PharMolix/UniProtQA huggingface dataset:
Protein: TRPB_HALH5
Sequence: MTVTYPDERGRFGTFGGKYVPETLMSAIEELELALNDAMNDEAFIHDYKEHLREYAGRPTALTYAKNMSETLGGAKIYLKREDLLHTGAHKLNNAMGQALLAKRMGKKKIVAETGAGQHGVATATIAARFGLECKVFMGEEDMERQALNVFRMELLGAEVVPATSGSKTLKDATNEAIRYWVTHADDTFYLIGSVVGPHPYPQMVRDFQRIIGDEARAQFQEITGTLPTEVIACVGGGSNAIGTFYPFLEDDVKLIGVEAAGKGVETSQHAATITKGRVGVIHGSMTYLLQDDAGQITEPYSISAGLDYPGVGPEHAYLASTGRVKYDAVTDKEALDALKQLSVHEGIIPAVESAHALAKAFERAKQLSQEESILVCLSGRGDKDVHTLMKHFRGEGHE
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: TAUB_BURTA
Sequence: MAKLCAHQVSVVYASRRGALTALENVSMSVGGNEIVVALGASGCGKSTLLSLLAGFQPPTSGRVSVDGAPVTGPGADRGVVFQDDALMPWLNVIDNVAFGLRMQGVGRDARNARARDVLRLVKLAGFEQHRIDEISGGMRQRVGLARALAADPSFLLMDEPLGALDALTREHMQTLLLDVWRETGKGVFLITHSVEEAVLLATELLILSPRPGRIVARHSLDFARRYAAGESMRSIKSDPRFTEIHLALVEQLMRETEEV
What is the function of this protein?
Part of the ABC transporter complex TauABC involved in taurine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Taurine import ATP-binding protein TauB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS18_ACTP7
Sequence: MARYFRRRKFCRFTAENVVEIDYKDIATLKNYISESGKIVPSRITGTRAKYQRQLARAIKRARYLALLPYTDNHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RDH13_HUMAN
Sequence: MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGLEAPSVREQPLPR
What is the function of this protein?
Retinol dehydrogenase with a clear preference for NADP.  Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331).  Has no activity toward steroids (PubMed:18039331).
What are the official names of this protein?
Retinol dehydrogenase 13, Short chain dehydrogenase/reductase family 7C member 3.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localized on the outer side of the inner mitochondrial membrane.
Protein: GDL24_ARATH
Sequence: MKLQILLLALVLIAVEANAVKQGINATIPALIVFGDSIMDTGNNNNLPTLLKCNFPPYGKDYPGGDATGRFSDGRVPSDLIAEKLGLAKTLPAYMNSYLKPEDLLKGVTFASRGTGYDPLTAKIMSVISVWDQLIYFKEYISKIKRHFGEEKAKDILEHSFFLVVSSSNDLAHTYLAQAHRYDRTSYANFLADSAVHFVRELHKLGARKIGVFSAVPVGCVPLQRTVFGGFFTRGCNEPLNNMAKQFNARLSPALDSLDKELDGVILYINVYDTLFDMIQHPKKYGFDVADKGCCGKGLLTISYLCNSLNPFTCSNSSSYIFWDSYHPSERAYQVIVDNLLDKYLSKVY
What are the official names of this protein?
GDSL esterase/lipase At1g58525, Extracellular lipase At1g58525.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted.
Protein: SULP1_CHLRE
Sequence: MERVCSHQLASSRGRPCIAGVQRSPIRLGTSSVAHVQVSPAGLGRYQRQRLQVVASAAAAAAFDPPGGVSAGFSQPQQQLPQQHPRQPQAVAEVAVAESVSAPASAAPSNDGSPTASMDGGPSSGLSAVPAAATATDLFSAAARLRLPNLSPIITWTFMLSYMAFMLIMPITALLQKASLVPLNVFIARATEPVAMHAYYVTFSCSLIAAAINCVFGFVLAWVLVRYNFAGKKILDAAVDLPFALPTSVAGLTLATVYGDEFFIGQFLQAQGVQVVFTRLGVVIAMIFVSFPFVVRTMQPVMQEIQKEMEEAAWSLGASQWRTFTDVVLPPLLPALLTGTALAFSRALGEFGSIVIVSSNFAFKDLIAPVLIFQCLEQYDYVGATVIGTVLLLISLVMMLAVNQLQKLARK
What is the function of this protein?
Part of the ABC-type chloroplast envelope-localized sulfate transporter.  Required for primary uptake and assimilation of sulfate and chloroplast protein biosynthesis.
What are the official names of this protein?
Sulfate permease 1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the ATP-binding cassette (ABC) (TC 3.A.1) superfamily.
Protein: GRXC4_ORYSJ
Sequence: MGMAQSSSSSSRPSDSEQLEEPSKPVMALDKAKEIVASSPVVVFSKTYCPFCARVKRLLAELAASYKAVELDVESDGSELQSALADWTGQRTVPCVFIKGKHIGGCDDTMAMHKGGNLVPLLTEAGAIATPSL
What is the function of this protein?
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase.  Reduces low molecular weight disulfides and proteins (By similarity).
What are the official names of this protein?
Glutaredoxin-C4, chloroplastic, Glutaredoxin-C2 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. CPYC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSY2_SOLLC
Sequence: DPDIVLPGNLGLLSEAYDRCGEVCAEYAKTFYLGTMLMTPDRRRAIWAIYVWCRRTDELVDGPNASHITPQALDRWEARLEDIFNGRPFDMLDAALSDTVSRFPVDIQPFRDMVEGMRMDLWKSRYNNFDELYLYCYYVAGTVGLMSVPIMGIAPESKATTESVYNAALALGIANQLTNILRDVGEDARRGRVYLPQDELAQAGLSDEDIFAGKVTDKWRIFMKKQIQRARKFFDEAEKGVTELSSASRWPVLASLLLYRKILDEIEANDYNNFTRRAYVSKPKKLLTLPIAYARSLVPPKSTSCPLAKT
What is the function of this protein?
Catalyzes the reaction from prephytoene diphosphate to phytoene.
What are the official names of this protein?
Phytoene synthase 2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLSX_SYNJB
Sequence: MRIAVDAMGGDYAPEEIIKGALLAHRQLRVGIALVGRPDSLKPFLPQPLPAGITIVPAEEDVGMAEEPLMVRKKPKASINISMQQVRSNQADAVVAAGNTGAAMAAAYLNLGRLAGIDRPAIGALLPTLKGKPVLLLDVGANVDCRPRFLEQFARMGSLYCQCVLGIEKPRVGLLNIGEEPNKGNDLALATHQRLAQLPGIHFAGNAEGRDVLTGEFDVVVCDGFVGNALLKFAESVGQVITQVLREELPRGWRGKLGCWLLRPNLKQVKRRMDYVEYGGALLLGVNGICVITHGSSKAPMVYHAIRLAKEAAEQKILQRLQAEMVDPREPESNPRRRTRPLQVYSGSGPEVLPLGSLERTSSRCPEPVEDAQP
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: BETB_YERPN
Sequence: MSRYGLQKLYINGAYTDSTSGDTFDAVNPANGECIAQLQAANAQDVDKAVAAAKQGQPVWAAMTAMERSRILRRAVDILRDRNDELAAIETADTGKPLSETRSVDIVTGADVLEYYAGLIPALEGQQIPLRGSAFVYTRREPLGVVAGIGAWNYPLQIALWKSAPALAAGNAMIFKPSEVTSLTALKLAGIYTEAGLPAGVFNVLTGSGDQVGQMLTEHPGIAKVSFTGGIASGKKVMANAAGSTLKDVTMELGGKSPLIIFADADLDKAADIAMMANFYSSGQVCTNGTRVFVPQALQAAFEQKIVERVKRIHIGDPSDERTNFGPLVSFQHRDSVMRYIDSGKREGATLLIGGYSLTEGALAHGAYVAPTVFTHCRDDMQIVREEIFGPVMSILSYQSEEEVIRRANDTEYGLAAGVVTQDLNRAHRVIHQLQAGICWINTWGESAPEMPVGGYKHSGVGRENGISTLEHYTQIKSIQVELGSFNSVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: TGB3_WCMVO
Sequence: MDFTTLVIIGVYLLVFIVYFAKINTSMCTISISGASVEISGCDNPALFEILPNLKPFDHGLSVPSI
What is the function of this protein?
Plays a role in viral cell-to-cell propagation, by facilitating genome transport to neighboring plant cells through plasmosdesmata.  May induce the formation of granular vesicles derived from the Endoplasmic reticulum, which align on actin filaments (By similarity).
What are the official names of this protein?
Movement protein TGBp3, 7 kDa protein, Triple gene block 3 protein, TGBp3.
What is the protein family that this protein belongs to?
Belongs to the Tymovirales TGBp3 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane.
Protein: PYRB_BARBK
Sequence: MTQNTPFPIFPHRHLLGIKGLTLQDLTTLLDRADANVTLYQKNDKKKSILHGRTQINLFFESSTRTQSSFELAGKRLGADVMNMIISNSSVKKGETLIDTATTLNAMNPDILVIRHNCAGAASLLAQKIDCCVINAGDGAHEHPTQALLDALTIRRTKGRIEGLTVAICGDILHSRVARSNIISLNTLGARVRVVAPSTLLPTGIEDMGVEVFHTMQEGLKGADVVMMLRLQLERMTGAFIPSIREYFYHFGLHKENLIYAKNDCIIMHPGPINRGVEIASDIADGTRSMIHTQVEMGIAVRMAIMEALLDPRHDYNGEKK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: KPTA_ACET2
Sequence: MVLIDYSKLSKEVAYALRHAPWEYGLELDAEGWVDINQLLSSLHECEKWKKVSEHDLHVMIEKSDKKRYEISNGKIRALYGHSIPQRIIKEQKCPPEVLYHGTARRFVKSIKEKGLQPQGRQYVHLSADVETALQVGKRRDIKPVLLIVNALEAWSEGIKFYLGNDKVWLADAIPSKYIRFE
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: CD8B_PONPY
Sequence: MRPRLWLLLAAQLAVLHGSSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHSEEVEQEKVAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTPKRRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex.  The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched.  Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs).  Additionally, plays a critical role in thymic selection of CD8+ T-cells.
What are the official names of this protein?
T-cell surface glycoprotein CD8 beta chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Requires the partner CD8A for efficient cell surface expression. The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation.
Protein: CEDA_SALAR
Sequence: MMKPLRQQNRQIISYIPRVEPAPPEHAIKMDAFRDVWILRGKYVAFVLMGESFQRSPAFSVPESAQRWANQVRQENEIAD
What is the function of this protein?
Activates the cell division inhibited by chromosomal DNA over-replication.
What are the official names of this protein?
Cell division activator CedA.
What is the protein family that this protein belongs to?
Belongs to the CedA family.
Protein: RL3_PORG3
Sequence: MPGLLGKKIGMTSVFSAEGKNLPCTVIEVGPCVVTQVKTLEKDGYSALQLGFVDAKEKHTTKPLAGHFKKANVAPKRHLAEFKNFEGEHKLGDVLNVEFFSDADFVDVVGTSKGKGFQGVVKRHGFGGVGQATHGQHNRLRAPGAVGACSYPAKVFKGTRMAGQMGNERVTVQNLEVIKVMPEHNLLLVKGSVPGAKGSILLIEK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: GRPR_MOUSE
Sequence: MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPSATFSLINRNICHEGYV
What is the function of this protein?
Receptor for gastrin-releasing peptide (GRP) (PubMed:1671171, PubMed:1707129, PubMed:9345264, PubMed:12526815, PubMed:26658875).  Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation (PubMed:26658875).  Contributes to the regulation of food intake (PubMed:12176666).  Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain (PubMed:28280205, PubMed:17653196, PubMed:26658875).  Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205).  In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815).  In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (PubMed:34610277).  Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425).
What are the official names of this protein?
Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL7_DEIRA
Sequence: MAYDKQALIDQLGQLTIMELADLIDGLKETWGVTAAVAVSGGGAGAASPAAEEKTEFDVVLIDAGASKINVIKEIRGITGLGLKEAKDMSEKGGVLKEGVAKDEAEKMKAQLEAAGARVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation (Probable).
