PharMolix/UniProtQA huggingface dataset:
Protein: UGPA_BRUA2
Sequence: MQKVTFPNKILPYFLLAPQIVLTVVFFFWPASQAIYQSFMREDAFGLKSTFVELANFTAVLSDPNYLHSVQVTVVFNVLTALLAMGVALLLATAADRVIRGQTFYRTLLIWPYAVAPAVAGMLWLFIFNPAMGTFAYLLRRNGIAWDPLLDGNQAMGLVVVAAAWKQISYNFLFFVAGLQAIPKSLIEAAAIDGARGARRFWTIVFPLLAPTSFFLLVVNTVYAFFDTFGIIHAVTGGGPAKATETLVYKVYNDGFVNLNLGSSSAQSVILMAIVIALTAFQFRFVEKRVHYS
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpA.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECF_OPITP
Sequence: MRLRHLTLRHFRNVGFAALAFSGRQQFLVGLNGQGKTNLLEAAGFLTALRSFRTTDNKLLIQHGQHTGAISSELTHEQLGDTKLTIKLRRDGKELWSDATRVTRLADHLGRFPTVVFSSQDLHLVRGAPALRRRWLDLTLASMDAGYLRALQTYSRALADRNALLKRGNAADAELDAFEQQLAPAAVALLATRTAALALLGAKLAVAYDRLCAGDAAEKVGLHYEPSFDGPSTEAWLARFESSRGRDAQFRTTLVGPHRDDFSFVVRGTAAKDFASEGQQRSLVLALRLAQAEWGHEKSGTRPVLLADDVLGELDPLRRRRFWASIDPESQILATGTSLPDAELGEWQVFEVKSGEFEAAAETPEL
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_CAMJD
Sequence: MRALALDIGLKRIGVALCVDKKIALPLDAVLRKNRNQAANEIKNLLKIHEISLLIVGIPKGGSSEEEMTRRIKHFVSLLEFDKEICFVDESGTSKKALEYGIANTRKKDGKLDSLAAFIMIKDYFCSLE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_MYCUA
Sequence: MSWWQVISLAVVQGLTEFLPVSSSGHLAVVSRVFFSDDAGASFTAVTQLGTEAAVLVYFARDIVRILRAWFDGLVVKSHRNADYRLGWYVIIGTIPICVLGLLFKDEIRSGVRNLWVVATALVVFSGVIALAEYLGRQSRHVEQLTWRDGLVVGVAQTLALVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVVGLAAVSWFLRFLLRHSMYWFVGYRVVVGVVVLILLATGTVAAT
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MZT2_BOVIN
Sequence: MAAAGAGPGPGPGAPPGLEAALQKLALRRKKVLSAEEMELFELAQAAGGAMDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRVASDSQDPTAAPLPTPSVPETRGRNKGGGALGGGPALAERGGRDGPGQRMPRQPSASRLPKGGGPGRSPPRSGT
What are the official names of this protein?
Mitotic-spindle organizing protein 2, Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2.
What is the protein family that this protein belongs to?
Belongs to the MOZART2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
Protein: UCSF_ACRSP
Sequence: MGVPLLDVSQLQAGPEARKQYLQALVQSFRDYGFVRLTKHDVPAKRVQRIFDLSTQMFNLDIDSKLEFANIADGSPQRGYSAVGVEKTASLHGNLIGRRVDEKLTDAREHFDCGSPLDKSFANRWPEKLQGFQQELESFYFELEQVTAGILGSLEEALNCPPGTLNNMITKENNASELRLNHYPPVPAGTLRNGNVARIWPHFDLGVITLLFTSAVGGLEVEDRNAPGPQTFIPVEPETEAELIVNISETLQRWTDDHLPAGLHRVTIPKDLDTEIQNDANVEIPGRYSIAYLCKADREADVGTLPVFQTGEAPRYKAMTASEYHRSRLLTAY
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that acts as a strong telomerase inhibitor and displays potent antibacterial and antitumor properties (PubMed:29373009).  These compounds share a hemiaminal-containing pyrrolizidinone core fused with a gamma-lactone, giving a furopyrrolizidine that is connected to a decalin fragment (PubMed:29373009).  The polyketide synthase module (PKS) of the PKS-NRPS ucsA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:29373009).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with a 2S,3S-methylproline derived from L-isoleucine by the 2-oxoglutarate-dependent dioxygenase ucsF which converts L-isoleucine to (4S,5S)-4-methylpyrroline-5-carboxylate that is further converted to 2S,3S-methylproline by the pyrroline-5-carboxylate reductase ucsG (PubMed:29373009).  Reductive release of the completed aminoacyl polyketide from the assembly line can form the 3-pyrrolin-2-one structure via an intramolecular Knoevenagel reaction (PubMed:29373009).  Because ucsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase ucsL (PubMed:29373009).  This keto acyclic precursor is the substrate of the Diels-Alderase ucsH, that catalyzes the Diels-Alder cycloaddition (PubMed:29373009).  Oxidation of the 3S-methyl group to a carboxylate by the cytochrome P450 monooxygenase ucsK allows an oxa-Michael cyclization that might involve the reductase/dehydrogenase ucsI and which furnishes the furopyrrolizidine (PubMed:29373009).  The oxidase ucsJ likely plays a critical role in stereoselective reduction of the C5-C6 double bond to afford the required R-configured carboxylate group (Probable).  Further enolization and oxidation at C5 by an unidentified enzyme affords the last intermediate that can undergo oxa-Michael cyclization to yield UCS1025A (Probable).
What are the official names of this protein?
2-oxoglutarate-dependent dioxygenase ucsF, UCS1025A pyrrolizidinone biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: TM86A_HUMAN
Sequence: MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSTLIKCLPIFCLWLFLLAHGLGFLLAHPSATRIFVGLVFSAVGDAFLIWQDQGYFVHGLLMFAVTHMFYASAFGMQPLALRTGLVMAALSGLCYALLYPCLSGAFTYLVGVYVALIGFMGWRAMAGLRLAGADWRWTELAAGSGALFFIISDLTIALNKFCFPVPYSRALIMSTYYVAQMLVALSAVESREPVEHYRLTKAN
What are the official names of this protein?
Lysoplasmalogenase-like protein TMEM86A, Transmembrane protein 86A.
What is the protein family that this protein belongs to?
Belongs to the TMEM86 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BIOB_ACICJ
Sequence: MSIALDSSTATAAAAPSPTRARIAALLALPLPELIFQAQTVHRQHFDPTQVQISTLLSIKTGGCPEDCGYCPQSAEFDVGVKASKLMDIAPVLEAARRAKEAGAQRFCMGAAWRSPKDHDLDRVAAMVEGVKALGMETCVTLGMLRPDQAARLKSAGLDYYNHNLDTSPEFYGSIITTRTYQDRLDTLAAVRDAGINICCGGIIGMGEDLDDRAGLLATLADLDPPPESVPINALVAVKGTKLGESAPIDPIDFVRTIAAARISMPRSWVRLSAGREALSDEAQALCFLAGANSIFYGDTLLTTANPAVARDNALFDRLGMTKLS
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: PNP_BORPA
Sequence: MFNKVTKTFQYGQHSVVLETGEMARQASGAVLVSVEDTVVLATVVAAKKAKAGQDFFPLTVDYIEKTYAAGRIPGGFFKREGKPSEKETLTSRLIDRPLRPLFPEGFYNDVQVVIHTLSVNPDIDPDIPAMIGASAALAISGIPFNGPIGAARVGYVDGQYVLNPTATQLKSSKMDLVVAGTENAVLMVESEAKQLSEEIMLGGVVFGHEQMQAAINAIHDLVRDAGKPDWDWQPAPKNEALIAAVSAAAQEGLNAAYQIREKQARTTKLREVYAAVQAAMAEQAAQAGQPAPDSVGVDNILFDLEARIVRSQILNGEPRIDGRDTRTVRPISIRLGVLPRAHGSALFTRGETQALVVATLGTKQDEQIIDALMGEYRDRFMLHYNMPPFATGETGRIGVPKRREIGHGRLAKRALLPLLPAPEDFQYTIRLVSEITESNGSSSMASVCGGSLAMMDAGVPTNDHVAGVAMGLILDSGKFAVLTDILGDEDHLGDMDFKVAGTETGITALQMDIKIQGITKEIMQVALAQAREGRLHILGKMRDALEGSRTELSAFAPRMLTIKINPEKIRDVIGKGGATIRALTEETGTQIDISDDGTIVIASVDETQAKEAQRRIVELTADVEVGQIYDGSVLRLLDFGAIVQVLPGRDGLLHISEIANYRIANINDVLKVGQPVRVKVIEADDKGRLRLSIKAIGGIEQQQSGTAEPAAQSEPQAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_OCHPY
Sequence: MEEFQVYLELNRSRRHDFLYPLIFREYIYALAHDHGLNKSMIFFENQGYGNKFSSLIVKRLIIRMDQQNHLIISANDSNQNPFFGHNNNLYSQMISAGFAVIVEIPFSLRLVSYSQGEEVAKSHNLQSIHSIFPFLEDKFSHLNYVLDVLIPHPIHLEILVQALRYWVKDASSLHLLRFSLYEYCNLKSFITPKKSISIFNPRLFLFLYNSHACEYESIFLFLRNQSSHLRSTSSGAFLERIYFYGKIEYLVEVFYNDFQNNLWLFKDPFIHFIRYQGKAILASKDTSLLMNKWKYYFVDLWQYYFYMWSQSGRVRINQLSKYSLDFLGYLSSVRLNPSVVRSQMLENSFIIDNAMKKLDTRIPIISLIGSLSKAKFCNTLGHPISKPTWADSSDSDIIDRFVRICRNLSHYHSGSSKKKSLYQIKYILRFSCVKTLARKHKSTVRAFLKRLGSEFLEEFFTETEEEHVFSLIFPRVFFTSRKLYRGRIWYLDIICINALVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: VM2AB_ERIMA
Sequence: ELLQNSGNPCCDPVTCKPRRGEHCVSGPCCDNCKFLNAGTVCWPAMGDWNDDYCTGISSDCPRNPVFK
What is the function of this protein?
Extremely potent and selective inhibitor of integrin alpha-5/beta-1 (ITGA5/ITGB1).  Partially inhibits adhesion of cells expressing alpha-IIb/beta-3 (ITGA2B/ITGB3), alpha-V/beta-3 (ITGAV/ITGB3), and alpha-4/beta-1 (ITGA4/ITGB1) to appropriate ligands only at concentration higher than 500 nM.  Weakly inhibits ADP-induced platelet aggregation.
What are the official names of this protein?
Disintegrin EMF10B, EMF-10B, Eristocophin II, Platelet aggregation activation inhibitor.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIe sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPG_RICTY
Sequence: MSNLKQLRTRIKSVKSTQKITKAMQLVSASKMTKIKTQIANSNFYIEAINKMMSNIFSMTLCELSIEEQKFFNTMPSKANLLIVMTSERGLCGMFNYSIIKQVKNDIKELANKGEQIKLIIIGKKGYEVLKRQYANYIDSYFEFPKSHYANLILQLKEKIMYAVENLEISNCIIYFNKFKNAMTQILTKQKILPIEKHRDYSVVENYHFEYEGKNLISNLINLYLYAKINYALLQNIVSEEGARMTAMDSATNNANDLISKLVLKLNRSRQTIITTELIEIIAGAEAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NSP4_ROTH5
Sequence: MEKLTDLNYTLSVITLMNNTLHTILEDPGMAYFPYIASVLIVLFTLHKASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLTLAGYKEQITTKDEIEKQMDRVVKEMRRQLEMIDKLTTREIEQVELLKRIYDKLMVRSTGEIDMRKEINQKNVRTLEEWENGKNPYEPKEVTAAM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: Y486_MYCBO
Sequence: MLVLLVAVLVTAVYAFVHAALQRPDAYTAADKLTKPVWLVILGAAVALASILYPVLGVLGMAMSACASGVYLVDVRPKLLEIQGKSR
What are the official names of this protein?
Uncharacterized protein Mb0486.
What is the protein family that this protein belongs to?
To M.leprae ML2453.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DRC4_MOUSE
Sequence: MAPKKKGKKGKAKGTAIVDGVAPEDMTKEQVEEHVARIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLAEVKAEGTVVMKLAQKEHRTQEGALRKDMRVLKVELKEQELANEVVIKNLCLKQAEEITKMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEIHEVEERKNGQISTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEEHMEREMAEVTLQNRRLADPLQKAKDEMNEMQKRLGNHERDKQILVCTKARLKVAERELKDLKWEHEVLEQRFIKVQQEREELYRKFADAIQEVQQKTGFKNLLLERKLQALNAAVEKREVQFNEVLAASNLDPTALTLVSRKLEDVLESKNTTIKDLQYELARVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGAPT
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.  Plays an important role in the assembly of the N-DRC linker (By similarity).  Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement.  Required for proper motile cilia functioning.  Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (PubMed:17366626, PubMed:21659505, PubMed:27472056).  May play a role in the spermatozoa motility (PubMed:11751847).
What are the official names of this protein?
Dynein regulatory complex subunit 4, Growth arrest-specific protein 11, GAS-11, Growth arrest-specific protein 8, GAS-8.
What is the protein family that this protein belongs to?
Belongs to the DRC4 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Associates with microtubules (PubMed:17366626). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (PubMed:11751847).
Protein: GNGF_THETU
Sequence: MKNFAYLNGPKVVVIGGGTGLSTMLRGLKKYTHNITAIVTVADDGGGSGVLREDLGMLPPGDIRNCILALRNTEPTMEKLLQYRFTDGMLKGQSFGNLFLAAMNGISISFEEAVKKMSEVLAVSGKVLPVTLDDVKLKAKLKNGIVIDGESLIPKLQMKEKSPIERIFLEPKDAKPVKEALIDIMDADEIILGPGSLYTSIIPNLLVNDVCEAIEDSKAIKVYVCNIMTQPGETIGYDANAHVDALFLHGLKSLDYVIVNNGEIPYEYKDRYKEDMSQPVSYDVESFKQKGIKVIEKDVLAIRNNYIRHDEQKLAEILMGLLE
What is the function of this protein?
Required for morphogenesis under gluconeogenic growth conditions.
What are the official names of this protein?
Putative gluconeogenesis factor.
What is the protein family that this protein belongs to?
Belongs to the gluconeogenesis factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HQD2_CANAL
Sequence: MSQAFTESVKTSLGPNATPRAKKLIASLVQHVHDFARENHLTTEDWLWGVDFINRIGQMSDSRRNEGILVCDIIGLETLVDALTNESEQSNHTSSAILGPFYLPDSPVYPNGGSIVQKAIPTDVKCFVRGKVTDTEGKPLGGAQLEVWQCNSAGFYSQQADHDGPEFNLRGTFITDDEGNYSFECLRPTSYPIPYDGPAGDLLKIMDRHPNRPSHIHWRVSHPGYHTLITQIYDAECPYTNNDSVYAVKDDIIVHFEKVDNKDKDLVGKVEYKLDYDISLATESSIQEARAAAKARQDAEIKL
What is the function of this protein?
Can cleave 4-methylcatechol at lower rates than catechol, but has no activity with 3-methylcatechol, 4-chlorocatechol, 4-carboxycatechol or hydroxyquinol.
What are the official names of this protein?
Catechol 1,2-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the intradiol ring-cleavage dioxygenase family.
Protein: CHMP3_HUMAN
Sequence: MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVCIVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDRILFEITAGALGKAPSKVTDALPEPEPPGAMAASEDEEEEEEALEAMQSRLATLRS
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.  Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested.  Involved in late stages of cytokinesis.  Plays a role in endosomal sorting/trafficking of EGF receptor.  Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
What are the official names of this protein?
Charged multivesicular body protein 3, Chromatin-modifying protein 3, Neuroendocrine differentiation factor, Vacuolar protein sorting-associated protein 24, hVps24.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane. Note=Localizes to the midbody of dividing cells.
