PharMolix/UniProtQA huggingface dataset:
Protein: NUSB_STAAW
Sequence: MSRKESRVQAFQTLFQLEMKDSDLTINEAISFIKDDNPDLDFEFIHWLVSGVKDHEPVLDETISPYLKDWTIARLLKTDRIILRMATYEILHSDTPAKVVMNEAVELTKQFSDDDHYKFINGVLSNIKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: Y028_YERPE
Sequence: MASFRRFRLLSPLKPCVTFGRMLYTRIDKDGLTMLAGHLAYVSLLSLVPLITVIFALFAAFPMFAEISIKLKAFIFANFMPATGDIIQNYLEQFVANSNRMTVVGTCGLIVTALLLIYSVDSVLNIIWRSKIQRSLVFSFAVYWMVLTLGPILVGASMVISSYLLSLHWLAHARVDSMIDEILRVFPLLISWVSFWLLYSVVPTVRVPARDALIGALVAALLFELGKKGFAMYITLFPSYQLIYGVLAVIPILFLWVYWSWCIVLLGAEITVTLGEYRAERHHAKSVTTQSPEM
What are the official names of this protein?
UPF0761 membrane protein YPO0028/y3801/YP_0029.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPDLB_XENLA
Sequence: MEESETVLKLRRQLKEAEEERVKAAHYGLELLESQSDLQNQLEEQRNEMTGTIENLEQEKYSLQREVELKNRMLESLTSECENIRQQQKLSLEQLEEQLERNHHRELSEIKDKLEKLKAELDEARLSEKQLKHKLDYQTEVLANKSEELRMMSERVHETMSSEMLTLQLEKTELETAKDNLEQELNELQYREQQLLLTNGNQSRQLERLQTEKEEREKEAVGYFSALEKAREANQDLQAQLDIALQQAQDPNSKGNSLFAEVEDRRSEMERQLISMKVQFQSLQKQHAFSRQQMHRMKIQIATLLQLKGSHSDPEQLERLQAMVAQKNSEIETLVMKVRQLEKSQQICENGPVASSCDGLGQGDETYYVDLLKMKLVNSSKEIDKVKDELSLQRMKALAESQRVLELERKLFTNDRHLKLSQGENMKLRVNLDEMKMKYEPDEMGKIRTQKRRKEQLPLDCLIDNTSVAVTSGTEAHGVSDATPGETCTAESSDDKKLPKEDLSLSTKDQDPSSVLLKPNEPPNGQPPKERKRVRIMEDEKDTPDLNKRNPNNCTITSIHPRSTYEESTSELKKVDEEQEKRKQERKSRLRAPPVLHVPSKPATAQCPQQ
What is the function of this protein?
Required for the localization of dynein and dynactin to the mitotic kintochore.  Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
What are the official names of this protein?
Protein Spindly-B, Coiled-coil domain-containing protein 99-B, Spindle apparatus coiled-coil domain-containing protein 1-B.
What is the protein family that this protein belongs to?
Belongs to the Spindly family.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore.
Protein: RL25_METEP
Sequence: MSATKTLEAVARDRVGKGAARAVRRQGQIPAVIYGGNQAPQAIAIDLIRARTLIYAGGFKTTVFEIDAGGKKTRAIPRDYQLDPVSGVPLHVDFLRVVAGQTVTVDVPVHFVNEDQAPGIKQKGGTLNVALHTLSLEVAPDQIPDAIEVDLAGREIGDVIHASDLRLPAGTYTGEPTDTVANLLPPTVLGADVEAEEAAVAEAQSAESAEGKAEAEAEATNEKNKSEA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: HVM13_MOUSE
Sequence: EVQLQQSGPELVKPGASVKMSCKASGYTFTDYYMKWVKQSHGKSLEWIGDINPNNGGTSYNQKFKGKATLTVDKSSSTAYMQLNSLTSEDSAVYYCARDRYWYFDVWGAGTTVTVSS
What are the official names of this protein?
Ig heavy chain V region J558.
