PharMolix/UniProtQA huggingface dataset:
Protein: DPNP_ENTH1
Sequence: MSFDKELALALEIVQVSCKITTSVAEHTLTDQTQIKNDKSPVTVGDYSVQAYVNKKIHETFPEDQIVAEEDTKTIPEDIFAKVCKHVQIYSDMKDDEIRKSIDLGNSTGGKGRHWVLDPIDGTLGFLRREQYAVCLAFMIDGDIKVGVLGCPNFEGGLIVAAQKGCGAKMFSVNDIKNGKDIHVSTTPKTSDMCFCESVEVSHTDQSRSKTITERLQVTKPPVRMDSQCKYMAIASGRADVYLRLPRNLSYQEKIWDHAAGYLIVKEAGGKVTDIYGNDLDFSLGRTLCNNHGIVASNGILHEETVNVVKDVLSDLK
What is the function of this protein?
Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP (PubMed:25004978).  Is also able to hydrolyze inositol 1,4-bisphosphate but with less efficiency (PubMed:25004978).
What are the official names of this protein?
3'(2'),5'-bisphosphate nucleotidase, 3'-phosphoadenosine 5'-phosphatase-1, PAP phosphatase-1, Inositol-1,4-bisphosphate 1-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
Protein: MURC_CHRSD
Sequence: MTASSVHSPVRQNRTGLGMRRIRHIHFVGIGGAGMCGIAEVLANQGYIVSGSDLRESAVTRHLRDCDIRVYIGHVDEHAHGADVLVVSTAVDLENPEIRWAREHRIPVVRRAEMLAELMRFRHGIAVAGTHGKTTTTSLTSTLLAEGGLDPTFVIGGKLTSAGTNARLGEGDYLVAEADESDASFLHLQPMVSIVTNIDADHMATYAGDFARLKDTFLEFLHNLPFYGLAVLCLDDDNVRGLLPRVQRQFVTYGFAEDADYRLRDFVQRGGEVQFTAERPPGMAPLEIRLGMPGRHNALNALAAIAVASDAGVDDAAIQQGLLHFAGVGRRFQVHGHYPAPGGEGDVMLVDDYGHHPREVEMVIDAVRAGWPERRLVMLYQPHRYSRTRDLYEDFVRVLSGVDTLLLLDVYSAGESSIPGAEGRTLAGSIRQRGQVDPIFVESKQELPALLSRVLRPDDILITQGAGDIGGISLRLAAGQLDLNGMEL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBB1_PSE14
Sequence: MSDNTLYLRREKRFLVLLGIICLALIGGALYMQIVLGEAPCPLCILQRYALLFIAIFAFIGAAMSGRRGVTVCETLVTLSALGGIAAAGRHVWILAHPSDSCGIDVLQPIVDGLPLATLFPTGFQVSGFCTTPYPPVLGLSLAQWALAAFVLTAVLVPACIIRNRRKPY
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B 1, Disulfide oxidoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCR4_YEAST
Sequence: MNDPSLLGYPNVGPQQQQQQQQQQHAGLLGKGTPNALQQQLHMNQLTGIPPPGLMNNSDVHTSSNNNSRQLLDQLANGNANMLNMNMDNNNNNNNNNNNNNNNGGGSGVMMNASTAAVNSIGMVPTVGTPVNINVNASNPLLHPHLDDPSLLNNPIWKLQLHLAAVSAQSLGQPNIYARQNAMKKYLATQQAQQAQQQAQQQAQQQVPGPFGPGPQAAPPALQPTDFQQSHIAEASKSLVDCTKQALMEMADTLTDSKTAKKQQPTGDSTPSGTATNSAVSTPLTPKIELFANGKDEANQALLQHKKLSQYSIDEDDDIENRMVMPKDSKYDDQLWHALDLSNLQIFNISANIFKYDFLTRLYLNGNSLTELPAEIKNLSNLRVLDLSHNRLTSLPAELGSCFQLKYFYFFDNMVTTLPWEFGNLCNLQFLGVEGNPLEKQFLKILTEKSVTGLIFYLRDNRPEIPLPHERRFIEINTDGEPQREYDSLQQSTEHLATDLAKRTFTVLSYNTLCQHYATPKMYRYTPSWALSWDYRRNKLKEQILSYDSDLLCLQEVESKTFEEYWVPLLDKHGYTGIFHAKARAKTMHSKDSKKVDGCCIFFKRDQFKLITKDAMDFSGAWMKHKKFQRTEDYLNRAMNKDNVALFLKLQHIPSGDTIWAVTTHLHWDPKFNDVKTFQVGVLLDHLETLLKEETSHNFRQDIKKFPVLICGDFNSYINSAVYELINTGRVQIHQEGNGRDFGYMSEKNFSHNLALKSSYNCIGELPFTNFTPSFTDVIDYIWFSTHALRVRGLLGEVDPEYVSKFIGFPNDKFPSDHIPLLARFEFMKTNTGSKKV
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.  CCR4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.  Discovered because of its role in the control of ADH2 gene expression.  It is required for the expression of genes involved in non-fermentative growth and it mediates or is required for the action of the SPT6 and SPT10 genes.
What are the official names of this protein?
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4, Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ATP8_YEAST
Sequence: MPQLVPFYFMNQLTYGFLLMITLLILFSQFFLPMILRLYVSRLFISKL
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, ATP-associated protein 1, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: TGT_BORRA
Sequence: MFNIIKNDKNSNARLGILELPHGNVATPCFMPVGTLGVMKALKHDVLEKLGCDLMLANTYHLYLRPGIDVIKKYGNLHNFTTWNKNFLTDSGGFQVFSLSNFRKIEDEGVDFKSHIDGSRHYFTPESVFSMQETFESDIIMALDICSPYGIDYDEASLYTNITTSWARRTLCAYKNRKEGYEGLLFLITQGNFFKDLRKRSTELILELNSPGIAIGGISVGEPRDRYLEILEYNSSLIPKDKPKYVMGIGTPHYILDAIYNGIDIFDCVNPTRIARHGSLLTDNGILRINRAEFCFDTCSVERECSCTLCTRYSRGYLRHLFKSEEALGVMLASEHNIHYMFRLINKTKNAIMNDNFVKFRKLYLDKYDEGNLNE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NUOI_VEREI
Sequence: MTAVAAAPFSFKDFFKSFMLVELFKGMALTGRHAFRRKVTVQFPEEKTPLSPRFRGLHALRRYDNGEERCIACKLCEAVCPALAITIESELRADGSRRTTRYDIDLTKCIFCGFCEESCPVDSIVETHIFEYHGEKRGDLYFTKDMLLAVGDRYEAEIAAARAADAKYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYA_PYRFU
Sequence: MEFVMKTRMFEEEGWIRKTCKVCGKPFWTLDPDRETCGDPPCDEYQFIGKPGIPKKYTLDEMREKFLSFFEKHEVYPHGRVKRYPVLPRWRDDVLLVGASIMDFQPWVISGEADPPANPLTISQPSIRFTDIDNVGITGRHFTIFEMMAHHAFNYPGKHIYWIDETVELAFEFFTKELKMKPEDITFKENPWAGGGNAGPAFEVLYKGLEVATLVFMQYKKAPANADPSQVVIIKGEKYVPMETKVVDTGYGLERLVWMSQGTPTAYDAVLGYVIEPLKRMAGVEKIDERILMENSRLAGMFDIEDMGDLRYLREQVAKRVGISVEELERLIRPYELIYAIADHTKALTFMLADGVVPSNVKAGYLARLLIRKSIRHLRELGLEVPLAEIVAMHIKELSPTFPEFKEMEDIILEMIELEEKKYAETLRRGSDLVKREIAKLKKKGANEIPLEKLITFYESHGLTPEIVKEIAEKEGVKVHIPDNFYSLVAKEAEKQVEEKEEEVVDFELVKDLPDTRTLYYEDPFMKEFDAKVLKVIEDWVVLDQTAFYPEGGGQPYDTGILVVDGEEVKVTNVQKVGKVILHKVERPELFKEGTIVHGRIDWERRIQHMRHHTGTHVLMGALVRVLGKHVWQAGSQLSTDWARLDITHYKRISDEEIKEIERLANRVVMENRRVRWEWLPRTEADEKYGFRLYQGGVVPGRIIRILNIEDWDVQACGGTHLPSTGLIGPIKILRTERIQDGVERIIFACGEAAVREWQKEREIIKRTSQILRVPPEKLPETAERFFNEWKEARKEVEKLRKELAKLLVYELESKVEKVGEIEFIGEIVEGSMDDLREAANKLRKENRVVVLVNKEGHFVVAVGDKLPYTAGEFAKLITSVAGGGGGGRKELAQGKIRDIEKAKEAIEKVKGSL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMP46_CANGA
Sequence: MSMFRTLQRQPRTISLFTHDLENSRPCLSILEYLKSHTTNRFDLELSTKFPTLDQVHYMNAINPMILRAQIPHLTKIMKLKSYDPLFGSQLSDCVTKGFWNKEAPLWVDWEKKALGTDLQSIKELLEKD
What is the function of this protein?
Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.
What are the official names of this protein?
Putative redox protein FMP46, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the FMP46 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HSLU_LISIN
Sequence: MTNLTLMNQLTPKQIVEKLDQYIIGQTGAKKSVAVALRNRYRRQLMDESIRDEIIPKNILMIGPTGVGKTEIARRIAKIVRAPFSKVEATKFTEVGYVGRDVESMVRDLVEVSVRLVKEEKMQLVRVKAEKNAEKRLIKLLAPSQKKKQTTSQNPLEALFGSMNQPDEPAEEEVDQELKNKRSQIEWRLQNGELDDEIVTVEVKEQQNPMFDMMRGTGMDQMSGMQDALSGMFPAKKKKRKVTVREAKKILFEDEASKLIDSDELAAEGIHRAEQMGMIFIDEIDKIASKEGGGNAQVSREGVQRDILPIVEGSQISTKYGTVNTEYILFIAAGAFHMSKPSDLIPELQGRFPIRIELDKLTQEDFYKILTEPDNALIKQYKALLKTEGIDLIFTKEAVERIAEIAFQVNQDSDNIGARRLHTILEKLLEDLLFEAPEINMESIKVTENYVNEKLAPIMTNKDLTQFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBQ_SINSX
Sequence: MTRRIMLQGTGSDVGKSVLVAGLCRLAANQGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALAARVPSSVHMNPVLLKPQSDVGSQIVVQGKVAGQARGREYQALKPKLLGAVMESFEQISAGADLVVVEGAGSPAEINLRPGDIANMGFATRANVPVVLVGDIDRGGVIASLVGTHAILPEEDRRMVTGYLINKFRGDVTLFDDGIAAVNRYTGWPCFGVVPWLKAAARLPAEDSVVLEKLTRGEGRALKVAVPVLSRIANFDDLDPLAAEPEIDLVFVRPGSPIPVDAGLVVIPGSKSTIGDLIDFRAQGWDRDLERHVRRGGRVIGICGGYQMLGRRVTDPLGIEGGERAVEGLGLLEVETEMAPEKTVRNSRAWSLEHDVVLEGYEIHLGKTQGADCGRPSVRIDNRADGALSADGRVMGTYLHGLFTSDAYRGALLKSFGIEGGANNYRQSVDAALDDVANELEAVLDRRWLDELLRH
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: PSTB2_PSESM
Sequence: MQHERPTHGMNIPALRRRKQVLDLAEETVAIEVPGLSLFYGDKQALFDIALNIPKQKVTSFIGPSGCGKSTLLRSFNRMNDLVDGCRVEGAINLYGHNIYTKGEEVAELRRRVGMVFQKPNPFPKTIYENVVYGLRIQGINKKRVLDEAVAWALKAAALWDEVKDRLHESALGLSGGQQQRLVIARTIAVEPEVLLLDEPCSALDPISTLKVEELIYELKSKYTIVIVTHNMQQAARVSDYTAFMYMGKLVEFGDTDTLFTNPAKKQTEDYITGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 2, ABC phosphate transporter 2, Phosphate-transporting ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RZ1C_ARATH
Sequence: MAAKEGSRIFVGGLSPEVTDRDLERAFSRFGDILDCQIMLERDTGRSRGFGFITFADRRAMDESIREMHGRDFGDRVISVNRAEPKLGRDDGESHGSRGGRDSGYSIAGKGSFGGGGGGGGRVGEDECFKCGRVGHWARDCPSAGGGRGGPVGGFSSRASAYGGSDGRVDRYADRDRYVDRERYIDDRYDGAARYGARDRFDSREAYIPRDRYASDRYAAPADRFAGGDRYSRGSDRYPPGSYDKARSFERDIAPSAGSDRYGGGRAGGPIRGGGEEGRGFRSRAGAPYERPSRSGGGGAYPSSSTFDRY
What is the function of this protein?
Binds RNA and DNA sequences non-specifically.  May be involved in tolerance to cold stress.
What are the official names of this protein?
Glycine-rich RNA-binding protein RZ1C, AtRZ-1C.
What are the subcellular locations of this protein?
Nucleus.
Protein: LACB_STAAE
Sequence: MKIALGCDHIVTDTKMRVSEFLKSKGHEVIDVGTYDFTRTHYPIFGKKVGEQVVSGNADLGVCICGTGVGINNAVNKVPGVRSALVRDMTSALYAKEELNANVIGFGGRIIGELLMCDIIDAFINAEYKPTEENKKLIAKIKHLETSNADQADPHFFDEFLEKWDRGEYHD
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacB.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: UPPP2_BURCH
Sequence: MSLWFLVFLSVLQGVTELFPVSSLGHTLLVPALFGMHIDKHAPQLLPFLVALHLGTALALLWYFRARWIALIGGFFAQLGGRKNDDGHLMWALIIGTIPTGIVGLLLEKRIERVFHDLRIVAIALIVNGVLLWLGDRIQRSRAHQAPEKMTFKQAFFVGLAQIGALIPGFSRSGLTMIAGNVAGLTAEKAAEFSFLLGTPIIFAAGVLELPKLFHARDQLADALLGGVLTAIAAYLSVRFLMRYFEGRGRLASFGVYCVIAGVFCLGWFMLHPQPV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPE_STAA8
Sequence: MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPPSAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGADGALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
Putative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: FLGJ_BUCAP
Sequence: MKNDLSLFNIINYRTKFINDLKYQVKNNPKKYQLETAKEVESLFIQMLLKSMRNSLTQDNLLDSNQSRFYTEIYDQKISKEIAKRGIGLTHIILQQIQKINNNFYL
What are the official names of this protein?
Putative flagellar protein FlgJ homolog.
What is the protein family that this protein belongs to?
Belongs to the FlgJ family.
Protein: VP4_ROTHD
Sequence: MASLIYRQLLTNSYSVDLHDEIEQIGSEKTQSVTVNPGPFAQTRYAPVNWGSWEINDSTTVEPVLDGPYQPTTFKPPNDYWLLISSNTNGVVYESTNNNDFWTAVSSVEPHVSQTNRQYILFGENKQFNVENNSDKWKFFETFTGSSQGNFSNRRTLTSSNRLVGMLKYGGRVWTFHGETPRATTDSSNTADLNNISIIIHSEFYIIPRSQESKCNEYINNGLPPIQNTRNVVPLSLSSRSIQYKRAQVNEDITISKTSLWKEMQYNRDIIIRFKFGNSIIKLGGLGYKWSEISYKAANYQYSYSRDGEQVTAHTTCSVNGVNNFSYNGGSLPTDFSISRYEVIKENSYVYIDYWDDSKAFRNMVYVRSLAANLNSVKCTGGSYNFRLPVGKWPIMNGGAVSLHFAGVTLSTQFTDFVSLNSLRFRFSLTVDEPSFSIIRTRTINLYGLPAANPNNGNEYYEMSGRFSLISLVQTNDDYQTPIMNSVTVRQDLERQLNDLREEFNSLSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDLTKSMATSVMKKFRKSKLATSISEMTNSLSDAASSASRSASIRSNLSTISNWTNTSKSVSNVTDSVNDVSTQTSTISKKLRLREMITQTEGLSFDDISAAVLKTKIDMSTQIGKNTLPDIVTEASEKFIPKRSYRVLKDDEVMEINTEGKFFAYKVDTLNEIPFDINKFAELVTDSPVISAIIDFKTLKNLNDNYGITRIEAFNLIKSNPNVLRNFINQNNPIIRNRIEQLILQCKL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: RL10_RHOP2
Sequence: MERAAKKEAVESLNGLFQTTSVAVVAHYSGLTVAQMQKLRSQMKAAGASVKVSKNRLAKIALEGTDVVAIGSLLKGPTVIATSDDPVAAPKVAVEFAKANEKFVILGGSMGKTVLNVDGVKALASLPSLDELRGKLVGLLVAPATKIAQLTTAPAAKVARVVQAYASKSEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: FYV4_CANAL
Sequence: MFRTLLSSTVRSIQLKPVTSTLSTTIPSITSIPTVSYFSTSPINYKTNTSTRTKENVHDLTTFLTLIGRNSIEYKDLFEDDLNKFLSTTSAQMKNMGIDTRARRYLLRWRHKFLNDLEPLREHKLGKKRNGGERKAKTVIAKRQALERLEEKEKWAQEELEAEKRGERLF
What is the function of this protein?
