PharMolix/UniProtQA huggingface dataset:
Protein: PHZR_PSEFL
Sequence: MFKMELGQLLGWDAYFYSIFAQAMNMEEFTVVALRALRELRFDFFAYGMCSVTPFMRPKTYMYGNYPEHWLQRYQAANYALIDPTVKHSKVSSAPILWSNELFRNCPDLWSEANDSSLCHGLAQPSFNTQGRVGVLSLARKDNAISLQEFEALKPVTKAFAAAALEKISALETDVRAFNTDVEFSERECDVLRWTADGKTSEEIGVIMGVCTDTVNYHHRNIQRKIGASNRVQAVSYAVALGYI
What is the function of this protein?
Positive regulator of phenazine antibiotic production.  May activate the phenazine biosynthetic genes by binding to a DNA sequence upstream of them, or to an intermediate gene which, in turn, interacts with them.
What are the official names of this protein?
Transcriptional activator protein PhzR.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-regulated transcriptional regulatory protein family.
Protein: RS12_MYXXA
Sequence: MPTISQLVRKGREKLVVKGKSPALKESPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGIEVTSYIPGVGHNLQEHSVVMIRGGRVKDLPGVRYHIVRGTLDSVGVAGRKQSRSKYGAKRPS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RS2_STRA5
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQQTVKLADQAYEFVRDAAANDAVILFVGTKKQAAEAVAEEAKRAGQYFINHRWLGGTLTNWGTIQKRIARLKEIKRMEEEGTFELLPKKEVALLNKQRARLEKFLGGIEDMPRIPDVMYVVDPHKEQIAVKEAKKLGIPVVAMVDTNADPDDIDVIIPANDDAIRAVKLITSKLADAVIEGRQGEDADVDFAQEAQADSIEEIVEVVEGSNND
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RS16_NEIM0
Sequence: MVVIRLARGGSKHRPFYNVIVTDSRSRRDGRFIERVGFYNPVANEKQERVRLNADRLNHWIAQGAQVSDSVAKLIKEQKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: GLYA_AGRVS
Sequence: MANTDAFFSRPLAETDPDIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQFVDIAEELAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRQDDNLLDMDAVAESARKHKPKLIIAGGTAYSRIWDWKRFREIADEVGAYLMVDMAHIAGLVAGNQHPSPFPHCHVATTTTHKSLRGPRGGMILTNDEDLAKKFNSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFQDYAAQVVKNAKALSETLVKGGLDIVSGGTDNHLMLVDLRKKNATGKRAEAALGRAYVTCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFKEAEFIEIGNLIVEVLDGLKVANSDEGNSAVEASVRDKVIGLTGRFPMYPYL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP2A3_MOUSE
Sequence: MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEPCLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK
What is the function of this protein?
Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226).  Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity).  Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226).  May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (By similarity).
What are the official names of this protein?
Small proline-rich protein 2A3.
What is the protein family that this protein belongs to?
Belongs to the cornifin (SPRR) family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen.
Protein: RBL_XANP2
Sequence: MGADAAIGQIKDAKKRYAAGVLKYAQMGYWDGDYQPKDTDVLALFRITPQDGVDAVEAAAAVAGESSTATWTVVWTDRLTAADMYRAKAYKVEPVPGQPGQYFCWVAYDLDLFEEGSIANLTASIIGNVFSFKPLKACRLEDMRLPVAYVKTFRGPPTGIVVERERLDKFGRPLLGATTKPKLGLSGKNYGRVVYEGLKGGLDFVKDDENINSQPFMHWRDRFLYCMEAVNKAQAETGEVKGHYLNITAGTMEEMYRRAEFAKELGSVVVMVDLIVGWTAIQSISNWCRENDVLLHMHRAGHGTYTRQKGHGISFRVIAKWLRLAGVDHLHTGTAVGKLEGDPMTVQGYYNVCRETVTKTDYTRGIFFDQDWAGLRKVMPVASGGIHAGQMHQLIDLFGEDVVLQFGGGTIGHPDGIQAGAIANRVALETMILARNEGRDIKNEGPEILIEAAKWCRPLRAALDTWGEVTFNYASTDTSDFVPTASVA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: Y1209_THEGJ
Sequence: MRKGSLKEVLAKIKHDPREDERDYYIVIEHRGAYGNEKKIPVEMIELGHGYFFIGETQIPYHRIIRVVKGNGKVVWEKRRRKQ
What are the official names of this protein?
UPF0248 protein TGAM_1209.
What is the protein family that this protein belongs to?
Belongs to the UPF0248 family.
Protein: Y4618_METAC
Sequence: MGVRKQTMVKDTAVPIENKKFTREKKDKEKDKKPDRERAGRKTGFFVPKKVETGKKGKLGRKSEGKAEEKAEGKAGISTSTISERAVLKPSAGKRKKAESGPGTKTGKKEKKQKKSFSSSLPASKFLPMSPEEVKARGWKELDIILVTGDAYVDHSSFGTAIIGRVLEDAGFRVGIIAQPRWDNPEDLKKLGRPRLFFSVSAGNTDSMVSNLTPGLKPRKKDAYSPGNKTGLRPNRSVIIYSNRIKEAFPNVPIVLGGIEASLRRFAHYDYLSDKVRQAILADAPADLVVYGMGELQIVEIAKRLQAGEDIRKIRDIPGTVWKMEVRAWKELKEKGKGTNEAVARDTAPEAAEFFKEYIEIPSFSEVSQDKAAFAKAFRTYFLEQNPITGKGIVQPHPKTVIVQNRPMRPLTEAELDHVYELPYTGEAHPSYTEPIPALEMVKFSLTTHRGCFGGCSFCAITQHQGRMITSRSIESVLREAKKLTEKPDFKGIINGVGGPTANMYGMGCRSWEKQGACLDKACLYPRVCPALDTSHKKLLELMKRLRELPGVKHVFTGYGVRYDLALEDEEYLEELCTHHISGQLRIAPEHFSKRVTDAMSKPGKKVYERFSEKFAAFNKKCGKEQYIVNYLMSGHPGCTLKDMIEMAEYLRDHGGYTEQVQDFTPTPMTVSTCMYYTGLDPFTGKKVYVAKDKKEKAMQRALMHYRSPANYELVYEALEKAGRLDLVGNAHKCLIRRKEKQ
What are the official names of this protein?
UPF0313 protein MA_4618.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the UPF0313 family.
Protein: RS10_PLARO
Sequence: MAGQKIRIRLKAYDHEVIDSSAKKIVETVTRTGAKVAGPVPLPTEKNVYCVIRSPHNDKDSREHFEMRTHKRLIDIIDPTPKTVDSLMRLDLPAGVDISIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RL31B_CORDI
Sequence: MKKDIHPDYHPVVFQDAGTGHQFLTKSTATSDRTVAWEDGNEYPLIVVDVTSESHPFWTGAQRVMDTAGRVEKFNQRYGALARRKKNK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: ARI16_ARATH
Sequence: MEADGQKYSVLAKTQVREKMMKEIEQISEVFLVSKSDATVILIRLGWNSFKASDLLGDNKEKFLAKLGLARVLNSNSSSADRETGDGDYLVSTPFCSHKFSTTCWSEYLSDALKKNKEQRGLISCLSQDCVASVGPDTIEQLTEPVKEMYENYILESFMECHKATIKWCPASGCEYAVELQEDGNEDNVISVVCLCGHTFCWTCGLESHRPVSCKKASIWWTYLLDQSRSISWIHTNTKSCPKCKIPVQQNGDPNYRLINCICSNNFCWICLRTEEQHQGNWNCSPVAVPAAGPSTVEFSQILHLNLWEAGHEALKKAKSKLRALEEKIIPKLIENCGATELDIRTVREAGMLSVQCRQVLKWSCVFDYSIIEYESTKKQYLKHLRALASTMLCMHEGKLDELIHLALSPEDFTNYKHKLEISTTCTGNHFDGFIKELEDGKPEVKADGYENEPGSRWFCDRCTFENSWVDKQCKMCFFPLDYHPSPQVAAAPEDLGKSE
What is the function of this protein?
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase ARI16, ARIADNE-like protein ARI16, Protein ariadne homolog 16, RING-type E3 ubiquitin transferase ARI16.
What is the protein family that this protein belongs to?
Belongs to the RBR family. Ariadne subfamily.
Protein: PLPHP_DICDI
Sequence: MMDENDVKELISSYKNIKDRVEIISNKFDRHNVKLVAVSKTKPTEMIRILYDKGHRHFGENYIQELVSKSEELSELNEIKWHFIGSIQSNKSKILTSVKNLYVVETVENKKILDKLAKSLLNNEENNNNNNNNNNKKLNIMIQVNTSGEESKSGCKPEECLDLVKHCLEDNNCKNSLNFLGLMTIGNPNATPDQPDFKCLVDCKNNISKQLNIPLDSIELSMGMSHDFEPAIEFGSTSVRVGSAIFGERDYSNKK
What is the function of this protein?
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
What are the official names of this protein?
Pyridoxal phosphate homeostasis protein, PLP homeostasis protein.
What is the protein family that this protein belongs to?
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Protein: CHLN_CYCTA
Sequence: MSAKISETLTFECETGNYHTFCPISCVSWLYQKIEDSFFLMVGTKTCGYFLQNTLGVMIFAEPRYAMAELEEGDISAQLNDYEELKRLCIRIKKDRDPNVIIWIGTCTTEIIKMDLEGMAPKLESEIGIPIIVARANGLDHAFTQGEDTVLAAMAHRCLEQRLFVRERNGTIQKFPPPLEKEGEFIEYGDHPSLALFGSLPSNVASQLSPELRRQSVKVSGWLPAQRYTHLPSLGNGVYVCGINPFLSRTAATLVRRERCRLIGAPFPIGPDGTRAWIEKICPVFDIETQGLEEREKQIWESLKDYISLVHGKSVFFMGDNLLEISLARFLIRCGMIVYEIGIPYMDKRYQAAELALLRDTCIKMCVPIPRIVEKPDNYNQLRRIRELQPDLAITGMAHADPLEARGMNTKWSVEFTFAQIHGFANARNVLELVTRPLRCNDNLEDLGRTTLVK
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EFG_HAES1
Sequence: MARTTPISLYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMSQQFPQHRINVIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRTGANFLRVVEQIKTRLGGNAVPLQLPIGAEDNFKGVVDLIKMKAINWNEADQGMTFTYEDIPAEMLAECEKWRANLVEAAAESSDELMDKFFSGDELTEEEIKKGLRLRALKTEIILVTCGSAFKNKGVQAMLDAVIDYLPAPTDIEAIKGINPDETEGERHASDDEPFAALAFKIATDPFVGNLTFFRVYSGVVESGATVLNSVKDKRERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVGTGDTLCAMDAPIILERMEFPEPVISVAVEPKTKADQEKMGLALGRLAQEDPSFRVHTDEESGETIISGMGELHLDIIVDRMRREFKVEANIGKPQVSYRETIRTRVNDVEGKHAKQSGGRGQYGHVVIDLYPLEPEGPGYEFVNEIKGGVIPGEYIPAVDKGIQEQLKSGPLAGYPVVDLGVRLHFGSYHDVDSSELAFKLAASLAFKAAFNKANPVLLEPIMKVEVETPPDYVGDVIGDLSRRRAMVSGQEANEFVVKINAEVPLAEMFGYATDLRSQTQGRASYSMEPLKYAEAPKNVADAVIEARKK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYCE3_MOUSE
Sequence: MADSDPGERSYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFLNCKEEMEKNWQELLTETKRKQ
What is the function of this protein?
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.  Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes.  Chromosome loading appears to require SYCP1.  Required for fertility.  May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.
What are the official names of this protein?
Synaptonemal complex central element protein 3, Testis-specific expressed protein 2, TSEG-2.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with SYCE1 in the central elements.
Protein: Y326_STRSV
Sequence: MMNMQSMMKQAQKLQKQMEKGQAELAATEFTGKSAQDLVVAKLTGDKKVVSIDFNPAVVDPEDLETLSEMTAQALNHALAQIDDATQKKMGAFAGKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein SSA_0326.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PEPD_RAT
Sequence: MASTVRPSFSLGNETLKVPLALFALNRQRLCERLRKNGAVQAGSAVVLQGGEEMQRYCTDTSIIFRQESFFHWAFGVIESGCYGVIDVDTGKSTLFVPRLPASYATWMGKIHSKEHFKEKYAVDDVQYADEIASVLTSRNPSVLLTLRGVNTDSGNVCREASFEGISKFTVNNTILHPEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELTRIGLLSGSVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPEGVERIDEPGLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFGGVRIEEDVVVTDSGMELLTCVPRTVEEIEACMAGCDKALAPSGPK
What is the function of this protein?
Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position.  The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved.  Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Peptidase D, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.
Protein: RS19_LACE2
Sequence: MARSLKKGAFADESLLKKVDALNAANDKQVIKTWSRRSTIYPQFVGHTIAVHDGRKHVPVYVTEDMVGHKLGEFVATRTYRGHGKDEKKSR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: RS9_THIDA
Sequence: MIGNYNYGTGRRKSSVARVFIKAGSGKIVVNDKPVDEYFSRETGRMIVRQPLVLTDNLNRFDIMVNVAGGGESGQAGAVRHGITRALIDLDAGMKPTLKAAGLVTRDAREVERKKVGFHKARRRKQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RESA_PLAFN
Sequence: EFRYSQYKVQYDMPKEAYESKWTQCIKLIDQGGENLEERLNSQFKNWYRQKYLNLEEYRRLTVLNQIAWKALSNQIQYSCRKIMNSDISSFKHINELKSLEHRAAKAAEAEMKKRAQKPKKKKSRRGWLCCGGGDIETVEPQQEEPVQTVQEQQVNEYGDILPTLRASITNSAINYYDTVKDGVYLDHETSDALYTDEDLLFDLEKQKYMDMLDTSQEESVEENEEEHTVDDEHVEEHTADDEHVEEPTVADDEHVEEPTVADEHVEEPTVAEEHVEEPTVAEEHVEEPASDVQQTSEAAPTIEIPDTLYYDILGVGVNADMNEITERYFKLAENYYPYQRSGSTVFHNFRKVNEAYQVLGDIDKKRWYNKYGYDGIKQVNFMNPSIFYLLSSLEKFKDFTGTPQIVTLLRFFFEKRLSMNDLENKSEHLLKFMEQYQKEREAHVSEYLLNILQPCIAGDSKWNVPIITKLEGLKGSRFDIPILESLRWIFKHVAKTHLKKSSKSAKKLQQRTQANKQELANINNNLMSTLKEYLGSSEQMNSITYNFENINSNVDNGNQSKNISDLSYTDQKEILEKIVSYIVDISLYDIENTALNAAEQLLSDNSVDEKTLKKRAQSLKKLSSIMERYAGGKRNDKKAKKYDTQDVVGYIMHGISTINKEMKNQNENVPEHVQHNAEANVEHDAEENVEHDAEENAEENVEENVEEVEENVEENVEENVGEKKMRREEKKKRVQEPIKIDEIQVYDIIKNEKKKKTEF
What is the function of this protein?
May disrupt the normal intermolecular interactions of the cytoplasmic domain of band 3 and thereby facilitate the invagination of the red cell membrane which is necessary for the formation of the parasitophorous vacuole.
What are the official names of this protein?
Ring-infected erythrocyte surface antigen.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Probably located on the cytoplasmic face of the membrane where it associates with components of the membrane skeleton.
Protein: YAAA_SALSV
Sequence: MLILISPAKTLDYQSPLATTRYTQPELLDHSQQLIQQARQLSAPQISRLMGISDKLADLNATRFHDWQPHFTPDNARQAILAFKGDVYTGLQAETFNDADFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENPRGKDLYQFWGDIITDKLNEALEAQGDRVVVNLASEEYFKSVKPKKLNAELIKPVFLDEKNGKFKVVSFYAKKARGLMSRFIIENRLTKPEQLTAFDREGYFFDEETSTKDELVFKRYEQ
What are the official names of this protein?
UPF0246 protein YaaA.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: PIP_CAVPO
Sequence: MLTFQFLFRASPATLLLTLYLQLGVITAQEDTRRTIILSTELPQEVTANELTTLKLKVETELRECMVIKAYLVSSKPLAGPFNYKYTGCLCSDYPRTFYWDFQTNSTVRIATVVDIIRELNICPDDQAVVPIKSNRYYAITDLTVN
What are the official names of this protein?
Prolactin-inducible protein homolog, Prolactin-induced protein.
What is the protein family that this protein belongs to?
Belongs to the PIP family.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVC_XANOP
Sequence: MSNDTQPKIAIIGYGSQGRAHALNLRDSGFDVTVGLRPGGPTESKAQADGFTVVAPSEAVKSADLVAILTPDMVQKKLYEDVIAPNMKQGACLLFAHGLNVHFDMITPRADLDVVLVAPKGPGALVRREYEIGRGVPCIYAVYQDTSGKAEQFALTYAGGLGGARANIIKTTFKEETETDLFGEQAVLCGGASSLVQAGFEVLVEAGYQPEIAYYEVLHELKLIVDLFYEGGITRMLEFVSETAQYGDYVSGPRVIDASTKARMKDVLTDIQNGTFTKNWVAEYEAGLPNYTKFKQADLEHPIEEVGKKLRAKMVWLNGEQQAAAAPANQQAA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: UVRB_RICFE
Sequence: MNNFSIISEYKPAGDQPKAIDEIIAGLNSKKRSQMLLGITGSGKTFTMANIIERTNRPTLIMAHNKTLAAQIYSEMKSIFPKNAVEYFVSYYDYYQPEAYIARTDTFIEKDSSINEQIDLMRHSATRSLLERRDVIVVSSVSCIYGLGSPDLYYQMTVNLEPGKSYPRDKLLNDLINLQYERNDIGFERGCFRVKGDNIDIFPSHYSDKAWRLSFFGNELEYIHEFDPLTGEKLAKLDKAMVFGNSHFVMPQETVNSAISGIEEELQKRLEFLKSQDKPLETQRLNQRTQYDLEMLTETGSCKGVENYSRFFTGRNAGEPPPTLFEYLPEDALLFVDESHVSVPQIRAMYNGDRARKEVLVEHGFRLPSALDNRPLKFEEWEKFRPQTVFVSATPGPFELEETGDTVVELIIRPTGLLDPECIIKPATNQVEDLIGEIQATIAKGFRVLVTTLTKKMAEDLTAYLQELKYKTSYLHSNIHTLERIEILRDLRQGTIDILVGINLLREGLDIPECGLVAILDADKEGFLRSEVSLIQTIGRAARNSEGRVILYADKMTKSIDKAMSETSRRRQIQQEYNEKHGIIPKTINRAIHALAELEKVDSKLDKKQAHTLFDNPAKLKAHIEKLKKDMLKAASNLEFEQAAKLRDQLKTLEEAALELS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFIT2_HUMAN
Sequence: MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAYLKHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKVKHVCEKFSSPYRIESPELDCEEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAKVFQVMNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKEFSKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREKEKMKDKLQKIAKMRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLESGSLIPSASSWNGE
What is the function of this protein?
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap.  The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection.  Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism).  Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity.  Can promote apoptosis.
What are the official names of this protein?
Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54.
What is the protein family that this protein belongs to?
Belongs to the IFIT family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: RAN_XENTR
Sequence: MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNFEFVAMPALAPPEVVMDPALAAQYEQDLQHAQATALPDEDDDL
What is the function of this protein?
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs.  Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis.  Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way.  Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport.  Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins.  RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation.  Required for normal progress through mitosis.
What are the official names of this protein?
GTP-binding nuclear protein Ran, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Nucleus. Nucleus envelope. Cytoplasm, cytosol. Cytoplasm. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis (By similarity).