PharMolix/UniProtQA huggingface dataset:
Protein: NLS1_HUMAN
Sequence: MAKGEGAESGSAAGLLPTSILQSTERPAQVKKEPKKKKQQLSVCNKLCYALGGAPYQVTGCALGFFLQIYLLDVAQKDEEVVFCFSSFQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSANHTHGTTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMAPIVLILLGLLLFKMYPIDEERRRQNKKALQALRDEASSSGCSETDSTELASIL
What is the function of this protein?
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828040, PubMed:34135507, PubMed:32572202).  Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity).  Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:34135507, PubMed:26005868).  Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity).  Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity).  Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity).  Not required for central nervous system vascular morphogenesis (By similarity).  Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed:21677192).  In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732, PubMed:23177091).
What are the official names of this protein?
Sodium-dependent lysophosphatidylcholine symporter 1, NLS1, Sodium-dependent LPC symporter 1, Major facilitator superfamily domain-containing protein 2A, HsMFSD2A, MFSD2a.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane (PubMed:21677192).
Protein: RS21_CLOPS
Sequence: MSEIRVKENESLEQALRRFKRQCARAGVLSEVRKREHYEKPSVKRKKKSEAARKRKFK
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: CYB_MYXGL
Sequence: MTKIFRKSDPFIKIVNSALVDLPSPSNISYMWNFGSILGLCLFLQIATGLILTMHFSPSIHMAFSSVVHIVRDVNHGWFIRNFHITGASLFFSCMFIHIGRGIYYGSYKNIKTWYSGVILFICAMVTAFFGYVLPWGQMSFWAATVITNLLSAVPMMGTRMVETVWGGFSVGDPTLKRFLVLHFLVPFLMIAVSLTHLLFLHETGSSNPMGMNPNLDKVPFHPYFSFKDILGFLITLSLIFLGSTLFPYLTTDPDNFTQANSLVTPPHIKPEWYFLFAYAILRAIPNKLMGVFALIMSLSVLLFMPFLIKSNLRSLTFQPFMQFTFWLMISNFILLSWLGAMPLEFPYTIMSQVTSFLYFFIFLFLFPLVSYKENKYLNSRYPPF
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL8_BOVIN
Sequence: MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_CHLCH
Sequence: MPSISTVSKGSIIRFKGEPHSIESLIHRTPGNLRAFYQANMKNLKTGRNVEYRFSSSETVDVIVTERKQYQYLYRDGSDFVMMDNNTFEQINVPEVALGEGANFMKDNINVTIVFSDDGSILQVELPTFVEVEVTDTNPASKDDRATSGTKPAIVETGAEVNVPMFIQIGSVIRVDTRTGEYIERVKK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_SHEB8
