PharMolix/UniProtQA huggingface dataset:
Protein: BIOD2_HAEIN
Sequence: MGKVIFISGIDTDVGKTIATGIYAKKLMEQGCSVITQKMIQTGCKNIADDLLVHRKIQGIDLTEEDLQGKTCPYVFEYPCSPHLAAKRESRKIEAKIIEKSTALLAEKYDYVLLEGAGGLMVPYCEEATTLDYIQLNNYPLILVTSGKLGSINHTLLSLEACRTRGISVLSVMYNGYPEYDLLLVKKPNAI
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD 2, DTB synthetase 2, DTBS 2, Dethiobiotin synthase 2.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SET1B_XENTR
Sequence: MSFKEAKPGERGKNPEDHGRKQTASWINGMEAGNQPSTSGEKKSHHWRSYKLIIDPALRKGQHKLYRYDGLSFSMPNSGVPPVDSVRDPRIGRIWTKTKELDLPVPKLKIDEFYVGPVPPKQVTFAKLNDNIRENFLGDMCKKYGEVEEVEILYNPKNKKHLGIAKVIFASVKGARDAVKHLHNTSVMGNIIHVELDTKGETRMRFYDLLVNGFYTPQTLPVGSDLDASPTVNETPQVVESVKRTKETAIGPSVTPNSSTPFSHDTAYSSSRQGTPNSYSQFTPQSQGTPHTPRLGTPFSQDSSYSSRQTTPAFHYGQDSGFKPRRHENKFTDAYNRRPGHHYVHSSGSYRGTEHTFNVTRPQPEPVQVPRTPPLSHSSGNYKSAFSPYQGNTVFPQTDESQYPQTSRDMEYRRTGPQTSDSYSDAGCNSASLELKPVKEKPEEPPPPEPDSTTEQKASFSQTPERCETPGTPTLEAELQHNSLDTRIAMLLKEQRTQLHLIAGDQNSDNEIRMEGSPISSSSSQLSPIPPYSSGSRYQDVTPSSRPSSTGLEDISPTPLPDSDDDDEPIPGTASLCQNSRSASPIDQINQSGRKTESLDKKELVAGDETPTSEKMDEGHPSSGEDMEISDDEVTPSPITSAECAITSSSVISSVIPIPPPGFPPLPPPPPPQPGFPMPPPLPPPPPPTHPSVTVPPPPLPAPPGVPPHHILHHPPPYHHFPVMQGEMMNVLGNHWGGMTMSFQMQTQMLSRMMQGQGSYPYHHFMGGSMQFGNQHPYRPFAISAHLTRGQPWPPFPKFDPSVPPPGYEHKKEDPHKATVDGVLQVIVKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERLAKQSLTPVKSGESKEEDKQKTKEHITSSLLESWNKGEGLGFEGIGLGIGLRGAIRLPSFKVKRKEPPDAALAGDQKRIRPSHSVDDEDEESERDRDISSTASDLSKKDADAVNNRRRPARPLDSEGEEEVESEGDDGETSDKEDSSSEKEDQDDGSVSALSSKKQLYGDKEGDDEDDDTQSSGKEEDLVSEEEDTTSVASSRAEMDSSDESEESSEYESSSDSDEKEEEDDEEEELVFGDDQSEDQDLGQEYEVETDREEDFFRENLSECSSLPKAGDVELEDEMQKVEEDVARQTTQETLHLRKKNLDVPLVESKECKQDTLDKVEKLFAVPMQEEVFKEHEKAPSPMNEEEEYIELQLEPVPLVPEGAAPAAQEPVIIRPLTPTGAFGETGPVLKLEEPKLQVNLTQFATEDEELYPRTPGRDTAAHSDTEVTFQPGLKVAPSSLPFLPSHNKEEECLLPPEKHAGHLTVTKMLSEEDLPRTPGRDIVVKSSHLGKSQSTETVPATPGSDAPLTGSSLTLTSPHIPGSPFSYLSQSPGIINSGIPRTPGRDFNFTPTFPESNSIFPCHPSGKKPSVDEPDEKSFKEPTSASLTMNSVPSPIPFASPPRGLPHMDIRLGADDLESSDTPAYLSDKLLSEESECEFTKVHLTSTDESAPSPPLPPAEKRKGDRSKKPLSAHEFETEKNYETSSAVAMSEGALGKQMFIGQPDAVSGIKDPAAVPLDFRNDSLSENTVHEPIIQKVPLKELENQWNEVLKEEEDITKHKKSRNSRHNNRYDEFSTVPSPEFSPPRAMFKPRSEFEEMTILYDIWNGGIDDEDIKYMCITYDRLLQQDNGMDWLNDTLWVYHPSTSVYSPKKKKRDDGLREHVTGCARSEGYYKIDKKDKLKYLINNRSLTEELPIDTQGKSIPAQPQASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLRFCKSHIHDWGLFAMEPIIADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQYINVNEEITYDYKFPIEDVKIPCLCGAENCRGTLN
What is the function of this protein?
