PharMolix/UniProtQA huggingface dataset:
Protein: FMT_FRAT1
Sequence: MKKLNIIFAGTPDISAQVLKDLYKSQHNIQAVLTQPDRAKGRGKKVQFSPVKEVALANHTPVFQPLSFKKNPEVLEQIKQLKPDVIVVIAYGIIVPQEFLDIPRYGCLNIHVSLLPKWRGAAPIQRAIQAGDTKTGVCIMQMDAGLDTGDILNTLEIEIQETDTSQTLHDKFAKLSIKPLLETLEKIEIIKPEPQQGEPTYAHKITKQEGLIDFTKSAWQISCHIRAFTPWPGAYFILDDEAIKVGEFEILYQNTDNRKAGTIIDIYRSGFDIATSDKIIRFRQLQFPNKKMLNIVDILNGKDLDKYIGYKLG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: BETA_BRUME
Sequence: MEADFVIIGSGSAGSAMAYRLSEDGRYSVIVIEYGVPDVGPLIQMPAALSFPMNMETYDWGFSSEPEPHIRGRSLVTPRGKVLGGSSSINGMVYVRGHACDFDHWSQSGARGWAYADVLPYFKRMENSQGGQEGWRGTNGPLYVQRGKRDNPLFHAFVEAGHQAGFEVTDDYNGEKQEGFGPMEQTIHNGRRWSAANAYLKPALKRPNVKLVKGFARKIVLEGKRAVGVEIEAGRTFSTIRARREVIIAASSINSPKLLMLSGIGPAAHLKEHGIDLVADRPGVGQNLQDHLEVYIQQECTQPITLYSKLNLFSKARIGVEWLLFKTGDGATNHFESAAFVRSKAGVEYPDIQYHFLPVAIRYDGKAAAQSHGFQAHVGPMRSKSRGSVTLRSANPREKPVIKFNYMSHEDDWADFRHCVRLTREIFGQAAFDPYRGAEIQPGAHVQTDDEIDNFIREHVESAFHPCGTCKMGAVDDPMAVVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMVGEKASGHILGRTPLARSNQEPWINPRWQVSDR
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: LFTR_SHEB2
Sequence: MKSLSFLNHEFEAFPSPELALTDPNGLLAIGGDLRPERLLSAYYNGIFPWFNSDDPILWWSPDPRAVFIPGEIHISTSLRKYLKKQPWRITINHAFTDVMAGCAQPREKQSGTWITQEIQMAYRELHYTGHAHSIEVWEGERLIGGLYGLAIGQVFCGESMFHRKTNASKAAVAALQQHLLKMGFKLIDAQVMNSHLESLGAKAIKRIDFITLLSELRNNPVDPATWTTKEVILELE
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZO3_HUMAN
Sequence: MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL
What is the function of this protein?
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888).  The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells.  Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888).  Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630).  With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).  Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).
What are the official names of this protein?
Tight junction protein ZO-3, Tight junction protein 3, Zona occludens protein 3, Zonula occludens protein 3.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus. Note=Exhibits predominant nuclear expression in proliferating cells but is exclusively junctionally expressed after confluence is reached (PubMed:23608536). Shows an epithelial-specific tight junction localization in a TJP1/TJP2- dependent fashion (By similarity).
Protein: MED17_ASPOR
Sequence: MSDSFNLPLRPLTEKRERPDPLPVEIAQINAQYGSFRDVTEDSLRAKIEADKNKDPWFDKEENDNASADEDTTERLDQLYKRRAAITQFALQAHMEAMFALDFVSLLLSKHTPRQAEMSMSAYLKQVAPLGSLNSEIVNPPPKPESAARDTKNVSRGWRLQNFNSAASKLLDSATRLEAEVASETRYWDEVLAVKEKGWKVSRLPRERQALGVQYGFLEATPIFRDRGLAALRRTNDGSLILDKGLIPLKARTVRVRVRSRGQITGCSKNQPASDNTESIESRILQARDTVYEEELFHELVREARILGSQGVTTRQNLVQFPVSEEQEVLLDLIDSDQISPENDVVSSNEHAVVADALAHAIRILLAYAHRQNLRRRTQLPTPLTPKRRQTPEYQLLRPVMAYLQHSSHVRWLESLLNDINQILKSAGITCDFTATPFSSLSLRRTISGLPKVEALVQEFLLPYESTFSAQLVTPQSSFRVKVRTNVTTPPLGTHYEISVNMPQYPDVRPPNRIGLQDEAASILTHFVLLDILTAITHAKGSSVKGIKQETGHLLTWQAAYPHNGELLALSSTGQHKKMKVSLSRHELTVRVYSIRGIDGFGKPAVDKTPAMRSQTWKCDGTPDQPNLMDFIAEVSKE
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 17, Mediator complex subunit 17.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 17 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RAB6A_CHICK
Sequence: MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDKSREDMIDIKLEKPQEQPVSEGGCSC
What is the function of this protein?
