PharMolix/UniProtQA huggingface dataset:
Protein: PPIA_AOTTR
Sequence: MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFDDENFILKHTGPGILSMANAGPNTNGSQFFICTVKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQL
What is the function of this protein?
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity).  Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity).  Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity).  In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity).  Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity).  Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity).  Plays an important role in platelet activation and aggregation (By similarity).  Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).  Binds heparan sulfate glycosaminoglycans (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Protein: RHG23_MOUSE
Sequence: MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSSGRPLPWPGPRTLLLRKSLQDGFGFTLRHFIVYPPESAVHCILKEEENGGRGGGPSPRHRLEPMDTIFVKNVKDGGPAHRAGLRTGDRLVKVNGESIIGKTYSQVIGLIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPLCYPRKTYAPPTRAPAWATMVPEPISALPPDPRSPAAWSDPGSRVPSATRAHLDNSSLGMSQPRPSPGAFPHLPSESRTPRAFPEPGSRVLPSRLECQQALSHWLSNQIPRRAGERRCPAMPPRARSASQDRLEDVTTHHPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRLERCGWASQRPSARTSACPSRDLTQAPPPSGLQGLDDIGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFSLAQSPASFPPEASEPPRVVRPDPSTRALEPPAEDHRDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEARGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFALSRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPSRVPSLRVLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGGGLRQWKRVYAVLRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQTAVRGLRTQEQPPGSKEDSVAAPKTPWGINIIKKNKKAAPRAFGIRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPSDINLQDERWQDLNVISSLLKAFFRKLPEPLFTDDKYNDFIEANRIEDSRERMKTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDDEDKGERTPVDDKEPQSVPNIEYLLPNIGRTVPPSDPGSDSTTCSSAKSKGSWVPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKAAVGTQEPPEGQLPGPAAEEAPGRLSPPTAPDERPAADTRSIVSGYSTLSTMDRSVCSGTGGRRAGAGDEADDERSELSHVETDTEGGAGPGGRLSRRPSFSSHHLMPCDTLARRRLSRSRAEAEGPGAGTARACPRGPEPPGSASSSSQESLRPPAAAPALGSRPSRVEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPQESVGVRPHSDNKDSGLSSLESTKARASSAASLPSGDLGALQGLPQRRSAAARLHQCL
What is the function of this protein?
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
What are the official names of this protein?
Rho GTPase-activating protein 23, Rho-type GTPase-activating protein 23.
Protein: ILVD3_BRADU
Sequence: MKLRCPAAYGTSHVDDANMKKLRSRITTDGLDRAPHRAFMRAMGLDDAAIAKPMVGIVSMKGEQTPCNMTHDFQVAAAKTGIEEAGGTPREFSTVSVSDGISMNHEGMKFSLFSRELIADSIEAVVHGLAYDALIGYGGCDKTLPGVMMGMVRCNVPSIFIYGGSSLPGRVDGRTLTVLDSYEAVGSFMTGEIDSATLERIERACLPTIGACAGQFTANTMGMVSEAMGLTIPNVSMVPGVYAERAQISRRAGRLIMEMLERGGPLPRDIVTRKSLENGAAIVAATGGSTNAALHLPAIANEAGIAFTIDDVGEVFARTPLIGNLRPGGKYTAKDVHDIGGAAVVIQELIRTGHIDGNCITITGRTLAEEYGAANAPDGEVVYAASAPIMPDGGVAVLKGNLCPDGAVIKVAGLKSQFFEGVARVFEDEEACVAAVRDRSYKAGEVLVIRNEGPVGGPGMREMLGVTALIYGQGMGEKVALITDGRFSGATRGMCIGYVSPEAFVGGPLALVRDGDKIRIDATNRRMDMLVDEPELAARRRDWKPRPPRHRAGALAKYARLVGQAPGGAVTHEGPAEWPWFE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase 3, DAD 3.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: SPC25_DROSI
Sequence: MAIIMAESSYERRVKALYEKQIRMEALEAKFIKKVYKFNSNLLDVKEAACRHQRKVGKLQKVLMERREELDKRVSFIEELDRELEATKLRDLAMKDRIKQQKMLARQRKNEIMESIHTLSKTTETYINQDALPARVKGVTVLRGDKRNQLIPFDLKSTDVEGLDSLCQHLESLNVDIAQWQQLISLAMDVAMESRAPTTPPKEAANCNSIIEIDLTSPTCHI
What is the function of this protein?
Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis.  Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.  Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics.  The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
What are the official names of this protein?
Kinetochore protein Spc25.
What is the protein family that this protein belongs to?
Belongs to the SPC25 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore.
Protein: Y2232_ARATH
Sequence: MENFCFQDSVSLFITIMVLVLLPRLSLSDTSTYTRPENFYVNCGSDSNVFYGGQTFVGDTNSSTNSVSFTNKGTEVINDQSSVAPEIYRTVRIFRHPSSYKFKLDSLGLHFVRLHFSVVFSRADLLTARFTVSATSGSNHHLKSFSPQNLTNTPRVEEFLLMMNSLEFEIRFVPDHSSLALINAIEVFSAPDDLEIPSASDKNLHTIYRLNVGGEKITPDNDTLGRTWLPDDDDFLYRKDSARNINSTQTPNYVGGLSSATDSTAPDFVYKTAKAMNRSSNEQVGMLMNVTWSFKVKSNHRHFIRIHFSDILSNLSNSDSDFYLFVNGYWRVDVKPSEQPRLASPFFKDVVNVSDGSGLLNISIGTKEANKDAGFLNGLEMMEVLSKSGSDYSNRSSSRVHIITGCAVAAAAASALVFSLLFMVFLKRRRSKKTKPEVEGTVWSPLPLHRGGSSDNRPISQYHNSPLRNLHLGLTIPFTDILSATNNFDEQLLIGKGGFGYVYKAILPDGTKAAIKRGKTGSGQGILEFQTEIQVLSRIRHRHLVSLTGYCEENSEMILVYEFMEKGTLKEHLYGSNLPSLTWKQRLEICIGAARGLDYLHSSGSEGAIIHRDVKSTNILLDEHNIAKVADFGLSKIHNQDESNISINIKGTFGYLDPEYLQTHKLTEKSDVYAFGVVLLEVLFARPAIDPYLPHEEVNLSEWVMFCKSKGTIDEILDPSLIGQIETNSLKKFMEIAEKCLKEYGDERPSMRDVIWDLEYVLQLQMMTNRREAHEEDSTAINSGGSLVAPRLMVSDSFSTNSIFQNGDESKNRFGFTDSSETRVFSQLKISDAR
What are the official names of this protein?
Probable receptor-like protein kinase At2g23200.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: Y195_STRS2
Sequence: MMNMQNMMRQAQKLQKQMEKSQAELAATQFTGSSVQDLVTATFTGDKKLVSIDFKADVVDADDLETLQEMTIQAVNAALTKVDEATQKKLGAFAGKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein SSU98_0195.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: SCL5_ARATH
Sequence: MRLSVFIIPLVESRQASGIINKQSTSLLIRFSLYLEASISTKSFFSKSQRISQTQSPICLSANYYQPDNLDMEATQKHMIQEGSSMFYHQPSSVKQMDLSVQTFDSYCTLESSSGTKSHPCLNNKNNSSSTTSFSSNESPISQANNNNLSRFNNHSPEENNNSPLSGSSATNTNETELSLMLKDLETAMMEPDVDNSYNNQGGFGQQHGVVSSAMYRSMEMISRGDLKGVLYECAKAVENYDLEMTDWLISQLQQMVSVSGEPVQRLGAYMLEGLVARLASSGSSIYKALRCKDPTGPELLTYMHILYEACPYFKFGYESANGAIAEAVKNESFVHIIDFQISQGGQWVSLIRALGARPGGPPNVRITGIDDPRSSFARQGGLELVGQRLGKLAEMCGVPFEFHGAALCCTEVEIEKLGVRNGEALAVNFPLVLHHMPDESVTVENHRDRLLRLVKHLSPNVVTLVEQEANTNTAPFLPRFVETMNHYLAVFESIDVKLARDHKERINVEQHCLAREVVNLIACEGVEREERHEPLGKWRSRFHMAGFKPYPLSSYVNATIKGLLESYSEKYTLEERDGALYLGWKNQPLITSCAWR
What is the function of this protein?
Probable transcription factor involved in plant development.
