PharMolix/UniProtQA huggingface dataset:
Protein: EI2BB_RABIT
Sequence: MPGATEKGSELSERIESFVEALKRGGGQRSSEDMARETLGLLRRIITDHRWSNAGELMELIRREGRRMMAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLSEDFSFHYAQLQSNIVEAINELLVELEGTTENIAAQALEHIHSNEVIMTIGLSRTVEAFLREAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILDKVGCHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPEDHVL
What is the function of this protein?
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
What are the official names of this protein?
Translation initiation factor eIF-2B subunit beta, eIF-2B GDP-GTP exchange factor subunit beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family.
Protein: RL10_IDILO
Sequence: MAIGLAGKKAIVKEVNDVASNALAVTVAEYRGIEVADMTALRKKAREQGIFVKVVRNTLAKRAFEGTQFDDMGDALKGPLVYGFSMDAPGASARLFKDFSKENKNLQVTALSIGNGIMGPEKLDAVASLPTRDEALAKLLATFKEPVSKFVKTVNEVPSKFVRTLAAIKDAK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: BBP_CRYNJ
Sequence: MWRPAAKTTGTNDVPLANKRRFGLPEEGPPSNSPSYAPRPAADIQYFNGRQERERDARDDRERPRDDYDRRRDDYVRDDRDRRYDDYPRDGHSDRRDERSKWDEGDRREAPRGRERSRDRGDSNEDGPRKRRSRWGDASAKVNVPGMPVAVMGNVSQTELDNYAIHVRLEEINRKLRTGDVVPPEGQRSPSPTPQYDAYGRRTNTRELRYRKKLEDERTRLIDRAVKSDPNFRPPVDFQHKRGSRPQDKVYIPVKEFPEINFFGLLVGPRGNSLKKMERESGAKISIRGKGSVKEGKGRAGNFPQDEEDELHCLITADDESKVKTCVALINKVIETAASTPEGENDHKRNQLRELASLNGTLRDDENQLCQNCGEKGHRRWECPQQRVYSANVICRICGGAGHMARDCRGRGDPSLTQNKQTAFDSEYTALMAELGEGGGSTPGSAPAAAIGAPGAIPPQSRVPPWRLPENWQTNSGGFRGPPNFQAQGYQQAAPGAAAYGQQAYPGYAGYQTGAVSGYGSPATGGADAYAAYYASMGQQAPAAAV
What is the function of this protein?
Necessary for the splicing of pre-mRNA.  Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity).
What are the official names of this protein?
Branchpoint-bridging protein.
What is the protein family that this protein belongs to?
Belongs to the BBP/SF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FCSD2_MOUSE
Sequence: MQPPPRKVKVTQELRNIQGEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGIQKLASQYLKRDWPGIKTDDRNDYRSMYPVWKSFLEGTMQVAQSRINICENYKNFISEPARAVRSLKEQQLKRCVDQLTKIQTELQETVKDLVKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNTKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAIQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNELECHGVALSEQSRAELEQKIDEARESIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADAEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFSGRIGVFPSVLVEELSASENGDTPWTREIQISPSPKPHTSLPPLPLYDQPPSSPYPSPDKRSSQFFPRSPSANENSLHAESPGFSQASRQTPDTSYGKLRPVRAAPPPPTQNHRRTTEKMEDVEITLV
What is the function of this protein?
Adapter protein that plays a role in endocytosis via clathrin-coated pits.  Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor.  Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling.  Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits.  Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (By similarity).  When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex (PubMed:23437151).  Does not promote actin polymerisation in the absence of membranes (By similarity).
What are the official names of this protein?
F-BAR and double SH3 domains protein 2, Protein nervous wreck 1, NWK1, SH3 multiple domains protein 3.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium. Note=Partially localized at clathrin- coated pits at the cell membrane. Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits. Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions.
