PharMolix/UniProtQA huggingface dataset:
Protein: SCO2_HUMAN
Sequence: MLLLTRSPTAWHRLSQLKPRVLPGTLGGQALHLRSWLLSRQGPAETGGQGQPQGPGLRTRLLITGLFGAGLGGAWLALRAEKERLQQQKRTEALRQAAVGQGDFHLLDHRGRARCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPERDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDYIVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVLS
What is the function of this protein?
Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2).  Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:17189203).  Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 (PubMed:19336478).
What are the official names of this protein?
Protein SCO2 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SCO1/2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: CDTB_ECOLX
Sequence: MKKYIISLIVFLSFYAQADLTDFRVATWNLQGASATTESKWNINVRQLISGENAVDILAVQEAGSPPSTAVDTGTLIPSPGIPVRELIWNLSTNSRPQQVYIYFSAVDALGGRVNLALVSNRRADEVFVLSPVRQGGRPLLGIRIGNDAFFTAHAIAMRNNDAPALVEEVYNFFRDSRDPVHQALNWMILGDFNREPADLEMNLTVPVRRASEIISPAAATQTSQRTLDYAVAGNSVAFRPSPLQAGIVYGARRTQISSDHFPVGVSRR
What is the function of this protein?
Part of the tripartite complex that is required for the CDT activity.  CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells.  This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.
What are the official names of this protein?
Cytolethal distending toxin subunit B, CDT B, Deoxyribonuclease CdtB.
What are the subcellular locations of this protein?
Secreted. Note=Localized to the nucleus of the infected cells.
Protein: E1A_ADE07
Sequence: MRHLRFLPQEIISSETGIEILEFVVNTLMGDDPEPPVQPFDPPTLHDLYDLEVDGPEDPNEGAVNGFFTDSMLLAADEGLDINPPPETLVTPGVVVESGRGGKKLPDLGAAEMDLRCYEEGFPPSDDEDGETEQSIHTAVNEGVKAASDVFKLDCPELPGHGCKSCEFHRNNTGMKELLCSLCYMRMHCHFIYSPVSDDESPSPDSTTSPPEIQAPAPANVCKPIPVKPKPGKRPAVDKLEDLLEGGDGPLDLSTRKLPRQ
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E1A protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome.  Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for degradation by MDM2-mediated ubiquitination anymore.  This increase in TP53, in turn, would arrest the cell proliferation and direct its death but this effect is counteracted by the viral protein E1B-55K.  Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection.  Interaction with RBX1 and CUL1 inhibits ubiquitination of the proteins targeted by SCF(FBXW7) ubiquitin ligase complex, and may be linked to unregulated host cell proliferation.  The tumorigenesis-restraining activity of E1A may be related to the disruption of the host CtBP-CtIP complex through the CtBP binding motif.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).  Promotes the sumoylation of host ZBED1/hDREF with SUMO1 (By similarity).
What are the official names of this protein?
Early E1A protein, Early E1A 28 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1A protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: DNAK_PORUM
Sequence: MGKVVGIDLGTTNSVIAVMEGGKPTVIPNAEGFRTTASVVAYTKSGDKLVGQIARQAVINPENTFYSVKRFIGRKQNEISQEIRQTSYNVKTSGSSIKIECPALNKDFAPEEISAQVLRKLVEDASTYLGETVTQAVITVPAYFNDSQRQATKDAGKIAGLDVLRIINEPTAASLSYGLDKQNNETILVFDLGGGTFDVSILEVGDGVFEVLSTSGDTHLGGDDFDQQIVEWLIKDFKQSEGIDLGKDRQALQRLTEASEKAKIELSNLTQTEINLPFITATQDGPKHLEKTVTRAKFEELCSRLIDKCSIPVNNALKDAKLEASSIDEVVLVGGSTRIPAIQQMVKRLIGKDPNQSVNPDEVVAIGAAVQAGVLAGEVKDILLLDVTPLSLGVETLGGVMTKIIPRNTTIPTKKSEVFSTAVDNQPNVEIQVLQGERELTKDNKSLGTFRLDGIMPAPRGVPQIEVTFDIDANGILSVKAKEKATGKEQSITISGASTLPKDDVERMVKEAEENFDVDQKRRKNIDIRNQAESLCYQSEKQVKEFEDKIDEELKNRITNLISELRSNLEKEELDSIEANSEKLQNALMEIGKNATSAEKDTQNASNDDTVIDTDFSEAK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein dnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLRA2_DANRE
Sequence: MTRPSVKLLTTLLACLMEMLNFRVSSGKDPDLLSSSSSSMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQKWNDPRLAYSEYPDSSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRIFKDGTVLYSIRLTLILSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLDKGPVQVADGLTLPQFLIRDEKDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAGVNFVSRQQKEFLRLKRRQRRTQKEEDLQDGRLHFSSYNTTTCVKDGAVVKNTQVNQIQQPSILKNTETNRKKFVDRAKRIDTISRAAFPLAFLIFNVFYWITYKIIRHESARKD
What is the function of this protein?
