PharMolix/UniProtQA huggingface dataset:
Protein: MRAY_STRA5
Sequence: MFLSIMAGVIAFVLTVIAIPRFIKFYQLKKIGGQQMHEDVKQHLAKAGTPTMGGTVFLIVALLVSLIFSIILSKENSGNLGATFGILSVVLIYGIIGFLDDFLKIFKQINEGLTPKQKMSLQLIAGLIFYFVHVLPSGTSAINIFGFYLEVGYLYAFFVLFWVVGFSNAVNLTDGIDGLASISVVISLITYGIIAYNQTQFDILLIIVIMIGALLGFFVFNHKPAKVFMGDVGSLALGAMLAAISIALRQEWTLLFIGFVYVFETSSVMLQVAYFKYTKKKTGVGKRIFRMTPFHHHLELGGVSGKGNKWSEWKVDAFLWAIGIFMSAITLAILYL
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFTS_LIMRJ
Sequence: MAEIKAAQVMQLRKKSGAGIMDAKKALVASDGDMDKAMDYLREKGIAKAAKKSDRVAAEGLADIAVNGNTAAIVELNSETDFVAASEPFKDLLKKVTKLISENKPANVEEALEIKTENGTLNDDIISTTQKTGEKVSLRRFTVVEKDDGDSFGAYLHQGGQIAALVVLEGADDATAKDVAMHVAAINPEFMTRDDVSQERLDHERAIFKEETLNEGKPEKIVDKIVEGRLNKFLSQICLADQDFVKDSDQTVEQYVSSKNGKLKSFIRYEVGEGIEKKQDDFAQEVKDQMN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG20_YEAST
Sequence: MSDLNDVQENAKLNSETRNTGKAEPPHGTTEYVAEAEISKNGVGSPKKSPKKGKVGKGDNNKVETELVHTALLEKDNPFMEEGPTGFTKSALLEIPGMRSHNLKNPNEDYEDDSEGLLPLNQESNAETCRTSLSGSINSMNGETSASEEPSVSNRKKSARIHILEAKRVSEGQGRAYIAYVIQFENSTVQRRYSDFESLRSILIRLFPMTLIPPIPEKQSIKNYGKSITGSSSKYLLPSEGSGSVDLSLSVIHASVNNSDEKLIRHRIRMLTEFLNKLLTNEEITKTSIITDFLDPNNHNWHEFVNSSSTFSSLPKSILQCNPLDPTNTTRIHAMLPIPGSSSQLLLNKESNDKKMDKERSKSFTNIEQDYKQYENLLDNGIYKYNRRTTKTYHDLKSDYNEIGEVFAQFAHEQAQVGELAEQLSYLSNAFSGSSISLEKLVGRLYYNINEPLNESVHMATSARELIKYRKLKYLQNEMIKKSLNSKRAQLEKLEAQNNEYKDVDKIIDNEMSKSHTINLERPNNNTGSGGKSYGGKLFNGFNKLASMVKDSVKYQETDPHTASINLKKEIEQLSESLEVTENDLEVISKVIKNDQLPKFSKEREVDLSEILKHYSRYMRNYARQNLEIWKEVKRHQDFA
What is the function of this protein?
Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  Functions in protein retrieval from the endocytic pathway.  Required for proper sorting of the v-SNARE protein SNC1.
What are the official names of this protein?
