PharMolix/UniProtQA huggingface dataset:
Protein: FPG_AFIC5
Sequence: MPELPEVETVRRGLIPAMEGVRIARVTAHRNDLRFPLQTDFVARLGGRVVTGLGRRAKYLLADLDSGDVLLMHLGMSGSFRVAMDGGQEATPGIFHHPRSESRTHDHVVFEMDNGAVISFNDPRRFGYMKIVARADLEAEPFLKALGPEPLGNEFNAAMLAQACAGKATSLKAALLDQRVVAGLGNIYVCEALYRAHLSPKRRASTLASRTGAPSGHAERLVPAIRTVLNAAIEAGGSSLRDHRQTTGELGYFQHSFQVYDREGEPCRTRGCKGTVKRFTQNGRSTFWCPSCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: ILVC_HELAH
Sequence: MALSVYYDKDIDLGVIQSLQVGIIGYGTQGEAQALNLRDSKVKVRVGLYQGSLSIPKAKAEGFEVLEVKELVQKSDVIMALLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVSFKKGVGVILVAPKGPGSALREEYLKNKGLYHLIAIEQENSKNNAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAVVRMGFETLIKAGYPEELAYFECVHEVKLVADLLHYKGVEGLRKHISNTAEFGAIKAREPMENLLEKRMQKILKKIQNGSFAKDFLLEKSLNYPRLNTERKALKETKIEQVGEILRTPFNHEK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: CHSJ_PETHY
Sequence: MVTVEEIRRAQRAEGPATIMAIGTATPSNCVDQSTYPDYYFRITNSEHKTELKEKFQRMCDKSMIKKRYMHLTEEILKENPNICEYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRSSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPNDTHLDSLVGQALFGDGAAAIIIGSDPLPGVERPLFELVSASQTLLPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIQKSLVEAFQPLGISDWNSIFWIAHPGGPAILDQVELKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASSKEGLGTTGEGLEWGVLFGFGPGLTVETVVLHSVST
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase J, Naringenin-chalcone synthase J.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: UQCC6_PONAB
Sequence: MPAGVPMSTYLKMLAASLLAMCAGAEVVHRYYRPDLTIPEIPPKRGELKTELLGLKERKHKPQISQQEELK
What is the function of this protein?
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation.  Mediates early complex III biogenesis.  Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity).  Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
What are the official names of this protein?
Ubiquinol-cytochrome-c reductase complex assembly factor 6, Protein BRAWNIN.
What is the protein family that this protein belongs to?
Belongs to the UQCC6 family.
Protein: RHLB_ECO8A
Sequence: MSKTHLTEQKFSDFALHPKVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTSTFHYLLSHPAIADRKVNQPRALIMAPTRELAVQIHADAEPLAEATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMYDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEQMNNAEYIEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILDEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIPVSKYNPDALMTDLPKPLRLTRPRTGNGPRRTGAPRNRRRSG
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA109_DANRE
Sequence: MPGSALLSLQQELRRGFEALKAAKDTFDGGHAECQELVSSLGNLAPQLKALKQVQISETPLSGFPCLQQRLHYKLSLAVDALLAKLAEKMAALQKVWDAFAQQVFTVVQLYEKNTDALDISVCVSRSAVCPSVSDMLEWLQDADRYYRLQLMQSRLLLQTLTPTDLTSMETAPNRWRSVRSARQEERIADALCQVSIFLETE
What is the function of this protein?
Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (By similarity).  Plays an essential role in early embryonic development (PubMed:12006978).
What are the official names of this protein?
Ribosome biogenesis protein C1orf109 homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: EX7S_ACTP7
Sequence: MAKKPTQDFESTLKELEAIVSHLETGELPLEEALNEFETAVKLVQQGQERLQKAEQRIQILLNKNDQAELSDYE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU6M_CAEBR
Sequence: MIKLFFVLAIFSSIISYMNIDPMKSSFFLIFSLLFSMPIISMSMHIWFSYFICLLFLSGIFVILVYFSSLSKINVVKSYMSLFLLLISIIYFSPVSMEYTNYLGLSGFYYSIYWFIFSFILICLLFFMNFSSYFLNFSGALRKV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: CSPA_STAES
Sequence: MKQGTVKWFNAEKGFGFIEVEGENDVFVHFSAINQEGYKSLEEGQSVEFEVVEGDRGPQAANVVKL
What is the function of this protein?
Involved in cold stress response.
What are the official names of this protein?
Cold shock protein CspA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHSA_DICD3
Sequence: MLNDILSRVARVGAMHAGNRPNPPDDRPQPCRGKPPTSPGKTIKHKSFLGALAGAVAGALVAAAVAAAAVFLVGVTGGLAVAAVGALAVFAAGDLISAVTNKVSAMVDSASPAFGPVASGSGNVFVEKQPVARATKDTVACTKHNSPQLIAQGSESVFVNDAPAARIDDKTVCGATVKEGASTVFFGSGQGTYLDIADEFSWWEKALLIAVEFLVPPSRGMLKGLGKLFIRGPKAVLRGSRAGAKWIAGRLADKSSCASKAFKASSGLTRAKAAVKAFLKDPVYIASGEVIESRTDIELGQTLPLAFERTYRSASVHIGLLGRGWHDSWSEVATVTRDGLNTHVVITLAQGYDIDFTFHQDVQAVYCPHYPEFTLHRRGDGFSLWHRDQQTWRDFSVVQGERRLLSAIHDSHDNRIELVRDPKGYLRQVRHSDGVTLLLVWQGEFLHQIQRIDGGQKTLLAEYRQDEQGRLVEANATQAYHLYYDYDAAHRLTRWHDNDQTWARYEYDAQGRCVYTTCADGFLTARFDYLPDRVVMTDGLGQCSEFGFNDLFLMSWEKSPLGHVTRYEYDDYGNLLREISPAGRVVEFTYLDDTGRVSTFTDASGHQWQYDYDAAQRLCGVTDPLGREWGWMYDAEGNPERLTGPDASEVRFTWNRYGLLTQVSDAAGEVQARLQYDHRQRLLSATDAESRTRQLRYDGQDRVVQWQRADGARFRLGYRRASWTLPEQLIRPDDKEEQRQYDRHNNLLSYVDGNGALWRQTFGPFDLLTARTDAEGRTWHYAYDKESQQLTTVIAPDGSHWQWWLDADGRVIRERDMTGTETHYDYDEDGLCIRVRNGEGDTRHFLYDARGLLLRETAPDDTLHYRYDAVGRLTEVSSSTAHVQLEYDLRDRMVREWHNGTLLTRQVDDAARTVTRTLTWDGDADDTINALAPLTSLFHYTRTGELRQVQLPDGADLTLTHDAAGRESHRTGGSGFVQQREYDVMGWLTREMSGAQHDGHLLATQTREYRYDGAGNLTGVRHNRDAEGYRLDATGRVQEILSGGAGKPVDTTARFLYTRTGLPQEAGRLTEWQAGRLVQHDDTHYQYDRAGRLIRKQVVQPGYRPQVWQYRWDSRNQLRVVDTPNGERWLYRYDPFGRRVGKRCDQKAEEIRYLWDGDQIAEIRHYRHGQLIQRRHWVYNGWELVVQQRQHTGGDWETDFVTSSQNGTPQALFTPDGTLRWQAPKATLWGQRQAEKSESPDPGLAFAGQLRDSESGLCYNRFRYYDPAGGCYVSPDPIGIAGGESNYGYVSNPMCWVDPFGLAKCPTLAHGANGEILSAKATVSKAELRTGSGTNQSSRDYARSLGNQTDDAGHILGNVLGGQGGKGNVFPQLPAINRGQYRDFEKVVKDYIGQHGSVDIEWAFKYGNGGTRPTEIYYDVYQNGQKVFGRIFNN
What is the function of this protein?
Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  This protein may be a nuclease that is specifically inhibited by its cognate immunity protein RhsAI.  Upon expression of the C-terminus (residues 1284-1434) in E. coli growth is inhibited, cells elongate, nucleoids condense and plasmid DNA is degraded; these effects are blocked specifically by cognate immunity protein RshIA.  Cell contact is necessary for growth inhibition.
What are the official names of this protein?
Probable deoxyribonuclease RhsA, DNase RhsA, Toxin RhsA.
What is the protein family that this protein belongs to?
Belongs to the RHS/WapA nuclease family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PLAG1_RAT
Sequence: MATVIPGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSELLSKPFTNTLQLNLYNTPFQSMQSSGSTHQMITTLPLGMTCPIDMDTVHPSHHLAFKCPFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSQASSSKLGLEPQSGSPDDGAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQDEAHSSVSQLPTQTQDLQDPANTVGLGSLHSLSAAFTSSLSSSTTLPRFHQAFQ
What is the function of this protein?
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed.  Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction.  Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas.  Cooperates with CBFB-MYH11 (By similarity).
What are the official names of this protein?
Zinc finger protein PLAG1, Pleiomorphic adenoma gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited.
Protein: VP6_BROAA
Sequence: GFIGDIWSGIQG
What are the official names of this protein?
Venom peptide 6, BaP-6.
What are the subcellular locations of this protein?
Secreted.
Protein: ACD6_ARATH
Sequence: MDSSGADLDRIEAQRSMLVSHDQRKDFSHSGGVGTTSPTGDTEPVPKFRTNLKLSDLFALPGEDVEMTPEIFGGMSNGEKECLEKLRSNGTPMERVKSNTGDSILHIAAKWGHLELVKEIIFECPCLLFEQNSSRQTPLHVATHGGHTKVVEALVASVTSALASLSTEESEGLNPHVLKDEDGNTALYYAIEGRYLEMATCLVNADKDAPFLGNNKGISSLYEAVDAGNKFEDLVKAILKTTDDNVDREVRKFNLDSKLQGNKHLAHVALKAKSIGVLDVILDEYPSLMDEQDEDGRTCLSYGASIGYYKGLCNILNRSTKGVYVCDQDGSFPIHSAAKNEHYEIIKEFIKRCPASKYLLNRLGQNILHVAAKNEASLTAYMLMHDKDTKHLGVGQDVDGNTPLHLAVMNWDFDSITCLASRNHEILKLRNKSGLRARDIAESEVKPNYIFHERWTLALLLYAIHSSGFESVKSLTIQSVPLDPKKNRHYVNALLVVAALVATVTFAAGFTIPGGYISDSKKPNLGRATLATNPTLFIFLLFDILAMQSSVATICTLIWAQLGDLALILKSLHVALPLLLFSLLCMPVAFLFGVITAIAHVKWLLVTISIISGGFFLFAIFILGPHVMLQRSHLPPSSGIFLKTFMLTIDISELFVILIKACFGCVACSE
What is the function of this protein?
Dose-dependent activator of the defense response against virulent pathogens, including bacteria, fungi and oomycetes, that acts in a positive feedback loop with the defense signal salicylic acid (SA) (PubMed:14507999, PubMed:20520716, PubMed:10488236, PubMed:16297071, PubMed:19144005).  Regulates the salicylic acid (SA) signaling pathway leading to cell death and modulating cell fate (e. g.  cell enlargement and/or cell division) (PubMed:14507999, PubMed:10488236, PubMed:11722764).  In response to SA signaling, triggers the accumulation of FLS2 at the plasma membrane, thus priming defenses (PubMed:24923602).  Involved in SA-dependent freezing signaling and tolerance (PubMed:19959255).
What are the official names of this protein?
Protein ACCELERATED CELL DEATH 6.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Constitutively undergoes endoplasmic reticulum-associated degradation (ERAD), via ubiquitination and subsequent degradation by the proteasome. During salicylic acid (SA) signaling, the soluble pool decreases, whereas the plasma membrane pool increases.
Protein: DCUP_GLUDA
Sequence: MTDTGKPLLRVLQGEAVWPPPIWLMRQAGRYLPEFRALRDQADFITRCMTPDLATEITLQPIRRYAMDGAILFSDILILPWAMGQSLDFVAGKGPILGAIRSEADLARLDPKRVPDATAPVMETLSRLRAILDGPDPIGAAQGGRVTLLGFAGAPFTVACYMVEGHGSREFDATRGMAYSDPLLFDRLMATLTQATADMLVAQIDAGAEAVMLFDSWSGLLPPAQFRRHVIAPTRAIVQEIQARRPGVPVIGFPRLAGIMAAEYARETGLRVMALDTGADMAAMAGLLPPGMTVQGNLDPLLLLAGGDAMAQEARAIRDAMKGRPHVFNLGHGVVPPTPPEHVGDLVRTVREV
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSPE_DICDI
Sequence: MRFISIFLIIVALCVSSSWAFNFTDQPNSFRISGTGCGSGTTTVYFSTDGRCNSACGGSIRIKGEGNNVPNQQFTLNDYSKNVTNCSGTSNVASFRCPALVNTTSPTFTVNVGNSAYHVTCQYAQVTETPAGNSADKVAVGIAIIFGALISLLAL
What are the official names of this protein?
Prespore-specific protein E, Protein 1I.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: NACB_SCLS1
Sequence: MDMEKLKRMQARGGVRTGDGKGTPRRKVKNVHKSTGMDDKKLQTSLKKLNVQPIQAIEEVNMFKSDGNVIHFAAPKVHAAVPSNTFAIYGNGEDKELTELVPGILNQLGPDSLASLRKLAESYQSMQKAEGGEEKKDDEEDDDDIPDLVEGENFEDKVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: DISA_BACC2
Sequence: MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPEASIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYHQEKTQDHHQILKKLQDLANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATIHELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: PTPA_STAAM
Sequence: MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
What is the function of this protein?
