PharMolix/UniProtQA huggingface dataset:
Protein: MIAB_SYNPW
Sequence: MLPSRERGSYWITTFGCQMNKADSERMAGILESMGYREASAELDADLVLYNTCTIRDNAEQKVYSYLGRQAQRKRTNPNLTLVVAGCVAQQEGESLLRRVPELDLVMGPQHANRLETLLQQVDSGQQVVATEEHHILEDITTARRDSSICGWVNVIYGCNERCTYCVVPSVRGKEQSRLPDAIKLEMEGLAAQGFKEITLLGQNIDAYGRDLPGITPEGRRQHTLTDLLHHVHDVEGLERIRFATSHPRYFTDRLIDACADLPKLCEHFHIPFQSGDNDVLRAMARGYTVERYRRIIDRIRERMPDASLSADVIVAFPGETDAQYRRTLALIEEIGFDQVNTAAYSPRPNTPAADWDNQLPEDIKVERLREINALVERCARERNGRYAGRVEEVLAEGINPKDPSQLMGRTRTNRLTFFSATGADDRRYQAGDLVNVHIDAVRSFSLSGTPLNC
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1276_AERPE
Sequence: MSYITLTLPFNVGGSVAGDLFSTAWLFKTATHRMLSLAKQTPILPATDIGWKNTFRKAIYEVIPNRRYVDGVITLVRGIYESCRQLGVGFKEVELGDWLMFQQAEKEYPVRNITLKDDYSFYITTIGYNGEKDRIVVKPTIPKNYKVLLDKILEERQKHTARIVIKDYGVRKNRLWVHGEIQLTIPIDFYYKHMTRYRRNYGKLYGGVDVNVDRANLAVVDRYGRLRHVKTFWFEEASRKGCRSRRARSIIGMTVHDMLKYAYHHGVKTLFLENPDVLGKLKLLWIRNGKRLHRNYNWRVSVFRSRIIEMITMKTPLYAIRVEYVDPRRTTHSEEHDKIMKRYGLDRHSTSAYLIALRGIERYSSIQKVTA
What are the official names of this protein?
Uncharacterized protein APE_1276.
What is the protein family that this protein belongs to?
To A.pernix APE_1804 and S.solfataricus SSO2105.
Protein: S17AA_XENLA
Sequence: MSSPDGGYASDDQNQGKCSVPIMMTGLGQCQWAEPMTSLGEGKLKSDAGSANSRSKAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKSLTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRAENGFMHMAEAQESAVLGADGRMCLENFSLGYHEQTYPHGQVPQSSHYREPQAVAPHYDGYSLPTPESSPLDLAEADPVFFTSPAQDECQMMPYSYNGSYPHQQNSMLVRQMPQTEQMGQVSPVQGMMACQSSPHMYYGQMYLPGSARHHQLHQAGQPSPPPEAQQMGRADHIQPADMLAEVDRTEFEQYLSYVAKSDLGMHYHAQESVVPTADNGPISSVLSDASTAVYYCNYPSA
What is the function of this protein?
Transcriptional activator.  Binds to the DNA sequence 5'-AACAAT-3' (By similarity).  All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function.  In addition, the sox17 proteins have distinct but overlapping roles in later gut development.  Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly.  Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling.
What are the official names of this protein?
Transcription factor Sox-17-alpha-A, Xsox17alpha, xSox17alpha1.
What are the subcellular locations of this protein?
Nucleus.
Protein: NU4LM_PHOSU
Sequence: MMMAVLNISLAFIFSLLGTLMFRSHLMSTLLCLEGMMLTLFIITTITSLNSHSMVMYPIPIVILVFAACEAAVGLALLVKVSNTYGSDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS7_SCHPO
Sequence: MSALNKIVKRSSSQPTETDLLVAQCLYDLESSSKDMAKELRPLQITSAREVEVGGGKKAIVVFVPQPLLKAFHKCQARLTRELEKKFADRHVIFIAQRRILPKPGRKSRVTQKRPRSRTLTAVHNAILEDIVFPTEIIGKRTRQATDGRKTIKVFLDNRDANTVDYKLGSFSSVYHKLTGKNVTFEFPVATGEGL
What are the official names of this protein?
