PharMolix/UniProtQA huggingface dataset:
Protein: RSAD2_SINCH
Sequence: MQFSPVVASPKLLLQLCISTLHCIMASIISTVCYWTAGACKGTTSPVPPVDSNLDQRKVQNAMTPTSVNYHFTRKCNYKCGFCFHTAKTSFVLPLEEAKRGLKLLKESGMEKINFSGGEPFLHEKGEFLGKLVQFCKLDLQLPSVSIVSNGSMIKEKWFQKYGDYLDILAISCDSFDEATNQLIGRTQGRKSHVDNLHKIRNWCQQYKVAFKINSVINTFNMDEDMTEPITQLNPVRWKVFQCLLIDGENAGEEALREAERFVISDQLFQEFLDRHSSISCLVPESNEKMRNSYLILDEYMRFLDCRAGRKDPSKSILDVGVKDAISFSGFDEKMFLKRGGKYVWSKANMKLQW
What is the function of this protein?
Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon.
What are the official names of this protein?
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2, SAND, Radical S-adenosyl methionine domain-containing protein 2, Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible, Viperin.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RSAD2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RK33_CHAVU
Sequence: MAKSKDTRITIILECNICSNNKKSNFPKSSRYTTQKNRRNTPNRLILKKFCSNCQQHTIYNEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ATP6_HYLLA
Sequence: MNENLFTSFATPTILGLPAAVPIILFPSLLIPTSKYLINNRLITTQQWLIQLTLKQMMTMHNTKGRTWSLMLISLITFIATTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGTVATGFRLKAKNTLAHLLPQGTPTPLIPMLIIIETISLFIQPVALAVRLTANITAGHLLMHLIGAATMALSTISLPATPIIFTVLTLLTTLEIAVALIQAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EZY3_CHLRE
Sequence: MAAVVGTGSDGGGDESGDRRTADAADADGDGDGGERAWLRFKADVRACLADLRNRKGGITLHRAIVKDMVSASSNPGARRSSSSVVKMAREELDRLMPFLLDDFLDNMPGLKAAFTGKAEPGAEGDDGEDEEEGEAQGVGKDAVDSSSSSSGGGGVLSCTAWQQVLGRTVPAVSPTLALVLACGYLAMAPRQYRALALVPMILPGKTGGGVDGALTREGLSLLKKLRPGISGLADKDKQWLEWVIARLAAEFAVQPAGDGHEPEPKRPELPPTAVQREPPAEEQHKPTAGARDSPNM
What are the official names of this protein?
Ezy-1 protein.
Protein: GNAQ_MOUSE
Sequence: MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:9687499).  Required for platelet activation (PubMed:9296496).  Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (PubMed:20624888).  Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (PubMed:17938235).  Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity).  Together with GNA11, required for heart development (PubMed:9687499).
What are the official names of this protein?
Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(q) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Golgi apparatus. Nucleus. Nucleus membrane. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Protein: SBCD_STAAR
Sequence: MKIIHTADWHLGKILNGKQLLEDQAYILDMFVEKMKEEEPDIIVIAGDLYDTTYPSKDAIMLLEQAIGKLNLELRIPIIMISGNHDGKERLNYGASWFENNQLFIRTDFTSINSPIEINGVNFYTLPYATVSEMKHYFEDDTIETHQQGITRCIETIAPEIDEGAINILISHLTVQGGKTSDSERPLTIGTVESVQKGVFDIFDYVMLGHLHHPFSIEDDKIKYSGSLLQYSFSEAGQAKGYRRVTINDGIINDVFIPLKPLRQLEIISGEYNDVINEKVHVKNKDNYLHFKLKNMSHITDPMMSLKQIYPNTLALTNETFSYNEENNAIEISEKDDMSIIEMFYNHITDKELSDIQSNKIKNILENELRKED
What is the function of this protein?
SbcCD cleaves DNA hairpin structures.  These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions.  The complex acts as a 3'->5' double strand exonuclease that can open hairpins.  It also has a 5' single-strand endonuclease activity (By similarity).
What are the official names of this protein?
