PharMolix/UniProtQA huggingface dataset:
Protein: CHX6A_ARATH
Sequence: MATEEIDMSYWDVSWGEFNEDKNSSIFCESHPHIVNSHGIWEVMTFKRGMNFWEYPLPNLEILIFSTFFIWRLLDISFNKIGLRVPRFTYMMIAGIILGQTCHFSNKSWIHDIFFPDDNRPKVAETLGAFGFVLYWFLKGVTMDAELPFRTEKRSSVIGFITVIIPLICGSLTFRYRERRGDSSILRMEYRLIIFLQSISAFTSIDTLLKDLQIKHSEFGRIALSGAMVTDMLAFGVTFFNAIYYEKLYGFMQTVGFCLFVVVMICVVRPAMYWVIKQTPEGRPVKDFYLYSIFGIAFACFTFFNKVIHLFGPAGSFVFGLTVPNGYPLGTTLIQKFESFNLGSILPLFGSLTMMQVDLLRLFKESGDLIRMEGQIYEVISFILLVNTTKFVVTTITAYAFKMPLRDSFALALVLSNKGIFELAYYTYAVELKLIRPEVFTILAAYTLLNSIFIPMLLELVHDPTKRFRCYRKRNLGILKDGAALQCLMCVYRPDHITSMTDLLETFSPSQDSPMACNILHLVELVGQANPMFISHQLQKPEPGSTSLSDNVIISFRGFQRQFFEYTSLDIFTSVSVSQHMHEDICWLALSRSLSLIVLPFHRTWSVDRSTVISNDDNLRMLNVNVLRRAPCSVGIFVYRKPIVESHMAKSHSKICLIFNGGKDDREALAITNRMRLTEKRTRLTIIRFIPKSSEMDNDEWEQQQSINLKESVTSIVGSNIKENDAKVTYIDKAVSDGSETSRILRAMANDYDLFIVGSGSGIGTEATSGISEWTEFNELGPIGDLLASHEYPSSASVLVVQKQVYIHHTKSQRRKSF
What is the function of this protein?
May operate as a cation/H(+) antiporter.
What are the official names of this protein?
Cation/H(+) antiporter 6A, Protein CATION/H+ EXCHANGER 6a, AtCHX6a.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SERB_STRCO
Sequence: MSASQTSDVPTLLVKIFGKDRPGITAGLFDTLAAYSVDVVDIEQVVTRGRIVLCALVTEPPRGLEGDLRATVHSWAESLKLQAEIISGIGDNRPRGFGRSLVTVLGHPLTAEATAAIAARITESGSNIDRIFRLAKYPVTAVEFAVSGVETEPLRTALATEAAALGVDIAVVAAGLHRRAQRLVVMDVDSTLIQDEVIELFAAHAGCEDEVAEVTAAAMRGELDFEQSLHARVALLAGLDASVVDKVRAEVRLTPGARTLIRTLKRLGYQVGVVSGGFTQVTDALQEQLGLDFAQANTLEIVDGRLTGRVTGEIVDRAGKARLLRRFAAAAGVPLSQTVAIGDGANDLDMLNAAGLGVAFNAKPVVREAAHTAVNVPFLDTVLYLLGITREEVEAADTLADDLGDGPGRP
What is the function of this protein?
Catalyzes the dephosphorylation of phosphoserine (P-Ser) in vitro.  Also catalyzes the dephosphorylation of phosphothreonine (P-Thr) in vitro.
What are the official names of this protein?
Phosphoserine phosphatase, PSP, PSPase, O-phosphoserine phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. SerB family.
