PharMolix/UniProtQA huggingface dataset:
Protein: MEP3_ARTOT
Sequence: MHGLLLAGLLALPMNVLAHPAEQQTSSVLSRRGVDIDSFRLPLKAKYMDSDATAQKIQALSFSKEDDYVSTATKLVKSTFPKSTFRVVDDHYIGTNGIGHVHFKQTAHGLDIDNSDFNVNIDRDGKVFSFGNSFFTGEIPKESPMVKREFSDPVKALKGAVKALNLPVKSENAKAKTVEGKESFEFQGTSGALSAPKAKLVYLQKEDGSLALTWKVETDVGDNWLLSYVDAHDSETVHNVVDYVASAEFKVFAWGLNDPTEGNPTSFRDPWTASSPFTWHSDGTNKYPTTRGNNAIAQDNPTGGSTYLNNYRPQSANLIFNYPWTAAMTPPSSYKDFSITQLFYTTNRYHDLLYSFGFNEAAGNFQVNNNNKGGKGNDFAIVNAQDGSGTNNANFATPPDGSPGRMRMYNWTTARPNRDGCLEAGIVIHEYTHGLSNRLCGGPANSACLNALESGGMGEGWGDFYATAIRLKPRDTKNTNYSMGAWAANDPKGIRAYLYSTNLQTNPYMYTSVNNLREVHGIGTVWATMLYELMWGLIEAHGGTYSADPVFRNGVPQDGRHLAMKIVMDGMALQPCNPNFVQARDAIIDADRALTNGANKCTIWKAFAKRGLGYGAKYDPRTRTGSNQLPPGC
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 3, Fungalysin MEP3.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURR_SHIFL
Sequence: MLYLTKIRNAESEFTGNEQKIADFLRARVSELKSVSSRQMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATALHVHSSITSDDSLEVIARKLNREKEMALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLADSPLRRLAHFTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQHQ
What is the function of this protein?
Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc).  Binds to two adjacent inverted repeats within the operator region.  MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
What are the official names of this protein?
HTH-type transcriptional regulator MurR, MurPQ operon repressor.
Protein: NUDC_ACTSZ
Sequence: MNAIQIQDCGFWLIHVNQDIYFPDNNLPFGTAESLNLTHRNAARIGEWEGYPLFVVKEDPAEQREWTALRSLLRLPEEKFYLLNRGVELNYFLKTHRRCGKCGHQTEMARDEWAVQCQNDACGYRTYPVICPSIIVAVRRGKEILLANHTRHMPKNGGSGMYTTLAGFVEIGESFEQTVEREVFEETGLKVKNIRYFGSQPWAFPNSQMVGFLADYDSGEIRLQEDELNDARWFHCDQPLPELPPEGTIALKLINATLNICRQA
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.  The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing.  Has preference for mRNAs with a 5'-end purine.  Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
What are the official names of this protein?
NAD-capped RNA hydrolase NudC, DeNADding enzyme NudC, NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
Protein: CRCB1_PROMP
Sequence: MNKKYLLTFLLTAYCATFLRFYFKNNFVISIIGSFLYGFFISRKISKSKKEILFSGFFACFTSFSGFVHFLYQFIIQGYYLKLFIYLNVIVILNLIIMYIGFQLSRKIT
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1297_NEIG1
Sequence: MSIQSGEILETVKMVADQNFDVRTITIGIDLHDCISTDIDVLNQNIYNKITTVGKDLVATAKHLSAKYGVPIVNQRISVTPIAQIAAATKADSYVSVAQTLDKAAKAIGVSFIGGFSALVQKGMSPSDEVLIRSVPEAMKTTDIVCSSINIGSTRAGINMDAVKLAGETIKRTAEITPEGFGCAKIVVFCNAVEDNPFMAGAFHGSGEADAVINVGVSGPGVVKAALENSDAVSLTEVAEVVKKTAFKITRVGELIGREASKMLNIPFGILDLSLAPTPAVGDSVARILEEMGLSVCGTHGTTAALALLNDAVKKGGMMASSAVGGLSGAFIPVSEDEGMIAAAEAGVLTLDKLEAMTAVCSVGLDMIAVPGDTPAHTISGIIADEAAIGMINSKTTAVRIIPVTGKTVGDSVEFGGLLGYAPVMPAKEGSCEVFVNRGGRIPAPVQSMKN
What are the official names of this protein?
