PharMolix/UniProtQA huggingface dataset:
Protein: IFNG_MERUN
Sequence: MNATHCILALQLCLLAISGCSSQVPIIEEIENLKRYFNSSNSAVGDSKDVVLHVLRNWQEDGDTKVIDVQIVSFYFKLFEALKGNQAIEKSINAIRADLIANFFNNSEAKYDGFMSIMKIEVNDPQIQSKAINELVKVMGHLSPRVTLRKRKRSRCCFGGGNRLNKNNPASTI
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: 3HAO1_ASPFU
Sequence: MLPPALNIPKWLEENSHLLQPPVNNYCVYHPSSPATAGYTVMIVGGPNARTDYHINTTPEFFYQYRGSMLLKTVDTSVSPPVFQDIPIHEGSIFLLPANTPHCPVRFKDTVGVVMEQPRPKDAVDTMLWFCKKCGEVVWEKRFVCTDLGTQVKEVVEEFAADQEKRTCKACGTIAETRYQEGEVVQPPRFLE
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase 1, 3-hydroxyanthranilate oxygenase 1, 3-HAO-1, 3-hydroxyanthranilic acid dioxygenase 1, HAD-1, Biosynthesis of nicotinic acid protein 1-1.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP2_ASFK5
Sequence: METFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCPALLKIFDELIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPIVKHEQASLIAKRDVYVPEVASCYFLAGTNINKAKDCIKGGTNGVGLKLAMVHSQWAILTTADGAQKYVQHINQRLDNIEPPTITPSREMFTRIELMPVYQELGYAQPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCSTSSVMALAKMYTLVTAPNSTIYTTTIKADAKPYSLHPLQVAAVVSPKFKKFEHVSIINGVNCVKGEHVTFLKKAINEMVVKKFQQTVKDKNRKTTLRDSCSNIFVVIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTRSIVDILLQSISKKDNHKQIDVDKYTRARNAGGKKAQDCMLLAAEGDSALSLLRAGLTLGKSNPSGPSFDFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVLGLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQLIVHGFVKRLLTPLIRVYEKGNTVPVEFYYEQEFDAWAKKQTSLANHTVKYYKGLAAHDTHEVKSMFKHFDKMVYTFTLDDSAKELFHIYFGGESELRKRELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLDGMTRARRKILAGGLKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSIIKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKTMFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWARQLEDILALVRAYIDKNNPKHELLHYAIDHKITVLPLRPSNYNFKGHLKRFGQYYYSYGTYVVSEQRNMITITELPLRVPTVAYIESIKKSSNRMAFIEEIVDYSSSETIEILVKLKPNSLSRIIEEFKETEEQNSIENFLRLRNCLHSHLNFVKPKGGIIEFNSYYEILYAWLPYRRDLYQKRLMRERAVLKLRIIMETAIVRYINESADLNLSHYEDEKEAGRILSEHGFPPLNQSLITSPEFATIEELNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQESPFPGASVWLEEIDAVEKAIIKGRNTQWKFH
What is the function of this protein?
Type II topoisomerase.  Processively relaxes supercoiled DNA.  Displays DNA-supercoiling activity only when associated with the viral histone-like protein.
What are the official names of this protein?
DNA topoisomerase 2, DNA topoisomerase II.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Localizes throughout the cytoplasmic viral factories at 16 hpi.
Protein: MIAA_BUCCC
Sequence: MNKKKFLFFLMGPTAIGKSSLALEIKKKFPLIELISVDSKLVYKGLNIGTDKPNKSDLKNFSYKLVNIVKPKNIYTVINFYNDVLKEIKNILKSGKIPLLVGGTMLYFKILLNGFANLPPSNSIIRKYIFKNICLKKKKNLFNLLKKIDPISSKKIHINDVQRVLRAVEVFFVSGGFPLSELIKFFHNKLPYKVFQFGLIPDNKEHLYKKIEKRFFFMLKSGFKKEVQNLYNQKFLDPKLPSMNSIGYKQMLLYLKNKYTYFQMIKETIKSTHKLVKHQLTWLKKWPNIIFIKDNKKDLLITKIYKILNRNL
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: NUOI_RHILW
Sequence: MGSLSSSISSLFLKEFFGAFFLSMRYFFRQKATINYPFEKGPVSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYFDKARLLDNGDRWEREIARNIAIDSPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RPOA_RICAH
Sequence: MLSLSKNWNTLIKPNRVAYENFPEINNKAKIVVEPLERGFGLTLGNAMRRVLLSSLQGAAITSIKIPAIEHEFSSIPGVKEDVSEVILNIKGVELKMHVAEKRIMKLKATGPCVVTAGMIETGHDVEILNPDHIICNLAKNKQLEMALTCKVGKGYVLSTNSYEDDLPIGEIAIDALFNPVKSVTYKVENTRVGQVTDYDKLIMFVETNGGLLPEMAVGLAARILQEQLQLFISFEEHEEDKQVKTDTLPFSPYLLKRVDELELSVRSANCLKNDNIIYIGDLVKRTESDMLRTPNFGRKSLNEIKEILAKFNLRFGMDVPDWPPENIQELSKRYEDSYN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RIMP_SHEB5
Sequence: MATLEFRLAEMLKVPVEALGFQLWGIEYVQAGKHSTLRVFIDGENGINIEDCANASRQVSAVLDVEDPISTEYTLEVSSPGVDRPLFTAEQYAGYVGEDVKLQLTMPVDGSRNLKGAITAVDGQMLSLKVNGKELVVALDNIRKGNLIAKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF6_YEAST
Sequence: MATRTQFENSNEIGVFSKLTNTYCLVAVGGSENFYSAFEAELGDAIPIVHTTIAGTRIIGRMTAGNRRGLLVPTQTTDQELQHLRNSLPDSVKIQRVEERLSALGNVICCNDYVALVHPDIDRETEELISDVLGVEVFRQTISGNILVGSYCSLSNQGGLVHPQTSVQDQEELSSLLQVPLVAGTVNRGSSVVGAGMVVNDYLAVTGLDTTAPELSVIESIFRLQDAQPESISGNLRDTLIETYS
What is the function of this protein?
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm.  Is also involved in ribosome biogenesis.  Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.  Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1.  Also required for pre-rRNA processing.
What are the official names of this protein?
Eukaryotic translation initiation factor 6, eIF-6.
What is the protein family that this protein belongs to?
Belongs to the eIF-6 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
Protein: ISPDF_SULNB
Sequence: MPDITLILLGAGNSTRFESDVKKQWLYSGEIPLWLHVAESFEAMGAFAKIVIVSSPEDIGLMKHFADYTYVQGGETRQASLKNALEDVTTEYVLVSDIARCCVPAAMIHRILDAREEASCIVPVLPVTDTLYLAQTPLDREQVRIIQTPQLSVTKTLKQALQTDQLFTDDSSAVASMGKKVHFVEGSHEAHKLTTISDLKKLPCIEAPSGKTLTGFGLDIHPFEEGKAMVLCGVKIAVDYGFKAHSDGDVAIHALIDALLGAAGMGDIGELYPDTDQSYAGANSTRLLSDTVRKIRTHGYTIGNVDMTILAQAPRLLPYKEKMKHSIASLLEIRPHLVNIKATTAEKLGFVGRKEGVTVHAVANLTYYNWKQK
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: NUSB_LACLA
Sequence: MFQIELDEEPVAPKVLEFFKNLPENATAEQSLETFQKTFSFLHENVLEKYTSDLFTPSTLKEELDEQLAQAENNAQSQLSELLKNTKRFVLNYDNDRPEDLEAPEYFTQLVDGVLDKKEDLEANISKYLTKTWSFSRLTLVEQAILQVSSYEILYTETPDVVAVNEAVELSKDFSDEKSSRFINGVLTNFLK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: LEU3_BUCUH
Sequence: MKQKYRIAILPGDGIGPEVMREAYKILSILKDHFSLSLEIQEFNIGGSAIDQEGIALPKKTLLGCQNSDAILFGSVGGKRWDHLPINERPERASLLPLRKHFNLFANLRPAKLYSELQHLSPIRSNIIKNGFDILCVRELTGGIYFGKPSDRVKKNNVEYAFDTEVYYDYEINRIAHLAFQLARTRKFKVCSIDKSNVLNSSILWREVVEKVSKMYPDVHLSHLYIDNATMQIIKNPNQFDVLLCSNLFGDIISDECAVITGSIGMLPSASFNEKNFGLYEPAGGSAPDIAGKNTANPIAQILSLSMLVRYGMKLNKIADKIDDAVALSLKAGYRTADISNDNNFLKTNEMGDVIANFLINGK
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCR1_DEBHA
Sequence: MSFTRQLTKNLTSFKVLAPFAAAVGSVGIAYQYSTSSIMNETGKTFTGNDEWIDLKLAKSWDTTHNTKHFVFELANQDDVSGLINASCLLTKFVTPKGNNVIRPYTPISDVDGKGSIEFVIKKYDGGKMSSHIHDLKPNDTLAFKGPVVKWKWEPNQYKSIALIGGGTGITPLYQLMHEITKNPEDKTKVNLFYGNLTEKDILIKKELDTIAEKHKDQVNVVYFLDKAPENWNGETGYISKEFLQSKLPGPGKDNKVFVCGPPGLYKALSGPKKSPTDQGEVEGALADLGYTKENVFKF
What is the function of this protein?
May mediate the reduction of outer membrane cytochrome b5.
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: CT56_CONLT
Sequence: MLCLPVFIILLLLASPAAPKSLETRIQNDLIRAGLTDADLKTEKGFLSGLLNVAGSVCCKVDTSCC
What are the official names of this protein?
Conotoxin Lt5.6, Lt5f.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YCNI_BACSU
Sequence: MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYTMKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQEGQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTDEHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA
What are the official names of this protein?
Uncharacterized protein YcnI.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NA13_BUNGR
Sequence: GASCRCDSDGPTSRGDTLTGTLWLIGRCPSGWHNCRGSGPFIGYCCKQ
What is the function of this protein?
Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.  Has effect on SCN4A/SCN1B, and SCN5A/SCN1B, has no effect on SCN2A/SCN1B, and SCN10A/SCN1B.  Possesses the highest efficacy for the insect sodium channel para/tipE.  Also interacts with sodium channels in cardiac cells.  Shows lethality to crabs (PubMed:22015268).
What are the official names of this protein?
Delta-actitoxin-Bgr2b, Delta-AITX-Bgr2b, Bg III, BgIII, Neurotoxin Bg-3.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: TRPB_SERP5
Sequence: MTLLNPYFGEFGGQYVPQILMPALKQLEEAFVSAQRDPEFQAEFIDLLKNYAGRPTALTLCRNLTAGTKTKLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTEIIAETGAGQHGVASALACALLGLKCRIYMGAKDIERQSPNVFRMRLMGAEVIPVHSGSSTLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQMLEREGRLPDAVLACVGGGSNAIGMFADFIDDTSVGLIGVEPAGLGIETGQHGAPLKHGHVGIYFGMKAPMMQTSEGQIEESYSISAGLDFPSVGPQHAYLNSIGRAEYVSITDDEALDAFKALSRSEGIIPALESSHALAHALKMIRETPQKEQILVVNLSGRGDKDIFTVHDILKARGEI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: ADA2A_RAT
Sequence: MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
What is the function of this protein?
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
What are the official names of this protein?
Alpha-2A adrenergic receptor, Alpha-2A adrenoreceptor, Alpha-2A adrenoceptor, Alpha-2AAR, Alpha-2D adrenergic receptor, CA2-47.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AMT1_SCHPO
Sequence: MSSTTDATPTPSGVNGGDSMTVNLNQFYNNGDVAWILTSTALVFIMIPGVGFFYSGLARRRSAISMLFLSMMSVAIVAFQWFFWGYSLTFSHEGGPYIGSLANFGLRQTLGRPSSGASSVPDILFCVFQGMFAAITPALAIGAAADRGRMFPCMVFMFLWTSIVYDPIAFWTWNPNGWLNKLGSYDFAGGSPVHISSGMAALAYSIVIGKRCDHGTTKYRPHNVPHVVLGTVFLWFGWFGFNGGSSAAANMRGVMAVVVTHLAASVGGIVWCVIDFAKNRHWSVVGFCEGAVAGLVAITPGSGFVPPWAAVVIGALGAVFCYAATYLKKIIRVDDALDIFAEHGVGGMVGNILTALFAADYIEALDGSGTAYTGGWITHHYIQLGYQLADTVSCAAYSFAVSCALLFVMNYIPGLSLRVSREDEVLGLDKIELGESAYYYKDSTDEPPPITTSGVQYTSPTVSDSASNEKEQEHRAQNEAQKEEEYRAESEAQAPAI
What is the function of this protein?
Transporter for ammonium to use as a nitrogen source.  Under ammonium limitation acts as an ammonium sensor, generating a signal that leads to pseudohyphal growth.
What are the official names of this protein?
Ammonium transporter 1.
What is the protein family that this protein belongs to?
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: DPS_SALPK
Sequence: MSTAKLVKTKASNLLYTRNDVSESDKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALTDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAVVANDVRKAIGEAKDEDTADIFTAASRDLDKFLWFIESNIE
What is the function of this protein?
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages.  It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_BRUA1
Sequence: MTTLENPEMQAQLLSAALPYMQRYENKHVVVKYGGHAMGNPELGKAFARDVALLKQSGVNPIVVHGGGPQIQAMLTKLGIESRFEGGLRVTDEKTVEVVEMVLAGSINKEIVALINAEGEWAIGLCGKDGNMVFAQKAHKTVIDPDSNIEKVLDLGFVGEPAEVDRTLLDLLARSEMIPVIAPVAPGRDGHTYNINADTFAGAIAGALAATRLLFLTNVPGVLDKDKKLIKELSVADAQALIRDGTISGGMIPKVETCIDAIRRGVEGVVILNGKTPHSVLLELFTEHGAGTLIVP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_LEPBA
Sequence: MKIKTDEVTSVLKQEIKNFKKDLQVEEVGTVLEVGDGIARVYGLTNVMSGELVEFQNGVRGQAFNLEENSVGVVIFGDYIKIEEGFSVKRVGKIFEVPVGPELLGRVLNPLGEVIDGKGPLNAKKTRPVESPAPGIAMRKSVHEPMQTGIKAIDAMIPIGRGQRELIIGDRGTGKTSIAIDTIINQKGKGVICVYVAIGQKASTVASTIEMLREKGALEYTIIVSANASEPAPMLYIAPYSGATMAEYFMYEEGKATLVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLDDKFGGGSMTALPIIETQEGEVSAYIPTNVISITDGQIYLQSNLFASGLRPAVDVGISVSRVGSAAQIKAMKKVAGTLKSDLAQFRDLEAFAQLGTELDPVTQAQLDRGYRVLEILKQPNNSPTPVEEQVISIFAVTKGFMDVVPTAKVREFEAFLLKTMREQHPEILEEIRTAKEVKQEAALQKTIKSIVEHFLAKNN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ENV_HV2D2
Sequence: MAYFSSRLPIALLLIGISGFVCKQYVTVFYGIPAWRNATVPLICATTNRDTWGTVQCLPDNGDYTEIRLNITEAFDAWDNTVTQQAVDDVWRLFETSIKPCVKLTPLCVAMNCSKTETNPGNASSTTTTKPTTTSRGLKTINETDPCIKNDSCTGLGEEEIMQCNFSMTGLRRDELKQYKDTWYSEDLECNNTRKYTSRCYIRTCNTTIIQESCDKHYWDSLRFRYCAPPGFFLLRCNDTNYSGFMPNCSKVVASSCTRMMETQSSTWFGFNGTRAENRTYIYWHEKDNRTIISLNTYYNLSIHCKRPGNKTVVPIRTVSGLLFHSQPINKRPRQAWCWFKGNWTEAIKEVKRTIIKHPRYKGGAKNITSVKLVSEHGKGSDPETTYMWTNCRGEFLYCNMTWFLNWVENKTNTTRRNYAPCHIRQIINTWHKVGKNIYLPPREGELSCNSTVTSLIANINSDNSTTNISVSAEVSELYRLELGDYKLVEITPIGFAPTDVRRYSSVKPRNKRGVMVLGFLGFLAMAGSAMGATSLTLSAQSRTLLAGIVQQQQQPVDVVKRQQELLRLTVWGTKNLQARVTAIEKYLKDQAQLNSWGCAFRQVCHTTVPWPNETLTPNWNNMTWQQWEKQVHFLDANITALLEEAQIQQEKNMYELQKINSWDVFGNWFDLTSWIKYIHLGLYIVAGLVVLRIVVYIVQMLARLRKGYRPVFSSPPSYTQQIPIRKDRGQPANEETEEGGGNDGDYRSWPWQIEYIHFLLRQLRNLLIWLYNGCRTLLLKTFQILHQISTNLQPLRLPVAYLQYGISWFQEALRAAARATGETLASAGETLWEALRRAARAIIAIPRRIRQGLELTLL
What is the function of this protein?
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers.  Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells.  Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells.  This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: RS6_STAAE
Sequence: MRTYEVMYIVRPNIEEDAKKALVERFNGILATEGAEVLEAKDWGKRRLAYEINDFKDGFYNIVRVKSDNNKATDEFQRLAKISDDIIRYMVIREDEDK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: MNTP_CLOB1
Sequence: MDLISVILISIGLSMDAFAVSITNGAMISKVTASEGIRIGLFFGGFQALMPLIGWSIGIKFESYIAALDHWIALILLSIIGGKMIYDSVKENQDHKDEIACDYAAGEKKCLNNKTLILLAIATSIDALAVGVSFAFLKVSIINTIIIIGSITFVICFIGVMIGKKCGKLLKKRAEILGGVVLILIGVKIFIQHTNILSYIF
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NADE_STRPN
Sequence: MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFVLGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAFIQPDVSLVVNIKESADAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGSHSGAVIGTDHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQKLGAEPALYEKIPTADLEEDKPGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFWE
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: HFQ_CAUVN
Sequence: MSAEKKQNLQDTFLNSVRKSKTPLTIFLVNGVKLQGVVSWFDNFCVLLRRDGQSQLVYKHAISTIMPAQPVQLYEPSADADD
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.