PharMolix/UniProtQA huggingface dataset:
Protein: GAR1_SCHPO
Sequence: MSFRGGRGGGFRGGRGGSRPFTPSGPPDQVIELGLFMHDCEGEMVCQSTNVKIPYFNAPIYLENKSQIGKIDEVFGPMNQVYFTVKPSEGIVSSSFKVGDKVYLSGDKLIPLDRFLPKPKTVGPKKPKGARNGPAGRGGRGGFRGGRGGSRGGFGGNSRGGFGGGSRGGFGGGSRGGSRGGFRGGSRGGFRGRF
What is the function of this protein?
Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.  The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs.  The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
What are the official names of this protein?
H/ACA ribonucleoprotein complex subunit gar1, snoRNP protein GAR1.
What is the protein family that this protein belongs to?
Belongs to the GAR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NHAB_YERPB
Sequence: MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGMTSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSVGFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFFIRMLPVTLPVFIFGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQASAKRTKQEKMKLIVQAIIGVWLVLALALHLAEVGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLLSSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMALPYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HCY4_HOMAM
Sequence: GAYGQGQNIGQLFVNILIFLFY
What is the function of this protein?
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
What are the official names of this protein?
Hemocyanin subunit 4.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: DNAJ_MACCJ
Sequence: MAKRDYYEVLGLSKGASKEEIKRAYKKLSKKYHPDINKEADAEDKFKEIAEAYEVLSDDQKKAQYDQFGHAGMGQGAGFGGQDFGGFGGFEDIFSSFFGGGARRDPNAPRQGNDLQYQMNVTFEEAVFGAEKEISVKKEVECDTCDGSGAQPGTNIKTCSTCGGRGNVHVEQNTPFGRVRSERTCPDCGGTGKEFEEKCSDCGGTGRKVKTVKISVKVPAGVDTGQQIRLSGQGEPGINGGPAGDLYVVFNVQDHAYFDRSGEDIFYTLELSIAQAALGDEVEVPTLEGKVKLTIPAGTQTGKRFRLKEKGVQNVHGYGRGDEYVTVKVMTPVKMTNRQAELLREFAEIDGHDITEQPSNFFDKTKRFFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAP_BRUAB
Sequence: MPNIDLPTLEAFVHAIPQNYKGPGGAVAVVRNGEIVLRHAWGFADLAARKAMTPETRMPICSVSKQFTCAVLLDCIGEPEMLDSALAAYLDQFEDGRPAVRDLCNNQSGLRDYWALTVLCGAAPEGIFLPDQAQNLLRRLKTTHFAPGTHYSYCNGNFRILADLIEQHTGRSLADLLAERIFAPAAMKTAELIPDTALFNECTGYEGDTVRGFLPAINRIHWLGDAGICASLDDMIAWEQFIDRTRHDENGLYRRLSSPQTFADGAPAPYGFGLKFEETGGKRLTGHGGALRGWRCQRWHCADERISTIVMFNFEGNASDAALKMMNAALGIPPAKPVRAQANPGWFGSWLNPETGLVLSLEDAGGGRMKARFGTGPEIMDISGENEAQSSMTTLRRDGDMIHLARKDENLHLAMHRLKGEARQDIAGRYRSDELEADLLLVSEGGAIYGAFEGFLGKSDMYPLYAAGPDVWLLPVQRSMDAPSPGEWKLVFHRDAAGRITGVTVGCWLARGVEYKRL
What is the function of this protein?
Hydrolyzes N-terminal residues in D-amino acid-containing peptides.
What are the official names of this protein?
D-aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S12 family.
Protein: PGTB2_CANAX
Sequence: MSNLPPDEKVILFDKSKHVQYIVEQESHRSFEYWLSEHLRMNGLYWGVTALITMNELSALAQQDVIDYIMLCWDDKTGAFGSFPKHDGHILSTLSALQVLKIYDQELTVLNDNNESSNGNKRERLIKFITGLQLPDGSFQGDKYGEVDTRFVYTAVSSLSLLNALTDSIADTASAFIMQCFNFDGGFGLIPGSESHAAQVFTCVGALAIMNKLDLLDVENKKVKLIDWLTERQVLPSGGFNGRPEKLPDVCYSWWVLSSLSILKRKNWVDLKILENFILTCQDLENGGFSDRPGNQTDVYHTCFAIAGLSLIDYKKYGFKEIDPVYCMPVEVTSKFVRRSA
What is the function of this protein?
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified.  Acts on YPT1 and SEC4 (By similarity).
