PharMolix/UniProtQA huggingface dataset:
Protein: FEN_NITMS
Sequence: MGLNLKDLVVREKTTLEAFSNKVIAIDAYNAIYQFLASIRGPDGLQLSDSEGRITSHLSGLLYRNVNFLSLGIKPVYVFDGKPPSLKTAEIERRKQIKMDATIKYEKAIADGNMEDARKYAQQTTSMKDGMVKESKQLLTYFGIPYIEAPSEGEATAAHLTNTGQAYASASQDFDSILCGAKRLVRNFTNSGRRKIPNKNTYIDIVPEIIETQKTLDSLELTREELIDVGILIGTDFNPNGFERVGPKTALKMIKQHSKLEEIPQIQEQLEEIDYQEIRKIFLNPEVADVKEIVFENVNYEGMSNYLVRERSFSEDRVNSTLNRLKKALEKKSQNLDQWF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: ENO_BLOFL
Sequence: MPEIVNIISREIVDSRGNPTVESEVHTKSGFFGLASVPSGSSLGSQEALELRDNDHARFFGKGVKKSVNIINSTIRVSLLNIDVTKQSVIDEIMINLDGTNNKSQLGANSILSVSLAIAKAAASFMGMPLYQYIARLYGMSSNVYSMPVPMMNIMNGGKHADNNLDIQEFMIVPVGAKNIKQAIQMGSEISYSLKNVLNNLGISIALGDEGGYAPNLKSHSYALELINKSIEQSNYVLGKDVVLAIDCAASELFEVSTGKYVINSEKVSFTSEEFVDYLSSLARKYCIFSIEDGQSEHDWHGFSYLTKKLGDIMQLVGDDLFVTNPNLLKMGINKNVANSILVKPNQIGSLTETLNVIKLAKESGYSTIVSHRSGETEDTSIADIAVGTSAGQIKTGPVRCSERTSKYNRLIRIEEFLKDNSKFYGVNEIKNLSAQLWMYQNKNMNI
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: KTU_DROGR
Sequence: MSATSTRNKHSKIHGNEKVDITKDEFARMRLALQDEEFRKLFFDYVDEIQDPENRKIYEQEITQLEKERGVDVTFIHPKPGFVVKTAIDGELKCFINICGSQIVERPNNEVAINSETGERGLTWSIPMAQAPARDDIDANKKLCKVFDVVFHPDALHLGTRNSQFRKCLIDTALDGVEREFNVNLDRANLKYPKLDYKGEPHATVIRKLSKNATAEEREPHPLEHTYPKKPEANAGKPKVLPMKKNVTSTPTFAVPKYSIKHSHDIDMAQYTDELDAKLQVTIPRALIVEIELPLLSSTADCQLDVTEKSVYLLSERSGAKYRLKLDLPYTVDDKSGNARFDTEHRRLCITLPVVRSSAREQRQMHDNVRILSREDSGVELNSNSESPAEDEEAGSEAIVELTTMQQTQTDNFDAFPPRQSFLKRDLHYQMVANFDCNIVENVMAFLLHVPNVQPDSMRTVIREGRSVHLQFASMGSGYYPTNYAFLVQLPDAADPQLHIDHVEPDASDDNVVLRLFMSESCMTLPSYLAGPDATDLTEYACFPPCKTNIEDENCDLELDKPLRISTYHNELNKSIEVTIIPQDISEQVHQEQQQEEEEEEEQHEQQQHQHKKGNKKQRKRNKKQRSLSESAFEDLKAEQQQQHQKQQQQQEKLPENSSPESLNAGSSEPVATLKLPQRKQRSFSECNDSSSVQRGILKRFSRYGPRPSISESSSSIDDCSSSYSCSVDAAGIGFSHSFGGIPEERVIADAELSESCKKTVRFNDHIMKKMFRLDSSILGQRKKNQKRRDCKLRAQQRRVSEGDSVDYEEVEHASNGQQTANKTAANAQYFKQPQNNNNRSYSKNNKNQSLHDSGLDLTNNNNHNNEEDTKRNEADAKNAMIFEMDDDDDEDM
What is the function of this protein?
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella.  Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
What are the official names of this protein?
Protein kintoun, Dynein assembly factor 2, axonemal homolog, PP1-interacting protein 20.
What is the protein family that this protein belongs to?
Belongs to the PIH1 family. Kintoun subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX146_LYCSI
Sequence: MKFVLLFGVLLVTLFSYSSAEMLDDFDQADEDELLSLIEKEEARKDCIPKHHECTSNKHGCCRGHLFKYKCQCTTVVTQSREETERCFCGTPPHHKAAELVVGFGKKIFG
What are the official names of this protein?
U1-lycotoxin-Ls1dd, Toxin-like structure LSTX-A46.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 03 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: UBP10_YEAST
Sequence: MTTQESIKPLVDRILSNPLQFNAAMISNKSNNNDTSAAPENSSYIVIGKQHNNNSNSTAIAATAESKQIKENNLIDRPNGKKTNTVPKSMAEALLLYTSKNDKDAADATGAKKSAELSTELSTEPPSSSSEDDKVGKEEEEEGEIFHEARDYVEPRKASLKERDNADKGDGEDIGEDIGEDIGEDIGEDIGEDIGENLGSPLATIDDSSNENEKEKRKELSTSISSDDEIEDDEDEDDMDYDSSAMEKELPEEEENDSSSKISEGEKKSLYQDLMENSTVEVNRYEPVNNTKENGNRNPKGEEEEEEEEELKHKSRSITPPVTISNLSNFYQFNENINDRGSLNSTRIVKNWGDKFTNLKPRGLLNHGVTCYTNAAVQAMLHIPSIQHYLFDILMGKYDSTISKNSVSYTLAETSKKMWLPVSKNPRKNVSASYINPKHLISRLDDINCMMSEWQQEDSHEYFMSLMSRLQEDSVPKGHKLIESIIYDIFGGLLKQIVTCKSCGSISKTEQPFYDLSLHLKGKKKLDPNSDLSSDSINGTSATTSTTTSNAATKPSLSSSSSVNLNNGSPFAAASDLSSANRRFSIEKSIKDFFNPELIKVDKEQKGYVCEKCHKTTNAVKHSSILRAPETLLVHLKKFRFNGTSSSKMKQAVSYPMFLDLTEYCESKELPVKYQLLSVVVHEGRSLSSGHYIAHCKQPDGSWATYDDEYINIISERDVLKEPNAYYLLYTRLTPKSVPLPLAKSAMATGNVTSKSKQEQAVNEPNNRPLKINSKKNNRKKWKKNKKRKFTK
What is the function of this protein?
Deubiquitinating enzyme involved in telomere and HM loci silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes (PubMed:9755194, PubMed:10490600, PubMed:14623890).  Targets histone H2B for deubiquitination, thus helping to localize SIR2 to the telomere (PubMed:15721261, PubMed:17028327, PubMed:22056669).  At silent chromatin, including telomeres and the rDNA locus, not only maintains low H2B 'Lys-123' ubiquitination (H2BK123Ub), but also low H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively) (PubMed:15721261, PubMed:15988024).  Controls the proliferating-cell nuclear antigen PCNA/POL30 deubiquitination which is crucial for keeping TLS polymerases in check as well as for down-regulating the error-free bypass (PubMed:22829782).  Deubiquitinates and stabilizes RPA190, the largest subunit of RNA polymerase I, to achieve optimal levels of ribosomes and cell growth (PubMed:22902402).  Protects also nutrient transporters such as GAP1 from ubiquitin-dependent endocytosis (PubMed:11352638).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 10, Deubiquitinating enzyme 10, Disrupter of telomere silencing protein 4, Ubiquitin thioesterase 10, Ubiquitin-specific-processing protease 10.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere. Nucleus, nucleolus. Note=Preferentially localizes to silent chromatin (PubMed:15988024).
Protein: UBIC_BURPS
Sequence: MRFDAADAHWRETPRPGASSAQKDWLTRGGSLTAHLARLGRVTVRVTRETVAAPWADEHRALSCASRAPVWVREVVLAVDGAPFVAAHSIAPLAASKGVWQAMRRLRTRPLAELLYSDPEVTRSALVSRRVLAGHPLFSLASLALARAYATEHAFAARRSVFERRGTPLMVTECMLPALWRHLDAHGERRARGLEQT
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABA_EDWI9
Sequence: MVDKRESYTKTDLEASGRGELFGAGGPPLPSGNMLMMDRVIKMTEDGGSHNKGYVEAELDINPDLWFFACHFVGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRVINRKLIMGLADGEVLVDGKLIYTANDLKVGLFKDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2B2_ARATH
Sequence: MSDAFCSDCKRHTEVVFDHSAGDTVCSECGLVLESHSIDETSEWRTFANESGDNDPVRVGGPTNPLLADGGLTTVISKPNGSSGDFLSSSLGRWQNRGSNPDRGLIVAFKTIATMADRLGLVATIKDRANEIYKRVEDQKSSRGRNQDALLAACLYIACRQEDKPRTVKEICSVANGATKKEIGRAKEYIVKQLGLETGQLVEMGTIHAGDFMRRFCSNLGMTNQTVKAAQESVQKSEEFDIRRSPISIAAAVIYIITQLSDEKKPLRDISVATGVAEGTIRNSYKDLYPHLSKIIPAWYAKEEDLKNLQSP
What is the function of this protein?
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
What are the official names of this protein?
Transcription initiation factor IIB-2, General transcription factor TFIIB-2, AtTFIIB2.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUOB_GEOSL
Sequence: MGVDQPLGDNFITTSLDSLVNWARKSSIWPMTFGLACCAIEMMATGASHNDLDRFGIIFRASPRQSDCIIIAGTVTKKMLPVIKTVYEQMPEPKWVVAMGACACSGGVFDTYSVVQGIDTALPVDVYIPGCPPRPEALLYGLLKLQDKIMKDKNSFGSTIGLGERLESAA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL5_STRPF
Sequence: MANRLKEKYTNEVIPALTEKFNYTSVMAVPKVEKIVLNMGVGDAVSNAKNLEKAAAELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLDKLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEISFDDVDKVRGLDIVIVTTANTDEESRELLKGLGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: MAZF6_MYCTO
Sequence: MVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTAIVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Acts as an endoribonuclease on single-strand RNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU.  Neutralized by coexpression with cognate antitoxin MazE6.
What are the official names of this protein?
Endoribonuclease MazF6, Toxin MazF6, mRNA interferase MazF6.
What is the protein family that this protein belongs to?
Belongs to the PemK/MazF family.
Protein: NUOB_HELPS
Sequence: MQQAPVVLSTLDKLLNWGRSNSLWPLTYGLACCAIEMMATGGSRFDFDRFGTIFRASPRQSDVMIIAGTLTKKHAEFMRRLYDQMPEPKWVISMGSCANTGGMFNTYATVQGADRVVPVDIYLPGCAPRPETLQYALMVLQDKIRRSKAIKQDAPKRLV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EXOD_ECOLI
Sequence: MKFRLGGFEAIKSAYMAQVQYSMWVTRKDAWYFANYDPRMKREGLHYVVIERNEKYMASFDEMVPEFIEKMDEALAEIGFVFGEQWR
What are the official names of this protein?
Putative uncharacterized protein ExoD.
What is the protein family that this protein belongs to?
To bacteriophage lambda exonuclease exo.
Protein: RL7_AROAE
Sequence: MAISKEDILEAVGSMTVMELNDLVKAFEEKFGVSAASMAVAAPGAGAAAAPVEEKTEFDVILLAAGEKKVEAIKVVRAATGLGLKEAKDLVDGAPKAVKEGISKADAEAIKKQLEDAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: LIPB_SHEPA
Sequence: MYDNALHIRHLGKQDYESVWHAMQHYTDNRDENSQDEIWIVEHTPVFTQGQAGKSEHILNPGDIPVIQVDRGGQVTYHGPGQLVVYPLLDIKRLKVGVRQLVTHIEQSIINMLKRYQIEAYAKADAPGVYVEERKIASLGLRIRKGCSFHGLALNVDMDMSPFQRINPCGYAGMEMIQCKQLGGPQTVEEAGAQLIETLSQELGLDKLVHHQGLPESYE
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHG24_HUMAN
Sequence: MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
What is the function of this protein?
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization.  Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state.  Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity.  Able to suppress RAC1 and CDC42 activity in vitro.  Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia.  Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
What are the official names of this protein?
Rho GTPase-activating protein 24, Filamin-A-associated RhoGAP, FilGAP, RAC1- and CDC42-specific GTPase-activating protein of 72 kDa, RC-GAP72, Rho-type GTPase-activating protein 24, RhoGAP of 73 kDa, Sarcoma antigen NY-SAR-88, p73RhoGAP.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
Protein: CHOD_MYCTO
Sequence: MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLNYANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEPVRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIPIGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSNAG
What is the function of this protein?
Likely catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process.  Required for virulence.
What are the official names of this protein?
Cholesterol oxidase, Cholesterol isomerase.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family. Highly divergent.
Protein: THTR_CRIGR
Sequence: MVHQVLYRALVSTKWLAESIRSGSLGPGLRVLDASWYSPGTRQARKEYQERHVPGASFFDIEECRDTTSPYEMMLPSEAHFADYVGSLGISNDTHVVVYDGDNLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLQSKRFQLVDSRAQGRYLGTEPEPDIVGLDSGHIRGSANMPFMNFLTEDGFEKSPEELRAIFQDKKVDLSQPLIATCRKGVTACHIALAAYLCGKPDVAVYDGSWSEWFHQAPPETRVSQGKSGKA
What is the function of this protein?
Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA.  Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity).  Formation of iron-sulfur complexes and cyanide detoxification.  Binds molecular oxygen and sulfur.
What are the official names of this protein?
Thiosulfate sulfurtransferase, Rhodanese.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: LECS1_MYTVI
Sequence: MSSVTIGKCYIQNRENGGRAFYNLGRKDLGIFTGKMYDDQIWSFQKSDTPGYYTIGRESKFLQYNGEQVIMSDIEQDTTLWSLEEVPEDKGFYRLLNKVHKAYLDYNGGDLVANKHQTESEKWILFKAY
What is the function of this protein?
Galbeta1-3GalNAcbeta1-4Galbeta1-4Glc oligosaccharide-binding lectin.  Binds strongly to the oligosaccharides of ganglioside GM1b and to a lesser extent its precursor asialo-GM1 (PubMed:31769916, PubMed:33328520).  Binds weakly to asialo-GM2 oligosaccharide and to the glycan moiety of globo-series stage-specific embryonal antigen 4 (SSEA-4) hexaose (PubMed:31769916).  Binds galactose, N-acetylgalactose and lactose.  Does not bind GM1 (PubMed:33328520).  Does not bind to Gal-beta1,3-GalNAc (Thomsen-Friedenreich antigen), the oligosaccharide of GM1a ganglioside or SSEA-4 tetraose.  Does not bind to N-glycans, O-glycans or glycosaminoglycans of glycoproteins.  Does not bind Lewis glycans, derivatives of lactose or N-acetyllactosamine or blood group (ABH-type) oligosaccharides (PubMed:31769916).  Does not bind glucose (PubMed:33328520).  Has hemagglutination activity towards rabbit erythrocytes (PubMed:31769916, PubMed:33328520).  Displays cytotoxic effects against various cultured cell lines including human breast (MCF-7), cervical (HeLa) and colon cancer (Caco2) cell lines, as well as dog kidney (MDCK) cell line that express asialo-GM1 oligosaccharide at their cell surface.  Shows dose- and time-dependent activation of MKK3/6, ERK1/2 and p38 MAPK, as well as caspase-3/9 in HeLa cervical cancer cells.  No cytotoxic effect on BT474 human breast cancer cell line.  May be involved in recognition of glycans found on parasitic or symbiotic microorganisms (PubMed:31769916).
What are the official names of this protein?
GM1b/asialo-GM1 oligosaccharide-binding R-type lectin, R-type lectin 1, SeviL, SeviL-1.
Protein: PA2B3_LATSE
Sequence: NLVQFTYLIQCANSGKRASYHYADYGCYCGAGGSGTPVDELDRCCKIHDNCYGEAEKMGCYPKLTMYNYYCGTQSPTCDDKTGCQRYVCACDLEAAKCFARSPYNNKNYNIDTSKRCK
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 3, svPLA2, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 isozyme III.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPF_ENTFA
Sequence: MNVMMQKVHGSENDFFLLDETQFERSLTAEEIEQLRIQLCSRETGLLAGADGLLLVGEGTHGTSNARMRVINSDGSEASMCGNGLRTVARYLAEKNQEKSFTVETMFADLKVRQAPNLAEEVATYQVEISPVSFEAVTIPMHLGVQTLIDEIVPALSNTIRFTAVAVPNPHLVAFVDHETLNGPEFERIATYVNNENPYFPEGINVSFVEILGKNQLFVRTYERGVGFTSACGTAMCASSLLYTLLKDGVFYEEITVKNTGGMVKTVVHETSDGSYWMELIGNATITHLIEGSLTDLLNGAFEKITITETNEQKHYQEFLQTLSQK
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBSAG_WHV3
Sequence: MGNNIKVTFNPDKIAAWWPAVGTYYTTTYPQNQSVFQPGIYQTTSLINPKNQQELDSVLINRYKQIDWNTWQGFPVDQKLPLVSRDPPLKPHINQSAQTFEIKPGPIIVPGIRDIPRGLVPPQTPTNRDQGRKPTPPTPPLRDTHPHLTMKNQTFRLQGFVDGLRDLTTTERYHNAYGDPFTTLSPVVPTVSTILSPPSTTGDPALSPEMSPSSLLGLLAGLQVVYFLWTKILTIAQNLDWWWTSLSFPGGIPECTGQNSQFQTCKHLPTSCPPTCNGFRWMYLRRFIIYLLVLLLCLIFLLVLLDWKGLIPVCPLQPTTETTVNCRQCTLSVQDTYTPPYCCCLKPTAGNCTCWPIPSSWALGNYLWEWALARFSWLNLLVPLLQWLGGISLIAWFLLIWMIWFWGPALLSILPPFIPIFVLFFLIWVYI
What is the function of this protein?
The middle envelope protein plays an important role in the budding of the virion.  It is involved in the induction of budding in a nucleocapsid independent way.  In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
What are the official names of this protein?
Large envelope protein, L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus major surface antigen family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: F261_HUMAN
Sequence: MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
What is the function of this protein?
Synthesis and degradation of fructose 2,6-bisphosphate.
What are the official names of this protein?
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, 6PF-2-K/Fru-2,6-P2ase 1, PFK/FBPase 1, 6PF-2-K/Fru-2,6-P2ase liver isozyme.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the phosphoglycerate mutase family.