PharMolix/UniProtQA huggingface dataset:
Protein: LPXF_BACTN
Sequence: MIEFLSDIDTQLLLFFNGIHSPFWDYFMSAFTGKVIWVPMYASILYILLKNFHWKVALCYVVAIALTITFADQMCNSFLRPLVGRLRPSNPENPIADLVYIVNGRRGGGFGFPSCHAANSFGLAIFLICLFRKRWLSIFIVLWAFTNSYTRLYLGLHYPGDLVAGAIIGGFGGWLFYFIAHKLTARLQSDTPVPGKGAGMKQTEVMIYTGLLTLAGIIIYSIVQS
What is the function of this protein?
Probably removes the 4'-phosphate group from lipid A.  Removal of this phosphate group confers resistance to cationic antimicrobial peptides (CAMPs), inflammation-associated peptides produced by the human host.  This LPS modification helps maintain the stability of this commensal bacterium in gut microbiota.
What are the official names of this protein?
Lipid A 4'-phosphatase.
What is the protein family that this protein belongs to?
Belongs to the lipid A LpxF 4'-phosphatase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SC5AB_PIG
Sequence: MESSPSSPQPTQSDPLAVFPQRTLEPADIAVLVLYFLFVLAVGLWSTVKTRRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFVGLAGSGAAAGLSVTAYEFNGIFSVLMLAWIFLPIYIAGQVTTMPEYLRKRFGGSRIPITLAVLYLFIYIFTKISVDMYAGAIFIQQSLHLNLYLAIVGLLAITALYTIAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSGNSSCGLPREDAFHIFRDPLTSDLPWPGILFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGSLMAAYLKVLPLFIMVFPGMVSRVLFPDQVACADPEICQKVCSNPAGCSDIAYPKLVLELLPMGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHLRPRASERELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFSGLILGLLLGLVRLVLDFIYPQPRCDQPDERPAVVRDVHYLYFSMILSSVTLVTVSTVSWCTAPPTQEMVSRLTWFTRHDPIVLKEQVPSATPVPVTVSQNGTPEASSTNIQFEIVQENTSKTHSCDMTKKQSKVVKTILWLCGMESKGKEEPPSRADPVIVSLEEIPLVKTLLDINLIVCISCAIFLWGYFA
What is the function of this protein?
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1.  Exclusively responsible for apical MI transport and absorption in intestine.  Can also transport D-chiro-inositol (DCI) but not L-fucose (By similarity).  Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity).  May induce apoptosis through the TNF-alpha, PDCD1 pathway (By similarity).  May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity).
What are the official names of this protein?
Sodium/myo-inositol cotransporter 2, Na(+)/myo-inositol cotransporter 2, Sodium/myo-inositol transporter 2, SMIT2, Solute carrier family 5 member 11.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: FUS_MUMPS
Sequence: MKAFPVICLGFAIFSSSICVNINILQQIGYIKQQVRQLSYYSQSSSSYVVVKLLPNIQPTDNSCEFKSVTQYNKTLSNLLLPIAENINNITSPSPGSRRHKRFAGIAIGIAALGVATAAQVTAAVSLVQAQTNARAIAAMKNSIQATNRAVFEVKEGTQQLAIAVQAIQDHINTIMNTQLNNMSCQILDNQLATSLGLYLTELTTVFRPQLINPALSPISIQALRSLLGSMTPAVVQATLSTSISAAEILSAGLMEGQIVSVLLDEMQMIVKINVPTIVTQSNALVIDFYSISSFINNQESIIQLPDRILEIGNEQWRYPAKNCKLTRHHIFCQYNEAERLSLETKLSVAGNISACVFSSIAGSYMRRFVALDGTIVANCRSLTCLCKSPSYPIYQPDHHAVTTIDLTSCQTLSLDGLDFSIVSLSNITYAENLTISLSQTINTQPIDISTELSKVNASLQNAVKYIKESNHQLQSVSVSSKIGAIIVAALVLSILSIIISLLFCFWAYIATKEIRRINFKTNHINTISSSVDDLIRY
What is the function of this protein?
Class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes.  Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm.  This fusion is pH independent and occurs directly at the outer cell membrane.  The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface.  Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes.  Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
What are the official names of this protein?
Fusion glycoprotein F0.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses fusion glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: PYRG_TROWT
Sequence: MNGIKHIFITGGVVSSIGKGLTAASLGSLLTMRGLKVFIKKLDPYLNVDPGTMNPLQHGEVFITEDGAETDLDVGHYERFLDVDLDRTANVTTGQVYSKVITLERTGRYLGETVQVIPHITDEIKRRIRLAPDDIDVIITEIGGTVGDIESQPFIEAARQIRREVGRENCCFIHVSLVPFLESAGEQKTKPTQHSVAILRAAGIQPDALVLRSDKPISSANQKKIALMCDVSAVVNAVTVPNIYEIPCVLNQHGLDKFVIKHLDLEAGEIDWSYWDDVLDAIENNRSEIEIAIIGKYTGLPDAYISVIEALRAGGFESKTKVNIKWVDSDDENLEDQLENINGACIPGGFGIRGIEGLIKAIRICREREIPTLGICLGMQCMVIEYARHVVGMHGASSTEFTDDTQWPVVTTMLEQRDILIDDQFGGTMRLGSYRAVLSIGSLAASLYGTTDIHERHRHRYEVNNGYAQRLVERGLIVSGRNTEQDLIEFIELDRKDHPFYIGTQAHPECKSRPKRPHPLFKGLVAAALARKEIAEFNSGKTVLQ
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ILK1_ARATH
Sequence: MENITAQLKRGISRQFSTGSIRRTLSRQFTRQSSLDPRRTNMRFSFGRQSSLDPIRRSPDSSKSDDEPHMSVPENLDSTMQLLFMASKGDVRGIEELLDEGIDVNSIDLDGRTALHIAACEGHLGVVKALLSRRANIDARDRWGSTAAADAKYYGNLDVYNLLKARGAKVPKTRKTPMTVSNPREVPEYELNPLEVQVRKSDGISKGAYQVAKWNGTRVSVKILDKDSYSDPERINAFRHELTLLEKVRHPNVIQFVGAVTQNIPMMIVVEYNPKGDLSVYLQKKGRLSPSKALRFALDIARGMNYLHECKPDPIIHCDLKPKNILLDRGGQLKISGFGMIRLSKISQDKAKVANHKAHIDLSNYYIAPEVYKDEIFDLRVDAHSFGVILYEITEGVPVFHPRPPEEVARMMCLEGKRPVFKTKSRSYPPDIKELIEKCWHPEAGIRPTFSEIIIRLDKIVANCSKQGWWKDTFKFPWK
What is the function of this protein?
Functions as a link between plant defense pathways, stress responses and potassium homeostasis.  Promotes osmotic stress sensitivity, responses to the bacterial-derived pathogen-associated molecular pattern (PAMP) flg22, and resistance to bacterial pathogens.  Promotes the accumulation of POT5/HAK5, a potassium transporter that mediates high-affinity uptake during potassium deficiency.
What are the official names of this protein?
Integrin-linked protein kinase 1, Ankyrin protein kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: LPLT_YERPP
Sequence: MSQDVLADKPLLSRSMVAVLCAQFFSAFGDNALLFATLALIKQQLYPDWSQPILQMAFVATYIVLAPFVGQIADGFAKGRVMMVANGLKLAGALVICFGLNPFLGYSLVGVGAAAYSPAKYGILGEITSGEQLVKANGMMEASTIAAILLGSVAGGILADWHLMAALGVCALVYAIAVIANLFIPRLAAARSGASWRPRAMTGSFFTACRLLWQDSETRFSLAGTSLFWGAGVTLRFLLVLWVPVALGIADNATPTLLNAMVAIGIVVGAGAAARFVTLKTVKRCLPAGVLIGVMVTIFSLQNSMPMAYLLLIIIGILGGFFVVPLNALLQERGKHSVGAGNAIAVQNLGENTAMLFMLGLYSLVVKLGAPVVAVGVGFGVVFALAIALLWGWQWRQQRQKTRQPE
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RRF_HALH5
Sequence: MSKEVLNDAEQRMTKATEALGRELAKLRAGRANPAMLDRITVEYYGAETPLNQLATISVPEARLLVIQPFDKSSISDIERAIQKSDLGLTPSNDGTVIRITIPPLTEERRRDLTKLVKKSAEEAKVAVRNIRRDANDDLKKRQKDGELTEDDLRRVTEDVQKLTDKYIEQIDQKAEAKEKEIMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
Protein: DAA1A_XENLA
Sequence: MAPRKRNSRGVSFIFCCFRSSEHPEITYRLRNDSNFALQSMEPALPVPPVEELDAMFAELVDELDLSEKHREAMFALSAEKKWQIYCSKKKDHEEGATSWPEFYIDQLNSMAARRTLFAMDKEDEEERNKTIESLKTALRTKPMRFVTRFIDLDGLTCILNFLKSMDYEIAESQIHTSLIGCIKALMNNSQGRAHVLAHTESINVIAQSLATENIKTKVAVLEIMGAVCLVPGGHKKVLEAMLHYQRYASERTRFQTLINDLDRSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFDLVHIDTKSATQMFELIRKRLTHTESYPHFTSILHHCLQMPYKRSGNTVHYWLLLDRIVQQIVIQNEKGQDPDTSPLENFNVKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEYKNVKQQVAELTAQIQELNSRTVCAPGPGGPPPPPGAPGGPMSMPSGNFMPPPPPPPPPFPGGMAPPPPPPPPPPPPPGGPPPPPGLPLLGAAPPGAPLGLSMKKKNIPQPKNPLKSFNWSKLPDNKLEGTLWIDLDDAKVLKILDLEDIERTFSAYQRQQDFFVNNGIKQKEMDCTDDTLSSKMKVKELSVVDGRRAQNCNILLSRLKLTNEEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRDASKEVLQSKNLKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITVVEKKYPKIVNLHEELQTISVAAKVNMTELEKEISALRNGLKSVENELEYQKTQPTLPGDKFVSVVSQFITVAGFSFCDVEDLLSEAKELFVKSAKRFGEETNKIQPDEFFGIFDQFLQAFLEAKQENENIRKRKEEEERRIRMEAQLKEQRERERKARKAKENGEEEGEFDDLVSALRSGEVFDKDLSKLKRNRKRIVSQTTESSRERPVTKLNY
What is the function of this protein?
Binds to disheveled (dsh) and Rho, and mediates Wnt-induced dsh-Rho complex formation during gastrulation (PubMed:11779461).  May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation.  Can direct nucleation and elongation of new actin filaments.  Involved in building functional cilia (By similarity).  Involved in building functional cilia.  Involved in the organization of the subapical actin network in multiciliated epithelial cells (PubMed:26644512).
What are the official names of this protein?
Disheveled-associated activator of morphogenesis 1-A.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body.
Protein: PDXJ_RHOPT
Sequence: MSKAPPLRLGVNIDHIATLRNARGGRHPDPLRAAFAAIEAGADGITAHLREDRRHIRDADMQRLKAEISKPLNFEMAATDDMIRIALGVKPHAVCLVPERREELTTEGGLDVVGQQASLGPAIARFNDAGIRTSLFIAADPAQIETAAKLKAPAIEIHTGAWCDAITDGDAAKANTEWQRIFAGAALARSAGLEVHAGHGLDYATAETISELPQIVELNIGFHMIGEALFVGLGETVRAMRAAMDRGRAKAIAA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_CLOAB
Sequence: MKLIREFYSRDTIVVAKELLGKVLVHEVNGIRTSGKIVEVEAYRGINDKGAHAYGGRRTPRTEALYGPAGHAYVYFIYGLYYCMNVVAMQEGIPEGVLIRAIEPIEGIEVMSERRFKKLFNDLTKYQLKNLTNGPSKLCSAMEIRREQNLMDLNGDELYIEEGKNESFEIVEAKRVGIDYAEEAKDYLWRFYIKGNKCVSVLKKD
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: TRPF_NITMU
Sequence: MSIRVKVCGITRVEDALAAVHLGANAVGFVFWEQSARYISPAEARGIVSTLPPFVTSVGVYVDPEAGWVDESISVAGLNLLQFHGSESPEFCQQFSLPYIKAVRVRPGLDLLQYASLYTGATGLLLDTYVEGEPGGTGEAFDWNLIPRNLPLPLILSGGLHAGNVTSAIQQAHPWAVDVSSGVEAAKGIKDSGKIAAFMRGVGISESL
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: LSPA_TERTT
Sequence: MHKLNVLAALKWYGVALLVILLDQITKNVASHMLVLHQPEPITSFFNFTLRHNFGAAFSMFHDAGGWQRWFLALLAAGVSVLLIFWIAKLPKQKWMEALALALVLGGALGNLYDRMLLGYVVDFIVVHYKEHEWPAFNIADSAICIGAALLVWDSLFGTKVAKYGDAK
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PR1_HORVU
Sequence: MQTPKLAILLALAMAAAMVNLSQAQNSPQDYVSPHNAARSAVGVGAVSWSTKLQAFAQNYANQRINDCKLQHSGGPYGENIFWGSAGADWKASDAVNSWVSEKKDYDYGSNTCAAGKVCGHYTQVVWRASTSIGCARVVCNNNRGVFITCNYEPRGNIIGQKPY
What is the function of this protein?
Probably involved in the defense reaction of plants against pathogens.
What are the official names of this protein?
Pathogenesis-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
Protein: RECF_LACLA
Sequence: MKLKAIELKNFRNYEELKLDFHPNLNIFLGQNAQGKTNILEAIHFLALTRSHRTSHDKELISWSQQEMKVSGVVEKAHATVPLEVQLSPKGRIAKANHLKENRLADYIGQLKILMFAPENLELVKGSPATRRKFMDIELGQIHAVYLYDSMRYNRALKERNAYLKFDKDKIDKNFLSVLDGQLAEHGNKIMLERQNFIDKLEVHAKKIHEQLTHGKENLKIIYNQNVKTDFSKELLSRQDHDIFRHQTSVGPHRDDLQFFINEINVADFGSQGQQRTVALSIKLAEIDLIFEETGEYPILLLDDVMSELDNHRQLDLIETSLGKTQTFITTTTLDHLKNLPENLSIFHVNAGTIEQEQ
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP (By similarity).
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PACC_PENCH
Sequence: MTENHTPSTTQPTLPAPVAEAAPIQANPAPSASVTATAAAATAAVNNAPSMNGAGEQLPCQWVGCTEKSPTAESLYEHVCERHVGRKSTNNLNLTCQWGTCNTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSEIRSPEPGMKHPDMMFPQNPRGSPAATHYFESPINGINGQYSHAPPPQYYQPHPPPQAPNPHSYGNLYYALSQGQEGGHPYDRKRGYDALNEFFGDLKRRQFDPNSYAAVGQRLLGLQALQLPFLSGPAPEYQQMPAPVAVGGGGGGYGGGAPQPPGYHLPPMSNVRTKNDLINIDQFLEQMQNTIYESDENVAAAGVAQPGAHYVHGGMNHRTTHSPPTHSRQATLLQLPSAPMAAATAHSPSVGTPALTPPSSAQSYTSNRSPISLHSSRVSPPHEEAAPGMYPRLPAAICADSMTAGYPTASGAAPPSTLSGAYDHDDRRRYTGGTLQRARPAERAATEDRMDISQDSKHDGERTPKAMHISASLIDPALSGTSSDPEQESAKRTAATATEVAERDVNVAWVEKVRLLENLRRLVSGLLEAGSLTPEYGVQTSSASPTPGLDAMEGVETASVRAASEQAREEPKSESEGVFYPTLRGVDEDEDGDSKMPE
What is the function of this protein?
Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH.  At alkaline ambient pH, activates transcription of alkaline-expressed genes (including PACC itself) and represses transcription of acid-expressed genes.  Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'.
What are the official names of this protein?
pH-response transcription factor pacC/RIM101.
What is the protein family that this protein belongs to?
Belongs to the pacC/RIM101 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YOHO_ECOL5
Sequence: MRIAKIGVIALFLFMALGGIGGVMLAGYTFILRAG
What are the official names of this protein?
UPF0387 membrane protein YohO.
What is the protein family that this protein belongs to?
Belongs to the UPF0387 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YCJV_ECOUT
Sequence: MAQLSLQHIQKIYDNQVHVVKDFNLEIVDKEFIVFVGPSGCGKSTTLRMIAGLEEISGGDLLIDGKRMNDVPAKARNIAMVFQNYALYPHMTVYDNMAFGLKMQKIAREVIDERVNWAAQILGLREYLKRKPGALSGGQRQRVALGRAIVREAGVFLMDEPLSNLDAKLRVQMRAEISKLHQKLNTTMIYVTHDQTEAMTMATRIVIMKDGIVQQVGAPKTVYNQPANMFVAGFIGSPAMNFIRGTIDGDKFVTETLKLTIPEEKLAVLKTQESLHKPIVMGIRPEDIHPDAQEENNISAKISVAELTGAEFMLYTTVGGHELVVRAGALNDYHAGENITIHFDMTKCHFFDAETEIAIC
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YcjV.
Protein: UBIG_BURA4
Sequence: MTNADPHELQKFSDLAHRWWDPNAEFKPLHELNPVRLGWIDAHAHLAGKRALDIGCGGGILSESMAGLGAQVKGIDLSTEALGVADLHSLESGVTVDYEAIAAEALAEREPGTYDVVTCMEMLEHVPSPAGIVSACATLVKPGGWVFFSTLNRNLKSYLFAVIGAEYIARMLPKGTHDYARFIRPSELASFVRGTDLHIVEIKGITYHPIGKRFALSNDTDINYLVACRRGA
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: TGT_SOLM1
Sequence: MNAPGTFTLGPGDGSARTARLTTAHGEIETPVFMPVGTQGTVKSLCPTDLQDIKARIILGNTYHLYLRPGDELVAKLGGLHRFMGWDGPILTDSGGFQVFSLSGLRRITEEGVTFASHIDGSKHLFSPEKVVSIQRNLGSDIMMVLDECVPYGADRAYTEKSLGLTTRWARRCRKAHPAGDRGQLMFGIVQGGFFKDLRAQSAEQIIEVGFDGYALGGLSVGESRAEMYDILGDAAPLLPADRPRYLMGVGAPRDLLAGMAAGIDMFDCVLPTRNARNGTLFTFQGKVNIKRAEYREDDSPLDPTCPCYACRTFSRAYLRHLYIAKELLSYRLNTLHNLTFFSIMMERARQAIREGRFAAYRAEMEALYPEGE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SYDP_SHEPC
Sequence: MSCLPALDKFLQNYHQAYLTTLGELPRYYPQGEPSVCIQGEFFADSDKPIAWQPVKRDEVGSFTNVEHALDLPLWPDIHLFYGQYFSAPLLFDSKWGTGELLQVWNDDDFKCLQQNVIGHLMMKKKLKQPPTWFIGLLDEGDKMLTINNSDGSVWIEIPGEEQSEQLSTSLTAFIEALSPRIAPPVKHEELPMPALDHPGIFANIKRMWQNLFGKS
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: YM14A_YEAST
Sequence: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY
What is the function of this protein?
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.  The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules.  CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
What are the official names of this protein?
Transposon Ty1-MR2 Gag polyprotein, Gag-p49, Transposon Ty1 protein A, TY1A, TYA, p58.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YRZE_BACSU
Sequence: MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAMLLTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSFSLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST
What are the official names of this protein?
Uncharacterized membrane protein YrzE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURQ_SYNP2
Sequence: MNSYESRGHLLTEQVNPQSQNLDQMSALELVDLFNQEDQKTLEAIANAREALAQAIEITSEALMHGGRLFYVGAGTSGRLGVLDAAECPPTFCTPPELVQGIIAGGAGALVRSSEDLEDRAEDGKKAIAQRQITELDVVVGITAGGTTPYVQGALIAAQQRGAKTIFISCVPAEQVPFAAAVDIRLLTGPEILAGSTRLKAGTVTKMALNILSTSVMVKLGKVYGNRMIDVAVTNHKLHDRALRILQDLTDLSREEAAILLEKSQRRVKIALLMHWKNVDASEAEHLLKVHQGSLRTALKS
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: TRHO_SINMW
Sequence: MTDMLTTSRRPETPGQFLVAALYHFISFPRFADFREPLQAICDANGVKGTLLLAHEGINGTIAGSEEGIATVLAFLRAQPEFADLVHKESRASAMPFLRMKVRLKKEIVTMGVENIDPKKVVGTYVEPKDWNALISDPETLVIDTRNDYETAIGVFQGAVDPKTKTFREFPEWVRNNSGLHNKPKIAMYCTGGIRCEKATAFMKEQGFEEVYHLKGGILKYLEEIPPEESLWEGACFVFDERVSVTHGLQEGEHTLCHACRQPLTTEDLRSPLHEEGVSCVNCHDTRTEEDRERYRQRQRQIVLAKKRGARHLGS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: UPP_CORA7
Sequence: MDIHVVDHPLAASRLTLMRDARSDNTAFRAALRDLGTMLVYEAARDLPVEHFDCVTPVATAEGTRLQNPPIIVPIIRAGLGMIDPALSMIPDAQVGFIGMARDEETHEPVPYLEALPEDLSGRSVFVVDPMLATGGSLLHSLKLLADRGATDITAICMVSAQPGVDALANSGLPVRLVTAAIDPALNEDAYIVPGLGDAGDRLYGPRNIDL
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: AROB_STAAS
Sequence: MKLQTTYPSNNYPIYVERGAIDHISTYIDQFDQSFILIDEYVNQYFANKFDDILSYENVHKVIIPAGEKTKTFHQYQETLEYILSHHVTRNTAIIAVGGGATGDFAGFVAATLLRGVHFIQVPTTILAHDSSVGGKVGINSKQGKNLIGAFYRPTAVIYDLDFLKTLPFEQILSGYAEVYKHALLNGESTTQEIEQHFKDREILQSLNGMDKYIAKGIETKLDIVVADEKEQGVRKFLNLGHTFGHAVEYYHKIPHGHAVMVGIIYQFIVANALFDSKHEINHYIQYLIQLGYPLDMITDLDFETLYEYMLSDKKNDKQGVQMVLIRQFGDIVVQHVDQLTLQHACEQLKTYFK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.