PharMolix/UniProtQA huggingface dataset:
Protein: RPIA_STAAN
Sequence: MKDVKALKLMTLNDVLSQINGDMTLGIGTGSTMELLLPQMAQLIKERGYNITGVCTSNKIAFLAKELGIKICEINDVDHIDLAIDGADEVDPSLNIIKGGGGALFREKVIDEMASRFVVVVDETKIVQYLGETFKLPVEVDKFNWYHILRKIESYADIKVERRVNEDVAFITDNGNYILDCKLPKGIDPYKFHEYLIHLTGVFETGYFLDMADQVIVGTQEGVKILEK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RS14_DICNV
Sequence: MAKKCMVNREIKRIKTVKKFAAKREELKEIIRKVATYSDEERAAAQEKLQKLPRNASPSRVQRRCRITGRPHAVYRKFGLSRIKLRELTMRGEVPGVRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: NUOB_NITHX
Sequence: MSSPTTKFSNAASSAGGPRVTPAAASILDPRTGRPVGAGDPYFLEVNHELSDKGFFVAATDDLITWARTGSLMWMTFGLACCAVEMMQVSMPRYDVERFGFAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPIDVYVPGCPPTAEALLYGILLLQKKIRRTGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CHSA_PEA
Sequence: MVTVNEIRQAQRAEGPATVFAIGTATPQNCVEQSTYPDFYFRITNSQHKTELKEKFQRMCDKSMIKKRYMHLTEEILKENPSLCEYMAPSLDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPYVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIVGSDPLPDVEKPLFELVWTAQTIVPDSEGAIDGHLREAGLTFHLLKDVPSLVSKNIEKALVEAFQPLNISDYNSIFWIAHPGGPAILDQVEAKLGLKQRKMQATRHVLSEYGNMSSACVLFILDEMRRKSKEDGLATTGEGLEWGVLFGFGPGLTVETVLLHSMAT
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 1A, Naringenin-chalcone synthase 1A.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: COAD_BACMK
Sequence: MTSIAISSGSFDPITLGHLDIIKRGAKVFDEVYVVVLNNSSKKPFFSVEERLELIREATKDIPNVKVDSHSGLLVEYAKMRNANAILRGLRAVSDFEYEMQITSMNRKLDESIETFFIMTNNQYSFLSSSIVKEVARYGGSVVDLVPPIVERALKEKFKTPLK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNA1_CANAX
Sequence: MMLPQGYTFRKLKLTDYDNQYLETLKVLTTVGEISKEDFTELYNHWSSLPSIYHPYVITNASGIVVATGMLFVEKKLIHECGKVGHIEDISVAKSEQGKKLGYYLVTSLTKVAQENDCYKVILDCSPENVGFYEKCGYKDGGVEMVCRF
What are the official names of this protein?
Glucosamine 6-phosphate N-acetyltransferase, Phosphoglucosamine acetylase, Phosphoglucosamine transacetylase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. GNA1 subfamily.
Protein: 3MGH_BACCN
Sequence: MKAPPPFYEGDTLDVAKKLLGQKLVHIVDGVKRSGYIVEVEAYKGPDDKAAHSYGGRRTERTEIMFGAPGHAYVYLIYGMYHCFNVITAPVGIPQGVLIRALEPAEGVKEMKLARYGKMELTKTQYKNLTNGPGKLCRALNITLEERGLSLQGDKLYIELVPESQHLSSQYEIVKGPRINIDYAEEAVHYPWRFYFQNNPFISK
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: H12_BOVIN
Sequence: MSETAPAAPAAAPPAEKTPVKKKAAKKPAGARRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAATGEAKPKAKKAGAAKPKKAAGAAKKTKKATGAATPKKTAKKTPKKAKKPAAAAVTKKVAKSPKKAKAAKPKKAAKSAAKAVKPKAAKPKVAKPKKAAPKKK
What is the function of this protein?
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber.  Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers.  Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
What are the official names of this protein?
Histone H1.2, CTL-1.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Mainly localizes in euchromatin.
