PharMolix/UniProtQA huggingface dataset:
Protein: SCTL_SHIFL
Sequence: MKVCNMQKGTLPVSRHHAYDGVVIKRIEKELCKTIKDRDTESKKKAICVIKEATKKAESLRIDAVCDGYQIGIQTAFEHIIDYICEWKLKQNENRRNIEDYITSLLSENLHDERIISTLLEQWLSSLRNTVTELKVVLPKCNLALRKKLELDLHKYRSDVKIILKYSEGNNYIFCSGNQVVEFSPQDVISGVKIELAEKLTKNDKKYFKELAHKKLRQIAEDLLKENPVND
What is the function of this protein?
Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:12864857, PubMed:29595954).  Acts as a regulator of the Spa47/SctN ATPase activity (PubMed:29595954).  It down-regulates the ATPase activity of the oligomeric Spa47/SctN, while it up-regulates the activity of the monomeric form (PubMed:29595954).  Important for translocation of MxiH/SctF, the major needle component (PubMed:25583506).
What are the official names of this protein?
Type 3 secretion system stator protein, T3SS stator protein, MxiN spoke protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMA_ALIB4
Sequence: MNCNYFGICASCTLFDKTYEEQLNYKIQREKERFSNFTNIDFDIIKSNESNFRNRAEFRIWWEKGENNKEILSYAMNDFKKNILKINSCEMVSFHIKELMPKLIDELQNDLELSFKLFAVEFLGSSTKDMLVTLIYHKKLEESWIQKAKEIEKKLNIKIIGRSKKQRLVLTNDYINETLNISNQNFFFAYEENGFTQPNTNVNVQMIEWVLENTKNSSKDLCELYCGGGNFTIPLSTKFRKVLATEISKTSIKSALRNCSLNKIESISFIRMSAEDFVQALNKVRAFNRLKDINLDDYEFDTIFMDPPRSGLDDTTRNLAKDFENIIYISCNPETLHRDLEELTKTHEIEKFALFDQFAFTNHIESGVILRKLKD
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: PHZD2_PSEAE
Sequence: MSGIPEITAYPLPTAQQLPANLARWSLEPRRAVLLVHDMQRYFLRPLPESLRAGLVANAARLRRWCVEQGVQIAYTAQPGSMTEEQRGLLKDFWGPGMRASPADREVVEELAPGPDDWLLTKWRYSAFFHSDLLQRMRAAGRDQLVLCGVYAHVGVLISTVDAYSNDIQPFLVADAIADFSEAHHRMALEYAASRCAMVVTTDEVLE
What is the function of this protein?
Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control.  PhzD2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development (PubMed:23129634).  Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) (PubMed:23129634, PubMed:12741825).  Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates (PubMed:12741825).
What are the official names of this protein?
Phenazine biosynthesis protein PhzD2, 2-amino-4-deoxychorismate hydrolase, Isochorismatase, Trans-2,3-dihydro-3-hydroxyanthranilic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family.
Protein: CHO2_TRIVH
Sequence: MARLSGVERPDDSGLRERKARAVEEPVKQPVESADGAAAAAQAKKKTIGRTPDGTAFTVPHTRDMVSQLLSPSEPKNLSDILVLSIIGLHIVLLYLLPSFLRIPIFAVLFLSWRAAYNIGIGWLLHMQSNHSTMVLWARQTKIFVNPATGDNPHPQLYSFIKRELETKIPEDYSFEDAPIEYNTWLVFRRVVDLILMCDFTSYCLFAIACGSRPAEENFLVLILRWVVGLGLVLFNLWVKLDAHRVVKDFAWYWGDFFYLVDQELTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKVLFISILAHAAQFAFLVLVENPHIEKTYNAPPPRKRTIESHAGLAGEEKSSRRPSDSSEMVPPPSPVALPSSTHNLVGVKNLDLHRITDSSIILIQVLFFALTMLTPSTPIYQFFFVLNAAIWRLWYSVGIGYILNCQSHRREWTRHFVKFGETKEEAWNQWKGTYHLSMTLCYASFIAAAWKMYTLPENWGYGLAILKHVLGAGLIALQIWTSVSIYDSLGEFGWFFGDFFFDEAPKLTYSGIYRFLNNPERVLGLAGVWGAALITSSRAMIFLALLSHTLGIAFIQLVERPHMQKLYGRGLRQDAGLVRSIKRSLPPSFKQLHGSVDRILDESIEFIEEVLDTARPKLAAGVTTFVKDTSELFHKYPARITITRIEPDLAGYDMNDYSINVDTSDCITIRDGAEDKSEVLVFEYGSPIKVNWTAPLNHSKRDWVGLYMIGQNPSREVTNVSSWGRWVATNHGSFDSVLSEKGLIASDVVVSKPGTSNTSKKPSVKSGSGKKSSTSTSSHEVASGQMVFSGDKLWWTQGVFEFRYHHNGKHNVMATSRPFEIRIPKFDDGQIPSHVSSNGNGFMTTAIEQALLPIVQNCFDRDPEISPQTAEEPFGCETEGDLKYAKRVVYAVHQMFGIEFATEVVRADGNVQNLAWRICNAKKVLAPYSMRKSNGASTPTGESEEMK
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PRRT2_RAT
Sequence: MAASSSEVSEMKGVEDSSNTHSEGPRHSEEGMGPVQVVAENLDQPEALQSGPDTTAAPVDSGPKAELAPETTETPVETPETVQATDLSVNPGEDSKTCPSPKEACQEPASRPEVNREATAEQGAEQQSAAPPEPTSEQALQLNTQSDPQPTSQPPPKPPLQAEPPTQENPTTEVLTESTGEKQENGAVVPLQAGDGEEGPAPQPHSPPSTKTPPANGAPPRVLQKLVEEDRIGRAHGGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK
What is the function of this protein?
As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system.  In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing.  In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation.
What are the official names of this protein?
Proline-rich transmembrane protein 2, Dispanin subfamily B member 3, DSPB3.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Presynaptic cell membrane; Single-pass membrane protein. Synapse. Cell projection, axon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Postsynaptic density membrane. Cell projection, dendritic spine.
Protein: MRAY_METCA
Sequence: MLLILANWLEHYFDVFRVFHYLTLRGILGILTALVISFIVGPPMIRYLGSYKIGQTIRDDGPQSHLSKAGTPTMGGALILVTITVSTLLWSDLGNRYVWAVLLVTLAYGLIGFVDDYKKLVLKNSKGLAARYKYLWQSVFGLGAALFLYHTASSPQETQFIVPFFKQVVLNMGWLYVPLVYFVVVGSSNAVNLTDGLDGLAILPTVLVAGGLAIFAYASGHSEFSEYLGIPYLPKAGELVVFCGALVGAGLGFLWFNTYPAQVFMGDIGALALGAALGMVAVLVRQEIVLMIMGGIFVMETVSVMLQVLSFKLTGRRIFRMAPIHHHFELKGWPEPRVIVRFWIISVILVLIGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RDRP_FDVS
Sequence: MIVRTVCRAKEKCLEKYKNILKYKEQLAKQDQKENETTSNNKDTSSSVPKPSNFRKTKVQNQYNRVFSIDEKVAEYEKILNDKVNMIDAIFNKAEKIRDLFIGTEPLTKELIKNELQYGAIVLNRASDLILAFADNNEPREPEFVLNTDMIVNDLKPLLHPTRIFDYSSFGFDDVNKLAINPKIRYLPNWSINYIRKCIQSFFTSNSNIEVQNLHNYSNHYDNRIYEHAMPNDVKLQILIGLDKMFNKLSIQHRFGTFETQILSCFFMKQKICEYEAYMHLPDCVNKSKKLKKGTETVCWQYLAEIIKHYEGIPFYHHTHSSKFGALDNTKISITTNKEVSCCLPSVMHGLLNGIIGELLCDLSTETALIYAKHLMNCSATSTYQRQLEFKDSFRMWPKLCYDSIGYALAVLYSKDMKPLEHRVEKIDSEFWFDEEEKDKLSSSLSKIPSYMKPFVNNAIQNCKKRGDYINQMICDINKIKLSREPNKFETHDLYLESGKNTEYLRWLTMTSTIISNFGIYNKTSLLLEYEKSISTKTKVMVQQPEPKVSLITEQGLQTPILHDWTKVPVLNEMSSLFDSEWKSTLVKEFEDINDFEKRFVTFLTNKSGGIKSEEPTLSKELKGISNARIIAFALNRNDYQIESKFLNMLIAHGKCAIRFQIDRRARVIVIVPNAIQSSELFLLLGFNVLKSDKRFNEKIAVGKQIGNLLDAKAQMISSGDVLSVKNSSDMKGMDAHTLPNLTLFLRRKMIEVLYELDPTGKCARYFFAEDKEYCLIQHHEKYHEQFVRRLRGPTIHAAKCLYYMFSMNMYLEDNFFSKGMNVSDQTFQSGFFATSAQHTLFLSLYLLNNERKYFSKLDNRMIRLLHSVMGDDVFEVIVNGVKYPNLVKEWLKLRNQGLSKINYEEDVSLSRLFGVFLQQAAILGVYVPYPARMSLFCDERSDTTKRHTLDMIKIVLEVLSSKSQRSYAIDNNISIGYAIWNCHRTSRYLYTDRDKSLIRRLVDHDANLDKLFVIDLSKFENSVRLVYPFVTIMTSPISWPMLYFAHFKIDDPNCTILTYRAKSPTSLNGDGAFLLINQMFFTSDEEHMFKFVEFVKHQDKVVRLKLSSDFLDWKERHTWGFTLGEHLLRFKRLRHLTESRKSELGLGEIEVMVHNLNKYLDSHRVQMSLDSFDQLRKNKITVPSSLMYVNHNRAKIEQSLTVRTETLDERASLDSTFLRHVFSYSIVPKDIEVLKTHALCAIKVRTYSDLKYALSVDGYLPESDDSSFNVILPFLPGYHQSSSYGRLFRYTTLPTVHDRDISGTMGEIVGGLGASFDIDSAIEFGAYVYNINRNLINAAASAIGIPQKFVSKYEQLVQAFIMNNFNLKYHSIFHNAKYFGLSGSLKKFSEYGGYSNKLIRFDTINKMEKFHNAFTRDLVFAYIDELNGRRVYLDYSIHSLLLIMSRGSIKYFTTHLYKLFNPLLSLELD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in transcription and genome replication.  Following infection, it catalyzes the synthesis of fully conservative plus strands.  After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase VP1.
Protein: RF1_BAUCH
Sequence: MKPSIITKLKVLQERYYEVETLLGNSEVAKDRERLRILSKEYAQLTDIHTCFQHWQQVQENISITGPMLEDPEMHDMVQDELNKLHSLLSTLEQQLLTLLLQKDSNKDPNDERGCFIEVRAGTGGDEAALFAGDLFRMYSRYAEIHSWQIDVISASSGPHGGYKEIIVKMSHDNAYGQLKFESGGHRVQRIPETESQGRIHTSSCTVAVIPDILHAELPEISPEDIRVDTFRSSGAGGQHVNTTESAIRITHLPTGLVVECQDERSQHKNKAKAMAVLSARLRAAEAQCRQQEESCMRRNLLGSGYRSDRIRTYNFPQGRITDHRIGFTTYRLNEVIEGKLEILLQPIIQEYQTNQLIALSESEIT
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERA_PYRAB
Sequence: MEEREERVRDDTIEEFATYLELEGKSRNTVRMYTYYISKFFEEGHSPTARDALRFLAKLKRKGYSTRSLNLVIQALKAYFKFEGLDSEAEKLKTPKMPKTLPKSLTEEEVRRIINAAETLRDRLILLLLYGAGLRVSELCNLRVEDVNFEYGVIVVRGGKGGKDRVVPISESLLSEIKRYLESRNDDSPYLFVEMKRKRKDKLSPKTVWRLVKKYGRKAGVELTPHQLRHSFATHMLERGIDIRIIQELLGHSNLSTTQIYTKVSTKHLKEAVKKAKLVESIIGGS
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Probably involved in the resolution of chromosome dimers at the terminus of replication.  Binds to the dif site.
What are the official names of this protein?
Tyrosine recombinase XerA.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL1_BPV3
Sequence: MSFWLPSQGKLYLPPPTAVTQYLDTDDFVTRTDTFYHTNTERLLFVGHPYFDIKREDKVLVPKVSGSQFRVFRLKFPDPNKFSFPDPNVYNSDNQRLVWALRGIEICRGQPLGIGVTGHPSFNKFKDAENNNNKTPDQTTDDRVNMAVDPKQVQMFIVGCTPCDGEHWDVAQACDRLEPGACPPIELKNTIIEDGEMCDTGFGNMNFQKLQASKSGAPLDIVNQIVKYPDFLKMGSDPHGNSMFFYAKREQMYVRHLWSRGGTIGEEIPPNGEASPYYLPGAGRATLPTSVYFGSPSGSLVSSDQQIYNRPFWIQRAQGRNNGICWNNQLFVTAVDSTRGTNFTISVHRDKPSLEDQDTYTAAEFKHYLRHVEEWEVSLVLQLCIVDLTPEALAHINGMDPRIIESWNLGFIHAPNNIEDQYRYLQSIATRCPPKEDAAATEDPYAKYTFWDVDLTERFSMNLDQYSLGRKFLFQIGKKSRGIKRSAPKAVTFESSSRSKKAPKRRRKNV
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RNP4_HALSA
Sequence: MASIAAERIDRLHTLARAAARTGDDDRAREYVRLARRLAERNRLTLPPAFRRFTCDDCDAVLVPGRNARVRTRSGHVVVTCDCGTHARYPYTG
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 4, RNase P component 4, Rpp21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK2_PERAM
Sequence: SPPFAPRL
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Pyrokinin-2, Pea-PK-2, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YDL6_SCHPO
Sequence: MSKTSCFLKKYRLILLWCILGIAYILFWTHRISKAFASVSSTSDSTVHLFERGNTLNDSNDQILLTCNDIKNITPANQCRFAKAYCKGEASGFFDYVEFYFCTINSLRFPVLSIIVGWLIFLFITIGISASDFFSTNLVTISWLLQLPDSVVGVTFLALGNGSPDILSTFAAVRVNSGGMAIGELLGSAFFIVAIVAGSVCLIKPFKIPRRHFLRDVAFLTGTILLVIMFVLHDGSLSIWQSLVMILYYLLYVLFVFFSGSSGVSVVITDENYLPVSLPVYSPVLNSFDDSDSYSSTDSELSEEAFLLPAQASRKTQKIHYINDNDPSNSYSSYQHSHVHDFIHKNNTHSNRVLSQSSGPIVRPSLLAALDFRSSNEEQHPGLRSLDPLNIQDGDLTMHPMHIRHSQSDFYPSGINTPVSGINYPNLGFSANNSVQSLVSEIFRHPTHTDEDFPLPSPSLSSLLFPTLRNFAKKSWYEKLMDVLAVPSVLIFTLALPVYQCPRLAVDPIYHMDVSNCNPSKPTWSRKLRLLQCVFVPFAFVTFSITGGNRLYIYAASSVFSILCITALYYYTDEEKPPKFLPWVSFIGFVLGIIWISTIANEVVGILRALGVIFNLNESILGLTVFAAGNSLSDLIADIMIARSGFPEMAMGGVFGGPTLNILIGIGISSFYSSISNHGNDSVIEIPHSLSITAYFLLACLLLLLIYVPLNRFRVNRVLGLLLFILYIVGTSTNIVVELLKDK
What is the function of this protein?
Putative cation exchanger.
What are the official names of this protein?
Putative cation exchanger C3A12.06c.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
Protein: COQ7_PARXL
Sequence: MFLDELISEFDRGLRSMTGVSRMSRPLPVPQESAVTEAAPELSPAERAHSAGLMRVNHVGEVCAQALYQAQKLATRSPSLRAVFNHAAIEEEDHLAWTAKRLEALDSRPSLLNPLWYTGALAIGLAAGRMGDRVSLGFMAETERQVEQHLDSHLEQLPEADRESRAIVEQMRVDEVEHGKAAMEAGGIELPFPVRGLMRAVSKVMTRTAYYI
What is the function of this protein?
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
What are the official names of this protein?
3-demethoxyubiquinol 3-hydroxylase, DMQ hydroxylase, 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the COQ7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NEXN_MOUSE
Sequence: MNDVSQKAEIKEMLASDDEEESSPKIEKAYVPKLTGTVKGKFDEMEKHRQEEQRKRTEEERKRRIEQDLLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPAKSYKTPGKTKDPEDLDREEGNGRTNHEEDKMRYEEECRVLKEAKCLSLVMDDETEAKKESHFPGKLKSTFEELERQRQENRKKQAEEEARRRLEEERRSFEEARRHMVNEEDENQDRETVFKEYRPGKLKLSFEEIERQRREDEKRKAEEEARRRIEEEKAAFAEARRSMVLDDDSPEIYKTVSQESLTPGKLEINFEQLLRQKMEEERRRTEEERRHKLEMEKQEFEQLRQEMGKEEEENESFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEVQKKIEEERAKRRAIDLEIKEREAENFHEDDDVDVRPAKKSESPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREDEEEEEGSIVNGSTTEDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIEMDDY
What is the function of this protein?
Involved in regulating cell migration through association with the actin cytoskeleton.  Has an essential role in the maintenance of Z line and sarcomere integrity.
What are the official names of this protein?
Nexilin, F-actin-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ.
Protein: NH2L1_XENTR
Sequence: MTEPEVNPKAYPLADAQLTKTLLDLVQQAANYKQLRKGANEATKTLNRGIAEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACAVTIKEGSQLKPQIQSLQQSIERLLV
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Involved in pre-mRNA splicing as component of the spliceosome.  Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly.  The protein undergoes a conformational change upon RNA-binding.
What are the official names of this protein?
NHP2-like protein 1, High mobility group-like nuclear protein 2 homolog 1, U4/U6.U5 small nuclear ribonucleoprotein SNU13, U4/U6.U5 tri-snRNP 15.5 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: PYRH_EHRCJ
Sequence: MSESSTPNVKYSRVLLKVSGEALMGEKGFGCDVEVLDKLSHDLKEVYDFGIQLCLVVGGGNIFRGASSSSPFGFERASNDYIGMLATMMNALSLQNALEKINVQSRVLSAIPITAVCETYIRRRAIRHLEKGRVVICAAGVGNPFFTTDTAAALRGIEMGCDAIFKGTQVDGVYSADPKKTVDAVRYDRISYRDLLSLDLKIMDVAAVSLAREHSVPIIVFNLGKRGSFADIIRGRGLYTTICN
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_BURCJ
Sequence: MTSSVSRPSGRRADELRKVALTRHYTKHAEGSVLVEFGDTKVLCTASVAERVPEFLRERGQGWLTAEYGMLPRATHTRSDREAARGKQTGRTQEIQRLIGRALRAVFDLEALGPRTLHIDCDVIQADGGTRTASITGAFVAAHDAVSTLIAAGKLTRSPITDHVAAISVGVYEGAPVLDLDYAEDSRCDTDMNVVMTGAGGFVEVQGTAEGVPFSRAEMNALLDLAQGGIAELVQLQKDVLGASHA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: MIAA_PETMO
Sequence: MNKVLVIAGPTAVGKTEISIEIARRINGEIICMDSRQIYSHLIIGTATPDEETKKLVPHHLYGSVDPRTHFTAFDYKKLAEKKIGEVLNRGNTPVLVGGTGLYLDALRKGFLNVKSDYGLRTYLRKLETNNPGVLRKILVDLDPQRAQKIHPNDLKRIIRAIEIYVITGIKMGEIVKENRQDENSFDYHIIVLDRERQELHERINKRVHQMIDEGLIEEVRNLLSLGYSTTLNALNTIGYKEVVQYLYGKIDFNEMVHQIKVNTRNYARRQIIYFRKIEGAKWINLSKTSQEEVVDQILSEFI
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: CAGA_HELPJ
Sequence: MTNEAINQQPQTEAAFNPQQFINNLQVAFIKVDNVVASFDPNQKPIVDKNDRDNRQAFEKISQLREEFANKAIKNPTKKNQYFSSFISKSNDLIDKDNLIDTGSSIKSFQKFGTQRYQIFMNWVSHQNDPSKINTQKIRGFMENIIQPPISDDKEKAEFLRSAKQAFAGIIIGNQIRSDQKFMGVFDESLKERQEAEKNGEPNGDPTGGDWLDIFLSFVFNKKQSSDLKETLNQEPVPHVQPDVATTTTDIQSLPPEARDLLDERGNFSKFTLGDMNMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYGNNGGPEARHDWNATVGYKNQRGDNVATLINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIQNKVDFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDSKAYLDALGNDHIAFVSKKDKKHLALVAEFGNGELSYTLKDYGKKADKALDREAKTTLQGSLKHDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEAGFSKVAVFNLPNLNNLAITSVVRQDLEDKLIAKGLSPQEANKLVKDFLSSNKELVGKALNFNKAVAEAKNTGNYDEVKQAQKDLEKSLKKRERLEKDVAKNLESKSGNKNKMEAKSQANSQKDEIFALINKEANRDARAIAYAQNLKGIKRELSDKLENINKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSVAKATGDFSGVEQALADLKNFSKEQLAQQAQKNEDFNTGKNSALYQSVKNGVNGTLVGNGLSKAEATTLSKNFSDIKKELNAKLGNFNNNNNNGLENSTEPIYTQVAKKVKAKIDRLDQIASGLGDVGQAASFLLKRHDKVDDLSKVGLSANHEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSREQKLTQKIDNLNQAVSEAKASHFDNLDQMIDKLKDSTKKNVVNLYVESAKKVPTSLSAKLDNYATNSHTRINSNVKNGTINEKATGMLTQKNSEWLKLVNDKIVAHNVGSAPLSAYDKIGFNQKNMKDYSDSFKFSTRLSNAVKDIKSGFVQFLTNIFSMGSYSLMKASVEHGVKNTNTKGGFQKS
What is the function of this protein?
May be necessary for the transcription, folding, export, or function of the cytotoxin.
What are the official names of this protein?
Cytotoxicity-associated immunodominant antigen, 120 kDa protein, CAG pathogenicity island protein 26.
Protein: DNAA_STRP3
Sequence: MTENEQIFWNRVLELAQSQLKQATYEFFVHDARLLKVDKHIATIYLDQMKELFWEKNLKDVILTAGFEVYNAQISVDYVFEEDLMIEQNQTKINQKPKQQALNSLPTVTSDLNSKYSFENFIQGDENRWAVAASIAVANTPGTTYNPLFIWGGPGLGKTHLLNAIGNSVLLENPNARIKYITAENFINEFVIHIRLDTMDELKEKFRNLDLLLIDDIQSLAKKTLSGTQEEFFNTFNALHNNNKQIVLTSDRTPDHLNDLEDRLVTRFKWGLTVNITPPDFETRVAILTNKIQEYNFIFPQDTIEYLAGQFDSNVRDLEGALKDISLVANFKQIDTITVDIAAEAIRARKQDGPKMTVIPIEEIQAQVGKFYGVTVKEIKATKRTQNIVLARQVAMFLAREMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMISQDESLRIEIETIKNKIK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2864_GEOMG
Sequence: MSLHNKSLGSKGESLAVTYLERHRYKILERNFRCRGGEIDIVARDGKTIVFVEVKTRTSGHYGPPQLAVTSFKQRQISKAALTWLAKQRQLDACARFDVISITFSGQMPQIEHIPNAFELAY
What are the official names of this protein?
UPF0102 protein Gmet_2864.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: CA18_CONMR
Sequence: MGMRMMFTVFLLVVLATTVVSFTSNRVLDPAFRRRNAAAKASDLIALNARRPECCTHPACHVSNPELCG
What is the function of this protein?
Acts as a weak partial agonist at alpha-7/CHRNA7 nicotinic acetylcholine receptors (nAChR) when tested in human SH-SY5Y neuroblastoma cells (PubMed:24351107).  Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity).
What are the official names of this protein?
Alpha-conotoxin Mr1.7a, Conotoxin Mr1.8.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.