PharMolix/UniProtQA huggingface dataset:
Protein: Y1865_ARCFU
Sequence: MGVYHISGVGFRPGAVTVPLTAVYTLQIAQALGIEEAKEFFKYSSEAEKKGSYEMTKGIPEVLVVFTSRDVIEGRKKLEYKSNWFSLSGGSEEKVEKPIVKYLKKLFRHIEKNFNLEFCLKKFYLVKVDHQNFDDCFEKIGVILRALKDKEVWGNMIGGTNQINLAMLTAGAYTATISKYYYLFQNDVALMEPEWIDKPSNKNIRQATIEILKKWQELPIFNLEMGSIMKDISNLFGGRGFVNIREVERILENYGLGKQFLTKFRGRILEFEEDKVSKGIMFDKIVNLWNLISDVDVRNVLREWKDTGVIREVDINEIRCD
What are the official names of this protein?
Uncharacterized protein AF_1865.
Protein: OR74A_DROME
Sequence: MSFHRYRPRLPGGELAPMPWPVSLYRVLNHVAWPLEAESGRWTVFLDRLMIFLGFLVFCEHNEVDFHYLIANRQDMDNMLTGLPTYLILVEMQIRCFQLAWHKDRFRALLQRFYAEIYVSEEMEPHLFASIQRQMLATRVNSTVYLLALLNFFLVPVTNVIYHRREMLYKQVYPFDNTQLHFFIPLLVLNFWVGFIITSMLFGELNVMGELMMHLNARYIQLGQDLRRSAQMLLKKSSSLNVAIAYRLNLTHILRRNAALRDFGQRVEKEFTLRIFVMFAFSAGLLCALFFKAFTNPWGNVAYIVWFLAKFMELLALGMLGSILLKTTDELGMMYYTADWEQVIHQSDNVGENVKLMKLVTLAIQLNSRPFFITGLNYFRVSLTAVLKIIQGAFSYFTFLNSMR
What is the function of this protein?
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates.  The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration.  May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.  Involved in the behavioral responses to octanol, anisole, and 2-heptanone.
What are the official names of this protein?
Odorant receptor 74a.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y678_AQUAE
Sequence: MLIVLLALLLLSCSPKYKIVKEYVLPQNTLCVQDCKEKFLECKKACFESYNACLKESVERARKVYLSLLKDYERKSREYEKAYENYLKELRTYRETLYRIKEDLKFYERICSAYKDKEACDKKEWLKKRIRFYERRKPLPPQKPTMPSYEILLKREREACSCECGCEKLYDACFESCRGKVRIKKVCVENCD
What are the official names of this protein?
Uncharacterized protein aq_678.
Protein: Y2439_SYNY3
Sequence: MQAQTFSHLHSQSSQRTTEVTLYLTIPESYRQEPIVTQLVSRYQLQVNILAATLGTNGGQGQFKLTLIGHAQAINNALAYLEQLQVTIVLDQESDGW
What is the function of this protein?
May have a regulatory function.
What are the official names of this protein?
Uncharacterized protein ssr2439.
Protein: ISL1_DANRE
Sequence: MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCNIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERATMGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSILMKQLQQQQPNDKTNIQGMTGTPMVATSPERHDGGLQANQVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
What is the function of this protein?
DNA-binding transcriptional activator.  Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes.  Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation.  May be involved in subtype specialization of primary motoneurons.  May bind to insulin gene enhancer sequences.  Essential for heart development (By similarity).
What are the official names of this protein?
Insulin gene enhancer protein isl-1, Islet-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEXA_VIBC3
Sequence: MKPLTPRQQEVFDLIKSKIDETGMPPTRAEIAKELGFRSANAAEEHLKALARKQVIEMVPGASRGIRILVDNAANEEEAETGLPLIGRVAAGEPILAQEHVEAHYQVDPSMFRPQADFLLRVHGESMKNIGILDGDLLAVHKTQDVRNGQVVVARVEDDVTVKRLERKGSKVFLHAENEEFAPIEVDLAAQSLTIEGIAVGVIRNSTWM
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RRP36_PICST
Sequence: MRPSYNDDGFSDDEFTNSILTKRDEQDDSLESMTFGALNSAQNELLGKKKKKKSIQTESKKRKYSESESEEDSEDSEEESDSDSDAPPQENSSRGKTSRFQKNGEKKKRSKHAPAETSSKKPVSRIREIPGLKSSKESTLYTDIRFDPAYGKADLRKTRKDYAFLDEYRQSEVKSMETMLKDKKSGQMLSNRDREEIQLQLQSLKSRLDTMKNRDLEEKILADHKRNQIKGFKDGQQNNPYFLKRSDKRKLIQKAKFDSMKASQREKVMERKRKKRLGKEFRQLEFNQPRH
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DHR15_WHEAT
Sequence: MEFQGQHDNPANRVDEYGNPFPLAGAWGERTRSRHRRAVPGPQGRAQDRWILHRSGSSSSSSSSEDDGMGGRRKKGMKEKIKEKLPGGHKDNQQHMATGTGTGGAYGPGTGTGGAYGQQGHTGMAGAGTGTGEKKGIMDKIKEKLPGQH
What are the official names of this protein?
Dehydrin Rab15.
What is the protein family that this protein belongs to?
Belongs to the plant dehydrin family.
Protein: ODH_HALDH
Sequence: MTKKITVLVCGGGNGAHVTAGLAASRDDIETRVLTTFADEAERWTNIMKENDLRITVDEGDIKSGESVDFKVKLNCITKDPSKAVPGADVIIFTVPAFAHQSYLEAIEPYIQPNTTIVGMPGQPGFEFQVFDVLKDKAKQCVIMSFESLPWACRIAEFGKFVQILMVKVNLMGCLIRGQSKPSYDPMEAVQRVMGKAPILTQANNYIEPILATKSIIHPPIMYGKWKDWDGKPIEEKPLFYQGLDEEQARYLGGISDELVATAKAIAAQKPEVDLSGVLHLYDWYLRDHKPYIKDTTSLLTVLQTDTAYDGLVHPMKETEDGKFVPDFRYRYLTEDVPNGLVVTKGLAQIAGVPTPYHDEVIAWCQKQLGKEIIVGDELKGKDIGSTRCPQRYGINTMDALVNIM
What are the official names of this protein?
Opine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the lysopine/nopaline/octopine/opine/vitopine dehydrogenases family.
Protein: LEPA_XANC5
Sequence: MRNIRNFSIIAHVDHGKSTLADRIIQLCGGLQAREMEAQVLDSNPIERERGITIKAQSVSLPYTAKDGQTYHLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAVEQGLEVVPVLNKIDLPTADVDRAKAEIEAVIGIDAEDAVAVSAKTGLNIDLVLEAIVHRIPPPKPRETDKLQALIIDSWFDNYLGVVSLVRVMQGEIKPGSKILVMSTGRTHLVDKVGVFTPKRKELPALGAGEVGWINASIKDVHGAPVGDTLTLAGDPAPHALPGFQEMQPRVFAGLFPVDAEDYPDLREALDKLRLNDAALRFEPESSEAMGFGFRCGFLGMLHMEIVQERLEREYNLDLISTAPTVVYEVLKTDGTVINMDNPAKLPQLNLVQEIREPIIRANVLTPEEYIGNIIKLCEEKRGTQIGINYLGSQVQISYELPMAEVVLDFFDKLKSVSRGYASLDYHFVRFDAGPFVRVDVLINGDKVDALSLIVHRSHADRRGRELCEKMKDLIPRQMFDVAIQAAIGSQIISRSTVKAMRKNVLAKCYGGDVSRKKKLLEKQKEGKKRMKQVGRVEIPQEAFLAVLQMDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MLTF_YERE8
Sequence: MTRIKLNYFVIGVVALLLALALWPNIPWRNGQEGQLDRIKARGELRVSTISSPLIYSTGKDGPSGFDYELAKRFADYLGVKLVMTPHHNINDLFDTLDSDDADMIAAGLIYNSERLKRARTGPAYYSVSQQLVYRLGSPRPKSFSDLKGQLIVASGSAHMTTLKQLKQTKYPDLNWGSSVDRSGKELLEQVADGKLDYTLGDSVTIALLQRIHPQLAVAFDVTDEEPVTWYFQQSHDDSLYAAMLDFYSEMVEDGSLARLEEKYLGHVGSFDYVDTKTFLSAIDNVLPSFRPLFEKHAGEIDWRLLAAIAYQESHWNPQATSPTGVRGLMMLTRATASGLGVKDRVDPEESIRGGSVYLQRLMQKVPDTIPEDERIWFALAAYNLGYGHMLDARKLTKNQNGNPDSWVDVKMRLPMLSQKRYYPSTTYGYARGHEAYNYVENIRRYQVSLVGYLQEKEKKAAQHAAIEAELGKAYPVVGPGWSINN
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: GLNB_SALTI
Sequence: MKKIDAIIKPFKLDDVREALAEVGITGMTVTEVKGFGRQKGHTELYRGAEYMVDFLPKVKIEIVVPDDIVDTCVDTIIRTAQTGKIGDGKIFVFDVARVIRIRTGEEDDAAI
What is the function of this protein?
P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA).  P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA.  When P-II is uridylylated to P-II-UMP, these events are reversed.  When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).
What are the official names of this protein?
Nitrogen regulatory protein P-II 1.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: PSBA1_SYNP6
Sequence: MTTALQRRESASLWQQFCEWVTSTDNRLYVGWFGVLMIPTLLTATICFIVAFIAAPPVDIDGIREPVAGSLMYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVVFHFLIGVFCYMGREWELSYRLGMRPWICVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMFVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTSLGISTMAFNLNGFNFNQSVLDSQGRVINTWADVLNRANLGMEVMHERNAHNFPLDLAAGEATPVALTAPAING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1 1, PSII D1 protein 1, Photosystem II Q(B) protein 1.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: CYB_COLGU
Sequence: MTSTRKSNPIMKMVNHAFIDLPTPSNISMWWNFGSLLATCLLLQIITGLFLAMHYSPDTSSAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHVGRGLYYGSFLLLETWNIGILLLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWVWGGYSIDKPTLTRFFTIHFTLPFIIVALTTLHLLFLHETGSNNPCGIISNSDKIPFHPYYTTKDILGLTLLLLLLMMLVLFLPDLLSDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSVPNKLGGVLALLLSILILMAMPMLHKSKQQSMTFRPLSQLMLWLLTTTLITLTWIGSQPVNQPFIMIGQMASMTYFTTILILMPLASLTENKLLKWT
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CMOB_ECOLI
Sequence: MIDFGNFYSLIAKNHLSHWLETLPAQIANWQREQQHGLFKQWSNAVEFLPEIKPYRLDLLHSVTAESEEPLSAGQIKRIETLMRNLMPWRKGPFSLYGVNIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGAHLAVGIDPTQLFLCQFEAVRKLLGNDQRAHLLPLGIEQLPALKAFDTVFSMGVLYHRRSPLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSALALKNWLKKCGFVDIRIADVSVTTTEEQRRTEWMVTESLADFLDPHDPGKTVEGYPAPKRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.  Can also catalyze the SAM-dependent methylation of ho5U, with much lower efficiency.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: PSBB_IPOPU
Sequence: MGLPWYRVHTVVLNDPGRLLSVHIMHTALVAGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWSITGGTVTNPGIWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLSGLACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQPVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSAGLAENQSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPIFRDKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVAFYGGELNGVSYSDPTTVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFLKLGDPTTKRQAA
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ACEK_ACIAC
Sequence: MFPRRLDSPAAYGIAQAMMDGFDRHYRLFRAESARAKHRFETSDWSGQQRAQRERIEFYDLRVKECVRRLEKEFSAGAQPMDVWHQVKLHYIGLLVGHRQPELAETFFNSVTTKILHRTHFHNDFIFVRPAISTEYLENDEPGARPTYRAYYPTPESLQETLVRVVDNFQLQGEFEDLARDAGRVAEVMRPRLGPAKWRANFQIQVLSSLFYRNKGAYLVGKVINGFQELAFALPILHGTDGRYVIDAALFGEDDLQMLFSFARAYFMVDMEIPSAYVQFLRSLMPRKPRAELYNALGLAKQGKTLFYRDFLHHLRYSSDRFRIAPGIKGMVMLVFDLPSFPFVFKVIKDYYPPQKDTTREQIKGKYLLVKQHDRVGRMADTLEYSEVAFPRERFEDDLIAEIEKFAPSQLEISDRDGDGNVEVILKHVYIERRMIPLNIYLQEAFDAGPHDARARQQMERSVVEYGNAIKDLVAANIFPGDMLWKNFGVTRNGKVVFYDYDEIEYLTDCHFRRVPAPRNEEDELSGEVWWAVGPRDVFPETFGPFLLGNDAVREVFMRHHADLLDPVFWQSHKERIQAGHMYDVFPYDPERRFGAGTGSPA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD22_HUMAN
Sequence: MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
What is the function of this protein?
Mediates B-cell B-cell interactions.  May be involved in the localization of B-cells in lymphoid tissues.  Binds sialylated glycoproteins; one of which is CD45.  Preferentially binds to alpha-2,6-linked sialic acid.  The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface.  Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling.  Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
What are the official names of this protein?
B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RPOC_MICLC
Sequence: MSTDNSFGLMRIGLATAEDIRRWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECACGKYKRVRFKGIICERCGVEVTRSKVRRDRMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKVIYFAAYMITSVDEEARHRDLANLQAEYDQETRVLADQRDSDIAAVAADLEKDLAKLESEGAKAAEKKKARDAADKTMAQIRKRADAELDRKEQVWDRFKNLKVADLEGDEGLYRAMRDKYGQYFEGSMGAEAIQRRLQTFDLEAESEMLRETIKTGKGQRKTRALKRLKVVNAFLTTDNSPEGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPEIIVNNEKRMLQEAVDSLFDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKQMALELFKPFVMKRLVDLNHAQNIKSAKRMVERFRPQVWDVLEEVITEHPVLLNRAPTLHRLGIQAFEPQLVEGKALQLHPLVCSAFNADFDGDQMAVHLPLSPEAQAEARLLMLSSHNILKPSDGRAVAVPAQDMIIGLNHLTTVRPDEVGAGNLYATVGEAIMAFDGGDLHLNAPARIGVEGFVPSAAVPAPEGWSEGEIALIETTLGKVLFNELLPDDYPWLDKQATKGTLGQLVNDLAERYPMVVTAQTLDNLKDAGFHWGTWSGVTVAISDITSDFDKAAIMEGYEEQAQRVQQQYDKGLIADDERRSELIDIWNKATDEVAAAMKDGLPELNTINRMVSSGARGNWLQVRQIAGIRGLVANPKGEIIPRPIKSSYREGLSVLEYFSATHGARKGLADTALKTANSGYLTRRLVDVSQDVIVREDDCGTERGLSVTIAAPNADGELVAHEQVENSAFARTLAQDVTGEDGTVLAAAGADVGDVLIGELVAAGVTEIKVRSVLTCESAVGTCAKCYGRSMATGQLADIGEAVGIIAAQSIGEPGTQLTMRTFHTGGVASADDITQGLPRIQELFEARTPKGVAPISEVAGRVTIEDTETSVRLLLTPDDGSEEIAYPVLRRARILVADGEHVPVGTQLVAGAVDPKQVLRVLGPRAAQRFLVDEVQNVYQSQGVGIHDKHVEVIVRQMLRRITVIESGDTDLLPGELTDRARFVAANRAAVAEGRQPASGRDELMGITKASLATDSWLSAASFQETTRVLTQAAMEGKSDPLLGLKENVIIGKLIPAGTGLDRYTKTVVEPTEEAKANLFASPAGFADFDYPGLDQSLGENDFHAVSLDDYDRGGDFRA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: EFTS_STAHJ
Sequence: MAISAKLVKELRERTGAGMMDCKKALTETDGDIDKAIDYLREKGIAKAAKKADRIAAEGLVHVEVKGNEAAIVEINSETDFVARNEGFQELVKEIANQVLDSKAETVDALLETKLSSGKTVDERMKEAISTIGEKLSIRRFEIRTKSDNDAFGAYLHMGGRIGVLTVVEGSTDEEAAKDVAMHIAAINPKYVSSEQVKEEEINHEREVLKQQALNEGKPENIVEKMVEGRLRKYLQEICAVDQNFVKDPDQTVEAFLKSKGGKLVDFVRYEVGEGMEKREENFADEVKGQMK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMTB_METCA
Sequence: MALMTWTAAEFGTNVGFADDQHKTIFDMVNKLHDTAATGNRSEIGKQLDALIDYVVMHFKSEETEMQKKGYADFAAHKAEHDKLVGVCADLQKKFHAGEAEVNQDTTRFVRDWLVNHIPKVDKLYGPCLSA
What is the function of this protein?
Oxygen-binding protein.  May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes.  The oxygen-binding site contains two iron atoms.
What are the official names of this protein?
Bacteriohemerythrin, McHr.
What is the protein family that this protein belongs to?
Belongs to the hemerythrin family.
Protein: SAHH_CORDI
Sequence: MAAFDYNVKDLSLAEAGRHQIRLAEYEMPGLMQLREEYQQEQPLAGARITGSIHMTVQTAVLIETLVALGAQVRWASCNIFSTQDEAAAAVVVGPHGTPEDPQGVPVFAWKGETLEEYWDCVDKIFSWGDELPNMILDDGGDATMAVIRGKQFEEAGMVPPVEEGDSDEYQAFLGMLRKTLAEQPGKWTAIAESVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGINRATDMLMGGKNVLICGYGDVGKGCAEAMAGQGARVKVTEADPINALQALMDGFPVVHVDQAIGDADIVITATGNMGIISFEQMLAMKDHAVLGNIGHFDNEIDMASLLHRDDVSRVTIKPQVDEFTLPNGKSIVVLSEGRLLNLGNATGHPSFVMSTSFADQTIAQIELFQNDGRYVNEVYRLPKILDEKVARIHVEALGGTITELTKEQAEYIGVDVAGPYKPEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXBB_SALTY
Sequence: MGNNLMQTDLSVWGMYQHADIVVKCVMIGLILASVVTWAIFFSKSVEFFTQKRRLKREQLQLADARSLDQASDIAAGFSAKSLSAQLINEAQNELELSQGSEDNEGIKERTGFRLERRVAAVGRYMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIAQTQTTNLAVVAPGIAEALLATAIGLVAAIPAVVIYNIFARQIGSYKATLGDVAAQVLLLQSRDLDLNASASAQPVRAAQKLRVG
What is the function of this protein?
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.  Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
What are the official names of this protein?
Biopolymer transport protein ExbB.
What is the protein family that this protein belongs to?
Belongs to the ExbB/TolQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PPNP_HAHCH
Sequence: MLKVNEYFNGRVKSIAFQTATLPATVGVMIPGDYEFSTSQHETMTVVSGALSVKLPESESWTRFNAGDRFEIPANATFNLKVAVDTAYLCTYG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: PROAM_OLEEU
Sequence: MSWQTYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVCGIYEEPVTPGQCNMVVERLGDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-3, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.