Protein: FNSA_PESFW
Sequence: MSQPTSVPKLLLHHAVESRDKVAFLGPGWSITYSDLEKRTRLVAAHLARAGIGRGDFVAIVLGRCLEAVESVLAIMRAGAVSVPLDPRSPPADLARVLEHSGARAIITDDRHLATVSAAAVKGSLIIISTTNAQVDVIESLKTERYQDWVEDDGYSTSDVHLDSLGDEEEAFLHYTSGTTSLPKGVLSSQKSALWNVEKVTSVFEFSSEDRFFWPLPLFHILGHSLCILATVAKGASAYLSDPDQLLLDNLLVKDVEDTTFIAGAPATFHELVEAKAASSSTLSLPKLRACMSAGAAASVSLCDQVHELFGVSLLNNYGCTETCGAIAISRPGHVYRQHGSVTPLPDWEIQLMDQDGKQVREGEQGELWVRGPGLMLGYYKETQSPFTEDAWFPTGDTGILTTSDVGKELSLVGRKKELIIRGGENIQPAELEQVLLQHPGVADVAVSGILHGLLGETPAAFIVKETPDLDLDLSSLIATCREALPDYKVPTAFYEIDAVPRTLLGKPKRLAVASYTSKPLTVRSRLQTRAAVEALVLAETAGACGVQAEPGEKESDPDWLRKYADESFSHLGLTSMAGVVLRDRLANLTGLVDLPNTLVFDYSTPAAVRDYLFNRLREQESPLPSKSAPALSLPSKAEPIAIISMACRYPGGISSPEDLWQLVSDEIDATTDFPSDRGWDIDSLYSTDPTEPFTSTTKRGGFLPDFADFDAGLFGMAPREALATDPQQRLLLETTWELAERGGIAPLSLKGTQTGCFIGTLYDDYEANGFGNAELEAHLGLGSSGSVMSGRISYYFGLHGPSIVISTGCSSSLCAVHSAAQALRNEECTLAIAGGITCMASPRPFTMFSKRRGLSADGRCRTYSSDAAGTGWSEGVGLIMLEKLSDAQRNGHRVLGVIRGSAVNSDGTSNGLTAPSGPAQQMCIQSALSQAALSPTDIDVLEGHGTATPLGDPIEVQAVINTYGNGSGNDPRANPLLIGSIKSNIGHTQAAAAVAGIIKMVKSIHHGVAPASLHIREPSRHIDWDGCGVEPLSKAKQWPSVDRARRAAVSSFGIGGTNAHIILEQPDSIEQNGVSTPKNHTIAFPWIISGADENALRAQAQSLLAAWRKSLSHESPSDIAFSLATARSSLKYRAVVTYTAGGDLNDQIETALTALAEDESHPDVVTGHTNTTGNKPRLACLFSGQGSRMPDPSAIEELSTVFPIFSRAFKEACEEVNQYLECPLERALSDSSLLDRTDFAQPALFVFEVAMYRLLESFDVIPDVVSGHSLGEIAAAHISGALTLRDAAIIVTTRSRLMAALDANGGMVSIAAPEQEVAEELSRLGSTAIIAVVNSEKSVVVSGTREAITAVADRFTELGRRTTILRNVNHGFHSPMMNGILGDLEEALASSIGSGTSSKIPLVSTVTGKLAEAAQLTSPQYWTRHVSEPVRFADSVNELRSNERVSVFIEVGPSAVLSPHVPGTVATYGTVGKLLNTLGQIWARGVPVNWQAVFGGVGAHLVDLPVYAFQRRKYWLPYRTLLPAESVGASGASSPGRTSDIGTSTLNHGVLYRTTSIAGTNDIICAGFVSASKQPWLRDHIISGQSLVPATAFAELALRAGRECADPSGSEQVILDELIILAPLALSLEEDDEEQEFEVQVVIKELEDEESTIRRSIDVYSRLHAVSTQPDWVQHATGTLKLISLPPPEKDVFTNGTHDVENSEVDVSKAYAMLEDFGISYGPAFQGVRGGWRQHDNELLVQINPPQDQDSKAGFVLHPALLDAALHAPILAAPEKVSSGQIRLPFSFKGIQVFEAATSTSGPVLARIRDLDDERFSVTITNKATGAAVAEISEVMLRAVQPPVVEGDLYRLKWTELKAAQTTKPNLVDDIFTVQAPRNVDAADIPKAVHNAVSEALRAIQQWRTKKANSSDKIRLIFVTEQASLHPDVNVIDAAVWGFVRSAQTEFGGENIILIDLDGSAESQEALPSAFDCGQEVVALQDGKIMVPTLSKEPPVPSTSTTLDVSGTVLITGGTGGLGAILSRHLVQTCGARNLLLTSRSGIKAAGATELLDELSAQDATVVRIESCDISDRAQLATLLEGNHGHPPITAIIHCAGVVDDGVLTSLTPERISRVLQAKVDAAWNLHQLAPETTRTFVLYSSFVGIVGNEGQAAYTAGNAFLNALARMRVAQGLPAVSLAWGPWANDVGMAAGDKLVIPNLRIASAQPVVDQQGLHLFDRALQTSEPVLVPLLLRGPFPMVPSAAAVTKSKKATAKGKAKTGAAWRKKLAAVSPESRSDTLLGLVRDEIAAVLGYQGQELPDGPLSDLGFDSFTSVTVSNRMRVLTGFRDLPVTLALDYDTPQALVQYLLDRINAEPETEIELDQDVAEEETVSGTNGHQNGHQNGTQNGHSNGHANGASTNGDATDGIDPEEFRGLSTLHRRLCRLEQYTAAADLLASAALAMPTFPSNGRKLLDYVADPHRLATGPEVSPGNDAPLPVVFIAPFFPRIKIGGISLSVYSAVAASLNGKRDVFELPHPEGQYVPEDLDTLAELHVSTIEQQFGDRPGIILAGYSAGGTVAYAVASKLAQAGKHPRLAGFVLVDTYLTMTGRGDPDWLNALPAEALVSRLGGPDSTGESLVGDLDLALAKVGGYFRTLRDWDQELYPLPDALSTLFVRALDPSEKMPKNADIWRPRWQRANHTVEVPGSHLALLDKRYAPAIAVEIEHWAKEQLGV
What is the function of this protein?
PKS-NRPS hybrid synthetase that, alone, is sufficient to produce naringenin chalcone, the direct precursor of naringenin, by using p-coumaric acid (p-CA) or p-hydroxybenzoic acid (p-HBA) with the involvement of malonyl-CoA molecules (PubMed:36289208).  The adenylation (A) domain activates p-CA or p-HBA as adenylates, which are transferred to the thiol group of the pantetheinyl residue of the T domain, and further transferred to the adjacent PKS portion of fnsA (PubMed:36289208).  Besides p-CA and p-HBA, the A domain is also able to activate other substrates such as cinnamic acid and salicyclic acid (PubMed:36289208).  Within the PKS portion of fnsA, p-CA and p-HBA act as starter units for respectively three or four malonyl-CoA molecules for elongation by the AT and KS domains of fnsA (PubMed:36289208).  Afterwards, naringenin chalcone is cyclized through Claisen condensation and thereby released either spontaneously or catalyzed by the TE domain (PubMed:36289208).  Finally, naringenin chalcone is converted to naringenin spontaneously or by a chalcone isomerase (PubMed:36289208).
What are the official names of this protein?
Naringenin synthase, PKS-NRPS hybrid synthetase fnsA, PKS-NRPS fnsA.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the NRP synthetase family.