PharMolix/UniProtQA huggingface dataset:
Protein: FABA_SINFN
Sequence: MTTRQSSFSYEEILTCGRGEMFGSGNAQLPLPPMLMFNRITEISETGGPHDKGFVRAEFDITPDLWFFPCHFMGDPVMPGCLGLDAMWQLTGFFLGWLGEPGKGRALSTGEVKFTGMVTPKTKLVEYGIDFKRVMRGRLVLGIADGWMKADGEVIYKATDLRVGLFQEKAD
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GL32_ORYSJ
Sequence: MAKLILATFAVVFLALAATSLAGDPDMLQDVCVADYKSLRGPLRLNGIPCKRLENVTANDFFFDGLTNAGNTTNAVGSLVTAASVERLPGLNTMGVSMARIDYAPWGLSPPHTHPRATEIMFVAEGTLDVGFVTTANKLFTRTVSKGEVFVFPRGLVHFQRNSGNTSALAIAAFNSQLPGTQSIADTLFGAAPPLPSDTLARAFQVDGGMVESIKSKFPPKY
What is the function of this protein?
May play a role in plant defense.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Putative germin-like protein 3-2.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: CH10_PROM0
Sequence: MAAVSLTVSTVKPLGDRIFIKVSASEEKTAGGILLPDSAKEKPQVGEVAQVGPGKLNDDGSRQTPEVSIGDKVLYSKYAGTDIKLGGDEYVLLSEKDILAVVS
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPA_CLONN
Sequence: MTLFKGSGVALVTPFKDGKVNFKKLEEILNWHVECGTDAIIVCGTTGEASTMTEEERKETIKFTVDTINKRIPVIAGTGSNNTEAAIKMSKWAESIGVDGVLVITPYYNKTTQKGIFEHFKAINDSINIPIVLYNVPSRTGLNITPKTLLKLCDLNNVVAIKEASGNFSQLVEMKALCRDKIDLYSGNDDQVVPLLSLGGIGVISVAANIYPKEMHDICDLYMNGKTHEALKIQLDMLDVINSLFIETNPIPIKTAMNLKGMDVGALRLPLCDMEENNLEVLKNALENYNKTSREA
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARFX_ORYSJ
Sequence: MAAAATAAASPVEGLTGGGGGGGGGVDGLFVELWRACAGPLVTVPAVGERVFYLPQGHIEQVEASTNQVAEQQGAPLYNLPWKIPCKVMNVELKAEPDTDEVYAQLTLLPEKQQDGNGSGNGNVSKDKVEEEEVVPPAATERPRVHSFCKTLTASDTSTHGGFSVLRRHADECLPPLDMSQHPPTQELVAKDLHGVEWRFRHIFRGQPRRHLLQSGWSVFVSAKRLVAGDAFIFLRGENGELRVGVRRAMRQQANIPSSVISSHSMHLGVLATAWHAVNTGTMFTVYYKPRTSPSEFVVPRDLYKESLKRNHSIGMRFKMTFEGEEAAEQRFTGTIVGVGDSDPSGWADSKWRSLKVRWDEAASVPRPDRVSPWQIEPANSPSPVNPLPAPRTKRARPNVLASSPDLSAVNKEVASKVMANSQQNGLPRAFHSQENMNLRSRFGDSNELNTSQKLTMWSSGSNQEKNNVSVQRELGSQSWMQMRRPDGSSEILSGFQPLKDTRNPLSSFPSQISGNRSNTWNTINVHYPDQNANHNMYPGTWSLMPPNTGFGVNQQNYLMTPDITLPQRSLNAKFGGNGAFTSLRAHGIDQRSSGWLGHIEPSSHIDDASSSLIKPQPLVIDHNVQKAKGSSCMLFGISLDSPAKPELLISPPSVAFDGKLQQDALEEDECSDPSKTVKPLDGAQHDSAREKHQSCPDGTKNIQSKQQNGSSRSCKKVHKQGIALGRSIDLTKFTCYDELIAELDQMFDFNGELNSSSKNWMVVYTDNEGDMMLVGDDPWNEFCNMVHKIFIYTREEVQKMNPGALNSRSEDSRSTSVERGLVGEGLQGGLSTPSLNSENC
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).
What are the official names of this protein?
