Protein: CM3B_CORMM
Sequence: MQSDTNNSPLSWEELRSGAASSDANSSPPEPIAIIGMSCRLSGSAQDPSSLWEMLTSGRTAWTPGPGQRFNMEAFQSSSADTFGMTNTGGGHFLKEDVAAFDAAFFGIHAVEAKAIDPQHRLLLEIAYECFDNSGLNMDSLWGSNTGVYVGQWANDYHEIQTRDIDAPPLYLTTGTGPAISSNRISYFFNLRGPSFTVDTGCSSGFVALHQAVQSLRSGETSQCFVGGVNLMLDPQRFVYQSKLKMFSNEGRSFAFDSRANGYGRGEGCTAVMLKPLSAALRDGDQIRAVIRNSVLNQDGRTAGITVPSPEAQEEAILKAYGDAMLELRADYVEAHGTGTKVGDPKEAGAIAAALARGNSPGAALPIGSIKANIGHTESAAGLAGLIKAVLMLEHGIIPPQANYESPNPDLCLEERGLRVPTQLERRTLRRISVNSFGYGGTNAHVVVDASADALCALSSLGRHTSAQRVFFISGASEKACQRICARLAKYLARKSAWPETDTPELLAKLAYTLSKKSIHPYRLALVAQDINELVQQLISAAYSPVARQDRKGDTRIGLVFSGQGSQYAEMGRELLSSSAVFSRSIDRACQHLTELGSGWNMREELCRPQETTRINEPALSQPLTTAIQLALVDLLFDLKISVSAVVGHSSGEIAAAYAAEAISFEDAMTASYYRGSLTSSLVVGNPECDGAMLAVGADADVVNQRISEVGDAHGRMRIACFNSPSSVTVSGDAKAVNELRKLLVAEGTFNRMLPTNGAAYHSHQMESMNKEYTLSLQKKLSPKKKTSISAARIFSSVTGKENDLQTPLDGVYWAANLLSPVLFSQALREMCEAKYDGKALDMIIEVGPHSQLGGAVKQTVKALKSSSGIAYTSVLKKGKKARQAFLECLGALHVCTATVDLNASNGFSATHAPKLLVDLPPYPFDHERSFWHETRISKDYRHRKHAPHELLGTFAHDTNRVEPRWRQFLSLKQTPWLKSHAVQGQIVFPGAGFLTMAIQAMLQHMHATSPLVKVHSLLLRNVSLSRALVLPADGPDVEITLTLRPESHTAKSSSAVWSEFRIFTVTSESVWTEHCRGLVHAETQAADVDEIAADVKDTLEAGETCVHEVTPQKLYHLGSEIGLDWQHPFNNVSNIRTSRDACVAVARKTVLDSDVGGMGDILHPTVLDSCLFHGLSAVLVLERGSTSTFVPNFIEQLQIFNRTPDSSAELLSTSKLSRDTSTCDVVVQEKGCSPGQAVIFAAKGVHTTTLPGDTGLNEVIDDICHSQDWVTYVDAWTPEHCDRFVQKAVKEVDPERVPDGPRRQFFEWMKIYAETPLDEQTLPPASISADHWAFYEGVKRLGPHLADILVEKTDPLALLTPDNLLGQLYNTERCRRCIVQMAEYCHALGQQSPGLKVLEVGAGTASATLPAIEALNGRGSINAHSYTFTDLSPAFFDPAKERLGSFADAVKFDILDIERCPLEQGFQEAGYDLIIASNVIHATQRIDAVLANIKKLLKPGGKFMLMELTVPTPHYNLLFGVFKGWWAGYDEGRQLSPLIPPSEWVTRLTRAKFSPAELWFQDYPEENGGTISVLIASAPWDVAQVELPAIDVVTTEYSALESGDEAVLRTLSSSEELLNTNISVGCLSDISSKDNIVIILPEVARYLCQSLHGSAWERFKHLVLNARAVLLVGCSSSYCSDFVSGGIWLGFARCLRLELPRLRVITLDLAVERALMMKRLTSVLPTLMRSIKQGLALDGRVEVENEFRESDGQLYVSRLVSNDKMSEYVHRSRQRAQPKLLSFMDPQRPMTAELRVPGLLESIRWKDDVKATAVGPDEVKLELRAASINFKDVLIAAGQLEGINEMRNDCSGVVIEVGSNMCDRFKAGDRVCALYSRSYTNYPVVHGDCCQVVPDSMTYEEATALPVVWTTVYYSLVDAGRLEQGDKILIHSAAGAVGQAAIMLAKHIGAEVFATVGNSEKQTLLRERYGIADDHIFSSRTPAFHDKIKRLTGGYGVDVVLNSLAGDQFRHSCNLVAPFGRFVEIGRKDLMDDARMSMGFLLKNVTFAYVDLSLIMEVKRPLARRLLREVVNLAASGAIRPVTLTTLPITEIETAFRMIQAGKHTGKIVLRVAQDQIVKADPPAPAHAELKPNATYLLVGGFGGLGRAVITWMGSRGAKNILVISRSGSPDKQGQILIKDMEAMGVKVVAEKCDVTAEDEVASLSKLAADRGLPPIRGVIHSAMVLQDSVLEEMTADEWCRALAPKYAGSLNLHRSFGNEVDFFIFMSSAVALRGNVGQSNYAAACSFQDALARYRTAAGLPAFSINVGPVREVGFVSENPQVAAALRKQGLGTISMADLLTLLNYAVVHRNPEESVCSIGMLPRDTDESLTDRRFAHLVRHDVVSQTADAGGVQFADIPRLLDGAAPGAQLLENISQLVLMQLSKLIASPVETLSAAQSLDSYGVDSLVAVELRNWVGAYLQANVPLMVLRGTSSIHELAKIIAKESRRPSTLLWRSTLLYSYPDLDKLQHDMPAQISWPANS
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of beauveriolides I and III, cyclodepsipeptides acting as inhibitors of the acyl-CoA:cholesterol acyltransferase (PubMed:31926180).  The HR-PKS cm3B initiates the biosynthesis of beauveriolides by iteratively catalyzing the formation of the linear polyketide chain (Probable).  The ATP-dependent acetyl-CoA ligase cm3D converts the polyketide carboxylic acid to a CoA thioester which id shuttled to the first T domain in the NRPS cm3A by the acetyltransferase cm3C (Probable).  Cm3A contains 13 domains and assembles the polyketide chain, L-phenylalanine, L-alanine, and D-leucine (or D-allo-isoleucine) to form beauveriolide I (or beauveriolide III).  The production of both beauveriolides I and III suggests the substrate adaptability of cm3B, using different amino acids as substrates (Probable).
What are the official names of this protein?
Highly reducing polyketide synthase cm3B, HR-PKS cm3B, Beauveriolides biosynthesis cluster protein B, Cyclodepsipeptides cm3 biosynthesis cluster protein B.