PharMolix/UniProtQA huggingface dataset:
Protein: RAG2_MOUSE
Sequence: MSLQMVTVGHNIALIQPGFSLMNFDGQVFFFGQKGWPKRSCPTGVFHFDIKQNHLKLKPAIFSKDSCYLPPLRYPATCSYKGSIDSDKHQYIIHGGKTPNNELSDKIYIMSVACKNNKKVTFRCTEKDLVGDVPEPRYGHSIDVVYSRGKSMGVLFGGRSYMPSTQRTTEKWNSVADCLPHVFLIDFEFGCATSYILPELQDGLSFHVSIARNDTVYILGGHSLASNIRPANLYRIRVDLPLGTPAVNCTVLPGGISVSSAILTQTNNDEFVIVGGYQLENQKRMVCSLVSLGDNTIEISEMETPDWTSDIKHSKIWFGSNMGNGTIFLGIPGDNKQAMSEAFYFYTLRCSEEDLSEDQKIVSNSQTSTEDPGDSTPFEDSEEFCFSAEATSFDGDDEFDTYNEDDEDDESVTGYWITCCPTCDVDINTWVPFYSTELNKPAMIYCSHGDGHWVHAQCMDLEERTLIHLSEGSNKYYCNEHVQIARALQTPKRNPPLQKPPMKSLHKKGSGKVLTPAKKSFLRRLFD
What is the function of this protein?
Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination.  V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments.  DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.  The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps.  The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes.  The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele.  In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1.  It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3.
What are the official names of this protein?
V(D)J recombination-activating protein 2, RAG-2.
What is the protein family that this protein belongs to?
Belongs to the RAG2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TDCC_ECO55
Sequence: MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEKDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF
What is the function of this protein?
Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system).
What are the official names of this protein?
Threonine/serine transporter TdcC, H(+)/threonine-serine symporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DPCKG_HALMA
Sequence: MSDVVLELPSDLRHELKEPLGRIYTDTAALLADAGDPIIAVGDMVTYHLIEAGRTPDLALVDERTERSAVDADVAAAIDGFDRTLSVDNPAATLTADLLAALRDGLDSDETTLLDVDGEEDLATLPAVLAAPAGASVVYGQPDEGMVLADCDDTARDRVRSLLERMDGDAERAIALVSN
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.
Protein: PORA_PYRAB
Sequence: MPIRTVMKANEAAAWAAKLAKPKVIAAFPITPSTLVPEKISEFVANGELDAEFIKVESEHSAISALVGASAAGVRTFTATASQGLALMHEVLFIAAGMRLPIVMAIGNRALSAPINIWNDWQDTISQRDTGWIQFYAENNQEALDLILLAYKVAEDERVLLPAMVGFDAFILTHTVEPVEIPDQEVVDEFLGEYEPKHAYLDPKRPITQGTLAFPAHYMEARYLVWEAMENARKVIDEAFAEFEKKFGRKYQKIEEYRTDDAEIIFVTMGSLAGTLKDWVDKKREEGYKVGAAKMTVYRPFPVEEIRELAKKTKVLAFIEKDISMGLYGAVFTDASAALINESEKPLMLDFIAGLGGRDVTFNQLDEALSIAKEALEKGKVEKPIHWIGLRKELL
What are the official names of this protein?
Pyruvate synthase subunit PorA, Pyruvate oxidoreductase alpha chain, POR, Pyruvic-ferredoxin oxidoreductase subunit alpha.
Protein: BRK1_HUMAN
Sequence: MAGQEDPVQREIHQDWANREYIEIITSSIKKIADFLNSFDMSCRSRLATLNEKLTALERRIEYIEARVTKGETLT
What is the function of this protein?
Involved in regulation of actin and microtubule organization.  Part of a WAVE complex that activates the Arp2/3 complex.  As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
What are the official names of this protein?
Protein BRICK1, BRK1.
What is the protein family that this protein belongs to?
Belongs to the BRK1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ERA_UREP2
Sequence: MIKKYGIVAIVGKPNVGKSTLINAIMKKKVSIISNKPQTTRNAVKEIYEDDESAIIFTDTPGFHEPSNKLDLFLNHEIEISYKEANVILFVTTMDKELDANDFEIINLIKEANKENIILVISKAEMAKNQDQIDERIHFLKKHIAFKDVVQISALHVINIDKLINTIKNYLHKDVVTDYFRQKAEKEDKFVITEIIREQCLLNLNHEVPHGVGVEIDESKYNQEANHWIIKASIIIEKNSHKPIIIGQNGTMIKKISMGARKQLHEIYDCHISLTIFVKVENNWRDNNNIIKSLGYKIKK
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: AMPA_BACCZ
Sequence: MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTDVKRYYFVGLGKKESYTTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDAQEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKMIALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEASMETDESIWQLPIFDRDKERVRNSKFADLNNSPGREGHAVMAGTFLGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAMVRTLATLVERFGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_PSEE4
Sequence: MKAFTQHIGLVAPLDRANVDTDQIIPKQFLKSIKRTGFGPNLFDEWRYLDVGQPYQDNSKRPLNQDFVLNHARYQGASVLLARENFGCGSSREHAPWALDEYGFRSVIAPSFADIFFNNSFKNGLLPIILDAAEVDELFKQVEATPGYQLTIDLEAQAVTRPDGKVLKFEIDAFRKHCLLNGLDDIGLTLQDSDAIKAFEGKHRASQPWLFRDA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: NUOK_LEGPH
Sequence: MIPVYDYLVLGVILFGLSLVGIMLNRKNIILLLVCVELMLLAVNTNFIAFSHYYNEVGGQVFVFFILTVAAAEAAIGLAIVMLLYRNRGNIDVDKMNHLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LACB_STRPI
Sequence: MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPIFGKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNANVIGFGGKITGELLMCDIIEAFIHAEYKPSEENKKLIAKIEHLESHNAQQTDANFFTEFLEKWDRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: TCTP_DROYA
Sequence: MKIYKDIITGDEMFADTYKMKLVDEVIYEVYGKLITRQGDDIKLEGANASAEEADEGTDITSESGVDVVLNHRLQECFAFGDKKSYTLYLKDYMKKVLAKLEEKSPDQVDVFKTNMNKAMKDILGRFKELQFFTGESMDCDGMVALVEYREINGDSVPVLMFFKHGLDEEKC
What is the function of this protein?
Involved in calcium binding and microtubule stabilization.
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_XANOP
Sequence: MSTIEERVKKIVVEQLGVKEEEVTTSASFVDDLGADSLDTVELVMALEEEFECEIPDEEAEKITSVQQAIDYVKSHVKS
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRWD1_MOUSE
Sequence: MAEPSPARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEVPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGPPPSLVEIHRGRQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTLIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGPQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFDAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMSARISGDTSSEEERFMKPKVTMIAWNQDDSTVVTAVNDHVLKVWSSYTGQLLHNLLGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGIKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENSADEHLVPQLGYVATSDGEVIEQIISLHTNDSGDASPESSVLDGMIRQLQQQQDQRLGVDQDGTANGLPSGEGTPRRGSFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEAPPGMFRRLEDIRIERGEEERNLYVIGRKKKTFQVPQKSNSMVLVSQSRQRTCRRKYANYSRRNADQCELSSGNESSGSVRHETSYDQSEGSCSSEDDEWRNDRRSGSDSDSSSDSSSQYSDWTADTGINLQPPLRMSCRRRVTRFCSTSEDEMSMENISPPKRRRKRRKESKPKRESLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQMGDEVMYFRQGHEAYIEAVRRNNIYELNPHKEPWRKMDLRDQELVKIVGLRYEVGPPTLCCLKLAFIDPATGRLTDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQPCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTETEKLSPWDMEPIPDNVDPPEELGASISVTSDELEKLLYKPQEGEWGQRSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALIWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQDCTNISELCNTSDNDEDDSADDLDDSDLPKTSSGRRKVHNWKRRSRASGCIESDWRRQCKALLILIFQCEDSEPFRQPVDLDEYPDYRDIIDTPMDFGTVRETLEAGNYDSPVEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISFDFKIGQKFKEKLRRSQRFKQRQNCNGAVPGDRRRRNVKQKQFKSQTKVIPQLMCPPSQSTSSKVPLSATRKTSAGVSSGFTSGDSSDSAGSLERVRRQRPEVLRSGSVLFGSEMEDFLATSSSSSASNSSEESKASPGARESSLRSGVLRGSNLGVTRTRAARRKAGSVSLENGCGRKATRKRVYLSDSDNNSVETDENLKNRKCGSSRKVLRKCAAVAASKIKLMSDAEDSSSESPCSGRKLPHRNASAVARKKLLHNSDDQSLKSETEELKDQNQSLLISGPHSVHNSISDSESDSDLRATRKTWNANGCTSHTAATCKTKSRPIESSEEDSRCHGSDHGPSSTGDPSTSGQKLRADSISEEADSEPESSVLCKNTHLCKKAKILSDSEDCEEKCGERRGPEVEGSPVSEALREAILAPQCLSHRGSETDVDSDGGAVREKSYSNENGSVSLENGQRRKVSRKSSSDKESNLQVTQKSPKDRSSPSRITQRASVATDKMKLTSDAEDLSLESVCTRSKRRRKKPARFACTPAKTALSSEEKHAHCEVPEAQPACRNKLPEPEHQDSAENPSQAASADLNSGGGSSFEQRKSIQSRQMGAVCVRPPPKTQSSSAGLSQENARSQTLDSETSLPSESVLTQKATVESNFEEELNYGLRRWNGRRLRTYGKAPLSRTAQVTPSLQASAEVGVKRRRMHPEVDGEDVPGQMGSSGCGPDTSPKASDLGSVTDSDVDCTDNTQTQRKKKRKGKARVLSKESVRKDREPHTKMRPCMLNEKDAVQMHSDTLKAKTVPEKVPRRCATVAANKIKMMCNLKEVVSGPENVGIRTISRKLPYRQASAAAKKKLLSVYKEDDAPIHSENEKELYLRRFRSRKEKAQPTPR
What is the function of this protein?
May be a transcriptional activator.  May be involved in chromatin remodeling.  Plays a role in the regulation of cell morphology and cytoskeletal organization.  Required in the control of cell shape.
What are the official names of this protein?
Bromodomain and WD repeat-containing protein 1, WD repeat-containing protein 9.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y1679_GLUOX
Sequence: MAGHSQFKNIMHRKGAQDAKRAKQFAKVLREITVATRSGLPDPTSNPRLRAAISMAREVNMPKDNVERAIKKASGAAGGDDYVEVRYEGYGPAGVAIIVEGLTDNRNRTAGEVRAAFSKHGGSLGETNSVSFMFQRLGVISYPLDVASEDEMLEAAIEAGADNAETTEEGHEVTCAMENFFAVRDALESRFGEPQSAKLDWRPENSVTLDEDKARSVMKLIDVLEDSDDIQAVYANFDIPDDVAEALAA
What are the official names of this protein?
Probable transcriptional regulatory protein GOX1679.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_METRJ
Sequence: MANVVVVGAQWGDEGKGKIVDWLSEQADIVVRFQGGHNAGHTLVIDGVTYKLALLPSGVVRGGKLSVIGNGVVVDPWHLIDEIERIKAQGVDVSPSSLRIADNATLILPLHRELDHFRETANAGLKIGTTKRGIGPAYEDKVGRRAIRVVDLADPDALPAKIERVLTHHNALRRGLGIDEVNAEALLSELKAIAPKILPFADTVWSLLDEERRAGKRILFEGAQGALLDVDHGTYPFVTSSNIVAAQAATGSGLGPGAIGYVLGIAKAYTTRVGEGPFPTELFDEIGETIGSRGREFGVNTGRKRRCGWFDAVLVRQTVRTSGIHGIALTKLDILDGFEEIRVCTGYMLDGQPVDHLPASQAAQARIEPVYEVIPGWSETTAGARSWADLPAQAIKYVRRIEELIGAPVALLSTSPERDDTILMHNPFED
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCF_CANLF
Sequence: MKKTQTWIITCIYLQLLLFNPLVKTKGICGKRVTDDVKDVTKLVANLPKDYKIALKYVPGMDVLPSHCWISVMVEQLSVSLTDLLDKFSNISEGLSNYSIIDKLVKIVDDLVECTEGYSFENVKKAPKSPELRLFTPEEFFRIFNRSIDAFKDLETVASKSSECVVSSTLSPDKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKASNSIGDSNLQWAAMALPAFFSLVIGFAFGALYWKKKQPNLTRTVENIQINEEDNEISMLQEKEREFQEV
What is the function of this protein?
Stimulates the proliferation of mast cells.  Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture.  Mediates also cell-cell adhesion.  Acts synergistically with other cytokines, probably interleukins.
What are the official names of this protein?
Kit ligand, Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand.
What is the protein family that this protein belongs to?
Belongs to the SCF family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium. Cell projection, filopodium. SUBCELLULAR LOCATION: [Processed kit ligand]: Secreted. SUBCELLULAR LOCATION: [Soluble KIT ligand]: Secreted.
Protein: CCDC7_MACFA
Sequence: MKPVKHLLTTSNKSATLPALTSKKGLHNLPLSPKLKEKHNAKLIHDKIEPMVLRSPPTGESIVRYALPIPSSKTKNLLPGDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKRENEELSLSIGDDMNSFLTCCSQFATQLETALKEEQNVCILHYFFFCPSFVFLKWFQWQVNQMEEISKDQTLLQAEPPEPDKTVTLSIAQIVRLLQRFEELKNRLKQRSKSSWKVMLSKTMDEENRPEAVKSCEAVAQKIEEFIEAHSTDEFKGVSATEPQTAHSMTNRFNTMLKVFENQANMLERAVNDQVLLDAEYKQIQRDFELLSEEKLVLENELQKLKDTEKIKSTNNRTKKAAKTVKKKDKGKSEDSEKKMSSEKEFKIKDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLSQERKLLKSEGKTETTMRVGNSQTEVKGEDSKTIPLEKETGKSLVSDSGGQKTSDKIQEYPQITAQSGRLIEKSSEKKRSSPAISDLSQILKSQDESAFLESSNEVSVAENQSNKSPSETRDESLTTVSSSKEVQDSLSVGTLAQKNETVMSPFILPPVLTESKKADVSEEQLQKKTEEQTYQAPEKSQAYSEVPDENLMVENKDSVTKVQVEQMKQTTSSMERREATLTTPQSPEDVVLVSRSQSETKNLEATGNESFHSHNDVPEENLMLEQDTKSKTEVEVKKQKSFQDNQLNTHNEVPNERLIVEHQESMSKTKLQVKKQETSTEQPLTTHDKEPDENLTLGHQDSMSKSEMQVKEQSTLKGQRITTHEEEPGKNLALEHQDSLSKLEMQIKKNEKLPREKRHSTHGEESSENPMLKHQDAVSKIQVQLEKQETSEGGRSIPDKNSMFVHQDSVSKLQMQEKKKVTPGRERRNTHIVVPNENVVSVHQDSKSKLQMQEKKQINPGVEKHKTFPFEIQKKDISLEHLLPEEKVLLSRRESQTKKLQAKVTSRKITNEAASELPNTAENLPAVYPSISDLIIRLDLNKVVETDIESLRGALGRRLLNDEFKTQPKSFPGSEIEQLTDAFGRDILKDEFKTRSKSLPETDERLRRATERGTINNAMKTQLKRKSHPETGLKHLKGVNEKDIIKDLINIQSKRHAETDKEHLADAIGRGIIKGSINAQLKGHQETDKNFFAYAIGRGVRKESIKTQLKSHPETDKEFLADAIGRGIIIGPIIRQLKSHQETDKQLLKDAIGRDIIKGPINAQLKSHQETDVEPLTNAIGSSKTIGEIKTQLRTHYDVNLFKNKDMSIQRQEGIFNRSITPSKFPTKVINLSPFENKEETYEYSSPYAIAPSKAVYRTYRASSSFSKDIHLPLLNQLHSGHSKVVTLNQKTIEFTLPSVTNTIGKPAYKVLHAAARKSVPHPYF
What is the function of this protein?