Nuclease SbcCD subunit D.
What is the protein family that this protein belongs to?
Belongs to the SbcD family.
Protein: APOC3_MIRAN
Sequence: MQPRVLLVAALLVLLASARALEAEDPSLLDLMQGYMQHATKTAQDTLTSVQESQVAQRARDWMTDGFSSLKDYWSTFKGKFSGFWDSASEAQTTPASDAS
What is the function of this protein?
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma.  Plays a multifaceted role in triglyceride homeostasis.  Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs).  Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.  Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
What are the official names of this protein?
Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NQRF_SERP5
Sequence: MEIILGVAMFTGIVMVLVLLILFAKSRLVNTGDIAVEVNGDLDKSFTAPAGDKLLNMLSSQGIFVSSACGGGGSCGQCRVVIKEGGGDILPTELSHINKREAKEGCRLACQVNVKQNLKIELPEEIFGVKKWECEVISNDNKATFIKELKLKIPDGEDVPFRAGGFIQIEAPAHDISYADFDVPDEYRGDWDKFNLFRYRSVVNETTVRAYSMANYPDEKGIIMLNVRIATPPPRDPDVPPGIMSSYIWSLKAGDKVTISGPFGEFFAKDTDAEMIFIGGGAGMAPMRSHIFDQLNRLKSKRKITFWYGARSLREMFYEEDFNQLQAENENFTWHVALSDPQPEDNWTGYTGFIHNVLLENYLRNHPAPEDCEFYMCGPPMMNAAVIKMLKDLGVEDENIMLDDFGG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit F, Na(+)-NQR subunit F, Na(+)-translocating NQR subunit F, NQR complex subunit F, NQR-1 subunit F.
What is the protein family that this protein belongs to?
Belongs to the NqrF family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SECM_ECOL5
Sequence: MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: COMB_SYNSC
Sequence: MQISYFHVPAEMPQDLRPDAAVVIDVLRATTTIARALHNGAEAVQAFASLEDLRAAAAEWPADARLLLGERGGQMLEGFDLGNSPVAVTPEQVAGKRLFMSTTNGTRALDRVREVPLLLTAALPNREAVAQRVLAKQPSHVAIVGSGWEGAYSLEDSLAAGALGHRLLELDPTGSSAANDELTAAVSLWRQWQSDPEACLRTATHGQRLIRLGDHDADFRCCAGLDQLGVVPTQVEPGVLRAA
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: S41A1_PONAB
Sequence: MSSKPEPKDVHQLNGTGPSASPCSSDGPGREPLAGTSEFLGPDGAGVEVVIESRANAKGVREEDALLENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQVLFPFLLAGFGTVAAGMVLDIVQHWEVFQKVTEVFILVPALLGLKGNLEMTLASRLSTAANIGHMDTPKELWRMITGNMALIQVQATVVGFLASIAAVVFGWIPDGHFSIPHAFLLCASSVATAFIASLVLGMIMIGVIIGSRKIGINPDNVATPIAASLGDLITLALLSGISWGLYLELNHWRYIYPLVCAFFVALLPVWVVLARRSPATREVLYSGWEPVIIAMAISSVGGLILDKTVSDPNFAGMAVFTPVINGVGGNLVAVQASRISTFLHMNGMPGENSEQAPRRCPSPCTTFFSPDVNSRSARVLFLLVVPGHLVFLYTISCMQGGHTTLTLIFIIFYMTAALLQVLILLYIADWMVHWMWGRGLDPDNFSIPYLTALGDLLGTGLLALSFHVLWLIGDRDTDVGD
What is the function of this protein?
Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane.  Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump.  Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (By similarity).  Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity).
What are the official names of this protein?
Solute carrier family 41 member 1.
What is the protein family that this protein belongs to?
Belongs to the SLC41A transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Protein: CNN2_MOUSE
Sequence: MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRSWIEGLTGLSIGPDFQKGLKDGVILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDHCTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQVFGLGRQIYDPKYCPQGSAADGAPAGDGQGEAPEYLAYCQEEAGY
What is the function of this protein?
