PharMolix/UniProtQA huggingface dataset:
Protein: SDRD_STAA8
Sequence: MLNRENKTAITRKGMVSNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAESTNKELNEATTSASDNQSSDKVDMQQLNQEDNTKNDNQKEMVSSQGNETTSNGNKLIEKESVQSTTGNKVEVSTAKSDEQASPKSTNEDLNTKQTISNQEALQPDLQENKSVVNVQPTNEENKKVDAKTESTTLNVKSDAIKSNDETLVDNNSNSNNENNADIILPKSTAPKRLNTRMRIAAVQPSSTEAKNVNDLITSNTTLTVVDADKNNKIVPAQDYLSLKSQITVDDKVKSGDYFTIKYSDTVQVYGLNPEDIKNIGDIKDPNNGETIATAKHDTANNLITYTFTDYVDRFNSVQMGINYSIYMDADTIPVSKNDVEFNVTIGNTTTKTTANIQYPDYVVNEKNSIGSAFTETVSHVGNKENPGYYKQTIYVNPSENSLTNAKLKVQAYHSSYPNNIGQINKDVTDIKIYQVPKGYTLNKGYDVNTKELTDVTNQYLQKITYGDNNSAVIDFGNADSAYVVMVNTKFQYTNSESPTLVQMATLSSTGNKSVSTGNALGFTNNQSGGAGQEVYKIGNYVWEDTNKNGVQELGEKGVGNVTVTVFDNNTNTKVGEAVTKEDGSYLIPNLPNGDYRVEFSNLPKGYEVTPSKQGNNEELDSNGLSSVITVNGKDNLSADLGIYKPKYNLGDYVWEDTNKNGIQDQDEKGISGVTVTLKDENGNVLKTVTTDADGKYKFTDLDNGNYKVEFTTPEGYTPTTVTSGSDIEKDSNGLTTTGVINGADNMTLDSGFYKTPKYNLGNYVWEDTNKDGKQDSTEKGISGVTVTLKNENGEVLQTTKTDKDGKYQFTGLENGTYKVEFETPSGYTPTQVGSGTDEGIDSNGTSTTGVIKDKDNDTIDSGFYKPTYNLGDYVWEDTNKNGVQDKDEKGISGVTVTLKDENDKVLKTVTTDENGKYQFTDLNNGTYKVEFETPSGYTPTSVTSGNDTEKDSNGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVKVTLLNEKGEVIGTTKTDENGKYCFDNLDSGKYKVIFEKPAGLTQTVTNTTEDDKDADGGEVDVTITDHDDFTLDNGYFEEDTSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNNATLFGGLFAALGSLLLFGRRKKQNK
What is the function of this protein?
Cell surface-associated calcium-binding protein which plays an important role in adhesion and pathogenesis (PubMed:26924733).  Mediates interactions with components of the extracellular matrix such as host DSG1 to promote bacterial adhesion to host cells (PubMed:26924733).  Contributes to the resistance to killing by innate immune components such as neutrophils present in blood and thus attenuates bacterial clearance (PubMed:27795358).
What are the official names of this protein?
Serine-aspartate repeat-containing protein D.
What is the protein family that this protein belongs to?
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Found in a ring-like distribution on the cell surface (PubMed:18800056). Colocalizes with ClfB (PubMed:18800056). Anchored to the cell wall by sortase A (Probable).
Protein: BOL1_BOMPE
Sequence: IKITTMLAKLGKVLAHV
What is the function of this protein?
Mast cell degranulating peptide.
What are the official names of this protein?
Bombolitin-1, Bombolitin I.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Bombolitin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GATZ_SHIB3
Sequence: MKTLIARHKAGEHIGICSVCSAHPLVIEAALAFDRNSTRKVLIEATSNQVNQFGGYTGMTPADFREFVFTIADKVGFARERIILGGDHLGPNCWQQENADAAMEKSVELVKAYVRAGFSKIHLDASMSCAGDPIPLAPETVAERAAVLCFAAESVATDCQREQLSYVIGTEVPVPGGEASAIQSVHITHVEDAANTLRTHQKAFIARGLTEALTRVIAIVVQPGVEFDHSNIIHYQPQEAQALAQWIENTRMVYEAHSTDYQTRTAYWELVRDHFAILKVGPALTFALREAIFALAQIEQELIAPENRSGCLAVIEEVMLDEPQYWKKYYRTGFNDSLLDIRYSLSDRIRYYWPHSRIKNSVETMMVNLEGVDIPLGMISQYLPKQFERIQSGELSAIPHQLIMDKIYDVLRAYRYGCAE
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of GatY.  When expressed alone, GatZ does not show any aldolase activity.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. GatZ subfamily.
