PharMolix/UniProtQA huggingface dataset:
Protein: MRAY_SALSV
Sequence: MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIARLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLIGYGIIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLVGKDTPATQLVVPFFKDVMPQLGLFYILLSYFVIVGTGNAVNLTDGLDGLAIMPTVFVAAGFALVAWATGNMNFANYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LEUC_GLAP5
Sequence: MKKTLYEKLFDAHVVHEAEGETPLIYINRHLVHEVTSPQAFDGLRAMGREVRQPTKTVATMDHNVPTDSRDLGGSGEMGRIQMVELAKNTEQFGVTLYDINHINQGIVHVMGPEQGLTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTVKQARAKKMKIEVRGKVREGITAKDIVLAIIGKTTMAGGTGHVVEFCGEAIRDLSMEGRMTVCNMAIELGAKSGLIAPDETTFAYLKDRPSAPKGKDWDDAVAYWKTLHTDEGAEFDTVVTLEASEIEPQVTWGTNPGHVIGINETIPNPADMADPIERQSAEKALAYMGLPHSIKLTDVAIDKVFIGSCTNSRIEDLRAAAAVAKGRKVADGVQALVVPGSGLVREQAEKEGLDKIFIEAGFEWRQPGCSMCLAMNNDRLEPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVHGKFVDIRNVELH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: ILVE_RICBR
Sequence: MTKNSENNLWYIWINGELVPYELATVHALTHSLHYSGSVFEGERAYNGKVFKLKEHTERLVKSAEVLGLKVPYNVEEIIKAHELLIEKNKIQDAYIRPLVWCGSESLNIINPKLSTNVLIAAVPSMPRAFAAGFNLYVSRWRKAAPNMMPVQSKSAAHYNMAITSKKEAKDLGYDDALLLDYEGYIAECTTTNIFFVKDNVLYTPIADRFLDGITRQTIIEIAKNLGLEVKEERLKLEQIEDFISCFATGTAIEVQNINSIDIGNKKVIFNDHKIADVLKEEYGKIVRG
What is the function of this protein?
Acts on leucine, isoleucine and valine.
What are the official names of this protein?
Probable branched-chain-amino-acid aminotransferase, BCAT.
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Protein: GLYA_MANSM
Sequence: MLQNHSIAEFDPVLWDAIQNENRRQEEHIELIASENYVTKAVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANAAVYGALLNAGDTILGMDLAHGGHLTHGAKVSFSGKIYNSVLYGITAEGLIDYEDVRVKALESKPKMIVAGFSAYSQVVDWAKMREIADEVGAYLFVDMAHVAGLIAAGLYPNPLPHAHVVTTTTHKTLAGPRGGLILSACGDEEIYKKLNSSVFPANQGGPLMHVIAAKAVCFKEALQPEFKAYQAQVLKNAKAMVEVFKQRGFEVVSKGTENHLFLVSFVKQGLTGKAADAALGEANITVNKNSVPNDPQKPFITSGIRVGSPSITRRGFNEADASTLAGWMCDVLESIGKDNYDQVIAETRAKVLEICKRLPVYGD
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU3_STRCO
Sequence: MSKTAYVRTKPHLNIGTMGHVDHGKTTLTAAITKVLAERGAGSTTQYVSFDRIDRAPEEAARGITINIAHVEYETDTRHYAHVDMPGHADYVKNMVTGAAQLDGAILVVSALDGIMPQTAEHVLLARQVGVDHIVVALNKADAGDEELTDLVELEVRELLTAHGYGGDAVPVVRVSGLKALEGDPRWTASVEALLDAVDTYVPMPERYLDAPFLLPVENVLTITGRGTVVTGAVERGTVRVGDRVEVLGASVETVVTGLETFGKPMEEAQAGDNVALLLRGVARDTVRRGQVVAAPGSVVPARRFRARVYVLSAREGGRSTPLTTGYRPQFYIRTADVVGDVDLGEEAVARPGDTVTMTVELGRDVPLETGLGFAIREGGRTVGAGTVTAVE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu-3, EF-Tu-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_LISMF
Sequence: MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRVVFVNKMDKIGADFLYSVGTLHERLAANAHPIQLPIGAEDTFEGIIDLIEMNALYYEDDLGNDPHIKEIPADLKDLADEYRGKLVEAVAELDEELMMKYLEGEEITKEELKAGIRKGTLNVEFYPVVCGTAFKNKGVQPMLDAVLDYLPAPTDVPAINGVLPDGEEAARHADDSEPFSSLAFKVMTDPYVGRLTFFRVYSGTLNSGSYVQNSTKGKRERVGRILQMHANHREEISIVYAGDIAAAVGLKDTTTGDTLCDEKEQIILESMEFPEPVIQVAIEPKSKADQDKMGQALAKLAEEDPTFRAETDQETGQTLISGMGELHLDILVDRMRREFRVEANVGDPQVSYRETFRKSAQVEGKFVRQSGGRGQYGHVWIEFGPNEEGKGFEFENAIVGGVVPREYIPAVQAGLEGALDNGVLAGYPLIDIKAKLYDGSYHDVDSNEMAFKVAASMALRNAAKKCDPVILEPMMAVEVVIPEEYLGDIMGNITSRRGRVDGMEARGNAQVVRAFVPLANMFGYATHLRSGTQGRGVYTMQFDHYEEVPKSIAEEIIKANGGNNKED
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_STAA3
Sequence: MNYLNKIRIENPLTICYTNDVVKNFTANGLLSIGASPAMSEAPEEAEEFYKVAQALLINIGTLTAENEQDIIAIAQTANEAGLPIVFDPVAVGASTYRKQFCKLLLKSAKVSVIKGNASEILALIDDTATMKGTDSDANLDAVAIAKKAYATYKTAIVITGKEDVIVQDNKAFVLANGSPLLARVTGAGCLLGGVIAGFLFRETEPDIEALIEAVSVFNIAAEVAAENENCGGPGTFSPLLLDTLYHLNETTYQQRIRIQEVE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: IF5A_METVS
Sequence: MAGTKPGDLGQVKVGQYVVIDGIACRVMDTAHSKPGKHGGAKVRMVAVGIFEPVKKEYVGPAGSRIDIPLIDKRKGQVLALMGDQVQIMDMESFETLEIPMPEDVEGIESGAEVEYFEAMDRYKITRVIGK
What is the function of this protein?
Functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Translation initiation factor 5A, Hypusine-containing protein, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_SYNP2
Sequence: MRADWVAKRQGQSNVSQMHYARQGVITEEMDYVAKRENLPVDLIRDEVARGRMIIPANINHTNLEPMCIGIASKCKVNANIGASPNSSEINEELAKLQQAVKYGADTVMDLSTGGGNLDEIRTAIIKASPVPIGTVPIYQALESVHGNMENLTANDFLHIIEKHAQQGVDYMTIHAGILIEHLPLVKNRITGIVSRGGGILARWMLHHHKQNPLYTHFDDIIEIFKRYDVSFSLGDSLRPGCTHDASDEAQLAELKTLGQLTRRAWEHDVQVMVEGPGHVPMDQIEFNVKKQMEECSEAPFYVLGPLVTDIAPGYDHITSAIGAAMAGWYGTAMLCYVTPKEHLGLPDAEDVRNGLIAYKIAAHAADIARHRPGARDRDDELSHARYNFDWEKQFELSLDPERAREYHDETLPADIYKTAEFCSMCGPKFCPMQTKVDADALTELEKYLASTAAKEELAKA
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: VNPA_OXYSC
Sequence: SDSKIGDGCFGLPLDHIGSVSGLGCNRPVQNRPKK
What is the function of this protein?
Exhibits vasoactive (PubMed:15652496) and hypotensive activity (By similarity).  Is only weakly active on natriuretic peptide receptor-C (NPR3).
What are the official names of this protein?
Natriuretic peptide TNP-a, Taipan natriuretic peptide, Venom natriuretic peptide OxsSNPa.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL32_MOOTA
Sequence: MGVPKRRTSKARKNKRRSIWGQMAAPTLVECPQCHQLKLNHRVCPKCGYYKGREAIQVAE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: PFDA2_THEKO
Sequence: MAEEKKTRTLEQIQDEIRSYLGEIEYLRSQVGVIDATITDLRTVDATLAYLKEKGKGKEIYIPLGSGVAIRGKIENPDDVIMDVGAGILVGATVDEARENIEKRIKALMDLRLALLRKIEEDTRKVNELLKELQEMQPEKRE
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit alpha 2, GimC subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CADD_CHLMU
Sequence: MESRKGIKEVSMNFLDQLDAIIQNKHMLEHPFYMKWSKGELTKEQLQAYAKDYYLHIKAFPKYLSAIHSRCDDLEARKLLLDNLMDEENGYPNHIDLWKQFVFALGVSSEELEAHEPSEAAKAKVATFMRWCTGDSLAAGVAALYSYESQIPCVAKEKIRGLIEYFGFSNPEDYAYFTEHEEADVRHAREEKALIEMLSRDDSDKVLEASREVTQSLYGFLDSFLEPATCCHCHKA
What is the function of this protein?
Involved in de novo para-aminobenzoate (PABA) biosynthesis.  Acts as a self-sacrificing or 'suicide' enzyme that utilizes its own active site tyrosine residue(s) as the substrate for PABA synthesis.  The side chain of the tyrosine residue is released from the protein backbone via cleavage of the C(alpha)-C(beta) bond, leaving a glycine in place of the original tyrosine residue.  Reaction requires O(2) and a reduced dimetal cofactor.
What are the official names of this protein?
4-aminobenzoate synthase, para-aminobenzoate synthase, PABA synthase.
What is the protein family that this protein belongs to?
Belongs to the CADD family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Note=Secreted into the host cytoplasm, where it co-localizes with Fas in the proximity of the inclusion body.
Protein: HTPX_NOSP7
Sequence: MGNQVKTAALLAALSGLLIAISYWVIGGSSGLIIGIGLAAVTNLFSWYQSDKIALAVYQAQPVSEGEAPGLYRMVQRLSDRANIPMPRVYIVPSQGANAFATGRDPEHAAVAVTEGILNILPDDELEGVIAHELTHIINRDTLTQAVAATVAGAISFLAQMVSYSLWFGGGSRDDNRGANPLGVLLTVMLAPLAATIIQLAISRTREFSADAGSARLTGNPRALARALQRLEALAKQIPLNANPAFEPLLIINSISGQFLGNLFSSHPATEARVAALLKLEQQLPTKAY
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FBLI1_PONAB
Sequence: MASKPEKRVASSVFITLAPLRRDVAMAEEVRQAVCEARRGRPWEAPAPMKTPEAGLEGRPSPWTPPGRAAATVPAAPMQLSNGGCPPPPPVLDGEDALPDLDLFPPPPPPPPVLLPSEEEAPAPMGASLIADLEQLHLSPPLPPPPPQAPAERPSVQPSPLRPMEEELPPPPAERVEKGASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRSFHENCYRCEDCRILLSVEPTDQGCYPLNNRLFCKPCHVKRSAAGCC
What is the function of this protein?
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments.  Is implicated in cell shape modulation (spreading) and motility.  May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments.  May also regulate the assembly of filamin-containing signaling complexes that control actin assembly.  Promotes dissociation of FLNA from ITGB3 and ITGB7.  Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity).
What are the official names of this protein?
Filamin-binding LIM protein 1, FBLP-1.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2.