Protein: ENO_METEP
Sequence: MTAITNIAAREILDSRGNPTVEVDVLLEDGSFGRAAVPSGASTGAHEAVELRDGDKSRYNGKGVLKAVDAVQSEILDAIGGMDAEDQVAVDEAMIALDGTPNKARLGANAILGVSLAVAKAAAETAGLPLYRYVGGVQGRVLPVPMMNIVNGGAHADNPIDFQEFMVMPVGATSLSDAVRMGAEIFHTLKSALKKAGHNTNVGDEGGFAPNLPSAEAALDFVMESINAAGFKPGSDVVLALDCAATEFFKDGAYRYEGEGQTRSIEQQVDYLAKLTEAYPILSIEDGMSEDDWEGWKLLTDRIGSRVQLVGDDLFVTNVERLARGIETGTANSILVKVNQIGSLTETLAAVDMAQRAGYTAVMSHRSGETEDSTIADLAVATNCGQIKTGSLARSDRLAKYNQLIRIEEGLGAQALYAGRSAIRQLAGR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PYRR_PSEA8
Sequence: MSLPNPAELLPRMASDLRAHLAERGIERPRFVGIHTGGIWVAEALLRELGNQEPLGTLDVSFYRDDFTQNGLHPQVRPSALPFEIDGQHLVLVDDVLMSGRTIRAALNELFDYGRPASVTLVCLLDLNARELPIRPDVVGQTLSLGRDERVKLVGPAPLALERKVLSSAS
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: YBOX1_RAT
Sequence: MSSEAETQQPPAAPAAALSAADTKPGSTGSGAGSGGPGGLTSAAPAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNYQNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYARRPQYSNPPVQGEVMEGADNQGAGEQGRPVRQNMYRGYRPRFRRGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE
What is the function of this protein?
DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation.  Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C).  Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay.  Component of the CRD-mediated complex that promotes MYC mRNA stability (By similarity).  Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity).  Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs.  Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs.  Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs.  Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection.  Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'.  Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes.  Promotes separation of DNA strands that contain mismatches or are modified by cisplatin.  Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair.  The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity).
What are the official names of this protein?
Y-box-binding protein 1, YB-1, Enhancer factor I subunit A, EFI-A, Nuclease-sensitive element-binding protein 1, Y-box transcription factor.
What is the protein family that this protein belongs to?
Belongs to the YBX1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Secreted, extracellular exosome. Note=Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges.
Protein: HEM1_ECOUT
Sequence: MTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLARQIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERLREADIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVEAETIVAQEASEFMAWLRAQSASETIRDYRSQAEQVRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDSLGLE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: PDXJ_TRIV2
Sequence: MATLGVNIDHIATIRQARRTVEPDPVAAAVLAELGGADGITVHLREDRRHIQDRDVQLLRQTVRTHLNLEMAATDEMVGIALDIKPDYVTLVPEKREEVTTEGGLDIVGQIARIGEVVSKLQNAAIPVSLFIDAEPAQIEASVKVQAKFIELHTGRYAEATDETSRQQELAFLATGCEQAIKAGLRVNAGHGLTYWNVYPVAALPGMEELNIGHTIISRAALVGIERAVREMKQAIRGE
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_SORC5
Sequence: MFRGRVRHVHFVGIGGVGMSGLAEILRSLEFEVSGSDLKESSTTRRLTSLGVRIDIGHRAENVRGVDVVVYSSAIRPENPELTEARALGTPVIGRAEMLAELMRVKYGVAIAGSHGKTTTTSLVATVLRAAGLDPTVVVGGKMAALGTNARLGAGDLLVAEADESDGSFLRLTPTIAVVTNIDPEHLDHYGTHERIKDAFVEFAARVPFYGLAVLCLDHPHVQDLLPRIPRRHVTYGVSPQSDYSARGIQFRGLETSFNAYRRGEPLGGFTVKMPGAHNVLNCLATIAVADELEVPLDVTKQALATFGGVARRFTVVGSIGGVTMIDDYGHHPAEIRATIDAARRAFPGEDHRVVVAFQPHRHTRTRDLFDEFTRAFNQADVLLVTDIYAAGEPPIPGVTAERLVQSIREHGHHDARFIADKTDLPEALEKIARPGDVVIALGAGDVNACVRGLKARLEAKSPPQEGSS
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPNP_DELAS
Sequence: MTTETISGITLTTKANVYFDGKCISHGFTLADGTKKSAGVVLPSQLTFGTAAAEIMECVAGSCEYKLDGSDQWLTSKAGESFQVPANSKFDIRVTEAYHYICHYA
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: HVM18_MOUSE
Sequence: EVKLVESGGGLVQPGGSLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIAASRNKANDYTTEYSASVKGRFIVSRDTSQSILYLQMNALRAEDTAIYYCARDYYGSSYWYFDVWGAGTTVTVSS
What are the official names of this protein?
Ig heavy chain V regions TEPC 15/S107/HPCM1/HPCM2/HPCM3.
Protein: RGI1_CLAL4
Sequence: MTKGKKKQTVELDLNKVEKLEHLMPVPKSRQSSITSVESEDGSLKEVLKPPPRKDFEDLASFESYIRDETWDNEFDYCHAHLTYYPPFVLKEVHDDIEKIKPTMNKNSSKFRRNLQHHIQRHLILEMEKCCGFEMDFGKAKMEETPKNIIWRYEDSGDHGFPKEEEDKFNRHWKLELEVSCNNENPLVQVDYKAIPV
What is the function of this protein?
Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
What are the official names of this protein?
Respiratory growth induced protein 1.
What is the protein family that this protein belongs to?
Belongs to the RGI1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KCD12_MOUSE
Sequence: MALADSARGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQVYVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFFFRYILDYLRDLQLVLPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVHKEGSLGDELLPLGYAEPEPQEGASAGAPSPTLELASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRGSYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKFNFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE
What is the function of this protein?
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response.  Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD12, Pfetin, Predominantly fetal expressed T1 domain.
What are the subcellular locations of this protein?
Presynaptic cell membrane. Postsynaptic cell membrane. Note=Colocalizes with GABRB1.
Protein: GMM_ECOLI
Sequence: MFLRQEDFATVVRSTPLVSLDFIVENSRGEFLLGKRTNRPAQGYWFVPGGRVQKDETLEAAFERLTMAELGLRLPITAGQFYGVWQHFYDDNFSGTDFTTHYVVLGFRFRVSEEELLLPDEQHDDYRWLTSDALLASDNVHANSRAYFLAEKRTGVPGL
What is the function of this protein?
Hydrolyzes both GDP-mannose and GDP-glucose (PubMed:7592609, PubMed:10913267, PubMed:23481913).  Could participate in the regulation of cell wall biosynthesis by influencing the concentration of GDP-mannose or GDP-glucose in the cell.  Might also be involved in the biosynthesis of the slime polysaccharide colanic acid (PubMed:7592609, PubMed:10913267).
What are the official names of this protein?
GDP-mannose mannosyl hydrolase, GDPMH, Colanic acid biosynthesis protein WcaH.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: HIS6_PETMO
Sequence: MLTKRIVAALDIKEGRVVKGVQFENIRDAGDPVELAKKYEKDGVDEIVFLDITASKEKRNILKNLVEEIAKELFIPFTVGGGLKTVEQMVEIIKCGADKVFINSAAVENPNLIKESSKIIGSSNVVVAIDAKKDVESEKYYVYTHGGSKKTDLDAVEWARKCQELGAGELLVTSMNTDGVKKGYDLNLTKQIVDAVEIPVIASGGAGEVKDFIDVFQIGADAALAASIFHYGIYTAKDLKIQLKKVGINVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_DICTD
Sequence: MAHILMKQLLEAGVHFGHQTKRWCPKMKEYIFSERNGIHIIDLQKTLVKLEEAYEFAKEQAKEGKTFLFVGTKKQAQQTIEEEAKRCGAFYVNQRWLGGMLTNFTTIKSRIDYMIKLEELKNNGYFDKLPKKQANRLNRELEKLIKVFDGLRGIERIPDVLYIVDPKREEIAVKEANKLGIPIIAIVDTNCDPELITYPIPGNDDAIRSIKLITSKIADAILEGRDLREKEADLQLKDEDLQSEIS
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: LMBD1_XENLA
Sequence: MATGSTELLIGWCIFGVLLLAILAFCWVYVRKYQSHQESEVISTITAISSLAIALITSALLPVDIFLVSFMKNHNGTFKDWAENNDTRIQIENTVLIGYYTLYSIILFCVFLWIPFVYFYYEEKDDTDGSHCSQIGSALKYTSGFVLVCSCLLLIGAFAPLDIPSKANATELDKIKLLFQNLGSSNGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGKRNAHYERLENSEDIEEVEQQVENIKSKCKDGRPLSSKDRQALYKLQEKLRTLKRKDRHLEHHENNCWTKCCLVMRPFKIVWGILFILVALLFIVSLFLSNLDKALHSAGINTGFIIFGTNLTNPLNILLPVLQTVFPLDYIFITTITMYFIFTSMAGIRNMGIWFFWIRLYKIRRRRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQKYLWENNSTQETAIGNSSALVLKDCDASAPEDQCTVTRTYLFLHKFWFFSSIYYFGNWAFIVVFVIGLIVSCCKGKKSVIEGEVEDDDSDLSDDEDHP
What is the function of this protein?
Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors.  Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome.  Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity).  May play a role in mediating and regulating the internalization of the insulin receptor (By similarity).
What are the official names of this protein?
Lysosomal cobalamin transport escort protein LMBD1, LMBD1, LMBR1 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the LIMR family. LMBRD1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: MVP_BTMV
Sequence: MATMMHFGQFPSNIPLRAATCCTKVHSTLVTKEMMASSVKPAESSSVARPIIYSSAATDGYEKAQRAFEASFREKYSGKLEAMKYGKMVKKGGLTYVKRAGPQAIAKGIEMDAAIEKFNTAFNAGELENVTLEGDITAGISVARGESVWLRSVFWSRSLKKQARKKTPKLVAKSDFDDLFNKVLKVASLGNIPVEIVGKKANKILRCGYRRVNTSTIPYFHLPHHNSNYICRELHPQRVRWLVPLLVRHRKIRDQFSDSMIARGWSGLILPKYIASTCGRRYDEVIVRGRLYGRVEDARTKLPAGDVGRTMHYSSGEERFFAGWKEGFEKLVPAQKEHICKIVQDNKFCGKLAASIVQIAFPCHKMACDVCRNKFNEMTPEAYSELIDKHIDQRMNEINEAIVRFPGLKQVVSNFRSKHIASTNIKDNLEVAKLTQGHKANQMMQLARINSILIKGNTATPSEISDASGLLLEITRWFNNHLSVIDKGSLRAFRNKRSSKALVNPSLLCDNQRDKNGNFIWGERGYHSKRFFASHFDEVTPGDGYKEYIIRKGPQGQRKLAIGNLIVSFDLEKTRQALKGEEVEKLPLSNSCVSKRNGNYVYTSCCVTLDDGTPLYSNIKNPTKRHLVVGTTGDPKIVDLPATDTDKMYIAKEGYCYLNIFLAMLINVNENEAKAFTKMVRDIIIPMLGTWPTMQDLATACFMMTAFFPETSSAELPRILVDHTNQTMHVIDSFGSLTTGYHVLKAGTAAQLIDFASTELEGEMKWYRVGGHGLPVKEKMISALITSIFRPKKLVYLIEEDPYVLIMAMCSPRLIISLFNNGALELAAKHWISRDKNVSAIFAMLMDLSTEMSKAELLIEQHRMINECAKRVHDTQNYLDEVGPHQQEVRTFLALISDELEADKELHKTGFANFSERFHSLTEKNVCGRVRRGMARFKLVRQILLCHLCVQAQTAFNIRFAPEKVRRYRCQIRHIAQLVRWKDEGTPKWRPEVCYKPDHPIHELHQARYARQSHAHHVQLPKGPRILYECCLGDSFAH
What is the function of this protein?
Allows efficient cell to cell propagation, by bypassing the host cell wall barrier.  Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding (By similarity).
What are the official names of this protein?
P3N-PIPO polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae P3N-PIPO polyprotein family.
What are the subcellular locations of this protein?
Host cell junction, host plasmodesma.
Protein: TRBP2_MOUSE
Sequence: MSEEDQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSLLDSSPPEDTPVVAAEAAAPVPSAVLTRSPPMEMQPPVSPQQSECNPVGALQELVVQKGWRLPEYMVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEAEPDDDHFSIGVSSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSVGSLGALGSACCSVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCYGSATTREAARGDAAHRALQYLRIMAGSK
What is the function of this protein?
Required for formation of the RNA induced silencing complex (RISC).  Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2.  Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2.  AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2.  May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity).  Binds in vitro to the PRM1 3'-UTR.  Seems to act as a repressor of translation (PubMed:8649414).
What are the official names of this protein?
RISC-loading complex subunit TARBP2, Protamine-1 RNA-binding protein, PRM-1 RNA-binding protein, TAR RNA-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the TARBP2 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Protein: HIS6_XANCP
Sequence: MLSRRIIPCLDVRDGRVVKGVKFRDHIDMGDIVELAMRYRDQGADELVFYDIGASPEGRSVDYAWVERVARLIDIPFCVAGGIRDVETARAVLHAGADKISINSPALGRPQLISELADAFGVQCVVVGIDSIREEDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQRLGAGEIVLNCMDNDGVRHGYDIAQLRQVRALCRVPLIASGGAGEMQHFADVFDQADADGALAASVFHSGAIPIPELKRFLRAQQIEVRDGQ
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_THEKO
Sequence: MEGLSFGPLSILPSLAEELNPHRVAFLTNTTVERLWLEKAAEGIEEPIRIVIPDGEKYKSLETAVAIWKRLQEEGFTRKSLLIGLGGGVVTDIAGFVASTYMRGTLLGLVPTTLLAQVDAAIGGKTGVNFNGKNMIGTFYLPNFVLIAHETLSTLPEEEIRNGLGEVAKYALLDRKVYALARNFEGISETLIRECALFKVEVVEKDLGESGLRRILNLGHTAGHAIEKLSNYRIKHGLAVSMGLMVASKVGEELYGFDSGKTEELLKKLGLPTGHPFRAEEILEEMRLDKKAWYGRITFVIPVEIGDVVVEEVDEAVLKRALEATRDDSGSGDCQKPGGSA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_RHOBA
Sequence: MALMPKRVKHRKSQRGRIKGNATRGNTVVFGDYGIQSLDAGWIKATTIEAGRIAAQQYVRGQGKLYIRIFPDKSVTSTPLETRMGKGKGEPDFWAAVVKPGTILYELSGVTEQQAKVCFARLASKMPVKVRFVERRSA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: DPHB_THEAC
Sequence: MLNIIGVGLRGTGSITFDEFDALRTSDFVYADMYTSIGQPGLIRKISAMIDRDILPLTRDEIENGSILPQAASKNVSLIVVGDPLMATTHNELRYEAMNQGIGVRIFENASILNAAIGKAGLMVYKVAPPVSLPRISEKFFPLSVIDKIKRNADLGLHTPVLIDLEDQENIPLHDALASLLEMERRREYSGIIREICVLSRISFPDEKILFGRIEDMMQQEVNSPYMMFILSKLDDNERRFLSLFSESVSKVSDARS
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: Y2328_VIBPA
Sequence: MKLWVDADACPKVIRETIVRAAERTGVECTFVANHVVPVPKRANIHSLQVPAGFDIADNEIVRRVEPNDLVITSDIPLADEVITKGALALSSRGELYTKDTIKARLNIRDFMETMRSSGIQTGGPAALSQTERREFANHLDRILAKR
What are the official names of this protein?
UPF0178 protein VP2328.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: DLDH_MYCGE
Sequence: MDYDLIILGAGPAGYIAAEYAGKHKLKTLVIEKQYFGGVCLNVGCIPTKTLLKRAKIIDYLVHAKDYGITINGQAKLDWKQLLKQKQEVVDKLVAGVKTIIKGAKVESIEGEATVIDKNKVQVNNTTYTTNNIIVATGSRPRYLTLPGFEKAQQAGFIIDSTQALALEGVPKKFVVVGGGVIGVEFAFLFASLGSEVTIIQGVDRILEVCDSDVSELISKTLKNKGVQIITNAHVVRAENNQLFYTVNGVEQSVIGDKILVSIGRIANTECLDQLDLKRDHNNKIVLNEKLQTSTTNIYLIGDVNTQMMLAHYAYQQGRYAVDQILNQNQVKPAEKNKCPACIYTNPEVAFVGYSEMELQKEKIDYVKSSLPFIYSGKAIADHETNGFVKMMFNPKTGAILGGCIIASTASDIIAELALVMENNLTVFDIANSISPHPTMNEMVTDVCKKAIFDYFS
What is the function of this protein?
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.
What are the official names of this protein?
Dihydrolipoyl dehydrogenase, Dihydrolipoamide dehydrogenase, E3 component of pyruvate complex.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.