PharMolix/UniProtQA huggingface dataset:
Protein: EID2_HUMAN
Sequence: MSKLPADSSVPQTGAANGDRDVPQAEVGRGRREPAPAQPEEAGEGAMAAARGGPVPAAREGRMAAARAAPAAAARGAPVAAAALARAAAAGRESPAAAAAREARMAEVARLLGEPVDEEGPEGRPRSRHGNGGLAALPYLRLRHPLSVLGINYQQFLRHYLENYPIAPGRIQELEERRRRFVEACRAREAAFDAEYQRNPHRVDLDILTFTIALTASEVINPLIEELGCDKFINRE
What is the function of this protein?
Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation.  Inhibits EP300 histone acetyltransferase activity.  Acts as a repressor of TGFB/SMAD transcriptional responses.  May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.
What are the official names of this protein?
EP300-interacting inhibitor of differentiation 2, EID-2, CREBBP/EP300 inhibitor 2, EID-1-like inhibitor of differentiation 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL2_HERA2
Sequence: MGIKRYKPTSPGRRGMTVSDFAEITKFEPEKSLTEPLKKHAGRNNHGHITTRHRGGGHKRRYRLIDFKRKKFDIPAKVAGIEYDPNRSANIALLHYTDGEKRYIIAPLGLKVGDTLMAGPNAEIRVGNALPLANIPIGSQIHNIELTPGRGGQLVRSAGNTAQLMAREGNYATVRLPSGEMRMVHIKCMATLGQVGNVDHQNIMIGKAGRSRWLGRRPVVRGSAMNPVDHPHGGGEGRAPTGMNPKTKWGKPAMGKKTRHNPRTQRFIVRTRKQK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MTLD_ECOL6
Sequence: MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVNAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAILDEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLPHKNLIEGIAAAMHFRSEDDPQAQELAALIADKGPQAALAQISGLDANSEVVSEAVTAYKAMQ
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: SYT_THET2
Sequence: MTVYLPDGKPLELPEGATAKDVARALGEGWERRAVGAIVDGELYDLLKPLPQGAKVRLLTEKDPEFQTLFRHTLAHVLAQAVKEFFREKGYDPESVRLGVGPVIEKGFYYDIEAPEPLSDEDLPAIEAKMREILKRDLPLRRFVLSREEALARYRGKDPYKTELILEIPEGEEISFYQQGDEAYGFTDLCRGPHVPSTGRIPPHFKLTHVAGAYWRGDENRPMLQRVYGVAFRTAEELKEYLWQLEEAKKRDHRRLGRELELFLIDPMVGKGLVLWLPKGNVVREELMAFMREEQVRRGYQLVTTPHIGSLELYKTSGHYPYYAESQFPPISFKERGEEEEYLLKPMNCPHHIRIYAYRKRSYRELPLRLAEFGTVYRYEKAGELLGLTRVRGFTQDDAHIFCTPEEVKGEFLGVLDLVLKVFATLGLKDYRARIGVRDPKSDKYVGDEAKWALAERQIEEAAAEAGLRYTVEEGDAAFYGPKLDFVVKDALGREWQLGTIQVDYNLPERFGLTYVGKDGEEHRPVMLHRAPFGSLERFIGILIEHFAGDFPLWLAPVQAVVVPVSEKQEGYAREVAGRLKEAGLRAEADTRPERMQARIRDAEVQKVPYVLVVGEREKAEGAVSVRRRKKGNLGTMPLAAFLEGALREYRERRLEPVF
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_NOSP7
Sequence: MAIISSKKQPPEPNGEPKQRRESAKAPSTENILKPEAAIDEQEQQEEGIRPHRFADYIGQKDLKDVLDIAIKAAKSRGEVLDHLLLYGPPGLGKTTMAMILASEMGVNYKITSAPALERPRDIVGLLVNMKPGDILFVDEIHRLSRMTEEILYPAMEDYRLDITIGKGSSARIRSLPLSKFTLVGATTRVGALTSPLRDRFGLIQKLRFYEVDELTQIVLRTAQLLKTPVTQDGATEIARRSRGTPRIANRLLKRVRDYAEVKVSGVINESIASEALQLFQVDPCGLDWTDRQMLSVIIEQFNGGPVGLETMAAATGEDTQTIEEVYEPYLMQIGYLTRTHRGRMATKAAYKHLGFTPPNEQLSLL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ETF1_VARV
Sequence: MNTGIIDLFDNHVDSIPTILPHQLATLDYLVRTIIDENRSVLLFHIMGSGKTIIALLFALIASRFKKVHILVPNINILKIFNYNMGVAMNLFNDEFIAENIFIHSTTSFYSLNYNDNVINYNGLSRYNNSIFIVDKAHNIFGNNTGELMTVIKNKNKIPFLLLSGSPITNTPNTLGHIIDLMSEETIDFGEIISRGKKVIQTLLNERGVNVLKDLLKGRISYYEMPDKDLPTIRYHGRKFLDTRVVYCHMSKLQERDYMITRRQLCYHEMFDKNMYNVSMAVLGQLNLMNNLDTLFQEQDKELYPNLKINNGVLYGEELVTLNISSKFKYFINRIQTLNGKHFIYFSNSTYGGLVIKYIMLSNGYSEYNGSQGTNPHMINGKPKTFAIVTSKMKSSLEDLLDVYNSPENDDGSQLMFLFSSNIMSESYTLKEVRHIWFMTIPDTFSQYNQILGRSIRKFSYVDISEPVNVYLLAAVYSDFNDEVTSLNDYTQDELINVLPFDIKKLLYLKFKTKETNRIYSILQEMSETYSLPPHPSIVKVLLGELVRQFFYNNSRIKYNDAKLLKMVTSVIKNKEDARNYIDDIVNGHFFVSNKVFDKSLLYKYENDIITVPFRLSYEPFVWGVNFRKEYNVVSSP
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from early gene promoters.  Is recruited by the RPO-associated protein of 94 kDa RAP94/OPG109 to form the early transcription complex, which also contains the core RNA polymerase.  ETF heterodimer binds to early gene promoters.
What are the official names of this protein?
Early transcription factor 70 kDa subunit, ATP-dependent helicase VETFS, ETF small subunit, VETF D6 subunit.
What is the protein family that this protein belongs to?
Belongs to the helicase family. VETF subfamily.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.
Protein: MDTG_ECO45
Sequence: MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQISN
What is the function of this protein?
Confers resistance to fosfomycin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtG.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OCCT_RHIRD
Sequence: MKLKTILCAALLLVAGQAAAQEKSITIATEGGYAPWNFSGPGGKLDGFEIDLANALCEKMKAKCQIVAQNWDGIMPSLTGKKYDAIMAAMSVTPKRQEVIGFSIPYAAGINGFAVMGDSKLAEMPGLGETYSLDSQADAAKKAIADISSFLNGTTVGVQGSTTASTFLDKYFKGSVDIKEYKSVEEHNLDLTSGRLDAVLANATVLAAAIEKPEMKGAKLVGPLFSGGEFGVVAVGLRKEDTALKADFDAAIKAASEDGTIKTLSLKWFKVDVTPQ
What is the function of this protein?
Component of the octopine active transport system probably consisting of four subunits: Q, M, P and T.
What are the official names of this protein?
Octopine-binding periplasmic protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS3_DICNV
Sequence: MGQKIHPIGFRLGVSKDWTSKWYAEGTDYANYLEKDFEVREFLRKKLAHASVSKIQIERPRNGAQITIFTARPGIVIGKKGEDIEILKKEVGKILGVATSINIEEIRRPELDSYLVADNIAKQLERRVMFRRAMKRAVASTMRLGAVGVKVSISGRLNGAEIARTEWYREGRVPLHTLRADIDYGLAEAYTTYGVIGVKVWIFKGENLEGLEADTSNTNELSDEKRNRRKPRNANRRKE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RL2_DEHMB
Sequence: MAIKIYRPTSPGRRHHSVSSFEEITKSRPERALLVSVKNDSGRNNQGRVTVRHRGGGSKTQIRVIDFKRNKLDVPGRVAAIEYDPNRTARIALVFYTDGEKRYILAPSDLKVGDVIMAGENAEPKSGNALPLSSIPTGTFIHNIEIIKGKGGIMVRSAGAAAQLMAKEDDYALVRLPSGEMRKVRSDCSATVGQIGNIEHGTLEIGKAGRNRHLGWRPTVRGSAMSPNNHPHGGGECRCPIGMTGPKTPWGKPALGYRTRKAKYSDKLIVKRRG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: LDHC_XENLA
Sequence: MSSVQENLITNVCQDKAAKPTNKITIVGVGQVGMACAVSVLLKELADELALVDILEDKLKGEVMDLQHGSLFLKTPTIVADKDYSVTANSRIVVVTGGVRQQEGESALNLVQRNVNVFKFIIPQVVKYSPDCIIIVVSNPVDILTYVTWKLSGLPQHRIIGSGTNLDSARFRHLISEKLGVHPSSCHGFILGEHGDTSVAVWSGVNVAGVSLQSLKPEIGTDQDSCNWKEVHKKVVDSAYEVIKLKGYTNWAIGFSVAEIVESITKNLGRVHPVSTMVKGMYGIETEVFLSLPCVLNGNGLTSVISQKLKDDEVGQLQKSSETLWGIQKDLQVL
What are the official names of this protein?
