PharMolix/UniProtQA huggingface dataset:
Protein: TRUA_ACISJ
Sequence: MRVALGVSYNGQAYNGWQSQPSANTVQDRLEAALGRFATQEVHTICAGRTDAGVHGLMQVVHFDTELQRAPFSWVRGTNTFLPADIAVQWAQPVPDAFHSRACAVARRYAYVLLQSPVRPSVDAGRVGWVFHALDEQAMHKAVQHLLGEHDFTSFRASACQAKSPVKTLHRIDITRRAPPAGESTGTHGCVPCYWRFEFEGNAFLHHMIRNIMGCIVAIGQGLYPPEWMRTVLEARSRDAAAPTFSPDGLYFQGPVYGAEWGLPTRTAAYDWLP
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: DCSC_STRLA
Sequence: MIRMRTPSTLPFTKMHGAGNDFVVLDLRDGPDPSPELCRALADRHKGVGCDLVLGIREPRSARAVAAFDIWTADGSRSAQCGNGARCVAAWAVRAGLARGPRFALDSPSGTHEVDVLDADTFRVALAVPRFAPESIPLFGHDGEQDLYEADLGDGTRVRFAAVSMGNPHAVIEVDDTATAPVARVGRAVQASGLFLPTVNVGFARVESRDRVHLRVHEYGAGETLACGSGACAAAAVLMRRGRVDRNVSVVLPGGELRISWPDDAADVLMTGPAAFVYEGTFLHASV
What is the function of this protein?
Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent.  Catalyzes the stereoinversion of O-ureido-L-serine to O-ureido-D-serine.
What are the official names of this protein?
O-ureido-serine racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG12_KLUMD
Sequence: MNSGVLLSESETDTSETSERQSGLLSAQGSIKGKLEEFSAKLDRLRLDDENSEEEHALKSQSVSVNSEGNISRSASASASASASASAKLRNSQSPVQEYTSDTNPETDASFRVKIRLRPIGSIPQIQPRVCQISSHQNFSALVKFLCKRLKRNHVHCYINNAFAPSLNQTIGDLWSQFKTNDELIVSYCETVAFG
What is the function of this protein?
Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy (PubMed:26442587).  Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function (By similarity).  The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).  ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity (By similarity).
What are the official names of this protein?
Ubiquitin-like protein ATG12, Autophagy-related protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG12 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre- autophagosomal structure (PAS) (By similarity). Ultimately, the IM expands to become a mature autophagosome (By similarity). Localizes also to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS) (By similarity).
Protein: CAD10_CHICK
Sequence: MTIQQVLLLLLLWMWLLHPCRTEMLFRRTPDLRPKGFVGRTSGSDGKALHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARIIYSILQGQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTIHLRIPESSPVGTPIGSIKATDADTGKNAEVEYRIIDGDGTDMFDIVTQRDTQEGIITVRKPLDYETRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISVEDVDEPPVFSRSSYLFEVHEDIELGTIIGTVMARDPDSASSPIRFSLDRHTDLDRIFNIHSGNGSIYTSKPLDREISQWHNLSVIAAEINNLKDTTRVPVYVRILDVNDNAPQFAVFYDTFVCENARAGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRRNGFSRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSRGNMQSCNAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEDKKLRRDIIPETLFVPRRTPSAPDNTDVRDFINQRLKEHDSDPSAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDAS
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
What are the official names of this protein?
Cadherin-10.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: DEGS_BREBE
Sequence: MPFKGLVVQVADPQTLDKIIDKTLDTVGKSREQIFEISEQSRNEYVSLEQELQEVRMKVAEIIDQSDRAEVHARFARNRLAEVSKQFHRYSNEEIRKVYEQANELQVKLALLQQEEQQLRDRRDAIERRLLNLKDTIERAEELVGQMTVVYNFLTGDLRQVGEALEDAREKQAFGLQIIQAQEEERRKLSREIHDGPAQMMANVLLRSELVERIYHDKGIDEALKEIRDLRKMVKSSLAEVRRIIYDLRRMALDDLGLIPTLKKYVKTFEEHTGIFVDFKHIGKGERFPEHVEIALFRLVQEALQNTRKHAKASHVHVKIEEQKTKFTVVIKDNGKGFDQTEKKEGSFGLVGMKERVNMLKGQLVIRTKPNDGTTIIISIPITTEE
What is the function of this protein?
Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase.  Acts as both a protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to DegU, and a protein phosphatase that dephosphorylates phospho-DegU (By similarity).
What are the official names of this protein?
Signal transduction histidine-protein kinase/phosphatase DegS.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNPG_DROME
Sequence: MERPALLQNGEIGTMESPTTRLASKPFPKPFSIESLIANQTPATATPPSPPEERDQEQEAEQEQELSARAMVASSALGLTQFPLYNPWLHGYFAQNHERLTHLIAGGCYLPSSPAGHPAAQQPQAQAQPQPPPPHPPTHALEKQLPPTLPHPLDTRFLPFNPAAAGVAPTDLSYRRLAELMNQDYVHSLSVHARLQHMAAAGRMHEDQANPGMAQLQEPTPPQAHSSPAKSGSHSPMEPALDVGMDEDFECSGDSCSDISLTMSPRNYNGEMDKSRNGAYTNSDSEDCSDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKRVKAGLTSHGLGRNGTTSGTKIVVPIPVHVNRFAVRSQHQQLEKMCLSGPKPDLRKKLSAEAIGGFEKFSGSTNASSPSGGPVGLGVGVGVGVGVGLGVSTPLSLARSIY
What is the function of this protein?
Plays a regulatory role in neural branching of the tracheae: segment-specific aspects of these neural branching patterns appear to be generated by homeotic regulation of expression.  May have a role with oc/otd in the postembryonic development of the brain.
What are the official names of this protein?
Homeobox protein unplugged.
What are the subcellular locations of this protein?
Nucleus. Note=In tracheal precursor cells as they migrate and extend.
Protein: NUOI_BURL3
Sequence: MSAIQHFFKTFFLTELLQGLALTGRYTFKRKVTVQFPEEKTPISPRFRGLHALRRYENGEERCIACKLCEAVCPAMAITIESETRADNTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETQILEYHGEKRGDLYFTKEMLLAVGDRYEKDIAAAKAADAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LIPA_COREF
Sequence: MTIAPEGRRMLRVEARNSQTPIETKPRWIRNQVKNGPEYKDMKERVAGASLHTVCQEAGCPNIHECWESREATFLIGGANCSRRCDFCMINSARPEPLDRGEPLRVAESVREMRLNYSTITGVTRDDLPDEGAWLYSEVVRKIHELNPNTGVENLVPDFSGKRDLLQEVFESRPEVFAHNLETVPRIFKRIRPAFRYDRSLDVIRQARDFGLVTKSNLILGMGETREEISEALRDLHSAGTDIITITQYLRPGPLFHPIERWVKPEEFLELSDEAYEIGFAAVMSGPLVRSSYRAGKLYAQALKFRGEELPANLSHLAETTEGPTTQEASSLLERYGASEDAPVIPRG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STING_DROEU
Sequence: MIKEMAIANNADEVDNEVRAEKGRKCFYLKKMIGDYIGNTVRIVATVVLADFLQRLYRSVVEYVHCSKYYLPEDRLWTILRRSCTYSNKSRYLVMGFILIGFLRISVSGNYKDVVPTFKFLAYMPLYWIFSNLGHSTLTYSSWVRDSHGLDYAAGMASNYFHGYLKLSLPERKADGLLHRMNVYEDKYNVTFGIKRLIILIPDEMFINGVIQSRILEKATPLETQFINRAGVNRPFKHAVYRLAEKVNGKTYYFAMEGATPMLSFFEAMHSNFSATWQMKELKREIWLKFYTHLNELIKTWPETRNLVELIIYNSHDTKGDLVDVGEMLKSHMELKTKNIDEMIG
What is the function of this protein?
