PharMolix/UniProtQA huggingface dataset:
Protein: NTR2_YEAST
Sequence: MAIKKRNKIRLPSGSPEEVGIDGSAHKPMQQIKPLVSNDSEDDDNDICVLQPIKFKKVPKRDITFDGEQAIKEDNSHYEDLYHSKKNTNASTRNKDDLLILNMEDLMEGNHHLLSDSSEAGSSSEGEHISSIPTRGEIAKLKAQKSLSRRKISESDVTTERDYVKLLDSEDKREIMETIRLNGGLKRNNEKEITNFSDDEMQGFQDEMLALTDNQIAIQKDSKRKIIEKAINEVPYRTNEEWETQLLSKGNINKSNEKIITPLPVLFPDDDESGNSIERINEMVSKICLQRKKVEMRLQALEKTKIDLEKSKASLINKLIGN
What is the function of this protein?
Involved in pre-mRNA splicing and spliceosome disassembly.  Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43.  This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex.
What are the official names of this protein?
Pre-mRNA-splicing factor NTR2, Nineteen complex-related protein 2, NTC-related protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HRCA_STRPI
Sequence: MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDMAELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLEDILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQFLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFEHIFKEMFNENIVMAGKVHLLNFANLAAYQFFDQPQKVALEIREGLREEQMQNVRVADGQESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQVNVVNRVLTMKLTDFYRYLSSNHYEVH
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: MDR4_ENTH1
Sequence: MSVTTNAVADAFAVFDVTPDPDELARKNKKPDDSGSVTVRQLYRYANWLDLILLAVGIFGSIGCGVLTPCQMLVMGDMVDTFNTNDLMKAFPNQEAMYDPKYYIPFNHEVTKTVADTINDLVLKMVCFAIGSGVGSFLMTFCFFVMSERQGIKIRMLYFRALLRQDAGWYDFHESGELTSRIASDVQQIQDGMSQKFGIIFQTTTSFIAGYAIGFAKDWDLTLVIMSMSPFIVLSMTLLAVFATKFTVLGEESLGNAGAIAEATIGNMRTVHSLGQEHEFCEMYNEKIRVVDRYNVLKGLTVGLGLGAVMFFIMGAFSLGSWYASVVLRGKGGKKNVTAGDVMIVFICVLIATQGLSIIAIPLNIFATAKASAYRIYQTIDRIPDIDCRSTAGECPTECNGNITLEDVQFRYPTRPTKQILGGLDLEIKKGQTVALVGASGCGKSTTIQLVQRNYDPVGGSVKLDGKDLRDLNIKWLRNQIGLVGQEPILFACTIRENIMLGARDGETPTEEEMIECAKMANAHEFISHLPEGYDTMVGEKGAALSGGQKQRIAIARALIRKPTILLLDEATSALDTQSEKIVQQALEKASQGRTTIVVAHRLTTVRNASRICVFHQGEIIEQGTHQELMDLKGTYYGLVKRQSMEEEVDQETVENDLKKIREQENKEAEEINQHKNTDTNEDPDIVQKLENEYNSEMKKLKHSNRFVLLRVILDNFRHEWFLSTFGFIGGIGGGAIFPFFTLKIVDLIMCLLSINSDTLTDDQKDTIKNICIIVVVIGVASFLSFFMYIGLFLSAGFKMIGRVRKDMYHSIMHQNISWFDRKENMVGSLTTRLASDPTTLQGISGERVGNVIHIISTIGFALGIAFYYDWKVSLAVMAVSPVLIVVVFINGKLNSLEACPAQAAYEKSGITLVEAVESVRTVQSLTREEHFYEVFKDALREPKIGIYKWAPLLSIFMCLTTLLTQVMNPYGFYIGTYLIKKKSNYDLPVPDFMIEFSDRFEEMQKAIMAVIFAAQAVGNLGNIVPDIGKAVRAAKNTYDVIDRKPTIDCYSEEGETFNDVKGEIEFKDICFRYPTRPDNSVLKGISFKVEQGKTVALVGASGCGKSTSVQLIERFYDPTHGDVLLDGHNIKDLNIHFLRSQIGMVGQEPVLFAESVMDNIRRGVPKGVEVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGAQISGGQKQRIAIARALIRNPKVLLLDEATSALDSESEKIVQDALDKAAKGRTTIVIAHRLSTIQNADQICVIMRGRIAERGTHQELLDLKGFYYTLAMQQFGTVD
What is the function of this protein?
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug resistance parasites.
What are the official names of this protein?
Multidrug resistance protein 4, P-glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Protein: ARGB_CLAMS
Sequence: MTAIAQQAADRDQAQAESKAAILIESLSWLQRFHDRIVVVKFGGNAMVDEELTRTFAEDVVYLRYAGLRPVVVHGGGPQISAMLTRLGIDSEFRGGYRVTTPEVLEVVRMVLTGQVSRDVVRGINAHGPLAAAVSGEDAGLFTGRRRGAVVDGVEVDLGLVGDVVSVDPTAVLAQLDAGRIPVVSSIAPDESDPAVSLNVNADAAAAALAVALGAEKLVILTDVAGLYRDWPDRGSLVSDIRADELRALLPSLESGMIPKMAACLEAVDGGVPKAAIIDGRIPHSMLLEIFTTNGIGTEVVPA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SACB_NEIMA
Sequence: MFILNNRKWRKLKRDPSAFFRDSKFNFLRYFSAKKFAKNFKNSSHIHKTNISKAQSNISSTLKQNRKQDMLIPINFFNFEYIVKKLNNQNAIGVYILPSNLTLKPALCILESHKEDFLNKFLLTISSENLKLQYKFNGQIKNPKSVNEIWTDLFSIAHVDMKLSTDRTLSSSISQFWFRLEFCKEDKDFILFPTANRYSRKLWKHSIKNNQLFKEGIRNYSEISSLPYEEDHNFDIDLVFTWVNSEDKNWQELYKKYKPDFNSDATSTSRFLSRDELKFALRSWEMNGSFIRKIFIVSNCAPPAWLDLNNPKIQWVYHEEIMPQSALPTFSSHAIETSLHHIPGISNYFIYSNDDFLLTKPLNKDNFFYSNGIAKLRLEAWGNVNGECTEGEPDYLNGARNANTLLEKEFKKFTTKLHTHSPQSMRTDILFEMEKKYPEEFNRTLHNKFRSLDDIAVTGYLYHHYALLSGRALQSSDKTELVQQNHDFKKKLNNVVTLTKERNFDKLPLSVCINDGADSHLNEEWNVQVIKFLETLFPLPSSFEK
What is the function of this protein?
May be the polymerase that links individual UDP-N-acetyl-D-mannosamine monomers.  In serotype A the capsule is composed of repeated units of (alpha 1-6)-linked N-acetyl-D-mannosamine-1-phosphate (By similarity).
What are the official names of this protein?
Capsular polysaccharide phosphotransferase SacB, Stealth protein SacB.
What is the protein family that this protein belongs to?
Belongs to the stealth family.
Protein: VGR4B_PSEAE
Sequence: MFNPANQTHFSLSLDGLRHDLQVLEFSGHEGISRPYRFELELVSERAGLDLEALMHRPAFLAFTPQGQGVHGLVYGAAQGDAGKRLTRYRLTLVPHLAYLAQRNNQRIFQHLTVPQIVALILEEHGILADAYRFQLGTRYPEREYCVQYDESDLHFVQRLCAEEGIHFHFRHSAEAHLLVFGDDQTVFPRLGRPTAYVHDSGLVADEPVIKRFSLRLASRTTRTTRRDYDFEKPRLLLEAGNRPAADAPAEPDLEDYDYPGRFVDRQRGKLLSQRALERHRADRRLGEGVSDQPLLVSGHFLEIAEHPRAEWNDLWLLSEVFHEGKQPQVLEENVTSDTSASTDDFQQGYRNRFLATPWEVFFRPPLEHPKPRVLGSQTAVVTGPPGEEIHCDRYGRVRVQFHWDREGQGDDKSSCWLRVASGWAGNGYGGIVIPRVGMEVLVDFLEGDPDQPLVSGCVYHAAHPVPYELPANQTRSVFKSLSSPGGDGYNELRIEDRKGQEQIFVHAQRDWDENIEHDQKIRVGHERHDTVEANSYSEFKAEEHHTVHGERKVELKADDHLTVGDSQHVKLGRAYLARAGREIHLKAGQKMVIEADSELTVKAGGSFIRLDASGIAISGPLARINAGGAPGSGSGIAIKMPLTPGAADADVAGRPLQPANAGLHASDPKQNGEYRFDIRLQDIPGDEGFPLIHTPWRIVQGKEHNLVLEGESDEKGRLVLDDTQQRQLSNACERAPGDVWLVYPGQRIGIRPHREREGWDATRHALGALDFHDTLGGQRAPTPLEHQRGKLDSCCEGDLYSHLLAKD
What is the function of this protein?
Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection.  Allows the delivery of the phospholipase effector PldA to target cells where it exerts its toxicity.
What are the official names of this protein?
Type VI secretion system spike protein VgrG4b.
What is the protein family that this protein belongs to?
Belongs to the VgrG protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPE_SHESW
Sequence: MTAEHFPVTELAKDLISRPSVTPLDEGCQTLMAERLSAIGFNIEPMIFEDTTNMWARRGNQGPVFCFAGHTDVVPTGDISRWHTPPFEPTIIDGYLYGRGAADMKGSLAAMIVATERFVTKHPDHQGSIAFLITSDEEGPFINGTTRVIDTLEARKEKITWALVGEPSSTLKLGDVVKNGRRGSLTGNLTIKGIQGHVAYPHLADNPIHKAAPFLAELSQMHWDNGNEFFPPTSMQIANIHGGTGASNVIPGALEVMFNFRYSTEVTAEILIERVEALLKAHELDYDISWIFNGLPFLTGDGPLLDATRYAIHQVTGYDTSPQTTGGTSDGRFIAPTGAKVLELGPVNATIHKVNECVKVDDLEQLALCYEVILEQLLC
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: ZHD6_ORYSJ
Sequence: MEFRGHDEPVDEMGVAYGRTPPSSSSSPAASASAGNGAGAAEVRYHECLRNHAAAMGGHVVDGCREFMPMPGDAADALKCAACGCHRSFHRKDDGQQQQQLRLLIPSPPTPRVPLLMPPPQPQPHPHPQHPYLHPPFPYHHTPSGSGGTTTESSSEERGPPSSSAAAAQGRRKRFRTKFTPEQKEQMLAFAERVGWRMQKQDEALVEQFCAQVGVRRQVFKVWMHNNKSSIGSSSGGGSRRQPQEQQSQQQQQQQ
What is the function of this protein?
Putative transcription factor.
What are the official names of this protein?
Zinc-finger homeodomain protein 6, OsZHD6.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXD_FRATF
Sequence: MYSLDFLASKLDGEVKGDKNVEIKKIATLSQAGEGDISFCTNPKYLKALSETKASAVLITEEVLEFCNTNAVVLSNPYMALAKVMELFDKSPRPDGKIHSKAVIAASAIIGENVTIGANAVVGENVVIGDNVYIGACATIDNGTKIGNDTLIKSNVSIAHDVVIGTGCIIHQNAVIGCDGFGNARDEDGSWTKIPQLGRVIIEDDVEIGSGTTVDRGAIDDTIIKKGARIDNLVQIAHNVVIGRNTALAGVTAVAGSTTIGDNCLIGGQSAITGHISICDNTIIGGASNIGKSITKPGMYYAAFEAKPRIQWGRFVAKLAKIDTLITKVKQLEEKIK
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: FLGM_YERE8
Sequence: MSIDRTQPLLPVTPVQPRETSDIAQQTRKPSAQSKTPVSGTEVKLSDAQAKLMQPGSQDINVERVETLKQAIRSGQLTMDTGKIADALLKNVADDLKNS
What is the function of this protein?
Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective.  It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA (By similarity).
What are the official names of this protein?
Negative regulator of flagellin synthesis, Anti-sigma-28 factor.
What is the protein family that this protein belongs to?
Belongs to the FlgM family.
Protein: MED14_DROME
Sequence: MAPTPLPLEQMPGVGGGGGGYLPAAQEGGPRINTMSMSVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPIMEEMQDCLNGDRSKLPALLSELRFWITHRRCDKTLQHLPATATETLPFLVQPDQEILQPGRHKIYVKLHRHPNIVLVVQLKEKTTMPNEMEYTFHLGFVAYQKDELDVIDDSAMQLVSIVAQPHSDIPKCYTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFATQQQQQQGAPAVAGENKPSGTSGLPKIDSHVWDDLMRRVLSISIRSQTNKNSQVRIWVVEFVFYSTPLQSSHPKEQGSRRTVYLTYEQANYDFSKTVEDLLNDWSKIVYLYTLVYDFAEQLLNKRLSLCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNGHSMMRDQLAQHLNQQHSITQIAQILHETYNPLSSIAKLPVLPFLGIPRPQVPVLSFCVLAQSPCLIRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVVEEFTPIQGLKAFLSKYVDESAVYRGRASHEDDNPLSPMGMEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAGGGSGPQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPDHKSTGGGAGVAGGTDRGGSRGTLNRPWAGAVPTLLTHEALETLCRPSPYPNKDINVPDMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVVLNQMHMQTLHLKVSQLPPMPDKHPPPFQLSQDDLLVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLDLKPELGGDQLKWTVQICLRMPPSAVPIVPSGNACVVMGRMKILFFLQITRIPYGAVIGVGKDWKDSPSLVLPIVYDIQTNVTQLAERTGQVISPTMTAASTLLRRFAEFNAQQNQCTLFPAITDLLTNLQLAAEMPQPPPNQSIGPPVGVGVGVGSSPNPMMPMQQLPQQVGPQGPVGPGGYPQMGPNPGGPQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.  Required for activated transcription of the MtnA, MtnB and MtnD genes.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14, dRGR1.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IHFA_METCA
Sequence: MALTKADMVERLFSELGLNKRDAKELVDQFFEVIKASLESGRSVKLSGFGNFDLRDKRQRPGRNPKTGEEIPITARRVVTFKAGQKLKATVEALQEPELGKLDAERTGEV
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: NUOD_WOLPP
Sequence: MPDLKTMMLNFGPQHPAAHGVLRLVLEMDGEVIERADPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVSPMSQEHAYSLCVEKLLQCEIPIRAKYLRVLFCELTRILNHLLNISSQALDVGAMTPLLWLFEEREKILEFYERASGARFHAAYIRPGGLAADIPEGLIEDIAKFIEQFPKYIDDVDELLTENRIWKQRTVGISEISIKQALDWGFSGPMLRAAGLAWDLRKSQPYEIYDQLDFDIPIGQNGDCYDRYLVRMAEIRQSVSLVKQCIEKMPEGPIKTEDRKISPPPRAEMKESMEAMIHHFKLYSEGYHVPEGEAYVAVEAPKGEFGVYIVSDGTNRPYRCRIRAPGFAHLQALDFMAKGHMLADIAAIIGSLDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GP16_BPLSK
Sequence: MLEANVYDNFNPNYYNVSDFSMPNGKKEKRGLPIPKARCQVINYELWETGYLYTSSATLTVSVEVGDIVQILFPEVVPIEEALGKKKKLNLDMVYLVTDVDESNKATLKNYFWAMIESLDVPNAITKTTNFAIIDYLIDPSKNNLMSYGYFFNSSIFAGKATINRKAETSSAHDVAKRIFSKVQFQPTTTIQHAPSETDPRNLLFINFASRNWNRKRITTRVDIKQSVTMDTETIVERSAYNFAVVFVKNKATDDYTDPPKMYIAKNNGDVIDYSTYHGDGTDLPDVRTAKTLFYDRDDHGNPPALSTIKVEISPSTIVTRLIFNQNELLPLYVNDLVDIWYEGKLYSGYIADRVKTEFNDRLIFVESGDKPNVI
What is the function of this protein?
Forms a dome thereby closing the central channel at the end of the baseplate.  Changes its conformation upon activation by calcium allowing the channel to open at the bottom of the baseplate for DNA ejection.
What are the official names of this protein?
Baseplate protein gp16, Exolysin, Gene product 16, Gp16, Tail lysozyme-like, Tail-associated lysine-like protein.
What is the protein family that this protein belongs to?
Belongs to the skunalikevirus baseplate protein gp16 family.
What are the subcellular locations of this protein?
Virion. Note=Part of the baseplate.
Protein: CER1_XENTR
Sequence: MLLCVLKIYIIFCLVNDGAGKRSEVRGRTKTYSHNSRGYFRKERGMGKNKILLVNTKGFDQPHIGQGSFGLVAELFDSTRTDTSRKEPDINKVKLFSTAAHANKSSRNIGIFRRKAFNGSRRNIFSRQPFNKRNTDVTEKPGAKMFWNNFLVKMNGAPQNTSHGGKPQEIMKEACKTLPFTQNIVHENCDRMVIQNNLCFGKCISLHVPNQQDRRNTCAHCLPSKFTLNHLALNCTGSNNVVKVVMMVEECACEAHKNNYHQTAQFNMDASTTLHN
What is the function of this protein?
Inhibits wnt, nodal/nr-1 and bmp signaling in the embryo to promote head formation and anterior neural induction.  Within the endoderm, acts as an essential mediator of nodal/nr-1-induced cardiogenesis in the overlying mesoderm (By similarity).
What are the official names of this protein?
Cerberus, Cer, tCerberus.
What is the protein family that this protein belongs to?
Belongs to the DAN family.
What are the subcellular locations of this protein?
Secreted.
Protein: IL18_PIG
Sequence: MAAEPEDNCISFVEMKFINNTLYFVAENDEDLESDYFGKLEPKLSIIRNLNDQVLFINQGHQAVFEDMPDSDCSDNAPQTVFIIYMYKDSLTRGLAVTISVQCKKMSTLSCKNKTLSFKEMSPPDNIDDEGNDIIFFQRSVPGHDDKIQFESSLYKGYFLACKKENDLFKLILKEKDECGDKSIMFTVQNKN
What is the function of this protein?
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses.  Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-18, IL-18, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: GRIA1_MACFA
Sequence: MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASSAGSGENGRVVSHDFPKSMQSIPCMSHSSGMPLGATGL
What is the function of this protein?
Ionotropic glutamate receptor.  L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.  Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.  The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.  In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
What are the official names of this protein?
Glutamate receptor 1, GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Presynapse. Synapse. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity).
Protein: WSD6_ARATH
Sequence: MEIKTRRDTSETSVRKDDEEEVEEEQPLSPAARVFHAPEFNCYVISVIGIKKKIDPDVIIEGLKQTLIRHPRFSSKMVSTSVGNKKRQTQSWVRTNVVVTDHVIVSDIQTQNIENGNADAFLETYVSNLTTVPLDISKPLWQLHLLDLKTSDAENVAVLKFHHSLGDGMSLMALVLACMRKTSNPDELPSLPNQNRSSSRSSRLMAGSRGDSRFLWLVMVIWSAIMLVLNTVCDALEFIATTMFLKDTETPIKGDFRFSKSKRMCLVHRTVSLDDIKLIKNTMKMTVNDVVLGVSQAGLSQYLDRRYGEKKKKVGEDQDSKRKATDMPKRIRLRSALLVNLRPNTGIQDLADMMAKGSTCRWGNWIGYIVFPFSIGLRDDPLQHLRRAKRIIDRKKNSLEAALTFVAGKFILKTFGVQVAAKIINRALSNTTMSFSNLIGPIEEISFYGHPITYMAPSVYGHPHALTMHFQSYMNQMTISLTVDPTVISDPHRLLDDWEKSLQSIKAAVQERDSRSLD
What is the function of this protein?
