PharMolix/UniProtQA huggingface dataset:
Protein: NHAA1_NOCSJ
Sequence: MTGRRPTRPRLFSRGSFLESSRVADILRAETTGGLLLIAAATVAIVWANTPWSASYADLRDLRVGPQAWHLDLTLGAWAADGLLAIFFFVAGLELKREFVAGDLRDPRRAALPVVAAMGGMAVPALVYVLWNLGGDGALQGWAIPTATDIAFAVAILAVISTHLPTGLRTFLLTLAVVDDLLAITIIALFYTDELHLGYLAAAAVPLLVFALLVQRRIHRGWLLIPLAATAWVLVHESGVHATVAGVLLGFAVPVLRSDGQEGPGLAEHLEHLVRPLSAGLAVPVFAFFAAGVTVGGFDGLVDALSDPVALGVVTGLVVGKTVGIAGSTWLLATFTRADLDDQLSWVDVVGLAMLAGIGFTVSLLIGELAFGSGTPRDDHVKVGVLVGSLAATALATGVLRMRNRAYRRLVEIEEQDADADGVPDVYQRDADEG
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPD_STRLI
Sequence: MSGMHGASREALAAARERLDALTDSTSVDAGSLADELAAVTALLHREVSLRRVLTDPAQSARPRPSSPSVSSAPRSAAPVDLVAGTVRSRWSQSRDLVDALEQLANIADLTAAQKRGRLDNVEDELFRFGRIISSNTELRAALTSRSATTAAKSELLAGLLGSRAERTTERLVTRLVTAPRGRSLESGLESLSKLAADRRDRMVAVVTSAVPLSDTQKQRLGAALAKVYGRPMHLNLDVDPEVLGGIRVQVGDEVINGSIADRLEDAGRRLAS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KCMB1_MOUSE
Sequence: MGKKLVMAQKRGETRALCLGVAMVVCAAITYYVLGTTVLPLYQKSVWTQESICHLIETNIKDQEELEGKKVPQYPCLWVNVSAVGRWAMLYHTEDTRDQNQQCSYIPRNLDNYQTALADVKKVRANFYKHHEFYCLSAPQVNETSVVYQRLYGPQVLLFSFFWPTFLLTGGLLLIAMVKLNRSLSILAAQK
What is the function of this protein?
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel.  Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.  Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel.  It also modifies KCNMA1 channel kinetics and alters its pharmacological properties.  It slows down the activation and the deactivation kinetics of the channel.  Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1.  Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2).  Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
What are the official names of this protein?
Calcium-activated potassium channel subunit beta-1, BK channel subunit beta-1, BKbeta, BKbeta1, Calcium-activated potassium channel, subfamily M subunit beta-1, Calcium-activated potassium channel subunit beta, Charybdotoxin receptor subunit beta-1, K(VCA)beta-1, Maxi K channel subunit beta-1, Slo-beta-1, Slo-beta.
What is the protein family that this protein belongs to?
Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: WDR33_CAEEL
Sequence: MNGGMMRGNQMPNVTLTIQPSTSSMQNSQPRIMNNHHHPHNRFQREHVMPDVMGDGPGRRLRKNVANVRRHVDYVSTVLNHCENRLWQYGKQRILQQPDILYQQYAVPADSTPDVPVDCILTKFIRTAMNKVKCPVYSVCWSPEGKRLITGCQTGEFTLWNGTAFNFETILQAHDSAIRALKWASNEQWLLSADQGGYVKYWQPNMNNAHMFSAHKDEAIRGLAFAPTDVKFATASDDGTARVWDFARYTEERVLRGHGAEVRCIDWHPTKGLIATGSRDTQQPVKIWDPKSGSCLATLQEHKSSVMAVEFNKNGNWLLTGGRDHLVKMYDIRMMKEMRTYRAHKKEVISLAWHPIHEGLFVSGGGDGSIVYWMVDGEKEIGLLEHAHDQAIWSMKWHPLGHILATGSNDNNTKFWARNRPGDTVEDIFGLSNTNMIGHLDKEREPRMAPPKPSIETQETYRPDTFIPGMGLDEHLYEQLNRDHNMMTTDSTLLVPDDLTRQNFAPMIGAKRTLIKQPPAKKAQRQFERMWNNSKGIGAGSDDFTTMKGGLGREDAEGAQFGPSKSFLGPPTTGGSLLGPSQPRPQEFRSVPPPQQQQGPPPNWRHQGPPMSGPGQGYGPPGRMGGNQGGWQRPPPQGSYGGQGPPQGSYGGQGTLQGSYASQQGPPPRQIQHIPSDIDYRTAPSSSNGSTGDVDMRTMVPNQPPSGEPEHWRGPPPVSHQQQSQQQHPPPINMQRMDPRRDPRMLSGRSDQLSPSGPPPQQQQSSAQQGGKNQWMPQFEAGQNQNQGNYAGNRGGGVGGRGRGRGQPY
What is the function of this protein?
Essential for both cleavage and polyadenylation of pre-mRNA 3' ends (By similarity).  Involved in neuron development, probably by regulating pre-mRNA 3'-end processing (PubMed:20530551).
What are the official names of this protein?
pre-mRNA 3' end processing protein pfs-2, Polyadenylation factor subunit homolog 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR33 family.
What are the subcellular locations of this protein?
Nucleus speckle. Note=Also localizes to a small subnuclear ring in neurons. In neurons, partially co-localizes with sydn-1 in the nucleus.
Protein: XNI_VIBVY
Sequence: MAIHLVIIDALNLIRRVHSAQPDPTDIANTIQNTCRTLQRIISESHPTHIVAVFDHLGSDRGWRAEILPEYKQGRKPMPEPLLNGLEKIQDAWWQLGIDSLLSEGDEADDLVATLACKVAQHGEKVTIISTDKGYCQLLSPTLQIRDYFQHRWLDQPFIEQEFGVKPQQLSDYWGLTGISSSQVTGIPGIGPKAAKEILSQFDDIEQAFLSPDLPKKYRTKFDQHIELARRCKRVSALKTDIELGFNLQDLRFTANETH
What is the function of this protein?
Has flap endonuclease activity.  During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
What are the official names of this protein?
Flap endonuclease Xni, FEN.
What is the protein family that this protein belongs to?
Belongs to the Xni family.
Protein: CBHC_ASPCL
Sequence: MKNFAPSLALSLLLPTVQAQQTMWGQCGGAGWSGATDCVAGGVCSTQNAYYAQCLPGATTATTLSTTSKGTTTTTTSSTTSTGGGSSSTTTKTSTSAGPTVTGSPSGNPFSGYQQYANPYYSSEVHTLAIPSMTGALAVKASAVADVPSFVWLDVAAKVPTMGTYLENIRAKNKAGANPPVAGIFVVYDLPDRDCAALASNGEYAIADGGIAKYKAYIDAIRAQLLKYPDVHTILVIEPDSLANLITNINVAKCSGAKDAYLECINYALKQLNLPNVAMYIDAGHGGWLGWDANIGPAAEMYAKVYKDADAPAALRGLAVNVANYNAWTIDTCPSYTQGNKNCDEKRYIHALYPLLKAAGWDARFIMDTGRNGVQPTKQQAQGDWCNVIGTGFGIRPSSETGDDLLDAFVWVKPGAESDGTSDTTAARYDAHCGYTDALKPAPEAGQWFQAYFEQLLTNANPAF
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Probable 1,4-beta-D-glucan cellobiohydrolase C, Beta-glucancellobiohydrolase C, Exocellobiohydrolase C, Exoglucanase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 6 (cellulase B) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAZ_LISIN
Sequence: MFMGEYQHNIDIKGRLIVPAKFRELLGDNFVITRGLDKCLFAYPQEEWKKLEEKLQTLPLTKKDARSFTRFFFSGASECELDKQGRINIPSNLLQYADLEKETVIIGVSSRIEIWSKSEWDNVFNEAEESFADLAENMIGFDI
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: KBAZ_ECOSE
Sequence: MKHLTEMVRQHKAGKTNGIYAVCSAHPLVLEAAIRYASANQTPLLIEATSNQVDQFGGYTGMTPADFRGFVCQLADSLNFPQDALILGGDHLGPNRWQNLPAAQAMANADDLIKSYVAAGFKKIHLDCSMSCQDDPIPLTDDIVAERAARLAKVAEETCLEHFGEADLEYVIGTEVPVPGGAHETLSELAVTTPDAARATLEAHRHAFEKQGLNAIWPRIIALVVQPGVEFDHTNVIDYQPAKASALSQMVENYETLIFEAHSTDYQTPQSLRQLVIDHFAILKVGPALTFALREALFSLAAIEEELVPAKACSGLRQVLEDVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFAHLVRNLADSPIPLPLISQYLPLQYVKVRSGELQPTPRELIINHIQDILAQYYTACEGQ
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of KbaY.  When expressed alone, KbaZ does not show any aldolase activity.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. KbaZ subfamily.
Protein: NSP4_ROTE1
Sequence: MDKLTDLNYTLNVITLINSTLHTILEDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVIKEMRRHLEMIDKLTTREIEQVELLKRIYDKLMIRATDEIDMSKEINQKNVRTLEEWENGKNPYESKEVTAAM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: TRUB_GEOKA
Sequence: MDGVLLLNKPKGMTSHDCVAKVRRLLGVKKAGHTGTLDPNVSGVLPICLGKATRIAEFLTGTTKTYEGKVTLGAATTTEDADGDIIAARPVDRPIARAEIEAVFDSLTGEIEQTPPMYSAVKVGGKKLYEYARAGIEVERPTRRVTIYELELLDEREQFFGETVSFRFRVTCSKGTYVRTLAVMIGERLGYPAHMSDLIRTASGPFRLEDCVTFEDVERRAADGTADALLIPIERALFHLPKYEINDKVAEKVKNGALLRLPAFLEKLTGRSCLFRPSGKRWPCT
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: ACKA_METMA
Sequence: MKVLVINAGSSSLKYQLIDMTNESALAIGLCERIGIDNSIITQKRFDGKKLEKQTDLPNHKIALEEVVKALTDSEFGVIKSMDEINAVGHRVVHGGEKFNSSALINEGVEQAIKDCFELAPLHNPPNMMGISSCQEIMPGVPMVAVFDTAFHHTIPPYAYMYALPYELYEKYGIRKYGFHGTSHFYVAKRAAAMLGKPEQDVKVITCHLGNGSSITAVKGGKSIETTMGFTPLEGVAMGTRCGSIDPAVVPFIMEKEGLSTREIDTLMNKKSGVLGVSSLSNDFRDLDEAASKGNQKAELALEIFAYKIKKVIGEYIAVLNGVDAIVFTAGIGENSASIRKRILADLDGIGIKIDEEKNKIRGQEIDISTPDATVRVLVIPTNEELTIARDTKEICETEVKLRSSVPI
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE2_BURVG
Sequence: MIPGEILTDDGEHELNAGRATRSLVVANTGDRPVQVGSHYHFFEVNDALSFDRAAARGFRLNIAAGTAVRFEPGQTRTVELVELAGDRAVYGFQGKVMGPL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEN1C_MOUSE
Sequence: MGSTETRHPPAMFDWFFEAGCPNSLEEDPPILRQFPPDFQEQEAMQMVPRFCFPFDIEREPPSPAVQHFTFALTDLVGNRRFGFCRLRAGARSCLCILSHFPWFEVFYKILNNVGDLLAQNQVAEAEELLQNLQQHPLLGPRFSGRSEMDSSITVRSECGILPPALGNSKLLSCFVAPDAASLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHGSLAERVREKALEDVVVLNADSNTLETPFDDVQALPPDVVSLLRLRLRKVALSPGEGVSRLFLKVQALLFGGYRDALVCIPGQPVTFSEEAFLAQKPGAPLQAFHKKAVHLQLFKQFIESRLEKLNAGEGFSDQFEQEIIACRGASSGTLRSYQLWVDSLKKGSDALLHSMKTKTQPAVRNMYRSGDSLQEYCASKAKSGLKGMQNLLTIKDGDSGLQRGGSLRTPSLTSRSDRLQQRLPISQHFGQNRPLRPSRRLKTEEGPSEPLRERSPTLSPGDTQNPWAEDTLDGSFLGSGEELDLLSEILDSLNVETKSGDLQRASQSLDCCQRGAASESCSSLPDIPVGLPWQLEEDKRSQDPQPWSLPGDLSLLQDTPFSEVVSYSKNSCSQPFQQSPPSQGDPGPSLSKLDPRPSQSPCPKLLRVPTRHSPPESPQLLVSTEPNSDAVQRLQSISSPSCSHSAENPRNQPPQVLLGQACVQPLEELGAPTYVSHVSTQQRPQDKQPRVADLKKCFEN
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35.  Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
What are the official names of this protein?
DENN domain-containing protein 1C, Connecdenn 3.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle.
Protein: 6PGL4_ARATH
Sequence: MASVLEKTKSKKIVFPTKKELSEAMATYTANLSAKFCKERGYFTVVLSGGDLISWLSELLEPKYQESIEWSKWHIFWVDERVVPLDHEDSNYKLAFDGFLSKVPIPIANIYPIDKDCAALGDAKSAALLYEECLKRLVNRNIIRTYKSSGFPQFDLQLLGMGPDGHMASLFPGHYQIKEKANLVTYITDSPKPPPKRITFTLPVINCASYNLMAVCDEAQADAVAKVFNHNFDLPAAWLTADVEAIWFLDQAAASKIPKGL
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
Probable 6-phosphogluconolactonase 4, 6PGL4.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RS2_ALCBS
Sequence: MSSVTMRDMLKAGVHFGHQTRYWNPKMNTYIFGARNKIHIINLEQTLPLFNDAMAFLNKLAASNNKILFVGTKRAAQKAVSEEAQRCGMPYVDHRWLGGMLTNWKTIRQSIKRYRELEAQFQDGTFDKLTKKEALMRKREMDKLERSIGGIKDMGGLPDALFVIDVDHEDIALQEARKLGIPVVAVVDTNSNPDGVDYVIPGNDDAIRAIQLYVKAAADVILEGKQYAQNQTGGESEFVEVADEAAGEKAEG
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RL40_PONPY
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK
What is the function of this protein?
Component of the 60S subunit of the ribosome.  Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
What are the official names of this protein?
Ubiquitin-60S ribosomal protein L40, Ubiquitin A-52 residue ribosomal protein fusion product 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [60S ribosomal protein L40]: Cytoplasm.
Protein: RNPA_HALHL
Sequence: MSADERFPRGARLLRRREFEGVLRAPEWRTANRYFRVSARQNQCGRPRLGLAVPKRVLRLAIQRHRVKRIIRESFRVRQGGLPDHDFVVGVRGAVAEADNATLFSALEELWAHARGRPCDGS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: LIPA_RICPR
Sequence: MTNLNKRPDWIKVKAPNSVEYYQTKDLIKNLRLNTVCEEAACPNIGDCWSRKHATVMILGAVCTRACRFCNVKTGRPDLLDPHEPRRLAEAVQKLNLQHVVITSVDRDDLEDGGASHFAECINEIRRSSPNTTIEILTPDFLRKEGAVEIIANAKPDVFNHNVETVPSLYKTIRPGARYYNSLSLLHNIKKLSPEIFTKSGMMVGLGEEINEVVQVMDDLREANVDFLTIGQYLQPTKSHAEIRKYVTPEEFKYLERIAKTKGFLMVSATPLTRSSYHADKDFQKLKGNYNIRLASM
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILDR2_MOUSE
Sequence: MPAFPTLDLDGKLGKMDRVVLGWTAVFWLTAMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSPRAQALSKRNLEWDPYLDCLDSRRTVRVVASKQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVILGIFLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHDDDSNFRQSYHQMRNKQFPMSGDLESNPDYWSGVMGGNSGTNRGPALEYNKEDRESFRHSQQRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRSRRANGNSHEARAGSRFERSESRAHGAFYQDGSLDEYYGRGRSREPPGDGERGWTYSPAPARRRPPEDAPLPRLVSRTPGTAPKYDHSYLSSVLERQARPESSSRGGSLETPSKLGAQLGPRSASYYAWSPPTTYKAGASEGEDEDDAADEDALPPYSELELSRGELSRGPSYRGRDLSFHSNSEKRRKKEPAKKPGDFPTRMSLVV
What is the function of this protein?
May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion (PubMed:33863978, PubMed:23826244).  With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (PubMed:23239027).  Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694).  In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060).
What are the official names of this protein?
Immunoglobulin-like domain-containing receptor 2, Angulin-3, Lisch-like protein.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. LISCH7 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cell junction, tight junction. Nucleus.
Protein: PSD_NITEU
Sequence: MSTPYYPHPIIAREGWPFIAGAFAVALLVQFMAGWLWALPFWLIALFVLQFFRDPPRVVPALAGAVLAPADGRIVAVDKVQDPYLPREALKVSVFMNVFNVHSNRSPVDGEIRNRWYFPGNFLNASLPKASLENERNALWIRTDGGQDVTCVQIAGLIAKRIVCHVHPGEHLARGQRFGFIRFGSRVDVYLPLGTKVNVAIGDKVYATQTVLAEFH
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RSSA_ENCCU
Sequence: MPQDNTRISDSIKIPDEFVKLLIVSQSHLGGTSTNKSFARYLYGTRPRDRINIIDINATWEKLIIAARAFCGIKHPSSIAVVSTKTFGRKPVVKFCEAVGATPITGRFIPGSFTNSEVKRVYDPRVLIVSDTYADKQAILESQYCNLPTIAFVNTDNSLVGVDIAIPMNNRSPSAIAAGFFILSRLINYMKTGAELVRDMKEVELFLFRDSVELEQLVEEQLLETTDSILNVGKEGILSGIGTGNADEWNSF
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_CHLTB
Sequence: MKVKICGITHPDDAREAAKAGADYIGMIFAKDSRRCVSEEKAKYIVEAIQEGNSEPVGVFPEHSVEEILAITEATGITSIQLSGEDILFKFSQLREHFSIFYVVSVYSNGQPSAALPPMNDAVTVVYDHIGGERGSPFDWKAFSPFQHNNWMLGGGVNLWNIKEGISLLNPRGIDVSSGVERPGILRKDIFLMQALINSAKELSSSTL
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RS3_PSEU2
Sequence: MGQKVHPIGIRLGIVKEHTSVWYADGRTYADYLFADLKVREYLQDKLKSASVSRIDIHRPAQTARITIHTARPGIVIGKKGEDVEKLRQDLTKQMGVPVHINIEEIRKPELDGMLVAQSVAQQLERRVMFRRAMKRAVQNAMRIGAKGIKIQVSGRLGGAEIARTEWYREGRVPLHTLRADIDYANYEAHTTYGVIGVKVWIFKGEVIGGRQEELKPQAPAPRKKAAK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RS6_CHLT2
Sequence: MKKKTGQLYEGAYVFSVTLSEDARRKALEKVTSGITNYGGEVLKIHDQGRKKLAYTIRGAREGYYYFIYFTVAPEAIAELWREYHLNEDLLRFMTLKASAVKEVLEFATLPE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: SYS_MYCGE
Sequence: MLDPNKLRNNYDFFKKKLLERNVNEQLLNQFIQTDKLMRKNLQQLELANQKQSLLAKQVAKQKDNKKLLAESKELKQKIENLNNAYKDSQNISQDLLLNFPNIAHESVPVGKNESANLELLKEGRKPVFDFKPLPHRELCEKLNLVAFDKATKISGTRFVAYTDKAAKLLRAITNLMIDLNKSKYQEWNLPVVINELSLRSTGQLPKFKDDVFKLENTRYYLSPTLEVQLINLHANEIFNEEDLPKYYTATGINFRQEAGSAGKQTKGTIRLHQFQKTELVKFCKPENAINELEAMVRDAEQILKALKLPFRRLLLCTGDMGFSAEKTYDLEVWMAASNEYREVSSCSSCGDFQARRAMIRYKDINNGKNSYVATLNGTALSIDRIFAAILENFQTKDGKILIPQALKKYLDFDTIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_CHICK
Sequence: MAAARSCNGYARREGPPSPKLGTEKPRVSAGSGGSGDGWRGERPRSEEDNELSLPSLAAAYTTILRALGEDPERQGLLKTPWRAATAMQFFTKGYQETIADVLNDAIFDEDHDEMVIVKNIDMFSLCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAIAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTATSTMLGVFREDPKTREEFLTLIRS
What is the function of this protein?
May positively regulate nitric oxide synthesis in endothelial cells.  May be involved in dopamine synthesis.  May modify pain sensitivity and persistence.
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RN141_BOVIN
Sequence: MGQQISDQTQLVLNKLPEKVAKHVMLVRESGSLTYEEFLGRVAELNDVTAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITSQAAGVLAQSSTSEDADENSASVTSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP
What is the function of this protein?
May be involved in spermatogenesis.
What are the official names of this protein?
RING finger protein 141.
What are the subcellular locations of this protein?
Membrane; Lipid- anchor.