PharMolix/UniProtQA huggingface dataset:
Protein: PSBL_MAGST
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HXA1_HUMAN
Sequence: MDNARMNSFLEYPILSSGDSGTCSARAYPSDHRITTFQSCAVSANSCGGDDRFLVGRGVQIGSPHHHHHHHHHHPQPATYQTSGNLGVSYSHSSCGPSYGSQNFSAPYSPYALNQEADVSGGYPQCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGNDEKAEESSEKSSSSPCVPSPGSSTSDTLTTSH
What is the function of this protein?
Sequence-specific transcription factor (By similarity).  Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570).  Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Acts on the anterior body structures.  Seems to act in the maintenance and/or generation of hindbrain segments (By similarity).  Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).
What are the official names of this protein?
Homeobox protein Hox-A1, Homeobox protein Hox-1F.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Labial subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBM_DAUCA
Sequence: MEVNILAFIATALFILVPTAFLLIIYVKTETQNKNKKD
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RIMP_SYNJA
Sequence: MVHPLIPQLESLARPLAARLGYELVQMVFHTNQYPPVLRVDIRPLDPEQETSHADCEAMSQALEVELDRVDLIPGHYVLEVSSPGISNLLISDRDFVVFKGFAVEVTVDPPYKGKAVWSGHLLGRDEEKVALSLKGRRVQLPRASVQRVVLSGAETE
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_CHLAD
Sequence: MNEANSAMSDARRATIERTTGETSVTLTLTIDGSGRADIQTGIGFLDHMLTLWAKHGLFDLTVRAHGDLHVDEHHTAEDVCICLGRALDQALGTRAGIVRTAHSFVPMDEALALVAVDLGGRPYCVMQAEFATPRVGQLGTDLIGHLFESIAFNGRFNLHAQVLYGRNDHHKIEALFKACGRALDAATRYDPRLGGTIPSTKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBP2_RHIAP
Sequence: MKLLILSLALVLALSQVKGNQPDWADEAANGAHQDAWKSLKADVENVYYMVKATYKNDPVWGNDFTCVGVMANDVNEDEKSIQAEFLFMNNADTNMQFATEKVTAVKMYGYNRENAFRYETEDGQVFTDVIAYSDDNCDVIYVPGTDGNEEGYELWTTDYDNIPANCLNKFNEYAVGRETRDVFTSACLE
What is the function of this protein?
Salivary tick protein that acts by scavenging histamine at the wound site, outcompeting histamine receptors for histamine, thereby overcoming host inflammatory responses (PubMed:10360182).  Binds histamine with a high-affinity (Kd=1. 7 nM) (PubMed:10360182).  Contains two binding histamine sites (H and L), that appear to bind histamine with differing affinities (high and low) (PubMed:10360182).
What are the official names of this protein?