Auxin response factor 24.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IHFA_CAUVC
Sequence: MKGATLTRADLCEAVHEEVGLTRQDCAGLVERTLDLVAEALEQGETVKLSGFGVFQVRAKRARMGRNPKTGEPAEIEPRRVIGFRASQVMKARIDRALGG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: AB14G_ARATH
Sequence: MPQNCIAPRPEEDGGVMVQGLPDMSDTQSKSVLAFPTITSQPGLQMSMYPITLKFEEVVYKVKIEQTSQCMGSWKSKEKTILNGITGMVCPGEFLAMLGPSGSGKTTLLSALGGRLSKTFSGKVMYNGQPFSGCIKRRTGFVAQDDVLYPHLTVWETLFFTALLRLPSSLTRDEKAEHVDRVIAELGLNRCTNSMIGGPLFRGISGGEKKRVSIGQEMLINPSLLLLDEPTSGLDSTTAHRIVTTIKRLASGGRTVVTTIHQPSSRIYHMFDKVVLLSEGSPIYYGAASSAVEYFSSLGFSTSLTVNPADLLLDLANGIPPDTQKETSEQEQKTVKETLVSAYEKNISTKLKAELCNAESHSYEYTKAAAKNLKSEQWCTTWWYQFTVLLQRGVRERRFESFNKLRIFQVISVAFLGGLLWWHTPKSHIQDRTALLFFFSVFWGFYPLYNAVFTFPQEKRMLIKERSSGMYRLSSYFMARNVGDLPLELALPTAFVFIIYWMGGLKPDPTTFILSLLVVLYSVLVAQGLGLAFGALLMNIKQATTLASVTTLVFLIAGGYYVQQIPPFIVWLKYLSYSYYCYKLLLGIQYTDDDYYECSKGVWCRVGDFPAIKSMGLNNLWIDVFVMGVMLVGYRLMAYMALHRVKLR
What is the function of this protein?
(Microbial infection) Required for SNC1-mediated defense response against the virulent pathogen Pseudomonas syringae pv.  tomato DC3000 by promoting the accumulation of trans-zeatin (tZ)-type cytokinins (CK) in the shoot.
What are the official names of this protein?
ABC transporter G family member 14, ABC transporter ABCG.14, AtABCG14, Protein INSENSITIVE TO TEMPERATURE 211, White-brown complex homolog protein 14, AtWBC14.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL18_NEIG1
Sequence: MDKHTTRLRRARKTRARIADLKMVRLCVFRSNNHIYAQVISAEGDKVLAQASTLEAEVRGSLKSGSNVEAAAIVGKRIAEKAKAAGVEKVAFDRSGFQYHGRVKALAEAARENGLSF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TILS_THESQ
Sequence: MLEEGEHVLVAVSGGIDSMTLLYVLRKFSPLLKIKITAAHLDHRIRESSRRDREFVERICRQWNIPVETSEVDVPSLWKDSGKTLEEIAREVRYDFLKRTAKKVGASKIALAHHKNDLLETVVHRLIRGTGPLGLACISPKREEFIRPFLVFKRSEIEEYAREKGVPYVVDETNYDVKYTRNFIRHRIVPLMKELNPTVEDAVYRLVSVTHLLRNFVERTVQDFVERNVYFYKDYAVFVEPEDLFLFLEVTRWVLKEMYGRVPEYEKLIGTLKSKRVEFWSGIFVERSFGYVAVGKTVFKKKYRVEVKGDMLEMEGFKIRVVNNRNDMKFWVRNRKEGDRIIVNGRERKLKDVFIEKKVPTFYRDRVPLLVDEEDRVLWVPGIARSDFLPEDVVVELLEYPVGYVKGGTYFEQV
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERLN2_HUMAN
Sequence: MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDEPLETATKEN
What is the function of this protein?
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376).  Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306).  Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.  May promote ER retention of the SCAP-SREBF complex (PubMed:24217618).
What are the official names of this protein?
Erlin-2, Endoplasmic reticulum lipid raft-associated protein 2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2, SPFH domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Protein: NRAM_I34A1
Sequence: MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNSTWVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKIFKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIWDPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKTIWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: MTAD_BACHK
Sequence: MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGEFASDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDMLLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKEDEKKAIEEAERYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENRTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIAHGVVLNDSERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKRVVWNGECKTLDEERIIFEASRYKRGLQR
What is the function of this protein?
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively.  Is also able to deaminate adenosine.
What are the official names of this protein?
5-methylthioadenosine/S-adenosylhomocysteine deaminase, MTA/SAH deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Protein: NTPPA_THEP3
Sequence: MKIVLASKSPRRRELLSNLGLDFEVIESNVEEFSSEKHPSRYVMDLSFNKAMSVAKKLKEEAIVIGADTIVVIEDKVLGKPKDRDEAFIMLKNLQGRVHTVYTGITIVRTKDFKYVSDFEETKVWIKKLEDEEIFNYIDTGEGYDKAGAYAIQGVGALIVEKIEGDYFNVVGLPISKLFDILKREFDVRLL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O169_CONVE
Sequence: MKLTCMKIVAVLFLTAWTFVTADDSRNGLEYLFPKAHYEMNPEASKLNKKQDCAAGGQFCGFPKIGGPCCSGWCLGVCA
What are the official names of this protein?
Conotoxin VnMKLT1-01122.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RELX_BALED
Sequence: QSTNDLIKACGRELVRLWVEICGSVSWGRTALRMTLSEKCCQVGCIRKDIARLC
What is the function of this protein?
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
What are the official names of this protein?
Relaxin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISF1_YEAS6
Sequence: MIASEIFERGVQDPFCQDCDYEDETDVQSFLGSNDLNDFVNSKLASFSFQNSSKSNNSHHSSSTNAGNTSRHIGNHTIGHHLRKIKTAPHHLYGFVPANSTNNSNEPIRPSPRRIRANSSTLIHQLSRQSTRQSSLGDAADSCFDHKCIKPRSRHSSCYGIPTHLYGLEKYVSSELDSLAVANDQSNDLTSPLTSVSTPASNSNSYLNLNSSSAAYPSSYLSNEKNNRLKLISHGKISSNNVPGHSGNLNHYHRERTPSNLRRESFSLLSNGSSSSPLQTRNNSYSNSLVKSPSNSSLNTSVASSNEESIPHTSNCLEERNPRRKSFIKLSLASSFSN
What is the function of this protein?
Could influence the NAM7/UPF1 function, possibly at the level of mRNA turnover.  Participates in mitochondrial biogenesis (By similarity).
What are the official names of this protein?
Increasing suppression factor 1, Mitochondrial biogenesis regulation protein 3.
What is the protein family that this protein belongs to?
Belongs to the ISF1/MBR1 family.
Protein: CF418_HUMAN
Sequence: MAEDLDELLDEVESKFCTPDLLRRGMVEQPKGCGGGTHSSDRNQAKAKETLRSTETFKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRACDHLRCIACDFLVVSYDDYMWDKSCDYLFFRNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH
What is the function of this protein?
May be involved in photoreceptor outer segment disk morphogenesis (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 418.
What are the subcellular locations of this protein?
Cytoplasm. Photoreceptor inner segment. Note=In the retina, located at the base of the primary cilium (PubMed:22177090). Expressed throughout photoreceptors cell body including the basal body, inner segment and synaptic terminus, but not in the outer segment.
Protein: DRD3_CHLAE
Sequence: MAPLSQLSGHLNYTCGVENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRVCCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVTLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDRAHLELKRYYSICQDTALGGPGFQERGGELKREERTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
What is the function of this protein?
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.  Promotes cell proliferation (By similarity).
What are the official names of this protein?
D(3) dopamine receptor, Dopamine D3 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CATB_RAT
Sequence: MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
What is the function of this protein?
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:1639824).  Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity).  Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity).  Has also been implicated in tumor invasion and metastasis (By similarity).
What are the official names of this protein?
Cathepsin B, Cathepsin B1, RSG-2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome. Melanosome. Secreted, extracellular space. Apical cell membrane; Peripheral membrane protein; Extracellular side. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Protein: MAP2_HUMAN
Sequence: MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
What is the function of this protein?
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR.  Plays a critical role in the regulation of protein synthesis.
What are the official names of this protein?
Methionine aminopeptidase 2, MAP 2, MetAP 2, Initiation factor 2-associated 67 kDa glycoprotein, p67, p67eIF2, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes.
Protein: Y1691_BRUO2
Sequence: MSDDITSEAQTIAVGQLRAFIERIERLEEEKKTIGDDIKEVYAELKGSGFDSKVVRTIIRLRKKEDHERQEEEAMLQLYMDALGMS
What are the official names of this protein?
UPF0335 protein BOV_1691.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: DBP8_CRYNJ
Sequence: MAVSKKSRKSEPSAAFTAADGLVLDQSEIMRAMLAAQKGKQKEESEGNDESDEEDDDVSNEGEDEGESSGSEAESSVAAQRNLKRRRSLSFELDAEGEEDKENEESEPRPQPSSGAGMLSRTALATKDMTPKPRSKPQPNGLASASKPSADVTFESLGLSHPLITALASINIKKPTEIQAACVEPILSGRDCIGGAKTGSGKTMAFALPIVERIARDPFGVWAVVLTPTRELAYQLSEQFLVIGKPLGLTTATIVGGMDMMKQAQELEARPHIIVATPGRLCDLLRSGGVGPGKLSRVRTLVLDEADRMLTPSFAPELAYLFSQIPAKRQTCLFTATVSEAIMELANKEPPAGKQRPFVYRVASDTLTVSNLKQKYLFIPSQIRDPYLLYILQNPLEDIDVALRVDPKKAKAREREAALGKKGKKPRQAKEEEDAPSVPSTVIFTQRCATAHLLHLLLNSLDIPSVPLHSHLTQPQRLLSLARFRAHEVPVLVTTDVGSRGLDIPEVAMVINWDCPRRSDDYVHRVGRTARAGRGGVAVTIITERDTELVKIIEDEVNVRLEELKLDEDKVLEGLNKVSLARRMATMEMHDSGFGERQATNKAKQIKRMKRDAAAAGKA
What is the function of this protein?
ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites.  Required for vegetative growth (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL6_BIFLS
Sequence: MASHIGKLPIAIPAGVEVKIEGQNFSAKGAKGSDSYVVPEGITAAVEGNEIVLTAADDLRPTRAKHGLARSIMAGMVKGVHDGYSKTLEIVGTGYRAVAKGKGIEFFLGYSHTITVNPPEGITLKVTDANHVVVEGTDKQVVGQVAANIRKLRAPEPYKGKGIKYADERILRKAGKAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: CHI2_METRA
Sequence: MHHLRALVGVGLAGLAAGVPLTDKISVKPRQAPGAQNVVYWGQNGGGTIENNDLAAYCQPNSGIDVLVLAFLYQFGNGGNIPSGTIGQSCYISTSGQGQNCEALTAAIHTCQSAGVKIILSLGGATSSYSLQTQAQAEQIGQYLWDSYGNSGNKTVQRPFGSNFVNGFDFDIEVNGGSSQYYQYMIAKLRSNFASDKSNTYLITGAPQCPIPEPNMGVIISNSVFDHLYVQFYNNNNYTVPCALGINGNAPFNYNNWTSFIADTPSAGAKIFIGVPASPLASTGTPSGAQYYAAPDQLAAIVGEYRSDAHFGGIMMWSAGFSDANVNNGCTYAQQAKSILVNGAPCASSGPPSSTPATAPAPTATTMPSSTSVSSPAASPTGGTVPQWGQCGGEGYSGPTQCVAPYQCVKQGDWWSSCR
What is the function of this protein?
Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods).  Participates in the infection process and directly acts in the penetration process of the host cuticle (By similarity).
What are the official names of this protein?
Endochitinase 2, Chitinase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DLX1_RAT
Sequence: KLMKQGGAALEGSALANGRALSAGSPPVPPGWNRIPPLGRAQEE
What is the function of this protein?
Plays a role as a transcriptional activator or repressor.  Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation.  Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina.  Likely to play a regulatory role in the development of the ventral forebrain.  May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.
What are the official names of this protein?
Homeobox protein DLX-1.
What is the protein family that this protein belongs to?
Belongs to the distal-less homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PODO_RAT
Sequence: MDSRARSSSRKTHGRGSRSSSRDDKKSKAGRGNRGRARPDAGAERQSAGRTGTREEHRAPAATVVNVDEVRSPGEEGTEVVALLESERPEEGIKPSGLGACEWLLVLSSLIFIIVTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRSLTEILLERKSIAQDVKVALDSVTCVWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAAEGEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTDKPSTVVLPLPFDMLNLLSSPSNRAQGSINYPSSPKPVEPLNPKRKDSPML
What is the function of this protein?
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
What are the official names of this protein?
Podocin.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.