PharMolix/UniProtQA huggingface dataset:
Protein: LUXS2_LACDB
Sequence: MAKVESFTLDHTKVKAPYVRLITEETGKKGDVISNYDLRLVQPNTNAIPTAGLHTIEHLLAGLLRDRLDGVIDCSPFGCRTGFHLITWGEHSTTEVAKALKGSLDAIANDIEWKDVQGTDKYSCGNYRDHSLFSAKEWSKEILSQGISDQPFERHVI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase 2, AI-2 synthesis protein 2, Autoinducer-2 production protein LuxS 2.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: SYLA_AQUAE
Sequence: MMKEFNPREIEKKWQKRWEEAGVFKAQEGKPNKFYVLEMFPYPSGRIHMGHVRNYTIGDAIARYLKMRGKNILHPMGWDAFGLPAENAAIKHGIHPAKWTYENIDYMKKQLKILGFSYDWDREIATCDPEYYKWNQWIFLKMLERGIAYRKTAKVNWCPHDQTVLANEQVIEGKCWRCGTPIVQKEVPSWFLRITAYADRLLEDLKKLEGKWPERVIAQQRNWIGRSEGALIRFYVEIEEPEKFLNCVPEELKETLLKEKRIYIDVFTTRPDTVFGATFVVLAPEHPLVPVLACIGERLGNACYSDVENFVEKMKKMSTRERTMEEDKEGVFLGVYATNPANGEKIPVWSANYVLYEYGTGAIMCVPAHDQRDWEFAKKYDLPIKVVVKPEGAWDFEKGAYEGKGTLVNSDGFDGLDSETAKRKITEWLQDRGLGEKKVSYRLRDWNISRQRYWGTPIPVVYCEKCGMVPVPEDQLPVKLPLDVKFTGQGNPLETSEEFVNTTCPKCGGKARRETDTMDTFFDSSWYFLRFCDPKNDREPFSREKVDYWMPVDVYIGGIEHAVLHLLYARFFQKFLKDLGLVRDDEPFEKLITQGMVLKKWVSVKKLLDYLGLSEEDEVEELKKRLEELGARRA
What are the official names of this protein?
Leucine--tRNA ligase subunit alpha, Leucyl-tRNA synthetase subunit alpha, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_AGRVS
Sequence: MSRIGKKPVQVPAGITASVDGQKVTAKGPKGELFFVANDEISVALEDNAIVVKPVNDSKDARSKWGMSRTMIENILKGVKDGYERKLEINGVGYRASLQGKNLQLALGFSHDVVYEPPQGITIAVPKPTEIVVSGINKQQVGQVAAEIREYRGPEPYKGKGVKYAEERIVRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NAMA_CLOAB
Sequence: MKIFEAYTIKNMCLKNRIVMPPMCMYSSDNTGNINDFHLVHYTTRSIGGVGFIIVEATGITPNGRISDKDLGIWSEKHAEGLSFLVKEVKKYGSKIAIQLNHSGRKYEGTSGEPVAPSALAFDENSKTPKELTKNEIKEIILAFKAAAKRAEKAGFDAIEIHGAHGYLINQFLSPLSNFRDDEYGGSTENRTRFLKEVLEAVREVWPKEKPILLRVSAEDYRGGSGITPNEMVNIINIVKDLIDVVDVSSGGVAPAHINLYPGYQVKLSEVIKNECNVPTIAVGLICDINMVEEILSNNRADLVALGRELLRNPYFVLSSARLKNINIDFPKPYERAFN
What is the function of this protein?
Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones.  It also reduces the nitro group of nitroester and nitroaromatic compounds.  It could have a role in detoxification processes.
What are the official names of this protein?
NADPH dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.
Protein: RECR_CUPPJ
Sequence: MKAAPPTSLQALIEALRVLPGVGPKSAQRMAYHLLQHDREGARKLGDALRGAADHIRHCARCNTFTEQEICETCLDDRRDGSILCVVETPADQIMIEQTLTYRGKYFVLMGRLSPLDGIGPKEIHLDRLLARATDTEMGGPVGEVIVATNFTSEGEATAHYIGEMLKARGLKVSRLARGVPVGGELEYVDAGTIARAVMDRRNL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: TBD_XENTR
Sequence: MSVVTVQLGQCGNQVGYEFFDILCSDLHSKPGHSTKRENDYYQTVCKEQFFHEEECGDLVTRAVLVDMEPKVVSKTLSMAGRSGKWKYDISSQFSQKQGCGNNWANGYCVHGPKHQDIVMDLVRKQVEKCDRLGGFFTIMSMAGGTGSGMGTFLTRCLRDAYPDSLLLNQVIWPYGTGEVIVQNYNSILTLSHLYRSSDALLVHENDIIHKVCSQLMNIKQISFRDVNKVIAHQLGSIFQPVYTSEEALHYCRNPLGELMECLVPHPEYKMLGLRNIPQMSEHSLAYSTFNWNGLLKHLRQMLIANAKMEEGINWHVRPPSQPTAEKTSLRKELQFNTSVANLAILRGKDVQTASLEGFRDPPLYTPWLSPDDAFTLWKTPRAFNKYEKSATLVSNSQFLLKPLDNIVGKAWNMFASKAYVHQYTKFGIDEEEFLETFTTLEQIIASYTNL
What is the function of this protein?
