PharMolix/UniProtQA huggingface dataset:
Protein: DCUP_CERS5
Sequence: MTKTMLRALRGETLPTPPIWLMRQAGRYLPEYRATRAEAGDFLSLCYNPELAAEVTLQPIRRYGFDAAILFADILLLPQALGADLWFETGEGPRMSTITDMAGVEALKGKDEIHEKLAPVYETCRILARELPKETTFIGFAGMPWTVATYMIAGRGSKDQAAAHKLKDTDRPAFEALMDRITEATIEYLSKQVEAGCEVVKLFDSWAGSLKGQDFEDFAVAPAKKIIAELKARHPGLPIIAFPREAGEGYIGFAEKTGADCVAIDNSVSPEWAAENVQKGKSCVQGNLDPKYMITGGDELVQATKRVVEAFRNGPHIFNLGHGITPEADPENVTLLIETIRGK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_STRA5
Sequence: MITGIINLKKEAGMTSHDAVFKLRKILHTKKIGHGGTLDPDVVGVLPIAVGKATRVIEYMTESGKIYEGEITLGYATSTEDSSGEVISRTPLTQSDLSEDVVDHAMKSFTGPITQVPPMYSAVKVNGKKLYEYARSGEEVERPKRQITISEFRRTSPLYFEKGICRFSFYVSCSKGTYVRTLAVDLGIKLGYASHMSFLKRTSSAGLSITQSLTLEEINEKYKQEDFSFLLPIEYGVLDLPKVNLTEEDKVEISYGRRILLENEADTLAAFYENRVIAILEKRGNEFKPHKVLL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RL20_POLSJ
Sequence: MPRVKRGVTARARHKKVLALAKGFRGRRGNVFRIAKEAVMKAGQYAYRDRRTKKRVFRQLWIARINAASRSFGMTYSQFANGLKKAGIEIDRKVLSDMAIHDSAAFGAIVEQVKAKLAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NDB4B_ISOMC
Sequence: FLGSLFSIGSKLLPGVIKLFQRKKQ
What is the function of this protein?
Probably forms pores in target membranes.  Has antibacterial activity against Gram-negative bacterium E. coli NBRC 3972 (MIC=10 uM) and against Gram-positive bacteria S. aureus NBRC 13276 (MIC=2. 5-5 uM) and B. subtilis NBRC 3009 (MIC=0. 5-1 uM).  Toxic to cricket A. domestica.  Has hemolytic activity against sheep erythrocytes.
What are the official names of this protein?
Peptide Im-5.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Medium-length antimicrobial peptide (group 3) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Probably forms a helical membrane channel in the prey.
Protein: OADB_VIBCH
Sequence: MENILAMVRDFGLFHLQWGQGIMILVGLVLLYLAIVKRFEPLLLVPIGFGGILSNLPDAGLAMSAIENAVYAAKPEVMTAFSEVLQLSSYMPADIKQALSSATPLQMTTLHLLAEQYQYSDGMLYLFYSIAIASGAGPLIIFMGVGAMTDFGPLLANPKTLLLGAAAQFGIFTTVLGALALSSLGVMDFSVAQAAAIGIIGGADGPTAIYVSSMLAPELLGAIAVAAYSYMALVPMIQPPIMRALTTQEERKIQMQQLRQVHKLEKIGFPLLLLILIALLLPSATPLLGMFCFGNLMRECGVVERLSDTAQNALINIVTIFLGLSVGSKLMADKFLQPQTIGILVLGIVAFCVGTAAGVLMAKLMNRFSTTKLNPLIGSAGVSAVPMAARVSNKVGLEANAQNFLLMHAMGPNVAGVIGSAVAAGVMIKYVMG
What is the function of this protein?
Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
What are the official names of this protein?
Probable oxaloacetate decarboxylase beta chain.
What is the protein family that this protein belongs to?
