PharMolix/UniProtQA huggingface dataset:
Protein: GLII_ASPFU
Sequence: MPSETITPLLAHRARTNIQWFTHKHMRQVSRLNAKQHRVNMMTAENWSIRDELVDQYKTLFAQHLSPRHLSYADGMGGDAELLQAAADFFNRVFAAHSRVQPAHLVVGAGCSSLLENLLYDICEPGEGVLIETPFWGGFETSFVLRSNVTAVHVRPPCHGNGSADLDRLVSAYIEAYERALRQAPCRIKAILVCNPHNPCGHIYPPRVIQALLQFAQRHDLFYISDEIYALSTLDEQTAFTSVLSIDVAALGVDLARVFTLYSISKDLGSSGLRLGFGITQAHPDLRLSLAISNHSRVSTFTSLVITALLHDPEAATAILHQNRAALQRSAKLISDFLAFHQIPFVPPAAGVYVWARLGWRSSSRPGDEPSWDEEARLNDRFEAAGVSVGAGQGYCASEPGWFRITFAIPREELVAGLRRIEQVVGMEGQKWTAI
What is the function of this protein?
Probable aminotransferase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide (PubMed:15979823, PubMed:21612254).  The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP (PubMed:17154540, PubMed:21612254).  GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp (PubMed:23434416).  The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain (PubMed:24039048, PubMed:23434416).  The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin (PubMed:21513890, PubMed:21749092).  This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties (PubMed:22903976, PubMed:24039048).  Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure (PubMed:20548963, PubMed:22936680, PubMed:24039048, PubMed:25062268).  GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides (PubMed:25062268).  Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA (PubMed:26150413).  Gliotoxin contributes to pathogenesis during invasive aspergillosis (PubMed:17601876, PubMed:18199036).  In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species (PubMed:17601876).
What are the official names of this protein?
Probable aminotransferase gliI, Gliotoxin biosynthesis protein I.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: DAPB_BACSU
Sequence: MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQKLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTTGFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQKLDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQEVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_STAAS
Sequence: MLQHKILGLDVGSRTVGIAISDIMGWTAQGLDTLRINEENNELGIDQLVDIIKKHNVGTVVIGLPKNMNNSIGFRGEASLTYKEKLLEAYPSIEIVMWDERLSTMAAERSLLEADVSRQKRKQVIDKMAAVFILQGYLDSLH
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_PROMP
Sequence: MSIHPKLNNKQRRIGLTGGIASGKSTIAKYIKEYIDIPILDADQYSKDLIKPKSNCYKKVVAYFGPQIVDQHSSENEINRALLKKIIFENSIHRKWIQNLLHPLIKEKMIEKCNQFDKNKILLLVIPLLFEAKFGDICTEIWLVKCPKEVQKKRLMKRNIISENEAQKIINLQLNFEDKSKFADVILDNSDNKQLWKNTIKKLV
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APT_RUMCH
Sequence: MDLKDKLRHVMDFPKEGIDFIDITTVLQDPEAFRECMESFKTLAEKMGDFDLIVGSESRGFIFGAPLAYRMEKGFVPVRKKGKLPYKTVREEYDLEYGKDELEIHSDAIAPGEKVLIVDDLLATGGTTEANIKLVEKLGGEVTGIVYFIELMSLKGRDKLKGYNVDSIVKF
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_BRUSU
Sequence: MSDLEQLERQILEDIAAAVDEQGIEAVRVAALGKKGTVSEKLKTLGGMSPEERQMQGPAINGLKNRVTEALSERRTELRKAAVAARLEREKVDVTLPVRESAASRGRIHPISQVIDEITAIFADMGFSIAEGPDIETDYYNFTALNFPEGHPAREMHDTFFFNPDEKGERKLLRTHTSPVQVHTMEKFAAMRDKEGRDEPIRIVIPGKTYRMDSDATHSPMFHQVEGLVVDKSANVANMKWVLEEFCKAFFEVPSVKMRMRPSFFPFTEPSVEVDIQCDRSGPHVKFGEGNDWLEILGCGMVHPNVLRMSGYDPEVYQGFAWGMGIDRIAMLKYGMPDLRAFFDADVRWIEHYGFRPLDIPTLFGGLSA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARI1_HUMAN
Sequence: MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDGLLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED
What is the function of this protein?
