PharMolix/UniProtQA huggingface dataset:
Protein: LMOD1_MOUSE
Sequence: MSKVAKYRRQVSEDPDIDSLLSTLSPEEMEELEKELDVVDPDGSIPVGLRQRNQTDKQPSGSFNREAMLNFCEKESKKLIQREMSVDESKQVGRKTDAKNGEEKDSDASRKAPGPRQDSDLGKEPKKGVLKKSFSRDREEADGRGGEKPKEEKVIRGIDKGRVRAAVDRKESGKDGREERAAAARKEEEKTGSVKNAGLSRDKDKKKEEVKEPSKKEEVKLTAESRNTVGRREDGRLKESSKENKKPEDEGIGSGGRDWRKEDEKVKKEENQPDKEVREESKTKAPEKQAPSCPNKPSDGQARAEEEAAPSIFDEPLEKVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTVVKVFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHICGVKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQEQKQAQEASGEKKDRLEVPKVGALAKGSPKPSPQPSPKPAPKNSPKKAGVPAAPPPPPPPLAPPLIMENLKNSLSPATQRKMGDKVLPAQEKNSRDQLLAAIRSSNLKQLKKVEVPKLLQ
What is the function of this protein?
Required for proper contractility of visceral smooth muscle cells (PubMed:28292896).  Mediates nucleation of actin filaments (By similarity).
What are the official names of this protein?
Leiomodin-1.
What is the protein family that this protein belongs to?
Belongs to the tropomodulin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Note=Colocalizes with actin filaments in sarcomeres.
Protein: NTF2_CAEEL
Sequence: MSFNPDYESVAKAFIQHYYSKFDVGDGMSRAQGLSDLYDPENSYMTFEGQQAKGRDGILQKFTTLGFTKIQRAITVIDSQPLYDGSIQVMVLGQLKTDEDPINPFSQVFILRPNNQGSYFIGNEIFRLDLHNN
What is the function of this protein?
Facilitates protein transport into the nucleus.  Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).
What are the official names of this protein?
Probable nuclear transport factor 2, NTF-2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP2_CHRVO
Sequence: MQDHNKKAMAGLTLAALGVVYGDIGTSPLYTLRECFVSQNLPTTPDNIFGILSLIFWSLIFVVSVKYVAFVLRADNRGEGGIMALMALARHYTTHAARWKIVLLGLFGAALFYGDAIITPAVSVLSAAEGMEVVSSGMEAYVLPMAVGVLVGLFLLQRHGTARVGLMFGPVMMVWFAILGILGLHQIIQQPAVLQALNPWHAVTFLSQHGFHAFLTLGSVVLALTGAEALYADMGHFGKTPIRRAWFSLVLPGLGLNYFGQGALLMSNPAAIKNPFFLLAPDWALLPMIALATLATVIASQAVISGAYSLTRQAILLGYCPRLEVHHTSDKEIGQIYMPFINWALLVAVLVVVLTFKNSSSLAAAYGIAVTGTMLITTMLFFVVARVNWRWPLPLALGITLLFGVIDTAFFAANVHKVADGGWLPLVMGMAIFTLMSTWKQGRDILFKRLREQALPLDDFIHNLEAYPPARVEGTAVFLTSTLHGVPHALLHNLKHNKVLHERVVLMTVRTEDIPYVPEDERLEIVQMSASFWRVMARYGFKEEPNVVEVLDKCAKEGFEMELMDTSFFLSRETIVSTGHPGMARWRQKIFLWMSKNALRATDFFQVPTNRVVELGAQVEL
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 2.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS1_DESAP
Sequence: MKLRLGLPKGSLQEKTFQLFKKAGYDLQVNSRSYYPAVNDPELEILLMRAQEIPRYVHEGVLDAGLSGLDWIMENEADVVEVADLIYSKRSQRPVRLVLAVANDSDIREVRDLQGKRIATELVNVTRRYLAAQGVEAIVEYSYGATEVKVPNLVDAIADLTETGSSLRANNLRILAVILESNTKLHANRAAWADPWKREKLLNLTVLLTGALRAENMVGLKMNVPGDRIDAVLGVLPAMKHPTVSQLFNSDWVAIETILNEQQVRDLIPILKRAGAQDIIEYPLNKVIP
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDKD1_ORYSI
Sequence: MASGDGGDDAGVKRVADRYLKREVLGEGTYGVVFKADDTKTGNTVAIKKIRLGKYKEGVNFTALREIKLLKELKDSNIIELIDAFPYKGNLHLVFEFMETDLEAVIRDRNIVLSPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLIGADGQLKLADFGLARIFGSPERNFTHQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFAAFGTPKSSQWPDMVYLPDYVEYQFVSAPPLRSLFPMASDDALDLLSRMFTYDPKARITAQQALEHRYFLSVPAPTKPSQLPRPPPKGDSGNNKIPDLNLQDGPVVLSPPRKLRRVTAHEGMEVHMHRADRTEEHPSGARHMDDMSSQSSRIPMSVDVGAIFGTRPAPRPTLNSADKSRLKRKLDMDPEFGYTE
What are the official names of this protein?