What are the official names of this protein?
Geranylgeranyl transferase type-2 subunit beta, Geranylgeranyl transferase type II subunit beta, GGTase-II-beta, Type II protein geranyl-geranyltransferase subunit beta, PGGT, YPT1/SEC4 proteins geranylgeranyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit beta family.
Protein: SYM_MAGMM
Sequence: MRRILVTSALPYANGHIHLGHLVEYIQTDIWVRFHKLRGEECIYMCADDTHGTPIMLRAQKEGITPEQLVNQMHKEHAQDFAAFFVQFDEYYTTNSEENRLLSEEIYLKNRDGGHIEVDTIQQAYCEHDAMFLPDRFIRGTCPHCGAVDQYGDSCEVCSATYRPTELKEAKCAVCGSQPVEKSSEHYFFKLQDFSDYLKEWIQSGTLQPEMAAKLNEWFEQGLKHWDISRDGPYFGFEIPDAPGKYFYVWLDAPTGYMATTWHHCKKQGINFDDYWRRDDKAEVYHFIGKDILYFHTLFWPAMLHGSGFRTPTAVFAHGFLTVNGQKMSKSRGTFINARQYSAFLNPEYLRYYYAAKLTSRVDDLDLNLDDFVQRVNSDLVGKVVNLASRTAGFIVKRFEGQLCADYPEDDGLFQQFHQAGEEIAALYEKREFAKAMQAIMRLADSANQYVENHAPWVLAKDPLQSQRLQQVCSVTLNLFRTLMIFLKPVLPYMSNQVEQLFNAPQPFVWQDTAAPLQGVTINAFKHLMSRVEKEKVDAMVEAAREEAPSPTPQPKQQTKEKEEKNKKSADKDALAASIDFDTFMQVDLRVARIADAHEVEGADKLLQLTLDLGETLGTRTVFAGIKSSYSAEQLKGRLTVVVANLAPRKMKFGISEGMVLAAGPGGTDIHILSPDSGAQPGQRIK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLU2B_SCHPO
Sequence: MKFSQWYTLTAPLLISSLYTVNAANDLRGVASDKSDLYKPDAKGNWKCLGSDKLISFNQVNDDYCDCPDGSDEPGTSACHNGKFFCKNTGYISSYIPSNRVDDTVCDCCDGSDESLIKCPNTCAQKAREYLATLEEHNRLVKNGLKIREQWALESAKKTDEVKARYKEISDSLVAVSAEKTQLSEKVEKMKRSTDLGAEAVLPLDFQDLRVALLSLVDERNEMQERLDILTNLLDELTLLYETDKFDETMKEAILSFEDLKEQEIRRKVSSDDVHNYLESCNNHLSMLTGPSEDITFSSLIKDIKKILNSLVWNIKLSLINFGILSPSASSTPLTDSESYRRFEAAQRDLDAAEENEKSLEKEHTKLMHELEYHHGWDLYRAIKGMETKREIGGYTYKVVFYENVFQDSILLGNFASQEGNVLKYENGQSCWNGPHRSAIVTVECGVENEIVSVLEAQKCEYLIKMKSPAACSPDQLKQSLLNTQNSANENAVNGMEDKESSVDEL
What is the function of this protein?
Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER).  Specifically required for the cleavage of the final glucose.  The subunit beta retains the catalytic subunit alpha in the ER.
What are the official names of this protein?
Glucosidase 2 subunit beta, Alpha-glucosidase 2 subunit beta.
Protein: PURA2_CUPPJ
Sequence: MDTATKTGYADVLVGLQYGDEGKARVVDHLAAGYDVIARFNGGANAGHTIATSEGILRLRQVPSGVLHPRVSLYIGSGCVIGLRQLASEIEMLAGQGIDLAGRLTISDRCPVVQPAHFLSDRRDGGRIGTTGNGIGPCYADLAARMRGGERSAFQLCDLMRDESRVFEQMMRLAAQRDDEDIAVLIQEMRQAWQVVRPFVTDNPVALLERVEGGARVLFEGAQSVMLDVVQGAQPWVTSSHTLPSYAYVGGDLPCRYHRKTIGVAKAMVSRVGSGPLPTELGAERSEAYCADAGREGRGRADEAARFDPRALLAQGDAFSTGIAIRMLSNEYGTGTGRPRRVGLLDVAQLQLAIRQFGVDEVYLNKCDSLAVFAQTRDRCIPVVVGSRDGNAMHVMRFPAFDESVIPRDDATPLPPQLETLLEWLADVLGRPLRGIGLGPQRAQMRLFKTQP
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase 2, AMPSase 2, AdSS 2, IMP--aspartate ligase 2.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARL6_BOVIN
Sequence: MGLLDRLSGLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQDIVPTIGFSIQKFKSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDKLRMVVAKEELRTLLNHPDIKHRRIPILFFANKMDLRDALTSVKVSQLLCLEDIKDKPWHICASDAIKGEGLQEGVDWLQDQIQSVKT
What is the function of this protein?