Glycine receptors are ligand-gated chloride channels.  Channel opening is triggered by extracellular glycine.  Channel opening is also triggered by taurine and beta-alanine.  Plays a role in synaptic plasticity.  Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability.  Plays a role in cellular responses to ethanol.
What are the official names of this protein?
Glycine receptor subunit alpha-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Protein: RMLD_ECOLI
Sequence: MNILLFGKTGQVGWELQRALAPLGNLIAFDVHSTDYCGDFSNPEGVAETVRSIRPDIIVNAAAHTAVDKAESEPEFAQLINATSVEAIAKAANEVGAWVIHYSTDYVFPGNGDMPWLETDATAPLNVYGETKLAGEKALQEYCAKHLIFRTSWVYAGKGNNFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRVALNKPDVAGLYHLVASGTTTWYDYAALVFEEARKAGIPLALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFALVLPDWQVGVKRMLNELFTTTAI
What is the function of this protein?
Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS) (Probable).  Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose (By similarity).  RmlD uses NADH and NADPH nearly equally well (By similarity).
What are the official names of this protein?
dTDP-4-dehydrorhamnose reductase, dTDP-4-keto-L-rhamnose reductase, dTDP-6-deoxy-L-lyxo-4-hexulose reductase, dTDP-6-deoxy-L-mannose dehydrogenase, dTDP-L-rhamnose synthase.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose reductase family.
Protein: CYSP3_DICDI
Sequence: MRLSITLIFTLIVLSISFISAGNVFSHKQYQDSFIDWMRSNNKAYTHKEFMPRYEEFKKNMDYVHNWNSKGSKTVLGLNQHADLSNEEYRLNYLGTRAHIKLNGYHKRNLGLRLNRPQFKQPLNVDWREKDAVTPVKDQGQCGSCYSFSTTGSVEGVTAIKTGKLVSLSEQNILDCSSSFGNEGCNGGLMTNAFEYIIKNNGLNSEEQYPYEMKVNDECKFQEGSVAAKITSYKEIEAGDENDLQNALLLNPVSVAIDASHNSFQLYTAGVYYEPACSSEDLDHGVLAVGMGTDNGEDYYIVKNSWGPSWGLNGYIHMARNKDNNCGISTMASYPIA
What are the official names of this protein?
Cysteine proteinase 3, Cysteine proteinase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: ILVD_PROMT
Sequence: MLRSNAITQGIQRSPNRAMLRAVGFDDNDFNKPIIGIANGHSTITPCNMGLMDLANRAESALKEAGAMPQTFGTITVSDGISMGTEGMKYSLVSREVIADSIETACNAQSMDGVLAIGGCDKNMPGAMLSMARMNIPSIFVYGGTIKPGKLDGCDLTVVSSFEAVGQLASGKIDKDRLIAVEKNAIPGPGSCGGMFTANTMSAAIETMGFSLPFSSTMAAVDDEKAESAAESAQVLVNAVKNNIRPLDLLTKEAFENAISVIMAVGGSTNSVLHLLAIARTAGVDLTIDDFERIRQTVPVICDLKPSGKYVTVDLHKAGGIPQVMKLLLDAGMLHGECKTIEGKTIKEVLRDIPSKPKENQDVIRQISNPIYKKGHLAILKGNLASEGSVAKISGVKTPVLTGPARVFESEEECLTAILDNKVKAGDVVVVRYEGPVGGPGMREMLSPTSAIVGQGLGEKVALITDGRFSGGSYGLVVGHVAPEAAVGGTIGLVEEGDSITVDANKLLIQLNVEERELARRKQKWEKPKPRYKTGILGKYSRLVSSSSQGATTDQI
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RIMO_PELPD
Sequence: MESTEKQKVSMVSLGCSKNLVDAEVMLGLLARQEYEITTDEREADIIIVNTCSFIKEAKQESIDAILDLAERKNDGRCHTLIVSGCLPQRYQEELARELPEVDIFIGTGDYPRIAEILAEKSGTDEQLCYIGDPDFVFDETLPRLNSSPAWFSYLKIGEGCSNRCSYCIIPKLRGPYRSRPLEALVAEAEQLASRGVKELNIISQDITRYGSDMEDGTTLETLLRRLVQIDGIQWIRLLYAYPDGISDALIALIRDEPKICKYLDIPLQHISDPVLKLMRRRSNEQQIRELLAKLRREIPTLALRTSLIVGFPGETMEDFTSLMQFVEQARFDRLGVFCYSREEGTPAATMPDQVSERVKRERHRKLMRIQARLSFKRNRELIGTTEQVIVEGYSEETELLLKGRSSRQAPDIDGQVYITAGTADVGDIVALRITDSSDYDLIGEIQERT
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_SULSY
Sequence: MSTIIDIIGREVLDSRGNPTVEATAVLESGVVASAIVPSGASTGANEALELRDGDKKRFLGKGVLKAVENINTKIADLLIGEESEDQVRIDRLMIEADGTENKSNLGANAILAVSLAVARATAIEKEMPLYRYLGGVNAKVLPVPLMNVINGGAHADNELDFQEFMIVPVCGGSFKEALRAGVETFHVLKSVLKEKGYSTNVGDEGGFAPALRETKEALDMLMLAIDKAGYTPGEDIFIALDAASSEFYKDGKYLFEKRELTSDDMIILYEEIVGTYPVISIEDGLAENDWEGWKNLTQALGNKVQLVGDDLFTTNPKIIKEGIKNNIANSVLIKLNQIGTLTETLDAIEMARINNYTAIISHRSGESEDTFIADLAVATNAGQIKTGSASRTDRVAKYNQLIRIEEELGENAIFKGKQAFKKFQFEE
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ALLA_ECOSE
Sequence: MKLQVLPLSQEAFSAYGDVIETQQRDFFHINNGLVERYHDLALVEILEQDRTLISINRAQPANLPLTIHELERHPLGTQAFIPMKGEVFVVVVALGDDKPDLSTLRAFITNGEQGVNYHRNVWHHPLFAWQRVTDFLTIDRGGSDNCDVESIPEQELCFA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the anaerobic utilization of allantoin as sole nitrogen source.  Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: RIMP_LACDA
Sequence: MPKNLTPILEAIEPVIIGHDCELVDLEYVKEKSQDYLRIYVDKQPNGIDIETIAELSELVGEKLDSMQPDPLPDPYILELSSPGLERPIKKEQDWEKAKGQYIHVGLYQKLEGEKVFEGHLLDLDDQEIKLEIKIKTRRKQLTIPRKQIASARFAIEF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_SERP5
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINLDEEVQRLREKSVELTRKIFSDLGAWQVAQLARHPRRPYTLDYIKHIFTDFEELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMASRFKLPLITFIDTPGAYPGVGAEERGQSEAIAHNLREMSRLNIPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGITAPRLKELKLIDSVIPEPLGSAHRDVPAMAATLKAQLLADLKDLDGLNNEELRNRRYQRLMNYGYC
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AKA12_HUMAN
Sequence: MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES
What is the function of this protein?
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
What are the official names of this protein?
A-kinase anchor protein 12, AKAP-12, A-kinase anchor protein 250 kDa, AKAP 250, Gravin, Myasthenia gravis autoantigen.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Lipid-anchor. Note=May be part of the cortical cytoskeleton.
Protein: SYK_XANCB
Sequence: MTEQTPTPQLPADENSLIAERRAKLGALRGQGIAYPNDFVRTHFAGDLQAEFAEAETWTAEALEAADRSVKLAGRLMAKRVMGKASFAQIQDESGRVQLFLQGNVLGDAYTAFKGWDVGDIVAVEGGLTRTKTGELSVKASALRLLTKSLRPLPDKWHGLSDVEQRYRQRYVDLIVTPEAREVFIKRSKIIRAIRAWLDARRFLEVETPMMHYIPGGATAKPFTTHHNALDLDLYLRVAPELYLKRLVVGGLERVYEINRNFRNEGVSTRHNPEFTMLELYEAYATYHEIMDLTEQVIRDTAQGVLGTTQVSWDGADIDLAPAFRRWRMDEAVRHHNPEISAADCTDRAALLRHCERLKIKVKPSYGWGKLLLEIFEATVEHTLVQPTFITDHPVEVSPLARASDTEPGYTDRFELFINGKELANGFSELNDPEDQAARFQAQVQAKDGGDDEAMHYDADYIRALEYGMAPTGGLGIGIDRLVMLLTGSTSIRDVLLFPYMRPEA
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROQ_SALPC
Sequence: MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVERVGGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELEEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAAAAGEKEDAPRRERKPRPVARRKEGAERKPRADKPTTKAPRAPREEKHTPVSDISVLTVGQSLKVKAGNNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANFY1_MOUSE
Sequence: MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCTLLAAQANKENSNESFISRLLAIVAGLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTEEIDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSLSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNETDHNGDLALDLALSRRLESIATTLVSHKADVDMVDKNGWSLLHKGIQRGDLFASTFLIKNGALVNAATAGAQETPLHLVALYSPKKYSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHLSIMARNDCVFSQLLQCKQLDLELKDHEGSTALWLAVQYITVSSDQSVNPFEDLPVVNGTSFDENSFAARLIQRGSNTDAPDVMTGNCLLQRAAGAGNEAAALFLATSGAHANHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPVPKESPVLMSSADSIYLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGASINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIKHQLPLVVDAICTRGADMSVPDEKGNPPLWLALASNLEDIASTLVRHGCDATCWGPGPSGCLQTLLHRAVDENNESTACFLIRSGCDVNSPRQPGTNGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPVHVAISNQHSVIIQLLISHPNIELSVRDRQGLTPFACAMTYKNNKAAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVQANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRALLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPEYPLDKPDAEGNTVLLLAYMKGNANLCRAIVRSGVRLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSNCYECTAKFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFDVLTLGGVS
What is the function of this protein?
Proposed effector of Rab5.  Binds to phosphatidylinositol 3-phosphate (PI(3)P).  Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes.  Required for correct endosomal localization.  Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB.  Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner.  Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity).  Involved in macropinocytosis; the function is dependent on Rab5-GTP.
What are the official names of this protein?
Rabankyrin-5, Rank-5, Ankyrin repeat and FYVE domain-containing protein 1, Ankyrin repeats hooked to a zinc finger motif.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein. Cytoplasmic vesicle. Note=Also associated with endosomal membranes. Localizes to macropinosomes. In kidney proximal tubule cells localizes to vesicle-like structures underneath the apical brush border.
Protein: RL37_AERPE
Sequence: MGKGTPSMGKHGRSKTHIVCRRCGRRSYNVAKGYCAACGFGRSRRMRRYSWQNKKWNRVRVV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L37e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL37 family.
Protein: WPP3_ARATH
Sequence: MAETADTINTTVSTPQPQLESRSDETSCLQKHRSDATSEVTKEEKSGGILFSVWPPCQKSRDYVVNSMIKTLSTDSILSYKYGTIKPEEASAVAKSIEEKAYDIASRFVSSDGIKNLEVYGIETSERMIESAEVRFKANGSMELLLNQTIKMMQLLI
What is the function of this protein?
Regulates the mitotic activity in roots.
What are the official names of this protein?
WPP domain-containing protein 3, MFP1 attachment factor 3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PSBL_EMIHU
Sequence: MSAPNPNKQPVELNRTSLYWGLLLMFVLAVLFSSYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PTPRD_MOUSE
Sequence: MVPVARPLSLLLTFFLCACAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIATTRYSVAGLSPYSDYEFRVVAVNNIGRGPASEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIASYELVYRDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSLKYAAVDGEDFKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTDEDVPSGPPRKVEVEAVNATAVKVSWRSPVPNKQHGQIRGYQVHYVKMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISVPEEIPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGVITKYTLLYRDINVPLLPMEHLIVPADTSMTLTGLKSDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPDVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMDHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESESRKSSLPNSKEVPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGSFDHYAT
What is the function of this protein?
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590).  Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451).
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase delta, Protein-tyrosine phosphatase delta, R-PTP-delta.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.