PharMolix/UniProtQA huggingface dataset:
Protein: RS12_BEII9
Sequence: MPTISQLIRKPRHEKAYREKARHLEACPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHILRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RPOA_MYCSK
Sequence: MLISQRPTLSEETVADNRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTDIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPEMHIATLNDKGKLEVELVVERGRGYVPAVQNKASGAEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLILDVETKNSITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPATFDPSEVAGYDAATGTWNSDAGYDLEDNQDYAETEQL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: REP7_ECOLX
Sequence: MAGLKNTSYNAVHWSQLAPEEQIRFWEDYEAGRATTFLVEPERKRTKRRRGEHSTKPKCENPSWYRPERYKALKGQLGHAYNRLVKKDPVTGEQSLRMRMSRHPFYVQKRTFVGRKYAFRPEKQRLLDAIWPVLVSFSDAGTHTVGMSVTRLAEEISPKDSEGHVIPELEVTVSRLSRLLAEQVRFGVLGVSEETMWDREHRQRLPRYVWITPAGWQMLGVDMVKLHEQQQKRLRESEIRQQLIREGVLREDEDISVHAARKRWYLQRSQDALKKRREKAAASKRANRLKKLPVDQQIYEMAEYLRKRLPPDEAYFCSDDHLKRLAIRELRQLELTLAAPPPH
What is the function of this protein?
Binds specifically to the motif 5'-AANCYGCAA-3' (repA box) in the origin of replication.  Acts preferentially in cis; binding to the repA boxes is sequential, with the boxes closest to the DnaA binding site being occupied first.  It is involved in promoting open complex formation by unwinding the oriB at sequence 5'-TCTTAA-3'.
What are the official names of this protein?
Replication initiation protein, Replication-associated protein.
Protein: Y635_MYCTU
Sequence: MALSADIVGMHYRYPDHYEVEREKIREYAVAVQNDDAWYFEEDGAAELGYKGLLAPLTFICVFGYKAQAAFFKHANIATAEAQIVQVDQVLKFEKPIVAGDKLYCDVYVDSVREAHGTQIIVTKNIVTNEEGDLVQETYTTLAGRAGEDGEGFSDGAA
What are the official names of this protein?
UPF0336 protein Rv0635.
What is the protein family that this protein belongs to?
Belongs to the UPF0336 family.
Protein: SYP_LEPBL
Sequence: MKASKYILPTEKENPSDAVVASHRLMIRAGLARKSSAGLYFYLPLGLKILQKIKQIIREEMNKTGALEFDLPILTPSDFWEQSGRWTAMGKEMFRIKDRHDLSYALGPTHEESFSFLLKPLLKSYKDLPLNVYQIQTKFRDEIRPRFGVIRSREFIMKDAYSFHIDDVSLDETYQSMRAAYRKIFDRCGLKTIPVQADSGSMGGSASEEFMVVSPIGEETLLLCNSCGYSSNSEKTPLVLKKENVSSASVEKKEISTPGKKTIVEVSAFLGIPESTTIKAATLKSEKKKILVYLRGDLELNLHKLHSLLRIVDSEPMTDAEIRELGLVPGFIAPVAPNDKVKVLYDRSLQKDFPYVVASNKEDFHTQGFVLEKEVSGLPEFADVALAREGDLCPNCNAPLKAEKGIEVGHIFKLGEKYTKAFGIQVLDQNGKARTLTMGCYGIGVNRTMATVIEQRNDEKGIFWPISIAPFEVTLVSITKGEEQYSKAEEFYNVLKNENLEVFWDDRDVGPGFKLKDSELIGFPIRVTIGKKFFENGEISIYNRKADKEESFVFAGFENLIARVESLRQELFAELE
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_ELUMP
Sequence: MAKQIVYGDEARAKMKAGIEKVAKAVSVTLGPKGRSVVLEKKFGSPLIIDDGVTIAKDIELEDKFENMGAQLIREVASKTNDIAGDGTTTATVLTHAILTEGIKNITAGANPTLVKKGIEMAVETVKEELKKMQRPVETKEEKAQIATISANDRMVGELIAEAMEKVGHEGVITVEEGKTATTELQVVEGMQFDRGYISPYFVTDSERMECVLEDCQIILADKKVSSMNELLPLLEGIVKNGRNFLIIAEDVDGEALATLVVNRLRGTLKGCAVKAPGFGDRRKEMLEDIAILTGGQVIAEERGMKLETATLDMLGSAKRVVIDKENATIVSGEGDKKKIEARAEQIRKQIENSTSDYDKEKLQERLAKLSGGVAVISVGAATETEMKAKKAKVEDAKNATKAGVEEGLIPGGGVALTRCEGAVGKLKADNEDVQTGINIVKKALTAPLYQIAFNAGLDGSVVVENVRNAKGNQGFDADTGEYVDMIKAGVVDAVKVVRIGLENAASIAATVLLTEALVADIPEEKGAAPMGHPGMGGMGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SERF2_PONAB
Sequence: MTRGNQRELARQKNMKKQSDSVKGKRRDDGLSAAARKQRDSEIMQQKQKKANEKKEEPK
What is the function of this protein?
Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity).  Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (By similarity).
What are the official names of this protein?
Small EDRK-rich factor 2.
What is the protein family that this protein belongs to?
Belongs to the SERF family.
Protein: TUBE_BPLP2
Sequence: MKLDYNSREIFFGNEALIVADMTKGSNGKPEFTNHKIVTGLVSVGSMEDQAETNSYPADDVPDHGVKKGATLLQGEMVFIQTDQALKEDMLGQQRTENGLGWSPTGNWKTKCVQYLIKGRKRDKVTGEFVDGYRVVVYPHLTPTAEATKESETDSVDGVDPIQWTLAVQATESDIYSNGGKKVPAIEYEIWGEQAKDFAKKMESGLFIMQPDTVLAGAITLVAPVIPNVTTATKGNNDGTIVVPDTLKDSKGGTVKVTSVIKDAHGKVATNGQLAPGVYIVTFSADGYEDVTAGVSVTDHS
What is the function of this protein?
Forms the cylindrical rigid tail tube with a 4 nm wide central channel for DNA ejection.  The tube is composed of 31 hexameric rings.
What are the official names of this protein?
Tail tube protein, TTP, Gene product 11, gp11, Major tail protein, MTP.
What is the protein family that this protein belongs to?
Belongs to the skunalikevirus tail tube protein family.
What are the subcellular locations of this protein?
Virion. Note=Constitutes the tail tube.
Protein: MINC_LISMC
Sequence: MKKNVQIKGTKDGISIFLSDKASISELQQELTQLLADQKQNPYSGEKLEVQVQIGNRLFSEEEEREISTIIHENSQMKISAFYSNVMSKDEAKKWKENDQIFSMATIIRSGQVVQVPGDFLLIGDVNPGGQIRSNGNVFVLGNIKGIIHAGFEGNGNAIVAGKFLYPSQVRIADKVYGFDSEDYKEVTETDLFSAFVNDAGEIVIDGIHKIRKIRPEISNFQGGR
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: CDPAS_PYRFU
Sequence: MHPILEAFWYILPAYFANSSPVILGGGTPIDFGKTWRDGRRIFGDSKTWRGFLGGLTVGTLIGVIQQIIYPYYPSLSLAFKVSFLLALGALVGDLIGSFIKRRLNLPPGYPAVGLDQWGFLISALCFAYPVHTIPTGEVLLLLVVTPLIHWGTNVLAYKMKWKSVPW
What is the function of this protein?
Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP.  This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
CDP-archaeol synthase, CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-archaeol synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMD_SHIF8
Sequence: MAQFYSAKRRTTTRQIITVSVNDLDSFGQGVARHNGKTLFIPGLLPQENAEVAVTEDKKQYARAKVVRRLSDSPERETPRCPHFGVCGGCQQQHASVDLQQRSKSAALARLMKHDVSEVIADVPWGYRRRARLSLNYLPKTQQLQMGFRKAGSSDIVDVKQCPILAPQLEALLPKVRACLGSLQAMRHLGHVELVQATSGTLMILRHTASLSSADREKLERFSHSEGLDLYLAPDSEILETVSGEMPWYDSNGLRLTFSPRDFIQVNAGVNQKMVARALEWLDVQPEDRVLDLFCGMGNFTLPLATQAASVVGVEGVPALVEKGQQNARLNGLQNVTFYHENLEEDVTKQPWAKNGFDKVLLDPARAGAAGVMQQIIKLEPIRIVYVSCNPATLARDSEALLKAGYTIARLAMLDMFPHTGHLESMVLFSRVK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: BLN06_BRELC
Sequence: MTLLHCWLLLVGHLASTAYADFITKDFKSLPPPAYDTNATQALVPYNAALEERNGPSSSTALLQYIDHKPGLMKKLLAGLSIRFAPPTMKVISTPTDMLRIDKIKNNIIKSSQWKRWARSLLEQNSMQNSHVIITKKMMDDLKPTNFFLVLLEASKDKNTKAVAKILEETQFARWCTIEHESISPMEFYDVLQLNLNEPIAYMERLPVLLRYWKYYKSVHSPMSSVATPKDIIDKQTVNRFGPYWKHTGEIAELLRLDFDSDSFFNHPARNVWLDLMKTYLDDTKTAEPLMIKTFQLLGNAAAKNLQNNVYSPIHFAERWIQANLQPIDVVTILGLDIHDSNLATNSAFSFLKVFIEKFLVNHPEADTTVVKIFSRLGSDESEKALALRKSFVSFFLRTPKFTPKTVMSIFDLTISADYVEKNPVWAIWMEYVNVYLVKNKVCPEGPLADTLEFLGSTAAADGVVRKKSIELLYSSWSGKTSQDTRIKQFLTAAARLNQLEL
What is the function of this protein?
Secreted effector that triggers a robust hypersensitive response (HR) in Lactuca serriola LS102.  The response to BLN06 was visible as chlorosis but not as strong necrosis.
What are the official names of this protein?
RxLR effector protein BLN06.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane.
Protein: SLA5_MACLB
Sequence: MGRSISVSFGLLVVFLSLSGTGADQDCLPGWSSHEGHCYKVFNLDKTWEDAEKFCTEQANSGHLVSIDSKKEANFVAELVSQNIKETRRTDFVWIGLRAEDKRQHCSSEWSDGSSINYQNWIEAESKKCLGLEKQTRYRKWVNLNCGKPYRFTCEI
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec A5, C-type lectin A5.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPD_SINFN
Sequence: MNDLKPFVAKVAAREALSREDARAAFEIIMSGAATPSQIGGFLMALRVRGETVDEIVGAVGAMRARMLPVEAPEDAIDIVGTGGDGAGTYNISTLASLIVAGAGVPVAKHGNRALSSKSGTADALSCLGVKLDIGPEAIARCIREAGVGFMFAQQHHSAMRHVGPTRVELGTRTIFNLLGPLSNPAGVKRQLVGVFAPQWVDPLAEVLRDLGSESIWVVHGEGLDEITTTGVTKVAELKDGKIRSFELTPESFGLARTTLDALKGGDGAHNAAALQAVLDGEENAYRDISLANAAASLMIAGRATDLAEGMAIGREALSSGAAKAALQRLITVSNAA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: PIN5A_ORYSJ
Sequence: MIGWGDVYKVVAATVPLYFALFLGYGSVRWWRIFTREQCDAVNRLVAFFALPFFTFEFTLHTDPFQVNYRAVAADVISKAVIVAVIGAWARFMSKGGCAVSWSITSFSLSTLTNSLVVGVPMARAMYGEWAQQLVVQLSVFQAIVWLTLLLFVLEVRKAAIGMYVDGAEAAAAAGKDVEAAGAAAAAGTVVVAAAAGKPSLWALVKVVAHKLARNPNTYASFVGITWACLANRLHIALPSAFEGSVLIMSKSGTGMAMFSMGLFMAQQEKIIACGTSFAALGLVLKFALGPAAMAIGSIAVGLRGDVLRVAIIQAALPQSITSFIFAKEYGLHADVLSTAVIFGMLVSLPLLVGFYIVLELIR
What is the function of this protein?
