PharMolix/UniProtQA huggingface dataset:
Protein: RECK_MOUSE
Sequence: MASVRASPRSALLLLLAAAGVAEVTGGLAPGSAGAVCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWSCMNSSLPGVFKKSDGWVGLGCCELAIGLECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREFCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRICEYNPVEVSMLTCLADVREPCQLGCTNLTYCTNFNNRPTELFRSCTAQSDQGAMSDMKLWEKGSIKMPFISIPVLDIKTCQPEMWKAVACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEEHTAESICEFLSPADDLESCIPLDTYLRPSALGNIIEEVTHPCNPNPCPANELCEVNRKGCPSADPCLPYSCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFTIDCNVCSCFAGNLVCSTRLCLSEHSSDDDRRTFTGLPCNCADQFVPVCAQNGRTYPSACIARCVGLQDHQFEFGPCISKNPCNPNLCPKSQRCVPKPQVCLTTFDKFGCSQYECVPRQLTCDQARDPVCDTDHMEHSNLCTLYQRGKSLSYRGPCQPFCRAKEPVCGHNGETYSSVCAAYSDRVAVDYYGPCQAVGVLSEYSAVAECAAVKCPSLSAIGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTSKKPITVVEILQKVRMHVSVPQCDVFGYLSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSLPSSAVVGRPLFHSLLLLLSLGLTVHLLWTRP
What is the function of this protein?
Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28803732).  Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:26658478, PubMed:28803732).  Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (By similarity).  ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity).  Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:11747814).  Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:11747814).
What are the official names of this protein?
Reversion-inducing cysteine-rich protein with Kazal motifs, mRECK.
What is the protein family that this protein belongs to?
Belongs to the RECK family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: RS7_KOCRD
Sequence: MPRKGPAPKRPLVVDPVYGSPVVTQLINKVLQDGKKSTAERIVYGALEGVRNKTNSDPVATLKKALENVKPALEVRSRRVGGATYQVPVEVKAGRAQALSLRWLVGYSKARRENTMTERLQNEILDASNGLGAAVKRREDTHKMAESNKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: DB119_HYLLA
Sequence: MKLLYLFLAILLAIEEPVISGKHHILRCMGNSGICRASCKKNEQPYLYCRNYQHCCLQSYMRISISGEEENTDWSYEKQWPRLP
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 119, Beta-defensin 120, Defensin, beta 119, Defensin, beta 120.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YCJQ_SHIFL
Sequence: MKKLVATAPRVAALVEYEDRAILANEVKIRVRFGAPKHGTEVVDFRAASPFIDEDFNGEWQMFTPRPADAPRGIEFGKFQLGNMVVGDIIECGSDVTDYAVGDSVCGYGPLSETVIINAVNNYKLRKMPQGSSWKNAVCYNPAQFAMSGVRDANVRVGDFVVVVGLGAIGQIAIQLAKRAGASVVIGVDPIAHRCDIARRHGADFCLNPIGTDVGKEIKTLTGKQGADVIIETSGYADALQSALRGLAYGGTISYVAFAKPFAEGFNLGREAHFNNAKIVFSRACSEPNPDYPRWSRKRIEETCWELLMNGYLNCEDLIDPVVTFANSPESYMQYVDQHPEQSIKMGVTF
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of the hydroxyl group at C3 of D-gulosides leading to 3-dehydro-D-gulosides.  Probably functions in a metabolic pathway that transforms D-gulosides to D-glucosides.  Is also able to catalyze the reverse reactions, i. e.  the NADH-dependent reduction of the oxo group at C3 of 3-dehydro-D-gulosides leading to D-gulosides.  In vitro, can oxidize D-gulose and methyl beta-D-guloside, and reduce methyl alpha-3-dehydro-D-guloside and methyl beta-3-dehydro-D-guloside.  However, the actual specific physiological substrates for this metabolic pathway are unknown.
What are the official names of this protein?
D-guloside 3-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: CLPS_XYLF2
Sequence: MSQKTVHDQDNALLLETGNTKVAPPPRYQVLLLNDDYTPMDFVIVVLQQFFAMDLKKATQVMLHVHTRGRGVCGFYTREVAESKVAQVNEFSRIHQHPLLCTMKQA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: TCPG_PONAB
Sequence: MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMVEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDINDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.  As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.  The TRiC complex plays a role in the folding of actin and tubulin.
What are the official names of this protein?
T-complex protein 1 subunit gamma, TCP-1-gamma, CCT-gamma.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y298_MYCTO
Sequence: MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Antitoxin MT0312.
Protein: MYO16_RAT
Sequence: MEIDQCLLESLPLGQRQRLVRRMRCEQIKAYYEREKVFQKQEGLLKRIKPGKSQKVRFGLADMIQDAIIHHHDKEVLQLLKEGADPHTLVSSGGSLLHLCARYDNVFIAEVLIDRGVNVNHQDEDFWAPMHIACACDNPDIVLLLILAGANVLLQDVNGNIPLDYAVEGTESSAILLAYLDENGVDLNSLRQIKLQRPLSMLTDVRHFLSSGGDVNEKNDDGVTLLHMACASGYKEVVLLLLEHGGDLNGMDDGYWTPLHLAAKYGQTTLVKLLLAHQANPHLVNCNGEKPSDIAASESIEEMLLKAEIAWEERMKESPSVPSLAQEELYEEILHDLPELSSKLSPLVLPIAKQDSLLEKDIMFKDTTKGLCNQESQDGPPETSMVSSSSKPEQVQLTPPAPSDDLATLSELNDSSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTVVSQMYLSPTGQRSPSLPPHLFSCAERAFHRLFQERRPQNIILSGERGSGKTQASKQIMKHLTSRASSSCTMFDSRFKHAICILEAFGHAKTTLNNVSSCLIQYWELQFCQRRKHVTGARISTYMLEKPRLVAQPPGQGSFLIFSWLMDGLSAEEKCGLHLSNFCAHRYVSQGMREDVSTAERSLNKERLADLKHALNVIGFSALEVENLFAILSAILHIGDIQFTALTEADSAFVSDLQLLEQVADMLQVSTDELASALTTDIQYFKGDVIIRRHTTQIAAFYRDLLAKSLYSRLFGFLINTVNCCLQSQDEYKSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPSGFFSLLDEESQAIWSVEPNLPRKLQGLLESSNTNAVYSPMKDGNGNVAFKGQGAAFTVMHYAGRVTYEIRGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSPTGSLISSYPSFKFGGHKSSLLSKRIASSMVGVNKNYLELSKLLKKKGTCTFLQRLERGDPATTASQLTKSLADITAKLQKGSPHFILCVKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRYGYPVRPSFEDFLSRYEPLASVLLGEKKGQPAEERCRLVLQRCKLQGWQMGVHKVFLKYWQVDQLGDLWLQMQRKIVTCQKVIRGFLARQHLLQRMSIKQQEVTSIKSFLQSTEDMALKTYDALVIQNASDIAREHDRLRKEVHAAYHRNRQEEGTKRAEDQGGCRHAHSNSVPVPMAVDSLAQALAGPSSRSPSLHSVFSMDDSTGLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSATKDAASEALTRPRPHSDDYSTMKKIPPRKPKRSPHTKLSGSYEEIWGPRPSGTMGQVGKHHAPGTLGVQWASPDSMPQCTPQLPLHLPLPQGDYDDDGEPVYIEMVGNAARAGGSETDSPDQGESVYEEMKYVLPEEGCGPGMLTFLPASPPLFLETRKAIILEAGEGSCQPLKDTCDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQSEGSSPLSPQYSKAQKGENDQLTSPGFPVFNGPSRISPPATPPPPPGPPPAPCGPPSAPCGPPPAPCGPPPVPCGPPPAPCGPPPAPCGAAPAPCRPPTHFAFPPDSVLVTAAKALTNSDLPRTQPKPSSAPVLGPCSPFVKAPYSPGRTARADLRKASSTFSPPSPYSPPNSRPLSSPLDELASLFNSGRSVLRRSAVGRRIREAEGFETNMNLSSRDEPSSSEMASETQDRNANNHGTQLSSSLSSVVAAENGNPVTNGLAEDDGCSRLCLSGMGTSSFQRHRESHTTQVIHQLRLSENESVALQELLDWRRKLCESREGWQEAMQHPEPRAPPPPPCKKPTLLKKPEGGSCTRLSSQLWDSSI
What is the function of this protein?
Myosins are actin-based motor molecules with ATPase activity.  Unconventional myosins serve in intracellular movements.  Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).  May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development.  Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).
What are the official names of this protein?
Unconventional myosin-XVI, Myosin heavy chain myr 8, Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3, Unconventional myosin-16.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NYAP family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells.
Protein: KAB12_OLDAF
Sequence: GSLCGDTCFVLGCNDSSCSCNYPICVKD
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Kalata-B12.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebius subfamily.
Protein: LSPA_COXBR
Sequence: MVTKKSKKAWPWLWFSVLVILLDQLSKYLANHFLSLGHPVKILPFLNFTLNYNTGAAFSFLGTENGWQIIFFAAISFVVSIFLILWLSRTSRSEIMMSLGLSLIIGGALGNFIDRLRWSYVTDFIDFHIKDWHFATFNVADSAICVGVFLLIVHMLLTPSSKP
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLMN_VIBA3
Sequence: MTTAKVNLLDFDRKGLRKFFTEELNEKAFRAEQVMKWIYHFGVDDFEQMNNINKKLREKLLHRCEIVAPIVSEAQHSADGTIKWAMSVGDQDVETVYIPDGDRATLCVSSQVGCALECKFCSTAQQGFNRNLKVSEIVGQIWRAAREIGLEKETGRRPITNVVMMGMGEPLLNMKNLIPSLELMLDDLGFSLSKRRVTVSTSGVVSGLDQMTDNIDVALAISLHAPNDALRSQIMPINDRWDIQDFLASVRRYIASSNANRGKVTVEYVLLDHVNDDMDHARELAELMKDTPCKINLIPFNPYPGSPYKKPSNSRIDRFQKTLMEYNYTVTVRKTRGDDIDAACGQLVGDVIDRTKRTKMLKAASEANLIAGDVIQVKAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_FRATW
Sequence: MTLQQIKEIYSRPLTELILQALEIHNKNFGNDIELCSLKSIKTGTCPEDCKYCPQSGHYNTSIEKHKLLDKDSILAEAKNAKDAGSKRFCMGAAWKHIPKKDFDQVAEIITEVKNLGLETCVTLGSINADEATKLKQAGLDYYNHNLDTSREFYPEIITTRKFEERIETIRNVANADINVCCGGILGMGESLDDRFNLLLELLQLPAAPKSIPINTLIPVKGTPLGDKYTNAQIDSFELVRFIATTRILFPQARLRLSAGRENMSLETQTLCFLAGINSIFYGNKLLTENNATVNSDNFLLAKLGLKSNAELC
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: DPP3_NEMVE
Sequence: MAESDFDKTQYIIPNEANINFLECRTAFGGLTEKEKCYAHYLYKASWEGALICLLQTSPEAPGIFLLFQKLFSSESVGSLKEKALKSSVAPTEEEFTSFLTYVAAFYGNIGNYKSFGDTKFIPNLPKEKFQTIVFSSQAYATNAKSVVTLWSDCCEAMYSLKPKLRQLGFGEQGISTYYSSNCNKSDAEFIQGFLKEKNIEGWNTRLFKEINDKGHVTYNLRLASTALSAEDCSAEKKDDVASLVKSYEYQGTTVKITRGDYAGLLKKVVDNLIMAKGFASNENEVAMLDHYVHSFTTGSVEAHKDGSRHWIRDKGPVVETYIGFIESYRDPFGVRAEYEGFVSIVNKSMSAKFADLVSSAETLLPQLPWPSSYEKDTFLRPDFTSLDVLGFGSSGIPAGINIPNYDEIRQDEGFKNVSLGNVLSAHSADQKITFLTEEDAELYSKLKAPSFEVQVGLHELLGHGSGKLFIKKPDGSYNFDHKSVVNTETGEKIQSWYTEGETWSTKFAELSSSYEECRAECVGIYLCLNKDVLRIFGHEGAAGDDIVYVNWLNMVRAGLLGLEFYTPENNKWRQAHMQARYVILRVLLEAGEQLVQLTRIAGSDGKPDILVTLDRNKISCVGQPAIGAFLRKLQVFKSTADYASGKDLYDKYSAVDAHFLEMRNIVLARKTPRRMFVQSHTTIQDGVVSLKEFEASASGMIASFIARFPGDDPVLEKLWRDDLPYHQY
What are the official names of this protein?
Dipeptidyl peptidase 3, Dipeptidyl aminopeptidase III, Dipeptidyl arylamidase III, Dipeptidyl peptidase III, DPP III.
What is the protein family that this protein belongs to?
Belongs to the peptidase M49 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SKG1_YEAS2
Sequence: MTASTSVAVGCAVGIPVGVGIIIAVCFWFNLQKRYKREEQDDRELERAIYDESGFVSFDNFGPLRDSKDEAALASSELKNPDHTSGSSEGSAHPEEKDGKSRDQEKPLGKKNSKYYVPAYRRKINLLQVRNNNYGNNARQKSVVDLPSINNSSNVSLSSSQRHITKRQISVYDQMVPVISDEGPKFFADPSSDTNTSNDQNKASMIELKHNTRQSSNENLIRKLQNQDFGSYYPRRASSSFLNGNISNASFHTRNSSITSVNKRDALEDVFATPKSAAQSQLPNTFDKDNEGIDADHSVKDSRSAITDKDKDIYKLQNNYDVGNIGEIAEEDQYENEFTNYSQSKREFIESLRPK
What is the function of this protein?
Plays a role in cell wall integrity.  Affects the cell wall polymer composition in the growing region of the cell (By similarity).
What are the official names of this protein?
Suppressor of lethality of KEX2 GAS1 double null mutant protein 1.
What is the protein family that this protein belongs to?
Belongs to the SKG1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein; Cytoplasmic side. Bud membrane; Single-pass type III membrane protein; Cytoplasmic side. Note=Localizes on the inner surface of the plasma membrane at the bud and in the daughter cell. Localizes at an incipient bud site in the cells with emerging buds, a bud tip in small- or medium-budded cells, and a cell periphery in large-budded cells.
Protein: SSRP_SALPC
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANIGDSYVILKDGEAWLFGANFTPMAVASTHVVCDPTRTRKLLLNQRELDSLYGRINREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRSDLKEREWQLDKARIMKNAGR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MDTI_SHIB3
Sequence: MAQFEWVHAAWLALAIVLEIVANVFLKFSDGFRRKIFGLLSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRKGWIGLVLLLAGMIMVKLA
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtI.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TGT_LATSS
Sequence: MEPAIKYRLIKKEKHTGARLGEIVTPHGTFKTPMFMPVGTQASVKTMAPEDLKEMGAGIILSNTYHLWLRPGEDIVEKAGGLHKFMNWDRGVLTDSGGFQVFSLAKLRDISEEGVAFKSHLNGEKLFLSPEKAIHVENALGADIMMSFDECPPFFESYDYVKKSVERTSRWAERGLIAHQNPATQGLFGIVQGAGFEDLRRQSARDLVGMDFPGYSIGGLSVGESKGEMNRVLDFTTPMLPEDKPRYLMGVGSPDALIDGVIRGVDMFDCVLPTRIARNGTTMTSQGRLVVKNAKYSEDFRPLDPKCDCYVCKNYTRAYIRHLIKADETFGIHLTSYHNLYFLINLMHQVQDAIEQDNLLEFREAFFEEYGYNENNGRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: Y584_PSEA8
Sequence: MSYVIDRRLNGKNKSTVNRQRFLRRYREHIKKAVEEAVSRRSITDMEHGEQISIPGRDIDEPVLHHGRGGRQTVVHPGNKEFTAGEHIARPSGGGGGRGGGKASNSGEGMDDFVFQITQEEFLDFMFEDLELPNLVKRHITGTDTFKTVRAGISNDGNPSRINIVRTLRSAHARRIALSGGSRAKLRAALKELERIKREEPDNLGDIQELELEIAKLRARIDRVPFLDTFDLKYNLLVKQPNPTSKAVMFCLMDVSGSMTQATKDIAKRFFILLYLFLKRNYEKIEVVFIRHHTSAREVDEEEFFYSRETGGTIVSSALKMMQEIMAERYPTHEWNIYAAQASDGDNWNDDSPVCRDILLKQIMPFVQYYTYVEITPREHQALWFEYERVREAFEDSFAQQQIVSASDIYPVFRELFQRRLVA
What are the official names of this protein?
UPF0229 protein PLES_05841.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: RBM3_HUMAN
Sequence: MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASVAMRAMNGESLDGRQIRVDHAGKSARGTRGGGFGAHGRGRSYSRGGGDQGYGSGRYYDSRPGGYGYGYGRSRDYNGRNQGGYDRYSGGNYRDNYDN
What is the function of this protein?
Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures.  Reduces the relative abundance of microRNAs, when overexpressed.  Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).
What are the official names of this protein?
RNA-binding protein 3, RNA-binding motif protein 3, RNPL.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, dendrite. Note=Localizes in mRNA granules in dentrites.
Protein: CUT1C_ARATH
Sequence: MASISATLPSPLLLTQRKSNLTSIQKLPFSLTRGTNDLSPLSLTRNPSSISLMVKASGESSDSSTDLDVVSTIQNVWDKSEDRLGLIGLGFAGIVALWASLNLITAIDKLPVISSGFELVGILFSTWFTYRYLLFKPDRQELSKIVKKSVADILGQ
What is the function of this protein?
Determines thylakoid architecture by inducing membrane curvature.
What are the official names of this protein?
Protein CURVATURE THYLAKOID 1C, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the CURT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MAMA_MAGMG
Sequence: MSSKPSDILDEVTLYAHYGLSVAKKLGMNMVDAFRAAFSVNDDIRQVYYRDKGISHAKAGRYSQAVMLLEQVYDADAFDVDVALHLGIAYVKTGAVDRGTELLERSLADAPDNVKVATVLGLTYVQVQKYDLAVPLLIKVAEANPINFNVRFRLGVALDNLGRFDEAIDSFKIALGLRPNEGKVHRAIAFSYEQMGRHEEALPHFKKANELDEGASV
What is the function of this protein?
Probably forms a large homooligomer on which other magnetosome subunits assemble.  Required for formation of functional magnetosomes from pre-existing vesicles.
What are the official names of this protein?
Magnetosome protein MamA.
What is the protein family that this protein belongs to?
Belongs to the magnetosome MamA family.
What are the subcellular locations of this protein?
Magnetosome membrane; Peripheral membrane protein. Note=Reversibly binds to magnetosomes (PubMed:16707673). Forms oligomers that cover the surface of the magnetosome (By similarity).
Protein: ISDC_STAAT
Sequence: MKNILKVFNTTILALIIIIATFSNSANAADSGTLNYEVYKYNTNDTSIANDYFNKPAKYIKKNGKLYVQITVNHSHWITGMSIEGHKENIISKNTAKDERTSEFEVSKLNGKIDGKIDVYIDEKVNGKPFKYDHHYNITYKFNGPTDVAGANAPGKDDKNSASGSDKGSDGTTTGQSESNSSNKDKVENPQTNAGTPAYIYAIPVASLALLIAITLFVRKKSKGNVE
What is the function of this protein?
Involved in heme (porphyrin) scavenging.  Binds hemoglobin and almost exclusively free-base protoporphyrin IX.  Probably has a role as the central conduit of the isd heme uptake system, i. e.  mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF.  Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor.  The reaction is reversible (By similarity).
What are the official names of this protein?
Iron-regulated surface determinant protein C, Staphylococcal iron-regulated protein D.
What is the protein family that this protein belongs to?
Belongs to the IsdC family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan- anchor. Note=Anchored to the cell wall by sortase B (By similarity).
Protein: RIBA_HELPY
Sequence: MKRLEVSNQAKLPTQFGEFYIQCFREKGSNGSKDHLVVFTPNFSQNPLVRLHSECLTGDALGSQKCDCGGALQMALERISKEGGLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKDDERDYSVAGEILEYYRIKKMRLLTNNPKKIAALEKYAEVTRESLIVCANEHNQGYLEVKKLKMGHLL
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: MAD1_DEBHA
Sequence: MSDTASSPFIDRPRSMLDEDSEFNSRQLISNLQFQISSLKTEKSLLQQNKESMAEKYEALLITKNEEVVSLQNDFDYVFKQRDELQSKYDNSQQINGKTVESLQVQLKDITERYDELKEEHEYLNSDFKKFCRDNNQVKSDLEFHINSKDQMNEKITSLQDENKSLCKTNDELIEKLNSISEQLVSNTQDKFSRNLQEQNSKLQRTNNQLQLKVDSLLQHRTSVELLRQKNITLTNKLSSLANLEEKCCKLEIENLELSNKFDTFFKTIEDSVNDDTSRTNESVVIEFMNKYKRLQNLNLVLQDKYNQSVTGVKNMQTELSNMQQKYSEAISKVESLNETVSTKTEFIDKLERQKLLNVKEIEYLRDSLKKLEELNLKRSKEETNDKSTEQYMTNLEKLVDEYRTEINTLQKQMSSQEIQSNVQSGSKRPRIIDNGIQNDFKSQVSVLEKENLKLLSTIKNLEYNNKTLGEKLQNLESLDNKKKELHILQLKSNPASQDQLIKQQTLDLLSKENQEMIETFVKNKSAHDMIPKSLFERQENDKLQLQTKIDQLNKRISRLRDIYSQKSRDILSVISKFFGYTIEFLPSPINSNDLSSRIKLVSKYMNNKDESNSAYLILDVNSKSLKANGSLEFKTLCEDLVTNWIREKDQIPCFLSALNLSIYDKYVS
What is the function of this protein?
Central component of the spindle assembly checkpoint.
What are the official names of this protein?
Spindle assembly checkpoint component MAD1, Mitotic arrest deficient protein 1.
What is the protein family that this protein belongs to?
Belongs to the MAD1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS19_STAES
Sequence: MARSIKKGPFVDDHLMKKVEAQDGSEKKQVIKTWSRRSTIFPNFIGHTFAVYDGRKHVPVYVTEDMVGHKLGEFAPTRTFKGHAADDKKTRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.