PharMolix/UniProtQA huggingface dataset:
Protein: RF1_NATTJ
Sequence: MLDKLEGIEKRYQELEDLMSDPEVINDPEKLKQYSKEHASLEEIVNKYRQYLETKQEFEEAKEMLEENDEDPDMEEFLKDEIPRLENQMQEIYDSLKILLLPKDPNDEKNVIVEIRAGAGGDEAALFAADLYRMYTRYAEIMNWKTEIMDSHEKDMGGFKEIVFMIEGKNAYSRLKFESGVHRVQRVPSTESSGRIHTSTATVAVLPEAEDVEIEIDTNELRIDTFCATGPGGQSVNTTQSAVRITHEPTGVVVSCQDEKSQHKNRDKAMKVLRARIYDMYLEEQQQQEAEERKSQVGSGDRSERIRTYNFPQGRITDHRINFTTHRLEQVLEGEIDELIDALITTEQAEQLKKMGA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPH_GNEPA
Sequence: MNPIISAASVIAAGLAVGLASIGPGVGQGTAAGQALEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NS4_CVRSD
Sequence: MAALGHKAKLAAVFIGPFIVACMLGISLVYLYQLQVQIFHVNNTIRVTGKPATVSYTLSTPVTPVATTLDGTTYTLIRPTSSYTRVYLGKTRGFDTSTFGPKVLNYITSSKPHLNSGRPYTFRHMPKYMTPSATWRFGM
What are the official names of this protein?
Non-structural protein 4, 15 kDa non-structural protein, Accessory protein 4, ns4.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses ns4/ns4.8 protein family.
Protein: PPR1B_RAT
Sequence: MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPALLFRVSEHSSPEEESSPHQRTSGEGHHPKSKRPNPCAYTPPSLKAVQRIAESHLQTISNLSENQASEEEDELGELRELGYPQEDDEEDEDEDEEEDEEEDSQAEVLKGSRGTAGQKLTSGQGLEGPWERPPPLDEPQRDGNSEDQGEGRATQSEPGEEPRHPTPPESGT
What is the function of this protein?
Inhibitor of protein-phosphatase 1.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 1B, DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the protein phosphatase inhibitor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH5_DICDI
Sequence: MFLFKTTNNLRKSLSNKFFCTRYSKNHLWISINNNNNSNNNNNNNNNIIIGTLGLTENGPINKFDDVLYIKFPIIKDENQVDDEPLTISLDTISDQILLNSPIRNCKLISINQDVLDYPNYINSSPMSKGWLCKIKFSNINDFNSLMNKNEYDNYCKNKIIKI
What are the official names of this protein?
Glycine cleavage system H-like protein gcvH5, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y2919_MYCBO
Sequence: MAGRPLHAFEVVATRHLAPHMVRVVLGGSGFDTFVPSDFTDSYIKLVFVDDDVDVGRLPRPLTLDSFADLPTAKRPPVRTMTVRHVDAAAREIAVDIVLHGEHGVAGPWAAGAQRGQPIYLMGPGGAYAPDPAADWHLLAGDESAIPAIAAALEALPPDAIGRAFIEVAGPDDEIGLTAPDAVEVNWVYRGGRADLVPEDRAGDHAPLIEAVTTTAWLPGQVHVFIHGEAQAVMHNLRPYVRNERGVDAKWASSISGYWRRGRTEEMFRKWKKELAEAEAGTH
What are the official names of this protein?
Uncharacterized protein Mb2919c.
Protein: RL37_METBU
Sequence: MSKGTPSMGKRQKRTHAKCRRCGSVSLNIHTKQCTSCGFGRTSRMRSYQWQRKCKF
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L37e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL37 family.
