PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_LEPBL
Sequence: MSKKKKTYQNTLSEKEAKKVIAKLADEIRHHQYLYYVKNQPEISDFDFDQLFKRLRDLEEEFPQFKDLNSPTLVVGSDLDKDFEKFQHKLPVLSLINTYNDDELLDWVNKTDPDGLYSVEWKIDGASIVLYYENGMLKNGVTRGSGGIGDDVTDNIRTVRNIPLRLPEPITVYLRGEVFMTFKDFEEFNELSSGKYANPRNLSAGSIKQKNSADTAKRPLRIFTYDATFPGFTKKFKTHQQILSKLEKLTFPVPPDTVFVNGSKIAETIKDFKKKKDTLGFPTDGLVIKLNDISKRDAQGYTSHSPRWARAYKFDAIMKESRIVDITYAVGRTGKITPRVEIEPVNLAGTTVTFATLHNQDYIDELGVGIGAIVRVAKRGEIIPAVEEVITPGKDVFKIPDYCPSCKTKTIKKENLVDLFCPNPDCPDRVKNGIIFYCQRKQMDIEGLGDKQIEFLYDHGYIRSIADLYDLKDQKEKLIEEEGFGEKSLAIIFNGIEHSKQKDFRFLLPSIGLPELGHKVTELLIEHGIDSIDEILSIAKDKKRISSLLEIPGIGPSTIKAFEENFSDKRILKLIARLKNAGLKLKADPIKVSDQQPFAGQSWCVTGSFENFQPRDKAMDLVVYYGGRKVSAVSSKTTHLLAGPGAGSKLEKANELGIVVYNEKQFLDLLKSLKINFKNTI
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: MECA_STAAS
Sequence: MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPLWIQVHAFEKGVEVTISKSKNEDMMNMSDDDATDQFDEQVQELLAQTLEGEDQLEELFEQRTKEKEAQGSKRQKSSARKNTRTIIVKFNDLEDVINYAYHSNPITTEFEDLLYMVDGTYYYAVHFDSHVDQEVINDSYSQLLEFAYPTDRTEVYLNDYAKIIMSHNVTAQVRRYFPETTE
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: RS17_THET2
Sequence: MPKKVLTGVVVSDKMQKTVTVLVERQFPHPLYGKVIKRSKKYLAHDPEEKYKLGDVVEIIESRPISKRKRFRVLRLVESGRMDLVEKYLIRRQNYQSLSKRGGKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: CMC4_CLAL4
Sequence: MSKPESCDENACKPFACAIQDCLIENGYNESKCTKAIDNLYKCCKQFYEENGPDAASVCCPKFNLLQLKLKQRSLGKIDAELIQSRK
What are the official names of this protein?
Cx9C motif-containing protein 4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the CMC4 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Imported into the mitochondria via the mitochondrial disulfide relay system.
Protein: SGD1_YEAST
Sequence: MQKTDGIRIPGVILDELKTLDYSQDERFSISEGKKRRRGNGKHLSRKEKRKMERADKKRKIISTREINSSRLKSAPTSEKRSANAGVKNVGKQANGKNPISSDESESNENWDSDEVLTDEVAEESGEQAMSAEETMKKLESLKRKAKGIQGAENSGEIKGNSYEKKHIRNRDTNENFVSYPLAPSDRSAFERDEMDMQYYAKKLGLKGERKAIHAKDEFDAIGGLLEGLEYFENYGKSDEEYGDFATETNSMRKDDEASEKAFSSDDDLSASDFEDSDGLSESDNDSVADSDDNYRREKENPYVAPTQSVESYVPPSLRKKLDDSENNSTLSEISKKVNSSLNKLSDSNITIIITDLNRLYDSLPRQYVTESLTKGILNIISQNQKLLDGFIMNYAALAYTLSKLRGIEVGAFFIQKTVEAFLHHYEEEMENILKDQQSKISSKICINIATLLSYCYNFGFVSCRLIYDIIRIFVADPNEFTTELLLRIISISGQLIRGDDPSALRDIRSELLKNAKNLKEQSPRLRFLMDTMSDLKNNRLKPSILATDHHPLKKNLQSILNSSSSWEPLQVSLEDIKNIDSKGKWWLVGASWRGNMENAFEVSINNENDASKSKKSKISIEDDLLDDIPDWNIIARQQRMNTDIRRAIFISIMSAQDYLDAFSKLEKLSLKNKQVLEIPRIVLHCLLADSGSNGYNHYYALVANKICERYSHLSKSFQFLFWDVIKKFEDKEFDSESDTDEEDDLDDKEKLLRISNQGRFFGSLLANDILKLDVFKHVPFMGGLNTEGMLFMEILLFQLFLTVAKKSEKKLKMDESGNKRIIYSDDYLRDVLTKNVKSENMLFILKGLKWFINKKFRYHNFLAGKKGDKAFDRDERRLAWASKAAKSIIDKELENIDS
What is the function of this protein?
Involved in osmoregulatory glycerol response, probably through its interaction with PLC1 which regulates the expression of GDP1.
What are the official names of this protein?
Suppressor of glycerol defect protein 1.
What is the protein family that this protein belongs to?
Belongs to the CWC22 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NU3C_SYNY3
Sequence: MFVLTGYEYFLGFLFICSLVPVLALTASKLLRPRDGGPERQTTYESGMEPIGGAWIQFNIRYYMFALVFVVFDVETVFLYPWAVAFNQLGLLAFVEALIFIAILVVALVYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi- pass membrane protein.
Protein: MTAD_ACET2
Sequence: MNILIKNADIITCNASDDVLQGAFLGIKDGYIDFIDTKEDALKDFKADRIIDAKGKLVMPGLVNAHTHSGMTILRNFANDLALEDWLFGNVLPVEEKLTPEDIYWGTLLGIAEMIKSGTTTFADMYLHMEEVARAVSETGIRANLCRSPLKDSDKSVEDAVRCFEYFKKWDNSFNGRIKVYIEVHSVYLFDEPSLRMSAEVAKEINTGIHIHVQETLKECEDSNKKYGMSPAEICCKTGIFDVPVIAAHCVHLSDGDMGIIRDKGVNVIHNPTSNLKLGSGIAKVDDMLKNGINVALGTDGAASNNNLNMFEEMHLAALIHKGVHMDPTLIGASCALKMATVNGAKALGFGGEIGEISKGMKADLILIDMDKTHLCPVNDPVSAVVYSAQSSDVDTVIIDGNIVMENRELKTIDEEKVKFNVKEIAKRVLR
What is the function of this protein?
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively.  Is also able to deaminate adenosine.
What are the official names of this protein?
5-methylthioadenosine/S-adenosylhomocysteine deaminase, MTA/SAH deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Protein: RSMC_SHEHH
Sequence: MLTNASQVLLRNRDLVKDQSVLVLNYEGDHLPKELLNTARSVCGLALDYHHHLMMQPYAAANLTLHFGHQLPNDESFDTVIVYFPKAKALAPYLFNLAAKHLKPQGQLIVVGENKGGIKSLPKQLPSYFDKPFKADNARHCIVFLSELNAAAPTLKLTDWISRYQLDTPQGQVTICNLVGVFSEKKLDEGTKLLLENLPKMRGKVLDFGCGAGVIAAALLKAQPELTLECVDINAMALASCEFTLQANGFNAKIFASDGLAQAAGRYDGIISNPPFHDGLASTTNIATNFVKDSAANLTTGGLFHIVANRHLPYSDTIAEHFGSVDVTAENNKYKIYSNVK
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEN5B_DANRE
Sequence: MSATMSGSGSAPCRFAHYFIVCGLDDETGLEPDALAALYQWLEADRQGKDPEATAAGENFDQSPLKRTFKSKVLAHYPENIECNPFDQDAVNMLCMPKGLSFRTQRDSLAPHFHSFLITREDGSRTYGFVHTFYEEVTSPQICSAMQTLHQMHQAEHNTSAQNCTSSSSSSSSSSSSSSMDSLSSSLDDVDSPSAHGGRRTCEGYDSIRDTLYVSKAMCLIAPMPFMHACKRFLAQMHRAVSCSPPPPLPLESYIYNVLYEVPLPASGRSLKFHGVYEPILCQRPGVGELPLADFPLADAFRLLGVENLVQLFTCVLLEMQILLYSQDYQRLMVVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHCIELPEDFPQFPNRSEFIQELSEVLLSFGQSPEGGSSSPEPAVMSLQTSVLEKELKSTSLRELVDDKTNGNLGGEALDVLELLQGNPTLERLQALAKRTGVKVARLEALAAGQKGDEGVGGRSPVEEEELRNAKLNVQLREVFAARFATMFADYESFVIQNSPDLESWLTNREQMHNFDKASFLSDQPEPYLPFLSHFIETQMFATFIDNKIMSQWEEKEPLLRVFDGRIEKARLYNVRAPSLRSSVYQKCTFLKESAQAIEQRLRKIDHTAIHPHLLDMKIGQGKYQQGFFPKLQADVLASGPTSNKWSNRTCSTQRRVERHRQQNEHLVLDNELKEKYMQEARNLGKNLRQPKLSDLSPAVIAQTNWKFVEGLLKECKMKTKRMLVEKMGREAVELGHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQAREEKNEQQLESPVSNGQERRKTESSVGLPGLRVSVIQDMRHIQNMAEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQALTKKLYKRYAFLRCEEEKEQFLFHLLSLNAVDYFCFTSVFTTIMIPYRAVIIPIKKLSNAMTTSNPWLCVSGELGDSGILQITKNILEMTFDCQNLGKLTTVQLGHDNSGLLAKWLVDCVMVRNEITGHTYKFPCGRWLGKGVDDGSLERVLIGEFVVPCGDDEGGRGSKTPPLQRSPSQIRRISITSLTGKGNKPTTVQIQESIGEAVNNIIKHFHKPEKERGSLTVLLCGEGGLVWALEQFFHHGFRSARIFQKNVFVWDFFERIVAFMENRDQTGDLQESPEPLSLNSESLCRYVNAINNMPRNIGKDGKFQLLVCLGARDRLLPQWLPLLAESPVITRMYEENALLRDKLTVSSLLGVLETLHDFPITLETSLTKSVEL
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) which may activate the small GTPases Rab.  May promote the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity).
What are the official names of this protein?
DENN domain-containing protein 5B, Rab6IP1-like protein.
What is the protein family that this protein belongs to?
Belongs to the RAB6IP1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: UC18_MAIZE
Sequence: DVHSNTGIFGIHTS
What are the official names of this protein?
Unknown protein from spot 263 of 2D-PAGE of etiolated coleoptile.
Protein: SURE_HELPH
Sequence: MKKILLTNDDGYHAKGIKALEQALEEMAEIYVVAPKHEKSACSQCITITAPLRAEKIKGKEGRHYRIDDGTPSDCVYLAINELFKHVCFDLVISGINLGSNMGEDTIYSGTVAGAIEGTIQGVPSIAISQILSNKNKNTPLSFDLAQKIIQDLVQNIFTKGYPLKGRKLLNVNVPNCSLQEYQGERITPKGYRLYKKEVHKRTDPKNESYFWLGLHPLEWQKRENEDRLSDFDAIASNHVSITPLNLDLTSYDDLKSLESWHEGMLK
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSC_THEVB
Sequence: MSANFLIQTVSNTPENILWHQSTVTRARREQLNGHKSYVLWFTGLSGAGKSRLAHTVEERLHRLGCRTFVLDGDNVRHGLCSDLDFSEVGRKENIRRIGEVAKLMMEVGLIVMTAFISPFRADREAVRNRMPYGDFLEIYCQVSLEACEARDVKGLYKKARAGQIKNYTGIDSAYEAPLKPELVVNTECLTLEESVSAVLRMLHERGMVVQ
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: HIS6_BIFA0
