PharMolix/UniProtQA huggingface dataset:
Protein: RRP1_DROME
Sequence: MPRVKAVKKQAEALASEPTDPTPNANGNGVDENADSAAEELKVPAKGKPRARKATKTAVSAENSEEVEPQKAPTAAARGKKKQPKDTDENGQMEVVAKPKGRAKKATAEAEPEPKVDLPAGKATKPRAKKEPTPAPDEVTSSPPKGRAKAEKPTNAQAKGRKRKELPAEANGGAEEAAEPPKQRARKEAVPTLKEQAEPGTISKEKVQKAETAAKRARGTKRLADSEIAAALDEPEVDEVPPKAASKRAKKGKMVEPSPETVGDFQSVQEEVESPPKTAAAPKKRAKKTTNGETAVELEPKTKAKPTKQRAKKEGKEPAPGKKQKKSADKENGVVEEEAKPSTETKPAKGRKKAPVKAEDVEDIEEAAEESKPARGRKKAAAKAEEPDVDEESGSKTTKKAKKAETKTTVTLDKDAFALPADKEFNLKICSWNVAGLRAWLKKDGLQLIDLEEPDIFCLQETKCANDQLPEEVTRLPGYHPYWLCMPGGYAGVAIYSKIMPIHVEYGIGNEEFDDVGRMITAEYEKFYLINVYVPNSGRKLVNLEPRMRWEKLFQAYVKKLDALKPVVICGDMNVSHMPIDLENPKNNTKNAGFTQEERDKMTELLGLGFVDTFRHLYPDRKGAYTFWTYMANARARNVGWRLDYCLVSERFVPKVVEHEIRSQCLGSDHCPITIFFNI
What is the function of this protein?
Plays a role in the cellular response to oxidative stress by promoting DNA repair mechanisms such as base excision repair and possibly homologous recombination repair (PubMed:1713691, PubMed:16507570).  Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16507570).  Likely to initiate repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends (By similarity).  Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:16507570).  Has apurinic endonuclease and double-stranded DNA 3'-exonuclease activities and carries out single-stranded DNA renaturation in a Mg(2+)-dependent manner (PubMed:1713691, PubMed:8918793).  Activity is more efficient in purine-rich regions of dsDNA than in pyrimidine-rich regions (PubMed:8918793).
What are the official names of this protein?
Recombination repair protein 1, DNA-(apurinic or apyrimidinic site) endonuclease.
What is the protein family that this protein belongs to?
Belongs to the DNA repair enzymes AP/ExoA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PURA_STRA1
Sequence: MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDNKKFKLHLIPSGIFFKEKISVIGNGVVVNPKSLVKELAYLHGEGVTTDNLRISDRAHVILPYHIKLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDREVFAERLKINLAEKNRLFEKMYDSTPLEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDEVGDRIREIGKEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLDTVKICVAYDLDGKRIDYYPASLEQLKRCKPIYEELPGWSEDITACRSLDGLPENARNYVRRVGELVGVRISTFSVGPGREQTNILESVWSNI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_BACC4
Sequence: MKIALIAHDKKKNDMVSFAYAYKPIFEQHELFATGTTGLRIMEATGLVVTRYQSGPLGGDQEIGAMIAKNDLDMVIFFRDPLTAQPHEPDVNALLRLCDVYAIPLATNMASAEMLMHALERGDLDYRKLRK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: Y194_ARCFU
Sequence: MDSKAVLKGMLEKAYRIEAGFEKRG
What are the official names of this protein?
Uncharacterized protein AF_0194.
