PharMolix/UniProtQA huggingface dataset:
Protein: WRK76_ORYSJ
Sequence: MDAAWRGGVGCSPVCLDLCVGLSPVREPSAARHELLDRPAGCRGGGDSKSMTNDEAKIVEAKVTQMSEENRRLTEVIARLYGGQIPRLGLDGSASPPRPVSPLSGKKRSRESMETANSCDANSNRHQGGDADHAESFAADDGTCRRIKVSRVCRRIDPSDTSLVVKDGYQWRKYGQKVTRDNPSPRAYFRCAFAPSCPVKKKVQRSAEDSSLLVATYEGEHNHPHPSPRAGELPAAAGGAGGSLPCSISINSSGPTITLDLTKNGGAVQVVEAAHPPPPPDLKEVCREVASPEFRTALVEQMASALTSDPKFTGALAAAILQKLPEF
What is the function of this protein?
Transcription repressor.  Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element.  Regulates, probably indirectly, the activation of defense-related genes during defense response (By similarity).  Modulates plant innate immunity against X. oryzae pv.  oryzae (Xoo) (PubMed:21961049).
What are the official names of this protein?
WRKY transcription factor WRKY76, OsWRKY76.
What is the protein family that this protein belongs to?
Belongs to the WRKY group II-a family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CALD_PENDC
Sequence: MFGLFRSKAPEAPPKHPTDTIIPLNAADDTEVLRSVVVVLSYRFDDVLDPVKLKSSFEKLLDRPGWRKIGARLRLNDNGRLEYHIPERYDEKRPIVTWSHVSHNVSVLKHPLSSKLPRASARPAVVGDPNDFDELTSSPEAPKTLHDYLTRDVPQLCLHVVSFTDSTLVSISLPHTLTDGTGGAQIYRCWALVLQDRDDEVPPFHGYDSDPLATFGETSSQPYMYDPKLLTGWRKWLFILYQVYDGWRYRTSSRIVCVPGPYLAAQRKKAIEEIRAETGNDKAFVSDNDVLTAWFTRLAVGHYPRNSNLTVRIMNAFALASVLGNDRLPSTKAFISNAATEIYTFLSVRDFFTKPLSYAAYAIRRSMMEGGTREQVEALQAVKKQTLAREGHTWPIFGDASMEMMSYSNWTKGKYFETDFSAAIVKEGFAREARAEKPGFASMVQFNAWSTKFDLRNLMPIMGKDAAGNYWLQGPLRDVVWKRIEKELREEPLQ
What is the function of this protein?
Transcription co-regulator that might be involved in the regulation of the expression of the gene cluster that mediates the biosynthesis of calbistrins and related compounds such as decumbenones.  Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have bioactivity against leukemia cells.  It consists of two polyketides linked by an ester bond: a bicyclic decalin containing polyketide and a linear 12 carbon dioic acid structure.
What are the official names of this protein?
Transcriptional regulator calD, Calbistrin biosynthesis cluster protein D.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEMW_BUCAI
Sequence: MFTLPPISLYIHIPWCLKKCGYCDFYSYVSKEIIPENKYIEHLLRDFERDLSLINNRNINTIFIGGGTPSLLKNTSIKNLLNGIKKRKIISKNIEISIEANPKTLEYQNFIQYKNSGINRFSLGIQTFNSKMLKKIERTYNSKDAMNAIIESKKISDNINLDLMYGLPGQSLEEALSDLQIAIQCNPSHISWYQLTIEPNTVFYAKKIQTPHQDVVFNMLIEGDKLLKKAGYKKYEISSYSKFNYQCQHNLNYWNFGDYIGIGCGSHGKITQKNGEIIRTIKNKNINDFLSGKYINSVYQVSKRDKIFEYFMNVFRLYKPIFKKHFRENTNIEESFIEKNIQIAIQEGFLINQSDCWHTTKKGKNFLNSLLEIFLK
What is the function of this protein?