Sequence: MNVIDTDDLEKHTPMMRQYLTMKAEHHDMLLFYRMGDFYELFYDDAKRASELLGISLTARGKSGGDPIPMAGLPYHAVEGYLAKLVQIGQSVAICEQIGDPATSKGPVERKVVRIVTPGTLTDEALLQERQDNLLAAVYQGKIGFGYATLDVSSGRFVIAELDTRESLEAELQRTNPVEILYSEDFGELGLLNGFKGKRRRPEWEFDYDTSIKLLLAQFGTKDLHGFGIADARLSLQAAGCLMQYVKDTQRTALPHINAITRFNQTDSIVLDAATRRNLELTQNLAGGRDNTLAAVLDNTATPMGSRMLQRWIHQPLRDPKHIKARQQAVTELLDTAAHEGLHEQLKALGDIERIMARLALRTARPRDFARLRQALGLLPELQQSLSTLSAPHTTQLRQHLGEFPAEQALLERAIVDNPPMLIRDGGVIREGYNSELDEWRGLSEGASDYLVQLEAREKERTGINTLKVGYNRVHGYYIEVSRLQSSQVPLNYQRRQTLKNMERYITPELKEYEEKVLSSQGKALALEKQLWEQLFDFILPKLHELQDFARAAAELDVLSNFAERAETLGYTCPELSQDIGVQIEAGRHPVVERVSQTPFIANPVTLHNQRRMLIVTGPNMGGKSTYMRQVALITLMAHIGCFVPADRALIGPIDRIFTRIGASDDLASGRSTFMVEMTETANILHNATASSLVLMDEIGRGTSTYDGLSLAWSAAEYLAQQVGAMTLFATHYFELTQLPELMAGVYNVHLDAIEHDDTIAFMHAVQEGAASKSYGLQVAALAGVPNKVIKAAKHKLQQLESRDHQAEGTRTPIQSLLALPEPVENPALTKLSSINPDNLTPKQALDLLYELKRLS
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: ZAPB_VIBPA
Sequence: MSFEVLEQLESKIQTAVDTITLLQMEVEELKEDKVKLEAEANELRSQREDLEQKAQQAQQEHAQWQERIRALLGKMDEVE
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: TRUB_MYCPA
Sequence: MSPPGLVVVDKPAGMTSHDVVGRCRRIFATRRVGHAGTLDPMATGVLVLGVERATKILGLLTAAAKSYSATIRLGQATSTDDAEGDVARSVDARHLTSQAIEAAVGGLRGDIHQVPSTVSAIKVAGKRAYKLVREGQAVELPARPVRIDRFEVRGLRAAGACVDVDVEVDCSSGTYVRALARDLGAALGVGGHLTALRRTRVGRFGLEQAYGLDELAECPRLSYSLDEACLLIFGRRDLSADEAEAAGNGRALAAAGIDGVYAACAPDGRVIALLRDEGARTKSVVVLRPATL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: HPR_HALH5
Sequence: MEQQTAYSLKQSIIFSHKFAQLSKALWKSVEKDWQTWIKPFNLNINEHHILWITYHLDGASISDIAKFGVMHVSTAFNFSKKLEERGLLTFSKREHDKRNTYVDLTEQGRELFLETLEAYKPSTYSVYGGALPIKDLYGKFPEFSELLSIVRHVYGPDFIDMFETALTRLEDGFIEEDGKLKAVDSETKSTV
What is the function of this protein?
Negative regulator of protease production and sporulation.
What are the official names of this protein?
HTH-type transcriptional regulator Hpr, Protease production regulatory protein Hpr.
Protein: RBFA_SYNPW
Sequence: MAPGRRVERVAALIRKETSELLMHGIRDDRVHQGLISITQVDVSGDLQHCKIFVSVLADPEGRAQVMEGLQAASSFLRGELGRRLQMRRAPEVVFHLDRGLEKGASVLGLLGDLERERQERGEIPPGSDDAQNCHDDEPS
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OOG3_MOUSE
Sequence: MMICHQCLDQDDSSEEEEAVSVYSPSTLVKLARQRLLREEALVISALKGLPNMLFPVIFEEAFINGHTKILKAMIPMWPFPYLSVGALTNNCNLKTLKAVLDGLDILLAQKVRSSRCKLRVLKWRDEQHDFCGIWPGSHEAEDLPELMTQKHPVQNNPDCGVKKELRVTTELSVMKGRLDDSATYLLEWAQQRKDSIHLLCRKLVIETLTKDTVIEIFKIVNADCIQELELYSLCLEDLAFLNPYLRQMDNLLELTLDHVTDSLSMGDSEMCEEEMITLVSQLPTFPCLQKLCVNDVYFIYGNLNEILRCLKKPLVSFCISNCELSQSDLDCLPYCLNIFELKCLYLIDIPLNHLCLDPLGFLLESVRHTLECLELKSCDMGEPQFNALLPALSQCSHLTDVSFWENELSLLFLKQLLQHTSKLTQLSYELYPAPLECYDDRGLILSHRLEQFCPELLDILRAKRQPKDIAFVTNPCSKCGRYYVYDPKTQRFSLEDTTL
What are the official names of this protein?
Oogenesin-3.
What is the protein family that this protein belongs to?
Belongs to the PRAME family.