Involved in membrane protein trafficking at the base of the ciliary organelle.  Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia.  Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade.  Isoform 2 may be required for proper retinal function and organization (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 6.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so- called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane (By similarity).
Protein: RL24_STRPI
Sequence: MGVRKIKEKPNVCKKGDKVRVIAGKDKGTEAVVLTALPKVNKVIVEGVNIVKKHQRPTNELPQGGIVEKEAAIHVSNVQVLDKNGVAGRVGYKFVDGKKVRYNKKSGEVLD
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: AROQ_GLAP5
Sequence: MKKILLLNGPNLNMLGKREPHIYGSQTLADIENHLQQLAKARGYCLEYFQANGEEPIINRIHQSFQNTDFIIINPGASTHTSVALRDALLSVAIPFVEVHLSNVHAREPFRHHSYLSDVAKGVICGLGAKGYDYALDYAIQFLKSGK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: FABPL_TAKRU
Sequence: MSFSGKYQQVSQENFEPFMKAIGLPDEVIQQVKELKSTSEIEQNGNDFKITITTGPKVTVNKFTIGKETEMDTITGEKIKTVFHLDGNKLKVSLKGIESVTELADPNTITMTLGDVVYKTTSKRM
What are the official names of this protein?
Fatty acid-binding protein, liver-type, Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, L-FABP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y875_CHLPN
Sequence: MKRVIYKTIFCGLTLLTSLSSCSLDPKGYNLETKNSRDLNQESVILKENRETPSLVKRLSRRSRRLFARRDQTQKDTLQVQANFKTYAEKISEQDERDLSFVVSSAAEKSSISLALSQGEIKDALYRIREVHPLALIEALAENPALIEGMKKMQGRDWIWNLFLTQLSEVFSQAWSQGVISEEDIAAFASTLGLDSGTVASIVQGERWPELVDIVIT
What are the official names of this protein?
Probable lipoprotein CPn_0875/CP_0994/CPj0875/CpB0904.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0875/CT_734/TC_0107 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: Y2998_CORGL
Sequence: MSIGFDRDLYIKMQSQHINERREQIGGKLYLEMGGKLFDDMHASRVLPGFTPDNKIAMLTELKDELEILVAINAKDLERKKTRADLDISYEEDVLRLIDVFRELGFLAEHVVLTQLEDDNYQALAFKQRLERLGLKVAVHRVIPGYPTDARRIVSEEGFGINEYVETTRNLVVVTAPGPGSGKLATCLSQIYGDHQRGIKSGYAKFETFPIWNLPLEHPVNLAYEAATADLDDINIIDPFHLAAYDTKATSYNRDVEVFPLLKTMLEMLSGSSPYKSPTDMGVNMVGSAIIDDAACQEAARQEIVRRYFKALVDERREEQDDTISARIAIVMSKAGCTVEDRRVVARALDVEESTGAPGCAIELNDGRLVTGKTSELLGCSAAMVLNALKELAGIDRSVDLLSPESIEPIQSLKTQHLGSRNPRLHTDEVLIALSVSAANSETARRALDELKNLRGCDVHTTTILGSVDEGIFRNLGVLVTSEPKYQRKALYRKR
What are the official names of this protein?
UPF0371 protein Cgl2998/cg3325.
What is the protein family that this protein belongs to?
Belongs to the UPF0371 family.
Protein: AP4S1_BOVIN
Sequence: MIKFFLMVNKQGQTRLSKYYEHVEINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDDYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSDS
What is the function of this protein?
Component of the adaptor protein complex 4 (AP-4).  Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection.  They control the vesicular transport of proteins in different trafficking pathways.  AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.  It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons.  AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
What are the official names of this protein?
