PharMolix/UniProtQA huggingface dataset:
Protein: BREF2_EUPBR
Sequence: MPGRELAPRQNVEFQTLDGLTLRGWLFPAQSRGPAVIITPGFNCVKEMFVSEVAESFQHSDVTALVYDPRTLGDSGGLPRNNIDPLAQVSDYSDALTFLKTLPIVDQTNISFWGMSFSALVALNAAALDKRARCCIAVCPLTGMQPEPDMLPKVLARCMQDRESQVVGNPPVTISVLTEQGRNPAGMGIGADKMEYDYMVNAKFRGAPNYENRTTLQSYYKMMAWQPFEIMKYLSKTRVLMIIPENDTISPADKQQVLFDGLPEPKTAHIAKGKGHLDVLSGADYEILAEMQAYFIKGPRGKGNAPSA
What is the function of this protein?
Thiohydrolase; part of the gene cluster that mediates the biosynthesis of brefeldin A (BFA), a protein transport inhibitor that shows antiviral, antifungal, and antitumor properties (PubMed:24845309).  The proposed biosynthesis of BFA involves formation of an acyclic polyketide chain that is differentially tailored throughout the backbone (PubMed:24845309).  The highly reducing polyketide synthase Bref-PKS is proposed to synthesize the precisely reduced octaketide precursor, which could then be directly offloaded by the thiohydrolase enzyme Bref-TH followed by a cytochrome P450 monooxygenase-mediated formation of the cyclopentane ring and macrocyclization to afford 7-deoxy BFA.  Alternatively, the first ring annulation can also occur on the ACP-tethered intermediate before the thiohydrolase release and lactonization (PubMed:24845309).  The C7-hydroxylation by another cytochrome P450 monooxygenase is believed to be the final step in the process to obtain the final structure of BFA (PubMed:24845309).  In addition to the HRPKS Bref-PKS and the thiohydrolase Bref-TH, the brefeldin A biosynthesis cluster contains 4 cytochrome p450 monooxygenases (called orf3 to orf6), as well a the probable cluster-specific transcription regulator orf8 (PubMed:24845309).
What are the official names of this protein?
Thiohydrolase, TH, Brefeldin A biosynthesis cluster protein Bref-TH.
What is the protein family that this protein belongs to?
Belongs to the polyketide transferase af380 family.
Protein: SELA_YERPP
Sequence: MSAEPHPLYRQLPAIDRLLNEPEMAPLLAEYGPVLLADTLRQLQAEAREYIGQFHTLADWCADWPAALRQRLNQRQPALKPVFNLTGTVLHTNLGRAPLAESAIAAVTDAMRSAVTLEYSLEGAGRGHRDRAVADLLCALTGAEDACIVNNNAAAVFLLLTVMAAGKQVVVSRGELVEIGGAFRIPDVMRQAGCELVEVGTTNRTHLKDYRQAINENTGLLMKVHTSNYSIEGFTAAVSEQQLAALGQECSIPTATDLGSGSLVDMTRYGLPAEPMPQQLIAAGVDLVTFSGDKLLGGPQAGIILGKKQWIERLQQHPLKRALRADKMTLAALDATLRLYQQPDRLVEQLPSLRLLTRPASEIAACAQRLLAPLIACYGTDFTLDIESCWSQIGSGSLPVDRLPSWALTFTPKDGRGSTLEALTARWRTLTKPVIGRVADGRLWLDLRCLEDEAALLRELAS
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADH1_ALLMI
Sequence: STAGKVIKCKAAITWEIKKPFSIEEIEVAPPKAHEVRIKILATGICRSDDHVTAGLLTMPLPMILGHEAAGVVESTGEGVTSLKPGDKVIPLFVPQCGECMPCLKSNGNLCIRNDLGSPSGLMADGTSRFTCKGKDIHHFIGTSTFTEYTVVHETAVARIDAAAPLEKVCLIGCGFSTGYGAAVKDAKVEPGSTCAVFGLGGVGLSTIMGCKAAGASRIIGIDINKDKFAKAKELGATECINPLDCKKPIQEVLSEMTGGGVDYSFEVIGRIDTMTAALACCQDNYGTSVIVGVPPASEKITFNPMMLFTGRTWKGSVFGGWKSKESVPKLVADYMEKKINLDGLITHTLPFDKINEGFELLRTGKSIRSVLTF
What are the official names of this protein?
