PharMolix/UniProtQA huggingface dataset:
Protein: MCAF1_DANRE
Sequence: MEVAVPEEPQKKIFRARKTMKMSDRQQLEVLHNTLATTNSSLSSSPPQTPLMNGTHTETEKDLNNKEGDLMAPATDSARCSPSPSFPVSRSPSPPNTQTTSPAMDLEDPLVATEEKKETSNKSSSSSPSASPAGLNCDPEVKEGFLCLSEEDETQADKDEKDSSEEKMNVDAETEDQKEEKDEKDTDTPENAEDNSAPVGLKRTLSEEKDEDDKEIEEERDGKRARLEGEELEAQLELKITANGGNRDKIEKMVQQLVEERLRVLQLTVFDRSLKELKDRVEKIDNVTKQQNALQHINTLQAKISRLAKKFGAANQASENAKRTQDAQAAAAAAQANNATNATTPQRTVKTTVDSKLSSSPTVSNSTAVPAQPKPLSTPATPTSSALATTAPILQIISTTTSSTPSSTSLPGQSQTGTLLLKTGPNPTVMTNAPATSGGQPVAMQQLLIQLPLAMANGQSGALVNAAGGVGLIPVSSLSTVSNINKAKTTTPATTFMLQKTAGNVSSATSSAPAVSLARAVYPGGTGTVSSPNTGISVTTARTPTQCAAVVGVSTAAASPGTTGPAATGSAAAAAGSPSASALASKTDNQASTPKTASQPGRPKGSVIDLTEDDDDVQVTGVQKATVSPVTTQRSSGPPPLVSSTPNTGTGVRSAQRSTVDSPSQSRPSSSSSTSLPPLPLAPSPPARLPPEANHTSPPQQPQLKLARVQSQNGIVLSWCVAETDRNCAAVDTYHLYAYHQDHQSSVSGASAQMLWKKIGEVKALPLPMACTLTQFVSGSTYYFAVRAKDVYGRFGPFCEPQCTDVITPASSAST
What is the function of this protein?
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation.  Can both act as an activator or a repressor depending on the context.  Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity.  May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity).
What are the official names of this protein?
Activating transcription factor 7-interacting protein 1, MBD1-containing chromatin-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the MCAF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARCH_THEMA
Sequence: MRKPIEHTADIAYEISGNSYEELLEEARNILLEEEGIVLDTEEKEKMYPLEETEDAFFDTVNDWILEISKGWAPWRIKREGNELKVTFRKIRKKEGTEIKALTYHLLKFERDGDVLKTKVVFDT
What is the function of this protein?
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB.  Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation.  Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).  May also act as a chaperone or modulator of proteins involved in DNA or RNA processing.
What are the official names of this protein?
Protein archease.
What is the protein family that this protein belongs to?
Belongs to the archease family.
Protein: SYM_CORGB
Sequence: MTKNVLVSVAWPYANGPRHIGHVAGFGVPSDVFARFQRMSGNNVLMVSGTDEHGTPLLVQADKEGVTVQDLADKYNRQIVEDLTGLGLSYDLFTRTTTSNHYAVVQELFRGLYDNGYMIKETTLGAISPSTGRTLPDRYIEGTCPICGTDGARGDQCDNCGNQLDPADLINPVSKINGETPEFVETEHFLLDLPALAEALTEWLKGREDWRPNVLKFSLNLLDDIRPRAMSRDIDWGIPIPVEGWQDNNAKKLYVWFDAVVGYLSASIEWAYRSGDPEAWRTFWNDPETKSYYFMGKDNITFHSQIWPAELLGYAGKGSRGGEIGDLGVLNLPTEVVSSEFLTMSGSKFSSSKGVVIYVKDFLKEFGPDALRYFIAVAGPENNDTDFTWDEFVRRVNNELANGWGNLVNRTVSMAHKNFGEVPVPGALEESDKKILDLATAAFESVAANLDQSKFKAGISEIMHVVGEANAYIAEQEPWKLAKDDTKRERLATVLWTALQVVSDCNTMLTPYLPHTAQKVHETLGRDGIWAASPQIVEVTNESPRQPIGVGLPDPEHTYPVIMGDYKTQLAKWQRIDVVPGTTLEKPAPLIAKLDPELGETGPEWAPVQN
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_BURVG
