PharMolix/UniProtQA huggingface dataset:
Protein: SYC_BACLD
Sequence: MTLTLYNTLTRKKEPFVPLEEGKVKMYVCGPTVYNYIHIGNARPAIVFDTVRKYLEYKGYEVQYVSNFTDVDDKLIKAANELGEEVPVIAERFIKAYFEDVGSLGCTKADCHPRVTENMDEIIDFIQTLIDKGYAYEADGDVYYKTRSFEGYGKLSHQSVDELRSGARIQVGEKKEDALDFTLWKAAKDNEISWDSPWGKGRPGWHIECSAMARKYLGDSIDIHAGGQDLAFPHHENEIAQSEALTGKPFAKYWLHNGYINIDNEKMSKSLGNFVLVHDIIKEHDPQVLRFFMLSVHYRHPINYSVELLENTKNAFGRLKTAYSNLQHRLKSSTNLTEGDSEWLEKIEEQRKAFQTAMDDDFNTANAISVLFDLAKHANYYLQEKNTAEHVIQAFIQLFDEICSVLGFSLKEQELLDKDIEELIEKRNEARRNRDFATSDQIRDQLKSMNIILEDTPQGTRWKRGES
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSD_FELCA
Sequence: MNGTEGPNFYVPFSNKTGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMMNKQFRNCMLTTLCCGKNPLGDDEASTTGSKTETSQVAPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  Required for photoreceptor cell viability after birth (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: PYRB_DESRM
Sequence: MFWQRKDLLGLRYLTPEEINLILDTAVPMKEIIGRKIKKTPTLRGRSMVTLFYENSTRTRSSFDLAGKFLSADTVGLTASSSSVAKGESLRDTGLTLTAMGVDVVVMRHPASGAAEYLAKCIPAAVINAGDGTHEHPTQALLDMFTIREKKGSMAGLKVVIVGDILHSRVARSNIWGLTKMGAEVRVVGPITLMPKDIEKMGVKVYHRLEDALEGADVVNVLRIQLERQQQGLFPSLREYSRLYGINQKRLELTASDAIILHPGPMNRGVEIEHQVAYGNRSFINEQVTNGVAVRMALLYLLTGGEYHALSN
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: PYC1_ARTPT
Sequence: MRVFKVTACVPSQTRIRTQRELQNTYFTKLVPYDNWFREQQRIMKMGGKIVKVELATGKPGTNTGLL
What is the function of this protein?
Rod linker protein, associated with allophycocyanin.  Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer (By similarity).
What are the official names of this protein?
Phycobilisome 7.8 kDa linker polypeptide, allophycocyanin-associated, core, LC 7.8.
What is the protein family that this protein belongs to?
Belongs to the phycobilisome linker protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=This protein occurs in the rod, it is associated with allophycocyanin.
Protein: RS11_COREF
Sequence: MPPKARSGARRTGRRVVKKNVAQGHAYIKSTFNNTIVSITDPNGAVISWASSGHVGFKGSRKSTPFAAQMAAENAARKAMDHGMKKVDVFVKGPGSGRETAIRSLQAAGLEVSSISDVTPQPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: MUTA_CAEEL
Sequence: MYLQLLKPTLLRCSTRPSSSGAYTRSPIDQKWAAMAKKAMKGREADTLTWNTPEGIPIKPLYLRSDRDCDAQRSVELPGQFPFTRGPYPTMYTQRPWTIRQYAGFSTVEESNKFYKENIKAGQQGLSVAFDLATHRGYDSDNPRVFGDVGMAGVAVDSVEDMRQLFDGINLEKMSVSMTMNGAVVPVLAMYVVAAEEAGVSRKLLAGTIQNDILKEFMVRNTYIYPPEPSMRIIGDIFAYTSREMPKFNSISISGYHMQEAGADAVLEMAFTIADGIQYCETGLNAGLTIDAFAPRLSFFWGISMNFYMEIAKMRAARRLWANLIKERFSPKSDKSMMLRTHSQTSGWSLTEQDPYNNIIRTTIEAMASVFGGTQSLHTNSFDEALGLPTKFSARIARNTQIIIQEESGICNVADPWGGSYMMESLTDEIYEKALAVIKEIDELGGMAKAVASGMTKLKIEEAAAKKQARIDAGKDVIVGVNKYRLDHEQQVEVLKIDNAKVREEQCAKLNHIRATRDAEKAQKALDAITEGARGNGNLMELAIEAARARCTVGEISDAMEKVFNRHAAVNRLVSGAYKSEFGETSEMSQVLERVKSFADRDGRQPRIMVAKMGQDGHDRGAKVIATGFADLGFDVDVGPLFQTPLEAAQQAVDADVHVIGASSLAAGHLTLIPQLIGELKKLGRPDILVVAGGVIPPQDYKELYDAGVALVFGPGTRLPACANQILEKLEANLPEAPGKAASR
What is the function of this protein?
Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle.  MCM has different functions in other species (By similarity).
What are the official names of this protein?
Probable methylmalonyl-CoA mutase, mitochondrial, MethylmalonylCoA mutase homolog 1, MCM.
What is the protein family that this protein belongs to?
Belongs to the methylmalonyl-CoA mutase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: TRPA_METEP
Sequence: MTARIDAAFARCRAEGRAALVTYVMAGDPDPETSLKVLEALPKAGADIVEFGLPFTDPMADGPAIQAAGLRALKAGQDLRGTLALVRRFREGDDRTPVVLMGYYNPIHTYGVPHFLEDAQAAGIDGLIVVDLPPEEDEELCLPALEKGLAFIRLATPTTDEARLPAVLANTAGFVYYVSITGVTGTATPDFGRVSQAVSRITAHTNLPVVVGFGVKTGAHAAEIARGADGVVVGSALVDALARSLEPGDRAGSGTVEAVTSLVRELAQGVRSTAKAPAGA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: EXOS2_BOVIN
Sequence: MALEMRLPVARKPLSESLGRESKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYNGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWVYPTPEHKEDDAGGFIANLEPVSLTDREVISRLRNCIVSLATQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  It seems to be involved in degradation of histone mRNA.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 (By similarity).
What are the official names of this protein?
Exosome complex component RRP4, Exosome component 2, Ribosomal RNA-processing protein 4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Nucleus.
Protein: HUTH_GLUOX
Sequence: MTTSIFTLTPGKITLSDLRDFYFGQMDVRLDDGTFEALQRAAESVERIVGRGEPVYGVNTGFGKLAKTRIPDDRLRDLQRNLVLSHAAGIGQPMPERVVRLILLLKANGLARGYSGVRPQIVQLLLDMLNQGVVPVIPEKGSVGASGDLAPLAHMSAVVIGEGEAFYQGKRLKGDEALKAAGLEPLVLGAKEGLALLNGTQASTALAIAALLDAERLFHAALITGGLTLDAARGTDAPFDPRLHELRGQKGQIECAAVYRALMQGSAIRASHLEDDERVQDPYCLRCQPQVMGACLDNLRQAARVLVIEANAVSDNPIHFPDTDEMISGGNFHAEPVAIAADLMAIAVSEVGAIAERRLALLVDAQMSGLPPFLVQDSGLNSGFMIAQVTAAALASENKTLAHPASVDSLPTSANQEDHVSMATFAARRVGDIVDNVRTIIAVEYLAAVQGLDFLAPLETSAPLLEVAKTLRKTVPFFAQDRLFTPDMEAARALIIDGALGSCVGSGVALPALEG
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCM1_KOMPG
