PharMolix/UniProtQA huggingface dataset:
Protein: T11L1_MOUSE
Sequence: MSENLDKSHVDEAGEAEAAASEQGLEGALECSDETLQKKVKSDSPSSQRVGRPHSSPARLVTVEELLETAKGVTNMALAHEIVVTGDFRINAVELAEGSLEKRVKEIVHKAFWDCLSVQLSEEPPTYDHAIKLVGEIKETLLSFLLPGHTRLRNQITEVLDLELIKQEAENGALDISKLAEFIIGMMGILCAPARDEEVKKLKGIKEIVPLFRAIFSVLDLMKVDMANFAISSIRPHLMQQSVEYERRKFQEVLERQPNSLDFATQWLEEATNDLLSQKYKHALPAGGGAAGSGDAPLLTPVSVQNFAYLKLLKWDHFQRPFPETVLMDQSRFQELQLQLEQLAVLGAVLLVTFSTAAPGISGHADFAEKLKMMVKTLLTDMHLPSFHLEDALASIGEKVCLEVSSCLSLCGSSPFSVAKETVLKGQIQALASPEDPIRRIMESRIFTFLETYLASGHQKPLPTVPGGLGPIQKELEEVAVKFVRLVNYNKMVFCPYYDAILSKLLLRS
What are the official names of this protein?
T-complex protein 11-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the TCP11 family.
Protein: DAPF_METSB
Sequence: MNPLANRLAVKMNGIGNEILIVDLRGAGAGVTGPQARAIARTKGLAFDQLMVLEDPRSKGCAAFVTIFNADGSQSAACGNGTRCVAWTLLKDGARDEVLLETAAGRLACRRVSELVFSVEMGRPRLKAAEIPLSRDAPDTSAVDLSFGPADSPILKNPAVVNMGNPHAIFFVEDIGAYDLAAIGPVLEHDPLFPERANISLARIVSPERIELKVWERGVGLTLACGSAACAALVAAARRGLTGRRATVALPGGELDIFWRESDDMVVMTGPVAFEFETRLDPAIFADAAA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_BACTN
Sequence: MLLSVLLQATAAAVGVSKLGAAIGAGLAVIGAGLGIGKIGGSAMEAIARQPEASGDIRMNMIIAAALIEGVALLAVVVCLLVFFL
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OSBL9_XENTR
Sequence: MASIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTITVDQKTFHFQARDADEREKWIHALEETILRHTLQIQQGLDSGFVPSVQDFDKKLAESDAYLQILIDQIKLFDDKIQSCKDDEQRKKIEDLKDTTCSMVESIKHCIVLLQIAKDQTNEEKHADGFISTINPVDSIYQPSALESVVIPTMPTQASPVPESVQVCKGEPRPSSLAVGPVVSNLGSRQSPTPISTGSGQSAPSSSLTSPSHVNLSPNTVPDFSYSSSEDEFYDADEFYQSSTSPKRCMDSSESATALTHSSTGASLKRPDTTESLNSSMSNGTNEAEQFDTHDDRDDDGEGESVEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSIGEHKDPKDRMAQVVKWYLSAFHAGRKGSVAKKPYNPILGEVFQCHWALPGLENDENPEAVSEGPIPWASKNNVTFVAEQVSHHPPISAFYAECYNKRIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGYGRSILTVPWVELGGECTINCSKTGYNATITFHTKPFYGGKKHRVTAEIYSPNDKKPFCSIEGEWNGIMYAKNANGENTVFIDTKKMPTVKKKVRKLEDQEEYESRRMWKDVTFNLKIKDIDAATEAKHRLEEKQRAEARERKEKEKQWETRLFHEDGECWVYDEPLLKREPSLRY
What are the official names of this protein?
