PharMolix/UniProtQA huggingface dataset:
Protein: MATK_PICMA
Sequence: MDEFHRYGKEDSSWQQCFLYPLFFQEDLYAISHDHYLDGSSSSEPMEHLSSNDQFSFLTVKRLIGQIRQQNHSIVLFVNCDPNPLVDRKKSSYSESVLEGLTLVLEVPFSIRSKYSVEGMNEWKSFRSIHSIFPFLEDKFPHSNYVSDTRIPYSIHPEILVRTFRRWIGDAPSLHPLRSILYEYRNSSESLQRSIIVVPKVNTRFFLFLWNNYVYECESILVSLLKRSSHSRSLSHGSFPQRTHFHRKIKNIFLFSRRNSFQSIWSLKDPNIHYVRYGERSIIAIKGTHLLVKKYRYYLPIFRQCYFHLWNEPYRVCFHQLSKNCSSSLGYFLRVRMKPLLVKTKMLDELFIADLITDEFDPIVPIVPIIGLLSREKFCDISGRPISKLSWTSLTDDDILDRFDRIWRNIFHYYSGSFGRDGLYRIKYILSLSCAKTLACKHKSTIRVVRKELGPELFKKSFSKERELDSPPFSSKAAARSQRERIWHSDIPQINPLAHSWQKIQDLKIENLFDQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CE57L_HUMAN
Sequence: MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ
What is the function of this protein?
Centrosomal protein which may be required for microtubule attachment to centrosomes.
What are the official names of this protein?
Centrosomal protein CEP57L1, Centrosomal protein 57kDa-like protein 1, Centrosomal protein of 57 kDa-related protein, Cep57R, Cep57-related protein.
What is the protein family that this protein belongs to?
Belongs to the translokin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: RLA0_SCHPO
Sequence: MAISKESKAQYFEKLRSLFEKYNSLFVVNIDNVSSQQMHTVRKQLRGTAELIMGKNTMIRRAMRGIINDMPELERLLPVVRGNVGFVFTNADLKEVRETIIANVIAAPARPNAIAPLDVFVPAGNTGMEPGKTSFFQALGIPTKITRGTIEITSDVHLVSKDAKVGPSEATLLNMLNISPFTYGMDVLTIYDQGNVFSPEILDVSEEDLIGHLLSAASIITAISLGANYPTILSVMHSVVNAYKNLVAVSLATEYTFEGTEQTKAFLADPSAFVVAAAPAAAAGGEAEAPAAEAAAEEEEESDEDMGFGLFD
What is the function of this protein?
Ribosomal protein P0 is the functional equivalent of E. coli protein L10.
What are the official names of this protein?
60S acidic ribosomal protein P0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: HPI_DEIRA
Sequence: MKKNIALMALTGILTLASCGQNGTGTTPTADACATANTCSVTVNISGVSSADFDVTMDGKTTSMTLSNGQKLPVAKTGTVTLTPKAKDGYTTPAAQSTTISSTNLTPSVNFAYTTVPSTGNGNGNGGTTPTQPFTLNITSPTNGAAATTGTPIRVVFTSSVALSSATCKIGNSAAVNAQVSSTGGYCDVTPTTAGGGLITVTGTANGQTVSSTVTVDVKAPVVDNRYGTVTPAGDQELTLTNEGIVKDADNGWRRLGQGVSTPSDPNGNVDIYVKGTVNFSVNAAAGSKVEVFLARTTGSDVPTNDDVQAGDVLRSVASTSGTETFSLDSRRLAEFDGVRKWIVVRINGTQVTYQPVIADNKGPQQPDPELNGVQNAYSNILNNYNNSGLTYVRGDVNVFTGNPSLQDREFGQAPLGSSFVQRRPSGFESIRYYLVPETAFGNKALQESDEMLRAKAIKSVATVVSAPVLEPGTVKATSFSRVIGSGATSTVTPKAQDNVTYRVYAISRDQLGNETASATYELVRFDNVGPTITGSVIRDTSDLPFASQEPERCLSDIATITLGGITDNAGGVGLNPGQGLTFTLGGRQIQAGQFDTNQLADGEYTIGFNSLTDALGNPVVSAPTNAKVYIDNTDPTVNFNRAVMQGTFASGERVSVESDASDGGCGVYETRLFWDTDNGVVDDATTTPAIGHPVQFARQRVTDGAKADSLNAGWNALQLPNGAGAVYLRALVVDRAGNATISTTPIVVNAKITNQARPLLGGFDAFKRNASAQFMSNSNAISGVNGTAVTPNTTANSALDNILSLDSVGTLTTNAYLPRGATETAITEKIRNVGAYGRFDATQWNRIRDYQLNTDPTLRSAYVNAGNLANQRGNNWRIRTPWVELGSSDTANTQQKFDFNSDLLNDFYFGRTFGNNDNVNLFSYDQFNGIVSGTAGAYSFYGETVQK
What is the function of this protein?
Shape maintenance, possible protection from noxious enzymes or exogenous and unsettling DNA, and may mediate homotypic cell-cell contacts.
What are the official names of this protein?
Hexagonally packed intermediate-layer surface protein.
What are the subcellular locations of this protein?
Secreted, cell wall, S-layer. Note=This bacterium is covered by a S-layer with hexagonal symmetry.
Protein: ACCA_BACHK
Sequence: MAELEFEKPVVELRNKIRELKDYTKNSQMDFSEEIRILEDKLENLEEDIYGNMKVWDRVQIARHAERPTTLDYIEHLFTDFFECHGDRLFGDDAAIVGGIAKYKGMPVTVIGHQRGKDTKENIRRNFGMPHPEGYRKALRLMKQAEKFNRPIICFIDTKGAYPGKAAEERGQSEAIARNLFEMAGLTVPVICIVIGEGGSGGALGLGVGDYIHMLENSTYSVITPEGAAAILWKDAGKAKEAAEAMRITAADLKELGVIDEIIPEAKGGAHRNVLKQSENIDLMLRKTFEQLNGISKDELIEKRYEKYMKIGQVSFSNASIWIK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YKUC_BACSU
Sequence: MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSYTTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLVFCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYNTIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILYILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLAGSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIAIGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVIILLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV
What are the official names of this protein?
Uncharacterized MFS-type transporter YkuC.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPT_ECODH
Sequence: MKRISTTITTTITITTGNGAG
What is the function of this protein?
This protein is involved in control of the biosynthesis of threonine.
What are the official names of this protein?
thr operon leader peptide, thr operon attenuator.
What is the protein family that this protein belongs to?
Belongs to the thr operon leader peptide family.
Protein: COBS_RALPJ
Sequence: MNALREHWQALWTAVGYFTRIPVPASVGFSQAGLNRAARYFPLIGWLVGAVAAAVYWLVLRTVPAQGVAVAVSMGATLLLTGAFHEDGLADCADGFGGGYTPEDRLRIMHDSRIGAFGAIAVCMALLLKWQLLSAMAPHSIGILVAMVAAHAASRAAAVSHLLTHDYVRAEGKAKPVAQRMRWSDALWAGVFGVVPLLWFGPMCAALIVVGLILARWLLGRYFVRRIGGITGDCLGMAQQIFELLILWGLLAWMSS
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y4FH_SINFN
Sequence: MMLYSAQISTYYDFKKRVFQLYYYTGDTAMTSESAAVESAVVIISKASIINKFLAIDAGDHDAESMLASGDFNFAVSRSVRMSCDWCYWLRFLSDFPPFFAQ
What are the official names of this protein?
Uncharacterized protein y4fH.
Protein: IF5A_METMA
Sequence: MKQQVEVKELKEGKYVIIDDEACVIKSITKSKPGKHGAAKARVEAIGLFDGQKRSYIGSVANKVYVPIVERKSAQVISITGDIAQLMDMGDFSTFEIVIPDELKDRVKEGEEVSYITALGKVKLDIRT
What is the function of this protein?
Functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Translation initiation factor 5A, Hypusine-containing protein, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSD_CALPD
Sequence: MNGTEGPNFYVPFSNKTGVVRSPFEEPQYYLAEPWQFSCLAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTTTLYTSLHGYFVFGPTGCDLEGFFATLGGEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMVVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSNFGPILMTLPAFFAKTSAVYNPVIYIMLNKQFRTCMLTTLCCGKIPLGDDEASATASKTETSQVAPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Required for photoreceptor cell viability after birth (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: IACS_PIG
Sequence: MAFFSSRVRALFILVLVLPLCSETGFARSKKTRKEPDCDVYRSHLFFCTREMDPICGTNGKSYANPCIFCSEKLGRNEKFDFGHWGHCREYTSAARS
What is the function of this protein?
Inhibits acrosin.
What are the official names of this protein?
Sperm-associated acrosin inhibitor, AI.
What are the subcellular locations of this protein?
Secreted.
Protein: ALLA_PSESM
Sequence: MRTLTIEPLTKDAFAPFGDVIETDGSDHFMINNGSTMRFHRLAEVDTAQPDDKAIISIFRAESLPMPLTIGMLERHPQGSQAFIPLLGNPFLIVVAPVGDAPESALTRAFVSNGRQGVNYHRGVWHHPVLTIEKQDDFLVVDRSGSGNNCDEHYFEENQRLVLDPNPQEG
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: Y986_THEP1
Sequence: MYGLINIGFGNVVAGDRVIAIVNPESSPLKRMKDEAKLEGKLIDATYGRKTRSIIITDSNHIILSAIQPETIAQRFMENFYEIERVLRETKK
What are the official names of this protein?
Putative regulatory protein Tpet_0986.
What is the protein family that this protein belongs to?
Belongs to the RemA family.
Protein: RS20_PARP8
Sequence: MANSAQARKRARQAAKANSHNSALRSKYRTAVKAVRKAIEAGDAAQAAEIFKASAKTLDIIADKKIVHKNKAARHKSRLAAAVKGLQAPAAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: NRDR_CUTAK
Sequence: MRCPFCQHDDSRVLDSRVCEDGTAIRRRRQCPMCERRFTTIERMQMTVHKRNGIEEPFSRDKVIRGVRNACKGRPVTDADLALLGQRVEDGLRARGVAEIPSEEIGLAILGPLRELDSIAYLRFASVYLNYNTIEDFATEIDRLRDESSDKTKSSSRKRLSKQDEPLF
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: HUGA_DOLMA
Sequence: SERPKRVFNIYWNVPTFMCHQYGLYFDEVTNFNIKHNSKDDFQGDKISIFYDPGEFPALLPLKEGNYKIRNGGVPQEGNITIHLQRFIENLDKTYPNRNFNGIGVIDFERWRPIFRQNWGNMMIHKKFSIDLVRNEHPFWDKKMIELEASKRFEKYARLFMEETLKLAKKTRKQADWGYYGYPYCFNMSPNNLVPDCDATAMLENDKMSWLFNNQNVLLPSVYIRHELTPDQRVGLVQGRVKEAVRISNNLKHSPKVLSYWWYVYQDDTNTFLTETDVKKTFQEIAINGGDGIIIWGSSSDVNSLSKCKRLREYLLTVLGPITVNVTETVN
What is the function of this protein?
Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.
What are the official names of this protein?
Hyaluronidase, Hya, Allergen Dol m II, Hyaluronoglucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Secreted.
Protein: T10B_CAEEL
Sequence: MNTIQNIQQLREFLTVYNTLSERCFNACARDYTTSTLTKDEGSCVSQCIDKQMLVNRRFMLVFAEQAPKALFKQGEQSPTEAIKSAKPEPAVPAPEATPVETTPVIEENKQ
What is the function of this protein?
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force.  In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit Tim10B, Mitochondrial import inner membrane translocase subunit Tim9B, Tim-10b, Tim10b.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
Protein: MOAA_LISW6
Sequence: MQLLKDKFGRVHDYIRISVTDRCNLRCVYCMPEEGLTFLPHEKVLSKDEIVSFMELMVQFGIKKVRITGGEPLLRTDIVEIVRGLGAIPEIEDISITTNAMYLAKKAEALKEAGLTRVNISLDSLHADRFQAITRGGRLQKVLDGIQKAEEVGLFPIKLNVVLIKGQNDDEITDFLKFTKDKDINIRFIEYMPIGHAGTSWKEKYLPLDTIFEACDAIGFEYEAVDSIRGNGPSENFRIKGAKGTFGVIHPVSSHFCDSCNRLRLTADGYIKACLYWDEEMNIRPFIHEPVKLMQLVQKAIDNKPENHEMALKLQDEVQSNKPTWRRMSQIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: DGLB_MOUSE
Sequence: MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIVSLTLYLTHRRRLDCPGGVLLSTYLIVLLVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWVAKGIQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGGKMAPYPPCIPEHLDSNSSNRLLTGLKTAAKSVWETRVQFCCCCVGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFTLLHQQQDNISHSREPPEVVTHTPGQPQETELDAEVENCHHYMPFAAAAYGWPLYIYRNPFTGLCRIGGDCCRARDIEYDAVEGDQHNCHFASILKTTGLQYRDFIHISFHDKVYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESETLELGIELQDCVAHKGIAQAARYIHRRLVNDGILSQAFSVAPEYQLVLVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSKSLYEYSKDFVVSLILGMDVIPRLSVTNMEDLKRRILRVIANCNKPKYKILLHGCWYGLFGGSPDNFPTELDEGTQGALTQPLLGEQTLLTRYSPGYCSSDSPLDSPTKYPTLYPPGRIIHLEEEGGSGRFGCCSAAQYRARWAHEAEFSKILIGPKMLIDHMPDVMIRALDRVLADRTACVSCPGQGGSSVP
What is the function of this protein?
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:20159446, PubMed:20147530, PubMed:23103940).  Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (By similarity).  Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses (PubMed:23103940, PubMed:26779719).  Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages (PubMed:31991095).  Plays an important role to support the metabolic and signaling demands of macrophages (PubMed:31991095, PubMed:23103940).
What are the official names of this protein?
Diacylglycerol lipase-beta, DAGL-beta, DAGLbeta, DGL-beta, PUFA-specific triacylglycerol lipase, Sn1-specific diacylglycerol lipase beta.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SRTD3_MOUSE
Sequence: MGGLKRKHSDLEEEEEEEKWDWSPTALRSYQQALLRISLDKVQRSLGPRAPSLRRHVLIHNTLQQLQAAIRLAPAPALPPEPLFLGEEDFSLSTTIGSILRELDTSMDEMEPPLNPAASSSPQNEIVSQADPVFLEALSSRYLGDSGLDDFFLDIDTSAVEKDVALPPPEPPHSLFCSPGSWEWNELDHIMEIILGS
What is the function of this protein?
Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (By similarity).  Plays a role in the late phase response of TLR-induced immune effector expression (PubMed:28750197).  Strong transcriptional coactivator (By similarity).
What are the official names of this protein?
SERTA domain-containing protein 3, Replication protein-binding trans-activator, RPA-binding trans-activator.
What are the subcellular locations of this protein?
Nucleus.
Protein: THT3_MYCTU
Sequence: MQARGQVLITAAELAGMIQAGDPVSILDVRWRLDEPDGHAAYLQGHLPGAVFVSLEDELSDHTIAGRGRHPLPSGASLQATVRRCGIRHDVPVVVYDDWNRAGSARAWWVLTAAGIANVRILDGGLPAWRSAGGSIETGQVSPQLGNVTVLHDDLYAGQRLTLTAQQAGAGGVTLLDARVPERFRGDVEPVDAVAGHIPGAINVPSGSVLADDGTFLGNGALNALLSDHGIDHGGRVGVYCGSGVSAAVIVAALAVIGQDAELFPGSWSEWSSDPTRPVGRGTA
What are the official names of this protein?
Putative thiosulfate sulfurtransferase SseB.
Protein: APX8_ORYSJ
Sequence: MAERIAASLLPAASPSPAPSPPPPRPRVSAAAAASFPCCSTSAGGLRLRSRPSRFPQKAATTRSGRAGAGARAVVRCMAAAAVAASDAAQLKSAREDIREILKTTYCHPIMVRLGWHDSGTYDKNIEEWPQRGGADGSLRFDAELSHGANAGLINALKLIQPIKDKYPGITYADLFQLASATAIEEAGGPKIPMKYGRVDVTAAEQCPPEGRLPDAGPRVPADHLREVFYRMGLDDKEIVALSGAHTLGRSRPDRSGWGKPETKYTKDGPGEPGGQSWTVEWLKFDNSYFKDIKEQRDQDLLVLPTDAALFEDPSFKVYAEKYAEDQEAFFKDYAEAHAKLSDLGAKFDPPEGFSLDDEPAVEEKDPEPAPAPAAAPPPPPVEEKKEAEPTPVPVTVGAAVASSPADDNNGAAPQPEPFVAAKYSYGKKELSDSMKQKIRAEYEGFGGSPDKPLQSNYFLNIMLLIGGLAFLTSLLGS
What is the function of this protein?
Involved in defense response and tolerance to the bacterial pathogen Xanthomonas oryzae pv.  oryzae (Xoo).  Plays an important role in hydrogen peroxide removal during infection by Xoo.  Involved in response to abiotic stress.  Plays a role in hydrogen peroxide removal durings salt stress.
What are the official names of this protein?
Probable L-ascorbate peroxidase 8, chloroplastic, OsAPx8.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ascorbate peroxidase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PYRB_CHESB
Sequence: MTDAPGFPLFPHPHLLGIKGLSPADIELLLERADAAVAISRRPEKKLATLRGRTQINLFFEASTRTQSSFELAGKRLGADVMNMSVASSSTKKGETLLDTAMTLNAMRPDILVVRHSAAGAAALLAQKVGCSVVNAGDGAHEHPTQALLDALTIRRKKGSIAGLVVAICGDVLHSRVARSNILLLNALGARVRVIAPSTLLPSGIGQMGVEPFTKMGEGLAGADVVMMLRLQRERMAGTFVPSVREYFRFFGLDAEKLKAAKEDALVMHPGPMNRGVEIASEVADGPQSVIQEQVEMGVAVRMAVMEALLDPRRNGDGA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: IL1A_MACFA
Sequence: MAKVPDMFEDLKNCYSENEEVSSSIDHLSLNQKSFYDVSYGPLHEGCMDQSVSLSISEISKTSKLTFKQSMVVVSTNGKVLKKRRLSLSQSITDNNLEAIANDSEEEIIKPRSAPFSFLSNMTYHFIRIIKHEFILNDTLNQTIIRANDQYLTAAAIHNLDEAVKFDMGAYTSSKDDTKVPVILRISKTQLYVSAQDEDQPVLLKEMPEIPKTITGSETNFLFFWETHGTKNYFISVAHPNLFIATKHDNWVCLAKGLPSITDFQILENQA
What is the function of this protein?
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems.  After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex.  Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4.  In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways.  Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage.  In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
What are the official names of this protein?
Interleukin-1 alpha, IL-1 alpha, Hematopoietin-1.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. Recruited to DNA damage sites and secreted after genotoxic stress.
Protein: CLPS_ALISL
Sequence: MSKFYEWISPDSDVLELEKTGLKPPPMYKVVLNNDDYTPMEFVVEVLDKFFSMDLEKATQLMLTVHYEGKAVCGVFTAEVAETKVAQVNIYSRDNEHPLLCTMEQA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: DCTA_LEPCP
Sequence: MHTPSGPLPFYRSLYFQVITAIVIGVLLGHYWPETGTAMKPLGDGFIKLIKMIIAPIIFCTVVVGIAGMEDMKRVGKTGGLALLYFEVVSTLALLLGLLIVNLVQPGVGMHVDPATLDTKGIAAYTAPGKMQTTTEFLLAVIPTTVVDAFAKGEMLQVLLFSVMFGFALHQFGGRGTLVFDFIEKTSHVLFAIVGFIMKVAPIGAFGAMAFTIGKYGLGSLIPLAKLMGTFYATCLVFIFGVLGLIAKAHGFSIWKFIKYIKEELLIVLGTSSSESVLPRMMAKLENLGVRKSTVGLVVPTGYSFNLDGTSIYLTMAAVFIAQATDTPMTLTQQLTLLAVLLLTSKGAAGVTGSGFIVLAATLSAVGGVPVAGLALILGIDRFMSEARALTNLIGNGVATVVVGKWTGDLDEKQMRYHLDRETEAEANEPEAVLDEIDQHMPVPAAR
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYTSA_MOUSE
Sequence: MKKANRSAGSVPKVSGISKPQTVEKSKPENSSSAPTGVKPVRPGAAAALSKTKSNDDLLAGMAGGVNVTNGIKAKKSTCSSAAPSAPAPAMTISENKSKISTGTSSSAKRSTSAGNKESSSTRERLRERTRLNQSKKLPSVSQGANDVALAKRSRSRTAAEGDIRMSKSKSDNQISDKAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGISEDHCEGEDRSEVKETIIAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPGNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGVPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFGRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDTIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSELEEKDTERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKTLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPNAAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTALSDKRSNYGELPVQEHLLRTSSTSRPASLPRVPAMESAKTISVSRRSSEEMKRDISASEGASPASLMAMGTTSPQLSLSSSPTASVTPSTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQNIDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKKRNFTLAFQAAESVGIKSTLDINEMARTERPDWQNVMLYVTAIYKYFET
What is the function of this protein?
Involved in cytokinesis and spindle organization.  May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
What are the official names of this protein?
Cytospin-A, SPECC1-like protein, Sperm antigen with calponin homology and coiled-coil domains 1-like.
What is the protein family that this protein belongs to?
Belongs to the cytospin-A family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell junction, gap junction. Note=Colocalizes with beta-tubulin, acetylated alpha-tubulin and F- actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center (By similarity).