PharMolix/UniProtQA huggingface dataset:
Protein: YQGF_STRPQ
Sequence: MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIKIDEEKAEFGFTRLEELVKQYQVEQFVIGLPKNMNNTNGPRVDASITYGNHIEHLFGLPVHYQDERLTTVEAERMLIEQADISRGKRKKVIDKLAAQLILQNYLNRNF
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNPH_BOVIN
Sequence: MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
What is the function of this protein?
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity).  Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity).
What are the official names of this protein?
Purine nucleoside phosphorylase, PNP, Inosine phosphorylase, Inosine-guanosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAF_CYAPA
Sequence: MRKLFLLMFCLSGLILTTDIRPVRADVAGLIPCSQSDAFERRLKNTTQRLENRLKKYEPGSAPAEALQKQIDKTQQRFDKYRNSGLLCGADGLPHLITDGRWSHAGEFTIPGLLFLYIAGFIGWSGRSYLQAVAASDNSTEKEIIIDIPVALQSVSKGFVWPLAALQEFSSGKLTARDEEITISPR
What is the function of this protein?
Probably participates in efficiency of electron transfer from plastocyanin to P700 (or cytochrome c553 in algae and cyanobacteria).  This plastocyanin-docking protein contributes to the specific association of plastocyanin to PSI.
What are the official names of this protein?
Photosystem I reaction center subunit III, PSI-F.
What is the protein family that this protein belongs to?
Belongs to the PsaF family.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Multi-pass membrane protein. Note=The soluble domain is associated with the lumenal side of the thylakoid membrane.
Protein: RL17_PROMP
Sequence: MRHQLRVPLLSKPADQRKALLRALTTQLIREGRITTTKARAKALRNEAERMISLAKEGTLSARRRALGYIYDKKLVHSLFEKAQERYGERNGGYTRIVRTVARKGDNAQMAIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PSBE_THEVL
Sequence: MAGTTGERPFSDIITSVRYWVIHSITIPALFIAGWLFVSTGLAYDVFGTPRPDSYYAQEQRSIPLVTDRFEAKQQVETFLEQLK
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PSAE_PORUM
Sequence: MERGSKVKILRKESYWYQEIGTVAAMDKSGIKYPVLVRFEKVNYNNVNTNSFADNELIDLGK
What is the function of this protein?
Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.
What are the official names of this protein?
Photosystem I reaction center subunit IV, PSI-E.
What is the protein family that this protein belongs to?
Belongs to the PsaE family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: Y4117_ARATH
