PharMolix/UniProtQA huggingface dataset:
Protein: HYPA_DESOH
Sequence: MHEMGIAMQIVEIAGGAIPSGIENPSVAKVNIRVGKLTAVVPTSLTFCFNIATQDTPLAGAELVIEEVPVVARCKQCGHEWIITGPDFSCETCRAGEVDILSGRELDIVSIELKE
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: SOLI_RALSL
Sequence: MRTFVHGGGRLPEGIDAALAHYRHQVFVGRLGWQLPMADGTFERDQYDRDDTVYVVARDEGGTICGCARLLPTTRPYLLKDVFASLLMHGMPPPESPEVWELSRFAARSGAPCPRSGRADWAVRPMLASVVQCAAQRGARRLIGATFVSMVRLFRRIGVRAHRAGPVRCIGGRPVVACWIDIDASTCAALGIPSASAAPGPVLQ
What is the function of this protein?
Required for the synthesis of acyl-HSL autoinducers that bind to SolR.
What are the official names of this protein?
Acyl-homoserine-lactone synthase, Autoinducer synthesis protein SolI.
What is the protein family that this protein belongs to?
Belongs to the autoinducer synthase family.
Protein: PRTG_MOUSE
Sequence: MAPPVRPGMLPLLLLLLLPPLGSVPGVWSFSELFFMKEPQDATVTRKDPVVLDCQAHGEGPIKVTWLKNGAKLSENKRIQVLSNGSLYISEVEGRRGEQSDEGFYQCLAVNKYGAILSQKAHLTLSTISAFEVHPVSTEVHEGGVARFSCKISSTPPAVITWEFNRTALPTTMDRVTALPSGVLQIYDVGPEDAGNYRCVAATIAHKRKSMEASLTIVAANETRSFYMPTIIASPQNVTASLHQTVVLECMATGYPRPIISWSRLDHKSIDVFNTRVLGNGNLIISDVKLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRRIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSVLSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVLGNDTTHYIIDDLEPDSNYTFYIVAYMPLGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILVSWLPIPAKYRRGQVVLYRLSFRLSTENAIQVVELPGTVHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWLQDTEDPAAIRGYKLFYKEEGQQEHGPIFLDTGDLLYTLSGLDPRRKYHVRLLAYNNMEEGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTTAQVINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPTGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKDASESNQRPKRLDSSNAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSASKTAQSGTQPLSQASASVAAGSDMGKNLERATETAESLVPMMPSSFIDAKGGTDLIINSYGPIIKNNTKKKWLFFQDTKKIKVEQTQRRFTQAVCFYQPGTTVLISDEDSPGSPGQTASFPRPFGATALDTEHSANSEGSHETGDSGRFSHESNDEIHLSSVISSTPPTSNPLAGGDSDGDAAPKKHGDPAQPLPAEQTSAPQTSAGLRYAAEGFPV
What is the function of this protein?
May play a role in anteroposterior axis elongation.
What are the official names of this protein?
