PharMolix/UniProtQA huggingface dataset:
Protein: LKA2A_MANHA
Sequence: MGTRLTTLSNGLKNTLTATKSGLHKAGQSLTQAGSSLKTGAKKIILYIPQNYQYDTEQGNGLQDLVKAAEELGIEVQREERNDIATAQTSLGTIQTAIGLTERGIVLSAPQIDKLLQKTKAGQALGSAESIVQNANKAKTVLSGIQSILGSVLAGMDLDEALQNNSNQHALAKAGLELTNSLIENIANSVKTLDEFGEQISQFGSKLQNIKGLGTLGDKLKNIGGLDKAGLGLDVISGLLSGATAALVLADKNASTAKKVGAGFELANQVVGNITKAVSSYILAQRVAAGLSSTGPVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKNNQGKNYFENGYDARYLANLQDNMKFLLNLNKELQAERVIAITQQQWDSNIGDLAGISRLGEKVISGKAYVDAFEEGKHIKADKLVQLDSAKGIIDVSNTGEAKTQHILFRTPLLTPGTEKRERVQTGKYEYITKLNINRVDSWQIKDGAASSTFDLTNVVQRIGIELDHAENVTKTKETKIVAKLGAGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETVQGSYTVNRFVETGKALHEVTSTHTALVGSREEKIEYRHSNNRQHAGYYTKDTLTTIEEIIGTSHNDIFRGSKFNDAFQGGDGVDTIDGNDGNDRLFGGKGDDIIDGGNGDDFIDGGKGNDLLHGGRGDDIFVHRKGDGNDIISDSDGNDKLSFSDSNLKDLTFEKVKYNLVITNSNKEKVTIQNWFREADLAKEVHNYKATADEKIEEIIGQNGERITSKQVDDLIEKGNGKITQDELSKAVDNYELLKHSKNVTNSLDKLISSVSSFTSSNDSRNVLVAPASMLDQSLSSLQFARAA
What is the function of this protein?
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture.  The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity).  This leukotoxin is a major contributor to the pathogenesis of lung injury in bovine pneumonic pasteurellosis.  It has also weak hemolytic activity.
What are the official names of this protein?
Leukotoxin, Lkt.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: NHAA1_HELHP
Sequence: MSEAKITPSRHSYVKDRLQDSLNRFIKHESFGGVLLAFCVGAAMLVANSSYADMYFTFFHSEFGAFFSDSHFKVSLQDFINDVLMSFFFLLVGLEMKREMLYGELAGFKKVSFSFLAAFGGIICPVMIYSYFNSGTAYESGFGVAMSTDTAFALGLIMLLGDRVPKILKIFLVTLAVADDLGAISVIAIFYSDNINMQWIYASLILVAVLIYLNYRDTKYLSLYFLAGILLWFCVHHSGIHVTIAAVILAMAIPGRTRVNKKYFINMLKEFERMKVATNDWNDVVYARESEKVGFWRGSFKNIRSFIFGNQDVEKKIDMAKTSQLVHMLDTIGTYSRYAQNPLIRLEIALQPICAYFFVPLFAFANAGVTLEGNIDISLNSVMLGTILGLVVGKPVGVLLFCFLGEKLNLATRPKDLNYLHILSVGMISGIGFTMSMFVANLAYKDDIMSIDMSKISILVASSIAAVLGLLVVYLSTIKQDNQLENINEEDEIQKLKETQSII
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RHAT_ECO55
Sequence: MSNAITMGIFWHLIGAASAACFYAPFKKVKKWSWETMWSVGGIVSWIILPWAISALLLPNFWAYYSSFSLSTLLPVFLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIVGTLMTPIINGNFDVLINTEGGRMTLLGVLVALIGVGIVTRAGQLKERKMGIKAEEFNLKKGLVLAVMCGIFSAGMSFAMNAAKPMHEAAAALGVDPLYVALPSYVIIMGGGAIINLGFCFIRLAKVKDLSLKADFSLAKPLITHNVLLSALGGLMWYLQFFFYAWGHARIPAQYDYISWMLHMSFYVLCGGIVGLVLKEWNNAGRRPVTVLSLGCVVIIVAANIVGIGMAN
What is the function of this protein?
Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).
What are the official names of this protein?
L-rhamnose-proton symporter, L-rhamnose-H(+) transport protein.
What is the protein family that this protein belongs to?
Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FLGI_SALPA
Sequence: MFKALAGIVLALVATLAHAERIRDLTSVQGVRENSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASYPPFARQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAIIERELPTQFGAGNTINLQLNDEDFTMAQQITDAINRARGYGSATALDARTVQVRVPSGNSSQVRFLADIQNMEVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQLNVNQPNTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSANLNSVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: MURB_STRPZ
Sequence: MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNRYELSRIVAYANKENMPWLVLGNASNLIVRDGGIRGFVIMFDKLNAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISARDMAFGYRHSAIQETGDIVISAKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHRIGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CI057_HUMAN
Sequence: MKKIEISGTCLSFHLLFGLEIRMRRIVFAGVILFRLLGVILFRLLGVILFGRLGDLGTCQTKPGQYWKEEVHIQDVGGLICRACNLSLPFHGCLLDLGTCQAEPGQYCKEEVHIQGGIQWYSVKGCTKNTSECFKSTLVKRILQLHELVTTHCCNHSLCNF
What are the official names of this protein?
Uncharacterized protein C9orf57.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL7A_ARCFU
Sequence: MYVRFEVPEDMQNEALSLLEKVRESGKVKKGTNETTKAVERGLAKLVYIAEDVDPPEIVAHLPLLCEEKNVPYIYVKSKNDLGRAVGIEVPCASAAIINEGELRKELGSLVEKIKGLQK
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_SYNP6
Sequence: MSRVCQLTGKKANNAYAISHSHRRTKRLQNVNLQEKRIWWPEGNRFVKLRLSTKAIKTLQKKGLSAYARELGIDLKRL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: NTE1_CRYNB
Sequence: MSSIPTPPDANGNPLIALAVAVIYAILYVLQGVKYGVSLLTIGIPSCIVRMLQYSLTISLGFPHLLALFAGALLALFFLIRYRYLTRYAQLKESALPPPSPPALASRLLPLDGDGLGLPDSRSQTSSFHNYLDDFLSAIRIFGYLEKPVFHELSRHLQTRRLAAGDTLEIGGGEFWCVVEGKVQVFAPDASSQGTPTPSSDTNSPTRPSFNGYHLLNEVSTGGTLSSLFSILSLFTEDIKLSWKSSADDEGEEEQIFEGAPEQSSAKLRVRRANSDVSQLGPDSIGVRAMDPTPLPESIDSHGDSSVPQRRRERSSSIDAAGETVREREGIFASASLPISSTEPPSPRRSQSLRSSPRLNSATNLLSSQSEHLRSSVPRKAGIEIGSKALKGTIARATEDTTLAVIPAAAFRKLTRKFPKASGTIVQVVLERFSRVTFMTAHKYLGLTREILQTESSLNLLVTHPLPRSFYTGGGMQALRARFQPEALAKESVHYDSLKSSPNARVSSKDYFNYVPASPTVKAPSLPAMTPKPLSPIIHKSSLGQTATTTVKNEPLNGGSSPLDETRDKVPSFGLSTAAATNPDASFRHASPFIRRTSAMRQQVAAGDLAMSVHNLPDESGQAYYRPTAITPGLSKMDTWQRRYSSSWNLNDSPHTDGQPVDPQRDDESLLNESFDLKEAVLNSIAKSIGLYQEAESNSDMIARSSMAPSVSALSTPNSPMFPPNAGTPLQGSTRSRPPHFGNVLDLINASSQNEGVIGGMLREAAFNSRPDDEASSISMSLHDSQGGASGVDRKIMKDLERHVEILFFKKGSVLVKEGERSPGMYYVIDGFLETSLPFRSTSSNQENPNSTPGSKHRQSSFGSSNERPFKTALGLDTSKGKELDDGSKKDEALFTVKPGGIAGYLSSLCCTDSYVDITAKTDCFVGFLPHHTLERIIERRPIVLLTLAKRLLSLLSPLVLHIDAALDWQQLNAGQVLYEKGDKSTDFYIVINGRLRAFTEKNDNMHVLREYGQNDSIGELDVITAVDRSETVHAIRDSELVRIPAALFDAISIKHPETTVQFMRLIAGRVRRALGDEMNGRVPGLPTTDMNLKTVCVLGSTRNVPVTQFAGKLKNALEEIGASTSYLDQGIVMRHLGRHAFARIGKLKVAGWLADQEQHYRTVLYVADSPPASQWTLTCIRQADLVLVVSMGDDPSLGEYEKLLLATKTTARKELILLHDERTVAPGSTRQWLSNRPWIQTHYHVELPGVVTPARPIPPVHDAAAIAAFKHLREQVETRIKKYRGLRPFTRPRRPPHMNDFARIARRLCGQQIGLVLGGGGARGISHIGMLQALEEFGIPIDAIGGCSIGSFVGGLYARETDLLETAGRTKQFSGRMGSMWRILSDVTYPFVSYTTGHEFNRGIYKAFYNTHIEDFWIPFFANSTNITHSRMEVHRTGYAWRYVRASMTLAGLLPPLSDNGNLLVDGGYMDNTPIQPLRENGIRDIIVVDVGSVDDTSPRDYGDSVSGWWIFFNRFNPFYERRVLSMTEISSRLTYVSSVKTLEGVKATPGCHYIAMPVQQFDTLGGFKRFSEVMEIGLKAGRETLKKWKEEGKLPTGLVDEAKGSKAVQRGNRLRRMSI
What is the function of this protein?
