PharMolix/UniProtQA huggingface dataset:
Protein: VKTHA_DENAN
Sequence: QPRRKLCILHRNPGRCYDKIPAFYYNQKKKQCERFDWSGCGGNSNRFKTIEECRRTCIG
What is the function of this protein?
Serine protease inhibitor homolog that blocks voltage-gated potassium channels (Kv1. 1/KCNA1, Kv1. 2/KCNA2, and Kv1. 6/KCNA6) (IC(50)=0. 4-150 nM) and facilitates neurotransmitter release.
What are the official names of this protein?
Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin, Alpha-DTX, Protease inhibitor 1 homolog, Toxin C13S2C3, Venom basic protease inhibitor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSGA1_ARATH
Sequence: MLRAKHIGKNYSSSLSPVLSPEHKPSLLESQAIGTVATAQANFMRVIVQDVANSVTSDDDNDSSKTGVELLCVVRAVLKKIRRRVLVGDKVLVGSIDWVDRRGMIENVFHRRSEILDPPVANVDHLLVLFSLDQPKLEPFTLTRFLVEAESTRIPLTLALNKTELISEEELETWKIRLRGWNYEPLFCSVGTKDGLDDIAFVLRDQTSVIVGPSGVGKSSLINVLRSNHGGGVVEDENWFEPMLGNKWFDDQRVGEVSSRSGRGKHTTRNVSLLPVSEGGYLADTPGFNQPSLLKVTKHSLAHCFPEIRNMIESEKCGFRDCLHIGEPGCVVKGDWERYPYYLQLLDEIRIREEFQLRTFGTKREDDVRYKVGDMGVKHAEPRLMPKKHRRESRKKTKQTMISELDEFEDEDSDLYIENDPIVQAIENENKRQ
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit (By similarity).  Required for embryo development (PubMed:15266054).
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA 1, mitochondrial, Protein EMBRYO DEFECTIVE 1688.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYDND_RHOPB
Sequence: MHRYRSHTCGALRESDIDQTVRVSGWCHRIRDHGGLLFIDLRDHYGLTQCVADPDSPAFKDAEKLRAEWVVRIDGKVRRRPEGTDNNDLPTGQVEIFITEIEVLGPAGELPLPVFGEQEYPEDIRLKYRFLDLRREKLHQNIMTRGAIVDSMRKRMKEQGFFEFQTPILTASSPEGARDFLVPSRIHPGRFYALPQAPQQYKQLLMMSGFDRYFQIAPCFRDEDPRADRLPGEFYQLDVEMSFITQDDVFAAMEPVITGVFEDFAKGKPVTKSWPRIAYADSLKKYGTDKPDLRNPIEMQNVSEHFRGSGFKVFARMLEEERNQVWAIPGPGGGSRAFCDRMNSWAQGEGQPGLGYIMWREGGEGAGPLANNIGPERTAAIREQLGLKAGDAAFFVAGDPSKFVRFAGLARTRLGEELNLVDKERFELAWIVDFPMYEYNEDDKKVDFSHNPFSMPQGGMDALLNQDPLTIKAFQYDITCNGFEIASGGIRNHRPEAMVKAFEIAGYGEQEVVDRFGGMYRAFQYGAPPHGGMAAGVDRIVMLLCGTNNLREISLFPMNQRAEDLLMGAPSDVTPKQLRELHIRLNLPEN
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CINA_BACC3
Sequence: MNAEIIAVGTELLLGQIANTNAQFLSEKLASIGINVYYHTVVGDNNKRLQQAIEVAEGRADMLIFTGGLGPTKDDLTKETIASSLAEELVYDEKALASISDYFKRTGREFTENNKKQALVLDGATVFANDHGMAPGMGLNKNGKVYILLPGPPKEMKPMYVSYVEPFLRNFTTGENIYSRVLRFFGIGESQLEVKVQDLIDGQTNPTIAPLANDGEVTLRLTAKHQNVDEAEKLIQHVEDLILERVGEFFYGYDQEFLHDKAIELLKKKGLTLSCAESLTGGLFGNQVTESAGVSSVFKGGVICYHNDVKQHVLHVPEEVLFTDGAVSKECARYLAENVKELLEADIGISFTGVAGPDASEHKEPGTVFVGLAIKDEPTVVFPLNLSGSRQQIRERSAKYGFYHLYKKLEEI
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: CYSG_ECOUT
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDALNQRVSEAAESRRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMGERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLIRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEYGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: NET1_HUMAN
Sequence: MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA
What is the function of this protein?
