PharMolix/UniProtQA huggingface dataset:
Protein: GMHA_SHESA
Sequence: MLERIKDSFTESIQTKIDAAEALPESIAKAAEMMVQCLLGGNKILACGNGGSAGDAQHFSAELLNRYEIERPPLPAIALSTDTSTITAIANDYSYDEIFSKQILALGQPGDILLAISTSGNSGNVIKAMEAALSRDMTIVALTGKDGGAMAGLLSVGDVEIRVPSNVTARIQEVHLLVIHCLCDNIDRTLFPQDEQQ
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURQ_LIGS1
Sequence: MKIAVIVFPGSNCDIDLYEALHTVCDADVEYVSYKQDNLDGFDAVMLPGGFSYGDYLRCGAIARFSPIMPAVIEFAKNGKPVFGTCNGFQILTEVGLLPGALKQNNSLKFVCKTVELTVENTNTPFTSLYKKGEKINLPIAHADGSYYADEELLAELEENGQVVFRYSKENPNGSLNDIAGITNKQGNVLGMMPHPERAVEMLLGNEDGLRVFKSLLEEGKVKG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_XANOM
Sequence: MHCPFCQHSDTRVIDSRVSEDGTTIRRRRECEACGERFSTLETIELKLPTVVKSDGGREAFDARKLRTSFDRALQKRPVAEEQIEAAVRSVVHQLRMSGEREVGSLRVGEYVMVELRKLDHVGYVRFASVYRSFQDVADFREEIEKLERELPVGSEQLPLLEVALERAGKPGKR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: WTF14_SCHKA
Sequence: MENNHHLAKDSLDELNPKRGKGEHETQVSQYTVVEEATIPQSLVKTSRSADHKVMEASKVADTRTAWSTKIPAVLLPVFVINIALFKYLVFANFSTKDRVLFGLGNGGINIFSMWLLLATYETWFRSIKEVIVACGAGIRSFPQKRGVNMLYAILKLTFVNAFAIPLLMFFRSHFEQWRLGCPLVERVIGVMLNVAYFIIEIENPGLFTRVFNKYCDCLFAIRDILNRN
What is the function of this protein?
May act in meiotic drive.
What are the official names of this protein?
Wtf element wtf14.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to the endoplasmic reticulum in both vegetative cells and in spores.
Protein: BCL9L_HUMAN
Sequence: MRILANKTRLPHPRRREAPGSPPLSPRGHCPPAPAKPMHPENKLTNHGKTGNGGAQSQHQNVNQGPTCNVGSKGVGAGNHGAKANQISPSNSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLERKQPYSGDEWCSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAPHGPPPGLRPDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQNVPRAKLDQAPKVPPTPEPLPLSTPSAGTPQSQPPPLPPPPPPAPGSAPPALPPEGPPEDSSQDLAPNSVGAASTGGGTGGTHPNTPTATTANNPLPPGGDPSSAPGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQTQSLGGPPLEHEVPGHPPGGDMGQQMNMMIQRLGQDSLTPEQVAWRKLQEEYYEEKRRKEEQIGLHGSRPLQDMMGMGGMMVRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQLRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEVPMNAMQRPVRPGMGWTEDLPPMGGPSNFAQNTMPYPGGQGEAERFMTPRVREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEMERMMQAHRQMDPAMFPGQMAGGEGLAGTPMGMEFGGGRGLLSPPMGQSGLREVDPPMGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDLMGPQGLSPEEMARVRAQNSSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQDMGNTQDMFSPDQSSMPMSNVGTTRLSHMPLPPASNPPGTVHSAPNRGLGRRPSDLTISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSANPPGPLKSPQVLGSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSSSSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPPAMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMPFPPRLQQPHGAMAPTGGGGGGPGLQQHYPSGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMGDAYPPGVLPGVASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSENQPPKAQPPNLHLMNLQNMMAEQTPSRPPNLPGQQGVQRGLNMSMCHPGQMSLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLMKQRGVGGEVYSQPPHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMGYLPAPGGMANLPF
What is the function of this protein?
Transcriptional regulator that acts as an activator.  Promotes beta-catenin transcriptional activity.  Plays a role in tumorigenesis.  Enhances the neoplastic transforming activity of CTNNB1 (By similarity).
What are the official names of this protein?
B-cell CLL/lymphoma 9-like protein, B-cell lymphoma 9-like protein, BCL9-like protein, Protein BCL9-2.
What is the protein family that this protein belongs to?
Belongs to the BCL9 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTPH3_MDBVW
Sequence: MPGYCFEIFNVFDFFDKTNKANFWEFVRLEHAQVMDIPISGTVNHFLKPENLRKNRYHDVTCWDNSRVVLSSHGSKMYDYGDSDGKKIIVTSQDSDSTYIHASFVNGFKEANKFICCQGPKESTSGDFWKMVSEHNSSVIVSLTETDDEDQVCYEYWVKEEDYELAFGRYVVKTLEIIEESSFTRTRLRLTDVSSDTSREIHHFWYPHWSDYGNPTNPAEILNLISKVNQKRKEMKKTADSQPGPIVVHCSAGIGRTGTFCTIDNALSQLRKEQTVCLPQTVLKIRKQRHSSVFLPEQYAFCYKAVRYALIREIKKKFFY
What is the function of this protein?
Suppresses host immune cell adhesion and phagocytosis.
What are the official names of this protein?
Tyrosine phosphatase H3, PTP-H3.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: EFTS_SALTO
Sequence: MSNFTAADVKKLRDLTGAGMMDSKKALTEAEGDFDKAVEVLRVKGAKDVGKRAGRTAANGLVAHSGKALLELNCETDFVAKTDSFVALAQQLVEHGERTGVNSAEELLASEIDGKGVAELIQEQSAKIGEKLVLNRFAKLDGTVAVYLHRKAQDLPPAVGVLVQYTGRTDEAGDADARGVAMQIAAMRPQYLSRDEVPAEVVESERRIAEQTAREENKPEAALPKIVEGRVNSFFKDFVLLEQASVTDNKKPVRQVLAEAGVEVTRFVRFEVGQA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF6_HUMAN
Sequence: MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP
What is the function of this protein?
Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700).  Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621).  Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956).  In contrast, down-regulates transcription of MDM2 (PubMed:11583621).  Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117).  Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956).  Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 6, RNA polymerase II TBP-associated factor subunit E, Transcription initiation factor TFIID 70 kDa subunit, TAF(II)70, TAFII-70, TAFII70, Transcription initiation factor TFIID 80 kDa subunit, TAF(II)80, TAFII-80, TAFII80.
What is the protein family that this protein belongs to?
Belongs to the TAF6 family.
What are the subcellular locations of this protein?
Nucleus. SUBCELLULAR LOCATION: [Isoform 4]: Nucleus.
Protein: YA065_YEAST
Sequence: MNSATSETTTNTGAAETTTSTGAAETKTVVTSSISRFNHAETQTASATDVIGHSSSVVSVSETGNTKSLITSGLSTMSQQPRSTPASSIIGSSTASLEISTYVGIANGLLTNNGISVFISTVLLAIVW
What are the official names of this protein?
Uncharacterized protein YAL065C.
What is the protein family that this protein belongs to?
Belongs to the flocculin family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL34_LEPBL
Sequence: MKRNYQPSRVKRARTHGFRARMATAGGRKVLSRRRKKGRYKLTVSNEKLGKKY
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: CHS4_SORBI
Sequence: MAAATVTVEEVRKAQRATGPATVLAIGTATPANCVHQADYPDYYFRITKSEHMTELKEKFKRMCDKSQIRKRYMHLTEEYLAENPNMCAYMAPSLDARQDIVVVEVPKLGKAAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKMLGLRPSVKRLMMYQQGCFAGGTVLRVAKDLAENNRGARVLVVCSEITAVTFRGPSESHLDSMVGQALFGDGAAAVIVGADPDERVERPLFQLVSASQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIERSLEEAFKPLGITDYNSIFWVAHPGGPAILDQVEAKVGLKKERMRATRHVLSEYGNMSSACVLFILDEMRKRSAEDGQATTGEGLDWGVLFGFGPGLTVETVVLHSVPITTGAAITA
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 4, Naringenin-chalcone synthase 4.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: ALR_SHEON
Sequence: MKPFPRAEISSSALQNNLAVLRQQASSSQVMAVVKANGYGHGLLNVAKCLNNADGFGLARLEEALELRAGSVKARLLLLEGFFRSTDLPLLVEHDIDTVVHHESQIEMLEQATLSKPVTVWLKVDSGMHRLGVTPEQFSAVYARLTACKNVAKPIHLMTHFACADEPDNHYTQVQMQTFNQLTADLPGFRTLANSAGALYWPKSQGDWIRPGIAMYGVSPVTGDCGANHGLIPAMNLVSRLIAVREHKANQPVGYGCYWTAKQDTRLGVVAIGYGDGYPRNAPEGTPVWINGRRVPIVGRVSMDMLTVDLGHDATDQVGDDVLLWGQALPVEEVAEHIGTIAYELVTKLTPRVAVCLA
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: IF2_GLUOX
Sequence: MSDGNERNQDGNNTPSQGGEQTRSSRLSLRPAGRQEVGRTVDAGSVRQSFSHGRSKVVQVEVRKPKRNAAGPGAGAAARGGRAGGRALTAAELAARQRALELQRKAAAEEAARREEEKIQIMSAAEAARRAAEEERLISEQKAAEIAALKESEQQAAREQAAAEAAARAAEQAAAEAAAREAEEAARSAPLDPRSHSTGGVQLAAPVQRLRPLAERAIMPPRPVQPSRPAAAAPARNNETLHLRSGAAAGGDDERRPAPRRSGPGAPPAPPRRPSAPSRKGGGSDRRSGRIDVRAAIEGDDDKTRSLASVRRQRDRERRQAELERLRSDQVRVVRDVIVPETITVAELANRMAARQGEVIKALMKMGVMATAAQSIDGDTAELVVEEFGHRIKRVSESDVEIGIEGVEDNADDLKPRAPVVTVMGHVDHGKTSLLDALRTTDVAASEAGGITQHIGAYQITAPSGKKITFIDTPGHEAFTSMRARGASVTDIVVLVVAADDGVMPQTIEAIKHAKAANAPIIVAINKIDKPGANPNRVRQELLNHEIVVEEMGGDTQDVEVSALKRIGLDKLEECILLQSEMLDLKANPDRVAEGVVIESRLDRGRGPVAALLVQKGTLRRGDIVVAGAEWGRVRAVLDDRGRQVKEAGPSMPVEVLGLTGVPGAGEPFVVVENDARAREISEFRQRKIKEKEAASQVAARGTLDQMLARIQAGVQKEVALLIKADVQGSAEAISTTVQKLAHEEVAVRVLNASVGQITESDIQLAKASDAIIVAFNVRATTQARELAQREGVDIRYYSIIYQVADDVEQLVKGKVAPKHREKFLGYAEVRQVFNITKTGKVAGCYVTEGLVKRGCGVRLLRDNVVIHEGELSQLKRFKDDVKEVARGYECGLSFAGYNDLREGDMVECYEMEVIPA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_METM7
Sequence: MPTINVNKVDLERLSNISLSDKMIEDRFPMMGVEVEEIFEEVDKSGKKQKMVQFSINPDRPDYLSVEGLARGFRGFMGITTGIQEFEVLPSDIKVTVEENKTRPYVAFALVKNVLMDELVLESMINLQEKLHWAIGRDRKKLAIGIHDFDKVKAPFTYKEIKGDEIKFVPLGYEDEEMTPREIIEKHEKGIKYAHLIQDDRFPIIVDVNGEVLSLPPIINGTLTKVTPTSKNLLIDITGTEKEAVEETLNIIVCALAERRGTIVSVNVNGKKYPDLTLKSRIISIESINKKLGLELNPGEIIQAVKKSGMDALYEDGNLIVKIPAYRNDILHNVDLKEEIAINYGYEKFEGKLPSVATTGSKDPVEKKCNAMSDLMIGLGFYEVMNLTLSNQDTLFEKMNLKVEEKDYIEVLKPASIEHRVLRTSILPLLLETLYINKHHSLPQKIFEIGDCVIIDENDTETDTKCKNIKKIAGAITHPLTNFNEIKSSTEALLREFFEDFEFENYEHPAFIPGRCAKIIKDGKEVGFFGEIHPEVILNFELEHPIVGFEITIE
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDJC_VIBVU
Sequence: MKVIFNADDFGLTRGVNDGIVHAHLDGVVRSTTMMVGMPAEAHAVELANHLPELKVGLHLRFTAGRPLTEEQNLVGRDGDFTPYGQFWHRRDYDPIAIHNEAVAQVEYFLALGLNLSHIDSHHHAHTHPQFEPVIYDIARTYQVPLRSTGLAGEEEFGCRYHFTDHFYDKRVGHDSLIQHLLTLKEHYDVVEVMCHPAIVDTALEACSGYAKQRELELAILTSDELKLSLRKHDIEVTDYSELIFAPLHSCV
What is the function of this protein?
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
What are the official names of this protein?
Carbohydrate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family.
Protein: HIS3_CHESB
Sequence: MQASELRFAPPSADKSALEEGRLFTPRFDANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGNLQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRNVKVEDGRPILTENG
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL332_STAA1
Sequence: MRVNVTLACTECGDRNYITTKNKRNNPERVEMKKFCSRENKQTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: SYGA_PSET1
Sequence: MQKYDVKTFQGLILALQDYWAQQGCVIIQPLDMEVGAGTFHPQTFLKSIGPEPMSSAYVQPCRRPTDGRYGENPNRLQHYYQFQVVLKPSPDNIQELYLGSLAAVGIDTLTDEVRFVEDNWESPTLGAWGLGWEIWLNGMEVTQFTYFQQVGGIECSPVTGEITYGLERLAMYIQGVDSIYDLVWADGPLGRVTYGDVFHQNEVEQSTYNFEHANVEDLFAQFDKCEAESQKLIEANLPLPAYEQVMKASHAFNLLDARHAISVTERQRYILRVRALSKACAQSYYDKREALGFPLCKDK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAFA_CANLF
Sequence: MLPPKLHALFCLCSCLTLVHPIDWQDLNPVAHIRSSAWANKIQALMAAASIRQSRIPKGNGSYSVGCTDLMFDYTNKGTFLRLYYPSQEDDHSDTLWIPNKEYFFGLSKYLGTPWLMGKILSFFFGSVTTPANWNSPLRTGEKYPLIVFSHGLGAFRTIYSAIGIDLASHGFIVAAIEHRDGSASATYYFKDQSAAEIGNKSWSYLQELKPGDEEIHVRNEQVQKRAKECSQALNLILDIDHGRPIKNVLDLEFDVEQLKDSIDRDKIAVIGHSFGGATVLQALSEDQRFRCGIALDAWMLPLDDAIYSRIPQPLFFINSERFQFPENIKKMKKCYSPDKERKMITIRGSVHQNFADFTFTTGKIVGYIFTLKGDIDSNVAIDLCNKASLAFLQKHLGLRKDFDQWDSLIEGKDENLMPGTNINITNEHDTLQNSPEAEKSNLD
What is the function of this protein?
Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (By similarity).  At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (By similarity).  Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position.  Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (By similarity).  Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (By similarity).  Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (By similarity).  As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (By similarity).  Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (By similarity).
What are the official names of this protein?
Platelet-activating factor acetylhydrolase, PAF acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, LDL-associated phospholipase A2, LDL-PLA(2), PAF 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Note=Associates with both LDL and HDL particles in plasma. Mainly associates with pro-inflammatory electronegative LDL particles.
Protein: GPDA_ACIC5
Sequence: MSRIAVMGSGAWGTAIALHLARQSEHELLLWSHSARVAESIRAFGENRDFLPGYPVPPALAVTVTADAEAALEFAEIIISVMPSHHVRHSYEQIFAPYLTPSHRILSATKGLEDATYLRMSQVISDVLLRRGLDLPLAVLGGPSFAQEVAAGSPTAVTVASKDAAFAGELQQVFSNGTLRLYTNDDVCGVEMGGALKNIIAIASGVVTGLGLGHNSTAAIITRGIAEMTRLAVACGGRRETLAGLAGLGDLVLTCTGSLSRNRTVGVELGKGRGLDDILAGLGGKVAEGVRTTAAALGLAASLGVEMPIAQQVHTVLQGQASPLQAMQYLMSRPGRDE
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_VESOH
Sequence: MPSTWLAPAKINLFLHINKRRKDNYHNLQTIFQLLDYCDKLTCTITNNGVIKRTSGNKSVKQDQDLIIKAAKALQQYTGTTLGANLSIVKNIPIGGGLGGGSSDAATTLVALNQLWDTKLTQAQLMKLGLNLGADVPVFIFAQSAWAEGIGNILSPIKTPDHYFLVVFINKHISTKEIFSHYALTISEPQGKIANFSELVNTHNDCLQVAIKLEAEIGVALEHLNTCYNRVGQARMSGTGSCVFNEFLTEKDALAAAKKVPKKWMSFVTRAINNSPIYNWAVAKR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: C71BK_ARATH
Sequence: MAISFLCFCLITLASLIFFAKKIKHLKWNLPPSPPKFPVIGNLHQIGELPHRSLQHLAERYGPVMLLHFGFVPVTVVSSREAAEEVLRTHDLDCCSRPKLVGTRLLSRNFKDVCFTPYGNEWKARRKFALRELFCLKKVQSFRHIREEECNFLVKQLSESAVNRSPVDLSKSLFWLTASIFFRVALGQNFHESNFIDKEKIEELVFEAETALASFTCSDFFPVAGLGWLVDWFSGQHKRLNDVFYKLDALFQHVIDDHLNPGRSKEHEDIIDSMLDAIHKEGKDSSLELIIDHIKGFLANIFLAGIDTGALTMIWAMTELVKNPKLIKKVQGEIREQLGSNKARITEEDIDKVPYLKMVIKETFRLHPAAPLILPRETMAHIKVQGYDIPPKRRILVNVSAIGRDPKLWTNPEEFDPERFMDSSVDYRGQHYELLPFGSGRRICPGMPMGIAAVELGLLNLLYFFDWKLPDGMTHKDIDTEEAGTLTIVKKVPLQLVPVRVQ
What are the official names of this protein?
Cytochrome P450 71B20.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HPRT_METM7
Sequence: MSRLLEESLKTCPIVKRGEYHYFIHPISDGVPLVKPELLRDVSTRVIKMIDTDIDKIVTAEAMGIPIVTAVSIATDIPYVIMRKREYLLEGEIPVHQETGYSKGELYLNGINKGDKVVILDDVISTGGTLVAIINALKRAGADIKDVLCIIDRGNGQNVVEEKTGYKVKTLVKIEVVDGKVQILE
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
What are the official names of this protein?
Hypoxanthine/guanine phosphoribosyltransferase, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_CALS8
Sequence: MKASKIREMTNQELHNELKKLKNELFNLRFQLATNQLENPMRIREVKRTIARIKTILRERELEQEKANKNAK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: IRC6_YEAS6
Sequence: MVLQYPQNKILVLSDHPHNFSKTQFLQDLFHCSSTGISIVKDQTWENRYYKVHFDLYIDSCKDIPVWVEEFITPECEPLRNVMAGIILITDIRQTKPQELLHQFMIAAHRNTFVVLVNVNEEVEQDEIDELNEIWSNAFTNVIELVNWKRSKPTVNHNDYGEKLGLDRIQEIIDTHDWLNCEVLPATKIREEIPNEMPLEQIIRNLQSARLKYKSIENSSEADAFANEMADELSRYL
What is the function of this protein?
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
What are the official names of this protein?
Increased recombination centers protein 6.
What is the protein family that this protein belongs to?
Belongs to the IRC6 family.
Protein: GLMM_PARMW
Sequence: MVQRAVPSIGPSLGSSAPGFGTDGIRGRAGTELSPALCLQVGYWIGRVLKADGPVLIGMDSRSSGSMLVAALTAGLTAAGRDVWELGLCATPAVPLLIREVGAAGGLMVSASHNPPADNGIKVFGADGTKLSAERQARVETGLRGEVEDDGPSRCGRSVQRQDLLRSYQDKLLSSVGDRRLNGVPIVLDLCWGSATACAAEVFQTLGADLTVLHGQPDGERINVACGSTQLDPLRQAVVAQGAVMGFAFDGDADRMLAVDARGRVVDGDHVLYLWGSVLQDQKALPGDRLVATVMSNLGFERAWERRGGELERTPVGDQHVHAAMVANGAALGGEQSGHILAASHGLCGDGVLTALQLATLCHGQDIALSDWLDRSFKAYPQKLVNVTVPDRARRKGWSSCMPLQEAVLQAEASMGAAGRVLVRASGTEPVLRVMVESEDQSLVDRWTQHLAAMADEHLNAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RNPA_PELTS
Sequence: MKVLDVLKKNKDYGRVCRRGKSVADRHIVMYFLDNNLGRCRYGFAVSRKIRSAVRRNRARRLLREACRLNKEKFPEGYDFVFMARRDMTDLKCQQVEESILKLLKRAEINRS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: IHFB_AZOVD
Sequence: MTKSELIERIVTQQGQLSAKDVELAIKTMLEQMSQALATGDRIEIRGFGSFSLHYRAPRVGRNPKTGQTVRLDGKFVPHFKPGKELRDRVNE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RL4_STAAC
Sequence: MANYDVLKLDGTKSGSIELSDAVFGIEPNNSVLFEAINLQRASLRQGTHAVKNRSAVSGGGRKPWKQKGTGRARQGTIRAPQWRGGGIVFGPTPRSYAYKMPKKMRRLALRSALSFKAQENGLTVVDAFNFEAPKTKEFKNVLSTLEQPKKVLVVTENEDVNVELSARNIPGVQVTTAQGLNVLDITNADSLVITEAAAKKVEEVLG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.