PharMolix/UniProtQA huggingface dataset:
Protein: SDRE_STAAC
Sequence: MINRDNKKAITKKGMISNRLNKFSIRKYTVGTASILVGTTLIFGLGNQEAKAAENTSTENAKQDDATTSDNKEVVSETENNSTTENNSTNPIKKETNTDSQPEAKKESTSSSTQKQQNNVTATTETKPQNIEKENVKPSTDKTATEDTSVILEEKKAPNNTNNDVTTKPSTSEPSTSEIQTKPTTPQESTNIENSQPQPTPSKVDNQVTDATNPKEPVNVSKEELKKNPEKLKELVRNDSNTDHSTKPVATAPTSVAPKRVNAKMRFAVAQPAAVASNNVNDLIKVTKQTIKVGDGKDNVAAAHDGKDIEYDTEFTIDNKVKKGDTMTINYDKNVIPSDLTDKNDPIDITDPSGEVIAKGTFDKATKQITYTFTDYVDKYEDIKSRLTLYSYIDKKTVPNETSLNLTFATAGKETSQNVTVDYQDPMVHGDSNIQSIFTKLDEDKQTIEQQIYVNPLKKSATNTKVDIAGSQVDDYGNIKLGNGSTIIDQNTEIKVYKVNSDQQLPQSNRIYDFSQYEDVTSQFDNKKSFSNNVATLDFGDINSAYIIKVVSKYTPTSDGELDIAQGTSMRTTDKYGYYNYAGYSNFIVTSNDTGGGDGTVKPEEKLYKIGDYVWEDVDKDGVQGTDSKEKPMANVLVTLTYPDGTTKSVRTDANGHYEFGGLKDGETYTVKFETPTGYLPTKVNGTTDGEKDSNGSSVTVKINGKDDMSLDTGFYKEPKYNLGDYVWEDTNKDGIQDANEPGIKDVKVTLKDSTGKVIGTTTTDASGKYKFTDLDNGNYTVEFETPAGYTPTVKNTTADDKDSNGLTTTGVIKDADNMTLDRGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKDVTVTLQNEKGEVIGTTKTDENGKYRFDNLDSGKYKVIFEKPAGLTQTVTNTTEDDKDADGGEVDVTITDHDDFTLDNGYFEEDTSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDAGKHTPVKPMSTTKDHHNKAKALPETGSENNGSNNATLFGGLFAALGSLLLFGRRKKQNK
What is the function of this protein?
Cell surface-associated calcium-binding protein which plays an important role in adhesion and pathogenesis.  Contributes to the resistance to killing by innate immune components in blood and thus attenuates bacterial clearance by interacting with host complement factor H/CFAH and modulating its activity.  Inhibits also bacterial opsonization and killing by interacting with host complement regulator C4BPA and thus inhibiting classical complement pathway activation.
What are the official names of this protein?
Serine-aspartate repeat-containing protein E.
What is the protein family that this protein belongs to?
Belongs to the serine-aspartate repeat-containing protein (SDr) family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase A (By similarity).
