PharMolix/UniProtQA huggingface dataset:
Protein: NPD_MYCLE
Sequence: MRVVVLSGAGISAESDVPTFRDDKNGLWARFDPYQLSSTQGWQRNPERVWGWYLWRHYLVANVKPNDGHRAIAAWQEQIEVSVITQNVDDLHERAGSTPVHHLHGSLFKFHCARCNVAYTGALPDMPEPVLEVDPPVCYCGGLIRPAIVWFGEPLPDEPWRRAVEATETTDVMVVVGTSAIVYPAAGLPELALSRGAVVIEVNPEPTPLTKNATISIRETASQALPGLLQRLPALLK
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_ALIB4
Sequence: MEYISKDIEKKWQNFWSENQSFEPSSSKTKEKKYILSMFPYPSGRIHMGHVRNYCIGDAFARHFRKSDFNVLHPIGWDSFGMPAENAAIKHKLHPKKWTYENIDYMRDELKSLGLSFSKNREFATSDELYTKWEQEFIIKMYEAGIIYRKSATVNWCPHDQTVLANEQLEEGCCWRCGTEVVQKEMPGYYIGITKYAQELLDDLEKLKEDWPSQVLTMQENWIGRSEGLEFKFDLSKESRAKLERAFTKYFVFTTRPDTIYGVSYSALAPEHPIVKYIVEKNLLPEKKIKAIKAMQKIPERDRATQEKEGIDLEIEVMHPLTGKTIPVWVANFVLSSYGGGAVMAVPAHDQRDFEFAKKYNLPIKQVIVGPDGIIENQTEAYTAEGRLIESENFTGVTNIEAKKAIIYHFEQNSFGIKKVNYKLRDWGVSRQRYWGAPIPFIHCEKCGLVPEKIENLPVALPEDVEITGEGNPLDTHPTWKHCTCPKCGEKATRETDTLDTFVQSSWYFLRYATDNKKWNEVGISKEDSDYWMDVDQYIGGIEHAILHLLYARFFTKVLRDLGYTNSSEPFKKLLTQGMVLKDGAKMSKSKGNVVDPDLIIDKYGADTARLFILFAAPPTKELEWNDSAVEGAFRFIKKFFERAENVNQNGLDNFKSIDHSALSKEEKEARKKVYEALLKSNEVFTKTYTFNTLIASCMEALNALQTQKNDSIWAEGYYILTNILEPIIPHACWELSKKLFDLKNFDGKIELKEEVFALESIILAVTVNGKKRCEIEVAPDTSKDEILVKAKIASAKWLENSEILKEIVVPNKLVNFVIKG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR18_RAT
Sequence: MAAPMEVVVCTDSAAPLWSCMVWELHSGANLLTYRGGQAGPRGLALLNGEYLLAAQQGKNYICAWELQRKDQLQQKIMCPGPVTCLTTAPNGLYVLAGIAESIYLWEVSTGNLLVILSRHYQDVSCLKFTGDGSHFVSAGKDCLVLAWSLCSVLQADPSRILAPRHVWSQHTLPITDLHCGFGGPMARVATASLDQTMKLWAISSGDLLLSVLFDMGITSVTMDLAEHYIFCGGSDGSIFQVDLCSRPGPREQSFQPEQNTGKVFKGHRNQVTCLSVSTDGSILLSGSHDESVRLWDVKSKQCVRTVPLKGPVTNAAITLAPPSMLNPEFRPSLPLPHFNKHLLGAEHGDEAQGGGLRLQLGLHLQGKEPSYLERLEQLQAALSGYLEKNMLGSQMLPVRVFELEEEVRSLRKINRDLFDFSTRIITRPSK
What is the function of this protein?
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity).  Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity).  May play a role during development (By similarity).
What are the official names of this protein?
WD repeat-containing protein 18.
What is the protein family that this protein belongs to?
Belongs to the WD repeat IPI3/WDR18 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Dynein axonemal particle. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
Protein: LRP6_HUMAN
Sequence: MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
What is the function of this protein?
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.  Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation.  The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.  Required for posterior patterning of the epiblast during gastrulation (By similarity).
What are the official names of this protein?
Low-density lipoprotein receptor-related protein 6, LRP-6.
What is the protein family that this protein belongs to?
Belongs to the LDLR family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Membrane raft. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6- signalsomes. Chaperoned to the plasma membrane by MESD (By similarity).
