PharMolix/UniProtQA huggingface dataset:
Protein: RPOA_STAAR
Sequence: MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: FABV_OPITP
Sequence: MIIQPRVRGFVCVTSHPVGCAAHVQEWIDYVKSKGVIAHGPKKVLVIGASTGYGLASRVTAAFGSGAATIGVFYERPSEEGRLATPGWYNSIGFTRAARAAGLYARNFNGDAFSDDIKKQVLDAIKADLGQVDLVIYSLASPRRTHPRTGTVHKSVLKPVGAPYTNKTVDTDTGIVSEITIEPATETEIADTIAVMGGEDWELWMHALRDANLLAPNAQTVAYSYIGPEVTWPVYKNGTIGLAKNDLERAAQALDALLKPTGGRAFIAVNKALVTQASSAIPVVPLYISILYKIMKARGTHERCIEQMQRLFATHMYNGQTPRFDETGRVRIDDLEMAPEVQAAVREIWPTVTTANLVERTDIAGYRSEFLRLFGFGMPGVDYQADVDPHIPMI
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: ID2_PIG
Sequence: MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQSQASRTPLTTLNTDISILSLQASEFPSELMSSDSKALCG
What is the function of this protein?
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity.  Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.  Inhibits skeletal muscle and cardiac myocyte differentiation.  Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.  Restricts the CLOCK and BMAL1 localization to the cytoplasm.  Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity).
What are the official names of this protein?
DNA-binding protein inhibitor ID-2, Inhibitor of DNA binding 2, Inhibitor of differentiation 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYP_ACIBC
Sequence: MRASRFLFATLRETPNDAEVISHQLMLRAGMIRKLASGLYTWLPMGTRVLKKVDAIVREEMNRSGAMEVFMPVTQPASLWEESGRYEQYGPELLRFKDRHDNPFVLGPTHEEVITDLARNELKSYKQLPVNFYQIQTKFRDEIRPRFGVMRSREFIMKDAYSFHATQESLQETYDVMYDTYSRIFTRLGLDFRPVQADTGSIGGSASHEFHVLAASGEDDIAFSTESDYAANVEMAEAVLVGERAAPTQEFKLVETPNQKTIADVCQFLNADPKQSVKALLVQGVADEKGNVPVVALFLRGDHELNEIKAEKHPLVAAPLAFATEEQLQAFGLTAGFTGPQGLVEKGITVIVDRAASVLSDFVAGANEADKHAVGVNWERDAQITEVFDLRNVVEGDPSPDGKGTLQIKRGIEVGHIFQLGTKYSEALGCKVLGEDGKPFTVTMGCYGIGVTRVVAAAIEQNYDDKGIIWPQAIAPFEIAIVPMNAHKSPRTLEAAEALYAELQAQGFDVLLDDRNERPGVKFSDLELMGIPHRIVIGEKGLDAGTFEYKGRRDAEASNLTKEELLAKLAR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_NEIMB
Sequence: MTLAEFWPLCLRRLHDMLPQGQFAQWIAPLTVGEEGGVWVVYGKNQFACNMLKSQFAGKIEAVREELAAGRSAFVFKPGEGVRYEMAAVEGAVEPAEPSLHAVSEGMPVQEVLLDELPSEEPVKPAASKTAADILAERMKNLPHEPRQAAGSASRPESVAVAKARTDVQRDAEEARYEQTNLSPDYTFDTLVEGKGNRLAAAAAQAIAESPGQSYNPFFLYGSTGLGKTHLVQAVGNELLKNRPDAKVRYMHSDDYIRSFMKAVRNNTYDVFKQQYKQYDLLIIDDIQFIKGKDRTMEEFFYLYNHFHNEKKQLILTCDVLPAKIEGMDDRLKSRFSWGLTLELEPPELEMRIAILQKKAEAAGISIEDEAALFIANLIRSNVRELEGAFNRVGASSRFMNRPVIDIDLARTALQDIIAEKHKVITADIIIDAVAKYYRIKISDVLGKKRTRNIARPRQVAMSLTKELTTLSLPSIGDSFGGRDHTTVMHGIRAVAKLREEDPELAQDYEKLLILIQN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAAA_SHIBS
Sequence: MLILISPAKTLDYQSPLTTTRYTLPELLDNSQQLIHEARKLTPPQISTLMRISDKLAGINAARFHDWQPDFTPANARQAILAFKGDVYTGLQAETFSEDDFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENARGKDLYQFWGDIITNKLNEALAAQGDNVVINLASDEYFKSVKPKKLNAEIIKPVFLDEKNGKFKIISFYAKKARGLMSRFIIENRLTKPEQLTGFNSEGYFFDEASSSNGELVFKRYEQR
What are the official names of this protein?
UPF0246 protein YaaA.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: APT_GRABC
Sequence: MDLKKYIRDIPDFPKPGILFHDISTLLADADAWQVTMGRLANRVRVHHPDILAGVESRGFLLAAPLALKLGCGFVMLRKRGKLPGKTIGLDYALEYGTDRLEIQEGAIKPGQRVVIVDDLLATGGTLAAGIDLLHKIGADVAAAATIIELSFLKGRERLNVPCETLVDYQD
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_CHLTR
Sequence: MKRRSVCVGDTVYVLAGNDKGKQGKVLRCLKDKVVVEGINVRVKNIKRSQENPKGKRINIEAPLHISNVRLSIDNQPARLFVKVREKGRELWNKHSDGSSSLYRSVRERKG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CIRBP_XENTR
Sequence: MSCDEGKLFVGGLNFETTEESLEQVFSKYGQVAEVVVVKDRESKRSRGFGFVTFENPEDAKDAMMAMNGKSVDGRQIRVDQAGKSSNDRRGGYRGGSSGGRGFFRGGRGRGGGGDRGYGGSSRFENRSGGYQSSGSRDYYGRSHGSYGDRSGGSYRDSYDSYTTQE
What is the function of this protein?
Cold-inducible mRNA binding protein.  Acts cooperatively with elavl1/elrA to stabilize AU-rich element (ARE)-containing mRNAs by binding to themm and inhibiting their deadenylation.  Essential for embryonic gastrulation and neural development, acting to maintain the expression of a set of adhesion molecules, and cell movement during embryogenesis.  Required for pronephros development (By similarity).
What are the official names of this protein?
Cold-inducible RNA-binding protein, Glycine-rich RNA-binding protein CIRP.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly cytoplasmic in oocytes. Translocates from the nucleus to the cytoplasm upon arginine methylation (By similarity).
Protein: IE61_VZVD
Sequence: MDTILAGGSGTSDASDNTCTICMSTVSDLGKTMPCLHDFCFVCIRAWTSTSVQCPLCRCPVQSILHKIVSDTSYKEYEVHPSDDDGFSEPSFEDSIDILPGDVIDLLPPSPGPSRESIQQPTSRSSREPIQSPNPGPLQSSAREPTAESPSDSQQDSIQPPTRDSSPGVTKTCSTASFLRKVFFKDQPAVRSATPVVYGSIESAQQPRTGGQDYRDRPVSVGINQDPRTMDRLPFRATDRGTEGNARFPCYMQPLLGWLDDQLAELYQPEIVEPTKMLILNYIGIYGRDEAGLKTSLRCLLHDSTGPFVTNMLFLLDRCTDPTRLTMQTWTWKDTAIQLITGPIVRPETTSTGETSRGDERDTRLVNTPQKVRLFSVLPGIKPGSARGAKRRLFHTGRDVKRCLTIDLTSESDSACKGSKTRKVASPQGESNTPSTSGSTSGSLKHLTKKSSAGKAGKGIPNKMKKS
What is the function of this protein?
RING-finger E3 ubiquitin ligase that degrades host SP100, one of the major components of ND10 nuclear bodies, thereby disrupting the organization of these bodies.  Also plays a role in the inhibition of host NF-kappa-B pathway by blocking the SCF(BTRC)-mediated addition of ubiquitin chains to host I-kappa-B-alpha/NFKBIA, thereby interfering with its degradation.
What are the official names of this protein?
E3 ubiquitin-protein ligase IE61, Immediate-early protein 61, IE61, RING-type E3 ubiquitin transferase IE61.
Protein: ALG10_KLULA
Sequence: MISSQIQDGETVGKYSCPTASKRYPSDAAIMSVSETEEKNAVVVEFSRDVEREVVVGIYANVIIWPIATALFCYLAYTLNTTGLPYVFIDEKFHVDQTLRYLRGKWYSWNGKITTPPGLYLLGWLQYHATRFITNWSTLTVLRLTNLIGGVIVWPWVVLRPLYLFNALGFWPVTLMCFPLMASYYFLYYTDIWSTIFIVESLNLALVLPFGETASIWMSALCGLISCLFRQTNIVWNVLIMILVVERRAMIEKNFNTLNFNNYLKLVLHTLENFKSLVLPYAINFGLFLAFLLYNRSITLGDKSNHVAGLHIVQFFYCLMFIAFFSVPVWFSKQVTLSYLIRFVMNPVKYLLELLGIMLIIRYFTVVHPFLLADNRHITFYLFKKLIGRSSLFKYCVMAPIYHFSAYVYLEVMRPSTMIFHPILPIEIKNPIDLPIQLTHISWTALIMCTFMTVVPSPLFEPRYYILPFIFWRLFITMAPEPFWGNPIGKVTGTKRHLSECAWFMIINLITYIIFKRFDIKWESETTVQHIIW
What is the function of this protein?
Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
What are the official names of this protein?
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Alpha-1,2-glucosyltransferase ALG10-A, Alpha-2-glucosyltransferase ALG10, Asparagine-linked glycosylation protein 10, Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10.
What is the protein family that this protein belongs to?
Belongs to the ALG10 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: HIS7_TRIHA
Sequence: MASPLPVRAAALSRDTNETSIQIALSIDGGELPQDADPRLLEASSAHASQTSKSQVISINTGIGFLDHMLHALAKHAGWSMALNCKGDLHIDDHHTAEDCCIAVGTTFAKALGALTGVARFGYAYAPLDEALSRAVVDLSNRPYTVVDLGLKREKLGELSCEMIPHCLQSFAQAARITLHVDCLRGDNDHHRAESAFKALAVAVRWYD
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
Protein: LEU3_RHILO
Sequence: MATKHLFLLPGDGIGPEAMAEVKKLISAMNEKLGSGFATDEGLVGGCAYDAHGAAISDADMAKAMAADAVLFGAVGGPKWDAVPYEVRPEAGLLRLRKDMELFANLRPAICYPALAASSSLKQEVVEGLDILIVRELTGGVYFGEPKQIIDLGNGQKRGIDTQVYDTFEIERISGVAFELARTRKNHVTSMEKRNVMKSGVLWNEVVTQTHKARYADVKLDHMLADAGGMQLVRWPKQFDVIVTDNLFGDMLSDIAAMLTGSIGMLPSASLGAPDVKTKKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFGMVDEADRLEGAIAAVLDQGLRTKDIFSPGMTEVGTVEMGDAIIAKFLG
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRAM_ECOLU
Sequence: MKWIVIDTVIQPTCGISFSAIWGDMKMIIWYQPTIFLTPGSIFTPVKSGIIFKDKEYPITIYNITPFNKDLWSLLKSSQECPPGESEITNKCLHNSCIIKICPYGLK
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
What are the official names of this protein?
Anti-adapter protein IraM.
What is the protein family that this protein belongs to?