Autophagy-related protein 20, Cytoplasm to vacuole targeting protein 20, Sorting nexin-42.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: AAP6_ARATH
Sequence: MEKKKSMFVEQSFPEHEIGDTNKNFDEDGRDKRTGTWMTGSAHIITAVIGSGVLSLAWAIAQLGWVAGPAVLMAFSFITYFTSTMLADCYRSPDPVTGKRNYTYMEVVRSYLGGRKVQLCGLAQYGNLIGITIGYTITASISMVAVKRSNCFHKNGHNVKCATSNTPFMIIFAIIQIILSQIPNFHNLSWLSILAAVMSFCYASIGVGLSIAKAAGGGEHVRTTLTGVTVGIDVSGAEKIWRTFQAIGDIAFAYAYSTVLIEIQDTLKAGPPSENKAMKRASLVGVSTTTFFYMLCGCVGYAAFGNDAPGNFLTGFGFYEPFWLIDFANVCIAVHLIGAYQVFCQPIFQFVESQSAKRWPDNKFITGEYKIHVPCCGDFSINFLRLVWRTSYVVVTAVVAMIFPFFNDFLGLIGAASFWPLTVYFPIEMHIAQKKIPKFSFTWTWLKILSWTCFIVSLVAAAGSVQGLIQSLKDFKPFQAP
What is the function of this protein?
Amino acid-proton symporter.  Stereospecific transporter with a broad specificity for tryptophan, proline, and neutral and acidic amino acids.  Has an affinity for aspartate in a physiological range.  Involved in the uptake of amino acids diffusing out of the xylem tracheids into the xylem parenchyma.
What are the official names of this protein?
Amino acid permease 6, Amino acid transporter AAP6.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ABCB4_DICDI
Sequence: MNSLLRCCLIKPINIKNTTSFINKLNPKSIIQKSNNYNNINKNILNKFKDSSSNYFINSNKILEICNNNNNNNKYNVNKRNYSSSSNSGNNNNNNYNNKNNNNNNESFYKKFENSFEIKRIKDILFIIVGTFVIFKIYDNKIGIVFCENEIDKETILNDPYDKIPNEIIVELKDSAKDDNIIEESDEDDGIKKISSFKLFFKTIGNDIWLFGFGIITAFFSSWVGLQIPKVFGVLIDCTKNGDSLQGPAIQAIFILLAQAGLNFLYSTMISVACERYSARLRSTLFGAMLEQEIGFFDQNSTGDLINRLSSDVQLVRSALKHSVSLGVKSFGQIVGGVISLILISPKLSLGMMTILPTMVSVGTFYAGWLKSLSVRSQRAQAQSTIVAEEAIGNIRTVQAFSNQHYESERFIEKNQHSLALSTESGVQIGIFQGVTSLALNSVSLLVYWYGGTLVSRGEMTGGQLTSFIIHTMNMQSSFSQLSILFTQIMSAMGGMQRITELINRVPLINSNQGFKLRELKGEIKFINVDFKYPTRPHVHVLNGLNLTLKPGQVVALAGSSGGGKSTIAGLLERFYDISNGDITIDGYSIKQLNAKWLRSRIGIVSQEPSLFATTILENLRYGNPNATEDEIIEAAKLANAHQFISNFPKGYETIVGERGVQLSGGQKQRIAIARAILKNPQIIILDEATSALDSQSELLVQTALDNLMKGRTTLVIAHRLSTVQNADLIGVLSHGKIAEFGNHNELMNHKGLYYKLVQRQLSQQQQ
What are the official names of this protein?
ABC transporter B family member 4, ABC transporter ABCB.4.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: BLC97_ECOLX
Sequence: MMTQSIGRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTMTLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDPRDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGSGDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAESRRDILAAAAKIVTHGF
What is the function of this protein?
Is probably capable of hydrolyzing cephalosporins such as ceftriaxone and ceftazidime, thus conferring resistance to these antibiotics.
What are the official names of this protein?
