PharMolix/UniProtQA huggingface dataset:
Protein: IRAK2_MOUSE
Sequence: MACYIYQLPSWVLDDLCRNIDTLSEWDWMQFASYVITDLTQLRKIKSMERVQGVSITRELLWWWSMRQATVQQLVDLLCHLELYRAAQIVLSWKPVPESTSPLPAFPEAVKPGAVATSRRNLKDEQEKVRPVKPRSLLDTGPIMAGAQRQRPCEMDAPCSLKTDAPDSPQSKYCSTSTSAPKQERLLGLPGDRLFWSEADVVQATEDFDQSHRISEGTFADIYQGQRNGVAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMANGSLHDRLWAQGNSDMLPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKLAHPVAHPHPDNKKTKYTVMRTHLFQASAAYLPEHFIRVGQLTKQVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPNSTSSVCSRKTSMGKAVVKEICQRHVEKRAGLLPEACEEAWATAVSVCLRRRNASVEEARVSLAGVEEQLRGQLSLPWSRVSEATGSSSNTPEETDDVDNSSLSVPSLVMMASCPGAASSPLFTGHGAAQPSTSGRQEADSSSEACTGPQTPQNATETSWKIEINEAKRRLMENIVLYKEERLDSSELFGP
What is the function of this protein?
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
What are the official names of this protein?
Interleukin-1 receptor-associated kinase-like 2, IRAK-2, mu-IRAK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Protein: COX2_RHYIS
Sequence: MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGDLRLLEVDNRIVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVSSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKTFENWSTSMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YPZH_BACSU
Sequence: MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEAILDGIAHRIGDDVYLIVKHF
What are the official names of this protein?
Uncharacterized protein YpzH.
Protein: HEM3_SALDC
Sequence: MLDNVLRIATRQSPLALWQAHYVKDALMATHPGLTVELVPMVTRGDVILDTPLAKVGGKGLFVKELEIALLEKRADIAVHSMKDVPVAFPDGLGLVTICEREDPRDAFVSNKYHSLDDLPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLGKLDNGDYDAIILAVAGLKRLGLESRIRTALPPDVSLPAVGQGAVGIECRLDDARTQALLAPLNHSQTALRVTAERAMNTRLEGGCQVPIGSYAEIINGEIWLRALVGAPDGSVMVRGERRGSPEQAEQMGISLAEELLENGARAILTEVYNGETPA
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RUVA_PARL1
Sequence: MIGKLRGIVDSTGEDWAVIDVGGVGYHVTCSSRTLRNLPPAGGAVTLSIETKVSDEAIRLIGFTTDSEREWFRLLLAVQGVGTRVALGVLGTLAPADLARAIALDDKKAVSAAPGVGPKVAARIVTELKDKVPDSMGLSAALEVGVNGEAVSSVSAPARDAVSALVNLGYPQAQAMGAVAAAAKRLDDAASTEQLIRHGLKELAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: SMIM8_DANRE
Sequence: MSSGQSSSSSGKAGPQEPPSSAAEPAYRSPGLRGVRTTSLFRAVNPELFIRPNKPVMALGLLALSVCVGYLGYLHAIRDSDQQLYEAVDSDGETYMRRRTSRWD
What are the official names of this protein?
Small integral membrane protein 8.
What is the protein family that this protein belongs to?
Belongs to the SMIM8 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RM02_RECAM
Sequence: MILKKYKPTTPSLRGLVQIDRSLLWKGDPVKKLTVGMIESAGRNNTGRITVYHRGGGHKTKYRYIDFKRSNYNIPGIVERLEYDPNRTCFIALIKDNENNFSYILAPHDLKVGDTVITGNDIDIRIGNTLPLRNIPIGTMIHNIELNPGKGGKIVRSAGSSAQLISKDENGFCMLKLPSGEYRLFPNNSLATIGILSNIDNKNIKIGKAGRSRWMGRRPIVRGVAMNPVDHPHGGGEGKTSGGRPSVTPWSWPTKGQPTRSKRKYNKLIVQRAKKKI
What are the official names of this protein?