Sequence: MSLAVRVIPCLDVDDGRVVKGVHFENLRDAGDPVELAAEYYRQGADELTFLDVTASSSHRQTMVNVVTRTAEQIFIPLTVGGGVRTPEDVDSLLRCGADKVSVNTAAINDPTLISRVAERFGNQVLVLSVDARRERGEQHTQSGFEVTTMGGRKSTGIDALWWARRAEELGAGEVLLNSMDADGTQQGFDLEMIRAMREVVSIPIIASGGAGKAQDFPPAIAAGADAVLAASIFHYGKVTIGEVKDELRRAGYAVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRD_YERP3
Sequence: MADSKEIKRVLLSPLFDNNPIALQILGVCSALAVTTKLETALVMTLAVTLVTAFSSFFISLIRNHIPNSVRIIVQMVIIASLVIVVDQVLRAYAYEISKQLSVFVGLIITNCIVMGRAEAYAMKSPPIESFMDGIGNGLGYGVILVLVGFVRELVGSGKLFGVTVLETVQNGGWYLPNGLFLLAPSAFFIIGLLIWGLRTLKPAQIEKE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ITLN_ONCMY
Sequence: MKYCVLLIMIHLLLVELPQFPEALQGNVYAAAPVVAATDLRLRIRSSYIGRSCKEIRDRYNQHEDGLYYLSTASGTVYQTFCDMTTAGGGWTLVASVHENNVYGKCTMGDRWSSQQGSNPNWPDGDGNWANRATFGTAEGATSDDFKNPGYYDIVAEDISVWHVPNNSPMEHWNLGAILRYHTERSFLSIQGGNLHQLFKLYPVRYNAEASGNTGPVIPIVYDFGDKETTRELYGPNTRNQFEPGFITFRPINNELAAMAICSGVKPTTGGDTEHYCIGGGGHFPEGAPRQCGDFPAFDWNGYGTNTEWSASKQLTEAAVLLFYR
What is the function of this protein?
May be involved in innate immune surveillance.  May specifically recognize carbohydrate chains of pathogens and bacterial components in a calcium-dependent manner.  In vitro binds N-acetylglucosamine residues.
What are the official names of this protein?
Intelectin, RTInt.
Protein: HSPBB_DANRE
Sequence: MLCPSTFQPHLSPFMDFHWPVRSLWPETRPLFFQFEQEMMRHMQEMRHNMEFMERLHQRIFDEIDHVSPMTTFKPISFQLGKEGSHYALTLDTQDFSPEELAVKQVGRKLRVSGKTEKKQDDGKGSYSYRCQEFRQEFDLPEDVNPESVSCSLNNGQLQIQAPREGNTVSNERVIPITYTPAVKNPALQNSEPENQAVEAEAAEN
What are the official names of this protein?
Heat shock protein beta-11.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: COXX_THEPD
Sequence: MAPSAKDLLELFKVKQTALLLVTGVCAYLEGAGKPDPATLVLASLSMFLSIAGTTGFNMVLDADIDSAMFRTRNRPLPARRMSAKDAVLASSAALAAGLAAGVAVNPYVFVAGLLGFLIDIAVYTVLLKRKSPWSVVFGGFAGGMPALGGWAAATGGFGYQGVLLMLLVAVWSSLHIWTLSTYYSEDYRRAGVPMLPAVYGERAGVVASLAAAVAVFLVAFLAFRAGLISAVGFAVAAVPLVLAVAVLLKGLVSGEYREKAYRAFKLVNIFMGLFFVLLVLT
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ROA1_SCHAM
Sequence: MVNMDRENDHGEPEHVRKLFIGGLDYRTTDESLKQHFEQWGEIVDVVVMKDPKTKRSRGFGFITYSRAHMVDDAQNARPHKVDGRVVEPKRAVPRTEIGRPEAGATVKKLFVGGIKEEMEENDLRDYFKQYGTVVSAAIVVDKETRKKRGFAFVEFDDYDPVDKICLSRNHQIRGKHIDVKKALPKGDAPGGRGGGGRGGVGGGAGGGWGGGRGDWGGSAGGGGGGGWGGADPWENGRGGGGDRWGGGGGGMGGGDRWGGGGGMGGGDRYGGGGGRSGGWSNDGYNSGPQSDGFGGGYKQSYGGGAVRGSSGYGGSRSAPYSDRGSRGGGGGGYGSGGGRRY
What is the function of this protein?
This protein is a component of ribonucleosomes.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBFA_KOSOT
Sequence: MSAGYRKAMLESEIQKVLTEALRNFKGESEIDPTLVSIVRIELSKDKRYANIFVSYLGNDEEKKKAVEFMEENKGYFRTAVAKNIRLFKAPELRFHEDIGIEASLRISKILEEIKKQEQEKEENE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_XYLFA
Sequence: MTVTVSQVLRPRGPQIERLTENRAKVVLEPLGRGYAHTLGNALRRVLLSSIPGFAITEVEIDGVLHEYTTVEGLQEDVLEVLLNLKDVAIRIHSGDTATLSLFKQGAGVVTAADIKTDHNVEIINDGHVICHLTKDTTINMRLKIERGFGYQPAVVRRRPDDENRTIGRLILDASFSPVRRVAYVVEAARVEQRTDLDKLIIDIETNGTIDAEEALRTAADILTDQLSVFGDFTHRDRGTVKPASSGVDPVLLRPIDDLELTVRSANCLKAESIYYIGDLIQKTEVELLKTPNLGKKSLTEIKEVLGQRGLGLGVKLENWPPPGVSQYGMLG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: HEM1_CLAM3
Sequence: MLICLTASHHNASFEVLEKLSVAAPSVAGALMEQNDFIAGAVVLATCNRFEAYLDVEEPLTAARALAVEATVDVVSGASGIARDDVRGSVDVKCGDAVAEHLFAVSSGLESVVVGEGEIAGQVRRALEGARTGGTTSTGLERLFQTASNTSRGVKTRTGLQSAGRSMVRLALDLAESRIADWSATRVLLVGTGAYAGASLAALRDRGVVDVHVYSPSGRAQKFAGPHGIPAVEGRDLLRALAASDMVVTCSTAPTAVLAAHHMQGAAAVSGDGRRRLVIDLGLPRNVDPDVVTVDGVELLDLETISLHAPLRDLTATDDAREIVSTAAAEFRAASAEDEVAPAVVALRTHIFDVLEGELERVRKRGDSSDATEKALRHLVSVLVHQPSVRARELARQGEGARVVDAVQALFGLDVEMPAAVSSPVAVALSRTAEAGQAS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RRAS_RAT
Sequence: MSSGAASGTGRGRPRGGGPGPRDPPPGETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICTVDGIPARLDILDTAGQEEFGAMREQYMRAGNGFLLVFAINDRQSFIEVSKLFTQILRVKDRDDFPIVLVGNKADLETQRQVLRSEASSFSASHHMTYFEASAKLRLNVDEAFEQLVRTVRKYQEQELPPSPPSAPRKKDGRCPCVLL
What is the function of this protein?
Regulates the organization of the actin cytoskeleton.  With OSPBL3, modulates integrin beta-1 (ITGB1) activity.
What are the official names of this protein?
Ras-related protein R-Ras, p23.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C- terminal cysteine.
Protein: MAP21_BLAGS
Sequence: MAAQVTPELANLNSKPEGGAPPKQVPVKDVPENEDVESDDDNEGDQGAGEPGSTGAAKKKKKKKPKKKKKGGPKVQTEPPRVILSSIFPNNDYPVGELVEYKDDNAYRTTNEEKRYLDRMNNDFLSEYRYAAEVHRQVRQYAQKTIKPGQTLTEIAEGIEDSVRALTGHDGLTEGDNLLGGIAFPTGVNLNHCAAHYSPNAGNKMVLQYEDVMKVDFGVHINGRIVDSAFTVAFDPVYDNLLAAVKDATNTGIREAGIDVRMSDIGAAIQETMESYEVEIKGTTYPVKPIRNLNGHTIGQFEIHGGKNGKSVPIVKGGDQSKMEEGEVYAIETFGSTGRGYVRDDMETSHYAKVPDAPNVPLRLSSAKNLLNVITKNFGTLPFCRRYLDRLGQDKYLLGLNNLVANGIVDAYPPLCDIKGSYTAQFEHTILLRPNIKEVISRGYDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-1, MAP 2-1, MetAP 2-1, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDP2_HUMAN
Sequence: MSSTVSYWILNSTRNSIATLQGGRRLYSRYVSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGETTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIYQFTPPHYYTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLAQRPANLGLMQSLLLQRKASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLARMYRDDITVTVVYFNSESIGAYYKGG
What is the function of this protein?
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
What are the official names of this protein?
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial, PDP 2, Pyruvate dehydrogenase phosphatase catalytic subunit 2, PDPC 2.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: M2K1A_PHYPA
Sequence: MRRARGKFKGGNSALRVNVPKENAISDYVTASGTFQDGDIMLNKEGIRVVSQTQTSTPAANGNISLSDLETVKVLGKGSGGVVQLVRHKWTNETYALKVIHMNIEETTRKQIVQELKINHASQCPYVVICYHAFYNNGLISIVLEYMDGGSLADIMKELEPKCIKEPNLGVVCKQVLLGLMYLHQTRHIIHRDIKPSNLLVNHKGEVKISDFGVSAVLANSMAVRDTFVGTCTYMSPERVLGGTYGFDSDIWSLGLTLLECALGKYPYQPPGSEEGWMNFYELLQTIVDQPPPVAPADQFSPEFCSFISACLQKDPKCRPTAAELLNHPFVNKYDEEEYGLAKLLPPLVPLA
What is the function of this protein?
The CERK1, MEKK1a/b, MKK1a/b/c and MPK4a/b proteins are involved in pathogen defense.  The pathway induces rapid growth inhibition, cell wall depositions and accumulation of defense-related transcripts.  This protein is required for full defense response to fungal pathogen chitin.
What are the official names of this protein?
Mitogen-activated protein kinase kinase 1a, MAP kinase kinase 1a, PpMKK1a.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Protein: ZN461_HUMAN
Sequence: MAHELVMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSLGLSVSKPAVISSLEQGKEPWMVVREETGRWCPGTWKTWGFHNNFLDNNEATDINADLASRDEPQKLSPKRDIYETELSQWVNMEEFKSHSPERSIFSAIWEGNCHFEQHQGQEEGYFRQLMINHENMPIFSQHTLLTQEFYDREKISECKKCRKIFSYHLFFSHHKRTHSKELSECKECTEIVNTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLKHLRIHNGEKRYECNECGKAFNYGSELTLHQRIHTGEKPYECKECGKAFRQRSQLTQHQRLHTGEKPYECKQCGKAFIRGFQLTEHLRLHTGEKPYECKECGKTFRHRSHLTIHQRIHTGEKPYECRECGKAFSYHSSFSHHQKIHSGKKPYECHECGKAFCDGLQLTLHQRIHTGEKPYECKECGKTFRQCSHLKRHQRIHTGEKPHECMICGKAFRLHSHLIQHQRIHTGEKPYECKECGKAFSYHSSFSHHQRIHSGKKPYQCGKAFNHRLQLNLHQTLHTGEKPVRFPLLPPHPSLAS
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 461, Gonadotropin-inducible ovary transcription repressor 1, GIOT-1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS19_PROMP
Sequence: MGRSLKKGPFIADSLLKKVEKQNTDNDKSVIKTWSRSSTILPVMIGHTIAVHNGKAHIPVFITEQMIGHKLGEFAPTRTYRGHLRDKKGAR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: RS3_STRPQ
Sequence: MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFINKELADASVSTIEIERAVNKVIVSLHTAKPGMVIGKGGANVDALRGQLNKLTGKQVHINIIEIKQPDLDAHLVGENIARQLEQRVAFRRAQKQAIQRTMRAGAKGIKTQVSGRLNGADIARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: TMT1B_HUMAN
Sequence: MDILVPLLQLLVLLLTLPLHLMALLGCWQPLCKSYFPYLMAVLTPKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMGKAVK
What is the function of this protein?
Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine to hydrogen sulfide and other thiol compounds including dithiothreitol, 7alpha-thiospironolactone, L-penicillamine, and captopril.
What are the official names of this protein?
Thiol S-methyltransferase TMT1B, Methyltransferase-like protein 7B, Thiol S-methyltransferase METTL7B.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.