Facilitator of innate immune signaling that binds cyclic dinucleotides produced in response to infection by bacteria and/or viruses, and promotes the activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:34261127).  Recognizes and binds cyclic di-GMP (c-di-GMP), a cyclic dinucleotide messenger produced by bacteria such as L. monocytogenes, leading to activation of the peptidoglycan recognition protein (IMD) signaling pathway and activation of Rel (Relish) (By similarity).  Innate immune response is triggered in response to double-stranded RNA from viruses delivered to the cytoplasm: Sting acts by specifically binding cyclic dinucleotides 3',2'-cGAMP and 2',3'-cGAMP produced by cGLR1 and cGLR2 in response to RNA virus in the cytosol (PubMed:34261127).  Has a strong preference for 3',2'-cGAMP compared to other cyclic dinucleotides such as 2',3'-cGAMP or 3'3'-c-di-GMP (PubMed:34261127).  Upon binding to 3',2'-cGAMP, activates an antiviral immune response, leading to the activation of Rel (Relish) (PubMed:34261127).  Activated in brain in response to Zika virus infection, leading to autophagy (By similarity).
What are the official names of this protein?
Stimulator of interferon genes protein homolog.
What is the protein family that this protein belongs to?
Belongs to the STING family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: JTB_HUMAN
Sequence: MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI
What is the function of this protein?
Required for normal cytokinesis during mitosis.  Plays a role in the regulation of cell proliferation.  May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.  The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.  Increases AURKB activity.  Inhibits apoptosis induced by TGFB1 (By similarity).  Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
What are the official names of this protein?
Protein JTB, Jumping translocation breakpoint protein, Prostate androgen-regulated protein, PAR protein.
What is the protein family that this protein belongs to?
Belongs to the JTB family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Mitochondrion. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Protein: Y306_STRT1
Sequence: MKNNSIRTVVATGIGAALFIIIGMFVNIPIFGNTSIQLQYAVQALFSVIFGPITGFFMGFIGHALKDGIQYGNISWAWVLASGITGLVIGLFGKKYDVTMGKFSVMSMIWFNLAQALGLLIAYGVVTPIGDKIQFAQAWSYLYAQSFVAGVANFITIAIGGTLLLAIYASSRTQSGSLTKD
What are the official names of this protein?
UPF0397 protein str0306.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL17_PROM5
Sequence: MRHQLRIPLLSKPADQRKALLRGLTTQLIREGRVTTTKARAKALRNETERMISLAKEGTLAARRRAIGYIYDKKLVHSLFEKAQERYGDRNGGYTRIVRTVARKGDNAQMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: TGT_YERPE
Sequence: MKYELQKTDGRARRGRLVFERGVVETPAFMPVGTYGTVKGMTPEEVKETGAQILLGNTFHLWLRPGQEIMKLHGDLHDFMQWHGPILTDSGGFQVFSLGAMRKIKEEGVHFKNPINGDSVFLSPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAARSRQRFDELNNKNALFGIIQGGVYEDLRDVSVKGLVDIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPEDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKDDTATLDEHCDCYTCRHYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRQAIEEGKLEHFVEDFYGRIGKPVPPLNV
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NU4C1_MICAN
Sequence: MNLTNFPWLTAIILFPIVAALLVPIIPDKDGKTVRWFALTVGLIDFALIIYAFYSSYDFANPNLQLVESYQWLPEIDLRWSLGADGLSMPLIILTGFITTLAILAAWPVTFKPKLFYFLMLLMYGGQIAVFAVQDLLLFFLVWELELVPVYLILSIWGGKRRLYAATKFILYTAGGSLFILVAALTMAFYGDTVSFDMVTIAGKDFPLKLQLFLYAGFLIAYGVKLPIFPLHTWLPDAHGEATAPAHMLLAGILLKMGGYALLRMNMGMLPDAHAVFAPVLVILGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVLIGMASFTDIGTSGAMLQMISHGLIGASLFFMVGCTYDRTHTLMLDEMGGVGKKMKKVFAMWTTCSLASLALPGMSGFVAELMVFIGFATSDAYSPTFRVIIVFLAAIGVILTPIYLLSMLREILYGPENKELEEHHALVDAEPREVFIIASLLVPIIGIGLYPKVATTIYDATTNKLTALVRNSVPSLVQQAKAKTPSFSLYSLKAPEI
What is the function of this protein?
