PharMolix/UniProtQA huggingface dataset:
Protein: CDK14_DASNO
Sequence: MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKEDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKVRVQRTQSTFDPFEKPTNQVKRVHSENNACINFKTSSAGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPENVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
What is the function of this protein?
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin.  Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway.  Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3.  Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo.  May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 14, Cell division protein kinase 14.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.
Protein: UPPP_XYLFT
Sequence: MFELFTALMLGILEGITEFLPVSSTGHLLIAEHWLGSRSDFFNIVIQAGAILAITFVFRKKVWSLATGLDKYSNRDYVMKLATAFLITAVVGLAVRKANWQLPETIQPIAWALIIGGIWILIAESVAKHLPERENVTWSVAIAVGLAQVVAGVFPGTSRSASTIFLAMLLGLSKRSAAAEFSFLVGIPTMFSASSYACFELFKRGELLHENWLEVSVAFVAAMLTGFAVVKWLLGYIKNHSFAPFAYYRIALGLVLLTWLT
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILVD_SULTO
Sequence: MNPDKKKRSNLIYGGYEKAPNRAFLKAMGLTDDDIAKPIVGVAVAWNEAGPCNIHLLGLSNIVKEGVRSGGGTPRVFTAPVVIDGIAMGSEGMKYSLVSREIVANTVELVVNAHGYDGFVALAGCDKTPPGMMMAMARLNIPSIIMYGGTTLPGNFKGKPITIQDVYEAVGAYSKGKITAEDLRLMEDNAIPGPGTCGGLYTANTMGLMTEALGLALPGSASPPAVDSARVKYAYETGKALMNLIEIGLKPRDILTFEAFENAITVLMASGGSTNAVLHLLAIAYEAGVKLTLDDFDRISQRTPEIVNMKPGGEYAMYDLHRVGGAPLIMKKLLEADLLHGDVITVTGKTVKQNLEEYKLPNVPHEHIVRPISNPFNPTGGIRILKGSLAPEGAVIKVSATKVRYHKGPARVFNSEEEAFKAVLEEKIQENDVVVIRYEGPKGGPGMREMLAVTSAIVGQGLGEKVALITDGRFSGATRGIMVGHVAPEAAVGGPIALLRDGDTIIIDANNGRLDVDLPQEELKKRADEWTPPPPKYKSGLLAQYARLVSSSSLGAVLLT
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ASNA_PLACH
Sequence: MSKAGSDASSISCSLSLDSDSCDDEFYETNLNKLIENTSLNWIFVGGKGGVGKTTTSCSIAIQLAKKRESVLLLSTDPAHNTSDAFNQKFTNKPTLINSFDNLYCMEIDTTFSEDTAFKINKSDFLNSIIPELLQSFPGIDEALCFAELMQSIRNMKYSVIVFDTAPTGHTLRLLAFPDLLKKALGYLINLKEKLKGTLNMLQSLTSNEMEFEGMYDKINHLNTMSISIQENFQNPLKTTFVCVCIPEFLSVYETERLIQELTKKNISCYNIVVNQVVFPLTSQDANIESCEGLLKQIKDTNIKDSFSSLILKAKELEDVYISRRKLQSKYLTQIKNLYGNYFHIVCMPQLKSEIRGLDKIASFSEMLLQSKDIPIYSPQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: Y1295_PASMU
Sequence: MLFHIYHLSRFTTANKISGNYAAFCASLTKAETRSDKDAPFSTQALTRSKSKRKRSALPVANGLKKPTRSIKRPSRGERLSATTI
What are the official names of this protein?
Uncharacterized protein PM1295.
Protein: CCA_PSEPG
Sequence: MHIYKVGGAVRDRLLGRPVSDIDWLVVGATVEEMLAKGYRPVGADFPVFLHPKTGEEYALARTERKSGRGYGGFTFHASPDVTLEEDLIRRDLTINAMAEDEAGTVYDPYHGKDDLDQRLLRHVSPAFAEDPLRVLRVARFAARYAPLGFRVADETLELMRQISASGELQALTAERSWKEIERALMEARPQVFFQVLGACGALHELLPELVDDTQALAALEQAAAHEQPLHVRWACLLRGLAPAPIKTVNQRLKAPRECQELALLTGECLAQGNQAQELPATALLELLQKFDVYRRPQRFEDFIVVCEMAALGDGKSSYPQADYLRGAAAAARAVDVKPLVQAGLTGQALGEALKRERLKAVEAYKRS
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 2 subfamily.
