PharMolix/UniProtQA huggingface dataset:
Protein: OSP1B_ORPS1
Sequence: ECLGWMKGCEPKNNKCCSSYVCTYKYPWCRYDL
What is the function of this protein?
Voltage-gated sodium channel Nav1. 7/SCN9A inhibitor.
What are the official names of this protein?
Mu-theraphotoxin-Osp1b, Mu-TRTX-Osp1b.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 22 (Htx-4) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL16_MESHJ
Sequence: MLQPKKTKHRKTFRLYHDKRDAHSGNFVAFGDYGLQATGSAWVSAAQIEAARIAITRRMGREGQVIIRVFPHLALTSKPIGVRMGSGKGSVDRWVAVVKRNTILFEVRGVKDEIARDALRLGGHKLPLKWKIVATV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: Y521_ARCFU
Sequence: MEIRRADKDDLDDFVRVYVESYRGLEDYAYTRKRDVKNYFKWLLSRDKDGVMVAEIDGEAVGFVACDTNWFSIFERKKVGEIHELFVLPEFRGEGIGAKLMEKALEYALERNRKVAELWVGRTNYRARRFYASQDLRRPESGGSGSE
What are the official names of this protein?
Uncharacterized N-acetyltransferase AF_0521.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: Y1072_RUEPO
Sequence: MAGHSKWANIQHRKGRQDAARSKLFSKFSKEITVAAKMGDPDPDKNPRLRLAIKEAKSQSMPKDNIERAIKKAIGGDGDAYEEIRYEGYGPNGVAVIVEAMTDNRNRTASNVRSTFTKHGGNLGETGSVGFMFERKGEVVYPASVGDADTVMMAAIEAGAEDVESSEEGHVIWCADTDLNEVSTALEAELGESDSTKLVWKPSTTTELDLEAMQKLMKLVDALEDDDDVQRVTTNFEASDEVMAAL
What are the official names of this protein?
Probable transcriptional regulatory protein SPO1072.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_MYCA9
Sequence: MPELPEVEVVRRGLHHHLVGKTIASTLVYHERAVRRQSGGAVELAGLLAGQQISGTGRRGKYLWLTLEGSSGAQALVVHLGMSGQMLIGPISRPQHLRIAATLDDGSVLSFVDQRTFGGWMVTDLVTVDGSELPEPVAHIARDPLDELFEIGAVVTRLRGKHTEIKRALLDQTVVSGVGNIYADEALWQARVHGRRLTDGMSRAKLTEVLDSAAAVMRLALAQGGTSFDDLYVNVNGESGYFDRSLEAYGREGEPCRRCGRAMRREAFMNRSSYFCPSCQRLVEPR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: NADK_SALSV
Sequence: MNNHFKCIGIVGHPRHPTALTTHEMLYRWLCDQGYEVIVEQQIAHELQLKNVPTGTLAEIGQQADLAVVVGGDGNMLGAARTLARYDINVIGINRGNLGFLTDLDPDNALQQLSDVLEGRYISEKRFLLEAQVCQQDRQKRISTAINEVVLHPGKVAHMIEFEVYIDETFGFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITLVPMFPHTLSARPLVINSSSTIRLRFSHRRSDLEISCDSQIALPIQEGEDVLIRRCDYHLNLIHPKDYSYFNTLSTKLGWSKKLF
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XERC_ECOLI
Sequence: MTDLHTDVERYLRYLSVERQLSPITLLNYQRQLEAIINFASENGLQSWQQCDVTMVRNFAVRSRRKGLGAASLALRLSALRSFFDWLVSQNELKANPAKGVSAPKAPRHLPKNIDVDDMNRLLDIDINDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLESGEVWVMGKGSKERRLPIGRNAVAWIEHWLDLRDLFGSEDDALFLSKLGKRISARNVQKRFAEWGIKQGLNNHVHPHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates.  The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or psi) sites.  In the complex XerC specifically exchanges the top DNA strands (By similarity).
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with DNA.
Protein: THIO_CLOSG
Sequence: MLVLDKKTFEEEVLKTKGYVLVDYFGDGCVPCEALMPDVE
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: MGSA_PSET1
Sequence: MDQKIQSLPAKKNIALVAHDGKKAALKLWCIKHLNALSEHTLYATGTTGHLINKTTGLDVIQLLSGPMGGDQQLGAKIAEHEIHMLVFFWDPLASQPHDPDVKALLRLAAVWNIPVACNEVSADMLLSSPLMNVELERTLPDYEKYLATRQIDI
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: GGGPS_HALSA
Sequence: MTAPWADWDHVLKIDPDKSLVDGETFDDIAQTGTDAIEIGGTLDVTTEKMRRVIDACRTHEVPLYQEPSNPAVVVEDEALDGYLVPVVLNAGDPFWITGAHKEWVRIADLDWERTTTEAYIVMNPDASVAEYTGADCGLDADEVGAYATVAERLLGQEVVYVEYSGTLGDPAVVEAAAGGVDDAAVFYGGGIDGYDAAYRMGAHADTIVVGDLVHEAGVDAVRETVSGVRDAQAEE
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_ALISL
Sequence: MSKEFSRAQRVSQQLQKELAVILQREVRDSRIGMVTISDVEVSRDLAYAKVFVTFFCVGEQTPETCLAALKEHEVPVRMMLGKRIRHRLTPEVRFTYDNTLVEGMRMSNLVSDVVNTDKRKMAESGRTESDEGEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGG9_YEAST
Sequence: MTLALVFVSNESNFTVNTVFASGLASSSAPLPASPVELGTLPAPAPAAPAMNPPIGMEISGMFNTVFSSLIKLEVSKRVNCEMSCTILEILGSTGLTSSLCDGAVVVVELKRVVIVIGEISAGVTRVFIQIEEDLFASIRKDILGAYLIDCVCC
What are the official names of this protein?
Putative uncharacterized protein YGL069C.
Protein: TIP51_ARATH
Sequence: MRRMIPTSFSSKFQGVLSMNALRCYVSEFISTFFFVLAAVGSVMSSRKLMAGDVSGPFGVLIPAIANALALSSSVYISWNVSGGHVNPAVTFAMAVAGRISVPTAMFYWTSQMIASVMACLVLKVTVMEQHVPIYKIAGEMTGFGASVLEGVLAFVLVYTVFTASDPRRGLPLAVGPIFIGFVAGANVLAAGPFSGGSMNPACAFGSAMVYGSFKNQAVYWVGPLLGGATAALVYDNVVVPVEDDRGSSTGDAIGV
What is the function of this protein?
Potential aquaporin, which may facilitate the transport of water and small neutral solutes across cell membranes.
What are the official names of this protein?
Probable aquaporin TIP5-1, Tonoplast intrinsic protein 5-1, AtTIP5;1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. TIP (TC 1.A.8.10) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RN152_RAT
Sequence: METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGITKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERTLLPGDMGCRLLPGSQQKSLTVVTIPAEQQPLQGGAPQEAVEEEPDRRGVAKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG
What is the function of this protein?
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation.  Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability.  Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.  Induces apoptosis when overexpressed.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF152, RING finger protein 152, RING-type E3 ubiquitin transferase RNF152.
What is the protein family that this protein belongs to?
Belongs to the RNF152 family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass membrane protein.
Protein: MDCC_PSEF5
Sequence: METLSFEFPAGQPGRGRALVGCVGSGDLEVLLEPGQPGKLSIQVQTSVNGSASRWQHLFERLFDGQTPPALLIDIHDFGATPGVVRLRLEQGFEEIGHD
What is the function of this protein?
Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.
What are the official names of this protein?
Malonate decarboxylase acyl carrier protein, Malonate decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the MdcC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 2AAA_PEA
Sequence: VEAAHLKTDIMSVFDDLTQDDQDSFRFLAVEGCAALGKLLEPQDCLAHILPVIVNFSQDKSWRVRYMVANQLYELCEAVGPDSTKTELVPAYVRLLRDNVAEVRIAAAGKVSKFSRILSPELAIQHILPCVKELSTDSSQHVRSALASVIMGMAPVLGKDATIEQLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDDKLGALIMQWLKDKEYSIRNAAANNVKRLAAEEFGPEWAMQHIIPQVLDMINDPHYLYRMTILHAISLLAPVLGSEITSTNLLPLVVNASKDRVPNIKFNVAKVLQSLIPIVDESVVESTIRPCLVELSEDPDVDVRFFASQALQSSDQVKMSS
What is the function of this protein?
