PharMolix/UniProtQA huggingface dataset:
Protein: M2_I77AC
Sequence: MSLLTEVETPIRSEWGCRCNDSGDPLVAAASIIGILHLILWILDRLFFKCIHRRFKYGLKRGPSTEGVPESMREEYRQKQQSAVDVDDGHFVNIALE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: CLPL_STAAC
Sequence: MNNGFFNSDFDSIFRRMMKDMQGSNQVGNKKYYINGKEVSPEELAQLTQQGGNHSAEQSAQAFQQAAQRQQGQQGGNGNYLEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISVDISSLEAGTQYRGAFEENIQKLIEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDEYRNNILKDAALTRRFNEVLVNEPSAKDTVEILKGIREKFEEHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITAAHLSAQSPAVDKVETEKRISELENDKRKAVSAEEYKKADDIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPVSQMDDNDIERLKNISNRLRSKIIGQDQAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKDALIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVINFKNTIIICTSNAGFGNGNDAEEKDIMHEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLDKKGITMDVSQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDIDVEDNELVVKGK
What is the function of this protein?
Required for the development of induced thermotolerance.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpL.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpL subfamily.
Protein: SYY_BORA1
Sequence: MSQAEFPITPEVEADLRIARRGCDELLVESEFARKLARSRATGVPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSTIGDPSGRNSTRPPLTREQIEHNAKTYYAQASLVLDPARTEIRYNSEWCDPLGARGMIQLASRYTVARMMEREDFTRRFKTGVPIAVHEFLYPLMQGYDSVALKADLELGGTDQKFNLLVGRELQKEYGQEPQCILTMPLLVGTDGVDKMSKSKGNYIGISESPDSMFGKLMSISDTLMWRYFELLSFRSLEDIAALKAEIDAGRNPRDAKVALAQEIITRFHSAKDAEQALANFEARFRDGAIPDDIPEVNLAGAPMGILHVLRASSLCASSSEAQRAIEQGGVKIDGAKIEDRSLQLNAGSYVLQVGKRKFARVNLAV
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_PSYIN
Sequence: MMAKVESQTGDLNEKLIAVNRVAKVVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNIRDVQLKGNTLQHPIKGRHSGSKVYMQPASEGTGIIAGGAMRAVLEVVGVQNVLSKAYGSTNPINVVRATLDALENMNSPEQIAAKRGLSVNELLG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: OLF2_APILI
Sequence: KLWRMTGTWLGGFCHSIIQIPVIIQLPFCGPNVIDHYFRDLQPLFKLACTDTFMEGVIVLAFSGLFSVFSFLILVSSYIVILVNLRN
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor-like protein HbT2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ANPRC_RAT
Sequence: MRSLLLFTFSACVLLARALLAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHRELREDSIRSHFSVA
What is the function of this protein?
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP.  May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects.  May regulate diuresis, blood pressure and skeletal development.  Does not have guanylate cyclase activity.
What are the official names of this protein?
Atrial natriuretic peptide receptor 3, Atrial natriuretic peptide clearance receptor, Atrial natriuretic peptide receptor type C, ANP-C, ANPR-C, NPR-C.
What is the protein family that this protein belongs to?
Belongs to the ANF receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HIS8_METAR
Sequence: MIRARQSVQEIKEYVAGKNVEEVAASYGIDEKSIIKLASNESCLGASPLAIEAIRKAACDAHVYPSVDAIELREALAMRHGVPVRNIVCGNGMDAVIETLLRAFLETGDEVVIPLPAFSYYENVTRFCGATPKYCARRADFSLDVDAVLKQVTDRTKFIFITSPNNPTGNLTSLAEIRSVANAVDGIVFVDEAYIDFSGGKTALELMKECDNIVIGRTMSKAWGLAGMRIGYGFMPDWIFREYMKVATPFALSRIAIAAALAALKDEEHYNRTVETVKAERQFLMENVPFKVYPSEANFVLIDTAPLTSKHVVTEAMKRGVILRDCASFREMGDRYVRITVGTREQNVRLVEVLAEIKGSR
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: ATPE_SHESH
Sequence: MAAMTVQLDIVSAESRIYSGLVAHLQVTGSEGDLGVMPGHAPLLTHIKPGMARIVKQDGSEEVFYLSGGILEVQPFSVSVLADVVLRADEIDEQAAVEAKRRAETALADAGADFNYAAAAIELAQAIAQLRVVETIKKNIAR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PYRE_NEIG1
Sequence: MTDFRQDFLKFSLAQNVLKFGEFTTKAGRRSPYFFNAGLFNDGASTLQLAKFYAQSIIESGIRFDMLFGPAYKGIILAAATAMMLAEKGVNVPFAYNRKEAKDRGEGGVLVGAPLKGRVLIIDDVISAGTSVRESIKLIEAEGATPAGVAIALDRMEKGTGKLSAVQEVEKQYGLPVAPIASLNDLFILLQNNPEFGQFLEPVRTYRRQYGVE
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: BILF1_EBVB9
Sequence: MLSTMAPGSTVGTLVANMTSVNATEDACTKSYSAFLSGMTSLLLVLLILLTLAGILFIIFVRKLVHRMDVWLIALLIELLLWVLGKMIQEFSSTGLCLLTQNMMFLGLMCSVWTHLGMALEKTLALFSRTPKRTSHRNVCLYLMGVFCLVLLLIIILLITMGPDANLNRGPNMCREGPTKGMHTAVQGLKAGCYLLAAVLIVLLTVIIIWKLLRTKFGRKPRLICNVTFTGLICAFSWFMLSLPLLFLGEAGSLGFDCTESLVARYYPGPAACLALLLIILYAWSFSHFMDSLKNQVTVTARYFRRVPSQST
What is the function of this protein?