Beta-lactamase CTX-M-97.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: UVRC_STAAU
Sequence: MEDYKKRIKNKLNVVPMEPGCYLMKDRNDQVIYVGKAKKLRNRLRSYFTGAHDAKTTRLVGEIRRFEFIVTSSETESLLLELNLIKQYQPRYNILLKDDKSYPFIKITKEKYPRLLVTRTVKQGTGKYFGPYPNAYSAQETKKLLDRIYPYRKCDKMPDKLCLYYHIGQCLGPCVYDVDLSKYAQMTKEITDFLNGEDKTILKSLEERMLTASESLDFERAKEYRDLIQHIQNLTNKQKIMSSDKTIRDVFGYSVDKGWMCIQVFFIRQGNMIKRDTTMIPLQQTEEEEFYTFIGQFYSLNQHILPKEVHVPRNLDKEMIQSVVDTKIVQPARGPKKDMVDLAAHNAKVSLNNKFELISRDESRTIKAIEELGTQMGIQTPIRIEAFDNSNIQGVDPVSAMVTFVDGKPDKKNYRKYKIKTVKGPDDYKSMREVVRRRYSRVLNEGLPLPDLIIVDGGKGHMNGVIDVLQNELGLDIPVAGLQKNDKHQTSELLYGASAEIVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLKSILDDIDGIGSKRKTLLLRSFGSIKKMKEATLEDFKNIGIPENVAKNLHEQLHK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2346_CORDI
Sequence: MVNTIGFDREKYIEMQSQHIRERREALGGKLYLEMGGKLFDDMHASRVLPGFTPDNKIAMLDRIKDEVEILVCINAKDLERHKIRADLGISYEEDVLRLVDVFRDRGFLVEHVVLTQLENDNRLALAFIERLQRLGIKVSRHRVIPGYPTDMDRIVSDEGFGLNEYAETTRDLVVVTAPGPGSGKLATCLSQVYHEHKRGVAAGYAKFETFPIWNLPLEHPVNLAYEAATVDLNDANVIDHFHLAAYGEQTVNYNRDVEAFPLLKTLLERLMGESPYQSPTDMGVNMAGNCISDDAACRHASEQEIIRRYFKALVEEARTGKDSTQSDRAAVVMAKAGIKASQRVVVEPARQVEERTSLPGCAIELVDGSIITGATSDLLGCSSSMLLNALKHLAGIDDAIHLLSPESIEPIQTLKTVHLGSSNPRLHTDEVLIALSVSAATDSNAQKALDQLKNLRGCDVHTTTILGSVDEGIFRNLGVLVTSDPKFQKNKLYQKR
What are the official names of this protein?
UPF0371 protein DIP2346.
What is the protein family that this protein belongs to?
Belongs to the UPF0371 family.
Protein: MEMA_METTR
Sequence: MAISLATKAATDALKVNRAPVGVEPQEVHKWLQSFNWDFKENRTKYPTKYHMANETKEQFKVIAKEYARMEAAKDERQFGTLLDGLTRLGAGNKVHPRWGETMKVISNFLEVGEYNAIAASAMLWDSATAAEQKNGYLAQVLDEIRHTHQCAFINHYYSKHYHDPAGHNDARRTRAIGPLWKGMKRVFADGFISGDAVECSVNLQLVGEACFTNPLIVAVTEWASANGDEITPTVFLSVETDELRHMANGYQTVVSIANDPASAKFLNTDLNNAFWTQQKYFTPVLGYLFEYGSKFKVEPWVKTWNRWVYEDWGGIWIGRLGKYGVESPASLRDAKRDAYWAHHDLALAAYAMWPLGFARLALPDEEDQAWFEANYPGWADHYGKIFNEWKKLGYEDPKSGFIPYQWLLANGHDVYIDRVSQVPFIPSLAKGTGSLRVHEFNGKKHSLTDDWGERQWLIEPERYECHNVFEQYEGRELSEVIAEGHGVRSDGKTLIAQPHTRGDNLWTLEDIKRAGCVFPDPLAKF
What is the function of this protein?
Responsible for the initial oxygenation of methane to methanol in methanotrophs.  It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds.
What are the official names of this protein?
Methane monooxygenase component A alpha chain, Methane hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the TmoA/XamoA family.
