PharMolix/UniProtQA huggingface dataset:
Protein: GLND_ACIAD
Sequence: MIITSPLLDYVTSHQDIKAINQWRADVEQQLQEFYENGYSIRDIVLARSNLIDEALTFLWKHAGLDQSDLGLFAVGGYGRREMLPYSDVDIMILSENDISPEHEKQISGFISSLWDVGNFKPGTSVRSIQNCVEQATNDLTVATTLIESRLITGNPDLAKWPRRIVSQTWTDKTFFDAKMEEQAKRHAQHNNTESNLEPDIKNAPGGIRDMNQIGWIAKRHFRVNRIYDLVHLGFITEYELKVLEEAESFLWEIRHHLHLLSKRDENRLLFDHQREIAAKFGYTRAEGQPVNFAVEQFMKRYYRTAQQVSTLNEMLLAYFNESVITPRLPNYERKIEEINENFKLVDGKLAVQHHKVFSENPSAILELFYLLANHPEIEGIRARTLRLLIMAAKRIDQEFRDNPAHQALFMAIIRSPYRLYDTLVDMKRYGILGNYIPAFGQIMGLMQYDLFHIYTVDAHTLLLIRNLNRFKEPEFAQHFPVVSSVFQRLARRDIVYLAAIFHDIAKGRGGDHSELGAEDAIEFCRAHGFTERECKLVAWLIHNHLLMSLTAQKKDISDPDVIKEFAEKLGDMEHLDYLYTLTVADINATNPKLWNTWRASLMRQLYTYSRDVIRSGLGRPVDYQMLIEDTKFSASETLVNEFSLDAVEKVWQELGDEYFLKESADEIAWHTRAILQHGDNPAPIVLLRAHRQSAQDAVQIFIYTQDKPNLFATTVAVLDRMNLDVQDARIITATKAFSLDTYVVLDRFGTLLTDPEREHTVKEALIKALSQSDKYPGLMQRRIPRQLRHFDIENTVDITLNPVLQQNMVEISTLDQPGLLARVGGLFMMQGLDIHSAKIATLGERAEDIFFVTKKDGQPMTTDEAHIFSAQLKLALDEASNQIVSQH
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: YQGF_EDWI9
Sequence: MNPRTILAFDFGTRSIGCAIGQELTGSARPLQSFKANDGVPDWQQIEKVLREWQPDLVVVGLPLNMDGSEQPLTQQARKFANRLHGRFGVQIALQDERLSTVEARAHLFAGGGYRALEKGRVDAASAALILESWFENQYR
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_RHOPS
Sequence: MSRIALYPGSFDPVTNGHLDVVRHAVALCDRLVVAIGIHPGKKPLFTTEERLMMVKSVFEPVANAAGCTFDCTTYDNLTVTSAQQVGATLMIRGLRDGTDLDYEMQIAGMNETMAPGIHTVFVPASVGVRPITATLVRQIAAMGGDVSAFVPPDVAASLKSKFAG
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_PSYWF
Sequence: MLSKIVGSVIGTKNDRELKRMRQIVAKVNAQEAAISALTDAQLRDKTAEFKSRFDEGASLDSLLPEAFAVCREASKRVLGMRHYDVQIIGGITLHEGKIAEMRTGEGKTLMATLAIYLNAISGKGVHVVTVNDYLAARDAELNRPLFDFLGLTVGVIYSQQPPYEKVAAYQSDITYGTNNEYGFDYLRDNMVFSLAEKKQRPLNYCIIDEIDSILIDEARTPLIISGQADDSSATYALINNIIPRLTRSTDEEANKENEDGDFWIDEKNRQIEISEKGYEKIESFLIEVGELGENESLYSPIRLPLLAHVQAAIRAHHIFIKNVHYIVDNGEVIIVDENTGRTMPGRRWSDGLHQAVEAKEGVEIQAENQTLATTTFQNYFRLYDKLSGMTGTADTEAAEFKSTYDIDVVVIPTHKPIARIDLEDQIFLTKLGKYKGIIREIKEIQAKGAPVLVGTATIEASEELSYLLDQEGIKHNVLNAKQHEREAEIIAQAGSPKAVTIATNMAGRGTDIILGGNWQAHISDPDNVSPEEMQRLKAAWQKKHDEVLAAGGLHIIGSERHESRRIDNQLRGRAGRQGDPGQSRFFLSLEDDLMRIFAGDRVVNMMRAMGLKEDEAIEHKMVSRSIENAQGKVESRDFDARKNLLKYDDIANEQRKVIYSQRDDLLAEADLKQAIEAMHRDVYDALISQFVPPGSIDDQWNIDGLEDELESEFKYYMPINDWLDSDRRLDEEGLREKIVQTAIARYRERRELMTPENAAQLERHFMLQSLDRHWKEHLTQMDQLRKGIHLRGYAQKDPQQEYKRESFELFQMMLGAIKSDTVQDLSRVHIPTREELEAMEAERLAQAERQQMMFEHDEVDSLTGERHSDPDVEARNLAAEQQATATKAPAAANGNNPYANMNISRNAPCPCGSGLRYKQCHGKI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: MET2A_HUMAN
Sequence: MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557).  N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557).
What are the official names of this protein?
tRNA N(3)-methylcytidine methyltransferase METTL2A, Methyltransferase-like protein 2A.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_LYSSC
Sequence: MRCPSCQFNGTRVVDSRPVDDNKEIRRRRECESCGFRFTTFEKIEETPLVVVKKEGSREEFSREKVLRGLIRACEKRPVALDILEQLVLSIEKDLRRIGNSEVRSEDVGELVMDRLAKIDEVAYVRFASVYRQFKDINVFIEEIKDIIQRQTEQKS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PP2B3_ARATH
Sequence: MAQGEIVPRPSPFDGLPENCISNIISFTTPRDACFAASVSKAFESAVQSDSVWEKFLPLDYSSLVPESRVFLSKKELCFSLCRVPLLIEGGKKSFWLDKTSGEKCIMLSPKGMVISWVNSPQF
What are the official names of this protein?
F-box protein PP2-B3, Protein PHLOEM PROTEIN 2-LIKE B3, AtPP2-B3.
Protein: ATPE_SALPK
Sequence: MAMTYHLDVVSAEQQMFSGLVEKIQVTGSEGELGIYPGHAPLLTAIKPGMIRIVKQHGHEEFIYLSGGILEVQPGSVTVLADTAIRGQDLDEARALEAKRKAEEHIKSSHGDVDYAQASAELAKAIAKLRVIELTKKAM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ACSA_METFK
Sequence: MSSIESVLTETRVFAPHETFRQAATVSGLPGYQALCDAAEQDYTGFWANLARQEISWQTPFTEVLDESNAPFYRWFADGKLNASYNCIDRHLEKRANKIALIFEADNGDVANITYRELHQRVCRFANALKKQGVGLGDRVIIYLPMSIEAIVAMQACARIGAIHSVVFGGFSAKSLHERIVDVGAKLVITADAGIRGGKQVALKASVDEALELGGCESVEKVIVYQRTGVDIAWNPHRDAWWHEVEAAENDNCEPVWVDAEHPLFILYTSGSTGTPKGVQHSTGGYLLGAIMSMKWVFDHKATDIFWCTADVGWITGHSYVAYGPLALGSTQVVFEGVPTYPDAGRFWQMIERHKVSIFYTAPTAIRSLIKLGGDLPHKYDLSSLRLLGTVGEPINPEAWMWYYKVVGKERCPIADTWWQTETGAHMIAPLPGAIDLKPGSCTRPLPGIIMDIVEEDGTHIEGTGGGLLVVKKPWPSMIRNIWGNPERFRKAYFPEELNGLYLAGDSAHRDEDGYFWIMGRIDDVLNVSGHRLGTMEIESALVANPLVAEAAIVGKPHDIKGESIVAYVVLKGERPEGEAAKTIAGQLREWVGKEIGPIAKPDEIRFGENLPKTRSGKIMRRLLRSLAKGEEITSDISTLDNPAILDQLRQSAG
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PMT_CORGL
Sequence: MSQALPVRDQGRDQGIFAGTLPPAPPKFKWTRLDTYTWAIIAVFALVTRFTGLSSATASGTPVFDEKHYVPQAWDMVRSWINPITGGIESNPGYGLVVHPPLAKQLEALGEWVFGYTPLGWRIMVAIFGTLTIFAIMAIARRLSGSTMVTFIAGILALADGVLLVSSRFGMLDIFLVFFITAAAWALIRDHQQMHQRLNDLLLTNGQITKDFGPRFGFRWWRFTTGVFLGLALSVKWSGLYYIAFFGLTSVFLDLWLRKRYGVRRYVTGTLKNDVIPALGSLVIIPALLYIWSWRAWFASETSVYRHAKTDGTITEDSILQLFPESIAGWIHYHISVLEFHGSLTTSSGHSHPWDSKPWAWLVSGRPILYFSSTDISCDVGGTCRRMIYLFGTPAIWWLTVPVILWALWSFFARRSRGYVVPLVAFAAGFLPWLAAYDRQMYFFYATALVPFTIIMLALACGELWGRGKMTPTGLTRGSMAVVTYISLVVMMFLAFSPLFYGFVIPDYVYESLMWFPSWR
What is the function of this protein?
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.
What are the official names of this protein?
Probable dolichyl-phosphate-mannose--protein mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 39 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACYP_SACEN
Sequence: MVTDAQQARLTAWVHGRVQGVGFRWWTRARALELGLAGSATNLPGNRVEVVAEGPRESCERLLEALRSPDTPGDVDHVAEQWSEPKGGLTGFVER
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: SYT_XYLFA
Sequence: MITITLPDGSRREFEGPVSVMQVAHAIGPGLAKATIAGQIDGGHLVDASDLIEHDAMLRIITPEDQEALDIIRHSCAHLVGHAVKQLYPEAKMVIGPVIADGFYYDIYSKRPFTPEDLAAIEQRMVELIAQDYHVVKHITARHDVVRLFKERGEDYKLRLIEEMGPEVTAMGIYHHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDTKNEQLQRIYGTAWADKKQLEAHMQRLQDAEKRDHRKIGKVQDLFHLQEEGPGLVFWHPKGWVIWQTIENYIRRVYRNSGYGELRCPQILDVSLWQKSGHWDNYKENMFFTDSEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGLLRVRGFTQDDGHIFCTEAQIESEVTAFHRQALQVYADFGFEDIQIKIALRPDKRLGDSLSWDKAEAALRAALSACEVEWQELPGEGAFYGPKIEYHLKDAIGRTWQLGTIQVDFMMPGRLGAEYVDERSQRCHPVMLHRAIVGSMERFIGILIEHYAGIWPTWLAPVQVVVANITDAQYEYAERVHKALLNQGFRVNTDLRNEKIGYKIREHTLQRVPYLLVVGDREKENGTVAVRTCSREDLGAMSISAFVERLQAEQVV
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_NAUPA
Sequence: MIKVAILGKPNVGKSSLFNRILRERDAIVSEKAGTTRDIKKREVSLDDDLEEIVLLDTGGLEERDELFNKVKEKALEVAKEADLVLYMVDGKTIPDEEEIKYFRNLQKLGKHIILVVNKIDNDKMMEKVYDFYELGADEIFPISVSHNRGVGKLIERIKKFVPKKPKTFEVSEFEQEIPLEDLLVAEENEENLEELKEIKVAIVGRVNVGKSSLLNALVGEERAIVSDVDGTTIDPIDENIYHDGWNITFVDTAGIRRRSKIKDIEKYALLRTEKVLEEADIAILVIDAKEGIVELDEKIGGLIDKHKNGVIIVANKWDENAEEFHKFRKEVYYRFKYLYFAPFLAVSAKTGRNIDKLKDEIIRVYKNYSKRIPTATLNKWIEEATIRHHLPTDIGGKEVKIFYATQYKTKPPTIALIMNRNKLHFSYRRYLVNFLRKKEDFEGTPIIFVARKKGEKHEEA
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: SSN8_ASPFU
Sequence: MAANYWASTQRRHWLFTREKLAEIREIFREGDKVAHSQFPLPDQRLLNIYFSQQLIKLGKRMSTRQQALATAQVYIKRFYTKNEIRHTNPYLVLTTAFYLACKMEECPQHIRFVVGEARSLWPEFITPDVSKLGECEFSLISEMNSQLIVHHPYRTLSELQPELSLTSDEVALAWSVINDHYLTDLPLLYAPHVIAVMAIIVAVVFKPNSGNFHGSAAPVLAGAMRDGGMNVLAALGDRTGSGPPLKIQKLINWLAESEVDIKGVIECTQELVSLYEVWEQYSEKTCKELLGRMVKAKNLDK
What is the function of this protein?
Component of the srb8-11 complex.  The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
RNA polymerase II holoenzyme cyclin-like subunit.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RRB1_YEAST
Sequence: MSKRSIEVNEEQDRVVSAKTESHSVPAIPASEEQDAPKNDLEEQLSDEFDSDGEIIEIDGDDEINDEDDLRKKQEEAETLVQKDQSEGNKEKIQELYLPHMSRPLGPDEVLEADPTVYEMLHNVNMPWPCLTLDVIPDTLGSERRNYPQSILLTTATQSSRKKENELMVLALSNLAKTLLKDDNEGEDDEEDDEDDVDPVIENENIPLRDTTNRLKVSPFAISNQEVLTATMSENGDVYIYNLAPQSKAFSTPGYQIPKSAKRPIHTVKNHGNVEGYGLDWSPLIKTGALLSGDCSGQIYFTQRHTSRWVTDKQPFTVSNNKSIEDIQWSRTESTVFATAGCDGYIRIWDTRSKKHKPAISVKASNTDVNVISWSDKIGYLLASGDDNGTWGVWDLRQFTPSNADAVQPVAQYDFHKGAITSIAFNPLDESIVAVGSEDNTVTLWDLSVEADDEEIKQQAAETKELQEIPPQLLFVHWQKEVKDVKWHKQIPGCLVSTGTDGLNVWKTISV
What is the function of this protein?
Involved in regulation of L3 expression and stability and plays a role in early 60S ribosomal subunit assembly.  May be required for proper assembly of pre-ribosomal particles during early ribosome biogenesis, presumably by targeting L3 onto the 35S precursor rRNA.
What are the official names of this protein?
Ribosome assembly protein RRB1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOY_LEVBA
Sequence: MIYKVYYQNDQKRNPKREDTHSLYLEAPTEVEARALVEAHTEHNIEFIEAIEGETLAYEQQNPNYKLTEFSE
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.
Protein: LECE_HELCR
Sequence: GCCPTFWTSFGSNCYRFFAVSLTWAEGEQFCQSFSVPSRGDIDSIGHLVSIHSETEQNFVYHYFETSTKDDTTPEMWLGFNDRTTEGNFQWTDGSPNDFTAWVGSNPDNYGSGEDCTQMVMGAGLNWIDLPCSSTRHYLICKLPLWE
What is the function of this protein?
Role in the defense system of the organism against microorganisms.  This lectin is specific for Gal-GalNAc.
What are the official names of this protein?
Echinoidin.
What are the subcellular locations of this protein?
Secreted.
Protein: SDHE_VIBVY
Sequence: MYTTEEKARIRWACRRGMLELDVVVMPFFEECFDKLSEQEQRDFVSLLECDDPDLFTWVMGHGRSENLGHASMVDKIVAHNLSKVR
What is the function of this protein?
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins.  Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
What are the official names of this protein?
FAD assembly factor SdhE.
What is the protein family that this protein belongs to?
Belongs to the SdhE FAD assembly factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_LEGPH
Sequence: MAKELRFGDDARLQMLAGVNALADAVQVTMGPRGRNVVLEKSYGAPTVTKDGVSVAKEIEFEHRFMNMGAQMVKEVASKTSDTAGDGTTTATVLARSILVEGHKAVAAGMNPMDLKRGIDKAVLAVTKKLQAMSKPCKDSKAIAQVGTISANSDEAIGAIIAEAMEKVGKEGVITVEDGNGLENELSVVEGMQFDRGYISPYFINNQQNMSCELEHPFILLVDKKVSSIREMLSVLEGVAKSGRPLLIIAEDVEGEALATLVVNNMRGIVKVCAVKAPGFGDRRKAMLQDIAILTKGQVISEEIGKSLEGATLEDLGSAKRIVVTKENTTIIDGEGKATEINARITQIRAQMEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVAGGGVALIRAQKALDSLKGDNDDQNMGINILRRAIESPMRQIVTNAGYEASVVVNKVAEHKDNYGFNAATGEYGDMVEMGILDPTKVTRMALQNAASVASLMLTTECMVADLPKKEEGVGAGDMGGMGGMGGMGGMM
What is the function of this protein?
May play a protective role against the defense mechanisms generated by the infected macrophages.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QMCA_ECOL6
Sequence: MLIFIPILIFVALVIVGAGVKIVPQGYQWTVERFGRYTKTLQPGLSLVVPFMDRIGRKINMMEQVLDIPSQEVISKDNANVTIDAVCFIQVIDAPRAAYEVSNLELAIINLTMTNIRTVLGSMELDEMLSQRDSINSRLLRIVDEATNPWGIKVTRIEIRDVRPPAELISSMNAQMKAERTKRAYILEAEGIRQAEILKAEGEKQSQILKAEGERQSAFLQAEARERSAEAEARATKMVSEAIASGDIQAVNYFVAQKYTEALQQIGSSSNSKVVMMPLEASSLMGSIAGIAELVKDSANKRTQP
What are the official names of this protein?
Protein QmcA.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL322_STRCO
Sequence: MAVPKRRMSRSNTRHRRAQWKASTPNLVPVTVDGVTLRVPRHLVPAYRRGLLRPEI
What are the official names of this protein?
50S ribosomal protein L32-2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: ERL2A_XENLA
Sequence: MSHAGAIVGLGVALIAAALFSAIHKIEEGHVGVYYRGGALLSTTSGPGFHLMFPFITSFKSVQSTLQTDEIKNVPCGTSGGVMIYFDRIEVVNYLISSAVYDIVKNFTADYDKALIFNKIHHELNQFCSVHNLQEVYIELFDQIDENLKLALQEDLNLMAPGIIIQAVRVTKPKIPEAIGRNFELMEGEKTKLLIAAQKQKVVEKEAETERKKAIIEAEKVAQVAQIKYKQKVMEKETEKKISEIEDFAFVAREKARADAEYYTAHKVAEANRLKLTPEYLQLVKYQAIAANSKIYFGQDIPNMFMDSSAGPRVQSATVFQDDSLGLDEAASAEE
What is the function of this protein?
Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).  Promotes sterol-accelerated ERAD of HMGCR.  Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (By similarity).
What are the official names of this protein?
Erlin-2-A, Endoplasmic reticulum lipid raft-associated protein 2-A, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2-A, SPFH domain-containing protein 2-A.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Protein: VP7_ROTP5
Sequence: MYGIEYTTVLTFLISLVFVNYILKSVTRTMDFIIYRFLLVIVVLAPLIKAQNYGINLPITGSMDTPYMNSTTSETFLTSTLCLYYPNEAATEIADTKWTETLSQLFLTKGWPTGSVYFKGYADIASFSVEPQLYCDYNIVLMKYDGNLQLDMSELAGLILNEWLCNPMDIMLYYYQQTDEANKWISMGTSCTIKVCPLNTQTLGIGCSTTDINSFETVANAEKLAITDVVDGVNHKLDVTTSTCTIRNCKKLGPRENVAVIQVGGPNILDITADPTTAPQTERMMRINWKRWWQVFYTIVDYVNQIVQVMSKRSRSLDSAAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: GUAA_SHIBS
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMHMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: CEC4_BOMMO
Sequence: RWKIFKKIEKVGQNIRDGIVKAGPAVAVVGQAATI
What is the function of this protein?
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Cecropin, Antibacterial peptide CM-IV.
What is the protein family that this protein belongs to?
Belongs to the cecropin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_YERE8
Sequence: MLIKLLTKVFGSRNDRTLRRMRKVVDLINRMEPEVEKLTNEELRAKTDEFRERLANGAVLETLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALSGRGVHVVTVNDYLAQRDAENNRPLFEFLGLSVGINLPNMPAPAKRAAYAADITYGTNNEFGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYIRVNKLIPKLIRQEKEDSDTFQGEGHFSVDEKSRQVHLTERGLIKIEEMLVEAGIMEEGESLYSPANIMLMHHVTAALRAHVLFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTIVVPTNRPMIRKDLADLVYMTEQEKIGAIIEDIRERTANGQPVLVGTISIEKSEVVSAELTKAGIEHKVLNAKFHAMEAEIVSQAGQPGAVTIATNMAGRGTDIVLGGSWQSEIALLENPTEDQIAAIKAAWQIRHDAVLASGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVASDQRRAIYSQRNELLDVADVSETINSIREDVFKTVIDSYIPTQSLEEMWDVEGLEQRLKNDFDLDMPIAQWLEDEPQLHEETLRERILQLAIADYQRKEEVVGFDMMRNFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFAMFAAMLESLKYEVISVLSKVQVRMPEEVEALEVQRREEAERLAKQQQLSHESDNSALMSQEEANVAASLERKVGRNDPCPCGSGKKYKQCHGRLQ
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CYTB_HELAN
Sequence: IPGGRTKVKNVKTDTEIQQLGSYSVDEYNRLQRTKKTGAGDLKFSQVIAAETQVVAGTKYYLKIEAITKGGKMKVFDAEVVVQSWKHSKKLLGFKPAPVDK
What is the function of this protein?
Strong inhibitor of papain, ficin and cathepsin H, B and L.
What are the official names of this protein?
Cysteine proteinase inhibitor B, Cystatin-B, SCB.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.