PharMolix/UniProtQA huggingface dataset:
Protein: PYVF_ASPV1
Sequence: MAGSPFTTALLSAWTLSTVAVGYPNGPWYQTPLGPDVVRDPTRYPGAIEKTVDYVVVGGGASGLTVAARLSEDPSVTVAIVEAGSFYQEVSNASVVPGYAADYLTGHIPPELDWGFNTEPQAGADGRVKHYTNAKTLGGNSAFNLMAYMTTSVGAMQKWAEEVDDDSWTYANVTRYFQKSLNFTGIDPHKRRANSTPELNPADVGYGGPLDVTYPNYAQPFSSWVKKAFDQVGMRPVGGFMSGELFGSSWVLDTINHTDGQRASSAKTFLEPILHRRENLFLYNRTLAERVLFDADRTATGVQASRGKTVFNLTATKEVVLTAGGLMTPQLLQVSGVGNAALLQELRIPVVLDAPQVGQQMEDHISFGVAHRVDVETNSALKYAGPRQHAVEEFNEAQAGILSSPGPDFGGFADIPSELRNFSASTHADLAGLPKDWPEGFFISFPVDVGFPQDGYNYAMIVCTLMTPMSRGHISIRSPSMHDRPVIDPRWLTSTSDVEIAVAAVRRIRQYLQMPVLERNVLVGGEVAPGPEVQTFAEIHDYLKKNFNSMSHPACTCRMGKKGDPDAVVDPKGRVFGVKNLRIADASVFRFLPPGLPLGVVYMVAEKIADDIKHDQKHGAGEEGLRTEF
What is the function of this protein?
Dehydrogenase; part of the gene cluster that mediates the biosynthesis of pyranoviolin A, a pyranonigrin analog with a C-3 methoxy group (PubMed:33117309).  Initially, the PKS portion of pyvA synthesizes C-10 carbon chain from 5 molecules of malonyl-CoA, which is then condensed with the thiolation (T) domain-bound glycine activated by the adenylation (A) domain (PubMed:33117309).  The subsequent chain release by Dieckmann condensation (DKC) could be catalyzed by the TE domain present at the C-terminus of pyvA and/or the alpha/beta hydrolase pyvD, installing the tetramic acid moiety (Probable).  The FAD-dependent monooxygenase pyvC next epoxidizes one of the olefins of the polyketide part, and the epoxide ring-opening induces the dihydro-gamma-pyrone ring formation (Probable).  The cytochrome P450 monooxygeanse pyvB would be responsible for the 2 consecutive reactions, in which the dihydro-gamma-pyrone is oxidized to gamma-pyrone and C-7 is hydroxylated to yield pyranonigrin F (Probable).  Finally, the O-methyltransferase pyvH methylates the C-3 hydroxy group to complete the biosynthesis (Probable).
What are the official names of this protein?
Dehydrogenase pyvF, Pyranoviolin A biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: ISPE_PSEAB
Sequence: MSVRLSLPAPAKLNLFLHILGRRDDGYHELQTLFQFLDHGDELHFEARQDGQVRLHTEIAGVPHDSNLIVRAARGLQEASGSLQGVDIWLDKRLPMGGGIGGGSSDAATTLLALNHLWQLGWDEDRIAALGLRLGADVPVFTRGRAAFAEGVGEKLTPVDIPELWYLVLVPQVLVSTAEIFSDPLLTRDSPAIKVRTVLEGDSRNDCQPVVERRYPEVRNALILLNKFVSARLTGTGGCVFGSFPNKAEADKVSALLPDHLQRFVAKGSNVSMLHRKLETLV
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: COBK_RHOCB
Sequence: MTRLLVLGGTTEASRLAKTLADQGFEAVFSYAGRTGAPVAQPLPTRIGGFGGVAGLVDYLTREGVSHVIDATHPFAAQMSANAVAACAQTGVALCAFERAPWTAQAGDRWTHVPDLAAAVAALPQAPARVFLAIGKQHLRDFSAAPQHHYLLRLVDPPEGPLPLPDARAVIARGPFTVQGDTELLRSETITHVVAKNAGGAGAEAKLIAARSLGLPVILIDRPAVPARDICATLEGVMGWLADHGATPRGV
What is the function of this protein?
Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
What are the official names of this protein?
Precorrin-6A reductase, Precorrin-6X reductase.