Netrins control guidance of CNS commissural axons and peripheral motor axons.  Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively.  Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977).  Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).  It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis.  Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).
What are the official names of this protein?
Netrin-1, Epididymis tissue protein Li 131P.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Mainly secreted.
Protein: PDX1_CERNC
Sequence: MASNGTSVSPFRSQKNAAMAVNDTPANGHAEPSTITAASKTNTTKITSQNDPQSSFAVKVGLAQMLKGGVIMDVVNAEQARIAEEAGACAVMALERVPADIRKDGGVARMSDPQMIKDIMNAVTIPVMAKSRIGHFVECQILQAIGVDYIDESEVLTPADPVNHIDKSVYNVPFVCGCKNLGEALRRISEGAAMIRTKGEAGTGDVVEAVRHMQTVNAEIAKASSASDADLRMMARELQCDYNLLKQTAQLKRLPVVNFAAGGIATPADAALMMQMGCDGVFVGSGIFKSGDAAKRAKAIVQATTHYNDPKVLAEVSSGLGEAMVGINCDKLPETQKLATRGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by PDX2.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.  Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PDX1, PLP synthase subunit PDX1, Singlet oxygen resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: LOLB_VIBPA
Sequence: MTLRSFLIFFLSSLILAGCSSVPESVTSVEWQAHEQRLETIHDFQATGKLGYIGPDQRQSLNFFWKHSTALSQLRLTTVLGQTALKLTITPQGATVETYDDQVLSARNANQLIYRLTGLMMPVDHMPDWLLGLPTDADTFQLSPANTLQTLDKQIGLNDWKIAYERYGDVEWHEQTLPLPNKLKLTTSDVKINLVITKWNITQ
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: YIDC_ECOLU
Sequence: MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQAQQTTQTTTTAAGSAADQGVPASGQGKLISVKTDVLDLTINTRGGDVEQALLPAYPKELNSTQPFQLLETSPQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKDAYVLAEGQNELQVPMTYTDAAGNTFTKTFVLKRGDYAVNVNYNVQNAGEKPLEISTFGQLKQSITLPPHLDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNISSKGGWVAMLQQYFATAWIPHNDGTNNFYTANLGNGIAAIGYKSQPVLVQPGQTGAMNSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRISQEMMALYKAEKVNPLGGCFPLLIQMPIFLALYYMLMGSVELRQAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL22_PROMP
Sequence: MTKTPEMTKTAIAHGKYIRGSASKVRRVLDQIRGKSYRDALIMLEFMPYRSTDPITKVLRSAVANAEHNLGMDPSSLVISSASADNGPVMKRFRPRAQGRAFSIKKQTCHISISVESAPNQTNTEAQN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: FS2P1_MOUSE
Sequence: MKLEEKLEHNESLVGKSRPCLHDTHQANGKPIANGNPTANGKVEVYEKQEANGKGNRLGKCLNLYTWQEIQRHSQEADQWLVIDRKVYNVTDWAGKHPGGRRVLNHYAGQDATDAFRAMHLDLGMVKLYLKPLLIGELSPEEPSQEKNKNAQLVEDFRELRKTLEAMNMFSANLRFFFLHLAQILILEISAWLILHHFGSSWLVTILISFLLTVSQAQCSFLQHDLGHLSMFKKSKWNHLMHKFVMCHLKGLSADWWNYRHFQHHVKPNIYPKDPDIDVGPLFLVGDTQPIKYGKKKIKYIDYEKQHLYFYMVALPFLMPVYFNLQSMQVMYLRKYWMDIAWVSSFYIRYFITFGPFYGIFGTVLLIYLVKFIESPWIAYVTQMSHIPMKMSSEENHDWLSTQVVATCNIEQSFFNDWFTGHLNFQIEHHLFPTMPRHNYHKVAPLVKSLCAKHGLQYINKPILKAFGDIVRSLKKSASLWMNAYYE
What are the official names of this protein?
