PharMolix/UniProtQA huggingface dataset:
Protein: GLGB_OLEA2
Sequence: MATPVESGTVPCSLEPFDVYLFGRGEHWDIYRVLGAHAHAQDGETGYRFAVWAPNAHAVSLVGPFNDWRSGDFPLFPVGTSGIWAGFVAGMEYGRLYKFAVQGADGTVRLKTDPYALYCEMRPGTASFTWSLDSYAWNDAAWMQRRREAGPPLQQPVSIYELHAGSWMRRHGEGHPFVNWDELAGTLIPYVRDAGFTHIELMPVAEHPLDQSWGYQTGAYYAPTSRFGTPDDLRRFVDLCHQQGIGVILDWVPAHFPKDDWSLGRFDGTALYEHLDPRLGEHPDWGTYVFNYGRHEVRNFLFANALYWFKEFHVDGLRIDAVASMLYLDYSRKEGEWLPNVHGGNENLEAIDFLRELNRVVHEQYPGVMMIAEESTSWPGVSRPLYTGGLGFTFKWNMGWMHDTLNYMRQDPVFRAYQHSSLTFSMLYAFSENFVLPLSHDEVVHGKGALLSKMPGDMWQQQANLRLMYAYMWAHPGKKLLFMGGEIGQWNEWSESREPDWCLREFPAHEGIRNLVRDLNGIYAQEPAMHRHDHDWSGFRWLDFSDYGCSVISFARFAEDSPPVMWVFNFTPVVRRWYRVPCPRAGEWQEVLNTDSGYYGGSNVGNGGGAVACTDNWHGGHFMELTLPPLAAVALKPV
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: SPAN1_BPT3
Sequence: MLEFLRKLIPWVLAGMLFGLGWHLGSDSMDAKWKQEVHNEYVKRVEATASTQRAINEISAKYQEDLAALEGSTDRIISDLRQDNKRLRVRVKPTGTSEGQCGFEPDDRAELDDRDAKRILSVTQKGDAWIRALQDTIRELQRKQEIK
What is the function of this protein?
Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit.  The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans.  Host outer membrane disruption is possibly due to local fusion between the inner and outer membrane performed by the spanin complex.
What are the official names of this protein?
Spanin, inner membrane subunit, i-spanin, Gene product 18.5, Gp18.5.
What is the protein family that this protein belongs to?
Belongs to the T7likevirus i-spanin family.
What are the subcellular locations of this protein?
Host cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: SAER_STAAM
Sequence: MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGYDIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMKKYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
What is the function of this protein?
Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion.  Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes (By similarity).
What are the official names of this protein?
Response regulator SaeR, Staphylococcus exoprotein expression protein R.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPO13_HUMAN
Sequence: MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQQGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY
What is the function of this protein?
Functions in nuclear protein import as nuclear transport receptor.  Serves as receptor for nuclear localization signals (NLS) in cargo substrates.  Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).  Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family.  Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
What are the official names of this protein?
Importin-13, Imp13, Karyopherin-13, Kap13, Ran-binding protein 13, RanBP13.
What is the protein family that this protein belongs to?
Belongs to the importin beta family.
Protein: RPOC1_ACAM1
Sequence: MPKLEQRFDYVKIGLASPERIRQWGERTLPNNQVVGEVTKPETINYRTLKPEMDGLFCERIFGPAKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGYIKLAAPVTHVWYLKGIPSYMATLLDMPLRDVEQIVYFNAYVVLDPGNADTLSYKQLLTEDQWIEIEDQIYSEDSQLEGIEVGIGAEAVQRLLQDIKLETEAETLREDIGNAKGQKRAKLIKRLRVIDNFVGTGSQTDWMVLSVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKMHQCGLPKEMAIELFQPFVIHRLIGQGLVNNIKAAKRLIQRNDPVIWDVLEEVIEGHPVMLNRAPTLHRLGIQAFEPILVDGRAIQLHPLVCPAFNADFDGDQMAVHVPLSIEAQSEARLLMLASNNILSPATGRPIVTPSQDMVLGAYYLTADNPGRQNGAGKYFAGLDDAIMAYEQQQVDLHAYVWVRFDGPVDDGEDDVEPEVETSADGVVTQTYPSRRIRKDADGTLISQYIRTTPGRIIYNKTIQDSLAS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: LEUC_METB6
Sequence: MGSTIVEKIFSRKCGSDIKAGEVVMAPIDGAMIHDITGPLAIRKFYEMGGKQVFDPKSVIMLFDHQIPADSLEAAENHVFMRKFAAEQGIHNYDINEGVCHQVVLEKGRAAPGEIVVGADSHTCMYGAVGAFATGIGSTDMGFALKFGALYFKVPETVRAEISGKFQKRVGAKDLILSIAADIGADGATYQAIEFTGKTISKMDMAGRMTCCNMAIEMGAKAGIVPPDKVTWEYMKGRRKITPFALASDDDAKFAEKRTYNVADLEPQVAVPHNVDQGIPVGKVEGTHIDQVFIGSCTNGRYEDLVEAAEVLGKKKFDPKVRVLVIPASRDEYLKALEAGLVERFVRAGALVEAPCCGPCMGGSFGLIAAGEVSLATSNRNFRGRQGSTEGKVYLCSPATAAASAIKGEITDPREV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: F16P1_RABIT
Sequence: MADKAPFDTDISTMTRFVMEEGRKAGGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSTKDALQPGRNLVAAGYALYGSATMLVLAGGSGVNSFMLDPAIGEFILVDKNVKIKKKGNIYSLNEGYAKDFDPAVTEYIQKKKFPPDNSSPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPDGKLRLLYECNPMAFIMEKAGGMATTGKEAILDIVPTDIHQRAPVILGSPDDVQEFLEIYKKHAVK
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis.  Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells.  Appears to modulate glycerol gluconeogenesis in liver.  Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
What are the official names of this protein?
Fructose-1,6-bisphosphatase 1, FBPase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, Liver FBPase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
Protein: UBIE_LEGPA
Sequence: MTNQKQTTHFGFKSVDWNEKEKKVAEVFHSVAKNYDRMNDLMSLGIHHLWKRYTIELSHVRPGQSVLDLAGGSGDLTRLLSQKVGDSGQVVLADINAAMLHVGRDRLLDEGLFKNIRYVQGNAQCLPFADNSFHCITMGFGLRNVTDKDEALQSMYRVCKPGGKLMVLEFSTPVFPGLKPVYDWYSFNILPKIGKFVANDEASYQYLAESIRMHPDQETLKAMIERVGFEDCHYHNLSGGIVALHIAYKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: GPDA_BACAH
Sequence: MTKITVVGAGSWGTALAMVLADNGHDVRIWGNRSELMDEINTKHENSRYLPGITLPSTIVAYSSLEEALVDVNVVLLVVPTKAYREVLQDMKKYVAGPTTWIHASKGIEPGTSKRISEVIEEEIPEDLIKDVVVLSGPSHAEEVGLRQATTVTSAAKRMEAAEEVQDLFMNSYFRVYTNPDIVGVELGGALKNIIALAAGITDGLGLGDNAKAALMTRGLTEIARLGRKMGGNPLTFAGLTGMGDLIVTCTSVHSRNWRAGNMLGKGHSLEEVLESMGMVVEGVRTTKAAHELAEKMEVEMPITAALYDVLFNGNNVKDAVGSLMGRVRKHEVEAIPDLL
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5NTC_RAT
Sequence: MMTSWSDRLQNAADVPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLNFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCDTGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEE
What is the function of this protein?
Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:6260203).  In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (By similarity).  Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:6260203).  Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (By similarity).  Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:6260203).
What are the official names of this protein?
Cytosolic purine 5'-nucleotidase, Cytosolic nucleoside phosphotransferase 5'N.
What is the protein family that this protein belongs to?
