PharMolix/UniProtQA huggingface dataset:
Protein: MFF_HUMAN
Sequence: MSKGTSSDTSLGRVSRAAFPSPTAAEMAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQEGVPNASVIMQVPERIVVAGNNEDVSFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPPTTPQNEEIRAVGRLKRERSMSENAVRQNGQLVRNDSLWHRSDSAPRNKISRFQAPISAPEYTVTPSPQQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVRYGISNIDTTIEGTSDDLTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR
What is the function of this protein?
Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833).  Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241).  May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity).
What are the official names of this protein?
Mitochondrial fission factor.
What is the protein family that this protein belongs to?
Belongs to the Tango11 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Protein: DUT_MYCSK
Sequence: MSTSLAVLRLDRELPMPARAHDGDAGVDLFSARDVELAPGQRELVPTGIAVAIPHGMVGLVHPRSGLAARVGLSIVNSPGTIDAGYRGEIKVSLINLDPHAPIVIRRGDRIAQLLVQRVELPELVEVTSFDEAGLAETTRGEGGHGSSGGHASL
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RS3A1_YEAST
Sequence: MAVGKNKRLSKGKKGQKKRVVDPFTRKEWFDIKAPSTFENRNVGKTLVNKSTGLKSASDALKGRVVEVCLADLQGSEDHSFRKIKLRVDEVQGKNLLTNFHGMDFTTDKLRSMVRKWQTLIEANVTVKTSDDYVLRIFAIAFTRKQANQVKRHSYAQSSHIRAIRKVISEILTKEVQGSTLAQLTSKLIPEVINKEIENATKDIFPLQNIHVRKVKLLKQPKFDVGALMALHGEGSGEEKGKKVTGFKDEVLETV
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
40S ribosomal protein S1-A, RP10A, Small ribosomal subunit protein eS1-A.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: BETA_YERPY
Sequence: MEYDYIIIGAGSAGNVLAARLTEDADVTVLLLEAGGPDYRLDFRTQMPAALAFPLQGKRYNWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDHWASLSGLEDWSYLDCLPYFRKAETRDIGPNDFHGGEGPVNVTTPKIGNNPLFHAMVAAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARPRNNLTIITHALTDRILFEGKRATGVRYLKGDAGTGQTAYARREVLLCGGAIASPQILQRSGIGPAELLQRLDIPLVQALPGVGENLQDHLEMYLQYSCKQPVSLYPALLWFNQPKIGIEWLFNGTGVGASNQFEAGGFIRSRDAFTWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIQVKSKDPRQHPSILFNYMSSEQDWHEFRDAIRITREIIAQPALDPYRGREISPGANVQNDDELDAFIREHAETAYHPSCSCKMGDDKMAVVDGQGRVHGVQGLRVVDASIMPQIITGNLNATTIMIAEKIADRIRGCQPLAKSNAAYFIAGDTPARTSPVRHSLPVTSYP
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: GLYCO_VSIVG
Sequence: MKCFLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTGLQVKMPKSHKAIQADGWMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESIEQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGKCSNDICPTVHNSTTWHSDYKVKGLCDSNLISTDITFFSEDRELSSLGKEGTGFRSNYFAYETGDKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTSVDVSLIQDVERILDYSLCQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKYFETRYIRVDIAAPILSRMVGMISGTTTERELWDDWAPYEDVEIGPNGVLRTSSGYKFPLYMIGHGMLDSGLHLSSKAQVFEHPHIQDAASQLPDDEILFFGDTGLSKNPIDFVEGWFSSWKSSIASFFFIIGLIIGLFLVLRVGIYLYIKLKHTKKRQIYTDIEMNRLGR
What is the function of this protein?
Attaches the virus to host cellular receptor, inducing clathrin-dependent endocytosis of the virion.  In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and endosomal membrane.  In neurons, neo-synthesized glycoproteins are sorted to the dendrites, where the virus buds (By similarity).
What are the official names of this protein?
Glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the vesiculovirus glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host membrane; Single-pass type I membrane protein. Note=The cytoplasmic domain sorts the protein to neurons dentrites instead of axons. When expressed in ex vivo polarized cells like epithelial cells, it sorts the protein to the basolateral side (By similarity).
