PharMolix/UniProtQA huggingface dataset:
Protein: TSAD_BRUAB
Sequence: MRVLGIETSCDETAAAIVERDDMGEGRILSNVVLSQIAEHEPYGGVVPEIAARAHVEALDRLVDRALNDAGLKLYEVDAVAATAGPGLIGGLIVGLMTAKALAMAAQKPFYAVNHLEGHALTARLTDGLPFPYLLLLVSGGHTQMVLVRGIGDYERLGTTIDDALGEAFDKTAKLLGLPYPGGPTVERMALQGDQKRFALPRPLKGEARLDFSFSGLKTAVRQTATELVPLTDQDVTDICASFQAAVADTLSDRVGRSLERFKTEFPDCATPSLVVAGGVAANKTLRAALENLCTRHGFAFIAPPLNLCTDNAAMIAWAGAERAATQAPDSLDIAPRSRWPLDEKSAPVFGTGRRGAKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAEL_DROGR
Sequence: MAPKKTNGFMIFVNEWRKGRNISIAQAVSHCGDIWKNMSAQQKGPYNGFAKDANVSARAKVEPLDCHGRPLSAVERENCEAAEREMNMKRNIERIVLEGKAQHDLENTKFIFAAFNYFTKAIGNDIYMPAEFAACKFSLRSGRGPVYSSHINPGQLIFGQASDAQHHTSTTHQLPLPPKAMGESNMGSLYVNIVKYLRDCQGAGNPLVVFTTAELMPVVSGCFRYLQSDSDEVGEQIHVYDILYLFYVLKKEVMDIADLPHANINKCITDNFFFNDFFEYYSNIACQFHEDNDRGKYCTHSMVSRWCYTFCDYMCGDLAIKPLAGKHMPPVQEQKFCVTNPDKSMCGNTSYNSVSSWHSDVKQEPDSDYTPEDHSVFSANLTATEEFPSLSGRRPKPTHRHPPPQKGAWNVPAAKRSARDFDDAFNMTR
What is the function of this protein?
Involved both in the piRNA and miRNA metabolic processes.  As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons.  As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam).  Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
What are the official names of this protein?
Protein maelstrom.
What is the protein family that this protein belongs to?
Belongs to the maelstrom family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein: E1B9_ADE07
Sequence: MDPPNSLQQGIRFGFHSSSFVENMEGSQDEDNLRLLASAASGSSRDTETPTDHASGSAGGAAGGQSESRPGPSGGGVADLFPELRRLP
What are the official names of this protein?
Early E1B 9 kDa protein.
Protein: GON1_CHEPR
Sequence: QHWSDYFKPG
What is the function of this protein?
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
What are the official names of this protein?
Gonadoliberin-1, Gonadoliberin I, Gonadotropin-releasing hormone I, GnRH-I, Luliberin I.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: RBL_DICCR
Sequence: MSPQTETKASVGFKAGVKEYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEKAGAAVAESSTGTWTTVWTDGFTSLDRYKGRCYHIEPVAGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFCFCAEALYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHXHRAMHAVIDRQKNHGMPFRVLAKALRMSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLASEGNEIIREAS
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CASC_ECOLI
Sequence: MSNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKSGYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKSVDEAEKISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIRVNLQQGVDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFTAVDDLQEQGSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHVVHMLATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQPSIQAFNQYWDRVANGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSWVRNNGEA
What is the function of this protein?
A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity.  Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target.  This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand.  Cas3 is recruited to Cascade, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization.  CasCDE alone is also able to form R-loops.
What are the official names of this protein?
CRISPR system Cascade subunit CasC.
Protein: NUOH_ECO45
Sequence: MSWISPELIEILLTVLKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWIPKFSDRVIFTLAPMIAFTSLLLAFAIVPVSPGWVVADLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNMTDIVNSQAHVWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGEYIGIVTISALMVTLFFGGWQGPLLPPFIWFALKTAFFMMMFILIRASLPRPRYDQVMSFGWKICLPLTLINLLVTAAVILWQAQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: 044L_IIV3
Sequence: MPLSVFAEEFAEKSVKRYIGQGLWLPCNLSDYYYYQEFHDEGGYGSIHRVMDKATGNEVIMKHSYKLDFSPGILPEWWSKFGSLTDDLRERVVSNHQLRVSREAQILVQASTVLPEMKLHDYFDDGESFILIMDYGGRSLENIASSHKKKITNLVRYRAYKGNWFYKNWLKQVVDYMIKIYHKIKILYDIGIYHNDLKPENVLVDGDHITIIDFGVADFVPDENERKTWSCYDFRGTIDYIPPEVGTTGSFDPWHQTVWCFGVMLYFLSFMEYPFHIDNQFLEYALEGEKLDKLPEPFAQLIRECLSVDPDKRPLTSLLDRLTELHHHLQTIDVW
What are the official names of this protein?
Putative serine/threonine-protein kinase 040L.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: NUSB_HELMI
Sequence: MSRRQGRETALQTLFMADVGRMEPAYALQYASEEFGISEAAAAFARELVEGAVANRETIDGNIRRLAKEWNLERMPHVDRNLLRVAIFEMLFREDIPLNAAINEAIELAKIYANEESAKFVNGILGQLARELREARGEKTSAQEGAPAAVTNRVTTPAPESTPVPDPDATPATTPVTTTVISETAANRETRSMAEEETQPPGVNEV
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: NRDR_COXB2
Sequence: MYCPFCNAEDTKVIDSRLVEEGTQVRRRRECLKCQERFTTFETAELNLPRIIKRDGRRSAFDEEKLRAGLLKALEKRPISTEQIETAVQRIIHKLRARGECEVSSQWLGELVMDELRALDEVAYVRFASVYRSFQDINAFRDEIRRLQKQQKKSHDK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: AROC_LISMH
Sequence: MRYLTAGESHGPGLTTIIEGLPAGMPLLAEDVNKELKRRQGGHGRGARMRIEKDQVQITAGIRHGKTLGAPVAMFVENKDWKHWETVMSIEPVPEKNEKSRRVSRPRPGHADLVGGMKYGHNDMRNVLERSSARETTVRVAAGAVAKKLLHELGIEVAGHVLEIGGTRANLTRDYAVREIQETSEASPVRCLDGVAAEEMMQKIDDAKKNGDTIGGIVEVVVGGVPAGLGSYVQWDKKLDAKIARAIVSINAFKGAEFGVGFEAARKPGSEVMDEILWSKEDGYTRRTNNLGGFEGGMTNGMPIVVRGVMKPIPTLYKPLQSVDIDSKETFNASVERSDSCAVPAASVVAEAVVAWEVAVAVLEKFDGDRFDTLKKHVEEHRNLTKEF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RS8_NEOSM
Sequence: MPNSLIADAVARIRNGQMARLREVTIYHSRVLVEIAALLKEEGYIVGYEVIEIRPSVKRIIIRLKYYCGQPVISKLKLFSRPGKRIYSRACEIPKFYGGLGISVLSTSKGILPSYKAVSSNCGGELLFGVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: Y3506_METJA
Sequence: MSVELRTLFRLIAVLEHSEEFKKVLFACERHFESGYCKCGPMEMCNIALAEAMKEDPTLVLRKWRRVFTYLEEVGIIKTRKLEAPANRPRRYIKLSENWMEALRTAIDKEYEKLIR
What are the official names of this protein?
Uncharacterized protein MJECL06.
Protein: TCEB1_TULGE
Sequence: MSIVSFCSSLPAGPHGFKHGRGTRDMVHMPCIVRRTARSPAQACRLLRWNKYHCAAVPTNSSLSPSPTPLDVEIELDLEPFLIKYKSGRIERLGRFGDRTDYVEASLDPATEVTSRDAITDTGVPVRIYLPKVDDSPPNSLRVLVYFHGGAFLVEDSASPPYHNYLNNLASKANILIVSVNYRLAPEYPLPVAYDDCMEALNWVNKHSDGTGQEDWINKHGDFDHLFISGDSAGGNITHNIAMSTDAPKNIEGIALVHPYFFGKVALETELQDPTNLLLHRKLWSFITPESEGLDDPRVNPLGPTAPSLEKIKCKRAVVFVAGEDFHSERGRKYSEKLKSEFKGEVPLLCNHDGVGHVYHLSVDATEEEIESAAAWKMMTDLLKFYKDNDVVLEGSIVESLKAKTTEGIKKMKEIEKGMSERMMEQLVAFYNGKPVPYSS
What is the function of this protein?
Lactone-forming carboxylesterase, specifically catalyzing intramolecular transesterification, but not hydrolysis.  Involved in the biosynthesis of tulipalins, defensive chemicals that show antimicrobial activities against a broad range of strains of bacteria and fungi.  Substrates are 6-tuliposide B > 6-tuliposide A.