Protein: OPGG_ECO57
Sequence: MMKMRWLSAAVMLTLYTSSSWAFSIDDVAKQAQSLAGKGYEAPKSNLPSVFRDMKYADYQQIQFNHDKAYWNNLKTPFKLEFYHQGMYFDTPVKINEVTATAVKRIKYSPDYFTFGDVQHDKDTVKDLGFAGFKVLYPINSKDKNDEIVSMLGASYFRVIGAGQVYGLSARGLAIDTALPSGEEFPRFKEFWIERPKPTDKRLTIYALLDSPRATGAYKFVVMPGRDTVVDVQSKIYLRDKVGKLGVAPLTSMFLFGPNQPSPANNYRPELHDSNGLSIHAGNGEWIWRPLNNPKHLAVSSFSMENPQGFGLLQRGRDFSRFEDLDDRYDLRPSAWVTPKGEWGKGSVELVEIPTNDETNDNIVAYWTPDQLPEPGKEMNFKYTITFSRDEDKLHAPDNAWVQQTRRSTGDVKQSNLIRQPDGTIAFVVDFTGAEMKKLPEDTPVTAQTSIGDNGEIVESTVRYNPVTKGWRLVMRVKVKDAKKTTEMRAALVNADQTLSETWSYQLPANE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CRTAM_HUMAN
Sequence: MWWRVLSLLAWFPLQEASLTNHTETITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQGRKLVAPFRFEDLVTDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLGLARKKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEETSSEEKNGQSSHPMRCMNYITKLYSEAKTKRKENVQHSKLEEKHIQVPESIV
What is the function of this protein?
Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity).  Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).  Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity).  Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity).  Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity).  By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity).  Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity).  Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).
What are the official names of this protein?
Cytotoxic and regulatory T-cell molecule, Class-I MHC-restricted T-cell-associated molecule.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation.
Protein: Y119_METJA
Sequence: MDSWNMKGSKMVDVNEITKYLPGFNCGACGYKRCDLFAEALLNKDVKLEDCPFLLRERFKENYEKLKEILKIKGKIKKEEKYIGVIDGYEADFLLKPLPNECSCRETLLIMDKKELKVGDYIRYRPLGCPIPHFAKIIDEYHGFYIIHVVGPSHRITGEKIEYKDVGIAIVVAFEGIVEGKVPEVGKTVKFIPKHCMMQKVHSGVVVQVEGKRVYIEGIDLKVF
What are the official names of this protein?
Uncharacterized protein MJ0119.
Protein: Y241_ARCFU
Sequence: MILKPIGVVKSPFKTQNDAPRQGRFSDAVSEIAIFDEYADGLHKIENLRHIIVLYWMDKASRDKLRVVPPGETEERGVFTTRSPSRPNPIGLCVVEILEVERNRLKVRWLDALDGSPVIDIKKYSPEIDCVNQLEGQQP
What are the official names of this protein?
S-adenosyl-L-methionine-binding protein AF_0241.
What is the protein family that this protein belongs to?
Belongs to the tRNA methyltransferase O family.
Protein: GST_ANOGA
Sequence: MPDYKVYYFNVKALGEPLRFLLSYGNLPFDDVRITREEWPALKPTMPMGQMPVLEVDGKKVHQSVAMSRYLANQVGLAGADDWENLMIDTVVDTVNDFRLKIAIVAYEPDDMVKEKKMVTLNNEVIPFYLTKLNVIAKENNGHLVLGKPTWADVYFAGILDYLNYLTKTNLLENFPNLQEVVQKVLDNENVKAYIAKRPITEV
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase, GST class-sigma.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Sigma family.
Protein: MNMA_PHOPR
Sequence: MRLKRNMSDNSQKKVIVGMSGGVDSSVSAYLLLQQGYQVEGLFMKNWEEDDNEEYCSAAEDLADAQAVCDKLGIHLHTINFAAEYWDNVFEYFLAEYKAGRTPNPDILCNKEIKFKAFLEFADEVLEADYIAMGHYTRRSFPTAEGEKPKMLRGVDSNKDQSYFLYTLSHEQIARSLFPVGELEKPEVRRIAEEQDLITAKKKDSTGICFIGERKFTEFLGKYLPAQPGKIETADEGKVIGEHQGLMYHTLGQRKGLHIGGQKGGNGLEDAWYVVDKDLKRNVLIVGQGKDHPRLKSNGLVASQLDWVDRQPIRETMTCTVKTRYRQEDIPCTIIPIDDENIKVIFDEPQIAVTPGQSAVFYSNEICLGGGIIEQRI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSBP2_HUMAN
Sequence: MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF
What is the function of this protein?