60S ribosomal protein L2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RNT_AZOVI
Sequence: LQEIFRGVRKAVKSHGCKRAILVGHNSSFDLAFLNAAVARCDIKRNPFHPFSSFDTATLAGLAYGQTVLAKACQSAGIEFDGREAHSARYDTEKTAELFCGIVNRWKEMGGWVDFA
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: RFCL_THEKO
Sequence: MTEVPWVEKYRPRKLSEIVNQEKALEQVRAWVEAWLHGNPPKKKALLLAGPPGVGKTTTVYALANEYGFEVIELNASDERTYEKIERYVQAAYTMDILGKRRKLIFLDEADNIEPSGAREIAKLIDKARNPIIMSANHYWEVPREIRNKAQIVEYKRLTQRDIIKALVRILKREGLEVPKEVLYEIAKRANGDLRAAVNDLQTVVTGGVEDAVEVLAYRDTEKSVFQALAQLFATDNAKRAKLAVLGVDMMPNELLQWIDENVPYVYYRPEDIARAYEALSRADIYLGRAQRTGNYGLWKYATDMMTAGVAVAGIKKKGFVKIYPPKTIKLLTESKEERSLRDSVIKKIMSEMHMAKLEAIETLRYLRVIFENNPDLAAHFVVFLDLSEKEVEFITGDKEKAKTIWAKSMNIEKKLKKEGELEARAKEAERRVEAAEEEETMEAGEPEEELEEVEEEELTEEELEEAEEEIETVGKKEKPEKEKTKKGKQATLFDFLKK
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C large subunit, RFC large subunit, Clamp loader large subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcL subfamily.
Protein: Y3027_XANCP
Sequence: MGRGPSIEGRKNASDAKRGKIFTKIIREISVAARAGGGDPSNNPRLRTAMDKGLSSNMSKDVIERAIKKATGELEGVEYEEVRYEGYAPGGVAVIVDCLTDNRVRAVADVRHAFSKCGGNMGTDGSVAFMFKRLGVLSFAAGADEDAVTEAAIEAGADDVVVYPEDGAIDVLTAPDTFAQVKQALATAGFEPAHAEITFRAENDIAVDGDTAVQVRKLLDMLEDLDDVQDVYSNVDQASLGA
What are the official names of this protein?
Probable transcriptional regulatory protein XCC3027.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_BURMS
Sequence: MKQDSRFPNLFILDHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPITTKRVETPLVEIDAPVIAGKKLAIVPVLRAGVGMSDGLLELIPSARVGHIGVYRADDHRPVEYLVRLPDLEDRIFILCDPMVATGYSAAHAIDVLKRRGVPGERLMFLALVAAPEGVQVFQDAHPDVKLYVASLDSHLDDHAYIVPGLGDAGDRLFGTKN
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: PROA_PROMM
Sequence: MTTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALMAMANALLSSSEQIVRANQLDLEKARTEGLASALMARLRLDESKLNSAIEGLRQLAQLTDPLGLRQLHRELDQDLVLERITVPLGVLGVIFEARPDAVIQITSLAIRSGNGALLKGGSEASHTNQAIIEALKNGLAETEIDPEAIALLKTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLDAAADLKQALQIAIDSKTQYPAACNSIETLLIHQSIAPSFLELAIPAFLQAGVRLLGDSASRALGVEESASEEDWATEYLDLILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERFLQAVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRYRLRGQGHIVADYANGECMFTHRDLPL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDH2_CANTR
Sequence: MGEIQKITVKNPIVEMDGDEMTRIIWQFIKDKLILPYLNVDLKYYDLGIEYRDKTDDKVTTDAAEAILQYGVGVKCATITPDEARVKEFNLKKMWLSPNGTLRNVIGGTVFREPIVIDNIPRIVPSWEKPIIIGRHAFGDQYKATDVVIPAAGDLKLVFKPKDGGEVQEFPVYQFDGPGVALSMYNTDASITDFAESSFQLAIERKLNLFSSTKNTILKKYDGKFKDIFEGLYASKYKTKMDELGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVQSDIVAQGFGSLGLMTSVLVTPDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIYAWTRGLIQRGKLDDTPEVVKFAEELEKAVIETVSKDNIMTKDLALTQGKTDRSSYVTTEEFIDGVANRLNKNLGY
What is the function of this protein?
May play a role in N-alkane metabolism, glutamate synthesis, and/or NADPH generation in the peroxisomes.
What are the official names of this protein?