Sequence: MRLSRIGTPKVSVTRVIPVRNVVIARRKPVRASNTDAKTWLMKEEQRRIRQKEQEMKQRLEELERFKTKVQKSYIRKEDRHLAQEIEKDLDIITDDYNLDSDVDLVFGELMQAEEQPKSLKSLPGASDASDNTDKSVELFSFPSPNLTLPEKVIHHIGPLVKHISNPENIQWGRLLLDLEKNQGFNGLSAVDVTRLIQNIPKEEKYQHMSLIHEMMFNSGISPDRYLTDLMMTAFSERSYYEPLVEALFQDYDINGWAPTDYTFGALIKVYSKGKKLDKINNLLNQMKLKYHKEPNKKIYTMVLQTCMKIDDYKKTSEVFDAMKFNSVATNPDTTAYGSMILMHVLNDNVEAALDLYDNLETEPDETILLALARGCSSRKVLINRGWDFIIEYYKRKFPLNEKLMTVMMYLTSRDGDLSLTRAIYNTIHESRFKMTESFSMNKNDGIALNVLLRGYFKYPDNHTVQSKTNDAVVALRRSTLALNHFGYHPKATPFLPVNELEEKHILPEVQAIWSYIILHYPDIVTSELVGTYLMILATRGSMADFNKAFEELTLKPVFEQVDNAVAVEEESEQSSELSDLRLTPLAIRLSSNIQIKYPRNHDIYHIALQACINNKDIELGQRIWQERGRFRKTPEFSMQPRNVKHNQDFEFARDMLKLLVNCNELNDACRLLLSTETQFNWEWTYVKPVYIMAEQLGDEYAKKVVRRVVRNKKSKWREEYLQGM
What is the function of this protein?
RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts.  Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity).
What are the official names of this protein?
Mitochondrial group I intron splicing factor CCM1.
What is the protein family that this protein belongs to?
Belongs to the CCM1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y1481_STAA9
Sequence: MKNYSFYQFVMTVRGRHDDKGRLAEEIFDDLAFPKHDDDFNILSDYIETHGDFTLPMSVFDDLYEEYTEWLKF
What are the official names of this protein?
UPF0346 protein SaurJH9_1481.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: Y217_DEHMC
Sequence: MPRPYKCRRISEIPKVAYYKPAGIPLSMLEENQLSTEEAEALRLKDLLGLEQAQAALQMNISRPTFQRMLYSARYKVADALLNGKALRIEGGVFEIDARPCCQRQTPPCQPDPPEQT
What are the official names of this protein?
UPF0251 protein cbdbA217.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: TRPD_GEOMG
Sequence: MIKKAIAKVVERIDLTEAEMIEVMDQIMSGEATPAQIASFITALRMKGETVEEITGAARVMRDRATPIRVGKGVLDIDRDDINIDQETILDVVGTGGDGTNTFNISTTVSFVVASCGVKVAKHGNRAVSSACGSADVLESLGVSLDVTPETVENAIARIGIGFLFAPALHGAMKHAIGPRKEIGIRTIFNILGPLTNPAGADCQVLGVYREDLVEPLAHVLHKLGCKRGFVVFGMDGMDEITLTRETRVAEVTREGVTVRTITPEEFGFASCPPGDLRGGDAAGNARIVRSILDGATGPRRDVVLLNAAYALVAAGKATDPAEGIRLAAEAIDSGRALAKLEELIALTNE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: AROP_ECOL6
Sequence: MEGQQHGEQLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAFLIMRQLGEMVVEEPVAGSFSHFAYKYWGSFAGFASGWNYWVLYVLVAMAELTAVGKYIQFWYPEIPTWVSAAVFFVVINAINLTNVKVFGEMEFWFAIIKVIAVVAMIIFGAWLLFSGNGGPQASVSNLWDQGGFLPHGFTGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQVIYRILIFYIGSLAVLLSLMPWTRVTADTSPFVLIFHELGDTFVANALNIVVLTAALSVYNSCVYCNSRMLFGLAQQGNAPKALASVDKRGVPVNTILVSALVTALCVLINYLAPESAFGLLMALVVSALVINWAMISLAHMKFRRAKQEQGVVTRFPALLYPLGNWICLLFMAAVLVIMLMTPGMAISVYLIPVWLIVLGIGYLFKEKTAKAVKAH
What is the function of this protein?
Permease that is involved in the active transport across the cytoplasmic membrane of all three aromatic amino acids, phenylalanine, tyrosine and tryptophan.
What are the official names of this protein?
Aromatic amino acid transport protein AroP, Aromatic amino acid:H(+) symporter AroP, General aromatic amino acid permease.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YDEF_BACSU
Sequence: MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPGTKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTKPTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQRGGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPIKSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVIEDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALYNLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIFRWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQGLMILRRLLDDLT
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YdeF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: MURC_LACLM
Sequence: MEKTYHFTGIKGSGMSALALMLHQMGKNVQGSDSTDYFFTQRGLEQAGVPLLPFDEKNIKPEFELIVGNAFRDDNNVEIAFAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGMLAHVMSNIVDTSYLIGDGTGRGNAGSEYFVFESDEYERHFMPYHPEYTIMTNIDFDHPDYFEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLSAKAPIYYYGFEANDDYRAENLIRSTRGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTDVADHLLTFRGVKRRFTEKKVGETVIIDDFAHHPTEIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEVLDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVIELDNVSPLLDHDRGVYVFMGAGNIQKYEIAFEKLLSQTSTNLQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_CLOPE
Sequence: MDKIRKQEIIAKHARHEGDTGSPEVQIALLTERINSLTDHLRTHKKDHHSRRGLLMMVGQRRGLLNYLYEQDIERYRAIIKELGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RIMP_BRUSU
Sequence: MTEQVQANETETPVAVADERIIRETGIDAKVAGIVEPVINTLGFRLVRVRLSGLNGQTLQIMAERPDGTMTVDDCELVSRTVAPVLDVEDPISGKYHLEISSPGIDRPLVRKSDFSDWAGHIAKVETSIVHEGRKKFRGRIVVGEADSVTIESDQISYGNEPVVRIPFDLISDARLVLTDDLIRDALRKDKALREGRIPGDDLGAEPEDAASTETQEKK
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NS1_I76AM
Sequence: NTVSSFQVDCFLWHVLKRFADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILEEESDEALKMNIASVPASRYLTDMTLEEMSRDWFMLMPKQKVAGSLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTDEDVKNAIGILIGGLEWNDNTVRVSETLQRFAWRSSNEDGRPPLPPKQKWKMARTIEPEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: NEDD8_HUMAN
Sequence: MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLRQ
What is the function of this protein?
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:9694792, PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:15242646, PubMed:14690597).  Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (PubMed:9694792, PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:20688984).  Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity (PubMed:15242646).  Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (PubMed:14690597).
What are the official names of this protein?
NEDD8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8, NEDD-8, Ubiquitin-like protein Nedd8.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Nucleus. Note=Mainly nuclear.
Protein: MINE_YERPN
