PharMolix/UniProtQA huggingface dataset:
Protein: PYRK_STRR6
Sequence: MIRLETMKVVAQEEIAPAIFELVLEGEMVEAMRAGQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIEGAGTAIFSTLSQGDTLDVMGPQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILKTELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHPRAYLSLESRMACGMGACYACVLKVPESETVSQRVCEDGPVFRTGTVVL
What is the function of this protein?
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit, Dihydroorotate oxidase B, electron transfer subunit.
What is the protein family that this protein belongs to?
Belongs to the PyrK family.
Protein: DNAA_SHEON
Sequence: MAVSLWQQCIGRLQDELSAQQFSMWIRPLQAEMDGDTLVLYAPNRFVLDWVRDKYINIINQFFTEQMGNDAPKLRFDIGSRPSAKKPEPAPVAAVRVPSPQTKASVGTAFNTTEPVANTNHRSNINPTYQFDNFVEGKSNQLGKAAALQVAENPGGAYNPLFLYGGTGLGKTHLLHAVGNGIIKNNPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALFIDDIQFFANKDRSQEEFFHTFNALLEGNHQIILTSDRYPKEIDGVEDRLKSRFGWGLTVAIEPPELETRVAILMRKAQESGINLPDEVAFFIAKRLRSNVRELEGALNRVIANANFTGRPITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKMADMLSKRRSRSVARPRQVAMALSKELTNQSLPEIGDAFGGRDHTTVLHACRKIAQLREESHDIKEDYANLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB2A_MESAU
Sequence: SCLLLQFTDKRFQPVHDLTIGVEFGARGAAGALLVYDITRRTASNVEEAFINTAKEIYEK
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between active GTP-bound and inactive GDP-bound states.  In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.  Required for protein transport from the endoplasmic reticulum to the Golgi complex.  Regulates the compacted morphology of the Golgi.
What are the official names of this protein?
Ras-related protein Rab-2A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity).
Protein: RSMB_PECAS
Sequence: MKSSYNLRSIAAKVVGQVLDQGQSLSALLPIHQRDVSDKDRALLQELCFGVLRVLPQLEWCIQQLMAKPLTGKQRTLHYLIMVGIYQLHYTRIPPHAALAETVEGAVALKRPQLKGLINGVLRQFQRQQEELLQREATHSSHYLHPSWLLARIEHAYPNNWRGIVEANNQRPPMWLRVNRLHHTREAYLNLLMQGGIEAFPHTEYSDAIRLASPCAVDQLPGFSQGWATVQDASAQGCVYWLDPQDGEQILDLCAAPGGKTTHILEAAPKSHVLAVDVDETRLGRVKENLLRLQMHAEVKQGDGRYPDSWCEARVFDRILLDAPCSATGVIRRHPDIKWLRRDRDIEELVALQKEILDAIWPHLKTGGTMVYATCSILPQENTQQVTGFLSRHADAALVDTGTSEIPGIQILPHADSGDGFFYAKLVKN
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_BORBU
Sequence: MIKRVHLGQGRADEILDLPNLIEIQLNSYEKFLQLDKLKSKKPLLNEGLESVFRNIFPIKSGNGDVALEYERYYIENDALNFTEKECKRKGQSYEAVLKVRLNLQFLTTGEIRQKDVYMGTIPLMTERGTFIINGAERVVVSQIHRSPGVVFYKEKDLYSARIIPYRGSWLEFEIDSKKDYLYVKIDRKKRILITLFLRALGFDTREKIIETFYNIKKIKVEDGTKRDLPGQYLAKSINIRENMYYRAGDKITLQDVEDFLQNGVNEIELVDFDGYNDISGKRFVSSNVILNCLEKEDAFFALKDGSKELPKESVMLAVYGSLFPGEPISIDNAENDLKTIFFSERRYDLGRVGRYKLSKKFGFDDLTTSVLTMDDIVNTISHLLRIYEGHDILDDIDHLGNRRVRSVGELLTNIYKGAMSRVEKIAKDRMSNKEVFNLKPQELISVKPIVSAVKEFFATSQLSQFMDQVNPLAELTHKRRLNALGPGGLSRDRAGFEVRDVHYTHYGRMCPIETPEGPNIGLIVSLATYSRVNDYGFLETPYRKVVNGVVTDQLEYLSAIDEEKKCIAQANAAFNSNGKYLEDLVSVRISGDYTTTSPTNIDYMDVSPRQLISVSSALIPFLEHNDANRALMGSNMQRQAVPLLFPKPPIVGTGMESVVAKDSGVVVKAKRSGEVILATSSKIVVKPFEAENAKDLDEYHIVKYERTNQDTCFNQSVLVKEGQKVERGEIIADGPATRYGELALGNNLLLGVIPWNGFNYEDAILISDRIVKEDLYTSIHIKEFSIEVRETKLGPEKVTGDIPNVSEKILNKLDENGIIRIGTYVKPGDILVGKVTPKSEGDITPEFRLLTSIFGEKAKDVKNNSLKVPHGTEGTVIDVQRITKEDVGNLSPGVEEILKVYVAKKRKLKEGDKMAGRHGNKGVVAKILPVEDMPYLADGTPLDICLNPLGVPSRMNIGQLMESQLGLAGKYLGESYNVPVFESATNEQIQEKLKTAGFNPTSKEILYDGYTGEPFENEVMVGVIYMLKLHHLVDDKMHARSTGPYSLVSQQPLGGKAQFGGQRLGEMEVWALEAYGAAHTLQELLTVKSDDMSGRVKIYENIVKGVPTNVSGIPESFNVLMQELRGLGLDLSIYDDAGNQVPLTEKEEELINKS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: LIN22_CAEEL
Sequence: MTSFLCSDTEIESDGGISRCKKIKNKPLMEKKRRARINKSLSQLKQILIQDEHKNSIQHSKWEKADILEMAVEYLQQLRSAQPCSLSPSTSSISTPPTPKEEIRNIKVPLNPIASFLNPMMQQYVAYQQLAQLSMYTQLFNNPAGVPLRADAGVTAQSPELAEKLKIEDRSRV
What is the function of this protein?
Probable transcription factor (PubMed:9247331, PubMed:29108019).  During development, required for cell fate specification, probably by promoting or repressing expression of genes involved in specific cell fate (PubMed:9247331, PubMed:29108019).  Involved in specifying lineages derived from the epidermal stem cells of the lateral ectoderm, known as seam cells (PubMed:9247331, PubMed:29108019).  Modulates symmetric divisions of seam cells, perhaps in concert with the Wnt signaling pathway (PubMed:29108019).  May repress expression of homeobox genes mab-5, egl-5 and lin-39 (PubMed:9247331).
What are the official names of this protein?
Helix-loop-helix protein lin-22, Lineage abnormal protein 22.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPB_PELPB
Sequence: MQEGKISQIIGPVVDVDFPEGRLPSILDALTVTRADGTKLVLETQQHLGEERVRTVAMESTDGLVRGMNVTHTGKPIQVPVGLEVLGRMLNVVGDPIDGRGPVNTKKSYSIHRLAPRFDEISTKAEMFETGIKVIDLLEPYSRGGKTGLFGGAGVGKTVLIMELINNIAKQQSGFSVFAGVGERTREGNDLWHEMMESGVIDKTALVFGQMNEPPGARQRVALTGLSIAEYFRDEEGRDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGELQDRIVSTKKGSVTSVQAIYVPADDLTDPAPATAFAHLDATTVLSRSIAELGIYPAVDPLDSTSRILDPNIVGDDHYDTAQAVKQLLQRYKDLQDIIAILGMDELSDEDKLVVSRARKVQRFLSQPFFVAEAFTGLAGKYVKLEETIKGFKEIIAGRHDNLPESAFYLVGTIEEAVEKAKTL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: VATE_SULIA
Sequence: MDFEQLLDKSLNKVREEIKTELSKSLDEAIKLLNEGHTKIIQEYTQRINELITKTKEEIEGEKARLEVENKRTLLVEKEYWINKVYERVLEKIGEVVKTKEYKDAIQSILNKEIKEMEGEKITVYCSPNDKSTVEKVVGNNKNVTIKTDDKMLGGIRIYYEGSGLTRDFSLKLILDQVFDSMRGKISDMLFGGK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type proton ATPase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: YOBF_ECO57
Sequence: MCGIFSKEVLSKHVDVEYRFSAEPYIGASCSNVSVLSMLCLRAKKTI
What are the official names of this protein?
Protein YobF.
What is the protein family that this protein belongs to?
Belongs to the YobF/DUF2527 family.
Protein: SCX11_TITOB
Sequence: MTRFVLFISCFFLIGMIVECKDGYLVGNDGCKYNCLTRPGHYCANECSRVKGKDGYCYAWMACYCYNMPNWVKTWSRATNKCGKRK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Toxin To11, T NaTx14.9.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRC_LEIXX
Sequence: MSDETFVITGAMLADGSRTDLLLAGGRIQETGVRLSAAGATVVDADGLLALPGLVDLHTHLREPGYEQSETVLTGTRAAAAGGFTEVFAMANTSPVADTAGVVEQVLSLGEAAGYATVRPIGAVTVGLEGERLAELGAMADSRARVRVFSDDGKCVSDPLLMRRALEYVKAFDGVIAQHAQEPRITAGAQMNEGALSGELGLAGWPAVAEESIIARDVLLAEHVGSRLHVCHVSTAGSVDVIRWAKARGIDVTAEVTPHHLLLTEELVSGYDARYKVNPPLRRSEDVEALRAGLADGTIDIVATDHAPHPVEAKDCEWDAAAFGMVGLESALSVVQSSVVDTGMLGWADIARVLSATPARIGRLAGHGTPVEAGAPAELFLYDPAAAREFSTGELAGKGVNSPYLSMTLSGRVVATFHRGYATVLDGAVLESVGGARG
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: PYRB_FRASN
Sequence: MNHLLSTADLKLDDALLVLDTADRMARVADAPVRKLPTLRGRTVVNLFFEDSTRTRTSFEVAAKRLSADVINFSARGSSVSKGESLKDTAQTLEAMGADAVVCRHPASGAPHRLASWVRGSVVNAGDGTHEHPTQALLDAFTIRRRLGRLDGLAVTIVGDVLHSRVARSNVWLLTTLGARVTVVAPPTLLPLGISGWPVEVSYDLESVLPKSDVVMMLRVQRERMSAAFFPTEREYSRRYGLDADRAALMPEHALVMHPGPMVRGMEIASSVADSPRSTVVEQVANGVSVRMAVLYLLLGGSGAERESS
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: FENR_IMPCY
Sequence: LYSIASSAIGDFGFGDSKLDFAVSRGIDDIMVDLAAK
What is the function of this protein?
May play a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power.
What are the official names of this protein?
Ferredoxin--NADP reductase, chloroplastic, FNR.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side. Note=In the vicinity of the photosystem I in the non-stacked and fringe portion of the membrane.
Protein: TGT_PSEAE
Sequence: MNFELLATDGKARRGRLTFPRGVVETPAFMPVGTYGTVKGMLPRDIEDIGAQIILGNTFHLWLRPGTEVIQRHGDLHDFMQWKGPILTDSGGFQVFSLGAMRKIKEEGVTFASPVDGAKVFMGPEESMAVQRALGSDIVMIFDECTPYPADHDVAKRSMELSLRWAKRSKIAHGDSPSALFGIVQGGMHEDLRLRSLDGLQEIGFDGLAIGGLSVGEPKEEMIRVLDFLPPQMPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFVDSGVIKIRNSVHKHDDSTLDPTCDCYTCKHFSRAYLHHLDKCGEMLGSMLNTIHNLRHYQRVMAGLREAIQQGTLAAFVDAFYAKRGLPTPPLDA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PURA_METSB
Sequence: MANVVVVGAQWGDEGKGKIVDWLSIEADIVVRFQGGHNAGHTLVIGNQVYKLALLPSGIVRPGKLSVIGNGVVLDPHHLVDEIAKISAQGVTVTPDNLKIADNVTLILALHRELDAHRESASVAGVKIGTTKRGIGPAYEDKVGRRAIRLMDLAEPDSLDEKIDRLLAHHDPLRRGLGLEPVPRAAIRAELEDVAPKVLPYMDAVWDLLETARRDGKRILFEGAQGALLDVDHGTYPFVTSSNTVAANAATGSGLGPKAIGYVLGIAKAYTTRVGGGPFPTELHDETGQRLGDRGHEFGTNTGRRRRCGWFDAVLVRQTVKTSGIDGIALTKLDILDGFEEIKVCVGYLLDGERINRFPASQAAQARVTPIYETMEGWAGTTAGARSWAELPAQAIKYVRRIEELIEAPVALLSTSPQRADTILVHNPFRD
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 6PGD_CHLTR
Sequence: MAPNTDIGLIGLAVMGKNLVLNMVDHGFSVSVYNRSPAKTEEFLKDHGESGALQGFTTIQEFVQSLKRPRKIMIMIKAGAPVDEMIASLLPFLEEGDILIDGGNSYYLDSEQRYVDLKKEGILFVGMGVSGGEEGARKGPSIMPGGNIDAWPAIAPIFQSIAAQVDGRPCCSWIGTGGAGHFVKAVHNGIEYGDIQLICETYEILKTRLNLSLEQIGNIFFEWNQTDLNSYLIGAAAAVLIAKDENGNAIASTILDVAGQKGTGRWVAEDAIKAGVPMSLIIESVLARYLSTWKEVRTKAAQEFPGIPLLCQPPQEASAFIEDVREALYAAKIISYAQGFMLLKQVSQDKGWDLNLGELALIWRGGCIIQSAFLDKIHQGFENSPEAHSLILQDYFKKVLFDSETGFRRAVLHAIGSGVAIPCLSSALSFYDGYRTVDSSLFLVQGLRDYFGAHGYERRDCPRGEFYHTDWLETKKTFRV
What is the function of this protein?
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
What are the official names of this protein?
6-phosphogluconate dehydrogenase, decarboxylating.
What is the protein family that this protein belongs to?
Belongs to the 6-phosphogluconate dehydrogenase family.
Protein: RPOC1_CROS5
Sequence: MKPAQDTRFDYVKIGLASPERVRQWGERTLPNGVVVGEVTKPETINYRTLKPEMDGLFCERIFGPSKDWECWCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGYIKLAAPVTHVWYLKGIPSYMSILLDMALRDVEQIVYFNAYVVLDPGNASNLSYKQLLTEDQWIEIEDQIYAEDSDLYGIEVGIGAEAIQRLLQEMNLEEIAEILREEIAQSKGQKRAKLIKRLRVIDNFIATGSLPAWMVLDVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKIYQCGLPREMAIELFQPFVIHRLIRLGLVNNIKAAKKLIIKGDPSVWNVLEEVITGHPVLLNRAPTLHRLGIQAFEPILVEGRAIQLHPLVCPAFNADFDGDQMAVHVPLSLESQAEARLLMLACHNILSPATGKPIVAPSQDMVLGCYYLTAENPQSQKGNGRYFGNIDDAVKAFEHGLVDLHAYVWLRSEDPNEEVVTDLPDTEVLKTETLEDGSVIKHYRERRVREIDGEAVSQFIRTTPGRIIYNKTIQDALTVA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: PLK4_XENLA
Sequence: MAGSIGERREDFKVLNLLGKGSFACVYRAQSINTGIDVAIKMIDKKAMQKVGMVQRVRNEVEIHCQLKHPSILELYNYFEDSNYVYLILEMCHNGEVNRYLKNRKKPFAEDEARHFMHQIVTGMLYLHSHGILHRDLTLSNLLLSSDMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLESDVWSLGCMLYTFLVGRPPFDTDTVKNTLNKIVLADYEMPDFVSREAKDLIFQLLRKNPADRLSLSSVLDHAFMTGFSNVQSKVMGAVEDSMDSGHATISTGFTGSSGVSISGRFQEKRILSGPSLPNKVNIFQFKDKHPTERSNGGSFHNTQRENNDFSEGNGRKPVACEDRPHSRYLRRAHSSDRSGTSQSQTYAKPSSYSERCHSVEMLAKPTHLKGYRTSSPPNSYGDIPQMFTDERSLERHTSPPVKEKTPSEFMGPAKQTAPRSNDKAETVQQWFGAMQLNGQFKNTPDTSSVSNMGGDFYSQQATQNGAPQYAWNDVKRKKNTDSSIESVLLGIKKNPGTGQRKAEKSQFGEQSKSRVPQQAFGSSTLRSIISPLNAERLKPIRQKTKNAVVSILESGEVCMEFLKEQNSQERVKEVLRISCDGNLIYVYHPNEGKGFPLVDRPPSPPENRLSYTFDSLPEKYWKKYQYAAKFIKLVRSKTPKVTYYTRYAKCMLMENSPTADVEVCFYDGAKIHKTSDVIRVIEKSGRSYTLEGSRLSTLSDEVRSYLDHANESHCVCLSLESAINTEEKKGENISLFPITFGRRPALAESPKTQPTPSVDSARERKEEQSYVNRVLHGSAASPPQMPNLNPSLISYDGSVFSATTVQPSPTSNIHNTPDHAQVLKSVFVENVGWASQLNSGAVWVQFNDGSQLVVQPGVSSIIYTAPNGQITRHGENDKLPEYIKSKLQCLSSILMLFASSSSR
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors.  Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase Sak.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrioles throughout the cell cycle (By similarity). Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles.
Protein: PSAI_NICSY
Sequence: MTNLNLPSIFVPLVGLVFPAIAMASLFLHVQKNKIV
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PEPQ_XANOM
Sequence: MTQPSLNSLYSDHLRTLTARADEALQRGGFAHLVVPSGNTHYQLFDDRDYPYAVNPQFKAWLPLTRVPHSWLVYTPGKRPIVIFYQPFDYWHVVPDAPSGWWVEHCDIHIIRRPDEALALLPKQAERCAILGEAQSTLGAYVPNNPQPVLDYLEYQRAFKTAYELALLRIAQQLAVRGHRAAEAAFRAGQSEFGIHMAYCAAVGQDANELPYGNIIALNEHGAVLHYTELGQQPPQPLRSFLIDAGASAYGYASDITRTYAADPGSDFQALINAVDAAQLRMGQNVRAGVDYKQLHIDAHLALMGILKEFGVLTVSPEAALATGISAAFFPHGLGHLIGLQVHDVAGFAASDRGGRIQRPEGHPYLRLTRVLEPGMVVTIEPGVYFIDMLLDEVKKNGHAASVNWQRVEAFKPYGGIRIEDEVVCTDGNAENLTRPVFAAA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: DCD_PYRAE
Sequence: MILANDELKKLISTGRLKVDPLYPDTIRENGLDLRIGGEYAIYAYEGVVIKPCELESARHLFRVVKADEVVIPPRNFALLTTEEYVKMPDDVVGFANLRSTLARYGLVIPPTIVDAGFEGNITIEVVNETPNTIVLRRGMRFLHLVLAKTEGRAQYSGLYQGQRGVTPPKGLKNEC
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: ELP4_MOUSE
Sequence: MAAADTCGAGTLSSRSVASEAGQGGTSSFQRKGKASGGPGGGPRLLSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTLLLIEEDKYNIYSPLLFKYFMAEGIINGHTLLVASAKENPAKILQELPAPLLDDNSKKELEDVHSAKTPEPNVNMKIAWRYQLQPKMEVGPVSSSRFGHYYDLSKRIPWELLQSSKWHGFFLPEHISPDLKGESCFLSCGYMRLLEFIQKSVYAEGFDGANPQKKQKNILRIGIQNLGSPLWGDDICCKENCDNNHRLTKFLYILRGLLRSSLSACIITMPAHLVQNKSITTRVRNLSDTVVGLESFIGSERETNPLYKDYHGLIHIRKIPRLNNLTCDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVGRSSKQDLAASTARLGAGCSSMAEGKKHLDF
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).  The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
What are the official names of this protein?
Elongator complex protein 4, PAX6 neighbor gene protein.
What is the protein family that this protein belongs to?
Belongs to the ELP4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SSDH_HYLLA
Sequence: MATCFWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGGLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCSWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIYTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGALASKFRNTGQTCVCSNRFLVQRGIHDAFVKAFAEAMKKNLHVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATIVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
What is the function of this protein?
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
What are the official names of this protein?
Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PSD_BRUO2
Sequence: MSLTDTIRNTFVPIHREGYPFIAGFFVVSLILGWLWDPLFWIGMVLTVWCIYFYRDPERVTPMDDDLVISPADGKVSFVGLAVPPAELDLGYEPMTRVSVFMNVFSVHINRSPVRGKIDKVVHRPGKFLNAELDKASTENERNSVLIESPHGKVGVVQIAGLVARRIVCWSNQDDELSVGERFGLIRFGSRVDVYLPSDATVRVAVGQTAIAGETVLADYGTERGEPVVRIA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HFT_BPCA1
Sequence: MKTLRTLKISPNAPDINSVWLYKGTMKYFNNGEWETIGGESEPYVLPAATTSTIGGVKKATNVGNLATGAELATVVTKVNAILSALKVADIMVEDAN
What is the function of this protein?
Forms short fibers at the surface of the viral capsid.
What are the official names of this protein?
Head fiber trimeric protein, Capsid fiber trimeric protein, Gene product 21, gp21.
Protein: MTLD_ECO8A
Sequence: MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVNAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAILDEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYSLPHKNLIQGIAGAMHFRSEDDPQAQELAALIADKGPQAALAQISGLDANSEVVSEAVTAYKAMQ
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.