PharMolix/UniProtQA huggingface dataset:
Protein: RIMM_SHEB8
Sequence: MSSNQQPVVLGKLGSCHGIKGWLKITAYTDSVEGIFDYSPWLIKENGEWREIKVTQWRYQGKAVVALLDGVETREQAQMLTNCEIAILPEQMNDLPADEFYWRDLIGCEVVNTTGYNMGIVDQIVETGSNDVLLVKANAKDSFGKVERMIPFVPEQFIKTVDLQGKQILVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_THEFY
Sequence: MAKSLTAAELRGYSVKELTEKLKEAKEELFNLRFQAATGQLDNNSRLRIVKREIARIYTVLREHELGIMPLAAEESADKAKEAAE
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: LOLD_RICFE
Sequence: MNNTVLILKNISKHYSQGKTIVRVLDDLNLTVNEGELIAIIGSSGSGKSTLLHIAGLLDKPTNGQVIIPNSKYQKYHLIRLHYLGFIYQQHHLLKDFTALENVIMPRLISGLDQKEAIEDATKILDDLGLGKKLYNMPGELSGGEQQRVAIARSLINKPKIILADEPTGNLDPKTTNEVFNLFLKVAREQNTAVIMVTHNHELAHKMDKLYKLKHGLLNIA
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GPPA_SALTY
Sequence: MNSTSLYAAIDLGSNSFHMLVVREAAGSIQTLTRIKRKVRLAAGLNNDNHLSAEAMERGWQCLRLFAERLQDIPQPQIRVVATATLRLAVNAGEFIAKAQTILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFSDRNLAQENFDDAEKAARDVLRPVADELRFHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFTELNIQSMTLAGGALREGLVYGMLHLAVDQDIRSRTLRNIQRRFIVDTDQANRVAKLADNFLKQVENAWHIEPISRELLLSACQLHEIGLSVDFKQAPYHAAYLVRHLDLPGYTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAILFAGRRRDDLVPEITLQALNENLTLTLPGDWLAHHPLGKELIDQESQWQSYVHWPLDVR
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: RQL5_ARATH
Sequence: MDFDSDSDGSHVSATPPRDSFPSSPPQLQSPAKHVPPVSRKMTSSSSRSKPKAPTHPPPNPSQEAPVPSPYPPPPPPSPLFTNLPFRICQSQPARFSSSVSSFSRLCSRASFTSVEKLKSDGVDFVPEPPLVEVIAPPKSVRRKPPNLITDTITSPPVKPMVFRSNGNGEGNFVKLNLNGKRGKKFPSKYKGVSKSRSSYSFRGKRYKKKEADGDGESLLEEESDLQKQIEDEANGFISSVEDAILAVKTEASDENLTKLLNLVYGYDSFRDGQLQAIKMILGGSSTMLVLPTGAGKSLCYQIPAMILPGITLVVSPLVSLMIDQLKHLPSIIKGGLLSSSQRPEEATETLRKLKEGIIKVLFVSPERLLNVEFLSMFRMSLSVSLVVVDEAHCVSEWSHNFRPSYMRLKASMLFSELKAECILAMTATATTMTLQAVMSSLEIPSTNLIQKSQLRDNFELSVSLSGANRMKDLLILMESPPYKEIRSIIVYCKFQYETDMISKYLRDNNINAKGYHSGLPAKDRVRIQESFCSNKIRVVVATVAFGMGLDKGDVGAVIHFSVPGSMEEYVQEIGRAGRDGRLSYCHLFYDNDTYLKLRSLAHSDGVDEYAVGKFLTHVFSTETKQHEKICSLVIESASQKFDMKEEVMQTILTHLELGEVQYLRMLPQLNICCTLNFHKSSPNTLAARSAIVAAILKKSHVKQGLHVFDIPAVASSICVATTDVLAEIQALKMKGEVTYELKDSAFCYTILKSPKEICSLSSHLTKWLTEIESCKVRKLDIMSSAAVAAISVSNTSELSSGAKQTRSLQSRIFDYFNGDEKCDSPSKATQNCAFLRADIKVFLQSNRQAKFTPRAIARIMHGVGSPAFPNSVWSKTHFWGRYMNVDFRVIMEAAQTELFNFVDRNAALAT
What is the function of this protein?
