PharMolix/UniProtQA huggingface dataset:
Protein: FABZ_FRATW
Sequence: MSQFNQNNKQIDVMGIRKILPHRYPFALLDKIVDWSVEDRTIVAQKNVTINEDFFNGHFPDFPVMPGVLIVEAMAQATAILGELMAETLFAHVVEKAGGGRRTFMLAGIDKVRVKRPVVPGDVLVIESRMVKQKNIICTAESVAKVDGQIVCSAELMAAYKDY
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSW_MESVI
Sequence: MIRRFVSICIQLIEDLLIGGWNSIWYYLFPIMHPRCANWWSVARWLQWLTFLWLSIGLIVLCSASYPSAQFEFNDGLYYVKRQLLWTILGILEFNLLTRLLIKDILKISSLGIIFSFLCLLLTFPMGISVNGASRWIAIGPILLQPSEIIKPFLILQSSYIFSQWDNISYSKKIFWVILFISIIGSILIQPNLSTASLCGAIIWLVALTAGIHWFYLNSILSIGAVTALISLGSQEYQRQRIISFLNPWANPTSIGYQLVQSLLAVGSGRLTGSGISCSYQKLFYLPIQYTDFIFSVFSEEFGLLGAFLFISLLIIYFSLGMIVVLSNKSKVNRLLALGCIMVLVGQSLINIGVSVGILPTTGLPLPFFSYGGNSILATFFVSAILIRVAIETEIDNRINIFSLLNKQSIFYWFK
What is the function of this protein?
Could play a role in chloroplast division/peptidoglycan biosynthesis.
What are the official names of this protein?
Putative peptidoglycan glycosyltransferase FtsW, PGT, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: AACS_XENTR
Sequence: MSDKGELMEEIMEAKVMWYPDSKKITQMDQFRNRVNRNLGLRLANYNELYQWSVEFYPEFWAEFWDFSGIVYSKTYDEVIDRSKGIADVPEWFKGSRLNYAENLLKHKENDKIALYSAREGKENIEKVTFAELRRDVALFAAAMRKMGIKTGDRVAGYLPNCIQTVEAMLAAASIGAIWSATSPDFGVNGVLDRFSQIQPKLILSVESVIYNGKEHCHLEKLQHVVKGLPDLKKVVVIPYVLPKEKIDISKIPNSMFLDEFLATGKVGDQSPQLEFEQLPFNHPLYIMYSSGTTGAPKCMVHSAGGTLIKHLTEHILHGSTTSSDVIMYYTTAGWMMWNWLITAVATGASLVLYDGSPLVPSLNVLWDLVDRLGITILGTGAKWLAVLEDKGLKPCNTHSLQTLHTILSTGSPLKPQSYEYVYKHIKSNVLLGSVSGGTDIIACFMGQNVSVPVYKGEIQARHLGMAIEAWNEEGEAVLGESGELVCLKPLPSQPTHFWNDENGSKYQKAYFAKFPGVWAHGDYCKINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVEAFVEVSDSLCVPQYNKDGDERVILFLKMADKFEFSKELLKRIKDAIRVALSARHVPALILETKDIPYTISGKKVEVAVKQVIAGKEVPHRGAFSNPQSLDLYRNIPELQNF
What is the function of this protein?
Activates acetoacetate to acetoacetyl-CoA.
What are the official names of this protein?
Acetoacetyl-CoA synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: NDKA2_XENLA
Sequence: MAANKERTFIAIKPDGVQRGLMGDIIKRFEQKGFRLVAMKFLQASQDLLRQHYIDLKDRPFYPGLVEYMNSGPVLAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDLCIQVGRNIIHGSDSVDSANKEIALWFKDEELVEYKSCAYEWVYEN
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase A2, NDK A2, NDP kinase A2, NM23/nucleoside diphosphate kinase A2.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_CUTAK
Sequence: MRVVIQRATSAEVVVEGRTVGSLTTPGLVVLVGVTGTDTATTAEKLAEKVWGLRILSEEKSASDLNAPLLVVSQFTLYASTRKGRRPSWSAAAPGPVSEPLVDHFVTHLRSLGAHVETGIFGADMKVGLVNDGPMTILIDTDDWH
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAG_MYCGE
Sequence: MVNKSNSLDELLKQIKITEIIQHYGVKIQTKGNSLLALCPFHDDKNPSMSISSSKNIFKCWACNAAGNGIAFIQKHDQLDWKTALKKAIEICGIKLENWNSNLLTKVDPKQKRYWEINNALITYYQTRLKRETNPNGMNYLVEKRKLNKTLIEQFQLGLAFHNEDKYLCESMERYPFINPKIKPSELYLFSKTNQQGLGFFDFNTKKATFQNQIMIPIHDFNGNPVGFSARSVDNINKLKYKNSADHEFFKKGELLFNFHRLNKNLNQLFIVEGYFDVFTLTNSKFEAVALMGLALNDVQIKAIKAHFKELQTLVLALDNDASGQNAVFSLIEKLNNNNFIVEIVQWEHNYKDWDELYLNKGSEQVILQANKRQNLIEYLVSFFKKQQLDQRVITNKIIAFLTKNQTILNDHSFLIFLIKNLVKLLEYSDEKTLYETVLKHKEKLVSKFDNNRFYINTSGHAQPPQELQKTTAALVQTAFEEAVNELWKPEIFAFALIDKRFLVELKQSHLDEVFKECNFNLFDVELFIEKARIYWSENQTANWVGFESVLDQNYLLNNKARLLEIKDIFLDELTCYQANDFQNYLKTFQTLLKQQKQRLKNLKLTL
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the DnaG primase family.