Protein: RNF11_BOVIN
Sequence: MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPVYHPTPSQTRLATQLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN
What is the function of this protein?
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways.  Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation.  TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains.  This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B.  Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome (By similarity).
What are the official names of this protein?
RING finger protein 11.
What are the subcellular locations of this protein?
Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1.
Protein: TRMA_ECOL5
Sequence: MTPEHLPTEQYEAQLAEKVVRLQSMMAPFSDLVPEVFRSPVSHYRMRAEFRIWHDGDDLYHIIFDQQTKSRIRVDSFPAASELINQLMTAMIAGVRNNPILRHKLFQIDYLTTLSNQAVVSLLYHKKLDDEWRQQAEALRDALRAQNLNVHLIGRATKTKIALDQDYIDERLPIAGKEMIYRQVENSFTQPNAAMNIQMLEWALDVTKGSKGDLLELYCGNGNFSLALARNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKSYQCETIFVDPPRSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHKVERLALFDQFPYTHHMECGVLLTAK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: FPG_SHESW
Sequence: MPELPEVEVTRQGIAPYLVEQTVIDLVIRNGSLRWPVPDIAKQIIGQVIRQVRRRAKYLLIDTDAGTSIVHLGMSGSLRILPHDTPVEKHDHIDLVLANGRILRFNDPRRFGAWLWCELPEEAHPLLAKLGPEPLTNAFNVKQLAAALTGKKKAIKLCLMDNHIVVGVGNIYANEALFAAGIHPEAEAGKIDIERLTVLVAEVKQILAHAIKQGGTTLKDFTNADGKPGYFAQKLHVYGRGGETCTSCGNLLSEIRLGQRTTVFCGICQTR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: GRAR_STAHJ
Sequence: MQVLLVEDDQTLFQELKKELEHWDFFVTGIDDFSAVMDIYEETNPEIVIMDVQLPKYDGFYWCRKIRQVSNVPILFLSSRDNPMDQVMSMELGADDYMQKPFHTNVLIAKLQAIYRRVYEFGAEEKRTLNWQDALVDLSKDSIQKGDSVIYLSKTEMIILEMLIQKQNQIVTRDTLITALWDDEAFVSDNTLTVNVNRLRKKLSDIGMDTQIETKVGKGYMAHE
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).
What are the official names of this protein?
Response regulator protein GraR, Glycopeptide resistance-associated protein R.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR_MYCPU
Sequence: MAKVLVIKTSMMGANSISNVLNDKFMEYYKEKNPNDEFIYMNLNDEKMASITMTSHNMKEYFVAEYSDKYINQLKKVDKVVMSVPMTNFNVNAVTKNYLDHISVADKTFSYKYSKKGEAIGLLDHLSVQILTTQGAPLGWYPWGNHSEYLKGHWRFLGAKVADHILVDSVKIGENSKKTPQEIIEKFDGEIKKAAYSF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RL28_FRASN
Sequence: MSSVCDVCGKGPGFGMSVSHSHRRTRRRWNPNIQTVRAMVGRTPRRLNVCTSCLKAGKVTRG
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: DXR_ECOLI
Sequence: MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTILLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFNASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALNLSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: Y1273_AZOVD
Sequence: MSEFHQDLSEEKSKSQVKRELHALQELGERLAGLRPEQLDRLPLTDALRRALLDAPKHTAHIARKRHIQYIGKLMRDQDIDAILALFEQLDASSRQYNERFHALERWRDRLLDGGDEALEAFVGDYPDTDRQHLRGLIRQARHETAQNKPPAASRKIFKYIRDLDESRRGLR
What are the official names of this protein?
