PharMolix/UniProtQA huggingface dataset:
Protein: SYT_STAMF
Sequence: MRILTIHARKFHYKALSQALDKPEELTNENKEGFFENVLVVFTSVEEGDNEKVVEKAVTEILDIANRVKPKTILLYPYAHLSSDLASPSQALEIMKLLEQKLRGKTDLEVYRAPFGWYKEFMLDCYGHPLSELSKTIRITGGGEVVRRELKKEFYILTPDGKVYDPEKFNYDKYPDLKILVDKEVFGKELPGGVNRVNDYCRKFGFEWEPMSDHGHMRYGPHAVIIMESIMQYSWNIVRSLGIPVYKVMGTNMFNLSEKPVLEHALLFGDRLYELKVDNEKFVLRYAACHQQFAMLRDWIISYKNLPFGMFEVADSYRLEQRGELNLCFRLRKFYMPDLHILNRDLNEAIKISRIVQDKILEEIAKIGRKYVALYNVTSDFFDKYRDILIEFVRRENYPVLVSVIPSGIYYWVLNVEYHIIDNLNRPREIATFQIDIGNGERFNITYTDEKGEKHHPVIIHTAIIGGIERFIYTIFDTAALMEKEGKTPYIPTWLAPVQVRIIPIKNEYLDYAEKVAEKIENAGFRVDIDDRGESLGKKIRDAGREWIPYIVVIGEREVRSNTINVRIRRTNDQKVMVTDELIRILEEETKNYPRVSLTMPKYLSKRPIPSYHA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_CHLTA
Sequence: MDYYTILGVAKTATPEEIKKAYRKLAVKYHPDKNPGDAEAERRFKEVSEAYEVLGDAQKRESYDRYGKDGPFAGAGGFGGAGMGNMEDALRTFMGAFGGDFGGNGGGFFEGLFGGLGEAFGMRGGSESSRQGASKKVHITLSFEEAAKGVEKELLVSGYKSCDACSGSGANTAKGVKVCDRCKGSGQVVQSRGFFSMASTCPDCSGEGRVITDPCSVCRGQGRIKDKRSVHVNIPAGVDSGMRLKMEGYGDAGQNGAPAGDLYVFIDVEPHPVFERHGDDLVLELPIGFVDAALGIKKEIPTLLKEGTCRLSIPEGIQSGTVLKVRGQGFPNVHGKSRGDLLVRVSVETPQHLSNEQKDLLRQFAATEKAENFPKKRSFLDKIKGFFSDFAV
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_CRIGR
Sequence: MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITSEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG
What are the official names of this protein?
40S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: FRSA_ECO55
Sequence: MTQANLSETLFKPRFKHPETSTLVRRFNHGAQPPVQSALDGKTIPHWYRMINRLMWIWRGIDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWATQAMVWQQKACAEEDPQLSGRHWLHAATLYNIAAYPHLKGDDLAEQAQALSNRAYEEAAQRLPGTMRQMEFTVPGGAPITGFLHMPKGDGPFPTVLMCGGLDAMQTDYYSLYERYFAPRGIAMLTIDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLESPRLKAVACLGPVVHTLLSDFKCQQQVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGYWKNDPFSPEEDSRLITSSSADGKLLEIPFNPVYRNFDKGLQEITDWIEKRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: ARGB_METTP
Sequence: MKKEQVLIEALPYIREFYDSIMVIKIGGSIMTNHEILENFIQDIILLKYIGIHPVVVHGGGPEISETMKRLGKKAEFVAGLRVTDRETLEIARMVLLGNINAELVSLIGKHGGKGIGLSGKDGMLIVARKKPPMNVNGENVDLGYVGEVEEINPEILMITAGKGYIPVISPIAIDRDGNSLNVNADTVAGAVAVALRAKKLISITDVEGVREDPDDPGRVISQFSPSEFQRLVERGIIKGGMIPKVEACVRAVERGVEKAHIIDGRIPHAIILELLTDAGIGTMISNIT
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SL9A9_RAT
Sequence: MAGQLRLTSGKDEDHFQHQGAVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVYNCGKLLFSPSTLLVNITDQVYEYKYQREINQHNISPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDTAAFFQSVGNFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDESLKEEPSSQQEANKVDKDMTKTESAQLFRMWYGFDHKYLKPILTHSGPPLTTTLPAWCGPVSRLLTSPQAYGEQLKEDDVECIVNQDELAMNYQEQSPTSSSPATKLALDQKSSGLTLGKENIYEGDLGLGGYELKLEQTRGQPQMD
What is the function of this protein?
Endosomal Na(+), K(+)/H(+) antiporter.  Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+).  By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification.  Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (By similarity).  Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity).  Regulates synaptic transmission by regulating the luminal pH of axonal endosomes.  Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages.  Can also be active at the cell surface of specialized cells, e. g. , in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity).
What are the official names of this protein?
Sodium/hydrogen exchanger 9, Na(+)/H(+) exchanger 9, NHE-9, Sodium/hydrogen exchanger, Solute carrier family 9 member 9.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein: ASTE_SALG2
Sequence: MDNFLALTLSGTTPRVRQGKGAGFRWRWLSHGLLELTPDAPVDRALILSAGIHGNETAPVEMLDKLLSALYSGSLTLTWRVLVVLGNPQALAAGIRYCHSDMNRMFGGRWQSFAESDETRRARELELSLDTFFSSGQARVRWHLDLHTAIRGSHHLRFGVLPQRDRPWETDFLAWLGAAGLEALVFHQAPGGTFTHFSSEHFGALSCTLELGKALPFRQNDLTQFNVTSQALSALLSGVETSTSFSPPLRYRVVSQITRHSDKFALYMDAQTLNFTAFAKGTLLAEEGDKRVTVTHDVEYVLFPNPSVACGLRAGLMLERLP
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: VATE3_METHJ
Sequence: MSVETIINRIREEAEAEIRTIRAEEACDVGAIRAQAEQKAENAYNHRIAEGQREIRQLIASQESRTRIEAKRKVREVREEMLRQCFDEVSSYLKTIRTRPEYPSFLEAMITESAKNLGPSDIAVKVHPDDRRLAADSISRINQEGFSLILSEEPIITSGGVICERISDRVVIDNTVEVRFVRLEREMIVAASRILFHGER
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E 3, V-ATPase subunit E 3.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: LGT_TROW8
Sequence: MHFYIPPPPISGFWLGPLYVHMYSVFMLAGALVLFELTNRRFIVLTGNREFTAFAVTSLLIPVILGARLWHVVSHTQMYEHQPFYKVFAIWQGGLGFIGGVFSGLICFFVIAKIKKVPPFTFLDALAPGILVALCFARLGNYFNGEVFGTETTLPWGLKLSHEGFKDLNVEKYFHPIFLYEIILNVFIIVILLVLEKRVFVKTVFPKGSVFAAFLVLYGLGRFALEPMRYNLQQNSFGLDLNYVGAAAMIIVGVLIACRHTIASGKLRNSGD
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YBHG_ECO81
Sequence: MMKKPVVIGLAVVVLAAVVAGGYWWYQSRQDNGLTLYGNVDIRTVNLSFRVGGRVESLAVDEGDAIKAGQVLGELDHKPYEIALMQAKAGVSVAQAQYDLMLAGYRDEEIAQAAAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLRQYRSGNREQDIAQAKASLEQAQAQLAQAELNLQDSTLIAPSDGTLLTRAVEPGTVLNEGGTVFTVSLTRPVWVRAYVDERNLDQAQPGRKVLLYTDGRPNKPYHGQIGFVSPTAEFTPKTVETPDLRTDLVYRLRIVVTDADDALRQGMPVTVQFGDEAGHE
What are the official names of this protein?
UPF0194 membrane protein YbhG.
What is the protein family that this protein belongs to?
Belongs to the UPF0194 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LDH_MALP2
Sequence: MKTRKVVLIGCGAVGTSFLYSALNQGLFDEYVLIDAFDNLSKGNAWDFEDANAIMSTPAGMIKSGTYEDCADADVVVITAGVPQKPGGETRLQLVGRNAKIMEEIATNVKDSGFDGITVIASNPVDIMGSVYAKVTGFEPNKVIPSGTILDSARLQWEVAKRIKINPASLEVYVVGEHGDSSVSVFSQASVGSIPLSKYRKFSDSQKRAIHKDVMRKAYKIINTKRATFYGIGACLARICKAVLRDENVILPVSIKKNADSDIYIGWPAVVGKDGWHSPLKLTLLAEEKRGFQKSYNSLKKVFEVTWSELGRSEY
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPE14_MYCTU
Sequence: MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQAEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIGLYGNAGGLGPTQGHPLSSATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTALNGMPAGLLSGMALASLAARGTTGGGGTRSGTSTDGQEDGRKPPVVVIREQPPPGNPPR
What are the official names of this protein?
Uncharacterized PPE family protein PPE14.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: SSRP_PROM9
Sequence: MAKNSNKVRKNTNKENNFKRLAENRYAKFQYAISETIEAGIELLGTEVKSIRNGKANLRDGYCSFRDGEILLLNVHISPHKNVGSFFNHDPLRNRKLLLHKKEIIKLKSNTEKKGMTIVPLSMYLKGSWIKLTLGVGKGKKLHDKRQDEKQKSIKKEINSVLKR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: LEXA_SALDC
Sequence: MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVLEIVSGASRGIRLLQEEEDGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPSADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFTPIVVDLREQSFTIEGLAVGVIRNGEWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: KBAY_ECOLC
Sequence: MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires KbaZ subunit for full activity and stability.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Ketose 1,6-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily.
Protein: ILVD2_CUPPJ
Sequence: MPAYRSKTSTAGRNMAGARSLWRATGMKDDDFNKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTKAVEFKKLDLVDAMVIAADPAYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKRAGSRIVELARQYYEQEDARVLPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAQEAGIDFSMNDIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPSLGDALNQWDIVRTKDEAVRHFYMAGPAGIPTQVAFSQNTRWPSLDLDRAEGCIRSYEHAFSKEGGLAVLRGNIALDGCVVKTAGVDESILVFEGSAHVTESQDEAVENILNDKVKAGDVVIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRTIDVLVSDEELARRREEQNAKGWKPAKARPRKVSAALKAYAKLVMSADKGAVRDLSLLDD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase 2, DAD 2.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PI5K6_ARATH
Sequence: MSVAHADDADDYSRPTGESYHAEKALPSGDFYTGQWRDNLPHGHGKYLWTDGCMYVGDWHRGKTMGKGRFSWPSGATYEGDFKNGYMDGKGTYIDSSGDLYRGSWVMNLRHGQGTKSYVNGDCYDGEWRRGLQDGHGRYQWKNENHYIGQWKNGLMNGNGTMIWSNGNRYDGSWEDGAPKGNGTFRWSDGSFYVGVWSKDPKEQNGTYYPSTSSGNFDWQPQQVFYVDLSECVVCTCQRIPVLPSQKMPVWYGASEQSSSGNRTKNSERPRRRSVDGRVSNGEMELRSNGSGYLQVDDNAESTRSSLGPLRIQPAKKQGQTISKGHKNYELMLNLQLGIRHSVGRPAPATSLDLKASAFDPKEKLWTKFPSEGSKYTPPHQSCEFKWKDYCPVVFRTLRKLFSVDAADYMLSICGNDALRELSSPGKSGSFFYLTNDDRYMIKTMKKAETKVLIRMLPAYYNHVRACENTLVTKFFGLHCVKLTGTAQKKVRFVIMGNLFCTGHSIHRRFDLKGSSHGRLTTKPESEIDPNTTLKDLDLNFAFRLQKNWFQEFCRQVDRDCEFLEQERIMDYSLLVGLHFREAAIKDSATPTSGARTPTGNSETRLSRAEMDRFLLDASKLASIKLGINMPARVERTARRSDCENQLVGDPTGEFYDVIVYFGIIDILQDYDISKKLEHAYKSMQYDPTSISAVDPKQYSRRFRDFIFRVFVEDA
What are the official names of this protein?
Phosphatidylinositol 4-phosphate 5-kinase 6, AtPIP5K6, 1-phosphatidylinositol 4-phosphate kinase 6, Diphosphoinositide kinase 6, PtdIns(4)P-5-kinase 6.
Protein: TYSY_AGRFC
Sequence: MKQYLDLLRHVMETGSDRGDRTGTGTRSVFGYQMRFDLSEGFPVLTTKKLHLRSIIHELLWFLNGDTNIAYLKENGVSIWDEWADENGDLGPVYGAQWRSWPAPDGRHIDQIALLIEALKTNPNSRRHIVSAWNPALVDEMALPPCHCLFQFYVSDGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVVGLKPGDFVHTLGDAHIYANHFEQAQLQMTRTPKALPTMRLNPDVKNLFGFKFEDFTLENYEADSSIKAPIAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHZ1_LODEL
Sequence: MSEREVKQIHEDQEAANAPAGLAQENAQVEETANENGSEDVSSAKKRDPEEDVTKADEPDKKKKKKRRTYDDDDDKEEKDGEEVKGKEAAKEKDSEGKEKVDADDDDEDEEDEEAEVVLGEDDEDDDDDDDEDDDEEYDESRADVGEEDDEEEDELNEIDQSNIISSGRRTRGKQIDFNEAAEKLDRENGLLEEDGEEEN
What is the function of this protein?
Forms a chaperone-bound H2A. Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A. Z histone replacement in chromatin.
What are the official names of this protein?
Histone H2A.Z-specific chaperone CHZ1.
What is the protein family that this protein belongs to?
Belongs to the CHZ1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CRCB_MAGMM
Sequence: MQIAWVALGGAIGAVARYVLSNAVYAWLGRAFPWGTLSVNLLGSFIMGLLFYLFTQRLMVPEALKPLVLVGGLGAFTTFSTFSLETLNLMQSGSWSLALLNMLSSVLLCVLAAYLGLVVGRLI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURB_RHOPA
Sequence: MSFPDITPELKAAMPELRGRLLSNEPLAPLTWFRVGGPAQVLFTPADEDDLGYFLPRLPAEIPVMCLGLGSNLIVRDGGLPGVAIRLSPRGFGEHRVEGEMVHAGAAALDKRVAETAAAAQLGGLEFYYGIPGSIGGALRMNAGANGRETKDVLIDATAYDRSGTRKLFDNAAMQFSYRHSGADPALIFTSARLRGTPATPDHIRAKMNEVQAHRELAQPIREKTGGSTFKNPPGQSAWRLIDAAGCRGLKIGGAQVSEMHCNFLINTGEATAADIETLGETVRARVKAQSGVELQWEIKRIGVAPGKG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHA_ECO57
Sequence: MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNTHEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNLKNHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGIAGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNRWNNNRNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQLKVIRERLKNARLDDTSSEFNTQRVECLELDNLMETAYATAVSANFRTESRGAHSRFDFPDRDDENWLCHSLYLPESESMTRRSVNMEPKLRPAFPPKIRTY
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.
What are the official names of this protein?
Succinate dehydrogenase flavoprotein subunit.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MURG_THEMA
Sequence: MIKVAAAGGGTGGHLYPLLAILETLAKRVDVKVLFFAVKGKIDERVVRKDHPEFETVSIDVRGLLRPLHHPKNLWRTLKIGIATIEVKKHLKRFKPDLVVLTGGYISGVVGLAAKDLGIPIFVHEQNVVPGLAVKVLSQYAKKVFVSFERTRDYLREWQDKIVVTGCPVRETEKEAPLKDFVLVLGGSLGSEAINELMEKVYPELQETQFVHSTGSDDWTERLSVFPNVTALTYIDPMGAYWKKAIASISRAGASTIAEMMYYGVPGILIPWESSAESHQLENALEAERLGYAIVIRENEASPRKIIESIDKVVKKGKIEKMKENPASKISKEILGEIM
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PSBF_BETVU
Sequence: MTIDRTYPIFTVRWLAVHGLAIPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y657_MYCPN
Sequence: MDWLKRWFTRKDQDKTETTSASKRAKITSSLLMFSALYEAKKPLKYTIVYILALVNAFFLLVFIQQTGLYSFGISSLTQGFARLLFVLLKNLEDGQRNLVFNIFYWLFYVIVNIPLIIFSYKKIGKRFTILSTHYVVASNVFGFIFSIIPGANQLPSMLSAVHHTEFWEDAKKAEGVDQSALFVPFLWNDTSQGNVIISTFIYAGIYGFVNGTSLAILYILGSCAGGADFLTQYFARKKNRSVGPILFYVNTFILIIAILMGSFVAGSIVLQDIPDYKKSAWQVNLFFSPNLIATFFSVLFTGTVVSHLFPRYNFAEIKVFTDKIEEVRLALLNDKATHSLSIQETMGGYSLAKKRMIVSVTMYVEIPNLIRIIRKIDKDCLVSITRIRGIDGYIYLRSQD
What are the official names of this protein?
Uncharacterized protein MG443 homolog.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NODF_RHIME
Sequence: MVDQLESEIIGIIKNRVESEGGDGETALIVGDLTAATELTALGVDSLGLADIIWDVEQAYGIRIEMNTAEAWSDLQNVGDIVGAIRGLLTKGA
What is the function of this protein?
Proposed to synthesize nod factor fatty acyl chain.  Involved in trans-2,trans-4,trans-6,cis-11-octadecatetraenoic acid biosynthesis.
What are the official names of this protein?
Nodulation protein F, Host-specificity of nodulation protein A.
Protein: LESV_ARATH
Sequence: MALRLGVSIGAALGSSHWDDGQRVRQRDFSASVNFTAPVTSRRSLRGSRTGVRILRVSNEGRESYLDMWKNAVDREKKEKAFEKIAENVVAVDGEKEKGGDLEKKSDEFQKILEVSVEERDRIQRMQVVDRAAAAISAARAILASNNSGDGKEGFPNEDNTVTSEVTETPKNAKLGMWSRTVYVPRSETSGTETPGPDFWSWTPPQGSEISSVDLQAVEKPAEFPTLPNPVLEKDKSADSLSIPYESMLSSERHSFTIPPFESLIEVRKEAETKPSSETLSTEHDLDLISSANAEEVARVLDSLDESSTHGVSEDGLKWWKQTGVEKRPDGVVCRWTMIRGVTADGVVEWQDKYWEASDDFGFKELGSEKSGRDATGNVWREFWRESMSQENGVVHMEKTADKWGKSGQGDEWQEKWWEHYDATGKSEKWAHKWCSIDRNTPLDAGHAHVWHERWGEKYDGQGGSTKYTDKWAERWVGDGWDKWGDKWDENFNPSAQGVKQGETWWEGKHGDRWNRSWGEGHNGSGWVHKYGKSSSGEHWDTHVPQETWYEKFPHFGFFHCFDNSVQLRAVKKPSDMS
What is the function of this protein?
Binds preferentially to highly ordered alpha-glucans, such as starch and crystalline maltodextrins (PubMed:35665549).  Involved in the organization of the starch granule matrix, thus influencing starch turnover by modulating the accessibility of starch polymers to modifying and degrading enzymes involved in phosphorylation, hydrolyzes and synthesis, including starch synthases (SSI and SSIII), starch phosphorylases (PHS1), isoamylase, beta-amylase, glucan water dikinase (GWD) and phosphoglucan water dikinase (PWD) (PubMed:27207856, PubMed:35665549).
What are the official names of this protein?
Protein LIKE EARLY STARVATION, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the ESV1 family.