Protein: ATP25_PARBP
Sequence: MSRILLRGIQCHACRQNVIRSFVSASGVTITPPAIGSVSPSKAHPPHLSGSFPTRHVKLFSSQAKDDPSLAADAVSENSAAQEGSYPQENSEQHVPWYLQEEVQEMALHPMRQQQELPPLPENPPPILKVLLEYISFDIGLDNLNLLDLRTLDPPPALGANLIMIFGTARSVKHLNVSADKFCRWLRTTYKLRPDADGLLGRNELKIKLRRKARRARLVKRAGSTLKQPDDGITTGWICVDVGIVEGGQLSKPEGVQKAGFVGFGTVIQGTRIVVQMMTEEKREEIDLESLWRQTLEKNSMDNPGLPKPQAEEPPQVVGFTHESSTVTAADFSHRVSQTPPIRANYEQLRSISTSLHRLRDKRGSATDFVPTDTTVATKSAKSISSQESLPSLFNYLSNLEPDKAIDELGQGMDDRTSTSFLQRFYEELARTAPQIASAQKLELMCTGILLQHSGYRKEDLFQAFKEHIVSNYPLPRALVLRLLDALLAFKPDPNSNPPRLRLPGADMELALRLIENAALRGTNILHADFLIRVFLAVSYRTRVYAVKPENLHSAAITGNRIPVSIDEFESVQRIQTRLASIIRAAKVALGEKEYLDILRVHSDQGEYAKFWNAWGEVALAGIHRGKSFYLFLFNLHAELGDWQQSRTTLLNCIPMMWREDPPVFFDAELAEVVSKCIALAYPDIDDTVQHNLPALIVKTWHHCRTAIQNQKMNERKERLIQTELGTLPEN
What is the function of this protein?
Probable mitochondrial mRNA stabilization factor.
What are the official names of this protein?
ATPase synthesis protein 25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATP25 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: DC1L1_HUMAN
Sequence: MAAVGRVGSFGSSPPGLSSTYTGGPLGNEIASGNGGAAAGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVLPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIGILHENFQTLKAEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASPRVPGGSPRTPNRSVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNSLLSKKTGSPGGPGVSGGSPAGGAGGGSSGLPPSTKKSGQKPVLDVHAELDRITRKPVTVSPTTPTSPTEGEAS
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  May play a role in binding dynein to membranous organelles or chromosomes.  Probably involved in the microtubule-dependent transport of pericentrin.  Is required for progress through the spindle assembly checkpoint.  The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.
What are the official names of this protein?
Cytoplasmic dynein 1 light intermediate chain 1, LIC1, Dynein light chain A, DLC-A, Dynein light intermediate chain 1, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the dynein light intermediate chain family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
Protein: MNMA_YERPN
Sequence: MSDNSQKKVIVGMSGGVDSSVSAYLLQQQGYQVAGLFMKNWEEDDDEEYCSAATDLADAQAVCDKLGMELHTVNFAAEYWDNVFELFLAEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRQDVDGKSRLLRGLDGNKDQSYFLYTLSHEQIAQSLFPVGELEKPEVRRIAEQLDLVTAKKKDSTGICFIGERKFRDFLGRYLPAQPGPIMTVDGQLVGKHQGLMYHTLGQRKGLGIGGTKEGGDDPWYVVDKDLDSNTLLVAQGHEHPRLMSVGLVAQQLHWVDRQPVTAPFRCVVKTRYRQQDIPCTVTPLDDERVDVRFDDPVAAVTPGQSAVFYQGEICLGGGIIEQRYPLTNPA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2674_SHEDO
Sequence: MDSLKNHLLIAMPSLDGSFFERTVIYVCEHDEKGAMGIVINRPIGLSVEALLIQMDLDAEANLSDDAQVLIGGPVLPDRGFVLHSPEKVWTNSEAVSDYCTLTTSRDILNAIGSADAPSQFKVALGYSGWSKDQLEQELADNTWLTIKASSELVFDVDYEQLWTLATKELGFDIWQLSSQTGHC
What are the official names of this protein?
