PharMolix/UniProtQA huggingface dataset:
Protein: OAZ_ASHGO
Sequence: MMEQLRKKEQHIAKVVGECSTQGAVSVSFSTVQLAKGTCLEKLRPWMLRYRCSSRTGYAEWLADRAGAQSVRMAELLELYWDLIAVVEARFAVVPSEVEEERFYRRFQAHVVRRVGRRITCTARGRACAEDKYPDFQQIGDMYGAVGDEQGVHLYKWVQSSRRLLVLMDERAAGRVDLKRWLVMMMELVDGARMLRGCQALQVYVSREDLVNVKDLLKNLNWIGGELVQNVGDRWSDDEAMVWSDERYVVIRFDC
What is the function of this protein?
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels.  Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.
What are the official names of this protein?
Ornithine decarboxylase antizyme.
What is the protein family that this protein belongs to?
Belongs to the ODC antizyme family.
Protein: ENGB_PSYA2
Sequence: MSAPTFRLCPADIGLEVAFAGRSNAGKSSAINALTNQRQLARSSKTPGRTQMINFFNVGDADRRLVDLPGYGYAAVPLEMKKEWQVELEEYLVSRSSLAGLVLMTDIRHPLKFFDEQMLRWAKDGELPVHILLTKADKLKYGASKNALLNTRKRLKQLGLNCSIQLFSALRKEGLDELAGVMGNWYEYQLEANKIIESSFALLEGSELEDAIEKDAVQKDKNLKDSAQKESK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: QCR8_KLULA
Sequence: MGGPHAKAYMGWWGSIGSPAQKGITTYTVSPYAQKPLNNIFHNAVFNTFRRVKSQILYMALPAALYWAWWVNCRDYNAYLYTKAGREELERVNV
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 8, Complex III subunit 8, Complex III subunit VII, Ubiquinol-cytochrome c reductase complex 11 kDa protein, Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C.
What is the protein family that this protein belongs to?
Belongs to the UQCRQ/QCR8 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: CD27A_ARATH
Sequence: MMENLLANCVQKNLNHFMFTNAIFLCELLLAQFPSEVNLQLLARCYLSNSQAYSAYYILKGSKTPQSRYLFAFSCFKLDLLGEAEAALLPCEDYAEEVPGGAAGHYLLGLIYRYSGRKNCSIQQFRMALSFDPLCWEAYGELCSLGAAEEASTVFGNVASQRLQKTCVEQRISFSEGATIDQITDSDKALKDTGLSQTEHIPGENQQDLKIMQQPGDIPPNTDRQLSTNGWDLNTPSPVLLQVMDALPPLLLKNMRRPAVEGSLMSVHGVRVRRRNFFSEELSAEAQEESGRRRSARIAARKKNPMSQSFGKDSHWLHLSPSESNYAPSLSSMIGKCRIQSSKEATTSGQSVSDIGSSVDDEEKSNPSESSPDRFSLISGISEVLSLLKILGDGHRHLHMYKCQEALLAYQKLSQKQYNTHWVLMQVGKAYFELQDYFNADSSFTLAHQKYPYALEGMDTYSTVLYHLKEEMRLGYLAQELISVDRLSPESWCAVGNCYSLRKDHDTALKMFQRAIQLNERFTYAHTLCGHEFAALEEFEDAERCYRKALGIDTRHYNAWYGLGMTYLRQEKFEFAQHQFQLALQINPRSSVIMCYYGIALHESKRNDEALMMMEKAVLTDAKNPLPKYYKAHILTSLGDYHKAQKVLEELKECAPQESSVHASLGKIYNQLKQYDKAVLHFGIALDLSPSPSDAVKIKAYMERLILPDELVTEENL
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins.  The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation.  Involved in the control of endoreduplication.  Functionally redundant with CDC27B in the control of gametophyte development.
What are the official names of this protein?