Female-specific histamine-binding protein 2, FS-HBP2, RaHBP2.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Histamine-binding salivary protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECF_CLOBL
Sequence: MYIKNVHLINFRNYDDMYLELSPNTNIFVGNNAQGKTNILESIYYSSIGKSHRTNKDKDLIKWDKNNTYLRTYVSRERLDKTIDINIFKNGKKAITVNKIKIKKISELMGNLNVVMFSPEDLRIIKDYPGNRRKFLDIELCKINNVYYHDLVQYNKILSERNTALKNWNNKINDIIDIYDEQLSKYGAFIIKERNKYLDKLNIIGKNIHKKITNDLEDINFRYLTNIKDFDNAEKELLIVLKKNRKKDLERNSTSIGPHRDDFEVSINNIDTRIFGSQGQQRTAVLTLKFASLEIIKNIIGEYPVLLLDDVLSELDSNRQKFVLNSIDKIQTIITCTGIEEIDKYLHKKQSQLYLVNNGKIKRV
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_METPP
Sequence: METRAIVRGVRLSVDKGRPVADLVRGKKVDQALNILEFTQKKAAVIIKKALESAIANAEHNDGADIDELKVKTIHVEQGATLKRFSARAKGRGNRISKPTCHIFVTVGN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RSMG_FERNB
Sequence: MEKTEIVRKYVEKLINSPINLTAYKDFDEAMAFLYLDSVLPVKSEDLGEFFLDIGTGGGVPGVFLSVEFDKKGLLVDSICKKVHFIQQTCKELGIKKVETLCARAEELKGKGDFFEKFDSAVSRAVSKIATVLELTAPYVKVGGKLLLYKGPGYNEELGQSVNAMKELGVKLSEVRRYSIRGKDRFLLVFEKISHTPDKYPRRIGIPEKRPIR
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM2_RHOCA
Sequence: MTLITPPFPTNRLRRMRRTEALRDLAQENRLSVKDLIWPIFITDVPGADVEISSMPGVVRRTMDGALKAAEGSRDAGHSRDLPVPLTDPAVKTETCEMAWQPDNFTNRVIAAMKQAVPEVAIMTDIALDPYNANGHDGLVRDGILLNDETTEALVKMALAQAAAGADILGPSDMMDGRVGAIRQAMEAAGHKDIAILSYAAKYASAFYGPFRDAVGASSALKGDKKTYQMNPANSAEALRNVARDIAEGADMVMVKPGMPYLDIVRQVKDAFGMPTYAYQVSGEYAMLMAAVQNGWLNHDKVMLESLMAFRRAGCDGVLTYFAPAAAKLIGA
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: MSRA_THET2
Sequence: MPEEIATLAGGCFWCTEAAFKLLRGVLEVVPGYAGGHVPHPTYEEVCTGTTGHREAVQVRFDPGVLPYADLLRYFFAVHDPTSEDRQGPDVGPQYSPAIFYHSEEQKRVAEAVMRELAPLYPKPIATKLLPFTTFYPAEAYHRDYFARHPEAPYCRLVIAPKLEKARKAFKSLLRP
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: RL17_GEOSL
Sequence: MRHNKAGRRLGRTTSHRIAMFRNMVTSLFAHERITTTDAKAKELRSIAEKMITLGKRGDLHAVRQAASYIRDKKVVTKLFSTIAPRYKERDGGYTRIIKLGIRPGDCAPLSVIELVEEQFEKKVKKSKPTAPAQAVATKPAVEETREAAAAQPQEPEVEISEVKDPAEECEAKAD
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PCKG_MYCSK
Sequence: MTSATIPGLDTAPTEHEGLLAWVREVAELTQPDRVVFTDGSEEECARLTEQLCEAGTFQKLNEEKKPNSYLALSDPSDVARVESRTYICSEREIDAGPTNNWMDPAEMRGIMTDLYRGSMRGRTMYVVPFCMGPLEAEDPKLGVEITDSEYVVVSMRTMTRMGQAALDKMGTDGFFVKALHSLGAPLEPGEKDVPWPCNDTKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYFIAAAFPSACGKTNLAMLQPTIPGWRAETVGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWSSNPNAMKTIEAGNTVFTNVAKTDDGDVWWEGLEGEPDHLIDWKGNDYILRETETKAAHPNSRYCTPISQCPTLAPEWDDPQGVPISAILFGGRRKTTVPLITQARDWQHGVFIGATLGSEQTAAAEGKVGTVRRDPMAMLPFLGYNVGDYFQHWIDIGKNADESKMPAVFFVNWFRRGDDGRFLWPGFGENSRVLKWAIERIEHKADGRSTPIGIVPTAQDLDLEGLDVDPEDVDAALAVKPEEWRQELPLIEEWFEFVGEKLPTGIRDEFDALKHRLAEEA
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLD_MICLT
Sequence: MHLKASEKRALGRTGLTVTALGLGTAPLGGLYAPVSRADADALLEAGWDSGIRYFDSAPMYGYGRCEHLLGDMLREKPERAVISTKVGRLMTNERAGRTLPPAPPKNPLDSGWHNGLNFREVFDYSYDGVMRSFDDSQQRLGFPEIDLLYVHDIGRVTHADRHEFHWNALTRGGGFRALTELRAAGNIKGFGLGVNEWQIIRDALEEADLDCSLLAGRYSLLDQVSEKEFLPLAQKRGMALVIAGVFNSGILAAPRGGEQKFDYADAPAEIIARTNRLHDICDEYHVPLAAAAMQFPLRHEAVSSILIGVRSPEQIRQNVVWFEQSIPDEFWTTLRSEGLIS
What are the official names of this protein?
