PharMolix/UniProtQA huggingface dataset:
Protein: MAGD1_MOUSE
Sequence: MAQKPDGGAGLRGFQAEASVEDSALLVQTLMEAIQISEAPPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNATTKGPNDYSQARNAKEMPKNQSKAAFKSQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANEMTNNQPKTAKAWNDTTKVPGADAQTQNVNQAKMADVGTSAGISEADGAAAQTSADGSQTQNVESRTIIRGKRTRKVNNLNVEENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE
What is the function of this protein?
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells.  Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis.  May act as a regulator of the function of DLX family members.  May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.  Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.  Plays a role in the circadian rhythm regulation.  May act as RORA coregulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed.
What are the official names of this protein?
Melanoma-associated antigen D1, Dlxin-1, MAGE-D1 antigen, Neurotrophin receptor-interacting MAGE homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
Protein: H2A2_DEBHA
Sequence: MSGGKGKAGSSEKASTSRSAKAGLTFPVGRVHRLLRKGNYAQRVGSGAPVYLTSVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQSLLPAKKAKAGNASQEL
What is the function of this protein?
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.2.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: LOVC_ASPTN
Sequence: MGDQPFIPPPQQTALTVNDHDEVTVWNAAPCPILPRDQVYVRVEAVAINPSDTKMRGQFATPWAFLGTDYAGTVVAVGSDVTHIQVGDRVYGAQNEMCPRTPDQGAFSQYTVTRGRVWAKIPKGLSFEQAAALPAGISTAGLAMKLLGLPLPSPSADQPPAHSKPVYVLVYGGSTATATVTMQMLRLSGYIPIATCSPHNFDLAKSRGAEEVFDYRAPNLAQTIRTYTKNNLRYSLDCITNVESTTFCFAAIGRAGGHYVSLNPFPEHAATRKMVTTDWTLGPTIFGEGSTWPAPYGRPGSEEERQFGEDLWRIAGQLVEDGRLAHHPLRVVQGGFDQIKQGMELVRKGELSGEKLVVRLEGP
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR) (PubMed:10334994, PubMed:12929390, PubMed:21495633).  The first step in the biosynthesis of lovastatin is the production of dihydromonacolin L acid by the lovastatin nonaketide synthase lovB and the trans-acting enoyl reductase lovC via condensation of one acetyl-CoA unit and 8 malonyl-CoA units (PubMed:10334994, PubMed:10381407, PubMed:19900898, PubMed:22733743).  Dihydromonacolin L acid is released from lovB by the thioesterase lovG (PubMed:23653178).  Next, dihydromonacolin L acid is oxidized by the dihydromonacolin L monooxygenase lovA twice to form monacolin J acid (PubMed:12929390, PubMed:21495633).  The 2-methylbutyrate moiety of lovastatin is synthesized by the lovastatin diketide synthase lovF via condensation of one acetyl-CoA unit and one malonyl-CoA unit (PubMed:19530726, PubMed:21069965).  Finally, the covalent attachment of this moiety to monacolin J acid is catalyzed by the transesterase lovD to yield lovastatin (PubMed:10334994, PubMed:17113998, PubMed:18988191, PubMed:19875080, PubMed:24727900).  LovD has broad substrate specificity and can also convert monacolin J to simvastatin using alpha-dimethylbutanoyl-S-methyl-3-mercaptopropionate (DMB-S-MMP) as the thioester acyl donor, and can also catalyze the reverse reaction and function as hydrolase in vitro (PubMed:19875080).  LovD has much higher activity with LovF-bound 2-methylbutanoate than with free diketide substrates (PubMed:21069965).
What are the official names of this protein?