Protein: GUN2_RUMJO
Sequence: MIKGSSLKRIKSLVMMAIFSVSIITTAIVSSAADQIPFPYNATYPYGAYSCLADSQSSANNLLKSEWEQWKSAHITSNGARGYKRVQRDASTNYDTVSEGLGYGMLLAVYFGEQQLFDDLYRYVKVFLNSNGLMSWRIDANGNIMGQNAIGAATDADEDIAVSLVFAHKKWGTSGGFNYQTEAKNYINNIYNKMVEPGTYVLKPGDMWGGSDVTNPSYFAPAWYRIFADFTGNSGWINVANKCYEIADKARNSNTGLVPDWCTANGTPASGQGYDFYYDAIRYQWRTAIDYSWYGTAKAKTHCDAISNFFKNIGYPNIKDGYTLSGSQISANHTATFVSCAAAAAMTGTDATYAKNIYNECVKVKDTGNYTYFGNTLRMMILLYTTGNFPNLYSYSSQPQQGLKGDVNNDGAIDALDIAALKKAILTQSTSNINLTNADMNNDGNIDAIDFAQLKVKLLN
What are the official names of this protein?
Endoglucanase 2, Cellulase 2, Endo-1,4-beta-glucanase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 8 (cellulase D) family.
Protein: ATPD_FUSNN
Sequence: MIKSQVGRRYSKAIFEIAEEKKQVKEIYEMLNSAMVLYRTDKEFKHFILNPLIDNEQKKSVLNEIFGKDNSENLNILLYILDKGRMNCIKYIVAEYLKIYYRKNRILDVKATFTKELTDEQKKKLIDKLSQKTGKEINLEIKIDKDILGGGIIKIGDKIIDGSIRRELDNWRKS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DER_BIFLO
Sequence: MDEGDEDLISGRGFTEGARKAGPKPVGVLAVVGRPNVGKSSLVNRILGRRAAVVEDTPGVTRDRVSYDAEWAGTDFKLVDTGGWEADVEGIESAIASQAQVAVTLADAVVFVVDGQVGMTTTDERIVKMLRAAGKPVVLAVNKIDDQASEYLAAEFWKLGLGEPYSISAMHGRGVGDLLDVALDKLKQAEKTSGYLTPSGLRRVALVGRPNVGKSSLLNQLAREERAVVNDLAGTTRDPVDEIVNIDGEDWLFIDTAGIKRRQHKLTGAEYYSSLRTQAAIERCELALILFDASQPVSDQDLKVMSTAVDAGRAIVLVFNKWDAMDEFDKQRLERLWNTEFDRVMWAERVNLSAKTGWHTNRLTRAMDKALESWDQRIPTGKLNAFLGKIQAAHPHPLRGGKQPRILFATQASTRPPRFVIFATGFLEHGYRRYIERSLREEFGFEGTPIQISVNIREKKKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: METXA_METMS
Sequence: MTERSVGYVETKHHHLKEPFRLVSGDELAEVSIAYETYGKLNSDKSNVILICHALTGDAHAAGWHEGDKKPGWWDIVIGPGKAFDTNKYFIICSNVLGGCKGTTGPSSTNPQSGLPYGLSFPRITIEDMVNLQHTLLNNLGISRLYAIAGGSMGGMQVLQWAVSYPGFMKRSIVLASTAISSPQQIAFNEVARQAIIRDPYWNDGDYYGVELPKQGLSLARMIGHITYLSDDSMHDKFGRDIRENEMFQVESYLHHQGDTFTSRFDPNSYLYLTGAIDKFDLSNGYSLAKTFSNIESEFMVISVSSDWLYPSYQSEEIVQALGSNDVDVQYRKLISHFGHDAFLLEKGQLNYLLSTFLGHLTVGDVMSEDVSTLHEGCTLEEAAQLMILKNATHIPILATSGRITGIVTSWDITRAVANKISSIENILSRDILTSRPDESLSSAALVMEDHAISALPVVDDRGCLVGILSSDTISAMVGKGTK
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_CHLPD
Sequence: MNTSNQHKAGHVTTRKLLDMKQQGEKISVLTAYDYTMARILDRAGIDVILVGDSASNVFSGHATTLPITIEEMIYHAKAVVRGVHDESGRAMVVVDMPFMSYQISGDEALRNAGKIMKEHGCDALKLEGGKIIADTVKRITDVGIPVMGHLGLMPQSIYKYGSYKVRAQEEQEAEQLLQDARLLEEAGAFAVVLEKIPSALAAEVTLMLTIPTIGIGAGSHCDGQVLVVNDILGLNREFHPRFVRQYANLNNVIDRAVQQYVDDVKQGGFPADDESY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFSA_ASPFU
Sequence: MWTTTSGLSGRSLRLSITFAAVVGFSLFGYNQGMMAGLLNGDEFVNSFPILKMPDNPTAGEKHYIDVIRGAVTSCYELGCFFGALFSMFCGNRLGRTRLIFMGASILIVGALLTTVCYTGKWEVGQFVIGRVVSGIGNGMNTATIPVWQSECSGAHNRGFLVCFEGAMIAGGTFIAYWVVFGISHAADSVQWRFPVALQIFFALVVATGALMLPDSPSWFVSRGLDNEACEVLGKIKGTSPDSDQVLHDFNLIKTDMESTKSEQSNWKTVFTFGKTQEFQRLLIGCSGQFFQQFTGCNAAIYYSTLLFQENLHMEKYLSLIMGGVFASVYALATIPSFFMIERVGRRKLYLIGFLGQGLSFVITFACLIKETEENSKGAAVGIFLFITFFAFTLLPLPWIYPPEINPLRTRTVGASASTCTNWMCNFAVVMFTPLFAGQSPWGVYLFFALFNFVGLIFGYFFYVETAGRELEEVDIIYAKAHVEGKMPFRVAHDLPKLSFEEIVQQSRELGLDTNDHVMLEKKELGLSSDSAQETEEVYEKQ
What is the function of this protein?
Major facilitator superfamily transporter that may be involved in A. fumigatus adaptation to azoles such as vorizonazole.
What are the official names of this protein?
Major facilitator superfamily transporter mfsA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SDHD_BURPS
Sequence: MPVGRSLSLDPNLLAQLQSHSPTLWLNPHQGMPLPDFAPTAADLADADARLRRCAGLLAELFAELRPSGGLIASPLQPAEPLKRAARAGHAQAGAWYVKRDDALPVAGSIKARGGFHEVLALAESIAERHGLAGADTDRRALASGAARARFARHTVMVGSTGNLGLSIGMLASALGFRTVVHMSADAKAWKKARLRTRGVEVVEHAGDYAKAVDAGRRQAAGMPCCHFVDDEGSRMLFLGYATAAAELAAQLAQAGRPVDARHPLFVHLPCGVGGAPGGIVYGLKALYGEHVHAFVAEPTASPCVLVQLAGDAAHPRSVYDIGLDNRTEADGLAVAQASPLAAALLRAQAAGAFTVDDRQLFAHLLDARERLGIDLEPSAAAAFGGPAWIAGSDAGRAYLRGRGIDPDAATHVIWATGGSLVPAQEHRRFQAHARAQRQVGGAGA
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: RL33_RHIME
Sequence: MAKATTIKIKLLSTADTGYFYVTTKNSRTMTDKMTKTKYDPVAKKHVEFKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: Y2896_ACIET
Sequence: MPADTAPMNLTHHFLIAMPGVEDASFSRSVVYLCEHSERGALGLIINKPTPISLEGLFEKVDLSLGREDLTLQPVFQGGPVQTERGFVLHEAMRGPQESEDESPYASTMTIPGGLEMTTSKDVLEALAHGAGPRRVLVTLGYSAWGEGQLESELAENSWLTVGADVSVIFETPVQERYDRALGLLGLQSWMLSPEAGHA
What are the official names of this protein?
UPF0301 protein Dtpsy_2896.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: RIMM_LACAC
Sequence: MQYFDVARILTTHGLHGEVKVNVITDFPEDRFAEGMQLELKDDIDRVLTIKKSRPFKQFWLLQFDEITDIDEAEKLRGKILVISEKDRGELPDGVYYYKDIFDCGVIDNETGKRLGKITDIQSPGANDIWLVHEDNGKEYWIPNIADVVKKIDIADKKVYVELMEGLRDED
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_WOLSU
Sequence: MDIFHAIILGIVEGLTEFLPVSSTGHLILVSELLGIKQDDFHKTFEISIQLGSILAVLALFRERLFSGVDIWLKLAVAFIPTGALGFLLYKHVKALFAPSTVAYALILGGIVFLVLEWLHKDKEYKINSVESIGYKEALAIGFFQALAMIPGTSRSGSTIVGGLILGLNRKVAAEFSFLLALPTMFIATGYDLYKNSHTLSIENLSALGVGFVVAFIFAMIAVKGFLKFISRFNFVPFGIYRIILGIIFLFYLDLI
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CFMC_ASPFU
Sequence: MKFFSVSLALAACLSMAAAQGLDGLPDCAKSCATNSIPASCGLDVKCICTDSSFISGISCCVLQSCGPDQQQEDAHPFFPTAAVEFANRICKTAGVTNMPQSPSCANTTQSATGTASKSSTATSGSSTESNASQTAATATTSTTPPTSPTSPTSTTGSTTSSAASTTNTTTGAAVTQHKDIGLIALAGAALAAFGLLA
What is the function of this protein?
GPI-anchored cell wall protein involved in stabilizing the cell wall.  Not implicated in virulence, heme uptake, and biofilm formation.
What are the official names of this protein?
GPI-anchored hemophore cfmC, GPI anchored CFEM domain protein C.
What is the protein family that this protein belongs to?
Belongs to the RBT5 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell membrane; Lipid-anchor, GPI-anchor. Note=Found anchored in the cell membrane as well as a covalently-linked GPI-modified cell wall protein (GPI-CWP).
Protein: PG147_VARV
Sequence: MITLFLILCYFILIFNIIVPAISEKMRRERAAYVNYKRLNKNFICVDDRLFSYNFTTSGIKAKVAVDNKNVPIPCSEINEVNNNKDVDTLYCDKDRDDIPGFTRSCYRAYSDLFFTT
What is the function of this protein?
Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry.  Also plays a role in cell-cell fusion (syncytium formation).
What are the official names of this protein?
Virion membrane protein OPG147.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG147 family.
Protein: GSA_SYNWW
Sequence: MRTERSIELFARAREYIPGGVNSPVRAFKAVGNNPLFIKEGHGSKIYDVDGNEYIDYVCSWGPLILGHSHPQVVQAICEAAEKGSSFGAPCEQEIELAQLICEAIPSVEKVRMVNSGTEATMSAVRLARAFTGRNHIVKFEGCYHGHADHFLIQAGSGLLTAGVPTSPGVPEAFARHTLVARYNDLDSVERLFAQAPADIAAVIVEPVAGNMGLVLPEPGFLEGLRQITKRYGALLIFDEVISGFRFCFGGYQNIVNIEPDLTTLGKIIGGGLPVGAYGGKKEIMERIAPEGDVYQAGTLSGNPLAMAAGSATLKILRAGKCYELLESTAASLCGQLNQILAQHDGLLSMNRVASLFSLFFTGDKVRDYSSVMRSDTGKYASFHQQLLQGGVYFPPSQFEVCFISAAHDEGDVEKTLKTIDKALQQTMVEQ
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_SHESR
Sequence: MRLTDIEIEQALDNGTIVIEPRPSNDAISGVSVDVRLGGQFRVFKDHTAPFIDLSGPSPEVQAALDRVMSEIIEIPDGEAFFLHPGELALAVTYESVTLPADIVGWLDGRSSLARLGLMVHVTAHRIDPGWQGKIVLEFYNSGKLPLALRPRMTIGALNFERLSGPVARPYNKRKNAKYKDQQDAVASRISQD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RUVB_BURA4