May play a role in tumorigenesis.
What are the official names of this protein?
Coiled-coil domain-containing protein 7.
Protein: RUVB1_YARLI
Sequence: MVQINEIKSNSRDTRTAAHTHIRGLGLNEMGVAKPIDAGFVGQTEAREALGLVVDLIRASKMSGRGILLAGGPGTGKTALALAVSQELGPKVPFCPIVGSEIFSAEVKKTAALMENFRRAIGLRIKETKDIYEGEVTELTPEEAEDPLGGYGKTIRSVVVGLKSYRGTKQLRLDPKIYESIQKERVAVGDVIYIEANTGAVKRVGRSDAYATEFDLETEEYVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVMSMMGSLMKPKKTEITDKLREEVNKKVQSYIDQGVAELVPGVLFIDEVNMLDVECFTYLNRALESTISPIVILASNRGMCRVRGVDDDVSPHGITTDLLDRLLIVRTLPYSLDEIKTIIQKRAVVEQQQISEDALDALAQHGARTSLRYGLQLLSPAGVLAKSEGRDVVEVKDVEECESLFLDATRSKGRFTDKFL
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 1.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NCAP_CVM2
Sequence: MSFVPGQENAGSRSSSGNRAGNGILKKTTWADQTERGNRGRRNHPKQTATTQPNAGSVVPHYSWFSGITQFQKGKEFQFAQGQGVPIASGIPASEQKGYWYRHNRRSFKTPDGQHKQLLPRWYFYYLGTGPHAGAEYGDDIEGVVWVASQQADTKTTADVVERDPSSHEAIPTRFAPGTVLPQGFYVEGSGRSAPASRSGSRSQSRGPNNRARSSSNQRQPASAVKPDMAEEIAALVLAKLGKDAGQPKQVTKQSAKEVRQKILTKPRQKRTPNKQCPVQQCFGKRGPNQNFGGSEMLKLGTSDPQFPILAELAPTPSAFFFGSKLELVKKNSGGADEPTKDVYELQYSGAIRFDSTLPGFETIMKVLTENLNAYQDQAGSVDLVSPKPPRRGRRQAQEKKDEVDNVSVAKPKSLVQRNVSRELTPEDRSLLAQILDDGVVPDGLEDDSNV
What is the function of this protein?
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M.  Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NC, Protein N.
What is the protein family that this protein belongs to?
Belongs to the betacoronavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.
Protein: VKT11_CYRSC
Sequence: MGIARILSAVLFLSVLFVVTFPALLSADHHDGRIDTCRLPSDRGRCKASFERWYFNGRTCAKFIYGGCGGNGNKFPTQEACMKRCGKA
What is the function of this protein?
Serine protease inhibitor that inhibits trypsin and blocks voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type kappaPI-theraphotoxin-Hs1b, KappaPI-TRTX-Hs1b, Kunitz-type serine protease inhibitor huwentoxin-11g11, HW11g11.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 02 (native) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: O11H2_HUMAN
Sequence: MCPLTLHVTGLMNVSEPNSSFAFVNEFILQGFSCEWTIQIFLFSLFTTIYALTITGNGAIAFVLWCDRRLHTPMYMFLGNFSFLEIWYVSSTVPKMLVNFLSEKKNISFAGCFLQFYFFFSLGTSECLLLTVMAFDQYLAICRPLLYPNIMTGHLYAKLVILCWVCGFLWFLIPIVLISQKPFCGPNIIDHVVCDPGPLFALDCVSAPRIQLFCYTLSSLVIFGNFLFIIGSYTLVLKAVLGMPSSTGRHKAFSTCGSHLAVVSLCYSPLMVMYVSPGLGHSTGMQKIETLFYAMVTPLFNPLIYSLQNKEIKAALRKVLGSSNII
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 11H2, Olfactory receptor OR14-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CSPL8_SOYBN
Sequence: MASTDKHGDTEYRTSSSTPAPAGVDYFKFDVILRFVLFAASLVAVVVIVTGNQTEVILVPQPVPWPAKFRYTPAFVYFVAALSVTGLYSIITTLASLFASNKPALKTKLLPYFILWDALILGIIASATGTAGGVAYLGLKGNSHVVGWNKICHVYDKFCRHVGASIAVALFGSIVTVLLIWLSAYSIHSRVPK
What are the official names of this protein?
CASP-like protein 1D1, GmCASPL1D1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KGUA_ECOL5
Sequence: MAQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRQPRPGEVHGEHYFFVNHDEFKEMISRDAFLEHAEVFGNYYGTSREAIEQVLATGVDVFLDIDWQGAQQIRQKMPHARSIFILPPSKIELDRRLRGRGQDSEEVIAKRMAQAVAEMSHYAEYDYLIVNDDFDTALTDLKTIIRAERLRMSRQKQRHDALISKLLAD
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 125R_IIV3
Sequence: MQKSKSIFIPKAFAPQQQAQAPPSKLDNKDPSVEGEGASKPKDDEYLSENVLSHINSTIEKLVKPYEIFPSEDIRPDLFALVTALEAKMEDCIRRNGDTITGPLRLLTQPAANFDVTNKEYVDWIYSIVNTRLDSKWDRNADIDMNHFKIKNIQTPQELHDAATKAYVDEKVELINNLHTIPTHHLWSKATLVGKKTWFFHPGFICPQTLHLSAIGFSTSPNKYKIGEKTKFGELNPTRLYVVVNQEIRSEHVVEKDVQIGYILKRFETPIVLEEGCNFRLMTESCLPDASVNVSFY
What are the official names of this protein?
Uncharacterized protein 125R.
Protein: DRD2_PANTR
Sequence: MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
What is the function of this protein?
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity).  Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
What are the official names of this protein?
D(2) dopamine receptor, Dopamine D2 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: HAH4_HALMT
Sequence: MSKDRDGRRTSRRGTLKKIGGFSLGALSFGAVGRTQAATGSSVTTADIAPPGPNGDPKSVQIDDKYTGAEMYGEGDFRVGLGTDLTMYPPVYRESLGNGSGGWEFDFTVCGSTACRFVDSNGDVKEDDKAKEMWWQEINFNDINQDLYSRNDSDWVGSTPADTQPEFDYTEFALARDGVTLALTALNPAMGSLALGATYFLSDMVNWIASQHEDDSSLKRKWDYDGLSGPLYADSSTYLLARDEMTSNSYESFTIDNIAVAFPEFPVRTKYYVTFTAPDDPSTQSISTLEEEGIYRVPATEVAAARPPGSRRSKSAADEMVYVADPKKFIEVEPVKNPSIPDRIYEEIEQKKKQRSRKQ
What is the function of this protein?
Has antibacterial activity against other haloarchaeons.  Interacts with the membrane of the target cells where it causes permeability changes that result in an ionic imbalance leading to cell lysis and death.
What are the official names of this protein?
Halocin-H4.
What are the subcellular locations of this protein?
Secreted.