Fatty acid desaturase 2-like protein FADS2B, Fatty acid desaturase 2B, pseudogene.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: IDI2_RICRO
Sequence: MLKDQNLDIERKQDHIEINLTQNVESTLKSGFESIHFIHNALPELNYDSINTTTTFLGKSLQAPILISSMTGGTTRARDINYRLAQVAQKAGIAMGLGSMRVLLTEPDTIKTFAVRHIAPDIPLLANIGAVQLNYGVTPKECQYLVDAIKADALILHLNVLQELTQPEGNRNWEKLLPKIREVVHYLSIPVIVKEVGYGLSKKVAESLIDAGVKVLDIAGSGGTSWSQVEAYRATNSLQNRIASSFINWGIPTLDSLKMVREVSKDIPIITSGGLKSGIDGAKAIRIGANIFGLAGQFLKAADTSESLLFEEIQLIIEQLKITMLCTGSRTLKDLAKAEIRL
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7S_HAEIN
Sequence: MARKPASSQDFETTLVQLENIVTHLENGDLPLEEALKEFEQGVQLAKLGQERLQQAEQRIQILLQKTEDAPLNDYKGNDYEGNA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_COXBN
Sequence: MTVKKIALVAHDRMKKELIEWIKKHQNLLKHHELYATGSTGQAIEKTLNVTVTKMESGPLGGDLQLGAKIVNKEIDILIFFWDPLEAQPHDPDVRALLRIAVVWNLPVACNASTADYLLTSPLFDSDYHPETPDYEAYRNRII
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: ENGB_BORBR
Sequence: MSLLHRASFYISAARLDQLPPAGAPEVCFVGRSNAGKSSAINVLCNQRRLAFSSKTPGRTRLINMFGLPDPLAPGEQLGFLVDLPGYGYASVAHREKEKWADILGGYLRDRASLAGIVLLIDIRRGVTDLDRRLTNFIAPTGRPVLALLTKADKLPYGQRMRTVFAVRKDLADIGALHMVPFSSTERIGLEEAGAHIENWISPKVVP
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: B25_VACCW
Sequence: MDEIVRIVRDSMWYIPNVFMDDGKNEGHVSVNNVCHMYFTFFDVDTSSHLFKLVIKHCDLNKRGNSPLHCYTMNTRFNPSVLKILLHHGMRNFDSKDEKGHHYQSITRSLIY
What are the official names of this protein?
Truncated ankyrin repeat protein B25.
What is the protein family that this protein belongs to?
Belongs to the orthopoxviruses B25 protein family.
Protein: COAD_STAHJ
Sequence: MAKTKAVIPGSFDPITYGHIDIIERSAGRFDELHICVLKNSNKTGTFNIDERMALIEESVKHLSNVEVHNYNGLLVDFCDKIGAQTIIRGLRAVSDFEYELRLTSMNKKLNSNVETMYMMTSTNYSFISSSVVKEVAQYKADISDFVPPNVEKALKEKFKK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_PHEZH
Sequence: MPGKTLYDKIWDAHVVAEQDGEAILYIDLHLIHEVTTPQAFAGLRVAGRPVRRPDRTLAVADHNVPTEGQGLGIDAVADEEARLQLQTLAKNVAEHGIEFFSMGDVRNGIVHVVGPEQGRTQPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLRQKKAKNMRVRIEGEPAPGVGAKDFALAVIGEIGTAGGTGYVIEYAGSAVRALSMEGRMTLCNLTIEGGAKAGLIAPDEMTYAYLQGRPAAPKGGAWEMALDYWKGFHSDEDAVFDREIVLDAAKIAPTVTWGTSPEDVVAVTGLVPSPDSFGTPDKRASAARALEYMGLTAGQPITEAKVDVVFIGSCTNSRIEDLRAAAAIVAKALEGGRKVAPGVRAMVVPGSGLVREQAEAEGLDEVFKAAGFDWREPGCSMCLGMNPDRLAPGERCASTSNRNFEGRQGRGGRTHLMSPAMAAAAAIAGHIADVREFL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: Y1386_HAEIN
Sequence: MYLLMAIFSGIKPNLYWNTKSDIFVDVKIEDIQQQLHFTFNEVNGHIDTNCYAVPREIAQKTSYSWNTSLIGDRSFLSALKSLGLIGQTSGKYTVKYRADFNKLIAVRRVFPQLSLSDEDNNNISAKILEVINQQNIEYYGGRPWAKE
What are the official names of this protein?
Uncharacterized protein HI_1386.
Protein: C11B2_RAT
Sequence: MGACDNDFIELHSRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSMFKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
What is the function of this protein?
A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone.  Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule.  Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
What are the official names of this protein?
Cytochrome P450 11B2, mitochondrial, Aldosterone synthase, ALDOS, Aldosterone-synthesizing enzyme, CYPXIB2, Corticosterone 18-monooxygenase, CYP11B2, Cytochrome P-450Aldo, Cytochrome P-450C18, Cytochrome P450-Aldo-1, Steroid 11-beta-hydroxylase, CYP11B2, Steroid 18-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: RS3_STUS1
Sequence: MGQKVHPTGIRLGIVKEHTSVWYADGRTYADYLLADLNVREYLQDKLKSASVSRIDIHRPAQTARITIHTARPGIVIGKKGEDVEKLRQDLTKQMGVPVHINIEEIRKPELDAMLVAQSVAQQLERRVMFRRAMKRAVQNAMRIGAKGIKIQVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTYEAHTTYGVIGVKVWIFKGEVIGGRHEELKPQAPAPRKKAAK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: AMT6_ALTAL
Sequence: MKTAHTIVVFGGDYCGPEVMKEGLKVLSEIERQNPDVKLELIHHLVGGAAWDVHGENITTAALSDATSASAVLLGAVGGPKWAKHAIPVEWGLGRLRKALDAFGNLRPVNFAAPSLISRSSLKPKVCTGTEILIVRELTGGVYFGPRSEHDGSFDQASDTDVYTRKEIERVTRLAGSLAMARDPPLAVTSLDKANVLAACGRLWRGVVSEVMAAEFPEIELRHMLIDSAAMVMALNPTKLNGVVLASNMFGDIISDQASAIPGSIGLLPSASLCSIPERGQESSRIRGLYEPIHGSAPDIAGKGIVNPIGMILSVAMMCRLSLDMGAAATSIEAAVRDTLEVGICTPDIGGTASTSEVGDAVVAALVRIFDKH
What is the function of this protein?
3-isopropylmalate dehydrogenase; part of the gene clusters that mediate the biosynthesis of AM-toxins, host-selective toxins (HSTs) causing Alternaria blotch on apple, a worldwide distributed disease (Probable).  AM-toxins are cyclic depsipeptides containing the 3 residues 2-hydroxy-isovaleric acid (2-HIV), dehydroalanine, L-alanine which are common for all 3 AM-toxins I to III.  The fourth precursor is L-alpha-amino-methoxyphenyl-valeric acid (L-Amv) for AM-toxin I, L-alpha-amino-phenyl-valeric acid (L-Apv) for AM-toxin II, and L-alpha-amino-hydroxyphenyl-valeric acid (L-Ahv) for AM-toxin III (Probable).  AM-toxins have two target sites for affecting susceptible apple cells; they cause invagination of the plasma membrane and electrolyte loss and chloroplast disorganization (PubMed:22846083).  The non-ribosomal peptide synthetase AMT1 contains 4 catalytic modules and is responsible for activation of each residue in AM-toxin (PubMed:10875335).  The aldo-keto reductase AMT2 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV), one of the precursor residues incorporated by AMT1 during AM-toxin biosynthesis, by reduction of its ketone to an alcohol (PubMed:15066029).  The cytochrome P450 monooxygenase AMT3 and the thioesterase AMT4 are also important for AM-toxin production, but their exact function within the AM-toxin biosynthesis are not known yet (PubMed:17990954).  Up to 21 proteins (including AMT1 to AMT4) are predicted to be involved in AM-toxin biosynthesis since their expression ishighly up-regulated in AM-toxin-producing cultures (PubMed:17990954).
What are the official names of this protein?
3-isopropylmalate dehydrogenase AMT6, AM-toxin biosynthesis protein 6.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: PROA_BACFR
Sequence: MNLNDTFAAVQAAGRHLALLPDDRINQILNAVAEAALEQTSYILSENRKDLERMSPDNPKYDRLRLTEERLRGIASDIRNVATLPSPLGRILKESIRPNGMRLTKISVPFGVIGIIYEARPNVSFDVFSLCLKSGNACILKGGSDADYSNRAIVEVIHQVLRQFNIDTHMVELLPADREATRELLHATGYVDLIIPRGSSALINFVRQNATIPVIETGAGICHTYFDEYGDTAKGAAIIHNAKTRRVSVCNALDCVIVHESRLSDLPLLCEKLKADKVIIYADPSAYQALEGHYPAGLLKPATPESFGTEFLDYKMAIKTVNSFENALGHIQEYSSRHSESIVTENPERAALFTRMVDAACVYTNVSTAFTDGAQFGLGAEIGISTQKLHARGPMGLEEITSYKWIIEGDGQTRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGL1_MAIZE
Sequence: MQFALALDTNSGPHQIRSCEGDGIDRLEKLSIGGRKQEKALRNRCFGGRVAATTQCILTSDACPETLHSQTQSSRKNYADANRVSAIILGGGTGSQLFPLTSTRATPAVPVGGCYRLIDIPMSNCFNSGINKIFVMSQFNSTSLNRHIHRTYLEGGINFADGSVQVLAATQMPEEPAGWFQGTADSIRKFIWVLEDYYSHKSIDNIVILSGDQLYRMNYMELVQKHVEDDADITISCAPVDESRASKNGLVKIDHTGRVLQFFEKPKGADLNSMRVETNFLSYAIDDAQKYPYLASMGIYVFKKDALLDLLKSKYTQLHDFGSEILPRAVLDHSVQACIFTGYWEDVGTIKSFFDANLALTEQPSKFDFYDPKTPFFTAPRCLPPTQLDKCKMKYAFISDGCLLRECNIEHSVIGVCSRVSSGCELKDSVMMGADTYETEEEASKLLLAGKVPVGIGRNTKIRNCIIDMNARIGKNVVITNSKGIQEADHPEEGYYIRSGIVVILKNATINDGSVI
What is the function of this protein?
This protein plays a role in synthesis of starch.  It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic/amyloplastic, ADP-glucose pyrophosphorylase, ADP-glucose synthase, AGPase S, Alpha-D-glucose-1-phosphate adenyl transferase, Shrunken-2.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast. Note=Found in the chloroplast in leaf. Found in the plastid in the developing endosperm.
Protein: RS3A_MAGO7
Sequence: MAVGKNKRLSKGKKGLKKKTQDPFARKDWYGIKAPAPFNIRDVGKTLVNRSSGMKNANDALKGRIFEVSLADLQKDEDHAFRKIKLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQSLIEANVTVKTTDDYLLRLFAIAFTKRRPNQIKKTTYAASSQIRAIRRKMTEIIQREASTCTLQQLTNKLIPEVIGREIEKATQGIYPLQNVHIRKVKLLKQPKFDLGGLLALHGESTTDEQGQKVEREFKERVLEEV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y398_ARCFU
Sequence: MIFDVYSNYYSRHISRPSIGLGIGLVSSITSPIDFGFSASASAENTVKCSWYKETEQGFAKGLRLEYNDIYAMKPGDRIATYFHVYTEEDLNSANPVWYPMKAKILRIPVYEYSSTSPNAHITDVGSDYPIYAWIEHVDDEHR
What are the official names of this protein?
Uncharacterized protein AF_0398.
Protein: NKX24_MOUSE
Sequence: MSLSPKHTTPFSVSDILSPIEETYKKFGGVMDGAPPGLGAPLGAAAYRAPPSGPSSQAAAVAAGMQPPHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHSAMGSYCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANTDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPPPSPRRVAVPVLVKDGKPCQNGAGTPTPGQGGQQPQAPTPAPELEELSPSPPALHGPGGGLAALDAATGDYGGGVLGANLLYGRTW
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
Homeobox protein Nkx-2.4, Homeobox protein NK-2 homolog D.
What is the protein family that this protein belongs to?
Belongs to the NK-2 homeobox family.
What are the subcellular locations of this protein?
Nucleus.