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686).  Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346).  The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346).  E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346).  Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349).  According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349).  According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119).  Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).  In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology (PubMed:29689197).
What are the official names of this protein?
E3 ubiquitin-protein ligase ARIH1, H7-AP2, HHARI, Monocyte protein 6, MOP-6, Protein ariadne-1 homolog, ARI-1, UbcH7-binding protein, UbcM4-interacting protein, Ubiquitin-conjugating enzyme E2-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the RBR family. Ariadne subfamily.
Protein: G1PDH_ARCFU
Sequence: MRFKTVDLPYHVYIGENVISKLPKVLRSLDANYFLLLTDEVVKNLVVVNLKETLKDFEYDMMLVESAKMEEARKIVLRGGFADYDAVVGVGGGKVLDVSKVVSSELNASMISVPTTASHDGIASPVASFKENGKPISISTNPPSAVIADLNIIKNCPIRLLRSGYGDLVSNISSVKDWQLARDLVGEDYNEVAASIAVMPAQLMVSKADELDLTLPPHLLMLLRGLIMSGVAIAFVGSSRPASGAEHKFSHALDYLGYGNGTHGEQVALGTIIMEYLHEKYYGRGDWEQIKMSLEKVHAPTTAKEIGLTREQVIEALMLATKLRKKRFTILEAVKPTKEEFELVVEKTGVA
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_ROSDO
Sequence: MTKEQWGQLQQRLLKTVGQNNYKNWIEPIEFGSTQDGVATFEVPTNFLGNYVSQNFADLILHEVRQEDPAVRRLRFAVPSHVNATTKPARPAQATAPRAPAEKTPRSTLSTAPLDARFTFDNFIVGKPNELAHAAAKRVAEGGPVTFNPLFLYGGVGLGKTHLMHAIAHELRLRRPEMNVLYLSAEQFMYRFVQALRDRKMMDFKEIFRSVDVLMVDDVQFIAGKGSTQEEFFHTFNALVDQNKQIIISGDRAPGEIKDMEERVKSRLQCGLVVDLHPTDYELRLGILQSKVEQQRKNYPGLDISDGVLEFLAHRISTNVRVLEGALTRLCAFASLVGREIDMELTQDCLSDVLRASERKITVEEIQRKVSDHYNIRLSDMIGPKRLRSYARPRQVAMYLSKKMTSRSLPEIGRRFGGRDHTTVMHGVKRIEELKIQDGQIAEDLELLRRALEE
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_HAEIN
Sequence: MFYTETYDVIVIGGGHAGTEAALAPARMGFKTLLLTHNVDTLGQMSCNPAIGGIGKGHLVKEVDAMGGLMAHAADKAGIQFRTLNSSKGPAVRATRAQSDRVLYRQAVRTALENQPNLDIFQQEATDILIEQDRVTGVSTKMGLTFRAKSVILTAGTFLAGKIHIGLENYEGGRAGDSASVNLSHRLRDLGLRVDRLKTGTPPRIDARTINFDILAKQHGDEVLPVFSFMGSVDDHPQQIPCYITHTNEQTHEVIRNNLDRSPMYTGVIEGIGPRYCPSIEDKVMRFADRNSHQIYLEPEGLTSNEVYPNGISTSLPFDVQMGIVNSMKGLENARIVKPGYAIEYDYFDPRDLKPTLETKSISGLFFAGQINGTTGYEEAAAQGLLAGINAGLYVQEKDAWYPRRDQSYTGVLVDDLCTLGTKEPYRVFTSRAEYRLLLREDNADIRLTPIAHELGLIDEARWARFNQKMENIEQERQRLRSIWLHPRSEYLEEANKVLGSPLVREASGEDLLRRPEMTYDILTSLTPYKPAMEDKEAVEQVEIAIKYQGYIEHQQEEIEKQKRHENTAIPANFDYSKVSGLSNEVRAKLEQHRPVSIGQASRISGITPAAISIILVNLKKQGMLKRGE
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_RICRS
Sequence: MRNIIYFILSLLFSVTSYALETINIEHGRADPTPIAVNKFYADNSAADVLGHDMVKVISNDLKLSGLFRPISAASFIEEKTGIEYKPLFAAWRQINASLLVNGEVKKLESGKFQISFILWDTLLEKQLVGEILEVPKNLWRRAAHKIADKIYEKITGDAGYFDTKIVYVSESSSLPKIKRIALMDYDGANNKYLTNGKSLVLTPRFARSADKIFYVSYATKRRVLVYEKDLKTGKESVVGDFPGISFAPRFSPDGRKAVMSIAKNGSTHIYEIDLATKRLHKLTDGFGINTSPSYSPDGTKIVYNSDRNGVPQLYIMNSDGSDVQRISFGGGSYAAPSWSPRGDYIAFTKITKGDGGKTFNIGIMKACPQDNKNSERIITSGYLVESPCWSPNGRVIMFAKGWPSSSKAPGKNKIFAIDLTGHNEREIMTPADASDPEWSGVLN
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TM9S1_RAT
Sequence: MTVLGHPRSWSCHCLPVLILLLGIGHGPRVEGVTHYKPGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRSDELLGLTHTYSVRWSETSVEHRSDRRRADDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETSSGGSSDDFDQGDNGWKIIHTDVFRFPPCRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPVTTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPCAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD
What is the function of this protein?
Plays an essential role in autophagy.
What are the official names of this protein?
Transmembrane 9 superfamily member 1.
What is the protein family that this protein belongs to?
Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.
Protein: KAX3H_BUTPA
Sequence: GVPINVKCSGSRDCLEPCKKAGMRFGKCINRKCHCTPK
What is the function of this protein?
Completely inhibits the (125)I-kaliotoxin binding on rat brain synaptosomes with high-affinity (IC(50)=0. 1 nM).  Is a potent Kv1. 3/KCNA3 ligand.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 3.17, Toxin BoPKTX.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 03 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ALL4_CYDPO
Sequence: ARPYSFGL
What are the official names of this protein?
Cydiastatin-4.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNMA_STRTD
Sequence: MTDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADQIDIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQVVRDEDGIVHMLRGADNNKDQTYFLSQLSQEQLQKAMFPLGHLQKSEVREIAERAGLATAKKKDSTGICFIGEKNFKEFLSQYLPAQKGRMMTVDGRDMGEHNGLMYYTIGQRGGMGIGGQKGGDNAPWFVVGKDLSKNILYVGQGFHHESLMSTSLDASTIHFTRDMPEEFEMECTAKFRYRQPDSKVTVKVKGDKSEVIFAEPQRAITPGQAVVFYDGQECLGGGIIDQAYKDGKVCQYI
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPDA_KLEP3
Sequence: MNALNAAMTVIGAGSYGTALAITLARNGHHVVLWGHDPKHIATLQHDRCNAAFLPDVPFPDTLHLESDLATALAASRDILIVVPSHVFGQVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDDIPLAVISGPTFAKELAAGLPTAISLAATDPQFAEDLQHLLHCGKSFRVYINPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLVEMSRLGAALGADPETFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQDKIGQVVEGYRNTKEVRVLAQRLGVEMPITEEIYQVLYCGKIAREAALTLLGRARKDERSSN
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUCL3_HUMAN
Sequence: MAQPVHSLCSAFGLQCCLLFLLASWGAGATTFQEYQKTGELSTSDHIFPLTPGLVYSIPFDHIVLHSGQRPPELPKSTEIHEQKRHCNTTRHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENKKTICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTENPEKTAAVTKTIKPSVKVTGDKSLTTTSSHLNKTEVTHQVPTGSFTLITSRTKLSSITSEATGNESHPYLNKDGSQKGIHAGQMGENDSFPAWAIVIVVLVAVILLLVFLGLIFLVSYMMRTRRTLTQNTQYNDAEDEGGPNSYPVYLMEQQNLGMGQIPSPR
What is the function of this protein?
May modulate NF-kappaB signaling and play a role in cell growth.
What are the official names of this protein?
Mucin-like protein 3, Diffuse panbronchiolitis critical region protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Protein: PNP_PECAS
Sequence: MLNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGAKNAKPGQSFFPLTVNYQERTYAAGRFPGGFFRREGRPSEGETLTSRLIDRPIRPLFPEGFLNEVQVIATVVSVNPQVSPDIVAMIGASAALSLSGIPFSGPIGVARVGYLNDQYVLNPTTDELKESRLDLVVAGTQGAVLMVESEAELLSEDQMLGAVVFGHEQQQIVIENINSLVAEAGKPKWEWHAPAVNVSLEQRVQALSEARLGDAYRITEKQERYAQVNVIKTDVVAALQAEDETLNAGEIQEILGNIEKNVVRGRVLAGEPRIDGREKDMIRGLDVRTGVLPRTHGSALFTRGETQALVTATLGTERDAQNIDELTGERTDRFLLHYNFPPYCVGETGMVGSPKRREIGHGRLAKRGVLAVMPKANEFPYTVRVVSEITESNGSSSMASVCGASLALMDAGVPIKSAVAGIAMGLVKEGDNFVVLSDILGDEDHLGDMDFKVAGSREGITALQMDIKIEGITREIMQVALNQAKGARLHILGVMEQAISTPRGDISEFAPRIHTIKISTDKIKDVIGKGGSVIRALTEETGTTIEIEDDGTVRIASTDGEKAKHAIRRIEEITAEIEVGRVYQGKVTRIVDFGAFVAIGGGKEGLVHISQIADKRVEKVTDYLQMGQEVPVKVLEVDRQGRVRLSIKEANPQTQEAAAPSSEE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFQ_CLOPE
Sequence: MNKSINNLQDIFLNNARKERIPVTIFLVNGVQLKGIVKGFDSFTVVLDSDGKQQLVYKHAISTVSPAKPILFNNAQVFDN
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: BIOF_ECOSM
Sequence: MSWQEKINAALDARRAADALRRRYPVAQGAGRWLVADDRHYLNFSSNDYLGLSHHPQIIRAWKLSAEQFGVGSGGSGHVSGYSVAHQALEEELAEWLGYSRALLFISGFAANQAVITAMMAKEDRIVADRLSHASLLEAASLSPSPLRRFAHNDVTHLARLLASPCPGQQLVVTEGVFSMDGDSAPLEEIQQVTQQHDGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVVTFGKGFGVSGAAVLCSNTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSWSAIQPLIVGDNSRALQLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHDNG
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: FTSH_MESM1
Sequence: MSELDNKKDKSKDSNKKPKKPGAFSIGNIIIFVIVALLLIWVVFAFLPNNPGTNKSFDGFLKDLQDAARLGDDTIFFRNISFDVVLSRFNVTFVNGATTSSYFVNYPSSVAFQNLQIPGTTFTGLELATLAIANTSASGIGTLNFSGLVTPTNQALAILLSLIPTFLFVGIIFFVYKMQSKANGGMGGFNPGKNQAERIYTKIKFSDIAGNEEVKEEVAELVDYLKNPKKYSASGARIPRGILLGGPPGTGKTLLAKATAGEANVPFYFISGSNFVELFVGVGAKRVRELFKEARKSSPAIIFIDELDAVGRSRGAGIGGGNDEREQTLNQLLVEMDGMTENSGLLVMAATNRTDVLDPALLRPGRFDRTVTVGLPNVKDREAILKLHAKGKRISSEVSFQQLAKRTPGYSGAQLENVINEASLLSVREDTKIITLEQFDEAIDRVMSGPAKKSRVITKEELTAVAYHEAGHAVVGTQLRKGVKVQKITIIPRGSAGGYNLMIPEEEKYNSSKSELIAMITSFMGGRAAEQIIYGEKEVSTGARDDIKKATSIARKMVTEWGMSDLGPIMYEEDTSNPFLGRDYTKNQLFSDHIAREIDTEVRKIILTAEQKAIEVIQENREMLELIKEALLENETIVDEEIQYIAKNLKLPSMRTKAKSENVNQIRNVDELVKEVKDQTLIIKDKNDKKIKDSENNIKTDESLDIK
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
Protein: 5HT4R_MOUSE
Sequence: MDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPSDT
What is the function of this protein?
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.  The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Protein: SENJU_DROME
Sequence: MSTNWRELFPTKLTFVIFLLYMSLFIGQGIFVTASQESNNSYGYNTVTVVLLTEVFKLIVSTCLYCRDNNLRSLVRDVQKDRNVLGLYMVPAFLYCLYNNLAFVNLATFDPTTYYLLLQLRVVVTGILFQIIFKKYLSQRQWISLILLTLGCMMKQVDFGSFYSDANDDSESAAIQQQLQSHNKTTSAETHAHGKNMSGFDFSLSAVFILAQTICSCLAGVYNEYLLKDKGADVNIFVQNVFMYLDSIVCNAVILLLRGELLDAFSPQNLGSIMRFSVLIIIVNNAAIGIVTSFFLKYMNSILKTFASALELLFTAVLCYFLFSIPIYMNTALAIAVVSYAIYLYTQSPVVNLGKVRPLSNLSDATTKSTDKRKLIDEEAAESDLDMV
What is the function of this protein?
UDP-galactose transporter involved in the synthesis of galactose-containing glycans.  Plays a role in quiescence of the innate immune response, possibly by regulating glycosylation of the Toll pathway ligand spz.
What are the official names of this protein?
UDP-galactose transporter senju.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: FTSH_CAPAN
Sequence: KYFNFHSKRKCIITQSTLNKKPNSDNFKNAQSKAALAALLFSSITPHAIALDDAAPIASPPQVMEVEAPNPNTSNPLPFSQNLVLNAPKTQASPVSDLPESTQWRYSEFLNAVKKGKVERVRFSKDGSALQLTAVDGRRANVIVPNDPDLIDILAMNGVDISVSEGEGGNGLFSVIGNLLFPFIAFAGLFFLFRRSQGGPGGPGGLGGPMDFGRSKSKFQEVPETGVTFADVAGADQAKLELQEVVDFLKNPDKYTALGAKIPKGCLLVGPPGTGKTLLARAVAGEAGVPFFSCAASEFVELFVGVGASRVRHLFENAKSKAPCIVFIDEIDAVGRQRGAGLGGGNDEREQTINQLLTEMDGFSGNSGVIVLAATNRPDVLDSALLRPGKFDRQVTVDRPDVAGRVRILQVHSRGKALAKDVDFDKIARRTPGFTGADLQNLMNEAAILAARRDLKEISKDEISDALERIIAGPEKKNAVVSDEKKKLVAYHEAGHALVGALMPEYDPVAKISIIPRGQAGGLTFFAPSEERLESGLYSRSYLENQMAVALGGRVAEEVIFGEDNVTTGASNDFMQVSRVARQMVERLGFSKKIGQVAIGGGGGNPFLGQQMSTQKDYSMATADVVDSEVRELVEKAYERAKQIITTHIDILHKLAQLLIEK
What is the function of this protein?
Seems to act as an ATP-dependent zinc metallopeptidase.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FTSH, chloroplastic.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.