PharMolix/UniProtQA huggingface dataset:
Protein: RL14_MYCMM
Sequence: MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDIIVATVKDAIPGGNVKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGTRIFGPVGRELREKRFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: TM210_MOUSE
Sequence: MAPCPQPESCPAGSPLGLICLSLLLIPASAGTYCECSLGLSREALIALIVVLAGVSASCFCALVVVAIGVFRAKGDTCPGHSENRLVGPYGVQEDRIDLHTVHVESHLMDPDLDVSMMPSLDGPGLMTMTAPLEPPPPPPPPPPLPQ
What are the official names of this protein?
Transmembrane protein 210.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: FUMC_HALH5
Sequence: MNTRIERDTLGEMHVPQDKLWGAQTQRSYENFHIGTEKMPMEIIYAFALLKKAAANVNKKLGQLSAEKADAITWAANEVLAGKHDDHFPLFVWQTGSGTQSNMNMNEVLARRGNQLLQEKGLDVTIHPNDDVNRSQSSNDTFPTAMHIAAYNKLDDHLLPTLQMFKQTLHQKAKQFDDVIKLGRTHLQDATPLTLGQEISGWARMLEKTEQMIRESMIYLQELAIGGTAVGTGVNAHPKFGEMVAADIANETGKPFKSAANKFHALTSHDELVHTHGALKALAADLFKIANDIRWLASGPRGGLGELIIPANEPGSSIMPGKVNPTQSEALTMITSQVIGNDATIAFAASQGNFELNVFKPVIIYNFLQSTTLLTDGLRTFHDKCLIGLEANETIIKKHLNESLMLVTALNPHIGYENAAKIAKKAHAEGLTLKEAAMQSGLLTEEEFEKMVDPAKMVHPQG
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
Protein: GEFS_DICDI
Sequence: MGEVSLIGITAILCQKTDGFWKNIDDSLCRLEVLKSNIDSKFRLVAISTDNRCIFNKWVRTNSEITKCSDLFLEIKQVSSQSSNVEYFGVNFAYKPEVDKFYACFSKCIETLQTQRRQSTLNIQALQINNELQQQLQQQQQLPPIDQLPPPPTSTSTSTISNANISISNSISYDSLHQMASGITLEDLPPPPPSASSLILNNNTPLDLTSLPPIDFSNLPPPPTGLMTSRSSLTEANGLEIKNKLSPLLNGGASGLSSSPPPTTESKNQLNSSSGSNNSSSAPHLTDLFLPTNNNNSSGNQSASNSSPTSQYHQSQPNLQQYGTAPLTASSKLLQQQQQQQQQQQQNIIMTTTTTTTTTINIKTGSSSDSFLKTASGRRSIRVRHSTNQAADQQKKTMGRKDGLAVSLQNVEGLQNIAENLEDETLNLLDLVNEQVVTPEISNNAHLNQSLMKIFEHLQVLFILTGQASTHPGGKLITQVVNKLGRGPQASEFFSGKSVDGGYQWYNLDEVKDSVIGIHNLLALKKNLITAIAHLSTCVRVLGLQASLEIDWMSRNKSSETEKIVVQLACLTRELISSMSRLLAATVTYCYVCSSIAFIRNQQHSASADHNQASIQNRIRSPSTIDTINIWDELKTIKTIPTVPKDGSILKVTLNQLVLMLTSETSYDSKFLKTFITTYQSFASPGVLFTKLIERFYVPEWYSTVPTKISTIQQKVIVVLKYWIENQSSDFDQDVIDQIYFFINNLANSNEGYSELSRLLRGLLDKMIQDREVKFELLFQMPPRISFEEDSILSPIELFSEWSAQSIAQQLTLIDFSIFKDLEARELLNQNFNKPKLKYKSPTIMRMISKSTQFSFWVAYVILMEPKKEKRIKIFEKFCEVGKYLLKMNNFNSLMGLNAGLNLTCVHRLKKTKKKLSSSAISILTELERIFSSKKSFKNYRDHLSTVQLPCIPYLGFNLTDITFIEEGNTDNISSTDPAAANIGPLINFKKRELLYQAWADLSRFQETPYTFQPEEPLNTFLLNFPILDDKELYDLSIALEPK
What is the function of this protein?
Promotes the exchange of Ras-bound GDP by GTP.
What are the official names of this protein?
Ras guanine nucleotide exchange factor S, RasGEF domain-containing protein S.
Protein: PYRDB_BACC0
Sequence: MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRVAETPGGMLNAIGLQNPGLEKVMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPNVHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEVPVYVKLSPNVANIVEIAKAIENAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPIIGMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGRSWKQTCHSR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAB2_METVS
Sequence: MKITEFLNNKKGASGIGTLIVFIAMVLVAAVAASVLINTSGFLQQKAATTGKESTEQVASGLQVLQIMGVHDSSNITKLAVYIAPNAGSSAVDLSQSVVTLSNGDVKSIFKYDTTDAAADKSYGAVKTGGSLFAEATLNISNMTNTQFGIIVIQDADGSCKAATPVLNKGDIVAIVLNLNETMTEPRTAITGSIQPEFGAPGIISFTTPATYLDGSTVVQLQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
What are the official names of this protein?
Flagellin B2.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: SSRP_WOLTR
Sequence: MEVIAENRKARFEYFILEEFEAGMVLLSSEVKSLRERKVNISDAYVTEKNGEIWLHNMHIAEYKAANKKKHKPKRERKLLLHKKEINKLISQIKTAGVTIVPLSIYFNDKGLVKTRIAIVKGKKLYDKRATIKQREWNRAKSRLSKNNL
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: COAE_BURTA
Sequence: MFSVGLTGGIGSGKTTVSNLFGALGATIVDTDLIAHRITAPHGLAMPFIEREFGAQFVAADGSLDRAKMRALIFSDESARKRLEAITHPLIREETEREAGAAHGAYVVFVVPLLVESGTWEARVDRVLVVDCDVETQIARVMSRNGFAREQVEAIVARQASRDARLAAADDVIVNDNASLDELAAEVAALHQRYLGYAAAAPN
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_CERS5
Sequence: MTVDAVRVELGARAYEVRIGPGLIARAGAEIAPLLRRPKLAILTDETVAGLHLAPFQAALAEAGIASSALALPAGEATKGWEQFSRAVEWLLEEKVERRDVVVALGGGVIGDLAGFAAAVLRRGVRFVQVPTTLLAQVDSSVGGKTGINTAQGKNLVGAFHQPSLVLADIGVLESLPARDFLAGYGEVVKYGLLGDADFFEWLEGAAPRLASDPEARQRAVRRSVEMKAEIVARDETEEGDRALLNLGHTFCHALEKATGYSDRLLHGEGVAIGCALAFELSQHMGLCPQEAPSRLRAHLRAMGMKVDLRDIPGDLPDAEGLLRLMAQDKKVVDGKLRFILARDIGAAFVAKDVPGDLVRRILQEALATR
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM258_XENTR
Sequence: MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDVYKELLISLVASLFMGFGVLFLLLWVGIYV
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Transmembrane protein 258, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258, Oligosaccharyl transferase subunit TMEM258.
What is the protein family that this protein belongs to?
Belongs to the OST5 family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Endoplasmic reticulum. Cytoplasm.
Protein: ISCS_ECO7I
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFMTMDGTFGNPASRSHRFGWQAEEAVDIARNQIADLVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLKELEAAMRDDTILVSIMHVNNEIGVVQDIAAIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMATEMERLRGLRNRLWNGIKDIEEVYLNGDLEHGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSLGRFTTEEEIDYTIELVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_XYLFM
Sequence: MNMEATAILRGARISPQKARLVAAQVRGLSAESAVNLLRFSSKKAACLIKKVVESAIANAENNHGSNIDDLKINTIIVDEGRMLKRFMARAKGRSSRIVKRSSHITVVVGPAK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: KHDC4_XENTR
Sequence: MSAGSGRRSKWDQPGPPSTTLLLPGVLPAIVPFTAGAFLSPPEMPPVTATCESVSAPSGALDAAAAVAAKINAMLMAKGKIKPTQNAPEKVQVPGKAPSAAKSKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRMSGAAVSTRGRYMTAEEKAKIGPGDRPLYLHVQGQTRELVDRAVNRIKEIITNGVVKAATGSSPTFNGATVTVYHQPAPVAPVAPPKPQFQSGMHYVQDKLFVGLEHAVATFNVKEKVEGPGCSYLQHIQLETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAAKKLCENLLQTVHSEYNRFVNQIATTAPLTGYAQPPQIGAVPMQPQYYPPNGYQTGFPVVQQPAPQPAVQVPYVVSTPIGSPVPPLPGVVPTMAAPVPPVPAVPTRYPIPQVQPPGSTVPAQLTAPYMPAPHGKHAAAVVTQAPLQGQKRRFTEELPEERDSGLLGYQHGPIHMTNLGTGFPAQSKVDGATIKSDTMVVKERERDRQLMPPPGMPVSAQKEPEEKSSPGTVGVADDYPVKKLKSSGKTFGLVAYAGDSSDEEEDHGVLKSSGSLSQGWNAGYQYPASQQQQRAKPQMPFWMAP
What is the function of this protein?
RNA-binding protein involved in pre-mRNA splicing.  Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome.  Involved in regulating splice site selection.  Binds preferentially RNA with A/C rich sequences and poly-C stretches.
What are the official names of this protein?
KH homology domain-containing protein 4, Brings lots of money 7, Pre-mRNA splicing factor protein khdc4.
What is the protein family that this protein belongs to?
Belongs to the KHDC4 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: 3604L_ASFWA
Sequence: MNSLQVLTKKVLIETKAFSNYHEDDIFILQQLGLWWHNGPIGFCKQCKMVTSGSMSCSDDDSYELDRALVKAVKENQTDLIKLFVLWGAEINFGIMCAKTKQTKDLCIQLGADPQFLDVGLYNMFVYLVKRKKVLLAIEIYYDNILILDSFDSYDFHLLIDFVYNRFILYLDEKDEEMTRNALVLKFWYKFAIDFKLVKPIRYLSKKFPHLDIWRLKAAIYLGNIDEVHRAYFQENIRLDPNDMMLLACMYPQNKLGIYYCFALGADIDNALDILLRFDETNKQIHRETRGEIIFNIERGYLINIYFCISLGANPYIKKIQDTIKQKHSNIMILLFSKKKLLSPHSVLQNKILDPSDVYKMISTYENTESFYPFSSLAVKLIQQAK
What is the function of this protein?
Plays a role in virus cell tropism, and may be required for efficient virus replication in macrophages.
What are the official names of this protein?
Protein MGF 360-4L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus MGF 360 family.
Protein: ATPD_METFK
Sequence: MAEAITIARPYAVAVYRLAKEKNALADWSQMLALAAAIAADEQMRAFIDNPKVDAADLERVFLSVSGDRLNEAGTNLIKLLVEYGRLSILPEIAAAFEALKAQDEGVLEAEITAAVQPSDAEFSAIVKRLEAKFGKKVEASVKVDPEIIGGIKIVVGDTVIDASVRGQLQELAYTLKG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PUR5_BACAH
Sequence: MANAYKQAGVDIEAGYEAVSRMKKHVQTTMRKEVLGGLGGFGGMFDLSKFALEEPVLVSGTDGVGTKLMLAFMADKHDTIGIDAVAMCVNDIVVQGAEPLFFLDYIACGKAEPSKIENIVKGISEGCRQAGCALIGGETAEMPGMYSTEEYDLAGFTVGIVDKKKIVTGEKIEAGHVLIGLASSGIHSNGYSLVRKVLLEDGELSLDRIYGRLELPLGEELLKPTKIYVKPILELLKNHEVYGMAHITGGGFIENIPRMLPEGIGAEIELGSWKIQPIFSLLQEVGKLEEKEMFNIFNMGIGMVVAVKEEDAKDIVRLLEEQGETARIIGRTVQGAGVTFNGGKAL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14Z_DEIDV
Sequence: MANTSKVVKAARGHKFAVQNYSRCSRCGRARGYYRFFGMCRICIREMAHKGELPGVKKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: RSD_ECOSM
Sequence: MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_CLOBM
Sequence: MSRSVKKGPYIQEVLLKRINEMNKNGEKKVLKTWSRSSTIFPQMIGHTIAVHDGRKHVPVYITEDMVGHKLGEFVLTRTYRGHDDKSEKSSRLR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: CENPA_MOUSE
Sequence: MGPRRKPQTPRRRPSSPAPGPSRQSSSVGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFEDAYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP
What is the function of this protein?
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes.  Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore.  The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3.  May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).  Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:27499292).
What are the official names of this protein?
Histone H3-like centromeric protein A, Centromere protein A, CENP-A.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height. Phosphorylation at Ser-62 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location.
Protein: ISPE_BACC2
Sequence: MKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELTELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKEKFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDELAELGAEIGSDVSFCVYGGTAIATGRGEKIEHIKTPPSCWVILAKPHIGVSTADVYGNLKLNRVTHPNVDKMVDVINSGDYKGICDTVGNVLEDVTFGMHPEVARIKSQMKRFGADAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQVYAVRLLGERETLE
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: ZNT10_HUMAN
Sequence: MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF
What is the function of this protein?
Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481).  Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.  Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:27226609, PubMed:27307044, PubMed:26728129).  Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129).
What are the official names of this protein?
Calcium/manganese antiporter SLC30A10, Solute carrier family 30 member 10, Zinc transporter 10, ZnT-10.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network. Recycling endosome. Early endosome. Note=Relocalized from the trans-Golgi network to the plasma membrane upon elevated extracellular Zn concentrations (PubMed:22706290).
Protein: ASPG_DIRIM
Sequence: MQCEEAHVLVLYTGGTIGMKYIDGVYQPEANYLLHAIRDLSLLNDDDYVSTYYSDAEIRPYCLPPLQHSKKRVVYWMIEYDPLLDSSDMTFDDWIHIGKDIQRAYDQYVGFVILHGTDTLAYTACALSFMLENVRKPIVITGAQIPVCEVRSDGRENLIGALIIAANYDIPEVTVYFNNKLFRGNRTVKIDNRSMDAFESPNMLPIAYMDVDIKVNYDSIFRSPSMAPFVVHDQLCRNVGLLRIFPSMSIENVRASLQAPIEGVVLQTFGAGNMPSHRTDIIDELKKAVDRGCIIINCSQCVRGQVDIHYLTGKVLYDMGIIPGSDMTAEAALTKLSYVLSKDCWELVEKKAMMVKNIRGELTVAKAEPLKDLEIVSQMARFLHLSSSHEMKLLCHAIFPQLLCYAASNGDIEMLKALHENGVDLSVVDYNGRNALHVAASAGHVGAVKYLLTQGVSFHLRDQWDENALVSAVKMKNKILIETLRSAGALLSINSRRLGVELCLCASYGDTETLNSWLAAGADINQQDYNGETALHIAVKSRNKQLVHYLLDRDADPYKIDDFNLTPLRHAKKLNLQDLVIRMKKMKKVQ
What are the official names of this protein?
L-asparaginase, DiAsp, L-asparagine amidohydrolase.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the asparaginase 1 family.
Protein: ESIP1_MOUSE
Sequence: MYTRSKVVGPGLGTSSISRDHAGAGQRRELGLQQNRRQSLEVAAPEGPKMERQGHADQGSAGTYTLIAPNESRRQKIQRIAEQELADLERWKQQNRAKPVYLVPQRLGGSQSEAEVRQKQQLQQMRSKYQQKLKRDESIRIRKEAEEAKFQKMKAIQREKSNKLEEKKQLQEDIRRATFREHHQSKTAELLSRLDTERRNRSACLIAPPATQSSRWKLPVLLRDPSWAGSQAHRDSPQKEDNPRLQKTRDGHQKNKLLETKGQHQEEERAQIHQAEHWRVNNAFLDRLQGKSQPGGLEQSGGCCNMNSTDSWGL
What is the function of this protein?
Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (PubMed:29217193).  Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (PubMed:29217193).
What are the official names of this protein?
Epithelial-stromal interaction protein 1.
Protein: RS20_CERS5
Sequence: MANSPQSKKRARQAEARAAVNKARRSRIRTFLRKVEEAIASGDPAAAAAALKTAQPEMARGVTKGVLHKNTVARKMSRLAHRVKVLSVPAAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: Y1642_SYNWW
Sequence: MNEYFVNLNIKEMPETMRPREKLIARGEDKLDEAELLAIVLGSGTREMNALELARQLLARHGGSLRFLMSATLEELTAEKGIGMAKAVSIKAAIEMGRRVVGNIQLRRIIKSPEDVQEAVRELAMEEMRHYDREHFRVLYLDRKGGLITMQDISIGGLHSSIVHPREVFKTAVKKSAASMILVHNHPSGDPTPSQEDIEITRRLIEAGKIMGIEILDHVIIGEINYCSLKARGLI
What are the official names of this protein?
UPF0758 protein Swol_1642.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: TIFA_BOVIN
Sequence: MSSFEDADTEEMVTCLQMTLYHPGHQRSGIFRSIKFFNREKLPTSEVVKFGRNSHTCNYIFQDKQVSRVQFSLQVFKKFNSSVVSFEIKNMSKKTSLLVDNKELGYLNKMDLPDKCMIRFGDYQFLVEKEDGESLEFFEIQFSLSKKPLLQENNWLSQEPIPECGSYSSCLTQNNSPMEVGENEW
What is the function of this protein?
Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs).  Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.  TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling.
What are the official names of this protein?
TRAF-interacting protein with FHA domain-containing protein A.
What is the protein family that this protein belongs to?
Belongs to the TIFA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation.