PharMolix/UniProtQA huggingface dataset:
Protein: LEG1_PIG
Sequence: MACGLVASNLNLKPGECLKVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFDMHGDINTIVCNSKDGGAWGAEQRESAFPFQPGSVVEVCISFGQTDLTIKLPDGYEFSFPNRLNLEAIEHLAADGDFKIKCVAFE
What is the function of this protein?
Lectin that binds beta-galactoside and a wide array of complex carbohydrates.  Plays a role in regulating apoptosis, cell proliferation and cell differentiation.  Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.  Strong inducer of T-cell apoptosis.
What are the official names of this protein?
Galectin-1, Gal-1, Lectin galactoside-binding soluble 1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Cytoplasm. Secreted. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: HOA2_PSEPW
Sequence: MINTNKKIHISDVTLRDGMHAVRHRYSLEQVAGIAQALDQAGVDSIEVAHGDGLQGSSFNYGFGAHTDFEWIAAVAAVVQRARIATLLLPGIGTVHDLKAAYDAGARIVRVATHCTEADVSRQHIEYARSLGMDTVGFLMMSHMQTPAGLARQGKLMESYGAQCIYVVDSGGAMNMWDIAERFKAMKDVLDPATQTGMHAHHNLSLGVANSLVALEHGCDRVDASLTGMGAGAGNAPLEVFAAAAERMGLNHGCDVKKLIDAAEDIVRPLQERVVRVDRETLALGYAGVYSSFLRHAEAAAAKYGLSTFDILVELGKRRMIGGQEDMIIDVALDLLNQG
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 2, HOA 2, 4-hydroxy-2-keto-pentanoic acid aldolase 2, 4-hydroxy-2-oxopentanoate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: C71CU_SINHE
Sequence: METFQCLTLFLLFISTVFILKRKFSHKPNLPPSPPKLPILGNFHQLGTLVHRAVTVLAAKYGPLMLLHFGKTPVLIVSSQETAKEIMKTHDLALANRPLTTAARALLYDCTDISFAPYGEYWREMKKMAVLNLLSIKKIQSFRSVREELASDMIKEITRLSKTGAPVDVTNMLYHFSEDLLFRCTLGFKPKGQHKFQKLSRDFLDLVGAFCFNDFFPGMAWMDALTGLNRKLKKGSRELDDFVDELIEERIAMVKDGVEPNEFLDLLLHTHRDTTQEIKLTRDNVKAIILDTFLGGIDLPASVMEWAMAELMRNPSKMKIAQEEVRKVVGNKNKVDEDDVYQMNFLKSAVKETLRLHPPAPLLFARESYTSINVENYIIPPYTSVMINIWHIQRDPKLWDKAEEFIPERFMNSGIDYKSHDYEFIPFGSGRRGCPGMSFGVAAVEFAVANLLYWFDWKFVGDTTPETLDMTEDYCFALFKKKPLHFIPISRSS
What is the function of this protein?
Cytochrome P450 involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family (PubMed:26359402).  Catalyzes the conversion of bursehernin to demethylyatein (PubMed:26359402).
What are the official names of this protein?
Desmethylyatein synthase, Cytochrome P450 family 71 subfamily CU polypeptide 1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NU3M_BOSMU
Sequence: MNLMLALLTNFTLATLLVIIAFWLPQLNVYSEKTSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTTNLNTMLTMALFLIILLAVSLAYEWTQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LIPA_FLAPJ
Sequence: METVLDSNILPVGKPKWLKVKLPIGQKYTELRGLVDKYKLNTICTSGSCPNMGECWGEGTATFMILGNICTRSCGFCGVKTGRPETVDWDEPEKVARSIKIMNIKHAVITSVDRDDLKDMGSIIWIETVKAIRRMNPETTLETLIPDFQGVERNLDRIVAANPEVVSHNVETVRRLTREVRIQAKYDKSLEVLRYLKAKGIKRTKSGIMLGLGETEEEVIQTMRDLREANVDIVTIGQYLQPSKKHLPVKEFITPEQFEKYELLGKEMGFRHVESGPLVRSSYHAQKHIL
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_RICM5
Sequence: MMSQNYYQILGVSKTASQADLKKAYLKLAKQYHPDTTDAKDAEKKFKEINAAYDVLKDEQKRAAYDRLGHDAFQNQQSRGGGGNHGGFHPDINDIFGDFFSDFMGGSRRSSRPTSAKVRGSDLKYNLTINLEEAFHGIEKNISFSSAVKCDTCHGSGSEKGETVTTCDACSGVGVTRMQQGFFTIEQACHKCQGNGHIIKKPCKKCHGMGRYHKQRNLSVNIPAGVENGTRIRHTGEGEAGIRGGNSGDLYVDIAIKPHDIYKVDGAHLHCKLPISFVNAALGGEIEVPVIEGGKVKLTIPAGTQNGDQLRLRNKGMSKMRSTIRGDMLTHMHVEVPKNLSKRQRELLEEFKKESINEKENDGSFFNKMKSLWS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSRA_ENT38
Sequence: MTVLIEAHGIHKQFSGVPVLRGIDFTLLSGQVHALMGGNGAGKSTLMKIIAGVETPDSGELNVEGKPFARLKPGQAHQLGIYLVPQEPMLFPNLTVRENILFRLPRGNDPEKRLADKLQQLQCQLNLDAAASTLEVADQQMVEILRGLMRDAKILILDEPTASLTPGETERLFRQIRALQDLGVGIVFISHKLPEIRQLASHVSVMRDGAVVLSGETTQFDDTALITAMTPVSREQGLSDTQKLWLALPGNRRTQAQDFPVLRVEDLTGEGFIDLSLEIYAGEIVGLAGLVGSGRTEFAETLYGLRPTRGGRIWLENQEIGEDSVLTRLEKGLVYLPEDRQVSGLFLDAPIRWNTVALNEPSLWQQRKREAAVVERYHRALGIKLNHPDQIVRTLSGGNQQKVLLARCLEANPLLLIVDEPTRGVDVSARADIYQLIKSVAAQNVAVLMISSDLDEFPGLADRVLVMHQGMFSGELPRHAVSLDRMMALAFGGQS
What is the function of this protein?
Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Autoinducer 2 import ATP-binding protein LsrA, AI-2 import ATP-binding protein LsrA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS7_BACAC
Sequence: MPRKGPVAKRDVLPDPMYNSKLVTRLINKMMVDGKKGKSQTILYNAFDIVSERTGKEPMEVFEQALKNIMPVLEVRARRVGGANYQVPVEVRPERRTTLGLRWLVNYARLRGEKTMEERLANEILDAANNAGASVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RS20_ERWT9
Sequence: MANIKSAKKRAVTSEKRRKHNASRRSMMRTFIKKVYAAIATGDKAAAQNAFNEMQPLVDRQAAKGLIHKNKAARHKANLTAQISKMA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: CHLL_PLETE
Sequence: MKLAVYGKGGIGKSTTSCNISIALARRGKKVLQIGCDPKHDSTFTLTGFLIPTIIDTLQSKDYHYEDVWPEDVIYQGYGGVDCVEAGGPPAGAGCGGYVVGETVKLLKELNAFYEYDVILFDVLGDVVCGGFAAPLNYADYCIIVTDNGFDALFAANRIVASVREKARTHPLRVAGLVGNRTDARDLIDKYVEVCPMPVLEVLPLIEDIRISRVKGQTLFEIAETQTAVSYVCDYFLNIADQLLSQPEGVVPNELGDRELFSLLSDFYLNPTSNSEKNANISGLEPDSLDFLIV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y3201_RHOP2
Sequence: MTEAAPTRIYVDADACPVKDEIYRVAERHGLPVSVVAGSFIRVPTHPLIERIAAGSGMDAADDWIAERVQPGDIVVTADVPLASRCVKAGAEVLAPNGKPFSEESIGMTLAVRNLMTDLRSSGEITGGPRGFTPRDRSAFLAALDTTIRRIARRRPSPPAQPQT
What are the official names of this protein?
UPF0178 protein RPB_3201.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: UXAC_ECO57
Sequence: MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHALDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMSGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: RNZ_CHLAB
Sequence: MSCRELVILGCSSQQPTRTRNQGAYLFRWNNEGLLFDPGEGTQRQFIFANIAPTIVSRIFISHFHGDHCLGLGSMLMRLNLDKVTHPIHCYYPASGKKYFDRLRYGTIYHETIRVIEHPIDKEGIVEDFGNFRIEARKLNHLVDTLGWRITEPDTIKFIPEKIKAAGLRGPIMQDLLRNEHVTVNGKTLYLKDLSYIRKGDSIAVIADTLPCPSIVDLAKNARIMLCESTYLEEHSHLAESHYHMTAKQAATQALAAGAQQLVLTHFSARYLNSKEFEIEAGKIFPNVTAAEEFRSYPFPKNPSSK
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: CH10_STAAU
Sequence: MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKEGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10, Heat shock protein 10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CQ100_MOUSE
Sequence: MGRMASPLRSKSSAPRVESTRHKETSTVRVETSSHREETSSHRVETSSRQVRTSSRQVETSQRHREGPSLTPSTKRLPQFLEVSSQHVETSSQCTETSSRHVRASSSLRVETTVHRVESPARQSARMAR
What are the official names of this protein?
Uncharacterized protein C17orf100 homolog.
Protein: GLPK_LEPBP
Sequence: MAKKNYIIGIDAGTTGIRTFCFNDKGKVISSAYQEFKQYYPKPGWVEHDPEEIWVKTQKLITLAIKNGKLNPKDAVAIGITNQRETSVVWDKKTGKPVYNAIVWQCRRTSDICKDLKKQSLDSNFRNKTGLVLDAYFSGTKIQWILDNVKGARDRAERGDLLFGTIDTWLLYKLTGHKEHKTDHTNASRTLLFNIQTKEWDEELCKILRVPMSMLPKAFNSKNLFGFTSNVKSIPDGIPISSLVGDQQGALFGQLCTEPGEAKNTYGTGCFLLFNVGDEFRISNQGLITTLALGPEGKTVYCLEGSVFIGGAVVQFLRDNLEFFKYSKDSEKLVKSIKTKDDIVFVPAFAGLGAPHWDQEARGAIFGLSRDTTPAQITRAALKAIALQSYELANAMEKETGKPLKFLRVDGGATSNAWLMQFQADILGTKVIRPQNVDTTVLGAAYLAGLERGFFKSVAHLRKEETKTTQFTPKMKESERKEEIDKWNLAISRVKTET
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RDRP_I96A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLKRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKGEMEIITHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIEAGVDRFYRTCKLVGINMTKKKSYINRTGTCEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMMDNDLGPATAQMALQLFIKDYRYPYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNPYNIRNLHIPEAGLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELGRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: RS14_BACP2
Sequence: MAKKSKIAKEKKRQQLVLKYAELRKELKEQGDYEALRKLPRDSSPTRLKNRCELTGRPRGYLRKFKMSRIAFRELAYKGHIPGVKKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: ARP8_YEAST
Sequence: MSQEEAESSIIYEEPIDIPLEDDDDEDELEEENSVPLSSQADQENAENESDDSVDNVVGSETPRSVTGLSVDPRDVADEEDEDEEGEDEDEDEDDNDVDNEDENDNDNANENENELGSSRDKRAPPAVQTSKRYKKYPKLDPAKAPPGKKVPLHLLEKRRLGRIKAAEEFAKTLKKIGIEKVETTTLPATGLFQPLMLINQKNYSSDYLKKDDQIFALRDRKFLRNNNTSQISSTNTPDVIDLKSLPHSEASAAPLNDEIDLNDPTATIVIHPGSNSIKIGFPKDDHPVVVPNCVAVPKKWLDLENSEHVENVCLQREQSEEFNNIKSEMEKNFRERMRYYKRKVPGNAHEQVVSFNENSKPEIISEKNDPSPIEWIFDDSKLYYGSDALRCVDEKFVIRKPFRGGSFNVKSPYYKSLAELISDVTKLLEHALNSETLNVKPTKFNQYKVVLVIPDIFKKSHVETFIRVLLTELQFQAVAIIQESLATCYGAGISTSTCVVNIGAAETRIACVDEGTVLEHSAITLDYGGDDITRLFALFLLQSDFPLQDWKIDSKHGWLLAERLKKNFTTFQDADVAVQLYNFMNRSPNQPTEKYEFKLFDEVMLAPLALFFPQIFKLIRTSSHKNSSLEFQLPESRDLFTNELNDWNSLSQFESKEGNLYCDLNDDLKILNRILDAHNIIDQLQDKPENYGNTLKENFAPLEKAIVQSIANASITADVTRMNSFYSNILIVGGSSKIPALDFILTDRINIWRPSLLSSASFPQFYKKLTKEIKDLEGHYVNAPDKTEDENKQILQAQIKEKIVEELEEQHQNIEHQNGNEHIFPVSIIPPPRDMNPALIIWKGASVLAQIKLVEELFITNSDWDVHGSRILQYKCIFTY
What is the function of this protein?
Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.  Exhibits low basal ATPase activity, and unable to polymerize.  Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
What are the official names of this protein?
Actin-like protein ARP8.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton.
Protein: S28A2_HUMAN
Sequence: MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPNTSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
What is the function of this protein?
Sodium-dependent and purine-selective transporter (PubMed:9435697, PubMed:10087507).  Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:9435697, PubMed:10087507, PubMed:21795683).  Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues (PubMed:9435697).  May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).
What are the official names of this protein?
Sodium/nucleoside cotransporter 2, Concentrative nucleoside transporter 2, CNT 2, hCNT2, Na(+)/nucleoside cotransporter 2, Sodium-coupled nucleoside transporter 2, Sodium/purine nucleoside co-transporter, SPNT, Solute carrier family 28 member 2.
What is the protein family that this protein belongs to?
Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HMBX1_CAEEL
Sequence: MLFTIEQLELIKKLQHTGMSSDQLLKAFGELEVPEQLQNNNTIAAALYSPLLVQHLTTPKSETPVKLTVQTVPTPVKSEPQSSNCSSPFEHPICSNAPRPIRSQRTPMKEITTLDDPNELEEFMKQGEEACILDMKTFITQYSLRQTTVAMMTGVSQPYISKLLNGNHRELSLRCRKNIYCWYLNCRRHPNKLAAFLADPTTRLETNGDGELIPQRRERYVFRPILIRMLESFFTQTPFPDLPRRVEIANACNHVLKMDKKGVGLMPKEVVSPQVVSNWFANKRKELRRRSAEASAASTSSASSSASSTANHDSVSVSSMSPRDEETSSRNTTPETAISPSPAVSTFEVSRPSAIISATSSTTSPISIPATIIPSVSPSALELFAMAQQLGVQLPVPFPTLPTHFFPFQMAPFYGNPASILKSE
What is the function of this protein?
Transcriptional repressor which maintains cell fate asymmetry of AWC neurons in adults by repressing the expression of multiple AWC (OFF) genes, including srsx-3 in the AWC (ON) neuron.
What are the official names of this protein?
Homeobox-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the HMBOX1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL37A_MOUSE
Sequence: MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:36517592).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592).
What are the official names of this protein?
60S ribosomal protein L37a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YD13B_YEAST
Sequence: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPNSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIQQCGMEEVRGWSCVFKNSQVTICLFVDDMVLFSKNLNSNKRIIEKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKHKTSSDKNI
What is the function of this protein?
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane.  Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity).
What are the official names of this protein?
Transposon Ty1-DR4 Gag-Pol polyprotein, Gag-Pol-p199, TY1A-TY1B, Transposon Ty1 TYA-TYB polyprotein, p190.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MFA1_PORGN
Sequence: MKLNKMFLVGALLSLGFASCSKEGNGPAPDSSSTADTHMSVSMSLPQHNRAGDNDYNPIGEYGGVDKINDLTVYVVGDGKIDVRKLSTADLQVNQGASTTSIVTAPFQVKSGEKTVYAIVNITPKVEAALNAATNAADLKVAYEAAYAAFSDAGSEIATLVNNQDQMIMSGKPVVQTILPNVSAANASVQNKVPIIVKRAAIRASMTITQQPVNGAYEIKALRPGNVEVVIATVSDLKWSVAQYEKKYYLQQKDNALSPAASFVPASTNDYNGANGAMKHYDYSQLANRITVHQLNAPYSVTDVPNVAYKYVSETTHADNDYRKGNTTYILVKGKLKPVAAMWADGEQAAYQEGGDLFLGLVTGKFYANEANANAANPASGGAGNPRVVTYKAAAVYYYAWLNPNTLDPTTWTMSPARRNNIYNVNISKFRNIGLSGNPFVPTDPDPNNPDTPDNPDTPDPEDPDTPNPEEPLPVQKTYMVVDVTVTPWTLHNYDIEF
What is the function of this protein?
Structural subunit of the minor fimbriae (PubMed:26001707).  These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome.  They play an important role in invasion of periodontal tissues and are recognized as major virulence factors.  Mfa1 orthologs from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).
What are the official names of this protein?
Minor fimbrium subunit Mfa1, 53 kDa fimbrilin.
What is the protein family that this protein belongs to?
Belongs to the bacteroidetes fimbrillin superfamily. FimA/Mfa1 family.
What are the subcellular locations of this protein?
Fimbrium. Cell outer membrane. Note=Probably synthesized as a palmitoylated precursor. Efficient export to the outer membrane and integration into fimbriae requires lipidation and subsequent proteolytic removal of the lipidated propeptide (Probable).