PharMolix/UniProtQA huggingface dataset:
Protein: CH10_LAWIP
Sequence: MNLKPLNDRVLVKRLESEEKTAGGLYIPDTAKEKPSRGEVVAVGPGKHTDDGKLIPMAVKAGDTVLFNKYAGTEVKLDGVEHLVMREDDILAVITGETGRK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMO_PSEPK
Sequence: MSTTPATPKVGFVSLGCPKALVDSERILTQLRMEGYEVVPTYEDADVVVVNTCGFIDSAKAESLEVIGEAIKENGKVIVTGCMGVEEGSIRDVHPSVLSVTGPQQYEQVVNAVHEVVPPRQDHNPLIDLVPPQGVKLTPRHYAYLKISEGCNHSCSFCIIPSMRGKLVSRPVGEVLSEAERLVKAGVKEILVISQDTSAYGVDVKYKTDFWNGRPVKTRMLELCEALSSLGAWVRLHYVYPYPNVDDVIPLMAAGKILPYLDIPFQHASPKVLKSMKRPAFEDRTLARIKNWREQCPELVIRSTFIVGFPGETEEDFQYLLDWLTEAQLDRVGCFQYSPVEGAPANDLGLAEVPDDVKQERWDRFMAHQQAISAARLQLRIGKEIDVLIDEVEEQGSVGRSFFDAPEIDGSVFIDGDHGFKPGDKVRCRVVDADEYDMWAEPI
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NB2_MYCSS
Sequence: MNARSTYPGDVAVTIPEVHPDLTALAPLLGTWSGKGSGEYPTIEPFDYTEEITFGHTGKPFLTYVQRTRAADDGRPLHAETGYLRAPTPNNVEWILAHPTGITEIQEGPLTADGDTLRMDLISTDIGRSESAKEVMAVGRSMQISGDTLTYTLRMAAVGRPLQHHLSAVLHRVSS
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase 2, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: DPH3_USTMA
Sequence: MPVSFYDEIELEDMSYDDEKDVFHYPCPCGDRFEITRQQLKDAEDVARCPSCSLIIRVVFDPIDFEDGDEDEAPVNTIDVASQAVAAAA
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1.  Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state.  Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM.  Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex.  The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
What are the official names of this protein?
Diphthamide biosynthesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the DPH3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GLO2_SALSV
Sequence: MNLNSIPAFQDNYIWVLTNDEGRCVIVDPGEAAPVLKAIAEHKWMPEAIFLTHHHHDHVGGVKELLQHFPQMTVYGPAETQDKGATHLVGDGDTIRVLGEKFTLFATPGHTLGHVCYFSHPYLFCGDTLFSGGCGRLFEGTPSQMYQSLMKINSLPDDTLICCAHEYTLANIKFALSILPHDSFINEYYRKVKELRVKKQMTLPVILKNERKINLFLRTEDIDLINEINKETILQQPEARFAWLRSKKDTF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: HISZ_BURCM
Sequence: MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLSGRTLGLRADITPQVARIDAHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAALLARDAQAAERGESLYDALSGKDVPLLNELTDDLGADTRAALRALPHLYGDASVLDEARARLPVLPEITRALDDLAQLAAQAKGVEVAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLRELARISPIEARGTAILAPWAQDDALGAAVAALRDAGEVVIQALPGHDHVLDEFACDRSLVERNGAWVVEPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1355_LACDA
Sequence: MTEADQVRKRINELYKKKQESGLTEAEEAERKELHKQFIANFRAGFKQQLDSLVIVDDQGKDVTPDKAKQIQKKKVLR
What are the official names of this protein?
UPF0291 protein Ldb1355.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRSA_SALPC
Sequence: MTQANLSETLFKPRFKHTETSTLVRRFNRGSQPPMQSALDGKNVPHWYRMINRLMWIWRGVDPREILDVQARIVMSDAERTDDDLYDTVIGYRGGNWIYEWAKQAMDWQQKACQEQDAMRSGRYWLHASTLYNIAAYPHLKGDELAEQAQALANRAYEEAAQRLPGSLREMEFAVPGGSPVTAFLHMPKGDGPFPTVLMCGGLDAMQTDYYTLYERYFAPRGIAMLTLDMPSVGFSSKWKLTQDSSLLHQHVLKALPNVPWVDHTRVAAFGFRFGANVAVRLAYLEAPRLKAVACLGPVVHALLSDPQRQSTVPEMYLDVLASRLGMHDASDEALRVELNRYSLKVQGLLGRRCPTPMLSGFWKNDPFSPEEESRLITTSSSDGKLIEIPFNPVYRNFDRALQEITDWINHRLC
What is the function of this protein?
Catalyzes the hydrolysis of esters.
What are the official names of this protein?
Esterase FrsA.
What is the protein family that this protein belongs to?
Belongs to the FrsA family.
Protein: ENP1_LYSSH
Sequence: MDILIRPGDSLWYFSDLFKIPLQLLLDSNRNINPQLLQVGQRIQIPGYVTTSYTITQGDSLWQIAQNKNLPLNAILLVNPEIQPSRLHIGQTIQVPQRLTWRLVNGQQNYDYSMMMNDIKKLQTAYPFLQGTPIGNSVLAQPIPEILIGNGSKRIHYKASFHANEWITTPIIMTFLNDYLLALTNQTTIRGLSMGPLYNQTTLSLVPMVNPDGVNLVINGPPANEALKNKLIAWNHNSQNFSGWKANINGVDLNDQFPAKWELENARNPQTPGPRDYGGEAPLTQPEAIAMADLTRSRNFAWVLAFHTQGRVIYWGFENLEPPESQTMVEEFSRVSGYEPIQSANSYAGYKDWFIQDWRRPGFTVELGSGTNPLPISEFDTIYQEALGIFLAGLYL
What is the function of this protein?
An endopeptidase which hydrolyzes the gamma-D-Glu-(L)meso-diaminopimelic acid bond of L-Ala-gamma-D-Glu-(L)meso-diaminopimelic acid and L-Ala-gamma-D-Glu-(L)meso-diaminopimelic acid(L)-D-Ala peptides.  It is active on spore cortex peptidoglycan.
What are the official names of this protein?
Gamma-D-glutamyl-L-diamino acid endopeptidase 1, Endopeptidase I, Gamma-D-glutamyl-L-diamino acid endopeptidase I, Gamma-D-glutamyl-meso-diaminopimelate peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
Protein: NFI_SULIA
Sequence: MVEKHLLEFLEKLQFLIAKNVKISHYGIENVKKICGVDIAYKGNLGFSVGVSMDINSGDYNYKSYVGEVNFPYIPGFLFMREAPLMIKAIEGLDCHLLLVDGHGIAHPRKSGIAAVIGVLLDFPTIGVAKSRLTGDLVNESEITYVYLNGEKVGVKFGRYFYSPGNKVDLQDCIELGKRGYPKVLKIADMLTKKTKKE
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_PSEPG
Sequence: MALERCDVEKIAHLARLGLNDGELPRITDALNSILGLVDQMQAVDTTGIEPLAHPLEASQRLRPDQVTESNQRDAYQAIAPSTESGLYLVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: MTNB_DROME
Sequence: MALSIFKDLPAEHPRHLIPSLCRQFYHLGWVTGTGGGMSIKYNDEIYIAPSGVQKERMQPEDLFVQDITGKDLQLPPEIKGLKKSQCTPLFMLAYQHRQAGAVIHTHSQHAVMATLLWPGKTFRCTHLEMIKGVYDEADKRYLRYDEELVVPIIENTPFERDLADSMYAAMMEYPGCSAILVRRHGVYVWGQNWEKAKTMSECYDYLFSIAVEMKKAGIDPEKFESS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Probable methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_DINSH
Sequence: MHAFRTHTCAELTKDAVGQTVRLSGWVHRVRDHGGVLFIDLRDHYGMTQVLCDPDSPVFSQVEKVRSEWCIRIDGTVKARDESLINPKIPTGEIEVFIRDMEVLGTAEELPLPVFGDQEYPEETRLKYRFLDLRRESLHDNIMLRSKVVQSIRKRMWDIDFTEFQTPIITASSPEGARDFLVPSRLHPGKFYALPQAPQQFKQLIMVGGFDKYFQIAPCFRDEDPRADRSPTDFYQLDLEMSFVSQQDVFDTIQPVIAGIFEEFGGGRRVDTDWPLISYRDSALWYGTDKPDLRNPIKMQIVSDHFAGSGFAIFAKLLEQEGTEIRAIPAPGGGSRKFCDRMNKFAQEQGLPGMGYIFWRDQGQGMEAAGPLAKNIGPERTEAIRQQLGLQVGDAAFFLGGKPASFEAVAGRARTVIGEELGLIDQDRFAFAWIVDFPMYEKDDEGRIDFSHNPFSMPQGGMAALEGDPLEVLGYQYDLACNGYELVSGAIRNHKLDIMYKAFEIAGYGADEVEKRFGGMVNAFKYGPPPHGGCAAGIDRIVMLLADTANIREVIMFPMNQRAEDLMMNAPSEPTGEQLRDLSLRVIPQE
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPA_SCHMA