UPF0210 protein NGO1297.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: RNY_LACP7
Sequence: MLIKIVIACVITAIIVALIAWKSAISYYKKVVEGKIGSADEKAREIIDEALKTAETKKREALLEAKEESLKTKNELERETKERRAELQRYEKRVLTKEETLDRKTEALEKKEAKLVAKEQELDRLRVEVEESHQKQVAELEKISGLTSEQAKEYLIKTVEDEVKHETAVLIKELESRAKEEAEKKAKDYVVTAIQKCAADHVAETTISVVQLPNDEMKGRIIGREGRNIRTLETLTGVDLIIDDTPEAVILSGFDPIRRETARIALEKLIVDGRIHPARIEEMVEKAQKEVETMIREEGEAATLEVGVHGIHPELVRLLGKMKFRTSYGQNALKHSIEVAILSGLLAGEIGVDVRIAKRAGLLHDIGKSVDHEMEGTHVQIGVDLCRKYKESPIVINAVEAHHGDVEFQSLIACIVQAADTISAARPGARRETLETYTNRLKQLEDITNGFKGVDKSFAIQAGREVRVMVVPDQVTDDDMVLLARDLSKKIESELEYPGMIKVNVIRESRVTDYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: OR7C2_HUMAN
Sequence: MERGNQTEVGNFLLLGFAEDSDMQLLLHGLFLSMYLVTIIGNLLIILTISSDSHLHTPMYFFLSNLSFADICFTSTTVPKMLVNIQTQSKMITFAGCLTQIFFFIAFGCLDNLLLTMTAYDRFVAICYPLHYTVIMNPRLCGLLVLGSWCISVMGSLLETLTILRLSFCTNMEIPHFFCDPSEVLKLACSDTFINNIVMYFVTIVLGVFPLCGILFSYSQIFSSVLRVSARGQHKAFSTCGSHLSVVSLFYGTGLGVYLSSAVTPPSRTSLAASVMYTMVTPMLNPFIYSLRNKDMKGSLGRLLLRATSLKEGTIAKLS
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 7C2, Olfactory receptor 19-18, OR19-18, Olfactory receptor 7C3, Olfactory receptor OR19-22.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COBS_SHEWM
Sequence: MHVLRQQLTLFFIAMGFFTRIPMPTWVKVDGESLNKANRYFGLIGLLVGGICALVYEITRGFLPVSVSIIFAMIAGLVVTGGFHEDGLADTADGLGGGWSVADKLKIMKDSRIGTYGALALVMGLMLKFILLSELALYNPDLVVTALIVGHTLSRVMAASLIFSQSYVRDDDSSKSKPLAQNQTVNELLILLATAVLVLWCSGLSGGLYIAIGLVLLRWGLIYLFHRQIGGYTGDTLGATQQLAELACYLMLLGFSL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPIA_PECCP
Sequence: MTQDELKKAVGWAALDYVRPDTIVGVGTGSTAAHFIDALGSIKHQIKGAVSSSDASTEKLKSLGIPVFDANEVDSLDVYVDGADEINGHMQMIKGGGAALTREKIISALSRQFICIVDASKQVDVLGKFPLPVEVIPMARSYVARELVKLGGQPVYRQGVVTDNGNVILDVHNLNIMDAIAVENHINGIPGVVTVGLFANRGADVALVGTSEGVKTVVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: CL160_CAEEL
Sequence: MDLKSWILLSCTLLPLSVTSYECYVTPCTRDIIIVVDGSSSMQTSTYVSQEINMITKLTYSWTLDDAKVRLALVGAYLGNEFNGLDYFTDSSLIEKRLQSFRLAAMQYGLFSGDFNTTVRFLDERYVGPRATFGPRANVQKRIIIFSAHKGASDIASTKSKLQEFAQLGYAVTIVGIGVSEDVYKGTFYHKFVSVQWFELGVVAQSIIDTITEDGICFLDQGWTTPKQEICTTSTTTTRAPTTTTTVTTVKGVTGKPATTAKPVPPTHPPFPVGDYQDCSCTTQSLYIDIIFVIDVSEGMGQGGLMMVKAEINTLVGQMSLDPNIQKHVQVGLIKYSDKAEVVFKPSDYTNEDEFTEDLWSDPRLEDVDEKSDEVNLHLGLQQAAKMTASMRNGVRKVIVVYAASYNDEGNDDARQIAANIRETGYAIITVAFVEPESSNLVMKIGEIASPRMNFTSFRDDLLVEQMEDALCQVNCYCPNGWKQLVLENRKYGECFFPTKIDASWTASKFECPVLSKEHTGNGHLVYVNSELKNTFLNQFYMDNWYPENQENPNYDIGYYYDQATKKFIWVNGVTNNPYSNWATGHPDVKQGDCVMAKLLKDSKNDFRWNSVSCTSEYGRGLCQEAACDTDFYCAPSSN
What are the official names of this protein?
C-type lectin domain-containing protein 160.
What are the subcellular locations of this protein?
Secreted.
Protein: GLNH_BACSU
Sequence: MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKDNDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRIPMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKVLAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKNYQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE
What is the function of this protein?
Part of the ABC transporter complex GlnHMPQ involved in glutamine transport.
What are the official names of this protein?
ABC transporter glutamine-binding protein GlnH.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RNH2_ACTP7
Sequence: MSTNFIYPNAHLIAGVDEVGRGPLVGAVVTAAVILDPNNPIEGLADSKKLSEKKRLLLAEEIKAKALCWSLGRAEPEEIDRLNILHATMLAMQRAVAGLNIQPDFVLVDGNRIPTLPMPAQAVIKGDSLVAEISAASILAKVARDQEMAELDVQYPEYGFAKHKGYPTKLHFEKLEQFGATPFHRKSFAPVKKILGL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19S_ASCSU
Sequence: MVKQPSVKDVDQHEIVRYIAGFLKKSGKVKVPEWSDLVKLGITKELAPVDSDWYYVRTASVARRLYIRSPTGVGALRRVYGGNKRRGVTPNHFARASGSVIRKALQTLEAIKWVEKHPDGNGRILTKQGRKDLDRIASQMRQNTKITLEP
What are the official names of this protein?
40S ribosomal protein S19S.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS19 family.
Protein: SYGB_THEMA
Sequence: MRTALLEVGLEELPASEFHSILKQLEEKSAELLKAYRVSSGSVEVFVGSRRFGVILKNLPERQEDFTEEKKGPPLNVAYDENGKPTRALEGFLRNNNASLENVVHREGYVYLSRVVEGKPVEEVLPDLFRDLVLGLNFRKPMRWGSGEHEYIRPVHWIVAMVDGRVLDLEIFGLRSSRISYGKRYHAGSIEIPDSERYYESLKKGFVISSHLERKKFVLEQIDEFEKRSSMKIERDEELIEEIVAITEYPRIVVGQFDRKYLELPEEIIVTAVKHHQRSFIAHKGTLTNTFVAFQDGPQPPENVVKGYERVINARLEDARYYFQKDLETPLEKMNEKLKEIVFQEKLGTLYDKVERIKKISQRLCEDLKLPGSFTQKVLEAASICKADIASKVVYEFPELQGVMGRIYALREGINEEIATAIEDHYSEEPQTVIGSILGIADRIDTIVGNFAIGNVPTSSKDPYGLKSKADTIFRIIRKNEWDISLEELLTFASSLVGYRLSEELETFFAGRFYQFLINELGISFDVARAVNHLWKKPLRGILSAEALQEISEKPEFQDLFVGFERVHNITKNHDSTKFDGALFEKEEEKKLMNKFYEVKEKVLKALERLNYREALQYLIELKPYIDEYFDNVFVMVKRDDLRVNRLSFLKNIDELFMMVGDMTYLVKRSQV
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_ROSS1
Sequence: MLSDLDIAQAARLRPIHAVAADLGLTDDDIERYGRNIAKIDLAVLQRLTDHPRGRYIVVTAITPTPLGEGKTTTTIGLGQALARLGKRSVVTIRQPSMGPTFGIKGGAAGGGYSQVVPMEPFNLHLTGDIHAVGAAHNLLAAMIDNHLHHGNRLDIDPYTVSWTRVVDISDRALRQVIVGLGGKENGPVRQAQFDITVASEVMAILALTTGLHDLRQRLGRIVVAQTRDGAPVTADDLKAAGAMTVLLKEAIKPNLLQTLEGSPALVHCGPFANIAHGASSVLADLIGLHCADYVVTESGFGADIGFEKFCDIKCRASGLAPDAVVLVATVRALKAHSGRYAITAGKPLDPQLSEENPDDVAAGVANLTAQVRIAKLFGRPVVVAINRFPDDFPSEIEVVRQVARDAGAFEVVESFVFAEGGAGGYDLAQAVMAACEMPGKFTPLYPLDMSLRDKIETLATKVYGAARVEYTPEASRQLTRFEQQGYGALPICMAKTQLSISHDPKLRGAPSGYVFPIREVRLAAGAGFIYPLAGDIRTMPGLPAHPAAERIDIDADGRTVGLS
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: ACPS_CUTAK
Sequence: MIIGIGVDVCDISRWEAAVQRHPGMVRKMLTHTEAVMPARSQAARFAAKEALYKALGGGEGLSWQDCEVVTDGEAVRFELRGSLARRAEELGVRRVHLSLTHDAGVAVAMVVCEG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y582_METMA
Sequence: MKILLFICGEGLGHTGRCLALGKEFLAAGHEVNFGAYGYSKGLVQKTGYSAYEIPSEIKLAGEAGTFDIRKSIKETLNNLSPSGFRKILRLIEKLDPDVVLSDGYYTGILAAQKRKVPVYFIGHQFNMEEFFWKKGLFAGIAGIFVKRFYNYVFSSVDGIIVPDYPLPYSVNRKNFTISRAVNDNIFFSGPLIRCRYQEAGEKAFKRPNVLSTIGAFGYRAAVFRNVLEAAKLDPSIYYTFISGPEIDPEQFSKVPENVEFTGFTENPFPYYKGSDLVITAGGHGTIMESLAFGLPILSFPDEKHAEQENNASVLEEAGYGKRMSYLTPPEVILACIREIFEDENYSKKTRRLMELAEVLDGPAAVRKFLEEKHRG
What are the official names of this protein?
Uncharacterized glycosyltransferase MM_0582.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
Protein: TEG7_EHV4
Sequence: MFKWLMSSLCGTKNPASLEEVYEPIMGGKNPATMLRLQSALAAVNALLPATLTIEDVISSADNTRRLVKAQTLARTYQACQHNIECLSRHRASSDNPNLNAVVATHMANAKRLSDTCLAALMHLYLSVGAVDATTDTMVDHAIRMTAENSVVMADVAVLEKTLGLEPQPSVMAHDLLALESSVYNSGNSVPVNDYPAEDVESTQSVHSPLLSKRPSNTEVVCSSIPVKSNLKSKPRRKPSLVAA
What is the function of this protein?
Plays several roles during the time course of infection, including egress of virus particles from the perinuclear space and secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.
What are the official names of this protein?
Tegument protein UL51 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL51 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host Golgi apparatus.
Protein: PXPA_PSEF5
Sequence: MSRLLLNCDIGESFGNWTLGLDAEVMPFIDCANIACGFHAGDPGIMRKTVALALANGVRIGAHPAYQDLAGFGRRSMSYSPEEIQDLLHYQVGALDGICRAQGGRVEYVKPHGAMYNDMMAKPAQLRAVIQAVAAYDPQLPLMLMATRDNSAAQALGDEYGVTLWFEAFADRAYDNAGHLVSRQLPGAVHHDAQTILQQALTIARGEPLAASDGSALLLHANTLCVHGDNASSVAAVQRIREALNQQSGL
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: CSN2_NEUCR
Sequence: MSDDDFMQDSDQEYDFEYEDDEEEDTGDVDIENKYYNAKQTKTSDPEEALQEFLSIPPLEQEKGDWGFKALKQAIKLEFKLKRYQEATEHYEELLTYVKSAVTRNYSEKSIDNMLNYIEKGYDDPKAVQCIEKFYSLTLQCFQSTNNERLWLKTNIKLARLLLDRKDYHAVARKLRELHNACRKSDGTDDPSKGTYSLEIYALEIQMYSETRNNNQLKVLYQKALKVRSAVPHPKIQGVIRECGGKMHMSEENWKEAQSDFFEAFRNYDEAGDLRRIQVLKYLLLTTMLMKSDINPFDSQEMKPYRNDPRIFAMTELVDAYQRDDIYRYEDVLQKNTDLLADPFIAENIDEVTRNMRTKGVVKLIAPYTRMRISWLAERLRITEPEVMDILSFLIVDGRVKGRIDEHKGVLELESREDADHVQAITVLSEAVGNLFNAVFKSTDGFQPGQGDFMNSMADQSADIGSLDDTMRSMGSGKRGRRVGLTQRAY
What is the function of this protein?
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity).  The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex.
What are the official names of this protein?
COP9 signalosome complex subunit 2, Signalosome subunit 2.
What is the protein family that this protein belongs to?
Belongs to the CSN2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AASD1_HUMAN
Sequence: MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSGFQVVLEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPGSQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEVEQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLSDLQVIKILGTEKGKKNRTNLIFLSGNRVLKWMERSHGTEKALTALLKCGAEDHVEAVKKLQNSTKILQKNNLNLLRDLAVHIAHSLRNSPDWGGVVILHRKEGDSEFMNIIANEIGSEETLLFLTVGDEKGGGLFLLAGPPASVETLGPRVAEVLEGKGAGKKGRFQGKATKMSRRMEAQALLQDYISTQSAKE
What is the function of this protein?
Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).
What are the official names of this protein?
Alanyl-tRNA editing protein Aarsd1, Alanyl-tRNA synthetase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
Protein: KHSE_CORK4
Sequence: MPHDIPVGRSVTVRVPASSANLGPGFDTLGLAVGLYDIVTVEVTASGLTVDVQGEGAGEVPLDGTHLVVRAIREGLRVAHADVPGLAVSCENAIPQSRGLGSSAAAAAAGVCAANALADNALTTDQVIQVVSSFEGHPDNAAASVLGGAVVSWTDTPVDGETAPQYHAIGVDVHPDIRATAFIPDFTASTNAVRRVLPSDVSHVDARFNVSRTAVMTVALRTNPELLWEGTRDRLHQPYRADALSVSAEWVNRLRNRGYAAYLSGAGPTIMVLSTEDLPAEIVDTASSEGLRVITLPIAGPIQVNRKELG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_UREU1
Sequence: MEEKYLILSIESSCDETSLALFENNKLIAHKISSSASAQAFHGGVVPELASRYHEHNINRLFVDILNETKIDPLTITHVAYTAMPGLPGCLHVGKVFAKQLASLINAELVPINHLHAHVFSASIDQELVFPFLGLVVSGGESCLYLVSDYDQIKILNQTQDDAIGECYDKVARILGWNYPGGPIIDKNYQEDLATLEFIKSQPAAKNFSFSGLKTAVINYVHNSKQKKLDFDPIVIASSFQKFAINEVIKKVKYYLDLYQLKRLAIGGGVSANSLLRKKIRDLNVISYIPQMIYTGDNAAMIGAYAYALIKNHKKSILIK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_ANADF
Sequence: MTTANVEQKVKNIIADQLGVGEDEIKITSSFIEDLGADSLDIVELVMAMEEEFEVEIPDEEAENIKTVQDAVNYITTHKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTM1_CANGA
Sequence: MELANICNATIAKGIAVQKDSYGGYGVYIVDPGALVGCNDPKLGGDKIELLRVSSVFNVKNLMEAMNALEGEYAEDGQRAADMFKSIIGSSIEELSAVSETCLLVYFMMVIYLMGEQGYAVPMKISRYIDTVLLGTTVNNASNCIESMLIHYEHVALFHELDNNLQKLHKTLISKMPSKKNYSIELLRQIYSATVSRVLEIPQELHEENYMDNYVVTPSLVPILDYVNHGDKTSRNAYYDVDRRKGDIILYLDLTVVNPGKLKPNTEVLITYKDIEDSLAMITKYGFDPANYTTTGTKIFSCTFDKMYLSTNKFDNEIDIRNFYQWFSINPSLQFVLNSENEWLINDSLAEFERLLVPFATSSQRNEHYWIYSDGDDARKRFMEYFDIDEVEDEDEAWAQLETQFKWFESSENDLMPFPPCVWTVKSKFLKEKEATGYELEKVIQNKLENSRALYNETTNQFQAYLENYLDYRIDVLQEYSPEDTENENAVSQLIARELSVLLKIRDRINNNKSIFLNSEDKKYAKLPLLPTKNVERPPWLSEGDDDFDQD
What is the function of this protein?
Methyltransferase which mediates trimethylation of cytochrome c (CYC1).
What are the official names of this protein?
Cytochrome c lysine N-methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: FKBP5_CHLAE
Sequence: MTTDEGAKNSGESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFNSSHDRNEPFVFSLGKSQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSVPKIPSNATLFFEIELLDFKGEDLLEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGERMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMRAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSSAVEEEKAEGHV
What is the function of this protein?
Immunophilin protein with PPIase and co-chaperone activities.  Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90).  Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.  Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1.  Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP5, PPIase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, FKBP-51, FK506-binding protein 5, FKBP-5, Rotamase.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TGT_HELPS
Sequence: MDFQLQATDNNARAGLLNLAHSQVATPVFMPVGTQGCIKSLDATDMQGILGAKLILANTYHLYLRPGEKVVEELGGLHRFAQFHGSFLTDSGGFQAFSLSDNVKLQEDGIVFKSHIDGSKHLFTPAKVLDIQYSLNSDIMMVLDDLVGLPAPLKRLEESIKRSAKWANLSLEYHKQKNRPNNNLFAIIQGGTHLKMRSLSVGLTHEGFDGYAIGGLAVGESADEMLETIAHTAPLLPKDKPRYLMGVGTPENILDAIGLGVDMFDCVMPTRNARNATLFTHSGKISIKNAPYKLDDTPIEENCACYTCKRYSKAYLHHLFRAKELTYARLASLHNLHFYLELVKNARNAILEKRFLSFKKEFLKKYHSRSH
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: UL97_MUHVS
Sequence: MSVELTPPRSDGSVGFAPVVVPPAPRKPLRRRAVSDLEKLYKVKRRLVFGADDGAVDNDTSNNNSGSSSTTSRSRRKTAADVVSDSPKRTDDSSTAGEDGYTHCVHSCACTPGERHLLCCELVSIGDSVSVARCPLCSLGISTTYLSRGCCRGRSKVTGGDEDEEDEDEEENSQDEDRDEEEAASASSSGGLEWSDDSNSALSWSDENIIISPFPGLKCYVTTFEDIRQPVLLETGSAYLPVYVPYDESFCRNRCLERGGDDDDERDATLIGKGSFGQVWRLSDKKTALKAAASESINETLLTVWISGVVRSRAQDAGYRGELDDSVYCNILVATGSCLRHNLVSFASFDRDLYNYRGWHYAGLASYRRAFSGIADALRFLNLRCGVGHFDVTPMNVLINYDRADDRQIARAVICDFSLSQCHTEGTTGHCVVVFQQTKTVRALPKSAYYLTDIYHPAFKPLMLQKLCAIEPRKQFPKPSANRFCVSDLCALGHVAAFCLVRVLDERGQLKVRSTSEDALFGVARKTCDALARHSVDEVANFCSLLITRQLAYTATLLGSDDMREPMARLCDYFETVSDKDAPDRFRSVYKRARREIDGSYMVRLLLAASETEDGRYLLDNIRATCLMVDSEDLDVDPYKIFP
What is the function of this protein?
Serine/threonine protein kinase that plays important roles in several processes including viral morphogenesis, nuclear viral egress, viral replication or regulation of host cell cycle progression (PubMed:17910700, PubMed:32973148).  Participates in the acquisition of tegument during virion morphogenesis in the nucleus (By similarity).  Phosphorylates host SAMHD1 and thereby counteracts its antiviral effect by reducing its dNTP hydrolase activity (PubMed:31548683).  Inhibits host DNA synthesis by cyclin A/CDKN2A sequestration to the cytoplasm (PubMed:32973148).
What are the official names of this protein?
Serine/threonine protein kinase M97.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. HCMV ganciclovir subfamily.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host cytoplasm. Note=Present in host nucleus at early times but redistributes to a predominantly cytoplasmic localization pattern at 24 hours post infection.