Cell division cycle protein 27 homolog A, CDC27 homolog A, Anaphase-promoting complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the APC3/CDC27 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPPH_SHESR
Sequence: MIDSDGFRANVGIIICNRYGQVMWARRFGQHSWQFPQGGVDDGETAEEAMYRELYEEVGLRPEHVTILTSTRSWLRYRLPKRLVRQDSKPVCIGQKQKWFLLQLKSQDSAINLSSSGHPEFDDWRWVSYWYPVRQVVSFKRDVYRKVMKEFAVTALSFQTQEIPRKRVRQRTTG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: FSQB_ASPFU
Sequence: MSIPNSFIIVGSGVFGLSLAYALSLDDRFADKKIILVDRWNFEPPNATGSVHNPAAANADTSRVIRRDYPHGPYASLALEAMKHWRGKFGENNRYVNQRLLFSGEGSSLTTPPKALETVNYIKKAYAISCELTPGGRDAVQVLDSLDEVRAFLGNTPSHPPHLPVNKDPAARDLRGYVSNDCGWADAGASIEWLRQEVLRLGRVECVVGEVESLVYSDDQRAVKGVKLVDGKVLTAELTVIAAGARSSHILGIPKLCDVYSEFVAYIQLTKEEADELRRRQWPILVNCHRGVFAVGPDHDNCLKFGHFSYSGIVDVLREASIQVPTRPDGWEAQQKYWSDPRFAFGGEVKVSALGDVDDYENPAAQRALADYRLFLLELLGPTGLQGVDTLGLDQSDNLLNNIANRPFTRVRKCWYNDTPALDFVVDYHPSYGKTLFVATGGCDHAFKFLPIIGEKTLALILRNRGDSAVSLPAGVEPSLEELSELWRFPVELLQDN
What is the function of this protein?
Is able to convert N-methyl-3,4-dihydroxy-DL-phenylalanine (N-methyl-DOPA) directly into cyclic isoquinoline, in vitro (PubMed:27065235, PubMed:30194285).  The absence of the meta-hydroxyl group, as in L-N-methyl-tyrosine, leads to a 25-fold lower rate of reduction and the formation of the demethylated product L-tyrosine, instead of a cyclic product (PubMed:30194285).  Does not accept the D-stereoisomer of N-methyltyrosine, in contrast to N-methyl-DOPA, for which both stereoisomers are oxidized with similar rates (PubMed:30194285).
What are the official names of this protein?
Amino acid oxidase fsqB, Fumipyrrole biosynthesis protein A, Fumisoquins biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family.
Protein: RSMJ_ECOLC
Sequence: MKICLIDETGTGDGALSVLAARWGLEHDEDNLMALVLTPEHLELRKRDEPKLGGIFVDFVGGAMAHRRKFGGGRGEAVAKAVGIKGDYLPDVVDATAGLGRDAFVLASVGCRVRMLERNPVVAALLDDGLARGYADAEIGGWLQERLQLIHASSLTALTDITPRPQVVYLDPMFPHKQKSALVKKEMRVFQSLVGPDLDADGLLEPARLLATKRVVVKRPDYAPPLANVATPNAVVTKGHRFDIYAGTPV
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIT1_BOVIN
Sequence: MLGFIIRPPHQLLSLLSCPGLRIPRFSVLCAPPRLRTMAASSSFSELPLVAVCQVTSTPDKEQNFKTCAELIREAARLGACLAFLPEAFDFIARDPEETRRLSEPLSGNLLEEYTQLARECGLWLSLGGFHERGQDWEQTQKIYNCHVIMNNMGSVVATYRKTHLCDVEIPGQGPMRESNSTIPGPSLESPISTPAGKIGLAICYDMRFPELSLALVQAGAEILTYPSAFGSVTGPAHWEVLLRARAIETQCYVVAAAQCGRHHEKRASYGHSMVVDPWGTVVARCSEGPGLCLARIDLNYLQQLRKQLPVFQHRRPDLYGNLGHPLS
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione.  Plays a role in cell growth and apoptosis.  Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells.  It is also a negative regulator of primary T-cells.
What are the official names of this protein?
Deaminated glutathione amidase, dGSH amidase, Nitrilase homolog 1.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: S45A2_MOUSE
Sequence: MSGSNGPTDTHTYQSLAEDCPFGSVEQPKRSTGRLVMHSMAMFGREFCYAVEAAYVTPVLLSVGLPKSLYSMVWLLSPILGFLLQPVVGSASDHCRARWGRRRPYILTLAIMMLLGMALYLNGDAVVSALVANPRQKLIWAISITMVGVVLFDFSADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYILGAIDWVHLDLGRLLGTEFQVMFFFSALVLILCFITHLCSIPEAPLRDAATDPPSQQDPQGSSLSASGMHEYGSIEKVKNGGADTEQPVQEWKNKKPSGQSQRTMSMKSLLRALVNMPSHYRCLCVSHLIGWTAFLSNMLFFTDFMGQIVYHGDPYGAHNSTEFLIYERGVEVGCWGLCINSVFSSVYSYFQKAMVSYIGLKGLYFMGYLLFGLGTGFIGLFPNVYSTLVLCSMFGVMSSTLYTVPFNLIAEYHREEEKEKGQEAPGGPDNQGRGKGVDCAALTCMVQLAQILVGGGLGFLVNMAGSVVVVVITASAVSLIGCCFVALFVRYVD
What is the function of this protein?
Proton-associated glucose and sucrose transporter (PubMed:25164149, PubMed:35469906).  May be able to transport also fructose (PubMed:25164149).  Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis (PubMed:32966160, PubMed:35469906).  Regulates melanogenesis by maintaining melanosome neutralization that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR (PubMed:32966160, PubMed:35469906).
What are the official names of this protein?
Membrane-associated transporter protein, Melanoma antigen AIM1, Protein AIM-1, Protein underwhite, Solute carrier family 45 member 2.
What is the protein family that this protein belongs to?
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Melanosome membrane; Multi-pass membrane protein.
Protein: CAPSD_OCSVU
Sequence: MTLNLRKVPAYLPGKVDGALTNLVHAAVDHVVPGLGKAEKAAAVYNIKQVVKKLGTYTEQGVKKIAKKTLGELGYLNYTPSSHLGMAITGRGTKQINMSRSTNAGGFALGGTTAAPVSISRNINRRSKPSIKMMGDAVVISHSEMLGAINSGTPSSNVTAFRCTGYRANPGMSTIFPWLSATAVNYEKYKFRRLSFTLVPLVSTNYSGRIGVGFDYDSSDLVPGNRQEFYALSNHCENMPWQESTVEIKCDNAYRFTGTHVAADNKLIDLGQVVVMSDSVSNGGTISAALPLFDLIVNYTVELIEPQQALFSSQLYSGSTTFTSGIPLGTGADTTTVVGPTVVNSTTVTNCVVTFKLPAGVFEVSYFIAWSTGTAAVVPTVPTTGAGSKLSNTSTGSNSYGVCFINSPVECDLLLTATVLLIIPTLPSSTCVFHAPARRCTTPMCHRLLTSLAG
What is the function of this protein?
Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 28-34 nm in diameter, and consisting of 180 capsid proteins.
What are the official names of this protein?
Capsid protein, p48.
What is the protein family that this protein belongs to?
Belongs to the icosahedral plant coat protein family.
What are the subcellular locations of this protein?
Virion.
Protein: CLPP_CLOB1
Sequence: MSLVPVVVEQTNRGERSYDIYSRLLKDRIIMLSEEVNDTTASLIVAQLLFLEAEDPDKDIHLYINSPGGSITSGMAIYDTMQYIKPDVSTICVGMAASMGAFLLAAGAKGKRYALPNSEVMIHQPLGGFRGQATDIGIHAERILKMKKKLNTILSDRTGKPLEQVELDTERDHFLSAEEAKEYGLIDEVIDKKK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_NOSS1
Sequence: MKLLISNDDGISALGIRTLANALAEAGHDVTVVCPDRERSATGHGLTLHQPIRAEIVESIFHPAIKAWACDGTPSDCVKLALWALLESPPDLVLSGINQGANLGTEILYSGTVSAAMEGMIEGIPSIAFSLTSHISRNFQPAAKFATILVEQLAAKPIPDLMLLNVNIPPVEWEEIAGVKLTRQGVRRYVDVFDKRTDPRGKTYYWLTGEVLEEVEPPEGLNLPQNVPIDVHVVRNNYISITPLQYNLTYATGIDKLSDWDFPLS
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y981_METJA
Sequence: MEMTEKIYLKCENCGFEEQEVLKKKIYNKSAYYLVRCPNCGSVREIVDKVKLSQAKLIISRYDISESKVINIPEDETYKVGDTIEIDGEKIEITKIETPESVKSALGEDIKVIWGKSLSIPKKLGISINDRSKTYGIYIYVPNDFEFEVEKVYRINDGFFRLKKIKTEKGTAKKAKAKDIKRLYGDVTRPVRNYVDLSEFYKGE
What are the official names of this protein?
Uncharacterized protein MJ0981.
Protein: ISPG_ECOLU
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQRVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: VIRB3_BRUA2
Sequence: MTTAPQESNARSAGYRGDPIFKGCTRPAMLFGVPVIPLVIVGGSIVLLSVWISMFILPLIVPIVLVMRQITQTDDQMFRLLGLKAQFRLIHFNRTGRFWRASAYSPIAFTKRKRES
What is the function of this protein?
The virB operon is essential for intracellular survival and is not involved in the invasion process.  Constitutes a major determinant of virulence in mice.
What are the official names of this protein?
Type IV secretion system protein virB3.
What is the protein family that this protein belongs to?
Belongs to the virB3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PHS_SHEON
Sequence: MTALTQMKCEACQADAPKVTDEELAELIRMIPDWGVQVRDGIMQLERVYKFKNFKLAMAFTNKLAELAEEEFHHPGILTEWGKVTVTWWSHSIKGLHKNDFIMAAKTDLLLD
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: H4_CHAVR
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL7_RHOP5
Sequence: MADLQKIVDDLSSLTVLEAAELAKLLEEKWGVSAAAAVAVAGPAAAAAAPAEEKTEFTVVLASAGDKKIEVIKEVRAITGLGLKEAKDLVEGAPKPVKEGVNKDEAEKVKAQLEKAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: BCL6_CHICK
Sequence: MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIIVNREQFRAHKTVLMACSGLFYSIFTDQLKCNLNVINLDPEINPEGFCILLDFMYTSRLNLRENNIMAVMATALYLQMEHVVDTCRRFVKSSEAEMVSAVKTPREEFLAGRMLNHPEVMAYRGRDVSENSMPLQNGSLCNGRAFAPGLFNSLPGSSISYPGYSPLPLNGFLVDDELREMRMPLSELSRVSAFPKERIPCDGSRTIPAEYMRTITDISANMCHATIYSPKEGAAEEARSDMHYSVASGPKPVVPSIRNNPYFSCDKVAKEEERTSSEDEISQHFEPTNTPLDRKGLISPQSPQKSDCQPNSPTESSSSKNARISQNSNSLFTKSPTDPKACNWKKYKFIVLNSLNQSTKQDSADQNEMGTLSPRTYMPMSTCQQSMEPEHLNVQSPTKMSVNGEDSNIPQASRLNNIVNRSRDGSPRSSEGQSPLYMHSSKCSSCGCQSPQHTEMCLHTSGSAFGEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHSLQVHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRISANEVPPELPKAC
What is the function of this protein?
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions.  Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes.  Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors.  In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression.  An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response.  In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells.  Also required for the establishment and maintenance of immunological memory for both T- and B-cells.  Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2.  In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners.  Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation (By similarity).
What are the official names of this protein?
B-cell lymphoma 6 protein homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL19_BURP1
Sequence: MNLIAKLEQEEIERALAGKTIPEFAPGDTVIVNVNVVEGNRKRVQAYEGVVIAKRNRGLNSSFIVRKISSGEGVERTFQTYSPLLASIVVKRRGDVRRAKLYYLRERSGKSARIKEKLVSKDRAAAAQQ
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MTNC_MARN8
Sequence: MIRVILTDIEGTTSSISFVHDVLFPYASEHLPEFIRANHHTLPAVAEQLVRVAEISGTDRKDIDGLINVLQEWIAEDRKEGALKALQGMVWEQGYHSGELKGHIYPDAADYLKRWHDRGLRLFVYSSGSVKAQKLIFGHSNEGDFTVFFSGYFDTAVGGKKESQSYRNILAELGVDAGTVLFLSDVEEELRAAEEAGLKTAWLVREGELPDTARVVARDFSEVDALLRKR
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: ACP_BARBK
Sequence: MSDTEERVKKIIVEHLGVDADKVVQNASFIDDLGADSLDTVELVMAFEEEFGIEIPDDAAETIFTVNDAVKFIDKASS
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPRA_ECO57
Sequence: MDSSFTPIEQMLKFRASRHEDFPYQEILLTRLCMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIQPSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEFLREVLPPQHNCLHQLWSALSTTEKDQLEQITRKLLSRLDQMEQDGVVLEAMS
What is the function of this protein?
Negative regulator of the multidrug operon emrAB.
What are the official names of this protein?
Transcriptional repressor MprA, Protein EmrR.
Protein: FBIA_STRAW
Sequence: MRIVVLAGGIGGARFLRGLQRAAPDADITVIGNTGDDIHLFGLKVCPDLDTVMYTLGGGINEEQGWGRADETFHLKEELAAYGVGPEWFGLGDRDFATHIVRTQMLGAGYPLSAVTQALCDRWKPGVRLIPMSDDRIETHVAVDMDGERKAVHFQEYWVRLRASVPAVAVVPVGAEQAKPAPGVLEAIAEADVVLFPPSNPVVSVGTILAVPGIREAIAEAGVPVVGLSPIVGDAPVRGMADKVLAAVGVESTAAAVAEHYGSGLLDGWLVDTVDASVVERVEAAGIRCRAVPLMMTDLDATAQMAREALALAEEVRTP
What is the function of this protein?
Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
What are the official names of this protein?
Phosphoenolpyruvate transferase, EPPG:FO PEP transferase.
What is the protein family that this protein belongs to?
Belongs to the CofD family.
Protein: CHZ1_NEOFI
Sequence: MGDNHQATLSNDPAANAPDAAAADKGKGKAADEPSLEMSMDEEEDSDESEAEEMVNDDDDDHDNLEPISEENIISGGRRTRGKTIDFQEAAEKLKAEDEMDDEDDDDEEFQPNDEDMRD
What is the function of this protein?
Forms a chaperone-bound H2A. Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A. Z histone replacement in chromatin.
What are the official names of this protein?
Histone H2A.Z-specific chaperone chz1.
What is the protein family that this protein belongs to?
Belongs to the CHZ1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL30_KLEP3
Sequence: MAKTIKITQTRSAIGRLPKHKATLLGLGLRRIGHTVEREDTPAVRGMVNAVSFMVKVEE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: TRMFO_SYMTH
Sequence: MTEPHVTVIGAGLAGSEAAWQAARLGVKVTLYEMRPHVTTAVHRTGLFAELVCSNSLRGAGLENAVGLLKEEMRRLGSLILREALQHAVPAGGALAVSREEFAAGVTAALTSHPNITVVREEVREIPPDGVVVIASGPLTSAPLAEAIRRFTGEESLAFYDAAAPIVNIETVNMDKVFRMSRYGKGEGDDYLNCPLTREEYEAFYEALVTAEKAMPHNPEDAQVCFFEGCLPVEEIARRGPDALRYGPMKPVGLIDPRTGRRPWAVVQLRQDNAAGTLYNMVGFQTSLKWSEQKRVFRMIPGLEEAEFERYGVIHRNTFMKSPRLLYPTGESRQRAGLFFAGQMTGVEGYVESAAGGLVAGINAARRALGLEPVTFPRETAIGSLLHYITHADPEHFQPMNIAFGLMPPLEGPKIRDKRARKRAISERALDVLAAWAPGHLGAPLLD
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.