PharMolix/UniProtQA huggingface dataset:
Protein: SYM_METKA
Sequence: MGKVLVTTALAYTNGPLHIGHVRSTYLPADVYTRFLKMRGIDAIHIGGTDNHGVPIALQAELEGKDPEEIVEKYHEMIKEDLERLNIHFDEFSCTCREFNPDHVDMTQWFFKRLYEAGYIEEREVEQLYCPECERPLPDRYVEGVCPYCGAEGARGDHCEACGRYLEPVQLEEPRCVICGSKPEVRRTMHLFFKLSEFEEDLKKWLESNDNLPKNVRNYAIQWVREGLKDWDIVRDLDWGVPVPLEGYEDKVFYVWFDAPIGYVTFTKQYCDRVGQDWKDYWFSEDTKIVHFIGKDIIVHHALFWPAMLMGVGATLPYTIVAGEYLTLEGEKMSTSRGWVVWVKDFTKLFPADLLRYYLIVVSPLTRDADFSWGDFRDRVNNELVANLGNFVYRTLSFIYRFLDGNVPEAETDQEIVDKIKETHQRVTEHLEKFRFREALTEVLRLSKFGNEYFQEHEPWKLKDEDPERCAEVLRGCARIVKALAVMLAPFLPDSAEKIWQSLGYEDSVHDVDWEEALEDVETKEIPEPEPIFPKVTEEDLEKAKALLPEESGESEGQDDEYVSLEEFNRLDLRVGKIKEAERVEGSDRLIKLRIDIGDRTVTAVAGLYPTYEPEELVGRKVVVLANIQPKEMFGVRSEAMILAVGDEPALLTIDESKREVEPGERIR
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCYA_SYNSC
Sequence: MQPKPLAPPPGQHPLVQALAASIRSAWAGLPGLEILPCDEDLRFIQGQLDGEGLSIGNELFRCIGLRKLHLEVARLGNGLQILHSVWFPDPHYDLPIFGADIVAGPAGISAAIVDLSPTSDALPEQLIQRLEARPWPAFRQVRELPAWGSAIFSNKVCFIRPDGADEEAAFQQLVSHYLQVMATSVIEATPEQSTALTTVRRYEGQLNYCLQQKRNDKTRRVLEKAFDSAWADRYIDMLLFDNPPEL
What is the function of this protein?
Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.
What are the official names of this protein?
Phycocyanobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: Y495_TREPA
Sequence: MLLMRLAVPFCRQNAVSSYLALSPLPKGGIFSVALAVSGTAESRCLVIN
What are the official names of this protein?
Uncharacterized protein TP_0495.
Protein: NUSB_XYLFM
Sequence: MSKVSGGGPCPRRRDGVDPALRSRARRRALQAVYAWQISGGVAKQVIAHFAHEQAYEVADLVYFEDLVEGVLTHCAELDEKLTPYLDRTIEEVDAIERAVLRLGAYELLYRQDVPYRVVINEAIMTAKRFGSKYGHTYVNGVLDRAALALRKVEVLG
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PUR9_LISW6
Sequence: MKRALISVSDKNGIVPFAEKLVELGVEIISTGGTKATFEQAGIPVTGIEDVTKFPEMLDGRVKTLHPAIHGGLLARRDTAEHMEAIAAHDIEPIDLVVVNLYPFQETIQKPGVTLEEAIENIDIGGPSMLRSAAKNYAAVTVVVDAADYDTVLTELKEHGATTFETRQRLAAKVFRHTAAYDAVIAEYLTKITGETFPEKVTFTYNRKQALRYGENPHQDAAFYTEPVALLNSISAAKQLHGKELSYNNIRDADAALKIANEFTEPVAVAVKHMNPCGVGVGENIEEAYLKAYEADETSIFGGIVALNKEVDAKTAEHMSKIFLEIIIAPSFSEEAFTILAKKKNIRLLTVPFAGSVESLEKTSVNGGLLIQASDSFVEDSAGYEVVTEKQPTEAEMKALLAQWKIVKHVKSNAIVVGSDKQTLGIGAGQMNRIGSALIALEQAGEKAKGAVLASDAFFPMDDTVEAAAKAGITAIIQPGGSIKDKESIAMADKYGISMVLTHVRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: B3GTI_ARATH
Sequence: MKKPKLSKVEKIDKIDLFSSLWKQRSVRVIMAIGFLYLVIVSVEIPLVFKSWSSSSVPLDALSRLEKLNNEQEPQVEIIPNPPLEPVSYPVSNPTIVTRTDLVQNKVREHHRGVLSSLRFDSETFDPSSKDGSVELHKSAKEAWQLGRKLWKELESGRLEKLVEKPEKNKPDSCPHSVSLTGSEFMNRENKLMELPCGLTLGSHITLVGRPRKAHPKEGDWSKLVSQFVIELQGLKTVEGEDPPRILHFNPRLKGDWSKKPVIEQNSCYRMQWGPAQRCEGWKSRDDEETVDSHVKCEKWIRDDDNYSEGSRARWWLNRLIGRRKRVKVEWPFPFVEEKLFVLTLSAGLEGYHINVDGKHVTSFPYRTGFTLEDATGLTVNGDIDVHSVFVASLPTSHPSFAPQRHLELSKRWQAPVVPDGPVEIFIGILSAGNHFSERMAVRKSWMQHVLITSAKVVARFFVALHGRKEVNVELKKEAEYFGDIVLVPYMDSYDLVVLKTVAICEHGALAFSAKYIMKCDDDTFVKLGAVINEVKKVPEGRSLYIGNMNYYHKPLRGGKWAVTYEEWPEEDYPPYANGPGYVLSSDIARFIVDKFERHKLRLFKMEDVSVGMWVEHFKNTTNPVDYRHSLRFCQFGCVENYYTAHYQSPRQMICLWDKLLRQNKPECCNMR
What is the function of this protein?
Possesses hydroxyproline O-galactosyltransferase activity.  Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs).  Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues.  Utilizes UDP-galactose solely as sugar donor.  The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition.  AGP glycans play essential roles in both vegetative and reproductive plant growth.
What are the official names of this protein?
Hydroxyproline O-galactosyltransferase GALT5, AtGALT5, Beta-1,3-galactosyltransferase 18.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: FMT_CHLPN
Sequence: MNLKVVYFGTPTFAATVLQDLLHHKIQITAVVTRVDKPQKRSAQLIPSPVKTIALTHGLPLLQPSKASDPQFIEELRAFNADVFIVVAYGAILRQIVLDIPRYGCYNLHAGLLPAYRGAAPIQRCIMEGATESGNTVIRMDAGMDTGDMANITRVPIGPDMTSGELADALASQGAEVLIKTLQQIESGQLQLVSQDAALATIAPKLSKEEGQVPWDKPAKEAYAHIRGVTPAPGAWTLFSFSEKAPKRLMIRKASLLAEAGRYGAPGTVVVTDRQELAIACSEGAICLHEVQVEGKGSTNSKSFLNGYPAKKLKIVFTLNN
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: MIAA_HELPY
Sequence: MIKEGFLIKTPKKLIALLGPSGSGKSALSIELAQELDAEIFSLDSLSIYKDINIASAKPSLKERKNIKHYALDHLNIDEKNNAPLFKTLLEDAMRVSSKEILLIVGGSSFYLKSILEGLSRMPKLSGEEVVKIEREIATLSNPYIFLKSIDPNMAFKIHPNDTYRTHKALEIFYATCTPPSEYFKANPKKPFEHAISLFALSIEKSALHNNIKRRTKNMLHSGLVEEIKALYTQYPKDSQPFKAIGVKESVLFLEKRLTLKELEEAITSNTMKLAKRQNTFNKTQFNNLYVGSAEEVRHAILKHSKSGIKG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: NS1_I68A5
Sequence: MDSNTVSSFQVDCFLWHVRKQVVDQELGDAPFLDRLRRDQKSLRGRGSTLDLDIEAATRVGKQIVERILKEESDEALKMTMASAPASRYLTDMTIEELSRDWFMLMPKQKVEGPLCIRIDQAIMDKNIMLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKTLQRFAWRSSNENGRPPLTPKQKRKMARTIRSKVRRDKMAD
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: NADA_VIBPA
Sequence: MSHILDKIDTVYPFPPKPIPLSEEEKSSYIASIKELLKQKDAVLIAHYYTDPEIQALAEETGGFVGDSLEMAKFGNRHPASTLIIAGVRFMGESAKILTPEKRILMPTLEAECSLDLGCPADKFSEFCDAHPDHTVVVYANTSAAVKARADWVVTSSIALEIVEHLDAEDKPIIWGPDRHLGSYIANKTGADMLLWQGECVVHDEFSADALRKMKSVYPDAAILVHPESPASVVELADAVGSTSQLIKAAKELPYQQMIVATDKGIFFKMQQLVPEKELIEAPTAGAGATCRSCAHCPWMAMNGLKAIEKALSEGGEEHEIFVDEALRVKSLIPLNRMLDFAEQLNMQVKGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL361_STRCO
Sequence: MKVKPSVKKICDKCRVIRRHGRVMVICDNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: PSBD_TETOB
Sequence: MTIAIGSTYQEKRTWFDDADDWLRQDRFVFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLATSYLEGCNFLTAAVSTPANSMAHSLLFLWGPEAQGDFTRWCQLGGLWTFVALHGSFGLIGFMLRQFEIARSVNLRPYNAIAFSAPIAVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQAEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLLVPVTGLWMSAIGVVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHERLVFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y297_CUPMC
Sequence: MRIILITGISGSGKSVALNVLEDAGYYCVDNLPAQFIPDLACYLADQGYSQLGVATDIRSRESLARLPDTVRELAANHQVQVLYLTASTDALVQRYSETRRRHPLSAQVDVGAAAGTPNDTSLIEAIEKERELLSPLAESAHRIDTSNVRTNTLRSWIKELIQDENENKNSQQLTLLFESFGFKHGVPSDADLVFDVRSLPNPYYDLALRPLTGRDAPVIDFLQSQPMVLAMAEDIRAYVEKWLPSFIADNRSYLTVTIGCTGGQHRSVFIAERLANYFRAHGNVLVRHRELAPAG
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Rmet_0297.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: MEX67_CANAL
Sequence: MSYRGRGGGYNNNRGQFSSGPHQHQQNVDSFVAANQYPIEIMGWNGASSGECINFISRKCKVIVSNYSVDSNSGVLKGYVKNESQANTLLNWSGVKFAGQSLRFSKGVSNISNQMGGGASTGSQSTIETISQFLKARYQPEIKMLNLSNVKQDPTLTAQGFFGSLSVSSKFFPALMKVASDLKLDVDSIDLSNNELQDLQTLTSMAQTFPKLQNLSLQNNNFTKIKVFETWRHKLNFLRELILFNNPIVQTNDPAEIQTIKLELMKSFPRLVVLSGEILRNEQVLIANLSFPFESPETMFFQDEDSRNLATNFIANYLKLWDANRSELMILYQNESQFSMQVDSSHPHLIESGNSGYSGSTDFGYYLNNSRNLTRVSSIKARMAKLSIGQEQIYKSFQQLPKTRHDIIATPELFSMEVYKFPTLNGIMITLHGSFDEVAQPEVDGSASSAPSGPRGGSRYHSGPKHKRIPLSKKSFDRTFVVIPGPNGSMIVASDTLLIRPYTSDFPWKVQKLPSNPTAATPGVSATSTPSPLPPTTITTPQLAPPGTGPTTADLPADIKARLNQIQQELLVKILLETKLNINYGIMLCEQSNWDYQQASVNFKNSAASLPSDAFVQ
What is the function of this protein?
Involved in the export of mRNA from the nucleus to the cytoplasm.
What are the official names of this protein?
mRNA export factor MEX67.
What is the protein family that this protein belongs to?
Belongs to the NXF family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm.
Protein: GSE1_HUMAN
Sequence: MKGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCLALPAMHWPRGYLKGYPR
What are the official names of this protein?
Genetic suppressor element 1.
Protein: MTLD_PHOPR
Sequence: MKAVHFGAGNIGRGFIGKLLSDANVAVTFADIDKPLVDQLSHDQSYKVKVVGSQCQVDTVTHVTAVNSASQDVIDRIVHTDLVTTAVGPNVLDIIAKTIATGLAQRFEANNEKSLNIIACENMVRGTTHLKNEVYKHLDEQYHARADALVGFVDSAVDRIVPPSEAANDPLEVTVESFSEWIVDKQQFKGDIPVIEGMEMTDNLMAFVERKLFTLNTGHIMTAYLGALKGHETVRDAIEDNEIREQVKAAMQESGEVLIKRYGFDREVHNAYIEKILGRFANPYLRDEIDRVGRQPIRKLGENDRLIKPLLGTIEYGTENKTLLKGIAAAFMYTNESDPQAVELQTSLKEQGLRPTLAHYTGIDADSKEAKTIETIFLQLS
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: CYNS_COPC7
Sequence: MTPAVSPAHTVLFEAKARKGISFEQIGKAIGRDEVWVASAFYGQAKFNEEELKKLSEVLEISSAQIVKELGDQWFPNRGLGPVPPSDPVIYRLFEGVLVYGHPIKAIIHEKFGDGIMSMIDCNINVERKPDPKGDRVVVTFDGKFLPYSKW
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: PIP28_ORYSJ
Sequence: MAAGSGSGSNPKDYQDPPPAPLVDTGELGKWSLYRAAIAEFTATLLLVCISVSTVIGEKRQSGEGGAGVLGIAWAFGGLIFVLVYCTAGISGGHMNPAVTFAMVLARRVSLPRAALYTMAQCVGAVCGAGLARAMHGGGQYARHGGGANELAAGYSAGAGVVAEMVGTFVLVYTVFSATDPKRKARDSHVPVLAPLPIGLAVLVVHLATIPITGTGINPARSLGPALVLGLGTTKAWSHLWIFWVGPFAGAAAAMIYHHYILRGAAAKAFASSSYRSPHF
What is the function of this protein?
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
What are the official names of this protein?
Probable aquaporin PIP2-8, OsPIP2;8, Plasma membrane intrinsic protein 2-8.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TSAD_BARQU
Sequence: MRLLGIETSCDETAAAVIEHNIEGNSQILSNIVWSQTDNHAPYGGVVPEIAARAHVEILDDLILKALTDAHTKLKDIDAIAVTSGPGLIGGLLVGVMSAKALSLATGKPFIAVNHLEGHALTAVLTHNVAFPYLLLLVSGGHTQTILVHEVGNYQRLGTTIDDALGEAFDKTAKLLGLPYPGGPALEKAALLGDKNRISLPRPLKGEKRLDFSFSGLKTAVRQAATAMSPLTENDVADIAASFQAAVTDTVYDRVHLALQYFTHQYPLSHYKGRRPPALVVAGGVAANQAIRLTLQELAHQHGFEFIAPPLSLCTDNAAMIAFAGAQKFARGEKNSFDIAPRSRWPLDEKAAPLIGTGRRGTKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2486_STAAM
Sequence: MMHSKKLMLGICLVLLIILIVGYVIMTKINSRSAQIKDTFNQTLKLYPTKNLEDFYDKEGFRDQEFEKGDKGNWIVDSEMVIELKDKKMESRSMVLYINRNTRTTKGNFIVRELWEDSKGYAQSKDTKYPVKMEHNRIIPTKPIADDKLRKEIENFKFFVQYGDFKDINDYKDGDISYNPNVPSYSAKYQLKNDDYNVKQLRKRYNIPTNKAPKLLLKGDGDLKGSSIGSKNLEFTFVENKEENIYFSDSINFKPTE
What are the official names of this protein?