Alcohol dehydrogenase 1, Alcohol dehydrogenase, major.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_TROWT
Sequence: MARVAGVDIPGNKRVEIGLTYICGIGPTRSRHALTAAGISFDTRVKDLTDDQLVALRAHIQNSYRIEGDLRREVASDIRRKVEIGCYQGLRHRRGLPVNGQRTRTNARSSKGPRRTVAGKKKAR
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: CHM2B_DANRE
Sequence: MTSLFKKKTVDDVIKEQNKELRGTQRQIARDRTALEKQEKQLEMEIKKMAKTGNRDACKVLAKQLVQVRKQKTRTYAVSSKVTSMSTQTKLMNSQMKMAGAMATTTKTMQAVNKKMDPKKTMQTLQNFQKETAKMDMTEEMMNDTLDEIFEDSGDEEESQDIVNQVLDEIGIEISGKMAHAPSAARKTPSAATAKADGISDEDIERQLKALGVD
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 2b, Chromatin-modifying protein 2b, CHMP2b.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein.
Protein: NS1AB_TASV2
Sequence: MAQAGRSGDAFASLDQRRERQEEQAQSGLDKVFYFQGVVELFNRMKIAYGRTPAWTALMKCNAIYLKDFKTAVGVEGTRYGLFFAEEVTKPTWSPDIGANLITLGEKACLDAQNAKYERLQASLKTTSGLVHQVMEKTREAKENLEKANKIQEQLDKVIESNKALHRKIQERNREKMQEYMVRLHNTQKDRDDWVQRCSRLEQENVTLQKRLKEKENALVSVGWDLLGWIVISVLVFGLISLADAQNLTPPAKIVITPGQAEFMDLAKLEKIQVRKYRLDSCELPPEKGCVLYKDYLTTRPVSFLELMAKCSKPDWVSESSYNETTLMEECIQIFGAEWCEGKLVDLVPRKCGEQHVLVNIIEQIEKTREVVTLIYGKVMSYRLDMWITSIFSLVLAGNKEKLFKMAPFIFVAWFLNIPVFLTCVAVNIFPVVSLPFILFQIFMPQFVLVNAFLLWLTLTLTAFYWSEGPKILMEISYALVYTIGFVLWSLGLAVGVTLKLTMVHQILMFCVVAAAICGTKFACTTITVQHPDGTTAKYTRVGKLKNNVVNQCKKVVTTLQTRGVIPATPAKTASIVIVEGKNGTGVGFRFMNYILTAEHVVQGSDIATLKNGSVSVKSKVIKTIPIFESVDNVAVLKLPPELNSVKPIKLAKKVQSDYLTLTAYDPNFQHAATFTGWCIIDGNWLNNSFDTKFGNSGAPYCDHDGRLVGIHLGTQGVLSQGIVIVDALKNTFQLADQCRPQNFDMDEFLEKVIAGTKVSHAAILKELEELREEVQFLKKKCVTYDDYWLCQTIFGQAKGKTKKTVRGRKHLVTKRALGKGHFMKMRMLTDEEYQNMIEKGFSAEEIREAVNALREQAWLNYCIDNDVDDEGEEDWYDDMVETDRVNQEIDEAIERAMEDRGEFYQKKSRLTFVEQAMMHLIQVSKERSQTAKLEVQKENEAQLVKMFERCVTDENTPEGTTSIAALSTEDDVRLVEGKVIDFTKAKNIPVDGEIRREIIPGTKCTEISTGPENKKNILKKKDTHIAEGKVETKSSQQPVDVKDDKPVALEQRKPRACKWCGSSQKHDYRECRFQREKRFCVYCAAMHSMFEGHIRPIECTSCKKSFSGIEKLEDHVVSGECQKKLIEGPVTTKAPTPVPDWLKIFAWEDDILPPEGKTALPENVTLIGHIPVDKLVSRTKKVQDPLLGLVTPWKQDMYDSTTWTVKAYTKMFEKFHYHDPVDFVEQYAEFVLLCDNMVLREHDYMANSNITPIMSTEKNVNSTPAYPKFQAYDSEAEYLEDCGWQEYLDVVSDPETINRRPLWWCFLKNEVLKREKIEDSDIRMILCTDPIFTRIGAMFEQDQNNRMKQQTEIRSAQVGWTPFFGGLDRRVRRLYGDGDRYFVEMDWTRYDGTIPKSLFWRIRQIRFFFLHDSHKTPKMRRLYNWYVKNLLEKIILLPTGEVCQVKKGNPSGQFSTTVDNNMINVWLTTFEVSYLFFKQRGRLPTEKELQENCSMICYGDDRLLSIRKGFVEYEPDTVIDMYKNIFGMWVKRNNIKIQDTPEGLSFCGLTIVKSSTGAYVGVPNVNKILSTLENPVRRLPDVESLWGKLVSLRILCENAPSNVKHFLDEQISNVEEFAARENIQLPEVGPDFYSRIW
What is the function of this protein?
Protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.
What are the official names of this protein?
Non-structural polyprotein 1AB.
What is the protein family that this protein belongs to?
Belongs to the astroviridae polyprotein 1AB family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: ERPA_YERPB
Sequence: MSNETVLPLQFTEAAAKKVKLLISDEENPNLKLRVYITGGGCSGFQYGFTFDDQVNDGDMTIEKQGVELVVDPMSLQYLVGGAVDYTEGLEGSRFIVTNPNAKSTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: CLPX_LYSSC
Sequence: MFKFNDEKGNLKCSFCGKPQEQVRKLVAGPGVYICDECIELCSEIVVEELGVEEEIEFQDIPKPKEILTILDEYVIGQERAKKALAVAVYNHYKRINTNSKIDDVELAKSNIVLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDIERAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFLQIDTTNILFIVGGAFDGIESIIKRRQGEKIIGFGSDPNIVDVDEGSIMSKLIPEDLLKFGLIPEFIGRLPVLASLEQLNEAALVQILTEPKNALAKQYQKMLELDGVELEFDEGALAEIAKEAIERKTGARGLRSIIESTMLDVMYELPSREDVKKCIITAKTITDKEKPKLLLEDGTELDEGSDTKTSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RECX_BACCR
Sequence: MAVITKIEVQKRSKERFNIYIDKGQGEEYGFSVDQVILIKHGLQKGLEIDEIELGNILYNEEVQKAYLQAISYLSYQMRTKQEIEDFLRKKEVGQAIISEVVSKLLHDRYINDKEYAVLYTRTQSNVNRKGPTVIKRELLNKGVQDLIITHSLQEYPKEKQIENALFLIEKKKKSYQKHSFLQMKLKLDEMLVRKGYSREVIQICLEELKDEKDDEKQQEALHYHGNKYYEKYKKHDGWTFENKMKQALYRKGFSIDEIEIFLQMKREEE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SVOP_CAEEL
Sequence: MGDKAILTEVLEASNLTEAYVDLTAKQLIKEIRHVGDDFAVRYSNLDDRTELGEPTDQRSPDSEKTFTVDEAVEALGFGRFQLKLSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERALETLQAAARMNRVQLPTGRLVSSTKAGSESRGDIANLLSPDLRKTTILLWCIWAITAFSYYGMVLFTTVLFQSHDECHGGLFSNGTQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLSLPIGIYGTAAILGLIASLSLPIETKGRQMMDSH
What are the official names of this protein?