Protein: RS2_MICLC
Sequence: MPVVTMRQLLDSGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLQQSLSYIDRAYEFVKETVAHGGTILFVGTKKQAQEAIAEQAGRVGMPYVNHRWLGGMLTNFSTVSKRVQRMKELEEIDFEDVAGSQFTKKELLLLNRELEKLQANLGGIRNMAKTPSAVWVVDTKKEHLAVDEAQKLGIPVVAILDTNCDPDEVAYPIPGNDDAIRSVNLLTRVVADAVAEGLIARQGGKSGQAAAEPMAEWERELLEQHNAQQAEQAEAPAAEAPAEPAEAPAAEAAPQGE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: NUSB_CYAP4
Sequence: MQPRRIARELALLALSQLPQKPERLTTQDLQSVVVAAVRTLAGEAQDALETAAMELKRGRDRLLASEIQAVDVQSSRAMVTEAITLAETAVNRLGMVLDLPEFVQLANQQQVRDFSLDILKQVLTHRTAIDHLLETALVDWQFNRLAQIDRNILRIAVAEILYLKTPTQVTINEAVELAKRYSDEDGYRFVNGVLRRTIPHLEAQAQGT
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: APOE_ZALCA
Sequence: MKVLWAALVVALLAGCWADVEPESPLEENLEPELEPKRELEQEVEPEAGWQAGQPWELALARFWDYLRWVQTLSDQVQEEVLSNQVTQELTTLMEETMKEIKAYRAELEEQLGPMASETQARVAKELQAAQARLRSDMEDVRTRLSQYRGEVQAMLGQSTEELRARFASHMRKLRKRVLRDAEDLQKRLAVYRAGVREGAERSVSTIRERLWPLLEQARTRHAKVDALATQPLRERVNALGQQLRGRLEEVGSRARSHLDEVREQMEEVQAKMEEQANQMRQQAEAFQARLKGWFEPLVEDMQRQWAVLVEKVQAAVGTSPTTPPVETK
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: RBL_FLERU
Sequence: SVGFKAGVKEYKLTYYTPEYETKETDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEEDQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYTKXFQGPXHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAFYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIXMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGERDTTLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVRSGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAAEGNEIIREASKWSPELAAACEVWKEIRFNFKAVDTLDPS
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYY_STRPS
Sequence: MHIFDELKERGLIFQTTDEEALRKALEEGQVSYYTGYDPTADSLHLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVKSIQGQLSRFLDFENGENKAVMVNNYDWFGSISFIDFLRDIGKYFTVNYMMSKESVKKRIETGISYTEFAYQIMQGYDFFVLNQDHNVTLQIGGSDQWGNMTAGTELLRRKADKTGHVITVPLITDATGKKFGKSEGNAVWLNPEKTSPYEMYQFWMNVMDADAIRFLKIFTFLSLDEIEDIRKQFEAAPHERLAQKVLAREVVTLVHGEEAYKEALNITEQLFAGNIKNLSVKELKQGLRGVPNYQVQADENNNIVELLVSSGIVNSKRQAREDVQNGAIYVNGDRIQDLDYVLSDADKLENELTVIRRGKKKYFVLTY
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_STAAE
Sequence: MDNDRQKALDTVIKNMEKSFGKGAVMKLGDNIGRRVSTTSTGSVTLDNALGVGGYPKGRIIEIYGPESSGKTTVALHAIAEVQSNGGVAAFIDAEHALDPEYAQALGVDIDNLYLSQPDHGEQGLEIAEAFVRSGAVDIVVVDSVAALTPKAEIEGEMGDTHVGLQARLMSQALRKLSGAISKSNTTAIFINQIREKVGVMFGNPETTPGGRALKFYSSVRLEVRRAEQLKQGQEIVGNRTKIKVVKNKVAPPFRVAEVDIMYGQGISKEGELIDLGVENDIVDKSGAWYSYNGERMGQGKENVKMYLKENPQIKEEIDRKLREKLGISDGDVEETEDAPKSLFDEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAMT_MYCTU
Sequence: MTTGRLSMAEILEIFTATGQHPLKFTAYDGSTAGQDDATLGLDLRTPRGATYLATAPGELGLARAYVSGDLQAHGVHPGDPYELLKTLTERVDFKRPSARVLANVVRSIGVEHILPIAPPPQEARPRWRRMANGLLHSKTRDAEAIHHHYDVSNNFYEWVLGPSMTYTCAVFPNAEASLEQAQENKYRLIFEKLRLEPGDRLLDVGCGWGGMVRYAARRGVRVIGATLSAEQAKWGQKAVEDEGLSDLAQVRHSDYRDVAETGFDAVSSIGLTEHIGVKNYPFYFGFLKSKLRTGGLLLNHCITRHDNRSTSFAGGFTDRYVFPDGELTGSGRITTEIQQVGLEVLHEENFRHHYAMTLRDWCGNLVEHWDDAVAEVGLPTAKVWGLYMAASRVAFERNNLQLHHVLATKVDPRGDDSLPLRPWWQP
What is the function of this protein?
May be a S-adenosylmethionine-dependent methyltransferase involved in fatty acid metabolism.
What are the official names of this protein?
Probable fatty acid methyltransferase Rv3720, S-adenosylmethionine-dependent methyltransferase Rv3720, AdoMet-MT, SAM-MT.