AP-4 complex subunit sigma-1, AP-4 adaptor complex subunit sigma-1, Adaptor-related protein complex 4 subunit sigma-1, Sigma-1 subunit of AP-4, Sigma-4-adaptin, Sigma4-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Protein: TAL_SYNP6
Sequence: MAANLLEQLRGMTVVVADTGGIQSIATFTPRDATTNPSLITAAAQMPQYQSIIDDTLRQVRTELGAEAPVEAIVAEAIDELFVAFGLRILEIVPGRVSTEVDARLSYDTEATIAKARKLIGLYERAGIRRDRVLIKIASTWEGIRAAEVLEKEGIHCNLTLLFGFHQAVACAEAGVTLISPFVGRILDWYKKESGRDAFPGAEDPGVQSVTQIYNYYKKFGYATEVMGASFRNISEIIELAGCDLLTISPGLLEELRQTEALLERKLDPAIAESLELEQIHLDRDRFAELHQADRMANEKLDEGIRGFCKAIDTLEGLLKQRLAVLEGKAVFHHAAHEVFSVCDLDGDGFITREEWLGSDAVFDALDLNKDGKLNEEDLLAGLGATLQMAGRAVATV
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASP1_TRIPD
Sequence: MEKSESSTIQIAESSKDRKGKAPLLPPPVHHERAAGYKRGVAIFDLILRISAATAALAATIVMGTTEQTLPFFTQFFQFRASYDDLPTFTFFVIAMAIVTGYLILSVPFSIVCIARPVVAAPRILLILCDTLTVTLATSAAGASAAIVYLAHNGXSDANWLAICQQFNDFCQRVSGAVVAAFVSAVLLIFLVVLSAIVLKKH
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 1, TpCASP1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: GPMA_RHILW
Sequence: MSGTLVLVRHGQSDWNLKNLFTGWKDPDLTALGIEEANAGGKALAEYGIKFDIAYTSVLVRAQHTLKLILDKVGQPDLPTIRDQALNERDYGDLSGLNKDDARAKWGEEQVHIWRRSYDVPPPGGESLRDTGARVWPYYLTEILPRVLRGEKVLVAAHGNSLRSLVMVLDKLTKEGVLALNLATGVPMVYKLKADSTVASKEVLGDMSGAH
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: ADDG_RAT
Sequence: MSSDTSQAVITTPPPPSMPHKERYFDRINESDPEYLRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHDPTGLLALQQIADYIMANSFTGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLADLFGWAHLANTYISVRVSKEQDHIIIIPRGLSFSEATASALVKVNIIGEVVDQGSTNLKIDHSGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGDVAYYDYQGSLDEEEERIELQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQMACEIQVQAVAGAGGVDNLLILDLQKYKAFTHGVAMTGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLVREKPRHKSDVEIPATVTAFSFEDDSVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDPSKVSSGTPIKIEDPNQFVPLNTNPTEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMRFEDDDQGPPAPPNPFSHLMEGELEEYTKTIERKQQGLDDAEQESLSDDAASVSQIQSQTQSPQSVPERLEENHELFSKSFTSVDVPVIVNGKDEMHDVEDELAQRVSRLTTSTTIENIEITIKSPDRTEEVLSPDGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA
What is the function of this protein?
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network.  Plays a role in actin filament capping.  Binds to calmodulin (By similarity).  Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure (PubMed:27927653, PubMed:32830539, PubMed:32029431).  Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo (PubMed:27927653, PubMed:32029431).  Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension (PubMed:32830539, PubMed:33414130).  Involved in renal blood flow (RBF) autoregulation (PubMed:32830539, PubMed:32029431, PubMed:33414130).  Plays a role in podocyte structure and function.  Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization.  Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes.  Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli.  Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement (PubMed:33308016).  Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (PubMed:33414130).  Promotes the growth of neurites (By similarity).
What are the official names of this protein?
Gamma-adducin, Adducin-like protein 70, Protein kinase C-binding protein 35H.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. Adducin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NAPA_YERPA
Sequence: MKLSRRDFMKANAAVAAAAAAGMTIPTVAKAVGETTNAIKWDKAPCRFCGTGCGVLVGTQNGRIVASQGDPDSPVNRGLNCIKGYFLPKIMYGKDRLTQPLLRMKDGQYDKEGDFTPISWEKAFDIMELKFKNALKEKGPTAVGMFGSGQWTVWEGYAALKLLKGGFRSNNLDPNARHCMASSVVGFMRTFGMDEPMGCYDDIEEADAFVLWGSNMAEMHPVLWSRMTSRRLTNAHVRIAVLSTYEHRSFELADNPIVFTPQTDLVIMNYIANYIIQNNAVDKDFLAQHVNFRRGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFEDFKTFVAEYTLEKAAKMSGVPEDQLESLAQLYADPKVKLVSYWTMGFNQHTRGVWANNMCYNLHLLTGKISTPGSGPFSLTGQPSACGTAREVGTFSHRLPADMVVTNEKHRQIAETTWQLPAGTIPEKVGLHAVAQDRALKDGTLNAYWVMCNNNMQAGPNINEERMPGWRDPRNFIVVSDPYPTISALSADLILPTSMWVEKEGAYGNAERRTQFWRQQVPSPGEAKSDLWQIVEFAKRFNVEEVWPAELVNQKPEYRGKNLYEVLFANDVVSKYPLSEIPDDQLNDEARDFGFYIQKGLFEEYASFGRGHAHDLAPFDVYHQVRGLRWPVVDGKETLWRYREGFDPFVPKGEEVRFYGKPDGKAVIFALPYEPAAESPDQEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVLFIHPLDAKARGLHRGDKVKVISRRGEVISLVETRGRNRPPRGLVYMPFFDAAQLVNNLTLDATDPLSKETDFKKCAVKLERVVA
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: NIBA1_HUMAN
Sequence: MGGSASSQLDEGKCAYIRGKTEAAIKNFSPYYSRQYSVAFCNHVRTEVEQQRDLTSQFLKTKPPLAPGTILYEAELSQFSEDIKKWKERYVVVKNDYAVESYENKEAYQRGAAPKCRILPAGGKVLTSEDEYNLLSDRHFPDPLASSEKENTQPFVVLPKEFPVYLWQPFFRHGYFCFHEAADQKRFSALLSDCVRHLNHDYMKQMTFEAQAFLEAVQFFRQEKGHYGSWEMITGDEIQILSNLVMEELLPTLQTDLLPKMKGKKNDRKRTWLGLLEEAYTLVQHQVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNYLIGKIKAMVAQPAEKSCLESVQPFLASILEELMGPVSSGFSEVRVLFEKEVNEVSQNFQTTKDSVQLKEHLDRLMNLPLHSVKMEPCYTKVNLLHERLQDLKSRFRFPHIDLVVQRTQNYMQELMENAVFTFEQLLSPHLQGEASKTAVAIEKVKLRVLKQYDYDSSTIRKKIFQEALVQITLPTVQKALASTCKPELQKYEQFIFADHTNMIHVENVYEEILHQILLDETLKVIKEAAILKKHNLFEDNMALPSESVSSLTDLKPPTGSNQASPARRASAILPGVLGSETLSNEVFQESEEEKQPEVPSSLAKGESLSLPGPSPPPDGTEQVIISRVDDPVVNPVATEDTAGLPGTCSSELEFGGTLEDEEPAQEEPEPITASGSLKALRKLLTASVEVPVDSAPVMEEDTNGESHVPQENEEEEEKEPSQAAAIHPDNCEESEVSEREAQPPCPEAHGEELGGFPEVGSPASPPASGGLTEEPLGPMEGELPGEACTLTAHEGRGGKCTEEGDASQQEGCTLGSDPICLSESQVSEEQEEMGGQSSAAQATASVNAEEIKVARIHECQWVVEDAPNPDVLLSHKDDVKEGEGGQESFPELPSEE
What is the function of this protein?
Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1.  May be involved in the endoplasmic reticulum stress response (By similarity).
What are the official names of this protein?
Protein Niban 1, Cell growth-inhibiting gene 39 protein, Protein FAM129A.
What is the protein family that this protein belongs to?
Belongs to the Niban family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Lipid-anchor.
Protein: CI_DROYA
Sequence: FEGCFKAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVKTVHGAEFYANKKHKGLPLDDVNSRLQRDNSQGRHNLQEHNIDSSPCSEDSHIGKILGTSSPSIKSESDISSSNHQLVNGVRASDGLLTYSPDDLAENLHLDDGWNCDDDVDVADLPIVLRAMVNIGSGNASASAIGGAVLARQRFRSRLQTKGINSSTIMLCNIPESNRTIGISELNQRITELKMEPCTAGDIKIPMSTNTAIEVFPEDLLQNHTTFRNTVLNKQGISTVSGSVQGQFRRDSQNSTASTYYGSMQSRRSSQSSQVSSIPTMRPIPSCTTTAASFYDPISPGCSRRSSQMSNGVNCYAFTSTSGLPIINKDLNA
What is the function of this protein?
Involved in segment polarity.  Required for the normal development of the posterior half of each embryonic segment.  Engrailed protein directly represses ci expression in posterior compartment cells (By similarity).
What are the official names of this protein?
Protein cubitus interruptus.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.