PharMolix/UniProtQA huggingface dataset:
Protein: PNP_BURMS
Sequence: MSLFNKIVKEFQWGQQKVRLETGEIARQASGAVIVDIEDTVVLATVVGAKSAKPGQDFFPLTVDYIEKTYSAGKIPGGFFRREGRPSEHETLTSRLIDRPLRPLFPEGFYNEVQVVIHVLSVNPEIPADIPALIGASAALAVSGLPFNGPVGAARVAYVNNEYVLNPTREQIKASRLDLVVAGTERAVLMVESEADQLPEDVMLGAVVFGHEQMQTAIDAIHELVREGGKPEWDWQPAPKDEALNARVTELAQPELLAAYQIRDKQARLTKLKEVYAATSAKLEEEAVAAGTVAADKATVGNILFDLEAKIVRGQILNGEPRIDGRDTRTVRPIEIRTGVLPRTHGSALFTRGETQALVVATLGTKGDEQIIDALEGEYRERFMLHYNMPPFATGETGRVGSPKRREIGHGRLAKRALVACLPSADEFGYSIRVVSEITESNGSSSMASVCGGCLALMDAGVPMKAHVAGIAMGLILEGNKFAVLTDILGDEDHLGDMDFKVAGTADGVTALQMDIKIQGITKEIMQVALAQAKEGRMHILGKMKDAVAGANTQLSEFAPRMITIKINPEKIRDVIGKGGSVIRALTEETGTTIDISDDGVVTIASTNSEGMAEAKKRIENITAEIEVGHVYEGTVLKLLDFGAIVNLLPGKDGLLHISEIVNERVKDINDYLKEGQQVKVKVIQTDEKGRVRLSAKALLNEAAAQADTPPQQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASP22_YEAST
Sequence: MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG
What are the official names of this protein?
L-asparaginase 2-2, L-asparaginase II, L-asparagine amidohydrolase II, ASP II.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family.
What are the subcellular locations of this protein?
Secreted. Periplasm.
Protein: SKN7_CANAL
Sequence: MSSLQQPIPPNSTLATTASSNQSGSNDFVKKLFLMLQEDSYKEVVRWTVKGDSFVVINTNEFTKDILPKHFKHSNFASFVRQLNKYDFHKVKISNEAKASYPYGEDAWEFKHPEFRINDAEALENIKRKGPTAKKSASNVTIKTEANNNGTQPTCNHNYSQLVSATNHLKEQVESLKNDKHSLYQEISVLERKYKTVVENIVAINTFNERYYRSMNVLINSIVQNGMKLPPLDFPPPVQLGPDSGIGSNLGPISSDTALPSISHHLSSPLPHHQQLLNRTIRPISSPIDGIPLVKLQQQSLGQNLQAPIGTPSAVPFSEEASSSIQAATPAPLAQPVAQPINQPPPPPPPPATQQQPLPPPPPPATATSQIPSAPPPPTQQQVGTSSSSVPTISPKSQGIVVSNSASPTTSAQISTTSVPNPKFHVLLVEDDNVCIQLCRKFLVKYGCSVTVVTDGLNAISTVEHTKYDLVLMDIVMPNLDGATATSVIRSFDTKTPIIAMTGNIEDNDLVTYLQNGMSDILAKPFTKDDLYAILSKHLLDPKENKQDNEPTVKKQKLS
What is the function of this protein?
Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment.  Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1.  Also activated in response to oxidative stress, independent on the two-component regulatory system.  Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.
What are the official names of this protein?
Transcription factor SKN7.
What is the protein family that this protein belongs to?
Belongs to the SKN7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TSAD_WOLTR
Sequence: MKTILAVETSCDETAVAIVNSEKQVLAQEILSQTEHKKRGGVIPEIASRAHMEHLSSLIKNSIEKSNLNFCNLDATAATSGPGLIGGLIVGTMMAKAIAHVTQKPFIAVNHLEAHVLVIRLLYEVKFPFLVLLISGGHCQFLIAQNVGKYIKLGETLDDSLGEAFDKVARMLGLSYPGGPLIEKLAKKGNGTRFKLPRAMRKRPGCNFSFSGIKTAVKNLVQELEMSEQDVCDVCASFQECISEILLDRVKNAVIMAESLNIKINDFVVTGGVAANNFLRKKLKKHINLNILFPPINLCTDNAVMVGWTGIEILQKDYIDSLNFAPRPRWELGSY
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTF2_MOUSE
Sequence: MYCLLATPLCLLSLLLPPLSPAAPISPSEPIGQAYSLALYMQKNTSALLQTYLQHQGSPFSDPGFSAPELQLSTLPSAAVSFKTWHAMEDAERLSRAQGAFLALTQHLQLVGDDQSYLNPGSPILLAQLGAARLRAQGLLGNMAAIMTALGLPIPPEEDTLGFVPFGASAFERKCRGYIVTREYGHWTDRAVRDLALLKAKYSA
What is the function of this protein?
Increases the platelet count associated with splenomegaly.  May have an important role in neuronal precursor development and maturation.
What are the official names of this protein?
Cardiotrophin-2, CT-2, Neuropoietin, Np.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL19_ACIAC
Sequence: MNLIQTLEQEEIARLNKTIPEFAPGDTVIVSVNVVEGNRKRVQAYEGVVIAKRNRGLNSGFTVRKISSGEGVERTFQTYSPLIASIEVKRRGDVRRAKLYYLRDRSGKSARIKEKLPSRVNKAAATAA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: GLGC1_VIBVY
Sequence: MAGVLGMILAGGEGSRLRPLTESRSKPAVPFGGSYRLIDFALNNFVNADLMRIYVLTQFKSQSLFHHMKKGWNINGITDRFIDPIPAQMRTGKRWYEGTADAIYQNLRFMELSEPEQVCIFGSDHIYKMDIKQMLSFHKEKQAALTVSALRMPLAEASQFGVIEVDAEGRMVGFEEKPSAPKSIPGDPDFALVSMGNYIFEADVLFAELIEDADNENSSHDFGKDIIPKMFPRGDVFVYDFSQNRISGEKAEVYWRDVGTIDAYWQAHMDLLKTDAPFSLYNRKWPLHTYQPPLPPATFTDSDNGRVQIIDSLVCNGSYVRGSRIEKSVLGFRSNIASACDISESILLGDVKVGEGCVLRRVIVDKDVDIAPGTQIGVNLQEDKKVFHVSDDGIVVIPKGARVGY
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase 1, ADP-glucose pyrophosphorylase 1, ADPGlc PPase 1, ADP-glucose synthase 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: ATPE_PHAAO
Sequence: MTLNLCVLTPNRMIWDSEVKEIILSTNSGQIGVLPNHAPIATAVDIGLLRIRLKDRWLTVALMGGFARISNNEITILGNGAEISTDIDPQEAQQTLEIAEANLSKAEGKRQAIEANLALRRARTRVEAIKVISS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: FTSH4_ORYSJ
Sequence: MAWRRVLSQLARSRPASTIYNELITSRPSWLLRGDVNGGGTLKNLNERYQSSFVGSLARRVQNLDVPSEASLLKEIYKSDPERVIQIFESQPWLHSNRLALSEYVKALVKVDRLDDSTLLKTLRRGMAVSGGEGERVGSSSALKSAGQATKDGILGTANAPIHMVTSETGHFKDQIWRTFRSLALTFLVISGIGALIEDRGISKGLGLSQEVQPIMDSKTKFSDVKGVDEAKAELEEIVHYLRDPKRFTHLGGKLPKGVLLVGPPGTGKTMLARAVAGEAGVPFFSCSGSEFEEMFVGVGARRVRDLFAAAKKRSPCIIFMDEIDAIGGSRNPKDQQYMRMTLNQLLVELDGFKQNEGIIVIAATNFPQSLDKALVRPGRFDRHIVVPNPDVEGRRQILESHMLKVLKSDDVDLMIIARGTPGFSGADLANLVNVAALKAAMDGAKAVTMNDLEYAKDRIMMGSERKSAVISDESRKLTAYHEGGHALVAIHTEGARPVHKATIVPRGRTLGMVSQLPEKDETSFSRKQMLAWLDVSMAGRVAEELIFGDSEVTSGASSDFQNATKMARAMVTKYGMSKQLGFVSYNYEDDGKSMSTETRLLIEQEVKSLLENAYNNAKTILTKHSKEHHVLAQALLEHETLTGAQIKKILAQANSTQQQQEHAVEAPRKTPAAPSSPAASAAAAAAATAAAAAKQAAAKAKGVAGIGS
What is the function of this protein?
Probable ATP-dependent zinc metallopeptidase.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FTSH 4, mitochondrial, OsFTSH4.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MMP10_RAT
Sequence: MEPLAILVLLCFPICSAYPLHGAVRQDHSTMDLAQQYLEKYYNFRKNEKQFFKRKDSSPVVKKIEEMQKFLGLEMTGKLDSNTVEMMHKPRCGVPDVGGFSTFPGSPKWRKNHISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFYPFDGVGQSLAHAYPPGPGFYGDAHFDDDEKWSLGPSGTNLFLVAAHELGHSLGLFHSNNKESLMYPVYRFSTSQANIRLSQDDIEGIQSLYGARPSSDATVVPVPSVSPKPETPVKCDPALSFDAVTMLRGEFLFFKDRHFWRRTQWNPEPEFHLISAFWPSLPSGLDAAYEANNKDRVLIFKGSQFWAVRGNEVQAGYPKRIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDETRQLMDKGFPRLITDDFPGIEPQVDAVLHAFGFFYFFCGSSQFEFDPNARTVTHTLKSNSWLLC
What is the function of this protein?
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V.  Activates procollagenase.
What are the official names of this protein?
Stromelysin-2, SL-2, Matrix metalloproteinase-10, MMP-10, Transformation-associated protein 34A, Transin-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: ASNA_SALTY
Sequence: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAEVHKQFGLAPFLPEQIQFVHSQELLARFPDLDAKGRERAIAKELGAVFLVGIGGKLSDGHRHDVRAPDYDDWSSASELGYAGLNGDILVWNPVLEDAFELSSMGIRVDADTLMRQLALTGDEDRLQLEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAQVRESIPAIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGF1_SHEEP
Sequence: MAEGETTTFRALTEKFNLPLGNYKKPKLLYCSNGGYFLRILPDGRVDGTKDRSDQHIQLQLYAESIGEVYIKSTETGQFLAMDTNGLLYGSQTPSEECLFLERLEENHYNTYISKKHAEKNWFIGLKKNGSSKLGPRTHFGQKAILFLPLPVSSD
What is the function of this protein?
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration.  Functions as potent mitogen in vitro.  Acts as a ligand for FGFR1 and integrins.  Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades.  Binds to integrin ITGAV:ITGB3.  Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling.  Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1.  Can induce angiogenesis.
What are the official names of this protein?
Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, aFGF, Heparin-binding growth factor 1, HBGF-1.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 (By similarity).
Protein: SBNA_STAAM
Sequence: MIEKSQACHDSLLDSVGQTPMVQLHQLFPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGANVEMVEEPDAHGGYLMTRIAKVQELLATIDDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRKIKEVHPNAQIVAVDAKGSVIFGDKPINRELPGIGASRVPEILNRSEINQVIHVDDYQSALGCRKLIDYEGIFAGGSTGSIIAAIEQLITSIEEGATIVTILPDRGDRYLDLVYSDTWLEKMKSRQGVKSE
What is the function of this protein?
Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) from O-phospho-L-serine and L-glutamate.  Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
What are the official names of this protein?
N-(2-amino-2-carboxyethyl)-L-glutamate synthase, ACEGA synthase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.
Protein: TDH_BURP6
Sequence: MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGVMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMSGVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAVDDYEKGFAAMLSGESGKVILDWADA
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2B_BOTNI
Sequence: NLLQFNRMIKLETKKNAVPFYAFYGCYCGWGGQGQPKDATDRCCFEHDCCYGKLTKCNTKSDLYSYSSKYGFLLCGKGTWCEEQICECDRIAATCLRRSLDTYKLKYMFYLDSYCKGPSEKC
What is the function of this protein?
Subunit B: Snake venom phospholipase A2 (PLA2) that induces myonecrosis in mice.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 nigroviriditoxin basic subunit B, Ngvtx-B, svPLA2, Phospholipase A(2).
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MUTL_RICFE
Sequence: MTIKFLSESTINRIAAGEVIERPASVVKELVENAVDAGSTKIDIILERAGKNLIIISDDGIGMTDKELEIAVERHTTSKLDESDFLNIHTFGFRGEALPSIAAISKMLITSKKQGADKAFQIKLIGGNEKQVTVSVHNEGTKIEIRDLFFATPARLKFLRADKTELAATVDVVKKIALAHPEISFSLTHDDRNLLKFKGQNKDAETNLKQRIIDVIGDDFIKNAAYIDFKTPDFSICGYTSIPTYNRASSEDQFLFINNRPVKDKLLQVALRVAYQDYLARDRYPLCAIFLQIDPQLVDVNVHPAKAEVRFHDPNYVRNLLIEAIKNALTNKSHVTSTTIASDALQLFKNPLVNKQPSVSKAVSVNSKPADYRPAMSPSFKPTPNTACQKLIDTLPHAKIEQEVERRIEHEQQVHKQYKLGAAKAQLHTTYIISQTEDSIVITDQHAAHERLGYEKIKDYLKTEELIKQRLLIPEIVELPNERKADCLYENREKLYKLGLTLEKFGEKSIIVTEIPNILEDVNVQKLIQDLADHLSDFGENIALTELIEHVTETYACHYSIRAGRKLSADEMNALLRQMENTPFSGQCNHGRPTYIELKLKDIERLFGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RPOC_PSYWF
Sequence: MKDLLDIMKSPADNGKREFDSIQITLAAPETIKSWSHGEVKKPETINYRTFKPERDGLFCAKIFGPVKDFECLCGKYKRRKFQGVICEKCGVEVTTAKVRRDRMGHIDLASPVAHIWFLKSLPSRIGLLLDMTLRDIERVLYFESYVVTDPGMTSLEKYQLLDDEDYYKALEEFGDEFIAKMGAEAVQDLLKDIDIDLEIDDLREAIPNTGSETKLKKMSKRLKLLEAFRDSNNKPEWMVMSILPVLPPDLRPLVPLEGGRFATSDLNDLYRRVINRNNRLKRLLELNAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPTLRLHQCGLPKKMALELFKPFTYSKLLSHGMATTIKQAKKMVEREEPQVWDMLAMVIREHPVLLNRAPTLHRLGLQAFEPVLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLTLEAQLEARTLMMSTNNILSPANGDPIIVPSQDVVLGLYYISRSAVNAKGEGMIFATVNEALRAIGSNDLHVNAKIKVRVTETIFDEEGNSTKQTTLQETVAGRLLIWNVMPKGMRFAECNVEMTKKNISKLMNSCYRTRGVKESVIFADQLMYLGFAQATLSGVSIGIEDMVIPPMKKELIEAADAEVREIEQQFEQGFVTAGERYNKVVDIWSRTNDKVAKAMMDNLATDIVINAQGEEEEQKSFNSIFIMSDSGARGSAAQIRQLAGMRGLMAKPDGSIIETPIKANFREGLSVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVITENDCGTEKGVRMTPHIQGGEIIEKLGDRVLGRVVARDVMSREDEVLLAAGTLIDEHGVTVIDDNGIDEVWVRSVITCDVPHGVCAQCYGRDLARGHKVNIGESVGVMAAQSIGEPGTQLTMRTFHVGGAASSTSVDNSISARNTGFIRFHNMKTVDHVDGHLVIVSRSAEIGIADDVGRERERYKVPYGSSVLVKDGDEVESGQAIAKWDPHTHPIITEFAGKARFSDIIDGSTATVKIDEATGMSSFEILGSKDRPSNSKDLRPAIILDTTGGKEVVYFLPAETIIRVSDGEEVTAGSVLGRVPQATSGTKDITGGLPRVADLFEARRPKDHAIMAEMSGVVSFGSSTKGKNRFIITNEDGEVHEELIPKWRQINVFENETVARGEVIADGPLNPHDILRLQGETALANYIVDEVQDVYRLQGVKINDKHIEVIIRQMLRKVEITDAGDSNYFKGDQVEYADVKATNEKLLAEDKFPVQFERQLLGITKASLATESFISAASFQETTRVLTAAAVEGKVDELRGLKENVVVGRLIPAGTGLAYHAARKKAKEGKPAYDVESALDAAFDIEATTSAQDFRSFDEAFAQELSQDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: CCD22_MOUSE
Sequence: MEEADRILIHSLRQAGTAVPPEVQTLRAFTTELVVEAVVRCLRVINPDVGSGLSHLLPPAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPSDASEDADQPAGDSAIFLRAIGSQIRDQLALPWVPPLLRTPKVQRLQGSALQQPFHSSRLVLPELNSSGELWEFQASPLLLPAPTQVPQLQGRAASLLEHHASQLCQHVNRDCPGDEDRVRWASRVPSQEDSRAPQQRLHKQLIEHLRQSWGPLGAPTQVRDLGEMLQTWGARAMTGVPKGSRFTHSEKFTFHLEPQVQAAQVADVPATSQRLEQDTRAAQEQELESLREQLASVNHNIEEVEADMKTLGINLVQVETECRQSELSVAEQEQALRLKSRTVELLPDGAANLAKLQLVVESSAQRLIHLASQWEKHRVPLLAEYRHLRRLQDCRELESSRRLAEIQELHHSVRAAAEEARRKEEVYKQLVSELETLPKDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETEMGKKTLSNLEKICEDYRALRQENAGLLGRVREA
What is the function of this protein?
Involved in regulation of NF-kappa-B signaling.  Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex.  May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex.  Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10.  Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels.  The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1.  Plays a role in copper ion homeostasis.  Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.
What are the official names of this protein?
Coiled-coil domain-containing protein 22.
What is the protein family that this protein belongs to?
Belongs to the CCDC22 family.
What are the subcellular locations of this protein?
Endosome.
Protein: RRT14_YEAS7
Sequence: MSSSLSQTSKYQATSVVNGLLSNLLPGVPKIRANNGKTSVNNGSKAQLIDRNLKKRVQLQNRDVHKIKKKCKLVKKKQVKKHKLDKEQLEQLAKHQVLKKHQQEGTLTDHERKYLNKLIKRNSQNLRSWDLEEEVRDELEDIQQSILKDTVSTANTDRSKRRRFKRKQFKEDIKGSDFVKDHRYPGLTPGLAPVGLSDEEDSSEED
What is the function of this protein?
Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription 14.
What is the protein family that this protein belongs to?
Belongs to the RRT14 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HCP_SHELP
Sequence: MFCIQCEQTIRTPAGNGCSYSQGMCGKLAATSDLQDLLIYILQGVSAYAEKARAFGIIVPAIDTFVPKAFFATLTNVNFDDERIMAYTQQAYGYRAQLQAAYESACKAQGQAIETLIPAASLVLASVKEEMLALAAQALPNRGKEEVNEDIMGLRLLCLYGLKGAAAYMEHARVLDQTDSEVAAKFHEIMAFLGSDSVDADKLFATAMEIGQLNYRVMAMLDEGETQAFGHPEPTQVNTVAVKGKAILVSGHDMKDLELILQQTEGKGINVFTHGEMLPALAYPELKKYPHLVGNYGSAWQNQQKEFANFPGAVVMTSNCIIDPNVGDYADRIFTRSIVGWPGVTHIVGDDFSAVIDKALSLEGFAYDEIPHHITIGFARNALMAAAPAVVENVKNGSIKHFFLVGGCDGDKAERSYFTDIAKAAPKDSIIMTLGCGKYKFNKLAFGDINGIPRLLDIGQCNDAYSAIQLAIALSEVFECEINELPLSLVLSWFEQKAIVILLTLLSLGVKNIRTGPSAPAFLTPNLLKVLEDKFGLRSTTTVEQDLNAILNVA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_LEPBL
Sequence: MARSVKKGPFIDDHLMKKITKLNSENQKKPFKTWSRRSTIFPDMVGHTVMVHNGKQFTPVYINENMIGHKLGEFSPTRTFRGHVAGDKKAAKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: PURA_DELAS
Sequence: MKATKGRNVVVVGTQWGDEGKGKLVDWLTESAQGVVRFQGGHNAGHTLVINGVKTALHLIPSGIMRPGVKCYIGNGVVLSAAKLFEEIEGLEKAGVQVRDRLRVSEACPLILPFHSALDVAREAAREQGGTEKIGTTGRGIGPAYEDKIARRALRVQDLKYPERFATKLRELLALHNHILVNVLGSKNFTFGDALKPYIKDGEVQFDAVYEEAMRHAELLKPMMADVSRELNAAHAEGANLLFEGAQGTLLDVDHGTYPYVTSSNCVAGNAAAGSGVGPGMLHYILGITKAYCTRVGGGPFPTELDWEKEGTPGWHMSTVGAEKGVTTGRSRRCGWFDAALLKRSAQVNGLSGLCITKLDVLDGLQELLLCVGYELDGEKIDLLPMGADEIARCKPIYESIPGWTDSTVGVTDYDKLPANARRYLERIEEVTGVPIAMVSTSPDRDHTILMQNPYAAQ
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXK_CAEEL
Sequence: MSSSELIAELERERDRRVLSIQSHVVHGYAGNKCSVFPLQLHGFEVDFINSVQFSNHAGNIEYLTLPTRYEHVKGQKLTEKELEELYEGLTLNNINNYTHVLTGYCGNVTFLQKIADVVKDLKKKNGNTTFVCDPVMGDNGRYYTPKELMPVYRDLIIPLADVLTPNAFELGELTGSPIETEEDCLRAVNELHAKGVKTVVVTSGVTGAQTNESLRCYASVKGSHVYRFTFPRLVGQFVGTGDTFTSLLVVWLDELNGDVSEAVKRVLASMQCLIRKTSSYAQLQVDTNSRAMCELRLIQSRKDLLWPPTCDQIQVEKIGQ
What is the function of this protein?
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
What are the official names of this protein?
Putative pyridoxal kinase, Pyridoxine kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family.
Protein: MVHD_METTM
Sequence: MAEDDIKIVMFCCNWCSYGGADTAGTARMQYPTNIRVIRVMCSGRIEPQFVFKAFREGADGVLVTGCHHGDCHYDAGNYKLDRRMRLIYKLADELGIGRERIHHDWISASEGEKFAETVKMMVDRIRALGPSPIKKQLAEA
What is the function of this protein?
Part of a complex that provides reducing equivalents for heterodisulfide reductase.  MvhD may form the contact site to heterodisulfide reductase.
What are the official names of this protein?
F420-non-reducing hydrogenase iron-sulfur subunit D, Methyl viologen-reducing hydrogenase subunit delta, MVH subunit D.
What is the protein family that this protein belongs to?
Belongs to the MvhD/VhuD family.
Protein: RM09_PAPAN
Sequence: MAALVVTEPGRALLRAGTERLLRGGIQELLRPRHEGNSPGLARDFSLSQNRGTVIVERWWKVPLAGEGRKPRLHRRHRVYKLVEDTKHRPKENLELILTQSVENIGVRGDLVSVRKSLGRNALLPQGLAVYASPENKKLFEEEKSLRQEGKLEKLQTKAGEVTVKFLKSCRLEVGMKNNVKWELNPEIVARHFFKNLGVVVAPHTLKLPEEPITRWGEYWCEVTVNGLDTIRVPMSVVNFEKPKTKRYKYWLAQQTAKRMAPTSPQI
What are the official names of this protein?
39S ribosomal protein L9, mitochondrial, L9mt, MRP-L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
What are the subcellular locations of this protein?
Mitochondrion.