PharMolix/UniProtQA huggingface dataset:
Protein: RECO_SALCH
Sequence: MEGWQRAFVLHSRPWSETSLMLDVFTEESGRVRLVAKGARSKRSNLKGALQPFTPLLLRYSGRGEVKTLRSAEAVSLALPLSGITLYSGLYINELLSRVLEYETRFSELFFDYLNCIQALAGTTGSPEPALRRFELALLGHLGYGVNFTHCAGSGERVDDTMTYRYREEKGFFASVVIDNNTFTGRHLKALEAREFPDVDTLRAAKRFTRMALKPYLGGKPLKSRELFRQFMPKRTVKTKKD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RB11D_LOTJA
Sequence: MGGYRTDDEYDYLFKLVLIGDSGVGKSNLLSRFTKNEFNLESKSTIGVEFATKTLNVDAKVVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDVTRRATFENAARWLKELRDHTDPNIVVMLIGNKSDLRHLVAVPTEDGKSFAERESLYFMETSALEATNVENAFTEVLTQIYRIVSKRAVEAGDSGSSSGLPSKGQTINVKEDSSVLKRFGCCST
What are the official names of this protein?
Ras-related protein Rab11D.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: AFAP1_MOUSE
Sequence: MEELIVELRLFLELLDHEYLTSTVREKKAVLTNILLRLQSSKGFEVKDHAQKAEANNLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCSITYIPRDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDPECSPPPSTSAPVNKAELEKKLSSERPSSDGEGGVENGVTTCNGKEQAKRKKPSKSEAKGTVSKVTGKKITKIIGLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDSKLILHKDRADLKTHLVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPGALHYDYIDVEMSANVIQTAKQTFCFMNRRAVSTSPYLGSLSNGYAHPSGTALHYDDVPCVNGSLKNKKPPASSNGVPVKGKAPSSQQKKVETAGGVKRTASNAEQYKYGKNRVEADAKRLQSKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKTQAALEDKLKRLEEECKQREAERVSLELELTEVKESLKKALAGGVTLGLAIEPRSGTSSPQSPVFRHRTLENSPISSCDTSDAEGPLPVNSAAVLKKSQPSSGSSPCRGHVLQKAKEWELKNGT
What is the function of this protein?
Can cross-link actin filaments into both network and bundle structures.  May modulate changes in actin filament integrity and induce lamellipodia formation.  May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton (By similarity).
What are the official names of this protein?
Actin filament-associated protein 1, 110 kDa actin filament-associated protein, AFAP-110.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, stress fiber.
Protein: ATPG_METEP
Sequence: MPSLKDLRNRITSVKATQKITKAMQMVAAAKLRRAQNAAENGRPYAERMAQVLGNLAGNLIGGVGAPRLLTGTGQDRVHLLVVCTGDRGLAGAFNSSIARLARDHANRLMADGKTVKIITIGKKGLDVLRRQFRDQIIASRDIRGNKPVDYPFAAEIADDILARFEAGEFDVATLFYSEFRSVISQIPTAQKLIPAELPTAEGAAATGAGSDAAMEFEPNEETILETLLPKNLTVQIFRALLENAASEQGARMSAMDSATRNAGEMIKKQTLIYNRTRQAMITKELIEIISGAEAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SRP54_METS5
Sequence: MLDGIRDAVRKFLGGNTSYEVAVEEFIKDIQKALISSDVQVKLVFSLTNKIKERLKKETPPSNLERREWFIKIVYDELSALFGGDKEPEVNPKSIPWVIMLVGVQGTGKTTTAGKLAYFYKKRGYKVALVGADVYRPAALEQLQQIGKQINVPVYGEPGSQDAVGIAKRGVEKFLSERYELVIVDTAGRHGYGEEVKLLEEMKDIYEKIKPNEVILVIDASLGQKAYDLAKRFHEASNVGSIIITKMDGTAKGGGALSAVAATGAPIKFIGVGEKIDELEVFNPRRFVARILGMGDLEAIIEKMKAMEDYEGIQKKMGEVMTGKSKLTLRDMYKQIVAVRKMGPLSKILQLIPGMNMMGDIPEDQVKVGEQKMQRWLSIMNSMTYQELDNPSIIDKQRMRRIAMGSGTEVEEVRELIEHFNTVQRTLKMLKRRKKDVEKLFGQMGG
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes.  The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
What are the official names of this protein?
Signal recognition particle 54 kDa protein, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane.
Protein: BDEF_TACTR
Sequence: MKGNIGIAVFYMLLLLLPTDSIGKKMEEEQEKLFRQKRNPLIPAIYIGATVGPSVWAYLVALVGAAAVTAANIRRASSDNHSCAGNRGWCRSKCFRHEYVDTYYSAVCGRYFCCRSR
What is the function of this protein?
Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro.
What are the official names of this protein?
Big defensin.
What is the protein family that this protein belongs to?
Belongs to the big defensin family.
What are the subcellular locations of this protein?
Secreted. Note=L- and S- granules.
Protein: ENGB_SHIBS
Sequence: MTNLNYQQTHFVMSAPDIRHLPSDTGIEVAFAGRSNAGKSSALNTLTNQKSLARTSKTPGRTQLINLFEVADGKRLVDLPGYGYAEVPEEMKRKWQRALGEYLEKRHSLQGLVVLMDIRHPLKDLDQQMIEWAVDSNIAVLVLLTKADKLASGARKAQLNMVREAVLAFNGDVQVETFSSLKKQGVDKLRQKLDTWFSEMQPVEETQDGE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: SFSA_SALPB
Sequence: MLFSPPLQRATLIQRYKRFLADVITPDGTTLTLHCPNTGAMTGCATPGDTVWYSTSENTKRKYPHTWELTETQSGAFICVNTLRANQLTKEAIQENRLPALAGYNILKSEVKYGAERSRIDFMLQADFRPDCYIEVKSVTLAEKENGYFPDAITERGQKHLRELMGVAAAGHRAVVVFAVLHSAITRFSPARHIDIKYAQLLSEAQNKGVEVLAYKAELSAQKMELNEPVPITL
What is the function of this protein?
Binds to DNA non-specifically.  Could be a regulatory factor involved in maltose metabolism.
What are the official names of this protein?
Sugar fermentation stimulation protein A.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: NUOI_PARL1
Sequence: MAWLDQSARSLFLAEFVSSFLLAMRYFFKPKVTLNYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPALAITIEAGPRRNDGTRRTTRYDIDMTKCIYCGLCQEACPVDAIVEGPNFEFATETREELMYDKNRLLANGDRWEREIAKNIALDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL11_ENT38
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTESLEKGLPTPVVITVYADRSFTFITKTPPAAVLLKKAAGIKSGSGKPNKDKVGKISRTQLQEIAQTKAADMTGSDIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: MAP1_CLOAB
Sequence: MIIIKNDTEIEYMRQAGKIVGETLNMLEKAAKPGVTTADLDRLAEDFIKKYNAIPSFKGYGGFPASICTSINEEVIHGIPSKHRVLHEGDIISVDCGAILNGYQGDAARTFAIGEISEEAAKLIKVTKESFFKGVEKAVIGNRLTDISHSIQEYVESFGYGVVRDYVGHGIGKEMHEDPEVPNYGRPGRGPKLVHGMVLAIEPMVDVGTYMVKTQSNDWTVVTQDGSLAAHYENTVAILDNGPEILTLCE
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: KDSA_SODGM
Sequence: MKHLVVNIGDIQAANDLPFVLFGGMNVLESRDLAMRICEHYVTVTEKLGIPYVFKASFDKANRSSIHSYRGPGLDEGMKIFSELKAQFGVKVITDVHEAGQAQSVADVVDVIQLPAFLARQTDLVEAMARTGAVINVKKPQFISPGQVGNIVDKFREAGNHQVILCDRGSNFGYDNLVVDMLGFNVMKQVSGGCPVIFDVTHALQTRDPFGAASGGRRAQVSELARAGMAVGIAGLFIEAHPDPANAKCDGPSALPIAKLEPFLRQMKAIDELVKSFPELDTGH
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMD_COLP3
Sequence: MANYFKAAVKPKTSNQRLTVTVDKLDMNGVGVARWQNKPIFIAGVLPDEIVDVKVIEQKSKYARAKLISIDKQSASRVIPQCQHFGLCGGCDLQMLALEEQLLFKQQKITDLFSRSFSTQNITPEINTAHLPWQAAIKSSPWHYRRKARIGVQFDKNAQATIGFRQKSTNQLAAIKSCPVLVEPLSAIFPLLKKLLAQLTVKSAIGHIEVIQADISDTSSADKIQKDNQVVVVVRQLKPMNDTDIGLWQLYAQRHCWHVIIDDGNKQLPLADIKGGDSFELSYELTDTSKVYFSSNDFIQINHQVNNAMISQALAWLNILATDNVLDLFCGLGNFSLALAKHAKRVVGVEGMQTMVDKATQNSLVNGLDNCQFYQADLNSHWLLEPWVQGQVFDKVLLDPARAGAEQAVSQIAELKIPCVLYVSCDPATLARDSAILVSKGYKLEKISLMDMFSQTKHVETMILFTHTS
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: Y06Q_BPT4
Sequence: MNTLKKIVEFIRTKLGSAMAKNLSVEEQYTAAAAKLLDKIKDLKTASVKSINEEKRIRELIVEKNKQAESKEREIRKLLSEGQDVTMHAKLGLLYRRTAEQLTTKADGYAEMRIEIAKKVVELDDARQELAVKLEYIRETRAANALGISTADDVVEIAALTKVDIEDTLARVETFNGNISGVETTSADVQEYINSLK
What are the official names of this protein?
Uncharacterized 22.0 kDa protein in e-segB intergenic region.
What is the protein family that this protein belongs to?
To E.coli yfdP.
Protein: SPED_CITK8
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPQLIDKTEHPGPLPEAVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGMKHFIDHEINSIQNFMSDDMKSLYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTETERKEITAALWKEMREIYYGRNIPAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: ATPF_BACFR
Sequence: MSLLLPDSGLIFWMLLSFGIVFAVLAKYGFPVIIKMVEGRKTYIDESLEVAREANAQLSRLKEEGEAIVAAANKEQGRIMKEAMQEREKIIYEARKQAEIAAQKELDEVKRQIQIEKDEAIRDIRRQVALLSVDIAEKVIRKNLDDKQEQMGMIDRMLDEVLTKN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MRAZ_MYCGE
Sequence: MLLGTFNLTLDNKNRISLPAKLRSFFDSSIVINRGFENCLEIRKPADFESYFQTFNNFPNTQKDTRTLKRLIFANANLVELDSANRILIPNNLISDAKLDKEIVLIGQFDHLEVWDKVQYEQYLASSESLETVAERMKDAK
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PMA5_ARATH
Sequence: MSELDHIKNESVDLVRIPMEEVFEELKCTKQGLTANEASHRLDVFGPNKLEEKKESKLLKFLGFMWNPLSWVMEVAALMAIALANGGGRPPDWQDFVGIVCLLLINSTISFIEENNAGNAAAALMAGLAPKTKVLRDNQWSEQEASILVPGDVISIKLGDIIPADARLLDGDPLKIDQSSLTGESIPVTKNPSDEVFSGSICKQGEIEAIVIATGVHTFFGKAAHLVDNTNQIGHFQKVLTSIGNFCICSIALGIIVELLVMYPIQRRRYRDGIDNLLVLLIGGIPIAMPSVLSVTMATGSHRLFQQGAITKRMTAIEEMAGMDVLCCDKTGTLTLNKLTVDKNLVEVFAKGVGKEHVFLLAARASRIENQDAIDAAIVGMLADPKEARAGVREVHFFPFNPVDKRTALTYVDSDGNWHRASKGAPEQILNLCNCKEDVRRKVHGVIDKFAERGLRSLAVARQEVLEKKKDAPGGPWQLVGLLPLFDPPRHDSAETIRRALNLGVNVKMITGDQLAIGKETGRRLGMGTNMYPSSALLGQVKDSSLGALPVDELIEKADGFAGVFPEHKYEIVHRLQQRNHICGMTGDGVNDAPALKKADIGIAVVDATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMFIALIWQFDFSPFMVLIIAILNDGTIMTISKDRMKPSPQPDSWKLRDIFSTGVVLGGYQALMTVVFFWVMKDSDFFSNYFGVRPLSQRPEQMMAALYLQVSIISQALIFVTRSRSWSYAECPGLLLLGAFVIAQLVATFIAVYANWSFARIEGAGWGWAGVIWLYSFLTYIPLDLLKFGIRYVLSGKAWLNLLENKTAFTTKKDYGKEEREAQWAAAQRTLHGLQPAEKNNIFNEKNSYSELSQIAEQAKRRAEVVRLREINTLKGHVESVVKLKGLDIDTIQQHYTV
What is the function of this protein?
The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport.  The resulting external acidification and/or internal alkinization may mediate growth responses (By similarity).
What are the official names of this protein?
ATPase 5, plasma membrane-type, Proton pump 5.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RPOA_BACFR
Sequence: MAILAFQKPDKVLMLEADAKFGKFEFRPLEPGFGITVGNALRRILLSSLEGFAITTIRIEGVEHEFSSVPGVKEDVTNIILNLKQVRFKQVVEEFESEKVSITIENSSEFKAGDIGKYLTGFEVLNPELVICHLDSKATMQIDITINKGRGYVPADENREYCTDVNVIPIDSIYTPIRNVKYAVENFRVEQKTDYEKLVLEITTDGSIHPKEALKEAAKILIYHFMLFSDEKITLESNDVDGNEEFDEEVLHMRQLLKTKLVDMDLSVRALNCLKAADVETLGDLVQFNKTDLLKFRNFGKKSLTELDDLLESLNLSFGTDISKYKLDKE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: TRPD_POLSJ
Sequence: MPHTHKITPQEALQRTIEHREIFHDEMLHIMRLIMSGEMSPVMMAALITGLRVKKETIGEITAAAQVMREFSTKVHVADKTHLVDIVGTGGDGSHTFNISTCSMFVAAAAGAKVSKHGGRSVSSKSGSADVMEALGININLMPEAIAKCIEEAGVGFMFAPNHHPAMKNVAPIRKELGVRTIFNILGPLTNPASAPNILMGVFHPDLVGIQIRALQRLGAEHALVVYGKDGMDEVSLGAATIVGELKNGEITEYEIHPEDFSMTMASNRALRVETPEQSKAMLLGVLDNQPGAARDIVILNAGAALYAANVASSMQEGIVKARAALESGAAKARLAQLVSITQTLAA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: Y031_CHLTR
Sequence: MARKDRLTNERLNKLFDSPFSLVNYVIKQAKNKIARGDVRSSNVAIEALNFLDLYGIQSEYAERDDRERHLSATGERRREQGFGTSRRKDPSLYNWSDVK
What are the official names of this protein?
Uncharacterized protein CT_031.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0121/CT_031/TC_0300 family.
Protein: SYA_HYDCU
Sequence: MTSAELRKAFLDFFVKQGHTAVHSSPVVPGNDPTLLFTNAGMVQFKETFLGQETREYKRATSVQRCIRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKREAIQYAWTFLTEELGLPEEKLWITVFEEDREAEDIWLKEMGVSAERFSRCGAKDNFWSMGDTGPCGPCSEIFYDHGADVAGGPPGSPDEDGDRYIEIWNLVFMQFDRSEDGTLTPLPKPSVDTGMGLERLAAVMQNQHNNYDIDLFQAIVKKASELTGEKDLANSSLRVIADHIRSCAFMVVDGVLPSNEGRGYVLRRIIRRAIRHGYKLGQTDIFFYQLVPTLVEQMGEAYPELVKEQANVERALKLEEERFAETLENGMKILEEDIAQLSGSVISGSTAFKLYDTYGFPLDLTADVARERNLSVDEAGFEQEMEAQRARARSASNFGAQSKNKVDYTGSTHFIGYEQDEAEAEIAAIFVDNVSVEKASEGQEAIVILNQTPFYAESGGQVGDQGSLTEGMNSFHVDNCQKQGAAFLHIGKVTAGSISVGQTILAHIDVKARRASERNHSATHLLHAALRTVLGTHVGQKGSLVQPERLRFDFSHFEPISAEQLLEIEQLVNHNIMLNAQVMMEEMDIEAAKAKGAMALFGEKYGDVVRVVDMGDFSIELCGGTHVNWTGEIGPFRITSESGIASGVRRIEAVTGEAAWQTIYDMEKSLLNIAANLKTDKPQVESKVAQLVTEQKELEKQLKQLQSKLASSQGDDLASSVTEVNGVNVLAAELEGADVNTLRETLDKLRDKLEPAAIVLAAVDGDKVSLVAGVSKSITGNVKAGELVNHVAQQVGGKGGGRPDMAQAGGKDPSKLKEALASVKEWVATVA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TLL_DROME
Sequence: MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI
What is the function of this protein?
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity.  This receptor binds to the consensus sequence [AG][AG]AAGTCAA.  Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo.  It may also play a role in the nervous system.  The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains.  Involved in the regulation of early eye development.  In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate.
What are the official names of this protein?
Protein tailless, Nuclear receptor subfamily 2 group E member 2.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDK4_MOUSE
Sequence: MKAARFVMRSASSLSSASLVPREVELFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPDRLVNTPSVQLVKSWYIQSLMDLVEFHEKSPEDQKALSEFVDTLVKVRNRHHNVVPTMAQGILEYKDTCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNPSHIGSIDPNCDVVAVVQDAFECAKMLCDQYYLTSPELNLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENRPSLTPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEKLAV
What is the function of this protein?
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2.  This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate.  Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation.  Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade.  Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation.  In the fed state, mediates cellular responses to glucose levels and to a high-fat diet.  Regulates both fatty acid oxidation and de novo fatty acid biosynthesis.  Plays a role in the generation of reactive oxygen species.  Protects detached epithelial cells against anoikis.  Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
What are the official names of this protein?
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, Pyruvate dehydrogenase kinase isoform 4.
What is the protein family that this protein belongs to?
Belongs to the PDK/BCKDK protein kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: OPT_BOVIN
Sequence: MKLLALLSLLILMLQEARTASLSEEREGDPYAILHLGDYVLSLDNYDEVIDPSNYDELIDYGDQLPQVKGTSLASLTRTRFTQSTEAARTLPSNPTTARPPTLGLLAAPANHGLPTCLICVCLGSSVYCDDADLENIPPLPQTTAYLYARFNRISHIRAGDFKGLTKLKRIDLSGNSISSIDDKALRLLPALRDLILPENKLVALPTLPTSIEVLDVRMNRLQSSGIQPEAFRALEKLQFLYLADNLLDAIPPSLPLSLRSLHLQNNMIETMQRDAFCDAEEHRHTRRPLEDIRLDGNPINLSLFPSAYFCLPRLPTGRFV
What is the function of this protein?
Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity).  Binds collagen fibrils (PubMed:12951322, PubMed:10636917).  May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).
What are the official names of this protein?
Opticin, Oculoglycan.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: GCP2_HUMAN
Sequence: MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTPEDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQYLQQNAKERAELAAAAVGSSTTSINVPAAASKISMQELEELRKQLGSVATGSTLQQSLELKRKMLRDKQNKKNSGQHLPIFPAWVYERPALIGDFLIGAGISTDTALPIGTLPLASQESAVVEDLLYVLVGVDGRYVSAQPLAGRQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRFIEEKSSFEYGQVNHALAAAMRTLVKEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRTMDILASLATSVDKGECLGGSTLSLLHDRSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHELRKERIQEDYNDKYWDQRYTIVQQQIPSFLQKMADKILSTGKYLNVVRECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDLAEEELRKPVEDITPPRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAMAHADPTELALSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNIDDVLGHHTGFLDTCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDGELGGQTLEHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLLDLLARLSIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKATPQVPVLRGPPAPAPRVAVTAQ
What is the function of this protein?
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.  Plays a role in neuronal migration.
What are the official names of this protein?
Gamma-tubulin complex component 2, GCP-2, hGCP2, Gamma-ring complex protein 103 kDa, h103p, hGrip103, Spindle pole body protein Spc97 homolog, hSpc97.
What is the protein family that this protein belongs to?
Belongs to the TUBGCP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.