PharMolix/UniProtQA huggingface dataset:
Protein: LORF2_HUMAN
Sequence: MTGSNSHITILTLNVNGLNSPIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKIKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSILDRSTRQKVNKDTQELNSALHQTDLIDIYRTLHPKSTEYTFFSAPHHTYSKIDHIVGSKALLSKCKRTEIITNYLSDHSAIKLELRIKNLTQSRSTTWKLNNLLLNDYWVHNEMKAEIKMFFETNENKDTTYQNLWDAFKAVCRGKFIALNAYKRKQERSKIDTLTSQLKELEKQEQTHSKASRRQEITKIRAELKEIETQKTLQKINESRSWFFERINKIDRPLARLIKKKREKNQIDTIKNDKGDITTDPTEIQTTIREYYKHLYANKLENLEEMDTFLDTYTLPRLNQEEVESLNRPITGSEIVAIINSLPTKKSPGPDGFTAEFYQRYKEELVPFLLKLFQSIEKEGILPNSFYEASIILIPKPGRDTTKKENFRPISLMNIDAKILNKILANRIQQHIKKLIHHDQVGFIPGMQGWFNIRKSINVIQHINRAKDKNHVIISIDAEKAFDKIQQPFMLKTLNKLGIDGMYLKIIRAIYDKPTANIILNGQKLEAFPLKTGTRQGCPLSPLLFNIVLEVLARAIRQEKEIKGIQLGKEEVKLSLFADDMIVYLENPIVSAQNLLKLISNFSKVSGYKINVQKSQAFLYNNNRQTESQIMGELPFTIASKRIKYLGIQLTRDVKDLFKENYKPLLKEIKEDTNKWKNIPCSWVGRINIVKMAILPKVIYRFNAIPIKLPMTFFTELEKTTLKFIWNQKRARIAKSILSQKNKAGGITLPDFKLYYKATVTKTAWYWYQNRDIDQWNRTEPSEIMPHIYNYLIFDKPEKNKQWGKDSLLNKWCWENWLAICRKLKLDPFLTPYTKINSRWIKDLNVKPKTIKTLEENLGITIQDIGVGKDFMSKTPKAMATKDKIDKWDLIKLKSFCTAKETTIRVNRQPTTWEKIFATYSSDKGLISRIYNELKQIYKKKTNNPIKKWAKDMNRHFSKEDIYAAKKHMKKCSSSLAIREMQIKTTMRYHLTPVRMAIIKKSGNNRCWRGCGEIGTLVHCWWDCKLVQPLWKSVWRFLRDLELEIPFDPAIPLLGIYPKDYKSCCYKDTCTRMFIAALFTIAKTWNQPNCPTMIDWIKKMWHIYTMEYYAAIKNDEFISFVGTWMKLETIILSKLSQEQKTKHRIFSLIGGN
What is the function of this protein?
Has reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition (PubMed:9140393, PubMed:7516468).  Also has endonuclease activity that allows the introduction of nicks in the chromosomal target DNA (PubMed:8945517, PubMed:17626046, PubMed:34554261).  Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome (PubMed:8945517).  Conformational properties of the target DNA sequence rather than specific nucleotides are key determinants of the ORF2p capacity for sequence-specific DNA recognition (PubMed:17626046, PubMed:34554261).  Unlike related endonucleases, does not bend the DNA helix but causes compression near the cleavage site (PubMed:34554261).
What are the official names of this protein?
LINE-1 retrotransposable element ORF2 protein, ORF2p.
Protein: CML1_ARATH
Sequence: MPIFQWLKRCLCGDTNITIDQAIALVDEEIANLRKLERGYQTNIRNAENARDQTNVQIERDSFNDTIRLLQAECNLINLEIPTLNEEKFAITRLKSAKHFFGAVSSLKEGKALECCKEMIKQVDEDGHGRVDYKEFLQMMKTGDFSNR
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML1, Calmodulin-like protein 1.