Belongs to the IraM/RssC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_SALEP
Sequence: MLEQMGIAAKAASYKLALLSSGEKNRVLEKIADELEAQMESILSANVQDVEQARANGLSEAMLDRLTLTPARLKAIADDVRQVCNLADPVGQVIDGGLLDSGLRMERRRVPLGVVGVIYEARPNVTVDVASLCLKTGNAVILRGGKETYRTNAATVRVIQKALKACGLPEAAVQAIDNPDRSLVNEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDSSADIAPALKIIVNAKTQRPSTCNTVETLLVHQDIAERFLPALSKQMAESGVTLHGDETVMQLHGPAKLVPLKPEKLDNEFLSLDLNVVVVENMDGAIAHIREHGTQHSDAILTSDMHNAARFVNEVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGFGDGTIRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA127_HUMAN
Sequence: MKCPMLRSRLGQESVHCGPMFIQVSRPLPLWRDNRQTPWLLSLRGELVASLEDASLMGLYVDMNATTVTVQSPRQGLLQRWEVSGGQQALPGVSFQPESEVLVHIPKQRLGLVKRGSYIEETLSLRFLRVHQSNIFMVTENKDFVVVSIPAAGVLQVQRCQEVGGTPGTQAFYRVDLSLEFAEMAAPVLWTVESFFQCVGSGTESPASTAALRTTPSPPSPGPETPPAGVPPAASSQVWAAGPAAQEWLSRDLLHRPSDALAKKGLGPFLQTAKPARRGQTSASILPRVVQAQRGPQPPPGEAGIPGHPTPPATLPSEPVEGVQASPWRPRPVLPTHPALTLPVSSDASSPSPPAPRPERPESLLVSGPSVTLTEGLGTVRPEQDPAKSPGSPLLLRGLSSGDVAAPEPIMGEPGQASEEFQPLARPWRATLAAEELVSHRSPGEPQETCSGTEVERPRQTGPGLPREGARGHMDLSSSEPSQDIEGPGLSILPARDATFSTPSVRQPDPSAWLSSGPELTGMPRVRLAAPLAVLPMEPLPPEPVRPAALLTPEASSVGGPDQARYLESAPGWPVGQEEWGVAHTSSPPSTQTLSLWAPTGVLLPSLVELEYPFQAGRGASLQQELTEPTLALSAESHRPPELQDSVEGLSERPSR
What are the official names of this protein?
Uncharacterized protein C1orf127.
Protein: Y460_AQUAE
Sequence: MIGRVFRIFREKGGILKALGLWEWYENLPHKYQKKVKHYYSLKTIKSINFPYKAKHFDTGEVENVLYTKRTFLGTIAQTALLEGDLEFAEWLYNEALKMEGSPYEAHLILNDLVLLAQKQRDLEKVKKYVLQDVELYPEYKEELKSRWGGTLPQIMAFEIYVYLLEREGKIKEALELVEWIKKEGITYPYYDQVKERLLQKLK
What are the official names of this protein?
Uncharacterized protein aq_460.
Protein: TAM_RHILO
Sequence: MADWSAAQYLKFEDERTRPARDLVAQVPVDFPRRVVDIGCGPGNSTELLVQRWPDAQVSGFDTSPDMIEKARVRLPNVSFDLADASTWQPAEPVNVIFANAVFQWLPTHPAVFQRLMGFLAPGGALAVQMPDNLLEPSHQMMRDTAAEMPFADKLKGAARGPLPPVSFYYDLMSPLADRLDIWHTAYNHPLADAEAIVEWVKSTGLKPFLDPLDADERKMFLDSYTAKIAKAYPKTADGKVLLRFPRIFIVAKRAG
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_TRIV2
Sequence: MRHRNRVKKLGKPADQRRALLRALTTELIRHGRITTTLVRAKVVRSEVDKIITLAKDGSLAARRRALGYIYDKQLVHALFEQVSSRYGNRQGGYTRILHTVPRRGDNAEMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: DXS_RHIEC
Sequence: MTHPPKTPLLDQVTYPADLRKLEDRDLPQLAREVRDEMIDAVSRTGGHLGAGLGVVELTIAIHSVFDTPNDRLIFDVGHQCYPHKILTGRRDRIRTLRQENGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAIAADLEKTDRRVIAVIGDGAMSAGMAYEALNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKNIDRAITRAVEHARGYVTGGTMFEEMGFYHIGPIDGHSFDHLLPVLRNVRDNARGPVLIHVVTQKGKGYPPAEAAADKYHGVNKFDVITGAQARVKPNAPSYTSVFAEALVQEAALDDKIVGITAAMPNGTGLDKLAEAFPSRCFDVGIAEQHAVTFAAGLAAEGYKPFAALYSTFLQRAYDQVVHDVAIQGLPVRFPIDRAGFVGADGPTHAGSFDTAFLATLPGFVVMAAADEAELKHMVRTAAAYDAGPISFRYPRGEGVGVDMPARGEILQIGKGRIVKEGTKVALLSFGTRLADCLLASEDLEAAGLSTTVADARFAKPLDHELLRQLARHHEMLITVEEGSVGGFGSQVMQYLSSEGLLDNGLKIRSLVMPDIWMEQAKPEAMNAHAGLDRAGIVSTVFRALRRGVAVGVAG
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: PNP_LISMF
