PharMolix/UniProtQA huggingface dataset:
Protein: DBAB_EMENI
Sequence: MTRTSPTLPVIILGAGMVGLTLAQALKKAGIPYEVYERDSAADTEKGRGWALTVHWALNALEECLPAELFNRLEEIQVDPTLDDSRRFCFLDLSTAIPKYVIPPSKRLRVNRRLLGNLLGEGLDINYNKTLSSFHVSPETPDSVTVTFTDGTSTTGCLLVGTDGRNSKTRRLLLGEEAGALNPLPVRSIGTTITMTPEQFAPIREIDPLLFQGSHPETGVYMWFSLVSSPTINGSKDTPNPFYEGQLIQSWLYKSEKDAVPETDADRLALFKNNAQHFQRRLREAIETLPEDSKVLHIKLVDWVPVDWDNRGGRVTLAGDAAHAMTSYRGEAFNHGVADAAMLSRNIIAAWTNPGMTGGIADAPDSPIVSKRAKIAREARDARARAKLSEIAV
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives (PubMed:22510154, PubMed:23001671).  The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step (PubMed:22510154).  The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA (PubMed:23001671).  The roles of dbaB, C, E and F have still to be determined (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase dbaB, Derivative of benzaldehyde biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: PBGP9_SOLS1
Sequence: MKTLVFHIFIFALVAFASASRNSAKKIGSQYDHYQTCLTELGVTEDDLFSIGEVTSGQHKTKHEDTKLHRNGCVMQCLLEKAGLMTGADFDEEKMRENYIEEKGLQPGDQRIDFLNSCMEQTKDIEDKCDKSLIFIGCVLMNEVSLPASNEEA
What is the function of this protein?
Colony queen number, a major feature of social organization, is associated with worker genotype for Gp-9.  Colonies are headed by either a single reproductive queen (monogyne form) or multiple queens (polygyne form).  Differences in worker Gp-9 genotypes between social forms may cause differences in workers' abilities to recognize queens and regulate their numbers (By similarity).
What are the official names of this protein?
Pheromone-binding protein Gp-9, PBP, Putative odorant-binding protein Gp-9.
What is the protein family that this protein belongs to?
Belongs to the PBP/GOBP family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL31_PARDP
Sequence: MKADIHPDYHLIEVKMTDGTTYQVRSTWGKEGDTMSLDIDPNSHPAWTGGSAKLMDTGGRVSKFKNKYAGLGF
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: NUMB_RAT
Sequence: MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVGPSVAPGNSAPSPSSPTSPTLDPTASLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNTVPEVEGEAESISSLCSQITSAFSTPCEDPFSSAPMTKPVTLVAPQSPVLQANGTDSALHVLTAKPASTALAPVAMPVRETNPWAHAPDAANKEIAAIHSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPAAIAPPAPPFQGHAFLTSQPVPVGVVPPLQPAFVSTQSYPVANGMPYPASNVPVVGITPSQMVANVFGTAGHPQATHPHQSPSLAKQQTFPQYETSSATTSPFFKPSAQHLNGSAAFNGVDNSGLVSGNRPAQVPPGTCPVDPFEAQWAALESKPKQRTNPSPTNPFSSDAQKAFEIEL
What is the function of this protein?
Regulates clathrin-mediated receptor endocytosis (By similarity).  Plays a role in the process of neurogenesis.  Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate.  Not required for the proliferation of neural progenitor cells before the onset of neurogenesis.  Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity.  May also mediate local repair of brain ventricular wall damage (By similarity).
What are the official names of this protein?
Protein numb homolog.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to perinuclear endosomes in an AAK1-dependent manner.