Binds 7-ketocholesterol.
What are the official names of this protein?
Oxysterol-binding protein 2, Oxysterol-binding protein-related protein 4, ORP-4, OSBP-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: RS5_BEUC1
Sequence: MAAPQRSRTTGAPSSGGPSENERGRGGDRRGGDRRGGDRRGGDDRNQFVERVVTINRVAKVVKGGRRFSFTALVVVGDGDGTVGVGYGKAKEVPTAIAKGVEEAKKNFFRVPRIQGTIPHSVRGEAAAGVVFLRPASPGTGVIAGGPVRAVLDCAGIHDVLSKSLGSSNAINIVHATVAALQGLEEPAAVAARRGLPLEDVVPGPILRAQARGRADAAAKASTGVA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RL9_AGARV
Sequence: MKVILLQDVKPLGKKGEIVNVSDGYARNNIIPKKLGVEATPKNLNDLKLQNQHADKVAQENYESALALAKVVENTKVVVKLRSGEGGRTFGSISTKEISAAAKEQHGLELDKKKMQLNESIKALGNYEVPVKLHPKVTANLTVSVVEG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ANMK_BACMK
Sequence: MYIAGIMSGTSLDGIDVALVHVEGNGVDSKVELIHFTTVPFCKDIKNEILQALSIDTSNVQLICSLNFKLGLCFANAVEEVCKKADLSLEQLDLIGSHGQTIYHQPKQEGNSISSTLQIGEPAVIAYETNTTVISNFRTMDMAAGGQGAPLVPYSEVILYRHQTKNRLLQNIGGIGNVTVVPSHLSDKSVIAFDTGPGNMVIDDVCQRLFQLPYDQNGRIAKQGVVVDEILTYCMNHPFLKMNPPKSTGREQFGEEFVSELLKRFEKHGKENLLTTVTMFTASSIVHHYKEFILPYYEIDEVILGGGGSYNRTLVEMIRNGLKEEKCAIFIQEDIGYSSEAKEAIAFAILANETHHRNPSNVPSATGAKQSVVLGNITFPPIR
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: EIF3I_ASPFU
Sequence: MRPILLSGHERSLNQIKFNRDGDLLFSVAKDKIVCAWWSANGERLGTYSGHQGAIWTVDVSPNTVLLATGSADNTVRLWNVKTGECVKVWDFPTAVKRVAFNPDGSRLLAVTEKRMGFLGTIAVLDINYGDSQGGGLENQADEPSLRITCTESKATVAGWSYLGKYIIAGHEDGSVSQYDGKTGEQLENVQAHEFDHQINDIQFSQDRTYFITASKDKSAKLISSRNLAILKTYVADTPLNSATITPKKDYVILGGGQAAMDVTTTSARQGKFEARFYHKVFEDEIGRVRGHFGPLNTVDVHPNGTAYASGGEDGYVRVHHFDKPYFDFMYEVEREQLRK
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit I, eIF3i, Eukaryotic translation initiation factor 3 39 kDa subunit homolog, eIF-3 39 kDa subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit I family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_CAMJ8
Sequence: MQIMLCAISNIASGNCSEDCKYCTQSAHVKTDIQKYRRKELSQIVLEAKMAKKNEALGFCLVTAGLGLDDEKLEYVCEAAKAVQKEVPNLLLIACNGMASVEQLKELKKAGIFSYNHNLETSKEFFPQICTTHTWESRFQTNLNAKEAGLMLCCGGIYGMGESEEDRLSFRKSLQELQPFSTPINFFIANENLKLQVPRLSADEALKIVRDTKEALPQSVVMVAGGREVVLQERQYEIFQAGAGAIVIGDYLTTKGEEPSQDIIKLKEMGFTFASECH
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: LGT_UREPA