Constitutively active, ligand-independent G protein-coupled receptor that has immunoevasive and oncogenic activities (PubMed:34216564, PubMed:15596846, PubMed:15596837, PubMed:30647152).  Couples with the host inhibitory G protein (Gi) in order to disrupt the host chemokine signaling (PubMed:34216564).  As a consequence of its constitutive activity, mediates host CXCR4 inhibition (PubMed:20622011).  Enhances degradation of host major histocompatibility complex class I antigens via lysosomes, thereby modulating the antigen presentation to cytotoxic T cells (PubMed:19119421, PubMed:21123379, PubMed:23315076).  Targets selectively HLA-A, HLA-Band HLA-E molecules (PubMed:23315076).  Targets also newly synthesized MHC-I/peptide complexes en route to the host cell surface (PubMed:21123379).  Inhibits the host EIF2AK2/PKR phosphorylation (PubMed:15596837).  Displays tranforming activity (PubMed:20543866).
What are the official names of this protein?
G-protein coupled receptor BILF1, GPCR BILF1.
What is the protein family that this protein belongs to?
Belongs to the Epstein-Barr virus BILF1 protein family.
What are the subcellular locations of this protein?
Host cell membrane; Multi-pass membrane protein.
Protein: MNME_GEOMG
Sequence: MYLEDTIAAIGTPVGEGGIGIIRVSGPDVPAIARRIVRRVNENGDFVSHRFYYGTVVDPESRDTVDEVMAVLMRAPRSFTREDVLEIQCHGGYLVTRRVLDAVLQCGARPAEPGEFTRRAFLNGRIDLVQAEAVIDVIRSKTEAALNLAQHQREGRLSERLKAVQGCLRHSLALVEAFIDFPDDEVDPASRVEIEAKAREASGRIEELLEGFDEGRVLRDGVSVLIAGKPNVGKSSLLNTLLQEKRAIVTSVPGTTRDIIEEVVNVRGLPLRMLDTAGIRETEDVVEQEGVRLTLEKIPQADLILFVLDGSRPFDDDDRMILAALAERRVIVVTNKSDLPVTLRIPGELEGVHTVAISTATGAGIDDLREAVFETFIHGRAIDSREYVALSQTRHRDALVKARGRIAVFFANLAAGNDLEILAVDLRDALDAVGEVTGETTPDDILELIFQRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URK_HAEIN
Sequence: MSNPSCIIIAITGASASGKSSIASTVHKELCNELGCQEIGIITEDSYYKDQSHLEMTERVKTNYDHPNSMDRDLLIQHLKNLKNGSAVDVPVYSYVEHTRTNETTHFTPKRIVILEGILLLTDERVRQLADISVFVDTPLDICFIRRLQRDMEERGRSLQSVIDQYRATVRPMFLQFIEPSKQYADIVIPRGGKNRIAINMLKAQILHLLNQK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_YERPB
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKVGQTLLLHHVPNILSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNTYWKVRQAVETAKETLYTFDQLKSNKTEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIASGIKAAKDLGNMPPNICNAAYLASQARQLADAFSTNTVTRVIGEQQMKELGMHAYLAVGHGSQNESLMSVIEYKGNPNKDAKPIVLVGKGLTFDSGGISIKPAEGMDEMKYDMCGAATVYGVMRVVAELQLPLNVVGVLAGCENMPGGRAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPELVIDIATLTGACVVALGNHLTGLMSNHNPLAHELIGASEQAGDRAWRLPLGEEYYEQLDSNFADMANIGGRAGGAITAGCFLSRFTRKYSWAHLDIAGTAWRSGKNKGATGRPVALLSQFLLNRAGLNGDD
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_NITMU
Sequence: MLKIGIVGGTGYTGVELLRILSQHPEVNIEAITSRKEAGMDVAQLFPSLRGRIELKFSDPAEANLEKCDVVFFATPNGIAMKQVPSLLDAGVRIIDLAADFRIKDIAVWEKWYGMPHACPELVAEAVYGLPEINRDRIKTARLIANPGCYPTAVQLGFLPLVESGAADLDHLVADAKSGVSGAGRNAEIHTLFAEAADNFKAYGVSGHRHLPEIRQGLSQAAKHPVGLTFVPHLTPMIRGIHATLYVKLLKEVDLQALYENRYVNEPFVDVLPAGSHPETRSVRGSNLCRIAVHRPQGGDTAVILSVTDNLVKGAAGQAVQNMNLMFGLPETLAITHLPLFP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPO2_ORENI
Sequence: MELNDANLQTLTEFLRKTLDPDPTVRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIRVCAAVTFKNYIKRNWRIVEDEPNKISDPDRTAVKANIVNLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVARFRSGDFHIINGVLRTAHSLFKRYRHEFKSNELWSEIKLVLDTFALPLTELFKATIELCQTHATDVNALKVLFSSLTLIAKLFYSLNFQDLPEFFEDNMETWMTNFHGLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQPYLPRFVTAIWNLLVSTGQEVKYDLLVSNAIQFLASVCERPHYKHLFEDQNTLTSICEKVIVPNMEFRSADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTAIFSGYVNSMLSEYAKNPRENWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSPNVNEFPVLKADAIKYVMIFRSQLPKEQLLQAVPLLITHLQAESTVEHTYAAHALERLFTMRGPNNATLITAAEMAPFTEQLLNNLFKALAFPGSAENEYIMKAIMRSFSLLQESIVPYIPTLIGQLTHKLLQVSKNPSKPHFNHYLFESLCLSVRITCKANPTTVSSFEEALFPVFTEILQNDVQEFLPYVFQVMSLLLEIHSNSIPASYMALFPHLLQPVLWERTGNIPPLVRLLQAYLEKGGETIARSAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESLTQYRKQIFILLFQRLQSSKTTKFIKSFLVFVNLYCVKYGAIALQEIFDSIQPKMFGMVLEKIVIPEVQKVSGPVEKKICAVGITKVLTECPAMMDTEYTKLWTPLLQALIGLFELPEDDSIPDDEHFIDIEDTPGYQTAFSQLAFAGKKEHDPIGDAVGNPKILLAQSLHKLSTACPGRVPSMLSTSLNAEALQFLQGYLQAATVQLV
What is the function of this protein?
Export receptor for importin alpha.  Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity).  Negatively regulates fluid secretion and plays a role in fluid homeostasis by down-regulating cftr activity (By similarity).
What are the official names of this protein?
Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter.
What is the protein family that this protein belongs to?
Belongs to the XPO2/CSE1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: Y028_BUCAI
Sequence: MYRIIAVDLDGTLLTSENKITKYTKEIIQILIQKKFYFVFASGRHYIDIMKIKDSLKINIFIISSNGSKIYNLDNNLIFSDNLDENIASKLCRIKYSDKEIITQVYQNDQWYINNNKVENNFCSLLSSLQYKYFYPDDLNFKNISKIFFTSRNFQKLHILKRKIINFYGNKVHVNFSIPGCLEIVSGDHLKGYGLKLIANLLGVSLKNCIAFGDGMNDQDMLKVAGKAYIMKNSDPHLKIALPHLEIIESNDNDGVARCLNKIFIENNKEML
What are the official names of this protein?
Putative phosphatase BU028/BU029.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: ALLA_BRUA1
Sequence: MQIETLTVEPLTKEAFAPFGDVIEVEGAQLRLINNGTTERYHDLARMEAAGTQTRVLINIFRGQSFAAPIDIMMMERHPFGSQAFIPLNGRPFLVVVAEDAGAGPARPRAFLARGDQGVNYLRNIWHHPLLALEQKSDFLVVDRAGREDNLEEYFFSDYAYRIETTQTA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the utilization of allantoin as nitrogen source.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: EFP_NITEU
Sequence: MKTAQELRVGNVFMLGKDPMVVLKTEFTKSGRNSSVVKMKYKNLLTESPGEAVYKADDKFDIVVLDKKEVNYSYFASPMYVFMDAEFNQYEVEEETMSDALSFLEDGMPCEVVFYNDKPISVELPNTVVREIIYTEPAIKGDTTGKVLKPAKIPTGFELAVPLFCEIGDKIEIDTRTREYRSRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_SYNS9
Sequence: MADSEEWLEEWLTVGKIVGVQGLQGELRVNPASDFPERFTVPGPRWVRSKGSPPREMQLKTGRQLPGKSLFVVRLDSVDNRDAAEALVGSDWMVPADDRPQLGEGEFHLLDLVGLEARLSPDSDPIGTVTDLISGGNDLLEIKRTDGSKLLIPFVEAIVPEVHLKDGWLLLTPPPGLMDL
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_SHEPW
Sequence: MAITAAQVKELRDRTGAGMMDCKKALTETNGDIELAIDNMRKSGAAKAAKKAGNIAAEGAILIKNGEGFAALLEVNCQTDFVAKDANFLAFANSVLDVASAAKVSIEDLKAQFEETRVALVAKIGENINVRRVEYIDGANLAQYRHGERIGVVVAGEADEETLKHVAMHVAASKPEFVNPEDVPADLVEKEKALQIEIAMNEGKPAEIAEKMVIGRMKKFTGEISLTGQAYIMEPKKTVGAVLKEKGASVSNFIRLEVGEGIAKKEEDFAAEVAAQIAATKG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_BDEBA
Sequence: MKKTPLADTHEKLGARMVDFAGWYMPVQYIGLREEHNNVRTNVGLFDVSHMGEVRVKGPKALETLEWLTTNDVSKLNDGEAQYSLLPNDQGGLVDDIIVYCLSKDSDYLVCVNASNKDKDFAWMTKHNKGADITDESDLWGQIAIQGPKALELCDRVFDIKVSEMKSFTVKSGTFKGHKIMIATTGYTGEKGCEVFVEAAGTADLWMTLLEKGKDLGCMGIGLGARDTLRTEMKYSLYGHEIDDTTNPYEAGLGWVIKPAKKDFMNKAQIVGKKEAGLTRNLVGFKMLEKGIPRQGYSLFSFDNKEIGKVTSGTHSPTLDEPIGIAFIDVAYAKEGTEFLLDIRGRKVKAVVCKTPFVTK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MSBA_COXBU
Sequence: MKTLTSQGIRTYGRLLQATKQYWPIFLIGVVGMIAVSLSDAGFTWLIKPIINRGFIARDLVFIRWLPFIIVLVFLFRGAANFLSTYFINRVARNIVMDFRRAIFSHLLRLPAEFYDRHSSGHLLSTVIYNVEQVAQASSDALIITLQASSLVVGLLVVMFLVSWKLTLFFLVITPLIAWVMRVCSARLRHLSTSVQKSVGEVTHIASEAIEAYKIVRLYGGQKYENEKFRHATKLNQQRELKVVVTNSVGTSLVQLLIAIPIAIVLFFATQPSFHVTAGSFASIVSAMIMMLRPVRRLTMVNSYIQKGIAAAESIFKLLDEDVEKDRGERHLVRARGAIEYQGVSFAYDNSKKTILSEISFSIEPGQMVAIVGRSGAGKSTLINLLPRFYDASTGVIKIDDINIKEFRLQELRNQFGLVSQHTTLFNDTILNNIAYGQAGSIDKRKIIEAARAAHAMEFIEQLPEGLDTVIGENGVRLSGGQRQRIAIARALFKNAPIHILDEATSSLDTHSERHIQAALDNLMDQCTTLVIAHRLSTIERADWIMVLEEGRLIEKGTHQQLLTLNGAYAELYRMQFAEKPAAMTALDE
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPH_STRS2
Sequence: MTAQKMTAQEIIAFIGNAVKKTTVKVTFEGELAGAVPAEVTKLGNVLFGDWKDVEPLLANLTENVDYVVEQDGRNSAVPLLDKRNINARIEPGAIIRDQVTIGDNAVIMMGAVINIGAEIGPGTMIDMGAILGGRATVGKNSHIGAGAVLAGVIEPASAEPVRVGDNVLVGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQTQQKTALEEALRTL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: FZD1_HUMAN
Sequence: MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
What is the function of this protein?
(Microbial infection) Acts as a receptor for C. difficile toxin TcdB in the colonic epithelium.
What are the official names of this protein?
Frizzled-1, Fz-1, hFz1, FzE1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IL5_HUMAN
Sequence: MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
What is the function of this protein?
Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276).  Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity).  Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658).  Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138).
What are the official names of this protein?
Interleukin-5, IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF.
What is the protein family that this protein belongs to?
Belongs to the IL-5 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ROP1_RAT
Sequence: MPQTDKQVCIPPELPELLKQFTKAAIRTQPPDLIQWAAEYFGAMSRGEIPPVRERSEQVPLSNWAELTPELLKVLHSRVGGRLIIHADELAQMWKVLNLPTDLFNSVMNVGRFTEEIEWLKFLALACSSLGVTIAKTLKIVCEVLSCDHDGGPPRIPFSTFQFLYTYIAEVDGEISSSHVTRMLNYIEQEVIGPDGLIKVNDFTQNPRVRLE
What is the function of this protein?
Important for male fertility.  With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
What are the official names of this protein?
Ropporin-1, Rhophilin-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the ropporin family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.