Protein: PXPA_STRGG
Sequence: MMDLNADLGEGFGNWTLTDDDALLACVTSANVACGFHAGDASVMRRVCDAAAAGGVRIGAQVSYRDLAGFGRRSMDVPPAELTAEIAYQIGALRVFAEAAGATVSYVKPHGALYNRVVWDDDQAAAVVAGVRLAGGAPAVLGLPGSRLLAHAAEAGLPAVQEAFADRAYTPQGTLVPRGEPGAVVHDPDDVVRRSVGMAVERAVTGADGSRIPVAARSLCVHGDTPGAAALARRVRAALEEAGVEVRAFA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: TRPF_METMP
Sequence: MFIKICGIKTPEELRIVENYGNATGVILECASKRRIGFETAKNLVNLANIPVFAVSTASDVSVWENIIEFTGTNYLQMHSDIDQKAIDFIKNEYGCFIMKSFKIPETSTSPEIDAEKIISEIESYEVDRILLDTGKGCGQTHDHRVSQIIAKKFDIVLAGGLDPDNVLNIVKYVKPFGIDVSSGVENNNSKDEELIKRFCENVKLGENYEM
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: DER_PROMH
Sequence: MIPVIALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAELDGEEFIIIDTGGIDGAEEGVETHMASQSLQAIQEADIVLFLVDARAGLMPADQGIAKHLRGVEKKTYLVANKTDGIDIDTALADFYSLGLGEIFPIAASHGRGVSQLIEQALLPIVGKFVEEEKELTEEEENAAYWAALEAEQKEQEEEEEEDDFDPTTLPVKLAIVGRPNVGKSTLTNRMLGEERVVVYDMPGTTRDSIYIPMERDGKEYILIDTAGVRKRGKVKETVEKFSVIKTLQAIEDCNVALLVIDAREGISDQDLSLLGYILNSGRSLVIAVNKWDGMTQEDREQVKDMLDLKLGFVDFARVHFISALHGSGVGNLFESIQEAYTCATRRVGTSMLTRIMKMAEDDHQPPLIRGRRVKMKYAHAGGYNPPVVVIHGNQVSDLPDSYKRYLMNYFRRTLQVMGTPIRIQFKEGENPYADKKNKLTASQIRKRKRLMAHLKKSK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: HIFA2_HAEIF
Sequence: MKKTLLGSLILLAFAGNVQADINTETSGKVTFFGKVVENTCKVKTEHKNLSVVLNDVGKNSLSTKVNTAMPTPFTITLQNCDPTTANGTANKANKVGLYFYSWKNVDKENNFTLKNEQTTADYATNVNIQLMESNGTKAISVVGKETEDFMHTNNNGVALNQTHPNNAHISGSTQLTTGTNELPLHFIAQYYATNKATAGKVQSSVDFQIAYE
What is the function of this protein?
Mediates adherence to oropharyngeal epithelial cells.  Helps the airway colonization process.
What are the official names of this protein?
Major fimbrial subunit, Major pilin.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: RL5_SYNS9
Sequence: MSLKKRYRETIQPKLLKDLSLTNIHEVPKVMKVTINRGLGEAATNAKSLEASVKELAQITGQKVVVTRAKKAIAGFKIRQGMPIGCAVTLRGDRMYAFLERLINLALPRIRDFRGVSAKSFDGRGNYTLGVREQIIFPEISFDKIDAIRGMDITIVTTARSDEEGRALLSEMGMPFQSN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ATPF_OENAR
Sequence: MKNVTDSFVSLVHWPSAGSFGFNTDILATNPINLSVVLGVLIFFGKGVLSDLLDNRKQRILNTIRNSEELREGAIEQLEKARARLQDVQIEAEGYRAYGYFGIDEQRHESINSTYKTLEQLENNKNESIHFEQQRAINQVRQQIFQQALQGALGTLNSCLNNELHLRTISANIVLFGSMKELTD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y2558_MYCTO
Sequence: MPGSAGWRKVFGGTGGATGALPRHGRGSIVYARSTTIEAQPLSVDIGIAHVRDVVMPALQEIDGCVGVSLLVDRQSGRCIATSAWETLEAMRASVERVAPIRDRAALMFAGSARVEEWDIALLHRDHPSHEGACVRATWLKVVPDQLGRSLEFYRTSVLPELESLDGFCSASLMVDHPACRRAVSCSTFDSMDAMARNRDRASELRSRRVRELGAEVLDVAEFELAIAHLRVPELV
What are the official names of this protein?
Uncharacterized protein MT2635.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv2557.
Protein: AROK_FRATM
Sequence: MIRTKNIFLIGPVGAGKSTIGKQLAKQLKLEFIDSDDVIEKKCGVDINWIFDLEGEEGFRKREREVIAEILAEKQNIVLATGGGAILDPETRSLLSSRGKVVYLEATIEQQLERTSKDTKRPLLRVDDKRPVLEQLMAEREPLYRSIADVVVETNGATVKNIVNKISTFLVEETIL
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DH12B_DANRE
Sequence: MEPFADALFWVGAVTVLWLSVSSLWSLINGIRVWILGNGNLMRASSLGKWAVVTGATDGIGKAYAEELARRGFAIVLISRTQEKLDEVSKAIESKYKVETKTISADFGSVDIYPKIESGLAGLEIGVLVNNVGVSYSYPEFFLNIPDVDSFINNMININIMSVCQMTRLVLPRMVDRSKGVILNVASASGMYPVPLLTLYSSTKAFVDFFSRGLDAEYKSKGIIIQSVLPFYVTTKLSKIRKPTLDIPTPERYVKAQLSTIGLQTQSNGYLPHAIMGWVTASLLPAKLLNKYVMGMGLSQRARYLKKQKQG
What is the function of this protein?
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle.  This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle.  This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation.  Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.  May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
What are the official names of this protein?
Very-long-chain 3-oxoacyl-CoA reductase-B, 17-beta-hydroxysteroid dehydrogenase 12-B, 17-beta-HSD 12-B, zf3.3, zfHSD17B12B, 3-ketoacyl-CoA reductase, KAR, Estradiol 17-beta-dehydrogenase 12-B.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: AROA_BLOFL
Sequence: MENFITLNPIKKINGTIYLPGSKSISNRALLLAAQSVGATRLINLLDSDDTRYMLAALLQLGVKYKLSTDHKICEIKGVGGSLQSKNTQTTLFLGNAGTAIRPLIAALSIKSHNIVLTGDMRMKERPIFHLVDTLRQGGGRIEYIERDHHLPVKLYGGYCGGNIVIKGDISSQFLSAVLMMTPLASKNTYIEVIGSLVSKPYIDITLSVMRAFGICVQHDKDYKFFYCEGNRIYKAPQEYVIEGDASSASYFLAAAAIKGGTIRVLGVGKNSKQGDIKFANILERMGSIITWGDNYIECSKGIMLKSIDIDVNDIPDAAMTLAVIALFTTNNLPMILRNIYNWRVKESDRLHAMATELRKVGAIVSEGYDYLHIVPPVQIQSAFINTYNDHRIAMCFALVALSNVSVTINNPKCVCKTFPDFFDRFLSVGNNL
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEG_CYCMS
Sequence: MSTIEKHTQIVKKTASKLGFDYCGIAEATFLEEEAPKLENWLNKNYHGKMAYMANHFDKRLDPRKLVEGAKSVVSLMFNYYPQQNLDESRNALKIAKYAYGEDYHFVIKDKLKEFLKCLKEEIGEVHGRVFVDSAPVMERQWAVKAGLGWKGKNSLLLNKSSGSFFFLAELIIDLPLIYDNPSDKDYCGTCTRCVDACPTDAILQDNLIDGSKCISYLTIELKEAIPDDFKGKMENWVFGCDICQDVCPWNRFSKPHKEEAFLPHADLEKSAWEEMTKETFNKVFKRSALKRTKWEGFQRNIHFVKNEAS
What is the function of this protein?
