PharMolix/UniProtQA huggingface dataset:
Protein: RAD9_YEAST
Sequence: MSGQLVQWKSSPDRVTQSAIKEALHSPLADGDMNEMNVPVDPLENKVNSTNIIEGSPKANPNPVKFMNTSEIFQKSLGLLDESPRHDDELNIEVGDNDRPNANILHNERTPDLDRIANFFKSNRTPGKENLLTKYQSSDLEDTPLMLRKKMTFQTPTDPLEQKTFKKLKSDTGFCYYGEQNDGEENASLEVTEADATFVQMAERSADNYDCALEGIVTPKRYKDELSKSGGMQDERVQKTQIMISAESPNSISSYDKNKITGNGRTTRNVNKVFNNNEDNIGAIEEKNPVKKKSENYSSDDLRERNNQIIQSNESEEINELEKNLNVSGRENDVNNLDIDINSAVSGTPSRNNAEEEMYSSESVNNREPSKKWIFRYSKDKTENNSNRSTQIVNNPRTQEMPLDSISIDTQPLSKSFNTETNNELETQIIVSSLSQGISAQKGPVFHSTGQTEEIKTQIINSPEQNALNATFETPVTLSRINFEPILEVPETSSPSKNTMSKPSNSSPIPKEKDTFNIHEREVETNNVFSNDIQNSSNAATRDDIIIAGSSDFNEQKEITDRIYLQLSGKQISDSGSDETERMSPNELDTKKESTIMSEVELTQELPEVEEQQDLQTSPKKLVVEEETLMEIKKSKGNSLQLHDDNKECNSDKQDGTESLDVALIEHESKGQSSELQKNLMQLFPSESQEIIQNRRTIKRRQKDTIEIGEEEENRSTKTSPTKHLKRNSDLDAASIKREPSCSITIQTGETGSGKDSKEQSYVFPEGIRTADNSFLSKDDIIFGNAVWCQYTWNYKFYPGILLEVDTNQDGCWIYFETGRSLTKDEDIYYLDIRIGDAVTFDGNEYVVVGLECRSHDLNIIRCIRGYDTVHLKKKNASGLLGKRTLIKALSSISLDLSEWAKRAKIILEDNEKNKGDAYRYLRHPIRGRKSMTNVLSPKKHTDDEKDINTHTEVYNNEIESSSEKKEIVKKDSRDALAEHAGAPSLLFSSGEIRTGNVFDKCIFVLTSLFENREELRQTIESQGGTVIESGFSTLFNFTHPLAKSLVNKGNTDNIRELALKLAWKPHSLFADCRFACLITKRHLRSLKYLETLALGWPTLHWKFISACIEKKRIVPHLIYQYLLPSGESFRLSLDSPSKGGIIKSNNIFSFYTQFLRGSNLRDQICGVKKMLNDYIVIVWGRSELDSFVKFAFACLSAGRMLTIDLPNIDVDDTEPLLNALDSLVPRIGSELSNRKLKFLIYANENNGKSQMKLLERLRSQISLKFKKFNYIFHTESKEWLIQTIINEDTGFHDDITDNDIYNTISEVR
What is the function of this protein?
Essential for cell cycle arrest at the G2 stage following DNA damage by X-irradiation or inactivation of DNA ligase.
What are the official names of this protein?
DNA repair protein RAD9.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCSPB_CHLCH
Sequence: MKEPLIFDLSRPGRKGYSLSPCDVPEVPLESIIPASLLRKEAVELPEVAENEVVRHFVRLSNLNYHVDKNMYPLGSCTMKYNPKVNDYTCDLSGFSALHPLQPTSTTQGALQLMYELSNMLAEIAGMAGVSLQPAAGAHGELTGILLIKKYHEVRGDKRHKLLVVDSAHGTNPASAALAGYETISVKSNGDGRTDLEDLRSKLDGDVAALMLTNPNTIGLFEKEIVQIAEMVHANGSLLYMDGANMNALLGITRPGDMGFDVMHYNLHKTFAAPHGGGGPGSGPVGVNEKLLPYLPAPLVVKEGDTYRLTSGGDDSIGRMMNFYGNFAVLVRAYTYIRMLGAEGLRRVSENAIINANYLLSKLLERYELPYPKPVMHEFCLSGDKQKKAHGVKTLDIAKRLLDYGFHAPTIYFPLIVSEALMIEPTETESKETLDIFADALLAIAREAEENPDVVKMAPSTTAVKRLDEATASRQLTICCM
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: RL16_PARDP
Sequence: MLQPKRTKFRKQHKGRIHGEAKGGFNLNFGSYALKAIEPERVTARQIEAARRAITRHMKRQGRVWIRIFPDVPVSSKPTEVRMGKGKGSVDYWAARVHPGRIMFEIDGVNDTIAREALRLGAQKLPVLTRIVAREDW
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RL15_SHEFN
Sequence: MRLNTLSPAAGSKSAPKRVGRGIGSGLGKTAGRGHKGQKSRSGGGVRVGFEGGQMPLKIRLPKFGFTSRRALVTAEVRLLELAKVNGDVVDLNALKDANVITRNIQFAKIVLSGTIDRPVTVKGLKVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ANR53_HUMAN
Sequence: MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPLPDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDARLQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDFSSFLEVRPDGHGGARLHTVDGHWVAPVPRLPFEVLLRMLYPRVWPYRMKVPQGFYPISMREVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPTLPSPQTNP
What is the function of this protein?
Required for normal progression through mitosis.  Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 53.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle around the centrosome at prophase and prometaphase and at the spindle poles at metaphase and anaphase (PubMed:26820536).
Protein: NHAA_ACTPJ
Sequence: MLKQIQKFLKLEAASGILLLVSALLAMIFANTDLNQLYFSFLQTEVAIKFGAFSIDKPLLMWVNDGFMAVFFILVGMEVKRELFEGSLSSYQKAIFPAVAALGGMIIPALVYWFINQNSPEYQQGWAIPMATDIAFALGIVALLSKQVPPALKVFLLALAIIDDLGAIIVIALFFSHEMSMQALTIASIAIVILVAMNRYKVTGLINYAIIGTILWASVLKSGVHATLAGVIIGFCIPLRGKNGEAPLHHLEHALAPWCSFAILPLFAFSNAGVSLEGMSLDKLASPLPLGVALGLIIGKPVGVFLFSYVAVLLGIAKVPEGINLKQIFAIAVLCGIGFTMSMFIAGLAFGEEDASESVLALARLGILMGTFVAAIIGYFLLKITTKPSLMKAA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEA_SHIBS
Sequence: MRVTDFFFELPESLIAHYPMPERSSCRLLSLDGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGAELLLGDDESINATMTARHGALFEVEFNDDRSVLDILNSIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLEKLRAKGVEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQDVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKNDLIEPFFDDTQIFIYPGFQYKVVDALVTNFHLPESTLIMLVSAFAGYQHTMNAYKAAVEEKYRFFSYGDAMFITYNPQAINERVGE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_BART1
Sequence: MIQDNFFPLFPHKHLLAIKDLSVQDLNTLLDRAEANVILSNKIDKTKSILRGRTQINLFFEASTRTQSSFELAGKRLGADVISVAIGNSSVKKGETLFDTAATLNAMKPDILVFRHSSAGAAALLAQKVDCCVINAGDGAHEHPTQALLDALTIKRAKGRIEGLTVAICGDILHSRVARSNILSLNALGARVRAVAPSTLLPTEINHMSVEVFNTMKDGLKDADVIMMLRLQHERMTGSFIPSTREYFHYFGLHKENLTYAKNNCIILHPGPINRGVEIASDIADGPQSMIRTQVEMGIAVRMAVMEALLDSRLKINGEKK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: PP1R8_MOUSE
Sequence: MAAAVNSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRMEGSGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSETGSQPHGIHGTALIGGLPMPYPNLAPDVDLTPVVPSAVAINPTPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI
What is the function of this protein?
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1).  It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates.  May also be involved in pre-mRNA splicing.  Binds DNA and might act as a transcriptional repressor.  Essential for cell proliferation and early embryonic development.
What are the official names of this protein?
Nuclear inhibitor of protein phosphatase 1, NIPP-1, Protein phosphatase 1 regulatory inhibitor subunit 8.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Mainly, but not exclusively, nuclear.
Protein: ARP2_HUMAN
Sequence: MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
What is the function of this protein?
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076).  Seems to contact the pointed end of the daughter actin filament (PubMed:9000076).  In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690).  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947).  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
What are the official names of this protein?
Actin-related protein 2, Actin-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein: CAPSD_CAMVE
Sequence: MAESILDRTINRFWYNLGEDCLSESQFDLMIRLMEESLDGDQIIDLTSLPSDNLQVEQVMTTTDDSISEESEFLLAIGETSEDESDSGEEPEFEQVRMDRTGGTEIPKKEDGAEPSRYNERKRKTTEDRYFPTQPKTIPGQKQTSMGILNIDCQTNRRTLIDDWAAEIGLIVKTNREDYLDPETILLLMEHKTSGIAKELIRNTRWNRTTGDIIEQVIDAMYTMFLGLNYSDNKVAEKIDEQEKAKIRMTKLQLCDICYLEEFTCDYEKNMYKTELADFPGYINQYLSKIPIIGEKALTRFRHEANGTSIYSLGFAAKIVKEELSKICALSKKQKKLKKFNKKCCSIGEASVEYGCKKTSKKKYHNKRYKKKYKVYKPYKKKKKFRSGKYFKPKEKKGSKQKYCPKGKKDCRCWISNIEGHYANECPNRQSSEKAHILQQAEKLGLQPIEEPYEGVQEVFILEYKEEEEETSTEESDGSSTSEDSDSD
What is the function of this protein?
Self assembles to form an icosahedral capsid, about 50 nm in diameter, nm, composed of 420 subunits of the viral capsid protein.  The capsid encapsulates the genomic dsDNA.  Following virus entry into host cell, provides nuclear import of the viral genome.  Virus particles do not enter the nucleus, but dock at the nuclear membrane through the interaction with host importins (By similarity).
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the caulimoviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: YAJD_ECO57
Sequence: MAIIPKNYARLESGYREKALKIYPWVCGRCSREFVYSNLRELTVHHIDHDHTNNPEDGSNWELLCLYCHDHEHSKYTEADQYGTTVIAGEDAQKDVGEAKYNPFADLKAMMNKKK
What are the official names of this protein?
Putative HNH nuclease YajD.
What is the protein family that this protein belongs to?
Belongs to the HNH nuclease family.
Protein: DAPE_BRUAB
Sequence: MTLPVNPVDNLAALIRCPSVTPAEGGALTALEKMLKLMGFSANRPVFSDDNTPDIENLYARKSGNGPHLMFAGHTDVVPPGDEKDWKHPPFAAEIEDGVMYGRGAVDMKGGIACFVAAVARHIEKHGNIKGSISFLITGDEEGPAVNGTVKLLEWAKQRGESWDASIVGEPTNPNALGDMIKIGRRGSLSGTITVHGVQGHAAYPHLAENPVRGIVTLVDSLLYPAFDEGTANFQASNLEVTTIDVGNKATNVIPNKATASFNIRFNDTWTAESLQAEIISRLERAARDNRLRQGRETPIKYELTWRERPSHVFLTHDEKLIGTLTASVEAVTGKRPELSTSGGTSDARFIKDYCPVVEFGLTGQTMHMVDERVALADLEGLTQIYERFIADFFG
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: NSRR_ECOSE
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKSASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: LRIQ3_RAT
Sequence: MFHGTITKELTSHEEWSHYNENIVEDQKDFVFVKYNGLHLKSMENLQSCISLRVCIFSNNFVTDIQPLQGCKKLIKLDLHGNQIKTLPDRTFWNGLKNLKLLYLHDNGFAKLKNICVLSGCVNLVGLTMFDCPVSLKKGYRHVLVNSIWPLKALDHHVISDEEIIQNWHLPERFKTFSQSLFFNICPAPIKGTTYEDEIKNIKHIISRINEILAHNSPVLIIQRWIRGFIVRKHLSPYFTRKRHHDRMIRVLETKLICIGRNNEDKFLEDIFLIKPESNIKGKVAHWKQMRYSPDDFKYSTEYRKHISCLSYELKTKDIAGNSKQPRHHIQKGQNEMKSDSEDEEVDTKFRISAMKIPLCPSRSLKYRAMLKEIKWDYFPEYLQPLPATRQKPQVKRETHEELKERRNFLASQRAGMDLHLFNDIDKYYSEQRQQEEEARKFAATAAAQVAQERARLNTSENLRKKISMARKLMQKDNETIQKGLRHIWKERLNYLEKVRERKSMFLAEKKLNAADQSLVLSLNNERSILLRGIIQVDKLKRDLSEMKAKHFDVIEKREKRKYKQNLLTEMKKLRAEEIHKRHCEERFVIDTLIFQKGCERLEEAKAKVEFINTYYTSKSHKKYHNKTMLNHI
What are the official names of this protein?
Leucine-rich repeat and IQ domain-containing protein 3, Leucine-rich repeat-containing protein 44.
Protein: SYME_ECOLI
Sequence: MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESELMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system (PubMed:17462020).  Involved in the degradation and recycling of damaged RNA (PubMed:17462020).  It is itself a target for degradation by the ATP-dependent protease Lon (PubMed:17462020).
What are the official names of this protein?
Toxic protein SymE, Putative endoribonuclease SymE.
What is the protein family that this protein belongs to?
Belongs to the SymE family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Purifies with ribosomes.
Protein: KAD2_NEOFI
Sequence: MAPITEEVVHGLKDMIEKLENRVQELEGRLGGESKPKSIAEQMRIVLMGPPGAGKGTQAPRLKEKYCVCHLATGDMLRSQVAKKTELGKEAKKIMDQGGLVSDEIMVNMIKNELDTNTECKNGFILDGFPRTVAQAERLDDMLEARKQKLQHAIELQIDDALLVARITGRLVHPASGRSYHKIFNPPKNDMKDDVTGEPLIQRSDDNAETLKKRLSTYHAQTAPVVEYYKKTGIWRGIDASQEPGQVWKSLLGVFQK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: PSBJ_TRICV
Sequence: MSNTGRIPLWLVGLVGGLAVITMLSLFLYGAYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PLBL_DROME
Sequence: MLKVVGASWQKTRIGTYILIGAGLLVIGAFFIGYMERPEYDGTYCATALWTKQVGFQIENWKQQNDLVNIPTGVGRICYKDSVYENGWAQIEVETQRTYPDWVQAYAAGMLEGSLTWRNIYNQWSNTISSSCERDESTQKFCGWLRDLLTTNYHRLKRQTEKAENDHYWHQLHLFITQLEGLETGYKRGASRARSDLEEEIPFSDFLLMNAAADIQDLKIYYENYELQNSTEHTEEPGTDQPKNFFLPSATMLTKIVQEEESPQVLQLLFGHSTAGSYSSMLRIQKRYKFHYHFSSKLRSNTVPGVDITFTGYPGILGSTDDFYTIKGRHLHAIVGGVGIKNENLQLWKTVDPKKMVPLVARVMAANRISQNRQTWASAMSRHPFTGAKQWITVDLNKMKVQDNLYNVLEGDDKHDDAPVVLNEKDRTAIQQRHDQLRDMVWIAEQLPGMMTKKDVTQGFLVPGNTSWLANGVPYFKNVLELSGVNYSEDQQLTVADEEELTSLASVDKYLRTHGFRGDLLGSQESIAYGNIDLKLFSYNARLGISDFHAFAGPVFLRFQHTQPRTLEDEGQDGGVPPAASMGDERLSVSIEDADSLAEMELITERRSVRNDMRAIAMRKIGSGPFKWSEMSPVEEGGGHEGHPDEWNFDKVSPKWAW
What is the function of this protein?
Putative phospholipase (By similarity).  Involved in the regulation of cellular plasticity in imaginal disks.
What are the official names of this protein?
Putative phospholipase B-like lamina ancestor.
What is the protein family that this protein belongs to?
Belongs to the phospholipase B-like family.
What are the subcellular locations of this protein?
Secreted.
Protein: PKHO1_RAT
Sequence: MKKSGSGKRGPPDGNHQSVAPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYVSEKEVKDEKNSQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLARCRQPGTTAPNLIFLAVSPEEKESWINALSSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPASCAESFRVDLDKSVAQLAGSRRRADSDRIRPSSHRASSLSRPWERPDKGAPYTPQALKKLPSTEKSRCASLEEILSQRDTAPAHPLHLQAEESPAPVPSQPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKWKAKDPPRSPPDSQSEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTSQHSQYRKSLM
What is the function of this protein?
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).  May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2).  Appears to target ATM to the plasma membrane.  Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF.  When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).
What are the official names of this protein?
Pleckstrin homology domain-containing family O member 1, PH domain-containing family O member 1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Note=Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3- phosphate. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.
Protein: F135A_MOUSE
Sequence: MTEVQAMVEFSVELNKFYNVDLFQRGFYQIRASMKIPARIPHRVEASLLHATGMTLAFPASVHDALVCSKTFQILYKNEEVVLNDVMIFKVKMLLDERKIEETLEEISFLLSLGLHFTDGDYSADDLNALQLISSRTLKLHYSICRGLHHHANVMFDYFHLSVVSVTVHASLVALHQPLISFPRPVKTTWLNRNAPAQSKDSAIPTLESVVFGINYTKQLSPDGCSFLIAESFLHHAYHFHYTLCATLLLAFKGLHSYFITVTEEIPSCQKLDLEEMDVEARLTELCEEVKKVENPDELAELINMNLAQLCSLLMALWGQFLEAITLHEDLRVLLAQEHHTLRVRRFSEAFFCFEHPREAAIAYQELHAQSHLQMCTAIKNTSFCSSLPPLPIECSELDGDLNSLPIIFEDRYLDSVIEDLDAPWMGIQSLQISEASKTDKHETEESSVVGLSSPELKVRPAVASSNCYTEGEKQLTKSLKGKNEESNKSKVKVTKLMKTMKPENTKKLIKQNSKDSVVLVSYKCLKTTASSDFTKCLEGSPSHSQKEGLDPTLCAGNFDPKTYTRQPSQKEASSLSANTDRSEHKSPDTENMQPDQFELLNSGSLNLCANLSISGKLAISQDNSDIPDTEHNLASTSSSNDCHDYQTTPSSGVRTLEVKSSSKESFNGEKITVKIGPWTELQEAELFVDNLLPDFEALDSNDKPKSIDIPLERDALQETKCHSTEESLTKFRSNLPAPSTKEYHVAVSSDTIKLPDTNATYASSRFSDSGVESEPSSFATHPNPEIAFETLQGPGPCNNERLFPQLLMKPDHNVKFSLGSHCTESTSALSEIQSSLTSINSLPSDDELSPDDNCKKSAVPDCHLSDSKTVFNLGTMDLPKCDDTKKSSIILQQQSVVFSGHLDNDTLAMHSLDLSTEDPLRLVFLDEDASSGVRSSWGSKPHLDAPFTGPQSQGTSSNNSTESVPTLNSKLICLGSPCVVSGSVCTDAGLSADRTVEGKSGEPLNHKQVCSAAPVVESDPLSSSTDVVKQGLVENYFGSQSTTDVSDACAITCHSPVSSQETCDKGISDLQQEQGKEEEEEDQEMVQNGYHEETDFSATDGTVSVHYISGNELGEGRHEQSEKLSSNYLSAGVTVPAVCTSGCLSFPSALRESPCVKYSSRSKVDAITKQPSSISYNFSSSTSWYENSPKPQIHAFLQAKEELKQLRLPGFMYSDVPLLASSAPYFSMDEEDGSEDGVHLIVCVHGLDGNSADLRLVKTYIELGLPGGRVDFLMSERNQNDTFADFDCMTDRLLDEIIQYIQIYSLTVSKISFIGHSLGNLIIRSVLTRPRFKYYLSKLHTFLSLSGPHLGTLYNSSALVNTGLWFMQKWKKSGSLLQLTCRDHSDPRQTFLYKLSNKAGLHYFKNVVLVGSLQDRYVPYHSARIEMCKTALKDKQSGQIYSEMIHNLLRPVLQSKGCNLVRYNVINALPNTADSLIGRAAHIAVLDSEIFLEKFFLVAALKYFQ
What are the official names of this protein?
Protein FAM135A.
What is the protein family that this protein belongs to?
Belongs to the FAM135 family.
Protein: PFF1_COLGM
Sequence: MAVKNPFGFTTGPVTFWLIVVYAAFLIPLVWIHESVPAVPSSSKNPYPQLNVTEAWHDLTHITRKYHPYNSRANDEVGAYFMKRIEEILVRNKVEYTKEKDAGGVIWPQEAYDAPAPAKRDVQRRDSKGPAVTIFDDTISNTTYLGTSGSFNQAGAYGTYFEGTNKLVYIRGTLDEDGEWWNGKRDPRKIGQGGVLVNAHYDSVSSGYGATDDGMGCVSILQILNHYTSPGHQPMRGIVLLLNNGEEDGLYGAKVYHYSPLYYFTTSFVNLEGAGAGGRAILFRTTDLEVTKGYEGAPHPFGSVVAADGFKLGAIRSETDYKVWTESYGQRGLDIAFYRPRARYHTNQDDTRHASQESLWHMLSNSLAAVDNLQHTTGYFSGSRNDGDKKKVASGSGTDGVWFDMFGTGFAILELRGLFAWTLTLLIVSPLVLALVTYILSRKDKYYFFSRKVTADEDDEPVSVGGWKGFFRFPFALVLSASITVLSAFLIRRVNPHIIYSSPYAVWAMTLSLFFLVFWTIAKGASVVRPSALQRGYAHIWLFVISWVILVAVTAAADRFKIASGYPFAFFHSAVFVSALISLCDLFALPSKQEFARNAHNDQQTRDNISEVPNSDALISSRHSHVEDDVAEEPTETTPLRSGENGNGNNGTIRTTFATTYRRSLSAIMRTPDEEENKETEQQPYDHEQQWSANLPSWTWFFQLLLLAPITITVFLQIALFIVSAIHSAAADGNDPILVYAAIAAFSIIILLPATPFIHRASFYLPLFLLLVFFVTLIYNLVAFPFSAENRLKVRFQQTLDLDANTSVISITGLEKYTRKMIAELPSGAGQPVNCTPGYGLTSDCRYNGAAVMPNLPQFTHALPANVSKGRYANLVTVNISRSDSSSKLEFGIDAAESKVCNLAFDTPVSFNVRGSAGIDPIFSRPTEQGVRMLTLWRRDASIPWVVDVEPIKTKAVPAGVLAKSSDSDAGAVHEDLRVRKSAELSGTIACQWSDANVLGTIPAFDEALQFSPDWIAVTKASVGLVEGRKKFRA
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: HOA_SHEWM
Sequence: MNISNKKIILHDMCLRDGMHAKRHQISLAEMTQLATALDDAGVPLIEVTHGDGLGGNSVNYGFAAHSDEEYLSTVIPLMKQAKISALLLPGIGTVDHLRMAHELGVSTIRVAAQCTEADVTEQHISLSRQLGLDTVGFLMMAHMLEPKALLEQAKLMESYGANCIYCTDSAGYMLQDDVFERISVLRDGLKPDTQIGFHGHHNLALGVANSLTAVEAGAERIDGSAAGLGAGAGNTPLEVFNAVATRMGASTDVDVFKLMAAAEEIVVPMMDQAIRVDRDSLVLGYAGVYSSFLLHAKRAAEKYGVPSEAILLKLGQMKTVGGQEDMIEDVAINLAKSR
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase, HOA, 4-hydroxy-2-keto-pentanoic acid aldolase, 4-hydroxy-2-oxopentanoate aldolase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: EFTS_BURO1
Sequence: MAAITASMVAELRAKTDAPMMECKKALTEADGDLAKAEELLRVKLGNKASKAASRVTAEGVVASFVGGNAGALVELNCETDFVAKNDDFLAFSKTVAELVATQNPADVAALSALPLEGSTVDAVRLALIGKIGENVSIRRFVRFETANKIATYLHGARIGVIVEYTGAEEQVGKDVAMHIAAMKPVALSSADVPAELIDTERRVAEQKAAESGKPAEIVAKMVDGSVQKYLKEVSLLNQTFVKNDKQTIEQMLKAANATVQKFALFVVGEGIEKRQDDFAAEVAAQVAAAKQQ
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
Protein: Y3845_ORYSJ
Sequence: MGMGMEKGMTAYEAARERTVEENKRKMEALNLRHLSAAIAVAPKTPSPMKQKRRRIIEAAVVAPSPPRRSRRLANLPEVKYAEVAPDGAERMKRSPRKAIDSIYLATRGSISMEARLEAARKAEELESQLDPEFPSFVKPMLHSHVVRGFWLGLPRHFCETYLPKHDAIVTLLDEKDEQFDTNYLAYKNGLSGGWAGFALDHGLLDGDATVFQLVKPTTFKVHIIRATVDDGNEVTK
What are the official names of this protein?
B3 domain-containing protein Os03g0184500.
What are the subcellular locations of this protein?
Nucleus.