Protogenin, Protein Shen-Dan.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. DCC family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NUON_SALRD
Sequence: MDLSTAFPTLVTDLPAAFSMSVVGGVGLAMIVLDAFRNDHPAIPWLGVAALGVSAVWEITHLGAPPSTVFFETLRTGGFVAFINLIILLTGLATILLSVPYLNQLRYDYGEVYALIMFCTVGMIMLGSANNMVSIFLGLETMSVCLYVLTGFIREDEGAVESALKYFLLGAFSTGFFLYGIALMYGATGTMALPAMAAAELGTLSTRLLFWGGFALFLVGFFFKVSAAPFHMWTPDVYQGAPTPLTGYMSTATKAAAFAALILVLVHAVPGGEWQLSVAAVAVLTMVIGNVMALAQTNVKRLLAYSSIAHAGYLLVGLSAGTSAGYAGALFYLLVYAVMNIGAFGVMSMLEWDGKEGREQTLSSLAGIANDRPVLGSTMGVFMLSLIGFPPLGGFIGKYLVFAPAVDAGLTWLVVIGVLMSALSAYYYLRVVYVFWMQSADEVAATDPVRAAAFPRATVAATGTLVVCAVALVVLGVFFGGVLETTLGFFETTAMATAP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PLDZ_DICDI
Sequence: MMMKLLFLIALFGCVVNSIRINNDNGLSFQSNCLGGSIQIAESIPLALNLQSNLSTHDAWMELITNAKKSIDMGIFYMTLTDGGQLDPVYGGQLGLDIYKALVDANSRGVSIRIVQNQPSSSMPDTDTQNLAKLGVQVRSINWPSLVGAGILHTKVIVVDQVSAYLGSANLDWRSLAQVKELGVLFQNCPSMVSDTEIAFQQYWDAAVVTELPSDWGVQYQAAYNQTNMASLLLNGNEKFEMFLAVSPPQFVSTDRTGDIDALVSAMNGATKTICISVMDYIPASLYNSPNTFWPVMDNALRAAAYNRGVQVRMLISHWNHTNYAIPQWLHSLDQVNNIDVRWFVVPDFPNEPQVPFTRVNHAKYMVTDEQSYVGTSNWSEDYYTNTGGLSYNIYNDEFTSQLQSIFDRDWNSPYSFPVTTY
What is the function of this protein?
Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own).
What are the official names of this protein?
Phospholipase D Z, Phosphatase D3, PLD 3.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family.
Protein: TRUA_NOCFA
Sequence: MGWARQPGLRTVQGVLEDALGKVLREPIQLTVAGRTDAGVHAEGQVAHFDTAAEFDGPQLVHRLARFLPKDVRVKRADVVPPDFDARFSAIRRHYVYRLTTAPYGAEPLAARSVVPCKSAVDVDAMRRASGLLLGLHDFAAFCRRREGATTVRELQRFDWERQGDLLLAHVSADAFCWSMVRSLVGAVLAVGEGRRSPEWVAGLLRETQRSSSVTVAPAHGLSLVAVDYPADDELAARNVQTREMRSAPAVEGCCGE
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GATY_SALTI
Sequence: MFIISSKNMLQKAQHAGYAVPAFNIHNLETLQVVVETAAEMRSPLIVAGTPGTFSYAGMGNIVAIAGDLAREYNLPLAIHLDHHESLADIESKVMAGIRSVMIDGSHFPFEENVALVKSVVDFCHRYDTSVEAELGRLGGIEDDLVVDSKDALYTNPQQAREFVARTGIDSLAVAIGTAHGMYAAEPKLDFERLAEIRALVDIPLVLHGASGLPESDIRQAISLGVCKVNVATELKIAFSDALKEYFLQNPKANDPRHYMQPAKQAMKEVVRKVIHVCGCEGQL
What is the function of this protein?
Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP).  Requires GatZ subunit for full activity and stability.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatY, TBPA, TagBP aldolase, D-tagatose-bisphosphate aldolase class II, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily.
Protein: SLMA_HAEDU
Sequence: MTEPLIKMPKKSVKERQQQVLEVLIGLLNSEQGMQRVTTERLAKAVGVSEGALYRYFPSKSKMFEALIERIEQTLTSYINASKRKENSTALAVKAILYTVIEFARKNPGVTRILTGHALMFENSELKLRVAKFFDGLELQFVNILQMRKLREGKAFQDERALAGYLVTFCEGQFLRLVRSNFSSNPHQHFEKQWSLIKPLFE
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RFTN1_HUMAN
Sequence: MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVGVIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARGDHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQPSSPSGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGKMEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKSKGKLSARDKQQAEENEKNLEDQSSKAGDMGNCVSGQQQEGGVSEEMKGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGPASHSRALVGICTGHSNPGEDARDGDAEEVRELGTVEEN
What is the function of this protein?
Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579).  Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579).  Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity).  May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216).  May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).
What are the official names of this protein?
Raftlin, Cell migration-inducing gene 2 protein, Raft-linking protein.
What is the protein family that this protein belongs to?
Belongs to the raftlin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cytoplasm. Membrane raft. Endosome. Early endosome. Note=Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579). Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195).
Protein: SEC31_USTMA
Sequence: MKAYINRTATFAWSPATYESDSPLIATGTVAGALDESFSNESLLELWKPFYAASADANIDADAKPLASISTSARFNRLAWGYANPSRPKGLLAAGLENGELGIWDADKVLAAAAESDAQVIKNTTHTGPVRGLDFNPLQPNLLSSGAVAGEIFIWDLNSPAKPYSPGARSSKLDEITSLAWNCQVPHVLATSSSSGYTVVWDLRGKREVVALQYGGGAGTAVGSLGINAGSALAAGGRRGMSAVAWHPDTPTRLVTASEDDSSPVIMLWDLRNSRAPEKIMTGHDKGILSLSWCKQDADLLLSCGKDNRSICWNPQTCDIVGELPSSSNWSFEVQWSPRNPGMLATASFDGKIGVHSLQSTNAPEPDAPATQQLNEDSDFFNQATAPQTTSKGLSLKQPPKWLRRPVSAVFGFGGQLVSSGGPSSKPFTPTVHLRDFVSEPSIVERATKLQHALDGQSLAEFCAQRSQDPSTRPDDIANWKALQTLFRADSRDELVALLGFSKEDIAQKVSQSIAAFKTNGTAAVEPEVTPVTNPIDEPELTKPVTSADDGADAVEAANEIVEPAAIATEPAPEVEANDIDEPGLFGDDAAGAANNDASDFFNQISAGQTPAVRSALPSHLLSESQPHIHSSAATIGSPAPSSVASESIRPSTFKIYPSEESEADKLITRALVLGEFESAVSLCINSDRFADAFLLAVRGGEELLAKTQKAYFEKRTAQLPYLRLFQSIVSDDLTDVVQNADLGEWQEIFVVLCTFSKQDEFSNLTEQLGQRLEFQYSLARNSDITQAKEHRKNAVLCYLAAGKLEKVAGMWIDEMKEEELALRSNTKNADESHKGTLYSARAEALQTFMEKITVFQSAVGYVDVDLQQPTQDSIVAETGARSYKLAPLYDRIHEYVELLADQGLISPALRFANQTPADYRPHGPADQSATATALKQRLLKAEIARPKTDTAASSSTNNVVAAASASASSYAAAPASNGYAPYDPYGQSTSSSVPTVPSVPAVPAVNTYQDPYAAAAPSPSVAAPQPPTQSRYAPAVPAPVPTAMQPEPVQTNAYGAYGAQSYQSAYQPAQPMIPAAPAFGASSYGQQQHQQQLPPPPPLKRDQSGWNDVPEGLAAPKRTPSAMSQHKSANAITSPFPNAPAQAPSPYGGAPGAPPTGPPRGATPSRGMMSPPPQGPPSGPGLAQQRVGPPGVRPPPMGPAQGQPRPGQQQPGPPSQAAPSAGPYARPPAGPGAPSANGMQQQQQPGAPPVGPGAGALRPPGQALPGAPGLAGPPGVPQRSATPGGGAGAPSRSATPGARGASQMKYPPGDRSHIPENQRPIQHALQREVARLKATAPPAQKRMIDDTERRINLLLDHLNCGTIDAKTVGGLMQIVAAIEARNKQAALNIHLQLVTSSSGDVAAGLVGVKMIISRL
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC31.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC31 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DEF34_ARATH
Sequence: MASNKVSFFLVLCLCVLSTAEFGEAQILTGIKCPDPNGHDKEDKCNIYCLNQNYMGGSCQGYKNHYMCECYVG
What are the official names of this protein?