Protein: RL333_BACAN
Sequence: MRVNITLACTECGDRNYISKKNKRNNPERIELKKYCPRLKRVTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PEPQ_SALTI
Sequence: MESLAALYKNHIVTLQERTRDVLARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEEVEVVALPKADGIGSQLPAARGNIGYIGPVPERALQLDIAASNINPKGVIDYLHYYRAYKTDYELACMREAQKMAVSGHRAAEEAFRSGMSEFDINLAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPSEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAHLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPSKYPYLRCTRVLQPRMVLTIEPGIYFIESLLAPWREGPFSKHFNWQKIEALKPFGGIRIEDNVVIHENGVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: M2_I73A5
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: DJA7B_ORYSJ
Sequence: MALLQFGGTLAPKLGEKPQLLPRSPALTRVIYADPRFLVSKSGSGGRLKHLVSPTASLQSRTSSRLFNHAPSPRFRHRRSSRFIVRADADFYSTLGVSRNASKSEIKSAYRKLARSYHPDVNKDPGAEQKFKDISNAYEVLSDDEKRSIYDKYGEAGLKGAGMGTGDYSNPFDLFESLFEGFGGMGGMGGRAARNRPMQGDDEAYNLVLNFKEAVFGVEKEIEITRLEGCNTCDGTGAKPGTKPTTCKTCGGQGQVVSSTRTPLGIFQQVSTCNTCGGTGEFSTPCNTCGGDGRVRKTKRISLKVPAGVDSGSRLRVRSEGNAGRRGGPPGDLYVFIDVLSDPVLKRDGTNILYTCKVSYIDAILGTTVKVPTVDGMVDLKIPSGTQPGTTLVMSKKGVPLLGKSNARGDQLVRVQVEIPKRLSSDERKLIEELANLNKAQTANSRR
What is the function of this protein?
Plays pivotal roles in chloroplast development.  Is essential for the regulation of chloroplast development and differentiation.
What are the official names of this protein?
Chaperone protein dnaJ A7B, chloroplastic, Chaperone protein dnaJ A7, OsDjA7.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: 53DR_STAAR
Sequence: MTRKSIAIDMDEVLADTLGEIIDAVNFRADLGIKMEALNGQKLKHVIPEHDGLITEVLREPGFFRHLKVMPHAQEVVKKLTEHYDVYIATAAMDVPTSFSDKYEWLLEFFPFLDPQHFVFCGRKNIVKADYLIDDNPRQLEIFTGTPIMFTAVHNINDDRFERVNSWKDVEQYFLDNIEK
What is the function of this protein?
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides.
What are the official names of this protein?
Putative 5'(3')-deoxyribonucleotidase.
What is the protein family that this protein belongs to?
Belongs to the 5'(3')-deoxyribonucleotidase family.
Protein: KBAZ_ECO24
Sequence: MKHLTEMVRQHKAGKTNGIYAVCSAHPLVLEAAIRYASANQTPLLIEATSNQVDQFGGYTGMTPADFRGFVCQLAESLNFPQDALILGGDHLGPNRWQNLPAAQAMANADDLIKSYVAAGFKKIHLDCSMSCQDDPIPLTDDIVAERAARLAKVAEETCLEHFGEADLEYVIGTEVPVPGGAHETLSELAVTTPDAARATLEAHRHAFEKQGLNAIWPRIIALVVQPGVEFDHTNVIDYQPAKASALSQMVENYETLIFEAHSTDYQTPQSLRQLVIDHFAILKVGPALTFALREALFSLAAIEEELVPAKACSGLRQVLEDVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFAHLVRNLADSPIPLPLISQYLPLQYVKVRSGELQPTPRELIINHIQDILAQYHTACEGQ
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of KbaY.  When expressed alone, KbaZ does not show any aldolase activity.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. KbaZ subfamily.