Protein transport.  Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).  Involved in COPI-independent retrograde transport from the Golgi to the ER.
What are the official names of this protein?
Ras-related protein Rab-6A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor.
Protein: K2C71_FELCA
Sequence: MNRQFTCKSGAAAKGGFSGCSAVLSGGSSSSYRAGGKGLSGGFGSRSLYSLGGIRNISLNMASGSGKSGYGFGRGRASGFAGSMFGSVALGPVCPTVCPPGGIHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRSVRDVVEDYKKKYEEEINRRTAAENEFVLLKKDVDAAYANKEELQAKVDSMDQEIKFFKCLYEAEIAQIQSHISDMSVILSMDNNRDLNLDSIIDEVRAQYEEIALKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRSEIENVKKQASNLETAIADAEQRGDSALKDARAKLDELESALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVSISIISSTSGSSGYGLRPSSVSGGYVANSSSCISGVCSVRGGEGRSRGSTSDYKDTLGKGSSQSASSKKASR
What is the function of this protein?
Plays a central role in hair formation.  Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.
What are the official names of this protein?
Keratin, type II cytoskeletal 71, Cytokeratin-71, CK-71, Keratin-71, K71.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SSTT_YERPA
Sequence: MEKTQSVFIRFIVNGSLVKQILIGLVAGIVLALVSTPAAIAVGLLGSLFVGALKAVAPVLVLMLVIASIANHKKGQKTSIRPILFLYVLGTFSAALVAVVVSFIYPSTLILVAESADITPPSGIVEVLHGLLNSIIANPIHALLNANYIGILAWAVGLGIALRHAADTTKALINDMSDAVTLVVRVVIRFAPLGIFGLVASTIAATGFGALQLYAQLLVVLIGCMLLVALVVNPLIVYWKIRRNPYPLVFACLRESGVTAFFTRSSAANIPVNMEMCKKMNLNEDTYSISIPLGATINMAGAAITITVLTLAAVHTLGITVDLPTALLLSVVAAICACGASGVAGGSLLLIPLACSMFGIPNDVAMQVVGVGFIIGVLQDSAETALNSSTDVLFTAAVCQAEDAKLANPDPLAAGKSV
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS21_STRP8
Sequence: MSKTVVRKNESLDDALRRFKRSVTKAGTLQESRKREFYEKPSVKRKRKSEAARKRKKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RHNO1_MOUSE
Sequence: MPPKKRRRQSQKAQLLFHQQPLEGPKHHYESCQQPITHTVQVPSKPIDQSTVTSWVSPQFDRAAESRFLIHWKPHRDQARRPTRRSTCKFPRLTFESPQSSSSETLLLSNRVQPQNSEKDPPRRPLVPLFSPQSCGELSVHVPHSLPHVFAPPDIQTPDSSVRDDPISPDQKENSFPSCILGPGTPSSPEPGPVLVKDTPEEKYGIKVTWRRRRHLFAYLKEKGKLDGSQFLVKI
What is the function of this protein?
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase.  Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner.  Required for the progression of the G1 to S phase transition.  Plays a role in the stimulation of CHEK1 phosphorylation (By similarity).
What are the official names of this protein?
