PharMolix/UniProtQA huggingface dataset:
Protein: XGPT_ERWT9
Sequence: MSEKYVVTWDMLQIHARKLAARLLPAEQWKGIIAVSRGGLVPAALLARELCIRHVDTVCISSYDHDNQREMSVLKRAEGDGEGFIVIDDLVDTGGTAQAIRDMYPKAHFVTIFAKPAGRPLVDDYIIDIPQNTWIEQPWDMGIAYIPPLVKS
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PYRH_MYCBO
Sequence: MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_RHIWR
Sequence: MTAQIIIAVPKGRILKEVLPLFAALGIVPEPAFGDEDSRLLRFATNRSDIGLIRVRAFDVATFVAHGAAQLGIVGSDVLMEFDYSELYAPVDLAIGHCRISVAEPVAMAAGDDPREWSHVRVATKYPNITRRHFEARGVQAECVKLNGAMEIAPVLGLSSRIVDLVSTGRTLKDNGLAEVETIAEVSSRLIVNRAAFKTRAGEIGPLVEGFRRAVEDKNAA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3A_SULIM
Sequence: MSAKGGTIKDKWKMKKWYSIIAPKVFGEVSLGSTPAYDVTQTIGRRVETTLYDLTGDFSQVYVHLYFKIVSNEGDRLITRFVGHELSRDYLRSLIRRKSSKVNSVFDVTTKDGYVVRVKGLVLTTYKCHQSQKTAIRKIINETISKKASELTFDDFTQEVVFGRLANEIFEATKKIYPLRKAEIEKTKVLKVPENLGKQVESSSVSSG
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: COBQ_SHEAM
Sequence: MIQGTASDAGKTTLVAGLCRLLARQGLKVAPFKPQNMALNSAVTEDGGEIGRAQALQAAACGLKPHTDFNPILLKPGSDTRAQVIVHGKALTSLEASAFFGPEGKGYKAIAIEAVLESYNRLKQSFDYLLVEGAGSPAEINLRENDIANMGFAEAVDCPVILVADIDKGGVFAQLVGTLALLSESEQARIKGFVINRFRGDINLLQPGLDWLEAHTGKPVLGVVPYLHNLLLDAEDALVPYQQAGADSGARFRVRVLVYPRTSNHTDFDPLRLHPGVDFDYLDIQHASPDALQGADLVILPGSKNVRADLECLKTKGFDCALRKHVRYGGKLVGICGGYQMLGIEIDDPDGVEDTPGSSDALEFLPLITELEGSKVLANVSGELSLGEEAVAVKGYEIHCGRTTVLGQLSRPLFLVDDTGNPASDRGCISDDGAIFGCYLHGIFDTPAALDAVLAWAGYRGAARGTSLEEHREQQLERLADTLAEHLDMARLNSLF
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: COXX_BURTA
Sequence: MDTTLSHTPGSRLSQYLALTKPRVTQLAVFCAVIGMFLATPGMVPWKVLLGGTVGIGLLAGSAFAINCLVEQKIDAMMRRTAWRPSARGEITTLQILAFSTVLGGLGAWTLYTFTNPLTMWLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALGWAAVTGAVPGDAWILVLIIFVWTPPHFWVLALYRRKDYENAGLPMLPVTHGEQFTRLHILLYTVILFAVTMMPFISGMSGAVYLTSAVLLGAIFLAYAWKIYRDYSDALARRAFRYSIVYLSLLFAALLVDHYARPVIGM
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: G3P_CRYNJ
Sequence: MVVKVGINGFGRIGRIVLRNAIEHGDLEVVAVNDPFIDLDYMVYMFKYDSTHGRFKGSVEVKDGKLYINNKAIAVFGEKDPANIKWGEAGAEYVVESTGVFTTTEKAGVHLKGGAKKVVISAPSADAPMFVCGVNLDAYKPEYQIVSNASCTTNCLAPLAKVIHDNFTIIEGLMTTVHATTATQKTVDGPSHKDWRGGRGAAANIIPSSTGAAKAVGKVIPSLNGKLTGMSFRVPTSDVSVVDLVCRIEKGASYEEIKNVIKKASESPELKGILGYTEDAVVSTDFIGSTESSIFDAQAGIALNANFVKLVSWYDNEYGYSRRVCDLISYIAGVDAKAQ
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLPL5_MOUSE
