PharMolix/UniProtQA huggingface dataset:
Protein: Y3382_OCEIH
Sequence: MHPKQQRESFRSKQYTGTTSGMCDNYLQANMIILPKEYAFEFLLFCQRNPKSCPIIDVLEEGVTTPQIADADIRTDLPKYRIYRNGQLDKEVTDIKDKWRADFVTFLIGCSFTFEKALIENGIRLLHQEQERVVPMYKTNIPCEKAGRFEGNMVVSMRALEPEEIDKAVKITERFETSHGSPVHIGNPEEIGIKDIDNPDYGESISFDKKKRTPVFWACGVTPQNVGLNVKPPIMIAHAPGHMLITDQLEEK
What are the official names of this protein?
Putative hydro-lyase OB3382.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: THIE_PSEF5
Sequence: MKLRGLYAITDSQLLAGKFLKYVEAALEGGVTLLQYRDKSDDQARRLREAETLLALCERYKTRLIINDDAELAARIGAGVHLGQTDGPLTPARALLGRQAIIGATCHSQLPLAEQAAKEGASYVAFGRFFNSTTKPGAPAASLELLDQARASLHLPICVIGGITLDNAAPLVNHGADLLAVVHGLFGAESAEEVTRRARAFNALFNS
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: MLAE_ECOLI
Sequence: MLLNALASLGHKGIKTLRTFGRAGLMLFNALVGKPEFRKHAPLLVRQLYNVGVLSMLIIVVSGVFIGMVLGLQGYLVLTTYSAETSLGMLVALSLLRELGPVVAALLFAGRAGSALTAEIGLMRATEQLSSMEMMAVDPLRRVISPRFWAGVISLPLLTVIFVAVGIWGGSLVGVSWKGIDSGFFWSAMQNAVDWRMDLVNCLIKSVVFAITVTWISLFNGYDAIPTSAGISRATTRTVVHSSLAVLGLDFVLTALMFGN
What is the function of this protein?
Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Intermembrane phospholipid transport system permease protein MlaE.
What is the protein family that this protein belongs to?
Belongs to the MlaE permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VSR_CVB
Sequence: MDVIVKMLILRKFVEQGNVCPIHLCVDIYKRAFPRSVNKGRSSYARRRRALELGRCHRCYRVYPPLFPEISRCDNRTCVPGISYNSKVRDYILWGVTEVIPHPGYNF
What is the function of this protein?
Suppressor of viral-induced RNA silencing.  The potential mechanism of action is based on sequestering siRNAs (By similarity).
What are the official names of this protein?
RNA silencing suppressor, 12.6 kDa protein, Putative nucleic acid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the carlaviruses nucleic acid-binding protein family.
Protein: PTGA_STAAM
Sequence: MFKKLFGKGKEVQKDIAIYAPLTGEYVKIEDIPDPVFAQKMMGEGFGINPTEGEVVSPIAGRVDNVFPTKHAIGLKADNGLELLVHIGLDTVQLDGEGFEVLVSSGDEVNVGDPLVRFNLEFINNNAKSVISPIIITNTDQAASINIYDENAVIKGETKVIDVTMN
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II complex composed of PtsG and Crr is involved in glucose transport.
What are the official names of this protein?
PTS system glucose-specific EIIA component, EIIA-Glc, EIII-Glc, Glucose-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF2_LISMF
Sequence: MELAEIRNELEKTAQQIKDFRGSLDLDSMEVRIAELEDQMLDPNFWNDQQAAQKVINESNGYKETYQAFHALEEEQESMEISLELLKEEADEDLQEELEKDIKAYMATISEFELKLMLSDPYDKNNAILELHPGAGGTESQDWGSMLLRMYQRWSEKKGFKVEMLDYQAGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSVDVMPELDDDIEIEVRTEDLKIDTYRATGAGGQHINTTDSAVRMTHIPSGIVVTCQSERSQLKNREQAMKMLKTKLYQKEQEEKERELAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNYETGNIQAVMDGDLDEFINAYLRSRIG
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_ALIB4
Sequence: MYLIVGLGNIGEKYQYTRHNVGFLVIDEMAKNLQTSNVNNSNFQSTLLKSGYNLFAKPTTYMNNSGVAVHSIKEYYKIDLENIIVIHDDLDLPFGTVKFKIGGGHGGHNGLKSLDSHIGKDYIRVRIGIGKPQNKDDVANFVLSDFSKEELNKLEDIIKHTINAIEALKTADIDEVKSKFTLK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_LEPBP
Sequence: MNRLFLVLIFLYKKLLSPFLPPSCRFTPSCSEYAKQAFETYPWYKAFVLSVVRISKCHPYHEGGHDPLPKSYNKS
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TDGF3_HUMAN
Sequence: MDCRKMVRFSYSVIWIMAISKAFELGLVAGLGHQEFARPSRGDLAFRDDSIWPQEEPAIRPRSSQRVLPMGIQHSKELNRTCCLNGGTCMLESFCACPPSFYGRNCEHDVRKENCGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLAGICLSIQSYY
What is the function of this protein?
