PharMolix/UniProtQA huggingface dataset:
Protein: RUVA_SHEB9
Sequence: MIGRLRGVLVEKQAPEILIDVNGVGYELQMPLTSFYELPEVNHETMVYTHFVVREDAQLLYGFITKQERALFRLLIKTNGVGPKLALTILSGMTAGEFVGCVERDDIVTLVKLPGVGKKTAERLLVEMRDKLKSLMEASAGSEREFVLQSNYSPAPTVNSAEEDAISALISLGYKPPQASKSVSAAYKEGMDSETLIKAALKSML
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: P10_ASFM2
Sequence: MPTKAGTKSTAHKKTTTKGPSKSPKGKTHATALHQGMLYKDMVNVAKSKGIPIYQNGSRLTKSELEKKIRRSK
What is the function of this protein?
May play a role in genome packaging through direct interaction with viral DNA.  Binds to ssDNA and dsDNA with the same apparent affinity in vitro.
What are the official names of this protein?
Structural DNA-binding protein p10, p10.
What is the protein family that this protein belongs to?
Belongs to the asfivirus P10 family.
What are the subcellular locations of this protein?
Virion. Note=Found in association with the viral nucleoid.
Protein: IRAK2_HUMAN
Sequence: MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFGP
What is the function of this protein?
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
What are the official names of this protein?
Interleukin-1 receptor-associated kinase-like 2, IRAK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Protein: TAL1_LISIN
Sequence: MRFFIDTANVEEIKKANRMGFIAGVTTNPSLVAKEGRDFNEVIQEITSIVDGPISGEVVSLNAEEMIEEGRVIAKIHPNMVVKIPMTGEGLAAVKVLTEEGIKTNVTLVFSATQALLAARAGATYVSPFLGRLDDIGDDGLVLIRDIAEIFETHGIPTEIISASVRHPIHVIECAKAGADIATVPYKVFEQMLKHPLTDSGIDKFLADWEAAKK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase 1.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOA_SALPK
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPNTQVYDLGCSLGAATLSVRRNIRHEHCRIIAVDNSPAMIERCRRHIDAYKAPTPVEVVEGDIRDITIENASMVVLNFTLQFLEPAERQALLDKIYLGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLRQAGFEHSELWFQCFNFGSLVALKAGVAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: GRGD_PENSQ
Sequence: MASEKPQESVYYLKPGDEERARLNNQHRVLVHIIENELLHAPIDPSTIVKIADVGTGTGIWLDALAAHLDPIPTAIGQPRQYDGLDMSPAHFPAFHPENFHYDVYNILQPVPEGLKGKYDLVHVRLLVSALSKGDVNTAVDNLAQLLRPGGWIQWDELDGESWAGRVPSAHVREMNELVRKHMETKGMELDVPAAFVKAAEAHPRLQNVSERIFNTIKSGPELKDDVNSVYLWSCTTSTKMILQASGTPGAEEEFKRLSEGAKADIERDGIFWDSDEHVLLAQKK
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of gregatin A, a fungal polyketide featuring an alkylated furanone core (PubMed:32275405).  The PKS grgA synthesizes C11 and C4 polyketide chains in the presence and absence of the trans-enoyl reductase grgB, respectively (PubMed:32275405).  The polyketide transferase grgF is then responsible for the fusion of the two carbon chains to produce the furanone skeleton of gregatin A (PubMed:32275405).  Next, the cytochrome P450 monooxygenase grgG accepts performs the oxidative cyclization to furnish the gregatin scaffold and leads to the formation of desmethylgregatin A (PubMed:32275405).  Finally, the O-methyltransferase grgD methylates the carboxyl group of desmethylgregatin A to provide gregatin A (PubMed:32275405).
What are the official names of this protein?
Methyltransferase grgD, Gregatin A biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Protein: PDXB_SALTI
Sequence: MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDLNVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_XANAC
Sequence: MTIKTLALQCRDAAQVVSQLSAQAKHALLEAMAAALETDAAAILAANARDLEAARAKGTGSAMLDRLALDDKRMAGIAAALREVAQLPDPVGQITRQEVRPNGIRVQKMRVPLGVIAMIYEARPNVTADAAALCIKAGNGVILRGGSEAIHSNTAIARALQGALREANVPEAALTLVEDLRRETMLELLQLNDIVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLFVDASADLALALRLLIDGKATRPAACNSLETLLVHADIAERFLPLAAQALRERKVELRGDAATRAVLPEIAPASDDDYAAEFLDLILAIRVVPDLDTALAHIRQHGSDHTEVIATQDADNAERFVQALRSAVVMVNASSRFSDGGELGLGAEIGISTTRLHSYGPMGLEALTVERFVVRGEGQVRH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_WOLPP
Sequence: MKGLYIKTYGCQMNVYDSILMENIVKPLGFNVVSDAEQADLVILNTCHIREKAAEKLYSELGRIHSSQKNKEMTIVVAGCVAQAEGEEVFRRAPFVDIVVGPQSIPALPELIVKASRSKGHVINTDFPEVAKFDKLPDECYGNSQGSSAFLAIQEGCDKFCTFCVVPYTRGAEYSRPVNEIFREALNLVKNGAKEITLLGQNVNAYHGECEGEVWDLGKLISHIAKIEKLERIRYTTSHPRDMHESLYLVHAEESKLMPFVHLPVQSGSNKILHAMNRKHTAEEYLGIIDRLRKLKPEIEFSSDFIVGFPGETEKDFEETMKLVEKVKYAQAYSFKYSPRPGTPGAERKDQVPEEVKTERLLRLQELISKQQLEFNQSMIGKTIPVLFSDKKGKHQNQIIGKSPYMQSVCVDDPDDKYKDKIVNVRILEARQNSLLGCAA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_SHIB3
Sequence: MSTDNKQSLPAITLAAIGVVYGDIGTSPLYTLRECLSGQFGFGVERDAVFGFLSLIFWLLIFVVSIKYLTFVMRADNAGEGGILTLMSLAGRNTSARTTSMLVIMGLIGGSFFYGEVVITPAISVMSAIEGLEIVAPQLDTWIVPLSIIVLTLLFMIQKHGTAMVGKLFAPIMLTWFLILAGLGLRSIIANPEVLHALNPMWAVHFFLEYKTVSFIALGAVVLSITGVEALYADMGHFGKFPIRLAWFTVVLPSLTLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLIIAALATVIASQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPFVNWMLYVAVVIVIVSFEHSSNLAAAYGIAVTGTMVLTSILSTTVARQNWHWNKYFVALILIAFLCVDIPLFTANLDKLLSGGWLPLSLGTVMFIVMTTWKSERFRLLRRMHEHGNSLEAMIASLEKSPPVRVPGTAVYMSRAINVIPFALMHNLKHNKVLHERVILLTLRTEDAPYVHNVRRVQIEQLSLTFWRVVASYGWRETPNVEEVFHRCGLEGLSCRMMETSFFMSHESLILGKRPWYLRLRGKLYLLLQRNALRAPDQFEIPPNRVIELGTQVEI
What is the function of this protein?
Responsible for the low-affinity transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Low affinity potassium transport system protein Kup, Kup system potassium uptake protein.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MATP_SHIDS
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYIEASAAQEAVDVLLSLENEPVLVNGWIDKHMNPELVNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFIVWQRLAGLAQRRGKTLSETIVQLIEDAENKEKYANKMSSLKQDLQALLGKE
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP2_BACCZ
Sequence: MEQFYYILKYLILGLFQGLTEPIPISSSGHLVLAQHLLGLKIEGFSFELLVNSASLLAVLLIYRNDLIRLTKNGLSYIFTRAEDAKSDFFFIIYLVIATIPAGVIGVLFKDYIDQYLKGVKMVGISLLITAVGLWIIRNLRGRKNDGDLSMKDAIIVGLAQACALIPGISRSGATIVAAMLLGMKQETALRFSFLLYIPVSLGGLLLSITDIAKDPNLDTLFVPYIVAFIATFIMTYISLKWFMNIMAKGNLKYFSFYCIIVGVLTLIFL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NREB_STAAR
Sequence: MINEDSIQLEALLKKYYEHSIEKIVFADDSGKIIAMNDAAKDILSEEDNYSAVANAICHRCEGYTNAYDVQSCKDCFLESMQVQATNFQVFMKTKDQKVMPFTATYQLIDQDRGIHAFTLQNVSSQIEQQEKLHQQRMMRKTISAQENERKRISRELHDSVIQEMLNVDVQLRLLKYQEDTAKLLEDAENIEYIVAKLIDDIRNMSVELRPASLDDLGLEAAFKSYFKQFEENYGVKIIYTSNIKNTRFDSDIETVVYRVVQEAILNALKYADVNEINVGIRQTGRHLVAEVIDAGNGFDPSSKPKGSGLGLYGMNERAELVSGSVNIETKIGEGTNVTLNIPI
What is the function of this protein?
Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen.  NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC.  NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT (By similarity).
What are the official names of this protein?
Oxygen sensor histidine kinase NreB, Nitrogen regulation protein B.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTAA_BRUSU
Sequence: MAATSAQHIGLQGHGTSRNDRDRRLVRYWLYAVFAVLIAIVMVGGATRMTGSGLSITEWKPIHGVIPPLNHAEWVEEFEKYQQIPQYQQINKGMSLAEFQYIFWWEWAHRLLARFVGFLVAVPLGFFWLTGRLKGGLKYRMLGLLALGGLQGAIGWWMVASGLSELTSVSQYRLAIHLTTACVIITAVFYIARGLVTYSERPAERSIQRFAGWIVFAVLVQIYLGGLVAGLHAGLTYNTWPLMDGAIIPSDLFTQAPWWRNLFENPKTVQFVHRMFAYTVLLLAILHAVQVWKNAPGTTHARRTIVLVGLVFIQAMIGIATLLMSAPLHLGLTHQFFALVVLAFAVAHWRATKGAYAA
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HV383_HUMAN
Sequence: MQFVLSWVFLVAILKGVQCEVQLVESRGVLVQPGGSLRLSCAASGFTVSSNEMSWVRQAPGKGLEWVSSISGGSTYYADSRKGRFTISRDNSKNTLHLQMNSLRAEDTAVYYCKK
What is the function of this protein?
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447).  Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170, PubMed:22158414, PubMed:24600447).
What are the official names of this protein?
Probable non-functional immunoglobulin heavy variable 3-38-3.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: PAX8_HUMAN
Sequence: MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL
What is the function of this protein?
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
What are the official names of this protein?
Paired box protein Pax-8.
What are the subcellular locations of this protein?
Nucleus.
Protein: P5CS_ACTDE
Sequence: MDAVDSTRAFVKGVKRVIIKVGTAVVTRADGRLALGRLGALCEQIHELNSQGFEVILVTSGAVGVGRQRLRYRKLVNSSFADLQKPQIELDGKACAAVGQNGLLALYDTLFSQLDVTSAQLLVTDNDFRDPEFRKQLTETVESLLNLKVIPIFNENDAVSTRKAPYEDASGIFWDNDSLAALLALELKADLLVLLSDVEGLYSGPPSDPQSKLIHTYIKEMFEGLITFGDKSRVGRGGMTAKVKAAVYAAHAGIPVVITSGYATNNIIKVLQGERIGTLFHRDAQKWAPVGDVGARDMAVAARESSRRLQAMSPQDRSKILLDVADALEANEKLIRIENEADLAAAQQAGYEKSLISRLALKSGKISSLAKSIRVLANMEEPIGHVLKRTEITDGLVLEKTSSPLGVLLIIFESRPDALVQIASLAIRSGNGLVLKGGKEAKRSNAILHKVITSAIPENVGPRLIGLVTSREEIPDLLKLDDVIDLVIPRGSNKLVSQIKESTKIPVLGHADGICHVYVDKSANMDMAKKVVLDAKTDYPAACNAMETLLVHKDLVQNGCLDELIVELQIKGVVIHGGPRASSLLHIPEARSLHHEYSSLACTIEIVDDVYAAIDHIHRHGSAHTDSIITEDHEVAEIFLRQVDSSSVLHNASTRFSDGARFGLGAEVGISTSRIHARGPVGVEGLLTTRWIARGSGQVVDGDKGIVYTHKDLTSHA
What is the function of this protein?
P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants.
What are the official names of this protein?
Delta-1-pyrroline-5-carboxylate synthase, P5CS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
Protein: Y3671_MYCTU
Sequence: MTPSQWLDIAVLAVAFIAAISGWRAGALGSMLSFGGVLLGATAGVLLAPHIVSQISAPRAKLFAALFLILALVVVGEVAGVVLGRAVRGAIRNRPIRLIDSVIGVGVQLVVVLTAAWLLAMPLTQSKEQPELAAAVKGSRVLARVNEAAPTWLKTVPKRLSALLNTSGLPAVLEPFSRTPVIPVASPDPALVNNPVVAATEPSVVKIRSLAPRCQKVLEGTGFVISPDRVMTNAHVVAGSNNVTVYAGDKPFEATVVSYDPSVDVAILAVPHLPPPPLVFAAEPAKTGADVVVLGYPGGGNFTATPARIREAIRLSGPDIYGDPEPVTRDVYTIRADVEQGDSGGPLIDLNGQVLGVVFGAAIDDAETGFVLTAGEVAGQLAKIGATQPVGTGACVS
What is the function of this protein?
Required for M. tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence.  It protects M. tuberculosis against phagolysosomal concentrations of acid and maintains its intrabacterial pH when phagocytosed by IFN-gamma-activated macrophages.
What are the official names of this protein?
Serine protease Rv3671c.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RBL1_CERSP
Sequence: MDTKTTEIKGKERYKAGVLKYAQMGYWDGDYVPKDTDVLALFRITPQEGVDPVEAAAAVAGESSTATWTVVWTDRLTACDSYRAKAYRVEPVPGTPGQYFCYVAYDLILFEEGSIANLTASIIGNVFSFKPLKAARLEDMRFPVAYVKTYKGPPTGIVGERERLDKFGKPLLGATTKPKLGLSGKNYGRVVYEGLKGGLDFMKDDENINSQPFMHWRDRFLYVMEAVNLASAQTGEVKGHYLNITAGTMEEMYRRAEFAKSLGSVIVMVDLIIGYTAIQSISEWCRQNDMILHMHRAGHGTYTRQKNHGISFRVIAKWLRLAGVDHLHCGTAVGKLEGDPLTVQGYYNVCREPFNTVDLPRGIFFEQDWADLRKVMPVASGGIHAGQMHQLLSLFGDDVVLQFGGGTIGHPMGIQAGATANRVALEAMVLARNEGRNIDVEGPEILRAAAKWCKPLEAALDTWGNITFNYTSTDTSDFVPTASVAM
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: GFI1H_CAEEL
Sequence: MSTEHVSNVYSVESLLSNVEKSSVSPTESIEDRNEFMITEDVMSSWQRMAATISLQQKLLMMQQTMPRPPPVNILGNFPFGFLNAPMFWQQYLRSMAMGIIPQNPESPSASVWNRTPTPPVEIKPFHCQKCTKLFSTIAALEQHQQVHVSDKQFECKQCGKTFKRSSTLSTHLLIHSDTRPYPCEYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCGKAFSQSSNLITHTRKHTGFKPFACDVCGRTFQRKVDRRRHRESHHPGHPEECVSASQISSDLSPKGYMTPPTSNGYLDSSDEFLNVFRLPAELLAIKAEMGEEMEEADDEEEKVLNLSVS
What is the function of this protein?
Transcription factor (PubMed:26096732).  Plays a role in the determination of neuroblast cell fate and neuronal differentiation (PubMed:11923211, PubMed:26096732).  Negatively modulates expression of several components of dense-core vesicles (DCVs), thereby, in a DCV membrane protein ida-1-dependent manner, regulating neurosecretion (PubMed:19343207).  Negatively modulates the transcription of its own gene, the mechanosensory gene mec-3, and also other touch neuron-specific genes in the BDU neurons; required for coordinated movement (PubMed:9169852, PubMed:8770591, PubMed:26096732).  Required to determine the identity of BDU sensory neurons in concert with transcription factor unc-86, regulating expression of a number of genes, including transcription factors ceh-14 and ahr-1, neuropeptides flp-10, nlp-1 and nlp-15, and tyramine receptor-encoding ser-2 (PubMed:26096732).  Acts in concert with non-canonical WNT signaling to negatively modulate transcription of mec-3 gene in BDU neurons (PubMed:26096732).  May act in concert with transcription factor unc-3 in motor neuron fate determination (PubMed:18817768).  May play a role programmed cell death (PubMed:11923211).
What are the official names of this protein?
Zinc finger protein GFI1 homolog pag-3, Pattern of reporter gene expression abnormal protein 3, Transcription factor pag-3.
Protein: KTHY_BACAN
Sequence: MKGLFVTIEGPEGSGKTTLIQSLLPYFEQKEQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVEKVMPALNEDYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIAKDAGREVNRLDMEDISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVIQVIEDKLL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SYN_LIMRJ
Sequence: METITISEVPKHVGETVKIGVWLTDKRSSGKIAFLQLRDGTGFFQGIIRKNDVSEEKFDSAKHDLHQETSFWVTGEIAEDKRSKFGYEIHIKDFDIVGESEDYPIGNKEHGIDFLLDNRHLWLRSRKPWALMRIRSRVKLATMEFFEKHGFTQFDAPELTGSAPEGTTELFETDYFDRSAFLSQSGQLYAEAGAMALGRVYTMGPTFRAEKSKTRRHLMEFWMIEPEMAWMHQDESLKIQEQYIAYLVQDLIDHCARELEMVGRSVESLKPFTELPYPRITYKEAIEILQKGGFDVEYGADFGSPEETYLADQFQKPVFILNYPKEIKAFYMPEDPEDSRQVICADLLAPEGYGEIIGGSERSYDYEYITNKLEENGLSKEDYGWYDDLRKYGSIPHSGFGMGLERFLAWITLQDHIRETIPFPRMLNRLNP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMCAL_STRPN
Sequence: MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAIVDKWTRTQMALENGADLVVELPFLVSVQAADFFGQGAMDILDRLGIDSLVFGTEEVRDYQKIADLYTEKGAEMEKFVENLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYAKAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQASKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVELVTTKRYTKARVRRLLTYILMQARESDLPEAIHVLGFTEKGRQHLKSLKGQVSLVSRIGKEPWDAMTQKADQIYQLGKPSIAEQNFGRVPIRIETN
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_BRASB
Sequence: MARVTVEDCIDKVDNRFDLVLLAAHRARMISSGSQLTIDRDNDKNPVVALREIADSTISPEDLKEELVHSLQKFVEVDEPEPDTVPLIGSAGASVDADDTEVAVERMTEEELLKGLEGLAPPEEQPEEDE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.