PharMolix/UniProtQA huggingface dataset:
Protein: CYB_SALSA
Sequence: MANLRKTHPLLKIANDALVDLPAPSNISVWWNFGSLLGLCLATQILTGLFLAMHYTSDISTAFSSVCHICRDVSYGWLIRNIHANGASFFFICIYMHIARGLYYGSYLYKETWNIGVVLLLLTMMTAFVGYVLPWGQMSFWGATVITNLLSAVPYVGGALVQWIWGGFSVDNATLTRFFAFHFLFPFVIAAATVLHLLFLHETGSNNPAGINSDADKISFHPYFSYKDLLGFVAMLLGLTSLALFAPNLLGDPDNFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSILVLMVVPILHTSKQRGLTFRPLTQFLFWTLVADMLILTWIGGMPVEHPFIIIGQIASVIYFTIFLVLAPLAGWAENKALEWT
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PDXT_METVS
Sequence: MKIIGILGIQGDIEEHEIAVKKINCIPKRIRSVSDLDEIDALIIPGGESTTIGKLMVKYGFIEKIRNLDIPILGTCAGMVLLSKGTGKEQPLLKILNVTIKRNAYGSQKDSFEKEIILDGKKLNAVFIRAPMVDKILEKTVEIISKDGESIVGVREGNIMAISFHPELSNDGIILYEYFLKNFVEKN
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: IP6K1_RAT
Sequence: MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTPEREQPRRKHSRRSLHRSGSGSDHKEEKASLSFETSESSQETKSPKVELHSHSDVPFQMLDSNSGLSSEKISYNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSASLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRSELRLKHVDMGLPEVPPLCGPSTSPSNTSLEAGPSSPPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ
What is the function of this protein?
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).  Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity).
What are the official names of this protein?
Inositol hexakisphosphate kinase 1, InsP6 kinase 1, Inositol hexaphosphate kinase 1.
What is the protein family that this protein belongs to?
Belongs to the inositol phosphokinase (IPK) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MGN2_ORYSJ
Sequence: MATGGAAGEDVPGGGEFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDTMIRKEVFVSPSVLREARRIIQESEIMKEDDNNWPEPDRVGRQELEIVMGNEHISFTTSKIGSLVDVQTSKDPEGLRIFYYLVQDLKCFVFSLINLHFKIKPIQS
What is the function of this protein?
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  The MAGO-Y14 heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation.  The MAGO-Y14 heterodimer interacts with the EJC key regulator PYM leading to EJC disassembly in the cytoplasm (By similarity).  EJC core heterodimers play essential roles in plant growth and development, and pollen and seed development (PubMed:25230811, PubMed:24820023).  The MAGO-Y14 heterodimer selectively binds to the UDT1 (UNDEVELOPED TAPETUM 1) pre-mRNA transcript and regulates the splicing of UDT1, a key regulator in stamen development (PubMed:24820023).
What are the official names of this protein?
Protein mago nashi homolog 2, OsMAGO2, Mago nashi-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the mago nashi family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: TSAC_SHIB3
Sequence: MNNNLQGDAIAAAIDVLNEERVIAYPTEAVFGVGCDPDSETAVMRLLELKQRPVDKGLILIAANYEQLKPYIDDTMLTDAQRETIFSRWPGPVTFVFPAPATTPRWLTGRFDSLAVRVTDHPLVVALCQAYGKPLVSTSANLSGLPPCRTVDEVRAQFGAAFPVVPGETGGRLNPSEIRDALTGELFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ER21A_XENLA
Sequence: MNIFRFLGDISHLSAIFILLLKIWKSRSCAGISGKSQLLFAIVFTARYLDLFTNYISFYNTSMKVVYVASSYATVWMIYSKFKATYDGNHDTFRVEFLIVPTAILAFLVNHDFTPLEIFWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGIYRTLYLFNWIWRYQFEGFFDLIAIVAGLVQTVLYCDFFYLYVTKVLKGKKLSLPA
What is the function of this protein?
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
What are the official names of this protein?
ER lumen protein-retaining receptor 1-A, KDEL endoplasmic reticulum protein retention receptor 1-A, KDEL receptor 1-A.
What is the protein family that this protein belongs to?
Belongs to the ERD2 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.
Protein: NADB_MYCLE
Sequence: MAVPDWKHAADVVVIGTGVAGLAAALAAHRAGRNVVVLTKADQRRGETATHYAQGGIAVVLPGSDDSVDAHASDTLAAGAGMCNLDTVYSIVAEGYHAVTELVGYGARFDESIPGRWAVTCEGGHSRRRIVHAGGDATGAEVQRALDHAADVLDIRTSHLALRVLHDGTVVNGVSVLNPNGWGIVSAPSVILASGGLGHLYGATTNPEGSTGDGIALALWAGVAVSDLEFIQFHPTMLFAAGTGTGGRRPLVTEAIRGEGAILLDSKGNSVTSGVHPLGDLAPRDVVAAAIDARLKATGDSCVYLDARGIDGFASRFPTVTAACRTVGIDPAREPIPVVPGAHYSCGGIVTDAYGQTELAGLFAAGEVARTGMHGANRLASNSLLEGLVVGGRAGRAAAAHAAAAGRAYVSKLEPVTHHALKRRELQRVMSRDAAVMRNAAGLQRLSDTLAEAPIRHVTGRRDFEDVALTLTARAVAAAALARNESRGCHHCTEYPDTAPEHARSTVIRLADDQNLVRAEALATVG
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPM_HUMAN
Sequence: MLETLSRQWIVSHRMEMWLLILVAYMFQRNVNSVHMPTKAVDPEAFMNISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATVKHAKSPGTKFLLLPDMMIKGLFGKKEFLYQTRFLRQLVIYLCGQVILDQICSNIMLLLGGFNTNNMNMSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKCNQPTPVRYRVRDMTVPTAMWTGGQDWLSNPEDVKMLLSEVTNLIYHKNIPEWAHVDFIWGLDAPHRMYNEIIHLMQQEETNLSQGRCEAVL
What is the function of this protein?
Plays a highly specific role in the last step of keratinocyte differentiation.  May have an essential function in lipid metabolism of the most differentiated epidermal layers.
What are the official names of this protein?
Lipase member M, Lipase-like abhydrolase domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: METAA_BRUA2
Sequence: MPIKIPDDLPATSVLEAEGVMVMREADAVRQDIRPLRIGLLNLMPNKVTTETQIARLLGATPLQVELTLVRMTNHVARHTPADHMLSFYCPWEEVNDQRFDGFVITGAPVERLPFEEVTYWDEMRRVFDWTQSHVHRTLNICWAAQAAVYHFHGMKKYDLPAKASGVFRQRSLVPASPYLRGFSDDFAIPVSRWTEVRKSDIPADSGLKVLVDSTETGLCLLDDPRHRSLHMFNHVEYDTTSLADEYFRDIQVQPEAKVPVNYFPGDDAKRPPENRWRSHAHLLFGNWINEMYQSTPYDIERIGKV
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_PSEP1
Sequence: MTLDRDAASHVAEVLSEALPYIRRFVGKTLVIKYGGNAMESEELKTGFARDIVLMKAVGINPVVVHGGGPQIGDLLKRLSIESHFIDGMRVTDSATMDVVEMVLGGQVNKDIVNLINRHGGSAIGLTGKDAELIRARKLTVSRQTPEMTTPEIIDIGHVGEVVSVNTDLLNMLVKGDFIPVIAPIGVGANGESYNINADLVAGKVAEALKAEKLMLLTNIAGLMDKQGQVLTGLTTEQVNELIADGTIYGGMLPKIKCALDAVQGGVNSSHIIDGRVPNAVLLEIFTDSGVGTLITNRKPR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_LACPL
Sequence: MKRPIIIALDFPTAERALAFLDQFPADLHVTVKIGMELFYAAGPSIVTDVQARGHAVFLDLKLHDIPNTVESAMRVIGRLGVTYTTVHAAGGHVMLSAAKRGLVAGAMAAGVTAPKLLAITQLTSTNQAILNQDQQIMGTVRASVVHYAKLARASDCDGVICSAQEVQAIHTAVGADFLGITPGIRPASAQSDDQQRVMTPAAAAKAGSNGLVIGRPITQAAEPVQAYRDIMTEWSN
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: DAPB_CITK8