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: HIS4_RHOCB
Sequence: MILYPAIDLKDGNCVRLLHGEMDKATVFGTDPAAQAAKFEAAGCAWVHLVDLNGAFAGEPVNGAAVEAILARITVPAQLGGGIRDMATIERWLSKGLARVILGTVAVENPDLVREAAKAFPGQVAVGIDARNGKVATKGWATETDVLVTDLAQSFEDAGVAAIIYTDILRDGAMTGPNIEATEALGRAVTIPVIASGGVSSLPDLIALRDTGVIAGAISGRAIYDGALDLQAALAALKA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMA1_DICNO
Sequence: MKSLQKGFTLIELMIVVAIIGILAAFAIPAYNDYIARTQVSEGVSLADGLKIRIADNLQDGDCTTKGDASTGEVGNEDKGKYALATIEGTPAANLSELKAEEKNGCLVKIEYGKGTSGGSVSALINNTELVLAQLANGSYVKESATVKDKFLPKALKETK
What is the function of this protein?
Major component of the type IV fimbriae that plays an essential role in twitching motility, natural transformation, and protease secretion.
What are the official names of this protein?
Type IV major fimbrial protein FimA, Pilin, Serogroup C1.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.
Protein: YA043_HUMAN
Sequence: MKGLRVAKAFQPSQGCSRQALGHLSGRGPSPRSEMNSSVGDLGVGGCSLWDDPARFIVVPAAYALALGLGLPANVAALAMFIRSGGRLGQALLLYLFNLALVDEFFTLTLQLWLTYYLGLARRPPATRPGPPTTCPPMRRWSSPRSSACAAAASYAVPGPGRLPAWPGAYGAPRALPAPSPGWRAWPLPAWSTAGQARGWPPPRWPSRPPSCWCSRPT
What are the official names of this protein?
Transmembrane protein LOC653160.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YQGF_PARDP
Sequence: MICENVETFAEALPRTGAVAGLDLGTKTIGVAVSDGLRGVASPLTVIRRTKFTADAQALLKIVQDRALVGLVLGLPRNMDGSEGPRAQSTRAFARNLERLTPLPITFWDERLSTVAAERALLEGDTSRKRRAEVIDQVAAGYILQGALDRLRFLGRTE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANR65_HUMAN
Sequence: MDSQRPEPREEEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQALPELGGGEKECEGIESTG
What are the official names of this protein?
Ankyrin repeat domain-containing protein 65.
Protein: MNMA1_CLOBK
Sequence: MSKGTVALAMSGGVDSSVSAYILKERGYDVIGIYMDLWRDEREEYCNKSAAEDARRVAEKLDIPFHVINIEKKFKDNVIDYFIDEYLSGRTPNPCVACNRTIKFEAFFNAAKEFGADFMATGHYCKIEERNGRKVIVKAEDDKKDQTYMMYNLKQYQLERTIMPCGEYKKDYIREIAENIGLDVYNKKDSQEICFIPDNDHGGFIKRNYKSKVSEGNFVDKKGNIIGKHKGIIYYTIGQRKGLGIALGKPAYVIDINPITNEVVIGDEEDIFRTELIARDVNFIPFDKLEKSMELEAKVRYSAKPSKATIIPLENNKVKVVFQNKQRAITKGQSVVFYDKDMLVGGGIIEEIV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA 1.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_STRM5
Sequence: MSKRDYYEVLGVARTANDEELKKAYRRCAMKFHPDRNPGDAAAEASFKECKEAYEVLSDGNKRRMYDSHGHAAFEHGMGGGGGPGGPDMNDIFGDIFGNIFGGAGGGGPRQARRGADIGYVMELDLEEAVRGVERRIEIPTLAECGDCDGSGSEDGKVETCNVCHGRGQVRIQRGIFAMQQACHNCGGRGQIIAKPCKTCHGNGRVEEDKVLSVKVPAGVDTGDRIRLSGEGEAGPAGTPPGDLYVEVRVREHAIFQRDGDDLHCEVPIRISQAALGDTVRVATLGGEAEIRIPAETQTGKLFRLRGKGVRSVRSRSEGDLYCRVVVETPVNLTNDQRKLLEQFEATFNGEDARKHSPKSATFIDGVKGFWDRMTS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBLN2_HUMAN
Sequence: MVLLWEPAGAWLALGLALALGPSVAAAAPRQDCTGVECPPLENCIEEALEPGACCATCVQQGCACEGYQYYDCLQGGFVRGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCVHAGHKYAAGHTVHLPPCRACHCPDAGGELICYQLPGCHGNFSDAEEGDPERHYEDPYSYDQEVAEVEAATALGGEVQAGAVQAGAGGPPAALGGGSQPLSTIQAPPWPAVLPRPTAAAALGPPAPVQAKARRVTEDSEEEEEEEEEREEMAVTEQLAAGGHRGLDGLPTTAPAGPSLPIQEERAEAGARAEAGARPEENLILDAQATSRSTGPEGVTHAPSLGKAALVPTQAVPGSPRDPVKPSPHNILSTSLPDAAWIPPTREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPEGSTKDLIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEMKLWRQGSVTTFLAKMHIFFTTFAL
What is the function of this protein?
