PharMolix/UniProtQA huggingface dataset:
Protein: WIPF1_MOUSE
Sequence: MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGASAGGYGGGGGGGGGGGGGGGGSGGNFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPILPPGGRATSAKPFSPPSGPGRFPAPSPGHRSGPPEPPRNRMPPPRPDVGSKPDSLPPPVPNTPRPVPSSLHNRGSPAGLGAPRPPFPGNRGAAFGAGSARQNPSGSSSPFPRPPLPPTPSRALDDKPPPPPPPVGNRPSMHREAVPPPPSQTSKPPVPSTPRPGLGSQAPPPPPPPSRPGPPPLPPASNDEIPRLPQRNLSLTSSAPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPINRNGSTARALPATPQLPSRSGMDSPRSGPRPPLPPDRPGAGAPPPPPPSTSVRNGFQDSSCEDEWESRFYFHPISDLPPPEPYVPTTKTYPSKLARNESRSGSNRRERGAPPLPPIPR
What is the function of this protein?
Plays a role in the reorganization of the actin cytoskeleton.  Contributes with NCK1 and GRB2 in the recruitment and activation of WASL.  May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity).  Plays a role in the formation of cell ruffles.
What are the official names of this protein?
WAS/WASL-interacting protein family member 1, Wiskott-Aldrich syndrome protein-interacting protein, WASP-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the verprolin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).
Protein: COAA_LEVBA
Sequence: MRDPINYNAFTREQWQQFSADATLPLTQESLRQIKAFNDRISLQDVQDIYIPLVHLVHLEFDHYRQLQRDKATFLKQPQQRVPFIIGIAGSVAVGKSTAARLLEVLLNHYFTDQRIQLITTDGFLYSNEELKKRNLMARKGFPESYDMTALIQFLNDVKAGKELIKAPVYSHKVYDIVPDQFDYIMHPDVLIVEGINTLQLPTNEQIYVSDFTDFSIYVDADPTLIESWFLERFELLLATAFQDPTNYYYPYAIGDHDEAIAKSKRVWRDIDLKNLEEYILPTRNRADMIIHKTFGHRIDRLLLRKY
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDH_PSET1
Sequence: MKALSKLKAEPGIWMTDAPKPEVGHNDLLIKIRKTAICGTDVHIYKWDEWAQKTIPTPMVVGHEYVGEVVDMGQEVRGFKVGDRVSGEGHITCGHCRNCRAGRVHLCRNTTGVGVNREGAFAEYLVIPAFNAFKIPDNISDELASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAAAVAKHVGARHVVISDVNEYRLELARKMGATRAVNVANEKLEDVIKELGMTEGFDIGLEMSGVPSAFNSMLNNMNHGGKVAMLGIPPSDMAVDWNQVIFKGLVIKGIYGREMFETWYKMASLIQSGLDLNPIITHQYSIDDFQAGFDMMISGQSGKVILNWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AEF1_DROME
Sequence: MMHIKSLPHAHAAATAMSSNCDIVIVAAQPQTTIANNNNNETVTQATHPAHMAAVQQQQQQQQQQQQQHHQQQQQQSSGPPSVPPPPTELPLPFQMHLSGISAEAHSAAQAAAMAAAQAAAAQAAAAEQQQPPPPTSHLTHLTTHSPTTIHSEHYLANGHSEHPGEGNAAVGVGGAVREPEKPFHCTVCDRRFRQLSTLTNHVKIHTGEKPYKCNVCDKTFRQSSTLTNHLKIHTGEKPYNCNFCPKHFRQLSTLANHVKIHTGEKPFECVICKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEDEG
What is the function of this protein?
Transcriptional repressor that binds specifically to fat body-specific enhancers, namely the adult ADH enhancer (AAE) and the enhancer that controls yolk protein gene expression.
What are the official names of this protein?
Adult enhancer factor 1, AEF-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRC_BIFLD
Sequence: MLGDSRDLFRPKTSDIPAKPGVYKWRDGEGRVIYVGKAKNLRNRLTNYFQPLYLLHPRTQTMVLTARSLEWTVVATELESLTLEYTWIKEFDPRFNVQFRDDKTYPYLAVSTGERIPRVWVTRSRKRRDTRYFGPYAKVWELRHSLDRLLRTFPVRTCTTNVFHKAQLTGRPCLFASIGKCSAPCVNRIEADEHRRLCEQLVGVMTGRLGRPYIAQLTRDMKEASAELEFEKAARLRDQIQMLETVVQQNAVVFDQDVDADVFGFASDELEASVHAFYVRAGSIRGERNWSVERVEDIDDADLMADLLVQVYSDAAGDNHPQSAATISTNREAIGSTQTITATDAVARAQATRERNTRQETTGRADLLAPIAPVPREIIVPVEPARREELEGWLTNLRGGAVTIRVASRGDKKQLMDRANENASQALQRSKMSRISDMGARTQAMNDVAKALGLAEAPLRIECYDISNTVGGAFQVASMVVFEDAIAKKSEYRRFAIRGKDGKGAVDDLSALYETLTRRFKHGNIAGDSGESIDAEQRVASAAGKMTTAVAAETIAANGNDNGEGGSDISGKGHAVPVGVQNDARESPPDIVQQNTNRHHFAYKPNLVVVDGGKPQVMAAAKALEDCGVNDVAVCGLAKRLEEVWVPDDDYPIILKRQSEGMYLLQRVRDESHRFAITYHRQQRRKGALRSALDEIPGIGESYQKRLLNHFGSVKAMREASVEDFEKVKGIGHAKAEALYTALHEQ
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_ACICJ
Sequence: MSRYVGAIDQGTTSSRFIVFDKGGNIVSVAQKEHRQIYPKPGWVEHDPMEILSNTNEVIGAALARANLTASDLAAVGITNQRETTLLWDRKTGQPLCNALVWMDTRTDQLVQQFTRDGGQDRFRAKTGLPLATYFAGLKLRWILDNVEGAKAKAEAGDALFGTVDSWLTWNLTGGVNGGHHVTDVTNASRTMLIDLATCAWDDDMLNAFGIPRACLPKIVPSSAVYGEIRTAPLQGTKLAGMLGDQQAALVGQTCFAPGEAKNTYGTGSFLLMNTGTEPVQSKAGLLTTLAYQLGDEKPRYALEGAIAITGALVQWLRDNLKLFDVAPQIEPLARSVEDNGDVYIVPAFSGLYAPYWKDDARGVIAGLTRYATRAHLARAALESTAYQVRDVVEAMQEDSGIRLAALKTDGGMVANELLMQFQADILNAPVVRPKMTETTALGAAYAAGLAVGYWANLEDLRANWGVDKTWEPSMPAETREKYYRSWKKAVQRSFAWVD
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: GSA_CAMHC
Sequence: MSNHKEFSEALKVIPGGVDSPVRAFKNVGSEPFMVQKGKGAYIYDIEGNKYLDFVQSWGPLIFGHADKDIQDAVIKTAKSGLSFGASSPLETKLAKLILSKFDWLDKIRFVSSGTEATMSAIRLARGFSGKDKIIKFEGCYHGHSDSLLVKAGSGATTFGSSSSAGVPEDTAKNTYLAIYNDIDSVKNIVEKEDIGTIIIEPIAGNMGLVPADKEFLIKLRKICDEKKIVLILDEVMSGFRAGELGSYGIYGIKGDIVTFGKVIGGGMNVAAFAGKKEIMDMISPLGPVYQAGTLSGNPVSMAAGIASLTKIFASRNLYTKLENLANMFMIGLKNIAKNHGIAIQVAVRGSMFGYFFTDKAVKNYNDALSADTKMFAKFHSGMIKEGIFLAPSQFETGFICDAMSEKEINFALKKANKVFDEISKDSAKKANKTKICSKKTVKKSVKNKK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_LACJO
Sequence: MKVIFIKDMKGKGKRGEVKNVPDGYAQNFLIKNGYAKEATSSNLNTLKRVQKAEKDAYEAEKAAAEDIKKKLEDDKTIVNFKSKAGTDSRLFGSISSKKIVEGLEKQYGIKVDKRKLELPEPIKSLGYTNVPVKLFKGVEAVIRVHITEQD
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: SYE_STAA2
Sequence: MSDRIRVRYAPSPTGYLHIGNARTALFNYLYAKHYNGDFVIRIEDTDKKRNLEDGETSQFDNLKWLGLDWDESVDKDNGYGPYRQSERQHIYQPLIDQLLAEDKAYKCYMTEEELEAEREAQIARGEMPRYGGQHAHLTEEQRQQFEAEGRQPSIRFRVPQNQTYSFDDMVKGNISFDSNGIGDWVIVKKDGIPTYNFAVAIDDHYMQISDVIRGDDHISNTPKQIMIYEAFGWEPPRFGHMSLIVNEERKKLSKRDGQILQFIEQYRDLGYLPEALFNFIALLGWSPEGEEEIFSKEEFIKIFDEKRLSKSPAFFDKQKLAWVNNQYMKQKDTETVFQLALPHLIKANLIPEVPSEEDLSWGRKLIALYQKEMSYAGEIVPLSEMFFKEMPALGEEEQQVINGEQVPELMTHLFSKLEALEPFEAAEIKKTIKEVQKETGIKGKQLFMPIRVAVTGQMHGPELPNTIEVLGKEKVLNRLKQYK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CECC_ANOGA
Sequence: MNFKLIFLVALVLMAAFLGQTEGRRFKKFLKKVEGAGRRVANAAQKGLPLAAGVKGLVG
What is the function of this protein?
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Cecropin-C, AgCecC.
What is the protein family that this protein belongs to?
Belongs to the cecropin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TWF1_XENLA
Sequence: MSHQTGIQASEDVLEMFARARNGKYRLLKLDIEDEQLTVSACEKPTRSWEQEYDNFILPLLEDKQPCYILYRLDSQNAQGFEWIFIAWSPDYSHVRQKMLYAATRATVKKEFGGGHIKEEIFGTVKDDISLKGYYKYLACQSAPAPLTTAEEELRQIKIKETPTDIAVDTKHQTLQGIAFPIEKAAFQALEQLREKRLNYVQLKIDIKNEIIILADTTNTEVRDLPKRIPKDAARYHFFLYKHSHEGDYLDSFVFIYSMPGYTCSIRERMLYSSCKNPLLDAIENRLLMEIARKIEIDNGDELTPDFLYEEVHPKQHAHKQNFAKPKGPAGKRGIRRLIRGPAEAETAND
What is the function of this protein?
Actin-binding protein involved in motile and morphological processes.  Inhibits actin polymerization, likely by sequestering G-actin (By similarity).
What are the official names of this protein?
Twinfilin-1.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL35_THEPA
Sequence: MEKLRVFELREKSDAELLKLLDDLKQELATFRVSKVTATGTSKLSKITLVRKAVAKVLTVYNQRKKEEARKKYKKLSKTPLNLRPKLTRAKRKALTTKQLTMKTIKERKRAENLPKRKYALLV
What are the official names of this protein?
60S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: CRYD_GIBZE
Sequence: MAGNKLLVYLLRRDLRATDNPILHHLATSDHGFTHLLPIYILPPHQIETSGFVVEGQKSPYPLAKSQVGRFWRCGPLRAKFQAECIWDVKKNFENIGSGMLIRIGKFDDVLKHLIKSLNEDHQSIDTVWMTEEPSKEELDDQTAVASVCSKEGIGFKLWHDEKYFIDDRDNGLKDPQDTPDVFTTYRKTQEPLRERPRPPLPRPQAGSLPSFPSWIPPQQAPFRIPDDYDEFERLLLEPVKAPIISDPPQFPEGAKSAHPFKGGETPAWDRLYHLIKSGAMTTYQETRNGLLGTEYSTKLSAFLAMGTITARSIHAELVKFEDGSEESYSRGFGFGKGENEGTRAVRFELLWRDYMRLCTFKFRTRLFKIDGFKGASGNYTKKWLTDREEDAEPDQNPTPAQVKDMIDRWIRGTTGMGLVDASQRELQLTGYTSNRARQNVASYLTKSLGIDWRLGAEYYEQSLIDYDTHSNWGNWQYQASCGNDPRSRSFNQVKQAFDYDQDGRFTRTWVNEVKSIDRLEHVFQICTCPKQELEKHGLSDNIMVTNPLKRIDFSVTKPRGNRRPYRWRKQGDRGRGGRGGRGGGTGNTSGNGDNRHNEPSPPNGGNRHNDFSPANGGSYMQGQPISGGYQQMAWRGNSHGLPSGRGYNSRQYMLDYSQQQQQPQHQLQHYYAHQQHQHPHPRQQQQQFYHQIPPHI
What is the function of this protein?
May have a photoreceptor function.
What are the official names of this protein?
Putative cryptochrome DASH.
What is the protein family that this protein belongs to?
Belongs to the DNA photolyase class-1 family.
Protein: RS7_STAAN
Sequence: MPRKGSVPKRDVLPDPIHNSKLVTKLINKIMLDGKRGTAQRILYSAFDLVEQRSGRDALEVFEEAINNIMPVLEVKARRVGGSNYQVPVEVRPERRTTLGLRWLVNYARLRGEKTMEDRLANEILDAANNTGGAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RSMH_CELJU
Sequence: MNQLPHVTVLLGEAVEALVSNPEGTYIDGTFGRGGHSALILQHLASEGRLLAIDKDLAAIATAREKFATDARFAIAHDSFASLKNLAAERGLVGRVQGILLDLGVSSPQLDEAERGFSFMQDGPLDMRMDQTRGPSAAEWVNTASEDEIAWVLREYGEERFAKRMARAIIAERQKRPFVRTGHLAEVIKAANPAWEKGKHPATRAFQAIRIQVNRELEDLEAVLAQAVDVLAPGGRLVVISFHSLEDRLVKRFIRQQEQGDPVPKGLPLREAQLNKTMRSLGKAMKASDQEVEANVRSRSAVMRVAEKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFA_SHEON
Sequence: MALTKAEMAEHLFETLGINKRVAKEMVESFFEEIRGALESGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPISARRVVTFRPGQKLKTRVEAANTGK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: ZDHC8_HUMAN
Sequence: MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAVPVYNGIIFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLVYVLNHAEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCCGNVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFIHTDLPEPPPSLTVQRDHPQLKTPPSKLNGQSPGLARLGPATGPPGPSASPTRHTLVKKVSGVGGTTYEISV
What is the function of this protein?
(Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER).  In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment.  Once the virus has formed, spike palmitoylation controls fusion with the target cell.
What are the official names of this protein?
Palmitoyltransferase ZDHHC8, Zinc finger DHHC domain-containing protein 8, DHHC-8, Zinc finger protein 378.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Protein: MNME_CLOK5
Sequence: MLEFDTITAIATVLGEGGISIIRISGENSLSIANSIFRGKNHRDLLDIKPYSMRYGFIIEKDTGEILDEVLVSFMKGPKSYTAEDIVEINCHGGVLATRKVMEEVIKAGARLAEPGEFTKRAFLNGRIDLSQAEAVIDIIRAKSHISVKSAVQQSQGKISKEINLLREELLEIIAHIEATVNYPEEDLEEMTSDQIYLKINKILDEINYILSNAEEGKIVREGLSVVIVGKPNVGKSSLLNSLIEENKAIVTDIPGTTRDVIEEYMNIGGIPIKIVDTAGIRKTDDIVEKIGVEKSKEKIDESDLVILMLDSSKELDEEDKEIINYVNHRKYIILLNKTDIGDKIDLNDICNLNSRFIIKTSIKNGEGLDKIKNCIKELFFKGEIKSEDLFITNTRHKEGLIRAKESCIEALQTLKSTLSIDLVSIDIKNAWINLGKITGDTLEEDIIDKIFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERP29_RAT
Sequence: MAAAVPGAVSLSPLLSVLLGLLLLSAPHGASGLHTKGALPLDTVTFYKVIPKSKFVLVKFDTQYPYGEKQDEFKRLAENSASSDDLLVAEVGISDYGDKLNMELSEKYKLDKESYPVFYLFRDGDFENPVPYSGAVKVGAIQRWLKGQGVYLGMPGCLPAYDALAGQFIEASSREARQAILKQGQDGLSGVKETDKKWASQYLKIMGKILDQGEDFPASELARISKLIENKMSEGKKEELQRSLNILTAFRKKGAEKEEL
What is the function of this protein?
Does not seem to be a disulfide isomerase.  Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
What are the official names of this protein?
Endoplasmic reticulum resident protein 29, ERp29, Endoplasmic reticulum resident protein 31, ERp31.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Melanosome.
Protein: MTNA_SYNFM
Sequence: MPQQWLPPIYWDGDAVAILDQRLLPQREAVIRCTSPKQVVAAIKNMAIRGAPAVGVAGAMALALGAVLIQAADARTFKSKFARLCRQVRTARPTGRNLGWAVDRIHALVEGNRDADVPRLHELIRREADLILAEDVAGNVAIGSWGKTVIPRGAGIMTYCNAGALATADYGTAVGVIRAAFDADPGIRVFSCETRPFLQGARLTVYELMKAGIPVTLITDNSIGSLMSRGMIDVVVVGADRIAANGDTANKIGTYMAAVLACTHGIPFYVAAPRSTIDASLPDGDGIPIEQRAPKEVTHFNGRRVAPQGAAALNAAFDVTPNKYITGIITEVGILSKPFGRAIRQALKA
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: TOP2_MIMIV
Sequence: MSKTSKSNKNPKSIEEKYQKKNLHEHILHSPDTYIGSIEEKTCNMWIFNESAGEDDAKIIFKEITYVPGLYKIYDEVIVNAADHNKRCQTCNIIKVDIDQKTGQISVWNNGDGIDVAIHKEHNIWVPSMIFGELLTSTNYDKNEEKTVGGKNGFGAKLANIYSVEFTIETVDANKGKKFFQRFTNNMYDKEEPKISSFKKSSYTKITFIPDFKKFGLKCLDDDTLALFKKRVFDLAMTTNAKVYFNDKQIVQNNFKKYVGLYFPEGSQHKVVIDDTTHERWKVGVIYDPTDQLEHQNISFVNSICTSRGGTHVEQVVGQIVNGLKTAIVKKAKNVQIKPAMIKENLIFFVDATIVNPDFDTQTKEYLTKKAANFGSKFEVTEKFIKGVIKTGVCDQIIANAKAREEANLSKTDGKGRGPVRYEKLYNAHKAGTKEGYKCTLILTEGDSAKTFAMSGLNVIGRDYYGVFPLRGKLLNVRDASPKKIADNEEITAIKKIVGLEQGKVYDDLKGLRYGSIMILADQDVDGYHIKGLIMNFIHCFWPSLVKYEGFIQSFATPLLKATKGKGKTKQVVAFTSPQSFEEWKKENNDGKGWSIKYYKGLGTSDPAEAQECFADLNDKLVKYFWEPKKKNLESESNSKSVDSNKSKTTNKKKIESEFIEEESDIISDTYKPKNKDISEDAMTLAFAGGREDDRKIWINTYNPDNYLDPSKKRISYYDFIHKELITFSVDDVLRSVPNLMDGFKPSHRKVFYGSVEKNIYKQEIKVSDLTGFVSNMTKYHHGDQSLSSTIVGMAQNYVGSNNLNLLMPLGMFGSRLTGGKDSASPRYLNTKLDDLAKKIFIDYDFDILQHQSEDNCRIEPVYYAPIIPMILVNGAEGIGTGYSTKIYPCNPRDIIANIKRLLTNENPKTMKPWFRHLTGTIEKIDGAKYISRAKYEIIGKDTIHITDLPVGIWTDNYKAFLDNLIVQGTAQNAEEKKASKAVSSAKNTKTTTKAGSKTGSRTRKNPALAKKSQKSVTAKVAKKNPVASSIKTYSEDCTDIRISFTIVFHPGKLDTLIKSGKLDTGLKLVKPLNLTNMHLFNEKGKIKKYDTYGAILRNFVKVRLNLYQKRKDYLLGKWKKEMDILKWKVKFIEYVIEGKIVIFKNGKSKKKEEVLKALEDLKFPKFIVGNESYPSYGYITSIGLFNLTLEEVEKLKKQLADKKQELAILEAKSPEEIWEEELDEFVEAYDIWEKEVDENYNDLLNKKKGSTGKKSRKTSTQK
What is the function of this protein?
Can introduce negative superhelical turns into double-stranded circular DNA.
What are the official names of this protein?
DNA topoisomerase 2, DNA topoisomerase II.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase family.
Protein: STE2_YEASX
Sequence: MSDAAPSLSNLFYDPTYNPGQSTINYTSIYGNGSTITFDELQGLVNSTVTQAIMFGVRCGAAALTLIVMWMTSRSRKTPIFIINQVSLFLIILHSALYFKYLLSNYSSVTYALTGFPQFISRGDVHVYGATNIIQVLLVASIETSLVFQIKVIFTGDNFKRIGLMLTSISFTLGIATVTMYFVSAVKGMIVTYNDVSATQDKYFNASTILLASSINFMSFVLVVKLILAIRSRRFLGLKQFDSFHILLIMSCQSLLVPSIIFILAYSLKPNQGTDVLTTVATLLAVLSLPLSSMWATAANNASKTNTITSDFTTSTDRFYPGTLSSFQTDSINNDAKSSLRSRLYDLYPRRKETTSDKHSERTFVSETADDIEKNQFYQLPTPTSSKNTRIGPFADASYKEGEVEPVDMYTPDTAADEEARKFWTEDNNNL
What is the function of this protein?
Receptor for the peptide pheromone alpha factor, the mating factor of yeast.
What are the official names of this protein?
Pheromone alpha factor receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 4 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL27_AKKM8
Sequence: MAHKKGQGSVKNGRDSRSKRLGVKKFGGQEVIAGNIIIRQRGTKWHPGKGVGMGRDYTIFSLVDGRVFFDREGRRVNVAPEGSEAAN
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SPEB_HALH5
Sequence: MRFDEAYSGKVFIMSRSNYEKSKAVIFGMPMDWTVSFRPSSRFGPNRIREASLGLEEYSPYMDKHLEEVAYFDAGDMLLPFGNPQRSLEMIESYVDKLLADQKMPIGLGGEHLVSWPIFKAMHKIYPDMAIIHIDAHADLREEYEGEPLSHSTPIRKACSLIGPENVYSFGIRSGMREEFQYAKDSGMYMAKFEVATPLKEVLPKLAGRNVYVTIDIDVLDPAFAPGTGTAEAGGISSKELLEAIVAIAHSDVNVIGADLVEVAPAYDPSEKTPIAASKFVREMLLGWV
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: EFTS_MYCCT
Sequence: MAVDAKLIKELREITQAGMMDCKKALEASDNNIDNAIVWLRENGLAKAAKKTDRVAAEGIALAKENDQKIVILEVNSETDFVAKNEKFLSLVDEIANALLSSNASSLEEGLQVKTNSGLTIEQSLISATATIGEKIALRRFELVNKTSGSSVIYNHANKRVSTLLVFDNKLDSTDAYNVAMHVAAMAPKYINMDQIPDDFKNAEMHIIKEQAKDDAKLQAKPANVLENILKGKLSKRLAEVSLLDQLFVIDESFKVGDFLKSKHVSLVKMIRYEVGEGIEKVVTNFADEVAAQLK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_PARD8
Sequence: MLRIAVQSKGRLYDETMMLLEEAGIKLNRGKRILLLSAKGFPVEVLFLRDDDIPQSVANGVADIGIVGENEYVEKGQEAKLIKRLGFSKCRLSLAIPKDEEYKGAEWFEGKTIATSYPAILRSFLEERGVKADIHVISGSVEIAPGIGLADAIFDIVSSGSTLVSNQLREVEVVLPCEALLIANNNLSKEKLEILDELLFRFEAIQVAEGKKYVLLNAPKEKLDEIIEVLPGMKSPTITPLANDEWVSVQSVIAEKHFWEIIGKLKSLGAEGILVLPIEKMIV
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_YERPE
Sequence: MIREERLLKVLRSPHVSEKASAAMEKNNTIVLKVAKDATKAEIKAAVQKLFEVEVEDVNTLLVKGKSKRHGQRVGRRSDWKKAYVTLKEGQNLDFIGGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: LEU1_AERS4
Sequence: MSDRVIIFDTTLRDGEQALAASLTVKEKLQIAQALERLGVDIMEVGFPVSSPGDFQSVQTIARHIKNSRVCALARALPQDIDAAGEALRVAEAFRIHTFISTSSIHVESKLKKSFEDVLEMGVSAIKHALRYTDDVEFSCEDAGRTPIDNLCRMVEAAIKAGARTINIPDTVGYTVPTEFSGIIQTLFNRVPNIDKAIISVHCHDDLGLSVANSIGAVQMGARQIECTINGIGERAGNCSLEEVAMILKTRADLLGVHTNIRHSEIHRTSALVSQLCNMPVQPNKAIVGANAFSHSSGIHQDGVLKAKNTYEIITPESIGLPQNNLNMTSRSGRHVIKHRMESMGYAESSYDLDHLYGKFLTLADKKGQVFDYDLEALAFFSQIHEEPEHFKLEYLGVQSGSSVLATASVKLKVGQDLVCEAATGNGPVDAVYQCINRITGYEIRIDKYALKAKGEGKNALGQVDIVAEYKGRKFHGMGLATDIIESSAQALIHVINSIWRADQVAEQMERNVTKTDKINTESV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.