PharMolix/UniProtQA huggingface dataset:
Protein: MAO1_PSYCK
Sequence: MLNQRPLYIPFAGPALLETPLLNKGSAFSSEERDSFNLTGLLPHNIETIEEQSSRAYLQLRSFTSDMDKHIYLRNIQDTNETLFHHLIEQHIEEVMPLIYTPTVGQACEKFSQIYRRKRGLFISYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACGGISPAYCLPILLDVGTNNQQLLDDPMYMGWRNPRISGDEYNEFVDLFIQAVKRRWPEVLLQFEDFAQENATPLLNKYRDQLCCFNDDIQGTAAVSVGTLIAACLNKSQKLSQQNIAFLGAGSAGCGIAEHIIRQMQREGLTEEQARRQVFMVDRYGLLTDSMTELQKFQTPLVQKESDIEHWDKSQKLGLAQVVKQARITVLFGVSGQKGLFTQEVVEALCANTEHPIVLPLSNPTSRVEATPQEVTNWSRGKAIVATGSPFPNTTFEGQSYEVSQCNNSYIFPGIGLGVLAARATGISDNMLTAASQALADISVEYEKAPGAILPPIKFIREISEKIAYAVALQAIEDKLALPVTAENLERRLKANFWLPKYRDYRRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: GATC_LACLM
Sequence: MSQITEEQVKHVALLSKLEFSENEVKSFTVTFGKIIDMVEMLDEVDTDGVPFTMNVADNLNFMREDVAEKGLDREKLMAAVPEKEDGFIKVPAMLSDGGDA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: Y788_TREPA
Sequence: MRVRTFCFSLVCALGASTYLLWRGWLQLSLPAGSYGVMRSRSGGYHHALIAPGRFLWRWEPLLPSNAELFAFELKKQTVSVTVQDVLPAAKEYAQLLDQHAPFDWTLALSARVALKEAFLLDTVQRERITDQNSLERYVDTTAQAALTQVSHDFIARCMADPALYERVHTQYGLATRELKRAIEKEIPHCAISEVVLSEVHIPDMVLYHTAEQAYRAFEAKRSEHLSALAQQAAKRSALENFEMQRLTKWGEFFQRYPSVIDFLNAIRQDGASTLETLKKGSTASHRAIPHEETTR
What are the official names of this protein?
Uncharacterized protein TP_0788.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HIS4_RIPO1
Sequence: MDVIPAIDLLDGRCVRLYQGDYQQSQVYNDNPVEVARQWADQGATYLHLVDLDGAKQGKPVNLASIEAIIRGISIPVQVGGGLRDRASIVQLFNLGVDRAIVGTVAVENPTLVKELCAEFPRKIAVGIDARNGKVATRGWLETSEVIATELAQEMAQLGAAAIIYTDIHRDGTLSGPNREALRELASNIEIPVIASGGISSLTDLLGLLSLEPLGVTGVIVGKALYTGDVDLSEALRAIGPGRWQDVPPDIDSSLFG
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNKR_CAEEL
Sequence: MFSTTMGFPSTPLEAKQALGISSGISSVSSGLRSGSPMLSASYEPQLSFARCVEQWKGKEIARWIEGLGDQMNPYLGMIRDNIKSGKQLEALDDDSLKKIGISALGARKTIFQAVSLLLYFCHESEHENLQRLAQQVKTSCLYVERTMTSAMRMREKAIRRSEIVNILNSVSNAVLQLAEHTKRFVFWLDRTPFDEEPEFINVRNSVSSFMWNLLRNVNVQPKALFETGSQIVRMSKELAYECQKIVDCDDPLILYACFIESALLRRRSDNINWGLNIQSSYRGVHVISEIKEGSPADACTKIDAGDEILMINGRTVVGWDLTSVVQQVGALDVLELSLIVKRRPREPQLPKQSKLAARALAPSSQTAKTYSTDDYDPFGQSEPLKRHRSCHVISEIIKENERKIRISRRLIRRSSIASACPRKERKNIDERALDGDDEDDWDVHEFIRNVDGEEEALVPRIAKRTRTMRHQPDGYVRSFIDNKLVTDIEDDVVNDQLTFNVKCPNEFAQIKEVDKEELKVLNLPEARVSDEDWKAPYQEFAAPSFRAVGDSNISGFSLDSPRLLPVSSRMTSSVEESAFGVLPSPSTSSMNSVSSPAPFGKFQMSTSQTEWSPNPDDLPGSPISAAYAGMEKLFEGWVRRRKTRAELNANELTNKWPKIWMCLRGHYLLLYTNQNTKRPEMVINLIKATISDSTDLKTSKKNIFRITAAPLDYHFSCFTALDWRNWTQKMKMAKEIFANAGTQPRIMSQSVSSYNNDLSDQNFFLGQQTGSGLSTLPRVTTNGMTTSKSGGLGGGGFKQK
What is the function of this protein?
