PharMolix/UniProtQA huggingface dataset:
Protein: PYRC_ELUMP
Sequence: MKYLIKNAHVIDPANKIDGLKDILIENGKIAAVENKIEDNAAKIIDAKGLTAMPGFVDMHTHLREPGQEGKETIFTGTKAALKGGFTTVCMMPNTNPAMDSKNNLAIAQDIIRKTANVNVEIMGAITKNRAGKELSNFAELKQAGAIALSDDGSGVEDDAVMQAAFKESVKQDILLISHSEDSKLSAGGVMNEGLISTKLGLKPISNASEYEMVKREIQLAKGLDAKIHIAHVSTKESCEIIAKAKKQGVMVTAEATPHHFTLTDKACESFSGNTKMNPPLRSEADVEALKQALKDGTIDAIATDHAPHAVHEKEVEFDLAYFGIIGLETAFPLAYDVLVKSGLIDMAKLVGLMSLNPSKILGLKKGTLTPGADADITIVDLNKQWVYSKEEVQSLSCNSPFIGKNLQGYIEYTFVGGELKLENGTLKVKDA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: SEC24_LODEL
Sequence: MSGRRRAYPQPQYSAAAPSGISSPPVSQFQQQQQQPGQPGQPQAGFQGAYGAAAGVPAYGADQLLGQFQQMSVGNGAAVGTPQQQFQQPQYPQAQYQQTQQQQQQAPQVNPQLSYDPYQPQPQAGIYGQGMGGIPPAAGVGAGAQPVASYGAYGQASNLAGGVQLNALYTTDLSRDLPPPIAELSYQPPPITLADTATIIPGSKTANASSDYFRSTLNVVPNNSSLLKKSKLPLALVVKPYNALKIPDENVPVTCDTVISRCRRCRGYINPFITLAENGRRWRCNFCNLLNDIPSAFEYDEISGQVKNKFDRVELNHSVVEFIAPKEYMARAPQPIVYVFIIDVSVHAVSSGLTGTITRTILESLDRIPNENKTARVAFIGVDTNLHYFRFNEGLDGTEIMVVADIDEPFLPSPGGLLVNLDENREAIEKLLYDFPSFFESTANQGFALGPALKAGHKLISNVGGKLVCFAATLPNIGEGKLSVRDEASVAGKPKEAKALLTPADSFYKSFAVNCNSSQVTVDLFLTSAAYQDVATLANLPRFTAGQTHFYPAWTSNKYEDVAKLSKEVSDHLSQDIALEAVLRVRGSTGFRMSSFYGNFFNRSSDLCSFPTFPRDQSYLIEMSIEETINKPVVYFQAAVLHSTSFGERRIRVMNLALPTSSKLVDVYASADQLAITNYFTHKAIEKALSSSLPEAREYLISRVVDILNIYRKELVAGNVSGASPLQISTNLRMLPLLLFCLTKNLAFRSDRVPSDHRAAALNNLGSLPIPQLIKSIYPTVYSLHNMPDSCGLPGVKEESEEDGNDDNDEQGVEVDVVLPEPINDSKSSWENYGLYLIDNGSELFLWVSGNVVPGLIQDVFGTENLYEIPTGKTELPEYSIEESEFNYRVRQIIGKVREQPDSIIWKNLYVVVGASSNEPIEISQQRDLMALRMWASSCLVEDKTGSEPSYRDFLTSLKSKVSQ
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC24.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC24 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ILVD3_BORBR
Sequence: MSDNNRSRHITEGVARAPNRAMYYALGYTEADFQNPMIGVANGHSTITPCNSGLQRLADAAIEAIRVSRANPQVFGTPTISDGMSMGTEGMKYSLVSREVIADCIETAAQGQWMDGVVVIGGCDKNMPGGMMALARMNVPGIYVYGGTIKPGHYKGKDLTIVSVFEAVGEYTMGRMDETDFKAIEQCAIPGSGSCGGMYTANTMSSAFEAMGMSLPHSSTMANEDQEKVASAAESARVLVEAVRRQLRPRDIITRASIENAVAVIMATGGSTNAVLHFLAIAHAAEVPWNIDDFERIRKRVPVICDLKPSGKYVATDLHRAGGIPQVMKILLNAGLLHGDCITITGKTVAETLANVPDAPPPGQDVIMPIERALYPQGHLAILKGNLSPEGCVAKITGLKNPVITGPARVFDSEDDAMSAIMDRRIRDGDVVVIRYEGPKGGPGMREMLAPTSALVGQGLGETVGLITDGRFSGGTWGMVVGHVAPEAFVGGPIALIREGDSVTIDAHQLLLQLNISDEEMAARRKAWAQPKPRYVRGVLAKFGKLACTASRGAVTDAFEE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase 3, DAD 3.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RL5_ACHLI
Sequence: MSAAFKELYNTKIVPKLVSDFNYDSVMQVPKLEKIVVNMGVGEAVSNSKLLDQAVEELTLLTGQKPVITKAKKSISNFKLREGQSIGAKVTLRGDRMYYFLEKLVSVALPRVRDFRGVSANAFDGRGNYTLGVKEQIIFPEINIDKVNKVRGMDIIIVTTAQTDAEAKSLLTEFGFPFKK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: CH10_COPPD
Sequence: MEIKPLGDRVLLKPMEEEEKTKSGIVIPDTAKEKPQKGKVLAVGTGRTLDNGTRVPLEVQVGDIVVFSKYAGTEVKVDGEEYLIVSERDILAVVGHEN
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPOT_MYCGE
Sequence: MATIQEIECDFLAKIAQKFTNAEIELINKAFYHAKTWHENQKRLSGEPFFIHPLRTALSLVEWNMDPITICAGLLHDIIEDTDQTEANIAMIFSKEIAELVTKVTKITNESKKQRHLKNKKENLNLKSFVNIAINSQQEINVMVLKLADRLDNIASIEFLPIEKQKVIAKETLELYAKIAGRIGMYPVKTKLADLSFKVLDLKNYDNTLSKINKQKVFYDNEWDNFKQQLKKILAQNQIEYQLESRIKGIYSTYKKLTVHEQNISKIHDLFAIRLITKSELDCYHILGLIHLNFLIDSKYFKDYIASPKQNLYQSIHTTVRLKGLNVEIQIRTQQMDNVSKFGLASHWIYKEQKEGLLAPALQLNYLVTKQKHSHDFLKRIFGTDIIKINVSASHEPNVIKQINVDSNNKLLDIAFENYPKQFAKLTKIEIDGVEINSFDTSVENEMLIEFYFGKNNNLKSKWIRYMNNPIYREKVKKSLAKLAKSGRYSELAFYEKELGEKQLKLASETEIQKRLNTLRIKKMSDYLALIECTNFTNDEHLLFLAKNNDKWNKLTKPLKFAFSKVVFHNSYFEQIEGIFITKIVIEPCCSKIPDMPEQVTGILTKNILSVHRYGCKNLQNKKQLKIIPLYWNIQQLKLKPRKFRSYININGVWSEKTINKICQTIINGDGYIEKIIPKINKQKDEFDLNITLFVNNYQQLLTLMDQITTKNISFSWKYL
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  This enzyme catalyzes the degradation of ppGpp into GDP.  It may also be capable of catalyzing the synthesis of ppGpp (By similarity).
What are the official names of this protein?
Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase, Penta-phosphate guanosine-3'-pyrophosphohydrolase, (ppGpp)ase.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: GUAA_ECO5E
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: P2C77_ARATH
Sequence: MDEVSPAVAVPFRPFTDPHAGLRGYCNGESRVTLPESSCSGDGAMKDSSFEINTRQDSLTSSSSAMAGVDISAGDEINGSDEFDPRSMNQSEKKVLSRTESRSLFEFKCVPLYGVTSICGRRPEMEDSVSTIPRFLQVSSSSLLDGRVTNGFNPHLSAHFFGVYDGHGGSQVANYCRERMHLALTEEIVKEKPEFCDGDTWQEKWKKALFNSFMRVDSEIETVAHAPETVGSTSVVAVVFPTHIFVANCGDSRAVLCRGKTPLALSVDHKPDRDDEAARIEAAGGKVIRWNGARVFGVLAMSRSIGDRYLKPSVIPDPEVTSVRRVKEDDCLILASDGLWDVMTNEEVCDLARKRILLWHKKNAMAGEALLPAEKRGEGKDPAAMSAAEYLSKMALQKGSKDNISVVVVDLKGIRKFKSKSLN
What is the function of this protein?
Repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), high light stress, response to glucose, seed germination and inhibition of vegetative growth.  During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as H(2)O(2) and oxidative burst in response to ABA and dehydration.  Represses GHR1 and, to some extent, SRK2E/OST1, kinases involved in the regulation of SLAC1-dependent stomatal closure (PubMed:22730405).  Controls negatively fibrillin that is involved in mediating ABA-induced photoprotection.  May be implicated in ABA content regulation.  Involved in acquired thermotolerance of root growth and seedling survival.  Required for the Erwinia amylovora harpin-induced (HrpN) drought tolerance.  Involved in the hydrotropic response.
What are the official names of this protein?
Protein phosphatase 2C 77, AtPP2C77, Protein ABSCISIC ACID-INSENSITIVE 2, Protein phosphatase 2C ABI2, PP2C ABI2.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: MED14_NEOFI
Sequence: MPGVIMDNATVGRLGHAPDTQTPSNGDNLRNGSLHINGAAKGDKDHDPDKESYTGKPKIDGHRALPELPHITQGFFPFSTLVNRYVQQCWNELSDLITELAAIQVSPHSSMPLLPANGKSPGNQSPENVQKKLRILDFAHAKRAEFIKLLVLSQWSRRAHDVSKLIDLQNFIRSRHQAFVDALQRVGEMKRDLVQAQVANPDLQTALEILSKGRLESLADLGYKSSKLLTARGALKRLHRINRIISARLALHDSIPHPFRTYRVHDGRVTFVVRGEFELDLSVGAESELSQFFFVDIRFLYSPSSNIPNGRMSNEIDAKINDKLRDSGLTGCFNFLHGLVLTNKIHILFKQAIELAKGLWSETLRVELLHRTLVIQYWALKPGPKSWVEIGVKSGNGDADSQGVGVPCLGLRWMRDGQEVDSRDIEFDPEDLSMECLLRSVIALHISYLLSSAYGILSEYSLFSTGTLSSQAILNVTEPGECQLSVQLTGSRHLRVSIEPMSGAVTLSATPGLSERSESDASLDRSTIDDLVARVSRLRCIAAIEELESNVRILGFETVSPKGLRNEIRTVFPANVLRFSLFWHPSWERNWVVAATSSITGDNWWVVQLRRSSEVATDFSVSDTSVPLCSGHSMSDTFLATSHQTRSSSFPDLGYCLSGMVAIYANVSYLSDLQSVEFHPPLCALKVESDLQIPDIFIRYQVSKLPRALQLVLPAGLKRKNLLKDTVRLAFHGIDRHKNSAIFVAYGNLVGPWTDLCTLVSKSDSSLVFKRGGSGFALRLLAPAGRPVIVQLFKSLQTLECTLSILDFLRQRRLTPQSLSLTHIAFAYGPRRDLSAIIGIGLSEVPSSAELDPVRILARTDPLLFLTLGIRFKHPNPHRRVQGSLAAILNHASNEAGLDFVTEILSFTLPLMRALEQITSNASRQESFRLQVIVRNACTFLLHYTYQGFRFQLTTSQHSGQLTWVLRELSSPGAGPGHDQLKARLRGTLYHSNGNGWKGLGNGVVADVEGVSNVIWALDGCFTGAQHNTWLPRETKSDQDYSTQPVPEKQSQTGAPSQAAMANDTTITANFVNDKSLQRNPVASNAADVITID
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LACG_STRPC
Sequence: MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYTAEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVNYAELCFKEFSEVNYWTTFNEIGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDSGYSGEIGVVHALPTKYPFDANNPDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDLREEDFAALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDVPKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVKKHLEVISDAISDGANVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWYKKVAETQVIE
What are the official names of this protein?
6-phospho-beta-galactosidase, Beta-D-phosphogalactoside galactohydrolase, PGALase, P-beta-Gal, PBG.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: TSAD_YERPY
Sequence: MRVLGIETSCDETGIAVYDDKAGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKEANLSAKDIDAVAYTAGPGLVGALLVGATIGRALAFAWGVPAVPVHHMEGHLLAPMLEENAPEFPFVALLVSGGHTQLISVTGIGEYLLLGESVDDAAGEAFDKTAKLLGLDYPGGPMLSRMAQQGTVGRFTFPRPMTDRPGLDFSFSGLKTFAANTIRANGDDDQTRADIARAFEDAVVDTLAIKSKRALDQTGFKRLVIAGGVSANQTLRLKLADMMQKRGGEVFYARPEFCTDNGAMIAYAGMVRLRSNLNSELSVSVRPRWPLSELPKV
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHAG_RHIME
Sequence: MSHLTDLPPWAALLVCGLMLVGAATTLIGSLGLLRLPDFYARLHAPTIATSGGTILLCLASILCFAVLQSRWVFHEVLIIFFVTVTTPVTLMLLGQATLYRDRFEEQQGVPRKQKPAPGEE
What is the function of this protein?
Part of a K(+) efflux system which is required for the adaptation of R. meliloti to alkaline pH as well as for the infection process during symbiotic nodule development.
