PharMolix/UniProtQA huggingface dataset:
Protein: TSN12_RAT
Sequence: MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGTLLVIFCVELACGVWTYEQEVMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNYFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQEDLSDLYQEGCGKKMYSFLRGTKQLQVLRFLGISIGVTQILAMILTITLLWALYYDRREPGTDQMLSLKNDASQHLSCHSVELLKPSLSRIFEHTSMANSFNTHFEMEEL
What is the function of this protein?
Regulator of cell surface receptor signal transduction.  Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction.  Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs.  Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1).  Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP.  Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP).  Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity).
What are the official names of this protein?
Tetraspanin-12, Tspan-12, Transmembrane 4 superfamily member 12.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACNR_MYCTU
Sequence: MPKVSEDHLAARRRQILDGARRCFAEYGYDKATVRRLEQAIGMSRGAIFHHFRDKDALFFALAREDTERMAAVASREGLIGVMRDMLAAPDQFDWLATRLEIARKLRNDPDFSRGWAERSAELAAATTDRLRRQKQANRVRDDVPSDVLRCYLDLVLDGLLARLASGEDPQRLAAVLDLVENSVRRS
What is the function of this protein?
Represses the expression of the aconitase gene acn and its own expression, in an iron-responsive manner.  Binds to the inverted repeat element present in the upstream region of acn (Rv1475c)-Rv1474c operon.  Preferentially binds to major groove of the DNA.
What are the official names of this protein?
HTH-type transcriptional repressor Rv1474c.
Protein: EFP_LACLA
Sequence: MVLAKDLKSGMTFLNGEKLLRVMEASHHKPGKGNTIMRMKLKDVRSGSTFDDTYRPEDKFEQAVIETVTAQYLYSMDGIANFMNNETYEQYEIPVEQVKDELLYVLENTDVKIQFYGTEVIGIQLPTTVVLEVTETQPSIKGATVTGSGKPATMETGLVVNVPDFVEAGTKLEINTQTGEYLKRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDAC7_RAT
Sequence: TPGSQPQPMDLRVGQRPTVEPPPEPALLTLQHPQRLHRHLFLAGLQQQQRSAEPMRLSMDPPLPELQGGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPALGSEADG
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C.  During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.  Positively regulates the transcriptional repressor activity of FOXP3.  Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity).  In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity).
What are the official names of this protein?
Histone deacetylase 7, HD7, Histone deacetylase 7A, HD7a.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation (By similarity).
Protein: ASIP_MACNR
Sequence: MDVTRLLLATLLVFLCFFTACSHPPPGEKLRDDRSLRSNSSVNLLDFPSVSIVALNKNSKQISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: KLOT_HUMAN
Sequence: MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLERFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK
What is the function of this protein?
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
What are the official names of this protein?
Klotho.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide. SUBCELLULAR LOCATION: [Isoform 2]: Secreted. SUBCELLULAR LOCATION: [Klotho peptide]: Secreted.
Protein: TACHY_AGRIP
Sequence: MGAPRTCLIFITIQLVSLAYAQEVSKRVPQGFLGMRGKKYFDEEGIEQFYKRKPQFFVGVKGKKSLQDILEAPEEYYKRAPMGFMGMRGKKDLGDSQSTELFPKRDGSLIGKIDYSSKEENADPDFPILNELLLQYLSQLDAPRNTYMQSSESMEPEQSNDLDKRAANFNQFYGVRGKKSINNKRPYDLTFRGKFIGVRGKKDLKNSNAHEIKFLVDQNGPLPKRKAQMGFFGMRGKKWTDEPSLEMDMPN
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
What are the official names of this protein?
Tachykinins.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LF3_EBVB9
Sequence: MKRVARGPCLAPGSGLGAHPHPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPRAPGPEPRTRLQPATPRRSGAADPADPVGHPAAPELQGWVLRPKGTGGDFRGIGVTINWLNLHHVYVVFHAAYRLEGQVVIGSEILETRVPLKQGALLPLLF
What are the official names of this protein?
Uncharacterized protein LF3.
What is the protein family that this protein belongs to?
Belongs to the epstein-barr virus LF3 family.
Protein: Y4299_BACMK
Sequence: MNGIRDVVREEQPRERLLLEGAGSLSNRELLAVLLRTGSKEETVLTLSDNILHHFDGLRMLKDATLEEMMSIHGVGIAKASQLMAAFELGRRMVRLEYQNRYSIRSPEDCASYMMEEMRFLQQEHFVCLYLNTKNQVIHRQTIFIGSLNTSIVHPREVFKEAFRRAAASIICLHNHPSGDPAPSREDIEVTKRLVECGRIIGIEVLDHIIIGDHKFVSLKEKGHI
What are the official names of this protein?
UPF0758 protein BcerKBAB4_4299.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: TAL_TERTT
Sequence: MTNKLEQLKQYSDVVADTGDIEAIARYKPLDATTNPSLLYKAAQMEQYAPLVQDALSSTDSIEAACDKIAVAIGCEILKIVPGRVSTEVDARLSFNTNASIEKAKHLIGLYEEAGISKERVLIKLASTWEGIRAAEVLEKEGINCNLTLLFSFSQAAACADAGAFLISPFVGRILDWYKANTDQKEYAPMEDPGVVSVTRIYNYYKQHGYNTVVMGASFRNTGELEALAGCDRLTISPQLLGELEADTGELKRVLTPENSGEAIAKLIEDEAAFRFSNNEDAMATEKLSQGIRGFVADQVNLENFLKSKA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_OLEA2
Sequence: MQIITSPEELQRLCLDWRCGGVKTALVPTMGYYHAGHESLMAYARERADKVVVSLFVNPAQFAPGEDLAAYPRDLSGDAEVAQRAGADVLFTPQPEAMYPQGFDTWVEIPGLSSGLCGADRPGHFRGVCTVVMKLMLLTLPRLAVFGEKDWQQLAVLRRMAKDMHLPVTIDGCPIVRETDGLAMSSRNVYLTPEERRQAPALYQGLIRARDMVAGGERDTAVLRAAVKEYWKQHLPEGREDYLEIVHPDTLQPLERVGGMATCAAAVRLGRARLIDNLALI
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVSSA_CHICK
Sequence: MDQRLAQLVEELTTAGEPQLEPGRMKELKKICRSSEEHLSHAYHLLLTRLHEEHAEMRFSAFQIVQELFSRSHLFRTLLVSNFQEFLELTVGTDHEQPLPPPREVAQKLRKAAIAAVQGWHEKYGEAYKKLSLGYHYLKQNKKVDFQDVHARTVAERKREEEKQKRLDNVYKEKAKRAEKEMAEMSQEVAGTLTEMENCFRLLLPDPFDFTVNSTGLEPNEQTSADEDRSASSLPTYVGCVDDEQPCCSKDILPISQCVRTDQNEELADKQKKPEQDLLDGDTCSEVESGVPVLGDDDYETFVRNHGLISHKYALDLELSTADIKVHENEDNTAVINSVADAHKLVRNKFLPSVQSWIQLFTRAGINDDRLRCAIDLKNRLEAALRKYKEMNISFKERKRKVMKASDDGDDDDDDEDDFVEVPEKEGYEPHIPDHLRKEYGLENCPKKDESVKKDSCSLTKTKQKNEDELDPTCAAATLKLIRDKLPNESATTEPAALEEPDSKRRKLEEERAKAPLMPFGLDLHYWGQDQPSAGKILKFTSEHRFWAPSEVEEEVENKEITEMLKTRYITFAGKFEPVKHKCRAPMPDGSLCERQDRIKCPFHGKIIPRDECGVPINAEDRAREEKMRFEKQATQPETEWRDPEFMREVEAATGVDLGSSKTNGKGGKKKGKKKYPNLTDLKQQANTARSRLEKIVFNKGAVKRVVKAMNQMDQRKHEKFANQFNYALN
What is the function of this protein?
Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.  Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (By similarity).
What are the official names of this protein?
UV-stimulated scaffold protein A.
What is the protein family that this protein belongs to?
Belongs to the UVSSA family.
What are the subcellular locations of this protein?
Chromosome. Note=Accumulates at UV DNA damage sites.
Protein: EST1F_MOUSE
Sequence: MFLSTLFLVSLATCVICGNPSSPPVVDTAHGKVLGKHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDAARGQAVNDLITNRKEKIHLEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLGGASSFDGRALSAYENVVVVAIQYRLSIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITEQIAVTAGCKTTTSAVIVHCMRQKTEEELLEIMHKLNLYKLSLQGDTKNSDQFVTSVLDGVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQFASMTGIPEDIIPVAVEKYTKGSDDPDQIREGVLDAMGDVAFGVPSVIVSRGHRDTGAPTYMYEYQYYPSFSSPQRPKNVVGDHADDVYSVFGAPILREGASEEEINLSKMVMKFWANFARNGNPNGKGLPHWPKYDQKEGYLHIGGTTQQAQRLKEEEVTFWTQSLAKKQPQPYHNEL
What is the function of this protein?
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.  Hydrolyzes retinyl esters (By similarity).  Hydrolyzes p-nitrophenyl butyrate (PNPB), triacylglycerol and monoacylglycerol.  Shows higher activity against PNPB, a short-chain fatty acid ester, than against triolein, a long-chain fatty acid ester.  Shows no detectable activity against diacylglycerol, cholesterol ester or phospholipids.  May play a role in adipocyte lipolysis.
What are the official names of this protein?
Carboxylesterase 1F, Carboxylic ester hydrolase, Triacylglycerol hydrolase 2, TGH-2.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Lipid droplet. Cytoplasm, cytosol. Endoplasmic reticulum. Microsome.
Protein: GPDA_SALAR
Sequence: MNQSNASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIATLEHDRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFSDVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDETFADDLQQLLHCGKSFRVYINADFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLTEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVKGAQDKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKEELSRH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_TOLAT
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTGAIKAAGGTIHRLEDWGRRQLAYPIDKLHKAHYVLMNVEAEQSVIDELENNFRFNDAVIRNMIMRTKHAVTEASPMLKAREERPRREDVREEAEEAAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: LEUC_NAUPA
Sequence: MPMTITEKIFAEHIGREVKPGEIIMCDVDMTIGNDITTPISIRAFNESGAEKLAKPDNFAIVLDHFIPPKDIASANQAKINRDFAYKHDLKNFFDEKDMGIEHRLLPEKGLVIPGDVIIGADSHTCTHGALGAFSTGMGSTDIAFCMITGKSWFKIPESIKVVFKGERGEHVYGKDLILELIRRIGVDGALYKALEFTGEVIENLPMDDRMSLCNMAIEAGAKNGIVAYDKITEAFLEEVKKYNPLRSEPKIHYSDPDANYSQVIEIDVNKLEPLVAYPFLPSNGKPISQAVKDDIEIDQVYIGSCTNGTLSDLRIAAEILKGKRVHRRVRLIVTPATQRIYKQAEHEGILDILIDAGAVVANPTCGACLGGYMGILGDGERAVATTNRNFRGRMGSRSSEVYLSNSAVAAASAIAGKIADPRDL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: KAZRN_RAT
Sequence: MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGGPGSGPGAATSASAAAVTVADSAVATMENHQHGAQVLLREEVVQLQEEVHLLRQMKEMLAKDLEESQGGKCSEVLSATELRVQLVQKEQELARAREALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHAAALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKSLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRHSLSLSEGEEQMDRLQHVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACAENVKSGKVLLSLSDEDLELGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAADLDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNTDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMSTVFHPANSTGIRESERFGTPPGRASSITRAGKEDGSSNSKYRTGRLPLGKIGRGFSSKEPDYYDDYGSLENEDCGDDDLQGRPEQCRLEEYSSLEVTNV
What is the function of this protein?
Component of the cornified envelope of keratinocytes.  May be involved in the interplay between adherens junctions and desmosomes.  The function in the nucleus is not known (By similarity).
What are the official names of this protein?
Kazrin.
What is the protein family that this protein belongs to?
Belongs to the kazrin family.
What are the subcellular locations of this protein?
Cell junction. Nucleus. Cytoplasm, cytoskeleton.
Protein: RECF_SHEB9
Sequence: MSLTRLNIEAFRNIQSAQLIPAPGINLIYGQNGSGKTSILEAIYFLGMGRSFRSHLSQRVINNDDDKLTLFATLNLARGDSKIGLRRFRSGETEVRIDGEKVKRLSTLAETLPIQVITPESFSLLFEGPKSRRQFIDWGAFHADPQFYGAWTNVRRVLKQRNQLLRNGSAYSNIQFWDQEFVRYAEQVTEIRNHYVDSLNELLKGIIGEFLPSVDVKVSFTRGWDSKTDFAELLENQYSRDLATGHTVSGPHKADLRLRVGTLPAQDALSRGQLKLLVCALRIAQGKLLKQQIDKHSIYLVDDLPSELDAQHRQLLLKQLTDTGAQVFVTAIDPAAIVDSLHTPPSRMFHVEQGRVTVIE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOR3A_MOUSE
Sequence: MFLGALWLLLLLPLRPPGAQGQEADEPTPWPSVKGLKEQLRKAGALSKRYWELFSCTLWPDHCEDQETPVPPLGWSLPLWGRRSLDVLTAWLCRFQDCCSGGGDCRISNNLTGLESDLRVRLHGQHLASKLVLRAVKGYLEMPQVGKALALSFHGWSGTGKNFLARILMDNLYRDGMRSDCVKMFISTFHFPHPKYVDTYKEELQRQMQETQWRCHQSTFVFDEAEKLHPGLLELLEPYLEPRSPEARGVEAPRAIFLFLSNLGGSVINEVVLSLLKAGWSREEITTQHLEVPLQAEIMEAADSSFGSSGLLKKHLIDHFIPFLPLEYCHVRLCVRDAFLGQDLPYTEETLDEIAKMMTYVPEEERLFSSQGCKSISQRINLFLP
What are the official names of this protein?
Torsin-3A, ATP-dependent interferon-responsive protein, Torsin family 3 member A.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. Torsin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum lumen.
Protein: GTAP_DICDI
Sequence: MNSYQIQNQPYQQIQNTHPSFQQVQPMQVPHLQQQQQHQTMIAQQQHTPPQQHTPPQMNMIQQHTQPMLSQPQISLQMQPPSPILASQQQQQHMQSSPILASSNLTNSNNASQTTLPIITSKLLLKKEPIDQEVVNSTHKTTTTNNKPPKQSKRKEKERLEEEKQTVAQQQQYQPPFIPLASNESNSDNPFKGSHAYGVSTTPYGNSQFNNNNNNNNNNNNNNNNSNNNSNNNNGNNNINNNNNNSNNNNNNNSNNNNNNSNNNNGNNNNNNNNNNNNNNNNHNTNNNNSNSNNNNNNGYQQDKKDDYSMMIWSEVGRKINILIRTTSKATKGTPISTQEIAEAIGASNGVTADLVELIKSINDPTYVRKLPPSSISNTPTMGSQSGGMVYNSSPMLSPSTMSPILQHGNYQMGGDMYFGGNNQFSGDKQSALNNVKNSKGGNTNNSGGGSSSGGTNDTQAKKPARRRKMRYGGTELSCHTCGVTNTPEWRRGPNGAKTLCNACGLAWAKSVKSEKQKELLANSTGVNITEPKKAQKRKKESSDNNNNNNNSSDSNKVLKSDDGSNNTNLTNDDDNGYPSSPNSSNSTSPSSHNINNNNNNNNNNNNNNNNNNNNNNNNNNNNIGNNNNNNINNNNTTNSITTPTTTPFPTTIPAMQIVSQLPVMVPQTQQQPHMSGNIISFQALHQNSGYQHYK
What are the official names of this protein?
GATA zinc finger domain-containing protein 16.
Protein: FIXC_RHIME
Sequence: MTKEKFDAIVVGAGMSGNAAAYAMASRGLKVLQLERGEYPGSKNVQGAIMYANMLEAIIPDFRNDAPLERHLVEQRFWIMDDTSHTGMHYRSDDFNEVTPNRYTIIRAQFDKWLSRKVCEAGGTVLCETTATGLEWDSAGKAIGVRTDRAGDVVLADVVVLAEGVNGLLGTRAGLREMPKSKNVALAVKELHFLPEEVIAERFGLTGDEGCVIEAGGTISRGMAGLGFLYTNKESISLGIGCLISNFAETMERPYALLDAFKRHPSIQPLIAGSEVKEYAAHLIPEGGFNAIPRLCGNGWVVVGDAAQLNNAVHREGSNLAMASGRMAGEAISIIKSRGGVMDKASLSLYKTMLDKSFVVEDLSKQKDMPSLLHTNSPNFFTTYPQLISHAAQNFVRVDGTPKIEREIATTAAFLRARSRWGLVSDAVRLASAWR
What is the function of this protein?
Could be required for the formation of a functional nitrogenase Fe protein.  Probably accepts electrons from FixA/FixB and reduces a quinone.
What are the official names of this protein?
Protein FixC.
What is the protein family that this protein belongs to?
Belongs to the ETF-QO/FixC family.
Protein: FAR4_STRNA
Sequence: GVDSSFLRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-4, FMRFa-4.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MFNA_METMA
Sequence: MNEQGLSEREIFSYLENAKSEDTDYYRVFSSMCTRPHKIAIEANRLFIEANLGDLGLFAGAHKLEQEVVRMLGNLLHASSIDVPSGGLCQSSVCGYLTTGGTESNIQAVRGMKNLVTAGKKEFKGTPNIVIPASAHFSFDKVADMMGIEVRRASLDSEFRVDMASVEKLINENTIGLVGIAGNTEFGQIDPIDKLSEVALENELFLHVDAAFGGFVIPFLEKPQPFDFKVPGVTSIAIDPHKMGLSTIPSGALLFRSPSFLDSLKVSTPYLTTKSQFTLTGTRSGASAAATCAVMKYLGYEGYRKNVQYCMELTSKIVEEARKLGFEPLIEPVMNVVALKVPNPDLVRERLLKKFGWNVSITRTPRALRLVLMPHNSPEDIELFLEDLKKVTAEIKSP
What is the function of this protein?
Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis.  Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
What are the official names of this protein?
Probable L-tyrosine/L-aspartate decarboxylase, TDC/ADC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. MfnA subfamily.
Protein: NUOA_BURP1
Sequence: MNLAAYYPVLLFLLVGTGLGIALVSIGKILGPNKPDSEKNAPYECGFEAFEDARMKFDVRYYLVAILFIIFDLETAFLFPWGVALREIGWPGFIAMMIFLLEFLLGFAYIWKKGGLDWE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSP14_CHLRE
Sequence: MDSQARIQANLRHIQAFEAKPNPKALPETAVTRGFEKVAFPKLVRELTCDNAVVRKKSLLAARELLSSPVNHVQCVAAGATPAIVALLQDQTDDETRYYAAGTLKLLAAKEVGARDLAQHSGLDALAAALEDPSEGVRDEAYGALIEAARFDSTRRALEACGSGAVLPRLMELALLEAQGGAAGRAQQGLVLLFTCTQARHNAGILSQLVDVAQAIPHLAGLLKPELPMPVRHAAAELLGALATREDAKIQAVQVGAVPLLLLAASPSVPVPFATSAVAALGAITIRREGKYAALESPGGLAGLVSVLDPCHEQLCINAMTAVSNVAEAPEARAILVASGAGPKLQHIFETATVEVVKRAAAQAIRQCRFKHLPYEVLPGAPPINEE
What are the official names of this protein?
Radial spoke protein 14, Flagellar-associated protein 132.
What is the protein family that this protein belongs to?
Belongs to the flagellar radial spoke RSP14 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Radial spoke.
Protein: HEM3_PROM0
Sequence: MTNFKLKIASRRSKLAMVQTLWVKDQLERNIPNLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVHSLKDLPTNLPNGLKLGCITKREDPADALVVNKKNDCYKLETLPEGSIVGTSSLRRLAQLRNKYPHLIFKDIRGNVITRIEKLDAGEFDCIILAAAGLKRLGFESRIHQIIPSEISLHAVGQGALGIECKSDDKKVLEIINILEDKPTSQRCLAERAFLRELEGGCQVPIGVNSNIQNEKLCLTGMVASLDGERLIKDQHIGNINDPEEIGKELAKKLKQQGAEEILSEIFEKFREK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.