PharMolix/UniProtQA huggingface dataset:
Protein: GSA_SHESM
Sequence: MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKADGAYIYDADGKAYIDYVGSWGPMILGHNHPKIREAVLAAVHNGLSFGAPTELEVQMAEKVIAMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPIEIACIIIEPVAGNMNCIPPIPGFLEGLRTMCDEFGALLIIDEVMTGFRVSRSGAQGHYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGLYEALSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQEQITRFDQVTKCNIEHFRTFYHGMLDEGVYLAPSAYEAGFLSMAHGEEELRLTLEAADRVLARMKAAM
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFC5_NEUCR
Sequence: MALIVDKHRPRSLDALTYHTELSERLRSLAQSGDFPHLLVYGPSGAGKKTRIVATLKELYGPGVEKIKIDARVFQTSSNRKLEFNIVASVYHLEITPSDVGNYDRVVVQDLLKEVAQTQQVDLSAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTANIIAPIRSRCLLVRVAAPTHKEICDVLASSAKKEGWPIVKGLHQRIAEESGRNLRRALLMYEAVYAQNEKVTDSTPIPPPDWEALIGQIAKEIMEEHTPARILQVRAKLYDLLTHCIPATIILKTLTFKLIPLIDDALKADVIYWSAFYEHRIRTGTKVIFHLEAFVAKFMRIFEMYLMSMDL
What is the function of this protein?
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
What are the official names of this protein?
Replication factor C subunit 5, Replication factor C5, Probable activator 1 subunit 5.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TSP_BPSAV
Sequence: MATQSFSVAPSVQWTERDATLQTSPSVVVQGATVGKFQWGEVELPVLVTGGETGLVKKFFKPNDSTATDFLVIADFLSYSSMAWVTRVVGPLAKNSVTKGQTAITIKNKLDFETASPSASITWAGRYPGSLGNDIAINVCDSAGFPTWEFRNNFAYAPQSGEFHVVVVDKVGRITDSAGAVGQVDRISVSGTATAAGTISVAGEDIAYLDTDTPATLATKIGAALTALTDVYSSVVVKSNTVIVTHKAIGPQTVTAIVPDDKGLTATAVITTVGASGSIIEKYELMQNTQGSKKSDGANAYFKDVINDTSNWVYTFATALAAGVVELEGGVDDYNINRVAAIQVLNNAEAYDAKPVFAYCEELIEQQALIDLSTERKDTVSFVSPLRDTVVGNRGREMDDVVSWRESLVRDSSYFFMDDNWAYVYDKYNDKMRWIPACGGTAGVWARSIEIAGIYKSPAFHNRGKYNNYNRMAWSASSDERAVLYRNQINSIVTFSNEGIVLYGDKTGLTRPSAFDRINVRGLFIMAEQNIAAIAKYYLGENNDAFTRSLFSNAVRPYIRQLANMGAIYDGKVKCDEDNNTADVIAANQMVAGIWLKPEYSINWVYLDFAAVRPDMEFSEIESGGGIVAAS
What is the function of this protein?
Polymerizes as an extended structure around the baseplate-tail tube complex.  During ejection, the sheath shifts to a contracted form, thereby making the inner tail tube protrude through the host cell envelope.
What are the official names of this protein?
Tail sheath protein, TSP.
What is the protein family that this protein belongs to?
Belongs to the myoviridae tail sheath protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Tail.
Protein: FER4_ZYMTI
Sequence: MFALAQHTARRTLSRQQWTKVVVSAANYSSGSLSSTIRISSIPAPHTGEITVLSLNRPRARNAISTALLGELNTVVEQLHAQGDKSSTRALILTSESDDAFCAGADLKERLTFTEEDTRNFLKTLRHTFTRLSTLPIPTISAISSIAFGGGLELALCTNFRVLASTASIGLPETRLAIIPGGGGTYRLPALIGETRARDLILTGRRVSGEEAYFIGLADRLVQISEQELGEKGVARGRVLEEATAMAKGICEGGPVAIRAAQAAVSGWRDGEGSENKAYERVIPTKDRLEALTAFGEKRKPSFQGR
What is the function of this protein?
Enoyl-CoA isomerase/hydratase involved in the biosynthesis of a ferrichrome A-like siderophore which may contribute to organismal virulence (Probable).  The first step of siderophore biosynthesis is performed by the HMG-CoA synthase (HMGS) MYCGRDRAFT_54740 which catalyzes the generation of HMG-CoA and CoA using acetoacetyl-CoA and acetyl-CoA as substrates (By similarity).  The enoyl-CoA isomerase/hydratase MYCGRDRAFT_76805 then catalyzes the conversion of HMG-CoA to methylglutaconyl-CoA (By similarity).  The acyltransferase MYCGRDRAFT_85486 then fuses methylglutaconyl-CoA with hydroxyornithine to yield methylglutaconyl hydroxyornithine (By similarity).  Methylglutaconyl hydroxyornithine is then available for use by the nonribosomal peptide synthetase NRPS2 to generate the ferrichrome A-like siderophore (By similarity).
What are the official names of this protein?
Enoyl-CoA isomerase/hydratase MYCGRDRAFT_76805, Ferrichrome A-like siderophore biosynthesis protein MYCGRDRAFT_76805.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: RPOC_HAEDU
Sequence: MKDLVKFLKAQSKSNDDFDVIKIGLASPDKIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRDRMGHIELACPVAHIWFLKSLPSRIGLILDMPLRDIERVLYFESYVVTEPGMTDLEKNQLLTEEQYLEAEERWGDEFDAKMGAEGIQVLLRDMDLEHQCEVMREELQETNSETKRKKITKRLKLLEAFQQSGNKPEWMVMTVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLGLVAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLHLHQCGLPKKMALELFRPFIYSKLESRGIASTIKAAKKMVEREEPIVWDILAEVIREHPILLNRAPTLHRLGIQAFEPLLIEGKAIQLHPLVCAAFNADFDGDQMAVHVPLTLEAQLEARALMMSTNNVLSPASGDPIIVPSQDVVLGLYYMTRDKVNGKGEGMYFLDPREAEKAYRTGQVELHARVKVRITEYSKNEAGEFLAETNLVDTTIGRAILWMIAPKGMPFSVFNQTLGKKAISKLINESYRRLGLKESVVLADQIMYTGFAYAARSGVSVGIDDMVIPAQKNDIITAAEAEVAEIQEQFNSGLVTAGERYNKVIDIWAAANERVAKAMMENLSTEEMLNREGNPEKQASFNSIFMMADSGARGSAVQIRQLAGMRGLMARPDGSIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVITEDDCGTHEGIVMTPLIEGGDVKEALRDRVLGRVVAEDVLKPGTEQILIPRNTLIDEKWCDVIDVESVDVIKVRSVVTCNTDFGVCAKCYGRDLARGHLINQGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASAAAKESSIQVKNAGTIKLANAKFVTNKEGKIVLTSRNTELTVIDIFGRTKENYKVPYGAVLSKNDGAEVGVGEIVANWDPHTMPVISEVSGRIQFSDIVDGLTVARQTDDLTGLSSIVVQDVGERATAGKDLRPALRLVDAKGNDIFIPGTDVAAQYFLPGKAIVTLDDGAEIAVGEALARIPQESVGTKDITGGLPRVADLFEARKPKEAAILAEISGIVSFGKETKGKRRLVITPAEGEAFEEMIPKWRQLNVFEGEMVQRGDIISDGAETPHDILRLRGVHAVTDYIVNEVQEVYRLQGVKINDKHIEVIVRQMLRKAVITNAYDSEFLEGEQVEVARVKIANRKRAEEGKPLVEFERELLGITKASLATESFISAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGFAYHQARAKKRVVAEQPFEMPVSKNAFATEADIEAEFEFVADEATQNLAALLNATDEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: ADDA_STRSY
Sequence: MDGTNERRSGLMAFEQFLSAEEIKAVQLAEAHSDKQQKRTAEQIEAIYTHGQNVLVSASAGSGKTFVMVQRILDKLKRGIGIDQLFISTFTVKAAGELKERIEKKLNETIAETTDMELRRHLSAQLADLTKADIGTMDSFTQKLVTTYGYSLGISPQFRILQDETEKASLKKEVFDQLFADYLEEDENGAFRKLVRNFSGNRKDNSGFRQVVYQVHDFSQSTSSPTKWLKEQAVQADLYSQERIEQMLEQGFKEKVLDKLYQAADFFRYHVEWGRNDFGSAKYFANVEEVLDLLTGLDSLDQKDLMERVERILLINNQSRGKGLTNANRPKDEHLIAFKEEYNAGKSQIISELRDLGQEVYELTLLKDYQVQALPLLILLRDFVLDFSQAYLDVKIKEAAFEFGDIGHFAIRILEENADIRQFFQEKYHEVMVDEYQDNNHSQERMLDLLSNGHNRFMVGDIKQSIYRFRQADPMIFQEKFELYQANPQSGKLILLKENFRSQIEVLEATNAIFTRLMDRQVGEIKYDDTHSLVAGSPGQKIAQPKNEMEYLIYDQQDSANSSTDAEEETPLTAGEIEVVAKEIIRLHNEEGADFKDITLLVQKRTHNDLIMSIFEKHGIPIVADGGAASYLQSLEVMIMLDTLRVINNPLNDYALVALLKSPMFRFDEDELTRISLQAGTGFFYQKMEIAQQASGQHPELMSEKLKKKITDFLSILENWRAYAKLHSIYDMIWKMFNEKFYYDYVGALPNGSKRQANLYALGLRANQFEKTGYKGLSRFIAMIDRALANDKDLADVQEFLPQNAVQLMTIHKSKGLEFKYVFLMNIDKRFNLEDHYQSVIISRKNGLGIQYLADMKDKVNSPLPQVRVLMNTLPYQNNLQELKIANLSEQMRLLYVALTRAEKKLYLVGKGNADKLAEKYDGKKENGVLAQSTRESMATFQDWILAIDEAFSGEDLHFKKVFVTDEDLTEEKIGKLTLKSKLEDASLKDIRQSEDIAQALDQLSSVQELNERYKAAIELPSLRTPSQIKKLYEPILEQEGMEVMEKYQPKRTFNLPDFSKKPKITGAQVGSAVHELMQRLDLSWLVTEDTVRAALEAVHAEQAIKDKINVQMILDFFDTDLGREILANTDKLHREAPFASLQTDSVSQENFVLRGIIDGYLLYDDHIVLFDYKTDKYDQPIQLSQRYQAQMQLYAEALKKAYKIDRVDCHLILLGGERIEVVEVNI
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: ECFA1_LACLS
Sequence: MNKILEVENLVFKYEKESDVNQLNGVSFSITKGEWVSIIGQNGSGKSTTARLIDGLFEEFEGIVKIDGERLTAENVWNLRRKIGMVFQNPDNQFVGATVEDDVAFGMENQGIPREEMIKRVDEALLAVNMLDFKTREPARLSGGQKQRVAVAGIIALRPEIIILDESTSMLDPTGRSEIMRVIHEIKDKYHLTVLSITHDLDEAASSDRILVMRAGEIIKEAAPSELFATSEDMVEIGLDVPFSSNLMKDLRTNGFDLPEKYLSEDELVELLADKLG
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PQSH_PSEAB
Sequence: MTVLIQGAGIAGLALAREFTKAGIDWLLVERASEIRPIGTGITLASNALTALSSTLDLDRLFRRGMPLAGINVYAHDGSMLMSMPSSLGGSSRGGLALQRHELHAALLEGLDESRIRVGVSIVQILDGLDHERVTLSDGTVHDCSLVVGADGIRSSVRRYVWPEATLRHSGETCWRLVVPHRLEDAELAGEVWGHGKRLGFIQISPREMYVYATLKVRREEPEDEEGFVTPQRLAAHYADFDGIGASIARLIPSATTLVHNDLEELAGASWCRGRVVLIGDAAHAMTPNLGQGAAMALEDAFLLARLWCLAPRAETLILFQQQREARIEFIRKQSWIVGRLGQWESPWSVWLRNTLVRLVPNASRRRLHQRLFTGVGEMAAQ
What is the function of this protein?
Involved in the terminal step of the biosynthesis of quinolone which in addition to serve as a potent signal for quorum sensing, chelates iron and promotes the formation of membrane vesicles (MVs).  Catalyzes the hydroxylation of 2-heptyl-4-quinolone (C7-HHQ) to yield 2-heptyl-3-hydroxy-4-quinolone (PQS).  PqsH is also able to hydroxylate HHQ analogs having alkyl side-chain lengths of 3 (C3-HHQ), 5 (C5-HHQ) and 9 (C9-HHQ) carbons, however catalytic efficiencies are significantly reduced for substrates with alkyl side-chain lengths below 7 carbons.
What are the official names of this protein?
2-heptyl-3-hydroxy-4(1H)-quinolone synthase, 2-heptyl-3,4-dihydroxyquinoline synthase.
What is the protein family that this protein belongs to?