3'-5' DNA helicase that may play a role in the repair of DNA.
What are the official names of this protein?
ATP-dependent DNA helicase Q-like 5, RecQ-like protein 5, AtRecQ5, AtRecQl5.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: THII_STAAN
Sequence: MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTIEAMSAAAIKFAQQFEENSTFKIDVKRADKNFPMDTYELQRELGGTVLKQIENVSVNVKRADHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGALAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFEKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB18_RAT
Sequence: MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKLSPREESHGGGACGGYCSVL
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity).  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity).  Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity).  Also required for maintaining endoplasmic reticulum structure (By similarity).  Plays a role in apical endocytosis/recycling (By similarity).  Plays a key role in eye and brain development and neurodegeneration (By similarity).
What are the official names of this protein?
Ras-related protein Rab-18.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Apical cell membrane. Lipid droplet.
Protein: COXX_ACICJ
Sequence: MSDTILRTSATAVPDTALLDQSLLGATAGDWLALLKPRVLYLVVYTGAAGLLVAPGGINPILGFTAILCIAMAAGAAGAINMWYDRDIDAVMRRTAGRPIPTGRISPDGALAYGVALSALSVLLMWLATNLLAAGLLAASIGFYVFIYTMWLKRRTPQNIVIGGAAGAFPPVIGWAAATGHVGLLPVLLFAIIFFWTPPHFWALSLFASADYQKAGVPMLPVVAGQKATRLAVMRYTLWLVPLSLLPYVLHLAGPVYGASAMVLGLAFVWYSWRVLRDRQDGNGVSLTRDAPAKAAFKFSILYLFLIFGALVLDHLV
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CMS1_MOUSE
Sequence: MADDLGDEWWENQPAAASSPEQSGGEEGGDTEMTQQDTAPVPEKTQQPTECFLTQTKEPKAEDSRKTRKWKKKKISDILAKSEPKPGTPEDLQKLIRDHYSSSRSVIELEELHLPDSCFLKANDLTHSLSSYLKEICPKWVKLRKTHNEKKSVLMLILCSSAVRALELIRSLTAFKGDAKVMKLFAKHIKVQEQVKLLEKRVIHLGVGTPGRIKELVKQDGLHLNPLKFLVFDWNWRDQKLRRMMDIPEIRKEVFELLDMGVFSLCKSDSLKLGLF
What are the official names of this protein?
Protein CMSS1, Cms1 ribosomal small subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the CMS1 family.
Protein: SFSA_YERPN
Sequence: MLQFTPPLQPATLILRYKRFLADIVTPAGEALTIHCANTGAMTGCATPGDTIWYSTSDNPKRKYPQSWELTQTQTGDWICVNTMRANELVNLAIEKNQIAELSGYNFVRKEVKYGEENSRIDLLLQAEDRRDCYIEVKSVTLLQQQCGYFPDAVTLRGQKHLRELQNRVVNGHRAVLFFAVLHTGIKQVAPARHIDRRYAELLVQAQQAGVEVICYGFQLSPDGIELNTRLPLLLDEMLSSENAE
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: XERD_SHEON
Sequence: MAKTYQCDPLIDAFLDDLWSSKGLSDNTLSAYRTDLRHFDRYLQSQGLRLRDVGQADVRAYLAYRVEQQFARTSSARLLSSLRRFYNYLLQTKQISGDPMAQIESPKLSRHLPDSLSESQVDRLLAEPNVDDPVECRDKAMLELLYATGLRVSELVGLTMEQMSLRQGLVRIIGKGGKERLVPMGEMAITEVEHYLTSARHELLGHIQSDVVFPSKRSQMMTRQTFWHRIKLYASRAGIETELSPHTLRHAFATHLLNHGADLRVVQLLLGHSDLSTTQIYTHVARARLQELHQQHHPRG
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNX4_HUMAN
Sequence: MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM
What is the function of this protein?
Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622).  Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011).  Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622).
What are the official names of this protein?
Sorting nexin-4.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC).
Protein: RS16_ALCBS
Sequence: MVVIRLARGGSKKRPFYSIVVADSRYARDGRFIEQLGFYNPIARGGEIPLKLNLESLDAWVAKGAQLSDRVKTLAKQARKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: VMAT1_RAT
Sequence: MLQVVLGAPQRLLKEGRQSRKLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFKDSNSSLHRGPSVSSQQALTSPAFSTIFSFFDNTTTTVEEHVPFRVTWTNGTIPPPVTEASSVPKNNCLQGIEFLEEENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQLCILWPSKVSPESAMGTSLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVQVIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEKRAILSQECPTETQMYTFQKPTKAFPLGENSDDPSSGE
What is the function of this protein?
Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles.  Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis.  Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:1505023, PubMed:8125935).  Regulates the transvesicular monoaminergic gradient that determines the quantal size.  Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (By similarity).
What are the official names of this protein?
Chromaffin granule amine transporter, Solute carrier family 18 member 1, Vesicular amine transporter 1, VAT1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Vesicular transporter family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
Protein: MPH3_YEAS7
Sequence: MKNLSFLINRRKENTSDSNVYPGKAKSHEPSWIEMDDQTKKDGLDIVHVEFSPDTRAPSDSNKVITEIFDATEDAKEADESERGMPLATALNTYPKAAAWSLLVSTTLIMEGYDTAILGAFYALPIFQRKFGSQNDKTGEWEISASWQIGLTLCYMAGEIVGLQLTGPSVDLVGNRYTLIIALFFLAAFTFILYFCNSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMKNSQKKYADSELGYKLPFALQWILPVPLALGIFFAPESPWWLVKKGRFDEARRSLRRTLSGKGPEKEILVTLEVDKIKVTIDKEKRLTSKEGSYSDCFEDKINRRRTRITCLCWAGQATCGSILIGYSTYFYEKAGVSTEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLYAFGLAFQTIVFFIIGGLGCSSTHGSKMGSGSLLMAVAFFYNLGIAPVVFCLVSEMPSSRLRTKTIILARNTYNVVSIICSVLILYQLNSKKWNWGAKSGFFWGVLCFCTLIWAVVDLPETAGKTFVEINELFKLGVSARKFKSTKVDPFVVKNTPKYVSHNDPKGDIEASIAEE
What is the function of this protein?
High-affinity uptake of maltose and maltotriose.  Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose (By similarity).
What are the official names of this protein?
Alpha-glucosides permease MPH3, Maltose transport protein 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYDP_SHEDO
Sequence: MSCSSALEKFINSYLNSYQNALSELPRYYPMGVASPCIAQTFDEQSEDAVFWQPVKREPAGDFDNVASALAITLHQDINHFYASFFSAPLQFNSPWGEGELLLAWSLEDFEYLQQNIIGHLLMKQKLKQAPTWFIGVLSDGDTMITVENDTGAVWIEVPGEVPKQQLAPSIAEFITQLSPRITPAIKPVQEVDPQWQHPGIWQRMKLMWRDLTHRSRK
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: ACCA_FRATH
Sequence: MNYLDFESKIKEIEDKITSLSHVFEDEKTEAEIKKLSKKRLELMESTYSKLTDWQVVQLSRHPDRPYFKDLLPLIFTDFQELHGDRTFGDDLAVIGGLAKLNNKPVMVIGQEKGRDTKSKIKHNFGMMHPEGYRKALRLMKLAEKFNMPVVTFIDTPGAYPGIKAEERGQSEAIARNLLEMSALKVPVVCIVIGEGCSGGALGIGVGDRLLMLQYSYFATISPEGCASILHKTAEKASEVTQMMNITSGRLKELKIVDEVIPEPLGGAHRDYETTATNIRKAVAAELKILSEMTVEQRNSRRYDKLMSFGRFKEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPD_DICDI
Sequence: MSVHPRNQGKDDCCEKTHLDSQYSPGYYWLGNNTLKVPLVLHKENRQRLVSQILSKHKDQVKENSFILLESGKSTMQYDTDHEPLFKQERYFFWTFGSDIPDCFGIVGLDEQATSILCIPKLPAEYATWMGEIRSKEYYKSIFLVDQVLYVDEMMDYLKSKNASTIYTILGTNTDSGSTFVEPQYPGLRETFNVNNTLLFPEIAECRVIKSPKEVEVIRYCVDASVSAHKHVMRKVKVGLKEYQCESEFLHHVYNEWGCRNVGYTCICAANKNSAVLHYGHAGEPNSATISENGFCLFDMGAEYHSYTADITCSFPATGKFSPEQRVVYQAVLDASVAVMEAMRPGVSWVDMHKLAERCILAALLKAGILVGDLQDLIANKIGSVFFPHGLGHFLGLDTHDVGGYLGDCQPKVHSLRTTRTLKAGMVITSEPGCYFINHLLTQALSNPETAKFFNLTELDKYRNIGGVRIEDDILVTETGCDNLSKNLPRTIDEIEAFMLK
What is the function of this protein?
Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Peptidase D, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.
Protein: FADB_ECOLI
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIGLVDGVVKAEKLVEGAKAVLRQAINGDLDWKAKRQPKLEPLKLSKIEATMSFTIAKGMVAQTAGKHYPAPITAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDVETPKQAAVLGAGIMGGGIAYQSAWKGVPVVMKDINDKSLTLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDIVVEAVVENPKVKKAVLAETEQKVRQDTVLASNTSTIPISELANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKDYRDAIDALFDANRFGQKNGLGFWRYKEDSKGKPKKEEDAAVEDLLAEVSQPKRDFSEEEIIARMMIPMVNEVVRCLEEGIIATPAEADMALVYGLGFPPFHGGAFRWLDTLGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGDLKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: SSUD_PSEE4
Sequence: MSLNIFWFLPTHGDGKYLGTTEGARAVDHGYLSQIAQAADRLGFGGVLIPTGRSCEDSWLVAASLIPVTERLKFLVALRPGIISPTVAARQAATLDRLSNGRALFNLVTGGDPDELAGDGLHLNHQERYEASVEFTRIWRKVLEGEVVDYDGKHLQVKGAKLLYPPIQQPRPPLYFGGSSDAAQDLAAEQVELYLTWGEPPAAVAEKIAQVREKAAAQGREVRFGIRLHVIVRETNEEAWAAADKLISHLDDDTIARAQASLARFDSVGQQRMAALHGGKRDKLEVAPNLWAGVGLVRGGAGTALVGDGPTVAARVKEYADLGIDTFIFSGYPHLEESYRVAELLFPHLDVQRPEQPKSGGYVSPFGEMVANDILPKSVSQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: YHBP_SHIDS
Sequence: METLITISRWLAKQHVVTWCVQQEGELWCANAFYLFDAQKVAFYILTEEKTRHAQMSGPQAAVAGTVNGQPKTVALIRGVQFKGEIRRLEGEESDLARKAYNRRFPVARMLSAPVWEIRLDEIKFTDNTLGFGKKMIWLRGSGTEQA
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: CHEF_CHAGB
Sequence: MMEHTAHDRELPIRPGWDSVVNIAESRSCFSRFQSCFARPQKLVVVIGLCLLLCSPPPGAQGLPTAADWKTLSNELSGRLHQGVPLARPCFSTYNGQPAAADEEECAAIRHRYLDAEFRANQYAGFYFAQGDGCISNTTNQCQLDPENLGASPGSGLPCNQGLVSPWYVDVRSASDVQSAFRFARRTGTPISIKASGHDYVNRHTLPGSLGLWTRNLRNMTYHATFRPAGVSGAEPVQAITFGSGVNSNEAQAFAGRNNVTLVGPSSATIAIVGGWTLFGGHSVLSPTLGLGVDRVLQIELVTPDGALRICNRQLHADLFWALRGAGAGTYGVVLSMTVRVEPATPVTLALLSFTPTLENQAPFLDLLINNTPAWSAGGWGGPMTSSSLALVSLEQDEAAAAQSMRAAADYVRGENGTVTIEQFPTYSEFYARYIAVSESYVGIGALPTLRVLPKRLHDQPQGRAELLAFLSQRARNNQTPYLFMTPPARYSTPRDSTSMHPAWRNSYWLAGFQSSYAWNASVAERREAAREDQTSARDLTALAPEGAAYPNEASPWHRDWRREFWGDDNYARLEAVKARYDPAGLLRCWHCVGFDDAWVHADPAFECMGAFDGLV