Protein: EFG_SODGM
Sequence: MARITPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHNGAATMDWMAQEQERGITITSAATTCFWAGMAKQFDSHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANYLRVVEQLKTRLAANPVPIQLAIGAEEKFTGVVDLVKMKAINWSEADQGVTFTYEDIPADLTELADKWHQHLVESAAEASEELMDKYLGGEELTEEEIKHGLRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIEYLPAPTDVAAINGVLEDGETHAERHSSDEEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKDKRERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDTSAPIILERMEFPEPVISVAVEPKTKADQEKMGLALGRLAQEDPSFRVWTDEESGQTIIAGMGELHLEILVDRMRREFNVEANVGKPQVAYRETIRSIVEQEGKFVRQSGGRGQFGHVWLRIEPMEPGGKGYEFLNEIVGGVVPKEYVPAVDKGVQEQLKSGVLAGYPIVDVRVAAFDGSYHEVDSSEMAFKIAGSMAFKEGFMKAKPVLLEPIMKVEVETPEDYMGDVIGDLNRRRGMIDGMEDTTTGKTVRAQVPLSEMFGYATDLRSQTQGRASYSMEFLKYNEAPNNVAQAIIETRRAK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EI3F2_DROGR
Sequence: MSISNYKMHTKVRLQPLVLFQIISAYEHRPKLAEVAVGTLLGLRDRSNDTIEITNSYMVIHKTQQIGEMEQVKLDKQYASEMYELNQINNPQEKIVGWYNTAKSLSRSSAALHAYYARECADAQPLHLLVDLKLRGGRLNTRLYCGVPIGVPGGTKGLMFTLLPLLKMGTEIDDSVALRVMQNYALNPAKQPGRILPELMSVLEITLALEEKLDLLLRYIKDVLARKRLPDKRVGRALYEALTSVPMMDAESFRLMFNTNVRDILLSITLSTMIKTQLELSEKLSHLPNH
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit F-2, eIF3f-2, Eukaryotic translation initiation factor 3 subunit 5-2.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit F family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRD_MYCGE
Sequence: MNEQQKQAISCGKGVNVVYSGAGTGKTTIITNRFAYLVNKEKVDPSRILAITFTKKAAKEMQFRILKLIDSSLAEKTNIYTFHSFCNKFLIQTLKKRFIIDDDISYFLKEFLADSKLDINLAKQIIDNFKNTFADFEINKLDQDERLISLCEHSLLNKDEEYSTLKTQLINAFISYEKNKILNNKLDFHDLLIKTCNLLSNDNDLLNQWSEQFQHILVDEFQDTNQIQYELIKMLVTKNKNLFLVGDNNQMIYRWRGAVNGIITALKHDFNVPKSNEFFINQNYRCDQNILAVANQILLKIMAYEKQVKTEKNLLFSTLNSDKKPVYFQAESVENQANWIFNKIKALNQTEKINFKDMAILFRKNRDITTMVELIEADGTIPLPKQKSYFNQLVKLQRVLIAISTRTNLDIKRALQALKIWSNDLKELWKQSDKTNLFDFLKWSELNQKNHSSKLKATGYFNLLIKLAEDQQINLLFTELFKKLKVDQTIENLLWKKLTEFQKDKTEFSLSEFITSLALEFDSIIENSSDTINLLTVHAAKGLEFEAVFIYGMNQGDFPLFLSQNQNDEQHLIDELKLFYVAITRAKRFLFITAVLQINNNSIKPSSFLNYINKSEYLDIATINYVLEQDDDFFDSTKKTDYTKKLRKESLDIIVGDLVTSRYFGKGVVVEVRDKEVLVAFKDTRYGMKWILKNHKSLTKALY
What is the function of this protein?
Has both ATPase and helicase activities.  Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present.  Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity).
What are the official names of this protein?
Probable DNA helicase II homolog, DNA 3'-5' helicase II.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: UXAB_ECOSE
Sequence: MKTLNRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGALDKGWIIIPCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLEEELGYHDGFLDTAEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAMNDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKAKGTLPARLTFALAALIAFYRGERNGETYPVQDDAHWLERYQQLWSQHRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDAILEKGMREAVRPLC
What are the official names of this protein?
Altronate oxidoreductase, Tagaturonate dehydrogenase, Tagaturonate reductase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family. UxaB subfamily.