UPF0301 protein Sden_2674.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: HSLV_ANAPZ
Sequence: MDHTDDRKMYGTTILSIRRGNSVIVAGDGQVTLGSTIMKTSARKIKRLASNTVITGFAGATADAFTLFERLEGKLEKHPGQLMRACVELAKDWRQDKYLRRLEAMMIVADKSVSLVISGGGDVLEPENGIAAIGSGGNLALAAARALCAAQDEFAPAMPLEYIVAKSMAIAAEICIYTNNNIVMEKIEG
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPB2_THEVB
Sequence: MQPTDPTKFTDKAWEAIVKSQDVAREYRSQYLETEHVMIALLREEGLGQVILERSDIDTEWVLKRLMDFARQQPRVPAGSELYCGRSLDALLDEANRLRQEEEDQFISIEHLLLAFVGDRRIGQRLFRALNCDRQQLAATVKAIRGAQKVLDQNPENKYAALEKYGRDLTEAARQGKLDPVIGRDEEIRRVIQVLSRRTKNNPVLIGEPGVGKTAIAEGLAQRIINGDVPESLKNRRLISLDLGSLVAGAKFRGDFEDRLKAVLHEVTHSEGQIVLFIDELHTVVGAGANQNSSMDASNLLKPMLARGELRCIGATTLDEYRKYIEKDAALERRFQQVYIGQPSVEDTISILRGLKDRYEIHHNVKITDSALVAAAMLSDRYISDRYLPDKAIDLVDEAAAKLKMEITTKPAELEALERRLRQLEMERLSLKQEESLPLSQAPLQATRDRLQRIEAEIAQLQPRQQAMQARWQAEKELLERINSLKEEEDQVKLQIEQAERDYNLNKAAQLKYGRLETLQRELEATEAQLLELQAAGGTFLRDQVTEADIAEIVAKWTGIPLQKLMASERQKLLQLEQVLHQRVIGQSDAVAAVAAAIRRARAGMKDPARPIGSFLFMGPTGVGKTELARALAEALFDDENALVRIDMSEYMEKHAVSRMIGAPPGYVGFDSGGQLTEAIRRRPYAVVLFDEVEKAHPEVFNVLLQVLDDGRITDSQGRTVDFRNTVIIMTSNLGSEHILDLAADDSRYEEMRQRVLQSAQKYFRPEFLNRIDDVILFHGLGRTELAQIAQIQLRRVEKLLADQKIHLRLTPAALDHLVAVGFDPVYGARPLKRAIQRELENPLAVKLLEEVFTPGDTILVDLVGSELTFRAVSPAGTGDRDTVSAS
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB 2.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_LISW6
Sequence: MRVLLQRCYEASVSVEEEVISEIAGGLCLLVGFTHDDTPETVEYMAKKVVGLRIFEDESEKMNISLAERGGAILSVSQFTLYADVSKGKRPSFTKSAPGEKAERLYDLFNTKLSEAGFIVETGVFGAFMDVKIINHGPITMMLDSAEMRK
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KV51_NEMVE
Sequence: MFSARLVLVFAVVLCIQLCNASWLDERAMTQEKRCNGKYQKCTSNSQCCDQKDYAKRKLRCLTQCDEGGCMKYKQCMFYAGTQK
What is the function of this protein?
Neurotoxin that is probably only defensive (Probable).  Acts as a voltage-gated potassium channel (Kv) inhibitor (By similarity).  In vivo, induces a rapid increase in swimming speed on zebrafish larvae, as well as death which occurs between 2 and 18 hours later (PubMed:29424690).
What are the official names of this protein?