Protein: Y630_MYCPN
Sequence: MQDKNVKIQGNLVRVHLSGSFLKFQAIYKVKKLYLQLLILSVIAFFWGLLGVVFVQFSGLYDIGIASISQGLARLADYLIRSNKVSVDADTIYNVIFWLSQILINIPLFVLGWYKISKKFTLLTLYFVVVSNVFGFAFSYIPGVENFFLFANLTELTKANGGLEQAINNQGVQLIFWEQTAEKQISLMFYALIWGFLQAVFYSVILIIDASSGGLDFLAFWYSEKKHKDIGGILFIVNTLSFLIGYTIGTYLTGSLLAQGFQEDRQKPFGVAFFLSPNLVFTIFMNIILGIFTSYFFPKYQFVKVEVYGKHMEQMRNYLLSSNQSFAVTMFEVEGGYSRQKNQVLVTNCLFTKTAELLEAVRRVDPDALFSITFIKKLDGYIYERKAPDKVVPPVKDPVKAQEN
What are the official names of this protein?
Uncharacterized protein MG432 homolog.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOA_STRR6
Sequence: MIEFEKPNITKIDENKDYGKFVIEPLERGYGTTLGNSLRRVLLASLPGAAVTSINIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKIIELDVEGPAEVTAGDILTDSDIEIVNPDHYLFTIGEGSSLKATMTVNSGRGYVPADENKKDNAPVGTLAVDSIYTPVTKVNYQVEPARVGSNDGFDKLTLEILTNGTIIPEDALGLSARILTEHLDLFTNLTEIAKSTEVMKEADTESDDRILDRTIEELDLSVRSYNCLKRAGINTVHDLTEKSEAEMMKVRNLGRKSLEEVKLKLIDLGLGLKDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: NU1M_SAPAP
Sequence: MFTINLLLLITPALIAMAFLTLMERKILGYMQLRKGPNTVGPYGVLQPIADAMKLFTKEPLLPSVSTTTLYMAAPTLALTIALLLWTPLPMPYSLINFNLGLLFVLATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYGVTLAIILLSTLLMSGSFNLHSLITTQEQSWLLLPSWPLTMMWFISTLAETNRAPFDLTEGESELISGFNIEYAAGSFALFFMAEYMNIIMMNALTTTIFTATPYNMLTTELYTMNFMTKTLLLTILFLWIRTAYPRFRYDQLMYLLWKKFLPLTLALCMWYISMPMLLSGIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PGGHG_HUMAN
Sequence: MEDAGEDPTTFAAHSLPSDPRLLATVTNAYLGTRVFHDTLHVSGVYNGAGGDTHRAMLPSPLNVRLEAPAGMGEQLTETFALDTNTGSFLHTLEGPRFRASQCIYAHRTLPHVLAFRVSIARLAPGSGPITLLLRSAFSPESPDLDLHQGPDFQGARYLYGHTLTPEQPGGPQQEVHMLWTPAPPDLTLGEGEEARTWDFLTAVGGSQAEAQACLTEALQLQARGALYTAHAQAWAQLWVECGLDVVGPLQLRQALRGSLYYLLSALPQPKAPGYICHGLSPGGLSNGSREECYWGHVFWDQDLWMFPSILMFHPEAARAILEYRIRTLDGALENAQNLGYQGAKFAWESADSGLEVCPEDIYGVQEVHVNGAVVLAFELYYHTTQDLQLFREAGGWDVVRAVAEFWCSRVEWSPREEKYHLRGVMSPDEYHSGVNNSVYTNVLVQNSLRFAAALAQDLGLPIPSQWLAVADKIKVPFDVEQNFHPEFDGYEPGEVVKQADVVLLGYPVPFSLSPDVRRKNLEIYEAVTSPQGPAMTWSMFAVGWMELKDAVRARGLLDRSFANMAEPFKVWTENADGSGAVNFLTGMGGFLQAVVFGCTGFRVTRAGVTFDPVCLSGISRVSVSGIFYQGNKLNFSFSEDSVTVEVTARAGPWAPHLEAELWPSQSRLSLLPGHKVSFPRSAGRIQMSPPKLPGSSSSEFPGRTFSDVRDPLQSPLWVTLGSSSPTESLTVDPASE
What is the function of this protein?
Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.
What are the official names of this protein?