What are the official names of this protein?
Probable K(+)/H(+) antiporter subunit G, pH adaptation potassium efflux system protein G, Pha system subunit G.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PP1A_MOUSE
Sequence: MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIRYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
What is the function of this protein?
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets.  Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.  Involved in regulation of ionic conductances and long-term synaptic plasticity.  May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.  Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.  Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.  Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development.  In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.  May dephosphorylate CSNK1D and CSNK1E.  Dephosphorylates CENPA (By similarity).  Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PP-1A.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles (By similarity).
Protein: PKS21_DICDI
Sequence: MKLENKEIAIVGIGFRIPQGKESINNGSVSHLWNNLKNGFSGIVETSERWSDNINLLGEVNNKFGGLLPLKEWSDFDPVHFAINPSEVPLMDPQTRLLLKCTWEALEDAFIDPIDIRGSNTSCFIGCSTLDYSTTNRDFNETSENYFASNVLHTISNRLSFSYDIRGPSMTIDTACSSSLNSIAMGFQSIQNGTSNLSIVGGVSLLLDPYISKSFSFLNMLSKKGKCKPFDSEADGYIRAESCGIVILKPLSDAIRDGNNIYCVINSFSSNVDGGGLNDKSNFYSPSKQSQSDNIKLALKSANMKASDISFVECHGTGTPTGDPIEVEGVSMALNSSKTSTPSKPLLIGSLKSNIGHSEAASGVASLIKCCLMFKNKHYAPNVNFDQPNPKINFKDWNIKVVTEAIPFTNNNEKPVSMVINNFGVTGSNCCLILSQFIEQSINQNGNGHSYPAESQQQQQQRFLIPFSANSVKSLKNYEDLIINDIKISTNSFKEFVKNQIYSKSKKLYQRSVLISSNWDQLKTKNKYFKTNNDKSSNITIKRNQPLVVIVFGGQGSQWNKMAQQLYECEPIFRSSMDKFNKELSKYYGYSVLDKLRSIKDDDIISIHQPIIAQPSILMLQISLFELYKHWGINVSFIVGHSLGEIATSYCSGMVDFQTVCKLIYHRSISQNNTNGCGKMLSVNISHSEFIELYSNKYPTIEVACYNSPTSIVIAGNENILKEISLNLKENNIFCAFLGSLSSFHTSSQHSTKNEILPLDIPSKQSRIPTFSTVTTNLFNHETTPFNSSYVYENIIQPVRFSQTISNLYQHIENNKLGNELIFIEVSPHPSLSFYLKQMIPKSSSYFNSVSVLTSTNKKNSNDLDEIHSTISQIYCLGYDVNFKCQFNHNDDDVSSIRNSKVNISLPNYQFDEQHYWKVDINFEQYRLNGPNVFNSLGKSMINYSSNNKSYESIIDINRNPFKYLKDHIVKGKYYFPGIGYADNIMKLYPNQDIIINNLEFLAPFVLKENVKHTLQTNVYQLGNTDYRVTFNIKDNKTNQWVQTCTGNFQLISLKDNNNDHSSKYDINQLLSECNFTTLSKQEVYKHSRSITGITHLGAFQGIEELYFGNDCIISKIQVNTENFDIDGKPVYQTYDKSFFNTALLDSCSQTIVGFITNSSQFVFERLEGLKVYSENIPTDKLKYKNIYCQAKFISLESDSYKSSVLVLLEDGTKLLEMDCISLHSTLPLLNSLLINNPTTELFTNNLQCKDSLVNILSIDNNQTFSSISSSNTVTEIIKQTIKPIINEKIVFRILQSFSDLELSKQIIETLNQIFDDNSLQEIDIEFTIIDNSNDKLPTLHDSSLIFKNDITQLKPSYYDIIINNNNDGDDETIIKSIFNILSSNGLLLIIGDDIGDKYNIDSLINLGFNENKIQKSNKVIQSQKSTILSNELTVVPNNKNDNIIIYCEKESKYTNEFMKLISNNHISCKQTIISNINEFNQLLPSITNDSIIYFIKSMEQLEMNNFKQITMEYIEINQQLLKHSLTCKHVLITIDSQIKNYLSSSIIGTARYFNEFPSLNLYSIDFDNQLSISSLLNKIINQLIENSNNHIQREYIIRNNSIYYEILKNEKNIKSNFNSNSFEDNDFMTLLDSTNLEYKLASKPKKLKKNQIEVKVLATGINYKDYLIYRGLVVIDENVSISKNPLGLEFSGIITRISNENQNCEFKVGDNVFGIACDTTASHVIADVLYVSHKPENISHVEAASLPVIFSTCLHGMFNIGNFNIDDDEVILIHSATGGIGLATLEILKWKGHKSPIFVTVGSKDKEQYLIDNYGSFITGIYSSRNKNYVNEIKSKLNQLYGTTGKFNGVDLIINTLPNEFTHSNFLCLKERGKIIDLSITHLNNNEFLNFNNFKFNKSYHNIELMHINKKVVSRLLKSISNALNENKLKPIPITTFQIEDVKEAIEYINQRKHIGKIVLDHSCSNGSIGSDGLLNQLIESDNNEKNHTILKYDFKIDTKNIIGKNIIITGQSGIILEILKWLIKYSPTESFENIIILSKSSLKWELELLINKTISRKDNNTKFHFKSVDVGDPIEMRKSINQILLENPNIDNIDSIFHYAFAQITKEVEEIDIESLDISHNAKTMGAINLHEISIEKSWKLKQFVMASSIASLFGSFNQCSYVSANLVLDSLSRYRKSIGLPSTCTNWGAIKSAGFVSRNELVSKMLDDQGFIPIPTNIILGSLDLQLQNSNKNSNLIVSKFNYDSIKKLSSETSTFQRLDFILNSIKEKDNDSNGGENSVSESIQTKILNKISELLSIEQSKINTDIRLSDYGADSLTSVQLKNFIDKDIKSNVITLQQLQNNTIDMNIQTILEQIKKLDSNETKGKSKNIIKKDSAPTLDYWRNEMKLDESIQAIKMNPIDFRNDSKVFLTGATGFLGVHLLSNLIKSPNCSVVYCLIRNKKSEPNPINAIINNLKHHKLYHFHNEFELSKIKVIVGNLASPLLGLSKLDFDYISNQINLIINSGADINLASNYEESKVVNIGGFIELIKLSTTGDYQKPIVGFSSVSVFFNASNCKEFDEETVIPTIENINNLPGGYMKSKVVVENLLREVAKRGIPSMLIRPPIIFSHEETGIGHDSDFFQLIIQSCYAVKKYPKIDKNILTSPIGWISLNTIKMIGNEKCWNKSSSNQLNIYSLNSEVSAMNPSFSFLEKQYGCEMVEYEQWKNIINQSKILSCVKLKTFHSLDDLYNIYNLGNGFGVSKKTKELLQSMNSYEGGMVNEKMIQNHINYIFKN
What is the function of this protein?
Probable polyketide synthase.
What are the official names of this protein?
Probable polyketide synthase 21, dipks21.
Protein: YAFD_SALHS
Sequence: MRKNTYAMRYVAGQPAERILPPGSFASIGQALPAGEPLSSEERIRILVWNIFKQQRAEWLSVLKNYGKDAHLVLLQEAQTTPELVQFATANYLAADQVPAFVLPQHPSGVMTLSAAHPVYCCPLREREPILRLAKSALVTVYPLPDTRLLMVVNVHAVNFSLGVDVYSKQLLPIGDQIAHHSGPVIMAGDFNAWSRPRMNALYRFAREMSLRQVRFTDDQRRRAFGRPLDFVFYRGLNVNEASVLVTRASDHNPLLVEFSPGKPEQ
What are the official names of this protein?
UPF0294 protein YafD.
What is the protein family that this protein belongs to?
Belongs to the UPF0294 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSKIP_CHICK
Sequence: METDCSPMELTNNTESEEDSDYRDFEEADVKDMRLEAEAVVNDVLFAVSNMFVSKTLPCAEDVAYINVETRERGRYCVELTDSGLRVVAYDFDQTDDSLQNPYHETVYSLLDTLSPAYREVFGNALLQRLEALKRDSQS
What are the official names of this protein?
GSK3-beta interaction protein, GSKIP.
What is the protein family that this protein belongs to?
Belongs to the GSKIP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYAR_HUMAN
Sequence: MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGGKGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNKKISKNPTFKLLKDKVKLVK
What is the function of this protein?
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227).  Also acts at the level of transcription regulation.  Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918).  In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580).  Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918).  Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131).  In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (PubMed:31413131).  Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity).  Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).
What are the official names of this protein?
Cell growth-regulating nucleolar protein.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cytoplasm. Cell projection, cilium, photoreceptor outer segment. Note=Component of pre- ribosomal particles, including pre-40S, pre-60S and pre-90S (PubMed:24495227). Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247). In the retina, predominantly expressed in photoreceptor outer segments (By similarity). In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity).