PharMolix/UniProtQA huggingface dataset:
Protein: DXR_NITWN
Sequence: MSAVPLKNDKPVEAGVRTVTVLGATGSIGDSTMDLLRGARGRYRVEALTANSNVEGLVKLAREFDARFVALADTSYFDELKNALAGTGIEYGVGESAIIEAASRPADWLMAAVSGAAGLKPALAAVDRGATIALANKECLVCAGDFFMQRAARAGACVLPADSEHNALFQALSSGNRDELTRVIITASGGPFRTWAAADIENATLAQALKHPNWSMGRKITIDSASMMNKGLEVIEAACLFALEPEEIDVLVHPQSIVHGMVEFSDRSVVAQLGAPDMRTPIAHCLGWPERIAGPAAKLDLVSIGQLTFEAPDFARFPALRLAYDALRTGQGATTVYNAANEIAVAAFIAEKIRFGAIARLVEATLNGWVRAGNLAPLASADDAIAVDHNARNMAASLLPQIAAKAS
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: DNLJ_WOLPP
Sequence: MTDLEKMREKLQNQINYHNILYYQKSKPEISDAEYDELKKKLAAIEPEAYATQDSVGAPPDERFSKVEHQEPMLSLENAYDEQGVEKFLSKIKRFLIADEIEILCEPKIDGLSFSAIYEDGKFVKAATRGDGFVGEDVTHNVATIKGFPKFLQDVQGRLEVRGEIYISNSDFLKLNENNEFANPRNAAAGSLKQLNANITAKRPLRYFAYSLIGGIEKSQSEVLEKLEKLGFCVNEHRSLTSSLNGMLKFYNEIYDCRYNLDYDIDGIVYKVNDLVLQSRLGSTHKAPRSALAYKFSAIYAKTKLNKIFIQVGRTGVLTPVADLVPVNIGGVLVSRASLHNQDEIKRKDIREGDVVTIKRAGDVIPQIVKVDEGSRHTNMPEFVFPDICPECGSKVQIEGVAVRCPEEFNCKAQIVEKLKHFVSKDAFDIVGLGEKQIKFFYDLELIRQIPDIFILEERLKEFSLKEHHGWGEKSIANLLSAIQSRRVISLDRFIFSLGIRFIGQVVAELLANYYVSYDNWYNSMSSNDVELVGIDGIGEKVAESLKSFFSQERNIKMLNDLTAYLQILPVSSNSSDSFLNNKIIVFTGKLRAMSRGEAKVRAKVLGAKISSSLSTKTDYLIAGEDPGSKYKKAMELGVEILDEEQWNRLC
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: CLP1_DROVI
Sequence: MSEDNSHSREYVLEADSELRFEIEQKDAKVLVTLVTGFAELFGTELVKKKKYEFGVGAKVAIFTYQGCVLHVSGKMDVCYISKETPMVQYINCHAALEQFRMEAEERDKRGPVVLIVGPMDVGKSTLCRILLNYAVRVGRRPLYADLDVGQGAISISGNVATILIERPASVEEGFTKTAPLVYHFGHKSPGANNVLYNAVVSKMAEVTLQSLDANKRTKSSGIIVNTCGWVKGSGYAHLLHAARAYRARAVFVLDQERLYNDLLRDVPSNVHVVLLPKSGGVVERSKELRHESREQRVKEYFYGNTRTPFYPFSFEVKFQDLRLYKIGAPPLPDSCMPIGMKAEDNKKKVVPVTPTPSLLHHILTLSFAESTDDDVIGTNVAGFCCVTEVDMDRQSVMLLSPQPRPLPPNALLLWSEIQFMDNHA
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
Protein CLP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: 3MGH_RHOBA
Sequence: MMNDAKRNQFREDDEEDRLIDWGSTQSLQSQFFDRRPAVVARQLLGCGFARRIEGVWVGGWIVETEAYLSSRDAASHSARGEKPGNASMFGRPSTLYVYPIHAKHCVNLVTESVGCGSAVLIRALQPVWGIDRMFQHRGLHRSETTDGRALTTGPGRLCQSLAIDRTCDGVDPIRDPNWCVFSGPKLPSSRVTTTPRIGISQAAELPLRFFVDGNRYVSGLVRHHRRPRRDSL
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: LEU1_CLAMS
Sequence: MKSTQTPSGMPIHKYRPFHEQITVDLRDRTWPARRITEAPRWCAVDLRDGNQALIDPMSPERKRIMFNLLVRMGYKEIEVGFPSASQTDFDFVRSLIEEGAIPDDVTIQVLTQAREHLIARTYESIRGAKQAIVHLYNSTSVLQREVVFRTDRQGIIDIALEGARLCKRYEETIPETDVYYEYSPESYTGTELEFAAEICNRVVEVFDPTPERKVILNLPATVEMATPNVYADSIEWMCRHLDRRDEILVSLHPHNDRGTAVAAAELGYLAGADRIEGCLFGNGERTGNVDLVALGINLFTQGIDPQIDFSDLDGIKRTAEHCNQLAVPERSPWAGDLVYTAFSGSHQDAIKKGFEAMAVDAAAQGVTVDDIPWAVPYLPVDPQDLGRSYEAVIRVNSQSGKGGVAYLLKADHSLDLPRRLQIEFSGVVQAKTDAEGGEVTSAQIWSVFQDEYLPAPLDRVEEKWGRFELTSTRTSSDMGGSVSLDVVLRDGDEVREASASGNGPIAAFLQVLADQGVEVRLLDYVEHALSASGDALAASYVELEVEGVRLWGVGIDEDSSTASLEAIVSGVNRAIRRTVREPELAAV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: HBB_ACCGE
Sequence: VQWAAEEKQLITGLWGKVNVADCGAEALARLLIVYPWTQRFFASFGNLSSATAVLGNPMVRAHGKKVLTSFGEAVKNLDNIKNTFAQLSELHCDKLHVDPENFRLLGDILIVVLAAHFGKDFSPDCQAAWQKLVRAVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RBL_PERAE
Sequence: MSPKTETKASVGFKAGVKDYKLTYYTPDYETKSTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTTLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGQPWGNAPRAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKEIKFEFAEWIPCNQ
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SSP14_PHAJA
Sequence: KPEEDWDRTD
What are the official names of this protein?
Skin secreted peptide P1-4, PjP1-4.
What are the subcellular locations of this protein?
Secreted.
Protein: CB5_ARATH
Sequence: MASLGVSEMLGTPLNFRAVSRSSAPLASSPSTFKTVALFSKKKPAPAKSKAVSETSDELAKWYGPDRRIFLPDGLLDRSEIPEYLNGEVAGDYGYDPFGLGKKPENFAKYQAFELIHARWAMLGAAGFIIPEALNKYGANCGPEAVWFKTGALLLDGNTLNYFGKNIPINLVLAVVAEVVLLGGAEYYRITNGLDFEDKLHPGGPFDPLGLAKDPEQGALLKVKEIKNGRLAMFAMLGFFIQAYVTGEGPVENLAKHLSDPFGNNLLTVIAGTAERAPTL
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein CP26, chloroplastic, LHCB5, LHCIIc, Light-harvesting complex II protein 5.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PAN1_PICGU
Sequence: MYNPYQQPSYGAPQQPQQTGYGFNATGGNAMPQSQFQSTGYYQQQPTYQQPGFQPQQTGFQPQATGYSVPQTSYQTGFQVQQTGFQPQQTGFQQQSAETNTELKIPNIRLSFITASDQSKFEHLFRTAVRKGETAISGDAARDILLRSGLPPVTLAEIWSLSDTNKSGSLLFPEFALSLHLCNLALKSEPLPSVLPEKWSNEVQSFVDAISFSVPEDPSKILANTPFASLGTEEKTSWMDAPAAPSTSFQPQLTGFQPPQMPAQRTGGQITAQRTGGGSLIPLQPQQTAGLVPAGLQRQNTGYQPPQPLQSQNTGFQSSVGRQNTGYQPPLQQQGTGYQPLKQQNTGYQPPLQQQGTGYQPPLQQQGTGYQPPLQQQGTGYQPLQSQGTGFQSQGTIQPQGTGFQPQSTGFQPQPTGLSSQPTGKPGQWGFVSTPTGGIPGLSAMEQHFLPNTQLSSNNLQNAMGGSLKTNVTWAITKQEKSIYDGIFQAWDKSRQGFIDGETAIGIFGKSGLARPDLETIWNLADGDNKGKLNKDEFSVAMHLVYRRLNGFDLPLRLPPELIPPSKKHIQESMDSLKNSLRGGNNKPKRTQTSSSLYKHDDDDVGYVSTARHRKKSDSSSGSGSGTMSIEQLKKEIREKKILLDAMDSEDRDSSVLSQRDREWNEREIESLKFRILQAHNKLESSGISGSHEEKVQLLDRLRHLTQDKMPKLISNIHVVNNEICSRQMKVAKLRLQKEHPDWAPEASDADIVGTGPNGEVTDYDRKKFKSKQLLKRRMAALSGAKTGSTDTAVDDQLAKATEDAKNLGDQQRKMIEEISGSIKDLEDGCISALQSTTREDSYEKWEKGQGVSSDVAAFIRSLPKSEGSKNGRNEKTQSPYTQPTKSQSQSAQSTQSQSQSTQSVQTQPAQPATYSSYSSPEDRAAYIKAQAEKRMNERLAKLGITRRKETGSKAPEVPKEPVEAPKPQEIETPKETETQRETNTKSTSQTSKAEPQKVSVPPAIPSSSQAPAIPSPAIPPAPEDDSEDEEYAALMKQKQEMEERRLRKKKEKEERLARLKREMEEMNKEEDSDEEPVTSVPTYTNGSVKSSTQPISQSEEVPKTEEEKSGESEQTASKPEATPTEQAPKPDLVSTSAQSKANPFSKNNNPFFKPTQTPTIDPKKAAAQRDSQRGLGSDDWSDSDDNSSDDDGPNRAGAARLASMLFGGMAPPPRAPTIEKEETGSKETAEVPPPTEVAPPPVPAAPPASVPPPISAASSKETDSDDEWGTPSAEAANDHDDFDFGNNFEPSMAPSPPPVPTQHIPEPVTDVPPIPQSIPPPPQSFAATVEDAPPPPPIPSQVPPPPPPPPSLFPTESSNAPPAPPPPPPPSAPSAVPPPPPMAPAAPPSAPAPSPGGPPGGAPNIGALLGQITGGKSLKKVDDSQKRIADGATVGRVVD
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein PAN1.
What is the protein family that this protein belongs to?
Belongs to the PAN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: METE_SULAC
Sequence: MSDEITILPTTVIGSYPRPKWLRETIRLHRAGKVNQEDLEEAFNDAVVTVVRDHQEAGIDVPTDGEMRRDEMVEFFAERLSGFKFYGHVRVWGDHYYRKPSVTGKIKYNNPMLLDEVNFAKSVSYTQNLKVTITGPYTISEWSYNEYYKTQRDMAFDLAKVINQEIKNLVDIGIKVIQVDEPAIHTRKEDVEWAIDSINESIKGVNVKVVLHVCYGEYSYLEPHLDKLKVDQINLALKNYNYTPVKLFKKWDREIGVGVIDVHNRKIESVEEVAEDLRKLLEYFKPEMVWVNPDCGLKLLPRKIALQKLINMVKGTLIVREELKKKGYTNTTLKPLINR
What is the function of this protein?
Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation.  The physiological methyl donor is unknown.
What are the official names of this protein?
Methionine synthase, Homocysteine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the archaeal MetE family.
Protein: TOLB_SALPA
Sequence: MKQALRVAFGFLMLWAAVLHAEVRIEITQGVDSARPIGVVPFKWAGPGAAPEDIGGIVAADLRNSGKFNPLDRSRLPQQPATAQEVQPTAWSALGIDAVVVGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYAGHTASDEVFEKLTGIKGAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGTKLAFALSKTGSLNLYVMDLASGQIRQITDGRSNNTEPTWFPDSQTLAFTSDQAGRPQVYKMNINGGAAQRITWEGSQNQDADVSSDGKFMVMVSSNNGQQHIAKQDLVTGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKSPAWSPYL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ARFP1_RAT
Sequence: MAEESPKNSAAEIPVTSNGEVGDAHEHGYNRDLKHSLPSGLGLSETQITSHGFDSTKEGVTEAGASQGSSAPPLPCVLSPSRVAASQLTQHAGGQRTHTKGGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQKQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYENARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQIHKEKYDKMRSDVSVKLKFLEENKVKVLRNQLALFHSAVAAYFAGNQKQLEQTLKQFHVKLKTPGVDAPSWLEEQ
What is the function of this protein?
Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network.  Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold.  Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs.  In turn, ARFs induce fission.  Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
What are the official names of this protein?
Arfaptin-1, ADP-ribosylation factor-interacting protein 1.
What are the subcellular locations of this protein?
Golgi apparatus. Golgi apparatus, trans-Golgi network membrane.