What are the official names of this protein?
Scarecrow-like protein 5, AtSCL5, GRAS family protein 6, AtGRAS-6.
What is the protein family that this protein belongs to?
Belongs to the GRAS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECY2_STAA8
Sequence: MLKLLQQYEYKIIYKRMLYTCFILFIYILGTNISIVSYNDMQVKHESFFKIAISNMGGDVNTLNIFTLGLGPWLTSMIILMLISYRNMDKYMKQTSLEKHYKERILTLILSVIQSYFVIHEYVSKERVHQDNIYLTILILVTGTMLLVWLADKNSRYGIAGPMPIVMVSIIKSMMHQKMEYIDASHIVIALLIILVIITLFILLFIELVEVRIPYIDLMNVSATNMKSYLSWKVNPAGSITLMMSISAFVFLKSGIHFILSMFNKSISDDMPMLTFDSPVGISVYLVIQMLLGYFLSRFLINTKQKSKDFLKSGNYFSGVKPGKDTERYLNYQARRVCWFGLALVTVIIGIPLYFTLFVPHLSTEIYFSVQLIVLVYISINIAETIRTYLYFDKYKPFLNQYW
What is the function of this protein?
The central subunit of a protein translocation channel (Potential).  Part of the accessory SecA2/SecY2 system specifically required to export SraP, a serine-rich repeat cell wall protein encoded upstream in the same operon.
What are the official names of this protein?
Accessory Sec system protein translocase subunit SecY2.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family. SecY2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRMA_CAMJE
Sequence: MSLENFGNFLTLDEKHSFIKKYFKEFYTKDFKLFASKDKHYRTRAELSFYHENDTLFYAMFDPKSKKKYIIEYLDFADEKICAFMPRLLEYLRQDNKLKEKLFGVEFLTTKQELSITLLYHKNIEDIKSNLENLSNILHINLIARSKGKKLIFKTENLRQTLNIQDRKIFYEFNNDCFIQPNTAINEKMITWVCEILNTQKRMDLLELYCGYGNFTLALAPFFFKILATEISKSNINFALKNCELNNTTNIHFARLSSEELSLAIKKEREFFRLKDIRLDDFNFSHVLVDPPRAGLDKSVIDLIKKYGNIIYISCNPMTLKENLKELSLTHRVEEFALFDQFVNTPHLECGVFLSKV
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: RNPH_ANADF
Sequence: MRTNGRGPRDLRNVVLEPGVSKHAEGSCLARFGDTHVLCTASVDEKVPPHVYGTGAGWVTAEYGMLPRSTHERMAREAARGKQGGRTLEIQRLIGRALRAAVDLRALGTRTVTLDCDVIQADGGTRTAAITGGYVALALALRGLQQRKTLSRNPLARSVAAVSVGLVEGEVCVDLDYGEDSTAEVDMNVVATGDGALVEVQGTAEGKPFPRSDLDRMVDAALEAIGRLKERQEQALRG
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: FENR_POLNA
Sequence: MEPQLNQEVINTAALHDGPIETDAVIVGAGPVGLFQVFELGLLEIKAHIIDSLAYPGGQPIELYPDKPIYDIPAIPVCTGKELTDNLMKQIEPFGPTFHLGQEVSVLEKQEDGRFFVETSKGTKFLTKTIFIAAGVGAFQPKLLRVDGLDKFDNSQLFYRVKNPADFAGKNLIIVGGGDSALDWALNFVAEGPNKAESVILIHRRDGFKAAPANVAKMKELCDAYEMQFIIGQVTGYDEKEGRLTAAKVTGADGITRVVPLDVMLVFFGLSPKLGPIAHWGLDIERKQIKVDTEKFSTNIPGIFAVGDINTYPGKKKLILSGFHECALAAFGAAPFIFPDKKIHLQYTTTSPKLHKVLGVESPVFD
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: EFTS_BURP1
Sequence: MAAITASMVAELRAKTDAPMMECKKALTEADGDMAKAEELLRVKLGNKASKAASRVTAEGVVASFVGANAGALVELNCETDFVAKNDDFNAFAKTVAELVATQNPADVAALSALPLDGKTVDEVRLALVGKIGENISIRRFVRFETSNKLATYLHGSRIGVIVEYTGAQEQVGKDVAMHVAAMKPVSLSADEVPADLIEKERRVAEQKAAESGKPAEIVAKMVDGSVQKFLKEVSLLNQPFVKNDKQTIEQMLKAADAAVQKFALFVVGEGIEKRQDDFAAEVAAQVAAAKQQ
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBR2_ARATH
