PharMolix/UniProtQA huggingface dataset:
Protein: OAC1_YEAST
Sequence: MSSDNSKQDKQIEKTAAQKISKFGSFVAGGLAACIAVTVTNPIELIKIRMQLQGEMSASAAKVYKNPIQGMAVIFKNEGIKGLQKGLNAAYIYQIGLNGSRLGFYEPIRSSLNQLFFPDQEPHKVQSVGVNVFSGAASGIIGAVIGSPLFLVKTRLQSYSEFIKIGEQTHYTGVWNGLVTIFKTEGVKGLFRGIDAAILRTGAGSSVQLPIYNTAKNILVKNDLMKDGPALHLTASTISGLGVAVVMNPWDVILTRIYNQKGDLYKGPIDCLVKTVRIEGVTALYKGFAAQVFRIAPHTIMCLTFMEQTMKLVYSIESRVLGHN
What is the function of this protein?
Transports oxaloacetate and sulfate.
What are the official names of this protein?
Mitochondrial oxaloacetate transport protein, Mitochondrial carrier protein PMT.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FUS_NDVH4
Sequence: MGSRPSTKIPAPMMLTIRVALVLSCICPANSIDGRPLAAAGIVVTGDKAVNIYTSSQTGSIIVKLLPNLPKDKEACAKAPLDAYNRTLTTLLTPLGDSIRRIQESVTTSGGGRQGRLIGAIIGGVALGVATAAQITAAAALIQAKQNAANILRLKESIAATNEAVHEVTDGLSQLAVAVGKMQQFVNDQFNKTAQELDCIKIAQQVGVELNLYLTELTTVFGPQITSPALNKLTIQALYNLAGGNMDYLLTKLGIGNNQLSSLIGSGLITGNPILYDSQTQLLGIQVTLPSVGNLNNMRATYLETLSVSTTRGFASALVPKVVTQVGSVIEELDTSYCIETDLDLYCTRIVTFPMSPGIYSCLSGNTSACMYSKTEGALTTPYMTIKGSVIANCKMTTCRCVNPPGIISQNYGEAVSLIDKQSCNVLSLGGITLRLSGEFDVTYQKNISIQDSQVIITGNLDISTELGNVNNSISNALNKLEESNRKLDKVNVKLTSTSALITYIVLTIISLVFGILSLILACYLMYKQKAQQKTLLWLGNNTLDQMRATTKM
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: PNCC_ENTAG
Sequence: MSEKRLHELSVEIGAALKAKGWWVTCAESCTGGLIAKAITDIAGSSAWFDRGFVTYSNAAKHELLGVSESTLEQYGAVSEQVVHEMALGVLHAAGADVAVSVSGIAGPDGGSAEKPVGTVWFGFAGKDGRVLTAKQQFSGDREAVRLQAAVFSLQTALREFIKN
What is the function of this protein?
Has NMN aminohydrolase activity, not active on other substrates.
What are the official names of this protein?
Nicotinamide-nucleotide amidohydrolase PncC, NMN amidohydrolase PncC, NMN deamidase, Nicotinamide-nucleotide amidase.
What is the protein family that this protein belongs to?
Belongs to the CinA family. PncC subfamily.
Protein: MRAZ_SALSV
Sequence: MFRGATLVNLDSKGRLTVPTRYREQLIESATGQMVCTIDIHHPCLLLYPLPEWEIIEQKLSRLSSMNPVERRVQRLLLGHASECQMDGAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSATETLSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RSMH_BACTN
Sequence: MEKDELTYHVPVLLKESVDGMNIHPDGTYVDVTFGGAGHSREILSRLGEGGRLLGFDQDEDAERNIVNDPHFTFVRSNFRYLQNFLRYHDIEQVDAILADLGVSSHHFDDSERGFSFRFDGALDMRMNKRAGLTAADIVNTYEEERLANIFYLYGELKNSRKLASAIVKARNGQSIRTIGEFLEIIKPLFGREREKKELAKVFQALRIEVNQEMEALKEMLAAATEALKPGGRLVVITYHSLEDRMVKNIMKTGNVEGKAETDFFGNLQTPFRLVNNKVIVPDEAEIERNPRSRSAKLRIAEKK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KN12E_ARATH
Sequence: MPFISETASAIKRRFGFNDRPAPSESLRSVPCTPEANTVSRDNHTHQSLLFSSAVRSMPELDEDGAICAGSAQISRSQSFEFNEDPAFWKDHNVQVIIRTRPLSSSEISVQGNNKCVRQDNGQAITWIGNPESRFTFDLVADENVSQEQMFKVAGVPMVENVVAGYNSCMFAYGQTGSGKTHTMLGDIEGGTRRHSVNCGMTPRVFEYLFSRIQKEKEVRKEEKLHFTCRCSFLEIYNEQILDLLDPSSYNLQLREDHKKGIHVENLKEIEVSSARDVIQQLMQGAANRKVAATNMNRASSRSHSVFTCIIESKWVSQGVTHHRFARLNLVDLAGSERQKSSGAEGERLKEATNINKSLSTLGLVIMNLVSVSNGKSVHVPYRDSKLTFLLQDSLGGNSKTIIIANISPSSSCSLETLSTLKFAQRAKLIKNNAIVNEDASGDVIAMRLQIQQLKKEVTRLRGMGGVDNQDMDTISMGCPASPMSLKWDGFNGSFTPLTTHKRMSKVKDYEVALVGAFRREREKDVALQALTAENEASMKLEKKREDEIRGLKMMLKLRDSAIKSLQGVTSGKIPVEAHLQKEKGDLMKEIEVLRAQVDRNQEVTKFATENLRLKEEIRRLKSQGEEGERDILNQQIQALQAKLLEALDWKLMHESDSSMVKEDGNISNMFCSNQNQESKKLSSIQDENEFLRMQAIQNRAEMESLQKSLSFSLDEKERLQKLVDNLSNELEGKIRSSGMVGDDDQMEVKTMVQAIACVSQREAEAHETAIKLSKENDDLRQKIKVLIEDNNKLIELYEQVAEENSSRAWGKIETDSSSNNADAQNSAEIALEVEKSAAEEQKKMIGNLENQLTEMHDENEKLMSLYENAMKEKDELKRLLSSPDQKKPIEANSDTEMELCNISSEKSTEDLNSAKLKLELAQEKLSISAKTIGVFSSLEENILDIIKLSKESKETEEKVKEHQSELGSIKTVSDQTNARKEVAEKKLAALRCSLSNFASSAVYFQQREERARAHVNSFSGYLNQKNEELDVIRSHKREIDAAMGKIQQSEAELKSNIVMLKIKVDEENKRHEEEGVLCTIDNILRTGKATDLLKSQEEKTKLQSEMKLSREKLASVRKEVDDMTKKSLKLEKEIKTMETEIEKSSKTRTESEMELENTIQEKQTIQEMEEQGMSEIQNMIIEIHQLVFESDLRKEEAMIIREELIAEELRAKDVHTNMIERVENALKTLENQNNSVSGKIEEEVENVLSLVHEASRLLEVSH
What are the official names of this protein?
Kinesin-like protein KIN-12E.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.
Protein: LOLA_COXB1
Sequence: MNTIKILIGLLGIFLFSLSGIVSAQSDATTQLSQLLSNFRTYQAKFNQITFDGQDRVIQQSHGRVMIMRPGRFRWETDSPTKQIIITNGKTLWVYDVDLSQATQQPLAQKTNINPASLLSGSVKDLKQKFTITISPTSDAATFQLVPRLGKSLNFNWIRLKFSKKQLTEMTVLNNLDERSIFQFSQIKVNAPLSSTLFEFKPSRGIDVVKQ
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RL28_RICM5
Sequence: MSRKCELTGVGVLYGNNVSHSQRKTRRRFEPNLRSVKFTSDITAGEYRLSVNARCISSVEKAGGFDAYILKADDNVLSSNARAIKKKIIQTKTAKSL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: TRUD_ANADF
Sequence: MTDAPLVTAELPGSGGSLRRSPEDFRVDEVPAYLPSGAGPHLYLRVEKRGRTTRDALRTLARALGVPERDAGYAGLKDKDAVTTQWLSFPAARDPEPQALASEGLRVLEVSRHANKLRPGHVRANRFQLAVRGGDLARAQAAAAALAERGLPNLFGPQRFGTEGRNAEVGRALLLGDPSPEARRAARDRFLRRLSISAYQALLFNRWLAERMADGLFATAVAGDVLKKLDTGGLFTCADPAVDGPRVQRFEVSPAGPMFGHKLRAAEGEALAREERLLAAEGIQLSDFARGGGEAEGTRRAARLRVEVALAPLEDGYLATFELPKGSYATVVMRELMKAGAELPEADED
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: CNGC6_ARATH
Sequence: MFDTCGPKGVKSQVISGQRENFVRLDSMDSRYSQSSETGLNKCTLNIQGGPKRFAQGSKASSGSFKKGFRKGSEGLWSIGRSIGLGVSRAVFPEDLEVSEKKIFDPQDKFLLLCNKLFVASCILAVSVDPLFLYLPFINDKAKCVGIDRKLAIIVTTIRTVIDSFYLFHMALRFRTAYVAPSSRVFGRGELVIDPAQIAKRYLQQYFIIDLLSVLPVPQIIVWRFLYTSRGANVLATKQALRYIVLVQYIPRFLRMYPLSSELKRTAGVFAETAWAGAAYYLLLYMLASHIVGALWYLLALERNNDCWSKACHNNQNCTRNFLFCGNQNMKGYAAWDNIKVSYLQLKCPVNVPEDEEPPFDFGIYLRALSSGIVSSKNFVSKYFFCLWWGLQNLSTLGQGLETSTYPGEVIFSITLAIAGLLLFALLIGNMQTYLQSLTIRLEEMRVKRRDSEQWMHHRMLPPELRERVRRYDQYKWLETRGVDEENLVQNLPKDLRRDIKRHLCLALVRRVPLFENMDERLLDAICERLKPCLFTEKSYLVREGDPVNEMLFIIRGRLESVTTDGGRSGFYNRSLLKEGDFCGDELLTWALDPKSGSNLPSSTRTVKALTEVEAFALIADELKFVASQFRRLHSRQVQHTFRFYSQQWRTWAACFMQAAWRRYIKRKKLEQLRKEEEEEEAAAASVIAGGSPYSIRATFLASKFAANALRSVHKNRTAKSTLLLSSTKELVKFQKPPEPDFSAEDH
What is the function of this protein?
Probable cyclic nucleotide-gated ion channel.
What are the official names of this protein?
Probable cyclic nucleotide-gated ion channel 6, AtCNGC6, Cyclic nucleotide- and calmodulin-regulated ion channel 6.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DISA_MYCBO
Sequence: MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYHANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSALSPRGYRAMAGIPRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVRDGLSQLAESTISDQ
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: CSN6_PONAB
Sequence: MAAAAAAAAAATNGTGGSSGMEVDAAVVPSVMASGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity).  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity).  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).  Has some glucocorticoid receptor-responsive activity (By similarity).  Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 6, SGN6, Signalosome subunit 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRPG_CORGL
Sequence: MTHVVLIDNHDSFVYNLVDAFAVAGYKCTVFRNTVPVETILAANPDLICLSPGPGYPADAGNMMALIERTLGQIPLLGICLGYQALIEYHGGKVEPCGPVHGTTDNMILTDAGVQSPVFAGLATDVEPDHPEIPGRKVPIGRYHSLGCVVAPDGIESLGTCSSEIGDVIMAARTTDGKAIGLQFHPESVLSPTGPVILSRCVEQLLAN
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 2, AS, ASII, Anthranilate synthase, GATase component, Anthranilate synthase, glutamine amidotransferase component.
Protein: TPIS_CULTA
Sequence: MGRKFCVGGNWKMNGDKASIADLCKVLTTGPLNADTEVVVGCPAPYLTLARSQLPDSVCVAAQNCYKVPKGAFTGEISPAMLKDLNIGWVILGHSERRAIFGESDELIADKVAHALAEGLKVIACIGETLQEREAGQTEAVCFRQTKAIADKVKDWSNVVIAYEPVWAIGTGKTASPEQAQEVHAALRKWFTENVSADVSAAIRIQYGGSVTAANCRELAAKPDIDGFLVGGASLKPEFIQIVNARQ
What are the official names of this protein?
Triosephosphate isomerase, TIM, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
Protein: LHB1_HALHL
Sequence: ADNMSLTGLSDEEAKEFHSIFMQSFLIFTAVAVVAHFLAWAWRPWIPGAEGYG
What is the function of this protein?
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
What are the official names of this protein?
Light-harvesting protein B800/850/890 beta-1 chain, Antenna pigment protein beta-1 chain, EHA-beta-1.
What is the protein family that this protein belongs to?
Belongs to the antenna complex beta subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: TOIP1_PONAB
Sequence: MAGEGRRAEAVREGWGVYVTPRAPIREGRGRLAPQNGGSSDAPAYRTSLSRQGRREVRFSDEPPEVYGDFEPLVDKERSPVGKRTRLEEFRSDSAKEEVRESAYYLRSRQRRQPRPQEAEEMKTRRTTRLQQQHSQQPPLQPSPVMTRRGLRDSHSSEEDEPSSPTDLSQTISKKTVRSIQEAPAESEDLVISLRRPPLRYPRSEATSVQQKVNFSEEGETEDDQDSSHSSVTTVKSRSRDSDESGDKTTRSSSQYIESFWQSSQSQNFTAHDKQPSVLSSGYQKTPQEWAPQTARMRTRMQTSSPGKSSIYGSFSDDDSILKSELGNQSPSTSSQQVTGQPQNASFVKRNWWWLLPLIAALASGSFWFFSTPEVETTAVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILLLTAARDAEEALRCLSEQIADAYSSFHSVRAIRIDGTDKATQDSDTVKLEVDQELSNGLKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLGTSLGLKEVEEKVRDFLKVKFTNSNTPNSYNHMDPDKLNGLWSRISHLVLPVQPENALKRGICL
What is the function of this protein?
Required for nuclear membrane integrity.  Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane.  Binds to A- and B-type lamins.  Possible role in membrane attachment and assembly of the nuclear lamina (By similarity).
What are the official names of this protein?
Torsin-1A-interacting protein 1, Lamina-associated polypeptide 1B, LAP1B.
What is the protein family that this protein belongs to?
Belongs to the TOR1AIP family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass membrane protein.
Protein: PRVB3_MERAP
Sequence: AFAGVLADADIKAALAGCAAADSFNYKTFFKSPEEVKKFFAIIDQDHSGFIEEEELKLFLQTFSAGARALSDAETK
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin beta 3.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: MURB_RHIEC
Sequence: MKQVNGEKLLASLGDGVKDIRGRITPDAPMDRVTWFRAGGLAELMFQPHDIDDLIAFLKILPEEVPLTVIGVGSNILVRDGGIPGVVLRLSAKGFGFVELAGENRILAGAICPDKHVAAMAMDNGIGGLHFYYGIPGAIGGAARMNAGANGVETRERLIEVNAVDRKGNKHVLSNAEMGYSYRHSAAPTDLIFTSVLFEGYPEDRAQIRAEMDAVRNHRETVQPVREKTGGSTFKNPPGHSAWKLIDEAGCRGLVIGGAQMSSLHCNFMINMGQATGYDLEYLGEQVRREVFEKEGIKLEWEIKRLGVFMPGREVRPFQGVTSE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDX5_MOUSE
Sequence: MSSYSSDRDRGRDRGFGAPRFGGSRTGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVDTYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSNLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVANMHNGMNQQAYAYPLPQAAPMIGYPMPTGYSQ
What is the function of this protein?
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner.  Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10.  The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.  Involved in transcriptional regulation; the function is independent of the RNA helicase activity.  Transcriptional coactivator for androgen receptor AR but probably not ESR1.  Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation.  Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis.  Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation.  Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1.  As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX5, DEAD box RNA helicase DEAD1, mDEAD1, DEAD box protein 5, RNA helicase p68.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Cytoplasm. Note=During the G0 phase, predominantly located in the nucleus. Cytoplasmic levels increase during the G1/S phase. During the M phase, located at the vicinity of the condensed chromosomes. At G1, localizes in the cytoplasm.
Protein: DPHB_THEKO
Sequence: MVLYFIGLGLYDEKDITLKGLETARRCDKVFAEFYTSLLAGTTLEKIEELIGKPIVRLSREDVELNFERIVLPEAKDKDVAFLTAGDPMVATTHSDLRIRAKKAGVKSYVIHAPSIYSAVAITGLQIYKFGKSATVAYPEKNWFPTSHYDVIRDNKERGLHTLLFLDIKADQNRYMTANEAMEILLKVEEMKGEGVFTPETLVVVLARAGSLEPTLRAGYVRELINEDFGRQPHVLIVPGRLHIVEAEYLVEFAGAPEKILEEV
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: PROA_BARQU
Sequence: MKDMGQKARHAAALLAVMSSEQKNKALEMIALSLEAQSAEILQANHQDLVNAAQNNLNVAMVDRLKLDKVRLCTIIDSVRQVACLPDPVGQVMSEWTRPNGLHIRRVRTPLGVIGIIYESRPSVTIDASILCLKSGNAAILRGGSDSFHSAHALHSALVKGLKEAGLPQDAIQMVGTKDRDVVGEMLKGLDGAIDVIVPRGGKDLVARVQSDARVPIFAHLEGLCHIYIDQSADLDMARNIVLNAKLRRTGICGAVETVLIDRQALKKFLPVLTALQEKGCEIRATEDIVFLLPDVKLASEEDWSQEYLDAILSVKTVEGIEGAIAHIRRYSSGHTESIIAEDMKVVKIFFNCLDSAILLHNASTQFADGGEFGFGAEIGIATGKMHARGPVGVEQLTSFQYHVKGNGQVRS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAB_PHOPR
Sequence: MSYAELIEEQKEETRDIIAALLEDGSEPEALYTIEHHFSADTFAELEAAAVEAFKMGFEVLEAEELELAPEDGGGKVVCFDAVMESALNAELIDEQTEKLIALADKHDIDYDGWGTYFESDEDDEEDESEDKPEA
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity B.
What is the protein family that this protein belongs to?
Belongs to the RraB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2M1_METJA
Sequence: MVKLMKKLEDKKGIIEITFEEEREILELPSKPELPKYASQLINLANIFSQGTRPKVVGQMSELIKEFRKTGGRTFEDWKKWYLQKYPNAIDEATEKIWNMLNNFKETLEQLERDDVRKWVEDLVLIKTYEGLMLQDAILKKVAEELGGNYRPSTIEEESKGIDGVIIIDDKEIPVSIKSKTYVNQEKHLSEELKGHLIIYEKKKNKIIVDYSDLLDLVENTK
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-CTAG-3'; the cleavage site is unknown.
What are the official names of this protein?
Type II restriction enzyme MjaI, R.MjaI, Endonuclease MjaI, Type-2 restriction enzyme MjaI.
Protein: NU4LM_BERBI
Sequence: MSLIYMNVMMAFTMSLTGLLMYRSHLMSALLCMEGMMLSLFILAALTILNSHFTLANMAPIILLVFAACEAAIGLALLVMISNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SEP2_ARATH
Sequence: MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVSLIVFSNRGKLYEFCSTSNMLKTLERYQKCSYGSIEVNNKPAKELENSYREYLKLKGRYENLQRQQRNLLGEDLGPLNSKELEQLERQLDGSLKQVRCIKTQYMLDQLSDLQGKEHILLDANRALSMKLEDMIGVRHHHIGGGWEGGDQQNIAYGHPQAHSQGLYQSLECDPTLQIGYSHPVCSEQMAVTVQGQSQQGNGYIPGWML
What is the function of this protein?
Probable transcription factor.  Functions with SEPALLATA1/AGL2 and SEPALLATA3/AGL9 to ensure proper development of petals, stamens and carpels and to prevent the indeterminate growth of the flower meristem.  Forms a heterodimer via the K-box domain with AG, that could be involved in genes regulation during floral meristem development.
What are the official names of this protein?
Developmental protein SEPALLATA 2, Agamous-like MADS-box protein AGL4.
What are the subcellular locations of this protein?
Nucleus.