Protein: NRAP_MOUSE
Sequence: MNVQACSRCGYGVYPAEKISCIDQTWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAHNPKNNTFTSVYHTPLNLTLKKSVAAMGGIDGKEDGEPFKSVLHWDMKSKAGAGAASRLMNERDYWPGYAEGNTWCPGALPDPEIVRMVEARQSLGEGYTEDREQQQGKGSFPAMITPAYQRAKAANQLASQVQYKRGHDERVSTFTPVADTPELLRAKAGGQLQNDVRYTEDGGQQRGKGSFPAMITPAYQIAKRATELASDVRYHQQYHREMKGMASPVGAEGGMTKDSVDRCGQVYSEECDEPRGKGSFPAMITPAYQNAKKANELVSDIKYRQDFHKMKGAAHFHSLAAQDNLVLKRAQSVSKLVSEVEYKKGLENSKGHSINYCETPQFRNVSKISKFTSDNKYKENYQTQLRGHYDGVGMDRRMLHALKVGSLASNVAYKADYKHDVVDYNYLATATPFYQTTMRLVPLKDVNYRQNIDRMKFSSVTNTPQIVQAKINAQQLSHVNYRADYERNKLNYTLPQDAPQLLKAKANAELFSEVKYKEGWQKTKGKGFEMKLDAMSLLAAKASGELASSVKYKEEYEKMKGRALGATDSKLLHSLQVAKMSSEVEYKKGFEESKTHFNLPMDMVNLRHAKKAQALASDLDYRKKLHDYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMRGVGWLTEGSLNLEQAKKAGQLISEKNYRQRVDELKFTSVADSSQMEHAKKSQGLQNAVAYKAGNEQSVHQYTISKDEPLFLRARANAAQLSETLYKSSWEKQKAKGFELRLDSLAFLTAKAKRDLASEVKYKEDYERSRGKLIGAKSAQGDSQMSHSLQMSKLQSDLEYKKGFEDTRSQCHISLDMVHLVHARQAQHLATDVGYRTASHCFTALPTDMKVEWAKKAYGLQSDNQYRADMKWMKGTGWVATGSLHVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENVKHHYTQTADLPEVLLAKLNAMNISETRYKESWSRLRDGGYKLRLDALPFQAAKASSEVISDYKYKEAFERMKGQMLGSRSLEDDLSLAHSVHATSLQSDVNYKKGFEHAKAHFHLPLDMVTLVHAKKAQTLASDQDYRHPLPQHTVLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGVPCVVPGTLEIEGRKKASELISESKYRQHPGSFKYTAVTDTPNLLHAKYSNQITNERLYKAAGEDARHQYTMTLGLPEFIRAKTNAANLSEAKYKEAWHNLRAQGYKLTIDALPFQAARASGDIASDFLYRHEFVKERGQLIGVRNVSDDPRLLHCLRMGQLQSENQYRKEAASSQAQCHLPMDMMYLVHARKAQALASDHDYRTQCHEFTALPEDLKMAWAKKAHALQSEFRYKADLMGMKGTGWLALQSPQIESAKKAGDLISETKYRKKPDSIKFTTVVDSPDLIHAKESYMHCNERLYRLGDAASLHRYTPIPDHPDFTRARMNAMHLSDKVYRNAWEQSRAGGYDFRLDAIPFQTARVSRDIASDFRYKEAFLRDRGLQIGYRSISDDPRTTHFLRVGRLQSDNEYRKAFAKGRSQFHSRADQPGFLQAKRSQQLASDVLYRQPLPQHTSDPEQLGLKHARKAHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANRRGPGIRGASVEPEAAAALGDHQSRGVNPDASEILHIHKKKTLLM
What is the function of this protein?
May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.
What are the official names of this protein?
Nebulin-related-anchoring protein, N-RAP.
What are the subcellular locations of this protein?
Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle.
Protein: HEMA_RUMJO
Sequence: MQLGRHNSGSIKKRLEMYILSIISASLDYKSAAIDIRERFSYTSTRIREILRRIKAADGVSGAVLLCTCNRTELYISGDNIENMNPALLLCQLSGEEDHKSLMTLFSIRHDSEAIFHLMEVACGLQSMVLFEDRVITQVKNAAAISREEKTIDSTLETLFRLCITAAKKAKTEIKVKAVPTSAAERAITELSKKYCFTDKRILVIGNGEIGRLCCKKLIELGAEITITLRKYKHGEIIIPVGCNTIPYDEREEVLPLSDVVISATTSPHFTITYDMIEKLERKPEIFVDLALPRDIESSISNFTGVELYNLDRFYTDYSVLNQKEVSKIREIINHFILQFEKWKDYREEAAFTKIPDLHNDTLYGRFPLFIDLSGKKVLVVGGGEIATRRVKTLLRFGADIYLVAPHLTSELQEMLNCKLINYREGYYESQDIQNMFLVIAATNDRETNHKVYLDAKEKGIQMSIADCREECSFYFPAIFEFDGIVGGLVSQNGDNHSLVKSVAEQIRKIGQATD
What is the function of this protein?