What is the protein family that this protein belongs to?
Belongs to the precorrin-6x reductase family.
Protein: DLDH_HALSA
Sequence: MVVGDISTGTDVAVVGAGPGGYVAAIRAGQLGLDVTLVEKDAYGGTCLNYGCIPSKAMITASGVAHEAGHAEEMGVYADPDVDVAEMVDWKDGVVDQLTGGVEKLCKANGVNLIEGRAEFAGSDKLRVVHGGDGQGSETIEYEHAIVSTGSRPIEVPGFDFGDDPVLDSRQALAMAELPSSMVIVGGGYIGMELSTVFAKLGVDVTVVEMLDGILPQYGDDIARPVRQRAEELGIDFHFGLAADSWTDTDDGIVVTAADEDGEETEFETEKVLVAVGRQPVTDTLNLDAVGLEPNDDGRLETDHEARTDVENVFAIGDVAPGPMLAHKASKEGEVAAEVIAGEPAALDYQAVPAAVFTDPEIGTVGLTEDDAAAQGFDPVVGTFPFNASGRALTTGHDDGFVEVVADEESGFLLGAQIVGPEASELVAELGLAIEMGATLEDVASTIHTHPTLSEATMEAAEHALGHAVHTLNR
What are the official names of this protein?
Dihydrolipoyl dehydrogenase, Dihydrolipoamide dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFA65_HUMAN
Sequence: MFTLTGCRLVEKTQKVENPSVSFASSFPLIPLLLRGKSVQKKQAESKSQIKLHTQSAPFGLCPKDMMLTQAPSSVVRSRNSRNHTVNSGGSCLSASTVAIPAINDSSAAMSACSTISAQPASSMDTQMHSPKKQERVNKRVIWGIEVAEELHWKGWELGKETTRNLVLKNRSLKLQKMKYRPPKTKFFFTVIPQPIFLSPGITLTLPIVFRPLEAKEYMDQLWFEKAEGMFCVGLRATLPCHRLICRPPSLQLPMCAVGDTTEAFFCLDNVGDLPTFFTWEFSSPFQMLPATGLLEPGQASQIKVTFQPLTAVIYEVQATCWYGAGSRQRSSIQLQAVAKCAQLLVSIKHKCPEDQDAEGFQKLLYFGSVAVGCTSERQIRLHNPSAVNAPFRIEISPDELAEDQAFSCPTAHGIVLPGEKKCVSVFFHPKTLDTRTVDYCSIMPSGCASKTLLKVVGFCRGPAVSLQHYCVNFSWVNLGERSEQPLWIENQSDCTAHFQFAIDCLESVFTIRPAFGTLVGKARMTLHCAFQPTHPIICFRRVACLIHHQDPLFLDLMGTCHSDSTKPAILKPQHLTWYRTHLARGLTLYPPDILDAMLKEKKLAQDQNGALMIPIQDLEDMPAPQYPYIPPMTEFFFDGTSDITIFPPPISVEPVEVDFGACPGPEAPNPVPLCLMNHTKGKIMVVWTRRSDCPFWVTPESCDVPPLKSMAMRLHFQPPHPNCLYTVELEAFAIYKVLQSYSNIEEDCTMCPSWCLTVRARGHSYFAGFEHHIPQYSLDVPKLFPAVSSGEPTYRSLLLVNKDCKLLTFSLAPQRGSDVILRPTSGLVAPGAHQIILICTYPEGSSWKQHTFYLQCNASPQYLKEVSMYSREEPLQLKLDTHKSLYFKPTWVGCSSTSPFTFRNPSRLPLQFEWRVSEQHRKLLAVQPSRGLIQPNERLTLTWTFSPLEETKYLFQVGMWVWEAGLSPNANPAATTHYMLRLVGVGLTSSLSAKEKELAFGNVLVNSKQSRFLVLLNDGNCTLYYRLYLEQGSPEAVDNHPLALQLDRTEGSMPPRSQDTICLTACPKQRSQYSWTITYSLLSHRDNKAGEKQELCCVSLVAVYPLLSILDVSSMGSAEGITRKHLWRLFSLDLLNSYLERDPTPCELTYKVPTRHSMSQIPPVLTPLRLDFNFGAAPFKAPPSVVFLALKNSGVVSLDWAFLLPSDQRIDVELWAEQAELNSTELHQMRVQDNCLFSISPKAGSLSPGQEQMVELKYSHLFIGTDHLPVLFKVSHGREILLNFIGVTVKPEQKYVHFTSTTHQFIPIPIGDTLPPRQIYELYNGGSVPVTYEVQTDVLSQVQEKNFDHPIFCCLNPKGEIQPGSTARVLWIFSPIEAKTYTVDVPIHILGWNSALIHFQGVGYNPHMMGDTAPFHNISSWDNSSIHSRLVVPGQNVFLSQSHISLGNIPVQSKCSRLLFLNNISKNEEIAFSWQPSPLDFGEVSVSPMIGVVAPEETVPFVVTLRASVHASFYSADLVCKLYSQQLMRQYHKELQEWKDEKVRQEVEFTITDMKVKKRTCCTACEPARKYKTLPPIKNQQSVSRPASWKLQTPKEEVSWPCPQPPSPGMLCLGLTARAHATDYFLANFFSEFPCHFLHRELPKRKAPREESETSEEKSPNKWGPVSKQKKQLLVDILTTIIRGLLEDKNFHEAVDQSLVEQVPYFRQFWNEQSTKFMDQKNSLYLMPILPVPSSSWEDGKGKQPKEDRPEHYPGLGKKEEGEEEKGEEEEEELEEEEEEEEETEEEELGKEEIEEKEEERDEKEEKVSWAGIGPTPQPESQESMQWQWQQQLNVMVKEEQEQDEKEAIRRLPAFANLQEALLENMIQNILVEASRGEVVLTSRPRVIALPPFCVPRSLTPDTLLPTQQAEVLHPVVPLPTDLP
