PharMolix/UniProtQA huggingface dataset:
Protein: EFNB2_MOUSE
Sequence: MAMARSRRDSVWKYCWGLLMVLCRTAISRSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCARPDQDVKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSARNHGPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNLLGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRGGNNNGSEPSDVIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
What is the function of this protein?
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.  Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4.  Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration.  EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.  May play a role in constraining the orientation of longitudinally projecting axons.
What are the official names of this protein?
Ephrin-B2, ELF-2, EPH-related receptor tyrosine kinase ligand 5, LERK-5, HTK ligand, HTK-L.
What is the protein family that this protein belongs to?
Belongs to the ephrin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction.
Protein: NOMO1_MOUSE
Sequence: MRAGRCAAALLLLLLSGAGRAIGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTNVELRVDGVSDICTKGGDINFLFTGFSVNGKVLSKGQPLGPAGVQVSLRSTGADSKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVNKEDVLGCNVSPVSGFQPPDESLVYLCYAVSKEDGSFSFYSLPSGGYTVVPFYRGERITFDVAPSRLDFTVEHDSLRIEPVFHVMGFSVTGRVLNGPDGEGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFEMVTIKIAPNTPQLADLIATGFSICGQIAIVRSPDTIKQMSKYRVVLSSQDKDKALLTVDSDAHGSFCFKAKPGAYKVQVVVPEAETRAGLMLKPQVFPLTVTNRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNSMTFTFDKVLPGRYKISIMHEDWCWRNKSLEVEVLEDDVSAVEFRQTGYMLRCALSHAITLEFHQDGNGPENVGIYNLSRGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTIITDKMMDVTVTIKSSIDSEPALVLGPLKSAQELRREQQLAEIETRRQEREKNGKEEGEEGRARPPGQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVNSQKEGYVLTAVEGTVGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLRITITGFRTAYSCYGTVSSLNGEPEQGVAVEAVGQKDCSIYGEDTVTDEEGKFRLRGLLPGCMYHVQLKAEGNDHIERALPHHRVIEVGNNDVDDVNIIVFRQINQFDLSGNVITSSEYLSTLWVKLYKSESLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDTTLPRSQYDYVLPQVSFTAVGYHKHITLVFSPTRKLPEQDIAQGSYIALPLTLLLLLAGYNHDKLIPLLLQLTSRLQGVRALGQAASDSSGPEDMKRQTKKQKTRRT
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.
What are the official names of this protein?
BOS complex subunit NOMO1, Nodal modulator 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RIPR1_RAT
Sequence: MMSLSVRPQRRLLSARVSRSQSFAGVLGSQERGPRNFTVFSPPGPQRKPLVLSRVSRMFSVAHPAPKVPQPERLDLVYAALKRGLTAYLEVHQQEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCVQRRLRDGAYNMVRAYSTGSPGSREARDSLAEATRGHREYTESMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEETVFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNKASTVTKRFSTYSQSPPDTPSLREQAFYNMLRRQEELENGTAWSLSSESSDDSSSPQLSGTARYSSTPKPLVQQPEPLPVQVTFRRPESLSSGSMDEEPPLTPALVNGHAPYSRTLSHISEASVDAALTEAMEAVDLKCPAPGPSPLVYPESTHVEHVSSVPPVADNGRSATSPALSTAGPAPTFIDPASSTQLDLVHKATDSGSSELPSITHTMASSTYSAVSPINSVPGLTSTTVGSTHKPMPSPLTSTGSIPSVTDSIQTTTSPTHTTPSPTHTTVSPTHSTPSPTHTTVSPSNAALSPSNATPSLSHSTTSPTQKATMSTHTTSAVGPVQTTTSPISTTVSPSPSVDTAIISSSSAVPSVPGPEARPCSHPTSTPYTKADPTAACTSSPSLASSGPKPLTSPAPDSLEQILKSPSSSPSSIVPEPQRSELSLALVAQAPVPEATGGAGDRRLEEALRTLMAALDDYRGQFPELQGLEQEVTRLESLLMQRQGLTRSRASSLSITVEHALESFSFLNDDEDEDNDSPGDRPTSSPEVVAEERLDSSNAQCLSTGCSALDATLVQHLYHCSCLLLKLGTFGPLRCQEAWALERLLREARVLQEVCEHSKLWGNAVTSAQEVVQFSASRPGFLTFWDQCTEGLNPFLCPVEQVLLTFCSQYGARLSLRQPGLAEAVCVKFLEDALGQKLPRRPHSGPGEQLTIFQFWSYVEVLDSPSMEAYVTETAEEVLLVQNLNSDDQAVVLKALRLAPEGRLRKDGLRALSSLLVHGNSKVMAAVSTQLRSLSLGPVFRERALLCFLDQLEDEDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEEGQSAHRQLEESLDALPCLFGPSSMASTAF
What is the function of this protein?
Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration.  Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation.  Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation.
What are the official names of this protein?
Rho family-interacting cell polarization regulator 1.
What is the protein family that this protein belongs to?
Belongs to the RIPOR family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus. Note=Localizes to the podocyte major processes and cell body. Colocalized with STK26 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with STK26 upon serum stimulation in a Rho- and PDCD10-dependent manner.
Protein: RS13_MYCS2
Sequence: MARLVGVDLPRDKRMEIALTYIYGIGRTRSNEILAATGIDKNMRTKDLTDDQVTVLRDYIEGNLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGLPVRGQRTKTNARTRKGPKRTIAGKKKAR
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MTNK_BACCQ
Sequence: MGYYSLTEVTAVQYAKEHGYFEKKANVVCHEIGDGNLNYVFKLDDGEKSIIIKQALPYAKVVGESWPLSIKRATIESKALQIFAKYVPEYVPVVYSHDEELAVTIIEDLSKLTITRKGLIDGEEYPLLSQHIGRFLANVLFYTSDFGLQSEEKRVLEGTFVNPDLCKITEDLVFTDPFGHYDTNDYESELQLAVDELWSDKTLKLKVAQYKYKFLTRKEALIHGDLHTGSIFSSPSETKVIDPEFATYGPFGFDIGQFIANLLLNALSREEEQRSVLFFHIEKTWSYFVDTFTKLWIGEGVEAYTKEKQWLPIILQNIFTDVVGFAGCELIRRTIGLAHVADLDEIANKETRIQAKKQALSLGRELIKYESKNADIQLFRALFQQTVSGGVKA
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: LAT3A_LACTA
Sequence: MKTYAVLLALVVAFVCIAESTGYPVEDLEDDELTELEAEALLEDLLEDLELEDLDYNEEARSWKSMAKKLKEYMEKLKQRAG
What is the function of this protein?
It has antimicrobial activity against Gram-positive bacteria (A. globiformis VKM Ac-1112 (MIC=0. 3 uM), and B. subtilis VKM B-501 (MIC=1. 2 uM)), Gram-negative bacteria (E. coli DH5-alpha (MIC=2. 5 uM), E. coli MH1 (MIC=6. 0 uM), and P. aeruginosa PAO1 (MIC>40 uM)), and yeasts (P. pastoris GS115 (MIC=20 uM), and S. cerevisiae Y190 (MIC=20 uM)).  Causes paralysis, but is not lethal when injected into insect (M. domestica) larvae (PubMed:16735513).  A second study reports antibacterial activity against E. coli (MIC=100 uM) and S. aureus (MIC=84 uM).  Furthermore, increases efficacy of antibiotics (chloramphenicol, streptomycin, kanamycin, novobiocin) when tested against E. coli, probably by facilitating their incorporation into the bacteria (PubMed:23093034).
What are the official names of this protein?
M-zodatoxin-Lt3a, M-ZDTX-Lt3a, La47, Latarcin-3a, Ltc-3a.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 03 (latarcin) family. 03 subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: Y1579_METJA
Sequence: MNQRKEIELLMFDVLPYMANMEFIKELLESVNSLEELEQKVRELLEKETDITKKTDLKILLEKIEERKNK
What are the official names of this protein?
Uncharacterized protein MJ1579.
Protein: PHS_PROMP
Sequence: MKPYLLEHEELKELSAKIGGWRIMTNHIEREFNFSNFVEAFSFMTKIALICEKHNHHPNWENVYSKVIIKLSTHDLGGITNLDQTIASEINDIFEK
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: GPMA_BIFLD
Sequence: MTYKLVLLRHGQSAWNKTNQFTGWVDVPLTEQGEAEAKRGGELLKEKNVLPDIVFTSLLRRAINTANIALDAADRLWIPVQRDWRLNERHYGALQGKNKTEIREEYGDEKFMLWRRSYATPPPEIDPNDQYAQNNDPRYAGDPVPEAECLANVVERVKPYFESAIEPELKAGKTVLIAAHGNSLRAIVKMLDNLSEEEIAKVNIPTAIPLLYELDENFKPIKPRGEYLDPEAAAAGAAAVAAQGQK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: EAF1_NEUCR
Sequence: MTEVGPADRRKLLHSKRAEANSIVTSRKRKLRELYAVATDEDGFPNHDLNDLDTRPASPGEAKFLFDCEILQGRRLAERLLPVFQRPRFDTLQHIATADESSLGHGPHVVQQVQPSPLIHPNHTIPKNVQHNGLPSPAPPASSIRHEPERTVPYNQVPNGAAGPQEALKAFAPRQEFQKLAPVQGSAVKTADGPSGESKPPAKETPVLLAPAAPHGNGRWNGIINNAPQGRVLPTPQTVAPPATAPTSTTKTANLGEGRAGPKDDTVSRGDAEEKARPKPTITSVNQLLSNGDSIRYPDTLSSPSSTVQSAPTPLGNEASASTSPDNEASQSFDKPVSRPEQELRRATTDNKGVGQFTGPSVAVPELRPQPQQPGVYANGAPEVPISSAPSVRPAASGAEAQLLQESAATRTSQVIGKAGVAGPHGAHSTGGLQTQHPSAVNGEVRNMMNGDIPGKHVASQASVSTGVAVTKAALPEVAKQGPLPQGPESRNNRADVGPTPMDLDRIPTAQAPKPIPSVHAVQEKAPSQESARQPQPSSTAPSTTPPSAQPAVSLEKTVPGIQINAPPETETETQARTSQSSHPDTESAVADEEGDMPPGLLTHRLKSLSTRLRERRRKSVPTVVFGKQYRKPRFSDDTALIVNKPKPPGHIPSEDYFVTLFIESFARTSSWMKPLEKLLHSAHKTVSTSDQTLSILDHQACKILRRVYHLQQHDKWSLRQPVRCLEPARPASHQDLLIKEMKWMRTDFREERKWKRAVARNLAYACAEWYYSSPADRKLLQVDAKIPPVRAVDNADTSMADAPETGESLVPELDHSDSPVGNDEEVPELPITTIAPATIFALQDDEVVFELQPSRTADLLLENLPMYGSPLKVPKFDWIIPDYDPDAKWKRPAVPLSKYVEGEMVLDVKPQPQKRSRFQFQGEDEEEEEEYVFGAQPDKGAKLPPTSTDVALFAPEMKLTRDRLHAGHQFRPPSEHPMPVQSFFESRIASQWTLAEDDQLRALVREYSYNWSLISSMISSRSSFPSAVERRTPWECFERWVNLEGLPSDFAKTPYFKAYQARIDAAGRTILQHNQNAAQGQQVGPNGAVAPIPRKRPTNTMRVERRRNQKHLALFDAMRKLAKKREAAAQKQQAQATMTAMRKTNEQQRQQPQQQLHLQAKTPQEYSLMRAARDQQIAEKMAHLAARQHEIIQKRLLTQRQAQLAATPGVAQVPQTAAQLAAANSLNNAAARLNIPGQMAVTAQKLAPGRVPMQAPAGIPTVPAQLAASGLVPPLPVAAIPQAQLQAMQAQHRLPMVNPTPDINLVMQARRIQDQQRAVAVQLQQQQHQQHQHQQHPQQPQQQGQVQQQVVSQQQQQQHQPQQQQQPQQQQQLQQQQPQQQQPQHQQVQTPQPAQQQPQQPQVTQQPPPVPQVQINGVQGSPTPMRPVVNSLNNGVYMSSVSAQAMMASFNAANSVAGMVTSPGAGLSMPMLPAGSPRGPQIPAQQLPYTHIHTRLKEFETHFRNKNPGATQDQIRQMATEHLGRLIVQTQQHAMNAAAGGVGHSLGTVATTTSPHQYAQLLRAQQQAQAQQAQAQQQAPQPAQSQLTPAQLAQAQAAAAQKQKQAAAAAAQAKVLAQAQMQTQTPAHQPHQPQAQPHVQAQAMAAAQLQAQVQLQAQAAAQKQAAQAHPQAQSQGQGQPPQQTQRAHQVQQVQGQQAHQLPQGSQSQQIQQQVQQSPQARQQSQQPQMVRQPVQQAQQPQQLQQPQQSQKTPQMQPQQQVQTPHQQAQKAQQSQQAQLAQQQQHQQQQQQQQHGQAQSQGQIQGQGQAPGQGQAPGQGHAQGQVQGQVQGQVQGQVQGQVQGQVQGQVQGQAPGQVQPQHAQHSRHTPNSQHAQHTQQAQHARNAQQAHHTQQVQQAQHVQQPQGLQGQRHGQVHGNGQQLHQQHQHQQQQPQQAQQTQQQRQQVHPAPQLPQAQPPQHSHQAQAQHPQTQQAQAPQAQAQQPQPPQQAQAQQVQQPQQAKLTQQAQQAQQAQGQQAQGQQAQGQQAQSQQARAQQAQVQQAQVQQAQVQQAQAQQAQAQQAQAQQAQAQAQAQSHGQMQPQTQPQQQPQPQPQSQPQAHQPQQASQQVQHGLVGQQGQQNRQGQQGQQSHQVQQAQQPQVQQAQQPVATPQSASQTSQNSQPAQQAGMAQQQQGQGSGSAAPAPTK
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Chromatin modification-related protein eaf-1, Esa-1-associated factor 1, Vacuolar import and degradation protein 21.
What is the protein family that this protein belongs to?
Belongs to the EAF1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL23_MARMS
Sequence: MIGERIYKVLLGPHISEKATIVAEGNGQYVFRVTGDATKPEIKQAIEALFEVKVESVRTLNHKGKTKRTVRGLGKRKDVKKAYVRLAEGQDIDFMVAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: XGPT_VIBA3
Sequence: MSNKFVITWDNMQTYCRQLAEKQMPAEQWKGIWAVSRGGLVPGAILARELGIRHVDTICISSYDHDHQRDMTVVKAPEGDGEGFLIVEDLVDSGDTARKLREMYPKAKLIAVCAKPSGADLLDEYIVDIAQDTWIEQPWDTSLSYVEPVNRKSK
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NK3R_CAVPO
Sequence: MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS
What is the function of this protein?
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B).  It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Neuromedin-K receptor, NKR, NK-3 receptor, NK-3R, Neurokinin B receptor, Tachykinin receptor 3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ASER_BACSU
Sequence: MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMSQPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIKQKKTQACCQ
What is the function of this protein?
Metal-responsive transcriptional regulator that represses transcription of the aseR-ydfA operon by binding specifically to its promoter.  Binding of arsenite or antimonite causes the repressor to dissociate from the DNA.
What are the official names of this protein?
HTH-type transcriptional repressor AseR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GOGA1_HUMAN
Sequence: MFAKLKKKIAEETAVAQRPGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGEEHLQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDLEQQLLEKNKTIKQMQQRMLELRKTLQKELKIRPDNELFEVREKPGPEMANMAPSVTNNTDLTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENMLKETLEYKMSWFGSKPAPKGSIRPSISNPRIPWS
What is the function of this protein?
Involved in vesicular trafficking at the Golgi apparatus level.  Involved in endosome-to-Golgi trafficking.
What are the official names of this protein?
Golgin subfamily A member 1, Golgin-97.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane. Cytoplasmic vesicle, secretory vesicle, acrosome.
Protein: LIP_RHIOR
Sequence: MVSFISISQGVSLCLLVSSMMLGSSAVPVSGKSGSSNTAVSASDNAALPPLISSRCAPPSNKGSKSDLQAEPYNMQKNTEWYESHGGNLTSIGKRDDNLVGGMTLDLPSDAPPISLSSSTNSASDGGKVVAATTAQIQEFTKYAGIAATAYCRSVVPGNKWDCVQCQKWVPDGKIITTFTSLLSDTNGYVLRSDKQKTIYLVFRGTNSFRSAITDIVFNFSDYKPVKGAKVHAGFLSSYEQVVNDYFPVVQEQLTAHPTYKVIVTGHSLGGAQALLAGMDLYQREPRLSPKNLSIFTVGGPRVGNPTFAYYVESTGIPFQRTVHKRDIVPHVPPQSFGFLHPGVESWIKSGTSNVQICTSEIETKDCSNSIVPFTSILDHLSYFDINEGSCL
What is the function of this protein?
Hydrolyzes ester bonds of triglycerides as well as of their derived partial glycerides with a strong 1,3-positional specificity.
What are the official names of this protein?
Lipase, RDL, Triacylglycerol lipase, ROL.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: OBG_PSE14
Sequence: MKFVDEVSIRVKAGDGGNGCMSFRREKFIENGGPNGGDGGDGGSIFMVADVNLNTLVDYRYTRHFDAERGSNGGSADCTGRKGEELVLRVPVGTTIIDATTQEIIGDLTKDGQRLMVAQGGWHGLGNTRFKSSTNRAPRQTTPGKPGDQRDLKLELKVLADVGLLGLPNAGKSTFIRSVSAAKPKVADYPFTTLVPNLGVVSVDRWKSFVVADIPGLIEGASDGAGLGIRFLKHLARTRLLLHLVDMAPLDESSAPDAAEVIVNELEKFSPSLAERDRWLVLNKCDQILEEEQEARKQEIVDRLEWTGPVYVISAIAKEGTEQLTRDIMRYLEERSQRIAEEPGYAEELAELDQRIEDEARAQLQALDDQRALRRSGVKSVHDIGDDDWDEEDVDDEDGPEIIYVRD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_SHIBS
Sequence: MATTHLDVCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRTIHQENT
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: DCMS_AFIC5
Sequence: MAKAHIELTINGHPVEALVEPRTLLIHFIREQQNLTGAHIGCDTSHCGACTVDLDGMSVKSCTMFAVQANGASITTIEGMAAPDGTLSALQEGFRMMHGLQCGYCTPGMIMRSHRLLQENPSPTEAEIRFGIGGNLCRCTGYQNIVKAIQYAAAKINGVPFEEAAE
What is the function of this protein?
Catalyzes the oxidation of carbon monoxide to carbon dioxide.
What are the official names of this protein?
Carbon monoxide dehydrogenase small chain, CO dehydrogenase subunit S, CO-DH S.
Protein: RL6_METEP
Sequence: MSRVGKKPVPVPSGVTATVTGQTVKVKGSKGELQFVVPSQVVVEFKDGAVSVQPKDQSKQARSLWGTSRAQVANLVEGVSKGFEKKLEITGVGYRAAMAGKALKLSLGYSHDIEYEIPAGITIVTPKPTEIVVSGIDRQRVGQVAAEIREYRGPEPYKGKGVKYAGEFIFRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL27_RENSM
Sequence: MAHKKGASSTRNGRDSNAQYLGVKRFGGQVVKAGEIIVRQRGTHFHPGAGVGRGKDDTLFALEAGAVEFGARGGRRVVNIVVAAAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: NOL3_HUMAN
Sequence: MGNAQERPSETIDRERKRLVETLQADSGLLLDALLARGVLTGPEYEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRTAGAPDPAWDWQHVGPGYRDRSYDPPCPGHWTPEAPGSGTTCPGLPRASDPDEAGGPEGSEAVQSGTPEEPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEPEPDFEERDESEDS
What is the function of this protein?
Functions as an apoptosis repressor that blocks multiple modes of cell death.  Inhibits extrinsic apoptotic pathways through two different ways.  Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity).  Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity).  Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034).  Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781).  Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity).  Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity).  Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity).  Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity).  Inhibits too myoblast differentiation through caspase inhibition (By similarity).
What are the official names of this protein?
Nucleolar protein 3, Apoptosis repressor with CARD, Muscle-enriched cytoplasmic protein, Myp, Nucleolar protein of 30 kDa, Nop30.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus, nucleolus. Note=The SR-rich C-terminus mediates nuclear localization. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Mitochondrion. Sarcoplasmic reticulum. Membrane; Lipid-anchor. Note=Phosphorylation at Thr-149 results in translocation to mitochondria. Colocalized with mitochondria in response to oxidative stress.