PharMolix/UniProtQA huggingface dataset:
Protein: ACKA_CARHZ
Sequence: MKVLVLNCGSSSLKYQLLDMEKETVLAKGLVERIGLEGSRLIIDLPGREKIKKEQPFVNHEVAINAVLEELVREEYGILRNLEEITAIGHRIVHGGEKFSGSVIINEEILKAVEECVNLAPLHNPPNILGIRACQKLLPNTPQVGVFDTAFHQTMPRKAYLYGVPYYWYEKYGIRRYGFHGTSHKYVAYKASEILGKPLNELKIITCHLGNGSSVAAVKEGKSIDTSMGFTPLEGLLMGTRSGNIDPAIVTFIQEKEGLSAAQVNDILNKKSGVLGISGYSDFRDIEERASAGDDKAKLALEMFCYQVAKYIGAYAAAMNGVDAIVFTAGVGENSDVVRKEVCKYLEFLGATLDEEKNKIRGKEAIISTPDSKVKIMVIPTNEELMIAKETLELVVNK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2824_BORBU
Sequence: MTAIIVYSCLTMCVIYFHLQLKTFFTKLIRFCKKCFDIFLLLIEMLKLIFYLLIINNKFYIFIIISIALITINTMI
What are the official names of this protein?
Uncharacterized protein BBD24.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS20_SOLM1
Sequence: MANHKSAIKRHRQNLLARARNRAVKTRVRNVIKAVRAALIGGDAAAAETALLTATKVLDKAATKKIIHWKTAARNISRLSTAVNKAKSA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: CRYAA_ORYAF
Sequence: MDVTIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDQFLILLDVKHFSPEELTVKVLDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKVQSSMDDGHSERAIPVSREEKPSSVPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: SPOK2_PODAN
Sequence: MSDKDRIAQLLRELEEAKAREEEAKARAEEAKARAEEAKARAEEAKAREEEAKAREAQERCERERLQLEHRNTTFLEYLHNCHRHLYNALRLTNTSRYSTGYTKVVGKYYPKRLRPWTYFANVLHPHYFDLVQSICGQRQLFEPANTTKSLGTIISDHLAGNEKAIDRFEVDAVERPVQGILKVLATHKEAGKASICPEFRFSANLRELTQKDDGSSGADDNTSDGSLERRQQAGPNKRPTSKRKYICSNRQPDGVGIRMQPGGGQTHAFIYDYKAAHKVAIEYIRSATAKEHLFHEVVARINDDKLSRDEEVQRREQAEALIAMALTQVFDYMITYGVSYGYVAAGRCLLLLYVDRDDWQTLYCHPCLPADDVGEPTNDWTDRLSHTAVAQLISFCLSSFQSEALEGQSLETALSIAKATLKTWSESYADVAYLGLEPAELSSAPSSQNTDISEYTSKAEPTGRNVALRSQSSCKPAAVLPQSNEHDDEEDHSEPGASRLRLAANKRKRGPSSGGEDGDIAMADSGPTKQYCTQACLLGLKRGKDLDEKCPNVSLHRFDGSSRHPVNAHRFTDMVEQQLLLSPYKGCRMVDFWGKRGAMGWLFKLELLPYGYTFVGKGTLEDRLSRLEHEGRVYAQLDHLQGDVVPVYLGLVRLDRGYILPGLEFVVHMMLMSWAGQTPSASMDDAETLKRESLTAIWNEGVVHGDENRANYLWNAERGRIMIIDFDRAHLSPPPKPRAVSRLSKPKRKRGDSEADAQLFGPLEINRSKHRIRT
What is the function of this protein?
Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system, leading to poisoning of progeny that do not inherit the allele (PubMed:24830502, PubMed:31347500).  May possess DNA nuclease activity that leads to spore killing, and a kinase activity that confers resistance to the nuclease activity (By similarity).
What are the official names of this protein?
Meiotic driver SPOK2, Spore killer 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: IACX2_WHEAT
Sequence: MAFKHQLILSTAILLAVLAAASASFREQCVPGREITYESLNARREYAVRQTCGYYLSAERQKRRCCDELSKVPELCWCEVLRILMDRRVTKEGVVKDSLLQDMSRCKKLTREFIAGIVGRE
What are the official names of this protein?
Trypsin/alpha-amylase inhibitor CMX2, ITRL-2.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: YXIB_BACSU
Sequence: MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHLIHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYSIRRQITRIEHEIEKEKHKK
What are the official names of this protein?
Protein YxiB.
Protein: IF2P_HALLT
Sequence: MTDHTNADTLRTPIVAVLGHVDHGKTSLLDTIRGSAVSEGEAGAITQHIGATDIPLDTISEMAGELIDPTDFDLPGLLFIDTPGHHSFSTLRARGGALADIAVLVVDVNDGFQPQTEEAIDILRRTGTPFVVAANKVDTTPGWNPQDGQPIQRSLEAQSERAESMLNENLYEIIGQLSDAGFSADLYWRVQDFQKNIGVVPLSAITGEGVPDLLTVLMGLSQRFMKEEMAIDVQGPGEGTVLEVKDERGFGATIDTVVYDGVVRNGDQIVVGGQDEPIVTEIRALLQPRPLEEIRTEKKFEKVAEVGAAAGVKIAAPDLDRAMAGAPVRVVRDRPVEEVVEEVKAELAEIEVETAENGVVVKADTLGSLEAMANALREAEVPILRAEVGDIAPRDIAVAETANQDEHKAILGFNVDLLANAETELENADVKLFTDEVIYQLIEDYETYVEEKQRAQQETVLDKVVRPSRFRILPDHTFRQNDPAVVGVEVISGTVQNNRNVGYFEGNEFERVGQLSGIQKQGDDVDEARAGERVSIAIDGPTVGRDIEEGDTLWTEIPEKHAKILEQELKEEITADEREALAAYLETKRKRDPFWGK
What is the function of this protein?
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes.  Seems to function along with eIF-2.
What are the official names of this protein?
Probable translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Protein: CP046_RAT
Sequence: MDLCEESETFLENKENKKIEDAEETALTFHCPDERSERNHVCCLLGVSELTLEEDGRASEFTISTGWEEAVHGWGRTSPTACIWSKKKVRRGRVGEGTSGGSNCLFCMSLSQGSLEPRPLSAAGKLEEAAVAEVSSQKNWGSEKNWNSPSQGPASREPNKLCFPTYLHGEKKSLQMKEFIWCMEEWGIPEAVSSKACRNPSSSTDQGLSISDAVATKALVVLPPLKSSSHNLDSLSKKSRNIFWQPEEKVLGVEKDECMACPDELKGVDGKGEKAHFELASRLKVTNILPFPPTVTRTHLLSAESQRCCLHWSLLPQKSSVFPPNPTNIHYLATLQVLGQQGGQNCRTRLKAKEAKPPRTTPKHIVTEAKQESRPHVLESKVFPKPLLPSLTVSRVVIPVSTHRVL
What are the official names of this protein?
Uncharacterized protein C16orf46 homolog.
Protein: SSCA_BACSU
Sequence: MSGGYSNGFALLVVLFILLIIVGAAYIY
What is the function of this protein?
Spore protein involved in the assembly of several components of the spore coat, including CotB, CotG and CotH, and in spore germination.
What are the official names of this protein?
Small spore coat assembly protein A.
What is the protein family that this protein belongs to?
Belongs to the SscA family.
What are the subcellular locations of this protein?
Spore coat. Membrane; Single-pass membrane protein. Note=Accumulates in mature spores.
Protein: Y076_PSET1
Sequence: MQLSANQQRIIGCLLEKQSTTPEHYPLSLNALTNACNQKSNRAPVLNLTDSEVQIALDELINARLVTIDEGLSGRVNKYDHRFCNTEFSSLKFSAQQRAIICLLLLRGAQTPGELKTRCARLANFNSVDDVELALNKLIESDIVTKLAREPGKRDCRYMHLLGEQPISEITRPAEQATDELKSEELNELLAEVDELKTELQKIKAHLGL
What are the official names of this protein?
UPF0502 protein PSHAa0076.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: ISC2_BOMMO
Sequence: DKPTTKPICEQAFGNSGPCFAYIKLYSYNQKTKKCEEFIYGGCKGNDNRFDTLAECEQKCIK
What is the function of this protein?
Also inhibits trypsin weakly, this may be due to the presence of a pseudo-reactive bond in positions 44-45 (Lys-Gly).
What are the official names of this protein?
Chymotrypsin inhibitor SCI-II.
Protein: Y744_HAEIN
Sequence: MQEFISMATEFAQKHTLLAVSWFAIFVMVIYTFYKGATSKFKVITHNEVIRLINSDEAIVVDLRSLEEFQRGHIINSINVLPSEIKNQNIGKLESHKENALILVDTNGTSASASAVFLTKQGFNSVFVLKEGLSAWVAANLPLVKKHK
What are the official names of this protein?
Uncharacterized protein HI_0744.
Protein: LAMB_ENT38
Sequence: MITLRKVPLALAIAAGILSAQAGAVDFKGYARSGIGWTGSGGEQQCFQATGAQSKYRLGNECETYAEIKLGQEVWKEGDKSFYFDTNVAYSVAQQNDWEATDPAFREANVQGKNLIDWLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGLENIDVGFGKLSLAATRSSEAGGSSSFASNSIYDYTTRTANDVFDVRLAQMEINPGGTLELGADYGRANERDGYYLVDGASKDGWMFTAEHTQSMLKGFNKFVLQYATDSMTSQGKGLSQGSSIGTSDNINYAMNNNGHLWRVLDHGAISLGDSWDLMYVGMYQDINLDSNNGTKWWTVGVRPMFKWTPIMSTLLEVGYDNVKSQETGDTNNQYKITLAQQWQAGDSIWSRPAIRVFATYAKWDEKWGYAPSGNNTKAGYNPGVAYSDTSLNSFSRGDNDEWSFGAQMEIWW
What is the function of this protein?
Involved in the transport of maltose and maltodextrins.
What are the official names of this protein?
Maltoporin, Maltose-inducible porin.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: RUVB_SALAR
Sequence: MIEADRLISAGATIAEEVADRAIRPKLLAEYVGQPQVRSQMEIFIQAAKLRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVPDLQHIVGRSARHMGLEMSDDGALEVARRARGTPRIANRLLRRVRDFAEVKHDGAISAEIAAQALDMLNVDAEGFDYMDRKLLLAVIDKFFGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFLQRTPRGRMATVRAWNHFGITPPEMP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LDHA_SQUAC
Sequence: MATLKDKLIGHLATSQEPRSYNKITVVGVGAVGMACAISILMKDLADEVALVDVMEDKLKGEMMDLQHGSLFLHTAKIVSGKDYSVSAGSKLVVITAGARQQEGESRLNLVQRNVNIFKFIIPDIVKHSPDCIILVVSNPVDVLTYVAWKLSGLPMHRIIGSGCNLDSARFRYLMGERLGVHSSSCHGWVIGEHGDSSVPVWSGMNVAGVSLKELHPELGTDKDKENWKKLHKDVVDSAYEVIKLKGYTSWAIGLSVADLAETIMKNLCRVHPVSTMVKDFYGIKNDVFLSLPCVLDNHGISNIVKMKLKPDEEQQLQKSATTLWDIQKDLKF
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A, LDH-M.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAP1_RAT
Sequence: MAAHAWPTAALLLLLVDWLLLRPVLPGIFSLLVPEVPLLRVWAVGLSRWAILGLGVRGVLGVTAGARGWLAALQPLVAALGLALPGLASFRKLSAWGALREGDNAGLLHWNSRLDAFVLSYVAALPAAALWHKLGGFWAPSGHKGAGDMLCRMLGFLDSKKGRLHLVLVLLILSCLGEMAIPFFTGRITDWILQDKTAPSFARNMWLMCILTIASTVLEFAGDGIYNITMGHMHSRVHGEVFRAVLHQETGFFLKNPTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLCLLAFMIWGSFYLTVVTLLSLPLLFLLPRRLGKVYQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSVSGMLLKVGILYLGGQLVVRGAVSSGNLVSFVLYQLQFTRAVEVLLSIYPSMQKSVGASEKIFEYLDRTPCSPLSGSLAPLNMKGLVKFQDVSFAYPNHPNVQVLQGLTFTLYPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLDGEPLVQYDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLTRTPTMEEITAVAMESGAHDFISGFPQGYDTEVGETGNQLSGGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYESPEWASRTVLLITQQLSLAERAHHILFLKEGSVCEQGTHLQLMERGGCYRSMVEALAAPSD
What is the function of this protein?
ABC transporter associated with antigen processing (PubMed:17018292).  In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (By similarity).  Uses the chemical energy of ATP to export peptides against the concentration gradient (By similarity).  During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen.  Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules.  Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (By similarity).  As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (By similarity).
What are the official names of this protein?
Antigen peptide transporter 1, APT1, ATP-binding cassette sub-family B member 2, Peptide transporter TAP1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
Protein: COPZ3_ORYSJ
Sequence: MESCPSVKNILVLDSEGKRVAVKYYSDDWPSLSSKQAFEKSVFAKTQKTSARTEAEIVMFDSYFVVYKFIQDLHFFVTGGDEENELILASVLQGFSEAIDYLLRNKVHRRAALENLDLIFLCLDEVVDGGIVLETDAKAILEKVSGHGLEGSGSLTEQKLSSALATAREHFARSIFS
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).  The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
What are the official names of this protein?
Coatomer subunit zeta-3, Zeta-3-coat protein, Zeta-COP 3.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: PUS10_PYRAR
Sequence: MELISKALEAVRRYPLCDSCLGRLFALMGYGIENRERGQAIKTILHMAAVSDYRKGKDVTADLIALAKCHLPTRRFLAGVGIRVDEERCYICGDLMEGVEKYAEMAVEQLRGLDFVSFAVGSTLPEELLEKEAEVVKSLLVTTGESVKHEVNRRIGKELLRRLSDKRVDKLRPNVVVNVDLVSGQVKVVRNPILIGGRYLKLGRKIAQAKRFGNVRTTLLEKLAYLRDTFGGEDHVIHVSGREDSDARMLGSGRPLVVEVKQPLRYTAQVAPFRDKDVIFLPVGFTDRNEVRRLKEKAKTDIKLYRVLVLSESPLKQDDLSKLSALSGATVTQYTPRRIKRLHPRKKRVRMVYDVAWRLVSPHVFELYIRCQGGLYVKEFVHGDGGRTAPNVAELLNTRLEVLELDVLYIE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase Pus10, tRNA pseudouridine 54/55 synthase, Psi54/55 synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase Pus10 family.
Protein: CWP07_SOLLC
Sequence: EVPLDDTGL
What are the official names of this protein?
62 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: PYRH_CROS8
Sequence: MATNAKPVYKRILLKLSGEALQGAEGFGIDASILDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAFPLNGVCDNYSWAEAISLLRNNRVVIFSAGTGNPFFTTDSAACLRGIEIEAEVVLKATKVDGVYSADPMKDPTATLYDQLSYQEVLEKELKVMDLAAFTLARDHKLPIRVFNMNKPGALRRVVMGEKEGTLITE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_RUEPO
Sequence: MPSLNDIRSTFLNYFAKQGHTIVPSSPLVPRNDPTLMFTNSGMVQFKNCFTGVDKRDYVRATTAQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKSEAIPFAWELITRDFDIPKDRLYTTVYHTDDEAFEIWKKVGVPESRIIRIATSDNFWQMGPTGPCGPCTEIFYDHGDHIWGGPPGSPEEDGDRFIEIWNIVFMQNEKFEDGSMVDLDMQSIDTGMGLERIGALLQGSHDNYDTDLFKALIEASADATSVDPYGDQNVHHRVIADHLRSTSFLIADGVMPSNDGRGYVLRRIMRRAMRHAHLLGAKDPVMHRLVRTLVGQMGAAYPELGRAQALIEETLLLEETRFKQTLDRGLKLLDDELTALPEEAPLPGEAAFKLYDTYGFPLDLTQDALREKGRKVDTDGFDAAMAEQKAKARAAWAGSGESTDNAIWFDVLDVAGATDFLGYDTEKAEGQALALVVDGALSDRIAEGGSGWVVTNQTPFYGESGGQVGDTGVIRRLENRDHVALVEDSRKFADGKVYAHKVTMERGALAKGDAVELEVDHARRSAIRANHSATHLLHEALREALGDHVAQRGSLNAADRLRFDFSHAKALTEAELAQVGAEVNRFIRQNSRVETRIMTPDDARAIGAQALFGEKYGDEVRVVSMGRAETGKGADGKTWSIELCGGTHVAQTGDIGMFVLLGDSASSAGVRRIEALTGQAAFDHLSQEGARLSQVTAMLKAQPAEVAERVRALMDERKALQNEVAQLRRDLAMAGGAGQGGGAETHEVGGVPFLAQVLSGVSGKDLPALIDEHKSRMGSGAVLLIADAGGKAAVAAGVTEDLTARVSAVDLVKAAVAALGGKGGGGRPDMAQGGGQDAGKADAAIKAAEQVLGG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_LACH4
Sequence: MVMTDPIADYLTRIRNANMAKHDSVEIPASNIKKSISEILKREGFIRDYEVADDNKQGVIKVFLKYGPNGERVISGLKRISKPGLRNYVSAEDLPKVLNGLGIAIVSTSAGVITDKEARQKNVGGEVIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RL27_STRM5
Sequence: MAHKKGVGSSRNGRDSNPKYLGVKIFGGQAIEAGNIIVRQRGTQFHPGSGVGLGRDHTLFALVDGKVEFSVKGAKKRRTVSVVSVEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SO2B1_RAT
Sequence: MPDRSTKATMGAEDIHERKVSMEPRDSHQDAQPRGMFQNIKFFVLCHSILQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLAAFNEVGNISLILFVSYFGSRVHRPRMIGCGAILVAVAGLLMALPHFISEPYRYDHSSPDRSQDFEASLCLPTTMAPASALSNDSCSSRTETKHLTMVGIMFTAQTLLGIGGVPIQPFGISYIDDFAHHSNSPLYLGILFAITMMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTTKDPRWVGAWWLGFLISAGLVVLAASPYFFFPREMPKEKYELHFRQKVLAGGASIGSKGEELSSQHEPLKKQAGLPQIAPDLTVVQFIKVFPRVLLRTLRHPIFLLVVLSQVCTSSMVAGTATFLPKFLERQFSITASFANLLLGCLTIPLAIVGIVVGGVLVKRLHLSPMQCSALCLLGSLLCLLLSLPLFFIGCSTHHIAGITQDLGAQPGPSLFPGCSEPCSCQSDDFNPVCDTSAYVEYTTPCHAGCTGRVVQEALDKSQVFYTNCSCVAGNGTISAGSCESACSRLVLPFILLISLGAAVASITHTPSFMLILRGVKKEDKTLAVGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRNRFIGLQFFFKSGSLVCFALVLAILRQQSREASTKATVKSSDLQEL
What is the function of this protein?
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), leukotriene C4, thromboxane B2 and L-thyroxine (PubMed:10973807).  Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons.  May act as a heme transporter that promotes cellular iron availability.  Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (By similarity).  May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity).  Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment.  The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound.  Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions.  Cytoplasmic glutamate may also act as counteranion in the placenta (By similarity).
What are the official names of this protein?
Solute carrier organic anion transporter family member 2B1, Organic anion transporter moatp1, Organic anion transporting polypeptide 2B1, OATP2B1, Solute carrier family 21 member 9.
What is the protein family that this protein belongs to?
Belongs to the organo anion transporter (TC 2.A.60) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IFT43_TAEGU
Sequence: MEAEPERAEAPRRGGVAAVLKMGRRARQDIFAGENLSRKNSPSASLGEVPPPKPPRRQGGWADDPVLAPTKSGRKHAEEVEDHRLRQQSLEASDDGGDIPVIPDLEDVQDEDLAMQVAAPPSVQVNRVLTYHDLDKDLMKYAAFQTLDGEVDLKLLTKVLAPEHELREDDVSWDWDHLFTEVSSELVTEWDLGQSEREDHISLP
What is the function of this protein?
As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis.  Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.
What are the official names of this protein?
Intraflagellar transport protein 43 homolog.
What is the protein family that this protein belongs to?
Belongs to the IFT43 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Associated with microtubules. Localized at the distal tip of the cilium.
Protein: CAV1_MICMU
Sequence: MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADEVSEKQQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLFEAIGKVFSNIRINMQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: RL4_CORK4
Sequence: MSNLTLDVHTADGSTNGTVDLPSSVFDVEVSTPLLHQVVTAQLAARRQGTHATKTRGQVRGGGRKPYRQKGTGRARQGSIRAPQFTGGGTVHGPQPRDYDQRTPKKMKAAALRGALSDRARHDRIHVVEDLVPGQTPSTKAARTFIGRLTDRKSVLVVLGREDVNSIKSARNLPNVHILPSDQLNTYDVLNSDDLVFSVEALNAFIERATGAETKEESK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.