Protein-glucosylgalactosylhydroxylysine glucosidase, Acid trehalase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 65 family.
Protein: PSB_METTP
Sequence: MVEAFKGTTTVGIVCDGGVVLASESRATMGSFIASRTAKKIYQIDDLVGLTTAGVVGDAQALVRMIQAEARLYRMQRGEPLTIKAITSLLSNILSARRYFPFLVQLVVGGVDKMGPKIFSLDALGGQIEEHDIVSTGSGSPIAYGVLESLYKPGLSIQDGSVLCVRAVHTAMKRDSASGNGIALVRITKDRYEEVPTSEVEEIVRSL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PsmB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MHPB_ECOSM
Sequence: MHAYLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISAFGNWRSEGRYYRPIPEWIAGFGSLSARTEN
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: IL34_MOUSE
Sequence: MPWGLAWLYCLGILLDVALGNENLEIWTLTQDKECDLTGYLRGKLQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLQKAHVSERELRYLWVLVSLNATESVMDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVRPKALLDNCFRVMELLYCSCCKQSPILKWQDCELPRLHPHSPGSLMQCTATNVYPLSRQTPTSLPGSPSSSHGSLP
What is the function of this protein?
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages.  Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes.  Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption.  Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).
What are the official names of this protein?
Interleukin-34, IL-34.
What is the protein family that this protein belongs to?
Belongs to the IL-34 family.
What are the subcellular locations of this protein?
Secreted.
Protein: BXRB_AGRCO
Sequence: MKFVLVLVSLALLVSLASVQGNNYCGRHLSETLAYMCPELEGASKRSGAMGAAAMYGTRGWRWAAMGGNRGKRGVVEECCYQSCTLDELLTYC
What are the official names of this protein?
Bombyxin-related peptide B, ABRP.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL31_SHEWM
Sequence: MKPGIHPEYAEITATCTCGNVIKVNSTAGKSLHLDVCGACHPFYTGTQKIVDTGGRIDKFNKRFGALGKK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RECF_ACIAD
Sequence: MQITRLNIERVRNLKAVALSGLQPFNIFYGANGSGKTSILEAVHLLATGRSFRTHMPKHYIQQNAQDAIIFAQSLSEKIGMQKLLSGEQLIKVNGDTVATQGQLAKLLPLQHLDPQSTDIIDHGAKPRRQLLDWLMFHVEPEFYFAWQYYSRALKQRNMLLKTKRQLSLAELEPWNKMLSEYGEMLHSQRLVTVERWKDFFQQDLAQLLPDLQIELEYSPGFHSEVGLWQDLLNYHNKDVERRYTEYGPHRADLRLKTALGDADDVLSRGQKKLLMMALKLSQIAMLHASNKETVVLLDDLTAELDSNAQRRLIERLSQLGSQVFITTLDHQAVTQHLDGLSISYQLYNVDHGQVHAV
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFGC1_SOYBN
Sequence: MAAESSLRVATPTLCNLNGSQRRPTTTTLSPLRFMGFRPRPSSHSLTSSSLSHFFGSTRIHSNSSSSYSSISRQHAPRRNFSVFAMSADDAKRSVPLKDYRNIGIMAHIDAGKTTTTERILYYTGRNYKIGEVHEGTATMDWMEQEQERGITITSAATTTFWNKHRINIIDTPGHVDFTLEVERALRVLDGAICLFDSVAGVEPQSETVWRQADKYGVPRICFVNKMDRLGANFYRTRDMIVTNLGAKPLVIQLPIGSEDNFKGVIDLVRNKAIVWSGEELGAKFDIVDIPEDLQEQAQDYRAQMIENIVEFDDQAMENYLEGIEPDEETIKKLIRKGTISASFVPVMCGSAFKNKGVQPLLDAVVDYLPSPLDLPAMKGSDPENPEATIERLASDDEPFAGLAFKIMSDPFVGSLTFVRVYAGKLGAGSYVLNANKGKKERIGRLLEMHANSRDDVKVALAGDIIALAGLKDTITGETLCDPDNPIVLERMDFPDPVIKVAIEPKTKADVDKMATGLIKLAQEDPSFHFSRDEEINQTVIEGMGELHLEIIVDRLKREFKVEANVGAPQVNYRESISKISEVKYVHKKQSGGQGQFADITVRFEPMDPGSGYEFKSEIKGGAVPREYIPGVMKGLEECMSNGVLAGFPVVDVRAVLTDGSYHDVDSSVLAFQLAARGAFREGIRKAGPRMLEPIMKVEVVTPEEHLGDVIGDLNSRRGQINSFGDKPGGLKVVDSLVPLAEMFQYVSTLRGMTKGRASYTMQLAMFDVVPQHIQNQLATKEQEVAA
What is the function of this protein?
Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids.  Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G-1, chloroplastic, cEF-G 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PYRE_ECO81
Sequence: MKPYQRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQGRVMLVDDVITAGTAIRESMEIIQANGATLAGVLISLDRQERGRGEISAIQEVERDYNCKVISIITLKDLIAYLEEKPEMAEHLAAVKAYREEFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: RM05_ARATH
Sequence: MFPLNFHYEDVLRQDLLLKLNYANVMEVPGLCEIRVVPKAPYNFIIKNGKLAMEIPCGQKFIQTQRGSTGKSFRSNPFLGSNKDKGYVSDLARQSTLRGHGMSNFLVRILTVMSLLDFPVEIRKNSIQFSMETEFCEFSPELEDHFEIFEHIRGFNVTIITSANTQDETLLLWSGFLQKDEGETQ
What are the official names of this protein?
60S ribosomal protein L5, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RECO_DEHMB
Sequence: MTKPHDFKTKAIIVRKTKCGEADRILSLLTPDLGLIQGFAKSVRKTTSKLSGHLELLCYSEVSLARGKAIDTITGSQTIQSFLNIRNSLQLSAMAFYACELAYHFSPEEAANPALFQLLLSTLEELDNGSQPELCLKYFEINLLASSGYKPELRECANCHKKLQATINYYSPESGGVICPNCRNTQIGMPVSVNTVKVLRYIQENSFSSICRLKINREILSELELAIRANIRFVLEKEPKALFWLDSLRLADL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RIFG_AMYMS
Sequence: MRTTIPVRLAERSYDVLVGPGVRAALPEVVRRLGARRAVVVSARPADWVPGTGVETLLLQARDGEPTKRLSTVEELCGEFARFGLTRSDVVVSCGGGTTTDVVGLAAALYHRGVAVVHLPTSLLAQVDASVGGKTAVNLPAGKNLVGAYWQPSAVLCDTDYLTTLPRREVLNGLGEIARCHFIGAPDLRGRSRPEQIAASVTLKAGIVAQDERDTGPRHLLNYGHTLGHALEIATGFALRHGEAVAIGTVFAGRLAGALGRLDQSGVDEHLAVVRHYGLPAALPADVDPAVLVRQMYRDKKAITGLAFVLAGPRGAELVSDVPAPVVTDVLDRMPRDSLENLVGTTEAAAP
What is the function of this protein?
May catalyze the conversion of 3,4-dideoxy-4-amino-D-arabino-heptulosonate 7-phosphate (aDAHP) to 5-deoxy-5-amino-3-dehydroquinate (aDHQ).  Probably involved in the formation of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of rifamycin and related ansamycins.
What are the official names of this protein?
Putative aminodehydroquinate synthase, aDHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. aDHQS family.
Protein: INSD3_ECOLI
Sequence: MDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsD for insertion element IS2F.
Protein: ATG8_PHYIN
Sequence: MSSFKKEHPFEKRQAEAQRIRSKYPDRIPVICEKADRSDIPDIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFINNVLPPTAALMSNIYEEQKDVDGFLYITYSGENTFGQ
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier ATG8.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: TRMY_METLZ
Sequence: MLRFAVIGHKAVSTPDFSLNDMPGGAGRMDVLCRCINASFFLSHDLRRDTECFLILKGGEQADPANTVTLRFSGEKIKSLNPDERSAGALIKKALVTIPEEEYQRAAPGISIRKSGLAKLLEEHPFAVLDENGEDIRTAETLPENFILSDHQNFTEEEMELIKDLPKYSVGPRVLHADHTIIIILNEFDRRGEQA
What is the function of this protein?
Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.
What are the official names of this protein?
tRNA (pseudouridine(54)-N(1))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. TrmY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCP1_CANLF
Sequence: MLRAPGSDAPPTLSVRIAAAAGAACLADMITFPLDTAKVRLQIQGEGQGQPPRAPRYRGVLGTVATLARTEGLQKLYSGLPAGLQRQVGFASLRIGLYDSVREWLSPGQGAAASLGSRISAGVMTGGAAVFIGQPTEVVKVRLQAQSHLHGRKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRNVIINCTELVTYDLMKEALVKNHLLADDLPCHFLSALVAGFCTTVLSSPVDVVKTRFVNSVPEQYTSVPNCAMTMLTKEGPLAFFKGFVPSFLRLGSWNVIMFVCFEQLKRELMKSGRTVDCAT
What is the function of this protein?