Protein: LUTB_ANOFW
Sequence: MAMKINTGEFHERVEKGIHNTFMRGAVAGAQERLRTRRLEAAQELGNWEEWRALGEEIRQHTLENLDYYLMQLSENVKKRGGHVFFAQTAEEANDYICRVVASKQAKKIVKSKSMVTEEIHMNAALEKLGCEVIETDLGEYILQVDDHDPPSHIVAPALHKNKEQIRDVFQQKLAYTKTEKPEELALHARAMLRQQYLTADVGITGCNFAVAESGSITLVTNEGNADLVTALPKTQITVMGMERIVPTFEEMEVLVSLLTRSAVGQKLTSYITVLTGPREEGEVDGPEEFHLVIVDNGRSDILGTEFQPVLQCIRCAACVNVCPVYRHIGGHSYGSIYSGPIGAVLSPLLGGYDDYKELPYASTLCAACTEACPVKIPLHELLLKHRQTIVEREGKAPISEKLAMKAFGLGAASSLLYKLGSKIAPTAVNPFTTNDRISKGPGPLKAWTDIREFPAPEKERFRDWLKQRGNE
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.  Has probably a role as an electron transporter during oxidation of L-lactate.
What are the official names of this protein?
Lactate utilization protein B.
What is the protein family that this protein belongs to?
Belongs to the LutB/YkgF family.
Protein: SBT32_ARATH
Sequence: MTRALILVAICLMLTLNNAAETKVHIVYLGEKQHDDPDSVTESHHQMLWSILGSKEAAHDSMTPWLLSFRSQTNQFPSESTLRFYELQTTRTWDYLQHTSKHPKNILNQTNMGDQLIIGVVDSVTLNWFGFILLKQEYGQSLNHSVTMVLDQYQNVGKEVQLGHAENPEYISPRDFDGHGTHVAATAAGSFVPDTNYLGLGRGTARGGAPRARIAMYKACWHLVTGATTCSAADLVKAIDEAIHDGVDVLSISNGFSVPLFPEVDTQDGVAVGAFHAVAKGIPVVCAGGNAGPSSQTISNTAPWIITVAATTQDRSFPTFITLGNNVTVVGQALYQGPDIDFTELVYPEDSGASNETFYGVCEDLAKNPAHIIEEKIVLCFTKSTSYSTMIQAASDVVKLDGYGVIVARNPGHQLSPCFGFPCLAVDYELGTDILFYIRSTRSPVAKIQPTRTLVGLPVATKVATFSSRGPNSISPAILKPDIAAPGVNILAATSPNDTFYDKGFAMKSGTSMSAPVVAGIVALLKSVHPHWSPAAIRSAIVTTAWRTDPSGEPIFADGSNRKLADPFDYGGGVVNSEKAANPGLVYDMGVKDYILYLCSVGYTDSSITGLVSKKTVCANPKPSVLDLNLPSITIPNLAKEVTITRTVTNVGPVGSVYKPVIEAPMGVNVTVTPSTLVFNAYTRKLSFKVRVLTNHIVNTGYYFGSLTWTDSVHNVVIPVSVRTQIMQRYYDEN
What are the official names of this protein?
Subtilisin-like protease SBT3.2, Subtilase subfamily 3 member 2, AtSBT3.2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: UXUA_PHOPR
Sequence: MEQTWRWYGPNDPVSLNDIRQAGATGIVNALHHIPNGEVWTKEEILIRKALIEDKGLTWSVVESVPVHEEIKTQTGNYQLWIDNYKQTLRNLAECGIDTVCYNFMPVLDWTRTDLEFEMDDGSKALRFDQIAFAAFELHILKRPSAEGAYSDEEQAQAKIYFDNMSDADIAKLTGNIIAGLPGAEEGYTLQEFQAQLDLYDGITKDKLREHMVYFLKELMPICDANGLKMAVHPDDPPRPILGLPRIVSTIEDIDWLTAEVPSQMNGITMCTGSYGARGDNDLVNMIRQHGDRIYFTHLRSTQREDNQLSFHEAAHLDGDVDMYNVVMEILKEEQRRDDAGDVRLIPMRPDHGHQMLDDLNKKTNPGYSAIGRLKGLAEVRGLEMALKRAFFTK
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: CH10_SALHS
Sequence: MSIRPLHDRVIVKRKEVESKSAGGIVLTGSAAGKSTRGEIIAVGKGRILDNGTVQPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAG_AVISN
Sequence: MGQAGSKGLLTPLECILKNFSDFKKRAGDYGEDVDSFALRKLCELEWPTFGVGWPKEGTLDFKVVAAVRNIVFGNPGHPDQVIYITVWTDITIERPKYLKSCGCKPHRTSKVLLASQKVNPRRPVLPSAPESPPRIRRAQFLDERPLSPAPAPPPPYPEVSAIVEDTREGQQPDSTVMTSPPHTRSGLEFGAQGPSGMYPLRETGERDMTGRPMRTYVPFTTSDLYNWKNQNPSSFSQAPDQVISLLESVFYTHQPTWDDCQQLLRTLFTTEERERVRTESRREVRNDQGVQVTDEREIEAQFPATRPDWVGS
What is the function of this protein?
Forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex.
What are the official names of this protein?
Gag polyprotein, Core polyprotein.
What are the subcellular locations of this protein?
[Gag polyprotein]: Virion. Host cell membrane; Lipid-anchor. SUBCELLULAR LOCATION: [Matrix protein p15]: Virion. SUBCELLULAR LOCATION: [Capsid protein p30]: Virion.
Protein: PRKAA_XENLA
Sequence: MSQERFPAAPKMSSEKPTSLDAMRATNPCETPIQLLHEFGTKTGNHPVYTLEKAEGQAHNPSFTFRLVIGDITSLGEGPSKKTAKQKAAEFALNILRGDTSKCLPVTDTLRDPKKPPNQMQENPVGSLQELAVQKGWRLPEYTVAQESGPPHKREFTITCRVETFVETGSGTSKQVAKRVAAEKLLTKFKTISTDNIPLNKLIGNKMGCTWDSMRNSSGEKISMLKRSPLSIPNTDYVKMLKDVAEELDFNLTYLDIDELSVNGQYQCLAELSTNPITVCHGTGISCGNAHNDAAHNALQYLKIMCIKK
What is the function of this protein?
Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis.  Required for siRNA production by dicer1 and for subsequent siRNA-mediated post-transcriptional gene silencing.  Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity).
What are the official names of this protein?
Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog A.
What is the protein family that this protein belongs to?
Belongs to the PRKRA family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus.
Protein: THIO_HELPJ
Sequence: MSHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPVIDELASEYEGKAKICKVNTDEQEELSAKFGIRSIPTLLFTKDGEVVHQLVGVQTKVALKEQLNKLLG
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: GPN2_MACFA
Sequence: MAGAAPTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELVGLGDVMDALRLGPNGGLLYCMEYLEANLDWLRAKLDPLRGHYFLFDCPGQVELCTHHGALRSIFSQMAQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHINLLSKMDLIEHYGKLAFNLDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKLVQLIEDYSLVSFIPLNIQDKESIQRVLQAVDKANGYCFGAQEQRSLEAMMSAAMGADFHFSSTLGIQEKYLAPSNQSVEQEAMQL
What is the function of this protein?
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII).  May act at an RNAP assembly step prior to nuclear import.
What are the official names of this protein?
GPN-loop GTPase 2, ATP-binding domain 1 family member B.
What is the protein family that this protein belongs to?
Belongs to the GPN-loop GTPase family.
Protein: EBNA1_EBVA8
Sequence: MSDEGPGTGPGNGLGQKEDTSGPDGSSGSGPQRRGGDNHGRGRGRGRGRGGGRPGAPGGSGSGPRHRDGVRRPQKRPSCIGCKGAHGGTGAGGGAGAGGAGAGGAGAGGAGAGGAGAGGAGAGGAGAGGAGAGGAGAGGAGAGGGAGAGGAGAGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGAGAGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGAGAGGGGRGRGGSGGRGRGGSGGRGRGGSGGRRGRGRERARGGSRERARGRGRGRGEKRPRSPSSQSSSSGSPPRRPPPGRRPFFHPVAEADYFEYHQEGGPDGEPDMPPGAIEQGPADDPGEGPSTGPRGQGDGGRRKKGGWYGKHRGEGGSSQKFENIAEGLRLLLARCHVERTTEDGNWVAGVFVYGGSKTSLYNLRRGIGLAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFIVFLQTHIFAEGLKDAIKDLVLPKPAPTCNIKVTVCSFDDGVDLPPWFPPMVEGAAAEGDDGDDGDEGGDGDEGEEGQE
What is the function of this protein?
Responsible for the origin of replication (oriP) dependent replication and maintenance of viral episomes during latent infection.  EBNA1 dimer interacts with the DS (dyad symmetry) element within the origin of replication oriP and with a host mitotic chromosome to initiate viral DNA replication during latency.  EBNA1 binding to DS recruits the host origin recognition complex (ORC).  Governs the faithful mitotic segregation of the viral episomes by binding both the FR (family of repeats) element within oriP and the host mitotic chromosomes.  Forms a cell cycle-dependent tyrosine-dependent DNA cross-link and single-strand cleavage at oriP required for terminating replication and maintaining viral episomes.  Counteracts the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.  Induces degradation of host PML through the ubiquitin-proteasome system, which promotes lytic reactivation and may impair the host cell DNA repair.  Displays inhibitory effects on a SUMO2-modified complex that includes STUB1, KAP1 and USP7.  This inhibitory effect possibly participates to the maintenance of latency linked to PML silencing.
What are the official names of this protein?
Epstein-Barr nuclear antigen 1, EBNA-1, EBV nuclear antigen 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae EBNA1 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: G6PI_ALKMQ
Sequence: MSGIRFDYSKASGYINTHELDYLGKMTETAHQLLHEKTGAGNEFLGWLDLPKNYDQDEFQRVQNCAEKIKNDSDVLIVIGIGGSYLGSRAAIEMLTHTFHNSLPKDKRQGPEVYFAGHNISSTYLKHLLDIIEGKDISLNVISKSGTTTEPALAFRVLKEYMEKKYGKEETTKRIYATTDQAKGALKQLADEEGYESFIIPDDVGGRFSVLTAVGLLPIAAAGINIEEVMQGAKQALQDFNHSNIDKNSCYQYAIVRNALYRKGKTTEIMVNYEPALHYIGEWWKQLFGESEGKDQKGIFPASVSFSTDLHSMGQYIQEGMRNIFETVLHVENTQEKMIIQPTDADLDGLNYLAGKTVDFVNEKAFEGTLLAHTDGGVPNLIIHIPEITPYYFGYLVYFFEKACAISGYLLGVNPFDQPGVEAYKKNMFALLGKPGFEEAQRELQKRLEK
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END4_OCEIH
Sequence: MVKIGSHVSMNGKKMLLGSSEDAVQYGANTFMIYTGAPQNTRRKPIEELNIEAGTEHMKANGIQDIVVHAPYIINIGNSIKPATFELGVNFLKNEIDRTEALGAKQIVLHPGAHVGEGAEKGIPKIIEGLNEVLDPNSNVQIALETMAGKGSEIGRTFEELAQIIEGVTHNDRLSICMDTCHIHDAGYNIVEDFDGVLEQFDKIIGIDRLKVVHVNDSKNERGAHKDRHENIGFGYIGFEALHNIVHHPQLSDLPKILETPFVGTDKKNKKPPYKHEIEMLKEGNFDPHLKEKIMEA
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: REPA_MSVPA
Sequence: MASSSSNRSFLHRNANTFLTYPHCPENPEIISQKLWDLVARWNPLYIVCAREAHRDGNMHLHALLQTDKPVRTTDARIFDIEGFHPNIQSAKSVNKVRDYILKEPLAVFERGTFIPRKSCFQGNTPPFPKKNPNKDEIMAHIISHATSKQEYLCLVRKEFPYDWATKLQYFEYSANKLFPDIQEEFISPHPPSSPDLLCNESIKDWLQPNIYQVSPEAYMLLQPTCYTVDEAISDLTWMDNLSSQQMKDQESRASTSSVQQGQGNLLGPEV
What is the function of this protein?
Implicated in enhancement of V-sense gene expression.  Acts a an inhibitor of C-sense gene transcription (By similarity).
What are the official names of this protein?
Replication-associated protein A, RepA.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae Rep protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.