Sequence: MHDAQIRVAIAGAGGRMGRQLIQAALGMDGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSLEAVKDDFDIFIDFTRPEGTLAHLAFCRQHGKGIVIGTTGFDDAGKQAIRDAAQDIGIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKACAVYSREGYTGERVPGTIGFATVRAGDIVGEHTAMFADIGERIEITHKASSRMTFANGAVRSAIWLKSKPNGLFDMSDVLNLNNL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSU_LACJO
Sequence: MNGIALLIGLGPLLGWGLFPTIASKIGGKPVNQIIGTTFGTFIFALVYNLVQGIALPSGAALIWSIISGIGWASAQILTFHSFTLVGSSRAMPITTAFQLLGTSLWGVFALGDWPSTSDKLVGFLALALIILGAWMTTWSEHKTDENSAKLRKAVIILLVGEIGYWAYSAAPQAAKIDGSKAFLPQAIGMCLVAICYAVYLKVKEPSQRSALAQGVSYKQIISGFFFAFAALTYLISAQPNMNGLATGFILSQTSVVLATLTGIWFLHEKKTKKEMVVTLIGLAIIIGAATMTVIV
What is the function of this protein?
Could be involved in the uptake of ribose.
What are the official names of this protein?
Putative ribose uptake protein RbsU.
What is the protein family that this protein belongs to?
Belongs to the GRP transporter (TC 2.A.7.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS3A_NANEQ
Sequence: MAYNKKYADWKRKIWFTIKAPAIFNEVELGETPAYKPEQVIGRRVELNMALVTNNYQLQNYKGIFKITKVEGTTAKTELEGIKMYESIIQKWVEPGRDKITDSFVIKDKDNRLVRVKPVLITNRRLHRKQGTAIRNIWRNYFVELGKKLSFEDMVMKILNKEIPEQLKIQIKKIYPPLFFAIRQFYLEPREKHILLIE
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: GLMM_RHOJR
Sequence: MGRLFGTDGVRGLANTELTAELALQVASAAATVLASPGSGGRKTAVVGRDPRASGEMLEAAVVAGLTSAGVDVLNVGVLPTPAVAYLTAALDAALGVMISASHNPMPDNGIKIFAAGGHKLDDEVEDRIEAVAAGTTTRRAPTGAGIGRVRTVPDAAERYLQHLATALPNSLDGLTVVVDCAHGAASGVAPAAYRAAGATVVAINAEPDGLNINENCGSTHLESLQKAVVEHGADLGLAHDGDADRCLAVDAAGSLIDGDAIMTVLALGMRDAGELVDNTLVATVMSNLGLHIAMREAGITLVTTAVGDRYVLEGLRSGGFSLGGEQSGHVVFPAFGTTGDGVLTGLRLMGRMAETGQAIADLASAMTALPQVLVNVRVADKRAVAASPVVLDAVVAAERSLGDNGRVLLRPSGTEQLVRVMVEASDIEVARKLADELAGTVASV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: TMEM9_MOUSE
Sequence: MKLLCLVAVVGCLLVPPAQANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARTMATAAASIGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS
What is the function of this protein?
Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (By similarity).  By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (By similarity).  TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568).  In the liver, involved in hepatic regeneration (PubMed:32380568).
What are the official names of this protein?
Proton-transporting V-type ATPase complex assembly regulator TMEM9, v-ATPase assembly regulator TMEM9, Transmembrane protein 9, Protein TMEM9.
What is the protein family that this protein belongs to?
Belongs to the TMEM9 family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein.
Protein: MSCL_HAEDU
Sequence: MSILKEFREFAVKGNVMDMAVGVIIGGAFGKIVSSLVSDVIMPPIGWLIGGVDFKDLAIQIAPAKEGAEAVMLKYGAFIQNIFDFLIIAIAVFSMVKAINSLKRPPEVAEAPAVAKGPTQEELLAEIRDLLKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYFA_SYNAS
Sequence: MIEDLKELQNKAEAEIKAAKTETDLAAVRVRYLGRKGLLTQFLRNLGQLSIEEKQIFGKRANEIKTILSSRFDEAQTVIAALKKESVLRAEALDVTLPGRSSGYGRAHPVTQVLEEICAIFSEIGFSIAEGPEIESDYYNFEALNIPKDHPARDMQDTFYVEEAIVLRTHTSPVQIRTMEKQSPPVKIISPGRVYRPDSDVSHTPMFHQVEGLLVDRGITFGDLKGLLNAFLKQIFGEETVLRFRPSYFPFTEPSAEVDIRCVICRGKGCRVCGQSGWLEILGSGMVDPAVFENVGYDPEEYSGFAFGLGVERIAMLKYGITDIRLFFENERRFLQQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GYRB_SYNY3
Sequence: MTMTTTNYGADQIQVLEGLEPVRKRPGMYIGSTGPKGLHHLVYEVVDNAIDEALAGYCTHIEIDINADGSVTVVDNGRGIPTDIHPTTGRSALETVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSEWVEVKVWRQGKEHFQRFERGNPIGTLEATPNEGHSTGTQVSFLPDTQIFKDGIEFDYHTLASRLKELAYLNAGVRITFGDRRADSLKEEQFYYEGGIREYVTYMTTDKTPLHEEIIYTSGEKNDVQVEVALQWCVDAYSDTLLGFANNIRTIDGGTHLEGLKAVLTRTLNSVARKRNKLKDGDSNLGGENIREGLTGVISVKVPDPEFEGQTKTKLGNTEVRGIVDTLVGEALTEFLEFNPGVADAIIEKAVQAFKAAEAARRARELVRRKSVLESSTLPGKLADCSSKDPSESEIFIVEGDSAGGCFSGDTLVALTDGRSVSFEQLVEEEKQGKQNFCYTIRHDGSIGVEKIINARKTKTNAKVIKVTLDNGESIICTPDHKFMLRDGSYKCAMDLTLDDSLMPLHRKISTTEDSGITIDGYEMVWSPRSDSWLFTHLVADWYNRWQGIYIAEEKQHCHHKDFNKRNNNPDNLIRLSPEKHLALHRKHISKTLHRPDVVEKCRRIHQSPEFRRKMSARMQSPETRAILSKQAQAQWQNETYKLTMMESWRSFYDSNEDYRQQNAEQLNRAQQEYWAQAENRTAQAERVRQHFAQNPGLRQQYSENAVKQWNNPELLKWRQKKTKEQWTPEFREKRREALAQTYYRKTLAALKQVEIENGYLDISAYDSYRISTKDKSLLRFDRFCERYFENDENLAREAVLNYNHRIVNIEAVSETIDVYDIEVPHTHNFALASGVFVHNSAKQGRDRRFQAILPLRGKILNIEKTDDAKIYKNTEIQALITALGLGIKGDDFDISSLRYHRVVIMTDADVDGAHIRTLLLTFFYRYQRDLVDQGYIYIACPPLYKLERGKNHFYCYSDRELQEQISQFPPNANYTIQRFKGLGEMMPQQLWDTTMNPESRTMKRVHIEDAAEADRIFTVLMGDRVAPRREFIETYGTKLDLTDLDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_ECODH
Sequence: MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RL29_CITBB
Sequence: MKANELKNATAAELEAKGTELTKELFNVKFQLHTGRLENTSKVSNLRKDIARVKTILREKRG
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: EFC14_MOUSE
Sequence: MKKRKELNALIGLAGDHRRKKTKQGSGSHRLLRTEPPDSDSESSTDEEEFGAIGNRSRFVKGDYARCCKICCPLCAFVILAACVVASVGLVWMQMALKEDLDVLKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGELGLSRVWINITEMNKQISLLSSAVNHLKASVKSAADLLSLPSTVEGLQKSVASIGNTLNSVHLAVEVIQKTVDEHRTTLGLLQGSMENNGSNQILPSPSPPSELDNKSHSESAKQDILYLHNSLEEVNSTVVEYQRQNDLKLKGMSETLSNLTQRLSLIESHVVALSKAEQRTNVSSSTMENRAATLKRESLVTNRSDTVQAQSMKKEDNSNSQVSELREKLQLISALTNKPESNRPPETTDEEQVQNFTSDPSALPEFSQLLRNQIETQVKPLSLPGISSIKDLQDLFHKTGQDVDGMLTYQELWNSLGSAMPRPESLRAFDSNGDGRYSFLELRLALGI
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 14.
Protein: VP2_BFPYV
Sequence: MGAIISAIAGLFELGALGGLAVDAAVNTAEIEAFIGELVLQDFSVAEIFDAIETSGIPLANTAVPVAELQQTAATSGLIGQALSAPSLIAASVKAFAGDPVAAGNNMALQVWRDQMDILFPGAEWFSNAVHNINPLAWAQSLYEQVGQSIWNYMTGNIGQAVIHQIEERTTALIVYQSRGIYDILARALETARWTLTTAAVDTYQTLKSYYGELPAVSGRVEAFRRYHEVAQGRSFFEDSDIQDVLEGKKAQKRIEGPQEMTGQTIEQQTPPGGAMQRHANDWLLPLILGLYGDLTPEWRYQLKERLNVPKRKRKLPTTSAGTSPPSKRRYRGVRRKVRSR
What is the function of this protein?
Structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers.  Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane.  Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2 or VP3 nuclear localization signal (shared C-terminus).  Plays a role in virion assembly within the nucleus (By similarity).
What are the official names of this protein?
Minor capsid protein VP2, Minor structural protein VP2.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses capsid protein VP2 family.
What are the subcellular locations of this protein?
[Isoform VP2]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane. SUBCELLULAR LOCATION: [Isoform VP3]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane.
Protein: HIS1_SHEPW
Sequence: MSESNRLRIAIQKSGRLSKESLKLLKSCGVKFNINEQRLIAHSDNMPIDLLRVRDDDIPGLVMDGVVDLGFIGENVLEEEQIERQSLNKPSECIKLRELDFGACRLSLAVPNEFNYQDASSLEGVRIATSYPNILRRYMQQKGISYNDCMLKGSVEVAPRAGLSDAICDLVSTGATLEANGLYETEVIYQSTACLIQSTTSQPDDKQALINKILSRINGVVRAKESKYILLHAPTETLEQIVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTQLGASSILVMPIEKMMG
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMP1_YEAST
Sequence: MTVGTLPIWSKTFSYAIRSLCFLHIIHMYAYEFTETRGESMLPTLSATNDYVHVLKNFQNGRGIKMGDCIVALKPTDPNHRICKRVTGMPGDLVLVDPSTIVNYVGDVLVDEERFGTYIKVPEGHVWVTGDNLSHSLDSRTYNALPMGLIMGKIVAANNFDKPFWDGSIRNIWGFKWINNTFLDVQAKSN
What is the function of this protein?
Catalytic component of the mitochondrial inner membrane peptidase (IMP) complex.  IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.  The two catalytic IMP subunits seem to have non-overlapping substrate specificities.  IMP1 substrates include nuclear encoded CYB2, mitochondrially encoded COX2, NADH-cytochrome b5 reductase and GUT2.
What are the official names of this protein?
Mitochondrial inner membrane protease subunit 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26 family. IMP1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.
Protein: COPRS_MOUSE
Sequence: MDPQAATGRGPGERSSQEAPSAEAGFATADLSGRETETELAVDRLASGAQSIPADIPAHAEGPSSEEEGFAVEKEADGELYAWELSEGPSCPPMEQAADLFNEDWDLELKADQGNPYDADDIQGSISQEIKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED
What is the function of this protein?
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5.  Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5.  Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5.  Involved in CCNE1 promoter repression (By similarity).  Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation.
What are the official names of this protein?
Coordinator of PRMT5 and differentiation stimulator, Cooperator of PRMT5.
What are the subcellular locations of this protein?
Nucleus.