Pyridoxal 4-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: THIE_LEUCK
Sequence: MIFDKTMLARYFIMGTQDVADEAEFLRILNQALRSGITLFQYREKGQGALVGQKKLQLAKQVRALTAQYHVPLVIDDDMALAHAIAADGIHFGQDDGRPVDNIKQSGNLFVGVSVSNQQEYQRIAHVAGIDHIGVGPIFATTSKSDAKPPIGISGLSQLIRIAHHPIVAIGGIQRDNLSKVLSTGVDGAAVISMISQSGDIQKTLADWRNRT
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: CUTC_ECO27
Sequence: MALLEICCYSMECALTAQQNGADRVELCAAPKEGGLTPSLGVLKSVRQRVTIPVHPIIRPRGGDFCYSDGEFAAILEDVRTVRELGFPGLVTGVLDVDGNVDMPRMEKIMAAAGPLAVTFHRAFDMCANPLNTLNNLTELGIARVLTSGQKSDALQGLSKIMELIAHRDAPIIMAGAGVRAENLHHFLDAGVLEVHSSAGAWQASPMRYRNQGLSMSSDAHADEYSRYVVDGAAVAEMKGIIERHQAK
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUT1_YEAST
Sequence: MAGSTSSLVICAIGIYATFLTWALVQEPLATRTWPNSMGKFQFPNVISLIQASVAMMMGYLYLNWKKVEYPPRKMIKDHWKQLMLISFTQSSSGPLATTSLKHVDYLTYMLAKSCKMIPVLLVHLLLYRTPIASQKKVVALLVSLGVTIFTIGGNDGKKLKRSFNESGNDNKLQGFGLLFSSLFLDGLTNATQDKLLKANKAKEKGKQTLITGAHLMFTLNLFVILWNILYFIVIDCKQWDNAVSVLTMDPQVWGYLMLYSFCGAMGQCFIFYTLEQFGSLVLIMITVTRKMVSMILSIIVFGKSVRFQQWVGMFIVFGGITWEALNKKKANIPKAKSA
What is the function of this protein?
May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen.  Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum.  Overexpression confers resistance to the immunosuppressive drug, leflunomide.
What are the official names of this protein?
UDP-galactose transporter homolog 1, Multicopy suppressor of leflunomide-sensitivity protein 6.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YEBY_SHIFL
Sequence: MMKKSILAFLLLTSSAAALAAPQVITVSRFEVGKDKWAFNREEVMLTCRPGNALYVINPSTLVQYPLNDIAQKEVASGKTNAQPISVIQIDDPNNPGEKMSLAPFIERAEKLC
What are the official names of this protein?
Uncharacterized protein YebY.
Protein: RS6_PROM4
Sequence: MTNQPYYETMYILRPTIPEDEVDSHLKKYTEILESAGGEVLDSQMRGKRRLAYPIGKHKEGIYVQLSHQGDGQHIAVLEKAMRLTEDVIRYLTVKQDGPLPAKRVVKTSEKNVKEDKEVENKETTTEDKDQKGDLKETKKSENKDSVTEAEGQKDIKEAKEIENKEIEKKED
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PYRR_MYCPA
Sequence: MGAAGNTGSSGDSRELMSAADVGRTISRIAHQIIEKTALDGPDGPRVVLLGIPTRGVTLADRLARNIGEYSGVEVGHGALDITLYRDDLMQKPPRPLEATSIPAGGIDDALVILVDDVLYSGRSVRSALDALRDVGRPRVVQLAVLVDRGHRELPLRADYVGKNVPTSRSESVHVLLAEHDGADGVVISR
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: Y1664_PSEA7
Sequence: MLIPHDLLEADTLNNLLEDFVTREGTDNGDETPLDVRVERARHALRRGEAVILFDPESQQCQLMLRSEVPAELLRD
What are the official names of this protein?
UPF0270 protein PSPA7_1664.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: BETI_ECO8A
Sequence: MPKLGMQSIRRRQLIDATLEAINEVGMHDATIAQIARRAGVSTGIISHYFRDKNGLLEATMRDITSQLRDAVLNRLHALPQGSAEQRLQAIVGGNFDETQVSSAAMKAWLAFWASSMHQPMLYRLQQVSSRRLLSNLVSEFRRELPREQAQEAGYGLAALIDGLWLRAALSGKPLDKPLAHSLTRHFITQHLPTD
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: RADA_HAEIN
Sequence: MAKAPKTAYVCNDCGAEFSRWQGQCSACKAWNTITEVRLISTAKSKNDRFSGYAGETQAKIQTLSEISLQETPRFSSGFSELDRVLGGGIVPGSAILIGGHPGAGKSTLLLQVMCGLAKNMTALYVTGEESLQQVAMRASRLGLPSDQLKMLSETSVEQICNLADQLKPQIIVVDSIQVMHLADIQSSPGSVAQVRECASFLTRYAKTRQVAIIMVGHVTKDGTLAGPKVLEHAIDCSLLLEGEADSRYRTLRSHKNRFGAVNELGVFGMTEQGLREVKNPSAIFLSRGDEITSGSSVMVLWEGTRPLLVEIQALVDHSMLANPRRVAVGLEQNRLALLLAVLHRHGGLQMADQDVFVNVVGGVKVSETSADLALLLALISSFRNRPLPQDLVIFGEVGLAGEIRPVPSGQERISEAAKHGFKRAIVPFGNKPKSAVENMQVFTVKKLTDALAVLDNL
What is the function of this protein?
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks.  Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster.  Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB.  Does not have RecA's homology-searching function.
What are the official names of this protein?
DNA repair protein RadA, Branch migration protein RadA.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RadA subfamily.
Protein: CTBP2_BOVIN
Sequence: MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVLFYDPYLQDGTERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTTAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ
What is the function of this protein?
Corepressor targeting diverse transcription regulators.  Functions in brown adipose tissue (BAT) differentiation (By similarity).  Isoform 2 probably acts as a scaffold for specialized synapses.
What are the official names of this protein?
C-terminal-binding protein 2, CtBP2.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
What are the subcellular locations of this protein?
Nucleus. Synapse.
Protein: DCD_FRATF
Sequence: MTIKSDKWIKKMSQEHNMIEPFEAGQVKVINNQKIVSYGTSSYGYDVRCADEFKIFTNINSSIVDPKNFNDKNFVDFKGDVCIIPPNSFALARTVEKFKIPRDTLVVCLGKSTYARCGIIVNVTPLEPEWEGYVTLEFSNTTPLPAKIYANEGVAQMLFFQSDEECETSYADKGGKYQGQVGVTLPKC
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: ACER1_MOUSE
Sequence: MHVPGTRAKMSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFYGVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILWLLASGYSVWLPRCYFPKFVKGNRFYFSCLVTITTIISTFLTFVKPTVNAYALNSIAIHILYIVRTEYKKIRDDDLRHLIAVSVVLWAAALTSWISDRVLCSFWQRIHFYYLHSIWHVLISITFPYGIVTMALVDAKYEMPDKTLKVHYWPRDSWVIGLPYVEIQENDKNC
What is the function of this protein?
Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:12783875).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875).  Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:12783875).  May also hydrolyze dihydroceramides to produce dihydrosphingosine (By similarity).  ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:27126290, PubMed:29056331).
What are the official names of this protein?
Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, maCER1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3.
What is the protein family that this protein belongs to?
Belongs to the alkaline ceramidase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RHAD_ECO57
Sequence: MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIALYHDNFHPQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGVVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAEVLVKVYSMGGMKQTISREELIALGQRFGVTPLASALAL
What is the function of this protein?
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
What are the official names of this protein?
Rhamnulose-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. RhaD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPB9_MOUSE
Sequence: MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB9, RNA polymerase II subunit B9, DNA-directed RNA polymerase II subunit I, RNA polymerase II 14.5 kDa subunit, RPB14.5.
What is the protein family that this protein belongs to?
Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Protein: HFC1A_ORYSJ
Sequence: MDGLHTELALGLIGCCGGDGQQQTAPFVAKTYQMVCDPRTDALVRWGRDNNSFVVVDPAAFSQLLLPCFFKHGNFSSFVRQLNTYGFRKVHPDRWEFAHESFLRGQTHLLPRIVRRKKRGEGGGGGGGASCSFGGGAGEHQVAAAAASVGMSGEEEDAAEDVLAKEAALFEEVQRLRHEQTAIGEELARMSQRLQATERRPDQLMSFLAKLADDPNAVTGHLLEQAAERKRRRQHLPSHEPTVCPLPPAPPPQPPQPLLALAGAAAMDGTYWWTTEHHHHHHHQMKPMTVLPSLEPPTASCGVHQVPELGGGGVMGLTTDGEAKVEPPFPFCLLGQAFF
What is the function of this protein?
Transcriptional regulator that specifically binds DNA of heat shock promoter elements (HSE).
What are the official names of this protein?
Heat stress transcription factor C-1a, Heat stress transcription factor 13, rHsf13, Heat stress transcription factor 2, OsHsf-02.
What is the protein family that this protein belongs to?
Belongs to the HSF family. Class C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIAB_PSEA6
Sequence: MTKKLFIKTWGCQMNEYDSQKMADLLDSTHGYQVADTAEEADIILLNTCSIREKAQEKVFHQLGRWKNLKQDKPELIIGVGGCVASQEGQVIRQRAPFVDLVFGPQTLHRLPEMINQIKGGSSSVIDISFPEIEKFDRLPEPKAEGPTAFVSIMEGCSKYCTFCVVPYTRGEEVSRPVDDVLLEVAQLAEQGVREVNLLGQNVNAFRGPHHDGAICTFAELLEMVASIDGIDRIRYTTSHPVEFTDDIIDAYATIPELVDHLHLPVQSGSDRVLNLMKRGHTAIEYKSKIRKLRKIRPNLSMSSDFIIGFPGETDDDFEATMDLIQAMDFDLSFSFIYSARPGTPAADLPDDVSETTKKERLQLLQNRITQQALRIARNMIDSEQRVLVEGPSKKNPMELSGRTENNRVVNFEGTPDMIGGFVDVKITDVFANSLRGDVLRKEADMNLRINVAPQAILAKQTNKTDALGVAQFVPAH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHEB_NEOHI
Sequence: MLDAFSRVVVNSDAKAAYVGGSDLQALKKFIADGNKRLDSVNAIVSNASCIVSDAVSGMICENPGLIAPGGNCYTNRRMAACLRDGEIILRYVSYALLAGDPSVLEDRCLNGLKETYIALGVPTNSSVRAVSIMKAAAVAFITNTASQRKMATADGDCSALASEVASYCDRVAAAIS
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex.
What are the official names of this protein?
R-phycoerythrin beta chain.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=Forms the periphery of the phycobilisome rod.