L-lactate dehydrogenase C chain, LDH-C.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSTB1_STRP3
Sequence: MTEPILQIRDLSVYYNQKKTLKDVSLDLYPNEITALIGPSGSGKSTLLRSINRMNDLNPEVTITGSIVYNGHNIYSPRTDTVDLRKEIGMVFQQPNPFPMSIYENVVYGLRLKGIRDKSILDHAVESSLKGASIWNEVKDRLHDSAVGLSGGQQQRVCIARVLATSPRIILLDEPTSALDPISAGKIEETLLLLKKDYTLAIVTRSMQQASRLSDRTGFFLEGDLLECGPTKAMFMNPKRKETEDYISGKFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MURI_ECODH
Sequence: MATKLQDGNTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRHLLPDLHYIYAFDNVAFPYGEKSEAFIVERVVAIVTAVQERYPLALAVVACNTASTVSLPALREKFDFPVVGVVPAIKPAARLTANGIVGLLATRGTVKRSYTHELIARFANECQIEMLGSAEMVELAEAKLHGEDVSLDALKRILRPWLRMKEPPDTVVLGCTHFPLLQEELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSADANIAFCMAMTPGAEQLLPVLQRYGFETLEKLAVLG
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: P7_BPPH6
Sequence: MTLYLVPPLDSADKELPALASKAGVTLLEIEFLHELWPHLSGGQIVIAALNANNLAILNRHMSTLLVELPVAVMAVPGASYRSDWNMIAHALPSEDWITLSNKMLKSGLLANDTVQGEKRSGAEPLSPNVYTDALSRLGIATAHAIPVEPEQPFDVDEVSA
What is the function of this protein?
Assembly protein part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them.  Required for efficient procapsid assembly.  Necessary for stable packaging.  May stabilize the RNA-dependent RNA polymerase (RdRP) in its position at the three-fold axis on the inner side of empty-unexpanded procapsids.  Could play a role in viral RNA recognition.  Seems to be involved in the regulation of plus strand synthesis (transcription) as a fidelity factor.
What are the official names of this protein?
Assembly protein P7.
What are the subcellular locations of this protein?
Virion. Note=Found in the capsid (Probable). Prior to RNA packaging, localizes on the inner procapsid surface near the three-fold axis of symmetry.
