PharMolix/UniProtQA huggingface dataset:
Protein: DAPA_CLOPE
Sequence: MFKGSCVALITPFTEDGVNYEELRKLLEWHIKNHTDAILVCGTTGEGSTMTLEEKKEVIKFSVEVVNKRVPVIAGTGTNNTKASIELSKYAEEVGADMVLIITPYYNKTSQKGLYAHFSAINDAINIPIMLYNVPSRTGMNITPLMLDKLADLNNVVAIKEASGDLSQVAKMAELCGDRIAIYSGNDDQIVPILSLGGAGVVSVLANILPEETHNICEKYFLGEVIESRNLQLKYLSLANSLFIETNPIPVKTAMNLMNFNCGPLRLPLCEMEDSNLIILEENLKANGLIK
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_LEGPH
Sequence: MSEEKKQWSISDIEAIYQQPFNDLLYQAHTIHRTYHDPNSLQFATLLSIKTGACPEDCGYCSQSGHYKTHVEKEKLMSVEEVLQCAKEAKEGGAKRFCMGAAWRCPPDKAIPQLKEMIEGVKSLGLETCMTLGMLTKEQASHLKEAGLDYYNHNIDTSPSYYDKVVTTRKFSDRLDTLNNVRSAGINVCCGGILGLGETREDRIEFLLTLANMETPPESVPINRLIPVEGTPLAQAERVEGIELVRTIATARILMPKSAIRLTAGRTEMSDELQALCYFAGANSVFIGDKLLTEDNPQRFKDKTLFNKLGLTEMV
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: ACY3B_DANRE
Sequence: MASVFLPALGGVAVCGGTHGNELSGVYLVQEMERQRKEKGDGVWPIPVTTVLSNPRAVKECRRYIDTDMNRCFSRDTLSTPITDSSPYEVRRAQELNNQLGPKESTGAIDMICDLHNTTSNMGLTLIHYTTSDWATLHICKYLQTKITKVPVRVMVLDVPYSDAYSLESVSKHGFSIEVGPQPHGVVRADIYVIMKEAVDLTIDWIHKFNSGTVFEGGDVEAFKIIKSVDYPRDPVTRSLNAAVHPQLQDRDFCLLKRGDPLFLSFSGETVKYEEEEPLHPLFINECAYYEKGIAFHLAKRMRLTIPAVQVQKD
What is the function of this protein?
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.
What are the official names of this protein?
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) B, Aminoacylase-3.2, ACY-3.2, Aspartoacylase-2B.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein. Cytoplasm.
Protein: RS17_CUPPJ
Sequence: MTEAAKTETSLRRTLVGRVVSDKMDKTVTVLVENRVKHPLYGKYVLRSKKYHAHDEANQYKEGDKVEIQEGRPLSRTKSWVVSRLVEAARVI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: CAIF_SHIFL
Sequence: MCEGYVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTEISCEVKMIPNKLEGRGCQCQRLVKVVDIDEQIYARLRNNSREKLVGVRKTPRIPAVPLTELNREQKWQMMLSKSMRR
What is the function of this protein?
Potential transcriptional activator of carnitine metabolism.
What are the official names of this protein?
Transcriptional activatory protein CaiF.
Protein: RPOA_NOSS1
Sequence: MAQFQIECVESNTEESRNHYSKFILEPLERGQGTTVGNALRRVLLSNLEGTAVTAVRIAGVSHEFATVPGVREDVLEIIMRMKEVILKSYSSQAQIGRLLVNGPTTITASHFDLPSEVEVIDPTQYVATIAEGGKLEMEFRIERGKGYRTVERGREEATSLDFLQIDSIFMPVRKVNYSVEEVRADGSIPKDRLLLEVWTNGSISPQEALSSAAGILVDLFNPLKDISLEPTDTNSDIPDDPTAQIPIEELQLSVRAYNCLKRAQVNSVADLLDYTQEDLLEIKNFGQKSAEEVVEALQRRLGITLPQERSSKHN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RUVC_ECO7I
Sequence: MAIILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: HUTU_MYCS2
Sequence: MEGARPVRAPRGTTLTARSWATEAPLRMLMNNLDPENAERPDDLVVYGGTGRAARNWASFDAMVRTLTTLREDETMLVQSGKPVGVFQTHEWAPRVLIANSNLVGDWATWPEFRRLEAMGLTMYGQMTAGSWIYIGTQGIVQGTYETFAAAAEKRFGGTLAGTLTLTGGCGGMGGAQPLAVTLNGGACLIVDVDEARLRRRVEHRYLDEVADNLDDAVTKAVATRKDKRAWSVGVVGNAAEVFPELLRRGVPIDLVTDQTSAHDPLSYLPIGISVEDWEDYATKKPDEFTERAEESMAVQVRAMVEFQDAGAEVFDYGNSIRDEARKAGYDRAFEFPGFVPAYIRPQFCEGRGPFRWVALSGDPKDIHATDEAIMKLFPDDDRLQKWMRGAREKISFQGLPARICWLGYGERDKAGVLFNDLVASGKVSAPIVIGRDHLDSGSVASPYRETEAMLDGSDAIADWPLLNALTATSSGATWVSIHHGGGVGIGRSIHAGQVGVADGTELAAQKLSRLLTNDPGMGVIRHVDAGYERAEEIAAERGVRIPMREGE
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_RHOBA
Sequence: MVVGQRERKRRCIRGEPLMNDTTWVLDGGRLIDPANGIDRIARLVLHEGKVHSIDTPDGDVPPDAGRLDVTGKIVAPGLVDLATELREPGSEEDETIQTGSNAALAGGYTTVLCCSSTKPLMDSAASVQLVRQIAQRVDGVRVLPIACLSKGRQAEQMAELGILAAAGAAGFSDTPRPMPNDALLKRALDYCRMFDLPIFDRPEVPELADGGVMHDGQIGLILGLKGLPTEAEDLAVARDVRLAEATKGRLHVGPVSTMGSIDMIGRVKSRGIHISASVCPHNLFGSDELLRSYDSRYKVHPPMRSPSHVEALRNAVAEGVIDAIESGHMPRAQEKKANDLDLAPFGASALETTLAAIATDLVETKILPWSRAIECLSTAPARIAGVKGGTLSVGANADVTVIDPLNAWSVEAKEFRSRCHSSPMTGRTLTARVTHTLVGGRLKFELHPTVASAAS
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Putative dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: HTR1_MAGO7
Sequence: MQLSNFLSIWALVAMGATAAPMPSGSAPGNPFADGEAYGARPSQGLTPVPKVHDGSYHSCETCAAPFRTEERLAAHRQADHGNQGAAARGSGRHTSKNRGSSKTSERERLDRLASRVGEDYVEKRSQEATEEQEQGHVKPGRSKKEIAQRIRNLPVTPWNQYGAAVKLDKPTRKEQYRQLPGNDRLTPFEEQGDPVQL
What is the function of this protein?
Secreted effector that translocates into the nuclei of host cells to reprogram the expression of immunity-associated genes by binding to effector binding elements (EBEs) in rice (PubMed:33203871).  Binds the 5'-CAATCTTC-3' EBE of promoters from targeted rice genes and probably recruits a yet to be determined host repressor (PubMed:33203871).  Causes ambivalent immunity with increased susceptibility to the hemibiotrophic pathogens Magnaporthe oryzae and Xanthomonas oryzae pv.  oryzae, but enhances resistance to Cochliobolus miyabeanus, a necrotrophic pathogen (PubMed:33203871).
What are the official names of this protein?
Host transcription reprogramming factor 1, Secreted nuclear effector HTR1.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Note=Secreted via the biotrophic interfacial complex (BIC) and translocated into the nuclei of initially penetrated and surrounding cells.
Protein: COBT_SALEP
Sequence: MQTLHALLRDIPAPDAEAMARAQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGEKAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGGFDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIALAHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLPEGNANAT
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RS6_HYPNA
Sequence: MALYEHVVITRPDISPAQVESFIEEMTTFLKEKGATVGKTEYWGLRSLAYPIKKQRKGHYSLINIDGPADAIHELERRQRIAEDVMRYMTVRVETLSDEPSPVLSRKERRRD
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: TM86B_HUMAN
Sequence: MDAGKAGQTLKTHCSAQRPDVCRWLSPFILSCCVYFCLWIPEDQLSWFAALVKCLPVLCLAGFLWVMSPSGGYTQLLQGALVCSAVGDACLIWPAAFVPGMAAFATAHLLYVWAFGFSPLQPGLLLLIILAPGPYLSLVLQHLEPDMVLPVAAYGLILMAMLWRGLAQGGSAGWGALLFTLSDGVLAWDTFAQPLPHAHLVIMTTYYAAQLLITLSALRSPVPKTD
What is the function of this protein?
Enzyme catalyzing the degradation of lysoplasmalogen.  Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens.  May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.
What are the official names of this protein?
Lysoplasmalogenase, Transmembrane protein 86B.
What is the protein family that this protein belongs to?
Belongs to the TMEM86 family.
Protein: HIG2A_HUMAN
Sequence: MATPGPVIPEVPFEPSKPPVIEGLSPTVYRNPESFKEKFVRKTRENPVVPIGCLATAAALTYGLYSFHRGNSQRSQLMMRTRIAAQGFTVAAILLGLAVTAMKSRP
What is the function of this protein?
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water.  May be involved in cytochrome c oxidase activity.  May play a role in the assembly of respiratory supercomplexes.
What are the official names of this protein?
HIG1 domain family member 2A, mitochondrial, RCF1 homolog B, RCF1b.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane.
Protein: IF12_AROAE
Sequence: MAKEELLEMEGVVNEVLPDTRFRVTLENGVEVQAYASGKMRKHRIRILAGDKVSVELSPYDLTKARISFRHKDERPAGAPSQFRRR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 2.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHST8_HUMAN
Sequence: MTLRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPGIKFNIRPRQPHHDLPPGGSQDGDLKEPTERVTRDLSSGAPRGRNLPAPDQPQPPLQRGTRLRLRQRRRRLLIKKMPAAATIPANSSDAPFIRPGPGTLDGRWVSLHRSQQERKRVMQEACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFDRQGILHRLSTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLSLIRAPRNLTFPRFKDRHSQEARTTARIAHQYFAQLSALQRQRTYDFYYMDYLMFNYSKPFADLY
What is the function of this protein?
Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans.  Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures.  Only active against terminal GalNAcbeta1,GalNAcbeta.  Not active toward chondroitin.
What are the official names of this protein?
Carbohydrate sulfotransferase 8, GalNAc-4-O-sulfotransferase 1, GalNAc-4-ST1, GalNAc4ST-1, N-acetylgalactosamine-4-O-sulfotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: DAPB_TRIV2
Sequence: MTNQAPIPVIVNGAAGKMGREVVKAIAQAPDLNLLGAIDSSPEHQGKDAGELAGLSEPLEVPITNQLEPMLGYVAGERQGPPGVIVDFTHPDSVYDNVRSAIAYGIRPVVGTTGLSPAQIQNLADFAEKASTGCLIIPNFSIGMVLLQQAAVTASQYFDHVEIIELHHNQKADAPSGTAIQTAELLAELGKTFNSAIVEETEKIPGARGSLAGEGIRIHSVRLPGLIAHQEVIFGAPGQIYTLRHDTSDRACYMPGVLLAIRKVLQLKSLVYGLEKIL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYVC_RAT
Sequence: MSILYVSPHPDAFPSLRALIAARYGEAGDGPGWGGPHPRICLQPPPSSRTPFPPPRLPALEQGPGGLWVWGAPAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELTPAACGATLPALGLRGPGQDPQAALGALGKALNPLEEWLRLHTYLAGDAPTLADLAAVTALLLPFRYVLDPSARRIWGNVTRWFNTCVRQPEFRAVLGEVVLYSGARSVTQQPGSEITAPQKTAAQLKKEAKKREKLEKFQQKQKTQQQQPAHGEKKPKPEKKEKRDPGVITYDLPTPPGEKKDVSGTMPDSYSPQYVEAAWYPWWERQGFFKPEYGRPSVSAPNPRGVFMMCIPPPNVTGSLHLGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLQEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKSVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRLEAISIMDSKGALVNVPPPFLGLPRFEARKAVLAALKEQGLFRGIKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITVHDPAVPPGEDPDGRYWVSGRTEAEAREKAAREFGVSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTEKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGVSLQGLHDQLLNSNLDPSEVEKAKEGQRADFPAGIPECGTDALRFGLCAYTSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSPTSKPEGHESLVDRWIRSRLAEAVRLSNEGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAADCARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTPNAPASLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADYNLTRTRPDCFLEVADEATGALASAVSAYVQTLASAGVVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASGYSAKVPLEVQEADEVKLQQTEAELRKVDEAIALFQKML
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein: AK_HELPJ
Sequence: MLIVQKYGGTSMGSIERIHNVAQRVLESVKLGHQVVVVVSAMSGETDRLLEFGKNFSHNPNKREMDRIVSAGEWISSAALSMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTQRITELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALAGALKAHLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIVAEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIGRDGKTDLDFTIVKTQIEETKQALKPFLAQMDSIDYDENIAKVSIVGVGMKSHSGVASIAFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAVYQLDQ
What are the official names of this protein?
Aspartokinase, Aspartate kinase.
What is the protein family that this protein belongs to?
Belongs to the aspartokinase family.
Protein: RR11_ILLOL
Sequence: MTKPIPRIGLRRNGRIGLRKNGRRISKGVIHVQASFNNTIVTVTDVRGRVVSWSSAGTCGFRGARRGTPFAAQTAAGNAIRTVVDQGMQRAEVMIKGPGLGRDAALRAIRRSGILLSFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DEGQ_BACSU
Sequence: MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMKIS
What is the function of this protein?
Stimulates the phosphotransfer from phospho-DegS to DegU.  Affects protease and levansucrose production.
What are the official names of this protein?
Degradation enzyme regulation protein DegQ, Regulatory factor SacQ.
What is the protein family that this protein belongs to?
Belongs to the DegQ family.
Protein: 2BDD_HETMG
Sequence: SAALAGTIIAGASLGFQILDKVLGELGKVSRKIAIGVDNESGGSTTALNAYFRSGTGDVILPEFVPNQKALLYSGRKDTGPVATGAVAAFAYYMSNGHTLGVMFSVPFDYNFYSNWWDVKVYSGKRRADQGMYEDMYYGNPYRGDNGWHQKNLGYGLRMKGIMTSAGEAILQIKISR
What is the function of this protein?
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cytolysis.  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers (By similarity) This toxin shows hemolytic activity (PubMed:10665806).
What are the official names of this protein?
DELTA-stichotoxin-Hmg2b, DELTA-SHTX-Hmg2b, Cytolysin HmT, Hemolytic protein.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
Protein: PNP_PARP8
Sequence: MSLFNKVVKEFKWGQHTVRMETGEIARQASGAVLVDVEDTVVLATVVGAKTAKPGQDFFPLTVDYIEKTYSAGKIPGGFFRREGRPSEGETLISRLIDRPLRPLFPEGFYNEVQVVIHVMSINPEVPADIPALIGASAALAVSGLPFNGPVGAARVAYINNEYVLNPTRSQIKGSRLDLVVAGTERAVLMVESEADQLPEDVMLGAVVFGHEQMQTAIDAIHELVREGGKAEWEWQAAPKNEALISRVNEIAYNELLSAYQTRDKQARSTKLKEVYAATQAKLEEEAAAAGTVAADKASVGNVLFDIEAKIVRSQILNGEPRIDGRDTRTVRPIEIRTGVLPRTHGSALFTRGETQALVVATLGTKGDEQIIDALEGEYRDRFMLHYNMPPFATGETGRVGSPKRREIGHGRLAKRALAACLPSAEEFGYSIRVVSEITESNGSSSMASVCGGCLALMDAGVPMKAHVAGIAMGLILEGNKFAVLTDILGDEDHLGDMDFKVAGTADGVTALQMDIKIQGITKEIMQVALAQAKEGRMHILGKMTSAVSGVNTELSAYAPRMITIKINPEKIRDVIGKGGSVIRALTEETGTTIDISDDGVVTIASTSSEGMAEAKKRIENITAEVEVGQVYEGTVLKLLDFGAIVNLLPGKDGLLHISEIANERIKDINDYLKEGQQVKVKVIQTDEKGRVRLSAKALLNEAAQTEPTPQQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PT432_ARATH
Sequence: MGKGGALSDGVIKKILLSYTYVAIWIFLSFTVIVYNKYILDKKMYNWPFPITLTMIHMAFCSSLAVILIKVFKIVEPVSMSRDTYIRSVVPIGALYSLSLWLSNSAYIYLSVSFIQMLKALMPVAVYSIGVLLKKESFKSETMTNMLSISFGVAIAAYGEAKFDTWGVMLQLGAVAFEATRLVLIQILLTSKGINLNPITSLYYVAPCCLVFLFFPWIFVELPILRETSSFHFDFVIFGTNSVCAFALNLAVFLLVGKTSALTMNVAGVVKDWLLIAFSWSVIKDTVTPLNLFGYGLAFLGVAYYNHCKLQALKAKDAQKKVQQGDEEEAGKLLEERESEAAAKRNETED
What are the official names of this protein?
Probable sugar phosphate/phosphate translocator At4g32390.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. TPT (TC 2.A.7.9) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PCNA_METM5
Sequence: MFRATCNTRDFKKVINATSNLVDEICFEVDENGIKASAMDPSHVALVSMEMPKDVFEEYEGDVHDIGIDLEALKKIIARGKGDEKLILDLDAEKNKLNVTFKSNVTRKFSIALYDVSSSNLKVPDIEYPNNVSIKAGAFVEALKDAELVNDHITLKVDEDKFIIYSKGDLNQSETVFDNGVDDDDDTLAEFNMGEASRSTFNLAYLKDLTKSTAAEDLLKIYLGSDMPVKIEYEVSGSKLVFLLAPRIES
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp, Proliferating cell nuclear antigen homolog, PCNA.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: U512U_DICDI
Sequence: MAIFKSISSISNPTGSMGSSIGTSNIDGLTNNNNSIACFDSDYSGLNGLGGLGGFNGGGCGGCGDSNTNIINIDIDLCRRGHRCC
What are the official names of this protein?
UPF0512 protein U.
What is the protein family that this protein belongs to?
Belongs to the UPF0512 family.
Protein: FPG_SPHAL
Sequence: MPELPEVETTVRGLVPFLEGQRLAAVTTFRPDLRRPFPVDLAQRLTGATVTRLSRRAKYGIVSTDRDDHMIFHLGMSGRWRTEGGEPGKHDHLLLETGAGHRLFLHDPRRFGSIDLVAGDPLASFAAFVTLGPEPLSDDFDAALLARAFAARRAPVKAMLLDQNVVAGLGNIYVCEALNMARISPLMPAAGVPKAKLAALVSAIRAVLTAAIAAGGSTLRDFLSPDGDLGYFAKDWRVYGREGEACECGGAIVRVVQSGRSTFYCRKCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.