Sequence: MATVQPIVNSHLSELDEDVFHHFGFTTKSFDFKEKFGDVKFVCVCGSSGRIHNFAISMAKLAGLALPVENIAGSHARFVLYKVDHILFADHGMGIPSALIMLHEVTKLLHYAGCKDVLFIRLGTSGGLGVKPGTIVLSDRCVNTKLEPYNELCILGKPVRRQTIVDLNTVNELKKLSENLSLECSVVVGGTIAANDFYEEQGRLDGSICTFSKEEKLAFLQSAYEHGIRNMEMEGTAITSHCYLTGHRAILVCVTAVNRLEGDQITISTDEFTLFAQRPGQLVGEYLKRNNGIIVR
What is the function of this protein?
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:26898674).  The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable).
What are the official names of this protein?
Uridine phosphorylase A, SmUPa.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: ESCA_APIME
Sequence: HQQFHCAAAEGQAKKSFSCKYCEKVYVSLGALKMHIRTHTLPCKCHLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCNRAFA
What are the official names of this protein?
Escargot/snail protein homolog.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARCA_SALCH
Sequence: MMEKHFVGSEIGQLRSVMLHRPNLSLKRLTPSNCQELLFDDVLSVERAGEEHDIFANTLRQQGIEVLLLTDLLTQTLDVADAKAWLLDTQISDYRLGPTFAADIRAWLADMPHRELARHLSGGLTYGEIPASIKNMVVDTHDINDFIMKPLPNHLFTRDTSCWIYNGVSINPMAKPARQRETNNLRAIYRWHPQFAGGDFIKYFGDEDINYDHATLEGGDVLVIGRGAVLIGMSERTTPQGVEFLAQALFKHRQAERVIAVELPKHRSCMHLDTVMTHIDIDTFSVYPEVVRPDVQCWTLTPDGRGGLKRTQESTLVHALEKALGIDQVRLITTGGDAFEAEREQWNDANNVLTLRPGVVVGYERNIWTNEKYDKAGITVLPIPGDELGRGRGGARCMSCPLERDGI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSRF_YERPN
Sequence: MADLDDIKDGKDFGIGIPQQNPAFTLKGSGSLDWGMQSRLARIFNPKTNRTVMLAFDHGYFQGPTTGLERIDINIAPLFEYADVLMCTRGILRSVVPAAANRPVVLRASGANSILTYLSNEAVAVAMEDAVRLNACAVAAQVYIGTEHEHQSIKNIIQLIDQGMRYGMPTMAVTGVGKDMVRDQRYFSLASRIAAEMGAQVIKTYYVDSGFERIAAGCPVPIVIAGGKKLPERDALEMCYQAIDQGASGVDMGRNIFQSDAPIAMLKAVHAIVHKNENAAAAYQLFLHEQN
What is the function of this protein?
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.  Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.
What are the official names of this protein?
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_BURO1
Sequence: MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLSAVQNVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVMCGFRVALGGAQTYYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGFYDALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFAERVPGSFAEVTKSNVERFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARRAFAALAA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
Protein: RL36_MYCGE
Sequence: MKVRASVKPICKDCKIIKRHRILRVICKTKKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LMIP_HUMAN
Sequence: MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAYWNATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR
What is the function of this protein?
Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization.  Acts as a receptor for calmodulin.  May play an important role in both lens development and cataractogenesis.
What are the official names of this protein?
Lens fiber membrane intrinsic protein, MP18, MP19, MP20.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: UBP33_HUMAN
Sequence: MTGSNSHITILTLKVLPHFESLGKQEKIPNKMSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDENNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQAEEKIEVETRSL
What is the function of this protein?
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling.  Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate.  Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling.  Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1.  Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2).  Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2.  Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2.  This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins.  Deubiquitinates DIO2, thereby regulating thyroid hormone regulation.  Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 33, Deubiquitinating enzyme 33, Ubiquitin thioesterase 33, Ubiquitin-specific-processing protease 33, VHL-interacting deubiquitinating enzyme 1, hVDU1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP20/USP33 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (PubMed:23486064). SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus.
Protein: HEM3_DESHY
Sequence: MGSVKIGTRDSQLALWQAEWVKRKLEEYYPEREFVLVPMKTKGDKILDVPLAKIGDKGLFTKELEVGLLNGEIDCAVHSLKDLPTVLPPGLEIAAFCEREEPRDVFLSKDGTPLGSLPAGSIIGTSSLRRKAQLQNYRSDLSFADLRGNLQTRWRKLQESDMAGIVLAAAGVKRLGWEDRITEYISEEIMLSAVGQGAIAVEIAAQRADVREMLDLLNHGDTERAVKAERALLYRLEGGCQIPIGAWAVTEQQQIVLKGMVASLDGQRILKVTLSGEHPEELGRQAADLLIAQGALEILQEIRTPLEK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: LEUC_POLSJ
Sequence: MGRTLYDKIWDEHVVHTEEDGTSILYIDRHLVHEVTSPQAFEGLREAGRKVWRISSIVATADHNTPTTGWELGYDGITDLVSKEQITTLDANIKEFGAAAFFPFLSKRQGIVHVIGPESGATLPGMTVVCGDSHTSTHGAFGALAHGIGTSEVEHVMATQTLLAKKAKNLLIKVEGTLPKGCTAKDIVLAIIGKIGTAGGTGYTIEFAGSAIRALSMEGRMTVCNMAIEGGARAGLVAVDQKTIDYVKGRLLAPTGVEWDQAVQYWATLHSDADAKFDAVVELDASQILPQVTWGTSPEMVLSIEDRVPDPDKEKDANKRGAIERALTYMGLQPGKALNDLYVDKVFIGSCTNSRIEDMREAAAIVKKLGQKVAKNVKLAMVVPGSGLVKEQAEREGLDKIFVAAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAVHGHFVDVRKFV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: PGK_ACTSZ
Sequence: MSVIKMTDLDLAGKRVFIRADLNVPVKDGKVASDARIRATIPTLKLALEKGAKVMVTSHLGRPTEGEFKPEDSLQPVVDYLNNAELGVPVRLVQNYLDGVDVQAGEIVVLENVRVNKGEKKNDPELGKKYAALCDVFVMDAFGTAHRAQASTYGVAEYAPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHNVGKSLYEEDLIPEAKRLAAATNIPVPVDVRVGTEFSESAPATEKSVTEVRADESIFDIGDKSAEELAKIIKSAKTILWNGPVGVFEFPNFRKGTEVVSNAIAEATANGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILEKRANG
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIM15_MOUSE
Sequence: MLDIKAWAEYVVEWAAKDPYGFLTTVILALTPLFLASAVLSWKLAKMIEAREKEQKKKQKRQENIAKAKRLKKD
What are the official names of this protein?
Small integral membrane protein 15.
What is the protein family that this protein belongs to?
Belongs to the SMIM15 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LFTR_BRADU
Sequence: MTSRDSASSEITPAVLLRAYACGIFPMAESADDPTLFWVEPELRGVIPLGGFRVASRLARTVRSDGFRVTVNTAFKATIAGCAAPQAGREDTWINKRIRDLYSGLFELGHCHSVEAWQGDDLVGGLYGVSLGRAFFGESMFHTARDASKVALVHLVARLIHGGFELLDTQYVTEHLKNFGAVEIPRRRYTALLDKALAGEPGDFLKLSPGEAIPGARALEIIASRQ
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_ECOSM
Sequence: MANIKSAKKRAIQSEKARKHNASRRSMMRTFIKKVYAAIEAGDKAAAQKAFNEMQPIVDRQAAKGLIHKNKAARHKANLTAQINKLA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.