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction.  It is capable of binding to actin, calmodulin and tropomyosin.  The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
What are the official names of this protein?
Calponin-2, Calponin H2, smooth muscle, Neutral calponin.
What is the protein family that this protein belongs to?
Belongs to the calponin family.
Protein: NGB_MOUSE
Sequence: MERPESELIRQSWRVVSRSPLEHGTVLFARLFALEPSLLPLFQYNGRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLTSLGRKHRAVGVRLSSFSTVGESLLYMLEKCLGPDFTPATRTAWSRLYGAVVQAMSRGWDGE
What is the function of this protein?
Involved in oxygen transport in the brain.  Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom.  Not capable of penetrating cell membranes.  The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase.  Involved in neuroprotection during oxidative stress.  May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.
What are the official names of this protein?
Neuroglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
What are the subcellular locations of this protein?
Perikaryon. Cytoplasm. Mitochondrion.
Protein: DBP7_MAGO7
Sequence: MDDDGLLINFEVGEGPIKPQIKFTGGRWRERNRLQRSVKRGLTGSQSNDAVADDVGPAPAKRQRLSEGAAPEIQRRFRPQAQGPRSQHVSSRLFTSNPTPVTNFDEPETAPAEEPAEPALPSNAPLSDEAATFAALGLSRRIAQHLSAKLELKAPTAIQHRAVPHLVTTDEDAFLQAQTGSGKTLAYLLPIVNRILALNQNEDGTISKDASKKIHRNSGLLAIVLAPTRELCKQIATVLEKLLRCAPWIVSTTVIGGESKHSEKARIRKGINILIATPGRLKDHLDNTKVLDVSLARWLILDEGDRMMEMGFMDDLKEIVSKMREAPLKKINPDGIQLEPALPTRRVTVLCSATLDHAQVRRLGEYSLEADKTELIKVDGTEAAKEGDEASEAVFAAPSQLKQSYLVVPAKLRLVTLIALLKSSFARRGSVMKAIIFISCADSVDFHFDLLRSPIKEPKEAAAPPTPKKAPKDAGETPDTPPKETKPTKPVTNHTESTVGKACYITSAANTTITLHKLHGSLAQPVRTATLDSFSKSKDPSILITTDISSRGLDVPAVDLVIEYDPAFAVADHVHRIGRTARAGRPGKAVLFLQPGSEEGYVGLLQKNASTALTPQLYDSVLQAGFSSNIDLPPVTATNEDGQDTEQQKQLDSRKQTWTSRAEALQLHLEQRLLASDASSQASNNSGKGFNSKKGASTKLGKPAPKSSDGATGTLLASGRQAFRSHIRAYATHVRDERVYFDMTQLHLGHMAKAFGLREAPGGIGAGVQRRTVKPSAANGGGKKSTKGDDGDGLDKQDDDEAERTRRMKKMMRMVGAGASEFNIG
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP7.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CIDB_STAAR
Sequence: MNDYVQALLMILLTVVLYYFAKRLQQKYPNPFLNPALIASLGIIFVLLIFGISYNGYMKGGSWINHILNATVVCLAYPLYKNREKIKDNVSIIFASVLTGVMLNFMLVFLTLKAFGYSKDVIVTLLPRSITAAVGIEVSHELGGTDTMTVLFIITTGLIGSILGSMLLRFGRFESSIAKGLTYGNASHAFGTAKALEMDIESGAFSSIGMILTAVISSVLIPVLIILFY
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
What are the official names of this protein?