Oxysterol-binding protein-related protein 9.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: Y5270_ARATH
Sequence: MVVEKQTKYEEFRLKRVEENKKRMEALNLPKLSQILNSTSVKISPMKKRSIPRTPEKKMVDVKRVHIQRRGVGKKRDLLNRVYVSEEIRDEAISRANKFQDELGSGYPSFVKSMLQSHVSGGFWLGLPVQFCKSHLGLHDGVITLIDEEGEEYETIYLARKNGLSGGWMGFAVAHNLAYGDTLVFELVRRTAFKVYITRVGSCGESSKDMS
What are the official names of this protein?
B3 domain-containing protein At5g42700.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y423_MYCPN
Sequence: MKPQLLALKQFVQTEFEKVDFETFRQNFNRCLEREQSTLLIYEDDDYDDQSFFLKPMLSDAFFISSEVVKQLDLLAVLVDNPKGDVKSCCQSFYEALTLFISALAITKGVDVGRYHQQLGKRFGVLTVY
What are the official names of this protein?
Uncharacterized protein MG296 homolog.
Protein: DCIP_AZOBR
Sequence: MKLAEALLRALKDRGAQAMFGIPGDFALPFFKVAEETQILPLHTLSHEPAVGFAADAAARYSSTLGVAAVTYGAGAFNMVNAVAGAYAEKSPVVVISGAPGTTEGNAGLLLHHQGRTLDTQFQVFKEITVAQARLDDPAKAPAEIARVLGAARALSRPVYLEIPRNMVNAEVEPVGDDPAWPVDRDALAACADEVLAAMRSATSPVLMVCVEVRRYGLEAKVAELAQRLGVPVVTTFMGRGLLADAPTPPLGTYIGVAGDAEITRLVEESDGLFLLGAILSDTNFAVSQRKIDLRKTIHAFDRAVTLGYHTYADIPLAGLVDALLEGLPPSDRTTRGKEPHAYPTGLQADGEPIAPMDIARAVNDRVRAGQEPLLIAADMGDCLFTAMDMIDAGLMAPGYYAGMGFGVPAGIGAQCVSGGKRILTVVGDGAFQMTGWELGNCRRLGIDPIVILFNNASWEMLRTFQPESAFNDLDDWRFADMAAGMGGDGVRVRTRAELKAALDKAFATRGRFQLIEAMIPRGVLSDTLARFVQGQKRLHAAPRE
What are the official names of this protein?
Indole-3-pyruvate decarboxylase, Indolepyruvate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: YL715_MIMIV
Sequence: MVGANIYNTHNIHDPNNLNNLNNINNPNNITNNMHNPHNIFQNNYFDPKQLKILVDNMTPQDLELLLTLSCKKGIIRDVEYILCRIMREMINININYGLCQAIENYHLKIVELLIDHGADINYNNGLPLNLAVKNGYYDIIELLIEKKVNTNDNIFQLLTHCCQNNLPNSLRILLKENISIDPIYSTMVNLCLDNGYAECASILINHNNSDSTINSESMIHDTNLTTSQTLLELDDLLELDDLLDGNDYFNYNQDESDVGDDAENDIENDIEDDN
What are the official names of this protein?
Putative ankyrin repeat protein L715.
