PharMolix/UniProtQA huggingface dataset:
Protein: ISPF_YERPS
Sequence: MRIGHGFDVHKFGENGSGPLIIGGVRIPYEKGLLAHSDGDVALHAATDALLGAAALGDIGKLFPDTDPAFKGADSRGLLREAYRRILAKGYKLGNLDITIIAQAPKMAPHIPQMRVNLAEDLQCHMDDINVKATTTEQLGFTGRGEGIACEAVVLLVNVEQG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: WFS1_HUMAN
Sequence: MDSNTAPLGPSCPQPPPAPQPQARSRLNATASLEQERSERPRAPGPQAGPGPGVRDAAAPAEPQAQHTRSRERADGTGPTKGDMEIPFEEVLERAKAGDPKAQTEVGKHYLQLAGDTDEELNSCTAVDWLVLAAKQGRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVAELLENVGQVNEHDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVEITKKYAKGVIPSSLFLQDDEDDDELAGKSPEDLPLRLKVVKYPLHAIMEIKEYLIDMASRAGMHWLSTIIPTHHINALIFFFIVSNLTIDFFAFFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYAHFLLSVFFVIFSFPIASKDCIPCSELAVITGFFTVTSYLSLSTHAEPYTRRALATEVTAGLLSLLPSMPLNWPYLKVLGQTFITVPVGHLVVLNVSVPCLLYVYLLYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLESTGLGLLRASIGYFLFLFALPILVAGLALVGVLQFARWFTSLELTKIAVTVAVCSVPLLLRWWTKASFSVVGMVKSLTRSSMVKLILVWLTAIVLFCWFYVYRSEGMKVYNSTLTWQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAINMLPFFIGDWMRCLYGEAYPACSPGNTSTAEEELCRLKLLAKHPCHIKKFDRYKFEITVGMPFSSGADGSRSREEDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMAQLSPTRRHVKIEHDWRSTVHGAVKFAFDFFFFPFLSAA
What is the function of this protein?
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814).  Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048).
What are the official names of this protein?
Wolframin.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Co-localizes with ATP6V1A in the secretory granules in neuroblastoma cell lines.
Protein: PSAB_YERPS
Sequence: MKNLFFSAYKKVFSYITSIVIFMVSLPYAYSQDVVVNTTKHLFTVKIGTTRVIYPSSSTKGVSVSVANPQDYPILVQTQVKDEDKTSPAPFIVTPPLFRLDAGLQGRVRIIRTGGKFPEDRETLQWLCLTGIPPKNGDAWGNTQNNPKNSSPTMDIQMSISTCIKLLFRPDKVKGDPTDSADSLTWRYKGNYLEVNNPTPFYMNFYSLRIGDEKINLSDLGSKDEIKNGSYVPPFSSRDFIIPVKNKGKATEVFWQVINDNGGVSREFKSTVQ
What is the function of this protein?
Required for the biogenesis of the pH 6 antigen.
What are the official names of this protein?
Chaperone protein PsaB.
What is the protein family that this protein belongs to?
Belongs to the periplasmic pilus chaperone family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SPTSA_DANRE
Sequence: MAFGDAWKQLSWFYYQYLLVTALYMLEPWERTIFNSLLISVAAMAVYTGYVFMPQHIMAILHYFEVVQ
What is the function of this protein?
Stimulates the activity of serine palmitoyltransferase (SPT).  The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity).
What are the official names of this protein?
Serine palmitoyltransferase small subunit A, Small subunit of serine palmitoyltransferase A, ssSPTa.
What is the protein family that this protein belongs to?
Belongs to the SPTSS family. SPTSSA subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YDBT_BACSU
Sequence: MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTVRFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMNTSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELDEERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMDWLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGIIEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHKKKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSVILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKKGRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG
What are the official names of this protein?
UPF0699 transmembrane protein YdbT.
What is the protein family that this protein belongs to?