Protein: GATC_RICTY
Sequence: MITKEEAQKIAKLARLKFEKDIVEKFSTQLSTIMNMINILNEIDCKDIEPLTSVSNMNARMREDTVTSSDLSNKLFDNVSGNSARLAKEVKYFITPKVVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RECO_DESHD
Sequence: MGVYHADALVIRSREYGESDRLLTLFSREYGKIQAVAKGVRKPKSRQRAGAQLFTYAEYLLHKGKSLDTVNQVSPRESFPHLWTDLDMSMAATAMAELLDLATLPGQPHPELFTLTFSSLFLVESCDPALVQCTYALKLMNYLGYRPRLVECAECGQRVQGERLLFSPDAGGVVCRQCQTQGSSPAVGRWVSGGSLGLMRQLLQGELEKLNRLRWNQWSKKEILEVSQYFCEQTLDKSLRSWSMGNRLVNVGQNPSGKDDLNERRDVDGTGES
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: PME_RALSO
Sequence: MQSKTLYLKATALLGGCTVFAATALAVTSTATRPQLSSADARTYTIAKYLASFGTIGSLTTDNWDPTGGVGAVSGFRANYAVAADGTAQYKTVQAAIDAAVNAGGVARRYISVKAGIYNELVCVPESAPPITLYGLDANAGNTQIVYNNANPTPASGAKTNPCMGTSSNATVGTLRSATAMVRASDFHARNLTFKNSYVEGTYADNNQSAVALAVRGDKAILENVSVIGNQDTLFVGATSTTTVIRAYFKNSFIQGDTDFIFGAGTAVFHGCTIQYTAARLGAKAASYIFAPSTAPGNPYGFLAINSTFNATGNPPNNSLHLGRAWDQSVSGTSAYINGSSPNGQVVIRDSSLGALIRLADPWGPSTAGRPYCSANCAYSANRFFEYNNTGAGSGN
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.
What are the official names of this protein?
Pectinesterase, PE, Pectin methylesterase.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYM_BACAA
Sequence: MSIFIGGAWPYANGSLHLGHIASLLPGDILARYYRAKGENVLYVSGSDCNGTPIAIRAKQEGVTAKEIANKYHEEFERCFRNLGFTYDCYTRTDSEHHHETVQNVFLRLLEEGHIYKKTVEQAYCETCTQFLPDCYVEGVCPHCHEEARGDQCDACSAILDPLDLLEKKCKLCGSTPSIQETEHFYFALHTFQEQIKRAVEIAKQTGTWRDNAIQLTERYVKEGLLDRAVSRDLPIGVPIPVEGYEDKKIYVWIEAVTGYYSASKHWAEETGKDDREFWDGEAKTYYVHGKDNIPFHSVIWPAVLLGIGEGTIPRHIVSNEYLTVEKRKLSTSKNWAVWVPDILERYDPDSIRYFLIVNAPENRDTDFSWREFIYSHNSELLGAYGNFVNRTLKFIEKYYGGIMPKGSIDVELKDKIERLYKHVGEAIEQTKFKVALESIFDAVRFANKYFDERQPWKEREDDPVSCEETIYNCVYLIANFANLLEPFLPFSSERIRNTLSIVNRNWEPQHTLPSRIDSVQPLFERIDVKQIECELEKLYGAVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG4A_BOVIN
Sequence: MESVLSKYENQITIFADYLEEFPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCRTLSLSADTPAERPLESLTASNQSKGPSACCTAWKPLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTADDQTFHCLQPPQRMNILNLDPSVALGFFCKEEKDFDSWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSI
What is the function of this protein?
(Microbial infection) Mediates cleavage of an ATG8 protein homolog coded in the genome of cytopathogenic bovine viral diarrhea virus (BVDV).
What are the official names of this protein?
Cysteine protease ATG4A, Autophagy-related cysteine endopeptidase 2A, Autophagin-2A, bAut2A, Autophagy-related protein 4 homolog A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXNL1_HUMAN
Sequence: MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH
What is the function of this protein?
Active thioredoxin with a redox potential of about -250 mV.
What are the official names of this protein?
Thioredoxin-like protein 1, 32 kDa thioredoxin-related protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated.
Protein: S39A3_BOVIN
Sequence: MVKLLVAKILCMVGMFFFMLLGSLLPVKIIEMDFEKAHRSKKILSLCNTFGGGVFLATCFNALLPAVREKLKEVLTLAHISTDYPLAETIMLLGFFMTVFLEQLVLTFRKERPAFIDLETFNASSDAGSDSEYESPFMGGPRGHALYAEPHGHSHGLSVQELSRSSPLRLLSLVFALSAHSVFEGLALGLQEEGEKVVSLFVGVAIHETLVAVALGINMARSAMALRDAAKLAVTVSAMIPLGISLGLGIDSAQGMPSSVASVLLQGLAGGTFLFVTFFEILAKELEEKSDRLLKVLFLVLGYTVLAGMVFIKW
What is the function of this protein?
Transporter for the divalent cation Zn(2+).  Mediates the influx of Zn(2+) into cells from extracellular space.  Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus.  Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen.
What are the official names of this protein?
Zinc transporter ZIP3, Solute carrier family 39 member 3, Zrt- and Irt-like protein 3, ZIP-3.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL28_SPOFR
Sequence: MSSHLNWMIIRNNNAFLVKKRNIKKPFSKEPNNVTNLNSYRYNGLIQKKAVGVVENPDRKGFTVVYKKAKATNKPAKNAVRRQFKAGARRSLYKVKRLLKANHYRTDLSKATLRRASAILRSQRPIKAKKPKAAVAKTE
What are the official names of this protein?
60S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL28 family.
Protein: MSHA_MYCLE
Sequence: MLAVHTSPLAQPGIGDAGGMNVYVLQSALHLARRGIEVEIFTRATASADPPIVWVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAAHEPGYYDIVHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDAAEPPLRSVGEQQVVDEADRMIVNTDDEARQLISIHRADPAKIDVAHPGVDLDMFRPGDRRAARAALGLPLDGNVVAFVGRIQPLKAPDIVLRAAAKLPQVRIVVAGGPSGSGLASPDGLVRLADELGITARVTFLPPQSRTNLATVFQAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGVTGTLVFGHNVGHWADAVDQLLRLSAGPQARAISRAAVVHAAQFSWDNTTDALLASYRRAIGDFTATRQHRVRDLVATRKPRRWISRRGMGA
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: FABZ_STUS1
Sequence: MDINEIREYLPHRYPFLLVDRVTELDVEAKRVRAYKNVTINEPFFNGHFPQHPIMPGVLIIEAMAQAAGLLGFKMMGVKPSDGTLYYFVGSDKLRFRQPVRPGDQLVLEADFLSNKRGIWKFDCRATVDGRPVCSAEIICAEQEI
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
Protein: AROE_XYLFA
Sequence: MPVSRFAVFGHPIAHSLSPRIHTEFGRQMGVALNYLAFDVAPDAFRVSLERFVAEGGCGANVTLPLKEAAFEVCTTLSARARRAGAVNTLSRVDGVWHGENTDGTGLVRNLTERHGLDLRGRRALLLGAGGAARGVAPALLDAGITEMVIVNRSPERADMLCDALGEPGRVSARYWGDLGDLGNFELIVNATSIGNTSDMRTFSLPRSLLDSMTAAVDLNYGSAAVPFLAWAHAVETRYVIDGLGMLVEQAAESFSLWHGRRPDTDPVYTVLHSEYGAPGRS
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: ENV_FLVC1
Sequence: MEGPTHPKPSKDKTFSWDLIILVGVLLRLDVGMANPSPHQVYNITWTITNLVTGTKANATSMLGTLTDAFPTLYFDLCDIIGNTWNPSGQEPFPGYGCDQPMRRWQQRNTAFYVCPGHANRKQCGGPQDGFCAVWGCETTGETYWKPTSSWDYITVKKGVTQGIYQCSGGGWCGPCYDKAVHSSTTGASEGGRCNPLILQFTQKGRQTSWDGPKSWGLRLYRSGYDPIALFSVSRQVMTITPPQAMGPDPVLPDQKPPSRTVSPQLNVIPHPS
What is the function of this protein?
The surface protein (SU) attaches the virus to the host cell by binding to its receptor.  This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide.  Fusion occurs at the host cell plasma membrane (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM.
Protein: IXTPA_GRAFK
Sequence: MKLVFATHNPNKFREIKSLVPKHIELLSLSDINCNEDIEETGDTIDENAMIKADYVRNHYGYDCFADDTGLEVHSLAGAPGVYSARYAGDEKNDEANIEKLLEQLKKRDDRTARFKTVIALNLKGNQNLFTGICEGEILEEKTGTKGFGYDPIFLPNGFESSFAEMELTEKSKISHRGIAFRELMEYLSK
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: POTB_MYCGE
Sequence: MHIKKKYWLLLPFFLLMTIFFIIPMAWIIVSGLQSEDGASISQKYEPLVSGLGFFNSFWTSLWISIVTVIVALLFSFPFCYFLSQSKNKIFKAFVISIATVPIWSSFLIKLIGLKTLLDLLIGLSLNRVGDNNLTFGSGYTLLGTIYLFTPFMFLPLYNHFCVLPKNLLLASQDLGYNWIYSFVKVVIPFSKTAMLSGIALTFFPALTSVAIAQFLDNSNQAETLGNYIFTLGNNGYDSAIERGRAAGAIIIAALITFAIYFTVVFLPKIVRIVHNKWKQHEKAF
What is the function of this protein?
Required for the activity of the bacterial transport system of putrescine and spermidine.
What are the official names of this protein?
Spermidine/putrescine transport system permease protein PotB homolog.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TGT_SORC5
Sequence: MSRTPGFSFSELARDGHARTGVLSTPHGDVLTPTFMPVGTQGSVKTLTPAEVAATGARIVLGNTYHLWLRPGPELVAQLGGLHAFTRWPHAMLTDSGGFQAFSLAERRTLVEDGFVFRSHLDGARKALTPEVAMEVQGLLGADIAMQLDVCPPGGAPRPEVEEACRLTTRWGKRCLAAKRPSQALFGIVQGGTSVALRMAHADELGALPFDGLALGGFSVGEPIAMMHEVVAQIGPHLDPTRPRYLMGVGTPIDLVHAIGAGVDMFDCVLPTRNARNGQALTQHGKIVIKQARYKEDRSPLDPTCACPTCTGGYSRAYLRHLYMAGEILVLRLLTEHNLHLYGRLMREARAAIAEGRYAAFARAWLGASDAGNANDANETVGATESTESTESTE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: SUB5_TRIRU
Sequence: MTGFFTILSFSLAALSVTNAAQILSVPKGAEVVPNGYIVVMKDDTSQQDFSSHRVWISSIHHNMTRRGLDGAGVKQTYDFDHLRGYSGIFDEDTIKDISNDPKVAFVEPDAIISQHVVVQQRKAPWGLSRLSNRRGGRNYVFDSSAGSGVWAYVVDSGVDIRHSEFQGRAVWGSNLVDNKNSDGTGHGTHVAGTIAGKTYGIAKKAKVVAVKVLNSEGKGPTSGIIAGINWSIRHARKHGMLQKSVLNMSLGGTYSAGLNHATAQAIKAGMFVSVSAGNDNINSNGNSPASERSVCTIAASTENDGKASFSNWGPAVDLYAPGHNILSARPGGGSQTMSGTSMAAPHAAGVAAYLIAKEGIPGNRACLRLKQLSQPTIRNPGPDTTSRLLYNGSGR
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENV_HV2G1
Sequence: MCGKSLLCVASLLASAYLVYCTQYVTVFYGVPVWRNASIPLFCATKNRDTWGTIQCKPDNDDYQEITLNVTEAFDAWDNTVTEQAVEDVWSLFETSIKPCVKLTPLCVAMSCNSTTNNTTTTGSTTGMSEINETSPSYSDNCTGLGKEEIVNCQFYMTGLERDKKKQYNETWYSKDVVCESNNTKDGKNRCYMNHCNTSVITESCDKHYWDAIKFRYCAPPGYALLRCNDTNYSGFEPKCSKVVASTCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTIISLNKYYNLSIHCKRPGNKTVVPITLMSGLVFHSQPINTRPRQAWCWFKGKWREAMQEVKQTLIKHPRYKGTNDTKNINFTKPGRGSDPEVAYMWTNCRGEFLYCNMTWFLNWVENRPNQTQHNYAPCHIRQIINTWHKVGKNVYLPPREGQLTCNSTVTSIIANIDVNSNQTNITFSAEVAELYRLELGDYKLIEVTPIGFAPTREKRYSSAPVRNKRGVFVLGFLGFLATAGSAMGAASLTLSAQSRTLLAGIVQQQQQLLDVVKRQQEMLRLTVWGTKNLQARVTAIEKYLKDQAQLNSWGCAFRQVCHTTVPWVNDSLSPDWNNMTWQEWEKQVRYLEANISQSLEQAQIQQEKNMYELQKLNSWDVFGNWFDLTSWIKYIQYGVYIVVGVIVLRIAIYIVQLLSRLRKGYRPVFSSPPGYLQQIHIHTDRGQPANEGTEEDDRDDDGYDLPWPINYIHFLIHLLTRLLTGLYKICRDLLSTNSPTHRLISQNLTAIRDWLRLKAAYLQYGGEWIQEAFQAFAKTTRETLASAWGGLCAAVQRVGRGILAVPRRIRQGAEIALL
What is the function of this protein?
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers.  Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells.  Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells.  This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: CHEB1_ANADE
Sequence: MAPRILVVDDSAVVRMALSQILGRAGLEVETAIDPLVAMDKMRRARPDAIVLDIEMPRMDGLTFLDRVMAQDPVPVVVCSGLAGPGSEVALHALEHGAVDVIEKPRLGVKGFLEDSARRIVEVVRAATQARLRARVRALRPLPRPPAGAQPRPAPRLAPRAGRAELVVVGASTGGTEALRVLLEAMPADAPAIAVVQHMPEVFTAQFAKRLDKLCRIEVKEAADGDRLLPGRALVAPGNRHLSVKRAGGLVAVVSDGPPVSLHRPSVNVLFHSAARVAGPGTLGILLTGMGDDGADGLLELRRAGAHTVAQDESTSVVFGMPKEAIARGAAVEVLPLPRVASAVLAWAR
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 1.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FP100_HUMAN
Sequence: MAGAAPRVRYLAGFCCPLGGLAAGKPRVLCHEAEVFLSTGSELVYVYDQEGGLLTAAFRFPDQVWHLELLAPRRLLYALCARRGLYCLSLDHPGRSRSTSQDDRDSEDGDQPSPVIPVDPDACILPDAALCAFTLLDSVLVTLVQGPARWKMQLFEQPCPGEDPRPGGQIGEVELSSYTPPAGVPGKPAAPHFLPVLCSVSPSGSRVPHDLLGGSGGFTLEDALFGLLFGADATLLQSPVVLCGLPDGQLCCVILKALVTSRSAPGDPNALVKILHHLEEPVIFIGALKTEPQAAEAAENFLPDEDVHCDCLVAFGHHGRMLAIKASWDESGKLVPELREYCLPGPVLCAACGGGGRVYHSTPSDLCVVDLSRGSTPLGPEQPEEGPGGLPPMLCPASLNICSVVSLSASPRTHEGGTKLLALSAKGRLMTCSLDLDSEMPGPARMTTESAGQKIKELLSGIGNISERVSFLKKAVDQRNKALTSLNEAMNVSCALLSSGTGPRPISCTTSTTWSRLQTQDVLMATCVLENSSSFSLDQGWTLCIQVLTSSCALDLDSACSAITYTIPVDQLGPGARREVTLPLGPGENGGLDLPVTVSCTLFYSLREVVGGALAPSDSEDPFLDECPSDVLPEQEGVCLPLSRHTVDMLQCLRFPGLAPPHTRAPSPLGPTRDPVATFLETCREPGSQPAGPASLRAEYLPPSVASIKVSAELLRAALKDGHSGVPLCCATLQWLLAENAAVDVVRARALSSIQGVAPDGANVHLIVREVAMTDLCPAGPIQAVEIQVESSSLADICRAHHAVVGRMQTMVTEQATQGSSAPDLRVQYLRQIHANHETLLREVQTLRDRLCTEDEASSCATAQRLLQVYRQLRHPSLILL
What is the function of this protein?