Belongs to the 3-hydroxybenzoate 6-hydroxylase family.
Protein: GYRA_LAWIP
Sequence: MSQTEHHISIEQEMRKSYLEYSLSVIIGRAIPDVRDGLKPVHRRILFAQQELGNSYTRPPKKCARIVGDVIGKYHPHGDSAVYDALVRMAQDFSMRDPLEEGQGNFGSIDGDAPAAMRYTEVRMSRLASEFLSDIDKETVDFRPNYDNSLEEPIVLPTKVPNLLLNGSSGIAVGMATNIPPHNLGELCNALLKIIDDPDVPIDNLLNIIHGPDFPTGGFIYVGQGLYDAYTKGRGTVKVRGKVEIEERKKGAQSIVIREIPFGLNKSSLVEKIAILVNERKIDGIADLRDESDRKGIRVVIELKKGVIPEIIINALYKFTPLETSFGINMLAVVDNRPQLLTIKSALTYFLDHRREVIVRRTRFELNKAEARLHILIGLIHALDHIDEVVNLIRSSSTPAEAKIRLIERFSLSEIQAQSILDMRLQRLTGLEREKLEEEMHELQTKIAWYESILGDTKILWGVIRDEVTGIKEMYTTPRRTEVIRETLTNIEIEDLIPDDDVVITLSRRGYIKRTNLAIYQQQRRGGKGVAGLHTSEDDFVQEFITTTNHQFLLLFTNKGRMHQLKVHQVPEGSRTAKGTHIANIVPLEKEEWVTTILTVREFSDNKFFLFATRKGMVKRSSASYYARSRRTGLLAVGLREDDELIMVKEVTNNDFIVLATAEGFAIRFSCEDVRNMGRGAAGVKGIALRPGDSVVACLILQEKQDTPAIMTVSNLGYGKRTSIDLYRVQTRGGKGIINFKVTQKTGLVIGAKPVSDDNALVLLTSTNKIIRMSVDEVRSAGRATMGVRLVKLDDGAYVVGFDTVDGTVDDSCDDATINT
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPE1_ARATH
Sequence: MASMAGPDHLFNLRNHFYLGAYQAAINNSEIPNLSQEDIVERDCLVHRAYIALGSYQLVISEIDEAAATPLQAVKLLAMYLSSPENKESTISSLREWLADPTVGNNAIIRLIAGTIFMHEEDYNEALKHTHSGGTMDLHALNVQIFIKMHRSDFAEKQLRVMQQIDEDHTLTQLASAWLNLAVGGSKIQEAYLIFQDFSEKYPMTSLILNGKAVCCMHMGNFEEAETLLLEALNKDAKDPETLANLVVCSLHVGKSSSRYLNQLKLSHPEHVLVKRAASAEDNFERALQSFA
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit epsilon-1, Epsilon-coat protein 1, Epsilon-COP 1.
What is the protein family that this protein belongs to?
Belongs to the COPE family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: SKI_HORSE
Sequence: MEAAAGGRGGFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAAAEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHTYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQTRLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRKTDDTPSQHPTSSEKDKQSGWLRTLASPSSKSLGCVHPRQRLSAFRPWSPAVSTSDKELPPHLPALIRDSFYSYKSFETGVAPNVALAPPAQQKVVSSPPCATVVSRAPEPLATCVQPRKRKLAVDTPGAPETPVPVAAPEDDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLSSPGVHVPPVAPAAADAAAPADTPSSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQVRVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRPRSEATGGESTAELEP
What is the function of this protein?
May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage.  Functions as a repressor of TGF-beta signaling (By similarity).
What are the official names of this protein?
Ski oncogene, Proto-oncogene c-Ski.
What is the protein family that this protein belongs to?
Belongs to the SKI family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLYA_PORG3
Sequence: MKKDSVIFDLIEKEHQRQLKGIELIASENFVSEQVMQAMGSCMTNKYAEGYPGKRYYGGCEVVDQSEQIAIDRIKQLYGAEWANVQPHSGAQANMAVLLACLEAGDTFMGLNLEHGGHLSHGSLVNSSGILYRPIGYNLSEETGMVDYDHMEKMAIEHKPKLIIGGGSAYSREWDYKRMREIADKVGALLMIDMAHPAGLIAAGLLENPVKYAHIVTSTTHKTLRGPRGGIILMGKDFDNPWGKKTPKGEIKKMSALLDSAVFPGVQGGPLEHVIAAKAVAFGEALDPSFKEYQTQVKKNAAVLAQAFMDKGYKVISGGTDNHSMLIDLRPKFPELTGKVAEKALVAADITVNKNMVPFDSRSAFQTSGFRVGTPAITTRGVKEDKMGYIVELIDRVLSAPEDEAVIASVRTEVNRMMADYPLFAW
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X92_TRYBB
Sequence: MDILRRTTSVELTRLPVSAADTLSDVVFPWQSLCFRLAMVFNNEGGKYDKDGRALMVAVGESNFVLMWRKLFNALCIAPVVVDGSDTQHKLNAESGSLHTSTSSSWCTYDPTRTGTLGKIAGKLFVVTAKCVCEGATLETTAPTSGEVEESGQGKETPIPRRIECVYDFHYTLPDFDIWGNDVTIGFLVMSHYSGNGNVDFVRSLDPTAARVKNLFKSPTVVLGTCHYRAVASRLLRCTSVARQISSTSVMICVNVANVAHVPVRVQEVSFDIYSTQMGEGDNDIGGVQLTHEQRFGPCGTDLKAIKLLQRTVTVTPLLLHGRCLEETLQPGESACFQFAIEVQPHLCHLLETHPRQEPHSRYANNTASVAVEAKNAPYSMRNDVSPILPHSPVAPQTVWRPSPIGTVECVPCSELKQVLFSKFVSQAYVSYNPIVSAGGESTDQRVASPLVSLSGTRCPGPCSRRGWPRSGKRRRGNTCSQLKLSPATCLHILRVCVCVCVCVFAFDGSKGAGQFYCVIGSLFFFRSFSLFLCPLLTVCLLRAKIFNI
What are the official names of this protein?
Protein X92.
Protein: SUMO2_DANRE
Sequence: MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLTMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGHRI
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 2, SUMO-2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMG_SALAI
Sequence: MPGPVDATPPPELATAARTLFGDRLDLAVAYAGLLVTDGVIRGLIGPREAPRLWDRHLLNCAAATERIPLGATVVDVGSGAGLPGLVLAVARPDLSVVLVEPLARRTAFLVEAVEQLELGASVRVVRGRAEEVAVGGAGVEPLTGDVVTARAVAPLDRLARWCLPLVVPGGRMVALKGASAAGEAAEHAAVVQRLGGGAPEVHQCGVGVVEPPTTVIEIRRERVVATPRPASAKRSRGGRRG
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_YERPG
Sequence: MKVAVLGAAGGIGQALALLLKTQLPSGSDLSLYDIAPVTPGVAVDLSHIPTAVNIKGFSGEDATPALQGADIVLISAGVARKPGMDRSDLFNVNAGIVRNLVEQIARTCPNALIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGITTLDTIRSNTFVAELKGKQPQDIEVPVIGGHSGVTILPLLSQIPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGESNVVECSYVEGDGKYARFFAQPILLGKNGVAERKDIGKLSAFEQQALENMLDVLHKDIELGEKFVNQ
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: MFS12_HUMAN
Sequence: MGPGPPAAGAAPSPRPLSLVARLSYAVGHFLNDLCASMWFTYLLLYLHSVRAYSSRGAGLLLLLGQVADGLCTPLVGYEADRAASCCARYGPRKAWHLVGTVCVLLSFPFIFSPCLGCGAATPEWAALLYYGPFIVIFQFGWASTQISHLSLIPELVTNDHEKVELTALRYAFTVVANITVYGAAWLLLHLQGSSRVEPTQDISISDQLGGQDVPVFRNLSLLVVGVGAVFSLLFHLGTRERRRPHAEEPGEHTPLLAPATAQPLLLWKHWLREPAFYQVGILYMTTRLIVNLSQTYMAMYLTYSLHLPKKFIATIPLVMYLSGFLSSFLMKPINKCIGRNMTYFSGLLVILAFAAWVALAEGLGVAVYAAAVLLGAGCATILVTSLAMTADLIGPHTNSGAFVYGSMSFLDKVANGLAVMAIQSLHPCPSELCCRACVSFYHWAMVAVTGGVGVAAALCLCSLLLWPTRLRRWDRDARP
What is the function of this protein?
Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation (PubMed:33208952).  In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation (PubMed:33208952).  Also catalyzes import of cysteine into lysosomes in non-pigmented cells (PubMed:33208952).
What are the official names of this protein?
Major facilitator superfamily domain-containing protein 12.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein: SRSF5_MOUSE
Sequence: MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIEGSKRHRSRSRSRSRTRSSSRSRSRSRSRRSKSYSRSRSRSRSRSKSRSGSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN
What is the function of this protein?
May be required for progression through G1 and entry into S phase of cell growth.  May play a regulatory role in pre-mRNA splicing.  Autoregulates its own expression.  Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity).
What are the official names of this protein?
Serine/arginine-rich splicing factor 5, Delayed-early protein HRS, Pre-mRNA-splicing factor SRP40, Splicing factor, arginine/serine-rich 5.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ILVB2_ORYSJ
Sequence: MAAAAAAASLSVSDAAAKLPKPGGQVQRRRDRDRPRVDAAACTRDSRRPTRERCSTTVSLAATATATTATPVRAPVRTRAPMGQRKGADIVVEALERCGVRDVFEYPGGASMEIHQALTRSPVIRNHLLRHEQGEAFAASGYARSSGRPGVCVATSGPGATNLVSALADAHLDSVPLVAITGQAPRRMIGTDAFQETPIVEFTRSITKHNYLILDVDDIPRVINEAFFLASTGRPGPVLVDIPKDIQQQMAVPSWDAPMRLPGYISRLPKPPAANLLDEVIRLVGDAERPVLYVGGGCSASGYELRRFVELTGIPVTTTLMGIGNFPSDDPLSLRMLGMHGTVYANYAVDNADLLLALGVRFDDRVTGKVEAFASRAKIVHVDIDPSELGKNKQPHVSICADVKLALQGMNAMLEEQSAAAARKNLDFSAWRSELEKKKVEFPLGYRTFGEEIPPQYAIQVLDEVTNGEAIVATGVGQHQMWATQHYTYRRPRQWLSSAGLGAMGFGLPAAAGAAVANPGATVVDIDGDGSLLMNIQELAMVRVEDLPVKVMVLNNQHLGMVVQWEDRFYDANRAHTYLGNPAANGGGEVYPDFVTIAGGFGIPAARVTRKGEVRAAVEEMMAAPGPYLLDVVVPHQEHVLPMIPSNGAFKDIIVDGDGRSSY
What are the official names of this protein?
Probable acetolactate synthase 2, chloroplastic, Acetohydroxy-acid synthase 2.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYK_BORPE
Sequence: MTDQSPAPTAQDENRLIAERRAKLARLRETGVAFPNNFVPDAHAADLHARYDGLDQEALTAAAVTVKVAGRMMLKRVMGKASFATLQDGSGRIQIYLERGTLGEEAYAAFKQWDIGDIIAIEGPVFKTNKGELSVHANSARLLSKSLRPLPDKFHGVADQELRYRQRYVDLIMTDATRRTFEARSKAVGGIRQAMLNAGFLEVETPMLHPIPGGAAAKPFVTHHNALDMQMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGVSPRHNPEFTMMEFYAAYADYRWLMDFTEDLIRQAAIAATGSAVLSYQDRELDLSQPFDRLTICEAILKYAEGYTQAQLDDPAFVRAELRKLGANVEGPPLARAGLGALQLALFEETAEAKLWRPTYIIDYPVEVSPLARASDTRDGITERFELFITGREIANGFSELNDPEDQAERFRAQVEAKDAGDEEAMYFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPSIRDVILFPHLRRED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDI2_RICRS
Sequence: MLKDQNLDIERKQDHIEINLTQNVESTLKSGFESIHFIHNALPELNYDSINTTTTFLGKSLQAPILISSMTGGTTRARDINYRLAQVAQKAGIAMGLGSMRVLLTEPDTIKTFAVRHIAPDIPLLANIGAVQLNYGVTPKECQYLVDAIKADALILHLNVLQELTQPEGNRNWEKLLPKIREVVHYLSIPVIVKEVGYGLSKKVAESLIDAGVKVLDIAGSGGTSWSQVEAYRATNSLQNRIASSFINWGIPTLDSLKMVREVSKDIPIITSGGLKSGIDGAKAIRIGANIFGLAGQFLKAADTSESLLFEEIQLIIEQLKITMLCTGSRTLKDLAKAEIRL
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_CHLFF
Sequence: MAVPRNRHSNARKNIRRSHDAKKARHAAVCNNCKQAFIPHTVCTSCGFYNGKAVMTVEKK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.