Involved in telomere length regulation.
What are the official names of this protein?
Protein FYV4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UBA4_ASPCL
Sequence: MENLEQTCASLRAQIAATEAQLAGLKRDLEVAEQAAAEIKAQDVKSTGIREEGSEKKNPWPLLSEEYKRYGRQMIVPQLGLQGQLKLRSARVLIVGAGGLGCPAALYLAGAGVGTLGLVDGDTVEHSNLHRQVLHRSKNVGKFKVDSAIEYLRELNPHPTYVPYRAHLTPQEAPEIFKDYDIVLDCTDNPATRYLISDTAVLLGKPLVSASALRTEGQLIVLNNPPRPVGDKSGGPCYRCVFPKPPPATSVVSCADGGIIGPVVGTMGVLQAIEAIKVITSSPADETSASPPSLLIFSAYSTPPFRSIKIRSRRANCAVCSAEASVTVETLKTGSTDYVFFCGVAGPETLLRPEERITPLEFKKKHPGQVSHEQELGGSKEPTIIDVREQVQFDICSLDNSINIPISTILSSAASPTTSTPESLPSWLPHDIVSSSSTDPIYVVCRLGNDSQIAVRKMKELGLDQGGKRFICDIQGGLRAWREQIDPDWPEY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Also essential during biosynthesis of the molybdenum cofactor.  Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a.  Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and mocs2a.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions (By similarity).
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase uba4, Common component for nitrate reductase and xanthine dehydrogenase protein F, Ubiquitin-like protein activator 4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOCD_SALDC
Sequence: MTDLTAQDAAWSTRDHLDDPVIGELRNRFGPDAFTVQATRTGIPVVWVKREQLLEVGDFLKKLPKPYVMLFDLHGMDERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSENDLRVPTFTKLFPNANWYERETWEMFGIDIEGHPHLTRIMMPQTWEGHPLRKDYPARATEFDPFELTKAKQDLEMEALTFKPEDWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLDGEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALRNTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPVGGGVSDCYTRVMLKVEELRQSLRILQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPAQESFQMVEATKGINSYYLTSDGSTMSYRTRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RPOA_NEOYE
Sequence: MAQFQIECIESRTDGARGQYGSFVIEPLNQGQGITLGNALRRSILSDLEGTAIVAVRIAGVNHEFSTIPGVREDVLEILLNLKEVVFKSYNKESQIGRIRVQGPAIVTAGLFELSSDIEVVDPRQYIATICNNTIFEMEFKIEKNCGYRLAEKAVDELSVDFLQVDSVFMPVNKVNYKVEEVRIGSNSIKDRLIIQIWTNGSISPQEAISQGATVLTNLFCSLRNLDFKSADNYRSKEDKKISQVLIEELQLSVRAYNCLKRAQIHSIADLLDYSQEELLEIKNFGQKSAEEVIYALQKKLGISLPKEKSD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLO2_SYNS3
Sequence: MAMASTIDGIHPVAVLNDNIVWVWVRGNQAIVIDPAVAAPILDWLDRRGLQLVAVLQTHHHSDHIGGTPGLLQRWSSAEVIAAADDKERIPFQTLSVRDGDEIELLGRPVRVMDVRAHTRAHIAYWLPQGEISTSLTSVLFCGDTLFSGGCGRLFEGTPADMHRALQRLGSLPPETLVCCAHEYTEANLRWAAQQEPDDALITNRLRVVEATRRSGSLTLPSSIAEEWRSNLFLRATSSEELGRLRQHKDSWRG
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.