PharMolix/UniProtQA huggingface dataset:
Protein: GATC_BIFAA
Sequence: MPTFTKEEIVHLGDLARIALTDEEITRLQGDLNVIAESINKVQEVATDDVEPTANPVPLEAYLRPDVPETPLTQAEATAGAPVSEAGMFVAPRILGQE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: IF2_PARD8
Sequence: MPIKLIQVQRKLNVGINTVVEFLHRNGFSVEDNPNTRISDEQYALLVKEFGKDLPEKDRNFAADRMRKEVPSVKEEKTAEIKTVIPEEFRPKIVMKGHIDLDGGQHKKQQEEPKAKEEPKVKEEPKVKEEPKVKEAPAAPAAQAPVKPAQPAQAPTEKKEEKVIVVEVEKEKTVEKQPVVAEPKVESVKPEQEVEKTEEKDDNLFRLNSVKLESKIKVTGKIDLDALNQSTRPKKKTKEEKRKERDEKQKFNNNRPGNNSNGPGAPHKSPNSPTLIKPNAPAKPGEEGDAKKKRKRIKKDRVDVNNTPGTNYPRPNRDDRPNNDRKPRLKKPVKAEVSEEDVQKQIKETLARLTNKNNKNNKGAKYRRDKRDAAVKREHELMEQEELESKVLKLTEFVTANDLANMMDVSVTEVIGTCMSIGLMVSINQRLDAETINIVAEEFGYKTEYVSADVVEAINADEEDDNEEDWVARPPIVTVMGHVDHGKTSLLDNIRSANVIAGEAGGITQHIGAYNVKLQNGRRITFLDTPGHEAFTAMRARGAKVTDIAIIIVAADDNVMPQTIEAINHASAAGVPIVFAINKIDKPHANPEKIKEELANMNYLVEDWGGKYQSQEISAKKGIGVEELLEKVLLEADLLDLKANPKKRAVGSIIESSLDKGRGYVSTILVENGTLKMGDIVLAGTHQGRIKAMFNERNQRVEKAGPSEPVLILGLNGAPQAGDTFNVLETEQEAREIANRREQLQRELGLRTQKMLTLDDIGRRIAVGNFQELNVIVKGDVDGSVEALSDSLIRLSTEEIQVNVIHKAVGQISESDVVLAAASNAIIIGFQVRPSLQARRNAEKEGVEIRLYSIIYDAIEEVKSAMEGMLSPEIKEEITAYVEVQQVFKITKVGTVAGCMVKEGKIKRTNKIRLIRDGIVIYAGELGSLKRFKDDAKEVVAGLDCGLNITNFNDIQVGDMIEAYEETEIKKTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_STAAN
Sequence: MFNQSYLNVYFICGTSDVPSHRTIHEVLEAALKAGITLFQFREKGESALKGNDKLVLAKELQHLCHQYDVPFIVNDDVSLAKEINADGIHVGQDDAKVKEIAQYFTDKIIGLSISDLDEYAKSDLTHVDYIGVGPIYPTPSKHDAHIPVGPEMIATFKEMNPQLPIVAIGGINTNNVAPIVEAGANGISVISAISKSENIEKTVNRFKDFFNN
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: SYK_MALP2
Sequence: MERKFNDQELIRREKLKNLQEANQDPYEIEKVSRTMTIGDFNSKFAKLKTHNTNNNIKLAGRVVALRQTFGVIRDFYGDTQFYLNKKKVSKSMLEYFNKVLDLGDIVEIFGSPFRTQKGELTLDVKKIKIVSKALKPLPEKWHGLEDEELRARHRYVDLIVNKDSMKVFVDRIRILKIIRQFMDSQNYLEVETPVLHPILGGANARPFITFHNTLERNFYLRIATELPLKKLIVGGFDKVYEIGRIFRNEGMDSTHNPEFTSMEVYAAYENMEYMMRLTENLFKYVAKSLKKPVVKMGENEIYLTQKFRRIHMVDFIKQETGVDFWEVKSNQEAQELAKKHNVKFEKHQSTLGHIINLFFEEFCEAKCIQPTFVYGHPIDVSPLSKKDYKNPGFTKRFELFINTKEYANAFAELNDPIDQYERFEAQVKEKSLGNDEAVEMDMDFIEALEYGLPPTAGLGVGIDRMIMLFTEKSSIRDVLLFPHMKDKK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERFB_KLULA
Sequence: MIERFMRNDKDRPSARDGQQNGTNDDSYFVKFLHWIITLDTYDGSSRNYGRMTETTNYTFFFGGRVRTVTKTSVYSIVVFAMFIVPLILFSIFECNYLWHHKGTNWKPAIVILYYFYLLTICSFLRAACSDPGIVPRNVHIPDLNASYKIPQEYYNYAILPTKNPNASVSMKYCQTCRIWRPPRSAHCSVCDVCVLSHDHHCKWLNNCIGKRNYRFFLEFLMASTISCILLILLSSFRLSYSPQVRYTPVSLLIICYCGLGIWYPLILFIYHIFLAGTQQTTHEYLRSIGSKHPIFHKITRNRDSPYDRNSMFFNLIHLWFQERGWNLVDPRRKQHYPADIRFRKLPEAHSFETV
What is the function of this protein?
The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.
What are the official names of this protein?
Palmitoyltransferase ERF2, DHHC cysteine-rich domain-containing protein ERF2, Ras protein acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SODC_DROVI
Sequence: MVVKAVCVINGDAKGTVFFEQEGEGCPVKVTGEVTGLAKGQHGFHVHEFGDNTNGCMSSGPHFNPYQKEHGAPTDENRHLGDLGNIIANGDGPTPVNICDCKITLLGANSIIGRTVVVHADPDDLGKGGHELSKTTGNAGARIGCGVIGIAKI
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn], Superoxide dismutase 1.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTA_XENBS
Sequence: MKNKRRTYFFQFAVLAVVIATAYFAWNYFKASTISEEKSAQASKSLQDLKYLLQPPVQVATAKIQSVPHYLGGLGTVQAANTVTVTSLVAGQLTALHFDEGQFVKQGDLLAEIDPRSFQIQLAKVQGQYAKDQATLANSRQDLVRYQQLAKNKSISQQDLDKQISTVRQYEALLKADQSSIDDARLQLTYSRITAPISGRVGLKKIDVGNYISAGGGTPLVIITQVDPIDVLFALPENDISAVLKAQKNNKDVVVTAWDRNNQQQLAQGKLLSIDNLIDVTTGTIKMKARFDNQNNVLFPNQFVNIQIKVNTLENAIVIPNAALQMSSEGHYVWKVDKENKVNKRKVTIGLQNAQLVVISKGLATGDRVVTDGTDALTEGTGITIVKPLKSESANTYDQMDKSKPSNSKVENT
What are the official names of this protein?
Multidrug resistance protein MdtA, Multidrug transporter MdtA.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VIE1_HCMVM
Sequence: MESSAKRKMDPDNPDEGPSSKVPRPETPVTKATTFLQTMLRKEVNSQLSLGDPLFPELAEESLKTFEQVTEDCNENPEKDVLTELVKQIKVRVDMVRHRIKEHMLKKYTQTEEKFTGAFNMMGGCLQNALDILDKVHEPFEDMKCIGLTMQSMYENYIVPEDKREMWMACIKELHDVSKGAANKLGGALQAKARAKKDELRRKMMYMCYRNIEFFTKNSAFPKTTNGCSQAMAALQNLPQCSPDEIMSYAQKIFKILDEERDKVLTHIDHIFMDILTTCVETMCNEYKVTSDACMMTMYGGISLLSEFCRVLCCYVLEETSVMLAKRPLITKPEVISVMKRRIEEICMKVFAQYILGADPLRVCSPSVDDLRAIAEESDEEEAIVAYTLATAGASSSDSLVSPPESPVPATIPLSSVIVAENSDQEESEQSDEEQEEGAQEEREDTVSVKSEPVSEIEEVASEEEEDGAEEPTASGGKSTHPMVTRSKADQ
What is the function of this protein?
