PharMolix/UniProtQA huggingface dataset:
Protein: CD63_MOUSE
Sequence: MAVEGGMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENIPGMAKDRVPDSCCINITVGCGNDFKESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSIRSGYEVM
What is the function of this protein?
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades.  Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases.  Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2.  Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2.  Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes.  Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking.  May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
What are the official names of this protein?
CD63 antigen.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, extracellular exosome. Cell surface. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.
Protein: CRCB1_LEIXX
Sequence: MTPLVVLAVAIAGGLGAVARLVLDGVLRSRAPVSFPLGTTAINVTGSFVLGLVTALALGHGLPPEWRAILGTGFIGGYTTFSTASYEAVRLAQQRQYRAALLTGVGMMFLALGAAGLGLWLGGLAVAPTPPAPSTTL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NAP1B_TOBAC
Sequence: MSNTKDNFNVADLTAALNAGDRADLVNVLKNKLHDLTGKHSNVTESLSPNVRKRVEALREIQTEHDELEAKFFEERAALEAKYQKLYQPLYTKRFEIVNGVVEVDGATTEAAAADKQEDKDAVEKGVPDFWLTAMKNNEVLAEEITERDEEALKFLRDIKWSRIDDPKGFKLDFFFETNPYFKNSVLTKTYHMIDEDEPILEKAIATEIEWYPGKCLTQKILKKKPKKGSKNAKPITKTEQCESFFNFFSPPQVPEDEEDIDEDAAEELQNLMEQDYDIGSTIRDKIIPHAVSWFTGEAAEDDYAELEDDEDEDDDEEDDEDEDEEEEDEEDDEDEEEDEDETKTKKKTSAVPKKSGRVPAAADGQSGERPPECKQQ
What is the function of this protein?
May modulate chromatin structure by regulation of nucleosome assembly/disassembly.  Could function together with B-type cyclins in the regulation of microtubule dynamics.
What are the official names of this protein?
Nucleosome assembly protein 1;2, NtNAP1;2, Nucleosome assembly protein 1-like 2, NtNAP1_L2.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: PTH_PSEP1
Sequence: MTAIQLIVGLGNPGPEYEQTRHNAGALFVERLASAQRVSLTADKKYFGLTAKFSHQGNDVRLLIPTTYMNRSGQSVAALANFFRIKPEAILVAHDELDLPPGVAKLKRGGGHGGHNGLRDIIAQLGNQNDFHRLRLGIGHPGDAKLVSNFVLGRAPRAEQEKLDASIDFALGVLPDVLAGDFAKAMRELHSQKA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPD_XYLFT
Sequence: MDKTLVSAIEDAFARYSTLTVEEIEDSIRPTVNRVIDGLETGAFRVAEPDNHGGWKVNEWLKKAVLLYFRVHDTTIVDAQPAPFWDKVESRFSGYDAVKFRAAGVRVVPGAIARRGSYFGKDVVLMPSFTNIGAYVGEGTMIDTWATVGSCAQLGAHCHLSGGAAIGGVLEPLQASPAIIEDHCFIGARSEVVEGVIVGHHSVIGMGVFISQSTRIYNRATGEISYGYVPPYSVVVSGQLPAKDGTHSLYCAVIVKQVDEKTRAKTSINELLRGLAD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_XANOR
Sequence: MTQDYKATLHLPATEFPMRGDLPKREPAMLERWEREGFYAQLRANAAGRPLFVLHDGPPYANGQIHLGHAVNKILKDIIVKSKCLAGFDAPYIPGWDCHGLPIEIAIEKKYGKVGVKLDAAEFRQKCREYATEQIDLQRRDFKRLGVIGDWDNPYKTLDFRFEANEIRALAKVVDNGHLTRGVKPVHWCFDCGSALAEAEIEYADKVSPTVDIAYPARDPGAVAAAFGATLPGGVGVAVPIWTTTPWTLPASLAVSLGAELDYVLVEGPADRGQPRWLVIAEALAAKALARYGVDEVVVHGHAKGTALEQMLLNHPFYAEREIPLLLGDHVSAEDGTGAVHTAPGHGQEDYQVSKQYGLLERYGAAQINPVDGRGVYLPSTPPLGDTVLAGLHIWKANDVIIEALHGTGVLLAASKMEHSYPHCWRHKTPIAFRATPQWFISMEQANLRADALKAIESVHWYPSWGQARIAGMVDGRPDWTISRQRTWGVPIALFVHRETGEPHPRSTELLRQVADRVELGGVDVWYTLDAAELLGDEAADYDKITDILDVWFDSGVTHEAVLVDRGLPKPADLYLEGSDQHRGWFQSSLLSGVAMDKAAPYKQCLTHGFTVDEHGRKMSKSLGNGIEPQDIMKTLGADILRLWIASADYSNEMSLSQEILKRNADAYRRLRNTARFLLGNLHGFDPLQHLVALEDMVLLDRWIVHRAHELQEKIVAAYARYDFAEIVQALLNFCSVDLGSLYLDVTKDRLYTMAEDARGRRSAQSAMYHVAEAFVRWIAPVMSFTADELWGYLPGKHVGNVLFATWYGGLAPLPADAALTSADFDKLLALREQVSKVLEPMRANGAIGAALEAEITVAADVQTAARWQPLAEELRFLFISGDVTVTAASTDDIFVSAQPTTKAKCVRCWHHQSSVGSDPRHPELCSRCVSNIEGPGEERRWF
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_GEOUR
Sequence: MNIIVVGLSHKTATVEIREKVAFAPTQMEKPLHALVSLPDITEAVIVSTCNRVEIYATTRDIAGGVARLKRFLADYHNISLETLEPHLYSYHGEAATRHVFRVASSLDSMVVGEPQILGQIKTSYGYAAEYKSSGIILNRFLHKAFSVAKRVRTETKIASSAVSVAFAAVELAKKIFGDLSDKTVMLIGAGEMCELAAKHFINTGVRGVMVTNRTFERAVKLAEEFDGKAVNYEELFDHLHKADIVLSSTGAPHFIIGPKNVEEVIRRRKMKPMFFIDIAVPRDIDPKVNDVENIYLYTVDDLNGVVATNLEQRNKEAEKAEAIVEQEIGQFFKWLSSLEVTPTIVALRSKFDEIRRAELAKTLANWKELPPDAEKRLEALTSAIMNKLLHQPTSVLKRAEQGNRNDLYIDALRNLFELETTRPEVEELGELEE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: RLME_BORRA
Sequence: MYNVFDEYSQKAKNEGYLARSVYKLIEIDKKFSLFSSGNILDIGASPGSFSQYAYANLKNGVLVAVDLNDVNLNFTSNFYFIKGNIYLDEVYQKIKIFSPYSLIVSDAAPSTTGNRLVDTSNSFNLNIRIFELACESLMRGGNLLIKVFQGGEEEQIFYKLKSCFRVVKKVRPKAVRKNSFEIYFLAKDFAKL
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_LACH4
Sequence: MRTIAIDAMGGDNAPEAIVEAVLKAKAEMPDTKFLLFGDKEQLRKLIPSDQINDQLGVVATTEIIADEDEPVKAIRRKKDSSMVVAANFVKEGKADALLSLGNTGALLACGIFIIGRIKGIARPGLMPTLPVQNSDDGFNMVDVGANAKSKPEFLLQWAEMASYYAEKIRGIQNPRIMLLNNGSESDKGDDVHQAAYELLKDSDLNFQGNIEGNELLLGKADVVVTDGFTGNAVLKNIEGTSSFILHILKDSLLNGGVMTKLGALMVNGSLSSLKSKFDTAKYGGAILLGVNAPVVKTHGRSNESPIYFTLKQVDKMIKENLVQDFKDEFATK
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: COX2_BALMU
Sequence: MAYPFQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIITLMLTTKLTHTSTMDAQEVETVWTILPAIILILIALPSLRILYMMDEVNNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSDLKPGELRLLEVDNRVVLPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLFYGQCSEICGSNHSFMPIVLELVPLEFFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TSAD_STRPQ
Sequence: MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITTCFEDALQEAGISASDLSAVAVTYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETRDDAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNAKQKGDELILEDLCASFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCGDNAGMIALAAAIEYDKQHFANMSLNAKPSLAFDQFPDSFVIN
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 6PGL_ECO27
Sequence: MKQTVYIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRIAPDDGALTFAAESALPGSPTHISTDHLGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAGPRHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHITPDGRHLYACDRTASLITVFSVSEDGSVLSKEGFQPTETQPRGFNVDHSGKYLIAAGQKSHHISVYEIVGEQGLLHEKGRYAVGQGPMWVVVNAH
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: RGI1_CANDC
Sequence: MAGKKKSKSDSLPLDLDNIKPLDHLQPVPKTRSSSITSIESVDEPGTMKQVLLPPTIREFDELDQFESFVRDETWDNDFDYFHGKLHYYPPFVMKSCQNNLEKIKPTMNKNSKKFRRDLHHHIQKHLIKDLEKCCGYELNFGKGEIVETDNKVTWKFKDETDHGFSKEEEDLYDRHWRLELDVSCTNESAMVDVEYKSIPM
What is the function of this protein?
Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
What are the official names of this protein?
Respiratory growth induced protein 1.
What is the protein family that this protein belongs to?
Belongs to the RGI1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SSRP_STRPF
Sequence: MAKGEGHILAQNKKARHDYHIVETVEAGIVLTGTEIKSVRAARIQLKDGFAQIKNGEAWLVNVHIAPFEQGNIWNADPERTRKLLLKKREITHLANELKGTGMTLVPLKVYLKDGFAKVLIGLAKGKHDYDKRETIKRRDQERDIKKQMKHYNAR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: IF2_CHLAB
Sequence: MKIKNAQLTKAAGLDKLKQKLAQAGSSDTKSSSEKPTTKVPEKVAKEKVVKKKSVLDSSVPTMAEHVSTETSPRRIRAKNRSSFASEDSTIPSPVSVDTESTAFSPPVVEEVVSPLESAEPEIVEPTPASIVDEPETTIQEPPPPKKEAELVVKKEPPKNVVSIKSNFGPTGKHINHLLAKTFKAPKKEDKPAPKERTGTVQTKPQQSSEVPSDKQHSSNNRQSQPFYRRDTSKRPGSDFRDRSKKDDSPKAFTGRDRYGLNDSSDDDKWRKKRVQKTKKHYDEHSVQRPTHIKVPLPITIKDLAAEMKLKASELIQKMFIHGMTYVVNDVLDNETTVQFIGLEFGCTIDIDSSEQDKLCIESNTVKEEIQETDPSQLIIRPPIVAFMGHVDHGKTTLIDSLRKSNVAAVEAGAITQHMGAFCCSTPVGNITILDTPGHEAFSAMRARGAEVCDIVVLVVAGDEGIKEQTLEAVKHARAANITIVVAINKCDKPNFNADTVYRQLSEINLLPEAWGGTTVTINTSAKTGEGLSELLEMLALQAEVLELKANPEARARGIVIESELHKGLGAVATILVQNGTLHLGEALVFNDCYGKVKTMHNEHNQLMTSASPSVPALITGLSSMPKAGDPFVVVKNEKTAKEIVNARIAGQQKFALQKKRPNFDAMLQNKKILKLIIKADVQGSIEALSSSVLKIVSDKVSAEILSSSVGEISESDIRLAAASKAVIIGFHTGIESHAESLIKNLGVKVHLFNIIYHAVDAVKEMMTALLDPIAEERNLGSAEIKETFKSSQLGTIYGCLVSEGVMTRNQKVRVVRNNEVLWKGNLSSLKRIKEDVKEVKKGLECGILLEGYQNAQVGDILQCYEVIYHPQKL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_LATSS
Sequence: MSVKIRMKRMGSKKRPFYRIVVADSRSPRDGRFIQQVGYYNPLTEPVDLKLEEEVIMDWLQKGAQPSDTVRNLLSKQGIMQKYHEARFAKK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: NOP14_KLULA
Sequence: MGGSQLKNLKAALKANGLTGQTNVKKSSKKKGKSPREFDREERQKTIERIREQFNPFDVKTNRNKKVGVMRESAAKLAVGKPGITKQAGEDQRKMFYEAKKSSKNRSGGVLDKRFGEKDKNLTSEEIMLERFTKERQRQSSTKRSLFNLDDSDGGEDENVYGEKLTHYGKSLSLEDDFDEGDLGLQHSDSEDFRLKQAGKRNMADQYGDEGLGDDALQEPARKKTKAEVMQEVIAKSKFYKHERQKAQEKLVQDIEGLDDDFESIMSELRTLPKTKPSQTEISTSTDIAPDYDIKVKELVLEKRAAPADRTKTDEEIKKEYEDKQKELEQKRLDRMNGIFNIEDQKDAGVEDLGEEFWEDSDSEEGEYGEYIKAIPDSDDDVDFEKDNNDDNEYDATSNGRPSARVIPSVPCPQIHDDLLNFLKSYPIEEHPSLVKRIVKTYQPKLAEGNKEKLGKFTAVLLRHILFLAEEDYSVNVKEIASLQNELVSILKTLSEKFTIPLSEDCRNIISDIQTRFKESQFYGLSPSDLVFFSVVGMLFSTSDHYHLVITPCLLLIAEFLEQIRFNSLQKLIFGSILVRIAIQYQRISKRYIPELTYFLQTSLRSLIPSTKGETLENKEKQEDNLSIVGSDINWSKVAPSLELHSLFSEDLEKQESIKLSVLVNNLESIDWCITNIWKDLTAFPEIINPFKDILNVAAEVYPGTSKPKQLVEKIEKLLKFQERLPLTLQQHKPLAIPSNTPKFEENFNPDKKSYDPDKTRSELNKMKAQLKKERKFTMKEIRKDTRFEARQGIEEKKKEYADYHSKMARIVNQISTEEGAEKNKYEREKKLRNTKR
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.  Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
What are the official names of this protein?
Probable nucleolar complex protein 14.
What is the protein family that this protein belongs to?
Belongs to the NOP14 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PPK35_SCHPO
Sequence: MDLLGLKELDNNKLVSKAKENGVEFSDLFLLSSGYLRDRENASASVSSKNERMVLNEERQNCWTKRNDPKGLTYYQLLKPSEVEILSRPETRRKRMACQVFFLNYYISTIEYHKLRKERLEEFTACTSSLKQSKQKRLWKEHCGRERAFLRKKRTKIQCSHFDLLVKLGQGGYGSVWLAKKRNTHELLAMKMMKKSTLQQLNEVKHILNERDILTNTNSEWLVKLYYAFQDKEKVYLAMEYVPGGDFRTFLTTKGLLHENQTRFYLAEMVAAISAVHKLGYMHRDLKPENFLIDQKGHIKLSDFGLSTAIVTSNQVNRLQHALVSAVNPQRPYLTQKQRRNIYKALLEKNENKVNSVVGSPEYMAPEVVYGKKYDRTVDYWSLGCICYECLVGYPPFSGSTLQETWTNLYYWREMLQRPSKNENGIYDKKARSVSDEAWSFITKCLTEPTSRFQSTIEIQKHPFFKRLHWNGLRKRAVPPFVPRLENQLDTSYFDDFNDEQVLDAYKDVYEKQRKAEQKAKSNGVMNGNQRQFLGFTFKYRPNARKPLVGRHREKRQLRKEKPEKKNNSTKQKDLITVSHNKGTTAIEDLDEDKRSKTKGHKTKSSRVHRLLERKGKDLYEFLL
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Serine/threonine-protein kinase ppk35, Meiotically up-regulated gene 27 protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: PTPRN_MOUSE
Sequence: MRRPRRPGGSGGSGGSGGLRLLVCLLLLSGRPGGCSAISAHGCLFDRRLCSHLEVCIQDGLFGQCQAGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQHVISQEMERIPRLRPPEPHPRDRSGLVPRKPGPAGELLTQGNPTGSSPAAQGFPRPAGGRSWGGSPLSSLQAELLPPLLEHLLMPPQPPHPALTYEPALLQPYLFHQFGSRDGSRGSESSSGVVGVGHLSKAEGPALFSRSASKAILGTHSGHSFGDLTGPSPAQLFQDSGLLYMAQELPVPGRARAPRLPENGGNRAEDSSEGHEEEVLGGRGEKSPPQAAQPELSLQRLTAVLAGYGVELRQLTPEQFSTLLTLLQLLPKGTGRNLEGAVNVGGADVKKTIQQMQRGDPAEALPPTPSLPGYLTASPASSEVQQVLSPGFPEPPHTPSPLGSSSVLLEKKSPLGQSQPTVVGRPSARPSAEEYGYIVTDQKPLSLVAGVRLLEILAEHVHMSSGSFINISVVGPAVTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEAAEVLPRQAHGISPMRSVLLTLVALAGVAGLLVALAVALCMRHHSRQRDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGQPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCAAAQDESNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGSSLYHVYEVNLVSEHIWCEDFLVRSFYLKNLQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ
What is the function of this protein?
ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (By similarity).  Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:18178618).  ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (By similarity).
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, PTP IA-2.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, axon. Synapse. Cell membrane; Single-pass type I membrane protein. Endosome. Note=Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin- containing secretory granules. Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes. SUBCELLULAR LOCATION: [ICA512-transmembrane fragment]: Cytoplasmic vesicle, secretory vesicle membrane. SUBCELLULAR LOCATION: [ICA512-cleaved cytosolic fragment]: Nucleus.
Protein: RL11_OCEIH
Sequence: MAKKVIKLVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTQDQAGMIIPVEITVFEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNKNKVASVKRDQVKEIAETKMPDLNAADVDAAMRMVEGTARSMGITIED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: UB4AB_ONCMY
Sequence: MILTIKPLKGKECNVQVTEDEKVSMVKELVSERLNIPANQQRLLYKGKALADEYRLSDYSIGPEAKLNLVVRPAGERSGMASSSSAVSGVWQTLSTVLAKHFSPADAAKVHEQLIKDYERSLRQLSLDDIERLAGRLLHPDSEGMDTSYMD
What is the function of this protein?
Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane.  TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region (By similarity).
What are the official names of this protein?
Ubiquitin-like protein 4A-B.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: COBS_BRUC2
Sequence: MQRNGLIGDTIRSLGFLSRLPLPQGWFDNTDDSLPRNARAFPLAGGILGLLAGVALLIANAISLPPLAAALIAIGALAAMTGALHEDGLGDTADGFFGASTPDRRLDIMKDSRIGTFAALTLVIWTGVKASLLMAIIARAGAGYALLALIGTEAASRAGMLAFWHALPSARPGGLADSMGQPQWETVVCGCGLGLALLAIGFLPSGGMVALINALVLMTVVLFGFARLCMAKIGGQTGDTLGAAQQIGSLAALIGLVMAL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.