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.  Activates the Nodal-dependent signaling pathway.
What are the official names of this protein?
Putative teratocarcinoma-derived growth factor 3, Cripto-3 growth factor, Epidermal growth factor-like cripto protein CR3, Teratocarcinoma-derived growth factor 1 pseudogene 3.
What is the protein family that this protein belongs to?
Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
What are the subcellular locations of this protein?
Cell membrane.
Protein: NUOD_NITWN
Sequence: MTEALGTVTPGMRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEQKTYLQAIPYFDRLDYVAPMNQEHAFCLAAERLLGIAVPRRGQLIRVLYCEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMMFYERASGSRMHAAYFRIGGVHQDLPPRLIDDIEAWCDPFLQVVADLDRLLTANRIFKQRNVDIGVVTLEQAWEWGFSGVMVRGSGAAWDLRKAQPYECYAEMDFDIPIGKNGDCYDRYLIRMEEMRQSVRIMKQCIAKLRAPDGQGPVAVEDNKIFPPRRGEMKRSMEALIHHFKLYTEGFHVPAGEIYAAVEAPKGEFGVYLVSDGSNKPYKCKIRAPGFAHLQAMDFICRGHLLADVSAILGSLDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS16_THERP
Sequence: MIKLRLRRMGKKRQPHYRIVAAEARWPRDGRFIEVIGYYNPRTDPYTLEVNVERARWWLEHGAQPTDTVRALLVRAGVLPPRQQNEAKRETAETAQPEA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: FABG_PSEAE
Sequence: MSLQGKVALVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLVLDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEWFDVVNTNLNSLYRLSKAVLRGMTKARWGRIINIGSVVGAMGNAGQTNYAAAKAGLEGFTRALAREVGSRAITVNAVAPGFIDTDMTRELPEAQREALLGQIPLGRLGQAEEIAKVVGFLASDGAAYVTGATVPVNGGMYMS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
What are the official names of this protein?
3-oxoacyl-[acyl-carrier-protein] reductase FabG, 3-ketoacyl-acyl carrier protein reductase, Beta-Ketoacyl-acyl carrier protein reductase, Beta-ketoacyl-ACP reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RL13_SALNS
Sequence: MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMFRKLKVYAGNEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PLYD_EMENI
Sequence: MFFKQLAVLSFATSALAAHGVRNPGTNSLNFNRIDKRFTFPIPESQGSQTFEATYTISGNETFDGGMKTYGRGVDCSGQAEGGDSDAVFIVKDGGTLKNAIIGADQIEGVHCEGSCTIENVWWEAVCEDALSLKTGDGPFTVIGGGAQNADDKVIQHNGGGTVSISGFTAYNFGKLYRSCGNCDEMYERHVTLESVTAVSGSASLVGINSNYGDTATIKSDTCVTDVDTVCTEYEGTDNNDEEPQEISTGPSNACQYTDPLPSC
What is the function of this protein?
Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.  Favors pectate, the anion, over pectin, the methyl ester (By similarity).
What are the official names of this protein?
Probable pectate lyase D.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRMA_XANCP
Sequence: MPFLELTLPCTRATQPRFENALEDVGALAVTMLDAHAGTINERAILEPGVGEVRLWEETELTALFDGDSDPLMLLAALEAFDPSLDTRHATFRSVEDSAWERAWIDQFKPMRFGARTFIVPWNQDLPEEANTPDAAVVRLDPGLAFGSGTHQTTALCLRWLDALAGEGQLQGCSVLDFGCGSGILALAALKLGAANAVGVDYDPQALLATAENAERNAMEAQMQVYLPQDEPVQTYPVVLANILATALDALAETLAARVAPGGRIALSGIMQGQEQDLVQRYTPWFEHLHCEYDAEWVRIDGVRRH
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMT_MYCTO
Sequence: MDQFPIMGVPDGGDTAWMLVSSALVLLMTPGLAFFYGGMVRSKSVLNMIMMSISAMGVVTVLWALYGYSIAFGDDVGNIAGNPSQYWGLKGLIGVNAVAADPSTQTAAVNIPLAGTLPATVFVAFQLMFAIITVALISGAVADRLKFGAWLLFAGLWATFVYFPVAHWVFAFDGFAAEHGGWIANKLHAIDFAGGTAVHINAGVAALMLAIVLGKRRGWPATLFRPHNLPFVMLGAALLWFGWYGFNAGSATTANGVAGATFVTTTIATAAAMLGWLLTERVRDGKATTLGAASGIVAGLVAITPSCSSVNVLGALAVGVSAGVLCALAVGLKFKLGFDDSLDVVGVHLVGGLVGTLLVGLLAAPEAPAINGVAGVSKGLFYGGGFAQLERQALGACSVLVYSGIITLILALILKFTIGLRLDAEQESTGIDEAEHAESGYDFAVASGSVLPPRVTVEDSRNGIQERIGQKVEAEPK
What is the function of this protein?
Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)).
What are the official names of this protein?
Ammonium transporter, Ammonia channel, Ammonium channel.
What is the protein family that this protein belongs to?
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLD_METFK
Sequence: MTAQIINGKAIAEATLSETKSLIDKRLEKGLRAPTLAVILLGSDPASTIYVRNKRLACDKTGIRSLAYDLPDTTSEAELLALIKQLNQDDAVDGILVQSPLPAHIEEKKIIETISATKDVDGFHPYNIGRLAVRQPTLRSCTPYGVIKLLQSTGVRLLGLDAVVVGVSNHVGRPMALELLLAGCTVTSCHRHTKDLQASIARADIVVAAVGKPHLIKGEWIKPGAIVIDIGINRLADGSLCGDVEFDIAKTRAAWITPVPGGVGPMTVATLMQNTLTALELGESDQAPA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: CCSA_ILLOL
Sequence: MIFVILEHILTHISFSIIAIVITTHLMTLLVHEIVGLCDSSEKGMIATFFCITGLLVTRWIYSGHFPLNDLYESLMFLSWSFSLILMVPYFKNHKNHFSTITAPSAICTQSFATSGLSTEIHQSEILVPALQSHWLMMHVSMMLLSYAALLCGSLLSIALLVITFRKNIDMIGFTNHLLIWPFSFGEIKYLNEKRSLLKNTSFLLFRNYHRYQLTQRLDHWSYRVIGLGFTFSTIGILSGAVWANEAWGSYWNWDPKETWAFITWTISAIYSHTRTNKSLQGMNSAIVASMGFLIIWICYFGVNLLGIGLHSYGSFT
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: AT8A1_HUMAN
Sequence: MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW
What is the function of this protein?
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931).  Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules.  In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931).  The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane (By similarity).  Acts as aminophospholipid translocase at the plasma membrane in neuronal cells (By similarity).
What are the official names of this protein?
Phospholipid-transporting ATPase IA, ATPase class I type 8A member 1, Chromaffin granule ATPase II, P4-ATPase flippase complex alpha subunit ATP8A1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:20947505). In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the plasma membrane (PubMed:20947505). Localizes to plasma membranes of red blood cells (By similarity).
Protein: SEPF_STRPJ
Sequence: MSLKDRFDRFIDYFTEDEDSSLPYEKRDEPVFTPVNSSQEPALPMNQPSQSAGTKENNITRLHARQQELANQSQRATDKVIIDVRYPRKYEDATEIVDLLAGNESILIDFQYMTEVQARRCLDYLDGACHVLAGNLKKVASTMYLLTPVNVIVNVEDIRLPDEDQQGEFGFDMKRNRVR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: ZIC1_HUMAN
Sequence: MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGMGAFKLNPSSHELASAGQTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLFRNRGFGDAAAAASAQHSLFAASAGGFGGPHGHTDAAGHLLFPGLHEQAAGHASPNVVNGQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPSTDNPTTSSLSPSSSAVHHTAGHSALSSNFNEWYV
What is the function of this protein?
Acts as a transcriptional activator.  Involved in neurogenesis.  Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum.  Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN).  Plays a role in the regulation of MF axon pathway choice.  Promotes MF migration towards ipsilaterally-located cerebellar territories.  May have a role in shear flow mechanotransduction in osteocytes.  Retains nuclear GLI1 and GLI3 in the cytoplasm.  Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
What are the official names of this protein?