May act as a component of the auxin efflux carrier.
What are the official names of this protein?
Probable auxin efflux carrier component 5a, OsPIN5a.
What is the protein family that this protein belongs to?
Belongs to the auxin efflux carrier (TC 2.A.69.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NASD_HALMT
Sequence: MASKKEQWKSDLYGDAVRDELEAFAEEGFESIPEDERDKWFTRFKFWGVFQQRTGQESYFMMRLTNANGVLEPGQLRTIAEVARDYATGPVDNPEFGNGWVDLTTRQSIQLHWLELEDIPEIWEQLESVGVTSRSAGGDTMRNITGCPVAGKDTHELVESKPLLDRFQSELREDDALSNMPRKFNISVTGCREGCAQDSINDIGLEPARKEVDGEVITGFNVRVGGGLGSRKPRVARSLDVFVADEERAYEVVRGFVELYHDHGNRDVRARARSRFFVDDWGTEKIRDRLESEYLDFELQSAGEDIRDEYTYNAGRPQSAGKSDHVGVHEQSDGRYYVGLSVAVGRLTAADALELADLADKYGSGKIRLTRRQNPIVMDVPAGALDDLLAEPLLSKHTPEPNPFQRGTVACTGTEFCSLALTETKARTARMLRWLRDNVEVPDDVHQLKIHYSGCTADCGQANTADIGLFGMRAQKDGEMVEAMDIGVGGGIGDEPSFVEWIHQRVPADEVPGAIASLVEAFAAHRTAGQTFRQWVEAEGPDAVAEYCEPIETDFEAPYMHDAKQSWYPFADEDEPPKTEQPMTSD
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonium in the nitrate assimilation pathway, using ferredoxin as the electron donor.  Can use reduced methyl viologen but neither NADPH nor NADH as electron donors.
What are the official names of this protein?
Assimilatory ferredoxin-dependent nitrite reductase, NiR, Ferredoxin:nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: KDSB_BURM9
Sequence: MTSPLPFVAVVPARLASTRLPNKPLADLGGKPMVVRVAERAREAGAQQVLVASDAQRVLDAVREHGFDAVLTRADHPSGTDRLAEVAAKLGFDDDTIVVNVQGDEPLIDPQLVRDVASHLAAHPSCAIATAAHPIHEAHEVFNPNYVKVVLDAHGVALYFSRAPIPWSRDAYLPHWPNVAAMPAPTCPVYRHIGLYAYRARFLRTYPTLAQAPIEAAEQLEQLRAMWHGERIAVRVTEHAPEAGIDTPADLERVQALFRSRAK
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_SPHAL
Sequence: MARFIFITGGVVSSLGKGLMAASLAALLQARGYRVRIRKFDPYLNVDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFTGVAARQSDNVTSGRIYQGIIAKERRGDYLGATVQVVPHVTDAIKDFARAETDDLDFVLCEIGGTVGDIESLPFIEAIRQLKNEVGRDNAISVHVTLVPYIAAAGELKTKPTQHSVRELASLGVQPDILLCRCEKPLPDSERAKIALFCNVRKEAVIPALDADSIYSVPVQYHGEGLDSEVLRAFGILDAPAPDLTAWYDIMDRKQHPEGEVTIGVVGKYVSLPDAYKSLNEALVHGGMAHRVKVNIRWLDAEMFERDEDLVANLEPLHGILVPGGFGERGSEGKIASVRFARERNVPFFGICLGMQMACIEAARNTSGIANASSTEFGPTDEPVVGLITEWMSAEGLQKRGANTDLGGTMRLGAYDAKLSPNSHVASVYGTNEISERHRHRYEVNGAYRERLEKGGLVFSGMSPDGMLPEIVERPDHPWFIGVQFHPELKSKPFDPHPLFAGFIEAAVKQSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PYRG_NOSP7
Sequence: MTKFIFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYINIDPGTMSPFQHGEVFVTQDGAETDLDLGHYERFTDTSMSRLNCVTTGSIYQAVINKERRGDYNGGTVQVIPHITNEIKERILRVAKSTNPSVVITEIGGTVGDIESLPFLEAIRQFRKEVGRQHVLYMHVTLVPWIASAGEMKTKPTQHSVKELRSIGIQPDILVCRSDRPLPKGLKQKLSGFCDVPEECVITSQDAKSIYEVPLNLEREGMAEQVLNLLQMEQRQPDLTQWQTLVQRLHTPKHELEIAIVGKYVQLSDAYLSVVEALNHAAISTYGKLRLRWVNSEDLENESAETHLGGVDGVVVPGGFGVRGVDGKIAAIKYARDRQIPFLGLCLGMQCSVIEWARNIGGLTDANSAEFDPHTTNPVINLLPGQQEVVDLGGTMRLGLYPCRVLPDTLAFKLYQEDVIYERHRHRYEFNNAYRDLLLKSGYAISGTSPDGQLVEIVELPKHPFFLACQFHPEFQSRPSSPHPLFKGFIQAAIALSLSTSTTPTPLEVS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: YBEY_DESHY
Sequence: MYLDINWEEDSIPENERGSLTGLLEQGIAKAVHLSAESEEAEVSLTLVDDARIHELNRDYRGVDRPTDVLSFALQEERSDEPDILDYEDHLLGDIIISVERARAQAIDYGHSFERELVYLAVHGTLHLLGYDHMEEADKEKMRRQEEAVMSQIGLLR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYRR_ECOLI
Sequence: MRLEVFCEDRLGLTRELLDLLVLRGIDLRGIEIDPIGRIYLNFAELEFESFSSLMAEIRRIAGVTDVRTVPWMPSEREHLALSALLEALPEPVLSVDMKSKVDMANPASCQLFGQKLDRLRNHTAAQLINGFNFLRWLESEPQDSHNEHVVINGQNFLMEITPVYLQDENDQHVLTGAVVMLRSTIRMGRQLQNVAAQDVSAFSQIVAVSPKMKHVVEQAQKLAMLSAPLLITGDTGTGKDLFAYACHQASPRAGKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEIGEMSPRMQAKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLVELVQKGMFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLAADLNTVLTRYAWPGNVRQLKNAIYRALTQLDGYELRPQDILLPDYDAATVAVGEDAMEGSLDEITSRFERSVLTQLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSQKKNEE
What is the function of this protein?
Dual transcriptional regulator of the TyrR regulon, which includes a number of genes coding for proteins involved in the biosynthesis or transport of the three aromatic amino acids, phenylalanine, tyrosine and tryptophan (PubMed:4887504, PubMed:4399341, PubMed:334742, PubMed:1860819, PubMed:8449883, PubMed:7961453, PubMed:7798138, PubMed:14614536, PubMed:15049824).  These three aromatic amino acids act as effectors which bind to the TyrR protein to form an active regulatory protein (PubMed:4399341, PubMed:334742, PubMed:1860819, PubMed:8106498, PubMed:7961453).  Modulates the expression of at least eight unlinked transcription units, including aroF, aroG, aroLM, aroP, mtr, tyrA, tyrB and tyrP (PubMed:4887504, PubMed:4399341, PubMed:334742, PubMed:1860819, PubMed:8449883, PubMed:7961453, PubMed:7798138, PubMed:14614536, PubMed:15049824).  In most cases TyrR acts as a repressor, but positive effects have been observed on the tyrP gene, which is repressed in the presence of tyrosine and activated at high phenylalanine concentrations (PubMed:334742, PubMed:1860819, PubMed:8449883, PubMed:7798138, PubMed:15049824, PubMed:8407813).  Is also involved in activation, but not repression, of mtr expression in association with phenylalanine or tyrosine (PubMed:2061290, PubMed:8449883, PubMed:8407813).  Acts by binding specifically to TyrR boxes in the promoter region of the target genes (PubMed:1860819, PubMed:8449883, PubMed:7961453, PubMed:8947567, PubMed:10197993).
What are the official names of this protein?
HTH-type transcriptional regulatory protein TyrR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNSO_PENEN
Sequence: MESTDSSPPLSMTDTEKKGDAVTTVTDESSVSEYERFLHLENVFSGASRKKLLRKLDLRLLPTLSFLYLMCSLDKSNAGNAKLFGLLEDLGMSGTQYNLALMYFFFTYGLSEPVSNIMLRRVGPKIWFPFIVCAWGLITTLTSQASSYAGFVVIRLMLGITEAGLYPGAYFILSMWYTPKEIGTRMAIFYGANTTAGAFGGVIAYGVGSLDGNLGWRAWRWLFLIEGCITIFAGLACLFCLPAFPHQYQAGKGTKWLTDEELEYASLRVKYANGPVSSTYTFRWSDVVAAAKDRKTYFMMMLFWWGGSVPTYSLSYTLPTMVANLGYTAVKAQVMTTPPYIFATCVCVAVGYISDQTQRRYLCIMGAYTLGLIGIIILWITVHHPSIPGVSYFAIFLAAAGYSAQAPIVGAWTASNITNPSKRAAAIGLLMLLGSVGGGSIGSNIYISSEAPTYPLGFGFSVGATVLGAMIPATIHWFLMRKENKRRGGLDVAEIERKYTTEELGEMGEDSPLFRFVL
What is the function of this protein?
MFS-type transporter; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals (PubMed:25571861).  With the MFS transporter cnsL, is most likely responsible for cummunesins secretion and thereby may contribute to intrinsic resistance (Probable).
What are the official names of this protein?
MFS-type transporter cnsO, Communesin biosynthesis cluster protein O.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ASI3_YEAST
Sequence: MSTNILQHVKQLLHNRDVFSFFHNKTGNLNYLDNTTQKPEVFVSPNSTIVSAPTLDSFQALMEKGNFTTLQLAKVGIRMFFSYSVSKYAVLCFSTAIILNRLTVMSSLRSNSTNIRLPLWSKTLLHLVATLSLVKALLQILSQFGLMHELHVSDTDFYALSVYLFVALSDCIEIFISSTTNVPSLICSDFSIWGLSLNLYIISKMPAGQQHIGDNVELLGAVFHRLVIHLVELFHIRAYRLCGEVILNAGFFTAFVTRTYLNGLDFINICLIHNYFPGFFYISTILLASIGIFLKALFTSNPFRSLYSRYKNLEKWWRSNNYNGEEEFNEIALSLCLLLTSNDYKIFKKSDNVKSVDEVAAFSNSYVVSGHLNQLQSTPEDLLSRKEMTTDSQLPGFARTYLGLFELVRTIILTYSRLLKNLLWSKNFESSIDKKPRVGKRKKRDLNKYVTEKNYKKFLYKPDVKELNIESDLRSLELLLPEDDSSKDYFPPRKIDESVSDEEFDSDMESQLIIDEEKELTHLSSNAVDSDDLEEIAWNISMWSILNYEMDVHNKVNGPLTRSQYGKRNPQGVLVDVVIERLLHHTNSRYMYKRLNMKDDDKLEFKFDFAFDSCDEVEEMDLSCLICKVNKRNIVTWPCRCLALCDDCRISLGYKGFATCVSCDSEVKGYSKLNIV
What is the function of this protein?
Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain.  Required for ERG11 degradation (PubMed:25236469).  Negative regulator of SPS-sensor signaling.  Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444).  Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748).
What are the official names of this protein?
Probable ERAD-associated E3 ubiquitin-protein ligase ASI1, Amino acid sensor-independent protein 3.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein.
Protein: PDIA3_MESAU
Sequence: RLAPEYEAAATRYGVSGYPTLKDGEEAGAYDGPRTADGIVSHLKFISDKDASVVGFFRDLFSDGHSEFLKFAHTNVESLVKEYDDNGEGITLFRPSHLANKFEDKDLLTAYYDVDYEKKTFSHELSDFGLESTTGEVPVVAIRFVMQEEFSRFLQDYFDGNLKRYLKSEPIPETNDGPVKMDATANDVPSPYEVKGFPTIYFSPANKK
What is the function of this protein?
Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (By similarity).  Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity).  Association with calcitriol does not affect its enzymatic activity (By similarity).
What are the official names of this protein?
Protein disulfide-isomerase A3.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome.