PharMolix/UniProtQA huggingface dataset:
Protein: DSBD_SALTI
Sequence: MAQRIFTLILLLCSTSAFAGLFDAPGRSQFVPADRAFVFDFQQNQHDLTLSWQVKEGYYLYRKQISITPTKADIAAVQLPAGVWHEDEFYGKSEIYRKRLNVPVTVNQAAAGATLTITYQGCADAGFCYPPETKTVPLSEVAAAIDATPTPAVTQTGETSKPAAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGRQRLSTGRALLLAFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLALSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFVMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLVTVFGNRLLPKSGPWMAHVKTAFGFVILALPVFLLERIIGEAWGLRLWSLLGVAFFGWAFITSLQARRAWMRIVQIILLAAALISVRPLQDWAFGSPSAQAPAHLNFTAISTVDELNQALAQAKGKPVMLDFYADWCVACKEFEKYTFSDPRVQQVLGDTVLLQANVTANNAQDVALLKHLQVLGLPTILFFDAQGQEQPQARVTGFMDAATFSAHLHDRQP
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OPGD_SALPK
Sequence: MNRRRFIKGSMAMAAVCGSSGIASLFSQAAFAAESDIADGKIVRFDFAGLQSMAQALAKKPWGGAPGPLPDTLANLTPQAYNSIQYDAAHSLWNGVANRQLDIQFFHVGMGFRRRVRMFSVDTTTHLAREIHFRPELFKYNDAGVDTTQLEGQSDLGFAGFRVFKAPELARRDVVSFLGASYFRAVDDTYQYGLSARGLAIDTYTDGQEEFPDFTAFWFDTAKPGDTTFTVYALLDSASVTGAYKFVIHCEKTQVIMDVENHLYARKDIKQLGIAPMTSMFSCGNNERRVCDTIHPQIHDSDRLAMWRGNGEWICRPLNNPQKLQFNAYMDDNPKGFGLLQLDRDFSHYQDVMDWYNKRPSLWVEPRSKWGKGAVSLMEIPTTGETLDNVVCFWQPEKAIKAGDTLVFNYRLYWSAQPPVQSPLARVMATRTGMGGFPEGWAPGEHYPDKWARRFAIDFVGGDLKAAAPKSIEPVITLSSGEAKQVEILYVEPFDGYRIQFDWYPTSDSTAPVDMRMFLRCQGEAISETWLYQYFPPAPDKRRYVDDRIMR
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ACPS_OENOB
Sequence: MSYRIGIDIESISDVQAAAEKHKQFLDKVLTKSEQKQLAGRKGNGYYAYLAGRFSSKEAYAKATGFGIGSKVNFTDIEILDDENGAPRLSVSGRSLFLNAKSYQISISHKIKLDLVATEVLIEVEDGNSDS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APAG_ECOLC
Sequence: MINSPRVCIQVQSVYIEAQSSPDNERYVFAYTVTIRNLGRAPVQLLGRYWLITNGNGRETEVQGEGVVGVQPLIAPGEEYQYTSGAIIETPLGTMQGHYEMIDENGVPFSIDIPVFRLAVPTLIH
What are the official names of this protein?
Protein ApaG.
Protein: S36A2_HUMAN
Sequence: MSVTKSTEGPQGAVAIKLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPFMDYGDTVMHGLEANPNAWLQNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPNCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYQALDELLKSEDSHPFSNSTTFVR
What is the function of this protein?
Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported.  Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency.  A free carboxyl group is preferred.
What are the official names of this protein?
Proton-coupled amino acid transporter 2, Proton/amino acid transporter 2, Solute carrier family 36 member 2, Transmembrane domain rich protein 1, Tramdorin-1.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Recycling endosome membrane.
Protein: HBB_TURTR
Sequence: VHLTGEEKSAVTALWGKVNVEEVGGEALGRLLVVYPWTQRFFESFGDLSTADAVMKNPNVKKHGQKVLASFGEGLKHLDDLKGTFAALSELHCDKLHVDPENFRLLGNVLVVVLARHFGKEFTPELQSAYQKVVAGVATALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: LEUD_KLEP7
Sequence: MAEKFTQHTGLVVPLDAANVDTDAIIPKQFLQKVTRTGFGAHLFNDWRFLDDKGQQPNPEFVLNYPEYQGASILLARENFGCGSSREHAPWALTDYGFKVVIAPSFADIFYGNSFNNQLLPVTLSDEQVDELFKLVQANPGITFEVDLEAQVVKAGDKTYSFKIDDFRRHCMLNGLDSIGLTLQHEAAISDYERKLPAFMN
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: Y4070_SHEB8
Sequence: MTLGQQAEAHAQRYLEQQGLTFVERNVRYPFGEIDLIMRHKSHWVFVEVKYRSATQYGGALQALSAAQITRIRKAANHYLQLNRLDVPCRFDVIAMEADQIHWLVDAF
What are the official names of this protein?
UPF0102 protein Shew185_4070.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: SELO_PSEA8
Sequence: MKSLDDLDFDNRFARLGGAFSTEVLPDPIAEPRLVVASPAALALLDLPAETSDEALFAELFGGHKLWSEAEPRAMVYSGHQFGSYNPRLGDGRGLLLGEVINQAGEHWDLHLKGAGQTPYSRMGDGRAVLRSSIREFLASEALPALGIPSSRALCVIGSSTPVWREKKESAATLLRLAPSHVRFGHFEYFYYTRQHDQLKQLAAFVLEHHFADCNAAERPYAAMFRQVVERNAELIARWQAYGFCHGVMNTDNMSILGITFDYGPYAFLDDFDANHICNHSDDAGRYSFSNQVPIAHWNLAALAQALTPLVEVDELRASLDLFLPLYQAHYLDLMRRRLGLGVAAENDQALVQELLQRMQGSAVDYSLFFRRLGEETPERALASLRDDFVDREAFDRWAEAYRRRVEEEGGDQESRRRRMHAVNPLYVLRNYLAQQAIEAAEQGDYTEVRLLHQVLSRPFEEQPGMERFTRRPPDWGRHLEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: CARB_GEMAT
Sequence: MPRRSDLHRILVIGSGPIVIGQAAEFDYSGTQAIKALREEGYEVILVNSNPATIMTDPEFADRTYVEPVTPEFVEKVIAKERPDAVLPTMGGQTALNVALALHDSGVLAKYGCELIGANARAIRVAEDRKLFGEAMEKIGLRCPTGRTVTSLEEALSAVEETGFPAIIRPSFTLGGTGGGIAYNREEFETIVRRGLDLSPVHSVLIERSLLGWKEYELEVMRDCADNVVIVCSIENLDPMGVHTGDSITVAPAMTLTDREYQVMRDAAVAIIREIGVDAGGCNIQFAVNPTNGELIVIEMNPRVSRSSALASKATGFPIARIGAKLAVGYTLDEVPNDITKTTPASFEPVLDYVIVKCPRFAFEKFVSSDPGLTTQMKSVGESMAIGRTFKEAFQKALRALETGRSGWTIAERLQDDRLTEGSKEELRGALRRPTPERIFQLKRAMLLGMDTKELYEITAIDPWFLDQLRELIDAEQWYEKLTGVDAVSMRRMKRLGFSDRQLGALRGQSESDARAERWALGVRPSYKMIDTCAGEFPSSTPYLYGNYDEESEAATEGRKKVVILGSGPNRIGQGVEFDYCCVRAVLALREQGYETIMVNSNPETVSTDFDISDKLYFEPLSLEDVLEIVHREQPEGVIVQLGGQTPLKLTRPLEAAGVKILGTSPDAIDAAEDRRRFEAIARELGIEQPANGTATSVDEAVTIAQRIGFPVLVRPSYVLGGRAMEIVHDEVSLRDYFERAARVSEERPVLVDRFLEDAFEADVDALSDGTDVVIGAVMEHIESAGIHSGDSACILPPYLIPAAAVAQMKEHTIAFAKRLGVVGLINVQYAYKDGQVYVIEVNPRASRTAPFVSKAIGVSLPSVAARLMLGETLAEVGFTQEIIPPYISVKEAVFPFNKFREFDPVLGPEMRSTGEVMGIDDDFGAAFMKSQLAADNALPREGTVFFTVSDGDKPTAASLAGKFHSIGFSIMATSGTAAFFREQGIPVTSVLKVHEGRPHGVDKILNGEVQLLVNTPLGKHAQVDDEKLRQAAIANRLPYTTTLTAASAAFEAIAARRTREPVVRSLQEWHEILRAPGAVESATAGSTQPAGVA