Lovastatin nonaketide synthase, enoyl reductase component lovC, Lovastatin biosynthesis cluster protein C, Trans-enoyl reductase lovC.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: SPEH_THEPX
Sequence: MNALGRHILAEIYGCDSNILDNLELIEDIMVQSAIVTGAEIREVAFHKFNPQGVSGVVVISESHITIHTWPELGYAAVDVFTCGDDVNPWDACNYIAKMLRAQNMTATEVKRGVFEKPVKVVNY
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: CYB_THOIS
Sequence: MTIMRKKHPLLKLINHSFIDLPAPSNISSWWNFGSLLGVCLMIQIMTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYLHANGASMFFICLFIHVGRGIYYGSYMLLETWNIGIILFLTTMATAFVGYVLPXXQMSFWGATVITNLLSAIPYIGNTLLEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPSGLNSNSDKIPFHPYYTIKDLLGVLLLLMVLMILVLFFPDILGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAAFPFLNSSKQHGLVYRPITQFLYWIFIANLLILTWIGGQPVEYPFTTIGQISSILYFTIIVVLMPVANMIENNILXLH
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPO11_HALWD
Sequence: MELRVIERTDTELRIEVAGEDHTFMNVIKGALLQTDGVAAATYDVNPEQSGGQTEPVLSIQTEPDADVDPLDALGDASRQVQTTVDDFTSAFTAAV
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit L.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_LISW6
Sequence: MKRKIIVGSRRSKLALTQSNWVINKLKEQYPEFDFEIKEIVTKGDRILDVTLSKVGGKGLFVSEVEQALSNSTIDFAVHSMKDVPSSLEEGLVIGAIPKRESPLDCFVFNQVSSLDDLPKGAIVGTSSLRRAAQLLKHRPDFNIRPIRGNIDTRLQKLHVENFDAIILAKAGLARMGWLENTTLKLEDIAPEVCLPAVGQGALAIECRESDQLIRDMLATIHHEETGICVEAERVFLKKLNGGCEIPIAGFATKIGEQIHFKGLVGNADGSKILESKEIGENPGQIGNKVAEVLLSEGAETIIEELRNK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: MCR1_NEUCR
Sequence: MSLFVASTRSAFRAAAPIKRSFQTRRSYATEPSKGGSSSTILLGAAAVGLAGAGAYFFSGAGAAKKAEASVKQVTEKITPGEIKKAFVGGDQGWLSLKLEEVELVNHNTKRLRFRLPEDDMVSGLHVASAILTKFKPIDAEKAVLRPYTPISDESAQGYIDLLVKKYEGGPMSTYLHDMAPGQRLDIKGPLPKYPWEANKHKHIALVAGGTGITPMYQLIRAIFNNPDDKTKVTLVFGNVSEEDVLLKHELATIENHYPQRFRAFYVLDNPPKEWAGNKGYINKDLLKTVLPEPKNEDIKIFVCGPPGMMNSISGNKKSPRDQGELTGILKELGYSPDQVYKF
What is the function of this protein?
May mediate the reduction of outer membrane cytochrome b5.
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: TSAD_VIBVU
Sequence: MRILGIETSCDETGIAIYDDEKGLLAHKLYSQIKLHADYGGVVPELASRDHVKKTIPLIKEALKEANLTAKDIDGVAYTAGPGLVGALLVGATIGRSLAYAWGVPAVPVHHMEGHLLAPMLEDNPPPFPFVAVLVSGGHSMMVEVKGIGEYKILGESIDDAAGEAFDKTAKLMGLDYPGGPLLSKLAEKGTPGRFKFPRPMTNVPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFEEAVCATLAIKCKRALEQTGMKRIVIAGGVSANRRLRAELEKLAHKVGGDVYYPRTEFCTDNGAMIAYAGMQRLKNNEVSDLAVEARPRWPIDQLTPVMK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_HAEIG
Sequence: MKLVEVKHPLVKHKLGVMREAEIDTKKFRELATEIGSLLTYEATSDLETEKVTINGWNGPVEIDRIKGKKVTVVPILRAGLGMMDGVLEHVPSARISVVGIYRNEETLEPVPYFQKLASDLEERLSIVVDPMLATGGSMIATLDLLKAKGCKHIKVLVLVAAPEGIKALEAAHPDIELYCASIDSHLNEQGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: M3H5_BOMMX
Sequence: MNFKYIFAVSFLIASAYARSVQNDEQSLSQRDVLEEESLREIRGIGGKILSGLKTALKGAAKELASTYLHRKRTAEEHEEMKRLEAVMRDLDSLDYPEEASERETRGFNQDEIANLFTKKEKRILGPVLGLVSDTLDDVLGILG
What is the function of this protein?
Maximin-H5 shows antibacterial activity only against the Gram-positive bacteria S. aureus.  The other bacterial and fungal strains tested were resistant to it.  The presence of metal ions, like Zn(2+) and Mg(2+), did not increase its antimicrobial potency.  Does not show hemolytic activity (in a concentration up to 80 uM).