Belongs to the 5'(3')-deoxyribonucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RRP36_MAGO7
Sequence: MELSGRKRKAAFDPERRVKVRRRDVEKADAWEPPSEDEQDARSSSPAEESDQGQEEDDVDEEDEEESGASEPEDDREAQLSFGARLRLSQKRQKPKPKGSTEQDPSDAQEPSWRGREARQGNAKTVSKAAASASAPGRKTKSAPEEMSSKRPVSRYREVVKPPPNARPKPRDVRFEQELTGEDYQRFRRNYAFLDEYRNDEMAKLREIIARKKGVTPADREDAKLKLRKMEDEKRSQDRKDREHELMREHKKKEKELVKQGKKPFFLKKSEQKKLLLMDKYAGMSKGQVDKAIEKKRKKVAGKEKKQLPFARRAME
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ACPS_MYCS2
Sequence: MAIVGVGIDLVSIPDFAEQVDRPGTVFAETFTPGERRDAADKSSSAARHLAARWAAKEAVIKAWSSSRFSKRPALPEGIHRDIEVVTDMWGRPKVRLSGEIAKHLEDVTIHVSLTHEDQTAAAVAIIEEP
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALS2_ARATH
Sequence: MAQRKGPDPPPPQRRILRTQTAGNLGEAMLDSEVVPSSLVEIAPILRVANEVEASNPRVAYLCRFYAFEKAHRLDPTSSGRGVRQFKTALLQRLERENETTLAGRQKSDAREMQSFYQHYYKKYIQALQNAADKADRAQLTKAYQTAAVLFEVLKAVNQTEDVEVADEILEAHTKVEEKSQIYVPYNILPLDPDSQNQAIMRFPEIQATVSALRNTRGLPWPAGHKKKLDEDMLDWLQTMFGFQKDNVSNQREHLILLLANVHIRQFPRPEQQPRLDDRALTIVMKKLFKNYKKWCKYLGRKSSLWLPTIQQEVQQRKLLYMGLYLLIWGEAANLRFLPECLCYIYHHMAFELYGMLAGSVSPMTGEHVKPAYGGEDEAFLQKVVTPIYKTIAKEAKRSRGGKSKHSEWRNYDDLNEYFWSIRCFRLGWPMRADADFFCQTAEELRLDRSENKPKTGDRWMGKVNFVEIRSFWHIFRSFDRMWSFYILSLQAMIIIAWNGSGKLSGIFQGDVFLKVLSIFITAAILKLAQAVLDIALSWKSRHSMSFHVKLRFIFKAVAAAIWVVLMPLTYAYSWKTPSGFAETIKNWFGGHQNSSPSFFIIVILIYLSPNMLSTLLFAFPFIRRYLERSDYKIVMLMMWWSQPRLYIGRGMHESALSLFKYTMFWVVLLISKLAFSFYAEIKPLVKPTKDIMRVHISVYRWHEFFPHAKSNMGVVIALWSPVILVYFMDTQIWYAIVSTLVGGLNGAFRRLGEIRTLGMLRSRFQSLPEAFNACLVPNEKSETPKKKGIMATFTRKFDQVPSSKDKEAARFAQMWNKIISSFREEDLISDREMELLLVPYWADRDLDLIRWPPFLLASKIPIALDMAKDSNGKDRELTKRLSVDSYMTCAVRECYASFKNLINFLVVGEREGQVINEIFSRIDEHIEKETLIKDLNLSALPDLYGQFVRLIEYLMENREEDKDQIVIVLLNMLEVVTRDIMDEEVPSMLESTHNGTYVKYDVMTPLHQQRKYFSQLRFPVYSQTEAWKEKIKRLHLLLTVKESAMDVPSNLEARRRLTFFSNSLFMEMPDAPKIRNMLSFSVLTPYYSEDVLFSIFGLEKQNEDGVSILFYLQKIFPDEWTNFLERVKCGSEEELRAREELEEELRLWASYRGQTLTKTVRGMMYYRKALELQAFLDMAKDEELMKGYKALELTSEDASKSGTSLWAQCQALADMKFTFVVSCQQYSVQKRSGDQRAKDILRLMTTYPSLRVAYIDEVEQTHKESYKGADEKIYYSALVKAAPQTKSMDSSESVQTLDQVIYRIKLPGPAILGEGKPENQNHSIIFTRGEGLQTIDMNQDNYMEEAFKMRNLLQEFLVKHGGVRTPTILGLREHIFTGSVSSLAWFMSNQENSFVTIGQRVLASPLKVRFHYGHPDVFDRLFHLTRGGVCKASKVINLSEDIFAGFNSTLREGNVTHHEYIQVGKGRDVGLNQISMFEAKIANGNGEQTLSRDLYRLGHRFDFFRMLSCYFTTIGFYFSTMLTVLTVYVFLYGRLYLVLSGLEEGLSNQKAFRSNMPLQAALASQSFVQIGFLMALPMMMEIGLERGFHNALIDFVLMQLQLASVFFTFQLGTKTHYYGRTLFHGGAEYRGTGRGFVVFHAKFAENYRFYSRSHFVKGIELMILLLVYQIFGHAYRGVVTYILITVSIWFMVVTWLFAPFLFNPSGFEWQKIVDDWTDWNKWIYNRGGIGVPPEKSWESWWEKEIGHLRHSGKRGIILEIVLALRFFIFQYGLVYQLSTFKQENQSLWIYGASWFVILFILLIVKGLGVGRQRFSTNFQLLFRIIKGFVFLTFLGLLITFLALRFLTPKDIFLCMLAFMPTGWGMLLIAQACKPLIQRLGFWSSVRTLARGYEILMGLLLFTPVAFLAWFPFVSEFQTRMLFNQAFSRGLQISRILGGQRKDRSSKNKE
What is the function of this protein?
Involved in callose synthesis at the forming cell plate during cytokinesis.  During plant growth and development, callose is found as a transitory component of the cell plate in dividing cells, is a major component of pollen mother cell walls and pollen tubes, and is found as a structural component of plasmodesmatal canals (By similarity).
What are the official names of this protein?
Callose synthase 2, 1,3-beta-glucan synthase, Protein GLUCAN SYNTHASE-LIKE 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 48 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNFG_HAEI8
Sequence: MGTVKITSRYGILLGFIALLCTIISTGIFFLTKDKIDAVIAAQQRELLLQVIPQDYFNNNLLESAVIPQDKNFVGIQKIYFAKKDGNISAYAYETTAPDGYSGDIRLLVGLDPKGEVLGVRVIEHHETPGLGDKIERRISNWILGFTNQSINEHNLSEWAVKKDGGKFDQFSGATITPRAVVNQTKRSALIMLNNQALLQQLSTQVK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit G, Rnf electron transport complex subunit G.
What is the protein family that this protein belongs to?
Belongs to the RnfG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TXF3B_SCODE
Sequence: MEKKIIFLCFLVALLTFPEFISSEVIRDSVIHDEEKFANRSYCIKTCATEFTGGDESRIKDVRPRHYKCVCWYYSD
What are the official names of this protein?
U-scoloptoxin(15)-Ssd3b, U-SLPTX(15)-Ssd3a, Toxin SSD1014.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-15 family.
What are the subcellular locations of this protein?
Secreted.
Protein: OGA_OCEGH
Sequence: MLTGVIEGFYGRDWRRDERATVMDWIAAAGMNTYIYGPKDDVHVRARWRVPYDAAGLARLTELRDAAAARGMVFYVSLAPCLDVTYSDPQDRAALLARVDQLARAGLRNLVLLFDDIPSVLPEADRHRFDSFAEAQADLSNMVLRHLRGAGHVVFCPTEYCGRMAGGDPRGSAYLQRLGSTLDPAIDIFWTGPEIVSEEIVAAHLAAVGEVLRRRPVIWDNFHANDYDIRRVFAGPLGGRSRDILPLVAGWITNPNNEAEANFPAIHTTGAYLADPDYAPERAIAAAVAAWQPRFRLAFGDGAVPSDLVALLCDLFWQPFALGPETTRILSALRAALTVPRPDPSDPAWRAALEDLRDLKRRINKLFTLMTEIENRDLFHTFHNYLWEAQEEVGHLVAYCDWLDEAPPPGAVFPATDRIHNFYRRGFGVAVQDILQRDRQGRYHHGV
What is the function of this protein?
Cleaves GlcNAc from O-glycosylated proteins.  Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrate (in vitro).
What are the official names of this protein?
Protein O-GlcNAcase, OGA, Beta-N-acetylglucosaminidase, Beta-N-acetylhexosaminidase, Beta-hexosaminidase, N-acetyl-beta-D-glucosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 84 family.
Protein: FEN1_PLACH
Sequence: MGIKGLTKFIADTAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDGDQYGNLMNEAGETTSHISGLMSRTIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLLKAKEEGNLEEIKKQSGRTVRVTKKQNEEAKKLLTLMGIPVIESPCEAEAQCAFLTKYDMAHATATEDADALVFGTKILIRNLNANASSNKNKNKNSSKRGYILTEINLEQVLKGLKLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIENIIKNIDQNKYQVPDNFKYVEARQSFINPKVLEKSEVKIDWCEPKIEELKTFLIKEHNFNEVRVTNYITRLLKARKVTTQRRLDTFFTTCTKKSTKLIIEESQKELLKAKGKGKKRELNDNSTKLNAKKKKTNIKDEKKNTDKMDELKNKSDENFVKDEENDQDDYDQNLFDEKTNSDSGNIKNENIKEDISSNDITMDIPKCTNDIVC
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: TIRR_CHICK
Sequence: MGVMAAVGALPAGAGSLPPLPTLGVPGVPELKPLTRYEAMRLGPGWSHSCHAMLYAPNPGMLFGRIPLRYAVLMQMRFDGLLGFPGGFVDRRYWSLEDGLNRVLGLGLGCVRLTEADYLCSHLTDGPHRVVAHLYARQLTLEELHTIEISAVHSRDHGLEVMGMVRVPLYTQKDRMGGLPNFLANSFVGTAKFQLLFALKILNMVPEEKLAEAVAATQKPKKPAIDHAAVAAAKQANELAAAARAGNEYADSGENQAAAHAAAELAEQQAAGLESQAVLEHLAAVPGAEAVVAELHAQPGADAVLEQPVAEAME
What is the function of this protein?
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin.
What are the official names of this protein?
Tudor-interacting repair regulator protein, NUDT16-like protein 1, Protein syndesmos.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. TIRR subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor; Cytoplasmic side. Cell junction, focal adhesion. Note=Colocalizes with SDC4 in ventral plasma membrane adhesion plaques.
Protein: WSS1_SCHPO
Sequence: MIAILYLYYILTTSILLSVSFMLRINDDDHPNEKIGFISAIKGDFHDLSSDYLKRIAAMAFPIMKEHGFGVTSLDEVAYNAKFWGRNWNKGECIELVLRDASNRWLPFEFVMDVFLHELCHIWQGPHDRRFFSHLSTLRAALIALYAKGYKGPGKYMTWDSFVLANVVGNYNTVVFNGITLERSTMHGVETCGGSLQRKKKIRRKPTPSSTKKRKLTRTGQKLGTDMNIRLELLKSPAKPQAQSMRGREARIAAALLRVDNSNEYKPKDHNSSTTLENYFVVE
What is the function of this protein?
Metalloendopeptidase that acts selectively on DNA-binding proteins.  DNA is needed to bring the protease and substrates together to enable proteolysis.  Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (top1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde.  Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped top1 from chromatin.  DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways.  May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites (By similarity).
What are the official names of this protein?
DNA-dependent metalloprotease WSS1 homolog, DNA damage response protein WSS1 homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family. WSS1-like metalloprotease (WLM) subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPE_GEOTN
Sequence: MKTIRVSVVTPDGPVYEGDVEMVSVKAKSGELGILPGHIPLVAPLEISAARLKKDGKTSYVAVSGGFLEVRPDKVTILAQAAERAEDIDVLRAKAAKERAERRLQSQQDDIDFKRAELALKRAMNRLNVAGMK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: I12R1_HUMAN
Sequence: MEPLVTWVVPLLFLFLLSRQGAACRTSECCFQDPPYPDADSGSASGPRDLRCYRISSDRYECSWQYEGPTAGVSHFLRCCLSSGRCCYFAAGSATRLQFSDQAGVSVLYTVTLWVESWARNQTEKSPEVTLQLYNSVKYEPPLGDIKVSKLAGQLRMEWETPDNQVGAEVQFRHRTPSSPWKLGDCGPQDDDTESCLCPLEMNVAQEFQLRRRQLGSQGSSWSKWSSPVCVPPENPPQPQVRFSVEQLGQDGRRRLTLKEQPTQLELPEGCQGLAPGTEVTYRLQLHMLSCPCKAKATRTLHLGKMPYLSGAAYNVAVISSNQFGPGLNQTWHIPADTHTEPVALNISVGTNGTTMYWPARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPDPAGMATYSWSRESGAMGQEKCYYITIFASAHPEKLTLWSTVLSTYHFGGNASAAGTPHHVSVKNHSLDSVSVDWAPSLLSTCPGVLKEYVVRCRDEDSKQVSEHPVQPTETQVTLSGLRAGVAYTVQVRADTAWLRGVWSQPQRFSIEVQVSDWLIFFASLGSFLSILLVGVLGYLGLNRAARHLCPPLPTPCASSAIEFPGGKETWQWINPVDFQEEASLQEALVVEMSWDKGERTEPLEKTELPEGAPELALDTELSLEDGDRCKAKM
What is the function of this protein?
Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction.  Associated with IL12RB2 it forms a functional, high affinity receptor for IL12.  Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
What are the official names of this protein?
Interleukin-12 receptor subunit beta-1, IL-12 receptor subunit beta-1, IL-12R subunit beta-1, IL-12R-beta-1, IL-12RB1, IL-12 receptor beta component.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 2 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.