Sequence: MQGPRSTGDSSTGINYADGEPICSTNSETTSNNILNPVDVQFPNNTTGSGRPTYASSSSHVVQNHNWWSFGESSSRLGPSDHLNSNGSKTDRQLLSDGYGFEEGQSGMLLPGESFLRGSSSSHMLSHVNLGKDMDIGSGLQTSGVVIRHNNCETSLGSSSQTAEERSSGPGSSLGGLGSSCKRKALEGAPSHSFPGESHGCFFQTENGAWNEGLAQYDASSSLSLSMPSQNSPNVNNQSGLPEPRFGLGGGRAVTASAFPSTRSTETISRPGRRLNPGQPPESVAFSFTQSGSSVRQQQQLPATSPFVDPLDARAIPVTGSSSSGDGQPSMIHLPALTRNIHQFAWSASSSSRANSMPEEGLSPWDAPRINSEQPVFTTPANETRNPVQDQFCWSFTRGNPSTSGDSPFVPRAGSSSGIHGLQPNPTWVTPHNQSRISEVAPWSLFPSIESESATHGASLPLLPTGPSVSSNEAAAPSGSSSRSHRSRQRRSGLLLERQNDHLHLRHLGRSLAADNDGRNRLISEIRQVLSAMRRGENLRFEDYMVFDPLIYQGMAEMHDRHRDMRLDVDNMSYEELLALGERIGDVSTGLSEEVILKVMKQHKHTSSAAGSHQDMEPCCVCQEEYAEGDDLGTLGCGHEFHTACVKQWLMLKNLCPICKTVALST
What is the function of this protein?
E3 ubiquitin-protein ligase that functions as regulator of MED25 stability by targeting MED25 for degradation in a RING-H2-dependent way.  Proteasome-dependent degradation of MED25 seems to activate its function as positive regulator of FLOWERING LOCUS T (FT) and is important to induce the expression of FT and consequently to promote flowering.  May function downstream of HAL3 and be required for HAL3-regulated plant growth.  Activation of MBR2 by HAL3 may lead to the degradation of cell cycle suppressors, resulting in enhancement of cell division and plant growth.
What are the official names of this protein?
E3 ubiquitin-protein ligase MBR2, HAL3-interacting protein 1 homolog, AtHIP1, MED25-binding RING-H2 protein 2, RING-H2 finger MBR2, RING-type E3 ubiquitin transferase MBR2.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family.
Protein: AP3B1_HUMAN
Sequence: MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVLSQG
What is the function of this protein?
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes.  The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.  AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.  In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
What are the official names of this protein?
AP-3 complex subunit beta-1, Adaptor protein complex AP-3 subunit beta-1, Adaptor-related protein complex 3 subunit beta-1, Beta-3A-adaptin, Clathrin assembly protein complex 3 beta-1 large chain.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: UNG_RUEST
Sequence: MAPQDHASALRPAVGGWAELPFFETHWPRIEAALAQETRQILPPAHQRFAALERTPPESTRVVILGQDPYPTPGHAHGLSFSVEPDVTPLPRSLRNIYQEMRDDLGTCPETGDLRPWAAQGVLLLNTVLSVPAGEANGHKSLGWQELAHQVLDLSSRRPTAYVLWGNQAQKLESHIRPGDHLIVKTAHPSPLSARRGFFGSRVFSAINDWLTARGEPPITWADPRPAQGSIFDV
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_STRP8
Sequence: MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVVFPGVTRGSKLEEAINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKDLLEKSNGKLILPVDSKEANAFAGYTEVRDTEGEAVSKGFLGLDIGPKSIAEFDQALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: I20L2_HUMAN
Sequence: MSTLLLNLDFGEPPPKKALEGNAKHRNFVKKRRLLERRGFLSKKNQPPSKAPKLHSEPSKKGETPTVDGTWKTPSFPKKKTAASSNGSGQPLDKKAAVSWLTPAPSKKADSVAAKVDLLGEFQSALPKINSHPTRSQKKSSQKKSSKKNHPQKNAPQNSTQAHSENKCSGASQKLPRKMVAIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVNATPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHPKSLTRDTSHIPPLNRKADCPENATMSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMELYKLVEVEWEEHLARNPPTD
What is the function of this protein?
