PharMolix/UniProtQA huggingface dataset:
Protein: AROC_SALSV
Sequence: MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFDGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLEIKDWRQVELNPFFCPDADKLDALDELMRALKKEGDSIGAKVTVMASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGEGFNVVALRGSQNRDEITAQGFQSNHAGGILGGISSGQHIVAHMALKPTSSITVPGRTINRMGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRHRAQNADVKTEIPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ZNUC_PSEF5
Sequence: MSNALIRLEQVGVTFAGQNVLENIQLSVEPGQIVTLIGPNGAGKTTLVRAVLGLLKPDTGSVWRKPKLRVGYMPQKLHVDPTLPLSVLRFLRLVPGVDRTRALAALKEVGAEQVIDSPVQSISGGEMQRVLLARALLREPELLVLDEPVQGVDVAGQAELYSLITRLRDRHGCGVLMVSHDLHLVMSTTDQVVCLNRHVCCSGHPEQVSGDPAFVELFGKNAPSLAIYHHHHDHAHDLHGSVVTQPASGHAHVHGENCKHG
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MADCA_MOUSE
Sequence: MESILALLLALALVPYQLSRGQSFQVNPPESEVAVAMGTSLQITCSMSCDEGVARVHWRGLDTSLGSVQTLPGSSILSVRGMLSDTGTPVCVGSCGSRSFQHSVKILVYAFPDQLVVSPEFLVPGQDQVVSCTAHNIWPADPNSLSFALLLGEQRLEGAQALEPEQEEEIQEAEGTPLFRMTQRWRLPSLGTPAPPALHCQVTMQLPKLVLTHRKEIPVLQSQTSPKPPNTTSAEPYILTSSSTAEAVSTGLNITTLPSAPPYPKLSPRTLSSEGPCRPKIHQDLEAGWELLCEASCGPGVTVRWTLAPGDLATYHKREAGAQAWLSVLPPGPMVEGWFQCRQDPGGEVTNLYVPGQVTPNSSSTVVLWIGSLVLGLLALVFLAYRLWKCYRPGPRPDTSSCTHL
What is the function of this protein?
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria.  It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.  Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7.  Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
What are the official names of this protein?
Mucosal addressin cell adhesion molecule 1, MAdCAM-1, mMAdCAM-1.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PSAI_PEA
Sequence: MINLPSLFVPLVGLLFPAVAMASLFLHVEKRLLFSTKKIN
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: YIHI_ECO24
Sequence: MKPSSSNSRSKGHAKARRKTREELDQEARDRKRQKKRRGHAPGSRAAGGNTTSGSKGQNAPKDPRIGSKTPIPLGVTEKVTKQHKPKSEKPMLSPQAELELLETDERLDALLERLEAGETLSAEEQSWVDAKLDRIDELMQKLGLSYDDDEEEEEDEKQEDMMRLLRGN
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: UPK2_PIG
Sequence: MASPLPVRTLPLILILLAVLAPGASDFNISSLSGPLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVVKSSFMVPPCRGRRELVSVVDSGSGFTVTRLSAYQVTNLVPGTKYYISYLVTKGASTESSREIPMSTLPRKNMEGIGLGMARTGGMVVITVLLSVAMFLLVVGFITALALGARK
What is the function of this protein?
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells.  May play an important role in regulating the assembly of the AUM (By similarity).
What are the official names of this protein?
Uroplakin-2, UP2, Uroplakin II, UPII.
What is the protein family that this protein belongs to?
Belongs to the uroplakin-2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER).
Protein: NFI_XANC5
Sequence: MQTNDPVFAGWDGSVIQARQLQQQLARRVVLDDAVSATPQLLAGFDVGFEDDGQTTRAAAVLLDAQTLLPLETHVARVPTSMPYVPGLLSFRELPALLRALALLSRTPDLVFIDGQGIAHPRRLGIAAHFGVVTGLPCIGIAKQRLAGSFAEPGPERGDHTPILLGGAQIGWALRSKPRCNPLIVSPGHCVSMQGALDWTLRTLRAYRLPEPTRLADRLASRRGEVTVPAACSGQLL
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAOE_SCHPO
Sequence: MKQDVRIAIDRGGTFTDVYYKISGWREQEGIFKLLSVNPKLYDDAPTEGIRRVLCYASGEEIPRKVPLDLTRVSSIRMGTTVATNALLERKGEKTAFIITEGFRNLVEIGNQARPDLFDLTVSRPSPLYQRVIEAKERVVLENQFSKTAGIVQGITGEFLRVEKKLDEEALYQDLKELYNEGFRSISVSLMHSYTYPLHEEVVEKIAKRIGFTDISLSSKLTPMVKIVPRAVSAIIDAYLSSTLRYYLDSFKKNFYNVKPNTIQFMKSDGGLVDIDNFTAISAIMSGPAAGTVGFAKTSSLHADDKTPAIGFDMGGTSTDVSRYDGKFEHIYEANIFGLYIQSPQLDIQTVAAGGGSRLFWRNQLFSVGPESAGAFPGPACYLNGGPLTVTDANVLLGRIIPDFFPKIFGPKENESMNKDIVIEKFSELRDIINIDIEKEKTIEEIAMGFIQVANETMCRPIRKLTESRGLDLSAHHLAVFGGAGGQHACAIASLLNIEKIIIHKYSSVLSAYGLALAHVTHEEQMPCLSVLDEDNLPLIQSKFDVLDKKAVSFLENEGYLESQISTELFANLRYEGNDTTMMIAKPKDSWDFKTLFEESYKNQFGFSLIDRKIMVEDIRIRAIARASNQSEVDTVFASETENENTVFIRDNKPTMYTPVYFAEVGKVNCHVYQLSSLPVHSLITGPAVIVDTTQTLLIEPSFTAKIFARHVLLEKTKSTLVVKKNVDLDPITMTIFANRFMSISEQMGQVLQKTAVSVNVKERLDYSCALFSPDGGLVANAPHVPAMLGSMQTAVKWQHNYWKGKLVPGDVLLSNHPIAGGVHLPDLTVVTPVFDNNKDIIFYCAARGHMVDVGGITPGSMPSNSKAIYEEGAAIKTFKVVKAGTFDEKGLTQLLFDEPAKYPDCSGSRTLRDNISDVKAMLSACHRGRSMVEKLVVEYGLDIVQRSMYGIQAAAEKAVRDVLKAFSVQNSQKPLKAIDYMDDGTPLQLEVKIDPETGDAVFDFEGTGPEVYGNWNAPIAITYSSVIYCLRSIINQDIPLNEGCLKPIEIRIPPSCFLNPSETAAVVGGNVLTSQRITDVILKAFSICAASQGCMNNLTFGYDGENGEEGFAMYETIAGGAGAGPTWNGTSGVHTHMTNTRITDPEVVERRAPVILRRFCLRENSGGKGEYHGGDGVIRHFEFRRSMHCSILSERRSRAPYGMNGGEDGAMGVNTWIDCSNPDFPRYVNLGGKNHVLMGKGDHIVIETPGGGGYGAVSI
What are the official names of this protein?
Uncharacterized protein C11D3.14c.
What is the protein family that this protein belongs to?
Belongs to the oxoprolinase family.
Protein: HTRA2_DROGR
Sequence: MALRSITKLETFLKRYSAPTLYYCLHRSTQSSTCNSTNTDNGSHNTNYNSSNNNNNNNDNKRFSWRSAIRFLVPFSLGALASSVVAGDRELMPTISAKTLTNNRRDFNFIADVVASCADSVVYIEIKDTRHFDYFSGQPITASNGSGFVIEQNGLILTNAHVVINKPNTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVTNLSVMKLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKLFLERAAARRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRTQNMPETLSHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADGKKDLDMVILRGVKQMRVTITPEDP
What is the function of this protein?
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein.  Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism.  Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
What are the official names of this protein?
Serine protease HTRA2, mitochondrial, High temperature requirement protein A2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment. The extramitochondrial protein does not diffuse throughout the cytosol but stays near the mitochondria.
Protein: GHRA_ECO8A
Sequence: MDIIFYHPTFDTQWWIEALRKAIPQARVRAWKSGDNDSADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLNPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHREDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGERVCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_KLEP7
Sequence: MTRLTLALDVMGGDFGPSVTVPAALQALNSNSQLTLLLVGDPDAITPLLAKADFEQRSRLQIIPAQSVIASDARPAQAIRSSRGSSMRVALELVKEGRAQACVSAGNTGALMGLAKLLLKPIEGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLVQFAVMGAVLAEEVVGIANPRVALLNIGEEEMKGLGSIRDAAAVLKTLPSLNYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKRSWWLLLLKRWLQKSLARRFSHLNPDQYNGACLLGLRGSVIKSHGAANQRAFSVAIEQAVQAVQRQIPQRIAARLESLYPAGFELPESDSDVNARQQSGTNGHD
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RNC_LATSS
Sequence: MDAALVSELRARYGIEFNNLALLDEAFTHSSYVNEHRELGLRDNERLEFLGDAVMEITVSEYLYKKYPDWPEGKLTRLRAAIVCTKSFSSFSKEAHFDRYIRLGKGEEKNGARARATLLEDLFEAFNGALFLDQGRDAVVDFVSQVIFPKIEAGEFSDQTDYKTNLQEFLQQDGEIEIDYQLLAEVGPSHDRQFEVDVLVGDRVLGSGVGRNKKAAEQAAAKKALEQLKA
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOQE_BACSU
Sequence: MENNVLYGVYSTRSRKFCFGIEEPSKTKARKELFNRIGTDAYKWRFEIRKIKRK
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YoqE.
Protein: PUR7_ACICJ
Sequence: MARRRQLYEGKAKILFEGPEPGTLVQYFKDDATAFNAQKKGVITGKGVLNNRISEFLMQRLGEIGIPTHFVRRLNMREQLVREVEIIPIEVVIRNVAAGSMSTRLGIPEGTRLPRSIIEYYYKNDALNDPMVSEDHITAFGWASTQDMDDIVHLSLRINDFLTGLFLGVGIVLVDFKIEFGRLWENDDMRIVLADEISPDNCRLWDAKTNEKMDKDRFRRDLGRVEEAYQEVAKRLGILPEAGTRDMKGPETMQ
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: LSHR_CALJA
Sequence: MKQPLLALQLLKLLLLLLLPLPPLPRALREARCCPEPCNCTPDGALRCPGPGAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQSDSLERIEANAFDNLLNLSEILIQNTKNLIHIEPGAFTNLPRLKYLSICNTGIRKFPDVTKIFSSETNFILEICDNLHITTIPGNAFQGMNNESITLKLYGNGFEEVQSHAFNGTTVISLVLKENVHLERIHNGAFRGATGPSILDISSTKLQALPSHGLESIQTLIATSSYSLKKLPSREKFANLLDATLTYPSHCCAFRNVPTKDYPAIFAESGQSGWDYDYGFHLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCNTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQIYILTILILNVVAFIIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKMPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFRRDFFLLLGKFGCCKHRAELYRRKDFSAYTSNYKNGFTGSSKPSQSTLKLPALHCQGTALLDKTCYKEY
What is the function of this protein?
Receptor for lutropin-choriogonadotropic hormone.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
What are the official names of this protein?
Lutropin-choriogonadotropic hormone receptor, LH/CG-R, Luteinizing hormone receptor, LSH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NFUA_KLEPN
Sequence: MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEDTDTALKFEQLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKARTPKCAK
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins (By similarity).
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: YCGL_ECODH
Sequence: MPKPGILKSKSMFCVIYRSSKRDQTYLYVEKKDDFSRVPEELMKGFGQPQLAMILPLDGRKKLVNADIEKVKQALTEQGYYLQLPPPPEDLLKQHLSVMGQKTDDTNK
What are the official names of this protein?
Protein YcgL.
Protein: EFTU2_RHIEC
Sequence: MAKSKFERNKPHVNIGTIGHVDHGKTSLTAAITKYFGEFKAYDQIDAAPEEKARGITISTAHVEYETPARHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLARQVGVPAIVVFLNKVDQVDDAELLELVELEVRELLSSYDFPGDDIPVVKGSALAALEDSDKKIGEDAIRELMAAVDSYIPTPERPVDQPFLMPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIRPTSKTTVTGVEMFRKLLDQGQAGDNIGALIRGVNRDGVERGQILCKPGSVKPHKKFKAEAYILTKEEGGRHTPFFTNYRPQFYFRTTDVTGIVTLPEGTEMVMPGDNVTVDVELIVPIAMEEKLRFAIREGGRTVGAGIVAIESLE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNA_ECOLC
Sequence: MKTVVFAYHDMGCLGIEALLAAGYEISAIFTHTDNPGEKAFYGSVARLAAERGIPVYAPDNVNHPLWVERIAQLSPDVIFSFYYRHLIYDEILQLAPAGAFNLHGSLLPKYRGRAPLNWVLVNGETETGVTLHRMVKRADAGAIVAQLRIAIAPDDIAITLHHKLCHAARQLLEQTLPAIKHGNILEIAQRENEATCFGRRTPDDSFLEWHKPASVLHNMVRAVADPWPGAFSYVGNQKFTVWSSRVHPHASKAQPGSVISVAPLLIACGDGALEIVTGQAGDGITMQGSQLAQTLGLVQGSRLNSQPACTARRRTRVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIDGGKQKRCFTDIRDGIEALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHHFPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNAHRCLDWEPKIDMQETIDETLDFFLRTVDLTDKPS
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: RPOA_STRP8
Sequence: MIEFEKPIITKIDENKDYGRFVIEPLERGYGTTLGNSLRRVLLSSLPGAAVTSIKIDGVLHEFDTIPGVREDVMQIILNVKGLAVKSYVEDEKIIELEVEGPAEVTAGDILTDSDIELVNPDHYLFTIAEGHSLRATMTVAKKRGYVPAEGNKKDDAPVGTLAVDSIYTPVKKVNYQVEPARVGSNDGFDKLTIEIMTNGTIIPEDALGLSARVLIEHLNLFTDLTEVAKATEVMKETEKVNDEKVLDRTIEELDLSVRSYNCLKRAGINTVFDLTEKSEPEMMKVRNLGRKSLEEVKVKLADLGLGLKNDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: LEUD_PYRIL
Sequence: MKIRGRAIVYGDKIDTDVIIPAKYLVYTDPNILGQHAMEPIDPEFPKKAKGAILVAGRAFGMGSSREQAAIALKGAGVLAVVAESFARIFFRNAINIGLPVLQVPEITKKVKEGEELEVDIENGYCINLATGEKIEGKPIRGLPLAILKAGGLTNYLKSLR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: HEMH_CHLTA
Sequence: MVTYLLANFGGPRTSQEIVSFLQALLTDRDVTGGMIPSMLHRPLFSYIAKRRAPHVARQYAYLGGGSPIFQDTERLAQNLSQELQASVIPFHRYLPETHRETLQALQESQGSIVGIPLFPHYTFAVTGSIIRFFLQHLPEKPISWITQFGVHPEFVSCMQQHIRDCLAAQQIAVEDCYFLFSVHGLPQRHIRLGDPYAQQCQASFEALRGELEGKIAFQSKFGIGKWLDPSTQEVCQSLRTKKRHIVIVPFGFVSDHIETLHEIDHLYVPILLQKGYRVVRIPAINASSRWVSSLAAIVRSSPQETSLEPLLMP
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUTC_MACCJ
Sequence: MERGTIHNKGSFLSNISKNLQREMPQHVERPEWQYRPQDKTLTGLTQDELLEVLRQQCNFIHTDLVETTTDNINETLSQVIEKYGNGEVIAWNDKRFADFGIDLEAHDAFIWDEAKGAENLQVAERANVGITFSDVTLAESGTVVLYADKGKGRSVSLLPATYIAIVPKSTIVPRFTQAAQQMNAMMEDQENFPTCINLITGPSNSADIEMKLVVGVHGPIKATYIVVDDK
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
What are the official names of this protein?
Lactate utilization protein C.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: LSPA_BARHE
Sequence: MTRKSFPFFLLGLILTVGIDQAVKYWVMHNIPLGTETPLLPFLSLYHVRNSGIAFSFFSSFSHWGLIFLTLIILIFLLWLWKNTQYNKSLTRFGFTLIIGGAIGNLIDRICFYYVIDYILFYINDVFYFAVFNLADTFITLGVIAIIIEELLSWIKRKSTFSE
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UL32_HHV8P
Sequence: MFVPWQLGTITRHRDELQKLLAASLLPEHPEESLGNPIMTQIHQSLQPSSPCRVCQLLFSLVRDSSTPMGFFEDYACLCFFCLYAPHCWTSTMAAAADLCEIMHLHFPEEEATYGLFGPGRLMGIDLQLHFFVQKCFKTTAAEKILGISNLQFLKSEFIRGMLTGTITCNFCFKTSWPRTDKEEATGPTPCCQITDTTTAPASGIPELARATFCGASRPTKPSLLPALIDIWSTSSELLDEPRPRLIASDMSELKSVVASHDPFFSPPLQADTSQGPCLMHPTLGLRYKNGTASVCLLCECLAAHPEAPKALQTLQCEVMGHIENNVKLVDRIAFVLDNPFAMPYVSDPLLRELIRGCTPQEIHKHLFCDPLCALNAKVVSEDVLFRLPREQEYKKLRASAAAGQLLDANTLFDCEVVQTLVFLFKGLQNARVGKTTSLDIIRELTAQLKRHRLDLAHPSQTSHLYA
What is the function of this protein?
Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA (PubMed:29875246).  Facilitates thereby the transfer of newly replicated viral genomes to the packaging motor (PubMed:33554858).
What are the official names of this protein?
Packaging protein UL32 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL32 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Localizes to viral replication compartments.
Protein: CZS7_CRUCA
Sequence: MAKLKKSLFLVLFLGLVSLSICEEEKREEENEEVQEDDDQSEEKRGFLDVVKHVGKAVGKAALNAVTEMVNQAEQ
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Cruzioseptin-7, CZS-7.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Cruzioseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AAE11_ARATH
Sequence: MDNLVLCEANNVPLTPITFLKRASECYPNRTSIIYGQTRFTWPQTYDRCCRLAASLLSLNITRNDVVSILAPNVPAMYEMHFSVPMTGAVLNPINTRLDAKTIAIILRHAEPKILFVDYEFAPLIQEVLRLIPTYQSQPHPRIILINEIDSTTKPFSKELDYEGLIRKGEPTPSSSASMFRVHNEHDPISLNYTSGTTADPKGVVISHQGAYLSALSSIIGWEMGIFPVYLWTLPMFHCNGWTHTWSVAARGGTNVCIRHVTAPEIYKNIELHGVTHMSCVPTVFRFLLEGSRTDQSPKSSPVQVLTGGSSPPAVLIKKVEQLGFHVMHGYGLTEATGPVLFCEWQDEWNKLPEHQQIELQQRQGVRNLTLADVDVKNTKTLESVPRDGKTMGEIVIKGSSLMKGYLKNPKATSEAFKHGWLNTGDIGVIHPDGYVEIKDRSKDIIISGGENISSIEVEKVLYMYQEVLEAAVVAMPHPLWGETPCAFVVLKKGEEGLVTSEGDLIKYCRENMPHFMCPKKVVFFQELPKNSNGKILKSKLRDIAKALVVREDDAGSKKVHQRSIEHVSSRL
What is the function of this protein?
Butyrate--CoA ligase that is active in vitro with medium-chain fatty acids, with a preference for hexanoate and octanoate.
What are the official names of this protein?
Butyrate--CoA ligase AAE11, peroxisomal, Acyl-activating enzyme 11, Butyryl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: RUVB_LACDA
Sequence: MTEEHLTSQEAAEGEEAVELSLRPQLLSQYIGQGHVKKDMEVYIQAARQRDEALDHVLLYGPPGLGKTTLAFVIANELGVNLKSTSGPAIERAGDLVALLTDLEPGDVLFIDEIHRLAKPVEEVLYSAMEDFYIDIVVGEGQTTHAIHLPLPPFTLIGATTLAGQLSAPLRDRFGIVEHMQYYQVEDLEKIILRSSEVFHTKISPQAAHELARRSRGTPRVANRLLKRVRDFAEVKGEKEISLETTAMALKQLQVDSAGLDQTDRKLLRTMILSYGGGPVGIRTLASNIGEDRETIESLYEPYLLQNGFIVMTPRGRVVTQKAYQQLNLPLPGEEE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.