Protein: HIS8_LEUMM
Sequence: MKKTVKALAAYQAELPVETVKAKYGLQHLARLSANESVYGPSPKVAQAVRAVSDDILGYYPDGQATELREAVAKLNHVDPQHLVFGAGADELIELLTRVVLEPGSNIIIPNPTFGEYAMHAQIEQSTTKKIPVNVDNGNVDFDAILDAIDDKTAMVWIANPNNPTGVFETTSSIKRFLDKLPANITLVVDEAYYDFVDEPDATVAPLVAEYTNLVVLRTLSKAYGLANLRVGYGIMQDPLYSAMQAVRLPYNLSTYQIAGGTAAVLDQEYLQKNVQRFQVERQKFQDFLTKNKFKFYESQANFIWIKVGETKKVGQKLLEQGFQVNDRLNPEWIRIALGTPEDNAELKLAFLKATNK
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: GCST_STAA3
Sequence: MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNLTTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQLVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLHGQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSPSSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: PEPT_STRR6
Sequence: MTYPNLLDRFLTYVKVNTRSDEHSTTTPSTQSQVDFATNVLIPEMKRVGLQNVYYLPNGFAIGTLPANDPSLTRKIGFISHMDTADFNAEGVNPQVIENYDGCVIELGNSGFKLDPADFKSLEKYPGQTLITTDGTTLLGADDKSGIAEIMTAIEYLTAHPEIKHCEIRVGFGPDEEIGVGANKFDAEDFDVDFAYTVDGGPLGELQYETFSAAGAELHFQGRNVHPGTAKGQMVNALQLAIDFHNQLPENDRPELTEGYQGFYHLMDVTGSVEEARASYIIRDFEKDAFEARKASMQSIADKMNEELGSNRVTLNLTDQYYNMKEVIEKDMTPITIAKAVMEDLGITPIIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEYVSLQTMERAVDTIIGIVRSL
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLTF_ECO24
Sequence: MKKLKINYLFIGILALLLAVALWPSIPWFGKADNRIAAIQARGELRVSTIHTPLTYNEINGKPFGLDYELAKQFADYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYNSERVKNYQPGPTYYSVSQQLVYKVGQYRPRTLGNLTAEQLTVAPGHVVVNDLQTLKDTKFPELSWKVDDKKGSAELMEDVIEGKLDYTIADSVAISLFQRVHPELAVALDITDEQPVTWFSPLDGDNTLSAALLDFFNEMNEDGTLARIEEKYLGHGDDFDYVDTRTFLRAVDAVLPQLKPLFEKYAEEIDWRLLAAIAYQESHWDAQATSPTGVRGMMMLTKNTAQSLGITDRTDAEQSISGGVRYLQDMMSKVPESVPENERIWFALAAYNMGYAHMLDARALTAKTKGNPDSWADVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQATEAAMQLAQDYPAVSPTELGKEKFPFLSFLSQSSSNYLTHSPSLLFSRKGSEEKQN
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: NSRR_ENT38
Sequence: MQLTSFTDYGLRALIYMASLPQGQMTSISQVTEVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKPAQSIRVGDVVRELEPLSLVNCSSDFCHITPACRLKQALSKAVQSFLMELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: MINC_PSESM
Sequence: MSQIESPNPEPVFQLKGSMLAITVMELARSNLEALDRQLAAKVAQAPNFFSNTPLILALDKLAPNEGPVDLPGLVRICRQHGLRTLAIRANRIEDIAAAIAVDLPVLPPSGARERVIDPIEAEAPKKLPEKPPEPLIKPTRVITSPVRGGQQIYAQGGDLVVVAPVSPGAELLADGNIHVYGPMRGRALAGIKGDTKARIFCQQLSAELISIAGQYKVSEDLRRDPLWGSPVQVSLSGDVLNIIRL
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: MURA_VIBC1
Sequence: MEKFRVIGSDKPLVGEVTISGAKNAALPILFASILAEEPVEVANVPHLRDIDTTMELLKRLGAKVSRNGSVHVDPSSINEYCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHITGLEQLGATITLEDGYVKAEVDGRLKGAHIVMDKVSVGATITIMCAAALAEGTTTLDNAAREPEIVDTADFLNTLGAKISGAGTDTITIEGVERLGGGKHNVVADRIETGTFLVAAAVSGGKVVCRNTNAHLLEAVLAKLEEAGALVETGEDWISVDMTDRELKAVSIRTAPHPGFPTDMQAQFTLLNMMAKGGGVITETIFENRFMHVPELMRMGAKAEIEGNTVICGDVDSLSGAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGYDKIENKLSALGANIERVSEAG
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_NANEQ
Sequence: MILPPRGTKDFTPELAILWKEIVSKIESVYQKYGFDPIITPIVEYWDTLKGKYGEEAEKKEIWRFRVPQSKKWYALKYDQTVPLARYFARFRPKLPFKRYTIDRTFRYDEPQKGRYREFWQADADIVGSPYPEADAEILNMMIEAYETLGFNVYLRVSDRRALESLIEKVGEKDKFIEIARIIDKWDKIGEEGVLEKLKQITDKAEKIIELLKENPEEFYPKEFWEIIDLVEKKNKIKIDIKLARGFDYYTGMVYEVWIEGFNRALGGGGRYDNLIGIFSKEKIPAVGGSIGINPLIDVGLEKGIFNLNKKTYTQIAVIYIEVFKEAWRIANKLRDLGLNVYIDLLRRDFKKQMEYVIEKDIRYLVIVGKKDLANNLVTFQDRLTRERKKIPIENLEEIKSLVQ
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARO1_VERA1
Sequence: MSCSNNTEPTRIAILGTDNIVVDHGIWLNWVTKDLFDNVKSSTYVLVTDTNLYDTYVPPFKHAFDGATDTTAGPRLLTLAIPPGEISKSRQSKAHIEDWMLSQQCTRDTVIIALGGGVIGDMLGYVAATFMRGIRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLVGAFWQPSRIYIDLAFLETLPSREFINGMAEVIKTAAIWDENEFATLEANAPSIVAAVNQPTGPGRLSPIREILKRIVLGSARVKAEVVSSDEREGGLRNLLNFGHSIGHAYEALLTPQLLHGEAVAIGMVKEAELARYLGVLRPSAVARLAKCISSYGLPTSLGDKRVIKLTAGKRCPVDILLQKMAVDKKNDGRKKKIVLLSAIGKTHEPRATTVEDAAIKVMLSASTLITPGVSTKLATTVTPPGSKSISNRALILAALGEGTCRIKNLLHSDDVEFMLTAITRLGGASYAWEDAGEVLVLTGKGGQLRASSDPLYLGNAGTASRFLTTVVALCSPADVSSTVLTGNARMQVRPIGPLVDALRSNGVSIDYLGPGKSLPLRIDAAGGFAGGVIELAATVSSQYVSSILMAAPYAKEPVTLRLVGGKPISQPYIDMTLAMMKTFGVQVERSSSDPNTYHIAKGTYKNPAEYTIESDASSATYPLAIAAITGTTCTVPNIGSSSLQGDARFAIDVLQPMGCTVQQTASSTTVTGPAPGGLLGLPHVDMEPMTDAFLTASVLAAVAAGTTKISGIANQRVKECNRIAAMREQLGKFGIATDEFDDGIIVTGQPLDTLKTPDAGVFCYDDHRVAMSFSVLSTVANAPVTILERECTGKTWPGWWDTLSQSFGLRLNGDDKHPGVEGRHQQDHTTRSVFIVGMRGAGKTTTGRWMAKLLKRPFIDLDEELERRSGMTIPEMIHGTKGWEGFRRDELQLLHDVMENQASGHVFSCGGGIVESPEARKLLIAYKEKGGCVLLVHRDTKQVVDYLLQDKTRPAYREDIEDVYYRRKPLYDECSNFQYFSPHPAASVASRDAPLDFRCFVDAICGDGSKVTKMTAKEQSFFVSLTVPSVDSAVDVIPQVVVGSDAVELRVDLLQDQTPESVARQVSALRSAAGMPIIFTLRTVSQGGCFPDADHTQALSLYILALRMGVEFIDLEMTWPEHILQTVTNLKGRSRIIASHHDPRGELSWKNGSWTPFYNRALQWGSVIKLVGTAQSMEDNYDLARFKSDMLASHPTPVIALNMGALGKLSRVLNGFLTPVSHPALPFKAAPGQLSAAEIRRALFLLGNINAQSFHLFGKPISKSRSPALHNSLFNLTGLPHKYGLVETDQADEVAAVIREPDFGGASVTIPLKLDVMPLLDEVSESAKVIGAVNTIIPMPLDGSQKRRLLGDNTDWRGMVHCLESIGVASESTASTTTASALVIGSGGTTRAAIFALKSHGYHPIYMLARNEQSLETIRASFPTDFDLRALGGPAEVFTLAVAPTVVISTIPADKPMDPSLRETLEVVLKSPVSEQRTRVLLEMAYQPRHTAAMRLAEDAGWRTIPGAEVLAAQGWHQFQMWTGITPRFIDAQAAVNGDEIPTSTD
What is the function of this protein?
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
What are the official names of this protein?
Pentafunctional AROM polypeptide.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the shikimate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_VIBPA
Sequence: MSYDQAVLNRIWSETILTELHRFGVKHVCIAPGSRSTPLTLEAAEQPNFSIHTHFDERGLGFMALGLAKASQEPVAVIVTSGTAVANLLPAVAEAKLTGEKLVLLTADRPVELVGCGANQAINQLGIFSQHVSANLNLPSPSLNTPLNWLLTSVDEVMFNQQLHGSAVHINCAFPEPLYSDGEKSAYQSYLSSVEAWRKGGQTYTQRFVSPSFRDIPFCADRKGVVVIGSLSAEHAQEAKAFAQQMGWPVLADPQSGVSSDWSHYDLWLQQPKLASQLDECDLVLQFGSRIISKRLNQWINKQVSQSQQGRDVQYWFISPSLSRDNQTHLPQLHWVASPKSWVERVDVKSSSTQGWADGLLTDIAHVRAHISDEFLFSSASTLNEIALAADIEERTQSVDVFLGNSLFVRLVDMFGRLNTEVFTNRGASGIDGLFATASGVQRSRGKPLLMYIGDTSALYDLNSLALFSRNDLPSVLVVTNNDGGAIFDMLPVPQEHRTAYYQMPHGYQFEHAAKQFGLKYEKPTTLQMYQAMVADHLSSGQGTMLVEVQTPPSQAAELIKAFNKSLHASL
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: THIL_BUCAP
Sequence: MEYNEFEIISKFFKNHQKKDKNQIKGIGDDSALIKIPKNNLLAISTDTLVEGKHFLKNITPKDLAYKSVAVNLSDLAAMGAKPTWITLSITMPKSDSVWLKSFSKSFFKILNKYKLNLIGGDTNSGPLSITLSIYGLIEGKNALLRGNAKNGDLIYITGNLGESAAGLSLLQKKTFLKNVKICNYLIKKHLKPIPRISEGIALRNIANAAIDISDGLISDLGHILKNSKCGADINLNTIPISKILTDNFKIDEYLNWALNSGEDYELCFTISKKNIKKLNVAIKKKIIKCTCIGYITSAEKGLNLIQNQKKIIFKKSGFNHFI
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
What are the official names of this protein?
Thiamine-monophosphate kinase, TMP kinase, Thiamine-phosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-monophosphate kinase family.
Protein: THIC_ACIF2
Sequence: MATRPTDMVNTMQDAAVTCGPIPGSHKRYLGGVRFPELRIPLREIRQSDSRKRDGSLEVNPAIPVYDCSGPYTDPDVVIDIHAGLPAMRWQWSPTDTAIESRPEPGSAYGRARLADVRTADLRFHHRREIRRAANGGNVSQMHYARRGIITPEMEFVAIRENQGLEHLRASHPALFRAHRGESFGAQIPDTITPEFVRDEIARGRAIIPANINHPELEPMIIGRNFLVKINANIGNSAVTSSIAEEVEKMVWSIRWGADTVMDLSTGRHIHETREWIIRNSPVPIGTVPIYQALEKVDGKAEDLTWDLFRDTLIEQAEQGVDYFTIHAGVLLRYIPLTANRLTGIVSRGGSIMAKWCLAHHQESFLYTHFEEICEIMKAYDVSFSLGDGLRPGSLADANDEAQFAELHTLGELTRIAWKHDVQVMIEGPGHVPMQLIKANMEEELQHCFEAPFYTLGPLTTDIAPGYDHITSAIGAAQIGWYGTAMLCYVTPKEHLGLPDKNDVREGAITYKIAAHAADLAKGHPGAQVRDNALSKARFEFRWEDQFHLGLDPEKAREYHDETLPQEGAKAAHFCSMCGPHFCSMKISQDLQEYAQSKGEDIETARLEGLQEKAEDFKRLGKNIYLR
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: SSPI_BACCQ
Sequence: MSFNLRGAVLANVSGNTQDQLQETIVDAIQSGEEKMLPGLGVLFEVIWKNADENEKHEMLETLEQGLKK
What are the official names of this protein?