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
What are the official names of this protein?
Protein phosphatase PP2A regulatory subunit A, PR65.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit A family.
Protein: MQO_BACC3
Sequence: MSNMQQKTDVILIGAGIMSATLGSLLKELAPEWEIKVFEKLASAGEESSNEWNNAGTGHSALCELNYTSEKSDGSIDISKAVKVNEQFQLSRQFWAYLVKSKLIRNPQDFIMPLPHMSLVQGEKNVEFLKNRFEALSKNPLFQGMEFSDAPETLKKWLPLIMEGRTSNEPMAATKIDSGTDVNFGALTRMLFDYLKTKDVELNYKHSVENIKRTKNGLWEVKVHDMNSGKIEHHTAKFVFIGGGGGSLPLLQKTGIPESKHIGGFPVSGLFMVCKNQKVVEQHHAKVYGKAKVGAPPMSVPHLDTRYIDNKKALLFGPFAGFSPKFLKTGSNLDLIGSVKPNNVLTMLAAGVKEMGLTKYLIQQVMLSHEKRMEELREFIPNAKSEDWDIVVAGQRVQVIKDTDAGGKGTLQFGTEVVSAADGSIAALLGASPGASTAVHVMLEVLEKCFPSRMVEWEGKIKEMIPSYGISLTENPRLFQDLHTSTGRTLGLNEKETVHN
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: TRI16_FUSSP
Sequence: MALSRCLRTRTAFLSPLDQLNSSFYIRWSLVLHAKDRDKAVNRLSKGLNAVTSKLPFLKGRINYHTDTANNKIASASRAVISMSDDSPNLSLRELRPAKELPSLARIKQQGAPSHLFTDDLYSLPIFIDTTSKQSHPVLKTTYAPIEGGLILNICVHHGVMDGQGLATLTDLWASFTRQQDQNENEVQQPKNLPDPDEPLTRTARLATAINATADPEITDIETSLQRYRNDRILEQNIAASTGDSRKKTSRIFAFSSNKLKDAKEVLANNGCHVTTNSILNAAVWSNLTRVRLSRRTQLPPTPFARFTQMVDGRRQLLPKINKPGPYMGNVVLTSSADVSLDTLVATGFFNYLSVSLMAPVAQAIYDASRKVTTEYIDGFLKTLQKVDDPASLGIGSMSQHGVDFISTSVANAPFYECDFGPSLSEDSAGGKEGKPVFVRYPYIDWADGNMILLPRRRQPTENDETIEAYIMLAEDDLVALAEDPGFCSWLKE
What is the function of this protein?
Trichothecene 8-O-acetyltransferase; part of 2-gene cluster involved in trichothecene C-8 modification that mediates the biosynthesis of T2-toxin (PubMed:14532047, PubMed:14690377).  The biosynthesis of trichothecenes begins with the cyclization of farnesyl diphosphate to trichodiene and is catalyzed by the trichodiene synthase TRI5 (PubMed:3800398).  Trichodiene undergoes a series of oxygenations catalyzed by the cytochrome P450 monooxygenase TRI4 (PubMed:7651333).  TRI4 controls the addition of four oxygens at C-2, C-3, C-11, and the C-12, C-13-epoxide to form the intermediate isotrichotriol (PubMed:16917519).  Isotrichotriol then undergoes a non-enzymatic isomerization and cyclization to form isotrichodermol (PubMed:2317042).  During this process, the oxygen at the C-2 position becomes the pyran ring oxygen and the hydroxyl group at C-11 is lost (PubMed:2317042).  More complex type A trichothecenes are built by modifying isotrichodermol through a series of paired hydroxylation and acetylation or acylation steps (PubMed:11352533).  Isotrichodermol is converted to isotrichodermin by the acetyltransferase TRI101 (PubMed:10583973).  TRI101 encodes a C-3 transacetylase that acts as a self-protection or resistance factor during biosynthesis and that the presence of a free C-3 hydroxyl group is a key component of Fusarium trichothecene phytotoxicity (PubMed:10583973).  A second hydroxyl group is added to C-15 by the trichothecene C-15 hydroxylase TRI11, producing 15-decalonectrin, which is then acetylated by TRI3, producing calonectrin (PubMed:9435078, PubMed:8593041).  A third hydroxyl group is added at C-4 by the cytochrome P450 monooxygenase TRI13, converting calonectrin to 3,15-diacetoxyspirpenol, which is subsequently acetylated bythe acetyltransferase TRI7 (PubMed:12135578, PubMed:11352533).  A fourth hydroxyl group is added to C-8 by the cytochrome P450 monooxygenase TRI1, followed by the addition of an isovaleryl moiety by TRI16 (PubMed:12620849, PubMed:14532047).  Finally, the acetyl group is removed from the C-3 position by the trichothecene C-3 esterase TRI8 to produce T-2 toxin (PubMed:12039755).
What are the official names of this protein?
Trichothecene 8-O-acetyltransferase, Trichothecene biosynhesis protein 16.
Protein: MOAC_SYNWW
Sequence: MNFTHINEQGYARMVDVSSKNDSERIAIAQAIVKMQPETMGKIRDGAIKKGDVLGVAQIAGIMGAKQTSALIPMCHPLNLTSVNLEFAFDEVNASIIIEAEVKTTGKTGVEMEAITAVSVAALTIYDMSKAVDRWMEITDIKLLEKSGGKSGHLVRD
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: Y457_MYCPN
Sequence: MWITTTPWSKHSPNWVLADNGEKLIVPEIILGDAQGPTRNEWYIGLSSVLGFSFWSPDYDGVGTWLDAATQLNEQGGGDVITYSSGAHIVRTLLLAASQSNVHSTFTSKALGNDQTSSMTSSTTAVTVAKSGDGQQQTGEQKEEDWKDISKADLFKDDPYVLKNFGDSTTQAKMQSGGSTNSNGNGSQASLAFTKKALSLLKFLVDNKILKKDKVKEAIMNPDQYLSKRSKLDSNNQKPTKDDFIGSEFKDLYENAAKLNRFNSIWAEKDTDNAKFLITVVDSYFPVLPVPAAGLNETSPTLLKPWFQFRSAPSGNGTIRDYGFIPENK
What are the official names of this protein?
Uncharacterized protein MPN_457.
What is the protein family that this protein belongs to?
To the C-terminal of MG321/MPN_456.
Protein: RNZ_BACCN
Sequence: MEFVFLGTGAGVPSKGRNVSAIALQLLEERGGTWLFDCGEATQHQILHTSVRPRRIEKIFITHLHGDHIFGLPGLLGSRSFQGGTTPLTVYGPKGIEQFIEVALSVSTTHVKYPLEIVEITEEGIVFEDKQFYVETKRLSHGIECFGYRIVEKDIQGPLLVEKLREANVKPGPIFKRLKDGEIVELEDGRVLDGKDFIGPPQKGRIITILGDTRYCDASRILAQDADVLVHEATFAAADQTQAHDYFHSTTEQAARIALEANVKRLILTHISSRYQGDMYKELLREAKAVFAHTEIAMDLKSFPVER
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: GYRB_STRR6
Sequence: MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLHHLVWEIVDNSIDEALAGFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVADLEIVGDTDKTGTTVHFTPDPKIFTETTIFDFDKLNKRIQELAFLNRGLQISITDKRQGLEQTKHYHYEGGIASYVEYINENKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVMSFANNIHTHEGGTHEQGFRTALTRVINDYARKNKLLKDNEDNLTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFSDFLMENPQIAKRIVEKGILAAKARVAAKRAREVTRKKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPIYGVKVGSEIKEYIQPGADQEIKLQEALARYSEGRTKPTIQRYKGLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYSTLDV
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPRE_XENLA
Sequence: MTAARAGALGSVLCVLTGASRGFGRTLAHELCPRVLPGSTLLLVSRTEEALKGLAEELGHEFPGVRVRWAAADLSTTEGVSATVRAARELQAGTAHRLLIINNAGSIGDVSKMFVDFSAPEEVTEYMKFNVSSPLCLTASLLKTFPRRPDLQRLVVNVSSLAALQPYKSWVLYCSGKAARDMMFRVLAEEEDDVRVLSYAPGPLDTDMHEVACTQTADPELRRAIMDRKEKGNMVDIRVSANKMLDLLEADAYKSGDHIDFYD
What is the function of this protein?
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
What are the official names of this protein?
Sepiapterin reductase, SPR.
What is the protein family that this protein belongs to?
Belongs to the sepiapterin reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VNS1_BTV17
Sequence: MERFLRKYNISGDYANATRTFLAISPQWTCSHLKRNCLFNGMCVKQHFERAMIAATDAEEPAKAYKLVELAKEAMYDRETVWLQCFKSFSQPYEEDVEGKMKRCGAQLLEDYRKSGMMNEAVKQSALVNSERIRLDDSLSAMPYIYVPINDGQIVNPTFISRYRQIAYYFYNPDAADDWIDPNLFGIRGQHNQIKREVERQINTCPYTGYRGRVFQVMFLPIQLINFLRMDDFAKHFNRYASMAIQQYLRVGYAEEIRYVQQLFGRVPTGEFPLHQMMLMRRDLPTRDRSIVEARVRRSGDENWQSWLLPMIIIREGLDHQDRWEWFIDYMDRKHTCQLCYLKHSKQIPACSVIDVRASELTGCSPFKMVKIEEHVGNDSVFKTKLVRDEQIGRIGDHYYTTNCYTGAEALITTAIHIHRWIRGSGIWNDEGWQEGIFMLGRVLLRWELTKAQRSALLRLFCFVCYGYAPRADGTIPDWNNLGNFLDIILKGPELSEDEDERAYATMFEMVRCIITLCYAEKVHFAGFAAPACEGGEVINLAARMSQMWMEY
What are the official names of this protein?
Non-structural protein NS1.
What is the protein family that this protein belongs to?
Belongs to the orbivirus non-structural protein NS1 family.
Protein: EFTU_POLAQ
Sequence: MAKEKFERTKPHVNVGTIGHVDHGKTTLTAAIATVLSKAFGGEAKAYDQIDAAPEEKARGITINTAHVEYETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLARQVGVPYIVVFLNKCDMVDDAELLELVEMEVRELLSKYDFPGDDTPIIQGSAKLALEGDEGPMGKEAIMKLAEALDTYIPTPERAIDGAFLMPVEDVFSISGRGTVVTGRIERGIVKVGEEIEIIGIKPTLKTTCTGVEMFRKLLDQGQAGDNVGILLRGTKREEVERGQVLAKPGSITPHTHFTAEVYILGKDEGGRHTPFFNNYRPQFYFRTTDVTGSIELPKDKEMVMPGDNVTITVKLIAPIAMEEGLRFAIREGGRTVGAGVVAKILA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACH10_RAT
Sequence: MGTRSHYLDLGFLLLLFLPAECLGAEGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRGTSASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLILAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLCVRERGEPCGQSKPLESAPSLQPPPASPAGPCHEPRCLCHQEALLHHIASIASTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLIVLVQAL
What is the function of this protein?
Ionotropic receptor with a probable role in the modulation of auditory stimuli.  Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane.  In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing.  This may protect against acoustic trauma.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha-10, NACHR alpha-10.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: COXX_CORJK
Sequence: MKTFAETAKAYLALTKPRVIELLLVATIPAMLQAARGEVNFGLILLTLIGGWMGAGAANTFNNVVDHDIDQLMRRTRRRPTARQTVSVGEARVFAWVLLIASVLWLGFLCHSWLAAGFIVLTNWFYVFVYTKWLKRRTWQNVIWGGAAGCMPVIVGWAVITDNNGGAFHAGWSSWLQAIILFMIIFFWTPPHTWALGMRYREDYEAAGVPMMPVVKPPLQVTRQILAYTWAAVITSLLLVPAASWIYLAAALISGGWFIIKAHMLHQGVKNGTPVKPMQLFFLSNNYLSILFVALSVDAVLGWQTLAHAVLG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.