PharMolix/UniProtQA huggingface dataset:
Protein: SBCD_STAAE
Sequence: MKIIHTADWHLGKILNGKQLLEDQAYILDMFVEKMKEEEPDIIVIAGDLYDTTYPSKDAIMLLEQAIGKLNLELRIPIIIISGNHDGKERLNYGASWFEHNQLFIRTDFTSINSPIEINGVNFYTLPYATVSEMKHYFEDDTIETHQQGITRCIETIAPEIDEDAVNILISHLTVQGGKTSDSERPLTIGTVESVQKGVFDIFDYVMLGHLHHPFSIEDDKIKYSGSLLQYSFSEAGQAKGYRRVTINDGIINDVFIPLKPLRQLEIISGEYNDVINEKVHVKNKDNYLHFKLKNMSHITDPMMSLKQIYPNTLALTNETFNYNEENNAIEISEKDDMSIIEMFYKHITDKELSDIQSKKIKNILENELRKED
What is the function of this protein?
SbcCD cleaves DNA hairpin structures.  These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions.  The complex acts as a 3'->5' double strand exonuclease that can open hairpins.  It also has a 5' single-strand endonuclease activity (By similarity).  Is involved in the repression of type 5 capsule production by down-regulating cap5 genes via arl-mgr pathway.  Is probably part of the SOS regulon and involved in DNA recombination and repair.
What are the official names of this protein?
Nuclease SbcCD subunit D.
What is the protein family that this protein belongs to?
Belongs to the SbcD family.
Protein: PACA_PELRI
Sequence: MYRKALLVWLLVYGIMRCTVHSSPTALKYPALRLEDEVYDEDGNTLPDFAFDNNPIGIGNPASVFDDMYSFYYPAEKRHADDLLNKAYRNLLGQLSARKYLHTLMAKHLGAVSSSLEDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRIKNKGRRVAYL
What is the function of this protein?
PACAP plays pivotal roles as a neurotransmitter and/or a neuromodulator.  Stimulates adenylate cyclase in pituitary cells.
What are the official names of this protein?
Glucagon family neuropeptides.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: PDXJ_AZOVD
Sequence: MTEANRILLGVNIDHVATLRQARGTRYPDPLKAALDAEEAGADGITVHLREDRRHIQERDVRVLKEVLQTRMNFEMGVTEEMLAFAELIRPAHACFVPETRQELTTEGGLDVAGQEARIRAAVERLARIGCEVSLFIDAEPQQIEAAARIGAPAVELHTGRYADARTPAETARELARIRDGVEYGLSHGLIVNAGHGLHYHNVEPVAAIPGMHELNIGHAIVAHALFVGFKAAVQEMKLLMVGAASRR
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I83A4
Sequence: MNPNQKIITIGSISLGLVVFNVLLHVVSIIVTVLILGKGENNGICNGTVVREYNETVRIERVTQWHNTNVVEYVPYWNGGTYMNNTEAICDVKGFAPFSNDNGIRIGSRGHVFVIREPFVSCSPIECRAFFLTQGSLLNDKHSNGTVKDRSPFRTLMSVEVGQSPNVYQARFEAVAWSATACHDGKKWMTVGVTGPDSKAVAVIHYGGVPTDVVNSWVGDILRTQESSCTCIQGDCYWVMTDGPANRQAQYRIYKANQGRIIGQTDVSFNGGHIEECSCYPNDGKVECVCRDNWTGTNRPVLVISPDLSYRVGYLCAGIPSDTPRGEDAQFTGSCTSPIGNQGYGVKGFGFRQGTDVWMGRTISRTSRSGFEILRIKNGWTQTSKEQVKRQVVVDNLNWSGYSGSFTLPVELSGKDCLVPCFWVEMIRGKPEEKTIWTSSSSIVMCGVDYEVADWSWHDGAILPFDIDKM
