PharMolix/UniProtQA huggingface dataset:
Protein: DPO3_STAA3
Sequence: MTEQQKFKVLADQIKISNQLDAEILNSGELTRIDVSNKNRTWEFHITLPQFLAHEDYLLFINAIEQEFKDIANVTCRFTVTNGTNQDEHAIKYFGHCIDQTALSPKVKGQLKQKKLIMSGKVLKVMVSNDIERNHFDKACNGSLIKAFRNCGFDIDKIIFETNDNDQEQNLASLEAHIQEEDEQSARLATEKLEKMKAEKAKQQDNNESAVDKCQIGKPIQIENIKPIESIIEEEFKVAIEGVIFDINLKELKSGRHIVEIKVTDYTDSLVLKMFTRKNKDDLEHFKALSVGKWVRAQGRIEEDTFIRDLVMMMSDIEEIKKATKKDKAEEKRVEFHLHTAMSQMDGIPNIGAYVKQAADWGHPAIAVTDHNVVQAFPDAHAAAEKHGIKMIYGMEGMLVDDGVPIAYKPQDVVLKDATYVVFDVETTGLSNQYDKIIELAAVKVHNGEIIDKFERFSNPHERLSETIINLTHITDDMLVDAPEIEEVLTEFKEWVGDAIFVAHNASFDMGFIDTGYERLGFGPSTNGVIDTLELSRTINTEYGKHGLNFLAKKYGVELTQHHRAIYDTEATAYIFIKMVQQMKELGVLNHNEINKKLSNEDAYKRARPSHVTLIVQNQQGLKNLFKIVSASLVKYFYRTPRIPRSLLDEYREGLLVGTACDEGELFTAVMQKDQSQVEKIAKYYDFIEIQPPALYQDLIDRELIRDTETLHEIYQRLIHAGDTAGIPVIATGNAHYLFEHDGIARKILIASQPGNPLNRSTLPEAHFRTTDEMLNEFHFLGEEKAHEIVVKNTNELADRIERVVPIKDELYTPRMEGANEEIRELSYANARKLYGEDLPQIVIDRLEKELKSIIGNGFAVIYLISQRLVKKSLDDGYLVGSRGSVGSSFVATMTEITEVNPLPPHYICPNCKTSEFFNDGSVGSGFDLPDKTCETCGAPLIKEGQDIPFETFLGFKGDKVPDIDLNFSGEYQPNAHNYTKVLFGEDKVFRAGTIGTVAEKTAFGYVKGYLNDQGIHKRGAEIDRLVKGCTGVKRTTGQHPGGIIVVPDYMDIYDFTPIQYPADDQNSAWMTTHFDFHSIHDNVLKLDILGHDDPTMIRMLQDLSGIDPKTIPVDDKEVMQIFSTPESLGVTEDEILCKTGTFGVPEFGTGFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIKTGICDLSSVIGCRDDIMVYLMYAGLEPSMAFKIMESVRKGKGLTEEMIETMKENEVPDWYLDSCLKIKYMFPKAHAAAYVLMAVRIAYFKVHHPLYYYASYFTIRASDFDLITMIKDKTSIRNTVKDMYSRYMDLGKKEKDVLTVLEIMNEMAHRGYRMQPISLEKSQAFEFIIEGDTLIPPFISVPGLGENVAKRIVEARDDGPFLSKEDLNKKAGLSQKIIEYLDELGSLPNLPDKAQLSIFDM
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_BARBK
Sequence: MSLTIAIVGRPNVGKSTLFNRLVGKKLALVDDKPGVTRDRRIHAARFQDLYFDVIDTAGLEEADDHTLEGRMRSQTKVAIDEADLILFVLDAKSGITSSDLNFASLVRKSEKPIVLVANKSESKAATEGKYEAWSLGLGEPCAISAEHGLGLSDLRDAIVDAVGKDKAFDNKKEEDTIIQSASVGDNGDDLEEEGCIYDESAPIRIAIAGRPNTGKSTLINSMLGQDRLLTGPEAGVTRDSISIDWEWRSRHIKLFDTAGLRRKSKIQEKLEKLSVTDTLRAIRFAEVVVIVFDSTAPFEKQDLQIVDLVIREGRVPIIAFNKWDLIENCQEILADLHEKCACLLPQVRGLRAVPLSGQYGQGIDKLMENITMIHRIWNRRISTGKLNRWLETVVTRHPPPAISGRRLKVKYITQIKTRPPGFMISCSRPEVMPQSYLRYLSNGLRDAFDMPGVPIRLSLRTSDNPFVGSAKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: NU1M_GORGO
Sequence: MSMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPSTSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMNGSFNLSTLIMTQEHLWLLLPTWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPLALFFMAEYMNIIMMNTLTTMIFLGTTYNAHSPELYTVCFITKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALLMWYISMPTTISSIPPQT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EFP_RICFE