Protein: MKT1_SCHPO
Sequence: MTIRSLNLFIIDKKHQHKSSLSSFQNCKLGIDASFYLTQIIHSFTPQELQSLAVNGESEYLQHRISEFLEQLRTENITPIFVFNGIPLTFEASSQLEVPGKQKSHSALTDFEAFDPYDANIQRNMYRMDASGPANYGESKPTLLYTNQRDHLDRLCDQVKFYLDQCNVEYFVAPYLAMAQLAYFLNGTSSPYIDAIYGSTDLLLFGVKKFITSMNTSSNVKISSDPSSPSTQTTINSAAKSSFTWLDGNALLQDTNGLSWQQFIDSCLLCGTAISPTFPQIEGTFLIKSAMELVRMFGSAYRAVLHFAEIFPQPIFQDYLQQYKRAVCFSKFGIVMDTKGLTLPPVPTESVPNDINIYFGTRLPNEIYFYISRGLIPCKMIGALVSGCFSDPVSILEQHIGDKASQGTFSGANSGLNPGRDNAAAVAAVDQRRFVDDLEEIWSQGLNLLTQPLNRFYQARDIVSLHGHNQQASLKVMHSYDPPLYNDTRAWMIYEENLPSYLSSNFLKEEPVVLFDLLRALNDPVFVKKSFCTEGNIGIKNPPKHPLSSTAEIVLSSCYRFLQIRSFVLTSHQLTSWGCPLLKALENCHLQNQTSVVVLFELLRLRQLKEPSLLSSSSASIADLSITSATEFLAKVATFLPIKQRPEVSKISIVDENLLQFYQLQTSFGSNLKELMAMILASVILNRNVDKSKIDPKLIRKTLPFQNINGSLVSGFVVKRFFEIISKEQEASSQQENIQKAYEIIEKEFPTIGSAENHIAQFLEFWKTFMEGVKEAENTSAIGKLVLSKLFLTNQWIFSLGL
What is the function of this protein?
Involved in post-transcriptional regulation of gene expression by 3'-UTR-mediated RNA regulation (PubMed:31822915).  Promotes interactions between mRNA and poly(A)-binding protein (PubMed:31822915).  Binds the 3' UTR of mRNAs, centromeric transcripts and antisense-rDNA (PubMed:31822915).  Required for the establishment but not the maintenance of heterochromatin at pericentromeres, and for the maintenance of small domains of facultative heterochromatin known as HOODs (PubMed:31822915).
What are the official names of this protein?
Post-transcriptional regulator mkt1, Inactive endonuclease mkt1, Post-transcriptional RNA stability regulator mkt1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family.
Protein: YRVN_BACSU
Sequence: MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILYGPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRLDKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALERALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITLETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIARRLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAILAIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPLKNKQYYKPKQTGKFESALKQVYDKLMKRK
What are the official names of this protein?
Uncharacterized AAA domain-containing protein YrvN.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
Protein: DAPF_METKA
Sequence: MQFWKVHGARNDFVLVDETEEEVVPESDKPDFARWACDRRSGVGADGVVFIRSDPPSVEMRIFNRDGSEAEFCGNAARCVVKYVTEVRGENVKILRTLSGAHRVEVQGGWIAVEVPEAEIKKVVELGYEVDAGVPHFVRLTERDPIHDFGGLTDEAKTIFSEYEPKGGVNVTYAAPSVDELRVRTFERGVGWTPACGSGVVAASLVYSEIFGPFEEVSVRTAGGCLRVSLSDGPLLIGRAEIVYKGELRGDWRENTDHQRRRHSLSRSPSGRPRLQECR
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C621_CONCL
Sequence: MQLTHVLVVGLLVLTSFQPINAVTNRVDCSAPEDKSEPGYWCGLEPLCCYSGKCFVICFGSKPAGT
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
Conotoxin Cal6.21, O1_cal6.21.
What are the subcellular locations of this protein?
Secreted.
Protein: ACDC_MYCTU
Sequence: MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSELWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSPAINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSPERQFQVFLDDVRLPADALVGAEDAAIAQLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY
What is the function of this protein?
Has acyl-CoA dehydrogenase activity on a number of substrates.  N-octanoyl-CoA is the best tested, but n-lauroyl-CoA, n-palmitoyl-CoA and isovaleryl-CoA were also used.
What are the official names of this protein?
Acyl-CoA dehydrogenase FadE12, Medium chain acyl-CoA dehydrogenase, MCADH.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.