Non-essential component of the Ras signaling pathway.
What are the official names of this protein?
Connector enhancer of kinase suppressor of ras, CNK-1, Connector enhancer of KSR.
What is the protein family that this protein belongs to?
Belongs to the CNKSR family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: SYK_RICBR
Sequence: MSEILEDAIKSKAWPFEEAKKILDSLNGKTPEKGYVLFETGYGPSGLPHIGTFGENARMVMVQKAFEQLSNIKTKLICFSDDMDGLRKVPSNIPNPEMVAGYMDMPLTSIPDPFGECESYGHYMNAKLRSFLDKFGFEYEFYSSTEMYKAGMFDEMLIRVLEKYDEIMELMLPTFREERKATYSPFMPICPKTGKVLQVPIHKWDAKLGTITYKDENGETIEVPVTKGHCKLQWKPDFGMRWAALKVDYEMYGKDHLANGRLYSEICRILGEKPPVQLCYELFLDENGEKISKSKGNSISVDDWLKYAPVESMALFMYQNPTRAKRLFFDVIPKNVDEYITFNQKYHLEEDRTKRFANPVYHIHHGNVPKIETFGITYSLLLNLTSVCNPSDKSVLWGFISRYEPKAMPNNSPYLDHLAEFAIRYYNDFVKAHKSYLAPSEKHKAILQDILDMLKGLPEQIEAESIQKGIYDIGMKAGYENLRDYFKDLYQILLGQSDGPRLGTFIKLYGISETMKLIEEKL
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C1R_PANTR
Sequence: MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQKDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGKQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHETYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNETFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
What is the function of this protein?
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
What are the official names of this protein?
Complement C1r subcomponent, Complement component 1 subcomponent r.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: AMPP2_ASPOR
Sequence: MRVSEPSDVVIRSDDTCHIHLTWSGSECDKYPAKQHARKVAMKLGVSSGLIYLVGQPTVNWGDSDQPQPFRQRRYFYYLSGIDEPDCYLTYDIQADLLTLYVPDFDLRRAVWMGPTLTIEEAHKQSDVDRVNFFAALQHDLEWWTTKNKGTRPIYVLHDSQQPLIPSKRLWLDNERLLPAMNAARVIKDEYELRMIRQANYISGLAHRKILEDIHRMSTEAEIESSFLATCVSHGAKNQSYAIIAGSGENAAVLHYVKNNEPLDGRQLVCLDAGAEWRCYASDVTRTIPLWTDWPSERARNIYRVVEEMQEECIRRIRKGVRFRDLQLLAHDIAIKGLQKLDILTNDCTSAIYESGASAVFFPHGLGHHVGLEVHDVSKRPITALDGNQANWGNHNFVPLLTDSSWSVPLLDEGMVVTIEPGIYFNRLALLNAQNQPLAKYINFDEAEKYIPIGGVRIEDDILVTAKGYENLTTAPKGEEMLEIIRRGIDNS
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase AO090005001240, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: RUVB_TOLAT
Sequence: MIEADRLIAPAAITEEEQLDRAIRPKMLSDYRGQDQVRSQMEIFIEAARRRSEALDHVLIFGPPGLGKTTLANIVANEMGVNIKTTSGPVLEKAGDLAALLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKLELPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYKVEDLAHIVGRSADVLGLSLDQQGAFEIAKRARGTPRIANRLLRRVRDFAEIRSDGHISDQIAAQALDMLDVDNAGFDYMDRKLLLAIIDKFLGGPVGVDNLAAAIGEEKETIEDVLEPYLIQQGFLQRTPRGRIATPRAYLHFGLTTPERQG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: Y2876_MYCBO
Sequence: MTEALRRVWAKDLDARALYELLKLRVEVFVVEQACPYPELDGRDLLAETRHFWLETPDGEVTCTLRLMEEHAGGEKVFRIGRLCTKRDARGQGHSNRLLCAALAEVGDYPCRIDAQAYLTAMYAQHGFVRDGDEFLDDGIPHVPMLRPGSGQVERP
What are the official names of this protein?
