PharMolix/UniProtQA huggingface dataset:
Protein: AROK_BRUSU
Sequence: MSGTNKQTNLHRQTETIRQLLGSKVVVLVGLMGAGKSTIGRKVANMLNLPFKDADTEIETVSRMTVAELFEAYGEVEFRDLERRVILRLLDDGPMVLATGGGAYMNAETRAAIAEAGISIWINADLDVLMERVSRRQNRPLLRNSDPRGVMQRLMDERYPVYALAELHLMTRDEKKEVIAAELIEVLAAHLEKEQAASAG
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_NEIG1
Sequence: MLQTDNLTAAQPQRIVAAQTASAQEELLERALRPKTLDDYIGQHKAKEQLAIFIQAAKKRGEALDHVLLFGPPGLGKTTLAHIIAKELGVNLRQTSGPVLERAGDLAALLTNLDPHDVLFIDEIHRLSPVVEEILYPALEDYRLDIMIGEGPAARSVKIDLPPFTLVGATTRAGMLTNPLRDRFGIVSRLEFYENRDLTTIVSRSAQLLQLDMGEEGAMEVAKRSRGTPRIANRLLRRVRDFADVKNNGVIDAAVADAALSMLDVDAQGLDVMDRKFLEAVLHKFGGGPVGLDNVAAAIGESTDTIEDVIEPYLIQQGFLQRTPRGRMATERAYLHFGLPVEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL16_COXBU
Sequence: MLQPSNRKYRKDFKGRNRGVASRGNRVSFGEFGLKATECARITARQLEAARRTIARHIKRGGKITIRIFPDKPITKKPLEVRQGKGKGSVEYWVALVQPGRMIFEIEGVDEALAREAFSRAAAKLPLKCLFVKRTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RS7_PETMO
Sequence: MRRRTAEKRNIVPDPIYGDILLSKFINRLMYDGKKSLAQQIVYSALERLAEATKENPIEAFHKAIDNVKPVVEVRSRRVGGSTYQVPFEVPENRATSLAIRWIVTSAQSKKGRDMVSKLSQELIDAYNNTGPSVKKKEDVHRMAEANRAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ACT8_ARATH
Sequence: MADADDIQPIVCDNGTGMVKAGFAGDDAPRAVFPSVVGRPRHHGVMVGMNQKDAYVGDEAQSKRGILTLKYPIEHGVVSNWDDMEKIWHHTFYNELRIAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGFSLPHAILRLDLAGRDLTDYLMKILTERGYMFTTTAEREIVRDIKEKLSFVAVDYEQEMETSKTSSSIEKNYELPDGQVITIGAERFRCPEVLFQPSFVGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFSGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWISKAEYDEAGPGIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.  This is considered as one of the vegetative actins.
What are the official names of this protein?
Actin-8.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: T2R50_PANPA
Sequence: MITFLYIFFSILIMVLFVLGNFANGFIALVNFIDWVKRKKISSADQILTALAVSRIGLLWTLLLNWYLTVLNPAFYSVELRITSYNAWVVTNHFSMWLAASLSIFYLLKIANFSNLIFLHLKRRVRSVILVILLGTLIFLVCHLLVANMDESMWAEEYEGNITGKMKLRNTVHLSYLTVTTLWSFIPFTLSLISFLMLICSLCKHLKKMQLHGEGSQDLSTKVHIKALQTLISFLLLCAIFFLFLIISVWSPRRLRNDPVVMVSKAVGNIYLAFDSFILIWRTKKLKHTFLLILCQIRC
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 50, T2R50.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: COX2_DANRE
Sequence: MAHPAQLGFQDAASPVMEELLCFHDHALMIVFLISTLVLYIIIAMVSTKLTNKFILDSQEIEIVWTVLPAIILILIALPSLRILYLMDEINDPHVTIKAVGHQWYWSYEYTDYENLEFDSYMVPTQDLTPGGFRLLETDHRMVVPKESPIRILVSAEDVLHSWAVPSLGIKMDAVPGRLNQTAFIVSRPGVFYGQCSEICGANHSFMPIVVEAVPLEFFENWSSAMLEDA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HEM1_ECO45
Sequence: MTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLARQIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERLREADIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQEASEFMAWLRAQSASETIRDYRSQAEQVRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDSLGLE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: VP54_LYCMC
Sequence: MNFQVFSLIFFNFVYYCSCSTFEEALCELEKEERVKVLRCYEENTDPGILLYSKSFLSCLLDERASFITLNEMACGKTFSTNERRACFEEANVFLVNFTEEMKKKHKNAVKKCFDK
What are the official names of this protein?
Venom protein 54.1.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_CAMLR
Sequence: MASYGMGDLKKGLKIEIDGIPFKIVEYQHVKPGKGPAFVRIKIKSFIDGKVLEKTFHAGDKCESPNLEEKQMQYLYDDGENCQFMDTQTYEQVAISDEDVGEAKKWMLDGTMVDVLFHNGKAIGVEVPQVMELKIIETAPNFKGDTQGSNKKPATLETGAVVQIPFHVLEGEIIRVDTVRGEYIERANK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PES10_CAEEL
Sequence: MNKNEYMMHLLARTIRTRNDDMITPLITQLADMQVSMDILEKHNFPALVAEYAPFNKAAQSLSHSVLVWKNDELAQEKSYMLKEFVRICKDQHQPEEFLLRLTCSLINLNDFELTRSCFDIIVSFGLTLNAYDEFGIFRKAMEYQGQMEEADKIISDVDAMLLRNEFLEEDEAEEQADNEMDAFEEEGVEEVDQEVVDFNDNESVISETESGVFTDEELDMEDHAEVMRRHAQDQALVSEICMVFLAGCIKSGRSDVISAAIQFTGAFFYPLALLRKYDIQYLIYCYGSHNEDAELLMNHIKHLQAIEIAGERQEFFKMFMETTFRNAETVTDSVMAQMKGFLEDGDDFMISCTLHVFLKMPITLSQFKNSHVEACLENLESGLAAQLGFMLKMKIQLLEQIDYEIW
What are the official names of this protein?
Patterned expression site protein 10.
What is the protein family that this protein belongs to?
Belongs to the Pes-10 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL41_ORYSJ
Sequence: MRAKWKKKRMRRLKRKRRKMRQRSK
What are the official names of this protein?
60S ribosomal protein L41.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL41 family.
Protein: NOC_BACC4
Sequence: MKNTFSRLFGFGDKESEFELQDESHEEIDKKVYEEIQEIPIVNITPNRYQPRTVFDDARIDELALTIRTHGLIQPIVVRQYEDDKYEIIAGERRFRAATKLGWEKVPAIIKNLNDTETASVALIENLQREELTAIEEAVAYQKLIELHNLTQEALAQRLGKGQSTIANKLRLLKLPEEIKSALLEKSITERHARALIPLKNEELQLKVLQEIVEKQLNVKQTEERIAKLLEEAKPKRKAKQKAVSRDTRIAMNTIRQSLQMVTESGLNVNSEEEEFDEYYQITIKIPKKK
What is the function of this protein?
Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle.  It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.
What are the official names of this protein?
Nucleoid occlusion protein, Noc.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RS16_BEII9
Sequence: MSLKIRLARGGAKKRPFYRIVVADARAPRDGRFIERIGTFDPLKAKNAPDRIVLDAEKAKDWLAKGAQPTDRVARLLDGLEIIKRESRNNPQQGQPKKKAQERAAAAAAAAEKAASEAAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: MSRQ_SHISS
Sequence: MRLTAKQVTWLKVSLHLAGLLPFLWLVWAINHGGLGADPVKDIQHFTGRTALKFLLATLLITPLARYAKQPLLIRTRRLLGLWCFAWATLHLTSYALLELGVNNLALLGKELITRPYLTLGIISWVILLALAFTSTQAMQRKLGKHWQQLHNFVYLVAILAPIHYLWSVKIISPQPLIYAGLAVLLLALRYKKLRSLFKRLRKQVHNKLSV
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD_ENT38
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKKAKDIMDAGKLVTDELVIALVKERITQEDCRNGFLLDGFPRTIPQADAMKEAGINVDYVLEFAVPDELIVDRIIGRRVHAASGRVYHIKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYHQMTAPLIGYYSKEAQAGNTQYAKVDGTKPVAEVRAELEKILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLYL_PAEPS
Sequence: MFKRNDRSKNGFNALRLGVSFVLASSCLIGTAYADVPSNNLPSTTLTEEAVSATDSAAASTTLAAGDLYVAPNGNVSNPGTISSPTTLEAALTQIAPGKTIYLRGGNYAYSSTITIQRGNNGSNGSLKGLVAYGSEKPVLDFSAQAFGSANRGLQLNGDFWLVKGLEVKGAGDNGIYIGGSNNRIENVETHHNRDTGLQLGRYSPNASTSEWPANNLILNSYSHDNADPDNGEDADGFAAKLTVGSGNVFDNCLAAYNVDDGWDLYSKTETGPIGAVTILNSVAHHNGQTSDGTSTANSDGNGFKLGGDKIKVNHIVKNSIAFQNKKHGFTYNSNPGTITLTNNTSWDNGQSNFAFDKGEHVFINNLSFEGTASDKTSGTDQDNSNVWWKNKKTTNAKGLAASADDFVSLVPSITRGADGSIQLGDFLKLAKGSDLIGSGTPSGNIGAR
What is the function of this protein?
Presents an endo-cleaving activity on the homogalacturonan (HG) region in pectin with a preference for low- or unmethylated pectin.
What are the official names of this protein?
Pectate lyase L, PpPel9a.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 9 family.
Protein: ANXA2_CANLF
Sequence: MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
What is the function of this protein?
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids.  It binds two calcium ions with high affinity.  May be involved in heat-stress response.  Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
What are the official names of this protein?
Annexin A2, Annexin-2.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=In the lamina beneath the plasma membrane.
Protein: RS3_FRACC
Sequence: MGQKVNPHGFRLGITSEFTSRWYADKQYKAYVGEDVKIRKMMSRGMERAGISRVDIERTQGRLRVDIHTARPGIVIGRRGAEADRIRGDLEKLTGKQVQLNILEVKNPEVDAQLVAQGVAEQLSSRVSFRRAMRKAMQTAMKGGAKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGFYEARTNFGRIGVKVWIYKGDIVQSRAEREAQEALQRQTRRERPRRGPRSGSSGTTQGGTEAGRAAARGERRGRGGGGGNAPAETPAGEAAATEPTAPVAEPATAAASAPAEAASAPAEAAVANTPEKAEE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: HPRK_CHLPD
Sequence: MTLEQKGLKKQSITVAYFFDTIGKEHDIKLRRLNSVDEQKRRIFERDLHRPGLALAGFTNLFTYKRVQILGNTEMRFLNQHEEDARKNAFGNFVRFKIPCIILTSTNKLQPELLAMATEAGIPVFSTRHSSTKTMYLITEFLDNQFSLYQQYHGSMVDVYGVGVLLKGRSGLGKSEVALDLVERGHGLVADDVVVIHRKGESMILTAKRNKNIEHFMEIRGLGVVDVKANFGIRAIRDAKEVQVVVELLEWNKEMEYERLGLDTKTTKILGVEVPLVQLPIFPGKNITVIIEVVALNFLLKHYYDYVPAEALTKRIRTAIDQ
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: TRCM_PYRAB
Sequence: MDYKEEFKKINKKLVERYSKLDDSEEFWAYLYKPLRPSIRINTLKGNLKEIKALLEEKFELEPIPWTKGEGFYIKSYDVNYGQLIEYSLGLIIPQEASSMIPPVVLDPKPSEVILDMAAAPGSKTTQMAQYMENEGCIIANDAKRDRANILIANLTRAGVLIAKVTVKDGAYFARYENTFDRVLLDAPCSSVGMIRKNFKFARTWSIGKVYYHSRLQKRLILAAYKSLKPGGVLVYSTCTVDPLENEEVVDFLLQKTDAKLEKVKLPLKTSEPVIEWEGRKYSDEVRKTIRIHPQDNDTEAFYIAKIRKPR
What is the function of this protein?
Catalyzes AdoMet-dependent formation of m5C in tRNA.  In the presence of protein archease, specifically methylates the cytosine at position 49 (m5C49) of tRNA.  In the absence of archease, catalyzes the formation of m5C at many locations in tRNAs or rRNAs.
What are the official names of this protein?
tRNA (cytosine(49)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EREG_HUMAN
Sequence: MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
What is the function of this protein?
Ligand of the EGF receptor/EGFR and ERBB4.  Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975).  Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).
What are the official names of this protein?
Proepiregulin.
What are the subcellular locations of this protein?
[Epiregulin]: Secreted, extracellular space. SUBCELLULAR LOCATION: [Proepiregulin]: Cell membrane; Single-pass type I membrane protein.
Protein: TAM_ECO5E
Sequence: MSDWNPSLYLHFAAERSRPAVELLARVPLENVDYVADLGCGPGNSTALLHQRWPAARITGIDSSPAMIAEARSALPDCQFVEADIRNWQPEQALDLIFANASLQWLPDHYELFPHLVSLLNPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGRESLAGVHAYYDILSEAGCEVDIWRTTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLTRYHQMLKEQYPLQENGQILLAFPRLFIVARRTE
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLDC3_RAT
Sequence: MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVRPAVRGQAPVVPYMRYGHSTVLIDDTVFLWGGRNDTEGACNVLYAFDVNTHKWSTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQLADCFSNDIHKLDTSTMTWTLVCTKGNPARWRDFHSATMLGNHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPHTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPGSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELNAMTTNSNISRPIVSSHG
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.  The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons.  The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine.  May be involved in meiotic recombination process.
What are the official names of this protein?
Kelch domain-containing protein 3.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXA_VIBC1
Sequence: MIHETAKIHPAAVVEEGAKIGANVTVGPFTYITSTVEIGEGTEVMSHVVIKGHTKIGKDNRIFPHAVIGEENQDKKYGGEDTTVVIGDRNVIREAVQVHRGTVQDKATTVIGDDNLLCVNAHIAHDVVVGNHTHIGNNAILGGHVTVDDHAGVMALSAIHPFCTVGAYAYVGGCSAVVQDVPAYVLAQGNHATPFGLNLVGLKRNGFEKPEIRALQKAYKEIYRSGKTLEEVKPILAEMAQEWPAVKRFSDILETTERGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIA7C_MOUSE
Sequence: MACILKRKPVLVVSFIALCILLLAMRLVNDATFPLLLNCFGQPKTKWIPLPYTFRQPLRTHYGYINVRTQEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWGPFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYGMINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNWTLS
What is the function of this protein?
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage.  Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains.  ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:10207017, PubMed:10601645).  GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity).  Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (By similarity).
What are the official names of this protein?
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, GalNAc alpha-2,6-sialyltransferase III, ST6GalNAc III, ST6GalNAcIII, STY, Sialyltransferase 7C, SIAT7-C.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.