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.  H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
What are the official names of this protein?
Histone-lysine N-methyltransferase SETD1B, SET domain-containing protein 1B.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus speckle. Chromosome.
Protein: BCHL_METSB
Sequence: MNIPLRIGGCASGPGCGDGEGSVQVATDPLLAIETAKVFAVYGKGGIGKSTTSSNLSAAFSKLGKRVLQIGCDPKHDSTFTLTKRFVPTVIDVLESVNFHAEELRAEDFIFEGYNGVMCVEAGGPPAGAGCGGYVVGQTVKLLKAHHLLEDTDVVIFDVLGDVVCGGFAAPLQFADRTLIVCANDFDSIFAMNRIVAAIASKAKNYKVRLGGVIANRSAELDQIDNYNNRVGLKTMAHFRDLDAIRRSRLKKSVIFEMDPSPEILAVQAEYMHLAETLWAGTEPLDAMPLKDREIFDLLGYD
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: RS8_BACVZ
Sequence: MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIADILKREGFIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLGIAIISTSQGVLTDKEARAKQAGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ISPD_CORGB
Sequence: MSSTRIPVIALLAAAGRGTRLGGPIPKAFVTLRERTLLERSLQAMLTSESVDEIIILVSPDMETYARDLLRKRGLLNDPEGVRIRLVHGGGERADSVWAGLQAILLDDATPDAIVLIHDSARALTPPGMIARVVRKVHEGATAVIPVLPVSDTIKRVSLDAGVVVDTPNRAELRAVQTPQGFLLSELVAANKKFFADPNPGFIPTDDASLMEWYGADVVCVQGDPMAFKVTTPIDMMLAQRITDEAEPTIFEVPGD
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: FRIH_FELCA
Sequence: MTTASPSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWENGLNAMECALHLEKSVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKSIKELGDHVTNLRKMGTPESGMAEYLFDKHTLGNSDSES
What is the function of this protein?
Stores iron in a soluble, non-toxic, readily available form.  Important for iron homeostasis.  Has ferroxidase activity.  Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.  Also plays a role in delivery of iron to cells.  Mediates iron uptake in capsule cells of the developing kidney (By similarity).
What are the official names of this protein?
Ferritin heavy chain, Ferritin H subunit.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.
Protein: CYSC_SALCH
Sequence: MALHDENVVWHSHPVTVAAREQLHGHRGVVLWFTGLSGSGKSTVAGALEEALHHRGVSTYLLDGDNVRHGLCRDLGFSDADRQENIRRVGEVASLMADAGLIVLTAFISPHRAERQLVKERVGHDRFIEIYVNTPLAICEQRDPKGLYKKARAGELRNFTGIDAIYEAPDSPQVHLNGEQLVTNLVSQLLDLLRRRDIIRS
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: CENPK_SCHPO
Sequence: MNSENASLFRNILNDTENLVQPLTQDESRLALFESLVQSDQLLVEKIEKWEKKVSKFTENSKSEKRKLQLELFQEIIDLKKCIAFKPIIGKNAIDNNISDLKKNLHSNKKLEAVLKEELHQIKKFSSDLQSLKSSMGERQKQQAAMSRRGKKSIIHSAIIQEKERYEKESQELFTFLDGFLDEHAPSLLEGAQASIDKNRPGKNQPSLNFENISKKDLTEEFKQVIENLMNNSIIPGSPYIEVKNERIVSFLVLASLCTVDPQDPSKVKLIPFSDEI
What is the function of this protein?
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis.  Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
What are the official names of this protein?
Inner kinetochore subunit sim4, CENP-K homolog, Constitutive centromere-associated network protein sim4, Silencing in the middle of the centromere protein 4.
What is the protein family that this protein belongs to?
Belongs to the CENP-K/MCM22 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Associates with the central core region of the centromere.
Protein: STS1_POSPM
Sequence: MSSSAPSTSAPTKIVIPDLVSHCTIPVRCNRHWKQASVESKRWLFRGGNLSDRKRDAFHGLKAGYLTSMCYPLAGYPQLRVSCDFMNYLFHLDNISDEMNDRGTHGTAVSVLDALYQPHMHPTSRVGKMTKDYWVRLIQTASPGAQQRFIETFDMFFQAVTQQAMDRANGVIPDLESYIAIRRDTSGCKPCWALIEYANNLDLPWEIMDHPIIRGLGEAANDLVTWSNDIFSYNVEQSKGDTHNMIVVVQNQQGLDLQSAVNFVGDLCKQSIDRFHYLRENLPSWGPELDREVEIYVDGLADWITGSLKWSFESERYFGKAGLEVKKTRVVALLPRRA
What is the function of this protein?