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: PSBB_STAPU
Sequence: MALPWYRVHTVVLNDPGRLIAVHLMHTALVSGWAGSMALYELAVFDPSDPILDPMWRQGMFVIPFMTRLGVTKSWGGWSITGETITNAGLWSYEGVAATHIILSGLLFLAAIWHWVYWDLELFRDERTGKPSLDLPKIFGIHLFLSGVLCFGFGAFHVTGLFGPGIWVSDPYGLTGNVQPVIPAWGAEGFDPFNPGGIASHHIAAGILGIIAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFWAAFVVAGTMWYGSAATPVELFGPTRYQWDQGYFQQEIERRIRTSLDEGLSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGAMDNGDGIAVGWLGHAVFKDKEGNELFVRRMPTFFETFPVVLLDKDGVVRADVPFRRAESKYSIEQVGVSVEFYGGELNGVSFSDPATVKKYARRAQLGEIFEFDRATLKSDGVFRSSPRGWFTFGHANFALLFFFGHIWHGSRTLFRDVFSGIDPDLESQVEFGLFQKLGDPTTRKQAV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DMP10_ARATH
Sequence: MEASFIRSLPSAGNFANLLPTGTALIFETLLPSFSNGGECNNKPVNKLLTITLISFCAAACFFSSFTDSYVGQDGRIYYGIATSNGLHILNDYPDEGYDPESGLTADKRERYKLSFVDFVHAFVSVIVFLALAVESSDFRRCLLPEDDENSWGGHFVLMIKYFAVMVLTMASFFFAIFPSKRRGIGISDIR
What is the function of this protein?
Involved in membrane remodeling.
What are the official names of this protein?
Protein DMP10, AtDMP10.
What is the protein family that this protein belongs to?
Belongs to the plant DMP1 protein family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MSCL_BURP6
Sequence: MSIIKEFKEFAVKGNVMDLAIGVIIGGAFSKIVDSVVKDLIMPVIGVLTGGLDFSNKFVLLGQIPASFKGNPESFKDLQAAGVATFGYGSFITVLINFIILAFIIFLMVKFINKLRKPEEAAPAATPEDVLLLREIRDSLKQR
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PI42A_PIG
Sequence: MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSXARSGARFHTSYDRRYVIKTITSEDVAEMHNILKNYHQHIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNXKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKXVKHGAGAEISTVNPEQYSKRFLDFIGHILT
What is the function of this protein?
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).  Has both ATP- and GTP-dependent kinase activities.  May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity).  May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity).  May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity).  May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity).
What are the official names of this protein?
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, PI(5)P 4-kinase type II alpha, PIP4KII-alpha, PtdIns(5)P-4-kinase isoform 2-alpha.
What are the subcellular locations of this protein?
Cell membrane. Nucleus. Lysosome. Cytoplasm. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B (By similarity).
