PharMolix/UniProtQA huggingface dataset:
Protein: DLTA_STAAS
Sequence: MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVNRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIAEVING
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGAL1_KLEPN
Sequence: MQISDTGRSHTPDFHAVLAREDWHNQTITHLNRLPAHPVFASWRDELAARDNLPSSRRRQLDGSGSSLTPAARLPSMRVVTQDLPDCRGTPVPSNWQMEGYDAPIYTNVRYPIDTTPPRVPEDNPTGCYSLHFTVEDTWRENGQTQIIFDGVNSAFHLWCNGVWVGYSQDSRLPAAFDLSPFLRPGDNRLCVMVMRWSAGSWLEDQDMWRMSGIFRSVWLLNKPQQRLCDVQLTPALDALYRDGTLQVQATIEATEAALAGLSVGVSLWRGEEQFAAGRQPLGTPTVDERGHYAERVDFSLAVATPAHWSAETPNCYRAVVTLWRGDELLEAEAWDIGFRRIEIADGLLRLNGKPLLIRGVNRHEHHHLRGQVVTEADMVQDILLMKQNNFNAVRCSHYPNAPRWYELCNRYGLYVVDEANIETHGMVPMNRLSDDPAWLPAFSARVTRMVQSNRNHPCIIIWSLGNESGGGGNHEALYHWLKRNDPSRPVQYEGGGADTTATDIICPMYARVERDQPIPAVPKWGIKKWISLPGEQRPLILCEYAHAMGNSLGNFADYWQAFREYPRLQGGFIWDWADQAIRKTFADGSVGWAYGGDFGDKPNDRQFCMNGLVFPDRTPHPSLVEAKHAQQYFQFTLLSTSPLRVRIISEYLFRPTDNEVVRWQVQAAGEPLYHGDLTLALPPEGSDEITLLDSLILPEGARAVWLTLEVTQPQATAWSEAEHRVAWQQFPLPAPLGCRRPPCLPALPDLIVSDEVWQIRAGSQCWTIDRRTGLLSRWSVGGQEQLLTPLRDQFIRAPLDNDIGVSEVERIDPNAWVERWRSAGLYDLEAHCVQCDAQRLANETLVDCRWHYLRGEEVVIVSHWRMHFTADGTLRLAVDGERAETLPPLPRVGLHFQVADQQAPVSWLGLGPHENYPDRRSSACFARWEQPLAAMTTPYIFPTENGLRCDTQALDWGRWHISGHFHFSVQPWSTRQLMETDHWHKMQAEDGVWITLDGLHMGVGGDDSWTPSVLPQWLLSQTRWQYEVSLRSL
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: RF1_BORBU
Sequence: MLLEKLNSATSKIKLIEEKLQDINLIKDQKKYSKIIKEYTYLEKINTKKIEYEKILSQINDTKTILEKEDQQEMKELIKQELIDLDKKKEDLEHQIKILLLPQDENDSKNIIIEIRAGTGGEEAALFANNLYSMYIKYSEKKKWKTEIINFNETELGGFKEIIFEIKGKDVFKKLKYESGVHRVQRIPITESNGRLQTSAATVAVLPNIEETEIDINEKDLRIDVYRSSGAGGQHVNTTDSAVRITHLPTGIVVQCQNERSQHKNKDQAMKILRARLYEFEDSKKQEQRSSNRKQQVGSGDRSERIRTYNFPQNRITDHRANITLYKLEEFMQGELDPLLDPLMIALQEQELKSNSI
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NLP_DROME
Sequence: MAEESFYGVTLTAESDSVTWDVDEDYARGQKLVIKQILLGAEAKENEFNVVEVNTPKDSVQIPIAVLKAGETRAVNPDVEFYESKVTFKLIKGSGPVYIHGHNIKDDVEVVDMEEDDEEDDVAEDEEDEHPKKRAKIENAADGKNAKNNKKK
What is the function of this protein?
Inactive for chromatin assembly.  In vitro it appears to form a high molecular mass aggregate with the core histones.
What are the official names of this protein?
Nucleoplasmin-like protein, Chromatin decondensation protein 1, dNLP.
What is the protein family that this protein belongs to?
Belongs to the nucleoplasmin family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CALI_HUMAN
Sequence: MKLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQCITFPIEFNHRPLLSFQQDNILCVHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVCGGVTTASDVQTKDYTINPNAFLLDQKTGKWKTLAPPPEALDCPACCLAKLPCKILQRI
What is the function of this protein?
Possible morphogenetic cytoskeletal element in spermiogenic differentiation.
What are the official names of this protein?
Calicin.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightly associated to the nucleus.
Protein: BGLA_ASPNC
Sequence: MRFTSIEAVALTAVSLASADELAYSPPYYPSPWANGQGDWAEAYQRAVDIVSQMTLAEKVNLTTGTGWELELCVGQTGGVPRLGIPGMCAQDSPLGVRDSDYNSAFPAGVNVAATWDKNLAYLRGQAMGQEFSDKGADIQLGPAAGPLGRSPDGGRNWEGFSPDPALSGVLFAETIKGIQDAGVVATAKHYIAYEQEHFRQAPEAQGYGFNITESGSANLDDKTMHELYLWPFADAIRAGAGAVMCSYNQINNSYGCQNSYTLNKLLKAELGFQGFVMSDWAAHHAGVSGALAGLDMSMPGDVDYDSGTSYWGTNLTISVLNGTVPQWRVDDMAVRIMAAYYKVGRDRLWTPPNFSSWTRDEYGFKYYYVSEGPYEKVNQFVNVQRNHSELIRRIGADSTVLLKNDGALPLTGKERLVALIGEDAGSNPYGANGCSDRGCDNGTLAMGWGSGTANFPYLVTPEQAISNEVLKNKNGVFTATDNWAIDQIEALAKTASVSLVFVNADSGEGYINVDGNLGDRRNLTLWRNGDNVIKAAASNCNNTIVIIHSVGPVLVNEWYDNPNVTAILWGGLPGQESGNSLADVLYGRVNPGAKSPFTWGKTREAYQDYLYTEPNNGNGAPQEDFVEGVFIDYRGFDKRNETPIYEFGYGLSYTTFNYSNLQVEVLSAPAYEPASGETEAAPTFGEVGNASDYLYPDGLQRITKFIYPWLNSTDLEASSGDASYGQDASDYLPEGATDGSAQPILPAGGGAGGNPRLYDELIRVSVTIKNTGKVAGDEVPQLYVSLGGPNEPKIVLRQFERITLQPSKETQWSTTLTRRDLANWNVETQDWEITSYPKMVFAGSSSRKLPLRASLPTVH
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase A, Beta-D-glucoside glucohydrolase A, Cellobiase A, Gentiobiase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: EIF3A_ASPTN
Sequence: MPPPPHIKPENVLKRAQELIAVGQAPAALNVLHEHVTSKRTRSSPISSLEPVMLQIVELCVDMRKGKAAKDGLYQYKNIAQNTNVGTIEVVLKKFIELAEKKVTEAQTKADEIQSSLESAAPSANVEDLEAIETPETILLATVSGEQSRDRTDRAVVTPWLKFLWETYRTVLEILKNNARLEVMYQTTALQAFQFCLKYTRKTEFRRLCELLRNHVQNAAKYSAQMHAINLSDPDTLQRHLDTRFQQLNVAVELELWQEAFRSIEDIHTLLSLSKRPAKNVMMANYYEKLARIFLVSENYLFHAAAWSRYYNLLRQSAATLAAGQGTKKENPSVTEADMTKAASFVLLSALAIPVISTSRSRGALVDVDEVRKNKNTRLTNLLGMAQPPTRAVLFKDAMNKGLLKRARPEIRELYNILEVDFHPLSICKKITPILKQIGSDPEMEKYVVPLQQVILTRLFQQLSQVYESVELKFVYELAQFPDPFQITPAMIEKFIMNGCKKGDLAIRVDHISGVLTFDSDVFSSAKALHPGSAAGSAESEVGSVQRLQNTPAEIARLQLTRLAKTLHVSCMYVDPSYNESRIQAKQTAQARALAGAAKEHEETLARRVIIEKKKEAATDALQRKQREEETRKRIRTQQLQEAEKQRLLDEQREREKKRIKDEQDRIRQQELKKQLEELKSGVKGIDINEIDLQDLDANRLRAMKLAQLEKEKNELNDRIRTTGKRIDHLERAFRREELKHIPEDYEAQKKRDMEIYEATKAETLKEAELKHKEAVALKHRLSRLVPHFNSFRKEVSEKRHEEFEKRRKAAERDFEAKKKQRVKEVQERRRREKMEREMAERQRKEEEERAQREEEEKRARDEERRRVLAEEKAKREEERKRLDEIAAKQKQREEEAEARRAARKAGLEPAAPAARPEPTERTAPRLNIAPRTGGPSWRERQAAKEAAGGAAPEAAPKEEAPQPARRPGGYVPPHLRSGSSAAPAAPPSNGAPERYVPRHARESSSSQPPSRTQTPGSDKPSEGGSAGKWVPRWKQQQNQ
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit A, eIF3a, Eukaryotic translation initiation factor 3 110 kDa subunit homolog, eIF3 p110, Translation initiation factor eIF3, p110 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIF8_TRYB2