Sequence: MQLEIINPESTLVNDVVAHRVAFSIGSNFNIYWYGIIFVCGFLIAILTYSLRLKFHYKVPYDPGFYYIFLAIPMTIIGARLWSLAIGDAKDFFDFRSGGLAIQGGVIAGVLSAAVYFPLILRMPKYHIRDIDADGNVVIRQPSMWIYADAIIPTILIGQALGRWGNFINGEIFGAESTVNDLQWLKKAMPAVFEGMKHYFIEGNKTLFTIYQPLFLYESFFNVIVFVFIYFGLSYIKQLKIGFISMSYFFFYGVTRFSTESARAPQFSFEGTYIINSLLLIFGVLGALYVQFIAPLLRKKFLLDAIIEMFYKKKDQIHKFGELRKPEEFLFYCHK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYFA_LEGPL
Sequence: MLVLINTIQEQASEAIKQATDIVALEQIRVDFLGKKGKLTELLKGLANLSAEEKPKVGQLVNQAKQGISALIETKMIELKEKQLLAKLAAEQIDVTLPGRNHSTGSLHPVTQVKHRINDYFSRLGFDIVEGPEIETEFYNFEALNIPGHHPARAMHDTFYFGDGRLLRTHTSPVQIRTMEQRKPPFRLIAPGRVYRCDSDVTHTPMFHQVEGLLIDKQATLAGLKGLLQDFFSYFFGRELALRFRPSYFPFTEPSAEVDIECTQCNGKGCRSCKFTGWLEVLGCGMVHPNVLIAVNIDPNEYHGWAFGMGMDRLAMLYYGIDDLRMLFENDLTFLRQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTH_ECO27
Sequence: MTNYRVESSSGRAARKMRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPFVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELIFSQPNLAQLGKGMVIPSLPTSEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGSRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGVADLDEAYLTLQPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFIRFHIPLWVRRTVTMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSDSKLMGDLVNSKRVKQTGWVIVVLVVALNIWLLVGTALGL
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BIOD_RHOBA
Sequence: MASLYFVTGTDTEVGKTYCTAKTVERMRECGQRVGVYKPVASGCELRADGQRYSVDAATLWQAAGRPKNIDAVCPQRFLAALSPPQSAAREGVKVDTRQLRDGLAIWCDGDFDVVMIEGAGGLFSPISDDWLNVDLAIEMKRWSDQNGHSFELLLVAPDRLGVLHHVISTSRAAESAGIPIAGLILNRMDDHADESTQTNAEDLRRWCGIPMVASVRQPSGPLVVFSGPNGRNASGETSRETAGGVNFLNQTTIRR
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_RICAH
Sequence: MNHIDFGFKKVDYTKKQGLVNSVFSNVADKYDLMNDLMSFGLHRLWKDEFIRRIPNLNSHILDVASGSGDIALKLAKKARDRGNNIALTLSDINEEMLKNAKKKTIDLNLFQNLKFTVASAEELPYPDNSFDYYTIAFGIRNVPDINKALKEAYRVLKPMGKFICLEFSKVKESYFKDFYKFYSFSIIPTIGQVITGNKEAYEYLVESIELFPSQDEFRIMIKEAGFEEVGYKNLSGGIVAIHSGYKI
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: QUEC_STAES
Sequence: MSQNDLNKEKALVVFSGGQDSTTCLFYAKKHFKEVELVTFNYGQRHDKEIEVAKKIAKEQNLKHHILDMSLLSQLTPNALTQHELSIEDNDDGIPNTFVPARNLLFLSFAGALAYQIHAKHIITGVCETDFSGYPDCRDSFIKSMNVTLSLSMDKDFVIHTPLMWLDKAQTWALSDKLGVLDYIRHNTLTCYNGIIGDGCGECPACHLRARGLKHYLEHKGEE
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: INSL4_HUMAN
Sequence: MASLFRSYLPAIWLLLSQLLRESLAAELRGCGPRFGKHLLSYCPMPEKTFTTTPGGWLLESGRPKEMVSTSNNKDGQALGTTSEFIPNLSPELKKPLSEGQPSLKKIILSRKKRSGRHRFDPFCCEVICDDGTSVKLCT
What is the function of this protein?