Isocitrate dehydrogenase [NADP] peroxisomal, IDH, CtIDP2, Oxalosuccinate decarboxylase, PS-NADP-IDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: RNY_STRSY
Sequence: MNIITVVVTLVSALIGLVLGYFAISLKMKSAKETAELTLLNAEQEASNVRGRAEEQAEVILKTAERDRQTLKKELLLEAKEEARKYREEIAEEFKSERQELKQIESRLTERATSLDRKDDNLTNKEKTLEQKEQSLTDKAKHIDEREQEVVKLEEQKALELERVAALSQEEAKEIILTDTRDKLTHEIATRIKEAEREVKERSDKMAKDLLAQAMQRISGEYVAEQTITSVHLPDDAMKGRIIGREGRNIRTFESLTGIDVIIDDTPEVVVLSGFDPIRREIARMTMETLLQDGRIHPARIEELVEKHRVEMDNRIREYGEAAAYEVGAPNLHPDLIKIMGRLHFRTSYGQNVLRHSIEVAKLAGVLAAELGENVNLARRAGFLHDVGKAIDREVDGSHVEIGTELAKKYKENPIVINAIASHHGDVEATSTIAVIVAAADALSAARPGSRRESMEAYIKRLQDLEEIANSFEGIKQSYAIQAGREIRIIVHPNKVTDDQITILAHDVREKIENNLDYPGNIKITVIRETRATDVAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RL3_UREP2
Sequence: MKSLLGTKVGMTQVFTETGKAVAATVIYVEPNKVLAVKTNEKDGYSAIQIGYETVKEKALNKPLLGQFKKANSDPKRHIKEFRDVVAEVGAELTVSEFEPGQLVNAQAYTKGHGFTGSIKRHNFSMGPMGHGAGYPHRYVGSIAKGRGGSQAQRVFKGTKLPGHYGHELVTTKNLLVLDVKANENLILIKGAIPGPKGSIVLLKSAKKVGHIVSDPQVVNYLANKASSSEANE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RSMH_RHORT
Sequence: MNALTPHFPVMLDEVLSALEPHADGLYVDGTFGNGGYSRGLLERADCRVIAIDRDPAARVRGAALEAEFPGRFTLLSGCFGDMEQLLAAEGISRIDGVALDLGVSSMQLDQAERGFSFQKDGPLDMRMGQQGQTAADLVNTLDEDRLADILYHYGEERKSRWVAHAIVERRAETPFSRTADLATVIRGVVRKSRDGIDPATRSFQALRIVVNDELGELERALGASERLLRAGGRLVVVAFHSLEDRIVKAFVRQRCGESEGVSRHLPQASNAGAGNPPPSFQAVSRRAVKPLDAETRVNPRSRSARLRAVERTEFPAWTVSPGGQR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIK1_ARATH
Sequence: MDHNSPKSRRSRKPEPKPDIYSTFVVHSDSDSDQGRDRDKRKAKPEEDENVDLYATMVYKGDSDGEGEEDDDDDSMLPPLLKRLPKDFGGGASLDYDDDDGDESGDFGTMIVKTDRSSHSKKNSPYSSKPRMGVSPRRRARGGDEESSDEEDEEEDDDDDDGDYGTFVVKSKDKKGKKKDKEIDMTTMGRAVASMQKSNFGGKTRKLDPSSSSSKLHGEDNRKMQQQNSKMSTTSLPDSITREDPTTKYEFLNELGKGSYGSVYKARDLKTSEIVAVKVISLTEGEEGYEEIRGEIEMLQQCNHPNVVRYLGSYQGEDYLWIVMEYCGGGSVADLMNVTEEALEEYQIAYICREALKGLAYLHSIYKVHRDIKGGNILLTEQGEVKLGDFGVAAQLTRTMSKRNTFIGTPHWMAPEVIQENRYDGKVDVWALGVSAIEMAEGLPPRSSVHPMRVLFMISIEPAPMLEDKEKWSLVFHDFVAKCLTKEPRLRPTAAEMLKHKFVERCKTGASAMSPKIEKSRQIRATMALQAQSVVAPSLEDTSTLGPKSSEELGITVPSKPPQNSTEAPLTSTLNRQHITGNTVLAGEGGDFGTMIVHGEDETEESDSRSQLVREKESSSSQFEGVPREFPGEELPDSWIHDKKKPPAIDLPVEASISQSMQASSSHEHRTKLHNIAGTQMEGGSDASGSTLKNETVGRKAFALQDKLWSIYAAGNTVPIPFLRATDISPIALLSENMIGGMQQDGNGTVAVEALQELFTSSDPQSKKGRRGQNEMPLPPSVYQRLTTSSSLMNLAQVLAYHRACYEEMPLQELQATQEQQTIQNLCDTLRTILRL
What is the function of this protein?
Serine/threonine-protein kinase (PubMed:30212650).  Regulates organ size in coordination with MOB1A by modulating cell proliferation and cell expansion, possibly by facilitating cell cycle exit (PubMed:26685188).  Positive regulator of the pathogen-associated molecular pattern (PAMP, e. g.  flg22)-triggered immunity (PTI) signaling by stabilizing BIK1 and activating RBOHD by phosphorylation to promote the extracellular reactive oxygen species (ROS) burst involved in defense responses to bacterial infection (PubMed:30212650).
What are the official names of this protein?
Serine/threonine-protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Early endosome. Note=Observed at the plasma membrane and in the nucleus when associated with MOB1A.
Protein: DDHC_RHOSU
Sequence: MPGFRFLLAATAAFLATSPALPLSADSLNAGNIRLVDPEETVPVIKIPDGIYLRTPNDPDDIIWARVPEFRVEMVMAPPVHPSVGLRYRDEYPEQDLVVQLARTSERFYVRLRWVDPTRDMSTLRDRFRDGAAIEFSESDDSVSYMMGTDAESPVNIWYWHPDGDRVESLAAGSPGSLTRLDRQPVTGASEYRTGHGPDDSQWIVVMSRPLASEGDHQVSFERDTIPVAFALWQGADAQRDGLKLVSLNWIFARMTPDAAPAPGN
What is the function of this protein?
May transfer electrons to the iron-sulfur centers of DdhB.
What are the official names of this protein?
Dimethylsulfide dehydrogenase subunit gamma, DMS DH subunit gamma, DMS DH heme subunit, Dimethyl sulfide:cytochrome c2 reductase subunit beta, Dimethylsulfide heme subunit.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL25_WOLTR
Sequence: MTQQEMITINAELRDVTKTKAIRSLRKKGNIPAVVYGKGHNNVNLTLSAKEFTKQYKLGFLSAHVIELDISGKKEYALVRDIQWHVVKDTIQHVDFQFVDKGSEIKIDIPLSFVNESKSPGIKLGGVLNVLCRSITVKCSPDKIPQAIEVDLSGKMIGQSVHISDVKLPGGVKLAAHEEENFTVVTISAADSGVEESQVETTEE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: Y2002_DICD3
Sequence: MPFVNIRITKDGVTAEQKKQLIAGVTQLLVDTLGKNPATTVVIIDEVETDNWGIGGESVTERRQQAS
What are the official names of this protein?
Probable tautomerase K2.
What is the protein family that this protein belongs to?
Belongs to the 4-oxalocrotonate tautomerase family.
Protein: UBIE_CUPNH
Sequence: MSETHFGFEKVDEAEKADKVAGVFHSVASKYDVMNDLMSGGMHRLWKMFTIAQAGVRPGHKVLDIAGGTGDLAKAFAKQAGPTGEVWLTDINESMLRVGRDRLLNKGIVTPVCLCDAERIPFPDNHFDLVTVAFGLRNMTHKDAALAEMRRVVKPGGKVMVLEFSKVWKPLEKAYDVYSFKVLPWLGERVAGDAPSYRYLAESIRMHPDQASLVRLMEHAGLENVEYFNLTAGVVALHVGRKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: UVRB_METCA
Sequence: MLRSGYAPSGDQPEAIRRLVEGLNDGELHQTLLGVTGSGKTFTIANVIAQVQRPTLILAHNKTLAAQLYGEMKEFFPENSVEYFVSYYDYYQPEAYVPASDTYIEKDSSLNEHIEQMRLSATKALIERHDTVIVATVSSIYGLGEPASYFEMVLHLVRGDMIDQRTLVRRLAELQYTRNEAELRRGSYRVRGDVIDIYPAESEKEALRVELFDDEIERLSLFDPLTGEVISRIARYTVYPKTHYVTPREKLLEAVEEIKVELKDRLEHLRSQHKLVEAQRLEQRTLFDVEIILEVGYCSGIENYSRFLSGRAPGEPPPTLFDYLPDDALIVIDESHVTVPQIGAMYRGDRSRKETLVEYGFRLPSALDNRPLKFEEFEARAPQRIYVSATPGPYERAHSGAVVEQVVRPTGLVDPEVEVRPASTQVDDLLSEIRFRVQGGERVLVTTLTKRMAEDLTEYLMEHDVAVRYLHSDVDTVERVEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSAVSLIQTIGRAARNLHGKAILYADKVTQSMQQAIDETERRRAKQIAYNERHGLTPRGITKSVTDILEVSIPGGSAGSRKQAARVAEPGAGYKVAKPSEAARLIKQLEEKMYAHARDLEFEEAARLRDEIQRIRESALMA
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK1_NOSS1
