PharMolix/UniProtQA huggingface dataset:
Protein: CASP8_MOUSE
Sequence: MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP
What is the function of this protein?
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:12065591, PubMed:18455983, PubMed:30361383, PubMed:30381458, PubMed:31511692, PubMed:31748744, PubMed:33397971).  Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PubMed:9654089, PubMed:9837723, PubMed:24813849, PubMed:24813850).  Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (By similarity).  Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A (PubMed:29440439).  The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (By similarity).  The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (By similarity).  Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (By similarity).  In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-325', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31511692).  Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-D (GSDMD): GSDMD cleavage promoting release of the N-terminal moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:30361383, PubMed:30381458).  Initiates pyroptosis following inactivation of MAP3K7/TAK1 (PubMed:30361383, PubMed:30381458).  Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (PubMed:32971525).  May participate in the Granzyme B (GZMB) cell death pathways (By similarity).  Cleaves PARP1 and PARP2 (PubMed:12065591).
What are the official names of this protein?
Caspase-8, CASP-8.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PLSX_RHIEC
Sequence: MIRISLDLMGGDFGPQVVIPGAAKALDRHPDISFVFYGLKEQCDPFLAKFPKLKEKSVFHDCELAVSMEEKPSQALRRGRYVSTMWRSIEAVKTGDADVAVSAGNTGALMAMAKFCLRTMANIERPAIAAIWPTLKGESIVLDVGATIGADAQQLMDFALMGGAMARALFEIERPTIGLLNVGVEEVKGQEEVKEAGRLLREANIDSLEYSGFVEGNDLGKGTVDVVVTEGFSGNIALKTAEGTAKQIAEYLRAAMSRTLLARIGYLFAKSAFDMLREKLDPSKVNGGVFLGLNGIVIKSHGGANAEGIAAAIEVGYDMAKNGLNQKIENDLKKYHAKRLPPIGPEAA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ARGB_ECO45
Sequence: MNPLIIKLGGVLLDSEEALERLFSALVNYRESHQRPLVIVHGGGCVVDELMKGLNLPVKKKNGLRVTPADQIDIITGALAGTANKTLLAWAKKHQIAAVGLFLGDGDSVKVTQLDEELGHVGLAQPGSPKLINSLLENGYLPVVSSIGVTDEGQLMNVNADQAATALAATLGADLILLSDVSGILDGKGQRIAEMTAAKAEQLIEQGIITDGMIVKVNAALDAARTLGRPVDIASWRHAEQLPALFNGMPMGTRILA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSH_ECO81
Sequence: MSKLDLNALNELPKVDRILALAETNAQLEKLDAEGRVAWALDNLPGEYVLSSSFGIQAAVSLHLVNQIRPDIPVILTDTGYLFPETYRFIDELTDKLKLNLKVYRATESAAWQEARYGKLWEQGVEGIEKYNDINKVEPMNRALKELNVQTWFAGLRREQSGSRANLPVLAIQRGVFKVLPIIDWDNRTIYQYLQKHGLKYHPLWDEGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHEG
What is the function of this protein?
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
What are the official names of this protein?
Phosphoadenosine 5'-phosphosulfate reductase, PAPS reductase, 3'-phosphoadenylylsulfate reductase, PAPS reductase, thioredoxin dependent, PAPS sulfotransferase, PAdoPS reductase.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysH subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_DEIDV
Sequence: MAKDGPRIIVKMESTAGTGFYYTTTKNRRNTQAKMELRKYDPVAKKHVVFKEKKV
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: Y001_BORBU
Sequence: MILMKYSAILLICSVNLFCFQNKLTTSRWEFPKEDLIKKKIKIGIIYHNYINSIFYNENYKYIAFIGILTSYNEWIEIQFSPINFFTIPTNKDFISNTYFNLAFTIYITKYSILTDTLAIKFFIGTQIDLTLRTTIFTGKTTHAFLYPILPIITFKFEIDFIPNNYSIYYKLSTSFKEFILLDLGISIFI
What are the official names of this protein?
Uncharacterized protein BB_0001.
Protein: DNLJ_LACAC
Sequence: MADITLDEAKKEASLLRNQLDKWADAYYSKDAPEVEDNVYDQKYSRLLELEKQFPEIVTPDSITQRVGGEIDSDFTKVEHAIPMLSMGDVFSKDELKDFDQRMQKLVGHPVEYNVELKIDGLSLSLEYENGKLMRASTRGNGYVGEDVTANARYIADIPQTLPEPLTIEVRGECYMGKEAFAKLNEERENEGLSVFANPRNAAAGSLRQLDPKVTKKRQLSTFIYTWVNPPEDITSQHEAIKRMQELGFHTNETGQKLASLEEIFAFIDEYTARRDSLAYGIDGIVLKIDDLNIERSLGNTVKVPRWEIAYKFPPEEQETIVRDIVWTVGRTGVVTPTAVMDPVQLAGTTVARASLHNPDYLNEKDVRLGDTVKLHKAGDIIPEISEVVLSKRPVDSVPYVIPENCPSCGHKLVHLQDEVALRCINPSCPAQVEEGITHFASRPAMNIAGLGPKIVKQLIANDLVHNVADLYHLSAEDLAQLDHFKEKSINNLLTAIDNSKKNSVELLITGLGIDHVGAKAARLIAQKFKNLAKIMSLGVQDLASIDTIGMTIAESMTTYFAQPEAQEMIADLEKSGLNMEYLGEDEPEDIPDNPFKDKTVVLTGKLEHYTRSEFTKRLQALGAKVTGSVSKKTNYVIYGQDAGSKYNKAEQLGIPLLTEEEAIAQIK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ECNB_CITFR
Sequence: MVKKTIAAIFSVLVLSSVLTACNTTRGVGQDISEGGSAISGAGTKAQQ
What is the function of this protein?
Plays a role in the bacteriolysis.  Is activated under conditions of high osmolarity by the factor sigma S.  Entericidin A functions as an antidote.
What are the official names of this protein?
Entericidin B.
What is the protein family that this protein belongs to?
Belongs to the EcnA/EcnB lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CXB3_MOUSE
Sequence: MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTRQPGCTNVCYDNFFPISNIRLWALQLIFVTCPSMLVILHVAYREERERKHRQKHGEQCAKLYSHPGKKHGGLWWTYLFSLIFKLIIELVFLYVLHTLWHGFTMPRLVQCASIVPCPNTVDCYIARPTEKKVFTYFMVGASAVCIILTICEICYLIFHRIMRGISKGKSTKSISSPKSSSRASTCRCHHKLLESGDPEADPASEKLQASAPSLTPI
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction beta-3 protein, Connexin-31, Cx31.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Beta-type (group I) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: SECY_ANTSP
Sequence: MKQPTTNKLRFTITLVILFLARVGIFIPISGIDHQTFNNTIQQNGIINFLNIFAGGGFSTIGIFALGIVPYIYASIIIQLLIKLIPYLENLQKEEGEIGRQKINQLTRYLTLLWALIQSLSIAIWINHMYLIHLFELCASLTTSSMIAMWFSEIISEYGVGNGPSLLIFQNIISSIPKNLQNYTFNIGTTNTVLNGSLILSFGIIILIINILIQEGERKIAILSAKQLGKINELNHKVIFLLKLNQGGVMPFVFASAVVHTFLFISNNTNSKITQFINLFLPNQFLYLPLYLIFIITFSYVYTSLILNPEDIAKNLKKMGASIPNIRPGSETIKYLNTRINRLTLIGACFLFTITLFPTITYYIFKINTLKGLGATSLLILVGVAIDTAKQIQTYLYHTYDNMME
What is the function of this protein?
The central subunit of the protein translocation channel SecYE.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DEOB_SALTY
Sequence: MKRAFIMVLDSFGIGATEDADRFGDVGSDTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLVKAHEGSTGKIAAGMDGNADVIGAYAWAHELSSGKDTPSGHWEIAGVPVLFDWGYFSDHENSFPQELLDKLVKRANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTEGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKQGHVVSVGKIADIYANCGITKKVKATGLDALFDATLKEMKEAGDKTIVFTNFVDFDSSWGHRRDIAGYAAGLELFDRRLPELMELVGEDDILILTADHGCDPSWTGTDHTREHIPVLIYGPKVKPGSLGHRETFADIGQTLATYFGTSPMDYGKNML
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_VIBHA
Sequence: MGKIIGIDLGTTNSCVAVLDGDKPRVIENAEGERTTASVIAYTDGETLVGQPGGNVNAVTNPTRYTLFAIKRLIGRRFEDEEVQRDIEIMPYKIVKADNGDAWVEAKGQKMAAPQVSAEVLKKMKKTAEDFLGEEVTGAVITVPAYFNDAQAQATKDAGRIAGLEVKRIINEPTAAALAYGLDKSGGDRTIAVYDLGGGTFDISIIEIDEVEGEKTFEVLATNGDTHLGGEDFDNRLINYLVDEFNKEQGINLKNDPLAMQRVKEAAEKAKIELSSTSQTDVNLPYVTADATGPKHMNIKVTRAKLESLVEDLVQRSLEPLKVALADADLSVNDITDVILVGGQTRMPMVQAKVAEFFGKEARRDVNPDEAVAMGAAVQGGVLAGEVKDVLLLDVTPLSLGIETMGAVMTKLVEKNTTIPTKANQVFSTAEDNQSAVTIHVLQGERKQASFNKSLGQFNLEGIQAAPRGMPQIEVTFDLDADGILHVSAKDKQTGKEQKITIQASGGLSDDDIEKMVQEAEANKEADKKFEELATARNQADQMIHGTRKQVEEAGEALPAEEKEKIEAAISELETARKGDDKEAIDAKVQALMTAAQKLMEIAQQQAQAQQAQGGYAGAQQSQEDDVVDAEFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TTCA_ACTSZ
Sequence: MTEQTEKDKKQIYNLNKLQKRLRRNVGNAIADFNMIEEGDKVMVCLSGGKDSYTLLDILLNLKFSAPIHFDIVAVNLDQKQPGFPEHVLPQYLESIGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDMLATLFLNMFYGGKLKSMPPKLISDDGKQIVIRPLAYCKEKDIEKYAVAKQFPIIPCNLCGSQPNLQRQVVKEMLNTWDRQYPGRLETMFSAMQNVVPSHLCDPNLFDFKNIRRGQILEGVSGDIAFDKEELPPMPQFADEGESADFSGENLIQFKEVN
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAJQ_SALDC
Sequence: MPSFDIVSEVDLQEARNGVDNAVREVESRFDFRGVEATIELNDANKTIKVLSESDFQVNQLLDILRAKLLKRGIEGASLDVPDEFVHSGKTWYVEAKLKQGIESAVQKKIVKLIKDSKLKVQAQIQGEEIRVTGKSRDDLQSVMALVRGGDLGQPFQFKNFRD
What are the official names of this protein?
UPF0234 protein YajQ.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: PMG2_YEAST
Sequence: MTASTPSNVMTLFLLRHGQSELNHENIFCGWIDAKLTEKGKEQARHSAELIEQYCKANNLRLPQIGYTSRLIRTQQTIETMCEEFKLKPQLQVVYDFNKIKLGDEFGSDDKDNMKIPILQTWRLNERHYGSWQGQRKPNVLKEYGKDKYMFIRRDYEGKPPPVDLDREMIQQENEKGSSTGYEFKEPNRQIKYELECSNHDIVLPDSESLREVVYRLNPFLQNVILKLANQYDESSCLIVGHGSSVRSLLKILEGISDDDIKNVDIPNGIPLVVELDKNNGLKFIRKFYLDPESAKINAEKVRNEGFIKNP
What is the function of this protein?
Could be non-functional.
What are the official names of this protein?
Phosphoglycerate mutase 2, PGAM 2, BPG-dependent PGAM 2, MPGM 2, Phosphoglyceromutase 2.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: TBB6_MOUSE
Sequence: MREIVHIQAGQCGNQIGTKFWEVISDEHGIDQAGGYVGDSALQLERISVYYNESSSKKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDSVLDVVRKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQNKNSSYFVEWIPNNVKVAVCDIPPRGLKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVNDGEEAFEDEDEEEINE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-6 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL15_HELPH
Sequence: MIMGLENLKPAKGSVKKIKRVGRGQGSGMGKTATRGGKGQTARTGYKAKRGFEGGQQPLQRRLPKIGFRTKDSHIYSINVEKNEAIKNLEEITFSSLRALHHFPLYIEGVKLIGKDAKNLASKIKDERIKTSGQK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: YCF29_CYAPA
Sequence: MINILILDTDIGIRNSLKLYLTEIGFHVEESTCVDQAWDILKRKKIDLIICDIIMPGMGGFNFLHQLRLNTDYCTLPVILLTTRGLTQDRIIGYKTGCDSYISKPFNIEELVVIIEGVLNRHTLIRLKLEKKQKNSFLLIKSNNLKINFTPREQSVLNLVVEGLLNKQIAANLNISIRIVEKYVSRLFIKTKTRNRAELVKYALENNLIT
What are the official names of this protein?
Probable transcriptional regulator ycf29.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: RL23_FRATM
Sequence: MSSQEKLLKTVIRPHVSDKTYGLSDANSTIVFEVARFANKQDVKNAVEKLFEVKVESVNILNVKGKARRFGRVEGRTKAWKKAYVKLAEGHDINFVGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: DNAJ_STRA3
Sequence: MNNTEFYDRLGVSKDASQDEIKKAYRRMSKKYHPDINKETGAEEKYKEVQEAYETLSDTQKRAAYDQYGAAGANGGFGGFDGGGFGGFDGGGFGGFEDIFSSFFGGGGMRNPNAPRQGDDLQYRVNLSFEEAIFGAEKEVSYNRESSCHTCSGSGAKPGTSPVTCQKCHGSGVINVDTQTPLGTMRRQVTCDVCQGSGQEIKEKCPTCHGTGHEKKTHKVSVKIPAGVETGQQIRLTGQGEAGFNGGPYGDLFVIINVLPSQQFERNGSTIYYTLKISFVQAALGDTIDIPTVHGAVEMSIPAGTQTGKTFRLRGKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQKEALHAFAEASGDKMVHPKKKGFFDKVKDALDVD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: L3BPA_DANRE
Sequence: MIMYIIWALLFIPVSAQQWTLFDEQAKPKREGRVRLVGGLPSSGRVEVYHDGQWGTVCDDGWDLAEAQVVCRQLGFPGAVSVASGGQYGEGSGPIWLDDMNCKGSESILSECCFKGWGVNDCTHQEDAGVVCDTGTNATNIRQISVDNSLGLSDDLGLLFDSEDGCDFIIAVQDLGEEAELTLCVHRVILMMYPELNITNDTRNLTVDVSQTCQSHVSALIRYLYTRQIDVSATSAQCLYQLAFIFGVQRLMEDVGRVFTALIPEDNTFQTPVSMYEYGLRTGDLVLQENVLQYLSWNCEFLISSPVWSTVSFEMMDALLQRSDLIVKDEAVLLEALERWIQDKGDQISSDKQASLLSHIRFLLIPVDKLYDIQFSSSALYQNNEKLYLTGLLRGFEFNALPFSKIRNQIDNASSEYLPRIYTGDEWSVFINDTTVSSPYYNYNYYGQSNRIQTFFTSAHPSALYKDQKVQWQAQVFLTLQECSNYGVSCNTLPVARFYGYSNQYSYSNIISYNNRLILTCKNQNNVFHVQEFKNDVAVIPTNSSMGLPNPCPDDYSFRFVVRPQYI
What is the function of this protein?
Promotes integrin-mediated cell adhesion.
What are the official names of this protein?
Galectin-3-binding protein A, Lectin galactoside-binding soluble 3-binding protein A.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space, extracellular matrix.
Protein: 3HAO_COCIM
Sequence: MLAPALNLPKWLEENSHLLQPPINNYCVYHPSAPATQGYTVMVVGGPNVRTDYHINPTPEFFYQHRGSMLLRTVDQSTSPPTFQDIPIHEGSLFLLPANTPHCPVRFADTVGVVLEVPRPENATDCMRWYCKGCGEIVWEKKFHCTDLGTQVKEVVEEFAADDEKRKCKACGSVRSVRYEDGEVVQPPRAPE
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD, Biosynthesis of nicotinic acid protein 1.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_MORCA
Sequence: MTITTEDILDCANLSRLALDEKTAQNYAGNLDKILAMMDILDGVNTDNIKPLANIHEACNELRADIANSDIGRDGFQAVAPMVQDGLYLVPQVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: ZAT10_ARATH
Sequence: MALEALTSPRLASPIPPLFEDSSVFHGVEHWTKGKRSKRSRSDFHHQNLTEEEYLAFCLMLLARDNRQPPPPPAVEKLSYKCSVCDKTFSSYQALGGHKASHRKNLSQTLSGGGDDHSTSSATTTSAVTTGSGKSHVCTICNKSFPSGQALGGHKRCHYEGNNNINTSSVSNSEGAGSTSHVSSSHRGFDLNIPPIPEFSMVNGDDEVMSPMPAKKPRFDFPVKLQL
What is the function of this protein?
Transcriptional repressor involved in abiotic stress responses.  Can repress the stress responsive genes DREB1A and LTI78.  Probably involved in jasmonate (JA) early signaling response.  May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade.
What are the official names of this protein?
Zinc finger protein ZAT10, Salt-tolerance zinc finger.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSLO_LACLS
Sequence: MDKIIKSISKNGHFRAFALDSTLTVREAQERHQTWPTSTVALGRTLIAAQVLGANEKGDTKITVKVLGDGAMGPIIAVADSKGHVKGYVKNRELDYKKASTGEVLVAPFVGNGFLVVVKDMGLKQPYSGQVDLITGEIGEDLAWYFLSSEQTPSSVGVNVLLNEDSDTVKIAGGFMLQALPDATDEEITEIEHNIKSMPSIATMLTSDEPLKTMLDNIYGDMEYKNLGEFPLAFKCDCSKERFLEGIKSLGREPIEEMIAEDHGAEIICQFCENKYEYSEEELKALIN
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_MYCSM
Sequence: MSKGRLFTSESVTEGHPDKICDAISDSVLDALLEQDPKSRVAVETLVTTGQVHVAGEVTTTAYADIPKIVRDRILDIGYDSSTKGFDGASCGVNVAIGAQSPDIAQGVDTAHETRVEGKADPLDLQGAGDQGLMFGYAIGDTPELMPLPIALAHRLARRLTEVRKNGVLDYLRPDGKTQVTIQYDGTTPVRLDTVVLSTQHADGIDLEGTLTPDIREKVVNTVLADLGHETLDTSDYRLLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGSETVDPAKIEKAIGEVFDLRPAAIVRDLDLLRPIYAPTAAYGHFGRTDIELPWEQTNKVDDLKSAI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_BACAC
Sequence: MSFNHQEIEKKWQGYWEENKTFRTPDETEKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNSPAEFTEHNINTFRNQIKSLGFSYDWDREVNTTDPNYYKWTQWIFLKLFEKGLAYVDEVPVNWCPALGTVLANEEIIDGKSERGGHPVERRPMRQWMLKITAYGDRLLEDLDELDWPESLKDMQRNWIGRSEGAEVHFNIDGTDEKFTVFTTRPDTLFGASYCVLAPEHALVADITTADQKEAVEAYINSVKMKSDLERTELAKEKTGVFTGAYAVNPVNGEKLPIWIADYVLATYGTGAVMAVPAHDERDYEFASTFNLPMKEVVKGGDITKEAYTGDGAHVNSAFLDGLNKEEAIAKMIEWLEVTSAGNQKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMTAVKEEELPLVLPKTENIRPSGTGESPLANIDEWVNVVDPETGKKGRRETNTMPQWAGSCWYYLRYIDPNNSEALVDPEKVKQWLPVDIYIGGAEHAVLHLLYARFWHKVLYDIGVVPTKEPFQQLFNQGMILGENNEKMSKSKGNVVNPDDIVASHGADTLRLYEMFMGPLDASIAWSENGLDGARRFLDRVWRLFVQDNGELSEKITDAPNKDLEKAYHQTVKKVTEDYAELRFNTAISQMMVFINDAYKAETLPKEYVEGFVKMIAPVAPHIGEELWSKLGYNETITYASWPTFDESKLVEDEVEIVVQVMGKVRAKLTMSKDASKDEMEKLALEAIQDQIEGKTVRKVIVVPGKLVNVVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OCD_BRUSU
Sequence: MTQPNLNIVPFVSVDHMMKLVLRVGVETFLKELAGYVEEDFRRWQNFDKTPRVASHSKEGVIELMPTSDGTLYGFKYVNGHPKNTRDGLQTVTAFGVLANVGSGYPMLLTEMTILTALRTAATSAVAAKHLAPKNARTMAIIGNGAQSEFQALAFKAILGVDKLRLYDLDPQATAKCIRNLQGAGFDIVACKSVEEAVEGADIITTVTADKANATILTDNMVGAGVHINAVGGDCPGKTELHGDILRRSDIFVEYPPQTRIEGEIQQLPEDYPVNELWEVITGRIAGRKDARQITLFDSVGFATEDFSALRYVRDKLKDTGLYEQLDLLADPDEPRDLYGMLLRHEKLLQSESTKPAA
What is the function of this protein?
Catalyzes the conversion of L-ornithine into L-proline with release of ammonia.
What are the official names of this protein?
Ornithine cyclodeaminase, OCD.
What is the protein family that this protein belongs to?
Belongs to the ornithine cyclodeaminase/mu-crystallin family.