PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_CLOK5
Sequence: MDIKKRIDELRKIIEYHNDKYYNQDDPEITDYEYDKLYVELRNLENSHPEYKIQSSPTQKVGGTVKRELRKVKHDIPVVSLQDVFSKEEVYSFVEKITSEVTYPKFVVEKKIDGLTVVLRYYNGELKEAITRGDGSIGESVFENILQVKSIPKHIPSKLNYLEIRGEIYMTNENFIKVNEKQEEIGGKIFKNPRNLAAGTIRQLDTSIVKDRNLDIFIFNLEISEGKKFETHSETLEWLSNQGFDVSPNFKICETADEVWNAILDIEESRWDLGYSIDGAVVKVDNLNDRISLGMTSKVPKWTVAFKYPPEQKETVIEDIIVQVSRTGRLNPLALLRPVILANTTISKATLHNQDFIDSKDIRIGDTVIIQKAGDIIPEIIRSIPEKRPDWAKKYIIPDVCPVCNSKTIREPDGVDTRCSNPDCEAQSFRKIGYFVSKDAMNIVGFGQNTVEALMKDGYIKKISDIYILKNYKDALIEKGIIGKEKSVNNLLNAIELSKDNDIDRLITGLGIRNVGKQSAKILAGNFKSMDELAGAAYEQLIELEDFGPTTVPDILEFFNSNAYIELIKKLKEAGVNTISKTLQKKIDNRFLGKTFVITGTLPTMKRDEAAEIIQSFGGKVSGSVSKRTSFVLAGEEAGSKLTKAQQLGISIITEEDLKDMIK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: MURI_STRZP
Sequence: MDNRPIGFLDSGVGGLTVVRELMRQLPHEEIVYIGDSARAPYGPRPAEQIREYTWQLVNFLLTKDVKMIVIACNTATAVVWEEIKAQLDIPVLGVILPGASAAIKSSQGGKIGVIGTPMTVQSDIYRQKIHDLDPDLQVESLACPKFAPLVESGALSTSVTKKVVYETLRPLVGKVDSLILGCTHYPLLRPIIQNVMGPKVQLIDSGAECVRDISVLLNYFEINRGRDAGPLHHRFYTTASSQSFAQIGEEWLEKEIHVEHVEL
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: SAC7_ARATH
Sequence: METVDSRNKLHSRLRLWEFPDQYIIEPADGSGSSCLDISRVDASMKLIDQVPESNSVRVPKIRSIFGVVGMLKLLAGSYLVVVTESERVGSFLGHPIFKVTTLKVLPCDHSLKNSPEEQKKMETEFSKLLSVAEKTTGLYFSYEVNLTLSSQRLHEMGDESKSLPLWRQAEPRFLWNNYMLEVLIDNKLDQFLLPVIQGSFNSFETAIGRDIVDITLIARRCTRRNGTRMWRRGADLDGYVANFVETEQIVQMNGYTSSFVQVRGSMPFMWEQVVDLTYKPKFEIVQPEEAKRIAERHFLDLRKKYGSVLAVDLVNKQGGEGRLCEKYATVMQHITGDDIRYLHFDFHQICGHIHFERLSILYEQIEGFLEKNGYFLLNEKGEKMKEQLGVVRSNCIDCLDRTNVTQSMIGRKMLEVQLKRIGVFGAEETISSHLNFDEHYKILWANHGDEISIQYSGTPALKGDFVRYGHRTAHGVLKDGWSSLRRYYLNNFADGTKQDAIDLLQGHYIVAVSRDMAPVPQKGGLEAVANFPVALFVVLMSFWFATMSLKQTGSDYKHKHLFFSLLWTGICVGMAALVRANGRIFCNRPRLHKPRG
What is the function of this protein?
Phosphoinositide phosphatase that preferentially hydrolyzes PtdIns(4)P.  Regulates the accumulation of PtdIns(4)P on membrane compartments at the tips of growing root hairs leading to proper root hair development.
What are the official names of this protein?
