PharMolix/UniProtQA huggingface dataset:
Protein: SLAB_BOTJA
Sequence: MGRFIFVSFGLLVVFLSLSGTAADCPPDWSSYEGSCYRVFEQKMNWEDAEKFCTQQQTGGHLVSFQSSEEADFVVSLTSPILRDSFVWTGLSDVWKECSFEWSDGSDLSYKDNYQFVFSEYECVASKTKNNKWRIIPCTKLEYFVCEFQA
What is the function of this protein?
This potent antithrombotic agent acts in a calcium-independent manner.  Exerts its anticoagulant effect by two distinct mechanisms.  It binds to activated thrombin through exosite 1, blocking fibrinogen clotting, platelet activation, factor V activation and other effects, and it interacts with prothrombin (F2), decreasing its proteolytic activation -especially in the presence of factor Va.  In vivo, intravenous injection before thrombosis induction causes a significant decrease in thrombus weight.  Furthermore, BJC shows a prolonged effect by remaining in the plasma bound to prothrombin for at least 12 hours.
What are the official names of this protein?
Snaclec bothrojaracin subunit beta, BJC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: YJV3_YEAST
Sequence: MLMPKSVALLRIRYTLEAALARGFTTVRDCGGAEGFLKAEIRQGSLNGPRLITCGHAISQTGGHGDLRSGALPASAFDSCSCHFGQVGVVADGVPECYKAAREEFRRGADFIKIMGGGGVASPTDKISNKQFCDDEIKALVDVANSYHTYVTAHAYTAEAIQNCIKLGVKGIEHGNLLDERTAELMAELGCYLTPTLVTYKVMGSDQFSAFLGPENSRKNTEVLYKGIDAMKIAQKKKVKICFGSDLLGPLYGYQTQEFRIRGKVQTTQEILLSATVTPAEMNGLGDKLGQIKPGFIADLLMMKSNPLDDITILDEPESNILFVMKEGRIY
What are the official names of this protein?
Uncharacterized protein YJL213W.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily.
Protein: NPIIF_TRIVH
Sequence: MKFFTALAAVGALLAPALALPTPASEEASHNQTLSVRLVPAGHTMVRAIVTNNGERPLHLLSFNTILDEDPTSKVEVFHESGDEAEFLGMLPRYDLSDLTEDLFTRLAPKDSVEHLFDIATVHDLKWDGKYTLAARGAIPVAEDGGTTIIDHVYYESNELDMEIDARKAAMVPRAFDDYFSKSLDKRRPLDICNPRKERDLRAALEGAQQVAKEAAAAAQNNTEKVFEFFRARDPGTRKEVSQHLSSISRAATKDGSSVTWFCSDGPGRCGPRTIAYTFPAKNEVHPCPLFWQMPHVNNKCHRQDRVGTVIHEGAHNPSVVTPYCKDLGYGYNRATGLTSQRAKRNADNYALFAMARQLVFCLLHLFVALPFIYIFASF
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine.  May be involved in virulence (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog TRV_03208, Deuterolysin TRV_03208.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNHA1_STAA3
Sequence: MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit A1, Mnh complex subunit A1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX1_LEITA
Sequence: MFWLCLVCLSVSHKMIGLCYLLVAILSGFVGYVYSLFIRLELSLIGCGILFGDYQFYNVLITSHGLIMVFAFIMPVMMGGLVNYFIPVMAGFPDMVFPRLNNMSFWMYLAGFGCVVNGFLTEEGMGVGWTLYPTLICIDFHSSLACDFVMFAVHLLGISSILNSINLLGTLFCCRRKFFSFLSWSLFIWAALITAILLIITLPVLAGGVTLILCDRNFNTSFYDVVGGGDLILFQHIFWFFGHPEVYIILLPVFGLISTIVEVIGFRCVFSTVAMIYSMILIAILGMFVWAHHMFVVGMDVDSRAYFGGVSILIGLPTCVKLFNWIYSFLYTDMIITFEVYFVIMFIFMFLIGAVTGLFLSNVGIDIMLHDTYFVVGHFHYVLSLGAVVGFFTGFIHFLAKWLPIELYLFWMFYFISTLFIGSNMLFFPMHSLGMYAFPRRISDYPVSFLFWSSFMLYGMLLLASLILFLCALFCVFLFWDYCLFFVSLFVFSLYCFFYFSTWLPCVMVLYLLLVDFAHIVLDYLFLILCFCFVFFIFFWQSLFLFFYI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATPE_ENTFA
Sequence: MDSLTVNVVTPNGLVYDHHAKIVVAKTTDGEIGILPKHAPIIVPLAIDEVRIKRTDSDTHVDWVAVNGGIMEVRDNVVSIIADSAERERDIDVPRAERAKQRAERLIEEAKAKDDRDQLRRATVALHRAINRINVSKHG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TX21E_RHYMT
Sequence: MKDSYISIVIAYLMVTFILVSSMPIEGEKGELRPHRLSCPPKYASYHCFNGKCVHLVAQDEPGKPYYSCICDKFYIGERCDTLDITNPDYFLKGQSSTQSSI
What is the function of this protein?
Ant peptide with probable defensive activity which acts as a potent agonist of the mammalian epidermal growth factor receptor (EGFR).  Mimics, both structurally and functionally, vertebrate epidermal growth factor (EGF) peptide hormones.  In vivo, intraplantar injection in mice causes long-lasting (several days) hypersensitivity of the injected paw to both mechanical and thermal stimuli.  Its long-lasting effect is unusual for venom toxins whose effects are usually immediate.  One possible explanation is that it would reduce the duration of a nest attack, discourage future attacks, or enhance the actions of subsequent exposure to other pain-inducing venom peptides.
What are the official names of this protein?
OMEGA-ectatommitoxin(02)-Rm1e, ECTX2-Rm1e, OMEGA-ECTX2-Rm1e.
What is the protein family that this protein belongs to?
Belongs to the EGF domain peptide family.
Protein: YACG_HAEIE
Sequence: MSDEIIEVPCPICQKSVPWTNESTFRPFCSKRCQLIDLGEWAAEEKAIPSDTADFAMDPNVSDEWSIK
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: LEUC_STAHJ
Sequence: MGQTLFDKVWNKHVLTGNEGEPQLLYIDLHLIHEVTSPQAFEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDEIANKQITTLQKNAKEFGVQLFDMGSVEQGIVHMVGPETGLTQPGKTIVCGDSHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDVTGQLPKGVYAKDIILYLISQYGVDFGTGYAIEFTGETIRSLSMEARMTICNMAIEAGAKYGLMQPDEMTFAYVKDRKYARNFDRSINDWRQLYTDADAKFDKVIKLDVTNLEPQVTWGTNPEMGVSFNTPFPKIKNINDERAYQYMGLKPGQKAEDIDLGYVFLGSCTNARLSDLVEASRIVKGKQVHPKITAIVVPGSRSVKKEAEALGLDKIFKDAGFQWREPGCSMCLGMNPDQVPEGIHCASTSNRNFEGRQGKGARTHLVSPAMAAAAAIEGRFVDVRKVVV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RS6E_NITMS
Sequence: MANFKITISDTKGKSMSKELKDSDANPLLGLELGQETDASVVGLNGKLKLTGGSDKSGVPMRNDIHGAARKYVLLSKGVGLQDAEKGQRVRKLMRGNTVSEEIYQINCKFDGELPVEEAPAEDAPESAEEKSEDKKE
What are the official names of this protein?
30S ribosomal protein S6e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: RL27_ROSDO
Sequence: MAHKKAGGSSRNGRDSAGRRLGVKKYGGEAVIPGNIIVRQRGTKFWPAAGVGMGKDHTIFATVDGAVTFHKGLKNRTFISVLPVAEAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: Y2061_THEKO
Sequence: MAVMDPWLLITIIVGFGMAWAIGANDAANSMSTAVGAKAITPKQAVLIAGVLEFTGAYFFGKSVTETIRKGILYPDRITDPTVLIYGSVAALLAATIWLVIATKFGLPVSTTHSIIGGIVGYGIVYAGFSIVNWGKMTQVVLSWILSPIIGAIMAFLVFKALTKSIFERKDPVRSSKIWSPFWIGLAFVVIGTMFYIKVLHGKSLKTGVLFYGIPAGLVVFLILFLTLRVKFPSSDPFIGVESIFRRVQVITSGYVALAHGANDVANAIGPVAAVYAVATMGMAGMKVPVPRWILAMGGLGIAIGVATYGYRVMETVGKKITELTNTRGFTIDFSAATVVLVASWLGLPISTTHVVVGAVIGVGLARGVKAINKDIVRDIIISWFVTVPVAALISAFLFKILMIVG
What is the function of this protein?
Potential transporter for phosphate.
What are the official names of this protein?
Putative phosphate permease TK2061.
What is the protein family that this protein belongs to?
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TKFC_RAT
Sequence: MSSKKMVNSVEGCAGDALAGFVACNPDLQLLQGYRVALRSDLDSLKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFASPAVGSILAAIRAVAQAGTAGTLLIVKNYTGDRLNFGLAMEQAKAEGISVEMVVIEDDSAFTVLKKAGRRGLCGTILIHKVAGALAEEGMGLEEITKKVSVIAKAIGTLGVSLSPCSVPGTKPTFELAADEMELGLGIHGEAGVRRIKLVPVDQIVTLMLDHMTDTSNISHVPVKSGSSVVLMVNNLGGLSFLELGIIADAAIRLLEGRGVKVARALVGTFMSALEMRGVSLTLMLVDEPLLKLIDAETNAKAWPHMSKVSVTGRNRIRAAPTEPAEAPEATAAGGVASKQMTLVLDRISTTLIGLEEHLNALDRAAGDGDCGSTHSRAAKAIQGWLKEGPTPASPAQVLSKLSVLLLEKMGGSSGALYGLFLTAAAQPLKANTDLPAWSAAMDAGLKAMQKYGKAAPGDRTMLDSLWAAAQELQAWKSPGASLLPVLTKAVKSAEAAAEATKNMEAGAGRASYISSAQLDQPDPGAVAAAAIFRAILEVLQTKAA
What is the function of this protein?
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate (PubMed:16289032).  Represses IFIH1-mediated cellular antiviral response (By similarity).
What are the official names of this protein?
Triokinase/FMN cyclase, Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing).
What is the protein family that this protein belongs to?
Belongs to the dihydroxyacetone kinase (DAK) family.
Protein: SYFA_STRE4
Sequence: MDLQAQLEELKTKTQEALKQLNGDHSKELQELRVAVLGKKGTLTELLKGLKDLSNDLRPVVGKQVNELRDFLTQAFEEQAKVVEAAKIQAKLDSESIDVTLPGRQMKQGYRHVLTQISEEIEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQDTFYITEDILLRTHTSPVQARTLDQHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKSISMGDLKGTLEMIIKKMFGKERKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVLEMSGVNAQEYSGFAFGLGQERIAMLRYGINDIRGFYQGDSRFSKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPNP_SHIFL
Sequence: MLQSNEYFSGKVKSIGFSSSSTGRASVGVMVEGEYTFSTAEPEEMTVISGALNVLLPDATDWQVYEAGSVFNVPGHSEFHLQVAEPTSYLCRYL
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: OTC_MOUSE
Sequence: MLSNLRILLNNAALRKGHTSVVRHFWCGKPVQSQVQLKGRDLLTLKNFTGEEIQYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPSFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDTLAKEASIPIVNGLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDPNIVKLAEQYAKENGTKLSMTNDPLEAARGGNVLITDTWISMGQEDEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPVLQKPKF
What is the function of this protein?
Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline.  The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.
What are the official names of this protein?
Ornithine transcarbamylase, mitochondrial, OTCase, Ornithine carbamoyltransferase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RL18_LISMH
Sequence: MITKIDKNKVRKKRHARVRSKISGTESRPRLNVFRSNKNIYAQIIDDVNGVTLASASNLDKDFGSAESKVDAASKVGELVAKRASEKGITSVTFDRGGYLYHGRVKALAEAARENGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PUB2_ARATH
Sequence: MMVHMEVSWLRVLLDNISSYLSLSSMDDLSSNPAHKYYTRGEDIGKLIKPVLENLIDSDAAPSELLNNGFEELAQYVDELREQFQSWQPLSTRIFYVLRIESLASKLRESSLEVFQLLKHCEQHLPADLISPSFEECIELVKLVARDEISYTIDQALKDQKKGVGPTSEVLVKIAESTGLRSNQEILVEGVVLTNMKEDAELTDNDTEAEYLDGLISLTTQMHEYLSDIKQAQLRCPVRVPSDFRCSLSLELMTDPVIVASGQTFERVFIQKWIDMGLMVCPKTRQALSHTTLTPNFIVRAFLASWCETNNVYPPDPLELIHSSEPFPLLVESVRASSSENGHSESLDAEELRQVFSRSASAPGIVSEVVCKTKRNNNAAADRSLTRSNTPWKFPEERHWRHPGIIPATVRETGSSSSIETEVKKLIDDLKSSSLDTQREATARIRILARNSTDNRIVIARCEAIPSLVSLLYSTDERIQADAVTCLLNLSINDNNKSLIAESGAIVPLIHVLKTGYLEEAKANSAATLFSLSVIEEYKTEIGEAGAIEPLVDLLGSGSLSGKKDAATALFNLSIHHENKTKVIEAGAVRYLVELMDPAFGMVEKAVVVLANLATVREGKIAIGEEGGIPVLVEVVELGSARGKENATAALLQLCTHSPKFCNNVIREGVIPPLVALTKSGTARGKEKAQNLLKYFKAHRQSNQRRG
What is the function of this protein?
Functions as an E3 ubiquitin ligase.
What are the official names of this protein?
U-box domain-containing protein 2, Plant U-box protein 2, RING-type E3 ubiquitin transferase PUB2.
Protein: NDHI_CHLAT
Sequence: MFNFINNIQNYSKEAVQAAQYIGQGFMVTFDHMSRRPVTIQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPVVNWEFQKEKKKKQLQTYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELSVYDRHELNFDNFALGRLPSMVENDAMVKNMKGLGYLPKGVIESHASS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: GCH4_GEOSL
Sequence: MPDMQTSRDTRKIPISKVGVKDISYPIVVMDKNRKFQQTVARVNMYVDLPHHFKGTHMSRFIEILNAYREDIALDKMEPILQEMKKKLGASSAHLEIEFPYFIEKRAPVSGARSLMEYTCTFTGTLAETFDFVLGVQVPVTSLCPCSKELSRYGAHNQRSHITVRVRYAGFVWIEELVELIEGCGSSPVWSLLKRADEKFVTERAYENPKFVEDIVREATLALAAHEAITWFSVEAENFESIHKHSAYAAIEQDKRKA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: RL18_SACS2
Sequence: MNKLANGPNYKVKPRRRREGKTNYYKRYVYVISKQTRFIVRITNKYVIVQIAKIDPKGDIMIASAHSAELAKKFGWKGDENNTPAAYLTGYLAGLRAIKRGVTECVADIGLHVPSKGNRVFYVIKGAIDAGLKIPIGDISIENDRIKGEHIAKYAEKLKSENSDLYSKLFSRYLQRGLNPENLPSHFEEILNKIKSSGG
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: SEC66_YEAST
Sequence: MSEFNETKFSNNGTFFETEEPIVETKSISVYTPLIYVFILVVSLVMFASSYRKKQAKKISEQPSIFDENDAHDLYFQIKEMSENEKIHEKVLKAALLNRGAESVRRSLKLKELAPQINLLYKNGSIGEDYWKRFETEVKLIELEFKDTLQEAERLQPGWVQLFVMVCKEICFNQALSRRYQSILKRKEVCIKEWELKINNDGRLVN
What is the function of this protein?
Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex.  A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon.  SEC66 is required to attach or retain SEC72 in the SEC63 complex.  It is essential for growth at elevated temperatures.
What are the official names of this protein?
Translocation protein SEC66, Protein HSS1, Sec62/63 complex 31.5 kDa subunit.
What is the protein family that this protein belongs to?
To S.pombe SpBC409.21.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: MNMA_SALCH
Sequence: MSESPKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLEEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRADVNGKSRLLRGLDGNKDQSYFLYTLGHEQIAQSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFRDFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKDGTEDPWYVVDKDVENNVLIVAQGHEHPRLMSVGLIAQQLHWVDREPFTGTLRCTVKTRYRQTDIPCTINALDDDRIEVIFDEPVAAVTPGQSAVFYSGEVCLGGGIIEQRLPLTV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_STRAW
Sequence: MAGQKIRIRLKAYDHEVIDSSAKKIVETVTRTGASVAGPVPLPTEKNVYCVIKSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDSLMRLDLPAGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: MURA_ECO57
Sequence: MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNTQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAX_I000X
Sequence: MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELGDPSALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVSPREEKRQLKKGLKSQEQCASLPTKVSRRTSPALKILEPMWMDSNRTATLRASCLKCPKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: TPIS_CAMJD
Sequence: MIFAANLKCNHTRASFKIYAEILNKTMGAKCDDIIVFPPSVAFLENENNFMQGAQNFYPCVNGAFTGELGKEHLDEFGIKCVLIGHSERRALGDEELIKVKFNFAKEHGYKIIFCIGENLDTKNSGKTLEFLKKQLEIIDLNYEKLIIAYEPIYSIGTGVSAQTADIAKVLEFLASLTKVPLLYGGSVNENNIKEILSVNHCGGVLIGSAALKVENFIKLIKG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT1A_CONCL
Sequence: MTFLLLLVSVCMMATGEERTKRDVCELPFEEGPCFAAIRVYAYNAETGDCEQLTYGGCEGNGNRFATLEDCDNACARY
What are the official names of this protein?
Kunitz-type serine protease inhibitor conotoxin Cal9.1a, Conkunitzin-Cal9.1a.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGI2_RABIT
Sequence: MSYGSCVSRLLRTRVQSVLKKSVHSVAVIGAPFSQGQKRKGVECGPAAIRDAGLVKRLSDLGCRLKDYGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVNRAVSGGYSCVTVGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSPSIVYIGLRDVDPPEHFILKKYDIQYFSMRDIDRLGIQKVMEQTFDLLIGKKQRPIHLSFDIDAFDPTLAPATGTPGCGGADLSRRMYISEEIHNTGLLSALDLVEVNPRLAASDEEAKATASLAVDVIASSFGQTREGGHTVYEQLPPPSSPHESENAERVRI
What is the function of this protein?
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis.  Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS).  Arginine metabolism is a critical regulator of innate and adaptive immune responses.  Seems to be involved in negative regulation of the survival capacity of activated T cells.  May suppress inflammation-related signaling in asthmatic airway epithelium.  May play a role in promoting prenatal immune suppression.  Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction.  Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling.  Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.
What are the official names of this protein?
Arginase-2, mitochondrial, Arginase II, Type II arginase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
What are the subcellular locations of this protein?
Mitochondrion.