Protein: BUB1_CAEEL
Sequence: MSHIRVAFAPLDTNPSTCGLETFATQIETLSQMMTAEEMKAELYDCVRRILREQKFDQIRENEAMLRLYKVMGRSSTNLKGRGIYEQLFKKDHFTGSLKFYLQWAEECGKDQMLEEFKDVLKLARDRLSERIEMTAIESGFRDLVDEYFNGESGDMFTRPDETMDLFRFNAGSKKKRRSSVCFLQHNVPINNSGKAAFGPKTKTDLRQACIDRPNYHGISIEEFRFAKWKDTFGEDVDDDYRKRKDSGVVFVKHQVIDTDRQAREEVENRFNANLNPRRRHLSPVSEKTVDDEEEKRSRIYSPLVATKDAHRPALRSKIENPPATVTLSSDTKSASEKDVSDSDDADDDERLKIMTAGRKDGNPPDRSTSISSNYSTASARTSKSGAGLDLMAENKCLEAHAMFSDTVHLASEKTMVLGDDSVFVPERSLATTQIVTDFSVLCDPDPTMTITQERPKKVSNGLNVVYDEAAEPEESQKVEESEVQPEIVLVSPVTQTSPATMFNDIYDDEIEFGFFKPSRGNFVTSTPAQGVHLVNIDEYFGNKEEESTHEQEAPVFVAPTSSTFSKLTRRKSLAANQAVQPSVTESSKPERSDPKDSSIDCLTANLGRRLSIGADEIPNLTENNESEITGCKIRRRSEIIKQGDINPWDETLRKKLMCLVRPPQNMHEFQERAPKIQALRDCEVSGEKLHIQTLIGQGGYAKVYRAVTDDQRTVAVKYEVPSCSWEVYICDQMRNRLKDRGLELMAKCCIMEVMDAYVYSTASLLVNQYHEYGTLLEYANNMKDPNWHITCFLITQMARVVKEVHASKIIHGDIKPDNFMITRKIDDKWGKDALMSNDSFVIKIIDWGRAIDMMPLKNQRFKGRAGTEAFDCPEMVDGRSWTYQADYFGFAATMAVVVAGKYAQLTGASVGDYSLNVDIKRRNILRDACYDVINRFLNIPSCDSLPDWNILIKSFSEIWNEKFEASGWRQAVSKFNEACDLAANQK
What is the function of this protein?
Serine/threonine-protein kinase essential for spindle-assembly checkpoint signaling.  Plays a key role in the recruitment of the checkpoint proteins bub-3, mdf-1 and mdf-2 to unattached kinetochores (PubMed:18936247, PubMed:19109417, PubMed:24567362, PubMed:25987605).  mdf-1 recruitment is independent of bub-1 kinase activity (PubMed:24567362).  Has a role in the correct kinetochore localization of the spindly-like protein spdl-1 (PubMed:18765790).  In addition, during meiotic anaphase I, controls the recruitment of hcp-1/2 and klp-19 to the ring-shaped domain formed between chromosomes (PubMed:20729837).  Involved in chromosome alignment, chromosome homolog segregation and spindle assembly (PubMed:20729837, PubMed:25987605).  In association with bub-3 at the kinetochore region of chromosomes, promotes the onset on anaphase independently from spindle checkpoint signaling and promotes the formation of stable end-on bipolar attachments of chromosomes (PubMed:25987605).  Plays a role in nuclear envelope breakdown (PubMed:19109417).  Required maternally during embryogenesis and in the zygote for the postembryonic development of several tissues including ventral cord neurons, gonad, intestine and seam cells (PubMed:19526056).
What are the official names of this protein?
Mitotic checkpoint serine/threonine-protein kinase bub-1, Budding uninhibited by benzimidazole 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores during prophase and metaphase. In metaphase, localizes also to a matrix-like structure around the spindle (PubMed:11402065). In anaphase, localizes only to unattached kinetochores which is kln-1-dependent (PubMed:11402065, PubMed:24567362). Localizes also in a ring-shaped domain between kinetochores, during anaphase of meiosis I which is air- 2 and kln-1-dependent and between sister chromatids during meiosis II, which is kln-1-independent (PubMed:20729837). Localization to the kinetochore is dependent on bub-3 and on knl-2 (PubMed:25987605, PubMed:17339379).