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
What are the official names of this protein?
Epoxyqueuosine reductase, Queuosine biosynthesis protein QueG.
What is the protein family that this protein belongs to?
Belongs to the QueG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC11_AJEDR
Sequence: MLSSLSPYMANPRQTFTQVLNFALVLSTAFMLWKGLSVYTNSASPIVVVLSGSMEPAFQRGDLLFLWNRSPRVDVGEIVVYNVRGKDIPIVHRVMRTFPDVPGKDKTKKGGKQGVEASPSSLESQKLLTKGDNNLSDDTELYARGQDYLDRKEDIVGSVRGYIPAVGYVTIMLSEHPWLKSVLLGFMGLMVILQRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: CCMA_RICFE
Sequence: MLSLHQLQFNIEQRNLFNLNITFLPSSITYIKGANGSGKSSLLRMISGIMQPNSGNIYYKNNNINNIPKPYCTYIGHNLGLKLEMTVLENLKFWSEIYNSSETLYAAIHYFKLQDLLDEKCYSLSSGMQKVVAAARLIACQSDLWLLDEVETNLSKENRDLLNNLIVMKANSGGIVLLSSHLESSIKSAQILQLV
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL15_THEP1
Sequence: MRLEDLRPTPGAMKKRKRVGRGPGSGHGKTSGRGHKGQKARGSGKVHIWFEGGQTPLHRRLPKRGFNNINKKVYAVVNVKVLEERFEANEEVTPEKLIERKIIKDLKDGIKILGDGELTKPLVVKAHAFSKSAVEKIESAGGKAEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: LAP_RFVKA
Sequence: MSTIVDMVDVSLVDKCCWICKESCDVVRNYCKCRGDNKIVHKECLEEWINTDTVKNKSCAICETPYNVKQQYKKLTKWRCYRRDCHDSLLVNLPLCLIVGGISTYTLVSVEIIKLMESEETSELTKVFLVTSFLGPFIVTVLSALRTCIDCRTYFLTTRKRNTIHTLQELEDDDDDDDDDDDDDDEEYADAVEEIIIGPSN
What is the function of this protein?
E3 ubiquitin-protein ligase which promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.  Binds target molecules through transmembrane interaction.  The result of this ubiquitination is the enhancement of the endocytosis of the target chain and the delivery to the lysosome, where it is proteolytically destroyed.
What are the official names of this protein?
E3 ubiquitin-protein ligase LAP, Leukemia associated protein, LAP, RING-type E3 ubiquitin transferase LAP.
What is the protein family that this protein belongs to?
Belongs to the poxviridae LAP protein family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network membrane. Host early endosome membrane.
Protein: DNAS1_OREMO
Sequence: MQTYRSRMHLVCSLGLFLTLLHLSNSLLLGAFNIKSFGDTKASNATLMNIITKIVKRYDVILIQEVRDSDLSATQTLMNYVNKDSPQYKYIVSEPLGASTYKERYLFLYREALVSVVKSYTYDDGPEETGQDTFSREPFVVMFSSKNTAVRDFTLIPQHTSPDLAVRELNALYDVVLDVRARWNTNDIVLLGDFNAGCSYVSGSAWQQIRIFTDKTFHWLITDAADTTVSQTVCPYDRIVVTTDMMRGVVQNSAKVYNYMTDLNLKQDLALAVSDHFPVEVKLS
What is the function of this protein?
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:9395327).  Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity).  Among other functions, seems to be involved in cell death by apoptosis (By similarity).  Binds specifically to G-actin and blocks actin polymerization.  Preferentially attacks double-stranded DNA and produces oligonucleotides with 5'-phospho and 3'-hydroxy termini (PubMed:9395327).
What are the official names of this protein?
Deoxyribonuclease-1, Deoxyribonuclease I, DNase I.
What is the protein family that this protein belongs to?
Belongs to the DNase I family.
What are the subcellular locations of this protein?
Secreted. Zymogen granule. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.