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: OTC_NOSP7
Sequence: MAALLGRDLLSLADISSTELQELLQLATQLKSQQLKLQCNKVLGLLFSKASTRTRVSFTVAMYQLGGQVIDLNPNVTQVSRGEPLQDTARVLDRYLDILAIRTFAQQDLETFAHYAKIPVINALTDAEHPCQVLADLLTIQESFNTLAGLTLTYVGDGNNMANSLMLGCALVGMNVRIATPDGYEPDSQIVEQARAIANNKTEVLLTHDPELAAKGSTVLYTDVWASMGQETEADNRMPIFQPYQISEQLLSLAAPEAIVLHCLPAHRGEEITEAVIEGSQSRVWEQAENRLHAQKALLASILGAE
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WECF_SALTY
Sequence: MTVLIHVLGSDIPHHNHTVLRFFNDTLAATSEHAREFMVAGEDNGFTESCPALSLRFYGSKKALAQAVIAKAKANRRQRFFFHGQFNTSLWLALLSGGIKPAQFYWHIWGADLYEVSHGLKFRLFYPLRRIAQGRVGGVFATRGDLSYFARQHPDVRGELLYFPTRMDPSLNAMAKERQRAGKLTILVGNSGDRSNQHIAALRAVYQQFGDTVNVVVPMGYPANNQDYIDEVRQAGLALFSAENLQILSEKMEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQADIPCVLNRDNPFWQDMAEQHLPVLFTTDDLNEQVVREAQRQLASVDKSGITFFSPNYLQPWHNALRIAAGEAE
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AMPA_PSESM
Sequence: MELVVKSVSPETLKTATLVVTINESRVLIGAAQLVDIKSGGAISAVLERGDLAGKSGQTLLLTNLQNIKAERVLLVGIGKDGELSDRQLKKIAGSVLSSLKGLGGSDAVIALDDLSVKNRDTYGKARLFVEALADGEYVFDRFKTQKAEVRPLKKITLLTDKVSVADVERAANHAQAIATGMALTRDLGNLPPNICHPTYLGEEAKALGKAHKNLKVEIHDEKKLAELGMGSFLAVAQGSAQPPRLIVMNYQGGKKGDKPFVLVGKGITFDTGGISIKPAAGMDEMKFDMCGAASVFGTLRAVLELKLPINVVCILACAENMPSGTATRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYAERFKPQAVIDIATLTGACVVALGGHTSGLLGNNDALINQLLDAGKLADDRAWQLPLFDEYQEQLDSPFADIANIGGPKGGTITAACFLSRFTKAYEWAHLDIAGTAWLSGGKDKGATGRPVPLLTQYLLDRAGV
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_HAHCH
Sequence: MDIKAAIAKVVDRKDLTTEEMIEVMQQIMTGQATPAQIGGFLVALRFKSESVGEITGAAQVMRQLASKVDIDDPHLVDTCGTGGDGSNLFNVSTAAAFVVAAAGGKVAKHGNRSVSSRSGSADVLEAAGINLDMTAEQVARAIKEIGVGFLFAPAHHSAMKHAIGPRREMGIRTIFNMLGPLTNPAGVTKQVIGVFNPLLCLPLAEVLQRLGSTHVLVVSAADGLDEISLACETHVAELKDGKISEYTLTPEDAGIMRRSLDGLTVASAEESLTLIEAALTKVTDQTSQKARDIVALNAGAAIYAADLASSFKEGVEMAQDAIGSGLAFAKLKELASFSACFKEEE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RL32_TRIV2
Sequence: MAVPKKKTSKSKRDKRRATWRHKAAVEAQKALSLGKSILTGRSTFVYPTAEEEDEEE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: Y312_MYCPN
Sequence: MKDSALTLKRVRIGKFSESMVEERPTLNLFEKVEFNPVPTALVDQLPTEPLVEATLLEKEAITFVDTYATSEAHDQIATFVLEQSMETEVVEKEAIETAIVAPAPDLVEEKAVLVEEVLVEPTATEAVTTEENQVSTTSVTKIKTKRSNTKKVTSETLVASKSVKTKKLITPNRVSSGNVNITLWQVDKKSTNLTKTKTDLFGKKHQFKGPQLISYKK
What are the official names of this protein?
Uncharacterized protein MPN_312.
Protein: RL21_THEYD
Sequence: MYAIIETGGKQFRVKSGDIVKIEKLNIEPGQEVIFDKVLLFKGNEGLKIGNPYIEGVKVKAEVIDEKKDKKVLVYSPPSKKAIHKLKGHRQWYTKIKIKEIVGG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: CLPX_HAES1
Sequence: MTKEKELHCSFCGKEQKEVDKLIAGTSGYICNECIELCHDMLANADDIEEIDEEFQEEEPKLPTPHEIRAHLDDYVIGQDYAKKVLAVAVYNHYKRLRSEKNTSEVELGKSNILLIGPTGSGKTLLAQTLARMLNVPFAMADATTLTEAGYVGEDVENVLQKLLQNCDYDIEKAQQGIIYIDEIDKITRKSENPSITRDVSGEGVQQALLKLVEGTVASIPPQGGRKHPQQEMLRVDTSKILFICGGAFAGLDKIIEKRTNTGGKGIGFGADVRIDEEKVSLTELFKQVEPDDLMKFGLIPEFIGRLPVIAPLSELDEEALVKILTEPKNALTKQYQVLFSLENIELEFTQEALIAMAKKALARKTGARGLRSIVETLLLDTMYDLPSIENLQKVIVEEETVTENKAPVLKFNS
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: ATPD_PSEA6
Sequence: MSELTTIARPYAKAAFDYAVEQKIIAGWQEMLVFAAQVAQNPDIKNLMSGAVAPESLAEIFNKICGEQLDQHGQNFVKVLAENKRLQALPDIAELFSEFKAEFDKEIEADVTSATELNAKQQADISAALEKRLARKVKLNCSVDPTLIAGVKIKAGDTVIDGSVKSKLNRLTDALQA
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GATA_STRZJ
Sequence: MTFNNKTIEELHNLLVSKEISATELTQATLENIKSREEALNSFVTIAEEQALVQAKAIDEAGIDADNVLSGIPLAVKDNISTDGILTTAASKMLYNYEPIFDATAVANAKTKGMIVVGKTNMDEFAMGGSGETSHYGATKNAWNHSKVPGGSSSGSAAAVASGQVRLSLGSDTGGSIRQPAAFNGIVGLKPTYGTVSRFGLIAFGSSLDQIGPFAPTVKENALLLNAIASEDAKDSTSAPVRIADFTSKIGQDIKGMKIALPKEYLGEGIDPEVKETILNAAKHFEKLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRAEDATNLDEIYVNSRSQGFGEEVKRRIMLGTFSLSSGYYDAYYKKAGQVRTLIIQDFEKVFADYDLILGPTAPSVAYDLDSLNHDPVAMYLADLLTIPVNLAGLPGISIPAGFSQGLPVGLQLIGPKYSEETIYQAAAAFEATTDYHKQQPVIFGGDN
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: Y2523_PSET1
Sequence: MSWFKQLWQNSREKGQYYELQAQKYLVSQGLTAIERNYYCPFGELDVIMKDGNTLVFVEVKFRKNHARGGANYALSIQKQARLKRSIYHYLAAKNLTNQPLRIDYVAITGEPSMHINWLKNVF
What are the official names of this protein?
UPF0102 protein PSHAa2523.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: NFS1_YEAST
Sequence: MLKSTATRSITRLSQVYNVPAATYRACLVSRRFYSPPAAGVKLDDNFSLETHTDIQAAAKAQASARASASGTTPDAVVASGSTAMSHAYQENTGFGTRPIYLDMQATTPTDPRVLDTMLKFYTGLYGNPHSNTHSYGWETNTAVENARAHVAKMINADPKEIIFTSGATESNNMVLKGVPRFYKKTKKHIITTRTEHKCVLEAARAMMKEGFEVTFLNVDDQGLIDLKELEDAIRPDTCLVSVMAVNNEIGVIQPIKEIGAICRKNKIYFHTDAAQAYGKIHIDVNEMNIDLLSISSHKIYGPKGIGAIYVRRRPRVRLEPLLSGGGQERGLRSGTLAPPLVAGFGEAARLMKKEFDNDQAHIKRLSDKLVKGLLSAEHTTLNGSPDHRYPGCVNVSFAYVEGESLLMALRDIALSSGSACTSASLEPSYVLHALGKDDALAHSSIRFGIGRFSTEEEVDYVVKAVSDRVKFLRELSPLWEMVQEGIDLNSIKWSGH
What is the function of this protein?
Catalyzes the removal of elemental sulfur from cysteine to produce alanine (PubMed:15220327).  It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters (PubMed:10406803, PubMed:10551871, PubMed:15220327, PubMed:31040179).  Plays a role in both tRNA-processing and mitochondrial metabolism (PubMed:15220327).  Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs (PubMed:14722066, PubMed:15220327, PubMed:8444805).
What are the official names of this protein?
Cysteine desulfurase, mitochondrial, tRNA-splicing protein SPL1.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HMBX1_MOUSE
Sequence: MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDKFGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPSNSYDTSPLPCTTNQNGRENNDRLSTSNGKMSPSRYHANSMGQRSYSFEASEEDLDVDDKVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKKRAFYRWYQLEKTNPGATLSMRPAPIPIEDPEWRQTPPPVSATPGTFRLRRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRRKEIKRRANIAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDDSTSHSDHQDPISLAVEMAAVNHTILALARQGANEIKTEALDDD
What is the function of this protein?
Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (By similarity).  Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (By similarity).  Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (PubMed:23685356).  Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (By similarity).  Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (By similarity).  Might also be involved in the DNA damage response at telomeres (By similarity).
What are the official names of this protein?
Homeobox-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome, telomere. Nucleus, Cajal body. Nucleus, PML body. Note=Predominantly detected in cytoplasm. Localizes in a dynamic manner to actively processed telomeres. Localizes to the periphery of Cajal bodies. Associates with PML nuclear bodies in telomerase-negative cells.
Protein: GATC_METCA
Sequence: MSLSAAEVNKIAWLARLAIDDDKVEAYARDLSQILGFVEQLGSVDTSRVAPMAHPLDEAQRLRPDDVTETDQRALFQAHAPLVEAGLYLVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: MUTL_ALIF1
Sequence: MPIQILPARLANQIAAGEVVERPASVVKELVENSIDAGATRIDIDIEKGGSKLIRIRDNGSGIPKDELTLALSRHATSKITSLDDLEAIVSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAYAEGREMNVKLKPAAHPIGTTIDVVDLFFNTPARRKFLRADKTEFTHIDELLKRIALSRLDVTINLRHNGKMVRQYRAAQTKPQIEKRLAAVCGANFLQHALEVELEHGELKFHGWISSPEGARAQGDIQYCYVNGRMMKDKLINHAIRQGYESSLPANQYAAYILFIEINPHDVDVNVHPAKHEVRFHQARLVHDFIYQAIFGALQQGASLPDVVGHIQSEAEEQQLESKESYFPPMKEYVRQPQQTHYPKSEQLRAAVESTPSYPNKAPLDSWIPKGNVGSSSSNSTAPSRSFHTDKPTKKALSNYNELLTTQNREQRESTSQVNEQSHTFRSTQQIERVAPQVTQVSKNGITLGKVLSVVESTFALLQQGKQLQLLNLRYAEFVKIYGQLSSVNVEPLKPQPLLIPLSVGIDESICNNLSNYASLLKSLGIDLKVKNRTNIIVMAVCQPIRQQNLQQLIPNLLRYLEQINPSLEQVIKWLSHQIQHDEVSYTTAQAIQLVMELEQLWGDELNNFYPKLLKDIDITQVIQAFSHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: UNG_ALKCK
Sequence: MPILRNDWNDVIGGEFQKTYYLELREFLKREYKEQTVYPHMNDLFNAFHYTPFEQVKVVILGQDPYHGPNQAHGLSFSVKPEVAVPPSLKNMYKELQDDLGVTPVDHGYLQPWADQGVLLLNTVLSVRKRQPGSHKGKGWELFTNEVIHALNKREEPVAFVLWGRHAQAKKEAIDATRHLIIESAHPSPFSANRGFFGSRPFSKINHWLQEQGKAPVDWQLPMKAELYSYGK
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODPX_MESAU
Sequence: FRLSPAARNILEKHSLDASQGTATGPR
What is the function of this protein?
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes.  This specific binding is essential for a functional PDH complex (By similarity).
What are the official names of this protein?
Pyruvate dehydrogenase protein X component, mitochondrial, Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, Lipoyl-containing pyruvate dehydrogenase complex component X.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CLPB_LEPIN
Sequence: MKLDKLTSKLNEAIYNAQASAEKLGNPEISEEHILKEVLSQPDGLVPLLISKLNLSPKSFLESTENALGKQPKVGGNTSADVGFSRSAVSLLKAADEVRKELKDEYLSTDHILLGLMKNGTGSLKTEFLKLGLEYHKLLKITLENRKGKTIMDDSPEGKTDALAKYAKNLNELAKQGKLDPVIGRDEEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLANKIVQGEVPEGIKNKTLYTLDLGSMIAGAKYRGEFEDRLKALLDEVKSSDGEVILFIDEIHTLVGAGATEGALDASNMLKPMLARGELRCIGATTLKEYQKYIEKDAALERRFQPVYVKEPSVEETVTILRGLKGRYELHHGIRILDSALIAAATLSNRYISDRFLPDKAVDLIDEASSKMRIEIDSMPEELDRANKRIQSLKIEREALKKEQDTASKERLKTLERDLSEQEQNFQTLKARWDLEKSKIGRLKQIKEEIEKYKNLEAEAERRGEINRVAEIRYGKLVDLQKELESANEELKKQESASRLLKEEVSEEDIANIVSRWTGIPVSKMLQGERAKLLLMEDVLKTKVIGQDHALRLVSEAVQRSRAGIADPNRPIGTFLFLGPTGVGKTETAKALAEFLFDDVNAMTRIDMSEYMEAHSVARLIGAPPGYVGYDEGGQLTEAVRRRPYSLILFDEIEKANPEVFNIFLQILDEGRLTDGKGRNVDFKNTVIILTSNIGSEVLGSSEYTSEEKERLVEQRLKKHFKPEFLNRIDEVILFHSITDSVIHKIADIQLEGLRQKAKENGLDVSFTNELKDYVSKAGFDAEYGARPLKRLIQREVGNALSRYILDGKFTNGQNVTVDYRQGKVVVVV
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.