Belongs to the GcdB/MmdB/OadB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURQ_ECODH
Sequence: MQFEKMITEGSNTASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVSGGGRLIYLGAGTSGRLGILDASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGGVNDLKNINLTAQDVVVGIAASGRTPYVIAGLEYARQLGCRTVGISCNPGSAVSTTAEFAITPIVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVNIVKNATGCSAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: CAPSD_PMMV0
Sequence: MAYTVSSANQLVYLGSVWADPLELQNLCTSALGNQFQTQQARTTVQQQFSDVWKTIPTATVRFPATGFKVFRYNAVLDSLVSALLGAFDTRNRIIEVENPQNPTTAETLDATKRVDDATVAIRASISNLMNELIRGTGMYNQALFEMASGFTWATIPYT
What is the function of this protein?
Capsid protein self-assembles to form rod-shaped virions about 18 nm in diameter with a central canal enclosing the viral genomic RNA.
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the virgaviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: RL1_BORPA
Sequence: MAKLSKRAAAIAQKIDRTKLYPVGEALNLVKETATAKFDESIDVAVQLGIDPKKSDQLVRGSVVLPAGTGKTVRVAVFAQGEKADAARAAGADIVGLDDLAEQIKAGQMDFDVVIASPDTMRVVGALGQVLGPRGLMPNPKVGTVTPDVATAVKNAKAGQIQYRTDKAGIIHATIGRASFGVEQLQNNLAALVDALQKARPAAAKGIYLRKLAVSSTMGGGARVEIASLSAN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RL28_VIBVU
Sequence: MSRVCQVTGKRPAVGNNRSHARNATKRRFLPNLQTHRFWVESEKRFVKLRLTAKGMRIIDKKGIDVVLADMRARGENV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SIAT1_RAT
Sequence: MIHTNLKKKFSLFILVFLLFAVICVWKKGSDYEALTLQAKEFQMPKSQEKVAMGSASQVVFSNSKQDPKEDIPILSYHRVTAKVKPQPSFQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLVTTEKRFLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYILKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNIRC
What is the function of this protein?
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
What are the official names of this protein?
Beta-galactoside alpha-2,6-sialyltransferase 1, Alpha 2,6-ST 1, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, ST6Gal I, ST6GalI, Sialyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Protein: FLA10_ARATH
Sequence: MATSRAFTLFAFTLSLLTVASTVSGHNITQILSDTPEYSSFNNYLSQTKLADEINSRTTITVLVLNNGAMSSLAGKHPLSVVKNALSLLVLLDYYDPLKLHQLSKGTTLTTTLYQTTGHALGNLGFVNVTDLKGGKVGFGSAAPGSKLDSSYTKSVKQIPYNISVLEINAPIIAPGILTAPAPSSAGVSNITGLLEKAGCKTFANLLVSSGVIKTFESTVEKGLTVFAPSDEAFKARGVPDLTNLTQAEVVSLLEYHALAEYKPKGSLKTNKDAISTLATNGAGKYDLTTSTSGDEVILHTGVGPSRLADTVVDETPVVIFTVDNVLLPAELFGKSSSPAPAPEPVSAPTPTPAKSPSPVEAPSPTAASPPAPPVDESSPEGAPSDSPTSSENSNAKNAAFHVNAPALFTALVTIAATSLLL
What is the function of this protein?
May be a cell surface adhesion protein.
What are the official names of this protein?
Fasciclin-like arabinogalactan protein 10.
What is the protein family that this protein belongs to?