Plays a role in Fanconi anemia-associated DNA damage response network.  Regulates FANCD2 monoubiquitination and the stability of the FA core complex.  Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed.
What are the official names of this protein?
Fanconi anemia core complex-associated protein 100, Fanconi anemia-associated protein of 100 kDa.
What are the subcellular locations of this protein?
Nucleus.
Protein: CRF3_ARATH
Sequence: MDEYIDFRPLKYTEHKTSMTKYTKKSSEKLSGGKSLKKVSICYTDPDATDSSSDEDEEDFLFPRRRVKRFVNEITVEPSCNNVVTGVSMKDRKRLSSSSDETQSPASSRQRPNNKVSVSGQIKKFRGVRQRPWGKWAAEIRDPEQRRRIWLGTFETAEEAAVVYDNAAIRLRGPDALTNFSIPPQEEEEEEEPEPVIEEKPVIMTTPTPTTSSSESTEEDLQHLSSPTSVLNHRSEEIQQVQQPFKSAKPEPGVSNAPWWHTGFNTGLGESDDSFPLDTPFLDNYFNESPPEMSIFDQPMDQIFCENDDIFNDMLFLGGETMNIEDELTSSSIKDMGSTFSDFDDSLISDLLVA
What is the function of this protein?
Component of the cytokinin signaling pathway involved in cotyledons, leaves, and embryos development.  Probably acts as a transcriptional activator.  Binds to the GCC-box pathogenesis-related promoter element.  May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).
What are the official names of this protein?
Ethylene-responsive transcription factor CRF3, Protein CYTOKININ RESPONSE FACTOR 3.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. ERF subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Relocalization from the cytoplasm into the nucleus is induced by cytokinins.
Protein: ACCA_RHILO
Sequence: MYNYLDFEKPVQDLELKILELKKLAENGEAVDVADEITRLEKRSRDALRDLYKALTPWQKVQVARHSDRPHCVDYIKGLFSDFTPLAGDRNFGEDQAIVGGFARFRGEPVAIIGQEKGSDTTSRLRHNFGSVRPEGYRKAVRLMELADRFKIPLLTLVDTAGAYPGVGAEERGQAEAIARSTSACLALKVPSISVVIGEGGSGGAIAIATANRVYMLEHAIYSVISPEGAASILWRDTTRSKDAATNMKITAQDLLELKIIDAIIPEPMGGAQRAPEKVIAATGDLIAKTMKEFAGANTDFREQRREKYLAMGRSL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_YERE8
Sequence: MSLDIAKYPTLALAENPEELRMLPKESLPKLCDELRQYLLASVSRSSGHFASGLGVVELTVALHYVYNTPFDSLVWDVGHQAYPHKILTGRREQIGTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAGLGMAVAAEREGKGRRTVCVIGDGAITAGMAFEAMNHAGDIHSDMLVILNDNEMSISENVGGLNNHLAQLLSGKLYTSLREGGKKAFSGLPPIKDLLKRTEEHLKGMVVPSTLFEELGFNYIGPVDGHDVQALTQTLKNMRSLKGPQLLHIMTKKGKGYAPAEKDPIGWHAVPKFDPASGTLPKSQGNIPTYSKIFGEWLCETAAKDSQLMAVTPAMREGSGMVRFSREYPQQYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQLIHDVAIQNLPVLFAIDRGGLVGADGQTHQGAFDLSFMRCIPNMAIMTPSDENECRQMLHTGYHHNGPAAVRYPRGNGTGAVLEPLAIMPIGKGIVRREGEKVAILCFGTLLAQAQIVADNLNATLVDMRFVKPLDEELVLELAASHEVLVTVEENAIMGGAGSGVNELLMAKRQLVSVLNLGLPDHFVPQGEQDEMRAEFGLDAAGIQSQIEAWLE
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.