UPF0307 protein Avin_12730.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: RL331_MESFL
Sequence: MHKTKSTRKIILVCEDCLSRNYSLNKSNLTQKERLEIKKFCSMCNKHTLHKETR
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RADA_HALSA
Sequence: MPESDLEELPGVGPATAEKLRDNGFDAFQSLAVANSAELSNTADIGESTAADVIQAAREAADVGGFETGATVLERREQIGKLTWNIPEVDDLLGGGVETQSITEVYGEFGAGKSQVTHQLAVNVQLPTEYGGLHGRAVFIDSEDTFRPERIDDMVRGLSDETLQAAMEAHEIEGSTDDEDTLTELVDAFLDKIHVAKGFNSNHQMLLAEKAKEIASEHEDGDWPVRMLTVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLEKVGNLYNAAVLVTNQVQSNPDAFFGDPTKPIGGNILGHKSTFRMYLRKSKNDKRIVKLVDAPNLADGEAVMRVQDEGLKPE
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  Binds and assemble on single-stranded DNA to form a nucleoprotein filament.  Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).
What are the official names of this protein?
DNA repair and recombination protein RadA.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family.
Protein: PRSA_STRS7
Sequence: MKKSTKLLAGIVTLASAMTLAACQSTNDNTSVITMKGDTISVSDFYNETKNTEVSQRAMLNLVVSRVFEDQYGKKVSKKKTEEAYNKSAEQYGASFSAALAQSGLTTDTYKRQIRSAMLVEYAVKEAAKKELTDADYKKAYESYTPEMTTQVITLDNEETAKAILGEVKAEGADFAAIAKEKTTAADKKVDYKFDSGDTKLPADVIKAASGLKEGDISEVVSVLDPATYQNKFYIVKVTKKAEKASDWKKYKKRLKEIVLAEKTQNIDFQNKVIAKALDKANVKIKDQAFANILAQYANTDKKASKANTSKSDQKTSSDSSKDSQSSKSKSEK
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: FABA_SHISS
Sequence: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_SHIB3
Sequence: MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTDRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRESVTAGQLAIENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLDELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGEADVGSFITALNLAIKMIVNTQ
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAE2_HUMAN
Sequence: MADNLPTEFDVVIIGTGLPESILAAACSRSGQRVLHIDSRSYYGGNWASFSFSGLLSWLKEYQQNNDIGEESTVVWQDLIHETEEAITLRKKDETIQHTEAFCYASQDMEDNVEEIGALQKNPSLGVSNTFTEVLDSALPEESQLSYFNSDEMPAKHTQKSDTEISLEVTDVEESVEKEKYCGDKTCMHTVSDKDGDKDESKSTVEDKADEPIRNRITYSQIVKEGRRFNIDLVSKLLYSQGLLIDLLIKSDVSRYVEFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLEYEQHPDEYQAFRQCSFSEYLKTKKLTPNLQHFVLHSIAMTSESSCTTIDGLNATKNFLQCLGRFGNTPFLFPLYGQGEIPQGFCRMCAVFGGIYCLRHKVQCFVVDKESGRCKAIIDHFGQRINAKYFIVEDSYLSEETCSNVQYKQISRAVLITDQSILKTDLDQQTSILIVPPAEPGACAVRVTELCSSTMTCMKDTYLVHLTCSSSKTAREDLESVVKKLFTPYTETEINEEELTKPRLLWALYFNMRDSSGISRSSYNGLPSNVYVCSGPDCGLGNEHAVKQAETLFQEIFPTEEFCPPPPNPEDIIFDGDDKQPEAPGTNNVVMAKLESSEESKNLESPEKHLQN
What is the function of this protein?
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex.  Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B.  The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.  Less effective than CHM in supporting prenylation of Rab3 family.
What are the official names of this protein?
Rab proteins geranylgeranyltransferase component A 2, Choroideremia-like protein, Rab escort protein 2, REP-2.
What is the protein family that this protein belongs to?
Belongs to the Rab GDI family.
Protein: RL331_GEOTN
Sequence: MRQKVTLACEQCGSRNYTTTKQMGRLGERLTANKFCSVCNKHTVHRETK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: ISPE_HELPY
Sequence: MTHVFEVYPKVNIFLKILHKEGAYHKLISRMCLVKDKLKDIISVKSALSFSLKGDFDCPLEENSLFKALQILKNFLKSKNFSHSVIKSLDTLAIEVEKNIPTQAGLGGGSTDAGGLLYHLNQIFDWRLSLEELYSMGSLVGADTNFFISQYKSTNATSYGEVIENFEEEPLENRLEIYAPNHVFCSTKAVYQAYKPETCFSQAKEWLKKPSLECLKTYDRNGLNDLLKPALLTNQALKDIESELGKEWFFSGSGSAFFRLKPMQKGGE
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: CHIO_RAT
Sequence: MLCTSPVNCLDSVCCTSINISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANIYPDINIITGALKLYFRDLPIPIITYDTYTKFIEAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNLMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF
What is the function of this protein?
GTPase-activating protein for p21-rac.
What are the official names of this protein?
Beta-chimaerin, Beta-chimerin, Rho GTPase-activating protein 3.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: MDHA_DICDI
Sequence: MEQAILRINNISSQLTGKCPFKAHGGGAGKCPYKLGGGQILDQSKAWSLVNVTANVDQVTPIKVLVTGAAGQIAYSLMFMIASGQMFGPHQPVILHLLDIPKMADALKGVVMELQDCSYPLLQSVVATTDIQTAFLHINVAILVGAFPRGPGMQRKDLLKVNVSIFKEQGEALNKYASRGVKVLVVGNPANTNALTALMKASDLPTSNFSALTRLDQNRAQSMISEKVGTNVDNVHNVIIWGNHSQTQVPDVNHGYILNYPNRGLIEPIPSSVNDDKWLNEQFIPLVQNRGATVIAARKLSSAASAANAIVGHVRDWLLGTKDGEHVSMAVYSDGSYNVPKGLIFSFPVTCHNGQWTIVQGLKINSSTQQKIDATIKELQEEKETAMSFLN
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Probable malate dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: LIPA_SYNC1
Sequence: MDVGQKKRGADKTALATTDEQGALSKPTWIRAKAPISPEVGRLTGILRDLHLHTVCEEASCPNLGECFKRGTATFMIMGDVCTRRCPFCDVAHGRPAALDTEEPGHLADAIGAMKLKYVVITSVTRDDLEDGGAAHFAQCIESIRKKTEGVKVEILVPDFRGHVDAALKNLGNCLPDVFNHNLETVPRLYAESRPGARYHESLRLLQRFKETYPGIPTKSGLMLGLGETDEEILEVMRDLRVHGCDMLTIGQYLRPSRHHLPVQRYVTPEQFEAFRVAGLKMGFSQVASGPLVRSSYHADLQAKEVLHT
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUSG_ASPCI
Sequence: MAMGNPGLWTHFSRSPRELRIPNDLELPNGLLVVCGLPGLLLLFFVTAILLYPFRNKSDLPLINPGKGRIGILRGYRARKTFAAELPRLVTEGLSKASAFRIAAPDGVNIVLAPRYAHEIAEHPDLNPGPIAGDEFNCHIDGFEVFAQLGTSDVIAESVRTRLTRQLTKLTPLLTTETPLLLQSQWKDAPTWVEVSPHETALFILSRLSSLVFVGDDLGRNPDWVHILTSYNTEAFAAAQELNLWPQILRPLVARLKPSCRQLRRYIRDARALLVPVIEQRRHAQSHGDRREYNDAIEWLDQTSRSAGQPYDPLLSQMLLAIGSFHTSSDLLGQVLLDLCSRRDWEVLARELRKEIISSLQGAGWDKIALNNLKLMDSVLKESQRLKPASTVTMGRYASREIRLSDGTAIPKGSTVFIANVAMRDPKIYPEPDAFIPDRFTTRREKGDSSAYLVSASPEHIGFGLGRHACPGRFFAANEVKIVLSHMLLKYDIKFPDNGAAAPSTSGIFLETNPDARICVRRRKEEIVI
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Cytochrome P450 monooxygenase ausG, Austinoid biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: KEFG_ECOHS
Sequence: MMSQPAKVLLLYAHPESQDSVANRVLLKPATQLSNVTVHDLYAHYPDFFIDIPREQALLREHEVIVFQHPLYTYSCPALLKEWLDRVLSRGFASGPGGNQLAGKYWRSVITTGEPESAYRYDALNRYPMSDVLRPFELAAGMCRMHWLSPIIIYWARRQSAQELASHARAYGDWLANPLSPGGR
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefB.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefG, Putative quinone oxidoreductase KefG.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.