PharMolix/UniProtQA huggingface dataset:
Protein: RNPH_ALKEH
Sequence: MRPSGRKPDELRPVRLTRHYTRHAEGSVLVEFGDTRVLCTASVEERVPPWLRNQGRGWVTAEYGMLPRSTGTRNDREAARGKQQGRTIEIQRLIGRALRAAVDLEALGERRVVLDCDVLQADGGTRTAAITGAYVALVDACNLLRKEGRIRRSPIFGQVAAVSVGIYQGTPVLDLDYAEDSEAETDMNVVMNEAGGFIELQGTAEGHAFRRDELNAMTELAELGVAQLIETQRQALEA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: SYDP_EDWI9
Sequence: MEHQVSAALREFTQRYVAQWQQQHGDWPSSHALYGIPSPCVVYSRDDCVFWRPEPGRGEDLEGIGRALDIRLHPALAPFFTTQYAGDMRARWNEIEMDLVQVWSVEDLHRLQENQIGHLVTQRRLKLSPTLFLASTADELSMVTLCNLSGSVLLEQFGSPQRRVLAQTLTEFLAELQPLAQEVG
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: RNFC_SERP5
Sequence: MLNLFAAFKKDRIWDFDGGIHPPEMKTQSSGVPLRTAPLPDKFIIPLQQHLGPEGELCVKVGDTVLKGQPLTVGRGRTVPVHAPTSGTISAITPHITAHPSGLAELCVIIQPDGEDRWCERAPVADYRQLTASELIQRIHQAGIAGLGGAGFPTASKLQGGMNGVETLILNAAECEPYITADDRLMQEHADQVIEGTQILRHLLQPKVTLIGIEDNKPEAIAALKLALRGQPGIALRVIPTKYPSGGAKQLTKILIGKEVPHGKHSSAIGVLMQNVGTAFAIKRAIVDGEPLIERVVTLTGEALSLPGNLWARIGTPVQHLLKFAGFQPQAQQMVVMGGPLMGFTLPALHVPIVKISNCILAPSVSEMAPQEQEQSCIRCGLCVDACPAGLLPQQLYWFSRGEEHEKARNHNLFDCIECGACAFVCPSNIPLVQYYRQEKAEIKAIDLEAARTAEAKARYEAKLARLEREKLAREERHKKAAVKLTDGDQDAVQAALARVRSKNAVPATGTISGDAPDNSEMNAAREARKAQARERRAQQETPVAPVTASASEDEDPRKAAVAAALARVKAKKAAPQATAVETPAESPAVVTEEDPRKAAVAAALARVKAKKAAQQATAVETPAESPAVVTEEDPRKAAVAAALARVKAKKAAQQATAVETPAESPAVVTEEDPRKAAVAAAIARAKAKRAAQSLTTADTDKE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rnf electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MOT3_RAT
Sequence: MGAGGPRRGAGPPDGGWGWVVLGACFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPQPRPDPAPPGGRARHRQLLDLAVCTDRTFMVYMVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVTTYCCQRCSKDIPPGPSAEGGTSDTEDVEAERDSEPMPASTEEPGSLEALEVLSPRAGSPEPEEEAVPDLSHESVGGHEAHGQNA
What is the function of this protein?
Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity).  May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity).
What are the official names of this protein?
Monocarboxylate transporter 3, MCT 3, Solute carrier family 16 member 8.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (By similarity). Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity).
