Protein: FRBB_BLOB1
Sequence: MRNIDEHMSERATLQSSGGYGERDSGVEPIAIIGMSCRLPGEASDPKGLWELLASGKSAWSKVPKDRFNMDAFHDPSNPTAGTTNTAGGHFIEEDLAAFDADFFGMNPVELEALDPQQRLLMEIAYESFENAGLPMKQLWGSNTGVYVGQWSNDYDQNLARDTEFPALYHTIGAGPAISSNRLSYFFNLRGPSFTVDTGCSASLVALHSAVQSLRAGETDASFVGGVNLLLDPQRFSYQSKLKMFSAQGRSYSFDHRANGYGRGEGCCGLVLKRLSAAKRDGDPIRAVIRNSVLNQDGRTPGISVPSGLAQEQAIKAAYSGARLHDGPDFVEAHGTGTAVGDPIEVKAIAAAFATIKTRDGQPIPVGSVKGNVGHTESCAGLAGVIKAVLMLENQTIPPQANFERLNPSLLLDEWNLYVPTVLEQRELRRISVNSFGYGGTNAHVILDRADAPTDQKRDSIFLGLDSAPQPKRKRLLILSATSEEGCSKVAQSLVDYVDQRFDSAATEAWLDRLAYTVNRKSIHSHRTTILASDLEEMLHQLSRVVQVPTPARVDVKSPKVAYVFSGQGAQYYNMGRELINTWPVFTKSLQRANQQLNTLGCEWDLMAELSRDAESSNLDNPAFGQPASTAIQLALCDTLADLGVVPVSVAGHSSGEIAAAYAAHALSFENAMTVSYHRGRLTAALVSKQTSPAGAMLAVGTSPDVAQEYIDSIDGPSSRVTIACYNSPSSVTLSGDIEGIEKLQQMFENKKIFNRLLRTNGAAYHSHHMQQIEEEYRNALEGVEATTAKIPLISSVTGRDSGSEVFGRDYWVENLVSPVRFDEATAQLCQDISLILELGAHETLGGPIRQTLKTLGPDARDVRYLSCLKRKSDAASTLLTTIGEVFADGIHVDLHTANNGFDKKLPRPLSDLPRYPFDHSRRYWHESRVSKEYKHRKFLPHELLGNMSTDVNHLEPKWRRYLKLKEIPWLRNHVVQGQIVFPAAGYLSMALEAVRRYTLSADPEAKISSYAYRNISFGKALVLSDEKLDNEITLSLIPESRTAKESWHDWVEFRIHTVSAGKPWTEHCRGRIRAVLDDSNEDHIEATADKRVVEQALSQSVRFVSPSAFYNLSRQNGLDWHKPFDNLVKIRASRETSVTVTESPRLERDDSLHNDSPYVIHPGTLDTALFHCVCAIVYSQKKIDVPVVPSFISELVIAGNARHAPGTRLVSHAIEVDNGEAHDVVINSAVDGHDQFLIRARGMILAKLPGGTSRSGSRKLTHESTWVPYCQKLTTQHLDRICKKDLPDGSAVEQNDMLNSLTVAFCRAAIEKVSYEQVREGYQQHFYRWMKKIVDGSMLESTPEPFMNGHLTNGLTNGITSNGTKHIPNGLSNGISKHQVNGIANGLPQDASNHIAQKHPDASSLTPKENALKVLTNGLSKDLPNGVSGKHDEFEILKSSSASPGEAAVRRVGENAASILTGEIDPISLLLHDGLLPKMYAEFRNQRCYHQIKAYIAELGLQNPSLRIIEIGGGSASASLPILQACNRDGQSSIAKYDFTDISSGFFLDARKTLADYSEIVDFHVLDIEQDASQQGIEKGSYDIVIACNVIHATVDIDVSLANAKGLLRPNGRLILMEITNPQPYYSLIFGAFPGWWAGAESGRVESPLLRGEQWSEKLIKHGFVDTEPVFRDFEEKQGGTLGVFATTMAEDVSERKPIAHINIVGLPTAPNAWSATDLARVLGKSSEISYIDLNDKSALLAPLRDAVIFLPEICDALTKSITEESFEALQRQIIGSNIVLMLGRGGAIDPSLPNGSLTTGFARTIRLEHPKVRFITLDLDPQSPYESSLTVVNEVLRSPVTDLSKPSADLECEFAERNGQLFVSRVVAEEKAEHYIKNATGKSILHDRNFLSPRNAMRAGLGIVGLLETFHWKPDPGMDGPLGPDQVRVELRAASINFRDILVATGQVQSLTEMKNDCSGVVVESGENMKSRFKPGDRVCAYYGQSYSNFPVVDGDCCSRIPDSMSFEVAASVPIVWGTVYHSLVDIAHLAEGEKILIHSGAGAVGQAAIALAQHLGAEVFTTAGSDQKRAMLAEKFNLPNDHIFSSRNTHFKQGIKELTKGQGVDVILNSLTGEMTRASCEVLTDFGRFIEIGKKDLIDDALLPTKFLLRNITFACVDLTQIIEKRHKQARRLLEKVVDLLASDAVKATEITTYPISEIEHAFRFVASGKHIGKVILTVAQDEVVKVSSASEYLTKSYTDLVQAASAPPQLAQLQTDAVYIVVGGLGGLGRCVVPWLADRGARTIVTLSRSGASSEQATTLIEEMQSRGVSVVAKACDIGSKESLRGVVEDIKGSLSLPIRGLINSAMSLQDVTFKDMTHEQWQKSLLPKVQGTWNLHECLPKDLDFFISMSSIVAISGNLGQSNYGAACSFQDSFAAFRRAQGLSGYSINIGPVSDAGFVSENEQVNMGMERKGFSSVTIAEVLANLDYVVTSAGNRTQNSIGLLPARPDASRSTWLQNKRLIHLAQHSGPRGEGEGGKSDEAQDALEAVGNATTAEGAEAAVLTAILQQLSKLLMTPVEQLSPRRTLDSYGVDSLIAVELKNWIGTYLEADIPLLVLRETNDIQHLARLAAEESRLVSLA
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the antifungal antibiotic FR901469, an inhibitor of beta-1,3-glucansynthase, exerting antifungal activity against the pathogenes Candida albicans and Aspergillus fumigatus (PubMed:27660098).  FR901469 is a cyclic depsipeptide containing 12 amino acid residues and a fatty acid chain (PubMed:27660098).  The NRPS frbI contains 12 modules responsible for the formation of the depsipeptide backbone which is denoted as Acyl-Thr-Ala-Tyr-Val-4OHPro-Thr-Thr-3OHPro-threo3OHGln-Gly-Thr-Orn-OH (C71H116N14O23) (Probable).  The PKS frbB is probably involved in the production of the hydrocarbon chain, and the acyl-CoA ligase frbC might be involved in the transport of the chain to the peptide ptoduct of frbI (Probable).  Because FR901469 contains 3 hydroxylated amino acid residues, the 3 oxygenases frbA, frbH, and frbJ might be participating in amino acid hydroxylation (Probable).  As no thioesterase domains were detected in frbI or frbB, the thioesterases frbD and frbE may instead release and cyclize the products of the NRPS and PKS, respectively (Probable).
What are the official names of this protein?
Highly reducing polyketide synthase frbB, HR-PKS frbB, FR901469 biosynthesis cluster protein B.