Belongs to the fasciclin-like AGP family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: RL32_STACT
Sequence: MAVPKRRTSKTRKNKRRTHIKLAVPGMTECPNCGEYKLSHRVCKNCGLYNGEEVVSK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PSCA_PSESM
Sequence: MKNLGFSKKILLAAALIVVVAFSVFIVINDYRQRQSLKSSVKSELQQLGTLTTQNIQTWLESRIQLLQSMSQQVAVDGKELPQLQRAIGLPTYSDNFQLSYFGSTEGVMFSVPAGNRPADYDPRARGWYKAAQNAPGTIVTEPYIAASSGKLVMTIATPVKIQNQLAGVAGADISLDSVSKIINSLNFDGHGYAFLVSAEGKILVHPDSKLVLKNINEAYPVNTPKIATGVTEIDSGKQPEIISFTPVQGVATANWYVALVLEQDSAYAMLTEFRTSAITAMVVVVMVIILLLGPLIRVLMQPLHQMGRAMRDIADGEGDLTKRLAITSHDEFGALAESFNHFVERIHTSIREVASTAAQLGEVATRVVKVSNASMSNSDQQANRTESVAAAINELGAAAQEIAQNAARTSQQSSDASGLASDGQGVVQQTIKAMNELSGKISESCVNIESLNGKTANIGQILEVITSISQQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLAHRTQDSAQQVQKMIEELQVGAREAVVNMTESQRQSEDSVGIANLAGERLGSVTRRIEEINGMNQSVAAATEEQTSVVESINVDITHINTLNQQGVDNLRQTLEACNSLEEQAARLQQLVGSFRI
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.  PscA recognizes specifically and with high affinity L-Asp, D-Asp and L-Glu.  It exerts a double function, in mediating chemotaxis to these amino acids and in modulating cyclic di-GMP (c-di-GMP) levels, causing alterations in biofilm development.  Plays a key role in the infection process.  It may facilitate bacterial entry into the plant.
What are the official names of this protein?
Methyl-accepting chemotaxis protein PscA, PsPto-PscA.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBC2_FUSSL
Sequence: MSTAARRRLMRDFKRMQTDPPAGVSASPVPDNVMTWNAVIIGPADTPFEDGTFRLVMQFEEQYPNKPPQVKFISEMFHPNVYATGELCLDILQNRWSPTYDVAAVLTSIQSLLNDPNTGSPANVEASNLYKDNRKEYTKRVRETVEKSWED
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.  Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1.  H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.  Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 2, E2 ubiquitin-conjugating enzyme 2, Radiation sensitivity protein 6, Ubiquitin carrier protein UBC2, Ubiquitin-protein ligase UBC2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSD_SALTY
Sequence: MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMTEAQKPDTASYRTFNDFFVRPLRDDVRPLNTDPNILVMPADGVISQLGRIEEDKILQAKGHNYSLEALLAGNYLMADKFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPEGEHEGSVALLKGQEMGRFKLGSTVINLFAPGKVNLIASLASLSVTKIGQPLATSTETFVAPEVEPAPLPAEEIKAEHDASPLVDNKKDDT
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ECCB1_MYCTO
Sequence: MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAALLAYFKPQGKLGGTSLFTDRATNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELSKLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTSPVVQTAVIAMPLEIDASIDPLQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMGPWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRATQAHGLVAPPAMVPSLVVRIAERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQSTVLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSPDPRYTESMYYIDPQGVRYGVPNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP
What is the function of this protein?
An ATPase (By similarity).  Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).
What are the official names of this protein?
ESX-1 secretion system ATPase EccB1, ESX conserved component B1, Type VII secretion system protein EccB1, T7SS protein EccB1.
What is the protein family that this protein belongs to?
Belongs to the EccB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: AMPA_JANMA
Sequence: MDFSIKPLDAKSTIGSIKTGCIAVAVFEDKKLSAGAQALDRKGEISAALKSGDISGKAGSTLLLRGVNGGTTERVLLVGLGKQDAVTEKDFNAAAQAVVRAFTTLGSSEAVIALPFDTVASRDSAWAIRCTILSAREAAYRFDSLKSKKEPTASGVKKIAFAVPAAAVNSAREAVTQAVAVANGIDLTKDLGNFPANVCTPTYLANTAKKMAKEFKLEVEVLDRKQLQALKMGSFLSVTNGSVEPPKFIVLKHNGGKAKDAPTVLVGKGITFDSGGISLKPGAAMDEMKYDMGGAASVLGTMRAIAELKLKLNVIVVIPTCENMPSGSATKPGDIVTSMSGQTIEVLNTDAEGRLVLCDALTYVERFKPAAVVDVATLTGACIVALGHHNSGLFTRNDDAHDALANELLTAGKVAGDTAWRMPIEESYQEQLKSNFADMANIGGPAAGSVTAACFLERYTKKYTWAHLDIAGTAWKSGAAKGSTGRPVPLLTTFLIARAQAAGK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCAN1_PONAB
Sequence: MHFRNFNYSFSSLIACVANSDIFSESETRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAANARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMKRPKPKIIQTRRPEYTPIHLS
What is the function of this protein?