Protein: AZOR1_LISMF
Sequence: MTNVLFIKANGLPAERSVSVALYEIFLTEYKKSHPDDNVTELDLFEADLPYYDVTMMSGLHKEAAGETLSPEEKRLADIANSYLDQFLAADKIVMAFPLWNFSIPAQFLTYLFYLNQAGKTFKYTANGPVGLVADKKIALLNARGGIYSDGPMQSFEMSLSYVKNVLAHFGISEPEMVIVEGHNAKPDQAKDIISAGAKEAVELAKIF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 1, Azo-dye reductase 1, FMN-dependent NADH-azo compound oxidoreductase 1, FMN-dependent NADH-azoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: BIOH_SALTI
Sequence: MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLVDLPGYGRSSGFGAMTLEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGIKPEILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLKSVVLAQPMPDVEVLNGGLEILKTVDLREALKNVNMPFLRLYGYLDGLVPRKIAPLLDTLWPHSTSQIMAKAAHAPFISHPAAFCQALMTLKSSL
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_YERPP
Sequence: MELVMKDAPGALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARAGSVKSPIWRSGGVTFAAKPQDHSQKVNKKMYRGALKSILSELVRQDRLIIVEKFSVEAPKTKLLAQKLKDMALEDVLIVTGELDENLFLAARNLYKVDVRDVAGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NRDI_STAS1
Sequence: MKVVYFSFSGNVRRFIKKAEITNTMEITQNNCTEKIEEPFILVTGTIGFGEVPQPVQSFLDINHDLLRGVAASGNRNWGQNFAKAGRSISEKYQVPLLMKFEVQGTQNDISEFKDKVGQFNEDYGREEIQSY
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: FABZ_COXB2
Sequence: MNVMNITDIKKYIPHRYPFLLIDRVIKIEKDKSLVAIKNVTVNEPFFTGHFPVRPVMPGVLIIESLAQAAGILIVKSLNLPEGHKDIYFFAGVDNARFKRVVEPGDQLTLEVKVLKVHRGLWKFEGKATVDDQLACKAELMTIKG
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKTHB_BUNFL
Sequence: MSSGSLLLLLGLLTLLAELTPVSSRKRHPDCDKPPNKKRCTGHIPAFYYNPQRKTCERFSYGGCKGNGNHFKTPQLCMCHCHE
What is the function of this protein?
Beta-bungarotoxin is a presynaptic neurotoxin of the venom.  The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic.
What are the official names of this protein?
Kunitz-type serine protease inhibitor homolog beta-bungarotoxin B chain.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: TVP18_ASPTN
Sequence: MTLAEEFRSRNFSIYGQWTGVICIILCLALGIANIFSFNAVRIVFSILCLVSGLILIFVEVPFLLRICPTSEKFDNFIRRFTTNWMRAAMYAIMSAVQWVSLVSGASGLIAAAVLLLIAALFYALAGLKSQDFVGSKTLGGQGIAQMIV
What is the function of this protein?
Golgi membrane protein involved in vesicular trafficking.
What are the official names of this protein?
Golgi apparatus membrane protein tvp18.
What is the protein family that this protein belongs to?
Belongs to the TVP18 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: STAM2_CHICK
Sequence: MPLSASNPFEQDVEKATNEHNNSEDWGLIMDICDKVGSTPNGAKDCLKAIMRRVNHKVPHVALQALTLLGACVSNCGRIFHLEVCSRDFATEARGIINKAHGKVSEKLKTLMVEWSEEFQKDPQCSLISATIKSLKEEGVTFPAAGSQATTNAAKNGSSLSKNKEDEDIRKAIELSLQEQKQQQMETKSLYPSAEIQQTNQNLRKVRALYDFEAVEDNELTFKSGEIIFVLDDSDTDWWKGENHRGVGLFPSNFVTSDLNVEPEAATVDNSCVPEDATEEIKKAEPEAVYIDEDKMDKTLQVLQSIDPTDLNLDTDLLDSEVICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLMNETPMYSAYSKLHHPAQYPPTSSGVSVQSYPVQPPSGNYMIQGVHQVTVSQGYGLGPDQMGQLRSLPQNINSSDCNLYTKSNRQRMCHMKAITTWQRFSKHTSER
What is the function of this protein?
Involved in intracellular signal transduction mediated by EGF.  As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization.  The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
What are the official names of this protein?
Signal transducing adapter molecule 2, STAM-2, Epidermal growth factor receptor-associated protein with SH3 and TAM domain.
What is the protein family that this protein belongs to?
Belongs to the STAM family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DEP2_FUSLA
Sequence: MHDSPPFKVIIVGAGVTGLTLAHCLVKAGIDYALLDKGVVAPGFGTTITLQPHGCRILHQLGCLDAVLAKCDVMGGASCRDPNGKIFTSNDFFGVVRKFAGYDTRTLDRQVFLHELYELLPDKSKVYEKARVEEIIEENSTTRVILADGREFAGDLVVGADGVHSKVREIMWDKANAAHPGMITVEEKRAMVTQYNAIVMASSPVPGISAHDMEVTSNDNYSFLLLCQPDWISIIVHSKLPDDQQCTWPTRRRYTETDMEELVSKIIERPVTGSVVFGELWKRRLKAQMISLEEGVLSHWTFGRIALAGDAVHKVTPNSALGGNTAMEDAVVIANTLHALLAMHPNKKPSDVEVRDAMREKYQNTRVDRARAIVKAGGDLTRQQAYDGWKAYIKQRWLTPIIGLDTLAQKIAGLCVTAPKLAYVDFDERRGILGWQDTLAAEKERESKTQVKVPIKQKKGLSWSTWNGGFEAIVPQILVLWAGLWLAICFFHLVFSGNHVPGFGSEVARFFTVYNETWMHS
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099, PubMed:28460114).  The reducing polyketide synthase DEP5 is the central enzyme in depudecin biosynthesis by yielding the backbone polyketide chain (PubMed:19737099).  The monooxygenases DEP2 and DEP4, as well as the uncharacterized protein DEP1, then act as tailoring enzymes to modify the intermediate polyketide chain into depudecin (PubMed:19737099).
What are the official names of this protein?
FAD-dependent monooxygenase DEP2, Depudecin biosynthesis cluster protein 2.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: EAF6_SCHPO
Sequence: MSTPNSTPSEPPVNVSYYEQCKKELHEMIEKRQLLETSLIGLEDSIYRLEGSYLEKTSGTGNIIRGFEGLLKNNASNLRRRADYSESDRLFSLSSLSSPHTRSPAYDLDDSTETSRRRKRKNESDSHEGRRRSSFREL
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).  Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.
What are the official names of this protein?
Chromatin modification-related protein eaf6.
What is the protein family that this protein belongs to?
Belongs to the EAF6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR18_BUXMI
Sequence: MDKSKRPFLKSKRSFRRRLPPIGSGDRIDYRNMSLISRFISEQGKILSRRVNRLTLKQQRLITIAIKQARILSSLPFLNNEKQFERTEFTARTTGSRTINLNK
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS5_PROM2
Sequence: MTDTPTKQETQSNKDNVPGAIPVEQKKNNRNDRKRNRRGDSKNLERDSDWQERVVQIRRVSKTVKGGKKMSFRAIVVVGNEKGQVGVGVGKAGDVIGAVRKGVSDGKKNLVRVPLTPNNSIPTLSKGRDGAANVLIRPAAPGTGVIAGGSIRTVLELAGIKNVLAKRLGSKTPLNNARAAMVALSQLRTHKSASRERGISLEQLYS
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: DAPA_LACP3
Sequence: MQKAELITAIVTPFNDRDEIDYGVMQRLVDHLIAEGTDGFVVGATTGEGPTLSHPEKITLYTRFADMVHGRALVIANSGSNNTKETAAFTHEVGGIAGIDATLVVVPYYNKPDQNGMIAHYTAVAAAAQKPIVIYNIPGRTGVDMLPATVATLAQNPMIQGIKQCGSLPALSDIIDRTKHDAFNVWTGEDAQALNIKTLGGMGVISVAAHLYAHSIREMYAALDRGDITTVAALQRQLLPKMAALFHFPSPAPTKAALNALGFQVGSPRLPLLPLNASQQQELAHLLGVPELSAIEAEVLA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RADA_METMJ
Sequence: MSEIDLEDLPGVGATTAEKLREAGYGTVESVATATTSDLAEAAEIGEATAKKVILAARKMADIGGFKTGRDILDKRKDIKKLRTLVPEFDELVGGGLETQAITEVYGEFGSGKSQLVHQMAVNAQLPEELGGLGGGVIYVDTENTFRPERIEQMLNGLPEEAEIGEIEEVLERIHVARAHSSDHQMLLLETARELANDLRTSDYPVRLFVIDSLTSLFRSEYAGRGTLAPRQQKLNRHMHDLLKLIDDHNAVGLVTNQVMSNPGILFGDPTKPIGGNIVGHTATFRLYLRKSKGGKRVARLVDSPNLPEGEAAFMVEQAGLKPC
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  Binds and assemble on single-stranded DNA to form a nucleoprotein filament.  Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
What are the official names of this protein?
DNA repair and recombination protein RadA.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family.
