PharMolix/UniProtQA huggingface dataset:
Protein: Y468_STRE4
Sequence: MDIRQVRETVEMIEEQHFDIRTITMGISLLDCIDSDIDRAAAKIYQKITTKAANLVAVGDDIAAELGIPIVNKRVSVTPIALIGAATDAEDYLSLAKALDQAACDIGVDFIGGFSALVQKGYQKGDKILIESIPQALAQTQKVCASVNVGSTRSGINMTAVADMGRIIKETAKASEIGAAKLVVFANAVEDNPFMAGAFHGVGEADTVINVGVSGPGVVKRALEKVRGESFDVLAETVKKTAFKITRIGQLVGQMASERLGVGFGVVDLSLAPTPAVGDSVARVLEEMGLEIVGTHGTTAALALLNDAVKKGGVMACNRVGGLSGAFIPVSEDEGMIAAVQGGSLNLEKLEAMTAICSVGLDMIAIPEETPSETIAAMIADEAAIGVINQKTTAVRIIPKGKEGDMIAFGGLLGTAPVMAVNPHSSADFIARGGQIPAPIHSFKN
What are the official names of this protein?
UPF0210 protein SEQ_0468.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: FBX5B_XENLA
Sequence: MMCGFTSNPSPKKLLSKSSATNVHLEISPVKPDRPCKGYENVLGSCTTVAKCADLTDDLPVHNKENLLHGFNDLERHHDEENSSLQDSGYSSILQNDSPCQDETDSNVSDIQVRDTPKNLMQYQKPFHTLSTRCLPILRFEAAMCSTLKKMRKTSKKIDWNAVDDVVCGGNYGLEHLIGKSMGLERVDILAELFHRDFKHLLTKILRHLNAMDLINVIGVSTTWRKILQKDNWAYNTYKLGCKELCEKRAKVSTHTATRDESLCRVPLASVQKVAASSLCTSKKQNKNGGLSNNRHAEFIEVAQTLKNDQSLKACVDCGSPAKYDSYLHRAICTRESCKLDFCTLCSCKYHSSKSCLISKPRSYRIPIEPLPGSKKSKQNLRRL
What is the function of this protein?
Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC).  Binds to the APC activators cdc20 to prevent APC activation.  Can also bind directly to the APC to inhibit substrate-binding.  Required to arrest unfertilized eggs at metaphase of meiosis II, by preventing their release from metaphase of meiosis II, through inhibition of APC-dependent cyclin B destruction leading to stabilization of cyclin B-cdk1 complex activity.
What are the official names of this protein?
F-box only protein 5-B, Early mitotic inhibitor 1-B.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle. At metaphase, localized at mitotic centrosomes. Decreases centrosome localization as cells progressed through telophase.
Protein: RBL_BLEOR
Sequence: YYTPDYKTKDTDILAAFRMTPQPGVPAEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEENQYIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFIGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEALFKSQAETGEIKGHYLNATAGTCEEMLKRAVFARELGAPIVMHDYLTGGFTANTSLAFYCRDNGLLLHIHRAMHAVIDRQRNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREVTLGFVDLLRDDYIEKDRCRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGPNL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RNPH_HISS2
Sequence: MRPNARAINQPRPIKITRHYTKHAEGSVLVEFGETKVICTATVEDSVPRFLKGQGKGWVTAEYGMLPRSTHSRMQREAAKGKQGGRTMEIQRLIARSLRAMVDLEALGERAITLDCDVIQADGGTRTASITGACVALIDAINFLLQNGTLTTNPIKGLVAAISVGIVNGETVCDLEYVEDSIAETDMNVVMMEDGRMIEVQGTAEGEPFSHAELLTLLDLAKQGCEQLFVAQRVALAE
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: 064R_FRG3G
Sequence: MQNFGAQEMRKGRLAFVRLSKLETLQNLIDKMLAERVFNKGEAADILESNDIRADIARALIDSVTKKGDVACSLFAGAIARQDVVLADAMGISQV
What are the official names of this protein?
Caspase recruitment domain-containing protein 064R.
