PharMolix/UniProtQA huggingface dataset:
Protein: COX2_LACK1
Sequence: MLTFLSNLNNMIIMNDVPTPYGVYFQDSATPNQEGILELHDNIMFYLLVILGLVSWLLFTITRTYSKNPIAYKYIKHGQTIEIIWTIFPAVVLLIIAFPSFILLYLCDEVISPAMTIKAIGLQWYWKYEYSDFINESGETVEFESYVIPEDLLEDGQLRLLDTDTSVVVPVDTHIRFVVTAADVIHDFAIPSLGIKVDATPGRLNQVSALIQREGVFYGQCSELCGTAHSAMPIKIEAVSLPSFLEWLNEQ
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MURQ_HISS2
Sequence: MNKQNLINQFAQLITEQPNPLSVNLDQMSALEIVQLMNKEDQQVPLVIAKALPEIAVVVEKIVAAFRQGGRLVYLGAGTSGRLGVLDASECPPTFGVNHEMVKGIIAGGEQAIRYPVEGAEDNQQAAIVDLQAIQLCSKDILVGIAASGRTPYVISGLKYAKEIGSFTVAIASNPQSAMAKIADIGIETIVGPEILTGSSRLKSGTAQKLVLNMLTTASMVLLGKCYQNLMVDVQASNEKLVDRATRIIMQATGCERAKAEQTLTQADNNAKLAILMILMDLDKQSAVDLLAKNQDKLRQTLD
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: LEPA_ECOUT
Sequence: MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVTLDYKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSWFDNYLGVVSLIRIKNGTLRKGDKVKVMSTGQTYNADRLGIFTPKQVDRTELKCGEVGWLVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVETTSREVIYVDSPSKLPAVNNIYELREPIAECHMLLPQAYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINGERVDALALITHRGNSQNRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1142_PECCP
Sequence: MAYLDPTLLILLVLAGLGIISHNMTVTLAILVLLAIRITPLNSYFPWVEKYGLSIGIVILTIGVMAPIASGKITASEVMHSFLHWKSLLAILIGVAVSWLGGRGVSLMSNQPSVVAGLLVGTVMGVALFRGVPVGPLIAAGLLSLLIGKT
What are the official names of this protein?
UPF0756 membrane protein PC1_1142.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YIAA_ECOLI
Sequence: MDNKISTYSPAFSIVSWIALVGGIVTYLLGLWNAEMQLNEKGYYFAVLVLGLFSAASYQKTVRDKYEGIPTTSIYYMTCLTVFIISVALLMVGLWNATLLLSEKGFYGLAFFLSLFGAVAVQKNIRDAGINPPKETQVTQEEYSE
What are the official names of this protein?
Inner membrane protein YiaA.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL4_MESM1
Sequence: MAEELKKTTKEKTPVKKSSKVSASKAPTKKVTKTTEVKKADKLEKVSKPKSESTKVSKVSVKSVKTESIKSEPVKTKKSKIKVLSSKTNEAKNILFKNTVSLPKGIFGLSEEKINTQAIFDSILFERASQRQGTHSTKTRSEVSGGGKKPWKQKGTGRARAGSTRSPIWVGGGITFGPKPQKKYDFKINKKVRNLAFLSSLTLLANKNAILVEDLKLEKISSQELIKKLEDLKINNLKKILIVSDDEKIFKSGRNVQNLHVVKLNSLTVELLNETHALLLSKKDLTTLESRVK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: MURQ_THEFY
Sequence: MHTAPVEIVRAPTEARNSSTKDIDLLPTADILRLINAEDATVPRAVAEVLPELAKAVDLGVSVLRHGGRIHYFGAGTSGRLATMDAAELPPTFGIARDRVVAHHAGGPSALIHACEGIEDDFSSGRADAATVTSADLAIGLTASGRTPYVAGALDRAREAGARTVLVTADPHSALAADVDVHIGVATGAEVIAGSTRMKAGTAQKLILNAFSTAVMVRLGYTYSNLMVGVVATNAKLRGRMVTILTEATGLSEEDCAEALHRADGDTRIALVCLLTGVDVPTAAHALHAAHGSVRAALRELART
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: TATA_PSYIN
Sequence: MGGIGIWQLAIITVIVILLFGTKKLRGIGGDLGGAIKGFKKAIKEDNDKDSTQVDDKDSTQVDDNAKQPSNKKVEENIKEQSKEKDRA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ATAD1_MOUSE
Sequence: MVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNENVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAIEKMKKSKDAAFQNVLTHVCLD
What is the function of this protein?
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity).  Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity).  Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (PubMed:21496646).  Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646).
What are the official names of this protein?
Outer mitochondrial transmembrane helix translocase, ATPase family AAA domain-containing protein 1, Thorase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. MSP1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Postsynaptic cell membrane; Single-pass membrane protein.
Protein: HRCA_HELPY
Sequence: MLRRIKVGSNLNKKESLLDAFVKTYLQILEPISSKRLKELADLKISCATIRNYFQILSKEGMLYQAHSSGARLPTFKAFENYWQKSLRFETLKVNEKRLKSASENFGLFTLLKKPSLERLERVIECEKRFLILDFLAFSCALGYSVKMEKFLLELVGRSVKEVRSIAASFNALSLARQLERLEYSNTQITRFNLMGLKTLLNSPLFFDILGGKVLERLSKGLHFIEPDCMLVTRPVEFQNKRMQLLCVGKLECDYEGFFQTISEEE
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: TRAP_STAES
Sequence: MYLYTSYGTYQFLNQIKLNHQERSLFQFSTNDSSIILEESEGKSILKHPSAYQVIDSTGEFNEHHFYSAIFVPTSEDHRQQLEKKLLLVDVPLRNFGGFKSYRLLKPTEGSTYKIYFGFANRTAYEDFKASDIFNENFSKDALSQYFGASGQHSSYFERYLYPIEDH
What are the official names of this protein?
Signal transduction protein TRAP, Target of RNAIII-activating protein.
What is the protein family that this protein belongs to?
Belongs to the TRAP family.
What are the subcellular locations of this protein?
Membrane. Note=Membrane-associated.
Protein: NUOB_BURL3
Sequence: MSIEGVLKEGFVTTTADKLINWTRTGSLWPMTFGLACCAVEMMHAGAARYDLDRFGVVFRPSPRQSDVMIVAGTLCNKMAPALRRVYDQMAEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALVYGVIQLQAKIRRTNTIARQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PDE5_DICDI
Sequence: MMFSKRKSIRFNPEGDYTELPRGGYVVPSKLGGIQFGVPPETIKDSMALKIDVPTIYVFPEELWDRKTGINAAEAEFPAYFNYFILKRKVSFVCTKEQEQRIRIVFQETLLGPPEFNTGIIINSSSSTTDTSKTSPIKKQTSSSSPPLSPQQQQPPPPLVKQPSQQQLEELATMDTCHYHHHHHHQEVNDNDNNNNTTTNNNNIEILEQQQQQQQQQQQQQDEDSTDVDEEFQKEFSSTFPRSEIPNLEKECKYLRTFNSVDELFDFILFDDNGIAKLSDDVEIHFQEDQSLFKVLQFEETGKGNKVQTLVATIPSKILFPDMINSISTINDNKIFDPPTFGITIIGSSHGFDPKKSTTGFVLWINKRGIMVDPPLNSSSFLQSQGVPTRMVDHIILTHCHADHDSGTFQKLLEEYQITVVTTPTILGSFLRKYGALSNLSTDLLRRLFIFRPVMIGEPMIISGAEFRFFYTIHTIPTISFEVFYGGKSIFYSGDTCYDPNRIKDMNKRGIMKTSRMKFFLRPWNHTVVLHEAGVPPIHTPVSVLRALPDEVKNRLYLVHISEHTLPAGSGLKIAKEGVAHTLSLDVMKSSHSEAVDILKLVESVDIFRSIPLTQACEILQTATKRKYSQGSVIIARDTEPDAFYVVASGVVCVNIGELKKNLIVGDYFGEMSLVMGGLRSANVQAVTDVEVLSFNKEDFLSITRNSTESIQFITRLWEMRNEKSWETMSLNSVFSRCTNSQKTAIQSILVRELIKKDETLWCKGEEALFGCLVAEGSFVFKEDDSLESFSQGSFLGDINAMTTQPPSIHKTTVVAKEESVIYKVLSQDLIKFFSNNPGIQLAFLDTIFVDALRDQVQQLVNSKLTY
What is the function of this protein?
Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP (PubMed:12429832, PubMed:12429831) (Probable).  Involved in the degradation of intracellular cGMP, contributes to the control of cGMP signals (PubMed:12198158, PubMed:12429832).
What are the official names of this protein?
cGMP-dependent 3',5'-cGMP phosphodiesterase A, Cyclic GMP-binding protein A, Phosphodiesterase 5, DdPDE5, Phosphodiesterase D.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family.
Protein: ISY1_ASPFU
Sequence: MLFRFRAQQAADLGIIDIGRTRRPKAITSVDSIPSCEKWRGQVLKEISRKVSRIQEPSLSDYQIRDLNDEINKLMREKWAWEMQIRNLGGPNYMRGSGRVYDDEGREIPGGGKGYRYFGRARELPGVKEMFEAAARRGRRPPEEEEEEEGKGRGGDIATKKVDANYFGYGLDEEDGSLLAYERQKEKEAVEYLRGQKDSDAEDGWEPLPGDAGDGVEWRLPTLEEVQEELVDRRRRRLLDKIS
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor isy1.
What is the protein family that this protein belongs to?
Belongs to the ISY1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SENP_CAEEL
Sequence: MSRRSDLSDKDSQSRKRHWLTDQAVTNEEKEQSPTKRTRKTKSQGLGGLFNTFFGMFVSSNSGEKEKTEVSGEVQVQEDDEIIVEGTTRRVAENKKYMIFLNEDAPVRANAGSEENEVIIEKHVQKNVEIRNDEEKQEVQGDLVLTLSSSPKSPKNLEKSFEVQQDDEEPDVLFEKVVKTPNKQLQEARRFQNELIFLNDNPDTPDDVSVISDSRSKEFISPTPDDSVSRPITPSLSSLSNYTSNNVRDYWRRNSAKKPEVLRRVPVRHQFKHSTSVRKMNTIIDLKKIKNHLSSRDRLLQGVVASGQYEAKAISGIVEKKPKKMQRTSSTDILARAKNKIAELGGSRSNTPSLLSREPSIIIDSEESTSSSYRQHARSNSSESDSYRKLNDILSQINSLGIGSAYRGPQRYQNSYQLSKQKEDKLLEEARIREGHRSQTRGDRLEDVRKRLELQGIAIRPKVEKKKVDDFMALPDAADALVERAWSGGNPNEQFVDAFSIQICKKDLATLSGLHWLNDEIINFYLQLICDRSNGDSKYPKIYAFNTFFYSNIVSKGYASVKRWTRKVDIFAFDIVLVPVHLGMHWCMAVIDMGEKKIEFYDSLYDGNTAVLPALRGYLEAESLDKKKTAMNFSGWTIQQMTDIPRQQNGSDCGVFSCQFGEWASRRTTPRFTQKNMPYYRKRMVYEIVSKKLLATI
What is the function of this protein?
Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form.
What are the official names of this protein?
Sentrin-specific protease, SUMO protease, SuPr, Ubiquitin-like protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase C48 family.
What are the subcellular locations of this protein?
Nucleus envelope.
Protein: RS3_CLOBJ
Sequence: MGQKVHPHGLRVGVIKEWDAKWYADKKNFADNLVEDHKIRNFVKKNSYAAGVSRIEIERAAKRIKLNIYTAKPGMIIGKGGQGIESLKNKLQKIVSNKNILINIVEVKRPEADAQLIAENIAQQLEKRIAFRRAMKQSIQRAMKSGVKGIKTACSGRLAGAEIARTEHYNEGTIPLQTLRADIDYGFAEADTTYGKIGVKVWVYKGEVLPARKNINEKEEANA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DEF2_MESMA
Sequence: METIVLLFLLALVFCTLEMGMVEAEHGCPDNEDECHEHCKSIGKSGGYCVGPHKQTCRCNP
What is the function of this protein?
Antibacterial peptide active against Gram-positive bacteria, but not on Gram-negative bacteria (By similarity).  Has also weak blocking activity on Kv1. 1/KCNA1, Kv1. 2/KCNA2, Kv1. 3/KCNA3, KCa3. 1/KCNN4/IK, KCa2. 3/KCNN3/SK3 and Kv11. 1/KCNH2/ERG1 channels (tested at 1 uM) (By similarity).  It inhibits potassium channel current by interacting with the pore region (By similarity).
What are the official names of this protein?
Defensin BmKDfsin2.
What is the protein family that this protein belongs to?
Belongs to the invertebrate defensin family. Type 2 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBA_EUGGR
Sequence: MISPVLKKYARPSLWYRFCAWVASKKNRLYVGWFGVLMIPTLLTAATVFIIAFIAAPPVDIDGIREPVSGSLFYGNNIITGAVVPTSNAIGLHFYPIWEATSLDEWLYNGGPYQLIVCHFFIGICSYMGREWELSFRLGMRPWIAVAYSAPVAAASAVFIVYPLGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLLRETTENESINVGYKFGQEEETYNIIAAHAYFGRLIFQYASFNNSRSLHFFLAVWPVVGIWFTALGVSTMAFNLNGFNFNQSVIDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLA
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, 32 kDa thylakoid membrane protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: FRL_DROME
Sequence: MGAVKSRTITSADVDADEQLQHPHSHAHHHSMRNGHQHNGSISSGTLQKQDLRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRLSRTLEEMDC
What is the function of this protein?
Together with Cdc42, involved in establishment of planar cell polarity in the developing compound eye by contributing to ommatidial rotation.  Together with DAAM and Cdc42, has a role in neuronal development of mushroom bodies.
What are the official names of this protein?
Formin-like protein, Formin related in leukocytes.
What is the protein family that this protein belongs to?
Belongs to the formin homology family.
Protein: GCST_FLATR
Sequence: MRGGLWQVGQSITRRLGQSDKKTIVRRWYASEADLKKTVLYDFHVANGGKMVPFAGWSMPIQYKDSIMESTINCRENGSLFDVSHMCGLSLKGKDCVAFLEKLVVADVAGLAPGTGSLTVFTNEKGGAIDDSVITKVTDDHIYLVVNAGCRDKDLAHIEQHMKAFKAKGGDVSWHIHDERSLLALQGPLAGSTLQHLTKDDLSKMYFGDFRIIDISGSKCFLTRTGYTGEDGFEISVPSENAVDLAKAILEKSEGKVRLTGLGARDSLRLEAGLCLYGNDMEQHITPVEAGLTWAIGKRRRAEGGFLGAEVILKQIADGPAIRRVGLFSTGPPARSHSEIQNEQGENIGEVTSGGFSPCLKKNIGMGYVKSGLHKPGTKLKIVIRGKTYEGSVTKMPFVPTKYYKPA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, mitochondrial, Glycine cleavage system T protein, GCVT.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SUCC_PHOLL
Sequence: MNLHEYQAKQLFARYGLPAPAGYACTTPREAEEAASKIGSGPWVVKCQVHAGGRGKAGGVKVVNSKEEIRAFAEQWLGKRLVTYQTDAQGQPVRQILVEAATDIAKELYLGAVVDRGTRRVVFMASTEGGVEIEKVAEETPELIHKAIIDPLIGPMSYQGRELAFKLGLTGKQVSQFTKIFLGLANLFLERDLALVEINPLVITTQGDLICLDGKLGADGNALFRQAELREMHDPSQEDPREAQAAQWELNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGAPANFLDVGGGATKERVTEAFKIILSDENVKAVLVNIFGGIVRCDLIADGIIGAVEEVGVHVPVVVRLEGNNAELGAKKLADSGLNIIAATSLTDAAKQAVAAVEAK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: EFTU_RICM5
Sequence: MAKAKFERTKPHVNIGTIGHVDHGKTSLTAAITIVLAKTGGAQATAYDQIDAAPEEKERGITISTAHVEYETKNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLAKQVGVPAMVVFLNKVDMVDDPDLLELVEMEVRELLSKYGFPGDEIPIIKGSALQALEGKPEGEEAINELMDAVDSYIPQPVRATDKPFLMPIEDVFSISGRGTVVTGRVESGIIKVGDEIEIVGLKDTQKTTCTGVEMFRKLLDEGQAGDNVGILLRGTKREEVERGQVLAKPGSIKPHDKFEAEVYVLSKEEGGRHTPFTNDYRPQFYFRTTDVTGTIKLPADKQMVMPGDNATFTVELIKPIAMQEGLKFSIREGGRTVGAGVVTKINN
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AL1A1_RABIT
Sequence: MADLPTPLTNLKIQYTKIFINNEWHDSVSGKKFPVLNPATEEQICLIEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESLNAGKLFPNAYLMDLGGCIKTLRYCAGWADKIQGRTMPMDGDFFCYTRHEPVGVCGQIIPWNFPLVMLIWKIGPALSCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDNAVEFAHQGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLAPEVNQGPQIDKEQYNKILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTTYGLSAGIFTKDLDKAVTVSSALQAGTVWVNCYSVVSAQVPFGGFKMSGNGRELGEYGLQQYTEVKTVTVKISQKNS
What is the function of this protein?
Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160).  Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid.  This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity).  Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic.  By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160).  Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity).  Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
What are the official names of this protein?
Aldehyde dehydrogenase 1A1, 3-deoxyglucosone dehydrogenase, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, RALDH 1, RalDH1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell projection, axon.