Secreted tyrosine phosphatase that plays a critical role during infection as a bacterial effector protein that counteracts host defenses.  Required for intramacrophage survival.
What are the official names of this protein?
Low molecular weight protein-tyrosine-phosphatase PtpA, Phosphotyrosine phosphatase A, PTPase A.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted intracellularly upon bacterial infection of macrophages.
Protein: LETM1_HUMAN
Sequence: MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS
What is the function of this protein?
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18628306, PubMed:19797662, PubMed:24898248, PubMed:24344246, PubMed:29123128, PubMed:32139798, PubMed:36321428, PubMed:36055214).  Mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662, PubMed:24344246, PubMed:29123128).  Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:24898248, PubMed:36055214, PubMed:36321428).  Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306, PubMed:36055214).  Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306, PubMed:32139798).
What are the official names of this protein?
Mitochondrial proton/calcium exchanger protein, Electroneutral mitochondrial K(+)/H(+)exchanger, KHE, Leucine zipper-EF-hand-containing transmembrane protein 1.
What is the protein family that this protein belongs to?
Belongs to the LETM1 family.
Protein: URE2_HERA2
Sequence: MQPGEYLIDQPTEAIAANLGRATCELLVAHTGDRPIQVGSHYHFFEVNRALVFDRGLAYGMHLNIPAGTAVRFEPGDSKIINLVAFAGTRQIYGHNGLVNGALDAVDQRQTSLNAVQQQQFGHRAQGDLE
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PATN_ASPCL
Sequence: MVLATSLKGAHVLITGGTRGMGEAMVHQFLQEEANVSYCARTVTNTEFDEFYKTLPEGNTARAVGTAFNVASKEAIVDWVKSSAERLGRIDVIIANASPMHMEGETEHWVESFAIDVMGFVELVRAATPYLEQSPQASIIVQSSFMGREFYRSPPAAYGPCKAAQLQHVQELSHYLGPKGIRVNAISPGPILCKGGPWEKYSTLMPEWVEEQRLKIPLKRLGGPTEVANVAVFLASPLASFVTGTNVLVDGGIHVGTQF
What is the function of this protein?
Isoepoxydon dehydrogenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (By similarity).  PatN catalyzes the conversion of isoepoxydon into phyllostine (By similarity).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units.  The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol).  These first reactions occur in the cytosol.  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI.  The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole.  PatN catalyzes then the transformation of isoepoxydon into phyllostine.  The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol.  The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM.  Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (PubMed:19383676) (Probable).
What are the official names of this protein?
Isoepoxydon dehydrogenase patN, IDH, Patulin synthesis protein N.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RECF_BRUA2
Sequence: MEAKDHIERRPDRVSIRRLKLVNFRNYAELSLPLGPGHVVLTGENGSGKTNLIEAISFLSPGRGLRRAAYDDVARANAEGGFAIHAALDCMIYGDAEIGTGTAGGGEGGRKVRINRIAASADDLLDYARILWVVPSMDGLFTGGASDRRRFLDRMVLAIDTAHGKRVLDYEKAMRSRNRLLNDGSNDDQWLDAIENQMAELGTAIAAARAQAMRLIAAMIERLPAEGPFPKADCFLEGALESRIGVEAALDLEEDFRRTLRDGRARDRAAGRTLDGPHRTDLIVQHRPKSMPAALCSTGEQKALLIGLILAHARLTAELSGMAPILLLDEIAAHLDMGRRAALFGILDELGGQAFMTGTDRALFDALAGDAQFFNVSAGQLTGI
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASPD_HPVKA
Sequence: MALSFKNSSGSIKAKRIKDGLVNANDIETTVIDFSYEKPDLSSVDGFSLKSLLSSDGWHIVVAYQCVTNSEQLNNNKKNNKTQKFRLFTFDIIVIPGLKPNKSKNVVSYNRFMALCIGMICYHKKWKVFNWTRKSYEDNTSTIDFNEDEDFMNKLAMSAGFSKEHKYHWFYSTGFEYTFDIFPAEVIAMSLFRWSHRVELKIKYTHESDLVEPMVRQLTKKGTISDVMDIIGKSTIAKRYEEIVKDRSSTGIGTKYNDVLDEFKEIIKKINSSSLDSTIKDCLKDIEE
What are the official names of this protein?
Capsid protein, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the high plain virus capsid family.
What are the subcellular locations of this protein?
Virion.
Protein: IHFA_SHELP
Sequence: MALTKAEMAEHLFETLGINKRVAKEMVEAFFEEIRQALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPISARRVVTFRPGQKLKSRVEEANAGK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.