Phosphoinositide phosphatase SAC7, AtSAC7, Protein ROOT HAIR DEFECTIVE 4, Protein SUPPRESSOR OF ACTIN 1C, AtSAC1c, Protein SUPPRESSOR OF ACTIN 7, SAC domain protein 7, SAC1-like protein AtSAC1c.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Associated to tip-localized membranes in growing root hairs (PubMed:18281508).
Protein: PLAS1_TOBAC
Sequence: IEVLLGSDDGGLAFVPGNFSVSAGEKITFKNNAGFPHNVVFDEDEIPAGVDVSKISMSEEEYLNGPGETYSVTLSEKGTYTFYCAPHQGAGMVGKVTVN
What is the function of this protein?
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.
What are the official names of this protein?
Plastocyanin A'/A''.
What is the protein family that this protein belongs to?
Belongs to the plastocyanin family.
Protein: RR2_NICTO
Sequence: MTRRYWNINLEEMMEAGVHFGHGTRKWNPKMAPYISAKRKGIHITNLTRTARFLSEACDLVFDAASRGKQFLIVGTKNKAADSVEWAAIRARCHYVNKKWLGGMLTNWSTTETRLHKFRDLRMEQKTGRLNRLPKRDAAMLKRQLSRLQTYLGGIKYMTGVPDIVIIVDQHEEYTALRECITLGIPTIYLTDTNCDPDLADISIPANDDAISSIRLILNKLVFAICEGRSSYIRNP
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HXK_EMENI
Sequence: MVGVGPKRPPSRKGSMSDVPQNLLEHIKHFEEIFTVDTATLKKIVDHFVNELTKGLSVEGGNIPMNVTWVLGFPDGKETGTFLALDMGGTNLRVCEITLTEEKGGFDIIQSKYRMPEELKTGEAEELWQYIVDCVEQFIQFHHENENLSKLPLGFTFSYPATQDYIDHGVLQRWTKGFDIDGVEGKDVVPPLEKVFKERGLPIKVAALINDTTGTLIASSYTDPAMKIGCIFGTGVNAAYMENAGSIPKLAHMNLPPDMPVAINCEYGAFDNEHIVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIFRLALVDILDTQPGLIFKDQDTSQLRIPYLLDSSFPAAIEEDPYENLIETAELVQNMLKIKATRSELELMRRLAELIGTRAARLSACGVAAICKKKNIESCHVGADGSVFTKYPHFKARGAQALREILDWAPSEKDKVTIHAAEDGSGVGAALIAALTLKRVKAGNTAGIRDAQAMLAMC
What is the function of this protein?
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively).  Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.
What are the official names of this protein?
Hexokinase.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
Protein: GUAA_PHOV8
Sequence: MQEKIIILDFGSQTTQLIARRVRELNTYCEIVPYNKFPHNDPSIIGVILSGSPFSVYDESAFKVDLSDIRGKYPILGICYGAQFMSYTNGGKVEPAGTREYGRAHLSTFDQENPLLKNVREHSQVWMSHGDTITAIPENFKIIASTDKVAIAAYQIKEEKVWGVQFHPEVFHSEDGTQLLKNFVVDICGGKQDWSAASFIETTVAELKAQLGNDKVVLGLSGGVDSSVAAVLLNKAIGKNLTCIFVDHGMLRKNEFKNVLHDYECLGLNVIGVDASQKFFSELAGVEEPEKKRKIIGKGFIDVFDEEAHKIKDVKWLAQGTIYPDCIESLSITGTVIKSHHNVGGLPEKMNLKLCEPLRLLFKDEVRHVGRELGMPEHLITRHPFPGPGLAVRILGDITPEKVRILQDADDIYIQGLRDWKVKDSDGNETSLYHQVWQAGVILLPVQSVGVMGDERTYERAVALRAVTSTDAMTADWAHLPYEFMAKVSNDIINKVKGVNRVCYDISSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: LRRC4_RAT
Sequence: MKLLWQVTVHHTWNAVLLPVVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEDRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSRVLLIDTGVYTCMVTNVAGNSNASAYLNVSSAELNTPNFSFFTTVTVETTEISPEDITRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVPVPSTDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAAASAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI
What is the function of this protein?
Synaptic adhesion protein.  Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins.  Organize the lamina/pathway-specific differentiation of dendrites.  Plays an important role for auditory synaptic responses.  Involved in the suppression of glioma.
What are the official names of this protein?
Leucine-rich repeat-containing protein 4, Netrin-G2 ligand, NGL-2.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Postsynaptic cell membrane. Note=LRRC4 and DLG4 are interdependent for synaptic localization.
Protein: TXC4B_CUPSA
Sequence: VYGMLFKFLAKKVAKKLISHVAKKQLQ
What are the official names of this protein?
Cupiennin-4b, Cu-4b, Short cationic peptide-4b, SCP-4b.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 08 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NQOR_BURO0
Sequence: MAKVLVLYYSSYGHVETMAQHIVEGAKSVPGVEVTLKRVPETIPVDQARAIGVKVDQAAPVATVDELADYDAIIFGTPTRFGNMAGQMRTFLDQTGGLWMKGALVGKIGSVFASTGTQHGGQETTITSFHTTLLHHGMVIVGVPYACSGLVNMNEITGGTPYGATTLAGADGSRQPSANELDIARYQGKHVAELASKLAS
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: YL162_YEAST
Sequence: MQHTLTRTASLPERSSSAHSAATALPALRRPPDSCETLVPLLCIFWFVFVSMSPLPPARANKSDNKGLISADRNNKATLLLTIPRCTSKSYTNDLSPLKMTLLSAGKHPRPFRQEHRC
What is the function of this protein?
Overexpression confers resistance to the antimicrobial peptide MiAMP1.
What are the official names of this protein?
Protein YLR162W.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RLMH_STAS1
Sequence: MKITILTVGKLKEKYWKQAIAEYEKRLSAYSKIEIIEVPDEKAPENMSDKEVEQVKEKEGQRLLAKVKQQSTVITLEIKGNMLTSEGLAKEIESRMTRGQSDFTFIIGGSNGLHKDVLDRSDYALSFSKMTFPHQMMRVILIEQVYRAFKIMRGEAYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMPB_CAEEL
Sequence: MTKWSPNGNPLSTIYLILSLFTLAHTAPTTQHSRTTTQLRLEDEDGGGGVDEDSIHFVKGQMEKYGYLKGIDHSSPQEFRQALMFFQEVLEVEQTGNVDEMTVEAASKPRCTQTDVRQEQTKRTKRFTLSKRAKWAHASGQSVTLKWYISDYTSDIDRLETRKVVEKAFKLWSSQSYIKNEKKVTLTFQEASSKDEADINILWAEGNHGDEHDFDGANGKIEGNKKENVLAHTFFPGYARPLNGDIHFDDAEDWEIDVDQVGHGSNKRFFPYVLAHEIGHALGLDHSQKADALMHPYYKNVPINEIQLDIDDKCGVIWNYGGASDFCLYVWLMSQIVEAHNSSAQNNHGVGSITSSRTNKKSFKSEGFFLFQLKFPHSTLTHTDDVVMREKDKRSYRGDSKIPKCSSNNSSQRTLAEKKLTLGLHLSEADAKRYTEMVCNFLAGLHMWRTNPNHHASESLEKEYKGVSQEMGTFSGKSIAVRRLIRHAEHQKERSEKGPLDPDYFDDDFFENFFMEYSK
What is the function of this protein?
Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:24957743).  Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol (PubMed:20600277, PubMed:24957743).
What are the official names of this protein?
Matrix metalloproteinase-B, MMP-B, MMP-H19, Zinc metalloprotease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: SYFA_LEPIN
Sequence: MNLSEELDSIYKEAIQKIGSSISEEDLDKNKNDFIGKKGKLTAVLKNVASLSIEEKKTVGQKANELSKKLETFISETKTSLKKKLFEKQAASEFFDVLRPLSKPSNGSLHPITQIQYEIEDIFASMGFSVMDGPEIETDTNNFGALNFTEDHPAREMQDTFYLENGNLLRTHTSAIQVRTLRKLKPPFRIIAPGRVFRYEEVDASHEHTFYQIEGMVVGKDISAANLIDTMQVLLSRIFEKEIKTRLRPGYFPFVEPGFELDISCLVCDGKGCPVCKQSGWLELLPCGLIHPNVLSHAGLDPKEWTGFAFGLGLDRLVMMRYGIHDIRYFQSGNLRFLKQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLB13_CAEEL
Sequence: MGQENSKCPHQSLAEKRYKVERPKTKKVSSGSATERCLSTQSDEKNAARRLTVSSCDVSAEDDLPEIKKLSVCEPNEDEATSMTNAAAAAGGAKSKCKHFLTRRERILLEQSWRKTRKTGADHIGSKIFFMVLTAQPDIKAIFGLEKIPTGRLKYDPRFRQHALVYTKTLDFVIRNLDYPGKLEVYFENLGKRHVAMQGRGFEPGYWETFAECMTQAAVEWEANRQRPTLGAWRNLISCIISFMRRGFDEENGKKKQYSYNVQGFSSNRARRSISPYAPGVH
What is the function of this protein?
Involved in oxidative stress resistance.
What are the official names of this protein?
Globin-related protein glb-13.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: S3AD_RHIRD
Sequence: MSNVRHHEGSVTIEISNQLSEVLSVIERHSGINVAGRAFVRSAVDGGLKPYSDIDLLVTVAVKLDETTRRALLNDLMEASAFPGESETLRAIEVTLVVHDDIIPWRYPAKRELQFGEWQRNDILAGIFEPAMIDIDLAILLTKAREHSVALVGPAAEEFFDPVPEQDLFEALRETLKLWNSQPDWAGDERNVVLTLSRIWYSAITGKIAPKDVAADWAIKRLPAQYQPVLLEAKQAYLGQKEDHLASRADHLEEFIRFVKGEIIKSVGK
What is the function of this protein?
Mediates bacterial resistance to the antibiotic spectinomycin and probably also to streptomycin.
What are the official names of this protein?
Aminoglycoside (3'') (9) adenylyltransferase, Streptomycin 3''-adenylyltransferase, SP-R.
Protein: MAFB_MOUSE
Sequence: MAAELSMGQELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRPCTRLQPAGSVSSTPLSTPCSSVPSSPSFSPTEPKTHLEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDGFRSAHHHHHHHHPHPHHGYPGAGVTHDDLGQHAHPHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHATAAATAAGGNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL
What is the function of this protein?
Acts as a transcriptional activator or repressor.  Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells.  Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation.  Involved in renal tubule survival and F4/80 maturation.  Activates the insulin and glucagon promoters.  Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element.  SUMO modification controls its transcriptional activity and ability to specify macrophage fate.  Binds element G1 on the glucagon promoter.  Involved either as an oncogene or as a tumor suppressor, depending on the cell context.  Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (PubMed:11823429).
What are the official names of this protein?
Transcription factor MafB, Maf-B, Kreisler, Segmentation protein Kr, Transcription factor Maf-1, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Maf subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PA2H_PROMU
Sequence: SLIELGKMIFQETGKNPVKNYGLYLCNCGVGNRGKPVDATDRCCFVHKCCYKKVTGCDPKKDRYSYSWENKAIVCGEKNPPCLKQVCECDKAVAICLRENLQTYDKKHRVTVKFLCKAPESC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that has almost no phospholipase A2 activity.  Is myotoxic (By similarity).  Displays edema-inducing activities (PubMed:2029535).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog, svPLA2 homolog, TMV-K49.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MURD_MYCTO
Sequence: MSGLPRSVPDVLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQITGYALVVASPGFSPAIPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAAGELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_CHRVO
Sequence: MAEITAKMVSDLRVATGLGMMECKKALVEAEGDFAKAEEILRIKSGSKASKMAGRLAAEGIIGSYVEGGVGALVEVNCETDFVAKDPTFIALANAAAKAVAIANPADVEALAAVEVDGQQVEEIRKAAIAKLGENMTIRRFVRYQTEGAISTYLHGAKIGVIVDFTGPEQVGKDVAMHVAASKPICVSKDQVSAETLDQERKIYSAQAAESGKPADIVAKMVEGRINKFLAEVTLLGQPFVKNPDVTVEKLLAEQKASVKAFAMFVVGEGIEKKVVDYAAEVAAAAKL
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIAM1_HUMAN
Sequence: MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTAASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKNSGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEGATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPTTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVSSFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICPKVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTSNPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIKETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI
What is the function of this protein?
Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities.  Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.
What are the official names of this protein?
Rho guanine nucleotide exchange factor TIAM1, T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1.
What is the protein family that this protein belongs to?
Belongs to the TIAM family.
What are the subcellular locations of this protein?
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.
Protein: SCPB_STRS7
Sequence: MTYLSQLEALLFVAGEEGLSLRQLVSLLELTPTALQQQLDKLSQKYKEDKESGLCLIESSRTYKLVTKECLAPLLKDYAKAPINQTLSRASLEVLSIVAYKQPITRIEIDEIRGVNSSGALSKLVAFGLVQEAGKKEVIGRPNLYATTDYFLDYMGINHLEELVDISSIAVEEQETTLF
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: CLPS_MYCBT
Sequence: MAVVSAPAKPGTTWQRESAPVDVTDRAWVTIVWDDPVNLMSYVTYVFQKLFGYSEPHATKLMLQVHNEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RL36_MOUSE
Sequence: MALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL36 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Note=Detected on cytosolic polysomes.
Protein: DSBA_SALTI
Sequence: MKKIWLALAGMVLAFSASAAQISDGKQYITLDKPVAGEPQVLEFFSFYCPHCYQFEEVLHVSDNVKKKLPKGTKMTKYHVEFLGPLGKELTQAWAVAMALGVEDKVTVPLFEAVQKTQTVQSAADIRKVFVDAGVKGEDYDAAWNSFVVKSLVAQQEKAAADLQLQGVPAMFVNGKYQINPQGMDTSSMDVFVQQYADTVKYLVDKK
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA.  Acts by transferring its disulfide bond to other proteins and is reduced in the process.  DsbA is reoxidized by DsbB.  It is required for pilus biogenesis (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein DsbA.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbA subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: HRCA_MYCBO
Sequence: MGSADERRFEVLRAIVADFVATQEPIGSKSLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLEDVKPLSSAERRAIQSFLESGVDLDDVLRRAVRLLAQLTRQVAVVQYPTLSTSTVRHLEVIALTPARLLMVVITDSGRVDQRIVELGDVIDDHQLAQLREILGQALEGKKLSAASVAVADLASQLGGAGGLGDAVGRAATVLLESLVEHTEERLLLGGTANLTRNAADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETASEQMVGTSMVSTAYGTAHTVYGGMGVVGPTRMDYPGTIASVAAVALYIGDVLGAR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: PUR7_BRUO2
Sequence: MNRRRRIYEGKAKILYEGPEPGTLVQFFKDDATAFNAKKHEVIDGKGVLNNRISEHIFTQLNRIGIPTHFIRRLNMREQLIKEVEIIPLEVVVRNVAAGSLAKRLGLEEGTILPRSIIEFYYKADALDDPMVTEEHITAFGWASPQEIDDIMALAIRVNDFLTGLFLGIGIQLVDFKMECGRLWEGDMMRIVVADEISPDSARLWDITTNDKLDKDRFRRDMGGLVEAYQEVARRLGIMNENDTPRPSGPTLVK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: EFTS_PROM2
Sequence: MGNITAKLVKDLRDKTGAGMMDCKKALNETEGNLDKALEWLRKKGIASAEKKSGRVAAEGSIGSYIHTGSRVGVLLELNCETDFVARGDIFQSLLKDVSMQVAACPNVEYVSIDEIPEDVVKKEKQIEMGRDDLSGKPEQIKEKIVEGRIAKRLNELVLLSQPYIKDSSLTVEELVKQAAAKIGENIKVRRFTRYTLGEGIEKNQMDFAEEVASMQTN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.