Putative transporter svop-1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DADD_METMA
Sequence: MADIIIKNAYVLTMDPDAGDIKKGTVVIEDGKITEIGVKTKESADTVIDAKGSVVMPGLVNTHTHAAMTLFRGYADDLQLAEWLEKHIWPAEAQLTAEDVYRGSLLACLEMIRSGTTSFADMYFFMDETAKAVEASGLRASLSHGLIELWNEEKGENDLKEGKRFVRAWQGAAKGRIKTMYGPHAPNTCSDEFLAKVKEAARQDGAGLHIHVLETEAELLAMKERYGKCSVHMLDDIGFFGPDVLAAHCVWLSDGDIEVLREKGVNVSHNPISNMKLASGTAPVYKMLERGVNVSLGTDGCASNNNLDLFEEMKTAALLHKLSTCNPTALPARQVLQMATVNGAKALGTETGMLKTGMKADMIIVDMKKPHLTPCFDVPSHLVYSAGGSDVRTTIVDGKILMQDYRVMVLDEQKVIEEAQKAAEELVARVNS
What is the function of this protein?
Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs.  Can also deaminate adenosine.  The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated.  Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions.  May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
What are the official names of this protein?
5'-deoxyadenosine deaminase, 5'-dA deaminase, 5'-methylthioadenosine deaminase, MTA deaminase, Adenosine deaminase, S-adenosylhomocysteine deaminase, SAH deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Protein: NDUB5_MOUSE
Sequence: MAAMSLLQRASVSALTALSCRRAGPRLGVGSFLTRSFPKTVAPVRHSGDHGKRLFVVKPSLYYDARFLRLMKFYLMLTGIPVIIGITLVNIFIGEAELAEIPEGYIPEHWEYYKHPISRWIARNFYDGPEKNYEKTLAILQIESEKAELRLKEQEVRRLMRARGDGPWYQFPTPEKEFIDHSPKATPDN
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial, Complex I-SGDH, CI-SGDH, NADH-ubiquinone oxidoreductase SGDH subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFB5 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: QUEA_SALPC
Sequence: MRVTDFSFELPDSLIAHYPQPERSRCRLLSLEGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGTELLLGDDESIHATMTARHGALFEVEFNDPRPVLDILNAIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLAALREKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQEVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKSDLIEPFFGDTQIFIYPGYQYKVIDALITNFHLPESTLIMLVSAFAGYQHTMNAYKTAVEQKYRFFSYGDAMFITYNPQAISERP
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP415_ARATH
Sequence: MTSPSTSKNHRCLNLISKCKSLQNLKQIHAQIITIGLSHHTYPLSKLLHLSSTVCLSYALSILRQIPNPSVFLYNTLISSIVSNHNSTQTHLAFSLYDQILSSRSNFVRPNEFTYPSLFKASGFDAQWHRHGRALHAHVLKFLEPVNHDRFVQAALVGFYANCGKLREARSLFERIREPDLATWNTLLAAYANSEEIDSDEEVLLLFMRMQVRPNELSLVALIKSCANLGEFVRGVWAHVYVLKNNLTLNQFVGTSLIDLYSKCGCLSFARKVFDEMSQRDVSCYNAMIRGLAVHGFGQEGIELYKSLISQGLVPDSATFVVTISACSHSGLVDEGLQIFNSMKAVYGIEPKVEHYGCLVDLLGRSGRLEEAEECIKKMPVKPNATLWRSFLGSSQTHGDFERGEIALKHLLGLEFENSGNYVLLSNIYAGVNRWTDVEKTRELMKDHRVNKSPGISTLN
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At5g43790.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
Protein: VE1_HPV14
Sequence: MADPKGSTSKDGLDDWCIVEAECSDIENDLEELFDRDTDSDISELLDDNDDLDQGNSRELFHQQESKESEEHLQKLKRKYLSPQAIAQLSPRLESITLSPQQKSKRRLFAEQDSGLELTLTNEAEDVSSEVEVPALDSQPVAEAQIGTVDIHYTELLRASNNKAILMAKFKEAFGVGFNDLTRQFKSYKTCCNHWVLSVYAVHDDLLESSKKLLQQHCDYVWIRGIAAMSLFLLCFKVGKNRGTVHKLMTSMLNVHEKQILSEPPKLRNVAAALFWYKGAMGSGTFTYGPYPDWMAHQTIVGHQSTEANAFDMSVMVQWAFDNNYLDEADIAYQYAKLAPEDSNAVAWLAHNNQARFVRECASMVRFYKKGQMKEMSMSEWIHTRITEVEGEGHWSTIAKFLRYQQVNFIMFLAALKDMLHSVPKRNCILIYGPPNTGKSAFTMSLIRVLRGRVLSFVNSKSQFWLQPMSECKIALIDDVTDPCWLYMDTYLRNGLDGHYVSLDCKHKAPIQTKFPALLLTSNINVHNEITYRYLHSRIKGFEFPNPFPMKADNTPEFELTDQSWKSFFTRLWNQLELSDQEDEGDNGESQRPFQCSARSANEHL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: CSRA_PSEAE
Sequence: MLILTRRVGETLMVGDDVTVTVLGVKGNQVRIGVNAPKEVAVHREEIYQRIQKEKDQEPNH
What is the function of this protein?
Probably binds to and is sequestered by non-coding small RNA (sRNA) RsmZ; overexpression of rsmZ produces very similar phenotypes to deletion of rsmA, while rsmZ deletion has no phenotype (PubMed:15126453).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator, Global translational regulatory protein RsmA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHLB_XANOR
Sequence: MSDKPLTDVTFSSFDLHPALVAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLNRPALADRKPEDPRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEADRMFDLGFIKDIRFLLRRMPERGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPSDDEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQKIPVEPVTSELLTPLPRAARVPVEGEEADDEAGDSVGTIFREAREQRAAEEQRRGGGRSGPGGGSRSGSGGGRRDGASAGADGKPRPRRKPRVEGEAPAAAAQTEKPVVAAAAAQAPSVGMADAERAPRKRRRRRNGRPVEGAEPAVASTPIAAPAAPRKPTQVVATPVRAANKSSGSPSLLGRIGRRLRSLVSGN
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOG_SHIFL
Sequence: MATIHVDGKEYEVNGADNLLEACLSLGLDIPYFCWHPALGSVGACRQCAVKQYQNAEDTRGRLVMSCMTPASDGTFISIDDEEAKQFRESVVEWLMTNHPHDCPVCEEGGNCHLQDMTVMTGHSFRRYRFTKRTHRNQDLGPFISHEMNRCIACYRCVRYYKDYADGTDLGVYGAHDNVYFGRPEDGTLESEFSGNLVEICPTGVFTDKTHSERYNRKWDMQFAPSICQQCSIGCNISPGERYGELRRIENRYNGTVNHYFLCDRGRFGYGYVNLKDRPRQPVQRRGDDFITLNAEQAMQGAADILRQSKKVIGIGSPRASVESNFALRELVGEENFYTGIAHGEQERLQLALKVLREGGIYTPALREIESYDAVLVLGEDVTQTGARVALAVRQAVKGKAREMAAAQKVADWQIAAILNIGQRAKHPLFVTNVDDTRLDDIAAWTYRAPVEDQARLGFAIAHALDNSAPAVDGIEPELQNKIDVIVQALAGAKKPLIISGTNAGSIEVIQAAANVAKALKGRGADVGITMIARSVNSMGLGIMGGGSLEEALTELETGRADAVVVLENDLHRYASATRVNAALAKAPLVMVVDHQRTAIMENAHLVLSSASFAESDGTVINNEGRAQRFFQVYDPAYYDSKTVMLESWRWLHSLHSTLLSREVDWTQLDHVIDAVVAKIPELAGIKDAAPDATFRIRGQKLAREPHRYSGRTAMRANISVHEPRQPQDIDTMFTFSMEGNNQPTAHRSQVPFAWAPGWNSPQAWNKFQDEVGGKLRFGDPGVRLFETSENGLDYFTSVPARFQPQDGKWRIAPYYHLFGSDELSQRAPVFQSRMPQPYIKLNPADAAKLGVNAGTRVSFSYDGNTVTLPVEIAEGLTAGQVGLPMGMSGIAPVLAGAHLEDLKEAQQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit G, NADH dehydrogenase I subunit G, NDH-1 subunit G.