Protein: RLUB_XANCP
Sequence: MSDTPRKLSLNKLSLKRDSAPEAPKLEERLHKVLAQAGLGSRRALEQRIADGLIKVNGAVAQTGMSVRSGDKIELDGRSFVASALTESSRVLVYNKPEGEVTTREDPEGRPTVFESLPALKGSRWIAIGRLDINTTGLLLLTTDGELANAMMHPSYEVEREYVVRVRAPEGEEKVPDSMIERLSRGVLLEDGGAKFDEIERIGGTDSHDWFRVVVKEGRNREVRRLWESQGCQVSRLKRTRYGKVSLPRELLRGQSVELAQEKVDALRAELKLEEGAPSALTLQPVIGQRRAAKSTVHVSRDGRSNAYVNGQTSGADEGRELRRFDNLREDRGGRGGRGKPGGFKGGLTVSGEAAAKQSQQRPFKQRGPAKGDRSLPDGNPAAFRSWYVPDGVSTGPSGHRNAGPGGAGTGQPRPYAKKGPGGARPGAGGQGRGAAGGQGQSQGQGQGQRKHPYGHPGNAPSFPSDHANPGFSPYGAARPANESYKRRPPRH
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase B, 23S rRNA pseudouridine(2605) synthase, rRNA pseudouridylate synthase B, rRNA-uridine isomerase B.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: LAC11_ARATH
Sequence: MKMGFLFLFCYLLAFLGYSPVDAAVKKYQFDVQVKNISRICNAKPIVTVNGMFPGPTVYAREGDRVIINVTNHVQYNMSIHWHGLKQYRNGWADGPAYITQCPIQTGQSYLYDFNVTGQRGTLWWHAHILWLRATVYGAIVILPAPGKPYPFPQPYQESNIILGEWWNKDVETAVNQANQLGAPPPMSDAHTINGKPGPLFPCSEKHTFVIEAEAGKTYLLRIINAALNDELFFGIAGHNMTVVEIDAVYTKPFTTKAILLGPGQTTNVLVKTDRSPNRYFMAASPFMDAPVSVDNKTVTAILQYKGVPNTVLPILPKLPLPNDTSFALDYNGKLKSLNTPNFPALVPLKVDRRLFYTIGLGINACPTCVNGTNLAASINNITFIMPKTALLKAHYSNISGVFRTDFPDRPPKAFNYTGVPLTANLGTSTGTRLSRVKFNTTIELVLQDTNLLTVESHPFHLHGYNFFVVGTGVGNFDPKKDPAKFNLVDPPERNTVGVPTGGWAAIRFRADNPGVWFMHCHLEVHTMWGLKMAFVVENGETPELSVLPPPKDYPSC
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products.
What are the official names of this protein?
Laccase-11, Benzenediol:oxygen oxidoreductase 11, Diphenol oxidase 11, Urishiol oxidase 11.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: CH10_STRGN
Sequence: MLKPLGDRVVLKIEEKEEKVGGFVIAGNSHAATKTAAVVAVGQGVRTLTGELVAPSVKAGDKVLVESHAGVEVKDGEETYLLVSEANILAIVE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIP2_YEAST
Sequence: MGTTTSHPAQKKQTTKKCRAPIMSDVREKPSNAQGCEPQEMDAVSKKVTELSLNKCSDSQDAGQPSREGSITKKKSTLLLRDEDEPTMPKLSVMETAVDTDSGSSSTSDDEEGDIIAQTTEPKQDASPDDDRSGHSSPREEGQQQIRAKEASGGPSEIKSSLMVPVEIRWQQGGSKVYVTGSFTKWRKMIGLIPDSDNNGSFHVKLRLLPGTHRFRFIVDNELRVSDFLPTATDQMGNFVNYIEVRQPEKNPTNEKIRSKEADSMRPPTSDRSSIALQIGKDPDDFGDGYTRFHEDLSPRPPLEYTTDIPAVFTDPSVMERYYYTLDRQQSNTDTSWLTPPQLPPQLENVILNKYYATQDQFNENNSGALPIPNHVVLNHLVTSSIKHNTLCVASIVRYKQKYVTQILYTPIESS
What is the function of this protein?
Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation.  Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex.  Involved in the regulation of aging.  Acts as a negative regulator of nuclear SNF1 activity in young cells by sequestering its activating gamma subunit at the plasma membrane.
What are the official names of this protein?
SNF1 protein kinase subunit beta-2, Protein SPM2, SNF1-interacting protein 2.
What is the protein family that this protein belongs to?
Belongs to the 5'-AMP-activated protein kinase beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Resides in the cytosol during growth in glucose. Excluded from the nucleus. There is an age- associated shift in localization from the plasma membrane to the cytoplasm.
Protein: ARGR_SHESH
Sequence: MQANRSQDDLVKTFKAILKEERFGSQSEIVLALQAEGYGNINQSKVSRMLSKFGAVRTRNAKQEMVYCLPAELGVPTAGSPLKNLVLDVDHNQSMIVVRTSPGAAQLIARLLDSIGKPEGILGTIAGDDTIFITPSNIHEIDKTLDTVKSLFNFND
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_BACCR
Sequence: MIKLVLIRHGQSLWNLENRFTGWTDVDLSENGLSEAREAGAILKKNGYTFDVAYTSVLKRAIRTLWIVLHEMDLTWVPIHKSWKLNERHYGALQGLNKDETAQKYGEEQVHIWRRSVDVRPPALTEDDPRYEATDPRYKTLKKGEFPLTECLEDTEKRVLAYWHSEIAPTLKSGNKVIISSHGNTIRSLVKYLDNLSSDGVVSLNIPTSIPLVYELDENLRPIRHYYLSMDGEVPEGEIPKHISF
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: PQQE_PSEPK
Sequence: MPPTPEVGLPLWLLAELTYRCPLQCPYCSNPLDFAAQGQELSTEQWFKVMAEAREMGAAQIGFSGGEPLVRQDLAQLIAEARRLGYYTNLITSGIGLTEARIADFKKAGLDHIQISFQASDEQVNNLLAGSKKAFAQKLEMARAVKAHGYPMVLNFVTHRHNIDKIDRIIELCIALEADFVELATCQFYGWAHLNRLGLLPTRAQLERAERITNEYRDKLKAEGNPCKLIFVTPDYYEERPKACMNGWGNLFLTITPDGTALPCHGARQLPVQFPNVRDHDLHHIWYESFGFNRFRGYEWMREPCRSCDEKEKDFGGCRCQAFMLTGDASNADPVCAKSTDHGIILKAREEAETAQLAIEQMTFRNDRNSRVIARG
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: GRPE_STRGG
Sequence: MTEETPGFEEKPDVPSGATPDDAEPKAADSSEEETAAPAGDLDPTVGLTAQLDQARTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDVGRARDHGELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAEPQPGATPAAAKEEKTDDEESGGTEEV
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNHB1_STAA8
Sequence: MNRQQNDLILQFAAVIIFFMVMVFGFSLFLAGHYTPGGGFVGGLLFASSLVIITIAFDIETMRKIFPLDFKILIGIGLVFCIATPIASWFLGKNFFTHVTFDIPLFILEPVHMTTAVFFDFGVLCAVVGTVMTIIISIGENE
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit B1, Mnh complex subunit B1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VP4_BTV13
Sequence: MPEPHAVLYVTNELSHIVKNGFLPIWKLTGDESLNDLWLENGKYATDVYAYGDVSKWTIRQLRGHGFIFISTHKNVQLADIIKTVDVRIPREVARSHDMKAFENEIGRRRIRMRKGFGDALRNYAFKMAIEFHGSEAETLNDANPRLHKVYGMPEIPPLYMEYAEIGARFDDEPTDEKLVSMLDYIVYSAEEVHYVGCGDLRTLMQFKKRSPGRFRRVLWHVYDPIAPECSDPNVIVHNIMVDSKKDILKYMNFLKRVERLFIWDVSSDRSQMNDHEWETTRFAEDRLGEEIAYEMGGAFSSALIKHRIPNSKDEYHCISTYLFPQPGADADMYELRNFMRLRGYSHVDRHMHPDASVTKVVSRDVRKMVELYHGRDRGTFLKKRLFEHLHIVRKNGLLHESDEPRADLFYLTNRCNMGLEPSIYEVMKKSVIATAWVGRAPLYDYDDFALPRSTVMLNGSYRDISILDGNGAILYLMWRYPDIVKKDLTYDPAWAMNFAVSLKEPIPDPPVPDISLCRFIGLRVESSVLRVRNPTLHETADELKRMGLDLSGHLYVTLMSGAYVTDLFWWFNIILDWSAQNKEQKLRDLKRSAAEVIEWKEQMAERPWHVRNDLIRALREYKRKMGMREGASIDSWLELLRHL
What is the function of this protein?
The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus.
What are the official names of this protein?
Core protein VP4.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP4 family.
What are the subcellular locations of this protein?
Virion.
Protein: RPOZ_STRP4
Sequence: MLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSEKSTLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKRRKEEEEKKIKEQIAKEKEDGEKI
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: FOLD_STRS7
Sequence: MVQIIDGKALAQKMQAALAKKVESLKAEKGIVPGLVVILVGDNPASQVYVRNKERAALAAGFKSETVRLSDSVCQEELIELIEQYNQDDTIHGILVQLPLPHHINDKSIILAIDPKKDVDGFHPMNTGHLWSGRPNMVPCTPAGIMEMFHDYGIELEGKNAVIVGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLAAICRRADILIVAIGQGHFITKDFVKEGAVVIDVGMNRDVNGRLIGDVAFDEVSELASMITPVPGGVGPMTITMLLEQTYQAALRRVSQ
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CSD_SYNY3
Sequence: MVALQIPSLAATVRQDFPILNQEINGHPLVYLDNAATSQKPRAVLEKLMHYYENDNANVHRGAHQLSVRATDAYEAVRNKVAKFINARSPREIVYTRNATEAINLVAYSWGMNNLKAGDEIITTVMEHHSNLVPWQMVAAKTGAVLKFVQLDEQESFDLEHFKTLLSEKTKLVTVVHISNTLGCVNPAEEIAQLAHQAGAKVLVDACQSAPHYPLDVQLIDCDWLVASGHKMCAPTGIGFLYGKEEILEAMPPFFGGGEMIAEVFFDHFTTGELPHKFEAGTPAIAEAIALGAAVDYLTDLGMENIHNYEVELTHYLWQGLGQIPQLRLYGPNPKHGDRAALASFNVAGLHASDVATMVDQDGIAIRSGHHCTQPLHRLFDASGSARASLYFYNTKEEIDLFLQSLQATIRFFSDDDFTV
What is the function of this protein?
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
What are the official names of this protein?
Probable cysteine desulfurase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
Protein: DEOC_CLOB1
Sequence: MKLSKYIDHTLLKPQATEKDILKLIEEAKTYDFASVCVNPSWVKLAYENLKDTDVKVCTVVGFPLGATSTASKVYETKVAIKDGADEIDMVISVGQLKSGNDEYVKEEIKKIVEASKNKLVKVIIETCLLTEEEKVKACTLSKEAGADYVKTSTGFSTGGAKPEDIKLMRETVGKDMGVKASGGIHTREEMEVMIENGATRIGASCGVELVK
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSPO2_MOUSE
Sequence: MRFCLFSFALIILNCMDYSQCQGNRWRRNKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKRNKKKRRKLIERAQEQHSVFLATDRVNQ
What is the function of this protein?
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors.  Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.  Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.  Probably also acts as a ligand for frizzled and LRP receptors (PubMed:21693646).  During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity).
What are the official names of this protein?
R-spondin-2, Cysteine-rich and single thrombospondin domain-containing protein 2, Cristin-2, mCristin-2, Roof plate-specific spondin-2.
What is the protein family that this protein belongs to?
Belongs to the R-spondin family.
What are the subcellular locations of this protein?
Secreted.
Protein: BGLJ_EMENI
Sequence: MYRQEATTVTILAQAPPNWPAPAFDISGFTSAFRPSRRAQRSNTTMGSIDTNSTDAWHTFAIPRLGIPAMRITDGPNGARGTRYFNGVPSACLPCGTALGATFDTDLLFKLGRLLAAECKAKGAHVLLGPTINIQRGPLGGRGFESFSEDPVLSGNSAASYCAGVKDLGIVPTLKHLVCNDQEHERIAVSAMVTERALREIYLMPFQLAIKNARPGALMTSYNKVNGLHASEDPGLLNHIIRKEWGFEGLIMSDWFGTYSVASAVNAGLDLEMPGPTRFRGPALMHALTSNKVSEKTLDDRVRKVLELVQLTSRAGIPEYAPAQKLDRVEDRVLLRQAAADSIVLLKNANEVLPLDPRKKTLVIGPNADIAAYCGGGSASLLAYYTVTPRQGIAEKCEEVVFSQGCYGHKELPLLGDHLKTETGERGYTFRVYTEPATYEDRQPVDVLHMTNSCAFLMDYSHPKISGDTYYATLEGRFEPTESGVYELGLTVAGTGLLYIDGELVIDNKTKQRHGTSFFGIGTVEERGERYLEAGRQHHVFVEYSTAPTSNLKHHGVVSFGPGGVRLGGCRKLDAETAIKQAVQLAAETEQVVVCVGMNGNWESEGFDRPHMDLPPGTDNLVRAVIEAQPNAVIVVQSGTPVTMPWADQAKALVQAWYGGSEGGNGIADVLFGDVNPSAKLPLTFPRDIAHNPSYLSYRSERGRVLYSEDVYVGYRYYDKVKQAPLFHFGHGLSYTTFKLSGLNVQETDPQASDISAEVVQIYVRPPTTASVGRPVRELKGYEKTMLHPGETKEISVTVPMGVATSFWDEGRSAWLSEKGTYAIEVVGTGERNMLSAPLCVQVSRYWNGL
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase J, Beta-D-glucoside glucohydrolase J, Cellobiase J, Gentiobiase J.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPR2_MYOCO
Sequence: MMLFVWTTGLLLLATARGNEVCYSHLGCFSDEKPWAGTLQRPVKSLPASPESINTRFLLYTNENPNNYQLITATDPATIKASNFNLHRKTRFVIHGFIDNGEKDWLTDICKRMFQVEKVNCICVDWQGGSLAIYSQAVQNIRVVGAEVAYLVQVLSDQLGYKPGNVHMIGHSLGAHTAAEAGRRLKGLVGRITGLDPAEPCFQDTPEEVRLDPSDAMFVDVIHTDIAPIIPSFGFGMSQKVGHMDFFPNGGKEMPGCEKNIISTIVDVNGFLEGITSLAACNHMRSYQYYSSSILNPDGFLGYPCASYEEFQKDGCFPCPAEGCPKMGHYADQFQGKANGVEKTYFLNTGDSDNFPRWRYKVSVTLSGEKELSGDIKIALFGRNGNSKQYEIFKGSLKPDARYTHDIDVDLNVGEIQKVKFLWHNNGINLLQPKLGASQITVQSGEYGTKYNFCSSNTVQEDVLQSLSPC
What is the function of this protein?
Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:8130186).  In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (By similarity).  Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (By similarity).  Can completely deacylate triacylglycerols (By similarity).  When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase.  Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (By similarity).  Hydrolyzes medium- and long-chain fatty acyls in galactolipids.  May act together with LIPF to hydrolyze partially digested triglycerides (By similarity).  Hydrolyzes long-chain monoglycerides with high efficiency (By similarity).  In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity).  Also has low phospholipase activity (PubMed:8130186).  In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity).  The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
What are the official names of this protein?
Pancreatic lipase-related protein 2, PL-RP2, Cytotoxic T lymphocyte lipase, Galactolipase, Triacylglycerol lipase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted. Zymogen granule membrane; Peripheral membrane protein. Cell projection, neuron projection. Note=Localizes to neurite tips in neuronal cells.
Protein: YQGF_CORDI
Sequence: MVVQPDIPGDNDPGMGRRLGVDVGTVRIGLAMSDSGARMAMPFETLARETGLKDSDKQDIDRIAEVICDNHIVEVVVGLPRDLKGNGSKSVKHAKDVAFRIRRRMHKNGWEHVAVKMADERLTTVVATQALRASGVSEKKGRRVVDQAAAVEILQSWLDARINVLENRTIP
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTRI_RAT
Sequence: MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGEYECSASNDVAAPVVRRVNVTVNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWFKDDKRLVEGKKGVKVENRPFLSRLTFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVNNGTSRRAGCIWLLPLLVLHLLLKF
What is the function of this protein?
Neural cell adhesion molecule.
What are the official names of this protein?
Neurotrimin, GP65.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. IgLON family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: RS13_ANAPZ
Sequence: MARIGGVNVPVDKRVVVALTYIYGIGTSLANRICEGCGIDKNVRVSALSEEDVVKIRNFIRAGCVVEADLRKEVAMNIKFLMDIGCYRGLRHRKKLPVRGQRTHTNARTRKGGSRLAVAAKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.