PharMolix/UniProtQA huggingface dataset:
Protein: MUP11_MOUSE
Sequence: MKMLLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE
What is the function of this protein?
Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks.  May protect pheromones from oxidation.  May also act as pheromones themselves.  In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (Probable).  Binds the pheromone analog 2-sec-butyl-4,5-dihydrothiazole (SBT) in vitro (PubMed:25279835).
What are the official names of this protein?
Major urinary protein 11.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPSC_THYCA
Sequence: MSTISIHHVGILRNPLHSKSKRASINKPWSLSLPRSSSASRLVEPCRVSSKTDTKPAEITRRSGNYEPSLWDFDFIQSLDNHHPYVKEEQLKREEELIVQVKILLGTKMEAVKQLELIDDLKNLGLSYFFRDEIKTILTSIYNNSFENKNNQVGDLYFTSLGFRLLRQHGFNVSQDIFDCFKNEKGSDFDETLIGEDTKATLQLYEASFHLREGENTLELARQISTKYLQKKVNEGRISDENLSSWIRHSLDLPLHWRIQRLEARWFLDAYAVREDKNPLIFELAKLDFNIIQATQQEELKEVSRGWNDSCLAEKLPFVRDRVVESYFWGVGLFEGHEFGYQRKLTAANTLLISAIDDVYDVYGTLDELRLFTDVFRRWDTESIDQLPYYMQLCYLALYNYVSGVAYDILKDHRRNTIPYLQETWVELVEAYMKEAEWYKSGYTPSLEEYLTIAKISIASLTILLSVELSLPDSTIDRATFDRRHKMFYLSATVSRLADDLGTAPSELERGDVPKAIQCYMKDTNASEEEARGHVRFMIGETWKELNTAMAKPDDCPFTEQVVEATANLGRAAQFIYREGDGHGHFQIHQHMGNLFFHPYV
What is the function of this protein?
Involved in the biosynthesis of phenolic monoterpenes natural products (PubMed:23624978).  Monoterpene synthase which catalyzes the conversion of geranyl diphosphate (GPP) to alpha-terpineol (isomer is not determined) (PubMed:23624978).
What are the official names of this protein?
Alpha-terpineol synthase, chloroplastic, Terpene synthase 5, TcTPS5.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KIRR2_HUMAN
Sequence: MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEEGTLETKDPTNGYYKVRGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPTFYDFNPHLGMVPPCRLYRARAGYLTTPHPRAFTSYIKPTSFGPPDLAPGTPPFPYAAFPTPSHPRLQTHV
What is the function of this protein?
May regulate basal insulin secretion.
What are the official names of this protein?
Kin of IRRE-like protein 2, Kin of irregular chiasm-like protein 2, Nephrin-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta- catenin.
Protein: SYE_PROM0
Sequence: MEKRLRLAPSPTGLFHIGTARTALFNWLYAQKIGGKFLIRIEDTDFLRSKSEYTKNILEGLKWLGLKWDEEPIKQSDRISIHKSYIKKLLECGAAYRCFTSEDEISELREEQKKKGLPPKHDNRHRSLSKEEIETFISQGRTSVIRFKIDEKIEIKWIDQIRGEIKWQGKDLGGDLVLSRRAKGYEIGDPLYNLAVVVDDNFMNITHVVRGEDHISNTAKQILIYKALNFNLPTFSHTPLILNSEGKKLSKRDCVTSIDEFREMGYLPEALSNYMAFLGWSPKSADREILSLEEISKIFDLSEINKAGAKFSWEKLNWINSQYIKNIESIKLIEIMRKYWDDNGWKPPSEEWANKLAILIRDSMTLLKDSIDQSKPFFLIPTIQKEGQDFLEIRESKLSLKLILNYLIEKNTIKLNKEKAKEIINEISKKHNIKKGILMKSLRVAFFGSLSGPDLIQSWELFAESKTDRTRIERCL
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_CUTAK
Sequence: MTMTDPIADMLTRLRNANQAYHDQTSMPHSKIKAGIAGILKSEGYIADYKVNEPKEGEVGKTLTLTLKYGENRERSIAGVRRISKPGLRVYAKSTALPKVLGGLGIAIISTSQGLLTDKQAHEKSVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: FADR_SHIB3
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR
What is the function of this protein?
Multifunctional regulator of fatty acid metabolism.
What are the official names of this protein?
Fatty acid metabolism regulator protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODO2_MOUSE
Sequence: MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCRGPGYPDNRKMVINSGSVFRVRFFQTTAVCKNDVITVQTPAFAESVTEGDVRWEKAVGDAVAEDEVVCEIETDKTSVQVPSPANGIIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAETPAPAHKAEPAAPAAPPPPAAPVLTQMPPVPSPSQPPSSKPVSAIKPTAAPPLAEAGAAKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEVDMSNIQEMRARHKDAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDATKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYADIERTINELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHAIFDRPVAVGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
What is the function of this protein?
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity).  The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity).  The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion.  A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, E2K.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein: HSLO_AERS4
Sequence: MSNQDLLYRYLFEEYEVRGELVQLDHTYRHVVEAQSYPVQVQKLLGELLVATSLLTATLKFEGSITVQLQGDGPVRLAVINGDNNQQLRGVARYEGELPSDGKLQSLIGNGQLIITITPEQGERYQGIIALDADTLAGCLEHYFAQSEQLATKLWIRTGYHQGEPRAAGILLQALPAQSEDHSADFDHLTQLTATIKDEELFGLEAEEILYRLYHQDKVRVFDPQAVEFRCTCSRARCEGALLQIEKEEVLDMVQELGKIDMHCDYCGAQYQFDGIDVETLFSRAPDNDANKLH
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMJ_SALTI
Sequence: MQICLMDETGATDGALSVLAARWGLEHDEDNPMALVLTPQHLELRKRDEPKLGGIFVDFVGGAMAHRRKFGGGRGEAVAKAVGIKGDYLPDVVDATAGLGRDAFVLASVGCRVRMLERNPVVAALLDDGLTRGYADADIGGWLQERLQLIHASSLTALTDITPRPQVVYLDPMFPHRQKSALVKKEMRVFQSLVGPDLDADGLLEPARQLATKRVVVKRPDYAPPLADVATPNAIVTKEHRFDIYAGTPLTE
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORFE_PSHV1
Sequence: MGDNSAALQLRVSPATRTPPQRYSKTRPQKAKYPVTTCANNFIASAHMNRGSSYWHSVTDFFSYQLAIIKGVVPSSAIGEDCGRSDSPTIIKVDLFDCGDASKPVFASARFYPASRAPEDLPPPTDLDRWAAATAVVVTRFPKRHDHRRADTPTPRSSSLTLAETLARHDKKAAAHWADAAATVARSRPMAFGDKFMGFELVGGHPWEDGIGLLLLGAVPFAELCPATSVVRAYSSSLLFSTCAAKSAILAETQMASCDDREDGNEAAQATFPVLTLGDPRMHHGLRVTATQPATAPLVFSFKEKMSFAAPLGAGLAESLIMPPSAISPKRVEARIINTCSISHHVTCAFFPVTGLDPTNDFAYLALDTWANRASSWLLESAEGRALFDKILEEVPVCGKFLCAAVKTACTDGPALGLMAHFHWAPENIKNFYSVAHAAIREAWVALRVSTVESLL
What are the official names of this protein?
Uncharacterized protein ORFE.
Protein: RSMH_RICAE
Sequence: MIQSHVSVMLNEMLEALSPKAGESYLDCTFGAGGYSKAILESCNCYVTALDRDPNVIKRAEEIQQSYGERFDFVETNFADSFAKLKEKKFDGIVLDLGVSSMQLDIADRGFSFLHNGPLDMRMSGQGLSAEEFVNAAEEKELADVIYKYGDESFSRRIAKRIVEYRKTARIDSTSKLAEIVRSSIGFRKGKIDPATKTFQAIRIYVNDELGELEQFLVNVKNILKKDGRLVVVSFHSLEDRIVKNFFKENSEKPVVRSKYAKDDMTIDPNKWLKIITNKALAPSDKEVGLNIRARSAKLRAAKAIYE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNFC_SALTI
Sequence: MKKPLLLTLLCMILAGCDNPKSPESFTPEMASFSNEFDFDPLRGPVKDFSQTLMSENGEVAKQVTGTLSQEGCFDTLELHDLENNTGLALVLDANYYRDAQTLEKKVQLQGKCQLAALPSAGVTWETDDNGFVVSATGKEMKVEYRYDSEGYPLGKTTINSQNTLSVTAKLSTDSRKKLDYTAVSRVDDRQVGNVTQSCEYDAYANPVDCRLVIVDESVKPAVSHHYTIKNRIDYY
What are the official names of this protein?
UPF0257 lipoprotein YnfC.
What is the protein family that this protein belongs to?
Belongs to the UPF0257 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: SODM_STRSL
Sequence: YIDAETMTLHHDKHHATYVANANAALEKHPEIGEDLEALLADVEQIPADIRQALINNGGGHLNHALFWELLSPEKQEPTAEVAAAINEAFGSFEAFQEAFTAAATTRFGSGWAWLVVNDEGKLEVVSTANQDTPISDGKKPILAL
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.  Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.
What are the official names of this protein?
Superoxide dismutase [Mn/Fe].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: ESXE_MYCTU
Sequence: MDPTVLADAVARMAEFGRHVEELVAEIESLVTRLHVTWTGEGAAAHAEAQRHWAAGEAMMRQALAQLTAAGQSAHANYTGAMATNLGMWS
What are the official names of this protein?
ESAT-6-like protein EsxE.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. ESAT-6 subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX / type VII secretion system (T7SS).
Protein: Y723_DEIGD
Sequence: MPFVVVSGLSGSGKSTALRTLEDAGFFITDNLPPELWGAMHDLATARGLERVAVSTDARTRFFLGALEDSYLRLSRRREDLRVLFLEATSEVLLRRYNLTRREHPLGETLLVDFARERELLAPLRALADIVIDTTDLTAAELSQKVLQMLRLEQDFHLRLLSFGFKHAPPRDADLVIDVRSLPNPYYVPELRPRTGLEPAVAGYVFRDEASEQFYREVRDFVRLAAGRARAAGRHGYTVAIGCTGGQHRSVAVAERLAADLTDLGAQVTDHRDMQVGEGG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Dgeo_0723.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: PFKAM_RABIT
Sequence: MTHEEHHAARTLGVGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITAEEATRSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRITEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDNWEDHLCRRLSETRTRGSRLNIIIVAEGAIDRNGKPITSEGVKDLVVRRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAMKLRGRSFMNNWEVYKLLAHIRPPAPKSGSYTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGPAKGQIEEAGWSYVGGWTGQGGSKLGSKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMAGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELQNQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSEHAHLEHISRKRSGEATV
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, muscle type, ATP-PFK, PFK-M, 6-phosphofructokinase type A, Phosphofructo-1-kinase isozyme A, PFK-A, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTR18_CAEEL
Sequence: MKSISQCLGNVSLWIEQQTHDMFYWVGLKIADYPKWTLFITTIWALLMAGGVVRFKEVNNVRDHFSATNSPSRYEYRVAREFFQELGSPFHVVVAMQAADGGSLLRPKYIDKALEIEDFLQYKLKGSFGNQSYSYSDFCGTQCETSDAVSIFLSMFRDQQIKKTAHVKLTYPSMDVFGHRVYLANNIFQVKINNRSSIIEESKLVAINFHAIYNNETMYEIMKEWEQKLFAYTLSTENDPLIRVYVTSEGLVSEEVRRTGILAMPLMGVTFLIILAFTILTTLKRDPVKSKPFEAFLGVICPILSLCASFGHLFWMGFEYLPIVTVVPFLILSIGVDDVFIFIHAWHRTPYKHSVRDRMAETLADAGPSISITSLTNLLSFAIGIFTPTPAIYTFCVFISTAVIYDYIYQIFFFSAVLVLSGEREEQRKNAYLWWKDVPLPEEPTGKQKKETIVSRVLGKVLDFWVDFIMAKWSKFLIGAIMITYWIFMARGVMEIAVGLSSEKLFLDDSPLLPLVRLQTNVIFKEGGQVAVFVNNPGNMSEPDAVPEIMRILRRFEVANNSVGAASTHMWLLPYLPYVGEQEHGSIEFKYRYLPEFFKLTEFRRWSHFVNLGNHQDCLSEKPSCLQKFVFSTGFHDAVSWSDRLALLENWREMASEYQHLNLTIYEDFSMYSDQLLTIVPVTQSTVFCALICMIMILTLFTPSPVTIVTSTAAVLSINLGVFGCLVYMNIDLDPISMTTLLMAIGFSVDFVAHITWHYYKGDFHSKRARIRHALAGIAWPMFQAGTSTMLAITVLALVHAYMVQVFVKVVVLVIFLGMFHGLVVLPIVFSALPFTKTSGPQKKKVAPLQMHEAGPIPKKEEPKVIKVNGEEDEEDEKTTKEEPVEKSVRSAERA
What is the function of this protein?
Transporter, which promotes the endocytosis-mediated degradation of hedgehog-related proteins such as grl-7 in order to establish the capacity of progenitor cells to maintain quiescence in arrested L1 stage larvae.
What are the official names of this protein?
Patched-related protein 18, Patched domain-containing protein 18.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical cell membrane during the 3- fold stage during embryogenesis.
Protein: ISPF_SHIFL
Sequence: MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RAMB_CORGL
Sequence: MGKTYVGSRLRQLRRERDLSQASLAATLGLSASYVNQIEHDVRPLTVPVLLRITEAFGVDATFFSRDDDSRLLAEVQDVMLDREINPANVELQELSEMVYNHPQLARAMVEMHQRYRNVRDKFSIAVDNRTNTPEERRPIAEAVSMPHEEVRDFIYARQNYFDALDRRAEAIAAQLGWQPYDSRAMEDSIARRLQMDHDVTITSSKEESGTLHHFDPETRLLTIHARLNPGQRAFRMATELGYLEANDLIEGIVDDGIWSTPEARTLAIRGVASYFAAAVMLPYKIFHSEAEKSGYDIEYLGQLFGVGYETTAHRLSTLQRPNLRGIPFTFVRVDRAGNMSKRQSATGFHFTHYGGTCPLWNVFETFTNPGQVLRQFAQMPDGRNYLWISRTVRHHEARFGEVDKMFAIGLGCEARHADRTVYSRGFNLQDLSTATPIGSGCRVCTRENCAQRAFPSVHGRINIDAHESTIAPY
What is the function of this protein?
During growth on glucose, RamB negatively controls the expression of aceA, aceB, ack and pta genes which are involved in acetate metabolism (PubMed:15090522, PubMed:17114251).  RamB is also a negative regulator of rpf2 gene expression during growth on acetate as the sole carbon source (PubMed:18355281).
What are the official names of this protein?
HTH-type transcriptional regulator RamB, Regulator of acetate metabolism B, RamB.
What is the protein family that this protein belongs to?
Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.
Protein: RUVB_ESCF3
Sequence: MIEADRLISAGTTLPEDVADRAIRPKLLEEYVGQPQVRSQMEIFIKAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQYIVSRSARFMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGTISADIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATVRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RR12_PHYPA
Sequence: MPTIQQLIRNRRQPIENRTKSPALRGCPQRRGVCTRVYTVTPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSKYGVKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: WNT2_DROME
Sequence: MWKIHNKLLIYILWIMEIRLVSSFTSVMLCGRIPGLTPGQRNMCREMPDALIALGEGHQLGAQECQHQFRGHRWNCSEVWQRNVFAHVIPTASREAAYTYAIASAGAAYAVTAACARGNISTCGCDVRHKATPTGGGTPDEPWKWGGCSADVDFGMRYARRFMDARELERDSRTLMNLHNNRAGRTLVKKMLRTDCKCHGVSGSCVMKTCWKSLPPFRLVGDRLMLKYQKAKTVQAVKGKRGLRLVLSRKKHAGTARAQKPVLDWPKRMELIYLEASPNYCERSLQTGSQGTSGRTCQRTGHGPQSCDLLCCGRGHNTQHIRRTTQCRCQFRWCCEVKCDECDESYEEFTCK
What is the function of this protein?
Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus.  Segment polarity protein.  May function in gonadogenesis and limb development.  Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation.
What are the official names of this protein?
Protein Wnt-2, dWnt-2.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PTI1_SOLLC
Sequence: MSCFSCCDDDDMHRATDNGPFMAHNSAGNNGGQRATESAQRETQTVNIQPIAVPSIAVDELKDITDNFGSKALIGEGSYGRVYHGVLKSGRAAAIKKLDSSKQPDREFLAQVSMVSRLKDENVVELLGYCVDGGFRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWAQRVKIAVGAAKGLEYLHEKAQPHIIHRDIKSSNILLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLSSKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSLVTWATPRLSEDKVKQCVDARLNTDYPPKAIAKMAAVAALCVQYEADFRPNMSIVVKALQPLLPRPVPS
What is the function of this protein?
A serine-threonine kinase involved in the hypersensitive response (HR)-mediated signaling cascade.
What are the official names of this protein?
Pto-interacting protein 1, Pti1, Pto kinase interactor 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: RS7_RIPO1
Sequence: MSRRGNIKRRPVPPDPVYNSRLISMTIRRVMKSGKKSVAAGIMYDALTSIGEKTGSDPLEVFEKAIKNLTPLVEVKARRVGGATYQVPMEVRSSRGTTLALRWLVHYARIRGGRTMSSKLANEIMDAANETGGAMKKRDETHRMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: COX2_GERRO
Sequence: MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISSLVLYLISLMLSTKLIHTSTMDAQEVETIWTILPAIILIMIALPSLRILYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTNELKPGELRLLEVDNRVILPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVMSNRPGIFYGQCSEICGSNHSFMPIVLEMIPLKLFENWSISMS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.