Protein: RECR_ENT38
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQDVCNICTNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLESETLTEVILATNPTVEGEATANYIGELCAQYGVSASRIAHGVPVGGELEMVDGTTLSHSLAGRHKLIF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: HBA_PTEPO
Sequence: VLSSTDKSNVKAAWDKVGGNVGEYGAEALERMFLSFPTTKTYFPHFDLAHGSSQVKAHGKKVGDALTNAVGHMDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLANHLPNDFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: YQGB_ECOUT
Sequence: MKKKPVAQLERQHSLLENPCAYGLLSQFQAAIVVNCFTLNKII
What are the official names of this protein?
Uncharacterized protein YqgB.
What is the protein family that this protein belongs to?
Belongs to the YqgB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_NEIMA
Sequence: MKPTIALVGRPNVGKSTLFNRLTRTKDALVHDLPGLTRDRHYGHGKVGSKPYLVIDTGGFEPVVDSGILHEMAKQTLQAVDEADAVVFLVDGRTGLTPQDKIIADRLRQSPRPVYLAVNKGEGGNRAVLAAEFYELALGDPYVISGAHGDGVYYLIEDILETFPEPEKEEEEAKHPVFAVIGRPNVGKSTLVNAILGEERVIAFDMAGTTRDSIHIDFEREGKPFTIIDTAGVRRRGKVDEAVEKFSVIKAMQAVEAANVAVLVLDAQQDIADQDATIAGFALEAGRALVVAVNKWDGISEERREQVKRDINRKLYFLDFAKFHFISALKERGIDGLFDSIQAAYNAAMIKMPTPKITRVLQSAIERQQPPRAGLVRPKMRYAHQGGMNPPVIVVHGNSLHAISDSYTRYLTQTFRKAFNLQGTPLRIQYNVSENPYENADDKPKKKPLRRVSLSNRIEKREGRKEEKNRFKKKTKVSVKKQFSK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PG073_VARV
Sequence: MELVNIFLETDAGRVKFVIKNTDDVCASELINKFVELLSEYIHIDQSEFYLVVKDKDIFYFKCDKGSISIVSNEFYVFDEPLLFVKDYTNVTGVEFIVTETMPCRIIPKNNHAVISVVTNHKFYNGLSL
What are the official names of this protein?
Core protein OPG073, Protein E11.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG073 family.
Protein: RS12_LATSS
Sequence: MPTINQLVRKGRKSRTSKSDAPALNFGYNSMKKKATDNPAPQKRGVATRVGTMTPKKPNSALRKYARVRLSNLIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHVIRGALDTAGVDGRMQSRSKYGTKRPKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ATPA_PROM5
Sequence: MVSIRPDEISSILKQQITDYDQSVSVSNVGTVLQIGDGIARIYGLDQVMAGELLEFEDGTEGIALNLEDDNVGAVLMGEALGVQEGSNVKSTGKIASVPVGEAMKGRVVNPLGQPIDGKGEIPTSDNRLIEEMAPGIIKRRSVHEPMQTGITSIDAMIPVGRGQRELIIGDRQTGKTAIAIDTIINQKGQDVVCVYVAIGQKSASVANVVEVLREKGALDYTVVVSAGASEAAALQYLAPYTGAAIAEHFMYQGKATLVIYDDLTKQAQAYRQMSLLLRRPPGREAYPGDVFYCHSRLLERAAKLSDDMGGGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLSADLFNSGLRPAINVGISVSRVGGAAQTKAIKKIAGTLKLELAQFDELAAFSQFASDLDEATQQQLERGKRLRELLKQAQFSPLNLAEQVAVVYAGVKGLIDEVPVEDVTKFAAELREYLKLNKAEFIEEILKEKKLNEGLETTLTEVIKEVKSSMLATV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: YEJL_SALNS
Sequence: MPQLSRYSDEHVEQLLSELLSVLEKHKAPTDLSLMVLGNMVTNLINTSVAPAQRRAIANSFARALQSSISEDNAH
What are the official names of this protein?
UPF0352 protein YejL.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: ST7_FELCA
Sequence: MAEAGTGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAMIDIFCSAEFRDWNCKSIFMRVEDELEIPPAPQSQHFQN
What are the official names of this protein?
Suppressor of tumorigenicity 7 protein.
What is the protein family that this protein belongs to?
Belongs to the ST7 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CLSA_ECOK1
Sequence: MTTVYTLVSWLAILGYWLLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLAVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAEENSSVAAPLFKLCERRQGIAGVKGNQLQLMTESDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWPELMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMIMIDNYIAYTGSMNMVDPRYFKQDAGVGQWIDLMARMEGPIATAMGIIYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTAAYSAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSMLVGWASRAFFTELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLAIDDKGFGADLAAVQDDYISRSRLLDARLWLKRPLWQRVAERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL21_ECO24
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: KHSE_BRUAB
Sequence: MAVYTDINEIELGAFLRHYDIGTLTSYKGIAEGVENSNYLLHTSSGSFILTLYEKRTNREDLPFFLGLMQHLAKRGLECPQPVVRNDGAMIGQLAGRPAAIVTFLEGMWMRRPTVAHCEAVGEGLAHMHLAGADFPMRRRNGLTLPDWRPLWNLSRKCADTVERGLVAETEADLDFLEKNWPADLPQGVIHADLFPDNAFFLGDRLSGFIDFYFACTDILAYDVAVCLNAWCFEKDFSYNRTKGAALLRGYTSVRPLSEAEADALLVLARGAAVRFMLTRLYDWLTVPAGSFVVKKDPMEYVRRMRFHRQIESAAEYGLEMQGVAA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: CASP3_PIG
Sequence: MENNKTSVDSKSIKTLETKILHGSKSMDSGISLDVSYKMDYPEMGLCIIINNKNFDKNTGMACRSGTDVDAANLRETFTNLKYEVRNKNDLTREEILELMHSVSKEDHSKRSSFICVLLSHGEEGKIFGTNGPVDLKKLTSFFRGDCCRTLTGKPKLFIIQACRGTELDCGIETDSGTEDDMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAALKQYVHKLELMHILTRVNRKVAVEFESFSTDSTFHAKKQIPCIVSMLTKELYFYH
What is the function of this protein?
Involved in the activation cascade of caspases responsible for apoptosis execution.  At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond.  Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain.  Cleaves and activates caspase-6, -7 and -9.  Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).  Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity).  Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress.  Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction.  Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity).  Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).
What are the official names of this protein?
Caspase-3, CASP-3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRL23_ARATH
Sequence: MDSLSSMGFQTASFFLILLFLFYHLPCVPSQQERSRLCKPFQCGDITVGFPFWGENRQSDCGHFSLKLNCNKPSNTTSLTISGHNYSVLHIDNKSNILSLSRQDFSGPFCSASFSSTPLRSDLFQNLQPYRNLTVFYMCDPRRHFFGNFTCPVKGLGSVVQNSTYRKLCDKSFSVTVPTSYVPEEEALNLTHLESVLRKGLEVKLKISEMSGQECVTTDGNSGFTRFCCTNVSGPEISCLTSITTMNNGTYSDNRPFLVTIGTVLGSILCVCVVLFLAFYLNERRIAKAARIQHLEALGTLRGYNYKQIKKITKSFTEVVGRGGFGTVYRGRLRDGRKVAVKVLKDSKGNCEDFINEVASMSQTSHVNIVTLLGFCYEGSKRAIIYEFLENGSLDQSLNLDVSTLYGIALGVARGLEYLHYGCKTRIVHFDIKPQNVLLDENLRPKVADFGLAKLCEKQESILSLLDTRGTIGYIAPELFSRMYGSVSHKSDVYSYGMLVLEMIGARNKERVQNADPNNSSAYFPDWIYKDLENFDNTRLLGDGLTREEEKNAKKMILVGLWCIQFRPSDRPSMNKVVEMMEGSLDSLDPPPKPLLHMPMQNNNAESSQLSVESSIYSEV
What are the official names of this protein?
LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 2.3, Probable receptor-like serine/threonine-protein kinase LRK10L-2.3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: HPSE_RAT
Sequence: MLRPLLLLWLWGRLGALTQGTPAGTAPTKDVVDLEFYTKRLFQSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPNKEPTSEERSYWQSQDNNDICGSERVSADVLRKLQMEWPFQELLLLREQYQREFKNSTYSRSSVDMLYSFAKCSRLDLIFGLNALLRTPDLRWNSSNAQLLLNYCSSKGYNISWELGNEPNSFWKKAHISIDGLQLGEDFVELHKLLQKSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRVATKEDFLSSDVLDTFILSVQKILKVTKEMTPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSAQLGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPKVLMSRVKGPDRSKLRVYLHCTNVYHPRYREGDLTLYVLNLHNVTKHLKLPPPMFSRPVDKYLLKPFGSDGLLSKSVQLNGQTLKMVDEQTLPALTEKPLPAGSSLSVPAFSYGFFVIRNAKIAACI
What is the function of this protein?
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.  Participates in extracellular matrix (ECM) degradation and remodeling.  Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group.  Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety.  It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes.  Facilitates cell migration associated with metastasis, wound healing and inflammation.  Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas.  Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII.  Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity.  Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion.  Heparin increases this AKT1/PKB activation.  Regulates osteogenesis.  Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF.  Implicated in hair follicle inner root sheath differentiation and hair homeostasis (By similarity).
What are the official names of this protein?
Heparanase, Endo-glucoronidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 79 family.
What are the subcellular locations of this protein?
Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium. Associates with lipid rafts (By similarity).
Protein: HIS1_PROMP
Sequence: MITIALPKGALLEDSISIFKKAGLNFSDALLENSRSLTVESKCKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLQESELKVAKLLDLEFGGCHMSLAVKNNSNYLKPTDLPANCKVASKFTKTARAYFDDLNIPVEIVHLTGSVELGPITGMAEAIVDLVATGKTLKENGLSKIDDLFYSTARLIANPLSLRLDSNPLRDVILSIESSKDILNI
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y801_DEIRA
Sequence: MAPFSPASSDVLVIGGGPSGTALSAELAARGLDVQQLAPHPPRPFPATYGAWLGDLPTWARGCAEQVWTDVRAYTGPQPTSLGQPYALLDNAALLRTLRGLADWTWVEGAALHAERSGAGWTVYGAGGERWQTRLVVDASGHGALVSPVRFPGGAALQTAYGVVARFRRPPVTPGSMVWMDYRTPAPELKRGEATFLYAMHLGGDRYFVEETSLIARPAPTRAELRRRLLARLSAQGTPPHATESEEWVAFPMNAQAPAPGGVLAYGAAAGRVHPVSGFQVAGALSDAPGVATAIATALCQGKDAAAAGWAALWSPERRAAREVHLLGVGALLGLERAELPHFFGTFFGLPREQWARFLHPDTDAGTLARTMLRVFAQTGGRVRLPLARAALAQPAASGRALAAAAGLKI
What are the official names of this protein?
Uncharacterized carotenoid cyclase DR_0801.
What is the protein family that this protein belongs to?
Belongs to the lycopene cyclase family.
Protein: M470_ARATH
Sequence: MILNLDTNIFNHGLSRHNILAFSQGFPIGLPCRNWIEVGLRLRLRLLLELAVGNFPQGFKIHLSGSFQAVRLALFSSFTSLRTDELLLIETRPSYLSSVQGLKYYVIFIDNYSQGSVGCSRN
What are the official names of this protein?
Uncharacterized mitochondrial protein AtMg00470, ORF122a.
What are the subcellular locations of this protein?
Mitochondrion.