What are the official names of this protein?
Maximins 3/H5.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: EMB8_PICGL
Sequence: MAISSRSVGMTEIHCNFPQNPFRRISRRISQFRAGFPDKKPAAGACEEQDELTSGSAARIQRRDKQLPEIIGSDRELMSKLTTLGRPYRHFPFMGNRHVETIFASFFRSWPVIKSRRECLRMEDGGTVELDWPLEGEDAELWNGELPVNSPVLILLPGLTGGSDDSYVKHMLLRARKHGWHSVVFNSRGCADSPVTTPQFYSASFTKDLCQVVKHVAVRFSESNIYAVGWSLGANILVRYLGEVAGNCPLSGAVSLCNPFNLVIADEDFHKGLGFNNVYDKALARGLRQIFPKHTRLFEGIEGEYNIPTVAKARSVRDFDGGLTRVSFGFQSVGDYYSNSSSSLSIKYVQTSLLCIQASNDPIAPSRGIPWEDIKENPNCLLVVTPNGGHLGWVAGDDAPFGAPWTDPLVMEYLEVLEKNQIEKPLRRTIDDVHTPRVDSVHTRETNNYKSPIENVN
What are the official names of this protein?
Embryogenesis-associated protein EMB8.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
Protein: GCST_BURL3
Sequence: MTALNHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFTGSRVRAFFEHAIANNVGKLKTPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQGGFGVTITPRRDFAIVAVQGPNAREKAWSTVPAARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQNGVRPCGLGARDTLRLEAGMNLYGQDMDDTVSPLDAGLAWTVDLTAPRDFVGRAALEANGTRAAFVGLILQKENGKAGGVLRAHQKVVTPHGEGEITSGTFSPSMQESIAFARVPAAVQIGDLVQVQIRDKNLPARVVKLPFVRNGKVLAA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: HSP1_HYLLA
Sequence: MARYRCCRSQSRSRCYRRGQRSRRRRRRSCQTRRRAMRCCRPRYRLRRRRH
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1, Cysteine-rich protamine.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: GRM_MICEC
Sequence: MTTSAPEDRIDQVEQAITKSRRYQTVAPATVRRLARAALVAARGDVPDAVKRTKRGLHEIYGAFLPPSPPNYAALLRQLDSAVDAGDDEAVRAALRRAMSVHVSTRERLPHLAEFYQEIFRHVPQPNTLRDLACGLNPLAAPWMGLSDQTVYVASDIDARLIGFVDAALTRLGVAHRTSVVDLLEDRLDEPTDVTLLLKTLPCLETQRRGSGWEVIDIVNSPIIVVTFPTKSLGQRSKGMFQNYSQSFESQARERSCRIQRLEIGNELIYVIQK
What is the function of this protein?
Specifically methylates the N(7) position of guanine 1405 in 16S rRNA.  Confers resistance to various aminoglycosides, including gentamicin and kanamycin.
What are the official names of this protein?
16S rRNA (guanine(1405)-N(7))-methyltransferase, 16S rRNA m7G1405 methyltransferase, Gentamicin-resistance methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Aminoglycoside resistance family.
Protein: SGCR_ECOLI
Sequence: MSQQRPDRIKQMLHYLWQHRHLSTQQAMELFGYAEATVRRDFQYIVNQYPGMIRGHGCLDFDDSTDDKEYVFDVKRTLQSVAKREIAALARTMIKDGDCFFLDSGSTCLELAKCLADARVKVICNDIKIANELGCFPHVESYIIGGLIRPGYFSVGESLALEMINAFSVERAFISCDALSLETGITNATMFEVGVKTRIIQRSREVILMADHSKFDAVEPHAVATLSCIKTIISDSGLPETIAQRYQRAGCQLFLPHSIK
What is the function of this protein?
Putative transcriptional regulator for the sgcREAQCX region.
What are the official names of this protein?
Putative sgc region transcriptional regulator.