Toxin NvePTx1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 5 potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: ENO_SALSV
Sequence: MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVGAVNGPIAQAILGKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKGKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: MDM34_LODEL
Sequence: MSFKVNWNSLETDSLSTWTKEILTNALNSGKSPHILASNISIKDLNFGQSAPDFEILEIGELDRDRFRGIFKISYSGDFHLTLHTKVQANPLNIYYSNSLEKEVGIEDSEFITPQFGLSNEQFAIPLDLKLSDIKISGIGIIVFSKSKGLTLVFRNDPLDSIKVSSTFDTVQVLANFLQKQIESQIRDLFRETLPTLIHQLSLKYLSLDNNMNELRTKLAANASTSSSSTSSTSSSTTSSSSSSSPSSFTSSLDSANTTTSLKMLENEEEDFSLVYSAKNLQKNLKLFKSRETMSLHIPRFRNIVQRTHLDKFTKNYPNLINSLALSNNELQKFTHHPHSHNAVPIDIFKNESFEKTDGLLKDISNIQAGNYYKFATQKENTVKPKRRVIRLGKSKNKSKSKTETKTEHNDENSNNDNQIVPLSSTPASSSSSTLIEEMVEEPSTPIMKETSEFINPATKTTPQTQIHHPTPRKLELRVQADPELHSEVSTDLHSRSSAHHALYQEFIRSTQSPSLYDKVLTTCGGVGLGNTGYFSFVPQRALSASPIKALNEELNEKKSMNHMDFNRVSQRLEEKLKQNNGDMLRKNNSMNSNSNSVDAEDKPQLVHHDTLSATAAAYAGLFTAPPPPYYH
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: GLMU_LEVBA
Sequence: MTTRNTIILAAGKGTRMKSKLYKVLHKVCGKAMVDHVLTQVEKTDMSKIVTVVGYGADEVKSTLGDRTQYALQAEQLGTGHAVLQTEPMLKDEAGTTLIVSGDTPLFRAETFEDLFAYHEAKHAAATILTSMAPDPTGYGRIVRNNIGIVEKIVEQKDANSEEQEIHEINTGVYVFDNQKLFKALHETSNDNAQGEYYLTDVIEILKQQGDIVAAYQMANFDESMGVNDRVALSAATKIMRDRINEAHMRDGVTLIDPATTYIDAGVKIGADTIIEPGVLLKGNTVIGEDCYIGAHSELRNAVLADHVTVTSSLLEDSDMASGSNIGPNSHLRPESHIGPKVHLGNFVEVKKATIGEGTKVGHLTYVGNAKLGRNINVGCGVVFVNYDGKNKHETVVGDDAFIGSNSNLVAPLDVADHSFIAAGSTITDAVNRYDMAIARQRQTNKPNYYQKLPYRGED
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAD_VIBC3
Sequence: MTGRIALLSLTLFSPLSLASTPDGQALDFTHSTIGYAALLIFAIAYTLVMLEEYLQLRKSKPVLLAAGLIWAMIGYVYQQTGSTEVARQALEHNLLEYAELLLFLLVAMTYISAMEERRLFDALKAWMINRGFNFHTLFWITGWLAFFISPIADNLTTALLMCAVVMKVGGENPKFVSLACINIVIAANAGGAFSPFGDITTLMVWQAGHVSFLEFMDLFLPSLANYLVPALVMSLFVPHQTPSSIQEVVELKRGAKRIVVLFLFTILSAIGFHAFFHFPPVIGMMMGLAYLQFFGYFLRKTLARSLAKKTAIAMAKNDEAALKRIGSVVPFDVFRSISHAEWDTLLFFYGVVMCVGGLSLLGYLGLVSEILYTEWNPIWANVLVGLLSSVVDNIPVMFAVLSMQPEMSLGNWLLVTLTAGVGGSLLSIGSAAGVALMGAAHGKYTFLSHLKWTPVILLGYVVSIVLHLLLNHQSFT
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.  Can also transport lithium.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaD, Sodium/proton antiporter NhaD.
What is the protein family that this protein belongs to?
Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SECE_BUCBP
Sequence: MIKATKLKKKYDKLKIAKWSFLGILIILFILSNHYYIKHSNIFQNILLTSLTILSTGLIFLTKSGKKFLIFTKSAIHETKLITWPNFKDTLHVTFTVIIVTILLALILWGLDNILIWFISLITSLRL
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.