PharMolix/UniProtQA huggingface dataset:
Protein: DEF_FINM2
Sequence: MALRQIRLENDPILRKKSREVEKIDDRIKQIVEDMFETMYENKGIGLACVQVGMLKRIVVIDMQDEDGKMVLINPKIIEKSEEKQINIEGCLSVPGKNGYVERPKTVVVEYTDLNGNTQRVMGTDYKAHCFCHELDHLDGVLYTDKVLNLSEEEVERLNNEK
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: LUXS_GEOKA
Sequence: MPSPVESFELDHCAVKAPYVRHCGVHKVGSDGVVNKFDIRFCQPNKEAMDPAAIHTLEHLLAYTLRRHAAKYDHFDIIDISPMGCQTGFYLVVSGSPTVDEIIDLLEEAMKDALAATEVPAATERQCGQAKLHDLEAAKQLMRFWLSQEKEELKKVFG
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: GPMB_KLEP7
Sequence: MLQVYLVRHGETQWNAERRIQGQSDSPLTAHGERQAWQVGERARTLGITHIITSDLGRTRRTAEIIAEACGCSVIADARLRELDMGVLEKRHIDSLSEEEEGWRRQLVNGTPDGRIPQGESMQELSERMHAALASCLELPAGSRPLLVSHGIALGCLVSTILGLPAYAERRLRLRNCSISRVDYQQSPWLASGWVVETAGDVSHLDAPAMDELQR
What are the official names of this protein?
Probable phosphoglycerate mutase GpmB, PGAM, Phosphoglyceromutase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. GpmB subfamily.
Protein: RS15_PERMH
Sequence: MSITPEKKAEIIKRFARHEGDTGSPEVQIAILTERIKNLTEHIKKNKKDLHSRRGLIGMVNKRRKLLNYLKRTDFERYQKIIQELNIREATGSR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: GREA_THEPX
Sequence: MSKPVILTYEGLKKLEEELEYLKTVKRAEVAEKIKQARAFGDLSENSEYDEAKNEQAFIEGRIATLEAMLKNAKVIDEEDIKLDQVSIGCTVKVYDESYNEEVEYTIVGSAEADPMNNKISDESPIGKALLGKKVGDVVSVEVPAGIIKLKILEIRK
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: AROC_STRPS
Sequence: MRYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYGRGGRMKIESDQVVFTSGVRHGKTTGAPITMDVINKDHQKWLDIMSAEDIEDRLKSKRKITHPRPGHADLVGGIKYRFDDLRNSLERSSARETTMRVAVGAVAKRLLAELDMEIANHVVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQIKRDGDTIGGVVETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGVEFGLGFEAGYRKGSQVMDEILWSKEDGYTRRTNNLGGFEGGMTNGQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKATVERSDPTALPAAGMVMEAVVATVLAQEILEKFSSDNLEELKEAVAKHRDYTKNY
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: FPG_GLUOX
Sequence: MPELPEVETVMRGFRDAFEGHRISHVTVNRPDLRWPFPADLREKLEGHHVLSFRRRAKYILVRLEGGWSMLLHLGMSGRLTIGRAGTNATPPAHEHLVLETDSGARAGLVDPRRFGMVDLVRTSEEDSHRLLAHLGMEPLSDAMTGPALAELFRGRRSPIKSALLDQKLIAGLGNIYVCEALFRCGIHPERQACTLTGEETAALAEAIPQILEQAIASGGSSLRDYVQADGTKGAFQDLHLVYGREGVPCPNCGAEHPIQRITQAGRSTFFCPTCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: SFSA_PSESM
Sequence: MRFSPELEQGRLLVRYKRFLADIETDSGELLTIHCPNTGSMLNCMMPGGRVWFSRSNDPKRKLPGTWEISETPQGRLACINTGRANTLVEEALRAGVIRELEGFTALKREVAYGQEKSRVDFRLEYPDGYLYLEVKSVTLGFADSAVAAFPDAVTQRGARHLRELATLAREGVRAVLLYCVNLTGIEAVRPAKEIDPAYAAALREAVDAGVQILAYGVQLTPEAVYIDRHLEVHWPD
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: CDH_MYCTO
Sequence: MPKSRRAVSLSVLIGAVIAALAGALIAVTVPARPNRPEADREALWKIVHDRCEFGYRRTGAYAPCTFVDEQSGTALYKADFDPYQFLLIPLARITGIEDPALRESAGRNYLYDAWAARFLVTARLNNSLPESDVVLTINPKNARTQDQLHIHISCSSPTTSAALRNVDTSEYVGWKQLPIDLGGRRFQGLAVDTKAFESRNLFRDIYLKVTADGKKMENASIAVANVAQDQFLLLLAEGTEDQPVAAETLQDHDCSITKS
What are the official names of this protein?
Probable CDP-diacylglycerol pyrophosphatase, CDP-diacylglycerol phosphatidylhydrolase, CDP-diglyceride hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Cdh family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: FMT_SHESW
Sequence: MKSLNIIFAGTPDFAARHLQALLNSQHNVIGVYTQPDRPAGRGKKLTASPVKELAVANNIPVYQPGSLRKEPAQQALAALNADIMVVVAYGLILPKVVLDTPRLGCINVHGSILPRWRGAAPIQRALWAGDKETGVTVMQMDVGLDTGDMLLKTYLPIEDSDTSASLYEKLAEQGPVALLQALKGLANGTLAAEKQDEALANYAEKLSKEEARLDWNKSAKQLWQEVRAFNPWPVSYFEHQGNTIKVWQAHVSETISTAAPGTIISASKRGIEVATADGVLTLLSMQLPGKKPLNVADILNARGEWFSPNTRLANEAE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: PYRG_PROM9
Sequence: MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTDTAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITREIRERIHRVASNSNADIIITEIGGTVGDIESLPFLEAIREFKNDVNRNDVAYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKSINEGLKKKLSGFCGVNINSVIEALDADSIYSVPLSLKKEGLCKETLKYLELEDKECDLKNWEKLVHNLRNPGTPIKVALVGKYIELGDAYLSVVEALRHACIEQKALLDLHWVSAEMIEKDSAETYLNEVDAIVVPGGFGNRGVNGKISAIKFARENKIPFLGLCLGMQCAVIEWARNVANLPDASSSELDPKTPNPVIHLLPEQEDVVDLGGTMRLGVYPCRLTNNTIGKKLYDEDVIYERHRHRYEFNNYYKQSFLNSGYKISGTSPDGRLVELIELDNHPYFLACQYHPEFLSRPGKPHPLFKGLIKSSQENLTQSN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: RL3_BACVZ
Sequence: MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAENDGYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVDMDAYEIGQEVKVEIFSAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLLPGRMGGDQITVQNLEIVKVDAERNLLLIKGNVPGARKTLITVKSAVKSK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ODC_MOUSE
Sequence: MSASNVSLLHETSRQVAAGGSAGLVEICLMHPLDVVKTRFQVQRSVTDPQSYRTVRGSFQMIFRTEGLFGFYKGIIPPILAETPKRAVKFSTFELYKKFLGYMSLSPGLTFLIAGLGSGLTEAVVVNPFEVVKVGLQVNRNLFKEQPSTFAYARQIIKKEGLGFQGLNKGLTATLGRHGIFNMVYFGFYHNVKNIIPSSKDPTLEFLRKFGIGFVSGTMGSVFNIPFDVAKSRIQGPQPVPGEIKYRSCFKTMEMIYREEGILALYKGLVPKVMRLGPGGGVMLLVYEYTYAWLQENW
What is the function of this protein?
Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism.  Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate.  Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.
What are the official names of this protein?
Mitochondrial 2-oxodicarboxylate carrier, Solute carrier family 25 member 21.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NCAP_CVHNL
Sequence: MASVNWADDRAARKKFPPPSFYMPLLVSSDKAPYRVIPRNLVPIGKGNKDEQIGYWNVQERWRMRRGQRVDLPPKVHFYYLGTGPHKDLKFRQRSDGVVWVAKEGAKTVNTSLGNRKRNQKPLEPKFSIALPPELSVVEFEDRSNNSSRASSRSSTRNNSRDSSRSTSRQQSRTRSDSNQSSSDLVAAVTLALKNLGFDNQSKSPSSSGTSTPKKPNKPLSQPRADKPSQLKKPRWKRVPTREENVIQCFGPRDFNHNMGDSDLVQNGVDAKGFPQLAELIPNQAALFFDSEVSTDEVGDNVQITYTYKMLVAKDNKNLPKFIEQISAFTKPSSIKEMQSQSSHVAQNTVLNASIPESKPLADDDSAIIEIVNEVLH
What is the function of this protein?
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M.  Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the alphacoronavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Protein: XYNA_RUMFL
Sequence: MKLSKIKKVLSGTVSALMIASAAPVVASAADQQTRGNVGGYDYEMWNQNGQGQASMNPGAGSFTCSWSNIENFLARMGKNYDSQKKNYKAFGNIVLTYDVEYTPRGNSYMCVYGWTRNPLMEYYIVEGWGDWRPPGNDGEVKGTVSANGNTYDIRKTMRYNQPSLDGTATFPQYWSVRQTSGSANNQTNYMKGTIDVTKHFDAWSAAGLDMSGTLYEVSLNIEGYRSNGSANVKSVSVTQGGSSDNGGQQQNNDWNQQNNNQQQNNDWNNWGQQNNDWNQWNNQGQQNNDWNNWGQQNNDWNQWNNQGQQQNNDWNNWGQQNNDWNQWNNQGQQQNNDWNNWGQQNNDWNQWNNQGQQQNNDWNNWGQQNNDWNQWNNQNNNQQNAWNGWDNNNNWNQNNQQQNNWDWNNQNNWNNNQQQNNDWNQWNNQNNWNNNQQQNNDWNQWNNQGQQNNDWNQWNNQNNWNQNNNQQNAWNGWDNNNNWNQWDQNNQWNNQQQNNTWDWNNQNNWNNNQQNNDWNQWNNQGQQQNNDWNQWNNQNNNQNNGWDWNNQNNWNQNNNQQNAWNGWDNNNNWNQWGGQNNDWNNQQQNNDWNQWNNQGQQQNNDWNNQNNWNQGQQNNNNSAGSSDSLKGAFSKYFKIGTSVSPHELNSGADFLKKHYNSITPENELKPESILDQGACQQKGNNVNTQISLSRAAQTLKFCEQNGIALRGHTFVWYSQTPDWFFRENFSQNGAYVSKDIMNQRLESMIKNTFAALKSQYPNLDVYSYDVCNELFLNNGGGMRGADNSNWVKIYGDDSFVINAFKYARQYAPAGCKLYLNDYNEYIPAKTNDIYNMAMKLKQLGYIDGIGMQSHLATNYPDANTYETALKKFLSTGLEVQITELDITCTNSAEQADLYEKIFKLAMQNSAQIPAVTIWGTQDTVSWRSSQNPLLFSAGYQPKPAYDRVMALAK
What is the function of this protein?
Xylanase domain releases more xylo-oligosaccharides and GH10 domain more xylose.
What are the official names of this protein?
Bifunctional endo-1,4-beta-xylanase XylA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glycosyl hydrolase 10 (cellulase F) family.
Protein: ARGJ_SORBI
Sequence: MPPPSLLHLHSRAPLQPRPFRMNSRAAPSRVVVCSVASAEGFISAAPILLPDGPWKQVEGGVTAAKGFKAAGIYGGLRAKGEKPDLALVTCDVDATVAGTFTTNVVAAAPVLYCKHALSTSKTGRAVLINAGQANAATGDLGYQDAVDSADAVAKLLNVSTDNILIQSTGVIGQRIKKEALLNSLPRLVGSLSSSVQGANSAAVAITTTDLVSKSIAVQTEIGGVAIRIGGMAKGSGMIHPNMATMLGVLTTDAQVSNDVWREMVRTSVSRSFNQITVDGDTSTNDCVIAMASGLSGLSRIQSLDSIEAQQFQACLDAVMQGLAKSIAWDGEGATCLIEVTVSGANNEAEAAKIARSVASSSLVKAAVFGRDPNWGRIACSVGYSGIQFDANRLDISLGVIPLMKNGQPLPFDRSAASRYLKDAGDAHGTVNIDISVGSGGGNGKAWGCDLSYKYVEINAEYTT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PANG2_DROME
Sequence: MPHCGTTNSEINLNSNELISYQKKKSNEDLQKKHDKKCSINLKTSQVPDGGFNNQYTQLTANKIEQYNCNDLDKVCIVPSSRSDGMEASFSELLLSPNKLISQPWQTAEEIENWQNDSFRQRNEMFSCIYTNSMLNQQPCSQQQLLATQLLYARLLRSQLAEREFHSNKFNMVHYSGSKKTMLREDELLSTPSSQDNNNNIKLIKDIENSISCVDPPLFEFSNVHQRAEQKNKQDDKNCYSPKLKSNKEALDGYDLQHTCDFIREQKNILIDIKKKLDNLSDSSGKFRKRLSVRQSHIEVNNGSNSALEESVRRQLNGNRKSIENLLEEVKRLYNQWSSAELYYVRSLQRLGLPSEEDGEYTSTPTHTIMALAAIALSNESILPQKTNAVHSKIPDVESESDFFLTSAKPKTLVEIEDIILQLASSVNMHQSSSASTPHESYSDSVKSDCEESNSAPTCIWHSTRQTFRHKKDVEPCSTAAEIILEYASLSSSSNIETSRLLTSASNLTDVTENYNVTTQLPIVFNYNRESSAESIVTDPLLVPEFSTAPSTPSTGSNSGCSTGMVSGIFGLSQNRRKQRLARHIETLTTNSFKSNAIRGNVDNEITNQLKTSPSIRALPTENVSHLITKTLSSANASLTAQELSITNLFKERLCALQGNAGSMKTEIFPMIDAPYDLSIGSKTKHMNLEAKHTSNAQSNESKETTNDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHELSREEQSKYYEKARQERQLHMELYPGWSARDNYGYVSKKKKRKKDRSTTDSGGNNMKKCRARFGLDQQSQWCKPCRRKKKCIRYMEALNGNGPAEDGSCFDEHGSQLSDDDEDDYDDDKLGGSCGSADETNKIEDEDSESLNQSMPSPGCLSGLSSLQSPSTTMSLASPLNMNANSATNVIFPASSNALLIVGADQPTAQQRPTLVSTSGSSSGSTSSISTTPNTSSTVSPVTCMTGPCLGSSQERAMMLGNRFSHLGMGLSPPVVSTSTSKSEPFFKPHPTVCNNPIFALPSIGNCSLNISSMPNTSRNPIGANPRDINNPLSINQLTKRREYKNVELIEASESKTIVAHAATSIIQHVAVNGYHANHSLLNSNLGHLHHQLNNRTENPNRSEQTMLSVSNHSVNSSECHKESDSQAIVSSNPPNAGSSDNGVISVS
What is the function of this protein?
Segment polarity protein.  Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues.  Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.
What are the official names of this protein?
Protein pangolin, isoform J, dTCF.
What is the protein family that this protein belongs to?
Belongs to the TCF/LEF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COMQ_BACSU
Sequence: MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGENLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSIYSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGVLLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDASEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLDKEKKELIKECLLSYTKGDTRCKT
What is the function of this protein?
Part of a major quorum-sensing system that regulates the development of genetic competence (PubMed:1715859, PubMed:11751817).  Involved in the maturation of the competence pheromone ComX (PubMed:11751817, PubMed:31670609).  Acts by catalyzing the transfer of a farnesyl group on the ComX pheromone (PubMed:31670609).  Shows weak geranylation activity with geranyl diphosphate (GPP) (PubMed:31670609).
What are the official names of this protein?
Tryptophan prenyltransferase ComQ, Competence regulatory protein ComQ.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: XTH3_ARATH
Sequence: MDYMRIFSVFVVTLWIIRVDARVFGGRGIEKFVTFGQNYIVTWGQSHVSTLHSGEEVDLYMDQSSGGGFESKDAYGSGLFEMRIKVPSGNTGGIVTAFYLTSKGGGHDEIDFEFLGNNNGKPVTLQTNLFLNGEGNREERFLLWFNPTKHYHTYGLLWNPYQIVFYVDNIPIRVYKNENGVSYPSKPMQVEASLWNGDDWATDGGRTKVNWSYSPFIAHFRDFALSGCNIDGRSNNVGACESSNYWWNAGNYQRLSGNEQKLYEHVRSKYMNYDYCTDRSKYQTPPRECY
What is the function of this protein?
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET).  Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity).
What are the official names of this protein?
Xyloglucan endotransglucosylase/hydrolase protein 3, At-XTH3, XTH-3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted, extracellular space, apoplast.
Protein: RL22_MARMS
Sequence: MSEVKASLKGARLSAQKARLVVDQIRGKSVSEALNILTFSPKKAAVIVKKVLESAIANAEHNEGADVDDLRVSTAYVDEAMTLKRIMPRAKGRADRILKRGCHITVKVAD
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: LEPA_HYPNA
Sequence: MRPMTPRDKIRNFSIIAHIDHGKSTLADRLIQACGGLTDREMSEQVLDSMDIEKERGITIKAQTVRLSYTASDGETYTLNLMDTPGHVDFAYEVSRCLAACEGSLLVVDASQGVEAQTLANVYQAIDQNHEIVPVLNKIDLPAADVDRVKEQIEEIIGLDASDAVQISAKTGLGIPDVLEAIVNRLPPPRGGDHTAPLKAALVDAYYDPYLGVVVIVRVHEGILKKKQTIRMMRTGGVYEIDKVGTFNPKLTEADALGPGEVGYFVASIKEVGDCSIGDTITEDKRPTDKALPGYKDVQPVVFCGLFPMDAGDFDDLRAAMGKLRLNDASFTWEMETSAALGMGFRCGFLGLLHLEIIQERLSREFDLDLIATAPSVVYEMSMTDGTEIELHNPADMPDVVRITEIREPWIAATIYTPDEYLGSILKLCQDRRGIQIELSYVGGRACVKYELPLNEVVFDFYDRLKSISRGYASFDYTLIGHRAENLVKLQILVNEEPVDALAMLVHRDRAESRGRQMCERLKELIPRQMFKIPIQAAIGGRVVARETISAMRKDVTAKCYGGDATRKRKLLDKQAAGKKRMRQFGKVEIPQEAFVAALRMDGD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: THI3_YEAST
Sequence: MNSSYTQRYALPKCIAISDYLFHRLNQLNIHTIFGLSGEFSMPLLDKLYNIPNLRWAGNSNELNAAYAADGYSRLKGLGCLITTFGVGELSAINGVAGSYAEHVGILHIVGMPPTSAQTKQLLLHHTLGNGDFTVFHRIASDVACYTTLIIDSELCADEVDKCIKKAWIEQRPVYMGMPVNQVNLPIESARLNTPLDLQLHKNDPDVEKEVISRILSFIYKSQNPAIIVDACTSRQNLIEETKELCNRLKFPVFVTPMGKGTVNETDPQFGGVFTGSISAPEVREVVDFADFIIVIGCMLSEFSTSTFHFQYKTKNCALLYSTSVKLKNATYPDLSIKLLLQKILANLDESKLSYQPSEQPSMMVPRPYPAGNVLLRQEWVWNEISHWFQPGDIIITETGASAFGVNQTRFPVNTLGISQALWGSVGYTMGACLGAEFAVQEINKDKFPATKHRVILFMGDGAFQLTVQELSTIVKWGLTPYIFVMNNQGYSVDRFLHHRSDASYYDIQPWNYLGLLRVFGCTNYETKKIITVGEFRSMISDPNFATNDKIRMIEIMLPPRDVPQALLDRWVVEKEQSKQVQEENENSSAVNTPTPEFQPLLKKNQVGY
What is the function of this protein?
One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) involved in amino acid catabolism.  The enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids (alpha-keto-acids).  In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols.  Its preferred substrates are the transaminated amino acids derived from leucine (4-methyl-2-oxopentanoate, also alpha-keto-isocaproate) and isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), whereas transaminated valine, transaminated aromatic amino acids, and pyruvate are no substrates.  In analogy to the pyruvate decarboxylases the enzyme may in a side-reaction catalyze condensation (or carboligation) reactions leading to the formation of 2-hydroxy ketone, collectively called acyloins.  The enzyme is also positively regulating the thiamine metabolism by a molecular mechanism that may involve thiamine concentration sensing and signal transmission.
What are the official names of this protein?
Thiamine metabolism regulatory protein THI3, Keto isocaproate decarboxylase 1, Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase, 2ODC.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS5_MYCTU
Sequence: MTAKSVVVLDYGSGNLRSAQRALQRVGAEVEVTADTDAAMTADGLVVPGVGAFAACMAGLRKISGERIIAERVAAGRPVLGVCVGMQILFACGVEFGVQTPGCGHWPGAVIRLEAPVIPHMGWNVVDSAAGSALFKGLDVDARFYFVHSYAAQRWEGSPDALLTWATYRAPFLAAVEDGALAATQFHPEKSGDAGAAVLSSWVDGL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.