PharMolix/UniProtQA huggingface dataset:
Protein: TGT_RALSO
Sequence: MLNFDLLTTDGLARRGRMTLNHGVVETPIFMPVGTYGAVKAMSPVELKDIGAQIILGNTFHLWLRPALEVIDAHKGLHGFVGWDKPMLTDSGGFQVFSLGDLRKITEEGVHFASPINGDRLFLSPEISMQIQRRLNSDIVMQFDECTPYQIDGRPATEAEAAASMRMSLRWAQRSRNEFERERNPNALFGIVQGGMFEPLRDESLAGLQAIDADAGGQGFGGYAIGGLSVGEPKEDMIRVLQHVAPRLPANKPHYLMGVGTPEDLVAGVAAGIDMFDCVMPTRNARNGWLFTRFGDIKIKNAVHRNDPRPLDETCGCYTCRNFSRAYLHHLQRVGEILGARLNTIHNLHYYLELMADMRTAIESHSFAVFRARFAADRARGAL
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: URE2_ECO57
Sequence: MIPGEYKVKPGYIELNIGRATCSIIVENHGDRPIQVGSHYHFAEVNPALKFDRQKARGYRLNIAAGTAVRFEPGQKREVELVALSGARIVHGFRGDIMGELEANDE
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_CHLCV
Sequence: MTFELRAAFAPCGDQPEAIAKLTQGIRNDVQSQVLLGTTGSGKTFTIANVVANVNRPTLVLAHNKTLAAQLYQEFKEFFPNNAVEYFISYYDYYQPEAYIARNDTYIEKSLLINSEIDKLRLSATRSILERRDTLIVSSVSCIYGIGSPENYASMALELKVGKEYPRTLLAAQLVKMNYQASPVAQRSTFRERGSVIDIFPAYESDQAIRLEFFNDTLSSIEYSDPLTMIPTASVASTIIYPGSHYVTPEAVREQAICSIREELEERMLFFHDRPVEQDRLFHRTTHDIEMIKETGFCKGIENYSRHFTKMPPGAPPACLLDYFPEDFLLVIDESHQTLPQIRAMYRGDLSRKQSLVEYGFRLPSAYDNRPLTYEEAQKYFHNVIYVSATPGETELNESQGHIVEQIIRPTGIPDPIPEIRPATGQVDDLLEEIRKRLSKSQEKILVISITKKLAEDIAAFLSELDIAAAYLHSGIETAERTRILADLRLGNIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAARNVEGKVIFYADQKTRSIEQTLKETERRRQIQLDYNKANNITPKPIIKAIFANPIPQGGKKESQEPAKTPLSIKELEKLIKKFENLMQEAAHEFRFDEAAKYRDKMKAAKEQLLYLS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_NEIMB
Sequence: MGDSVLSAIQQTITQRKSANPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKNPSHLVYEVADLWFHTMILLTHHDLKAEDVLDELARRQGLSGLVEKAARTES
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB1_SYNAS
Sequence: MEFEAVIGLEIHIELNCPTKLFCDCPNNPGDEPNVNTCPICLWFPGAIPRLSQAALEKASLLCLGLGAELQPRSAFDQKVYYYPDLPKGYQLSQAHLPLARGGGIDITDENGRPKRLRIHHIHMEEDVAKLVHEIEGRTPISLVDFNRAGAPLVEIVSEPDFRTPHDAMEFLKALRTQVRYVGASECSMENGTMRVDANISVRPRGTDQMNTKVEVKNMNSIRHVGDAVAYEISRQSACVSSGEAVVLHTRLWDPDRKATFPMRAKFEGPCVPDPSVPFIDLSPEWIEKMRARLPEMPAARAERFVARYGLTDEEAVYLSADPETASYFEALIAEKVAPRTAMHWLTTQLLAAVRERGQELSGTPVTPARFAALLKMLAKDEINANAARQVLIELFDCGESPEKIVEARGIRQVSDHDALEGLIDRVLGENPAAVADYRGGQGKAAGFLIGKVMQASGGKANPKIIRELLTKKLDALG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B 1, Asp/Glu-ADT subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: YEFM_MYCBO
Sequence: MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSVDELREMAGGEE
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  A probable antitoxin for the putative mRNA interferase YeoB (By similarity).
What are the official names of this protein?
Antitoxin YefM.
What is the protein family that this protein belongs to?
Belongs to the phD/YefM antitoxin family.
Protein: SECA_THET8
Sequence: MLGLLRRLFDNNEREIARYYKQVVEPVNRLEAEVEKLPDLAAAYRELKEKHEKGASLDELLPMAFALTRESAKRYLGMRHFDVQLIGGAVLHEGKIAEMKTGEGKTLVATLAVALNALTGKGVHVVTVNDYLARRDAEWMGPVYRGLGLSVGVIQHASTPAERRKAYLADVTYVTNSELGFDYLRDNMAISPDQLVLRHDHPLHYAIIDEVDSILIDEARTPLIISGPAEKATDLYYKMAEIAKKLERGLPAEPGVRKEPTGDYTVEEKNRSVHLTLQGIAKAEKLLGIEGLFSPENMELAHMLIQAIRAKELYHRDRDYIVQDGQVIIVDEFTGRLMPGRRYGEGLHQAIEAKEGVRIERENQTLATITYQNFFRLYEKRAGMTGTAKTEEKEFQEIYGMDVVVVPTNRPVIRKDFPDVVYRTEKGKFYAVVEEIAEKYERGQPVLVGTISIEKSERLSQMLKEPRLYLPRLEMRLELFKKASQKQQGPEWERLRKLLERPAQLKDEDLAPFEGLIPPKGNLRTAWEGLKRAVHTLAVLRQGIPHQVLNAKHHAREAEIVAQAGRSKTVTIATNMAGRGTDIKLGGNPEYLAAALLEKEGFDRYEWKVELFIKKMVAGKEEEARALAQELGIREELLERIREIREECKQDEERVRALGGLFIIGTERHESRRIDNQLRGRAGRQGDPGGSRFYVSFDDDLMRLFASDRVIAMLDRMGFDDSEPIEHPMVTRSIERAQKRVEDRNFAIRKQLLQFDDVLSRQREVIYAQRRLILLGKDEEVKEAAIGMVEETVASLAENFLNPEVHPEDWDLEGLKATLLDTAPQLQDFPFAELRALKAEEAVERLVEAALKAYEAREAELSPPLMRAVERFVILNVVDNAWKEHLHNLDVLRQGIFLRGYGQKDPFQEYKIEATRLFNEMVAFIKSEVAKFLFRLKVEAEPVRPVREAPYVPVPEAKPEPSEVFGVERKRATPPPQPGLSRAERRRLMRQEKKRKK
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RL14_CHLTB
Sequence: MIQQESQLKVADNTGAKKVKCFKVLGGSRRRYATVGDVIVCSVRDIEPDSSVKKGDVVKAVIVRTRNDIHRKDGSTLRFDTNSCVIIDDKGNPKGTRIFGPVAREIRDRGFVKISSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: HPRK_LEPBP
Sequence: MPVPGITVETILRDHDDLQLQLVTGEVGLSNRINSAEINRPGLSLTGFFDFFANDRIQILGKGEWAYLNSLSEEKLGEITDKFFEFHLNCIIYTHGNEPQVPFVERAKEKGIPLFKTEIATHRFITLISQILDRALAPRTMRHGVLIEVFGIGTLLTGRSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGSCSDLLRHHMEIRGLGILNIKDLFGVGSVRDHKLIELIINLKEWEEQTSGDYERTGIEQSMEEILGVSVPYIEIPVKPGRNIPIIVETAAMNQRLRKMGKNSAKEFSNKLNTYIQQSSIETNPIKD
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: BCAP_HUMAN
Sequence: MAASGVPRGCDILIVYSPDAEEWCQYLQTLFLSSRQVRSQKILTHRLGPEASFSAEDLSLFLSTRCVVVLLSAELVQHFHKPALLPLLQRAFHPPHRVVRLLCGVRDSEEFLDFFPDWAHWQELTCDDEPETYVAAVKKAISEDSGCDSVTDTEPEDEKVVSYSKQQNLPTVTSPGNLMVVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSPSVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETVISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKSHIKEELMHGEEADAVYESMAHLSTDLLMKCSLNPGCDEDLYESMAAFVPAATEDLYVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVYHTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGVYESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRAASQRPPTRETFHPPPPVPPRGR
What is the function of this protein?
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway.  Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1.  Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production.  Also involved in the activation of PI3K in natural killer cells.  May be involved in the survival of mature B-cells via activation of REL.
What are the official names of this protein?
Phosphoinositide 3-kinase adapter protein 1, B-cell adapter for phosphoinositide 3-kinase, B-cell phosphoinositide 3-kinase adapter protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: GREA_AGRFC
Sequence: MVEKVPMTQGGFVKLQEELRFRQQEERPRIIEAIAEARAHGDLSENAEYHAAKEAQSHNEGRITELEDLTARAEVIDLSKMSGSKIKFGATVKLIDEDSDEEKTYQIVGDQEADVKAGRISISSPIARALIGKEVGDSIEVNAPGGAKGYEILAVQWG
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TRPD_PSEAE
Sequence: MDIKGALNRIVNQLDLTTEEMQAVMRQIMTGQCTDAQIGAFLMGMRMKSETIDEIVGAVAVMRELADGVQLPTLKHVVDVVGTGGDGANIFNVSSAASFVVAAAGGKVAKHGNRAVSGKSGSADLLEAAGIYLELTSEQVARCIDTVGVGFMFAQVHHKAMKYAAGPRRELGLRTLFNMLGPLTNPAGVRHQVVGVFTQELCKPLAEVLKRLGSEHVLVVHSRDGLDEFSLAAATHIAELKDGEVREYEVRPEDFGIKSQTLMGLEVDSPQASLELIRDALGRRKTEAGQKAAELIVMNAGPALYAADLATSLHEGIQLAHDALHTGLAREKMDELVAFTAVYREENAQ
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: NGBR_MOUSE
Sequence: MTGLYELVWRVLHALLCLHLTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPRAVGRNRRHHRHPHGGPGPGPGPAATHPRLRWRADVRSLQKLPVHMGLLVTEEVQEPSFSDIASLVVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELLGQDCSKYSAEFANSNDKDDQDLNCPSAVKVLSPEDGKADIVRAAQDFCQLVAQQQRKPTDLDVDLLGSLLSSHGFPDPDLVLKFGPVDSTLGFLPWQIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLGK
What is the function of this protein?
With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery.  Both subunits contribute to enzymatic activity, i. e.  condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).  Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length.  Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.  Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.
What are the official names of this protein?
Dehydrodolichyl diphosphate synthase complex subunit Nus1, Nogo-B receptor, NgBR, Nuclear undecaprenyl pyrophosphate synthase 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis.
Protein: SYDND_NATPD
Sequence: MENRTYTADAEPGETVTVAGWVHEVRDLGGIAFLILRDTTGQIQVKFEKDEMDDELVETGLNVARESVITVSGDVEEEPRAPTGVEVTPETVEVLSEADTELPLDPTGKVDAELSTRLDNRTLDLRSEEGQAIFEIRAEVLRAVREAFRDANATEINTSKIVATGTEGGTELFPITYFGEEAFMNQSPQLFKQLVAGSNIERVFEIGPIFRAEEHNTPRHLNEATSIDFEGAFCDHTDAMDVCEQVVTAAYEAVAENCTDQLEALGITEEFEVPETPFPRLSYEEAIERINATGELDEQLVWGDDLPTEGEKALGDDVGGHYFITDWPAEIKPFYIMDHEDGELSTGFDMMHPRMELVSGGQREHRREELIAGFEQQGLEPEAFEYYTKMFKYGMPPHAGWGLGGERLLMTMLDLDNIREAVLFPRDRQRLSP
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALC_PIG
Sequence: CSNLSTCVLSAYWRNLNNFHRFSGMGFGPETP
What is the function of this protein?
Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
What are the official names of this protein?
Calcitonin.
What is the protein family that this protein belongs to?
Belongs to the calcitonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PANC_PARXL
Sequence: MKVISSIHELRDQLRGQNRTAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTMEADIEKLQKENVYVLFAPTEKDLYPEPQEYRVHPPHDLGDILEGEFRPGFFQGVCTVVMKLMSCVQPRVAVFGKKDYQQLMIVRRMCNQFALPTDIIAAETVRDADGLALSSRNRYLQAAERAEAPRLAAELNQVREAVLGGERDFAKIERAAMAALAARGWQPDYIAVRKRSNLLPPGPEDANAELVVLAAARLGATRLIDNLEI
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C71BD_ARATH
Sequence: MSLWYIIVVFVFFASIFIAKNTRKTKKNLPPGPPRLPIIGNLHQLGSKPHRSMFKLSEKYGPLVYLKLGKVPSVVASTPETVKDVLKTFDKDCCSRAFLTYPARISYNLKDLAFAPYSKYWKAVRKMTVVELYTAKRVKSFRNIREEEVASFVEFIKHSASLEEIVNLNQTLVKLSGSVICRVGFGINLEGSKLENTYEEVIHGTMEVLGSFAASDYFPVIGGIIDRITGLHNKCEKVFKGTDSFFDHCIKHHLEDGGSKDDIVDLLLKVERGEIGLGEFQFTRNHTKGILLDILLAGVDTSGHTITWVMTHLIKNPRVMKKAQAEVREVIKNKDNITEEDIEGLEYLKMVVKETLRINPLVPLLTPREASKDVKIGGYNIPKKTWIHVNIWAIHRNPNVWKDPEAFIPERFMDNQIDYKGLNFELLPFGSGRRICPGIGMGMALIHLTLINLLYRFDWKLPEGMEVEDVDLEESYGLVCPKKVPLELIPVLTQWT
What are the official names of this protein?
Cytochrome P450 71B13.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RIBA_HELPS
Sequence: MKRLEVSNQAKLPTQFGEFCIQCFREKGSNGSKEHLVVFTPNFSQNPLVRLHSECLTGDALGSQKCDCGGALQIALERISKEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKDDERDYSIAGEILEYYGIKKMRLLTNNPKKIAALEKYAEVTRESLIVCANEHNQGYLEVKKLKMGHLL
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: MAP2_NEUCR
Sequence: MAAQAAPAEELSKLSVDETKPAPAAANGNDSDAESGDEEAEEGAAAPAAGAAKKKKKRKPKKKKKAPTSQSEPPRVLVSQLFPNNQYPKGEEVEYVNDNLNRVTNEEKRHLDNLNQEFLTDYRHAAEVHRQVRQWAQKSIKPGQTLTEIAENIEDSVRALTGHSGLEEGDALIAGMGFPTGLSINHCAAHYTPNAGNKMVLQEDDVMKVDFGVHVNGRIVDSAFTVAFNPRYDPLLEAVKAATNAGIKEAGIDVRVGDIGAAIQEVMESYEVEINGQMLPVKSIRNLNGHTINHYSIHGTKSVPIVKSNDQTKMEEGDVFAIETFGSTGNGYVHEEGEVSHYAKRGDAAKVDLRLSSAKSLLNVITKNFGTLPFCRRYIDRLGQDKYLLGLNNLVSQGIVEAYPPLVDKKGSYTAQYEHTILLRPTVKEVISRGDDF
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_SYNJB
Sequence: MEWLSQPAPLVAPALLGMVLVRQFADGLQVRAQIVETEAYTAGDPACHAYRRKTQRNQVMFGPPGHLYIYRIYGLYHCLNIVTEPEGIPAAVLIRAAQLDRLPDWIPANKQNQPARAAAGPGLLCQALRIDGSHNGWRLERAEAGQEGIWLEGSPSWQTQLSIVQTTRIGITQGAEIPWRWYIGGHPAVSRY
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: BIOB_PROM5
Sequence: MINSDNQKFSKIRFDWARDEILEILNYPLVDLMWEAQIIHRRFNEYKVQLASLFSVKTGGCEENCSYCSQSIYSSSQIKSHPQFEVEAVLNRAKTAKKEGADRFCMGWAWREIRDGKPFNSMLEMVKGVKELGMEACVTAGMLTDEQALRLADAGLTAYNHNLDTSPEYYKNIITTRTYQDRLETIKRVRNAGINVCCGGIIGLGENNGDRASLLEVLSNMNPHPESVPINSLVAIEGTGLEEKKEIDSIEMIRMIATARILMPKSKIRLSAGREKLTKEAQIICFQCGANSIFYGDELLTTSNPSFQDDRKLLKDVGVLFNKDFEYCDKTVSTV
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: RL32_ICTPU
Sequence: MAALRPLTKPKIVKKRTKKFIRHQSDRYVKIRRNWRKPRGIDNRVRSGFKGQMLMPNIGYGSNKKTKHMLPSGFKKFLVHNVKELEVLLMSNKSYCAEIAHNVSSKNRKVIVERAAQLAIKVTNPNARLRSEENE
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUO8_SOLTU
Sequence: VHMARNMXVPPXXAD
What is the function of this protein?
Transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase 12 kDa subunit, Complex I-12kD, CI-12kD.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: HIF1N_DANRE
Sequence: MAETDGAAAFTELRDPDWDESQLRQYTFPTRQIPRLSHTDPRAEVLINNEEPVVLTDTSLVYPALKWDIPYLQENIGNGDFSVYIAENHKFLYYDEKKMVNFQDFVPKSRRIEMKFSEFVDKMHQTEEQGGKGRVYLQQTLNDTVGRKIVVDFLGFNWNWINKQQAKRNWGPLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGHKRCILFPPDQFDCLYPYPVHHPCDRQSQVDFENPDYDKFPNFKNAVGYEAVVGPGDVLYIPMYWWHHIESLLNGGETITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGDPHEVGPLLNMMIKGRYDHGLS
What is the function of this protein?
Hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha.  The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators.  Also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins.
What are the official names of this protein?
Hypoxia-inducible factor 1-alpha inhibitor, Hypoxia-inducible factor asparagine hydroxylase.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region.
Protein: MYP0_HORSE
Sequence: MAPGAPSSSPSPILAALLFSSLVLSPAQAIVVYTDKEVYGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPQWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLVLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDTSKRGRQTPVLYAMLDHSRSTKAASEKKAKGLGESRKDKK
What is the function of this protein?
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system.  It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
What are the official names of this protein?
Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero.
What is the protein family that this protein belongs to?
Belongs to the myelin P0 protein family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CS1F2_THETK
Sequence: MDEVLLLTGGISITTRALRALLATGATVAVFSPRGEPLGIFMRPVGDATGAKRRCQYKAAEDGRGLQYAKSWVFKKILGQRDNIKAWRRRLRGYSQYAESLAKALPGAGLHGAMETPRRRRRGQDGGQAGVRGRPTHPPVPPGAGRRSPGGAPRGQEASLRRDPQRGQSSGALHMYVIVVYDITENDVRAKVADILRAYGLARIQRSAYVGRLPPALVKELAERLARAVRGANADIAIFKVDKRTIDTSLRIPPRPPAGHVALH
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
What are the official names of this protein?
CRISPR-associated endonuclease Cas1/endonuclease Cas2 fusion.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the CRISPR-associated endoribonuclease Cas2 protein family.