Protein: DRS1_CANAL
Sequence: MPDFILTIDSDEEVDVSDSEQLQDINPDFKFQIDGETTNTLEEFDFQENKVKEVDLDEIIKKKGGLKEESDDEELALDGFGMGASKQEEEEEEEEEEVEVPEVKEVVEPEDSAEAIADFYEESSPQQTHTSFQTLQLSRPVLKGIAELKFTKPTPIQSASIPIALLGKDIVAGAQTGSGKTGAYMIPIIERLLYKPSTSTKVIILTPTRELALQVYEFGKKLSHHVNNLNIGLAVGGLNLRQQEEQLKTRPDIVIATPGRLIDHIRNSPSFSVQDIQVLVIDEADRMLEEGFQDELTEILSLIPKHKRQTLLFSATMNTRIQDLIQLSLQKPVRIMIDPPKSVASKLLQQFVRIRKRDQLKPALLYQLLKGVSSRVVVFVARKETAHRLRIVLGLLGLKVSELHGALTQEQRLQNVKNFKSLEVPVLICTDLAARGLDIPKIELVINYDMPKTFEIYLHRVGRTARAGRDGTSITFVGESSQERAIVKSAIVNGKGVAKTVDWKQAEETNKLLESKESVIDEVLEEEKEAKELLRAEMELTKASNLIKHEQEIHSRPKRTWFKGEVMEQLTKHGKKVNSKKRKANEVRKDEGRSYKKTKTDRMKISNKKKSKK
What is the function of this protein?
ATP-binding RNA helicase involved in ribosome assembly.
What are the official names of this protein?
ATP-dependent RNA helicase DRS1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: VTF3S_VACCA
Sequence: MFEPVPDLNLEASVELGEVNIDQTTPMIKENSGFISRSRRLFAHRSKDDERKLALRFFLQRLYFLDHREIHYLFRCVDAVKDVTITKKNNIIVAPYIALLTIASKGCKLTETMIEAFFPELYNEHSKKFKFNSQVSIIQEKLGYQFGNYHVYDFEPYYSTVALAIRDEHSSGIFNIRQESYLVSSLSEITYRFYLINLKSDLVQWSASTGAVINQMVNTVLITVYEKLQLVIENDSQFTCSLAVESKLPIKLLKDRNELFTKFINELKKTSSFKISKRDKDTLLKYFT
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from intermediate gene promoters.
What are the official names of this protein?
Intermediate transcription factor 3 small subunit, VITF-3 32 kDa subunit, VITF-3 small subunit.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG134 family.
Protein: TM2D1_HUMAN
Sequence: MAAAWPSGPSAPEAVTARLVGVLWFVSVTTGPWGAVATSAGGEESLKCEDLKVGQYICKDPKINDATQEPVNCTNYTAHVSCFPAPNITCKDSSGNETHFTGNEVGFFKPISCRNVNGYSYKVAVALSLFLGWLGADRFYLGYPALGLLKFCTVGFCGIGSLIDFILISMQIVGPSDGSSYIIDYYGTRLTRLSITNETFRKTQLYP
What is the function of this protein?
May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.
What are the official names of this protein?
TM2 domain-containing protein 1, Amyloid-beta-binding protein, hBBP.
What is the protein family that this protein belongs to?
Belongs to the TM2 family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: NPD_PROMH
Sequence: MMKLKLRHRRLRKFRKIKSLRRQHSRCRYFHLTHKTEHEMNLPKVVVLTGAGISAESGIKTFRSEDGLWEEHRVEDVATPEGYHRNPKLVQQFYNERRRQLQQPSIQPNEAHYALAKLEQYLGKDNFLLVTQNIDNLHEKAGSKHILHMHGELLKVRCPQSGQVFEWKGDLSTTDYCHCCQFPSPLRPHIVWFGEMPIGMDEIYHALAQADLFIAIGTSGNVYPAAGFVHEARLTGAHTVELNLEPSLVESEFEEKHYGPASQVVDAYVHKLFDLINDPKADLTQ
What is the function of this protein?
NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins.  Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation.  Modulates the activities of several proteins which are inactive in their acylated form.  Catalyzes deacetylation and de-2-hydroxyisobutyrylation of Eno at 'Lys-326' and 'Lys-343', respectively, thereby promoting the enolase activity.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCS2_BRASO
Sequence: MDPKILERLRLGLSDDERRLVIRSATGGEEVTEYSFGIEEEYFLVDAKTLDVAIRTPDDLFDAANWSTGGQAMREMLQAQLEVATNVHVDVGDAREELKFLRREVASVAGQYGLTILACSTHPTALWRNSQPTPKPRYAEMMEDLRIVGQRNMLCGMHVHVQLPDPDRRFAVMRAMIPYIPVFIALSASSPFWNSRETGLKGYRLAAYDELPRTGLPELFTSKKQYDRYVAALTKSGVMPDESHVWWAMRPSLRHPTLELRAPDVCTAVDDAVAIASLYRALARHLYLNPELADAVGNVERAIAVENKWRAQRYGTDCLFVTEDGPVTGQEILNRTIADVAEHAEALGCLAEVERCRTIMQFGSSADYQLQAYRESGGQLAAVTQWIAAATVSRAEPPQSQPSVEPVR
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: NTPTH_THEKO
Sequence: MALRIFVTGPAGVGKTTLVERVAREVDRWGYIVGGVITREVRRGGRRIGFKITALDTGEEGTLASLRGTSHLPGVPFGKYVVHVDEIERVAVPAIRRAIVEADLIVIDEIGPMEYTSNEFIRAVGEVLKSEKPLLAVVHRKFIDRFRPLGEVHTLSFENRNAEFGIILDRVMKELKGIRG
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: RL34_GEOUR
Sequence: MKRTYQPSNVSRKRTHGFLVRMSTKNGRLVIKRRRAKGRKNLAVSIASK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: DAPB_SODGM
Sequence: MSNTSIRIAVAGAGGRMGRQLIQAVAQSEQATLGAALTRTDSALCGVDAGELAGIGALGVAISGELAAVKDDFDILIDFTRPDASMAYLAFCRRHHKGIVIGTTGFSDAQKEAIRAEAQETGVVFAANFSVGVNLMLKLLEKAAQVMGEEADIEIIEAHHRHKVDAPSGTALAMGEAIAGALGRDLARCAVYSREGHTGERKAKSIGFATVRAGDIVGEHTAMFAEIGERLEITHKASSRMTFASGAVRAAVWLSGQKRGFFDMVNVLNLDKI
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLA_METCA
Sequence: MPAFRYLIVLPLLCWGFASQAETTPQSRLKSFLDSARTLQADFTQVRLDESGRPRQESGGSFYLQRPGKFRWDYTKPYRQQIVSSGGKVWFYDVDLEQVTAKRLGQAVGSTPALLLSGEMALEDNFTIEDQGTEEGMYWIKLVPKSEEGGFRYVLIGLEGDKLAGMELSDNFGQLTRIYFANLRTGITLDPKLFQFSPPAGVDVFEDK
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ULK3_RAT
Sequence: MAGSGWGLPRLDGFILTERLGSGTYATVYKAYAKKATREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPSHRISFQDFFAHPWVDLEHMPSGESLAQATALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTTGQELLREMARDKPRLLAALEVASAAMAKEEEAGKEQDALDLYQHSLGELLLLLAAEAPGRRRELLHTEVQNLMARAEYLKEQIKIRESHWEAESLDKEGLSESVRSSCTLQ
What is the function of this protein?
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.  Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3).  Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation.  Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.  Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to pre- autophagosomal structure during cellular senescence.
Protein: LEUD_STRGG
Sequence: MEAFTTHTGRAVPLRRSNVDTDQIIPAHWLKKVTRDGFEDGLFEAWRKDENFVLNRPERQGASVLVAGPDFGTGSSREHAVWALQNYGFKAVISSRFADIFRGNSLKNGLLTVVLEQSVVDALWELSEADPTAEVTVDLEARQVRAEGITADFELDENARWRLLNGLDDISLTLQNEADIAAYEAARPAFKPRTIAA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: GPDA_FRATT
Sequence: MQKNILVLGAGAWGTALALQLAYRGHNVRINSWKAEHNEQMLKDNNNHKYLPSIEKFPSRLKAIQDWQANIIEFDSILVATPSSGFKNTILELKECILPQQNIISATKGFCHDSYALLSEIAEDILPTTKFALLTGPSFAKELANQLPTAVVVASKDINYARYVQELFSNENFRCYTTTDIIGAQVGGAVKNVLAITAGIAAGMEFGVNAHAALITRGLAEIKKLGLKLGANSETFIGLSCLGDLLLTCSDNQSRNRRFGLYLGQGMTIQQALKEVNNVVEGYFTAKAVYNLAKKHNVEMPLVFATYRILYEAADPRDIVKELMTRQLKNEN
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAC_ECO24
Sequence: MNNNLQGDAIAAAIDVLNEERVIAYPTEAVFGVGCDPDSETAVMRLLELKQRPVDKGLILIAANYEQLKPYIDDTMLTDAQRETIFSRWPGPVTFVFPAPATTPRWLTGRFDSLAVRVTDHPLVVALCQAYGKPLVSTSANLSGLPPCRTVDEVRAQFGAAFPVVPGETGGRLNPSEIRDALTGELFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIX_HAEIN
Sequence: MKIKKLLKNGLSLFLTFIVITSILDFVRRPVVPEEINKITLQDLQGNTFSLESLDQNKPTLLYFWGTWCGYCRYTSPAINSLAKEGYQVVSVALRSGNEADVNDYLSKNDYHFTTVNDPKGEFAERWQINVTPTIVLLSKGKMDLVTTGLTSYWGLKVRLFFAEFFG
What are the official names of this protein?