Zinc finger protein ZIC 1, Zinc finger protein 201, Zinc finger protein of the cerebellum 1.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.
Protein: RL4_BURP0
Sequence: MELKLLNSNGQEGAVVNASDVVFGRDYNEALIHQVVVAYQANARQGNRAQKDREQVKHTTKKPWRQKGTGRARAGMSSSPLWRGGGRIFPNSPDENFSHKVNKKMHRAGLCSIFSQLAREGRLSVVEDIVLEAPKTKLLADKFKAMGLDSVLVITDTVDENLYLASRNLPHVAVVEPRYADPLSLIYFKKVLVTKAAVAQIEELLS
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NTPTH_PYRAE
Sequence: MTWRERAELRIGISGMPGVGKTTLVLKIAELARSRVKVCGFVTVEVREGGTRIGFDVVDLANGRRMALARVGRGEPSVGKYVVNLEACNVISEALRRECDLKIIDEIGAMEFKCKNFGEDLQTALHTSPRVIATVHRNYIDIAKKLGLEIIWLTRENWGLVFRQLLIQLGLTQ
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: VPR_HV1YB
Sequence: MERAPEDAGPQREPYNEWALELLEELKNEAVRHFPRIWLHGLGQHIYNTYGDTWEGVEAIIRILQQLLFIHYRIGCQHSRIGITPQRRRNGASRS
What is the function of this protein?
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus.  This function is crucial for viral infection of non-dividing macrophages.  May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: ATPB_YERPN
Sequence: MATGKIIQVIGAVVDVEFPQDAVPKVYNALEVEGTTEKLVLEVQQQLGGGVVRCIAMGSSDGLSRGLKVTNLEHPIEVPVGKATLGRIMNVLGEPIDMKGPIGEEERWAIHREAPSYEELASSQDLLETGIKVMDLICPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMTDSNVLDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLLFIDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIASLGIYPAVDPLDSTSRQLDPLVVGQEHYDVARGVQSILQRYQELKDIIAILGMDELSEDDKLVVSRARKIQRFLSQPFFVAEVFTGSPGKFVSLKDTIRGFKGIMNGDYDHLPEQAFYMVGTIEEAVEKAKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YCIZ_ECOLI
Sequence: MSEFDAQRVAERIDIVLDILVAGDYHSAIHNLEILKAELLRQVAESTPDIPKAPWEI
What are the official names of this protein?
UPF0509 protein YciZ.
What is the protein family that this protein belongs to?
Belongs to the UPF0509 family.
Protein: RS12_EIKCO
Sequence: ACPQKRGVCTRVYTTTPKKPNSALRKVCKVRLTNGFEVISYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHTVRGTLDTAGVKDRKQARSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: SLYB_SHIFL
Sequence: MIKRVLVVSMVGLSLVGCVNNDTLSGDVYTASEAKQVQNVSYGTIVNVRPVQIQGGDDSNVIGAIGGAVLGGFLGNTVGGGTGRSLATAAGAVAGGVAGQGVQSAMNKTQGVELEIRKDDGNTIMVVQKQGNTRFSPGQRVVLASNGSQVTVSPR
What are the official names of this protein?
Outer membrane lipoprotein SlyB.
What is the protein family that this protein belongs to?
Belongs to the Pcp/SlyB lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: Y1625_DICDI
Sequence: MGCVVSKSDDIKNENESRQRNQASSSQQPSSSQTPSKQIGIAAKDSEEQPQEVSYSQMRELDNDFFKDIIDRTAQKFIDVSMVGPDGKDSFLDREKDYSAQIKDSKLLKPTSLTSLPRLSQQCQMSNLQNLLSQPTTFDNELMSKYTSSISENLNGIHIKECGELVVFFGNSLK
What are the official names of this protein?
Uncharacterized protein DDB_G0292160.
Protein: PG165_VACCW
Sequence: MEIFPVFGISKISNFIANNDCRYYIDTEHQKIISDEINRQMDETVLLTNILSVEVVNDNEMYHLIPHRLSTIILCISSVGGCVISIDNDINDKNILTFPIDHAVIISPLSKCVVVSKGPTTILVVKADIPSKRLVTSFTNDILYVNNLSLINYLPLSVFIIRRVTDYLDRHICDQIFANNKWYSIITIDDKQYPIPSNCIGMSSAKYINSSIEQDTLIHVCNLEHPFDLVYKKMQSYNSVPIKEQILYGRIDNINMSISISVD
What are the official names of this protein?
Protein OPG165.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG165 family.