Protein: KDSA_DESAL
Sequence: MTNTFSIGNNMNVGLGAPLLLIAGPCVIENEEKTLEIAERIKGIVRDMDVNFVFKASFDKANRTSIDSFRGPGLEQGLAILGKVKSRLGLPVISDVHSPDQVGPASEVLDILQIPAFLCRQTDLLTAAGNSGKPVNVKKGQFVGPWDMKHVTGKVLSTGNERIMLTERGSSFGYNNLVVDFRNFSIMRDLGFPVVFDATHSVQMPGGLGSCSGGDRSYVPLLARAAAAAGVDGVFFEVHTDPDKALCDGPNSLTMEMLESILPQLLAIRKAAS
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_SHESR
Sequence: MSNEISRNWPAPAKLNLFLHINGRRADGYHELQTLFQFIDCCDLLDFRVTQTPELILHSDMSAVVADSDNLILRAAKSLQQATGYPGGAEIWLEKRLPMGGGLGGGSSDAATTLVALNQLWNTQLSNDELATIGLKLGADIPVFIRGFAAFAEGVGERLQAVTPTEFWYLVIAPDAHVSTAAVFQDPLLPRNTPKLGIDTLMSQPWANDCQDLVVSKYPQVAKALGWLLEYAPSRMTGTGACVFGEFSSQQQALAALAKLPSDMQGFVAKGMNISPLIVRLNHP
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RL36_PSELT
Sequence: MKVRSSVKKRCEHCQVIKRHGRVLIICKANPKHNQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: NDHL_TRIEI
Sequence: MNLDLDTNLIILIIYAALAGAYFLVMPAIVYAYLKTRWYVVSSIERVFMYFLMFLFFPGMLVLSPFLNFRPRKQQIES
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit L, NAD(P)H dehydrogenase I subunit L, NDH-1 subunit L, NDH-L.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhL subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: FOLD_SACD2
Sequence: MSALILDGKALAKKTEDELTQCVDKLKASSGHTPILATILVGDDPASATYVKMKGNACSRIGMESLKVEMPTSTTTEQLLAKINELNANPAVHGILLQHPVPEQIDERACFDAIALEKDVDGVTCLGFGRMAMGEEAYGCATPKGIMRLLEAYNIELNGKHAVVVGRSPILGKPMAAMLLNANATVTICHSRTQNLEAHIKQADIVVGAVGKPEFIKAEWIKDGAVVVDAGYHPGGVGDIELAPLADRAAAITPVPGGVGPMTINTLIYQTVDSAQKKLG
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: IF4E3_MOUSE
Sequence: MALPPAAAPPGANEPLDKALSALPPEPGGVPLHSPWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEIIGVSVSVRDREDVVQVWNVNASLVGEATVLEKIHQLLPHIAFKAVFYKPHEEHHAFEGGRGKH
What is the function of this protein?
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis.  May act as an inhibitor of EIF4E1 activity.
What are the official names of this protein?
Eukaryotic translation initiation factor 4E type 3, eIF-4E type 3, eIF-4E3, eIF4E type 3, eIF4E-3.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
Protein: CUL9_MOUSE
Sequence: MARALRGPGPRSSLDQHVAAVLATVQISSLDTNLQLSGLCALSQAVEEVTERDHPLVRPDRPLREKLVKTLVDLLTNQVGEKMVVVMALRLLYLLMTKHEWRPLFAREGGIYAVLICMQEYKTSVLVQQAGLAALKMLAIANSSDVPTFIPSRDSIQPLFDTQMTREIFASIDSATRPGSESLLLSVPAAVVLMLNTEGCSSAVRNGLLLLNLLLCNHHTLGDQIITQELRDTLFRHSGIAPGTEPMPTTRTILTMLLSRYSEPRGSPERAVLETPSTQGQDGSPESLIRSLVGDLSAELFLDLERVLCHEGSPPAAVRPLLRRLQQETQPFLLLLRTLDAPGPNRTLLLTILRVMTRLLDHPETMVLPWHEVLEPCLNCLNGPSSDSEVVQEVTCFLHRLALMQKDYAVVLCCLGGKEALSKVLDKHSTQLLLASELRHLVAECEKYSQLCSNLTSSILAGCIQMVLGQIEDHRRTYKPITIPFFDVFLRHLCQGSSVEVKEDRCWEKVEVSSNPHRASKLTDRNPKTYWESNGSTGSHSITLHMHRGVLIRQLTLLVASEDSSYMPARVVVFGGDNVGCISTELNTVNVMPSASRVTLLENLTRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTIRAQAWSRDIAEDRQRLLQLYPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSPDAGGVSSLGWLLDQYLEHRESTRSRQGPAASFASQVRRLCHLLVHVEAPPGPSPEPSSQPLSKNSKGQDGSPTPAPTPVCPSTSLRNLTQCWLSVVQGQVSRFLAAAWRASDFVPRYCSLYQRLQSAGSELFGPRAAFTLALRSGFSGALLQQSFLTAAHISEQFARHIDQQIHGGLLGGAAGVGMLGRLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSLGSSWLEGAVLEQIGPCFPNRLPQLMLQSLHTSEELQHRFHLFQLQQLDRQLLEQGDQEEWRPEKVEEDDEGQETGRELFTDPGPAISVLVLSPRCWPVSPLCYLHHPRKHLQAELCDALERFSSFYSHSQNCPVLDIGPHRRLQWTWLGRAELQLGDQTLHVSLNTVQMWLLFNQSEEVSVETLLRNSDLSPELLHQALLPLTSDNGPLTLEETQDYPQGGVLRLREPRSQTHEEFLWLIPPQTYLSVEKDEGRTLEQKRNLLSCLLVRILKAHREKGLHIDQLVCLVLEAWQKGPDPPGRLGNAAAVGVACSSTDVLSCILHLLGQGYVERRDDRPQVLMYATPEPMGPCRGQADVPFCGNKNTETSRPSPEAVVALASLQLPAGRTMSPQEVEGLMEQTVRQVQETLNLEPDVAQHLLAHSHWGTEQLLQSYSDDPEPLLLAAGLRVPQAQVVPTRPDQCPVCVTPLGPHDDSPSLCCLHCCCKSCWNEYLTTRIEQNFVLNCTCPIADCPAQPTGAFIRNIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGSGTTCSKCGWASCFSCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCARCNHGFCWRCLKSWKPSHKDYYNCSAMVSKAARQEKRFQDYNERCTFHHQAREFAVNLRNQASAIQEVPPPKSFTFLQDACRALEQARKVLAYACVYSFYSQDTEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRFLRADCLSTGTELLRRIQERLLAILQHSTQDFRVGLQSPSVETREVKGSNVPSDQPQGSSGLEVEDEEEEEEEEEEEEEEEEEDVPEWQHEFDEELDNDSFSYDEESENLDRETFFFGDEDEDDESYD
What is the function of this protein?
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity.  Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696).  Cytoplasmic anchor protein in p53/TP53-associated protein complex.  Regulates the subcellular localization of p53/TP53 and subsequent function.
What are the official names of this protein?
Cullin-9, CUL-9, p53-associated parkin-like cytoplasmic protein.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACD_STAA9
Sequence: MSKSNQKIASIEQLSNNEGIISALAFDQRGALKRMMAKHQTEEPTVAQIEQLKVLVAEELTQYASSILLDPEYGLPASDARNKDCGLLLAYEKTGYDVNAKGRLPDCLVEWSAKRLKEQGANAVKFLLYYDVDDAEEINIQKKAYIERIGSECVAEDIPFFLEVLTYDDNIPDNGSVEFAKVKPRKVNEAMKLFSEPRFNVDVLKVEVPVNMKYVEGFAEGEVVYTKEEAAQHFKDQDAATHLPYIYLSAGVSAELFQETLKFAHEAGAKFNGVLCGRATWSGAVQVYIEQGEDAAREWLRTTGFKNIDDLNKVLKDTATSWKQRK
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase, D-tagatose-1,6-bisphosphate aldolase, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: CAMT4_TOBAC
Sequence: MATDGENGRHQEVGHKSLLQSDALYQYILETSVYPREPEPMKELREITAKHPWNLMTTSADEGQFLSMLIKLINAKNTMEIGVFTGYSLLATAMALPDDGKILAMDINRENYEIGLPVIEKAGLAHKIEFKEGPALPVLDQMIEDGKYHGSYDFIFVDADKDNYLNYHKRLIDLVKIGGLIGYDNTLWNGSVVAPPDAPLRKYVRYYRDFVLELNKALAADSRIEICQLPVGDGITLCRRIS
What is the function of this protein?
Methylates caffeoyl-CoA to feruloyl-CoA and 5-hydroxyferuloyl-CoA to sinapoyl-CoA.  Plays a role in the synthesis of feruloylated polysaccharides.  Involved in the reinforcement of the plant cell wall.  Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers.
What are the official names of this protein?
Caffeoyl-CoA O-methyltransferase 4, Trans-caffeoyl-CoA 3-O-methyltransferase 4, CCoAMT-4, CCoAOMT-4.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.
Protein: Y3787_MYCA9
Sequence: MARTDDDSWDLASSVGATATMVAAQRALASHVPNPLINDPYAEPLVRAVGIEYFTKLASGAFDPEQMAGLVQLGITADGMANGMASRTWYYDTAFESSTAAGVRQAVILASGLDTRAYRLTWPAGTTVYELDQPEVITFKTDTLAELGASPSAERRTVAIDLREDWPAALQAAGFDPEQPTVWSAEGLLIYLPPEAQDRLFASITELSAPGSRLVCEQVPGLETADFSKARELTRQFAGETLDLDLESLVYTQERQMAADWLAEHGWTVITEENDELYARLNLDPPNPLLRSIFPNIVYVDATLG
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAB_3787.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: RN111_XENTR
Sequence: MKSEVSSDAPKRQENLKGVLLNPEAIGASKSFPKEVEMIASKVSNEFSHLCSDTNKQQRDLNSNGTEQEKNLVVHKKRKNQQAGTSYAQSCEVKENQRLLRLQPQSDEDNDSSFSDCISSPSSSSHFGDSDTMTSDEDKDNPRRYSPAGVNATPRTQSARAQKWPRPHTDSVSSLVMKRPCYQVSSLRRPLHRKRFVKNVSSQRTQKQKERMMLQRKKREVLARQKYALLPSSSSSSENDLSSESSSSSSTEGEEDLFVSPGENHQDGTTLPSGGMDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGETYRSRTTLGHPRSHWGQNTQSGRTQEQRTRNRVSTVIQPLRQNTTEVVDLTVDEDDPTVVPTTSGRVESQPVSTVSSNTSTSEPASDSASGPLGSRGSAIPEIPPIPPNSNTVGTIADDSRTSTSGTNVDGGPPAMPRLPSCCPQHSPCGGSSQNHVLGHPHSSCFPPHSHHFPHHHHHHHQSSHPGVPLSPSFRDSHCPVERNAAVPPPCGATSSSGSTYHDPQALPVDLSNNGIRSHGSVSFHSTSAFDPCCPGSSSRSTVYGHQSTTSTAQTMAIDGYGSSMVAQAQPPPPTPLSSCRHYMHAPYTSLTRPLHHQTSSCPHSHSNVGDYVIAHQVPFISPLPSLAATHAVPPPPPSHHLSTAAAPQHLSTSHQSMSHHISATAPATQRLHTHEVIQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQGPERSAWEIAIETGVTAAPYQTGPLHTHLAHYHAPPRLHHLQIGALPLMVPDMAGYPHIRYISSGLDGRSFRVPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYEKVSTDWFSQRKLHSKQDGEEATEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIDTQLPTES
What is the function of this protein?
E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity).  Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP.  Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP.  Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity).  The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase arkadia, RING finger protein 111, RING-type E3 ubiquitin transferase arkadia.
What is the protein family that this protein belongs to?
Belongs to the Arkadia family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, PML body. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.