3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA.  Displays a strong specificity for a 3'-end containing a free hydroxyl group.
What are the official names of this protein?
Interferon-stimulated 20 kDa exonuclease-like 2.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ATG9_CRYGA
Sequence: MRKLCGNGSTSMISTDSYKNTTFFVIAFSTFLISCIDYTKLFSSLSTPEAVGRLEDVLIGQCITKGSFAHTLFLIILSAFFIFQVANFAMSVPRLLDMYRFYTHLLGVPDADIQTLPWPEIVRLIGDIRKHNPVTSLSNGQATALADMVGNDAKAPVKKLDAHDIANRILRQENYLIALFNKDLLDLRVRIPVPHIFTAFIPSSMLILSADPPLPSLQSEPERKFLSFGANHLTKALEWNLRFCLLGYLFDRRGQVRKEFVREKRRKDLVQGLRRRFVFMGILNAIFAPFIILYLLIYSFFRYFEEYHKNPSSIGSRQYTPYAQWKFREFNELPHLFERRLDRSYETAKEYVDQFPKERTALVMRFVAFVAGSFAAVLLVASLIDPDLFLHFEITPHRTVLFYLGVFGSVLAISRGMVPQENMVFDPEASLNEVVRWTHYLPVEWRGQLHSQMVHQEFSKLFALKIMIFFSELLSVILTPFILFFSLPPCAAAIIDFFREFTVHVDGVGYVCSFAVFDFARHGNIDSNRPETGVQGATGPDAGDSGGGGGGGGGGFAAGKSGRQTTRRAASASPSRFKQKDWRSNENKMEQSFLHFKATHPDWQPSDPSSSLFLDRLMGAGARNRPAGGISGSIYGGGGGGGGGGGRGLGIDGSVMAEMEEERLRAKSQSYERAWAKSSHLHRPDISNPLRHPHSAASEIIEEEEGGEGDKGDDSIDGWSKRMKTDGESDDEQEEHGRLWKDDGVQIDIKQ
What is the function of this protein?
Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation.  Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome.  Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.  Required for mitophagy.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.
What are the official names of this protein?
Autophagy-related protein 9.
What is the protein family that this protein belongs to?
Belongs to the ATG9 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RBSA2_AGRFC
Sequence: MGEVILSMTNIHKAFGPVRALRSAALELQRGEIHALAGENGAGKSTLMHIIDGILQPDGGEILLDGKPVRISSPNAANRLGIGFVHQEIALCPEISVAENMYMSETGQSRSWFMNYRDLEKRAATVLREIGDIDPTHRAGDLSISQQQIVEIAKALTLDCRILILDEPTAALTETEAQTLFKIMRRLAARGIAIIYISHRMAEIFEHCDRITVMRDGCHIRTENIADISPEEVVNSMVGRVLDKLYPPKLADDEKSNEVILSVRGLNEGKRVFDVDFDLRRGEILGFAGLIGAGRSEIARAVCRLEGKPKGEVVLRGRSLKLRDYRDSIREGIVYLSEDRKGDGLFLNMSIATNVSALDIGRISNGMGFIQRRKEMKRADELGRRLKLRANSVGDAVSTLSGGNQQKVALAKMLSVEPEVIFLDEPTRGVDVGAKAEIHRQIRELARQGVGVVVISSELPELIGVSDRVLVVREGRITGEVEGDDMTEEKIMQLASITIMQNAAEA
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UPP_STAAT
Sequence: MSKVHVFDHPLIQHKLSYIRDVNTGTKEFRELVDEVGMLMAYEVTRDLELQDVDIETPVTKMTAKRLAGKKLAIVPILRAGLGMTDGILSLVPAARVGHIGLYRDPETLKAVEYFAKLPQDITERQIIVVDPMLATGASAIEAITSLKKRGAKNIRFMCLIAAPEGVEKMHEAHPDVDIYIAALDEKLNDKAYITPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.