Defensin-like protein 34.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: VIRD4_BARHE
Sequence: MKYTKTQLALISMPIASGALTIFLVPHMLSFVINDLKTNQIYWYVRSEPLLTLMLVAAVSLFYTLSQKLHLRKAITFVSTAFFCITALYYIGSEIKRLNPYVGQQGITWGYALKFMDPMVVFGVILGFVLLAIQVIITSPRTSNVKRAKKGIFGDAAWMNLKEAARIFPSNGQIVIGERYRVDQDNVRNIPFAPGNKTTWGKGGTAPLLTFNLDFGSTHMIFFAGSGGYKTTSTVVPTCLTYTGPIVCLDPSTEIAPMVKFARKKMGNRNVIILDPNSLLTKNFNVLDWLLDENIPRTRREANIVSFSKLLLSEKKSENSSAEYFSTQAHNLLTALLAHVIFSDKYEDSERNLKTLRAILSQSETAVVNQLRMIQETTPSPFIREMVGIFTEMADQTFSGVYTTASKDTQWLSLSNYADLVCGNDFASSDIANGKTDVFLNLPASILNSYPAIGRVIIGAFLNAMVTADGNYKKRVLFVLDEVDLLGYMNILEEARDRGRKYGTSLMLFYQSSGQLVNHFGEAGARSWFESCSFVSYAAIKDLQTAKDISERCGQMTIEVTGTSKSRGLSLTKGSQNINYQQRALILPHEIIQEMRQDEQIILMQGHPPLRCGRAIYFRRKEMLAATEKNRFAPQAKKS
What is the function of this protein?
The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function.  VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a pro-inflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interfers with a potent VirB-independent mitogenic activity.  These changes of HEC require the T4S coupling protein VirD4 and at least one of the effector proteins BepA-G.
What are the official names of this protein?
Type IV secretion system-coupling protein VirD4.
What is the protein family that this protein belongs to?
Belongs to the VirD4/TraG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLPX_CITBB
Sequence: MSRRDDRSDTLICSFCGKSQEEVKKLIAGPTVYICDECIELCNDIIAEESKLEDATATDVRKLPKPQEIKEVLDEYVIGQSRAKKVLAVAVYNHYKRVEAAVKPGDVEMQKSNILLLGPTGSGKTLLAQTLARILKVPFAMADATNLTEAGYVGEDVENIILTLLQASDYDVEKAQKGIIYIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTTNILFICGGAFPGLDSIIQQRIGVKTLGFGADVKKKVEKKAGELLAGVTPEDLLKFGFIPEFVGRLPMLASLSELDEEAMVQILKEPKNALIKQYQKLFDMEHVKLKFTDGSLVAIAREALKRKTGARGLRSILENAMLDIMYEIPSQSMVKEVVINEEVIYSKEKPIIVYENVAESA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: MATK_LIRMU
Sequence: MEELQGYLEKDGSRQQHFLYPLLFQEYIYALAHNHGLNGSIFYEPVEVFGYDNKSSLVLVKRLITRIYQQNFLISLVNDSNQNRFVGYNHNNFFFSHFHSQMISESFAIIVEIPFSLRLVSYFEEKEIPKYHNLRSIHSIFTFLEDKLSHLNYVSDILIPHPIHMEILVQILQCWIQDVPFLHLLRFFLHEYHNLNSLLITQKKSIYVFSKENKRLFRFLYNSYVFEWEFLFVFIRKQSSYLRLTSSGTFLGRTHFYEKIEHLQIKHFVVVCRNYFHRTLWFCKDPFMHYVRYQGKAILASKGTHLLMKKWKYHFFNFWQYYFHVWTQPYRIHINQLSNYSFYFLGYLSSLLLNFSAVRNQMLENSFLIDTITKKFDTXVPVIFLIGSLAKAKFCTVSGHPISEPIWTDLSDSDILDRFGRICRNLSHYHSGSSKKQGLYRIKYILRLSCARTLARKHKSTVRTFLRRLGSGLLEEFFTEEEQVLSLIFPKTTPFILHGSHRERIWYLDIIRINDLVNHS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FTSK_CAUVC
Sequence: MARAARRSTTELLWDAIRYGWAQPWTARFRGGIVTVVGAVLLLAIATYNATDPSFNAVTGEPASNALGGLGAAISDILMQSLGLSAWGIALLMLVFGVTRVAQADPDADRKDLRQRALVGALGLLALSAVLAAPPPPAIWQLEKGLGGFWGDSLLHMVAAVLSFAHIPGATIIAAILFGIAAIAALGFAIGVREVDPDAIHAAVSNALQPRARPEPEPEPAPAAKPVRARREKAEPAAPRAGRLPPLEADEDETPIAASQPAAAQRAYTPPPAVQDDEDDFEDSLDARPMAIAKPKTPVKESGREAREQQKAFDFEEDAGFQLPELAMLAKSKPRSSEVDAAALRQNARLLESVLAEFGVKGQIDQIRPGPVVTMYELVPAPGVKTARVVALADDIARSMSVISCRVAVAQGRNAIGIEMPNQRRETVYLRDLLSSADYEKASQILPMALGETIGGEPYIADLAKMPHLLIAGTTGSGKSVGVNAMILSILYKLPPEKCRFIMVDPKMLELSVYDGIPHLLAPVVTDPKKAVVALKWTVREMEDRYRRMSKIGVRNIGGYNEKANEAAAKGEHFERTVQTGFDDAGRPIYETEQIRPEPMPYLVVVIDEVADLMMVAGKDIEGAVQRLAQMARAAGIHLIMATQRPSVDVITGTIKANFPTRISFQVTSKIDARTILGEQGAEQLLGQGDMLYMAGGGRITRLHGPFVSDGEVEAVARFLRDQGIPQYLDEVTAGGDEEQEEAIEGAFSGEGGANDLYDHAVAVVTRDRKASTSYIQRRLQIGYNRAASLMERMEKEGVVGAANHAGKREILAPPTPPL
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination.  FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation.  FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: VTI1_YEAST
Sequence: MSSLLISYESDFKTTLEQAKASLAEAPSQPLSQRNTTLKHVEQQQDELFDLLDQMDVEVNNSIGDASERATYKAKLREWKKTIQSDIKRPLQSLVDSGDRDRLFGDLNASNIDDDQRQQLLSNHAILQKSGDRLKDASRIANETEGIGSQIMMDLRSQRETLENARQTLFQADSYVDKSIKTLKTMTRRLVANKFISYAIIAVLILLILLVLFSKFK
What is the function of this protein?
t-SNARE found in various SNARE complexes involved in multiple transport pathways.  The composition of the t-SNARE complexes is specific for a limited number of v-SNAREs and therefore allows only the vesicles carrying the matching v-SNARE to fuse.
What are the official names of this protein?
t-SNARE VTI1, Qb-SNARE VTI1, VPS10-interacting protein 1, Vesicle transport v-SNARE protein VTI1.
What is the protein family that this protein belongs to?
Belongs to the VTI1 family.
What are the subcellular locations of this protein?
Prevacuolar compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Note=A small portion is localized in the Golgi apparatus, the majority is localized in the PVC.