Protein: RL6_STAAR
Sequence: MSRVGKKIIDIPSDVTVTFDGNHVTVKGPKGELSRTLNERMTFKQEENTIEVVRPSDSKEDRTNHGTTRALLNNMVQGVSQGYVKVLELVGVGYRAQMQGKDLILNVGYSHPVEIKAEENITFSVEKNTVVKVEGISKEQVGALASNIRSVRPPEPYKGKGIRYQGEYVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ADH_DROMA
Sequence: MAFTLTNKNVIFVAGLGGIGLDTSKELVKRDLKNLVILDRIENPAAIAELQAINPKVTVTFYPYDVTVPIAETTKLLKTIFAKLKTVDVLINGAGILDDHQIERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVEPQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLSTLEAIQWTKHWDSGI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: EFG_YERPP
Sequence: MARKTPIERYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTCFWSGMAKQFEPHHVNIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLRVVGQLKSRLGANPVPLQLAIGAEEKFTGIIDLVKMKAINWNEADQGVTFEYEEIPADMAELAAEWHQNLVESAAEASDELMDKYLGGEELTEEEIKKALRQRVLKSEIILVTCGSAFKNKGVQAMLDAVIEYLPAPTDVESINGILDDGKDTPAVRHSDDKEPFSALAFKIATDPFVGNLTFFRVYSGIVNSGDTVLNSVKSQRERLGRIVQMHANKREEIKEVHAGDIAAAIGLKDVTTGDTLCDPNNPIILERMEFPEPVISVAVEPKTKADQEKMGMALGRLAKEDPSFRVWTDEESGQTIIAGMGELHLDILVDRMRREFNVEANVGKPQVAYRETIRETVKDVEGKHAKQSGGRGQYGHVVIDMSPLPPGGVGYEFVNEIVGGSIPKEFIPAVDKGIQEQLKSGPLAGYPVVDVKVRLHYGSYHDVDSSELAFKLAGSIAFKEGFKRAKPVLLEPIMKVEVETPEDYMGDVMGDLNRRRGIIEGMEDTATGKTVRVKVPLSEMFGYATDLRSQTQGRASYSMEFLEYAEAPSNVAKAVIEARGK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU2M_NATST
Sequence: MNPLIFSTILATIIMGTAIVMTSSHWLTIWIGFEMNMLAIIPMLMKQHNPRSTEAATKYFLTQATASMLLMLAVIMNLTHTGQWTITKSFNPLASIIMTIALTMKLGLSPFHFWVPEVAQGIPLSSCLILLTWQKLAPLSILYMISPTINLNLLLSMSLISVAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAILAYNPTMTMLNLLVYITMTTTMFMLLIKSASTTTLSLAIMWNKVPLVTTLTLTIMLSLGGLPPLTGFLPKWMIIQELTKNNNIIMPTLMAIMALLSLYFYMRLTYATTLTMFPTTNNMKMKWQFEPKKHMNLLSPLIVMSTLTLPLAPMMSLLD
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NUOD_SALRD
Sequence: MPQTQKPDFPGNDLGDQFRFWPKHNEKIYERLENKHAWLEEKRAAAQGDGKPPATQRSEVDPLENEMILNIGPQHPATHGVLRCVVKMDGETIEKSVLDIGYLHRGIEKLAEHKTYQEFMPYTDRMDYLSPYSNNVAWCLAVEKLADIEVPERAQWIRMIMSELARISSHCLWLGVGMMDAGAVSGFVWTFQEREEIYSIMDEVAGARFTVSHSRIGGVANDFSPRAIEMIRDFVDTFPDRIAGWEGLLNKNRIWVERNKGVGRVTKEEALELGLTGPNLRGSGVPYDVRRFEPYLKYDEVDFTIPVREEGDCLARYFLRLDEMKQSVRIIEQCLDRMTEGPIRSDDAKEAYPSKEEVYYSMEGMIHDFMYTDVGTVPPKGAHSYHAIEGPKGELGFYLTSDGTGRPWRVRINAPSFTNLQAMEHMLEGEMVADTVVIIGSLDPVMGEADK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NDPA_ECODH
Sequence: MSLDINQIALHQLIKRDEQNLELVLRDSLLEPTETVVEMVAELHRVYSAKNKAYGLFSEESELAQTLRLQRQGEEDFLAFSRAATGRLRDELAKYPFADGGFVLFCHYRYLAVEYLLVAVLSNLSSMRVNENLDINPTHYLDINHADIVARIDLTEWETNPESTRYLTFLKGRVGRKVADFFMDFLGASEGLNAKAQNRGLLQAVDDFTAEAQLDKAERQNVRQQVYSYCNEQLQAGEEIELKSLSKELAGVSEVSFTEFAAEKGYELEESFPADRSTLRQLTKFAGSGGGLTINFDAMLLGERIFWDPATDTLTIKGTPPNLRDQLQRRTSGGN
What are the official names of this protein?
Nucleoid-associated protein YejK.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: YR405_MIMIV
Sequence: MESINDVSEICLQLVNLNYSDQLDFKLNLIKQYIPNLLTNQVIASPLVDNYRNKLRFDIGLSNHDLITIGYSLPKKKNTHRYVYSSISMKHLHPKMIQIVSKIELFLRTHEQSWYSIKHGETLLPSMTIRTSFHTEDVMIIFKFKGPQNETVINYFSSDIFYEIIESIEINIVIEFSDCRKIVKGHNYIHEKLDDYIFKITDESFFQVNTLATEVLYNKVLELTMKYIKPTGQDILFDLCCGTGTIGIYLSKIFTKVFGIDIKQSSIIDANHNKLLNNIPNIEFICNPIENVLEKLISECLEKNPDSTFFAVVDPPRTGMHGGVQNTINNCPNLEYLIYVSCNVVTFKRDMEILGKQFEAIETICLDLFPHTPHCELIVVLKKIDLSIY
What are the official names of this protein?
Putative RNA methyltransferase R405.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: HERA_METJA
Sequence: MYVMKVVGKTTTTHFTFESLEKIRFGEYVIAKNVDGRDVLGVIKNVVADVEKFVGEVKVIGVLDGNKIIPNRTPILPNSEVRLCDDEILNNIYLTPDGLNIGHLLTRDNVRVYLDTNKLVSRHFAILSITGGGKSNTASVLCRELAKKNGTVIMIDPHGEYISLYHEDMEGKIKVINPIINPVLLAPSEFANLIGIGDNEIEKRVYVEFAYHTVKHECPDAKGIEFIEKIENLLYEWSKIASVGWEIKYYNPLRRNYDRRKLEKEDFVILMSLIDTISKFKLDYALNIGDRDVIEEFEIGKINIVNLSGLEIPQMVTFVGFIAKHLLLKRITYLKSLKDVYSINEEIRRVAQSNLNIIESHYKVVTKPVLLIVEEAHIFIPVNEQNSASLWLGKIAREGRKFGVGLGLVSQRPKQLHPDVLSQTNTKIILKIVEPEDQKYIQRASEELGEDLVKDLASLGIGEAVIVGAAISLPSIVKIDKFDGVYGGKDINIVGEWMGLDDW
What is the function of this protein?
Involved in DNA double-strand break (DSB) repair (By similarity).  Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity).  Exhibits DNA-dependent ATPase activity and DNA helicase activity (By similarity).
What are the official names of this protein?
Probable DNA double-strand break repair helicase HerA.
What is the protein family that this protein belongs to?
Belongs to the HerA family.
Protein: Y1075_AQUAE
Sequence: MEKTYKLPIVLGTDPENTIRIDKLPPLKGAFAVHIHESETENNAHIKLEYGDTEYCLSLYVFNYPKFLRNETVRVRNYDLWPKWIMFAARLPNGKLHPKSGGKVYREDAVIVGEGNYELENPFISFKYSDGRILNFRIEFYRYLRYKSPKYGPSFRSEYWFIGVD
What are the official names of this protein?
Uncharacterized protein aq_1075.
Protein: FLIW1_HELAH
Sequence: MLFDVKVPILGFETIHKMRLQKIDEIFLRLSSAEENSVVSFTLVNPFALRKYEFEVPTPLKILLELEEAKSVLVANIMVVQTPIELSTVNYLAPLIFNFDKQLMGQVVLDSNKYPHYHLRENILSHTHE
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW 1.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_ESCF3
Sequence: MIGRLRGIIIEKQPPLVLIEVGGVGYEVHMPMTCFYELPEAGQEAIVFTHFVVREDAQLLYGFNNKQERTLFKELIKTNGVGPKLALAILSGMSAQQFVNAVEREEVGALVKLPGIGKKTAERLIVEMKDRFKGLHGDLFTPAADLVLTSPASPATDDAEQEAVAALVALGYKPQEASRMVSKIARPDASSETLIREALHAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.