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A.  Could play a role during central nervous system development.
What are the official names of this protein?
Calcipressin-1, Down syndrome critical region protein 1 homolog, Regulator of calcineurin 1.
What is the protein family that this protein belongs to?
Belongs to the RCAN family.
Protein: CWC21_ASHGO
Sequence: MSYNGIGLKTAKGSSTSGHIQRSLADNQAGNVKNFSSRKEESQGRVARASRERKLDGSMAAHADRREIEVRVSELRDELEDADIDAEEIERRCEQLRRQLQSEAAERARVAQAYTPRNARSAGAT
What is the function of this protein?
Involved in pre-mRNA splicing.  May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome.  May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CWC21.
What is the protein family that this protein belongs to?
Belongs to the CWC21 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MERR_SALTI
Sequence: MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSAQRLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLARMETVLSELVCACHARKGNVSCPLIASLQGEAGLARSAMP
What is the function of this protein?
Mediates the mercuric-dependent induction of mercury resistance operon.  In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site (By similarity).
What are the official names of this protein?
Mercuric resistance operon regulatory protein.
Protein: RK32_ARAHI
Sequence: MAVPKKRTSISKKRIRKKNWKRKGYWTSLKAFSLGKSLSTGNSKSFFVQQNK
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS10_TROWT
Sequence: MEEQKIRIRLKSYSHEIIDVSAKKIVDTVTRAGATIVGPVPLPTKKSVVCVIRSPHRHKDSREHFEMRTHKRLINVVDLTPRAVDALMRLDLSSEVNVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ESA1_KLULA
Sequence: MSHGEEKEPGIPQKVDSIDEIFVGCKSWVLKDGQDRLAEILSINSRRDPPKFYVHYEDFNKRLDEWITADRLQIDKEVIFPRPKELEEKKDSKKKKQQQNKSATPQAASATPDGGDVMDLDNLNVQGIPNEDISREDEIKKLRTSGSMTQNQNEVARVRNLNKVIMGKYEIEPWYFSPYPIELTDEDVVYIDDFSLQYFGSKKQYERYRKKCTLRHPPGNEIYRDDYVSFFEIDGRKQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMTRRDELGHHIVGYFSKEKESADAYNVACILTLPQYQRMGYGRLLIEFSYELSKKEGKVGSPEKPLSDLGLLSYRAYWADTLIKLLVEHGQEITIDEVSSISSMTTTDILHTAKALEILRFYRGQHVLYLNSDVMKRYKKLKNNKRRSIDPQKLIWTPPVFTASQLRFAW
What is the function of this protein?
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A. Z (By similarity).  Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity).  The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation.  The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity).  Recruitment to promoters depends on H3K4me.  Also acetylates non-histone proteins (By similarity).  In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
What are the official names of this protein?
Histone acetyltransferase ESA1, Protein 2-hydroxyisobutyryltransferase ESA1, Protein acetyltransferase ESA1, Protein crotonyltransferase ESA1.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Following DNA damage, localizes to sites of DNA damage, such as double stand breaks (DSBs).