Protein: QUEA_OCEIH
Sequence: MQIEDFDFHLPEELIAQTPLKDRTSSRLCVLDKQTSEITHRSFKDITTYLQAGDCLVLNDTKVLPARLYGVKSDTGAKIEVLLLHQQEEDTWEVLVKPAKKVKVGTEIIFGNGKLKATCIDLKDHGGRIMTFSYTGIFYEILDQLGEMPLPPYIKEQLPEQDRYQTVYAKEKGSAAAPTAGLHFTDKLLEDIKAMGVNIVFVTLHVGLGTFRPVSVDSVEDHDMHSEFYSMSESAAKTLNEAKAAGRRIISVGTTSTRTLETIVRDHDGKFVATRGWTDIFIYPPYKFRAIDGLITNFHLPKSTLIMMISALAGKEAILHAYNEAVKEEYRFFSFGDAMLIL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMB_XYLFA
Sequence: MAVAMTPAAADELHTIVDLIRYGASRFSEAGLTFGHSYDNALDEATQLVLHALHLPPDLGPAYGQARLLHTEKECVLALFERRVTERVPVAYLTGDAWFAGLNFKSDARALVPRSPIAELIQAGFEPWLAGRDVRHALDLCTGSGCIAIAMGHYNPHWSVDGADISEDALSLALENKVRLLAHNVELIKSDVFAGLVGRRYQLIVSNPPYVTDAETDALPQEYGYEPELGLRAGPDGLNLVLKILRDAPAHLDEEGLLICEVGESEQQLVRLLPQVDFAWVEFKVGQMGVFAVECRELIAHHDPIAALAAER
What is the function of this protein?
Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.
What are the official names of this protein?
50S ribosomal protein L3 glutamine methyltransferase, L3 MTase, N5-glutamine methyltransferase PrmB.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
Protein: RL32_CHLPN
Sequence: MAVPRNRHSNARKNIRRSHDAKKACHAAKCSNCKHALLPHTICPSCGFYNGKAVMTVEKK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: LALBA_BOSMU
Sequence: MMSFVSLLLVGILFHATQAEQLTKCEVFRELKDLKGYGGVSLPEWVCTTFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSSDICNISCDKFLDDDLTDDIMCVKKILDKVGINYWLAHKALCSEKLDQWLCEKL
What is the function of this protein?
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme.  This enables LS to synthesize lactose, the major carbohydrate component of milk.  In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
What are the official names of this protein?
Alpha-lactalbumin, Lactose synthase B protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL29_PROM5
Sequence: MKNSESIKEFKKLNSSEINEKIDQLRKDLFDLRFKQATRQLNETHQFKIIKKQVAQLLTLSKSQSNSQKSSD
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: TRA2_DICDI
Sequence: MEVADRMMSNGVDNDRRSSPSPHRGNGDMNNGNGNGNRDSRERSPPRGNSRERSPPRGGSPNRGGSPNRGGSPNRGGSPNRGGSPSRDDKRRYGNGGNGETRNRLANTASPSNVLGVFGLAPQTEERDLKDEFSRFGKIDHVDLIMDRKTGRSKCFGFVYFENKEDAVRAKEECQDLQLHGKSIRTDFSATKKPHEPTPGKYFGNPRYDSRRSPPRFSPYGGGDRYGRGDYGGRGGGGDRYGRDDRGGDRYGRDDRGGDRYGGRDDRGGDRYGGRDERGGDRGGDRYGRDDRDRHREDSRDRYNDRGGDRYNDRFRDERPRDSYRR
What is the function of this protein?
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
What are the official names of this protein?
Transformer-2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RN220_BOVIN
Sequence: MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDTESPHLRFSDADGKEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDREASSSPEDRNDRCKKKAAALFDSQAPICPICQVLLRPSELQEHMEQELEQLAQLPASKNSLLKDAMAPGTPKSLLLSASIKREGESPTASPHSSATDDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQREGSCMAEDDAADIEHENSNRFEEYEWCGQKRIRATTLLEGGFRGSGFVMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPEFSKWASDEMPSTSNGESSKQEAMQKTCKNSDIEKITEDSAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCYTITAPGDLRRIYL
What is the function of this protein?
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity).  Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF220, RING finger protein 220, RING-type E3 ubiquitin transferase RNF220.
What are the subcellular locations of this protein?
Cytoplasm.