Sequence: MASSSSNSWRYDVFPSFRGEDVRNNFLSHLLKEFESKGIVTFRDDHIKRSHTIGHELRAAIRESKISVVLFSENYASSSWCLDELIEIMKCKEEQGLKVMPVFYKVDPSDIRKQTGKFGMSFLETCCGKTEERQHNWRRALTDAANILGDHPQNWDNEAYKITTISKDVLEKLNATPSRDFNDLVGMEAHIAKMESLLCLESQGVRIVGIWGPAGVGKTTIARALYNQYHENFNLSIFMENVRESYGEAGLDDYGLKLHLQQRFLSKLLDQKDLRVRHLGAIEERLKSQKVLIILDDVDNIEQLKALAKENQWFGNKSRIVVTTQNKQLLVSHDINHMYQVAYPSKQEALTIFCQHAFKQSSPSDDLKHLAIEFTTLAGHLPLALRVLGSFMRGKGKEEWEFSLPTLKSRLDGEVEKVLKVGYDGLHDHEKDLFLHIACIFSGQHENYLKQMIIANNDTYVSFGLQVLADKSLIQKFENGRIEMHSLLRQLGKEVVRKQSIYEPGKRQFLMNAKETCGVLSNNTGTGTVLGISLDMCEIKEELYISEKTFEEMRNLVYLKFYMSSPIDDKMKVKLQLPEEGLSYLPQLRLLHWDAYPLEFFPSSFRPECLVELNMSHSKLKKLWSGVQPLRNLRTMNLNSSRNLEILPNLMEATKLNRLDLGWCESLVELPSSIKNLQHLILLEMSCCKKLEIIPTNINLPSLEVLHFRYCTRLQTFPEISTNIRLLNLIGTAITEVPPSVKYWSKIDEICMERAKVKRLVHVPYVLEKLCLRENKELETIPRYLKYLPRLQMIDISYCINIISLPKLPGSVSALTAVNCESLQILHGHFRNKSIHLNFINCLKLGQRAQEKIHRSVYIHQSSYIADVLPGEHVPAYFSYRSTGSSIMIHSNKVDLSKFNRFKVCLVLGAGKRFEGCDIKFYKQFFCKPREYYVPKHLDSPLLKSDHLCMCEFELMPPHPPTEWELLHPNEFLEVSFESRGGLYKCEVKECGLQFLEPHETSEFRYLSPHLYLGGSWIGNSSSSIEEIIHVDQEESSSDSEEIIYADQEESSSGIEEIIHAEREGTNRRKSVMRWIKVGARKMGLSLECLKPWTR
What are the official names of this protein?
Putative disease resistance protein At4g11170.
Protein: RL13A_TETTS
Sequence: MFDKLVVIDAKGHLLGRLASYVAKELLSGQRIVVVRTEAINISGSLFRNRVKFSEFLNKWMNHNPRRGVQHFRAPSRIFWRAVRGMLPHKTPKGAAALERLKIFEGIPTPYDRVKKQVVVDALKVQRLRNSRPVCKLGDLSASVGWGKQTLIEKLEEKRRARAKTYHDKKVKQADARKKELAAPALKAIKDKLAQFGY
What are the official names of this protein?
60S ribosomal protein L13a.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: MIAB_BURM7
Sequence: MTKKVYVKTFGCQMNEYDSDKMVDVLNAAEGLEKTDTPEDADIILFNTCSVREKAQEKVFSDLGRVRELKEAKPDLLIGVGGCVASQEGASIVARAPYVDLVFGPQTLHRLPQMIDARRESGRAQVDITFPEIEKFDHLPPARVEGPSAFVSIMEGCSKYCSYCVVPYTRGDEVSRPLDDVLTEVAGLADQGVREVTLLGQNVNAYRGAIAAGSAEIADFATLIEYVADIPGIERIRYTTSHPKEFTQRLLDVYAKVPKLVDHLHLPVQHGSDRILMAMKRGYTVLEYKSVIRKLRAIRPNLSLSTDIIVGFPGETDADFDKTMALVHEMSYDTSFSFIYSPRPGTPAANLADDTPRELKLKRLQHLQATIEENVARISQSMLGKVERILVEGPSRKDPNELAGRTENNRVVNFPAPSAAHPRLIGQMIDVKINHAYPHSLRGELVLAHGDASAATH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANTA_HAEOF
Sequence: MIKLAILLLFTVAIVRCQGPFGPGCEEAGCPEGSACNIITDRCTCSGVRCRMHCPHGFQRSRYGCEFCKCRLEPMKATCDISECPEGMMCSRLTNKCDCKIDINCRKTCPNGLKRDKLGCEYCECRPKRKLIPRLS
What is the function of this protein?
This highly disulfide-bonded protein is a potent inhibitor of factor Xa.  May have therapeutic utility as an anticoagulant.  Also exhibits a strong metastatic activity.
What are the official names of this protein?
