PharMolix/UniProtQA huggingface dataset:
Protein: JMJ21_ARATH
Sequence: MTTLGQRDRRPDALGSLSVLPDETICVLLEYLAPRDIAHLACVSSVMYILCNEEPLWMSLCLRRAKGPLEYKGSWKKTTLHLEGVTQENDAYRKCFHFDGFMSLYLYKRFYRCNTSLDGFSFDNGNVERRRNISLDEFSKEYDAKKPVLLSGLADSWPASNTWTIDQLSEKYGEVPFRISQRSPNKISMKFKDYIAYMKTQRDEDPLYVFDDKFGEAAPELLKDYSVPHLFQEDWFEILDKESRPPYRWLIVGPERSGASWHVDPALTSAWNTLLCGRKRWALYPPGKVPLGVTVHVNEDDGDVSIDTPSSLQWWLDYYPLLADEDKPIECTLLPGETIYVPSGWWHCILNLEPTVAVTQNFVNKENFGFVCLDMAPGYHHKGVCRAGLLALDDENSEDLEEETHDEEDNTLSYSDLTRKEKRTRMNGGGETENREEDVNGVSKRYNMWKNGFSYDIDFLASFLDKERDHYNFPWSMGNSVGQREMRAWLSKLWVLKPEMRELIWKGACIALNAEKWLRCLEEVCTFHNLPLVTEDEKLPVGTGSNPVYLLSDYAIKLFVEGGLEQSMYGLGTELEFYDILGRADSPLKTHIPEVLASGILFFEKGSYKVVPWDGKRIPDIISSSSFDFDASMLNSEFPFGIWNKTLREHKNQGKPAPDSFGSLSSHVWPYIITKRCKGKIFAQLRDDLTWNDAQNLAFFLGQQLRNLHLLPYPPVTRPELLNVNAVHEELNIPAEWKVFVDALCQKKKDVTSRLENWGNPIPRALMTKIDEYIPDDFFVDLLHVFKETNGGDEIKPCTWIHSDVMDDNIHMEPYADDSVDGQHNSWRPSHILDFSDLTIGDPICDLIPIYLDVFRGDADLLKKLLENYGLPLIRSRSSENGTTKTADSTRKKVLSPSYRTMCYCILHEENVLGSIFSIWDELRTAESWEQVEQTVWSLLNTY
What is the function of this protein?
May function as histone H3 lysine demethylase and be involved in regulation of gene expression.
What are the official names of this protein?
Lysine-specific demethylase JMJ21, F-box protein JMJ21, Jumonji domain-containing protein 21, AtJMJ21, Protein JUMONJI 21, Lysine-specific histone demethylase JMJ21, [histone H3]-trimethyl-L-lysine monodemethylase JMJ21.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECA_BARQU
Sequence: MDKTKALDAALSQIERSFGKGSIMRLGQKEQVVEIETIPTGSLSLDIALGVGGLPKGRIVEIYGPESSGKTTLALHAIAEAQKNGGVCAFIDAEHALDPIYARKLGVDLENLFISQPDTGEQALEITETLVRSGAVDVLVVDSVAALTPRAEIDGEMGDALPGLQARLMSKALRKLTASIFRSNCMVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRVGSIKDRDMIVGNQTRVKVVKNKLAPPFKQVEFDIIYGEGISKLGELIDLGVKVGIVEKSGSWFSYNSQRLGQGRENAKQFLREHAEIATEIETALRQNAGLIAIELLENAGSENTESNEAI
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHX5_ARATH
Sequence: MESRNEAYEGAYNATFWGDFSYHGYGFSEDGSKFCEQIPILVNSFGVWEKLDLPIRGMKIWDYSLPHLESVIVLVLCLWQFFYLSLKKIGLPVPKITSMMIAGAALSQTNLLPNDWTIQHILFPDDTRPKVPETLGGFAFVFYWFIEGVKMDVGMVRKTGTKVIVTGIATVILPIIAANMVFGKLRETGGKYLTGMEYRTILFMQSISAFTGISRLLRDLRINHSEFGRIVISTAMVADGTGFGVNLFALVAWMDWRVSALQGVGIIGYVIFMVWVVRPAMFWVIKRTPQERPVKECFIYIILILAFGGYYFLKEIHMFPAVGPFLLGLCVPHGPPLGSQLVEKFESFNTGILLPLFLFFSMLQIDGPWLANQIGQLRHFDGQLYEALTIIIVVFVAKIIFSMIPALLAKMPLTDSFVMALILSNKGIVELCYFLYGVESNVLHVKSFTIMATMILVSSTISPVLIHYLYDSSKRFISFQKRNLMSLKLGSELKFLVCIHKADHISGMINLLAQSFPLHESTISCYVIHLVELVGLDNPVFISHQMQKAEPGNRSYSNNVLIAFDNFKHYWKSISLELFTCISNPRYMHQEIYSLALDKQASFLMLPFHIIWSLDQTTVVSDDVMRRNANLNVLRQAPCSVGIFVHRQKLLSAQKSSPSFEVCAIFVGGKDDREALALGRQMMRNPNVNLTVLKLIPAKMDGMTTGWDQMLDSAEVKEVLRNNNNTVGQHSFVEYVEETVNDGSDTSTLLLSIANSFDLFVVGRSAGVGTDVVSALSEWTEFDELGVIGDLLVSQDFPRRGSVLVVQQQQNVACR
What is the function of this protein?
May operate as a cation/H(+) antiporter.
What are the official names of this protein?
Cation/H(+) antiporter 5, Protein CATION/H+ EXCHANGER 5, AtCHX5.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y571_MYCPN
Sequence: MKIIYQEQPNECGICVLGMLANELHEDKYAHDELLEQINLPASGLSFFELETYGKKFGLEIASYQLTLEELKQLEGKYFIVHFPKHFVVVHKKQDNLWEVFDPAKGKYLLNDEELKKQWTGYAATVQKSFKEIPPINKRNFFKHFFDLNLIIFYVFIELIIIGISTLLATASKTMIANTVDFGTSVNIVVFVVFFLVLKGLYLLLYALLQMVRNVLFWKQYRGYLGWIMQTLQTKSFVYFSNKSPNQLTERQFYLKEVLSFFNVHIPNLIISCTVALIIGTLIGINQMEFLWIAIVQIVVNCAIFLYDFFFTKRITKQAIPQMELQNKVSLQLDGNLRDEQNGKRFNYLMMQLRKALIKNQNISNQKEVNHLASDGVKSFAQQVFDFLILALGIIGIIEQRYTLAFLFYIFSIQALFSAYATRIIQFGAAVNLYQFCKDKLVTLFEDKVNDCNFKVSWKCPKVINLNNCSITLNQNLDLANLNLNLTNGMVISGENGSGKSTLLKILTGRGLSYQGQIKLDELDLKDFSASQLFHNVYYLTGQLTAYNDITDFGYSEALLNCKNPQVYQLLADTGIHNQIKLSSGQKQILQLFLLQNLKDKVILLDETLNAIATELKPRVYQLLIKPLTYNNFVLMVEHDLRFVNSEQDLINLSPYLQQT
What are the official names of this protein?
Putative ABC transporter ATP-binding MG390 homolog.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2987_NOSS1
Sequence: MTVAKKHWFQIAFQLRGSVIGAIYKRVICCALFGVLVTLLYQLKIPVSQPILGSVIPSIVLGLLLVFRTNTAYDRFWEGRKAWGSIVNNTRNLARQIWVSVEEVSLKDREAKISVLNLLVAFAVATKLHLRGEPINSELEDLISTSRYFKLKSMNNPPLEVAFWIGDYLQQQYTCKCLNSYQLTSIQELLNNLVDNLGSCERILRTPMPLAYSIHLKQLLLLYCFLLPFQMVESLGWWTGLVVGLVSFTLFGIEAIGLEIENPFGYDPNDLPLDAICNTMKRNIDDLTSLSPNVRSHDLGETSNVTI
What are the official names of this protein?
Voltage-dependent anion channel-forming protein alr2987.
What is the protein family that this protein belongs to?
Belongs to the anion channel-forming bestrophin (TC 1.A.46) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YIDD_AERS4
Sequence: MAHSVTPLQWVAVKLIRLYQLIISPLLGQRCRFTPTCSQFAIEAIRLHGFIKGVWLASKRLLKCHPLSEGGYDPVPQPKRRN
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HLDD_BORA1
Sequence: MIVVTGAAGFIGSNLVRGLNRRGIYDIIAIDDLTEGDKFRNLVDCRIADYMHHEDARALLKAGQFPRVRAVLHQGACSDTTERNGQYMMDNNYRVTLEWFEYCQANRVPLIYASSAAVYGASTVYVEDPANEGPLNVYGYSKLLFDQVLRTRMDKLTAQVVGLRYFNVYGPHEQHKGRMASVAFHNMNQFLAEGHVRLFSGWDGYADGGQSRDFISVEDVVDVNLHFLDHPGTSGIFNCGTGRAQPFNDVAAAVVNTLRAEQGEAPLSLDELVSQGLIRYIPFPDDLKGRYQSFTQANVDALRAAGYTAVMRDVQTGVSEYVRYWRSRKSLA
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: ZSWM1_HUMAN
Sequence: MLERLKAPWSAALQRKYFDLGIWTAPISPMALTMLNGLLIKDSSPPMLLHQVNKTAQLDTFNYQSCFMQSVFDHFPEILFIHRTYNPRGKVLYTFLVDGPRVQLEGHLARAVYFAIPAKEDTEGLAQMFQVFKKFNPAWERVCTILVDPHFLPLPILAMEFPTAEVLLSAFHICKFLQAKFYQLSLERPVERLLLTSLQSTMCSATAGNLRKLYTLLSNCIPPAKLPELHSHWLLNDRIWLAHRWRSRAESSHYFQSLEVTTHILSQFFGTTPSEKQGMASLFRYMQQNSADKANFNQGLCAQNNHAPSDTIPESPKLEQLVESHIQHSLNAICTGPAAQLCLGELAVVQKSTHLIGSGSEKMNIQILEDTHKVQPQPPASCSCYFNQAFHLPCRHILAMLSARRQVLQPDMLPAQWTAGCATSLDSILGSKWSETLDKHLAVTHLTEEVGQLLQHCTKEEFERRYSTLRELADSWIGPYEQVQL
What are the official names of this protein?
Zinc finger SWIM domain-containing protein 1.
Protein: UVRC_ACTP2
Sequence: MFDAKAFLADVPHLPGVYRMYDAKNTIIYVGKAKDLKKRLSSYFRSQLASKKTEALVANIHHIETTITHSETEALLLEHNYIKENQPKYNVLLRDDKSYPYILLTKHQHPRITSFRGSKKVAGEYFGPYPNAGAVRETLNLLQKLFPIRQCEDSYYKNRSRPCLQYQIGRCLAPCVEGYYSQAEYDNQVNLVRLFLQGKDGQVVEHLVQKMENAAQELDFEAAARFRDQIQSVRAVQEKQFVSNERLDDLDIISIAYQHGIACVHILFVRHGKVLGNRSYFPKVPNNTDLSELADTFVGQFYLQMNQHRTIPNQIIIDQSLSEVTALANVLSEQAGHKVSIADKNIRGDKSRYLALAKTNAEAALTLQLKQDTHIRQRYDSLKALLNLAEIKRMECFDISHTMGNQTVASCVVFDKNGPLKSDYRRFNIEGITGGDDYAAMEQALLKLYDRNLEEEKIPDIIFIDGGKGQLNRALETFTSLNVSWDKRKPLLVGVAKGVERKAGLETLLISKWDKEIHLPPDSPALHLIQHIRDESHNHAITGHRKKRQKAFTESGLESIAGVGAKRRQALLKYLGGMQGVKAATLEEIQSVPGISKQLAEVIFDTLQHS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_PYRIL
Sequence: MAKYVIGSAWPYVQTVPHLGNLIGSVLSADVYARYLRFRGHDVVFVSGSDMHGTPIEVEAIQLGVDPEEYAKKMHQIVAELFKRWDISFDLYTHTHSDTHIKFVQNFFLKIYNNGYIFTKEEEVPYCPRDKIYLPDRFIIGKCPYCGYERARGDQCENCGRLLDPKQLIEPRCAICGSRPEWRITKHWYLDLRKLEDRIRKYVEENPHLPPNAKEMSLGMLKEGLKPRAITRDNKWGIPAPFPGAEGKTIYVWFEAVLGYISAVVELFREDAGKWERYWKDPETKIVFFVGKDNIPFHVIILPALLLANGEGYTLPTTTASTEYLLYEGDKFSKSRRWGIWIDEALQLMPPDYWRFILIYIRPENRDTSFTWALALEIINKIMNDDVGNYINRVLTFIKNRMGGVVPPPGAPTREDEEFINRVIQLFKKAEKHYDAIELKDALHTVVEIAREGNRYLNARAPWELLRRDIEVANAVMYRAYWSLKTIAAGLTPVTPRSAAELWKMLGISQPSWDEAYKPPTPGTPLGDVRPLFRKFTEEEVKDMLKKLEELRSQRASKKYPWEQVLL
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDGC_ECO81
Sequence: MLWFKNLMVYRLSREISLRAEEMEKQLASMAFTPCGSQDMAKMGWVPPMGSHSDALTHVANGQIVICARKEEKILPSPVIKQALEAKIAKLEAEQARKLKKTEKDSLKDEVLHSLLPRAFSRFSQTMMWIDTVNGLIMVDCASAKKAEDTLALLRKSLGSLPVVPLSMENPIELTLTEWVRSGSTAQGFQLLDEAELKSLLEDGGVIRAKKQDLTSEEITNHIEAGKVVTKLALDWQQRIQFVMCDDGSLKRLKFCDELRDQNEDIDREDFAQRFDADFILMTGELAALIQNLIEGLGGEAQR
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: IF2_YERE8
Sequence: MTDVTVKSLADEIQTPVDRLVQQFADAGIKKSEVDSVTQQEKETLLAHLNREHGSAPNKLTLQRKTRSTLNIPSTGGKSKSVQIEVRKKRTYVNTPEAEQAKAEEQAQREAEEQAQREAEAAAQKIAEEKAKRAAEEQAKREAAEKAKRQAAEKEKVTNQQTDEKTKPAQTDKARREAEAAELKRSVEEETRRKVEEDAKRVAEEARKMAAENEGKWPEPVAEQTESADYHVTTSQHARAAEDENDAKVEGDRRSRTRGGKATKQKKGNKLSESKADREEARAVGRKGKRKPSTLQQSFNKPVVAVNRDVVIGETVTVAELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEALMSDRDTGAEAAAEHRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAANVPVVVAVNKIDKPAADPNRVKTELIQHGIISEDFGGDVPFIEVSAKVGTGIDDLLQAILLQAEVMELKAVRTGMASGVVIESFLDKGRGPVATVLVQQGTLNKGDIVLCGFEYGRVRAMRDELGRDITSAGPSIPVEILGLSSVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVSELNIVIKSDVQGSCEAICDSLEKLSTDEVKVRIVGSGVGGITETDATLAAASGAIILGFNVRADASARRVVETEGLDLRYYSVIYSLIDEVKQAMSGMLAPEYKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVIKRNNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIKRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_YERPA
Sequence: MLKREMNIADYDADLWRAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKALFGADYANVQPHSGSQANVAVYSALLKPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDESGQIDYEDLARQAEIHKPKMIIGGFSAYSGIVDWAKMREIADSIDAWFFVDMAHVAGLVAAGVYPNPVPHAHIVTTTTHKTLAGPRGGLILAKGGDEDLYKKLNSSVFPGNQGGPLMHVIAGKAVALKEAMEPEFKIYQQQVAKNAKAMVAVFLERGYKVVSGGTDNHLFLLDLVDKDITGKDADAALGRANITVNKNSVPNDPKSPFVTSGVRIGSPAITRRGFKEAESRELAGWMCDVLDNINDEATIERVKQKVLAICARLPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT4_BOMMO
Sequence: MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
What are the official names of this protein?
Actin, cytoplasmic A4.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL4_XYLF2
Sequence: MDLTIVGSDNTLPVSDVVFGREFSEALVHQVVVAYRNTARSGTKAQKSRSQVSGTTKKSKKQKGGGARHGALTAPIFVGGGVAFAAKPRSFSQKVNRKQYRSAICSIFSELNRQGRLKVVDAFDVEVSKTRVFAEKIKSLEVVGSSLLIVSDEISECLSLSSRNLPCVDVRSVQALDPVALVGSDVVVLTVGAVKKIEEWLV
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NRAM1_MOUSE
Sequence: MISDKSPPRLSRPSYGSISSLPGPAPQPAPCRETYLSEKIPIPSADQGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAISFNLLSAGRIPLWDGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVAHPSQGALLKGLVLPTCPGCGQPELLQAVGIVGAIIMPHNIYLHSALVKSREVDRTRRVDVREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQQTNEEAFNICANSSLQNYAKIFPRDNNTVSVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLVAVFRDLKDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPAVMQEFANGRMSKAITSCIMALVCAINLYFVISYLPSLPHPAYFGLVALFAIGYLGLTAYLAWTCCIAHGATFLTHSSHKHFLYGLPNEEQGGVQGSG
What is the function of this protein?
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens.  Macrophage-specific membrane transport function.  Controls natural resistance to infection with intracellular parasites.  Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
What are the official names of this protein?