Sequence: MSEKQVFSTEWAGKTLSVEVGQLAKQASGAALIRYGDTVVLTAAVGSKKPRPGDFFPLTVNYEEKMYSVGKVPGGFLKREGRPSDRATLTARLIDRPIRPLFAEGFRNEVQITSTVFSVDQDCSPEMAAMLGSSVALVISDIPFEGPIAGVDVGRIDGKYVINPTIEQAEKSDISLTVAGTYDAINMVEAGAKEVSEEAMLEAIMFGHEEIKRLCEFQQQIIAAVGKEKREIELFVSDPELEAEVKAASEGKMKAAIKTEEKKAREAAIEDVKEEILESYKAKELENEAEILSEVAHILEMIEKDEMRRLISQDKIRPDGRKVNEIRPLSSEVGMLPRVHGSGLFTRGQTQALSVCTLAPLREHQIIDGLGTEEYKRFMHHYNFPQFSVGETGPRRAPGRREIGHGALGERALQYVIPSEEEFPYTIRLVSEVLESNGSSSQASICGSTLAMLDAGVPIKAPVAGIAMGLVKLGDDYTILSDIQGMEDHFGDMDFKVAGTKDGITALQMDIKIDGLSRQILDEALTQAKEGRLHILEHLTSTISAPREELSAYAPKIITLNIKPEKIKDVIGPGGKQINAIIDETGVKIDIEQDGTVYIASQDQAMNRKAIAIIEDIVREVEVGEVYTGKVRRIEKFGAFVELFKGTDGLVHISELAHERVGKVEDILKLGDEVTVKVIEVDQQGRVNLSRKALLEKKEQPEGDKKPQAEKKFYPKTKKPESK
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_HYPNA
Sequence: MKLRPLHDRVVVRRVKEEEKTKGGIIIPDNAKEKPQEGIIVAVGNGAIGDDNERVPLDVKKGDRVLFGKWSGTEVKIDGEDLLIMKESDIMGILDK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK2_PICSI
Sequence: METFLFTSESVNEGHPDKLCDQISDAVLDACLIQDPDSKVACETCTKTNMVMVFGEITTKADIDYEQIVRKTCREIGFISDDVGLDADHCKVLVNIEQQSPDIAQGVHGHFTKRPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTEVRKNGTCPWLRPDGKTQVTIEYRNEGGAMVPERVHTVLISTQHDETVTNDQIAADLKEHVIKPVIPEKYLDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVAAGLARRCLVQVSYAIGVPEPLSVFVDSYGTGSIPDKEILELIKENFDFRPGMITINLDLKRGGNGRFQKTAAYGHFGRDDPDFTWETVKPLKWDKAQA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPHA2_MACFA
Sequence: MELWAARACFVLLWGCALAPATAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQSLARFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEVSESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPMSMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCESSVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGSLAVIGGVAVCVVLLLLLAGAGFFIHRRRKNLRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGTLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEFMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
What is the function of this protein?
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells.  Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway.  May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.  During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues.  Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development.  Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance.  With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).
What are the official names of this protein?
Ephrin type-A receptor 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells. Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells.
Protein: PNCB_ACIET
Sequence: MIITSLLDTDLYKFTMMQVVLHQFPGAQVEYRFKCRNPGVELAPFVSEIRDEIRALCSLQFQDAELAYLRSLRFIKSDFVDFLGLFRLNEKYIRVSALPSGEIDITITGPWLHTILFEIPVLAIVNEVYFRNTQKVPDFPEGRRRLEAKIGQLQQPGLDSLKIADYGTRRRFSRAWHEEVLRVLCVRLGSDDRRGAPGQFAGTSNVLYAMKLGVTPLGTMAHEYLQACQSLGPRLRDSQVFGFEMWAKEYRGDLGIALSDVYGMSAFLRDFDLYFCKLFDGARHDSGDPFAWGERLLQHYRDNRVDPLTKTLIFSDALTVPRIIELYQRFNGRCQLAFGIGTNLTNDLGYEPLQIVIKMTRCNGQPVAKLSDAPGKNMCNDEKYLAYLRQVFEIPSPQ
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.