Antistasin, ATS, Blood coagulation factor Xa/proclotting enzyme inhibitor.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I15 (antistasin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: FENR_WOLPM
Sequence: MKTDIVIIGAGPVGIFTAFQAGMLDMRCHIIDVLDQAGGQCTALYPEKPIYDIPGYPVITAQKLIEQLMEQSSPFKPVYHLSQKVEKISNNEGESFTVITNIGTEVKCKAVIVAAGNGMFKPNRPPLSGILEYENKSVFYSVNKISDFQDKTIVIAGGGDSAADWTVELSKVAKKIYVIHRRKEFRCTPETRNKLESLEIDGKIELVVPYQLHELAGGNGQLSAVIVKNIASKEEKEISADFLLPFFGLSMNLGPINNWGIQLEHSRIVVDPATLKTSRDRIYAIGDIAIYSGKLKLILNGFAESAMACYDIYKVIHNSPVNFQYSTSKGIHGKEKLP
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: YACG_SALPA
Sequence: MSDVTVVNCPTCGKPVVWGEISPFRPFCSKRCQLIDLGEWAAEEKRIASSGDPSDSDDWSEER
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: NDK_ENCCU
Sequence: MERTFIMIKPDAIKRRLISRIIQRFEEKGLYLAASKCVIPKREVLETHYSHLSSMPFFSEMVEDMMSGMVLAMVWVGKDAVSIGRKLIGETNPQAASVGTIRGDYGVSTGKNIIHGSDCVENAEKEIKLWIGDDVQPVSFFDKEWIY
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, NDPK.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
Protein: DIC1_YEAST
Sequence: MSTNAKESAGKNIKYPWWYGGAAGIFATMVTHPLDLAKVRLQAAPMPKPTLFRMLESILANEGVVGLYSGLSAAVLRQCTYTTVRFGAYDLLKENVIPREQLTNMAYLLPCSMFSGAIGGLAGNFADVVNIRMQNDSALEAAKRRNYKNAIDGVYKIYRYEGGLKTLFTGWKPNMVRGILMTASQVVTYDVFKNYLVTKLDFDASKNYTHLTASLLAGLVATTVCSPADVMKTRIMNGSGDHQPALKILADAVRKEGPSFMFRGWLPSFTRLGPFTMLIFFAIEQLKKHRVGMPKEDK
What is the function of this protein?
Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate.  Required for growth on ethanol and acetate.
What are the official names of this protein?
Mitochondrial dicarboxylate transporter, DTP, Dicarboxylate carrier 1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RIMP_RHOP2
Sequence: MTDPIADSVAPDLLDEPRLVVEPGVAARFGAVAEPVLLAMGYRLVRIKVSAEAGCTVQIMAERPDGTMLIEDCEAVSKALSPVLDVTDPIEKAYRLEISSPGIDRPLVRRSDFARYSGHLVKIEMAVPHQGRKRYRGLLDGVEGDAIRIQREGVKDEDPLVLLPMHDIGDARLVLTDELIAESMRRGKQAERELKQSLGLAPPPPPHAKRSDPKKSNAPKPKPKPPVKAAAKPKPTNTKQHRLAAGRSRRGDTDLSEGD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBD_SYNWW
Sequence: MKIMVLGAGTMGAGIVQTAAQAGFEVVVRDIKQEFVDRGIAGIDKLLSKNVDKGRMTAEDKAAVMGRISGTVDMGAAADCDLVIEAALEVMDIKKAIFKELDSICKPECILASNTSALSVTEIAAATGRADKVIGMHFFNPVPAMKLVEVIRGASTSQATYDAIKDLSVKMGKSPVEINEAPGFVVNRLLIPMLNEGMYCLMEGVANAADIDTSMKFGAGHPMGPLALADMIGLDICLKIMETLYKEFGDPKYRPCPLLAKMVRANKLGRKTGEGFFAY
What is the function of this protein?
Involved in syntrophic growth of S. wolfei with butyrate, as part of the butyrate oxidation pathway.  Probably catalyzes the oxidation of 3-hydroxybutyryl-CoA to acetoacetyl-CoA.
What are the official names of this protein?
3-hydroxybutyryl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCXA_SYNS3
Sequence: MAFRNWIGAFGKANALDVNSDLDRGYEAALLIQSLELEYYGDRPIRPDLELSVPKSVQATVLRKFRVAINVCRASLDQLEYQRSQLDPQELRQLQLIESVVNRYSPKRVSTAPTMTRDPDPLPRSLLGVFDKVRRQLNPAGEATLVAGFRRRRDSTLISLKVLLLLILVPLLVQQVSRTYIISPAVDRFAPDLPFLSYPKPQLEEQAVEKLRVYKAEIEFDALLRGDTIPSQEELQQQLGKKASELKEEADAESTHAVKNVLADISATIAFVVVCLFSREELRVLRGFFDEAVYGLSDSAKAFAIILFTDIFVGFHSPEGWTVLLDGIANHFGFPARENFILLFIATFPVILATIFKYWIFRYLNRVSPSSVATLRGMNGGG
What is the function of this protein?
Involved in light-induced Na(+)-dependent proton extrusion.  Also seems to be involved in CO(2) transport.
What are the official names of this protein?
Proton extrusion protein PcxA.
What is the protein family that this protein belongs to?
Belongs to the Cema family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DER_VEREI
Sequence: MKPVMALVGRANVGKSTLFNRLTRSRDALVADFAGLTRDRHYGNGKQGRHEYIVIDTGGFEPDVASGIYREMARQTQQAIAEADVVVFVVDVRAGVTAQDHDIAHYLRRAGKPCVLAANKAEGMQQDQGGKWAEFYELGLGTVHPVSAAHGQGIRSLVEMALEPLSPPDDGADAAARDLPDADGVDGVDGVDGADGRIIRLAVAGRPNVGKSTLINTWLGEERLVAFDTPGTTRDAITVPFERNGQRFELVDTAGLRRKGKVFAAVEKFSVVKTLQAIESAHVVLLLLDASQGVTEQDAHIAGYILESGRAVVLAVNKWDATDDYQRQLLERSIETRLAFLKFASLHRISAKKRQGLGPLWTAIVQAHKAATCKMSTPVLTRLLLEAVQFQSPQRQGLFRPKMRYAHQGGMNPPVIVIHGNGLEHVTDTYKRFLEGRFRKEFDLVGTPLRIELKTSHNPYVDEGRGGR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: SYI_GEOTN
Sequence: MDYKETLLMPQTEFPMRGNLPKREPEMQKKWEEMDIYRKVQERTKGRPLFVLHDGPPYANGDIHMGHALNKILKDIIVRYKSMSGFCAPYVPGWDTHGLPIETALTKQGVDRKSMSVAEFRKLCEQYAYEQIDNQRQQFKRLGVRGDWDNPYITLKPEYEAQQIKVFGEMAKKGLIYKGLKPVYWSPSSESALAEAEIEYKDKRSPSIYVAFPVKDGKGVLQGDERIVIWTTTPWTIPANLAIAVHPDLDYYIVEANGQKYVVAAALAESVAKEVGWEAWSVVKTVKGKELEYVVAKHPFYERDSLVVCGEHVTTDAGTGCVHTAPGHGEDDFIVGQKYGLPVLCPVDERGYMTEEAPGFAGMFYDEANKAITQKLEEVGALLKLSFITHSYPHDWRTKQPTIFRATTQWFASIDKIRDQLLDAIKETKWVPEWGEIRIHNMVRDRGDWCISRQRAWGVPIPVFYGENGEPIITDETIEHVSNLFRQYGSNVWFEREAKDLLPEGFTHPSSPNGLFTKETDIMDVWFDSGSSHQAVLVERDDLERPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSLGNVVVPAKVMEQLGADILRLWVASVDYQADVRISDNILKQVSEVYRKIRNTFRFMLGNLFDFDPNQNAVPVGELGELDRYMLAKLNKLIAKVKKAYDSYDFAAVYHEMNHFCTVELSAFYLDMAKDILYIEAADCRARRAVQTVLYETVVALAKLIAPILPHTADEVWEHIPNRKEQVESVQLTDMPEPMAIDGEEALLAKWDAFMDVRDDILKALENARNEKVIGKSLTASVTVYPKDEVRALLASINEDLRQLLIVSAFSVADESYDAAPAEAERLNHVAVIVRPAEGETCERCWTVTPDVGRDESHPTLCPRCAHIVNEHYSA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAR2_SCHPO
Sequence: MAKKDKTSVKKSVKETASKKGAIEKPSKSKKITKEAAKEIAKQSSKTDVSPKKSKKEAKRASSPEPSKKSVKKQKKSKKKEESSSESESESSSSESESSSSESESSSSESESSSSESSSSESEEEVIVKTEEKKESSSESSSSSESEEEEEAVVKIEEKKESSSDSSSESSSSESESESSSSESEEEEEVVEKTEEKKEGSSESSSDSESSSDSSSESGDSDSSSDSESESSSEDEKKRKAEPASEERPAKITKPSQDSNETCTVFVGRLSWNVDDQWLGQEFEEYGTIVGARVIMDGQSGRSKGYGYVDFETPEAAKAAVAANGTKEIDGRMVNLDLSNPRPANPQPYAQQRAGNFGDQLSEPSDTVFVGNLSFNATEDDLSTAFGGCGDIQSIRLPTDPQSGRLKGFGYVTFSDIDSAKKCVEMNGHFIAGRPCRLDFSTPRTGGGSRGGRGGFGGRGGFGGRGGFGGGRGRGRGGARSGNPNRGSVAPFSGNKVTFD
What is the function of this protein?
Helps the assembly of pre-ribosomal particles containing 18S rRNA.
What are the official names of this protein?
Protein gar2.
What is the protein family that this protein belongs to?
Belongs to the RRM GAR family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: KAD_SCHMA
Sequence: MTDQKLAKAKVIFVLGGPGSGKGTQCEKLVQKFHFNHLSSGDLLRAEVQSGSPKGKELKAMMERGELVPLEVVLALLKEAMINWLTKIVISLSIRYPRELDQGIKFEKEVCPCLCVINFDVSEEVMRKRLLKRAETSNRVDDNEETIVKRFRTFNELTKPVIEHYKQQNKVITIDASGTVDAIFDKVNHELQKFGVK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCNC_HUMAN
Sequence: MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
What are the official names of this protein?
Cyclin-C, SRB11 homolog, hSRB11.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SELO_SALEP
Sequence: MTLSFTARWRDELPATYTALLPTPLKNARLIWYNDKLAQQLAIPASLFDATNGAGVWGGETLLPGMSPVAQVYSGHQFGVWAGQLGDGRGILLGEQLLAYGSTLDWHLKGAGLTPYSRMGDGRAVLRSTIRESLASEAMHYLGIPTTRALSIVASDTPVQRETQETGAMLMRLAQSHMRFGHFEHFYYRREPEKVQQLADFAIRHYWPQWQDVPEKYALWFEEVAARTGRLIAEWQTVGFSHGVMNTDNMSILGLTIDYGPFGFLDDYDPGFIGNHSDHQGRYRFDNQPLVALWNLQRLAQTLTPFIEIDALNRALDRYQDALLTHYGQRMRQKLGFFTEQKDDNALLNELFSLMAREGSDYTRTFRMLSHTEQQSASSPLRDTFIDRAAFDAWFDRYRARLRTEAVDDALRQQQMQRVNPAVVLRNWLAQRAIDAAEQGDMAELHRLHEVLRQPFTDRDDDYASRPPEWGKRLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: HEM1_ACAM1
Sequence: MNIAVVGLSHKTAPVDVREKLSIPDDVKEKATSQLRSYPHLEEVAILSTCNRMEVYVVAQETDDGIRELTQFLSEWSQIPLLELRQHLFILLHQDAVMHLMRVSAGLDSLVLGEGQILAQVKQTHKLSQKYSGAGPILNRLFKQAISAGKRVRTETSIGTGAVSISSAAVELAQIKTEDLSAHRVAIIGAGKMSRLLVKHLLSKGANQIAILNRSLKRAEQLADQFQGADLKLHTLADMQAVLTESDLIFTSTASTEPLLDRDILEPIVCDRQSCMIFDISVPRNVHSNVNELSQVHAFNVDDLKAVVAQNQESRRQMALEAESLLEEEVASFDVWWRSLETVPTISSLRTKVESIREQELEKALSRLGTEFAEKHQEVIEALTRGIVNKILHDPMVQLRAQQDIEVRRKAMQSLNMLFNLNSSQGVAKQRNT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: MEND_CHLL3
Sequence: MNNRQATTIWSAVLVEELIRQNASMFCISPGSRSTPLTAAVARNPRASWKMFPDERSAGFFALGHARATGRPAVLVCTSGTAVANYFPAVVEASADFVPMIVISADRPFDLQECGANQTIRQDGIFGRYARWHMQLPQPSTEIPLQSLLSTVEHAVAKSLGAPRGPVHLNQPFREPFDPEPLEGQDPWLEPLQAWKLDGRPRTSSAQPERRPDARAMATIRELLATARRPLLIAGSIPSPDDARAVASLADDLRIPLYADLSSGLRLTEGTLAWQQAFATPAFLGRFRPDLVVHFGGRLIARHPSAALKAWKPAHYVVIREHPERYAPDHPVSLSLESSLQTAAEGLMGCRSEPSAIKEPAEGFFLHCSGALDDLTEASIPLSEISAARQISQLITPGEALFTSNSMSVRELDSFAAALQPDGLPCGLNRGASGIDGIISTAAGYGEGLGRKVTLLIGDIAFLHDLNALSLLRSLSRPMRIVLLNNNGGGIFSFLPVASCNDIFEEHFATPQHFHAQHAAGMFGLRYAAPRTNREFEECFLAAGEAPQSTIIEIASSRSENVEQHRTLQARFNAFAETAFTDR
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: ISPH_NOCFA
Sequence: MSSAIPLNVGIARSAGTATVDADTAKRVLLAEPRGYCAGVDRAVETVEKALEKHGAPIYVRKEIVHNRHVVETLRERGVVFVDDTAEVPEGAVVVFSAHGVSPAVHEAAAARNLHTIDATCPLVTKVHQEAKRFARDDYDILLIGHEGHEEVEGTAGEAPEHVQLVDGPDAVDRVRVRDENKVIWLSQTTLSVDETMETVQRLRERFPSLQDPPSDDICYATQNRQVAVKAMAPECDLVIVVGSRNSSNSVRLVEVALNAGAKAAHLVDYAREVDPAWLEGVRTIGITSGASVPEILVRGVLDMLAEHGYADVQPVTTANETLVFALPRELRTTRR
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: CMC4_DEBHA
Sequence: MSSSSDKTDPCKPEACAIQDCLQQNNYNESKCSKIIDNLYLCCKKYYEKNGSDKQTTCCPKFNLLQLKLKQRELGKIDAEMVDSRKG
What are the official names of this protein?
Cx9C motif-containing protein 4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the CMC4 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Imported into the mitochondria via the mitochondrial disulfide relay system.
Protein: SEP11_MACFA
Sequence: MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTTKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVNNFQKKKAAVQLLQSQAQQSGAQQTKKDKDKKNSPWLCTE
What is the function of this protein?
Filament-forming cytoskeletal GTPase.  May play a role in cytokinesis (Potential).  May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
What are the official names of this protein?
Septin-11.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Synapse. Cell projection, dendritic spine. Cell projection, axon.
Protein: COPT1_PONAB
Sequence: MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSRGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH
What is the function of this protein?
Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells.
What are the official names of this protein?
High affinity copper uptake protein 1, Copper transporter 1, Solute carrier family 31 member 1.
What is the protein family that this protein belongs to?
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells.