PharMolix/UniProtQA huggingface dataset:
Protein: NDRG1_RAT
Sequence: MSRELHDVDLAEVKPLVEKGESITGLLQEFDVQEQDIETLHGSLHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAPSFPVGYMYPSMDQLAEMLPGVLHKFGLKSVIGMGTGAGAYILTRFALNNPEMVEGLVLMNVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEIHSNVEVVHTYRQHILNDMNPSNLHLFISAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDNSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLEGTRSRSHTSEGPRSRSHTSEGSRSRSHTSEDARLNITPSSGATGNNAGPKSMEVSC
What is the function of this protein?
Stress-responsive protein involved in hormone responses, cell growth, and differentiation.  Acts as a tumor suppressor in many cell types.  Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis.  Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath.  Required for vesicular recycling of CDH1 and TF.  May also function in lipid trafficking.  Protects cells from spindle disruption damage.  Functions in p53/TP53-dependent mitotic spindle checkpoint.  Regulates microtubule dynamics and maintains euploidy (By similarity).
What are the official names of this protein?
Protein NDRG1, N-myc downstream-regulated gene 1 protein, Protein Ndr1.
What is the protein family that this protein belongs to?
Belongs to the NDRG family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane (By similarity).
Protein: GMHA_MYCBO
Sequence: MCTARTAEEIFVETIAVKTRILNDRVLLEAARAIGDRLIAGYRAGARVFMCGNGGSAADAQHFAAELTGHLIFDRPPLGAEALHANSSHLTAVANDYDYDTVFARALEGSARPGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADFLINVPSRDTGRIQESHIVFIHAISEHVEHALFAPRQ
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCPR_EMENI
Sequence: MAQLDTLDVVVLAVLLAGSIAYFTKGTFWAVAKDPYASSGPAMNGVAKAGKSRNIIEKMDETGKNCVIFYGSQTGTAEDYASRLAKEGSQRFGLKTMVADIEEYDYENLDQFPEDKVAFFVLATYGEGEPTDNAVEFYQFITGDDVSFEGGGSAEDKPLSSLKYVAFGLGNNTYEHYNAMVRQVDAALTKLGAQRIGSAGEGDDGAGTMEEDFLAWKEPMWAALSEAMNLQEREASYEPVFCVTEDESLTPEDNSVYLGEPTKGHLEGQPNGPYSAHNPYIAPIVESRELFTVKDRNCLHMEISIAGTNLTYQTGDHIAIWPTNAGAEVDRFLNVFGLEEKRHSVINIKGIDVTAKVPIPTPTTYDAAVRYYMEVCAPVSRQFVSTLAAFAPDEETKTEIVRLGSDKDYFHEKITNQCFNIAQALQSITSKPFSNVPFSLLIEGLNKIQPRYYSISSSSLVQKDKISITAVVESTRLPGATHIVKGVTTNYLLALKQKQNGDPSPDPHGQTYAINGPRNKYDGIHVPVHVRHSNFKLPSDPSRPIIMIGPGTGVAPFRGFIQERAALAARGEKVGPTVLFFGCRKRDEDFLYKDEWKVFQDQLGDSLKIITAFSRESEKKVYVQHRLKEHAELVSDLLKQKATFYVCGDAANMAREVNLVLGQIIAAQRGLPAEKGEEMVKHMRSSGSYQEDVWS
What is the function of this protein?
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes.  It can also provide electron transfer to heme oxygenase and cytochrome B5.  Involved in ergosterol biosynthesis.
What are the official names of this protein?
NADPH--cytochrome P450 reductase, CPR, P450R.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Single-pass membrane protein; Cytoplasmic side. Cell membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: DISA_CUTAK
Sequence: MALLAPGTPIREGLDRIVNGRTGGLIVLGDGPEINGVCSGGFPLDVRLTPQALRELSKMDGGLVVSSDHERIKAAAVHFVPDGSLPTLETGTRHRTADRLSQQTGVPVVVVSASMSVMSLFLNGRRYLIERPEQLLARANQALATLASYRGRLVDEAENLTTLEIRDQVQVRDVAAVAQRVEMWRRIDAEVRGYVSALGVEGRLVQLQRNELSLGVEDLGRLLTDDYRPNSVAPGGFSLSGLQKLSWEDLLNVTMVAETINLGPAEHPLDSPIRARGHRQLTLMTDLSSRTIQRIIDHFSDLQSLVSASTSELGDIKGVGLRRAREIRQGLESIFEGDQRTHHH
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: HYPA_SHEHH
Sequence: MHEYSIVTALIEECERHAFANNASKVSRVEIKLGILSGVEPELLRTAFETFKLEGICREANLVMNIQPLVLRCLDCGQSTEHSERSVICSHCQSGQTKVLDGEDMMLMQLELEQA
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.
What are the official names of this protein?
Hydrogenase maturation factor HypA.
What is the protein family that this protein belongs to?
Belongs to the HypA/HybF family.
Protein: Y1229_XANC8
Sequence: MSVALTTLLLFVATAVAELVGCYLPYLWLRKGGSVWLLLPAALSLAVFVWLLTLHPAASGRVYAAYGGVYIATALLWLWWVDRVTPTRWDLLGAGCCLLGMAIIMFSPRSG
What are the official names of this protein?
UPF0060 membrane protein XC_1229.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOZ_MYCBO
Sequence: MSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQINDYYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLLEHTEGE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PLSB_MYCBT
Sequence: MTKPAADASAVLTAEDTLVLASTATPVEMELIMGWLGQQRARHPDSKFDILKLPPRNAPPAALTALVEQLEPGFASSPQSGEDRSIVPVRVIWLPPADRSRAGKVAALLPGRDPYHPSQRQQRRILRTDPRRARVVAGESAKVSELRQQWRDTTVAEHKRDFAQFVSRRALLALARAEYRILGPQYKSPRLVKPEMLASARFRAGLDRIPGATVEDAGKMLDELSTGWSQVSVDLVSVLGRLASRGFDPEFDYDEYQVAAMRAALEAHPAVLLFSHRSYIDGVVVPVAMQDNRLPPVHMFGGINLSFGLMGPLMRRSGMIFIRRNIGNDPLYKYVLKEYVGYVVEKRFNLSWSIEGTRSRTGKMLPPKLGLMSYVADAYLDGRSDDILLQGVSICFDQLHEITEYAAYARGAEKTPEGLRWLYNFIKAQGERNFGKIYVRFPEAVSMRQYLGAPHGELTQDPAAKRLALQKMSFEVAWRILQATPVTATGLVSALLLTTRGTALTLDQLHHTLQDSLDYLERKQSPVSTSALRLRSREGVRAAADALSNGHPVTRVDSGREPVWYIAPDDEHAAAFYRNSVIHAFLETSIVELALAHAKHAEGDRVAAFWAQAMRLRDLLKFDFYFADSTAFRANIAQEMAWHQDWEDHLGVGGNEIDAMLYAKRPLMSDAMLRVFFEAYEIVADVLRDAPPDIGPEELTELALGLGRQFVAQGRVRSSEPVSTLLFATARQVAVDQELIAPAADLAERRVAFRRELRNILRDFDYVEQIARNQFVAREFKARQGRDRI
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SIAS_DROME
Sequence: MLLNDIISGKLVDSVYIIAEIGQNHQGCVETAKKMIWEAKKAGCHCVKFQKSDLPAKFTRSALDREYISDHAWGKTYGEHKEYLEFSKDQYLQLQAHCKELNVDFTASAMDERSLEFLSALNVPFIKIGSGDANNFPLLKKAANLNLPLVISTGMQTMQTVERIVQTMRESGKEDYALMHCVSSYPTDPKDCSLQLISVLRTRFPNVAIGYSGHELGVIISQAAVLLGARIVERHFTLDKSQKGSDHRCSLEPQELKALTTAITNFKLSSVPMPPQEIVKKLNGDEELEAALQHVESKTILPCELPCRNKLGKSIVAARNLNKGYRLQLADMAIKVSEPSGLTAEDFLDLVGKELADNIGEDEPILGNSIIN
What is the function of this protein?
Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (PubMed:11886840, PubMed:21919466).  Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively (PubMed:11886840).  Essential for biosynthesis of sialic acids in neurons of the central nervous system (PubMed:21919466).
What are the official names of this protein?
Sialic acid synthase, N-acetylneuraminate synthase, N-acetylneuraminate-9-phosphate synthase.
Protein: RRF2M_BOVIN
Sequence: MSNLRIFAVNQKKISSLHYFNNMCSSKIRASLKRLKLHVLLGRNYSSLPGLIGNDIKSLHSIINPPIAKIRNIGIMAHIDAGKTTTTERILYYSGYTRSLGDVDDGDTVTDFMAQERERGITIQSAAVTFDWKGYRINLIDTPGHVDFTLEVERCLRVLDGAVAVFDASAGVEAQTLTVWRQADKHKVPRICFLNKMDKIGASFNYAVESIREKLKAKPLLLQLPIGEGKAFKGVVDVVRTEKLLWNPNSDDGKDFERKPLLEMSDPKLLKETTEARNALIEQVADLDDEFADLVLGEFSENFDLLPAEKLQTAIHRVTLAQTAVPVLCGSALKNKGVQPLLDAITMYLPSPEERNYEFLQWYKGDLCALAFKVLHDKQRGPLVFMRIYSGMLKPQTAIHNINGNCTERVSRLLLPFADQHIEIPLLTAGNIALTVGLKHTATGDTIVSSRSSALAASRRAKREGEKKQKENNEAERLLLAGVEIPEPVFFCTIEPPSMAKQPDLDHALKCLQREDPSLKVKLDPDSGQTVLCGMGELHIEIIHDRIKREYGLETYLGPLQVAYREAILNSIRATDTLDRTLGDKRHLVTVELEAKPVETSSLLPVIEYAASVAGDLSQASREAFENGVHSACLQGPLLGSPVQDVAVTLHSLVIHPGTSTTMISACVSRCLQKALKKADKQILEPLMNLEVTVSREYLSPVLADLAQRRGNIQEIQSRQDNKVVIGYVPLAEIMGYSTVLRTLTSGSATFALELSNYQAMNPQDQSTLLSQRHGLS
What is the function of this protein?
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.  Acts in collaboration with MRRF.  GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit.  Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
What are the official names of this protein?
Ribosome-releasing factor 2, mitochondrial, RRF2mt, Elongation factor G 2, mitochondrial, EF-G2mt, mEF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GUAA_SHEPW
Sequence: MSNIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVSEEQIRGFAPNGIILAGGPESVTADNSPRAPEYVFNAGVPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQVEVQTESALFKAIEDAVSETGKPLLDVWMSHGDKVSEIPDGFVTVANTETCPFAAMANEDKKFYGVQFHPEVTHTRQGKRMLEHFALDICGCDANWKPSSIIEDAVERLKKQIGDDEVILGLSGGVDSSVVAMLLHRAIGDKLTCVFVDNGLLRLNEAQQVMDMFGDHFGLNIIHVDAENRFLDAMAGEADPESKRKIIGHVFVEIFDEESKKCANAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRLADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: SRP68_HUMAN
Sequence: MAAEKQVPGGGGGGGSGGGGGSGGGGSGGGRGAGGEENKENERPSAGSKANKEFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLASAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQVVREELKPDQKQRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNENMAKGLQRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYANEVNSDAGAFKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDAHQTETSSSQVKDNKPLVERFETFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAFPPLEDKLEQKTKSGLTGYIKGIFGFRS
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957).  The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957).  The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957).  Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666).  The SRP complex possibly participates in the elongation arrest function (By similarity).
What are the official names of this protein?
Signal recognition particle subunit SRP68, SRP68, Signal recognition particle 68 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the SRP68 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Endoplasmic reticulum.
Protein: DJC11_PONAB
Sequence: MATALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGVDATDLFDRYDEEYEDVSGSSFPQIEINKMHISQSIEAPLTATDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTNCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGIQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAAVSIGVPQGVSLKVKLNRASQTYFFPIHLTDQLLPSAVFYATMGPLVVYFAMHRLIIKPYLRAQKEKELEKQRESAATDVLQKKQEAESAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSRKSEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMVLDSEALRIPKQSHRIDTDG
What is the function of this protein?
Required for mitochondrial inner membrane organization.  Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.
What are the official names of this protein?
DnaJ homolog subfamily C member 11.
What is the protein family that this protein belongs to?
Belongs to the DNAJC11 family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: IF2_RHOP5
Sequence: MVDTKNPGDKTLSVSPSKTLTLKPRVEQGTVRQSFSHGRTKQVVVEKRGKRRIGGEGGPADAPTAAAAAPAPAPAPVPSAAPRPAAPPPPSRPQQSRSQSPSRSGSGVVLRTLTEDERSARATALADARVRDEEERRAAEAEVARRNSAEGIAQAEREAAEARRKAEEERHRHEEEAKRKAELEAKRRFGEEEAKRPAAAATPAKSATPAARPTGAPAVRAPGVAAEAGDDDEGPRQVRRGPGGAARPVIPPKQPAAKPAPSKQRGRLTLVTALTADDVRERSIASFRRRTQRLKGHASNEPKEKLVREVIVPEAITIQELANRMSERAVDVIRMLMKQGAMHKINDVIDADTAQLIAEELGHTVKRVAASDVEEGLFDVVDNSTDTEPRSPVVTVMGHVDHGKTSLLDALRHANVVSGEAGGITQHIGAYQVTSPESGKKITFIDTPGHAAFTAMRARGAKVTDIVILVVAADDGVMPQTVEAINHAKAAGVPIIVAINKIDKPDAKPERVRTELLQYNVQVESLGGDTVDVEVSAKNKTNLDKLLEMIALQAELLDLKTNEQRPAEGTVIEAKLDRGRGPVATVLVQRGTLKVGDIIVAGAEMGRVRALISDQGDTVESAGPSVPVEVLGFNGPPEAGDRLAVVENEARARQVTSYRAHQKREKAASLTGGMRGSLEQMMSQLKTVGRKEFPLIIKADVQGSLEAILGSLEKLGTEEVAARILHAGVGGISESDVTLAEGFNAVILGFSVRANKEAAAAAKRNGIEIRYYNIIYDLVDDIKKAMSGLLAPTLRETMLGNALILEIFNISKVGKVAGCRVTDGTVERGANVRLIRDNVVVHEGKLSTLKRFKDEVKEVQSGQECGMAFENYTDMRAGDVIECYRVETIQRSL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2G_METM5
Sequence: MAASNQSEVNIGMVGHVDHGKTSLTRKLTGVWTDTHSEELKRGISIRLGYADCEIKKCETCDEPECYTVGKKCDSCGGKLVTLRKISFVDAPGHETLMATMLSGASLMDGAILVIAASEECPQPQTKEHLMALDALGVENILIVQNKIDLVTEEAAIENYNQIKEFTKGTVAENAPIIPVSAHHGANLDVLLKAIQEFIPTPERDETLTPKLYVARSFDVNKPGSEIKDLKGGVIGGSIIQGALKVGDELEIKPGIKVTEGNKTHWVPIVTKIISLGVGGKKLKSAVPGGLIGVGTELDPNLTKSDALSGSLAGLPGTLPETLEKMVIKPQLLERVVGSQDELVIEPLKTNEVLMLNVGTSTTVGVTASARADKAEIKLKLPVCADKGDRVAISRKIGSRWRLIGYGIIL
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit gamma, aIF2-gamma, eIF-2-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: TRHO_BURL3
Sequence: MTIVNLAAYHFVSLDTNEQWRPLVTARCNELGLRGTILLAPEGINLFIAGTREAADAFIAYLRHDPLFEGKFATLQFKESLSDSQPFRRMLVRLKREIITMKKPAIKPELGRAPFVDAQTLKTWLDRGHDDTGRPVVMLDTRNAFEVDVGTFDDALDYRIDKFSEFPEVIDANRADLEGKTVVSFCTGGIRCEKAAIHMKEIGIENVYQLEGGILKYFEEVGGAHYHGDCFVFDYRTALNPQLQPTENVTCFACRAVVTPEAQQSPSFVPGQSCPACAPAASAA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: ORN_PSEP1
Sequence: MQNPQNLIWIDLEMTGLDPDSDVIIEMATIVTDSELNTLAEGPVIAIHHSDEVLARMDEWNTRTHGASGLTQRVRESKVSMAEAEAQTIAFLEQWVPKGKSPICGNSICQDRRFLYRHMRNLENYFHYRNLDVSTLKELAARWAPDVRDSFKKGNTHLALDDIRESIAELRHYREHFIKL
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_LEGPA
Sequence: MADVTVKQLAQVVGIPVERLLNQLQEAGLSFTDDQQTVNEEQKRILLNHLKGSSNRDISAAPERITLRRKSMSQVTVGHDMHSGKTVNIEVRKKKTFIKRSAIPEQAEIEEPVVPPVVEEPVHEEITVVSEVSAETPELKETEEHPVIEPVAELDETVKEEEKISLEENTAESQDELTHANTDVIENLVDVVEEAIPASKKEEVKPEKVSKKKHLEQTDSDISEFKKGKKKPKYHTFEHDEEEQELHRRGGRSKFKKKKGTEKSDKYREAEETLTHGFALPTAPIVREVLIPETITVAELAKRMSVKAAEVIKVMMSLGAMATINQVIDQETSVIVVEEMGHKPVIIKEDAVETGLGEAISKGTKTEGRAPVVTIMGHVDHGKTSLLDYIRRTKVAAGEAGGITQHIGAYHVSTPKGNITFLDTPGHAAFTAMRARGAQATDIVILIVAADDGVKPQTIEAIQHAKAAKVPIIVAINKMDKPDADPERVMNELSVQEVIPEAWGGDTMFVNISAKSGMGIDDLLDAILLQSEVLELKAVTDGAAKGVVIESRLDKGRGPVATVLVQSGTLHKGDILLAGFQYGRVRALVSDNGDLVDSAGPSIPVEVLGLSAIPHAGDEAVVVPDEKKAREVALFRQGRFRDVKLARRQKTSIEGIMENMTATESKVLNIVLKADVQGSLEAISDALTKLSTDEVKVEVISSGVGGITESDVHLAIASNAILIGFNVRADGTAKRLAEQESVSIHYYSVIYDIVDQIKGALTGMLAPQFKEEIVGIAEVRDVFKSPKIGAIAGCMVIEGVVKRNNPIRVLRSNVVIYEGTLESLRRFKDDVLEVRQGFECGIGVKNYNDVKPGDLIEVFETVEIKRDL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTXI1_MESEU
Sequence: MCMPCFTTRPDMAQQCRACCKGRGKCFGPQCLCGYD
What is the function of this protein?
Toxin with unknown function in healthy organisms.  On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells.  This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).  Has been shown to weakly inhibit TRPV1 channels (PubMed:29483648).
What are the official names of this protein?
Insectotoxin-I1.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: HPA2_YEAST
Sequence: MSNTSEDNITVRFVTENDKEGWQRLWKSYQDFYEVSFPDDLDDFNFGRFLDPNIKMWAAVAVESSSEKIIGMINFFNHMTTWDFKDKIYINDLYVDENSRVKGAGGKLIQFVYDEADKLGTPSVYWCTDESNHRAQLLYVKVGYKAPKILYKRKGY
What is the function of this protein?
N-acetyltransferase that acetylates histone H3 at 'Lys-14' and histone H4 at 'Lys-5' and 'Lys-12'.  Also acetylates polyamines like putrescine, spermidine and spermine, and certain other small basic proteins like nuclear HMG proteins.
What are the official names of this protein?
Histone acetyltransferase HPA2.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. GNAT subfamily.
Protein: RS4E_SACS2
Sequence: MAHITRFEAPWFLMISKKQYKWTVRPNAGPHSIEKSIPLAVVIRDYLKLAGTIREAKHIIFDGKVLVDGKVRKDYKYPVGLMDIVSIPSADLYFRVLPDNVRFMRFSKISADEARYKYVRIINKTTIKEGRIQLNLEDGRNILVDKETAKNFKTLMTLKIELPSQQILDSFTISERSYAIFVGGRNVGIHGIVKNINLSKFKSRKYSVITLESRDGNTYQTNIMNVMSIGREKSDLRVD
What are the official names of this protein?
30S ribosomal protein S4e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: THIC_HALH5
Sequence: MSKSTIDLKQLSIQSSFPNSQKRYVTGSRSDIRVPFREISQHPTVTDSGEAENEPILVYDSSGPYTDESYEVNIEKGLPAIRKSWILERGDCEKYEGRDVRPEDNGFTKDDDPRAAREVFPRTSSHKPLRAKKGANVTQMHYAKKGIVTPEMEFVAIRENVSPEFVRDELARGRAILPSNINHPESEPMIIGRNFHVKINANIGNSAVSSSIAEEVEKMTWATRWGADTIMDLSTGKNIHTTREWIIRNSPVPVGTVPIYQALEKVNGVAEDLTWEVYRDTLIEQAEQGVDYFTIHAGVLLRYIPLTAKRVTGIVSRGGSIMAQWCLYHHKENFLYTHFEEICEIMKTYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTKIAWEHDVQVMVEGPGHVPMHQIKENMDKQLDICQEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAMLCYVTPKEHLGLPNKDDVREGVITYKIAAHAADLAKGHPGAQKRDDALSKARFEFRWRDQFNLSLDPERAMEFHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRTYAKEQGLDTEEAIEKGLEEKADEFKQAGGNLYR
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: AROC_PARDP
Sequence: MSFNTFGRVFTFTTWGESHGPALGATVDGCPPGVALDEGWIQQFLDRRRPGSSKFTTQRQEPDRVRILSGVFEGRTTGTPIQLMIENTDQRSKDYGEIAQAFRPGHADIAYHLKYGIRDYRGGGRSSARETAARVAAGGVAQAVLRDLVPGLKIAGYMVQMGDLHLDRANFDLAEIGNNPFFLPDAGAVPAWEDYLNAIRKAQDSVGAAVEVLIQGCPPGLGAPVYAKLDTDLAAAMMSINAVKGVEIGEGMAAAALTGTANADEIRMGNEGPRFLSNHAGGILGGISTGQDIVVRFAVKPTSSILTPRRTINRKGEEIELITKGRHDPCVGIRAVPIAEAMAACVVLDHLLLDRAQTGGRRGTIG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PSTB_MARMM
Sequence: MTDTPQNPTADLPIKVTARNVTVSYSGKQALHDVSIDIPDRSVTAFIGPSGCGKSTFLRCLNRMNDTIDGAVVGGSLTIDGQEINDKTIDPVVLRASVGMVFQKPNPFPKSIYDNVAYGPRIHGLALTRPELDEIVENALRKAGLWNEVSDRLNHPGTGLSGGQQQRLVIARAIAVNPEVILMDEPCSALDPIATARIEELIDELRENYCIIIVTHSMQQAARVSQHTAFFHMGNLVEYGPTEDIFTNPRDTRTQDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.