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance.  Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane.  However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs.  Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP.  Regulates the production of reactive oxygen species/ROS by mitochondria.
What are the official names of this protein?
Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GATB_TREPA
Sequence: MSDLQTGTVPSIAGATDDTHAAPFFYEVIIGCEIHCQLLTKTKAFCACANRSGGMPNSRVCPVCLGLPGALPVVSEEYVRLGVRAGLALGCTIQLWSAFDRKHYFYPDLPKGYQITQYDAPLCTDGAVDVQGVDMPVQRRVRIERIHLEEDAGKSLHAADAYSYIDFNRCGVPLIEIVSRPDLRSAEEAACFMQTIREILTFIEVTDGNLEEGALRCDANVNVRILYKGQEHHTPISEIKNMNSYRMVRDACTYEVQRQLQEFWQKGPASKEEMQRKRTMGWDPVEGVTLLQRTKHSLRDYRFMRDPDLPDLHLTPAYVQHLSYTVGELPAARRARFKLDLGLSAFAAQTLTGSRMLADWFEKAAHASKNARRVANWILSEVLAVVNEKNICIAELNLSPEAIAELMDAVEDQRITGKQAKDIFAQMLATGARAQDIISAQGLAQLSDEEEIATLVQTVFQEHPKALRDWQHGKTNVAAWLMGQVMKRSRGRAHPARVATLVHQALSQL
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: ARLY_DEHMC
Sequence: MSHIRSRFSKPADELVVRYTTSLPFDWRLYKEDIKCSTAHARMLSKQGIISAEDSQSIINGLNTILTEIETGSFVFKPETEDIHMAIEGRLFELIGEAAGRLHTARSRNDQVATDVHLFVKNACDETINKIRTLQGALLEQAEAHPQTALPGYTHMQIAQPVLLPHHLLAYFEMLERDCGRFTDARKRADVMPLGSGALAGVPYPLDREMVAKELGFSAISQNSLDAVSERDFILEYLSDAAICQMHLSRLSEEMVIWSSAEYAFVELDDAYTTGSSIMPQKKNPDVAELCRGKTGRVYGSLNTMLTVMKGLPLSYNRDLQEDKEPLFDCVDTLGDSLEVFAGMIKTAKFKPERMLRALEKGYVLATDIADYLVGKGESFRNSHGIVARLVSYAVAQNKTFGELSLAEYRQFSNLFEKDIYAVDIKSALNARNLPGGTAPKQIAQAIARAKKILAEAGVKN
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNFA_CANLF
Sequence: MSTESMIRDVELAEEPLPKKAGGPPGSRRCFCLSLFSFLLVAGATTLFCLLHFGVIGPQREELPNGLQLISPLAQTVKSSSRTPSDKPVAHVVANPEAEGQLQWLSRRANALLANGVELTDNQLIVPSDGLYLIYSQVLFKGQGCPSTHVLLTHTISRFAVSYQTKVNLLSAIKSPCQRETPEGTEAKPWYEPIYLGGVFQLEKGDRLSAEINLPNYLDFAESGQVYFGIIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.
Protein: HDGF_BOVIN
Sequence: MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEATEGDGDKKGNAEGSSDEEGKLVIDEPTKEKNEKGALKRRAGDLLEDSPKRPKEAEDLEGEEKEGATLEGERPLPVEAEKNSTPSEPGSGRGPPQEEEEEEEEEEAAKEDAEAPGLRDHESL
What is the function of this protein?
Acts as a transcriptional repressor (By similarity).  Has mitogenic activity for fibroblasts (By similarity).  Heparin-binding protein (By similarity).
What are the official names of this protein?
Hepatoma-derived growth factor, HDGF.
What is the protein family that this protein belongs to?
Belongs to the HDGF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted, extracellular exosome. Note=Secreted by exosomes and is located inside the exosome (By similarity). May also be secreted as free protein via an as yet unknown pathway (By similarity).
Protein: RL1_GLAP5
Sequence: MAKLTKKMKAIKAGVDSTKAYEINEAIAVLKQFATAKFVESVDVAVNLGIDPRKSDQNVRGATVLPHGTGRTARVAVFTQGANAEAAKAAGADLVGMEDLAEQVKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKSGQIRYRNDKNGIIHTTIGKADFSPEQLKENLQALLAALVKAKPTTAKGIFIKKVSISTTMGAGVAVDQASL
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.