Protein: GLMU_PROMM
Sequence: MLAVAILAAGKGTRMKSCLPKVLQPLAGSTLVERVLTSCSGLQPQRRLLIVGHQAQEVQQQLTDWQGLEFVVQQPQNGTGHAVQQVLPVLEGFDGELLVLNGDVPLLRPSTIEHLVNEHRSSGADVTLLTARLADPTGYGRVFSDQQGRVSSIVEHRDCSDEQRHNNLTNAGIYCFNWKKLAAVLPQLCSDNDQGELYLTDTVALLPIAMHVEVADPDEVNGINDRCQLANCEALLQERLRNYWMKEGVTFTDPASCTLSEDCQFGRDVVIEPQTHLRGCCNIGDGCQLGPGSLIENAELGHGVSVLHSVVCDAKVGNEVAIGPFSHLRPGAGIADQCRIGNFVEIKKSQIGEGSKVNHLSYIGDAQLGRHVNVGAGTITANYDGVRKHLTVVGDNSKTGANSVLVAPIVLGSDVTVGAGSTLTKDVPNGALALGRSKQLIKNGWQ
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRTC_ASPCI
Sequence: MLFAKAFQSATVAGAVILAALVDVAHSTPLDDPGQCGLEAVAQCCTSLRESAVGDKVFAYGDIEYFRAKRSYYSVTTSLNSACIVLPESAEDVSTVLTTLTQPDLAETCPFAIRSGGHSMVVGFSDIAAGVTLDLSKLNHTIYHPETETVSLGPGGRWVNVYEELRPDNVMVSGGRFSSVGVGGFLTGGGITIYSAQRGLACDDVVSFDVVLANGTLIQATNATNPDLFHTLKGGSGNLGVVTNFEVRAFPQTQIWGGYTSYNVSKTPELARTLQNFTSNIEQDPKALLVTFWTYDTLTDVNRAANAMYYTDPVEYPEAFNDYYAIENISSTVHTRSIESLVTELEDTTNWFRVLFVTLAFKNDARVIEHGANLYQEYIDTIKANVSGGDWLVIAGFQPMPTLFGTSGQENGGNIIGLENNGDKIVLLFEAFWERTQDDELFEPLADELIHNLEEYARSLEQDSDFLYLNYADGWQDPISGYGGDNIEQLRAAAEKYDPNGVFQTQVPGGFKISKVPVAEQKK
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of various drimane-type sesquiterpene esters, compounds that exhibit diverse biological activities and are widely present in eukaryotes (PubMed:34468074).  The pathway begins with the synthesis of the backbone drimenol by the terpene cyclase drtB using farnesyl pyrophosphate (FPP) as substrate (PubMed:34468074).  The cytochrome P450 monooxygenase drtD is then responsible for the hydroxylations at C-6, C-9 and C-12, as well as the oxidation of hydroxyl groups at C-6 and C-11 to a ketone and an aldehyde, respectively (PubMed:34468074).  Then, the biosynthesis can go in two directions, either the hydroxylated drimenol is further hydroxylated at C-2 and C-3 by an enzyme(s) not associated with the drt cluster, or the FAD-binding oxidoreductase drtC further oxidizes C-11 or C-12 to form the butyrolactone ring (PubMed:34468074).  DrtB, drtD and drtC are solely responsible for the formation of the different drimane structures observed during drimane sesquiterpenes biosynthesis (PubMed:34468074).  The polyketide synthase drtA synthesizes different lengths (C6 and C8) of PKS chains, which are then oxidized to varying degrees by the short-chain dehydrogenase drtF (PubMed:34468074).  Finally, these PKS chains are transferred onto drimane sesquiterpenes by the acyltransferase drtE, forming the sesquiterpene esters (PubMed:34468074).  In addition to the different fatty acyl-CoA chains produced by drtA, drtE is also able to use cinnamoyl-CoA as a substrate (PubMed:34468074).
What are the official names of this protein?
