PharMolix/UniProtQA huggingface dataset:
Protein: RRAAH_MYCBP
Sequence: MAISFRPTADLVDDIGPDVRSCDLQFRQFGGRSQFAGPISTVRCFQDNALLKSVLSQPSAGGVLVIDGAGSLHTALVGDVIAELARSTGWTGLIVHGAVRDAAALRGIDIGIKALGTNPRKSTKTGAGERDVEITLGGVTFVPGDIAYSDDDGIIVV
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: MTLD_PSYIN
Sequence: MKAIHFGAGNIGRGFIGKVLSDAGIKVTFADVNKTVVNALIARNEYDVNVVGADCVVEKVTNVTAVNSAGSEIVKLIAESDLVTTAVGPTVLNIIAKTIADAIELRLNSGNKFPLNIIACENMVRGTSQLKAQVFKYLPESLHVQSDQTIGFVDCAVDRIVPPAEAGETDPLAVTVETFSEWIVDQTQFKGEIPTIKGMECTDNLMAFVERKLFTLNTGHLITAYLGVLAGYETIKESIEDEAIRSDVTAAMQESGEVLIRRYGFDPQAHAAYIQKILGRFANPYLRDEVDRVGRQPIRKLSANDRLIKPLNGTLEYGLPNGHLIKGIAAAFLYKNDQDPQAVELQAMFAEKGLAATLAHYSGLAVDSETVKLVEQAYQSLK
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: PXPA2_BORBR
Sequence: MPSIDINCDMGESFGPWVMGQDTELMPHITAANIACGFHAGDPDVMLATVRAAIAADVAIGAHPGLPDLQGFGRRVMAVTPDEVYALTVYQVGALQAIARSQGGRLHHVKTHGALYTLTARDPALADAVARAVADVDPALPIYVANAAIAQATRERGLRAVYEVYADRSYQDDGTLTPRSQPHAMIEDVDQAIAQVKRMVKEGVVRALSGKDVPITADTLCIHGDQPGAALFARRIRAALEAEGIEIRTV
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A 2, 5-OPase subunit A 2, 5-oxoprolinase (ATP-hydrolyzing) subunit A 2.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: NRFA_HAEDU
Sequence: MKYLTKSRVIATIAMLGCLSVSAWAETPTNQPESLTDKALKHEKLGVVVESANHKFAEKYRLQYDSWKATAESTDRSSALEADPRLVVLWAGYAFAKEYNKPRGHYYAVTDVREILRTGAPKDENDGPQPMACWTCKGPDVPRLIEEKGERGYFDPKWAKYGAEIVNSIGCADCHDTTSKAFEEGKPALRVARPHVLRALESVGWRFEDLDKHGKRVAVCSNCHVEYYFKDKKDVTFPWAKGVDVDSIEKYYDESQFTDWTHALSKAPMLKTQHPDFEVWSQGVHGKNGVTCIDCHMPKVKDKDGKVYTEHKIGNPFDRFDATCKTCHEQSKQTLQDRVKEHKAQVKEAMIRLEDQIVKAHFEAKVAWDAGATAEEMQDILMAIRHAQWRWDYSAAGHGNHFHAPDVMLHTIATGLDRVADARAKLGVVLTKHGVETPIVMPDISTREKAQKAVGIDIAKDQAAKDEFLRTVVPQWERQARERGLLPEVTPKSVTTPKVDAK
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: KIZ_DANRE
Sequence: MAFCNTEYFDQIGNIQKIIHERERRRHELEETLFSYLRSDERLTRLKCAKMRCYAKELHEREQRAKTRNLELLGNVENLASKLKEFSIDCSRLLQKRMEYKNHITRLKKDRRKMGSRGKSEADEHPSRLSTQGLSQSAAIFMGHQTSNGSSRNDGATTKRLPSHTEQIPNHPSLPPSQSGLCMHSHVSKASGAGILSDDILNSGDFLEGRRLSDVREKQMESDWDISQRAREQQRQEELKSPHTTLKEAEVSSRSVTVNKPADIVSLEHCPTRSPSPDTTDPSDASHYMNSGGEDEEESAEDKDDSAPINQNHSDYTSNILKPDTSMHSDSDDSASQSQSGHHASRGNALIQEQSIKAMQTHCGSKHKKVSTWQSGQHHFSESPNRLSMKGFCHLLKCIEQRLETEDVVNLYRISVNEQNLSDDIISICSQRGRLDDIDLHACGAVVLQQLSMLSCSLPHGCLLPSDLINSHWSTTSKPQQIRLCLSAESAVLWDCCFTHMVQLQKQKLLSTDHIIQLFTPLLLPADATYTDKAGKLLKRLLTYKSETHYPSKSESSSSSSLPSLLNDSVEIKPARPSGTNAQTGEEQEIQSAEEDSADQSPVESIPIRETKAYQLLKQSVAQERHWSDSEEEVSEPPDAHKLEKPEVQQDILTQNNRKSVKTKPFSAVQSKAFWGESDDSNSEIEMALRPQSCNTSSHDFDDFYD
What is the function of this protein?
Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation.  Required for stabilizing the expanded pericentriolar material around the centriole.
What are the official names of this protein?
Centrosomal protein kizuna, Polo-like kinase 1 substrate 1.
What is the protein family that this protein belongs to?
Belongs to the kizuna family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
Protein: YPEC_SHIFL
Sequence: MFRSLFLAAALMAFTPLAANAGEITLLPSIKLQIGDRDHYGNYWDGGHWRDRDYWHRNYEWRKNRWWRHDNGYHRGWDKRKAYERGYREGWRDRDDHRGKGRGHGHRH
What are the official names of this protein?
Uncharacterized protein YpeC.
What is the protein family that this protein belongs to?
To E.coli YaaX.
Protein: IF2_EHRCJ
Sequence: MNESKGAVDSGLMSGKTERTTLKLSDKLKLSSSIQQNTKFALNKSITTVEVRKSKKRRDIDNIEQASVVLQNDNVYQSDGDNNTLTIQEQISRMNALQNANIHEKKEEVSDDQTDKKEEVTNAETVGLLPVEENVNTDLVIEEGHSEKVEEVIEESVIEDQPNLEHLDVIEEKNGPNQSGDQNVDNSIVDLLQSKAVEEKKLKKYEKEHEEKKGNPKKGVSNHMYSKHVKLVIEEELEDNNKQIIQTHKTRKNRSVSSIKNKITRKVLIPKKITVQELASNMSERVKDVQNMLFQMGRRDIKPNDFLDSDQAAIIVEAFNHTFKLVNDGKLEDDLYSDGNDKELLPRAPVVTVMGHVDHGKTSLLDAIRESNVADGEFKGITQHIGAYQIILDGDKRITFIDTPGHEAFTAMRACGTNVTDIVVLVVAADDGIMPQTIESINHVKAANVAMIVAVNKIDKHDANLDKITNSLLNHGVVAESLGGDVIVVPVSAKEKINLDQLKSSILLMAELLELKAIYNTRASGVVIESKIDKNCGVVATLIVQKGTLKSGDIIVVGHNSYGKVRNMFNSDGRSQKVAIPSMPVKVLGLNNVPNSGSSFIVVDSEKQARELINYRQELFNASLEENAKSKMDASNILACDVVDELNVILKCDVMGSVEAICYSISKITHEDIKLNVLYKGVGNVTKSDVLLAETSNSIILAFNVKADAQVKELAKQRCVEINHYSVIYDIIDDVKRILSSMLKPLQQEVQVGALAIRKVFSSGNAGSVLGCYVTSGVVKKGSLVKLIRNNTIIHEGKIKVLRRFKDDVKEVSSGFECGILLDYSKEIYPESDIINVLEVIEEVRVIK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H1A02_CYRHA
Sequence: MKASMFLALAGLVLLFVVCYASESEEKEFPRELISKIFTVDDFKGEERECKGFGKSCVPGKNECCSGYACNSRDKWCKVLLGK
What is the function of this protein?
Weakly blocks the rat SCN2A/SCN1B (Nav1. 2/beta-1) sodium channel (IC(50)=68 uM) and the insect sodium channel para/tipE (IC(50)=4. 3 uM), without altering the activation or inactivation kinetics (depressant toxin).
What are the official names of this protein?
Mu-theraphotoxin-Hhn2b 2, Mu-TRTX-Hhn2b, Hainantoxin-I, HnTx-I, Peptide F5-19.03.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 14 (Hntx-1) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPAB1_ASHGO
Sequence: MDQDNERNVSRLWRAFRTVKEMVRDRGYFITQEEVDLSLEDFKAKYCDSMGRPQRKMMSFQSNPTEETLKKSPNMGSVWVEFCDEPSVGIKTMKNFVIHIGEKNFQTGIFIYQNGITPSALKLLPSVAPATIETFNETALVVNITHHELVPKHIKLSDEEKKELLKRYRLKESQLPRIQRMDPVALYLGLKRGEVVKIIRKSETSGRYASYRICL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  Pols are composed of mobile elements that move relative to each other.  In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template.  Seems to be the major component in this process (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I, II, and III subunit RPABC1, RNA polymerases I, II, and III subunit ABC1.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RR3_RANMC
Sequence: MGQKINPLGFRLGTTQSHHSVWFAQPKNYSGGLQEDKKIKDCIKNYVQKNRKISSGVEGIARIKIKKRIDLIQVIIYMGFPKFLEGNPQGIEELQSNIQKEFNSVNQKLNIAITRIAKPYGQPNILAEFIAGQLKNRVSFRKAMKKAIELTEQADTKGIQIQIAGRIDGKEIARVEWIREGRVPLQTIRAKIDYCSYTVRTIYGALGIKIWIFAGEE
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PLSB_SALHS
Sequence: MSGWPRIYYKLLNLPLSILVKSKSIPAEPAQELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGALLPRYVFIHGGPRVFTYYTPKEESVKLFHDYLDLHRSNPALDVQMVPVSVMFGRAPGREKGEDNPPLRMLNGVQKFFAISWLGRDSFVRFSPSVSLRRMADEHGTDKIIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASKAIARAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLVPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLKGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPEWRESIDPIEAIRPAWLTPTVNSIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLDCYLDLMRNVPYSTDSTVPAASAGELIAHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLIMPSLMAAIITQHRRISRDALQQHVEALYPMLKAELFLRWEREELASVIDALASEMQRQGLITLQDDELHINPTHSRTLQLLAAGARETLQRYAITFWLLSANPSINRSTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDTGDAEPAETMKIYQMLADLITSDVRLTIESATQGE
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: POLG_BECNB
Sequence: MAPVVSRDQCKPKTPKPHRPAPPHRCTTRCPEDCGWYVGRCSCPNVCQREGWDDFFVADKVKPPSYVASKTSVADVVDWLLEEDPATDGPSEFDLTQFFQAYTDKSHQIHRDYAPDQLAQALDMAYILSVDPPDIKLPEYEATRFTHDTSYKGKLPKWLRVYGIKSRELAKKAVTNIRGGAHWAKGLFKQMWDSLPGWSEVEAYFKAFFAGIITGVEDALSKSPSSVWTSLKLTPLLYIWRNINECSDIAVILGAFWATLELYNIPSKVYDLVSTALGPMVQELARKVINVVKGDGSGPKQEGGRPSFSIPGVLLATFLSAIILGSMPSDGLIKKILRGCATAAGLVGGFNAVKSIITTVQGASACKDVKKLASQLMCVTTMAATVSTRGERQVLASMLNDLNESVRERLVDPAYASLVPQLSAMSNKIVELSTMNASALSAARKRTPAKIIVLCGPPGHGKSVAAHKLAKMLNPNEPSIWNPFSDHHDEYTAEEVMVIDETPAEPGQWIEDLIAMGSNSPFVPNYDRVENKTRCFDSKYVIITTNHNPLINPTHTRAAALARRLTLVYVNSPDVADFLRQHPGVPPPATLFKADCSHLHFDIHPYNSIGTTAIVGHNGTTPVPRAKRVSLEGLCKHVKEMPDREGPPDGVPERMVLVAPDKGTARFVEAVINTYHNSGLVAQPAAWDTTPQPYQLAVTWQGSNSTVTGQRWDCNPQTPFVAPHFTRNMFKRVLGTEVPEYHLLAYACRITSSSLGDKSLPVPNPTVVINDPSPTRLALALMRHLKNPIASGLRVVWDLFRGCATGPKRLFTWALSQEWNPMPVTTAFTFPAGTVILHTAGGVRVVVLPPGPQFGLTEVARLADHSGQDDPVVPDMFGATWTELLWRLLKVIGTFLANYGVAIAGLTLSIAAFKTANKSAKNDRQGWLSGSGVALSDEEYDEWMKYSKKKGKKINADEFLQLRHRAAMGNDDDDARDYRSFYTAYQLGREGNNCDDIPLHPAVGPTTGGGYYVHIGNGVGVTLKHVASGEDVIKELGNDLVKIRTKHHKVGDPAMVVGDGMPVKFVTGHLVVDTRSESVVFDQTRLNVIRVKVPGLETRRGYCGLPYVNSAGQVVGLHQGSYGVGDKVITPITPEPTAPPDTIMWRGLECARSDIVTHLPHGTKYSVSPGMKEEATKCSHQPAPLGRNDPRCGQTQVAMVVKALSPYTGSPAVEKLDGCLVAAISEVRTAIQSLTPKGGFRPLTFAAAWQSLDLSTSAGALAPGKTKRDLCDPDTGMPTGKYKEELLRAWSRAGTGTALDHTYIVALKDELRPVEKVAEGKRRLIWGADARVALIASAALSPIANALKTVTNLLPVQVGVDPSSASCVSAWVNRLNRHDHCLELDYSKWDSTMSPVLINIAIDILCNTCASDGLRVAVCQTLKTRPTALVEGVAVPTKSGLPSGMPFTSQINSIVHWILWSATVRKCSLPLNIGSVNELAPFLTYGDDGLYTIPSHLTKSIDEIVSTLKGYGLSPTAPDKGMNIEIKKTSFTYMSGPVFLKRRIVLTPGGHRALLDLTSLARQPVWVNGPRRSVWDHEAQPIEIDSEVRTIQLQNVLIESAWHQPQDFNQVAALVYKSAEASGITIPRYSLEEARAIYDGRFYGIQHVSMPCNSDLIREGNMSDNKSIPEQQHESSRAMDAGATGAAAAAPAPPVAAAPASGLVGALVAEPQSGPSTEQWRTAYTLFGTVSWNANAGPGTILTVGRLGPGMNPYTQHIAAMYGGWAGGMDIRITIAGSGFIGGTLAVAAIPPGVDPESVNVLRMPHVLIDARGGVPLEVTLEDIRTSLYHPMGDANTASLVIAVMTGLINPLGTDTLSVTVQLETRPGRDWVFFSLLPPTAGVASADPSQLLTRVALATSPEVRFGTGVLGILGLPSNPSVNRVYDVQSRTRGWSFPIPSSSVFMGDARNVEHTRRVMVQSSAPNNPLSDVFPDGFPDFIPQSDTEPDGGAVIAGQVLPHPGDNDNFWRLTPVVRGNTTAAINTIPERFNQVYFINLADEEAVSAATEELRFNGIQGIFGQRTTARAVQVMQGYVPRAEHIIRPAGFAGVGPQGPNVPIGFAGTMPNFNATASGADDLVPVWGPTLVHTASLLAGTTYELAENSMYVFSVSTSTSTFELGMLANGTWLGPAQLAGTGITWTEVLSVTYMGMRFAYNPLSGQGIGGESRRL
What is the function of this protein?
Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins.  A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry.  The capsid encapsulate VP2 proteins and genomic or subgenomic RNA.  Attaches virion to target cells inducing endocytosis of the viral particle.  Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).
What are the official names of this protein?
Genome polyprotein.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm.
Protein: DISA_BACC1
Sequence: MEENKQRVKSMINILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCAFSPASLYELAKMDGALILNETGSKILIANAQLVPESSIDSIETGMRHRTAERVAKQTGSLVVAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFEEVVTMSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKDYYQEKTQDHHQILKKLQELANTQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCRATINELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: THIM_LISMH
Sequence: MFDFMTLEKVREKGPLVHNITNIVVANDSANGLLAIGASPIMASAKEEMDELAKMADVLVINIGTLDGELVEAMKIAGRAANVAGTPVVLDPVGVGATSYRRKVVQELLAEIQFTAIRGNAGELAAIAGEAWEAKGVDAGVGSADVLSIAEKVANEWSTVVIISGEVDVISDGTRFAKVANGSALLPRITGSGCLLSAVCGSFIAVQDDAFRASVEACASYAVASEYAELELERKLPGSFRPLFLDALASWSVEKTHAKAKIQESGEHK
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: TRMB_ASPCL
Sequence: MTPPPAKRQKRNEYRKANTAVADDASEIRLPQKKFYRQRAHANPFSDHQLNYPLSPAHMDWSSHYPAFVDPEPSHTNLAGTRKLLKDVEVVDIGCGFGGLLIGLAPLLPESLIVGMEIRVSVLEYVTARIQALRSQQQKLRSSAIPSESSPAAQQPQQHHQQQLQATETAADAASPSSPDATGETLSLVPGNYQNISAIRSNTMKFFPNFFARHQLSKIFICFPDPHFKARKHKARIISETLNAEYAYALRPGGLLYTITDVEEYHHWVLRHFGEEGADAGQNAGVTELFERVSDEELEKDDCVRVMKEATEEGKKVTRNKGNKYVAVFRRKADPEWPA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IRF3_PIG
Sequence: MGTQKPRILPWLISQLNQGQLEGVAWLDEGHTRFRIPWKHGLRQDAQQEDFGIFQAWAEASGAYTPGKDKPDLPTWKRNFRSALNRKEALRLAEDHSKDPHDPHKIYEFVTSGVGDFPEPDTSLDLSGRYSTSDTHEDSLDKLLSGMDLASDAGPQSLTLALEQPPQLSLSPSVDAPASCPNLGVRENPLKQLLANDDEWEFQVTVFYRGCQVFQQTVCSPGGLRLVGSEAEDGTLAGQPVRLPDPAASLTDRGVADYVRRVLSCLGGGLALWRAGQWLWAQRLGHCHVYWAMGEELIPDSGHKPDGEVPKDREGGVFDLGPFIEDLIAFIEGSRRSPRYTLWFCMGQSWPQDEPWVKRLVMVKVVPMCLRALVDMARDGGASSLENTVDLHISNSHPLSLTSDQYKACLRDLVEDMDF
What is the function of this protein?
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses.  Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.  Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction.  Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases.  This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes.  Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
What are the official names of this protein?
Interferon regulatory factor 3, IRF-3.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection.
Protein: Y9560_DICDI
Sequence: MVLICGNQRKKFALCPKGSLIFFKGGFKYILIWDESKIGKISSELLQFISN
What are the official names of this protein?
Putative uncharacterized protein DDB_G0267802.
Protein: DEOB_ALIF1
Sequence: MKRAIILVLDSFGIGAAGDADKFGDVGSDTMGHIAEQCDKGLADNGNRKGPLTLPNLSKLGLAMAGKESTGKFSAGLDANAEIIGAYGHAAELSSGKDTPSGHWEIAGVPVLFDWGYFTDKENSFPKELTDRILERANLPGYLGNCHASGTQVLDDLGEEHMKTGMPIFYTSADSVFQIACHEETFGLDNLLTLCQIAREELEDYNIGRVIARPFIGPGKGQFERTGNRRDLSVEPPAATILQKLVDEKGGQVHSIGKISDIYAGCGITKKTKATGIPALFDATKEAIEQAIEQAGDNTIVFTNFVDFDSAYGHRRDVAGYAAALEYFDGRLPEIMDMLQEDDILILTADHGCDPTWPGTDHTREHIPVLVYGHKVPAGSLGRRDTFADIGQTLAEYFETSDMEYGKSFL
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_VIBA3
Sequence: MEQLIRDEMRVLPSIDPHFEVTRRVEFIKTKLQQSGCKSLILGISGGVDSTTCGRLAQMAVDSLNESAGSDEYQFIAVRLPYGEQKDEDEAQLALSFIQPSQSVSVNIKAGVDGLHAASHVALEGTGLLPTDSAKIDFVKGNVKARARMIAQYEIAGYVGGLVIGTDHSAENITGFYTKHGDGACDLAPLFGLNKRQVRELAATLGAPEQLVKKVPTADLEELDPQKADEAALNLSYDQIDDFLEGKAVSQDVSDRLVGIYKATQHKRQPIPTIYD
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: HYPA_CROS5
Sequence: MHELGITQNIVAIVLEQARGASVKRVTLEIGKLSAIMPEAIRFCFDICCQDTLLEGVTLEIIETEGKGKCRHCGHEIRLSQPFGQCDRCDSFELDIIQGQELQIKEMEVEELCV
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: LDHB_SCEWO
Sequence: MASLKDKLITPVAQPATQPTSKVTVVGVGQVGMACAISVLEKGLCDELALVDVLEDKLKGEMMDLQHGSLFLKTNKIVAGKDYAVTANSKVVVVTAGVRQQEGESRLDLVQRNVNVFKFIIPQVVKYSPDCIILVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRFLMGERLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPAMGSDQDSEGWKQVHKQVVDSAYEVIKLKGYTNWAIGLSVADLLETIMKNLCRVHPVSTMVKGMYGIENEVFLSLPCVLGSVGLTSVINQKLKDSEVAQLQTSATTLWNVQKDLKDL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase B chain, LDH-B.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_ACTPJ
Sequence: MKAQELRNKNVEELNAELINLLGEQFKLRMQAATGQLQQTHQLKQVRRSIAQVKTVLTEKAGE
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: OR5MB_HUMAN
Sequence: MSNTNGSAITEFILLGLTDCPELQSLLFVLFLVVYLVTLLGNLGMIMLMRLDSRLHTPMYFFLTNLAFVDLCYTSNATPQMSTNIVSEKTISFAGCFTQCYIFIALLLTEFYMLAAMAYDRYVAIYDPLRYSVKTSRRVCICLATFPYVYGFSDGLFQAILTFRLTFCRSSVINHFYCADPPLIKLSCSDTYVKEHAMFISAGFNLSSSLTIVLVSYAFILAAILRIKSAEGRHKAFSTCGSHMMAVTLFYGTLFCMYIRPPTDKTVEESKIIAVFYTFVSPVLNPLIYSLRNKDVKQALKNVLR
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 5M11.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ASTE_YERPG
Sequence: MLDFLAITLSGKPPQVIQGETVNLKWQWLGEGILTLVPHRSYTQSVVISAGIHGNETAPIEILNQLVTDLLAGQLPLSVRLLVLLGNPPAIRKGKRYLSNDINRMFGGRYQHYTPSDETRRASTLEQRVMAFFQASHTSERLHYDLHTAIRGSYHPRFGLLPYQQTPYSAAMFRWLRDIELDALVMHTSAGGTFAHFSSERCQAASCTLELGKALPFGENQLSQFSAITQGLRSLVSDSALPARKTENMKYYRVVKSLLRQHPDFKLRVAEDTVNFTRFAQGTLLTEQPNDNYRVEHPYEWILFPNPHVALGLRAGMMLVKMCESELPIT
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: UNG_BORHD
Sequence: MEVKIEESWKEILKAEFCKGYFKRLVNFIKNEYKTKKGKIFPPPKLIFNAFDSLPFKDIKVVILGQDPYHGKRQANGLAFSVNSDIKIPPSLQNIFKEIERSLKIQTIPNGDLTRWATQGVFLLNSILTVEESRPSSHKDIGWEIFTNEVIKIISKNLNNIVFMLWGNFARGKKELIDASRHLILETSHPSPYSAHNGFLGSNHFSQALRYLKEHNKSPIDFQ
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_LIMRJ
Sequence: MATKKGTRKRRAKKNVETGVAHIHSTFNNTLIMITDVQGNAVAWSSAGVLGFKGSRKSTPFAAQMASEAAAKQAMEHGMKTVEVEVKGPGSGREAAIRALQATGLEVTAIRDVTPVPHNGSRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RL33_DEHM1
Sequence: MAKKTDTRIVINMACTDCGERNYTTEKNKRNDPRRIELNKYCPRCREAKVHRETK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.