PharMolix/UniProtQA huggingface dataset:
Protein: FLIT_CITK8
Sequence: MTNFIPSLTDWHALHALSITMLDLAHSGKWDELIEQEMNYVQLVEGIARNPISPGNTFLINQAKEILNAVLRNEAELKTLLQHRMEELRQLIDQTGKQQSVSTTYGNLAGNILFPSNLNQ
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RDRP_REOVL
Sequence: MSSMILTQFRPFIESISGITDQSNDVFEDAAKAFSMFTRSDVYKALDEIPFSDDAMLPIPPTIYTKPSHDSYYYIDALNRVRRKTYQGPDDVYVPNCSIVELLEPHETLTSYGRLSEAIENRAKDGDSQARIATTYGRIAESQARQIKAPLEKFVLALLVSEAGGSLYDPVLQKYDEIPDLSHNCPLWCFREICRHISGPLPDRAPYLYLSAGVFWLMSPRMTSAIPPLLSDLVNLAILQQTAGLDPSLVKLGVQICLHAAASSSYAWFILKTKSIFPQNTLHSMYESLEGGYCPNLEWLEPRSDYKFMYMGVMPLSTKYARSAPSNDKKARELGEKYGLSSVVSELRKRTKTYVKHDFASVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQKDWTGPVGEIRILKDTTSSIARYLYRTWYLAAARMAAQPRTWDPLFQAIMRSQYVTARGGSGAALRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPFSHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYHMNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVIMAAIHEGVASGSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLSKLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETFLTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGNTAGKVNSETIQKMLELISKYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVGKERANSSAEEPWPAILDQIMGIFFNGVHDGLQWQRWIRYSWALCCAFSRQRTMIGESVGYLQYPMWSFVYWGLPLVKVFGSDPWIFSWYMPTGDLGMYSWISLIRPLMTRWMVANGYATDRCSPVFGNADYRRCFNEIKLYQGYYMAQLPRNPTKSGRAAPREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHNPPSLFDVPHKWYLGAQEAATATREELAEMDETLMRARRHSYSSFSKLLEAYLLVKWRMCEAREPSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQTLFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADALAGKIMLQDVSTVQLARVVNLAVPDTWMSLDFDSMFKHHVKLLPKDGRHLNTDIPPRMGWLRAILRFLGAGMVMTATGVAVDIYLEDIHGGGRALGQRFMTWMRQEGRSA
What is the function of this protein?
RNA-directed RNA polymerase that is involved in transcription and genome replication.  Following infection, it catalyzes the synthesis of fully conservative plus strands.  After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.
What are the official names of this protein?
RNA-directed RNA polymerase lambda-3, Lambda3, Lambda3(Pol).
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Found in the inner capsid (12 copies).
Protein: NADA_BURM9
Sequence: MQSAIKSVEYDRPLAAGAACGVGEAWAKVPDALAPDERDALKARIKALLVREKAVLVAHYYVDADLQALADETGGCVADSLEMARFGRDHDAHTLVVAGVRFMGETAKILSPGKRVLMPDLDATCSLDLGCPVDEFSQFCDAHPERTVVVYANTSAAVKARADWMVTSSIGLEIVADLHARGEKIIWAPDRHLGGYIQKKTGADMLMWQGSCLVHDEFKGIELDLLRHEYPDAKILVHPESPEGVVALADVVGSTTQLIDAAVKLDAQRFIVATDLGILHKMRLAAPGKTFIEAPTAGNSATCKSCAHCPWMAMNALSNLADVLERGHNEIFVEAAIAQRARMPIDRMLDFAARHKQRVQASGDLQRDQALFANVGAA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G3OX4_ARATH
Sequence: MPSLAEEICIGNLGSLQTLPESFTWKLTAADSLLRPSSAVSFDAVEESIPVIDLSNPDVTTLIGDASKTWGAFQIANHGISQKLLDDIESLSKTLFDMPSERKLEAASSDKGVSGYGEPRISPFFEKKMWSEGFTIADDSYRNHFNTLWPHDHTKYCGIIQEYVDEMEKLASRLLYCILGSLGVTVEDIEWAHKLEKSGSKVGRGAIRLNHYPVCPEPERAMGLAAHTDSTILTILHQSNTGGLQVFREESGWVTVEPAPGVLVVNIGDLFHILSNGKIPSVVHRAKVNHTRSRISIAYLWGGPAGDVQIAPISKLTGPAEPSLYRSITWKEYLQIKYEVFDKAMDAIRVVNPTN
What is the function of this protein?
Converts the inactive gibberellin (GA) precursors GA9 and GA20 in the bioactives gibberellins GA4 and GA1.  Involved in the production of bioactive GA for reproductive development.
What are the official names of this protein?
Gibberellin 3-beta-dioxygenase 4, GA 3-oxidase 4, AtGA3ox4, Gibberellin 3 beta-hydroxylase 4.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family. GA3OX subfamily.
Protein: VNP_OPHHA
Sequence: MVGPSRLAGGGLLLLLLALLPVALDGKPAPPSQALHKAPAGGTKASQIMQVLLPESKKSWAARDRMVGPYNPAGGGGGHPSSCFGHKIDRISHSSGMGCGRRPNAPAGGTKASQIMQVLLPESKKSRAARDRMVGPDNRAGGGGGGGGGDSSRQQELAKKDQHNNCFGRRIDRISHSTDLGCRRRPNPPPAPTAAPLAVAQFNSKSSQVA
What is the function of this protein?
Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity.  Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).
What are the official names of this protein?
Natriuretic peptide Oh-NP.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: AIM11_ZYGRC
Sequence: MNNVQFSERQISAFSHEYKIRRKRQMLRFFCATALTLVSCRVAYRGMLGRKYIPNMFQLNYKPPPFSYKGEAASALVLGTGLATGGLTMMVFGGCWIADISTFPEFSYKLKRLMGQESDSSQLPMDTETSQIVNQLEQLLNNDKK
What are the official names of this protein?
Altered inheritance of mitochondria protein 11.
What is the protein family that this protein belongs to?
Belongs to the AIM11 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RNFH_ECOSE
Sequence: MPGKIAVEVAYALPEKQYLQRVTLQEGATVEEAIRASGLLELRTDIDLTKNKVGIYSRPAKLSDSVHDGDRVEIYRPLIADPKELRRQRAEKSANK
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: CREL2_HUMAN
Sequence: MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAWEEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFCVKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECEVGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPAEAEATEGESPTQLPSREDL
What is the function of this protein?
Protein disulfide isomerase (By similarity).  Might play a role in the unfolded protein response (By similarity).  May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698).
What are the official names of this protein?
Protein disulfide isomerase CRELD2, Cysteine-rich with EGF-like domain protein 2.
What is the protein family that this protein belongs to?
Belongs to the CRELD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: TRPF_PYRAE
Sequence: MVLVKICGVVRVEDAVLLDGVADYIGFIVEPTSPRSVKPEALRSLRDAVIKSRPVLVTATIPPKEAVDIAAKNEIPVVQYHSTLAPKDFDYAETRGVTLAPVAVYKPGIELKQLVEELLKTPHEYVLVDADKKSQERYEGGLKIPLTLLAEVAPLGRVALAGGITPENAQLIARLNPYMIDVASGVEASPGVKDMNKVKALLKAVGRL
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: THIC_BACCQ
Sequence: MKQSVSAEQIELKSSLPGSKKVYVDGPREGMKVPMREIEQSDTNGVPNPPIRVYDTSGPYTDPAYKVELEKGIPTPRHSWILERGDVEAYEGREVKPEDDGVKVASKHTPVFPQMDRKPLRAKQGANVTQMHYARNGIITSEMEYVAIREGVEPEFVRKEIAEGRAILPANINHPEAEPMIIGRNFHVKVNANIGNSAVSSSIAEEVEKMTWATRWGADTIMDLSTGKNIHTTREWIIRNAPVPVGTVPIYQALEKVNGIAEDLTWEVYRDTLIEQAEQGVDYFTIHAGVLLRYIPITAKRTTGIVSRGGSIMAQWCLFHHKENFLYTHFEEICEIMKQYDVSFSLGDGLRPGSIADANDEAQFSELETLGELTKIAWKHDVQVMIEGPGHVPMHLIKENMEKELDICQGAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNKDDVREGVITYKIAAHAADLAKGHKTAHQRDDALSKARFEFRWRDQFNLSLDPERAMEYHDETLPAEGAKTAHFCSMCGPKFCSMRISHDIREYAKENDLETTEAIEKGMKEKAKEFKDTGSHLYQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: CCA_STRA3
Sequence: MRLNYLPSEFQKALPILKKIKKAGYEAYFVGGSVRDVLLDRPIHDVDIATSSYPEETKQIFKRTVDVGIEHGTVLVLEKGGEYEITTFRTEEVYVDYRRPSQVNFVRSLEEDLKRRDFTVNAFALNEDGEVIDLFHGLDDLDNHLLRAVGLASERFNEDALRIMRGLRFSASLNFDIETTTFEAMKKHASLLEKISVERSFIEFDKLLLAPYWRKGMLALIDSHAFNYLPCLKNRELQLSAFLSQLDKDFLFETSEQAWASLILSMEVEHTKTFLKKWKTSTHFQKDVEHIVDVYRIREQMGLTKEHLYRYGKTIIKQAEGIRKARGLMVDFEKIEQLDSELAIHDRHEIVVNGGTLIKKLGIKPGPQMGDIISQIELAIVLGQLINEEEAILHFVKQYLMD
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: RPPH_SALSV
Sequence: MIDDDGYRPNVGIVICNRQGQVMWARRFGQHSWQFPQGGINPGESAEQAMYRELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLMSADAEINMQTSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFASVVMALQDNPPKLQSAPAYRRKRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: PUR4_SCHPO
Sequence: MLVYYGGSALSVQSKKKILELTVSGVSDLNAVYFYLIYTKSNSSLNCESLRPILSDLQESEFKPDGTTMVYVFPRPGTISPWSSKATNIANVCGYKDVIRIERGIAYSVVFKDDISEEMLKSALNHLYDRMTEALRFKLPEEDEVFDKHEPAPLVRIELNCGQGGDKQAATERLNHANKKFGLALAPDEIDYLVECYTSEPSLKSREPTDVELFMFGQVNSEHCRHKIFNADWTIDGEKKDYSLFKMIRNTHLKNPQYTISAYSDNAAVFEGNSGTLFAPVNGIWSMKDEPVEFLGKVETHNHPTAVSPFPGAATGSGGEIRDEGAVGQGSLSKAGLAGYSVSDLNIPGYKQPWELDVGKPYHIATSLDIMLEAPIGSSAFNNEFGRPCINGYFRTFCMEVPRGDGTLEIRGYHKPIMAAGGIGRIRKQHAFKKSIAPGSPIIVLGGPALLVGLGGGAASSMNAGEGSEELDFASVQRGNPEMQRRAQMVIDACTTMDENIIQSIHDVGAGGVSNALPELVHDAGLGARFELRDIPCIEPSMSPMQIWCCESQERYVLSVKSEDLDTFKSICERERCPYGVVGYSTVEQRLILTDRLYNTTPIDLPMEVLFGKPPKMSRVAETQTIPLSKFDSSLKSYLAPSSDPILDAVERVLRMPAVASKSFLITIGDRSVTGLIARDQMVGPWQVPVADVGVTVTSYGKGINTGEALAMGEKPISALVSAAASARMAVAECIMNLVAASIPALDRIRLSANWMAAPSHPGEGAKLYEAVQAIGLELCPSLGISIPVGKDSMSMSMKWNEDGREKSVTAPLSLIITGFSPVDDLYSIWTPQLRKVEDIGSTSLIFIDLANGKQRLGGSILAQSYKQLGDEVPDLDNLDTFKNFINVITQLHKTNYIQAYHDKSDGGLFVTLSEMAFAGHVGIECELDSLSSDNIAALFNEELGAVIQVCDRDIAKVLELFAANGLSTCVHRIGKVLSGQAQTISFSRSGKIIFKSTRSKLHGIWHETSYKMQEIRDNPECARQEMENIADNNDPGLGYHLTFDPNVSVTADLALTSRPKVAILREQGVNGYLEMAYAFYASGFTAVDVHMTDILSGRVHLDDFVGIAACGGFSYGDVLGSGNGWATSILLHEDARNEFYRFFNERKDTFGLGICNGCQLFSRLKSLIPGAKSWPMFTFNESAQYEGRAVMLKIDETSGSKSIFTESMAGSSLPVVVAHGEGRAVFDSESDYEQFKKEGLDLIYYVNNYNERTSRYPFNPNGSRDAIAGVRSPCGRFLAMMPHPERVVLKVANSYYPHSKASEWGVHGPWIRLFQSARKWVG
What is the function of this protein?
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway (PubMed:967158).  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (PubMed:967158).
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase, FGAM synthase, FGAMS, Formylglycinamide ribonucleotide amidotransferase, FGAR amidotransferase, FGAR-AT, Formylglycinamide ribotide amidotransferase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITP_PSHV1
Sequence: MAPKSACKNALAQLAAELSSASKRDTSSGSTRNSAPELTSLLADLLLSRDDVPLEDLEATTARSHLAKGVFAACKLVPFPVAEVAVRLAVRAIMRRVVVPWQAGENFSMIQRVREAFLRLVDDFDNASKTELNAPFTQCSEYKDLIGGWLTQFGNAVVLTMSEQQLLDDAGSVLNPPEVLAPLVERYPLLIDHVMVQEGMDYLGGKLQSLVAYHALLRCATRPHENGKVPVLAALTMVAEYFDPETKPAYRKVPQKAVAAFDLNLTDEVVSSLVYDQAAAPVVQSEQPVLPQSESLLFTEVVRTRNMLALVQPSATWEGSGAALRNAAGDAKRRQQQAARGAGMAWRCGVDALFSVPMEHVAMNVPAVMQMLHEPPTDIPAEYERALSLYATDTIDAIAKFPDLAASSGTEAVIRSLALRGFTKTNCERYLFAAEAFLEPQAPGTPLHDFYAAVIYASVVGLAAHSLYAYNQHTIFYPEKYSRVLKKTVEAHAYLLDMMGLAISDALISLRAFAPKPPHQAFRTVRDTLAAVVDSVETGAEEFSDLIVSDYVQRLTADFYGGIHENEQWLSERDAAIRQRMEIAAAGRRETDSAGRRPGLGFHELAALVQGLQIGGKEPKAVVEYATAPAGAASAGATFSALFAAAIVRDVMEGAAAIPFEADALARLNKALSWLRDFGLSWNMPDGSHYRRRVIALQAAIHPFVTGKIGVDAVTVKQARALETAMGDLYAACEYSFQALPPPYVGGLRKAAAPSRQHSPLLAQAYTNAAMGDLGVLTKTLAKSAEEISKTVRDMVSRLLSARDLFSRRATASDKNAVTIDAAGPGGTVLGTWEDESVMSGLWKTVNFTEAAIRNTERAVRELEATKRETQDLEESYWQLASGRDGAGNAAQPSESLYQQVAAELVEIADARNAVVVRARSLYRAIAGTGLKRIRTFVKAWRLFLKAERSLAKQVVQQQDLIDALDPSRS
What is the function of this protein?
Plays an essential role in cytoplasmic secondary envelopment during viral egress.  Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs.  Modulates tegumentation and capsid accumulation at the viral assembly complex.
What are the official names of this protein?
Inner tegument protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae inner tegument protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus, host trans-Golgi network.
Protein: MDTK_SALNS
Sequence: MQKYTSEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLVMIVLWNAGYIIRSMHNIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFLGLLVNIPVNYIFIYGHFGMPELGGIGCGVATAAVYWVMFIAMLSYIKHARSMRDIRNEKGFGKPDSVVMKRLIQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLGAQTAARTGLGVGICMAVVTAIFTVTLRKHIALLYNDNPEVVALAAQLMLLAAVYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYILALTDLVVDRMGPAGFWMGFIIGLTSAAVLMMLRMRYLQRQPSAIILQRAAR
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PFKA_HALH5
Sequence: MKRIGVLTSGGDSPGMNAAIRAVVRKAIYHGVEVYGIYQGYAGLISGDIRKMELGSVGDIIHRGGTILYTARCEEFKTLEGQKKGIEQLKKFGIEGLVVIGGDGSFAGAQKLTEHGFPTVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSHDRTYVIEVMGRNAGDLALWSGLADGAETIVIPEADHDIDQIISRLQRGQERGKKHSIIVVAEGVGSGMDFGREISERTGAETRVTVLGHIQRGGSPTGFDRVLASRLGAKAVDLLLEGQAGVTVGIENNKLVHHDITEVLQRKHSIDLDMYRLSQELSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
Protein: THIM_STRSY
Sequence: MYLEKLRSQNPLTICITNDVVKNFTANGLLALGASPAMSEYPEDLEDLLPYTKGLLINTGTLTNETWELYKSALDIAEKYGVPTVLDPVAAGAGAYRKKVTLDLLHHHTISLVRGNAGEIAALIGESIETKGVDSAQIDNVGELALRANQQLGIPVVITGKKDAVAVNHQVRILENGSELMPLVTGTGCLLGAVLAAFIHLADEDSLLDCLEEVLSAYSIAGEMAEQKTSLPGTFQIEFINSLYAIQSEEVEENKKVIHYE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: NUOB_METFK
Sequence: MSIEGVLEKGFVTTTLDTVINYTRTGSLWPMTFGLACCAVEMMHAGAARYDLDRFGIVFRPSPRQSDVMIVAGTLVNKMAPALRKVYDQMAEPRWVISMGSCANGGGYYHYSYAVVRGCDRIVPVDVYVPGCPPTAEALLYGIIQLQNKIKRTNTIAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LEUD_NAUPA
Sequence: MNVITGRVWKFGDNIDTDLIIPARYLNTSDPHELAKHVMEDADPEFPSKVRPGDIIVAGYNFGSGSSREHAPIALKAAGVAAVIAKSFARIFYRNSFNMGLPIFELLESDEINEGDLIKIDLDNGIIHNVDTGKDYKFTPIPEFMQELIAAGGLINFAKEMLKENK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: AROK_CLOB6
Sequence: MENIVLIGMPLSGKSTLGREISKILKYDLIDTDTLIEKMEGKSIKEIFKIYGEDYFREKELEIINKLKKESNKVISTGGGLPIYNKNIYELKKIGFTVYLKVPLEELIKRMVKKGEDTRPLLKNNDTKFLEEMYKNRIEIYEKAHTIICNTNHEESLITIVRAYKKWKGI
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_ACTSZ
Sequence: MSNSTALFQRARQVIPGGVNSPVRAFKGVGGTPVFIQKAAGAYITDTDGKQYIDYVGSWGPMVLGHNHPAIIDAVLKAVPNGLSFGAPTEGEITLAELVCRLIPSIELVRMVSSGTEATMSAIRLARGYTKRDKIIKFEGCYHGHSDSLLVKAGSGALTLGQPSSPGVPEDFAKHTLTCTYNDLNSVKCAFERYPQDIACLIIEPVAGNMNCVPPKPGFLQGVRELCDQYGALLIIDEVMTGFRVALGGAQAYYGVTPDLTALGKIIGGGMPVGAFGGKREIMEYIAPTGPVYQAGTLSGNPIAMAAGLACLTELSKPGNEQQLAEKTQQLAEGLKTLAKKHGVPFIAQYVGGMFGLFFTDVPEVTNFQDVMKCDVAKFNRFFHLMLEQGVYLAPSAFEAGFMSLAHSDADIEQTLKAADNAFAVLA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_PARPJ
Sequence: MKRIALGVQYDGSAFCGWQSQPHRNTVQDELERALREFARTPVQTVVAGRTDTGVHGLGQVVHFDTELDRADVSWVRGTNSFLPKTISVQWAKPMPDEFHARFSAFERTYYYVLYVHPVRSPMLATRAGWVHTSLDVDAMQKAAAHLLGEHDFSAFRSSQCQAKTPVKHLYQIDVKQQGDFVHFRFRANAFLHHMVRNLMGCLVYIGGGRRPVEWMAEVLASRDRDFAAPTFMPDGLYLAQVGYPEQFAVPAPQTGSVPWNTVWTEQAQT
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: TETD_ECOLX
Sequence: MYIEQHSRYQNKANNIQLEYDDRQFHTTVIKDVLLWIEHNLDQSLLLDDVANKAGYTKWYFQRLFKKVTGVTLASYIRARRLTKAAVELRLTKKTILEIALKYQFDSQQSFTRRFKYIFKVTPSYYRRNKLWELEAMH
What are the official names of this protein?
Transposon Tn10 TetD protein, ORFR.
Protein: GAIP_CUCMA
Sequence: MKREHHYLHPRPEPPSVATGSNRESYLNTGKAKLWEEEVQLDGGMDELLAVLGYKVKSSDMAEVAQKLEQLEEAMCQVQDTGLSHLAFDTVHYNPSDLSTWVESMLTELHPPPTSHLDDSSFLAPAESSTIANVDYEPQLQTSSRIFEESSSSDYDLKAITDSAIYSPRESKRLKASESDTDVFSTSAIGASNFATRPVVLVDSQENGIQLVHALMVCAEAVQQNNLNLAEALVKRIDYLAVSQAGAMRKVATFFAEALARRIYRLCPENPLDRSVLDMLQMHFYESCPYLKFAHFTANQAILEAFEGKKRVHVIDFSMNQGIQWPALIQALALRPSGPPTFRLTGIGPPAPDNSDYLQDVGWKLVKFAETLHVEFEYRGFVANSLADLDASMLELRPSEVESVVVNSVFELHQLLARPGAIEKVLSVVKQMKPEIVTVVEQEANHNGPVFVERFTESLHYYSTLFDSLECSPNSQDKMMSEMYLGKQICNVVACEGADRVERHETLTQWRTRLSSAGFDPIHLGSNAFKQASILLALFGSGEGYRVEENEGSLMLGWHTRPLIATSAWKPGNNPVVAH
What is the function of this protein?
Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway.  Probably acts by participating in large multiprotein complexes that represses transcription of GA-inducible genes.  Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway (By similarity).
What are the official names of this protein?
DELLA protein GAIP, CmGAIP, GAIP, Gibberellic acid-insensitive phloem protein.
What is the protein family that this protein belongs to?
Belongs to the GRAS family. DELLA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTMR9_HUMAN
Sequence: MEFAELIKTPRVDNVVLHRPFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDKRFVGSLGTIIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEANNLVIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLAELETEDGMQESP
What is the function of this protein?
Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598).  Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598).  Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity).  Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598).  The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970).  Stabilizes MTMR8 protein levels (PubMed:22647598).  Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580).  Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598).  Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598).  Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970).
What are the official names of this protein?
Myotubularin-related protein 9, Inactive phosphatidylinositol 3-phosphatase 9.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.