FAD-dependent monooxygenase drtC, Drimane-type sesquiterpene ester biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: DER_RUEPO
Sequence: MSLTLAIVGRPNVGKSTLFNRLVGKRLALVDDQPGVTRDLREGQARLGDLRFTVIDTAGLETATDDSLQGRMRRLTERAVDMADICLFMIDARAGVTPNDEIFADILRRRSAHVILAANKAEGAAADAGVIEAYGLGLGEPIRLSAEHGEGLNELYAVLMPLADEMEQQAEEQAPETDVDLDPEDEDGEEVAAPHAITREKPLQVAVVGRPNAGKSTLINRILGEDRLLTGPEAGITRDAISLQIDWNDTPMRIFDTAGMRKKAKVQEKLEKLSVSDGLRAVKFAEVVVVLLDAAIPFEQQDLRIADLAEREGRAVVIAVNKWDVEENKQDKLRELKESFERLLPQLRGAPLVTVSAKTGRGLERLHDAILRAHEVWNRRIPTAALNRWLIGMLEQHPPPAPQGKRIKLRYMTQAKTRPPGFVVMCSHPDKMPESYSRYLVNGLRADFDMPGTPIRLTLRGQGDKNPYKGRRKKNAGALAKHLKSRG
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: SECY_HELPJ
Sequence: MNKAIASKILITLGFLFLYRVLAYIPIPGVDLAAIKAFFDSNSNNALGLFNMFSGNAVSRLSIISLGIMPYITSSIIMELLSATFPNLAKMKKERDGMQKYMQIVRYLTILITLIQAVSVSVGLRSISGGANGAIMIDMQVFMIVSAFSMLTGTMLLMWIGEQITQRGVGNGISLIIFAGIVSGIPSAISGTFNLVNTGVINILMLIGIVLIVLATIFAIIYVELAERRIPISYARKVVMQNQNKRIMNYIPIKLNLSGVIPPIFASALLVFPSTILQQATSNKTLQAIADFLSPQGYAYNILMFLLIIFFAYFYSSIVFNSKDIADNLRRNGGYIPGLRPGEGTSSFLNAVASKLTLWGSLYLALISTVPWILVKAMGVPFYFGGTAVLIVVQVAIDTMKKIEAQIYMSKYKTLSAVGF
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RISB_SHEPW
Sequence: MNVVQGNIESKNAKIAIVVSRFNSFVVESLLDGAVDTLKRFGQVADDNITVIKVPGAVELPLAARRVAASGKFDGIISLGAVIRGGTPHFDLVAGECNKGLAQVALEYDIPVSFGVLTTDTIEQAIERSGTKAGNKGGEAALGLLEMVNVLQALEEQL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: VE1_HPV54
Sequence: MADNQGTEEEGTGCNGWFFVEAIVERKTGDIISDDEPEDVEDSGLDMVDFIDNSVSQVEGQENPQALLHAQQLQADVEAVQQLKRKYIGSPYVSPVANSEPCVEKDLSPRLGAISLGRRSAKAKRRLFDKAQPPPNGHTDVEAAVEVNTEGTDETETDQVQTVSGETTTDSLGRQQITELIHNTNIRVALFGMFKDLYGLSFMDLARPFKSDKTVCTDWVIAAFGIYHGITDGFKTLLEPHCLYGHIQWLTCRWGMVLLLLTRFKCGKNRLTVSKCLGMLLNIPETQMLIDPPKLRTPAAALYWYRQGLSNASEIFGTPPEWLARQTVIEYSLADSQFDLSKMVQWAYDHNYIDDSIIALEYAKLADIDENAAAFLGSNCQAKYVKDCGTMCRHYIRAQKMQMTMSQWIKHRCDLVEEEGEWKEIVRFLRYQHVDFISFMIALKQFLQGIPKHNCILLYGPPDTGKSNFAMSLISFLGGVVLSYVNSSSHFWLEPLADAKIAMLDDATTQCWNYMDIYMRNALDGNPMCFDRKHRAMVQTKCPPLIVTSNINASTDDRWRYLHSRVKCFCFPNRFPFDSNGNPVYDLSNKNWKSFFKRSWSRLALNDNDNEEEENGDPSNTFRCVPGKASRPI
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: NUBP2_HUMAN
Sequence: MEAAAEPGNLAGVRHIILVLSGKGGVGKSTISTELALALRHAGKKVGILDVDLCGPSIPRMLGAQGRAVHQCDRGWAPVFLDREQSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDEHMATIEALRPYQPLGALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAGVPFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKILDATPACLP
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.  Negatively regulates cilium formation and structure.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NUBP2, Nucleotide-binding protein 2, NBP 2.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Enriched at the centrosomes during mitosis. Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (By similarity). Localized at centrioles and in the nucleus at interphase (By similarity). Colocalizes with nubp-1 at prometaphase (By similarity).
Protein: XERC_STAES
Sequence: MDKIQETFLYMLKVERNFSEYTLKSYHDDLVQFNNFLEREHLQLETFEYKDARNYLAFLYSNQLKRTTVSRKISTLRTFYEFWMTQDNSIINPFVQLVHPKKEKYLPQFFYEEEMEALFQTVEHDNKKGIRDKVIIELLYATGIRVSELINIKLKDIDMNLPGVKVLGKGNKERFIPFGEFCRQSIERYLEEFQPKQLANHDYLIVNMKGDPITERGVRYVLNDVVKRTAGVNDIHPHKLRHTFATHLLNQGADLRTVQSLLGHVNLSTTGRYTHVSNQQLRKVYLNAHPRAKKGE
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPSB_STAA8
Sequence: MSDVSLKLSAKDIYEKDFEKTMARGYRREEVDAFLDDIIADYQKMADMNNEVVKLSEENHKLKKELEELRLRVATSRPQDNKSFSSNNTTTNTSSNNVDILKRISNLEKAVFGK
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.