Belongs to the UPF0699 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OSB8_DICDI
Sequence: MFSGALNYMKGLVGTNENLQVEESGDNKGDIEPEQRKGLLKQLSSYVGKDITSLISLPVWIFEPVSFLQVMSEPLQYNALLSKASKQDSEFLCLAYLAAFNCALYSTAVRTRKPFNPILGETFEIVDKKGEFRFLAEQVSHHPPIGVSETISEDYTLQLETLLKSKFYGNSSEVEIDGTNHFFNKKTNHHYTWNHLVTCCHNIIIGSLWLDHYGDLVIENHTTGSKAVLKFAKSGWLGAGRYGVTGEIVDCEGDVRYRITGKWNESIQLFQVMDNGSSSTTSTCLWEASKEPINNKFLFPRWVEENVIDLNDEYKKILPVTDSRLRADRIALEEGNLDVAAKEKHNLEEKQREDKRQRVAENKEWETAQFKKVDDAKFGYRWNYCGNYWEEREERVKAAASN
What are the official names of this protein?
Oxysterol-binding protein 8, OSBPh.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: RS20_ANAMM
Sequence: MPNHSSAKKMVRVIKERTFSNRVRKSRVRNSVKKFLAVLESKGHLEDAVTAFRAAESNIHKCVNKGVMHRNTAARKVKSLAAKLKAFDLSLQGTST
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: HCP_TRIV2
Sequence: MFCNQCEQTTRGDVCHQWGACGKSPEVDALQDLLVHCLRGLSQVALQAKSLGLATRETDEFTCEMLFSTLTNVNFSTSDFISFVNRAIALRESLKLQIQATGNAVIQSAINSFQPASDTQKQIQQGKDLEFEFISQSAKNVDIFSLKLTLLYGLKGVAAYAFHALELNQHDESLYIFFHEVLANLDAQDKSLQDWLDLTLKVGQMNLKAMELLDAGNTETFGHPTPTTVPLGHTVGKAILVSGHDLLALKAVLEQTSGTGIKVYTHGELLPAHGYPKLKQTHPHLYGHYGTAWQNQTHEFERFPGAIVMTTNCLMPPHETYKDKVFTLGPVGYPGLQHISIHDISLVIQKALELPGFTEDSEQKTVTTGFARNAVLGVADTVINAVKQGDIRHFFLVGGCDGAKPGRNYYSDLVEKIPNDCVVLTLGCGKFRFFDQNLGDIGGIPRLLDLGQCNDAYSAIQIAVALANTFEVNVNQLPLSMILSWYEQKAIAVLLTLLYLGIQNIRIGPTLPAFLTPNVVKLLSETFHLQLITTPEQDLAVCLG
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCM2_HUMAN
Sequence: MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232).  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425).  Required for the entry in S phase and for cell division (PubMed:8175912).  Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677).
What are the official names of this protein?
DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
Protein: SYIM_DICDI
Sequence: MISLNNSFFNKRVIVNSFNNYKRSFGTKSQNEESAIVDSNHSFAHTLNLPKTTFSMKANAATREPTLLKDPYKLYKWQLENNKGENWVFHDGPPYANGDLHMGHALNKILKDIVNRYKVLKGFKVNYIPGWDCHGLPIEQQAFKKLKKSSDMKASDIRKIAGDFARKEIEKQSKGFQEMGILGDWENPYKTLDYGYEVEQIQTFYDMFNKGYIYRGVKPVHWSPSSRTALADAELEYNNNHTSKSIFVKFNVKSLSNHILNNLPTTSDINKAEMVISAIIWTTTPWTIPANQAICVNSEMDYILVKPIESEQYRNEMFIISKERLESLTKSFNIGELKVILEFKGEQLKGTITKHPQYDRESPIITGDHVIEGSGTGLVHTAPGHGVEDFQICQQQYPDLKVLSPVNDLGCFTDEVGEKFVGLEVLGDGNEAVINDLETIGSLLHKEDYIHKYPYDWRTKKPIIIRTTLQWFVGLKNIQKTALQSIERVNMVPPSGSNRLSSMIGKRTDWCISRQRVWGCPIPVLYNCKTNEPLINDESINHIKELFGKFGSDCWFEMSTQQLLPPSLKDQHENFVKGTDTMDVWFDSGTSWRGVLVERGIIDKDTGRADIYLEGSDQHRGWFQSSLLTSVCVRDIEPYKNVVTHGFLLDESGIKMSKSIGNTIVPSTVIKGGPNKVQNPPYGVDLLRTWVASSDYSKDISIGPNILIKILDGIKKIRNTLRFMLASNFDFDPTIHAIPYEKLSSLDKYALHRVFKLQESVTRHYDQFQFQKVHTEIINFSIEISSFYFDVIKRHLYAESPNSHSRRSTQTVLFKMLDVINIALAPITVHTSEDVFLHQYQFKNNGKGLDKNLIENSVFAHGWDQLPSQYENELISNQFTNIIAIRDVVNRVLQSMRSQGIIGRSDETIMELTVTNEESSPFYDNLFAINSQLDDIFCVSNVLLKKFNTFEKDVEQQQQQQQQQQQQQPQQIEPNSKGEFIFNTIISNNSKQLGRIEVLLKISDKFKCPRCWRHTSIENDKVCKPCDSVLNSLK
What are the official names of this protein?
Probable isoleucine--tRNA ligase, mitochondrial, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: BAS1_HORVU
Sequence: DARARSFVARAAAEYDLPLVGNKAPDFAAEAVFDQEFINVKLSDYIGKKYVILFFYPLDFTFVCPTEITAFSDRHEEFEKINTEILGVSVDSVFSHLAWVQTERKSGGLGDLKYPLVSDVTKSISKSFGVLIPDQGIALRGLFIIDKEGVIQHSTINNLGIGRSVDETLRTLQALQYVKKPDEVCPAGWKPGEKSMKPDPKGSKEYFAAI
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.  May be an antioxidant enzyme particularly in the developing shoot and photosynthesizing leaf.
What are the official names of this protein?
2-Cys peroxiredoxin BAS1, chloroplastic, Thiol-specific antioxidant protein, Thioredoxin-dependent peroxiredoxin BAS1.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CINA_STRA3
Sequence: MRAEIIAVGTEILTGQIVNTNAQFLSEKMAELGIDIYFQTAVGDNEERLLSLLDIASQRSQLVILCGGLGPTEDDLTKQTLAKFLGKSLTVDLLASRKLDRFFASRPQFARTPNNERQAQLVEGSIPLQNLTGLAVGGIVTSKGVQYMVLPGPPSELKPMVMEQVVPILSNNGTKLYSRVLRFFGIGESQLVTILEDIIKNQTDPTIAPYAKVGEVTLRLSTKAENQDEADFKLDSLEKEILALKTLDNRKLKDLLYGYGDNNSMARTVLELLKVQNKTITAAESLTAGLFQSQLAEFSGASQVFNGGFTTYSMEAKSQLLGIPKKKLQEYGVVSHFTAEAMAQQARQLLKADFGIGLTGVAGPDELEGYPAGTVFIGIATPEGVSSIKVSIGGKSRSDVRHISTLHAFDLVRRALLKI
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: MOAA_SACD2
Sequence: MQNSTLIDSFGRQVTYVRLSVTDRCDFRCIYCMAEDMTFLPRKDVLSLEEFALLGRAFAELGVTKIRVSGGEPLIRKDVIQLFESLGAINSINDLCLTSNGSKLTELAKPLVDAGVHRINVSLDTLNEQRFKELTRFGDLNTVLKGIDAALNAGFKKIKLNSVVMKNYNLQEAADLATYALERGMDISFIEEMPLGEIHSHSRDVEFISSDELRNQLSNSFELTATNEHTGGPSRYWKARDYNAKIGFISPHSHNFCDTCNRVRVTASGRLLLCLGNEHSVDLRAILRAHPGEIEPIKEALINAMAIKPEKHEFNLEEEPQILRFMNMTGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: THII_SALPK
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALAQYREQLEGKTFCVRVKRRGKHEFSSIEVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKVDDGQMGVVLKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAIKAKIEAEEENFDFSILDKVVEEANNVDIREIAQQTQQEVVEVETVSGFGANDVILDIRSVDEQDDKPLKVEGVDVVSLPFYKLSTKFGDLDQSKTWLLWCERGVMSRLQALYLREQGFANVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_ECO57
Sequence: MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAENAPFQES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_STRP6
Sequence: MKRIAIDAMGGDNAPKAIVEGVNQVIEAFSDIEIQLYGDQTKINSYLIQSDRVAIIHTDEKIMSDDEPAKAVRRKKKASMVLAAKAVKEGKADAIISAGNTGALLAVGLFVVGRIKGVDRPGLLSTIPTVTGLGFDMLDLGANAENTVKHLHQYAILGSFYAKNVRGIANPRVGLLNNGTEETKGDPLRKATYELLTADNTISFVGNVEARELMSGVADVIVSDGFTGNAVLKSIEGTGISIMGQLKQIINSGGIKTKIGASLLKSSLYEMKKTLDYSSAGGAVLFGLKAPVVKSHGSSDVKAIFSTIKQVRTMLDTNVVGQLVEEFAKETQVND