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
What are the official names of this protein?
Tubulin delta chain, Delta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Note=Associated with centrioles. Both cytoplasmic and nuclear. In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.
Protein: RDGC_ECOHS
Sequence: MLWFKNLMVYRLSREISLRAEEMEKQLASMAFTPCGSQDMAKMGWVPPMGSHSDALTHVANGQIVICARKEEKILPSPVIKQALEAKIAKLEAEQARKLKKTEKDSLKDEVLHSLLPRAFSRFSQTMMWIDTVNGLIMVDCASAKKAEDTLALLRKSLGSLPVVPLSMENPIELTLTEWVRSGSAAQGFQLLDEAELKSLLEDGGVIRAKKQDLTSEEITNHIEAGKVVTKLALDWQQRIQFVMCDDGSLKRLKFCDELRDQNEDIDREDFAQRFDADFILMTGELAALIQNLIEGLGGEAQR
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: KITH_BOVIN
Sequence: MSCINLPNVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQVAQYKCLVIKYAKDTRYSSLFSTHDRNTMEALPACLLRDVIQDAQRVAVIGIDEGQFFPDIVEFCENMANSGKTVIVAALDGTFQRKAFGTILNLVPLAESVVKLTAVCMECFREAAYTKRLGVEKEVEVIGGADKYHSVCRLCYFKKASGQPAVLDSEENKENCPMTLGKPAEAPGVRKLFATHQIWQCSQAN
What is the function of this protein?
Cell-cycle-regulated enzyme of importance in nucleotide metabolism.  Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate.  Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration.
What are the official names of this protein?
Thymidine kinase, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBAB_SHIDS
Sequence: MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein YbaB.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL21_ECOSE
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: FOS_TAKRU
Sequence: MMFTSFNAECDSSSRCSASPVGDNLYYPSPAGSYSSMGSPQSQDFTDLTASSASFIPTVTAISTSPDLQWMVQPLISSVAPSHRAHPYSPSPSYKRTVMRSAASKAHGKRSRVEQTTPEEEEKKRIRRERNKQAAAKCRNRRRELTDTLQAETDQLEDEKSSLQNDIANLLKEKERLEFILAAHQPICKIPSQMDTDFSVVSMSPVHACLSTTVSTQLQTSIPEATTVTSSHSTFTSTSNSIFSGSSDSLLSTATVSNSVVKMTDLDSSVLEESLDLLAKTEAETARSVPDVNLSNSLFAAQDWEPLHATISSSDFEPLCTPVVTCTPACTTLTSSFVFTFPEAETFPTCGVAHRRRSNSNDQSSDSLSSPTLLAL
What is the function of this protein?
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.  FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton.  It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity).
What are the official names of this protein?
Protein c-Fos, Cellular oncogene fos, Transcription factor AP-1 subunit c-Fos.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Fos subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ABHD4_BOVIN
Sequence: MADDLEQQPQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSLPNQNKIWTVTVSPELRDRTPLVMVHGFGGGVGLWILNMDSLSTRRTLHTFDLLGFGRSSRPTFPRDPEGAEDEFVTSIETWRESMGIPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPADPSQVRAPPTWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFDDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGANTWIDTSTGKKVKLQRPDSYVRDLEIEGASHHVYADQPHIFNAVVEEICDSVD
What is the function of this protein?
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE).  Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis.  Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains.  Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.
What are the official names of this protein?
(Lyso)-N-acylphosphatidylethanolamine lipase, Alpha/beta hydrolase domain-containing protein 4, Abhydrolase domain-containing protein 4, Alpha/beta-hydrolase 4, Protein ABHD4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
Protein: BTNL3_HUMAN
Sequence: MAFVLILVLSFYELVSGQWQVTGPGKFVQALVGEDAVFSCSLFPETSAEAMEVRFFRNQFHAVVHLYRDGEDWESKQMPQYRGRTEFVKDSIAGGRVSLRLKNITPSDIGLYGCWFSSQIYDEEATWELRVAALGSLPLISIVGYVDGGIQLLCLSSGWFPQPTAKWKGPQGQDLSSDSRANADGYSLYDVEISIIVQENAGSILCSIHLAEQSHEVESKVLIGETFFQPSPWRLASILLGLLCGALCGVVMGMIIVFFKSKGKIQAELDWRRKHGQAELRDARKHAVEVTLDPETAHPKLCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQGFQAGKHYWEVDVGQNVGWYVGVCRDDVDRGKNNVTLSPNNGYWVLRLTTEHLYFTFNPHFISLPPSTPPTRVGVFLDYEGGTISFFNTNDQSLIYTLLTCQFEGLLRPYIQHAMYDEEKGTPIFICPVSWG
What are the official names of this protein?
