PharMolix/UniProtQA huggingface dataset:
Protein: POGZ_HUMAN
Sequence: MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTTVSVSQQPVSAPVPIAAHASVAGHLSTSTTVSSSGAQNSDSTKKTLVTLIANNNAGNPLVQQGGQPLILTQNPAPGLGTMVTQPVLRPVQVMQNANHVTSSPVASQPIFITTQGFPVRNVRPVQNAMNQVGIVLNVQQGQTVRPITLVPAPGTQFVKPTVGVPQVFSQMTPVRPGSTMPVRPTTNTFTTVIPATLTIRSTVPQSQSQQTKSTPSTSTTPTATQPTSLGQLAVQSPGQSNQTTNPKLAPSFPSPPAVSIASFVTVKRPGVTGENSNEVAKLVNTLNTIPSLGQSPGPVVVSNNSSAHGSQRTSGPESSMKVTSSIPVFDLQDGGRKICPRCNAQFRVTEALRGHMCYCCPEMVEYQKKGKSLDSEPSVPSAAKPPSPEKTAPVASTPSSTPIPALSPPTKVPEPNENVGDAVQTKLIMLVDDFYYGRDGGKVAQLTNFPKVATSFRCPHCTKRLKNNIRFMNHMKHHVELDQQNGEVDGHTICQHCYRQFSTPFQLQCHLENVHSPYESTTKCKICEWAFESEPLFLQHMKDTHKPGEMPYVCQVCQYRSSLYSEVDVHFRMIHEDTRHLLCPYCLKVFKNGNAFQQHYMRHQKRNVYHCNKCRLQFLFAKDKIEHKLQHHKTFRKPKQLEGLKPGTKVTIRASRGQPRTVPVSSNDTPPSALQEAAPLTSSMDPLPVFLYPPVQRSIQKRAVRKMSVMGRQTCLECSFEIPDFPNHFPTYVHCSLCRYSTCCSRAYANHMINNHVPRKSPKYLALFKNSVSGIKLACTSCTFVTSVGDAMAKHLVFNPSHRSSSILPRGLTWIAHSRHGQTRDRVHDRNVKNMYPPPSFPTNKAATVKSAGATPAEPEELLTPLAPALPSPASTATPPPTPTHPQALALPPLATEGAECLNVDDQDEGSPVTQEPELASGGGGSGGVGKKEQLSVKKLRVVLFALCCNTEQAAEHFRNPQRRIRRWLRRFQASQGENLEGKYLSFEAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSLEGGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKDVAENAGLFIDFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVGTGEPWCDVVLAILADGTVLPTLVFYRGQMDQPANMPDSILLEAKESGYSDDEIMELWSTRVWQKHTACQRSKGMLVMDCHRTHLSEEVLAMLSASSTLPAVVPAGCSSKIQPLDVCIKRTVKNFLHKKWKEQAREMADTACDSDVLLQLVLVWLGEVLGVIGDCPELVQRSFLVASVLPGPDGNINSPTRNADMQEELIASLEEQLKLSGEHSESSTPRPRSSPEETIEPESLHQLFEGESETESFYGFEEADLDLMEI
What is the function of this protein?
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion.  Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864).  Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387).
What are the official names of this protein?
Pogo transposable element with ZNF domain, Suppressor of hairy wing homolog 5, Zinc finger protein 280E, Zinc finger protein 635.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).
Protein: LSPA_SHIBS
Sequence: MSQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAIGISVILAVMMYRLKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSRAKKQ
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUSD5_HUMAN
Sequence: MTAEGPSPPARWHRRLPGLWAAALLLLGLPRLSVRADGKFFVLESQNGSQGLQLEAARLSCKSRGAHLASADELRRVVQDCSFAVCTTGWLADGTLGTTVCSKGSGEQQIMRAVDVRIESNPVPGGTYSALCIKDEEKPCGDPPSFPHTILQGRTGLEMGDELLYVCAPGHIMGHRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEDNFPDDRSVSFRELMEDSRTEADEDRGQGDSSEEAPKQDRLVSISVGRENIARDKVFVPTTGLPGAGSSVPADSPGSRLLQKHLFWFPAEAFHKPGLEKEVDDDTKKQFSAGDNHSGVKLVPGEPETKVIYGNTDGPSGPFVGKNDSKAGDPVVSSSDESWLDGYPVTEGAWRKTEAEEEEDGDRGDGSVGLDENVLVTPDQPILVEVKKPKSSTLTPSEGMTHSSVLPSQMLDVEALALRPVNASETEGIGDGDLTKYQSTLPWRFITEESPMATLSYELTSSTLEILTVNTVKQTPNHIPSTIMATTQPPVETTVPEIQDSFPYLLSEDFFGQEGPGPGASEELHPTLESCVGDGCPGLSRGPVIATIVTVLCLLLLLAGVGMVWGYRKCQHKSSVYKLNVGQRQARHYHQQIEMEKV
What are the official names of this protein?
Sushi domain-containing protein 5.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: DPOL_BPSPB
Sequence: MIGCHCHTDRSNIRLLDSTNSVKELLKTAVKMEYKGLAITDHEVLSAHLDAIRTVREMKKKGDMPEDFKLILGNEAYLVDSLEEVRDNYKSGVTKFPHFLMLAMDPKGHEQLRILSSQAWENSFYTGTMERVPTVKKDVEELLSKDPGHIIATTACLGSEVNIHLLKIKAFEETGDSQSIKQHKLKIHEFITWCIEVFGKDKFFIELQPALSEEQIYCNKKLIDIANGYDLQMIVTTDAHYLRPEDRAIHQAFLNAKDGEREVDSFYEACFVQNVDEIHERMDYIDKEVIDQAIKNTMLIGEMIEDYTIEHEPIIPKMELPNFKLRHLFKPAYDQYEYIKKMSESADEQDRYLLKLIEDGFEEKLKTSELTREAFHKILNRINVELGELWEISQKLNQSMSSYYITVREIINIIWDDECGGDSLVGAARGSAAGYLVNYLLDNTQINPMQYDLPHWRHIHKSRPDLPDIDIDTEGSKRQKILKALRERFGDKRVLQIATFGTEGSKSALQTACRGLGIDNDISQYLSGMIPFERGSNWPLKHCFYGDKETGRKPIKEFIREVEQYPNLKETALKIEGLTNKRSSHAAGVIIFNDEYTKSNAMMKTPKGAYITQFNMGDSEAMGSVKFDLLTIEALDKIRVTLDQLIENNEIEWQGSLKETYNKYIHPDVIEYEDDKLWEMAGNGEIMDLFQFSTEVGHQSVVKVKPKNLLEAAVTNSLMRLMSDGEEQPVDTYVKYKNNLNKWYEEMTRYGLSEKEIRVMERHLKDIYGVADTQEVVMQMVMDKDIANFDIKESNYLRKSIAKKKEDVLKEVEELFFKKGKEIGTSDNLLNYVWNVQFKRQFGYSFSLLHTLAYSIIALQELNLNYRYNPLYWNTACLTVNSGGIDTEDTKDNKKTAATNYGKVASAIGNIRQRGIKIDLPDINKADFGFRTDINNNSILFGLKGMNGIGDDVIHHIVLNRPYSDFNDFIERMFKSGIIKKGQVIQLIKGGCFDSFGNRQEIMKAFISLISEPKSKLTLSNLKMLIENNIVPSEFAQEVRFFRFKDYISKKVYKTLKSPKDKLFLLDDVSASFYNQHFSEDSVVDMLNGQLVISEKAFKKEYDNKMSNIKSWITTEEPLKKLNDCLLIKEWEKYADGSLGKWEMDSLSYYYNDHELSGVNFAKYDIADFYKLPAEPVKGKPYQWRGKTLYEYETTRIIGTVLDRDKNKHAITLLTPTGVVTVKQWSGSFSHYNKQISRSIGGGKKEVIEKSWYTRGTLLMFTGFRRGNNFIPKVYKDSIYNHTVCRIDFVDNEGSMSLTTKRAEI
What is the function of this protein?