Sequence: MGKVVGIDLGTTNSVVAVMEGGKPVVIANAEGMRTTPSVVGFSKDGERVVGQMARRQTVLNPQNTFFAVKRYIGRRYNELSPESKRVPYTIRKDEVGNIKVACPRLNKEFSAEEISAMVLKKLADDASAYLGSAVTGAVITVPAYFNDSQRQATRDAGRIAGLEVLRILNEPTAASLAYGLDRGDTETILVFDLGGGTFDVSILEVGDGVFEVKATSGDTQLGGNDFDKKIVDWLAEQFLETEGVDLRRDRQALQRLMEAAEKAKIELSAVSITDINLPFITATEDGPKHLETRLTRSQFEGLCVDLLGRVRNPVKRALKDAGLRPDDIEEVVLVGGSTRMPMVKQLVRDLIGIEPSENVNPDEVVAMGAAIQAGILAGEFKDVLLLDVTPLSLGLEAIGGVMKKLIPRNTTIPVRRSDIFSTSENNQNSVEIHVVQGEREMAGDNKSLGRFKLYGIPPAPRGIPQIQVAFDIDANGILQVTALDRTTGREQSITIQGASTLSESEVNRMIQEAQKYADVDRERKERVEKRTRSEALILQGERQLREVALEFGMQFARNRRQRIDNISRELKESLKENDDRGIDQAYADLQDALYELNREVRQYYAEDEDDDLFATIKDIFVGDKDKERDLPRDSYRERDAYNNRDYGRDYGRDYGRDSRPSYDNSRPPRKSPRPSYQDNWDDDDDWL
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein dnaK1, HSP70-1, Heat shock 70 kDa protein 1, Heat shock protein 70-1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MBL2_HUMAN
Sequence: MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI
What is the function of this protein?
Calcium-dependent lectin involved in innate immune defense (PubMed:35102342).  Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.  Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.  May bind DNA.  Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342).
What are the official names of this protein?
Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin.
What are the subcellular locations of this protein?
Secreted.
Protein: Y2553_TERTT
Sequence: MLIVIDALLAEAEVLKWRARLEDAEWLDGRGTGGTLSAAVKSNLQLPDTSELAINLGNTIVQKLGVHPLFLSAALPEKIYPPKFNCYRNGGAYGTHVDSAIMVMPNKQSLRTDISATLFLSDPDSYDGGELEIETAFGAQAVKLNAGDLVLYPSSSLHRVTPVTRGQRVASFIWIQSMVPDEAERALLFDLDQSIQSLISEKPADDPTLLRLTSVYHNLLRRYAKF
What are the official names of this protein?
PKHD-type hydroxylase TERTU_2553.
Protein: GLAH_SALNS
Sequence: MNALTAVKANTDDLAQRHTGFTLAPSAQSPRLLALTFTADTTRQFLHQVAQWPVQALEYKSFLRFKIGKILDDLCGNQLQPLLIKTLLNRAQGALLISAEGIDDVAQAEEMVKLATAVAHLIGRSNYDAMSGQYYARFVVKNVDNSDSYLRQPHRVMELHNDGTYVEEVTDYVLMMKIDEQNMEGGNSLLLHLDDWEHLESFFTHPLARRVMRWAAPPSKNVSHDVWHPVFDVDQQGRPVMRYIDQFVQPKDFEEGVWLSELSDALETSQNILSVPVPVGKFLLINNLFWLHGRDRFTPHPDLRRELMRQRGYFAYAASHYQTHQ
What is the function of this protein?
Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG).  Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Glutarate 2-hydroxylase, G-2-H.
What is the protein family that this protein belongs to?
Belongs to the glutarate hydroxylase family.
Protein: RS7_RHILW
Sequence: MSRRHKAEKREINPDPKFGDLVVTKFMNAIMLDGKKSVAENIVYGAFDVVQGKSKQEPLTVFHSALDNIAPHVEVRSRRVGGATYQVPVDVRPERRQALAIRWLIAAARKRNETTMVDRLSGELLDASNNRGSAVKKREDTHKMADANRAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: TM100_BOVIN
Sequence: MTDEPIKEILGTPKSPKPVAMEKNANGEVVVTLVPLVSEIQLAAATGGAELSCYRCVIPFAVVVLITGTVVTAVAYSFNSHGSIISILGLVLLSLGLFLLASSALCWKVRQRSKKAKRRESQTTLVVNQRGWFA
What is the function of this protein?
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10.  Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons.  Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.
What are the official names of this protein?
Transmembrane protein 100.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system (By similarity).