Protein: GRPE_BRUME
Sequence: MADEKNKPENPDLDQRDINNPRDREALKQAADDFLKARRAEAAADEAEGEVDETANRIAVLEADNTELKDQMLRVAAEMENLRKRTQRDVQDARAYAITNFARDMLSVSDNLRRALDAIPADALEADSNLKSLSEGVEMTERAMLLALERHGVKKLEPEGQKFDPNFHQAMFEVPNPDLPNNTVVQVVQAGYAIGDRVLRPAMVGVSKGGPKVSAENGASTSEDNA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTE_SALNS
Sequence: MDNFLALTLSGTTPRVRQGKSAGFRWRWLGHGLLELTPDAPVDRALILSAGIHGNETAPVEMLDKLLSALYSGSLTLTWRVLVVLGNPQALAAGIRYCHSDMNRMFGGRWQSFAESDETRRARELELSLETFFSSGQARVRWHLDLHTAIRGSHHLRFGVLPQRDRPWEADFLAWLGAAGLEALVFHQAPGGTFTHFSSEHFGALSCTLELGKALPFGQNDLTQFSVTSQALSALLSGVETSTSSSPPLRYRVVSQITRHSDKFALYMDAQTLNFTAFAKGTLLAEEGDKRVTVTHDVEYVLFPNPAVACGLRAGLMLERLP
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: ESXI_MYCTO
Sequence: MTINYQFGDVDAHGAMIRALAGLLEAEHQAIISDVLTASDFWGGAGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA
What are the official names of this protein?
ESAT-6-like protein EsxI.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-5 / type VII secretion system (T7SS).
Protein: SOX1_HUMAN
Sequence: MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVGVGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGLPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSRAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI
What is the function of this protein?
Transcriptional activator.  May function as a switch in neuronal development.  Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
What are the official names of this protein?
Transcription factor SOX-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: TDR12_HUMAN
Sequence: MLQLLVLKIEDPGCFWVIIKGCSPFLDHDVDYQKLNSAMNDFYNSTCQDIEIKPLTLEEGQVCVVYCEELKCWCRAIVKSITSSADQYLAECFLVDFAKNIPVKSKNIRVVVESFMQLPYRAKKFSLYCTKPVTLHIDFCRDSTDIVPAKKWDNAAIQYFQNLLKATTQVEARLCAVEEDTFEVYLYVTIKDEKVCVNDDLVAKNYACYMSPTKNKNLDYLEKPRLNIKSAPSFNKLNPALTLWPMFLQGKDVQGMEDSHGVNFPAQSLQHTWCKGIVGDLRPTATAQDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQFLNPDPLRADGISDLQQLQKLKGLQPPVVVLRNKIKPCLTIDSSPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCESNPLLYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKLPRGCDVIVTTPYSLLRLLACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNIEVEERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGNVQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFTCSVAETEIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDDCVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGVLEAKEDKKAGRPLCPYLKAFGFCKDKRICPDRHRINPETDLPRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNEYFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDAWALDDILVEFIDEGRTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKIVGKLHDAKVILALGNTVWIDPMVHITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKLREDAKIPACEESLSQTPPRVTGTSPAQDQDHPSEEQGGQGTPPAEDAACLQSPQPEDTGAEGGAESKTSSENQKPGGYLVFKRWLSSNR
What is the function of this protein?
Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity.  Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.  Involved in the secondary piRNAs metabolic process.  Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.
What are the official names of this protein?
Putative ATP-dependent RNA helicase TDRD12, ES cell-associated transcript 8 protein, Tudor domain-containing protein 12.
Protein: SESN1_CAEEL
Sequence: MHTTTKRRKAMDWLNFDPIPEVDRLFRFTCKHPTLHVHMTGSYGHMFVDISDLPASARHYLALMAASRHRCLSLMDHHRRKFLEKGGQQMWLLGIDWSYMKFRKLDYLNRMLCHRPWMIHWKNLAVLFARRTPDGGPAFFSVCSLHHAVGIMSMTHAMCTVICCIGLERRVDLTQDEIDFLNIDDLDYWEARMSAYFRKVPDRRPTEVEYLISELKKTEKGQTRPPAKMCAMTTETIESLISAPAATYSSNRKNYSPVLLLANIDENGEDIMEKEPPCNYPIYSHHRTFGYIDFRKRPEKDIPPFRVEEFGWDHVYNTMNEYTDTLTSRLDRMFDHIRTLTGNMPSGSSHASGDGEPPAAVNQNEIDTAAFREAIWNYTQGLYGVRVDDYDYSKINRVLDKGTKTFIKLAACYPHKLTTEFTRALPGFKDSEKIHVVMMVAMARFQASMFHYTRAVCNYNAMCLSKKGWRKPLD
What is the function of this protein?
May function as a negative feedback regulator of TOR function.
What are the official names of this protein?
Sestrin homolog.
What is the protein family that this protein belongs to?
Belongs to the sestrin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MURD_CLOB6
Sequence: MKSNFSKFKDFIKYKKVAVVGIGVSNRPLIKFLVKLGAKVTAFDKKHREKLGSISLELEEIGVDLVLGENYLDKLDGYDVIFKTPSMRIDRPEFVKAKESGAYITSEMEEFIKYCPAKVFGITGSDGKTTTTTLVYEMLKKEGYRTWVGGNIGTPLFANIEEMKEDHMVVLELSSFQLMTMDVSPEISLITNLSPNHLDVHKDFEEYVWAKKNIFKYQSSNNLLVLNKDDDLTNGMENEALGDVLKFSLVEKVYNGAYLSNNKLTMQGKEVCDSKDIKLKGRHNIANLLAAFCMVNKYVSIDSMKYVATNFSGVEHRCEFIREVNGVKYYNDSIASSPSRTLAGLNSFERPVILIAGGYDKKIPFKPLAEGGYDKIKILILMGDTKNKIKSAFEKVISHKKCEIEIVIVNSMEEAVKVADNMAEKGDIITLSPACASFDMYPNFEIRGNEFKNIVNSL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACY_LACDA
Sequence: MKKKLVSRLSYAAGAFGNDVFYATLSTYFIVFVTTHLFNAGDHKMIFIITNLITAIRIGEVLLDPLIGNAIDRTESRWGKFKPWVVGGGIISSLALLALFTDFGGINQSKPVVYLVIFGIVYLIMDIFYSFKDTGFWAMIPALSLDSREREKTSTFARVGSTIGANLVGVVITPIILFFSASKANPNGDKQGWFFFALIVAIVGILTSITVGLGTHEVKSALRESNEKTTLKQVFKVLGQNDQLLWLAFAYWFYGLGINTLNALQLYYFSYILGDARGYSLLYTINTFVGLISASFFPSLAKKFNRNRLFYACIAVMLLGIGVFSVASGSLALSLVGAEFFFIPQPLAFLVVLMIISDAVEYGQLKTGHRDEALTLSVRPLVDKLGGALSNWFVSLIALTAGMTTGATASTITAHGQMVFKLAMFALPAVMLLIAVSIFAKKVFLTEEKHAEIVDQLETQFGQSHAQKPAQAESFTLASPVSGQLMNLDMVDDPVFADKKLGDGFALVPADGKVYAPFAGTVRQLAKTRHSIVLENEHGVLVLIHLGLGTAKLNGTGFVSYVEEGSQVEAGQQILEFWDPAIKQAKLDDTVIVTVINSETFANSQMLLPIGHSVQALDDVFKLEGKN
What is the function of this protein?
Responsible for transport of beta-galactosides into the cell, with the concomitant uptake of protons (symport system), and also for transport of homologous and heterologous exchange of beta-galactosides.
What are the official names of this protein?
Lactose permease, Lactose transport protein, Lactose-proton symporter.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the sodium:galactoside symporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MNME_DINSH
Sequence: MDTIFALASAPGKSGVAVLRISGSRAFHAGRVLAGGLPDAQRTSLRKLRDSDGSVIDEALVLAFESPNSFTGEDCVEFQTHGSPAIIAALMNELSALPGLRLAQPGEFTRRALENNRMDLAQVEGLADLIEAETEAQRKQALRTFSGELGQKVELWRKDLVRAMALLEVTIDFADEEVPEDVYPEVQELLGRVSQNLAAESAGTHAAERIRHGFEVAILGAPNVGKSSLLNRLAGREAAITSSIAGTTRDVVEVRLDLDGLPVTVLDTAGLRETQDEIEQIGISRAMARAESADLRIILIEDGRLPSGLGVADDDILVQAKSDILPSSSEFAISSVTGRGIDRLVKAVSHRLSLRAASAGTATHVRHRLAISSAVESLDLAKTKISEGFPVELVIEDLRQALVDLESLIGRVGVEQVLDEIFANFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.