Plays an important role in transactivating viral early genes as well as activating its own promoter, probably by altering the viral chromatin structure (By similarity).  Expression of IE1 and IE2 proteins is critical for the establishment of lytic infection and reactivation from viral latency (By similarity).  Disrupts PML-associated ND10 nuclear bodies by interfering with host PML and SP100 sumoylation thereby altering the regulation of type I and type II interferon-induced gene expression (By similarity).  Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones (By similarity).  In addition, functions in counteracting the host innate antiviral response (By similarity).  Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2 (By similarity).  Also targets type II interferon pathway by repressing IL6- and STAT3 target genes (By similarity).  Repression of STAT3 genes is due to STAT3 nuclear accumulation and disruption of IL6-induced STAT3 phosphorylation by IE1 (By similarity).  This repression is followed by phosphorylation and activation of STAT1 (By similarity).  Inhibits host ISG transcription by sequestering host ISGF3 in a PML- and STAT2- binding dependent manner (By similarity).  Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters (By similarity).
What are the official names of this protein?
Immediate early protein IE1, IE1, 55 kDa immediate-early protein 1, IE1p72, IE72.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 IE1 protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=Colocalizes with host PML-associated nuclear bodies very early post infection.
Protein: RL17_BACAC
Sequence: MAYRKLGRTSAQRKAMLRDLATDLIINERIQTTETRAKELRSVVEKMITLGKRGDLHARRQAAAFIRNEVANAETGQDALQKLFADVAPRYAERQGGYTRIAKIGPRRGDAAPMVIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: CSP2_LACPL
Sequence: MKNGTVKWFNADKGFGFITGEDGTDVFVHFSAIQTDGFKTLDEGQKVTYDEEQGDRGPQATNVQPQ
What are the official names of this protein?
Cold shock protein 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_SALNS
Sequence: MLNSAMSVVILAAGKGTRMYSDIPKVLHTLAGKPMVQHVIDAATKLGAAQVHLVYGHGGELLKQTLKDDKLNWVLQAEQLGTGHAMQQAAPFFSDDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPSGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADLKRWLSKLTNNNAQGEYYITDIIALAYQEGREIAAVHPARISETDGVNNRLQLSRLERIYQAEQAEKLLLSGVMLRDPARFDLRGTLHCGMDVEIDANVIIEGYVTLGHRVKIGAGCIIKNSVIGDDCEISPYSVVEDAHLEAACTIGPFARLRPGAELLAGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTVIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVADNELVLSRVPQVHKQGWQRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD1_PIG
Sequence: MEEKLKKSKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSARGKMLSEIMEKGQLVPLETVLDMLRDAMVAKVDTSKGFLIDGYPREVKQGEEFERKIGQPTLLLYVDAGPETMTKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDDVFSQVCTHLDTLK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:2551297).  Exhibits nucleoside diphosphate kinase activity, catalyzing the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and dTTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor (By similarity).  Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (PubMed:2551297, PubMed:2551298).
What are the official names of this protein?
Adenylate kinase isoenzyme 1, AK 1, ATP-AMP transphosphorylase 1, ATP:AMP phosphotransferase, Adenylate monophosphate kinase, Myokinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_METKA
Sequence: MKVAIVEYGVGNLNSVYRAVKHLGHEPVVTDDPSELHDADAVILPGVGNFRAAAEKLEETGLCDEIRELLGSVPLLGICLGMQLLMESSEESPESRGLGVFRGTCVALPNDVKTPHMGWNTVEFRTEEFREFDGEMFYFVHSYRVAPEDDVVLGETEYGERFPSVIGDRGRLIYGMQFHPEKSGPVGLKLLGEVLTGASR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNFB_SALTY
Sequence: MNNTLSKRLCLTAMLTLAAVVYTTSAFAETSKLVIESGDSAQSRQEAAMEKEQWNDTRSLRQKVNTRAEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVITP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: CMOA_CAMJJ
Sequence: MKDELFKQSPKKQFEFDKSVASVFDDMINRSVPFYRENLELCGNLLAKILSTNASVCDLGCSSANFLIFLANLRKDFKLFGVDNSASMLEVAKSKAKAYGLDISFFEANLCEFDFFVCDVFVANYTMQFIRPPKRQELLDKIYKNLNSKGILIMSEKILYEDAFLSKNIIELYADYKEKQGYSKFEIAAKREALENVLIPYSQKENLNMLEKAGFKKIESIFKWANFETFIAFKD
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: UXUA_THESQ
Sequence: MKLVFRWYGEKHDTVTLEQIRQIPGVEGVVGALFDIPVGEVWPLEEIMKLKETVEKAGLKLEVIESVNVHEDIKLGLPTRDRYIENYKETIRNLAKAGVKVVCYNFMPVFDWMRTDLHKKLPDGSETMEYDHRLIEGVTPDELIKRVKEGSQGFVLPGWEWDRLEKLRETFELYKNVDEEKLFENLVYFLERVIPVCEECDVKLAIHPDDPPWSIFGLPRIITNKENIERMLKAVDSPYNGITFCMGSLGANPENNIPEMIRYFGKMGRIHFAHVRNLKFTGEKSFYETAHPSFCGSHDLFEVMKAFHDIGYEGYIRPDHGRLIWGEKARPGYGLYDRALGATYILGLWEAIDKMKKRYC
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: RK36_BUXMI
Sequence: MKIRASVRKICEKCRLIRRRGRIIVICSNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLPD_STAS1
Sequence: MSLSTLKREQIKKDLKDQEFDVVIIGGGITGAGIALDASERGMKVALVEMQDFAQGTSSRSTKLVHGGLRYLKQLQVGVVAETGRERAIVYENGPHVTTPERMLLPMHKGGSMGKFTTSIGLAMYDRLAGVKKAERKTMLNAKETLEKEPLVKKAGLKGGGSYVEYRTDDARLTIEVMKRAEEKGAKVINHTKSVHFTYDSNEKVNGIQVEDQISNETYPIKAKKVINASGPWVDEVRSGDYARNNKQLRLTKGVHIVIDQSKFPLGQAVYFDTEKDGRMIFAIPREGKAYVGTTDTFYDNNKTSPLANQEDRDYLIDAINYMFPDVNVADEDIESSWAGVRPLILEEGKDPSEISRKDEVWEGKSGLLTIAGGKLTGYRHMALEIVDLLSKRLKSEFGLKFDKCATKHLTISGGDVGGSANFDKFIEQKVEEAKSYQIDESTARHFASKYGSNAEELFKIAQTAQYQETGLPLDIYTELVYSIQNEMVYRPTDFFIRRTGKLYFKIDDVLNYKEQVIDVMAGLLGYTNIEKEAYTKELQIAIDEAQTGNHQPAVKE
What are the official names of this protein?
Aerobic glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEC1_HUMAN
Sequence: MTMNVLEAGKWKSIVPAPGEGLLAVLHMMVFTDALHRERSVKWQAGVCYNGGKDFAVSLARPKAAEGIAD
What is the function of this protein?
Candidate tumor suppressor.
What are the official names of this protein?
Deleted in esophageal cancer 1, Candidate tumor suppressor CTS9.
Protein: MICA2_HUMAN
Sequence: MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPDEPTSPKRPKSISEPQHSDAEGDAASPLPSEWTSVRISPGEEAAGQDVLAVRVLVTSEDSSSDTESDYGGSEGSHTEPCEEKPWRPGSPHLPHTSLGEALSRAVSPQCPEEPRAVHAALQRANSFQSPTPSKYQNWRREFWWSLTPVNKRTMSPPKDPSPSLPLPSSSSHSSSPPSSSSTSVSGNAPDGSSPPQMTASEPLSQVSRGHPSPPTPNFRRRAVAQGAPREIPLYLPHHPKPEWAEYCLVSPGEDGLSDPAEMTSDECQPAEAPLGDIGSNHRDPHPIWGKDRSWTGQELSPLAGEDREKGSTGARKEEEGGPVLVKEKLGLKKLVLTQEQKTMLLDWNDSIPESVHLKAGERISQKSAENGRGGRVLKPVRPLLLPRAAGEPLPTQRGAQEKMGTPAEQAQGERNVPPPKSPLRLIANAIRRSLEPLLSNSEGGKKAWAKQESKTLPAQACTRSFSLRKTNSNKDGDQHSPGRNQSSAFSPPDPALRTHSLPNRPSKVFPALRSPPCSKIEDVPTLLEKVSLQENFPDASKPPKKRISLFSSLRLKDKSFESFLQESRQRKDIRDLFGSPKRKVLPEDSAQALEKLLQPFKSTSLRQAAPPPPPPPPPPPPPPTAGGADSKNFPLRAQVTEASSSASSTSSSSADEEFDPQLSLQLKEKKTLRRRKKLEKAMKQLVKQEELKRLYKAQAIQRQLEEVEERQRASEIQGVRLEKALRGEADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELELEDHQSRLEQKLREKMLKEESQKDEKDLNEEQEVFTELMQVIEQRDKLVDSLEEQRIREKAEDQHFESFVFSRGCQLSRT
What is the function of this protein?
Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334, PubMed:29343822).  Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network (PubMed:34106209).  Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription.  Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).
What are the official names of this protein?
[F-actin]-monooxygenase MICAL2, MICAL C-terminal-like protein, Mical-cL, Molecule interacting with CasL protein 2, MICAL-2.
What is the protein family that this protein belongs to?
Belongs to the Mical family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TGT_STRPZ
Sequence: MTDYPIKYRLIKTEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKAIGSGIILSNTYHLWLRPGDELIARSGGLHKFMNWDQPILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAADLVAMDFPGYSIGGLAVGESHEEMNAVLDFTTPLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSEGRLVVKNAKFAEDFTPLDHDCDCYTCQNYSRAYIRHLLKADETFGIRLTSYHNLYFLVNLMKKVRQAIMDDNLLEFRQDFLERYGYNKSNRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PROQ_ECO57
Sequence: MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVDRVAGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELDEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAAAAGEKEDAPRRERKPRPTTPRRKEGAERKPRAQKPVEKAPKTAKAPREEQHTPVSDISALTVGQALKVKAGQNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOC2_TAPIN
Sequence: MGARHLLALLLVLLVLGFEVQGAQVPQQDEAANTTLLTQVQESLLSYWDSTKAAAQDLYKKTYLTTMDEKIRDMFSKSTAAVSTYVGIFTDQLLSLLKGDE
What is the function of this protein?
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma.  Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.  Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
What are the official names of this protein?
Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ANF_TAKRU
Sequence: MTALVLWGLLLLLGQHTQVNSHVLGRPFSASDSSQLKSLLERLEETISEADQEQNPELDQEVEYDIRDQDPGQRWNLDLGRDQDQVTATRSEIHSRPSVQRSHLQDLLMSLRKRASSCFGARMDRIGNASGLGCNNGRG
What is the function of this protein?
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation.  Has a cGMP-stimulating activity (By similarity).
What are the official names of this protein?
Natriuretic peptides A, Prepronatriodilatin.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBIC_ECO55
Sequence: MSHPALTQLRALRYFKEIPALEPQLLDWLLLEDSMTKRFEQQGKTVSVTMIREGFVEQNEIPEELPLLPKESRYWLREILLCADGEPWLAGRTVVPVSTLSGPELALQKLGKTPLGRYLFTSSTLTRDFIEIGRDAGLWGRRSRLRLSGKPLLLTELFLPASPLY
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADA21_HUMAN
Sequence: MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDDRALLEDQLFIPDDCYYHGYVEAAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKINSNETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYKQLGTYIILIGIEIWNQGNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETKAHSSG
What is the function of this protein?
May be involved in sperm maturation and/or fertilization.  May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 21, ADAM 21.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.