Small, acid-soluble spore protein I, SASP I.
What is the protein family that this protein belongs to?
Belongs to the SspI family.
What are the subcellular locations of this protein?
Spore core.
Protein: REV_HV1OY
Sequence: MAGRSGDSDEELLKTVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIRKISGWILSTYLGRSAEPVPLQLPPLERLNLDCSEDCGTSGTQGVGSPEILVESPAVLEPGTKE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: HEMH_BURO1
Sequence: MRFDLEPPSSVAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALTQFKRAGVERVLLMPMYPQYSASTTATAFDAAFDALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMAALGLSTTECHVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGKTFHRIPCLNGASAWIGALSEIVAENLQGWPVKAAQPEPVN
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
Protein: PUP_BIFLS
Sequence: MPQQFEQPQAQQAVTQEDDALATTQAATQTESTDQADVLDDILDDIESTLETNAEEYVNSFVQKGGE
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: NKX23_HUMAN
Sequence: MMLPSPVTSTPFSVKDILNLEQQHQHFHGAHLQADLEHHFHSAPCMLAAAEGTQFSDGGEEDEEDEGEKLSYLNSLAAADGHGDSGLCPQGYVHTVLRDSCSEPKEHEEEPEVVRDRSQKSCQLKKSLETAGDCKAAEESERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGAHAPPPPPRRVAVPVLVRDGKPCVTPSAQAYGAPYSVGASAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPAGGGGGGGGTSAATTAMQPACSAAGGGPFVNVSNLGGFGSGGSAQPLHQGTAAGAACAQGTLQGIRAW
What is the function of this protein?
Transcription factor.
What are the official names of this protein?
Homeobox protein Nkx-2.3, Homeobox protein NK-2 homolog C.
What is the protein family that this protein belongs to?
Belongs to the NK-2 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OPSD_COMDY
Sequence: YLVNPAAYAALGAYMFLLILIGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVLGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIALWSLVVLAIERWIVVCKPISNFRFTEDHAIMGLAFSWVMALSCSVPPLVGWSRYIPEAMQCSCGVDYYTRAEGFNTESFVLYMFTVHFLIPLSVIFFCYGRLLCAVKEAAAAQQESETTQRSEKEVSRMVVLMVIGFLVCWLPYASTAWWIFCNQGSEFGPVFMTIPAFFAKSSAIYNPMIYICMNKQFRHCMI
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: DSBB_PHOPR
Sequence: MQFLNTFSKSRISWLLLLLCIVFFEGSALFFQHGMKLGPCVMCIYERVAMMGIAFAALLGAIAPQYAIIRWAGLIAWGYSAVRGLQLSIEHVGYQFNPSPFATCDLFVQFPNWAPLNKWVPWMFEAYGNCAEVVWTFLGQSMPQWLVIIFAGNLVALALIVIAQFFSKKTNTILDM
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ERGI1_MOUSE
Sequence: MPFDFRRFDIYRKVPKDLTQPTYTGAIISICCCLFILFLFLSELTGFITTEVVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGAGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHTIHKLSFGDTLQVQNVHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQRYSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILDSCIFTASEAWKKIQLGKIH
What is the function of this protein?
Possible role in transport between endoplasmic reticulum and Golgi.
What are the official names of this protein?
Endoplasmic reticulum-Golgi intermediate compartment protein 1, ER-Golgi intermediate compartment 32 kDa protein, ERGIC-32.
What is the protein family that this protein belongs to?
Belongs to the ERGIC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi- pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.