PharMolix/UniProtQA huggingface dataset:
Protein: ST1E1_BOVIN
Sequence: MSSSKPSFSDYFGKLGGIPMYKKFIEQFHNVEEFEARPDDLVIVTYPKSGTTWLSEIICMIYNNGDVEKCKEDVIFNRVPYLECSTEHVMKGVKQLNEMASPRIVKSHLPVKLLPVSFWEKNCKIIYLSRNAKDVVVSYYFLILMVTAIPDPDSFQDFVEKFMDGEVPYGSWFEHTKSWWEKSKNPQVLFLFYEDMKENIRKEVMKLLEFLGRKASDELVDKIIKHTSFQEMKNNPSTNYTTLPDEVMNQKVSPFMRKGDVGDWKNHFTVALNEKFDMHYEQQMKGSTLKFRTKI
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:1900200) (By similarity).  Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation.  Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency.  Does not sulfonate cortisol, testosterone and dopamine (By similarity).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
What are the official names of this protein?
Sulfotransferase 1E1, ST1E1, Estrogen sulfotransferase, Sulfotransferase, estrogen-preferring.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RL25_THENN
Sequence: MVSLEVRLRTPKGKREAKRLRRRGEVPAVVYGPATDPIPVKIKRSLLEKVFHTITETTPIRLVIKDDEERTVSEKTVFLKMIQRDKVSEAIVHVDFYEPVKGHRMRINVPLKVVGKPVGVEKGGFLEVYHEEIPVETDPDRVPQEIEVDVSSLDLGDVIHARDLKLPEGVKCLLEDEEAVVSILVPKEVSIEEEEVEEEVAEPEVIKRKEEEEEE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: DGCQ_ECOUT
Sequence: MGVVRVQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLAKQAGRNRVCASDNA
What is the function of this protein?
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity).  Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria.  Involved in the regulation of cellulose production (By similarity).
What are the official names of this protein?
Probable diguanylate cyclase DgcQ, DGC, Cellulose synthesis regulatory protein.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BLAP_BACSU
Sequence: MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADRSGIVKEVKKKEGDFVNEGDVLLELSNSTQ
What are the official names of this protein?
Biotin/lipoyl attachment protein, BLAP.
Protein: GLYC_GTOVV
Sequence: MGQLISFFQDIPIFFEEALNVALAVVTLLAIIKGIVNVWKSGILQLFVFLVLAGRSCSFKVGHHTNFESFTVKLGGVFHELPSLCRVNNSYSLIRLSHNSNQALSVEYVDVHPVLCSSSPTILDNYTQCIKGSPEFDWILGWTIKGLGHDFLRDPRICCEPKKTTNAEFTFQLNLTDSPETHHYRSKIEVGIRHLFGNYITNDSYSKMSVVMRNTTWEGQCSNSHVNTLRFLVKNAGYLVGRKPLAFFSWSLSDPKGNDMPGGYCLERWMLVAGDLKCFGNTAVAKCNLNHDSEFCDMLRLFDFNKNAIEKLNNQTKTAVNMLTHSINSLISDNLLMRNKLKEILKVPYCNYTRFWYINHTKSGEHSLPRCWLVSNGSYLNESDFRNEWILESDHLIAEMLSKEYQDRQGKTPLTLVDLCFWSAIFFTTSLFLHLVGFPTHRHIQGDPCPLPHRLDRNGACRCGRFQKLGKQVTWKRKH
What is the function of this protein?
Stable signal peptide (SSP): cleaved and functions as a signal peptide.  In addition, it is also retained as the third component of the GP complex.  The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: MDH_RUEPO
Sequence: MARPKIALIGAGQIGGTLAHLVALKELGDVVLFDIAEGTPEGKALDIAESGPSEGFDAKLKGTQSYADIAGADVCIVTAGVPRKPGMSRDDLLGINLKVMKSVGEGIRDNAPDAFVICITNPLDAMVWALQQFSGLPANKVCGMAGVLDSARFRHFLAEEFNVSMKDVTAFVLGGHGDTMVPSVRYSTVAGIPLPDLIKMGWTSQEKLDAIVQRTRDGGAEIVGLLKTGSAYYAPATSAIEMAEAYLKDQKRVLPCAAYCNGELGVKGMYVGVPTVIGAGGIERIIDVSLTKEEQDMFDNSVNAVKGLVEACKGIDGSLA
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: DOEA_HALED
Sequence: MIQVSLPFTREEYAGRLWKVRTEMASRGIDVLVISDPSNMAWLTGYDGWSFYVHQCVLLGLEGEPVWYGRRMDANGALRTCWMDPDNITYYPDHYVQNPDMHPMDYLAQTILPDRGWHEGVVGMEMDNYYFSAKAYQCLLRELPHARFADANSLVNWCRAIKSPQEIEYMRVAGKIVAGMHSRILEVIEPGLPKSKLVSEIYRVGIEGWTSPEGKVFGGDYPAIVPMLPTGKDAAAPHLTWDDSPFREGEGTFFEIAGVYKRYHAPMSRTVYLGRPPSEFVRAESALLEGIENGLEVAKPGNRTADIAMALGAAMDKYGFDRGGARCGYPIGISYPPDWGERTMSLRPSDETILEPGMTFHFMPGLWVEDWGLEITESILITESGCETLADFPRQLFVK
What is the function of this protein?
Involved in the degradation of ectoine, which allows H. elongata to utilize ectoine as both a carbon and a nitrogen source for growth.  Catalyzes the hydrolysis of ectoine to N-acetyl-L-2,4-diaminobutyric acid (N-Ac-DABA).  It can produce both isoforms N-gamma-acetyl-L-2,4-diaminobutyric acid (N-gamma-Ac-DABA) and N-alpha-acetyl-L-2,4-diaminobutyric acid (-Nalpha-Ac-DABA), however N-alpha-Ac-DABA is the essential substrate for the subsequent catabolic enzyme DoeB.
What are the official names of this protein?
Ectoine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ELOH1_SCHPO
Sequence: MDLTGAHMLKIHRPSIDHPFGVDLWHLFEQLSIKTIGWNPSEFEYIPGKTPMSQWSSVIVSITAYYVIILSGRAIMTNRKPLKQRRLFQLHNFILTIISGALLALLVEEVFRNYMRNGLFYCVCDSRHFTQRLVTLYYLNYLTKYLELMDTVFLFLKKKPLAFLHCYHHGITALLCFTQLLGRTSVQWGVIGLNLYVHVIMYSYYFLAACGRRVWWKQWVTRVQIIQFVLDLILCYFGTYSHIAFRYFPWLPHVGDCSGSLFAAFFGCGVLSSYLFLFIGFYINTYIKRGAKKNQRKAAGKADNTSVAAAAGSEALAATTATNASPFSARSRKL
What is the function of this protein?
May be involved in the synthesis of very long chain fatty acids.
What are the official names of this protein?
Putative elongation of fatty acids protein 1, 3-keto acyl-CoA synthase SPAC1B2.03c, Very-long-chain 3-oxoacyl-CoA synthase 1.
What is the protein family that this protein belongs to?
Belongs to the ELO family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RBS_NICBE
Sequence: MASSVLSSAAVATRSNVAQANMVAPFTGLKSAASFPVSRKQNLDITSIASNGGRVQCMQVWPPINKKKYETLSYLPDLSVEQLLSEIEYLLKNGWVPCLEFETEHGFVYREHHKSPGYYDGRYWTMWKLPMFGCTDATQVLAEVEEAKKAYPQAWIRIIGFDNVRQVQCISFIAYKPEGY
What is the function of this protein?
(Microbial infection) Required for tobamovirus movement (e. g.  tobacco mosaic virus (TMV)).
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic, NbRbCS, RuBisCO small subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast. SUBCELLULAR LOCATION: Cell junction, plasmodesma. Note=(Microbial infection) May be present in virus replication complexes (VRCs) of tobamovirus infected cells.
Protein: YPIP_BACSU
Sequence: MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAERDLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCTLGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKNGDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVARKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP
What are the official names of this protein?
Uncharacterized protein YpiP.
Protein: Y1098_SINFN
Sequence: MDISRAEQRILHHLAQGGRIEIKREGKTIAEIRCFTRDGWVYPGVDLELFRKLKRKRAIRSSSGRPYRITERGLYLVRSELDNR
What are the official names of this protein?
UPF0386 protein NGR_c10980.
What is the protein family that this protein belongs to?
Belongs to the UPF0386 family.
Protein: RF1_BRUMB
Sequence: MIALPQDRMDQLLKRFSMIESQMANNPDSDTYVKLASEYSELQDVVGKIRELSDARMEASDLAAMRDDASTDAEMRALAVEELPEVEKRIAVLEQDVQILLLPKDAADDKNAILEIRAGTGGLEAALFAGDLFRMYERYAAEKGWRVELVSASEGDAGGYKEIIATVSGKGVFSKLKFESGVHRVQRVPETEAGGRIHTSAATVAVLPEAEDIDIEIRNEDIRIDTMRASGAGGQHVNTTDSAVRITHIPTGIMVVQAEKSQHQNRARAMQILRARLYDMERQKAESERSQARRSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDRVMEGELDELVDALISDHQTALLAELGEQP
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMDH2_HEVBR
Sequence: LESDFADMDVIGISGNFCSDKKPAAVNWIEGRGKSVVCEAIIKEEVVKKVLKTDVALLVELNMLKNLAGSAVAGALGGFNAHAGNIVSAIFIATGQDPAQNVESSHCITMMEAVNDGKDLHISVTLPSIEVGTVGGGTQLASQSACLNLLGVMGACKESPGSYSRLLATIVAGSVLAGELSLMSAIAAGQLVKSHMKYNRSSKDVSKAAS
What is the function of this protein?
Catalyzes the synthesis of mevalonate.  The specific precursor of all isoprenoid compounds present in plants.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2, HMG-CoA reductase 2.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Plastid membrane; Multi-pass membrane protein.
Protein: COBT_CORGB
Sequence: MVPAELFARVEFPDHKILAQTKDFHDSLTKPPGSLGKLEQIGCFISACQGQIPPRPLNNSKIVVFAGDHGVATKGVSAYPSSVSLQMAENITNGGAAINVIARTTGTSVRLIDTSLDHEAWGDERVSRSCGSIDVEDAMTQEQVERALEIGKRIADQEVDAGADILIPGDLGIGNTTTAAALVGTFTLAEPVVVVGRGTGIDDEAWKLKVSAIRDAMFRVRDLRQDPIAIARKISSPDLAAMAAFIAQAAVRRTPVLLDGVVVTAAALLANKLAPGARRWFIAGHRSTEPAHSVALDALALDPILEFGMYLGEGSGAATALPMVKIAVDLMNDMSTFSSAGVDGPLNASSEAPEQNTE
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: HPS6_RAT
Sequence: MKRAGTLRLLSDLSNFTGAARLRELLAGDPAILVRCSPDGRHLLLLRPPGSPAPQLLVAVRGPGLPLERAWSEGDPSPLDVFFVPWLARPALILVWESGLTEVWGVGMEPGWKLLQSTELCPDGGARVMAVAATRGRLVWCEERQPGVEDQPGQLSMAFNHCVCVKTLDTSGEAGTKLGCTHILLHHCPSFGLIASRKELFLVPTSTTWPGVAHVLLIWSPSKGKVIVAAPSLGLSHSKSLNPKQGDTWDFRTLLRGLPGFLSPREPLAVHTWAPSSQGLLLLDLKGKVSLVQCHGGTRTVGLLQEAPVGLQGSAALGTFHGTLACVLGSTLELLDMSSGRLLERKVLSTDRVHLLEPPAPGVKNEEDLETRGALRLLSALGLFCVCWEAPQGLEVPSDKDLVFEEACGYYQRRSLRGTQLTPEELRHNSMFRAPQALASILQGHLPPSALLTTLRAELRDYRSIEQLKAQLVAGDDEETGWTELAEHEVARLLRTHLTGDQLAQFNTIFQALPTAAWSATLQALQLQPDRSGRLRSQAPPDVWKKVLRAPTAGKEHPNGILPPFELLCQCLGQLEPQWLPPFVELAQQQGGPGWGAEGPSLPLYRRALSVLGEEGKRPEALELELLLGSGRPKAVLQAVRQLIKKEQWERALEAGLTLDSSSPLLRSEIFNLLLAEFAQHRRLDTHLPLLCRLCPPEVAPDELLLLLRTHLPDDAGATPFPEPGAEPGAEPPLTVGLVRALLEQTGAQGRSSGPVQSTFEDILWDSGTPPPTPPRGPMTTLQASDHPGQEAWGPSGQGLGAADVGVHS
What is the function of this protein?
May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.  Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region.  Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning.
What are the official names of this protein?
BLOC-2 complex member HPS6, Hermansky-Pudlak syndrome 6 protein homolog, Ruby-eye protein homolog, Ruby-eye-like protein, Ru.
What are the subcellular locations of this protein?
Microsome membrane. Cytoplasm, cytosol. Early endosome membrane. Lysosome membrane.
Protein: GLYA_DICT6
Sequence: MRYLPEVDPEIYEAIKSEEYREEYHLELIASENFVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCMYVDKVEDIARERVKTIYGAEHANVQPHSGSQANMAVYFVVLNPGDNVLGMNLAHGGHLTHGSPVNFSGKLYNFYFYGVDRDTEMINYDSVWNLAKEVKPKLIVAGASAYPRIIDFEKFAQIAEDVGAYFMVDMAHIAGLVAAGLHPSPVPYAHFVTSTTHKTLRGPRGGFILCKKEFAKEIDKAVFPGIQGGPLMHVIAAKAVAFKEAMTPEFKEYQKQIILNAKAMAEELMRLGYRLVSGGTDNHLMLVDLRDKGITGKEAEKALEEAGITVNKNAIPFDPQPPTVTSGIRIGTPALTTRGMKEDEMRYVARLIHEVLSNFKDSKVKEKVKKEVEELCKQFPIYRKEN
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTRA_BACSU
Sequence: MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNAYASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWVKAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATRKLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFENEGM
What is the function of this protein?
Catalytic subunit of the KtrAB potassium uptake transporter.  The 2 major potassium transporter complexes KtrAB and KtrCD confer resistance to both suddenly imposed and prolonged osmotic stress.
What are the official names of this protein?
Ktr system potassium uptake protein A, K(+)-uptake protein KtrA.
What is the protein family that this protein belongs to?
Belongs to the KtrA potassium transport family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PRSA_BACSU
Sequence: MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTNMKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLKEQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKGEKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYHIIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFNTSSTSNSTSSSSSNSK
What is the function of this protein?
Essential protein that plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.  Has PPIase activity but it is not essential for its function in vivo.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Membrane raft; Lipid-anchor. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Protein: GAT1_CANAL
Sequence: MYYRARHSLPYQKRMENLTWRMMYINNKSIFTNTNNAPKEIFEQSLDPEIDDFDYVAHIKKIGQFNQQKTQQQQDHLQSNLDNHNSIFADNTGFSNNNDRGSSGGGMTSISSLSKKRPAPFSPMIQPEKTTIIPTATNTMSQLSQQLNEFNKFNHPSQTSNFNDVNHHMEISTSHIAPTSSAFEFSLDPLAFEGPNQNFQPEPHHDFNTNSFDSMTSSYERPLFDDFLPRDHHNIQSSSVPTSASSFSTIVPKNTQFSTSASITSPTSTFSNQGNNSSNFHRLNSTVSITATPGNLLRQESMVSLPDYANHLRSMSQTPTMNSSNAPFSHSFNDGGSYFMNNFTGITLPSQPSPQPIHFDNKPKDDHFNTSLSVSQQQPSAKKSKRKSTITKSKKKAASPETTITSTGSTITTKSTNSNSTGKGTATGPAASNTGVSCTNCGTKTTPLWRRNPQGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRQRGNNNGSGNSSGTTNNSNNYNNKSISKKNEIDDGDDLNPTSITNNTGLTNNNNSKSPAKSKKKSNFDNNSNSALNNLDKSKLKINTNEITNISETTSNSSSPVINLNHGGRSSGVFGNTPDYLNGITSPAVSLVKSEIDNPHQLNNSNSNGMLMTMHQSSHQSSLSTTFDHEVESNNEGSNSSGVNTSTANNQDWDWLNMNY
What is the function of this protein?
Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources.  Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C. albicans.  Influences the filamentation process depending upon the nitrogen sources available.  Required for virulence in a mouse systemic infection model.
What are the official names of this protein?
Transcriptional regulatory protein GAT1.
What are the subcellular locations of this protein?
Nucleus.
Protein: CATV_NPVCD
Sequence: MNKIVLYLLIYVGTFSAAYDLLKAPSYFEDFLHNFNKNYSSKSEKLHRFKIFQHNLEEIINKNLNDTSAQYEINKFSDLSKDETISKYTGLSLPLQNQNFCEVVVLNRPPDKGPLEFDWRRLNKVTSVKNQGTCGACWAFATLGSLESQFAIKHDQLINLSEQQLIDCDFVDMGCDGGLLHTAYEAVMNMGGIQAENDYPYEANNGDCRLNAAKFVVKVKKCYRYVLMFEEKLKDLLRIVGPLPVAIDASDIVNYKRGVIRYCANHGLNHAVLLVGYAVENGVPFWILKNTWGTDWGEQGYFRVQQNINACGIQNELPSSAEIY
What is the function of this protein?
Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus.  May participate in the degradation of foreign protein expressed by the baculovirus system (By similarity).
What are the official names of this protein?
Viral cathepsin, V-cath, Cysteine proteinase, CP.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: RPPH_ECO7I
Sequence: MIDDDGYRPNVGIVICNRQGQVMWARRFGQHSWQFPQGGINPGESAEQAMYRELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLVSGDAEINMQTSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFASVVMSLQENTPKPQNASAYRRKRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: VGRG3_VIBCH
Sequence: MARLQFQLKVDGLEDESLVVRGFEGQESLSDSVWRCEPCYGFRYQVDLASALSNLTAEQFVDQTAHLTILRDGQVVQQINGIVRQLSKGDTGHRHTFYSLTLVPALERLSLRSNSRIFQQQSVPEIISILLQEMGIEDYAFALKRECAQREFCVQYRETDLQFLHRIAAEEGLVYSHLHEAQKHTLLFTDSSDSQPKLAKPVPYNALAGGEINLPYVVDLQFKTTAQVSHTELKDYSFKKPAYGFTQRTQGKDIAYQQPNYEHFDAPGRYKDDANGKAFSQIRLEYLRRDALLADAKSDEPLLLAGVRFDLQDHLDHAMNRDWLVVQANHQGTQPQALQEEGGSGATTYSNQLKLIPAHITWRARPCAKPQVDGPMIATVVGPQGEEIYCDNFGRVKVHFPWDRYSSSNEKSSCWVRVAQEWAGSQYGSMAIPRVGHEVIVSFLNGDPDQPIITGRTYHATNTAPYALPDHKTKTVLRTETHQGQGYNELSFEDQAGSEQILLHAQKDWDALIEHDHTEVIRHDQHLTVDNDRFTRIQRNQHLTVEGEVRSKIALDSSHEVGASLQHKVGQRIAVEAGKEISLKSGAKIVVEAGAELTLKAGGSFVKVDAGGVHLVGPAINLNAGGSAGSGSAYGGQLAAAPRMLAQAKPVAELVQPDIAASMQSGAARVIDVASLPTMMPSSANNTANDEPVAEEKTPERILKSDLLKPSDELEKLAKRQASAYRQGNHSDEVKLLQEALIKLGFDLGKAGADGDFGSKTKTAIEQFQKSYQPSHQTHPSYSIGAVDGIVGKGTLLALDEALMDGWVYENNIYQIWPLGKTSEKYESAGRGPGVISTGNGDYGGASYGCYQMSSNLGVVQKYIQSSKFKEFFSGLNPATKEFNVVWQDIASRYPQEFREEQHQFIKRTHYDIQIGHLRGKGLLFEHNRAAVHDLIWSTSVQFGGRTNLIFNALNGQNMESMTDKDIIILVQDYKLVNTERLFKSSPSWWSDLKKRAVSEKKALLELEIDGLEVDIK
What is the function of this protein?
Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:23362380, PubMed:23341465).  Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein Hcp.  Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity (PubMed:23362380).  Additionally, acts directly as an effector and targets the cell wall peptidoglycan layer of prey cells for degradation via its C-terminus (PubMed:23362380, PubMed:23341465).  Toxicity is counteracted by a cognate immunity protein TsiV3 (PubMed:23362380, PubMed:24699653, PubMed:23341465).
What are the official names of this protein?
Type VI secretion system spike protein VgrG3, Muramidase Vgrg3C.
What is the protein family that this protein belongs to?
Belongs to the VgrG protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: NU3M_CALCL
Sequence: MNALLAILINITLSLTLISVAFWLPQPNHYTEKASPYECGFDPMSSARLPFSMKFFLIGITFLLFDLEIALLLPIPWAMQYENMHMTTSTAFALITILTLGLAYEWLNKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RIMM_ENTFA
Sequence: MTDYLNVGKIVNTQGIKGEVRVISKTDFPEERYQKGAMLLLFQEKKAPIELVVKSHRKHKNFDILSFEGHPNINDVEKYRDGILKVAKDNLAELAEDEFYYHQIIGATVYDETGSELGKIKEILSPGANDVWVVQRPKKKDLLLPYIEGVVTKVDVENQRIDVDIPEGLIDDEN
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG14_BPP22
Sequence: MITFTPTRNIDLIEMVGNHPDIIAGSNNGDGYDYKPECRYFEVNVHGQFGGIVYYNEIQPMTFDCHAMYLPEIRGFSKEIGLAFWRYILTNTTVQCVTSFAARKFADGQMYCAMIGLKRVGTIKKYFKGVDDVTFYAATREELTELLNNGR
What are the official names of this protein?
Protein gp14.