Sequence: MIETDKLAAERIIAATPSSSHEEVFERALRPRQLDDYVGQEKVRGQLEIFIEAAKRRSEPLDHVLLFGPPGLGKTTLAHIIAREMGVNLRQTSGPVLERAGDLAALLTNLEANDVLFIDEIHRLSPVVEEILYPALEDYQIDIMIGEGPAARSVKLDLQPFTLVGATTRAGMLTNPLRDRFGIVARLEFYDADQLARIVRRSASLLNAHIDPSGALEIAKRSRGTPRIANRLLRRVRDFAEVKADGQITAAVADAALAMLDVDPVGFDLMDRKLLEAILHKFDGGPVGIDNLAAAIGEERDTIEDVLEPYLIQQGFLQRTPRGRVATLLTYRHFGLSAPDAGNERGMWDTPAGK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PURT_BORA1
Sequence: MSSFPAPVLGTPLSPSATRVMLLGSGELGKEVIIALQRLGVEVIAVDRYADAPGHQVAHRAHVVSMTDPAALRAVIEQERPHIIVPEIEAIATDLLVELEQEGVARVTPTARAARLTMNREGIRRLAAETLGLPTSPYQFVDTQDALQQAIDGGIGYPCVIKPVMSSSGKGQSVIRGPGDLDAAWRYAQEGGRVGGGRAIVEGFIDFDYEITLLTVRARGVDGQIETHFCDPIGHKQVDGDYVESWQPHPMSPAALARAREIALGVTGNLGGLGIFGVELFVAGDQVWFSEVSPRPHDTGMVTMITQVQNEFELHARALLGLPVDTALRQPGASSVIYGGLDGRGVTFHGVAQALAEPGTDVRLFGKPEAFVKRRMGVGLAVADTLDAAREKARRVSAAVSVKAA
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: TRXR2_DROME
Sequence: MSTIKFLRSSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERGIPFLGTTIPKAVERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDDKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGRDPTPASCCS
What is the function of this protein?
Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase.  Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span.  Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.
What are the official names of this protein?
Thioredoxin reductase 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ATPB_XANAC
Sequence: MSQGKIVQIIGAVVDVEFPRNEVPKVYHALKVDGTEITLEVQQQLGDGVVRTIALGSTDGLKRNLVATNTERAISVPVGAGTLGRIMDVLGRPIDEAGDVQASDHWEIHRGAPSYEDQSSSTELLETGIKVIDLMCPFAKGGKVGLFGGAGVGKTVNMMELINNIAKAHSGLSVFAGVGERTREGNDFYHEMKDSNVLDKVAMVYGQMNEPPGNRLRVALTGLTMAEYFRDEKDASGKGKDVLLFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKSGSITSIQAVYVPADDLTDPSPATTFAHLDSTVTLSRNIASLGIYPAVDPLDSTSRQMDPLVIGHEHYDTAQRVQQTLQKYKELKDIIAILGMDELSEEDKQSVSRARKIERFFSQPFHVAEVFTGSPGKYVSLKDTIRGFKAICDGEYDHLPEQAFYMVGSIEEAVEKANKMSAKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EF1A_ANIIF
Sequence: HVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSESRFEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEASTKMPWFKGWNVERKEGKAEGKCLIEALDAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGILKPGTIVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKNNPPKGAADFTAQVIVLNHPGQISNGYTPVLDCHTAHIACKFAEIKEKVDRRTGKSTEDNPKSIKSGDAAIVNLVPSKPLCVESFQEFPPLGRFAVR
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_DESVH
Sequence: MKVRPSVKKICPKCKVIRRRGVLRVICENPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: PYRH_RUEPO
Sequence: MTSSTSPETPSDPSQTRYKRVMLKISGEALMGDQGFGLHPPTVKRIAHEIKTVHDMGVEICMVIGGGNIFRGLSGAAQGMERTTADYMGMLATVMNALGMQAALEGLGVFTRVISAIRMDEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMACEAIFMGKNGVDGVYDKDPALHDDAVRYDEISYDEVLAKRLKVMDASAIALARDNNLPLIVFSLDTAGGFRGILAGEGTYTKVQG
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.