Protein: THIC_BACTN
Sequence: MEQKIKFPRSQKVYLPGKLYPNIRVAMRKVEQVPSVSFEGEEKIATPNPEVYVYDTSGPFSDPSMSIDLKKGLPRLREEWIVGRGDVEQLPEITSEYGQMRRDDKSLDHLRFEHIALPYRAKKGEAITQMAYAKRGIITPEMEYVAIRENMNCEELGIETHITPEFVRKEIAEGHAVLPANINHPEAEPMIIGRNFLVKINTNIGNSATTSSIDEEVEKALWSCKWGGDTLMDLSTGENIHETREWIIRNCPVPVGTVPIYQALEKVNGVVEDLNWEIYRDTLIEQCEQGVDYFTIHAGIRRHNVHLADKRLCGIVSRGGSIMSKWCLVHDQESFLYEHFDDICDILAQYDVAVSLGDGLRPGSIHDANDEAQFAELDTMGELVLRAWEKNVQAFIEGPGHVPMHKIKENMERQIEKCHDAPFYTLGPLVTDIAPGYDHITSAIGAAQIGWLGTAMLCYVTPKEHLALPDKEDVRVGVITYKIAAHAADLAKGHPGAQVRDNALSKARYEFRWKDQFDLSLDPERAQGYFRAGHHIDGEYCTMCGPNFCAMRLSRDLKKNAKSDK
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: WDY_DROPS
Sequence: MIFNASQDSKTEIEYQTISSTQTYLAEEQSERLHNLISKEQLEKLNQAFNERPDSQVGFDDLRGLLLEQDITFNDAVYNRLFLKINQNRDFMVDWNEFVSYLIFGFQEEDPSSQKESLILPISVAPSVRKTEHRSTVCCVALLKAKSDQVPIEEVTETVNFSFGGEDSPEASGMWVTASHEGMLRFWTSHMEPIRTATSESSKPHAVYCMSYAFYNNGKVHSKLVLGDYAGNVRILSYSPNLRGPFQAKPGAALIEVVWADVLKGKIPQMIPKEYINLHNEMISCVHYSLHMNALFATAEYRNTKKYRGRCPGMIMVTYDERSNFRVPLGVSTFFVAESHNIVVTGGPDTFVRIWDVYIPTEPSAILTGHNGGIVMVFVQPEENKVYSVDYQKIIKVWDLQEHTLLQTYGELVRLIHPSETDMTYFYHSHLRELIVAGRKLISIKCCPRVRVDLTDGNTHAAPVSVVLYNRLFRNIVTCGLDSYIIVWDPWSGRRKIIMKNCHTKMIYGEIIDIEITAATFDPLEQFLLTGARDGTLKIWNYNNAVVVRNMSIMPDQEVTSVIWVVDRILAMGWDRQVTEFNDVEGREYGDPKKWSKFHTDDITCADVKLGEGVVTATYSGEVIFWKLETGQPYRRYSVMDPTRFIELKLTPEEEKLMRRSKRLMSRLGSSRMSRATAITMPKADDGRDYGQNVPISVQAVLFLQTRPQTIQHGSVFISLDTGYIQKVYSHHSRGGYMSQFLSVHKTGDCVLTMCTDRKNRYIYTGTAFGYIKVWHIVNYPEAEKVHVCMPRLRLEFIFMRKEFWVTRAKRVVRHQREPLLVSSYKAHLKAINSIAFINLPKIVFRGSHDYSCRLWTQGGRYLGTLGTVLPWSKLSPFERAGSENQVYRLPPDIKKVASSTTLKVISGVQMDRPAKRAEVKAPEDRDEETAQTDDGYDLKKIFDKPLKEPILGKHFTLPGKSVMDQRIDVDTTQSYIAVYTHLKVHHTEMLERLPTPAVISRVAGENYMDHYVPVEGKVDLSGSALNIKQPPRRNVRPNDPRNMRMAKTRGDMGPGPSPSQQSE
What are the official names of this protein?
WD repeat-containing protein on Y chromosome, WD40 Y.
Protein: RSMH_RIPO1
Sequence: MTNSCDRPLITPLEPPNASFIHISVLSQETIAGLNIIPGGHYLDATVGSGGHSRLILATFPDVRITAIDRDSQAIAAAASNLAELGSERLKFWQGNFADYPGKIAEFSGIIADLGVSSPQFDFPERGFSFRHEGALDMRMDQTQSLTAGEIINQWSETALADLFYQYGEERRSRSMAKHIVQQRPFKTTTQLAEAIAQTVPPKYRYGRIHPATRVFQALRIAVNEELSSLERFLDQAPQWLQPGGRIGIISFHSLEDRIVKYRFRDSSWLTVMTKKPIIPQREEQLKNPRSRSAKLRLAERHLV
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_MICAN
Sequence: MNIAVVGLSHKTAPVEIREKLSIPEAKIESALTHLKGYPHIQEVAIISTCNRLEIYAVVTDTEKGVVEITQFLAEIGHIPLNVLRRYLFTLLHQDAVRHLLRVSAGLESLVLGEGQILAQVKNTHKLAQKYNTISQLLDRLFKQAMTAGKRVRTETSIGTGAVSISSAAVELAHAKVTDLSSKKIAIIGAGKMSRLLVTHLLAKGSQQIAIINRSQRRAQELAREFPHLPLQLYGLEEMMTTVAASDIVFTSTGATEPILTKTLLTEVTITANSLMLIDISVPRNVHTDVKELAQVQAFNVDDLKAVVAANQESRRQMAREAEALLEQEVEAFELWWRSLDTVPTISCLRSKIEDIREQELEKALSRLGTEFAEKHQEVIEAMTRGIVNKILHEPMVQLRAQQDIEARKRCLQSLQMLFNLSVGEEYS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: NFUA_ECOL6
Sequence: MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEATDTALKFDLLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVADDAPLMERVEYMLQSQINPQLAGHGGRVSLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEKQLLNEFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: CHT_FUSSL
Sequence: MPITKYKAAAVTSEPGWFDLEAGVVKTIDFINEAGQAECKLVAFPEVWIPGYPYWMWKVTYLQSLPMLKKYRENSLTVDSEEMRRIRRAARDNQIYVSLGFSEIDHATLYLAQVLIGPDGSVVNHRRKIKPTHVEKLVYGDGPGDTFMSVSETDIGRVGQLNCWENMNPFLKALNVSCGEQVHIAAWPVYPGRERQVAPDPATNYADPASDLVTPEYAIETGAWTLAPFQRLSVEGLKKNTPEGVEPETDPSVYNGHARIYRPDGSLVVKPDKDFDGLLFVDIDLNETHLTKVLADFAGHYMRPDLIRLLVDTRRKELITEADPVGTIATYTTRHRLGLDKPLDGEKKEKEATKGRDSEAEEL
What is the function of this protein?
Catalyzes the hydration of cyanide to formamide.  Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.  Also able to transform metal cyanides.
What are the official names of this protein?
Cyanide hydratase, CHT, Cyanide-degrading nitrilase, Formamide hydrolyase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: AFF1_MOUSE
Sequence: MAAHSSLYNEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFPEPYKTAKGDELSSRIQTMLGDYEEMKEFLSSKSHPHRLDGSEDRPGKPRYPLGHDRGNGAASSSLRTHVYHQPIHTSAPGSRPVGNISHSPKMAQPRMEPSLHTKIYDGPRLTQDHLSQGHCSRKCDRRAEGDSAPERKLSPLISSLPSPVPPLSPVHSRLQGTSKAHSSGVSSKSCCVAKSSKDLVAKAQDKETPHDGLVAVTSLGSAPPQPPCQTFPPPPLPSKSAAMQQKPTAYVRPMDGQDQAPSESPELKLPLEDYGQQSFEKPDLKVPAKAKLTRLRMPSQSVEQPYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSRFPFPTKDPLHVSPATQSQKQYDTPSKTHPNPQQGTSMLEDDLQLSDSEDSDTEQATEKPPSPPAPPSAPQTLPEPVASAHSSSGESESSESDSSSDSESESSSSDSEEEEENEPLETRAPEPEPPTTNKWQLDNWLTKVNQPSVPLDGRGSTESPQWRQESKGVAEGSSDQQHPDSKDPLPKSSSKTLRGPSEGPSLGRGAVRNPPLNRNPHLGKPWAANNPGNPPRLRPGRAQASSQAESEVGPLPYGSKEQTSKDRPKVKTKGRPRAVGSREPKPEVPAPTPQAAVPRPKPPVPTPSEKRKHKSSTAPSKAPSAPQPPKDSAGDRNPEHSALVSLTQSQGPSHSSRGSSGSVRTSGCRQAVIAQGDGCKDKLLLPLRDTKLLSPLRDSPPPTSLVVKITLDLLTRIPQPLGKGSRPRKAEDKQLSAGKKQDSETKSCDSSSRVTKKRKVTQKKSTVTRDTNWISRRASSSSSHTESSRTKAPRSSSENSRKEMLPPASASSVSSSSSSQKPSRPAQKRPRPDEDTCSQEPPRSASSTKSSSTDPPAPKHRKVQARGSEHKGSSGDAANAANPFPVPSLPNGNAKPGKPQVKSDRQQADFHMKEAKKLKCKAETMVDKAGKAFKYLEAVLSFIECGMASESESSAKSAYAVYSETIDLIRYVMSLKCFSDNTMPAQEKIFAVLCLRCQSLLNMAMFRCKKDTVMKYSRTLSEHFKSTSKVAQAPSPCTARSTGVPSPLSPMPSPASSVGSQSSAGSSMGSVGVTATVSTPVSIQNMTSSYVTITSHVLTAFSLWEQAEALTRKNKEFFAQLSTKVRVLALNSSLVDLVHYTRQGLQRLKQSPKGP
What are the official names of this protein?
AF4/FMR2 family member 1, Proto-oncogene AF4, Protein AF-4.
What is the protein family that this protein belongs to?
Belongs to the AF4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRUD_SALEP
Sequence: MTEFDNLTWLHGKPQGSGLLKANPEDFVVVEDLGFTPDGEGEHILLRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDFSAFQLEGCKVLEYARHKRKLRLGALKGNAFTLVLREISDRRDVETRLQAIRDGGVPNYFGAQRFGIGGSNLQGALRWAQSNAPVRDRNKRSFWLSAARSALFNQIVHQRLKKPDFNQVVDGDALQLAGRGSWFVATSEELPELQRRVDEKELMITASLPGSGEWGTQRAALAFEQDAIAQETVLQSLLLREKVEASRRAMLLYPQQLSWNWWDDVTVELRFWLPAGSFATSVVRELINTMGDYAHIAE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: HISZ_SINFN
Sequence: MPLINLPAFAGDLLADFERLKTLRVDTPVIQPAEPFLDMAGEDLRRRIFMTQSETGDSLCLRPEFTIPVCLRHIETATGTPQRYAYLGEVFRQRREGSSEFYQAGIEDLGDTDTAGADARAIGDAMRVLSNRLANRRLKVTLGDQSVFEAVIAACGLPGGWQKRLIHAFGDPKQLQKLLGELADPKSPGVFGHEVERLAILGILDDEERLVAHLAETMEATGYSTNASRSPRDIARRLKEKMELATTRLDRAALAVMREFLAFDLPLSEAPAALHAFAKKSRLKIDDALSLFDARVAAIAKVGAESDLIRYRAAFGRPLDYYTGLVFEIEAEGAPAVLAGGGRFDRLLTLLGAREHIPAVGFSLWLDRIERAIAAAGGA
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ3_YEAST
Sequence: MLLRSRFLKVIHVRKQLSACSRFAIQTQTRCKSTDASEDEVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKIQNPEIFVPGFNYKEFLPEYVCDNIQREMQESIETNLDKRPEVSVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEGKINYECKALEDVTGQFDIITCMEMLEHVDMPSEILRHCWSRLNPEKGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNYSGQFRLLDLKGTMYLPYQGWVEHDCSDVGNYFMAIQRLN
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.  Catalyzes the methylation of 3,4-dihydroxy-5-hexaprenylbenzoate (DHHB) to 3-methoxy-4-hydroxy-5-hexaprenylbenzoate (HMHB) and the methylation of 2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol (3-demethylubiquinol-6) to ubiquinol-6.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, mitochondrial, 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, DHHB methyltransferase, DHHB-MT, DHHB-MTase, 3-demethylubiquinol 3-O-methyltransferase, 3-demethylubiquinone-6 3-O-methyltransferase, Hexaprenyldihydroxybenzoate methyltransferase, Polyprenyldihydroxybenzoate methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: GLRX5_YEAST
Sequence: MFLPKFNPIRSFSPILRAKTLLRYQNRMYLSTEIRKAIEDAIESAPVVLFMKGTPEFPKCGFSRATIGLLGNQGVDPAKFAAYNVLEDPELREGIKEFSEWPTIPQLYVNKEFIGGCDVITSMARSGELADLLEEAQALVPEEEEETKDR
What is the function of this protein?
Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:11950925, PubMed:12730244, PubMed:23615440).  Receives 2Fe/2S clusters from scaffold protein ISU1 and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:27532773, PubMed:23615440).
What are the official names of this protein?
Monothiol glutaredoxin-5, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family. Monothiol subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: EIF3H_HUMAN
Sequence: MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815).  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit H, eIF3h, Eukaryotic translation initiation factor 3 subunit 3, eIF-3-gamma, eIF3 p40 subunit.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CITD_SHIFL
Sequence: MKINQPAVAGTLESGDVMIRIAPLDTQDIDLQINSSVEKQFGDAIRTTILDVLARYNVRGVQLNVDDKGALDCILHARLEALLARASGIPALPWEDCQ
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_STRMK
Sequence: MTPILFIDRDGTLIEEPSDFQIDAYEKLRFVPQVIPALLKLRDAGYQFVIVTNQDGLGSDSYPRASFDGPNELMLQIFESQGITFRDVLIDCSWPQDNAPTRKPGIGLMTAYLQDRSIDWARSGMVGDRITDLQFADNLNIRGFQLRTAQFGGQWDWPGIAHALADAPRTAVVQRDTKETKIRVELDLDRAADAHISTGLPFFDHMLEQIGKHGGFALDIQAEGDLHIDEHHTIEDTGLALGQALREALGDKRGIGRYGFTLPMDETLASAALDFSGRPYFVFEGEFKRERVGDMPTELVPHFFRSLCDASGLNLNLQVRGDNDHHKVEACFKALARALRPALARQGTALPSTKGAL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_STAPU
Sequence: MEKKTGLIQFLSEWKCVDDQPDHNRRLHYSRFALSPLLVDQAMTIGVAIRRALLSEVEGISIISANIVGAVHEYSTLDGVRESVDEILLNLKQIVIKGAKGASITPLDHKEYRASIFAQGPGVVTAEHIKFPSSILAVDPDQSIATLLNETQLCIELFIRQGIAKQLTRTKKNHQGFFIDANFTPVQKANFSIHSVGDPKGLQQLLLLEIWTNKTLTPAEALYQAHASLLNLFHQISPPLLHKELSPSKNILNQNSDSNSLGGSSFGRVVSLETRRDSTQTNNSSIPKEIQPSVRLKSYTDTNLSIDKQMNDSVNKENLSIDELELSPRISNCLKKANINTIADLLNYTQEDLLKIKNFGRKSVEQVSLVLRKRFNMELLPTK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LEM3_LEGPH
Sequence: MKLRYIINENKLVFTSCNMRDKIITGKKIIFSQSVAKDQTKNLSSFLSERFYSVNQSHNHSIIIGSSLSHQENDIEHDTILDTSGVLVTTDTNGIVNGARVAITDGLGGGNGDQEEDDEIYRVSHSSCENFLNCDQNIDTTLSLITQPKASDKKQTAPKTLQHTEASMAAFIYQNHPGKGYIGEFANIGDGLIIILDKRFKIKHMVSACHIYRGFGTWTPPSLQALATTANKDALLVRQTLKLAEGDIIISMTDGVWGELKTSLIAQTNDRRDIGVDKEYFKTLFDELTDAPYPSSFDIARIITQRAMSRSLERRKTLIKLINEIEQQHFHEKSVKTINEVLEYFIKTGHVETAQTLKAILFEDGLSDGITYFENIEIPLEMVMHDLKSRTVGDCSTINVTRIPYHLDELIRGFINYPEKHQILAPLFKARVKSEADLEEAFHRLSLEMVQPEIECPISETHFERAFKKETLDKTQAVLTHYFRISTGLDSKKNYQERLNDLSAYLSKESSLEKNDIKLLLSMLDSEIKPKTGVFQTLFGENQNKLYKAFHKKIELQLLDSEIENKNELK
What is the function of this protein?
Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs).  Acts as a phosphocholine hydrolase by mediating the hydrolysis of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C).  Dephosphocholination of target proteins restores accessibility to GTPase effector LepB.  Can act on both GDP-bound and GTP-bound Rab proteins.
What are the official names of this protein?
Phosphocholine hydrolase Lem3, Dephosphocholinase Lem3.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Note=Translocated into the host cell via the type IV secretion system (T4SS).
Protein: VDLD_HELPY
Sequence: MPQIQSSHSNHFDFTIDTADRTKLLMSYLVVPTTANFNNVMHGGELLNLLDKVAYVCSTRYCAKGTVTLSVDGVTFKYPIPVGNLLTFLASINYVGNTSCEVGIKVLSEDIKTREITHTNSCYFTMVAVENGKPTPMPKYEPKTEVEIRRYEGALKRKEMRTRGYLKSGKHEGV
What are the official names of this protein?
Protein VdlD.
What is the protein family that this protein belongs to?
Belongs to the acyl coenzyme A hydrolase family.
Protein: SYI_HELPH
Sequence: MEEYKDTLNLNTTTFSMKGNLSVNEPKTYAKWQEQQVFKRMQNRKDNHGDFTLHDGPPYANGHLHLGHALNKILKDIVVKREYFKGNKIYYTPGWDCHGLPIEQQILERLEKEKTSLENPTLFREKCRDHAKKFLEIQKNEFLQLGVLGDFEDPYKTMDFKFEASIYRALVEVAKKGLLKERHKPIYWSYACESALAEAEVEYKMKKSPSIFVAFGLKKESLEKLKVKKASLVIWTTTPWTLYANVAIALKKDAIYALTQKGYLVAKALHEKLAALGVVDSEIAHEFNANDLEYLKASNPLNQRDSLITLGEHVGLEDGTGAVHTAPGHGEEDYYLGLRYNLEVLMSVDEKGCYDEGIIHNQLLDESYLGEHVFKAQKRIIEQLGDSLLLEQEIEHSYPYCWRTHKPVIYRATTQWFILMDEPFIQNDGSQKTLREVALDAIEKVEFVPSSGKNRLKTMIENRPDWCLSRQRKWGVPLAFFIDKRTNKPCFESEVLEHVAHLFEKKGCDVWWESSVKDLLPPSYQEDATHYEKVMHILDVWFDSGSTFKAVLEDYHGEKGQSPSDVILEGSDQHRGWFQSSLLIGCVLNNQAPFKKVITHGFIVDEKGEKMSKSKGNVVSLDNLLKKHGSDVVRLWVAFNDYQNDLRVSQTFFIQTEQHYKKFRNTLKFLLANFSDMDLKNLERSHNFSPLDHFILEALETISVGVNSAFEEHDFVKGLNVLMAFVTNELSGIYLDACKDSLYCDSKNNEKRQAIQMVLLATASKLCYFLAPILTHTIEEVLEHSQVLCAFLQAKDVFDLKDISVSEKLHLKEFKKPENFEAVLALRSAFNEELDRLKKEGVIKNSLECAIEVKEKALRENLVEELLMVSFVGIAKEKLSETPAFTLFKAPFYKCPRCWRFKSELENTPCKRCEEVLKER
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRAW_ECOLI
Sequence: MRCRGLIALLIWGQSVAAADLGTWGDLWPVKEPDMLTVIMQRLTALEQSGEMGRKMDAFKERVIRNSLRPPAVPGIGRTEKYGSRLFDPSVRLAADIRDNEGRVFARQGEVMNPLQYVPFNQTLYFINGDDPAQVAWMKRQTPPTLESKIILVQGSIPEMQKSLDSRVYFDQNGVLCQRLGIDQVPARVSAVPGDRFLKVEFIPAEEGRK
What is the function of this protein?
Involved in F-pilus assembly.  Required for F plasmid conjugative transfer.
What are the official names of this protein?
Protein TraW.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLUQ_CORDI
Sequence: MGTFQGAGRYAPSPSGDLHFGNVRTAVLAWLFARHTGRRFLIRVEDVDTQRSSLESAARQLEDLHALGMDWDAAPTYQHNNFDRYEQALRNLPHYECYCSRKDIQEASRAPHTIPGQYPGTCRNLTEVQREERRQALAKQGRVPALRLRADVPTWHVRDYYAGDVLGDVDDMILRRGGQQPDWAYNLAVVVDDAADGIDQVVRGNDLLTSAPRQAYLAHLLGVPAPTYVHVPLVLNAAGQRLAKRDGAVTMREMPDILPRVAESLGLSARTLPGMLEEFDPDRFSQQPWIFAIHKEV
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.