Replicates viral genomic DNA.
What are the official names of this protein?
DNA-directed DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family.
Protein: RECF_MYCSJ
Sequence: MFVRHLTLTDFRSWARADLELEPGRTVFVGPNGFGKTNLVEALWYSATLGSHRVASDAPLIRAGAPRAVVSTIVVNEGRELAVDLEITTGRANKARLNRSPVRSPREVLGVLRAVLFAPEDLALVRGDPGERRRYLDELATTRRPSIAGVRADYDRVIRQRTALLKSAAGARYRGDRSVLETLDVWDGHLAAHGALLMAARADLVHHLAPEVEKAYQLLAPGSRPAAIRYRTSIDAEDDVSAEYYEAALLDAMTRRRDAELERGVCLVGPHRDDLELRLGDQMAKGYASHGESWSMALSLRLAAYELLRTDGSDPVLLLDDVFAELDAARRRALAEVAASAEQVLVTAAVAEDIPADWDARRIVIRMQDDDDGRVSMVES
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P3F2B_XENLA
Sequence: MATTASNHYNLLGSGSSIVHADPGGMQQAQSYRDAQTLVQSDYTLQSNGHPLSHAHQWITALSHGDGAPWATSPLGQQDIKPTVQSSRDELHGSGTLQHQSRAPHLVHPAHGNHHGPGAWRSTGSTHLSSMASSNGQGLLYSQPSFTVNGMINPGSGQGMHHHGLRDSHDDHHGDHGHQQPSQTQQQQQQHSQLQGGHHDHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPAAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTIPGAEDVYGASRDTPPHLGVQTSVQ
What is the function of this protein?
Transcription factor that may be implicated in patterning of the central nervous system during early development.
What are the official names of this protein?
POU domain, class 3, transcription factor 2-B, Transcription factor POU3-B, XlPOU3B.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: VPK21_HUMAN
Sequence: WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPTPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQKREGIGYPF
What is the function of this protein?
Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle.  Endogenous Pro proteins may have kept, lost or modified their original function during evolution.
What are the official names of this protein?
Endogenous retrovirus group K member 21 Pro protein, HERV-K_12q14.1 provirus ancestral Pro protein, Protease, Proteinase, PR.
What is the protein family that this protein belongs to?
Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.
Protein: TMEDE_DROVI
Sequence: MRNQFICLALVLCTLHSACGLYFHISETERKCFIEEVPDETTVIVNYKVELYDPRSNGFMPSSPGIGMHVEVRDSDDKVILSRVYSSQGRMSFTSHTPGEHVICMYSNSTAWFNGAQLRVHLDIQVGEHAIDYANVAQKEKLTELQLRIRQLLDQVEQITKEQNYQRYREERFRHTSESTNSRVLWWSLAQTVVLVCMGFWQMRHLKSFFEAKKLV
What is the function of this protein?
Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo.  Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.  Involved in Golgi organization (By similarity).
What are the official names of this protein?
Transmembrane emp24 domain-containing protein eca.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: HIS6_ACET2
Sequence: MVTKRIIPCLDVHNGRVVKGVNFVNIRDAGDPVEIASYYDKAGADELTFLDITASAEARNIMIDVVRRVAEQVFIPFTVGGGIRTVEDFREILKAGADKVSINSAAVKRPELISEAASRFGSQCVVVAIDAKRRDDNSGWDVYINGGRINTGKDAVEWAVEVEKLGAGEILLTSMDCDGTKKGYDIELTRKVSESVRIPVIASGGAGTMEHFREALVEGKADAVLAASLFHYREIEIMELKKYLKENGIEIRM
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AHPD_MYCTO
Sequence: MSIEKLKAALPEYAKDIKLNLSSITRSSVLDQEQLWGTLLASAAATRNPQVLADIGAEATDHLSAAARHAALGAAAIMGMNNVFYRGRGFLEGRYDDLRPGLRMNIIANPGIPKANFELWSFAVSAINGCSHCLVAHEHTLRTVGVDREAIFEALKAAAIVSGVAQALATIEALSPS
What is the function of this protein?
Together with AhpC, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system.
What are the official names of this protein?
Alkyl hydroperoxide reductase AhpD, Alkylhydroperoxidase AhpD.
What is the protein family that this protein belongs to?
Belongs to the AhpD family.
Protein: NUOA_ECOLC
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARSKNVPFESGIDSVGSARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLVRIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURG_METPP
Sequence: MTQRHLVVMAAGTGGHIIPGLAVAQEMQHRGWTVSWLGTEQGMENRLVPPAAESGIEMDTIAFSGLRGKGLLHTLTGGLRLLGAFAACAKILRRRATTAVLGMGGYVCFPGGLMASLLGKPLILVNADAALLMSNRALKPVADRIAFGFDGAAAATTRQAVVTGNPVRAEIETLPEPPVRYAGREGPLRVLVVGGSLGARVLNETLPQALALLAPAERPRVLHQTGQLNRDGVKEAYAAVGIDDGVEVLAFIDDMAARLAHCDVVICRAGAVTVSELCAAGVASVLVPLIVSTTSHQRDNALYMAQHGAAIHLPQSELTPQALAERLRTLDRPQLLGMAEKARALSRPRAAARVADEIERLVRKDGL
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DAPA_PERMH
Sequence: MFKGSIVALITPFKDGAIDRKSLKRLIDFHVEKGTDGIVIAGTTGESATLTFSEHEDLIKMAVEFADKRIPIIAGTGANATHEAIALTKSAEKAGADGSLQIVPYYNKPTQEGIYQHFKAIAEETSIPLILYNIPSRTGVDMLPETFARLYSDFPNVIGIKEATGNVARVSEMISLTNPDVVILSGDDALTLPMMAVGAKGVISVANNLVPEDIATMCRLALEGRFEEARQIHDRYWKLFKTLFIETNPIPVKTAAYLMGLIDDIEMRLPLYYMKPENEEKLKSVLKDYGLIR
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_AZOVD
Sequence: MQWETVIGLEIHAQLATRSKIFSGSATAFGAEPNTQASLIDLGMPGTLPVLNEETVRMAVRFGLAIEAEIGHTNVFARKNYFYPDLPKGYQTSQMDKPIVGKGHLDITLEDGTLKRIGITRAHLEEDAGKSLHEDFHGMTGIDLNRAGTPLLEIVSEPDIRSAKEAVAYVKAIHALVRYLGICDGNMAEGSLRCDCNVSVRPRGQEAFGTRAEIKNVNSFRFIEKAINHEIQRQIELIEDGGKVIQETRLYDPNKDETRSMRGKEEANDYRYFPCPDLLPVVLEDGFVERLRETLPELPNQKRERFQSQYGLSAYDASVLSASREMAEYFEAVFEVCGDAKLAANWVMGELSSLLNKEGLEIERSPVSAEQLGGLIRRIQDNTISGKIAKMVFEALAADEGASADAIIERKGLKQVTDTGAIESMLDEMLAANAAQVEQYRAADEAKRAKMFGFFVGQAMKASKGKANPGQVNELLKKKLEG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: LAC1_TRAHI
Sequence: MSRFQSLLAFVVASLAAVAHAAIGPTADLTISNAEVSPDGFARQAVVVNNVTPGPLVAGNKGDRFQLNVIDNLTNHTMLKSTSIHWHGFFQKGTNWADGPAFVNQCPISSGHSFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPHASLYDVDNDDTVITLADWYHTAAKLGPAFPLGADATLINGLGRSPSTTAADLAVINVTKGKRYRFRLVSLSCDPNHTFSIDGHDLTIIEVDSINSQPLVVDSIQIFAAQRYSFVLNADQDVGNYWIRANPNFGNVGFAGGINSAILRYDGADPVEPTTTQTTPTKPLNEVDLHPLATMAVPGSPVAGGVDTAINMAFNFNGTNFFINGASFVPPTVPVLLQIISGAQNAQDLLPSGSVYSLPSNADIEISFPATAAAPGAPHPFHLHGHAFAVVRSAGSTVYNYDNPIFRDVVSTGTPAAGDNVTIRFRTDNPGPWFLHCHIDFHLEAGFAVVFAEDIPDVASANPVPQAWSDLCPIYDALDVNDQ
What is the function of this protein?
Lignin degradation and detoxification of lignin-derived products (By similarity).  Has activity towards guaiacol (PubMed:2394718).
What are the official names of this protein?
Laccase, Benzenediol:oxygen oxidoreductase, Diphenol oxidase, Ligninolytic phenoloxidase, Urishiol oxidase.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL6_PHOLL
Sequence: MSRVAKAPVVIPTDVEVKLDGQVISIKGKNGELSRTIHSAVEVKHADNQLTFAPRDGYVDGWAQAGTTRSLMNAMVIGVTEGFTKKLQLVGVGYRAAVKGNVINMSLGFSHPVDHELPAGITAECPSQTEIVLKGADKQVIGQVAAELRAYRRPEPYKGKGVRYADEVVRIKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ASSY_STAA2
Sequence: MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMGAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTMCB_MYCPN
Sequence: MRKKLAKVKVHIQSLDSLLSSMTMPIIGIFIAWGLLASFFIPSGWTPDKNLALMVGIGIQYVIPTIIXFFGGKKIYEIRGGVIAVIIAIAVIAAGQTEAFTKIVGQKSVMFLGVMIFGPIAALILKHTEKFWIHRIKSGFEMLVNNFYLGFLGFALIFPSFYLSIYLIGYIQLGLKLLVEIMQQYKLYPIAAIVIEPAKVLFLNNAINHGVLTPLGLQQVRDSGKSILFLLESNPGPGLGLLVAFLIFFFKRDKKLSSNAASSSPIHLFGGIHEVYFPFVLLKPVLILATIAVGVVGNGILQIFNAGTIAPVSPGSVIAGFLQINKTPLDVAGYALALVLSAVTSLLISLLLLSLTRKKQLKTLQEAQAQVAEMKQTPAKKPRQKDTPAIATKIDFSQVTFVCDAGMGSSTMGAAIFRKELKNQNIEDITVINKAIVDLKDEKVIITISQLYDRVKAKRADATIYTINQFLDKQGYLTIIEKIKNEKN
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II CmtAB PTS system is involved in D-mannitol transport.
What are the official names of this protein?
PTS system mannitol-specific EIICB component, EIICB-Mtl, EII-Mtl.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UXAB_ECOK1
Sequence: MKTLNRRDFPGAQYPERIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGALDKGWIIIPCELIDYNGDALRELVLRYAQEWALPEAFIQWLDQANSFCSTLVDRIVTGYPRDEVAKLEEELGYHDGFLDTAEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAMNDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKANGTLPARLTFALAALIAFYRGERNGETYPVQDDAHWLERYQQLWSQYRDRVIGTQELVAIVLAEKDHWEQDLTQVPGLVEQVANDLDAILEKGMREAVRPLC
What are the official names of this protein?
Altronate oxidoreductase, Tagaturonate dehydrogenase, Tagaturonate reductase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family. UxaB subfamily.
Protein: LPXD_BURP0
Sequence: MALTLEALAARFGGEIVGDGRCEVGALAPLDQAGPRQLAFLANPKYLAQVETTGAGAVLIAPGDLEKLGAAAHGRNFIVTPNPYAYFARVAQMFIDLAAPPRAAGVHPSATIDPAAQVAASAVIGPHVTVEAGAVIGERAQLDANVFVGRGTRIGDDSHLYPNVAIYHGCTLGPRAIVHSGAVIGSDGFGFAPDFVGEGDARTGAWVKIPQVGGVKVGPDVEIGANTTIDRGAMADTVIDECVKIDNLVQIGHNCRIGAYTVIAGCAGIAGSTTIGKHCMIGGAVGIAGHVTLGDYVIVTAKSGVSKSLPKAGIYTSAFPAVEHGDWNRSAALVRNLDKLRDRIKALETALVAREGDAGGA
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: IF1_AERS4
Sequence: MAKEDSIEMQGTILETLPNTMFRVELENGHVVIAHISGKMRKNYIRILTGDKVTVALTPYDLSKGRIVFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_STRPS
Sequence: MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGDDMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSRLVDILSENLDEGFQYFPSDQITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMKRDEETDKVHIRATIMVERDSQKGIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWVKVKKNWRDKKLDLADFGYNEREY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: HLH26_CAEEL
Sequence: MSSSPTSSSSGSPSSHGHRSETEKQRRDDTNDLLNEFKKIVQKSESEKLSKEEVLFRIVKLLSGIQLHHESFSTSPGPIRSIKKIKSDREQVRRNKRVAAYRELRKFIALNNLSSSEEIDKMENLKVLEIIFEVIRGKSITCTVPCLPFPILPFLPVFPVYSPLVFNSYNQFSLYPPHMPTVQIPIVPSSSFEIDALEIEENEKDIDIVG
What is the function of this protein?
As a homodimer binds DNA via the E-box sequence 5'-CACGTG-3' (PubMed:19632181).  Represses lag-2 transcription during embryogenesis via Notch signaling, in an unc-37-dependent manner (PubMed:15935776).  Also represses tbx-37 independent of Notch signaling (PubMed:15935776).  In the intestine, plays a role in probiotic-mediated protection against infections by pathogens such as S. enterica (PubMed:35263319).  This is most likely by positively regulating the expression of genes such as bar-1 upon exposure to probiotic bacteria such as the E. faecium (PubMed:35263319).
What are the official names of this protein?
Helix-loop-helix protein 26.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACKA_STRPQ
Sequence: MSKTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDHTEAVKILLNDLIHFGIIAAYDEITGVGHRVVAGGELFKESVVVNDKVLEQIEELSVLAPLHNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLYPIPQKYYTDYKVRKYGAHGTSHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGKSVDTSMGFTPLAGPMMGTRSGDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDIEAGLQEDNPDAVLAYNIFIDRIKKCIGQYFAVLNGADALVFTAGMGENAPLMRQDVIGGLTWFGMDIDPEKNVFGYRGDISTPESKVKVLVISTDEELCIARDVERLKNTK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHPRS_HELPY
Sequence: MIVKRLNPDALKNALQKIGPEKIAQDRMHQKGVSFVFEIQHLPLSATLILKQEAISVGGDFATPRDCILAKEPFYDGVLIASAKQLERLIVKCHSQPFGLKHLAQELKSHLKAPKPNTPQIMAVLNLTPDSFYEKSRFDSKKALEEIYQWLEKGITLIDIGAASSRPESEIIDPKIEQDRLKEILLEIKSQKLYQCAKFSIDTYHATTAQMALEHYFSILNDVSGFNSAEMLEVAKDYKPTCILMHTQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYVLQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQDRLAGTLSLHLMALQNGASVLRVHDIDEHIDLIKVFKSLEETD
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of dihydropteroate, the immediate precursor of folic acid and the reduction of dihydropteroate to tetrahydropteroate.
What are the official names of this protein?
Bifunctional dihydropteroate synthase/dihydropteroate reductase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DHPS family.