Protein: RDRP_I06A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMNKEEMGITTHFQRKRRVRDNMTKKMITQRTMGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYMTRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIEGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESMNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGVLEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDTRIDFESGRIKKEEFTEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: RUVB_WOLSU
Sequence: MERIIEIEKMELEEAEEVSLRPSGWDDYIGQEKIKRNLGVFIEAAKRRGEGLDHILFFGPPGLGKTTLAHIISHEMGANIKVTTAPMIEKAGDLAAILTNLSEGDILFIDEIHRLSASIEEILYPAMEDFRLDIIIGSGPAAQTVKIDLPRFTLIGATTRAGMISKPLRERFGMNFWMQFYNIEELSQIITLASIKLKKRCLLESAKEIARRSRGTPRVALRLLRRVRDFAEVANEEEIKIEQARYALHELGVNDHGFDDLDLRYLRILVQSKGRPVGLGTIAAAMSEDEGTIEDVVEPYLLAHGYLERTARGRVATRQTYELFSLPFEPNATLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: UFM1_XENLA
Sequence: MSKVTFKITLTSDPRLPYKVLCVPENTPFTAVLKFAAEEFKVPAATSAIITNDGIGLNPAQTAGNVFLKHGSELRLIPRDRVGSC
What is the function of this protein?
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer.  The so-called ufmylation, requires the ufm1-activating E1 enzyme uba5, the ufm1-conjugating E2 enzyme ufc1, and the ufm1-ligase E3 enzyme ufl1.  Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
What are the official names of this protein?
Ubiquitin-fold modifier 1.
What is the protein family that this protein belongs to?
Belongs to the UFM1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CPFC2_BACCR
Sequence: MKKKKIGLLVMAYGTPESLDDVEAYYTHIRHGRKPSEEALEDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNIFTEYEFTCYLGLKHTAPFIEDAVEEMKRNGIEQTISIVLAPHYSTFSIKAYNDRAIRLSKEIGGPVIESIEQWYDEPKFISYWADQIKETFTEIDDKEKAVVIFSAHSLPEKIIAAGDPYVEQLKHTADLIAEAANIQNYTIGWQSAGNTPDPWIGPDVQDLTKDLYEEHGYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELNAKYFRPNMPNAQSAFIDCLAEIVSKKVKEIVDKDLVLNNN
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase 2.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_PARPJ
Sequence: MKPVIALVGRPNVGKSTLFNRLTRTRDALVADLPGLTRDRHYGEGRAGDRPYLVVDTGGFEPVAKDGILHEMARQTRQAVEESDIVVFIVDGRNGLAPQDKSIADYLRKVGRPIFLVVNKAEGMKYSNVAADFYELGLGDPRAISAAHGDGVTEMINEALEVAYAGQPEESDEEKQTRGVKIAIVGRPNVGKSTLINALVGEERVIAFDMPGTTRDSIYVDFERGGKPYTLIDTAGLRRRGKVFEAIEKFSVVKTLQSISDANVVILLLDARQDISEQDAHIAGFVVEQGRALVVGVNKWDGLDPHVRERTKADLERKLKFLDFAKFHFISAAEKTGIGPLMRSVDDAYAAAMAKLPTPKLTRALIDAVEFQQPRRRGPVRPKLRYAHQGGQNPPIIVIHGNALDAITETYKRYLENRFRETFKLTGTPLRIEFRSSTNPYADKG
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: KEFB_CROS8
Sequence: MEGSDLLLAGILFLFAAVVAVPIAARLGIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFLIGLELNPSKLWKLRRSIFGIGAAQVLLSAVVLAGLLMLTDFAWQAAVVGGIGLAMSSTAMALQLMRDKGMNRTEGGQLGFSVLLFQDLAVIPALAMVPLLAGNGDEHPDWLKIGMKVLAFAVMLVGGRYLLRPVFRFIAGSGVREVFTAAALLLVLGSALFMDLLGLSMALGTFIAGILLAESEYRHELEIAIEPFKGLLLGLFFISVGMALNLGVLYTHILWVVMSVVVLVSVKMAVLYGLGRFQGLRRTERLPFAGVLSQGGEFAFVLFSSASSQKLFHNDQMALLLVTVTLSMMTTPLVMKGIDRLLARHFNAPDEDAEMPYVEDDKPQVIIVGFGRFGQVIGRLLMANKMRITVLERDISAVNLMRKYGYKVYYGDATELELLRAAGAESAQSIVVTCNDPEDTMRIVHLCQQHFPQMEILARARGRVEAHELLQAGVKQFSRETFSSALELGRKTLISLGMHPHQAQRAQLHFRRLDMRMLRELMPVHTDNAQISRVREARRELEEIFHREMQQERRQLDGWDEFE
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefB, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTDA_METEA
Sequence: MSKKLLFQFDTDATPSVFDVVVGYDGGADHITGYGNVTPDNVGAYVDGTIYTRGGKEKQSTAIFVGGGDMAAGERVFEAVKKRFFGPFRVSCMLDSNGSNTTAAAGVALVVKAAGGSVKGKKAVVLAGTGPVGMRSAALLAGEGAEVVLCGRKLDKAQAAADSVNKRFKVNVTAAETADDASRAEAVKGAHFVFTAGAIGLELLPQAAWQNESSIEIVADYNAQPPLGIGGIDATDKGKEYGGKRAFGALGIGGLKLKLHRACIAKLFESSEGVFDAEEIYKLAKEMA
What is the function of this protein?
Catalyzes the dehydrogenation of methylene-H(4)MPT.  Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency.
What are the official names of this protein?
Bifunctional protein MdtA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_TMV06
Sequence: MSYSITTPSHFVFLSSAWADPIELINLCTNALGNQFQTQQARTVVQRQFSEVWKPSPQVTVRFPDRDFKVYRYNAVLDPLVTALLGAFDTRNRIIEVENQANPTTAETLDATRRVDDATVAIRSAINNLMVELIRGTGSYNRSSFESSSGLVWTSGPAT
What is the function of this protein?
Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: RL19_FRACC
Sequence: MHTLDSLDAESLRTDVPEFWPGDTLKVHVRVVEGNRQRIQVFQGAVIRRQGGGVRETFTVRKVSFGVGVERTFPLHSPIVSKIEIVSRGDVRRAKLYYLRQLRGKAAKIKEKREPVAR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RISB_BDEBA
Sequence: MGKIKVGVVTARWNQEITSKLEEGAISYLEACEDVEIFAALVPGAVEIPLACQAFLEAGCDGVVALGVVIRGDTSHYDYVCNSVTDGVTRLMLDYKKPIGFGVLTTENEEQALARAGGDHGNKGEEAAQVTMEMIGLTQEIPAAMKTALMLAKKAPAKAAKKPAKAAAKTQKKKKKVRK
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: CHED_BURP1
Sequence: MSGLPIATNLYFDAHFHRHGVKLLPNEFYTTREDMVLVTVLGSCVAACLHDPIGRIGGMNHFMLPDDGADPSAAASESMRYGAYAMEVLINELIKAGGRRERFEAKVFGGAAVLAGMTTINIGDRNADFVRRYLALERIRITAEDLQGVHPRKVAFMPHTGQAMVKKLRVQAPDVAAREAALAREAVDPHGERAPRVRPRVELFGTPAPKAQAKPRIELFGMRAMQPATRKQEA
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: STX8_RAT
Sequence: MAPDPWFSTYDSTCQIAQEIAEKIQERNQCERRGEKTPKLTLTIRTLLKNLKVKIDLLKDLLLRAVSTRQITQLEGDRRQNLLDDLVTRERLLLASFKNEGSEPDLIRSSLMSEEAKRGTPNPWLCEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRTEARRVTLVDRKSASCGMIMVILLLLVAIVVVAVWPTN
What is the function of this protein?
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
What are the official names of this protein?
Syntaxin-8.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein. Note=Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits.
Protein: BETB_BURPS
Sequence: MSVYGLQRLYIAGAHADATSGKTFDTFDPATGELLARVQQASADDVDRAVASAREGQREWAAMTAMQRSRILRRAVELLRERNDALAELEMRDTGKPIAETRAVDIVTGADVIEYYAGLATAIEGLQVPLRPESFVYTRREPLGVCAGIGAWNYPIQIACWKSAPALAAGNAMIFKPSEVTPLSALKLAEIYTEAGVPAGVFNVVQGDGSVGALLSAHPGIAKVSFTGGVETGKKVMSLAGASSLKEVTMELGGKSPLIVFDDADLDRAADIAVTANFFSAGQVCTNGTRVFVQQAVKDAFVERVLARVARIRVGKPSDPDTNFGPLASAAQLDKVLGYIDSGKAEGAKLLAGGARLVNDHFASGQYVAPTVFGDCRDDMRIVREEIFGPVMSILPFETEDEAIARANATDYGLAAGVVTENLSRAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQVELGRYQPVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: KHSE_SHISS
Sequence: MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCLELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M1_I43A0
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRAIGTHPSSSAGLKNDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: VPS8_YEAST
Sequence: MEQNGLDHDSRSSIDTTINDTQKTFLEFRSYTQLSEKLASSSSYTAPPLNEDGPKGVASAVSQGSESVVSWTTLTHVYSILGAYGGPTCLYPTATYFLMGTSKGCVLIFNYNEHLQTILVPTLSEDPSIHSIRSPVKSIVICSDGTHVAASYETGNICIWNLNVGYRVKPTSEPTNGMTPTPALPAVLHIDDHVNKEITGLDFFGARHTALIVSDRTGKVSLYNGYRRGFWQLVYNSKKILDVNSSKEKLIRSKLSPLISREKISTNLLSVLTTTHFALILLSPHVSLMFQETVEPSVQNSLVVNSSISWTQNCSRVAYSVNNKISVISISSSDFNVQSASHSPEFAESILSIQWIDQLLLGVLTISHQFLVLHPQHDFKILLRLDFLIHDLMIPPNKYFVISRRSFYLLTNYSFKIGKFVSWSDITLRHILKGDYLGALEFIESLLQPYCPLANLLKLDNNTEERTKQLMEPFYNLSLAALRFLIKKDNADYNRVYQLLMVVVRVLQQSSKKLDSIPSLDVFLEQGLEFFELKDNAVYFEVVANIVAQGSVTSISPVLFRSIIDYYAKEENLKVIEDLIIMLNPTTLDVDLAVKLCQKYNLFDLLIYIWNKIFDDYQTPVVDLIYRISNQSEKCVIFNGPQVPPETTIFDYVTYILTGRQYPQNLSISPSDKCSKIQRELSAFIFSGFSIKWPSNSNHKLYICENPEEEPAFPYFHLLLKSNPSRFLAMLNEVFEASLFNDDNDMVASVGEAELVSRQYVIDLLLDAMKDTGNSDNIRVLVAIFIATSISKYPQFIKVSNQALDCVVNTICSSRVQGIYEISQIALESLLPYYHSRTTENFILELKEKNFNKVLFHIYKSENKYASALSLILETKDIEKEYNTDIVSITDYILKKCPPGSLECGKVTEVIETNFDLLLSRIGIEKCVTIFSDFDYNLHQEILEVKNEETQQKYLDKLFSTPNINNKVDKRLRNLHIELNCKYKSKREMILWLNGTVLSNAESLQILDLLNQDSNFEAAAIIHERLESFNLAVRDLLSFIEQCLNEGKTNISTLLESLRRAFDDCNSAGTEKKSCWILLITFLITLYGKYPSHDERKDLCNKLLQEAFLGLVRSKSSSQKDSGGEFWEIMSSVLEHQDVILMKVQDLKQLLLNVFNTYKLERSLSELIQKIIEDSSQDLVQQYRKFLSEGWSIHTDDCEICGKKIWGAGLDPLLFLAWENVQRHQDMISVDLKTPLVIFKCHHGFHQTCLENLAQKPDEYSCLICQTESNPKIV
What is the function of this protein?
Required for localization and recycling of the CPY sorting receptor (VPS10) to the late-Golgi compartment.  Involved in the retention of proteins to the late-Golgi.  Plays an integral role in the complex vacuolar protein sorting process.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 8, Vacuolar protein-targeting protein 8.
What is the protein family that this protein belongs to?
Belongs to the VPS8 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack. Note=Associated with the late-Golgi membranes.
Protein: EFG_FRATT
Sequence: MPRNTALEKYRNIGICAHVDAGKTTTTERILFYTGLSHKIGEVHDGAATMDWMEQEQERGITITSAATTTFWSGMDQQFEKHRINIIDTPGHVDFTIEVERSLRVLDGAVVVFCGSSGVEPQSETVWRQANKYGVPRIVFVNKMDRSGADFERVCAQIKTRLKANVVPVQLNIGAEEDFKGVIDLIRMKAIMWNEEDMGLTYELVDIPADLQDRAEELRMEMIEAAAEASEELMEKYLEGGELSEDEIHQGLRARVLNNEIVLAFCGSAFKNKGVQAVLDGVVRYLPAPNQVPAIKCETEDGEPASRPSSDDAPFAALAFKLATDPFVGNLTFIRVYSGVLKSGDAVYNPVKGKKERVGRIVQMHANKRDEIKEVRAGDIAACIGLKDVTTGDTLCDQEDVVILEKMDFPEPVISVAVEPKSKADQEKMSIALGKLAAEDPSFRVKTDEESGQTIISGMGELHLDIVVDRMRREFKVEANVGNPQVAYRETIRSKVEQEAKFVRQSGGRGQYGHVFVRFEPLDEVDENGEAKVFKFVDEVVGGVVPKEYIGSVAKGIEEQLNNGVLAGYPMIGVKATLYDGSYHDVDSSEMAFKIAGSMALKEGAKKANACILEPIMKVEVVTPEDYLGDVMGDLNRRRGIIEGMDENPSGRVINALVPLAEMFGYATNVRSISQGRASFSMEFKKYAEVPNNIADEIIKSHNS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_KORVE
Sequence: MLMIRLSRRGARKQPHYRIVVIEKDRARDGRSVEVVGTYNPRTNPGSIELKRERVEYWVSKGAQMSDRVKKLWDKTPAAPASVA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: DNAE2_VIBVY
Sequence: MFYAELFCQSNFSFLTGASHPEELIVQANFLGYHSLAITDECSLAGIVRAHSAIKQHQLSVKQIVGSFFKLNTECQFVLLCPNREAYAELCRIITNARRRCEKGQYQLSQWDVMSLKHCLLIWLPTGQTSDEQWATWLSRYQQSRLWLGLQRHLHHDDEHYLHHCQTLANQFDLPITACGGVLMHRPERLPLQHTLTAIRHGCTVEQLGTQLLTNAEQSLRSEKKLRKLFKPQWLAESLYIASLCSFDLDSLRYEYPSELIPDGYTPDSYLEHLVEQGKKLRFPEGVPDAIEQTIQKELALIKEQKYPFFFLTIHDIVMFAKQQGILYQGRGSAANSVVCYCLQITSVDPRQIAVLFERFISKERDEPPDIDVDFEHERREEVIQYIYQKYGRQRAALAATVISYRFKSAVRQVGKALGIEETQLDFFLKNINRRDRQAGWQVQLVELGLRPDSLKGQHFIQLVEEIIGFPRHLSQHVGGFVISSGPLYELVPVENAAMPERTIIQWDKDDLESLKLLKVDVLSLGMLTAIRKCFRSIEQHHQQRLSIADITRRQDDQAVYKMIQKADTIGVFQIESRAQMSMLPRLKPACYYDLVIQIAIVRPGPIQGDMVHPFLKRRDGEEPISYPSVHVQEVLERTLGVPIFQEQVIKLAMVAAGFSGGEADQLRRAMAAWKKNGHVFKFKTKLINGMLERGYELDFAERIFEQICGFGEYGFPESHSASFAVLAYCSAWLKHYYPAEFYTALLNSQPMGFYSPSQLVQDAKRHGIAVLPICVNFSNPEHQLVRLTSGELAIRLGFNLIKGLSHEGITRLLTHRPAQGYQCISEVKQILRQAKDIQSLASANAFYQLADNRYLARWQVMDNLDELPLFQTLPSISNNPLPKPSDYQNVLEDYAATGLSLAEHPVAMLEKAGGLTRFTRANQLNQCSHRSLVTVIGLVTGKQSPGTAAGVTFFTLEDDTGNINVVVWQATSRAQKQAYLTARLLMVKGILEREGDVIHVIAGRLVDLTEKLSGLSPKSREFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL725_MIMIV
Sequence: MANNLVQLIFDQFIEILEDLAAKDEWCFDFNKCDFDFRVRELVNHRLLDVKYTIKDECGRPRDVIQEIDITGICYEDLTTCKWVDYLTKLAVEYINNICPPRYIIIKEEPKKCRPQLPEWNPFPCKRTTTIYRRQKPVEKKPECEVIFEKGCECLPSCEREVPVPKEQIFIKYEPVPAKCCERTVLVRSPEQNRHSFGVHKGNIDYNNHVWPKCCQSKKCNCAH
What are the official names of this protein?
Uncharacterized protein L725.
What are the subcellular locations of this protein?
Virion.
Protein: COX2_ZANCU
Sequence: MNIFSFYIINNDAPEPWQICYQDSATKIMSGIDKLTGEIFYYETLLLIIVGWVLISAIIKYTKTELSYKYFNHGTLIEILWTCSPAFILIAISFPSFKLLYLMDSIIDSQITIKVLGHQWYWSYEYSDYLDNSGDSISFDSIMIPTDDLEPGQFRLLEVDNRIVLPIHTHIRFICTSSDVIHSFAVPSLGLKIDALPGRLNGISTYVEREGTFYGQCSELCGVYHFGMPIVIEAVRIEKYLEWLNIHLDNTPSS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.