PharMolix/UniProtQA huggingface dataset:
Protein: LFTR_ECOL5
Sequence: MRLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQRGIFPWFSPGDPILWWSPDPRAVLWPESLHISRSMKRFHKRSPYRVTMNYAFGQVIEGCASDREEGTWITRGVVEAYHRLHELGHAHSIEVWREDELVGGMYGVAQGTLFCGESMFSRMENASKTALLVFCDEFIRHGGKLIDCQVLNDHTASLGACEIPRRDYLNYLNQMRLGRLPNNFWVPRCLFSPQE
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_HISS2
Sequence: MTIFAKDKLIAYGQLMRLDKPIGTLLLLWPTLWALYLAEKAMPTLSVLAIFIFGVFLMRSAGCVINDYADRHIDGKVKRTSLRPLSTGRATPREAKWLFIVLVFCSFLLVLCLNLYTIGLSVIAVILAFIYPFMKRYTHLPQFFLGAAFGWSIPMAYGATIEALPLECWLLFIANLSWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIIALLQIITLIFLFSVGYLSQLNNRYFIVLAIAGLFFVYQCRLTKNRDRESCFNAFLNNNYFGLTVFIAVLFGI
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RBFA_DELAS
Sequence: MATRKSAAPNRSFKVSDQIQRDLAELIARELKDPRVGMVTLQSVEVTPDYAHAKVYFSLLVGDPQATQEALNQAAGFLRNGLFKRLHIHTVPTLHFIYDRTSERAADMNALIAKAVSSRGKEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_FRATT
Sequence: MIETDRIISANTAQTNDENVIDRAIRPKTLAEYEGQPAVREQMEIFIQAAKARKDALDHTLIFGPPGLGKTTLSNIIANEMGVELKQTSGPVLEKAGDLAALLTNLEENDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLVGATTRAGLLTSPLRDRFGIIQRLEFYSIDDLSKIVYRSAKLLNLDITTDGAMEIAKRSRGTPRIANRLLRRVRDYAQVKGSGVICFEIADKALSMLKVDPVGFDHMDHRYLLTLMEKFAGGPVGLDTMSAALSEEKGTIEDVIEPYLIQQGYIMRTARGRIATLLAYNHFKLKIPDNLSADQQQTLSI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CYC5_CLITE
Sequence: GIPCGESCVFIPCISTVIGCSCKNKVCYRNHVIAAEAKTMDDHHLLCQSHEDCITKGTGNFCAPFPDQDIKYGWCFRAESEGFMLKDHLKMSITN
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cliotide T5.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: CRR19_ARATH
Sequence: MYSSSSVSKRFVLVPIVVVVTTQLLLVRNVSSLNLTNSYLHHKCVVNQGKYKPGSKYEKSLDDIIQSFSNKDKDSYGFRTGYSMKAYGKEPDMVSITYQCRIDSRGPKCQSCVVTAGYELLRKRCPRYKEAIIWYDQCLVEFSSLDTSGQINYDDNFCMPSAKNLIGNSISLEERLHLLNNLTKIAVTKIDKNIEGIKKPVLYAAGEKRLGTKSLYGMVQCSADLSVQGCNECMLYYIVHFQECWESKQGVRVLSRSCNFRYELYPFISPKGSYYTKF
What are the official names of this protein?
Putative cysteine-rich repeat secretory protein 19.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: VKTG6_CYRSC
Sequence: MGTARFLSAVLLLSVLLMVTFPALLSAEYHDGRVDICSLPYDSGDCLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Serine protease inhibitor that inhibits chymotrypsin and blocks voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hs1b, U15-TRTX-Hs1b, Kunitz-type serine protease inhibitor huwentoxin-11g6, HW11g6.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 03 (sub-Kunitz) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FAT1_YEAST
Sequence: MSPIQVVVFALSRIFLLLFRLIKLIITPIQKSLGYLFGNYFDELDRKYRYKEDWYIIPYFLKSVFCYIIDVRRHRFQNWYLFIKQVQQNGDHLAISYTRPMAEKGEFQLETFTYIETYNIVLRLSHILHFDYNVQAGDYVAIDCTNKPLFVFLWLSLWNIGAIPAFLNYNTKGTPLVHSLKISNITQVFIDPDASNPIRESEEEIKNALPDVKLNYLEEQDLMHELLNSQSPEFLQQDNVRTPLGLTDFKPSMLIYTSGTTGLPKSAIMSWRKSSVGCQVFGHVLHMTNESTVFTAMPLFHSTAALLGACAILSHGGCLALSHKFSASTFWKQVYLTGATHIQYVGEVCRYLLHTPISKYEKMHKVKVAYGNGLRPDIWQDFRKRFNIEVIGEFYAATEAPFATTTFQKGDFGIGACRNYGTIIQWFLSFQQTLVRMDPNDDSVIYRNSKGFCEVAPVGEPGEMLMRIFFPKKPETSFQGYLGNAKETKSKVVRDVFRRGDAWYRCGDLLKADEYGLWYFLDRMGDTFRWKSENVSTTEVEDQLTASNKEQYAQVLVVGIKVPKYEGRAGFAVIKLTDNSLDITAKTKLLNDSLSRLNLPSYAMPLFVKFVDEIKMTDNHKILKKVYREQKLPKGLDGNDTIFWLKNYKRYEVLTAADWEAIDAQTIKL
What is the function of this protein?
Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:9079682, PubMed:11330068, PubMed:9988704, PubMed:12052836, PubMed:12601005).  The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities (PubMed:12052836).  Esterifies VLCFAs in the peroxisome matrix.  The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane (PubMed:22493507).
What are the official names of this protein?
Very long-chain fatty acid transport protein, Very-long-chain acyl-CoA synthetase, VLCS.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Lipid droplet. Cell membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Peroxisome.
Protein: SEY1_LEIIN
Sequence: MSLHLVDSDGHLQSEKRLKEYLTTIVAPSVSQSGSAATADDGDGDSALEAIGVNYHVVGVFGGQSSGKSTLLNHLFGTDFQTLNEAVRRGQTTKGAFIARANDALAGFEASGASVVADQLASGAADHSSCLNRAAAAAAAATKDAAYGEHGAPHTVPPLLVLDFEGTDGLERGEDQCFERQLSLFGLSIADTLIINMWAVDVGRFNAANLSLLRTIFEVNLQLFSHDNYEAEEKPTLLIVLRDFTEDDPAPSLATVRKSFDTIWEGITRPAQFAGASIDALFHLKYYVMPHYKLQKTEFMPSVETLRRWFGDSQCPDYLFSHRAMFRGVPLEGLPAYLTNCWEAIRTSKDLDIPTQREMLAQHRCKEAKVQELKTFRHFARHYEDRLLHGEMLLRLSEVLDEEMETRLASFYRQTKLYNSDVVGQYANELETELVDATLRVLNRLSKAIAAEVLSNTEPRVLNSVEESLRQLLKSAQTLPFSAGEGPSAAEAEEANDVERDAAHLVGAQRMDSPACQKLVRSFWRSLSSYVNEVVAEVAAMPPRAHLYGRYVALIAQDPTTRLNVLNIVTDALFQKVKSRVVSMADSACDTMHAGFERSLTHNSDGTARFFATTKGLQKAVPAAMQAGVVVLGSLFYFRLKLVAAGADDDGIGADVAGTALPQSRSARRVRHDQHRIVFSDNDAEAAFYLSYSTLDTAPKYPYDVPVTSADCEGEEAGAVADCILLSQQAIVRAYELYRQKCDFTTQLQLRTVEAAKQRLPAWVIPALFILGWNELLYVLTSPALLVLVVVICAVFFKQFFVSQWHAFEETGPASVVIPTKTVIHTLSTLVRSLLDYRPGPRTERTERSHDAAAAAEKEMPHVAATATHVDPTLGNANVPTAPSTMRHRTSRKLD
What is the function of this protein?
Probable GTP-binding protein that may be involved in cell development.
What are the official names of this protein?
Protein SEY1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ATP6_PROM1
Sequence: MGFLPFVFPFAELEVGQQLYWQIGNFRIHGQVFMTSWLLIGALLALVVIGTKKMERDPRGVQNLLEFLWDYIRDLARTQIGEKVYRDWMPFIGTLFLFIFVSNWGGALVPWKLIKLPSGELGAPTADINTTVALALLVSLSYFYAGLSNKGLRYFEYYVHPTPIMLPFKIVEDFTKPLSLSFRLFGNILADELVVAVLVFLVPLVLPVPVMFLGLFTSAIQALIFATLAAYYIGEAVEEHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PYRDB_GEOSM
Sequence: MQRPDMSVAVAGIKMRNPVMTASGTFGYGAEFADYLDLESIGAMISKGLSLKPKAGNPTPRIVETPGGMLNAIGLQNVGIDAFIEQKLPYLKNVNTPVIVNLYGNTLEEYGEVAARLDGLAGVAGIEVNISCPNVKQGGIVFGTDPGAAQEVVRLVKKNTSKPMIVKLSPNVTDVVVMAKACADAGADALSLINTLTGMAIDLERRRPVLANVTGGLSGPAIKPVALRMVWQVGKAVKLPLIGIGGIMNGRDALEFMLAGATAVQVGTASFLDPSAAQRIAREMEQYLADHNIESVSSLIGALEL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN672_MOUSE
Sequence: MFTAPGMATTQERPYSCSVCGKSFQYSAVLLRHERAHGGDKRFCCLECGERCARAADLRAHRWTHAGQTLYICSECGQSFSHSGLLDLHLGTHRRRSRTRPCRLCGRRFPHVPALLLHRARQHPPEKPHRCPLCARSFRQSALPFHLARAHPPEIITVTAPSPSTLYHCTQCPRAFHSSAGLRNHSRIHVVPSLSDPGTEAHLCGICGKSFSKSSTLTRHLQRHSGEKPFKCPECGKGFLESATLVRHQRTHTGEKPYACSDCGRCFSESSTLLRHQRSHQGERPHVCATCGKGFGQRYDLVVHQRSHTGERPFPCPQCGRGFTDRSDLTKHLRTHTGEKPYHCELCGKRFTCISNLNVHLRNHAGHKPHKCPECGKSFSVASKLALHRKTHLGERTAECTECGKFFSHGRSLSQHQRSHRRARAAAMAATTTTTVVTEVTIGPSLTLTGPTEQEKSGLLVSPFQETC
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 672.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UDB14_RABIT
Sequence: MSVKHVSVLLLLLQLSCCFRTGSCGKVLVWPMDFSLWMNLNVILDELVRRGHEVIVLRNSASIFIDPSKQANIKFETFPIAATKDDLEDLFVHYVSTWTNARQNSQWKYFSLLQKLFSEYSDSCENACKEVVFNKTLMTKLQESRFDILLSDAIGPCGELLAELLKIPFVYSLRFTPGYTMEKYSGGLSVPPSYVPIILSDLSGKMTFMERVNNMLCMLYFDFWFQMFNKKRWDQFYSEVLGRPVTFSELVGKADMWLIRSYWDLEFPRPTLPNIQFVGGLHCKPAKPLPKEMEEFVQSSGEEGVVVFSLGSMVSNMTEERANLIASAFAQLPQKVIWRFDGQKPETLGPNTRIYDWIPQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMVGLPLFGEQPDNIAHMTAKGAAIRLNWKTMSSEDLLNALKTVINDPSYKENVMTLSSIHHDQPMKPLDRAVFWIEYVMRHKGAKHLRVAAHDLTWFQYHSLDVVGFLVSCAAFLIFLVIKSYLFVYQKLVKIGKKQKRD
What is the function of this protein?
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
What are the official names of this protein?
UDP-glucuronosyltransferase 2B14, UDPGT 2B14, EGT12.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: NPF_ARTTR
Sequence: KVVHLRPRSSFSSEDEYQIYLRNVSKYIQLYGRPRF
What is the function of this protein?
May perform an important neurotransmitter function and may regulate muscular activity.
What are the official names of this protein?