Protein: Y018_HVAVE
Sequence: MTNVVIDTKPVWGNMLPQLKWKDGTVVISEDDKHNEPYGIGKFFNFKEDFTRLYFKAIVNNPRERKTIEALISLPRSVADVCNPGGVYLGGRTLVDNVAKKFATIKASVDANGKVGYDTSDLERLGVRCRYYVDDLVKDDALMRRILLENKWKSKYPALVKPYEEYQRSKPKTIVLPTNRNNPVRSNVDIKPVNPPSSKVVKTVETDERLKDPPHTGALKTLIPLQKPIAPVQISEKPVVVKPEIKSPSKVIQTPDPQTVVAGKIIPNNESADSRSLFGSPVLLICVASLLLLIIIL
What are the official names of this protein?
Uncharacterized protein ORF18.
What is the protein family that this protein belongs to?
Belongs to the ascovirus HvAV ORF18 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: Y1822_SALRD
Sequence: MATTNDIGDRGEEIAAAHLDGAGYEILARNYRHSRNEVDLVCRETDAGEYVFVEVKTRSGTGFGAPEASITAKKRAALQHAARGYLHEHGAEGAPARFDVVAVMLTGGPPEVQHYENAFWAD
What are the official names of this protein?
UPF0102 protein SRU_1822.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: C1TC_DROME
Sequence: MSAQYQRFLKVLEKWPAEKSKVGSGEWTAEPAIKMSGAKIISGTAVAKSIREELRNEVTAMSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAHVQLPRSITEVELLDKINDLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRLAIGDLGGFLPCTPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLKWANATVTVCHSKTRNLEEITRSADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAEALQVAGHLTPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQWALQTLPLKPQRPVPSDIVIARAQKPKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVVAGMTPTPLGEGKTTTLMGLVQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPMEEFNLHLTGDIHAVSAANNLLAAQLDTRIFHENTQKDKALYDRLVPAIKGQRKFSPIQLRRLQKLGITKTDPDTLTADEYGPFARLDIDPDTIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVASEIMAVLALSRSLEDMKQRLADMVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNLMQSLEGTPVLVHAGPFANIAHGCNSIIADEVGLKLVGKNGFVCTEAGFGSDIGMEKFCNIKCRTSGRKPNAMVLVATVRAIKMHGGGAPVTPGAPLNKQYTEENLELVQKGLPNLLQHIENGKAFGMPVVVSLNAHSADTPAEHELVKKAALEAGAFAAVVSTHWADGGAGAVQLADAVIKACEQGNQFRLLYDLELPLVDKMNKIATTMYGAGKVVLSPAAEEKVKRLTDAGFGNLPICMSKVSGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGFVVAMCGEVTKMPGLPTRPAIYDIDLNTETGEIEGLF
What are the official names of this protein?
C-1-tetrahydrofolate synthase, cytoplasmic, C1-THF synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSP9_PLAF7
Sequence: MMNMKIVLFSLLLFVIRWNIISCNKNDKNQGVDMNVLNNYENLFKFVKCEYCNEHTYVKGKKAPSDPQCADIKEECKELLKEKQYTDSVTYLMDGFKSANNSANNGKKNNAEEMKNLVNFLQSHKKLIKALKKNIESIQNKKHLIYKNKSYNPLLLSCVKKMNMLKENVDYIQKNQNLFKELMNQKATYSFVNTKKKIISLKSQGHKKETSQNQNENNDNQKYQEVNDEDDVNDEEDTNDDEDTNDEEDTNDDEDTNDDEDTNDEEDTNDEEDHENNNATAYELGIVPVNDVLNVNMKNMITGNNFMDVVKNTLAQSGGLGSNDLINFLNQGKEIGENLLNITKMNLGDKNNLESFPLDELNMLKDNLINYEFILDNLKTSVLNKLKDLLLRLLYKAYVSYKKRKAQEKGLPEPTVTNEEYVEELKKGILDMGIKLLFSKVKSLLKKLKNKIFPKKKEDNQAVDTKSMEEPKVKAQPALRGVEPTEDSNIMNSINNVMDEIDFFEKELIENNNTPNVVPPTQSKKKNKNETVSGMDENFDNHPENYFKEEYYYDENDDMEVKVKKIGVTLKKFEPLKNGNVSETIKLIHLGNKDKKHIEAINNDIQIIKQELQAIYNELMNYTNGNKNIQQIFQQNILENDVLNQETEEEMEKQVEAITKQIEAEVDALAPKNKEEEEKEKEKEEKEKEEKEKEKEEKEKEEKEKEEKEKEEKEEEKKEKEEEQEEEEEEEIVPENLTTEESK
What is the function of this protein?
During the asexual blood stage, involved in the sialic acid-independent (SAID) merozoite invasion of host erythrocytes by binding to host SLC4A1/Band 3 protein on the surface of the host erythrocyte.
What are the official names of this protein?
Merozoite surface protein 9, 101 kDa malaria antigen, Acidic basic repeat antigen, p101 protein.
What is the protein family that this protein belongs to?
Belongs to the plasmodium ABRA family.
Protein: IBMP_CAMVS
Sequence: MENIEKLLMQEKILMLELDLVRAKISLARANGSSQQGDLSLHRETPEKEEAVHSALATFTPSQVKAIPEQTAPGKESTNPLMANILPKDMNSVQTEIRPVKPSDFLRPHQGIPIPPKPEPSSSVAPLRDESGIQHPHTNYYVVYNGPHAGIYDDWGCTKAATNGVPGVAHKKFATITEARAAADAYTTSQQTDRLNFIPKGEAQLKPKSFAKALTSPPKQKAHWLMLGTKKPSSDPAPKEISFAPEITMDDFLYLYDLVRKFDGEGDDTMFTTDNEKISLFNFRKNANPQMVREAYAAGLIKTIYPSNNLQEIKYLPKKVKDAVKRFRTNCIKNTEKDIFLKIRSTIPVWTIQGLLHKPRQVIEIGVSKKVVPTESKAMESKIQIEDLTELAVKTGEQFIQSLLRLNDKKKIFVNMVEHDTLVYSKNIKDTVSEDQRAIETFQQRVISGNLLGFHCPAICHFIVKIVEKEGGSYKCHHCDKGKAIVEDASADSGPKDGPPPTRSIVEKEDVPTTSSKQVD
What is the function of this protein?
Enhances the ribosomal termination-reinitiation event leading to the translation of major open reading frames on the polycistronic viral RNAs.
What are the official names of this protein?
Transactivator/viroplasmin protein, Tav, Inclusion body matrix protein.
What is the protein family that this protein belongs to?
Belongs to the caulimoviridae viroplasmin family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in cytoplasmic occlusion bodies.
Protein: TRPD_SHESR
Sequence: MSATSIQPLLDILFQGKALTREQTASLFSTLIQGEMNEAVMAGMLMALKIRGETIAEISGAADAMRAAAKPFPYPSSKRTEGIIDIVGTGGDGFNTINISTTAAFVAAAAGAKVAKHGNRSVSSKSGSSDLLAQFGIDLTMSPELASRCLESLNLCFLFAPHYHGGVKHAVPVRQALKTRTLFNVLGPLINPARPEFMLLGVYSPELVTPIARVLQALGTQRAMVVHGSGLDEVALHGSTQVAELKDGEIIEYQLTPADFGVPQAQISELEGGEPAQNAQITQSILQGQGSDAHTHAVAINAGCALYLCGLSDSVKAGTALALNTIKSGKAFELLNQLAKVSSETQE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: LPXA_AZOVD
Sequence: MSLIDPRAIIDPSATLAPDVRVGPWTLIGPHVHIGEGTEIGPHVIVRGPTWIGRHNRIFQFSTIGEDTPDLKYKGEPTRLVIGDHNVIREGVTIHRGTVQDRSETTIGDHNLIMAYVHIGHDSVMGSHCILVNNASLAGHVHVGDWAILSGYTLIHQHCQIGAHSFVGMGSGVSKDVPAFVTVLGSPAQARSMNFEGMRRRGFSPEAMNALRRAYKVVYRQGLTVEQALVELEESAKQFPEVAIFRDSVRASTRGITR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF69R_ASFB7
Sequence: MLLYIVIIVACIISKLVPNEYWAIHLFFIIMIFMVYMYEKLDIHQKYQFWNYTMSGLSGHNVQVICKCY
What are the official names of this protein?
Uncharacterized membrane protein X69R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus X69R family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: HSB1_PICST
Sequence: MAPPKAEKKPASKAPAEKKPAAKKTASATDSKKRTKTRKETYSSYIYKVLKQTHPDTGISQKAMSIMNSFVNDIFERIASEASKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTRAVTKYSSASN
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B.1.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL18_METM7
Sequence: MAKNAKFRVPFRRRREGKTDFRQRLGLLLSGKPRLVARKSLNNVIAQLMAYDEKGDVVLVSAHSRELVKMGYKGHCGNLPAAYLTGLLLGKKAVKEGAEEAILDKGLHRATKGAAIFAVLKGALDAGMDIPHGDEIIADEERLNGTHVKNYAESLKEDADAYKKQFSKYLEKGLNPEDLPEHVEELKEKILNL
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: IKBN2_MDBVW
Sequence: MDSSDKSNLPLLLEIDWERHEAYTGENIFHVIAKKGWLKMLCALEGLVDEKIKPWLRKWSRDGNTCLHEAALRNKGPQAIRIMEKLIEYGADLNLKSSCHKPVLHVAVERNDYELVAWICQQPGINLEAEDFYKFTAHQLASKKNLNNDKKMVKILETYGAIPRQDGSSEDEVSDSEEKSDSE
What is the function of this protein?
Suppresses the host immune response through NF-kappa-B inactivation.  Possesses ankyrin repeat domains required for NF-kappa-B binding but lacks the regulatory regions required for dissociation from NF-kappa-B and degradation.  Therefore, prevents host NF-kappa-B release and subsequent activation.
What are the official names of this protein?
I-kappa-B like protein N2.
What is the protein family that this protein belongs to?
Belongs to the polydnaviridae I-Kappa-B like protein family.
Protein: MUG_SHIF8
Sequence: MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQLKPQEAQHLLDYRCGVTKLVDRPTVQANEVSKQELHAGGRKLIEKIEDYQPQALAILGKQAYEQGFSQRGAQWGKQTLTIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL331_MYCS2
Sequence: MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLEIKKFCPNCGTHQPHKESR
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: KDPB_PSEAE
Sequence: MNAQTQASKNALHKSLERRHNASTSLAALWRPALLQAFVKLDPRQLLRSPVMLVVELTAVLTTLLCFVPDQAVPTSVALQIALWLWFTVLFANFAEALAEGRGKARADSLKAGSQGLSANKRRADGSFESVVASSLRKGDVVRVQAGEMIPGDGEVIEGVAAVNEAAITGESAPVIRESGGDRSAVTGNTQVVSDWLLVRIGANPGESTLDRMIALVEGAKRQKTPNEVALDILLIGLTLIFLLVVVTLKPFALFAGGNLPLVFLVALLVTLIPTTIGGLLSAIGIAGMDRLVRLNVIAKSGRAVEAAGDVHVLLLDKTGTITFGNRRCSALYAAPGVSGKELAEGALLASLADDTPEGKSIVEYLRILHPIEEPRREELTPIAFSAETRLSGVDWNGQVYRKGAVDAALRFIDLPREKMPEVLSREVDKIAQSGGTPLLVVANGRLLGAIHLKDVVKPGIRERFAELRRLGIRTVMVTGDNPLTAAAIAAEAGVDDVIAEATPEKKLARIRQEQGEGRLVAMCGDGANDAPALAQADVGMAMNDGTQAAREAANLVDLDSDPTKLLDVVQVGKELLVTRGALTTFSIANDVAKYFAILPALFVGIYPQLDVLNVMRLQSPQSAILSAIVFNALIIVALIPLALRGVRVQAADASQLLQRNLLIYGVGGLVAPFLGIKAIDLLLTAVGLA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SDRP_THET8
Sequence: MTQVRETVSFKAGDVILYPGVPGPRDRAYRVLEGLVRLEAVDEEGNALTLRLVRPGGFFGEEALFGQERIYFAEAATDVRLEPLPENPDPELLKDLAQHLSQGLAEAYRRIERLATQRLKNRMAAALLELSETPLAHEEEGKVVLKATHDELAAAVGSVRETVTKVIGELAREGYIRSGYGKIQLLDLKGLKELAESRGQGR
What is the function of this protein?
Activates transcription.  The consensus DNA-binding site of this transcriptional regulator is 5'-WWGTGAN(5-7)ACACWW-3' in which W is A or T and N is G, A, T or C.  Regulated genes include those encoding proteins involved in nutrient and energy supply, redox control and polyadenylation of mRNA (PubMed:18699868).  Also regulates genes involved in oxidative stress response such as genes encoding manganese superoxide dismutase and catalase, and genes encoding a protein involved in nucleotide excision repair of damaged DNA and putative proteins involved in redox control, protein degradation and transcriptional regulation (PubMed:21054499).
What are the official names of this protein?
Transcriptional regulator SdrP, Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein SdrP, CRP/FNR superfamily protein SdrP, Oxidative stress-responsive transcriptional activator SdrP, Stationary phase-dependent regulatory protein, SdrP.
Protein: THI4_USTMA
Sequence: MTPPTASFINPATAGPQPGSFKLSKGSLHACSTTAAPKYEQYVPIKTGEEPIEDFNGHYRFAEIKESHTSRAMTARYMADMMDAAVSDVVIIGAGSAGLTCAYTLAKQRPDLRITMLEASVAPGGGAWLGGQLMSGMVIRKPAHNLLVEIGVPFDDEGSYVVVKHAALFTSTLMSKLLAMDNVKLFNATCCEDLIIKKDQTGAQRVNGVVTNWTLVTMAHGLQSCMDPQTITAPVVIGACGHDGPFGAFSVKRLSSAGLIKLGDMRPMDMNKSEGLIVNNTREVFPGLIVSGMELSEHDGHPRMGASFGGMIGSGQKAAYEAIKLYDSLEIDDGEVVGLKH
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.  May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
What are the official names of this protein?
Thiamine thiazole synthase, Thiazole biosynthetic enzyme.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BZPO_DICDI
Sequence: MDGYQNFLPIPPENNTWLLLLDDFSQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQFPQQYTNDGINVQSIESNNYLNNNNFNFNERLESLQKQQQEQQTQIQQQLQNYQQQYQDQYQQRQQQYQDQYQKPYELPSQYIDQCNQIFSNYNNNNNITSINYNMNNNNNSNNSNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKTTDNINNVNSINNLNNINLGANNVNNNVNSNVVSNVNNNAISQNKPIFPPFNDNPINIQQQQQQQQQQECYKIPQYKISLDNTNNPIITPTITPTLTTFPTITPTLITPTTIAPITPTPTPTPILTTTTTKTTKINLEETNEKTKIINETKKQEKSTESIKKMNQNKASRNYRQKKKDYIKEIEDKLSLLEMENSKIQKENQTLRKTGSVDLMKPSNDIMKMMTDCKTITNQLKLSLERNDDRSLIYLLHQYHRVIEERYSHIEYEAEKVANPYVQLRLSIVGYTPGQFCPFVLNIFNDNNDDGDNQKVTNDHNWYNTFKKEANITPEQSNKLDSIRFQHTKVSASMFKEIQMLDLEIKSFFYKFIFSYPSDPLSSLNPTELVYNSTTTTPIDSYSLPAIDKQLELAGKLESLKNKLTLNGGLMLDTFSSISSLLTPRQEAIFLVGVDPYAFINFSHFDIINDVWSNIINKPFSGPVHMAQSLNKMFNHS
What is the function of this protein?
Probable transcriptional regulator.
What are the official names of this protein?
Probable basic-leucine zipper transcription factor O.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OTSA_SALTS
Sequence: MSRLVVVSNRIAPPDNKGGAGGLAVGVLGALKAAGGLWFGWSGETGNEDEPLKKVTKGNITWASFNLSEQDYEDYYCQFSNAVLWPAFHYRLDLVQFQRPAWEGYMRVNALLADKLLPLIKENDIIWVHDYHLLPFASELRKRGVNNRIGFFLHIPFPTPEIFNALPPHDELLEQLCDFDLLGFQTENDRLAFLDSLSSQTRVTTRSGKQHIAWGKDFQTEVYPIGIEPDEIALQAAGPLPPKLAQLKAELKNVKNIFSVERLDYSKGLPERFLAYEALLENYPQHRGKIRYTQIAPTSRGEVQAYQDIRHQLETEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEFVAAQDPANPGVLVLSQFAGAANELTSALIVNPYDRDDVAAALNRALTMPLAERISRHAEMLDVIVKNDINRWQERFIHDLKEVTPRSPERQQQNNVATFPKLA
What is the function of this protein?
Probably involved in the osmoprotection via the biosynthesis of trehalose.  Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate.  Acts with retention of the anomeric configuration of the UDP-sugar donor.
What are the official names of this protein?
Trehalose-6-phosphate synthase, TPS, Alpha,alpha-trehalose-phosphate synthase [UDP-forming], Osmoregulatory trehalose synthesis protein A, OtsA, UDP-glucose-glucosephosphate glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 20 family.
Protein: TRHO_LISMF
Sequence: MSDYQVLLYYKYTTIDDPETFAKEHLAACKEMELKGRILVATEGINGTVSGTVEATNKYMDYMANDARFADMVFKIDAADAHAFKKMHVRPRAEIVSLSLEEDVNPLEVTGTYLEPSEFREALLDEDTVILDARNDYEFDIGHFRGAVRPDIQNFRELPGWIEDNREQLADKKIVTYCTGGIRCEKFSGWLKTAGFDDVSQLHGGIATYGKNEETKGELWDGQMYVFDERIAVPINQVNPTIVGKDYFDGTPCERYINCANPYCNKQILASIENEKKYLRSCSHDCRVHPANLYTKNLSKEEFTERLQAIDETLPEMVQ
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: RS20_AGRVS
Sequence: MANTTSAKKATRKIARRTAINKSRRTRVRNFVRKVEEAIASGDQALAAAALKAAQPELHRAASKGVVHANTASRKISRLASRVKALAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: UXS1_PONAB
Sequence: MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQENGELKIESKIEEMVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARIKKGRTRHN
What is the function of this protein?
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose.  Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
What are the official names of this protein?
UDP-glucuronic acid decarboxylase 1, UDP-glucuronate decarboxylase 1, UGD, UXS-1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: URE1_CERS1
Sequence: MPASISRSTYASMFGPTTGDRLRLGDTELVIEVERDLTTYGEEVKFGGGKVIRDGMGQSQRTRAEGAMDTVITNALIVDWTGIYKADVGLRDGRIAKIGKAGNPDTQPGVDIVIGPGTEIIAGEGRILTAGGMDAHIHFICPQQIEDSLHSGITTMLGGGTGPAHGTLATTCTPGPWHIGRMLQAADAFPINLAFAGKGNASLPAGLEEQVRAGASCLKLHEDWGTTPAAIDCCLSVADRMDVQVMIHTDTLNESGFVENTLAAIGGRTIHAFHTEGAGGGHAPDIIKVVGAANVIPSSTNPTMPYTANTVEEHLDMLMVCHHLDRSIPEDVAFAESRIRKETIAAEDILHDMGAFSVISSDSQAMGRVGEVITRTWQTAHKMKVQRGRLAEETGANDNQRVRRYIAKYTINPAIAHGLSRHIGSVEEGKRADLVLWQPAFFGAKPDLVLLGGMIVCAQMGDPNGSIPAQPYYSRPMFGAFGGALHASAVTFVSQAAEEDGVGERLRLQKGTLAVEGTRDIGKADMKLNAHRPSIEVNPETYEVRADGELLTCQPLAELPLAQRYFLY
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_BURTA
Sequence: MRTIDKRIAPNVKLATALVARAPTLTLAYDARCKSRLAATLDTGEEVALVLPRGTVLRDGDVLVADDGALVRVAAAHEAVLLVRAPDALTLTRAAYHLGNRHTPVEVGAGCLKLEYDPVLADMLTRLGATIERANAPFQPEAGAYGGGHRHGHDATFAEDYALAQQVFDEHHGRSHSHSHSHSHDHDHDHDHDHDHDHQHGPSCSHGHGHGHR
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.