Natural resistance-associated macrophage protein 1, NRAMP 1, Solute carrier family 11 member 1.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BAP1_BOVIN
Sequence: MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPLALETSRAPVASESTHTDGVEEVAGSCPQAPTHSPPSKPKLVVKPPGSNINGVPPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDEEEDDAQSTSSAIRYKRKGPGKPGPLSSSGDGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTESGKGSSPSIRPSQGSQGSGSPEEKEVVEAVDSREKPGLVRPSESLNGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
What is the function of this protein?
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1.  Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).  Does not deubiquitinate monoubiquitinated histone H2B.  Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains.  Deubiquitination of HCFC1 does not lead to increase stability of HCFC1.  Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination.  It however does not mediate deubiquitination of BRCA1 and BARD1.  Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration.  Acts as a tumor suppressor.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase BAP1, BRCA1-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C12 family. BAP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O.
Protein: RS17_PSESM
Sequence: MAEAEKTVRTLTGRVVSDKMDKTITVLIERRVKHPIYGKYVKRSTKLHAHDETNQCHIGDKVTIRETRPVAKTKSWALVDILERAVEV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RISB_HAEI8
Sequence: MKVLEGSVAAPNAKVAVAIARFNSFINESLLEGAIDALKRIGQVKDENITIVRTPGAYELPLVARRLAESKKFDAIVALGTVIRGGTAHFEYVAGEASSGLGKVAMDAEIPVAFGVLTTENIEQAIERAGTKAGNKGAEAALTALEMVNLIQQIDAA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RNAS1_AEPME
Sequence: KESAAAKFERQHMDSSTSSASSSNYCNQMMKSRNLTQSRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQAKKHIIVACEGNPYVPVHFDASV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic, RNase 1, RNase A.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: RAB6B_MOUSE
Sequence: MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNLNSFQQTSKWIDDVRTERGSDVIIMLVGNKTDLADKRQITIEEGEQRAKELSVMFIETSAKTGYNVKQLFRRVASALPGMENVQEKSKEGMIDIKLDKPQEPPASEGGCSC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between active GTP-bound and inactive GDP-bound states.  In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.  Recruits VPS13B to the Golgi membrane.  Regulates the compacted morphology of the Golgi.  Seems to have a role in retrograde membrane traffic at the level of the Golgi complex.  May function in retrograde transport in neuronal cells.  Plays a role in neuron projection development.
What are the official names of this protein?
Ras-related protein Rab-6B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules.
Protein: H2B1_MAIZE
Sequence: MAPKAEKKPAAKKPAEEEPATEKVEKAPAGKKPKAEKRLPAGKSKEGGEGKKGKKKAKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAAESAKLARYNKKPTITSREIQTSVRLVLPGELAKHAVSEGTKAVTKFTSS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.1.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PRTT_ASPNC
Sequence: MTRTVDEIKYETPSSWEHKSLDVAEDGRRLAPHSDTARPKGRIRRSMTACHTCRKLKTRCDLDPRGHACRRCLSLRIDCKLPETTDRFQDSAAMWPDATSAIPSIEERLTSLERCMREMTGMMRQMLDHSPGFANASVPHLTKSIITDENASMEGSPSSPFLPKPVRLIQDLQSDFFGEAETSPVDSPLSSDGNAKGAIDSKLSLKLLQTFVDHFGACVSIYNLSDIHNDMKAPDSLLYNTACLLASRYVPGIPTSTVHAIYLQVRHAVVNILWEKPPLKYETLQALALLCLWPATAQKEPPMDSWLLSGISINHAIIALDFLNYAPSEVMVDNETAAQLRLWNTYCLTQLHFAVGNARPFHIQQRYLDHCPRILEHPAATLEDARVVAEIQLYLMTLRLQSNSSRMRLADLDYEEIERWKREWAHLFSGESSTLELSLWFCQTLLHRTAMRLQPRSDRLASEVLQTSRLIISRFLQIRYSTALSLVDQVYFIVGYAALNLCDFNLMDPLIEQVQMFLLHLSPNEDHIAYRFSCMVAEFKRRCGSAECNDPSSTVKGSPLSSYGDSRKMSMGQAPFMPPLMDGMIEGYGFEQLMPEVMPSSFPDGILNGMPVTGLAAYRSATL
What is the function of this protein?
Transcription factor required for protein utilization and degradation.  Regulates transcription of major secreted proteases.
What are the official names of this protein?
Transcriptional activator of proteases prtT, Zn(2)-C6 zinc finger-containing protein prtT.
What is the protein family that this protein belongs to?
Belongs to the prtT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DCUP_BRUME
Sequence: MNLKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHALGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGFPKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGITPQAPIENVQRMIDRVRGGKS
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.