Sequence: MSRVGKSPIALQGAEVKLADGAITVKGPLGTITQPVNPLVNVANNDGTLNLAPVNESREANAMSGTMRAIIANAVHGVTKGFERKLTLVGVGYRAQAQGDKLNLSLGFSHPVVHQMPEGVKAETPTQTEIVIKGINKQQVGQVAAEVRGYRPPEPYKGKGVRYSDEVVILKETKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: POLI_MOUSE
Sequence: MEPLHAGAAGSSRAVCSQGPPTQISSSRVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNIMHRRLVVGSQIAAEMREAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNHDSMPPLIDILMKLFRNMVNVKMPFHLTLMSVCFCNLKALSSAKKGPMDCYLTSLSTPAYTDKRAFKVKDTHTEDSHKEKEANWDCLPSRRIESTGTGESPLDATCFPKEKDTSDLPLQALPEGVDQEVFKQLPADIQEEILYGKSRENLKGKGSLSCPLHASRGVLSFFSTKQMQASRLSPRDTALPSKRVSAASPCEPGTSGLSPGSTSHPSCGKDCSYYIDSQLKDEQTSQGPTESQGCQFSSTNPAVSGFHSFPNLQTEQLFSTHRTVDSHKQTATASHQGLESHQGLESRELDSAEEKLPFPPDIDPQVFYELPEEVQKELMAEWERAGAARPSAHR
What is the function of this protein?
Error-prone DNA polymerase specifically involved in DNA repair (PubMed:15026325, PubMed:16357261).  Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:15026325, PubMed:16357261).  Favors Hoogsteen base-pairing in the active site.  Inserts the correct base with high-fidelity opposite an adenosine template (By similarity).  Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (By similarity).  May play a role in hypermutation of immunoglobulin genes (By similarity).  Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).
What are the official names of this protein?
DNA polymerase iota, Rad30 homolog B.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Nucleus. Note=Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage.
Protein: NRDR_CORK4
Sequence: MFCPFCHHPQSRVIDSRTVENGFVTRRRRQCTKCHGRFTTVEKSVLLVEKRNGVTEDFSKDKLIRGVRRACQGRNVSDDALKLLAQEVEIDLRAQGGSRVNSNDVGLAVLEPLRKLDEVAYMRFASVYKSFSSMEDFEREITEFKARRSQ
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: ACRB_ASPFU
Sequence: MPRSSATARKSHSNRHENGSANTGKKVAKQKSNGHLNVNLNGGSASSSLSSSQVDLPSSRSSSDPVVPTTTAASTKLNGTPDSSKGDCNAPDHLNGYAKGNADMSYVQNDGVASQTGGDVAGPASRRTEKSATGSKRSPSNASVNPLQLASTILKSCPMYDTIAILIFLLQLPPMVLTLVQFLFASLTFLPPSGASAGSLTSNFDIFQGPAGTPSLGTMIAMDGFCLLIWGLFMWTWAQNFALDLAHVQVAITLGGGGFGKNGGVNTLCVGIVLIMHLVRSKGIQDFVIGHLLSSNIISPDMLSQYSHLLPTEFRRTEPQTSPSWLRSLLAVHILAQAGTAMARRSMAKNRTPNPPRTGKRIDTEASAGSQTQIDSAFESGASVSSYIGADGQIVTSAAHKDGRDRLLSAKKRRRQANQVRSRQPFWAALASTKITVMREYEHSRALSKTARSLPMTEDDLQGLSLDDGLVWITEIDSSTIKFAAGDFSSADDSSGSGACEAGCLGSEDMEPFYVCVNGALWATATICKVHDAPKGSSMVHWRGEISGLAPNCAYTCSFVRSDTDEEICVISVKTPANNDAEQVSSVSTPPHPSYRPSSPTTTLKNSIVNAEAKLNEKRSRLRKAKNDHKLIISKIRKELDNYNHRLHSGTDENRQKQRSLQLERNIRQTEEATALLEDQLDNLENVPEEELRKWSDQKAKYEHELGLLNSAKEELASARSAIAREVSSLETELSSAIQRRERLQSRRTRINEQYERIVSANAQGLNERERRAAEQFAREQDQAKLEATFNEQFATIGQSVQEYQLRAQQIWQQCDAIEQAIQQQHQQMLLDPGPLTPEGNLPGTNPFSESALPLGALTSTAPSSRSLLGLSFPPLKSSPLQTASSPVGASSSHPTSPVQQPSYLNFPTSPLVNASSHLDSDFVYRHRSFSNRSARSSLYGSDFMDSSRRQPFQLDLSELLADKRSPGSDSNTALNSGLRPVSSPFQRAGSRGSGSGSNGSGGSGSGSGSPSSVYGKTN
What is the function of this protein?
Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  Involved in resistance to acriflavine, and required for normal growth on a range of sole carbon sources, including fructose, cellobiose, raffinose, and starch, and reduced utilization of amino acids, including GABA and beta-alanine, as sole carbon and nitrogen sources (By similarity).
What are the official names of this protein?
Probable ubiquitination network signaling protein acrB, Acriflavine resistance protein B.
What is the protein family that this protein belongs to?
Belongs to the acrB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: P2RY2_MERUN
Sequence: LPLSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYAQGDHWPFSTVLCKLVRFLFYTNL
What is the function of this protein?
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system.  Not activated by UDP.
What are the official names of this protein?
P2Y purinoceptor 2, P2Y2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLGI_RHIL3
Sequence: MKLFFRFVTLVAVLAMSLANVAPAWALTSRIKDIASLQAGRDNQLIGYGLIVGLQGTGDGFRASPFTEQSMRAMLQNLGISTQGGQSNAKNTAAVMVTANLPPFASPGSRIDVTVSSLGDATSLRGGTLVMTSLSGADGQIYAVAQGAVIVSGFQAQGQAATVTEGVTTAGRVPGGAIIERELPSRFKDSVNLVLQLRNPDFSTAIRIADIVNGYASARFGGPVAEAKDSQEVVIQKPRAADLTRLMADVENLIVETDTPAKVVINERTGTIVIGSDVRVSPVAVSYGTLTVQVTETPQIIQPEPFSRGRTAVQPQTDIAAEQTGGRVAIIDGPDLRTLVAGLNNIGVKPDGIIAILQGIKSAGALQAELVLQ
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: KV5A4_MOUSE
Sequence: DIQMTQSPDYLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYDAKTLVEGVPSRFSGSGSGTQFSLKINSLQPEDFGSYYCQHHYGIPFTFGSGTKLEIKR
What are the official names of this protein?
Ig kappa chain V-V region MOPC 149.
Protein: RS9_SALEP
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRGELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: GLMS_MYCBO
Sequence: MCGIVGYVGRRPAYVVVMDALRRMEYRGYDSSGIALVDGGTLTVRRRAGRLANLEEAVAEMPSTALSGTTGLGHTRWATHGRPTDRNAHPHRDAAGKIAVVHNGIIENFAVLRRELETAGVEFASDTDTEVAAHLVARAYRHGETADDFVGSVLAVLRRLEGHFTLVFANADDPGTLVAARRSTPLVLGIGDNEMFVGSDVAAFIEHTREAVELGQDQAVVITADGYRISDFDGNDGLQAGRDFRPFHIDWDLAAAEKGGYEYFMLKEIAEQPAAVADTLLGHFVGGRIVLDEQRLSDQELREIDKVFVVACGTAYHSGLLAKYAIEHWTRLPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTIVIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_SHEHH
Sequence: MNNSYYVGLMSGTSMDGVDAVLVNFDGDQPSLIATHTEALPKALLSNLQKLCLPGNDEINRLGHLDRAMGKLFAKATNALLEKAGVDKSQVIAIGSHGQTVRHMPNLEMGFTLQIADPNTIAAETGIDVIADFRRKDIALGGQGAPLVPAFHQHVFANPNHQRIILNIGGIANVTYLPGNTQDVTGFDTGPGNGLSDAWIQHQLGQPFDKDGAWAASGTTDQKMLQHLLSHPYFALAAPKSTGRELFNQAWAEQQLSEFGHLSEADIQSTLLDLTCYSIANDALTLSDNGEMYVCGGGAYNCELMHRLRKLLPDYKVVTTSELGMDPQWVEGIAFAWLAMRHHNGLPGNLPAVTGASREAILGSFHPAD
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RSMG_THESQ
