PharMolix/UniProtQA huggingface dataset:
Protein: SYL_HAEDU
Sequence: MQQQYNPSAIESKVQHFWEENKVFKAVKDITKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVISRYQRMIGKNVLQPMGWDAFGLPAEGAAVKNNTAPAKWTYENIEYMKNQLKVLGFSYDWDREITTCRPEYYKWEQWFFTELYKKGLVYKKTSTVNWCPNDETVLANEQVHEGCCWRCDTPVEQRDIPQWFIKITDYAEELLTQLDNLTQWPDQVKTMQRNWIGRSEGVEITFKIAGSNATLPVYTTRPDTFFGVSYLAVAAAHPLAELASTNNPALAEFIREAKNTKVAEAELATMEKKGMPTGLFAIHPLTGKEIPVWVANFVLMHYGTGAVMAVPAHDERDFDFAKKYGLQINQVIQPLDASTWDFSQAAFTEHGKLINSAEFDGLDFNHAFNAIADKLESLGVGKRQVNFRLRDWGVSRQRYWGAPIPMMTTEQGEVVTVPLKDLPVILPENVVMDGVQSPIKSDPEWAKTTYEGQPALKETDTFDTFMESSWYYARYTCPQYHQGMLDADEANYWLPVDQYIGGIEHATMHLLYFRFFHKLLRDAGILTSDEPATKLLCQGMVLADAFYYTSPTNERIWVSPTQVSLERDEKGRIINATDPAGHKLVHSGMTKMSKSKNNGIDPQEMVEKYGADTVRLFMMFASPAEMTLEWQESGVEGAKRFLGRVWNLVYEYVQQPATQALNALELNKAQKELRRDVHKTIAKVSDDIGRRQTFNTAIAAIMELMNKLNKAPLESDQDKAVMAEALSAVVRMLYPITPHICFELWQALGNQQTIDFAPWVVSDETAMIEDEKLVVVQVNGKVRGKITVPANASEDEVKITAKNDANVAKFLADMQIVKEIYIPFKMLNFVVKV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AURS_GIBZE
Sequence: MSKQKPSLWRALRALSFIISIPLLIQYLVLKWYSTSQNTPTPVFHEPNHETNLTVWEVLSNDDRVSKFVDVIGKLPDIVRGLSAPQARFTVYAPVNEAFDSFYFPPDPPPFFGLFIAGCHMGPGPVPAERLPSMGTVSSFVNGDIFFTYKQRISVQKDKSGLTLNRAARVLPVNASQSIAVNGFVHHIDTVLELPNSTAHALRTRPELSKLRRGLEATKLSESIYDTNAHVSQTIFAPTNAAFDRLGKTATKFLFSHGGRPYLRALLKYHVVANKTLFSDSYWPHGGAKLMDLSLIPNKDSHQFDLPTLHNNLTLQVESRKIHKKWHLNVLKDQVAEGKSHDSIPVSMPDVILMDGVMHFIDSILLPPAKSEQRKTSWLSRLKSSLGHNKQSIEDLVTLLGPYIDEP
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655).  The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488).  The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881).  The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488).  Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488).  Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
What are the official names of this protein?
Aurofusarin biosynthesis cluster protein S, Gibberella pigment protein 9.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space.
Protein: CINAL_PROMM
Sequence: MPIAMVMAEASARHGVEILCIGTELLLGNILNSNARWLAEELAALGLPHYRQTVVGDNVERLKESVLEAVDRSRILITTGGLGPTPDDLTTETLAAAFDTPLEERPELWFEIQAKLTAGGSISAISNRKQALFPRGAEILPNPSGTAPGMIWCPRPGFTVLTFPGVPSEMKQMWSQTAVPWLRQHGGLADIFVSRLLRFTGIAESTLAEEVADLLEQGNPTVAPYAGLGEVKLRITARGATVEQARQLLDPVDAALRHRTGLFCYGSDDESLASVVLDLLRQRGETVVVAESCTGGGVGAALAAVPRASEVFLGGVIAYSNAIKQALLGISTDLLHQHGAVSDPVVRAMAEGARQRLGADWSIAVSGVAGPGGGTHAKPVGLVHIAVAGPHGCDASPVQFGVRRGRLAIQELSVVRSLDQLRRLLLDGS
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: CKB21_ORYSJ
Sequence: MAALHHQAAAAPVTTTTDGGELRAMDLYEKLEKVGEGTYGKVYKAREKATGRIVALKKTRLPEDDEGVPPTALREVSLLRMLSQDSHVVRLLDLKQGQNKEGQTILYLVFEYMDTDLKKFIRAHRQNLQKIPVPTVKILMYQLCKGVAFCHGRGVLHRDLKPHNLLMDRKTMALKIADLGLSRSFTVPLKKYTHEILTLWYRAPEVLLGAAHYSTPVDIWSVGCIFAELATNQPLFAGDSEVQQLLHIFKLLGTPNEQVWPGVSKLPNWHEYPQWNPSKVSDLVHGLDADALDLLEKMLQYEPSKRISAKKAMEHPYFNDVNKELY
What is the function of this protein?
Forms a complex with CYCB2-1 or CYCB2-2 that activates CDK kinase in tobacco BY2 cells during G2/M (mitosis) phases.  May be involved in the regulation of the cell cycle at the G2/M transition.
What are the official names of this protein?
Cyclin-dependent kinase B2-1, CDKB2;1, CDKB;2, CDC2Os-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, phragmoplast. Note=Associated to mitotic spindle during metaphase, and progressively localized the phragmoplast during telophase.
Protein: GRAN_GVXN
Sequence: MGYNKSLRYSRHNGTTCVIDNKHLKSLGSVLGDVRHKEELIREAQFDPIKDIANQYMVTEDPFRGPGKNVKITLFKEIRRIQPDTMKLVCNWSGKEFLRETWTRFISEEFPITTDQEIMDLWFELQLRPMQPNRCYKFTMQYALAANPDYVAHDVIRQHDPYYVGPDNRERINLSKRGLAFPLTCLQSIYNENFEEFFDQVLWPYFHRPLVYVGTTSAEIEEVMIEVALLFKIKEFAPDVPLFTGPAY
What is the function of this protein?
Component of the virus occlusion bodies, which are large proteinaceous structures, that protect the virus from the outside environment for extended periods until they are ingested by insect larvae.
What are the official names of this protein?
Granulin, Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the polyhedrin family.
Protein: CDX1_XENTR
Sequence: MYVGYLLDKDNNMYPNPVRHPGLNLNPQNYVPAPPQYSDFPSYHHVPGINSDPHHGQPGGTWSSYTPSREDWHPYGPGPGASSANPAQISFSPSDYNPVQPPGPGLLPPSLNSSVSPLSPSAQRRNLYEWMRRTGVPTSTNSNGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAASLALTERQVKIWFQNRRAKERKVNKKKMQQQSQQASTTTPTPPSVGTTAGMGGLCSSSSSNSNLVSPSSMPIKEEYLS
What is the function of this protein?
Plays a role in transcriptional regulation.  Involved in activated KRAS-mediated transcriptional activation of PRKD1.  Binds to the PRKD1 promoter.  Could play a role in the terminal differentiation of the intestine.  Binds preferentially to methylated DNA.
What are the official names of this protein?
Homeobox protein CDX-1.
What is the protein family that this protein belongs to?
Belongs to the Caudal homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RRAB_ACTSZ
Sequence: MTHATPQELQAETREIIENLLNDGSDPNALYIIEHHIAHYDFDKLEKIAVDAFKAGYEVSDAEELEDDNGKPLYCFDIVAEVELKAEIIDAQQQQLVPLVAKHGGIYDGWGTYFEDPNADEDEYGEDGEFFDDEFADDDEKR
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity B.
What is the protein family that this protein belongs to?
Belongs to the RraB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_HALSA
Sequence: MAIGLNVTEPEGTCSDEDCPFHGNLSVRGQVLEGEVASTDMEKTVVVEREYDVFVPKYDRYMKRRSRVPAHAPECFDISVGDTVSIAETRPLSKTKSHVVVEITDGGDA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17, HHAS17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: COPA_HELPJ
Sequence: MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFNENETNLDEIFKLIEKLGYSPKKTLAEEKKEFFSPNVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLTINHHSNFLNACLQLIGALIVMHLGRDFYIQGFKALWHRQPNMSSLIAIGTSAALISSLWQLYLVYTNHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMHNNQQIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGTLNSNTSFLMKATQDNKNSTLSQIIEMIHNAQSSKAEISRLADKVSSVFVPSVIAIAVLAFVVWLIIAPKPDFWWNFRTALEVFVSVLVISCPCALGLATPMSILVANQKASSLGLFFKDAKSLEKARLVNTIVFDKTGTLTNGKPVVKSIHSNIELLELLSLASSIEKSSEHVIAKGIVEYAKERNAPLKDISEVKVKTGFGISAKVDYQGAKEIIKVGNSEFFNPINTLEIKENGILVFVGRAINEKEDELLGAFVLEDLPKKGVKEHIAQIKNLGINTFLLSGDNRENVKKCALELGIDGYISNAKPQDKLNKIKELKEKGRIVMMVGDGLNDAPSLAMSDVAVVMAKGSDVSVQAADIVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANIMLSPAIAGLAMSLSSVSVVLNSQRLRNFKIKDH
What is the function of this protein?
Probably involved in copper export.
What are the official names of this protein?
Copper-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BAMA_KLEP3
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRPGDTVTDDDISNTIRALFATGNFEDVRVLRDGDTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTIADIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAKIQQINIVGNHAFSTDELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYITVNITEGDQYKISGVQVTGDLAGHSAEIEALTKVEPGELYNGAKVTKMENDIKKLLGRYGYAYPRVQSQPEINDSDKTVKLHVNVDAGNRYYVRKIRFEGNDTSKDAVLRREMRQMEGAWLGSDLVDQGKDRLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYAVGINGTKNDYQTYTELSVTNPYFTVDGVSLGGRIFYNDFDANDADLSDYTNKSYGTDVTLGFPVNEYNTLRAGVGYVHNSLSNMQPQVAMWRYLNSMGQYPDNTNDRNSFSANDFTFNYGWTYNKLDRGFFPTEGSRVNLNGKVTIPGSDNEYYKATLDTATYVPIDNDHQWVVLGRTRFGYGDGIGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYFPSSSRHDGDSGYTNDCKSTESAPCKSDDAVGGNAMAVASLELITPTPFISDKYANSVRTSVFWDMGTVWDTHWDSNAYGGYPDYSDPSNIRMSAGIAVQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: TBX10_MOUSE
Sequence: MAVFLSAGLGVLAPPETCPHPETSTSWESRLGTRFPSGSCTMSTEAQAMAEPTGQGPKNPRVSSVMVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPTFQVKILGMDTLADYALLMDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLTNNLMDDNGHIILNSMHRYQPRFHVVFVDPRKDSARYAQENFKSFVFTETQFTAVTAYQNHRITQLKIASNPFAKGFREADPDSWPVTPRPLLSIPARSRSSLSPCLLKGSAEREKDTSKASASSSRTPTQPHNQLLPAPDVLLAPATYRPLPYQNLYPGSPSRAGPPRARLAPYPLPNISTAGDQEDPTLAAGLGLLPTSALCLVSNQASQ
What is the function of this protein?
Probable transcriptional regulator involved in developmental processes.
What are the official names of this protein?
T-box transcription factor TBX10, T-box protein 10, MmTBX7, T-box protein 13.
What are the subcellular locations of this protein?
Nucleus.
Protein: YME2_ASHGO
Sequence: MMFLEMQRAFMLHGRRAVTRSAVGVRYISEDIQQKDAQAGEKATATATGVIYKSDEETLMYFDNVYPRATSLWRPTQWYNILLSNQSREAVREKIMRLASPASNPVHGLELRSTIPIKRDGGVFATFRVPREYTRAQVNALIQANTQQESSKSLLAAFTRAAAFPVKGVPWIEDLKRLPNNVVRVEVEGPALSEEELYSLFRRYGTILDIYPAGKNGYATIRYRSFRGAICAKNCVSGIEINGSTLHVKFEPVVRAHAIRDFFVNHPRIAIPLLIALLSICAVLIFDPIREFSIEQKITRMYTLSRDNFVVKSILRLTSYTVSSVKHLWGYDDDQPEKRQLWQERVEKVNDLKMWLEENNNTFVVVTGPRGSGKHELVMQHTLHDRPNVLYLDCDTLIKSRTDSKFLRNAAHQIGYFPIFPWLNSVTTLVDLAVQGLTGQKSGLSESKETQFRNMLNTAMMSIRHIALSGYKATLHSGDDVTTVKEEDYLQQHPERKPVIVIDRFSNKAEINGFVYKELADWASMLVQMNIAHVIFLTESVSPNQLLAEALPNQVFKFLFLSDASKDSARSYVLSQLYPSSPAYSEKMPAADADANEEYRKEIDRALEPIGGRMLDLQAFVRRVKSGEEPSEALEKMVEQASEQITQIFLSERSEPIKTAQAWELIELLSQNDVVKYGDIVFRPLFKSSPEAGLLELEKNGLITISRNRGVLQDIRPAKPLFKAAFSYLLQDKDLSIVLRTGYYLRLIAFETGRIKKWEEELRLLAKVSDQRICKSRLNYLASKIDASSGVINSCEDKVKEMSKRI
What is the function of this protein?
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape.  Involved in the regulation of mtDNA nucleotide structure and number.  May have a dispensable role in early maturation of pre-rRNA (By similarity).
What are the official names of this protein?
Mitochondrial escape protein 2.
What is the protein family that this protein belongs to?
Belongs to the YME2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: H13H1_CYRHA
Sequence: MKTAIFTVVLALAVFAVLSFGWEANEKALSEEFTELIHEKEAASETEARGCRYFWGECHDHMPCCDWLVCRYKWPITYNICVWNRTFPEK
What is the function of this protein?
Ion channel inhibitor.
What are the official names of this protein?
U7-theraphotoxin-Hhn1f, U7-TRTX-Hhn1f, Hainantoxin-XIII-8, HNTX-XIII-8.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 13 (Hntx-13) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MTNB_LEPBP
Sequence: MDLITSLQEITKLSHLYYERQWMYATAGNLSTRDGSSRDQFWITASGKHKGELKDTDFVCVSVADGTLLKASDGLKPSAETSIHQVLYSQMPDIGCCLHVHTIDSNLLEFGVGKEEGSREIPIPPIEIIKAFGIWDEKPNLTMPVFYNHTHVPTIADEIKRYFISVGIPKVPFLLIEGHGPTVWGKSIAEANKHLEAVHFLLQVMARKV
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: EF2KT_BOVIN
Sequence: MAPEERADAARLLRGFERRFLAARALRSFPWQSLEEKLRDSSGSELLLDILQKTVKHPLCVKHPPSVKYSRSFLSELIRKHEAVHTEPLDELYQALAEVLTAEDPTHCHRSYLLPSGDSVTLCESTAIVSHGTTGLVTWNAALYLAEWAVENPAVFAHRMVLELGSGAGLTGLAICKTCRPRAYIFSDCHSHVLEQLRGNVLLNGFSLEPSIDTWAQHPGPHTPEAERPWVTVARLDWDTVTAPQLAAFQPDVVLAADVLYCPETVLSLVGVLRKLSTCRKDQRAPDAYIAFTVRNPETCQLFTTELGQAGIPWEEVPCHDQKLFPYEEHSEMAILKLTL
What is the function of this protein?
Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.
What are the official names of this protein?
Protein-lysine N-methyltransferase EEF2KMT, eEF2-lysine methyltransferase, eEF2-KMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPA2_YEAST
Sequence: MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGLLNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERKVYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYELVQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVRPDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDSFLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLVHLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEYLQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQGKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDKEDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTGYDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKLDEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQTVSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTIGMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGEELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALIGHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKKLLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNVEPK
What is the function of this protein?
DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors.  Besides, RNA polymerase I has intrinsic RNA cleavage activity.  RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center.  In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I.  A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I.  A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
What are the official names of this protein?
DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I 135 kDa polypeptide, A135, DNA-directed RNA polymerase I polypeptide 2, RNA polymerase I subunit 2.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RT65_MYXXA
Sequence: MSWFDTTLSRLKGLFSRPVTRSTTGLDVPLDAHGRPQDVVTETVSTSGPLKPGHLRQVRRDARLLPKGVRRYTPGRKKWMEAAEARRLFSATLRTRNRNLRDLLPDEAQLARYGLPVWRTEEDVAAALGVSVGVLRHYSIHRPRERVRHYVTFAVPKRSGGVRLLHAPKRRLKALQRRMLALLVSKLPVSPQAHGFVPGRSIKTGAAPHVGRRVVLKLDLKDFFPSVTFARVRGLLIALGYGYPVAATLAVLMTESERQPVELEGILFHVPVGPRVCVQGAPTSPALCNAVLLRLDRRLAGLARRYGYTYTRYADDLTFSGDDVTALERVRALAARYVQEEGFEVNREKTRVQRRGGAQRVTGVTVNTTLGLSREERPRLRAMLHQEARSEDVEAHRAHLDGLLAYVKMLNPEQAERLARRRKPRGT
What is the function of this protein?
Reverse transcriptase (RT) responsible for synthesis of msDNA-Mx65 (a branched molecule with RNA linked by a 2',5'-phosphodiester bond to ssDNA).  The retron transcript serves as primer (from a conserved internal G residue) and template for the reaction, and codes for the RT (By similarity).  The retron is involved in antiviral defense (By similarity).
What are the official names of this protein?
Retron Mx65 reverse transcriptase, Mx65-RT, RNA-directed DNA polymerase from retron Mx65.
What is the protein family that this protein belongs to?
Belongs to the bacterial reverse transcriptase family.
Protein: PTH_EHRCR
Sequence: MFYLLAGLGNPGKKYELSRHNAGFMIVDAIASEFYFPSFRERHNALISIGNIKSHRVILVKPWTFMNNSGAPIMSIASLYKIPLDNIIIFHDEVEINFCTIRVKKSGGNAGHNGLKSIDNLLGKDYWRVRFGIGRPINKTNLKIDLSYYVLSQFHNIKAVNNTILNIVEHITLLLEKKPSMFMEKVKNLIKYEDIPTE
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_RUEST
Sequence: MLYWLTALSDGGDFFNLFRYITFRAGGAFLTALIFGFVFGKPLINVLRKRQGKGQPIRDDGPEAHLAKVGTPTMGGLLIVGALLFSTLMWARWDNPFVWLVLFVTMSFGLIGFADDYAKVSKQNTSGVSGKVRLLLGFVIAIVAALWASWNHPAELQNQLAMPVFKDVLLNLGYLYVPFCICVIVGAANAVNLTDGLDGLAIMPVMIAAGTLGIIAYAVGRVDFSEYLDVHYVPGTGEILIFTSALFGGGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAISTKHELVLAIVGGLFVVEALSVIIQVLYFKRTGRRVFLMAPIHHHYEKKGWAEPTIVIRFWIISLILAMIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRM1_METBU
Sequence: MLSTKVTEGSTTVSVPVPPEGVPFPPSEAPVFYNPHMELNRDISVAATSACAKRILLKKDMELKDITYLDAMSASGIRGLRIANEVGITSILNDWSDDAYGLILENIGLTGVSDIAEATCKNANVLMHERRFNIVDLDPFGSPTPYLDAATRSAVHFLEVTATDTAPLCGAHFNSGMRKYAAVPLNNEFHSEMGVRILLGKIARELAKHDKGMTPLLSHATRHYVRTYLQVKKGAKLADKAFKDLGFLSHCEHCGHREIFHGMAISISDHCSSCGNDVYIAGPLWLGQLHEPQYCDEVLLELEDRSLGTKEQAKKLILACRDELDIPFFYDQHVICKMIGVSAPAMDMFIAALRETGANVSRTHFTGISFKTDAKIDTIKDVLRSL
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: FDHD_NOCFA
Sequence: MSGRVTARRRVVRLTPAGEIRRQDTLAVEEPLEIRIGGQSLTVTMRTPGSDIDLVHGFLLSENMIGAAEDVVSARYCAGTDEQGRNTYNVLDVELRRPVPVRTRHVLTTGACGLCGKTALDEVRAVTRFPLPAHGVTLAADVLADLPATLRAGQSVFQATGGLHAAGLFTVDGTPLAVREDIGRHNAVDKVIGWALRENRVPAHELVLIVSGRASFELVQKAVMAGIPILGAVSAPSSLAVDLAEEAGLTLVGFLRGETMNVYSGAHRLRSVSAGTRTA
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHB7_ARATH
Sequence: MNVKKVPNVPGSPALSALLKLGVIGGLGLYCIGSSMYNVDGGHRAIVFNRFTGIKDRVYPEGTHFKIPLFERAIIYDVRSRPYVENSQTGSNDLQTVTIGLRVLTRPMGDRLPEIYRTLGQNYGERVLPSIINETLKAVVAQYNASHLITQREAVSREIRKIVTERAAKFNIALDDVSITNLKFGKEFTEAIEKKQVAAQEAERAKFIVEKAEQDKKSAIIRAQGEAKSAQLIGQAIANNEAFITLRKIEAAREIAQTIAKSANKVYLNSSDLLISKQ
What is the function of this protein?
Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
What are the official names of this protein?
Prohibitin-7, mitochondrial, Atphb7.
What is the protein family that this protein belongs to?
Belongs to the prohibitin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein.
Protein: PDI2_SCHPO
Sequence: MRLPLLSFVIFALFALVFASGVVELQSLNELENTIRASKKGALIEFYATWCGHCKSLAPVYEELGALFEDHNDVLIGKIDADTHSDVADKYHITGFPTLIWFPPDGSEPVQYSNARDVDSLTQFVSEKTGIKKRKIVLPSNVVELDSLNFDKVVMDDKKDVLVEFYADWCGYCKRLAPTYETLGKVFKNEPNVEIVKINADVFADIGRLHEVASFPTIKFFPKDDKDKPELYEGDRSLESLIEYINKKSGTQRSPDGTLLSTAGRIPTFDEFAAEFLDMSNAAKEVVLEKVKQLALEDSSRWTKYYKKVFEKILNDENWVHKEAKRLSKLLRQKSIALASADDFKTRLNILNSFLPGNH
What is the function of this protein?
Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.
What are the official names of this protein?
Protein disulfide-isomerase C17H9.14c.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
Protein: DHSC_SALTY
Sequence: MIRNVKKQRPVNLDLQTIRFPITAIASILHRVSGVITFIAVGILLWLLGTSLSSPEGFQQAADIMDGFIVKFIMWGILTALAYHVIVGIRHMLMDFGYLEETFEAGQRSAKISFVITVVLSLLAGVLVW
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase cytochrome b556 subunit, Cytochrome b-556.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b560 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: T2S1_SALIN
Sequence: MSEAVFFVENAEELAKQKMDNINPELSEKFQLLIKFLSRFPESCSNPRSKQVRKNFGKAEHIEYLAQNFNESRLPKKPTPPTTIPDEVVSLVLNVSFDIPQENLNRIKEEHRLSMASENIVGDLLERYLAEKLEPCGWIWCSGTSVKAVDFIHYDNEKDEWGLLQVKNRDNTENSSSSKIRDNTPIKKWFRTFSQRDATNWENFPDEVSSKDLNEDDFRAFVESYLRKIK
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GGWCC-3' and cleaves after G-1.
What are the official names of this protein?
Type II restriction enzyme SinI, R.SinI, Endonuclease SinI, Type-2 restriction enzyme SinI.
Protein: YAGJ_ECOLI
Sequence: MEARVTVAGMGLVMEVQDYFDGEADRLAKAWLAEYTPQIKSLKDERKEAYRQIVEMSTEPQDVDLVRPANKFEMTRVREGEKEADLPVWKHHLLCDESGNYPALLNHWETKVFEIETKREGFAFWYRNPQYTGQSSLGIAYVEAEQYKIVRPDFLFFAEQDGKMVVDLVDPHSLHLADALPKLEGLALYAEHHSDAYRRIESVAEVKGKLRVLDLKRQDVQDAVATAENAETLFSSGLADDYQ
What are the official names of this protein?
Protein YagJ.