Protein: PSBB_MARPO
Sequence: MGLPWYRVHTVVLNDPGRLIAVHLMHTALVSGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITKSWGGWSITGETVTNAGIWSYEGVAAVHIVLSGLLFLAAIWHWVYWDLELFRDERTGKPSLDLPKIFGIHLFLSGVLCFAFGAFHVTGLFGPGIWISDPYGLTGKVQPVAPAWGAEGFDPFVPGGIASHHIAAGILGILAGLFHLSVRPPQRLYKGLRMGNVETVLSSSIAAVFFAAFVVAGTMWYGSAATPIELFGPTRYQWDQGFFQQEIDRRIRSSKAENLSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGAMDNGDGIAVGWLGHAVFKDKEGNELFVRRMPTFFETFPVVLVDEQGIVRADVPFRRAESKYSVEQVGVTVEFYGGELDGVSFSDPATVKKYARRAQLGEIFEFDRATLKSDGVFRSSPRGWFTFGHATFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFQKLGDPTTKRQVI
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: G3P_PYRAR
Sequence: MIRVGIVGFGTIGKRIADAVAAQGDMHVSGVLKVTPDYEVLVAAAKGFKVYTLPDRVEKFKKAGIEPAGTIEDLIKASDVIIDASPEDVGAENKEKYYSKFDKPVIFQGGEEAEVAEVSFNALANYDEARGRRYVRVVSCNTTGITRVLTSLMLNGVGIKKARIFIARRGADPKEYKKGPINDVVPNPATVPSHHGPDVKTVLKNVDIVTMAVAVPVTIMHMHMAFLELDGAYPRDAVLEALAKTPRIFLADVGAGFQSLAQIIEYARDLGRPRGDFPEVAIFRDSVTVNGNELYLMYGVHQESIVVPENVDAVRAVLGAMPKWESIKKTDTTLKLFTEGKRYG
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_CAMC1
Sequence: MNHFAKRIIPCLDVKDGRVVKGVNFVGLVDAGDPVEIAKRYNDEGADELCFLDITASHLGRDTIVDVVKKVASKLFIPLTVGGGIRTIDDISRLLNAGCDKVSLNSSAIKDPNLIDEAAKKFGSQCVVVAIDAKKIENGYSVFINGGRIDTKKDAFSWAKEVESRGAGEILLTSMDNDGVKQGFSLELTKIFSALSIPTIASGGAGKMEHFKDAFEVGADACLAASIFHFGEIEIKKLKEYLKANGVEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALT_CANAX
Sequence: MSEHKWWKEAVVYQIWPASYKDSNGDGVGDIPGIISTLDYIASLGVTTVWLSPMYDSPQDDMGYDVSDYENVYSKYGTLQDMDRLIAGCHDRGLKLILDLVINHTSVEHKWFKESRSSKDNPKRDWYIWKPPRIDSNGNKHPPNNWGSYFSGSAWKYDELTGEYYLHLFAESQPDLNWENKECREAIYNSAIKFWLDKGVDGFRIDTAGMYSKYQHFKDAPVAFPDTEFQPCEIYHKNGPRIHEFHKEMAKVMEPYDTMTVGEVGHSTREQALKYVSAAEKEMNMMFLFDVVELGSDPRDRFRYNGFDLVDLKKAIKSQGEFAEGTDAWSTVFIENHDQARAISRFGNDSPEFRVLSGKAIAMLQCCLTGTLFIYQGQEIGMTNVPRSWPIEEYKDINTINYYRAFKEKYGKDADYKQKEEKLVDVINRLARDNARTPVQWSHQQYAGFSEVEPWMRVNDNYKEINVEDQDGDDHSLLNFYRKLLKLRGEYKDLFVYGEMKFLDFDDKKLFTFAKEAPGSPVAYIVINFSGEDVKFEPLIKGNYKLVLTNVDKDSKDALSPYEARMYVVD
What are the official names of this protein?
Alpha-glucosidase, Maltase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: DAPB_MYCMM
Sequence: MRVGVLGAKGKVGATMVSAVESAADLTLSAEVDAGDPLSTLTETNTEAVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERVEQVQSWLAKKPSTAVLIAPNFAIGAVLSMHFAKQAAPFFDSAEIIELHHPQKADAPSGTATRTAKLIAEAREGLAPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTQGETLTIRHDSLDRTSFVPGVLLAVRRVRERPGLTIGIEPLLNLQ
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGR4_BOVIN
Sequence: MPGPLGLLCFLALGLRGSAEPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQLLDISMNNITQLPEDAFKNFPFLEELRLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSSLQSLRLDANHITSVPEDSFEGLTQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIKSLGQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELLFHSNSISVIPDGAFDGNPLLKTIHLYDNPLSFVGNSAFHNLSELHSLVIRGASMVQRFPNLTGTVRLESLTLTGTKISSISNNLCQEQKRLRTLDLSYNSIKDLPSFNGCHALEEISLQRNQIHQIKEDTFQGLTSLKILDLSRNLIHEIDDRAFAKLGSITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYTHSNTEDNSLQDHSGSKDKGLSDVAGVTSSAENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSVPSSKLFIGLISVSNLFMGAYTGILTFLDAVSWGRFAEFGIWWEIGSGCKIAGFLAVFSSESAIFLLMLAAVERSLSAKDMMKNGKSNHLRQFRIAALLAFLGAAVAGSFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDLSESSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAVSISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRHVSKKSGSASVSISSQAGCVEQDFYYDCGMYSHLQGNLTVCDCCEAFLLTKPVSCKHLIKSHSCPALTVGSCQRPDGYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD
What is the function of this protein?
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs.  Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal.  Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.  May also act as a receptor for norrin (NDP), such results however required additional confirmation in vivo.  Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells.  Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts.  Acts as a regulator of bone formation and remodeling.  Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state.  Involved in the development of the anterior segment of the eye.  Required during erythropoiesis.  Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production.  Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP.  Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity).
What are the official names of this protein?
Leucine-rich repeat-containing G-protein coupled receptor 4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MAMQ1_MAGSA
Sequence: MALGDANVGSAPGVDFSALQRVKQSEELLAQLYVVEETPRRLGRGPVHALMVISVLSVVAFIATLLMRYNTFVTMSEDTQAKRSNYEVMIQRRDNLFGNLVKLTLNHAALEHSIFSHTSDKRTEGVEAGKGGPIGSALEQLMKQGGIGKLLGDIGGGKALLGADGGFGNALGRLMAVVEQYPTIQSVDTYKHMMTSLVEMEDRIATRREDYNAAASTYNIEITKWPWNYLAFITGFKRAEYFQEKPAGDTPIITPQLFQELLPLNHAQDIKK
What is the function of this protein?
Essential for magnetosome formation (PubMed:20212111).  Can be used to induce magnetosome formation (PubMed:26884433).
What are the official names of this protein?
Magnetosome protein MamQ 1.
What is the protein family that this protein belongs to?
Belongs to the LemA family.
What are the subcellular locations of this protein?
Magnetosome membrane; Single-pass membrane protein.
Protein: GREB_PSESM
Sequence: MSTKIITQGGHEALKKELDYLWREHRPDITQKVAWAASLGDRSENADYQYNKKLLREIDRRVRYLRKRLEDMRVVQYSPEQEGRVFFGAWVEIENEAGDLKKFRVVGYDEIYGRNDYISIDSPMARALLKKEVGDEVLVNTPEGEKLWFVNSIVYER
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreB releases sequences of up to 9 nucleotides in length.
What are the official names of this protein?
Transcription elongation factor GreB, Transcript cleavage factor GreB.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family. GreB subfamily.
Protein: TPIS_RUBXD
Sequence: MAGERRPLMAANWKMNKTVREAQDYMAALLPRVADLAGEVDVAVFAPFTCLSEVARMAEGSGVLAGAQNFFYEDSGAYTGEVSAPMLLDVGARASIVGHSERRELFCETDESVARKARRAVEAGLLPVVCVGETEEERDAGRMWEKVSGQVRAVVEGLGDASGGRVVFAYEPIWAIGTGKTASPEDAQDAIGRIRGLLRELRGEGFAEEARLLYGGSIKPENISEIMAQKDVDGGLVGGASLEVGSFLQLVEAARG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGR_PROMH
Sequence: MRTPSKQEDLVKAFKALLKEEKFSSQGEIVTALQEAGFDNINQSKISRMLTKFGAVRTRNAKMEMVYCLPTELGVPTASSPLKNLVLDIDHNHSVVVIRTSPGAAQLIARLLDSLGKAEGILGSIAGDDTIFSTPAPGFSTEELRDAILNLFDQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_SHEPA
Sequence: MALWGGRFSQESSALFKLFNDSLPVDFRLIEQDIVGSIAWASAITQVGILTEKECTELHQALNELLAETQDSPELIIASGAEDIHSFVEQSLIAKVGDLGKKLHTGRSRNDQVATDLKLWCKKEGEQLLGLLANLRAALIGLAEREIDAVMPGYTHLQRAQPILFGHWCLAYVEMFERDISRLQDALKRADTCPLGTGALAGTAYPMDRVKLAKSLGFASPTLNSLDTVSDRDHVIEICSNASISMMHLSRMAEDLIFFNSGEAGFIELDDEVTSGSSLMPQKKNPDALELIRGKTGRVYGALMGILTTMKALPLAYNKDMQEDKEGLFDVMDSWSICLEMAALVLSGLQVNREKTLKAAKQGYANSTELADYLVAKGMPFREAHHVVGEAVVSAIAKQTPLEELTLVELQAFSAAIEADVYDCLTIESCLAKREALGGTSLSQVRNALATKKENC
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.