PharMolix/UniProtQA huggingface dataset:
Protein: ENGB_PARP8
Sequence: MSFLLHQARFFTTVNHLRDLPPSPQPEVAFAGRSNAGKSTAINILCNQKRLAFASKTPGRTQHINYFSVGPAAEPVANLVDLPGYGYAEVPGAAKAHWEQLLSTYLQTRSQLRGMILMMDSRRPLTELDRRMIEWFAPTGKPIHTLLTKCDKLTRQESVNALRATKKGLDEYRAAGYQGELTAQLFSALKRIGLDEAHELIESWIAPGLAGDPDGPVAAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: KDGA_THETE
Sequence: MSHPLIPFRANFLRAPRVLSMEIVAPVITTFRGGRLDPELFANHVKNITSKGVDVVFVAGTTGLGPALSLQEKMELTDAATSAARRVIVQVASLNADEAIALAKYAESRGAEAVASLPPYYFPRLSERQIAKYFRDLCSAVSIPVFLYNYPAAVGRDVDARAAKELGCIRGVKDTNESLAHTLAYKRYLPQARVYNGSDSLVFASFAVRLDGVVASSANYLPELLAGIRDAVAAGDIERARSLQFLLDEIVESARHIGYAAAVYELVEIFQGYEAGEPRGPVYPLDPEEKAWLRAAVAKAKSQLRL
What is the function of this protein?
Involved in the degradation of glucose via the Entner-Doudoroff pathway.  Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively.  It is not able to use 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal) as substrate.
What are the official names of this protein?
2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase, KD(P)G aldolase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. KDPG aldolase subfamily.
Protein: COAD_THEGJ
Sequence: MRKPYRKVVVGGTFDRLHLGHKALLRKAFEVGRYVYVGLTSDEMIRNKPYAEKILPYELRLMDLLKFFEVNGYTNYRIIKINTAIGFADRIKSLEAIVVSEETYKGALLVNRAREERGLKPLEIVTIKLVKSRIGPKISSTLIRAGLIDPFGNPLKKDN
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRA1_CAEBR
Sequence: MNQPIAAIGISDSTRPKTNVRLTISAEHLMDTDVFSKSDPICLVYEKTSGKKATTTEPVQVPTWQDSQWTERGRTEVVMNNLNPQFTKTFLLPYFFEETQLLRFEIYDADSPNVGQDLSPHDFLGRFECVLAQIVSYSTLKAHLGKAEGIGAQWRNKDKNTRTGSITIRAEEDEKCEKIQFDVCGEGLDKKDFFGKSDPYLNFKRKFDDGSAHLVHRTEVKQKTLDPRWATVQINTQTLCGKDGERPIIIECYDHDKWKKGEEPRGEAKFSRDDHIGTAHTTLNELLRGGAGDPVELLLTNEKKKAKKGDKYKCSGTLKIWNSKIIVEPTFLDFISGGTQLEFAVAVDFTASNGAPKNSSSLHYMSADRPNQYELALRSVLSICQHYNSSKTFEAFGFGAKLPNSVSVSAIFSLDLLRGTPEVVGISGVMSAYRHALQNVQLYGPTNFAPIIDTVAQKAQNMIHDSARYQILLIITDGIISDMHATIRSIINASGLPLSIIIIGVGNEDFEKMHELDSDDSLLQQDSRIAQRDIVQFVTIREFLNNGRGVYLDPDVVQENLAREVLFEVPGQLTGYMKQRGFQPRPVENPWTRNSPPPDYDPVLDGIGRRAQAPSPGFQMPVASAPPMY
What is the function of this protein?
Exhibits calcium-dependent phospholipid binding properties.  May function in membrane trafficking.  Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord.  Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole.  Affects directional sperm motility.
What are the official names of this protein?
Nicotinic receptor-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the copine family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LIPA_SHEAM
Sequence: MNRPERLQPGVKLRDADKVARIPVKIMPSERETMLRKPDWLRVKLPASNQRITEIKQALRSNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPLKPDADEPVKLAKTIRDMKLKYVVITSVDRDDLRDGGAQHFADCIREIRALNPHIQIETLVPDFRGRIDVALDILSTNPPDVFNHNLETAPAHYRKARPGANYQWSLDLLKRFKERHPNIPTKSGLMMGLGETNEEIIQVLKDLRAHDVNMLTLGQYLQPSKFHLPVERYVSPQEFDELKVIAEDLGFSHAACGPLVRSSYHADLQAQGKEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_ENT38
Sequence: MSLFDKKQLVSQADALPGRNTPMPVATLHAVNNHSMTNVPDGMEIALFAMGCFWGVERLFWQLPGVYSTAAGYTGGYTPNPTYREVCSGETGHAEAVRIVYDPSVTRYEQLLQVFWENHDPAQGMQQGNDHGTQYRSAIYPLTPEQDAAARASLARFQDAMQAAGDHRTVTTEIANATPFYYAEDDHQQYLHKNPYGYCGIGGIGICLPPQLA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: EFEU_ECOLI
Sequence: MFVPFLIMLREGLEAALIVSLIASYLKRTQRGMXDCVMWIGVLLAAALCLGLGIFINETTGEFPQKEQELFEGIVAVIAVVILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNHHGWALVMMVFFAVAREGLESVFFLLAAFQQDVGIWPPLGAMLGLATAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFGYQEAPSVSEVAVWFIYLIPALVAFALPPRAGATASRSA
What are the official names of this protein?
Putative inactive ferrous iron permease EfeU, Putative Fe(2+) ion permease EfeU.
What is the protein family that this protein belongs to?
Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NSP_TGMVY
Sequence: MYSTKYRRGFLANQGRGYPRHSTGKRSRNVSRIDFKRRSSKYVHGNDDSKMANQRIHENQFGPEFVMVHNTAISTFITFPSLGKTEPSRSRSYIKLKRLRFKGTVKIERVHVDLSMDGPSPKIEGVFSLVVVVDRQPHLSPTGCLHTFDELFGARIHSHGNLAVSSALKDRFYIRHVFKRVISVEKDSTMIDLEGMTSFTNRRFNCWSAFKDFDRQACNGVYGNISKNAILVYYCWMSDIVSKASTFVSFDLDYVG
What is the function of this protein?
Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus.  Begomoviruses use 2 proteins to transport their DNA from cell to cell.  The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall (By similarity).
What are the official names of this protein?
Nuclear shuttle protein, NSP, Protein BR1, Protein BV1.
What is the protein family that this protein belongs to?
Belongs to the begomovirus nuclear shuttle protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocated to the plasma membrane by the movement protein BC1.
Protein: GSH1_CAEEL
Sequence: MGLLTKGSPLTWAETVPHIDYIKKHGIAQFINLYHRLKSRHGDQLKWGDEIEYTIVKFDDANKKVRVSCKAEELLNKLQAEEQVNAMLGTANRFLWRPEFGSYMIEGTPGMPYGGLIACFNIVEANMKLRRQVVKKLLKKDETCLSISFPSLGVPGFTFPEVAADRKNDDAANSVFWPEQAVFLGHPRFKNLTKNIKGRRGSKVAINVPIFKDTNTPSPFVEDLSALGGPDDTRDAKPDHIYMDHMGFGMGCCCLQVTFQAVNVDEARWLYDQLTPITPILLALSAATPIFRGKLSNVDSRWDIISASVDDRTPEERGLEPLKNSKWVIDKSRYDSTDCYIYPCSVGYNDIPLQYDETIYKQLIDGNIDEPLAKHIAHMFIRDPHQVFRERIEQDDEKSSEHFETIQSSNWMNMRFKPPPPDAPEIGWRVEFRPTEVQLTDFENAAYCCFVVLLTRMMISFRLTYLMPISMVTENMKRAQQKDAVLNQKFLFRKGLAECKSAPENLKGSEKCGPPSQDIEEMSIDEIINGKKNGFPGLISLIRQFLDSADVDVDTRCTISQYLNFISKRATGEINTLAHWTRGFVQSHPAYKHDSDVNDNIVYDLLKKMDAISNGEDHCEKLLGCYRSKTDHAISAAVRKAEEHMIVSSQKRAH
What is the function of this protein?
Plays a role in resistance to arsenite (PubMed:23593298).  May play a role in the oxidative stress response induced by reactive oxygen species produced during infection by pathogenic bacteria (PubMed:22216003).  Together with trxr-1, required for the reduction of disulfide groups in the cuticle during molting (PubMed:21199936).
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 3 family.
Protein: IACP_SALTY
Sequence: MNMDIEARVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMMTFADICRVVKKSLESRV
What is the function of this protein?
Acyl carrier protein.
What are the official names of this protein?
Probable acyl carrier protein IacP, ACP.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_YERPE
Sequence: MAIVLGIDPGSRVTGYGVIRQQGRQLTYLGSGCIRTVVDDMPTRLKLIYAGVTEIITQFQPDFFAIEQVFMAKNPDSALKLGQARGAAIVAAVNLNLPVSEYAARQVKQTVVGTGAAEKSQVQHMVRSLLKLPANPQADAADALAIAITHCHLSQNTLRLGNDQMTLSRGRIR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: HTPX_PARP8
Sequence: MFNWVKTAMLMAAITALFIVIGGMIGGRSGMMFALLIALGMNFFSYWFSDKMVLRMYNAQEVDETSAPQFYRMIRDLATRANLPMPRVYLIDEDQPNAFATGRNPEHAAVAATTGILRVLSEREMRGVMAHELSHVKHRDILISTISATMAGAISALANFAMFFGGRDENGRPANPIAGIAVALLAPIAGALIQMAISRAREFEADRGGAQISGDPQALASALDKIHRYANGIPFPTAEAHPATAQMMIMNPLAGGGIANLFSTHPSTEERIARLMEMARTGRFE
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NEK6_HUMAN
Sequence: MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST
What is the function of this protein?
Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848).  Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596).  Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783).  Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501).  Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393).  Inhibition of activity results in apoptosis.  May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361).  Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757).
What are the official names of this protein?
Serine/threonine-protein kinase Nek6, Never in mitosis A-related kinase 6, NimA-related protein kinase 6, Protein kinase SID6-1512.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.
Protein: ACNA_MYCAV
Sequence: MQDKRTVKVGTVADTAVGGRTKSLGVEVTDSVNSFGARNRVKVGDKSYQIYRLDAVPNTEKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPKAGASIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPEKVNPLAPADLVIDHSVIADLFGTADAFERNVEIEYQRNGERYQFLRWLQGAFSDFKVVPPRRIVHQVNIEYLARVVMERVGVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLTGEDPAPGAATDVVLTVTEICAKHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIFPIDQETIDYLKFTGRNAEQVALVETYAKEQGLWHDPAHEPAFSEYLELDLSQVVPSIAGPKRPQDRIALSQAKSVFREQIPSYVGDGDGQQGYSKLDEVVDETFPASDPGAPSNGHADDLPAVQSAAAHANGRPSNPVTVRSDELGEFVLDHGAVVIAAVTSCTNTSNPEVMLGAALLARQRVEKGLASKPWVKTTMAPGSQVVHDYYDKAGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISKAINDNDLSVTAVLSGNRNFEGRINPDVKMNYPASPPLVVAYALAGTMTRLEKQPLGKDKDGNDVYLKDICRSQKTLGHHPIGDNSEWFTKNYADVFKGEQAWRNLPTPTRNTFEWSPDSTYVRKPPYFEGMPAEPEPVADISSARVVALLGDSVTTDHISPAGSIKPGTPAAQYLDDARRGPQGLQLFGCRRGNHEVMIRGTFANIRLRNLLHDDVAGGYTRDFTQDGGPQAFIYDAAQNYAAQNIPLVVLGGKEYGSGSSRDWAAKGTRLLGVRAVIAESFERIHRSNLIGMGVIPLQFPDGKSAKDLGLDGTEVFDITGIEELNKGKTPKTVHVKASKNGSDAAEFDAVVRIDTPGEADYYRNGGILQYVLRNMLKSG
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate.  The apo form of AcnA functions as a RNA-binding regulatory protein.  Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate.
What are the official names of this protein?
Aconitate hydratase A, ACN, Aconitase, (2R,3S)-2-methylisocitrate dehydratase, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase, Iron-responsive protein-like, IRP-like, Probable 2-methyl-cis-aconitate hydratase, RNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: DCYD_YERPP
Sequence: MTLQQKLTQFPRLDLVGNATPLEKLSRLSDYLGREIYIKRDDVTPVALGGNKLRKLEFLAADALRQGADTLVTAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTEQANYLTNGNRLLLDLFNVDVVMCEALNDPNQQLAELATRVEAQGFRPYVVPIGGSNALGALGYVQCSLEIAAQAAGNVAFSSVVVASGSAGTHAGLAVGLQQLLPDAELIGVTVSRSADEQRPKVAQIQQALATSLGMTDPLAKITLWDSYFAPQYGMPNEEGIAAIKLLARLEGILLDPVYTGKAMAGLLDGIEQQKFCDKGPILFIHTGGAPALFAYHPQV
What is the function of this protein?
Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives.  It could be a defense mechanism against D-cysteine.
What are the official names of this protein?
D-cysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: LSRF_SHIF8
Sequence: MQSRLSWIFNPKTGKTVMLAFDHGYFQGPTTGLERIDINIAPLFEHADVLMCTRGILRSVVPPATNKPGVLRASGANSILAELSNEAVALSMDDAVRLNSCAVAAQVYIGSEYEHQSIKNIIQLVDAGMKVGMPTMAVTGVGKDMVRDQRYFSLATRIAAEMGAQIIKTYYVEKGFERIVAGCPVPIVIAGGKKLPERETLEMCWQAIDQGASGVDMGRNIFQSDHPVAMMKAVQAVVHHNETADRAYELYLSEKQ
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
What are the official names of this protein?
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_STRP6
Sequence: MKLVLQRVKEASVSIDGKIAGAINQGLLLLVGVGPDDNAEDLAYAVRKIVNMRIFSDADGKMNQSIQDIKGSILSVSQFTLYADTKKGNRPAFTGAAKPDLARQLYDSFNEQLAEFVPVERGVFGADMQVSLINDGPVTIILDTKCH
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPR34_GORGO
Sequence: MRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 34.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TXD2A_SCOMU
Sequence: MAYIYALIFAIVVCMNTDVIQAEESQHDTLENVEYRLSCIPKGGECERMADTCCPGLQCLGCNPFNKENLGKCKCQ
What is the function of this protein?
Inhibits voltage-gated calcium channel (Cav) currents in DRG neurons (IC(50)=1590 nM).
What are the official names of this protein?
Omega-scoloptoxin(13)-Ssm2a, Omega-SLPTX(13)-Ssm2a, Omega-scoloptoxin-Ssm2a, Omega-SLPTX-Ssm2a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PANB_EXISA
Sequence: MHTMTTLLKKMNEQEKLVMLTAYDYPSAKLAESAGVDLILVGDSLGMVVLGYDSTIPVTMEDMLHHSKAVRRGAQHTFVVVDMPFASYHGDFDRTLQAASRLFQEGRADAIKLEGAGDVLQTIERLTQVGMPCVAHLGLTPQSVGVLEGYKVQGKSLEAAETLLQDSLAAERAGAKMLVLECVPHQLAKRIAEELTIPVIGIGAGADVDGQVLVYHDVLKYGVDRLPKFVQAYADLNEVATDAIRSYVEETKNGHFPQERHTFTMDESLLDSLYGGK
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AL7B4_ARATH
Sequence: MGSANNEYEFLSEIGLTSHNLGSYVAGKWQANGPLVSTLNPANNQPIAQVVEASLEDYEQGLKACEEAAKIWMQVTAPKRGDIVRQIGDALRSKLDYLGRLLSLEMGKILAEGIGEVQEVIDMCDFAVGLSRQLNGSVIPSERPNHMMLEMWNPLGIVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKLVAEVLEKNNLPGAIFTAMCGGAEIGEAIAKDTRIPLVSFTGSSRVGSMVQQTVNARSGKTLLELSGNNAIIVMDDADIQLAARSVLFAAVGTAGQRCTTCRRLLLHESVYDKVLEQLLTSYKQVKIGNPLEKGTLLGPLHTPESKKNFEKGIEVIKSQGGKILTGGKAVEGEGNFVEPTIIEISADAAVVKEELFAPVLYVLKFKSFGEAVAINNSVPQGLSSSIFTRNPENIFRWIGPLGSDCGIVNVNIPTNGAEIGGAFGGEKATGGGREAGSDSWKQYMRRSTCTINYGNELPLAQGINFG
What are the official names of this protein?
Aldehyde dehydrogenase family 7 member B4, Antiquitin-1, Turgor-responsive ALDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: ASAH1_BOVIN
Sequence: MLGWSRLTFILLSGIVTCLVAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELMVVKAPALKVIVNSMKNIVNAFVPSGKIIHLVDQKLPGLLGNFPGPFEEEMKGIAAVTEIPLGEIILFNIFYEFFTICTSIITEDKEGHLLHGRNLDFGVFLGWNINNDTWVITEELKPLTVNLDFQRNNKTLFKATTFAGYVGMLTGFKPGLFSVTLNERFSIDGGFMGVMEWILGKKDAQWVGFIIRSVLENSTSYEETKNILTKTKILAPAYFILGGNQSGEGCVITRDRKQSLDIYELDPKHGRWYVVQTNYDRWKNPFFLDDRRTPAKMCLNQTTQENISFATIYDVLSTKPILNKLTVYTVLIDVTKGQFETYLRDCPDPCIGW
What is the function of this protein?
Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity).  Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity).  Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity).  For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity).  Has also an N-acylethanolamine hydrolase activity (By similarity).  By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity).  Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity).  By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity).
What are the official names of this protein?
Acid ceramidase, AC, ACDase, Acid CDase, Acylsphingosine deacylase, N-acylethanolamine hydrolase ASAH1, N-acylsphingosine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acid ceramidase family.
What are the subcellular locations of this protein?
Lysosome. Secreted. Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent.
Protein: E2AK3_DROME
Sequence: MQDDLDGIVRHRRRSLSFLQIVTLTMAGLVAFDPAQVLAGHPTTDSELQTAGSPRPPGLEHCVDQEERRVARRLLYISTLDGRLSALDIAKSGKLRWSVPTGPGPLISSSIHRLELTNNGQFVRMIPSLSGGIYKFDGDSIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSVRTGQLLYECSLNGCVNSTEEGLAIDDTIREPDEEDQLEDGEQLRDEAGYIVRHDPLLDDVIIVRRQTQTVRAVESRTGVERWNFSVGQHELDLVRPSECQLQPRDELELAVLDVDIKVVVPEGIICAFSKSEPQTMLWKYKFDHPIVSAWNTNADDELQPIDLFSSAQWLWDQDENDTELPNAPQSPPSIYLGMYDKQLYIQESIRLRQEIMDQTKVYQQLTGDTSLMPRIPWKPISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDENFAVAAQSVLNASEFVNGNGFYFYTTGDLNGPQECSTQNNPTDLPAITAPTSPTNATSEGTEATGNHSVNDDLGFSLDDIDAPVKVVILSLWFWWKEIVVIAFTSAVILNIFMGQRNQRVEREYLVIERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQRTISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTEQLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRAEEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSGSDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKESLRDWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQQYDLLQQMLSAQPEQRPQTKQLKSQLRNILQLPHLLSEGQSEQAELAERARRLSRSRTFSSSSEPHQ
What is the function of this protein?
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis.
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase, PRKR-like endoplasmic reticulum kinase, DmPEK, PEK, PERK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.