Protein: NDK1_SPIOL
Sequence: MEQTFIMIKPDGVQRGLVGEIISRFEKKGFSLKALKFVNVDRPFAEKHYADLSAKPFFNGLVEYIVSGPVVAMVWEGKGVVATGRKLIGATNPLASEPGTIRGDFAIDIGRNVIHGSDAVDSATKEIALWFPDGVVHWQSSLHSWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase 1, Nucleoside diphosphate kinase I, NDK I, NDP kinase I, NDPK I.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
Protein: KBTBC_MOUSE
Sequence: MECKTKGKHQHSLNLLDKIKNMKELEEMIDVVLIAEEEKFPCHRLVLAAFSPYFKAMFTCGLLECTQREVILYDITAESVSVILNYMYSAVLEINNANVQTVAMAAYFMQMEEVFSVCQNYMMDHMDASNCIGIYYFAKQIGAEDLSDQSKKYLYQHFAEVSLHGEILDIEAHQLLALIKSDDLNISREESILDLVLRWVNHNQALRTEHLVELLKQVRLELINASFLRQALRRNTMLLCDGSCIDIIQNAFKAIKTPQQHPSNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSHKTYFISSPKYGEGLGTVCTGVVMENNTVIVAGEATATRLSRQKSKNIEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVDQDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWRERAPMRYSKYRFSAAVVNSEIYVLGGIGCVGRDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTSAGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCLVARMNPRDLIPPPSDLIEEDGDHRGQR
What are the official names of this protein?
Kelch repeat and BTB domain-containing protein 12, Kelch domain-containing protein 6.
Protein: YD271_YEAST
Sequence: MNINYYYCYKSICSWIFLNKLDLPVIYKTSSFDISPACDSMSCSPAIARVEKSLDQKFPIENLDLKSEIPCDSISGGVHFFNINELRTTLTELNAIAKPASIGGRVMPQGMSTPIAIGIMNIL
What are the official names of this protein?
Putative uncharacterized protein YDR271C.
Protein: EIPR1_RAT
Sequence: MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQAGEIWHISASPADKGVLATCYNKTSDSRVQACAAVWRMPKELESGSHESPEDPASTAQTLELLCHLDNGAQGNVACVVWEPMGDGKKVISLADSHILLWDLQPSSSQAVLASSAALEGRGQLKFTSGRWSPHHNCTQVATASDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWSVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDVSDPEEHHTEKSKEPLQDNVIATYEEHEDSVYAVDWASADPWLFASLSYDGRLVINRVPRALKYHILL
What is the function of this protein?
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (By similarity).  Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (By similarity).  Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (By similarity).  Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (PubMed:3172165).  Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (PubMed:3172165).
What are the official names of this protein?
EARP and GARP complex-interacting protein 1, Endosome-associated recycling protein-interacting protein, Golgi-associated retrograde protein-interacting protein, Tumor-suppressing STF cDNA 1 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EIPR1 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network.
Protein: MURC_SYNSC
Sequence: MPRLLDRQTPVHFIGVGGIGMSALARILVDRGHSVSGSDPRDNATTQQLKTLGVKVFRQQDATCIDAVTGRTAADSPVVVISTAIPESNPELQRARQQGLEIWHRSDLLAALIEQQPSIAVAGSHGKTTTSTLITTLLLEADQDPTAVIGGIVPSLGSNGHSGQGKLLVAEADESDGSLVKFSPSLGVITNLELDHTDHYSCLDDLISTLQRFAGGCDRVLANHDCPILQEHFQPTAWWSNQSDESVDFAALPLSLDGDRCVARFYEAGQPVGDFTLPMAGLHNLSNATGALAACRMEGLPFNQLVEGLAGLKAPGRRFDLRGTWKGRHIVDDYAHHPSEVQATLEMARLMVRSGRSPLPSAPQRLLAVFQPHRYSRTRQFLDGFAKALQNCDLLLLAPVYPAGEQPLQGISSNALADRVRKLKPDLEIAVAENLDQLTELVIQHSLENDLVLAMGAGDVNGLWSRLTS
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_STRMU
Sequence: MNHMKRNFEHVKRIVIKIGTSSLVLPSGKIDLNKIDQLAFVISNLMNRELDVILVSSGAMGFGLDILKMDKRPAEVARQQAVSSVGQVAMMSLYSQIFSHYQTNVSQILLTRDVVEFPESLENVTNTFETLLSMRIVPIVNENDAISVDEMDHTTKFGDNDRLSALVANITNSDLLIMLSDIDGLFDKNPTIYDNAVLRENVTEITEEILKSAGGAGSKFGTGGMMSKIKSAQIIFDCDRQMILMNGANPRDILRALDGKMIGTLFAKE
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.