Protein: ATP6_HELPH
Sequence: MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFLISLGASRKMQMVPMGLQNVYESIISAILSVAKDIIGEELARKYFPLAGTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYYHFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRIVSLSFRLFGNIKGDDMFLLIMLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACCA_TOLAT
Sequence: MNMNFLEFEQPIAELLAQIEELKHVSEHVGSSVDLTDEIKHLEKKNEELTRKLFSDLGAWQISQLARHPQRPYTEDYIARMFTDFDEMAGDRAFADDKAIVGGTARLDGQPVMVIGHQKGRDTQEKIRRNFGMPRPEGYRKALRLMQMAERFKMPILTFIDTPGAYPGVGAEERGQSEAIARNLKVMSSLKVPVICTVIGEGGSGGALAIGVGDRVNMLQYSTYSVISPEGCASILWKSADKANVAAEAMGITAARLKELKLIDSIVPEPLGGAHRNVDEMANLLKQRILTDLNELNSLHTDELLRKRYQQLMSHGYC
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TERS_BPSPP
Sequence: MGEVKGKWTPKLERFVDEYFINGMNATKAAIAAGYSKKSASTIAAENMQKPHVRARIEERLAQMDKKRIMQAEEVLEHLTRIALGQEKEQVLMGIGKGAETKTHVEVSAKDRIKALELLGKAHAVFTDKQKVETNQVIIVDDSGDAE
What is the function of this protein?
The terminase small subunit specifically recognizes the non-adjacent pacL and pacR packaging subsites and regulates the ATPase activity of the terminase large subunit.  The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities.  Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine.  The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer once the capsid is full (headful packaging).  Once the capsid is packaged with the DNA, the terminase complex is substituted by neck proteins.
What are the official names of this protein?
Terminase small subunit, G1P, Terminase, small subunit gp1.
What is the protein family that this protein belongs to?
Belongs to the SPP1-like small terminase family.
Protein: SAHH_PROMP
Sequence: MVIANSIKTSIPNYVIKDISLSDFGRKEIKIAETEMPGLMALRDKHHSDKPLNGAKIAGSLHMTIQTAVLIETLVDLGAQVKWASCNIFSTQDHAAAAIAEQGISVYAKKGESLDEYWQYTHYILDWGTDSPNMILDDGGDATGLLILGSKAEKDLSVLKNPSNEEEIALFNSIRSKLQEDSSFYSRIKGNIIGVTEETTTGVARLYQLQKQNALPFPAINVNDSVTKSKFDNLYGCRESLVDSIKRATDVMIAGKVALVMGFGDVGKGSAQSLRGLGAIVKVAEVDPICALQAAMEGFSVVTLNDVVEDIDIFVTATGNYQVITNDNLIKMKDEAIVCNIGHFDNEIDVASLKDYPWENIKPQVDHITLPSGNKIILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQIELFNKSDEYSKEVYVLPKHLDEMVARLHLDKIGAKLTKLTKDQADYINVSVEGPYKPEQYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTHD3_HUMAN
Sequence: MPWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLEGLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKAERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLRVAREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGFFGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILALKKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREVVCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQDPNEKNTFMNNIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSSAKKKILLFQLRRIAEDCQIPLMVYNQAFIYFDQYAAILEDTVRNVLVASAAMFIVSLLLIPYPLCSLWVTFAIGSVIVGVTGFMAFWKVNLDSISMINLVICIGFSFDFSVHISYAFVSSSQPSVNQKSVEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMIFGAAHGLIFIPVFLTFFGRFI
What is the function of this protein?
May play a role in sperm development or sperm function (PubMed:17904097).  However, does not appear to have an essential role in spermatogenesis or male fertility (PubMed:21439084).
What are the official names of this protein?
Patched domain-containing protein 3, Patched-related protein.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to the midpiece of the sperm tail.
Protein: Y107_OSHVF
Sequence: MFKITGVVSFIDDDPNAKVKLNSEGRFMEIPLKMAQRFLNNNNDRIKGKKKKIPILFNHFNNLPQLGTVDNLEIIERGVNDNDGLGNKKRKVLQMTATLSNRSFIKALQESSHFYNTTDKHMEYYSPDGFLSGGNSNPSGEMVTGRSAIMKRFPGLSIGHLDNDGYDIEEISLCYAGARPGTILTDASYSDHCGLAEDDTGSNSTAFLKAWAAKPFAMMTSRAGKIAEDINMLGVKNESLVYGLENKEDDVNDKPLPPQQPIDQPIDVEVMKSSLPENNKEDISTTKDTTPNEVEEHNINTIENEISSPFTQKSPDELDTETMSRIQDEVKALAAESASLRDDIKKYIAEALVQKDSGSSSVRRDRSPVDRRDRDRTPPRRERRRRDYDDYDSEDDYEDRRPTKKLFRRSRDEGEFLHSRKNKREHSRNRFDEFEDSRFDEEDRDMYRRRPTPQQSFYEAQSLPRRLLKRQVIQDDFDEEDYYQVRKPAKRQRVIFEDDLDEFYQPPVQQRRLAPRAPVYQEPQYDDYVVVPRQKQQQHVLPAASQRRVVRPQQLRPQFHDQDVEYVTIDPQTGMEVEYEPVAPAPKKRVVKVAQPVQRQVVKQTQPRAPEPVEMEEGEIEEEEEVVEEQLAPVKKMPVPKAVPVKRAEAVDAQPTPPQAAAPTQEYSFKKPTGKTTEAHFDELMDQMF
What is the function of this protein?
May act as an apoptosis inhibitor.
What are the official names of this protein?
Uncharacterized protein ORF107.
Protein: RL22_STRGG
Sequence: MEARAQARYIRVTPMKARRVVDLIRGMDATEAQAVLRFAPQAASVPVGKVLDSAIANAAHNYDHTDASSLVISEAYVDEGPTLKRFRPRAQGRAYRIRKRTSHITVVVSSKEGTR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: GCSH_KOCRD
Sequence: MTNIPAELAYTAEHEWVQDLSEDSTFKVGITDHAQSELGEVVFVQLPEVGDTVTAGDVVGEIESTKSVSDLFAPVTGEIVSVNDELADNPGLLNEAPYEAGWLFTVRVESQDATAQLLDAQAYQQLLD
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: IF2_XANCB
Sequence: MLWARGRQPDHRIRMSQQTTIRKLAELVNTPVDKLLVQLAEAGMKFSGPDQVVTSTEKMKLLGFLRRTHGKADTPAEAASEAAKKITLNRRKLQEVTVNAGRTKTTVNVEVRQKRTYVKSDNEGSGRAAPMTPDEERADILAKLAASRQRNLDEQQRLAESDRARDEAIQRKRDEEQAAKDRVEAERKAAEEAAAAASAPAPVAAAPAPSSAPAARAPSSPSSAPRPARPAGASPASRPATPARPDDRNNAAKHKTRGSHVMVAGVEDDDATKRFAGQLHLSAADRARRSNVRGKPTGRPGSSSSRRNDGGRGSNQSNSGPHGFERPTAPVVREVAIGETITVADLAQKLALKGGDVVKALFKMGVMATITQSIDHDTAALVTEELGHKAVRADNADFEDALLAHAEDAQGETTSRPPVVTIMGHVDHGKTSLLDYIRRTKIASGEAGGITQHIGAYHVETGRGVISFLDTPGHAAFTSMRARGAKITDIVVLVVAADDGVMPQTKEAVAHAKAAGVPLIVAVNKIDKAGADPLRVKNELLAENVVAEDFGGDTQFIEVSAKVGTGVDTLLDAISLQAEVLELKAVADGRASGTVIESSLDKGRGPVATVLVQQGALKRGDYLVCGIQYGRVRALFDETGHQPASAGPSIPVQVLGLSGVPEAGDDFVVVDDERLAKDVAQQRETKRRESRLVASATNRMEDILAQMGKGEGQQVLNLVIKADVQGSVEALKQSLVALSNDDIRINVIHSGVGGITESDANSAAASKATIIGFNVRADASARKIVESNGIDLRYFSIIYDVIDQVKQVASGLLGVEIREEIIGIAQVRDVFRSSKFGAVAGCMIIEGVVKRSKPIRVLRDSVVVFEGELESLRRFKENVDEVRNGTECGIGVKAYNDVKAGDQIECFERIEVARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM11L_RAT