Terpene cyclase that catalyzes the cyclization of farnesyl diphosphate (FPP) to various sesquiterpenes, including alpha-copaene, beta-copaene, beta-elemene, alpha-muurolene, gamma-muurolene and delta-cadinene.
What are the official names of this protein?
Sesquiterpene synthase 1, Terpene cyclase 1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: Y038_ALKCK
Sequence: MEMKNMGNMMKQMQKMQKQMMKAQEELKEKTVEATVGGGMVTVIASGDKRILEVNISEDVVDPDDVEMLQDLIIAATNEALKKVDELVEQDLGKFTKGLNMPGMF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein ABC0038.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PARE2_MYCTU
Sequence: MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAIDILAVRHGMENPNAVEAEISGRTFE
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Upon expression in E. coli inhibits cell growth and colony formation.  Its toxic effect is neutralized by coexpression with cognate antitoxin ParD2.
What are the official names of this protein?
Toxin ParE2.
What is the protein family that this protein belongs to?
Belongs to the RelE toxin family.
Protein: DAPH_CLOB8
Sequence: MSYNLTDPYEIARFIKESKKSTPVKVYVNGDLSNAEMNDVEWYGSNGFYILMGESDSITKIVLDNKHLIKHFRIENDRRNSAIPMLDLLEVDARIEPGAIIRDKVTIGKNAVIMMGAVINIGAEIGDGTMVDMNAVVGARGQLGKNVHLGAGAVVAGVLEPPSKEPCMIGDNALIGANSVILEGVKIGAGSVVAAGSVVTEDVPDNVVVAGSPAKIIKAVDDKTKDKTQILDDLRK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: COX42_HUMAN
Sequence: MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVIWWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial, Cytochrome c oxidase subunit IV isoform 2, COX IV-2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase IV family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: LSRD_YERPA
Sequence: MNLYRRYGWELTLAALLVLEILLFGLSNSRMLDINVLLFSTSDFICIGIVALPLTMVIVSGGIDISFGSTIGLCAIFLGIVFQAGVPMSVAIPLTVLVGALCGLINAGLILYTGVNPLVITLGTLYLFGGSALLLSGLSGATGYEGIGGFPAAFTDFANQTLFGLPIPLVIFMLCVLLFWLLMHRTHSGRHVFLIGQSSRVARYSALPIARTLCMLYAMTGVASAISAILLVSYFGSARSDLGASFLMPAITAVVLGGANIYGGSGSILGTALAVLLVGYLQQGLQMIGTPNQISSALSGALLILVVVGRSISLHRHLIYEWLQRRRSRKASA
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Autoinducer 2 import system permease protein LsrD, AI-2 import system permease protein LsrD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TBB2_WHEAT
Sequence: MREILHIQGGQCGNQIGAKFWEVVCDEHGIDPTGRYTGTSDLQLERVNVYYNEASCGRFVPRAVLMDLEPGTMDSVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPTGLSMASTFVGNSTSIQEMFRRVSEQFTSMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATSDEEGEYEDEDQEPEEDM
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-2 chain, Beta-2-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: BBS5_DANRE
Sequence: MASVLDALWEDRDVRFDITAQQMKTRPGEALIDCLDSIEDTKGNNGDRGRLLVTNLRIIWHSLALPRVNLSVGYNCIINITTRTANSKLRGQTEALYILTKSNNTRFEFIFTNVVPGSPRLFTSVIAVHRAYETSKMYRDLKLRGALIQNKQLRLLPQEQVYDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNESFNVSIPYLQIRSIRIRDSKFGLALVIESSQQTGGYVLGFKIDPMDKLQDAVKEINSLHKVYSANPIFGVEYEMEEKPQPLEELTVEQPPDDVEIEPDEHTDAFTAYFADGNKQHDREPVFSEELGLAIEKLKDGFTLQGLWEVMG
What is the function of this protein?
Required for ciliogenesis.
What are the official names of this protein?
Bardet-Biedl syndrome 5 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the BBS5 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Protein: RPAB3_DICDI
Sequence: MTSILFEDTFEVKEIDPDGKKFDRVSRFVCYSENYEMDLQIDIATHIYPLGHERFKMVLASSLNLDGSSDNSGSYDTNKPSLADKYDYVMYGKIFKYQKENSSSKVSVFASFGGLLVLLQGDPRYLPGIELDARIYLLIKKA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit rpabc3, RNA polymerases I, II, and III subunit ABC3, RNA polymerase B subunit 8, RPB8, RPB17.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SYK_XANCP
Sequence: MTEQTPTPQLPADENSLIAERRAKLGALRGQGIAYPNDFVRTHFAGDLQAEFAEAETWTAEALEAADRSVKLAGRLMAKRVMGKASFAQIQDESGRVQLFLQGNVLGDAYTAFKGWDVGDIVAVEGGLTRTKTGELSVKATALRLLTKSLRPLPDKWHGLSDVEQRYRQRYVDLIVTPEAREVFIKRSKIIRAIRAWLDARRFLEVETPMMHYIPGGATAKPFTTHHNALDLDLYLRVAPELYLKRLVVGGLERVYEINRNFRNEGVSTRHNPEFTMLELYEAYATYHEIMDLTEQVIRDTAQGVLGTTQVSWDGADIDLAPAFRRWRMDEAVRHHNPEISAADCTDRAALLRHCERLKIKVKPSYGWGKLLLEIFESTVEHTLVQPTFITDHPVEVSPLARASDTEPGYTDRFELFINGKELANGFSELNDPEDQAARFQAQVQAKDGGDDEAMHYDADYIRALEYGMAPTGGLGIGIDRLVMLLTGSTSIRDVLLFPYMRPEA
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEK7_MOUSE
Sequence: MDEQSQGMQGPPVTQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVYDVAKRMHACTAST
What is the function of this protein?
Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:20473324).  Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:20473324).  Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity).  Phosphorylates RPS6KB1 (By similarity).  Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:26814970).  Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26553871, PubMed:26642356, PubMed:26814970).  Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:26814970).
What are the official names of this protein?
Serine/threonine-protein kinase Nek7, Never in mitosis A-related kinase 7, NimA-related protein kinase 7.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle (By similarity). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (By similarity). Interaction with ANKS3 prevents its translocation to the nucleus (PubMed:26188091).
Protein: TBXT_CHICK
Sequence: MGSPEDAGKAPAYRVDHLLSAVESELQAGSEKGDPTERELRVALEDGELWLRFKELTNEMIVTKNGRRMFPVLKVSVSGLDPNAMYSFLLDFVAADGHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHSFPETQFTAVTAYQNEEITALKIKYNPFAKAFLDAKERNDHKDMMEEAGDNQQSGYSQLGSWLIPGAGALCPPANPHSQFGAPLSLSPAHSCERYSPLRNHRSAPYPNPYTHRNNSPTAYTDNSSACLPMLQSHDNWSSLGVPTHTTMLPMSHSTGTATSSSQYPNLWSVSNSTITPAPQSSGMSNGLSSQFLRGSPVHYTALPHPVTATTSTSPLYDGGAPADLPDSQYDASAHTRLASMWTPITPPSM
What is the function of this protein?
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation.  Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
What are the official names of this protein?
T-box transcription factor T, Brachyury protein, Protein T.
What are the subcellular locations of this protein?
Nucleus.
Protein: NTRK3_MACFA
Sequence: MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIRNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNNQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
What is the function of this protein?
Receptor tyrosine kinase involved in nervous system and probably heart development.  Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
What are the official names of this protein?
NT-3 growth factor receptor, Neurotrophic tyrosine kinase receptor type 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PALLD_RAT
Sequence: PEEICTLVIAESFPEDAGIFTCSARNDYGSVTSTAQLVVTSANTENCSYDSMGEPNSDHFQHFPPPPPILETGSYELASQKPSEIQQVNTPNLGFNMAALQMQFNSAERETNGVHPSHGVNGLINGKAYGNKSPPTPAALLSPTKEPPPLLAKPKLGFPKKASRTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSANVFNIQEPEETAANQEYKVSSCEQRLISEIEYRLERSPVEESGDEVQEAEVPVENAAAPFFEMKLKHYKIFEGMPVTFTCRVAGSPKPKIYWFKDGKQISPKSDHYTIQRDVDGTCSLHTTASTLDDDGNYTIMAANTQGRVSCTGRLMVQAVNQRGRSPRSPPGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFIEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVY
What is the function of this protein?
Cytoskeletal protein required for organization of normal actin cytoskeleton.  Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types.  May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays.  Binds to proteins that bind to either monomeric or filamentous actin.  Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles.  Different isoforms may have functional differences.  Plays a role in neurite outgrowth and in the establishment of polarity during neuronal morphogenesis.  Participates in the acquisition of the reactive astrocyte morphology.
What are the official names of this protein?
Palladin.
What is the protein family that this protein belongs to?
Belongs to the myotilin/palladin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, ruffle. Cell projection, podosome. Cell projection, lamellipodium. Cell projection, axon. Cell projection, growth cone. Note=Localizes to stress fibers (PubMed:16868024, PubMed:11553711, PubMed:16125169, PubMed:22659164). Localizes to Z lines (PubMed:16868024, PubMed:11553711, PubMed:16125169). Preferentially expressed in the excitatory presynaptic terminals (PubMed:11438925).