Sequence: MKISANSIRTGNILVYNNDLWVVSKTPEHTQPGKGGAYVQVEMKNLKTGTKRNERFSSSDYLEKAELEQKDYQFLYFEGDDLVLMDTKHFEQINVPKEILEEKLPFLTENMIVKVEFYNEKPLNIELPPTVILEINETDPVIKGATATASYKPAILENGIKVKVPQYLEVGEKIVVKTDDMTYVERAK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACG_STRPB
Sequence: MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWYTAEPASDFYNRYPVDLKLSEEFGVNGIRISIAWSRIFPTGKGEVNPKGVEYYHNLFAECHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVNYAELCFKEFSEVNYWTTFNEIGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLFKDSGYSGEIGVVHALPTKYPFDANNPDDVRAAELEDIIHNKFILDATYLGKYSDKTMEGVNHILEVNGGELDLREEDFAALDAAKDLNDFLGINYYMSDWMQAFDGETEIIHNGKGEKGSSKYQIKGVGRRKAPVDVPKTDWDWIIFPQGLYDQIMRVKADYPNYKKIYITENGLGYKDEFVDNTVYDDGRIDYVKKHLEVISDAISDGANVKGYFMWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWYKKVAETQVIE
What are the official names of this protein?
6-phospho-beta-galactosidase, Beta-D-phosphogalactoside galactohydrolase, PGALase, P-beta-Gal, PBG.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: YAII_SALPA
Sequence: MTIWVDADACPNVIKEILYRAAERMQLPLILVANQALRVPPSRFIRTLRVAAGFDVADNEIVRQCEAGDLVITADIPLAAEVLEKGAAALNPRGERYSDATIRERLTMRDFMDTLRASGVQTGGPNTLSPRDRQHFAAELDKWWLESQRKK
What are the official names of this protein?
UPF0178 protein YaiI.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: BCSC3_KOMXY
Sequence: MNRRYVFSLSAGLLASSCMGAIMPVPVARAQQASTAMTGAQATGGTAAPRQILLQQARFWLQQQQYDNARQALQNAQRIAPDAPDVLEVQGEYQTAMGNREAAADTLRHLQEVAPGSVAANSLSDLLHERSISTGDLSHVRSLAASGHSAEAVAGYQKLFNGGRPPHSLAIEYYQTMAGVPADWDQARAGLAGLVAANPQDYRAQLAFAQTLTYNTSTRMEGLARLKDLQGFRTQAPVEAAAAAQSYRQTLSWLPVTAETQPLMQQWLTAHPDDTALKEHMLHPPGGPPDKAGLARQAGFQQLNSGRLSAAEQSFQSALQINSHDADSLGGMGLVSMRQGDAAEARRYFQEAMAADPKTADRWRPALAGMEISGDYAAVRQLIAAHQYTEAKQRLTSLARQPGQFTGATLMLADLQRTTGQIDASEQEYRSVLARDPNNQLALMGLARVDMAQGNTAEARQLLSRVGPQYATEVGEIEVTGLMAAASHTSDSARKVAILREAMTQAPRDPWVRINLANALQQQGDVAEAGRVMQPILANPVTAQDRQAGILYTYGAGNDAATRRLLSGLSPEDYSPAIRSIAEEMQIKEDLASRLSMVPNPVPLIREALAPPDPTGARGVAVADLFRQRGDMIHARMALRIASTRTIDLSPDQRLAYATEYMKISNPVAAARLLAPLGDGSGSGAGNALLPEQQQTLQQLRMGIAVAQSDLLNQRGDQAQAYDHLAPALRADPEATSPKLALARLYNGEGKSSKALDIDLAVLRHNPQDLDARQAAVQAAVNSGRKSLATHLAMDGVQESPMDARAWLGMAVADQADGHGHRTIADLRRAYDLRLQQVEGSRSASGPAATEEDALAPPSSNPFRHHGYGRQTELGAPVTGGSYSMEATSPEAADQMLSSISGQINTLRENLAPSIDGGLGFRSRSGEHGMGRLTEANIPIVGRLPLQAGESSLTFSITPTMIWSGDLNAGSVYDVPRYGTNMATEAYNQYVNSLSQNNSSSSLRTQQIQGGQGEAGFAPDVQFSNSWVRADVGASPIGFPITNVLGGVEFSPRVGPVTFRVSAERRSITNSVLSYGGLRDPNYNSALGRYALNHYGSQLASQWGQEWGGVVTNHFHGQVEATLGNTILYGGGGYAIQTGKNTRSNNEREAGIGANTLVWHNANMLVRIGVSLTYFGYANNQDFYTYGQGGYFSPQSYYSATVPIRYAGQHKRLDWDVTGSVGYQVFHEHSSPFFPTSSLLQSGAQYIADSYMQNATASDYLSEETVDRAYYPGDSIASLTGGFNARVGYRFTHNLRLDLSGRWQKAGNWTESGAMISVHYLIMDQ
What is the function of this protein?
Required for maximal bacterial cellulose synthesis.  It may be involved in the formation of a membrane complex for extrusion of the cellulose product (By similarity).
What are the official names of this protein?
Cellulose synthase 1 operon protein C.
What is the protein family that this protein belongs to?
Belongs to the AcsC/BcsC family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: Y3002_YERPA
Sequence: MSAIALTVSMLALVAVLGLWIGNWKIYGVGLGIGGVLFGGIIVGHFAQTYQIVLNGDMLHFIQEFGLILFVYTIGIQVGPGFFSSLRVSGLRLNCFAILMVVVGGLVTAIIHKLFAVPLPIILGVFSGAVTNTPALGAAQQILTDLGSPPQLVSQMGMGYAMAYPFGICGILLVMWLIRLFFKINIDREAKAFDSSYGQNRELLQTMNVAVRNPNLHGLSVQDVPLLNSDEVVCSRLKRGDLLMVPMPATVIEIGDYLHLVGQRDALEKVRLVVGEEVDVTLSTAGTALQTARVVVTNEAVLGKKIRDLNLKQKYDVVITRLNRAGIELVASNSASLQFGDILNLVGRPEAIEAVSAIVGNAQQKLQQVQMLPVFIGVGLGVLLGSIPLFVPGFPAALRLGLAGGPLVVALILGRIGSIGKLYWFMPPSANLALRELGIVLFLSVVGLKSGGDFINTLVNGDGLAWIGYGAMITGIPLLTVGILARMLVKMNYLTLCGMLAGSMTDPPALAFANGLHPTSGAAALSYATVYPLAMFLRIMSPQILAVLFWTL
What are the official names of this protein?
Putative transport protein YPA_3002.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LEUD_STAAC
Sequence: MAAIKPITTYKGKIVPLFNDNIDTDQIIPKVHLKRISKSGFGPFAFDEWRYLPDGSDNPDFNPNKPQYKGASILITGDNFGCGSSREHAAWALKDYGFHIIIAGSFSDIFYMNCTKNAMLPIVLEKSAREHLAQYVEIEVDLPNQTVSSPDKRFHFEIDETWKNKLVNGLDDIAITLQYESLIEKYEKSL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: C7D13_PANGI
Sequence: MELQFPLFSIFFVTILFFFLFKKSSKTTKNLPPGPRKLPIIGNILELAGEVQHRVLAELSQKHGPIMHLQLAEISAIVVSSSKVAKEVLKTHDLAFSDRAQLQLSKIILKGCKDVVFNDYDDYWRQMRKICTVELLTANKVNSFRAIREDEAWNLVESIKTSLDSPVNLTHKFTSLTNAITCRAAIGERSKYQDELVHLIELMAALGGGFDIADLFPSYKFLHFLSGLRSKLEKVRKRLDDIFYNILKEHEEKRAKTKNSDGRVAGEEDLVDVLLRVQEKGGLQFPISSNNIQGIICDMLTAGTDTASTALDWAMSELVRYPSVLHKAQAEVREAFKGKTKIHEDDVQGLSYLKLVIKETLRLHPPAPLLLPKECREQCVIEGYTIPVRTKLIVNAWAIGRDPEYWVNAESFDPERFSNKSIDYNGTNLNYIPFGAGRRSCPGIAFGIATIELPLALLLYHFNWGMPGGIKPSALDMNEVLGATLKRKTNLLLSATSYTPNEDSS
What is the function of this protein?
Probable heme-thiolate monooxygenase.
What are the official names of this protein?