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho).  Plays an important role in membrane lipid homeostasis.  Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
What are the official names of this protein?
Lysophospholipase NTE1, Intracellular phospholipase B, Neuropathy target esterase homolog.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MTND_PSEU2
Sequence: MSSLSVYHVSSPDMPNKVLTHLEDIASTLAEHGVAFDRWEAATPITPGASQEEVISAYRTQIDTLMTERGYVTVDVISLNSDHPQKAELRARFLEEHRHGEDEVRFFVAGRGLFTLHIDDYVYAVLCEKNDLISVPAGTRHWFDMGENPHFVAIRLFNNPEGWVANFTGEDIAGRFPRLED
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: CAS2_TREDE
Sequence: MRVIVFFDLPVITPENRHNYSVFRKYLIKSGFIMQQKSVYSKLVLNLTNRDSIVKSIEKNKPPEGLVEVLTVTEKQYAKMEIIIGESKTEYLNTDERLVVL
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette.
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: NUOD_XANC5
Sequence: MSEFRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPYMDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEAVSGARMHAAYYRPGGVYRDLPDRMPQYKESRWHKGGALKKRNAGREGTMLDFLEEFTNTFPARVDEYETLLTDNRIWKQRTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDIPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKWLKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYSAVEAPKGEFGCYLMSDGANKPFRVHLRAPGFAHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DXS_MYCBP
Sequence: MLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYPSRAESEHDWVESSHASAALSYADGLAKAFELTGHRNRHVVAVVGDGALTGGMCWEALNNIAASRRPVIIVVNDNGRSYAPTIGGVADHLATLRLQPAYEQALETGRDLVRAVPLVGGLWFRFLHSVKAGIKDSLSPQLLFTDLGLKYVGPVDGHDERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEADQAEQMHSTVPIDPATGQATKVAGPGWTATFSDALIGYAQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFDVGIAEQHAMTSAAGLAMGGLHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVLDRAGITGSDGASHNGMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVGEDISALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGIGVTVIDPRWVLPVSDGVRELAVQHKLLVTLEDNGVNGGAGSAVSAALRRAEIDVPCRDVGLPQEFYEHASRSEVLADLGLTDQDVARRITGWVAALGTGVCASDAIPEHLD
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: A30_FOWPN
Sequence: MDDIDYIDDINEDSINHMLSTLANVRDPEFSATISLMQEVLKIINSRIIEIDKKYKKNNRNINSMNNASSRVSY
What is the function of this protein?
Required for the association between the dense viroplasm and the viral membranes to form the mature virion (MV).
What are the official names of this protein?
Protein A30 homolog.
What is the protein family that this protein belongs to?
Belongs to the chordopoxvirinae A30 family.
Protein: RPOC_TREDE
Sequence: MRDIQDFDSLMIRLASPDTIRAWSYGEVKKPETINYRTLRPERDGLFCERIFGTTKEWECFCGKFKSIRYKGVICDRCGVEVTHFKVRRERMGHIELAAPVSHIWYYRSVPSRMGLLLNLQVAALRSVLYYEKYIVIDANDTDLEPMQLLTEDEYRDAHERYGAAFTAGMGAGAIKTLLQNINLDELAAQLRAKMIEKGAKSDQRLLRRIEIVENFRASGNKPEWMILDVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVIHRNSRLSKLMELKAPDIIIRNEKRMLQEAVDALFDNSKRKKAIKGASNRPLKSISDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLWQCGLPTKMALELFKPFIMKKLVQKEVVSNIKKAKLLVEQEAAEVFAVLDEVVSEHPVLLNRAPTLHRLGIQAFEPVLVEGKAIRLHPLVCKAFNADFDGDQMAIHVPLTQAAQMECWTLMLSARNLLDPANGKTIVFPTQDMVLGLYYLTKERALPEGKKERLYSSVPEVLMAAECHAVGWQEPVLIDYETEPGKIETVRTTPGRILFNEEMPEGVPFTNYALNDKKIRKLIENVFKDKGPWLAVQLLDKLKAVGYKYATYFGATLSMEDMIIPPEKAGMLEKANKEVLEIYNQYKGGHITQEERYNRVVDVWQKTNSNLKEILMKRLQEDKGGFNTIHMMETSGARGSKDQINQLAGMRGLMSKPTGDIIELPIRSNFKEGLNVMEFFISTNGARKGLTDTALKTSDAGYLTRRLVDIAQNVVVNEEDCGTINGIEYAAIKRGDEIRESLSERIAGKYTLERVIHPITGELLIDVNEYITDETAKKIEEAGVETVKLRTVLTCESKHGVCVKCYGRDLARNRIVRIGEAVGIIAAQSIGQPGTQLTMRTFHEGGTASKNVEENRIVFNDYSIIVRGIKGSYVTLKNGHFLFTRKGEFTFSRVLNEYALKKGETALVSTGTRVVKGNPLYTLKNGKEVLSENIAIAEVRDNIIYLTGQEQTIEIRNGSEVVVKENDVIKAGETVGTFDPFADPILAEYDGFVRFEDILPGTTLKEEADEETGVVEKRISDAHFDKMQPRIFISDESGNTVGEDSYFLPGGAQLLVEEGQEIKAGAILAKIAKESVKTKDITGGLPRVSELLEARRPKSPAVLAAIAGVVTIKKGLLKGKRTIMVRDEYGHDVKHLVPIGKRMLVRDGDTVKAGEPLCDGSFDPHDILNILGENALQNYLMKEIKEVYDAQGVTINDKHVGIIVRQMLRKVKIVSVGDTKFIFDQQIDKYRFHEENKRVKEEGGQPAVARPMFQGITKAALNIDSFISAASFQETTKVLTNAAIAGSSDELRGLKENVIIGHLIPAGTGMKQYRDIKLFDKNKSDLDIQMNEILERRRLEAEAAQALEEKELIEEENFLDDL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: YVBG_VACCC
Sequence: MRRCIHIKERKIHMTNIVDRNVTFILTVVHKYVRYVPHTVANDAHNLVHLAHLIHFIIYFFIIRDVRKKKKKKKKNRTIYFFSNVYARHIK
What are the official names of this protein?
Uncharacterized 11.2 kDa protein.
Protein: HERP1_HUMAN
Sequence: MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN
What is the function of this protein?
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405).  Could enhance presenilin-mediated amyloid-beta protein 40 generation.  Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).
What are the official names of this protein?
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, Methyl methanesulfonate (MMF)-inducible fragment protein 1.
Protein: RL11_YERPY
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTESIEKGLPIPVVITVYSDRSFTFVTKTPPAAVLLKKAAGIKSGSGVPNKDKVGKVTSAQVREIAETKAADMTGSDVDAMMRSIEGTAHSMGLVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: YGFZ_ALISL
Sequence: MMSTLFPKLSIKKEDTLPALAISELNDWALITMIGNDKKSYLQGQVTADVVTLPQDDITFGGHCDAKGKLWSIFQLFNHNDGYALFQRRSAIETELTEIKKYSVFSKVDIAVGDDVLLGISGKKATDWVNKHTTTDANVRACELGTFAKISETQWLLVTTPEHKKNIINQESNTVLCDESLWSLHTIQHGLPQLDNALSNAHIPQAMNLQAVGGISFAKGCYTGQETVARAKYRGINKRAMYLLSGQSNSIPVAGDAIERSVGENWRKGGTIVSAYRFEDGYTLALAILPNDLEEGTQFKLQDSIWNKGNQPYSLDEE
What is the function of this protein?
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs.  It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
What are the official names of this protein?
tRNA-modifying protein YgfZ.
What is the protein family that this protein belongs to?
Belongs to the tRNA-modifying YgfZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_PELPD
Sequence: MIALLTGQIAQKSPDHIILDVNGVGYRVQIPFSTYYDLPEEGTVSLHIHTSVREDAIQLYGFRTSLEKSFFQLLLSVSGVGPRLARDILSNIQPAQLAQALGQGDIRMLSAVPGIGKKTAERLVLELKEKVGKLDLSSVVVPEPRQMPEDDLLEDVVSALLNLGYKEPQVRKVLAGLNPGSDASLEGVLKQALKSLMR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: NU6C_CYCTA
Sequence: MDLPGPIRDILLVPLELGLILGGLEVVLLTNIIYSALSLGPVLVCISLLYILLNADFVAAAQILIYVGAVNVLIVFAVMLMNNQKYPNFVPLWTVGDGITLVVCTSLFCSLITIILNTSWSEISMTTKSNQILEQDLTNNVQRIGAHLSTDFFLPFELLSIILLVALVGAITIARREEIV
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: THOC3_ARATH
Sequence: MEETTIPFKSLHSREYQGHKKKVHSVAWNSNGTKLASGSVDQTARIWNIEPHGHSKAKDLELKGHTDSVDQLCWDPKHSDLVATASGDKSVRLWDARSGKCTQQVELSGENINITYKPDGTHVAVGNRDDELTILDVRKFKPLHRRKFNYEVNEIAWNMPGDFFFLTTGLGTVEVLSYPSLKPLDTLTAHTAGCYCIAIDPKGRYFAVGSADSLVSLWDISDMLCLRTFTKLEWPVRTISFNYSGEYIASASEDLFIDIANVQTGRTVHQIPCRAAMNSVEWNPKYNLLAYAGDDKNPKYNTDEGVFRIFGFESS
What is the function of this protein?
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export.  Contributes to the integrity of the endogenous trans-acting small interfering RNA (ta-siRNA) pathway.  May process or transport a long RNA molecule so that it can be a template for secondary siRNA production.  May participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center.  Required for the generation of functional messenger ribonucleoproteins (mRNPs).
What are the official names of this protein?
THO complex subunit 3, TEX1 homolog, AtTEX1.
What are the subcellular locations of this protein?
Nucleus.
Protein: KR203_HUMAN
Sequence: MSYYGNYYGGLGYGYDCKYSYTSGFGAFRILDCGYRCGCGGVWI
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 20-3.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 20 family.
Protein: GRAS_STAAT
Sequence: MNNLKWVAYFLKSRMNWIFWILFLNFLMLGISLIDYDFPIDSLFYIVSLNLSLTMIFLLLTYFKEVKLYKHFDKDKEIEEIKHKDLAETPFQRHTVDYLYRQISAHKEKVVEQQLQLNMHEQTITEFVHDIKTPVTAMKLLIDQEKNQERKQALLYEWSRINSMLDTQLYITRLESQRKDMYFDYVSLKRMVIDEIQLTRHISQVKGIGFDVDFKVDDYVYTDIKWCRMIIRQILSNALKYSENFNIEIGTELNDQHVSLYIKDYGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYLVNSVKDQLGIHLQVTSTVGKGTTVRLIFPLQNEIVERMSEVTNLSF
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).  Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX.  In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis.  Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis.
What are the official names of this protein?
Sensor protein kinase GraS, Glycopeptide resistance-associated protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MRAY_PELPB
Sequence: MIYYLLRYINDLFDLPGLHVIEYLTFRASAAAITALLITLFVGPGFIKYLKTRFIEPVKEEAPPEHKKKNKLPTMGGLLIIFSIEISVLLWSKFIDPHVWLIMLAILWMGIIGFIDDYRKVVLKIKGGLSARYKLIGQVTLGLVVGCYTWYDPSFSVLLSTTTVPFFKYLTIDYGYFYIPIVIFIITAVSNAVNLTDGLDGLAAGSSAIVVMGLGGFSYLAGNAVYAVYLNIPFIPGGGEIAVVSMAIVMACVGFLWFNSNPAEIIMGDTGSLALGSAIAVIALLIKQELLLPLIAGIFFLETLSVSLQVLYFKYTKMRYGQGKRIFLMAPLHHHFQLKGWAEQKIVIRFWILTILFFLASLMTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.