Its binding to fibronectin and some other ligands is calcium dependent.  May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
What are the official names of this protein?
Fibulin-2, FIBL-2.
What is the protein family that this protein belongs to?
Belongs to the fibulin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TMP_BPMU
Sequence: MTGKRLKASVIIDLNGNLSRRSRQYSNQINALSRSGQSSLRALRMEVVRVSGAIDRMGSLSTRTFRMLSAGALGIAGVGYTANKLFIGAAAQREQQIIAMNSLYHGDKVRAQAMMAWAKQNAKDTTWGLSGVLDEIRSSKGFGMTDEQTKQFITMLQDQGAMHGWDLPTAQGASLQLKQMFARQQITAADANLLTGYGINVYQALADATGTDVKKIRDLGTKGKLGMKSILTVFRTLSEQSKGAQASAMNSWDGMFAQMEANLLEFRIKVANSGPFEEIKNEMRRVLNWHDMADKSGELDALAENIGQKFLTTFRTVKISAQELWRWLKPGKDALAWVDQNIVSLKKLAAVLVSVWLANKALRAGWAVAKPSWQVASYPFKTGRRMWRWMRNRKRGQAGLPVPDAMTSETLLQGIGIQRVFVINWPRGFGDYGSGGGRRVRSGGRMAPLLPRQPLLLSGPQPLALPAPRPVLALPPPGVPVTARPAPLPLPGKSGLLSRLAGSAAGQLVTGTVGKLADAGRAVGGWFSGIGNKLAGSAIGRVVTKGAGALGWMGKGAGRALSRLGGPVMGALQLAPVLMDEQASTHEKAGAIGSTAGAWLGGAVGSLAGPLGTVAGATLGSVAGEYLGGFVTDLYQKWTATDKEPQEQKVNAEASLRVELGEGLRLTSSRVTEDGMGLNIYAGDNYITGW
What is the function of this protein?
Serves as a base for tail tube protein polymerization and acts as a template for tail length determination.  Might remain in the tube and be ejected from the tail prior to the DNA during DNA ejection (Potential).
What are the official names of this protein?
Probable tape measure protein, TMP, Gene product 42, gp42, Gene product Y, gpY.
What is the protein family that this protein belongs to?
Belongs to the Mulikevirus tape measure protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: KCY_STAAB
Sequence: MKAINIALDGPAAAGKSTIAKRVASELSMIYVDTGAMYRALTYKYLKLNKTEDFAKLVDQTTLDLTYKADKGQCVILDNEDVTDFLRNNDVTQHVSYVASKEPVRLFAVKKQKELAAEKGIVMDGRDIGTVVLPDADLKVYMIASVEERAERRYKDNQLRGIESNFEDLKRDIEARDQYDMNREISPLRKADDAVTLDTTGKTIEEVTDEILAMVSQIK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDD_ECOSE
Sequence: MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLAAACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLPDAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHSIDRVLLA
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.