPFKEQAFALCDSLSAEATLAGAVNTLSLLADGTIYGDNTDGLGLVADLIRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVITNRTQSKAQALVEIFSQVQQGRYSDKLQSMPMPELSGEFDLVINSTSASLAGELPPLPQSIIGNKTACYDMMYGAKPTAFNQWAVQQDAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQADAQ
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.