Sequence: MTVSKLRPVIASRKSFPPWMIILGVLGVLAILGLIIGLLVHFLAVENKIYYYQGSFKVLNIPYDRNYERETSLESNYLSKILEIKMVDAFESSNIYKQYINSQIITLVPENNSVTAHIWLVFKDPWSNKENLRRRIESILHQMLENNSGSLTTDPGSLKLTEITKVDAEKIINNRCGRRPRMSATYDRITGGSTAQKGEWPWQASLRVNGKHHCGASLIGERFLLTAAHCFLRTNNPKNLTVSFGTRVTPAYMQHYVEEVIIHEDYVKGQHHDDVAIIKLTEKVSFRNDVHRVCLPEATQVFPPGEGVVVTGWGSLSYNGKSPLLLQKASIKIIDTNACNSEEAYGGRIMDTMLCAGYMEGYVDACQGDSGGPLVHPNSRDIWYLVGIVSWGHECGRVNKPGVYMRVTSYRDWIASKTGI
What is the function of this protein?
Serine protease.
What are the official names of this protein?
Transmembrane protease serine 11B-like protein, Airway trypsin-like protease 5, Transmembrane protease serine 11B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein. Cell membrane.
Protein: REX_STRPI
Sequence: MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLHYRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSVKSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCD_PSEPG
Sequence: MSNWLVDKLIPSIMRSEVKKSSVPEGLWHKCPSCEAVLYRPELEKTLDVCPKCNHHMRIGARARIDIFLDAEGRAELGADLEPVDRLKFRDGKKYKDRLTGAQKQTGEKDALISMSGTLMGMPIVVSAFEFSFMGGSMGAIVGERFVRAANYALEHRCPMVCFSASGGARMQEALISLMQMAKTSAVLARLREEGIPFISVLTDPVYGGVSASLAMLGDVIVGEPKALIGFAGPRVIEQTVREKLPEGFQRSEFLLEHGAIDLIISRGELRPRLARLLAQMTGQDTPEQAREAAAVA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBB_YERP3
Sequence: MNQTLLSDFGTPVERVERAIDALRNGRGVMVLDDESRENEGDMVFAAEAMTLEQMALTIRHGSGIVCLCITDERRQQLDLPMMVTHNSSQFQTAFTVTIEAAEGVTTGVSAADRLTTIRKAIADNAKPADLNRPGHVFPLRGQPGGVLSRRGHTEASIDLATLAGYKPAGVLCELTNDDGSMAHAPEVIAFAKLHDMPVVTIDDLAAYLQSRAKKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: VATL1_CAEEL
Sequence: MSTDTKQIIADALLKNEQAMYGPFFGSLGVTSAMAFAAAGSAYGTAKAGTGIASMAVARPDLVMKAIIPVVMAGIVAIYGLVVAVIVSGKVEPAGANYTINNAFSQFAGGLVCGLCGLGAGYAIGIAGDAGVRALSQQPRMFVGMILILIFAEVLGLYGMIVALILGAT
What is the function of this protein?
Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad (PubMed:29168500).  This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization (PubMed:29168500).  The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates (PubMed:29168500).  Lysosomal acidification also leads to changes in mitochondrial morphology and function (PubMed:29168500).  Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity (PubMed:29168500).  In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance (PubMed:29168500).  Plays a role in the processing and secretion of the aspartic protease hrg-7 from the intestine (PubMed:28581477).  During embryonic development, the V-ATPase is required to repress fusion of epidermal cells probably by negatively regulating eff-1-mediated cell fusion (PubMed:15866168).  Involved in receptor-mediated endocytosis (PubMed:16785323).
What are the official names of this protein?
V-type proton ATPase 16 kDa proteolipid subunit c 1, V-ATPase 16 kDa proteolipid subunit c 1, Vacuolar proton pump 16 kDa proteolipid subunit c 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase proteolipid subunit family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ENY2_DROMO
Sequence: MTVSNTVDQYTIMSGDRSKIKDLLCNRLTECGWRDEVRLLCRNILVEKNGNNSLSVEQLIAEVTPKARTLVPDAVKKELLMKIRTILAENEGDN
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes.  The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Involved in transcription elongation by recruiting the THO complex onto nascent mRNA.  The AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
What are the official names of this protein?
Enhancer of yellow 2 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm.
Protein: RL20_HISS2
Sequence: MARVKRGVIARARHKKVLKAAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAATRQNGLSYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKSAL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: AACUO_ASPA1
Sequence: MTAPASTQAATLKRFISAWEKWDAQEWISTFSDDFQQVTLPHSLSVPVRTRKEVEIVLPALVATVKSYQLQIHHVIHDPDNNKAVVYAASTGKLPWGDWNLEYAAFLTFTDDGGKVARLEEMLDTAFLQDFGPKFGKYLEENGGPVAVAAGGKQDLRSEA
What is the function of this protein?
Monooxygenase; part of the gene cluster that mediates the biosynthesis of the tetrahydroxanthone dimer secalonic acid D (PubMed:30996871, PubMed:33891392).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase AacuL (Probable).  The atrochrysone carboxyl ACP thioesterase AacuM then breaks the thioester bond and releases the atrochrysone carboxylic acid from AacuL (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase AacuI, and oxidized by the anthrone oxygenase AacuG to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by a yet unidentified oxidoreductase (Probable).  A-ring reduction by the short chain dehydrogenase AacuN, dehydration by the scytalone dehydratase-like protein AacuK and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:33891392).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) AacuH then yields monodictyphenone (PubMed:33891392).  Monodictyphenone is transformed into compounds with the tetrahydroxanthone skeleton via methylesterification by the methyltransferase AacuQ, followed by the action of the flavin-dependent monooxygenase AacuC, the isomerase AacuP, and the short chain dehydrogenase/reductase AacuF or AacuD (PubMed:33891392).  AacuF and AacuD should accept the same compound as a substrate but perform the ketoreduction with a different stereoselectivity, thus yielding blennolides B and A, respectively (PubMed:33891392).  In the final step of the biosynthesis, the cytochrome P450 monooxygenase AacuE accepts blennolide B and/or blennolide A to conduct the dimerization reaction to furnish the tetrahydroxanthone dimers, secalonic acids D, B, and F (PubMed:33891392).
What are the official names of this protein?
Monooxygenase AacuO, Secalonic acid biosynthesis cluster protein O.
What is the protein family that this protein belongs to?
Belongs to the avfA family.
Protein: RRFM_HUMAN
Sequence: MALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKAKGKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAKDSLRKVRTNSMNKLKKSKDTVSEDTIRLIEKQISQMADDTVAELDRHLAVKTKELLG
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).
What are the official names of this protein?
Ribosome-recycling factor, mitochondrial, RRF, Ribosome-releasing factor, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GBG11_HUMAN
Sequence: MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSGEDPLVKGIPEDKNPFKEKGSCVIS
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.  The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
What are the official names of this protein?
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11.
What is the protein family that this protein belongs to?
Belongs to the G protein gamma family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: MED27_PIG
Sequence: MADVLSVGVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 27, Cofactor required for Sp1 transcriptional activation subunit 8, CRSP complex subunit 8, Mediator complex subunit 27.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 27 family.
What are the subcellular locations of this protein?
Nucleus.