Cytochrome P450 CYP71D313.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ERA_STRMU
Sequence: MSFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEKRGKGDNMIIERLKAAKVPVILVINKIDKVHPNQLLEQIDDFRNQMDFQEIVPISALQGNNVSHLVDLLVDHLEEGFQYFPADQITDHPERFLVSEMIREKVLLLTREEIPHSVAVVIDSMARDEETHKIHIRATIMVERDSQKGIIIGKKGAMLKKIGQMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNKKEY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity).  Has GTPase activity, binds both GDP and GTP, does not bind UTP, CTP or ATP.
What are the official names of this protein?
GTPase Era, SGP.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: REP1_ORYSJ
Sequence: MGRVISSWRVLAVVAALMAMAAVELCAAIPFDERDLESDEALWDLYERWQEHHHVPRHHGEKHRRFGAFKDNVRYIHEHNKRGGRGYRLRLNRFGDMGREEFRATFAGSHANDLRRDGLAAPPLPGFMYEGVRDLPRAVDWRRKGAVTGVKDQGKCGSCWAFSTVVSVEGINAIRTGRLVSLSEQELIDCDTADNSGCQGGLMENAFEYIKHSGGITTESAYPYRAANGTCDAVRARRAPLVVIDGHQNVPANSEAALAKAVANQPVSVAIDAGDQSFQFYSDGVFAGDCGTDLDHGVAVVGYGETNDGTEYWIVKNSWGTAWGEGGYIRMQRDSGYDGGLCGIAMEASYPVKFSPNRVTPRRALGAKETQ
What is the function of this protein?
Cysteine endopeptidase that digests in vitro both the acidic and basic subunits of glutelin, the major seed storage protein of rice (PubMed:8706734).  Acts as negative regulator of cell death (PubMed:23938390).
What are the official names of this protein?
Cysteine endopeptidase Rep1, Cysteine proteinase SAG12, Protein SENESCENCE-ASSOCIATED GENE 12, OsSAG12, Senescence-specific cysteine protease SAG12.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Protein storage vacuole.
Protein: RR18_EUCGG
Sequence: MEKSKRLFLKSKRSFRRRLPPIQSGDRIDYRNMSLISRFISEQGKILSRRVNRLTLKQQRLITIAIKQARILSLLPFLNNEKQFERSESTAGATGLRTINK
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YCIB_HERAR
Sequence: MKFLFDLFPVILFFAVFKWGEGNADAAQAFGQQFLSGLVSGGQVTVTQAPILLATAIAIIATILQIGYLLSRRKKVDGTLWLSLAIIVFFGGATIYFHNETFIKWKPTVLYWCFAAALLFSQIFLNKNLIRTMMEKQMSLPDGVWRRVNLSWVAFFITMGLLNLYVAFNFSTAAWVNFKLFGGMGLMFAFIIIQSLLLSKYLKEPQ
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MBL1_GIBM7
Sequence: MLTSPLRQDHLVPETLMADASPIIRPETPPDLHIPDSQATVKVSIIDTTSYMSNFPMWAFLDPLMPGHEEMKGCDFSFIIEHPKSGNKYDTLLFDLGVRKDWENLPTPFVQGIKAGGCKIEVQKDVATILKDNGRDLSEVGGIIWSHWHFDHVGDAQTFPGTTDVIVGPGFKKAHVPAWPTDPESHIDEKAWQGRTLREIDFAAEEGKGLKIGQFDALDFYGDGSFYVLNTPGHTIGHLSALARTTVDPPTFIFMGGDIAHQGGEFRPTPYMPLPAEISPNPFNRILPRPALTCPGEIFVEIHRNKSRTEPFFDPTTAEGAWHHCAHEAKRSIDKLTEFDAYENIFPVIAHDNSLYGVIDVYPKPANDWFAKSWKDKTRWGWLNEFDPSFAGLAKASEP
What is the function of this protein?
Gamma-lactamase; part of the Fusarium detoxification of benzoxazolinone cluster 1 (FDB1) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:19302487, PubMed:26808652).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).  The first step in the detoxification of benzoxazolinones involves the hydrolysis of the cyclic ester bond of benzoxazolinones by the FDB1 cluster gamma-lactamase MBL1 to aminophenols (PubMed:26808652, PubMed:12788712).  MBL1 is able to convert BOA into 2-aminophenol (2-AP), as well as MBOA into 5-methoxy-2-aminophenol (2-AMP) (PubMed:26808652, PubMed:12788712).  The FDB2 cluster N-malonyltransferase FDB2/NAT1 then metabolizes aminophenols via N-malonylation to non-toxic malonamic acids (PubMed:19302487, PubMed:12788712).  FDB2/NAT1 converts 2-AP into N-(2-hydroxyphenyl) malonamic acid (HPMA) and 2-AMP into N-(2-hydroxy-4-methoxyphenyl) malonamic acid (HMPMA) (PubMed:19302487, PubMed:12788712).  The duplicated dienlactone hydrolases DLH1 and DLH2 may provide redundant function for hydrolyzing the lactone moiety in the BOA molecule (Probable).  The roles of the amidases and other enzymes encoded by the 2 FDB clusters have not been identified so far (Probable).
What are the official names of this protein?
Gamma-lactamase MBL1, Fusarium detoxification of benzoxazolinone cluster 1 protein MBL1, FDB1 cluster protein MBL1, Metallo-beta-lactamase 1.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: EGLN2_HUMAN
Sequence: MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
What is the function of this protein?
Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902).  Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519).  Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211).  Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519).  Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519).  Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519).  Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519).  Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519).  EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519).  Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519).  Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902).  Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296).  Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity).
What are the official names of this protein?
Prolyl hydroxylase EGLN2, Egl nine homolog 2, Estrogen-induced tag 6, EIT-6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, Prolyl hydroxylase domain-containing protein 1, PHD1.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTH_METMA
Sequence: MSEYKQCIVTRDDLKLSKGKFAVQVAHAALSAAEWASKGDLEKWKEGGQKKIVLKVPSIKELYELKEKARREGLPTALIQDAGLTEIPPGTVTVLGIGPAKEELIDKITKDLKLV
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZC3HF_XENLA
Sequence: MPPKKAPAAPQASKKTEQKKKEKIIEDKTFGLKNKKGAKQQKFIKNVTHQVKSGQQNPRLVAQAEGDKKNKKDDKMKELQELNDLFKPVVVAQKVSKGADPKSVVCAFFKQGQCTKGDKCKFSHDLSLERKCEKRSVYVDGRDDELEKDTMENWDEKKLEEVVNKKHGEAEKIKAKTQIVCKFFLEAIENNKYGWFWVCPGGGDTCMYRHALPPGFVLKKEKVKEDKDEDISLEDLIEKERAALGPNVTRITLESFLQWKKRKRADRILKLEEEMEKRKEDFKSGKSLGVSGREVFEFRPELINDDDEEADDASYTFELEDSEAEEIDDVQDIDLSRYVLKDVDETGITVASCERFSSYVASTEKDENKLCVASGGVMENENQSEEEQEGDLENGFVDAVPVDENLFTGEDMDELEEELYTLDLEK
What is the function of this protein?
Protects drg1 from proteolytic degradation.
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 15, DRG family-regulatory protein 1.
What is the protein family that this protein belongs to?
Belongs to the ZC3H15/TMA46 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: UPP_BACLD
Sequence: MGKVYVFDHPLIQHKLTYIRDVKTGTKEFRELVDEVATLMAFEITRDLPLEEVNVETPVQMAKSNVIAGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGLYRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEALNSLKKRGAKNIRFMCLIAAPEGVDEVQKHHPDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: YB076_YEAST
Sequence: MHVHKGLIFLSFFSPIYLSLLLNGSIFFFYYAQRALHDSFFFPNELLRCQICLCSLFWMVTVINLKRFFARMVNISIYQPSRNRLVRY
What are the official names of this protein?
Putative uncharacterized protein YBR076C-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: T1M_SALTY
Sequence: MNNNDLVAKLWKLCDNLRDGGVSYQNYVNELASLLFLKMCKETGQEADYLPEGYRWDDLKSRIGQDQMQFYRNLLVQLGSDEKKLVQAVFHNVSTTIEQPKQLTELVSYMDALDWYNGNHGKSRDDFGDMYEGLLQKNANETKSGAGQYFTPRPLIKTIIHLLKPQPREVVQDPAAGTAGFLIEADRYVKSQTNDLDDLDGDTQDFQIHRAFIGLELVPGTRRLALMNCLLHDIEGNLDHGGAIRLGNTLGSDGENLPKAHIVATNPPFGSAAGTNITRTFVHPTSNKQLCFMQHIIETLHPGGRAAVVVPDNVLFEGGKGTDIRRDLMDKCHLHTILRLPTGIFYAQGVKTNVLFFTKGTVTNPHQDKNCTDDVWVYDLRTNMPSFGKRTPFTEQHLQPFETVYGEDPHGLSPREEGEWSFNAEESEVADSEENKNTDQHQATSRWRKFSREWIRSAKSDSLDISWLKDKDSIDADSLPEPDVLAAEAMGELVQALGELDALMRELGAGDEADAQRQLLNEAFGEVKA
What is the function of this protein?
The subtype gamma methyltransferase (M) subunit of a type I restriction enzyme.  The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues of the sequence 5'-GAGN(6)GTRC-3'.  In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site.  Whether the DNA is cut or modified depends on the methylation state of the target sequence.  When the target site is unmodified, the DNA is cut.  When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated.  After locating a non-methylated recognition site, the enzyme complex serves as a molecular motor that translocates DNA in an ATP-dependent manner until a collision occurs that triggers cleavage.
What are the official names of this protein?
Type I restriction enzyme StySJI methylase subunit, M protein, Type I methyltransferase M.StySJI, M.StySJI, Type I restriction and modification system SB.
What is the protein family that this protein belongs to?
Belongs to the N(4)/N(6)-methyltransferase family.
Protein: TX2A_NEOAP
Sequence: GKEKDVFMDKLRDAGAAGIDYLKHFTHHIVKKKN
What is the function of this protein?
May have antimicrobial properties, like most ant linear peptides.
What are the official names of this protein?
U1-poneritoxin-Na2a, U1-PONTX-Na2a, Poneratoxin, Ponericin Pa IV1.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAE2_BRUME
Sequence: MVPYFEMAAASNFSFLCGASHPQELVERAHALDLSGIGIADRNTLAGVVRAHAQWKDIRKESGFRLFIGCRLSFIDGTPDMVVYPRDRAAYGQLCRLLTEGKHRAAIKGECHLEWADLLFRARQFQIAVFPPDEDEPDFAARLTEIAQAAPGSVWLALTMPHQGQDGRRAERIARFAAQAGVPLIATNDVLYHHPDRRPLQDVLTATRHHTTVFAAGRLLEKNAERHLKPPHEMVRLFRDYPEAIAATADFVAPITFQLDELKYAYPDEPIPPGKTAQQHLYDLVWEGAARHYGADMIPPKVQGLINKELALIARLEYEPYFLTVYDIVTHAREKGILCQGRGSAANSVVCFCLGITGVNPTQVDLLFERFISAERKEPPDIDVDFEHERREEVMQYVYDRYSRDRAAIVATVISYRSRSAIRDVGKALGLSEDVTAALANTVWGLSGGGIDRQHIRQAGLDPDNPIIQRAVELAITLIGFPRHLSQHVGGFVLTRDRLDETVPIGPAAMDKRSFIEWDKDDIDEVGLMKVDVLSLGMLTCIRKAFDLIHQHKPQLYGGEKLTLASLPRKDKAVYDMLCKGDSLGVFQVESRAQMNMLPRLRPQEFYDLVIEVAIVRPGPIQGDMVHPYLRRRSGQEPCTLPSPSPQHGPANELQQILGKTKGVPLFQEQAMRIAMEAAKFTPEEANQLRRAMATFRKMGTIHTMEKKMIDGMVNRGYDRTFAENCFNQIKGFGEYGFPESHAASFAHLVYISAWLKCHHPEVFAAALLNSQPMGFYAPAQIVRDAREHGVTVLPVDVNFSQWDNILEETPDVHLALRLGFRQIDGFSKRDTELLIADRQEPYRTIEDMHRRLRLDRRAFTLLADADAFGSLDIDRRAALWAVRRLPNDETLLLFRAAAASELAQEPRTKLPEMAASEHVIADYETTRLSLKGHPLQYLREGLAAEGVSTCRAVQEGADGRRMKVAGVVTVRQRPGSAKGVVFLTIEDETGIANIVIWPKIMKVFRREVMSARLIHIEGRIQRSLEGVVHLVAAKLQDRSAALIEMSGREAQRLIAPSQMAHHPRNVRVMPNSRDFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PR15L_MOUSE
Sequence: MTEVGWWKLTFLRKKKSTPKVLYEIPDTYAQTEGGAEPPGPDAGDPHSDFNSRLEKIVDKNTKGKHVKVSNSGRFKEKKKVRAMLAENPNLFDDRENKGQ
What are the official names of this protein?
Proline-rich protein 15-like protein, Protein ATAD4.
What is the protein family that this protein belongs to?
Belongs to the PRR15 family.