Sequence: MDFLEAEGGWNLSFSGSGYMGLYHVGVTQCLRQRAPRLIQGARRFYGSSSGALNAMAIVFGKSADFACSNLLDLVKLVERLSLGIFHPAYGPAEHIRKKLYENLPDNCHILASQRLGISMTRWPDGKNFIVTDFATRDEFIQALICTLYLPLYCGVIPPAFRGQRFIDGALSNNLPFSDCPTTITVSPFNGTVDICPQNISHSLFELTAFNASFQISTRNFFRGLKSVFPPKPEVVADHCRQGYLDALRFLERRGLTKEPVLWSLVSKEPPALVEGPRGTGHDQGQKTGPTVRWDIPNVLVKDVPNFELLSPELEAALRKACKRDFWTRVQCSVPGKVLAYLLLPCTLPFEYAYFRSRRLMEWLPEAPDDLDWMRSILKSTTLEVYSMAKSWLLRLGSPPGTRADSGLLRQQRGTAPSGNRPLNHRWFPGMD
What is the function of this protein?
Has abundant triacylglycerol lipase activity.
What are the official names of this protein?
Patatin-like phospholipase domain-containing protein 5.
Protein: RS9_GEOSW
Sequence: MAQVQYYGTGRRKSSVARVRLVPGDGRIVINDRDIRDYIPSEALIEVVKQPLVLTETLGNYDVLVNVKGGGFSGQAGAIRHGIARALLQVDPDYRPVLKRAGLLTRDARVKERKKYGLKGARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: TENA_STAAC
Sequence: MEFSQKLYQAAKPIINDIYEDDFIQKMLSGDIGADALRHYLKADAAYLKEFTNLYALLIPKMNSMNDVKFLVEQIEFMVEGEVLAHDILAQIVGESYEEIIKTKVWPPSGDHYIKHMYFQAHSRENAIYTIAAMAPCPYIYAELAKRSQSDHKLNREKDTAKWFDFYSTEMDDIINVFEALMNKLAESMSDKELEQVKQVFLESCIHERRFFNMAMTLEQWEFGGKVND
What is the function of this protein?
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.  Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP).  Is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity may not be physiologically relevant.  Therefore, is probably involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the environment, rather than in thiamine degradation.
What are the official names of this protein?
Aminopyrimidine aminohydrolase, Thiaminase II.
What is the protein family that this protein belongs to?
Belongs to the TenA family.
Protein: RR8_COFAR
Sequence: MGRDTVAEIITSIRNADMDKKRVVRITSTNITENIVKILLREGFIENARKHRENNKYFLVLTLRHRRNRKGPHRNIFNLKRISRPGLRIYANSQRIPRILGGMGIVIFSTSRGIMTDREARLEGIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LRK44_ARATH
Sequence: MFFIKLFTIFFLSFFWQSLKSSSQIIDFTYNGFRPPPTDISILGIATITPNGLLKLTNTTMQSTGHAFYTKPIRFKDSPNGTVSSFSTTFVFAIHSQIPIAHGMAFVIAPNPRLPFGSPLQYLGLFNVTNNGNVRNHVFAVELDTIMNIEFNDTNNNHVGIDINSLNSVKSSPAGYWDENDQFHNLTLISSKRMQVWVDFDGPTHLIDVTMAPFGEVKPRKPLVSIVRDLSSVLLQDMFVGFSSATGNIVSEIFVLGWSFGVNGEAQPLALSKLPRLPVWDLKPTRVYRFYKNWVPLISLLLIPFLLIIFLVRFIMKRRRKFAEEVEDWETEFGKNRLRFKDLYYATKGFKDKNILGSGGFGSVYKGIMPKTKKEIAVKRVSNESRQGLKEFVAEIVSIGQMSHRNLVPLVGYCRRRDELLLVYDYMPNGSLDKYLYNSPEVTLDWKQRFKVINGVASALFYLHEEWEQVVIHRDVKASNVLLDAELNGRLGDFGLAQLCDHGSDPQTTRVVGTWGYLAPDHIRTGRATTTTDVFAFGVLLLEVACGRRPIEINNQSGERVVLVDWVFRFWMEANILDAKDPNLGSEYDQKEVEMVLKLGLLCSHSDPLARPTMRQVLQYLRGDAMLPDLSPLDLRGSGIMLGTHNGSNESGMFTSGSSVAYSLLSSGR
What is the function of this protein?
Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae.
What are the official names of this protein?
L-type lectin-domain containing receptor kinase IV.4, LecRK-IV.4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ARCA_ECO7I
Sequence: MMEKHYVGSEIGQLRSVMLHRPNLSLKRLTPSNCQELLFDDVLSVERAGEEHDIFANTLRQQGIEVLLLTDLLTQTLDIPEAKSWLLETQISDYRLGPTFATDVRTWLAEMSHRDLARHLSGGLTYSEIPASIKNMVVDTHDINDFIMKPLPNHLFTRDTSCWIYNGVSINPMAKPARQRETNNLRAIYRWHPQFAGGEFIKYFGDENINYDHATLEGGDVLVIGRGAVLIGMSERTTPQGIEFLAQALFKHRQAERVIAVELPKHRSCMHLDTVMTHIDIDTFSVYPEVVRPDVNCWTLTPDGHGGLKRTQESTLLHAIEKALGIDQVRLITTGGDAFEAEREQWNDANNVLTLRPGVVVGYERNIWTNEKYDKAGITVLPIPGDELGRGRGGARCMSCPLHRDGI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GI_CHV9D
Sequence: MLLWYTTASIMRYLMVFMLFGIQCAAAIIYRGNYISLYVNSSATSIFLKGNNNDASIRGRFLFIGDQFPVTNTYNVTVELLHVNQTTLCLQPLYRVMYGECPRIRTGAIIACRVKRSWHYENATQLTDPNVEIIFKMNNTKVEDAGIYLLVVQLDYTSLFDIFFVSLNVYPKQDTSNEDVNYFPPVYSPSHILNTFKICHKFPVHNGMEQSILQHIVTSDVDTETENLSWQKDDLGSTQKPRKNFNPDVKVNVTHETRKTLMESSADVFMIAVPITASLLVILAIIIVVTVGIYRRRSSEKRKIYRPKRTKEQASTEKRERSESDVLLEAAVARLETIQEENPPHSVINPFTK
What is the function of this protein?
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions.  Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions.  Implicated in basolateral spread in polarized cells.  In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system.  Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.
What are the official names of this protein?
Envelope glycoprotein I, Membrane glycoprotein 1.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein I family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). The heterodimer gE/gI then redistribute to cell junctions to promote cell-cell spread later in the infection (By similarity).
Protein: FLIT_YERPN
Sequence: MERHQHLLSEYQQILTLSEQMLMLATVENWNALVDLEMTYLKAVENTANITISSCTSPVLQELLRQKLRSILENEIEIKRLLQRRLDKLSELVGQSTRQQAVNRTYGQFPDQALLLGETQ
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: BEV1D_BETPN
Sequence: MGVFNYEIETTSVIPAARLFKAFILDGDNLVPKVAPQAISSVENIEGNGGPGTIKKINFPEGFPFKYVKDRVDEVDHTNFKYNYSVIEGGPVGDTLEKISNEIKIVATPDGGCVLKISNKYHTKGNHEVKAEQVKASKEMGETLLRAVESYLLAHSDAYN
What is the function of this protein?
May be a general steroid carrier protein.
What are the official names of this protein?
Major pollen allergen Bet v 1-D/H, Allergen Bet v I-D/H.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDX1_DICDI
Sequence: MSAFEDLGVLPEIIKAIEELDWLLPTPIQTEAIPLILGGGDVLAAAETGSGKTGAFALPILQITYETLNKKAEIPIIAPTNTSGEDGTSGGGGGGGGGDTIELDQIDRDKNMAVDGLICQSRSSDWCGIKATKGISSGKFYYESIVRDEGLCRIGFALKKSSRNIGTDKFSWGYGGTGKKSHESKFIDYGKPFGNNDVIGCYINFDEEIIGFTKNGQDFGEAFTFNSKAGIFYPALVLKNAEMEFNFGSKPMKHDLKGYKPINQAELLIDQQTSTQIDNSKNNNNNNNKKGSGNNKKNKGKDDDKMNDEDNNNKQPRKTLSLIIEPTRELADQAYSAILNFSKYLDSPKIQVSLCIGGEKSNGGRNKIEGDIIIGTPGRLESLVKEGSIDLSSIKFFVLDEADQLIDDNLAIVNFIYNKLPIGQNLQVLFFSATLHSTKVIKFCEQITKNPTWVDLKGRDFIPDLITHAYVKADPIKFESLWRNSENPLRIRTDGVHASDVQQFGKLKEPEQKSEAIKLLKAQLLLKCIQSFKMDQAIIFARTRLDCDHIHQFLKDAGGGNTSGLEGEFSSTVLHGGDNISRARKDNLEKFRNGDVRFLICTDVAARGIDIRGLPYMINYTLPESFEDYIHRVGRVGRSDRIGLAISLVAYEQEKVWYHTCRDKGKGCHNTKLTENGGCCIWYDEPQLFTAIQENIGPIELDSDFQLPKDMKQLNFGGSTKLTGASADYKPHTEELRSRVLQLSQLEETIQIDYLTLPKRIIKLK
What is the function of this protein?
Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes.  Possesses 5' single-stranded RNA overhang nuclease activity (By similarity).
What are the official names of this protein?
Probable ATP-dependent RNA helicase ddx1, DEAD box protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX1 subfamily.
Protein: SOTB_ECO27
Sequence: MTTNTVSRKVAWLRVVTLAVAAFIFNTTEFVPVGLLSDIAHSFHMQTAQVGIMLTIYAWVVALMSLPFMLMTSQVERRKLLICLFVVFIASHVLSFLSWSFTVLVISRIGVAFAHAIFWSITASLAIRMAPAGKRAQALSLIATGTALAMVLGLPLGRIVGQYFGWRMTFFAIGIGALITLLCLIKLLPLLPSEHSGSLKSLPLLFRRPALMSIYLLTVVVVTAHYTAYSYIEPFVQNIAGFSANFATALLLLLGGAGIIGSVIFGKLGNQYASALVSTAIALLLVCLALLLPAANSEIHLGVLSIFWGIAMMIIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSMIGYVGAVPAFAALIWSIIIFRRWPVTLEEQTQ
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MDTG_PROMH
Sequence: MNLKPRNNSWKQNLYIVWFGCFLTGAGFSLIMPFLPLYVEELGIKDHESLNLWTGVAFSITFLFSAIAAPFWGKLSDRKGRKLMLLRSALGMAIVMVLIGFAQNIWQLLILRALLGVLGGFVPNANALIATQVPVKKSGWALGTLSTGAVSGALIGPLIGGILADLYGLRPVFFITAAVLFICFIVTLFFVSENFTPVSKKDALSTQQVFSSLKNKRLVICLFFTTMIIQVATGSVTPILTLYIRDLAGSISNLAFISGVIASVPGIAALISAPRFGKLGDRIGPDKVLIFTLGLSIFMLIPMALVSNYWELGALRFLLGAVNAAMLPAVQTLILYNITPAIAGRIFSYNQALRDVGNVTGPLMGAFVAANYGFRAVFYFTAAVVFFNLIYSWISFRTPQRK
What are the official names of this protein?
Multidrug resistance protein MdtG.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEC_BACCN
Sequence: MKKEKAVVVFSGGQDSTTCLFWAMQQFAEVEAVTFNYNQRHKLEIECAANIAKELGIKHTVLDMSLLNQLAPNALTRTDIDITHEEGELPSTFVEGRNLLFLSFAAVLAKQVGARHIVTGVCETDFSGYPDCRDAFVKSLNVTLNLSMDYPFVIHTPLMWIDKADTWKLSDELGAFDFVREKTLTCYNGIIGDGCGECPACQLRKAGLDTYLQEREGAKA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: Y1605_VIBC3
Sequence: MKIWVDADACPKVIRETLIRAAERTGVECTFVANHLIPLPKRDNIRALQVSSGFDIADNEIVRRTEAGDLVITADIPLADEVISKGGLALNPRGELYTKETIKARLNIRDFMDTMRASGIQTGGPAALSQTERREFANHLDRILAKRTG
What are the official names of this protein?
UPF0178 protein VC0395_A0405/VC395_0897.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: SOX9_CALJA
Sequence: MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPAGAGHVWMSKQQAPPPPPQQPPQAPPAPQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP
What is the function of this protein?
Transcription factor that plays a key role in chondrocytes differentiation and skeletal development.  Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6.  Also binds to some promoter regions.  Plays a central role in successive steps of chondrocyte differentiation.  Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes.  Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis.  Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression.  Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C.  Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation.  Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes.  Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors.  In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix.  Controls epithelial branching during kidney development.
What are the official names of this protein?
Transcription factor SOX-9.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFP_DESAH
Sequence: MYDASDLRKGLKFEIDGDPFVIVDFQFKKPGKGQALYKCKLRNMISGAQFERTFRSGDKFNEASLEEHDMEYLYSEGGNFCFMNSVSFEQEFLGKDQVGDAVNLLKDNTVCTVLFFNGKAIGLTLPNFVNLRIVQSDPWAKGDTATGSTKPATLETGYEIQVPPFVDEGQLVKIDTRTCEYVERVNE
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_FRATW
Sequence: MSTGKIIQVIGAVIDVEFARDNTPKVYDALNVVEAGLVLEVQQQIGDGVVRTIAMGSSDGLRRGMEVKNTNAPISVPVGHGTLGRIMNVLGEPIDEAGPIEYTEKRSIHQAPPAYDELALSTEILETGIKVVDLICPFAKGGKVGLFGGAGVGKTVTMMELINNIAKEHSGYSVFAGVGERTREGNDFYYEMKDSNVLDKVSLVYGQMNEPPGNRLRVALSGLTIAEGFRDEKRDVLMFIDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAAEMGALQERITSTKTGSITSVQAVYVPADDLTDPSPATTFSHLDATIVLSRQIAELGIYPAVDPLDSTSRQLDPLVVGQDHYETARAVQKVLQRYKELKDIIAILGMDELSDEDKKIVDRARKIQRFLSQPFHVAEVFTGNPGKFVSLKDTVASFKAIVNGEYDHLPEQAFYMVGSIQEAIEKAKTL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SSI_STRON
Sequence: SLYAPSALVLTIGQGDSASAGIQRAVTLSCMPTPSGTHPDARDACAQLRQADGKFDELTATKAGTYCTKEWNPVTVTATGVWEGQRVNYSHTFGNPCMAKAAKSTVFSF
What are the official names of this protein?
Protease inhibitor SIL-V2.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I16 (SSI) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL7_STRPG
Sequence: MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAAAAAGGAEEAAKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANVKEGVAAAEAEEIKAKLEEAGATITLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PLSX_CLOB1
Sequence: MIIAVDGMGGDFAPELVVEGCIQAVKEYEGIHIIITGKKELIKNELDKREYNGNKIEILNAEEVISTNEAPVKAIRRKKDSSMVKALELVKEGKAQAVISAGSTGALMAGATFVLGRIKGINRVCLAPLLPGAKAPFMIADAGANVDCKAEYLVQFAMMGKVYFESVLGVKSPTVGLVNIGAEEEKGNELTKAAYKLLKDTDFNFIGNIEPRDIPRGEVNIAVCDGFIGNTVLKTYEGVASNLFSMLKKEIMASTRGKIGGALLKPVFKDFKKKFDYTEYGGSPFLGAKGICIKAHGSSDAKAFKNAIRQAKICYDKKIIEEIENNLGNLIENNI
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.