Probably acts as a heme chaperone, transferring heme to an unknown acceptor.  Binds one molecule of heme per monomer, possibly covalently (By similarity).  Binds 1 [4Fe-4S] cluster.  The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).
What are the official names of this protein?
Heme chaperone HemW, Oxygen-independent coproporphyrinogen-III oxidase-like protein BU550.
What is the protein family that this protein belongs to?
Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_AGRFC
Sequence: MRISIFAVGRLKSGPEKDLAARYIERLAKTGPAIGLEFSRVIEVGESRASNAETRKREEAAMLEKHLADGAVLVLLDERGKALDSPAFASLFGDLRDSGKRDLVIAIGGADGLDSALYDKATAVLNLGKLTWPHQIVRILIAEQLYRAVTILSGHPYHRV
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIAA_SHIFL
Sequence: MQERIKACFTESIQTQIAAAEALPDAISRAAMTLVQSLLNGNKILCCGNGTSAANAQHFAASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHRSARIQEMHMLTVNCLCDLIDNTLFPHQDD
What is the function of this protein?
Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
What are the official names of this protein?
DnaA initiator-associating protein DiaA.
What is the protein family that this protein belongs to?
Belongs to the SIS family. DiaA subfamily.
Protein: ELP3_ORYSJ
Sequence: MATAVAAAGGGGGGEQPRRRKPAPGRGGVVLPAGLSEEEARVRAIAEIVSAMGELSRRGEDVDLNALKSAACRRYGLARAPKLVEMIAAVPEADRAALLPRLRAKPVRTASGIAVVAVMSKPHRCPHIATTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYNPYVQARSRIDQLKRLGHSVDKVEFILMGGTFMSLPADYRDYFIRNLHDALSGHTSANVEEAVCYSEHGAVKCIGMTIETRPDYCLGPHLRQMLSYGCTRLEIGVQSTYEDVARDTNRGHTVAAVADCFCLAKDAGFKVVAHMMPDLPNVGVERDLESFREFFENPAFRADGLKIYPTLVIRGTGLYELWKTGRYRNYPPELLVDIVARILSMVPPWTRVYRVQRDIPMPLVTSGVEKGNLRELALARMEDLGLKCRDVRTREAGIQDIHHKIRPDEVELVRRDYAANEGWETFLSYEDTQQDILIGLLRLRKCGRNVTCPELVGRCSIVRELHVYGTAVPVHGRDADKLQHQGYGTLLMEEAERIARKEHRSKKIAVISGVGTRHYYRKLGYELEGPYMVKCLV
What is the function of this protein?
Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity).  In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
What are the official names of this protein?
Elongator complex protein 3, Elongator component 3, tRNA uridine(34) acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ELP3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IL36A_MOUSE
Sequence: MNKEKELRAASPSLRHVQDLSSRVWILQNNILTAVPRKEQTVPVTITLLPCQYLDTLETNRGDPTYMGVQRPMSCLFCTKDGEQPVLQLGEGNIMEMYNKKEPVKASLFYHKKSGTTSTFESAAFPGWFIAVCSKGSCPLILTQELGEIFITDFEMIVVH
What is the function of this protein?
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response.  Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.  Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation.  Induces the production of pro-inflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs).  Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II.  Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes.  May play a role in pro-inflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages.  May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells.  May be involved in CD4(+) T-cell proliferation.  Induces NF-kappa B activation in macrophages.
What are the official names of this protein?
Interleukin-36 alpha, FIL1 epsilon, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6, Interleukin-1 homolog 1, IL-1H1.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: SELO_YEAST
Sequence: MGEKRTIIKALKNSAASHFIKKLTADTSLSSIQEAINVVQQYNATDPVRLKLFHTPRMVSQGAHFAFCLPTKKPHYKPLLLSQNALDEFNLVQDQDLEKILSGEKVYYSDSIFPYSTVYSGFQFGSFAAQLGDGRVVNLFDLKDKCSGQWQTFQLKGAGMTPFSRFADGKAVLRSSIREFIMSEALHSIGIPSTRAMQLTLLPGTKAQRRNQEPCAVVCRFAPSWIRLGNFNLFRWRHDLKGLIQLSDYCIEELFAGGTQFEGKPDFNIFKRDFFPDTETKIDEQVEKDETEVSTMTGDNISTLSKYDEFFRHVVSLNANTVAHWQAYGFANGVLNTDNTSIMGLTIDYGPFAFLDKFEPSFTPNHDDTAKRYSFANQPSIIWWNLQQFAKDLACLLGPEARDLELLLKGELNSVDDALEKTMIERVQKLVELSANEYKYVFTTRYAQIMSQRLGVDLDLEKCMSSTNLKDIEHAAEKAKEFCDVIVEPLLDILQATKVDYNNFFIHLQNYKGPFFIKDKSDTATLFGAFDEEYLGMFFNSKQLQQMAETEEAFAAGEKVFDANGELRLLNEKLQEIRNWTQDYLTLVPPTETAARASLAKKANPLFVPRSWVLEEVVDDLMYSQRDGLQDPSSELDTSALKKLYLMSVNPYDRTKWDVTLRPELETKWADLSHQDDAKFMMQASCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Tyr residues of target mitochondrial proteins (AMPylation) (PubMed:30270044).  Involved in redox homeostasis by regulating the cellular response to oxidative stress (PubMed:30270044).  Regulates protein S-glutathionylation levels possibly by AMPylation of deglutathionylation enzymes such as glutaredoxins (PubMed:30270044).
What are the official names of this protein?
Protein adenylyltransferase SelO, mitochondrial, Selenoprotein O, SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: PLSB_XANCP
Sequence: MPEQNPLPFPDGQSAPPSPAGAETGATAAALPPAAPVALDAPAPAAPVLAPARVAKRPWWARLLGRLADPWLSLTIEPEQPGRYDDGKPVVYVLEDYGLSNALILDKACREAGLPSPLVPLPGDPLERKRAYLALSRRSSSNSLIPEQRGGKTHSDSLAKLLQAHRVRADLDVHLVPVSIFVGRAPDKQSGWFAVLFSENWALVGRFRRLLSVLLNGRTTIVRFAPPISLRQTMAEGLPPERTLRKLQRVLRTHFRRIREAVIGPDLSTRRLLVDQVLAADSVREAIATQAKRDNSKPVDAWRKAHAYAWEIAADYSSPVVRSASFLLTHVWNRIYAGVLVHHLDKLKQAAPGHEVVYVPSHRSHMDYLLLSYLLYERGIVPPHIVAGINLNLPVVGTLLRKGGAFFIRRSIRGNALYSAVLSEYVAQLVAGGYSIEYFVEGGRSRTGRLLQPKGGMIAMTLRAYLRQPRKPVLFQPVYIGYEKLMEGNSYLDELTGRPKEKESIWGLLWSIPKVLKQNYGQVVVNFGEPIALNDVLAKHAPEWNGEPLPDDEKPTWLAPAVDTLATQIQTRINCAADVNPINLLALALLSTPKHAMGEADLIAQIELCKKLLAEMPYSDRVTVTPHTPARIITHAEEINVLTRVSHPLGDVLSVSGDTAVLLSYFRNNVLHLFTASSWVACCFQNNRRMSRAGLLRLGRTVYPFLQAELFLPWSEDRFAERIEQTIDMFVREGLLLNVTDDDGGILARNTGQTDEVFRLRAIGHSLQQAFERYYIAISVLVKNGPGVLGAGELESLCQQAAQRLSLLYAPAAPEFFDKTLFRSFIQKLRELRLVWPDENSKLMFDERLDAWAKDAKFILGRELRHTIERVSPEAAKPDVVSPPAE
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GP_SFTS
Sequence: MMKVIWFSSLICFVIQCSGDSGPIICAGPIHSNKSADIPHLLGYSEKICQIDRLIHVSSWLRNHSQFQGYVGQRGGRSQVSYYPAENSYSRWSGLLSPCDADWLGMLVVKKAKGSDMIVPGPSYKGKVFFERPTFDGYVGWGCGSGKSRTESGELCSSDSGTSSGLLPSDRVLWIGDVACQPMTPIPEETFLELKSFSQSEFPDICKIDGIVFNQCEGESLPQPFDVAWMDVGHSHKIIMREHKTKWVQESSSKDFVCYKEGTGPCSESEEKTCKTSGSCRGDMQFCKVAGCEHGEEASEAKCRCSLVHKPGEVVVSYGGMRVRPKCYGFSRMMATLEVNQPEQRLGQCTGCHLECINGGVRLITLTSELKSATVCASHFCSSATSGKKSTEIQFHSGSLVGKTAIHVKGALVDGTEFTFEGSCMFPDGCDAVDCTFCREFLKNPQCYPAKKWLFIIIVILLGYAGLMLLTNVLKAIGIWGSWVIAPVKLMFAIIKKLMRTVSCLMRKLMDRGRQVIHEEIGENREGNQDDVRIEMARPRRVRHWMYSPVILTILAIGLAESCDEMVHADSKLVSCRQGSGNMKECVTTGRALLPAVNPGQEACLHFTAPGSPDSKCLKIKVKRINLKCKKSSSYFVPDARSRCTSVRRCRWAGDCQSGCPPHFTSNSFSDDWAGKMDRAGLGFSGCSDGCGGAACGCFNAAPSCIFWRKWVENPHGIIWKVSPCAAWVPSAVIELTMPSGEVRTFHPMSGIPTQVFKGVSVTYLGSDMEVSGLTDLCEIEELKSKKLALAPCNQAGMGVVGKVGEIQCSSEESARTIKKDGCIWNADLVGIELRVDDAVCYSKITSVEAVANYSAIPTTIGGLRFERSHDSQGKISGSPLDITAIRGSFSVNYRGLRLSLSEITATCTGEVTNVSGCYSCMTGAKVSIKLHSSKNSTAHVRCKGDETAFSVLEGVHSYTVSLSFDHAVVDEQCQLNCGGHESQVTLKGNLIFLDVPKFVDGSYMQTYHSTVPTGANIPSPTDWLNALFGNGLSRWILGVIGVLLGGLALFFMIMSLFKLGTKQVFRSRTKLA
What is the function of this protein?
Structural component of the virion that interacts with glycoprotein N (By similarity).  Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (By similarity).  The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity).  They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (PubMed:23388721).
What are the official names of this protein?
Envelopment polyprotein, M polyprotein.
What is the protein family that this protein belongs to?
Belongs to the phlebovirus envelope glycoprotein family.
What are the subcellular locations of this protein?
[Glycoprotein N]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein C to the Golgi complex, where virion budding occurs. SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein C to the Golgi complex, where virion budding occurs.
Protein: MURG_XANCB
Sequence: MSVEHATPVQQPAHAAASVRPVMILAGGTGGHIFPGLAVAKVLRARGVPVTWLGADGAMETRLVPQHAIQIDTLAISGLRGKGIVKLLGAPVRVMRAVRAAGFVLRKRQPRAVISFGGFAAGPGGLAARLLGVPLLVHEQNRAPGMTNKVLSRFARRVLTGFPGSFAGEEAVGNPVREEIAALPAPATRLIGRGGPVRLLVLGGSQGARALNNAVPAALAALGHPAVDVRHQCGEKLRAEAEAAYAQAAVNASVEPFIADMAAAYAWADLVVCRAGASTLAEVCAAGVGSVLVPFAAAVDDHQTRNAEYLVSAEAAVLLKQDGTLAVRLQQVLQTLLADPARRLAMAQAARTLAKPDAAERIADIILQEAGNGKSGMGNGQSTEQLQEHTVIHQNKRTDQALDAASASLHPIPDSRFPIRTSAGGAQ
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: IP6K1_HUMAN
Sequence: MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTTEREQPRRKHSRRSLHRSGSGSDHKEEKASLSLETSESSQEAKSPKVELHSHSEVPFQMLDGNSGLSSEKISHNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRAESCLDRRSEMRLKHLDMVLPEVASSCGPSTSPSNTSPEAGPSSQPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ
What is the function of this protein?