Sequence: MTRCRLVGASSGGKYISTTNAKTRPVMGCLRFASRLSALGSTQQPKFFALPLLATTRGFGHLVREVDMRGFRGDFGQLRHKNLASTQRYVTDALGAKKNVIFCGAYHTGKLTILKAIGEACEARGKKVAYVSCNPQRASRFGGFLLYHFVGLRYLFRNEIPSRDQLDGALERHARLCESTYAGCVPSLKSVDVLIFDAVDQLEPTILASMDAVCRRLRGKPNDAFGGLRVFAAADFWRLPVHPSSDTGGYIFQLDNWGELFPKQHLLKKIYGQTKALTTLVNKAYYGQLSAEDIEELEARSSAGRTESGAACGGSKKEASETSGSFSVSDDGSRQVEVEEEGAGSGLLPPQRLISNAEAIIKFTSRFPKQPSIRVLPPRFRTLKRTEIGNYIVNMMVQSSTLHSFGLVDSLNLDIGASVHLLFDGTADFGVTAGTVGEVLQVKEHALVVHFPSVHRTVDVPRMRISVYHPFYPEVRYEVQQFPLYPRHCISPINMLTYHHAYQVHIDCHQLADTNDLGNILARMRTFDDFTIERVHDFAHLDGMVHEPTRIYYQRIDNQPLSSAAEQWCRNCKSYVSTSDFYTHWDKCVRQVRWCTVCNTRIPLERLGPHQEKHQIVLCLDCGRAVEWRRWEGHRLTCSAMMREVSPENEFLPLRTRQLALEMGLDKRDLHTMKGFNRGMLPKSRKQCNGGEA
What is the function of this protein?
Required for the maintenance of mitochondrial (kinetoplast) genome stability.  Essential for cell viability.  Has probably no helicase activity, missing at least two of seven conserved helicase motifs.
What are the official names of this protein?
ATP-dependent DNA helicase-like PIF8, DNA repair and recombination protein PIF8.
What is the protein family that this protein belongs to?
Belongs to the helicase family. PIF1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix, kinetoplast. Note=Localizes primarily to the distal face of the kDNA disk. Localization varies with different kDNA replication stages.
Protein: Y1230_BORA1
Sequence: MLYYAAVFFVIALIAAVLGFGGIAAGAAGIAKILFFVFLVLALLSVLSGALRKK
What are the official names of this protein?
UPF0391 membrane protein BAV1230.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPXC_TERTT
Sequence: MIKQRTLKNEIRATGVGLHTGQKVYLTLRPAPIDAGIVFRRVDLSPAVDIPAHAENVGDTTLSTTLVNGDVRVSTVEHLMSAMAGLGIDNAIVEVSADEVPIMDGSAGPFVFLIQSAGIQEQNAPKKFIRIKKKVVVKDGEKEAAFYPFNGFKVSFGIDFDHPVFKGRKLDATIDFSSTSFVKEISRARTFGFMHEIEYLRSKGLVKGGSLDNAVVVDKYRIMNEDGLRYDDEFVKHKVLDAIGDLYLLGTSLIGEYRAYKSGHGLNNQVLRELMKREDAWELVTFDEEETAPISYIKPLLAV
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: NDK_MYCLB
Sequence: MTERTLVLIKPDAVERQLIGEIISRIERKGLTIAALELRQVGEELASQHYAEHESKPFFGSLLEFITSGPVMAAIVEGPRAVAAVRQLTGGTDPVEKAAPGTIRGDLALETQFNLVHGSDSTASAQREIALWFPGI
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPT_BURA4
Sequence: MTHPTELPLSPLSALQFYATAPYPCSYLDGRIARSQVATPSHLINSDIYTELVKAGFRRSGVFTYRPYCDGCRACVPVRVPVGAFTPSRTQRRMWKRHRALVATVSPLHYDEEHYALYMRYQSARHAGGGMDRDSRDQYEQFLLQSRINSRLVEFRDLDAPGGEPGKLRMVSMIDILGDGLSSVYTFFEPDDQHTSYGTYNILWQIEQAKSLGLPYVYLGYWIRESPKMAYKANFHPLEGLLDGRWNVLDPDRVELPPVDAALARAPLPGGHSGSG
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPZ_ECOLC
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPDLARTLADREISAAVSIDVRNMPESPEIFEQAMSNLPDAFSPQLLFLDADRNTLIRRYSDTRRLHPLSSKNLSLESAIDKESDLLEPLRSRADLIVDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVAAFLDRHTEVHNFIYQTRSYLELWLPMLETNNRSYLTVAIGCTGGKHRSVYIAEQLADYFRSRGKNVQSRHRTLEKRKP
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: GCST_BACVZ
Sequence: MLKRTPLYDVYKEYGGKTIDFGGWELPVQFSSIKEEHEAVRTKAGLFDVSHMGEVEVSGKDALSFLQKMMTNDVADLKPGNALYTAMCYPDGGTVDDLLIYQKSESCYLLVINASNIEKDIAWLTEHTEGDVTLTNQSDGISLLAVQGPNAQSVLAKLTECDLSSLKPFTFIDKADVAGRQVLLSRTGYTGEDGFELYCRNEDAVHLFKEILAAGEHEGLVPCGLGARDTLRFEAKLALYGQELTKDITPIEAGIGFAVKHKKDSDFFGKSVLREQKEKGAPRKLVGLEMIEKGIPRHGYAVKKDGVPIGEVTTGTQSPTLKKNIGLALIKTEFSEVGTEVEVEIRKKTVKAKIVRTPFYKRPKQS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: CLPX_BORBR
Sequence: MPEKKGSADAKVLHCSFCNKSQHEVRKLIAGPSVFICDECIDLCNDIIREEAQATARAAIRSELPTPAEIKTFLDQYVIGQTSPKRMLAVAVYNHYKRIRHGEIKGDEVELSKSNIMLIGPTGSGKTLLAQTLARMLNVPFVMADATTLTEAGYVGEDVENIIQKLLQNCNYDVEKAQRAIIYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPNQDFVQVDTTNILFIVGGAFDGLEKVIRDRTEKSGIGFSAAVRAKSERGVGELFSEAEPEDLIKFGLIPELVGRLPVVATLDELDEAALVQILTEPKNALVKQFQKLFAMEGAELDVRPDALKAISRKALKRKTGARGLRSILEGALLDTMYDLPSQGNVSRVVLEANAVEGDGKPLLIYADESEAASGEKAGRGEVRDAAA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: TOP1_BACSU
Sequence: MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPLNSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPAKKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMSVDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQIVLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMKEVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGEGNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVECDYKEEPQK
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: VMXP_TITSE
Sequence: SPCIIIDYLCVTETCFCERFKTNKELLEYITVMFTGVQNLLDTLNLGIVGVAQDYSDYNERVDTVAHETAHLIGAPHDEEGPCQDT
What are the official names of this protein?
Venom metalloproteinase, VMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ORN_MYCLE
Sequence: MHDELVWIDCEMTGLDLGSDQLIEIAALVTDADLNILGDGVDVVIHIDSTALSSMIDVVAEMHSRSGLINEVESSIVDLVTAESIVLDYINNHVKQPKTAPLAGNSIATDRSFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPAKGLTHRALADIHESIRELRFYRRTAFVPPPGPSTREIAEVVADLSGTPATPGDIDSAYERPNG
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLI_ANADF
Sequence: MQLAELVQTSDVVARTAGRLEKIARLADALRGLAPEERLAGASWLAGELRQGRIGLGPAAVRAALEATAPADAPALAVREVDASLDRLAAARGAGSGRERAALLAALLARASADERDFLARLVLGELRQGALEGVLVEAVARAAAVPAGEVRRAVMMAGALPPVAEAALAEGAAGLSRFRLRLLEPVQPMLAQPAAGVDEALAALGEAALEWKLDGARVQVHKDGGEVRVFSRALRDVTPAVPEVVEAVRRLPASSLVLDGEAIALRGDGAPEPFQVTMRRFGRKLDVAGLREGVPLSVLFFDALHTAGEDLIARPASERHLALAAAVPDALRVPRLVTSDGAAAAAFLEGALARGHEGLLAKSLTAPYEAGRRGASWLKVKRAHTLDLVVLAAEWGSGRREGFLSNLHLGARDPEGGGFVMLGKTFKGMTDAMLAWQTERFRALALGSTDGYVVHLRPELVVEVAFDGLQESSRYPGGLALRFARVKRYREDKRPEEADTIATVRALHARQVAAERGT
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
Probable DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: GREA_LISMF
Sequence: MATEKVFPMTLDGKAKLENELQELKTVKRKEVVERIKIARSFGDLSENSEYDSAKDEQAFVEGRITTIENMIRNAQIIDAAEAHNGLVTLGNTVTFIELPDGEEETYTIVGSAEADPFEGKISNDSPIAKGLLGHKEGEEVTIQTPAGDMSVKIEKITAS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: CYB_HYPSA
Sequence: MTNIRKSHPLIKIINNSFIDLPAPSNISSWWNFGSLLGICLALQILTGLFLAMHYTSDTATAFNSVSHMCREVNYGWVLRYMHANGASMFFICLYLHIGRGLYYGSYMFKETWNMGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGANLVEWIWGGFSVDKATLTRFFAFHFLLPFIISALVMVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGFFMMMLILLCLVLFSPDMLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILIIIPFLHTSKQRSMTFRPFSQCLFWLLVADLLTLTWIGGQPVEHPYIIIGQLASILYFMIIIVIMP
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ENGB_PSESM
Sequence: MQLKNPILGLCQQATFMLSAAKVDQCPDDEGFEVAFAGRSNAGKSSALNTLTHASLARTSKTPGRTQLLNFFGLDEDRRLVDLPGYGYAKVPIPLKLHWQRHLEAYLGSRESLKGLILMMDIRHPMTDFDLLMLDWAIASHMPMHILLTKADKLTYGAAKNTLLKVQAEIRKGWGDAVSIQLFSAPKRMGLEEAYTVLAGWMELEDKAPAE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: CALM_SPIOL
Sequence: MAZZLTDEQIAEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLNLMARKMKDTDSEEELKEAFRVFDKDQNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKVMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: APAG_PECCP
Sequence: MINAPRVCVQVQSFYVESQSEPDEERFVFAYTITVRNLGRHEVQLLGRYWLITNGNGRQTEVQGEGVVGEQPIIHPGSEFQYTSGAVIETPLGTMEGHYHMTDHQGKAFQVSIPVFRLAIPSLIH
What are the official names of this protein?
Protein ApaG.
Protein: MURB_AROAE
Sequence: MPGNSGAAPLPALEPHADLQALNTFGLPARADRLAIVEHPAQLAALLAQPDWAGAPRLVLGGGSNLVLTGDFHGLVLKVAIGGRRLVGDDDDAWYVEAGAGENWHDFVRWTLAQGWPGLENLSLIPGTVGAAPIQNIGAYGLEVAERFASLAVVSLETGASFRLEAADCRFGYRDSIFKHELAGRTLVTSVTFRLPKRWLPVIRYADVAEELAARGSVAPGPIDVSDAVIAIRRRKLPDPAAIGNVGSFFKNPVIDAATLGRLVAGHPDLPHYLQPDGSVKLAAGWLIDRCGWKGRDLGPVGVYERQALVLVNRGGATGTDVRRIAQAIRDDVSRRFGVDLEPEPVFV
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_BRUSU
Sequence: MKPKIFIDGEHGTTGLQIRTRLAERDDLEVISIPEAERRNKDLRADYLRAADIAILCLPDDASKEAVSLLEGHNSTRIIDTSTAHRVHPDWAYGFAELAKGQRERIAEARLVANPGCYPTGAIALVRPLRDAGLLPADYPVSVNAVSGYTGGGKQLIAQMEDRNHPDYLAANNFLYGLPLKHKHVPELQLHGRLDRRPIFSPSVGRFPQGMIVQVPLFLSELEGSPSLAKVHAVLTEHYAGQDIVEVVPLEESAKLPRVDAEELAGKDGMKLFVFGTEDHGQVNLVALLDNLGKGASGAAVQNMNLMLGK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD045_HUMAN
Sequence: MASVSYQKPTSTTVGKQMIFTGPDYIKDYLPKIHQHTSYVGEQHLALEKTGDLRYLWRPASNRSLPAKYKHEYVSEIGWRIPQYNFINKSRLGSGFHIKYEELSQASLDSITHRYQNPWQPKPHVLDMQGKQSRASFAWHMSAFEDTDQRNSKWAILVRQCKSSLPRASKPPKLPKLPKKEKKRKH
What are the official names of this protein?
Uncharacterized protein C4orf45.