Multifunctional enzyme that catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA), the NAD-dependent ring dehydrogenation of precorrin-2 to sirohydrochlorin and finally, the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Probable multifunctional siroheme biosynthesis protein HemA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
Protein: RECF_MICLC
Sequence: MYLSHLTVADFRSYRWADLELTPGSTVLLGANGVGKTNLVEAIGYLGAQQSHRVSSDAQLVRFGRDRARIAGRVHRGSRTVALKVEILPGRSNRVAINRGASVRAKEGLGILRTVVFAPEDLSLVTGEPGGRRRLLDQLMVQLRPALGEAAADYERVLRQRNALLKSGRGSRRWGPEEDATLAVWDEHLCAAGARLLHGRLHVLRLLARPLQEMYAALTNGSKAAAYAYESTVPLARGTHAEVPAVADLATDMRRTLEAQREEERARALTLVGPHRDELALFLGPAPARGYASHGETWSLALALRMAAYDVLVADDPDPDARPVLILDDVFAELDAARRRRLAALVHRAEQVIVTAAALEDVPEELTAHRVLIRQDAEGSEAVAAAAPVEGDIREPRREGGADG
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_NEIG2
Sequence: MRKPQRGYARQDRVKEQIMRELAELVRTGLKDPRAGFITINEVEVTRDYSHATVFYTVLNQDTREITEEVLEHARGHLRSELSKRIKLFKIPELHFKYDESLERGMSLSALIDQVAAEKPVED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERVA_TABDI
Sequence: AVIPLKNQGKCGSCWAFSTVTTVESINQIRTGNLISLSEQQLVDCSKKNHGCKGGYFDRAYQYIIANGGIDTEANYPYKAFQGPCRAAKKVVRIDGCKGVPQCNENALKNAVASQPSVVAIDASSKQFQHYKSGIFTGPCGTKLNHGVVIVGYGKDYWIVRNSWGRHWGEQGYTRMKRVGGCGL
What is the function of this protein?
Cysteine proteinase.
What are the official names of this protein?
Ervatamin-A, ERV-A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: Y80K_PARPR
Sequence: MIAFQAENLIENGTKRLFNFIFTSHLQMMDENGNMTKTEISTHKLEQCNISHFNEFDEASTYNVVIYYNHQKLLKDQLNDYYCLPLNYSLQIQGTQKSNIFQYGKISVTICSSDDCYSTDEIQQFQRLGYFNNSFKINTLMLNRVPNLNIPNNYISYIYSDYYIQAKIGQEIKTDVYLEQQQLSIEKSVIPGIKVLEQDHVFSIMENKLQASSVFTSNITRVASFFIRLSQSETHYYKEYYRFDELFSYVGGITQFLATILGYFILRYNQTGLQIKLANSLYQFDMPEKQKGQMVFSFQLLVNKIFESLKSIEDAVQKFKNSAHRIINLTRLAGGLKFINQQSYQNDDIDDEIVNHLATQQVPQTDKLKVEKCADHCHESNQTFYLQQDKKKFLSLIVQLILESRKKLSFGVHFLAKQVSGSFKKNTAVNYQSQLFEKSRKMILRDMDILVIMNKLQEIEKIKHVIFNKTQRKVFNYLQKPVVCVKKKINQDKYDQSLIHGDLKNKRDDTLRLTMSSKSLLGIRQKYNTEKKFNKLYEAYEELALAEDPNETEKIMNQRLLKLVEPTIQYSFNSLVEIEKLSRQLRYNKKKRVETQVLKPHNFKLGSSNEVEEEIENNFDIESITLNGQKKDNLYKKSQPSLPENKIKNLTTLQSSTRQLKDVQLNQIQSKQDFLDVEIISS
What are the official names of this protein?