Neuropeptide F, NPF.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: GATA_CERS5
Sequence: MNANELTIAEARDALAKGELSAVDLTMACLTAIDAGTPLNAFVHLTPEIALDQARASDARRGEGAGALNGIPLGIKDLFCTRGVASQAASNILKGFKPEYESTVTSKLFAAGAVMLGKLNMDEFAMGSSNETSCYGDAVNPWKVDDRKLTPGGSSGGSAAAVAADLCLGATGTDTGGSIRQPAAFTGIVGIKPTYGRVSRWGIVAFASSLDQAGPMTKTVRDAAILLGAMAGHDPKDSTSADIPVPDFEAALTGDIRGKKIGIPREYRMEGMPAEIEALWAKGREMLADAGAEIVDISLPHTKYALPAYYVIAPAEASSNLARYDGVRYGHRAKLGQGDGIVDMYEKTRAEGFGKEVQRRVMIGTYVLSAGFYDAYYNRARKVRALIKRDFDQVFAEGIDAILTPATPSSAFGLGEMAHADPVEMYLNDVFTVTVNLAGLPGISVPVGLDAKGLPLGLQLIGRPWDEAGLLNHAHVLEQAAGFVEKPRKWW
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: GATC_BRUME
Sequence: MSVDISTVKRVAHLARIAVSEDDAERMTGELNAILGFVEQLNEVDVEGIEPMTSVTPMKMRMREDKVTDGGIAAAVVANAPVTEDNFFVVPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: YCIB_METPP
Sequence: MKFLFDLLPIVLFFVAFKVAEGQPDAAAAFASQHFGFLVSGGMVGPKEAPVLLATLVVIVATFAQIGWLLLRGRKVDTMLWVSLGLVTVLGGATVWFHNETFIKWKPSVLYWVMGTAFWLSHAVFRKNLLQTLMGGQLQLPPAVWRNLNFMWIAFFAFMGLANLYVAYSFPTDVWVNFKLFGGVGLMLLFTLAQGLYLSRHIKTEDE
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCNT3_XENLA
Sequence: MSLMAHVRRKLCRGHLLRCTLPLTLLLFLTVGLKHLAIDCNLAHNNDIPMGSCMASYYTALNLSAPGEKNCHRIIQGDTEEARRALLDNLMVKKRRLVATDGDYINATSDCKFFRERRKYITFSLSQVEQDFPIAYSMVIHDNIEMFERLLRAVYTPHNIYCVHVDKKSPESFQQAARAITSCFDNVFVASKLESVVYASWRRVQADLNCMEDLLQSNVQWRYLINTCGTDFPIKTNAEMVKALKSLNGHNSMESEIPPNYKKRRWEYHFELKEDSNKIVQTNTRKKPSPLPVPVFSGNAYIVVTRNFVNSLFVNPTAKKFIMWAKDTYSPDEYMWATLHRFAEMPGHMPAHQKYDTSDINAIARLVKWQSLEGDMNKGAPYIPCTGTHRRQVCVYGTGDLNWMVQQHHFFANKFDPKVDDNAIQCLEEYLRYKTFHPTENVA
What is the function of this protein?
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides.  Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis.  Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans.
What are the official names of this protein?
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, C2GnT-mucin type, C2GnT-M.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 14 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: KLK4_HUMAN
Sequence: MATAGNPWGWFLGYLILGVAGSLVSGSCSQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS
What is the function of this protein?
Has a major role in enamel formation (PubMed:15235027).  Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).
What are the official names of this protein?
Kallikrein-4, Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Prostase, Serine protease 17.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYP_PSEA8
Sequence: MRTSQYLLSTLKETPADAVVISHQLLLRAGMIRRLASGLYTWLPMGLRVLRKVETIVREEMNAAGALEVLMPAVQPAELWQESGRWEQYGPELLRLKDRHEREFCVGPTHEEVITDLARNELNSYKQLPINFYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHLSQDSLQQTYDGMYQAYSKIFSRLGLDFRPVQADNGSIGGSGSHEFHVLANSGEDDIVFSDSSDYAANIEKAEAVPRESARGSATEDMRLVDTPNTKTIAALVDGFQLPIEKTIKTLVVHGAEEGTLVALIVRGDHELNEIKAANQPLVASPLVFASEAEIRAAIGAGPGSLGPVNLPIACIVDRSVALMSDFAAGANIEDKHYFGVNWERDLPLPEVADLRNVVEGDPSPDGKGTLVIKRGIEVGHIFQLGTKYSEAMKLSVLSEQGKPVNLIMGCYGIGVSRVVAAAIEQNHDERGILWPSALAPFQIALVPLKYETESVKQATDKLYAELTAAGFEVLLDDRDKKTSPGVKFADMELIGIPHRIVISDRGLSEGVLEYKGRRDSESQNLPIGELMSFITEKLSR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1286_STAAW
Sequence: MNELEFVTKHRRHLHQHPELSLHEFETTAYIKAFLDSLNIKYDCPLETGVIAYLEGNGSHTIAYRADIDALPILEENDVPYRSQSDHVMHACGHDGHTTALMLFVQRCKDMQDAGQLPQNVVFIFQPAEETGGGANRLIKAGAFDKYPIEAVFGIHVNPFADEGIAVIRDEEITASATEYRFFLTGLSSHVADKEQGHSCGEALQHVLTQISQIQQFHLNGLKRNIVHIGHFKAGEAINTVPSNGYLEGTIRTYDIDDLTIVKNQMHKIAESVKLLFNVDCEVKFAEGYPPTINSPKLRTQIEDALIKADLNVYDKPTPFLFGEDFSFYGQQLAPAYFVFIGTRNEDKGFVTGLHTSHLNFDEKVLINVVNFYENLLNNYKEV
What are the official names of this protein?
Uncharacterized hydrolase MW1286.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20 family.
Protein: RUVB_RICAH
Sequence: MTNILSPEKSDNDQELPIRPSYLQEFVGQQQIKENLSVFIKAAKSRNQHLDHTLFYGPPGLGKTTLAKIISNEIGGNFKSTSGPAILKAADLAAILTNLEKNDVLFIDEIHRLNTAVEEILYPAMEDFELDIIIGEGPAARSVKITLPKFTLIGATTRLGLLSNPLRDRFGIPMRLNFYNTEELKKVLNRASKLFDIDLTDSGSEEIAKRSRGTPRIALRLLRRIRDFAAVDGKSRVDKEISDFGLKRLEVDLIGLDSNDYRYLKFIADHYNGGPVGIETIAAALSEERDALEETIEPYLIQIGLLQRTPRGRVITIAAFEHLKMPIPNQSHHQFNIFNENE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YIHX_ECOLI
Sequence: MLYIFDLGNVIVDIDFNRVLGAWSDLTRIPLASLKKSFHMGEAFHQHERGEISDEAFAEALCHEMALPLSYEQFSHGWQAVFVALRPEVIAIMHKLREQGHRVVVLSNTNRLHTTFWPEEYPEIRDAADHIYLSQDLGMRKPEARIYQHVLQAEGFSPSDTVFFDDNADNIEGANQLGITSILVKDKTTIPDYFAKVLC
What is the function of this protein?
Catalyzes the dephosphorylation of alpha-D-glucose 1-phosphate (Glc1P) and, to a lesser extent, of other sugar phosphates (PubMed:16990279) (PubMed:25484615).  Has no activity with the beta form of Glc1P.  In addition, YihX has significant phosphatase activity against pyridoxal phosphate (PLP) and low beta-phosphoglucomutase activity (PubMed:16990279).
What are the official names of this protein?
Alpha-D-glucose 1-phosphate phosphatase YihX, Alpha-D-glucose-1-P phosphatase, Alpha-D-glucose-1-phosphatase, Haloacid dehalogenase-like phosphatase 4, HAD4.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. YihX family.
Protein: G1PDH_HALLT
Sequence: MFEKTTWIKLPRNVLVGHGVLDDLGEAVGELYLTGRPLIVTSPTPNDIAGDRVRAQFDDPATAVVEEASFEAVEKLTETAEAVDPGYLIALGGGKPIDIAKMAADHLGVGFVSVPTVASHDGIVSGRSSIPEGDTRHSVAADPPLAVVADTTLIADAPWRLTTAGCADIISNYTAVKDWRLARRLRNVEYSEYAGALSEMTAELLVENADMIRPGLEESAWVVVKALVSSGVAMSIAGSSRPASGAEHLISHQLDRSAPGRALHGHQVGVASIMTEYLHSGENGEWSAIRDALAALDAPTTAAELGLDDAELIAALTSAHEIRDRYTILQGGINEAAAIEVATATGVIDG
What is the function of this protein?
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P).  The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
What are the official names of this protein?
Glycerol-1-phosphate dehydrogenase [NAD(P)+], G1P dehydrogenase, G1PDH, Enantiomeric glycerophosphate synthase, sn-glycerol-1-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glycerol-1-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEPA_SALPK
Sequence: MKKTAIALLAWFVSSASLAATPWQKITHPVPGAAQSIGSFANGCIIGADTLPVQSDNYQVMRTDQRRYFGHPDLVMFIQRLSHQAQQRGLGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWSQAQLLRPQALDLVSRDGKHVVPSRWSSDIASLIKLAAQDNDVTRIFVNPAIKQQLCLDAGSDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPPGDGCGAELQSWFEPPKPGTTKPEKKTPPPLPPSCQALLDEHVL
What is the function of this protein?
Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands.  Likely plays a role in the removal of murein from the sacculus.
What are the official names of this protein?
Penicillin-insensitive murein endopeptidase, D-alanyl-D-alanine-endopeptidase, DD-endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M74 family.
What are the subcellular locations of this protein?
Periplasm.