PharMolix/UniProtQA huggingface dataset:
Protein: IER5L_RAT
Sequence: MECALDAQSLISISLRKIHSSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQQQQQQQQQQPPHHQHQHLAYAAPGMPASAADFGPLQLGGGGDAEAREPVARHQLHQLHQLHQLHLQQQLHQHQHPAPRGCTAAAPVAVAGAPAGCAGALSELPGCAALQPPHGAPHRGQHLEPLQPGPAPLPPPAPAALCPRDPRVPAACSAPSAPPGAAPPTVAASSPPASPAPSSSPGFYRGAYPAPSDFGVHCSSQTTVLDLDTHVVTTVENGYLHQDCCASAHCPCCGQGAPGPGLASAAGCKRKYYPGQEEEDDEEEDAGDLGAEPPGGTPFAPCKRARFEDFCPDSSPDASNISNLISIFGSGFSGLVSRQPDSSEQPPPLNGQLCAKQALASLGAWTRAIVAF
What are the official names of this protein?
Immediate early response gene 5-like protein.
What is the protein family that this protein belongs to?
Belongs to the IER family.
Protein: ERA_CLOBJ
Sequence: MFKSGFVTIVGRPNVGKSTLLNAIMKEKLSIVSCRPQTTRNNIQTILTEDNYQLVFVDTPGIHKPKHKLGEYMVKSASDAMKDVDLVLFLINPDEKPGRGDLFIIEQLKEVKVPVFLVLNKIDENPQEKVAETLKTYSELMEFQEIIPISALKGKNVDLLKELMFKYIPEGPQYYPEDMIIDQNERFIVAEIVREKALRLLSEEVPHGIAVEILQMKKNEKGTYHIEGNILCEKNSHKPIIIGKGGSKLKKISQYARQDIEAFLQSKVYIRLWVKVKEEWRDNQSLLKELGYKKMK
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: IF1_HAEIG
Sequence: MAKEDCIEMQGTILETLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVEMTPYDLSKGRIIFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y737_PROMM
Sequence: MTSSTDSNLTLIPSPGDKVEITCLDLDRHGNGLARWNNWVVIVNDLLPGESAQIEFVRRHRNQFLARKVQTIETVASRRPPPCKIAKECGGCSIQHLSDHGQTLLKQGHLRQILLRLGQLDHKIEPIMTDYNRALGYRNRALIPLYRNSEGQLHMGYYRRGSHQIIDLNRCPVLDRGIDQYLASIKDDLQQQNWPADSDLSSGEGLRHLGIRIGQKTKQVLITLVSSTTQLSGLHQQAKEWYSRWPEVRGITLNIQRQRNNLVLGQETILLAGDLEIEEHFYNLSLLLSTTTFFQVNTLQAERIVSKLIEWLSTASLDINIIDAYCGIGTISLPIAATGYHVIGLELHAEAITQANKNALRNSLDNVSFLCGDVSLLLAKKLQRNDVLVLDPPRKGLDQMVIKTILSIQPERVAYLSCDPATLARDLKQLIVPNGPYQIDELQPIDFFPQTMHIECLALLTRISS
What are the official names of this protein?
Uncharacterized RNA methyltransferase PMT_0737.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: RENBP_RAT
Sequence: MEKERETLQVWKQRVGQELDSVIAFWMEHSHDQEHGGFFTCLGRDGQVYDHLKYVWLQGRQVWMYCRLYRTFERFRRVELLDAAKAGGEFLLSYARVAPPGKKCAFVLTQDGRPVKVQRTIFSECFYTMAMNELWKVTGEMHYQREAVEMMDQIIHWVREDPAGLGRPQLSGTLATEPMAVPMMLLNLVEQLGEEDEEMTDKYAELGDWCAHRILQHVQRDGQVVLENVSEDGKELPGCLGRHQNPGHTLEAGWFLLQYALRKGDPKLQRHIIDKFLLLPFHSGWDPEHGGLFYFQDADDLCPTQLEWNMKLWWPHTEAMIAFLMGYRDSGDPALLNLFYQVAEYTFHQFRDPEYGEWFGYLNQEGKVALTIKGGPFKGCFHVPRCLAMCEQILGALLQRLGPAPLGSLPAVPTREGSK
What is the function of this protein?
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine.  Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
What are the official names of this protein?
N-acylglucosamine 2-epimerase, AGE, GlcNAc 2-epimerase, N-acetyl-D-glucosamine 2-epimerase, Renin-binding protein, RnBP.
What is the protein family that this protein belongs to?
Belongs to the N-acylglucosamine 2-epimerase family.
Protein: KPB2_TAKRU
Sequence: MRSRSNSGVRLDGYARLVHETILGFQNPVTGLLPASVQKKDAWVRDNVYSILAVWGLGMAYRKNADRDEDKAKAYELEQSVVKLMQGLLHCMMRQVAKVEKFKHTQSTTDCLHAKYDTSTCATVVGDDQWGHLQVDATSIYLLMLAQMTASGLRIISNLDEVAFVQNLVFYIEAAYKVADYGMWERGDKTNQGLPELNGSSVGMAKAALEAIDELDLFGAHGGPKSVIHVLPDEVEHCQSILCSMLPRASPSKEIDAGLLSVISFPAFAVEDADLVTITKSEIINKLQGRYGCCRFIRDGYHCPKEDPTRLHYDPAELKLFENIECEWPVFWTYLILDGIFAEDQVQVQEYREALEGVLIRGKNGIKLLPELYTVPFDKVEEEYRNPHSVDREATGQLPHMWEQSLYILGCLLAEGFLAPGEIDPLNRRFSTSFKPDVVVQVCVLAESQEIKALLSEQGMVVQTVAEVLPIRVMSARVLSQIYVRLGNCKKLSLSGRPYRHIGVLGTSKFYEIRNHTYTFTPQFLDQHHFYLALDNQMIVEMLRTELAYLSSCWRMTGRPTLTFPVTRSMLVEDGDAVDPCILSTLRKLQDGYFAGARVQMSDLSTFQTTSFHTRLSFLDEEHDDSLLEDDEEQEEEEEDKFEDDYNNYGPSGNNQVCYVSKDKFDQYLTQLLHSTTQKCHLPPIQRGQHHVFSAEHTTRDILSFMAQVQGLNVPKSSMYLPVTPLKSKHRRSLNLLDVPHPQHGPHLKQNKVGTFNSVLAADLHLPRDPQGKTDFATLVKQLKECPTLQDQADILYILNTSKGADWLVELSGPGQGGVSVHTLLEELYIQAGACKEWGLIRYISGILRKRVEVLAEACTDLISHHKQLTVGLPPEPRERVITVPLPPEELNTLIYEASGQDISVAVLTQEIMVYLAMYIRSQPALFGDMLRLRIGLIMQVMATELARSLHCSGEEASESLMSLSPFDMKNLLHHILSGKEFGVERSMRPIQSTATSPAISIHEIGHTGATKTERTGIRKLKSEIKQRCSSPSTPSGILSPVGPGPADGQLHWVERQGQWLRRRRLDGAINRVPVGFYQKVWKILQKCHGLSIDGYVLPSSTTREMTAGEIKFAVQVESVLNHVPQPEYRQLLVESVMVLGLVADVDVESIGSIIYVDRILHLANDLFLTDQKSYSAGDYFLEKDPETGICNFFYDSAPSGIYGTMTYLSKAAVTYIQDFLPSSSCIMQ
What is the function of this protein?
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.  The alpha chain may bind calmodulin (By similarity).
What are the official names of this protein?
Phosphorylase b kinase regulatory subunit alpha, liver isoform, Phosphorylase kinase alpha L subunit.
What is the protein family that this protein belongs to?