Thioredoxin-like protein HI_1115.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SNX17_RAT
Sequence: MHFSIPETESRSGDSGGSTYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL
What is the function of this protein?
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels.  Binds to NPxY sequences in the cytoplasmic tails of target cargos.  Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits.  Also required for maintenance of normal cell surface levels of APP and LRP1.  Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
What are the official names of this protein?
Sorting nexin-17.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PA2A_PROEL
Sequence: MRTLWIMAVLLLGVEGGLWQFENMIMKVAKKSGILSYSAYGCYCGWGGRGTPKDATDRCCFVHDCCYGKVTGCNPKLGKYTYISENGDIICGGDGPCKEVCECDRAAAICFRDNLDTYDRKTYWKYPASNCQEDSEPC
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 PePLA2, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: VES_CITK8
Sequence: MEYFDIRKMPVNLWRNGAGETREICCFPPATRDFHWRASIASIAGNGEFSLFPGVERVITLLEGGEVMLEGVNAFTHTLKRHQPFTFAGDSVVKATLSEGQMSMDLNIMTRRDRCKAKVRVADRTFTTFGSRGGVVFVISGAWQLGDKLLTADQGACWHDGKHTLRLLKPEGQLLFSEITWLPGYTPDTVQ
What are the official names of this protein?
Protein Ves.
What is the protein family that this protein belongs to?
Belongs to the Ves family.
Protein: O16A_CONLI
Sequence: VLIIAVLFLTASELVTADYTRDKWQYRAASLRDAMRNFRDTRTCSPAGEVCTSKSPCCTGFLCSHIGGMCHH
What are the official names of this protein?
Conotoxin LvVIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRH_ALBFT
Sequence: MSVAKPAHKRILLKLSGEALMGDDQFGINHDTIVRMVDEIAEVTRLGVEVAVVIGGGNIFRGVAGGSVGMDRATADYMGMLATVMNALALGDTMNKAGLTARVMSAIAIEQVVEPYVRPKALQYLEEGKVVIFAAGTGNPFFTTDTAAALRGAEIGAEVVLKATKVDGVYTADPKKDPQATRYSKISFDDAMTQNLGIMDATAFALCRDQKLPIKVFSILKHGALKRVVMGQDEGTLVYA
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_CHLTE
Sequence: MKHHSLIFLTGFSGSGKSTIGPLLANSLGFEFIDLDREIELTAGKSINRIFAEDGEAAFRSLELRTLEKIGQQERMVVSLGGGVLENDRCFELIRSHGTLIYLKSSPEILTLRLQHKTDRPLLKGPDGRKLTREEIQQRIAELLKKREPRYLKADLVLFTDSKKIGASVEELTRKIERHIRRASKNNTNEK
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAES_STAA3
Sequence: MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLERILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
What is the function of this protein?
Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion.  Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR (By similarity).
What are the official names of this protein?
Histidine protein kinase SaeS, Sensor protein SaeS, Staphylococcus exoprotein expression protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMN_METPP
Sequence: MTAANLLEFDLDALAAFCEQLGEKRFRATQLFRWIHQKGQSDFAQMSDLAKSLREKLAGRAVVRPLAVLSEHVSADGTVKWLFDVGGGNAVETVFIPENDRGTLCISSQAGCAVGCRFCSTGHQGFSRNLSTGEIVAQLWHAEHQLRARLGTTERVISNVVMMGMGEPLQNYAALLPALRVMLDDHGYGLSRRRVTVSTSGVVPMIDRLREDCPVALAVSLHAPTDALRDDLVPLNRKYPIAELLEACQRYLEAAPRDFITFEYCMLDGVNDSEAQARELLRLVGERGPVGRVPCKINLIPFNPFPASGLTRSSVARVQAFAQLLVDGGLVTTVRRTRGDDIDAACGQLAGEVQDRTNAQARMRRAPIAIRPIDSAVQRRADAAPSGSATETTR
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_MYCCT
Sequence: MILKDSTINNYATALFNIAVKEKLVDDYIIQVDALIQSLSDKDDFNKLVSFSNKQEKQDAILIIEKTFAPFEFDIYLINALKILVENQLFINTRMILKALYKKLLDYKNIVLGVVYSTEKLTKTQLSAIKKKISNKVNKKVELVNKIDPTLIGGIKVNVQGKVFDGSIKAKLEALKKQMNT
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.