Sequence: MALLDFFLSRKKPTANIAKERLQIIVAERRRGDSEPHYLPDLKRDILAVICKYIQIDPEMLHVQFEQKGDDISVLELNVTLPETEETPK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: DNAK_CHLMU
Sequence: MSEKRKSNKIIGIDLGTTNSCVSVMEGGQPKVIASSEGTRTTPSIVAFKGSETLVGIPAKRQAVTNPEKTLASTKRFIGRKFSEVESEIKTVPYKVAPNSKGDAVFEVENKLYTPEEIGAQILMKMKETAEAYLGETVTEAVITVPAYFNDSQRASTKDAGRIAGLDVKRIIPEPTAAALAYGIDKEGDKKIAVFDLGGGTFDISILEIGDGVFEVLSTNGDTHLGGDDFDEVIINWMLGEFKKQEGIDLSKDNMALQRLKDAAEKAKIELSGVSSTEINQPFITIDANGPKHLALTLTRAQFEHLASSLIERTKQPCAQALKDAKLSASDIDDVLLVGGMSRMPAVQAVVKEIFGKEPNKGVNPDEVVAIGAAIQGGVLGGEVKDVLLLDVIPLSLGIETLGGVMTPLVERNTTIPTQKKQIFSTAADNQPAVTIVVLQGERPMAKDNKEIGRFDLTDIPPAPRGHPQIEVTFDIDANGILHVSAKDAASGREQKIRIEASSGLKEEEIQQMIRDAELNKEEDKKRREASDIKNEADGMIFRAEKAIKDYQDKIPADLVKEIEEQIEKVRQAVKEDASTTAIKAASDELSARMQKIGEAMQAQSASAANAQGGPNINSEDLKKHSFSTRPPAGDNSSSTDNIEDADVEIVDKPE
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, 75 kDa membrane protein, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MSHR_CAPCA
Sequence: MPVLGSQRRLLGSLNCTPPATFPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAGALAARAAVVQQLDNVIDMLICGSMVSSLCFLGAIAVDRYISIFYALRYHSVVTLPRAWRIIAAIWVASILTSLLFITYYNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHARGIARLQKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHPTCGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEMA_INCAA
Sequence: MFFSLLLMLGLTEAEKIKICLQKQVNSSFSLHNGFGGNLYATEEKRMFELVKPKAGASVLNQSTWIGFGDSRTDKSNSAFPRSADVSAKTADKFRSLSGGSLMLSMFGPPGKVDYLYQGCGKHKVFYEGVNWSPHAAINCYRKNWTDIKLNFQKNIYELASQSHCMSLVNALDKTIPLQATAGVAKNCNNSFLKNPALYTQEVNPSVEKCGKENLAFFTLPTQFGTYECKLHLVASCYFIYDSKEVYNKRGCDNYFQVIYDSSGKVVGGLDNRVSPYTGNSGDTPTMQCDMLQLKPGRYSVRSSPRFLLMPERSYCFDMKEKGPVTAVQSIWGKGRESDHAVDQACLSTPGCMLIQKQKPYIGEADDHHGDQEMRELLSGLDYEARCISQSGWVNETSPFTEEYLLPPKFGRCPLAAKEESIPKIPDGLLIPTSGTDTTVTKPKSRIFGIDDLIIGLLFVAIVEAGIGGYLLGSRKVSGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEVSPGCWVIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQSDPFYWGSSLGLAITAAISLAALVISGIAICRTK
What is the function of this protein?
Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.  Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase.  This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.
What are the official names of this protein?
Hemagglutinin-esterase-fusion glycoprotein, HEF.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: MURA_MAGSA
Sequence: MDRIRIVGGTPLKGTITIGGAKNAALALMPACLLTEETLALSNLPHLVDITTMANLLAQHGVTMALNGDAANGGHTGRVLELTAAHIGNTTAPYDLVRKMRASVLVLGPLLARFGEARVSLPGGCAIGTRPVDLHLKALEQMGAKIELDGGYIIASVQGRLKGAHVIFPQITVGGTENILMAATLAEGETVIANAAREPEITDLAECLVAMGAKIEGIGTGTLKVQGVERLHGAEYSVVPDRIETGTYAVAAAITRGDIELVGARFDLMESVNKVLTECGVHVEETPRGMRVRADQGEITGVDIMTEPYPGFPTDMQAQLMALMSTAKGASMITETIFENRFMHVPEMTRMGARINVHGSSAIVRGAPKLSGAQVMATDLRASVSLVLAALAAEGETIVNRVYHLDRGYERVEEKLAACGAKIERLKDGVAE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_ACIBY
Sequence: MLKQTLLYTGKAKSVYETDNADHLILVFRDDASAFNGEKIEQLDRKGKVNNRFNAFIMEKLAEAGIETHFEKLLSPTEVLVKKLQMIPVECVIRNYAAGSLCRRLGVEEGKELTPPTFELFYKDDGLGDPMVNESQAIALGWATAEQLEQMKVLTYKVNDVLKALFAEGNMILVDFKLEFGVFHDRIVLGDEFSPDGCRLWDKDTKKKLDKDRFRQGLGGVVEAYEEVAARLGVDLSDI
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.