Uncharacterized protein SAV2486.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ISPD_CHLCV
Sequence: MDPKCSLILLSGGKGERFGANQPKQYLPFQGEPLILHALKTALHIPEITEVIVVCDVSYRHIFEGFPVKFAESGKRRQDSVFSGLQHVSNPWVLIHDGVRPFIYPDEVTELIAVAQQTGAATLVSNVPYTIKQRHPVKTLDRDALSIVHTPQCVKTEILSAGLEFASREGITLVDDTQAAELLDIPVSLVSSKHPQIKITYPEDLTIAHALL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: VIRC_HYPVG
Sequence: MADQQQNPQESELLLTSAGYVSTFPAPGLRRTVRHITGHNAEGKGVFIQTDCGDHHRIIGNEQALANIIYSTKETPVEMNGDVDLKYAKENEPPLHIHNGSVCRMIDFAPNVISPMHRAVSLDYGIVIEGEFKLILDSGESRIMRQGDVSVQRASAHQWHNITGNGTLPGRMMWVLLDCKPIVINDIDFMECSQ
What is the function of this protein?
Cupin-domain-containing oxidoreductase; part of the gene cluster that mediates the biosynthesis of virensols and trichoxide, fungal natural products that contain or are derived from a salicylaldehyde core (PubMed:31790246).  The pathway begins with the synthesis of the reduced chain in virensol C by the highly reducing polyketide synthase virA via condensation of one acetate and 8 malonate units (PubMed:31790246).  VirA has interesting programming rules since the first 2 ketides are fully reduced, the 3 following ketides undergo beta-dehydration, and the last 3 ketides are only reduced to beta-hydroxys to yield the trihydroxy portion (PubMed:31790246).  The production of aldehyde virensol C by virA alone is surprising, since virA does not contain a reductase (R) domain that is typically associated with reductive product release in HRPKS (PubMed:31790246).  The cupin-domain enzyme virC is involved in enhancing virA product turnover (PubMed:31790246).  The short-chain dehydrogenase virB then oxidizes the C-7 alcohol of virensol C to a ketone, yielding virensol D (PubMed:31790246).  Virensol D is further transformed to salicylaldehyde 5-deoxyaurocitrin by the short-chain dehydrogenase virD (PubMed:31790246).  VirD catalyzes the dehydrogenation of C-3 to form the beta-ketone aldehyde, which is followed by the generation of the nucleophilic C-2 that is required for the intramolecular aldol condensation between C-2 and C-7, itself followed by dehydration and aromatization which leads to salicylaldehyde 5-deoxyaurocitrin (PubMed:31790246).  While the dehydrogenation of virensol D is definitely catalyzed by virD, the aldol condensation and dehydration may be uncatalyzed or assisted by virD (PubMed:31790246).  The short chain dehydrogenase virG then converts salicylaldehyde 5-deoxyaurocitrin into virensol B which is further hydroxylated by the cytochrome P450 monooxygenase virE to yield the hydroquinone virensol A (PubMed:31790246).  VirI then may oxidize virensol A to form the quinone, while virH performs the epoxidation (PubMed:31790246).  Finally, the two remaining short-chain dehydrogenases, virK and virL, are probably responsible for reducing the ketones to the corresponding alcohols to furnish the epoxycyclohexanol structure in trichoxide (PubMed:31790246).
What are the official names of this protein?
Cupin-domain-containing oxidoreductase virC, Trichoxide biosynthesis protein virC, Virensol biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the virC family.
Protein: THIG_BRUC2
Sequence: MLEFYGKRFESRLLLGTAQYPSPSILADAVRASLSRIVTVSLRRESGEARAGQDFWALIKALGVAVLPNTAGCHTPREAITTAHMAREVFGTNWIKLEVIGDTDTLQPDPFGLVEAARILCDESFEVFPYMNDDLIVAERLIEAGCKVLMPWGAPIGSGRGLNNPYALKTMRAHFPDIPLVVDAGIGVPSHAAAAMELGFDAVLINTAVAKAGDPAAMARAFALAVEAGRLAYEADPIEARDMASPSTPLLGKAFL
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.