What is the protein family that this protein belongs to?
Belongs to the CFA/CMAS family.
Protein: YIKA_SCHPO
Sequence: MSMRIWSRSSSAYSAIARSSSWFNNSLFSSCLLRFYSNPPKKTKKNTLISLRKSAETANEKFIEKINKEHQLFKPGQIVVDLGCAPGIWSTIAARHVGLFGRVIACDIIPCRLPENSSMIQGNILSMEIQLEIAKAAIRSRNSFFRNQQDHNSASIPYLQSVFEEERDTKEKAKIEDLSADVIMSDLGPPFPMVQGFEFWISKLPYLAMQTNEHLAVKDELDSLYLAQAALLFAIKALKPDGIFLCKVLESSHLRSFAEDLSMCFKCVKKIQFKTKIKDELYAVYFCSGKQLSCHSKLLNI
What are the official names of this protein?
Putative ribosomal RNA methyltransferase PB17E12.10c, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Protein: GPI11_MAGO7
Sequence: MPLVDPVTMSTPSTPAKAMGKSLPNTVKDPSPPPKAGSHTRSPVESPSNSYYIAASIPALQLQIFVLLWKRLVDDPVATMSRLILPVMALIQVFYAVVLLPVAGSGKQWRKPRPGEKKKAQGGEPNIALATLLSLLLTLIATPPIHALMVLFGAPFLTHAPHTFLCALNLSLLTLFPLFYTRGAEASAWRALAGFTAPIDESVGGLVGACFGAWLGAVPIPLDWDRDWQRWPVTVLTGIYVGYAIGSYGGRTLLRIRGYSAKRS
What is the function of this protein?
Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
What are the official names of this protein?
Glycosylphosphatidylinositol anchor biosynthesis protein 11.
What is the protein family that this protein belongs to?
Belongs to the PIGF family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: IF23A_XENLA
Sequence: MNKLYIGNLSENVSPTDLESLFKESKIPFTGQFLVKSGYAFVDCPDETWAMKAIDTLSGKVELHGKVIEVEHSVPKRQRSRKLQIRNIPPHLQWEVLDSLLAQYGTVENCEQVNTESETAVVNVTYANKEHARQGLEKLNGYQLENYSLKVTYIPDEMATPQAPSQQLQQQPQQQHPQGRRGFGQRGPARQGSPGAAARPKPQTEVPLRMLVPTQFVGAIIGKEGATIRNITKQTQSKIDIHRKENAGAAEKPITIHSTPEGCSAACKIIMEIMQKEAQDTKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGSIEPCAKAEEEIMKKIRESYENDIAAMNLQAHLIPGLNLNALGLFPSSSSGMPPPSVGVPSPTSSTSYPPFGQQPESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPAEGPDAKLRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLETHIKVPSYAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDEVVVKITGHFYASQLAQRKIQEILAQVRRQQQQQQKTVQSGQPQPRRK
What is the function of this protein?
RNA-binding protein that acts as a regulator of mRNA transport and localization.  Binds to the RNA sequence motif 5'-UUCAC-3'.  Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity).  Mediates the specific association of Vg1 RNA to microtubules.  Binds specifically to the vegetal localization elements (VLE or VgLE) in the 3'-UTR of Vg1 and VegT mRNAs.  Binds to the Vg1 and VegT mRNAs in both the nucleus and the cytoplasm.  May regulate mRNA translation (By similarity).  Acts as a transcription regulator (By similarity).  Binds to the 5'-[TA]GGTTACT-3' motif within element 3 of the TFIIIA gene promoter (By similarity).
What are the official names of this protein?
Insulin-like growth factor 2 mRNA-binding protein 3-A, IGF2 mRNA-binding protein 3-A, IMP-3-A, 69 kDa RNA-binding protein A, IGF-II mRNA-binding protein 3-A, KH domain-containing transcription factor B3-A, RNA-binding protein Vera-A, Trans-acting factor B3-A, VICKZ family member 3-A, VLE-binding protein A, Vg1 RNA-binding protein A, Vg1 RBP-A, Vg1 localization element binding protein A, VgLE-binding and ER association protein A.
What is the protein family that this protein belongs to?
Belongs to the RRM IMP/VICKZ family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Accumulates along the vegetal cortex in oocytes as oogenesis progresses ('late pathway' for RNA localization). Colocalizes with Vg1 RNA along the vegetal cortex.
Protein: PYRC_ECO45
Sequence: MTAPSQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQYFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVKQ
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: MET_MICMU
Sequence: MKASAVLAPGILALLFTLVQGSDGECHEALAKSEMNVNMKYQLPNFTAETPIQNVVLHDHHIYLGATNYIYVLNDRDLQKVAEYKTGPVLEHPDCFPCQNCSDIANFSGGIWKDNINRALLVDTYYDDQLISCGSVNRGACQRHVLPPDNPADIRSEVHCMFSPQADEEPGQCPDCVVSALGAKVLLSVKDRFINFFVGNTLNSSYFPDHPLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGAQLAKQIGASLNDDILFGVFAQSKPDSAEPMNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPHHEHCFNRTLLRNSSGCEVRKDEYRTEFTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGSSTPHVNFQLDSHPVSPEVIVEHPLNQNGYTLVVTGKRITKIPLNGLGCGHFQSCSQCLSAPSFVQCGWCHDKCVRSEECPTGTWTQEICLPAIHKVFPTSAPLEGGTMLTICGWDFGFRRNNKFDLKKTKVLLGNESCTLTLSESTTNMLKCTVGPAMSEHFNMSIVISHGRGMTQYSTFSYVDPVITSISPSYGPKAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQIISTEFPVKLKIDLANRETSSFSYQEDPVVYEIHPTKSFVSGGSTITGVGKNLNSVSVPRMVINVQEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHSHSEAVLCTVPNDLLKLNSELNIEWKQAVSSTVLGKVIVQPDQNFTGLIVGVVSISIILLLLLGLFLWMKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSQDNINGEVDT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DXS_GLUOX
Sequence: MSKKTSTIPTYGRYPELDRVRFPADMRNLSVDQLKQLADELRSETVDAVSTTGGHLGASLGVVELTVALHAVFNTPDDRIIWDVGHQAYPHKILTGRRDRIRTLRQPEGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAVAHHLRAEEDPSYHERNVIAVIGDGSISAGMAYEAMNNAAVAGPGANRLIVVLNDNEMSIAPPVGSMSDYLSRLMSSRQFFSLRDLAGKVAKRLPGKIERTAKRAEEYARGMITGGTLFEELGFYYVGPVNGHDMSQLVPILRNLRDADDQGPILLHIITEKGRGYKPAEAAGDKYHAVSKFNVVTGEQKKAPAGPPSYTSIFSRELMRRAKTDDKLITITAAMPSGTGLNAFAKAYPDRFFDVGIAEQHAVTFAAGIASEGLRPFCAIYSTFLQRAYDQVVHDVALQNLPVRFAIDRAGLVGADGATHAGAFDLNYLCCLPNMVVMAPSDEVELLHATATACEYDAGPIAFRYPRGNGIGLDLPEKGEVLEIGKGRIVREARRAPNARGGVAILSLGPRMHESLRAADQLAAQGVPVTVADARFAKPIDKALVEDLARQHEVFITIEEGAIGGFSSLVVQHLAETGLLDKVKFRPMALPDRYIDHNTQDAQYEDAGLTAPHIVRTAADALGVEVAQQSA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: GRCA_VIBC1
Sequence: MIQGIQITKAANDELLNSIWLLDSEKNEARCVAAASTYEADQVIAISDLGDYESREVAIETAPRIEGGQHLNVNVLKRETLEDAVAHPENYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: SYGA_SALSV
Sequence: MQKFDTRTFQGLILTLQDYWARQGCTIVQPLDMEVGAGTSHPMTCLRALGPEPMATAYVQPSRRPTDGRYGENPNRLQHYYQFQVVIKPSPENIQELYLGSLKELGMDPTIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEYADVDFLFTCFEQYEKEAQQLLALENPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCNKDK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_CHLTB
Sequence: MTTESLETLVEQLSGLTVLELSQLKKLLEEKWDVTAAAPVVAVAGAAAAGDAPASAEPTEFAVILEDVPSDKKIGVLKVVREVTGLALKEAKEMTEGLPKTVKEKTSKSDAEDTVKKLQEAGAKAVAKGL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RL10_THEON
Sequence: MAHVAEWKKKEVEELTNIIKSYPVIALVDVANVPAYPLSKMREKLRGKALLRVSRNTLIELAIKRAAQELGKPELEKLIDHIQGGAGILATEMNPFKLYKLLEESKTPAPAKPGVPVPRDVVIPAGPTSISPGPLVGEMQALGIPARIEKGKVSIQKDYTVLKAGEVITEQLARILNALGIEPLEVGLNLLAAYEDGIVYTPEVLAIDEEEYINLLQQAYMHAFNLSVNTAYPTSQTIEAIIQKAYLGAKNVAVEAGYITPETVEDIFGRALRAVLLIAQNLPEELLDEKTKELLNQQAQIAVATQPQQEEKVEEAEEEEEEEEASEEDALAGLGALFG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10, Acidic ribosomal protein P0 homolog.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.