May play an important role in trophoblast development and in the regulation of bone formation.
What are the official names of this protein?
Early placenta insulin-like peptide, EPIL, Insulin-like peptide 4, Placentin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GL114_ARATH
Sequence: MRFSKSLILITLSALVISFAEANDPSPLQDFCVAIGDLKNGVFVNGKFCKDPKQAKAEDFFYSGLNQAGTTNNKVKSNVTTVNVDQIPGLNTLGISLVRIDYAPYGQNPPHTHPRATEILVLVEGTLYVGFVSSNQDNNRLFAKVLNPGDVFVFPIGMIHFQVNIGKTPAVAFAGLSSQNAGVITIADTVFGSTPPINPDILAQAFQLDVNVVKDLEAKFKN
What is the function of this protein?
May play a role in plant defense.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Germin-like protein subfamily 1 member 14.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: 273R_IIV6
Sequence: MQNAEIFYKACKNAFTRKEYIFPSGRKEFVLGYEDKCLDCLLEIYCEDDIIVDPRLIPTFKYEKLRDDGTIYSAKYFPDVLIVNDHGNYFIEVKSEWTYKIDTVNIHKKIKSVTESGYDIELWIYNSKKNSKKRTF
What are the official names of this protein?
Uncharacterized protein 273R.
Protein: Y3961_BACCR
Sequence: MEYQYPLDYDWSNEEMVTMVKFYEAIEKAYEKGIIREELMGLYRRFKEIVPSKAEEKKIDKEFQEVSGYSIYRAIQRAKEVEEQKLVKM
What are the official names of this protein?
UPF0223 protein BC_3961.
What is the protein family that this protein belongs to?
Belongs to the UPF0223 family.
Protein: AC891_PENRF
Sequence: MFFSQPTHLAKAEELKQAPPKGVAYSVALPGTEQPGRSPVYRAWNAQKELLTTLDPEVTTAHDIFESTAIRHPKNDCLGWRPYNSTTKSFDPYQWLTYETVQKRRAAFGAGIVELHHKHDCHRPGQYGVGLWSQNRPEWQITDLACVSQSLYSVSIYDVLSEDATEYIINHSELSCVVTSLPHIASLIKLKPSLPTLKIIISLDPLDGGEQAGHSKRAIFESMAAGLGLAIYTIDQVEELGLASKRGYNPPSASDIVTINYTSGTTGPPKGVVLTHGNAVAATSCGLITISQARGDTSASYLPLAHIYARLAEHTAFWGAARIGYFHGNIAELVDDLKLLKPTGFMSVPRLYSRFGSAIRAATVEQPGFKGALSRHIIAAKTANMKNPDPSKATVRHALYDRIWAKKVTAALGLERARYMVSGSAPLDPTLHNFLRVATGTDVLQGYGLTESYASATAQPVYDLTAGNCGSLAPCVEACLVSLPDMEYSVDDKPFPRGELLLRGNNMFREYYKNEEETRSAITEDGWFRTGDVCTIDEKGRFIIIDRRKNVLKLAQGEYISPERLEGVVLSELGYIAQAYVHGDSLQTFLVGIFGVAPDLFAPYASKVLGRTIAPTDLEAVKESLNDDKVRRAVLRDLERVAKKHKFAGYERIRNVSLKVEPFTVENNLLTPTLKLKRPPTVKVYRSLLDQLYEQAVEEQSAPKAKL
What is the function of this protein?
Acyl-CoA ligase involved in the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (By similarity).  The peroxisomal acyl-CoA ligase 891 converts the intermediate MFDHMP-3C into MFDHMP-3C-CoA which impairs its diffusion from the peroxisome (By similarity).  The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC.  5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE.  MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB).  MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP.  The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP).  The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate.  The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C.  After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight.  Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps.  The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process.  Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (By similarity).
What are the official names of this protein?
Acyl-CoA ligase 891, peroxisomal, ACL891.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome matrix.