What is the function of this protein?
Plays a role in flagellar formation and sperm motility.
What are the official names of this protein?
Cilia- and flagella-associated protein 65, Coiled-coil domain-containing protein 108.
What is the protein family that this protein belongs to?
Belongs to the CFAP65 family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed in flagella midpiece and acrosome of mature spermatozoa.
Protein: EFG1_BORBR
Sequence: MARKTPIERYRNIGISAHIDAGKTTTTERILFYTGVNHKLGETHDGSATMDWMEQEQERGITITSAATTAFWRGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYGVPRLAFVNKMDRTGANFFKVYDQLKTRLRANPVPIVIPIGAEDSFTGVVDLVKMKAIIWDEASQGTKFEYGDIPAELEGTANEWREKLVEAAAESSEELMNKYLETGSLDEDDINVALRQRTIAGEIQPMLCGTAFKNKGVQRMLDAVIDYLPSPADIPPVDGQDDDGNPIKRSADDAEKFSALAFKLMSDPFVGQLTFVRVYSGVLKSGDTVYNPIKGKKERIGRLLQMHANNREEIKEVLAGDIAAVVGLKDVTTGETLCDIDSHILLERMEFPEPVISQAVEPKSKADQEKMGLALSRLAQEDPSFRVRSDEESGQTIISGMGELHLEILVDRMRREFGVEANVGKPQVAYRETIRKNCDEVEGKFVKQSGGRGQYGHVVLKLEPLPPGGGYEFVDAIKGGVVPREYIPAVDKGIQETLPAGILAGYPVVDVKATLFFGSYHDVDSNENAFKMAASMAFKEGMRRASPVLLEPMMAVEVETPEDYAGTVMGDLSSRRGMVQGMDDIVGGGKTIKAEVPLAEMFGYATNLRSLTQGRATYTMEFKHYAEAPKNVADEVIAARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 1, EF-G 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_SERP5
Sequence: MTSEIHCDSLWYGADIVTMRDGKYHTLSNGAIATRDGKIVWLGEYDALPATLTADERVKFDGGIITPGFIDCHTHLVFGGNRSAEFEQRLNGVSYAEIAAQGGGIISTVKATRDADEERLLEQALFRLRPLLAEGVTCVEIKSGYGLTPESEMKMLRVARRLGELLPVEVKTTCLAAHALPPEYANRADDYIDLVCNTIIPQAAAAGLADAVDAFCEHLAFSPAQVARVFAAAEAAGLPVKLHAEQLSALGGSELAAQHHALSADHLEYATEQDARAMGDAGTVAVLLPGAYYLLRETQCPPVDLFRKHNVAMAIASDANPGTSPALSLRLMINMACTLFRLTPEEALAGVTTHAAKALGLQASHGTLETGKVADFIHWPLSRPAELAYWLGGQLPCTVIFRGEIRQ
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCPA_STAAW
Sequence: MTVTIYDVAREARVSMATVSRVVNGNQNVKAETKNKVNEVIKRLNYRPNAVARGLASKKTTTVGVIIPDISNIYYSQLARGLEDIATMYKYHSIISNSDNDPEKEKEIFNNLLSKQVDGIIFLGGTITEEMKELINQSSVPVVVSGTNGKDAHIASVNIDFTEAAKEITGELIEKGAKSFALVGGEHSKKAQEDVLEGLTEVLNKNGLQLGDTLNCSGAESYKEGVKAFAKMKGNLPDAILCISDEEAIGIMHSAMDAGIKVPEELQIISFNNTRLVEMVRPQLSSVIQPLYDIGAVGMRLLTKYMNDEKIEEPNVVLPHRIEYRGTTK
What is the function of this protein?
Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.
What are the official names of this protein?
Catabolite control protein A.
Protein: KTNB1_MOUSE
Sequence: MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVTQDPVQANQPLTQQTPNPGVSLRRIYERPSTTCSKPQRVKHNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATVKEVSKPSPAMDVQLPQLPVPNLEVPARPSVMTSTPAPKGEPDIIPATRNEPIGLKASDFLPAVKVPQQAELVDEDAMSQIRKGHDTMFVVLTSRHKNLDTVRAVWTTGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDILAAPPSVGVDISREERLHKCRLCFKQLKSISGLVKSKSGLSGRHGSAFRELHLLMASLD
What is the function of this protein?
Participates in a complex which severs microtubules in an ATP-dependent manner.  May act to target the enzymatic subunit of this complex to sites of action such as the centrosome.  Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.  Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.  The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules.  Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth.  Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins.  This transport is required for axonal growth.
What are the official names of this protein?
Katanin p80 WD40 repeat-containing subunit B1, Katanin p80 subunit B1, p80 katanin.
What is the protein family that this protein belongs to?
Belongs to the WD repeat KATNB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity).
Protein: SCMC1_HUMAN
Sequence: MLRWLRDFVLPTAACQDAEQPTRYETLFQALDRNGDGVVDIGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK
What is the function of this protein?
Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane.  Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter.  By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (PubMed:15123600, PubMed:22015608).  In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600).  May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates (PubMed:22015608, PubMed:29100093).
What are the official names of this protein?
Mitochondrial adenyl nucleotide antiporter SLC25A24, Mitochondrial ATP-Mg/Pi carrier protein 1, Mitochondrial Ca(2+)-dependent solute carrier protein 1, Short calcium-binding mitochondrial carrier protein 1, SCaMC-1, Solute carrier family 25 member 24.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: ASIP_CHLAE
Sequence: MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPE_TROWT
Sequence: MKTDGGNTWRASHSKPLNTANTMGEPFSHSEYSVHADQSEFYLNELTEHSGQDNPCMNTSRLNTNRYGHPVVHPCPKIHCICTQSNIAAIGSDCTGCVDIAQACKMLRGGLGCTQDPCVKNPHTQCFTDVSNHAMRNVLPLNVSNTEQFPIQIEYANGRNPVLNPMDDLAMRAALLLSKDIDLQNTHILPSTRISIEKNIPVAAGLAGGSADAAAVLLGINSAWQTNYSRCDLLGKAGALGADVPFLIWGGAAYGSGTGSCVTFFETQTLYWVLCFSKHPLSTRKVFQELDRQRSGAGCNHHPVFSNPAECAEMLKKAIKRGPEALAALLHNDLTSAAKMLMPEIAERIKAAERCPGILRAIISGSGPTLALLAEDAEAANRACSILKDTGVICKAVSSPAYSSIYWQT
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PG025_VACCW
Sequence: MVNDKILYDSCKTFNIDASSAQSLIESGANPLYEYDGETPLKAYVTKKNNNIKNDVVILLLSSVDYKNINDFDIFEYLCSDNIDIDLLKLLISKGIEINSIKNGINIVEKYATTSNPNVDVFKLLLDKGIPTCSNIQYGYKIKIEQIRRAGEYYNWDDELDDYDYDYTTDYDDRMGKTVLYYYIITRSQDGYATSLDVINYLISHKKEMRYYTYREHTTLYYYLDKCDIKREIFDALFDSNYSGHELMNILSNYLRKQFRKKNHKIDNYIVDQLLFDRDTFYILELCNSLRNNILISTILKRYTDSIQDLLLEYVSYHTVYINVIKCMIDEGATLYRFKHINKYFQKFGNRDPKVVEYILKNGNLVVDNDNDDNLINIMPLFPTFSMRELDVLSILKLCKPYIDDINKIDKHGCSILYHCIKSHSVSLVEWLIDNGADINIITKYGFTCITICVILADKYIPEIAELYIKILEIILSKLPTIECIKKTVDYLDDHRYLFIGGNNKSLLKICIKYFILVDYKYTCSMYPSYIEFITDCEKEIADMRQIKINGTDMLTVMYMLNKPTKKRYVNNPIFTDWANKQYKFYNQIIYNANKLIEQSKKIDDMIEEVSIDDNRLSTLPLEIRHLIFSYAFL
What is the function of this protein?
Plays a role in the inhibition of host immune repsonse by counteracting the action of interferons on early events in the viral replication cycle.
What are the official names of this protein?
Ankyrin repeat protein OPG025.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG025 family.
Protein: MED1_CANGA
Sequence: MADQYVEVLGDLIGLLKDYKPGTITIENITKLCQSMGLESFIDELDNDISRLSTASKIIVIDIDYNKTQSTVQDVKLVLASNFDNFDYSNEQLEEAGDKQSNILLNSLTNYDSLKQFHHNLEFLYLLDTYSSVESDNQISSGNNLGSGNGTNGSSLTNKTDKKSVSSGNGLDSKLNEGKLNLFKYFRELKKYINTFFKESCDNRFKVVANVDNRFGLYIYETHGYSMRSRPLAKVYFERAKVPQQRFYEYIYSSETGSWINENSENYSVGVNLILEVNFDDTDEDVFWFPKEFVPTDLFIDEKDQLTSRKVSDVLCHAFYELGSSKKQTIELMNDFTTDLIQIRRFNINNDNLDLIADILNWTIWYRTVLRPIYLKLVSSISDDDDQHIRADIANTKDEFTVENTNPEIMKGPTNKNASFMQRNSMSLQRRRRSSNKAKRPSMSEAVVFKDEGLQQFSLHEIMADTTTEPDQKPDNLNISNNSESFIGQQELMEGSNIINDDKMDIDEEAINDDDSDSQSGEEGNIPVLLVNEDHVSFKGLGSCSFYDDKDKWAKFVEDLFNVFS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 1, Mediator complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FB269_ARATH
Sequence: MESRKTFDSIPDDLFVEIALRLSSKSIARCRCVSKLWASILYRQDFTELFITKSSARPRLLFAVLKASGLIFYSSPQSQNPSLEVDFHNHMKFHEDMNLYMCSYVSGFDPIGKQHKVLCMNKRLNKEWVHYILTLGTENLKWRKMICPLTHEPYYGRALSINGVLYYFARTSCFLVVSFNVRSEKFKFLDGKDFSNFHREFINYKGKLGVTKLECDAGDGHPRELCVWVLEDVEKQEWSQYIYSLPKIKVNRIRNDNIFAMFLPLTI
What are the official names of this protein?
Putative F-box protein At5g38810.
Protein: EIF2D_HUMAN
Sequence: MFAKAFRVKSNTAIKGSDRRKLRADVTTAFPTLGTDQVSELVPGKEELNIVKLYAHKGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVMPPAGLPQVQKGDLCAISLVGNRAPVAIGVAAMSTAEMLTSGLKGRGFSVLHTYQDHLWRSGNKSSPPSIAPLALDSADLSEEKGSVQMDSTLQGDMRHMTLEGEEENGEVHQAREDKSLSEAPEDTSTRGLNQDSTDSKTLQEQMDELLQQCFLHALKCRVKKADLPLLTSTFLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQQMQQEQIIQVKELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSFLEGSEVRTIVINYAKKNDLVDADNKNLVRLDPILCDCILEKNEQHTVMKLPWDSLLTRCLEKLQPAYQVTLPGQEPIVKKGRICPIDITLAQRASNKKVTVVRNLEAYGLDPYSVAAILQQRCQASTTVNPAPGAKDSLQVQIQGNQVHHLGWLLLEEYQLPRKHIQGLEKALKPGKKK
What is the function of this protein?
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner.  The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs.  Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety.  Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit.  In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
What are the official names of this protein?
Eukaryotic translation initiation factor 2D, eIF2d, Hepatocellular carcinoma-associated antigen 56, Ligatin.
What is the protein family that this protein belongs to?
Belongs to the eIF2D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_SYNJB
Sequence: MARQQRRGRKVKKNIPNGVAYIQSTFNNTIVTITDPNGDVVSWASAGSTGFKGAKKGTPFAAQMAAESAARQAMENGMRQIEVMVSGPGAGRETAIRALQATGLEITLIRDITPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: TNNI2_CHICK
Sequence: MSDEEKKRRAATARRQHLKSAMLQLAVTEIEKEAAAKEVEKQNYLAEHCPPLSLPGSMQELQELCKKLHAKIDSVDEERYDTEVKLQKTNKELEDLSQKLFDLRGKFKRPPLRRVRMSADAMLRALLGSKHKVNMDLRANLKQVKKEDTEKEKDLRDVGDWRKNIEEKSGMEGRKKMFEAGES
What is the function of this protein?
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
What are the official names of this protein?
Troponin I, fast skeletal muscle, Troponin I, fast-twitch isoform.
What is the protein family that this protein belongs to?
Belongs to the troponin I family.
Protein: CHZ1_SCHPO
Sequence: MSEEPKKIDIKGKGRAIEDLIPDIDDEEDDVDFQDLSSSGESDDSDDSMQEDYDDIHDEEPEDYSAIDPTNIMCSTRTRRKKIDFTKVLEEGQNEDDFEEEDEDYIPPQDKTM
What is the function of this protein?
Forms a chaperone-bound H2A. Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A. Z histone replacement in chromatin.
What are the official names of this protein?
Histone H2A.Z-specific chaperone chz1.
What is the protein family that this protein belongs to?
Belongs to the CHZ1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HTPX_MYCSK
Sequence: MTWNPHANRFKTFLLLVGMSALIVFVGSLFGRSIMALAVLFAVGMNVYVYFNSDKLALKAMHAQPVSELQAPVMYRIVRELSNAAHQPMPRLYISDTANPNAFATGRNPRNSAVCCTTGILQILNERELRAVLGHELSHVYNRDILISCVAGAMASVITALANIALFAGMFGGNREGTNPFALLLVSFLGPIAATVVRLAVSRSREYQADQSGAELTGDPLALASALRKISGGVEAAPLPPQPQLADQAHLMIASPFRSGEKIGKLFSTHPPMADRIRRLEEMAGRGPGLY
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCH4_PSEAB
Sequence: MNALTLPDIARQTTTADLPLDWVGMQGIALPVQIGGQRVAAEADAGVSLDDPQARGIHMSRLYLALAELEQGELDLSRLRAVLQRFLDSHAGLSRRAYLRLRLAPLLRRPALVSPLSGWKRYPLVLDTRLEGDDFQAEVHLELTYSSTCPCSAALARQLIQERFDQDFAGQPLDHASVLAWLGSSAGIVATPHSQRSSAHLRIGLAEDCIGLPLEELADLGESALGTAVQTAVKRADEQAFALANGQNLMFCEDAVRRLHRALQGYPQASRFSIRVVHAESLHAHDAVAESHWQRGAA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: GATD_THEAC
Sequence: MERAVLRYKNSVISGLIINESNGLITLKASNGYNMTFDRSEVEFIERKKEESPERKSIEAVEKGQGDRKISVLATGGTIASRVDYETGAVSPVSDPELIFGGSDILTRFTVAVKPILNEFSENLKPADWIRIGQAVADESSEADGVVVAHGTDTMAYTSSALAFMFERMRVPVVFVGAQRSSDRPSSDSRENMQAAINFAGTDLGEVGISMHASTSDGHVSLLRSVRSRKMHTSRRDAFESIGIPPLAEYDGSVKFLIDYRRVSDTVEFRPDLDDRVSMIYFHPGLNAGDLENMIAEKHAVVILGTGLGHMAKDLIPVVKKYTADGNYAIMASQCIYGSTDLNVYSTGRELLAAGVIEAGNMVPEVAYVKAMYLLGQYPHDLFRDLFRKNMRGEIVERDLPVEIIKLGR
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit D, Glu-ADT subunit D.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family. GatD subfamily.