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: H2A_MYTGA
Sequence: MSGRGKGGKAKAKAKSRSSRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTQKAAK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RSMC_SHIF8
Sequence: MSAFTPASEVLLRHSDDLEQSRILFAGDLQDDLPARLDTAASRAHTQQFHHWQVLSCQMGDNARFSLVATANDVADCDTLIYYWPKNKPEAQFQLMNLLSLLPVGTDIFVVGENRSGVRSAEQMLADYAPLNKVDSARRCGLYFGRLEKQPVFDADKFWGEYSVDGLTVKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATLAANGVESEVFASNVFSEVKGCFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPDVLDETFGFHEVIAQTGRFKVYRAIMTRQAKKG
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_SHEPC
Sequence: MTQDEMKKAAGWAALKYVEEGSIVGVGTGSTVNHFIDALATMKDDIEGAVSSSEASTQKMKALGIPVYDLNSVDRLSVYVDGADEINDRMDMIKGGGAALTREKIVAAVAEKFICIVDNTKQVNILGEFPLPVEVIPMARSYVARQLVKLGGDPVYREGVVTDNGNVILDVYNLKILNPKELESQINEIVGVVTNGLFAKRGADVLLVGTPDGVKTFTAK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: NHLC4_HUMAN
Sequence: MLGLEGPCWVGPGPDGGLAVSEEFGDVRLFGSARQPLGSLGGWTGHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQLLVADAKDNSIKVYQGLKELA
What are the official names of this protein?
NHL-repeat-containing protein 4.
Protein: RS7_ACICJ
Sequence: MSRRHSAVKREVLPDPKFGDVVISRFMNVLMYDGKKSVAESIVYGALDSLKKRGGQNADPVRLFHEALDNVKPAIEVRSRRVGGATYQVPVEVRSERRQALAIRWIIESARKRGEHTMEDRLSNELLDAVNNRGAAVKKREDTHRMAEANKAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: LPTD_HAEIN
Sequence: MNKKHTLISLAILTALYSQQSLADLHEQCLMGVPKFSGEVVTGDVNALPVYIEADNAEINQPNDATYQGNVDLKQGNRHLLAQSVQVKQSGNQSTPLRMAYVRNGFDYKDNQINMLGKDAEFNLDSHDGNLTNSEYEFVGRQGRGKADNITLHNNYRVMKNATFTSCLHGDNAWAVDASEIRQYVKEEYAEMWHARFKIHGVPVFYTPYLQLPIGDRRRSGLLIPSAGTSSQDGLWYAQPIYWNIAPNYDLTFTPKYMSRRGWQANGEFRYLTSIGEGKVAGEYLGKVRYSEYASDNRKRHLFYWNHNSSFLQNWRLNINYTRVSDKRYFNDFDSIYGRSTDGYANQYARIAYYQPNYNFSLSAHQFQIFDDIVNIGPYRAVPQLDFNYHKYDLANGWLNFKLHSQAVRFDNDSKLMPTAWRFHAEPSLNSLMSNKYGSLNIETKLYATRYEQKKGSGKNAEDVQKTVNRVIPQFKVDLQSVLARDITFLKEYTQTFEPHVQYLYRPYRNQSNIGSTLNNDYLGFGYDSALVQQDYYSLFRDRRYSGLDRISSANQVTLGGTTRFYDIAGEERFNLSAGQIYYLSNSRIDENPANKTPTSSSAWALESNWKISNKWYWRGSYQFDTHTNSTSLANTSLEYNPEKNNLIQLNYRYANQEYIDQNLGKSANAYQQDIQQVGLVVGWEIANNWAVVGRYYQDLALQKPVEQYLGVQYNSCCWAASVGVKRNVTNHQNQTRNEIVYDNSIGITLELRGLGSNDHQSGIQEMLEKGKLPYIRAFSLD
