PharMolix/UniProtQA huggingface dataset:
Protein: CH601_STRLI
Sequence: MAKILKFDEDARRALERGVNKLADTVKVTIGPKANVVIDKKFGPPTITNDGVTIAREVEVEDPYENLGAQLVKEVATKTNDIAGDGTTTATVLAQALVREGLKNVAAGASPALLKKGIDAAVAAVSEDLLATARPIDEKSDIAAVAALSAQDQQVGELIAEAMDKVGKDGVITVEESNTFGLELDFTEGMAFDKGYRLRLLRTDQERMEAVLDDPYILINQGKISSIADLLPLLEKVIQANASKPLLIIAEDLEGEALSTLVVNQIRGTFNAVAVKAPGFGDRRKAMLQDMAVLTGATVISEEVGLKLDQVGLEVLGTARRITVTKDDTTIVDGPGKRDEVQARIAQIKAEIENTDSDWDREKLQERLAKLAGGVCVIKVGAATEVELKERKHRLEDAISATRAAVEEGIVSGGGSALVHAVKVLEGNLGKTGDEATGVAVVRRAAVEPLRWIAENPGLEGYVITSKVADLDKGQGFNAATGEYGDLVKAGVIDPVKVTRSALENPASIASLLLTTETLVVEKKEEEEPAAGGHSHLGHSH
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_ACTPJ
Sequence: MGKIIGIDLGTTNSCVAVMDGDKARVIENAEGARTTPSIIAYTDNETLVGQPAKRQAITNPKNTLFAIKRLIGRRFESEEVQRDIKIMPFEITRADNGDAWVNVKGDKLAPPQISAEVLKKMKKTAEDFLGEAVTEAVITVPAYFNDAQRQATIDAGRIAGLDVKRIINEPTAAALAFGLGSTKENQVIAVYDLGGGTFDISIIEIDNFDGEQTFEVLATGGNTHLGGEDFDNRVIDYIIDEFKKEQGVDLRNDPMALQRVKEAAEKAKIELSSAQSTEVNLPYITADATGPKHLAINVTRAKLEALVEDLVASSIESLKTVLKDAGKSVNEINDIILVGGQTRMPLVQQKVAEFFGKEARKDVNPDEAVAIGAAVQGGVLKGDVKDVLLLDVTPLSLGIETMGGVMTVLIEKNTTIPTKKSQVFSTAEDNQSAVTIHVLQGERKQASANKSLGQFNLEGINPAPRGMPQIEVTFDIDANGVINVSAKDKNTGKEQQIRIQASSGLSDEEIEQMVRDAEANAEADKKFEELVQARNQADGIAHATRKQIEEAGDALNADDKAKIEAAIADLEKAAKGDDKAEIDAKTEALIKASEPLMQAAQAKAQQAGGEQPQAKKDDGVVDAEFEEVKDNK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: HEPA_HHV8P
Sequence: MATSEETAAGYVIGVYFHSVHVHCRIIVWQVNFLPLDPNDGETECYFVVDTLTKEAMERMPEIQECVPSITEHARDLAIWELALRLQNQTIVKAVRTASLPVVLIMTVGRIVNDVIPCPNVRTPRPLACAYLHCEATVTFEVPLTGPAASTGTWHSSIYRECAISAIEICLKTSRGIYSCQSNEAPEAKREKRGLDISDVFVCLTYDIPIAGRVLSLLVPHAPAFHVLWINEDSKWNGAAVEFFRALHHKLFSERNGIPPLWLYVFPGAVEEGTAFAPLLPAFPCIPLRYGSPTSLDRASVQWDLFEPHILTHFDGIKRTSLADTVFGYDSLAISRECEDQYVWPTPVTDININLCTDSDTMAIVREPSGLVAVNLEALLRTDSVLSRVSSIVSLDTLLDLSTPECRRSVELRYNSLLSTVLSWSTSRGHKWAAIVKWKLFFLVQALEPEQWSPEFKDLKRACQMAGFTLKGGTSGDLVFSSHANLLFSTSMGYFLHAGSPRSTAGTGGEPNPRHITGPDTEGNGEHRNSPNLCGFVTWLQSLTTCIERALNMPPDTSWLQLIEEVIPLYFHRRRQTSFWLIPLSHCEGIPVCPPLPFDCLAPRLFIVTKSGPMCYRAGFSLPVDVNYLFYLEQTLKAVRQVSPQEHNPQDAKEMTLQLEAWTRLLSLF
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs.  The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
What are the official names of this protein?
DNA helicase/primase complex-associated protein, HEPA, Primase-associated factor.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HEPA family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: HTPX_BURP6
Sequence: MFNWVKTAMLMAAITALFIVIGGMIGGSRGMTIALLIALGMNFFSYWFSDKMVLRMYNAQEVDEATAPQFYRMVRELATRANLPMPRVYLIDENQPNAFATGRNPEHAAVAATTGILRVLSEREMRGVMAHELAHVKHRDILISTISATMAGAISALANFAMFFGGRDENGRPANPIAGIAVALLAPIAGALIQMAISRAREFEADRGGAQISGDPQALASALDKIHRYASGIPFQTAEEHPATAQMMIMNPLSGGGLQNLFSTHPATEERIARLMDMARTGRFD
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PALB_CRYNB
Sequence: MPFCSYQEGLKVASDLGNKAIQTEASLSSLSPVASPIPTLQKAFPIYISAAEAYGHLLSSKLVPQSDIETVKRKWRLVLERAEKVKSRIEQLGGHVAKAEIGDRGEEIAVLRRASLINGVAVELWRPPGDTFDAGEPYREAVQPELAAAQLDMDPEWRDIQADCWLHQAPNEGDWVMRQGPVSDCSVVAAMGVGIKHAGQFGTAFGWENLYPQDAHGRPRRSKNGKHILKLLLNGAWRSVVLDSLLPFSKRDKTPLFTTCHPAPHILPTSVGSPWAPLALKGYFKVHGGYSLRGSNPSSDIYEFMGWIPERIGLKEGFQREKEWKRMKEAWHKGNVMVSLGTGSKVSEGLVKLHAYGVIRLREEGHERILDIFDPGATSFTMSWDQVCAEFEALHLNWKPSVMPNTATRHWSWPKPPDLPSDADPGMMNTRYRLHVNASSPSSSLSEVWILLSQHITSRDRPLDDIALHVFEGLGPNNSRNLGAIYSEGLERTNPYTNSNHLLVRYQLRRPTSDLTLIPSRDRGIDQTGFTLNAFAPASISLSLERISRTLPFTQRISGNLTDRSAGGHPGWPTHMTNPQYKVVVRPGEGKSEISGRIILHGEKDVPWNVKLIWGRGQLVYELSEDLIVADTGSYSYGIAYCDIPELQPDTYTLIVSAFEPGQTGLFSLSLEATAPVSIIPIAAEGAGMYNRVVNGFWTERTAGGRPSGGTYESNPRVEMVLSKPATIQSRLYLPTRSPVPINLTIFKRAQGGALGEQLVTTGPYSDSICGVSTGKMKLDSGVYLLVPSSYEKSKGGWVLKIWSDVALSAEIVG
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.
What are the official names of this protein?
Calpain-like protease palB/RIM13, Cysteine protease RIM13.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
Protein: P15A_RABIT
Sequence: MAGVWKVLVVLVGLAVVACAIPRRRLRYEEVVAQALQFYNEGQQGQPLFRLLEATPPPSLNSKSRIPLNFRIKETVCIFTLDRQPGNCAFREGGEERICRGAFVRRRWVRALTLRCDRDQRRQPEFPRVTRPAGPTA
What is the function of this protein?
Binds to bacterial lipopolysaccharides (LPS), potentiates strongly the early antibacterial effects of BPI.  Inhibits the late lethal action of BPI.
What are the official names of this protein?
15 kDa protein A, P15R, Protein P15A.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RK21_PHATC
Sequence: MKYAIVEISGRQFWIETGKYYDFNRIPTELGKQITLNRVLLLNNEGEILIGKPYLDSVKIKGKILEHLRGKKTIVYKMRPKKKTRKKQGHRQELTRVLIEDIIIN
What is the function of this protein?
This protein binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L21, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LEPA_MANSM
Sequence: MKNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKNGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMNLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVAKIPAPKGDPNAPLQALIIDSWFDNYLGVVSLVRVKNGVLRKGDKIKVMSTGQTYNVDRLGIFTPKQVDKNELECGEVGWVVCAIKDILGAPVGDTLTSQHNPASSVLPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLNDASLFYEPETSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVELTNGDVIYVDSPSKLPPLNNISEIREPIAECNMLVPQEYLGNVITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYSFKRFQAADMVRVDIMINGERVDALALIVHKDNAPYRGRELVEKMKELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSRKKKLLQKQKEGKKRMKQLGNVEVPQEAFLAILHVGKDSK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: THIM_BACC7
Sequence: MNRKEISKVVDLVRESNPLVHNITNVVVTNFTANGLLALGASPVMAYAKEEVAEMASIAGALVLNMGTLRPEEVEAMLLAGKSANVNNVPVLFDPVGAGATSYRTEVARHIPAEIELAIIRGNAAEIANVINERWEIKGVDAGAGNGNVVSIAKQAADELNTVAVITGKEDVVTDGQRTIVIRNGHPILTKVTGTGCLLTSVIGAFVAVEKDYVKAAVAALTFYGVAAELAAAKTVEKGPGSFQIEFLNQLANTTSGDIEKYGEIEVI
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: DDL_VIBPA
Sequence: MIKNILLLCGGGSSEHEISLLSANFVEQQLNLIQNVKVTRVEIKNEGWVTDQGELVYLDLNTKQLCSNESNQTIDFIVPCIHGFPGETGDIQSLFEIAGIPYLGCGPEASSNSFNKITSKLWYDALDIPNTPYLFLTRNDEHAHRQAEQAFEKWGKVFVKAARQGSSVGCYSVAEKQAIAKAVNDAFGYSDQVLVEKAVKPRELEVAAYEMNGELHITKPGEVIAPDGAFYSYDEKYSSSSHSLTEVEAKNLTQEQIDKIRHASETVFKQMNLRHLSRIDFFLTEDNEIYLNEVNTFPGMTPISMFPKMLQNNGHKFHEFLEDCINSAK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPF_MICAN
Sequence: MKIPFTKYQGLGNDFILIDNRHSPEPLITAEMAVAMCDRHFGIGADGVIFALPGQAETDYTMRIFNSDGSEPEMCGNGIRCLAQFIARLEANNAIGRTYRIHTLAGTIIPRLEANEQVTVDMGPPQLLGSEIPTTLVKGSEKVLAVPLEVEGKDWLVTCVSMGNPHCVTFVGDLASIPLETIGPKFEHHPVFPQRTNVEFVEVIAPDYMKMRVWERGAGITLACGTGACAVVVAALLTGKCDRRCTVELPGGCLQIHWSQTDNRVYMTGPAKAVFEGIYPI
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_RICPU
Sequence: MPELPEVETLKNSLKDKLIGLIIENVELKRDNLRYKLSPLLATEILNTNILDVRRRAKYLIIDFNNDYSLIVHLGMNGRFTLQSANYKTQKHDHVIFDLSNGEKLIFNDTRRFGMIYSFKTDLLEKEFFNDLGIEPFSDLLTLEYLKDKLQTKKIPIKNLIMDNRVIVGVGNIYASESLHLARIHPDKSGNDLRDDEIENLIKAIRDVLTKAITAGGTTLKDFVNGDNKPGYFTKQLKVYGREGQSCLSCSSTIIKIKHSGRSTFYCKTCQYS
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: AP3BA_ARATH
Sequence: MAGIRLHVIAPLALAAVSKCARDPAVYVRRCAANALPKLHDLRLEEHASAIEELVGILLNDHSPGVVGAAAAAFTSICPNNFKLIGKNYKKLCQILPDVEEWGQILLIGTLLRYVVARHGLVRESLMLSIHGTNSNGFCEKDGLGRDLTLDKEDGGKSDSFDVNLVSLVSKCYIQGPDEYLSRSSCTDTVSSAFDTKETTSIAHNEDVKILLQCTSPLLWSNNSAVVLAAAGVQWIMAPLEDVKKIVKPLLFLLRSSSASKYVVLCNILVFAKAVPSLFAPHFENFFICSSDAYQVKAYKLEMLSLIATTSSIASILREFEDYIKDPDRRFAADTVAAIGLCAKRLMTIPTTCLDGLLALVRQESFAGDFESADGEAGVLVQAVMSIQTMIERDPLRHEKVLIQLFRSLDSIKVAAARATIIWMVGVYCSLGHIIPRMLTTITKYLAWSFKSEASETKLQILNTIAKVLISAEAGDFHMLKRIVVYVFELGEYDLSYDIRDRTRFLKKLLSCKLASHEPAEDSVASQENIAAHVVEHVFGRKLKSVSPITLHNRFYLPGSLSQIVLHAAPGYEPLPKPCSFVYEEQDQLSDLDKQREAAADLDGSEESSETGDENGSSDYDSESSNGSDFSSEGDERTVSNDANDPAAPLIQISETSVSADQEELRSRRALDLWLDDQPSTSNQTPSALNSNQSSYAKISIGDVGSRVKPKSYSLVDPGNGSGLKVDYAFLSEVSNVSPLHVCVEVLFENSSAEPILEVNLEDEESMKVADSSEQTLVGKANASYNNIPTLIPMEEISCLEPHQSTKRLIQVRFHHHLLPMRLTLHYNEKKVPVKLRPDLGYLVKPFSMSIEEFLATESRLPGMFEYSRRCTFDDHVKDSRTENGKDKFLSICESITLKVLSNSNLHLVSVDLPVANSLEDATGLRLRFSSKILSSEIPLLITITVEGKCTEVLNLTVKINCEETVFGLNLLNRIANFMVEPSSSAT
What is the function of this protein?
Part of the AP-3 complex, an adaptor-related complex which seems to be clathrin-associated.  The complex is associated with the Golgi region as well as more peripheral structures.  It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole.  It also function in maintaining the identity of lytic vacuoles and in regulating the transition between storage and lytic vacuoles.
What are the official names of this protein?
AP3-complex subunit beta-A, Adaptor protein complex AP-3 subunit beta-A, Adaptor-related protein complex 3 subunit beta-A, Beta-3B-adaptin, Clathrin assembly protein complex 3 beta-A large chain, Protein-affected trafficking 2.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Protein: PYRH_BACTN
Sequence: MAKYKRILLKLSGESLMGEKQYGIDEKRLAEYAAQIKEIHEQGVQIGIVIGGGNIFRGLSGANKGFDRVKGDQMGMLATVINSLALSSALVAAGVKARVLTAVRMEPIGEFYSKWKAIECMENGEIVIMSGGTGNPFFTTDTGSSLRGIEIEADVMLKGTRVDGIYTADPEKDPTATKFSDITYDEVLKRGLKVMDLTATCMCKENNLPIVVFDMDTVGNLKKVISGEEIGTVVHN
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_MYCMM
Sequence: MKVHKGDTVLVVSGKDKGAKGKVLQAYPERNRVLVEGVNRIKKHTAISTNQRGAKSGGIVTQEAPIHVSNVMVVDSDGKPTRIGYRVDEETGKRVRISKRNGKDIQA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: IF1_RUEST
Sequence: MAKEDTLEFPGVVKELLPNATFRVELENGHEIIAHTAGKMRKNRIRVLAGDRVQVEMTPYDLTKGRINYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_SULNB
Sequence: MLTFSDMLLKLQQFWAEQGCNIVQPYDIPAGAGTFHPATLLRSLDSKPWAAAYVAPSRRPTDGRYGENPNRLGAYYQFQALIKPSPDNIQELYLKSLEYLGLNLKEHDIRFVEDNWESPTLGAWGLGWEVWLDGMEVTQFTYFQQVGGIACDPVAVEITYGTERLAMYLQGVESVFDIVWNRNGDEVTTYADVHKESEYEFSKYHFEVATVEKLFQHFEDASNECKLCLEVGLPLPAYDQCMIASHAFNVLDARKAISQAQRQNYILKVRELSIGCAQLYKAQEEERNQRVRGT
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_THEPX
Sequence: MNILIDNRQDKVDAINLEELVEKVIKTVLEVEEVIDNVEVSVSFVDNEEIRKLNKYYRGIDKPTDVLSFPLAEFEDTYGEVEEIEEDSEEVQPIGDIVISLEKALEQSMEYGHSFEREVAYLTAHSMLHLLGYDHETEEERKIMREKEEEVMARLNIGR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_BUCTS
Sequence: GRTSIDNLCRIVESAIKAGATTINIPDTVGYTIPSQFKTIIKNLFNKVPNINNAIISAHCHDDLGLAVGNAIASIEAGVRQIEGTISGIGERAGNTALEEVILTIKLKEELLNVFTNIKHNELYRTSQLISQLCNTPIPANKSIIGSNAFAHSSGIHQDGILKNRANYEIIDPKTIGVKAVQLNLTSRSGRAAVKHHMHEMGYQDDDYDLNQLYVNFLKLADKKGQVFDYDLEALAFISNQEDKDQEHFQLKYFSIHSGSTGVSTASVKLLCGNKILNEIITTRNGPINSIYQALNNIAGLPIVLEKFHLVGKGEGRDALGQVDIVVKYNNRKFHGIGLATDIIESSIKAMLNVLNNIWLSNKIKSKIKNIKNKK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: FTSH_SYNC1
Sequence: MTRSLLWQMVIVLGAILMVNYVLTTLTPQTQEPVVDVSYSRFKTELAADNVAAITFEGNNVVGNLRERTILNRVEGTEEVQSFLRFRTTMPPVTDTRLLDDLEQRKVDVKVRPESKPSPWATAMIYMLPWLLIVGVWWFVIKGMRTRQGPGGGMMGGFSKSGAKMYTKERSRVTFADVAGLDEAKQELMEIIEFLRNPKKFMRLGAKAPRGVLLVGPPGTGKTLMARAVAGEAEVPFFTISASQFIEMFVGVGASRVRDLFNNAKKNAPSIIFIDELDAVGRSRGTGLGGGNDEREQTLNQLLSEMDGFEAHDEVIVMSATNRPDVLDPALLRPGRFDRQVTVERPDWRAREEILKVHTRQVPIDEDVDLQIIARSTPGMCGADLENLVNEAALIAARENAQKVTMQHFEQAKDRVLMGTERKLVMSQQEKRITAYHEAGHTLLARLSPGADPIHKVSIIPRGQALGVTQQLPVDDRYHYSRSYLMTRIAVSLGGRAAEKAIFEEYSTGAQNDLKQATDLAEKMVCQWGMSERVGPMSINRGEEHPFLGRKLASDNAFSQHMAWIIDQEIEKVVKAGEQAADEIIANHLPVLKKLADALLEEEVLDRTRVDEVLRETGIEVQDDPAAHPDGDHVLQGELAGGAVEG
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: PUR7_STRP1
Sequence: MTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVVTHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGHVLETPIVEFYYKNDDLDDPFINDEHVKFLGIVNDEEIAYLKGETRRINELLKGWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEKLIAL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: QUEC_SULNB
Sequence: MGKKAVCIISGGMDSALSAKIAQEEGYEIIALHFNYGQRTRNKELECFRKITQELNASESYEIDLDFFEQIGASALTDKSIDVPIGGLEEGVPVTYVPFRNGIFLSIAAAIAEKHGAEALFIGVVEEDSSGYPDCRESYIEQMQKAINLGTKDETNIEIKMPLVSLRKSQIVQKAIELGVPLEDTWSCYQAEDAACGVCDSCRLRLRGFEVAGVKDPIAYRK
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: PAGP_SODGM
Sequence: MRLFYQRISLLISLCGFFSAAWASDVQPASSTGLWQRFTQNVAETWHHSPHQDLYVPAITWHNRFTYDDEHIRRYNERPWGAGYGISRYDEKGNWHAIYLIAFKDSFNKWEPFGGYAWEKQWRPFDRYQDIHFGAGFTAGVTARDNWKYIPVPALLPLASVGYKQLTFQATYIPGTYNNGNVFFAWLRYRF
What is the function of this protein?
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.
What are the official names of this protein?
Lipid A acyltransferase PagP, Lipid A acylation protein.
What is the protein family that this protein belongs to?
Belongs to the lipid A palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: VMP1_PONAB
Sequence: MAENGKNCDQRRVAMNKEQHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLLAVLIATYYVEGAHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEGGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQDFASRAKLAVQKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPFQEYLEAQRQKLHHKSEMGTPQGENWLSWMFEKLVVVMVCYFILSIINSMAQSYAKRIQQRLNSEEKTK
What is the function of this protein?
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes.  Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine.  Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly.  Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation.  In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required.  Modulates ER contacts with lipid droplets, mitochondria and endosomes.  Plays an essential role in formation of cell junctions (By similarity).  Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death.  Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity).
What are the official names of this protein?
Vacuole membrane protein 1.
What is the protein family that this protein belongs to?
Belongs to the VMP1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi- pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GAG_HV1B5
Sequence: MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSSQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNSTTIMMQRGNFRNQRKIVKCFNCGKEGHIARNCKAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSYKGRPGNFLQSRPEPTAPPFLQSRPEPTAPPEESFRSGVETTTPPQKQEPIDKELYPLTSLRSLFGNDPSSQ
What is the function of this protein?
Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.