Protein: GRPE_BIFAA
Sequence: MSDFNKDEYLNDLPDMDDLSGQAAPAAASADSAAAAAGATQEGAAQPAAAQSQENGDSAAADGADKAGAADGKADDTLTPLGQAKKEAAEYLEALQRERAEFINFRNRAQKEQERFRQHGIIDVLTALLPALDDIDRIREHSEMDDSFKAVANKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKPDPNAEKETVDTVVEAGYRIGDRVIRAARVVVASPQN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y630_PSYWF
Sequence: MEKLLKKLPFYDHTWFNFLRFLIGNFIKDDGQQKAASLTYTTLLSIVPILTVLLMILSSVPALESVREQISNIIYSNLLPQSGLQVSEYINNFAEKSSNLTAIGALALFVTTIMTLTTIERAFNQIWRVEDRSGGIKSIVRYWTIITLGPLVLGTAFLVSSAVQSLSFLNQQVAGYGIDWGFWVQVVSFAVTIAGFIGMYWFIPKAKVPLKNAAIAGVFVAVTFELLKYSFGIIMSNFTSYEAIYGAFAALPIFLLWIYLSWNLILLGVEISYTLTIFATSEVYPRHPLLSLLDMLNLVHDRYQQGKDTSEEDLRSVLGRKELPKWFTYLNYLKDAHLITETDEGNYVLKKDLDNITLWEFYRTLPYPLPIKDELDEVCANARTPWLSLLVQRFVQTEKHARQELDIPLAKIFAHSLPREKVEVSHSVFSAQDADAKRTTSQSTTAEGGRQSAAEDGKFDAQPFDPNADVLPDSDSKEATNPPDADIKAAAAKGTVNSAQHSKHTETAKQEHKKTGLLGLFSHDKDAPIITEDDNPNK
What are the official names of this protein?
UPF0761 membrane protein PsycPRwf_0630.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: METK_WIGBR
Sequence: MNQYLFTSESVSEGHPDKIADQISDTILDAILTQDKKARVACETYIKTGMVLVGGEVNSYAKIDIEELIRNTIKDIGYINSNMGFDANSCAILNNISKQSKDIEKGLNQLDPYMQGAGDQGIIFGYATNETETFMPAPITYANKLMIRQSEVRKKNILPWLRPDAKSQITFIYENKKIVGIDTVIISSQHSEEINLSDLREGIMEEIIQPILPKKWISNKTKYFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGSFSGKDPSKVDRSAAYALRYVAKNIVASGLADRCEIQISYAIGVSNPISIFIETFGTQKISNKKLINLIHENFDLRPHGLIVMLDLLKPIYRETAVYGHFSKIHFPWEKIDKANILRDSSGIKI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPPC_MYCTU
Sequence: MTSTLHRTPLATAGLALVVALGGCGGGGGDSRETPPYVPKATTVDATTPAPAAEPLTIASPMFADGAPIPVQFSCKGANVAPPLTWSSPAGAAELALVVDDPDAVGGLYVHWIVTGIAPGSGSTADGQTPAGGHSVPNSGGRQGYFGPCPPAGTGTHHYRFTLYHLPVALQLPPGATGVQAAQAIAQAASGQARLVGTFEG
What is the function of this protein?
Probably involved in bacterial recognition and uptake by its host (human) (PubMed:25041568).
What are the official names of this protein?
Putative lipoprotein LppC, UPF0098 protein Rv1911c.
What is the protein family that this protein belongs to?
Belongs to the UPF0098 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cell surface. Note=Immunoelectron microscopy indicates this protein is displaced from the cell surface (PubMed:25041568).
Protein: TSAD_BURM1
Sequence: MLVLGIESSCDETGLALYDTQRGLLAHALHSQIAMHRDYGGVVPELASRDHIRRALPLLEEVIAKSGARREDIDAIAFTQGPGLAGALLVGASIANALALAWNKPTVGIHHLEGHLLSPLLVAEPPPFPFVALLVSGGHTQLMRVTDVGVYETLGETLDDAAGEAFDKTAKLIGLGYPGGPEVSKLAETGTPGAVVLPRPMLHSGDLDFSFSGLKTAVLTQMKKFEAAQLSGDALARAKADLARGFVDAAVDVLVAKSLAALKKTKLKRLVVAGGVGANRQLRAALSAAAAKRGFDVHYPDLALCTDNGAMIALAGALRLARWPEQANVDYAFTVKPRWDLASLAR
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3S11_MICTC
Sequence: MICYNQQSSEPPTTKTCSEGQCYKKTWSDHRGTIIERGCACPNVKPGVKISCCSSDK
What is the function of this protein?
Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site (By similarity).  Binds to and inhibits the endogenous nicotinic acetylcholine receptors (nAChR) (By similarity).  This neurotoxin is lethal to mice by intraperitoneal or intravenous injection (PubMed:31211957).
What are the official names of this protein?
Three-finger toxin Tschuditoxin-I.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.