What is the protein family that this protein belongs to?
Belongs to the complex I 75 kDa subunit family.
Protein: H2A2_LILLO
Sequence: MISSANNKGAGTSRRKLRSEKAALQFSVSRVEYSLKKGRYCRRLGATAPVYLAAVLENLVAEVLEMAANVTEKHKRIVIKPRHIMLAVRNDVEVNKLFHGVTISASGVVPKTRKELDRRKRRSTSQAD
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  May be involved in the repression of gene expression in male gametes.
What are the official names of this protein?
Histone H2A.2, GH2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SP2AA_WEICA
Sequence: MSLAIDLEVKKDVLCIRLQGELDHHTAESLRASVTKAIEENGIRHLVLNLEQLSFMDSSGLGVILGRYKQIKQKNGEMIVCAISPAVKRLFELSGLFKIIRLDESEQYALHRLGVA
What is the function of this protein?
In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.
What are the official names of this protein?
Anti-sigma F factor antagonist, Stage II sporulation protein AA.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor antagonist family.
Protein: IL5_SHEEP
Sequence: MHLRLTLVALGAAYVCANAVESTMNRLVAETLTLLSTHQTLLIGDGNLMIPTPQHTNHQLCIEEVFQGIDTLKNQTAQGDAVKKIFRNLSLIKEYIDLQKRKCGGERWRVKQFLDYLQVFLGVINTEWTMES
What is the function of this protein?
Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils.  Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity).  Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB.  Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
What are the official names of this protein?
Interleukin-5, IL-5, Eosinophil differentiation factor, T-cell replacing factor, TRF.
What is the protein family that this protein belongs to?
Belongs to the IL-5 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PDRP1_LISMF
Sequence: MTQPAVYVVSDSTGETAELVTRAALSQFGQTPKFIHRFHHVDSSHMIEEIVDLVAVNNGIIVHTIVLESVREELNKTAQAFGVPIIDLFGPLLNQLEETYKIKPLSEPGRVRSMDEAYFNKVAAIEFAVENDDGRNPRGILQADYVLIGISRTSKTPLSQYLALKGLKIVNIPIVPEAQIPDELFEIDPKKIIGLKISKQKLTKIRQERLISIGLPGAGTYASNQRIDEELAIFNKLASKLNCFVLDVTNKAIEETANEILIHIGEIVDENLEL
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein 1, PPDK regulatory protein 1.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: YY1A_XYLFA
Sequence: MRYTFGIVTVYLLAGCAGSPPKPPEVKGKYRPINRVEAPASAGRNPVNSLNALCGNLNEKQCR
What are the official names of this protein?
Putative conjugal transfer lipoprotein XF_a0011.1.
What is the protein family that this protein belongs to?
To B.suis ORF12 in VirB region.
What are the subcellular locations of this protein?
Cell inner membrane; Lipid-anchor.
Protein: ZN138_HUMAN
Sequence: MKRHEMVVAKHSALCSRFAQDLWLEQNIKDSFQKVTLSRYGKYGHKNLQLRKGCKSVDECKGHQGGFNGLNQCLKITTSKIFQCNKYVKVMHKFSNSNRHKIRHTENKHFRCKECDKSLCMLSRLTQHKKIHTRENFYKCEECGKTFNWSTNLSKPKKIHTGEKPYKCEVCGKAFHQSSILTKHKIIRTGEKPYKCAHCGKAFKQSSHLTRHKIIHTEEKPYKCEQCGKVFKQSPTLTKHQIIYTGEEPYKCEECGKAFNLS
What is the function of this protein?
May be involved in transcriptional regulation as a repressor.
What are the official names of this protein?
Zinc finger protein 138.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.