Uncharacterized 80 kDa protein.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MNMA_HAEDU
Sequence: MALNSITYQKCFHTSAQQYADNKNKKVIIGMSGGVDSSVSAFILQQQGYQVEGLFMKNWEEDDDTDYCTAAADLADAQNVADRLGIKLHKINFAAEYWDNVFEHFLAEYQAGRTPNPDILCNKEIKFKAFLEYAAEDLGADYIATGHYVRRSADNENAQLLRGLDANKDQSYFLYTLSNQQVAKSLFPVGEIEKPMVRQIATDLGLVTAKKKDSTGICFIGERKFKEFLARFLPAQPGDISTVEGEIVGRHDGLMYYTLGQRKGLGIGGVKGLSEDPFYVVEKDLVNNVLIVAQGHDNSALLSTGLIANQLHWVDRKTIGDTLRCTVKTRYRQTDIACLVEPIDAENIRVIFDEPQIAVTPGQSAVFYQGEVCLGGGVIEAQLK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y6031_MYCS2
Sequence: MAGRVEGKVAFITGAARGQGRSHAVRLAEEGADIIAVDVCRRISSNEDIPASTPEDLAETVELVKGLNRRIVAEEVDVRDYDALKAVVDSGVEQLGGLDIVVANAGIGNGGATLDKTSEADWDDMIGVNLSGVWKTVKAAVPHLISGGNGGSIILTSSVGGLKAYPHTGHYIAAKHGVVGLMRTFAVELGQHSIRVNSVHPTNVNTPLFMNEGTMKLFRPDLENPGPDDMAVVAQMMHVLPVGWVEPRDISNAVLFLASDEARYVTGLPMTVDAGSMLK
What are the official names of this protein?
Putative short-chain type dehydrogenase/reductase MSMEG_6031/MSMEI_5872.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: EX7S_BART1
Sequence: MKKEIQEGDITTLSFEQALKQLEVIVENLERGDVPLEQSIDIYERGEALKKHCEKLLKVAEAKVEKIQLSQEGSPEGVEPLDAQ
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_BACAH
Sequence: MTKWKRANPNGTRDYLFEECTLIEEVEQKLRRTFLERGYEEIRTPTIEFYDVFAFQSRPIDEEKMYKFFDEKGRIIVLRPDMTIPLARVVGTQRCDTPLKVTYSGNVFRANESLAGKYNEIVQSGIEVIGIDNVRAEIECVISVIQSLQKLKVQSFTIEIGQVQLYKCIVKKLSIHEEEEKVLRTYIESKNYASLSNFIRDKKLDRCDETVKLLEKLPRLFGNLEVIEEAEKLASSNEMKMAITRVKEIYEAIEKLGYGSYISIDLGMIQHLDYYTGVIFKGYIYEIGEEIVSGGRYDELIGNFGEMLPAVGLAVQVNQIVKALQEQQEPYERKRIDIMIHYELNRLAEAERLRNLLQKDGKKVALSLFSNLNDTFQFARKNQIVTVVEAKSESLVEYVWKEKWVVQKEGETSCVTFKLR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_SHEB8
Sequence: MRTENTATLNLIWGALILEELARLGVQHVCMAPGSRSTPLTLAAAQQTKLQRHLHFDERGLGFMALGLAKASRAPVAIITTSGTAVANLYPAIVEAWLTHVPLIVLSGDRPPELLGCGANQAIVQPGIFANYATQVNLPTPDMHIAPQALLTTVDEAVANQTRPVHINCMYREPLYPSELGGAILDAESPYLKPLQTWLQLARPYTQYGKSKQLSSPSDDAIMRFVHGKGVIVVGTLTPEQDPQQLIALSQKIGWPLLTDAQSQLRQHPAAIGNIDQLLQHPRARNLLQEADRVLVFGGRLLSKRVISYLAEQNWHSYWQVLPEQDRLDPSHNAKHIWHANAEQFAALNWYRSSSANWANTLITYNDELHHLFVRNIDQGEFGEAQVIRAIANTRPLEQQLFIGNSLPVRLYDMYAPVSCCTATTYTNRGASGIDGLLATACGIAAHEGKPTSLIIGDLSQLHDLNSLAIAKGLSSPLVIVILNNDGGNIFNLLPVPNEQVRSDYYRLSHGLEFGYAAAMFNLPYNQVDNLADFQDSYNEALDFQGASIIEVNVSQNQASDQIAALNLWVKQS
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.