PharMolix/UniProtQA huggingface dataset:
Protein: MTNA_PICST
Sequence: MASTAKTLQAIKFDKENISLQILDQLLLPYTTHYLDIKTIEDAFSAIRLMQVRGAPAIAIVGAFAVVVDTNASLKNGGNKTVSKLFDSIDYLETSRPTAVNLANALNDIKKLVSAKFGQNDLVDEDVYQIIYKYSVALYEDDLANNFKIGANGLNYIVETLKKDGFKGAFSIVTICNTGSLATSGHGTALGIIRSTYDKLKKSESSEEFWLDHVYPCETRPYNQGAKLTTYELHYEQIPFTLICDNMVSSLVNTLSSNKNIQDNAAAPVKFIIVGADRVVKNGDTANKIGTFQLSTIANFFNSNKLSGSANKIKFIVAAPRTTIDLNTATGDEIVIEERPANELTTLKGPVLREDGSIGDKYTVGIATPGISVWNPAFDVTPHALIDAIVTEEEKVYTKNSHGEFELSK
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TEPS3_ANOGA
Sequence: MWQFIRSRILTVIIFIGAAHGLLVVGPKFIRANQEYTLVISNFNSQLSKVDLLLKLEGETDNGLSVLNVTKMVDVRRNMNRMINFNMPEDLTAGNYKITIDGQRGFSFHKEAELVYLSKSISGLIQVDKPVFKPGDTVNFRVIVLDTELKPPARVKSVHVTIRDPQRNVIRKWSTAKLYAGVFESDLQIAPTPMLGVWNISVEVEGEELVSKTFEVKEYVLSTFDVQVMPSVIPLEEHQAVNLTIEANYHFGKPVQGVAKVELYLDDDKLNQKKELTVYGKGQVELRFDNFAMDADQQDVRVKVSFIEQYTNRTVVKQSQITVYRYAYRVELIKESPQFRPGLPFKCALQFTHHDGTPAKGITGKVEVSDVGFETTKTSDNDGLIKLELQPSEGSEQLGINFNAVDGFFFYEDVNKVETVTDAYIKLELKSPIKRNKLMRFMVTCTERMTFFVYYVMSKGNIIDAGFMRPNKQTKYLLQLNATEKMIPKAKILIATVAGRTVVYDYADLDFQELRNNFDLSIDEQEIKPGRQIELSMSGRPGAYVGLAAYDKALLLFNKNHDLFWEDIGQVFDGFHAINENEFDIFHSLGLFARTLDDILFDSANEKTGRNALQSGKPIGKLVSYRTNFQESWLWKNVSIGRSGSRKLIEVVPDTTTSWYLTGFSIDPVYGLGIIKKPIQFTTVQPFYIVENLPYSIKRGEAVVLQFTLFNNLGAEYIADVTLYNVANQTEFVGRPDTDLSYTKSVSVPPKVGVPISFLIKARKLGEMAVRVKASIMLGHETDALEKVIRVMPESLAQPKMDTSFFCFDDYKNQTFPFNLDINKKADNGSKKIEFRLNPNLLTMVIKNLDNLLAVPTGCGEQNMVKFVPNILVLDYLYATGSKEQHLIDKATNLLRQGYQNQMRYRQTDGSFGVWEKSGSSVFLTAFVATSMQTASKYMNDIDAAMVEKALDWLASKQHSSGRFDETGKVWHKDMQGGLRNGVALTSYVLTALLENDIAKVKHAVVIQNGMNYLSNQLAFINNAYDLSIATYAMMLNGHTMKKEALDKLIDMSISDNNKKERYWGTTNQIETTAYALLSFVMAEKYLDGIPIMNWLVNQRYVTGSFPRTQDTFVGLKALTKLAEKISPSRNDYTVQLKYKKSTKYFNINSEQIDFQNFLEIPEDTKKLEINVGGIGFGLLEVIYQFDLNLVNFEHRFKLDLEKQNTGSDYELRLRVCANYIPELTDSQSNMALIEVTLPSGYVVDRNPISEQTTVNPIQNMEIRYGGTSVVLYYYNMGTERNCFTVTAYRRFKVALKRPAYVVVYDYYNTNLNAIKVYEVDKQNVCEICEEEDCPAEC
What is the function of this protein?
Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.
What are the official names of this protein?
Thioester-containing protein 1 allele S3, TEP1s, TEP1-F.
What are the subcellular locations of this protein?
Secreted. Note=Secreted as a full-length protein into the hemolymph.
Protein: ADH7_MOUSE
Sequence: MGTAGKVIKCKAAVLWGVNQPFSIEEIEVAPPKAKEVRVKILATGICRTDDHIIKGSMVSKFPVIVGHEAVGVVESVGEGVTTVRPGDKVIPLFLPQCRECNACLNPEGNLCIRSDLTGRGVLADGTTRFTCKGKPVQHFMNTSTFTEYTVLDESSVAKVDGAAPPEKACLIGCGFSTGYGAAVKTAKVTPGSTCVVFGLGGVGLSVIMGCKAAGASRIIGIDINKDKFQKALAVGATECISPKDSTKPISEVLSDMTGNTIQYTFEVIGRLETMVDALSSCHMNYGTSVVVGAPPSAKMLTYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTEFLEKKFDLDQLITHTLPFNNINEGFELLYSGKSIRTVLTF
What is the function of this protein?
Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives.  Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid.  In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives.  Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal.  Catalyzes in the oxidative direction with higher efficiency.  Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.
What are the official names of this protein?
All-trans-retinol dehydrogenase [NAD(+)] ADH7, ADH-C2, Alcohol dehydrogenase 7, Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Omega-hydroxydecanoate dehydrogenase ADH7, Retinol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_XYLFA
Sequence: MKFSENWLRNHVPIQANRDVLVATLTAIGLEVENVAVLGEALDLIVVARIVNVVPHPESDRLQICQVDAAQDTLLQIVCGASNVRPGLVVPLALLGAKIGALTIKSTTLRGVESNGMLCSAKELGLDTEASGLMELPDDAPIGTPLADYLALPDASIEIKLTPNRADCFSVRGIAFDVAAACASEVTPLHIDEIPAVSARTLPVELHAGANAPRYCGCVIEGIDPAAPTPVWMAERLRRSGIRPVSLLVDITQYVMLELGQPMHAFDVDTLRGPIGVRLSRNDEALKLLDGRTVVLDNDFLVVTDADQPIALAGLIGGWETRITDTTVNVFLEAAHFAPVAIMGRGRKLGLHTDASHRFERGVDPALPPQAIAFATRLILELAGGKPGSLIRVELPEYLPAPASILLRRTRIARLLGIVIDDVEVERILHALGMQVTTQAEGWRVVAPSRRFDIAIEEDLIEELVRIRGYEHLPTALPIGASHIAMPSETRLDMTSVRRQLIARELQETINYAFIDAELLRRWQLNTGQVMLMNPLSAELAVIRPRLLPGLVAALGRNIARQLERVRLFELGNVFTASDEAGAAPLETQHVAAAVCGDAFALQWGEQARKVDFYDLKGDLESLAAASGAVLTFHSSAQPWGHPGRSADVWCDDTCIGWIGQLHPALTQTLEINVDVIAFELALEPLVRGALPRAHALSRFPFVRRDLACVVPEHVTWSELAITVRDVIGSLLRDVKLFDRYVGKGIEPGFKSLAIGLILQDDTRTLIDRDVDDIMAKVVMAIQQRHDVRIRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_CAUVC
Sequence: MAINIIAQLEQEESARLLAARAIPDFRPGDTLRVNVKIKEGERERVQAYEGVCIARAGTGVHESFTVRKISFGEGVERLFPLLSPSIESIEVKRRGVVRRAKLYYLRDRRGKSARIAERAGGPKASASTEA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PYRB_METBU
Sequence: MSFKDLHIISMKSFSRDMIDHVLNTAEMLEPIAKGKTKSDLLKGKILGVLFFEPSTRTRMSFETAMMRLGGDVLSLGSVDASSIAKGETLADTIRVVNGYANAIVLRHNKEGAAQLASEFSSVPILNAGDGAGHHPTQTFLDLYTIRRESHLDGLKIALAGDLKYGRTVHSLCYALSLYGAEITLVSPKELRLPADIIEDLRSRNIKLTEIEYIEDAIENVDVLYVTRIQKERFPDPAEYRKVANSLLISPELLEKAKPELKVMHPLPRTNEIDPRVDNTKHACYFKQSFYGVPIRMALLALVMGALE
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RPOB_ACIBT
Sequence: MAYSYTEKKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKSPKNREDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVRECILRGSTYAAPMRVKIRLIIKDRETKSIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKTHSSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKVPVYLDMGSYQIDLVPERLRGEMAQFDITDNEGKVIVEQGKRINARHVRQMEAAGLTKLSVPDEYLYERITAEDITLRDGEVIAANTLLSHEVMVKLAEGGVKQFNILFTNDIDRGSFVADTLRADLTRDREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFNRRLGRPYEVGTDQKSREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVIDGRVTDDVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCVIANRGGVIEYVDASRIVIRVNEDEMVAGEAGVDIYNLIKYTRSNQNTCINQNVIVNLGDKVARGDILADGPSTDMGELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGLEKDDRALAIEKAQLDSYRKDLKEEYKIFEEAARERVIRLLKGQESNGGGSTKRGDKLSEDLLSGLELVDLLEIQPADEAIAERLTQIQVFLKEKSAEIDEKFAEKKRKLATGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILETHLGMAAKGLGDKIEKMLKEQRTVLELREFLDKIYNKVGGEQEDLDSLTDEEILALAGNLRAGVPLATPVFDGAEESQIKDLLELADISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINID
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: SYT_VIBVU
Sequence: MPIITLPDGSQRQFDNPVSTMDVALSIGPGLAKATIAGRVNGQRVDACDLIEEDASLEIITTKDEVDGLEIVRHSCAHLLGHALKQLYPNAKMAIGPTIDNGFYYDIDLEESLTQEDLEKIEARMKALAKTKYQVIKKKVSWQEARDAFEARGETYKMEILDENVSRDDRPGLYHHEEYIDMCRGPHVPNMSFCQHFTLLNVAGAYWRGNSDNKMLQRIYGTAFHDKKALKDHLTRLEEAAKRDHRKIGKQLDLFHMQQEAPGMVFWHHNGWSVFRDLEVFIREKLTEYGYQEVKGPLMMDRVLWERSGHWDKYADAMFTTSSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGIMRVRGFTQDDAHIFCTESQIQDEVTNCIKMVYDTYQTFGFDNIAVKLSTRPEQRVGSDEIWDQSEEALKQALESMDIAYEIQEGEGAFYGPKIEFTLFDCLGRAWQCGTVQLDFNLPNRLGATYVGENNERLVPVMIHRAILGSLERFIGILIEEYAGFFPTWLAPEQAVIMNITDKQADYVQEIAQKLQKCGIRAKADLRNEKIGFKIREHTLKRVPFMLVCGDQEMEAGEIAVRTRKGNDLGKFKVDDFVSYIQDQIASRKLNLEE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_HAEIN
Sequence: MARRPLVMGNWKLNGSKAFTKELIEGLKAELHDVTGCDVAIAPPVMYLGTAEAALSGCGCSCGGKSVIQLGAQNVDINVKGAFTGDISTEMLKDFGAKYIIIGHSERRTYHKESDEFVAKKFGALKEAGLVPVLCIGESEAENEAGKTEEVCARQIDAVINALGVEAFNGAVIAYEPIWAIGTGKSATPAQAQAVHAFIRGHIAAKSQAVAEQVIIQYGGSVNDANAAELFTQPDIDGALVGGASLKAPAFAVIVKAAAAAKN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCR_ECOLI
Sequence: MTTRQHSSFAIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSTQMTLSTYILGFALGQLIYGPMADSFGRKPVVLGGTLVFAAAAVACALANTIDQLIVMRFFHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLMAPIVGGWVLVWLSWHYIFWILALAAILASAMIFFLIKETLPPERRQPFHIRTTIGNFAALFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIEINHVAPENFGYYFALNIVFLFVMTIFNSRFVRRIGALNMFRSGLWIQFIMAAWMVISALLGLGFWSLVVGVAAFVGCVSMVSSNAMAVILDEFPHMAGTASSLAGTFRFGIGAIVGALLSLATFNSAWPMIWSIAFCATSSILFCLYASRPKKR
What is the function of this protein?
Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance (PubMed:2694948).  Probable membrane translocase.  A transporter able to export peptides.  When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed:20067529).  Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide (PubMed:20067529).
What are the official names of this protein?
Bicyclomycin resistance protein, Sulfonamide resistance protein.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Bcr/CmlA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y8383_DICDI
Sequence: MAKVSNYNNNNNNNNNNNNNNNNNNNYNQNSNNNINSNNNDKFNNRLKCLNCCRLGHTKANWWINNNNNNKDNSYNNNKINNIRDEEDVDLNGDDTFNDSNNDNSPSRGSINAIGENQEKLEKQNQMVISEKDCQENTSSKSIFSSNISIYRKGVKFIWNDKLCEYEINDKT
What are the official names of this protein?
Putative uncharacterized protein DDB_G0271526.
Protein: MVD2_ARATH
Sequence: MATEKWVFMVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNGKEISLSGSRYQNCLREIRGRAGDVEDMEKGIKIRKKDWEKLNLHIASHNNFPTAAGLASSAAGFACLVFSLAKLMNVDEDPSHLSAIARQGSGSACRSLFGGFVKWTMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSLLLQHRAKEVVPKRILQMEEAIKNRDFASFTQLTCTDSNQFHAVCLDTSPPIFYMNDTSHRIISLVEKWNRSEGTPQVAYTFDAGPNAVLIARNRKVAVQLLQGLLYYFPPKSDTDMKSYVVGDNSILKEAGLDGASGVENLQPPPEIKDNIGSQDQKGEVSYFICTRPGKGPIVLHDQTQALLDPETGLPK
What is the function of this protein?
Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids.  Is specific for (R)-5-diphosphomevalonate (MVAPP).  The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP.
What are the official names of this protein?
Diphosphomevalonate decarboxylase MVD2, peroxisomal, Mevalonate 5-diphosphate decarboxylase 2, AtMDD2, AtMVD2.
What is the protein family that this protein belongs to?
Belongs to the diphosphomevalonate decarboxylase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: LIPA_VIBA3
Sequence: MSKPIQMEKGVKYRDADKMALIPVKNMPAEQKEVLRKPAWMKIKLPSDSHRIQEIKSAMRKNNLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPNAPEAEEPKKLAKTIKDMKLKYVVITSVDRDDLRDGGAQHFADCNREIREQNPNIRIETLVPDFRGRMDVALELMKDNPPDVFNHNLETAPRLYRKARPGANYKWSLDLLRKFKEQHPNIPTKSGVMMGLGETKEEIVQVLKDLREHGVTMLTLGQYLAPSRHHLPVERYVPPSEFDELKEIALELGFTHAACGPFVRSSYHADLQAQGMEIK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNU23_CAEEL
Sequence: MSFYGQSGSQASGTNHRRTWDEKEYSLAAQQRLLDEKEAEDIRLGKKKKDEPKVKREMLQAREYKVDLDSKVGKSVVITKATPSAETGGFYCDVCDCVVKDSINFLDHINGKNHQRNIGMSMKTKKSTVADVRERFKLMKDKKEREKKEAQVEQLLEDVQEEEARMADFKKDKKTDNRKRKRDTRKDEEEDDDEDDSGLDPEIRAMMGFSGFSTSKR
What are the official names of this protein?
Putative zinc finger matrin-type protein snu-23.
What are the subcellular locations of this protein?
Nucleus.
Protein: MAEL1_DROPS
Sequence: MAQNKPNAFMAFVADWRACNRFGRGLSTSEAVAKCGPIWEGMSDRERGPYKSKAKDSNVLERESKTERLNCPGVAFSKMQVEKNEAIDAELQMKRNIKRIVLKATNSMKLEEEEFLFVSFNYFTKALNGDVYQPAELSACRFSLKGGISSNYSTMINPGHIIFGQTSDAQDHSRTTHKLPLPPNAMGEKNLGNLYSDTLKWLSASNDEEDEQYDHPVIVYTTPELMPVVKSCFRYLACEGDTDKHAKKIIVYDICYLFLTLKKTVLDLVGVPSDHMNIHVTNSFFRRDFFEFSSGIACDYHEEVDRTKYCTKSMVLRWGYMISHYICGDLAIPLQPRKHVPIEVKHSYTVTPGDSSLALDGTSTDSGYSGY
What is the function of this protein?
Involved both in the piRNA and miRNA metabolic processes.  As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons.  As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam).  Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
What are the official names of this protein?
Protein maelstrom 1.
What is the protein family that this protein belongs to?
Belongs to the maelstrom family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein: TIR1_YEAST
Sequence: MAYTKIALFAAIAALASAQTQDQINELNVILNDVKSHLQEYISLASDSSSGFSLSSMPAGVLDIGMALASATDDSYTTLYSEVDFAGVSKMLTMVPWYSSRLEPALKSLNGDASSSAAPSSSAAPTSSAAPSSSAAPTSSAASSSSEAKSSSAAPSSSEAKSSSAAPSSSEAKSSSAAPSSSEAKSSSAAPSSTEAKITSAAPSSTGAKTSAISQITDGQIQATKAVSEQTENGAAKAFVGMGAGVVAAAAMLL
What is the function of this protein?
Component of the cell wall.  Required for anaerobic growth.
What are the official names of this protein?
Cold shock-induced protein TIR1, Serine-rich protein 1, TIP1-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the SRP1/TIP1 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI- anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI- CWP).
Protein: RS8_SALRD
Sequence: MSGISDPVSNYMAQLRNAQEAEQTYVDIPASKLKRAMTQILLEKGYIKNFVNIDDEKQGLLRVYLKYDEYDQPAIRMLERVSRPGRREYADSDNLPEVKNGLGIVILSTSRGVMSDKEARRFGVGGEVLAKVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: FEN1_DEBHA
Sequence: MGVKGLNQLIKEHAPEAFKEFQLKNLFGRKIAIDASMCLYQFLIAVRQAEGQQLTNDEGETTSHLSGMFYRTIRLVENSIKPVYVFDGKPPVLKGGELEKRLLRREEAIKQRENIKDEGTIEDMVRYEKRTVRVTREQNDEAKKLLELMGVPYVNAPCEAEAQCAELARGGKVFAAASEDMDTICYQPPFLLRHLTFSEARKMPIDQIQYEKVLEALEMDRETFIDLCILLGCDYCETIRGVGPVTAFKLIKEHGSLDKIVEYLTNNPDKTNFKVPEDWPYDEARKLFINPDTIDASEVNLKWKEPDVEGLIQYMVKEKGFSEDRIRSGAEKLKKGLKGGVQGRLDGFFQSVPKPKDSADKKRKNDTKSAKSKKAKTRK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: CHEW_THEMA
Sequence: MKTLADALKEFEVLSFEIDEQALAFDVDNIEMVIEKSDITPVPKSRHFVEGVINLRGRIIPVVNLAKILGISFDEQKMKSIIVARTKDVEVGFLVDRVLGVLRITENQLDLTNVSDKFGKKSKGLVKTDGRLIIYLDIDKIIEEITVKEGV
What is the function of this protein?
Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.
What are the official names of this protein?
Chemotaxis protein CheW.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR11_IPOPU
Sequence: MAKAIPRRSSRRNGRIGSRKSARRIPKGVIHVQASFNNTIVTVTDVRGRVVSWSSAGTSGFKGTRRGTPFAAETAASNAIRTVVDRGMLRAEVMIKGPGLGRDAALRAILQSGILLTFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RM55_HUMAN
Sequence: MAAVGSLLGRLRQSTVKATGPALRRLHTSSWRADSSRASLTRVHRQAYARLYPVLLVKQDGSTIHIRYREPRRMLAMPIDLDTLSPEERRARLRKREAQLQSRKEYEQELSDDLHVERYRQFWTRTKK
What are the official names of this protein?
39S ribosomal protein L55, mitochondrial, L55mt, MRP-L55, Mitochondrial large ribosomal subunit protein bL31m, Mitochondrial large ribosomal subunit protein mL55.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL55 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RSMG_THEP3
Sequence: MKNKSVEMLIEGAKEWGIFLEMFHVEHFQKYYALLLEWNQKMNLTAITEESEVVIKHFLDSLSVVKSGKIKEEEKIIDVGTGAGFPCIPLKIVFPKLKATLLDSSKKRITFLEEVINKLGINEIELIHGRAEDIGKDIKYREQFDLSMARAVAPLNILLEYTLPFVKVDGYFIALKGREIEEEIENSQRALKELKGEIEEVKEIKLPYSDIVHHLVIIKKIDNCPTKYPRRANAIQRSPL
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_BURTA
Sequence: MANSAQARKRARQAAKANSHNSALRSKFRTAIKAVRKAIDAGDQAKAAELFKAATKTIDTIADKKIVHKNKAARHKSRLSAAVKGLQAQAAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: COX12_YEAST
Sequence: MADQENSPLHTVGFDARFPQQNQTKHCWQSYVDYHKCVNMKGEDFAPCKVFWKTYNALCPLDWIEKWDDQREKGIFAGDINSD
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 12, mitochondrial, Cytochrome c oxidase polypeptide VIb.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6B family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
Protein: ACPS_HELPJ
Sequence: MIGIDIVSIARIEKCVKRFEMRFLERFLSPSEIVLCKDKSSSIAGFFALKEACSKALQVGIGKELSFLDMRISKSPKNAPLITLSKEKMDYFNIQSLSASISHDAGFAIAVVMVSSSNL
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.