What are the official names of this protein?
Tuliposide B-converting enzyme 1, amyloplastic, TgTCEB1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Plastid. Plastid, amyloplast.
Protein: ENGB_LACP3
Sequence: MDVHDVKLTISAVAAAQYPEDGHPEIAFLGRSNVGKSSLINKLIQRKAMARTSGVPGKTQTLNFYDLDSRLFFVDVPGYGYAKVSKTARAKFAAMIETYLTTRQPLRGVVLLVDSRHEPTADDISMYQYLKYYQLRTLVVATKIDKTPKSKRLHVAKQIKQRLDLNQTDDVILFSATTGEGYEAVWSWLEQTAGLEGR
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: ISPE_BURL3
Sequence: MTDSTRSLRNCLAPAKLNLFLHITGRRPNGYHDLQSVFQLLNWGDTLHFTLRDDGRVARVTDVPGVPEESDLVVRAANLLKAHTGTAHGVDIEIDKCLPMGAGLGGGSSDAATTLLALNRLWQLDLPRAELQSLAVKLGADVPFFIFGKNAFAEGIGEELAEVQLPTRWFLVVTPRVHVPTAEIFSDELLTRDSKRVTITDFLAQQNSDAGWPDSFGRNDMQQVVTSKYAEVAQVVKWLYDVTPARMTGSGASVFAAFRSKHEAEAAQAKLPTGWNGAVAESLNEHPLFAFAS
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RS9_CUPMC
Sequence: MIGNWNYGTGRRKSAVARVFIKSGKGDIIVNGKPIKEYFARETSLMIVRQPLELTAHAETFDIKVNVTGGGETGQAGAVRHGITRALIDYDATLKPTLSKAGYVTRDAREVERKKVGLHKARRRKQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: NRDR_LEVBA
Sequence: MQCPHCHHNGSRVVDSRPTDDGRVIRRRRECESCGFRFTTFERVEVTPLLVIKKNGTREEFNREKVLRGIIRSAEKRPVGMDVMTQIVDEVENKIRALGVSEISSQLIGEYVMNRLVDVDEIAYIRFASVYRQFKDTGVFFNELKDMLDKDKLKAKKETNGKSEAK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PHNC1_HALMA
Sequence: MKSKYTARPEGKQSGQGLVFDSVTKRFGGKVAVRDVSLKLEAGERVAVIGPSGAGKTTLLRLAAGALQPDVGTVRFDGSSSTGSTATLAYQGETLVDRRTALSNVLTGRLGALSWLRGFIEPLLPQHPEPALERLDAVGLVGRADVPVKSLSAGERQRVAFARALMQDAEVVLADEPTANLDPSSRRNVIDVLDAALDGELLVTVLHEVDLALEHFDRIVGMADGRVRFDTPARAVTDDQLDALFAAGASTPGTDAERTGTEKESDIPVPWYV
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MTD1_CAEEL
Sequence: MRSSLLLLVFFLSIGWARYCVHNEKSWCQGHNIWGWCFHNKSSGVFNCDDNAFCVSQEQLKNKKSSGCFLRDNSSICCCNDADGCNLGFIGVQPKYAHGQQCTNSMEVPNEDIRQFRPCDDPFCYSVLTAEDDGGPTTVTRGCHSRKMVMHHMSKNEDDKYQNNTKWRETKQIAEMPSCAEILKDQPKVNGTTSMCVDFTYDQEAEDGEEVDEPIKMKGRLCCCAGSNKCNEHAMWADEGISLTEMLEEIEARKVPVDSSAPVNIILSIAFSIFLIHF
What is the function of this protein?
Plays a role in mechanosensory transduction (touch sensitivity).
What are the official names of this protein?
Protein mtd-1, Mec three-dependent expression protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein; Extracellular side.
Protein: VATA_ACET2
Sequence: MSQGTIVKVSGPLVIAEGMRDANMFDVVRVSEHRLIGEIIEMHGDRASIQVYEETAGLGPGEPVVSTGAPLSVELGPGLIENIFDGIQRPLVKMREMVGSNITRGIDVTALDRSKKWDFQPTVKKGDKVTAGDVIGKVQETSIVEHRIMVPYGVQGTIEEIKSGSFTVEETVAKVRTENNELVDICMMQKWPVRIGRPYREKLPPNAPLVTGQRVIDTLFPLAKGGVAAVPGPFGSGKTVVQHQLAKWADADIVVYIGCGERGNEMTDVLKEFPELKDPKTGESLMKRTVLIANTSDMPVAAREASIYTGMTIAEYFRDMGYSVALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLGSRLAQFYERAGRVVCLGSDGREGALTAIGAVSPPGGDLSEPVTQATLRIIKVFWGLDSSLAYRRHFPAINWLQSYSLYLDIIGKWISENISRDWETLRSDTMRILQEEAELEEIVRLVGVDALSPSDRLTLEAAKSIREDYLHQNAFHEVDTYTSLNKQYRMLKLILGFYYSGKKALEAGVSIKELFELPVREKIGRAKYTPEDQVNSHFNEIEKELNEQIEALIAKEVQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: Y1320_DICDI
Sequence: MFSSIMFKKKPKQNLNENEITSQSTTTTSTLSDSKPSEKKIKDNKNDKFKINENDTIVEIEWESDIQQKYDLIALYDNDTNVIDDYIWHWKINDEYTYNNNNTNIIRDPNKNYYIKYWRIDDNNNGINHHHHYNHHHHINNHHHNHIKTNHHSLPPNLHLSPLHNNNHHRHHSHQFPKVSINNVYKQIHNYKLKNHFIRQQFQNNSTTNQDTIKIKLSHFEERNLLKSVDYSGEMFKQYSNWMTNNWERIKDKMVRDLVLPGSHDAATYGIKSSSLRVPGDKVPSFIPNSIVSKWSKTQSGNIFKQLTMGYRYFDLRVAPYPVTGKLYIYHAMFSVPVSEVLDDIVKFIKNTNYYQQPNSSNNNDEKQQLQQQQQLFKKEIILLHWNHLGYLSIEQHQELQLMIKSKLDGMLANRQLGNNVKVRELEFTPIINIYDDNGLKKRIINDDGKKSKQPFDSIQNEPLFWYSNKSLVSNYDSNQFHTSKDVISFLSREVTYNHKDRFWVAQCILTIDSKKLLHITTNSLLDWNHSEFPKFLKFFENLEEKKVPTNIIMTDFCTHYPITDYAIRRNINE
What are the official names of this protein?
PI-PLC X domain-containing protein DDB_G0269228.
Protein: LEU3_FRACC
Sequence: MRLAVIGGDGIGPEVVAEGLRVLRAVHPKVDTTEYDLGARRWHETGETLPDSVLEELRGHDAILLGAVGDPGVPSGVLERGLLLRLRFEFDHHVNLRPVRLYPGVRSPLAGDPAIDMIVVREGTEGPYAGAGGVLRKGTPHEVATEESLNTRYGVERVVRDAFRRADRRERRHLTLVHKNNVLTKAGDLWSRTVAEVAPEFPDVRVDYQHVDAASMFFVTDPGRFDVVVTDNMFGDILTDIGAAITGGIGLAASGNLDPSGVHPSMFEPVHGSAPDIAGRQLADPTATVASVAMLLDHLGHAEEAAKVEAAVASSLADRAAAGAAQPSTRERGEDLAARAAG
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROCA_BACCR
Sequence: MVVAYKHEPFTDFSVEANKLAFEEGLKKVESYLGQDYPLIIGGEKITTEDKIVSVNPANKEELVGRVSKASRELAEKAMQVADETFQTWRKSKPEMRADILFRAAAIVRRRKHEFSAILVKEAGKPWNEADADTAEAIDFMEYYGRQMLKLKDGIPVESRPIEYNRFSYIPLGVGVIISPWNFPFAIMAGMTTAALVSGNTVLLKPASTTPVVAAKFMEVLEEAGLPAGVVNFVPGNGSEVGDYLVDHPRTRFVSFTGSRDVGIRIYERAAKVNPGQIWLKRVIAEMGGKDTIVVDKEADLELAAKSIVASAFGFSGQKCSACSRAVIHEDVYDHVLNRAVELTKELTVANPAVLGTNMGPVNDQAAFDKVMSYVAIGKEEGRILAGGEGDDSKGWFIQPTIVADVAEDARLMKEEIFGPVVAFCKAKDFDHALAIANNTEYGLTGAVITNNRDHIEKAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLALHMQAKTTSETL
What are the official names of this protein?
1-pyrroline-5-carboxylate dehydrogenase, P5C dehydrogenase, L-glutamate gamma-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. RocA subfamily.
Protein: F184B_HUMAN
Sequence: MASALNSKINPPGTCQGSKADGGAGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHPGYLTPSMKKKKVEDVPSRVVSVPNLASYAKNFLSGDLSSRINAPPITTSPSLDPSPSCGRTYKPNQSTDAKTATRTPDGETAQAKEVQQKQGSPHQEWFTKYFSF
What are the official names of this protein?
Protein FAM184B.
What is the protein family that this protein belongs to?
Belongs to the FAM184 family.
Protein: INVO_AOTTR
Sequence: MSQQHTLPVTLPPALSQELLDTVPPPVNTQQEQRKQPAALPPPCQEVPVELPVEGPSKHEEKHMTIVKGAPEQECEQQQQPQEQKLQQQHWEQDEEHQKAENPEQQLKQEKAQREKQQLQGQLEEEKKLLDQQPDHELAKSDEQLGTKKEQLLEFPEQQEGQLKCLEQQEGHLELPEQQEGQLKCLEQQEGHQELPEQQEGQLKHLEQQEGQLKHLEQQEGQVKHLEQQEKQSELPEQQRGQPKYLEQQEGQLKHLEEQKGQLKHLEHQEGQLELPEQVGQPKHLEQLEKQLEHPEQQEGQLKQLEEQEGQVKHLEQQEEQLKHLEQQEGQPKHPEQLEKQLEHPEQQEGQLKQLEEQEGQVKHLEQQEEQLKHLEQQEGQPKHLEQLEKQLEHLEQQEGQLKHLEQREEQLELPEQQVGQSKHLEQEEKQLEHPEQQEGQLKHLGKQEAQLELPEQVGQPKHLEQQEKQLEHPEQQEGQLKPQEQQEGQLKGLEQQERQLEQPVFAPAPGQVQGIQQALPPKGEVLLPVEQQQQKQEVQWQHK
What is the function of this protein?
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
What are the official names of this protein?
Involucrin.
What is the protein family that this protein belongs to?
Belongs to the involucrin family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
Protein: GSID_ECOK1
Sequence: MRLFNWRRQAVLNAMPLVKPDQVRTPWHEFWRRFRRQHMAMTAALFVILLIVVAIFARWIAPYDAENYFDYDNLNNGPSLQHWFGVDSLGRDIFSRVLVGAQISLAAGVFAVFIGAAIGTLLGLLAGYYEGWWDRLSMRICDVLFAFPGILLAIAVVAVLGSGIANVIIAVAIFSIPAFARLVRGNTLVLKQQTFIESARSIGASDMTILLRHILPGTVSSIVVFFTMRIGTSIISAASLSFLGLGAQPPTPEWGAMLNEARADMVIAPHVAVFPALAIFLTVLAFNLLGDGLRDALDPKIKG
What is the function of this protein?
Part of the ABC transporter complex GsiABCD involved in glutathione import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Glutathione transport system permease protein GsiD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GET3_PARBD
Sequence: MSSAAMVKAEDSLEPTLQNLLDQKTLRWVFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLIDGFTNLSAMEIDPNGSIQDLLAAGGGQGDDSMGGLGIGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIIFDTAPTGHTLRFLQFPTVLEKALAKLAQLSTQFGPMLNSILGGRGGLPGGQNLDEILSKMESLRETIAEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYHIDTHCIVVNQLLFPGKDSSCEQCKARRKMQKKYLNEIEELYEDFNVVRMPMLVEEVRGKEKLEKFSDMLIHPYVPPQE
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: METXS_ALKEH
Sequence: MPKHLPADSVGIVEQHSLHFDEPLPLDCGRSLPAYDLVYETYGELNAERSNAILICHALSGSHHAAGYHSEEDRKPGWWEACVGPGKPIDTDRFYVVCCNNLGGCHGSTGPSSINPETHRPYGPDFPLVTVRDWVHSQARLADALGIERWAAVVGGSLGGMQAIQWAIDYPDRLGHVVAIAVAPRLSAQNIGFNEVARQAILTDPEFHGGRYYEHHTVPRRGLALARMLGHITYLSDDAMRDKFGRDLRADGGRYKFNFDVEFEVESYLRYQGRSFVDRFDANTYLLMTKVLDYFDPAAEYDHDLSAALAHVQARFLLISFSSDWRFPPERSREIVRALEDNQKPISYLEVETSQGHDAFLKPIPVYTEAFRAYMQGIAREVGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.