Cyclin-dependent kinase D-1, CDKD;1, CDC2+/CDC28-related protein kinase R2, CDK-activating kinase R2, CAK-R2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CDSN_MOUSE
Sequence: MGSSRAPRMGSVGGHGLMALLMAGLILPGILAKSIGTLSDPCKDPTRITSPNDPCLIGKTGSNSISSQGGSSSFSSQGGSSSFSSHGGSSSSQGSSSGSLIYKPGTGYSQSSYSYGSGGSRPGGSGSQSGSSGSQSGSSGSQSGSSGSQSGSSGSQSGSSGSQSGSSGSQSGSSGSQSGSSGSQSGRWVSSSSQWVSSSSQSGSSGSSRDRPGSGSALPTGDKTSGMSQSGGSSTSQSSSSNLRPCSSNVPDSPCSGGPVITHSGPYISGTHTVSGGQRPVVVVVEQHGSGGPGFQGMPCSNGGPAGKPCPPITSVQKPYGGYEVVGGSANSYLVPGMTYSGGKIYPVGYFTKDNPIRGSPGAPSFAAGPPVSEGKYFSSNPIIPSRGSSSSSGYPVGVAFQPVGSGGVQPCGTGSVSSKGPCSGTRIQITSSSSSTSYHPCSGGPSQGPCSSPGTGSISGGSSSLSSGKIVLQPCGSKSTSSGYPCLSVPSSPLNGGLNGSPQPVPSVGVKLCGLNSPGRVPCRSIRNILTQVKPLGPQLMDPKVSLPQGEPQGEPLEKS
What is the function of this protein?
Important for the epidermal barrier integrity.
What are the official names of this protein?
Corneodesmosin.
What are the subcellular locations of this protein?
Secreted. Note=Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
Protein: GLGC_PECCP
Sequence: MVNNDKHDPLMLARQLPLKSVALILAGGRGTRLKGLTALRAKPAVHFGGKFRIIDFALSNCLNSGIRRIGVITQYQSHTLVQHIQRGWSFLNAEMNEFVDLLPAQQRNATDHWYRGTADAVCQNLDIIRRYRAEYVVILAGDHIYKMDYSRMLIDHVEKGAECTVACLPVPLEEASAFGVMSVDKQHRILDFAEKPDNPTPMPDNPDMALASMGIYVFNADYLYQLLDADHNTPDSNHDFGQDLIPKIVSQRLAWAHPFTLSCVTSGEDENQYWRDVGTLEAYWRANLDLASVTPELDVYDRHWPIRSAIESLPPAKFVQDRSGSHGMTMNSLVSGGCIVSGSVVTHSVLFPRVRVNSFCSIDSTVILPDVNVGRSCRLRRCVIDRACNLPEGMVIGENAEEDSRRFYRSEEGIVLVTRSMLEKL
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: ISPD_VIBCH
Sequence: MNNMTAIVPAAGVGSRMQADRPKQYLTLLDKTVLEHTVEHLLEHPLIEHVVVAVSADDPYFANLPLAHHPRVIRVDGGKERADSVLSALEYVCQHRLSEWVLVHDAARPCVTHADITQLITTALAHPIGAILASPVRDTMKRGDHLQQIVHTVDRTALWHALTPQMFRAQSLRERLFAALQQQVTITDEASAFEWRGEKPALVAGRADNLKITQPEDLALAEFYLSRNKEKS
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: MOGS_RAT
Sequence: MARGERRRRAAAAEGARPLERARGAGRRDGRAGGARGSAGGAALAVVVLALAFGLSGRWVLAWLGVRRALTLHPAPSALPPDSSSPAVAPEFFWGTYRPHVYFGMKTRSPKPLLTGLMWAQQGATPGTPPKLRHTCEQGDGVGPYGWEFHDGLSFGRQHIYDGALRLTTEFVKRSGGHHGGDWSWRVTVEPQASGTPSFPLVSLFFYVVTDGQEVLLPEVGAKGQLKFISGHTSELGDFRLTLLPPTTPGDTVPKHGSYNVFWSSNPGLPLLTDMVKSHLNSWFHHRPPGASPERYLGLPGSLKWEERGPSGQGQFLVQQVTLKAPFSVEFVFESGSARTGRDQASEQLVGGQLTRALESHAAAFKERFERTFQLKEKGLSPEEQALGQVALSGLLGGIGYFYGQGLVLPDTGMEGSEQKMDPSLFPPVPLFSGVPSRSFFPRGFLWDEGFHQLVVQRWDPHLTREALGHWLGLLNADGWIGREQILGDEARARVPPEFLVQRAAHANPPTLLLPVIHMLEGRAPEDLAFLRRAFPRLHAWFSWLHQSQAGPVPLSYRWRGRDLALPTLLNPKTLPSGLDDYPRASHPSAAERHLDLRCWVTLGARVLSQLAEELGETEAAAELGPLAASLEAAGSLDELHWAPELGVFADFGNHTKAVQLKSRPPQGLVRVVGRPPARLQYVDALGYVSLFPLLLQLLEPSSPRLGPLLDVLADSRHLWSPFGLRSLSASSLFYKQRNTEHDPPYWRGAVWLNINYLALGALHHYGRVEGPHKVQAAKLYRELRANVVSNVRQQYQATGFLWEQYSDQDGRGMGCRPFQGWTSLVLLIMAEEY
What is the function of this protein?
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.
What are the official names of this protein?
Mannosyl-oligosaccharide glucosidase, Glycoprotein-processing glucosidase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 63 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: YIDD_ANOFW
Sequence: MKHIFILLIRFYQRFISPLKPPTCRFYPTCSHYGLEAIRRFGALKGGYLTIKRILKCHPFHPGGFDPVPEKEQK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AOFA_HORSE
Sequence: MASQEKASMAGHMFDVVVIGGGISGLSAAKLLAEHETNVLVLEARDRVGGRTYTVRNKHVNYVDVGGAYVGPTQNRILRLSKELGLETYKVNVNERLVQYVKGKSYPFRGAFPPVWNPIAYLDYNNLWRTMDNMGKEIPADAPWEAPHAEEWDKMTMKDLIDKICWTKTARQFASLFVNINVTSEPHQVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMELLGDRVKLEHPVTYVDQSGDNIIVETLNHEHFECKYVISAIPPALTAKIHFKPELPSERNQLIQRLPMGAIIKCMMYYKEAFWKKKDYCGSMIIEDEEAPISITLDDSKPDGSLPAIMGFILARKADRLAKLHKEMRKKKICELYAKVLGSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATRWSGYMEGAVEAGERAAREILNALGKVAEKDIWLQEPESKDVPAVEITHSFWERNLPSVGGLLKIIGFSTSITALWIVVYKFKLLTRS
What is the function of this protein?
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.  Preferentially oxidizes serotonin.  Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
What are the official names of this protein?
Amine oxidase [flavin-containing] A, Monoamine oxidase type A, MAO-A.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Protein: MLTF_SHESW
Sequence: MTRFLLIIILGFLLTACQQVTVDEPEFVPHQLTELRVGTLYGPQIYMTSGQGNSGFDYDMALRFAEYLNVPLKMVPYTNRSELYDALKKNDIDIIAAGMTETPARREQFRLGPPLYRVNQVLVYREGVAAPKDISKLKGRITIIADSAFVETLTQLQKHHPSLVWDQVTDKDSEELLAMIANKEIDYTIADSSSVQINRRYLPDLRSGPVLEEKLDVVWLLPPTHSDALMSQLLAFWHQEKLAGTLDHLNEKYFGHVKRFDYIDTRAFLRAIETVLPRYRQLFETHAGDLDWRKLAATSYQESHWNPHARSPTGVRGMMMLTEPTAKEIGITNRLDAEESIRGGAAYLRDMINRLPESIPESQRMWFALASYNIGYAHVEDARKLAESMELNPNAWRDLKKVLPLLQKRKYYQKTRYGYARGSEAVHYVDSIRRYYDTLVWVDNQSKQPMPEDEQNDLIAEELPSMPAGSLSPDQPK
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: TRBC_RHIRD
Sequence: MSLKTHHTPIFTALALVALGSLDGALASSGGGSLPWESPLQQIQQSITGPVAGFIALAAVAIAGAMLIFGGELNDFARRLCYVALVGGVLLGATQIVALFGATGASIGELHSQVDPFGYSPSPKLIERGEGAHG
What are the official names of this protein?
Conjugal transfer protein TrbC.
What is the protein family that this protein belongs to?
Belongs to the TrbC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CYO11_VIOOD
Sequence: MEMKNMVVGLFLIAAFALPALATSFEKDFITHETVQAILKKVGPSSNGMLDEQAISALTGKTIISNPVLEEALLTHSNSINALGGTLPCGESCVWIPCISAVVGCSCKSKVCYKNSLA
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cycloviolacin-O11, Cyclotide c2.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: RBFA_PSEU2
Sequence: MAKEYSRTQRIGDQMQRELAQLIRREIKDPRVGLVTITAVDVSRDVGHAKIFMTVMGQDSAEEIAQTIKVLNSAAGFLRMQLAREMKLRSVPQLHFHYDESVVRGAHLSALIERAVAEDGQHQEGPASADAKPESTEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCDH_MOUSE
Sequence: MSLRGVSARLLSRRSGLRFPRFPRTWSSAAAHTEKTQIRPAKSSRPVFDWKDPLILEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFHRDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHPIYTYGSEEQRQKYLPGLAKGELLGCFGLTEPNHGSDPGGMETRARHNPSNQSYTLSGTKTWITNSPVADLFIVWARCEDNCIRGFILEKGMRGLSAPRIEGKFSLRASATGMIIMDSVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVPLARNQLVQKKLADMLTEITLGLHACLQLGRLKDQDKATPEMVSMLKRNNCGKALDIARQARDILGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTVGK
What is the function of this protein?
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism.  It uses electron transfer flavoprotein as its electron acceptor.
What are the official names of this protein?
Glutaryl-CoA dehydrogenase, mitochondrial, GCD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: Y112_ENCCU
Sequence: MSEEHHYKVHSRVLRWMKSAERIKRELDEGYEKKWRGKSVEEIKEQKKVHDIVEILELLKSKECDRFFFRTGKYMKGGSERWKMVANGILEEGGEKKVGKVEVGLFKGERGGSVVYHLMFRPTETERAGMVGGSSFGKGDDVDEIKKEESSDMSGFRYPPGVRCEMTSNGNEFRIEYRNPKNTSEVLRTLTILRIPEIR
What are the official names of this protein?
UPF0329 protein ECU01_0120/ECU01_1490/ECU08_0050.
What is the protein family that this protein belongs to?
Belongs to the UPF0329 family.
Protein: HIS6_PROMH
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAERYAKEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIRSVEDAGKILSFGADKISINSPALSDPTLISRLADRYGVQCVVVGIDTWFDEKTGEYLVYQFTGDEKRTQQTPWKTLDWVQEVQQRGAGEIVLNMMNQDGVRQGYDLKQLALVRQVTQVPMIASGGAGEMSHFLDAFKLANVDGALAASVFHKQIININELKQYLAENGVKVRI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAO1_PSYIN
Sequence: MTFQRPLYIPFAGPALLESPLLNKGSAFSQEERNNFNLTGLLPHNIETIESQSTRAYQQLSSFKSDLDKHIYLRNIQDTNETLFHHLIENHLEEVMPLIYTPTVGLACEQFSKIYRRKRGLFVSYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACGGISPAYCLPIVLDVGTNNSQLLADPMYMGWRNPRITGEEYNEFVDLFIQAVKRRWPEVLLQFEDFAQTNATPLLNKYRDQICCFNDDIQGTAAVSVGTLIAACQNKGEKLSDQRIAFLGSGSAGCGIAQHIVRQMQREGLTQEQARQRVFMVDRYGLLTDQMTNLQAFQQPLIQYTKDLSHWDISSHIGLEQVIKQGNISVLFGVSGQPGLFTQEVVESLCANVDHPIVLPLSNPTSRVEATPKDITTWSHGQAIVATGSPFPPTLYENEYIEVSQCNNSYIFPGIGLGVLAARATAISDNMLMAASQALADASMQYEKVKGALLPPLGEIRPISKSIAYAVAKQAIADGLALPVSEETMQRRLVDNFWAPKYRTYRRTSF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: TRUB_RICCK
Sequence: MSNYWLNIYKPRGISSAKLVSIVKTILGKVKIGHAGTLDVEAEGVLPLAVGEATKLVQILIDAKKSYIFTVQFGKQTDSGDYAGKVIATKDYIPYKEEAYAVCSKFIGNITQIPPVFSALKVNGVRTYKLARVGTAVELKPRNITIYDLKCLNFDEKNATATYYTECSKGTYIRTLAEDLALSLQSLGFVIELRRTQVGIFKEKNAIRIKSSDAIIKNSLEEKSIKIEAILDDILVLDATDQQAQQIKYGQKCLFNYEKDINLLWVRYKGVVLAIGSLNKSCFNSLRVLNLTQ
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: N4BP3_MOUSE
Sequence: MATTSGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQREFFSYLHLPKKDGKTTKRAPRNEPDYATLYYREHPRAGDFSKTSLPERGRFDKCRIRPSVFKPPVGSGKGFLSMQSLAAHKGQKLWRSNGSLHTLACHPPLSPGPRASQARAQLLHALSLDEGGPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHINHLGGSLDRAPRSPKESGPLAVLSCLPEPPPPYEFSCPTTEEVAVLPEAREELKRDLGDQDVSNSFTQVLEERQRLWLSELKRLYVERLHEVAQKAERSERNLQLQLFMAQQEQRRLRKELRAQQGLAPEPRTSGSSMEADPNARPEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELARLREAVHSLQEQAPREEAPGSCETDDCKSRGLLGEAGGSEAREGAEQLRAELLQERLRGQEQALRFEQERQTWQEEKERVLRYQREIQGSYMDMYRRNQALEHELRLLREPPTSWSPRLESSKI
What is the function of this protein?
Plays a positive role in the antiviral innate immune signaling pathway.  Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (By similarity).  Also plays a role in axon and dendrite arborization during cranial nerve development.  May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity).
What are the official names of this protein?
NEDD4-binding protein 3, N4BP3.
What is the protein family that this protein belongs to?
Belongs to the N4BP3 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Cell projection, axon. Cell projection, dendrite. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites.
Protein: PSMD6_HUMAN
Sequence: MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit RPN7, 26S proteasome regulatory subunit S10, Breast cancer-associated protein SGA-113M, Phosphonoformate immuno-associated protein 4, Proteasome regulatory particle subunit p44S10, p42A.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S10 family.
Protein: SOX14_HUMAN
Sequence: MSKPSDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDPLKAAGLPVGASDGLLSAPEKARAFLPPASAPYSLLDPAQFSSSAIQKMGEVPHTLATGALPYASTLGYQNGAFGSLSCPSQHTHTHPSPTNPGYVVPCNCTAWSASTLQPPVAYILFPGMTKTGIDPYSSAHATAM
What is the function of this protein?
Acts as a negative regulator of transcription.
What are the official names of this protein?
Transcription factor SOX-14, Protein SOX-28.
What are the subcellular locations of this protein?
Nucleus.
Protein: RLA1_LEIPE
Sequence: MTTETLACTYAALMLSDAGLPTSAENIAAAVKAAGVSVRPTMPIIFARFLEKKSVEALMAAAATQAPTATSAAAAPAAGEASGKAEEKKKEEPEEEGDDDMGFGLFD
What is the function of this protein?
Plays an important role in the elongation step of protein synthesis.
What are the official names of this protein?
60S acidic ribosomal protein P1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Protein: ANC2_HUMAN
Sequence: MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVEVLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLESRLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQFHQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIEDLKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS
What is the function of this protein?
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.  The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons.  CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
What are the official names of this protein?
Anaphase-promoting complex subunit 2, APC2, Cyclosome subunit 2.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
Protein: SYP_METTH
Sequence: MQKPIKKDPNRYHGEKMTEFSEWFHNILEEAEIIDQRYPVKGMHVWMPHGFMIRKNTLKILRRILDRDHEEVLFPLLVPEDELAKEAIHVKGFEDEVYWVTHGGLSKLQRKLALRPTSETVMYPMFALWVRSHTDLPMRFYQVVNTFRYETKHTRPLIRVREITTFKEAHTIHATASEAEEQVERAVEIYKEFFNSLGIPYLITRRPPWDKFPGSEYTVAFDTLMPDGKTLQIGTVHNLGQTFARTFEIKFETPEGDHEYVHQTCYGLSDRVIASVIAIHGDESGLCLPPDVAAHQVVIVPIIFKKAAEEVMEACRELRSRLEAAGFRVHLDDRDIRAGRKYYEWEMRGVPLRVEIGPRDLEKGAAVISRRDTGEKVTADLQGIEETLRELMKDILENLRTRAWERMESEIREAETLEEASRIVDEKRGIISFMWCGEEECGMDVEEKVRVDILGIQEEGSGTCINCGREAPTGLTLPEHIS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  Can inadvertently accommodate and process cysteine.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_MYCLE
Sequence: MKANIHPAYAETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRKVGVDQVAAYPEQNNK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.