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).  Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
What are the official names of this protein?
Inositol hexakisphosphate kinase 1, InsP6 kinase 1, Inositol hexaphosphate kinase 1.
What is the protein family that this protein belongs to?
Belongs to the inositol phosphokinase (IPK) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NSL1_HUMAN
Sequence: MAGSPELVVLDPPWDKELAAGTESQALVSATPREDFRVRCTSKRAVTEMLQLCGRFVQKLGDALPEEIREPALRDAQWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIVDIATKRKQYPRKILECVIKTIKAKQEILKQYHPVVHPLDLKYDPDPAPHMENLKCRGETVAKEISEAMKSLPALIEQGEGFSQVLRMQPVIHLQRIHQEVFSSCHRKPDAKPENFITQIETTPTETASRKTSDMVLKRKQTKDCPQRKWYPLRPKKINLDT
What is the function of this protein?
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
What are the official names of this protein?
Kinetochore-associated protein NSL1 homolog.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore (PubMed:15502821, PubMed:16585270).
Protein: GLYA_THEP3
Sequence: MDIEIIRKTDPEIADAIEKELIRQRNKIELIASENFVSRAVMEAMGSPLTNKYAEGYPNKRYYGGCEYVDIAEELARERLKKLFGAEHANVQPHSGAQANMAAYFALIKPGDTVLGMDLAHGGHLTHGSKVNFSGQIYNFVSYGVREDTGYIDYDEVERVAKKHKPKLIVAGASAYPRIIDFKRFREIADKVGAYLMVDMAHIAGLVAAGLHPNPVPYADVVTTTTHKTLRGPRGGAILCKEEYAKAIDKALFPGTQGGPLMHIIAAKAVCFKEALTDEFKEYQKRIVENAKALANALMERGINLVSGGTDNHLMLLDLRNTGITGKELETRLDEVNITCNKNAIPFDPLGPNVTSGVRLGTPAVTTRGMKPEDMVEIADIIVNVIRDENYKEKAKERVANLLKKYPLYEDLI
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_FRACC
Sequence: MTAVAPEGRPLLRIEARNAQTPIERKPSWIRTRLRTGPQYQDVKGLVQSAGLHTVCEEAGCPNIYECWEDREATFLIGGEVCTRRCDFCQIDSGRPAPLDHDEPRRVAESVATMGLRYATVTGVARDDLADGGSWLYAETVRQIHARSADTGVEVLIPDFGGRPDQLGEVFEAAPEVLAHNLETVPRIFRRIRPAFRYERSLDVLRQARQAGLVTKSNLILGLGETAEEIHTALRDLRSAGCELLTVTQYLRPTPRHHPVERWVRPEEFLDWGRVGAELGFSGVMSGPLVRSSYRASRLYQQAMTARDQDRSEMSVPPESVSENSHGQRPSPW
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAZG_MYCS2
Sequence: MIVVLVDPRRPALVPVDAVEFLTGDVQYTEEMPVKVPWSLPSARPAYDGEDAPVLLSSDPEHPVVKARLAAGDRLIAAPEPQPGERLVDAVALMDKLRTSGPWESEQTHDSLRRYLLEETYELFDAVRSGNADELREELGDVLLQVLFHARIAEDAPHHPFSIDDVADALVRKLGNRVPAVLAGESISLDEQLAQWEERKAQEKKVKARASSMDDVPTGQPALALAQKVLARVSQAGLPAELIPASLTSVSVSADTDSENELRTAVLEFMDTVREVEAAVAAGRRGEDVPEELDVAPLGVISEDEWRAYWPGAESSASEAEPEE
What is the function of this protein?
Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides.  It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP).  Also involved in the transcriptional activation of RelA in response to oxidative stress.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphohydrolase, NTP-PPase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside triphosphate pyrophosphohydrolase family.
Protein: DERL2_PONAB
Sequence: MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGHIYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
What is the function of this protein?
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins.  May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome.  May mediate the interaction between VCP and misfolded glycoproteins.  May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
What are the official names of this protein?
Derlin-2, Der1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the derlin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: EFTU_BIFLS
Sequence: MAKEKYERTKPHVNIGTIGHVDHGKTTLTAAISKVLHEEFPDVNPEYDFNQIDSAPEEAARGITINIAHIEYQTEKRHYAHVDCPGHADFVKNMITGAAQMDGAILVVAATDGPMAQTREHVLLARQVGVPKILVALNKCDMVDDEELIELVEEEVRDLLDENGFDRDCPVIHTSAYGALHDDAPDHEKWVQSVKDLMAAVDDYIPTPVHDLDKPFLMPIEDVFTISGRGTVVTGRVERGQLAVNTPVEIVGIRPTQTTTVTSIETFHKTMDACEAGDNTGLLLRGLGREDVERGQVVAKPGSVTPHTKFEGEVYVLTKDEGGRHSPFFSNYRPQFYFRTTDVTGVIELPEGVEMVQPGDHATFTVELIQPIAMEEGLTFAVREGGHTVGSGRVTKILA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_HALSA
Sequence: MSDLESAYRLEYFEEEGFHRRECVSCGAHFWTRDGDRETCGEPPCEDYQFIDNPGFDASYSLTEMRSAMVSYFERAGHDSIDPYPVAANRWRDDVLLTQASIYDFQPHVTSGASPPPANPLVVSQPCIRMQDIDNVGKTGRHTMAFEMLGHHAFNADEGTDYAYDGEVYWKDTAVEHCEGLLADVGVSLDEVTFIEDPWVGGGNAGAAFEVIYRGLELATLVFMSLERDPDGEYEMKDGHTYAEMDRRVVDTGYGVERWTWMSQGTPTVYEAVYPDTIDFLKEQAGIEHTDEEAELVHRASKHAGNLDIDEVADIEDARAGIAAELGVDAERLTELVAPLEDIYAIADHSRVLAYMFGDGIVPSNVGTGYLARMVLRRTKRLVDDIGADVPLDELVDMQADRLGYENRDTIRSIVRSEVEKYGETLERGGRRVEQLAEEYADRGEPVPTDELIELYDSHGIQPGMVADIAADVGATVDAPDDFYSLVAARHDDGDSGAAGGDGGGDDRLADLPETETLYYDDAYGSEFEAVVLDVFEREGEDGDGAFDVVLDQTMFYPEGGGQPADTGVLTGDDHTVDVIDVQERDGVVLHRTTDNPGKGEFVRGQIDTERRRRLMAHHTATHIVVYAARQVLGEHVRQAGAQKGVDSSRIDVTHYERVDRETVKEIERVANEIVRANTSVQCEWPDRHEAEAEYGFDLYQGGIPAGEQIRLVHVDDDVQACGGTHVARTGEIGSIKILNAERVQDGVERLTFAAGAAAVEHVQGQEDDLRAAAEVLDVTPAEVPETAERFFTEWKDRGKTIDDLKEQLAEARASGGGAGEEVDVAGTTAVVQRVDGDMDELQATANALVDGGQVAVVGSGADGAQFVVGVPDGVPVNAGEVVGELAAMVGGGGGGPPDFAQGGGPDAERLDDALSRAADVLGDAASAE
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.