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of chaetoglobosin A which has a unique inhibitory activity against actin polymerization in mammalian cells (PubMed:23611317, PubMed:33622536).  Chaetoglobosin A and its intermediates are involved in the morphological differentiation of C. globosum (PubMed:33622536).  The first step of the pathway is the synthesis of prochaetoglobosin I via condensation of one acetyl-CoA, 8 malonyl-CoA, and a L-tryptophan molecule by the PKS-NRPS hybrid synthetase cheA, followed by reduction of backbone double bond to install desired geometry by the enoyl reductase cheB (PubMed:23611317).  Further multiple oxidation steps performed by the cytochrome P450 monooxygenases cheE and cheG, as well as by the FAD-linked oxidoreductase cheF, lead to the formation of chaetoglobosin A (PubMed:23611317).  Depending on the order of action of these reductases, distinct intermediates can be identified (PubMed:23611317).  Within the pathway, the cytochrome P450 monooxygenase cheE catalyzes a stereospecific epoxidation on prochaetoglobosin I, cytoglobosin D, and chaetoglobosin J intermediates (PubMed:23611317).  The FAD-linked oxidoreductase cheF performs dehydrogenation of the C-20 hydroxyl groups in the 20-dihyrochaetoglobosin A and cytoglobosin D intermediates (PubMed:23611317).  Finally, the cytochrome P450 monooxygenase cheG can catalyze the stereospecific dihydroxylation of prochaetoglobosin I and prochaetoglobosin IV at C-19 and C-20, respectively (PubMed:23611317).  The Diels-Alderase cheD may play a role in the post-PKS-NRPS biosynthetic steps catalyzing Diels-Alder cyclization (Probable).
What are the official names of this protein?
FAD-linked oxidoreductase cheF, Chaetoglobosin A biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: G6PI_NITEU
Sequence: MSTLTRSPAWLALSAHQTEIANRPLRTLFDEDPQRFDKFSLQFKDLLLDYSKQPVDATTIRLLLALAEQQKLVDWLGRMANGEKINFTESRAALHIALRANSPVFMDGVDVTQEVRRVLRQIEQFVQKIHNQSHRGYSGLPITDVVNIGIGGSDLGPVMVTEALKPYHLPQLRTHFVSNLDGAHLSDTLQHINPATTLFVIASKTFTTQETLANAHSARKWFLAGGGSKQDIAAHFVAVSTNREAVSQFGIDPDNMFEFWDWVGGRYSLWSAIGLPIALAVGMEHFHSLLAGAQAMDDHFLTAPFEQNLPVILGLIGIWQINFFHITSQAILPYDQSMHRFPAYLQQLEMESNGKRVTRNGEAVDYSTGIIIWGEPGTNGQHAFYQLLHQGTQKFTADFLAPCRCHHPLSEHHPMLLANFFAQTEALMRGKTEQEVRSELANQNLSADLVEHLLPHRVFPGNHATTSILFKKLDPATLGMLIALYEHKVFVQSVIWEINPFDQWGVELGKQLAGKILAELALDKPVTGHDASTNGLINFYRAQQ
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_BRASB
Sequence: MVEKVPMTSGGYAALENELKQRQSVDRPRIIEHIAEARSHGDLSENAEYHAAKEEQSHNEGRIAELEDKLARADVIDVTKLSGETIKFGATVTLIDEDTEKKTVWQIVGEVEADAKKGKISITSPLARALIGKKMGTTVEVMAPGGAKSYEIAKVEWR
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.