Protein: PPR53_ARATH
Sequence: MTKQVLPLIEKIPQSIVGFLESSSYHWSSSLSKTTQAHARILKSGAQNDGYISAKLIASYSNYNCFNDADLVLQSIPDPTIYSFSSLIYALTKAKLFTQSIGVFSRMFSHGLIPDSHVLPNLFKVCAELSAFKVGKQIHCVSCVSGLDMDAFVQGSMFHMYMRCGRMGDARKVFDRMSDKDVVTCSALLCAYARKGCLEEVVRILSEMESSGIEANIVSWNGILSGFNRSGYHKEAVVMFQKIHHLGFCPDQVTVSSVLPSVGDSEMLNMGRLIHGYVIKQGLLKDKCVISAMIDMYGKSGHVYGIISLFNQFEMMEAGVCNAYITGLSRNGLVDKALEMFELFKEQTMELNVVSWTSIIAGCAQNGKDIEALELFREMQVAGVKPNHVTIPSMLPACGNIAALGHGRSTHGFAVRVHLLDNVHVGSALIDMYAKCGRINLSQIVFNMMPTKNLVCWNSLMNGFSMHGKAKEVMSIFESLMRTRLKPDFISFTSLLSACGQVGLTDEGWKYFKMMSEEYGIKPRLEHYSCMVNLLGRAGKLQEAYDLIKEMPFEPDSCVWGALLNSCRLQNNVDLAEIAAEKLFHLEPENPGTYVLLSNIYAAKGMWTEVDSIRNKMESLGLKKNPGCSWIQVKNRVYTLLAGDKSHPQIDQITEKMDEISKEMRKSGHRPNLDFALHDVEEQEQEQMLWGHSEKLAVVFGLLNTPDGTPLQVIKNLRICGDCHAVIKFISSYAGREIFIRDTNRFHHFKDGICSCGDFW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g20230.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
Protein: SYDND_RHOPT
Sequence: MHRYRTHTCGALRDSHIDQTVRLSGWCHRIRDHGGVLFIDLRDHYGLTQCVADPDSPAFKDAEKLRAEWVVRIDGKVRRRPEGTDNPDLPTGAVEVFVTEIEVLGPAGELPLPVFGEQEYPEDVRLRYRFLDLRREKLHQNIMTRGAIVDSMRRRMKEQGFFEFQTPILTASSPEGARDFLVPSRIHPGKFYALPQAPQQYKQLLMMSGFDRYFQIAPCFRDEDPRADRLPGEFYQLDVEMSFVTQDDIFAAMEPVITGVFEEFAKGKRVTKGWPRIAFADSMRKYGTDKPDLRNPIEMQDVSEHFRGSGFKVFARMLEEQRNQVWAIPGPGGGSRAFCDRMNSWAQGEGQPGLGYIMWREGGEGAGPLANNIGPERTEAIRTALGLKAGDAAFFVAGDPSKFVKFAGLARTKVGEELNLIDKDQFALAWVVDFPMYEYNEDDKKVDFSHNPFSMPQGGMEALTSQDPLTIKAFQYDITCNGYEIASGGIRNHRPEAMVKAFEIAGYGEQEVVDRFGGMYRAFQYGAPPHGGMAAGVDRIVMLLCGTTNLREISLFPMNQRAEDLLMGAPSEVSPKQLRELHIRLNLPDTK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUS1A_XENLA
Sequence: MVNMETCAMDCCVLKALLAERAHKCLILDCRSFFSFSSCSIVGSSNVRLSTIVKRRAKGSMGLEHIVPNEEQRCRLVAGMYEAVVLLDERTSELDMLRKDSTMMLAVNALCRDSRGSSIYFLKGGYETFSAQCPEFCTKNSPPVGLSLPLCANNVPGSADSNCTPCGTPLYDQGGPVEILPFLYLGSAYHASRKDMLDTLGITALINVSANCPNHFEGHFQYKSIPVEDSHKADISSWFNEAIDFIDSVKNSGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPSCSAEAGSPTISVLDRGTSTTTVFNFPVSIPVHSGANSLSYLQNPITTSPSC
What is the function of this protein?
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-188' and 'Tyr-190', regulating its activity during the meiotic cell cycle.
What are the official names of this protein?
Dual specificity protein phosphatase 1-A, XCL100, XCL100-alfa.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL16_BARHE
Sequence: MLQPKRTRFRKQFKGRIHGVSKGGTDLNFGAYGLKAVEPERITARQIEAARRAITRYMKRSGRVWIRIFPDLPVTSKPTEVRMGKGKGSVDYWAARVAPGRIMFELDGIPEDVAREALRLGAAKLPIKTRFIQRIAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.