PharMolix/UniProtQA huggingface dataset:
Protein: CAF20_LODEL
Sequence: MAKYTEEQLFAIKEETSYVPQPQILSAFNELIEQVKEHAHQQQLQYQQQQQQQQGFSGIGSGVSGPGAQKWRNGDTYIDEHGHERSYHHMNRRRPSRSNNGEKKPFFNKKKTEVVVDEDGWETFTPVQHAHRGSIGEDGSEEKSKFRDSVSGSSGSGAGAGAGAGAASGSAGGVRARPNNKNLGSSKQVDPRQIASTKQTRTFNAFEALEGNDDEDDDE
What is the function of this protein?
Acts as an inhibitor of cap-dependent translation.  Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).
What are the official names of this protein?
Cap-associated protein CAF20.
What is the protein family that this protein belongs to?
Belongs to the CAF20 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1016_METJA
Sequence: MEFSEWTKNKRKLNNLEELKRDIIEQFKEKNALDEGIVVMASGGKDSSTAIALAKDLGLNIEYLIHFYHRWSWDVSKKMVEKLSKKFDIPVIFYNITDELLKRTKGAKGSSICRICKNIMKDKAVDISKEKGIRIIMTGDSALEKVSGAVMNYLRDVYGEVVYNKMELTPVPQKYSKGKDKEVLFFRPLIRLACEDVLKLMDYYNIEIERAHEVGDKIGFWREGCCLQYADENALLNEKLFNELYKYNKIATEVAKKHGFRASIKLPSKKIMVVPKKDEYITLIKNALRDVDES
What are the official names of this protein?
Uncharacterized protein MJ1016.
Protein: MUTL_PASMU
Sequence: MAIKVLSPQLANQIAAGEVVERPASVVKELVENSLDAGATRIQIDIENGGSTLIRIRDNGIGIAKDELSLALARHATSKIASLDDLDNILSLGFRGEALASISSVSRLTLTSRPATQNEAWQVYAQGREMETTLQPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFAHIDEVIRRIALAKMAISFTLTHNGKIVRQYRSAHDRTQKLKRVAAICGDEFVQNALEIDWKHDDLHLSGWVAQPTFSRTQNDLSYCYINGRMVRDKIITHAIRQAYADFLSPEQYPAFVLFIDLNPNDVDVNVHPTKHEVRFHQQRLVHDFICQGISNALHSEQASLYQTNEACVSANYQVEESAQHEYRPSYSKPNRAAAGQNIFDSSTTTPSTALFQTNKKNTQNRPHFSTNIPATRISKTEQAAYSALLSNSEMATVLPQEDGALLERKTPSILKALALVENKALLLQQQQQFYLLSLQQLQRLKIELSLQRDPVLQQPLLIPIVFRLNPQQLTYWQQQKTFFTQIGFEFHENLGQQRITLNRVPSCLRQQNLQKCIIVLLSQPLDTFSHFLTTLCDVIELEQITVYADAVTLLTETEQLLNQKQAIRLSELFIELNWQAYLEKM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: ARP19_MOUSE
Sequence: MSAEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPGGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPAAAPDKTEVTGDHIPTPQDLPQRKPSLVASKLAG
What is the function of this protein?
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.  When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.  May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity).
What are the official names of this protein?
cAMP-regulated phosphoprotein 19, ARPP-19.
What is the protein family that this protein belongs to?
Belongs to the endosulfine family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUKB_SHIFL
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEVDLDELQIRLEEQNEVVAEAIERQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADSAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNSLNQLSEQCGEEFSSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLLGRDEAPSQAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: O3620_CONAE
Sequence: MSRLGIMVLTLLLLVYMATSHQDAGEKQATQRDAINFRWKRSLTRRTATEECEESCEEEEKTCCGEXDGEPVCARFCLG
What are the official names of this protein?
Conotoxin ArMSGL-0124.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O3 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LPP21_BOMMO
Sequence: MKFVVVFASCVLAVSAGVTEMSAASMSSSNKELEEKLYNSILTGDYDSAVRQSLEYENQGKGSIIQNVVNNLIIDGSRNTMEYCYKLWVGNGQHIVRKYFPYNFRLIMAGNFVKLIYRNYNLALKLGPTLDPANERLAYGDGKEKNSDLISWKSHYLVGEQHSVLQDPPTLSYNQYLKLSSTTDCNTQDRIIFGTNTADTTREQWFLQPTKYENDVLFFIYNREVQRVALKLGRIVDASGDRSGIWTRWMK
What are the official names of this protein?
Low molecular mass lipoprotein PBMHPC-21.
What is the protein family that this protein belongs to?
Belongs to the 30 kDa lipoprotein family.
What are the subcellular locations of this protein?
Secreted.
Protein: C560_CAEEL
Sequence: MINIPTAILCRLGARSSISRSFGTSIVTKSEAKTPIQKFGWEYLLKQRSKNRPIAPHLTVYQPQLTWMLSGFHRISGCVMAGTLLVGGIGFAVLPFDFTAFVDFIRSWNLPCAVTAVFKYIIAFPIIFHTLNGIRFLGFDLAKGVNNVGQIYKSGYLVSGLSAILALAIVFNSCQNKSNKTA
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).  Mediates resistance to enteropathogenic E. coli infection (PubMed:16091039).
What are the official names of this protein?
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b560 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS17_AERHH
Sequence: MTDKIRTLQGRVISDKMDKSITVAIERKVKHPIYGKIIKRTTKLHVHDENNECKAGDLVEIRECRPLSKTKSWTLVAVVEKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: CLSA_ECO27
Sequence: MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWQRVAERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURG_MARN8
Sequence: MTDSPRRRFLMMAGGTGGHVFPALATARALQQRGHEVHWLGASGGMEERLIGDTDIPLSLIHISGLRGKGKLALLLAPFRLMRALGEAYTHLRRIRPDCVVGMGGFVTGPGGIAAWLMRKPLVIHEQNAIAGMTNRWLTRFSETVLEAFPGSFGDQTVTRCTGNPVRGEVASMDEPEQRLAGRSGKLRVLVVGGSLGAQVFNQQLPQALALMPEADRPDVRHQCGEKNLEAAQAAYEEAGVNASVEPFIRDMAEAYGWADLVICRAGALTVSELCAAGIGAILVPFPHAVDDHQTRNGQHMVKAGAAILVPQPRLTPEVLAETLKDLATDRKRILTMAKAARSLARPDATERVVNYCLEAANG
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: URK_ERWT9
Sequence: MADKSHQCVIVGIAGASASGKSLIASTLYREVRERVGDENIGVIPEDAYYKDQSHLTMEERVKTNYDHPSAMDHSLLLQHLQMLKAGQAIDLPVYSYVEHTRTQKTIRLEPKKVIILEGILLLTDARLRQEMNFSIFVDTPLDICLMRRMKRDVNERGRSMDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKINQFFE
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_STRTD
Sequence: MTLQETIIAQLGVKPSINPKEEIRKSVDFLKAYMIKHPFLKTYVLGISGGQDSTLAGRLAQLAVEELRAETEKDYQFIAIRLPYGVQADEDDAQRALAFIKPDVSLTINIKEAVDGQVAELAKAGVNVSDFNKGNIKARQRMITQYAVAGENSGAVIGTDHAAENLTGFFTKFGDGGADILPLFRLNKRQGAALLAELGADKALYEKVPTADLEEDKPGIADEVALGVTYHEIDDYLEGKEVSAKAQETIETWWRKGQHKRHLPITIFDDFWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: MIDN_XENTR
Sequence: MEQQPSVPRSCTNVARETPMNLNIQSTTGTRYELSVPPDETVDGLKRRISQRLKVPKERLTLLHRETRLSSGKLQDLGISDGSRLTLLPSVEAGLMSQMSRPEQSVMQALESLTETQVNDFLSGRSPLTLALRVGDHMMFVQLQLAAQQSGASHLQHRHVITRGAEAGASPQYRTLHTSTSALSHLASCTPGSTPPTTLSPTASTHRDGPHSSPLTTSVFRSHGEGVAVSPCAEQVPCSSRGTEGTSSSASSRSRKPGAIIESFVNHAPGVFSGTFSGTLHPHCQDSAGRPRRDIGTILQILNDLLSATRHYQGMPPSLTTLRCHTQCASQARNPKATSPQSSEPQQTTHPVGHCQAQTRTCKPSGDRLRQTENRATRCKVERLQLLMHQKRLRRKARRDSRAPYHWMPTRKSSRTSSNSSTSSGEGSLEIDFEDSLWKPDVKAELNSEFVVA
What is the function of this protein?
Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4.  Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
What are the official names of this protein?
Midnolin, Midbrain nucleolar protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Nucleus, nucleolus. Note=Detected in the nucleus and nucleolus with no expression in the cytoplasm. However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus.
Protein: LEUC_BACFN
Sequence: MNTLFDKIWDAHVVTTVEDGPTQLYIDRLYCHEVTSPQAFAGLRARGIKVFRPEKVYCMPDHNTPTHDQDKPIEDPVSKTQVDTLTKNAADFGLTHYGMMDKRNGIIHVVGPERGLTLPGMTIVCGDSHTSTHGAMGAVAFGIGTSEVEMVLASQCILQSRPKTMRITVDGKLGKGVTAKDIALYMMSKMTTSGATGYFVEYAGEAIRSLTMEGRLTLCNLSIEMGARGGMIAPDEVTFEYIKGRENAPQGEEWDQAVQYWKTLKSEDDAVFDKEVHFDAADIEPMITYGTNPGMGMGITQHIPTTDGMNETTKASFLKSLDYMGFQPGEALLGKKIDYVFLGACTNGRIEDFRAFASIVKGHQKAEHVIAWLVPGSWMVDAQIREEGLDKILEDAGFAIRQPGCSACLAMNDDKIPAGKYSVSTSNRNFEGRQGPGARTLLASPLVAAAAAITGVIADPRELM
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: MSRA_CLOPS
Sequence: MKKIVLAGGCFWGVEEFLSRINGVVSTEVGYANGRTENPTYEDICTKNTYFAEVCLVNYDENIISLKELLAKFWTIIDPTSLNKQGNDVGSQYRTGIYYVEPSDLEEILNSKEELQKSYSKKIVTEVKPLENYYKAEEYHQKYLKKNPNGYCHIKLD
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: PRIM_HHV8P
Sequence: METTYRREALTVRVIFCTSGDSAETIADVLTGAPTSASFFSVLHDLFYSQILAPRVTLKLCLPARRPGNGTRCSPVLVLRTDASVASGFLGGRPLEASDIKYMLLSDQTAGLFKPLLEIIGGARAPPNQDACTFQSQVAWLRTKFVTALRKLYKMTPSPYWMLSAFGAQEAQFVLTSSFYFFEHTVVCTTETVSHLSRLFSPQQGQTLVSVTSHEELGQLYGTSPFRRRVPAFVAYVKEKLARDSLETEAIDRTIDQIRGKLMLSNQDLVHFIYISFYQCLNKRAFLRYSRQTSSSSALRELGEDPQLCGALHGEFRDHVQSYYHKKTYLSTYIDIRYVGGVLPDGYFGGSLVGERCVYWCGQSKDTASLLATISQQVPHLRLQNEFAGMLDVAALRGSDDGQFKEGLFSHSQALPLYRCEFLGKQFFTMLQEDGLERYWEQSVIFPGDQDWDMLSDKDLTYRIFYHDLSLSLPTLKEQLLVSRHEYFNPRLPVYRWVLDFDLPVCRDIDRTFEEVHSLCCSLREAILDIIQLLGPVDPRTHPVYFFKSACPPDEWRGEDVASTSFCRCHDKLGMRIIVPFPEGVCVVGSEPMVALTGILNRTIKLDPELVHRFPSIQKKGGPFDCGIYGRGRSVRLPHCYKVGLVGELCRLLKILVCHPAPNGKAQYVRRAFTLRELLHHSPGHSAGHVGRIIYSIMDRNENFLENKTISYLPAKIPHIFQRIETLSGRSIEDWLHSAVWDKAYDTICKFFPDEKAQQFSHVAFTQQGENIIQLRPRQGRHFLCINHNHKNKSKTVRVFLTLHSIRVSEVTVTLMSQCFASKCNNNVPTAHFSFVVPVGLAS
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: DF279_ARATH
Sequence: MCLVCIGVVMSARMQESKKGILLKPKTCNTNADCAKFCKGPIQNCLYHTCACVPGNPHCC
What are the official names of this protein?
Putative defensin-like protein 279.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: DONS_MOUSE
Sequence: MAVSVPGYSPSFKRPPETVRLRRKRSRDHGAAVPASLPEPAPRRAALAAGLPLRPFPTAGGRGGAAATIARRNPFARLDNRPRVSDEASEEPLRGPQGASGPLLDSNEENNLLWEDTSSHERTGTELSQSQRVSLSESDTWSSDGTELPVDWSIKTRLLFTSSQPFSWADHLKAQEEAQGLVQHCRATEVTLPQSIQDPKLSTALRCAFQQALVYWLHPAFSWLPLFPRIGADRKMAAKTSPWSADETLQHALMSDWSVSFTSLYNLLKTKLCPYFYVCSYQFTVLFRAAGLAGSSVITALISPTTRGLREAMRNEGIEFSLPLLEEIGHKKKVRDPSLESEEEQAVSDEDEEESFSWLEEIGVQDQIKKPDVISIKLRKEKHEVQMDHRPESVVLVKGLNTFKLLNFLINCKSLVATSGAQAGLPPTLLSPIAFRGASMQMLKARSSNVKTQALSGYRDKFSLDITGPVMPHALHSMSMLLRSSQRGSFSAGLYAHEPTAVFNVGLSLDKELDRKVAREDLANCGLHPKTLEQLSQRPVLGKSSLRSVEMSDYILSWRS
What is the function of this protein?
Replisome component that maintains genome stability by protecting stalled or damaged replication forks.  After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.
What are the official names of this protein?
Protein downstream neighbor of Son, Protein 3SG.
What is the protein family that this protein belongs to?
Belongs to the DONSON family.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes at DNA replication sites.
Protein: YACG_CITK8
Sequence: MSETITVNCPTCGKTVVWGEVSPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSEEQK
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: DUT_SHIFL
Sequence: MMKKIDVKILDPRVRKEFPLPTYATSGSAGLDLRACLDDAVELAPGDTTLVPTGLAIHIADPSLAAMMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISVWNRGQDSFTIQPGERIAQMIFVPVVQAEFNLVEDFDATDRGEGGFGHSGRQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RBFA_STRSV
Sequence: MANNFRTDRVGMEIKREVNEILQKKVRDPRVQGVTITDVQMLGDLSMAKVYYTIMSNLASDNQKAQTGLEKATGTIKRELGHNLKMYKIPDLTFVKDESIEYGNKIDQMLRDLEKK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNF1_GIBFU
Sequence: MLFFKSIASLAALVSLAVASPIESRQSATTCGSTNYSASQVRAAANAACQYYQNDDTAGSSTYPHTYNNYEGFDFPVDGPYQEFPIKSGGVYTGGSPGADRVVINTNCEYAGAITHTGASGNNFVGCSGTN
What are the official names of this protein?
Guanyl-specific ribonuclease F1, RNase F1.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease N1/T1 family.
Protein: IOVO_RHEAM
Sequence: FATVDCSDHPKPVCSLEYMPLCGSDSKTYSNKCDFCNAVVESNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: RL4_MYCUA
Sequence: MAAQNQSAQKDLEIQVKAPDGKVDGSVVLPAELFDVPANIALMHQVVTAQRAAARQGTHSTKTRGDVSGGGRKPYRQKGTGRARQGSTRTPQFTGGGVVHGPKPRDYSQRTPKKMIAAALRGALSDRARNGRIHAVTELVAGQTPSTKSAKTFLATITDRKQVLVVIGRDDQTGVKSVRNLPGVHILSPDQLNTYDVLRADDVVFSVEALNAYIAANTSEEVSA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PSBN_CUSGR
Sequence: MELATLVTLFLSGLLISFTGYALYTAFGQPSQQLRDPFEEHGNELK
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid membrane; Single-pass membrane protein.
Protein: ATPA_PROM0
Sequence: MVSIRPDEISSILKQQITDYDQSVSVSNVGTVLQIGDGIARIYGLDQVMAGELLEFEDGTEGIALNLEDDNVGAVLMGEALGVQEGSNVKSTGKIASVPVGEAMQGRVVNPLGQPIDGKGEIPTSDTRLIEEMAPGIIKRRSVHEPMQTGITSIDAMIPVGRGQRELIIGDRQTGKSAIAIDTIINQKGQDVVCVYVAIGQKSASVANIVEVLRERGALDYTVVVSAGASEPAALQYLAPYTGAAIAEHFMYQGKATLVIYDDLTKQAQAYRQMSLLLKRPPGREAYPGDVFYLHSRLLERAAKLSDAMGGGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLSADLFNSGLRPAINVGISVSRVGGAAQTKAIKKIAGTLKLELAQFDELAAFSQFASDLDEATQQQLERGKRLRELLKQPQFSPLNLAEQVAVVYAGVKGLIDEVPVEDVTKFATELREYLKLNKAEFIEEILKEKKLNDGLEATLKEVINEVKSSMLATV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: ATG17_VANPO
Sequence: MKIERFVNASRKTLVEAQVLCQDANSRISNARSSFSHWERSISKIRFLLNCLKNQGSFIKNCILKVGIEENLIEKEWTQSILVDLAKELKYWNSKINEQVRVLDSIENILDEDTKSESKNLGYFVSRDNLDILEKRLKEIPNVKYHIDNIRGQYNTMFKKVSNYLINKRLKSVQEYFLTNFENDSDDIKKLTTTLPSKLVSLEHDLADYLSSITNHYDQSKLLQTLKPADPDYTDLLEVVKNDNSELDGIVTLLRETVDEVDETLKTFLGIFNEIELKQKECNKLLFGVIEEFKINHEYLLIFNDISSLIDNFKETCIEDINNTRSLCIFYQKFEIGYQNLLFEIERRKTVAQKMTDIIKNCELELSKINEEDQKNRSEFLKLNGDYLPENIWPGKIDDFSPLYSLEYSIKEI
What is the function of this protein?
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation.  Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles.  Plays particularly a role in pexophagy and nucleophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 17.
What is the protein family that this protein belongs to?
Belongs to the ATG17 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: ITRY_LEULE
Sequence: QVLVDLDGDPLYNGMSYYILPVARGKGGGLELARTGSESCPRTVVQTRSETSRGLPARLASPYRILIGSNIPLTIEFQPQKPYSCHGHSSRSLQWKVEKTQMVKIASSDEEQRLFGPFQIQPYRNHYKLVYCESESRNHHDDCRDLGISIDDQQNRLLVVKNGDPLVVQFAKANRGGDD
What is the function of this protein?
Inhibits trypsin, plasmin, human plasma kallikrein, chymotrypsin and factor XIIa activity.
What are the official names of this protein?
Trypsin inhibitor, LTI, LlTI, Kunitz-type trypsin inhibitor LlTI.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PPAC_STRT2
Sequence: MSKIFVFGHQNPDSDAIGSSYGYAYLKRQLGVEAEAVALGTPNEETAFVLDYFSVNAPRVVESAQSEGVNQVILTDHNEFQQSISDIKDVEVIEVVDHHRVANFETANPLMMRLEPVGSASSIVYRMFKENNVEIPKDVAGLLLSGLISDTLLLKSPTTHASDPAVAEELARLAGVNLEEYGLAMLKAGTNLSSKSAEELIDIDAKTFELNGNQVRVAQVNTVDISDVLSRQAEIEEAINSSIKSNGYSDFVLMITDILNSNSEILALGSNTDKIEKAFNFVLENNHAFLKGAVSRKKQVVPQLTESFNV
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_ACIC5
Sequence: MSIKSDRWIREQALKGMIEPFSEKQVREGVISYGLSSYGYDLRVSNEFKIFTNVNSAIIDPKNFDERSFVTVEADSVIVPPNSFALARSIEYFRIPRDVLTICVGKSTYARCGIIVNVTPFEPEWEGYVTLEISNTTPLPAKVYANEGLCQILFFQGDEPCEISYADKKGKYQNQQGIVLPKL
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.