Belongs to the phosphorylase b kinase regulatory chain family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: HSP7A_ENCCU
Sequence: MLVRGLLSAVATIFCGAPKDTDLRESVAVGIDLGTTYSCISVYSPSSKDTRFVLSPGGEETYPSVVYFKKLPEGDGKKSKYEAVAGWPGLQMYNAEGNANTYFYAFKRGMGIEDLANIDKKVEEIKRNASVPIFVESVGGKKRVAYKIQEAMQDGYESVTPEELSSHVLRMLKDQIVKDYKIQGLTITVPAYFDVNQVAATIKAAEMAGFPTPIIWKEPSAAAFAHTYDLIRKGITTKEEVDDMNICVFDLGGGTFDVSIVESSGGFMMVPSYGGNNFLGGENVNDNLTKYFADYIKSSTGFDVMENQNVKLRLRNVVEDMKRDLCDEVRKSPGRKANPSISKSFIYDGEKSIVLELTNEKFNELNADFYSRIRKTMDSLLSGDGKDNKGYDKSLINRVLLVGGSTRIPKVIDIVEEIFGANKIYSEGVNADTIVARGAALYTANSLNLLNESEQIVTADSVPLSLGICTEEDHFEAIISKGALLPATGTKEFTTAQDNQTKVRIRVAQGGLESFKDNIYIGDIELDLPGNQPRGVPRIAVTLEIDTHGKIYVKAVDLQNNKEASSYFSSVVANMTSEEIERFEERVHGEENQELVKKREVVRKLEQAISQAESPKFAEVIPENIKKDALEYVQKTRLWLEKHKEIAPRIHIEEKLQEFDNGMKEFLSSAKSGEEKEIGREEL
What are the official names of this protein?
Heat shock protein ECU02_0100.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_HELP2
Sequence: MPKKCRHLLQTSDLSLDEIKLLLNKASVYANDFNAVSLETKEKMHNKIIVALFFENSTRTVSSFEIASLRLGAKIVKLNMQTSSTSKGETLIDTFKNIHAMQPDAIITRHAFSSTPFKLAEFSQCPLINAGSGTSAHPTQALLDLLTLYQHFGGLENLKGKKIAFIGDVKNSRVANSNIKLLQRLGLEIMLCAPSSMLPSTPLRTTHNIEEAIEFADILMSLRTQTERHNAPIFASLKDYGNAYCITQQRLKAHAKNKEVVILHPGPVHRDIDIESAVLEDKRSKVLEQVKNGVAMRMAVLEFLLLD
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: SYK_STAAN
Sequence: MSEEMNDQMLVRRQKLQELYDLGIDPFGSKFDRSGLSSDLKEEWDQYSKEELVEKEADSHVAIAGRLMTKRGKGKAGFAHVQDLAGQIQIYVRKDQVGDDEFDLWKNADLGDIVGVEGVMFKTNTGELSVKAKKFTLLTKSLRPLPDKFHGLQDIEQRYRQRYLDLITNEDSTRTFINRSKIIQEMRNYLNNKGFLEVETPMMHQIAGGAAARPFVTHHNALDATLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYHDIMDLTESMVRHIANEVLGSAKVQYNGETIDLESAWTRLHIVDAVKEATGVDFYEVKSDEEAKALAKEHGIEIKDTMKYGHILNEFFEQKVEETLIQPTFIYGHPTEISPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQKGRFEAQLVEKAQGNDEAHEMDEDYIEALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVLLFPYMRQK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_STRU0
Sequence: MKIKIICVGKIKEKYLKDGIAEYQKRLSRFTQFEIIELADEKTPEKASQAENEKIMEKEANRILSKIGNRDYVIALAIEGKQYASEEFSQFITDITIQGFSDITFIIGGSLGLHSKIKQKAHALISFGRLTLPHQLMRLVLTEQIYRAFMIQEGSPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_ECOLI
Sequence: MTLTASSSSRAVTNSPVVVALDYHNRDDALAFVDKIDPRDCRLKVGKEMFTLFGPQFVRELQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAAREALVPFGKDAPLLIAVTVLTSMEASDLVDLGMTLSPADYAERLAALTQKCGLDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQGSEAGDQRRIMTPEQALSAGVDYMVIGRPVTQSVDPAQTLKAINASLQRSA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RS15_BORBR
Sequence: MSVADIKKSEIVAQFQRAQGDTGSPEVQVALLTARINELTGHFKEHMKDHHSRRGLLRMVSRRRKLLDYLKGRNPDSYRALIEKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: QUEF_BACMK
Sequence: MAGRLDEDLKDVTLLGNQNTKYLFEYSPEILEVFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEQRMVESKSLKLYLFSFRNHGDFHEDCMNVIMNDLIKLMDPRYIEVWGKFTPRGGISIDPYCNYGRPGTKYEKMADYRMMNHDLYPEKIDNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JIP5_PICGU
Sequence: MAKKAKKDGRSVEPTGNPILEVKYNDPLFSIAAHPTEPIFVSGLATGHVFCNRYDAERLEERMQAIKDEQKKKSKTSVKTTNAAWWTQVEDITNTDEIVTCWKTKRHKGSCRSVLFDPIESSVGKHLFTVGKDHVVKKANTETGKVLTKTDISKDLSSKDAVTKLCHSTTHPFLLSGTENGHVLVYDSNDLSNKFKVENVHEDAVNHILAMPSVSPYHYLTVGSTTLSHIDIRKGIVTQSDDQEDELLSMSFVPDDDRNDTVLVSHGGGIVTIWKNSKNKLMDQLSRIKVNKEASIDVMISAMDAGDDDMAASVWCGDSDGLVHRVNYKKGKVVETRLHGTADEVGFLDIDYEYRLLTAGMDSMKLWSAEGDDEEEEESEGEESEESEESDEESDESSGEESEGDDGNGSNSEESDSNDEDEVESSDDEKEKEEESTETDHKNIEAESGKQANKRQASQPKSAGENVKKQKLKQTSKLAHSHGIRRFDGL
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ATP6_ANADE
Sequence: MTAATLVTLALSLSLAQHDAAPAPVAAPVEQHGQAPEAAPDAHGSPAGEPGAAVEAHAAAAEHGEAAGHEGGHDESLGAVMLHHVTDGYVIEHPGLCHGGLAWNCEWDLRETFGDSLKFGKLDMTPTKHVVMMWLASALLLVVVLGAVRKKSLVPRGLYNFIELLVAFVRNEIAVKNMGEKDADRFTPYLVTAFFFILFLNLFGLLPFSATATANLSVTVAMALFTFVITQYAAIRAMGMGGYLAHLTGGVPKSLAPLWLIMIPVEFLGLFTKPFALTVRLFANMLAGHFVILALLGLIFALGTPWVAFGSVPMALSIFLLELFVAFVQAYIFTMLSSLFIGAGLVHHGDDHGHAEEHGHAGPAAGSEHGSHVAGASPGHG
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: H2AZ_CRYNJ
Sequence: MSSKVGGGKGGKSKTSSEAKVLTTRSSKAGLQFPVGRIHRFLRNKNANNVRIGAKAAVYVASIMEYLTAEVLELAGNAAKDLRVKRITPRHLQLAIRGDEELDLLIRATIAGGGVLPHIHKSLVAKNAPLKKPKALDA
What is the function of this protein?
Variant histone H2A which can replace H2A in some nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received.  Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins.  Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Histone H2A.Z.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: EFTU_PARL1
Sequence: MAKEKFERNKPHCNIGTIGHVDHGKTSLTAAITKVLAETGGATYSAYDQIDKAPEEKARGITISTAHVEYQTEARHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPALVVFMNKVDQVDDPELLELVEMEIRELLSSYDFPGDDIPIVKGSALAALEDSNKEIGHDAILELMKAVDAYIPQPERPKNLPFLMPIEDVFSISGRGTVVTGRIERGVVKVGEEIEIVGIKPTVKTTCTGVEMFRKLLDQGEAGDNVGVLLRGTKREDVERGQVLCAPGSITPHTEFEAEAYILTKEEGGRHTPFFTNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNVKMNVTLIAPIAMEEKLRFAIREGGRTVGAGVVSKVLK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAD11_MOUSE
Sequence: MKENYCLQAALVCLSMLYHSQAFALERRSHLHPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHEIYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGIELFEITTDYETQDGVVKLKKPVDFETKRAYSLKIEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNISVFAAEIHNRHQETKVPVAIRVLDVNDNAPKFAAPYEGFICESDHPKALSNQPIVTVSADDQDDTANGPRFIFSLPPEIMHNPNFTVRDNRDNTAGVYARRGGFSRQKQDFYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS
What is the function of this protein?
Cadherins are calcium-dependent cell adhesion proteins.  They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.  Required for proper focal adhesion assembly.  Involved in the regulation of cell migration.
What are the official names of this protein?
Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RN146_AILME
Sequence: MAGCGEIDHSVNMLPTNRKANESCANPAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKSTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCEANTVNLARESSADGADSVSAQSGASSVQPLVSSLRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPAPDTSVEETESDASSDSEDVSALVAQHSLTQQRLLVPNANQTVSDRSDRSGIDRSVAGGGTVNAGVRSRRPDGQCTVTEV
What is the function of this protein?
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation.  May regulate many important biological processes, such as cell survival and DNA damage response.  Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex.  Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2.  Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation.  Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'.  May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location.  Neuroprotective protein (By similarity).  Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity).  Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity).  Does not affect PARP1 activation.  Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity).  Promotes cell survival after gamma-irradiation.  Facilitates DNA repair (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF146, Iduna, RING finger protein 146, RING-type E3 ubiquitin transferase RNF146.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.
Protein: YD129_YEAST
Sequence: MELRSRRSAEAYLVTPEEPAKNKSERSIESNERVGTREAKSENTSVFSPAYSDTATTDSSKKVDDNEYYNFTSHFMPSLKNTRELENTILNLIQRIKEGDDETLVSEKDLILSVLNRSLASTSHWKLQAQLSELRATSEGRYAVETNLLKKEVEFLKNKTPKTNESASSAELRPLLERPLKRKLSLPGLAQRPLSTGARLEGGYGGVSPNSWKTKVPKLPLPASRPSLNLSPQKVPTGTDKVEEDTKIDTLELVENNKPHPRMRRRSDNPATNEYVRVFHLEKKEPKSRKK
What are the official names of this protein?
Uncharacterized protein YDL129W.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ADDA_STRPQ
Sequence: MLFNINEKGEPLVISFAPFLSPEAIKHLQENERYSDQSQKRTAQQIEAIYTSGQNILVSASAGSGKTFVMVERILDKILRGVSIDRLFISTFTVKAATELRERIENKLYSQIAQTTDFQMKVYLTEQLQSLCQADIGTMDAFAQKVVSRYGYSIGISSQFRIMQDKAEQDVLKQEVFSKLFSEFMNQKEAPAFRALVKNFSGNCKDTSAFRELVYTCYSFSQSTENPKIWLQENFLSAAKTYQRLEDIPDHDIELLLLAMQDTANQLRDVTDMEDYGQLTKAGSRSAKYTKHLTIIEKLSDWVRDFKCLYGKAGLDRLIRDVTDLIPSGNDVTVSKVKYPVFKTLHQKLKQFRHLETILMYQKDCFPLLEQLQDFVFAFSEAYLAVKIQESAFEFSDIAHFAIKILEENTDIRQSYQQHYHEVMVDEYQDNNHMQERLLTLLSNGHNRFMVGDIKQSIYRFRQADPQIFNQKFRDYQKKPEQGKVILLKENFRSQSEVLNVSNAVFSHLMDESVGDVLYDEQHQLIAGSHAQTVPYLDRRAQLLLYNSDKDDGNAPSDSEGISFSEVTIVAKEIIKLHNDKGVPFEDITLLVSSRTRNDIISHTFNQYGIPIVTDGGQQNYLKSVEVMVMLDTLRTINNPRNDYALVALLRSPMFAFDEDDLARIALQKDNELDKDCLYDKMQRAVIGRGAHPELIHDTLLGKLNVFLKTLKSWRRYAKLGSLYDLIWKIFNDRFYFDFVASQAKAEQAQANLYALALRANQFEKSGYKGLYRFIKMIDKVLETQNDLADVEVAAPKQAVNLMTIHKSKGLQFPYVFILNCDKRFSMTDIHKSFILNRQHGIGIKYLADIKGLLGETTLNSVKVSMETLPYQLNKQELRLATLSEQMRLLYVAMTRAEKKVYFIGKASKSKSQEITDPKKLGKLLPLALREQLLTFQDWLLAIADIFSTEDLYFDVRFIEDSDLTQESVGRLQTPQLLNPDDLKDNRQSETIARALDMLEAVSQLNANYEAAIHLPTVRTPSQLKAAYEPLLEPIGVDIIEKSSRSLSDFTLPHFSKKAKVEASHIGSALHQLMQVLPLSKPINQQTLLDALRGIDSNEEVKTALDLKKIESFFCDTSLGQFFQTYQKHLYREAPFAILKVDPISQEEYVLRGIIDAYFLFDDHIVLVDYKTDKYKQPIELKKRYQQQLELYAEALTQTYKLPVTKRYLVLMGGGKPEIVEV
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: RL28_AERHH
Sequence: MSRVCQVTGKRPAVGNNRSHANNATKRRFLPNLHTHRFWVESEKRFVSLRVSAKGMRIIDKRGVEVVLAELRASGVKV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: MURG_YERPP
Sequence: MSGKTKRLMVMAAGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEASLVPQHGIEIDFIKISGLRGKGLMAQLTAPIRIYRAVRQAQKIMRDYQPNVVLGMGGYVSGPGGLAAWLCGVPVVLHEQNGIAGLTNRWLARIAKKVLQAFPGAFPNADVVGNPVRTDVLALPLPAVRLSGREGPIRVLVIGGSQGARILNQTLPLVAASLGEQITLWHQVGKGALPEVSQAYQQAGQAGHLVVEFIDDMAAAYAWADVVVCRSGALTVSEVAAAGLPAIFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQFTATSVSSLLASWDRATLLSMAERARSVAIPDATERVAAEVVAASKSA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RMD9_YEAST
Sequence: MMLRRNAVRSLKTMEISVSNVVNSGSIAMLRGKLANVVLSDRTYHSSPIFHKNVPKGVLDKKNGREQRKTEQNVFNVDPASPWRHELLSFDECVSSALKYSTTPLQNTYKRIGNNQLNKNPSFAMFWDSMGRAMELYYSLRESPDFNAYRVSRLIHLLHNGLRSTRDQLVKLSRKPDYDSQSFHKEMMNFLCNSLKDISDDILIGKVSVSGYGATHLLTSFKELSFDDDCIRIWEASKNLSDETTSQAFQEPKVVGFMLPLLYAKTRSLTEPNELYNQIIQSKEFIHPNLYSGLIKVFIKAEDYEKALSLFGQLCEKAEVRNYGYLIETHLSFIGDSKNLTLAESFFDKIINDEMPYKIILQVSTVNSFLQNIWKAQNDFDHVYRIWEKAVKFYGNTVNPGILSSLNNTFFTIFFENYINDNINGFRKLQEIITFYSGVKKIDEPFFNVMLTRASIWHERSIIDFIDKNYTLYHIPRTIISYRILLKSLGSIDNTNNEEILDRWLELVKKLNELGQQYIANADLSALRDATVVWSQSKRDEKVFSAKAKGTPATTTTTEDDIKVPKPLENLKNEDSTSNSEDRIELYLKILKRYTPYFRATKQVYRYTTGCAESYPILNEYLSGYSDLSAEDIPVPQLHSFIAKEQ
What is the function of this protein?
Binds the RNA motif 5'-AAUAA[U/C]AUUCUU-3' in the 3'-UTR of mitochondrial mRNAs (PubMed:33876744, PubMed:10441495, PubMed:10905425).  Involved in the processing or stability of mitochondrial mRNAs (PubMed:33876744, PubMed:17194787, PubMed:17194786).
What are the official names of this protein?
RNA-binding protein RMD9, mitochondrial, Dodecamer binding protein, DBP, Required for meiotic nuclear division protein 9.
What is the protein family that this protein belongs to?
Belongs to the RMD9 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.