Bifunctional wax ester synthase/diacylglycerol acyltransferase that uses acyl-CoAs with 16, 18 and 20 carbons as substrates, preferably in combination with 16:0ol alcohol (PubMed:30729606).  Involved in cuticular wax biosynthesis (By similarity).
What are the official names of this protein?
Wax ester synthase/diacylglycerol acyltransferase 6, WS/DGAT 6, Diacylglycerol O-acyltransferase WSD6, Long-chain-alcohol O-fatty-acyltransferase WSD6.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the long-chain O-acyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Protein: URK_HAEI8
Sequence: MSNPSCIIIAITGASASGKSSIASTVHKELCNELGCQEIGIITEDSYYKDQSHLEMTERVKTNYDHPNSMDRDLLIQHLKNLKNGSAVDVPVYSYVEHTRTNETTHFTPKRIVILEGILLLTDERVRQLADISVFVDTPLDICFIRRLQRDMEERGRSLQSVIDQYRATVRPMFLQFIEPSKQYADIVIPRGGKNRIAINMLKAQILHLLNQK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_AQUAE
Sequence: MNVELFKKFSEKVEEIIEAGRILHSRGWVPATSGNISAKVSEEYIAITASGKHKGKLTPEDILLIDYEGRPVGGGKPSAETLLHTTVYKLFPEVNAVVHTHSPNATVISIVEKKDFVELEDYELLKAFPDIHTHEVKIKIPIFPNEQNIPLLAKEVENYFKTSEDKYGFLIRGHGLYTWGRSMEEALIHTEALEFIFECELKLLSFHS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: GUAA_VIBVU
Sequence: MTKNIHDQRILILDFGSQYTQLVARRVREIGVYCELWSWDVEEADIREFNPDGIILSGGPESVTEDNSPRAPQYVFDSGVPVLGVCYGMQTMAEQLGGKVSTSDEREFGYAAVKVSGESAIFKDLEATQDVWMSHGDKVVEIPAGFTKVGETDTCPYAAMANEEKKYYGVQFHPEVTHTKNGLQMLENFVLGICGCERLWTSESIIEDAVARIKEQVGDDEVILGLSGGVDSSVVAMLVHRAIGDKLTCVFVDNGLLRLNEGQQVMDMFGDKFGLNIIKVDAEERFLKALEGKSDPEEKRKTIGHVFVDVFDEESKKLKNAKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYEMLYRHPFPGPGLGVRVLGEIKKEYCDLLRRADAIFIEELHAADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PHAG_PSEOL
Sequence: MRPEIAVLDIQGQYRVYTGFYRADAAENTIILINGSLATTASFAQTVRNLHPQFNVVLFDQPYAGKSKPHNRQERFISKETEAHILLELIEHFQADHVMSFSWGGASTLLALAHQPRGVKKAVVSSFSPVINEPMRDYLDRGCQYLAACDRYQVGNLVNDTIGKHLPSLFKRFNYRHVSSLDSHEYAQMHFHINEVLQHDLERALDGARNIDIPVLFINGDRDEYTTVEDARQFSKHVGRSHFSVIRDAGHFLDMENKTACEDTRSVMLGFLKPTMREPRHRYQPVKQGQHALAI
What is the function of this protein?
Catalyzes the transfer of the acyl moiety from in vitro synthesized 3-hydroxydecanoyl-CoA to acyl carrier protein.
What are the official names of this protein?
(R)-3-hydroxydecanoyl-ACP:CoA transacylase, 3-hydroxyacyl-CoA-acyl carrier protein transferase.
Protein: HBB_CAMBA
Sequence: MVHLSGDEKNAVHGLWSKVKVDEVGGEALGRLLVVYPWTRRFFESFGDLSTADAVMNNPKVKAHGSKVLNSFGDGLNHLDNLKGTYAKLSELHCDKLHVDPENFRLLGNVLVVVLARHFGKEFTPDLQAAYQKVVAGVANALAHRYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.