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: UBIC_DECAR
Sequence: MKRSKWRTRFAGAYCDPILRSWLTEPDSLTARCQRASSAFRVRLLRYGKGQALADEAVEGKAGRHSAWVREVVLECDGVPVIFAHTTLSTARRGRMTRWMAGLGSRSLGSLLFAYPGFKRGGIEFLRLDRCHPLYRRAAALGAGRKSLWARRSLHRLGGQQVLVTEVFLPAITLLK
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EDN1_FELCA
Sequence: MDYLPVLFSLLLVVFQGAPEAAVLGAELSTGPDSGGEKPAPSAPWRPRRSKRCSCSSLLDKECVYFCHLDIIWVNTPEHIVPYGLGSPSRSKRSLKDLFATKATDHRNRCQCASQKDKKCWTFCQVRKELRGQDSMEKGWDDQKKGKDCSELGEKCTHHQLVAGRKIRRLDAVRNSIKTAFRVAKLKAEIYREKKVTHNRTH
What is the function of this protein?
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).  Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity).  Also binds the DEAR/FBXW7-AS1 receptor (By similarity).
What are the official names of this protein?
Endothelin-1, ET-1, Preproendothelin-1, PPET1.
What is the protein family that this protein belongs to?
Belongs to the endothelin/sarafotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: XYLA_ACTSZ
Sequence: MTNYFDKIEKVNYEGADSINPFAYKYYNANEVILGKTMADHLRLAVCYWHTFCWNGNDMFGVGSLDRSWQKQTDPLAGAKQKADIAFEFLTKLGVPYYCFHDVDIAPEGNSYQEYVNNFNTIVDVLEQKQAETGIKLLWGTANCFTNPRYMSGAATNPNPEIFARAGAQVFNAMNATKRLGGENYVLWGGREGYETLLNTDLRREREQIGRFMQMVVEHKHKIGFKGTLLIEPKPQEPTKHQYDYDVATVYGFLKQFGLEKEIKVNIEANHATLAGHTFQHEIATAAALDILGSIDANRGDPQLGWDTDQFPNSVEENTLAIYEILKAGGLTTGGLNFDAKIRRQSIDPYDLFHAHIGAIDVLALSLRRAAKMLEDQTLQHIVEQRYAGWNGELGQQILNGKSSLEALAQAAQHLEPQPVSGQQEYLENLVNSYIYR
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14Z_RHOE4
Sequence: MAKKALVNKANKKPKFAVRAYTRCQRCGRPHSVFRKFGLCRICVREMAHAGELPGVRKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: NADM_SYNY3
Sequence: MQTKYQYGIYIGRFQPFHLGHLRTLNLALEKAEQVIIILGSHRVAADTRNPWRSPERMAMIEACLSPQILKRVHFLTVRDWLYSDNLWLAAVQQQVLKITGGSNSVVVLGHRKDASSYYLNLFPQWDYLETGHYPDFSSTAIRGAYFEGKEGDYLDKVPPAIADYLQTFQKSERYIALCDEYQFLQAYKQAWATAPYAPTFITTDAVVVQAGHVLMVRRQAKPGLGLIALPGGFIKQNETLVEGMLRELKEETRLKVPLPVLRGSIVDSHVFDAPGRSLRGRTITHAYFIQLPGGELPAVKGGDDAQKAWWMSLADLYAQEEQIYEDHFQIIQHFVSKV
What is the function of this protein?
The Nudix hydrolase domain is active on ADP-ribose, (2')-phospho-ADP-ribose, IDP-ribose and NADPH.
What are the official names of this protein?
Bifunctional NMN adenylyltransferase/Nudix hydrolase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the archaeal NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.