Sequence: MDSVKNILLEYGLRFQEPQIEKVDKYIEELLGVPYNLTAHRDLDSAVHKNVVEILLPLKEELKGTLLDVGSGNGVPGLILAIFFPKLKVVLLDSREKSVNFLRGVIEKLDLGNVSAVKERAENFSRERREEFDYVTARAVARLNVLVEICTPALKTGGKLLFYKGPSYIEELKEAQRAMKELKVELEEVREYSLKTGERRALLILRKYESSPEKYPRRVGVPFKRPLL
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYK_YERPG
Sequence: MSEQKPQVAEQAQELNSELQARREKLAVLRGKGIAFPNDFRRENLSDQLHAEFDSKENEELEALNIDVTVAGRMMTRRIMGKASFVTLQDVGGRIQLYVSRDDLPEGVYNEEFKKWDLGDILGARGKLFKTKTGELSIHCSELRLLTKALRPLPDKFHGLADQETRYRQRYLDLIANDESRHTFKVRSQVMSGIRSFMVEKGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIVLTEELFRTLTETILGSSVVQYGEQTFDFGKPFAKLTMKEAICKYRPETNVADLDDMDKAVAIAESLGIKVEKSWGLGRIQCEIFEETAESHLIQPTFITEYPAEVSPLARRNDDNPFITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQVSAKEAGDDEAMFYDEDYITALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE2_BURO1
Sequence: MKTSMKLDIVSVEAALYAGDAHFVVVPGESGELGIYPHHAPLLTRIRPGVVTLVDAPTGEHRRLLVAGGVLEVSRDGVTLIADHALRTPELDELRTREARHAADDWRQRYAHENRRAFDFASARAELMEEIRRFFAMALRQQAPHDKPGSAG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain 2, ATP synthase F1 sector epsilon subunit 2, F-ATPase epsilon subunit 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
Protein: CRT_PLAF7
Sequence: MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIFIYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSKERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYHLYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKIDILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVENCGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAYYFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDSIITQ
What is the function of this protein?
May regulate endogenous transporter.
What are the official names of this protein?
Putative chloroquine resistance transporter, PfCRT, Probable transporter cg10.
What is the protein family that this protein belongs to?
Belongs to the CRT-like transporter family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Localizes to the parasite digestive vacuole, the site of chloroquine action.
Protein: TX16A_ODOMO
Sequence: MRRSYVLLAFAIVLIISIISAQVEADASSDAFADAVADAVADPIKGKKIMKNMGKAMKIAGKVAKAMAPIVVPLIVSAAGK
What is the function of this protein?
Cationic amphipathic alpha-helical peptide with antimicrobial activities against E. coli (MIC=3. 1), and S. aureus (MIC=3. 1 uM).  Also shows histamine-releasing activity (33. 6% at 10 uM).  Does not have activity against S. cerevisiae.  Does not show hemolytic activity, even at 50 uM.
What are the official names of this protein?
U-poneritoxin(01)-Om6a, PONTX(01)-Om6, U-PONTX(01)-Om6a, Pilosulin-like peptide 6, PLP6, Poneratoxin.
What is the protein family that this protein belongs to?
Belongs to the formicidae venom precursor-01 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YCF4_NICSY
Sequence: MTWRSEHIWIELITGSRKISNFCWAFILFLGSLGFLLVGTSSYLGRNLISFFPPQQIIFFPQGLVMSFYGIAGLFISSYLWCTISWNVGSGYDRFDRKEGIVCIFRWGFPGKNRRIFLRFLIKDIQSVRIEVKEGISARRVLYMDIRGQGSIPLTRTDENLTPREIEQKAAELAYFLRVPIEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: ACCA_BACAN
Sequence: MAELEFEKPVVELRNKIRELKDYTKNSQMDFSEEIRILEDKLENLEEDIYGNMKVWDRVQIARHAERPTTLDYIEHLFTDFFECHGDRLFGDDAAIVGGIAKYKGMPVTVIGHQRGKDTKENIRRNFGMPHPEGYRKALRLMKQAEKFNRPIICFIDTKGAYPGKAAEERGQSEAIARNLFEMAGLTVPVICIVIGEGGSGGALGLGVGDYIHMLENSTYSVITPEGAAAILWKDAGKAKEAAEAMRITAADLKELGVIDEIIPEAKGGAHRNVLKQSENIDLMLRKTFEQLNGISKDELIEKRYEKYMKIGQVSFSNASIWIK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRSA_STRAM
Sequence: MRVLVRYASVMEACGLTVPPSRWRLALARMANRPAPESRPPRILRLRPTRTGLVLRLKLRPGQDAFDVAATTDRLRHSFGVYGVTSRELRSGVVEVRMTGYDVLQRVQMPATAETRPMRIPVALREDGAVHYRDYRAVPHGLTLGATESGKSVYQRNLVAGLAPHHVALVGIDCKQGVELFPLARRFSALADNPDTALDLLEALVGHMEDVYQLIRAEQRISVAVPDAEIAADIWDLREDLRPVPVVVLVDEVAELALFATKDEEKRRDRIITALVRLAQLGRAAGIYLEICGQRFGSELGKGITMLRAQLTGRTAHRVNDETSANMAFGDVSPDAVLAAIQIPTDTPGVAVTGDSTGGWARIRAPHTTLREAVNICNKHADRTPDVPALAAFRPALAPLPQARVPLSKTAPATA
What are the official names of this protein?
Transfer protein TraSA.
Protein: HLGA_STAAN
Sequence: MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
What is the function of this protein?
Toxin that seems to act by forming pores in the membrane of the cell.  Has a hemolytic and a leucotoxic activity (By similarity).
What are the official names of this protein?
Gamma-hemolysin component A, H-gamma-2, H-gamma-II.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: AMFR_HUMAN
Sequence: MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676).  Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410).  The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767).  In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569).  The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569).  In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676).  Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353).  Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408).  Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303).  Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303).  Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327).  In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040).  Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296).
What are the official names of this protein?
E3 ubiquitin-protein ligase AMFR, Autocrine motility factor receptor, AMF receptor, RING finger protein 45, gp78.
Protein: YIHI_ACTSZ
Sequence: MSRQKKSRRLTDVMPTRKADKKTEIGAVKARPGKKLTRYELDARAREEKRKRKHKGLDSGSRHSASSDSGKNQQTEVKDPRIGSRKKVPLVVEFVNKPEKGQFIQPIKTEKKPTALDPATELEQLENNECLNDLLDQLDAGKVLSKEDQVFVDECLARIAQLMDELGISDDEEGEDDLLRTFEKIDINQFR
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: VNPC_OXYMI
Sequence: SDSKIGNGCFGFPLDRIGSVSGLGCNRIMQNPPKKFSGE
What is the function of this protein?
Exhibits vasoactive and hypotensive activity (By similarity).  Produces a near complete relaxation in pre-contracted aortae by activating the natriuretic peptide receptor-A (NPR1).
What are the official names of this protein?
Peptide TNP-c, Taipan natriuretic peptide, Venom natriuretic peptide OxsSNPc.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: APL3_MANSE
Sequence: MAAKFVVVLAACVALSHSAMVRRDAPAGGNAFEEMEKHAKEFQKTFSEQFNSLVNSKNTQDFNKALKDGSDSVLQQLSAFSSSLQGAISDANGKAKEALEQARQNVEKTAEELRKAHPDVEKEANAFKDKLQAAVQTTVQESQKLAKEVASNMEETNKKLAPKIKQAYDDFVKHAEEVQKKLHEAATKQ
What is the function of this protein?
Assists in the loading of diacylglycerol, generated from triacylglycerol stores in the fat body through the action of adipokinetic hormone, into lipophorin, the hemolymph lipoprotein.  It increases the lipid carrying capacity of lipophorin by covering the expanding hydrophobic surface resulting from diacylglycerol uptake.  It thus plays a critical role in the transport of lipids during flight in several species of insects.
What are the official names of this protein?
Apolipophorin-3, Apolipophorin-III, ApoLp-III.
What is the protein family that this protein belongs to?
Belongs to the insect apolipophorin-3 family.
What are the subcellular locations of this protein?
Secreted.