PharMolix/UniProtQA huggingface dataset:
Protein: EZRA_STRPI
Sequence: MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRVAENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSYEKTRETIRF
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: NOT2_YEAST
Sequence: MEKFGLKALVPLLKLEDKELSSTYDHSMTLGADLSSMLYSLGIPRDSQDHRVLDTFQSPWAETSRSEVEPRFFTPESFTNIPGVLQSTVTPPCFNSIQNDQQRVALFQDETLFFLFYKHPGTVIQELTYLELRKRNWRYHKTLKAWLTKDPMMEPIVSADGLSERGSYVFFDPQRWEKCQRDFLLFYNAIM
What is the function of this protein?
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.  NOT2 is required for the integrity of the complex.  The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes.  Preferentially affects TC-type TATA element-dependent transcription.  Could directly or indirectly inhibit component(s) of the general transcription machinery.
What are the official names of this protein?
General negative regulator of transcription subunit 2, cell division cycle protein 36.
What is the protein family that this protein belongs to?
Belongs to the CNOT2/3/5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYH_ENT38
Sequence: MAKNIQAIRGMNDYLPGETAIWQRIEGTLKQVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFNQLGVEVFGLQGPDIDAELIMLTARWWRELGISQHVALELNSIGSLEARANYRDALVAFLELHKDKLDEDCQRRMYSNPLRVLDSKNQDVQALLNDAPALGDYLDEESRDHFAGLCKLLEAAGIAYTVNQRLVRGLDYYNRTVFEWVTTSLGSQGTVCAGGRYDGLVEQLGGRAAPAVGFAMGLERLVLLVQAVNPEFKAESVVDIYLVASGADTQSAAMKFAERVRDALPGVKLMTNHGGGNFKKQFARADKWGASVALVLGESEVAAGEVVVKDLRSGEQTTVTQDGVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_AGARV
Sequence: MSKASVYEAKTESFIQPILDSMNFELVDVEYVKEGGMNYLRAYIDKEGGITVDDCEVVARQMNEILDREDYIPDSYTFEVSSPGLGRPLKKEKDYVRNMNKEIEIRTYRAINKSKEFYGLLKAYDKDTVTITDEDGNETTFNKSDIALIRQALDF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADB_AGRFC
Sequence: MSEFLPQRDWTVIVGSGMAGLMAAMTLAPQPVLLVTRGALGGETSSAWAQGGIAASLGPDDRAALHVADTLAAGDGLCDEDMVVGIVSSAPAVIDALERAGVRFDRDAGGNYVFGLEAAHSRRRILHAEGDGSGAAIVRALTDAVRRTPSITVLEGTEVRRLLTEDSVIAGLACAGPNGSFLLPASQVILATGGLGGLYDATTNPSGNFGQGIMLAARAGAILADMEFVQFHPTALSSPRRPLALVSEAVRGEGALLLNENGERFMAAVPGAELASRDIVARAIDREILRGGQVFLDARQALGSGFASRFPSIDLLCREAGIDPARELVPVRPAVHYHMGGVATDNKGRSSVRGLWVAGETACTGLHGANRLASNSLLEAAAMGMRAAQDIAGRPAPAARSAAAVSPNATADFSPADLAAVRPIVSRHLGIVRHAAGLAEAIRDLLPLAERNGPASDPAVVALSIAVFAALRRESRGAHFRDDFSQKDAKAMRRRLSLNDVVTVAHEFSSSSLATAGFARSA
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y647_XANOM
Sequence: MPSFDVVSEVNKHELTNAVDQANRELDTRFDFKGVQAKFELEDGKVINQSAPSDFQVKQMTDILRARLLARGIDVRCLEFGDMETNLAGARQKVTVKQGIEQKQAKQLVAKLKEAKLKVEAQINGDKLRITGKKRDDLQDAIALLKKADFELPLQFDNFRD
What are the official names of this protein?
UPF0234 protein XOO0647.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: PHOSP_PI4HA
Sequence: MSFEISVEEIEELIETGNLNIDHALKELGATSQSSLNKPPSQSSRTEGNDGGTKISRNPAPVEAPAHTSTAQRSHNEENESGRQNLDSLSMISNKPQTGTLLMGSDTQLPSPSKTYQGLILDAKKRALNEPRRDQKITNEHGSMNDTRIFKRGGNIDTRKEAWVTQNQRSRTQPPLQDIEESTRFHGLTEEPQYPSGAIHAAHQSNQLPLSKNAHVEDVPKFANYASEILDAIKALEVRLDRIEGKVDKIMLTQNTIQQTKNDTQQIKGSLATIEGLITTMKIMDPGVPSKVSLRSLNKESEQVPIIVTGNGDVSKFVDQDNTITLDSLARPILSGTKQKTDERRAGVRIDALKITVSEMIRDLFGDCDKSKKLLESINMATTEQDINLIKTNALRSIT
What is the function of this protein?
Essential component of the RNA polymerase and the nascent chain assembly complex.  Also required during RNA synthesis.
What are the official names of this protein?
Phosphoprotein, Protein P.
What is the protein family that this protein belongs to?
Belongs to the rubulavirus/avulavirus P protein family.
Protein: RS7_STAES
Sequence: MPRKGSVPKRDVLPDPIHNSKLVTKLINKIMLDGKRGTAQRILYSAFDLVEQRSGRDALEVFEEAINNIMPVLEVKARRVGGSNYQVPVEVRPERRTTLGLRWLVNYARLRGEKTMEDRLANEILDAANNTGGAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: MUTS_DESHY
Sequence: MPRQSISKESPTMTTPMMQQYKSIKSQAPDAILFFRLGDFYEMFGEDARTAAPILEIALTGRDSGGGERIPMCGVPHHAVDGYLLKLVSAGYKVALCEQVEDPQAAKGIVKREIIRIISPGTLTDSLVEQANNFLAAVYHEQDWGLAFVDVSTGEFTVFQTESLDILTTELSRIRPSELLLPAELLKAKHWRPYYLTQREKKTYQHTLLEERFTEQRELFQEFPTAMKAANGLWQYILETSPGIDPSHILKVNAYRPEHWMLLDPWTRRNLELTESIRGQGKKGTLLSVLDFTKTAFGGRLLRRWIEQPLLLKGEIEKRLDYVEALVEDSFLRGDLIQLFGKVYDLERLMGKVSYGTANARDLLSLAQTLGVLPQLRALLAEGKSEPLQAFIPALEGLDPLAATLEQAINPEAPISLKDGNLLKAGYSVEIDELRSISSGGKAWVAKLESMEKDRTGIRSLKVGYNKVFGYYIEVTHANSHLIPAEYIRKQTLANAERFITPELKEYEQKILGAEEKVTQLEYQLFLELRETVRGQAAKILEAAHALAEIDVYTSLAEAAVRHHYSRPVMKGEGGLTIIEGRHPVVESMLQDTSFVPNDTILTEDKHLALITGPNMAGKSTYMRQVALIVLMAQIGSFVPAQQATIPIADHIFTRVGASDDLASGQSTFMVEMYEVAHILRHVTPQSLIILDEVGRGTATYDGLSIAWAVAEYLAGQENKPKTLFATHYHELTDLEETHSGIFNLHVGVREHGEEIVFLHKIIPGRADRSYGIQVAKLAGLPANLLHRAKIILHELESSAKESRQEHLFNKEKATQLSLFEVQPLDPLLQEVSELSVEDLTPRQALDYLFDLKERIKAADSL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RL24_BRUC2
Sequence: MQKIRKGDSVVVLSGKDKGRKGEVLKVMPKDEQALVSGINIVKRHQRQTQTQEAGIISKEAPIHLSNLAIADPKDGKPTRVGFRVEDGKKVRVAKRSGALIDG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PPNP_AROAE
Sequence: MSLTEKFDSVTVATKANVYFDGKCVSHGIVLADGTKKSVGVILPATLTFNTGAPEIMEGVAGSCRVRLKGESEWTVYGAGESFNVPANSSFDIEVAGEPYHYVCHFG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: FTSQ_STRVP
Sequence: MAAGPTTAEKSGASGAKRSSKGSSDGPSRPGTRNRKFRMPGTRALLITLGVLLLVAGGLWALYGSTWFRVERVKTSGTSVLTPREVEAAAAVPLGAPLVTVDTDAIEARIRKELPRVDSVDVVRSWPHGIGLKVTERKPVLLIEKGGKFIEVDATGMRFATVDTAPRNVPRLVLDSASSPSLRRFDADRLLQEAVGVRGELPAEIARDTRVVRITSYDSVTLELTRGRTVFWGSGEHGAVKARVLTALLKATPKAGHFDVSAPTAPASSGS
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsQ.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. FtsQ subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: FABH_BRUA2
Sequence: MIRSVVRGIGSALPKRVMKNTDFEGIVETSDEWIVQRTGIRERHIAGEGETTVSLGAAAARAAIENAGLQPSDIDLVLLATSTPNNTFPASAVAIQRELGITRGFAFDLQAVCSGFIYAITTADLYIRGGMARRVLVIGAETFSRILDWTDRTTCVLFGDGAGAIVLEAAEGHGLTSDRGILAANLRSDGNHKEKLYVDGGPSTTQTVGHLRMEGREVFKHAVGMITDVIEASFEATGLTAEDIDWFVPHQANKRIIDASAKKLHIAEEKVVITVDRHGNTSAASVPLALATAVADGRIKKGDLVLLEAMGGGFTWGAVLVRW
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLOA_BACFR
Sequence: MNVEPMYLTIFLIAGGIIFLVLFFHYVPFFLWLSAKVSGVNISLVQLFLMRIRNVPPYIIVPGMIEAHKAGLSNITRDELEAHYLAGGHVERVVHALVSASKANIELPFQMATAIDLAGRDVFEAVQMSVNPKVIDTPPVTAVAKDGIQLIAKARVTVRANIRQLVGGAGEDTILARVGEGIVSSIGSSENHKSVLENPDSISKLVLRKGLDAGTAFEILSIDIADIDIGKNIGAALQIDQANADKNIAQAKAEERRAMAVATEQEMKAKAEEARANVIQAEAEVPKAMAEAFRSGNLGIMDYYKMKNIQADTSMRENIAKPIGGATSKPLSD
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Membrane raft; Single-pass membrane protein.
Protein: ACACA_BOVIN
Sequence: MDEPSSLAKPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVSSDTLSDLGISSLQDGLALHMRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLCVDWHENDFSKRILNVPQELYEKGYVKDVDDGLKAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPAAIATPAVFEHMEQCAVKLARMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDAPIDFENSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQLNRIGTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSISNFLHSLERGQVLTAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDVSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVLRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAAESGCIHYVKRPGAALDPGCVIAKMQLDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSRVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTRKNLLVTMLIDQLCGRGPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRLNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNAFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFCDSPPQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDSLAAMFREFTQQNKATLVEHGIRRLTFLVAQKDFRKQVNYEVDQRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDQLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSSQAFLPPPPLPSDILTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTLKSPEYPDGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVAANSGARIGLAEEIRHMFHVAWVDPEDPYKGYKYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGLGAENLRGSGMIAGESSLAYDEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHSTVCDDFEGVFTVLHWLSYMPKSVYSSVPLLNSKDPIDRVIEFVPTKAPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECSQPVMVYIPPQAELRGGSWVVIDPTINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSVAERKELESKLKEREEFLLPIYHQVAVQFADLHDTPGRMQEKGVINDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLVEWLEKQLTEEDGVRSVIEENIKYISRDYVLKQIRSLVQANPEVAMDSIVHMTQHISPTQRAEVVRILSTMDSPST
What is the function of this protein?
Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis.  This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
What are the official names of this protein?
Acetyl-CoA carboxylase 1, ACC1, ACC-alpha.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ECI3_ARATH
Sequence: MCTLEKRGDLFLLTLTGEDEHRFHPDTIASVLSLLEQAKSQSTKGSVLITTGHGKFFSNGFDLAWAQSAGHGAIKRMHQMVKSFKPVLAALLDLPMPTIAALNGHAAASGLMFALSHDYVFMRKDRGVLYMSEVDIGLPVPDYFSALVVAKVGSGIARRELLLSGKKLKGEEAVALGIVDSAAHDSAEGVVEATVSLGESLAAKKWNGEVYATIRKSLYPELCRMVDLTANNLATHNL
What is the function of this protein?
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.  Essential for the beta oxidation of unsaturated fatty acids.
What are the official names of this protein?
Enoyl-CoA delta isomerase 3, 3-hydroxyacyl-CoA dehydratase 1, Delta(3),Delta(2)-enoyl CoA isomerase 3, AtECI3.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: M1249_ASFP4
Sequence: MEEVITIAQIVHRGTDILSLNNEEIEALVDEIYSTLKGSNDIKNIRLIDFLFTLKDFVNHVRAEQSKLPDLSMPMEAYIRQLLVDSDVVPIVSEKKKELRVRPSTRKEIFLINGTHLAVPAEAPIEIYGLKLRLKTFSPQCFMRMAEIGSFSPETLGYVASGANLTNFIRVFMKCVDQETWKKNGEGVVVTTKENIIQFTHQYIELYKFLRSGGHSWLINRLAEEMVHRKLDREDQGSHISNIVETEEIEPEENIKRVIFFLKELSTMYSVSPVFTSGYMPLLYDLYRAGYLEVLWNPVEQKFLQHAEQREKEQMILQQVDMKLMEVTTQARQYFKIMEEKIGRVQSDAIREILTMEGKVDDPNSILQEVIKACGKQEAELITTEYLNIKKQWELQEKNACAHLKLVKQLRSGLQYAESLKVLESIRVLYKEKNNTTNWNLCKACGFKLLCPHVDMLIQLQAAEASYDTMRTKLMKFSGINKEKENNQGLIYSYFCKICGEELAHFIQEDRTADVGVIGDLNSKLRIFIWQETMKACTFIHFGKLVDVKQFANIAVNVCLPLVYSIENIKKEEDYDPLTQLYAVIYIYAYILNLIYSSQKNKEFLTITIHGMKADSSLNAYVTFLLEKMMQQYSGIINQLSEITDQWIANNFREAFKKIIHQNGLQGLSVQDDTKVLLTEILLDPLYDYAATVARIDGSIPMYKPRTPKEAEYEFKTVIGRTPAELLSQKEFYDKIYTSKYRPDFTQLARLKDIYFQEESLRVWWGGRDEEKTSTLIYLRAYELFLKYLQNAPNFNSELAEFKTYENAYGEQKALLAQQGFYNIFDPNTGRADQRTRLFEYKRLPISTLYDERGLPHKWTIYVYKAVDSSQKPAEIEVTRKDVIKKIDDHYALADLRCSVCHVLQHEVGQLNIKKVQTALKASLEFNTFYAFYESRCPKGGLHDFQDKKCVKCGLFTYIIYDHLSQPELVHDYYNNYKDQYDKEKMSIRSIQIKKDMTTPSTETQPKPPQEPWTFDYGKIIKTAKILDISPAVIEAIGAMEGRSYADIREGQGAPPPPTSMDDPRLMAVDSAVRIFLYNYNCLRHVSTFNKPPMHVERLVKHLSYEEKEDLEKVLPNVVNEYHTTFKHLRVTDPASALLYSIEFLCISFLTLYEIKEPSWVVNIVREFALTELNTIIQSEKLLSKPGAFNFMIFGEDFVCSGEDSSMDDISAYSSPGLFGEDIIDRLDDPFSIEDVDISLDVLDNLAPQ
What is the function of this protein?
Together with the penton and the other minor capsid proteins (p17, p49), forms a complicated network immediately below the outer capsid shell, stabilizing the whole capsid.  In addition, blocks IFN-beta transactivation mediated by the cGAS-STING pathway and regulates the transcriptional activity of IFN-beta.  Mechanistically, suppresses the phosphorylation of host key adapter protein TBK1 and degrades host IRF3 in the cyltoplasm.
What are the official names of this protein?
Minor capsid protein M1249L, pM1249L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus M1249L family.
What are the subcellular locations of this protein?
Virion.
Protein: BIOF_SYMTH
Sequence: MALTDFLVEELNGLKQAGLYRPLKELQSPQRPRSIIDGREVINLSSNNYLGLADDPRLKQAMIEATEAYGAGSGAVRTIIGTMTIHNQLEQKLAEFKHVEAAVVFQSGFTCNSGVIPVLVGEGDAVISDELNHASIIDGCRLSKAKIHRYKHADMDDLARVLKETDGQYRRRLIITDGVFSMDGDIAPLPDIVELAEKHGCMTYVDDAHSSGVLGKNGRGSVNHFGLDGRVTVQVGTLSKAVGVLGGYVAGPRALIELLWHKGRPFLFSTSHPPGVAAACLKAIEIMEQEPERIDRLWENTRYFKERLTELGFDTGKSETPITPVIVGDEVKAMQLSDRLLEEGVFAQGIAFPTVPRGKARVRTIVTAAHTKEDLDEALAAFAKVGRELGLI
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase, Alpha-oxoamine synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: RUVB_UREPA
Sequence: MKTNYEFRPQYLKDFIGKEQLKNNLKVYLTASKRLENSFDHTLLHGLSGTGKTTLALIIANEMNVNCHITQGNLLNKPIDIINLLSLIKENDVVFIDEIHACGLGAFETLYSVLEDFCIDINIGKDFNSKMTRLKIPHFTLIGATTIFGKIPKSLEERFGHIFHLNEYEPSEISAIILKNNQMHFQIDLNEEEIDLIANNAKGIPRLANRLLKRVVDFKINGFNDIKNIFKKIQIYEFGLDEQDINYLNVLYRQDNEIGLKSIAQILRLDQYTIETKIEPYLIQHHFINKNLRGRKITIEGIDFLKNNQLIK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PXPA_NEIMF
Sequence: MKQVDLNADLAEGCGSDEALLQLITSANIACAQHAGSIADIRAALAYAQQNGVRIGAHPGYPDRENFGRTEMNLSEADLRACLNYQLGALQALCRDQGLEMAYVKPHGAMYNQAAKNRALADTVARIVADFDPKLKLMALSGSLLLEAGKAAGLGVISEVFADRRYMPDGTLVPRSRPDAQVDSDEEAIAQVLQMVRDGQVKAVDGSLVAVQADSICLHGDGPHAVVFAEKIRQELLAAGIKVSA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: FMT_CHLCV
Sequence: MLNLKVIYFGTPQFAATVLEDLLHHDVNVIGVVTRVDKPQKRSSQPIPSPVKTLALSKNIPLLQPEKASDPQFIEQLKAFEADVFIVVAYGAILRQVVLNIPKYGCYNLHAGLLPAYRGAAPIQRCIMDGVTQSGNTVIRMDAGMDTGDIAGVSYVPVGPDMTAGELAEALSAQGGEILIKTLQQISDGTISHTPQDSSKASIAPKLSKEEGFVLWNHPAEKVYAQIRGVTPAPGAWTLYSYQDKPAKRLVIRKASLASNKGIYGNPGDVIVSDQQELLIACAEGAICLKEIQPEGKGAMDSKTFLNGHSNHKLKLSFQNN
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: HIR2_ARATH
Sequence: MGQALGCIQVDQSNVAIKETFGKFDEVLEPGCHCLPWCLGSQVAGHLSLRVQQLDVRCETKTKDNVFVTVVASIQYRALAESAQDAFYKLSNTRNQIQAYVFDVIRASVPKLDLDSTFEQKNDIAKTVETELEKAMSHYGYEIVQTLIVDIEPDVHVKRAMNEINAASRMREAASEKAEAEKILQIKRAEGEAESKYLSGMGIARQRQAIVDGLRNSVLAFSESVPGTSSKDVMDMVLVTQYFDTLKEIGASSKSNSVFIPHGPGAVRDIASQIRDGLLQGNSAAE
What are the official names of this protein?
Hypersensitive-induced response protein 2, AtHIR2.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: ISPF_ALKEH
Sequence: MIRVGQGFDAHRFGEPGTPLILGGVQVPHERGLAAHSDGDVLMHAVTDGLLGAAGEGDLGTHFPDSDDAYKGIDSRILLRDALQRVRAGGWRVVNVDATLIAQAPRMNPHVGAMRDHLAADLEVAPSAVNVKATTTERMGFPGRGEGIAAMAVVLIARDGFFEH
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: FPG_BARBK
Sequence: MPELPEVETVRRGLEPVLMGSRIISVSLGCKNLRFPFPESFSERLTGRIIIKLSRRAKYLLFHLSQNETIVSHLGMSGSWRVEDDLLRKKHSYMGKLVAHDHFIMSFQATNGKIYRLIYNDSRRFGFMLLADTMRLYEHPLLRNLGLEPIDNAVSGAYLQKAFINKKTSLKAALLDQSIVAGLGNIYVCEALWRSYLSPERRALTLASKSAHACELAKCLAQNICDVISEAIFSGGSSLRDYVHIDGSLGYFQHCFSVYGREGKECSRCGMHIVRIVQSGRSSFYCPQCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.