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
Protein: PELO_METHJ
Sequence: MKAEIEELQRSFGEIRLFPENSDDLWHLHNLITPGSLVYATTLRSVEGSQDKIRPEKQEKRPVRLGIRVEDVEFHEYSIRLRVFGTIESGVDIGSHHTLNLEPGYEISVIKSWSGSDLERIDRAIKGSTSEAIHILTVEEGEAELYRVQSYGPKQVWSLAAGSGKTAEVSSREEFSEAVVSQVSQLTGPLVIAGPGFVKEEIIAKFKRKNPSRSAPLVIGDTRAGGRRAVQEVIGQGILEKLNGDLQLAREVTCLDELMRRIGKDEPVAYGIDAVRDATGCGAVQTLMVVDTLLRDPDAADLIRQAEAMRSEVVIFSSRFEPGERLAGLGGIAALLRYSIA
What is the function of this protein?
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA.  May play a role in the release non-functional ribosomes and degradation of damaged mRNAs.  Has endoribonuclease activity.
What are the official names of this protein?
Protein pelota homolog.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB1_ASHGO
Sequence: MVQISEVKDQVPGSSAGARTAAHTHIKGLGLDEFGAAKQVEGGFVGQVEAREACGVIVDLIKAKRMSGRAILLAGGPSTGKTALALAITQELGPKVPFCPLVGSELFSVEVKKTETLMENFRRAIGLRIKEVKEVYEGEVTELTPEEAENPLGGYGKTISHVIVGLKSAKGTKTLRLDPTIYESIQREKVSVGDVIYIESNSGAVKRVGRSDAYATEFDLEAEEYVPLPKGEVHKKKEIIQDVTLHDLDVANARPQGGQDVISMMGQLMKPKKTEITEKLRHEVNKVVAKYIDQGVAELVPGVLFIDEVNMLDIEIFTFLNRALELEIAPVVVLASNRGMTTVRGTEDVVSAHGIPPDLIDRLLIVRTLPYTQDEIRVIIEKRSKVENLQLEQAALDLLAAMGSDMSLRYALQLLTPAGILAATAGRTEILLSDIEEAKMLFLDAKRSTKILESNSNYL
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 1.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: C71B3_ARATH
Sequence: MSILLYFFFLPVILSLIFMKKFKDSKRNLPPSPPKLPIIGNLHQLRGLFHRCLHDLSKKHGPVLLLRLGFIDMVVISSKEAAEEVLKVHDLECCTRPKTNASSKFSRDGKDIAFAPYGEVSRELRKLSLINFFSTQKVRSFRYIREEENDLMVKKLKESAKKKNTVDLSQTLFYLVGSIIFRATFGQRLDQNKHVNKEKIEELMFEVQKVGSLSSSDIFPAGVGWFMDFVSGRHKTLHKVFVEVDTLLNHVIDGHLKNPEDKTNQDRPDIIDSILETIYKQEQDESFKLTIDHLKGIIQNIYLAGVDTSAITMIWAMAELVKNPRVMKKAQEEIRTCIGIKQKERIEEEDVDKLQYLKLVIKETLRLHPPAPLLLPRETMADIKIQGYDIPRKTILLVNAWSIGRNPELWENPEEFNPERFIDCPMDYKGNSFEMLPFGSGRKICPGIAFGIATVELGLLNLLYYFDWRLAEEDKDIDMEEAGDATIVKKVPLELVPIIHH
What are the official names of this protein?
Cytochrome P450 71B3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: COWN_RHOPS
Sequence: MSGSFDRYVSFKNCDWKVRSERVMARLQRHIDAAENPFWAYFAQKRTELREKQGLDDLRVLHNYLPTLRELLEDNGDLETLAMLEELEVNLM
What is the function of this protein?
Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO).  Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.
What are the official names of this protein?
N(2)-fixation sustaining protein CowN, CO weal-nitrogenase.
What is the protein family that this protein belongs to?
Belongs to the CowN family.
Protein: VF157_IIV3
Sequence: MNPTSADFVIPPALETAKPFGETEMYRILCDMEKIVPTKHNLNRVKNMSPFWKGDERSYNWFLDFVKSEWGEWIERYARGSHSLSPVTRKNGSPFQMVQAELWSLIHKPTWISSGFISPTCAVCMTNPVWVDFVWSCKHISTCIKCLKMLSRGSNGFKCPICRCQQRVRNY
What are the official names of this protein?
Putative RING finger protein 027R.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 157L family.
Protein: Y1350_PROMM
Sequence: MASLPCIPSNFKPGSPPRGLPLACKAFGAGASLAAQERWLMPWRDGGLGFSLLLVLAGTRTAEVEGISAAGATSAARRFTAVADAELLLKGPDRPRLCSLPPLPAGISPALISYVAARWIGVDPLVAAVGLTLSPPFPHLRLEVPGMGPAACLSTGEAMGLSRVHALWQRGFCLGRGLRRPLVLAECVPGGTTTAQAVLTGLGLQVADLISGSARQAPMILKQELVDRGLSKAALGFNPPPQRVIAALGDPFQPVAVGLLLGAREAGQPVMLGGGSQMVAVLALALAAMEPSHRQDMVDGIVLGTTSWLAEEAKRSDGRPGALECLIDCVGEFFGVRLLGLATGLRFNNSQHRALQDYELGYVKEGVGAGALALLAQLQGASCEQLLEACDQAMNQLLGTSYS
What are the official names of this protein?
UPF0284 protein PMT_1350.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: PXPA_SALPK
Sequence: MNIDLNADLGEGCASDSELLTLVSSANIASGFHAGDAQTMLTCVREALKNGVAIGAHPSFPDRDNFGRTAMVLPPETVYAQTLYQIGALGAIVQAQGGVMRHVKPHGMLYNQAAKDPRLAQAIAKAVHDYDPSLILVGLAGSELIRAGERCRLVTRQEVFADRGYQADGSLVPRMQPGALIHDEEQALAQTLDMVQAGRVKSVTGVWTTVTAQTVCIHGDGEYALAFARRLRAAFNARNIHVIA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: ASIP_MACAS
Sequence: MDVTRLLLATLLVFLCFFTAYSHPPPEEKLRDDRSLRSNSSVNLLDFPSVSIVALNKKSKQTSRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR7_CORU7
Sequence: MRPELSDYEHISAGKVREIYEIDAEHLLMVVTDRISAYDFVLDTDIPDKGRVLTAMSAYFFEQIDFPNHLAGPLDDERIPEEVLGRAMVCRKLDMVPFECVARGYLTGSGLKEYEATGAVCGVKLPEGLVEASKLDEPIFTPATKAEIGDHDENVGFDVVVKDLGEDLAERLRTATLEIYSQAAKMAEEKGLILADTKFEFGLDKEGNLVLADEVLTPDSSRYWPAEGYEEGKVQPSFDKQFVRNWLTGPKSGWDKNDGSQPPELPGSVVEATRARYVEAYERISGKRFADWIGSCV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: LPXK_RUTMC
Sequence: MNLNIRGIINYSLLPISGIFYLVSVFRKWLYRVNFFKVQKFKYPVIVVGNITVGGTGKTPIVIALAQYFKQQGKQVGIVSRGYGGAHHQGSLLVNKDTNVYLSGDEPLLIALQTDLPVMINKNRAKAVKDLINQCQVDLIISDDGLQHYKMDRDVEIVVIDGIKRFGNGFFLPLGPLRESITRLKSVDFVINNAGLCAGEFSVKLTLKMFVNVKTGEEKSLNYFKGKYCHGVAGIGHPERFFNALIRLGINLEHHIFADHYIYQQSDLVFEDNHPILMTAKDCVKCTQFENDQMWYLQVEADLSDDFLKKLDAKL
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: LGT_CLONN
Sequence: MNPVAFEIFGLEIRWYGILICMGIILAYGLAYKRSKIYNIDFDKLTDVFIVALPFSILCARLYYVIFNWSYYGANPSHILYIREGGLAIHGGLIGAVISGYLMSRYRKLNFLDLIDTVAPCFILAQAIGRWGNFFNSEAHGGIVSYEFISHFPKFIQNGMYIDGFYYHPTFLYESIWNIVVLIILLLITRKHLAKGSIFYLYLIFYSLGRFFIEGLRTDSLMLGSLRMAQVISLVFIILGIILIIKSNIKNKSTFKQ
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURG_SHIDS
Sequence: MSGQGKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEADLVPKHGIEIDFIRISGLRGKGIKALIAAPLRIFNAWRQARAIMKAYKPDVVLGMGGYVSGPGGLAAWSLGIPVVLHEQNGIAGLTNKWLAKIATKVMQAFPGAFPNAEVVGNPVRTDVLALPLPQQRLAGREGPVRVLVVGGSQGARILNQTMPQVAAKLGDSVTIWHQSGKSSQQSVEQAYAEAGQPQHKVTEFIDDMAAAYAWADVVVCRSGALTVSEIAAAGLPALFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQLSVDAVANTLAGWSRETLLTMAERARAASIPDATERVANEVSRAARA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YL66_SCHPO
Sequence: MKLNVCFRICNFLFQFSLEFFSISSLHSISSLHSISLSLSLFFLVAILYNIYIYLFRSKKKPKRILFAIPPLCPLCSPCFFFGTSSMLL
What are the official names of this protein?
Putative uncharacterized transmembrane protein PB15E9.06.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BUB1_YEAST
Sequence: MNLDLGSTVRGYESDKDTFPQSKGVSSSQKEQHSQLNQTKIAYEQRLLNDLEDMDDPLDLFLDYMIWISTSYIEVDSESGQEVLRSTMERCLIYIQDMETYRNDPRFLKIWIWYINLFLSNNFHESENTFKYMFNKGIGTKLSLFYEEFSKLLENAQFFLEAKVLLELGAENNCRPYNRLLRSLSNYEDRLREMNIVENQNSVPDSRERLKGRLIYRTAPFFIRKFLTSSLMTDDKENRANLNSNVGVGKSAPNVYQDSIVVADFKSETERLNLNSSKQPSNQRLKNGNKKTSIYADQKQSNNPVYKLINTPGRKPERIVFNFNLIYPENDEEFNTEEILAMIKGLYKVQRRGKKHTEDYTSDKNRKKRKLDVLVERRQDLPSSQPPVVPKSTRIEVFKDDDNPSQSTHHKNTQVQVQTTTSILPLKPVVDGNLAHETPVKPSLTSNASRSPTVTAFSKDAINEVFSMFNQHYSTPGALLDGDDTTTSKFNVFENFTQEFTAKNIEDLTEVKDPKQETVSQQTTSTNETNDRYERLSNSSTRPEKADYMTPIKETTETDVVPIIQTPKEQIRTEDKKSGDNTETQTQLTSTTIQSSPFLTQPEPQAEKLLQTAEHSEKSKEHYPTIIPPFTKIKNQPPVIIENPLSNNLRAKFLSEISPPLFQYNTFYNYNQELKMSSLLKKIHRVSRNENKNPIVDFKKTGDLYCIRGELGEGGYATVYLAESSQGHLRALKVEKPASVWEYYIMSQVEFRLRKSTILKSIINASALHLFLDESYLVLNYASQGTVLDLINLQREKAIDGNGIMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPGEPLGAHYMRNGEDGWENKGIYLIDFGRSFDMTLLPPGTKFKSNWKADQQDCWEMRAGKPWSYEADYYGLAGVIHSMLFGKFIETIQLQNGRCKLKNPFKRYWKKEIWGVIFDLLLNSGQASNQALPMTEKIVEIRNLIESHLEQHAENHLRNVILSIEEELSHFQYKGKPSRRF
What is the function of this protein?
Involved in cell cycle checkpoint enforcement.  The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.  Catalyzes the phosphorylation of BUB3 and its autophosphorylation.  Associates with centromere (CEN) DNA via interaction with SKP1.  The association with SKP1 is required for the mitotic delay induced by kinetochore tension defects, but not for the arrest induced by spindle depolymerization or kinetochore assembly defects.
What are the official names of this protein?
Checkpoint serine/threonine-protein kinase BUB1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACLF_ASPOR
Sequence: MSSTAFTSSLSNWDLYPTNGSITPHLLLVGAQILFLSGPHFHGRRTLAATTILSLAAIAQYNRFTNNPGVANLFALAWPHWLSAVEKIVFASPEGPEADLWRVDRVPREAMSWPVFGWRKVKWAVTLLLNLRGIRWSFQVKNVPKMPERMTRGQFLRWRLGELVWVLLMTDLVSQMMLRFFFTDAAGALGNLDSKYITIRDARWGWSLLKALTFGLGPYFFINMQYLVVSILAVAMGISRPEVGSCPPRRSNRQPC
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells (PubMed:25302411).  The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues (PubMed:25302411).  One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine (PubMed:25302411).  After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT (PubMed:25302411).  In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine (PubMed:25302411).  Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway (PubMed:25302411).
What are the official names of this protein?
Aspirochlorine biosynthesis protein F.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.