Butyrophilin-like protein 3, Butyrophilin-like receptor.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. BTN/MOG family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GPI13_ASHGO
Sequence: MQEQIEGAVDEELLKQSVLNNDEDDRRLTKLRIERFRTTHTLYIFLYSALAALQFIAIAFFTRGFLLSRKVLDDVANRDESTAPAKFDRLVLLVVDALRFDFVIPVDVAAEGYNSHYHNHLRALYERWDESILLKFLADPPTTTLQRLKGLTTGSLPTFIDAGSNFNGDVIDEDNIIKQMCLNNKTIYFAGDDTWDALFHPYLSNVSMPYESLNVWDLDTVDNGVISFFEDHLLNNPTEKKEWDVLVGHMLGIDHVGHKYGPSHFSMAEKQSQVDGFIRQIIDAVDEDTLLVVMGDHGMDHTGNHGGDSPAELESTLWLYTKRPGTWRRQAPAAYNTTELGRYYRAVNQIDLVPSLSLLLGLPIPFNNLGWPIEELAHDDDEWRLFTRQTLMQLETYRNTSNSITDSSKLKILEELKINANSNSSDAGNYQAILLEMYKDLWARFDYYSIGTGIILLIISLAMLITITRLIPSIVVGQMLSELVPTIIVMPLVSNVCFLGVFYVLRQPAFLQNWLWASLLATAVGIIIGFYVPIFDRYNLTWLVLRFGEELSDYWSRVAAFLITLHALIFTSNSFTIWEDKIVSFSLTTLGMLTLYEFVFLPKRHSTSAILAAALGEKEGTVSGISSGQANSDSLPLGRFARIVGGYHSIVLIVCTRLASLITICREEQGAYCTPTFTLTNNYSFSVMLGCLFLVFATPACIKGYYNVSSSYQAAAPIWIGMLMKSILFVNFIYWELKTFENTSDTHGLNLTIFNLTISRIVVGVSLVAANIGWMMGPLCIKLNVHNNDRRSQQATILGYANAYGAQYFLLVINFFMCILLFNKPLAQLSLFLMCNQLLSILEIFDLLKLKENLIGPVALGLLSYQQFFSTGHQATIPAVQWDMGFILTERITFPFTHLGIVLNTFGPHILCGISVALLTLWKQPPGILRANTLLARVVSNCGMLLIYQTVLCLSTFIWVTNFRRHLMVWKIFCPRFMFAALSLIVTQLVLTFITIAFASGRLIKQIDRMFWK
What is the function of this protein?
Involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.  Involved in cell wall biosynthesis (By similarity).
What are the official names of this protein?
GPI ethanolamine phosphate transferase 3, Glycosylphosphatidylinositol-anchor biosynthesis protein 13.
What is the protein family that this protein belongs to?
Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: FB211_ARATH
Sequence: MDRVGSLPDELLSHILSFLTTKEAALTSLLSKRWRYLIAFVPNLAFDDIVFLHPEEGKPERDEIRQSFMDFVDRVLALQAESPIKKFSLKCRIGVDSDRVDGWISNVLNRGVSELDLLIILGMTMEDSYRLSPKGFASKTLVKLEIGCGIDISWVAGSIFLPMLKTLVLDSVWFYVDKFETLLLALPALEELVLVDVNWLDSDVTISNASLKTLTIDSDGHLGTFSFDTPSLVYFCYSDYAAEDYPVVKMENLREARIFLLVTDNEIERVRLPINDGLEDAMDNVVLRFGHVGKLMNGIRNVEYLELSADTLEVLSLCCESMPVFKNLKSLAIKSTEGRGWQAMPVLLRNCPHLEFLLIEGLLHHVTDKCGDACDCVPREDKGRSLTSCPVNMLEIHGFRGTKKEMQMIKHFLDYFPSLKEMDIYADEDGPTNLEAPGMFEQITQLFTLYDEFYTCDVQFMVRGSLYKKLTAQCCVFKEENLPHRLVRTLG
What is the function of this protein?
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
F-box protein At3g59000.
What are the subcellular locations of this protein?
Nucleus.
Protein: AAEB_ECOSE
Sequence: MGIFSIANQHIRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTALQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVSAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVHRLAGMLHKYQHALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.