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4 1, NAD(P)H dehydrogenase I, chain 4 1, NDH-1, chain 4 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RISB_XYLFM
Sequence: MSHYEGDLRPAGARFVIVCSRWNARITDALVAGACHSLVDNGVPDDAVDVVRVPGAWEIPIVANLLAQAGQHAAIIALGCVVRGDTRHYEHVADLCAEGMMSVQMQTGVPVLNGVLAVECIKDAEMRAGGSHGNKGAETALAALEMVSLLEKLP
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: MU161_SCHPO
Sequence: MIFYDKLKPADVLVIGSADGRVIEAIEYIADLHKQHGFKFAICLGNLFSHKRTTSADVVKLKNEKVKVPIPVYFGVGTAGLPESIISHMAMYGPEVAPNLFCMGICGFMKTFYKFTIAQLGGSYNEEKYYQPPEKFEQSLNEKCFHRSDVQKLSKRCDILFSSEWPEDVQENSTLPERKLPKGCMPLAALAANCMPQYFFVPGPVYYEREPYKNSAAINVNTGTVTHFVALAPFKNSKNEKFSYAFTLYPLTTEYMQPAPPNCTASPFEHRPIPLKRASEDQIIPQQTNKFHKSKSSTALFKSKKDSSSSLNKMHKSESHSALNNLHKSESGTSLNNRRSKVGPGSCFFCLSNPNVALHLIVAIGNEAYMALPKGPLTTTASNTPALASSGHVLIIPIAHASALSTLSDTSYEKTLNEMNRFRKAVTDMYNACDSDALVYEISRANGVHLHWQMIPIPKISSHRIESVFLEMAKEAGYDFEERDVEPHELNYFRVFLPSGKILIHRLQLRERFDLQFGRRAAAKILGLEDRVDWRKCVQTEDEEKAESEAFKMCFKPYDFT
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
CWF19-like protein mug161, Meiotically up-regulated gene 161 protein.
What is the protein family that this protein belongs to?
Belongs to the CWF19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEUC_CAMJ8
Sequence: MAKTLYEKVFDAHVVYEGKNELPILYIDRHLIHEVTSPQAFSGLKMAKRRMARADLTLATIDHDVSTKSIDLNACSDMAKEQITTLMQNTKEFGVRLLGLGDKNQGIVHIVGPELGFTLPGVTLVCGDSHTATHGAFGALAFGIGTSEVEHVMATQTLKQAKLKTMKIECKGQFQKGVYAKDLILYLIAQYGTAKGTGYAIEFCGELIRKLSMEARMTLCNMAIEFGAKVGMIAPDEITFEYIKGKEFAPKGEEFQKYCEYWKSLRSDEGAKYDESITLDVSKIKPQISYGTNPSQVIGIDEKIPKISDFKNQSEQKSLLDALSYVNLEQDQVIEGVKIDIVFIGSCTNGRLEDLKIAADILKGHKIHKNVKALIVPGSMQVRKEAENLGLDKIFIEAGCEWRYAGCSMCLGMNDDKANSGQRVASTSNRNFVGRQGKGSITHLMSPASAAACAIEGVICDNRKYLGV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: ILVD_SHIF8
Sequence: MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDSQSDQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVKNVLGLTLPQTLEQYDVMLTQDDAVKNMFRAGPAGIRTTQAFSQDCRWDSLDDDRANGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGSIGLIEDGDLIAIDIPNRGIQLQVSDAELAARREAQEARGDKAWTPKNRERQVSFALRAYASLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CISY_XENLA
Sequence: MSLISAGRVCARILGAKNSPCALIAARQASSSTNLKDVLSDLIPKEQTRIKNFKQQHGKTVIGQVTVDMVYGGMRGMKGLVYETSVLDPDEGIRFRGYSIPECQKLLPKAPGGEEPLPEGLFWLLVTGEVPNQDQVNWISKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGVNKAKYWELVYEDSMDLIAKLPCVAAKIYRNLYREGSSIGAIDSNLDWSDNFTNMLGYTDQQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFSAAMNGLAGPLHGLANQEVLVWLTSLQKDLGGEVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPDDPMFKLVAQLYKIVPNILLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLSQLIWSRALGFPLERPKSMSTDGLMQLVGSKSG
What are the official names of this protein?
Citrate synthase, mitochondrial, Citrate (Si)-synthase.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: DUS15_MOUSE
Sequence: MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIISIHESPQPLLQDITYLRISVSDTPEVPIKKHFKECVHFIHSCRLNGGNCLVHCFAGISRSTTIVIAYVMTVTGLGWQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKLRRQLEERFGEIPFRDEEDLRALLPLCRRCRQGSATSAASATTASSAAEGTLQRLVPRSPRDSHQPLPLLARVKQTFFCLPRCLSRKGGK
What is the function of this protein?
May play a role in the regulation of oligodendrocyte differentiation (PubMed:22792334).  May play a role in the regulation of myelin formation (By similarity).  Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).
What are the official names of this protein?
Dual specificity protein phosphatase 15, Dual specificity protein phosphatase T-DSP10.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: CCA_SALTY
Sequence: MKIYLVGGAVRDALLGLPVKDKDWVVVGATPQEMLDAGYQQVGRDFPVFLHPQTHEEYALARTERKSGSGYTGFTCYAAPDVTLEADLQRRDLTINALARDDAGQIIDPYHGRRDLEARLLRHVSPAFGEDPLRVLRVARFAARYAHLSFRIADETLALMREMTAAGELEHLTPERVWKETENALTTRNPQVYFQVLRDCGALRVLFPEIDALFGVPAPAKWHPEIDTGVHTLMTLSMAAMLSPQLDVRFATLCHDLGKGLTPKNLWPRHHGHGPAGVKLVEQLCQRLRVPNDLRDLAKLVAEYHDLIHTFPILQPKTIVKLFDAIDAWRKPQRVEQIALTSEADVRGRTGFEASDYPQGRWLREAWQVAQAVPTKEVVEAGFKGIEIREELTKRRIAAVANWKEKRCPNPAS
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.  Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities.  These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
What are the official names of this protein?
Multifunctional CCA protein.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Protein: PTH_PARDP
Sequence: MKLIVGLGNPGAKYAANRHNVGFMAVERIAGDHGFSPWRARFQGEIAEGRLGETRVTLLKPATFMNLSGQSVGEAMRYLKLAPQDVIVLHDELDLAPGKVRLKTGGGHAGHNGLRSLHQHIGEGYRRLRIGIGHPGDKDRVAGYVLSDFAKAEQAGLDDLLRGISDGAAALAAGDDARFMNAVAARVAPARNSGTRPDNPGKGSPEKPAAKPANDPIAEPPSLSDRLRALTERFR
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_SINMW
Sequence: MAMTDPLGDMLTRIRNGAARRKSSVSTPASKLRARVLDVLQAEGYIRGYSEVEFGNGKAELSIELKYYEGASVIREIARVSKPGRRVYVSVKSIPQVANGLGITILSTPKGVMADHQAREQNVGGEVLCSVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: HBEAG_HBVB6
Sequence: MQLFHLCLIISCSCPTVQASKLCLGWL
What are the official names of this protein?
Truncated HBeAg protein.
Protein: KDPC_ECOL5
Sequence: MRGLRPALSTFLFLLLITGGVYPLLTTALGQWWFPWQANGSLIREGDTVRGSALIGQNFTGNGYFHGRPSATAEMPYNPQASGGSNLAVSNPELDKQIAARVAALRAANPDASTNVPVELVTASASGLDNNITPQAAAWQIPRVAKARNLSVEQLTQLIAKYSQQPLVKYIGQPVVNIVELNLALDKLDE
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.