UPF0039 protein Mb2876c.
What is the protein family that this protein belongs to?
Belongs to the UPF0039 (ElaA) family.
Protein: PUR7_GEOMG
Sequence: MANLVLKTDFPDLKLVARGKVRDIYDLGEALLIVTTDRISAFDVIMNEGIPDKGYVLTQISAFWFRQMEDIIPNHIISTEVKDFPAECQKYAADLEGRSMLVKKANPLPAECIVRGYISGSGWKDYKATGSICGIKLPAGLVESDKLEEPIFTPSTKAELGTHDENISFDRMVEMMGKELAGKVRDVTIAIYKRARDIADAKGIIIADTKFEYGIYNGELIIIDECMTPDSSRFWPKDSYKPGGAQPSFDKQFLRDYLETLDWNKTAPAPPLPAEIVKKTGEKYMEALVRLTGKGK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: MNMC_PARP8
Sequence: MTDPLVPAVLAFRDNGTPYSPLYDDIYHSAVGGLAQADYVFLKGNDLPSRWQKRRLFTVLETGFGMGINFLVTWAAWRADPDRCERLHFVSTEKHPFSREDLIAATNSSVADASIAALAEQLANAWPTLVPGTHRLEFEEGRVILTLVFGDAVQTLPTLWLRADAFYLDGFSPDRNPDLWTPAVFKSLARLAGDEATFATYTSSGDVKRSLQQAGFEYRKVDGFGWKRAMLVGRFAPRYRVRRHEPPLPLAVGERHAIVIGTGLAGCAAIERLTARGWRVTSLERHADVARDASGNPAGVFHPMMSRDDSVGSRITRAGFLYALRQWSALEHRGHRPLRGPEGLLQIAADEEEALAMAHTFASFAWPREYVVSVTRDDAERIANMRVARGGWLFPHGGWIDPASLCAAQCEAAGGLLERRFNVAAARVERLENQWIVFDENGAAVVSAPVVIFANAHEAARVAGLHYASTRSVRGQLTLLPADATNAPRLPVIGEGYALPLLDGVTLTGATYDIDDPDTRLRDGAHIENIERVAQMLPDMRDAFNVHAPSSLTGRVAFRCVTSDRLPMIGAFADEAAAIRDAGKLCGAWPLDLPRADGLYGAFAFGSRGLVWASLGAELMASQIEGEPWPIERDLAEALDPARFLLRALRQGTAS
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUS3_USTMA
Sequence: MSEADAATSAMDSAAEAAEQVWKHPVYGATDKYTPGIAPIKAEYILPKPASGSVAVVEVNDDASERLTKRALATTGDSASVTTNTSDEAPKKLKGAARKRARREEAAALAAAHRAEKKCKAGQQTQHAKKGGQNKARQFSSLKDAHGHCHGFLSRGVQGCKFAQCAQACRFSHDLVSYLEKKERDLFLPAVPHKQLDAMSHTQKMQWLQDSYSLTLLPASNTSTTASASTQQLEAQQQAQGEMTTFVRASSSAAVPPRSDLPASSDPAHASLDWSTTCPIFAVKGFCTMGWKCRFLGSHVRLVGASSLGDPLNPTGFASSGLELVRDQARMDEWRARTRAFELSHAKQSASDADQDELNFGTSDGMKAMRKRNFPLPKTKAVLKFLETETKQLADVDPHGSIAGKGPIPTSVVEEAVAVSAGANGCNGHSTAPASAAAAEAEAEDDLEELENAMRNRGLHARVAQAATTNGSIDLARIRPSEKRRLNWRGELYLAPLTTTGNLPFRRICTGYGSDIHCGEMGLAESFLHGNAAEWSLVRRHESERIFGTQLCGGKPDLLVPVAEALKAEVGDGLDFVDINCGCPIDLVFNKGAGSALLDHPTKLSKIVRGMNAVLGDTPLTIKLRTGTGAKQTTHKIFAKAQTEWRVAAATLHGRSRKQRYKNDADWGYIATCANTLRESVSEWNESSRFADEPEMVPIPVYGNGDVYSWQDYYERIERTHVDGEMIARGALIKPWLFTEIKERRDWDISSRERLDMMRKFAEYGLTHWGSDTHGVNTTRRFMCEMMSFTHRYVPTGLLEFLPSRLNDRPPLFRGRDELETLLASSNAQDWVKLTEMFLGKPPQEWSFTPKHKSSSYSTDDAAEQQG
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.  Specifically modifies U47 in cytoplasmic tRNAs (By similarity).  Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
What are the official names of this protein?
tRNA-dihydrouridine(47) synthase [NAD(P)(+)], mRNA-dihydrouridine synthase DUS3, tRNA-dihydrouridine synthase 3.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PRMC_ALIF1
Sequence: MSLSIEALLKRSIQSLTLEGSDSPQVDAAVLLCHVLDKPRSYLLTWPEKIVSDEELGNFNALLERRLAGEPIAYIVGYREFWSLPLKVSPTTLIPRPDTERLVEVALDHLTPNAQSILDLGTGTGAIALAIASEMPTLNVIGVDYQDDAVELAKGNAKINHINNVEFRQGSWFEPISLSDKFDIIVSNPPYIDGNDPHLSEGDVRFEPQTALVAEQNGFSDLIHIMQHGREYLLNGGWLMMEHGFEQGEQLRHFFEEHGYINVKTEQDYAGNDRVTLGQWVVDN
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: EIF3I_SCLS1
Sequence: MRPILLQGHERALTQIRYNKDGDIIFSTAKDQHICAWYAHNGERLGTYHGHQGAIWTVDVDPTTTIIASGAADNTVRLWDVKTGKCLKTWDFNTAVKRVEFNEDATQLLAVTEQRMGFLGTIVVLDINLDVNGPQSDDRALTITCAESKATVAGWSYMSKYIIAGHEDGSVSQYDSKTGELLFNTQVHEPDLQVTDLQWSPDRTYFITASKDKTAKLVNARDLEVMKTYVTDTPLNSASITPKKDFVILGGGQAAMDVTTTSARQGKFEARFYHKIFEEEIGRVRGHFGPLNTVAVDPNGKGYASGGEDGYVRVHQFDKGYFDFTYEVERQVRQQ
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit I, eIF3i, Eukaryotic translation initiation factor 3 39 kDa subunit homolog, eIF-3 39 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit I family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCDH_DICDI
Sequence: MLSNLSKSLLSKGKFINKNNLLKNKRSFGTIVPGDKFEWNDPLSLESLLTEEEVMIRDQVNKFCQDELMPRIQMAYRDEKFDREIMREYGKMGMLGATIPAYGGVSHVAYGLMANAVEKVDSGYRSAMSVQSSLVMHPINTFGTDAQKSKYLDGLASGDLVGCFGLTEPNAGSDPAGMQTRAVKNSAGNYVLNGTKTWITNSPIADVFVVWAKVENGDIRGFVLEKGMKGLSAPKIEGKLSLRASITGMIVMEDVEVPPTAMFPEVKGLRGPFSCLNKARYGIGWGSLGAAEFCYSTARQYGLDRKQFGKPLAANQLYQKKLADMATEISLGLQACYQVGRLIDAGKATPERISLIKRNSCGKSLDIARQSRDMLGGNGIADEYHVIRHAANLETVNTYEGTHDIHALILGRAITGIPSF
What are the official names of this protein?
Glutaryl-CoA dehydrogenase, mitochondrial, GCD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: T23OL_XANC8
Sequence: MTARDFLEFRERLAPASGFQSAQLREIEILLGLEDTQRISIGNGCSYRDALKLPGGAPSSSAQRVEARAADGPSFKHCLYDWLSRVPIDGSNAPADITRFLEAYLASLRAENDRRLKLASSGLAAAEIEQLRARYAAEDAGAQAFLLAEDDPQASDAERETRRAGRAAMLFIESYRELPQLAWPHALLESVLELEQAMLIWRQRHARMVERFIGRRIGTGGSSGVDYLDQTARYRIFTELWTVRSLLLRKAAVPQIRSSAGYGFVMEGFA
What are the official names of this protein?
Tryptophan 2,3-dioxygenase-like protein, TO-like protein, Tryptamin 2,3-dioxygenase-like protein, TRPO-like protein, Tryptophan oxygenase-like protein, Tryptophan pyrrolase-like protein, Tryptophanase-like protein.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: ISPH_CAMHC
Sequence: MKIELAKKYGFCFGVKRAIKIAENTENSATIGELIHNNEEIDRLHKKFGVKTLNDISEITDEKRLIIRTHGITKDDLDVLKSKNKELIDATCPFVKKPQQIVEKMSSEGYDIVIFGDKNHPEVKGVKSYAKGKVFVVLDVSELKNLKISNKVALVSQTTKRIENFTKIAEFLMTTTKELRIFNTICNATFQNQEAAAKLAKKADVMIIIGGKNSSNTKQLLLISQNFCKNSYLIENENELKKEWFLNKEICGITAGASTPEWIIKKVVKKINTMC
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: GCSH_STRM5
Sequence: MSEIPGDLKFLKSHEWARVEGNGRVTVGISDHAQGLLGDLVYVELPEVGATAKANEQIAVVESVKAASDVYSPVSGTIVEVNSALSDKPETINEDAYGDGWMYVVELSNAEELNELLDPDAYAEALEDEDH
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RL3_BRUAB
Sequence: MRSGVIAQKLGMTRVYNDAGEHVPVTVLRMENCHVVAQRTVEKNGYTAVQLGVGMAKVKNTSKAMRGHFAKAEVEPKAKLAEFRVSPDNLLEVGVEITAEHFVAGQKVDVTGTSIGKGFAGVMKRHNFGGHRASHGNSITHRSHGSTGQRQDPGKVFKGKKMAGHMGQTRVTTQNIEVVSTDSDRGLILVRGAVPGSKGAWILVRDAVKASLPENAPKPAGLRAGAKAEAAATEGGE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: IL15_PIG
Sequence: MRILKPCLRSTCIQCYLCLLLNSHFLTEDGIHVFILGCISAGLPKTEATWQHVISDLKKIEDLIRSIHMDATLYTESDAHPNCKVTAMKCFLLELRVILQESRNSDISDTVENLIILANSSLSSIEYKTESGCKECEELEEKNINEFLKSFIHIVQMFINPS
What is the function of this protein?
Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.  Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines.  In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection.  Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits.  Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity).  In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).
What are the official names of this protein?
Interleukin-15, IL-15.
What is the protein family that this protein belongs to?
Belongs to the IL-15/IL-21 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CET1_YEAST
Sequence: MSYTDNPPQTKRALSLDDLVNHDENEKVKLQKLSEAANGSRPFAENLESDINQTETGQAAPIDNYKESTGHGSHSQKPKSRKSSNDDEETDTDDEMGASGEINFDSEMDFDYDKQHRNLLSNGSPPMNDGSDANAKLEKPSDDSIHQNSKSDEEQRIPKQGNEGNIASNYITQVPLQKQKQTEKKIAGNAVGSVVKKEEEANAAVDNIFEEKATLQSKKNNIKRDLEVLNEISASSKPSKYRNVPIWAQKWKPTIKALQSINVKDLKIDPSFLNIIPDDDLTKSVQDWVYATIYSIAPELRSFIELEMKFGVIIDAKGPDRVNPPVSSQCVFTELDAHLTPNIDASLFKELSKYIRGISEVTENTGKFSIIESQTRDSVYRVGLSTQRPRFLRMSTDIKTGRVGQFIEKRHVAQLLLYSPKDSYDVKISLNLELPVPDNDPPEKYKSQSPISERTKDRVSYIHNDSCTRIDITKVENHNQNSKSRQSETTHEVELEINTPALLNAFDNITNDSKEYASLIRTFLNNGTIIRRKLSSLSYEIFEGSKKVM
What is the function of this protein?
First step of mRNA capping.  Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
What are the official names of this protein?
mRNA-capping enzyme subunit beta, mRNA 5'-phosphatase, mRNA 5'-triphosphate monophosphatase.
What is the protein family that this protein belongs to?
Belongs to the fungal TPase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LIPM_MOUSE
Sequence: MSEILSRVWTVSHRVEIWLLILVAYLLQRNVNSGHLPTKAADPEAFMNVSEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEGSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQKKVYYVGYSQGTTMGFIAFSTMPELAHKIKMYFALAPIATVKYARSPGTKFLLLPDMMIKVLFGRQEFLYQTRFFRQLFIYLCGQMILDQICSNIILLLGGFNTNNMNMSRANVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWGSETKNQEKCNQPTPIRYKVRDMMVPTAMWTGGQDWLSNPDDVKTLLSEVTNLIYHKNIPEWAHVDFIWGLDAPQRVYNEIIHLMKQEPNLPQGTCRVKL
What is the function of this protein?
Plays a highly specific role in the last step of keratinocyte differentiation.  May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity).
What are the official names of this protein?
Lipase member M, Lipase-like abhydrolase domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3135_HAEIE
Sequence: MSDIAITISLLALVAVIGLWIGHWKIRGVGLGIGGVLFGGIIVAHFTDQYGLKLDAHTLHFVQEFGLILFVYTIGIQVGPGFFSSLRKSGLKLNAFAILIIVLGSIAVVLVHKIADVPLDIALGIYSGAVTNTPALGAGQQILAELGVPQTTVTMGVSYAMAYPFGICGILLAMWLIRLFFNVKVDDEAARFNAESSQDKESLHNISLKVTNQNLDGLTLIQIPGFSDEEVVCSRLKRDDMEIVPKASTEIRTNDILQLVGDDNSLAKMRLIIGYEVDAPTVAYSGEIRSERVVVTNEKVLGKKIRALGIHQKYGVVISRLNRAGIELVPTGNTTLQFGDVLHMVGRSDVLNQAISVIGNAQQKLLQVQMLPVFIGIGLGVLVGSIPFYIPGFPVALKLGLAGGPLVVVLILARIGTIGKLYWFMPPSANLALREIGIVLFLAVVGLKSGGSFFDTLVNGSGLEWMGYGIFITFVPLIIAGTIARLYGKLNYLTICGLLAGSMTDPPALAFANEIKEDNGAAALSYATVYPLVMFLRIMSPQLLAVLLWAA
What are the official names of this protein?
Putative transport protein CGSHiEE_03135.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NRAM_I00A0
Sequence: MNPNQKIITIGSICMVIGIVSLMLQIGNIISIWVSHSIQTGNQHQAEPCNQSIITYENNTWVNQTYVNISNTNFLTEKAVASVTLAGNSSLCPISGWAVYSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRTLMSCPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKIEKGKVVKSVELNAPNYHYEECSCYPDAGEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSPNGAYGIKGFSFKYGNGVWIGRTKSTNSRSGFEMIWDPNGWTGTDSNFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.