Holin-like protein CidB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. CidB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NU2M_MAMPR
Sequence: MNPLALSLILTTLLAGTLITMMSSHWLTAWMGLEMNMLTMIPILMKTTNPRSTEAATKYFMTQATASMMLMMALTINLMYSGQWSIMKMTNPVASNVALMALMTKLGSAPFHFWVPEVTQGVELTSGMILLTWQKLAPLSLLYQMATYTNTNLIYLSGLLSILIGGWGGLNQTQLRKILAYSSISHMGWMLIILPFNPTLTLLNLAIYILLTLSIFMILANTLTTSMSSLTLMWNKTPAMTIMLMTTLLSLGGLPPLSGFTPKWLMIHELTKNNSIIMPLTMAIMTLLNMYFYMRLIYYSSLTILPSTNNMKMTWQFTSTKHTMMLPTLITLSNMLLPLTPMISMLE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PATH_DROME
Sequence: MVNIVDSGSKHAPQEMEQFLPGEGKVMYKIQPRKSDTEQALAGNDFDPFALRDNPHPTTDNETLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKCGHKLYYRTRRTKMTFAEIAEAAFQKGPKWCRGFAPVAKFSILFGLFLTYFGTCSVYTVIVASNFEQLISYWTGTAVSLRMLICIMLVPLILIAWVPNLKYLAPVSMVANVFMGLGLGITFYYLVQDLPPVEERESVVWSTLPQFFSITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQGMSGVTLIYMLLGFLGYLRYGSATGESITLNLPIEEWPAQTVKVLISLAVYCTFGLQFFVCLEIIWDGIKEKCKKRPTLVNYVLRTVLVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIFPVVIELIVHWESGFGKYNWILWKNAIITLCGIGALVFGTQAAIKDIVKAYSNNENVGE
What is the function of this protein?
Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline (PubMed:15843412).  Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway (PubMed:15843412, PubMed:22574197).  Required in a cell-autonomous manner for dendrite growth in neurons with large dendrite arbors (PubMed:26735916, PubMed:26063572).
What are the official names of this protein?
Proton-coupled amino acid transporter-like protein pathetic.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Perikaryon. Cytoplasm. Note=Localizes to endolysosomes in class IV da neurons.
Protein: TRPA_CHLL3
Sequence: MTQKKENRITARLREDRKLLLAYYMPEFPVAGSTLPVLEALQDGGADIIELGIPFSDPVGDGPVIQNAAHIAIRNGVSVRSLLELVRKARAGEGCRKITVPILLMGYSNPLIAYGGDCFLHDAVKAGVDGLLIPDLPPEESADFLQRAKSLGLTVVYLISPVTPPERIEWIDSLSTDFSYCLAVNATTGTAKLADASTEASVDRYLERVRLHARKKFVVGFGIRDRARVEHMWRLADGAVVGTALLEHIAGAPNPGEAARRAGEFWRGLR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: CARA_BACCR
Sequence: MKRQLILEDGTVLIGTGFGGEIEKSGEVVFTTGMTGYQETLSDPSYCGQIVTFTYPLIGNYGINRDDFESIHPSVNGLIVNEICNHPSNFRNEISLNDYLKERNIPGLAGIDTRKLTRKIRQYGTLRGRLCNMDADVEYIVSQLKATVFTDHVKRVSTKDPYPSPGRGHRVVLVDFGMKHGILRELNKRDCDVIVVPYNTTAEEILRLSPDGIMLSNGPGDPKDVPEAIEMLKDIIGKVPLFGICLGHQLFALASGANTSKLKFGHRGLNHPVKNLATGKVAITSQNHGYAVEEESVENTDLEITHVALNDGTVEGLRHKKFPAFTVQYHPEASAGPEDANDLFEDFLTMIENFKKEGEELCQNA
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: VIAA_YERPG
Sequence: MLSLATLDMLLSISEGELIEEMVVGLLAAPQLAIFFEKFPRIKRALMKDIPGWKQNLQQRIREASVPPGLANEFSLYQQSLLEDSPQFYAHLPDIVAQLQDLHSPFATQAKTLVQTADLAKNPPGGDSLQTLFLQRWRVSLILQTITIHHQLLEQEREQLLAELQRRLALSGALEPILTTNDNAAGRLWDMSQGHLQRGDYQLLLQYGDFLQQQPELIRLAEQLGRSRSAKAQPAPDARYEPYTVMVRQPDSVPEEVSGIHQSNDILRLLPTELVMLGMSELEFEFYRRLLERRLLTYRLQGDNWQEKTQQRPVSLKQNDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALLRIALADNRRCYIMLFATEIIHYELSADNGIEQAIRFLNQHFRGGTDLAACLANTLNKMEDREWYDADAVIISDFIAQRLPEELVRKIKIQQQAHQHRFHAVAMSAYGKPGIMRIFDHIWRFDTSLKSRLIRRWKR
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.
Protein: KRA61_SHEEP
Sequence: MCGYYGNYYGGLGCGSYSYGGLGCGYGSCYGSGFRRLGCGYGCGYGYGSRSLCGSGYGYGSRSLCGSGYGCGSGYGSGFGYYY
What is the function of this protein?
In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 6-1, Keratin, glycine/tyrosine-rich of hair.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 6 family.
Protein: USG_ECOLI
Sequence: MSEGWNIAVLGATGAVGEALLETLAERQFPVGEIYALARNESAGEQLRFGGKTITVQDAAEFDWTQAQLAFFVAGKEATAAWVEEATNSGCLVIDSSGLFALEPDVPLVVPEVNPFVLTDYRNRNVIAVPDSLTSQLLAALKPLIDQGGLSRISVTSLISASAQGKKAVDALAGQSAKLLNGIPIDEEDFFGRQLAFNMLPLLPDSEGSVREERRIVDEVRKILQDEGLMISASVVQAPVFYGHAQMVNFEALRPLAAEEARDAFVQGEDIVLSEENEFPTQVGDASGTPHLSVGCVRNDYGMPEQVQFWSVADNVRFGGALMAVKIAEKLVQEYLY
What are the official names of this protein?
USG-1 protein.
What is the protein family that this protein belongs to?
Belongs to the aspartate-semialdehyde dehydrogenase family.
Protein: MPEG1_PONAB
Sequence: MNNFRATILFWAVAAWVTSGKPLGEMDEVGVQKCKNALKLPVLEVLPGGGWDNLRNVDMGRVMELTYSNCRTTEDGQYIIPDEIFTIPQKQSNLEMNSEILESWANYQSSTSYSINTELSLFSKVNGKFSTEFQRMKTLQLKDQAITTRVQVRNLIYTVKINPALELNWSFRKELLDISDRLENNQTRMATYLAELLVLNYGTHVITSVDAGAALIQEDHIRASFLQDSQSSRSAVTASAGLAFQNTVNFKFEENYTSQNVLTKSYLSNRTNSRVQSIGGVPFYPGITLQAWQQGITNHLVAIDRSGLPLHFFINPNMLPDLPGPLVKKVSKTVETAVKRYYTFNTYPGCTDLNSPNFNFQANTDDGSCEGKMTNFSFGGVYQECTQLSGNRDVLLCQKLEQKNPLTGDFSCPSGYSPVRLLSQIHEEGYNHLECHRKCTLLVFCKTVCEDVFQVAKAEFRAFWCVASSQVPENSGLLFGGLFSSKSINPMTNAQSCPAGYFPLSLFENLKVCVSQDYELGSRFAVPFGGFFSCTVGNPLVDPAISRDLGVPSLKKCPGGFSQHLALISDGCQVSYCVKSGLFTGGSLPPARLPPFTRPPLMSQAATNTVIVTNSENARSWIKDSQTHQWRLGEPIELRRAMNDIHGDGGGLSGGAAAGVTLGVTTILAVVITLAIYGTRKFKKKAYQAIEERQSLVPGTAATGDTTYQEQGQSPA
What is the function of this protein?
Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores (By similarity).  By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity).  Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (By similarity).  Reduces the viability of the intracytosolic pathogen L. monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity).  Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity).
What are the official names of this protein?
Macrophage-expressed gene 1 protein, Macrophage gene 1 protein, Mpg-1, Perforin-2, P-2.
What is the protein family that this protein belongs to?
Belongs to the MPEG1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=Bacterial infection induces translocation of the cytoplasmic vesicles to bacterium-containing phagocytic vesicles and fusing of the vesicles.
Protein: ATPL_SALHS
Sequence: MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFIVMGLVDAIPMIAVGLGLYVMFAVA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.