40S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS7 family.
Protein: NDK2_PSEMZ
Sequence: MIKPDGVQRGLVGEIISRGDFAIDIGR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase 2, Nucleoside diphosphate kinase II, NDK II, NDP kinase II, NDPK II.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
Protein: MSRA_STRA1
Sequence: MERAIFAGGCFWCMVQPFEELDGIESVLSGYTGGHVENPTYKEVCSKTTGHTEAVEIIFNPEKISYADLVELYWAQTDPTDAFGQFEDRGDNYRPVIFYENEEQRQIAQKSKDKLQASGRFDRPIVTSIEPADTFYPAEDYHQAFYRTNPARYALSSARRHAFLEENWH
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: NADK_RHOBA
Sequence: MSRSRFRGRITGWYLMASSSGEKLDWCGCGRPPRIVVLGAPDKLNVSSAWKRLRPTIQSHAELIAADFEFTYDFSDKEVDLVIVIGGDGSILQSARQMGENQTPVLGINCGRLGFLAALSPEDFLDAWPKVCQGDFSIIRHLMLEVQLIRDDEVIAQSMALNEAAILNGPPFAILDIDLYADGELATQYRCDGLIVATPVGSTAHNLSAGGPILRRQLQAIVISPISPHTLTYRPLVDSADTRLELAVTEPNESTSIVVDGRILGQLKSGDRVRVHRAPVSFEMLRVPGQNDYRTLREKLGWSGRLALRQL
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_CARAU
Sequence: MGAYKYMQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQIKFARSLQSVAEERAGRHCGGLRVLSSYWVGEDSTYKFFEVVLVDTFHKAIRRNPDTQWITKAVHKHREMRGLTSAGKKSRGLGKGHKFHLTIGGSRRAAWKRRNTLQLHRYR
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIB_PECAS
Sequence: MVTMNRLVLSGTVCKTPIRKVSPSGIPHCQFVLEHRSTQEEAGLSRQAWCRMPVIVSGLSSQAVTHSITVGTQLTVHGFISCHQGRNGLSKIVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: GET3_COCIM
Sequence: MSSAALVPADDILEPTLQSILDQKSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGFDNLSAMEIDPSASMQDLLAAGGEQGEDMGFGLGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKGLAKLSQLSNQFGPMLNSVLGARGGLPGGQNLDEVLSKMESLRETISEVNAQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYQIDTHAIVVNQLLFPGKDSTCEQCKARRKMQKKYLDEIAELYEDFNVVRMPLLVEEVRGKEKLERFSDMLVHPYQPPQE
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: TRPD_STRZJ
Sequence: MKEIIEKLAKFENLSGVEMTDVIERIVTGRVTEAQIASLLLALKMKGETPEERTAIAQVMRGHAQHIPTEIHDAMDNCGTGGDKSFSFNISTTAAFVLAGGGIHMAKHGNRSISSKSGSADVLEALGINLDLKPAELGKVFDKTGIVFLFAKNMHPAMKYIMPARLELGIPTIMNLTGPLIHPMALETQLLGISRPELLESTAQVLKNMGRKRAIVVAGPEGLDEAGLNGTTKIALLENGEISLSSFTPEDLGMEGYAMEDIRGGNAQENAEILLSVLKNEASPFLETTVLNAGLGFYANGKIDSIKEGVALARQVIARGKALEKLRLLQEYQK
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: LEU3_MYCSK
Sequence: MNLAIIAGDGIGPEVIGEAVKVLDAVLPEVEKTTYDLGARRYHATGEILPDSVLEELKVHDAILLGAIGDPSVPSGVLERGLLLRIRFALDHHINLRPAKLYSGVTGPLAGNPEIDFVVVREGTEGPYTGTGGAIRVGTPHEVATEVSLNTAFGVRRVVEDAFRRAQQRRKHLTLVHKNNVLTFAGALWWRTVQEVGAEYPDVEIAYQHVDSAMIHIVTDPGRFDVIVTDNLFGDIVTDLAAAVCGGIGLAASGNIDATRTNPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLAHVGETDAAARVDKAVEAHLSSRGDQELGTAAVGDRIVGLL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LST2_BRUMA
Sequence: MAVVKVEFAISGKLVNKPRVDDWNPLAKFYYADEALNAVANELDSFDGRRDPERCSQLVNKLRQAQDRLLHIISEMIQQVFPRESDRACRDYRVKFPEEIMHDNLPGQLWFGAEANVIPVFGCTFSCLTAGSNIIDHEVESEAIRPMARALTKHLDTLRDLLKDQSLRDPTHYSDKVKRSLKHFDHLFAEFELNYVSAMVPVKSVREYDCQLDIAVLFSEALDRAVRLDYLTQDQIDDCDPIVMIAVPRLAIVCGLLYFPEGALNVDANPETLSNMFRSFHSLLVKIRDLLRILNLHELRRVEKALCTGETQVKFGEDSIVETLTVANFHLKTTGKGTGRILEAQNLQPNGSSSSNSSDGGDCDVSSASGSVCHTNTFAYKILSPIRLKDSSESSSIENSSKLDLLIMTHPPDPHRLRARFRSSADLIHRLFVCICGVADQLQTNYPTDLRRVLKMILQPNDVVPISGKTAPNPENEEEMGLEVQEALPLPSLIGVRWVPDSDCEQCTACSAQFTLVRRRHHCRNCGRIFCSRCSANSLPLPELGYDRKVRVCNLCFLYKINPFSPCTGQSNSSQNHSVIAFNSAVTSTAVVLNQVDHERSQDGSQSNESPTATTATTI
What is the function of this protein?
Negative regulator of epidermal growth factor receptor (EGFR) signaling.
What are the official names of this protein?
Lateral signaling target protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the lst-2 family.
Protein: RL2_METMA
Sequence: MGKRLISQNRGRGTPTYRAPSHKYKADLRHPRVDENTSLQGEVIDIEHDPARSAPIAKVAFENGEELFLLASEGVAVGNIIECGDDAEVKPGNIVPIGNVPEGFFICNIESKPNDGGKFVRSSGVYATVVTHEPTRTAVSMPSGNIKWLNPKCRAVVGIVAGGGRVDRPWLKAGKKYHKMKTRAAKYPRVSAVAMNPRDHPFGGGAWKHPGKPTTVSRNAPPGRKVGLIAARRTGMKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: GCH4_PSEMY
Sequence: MNEQLLPDIAAQATHHDLPLHWVGMAGIALPIQLAGQALNASVDIGVSLDDAGARGIHMSRLYLALQGLAGKPLTLAALQHLLDDCLSSHHELSDSASLTVRGALPLQRPALVSQLSGWKHYPFEIHARQDGRGLHMELQVELDYSSTCPCSAALARQLIQQRFAESFAQQPLNYLDVLDWLGSTQGIVATPHSQRSTATLQLRLAADCIDLPLLALLEAAERALGTPVQTAVKRADEQAFALANGQNLMFCEDAARRLHRALRQLPQASAFRVRVVHAESLHAHDAVAESRWNWS
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: ATPG_EHRRW
Sequence: MANLKALFLRMKSVKSIQKTTKVMQMISAAKLRQVQQRLNNARMHMLELSKIIDTNVVTKNNECTGPHNKKDILLVIMSSDRGLCGNFNNMIVKFAKSYIEELESCGKNVKLLFFGKVAYNMMCSQYSSKILDVFSNIQSITDFLSFKLFLYGSGVDFNQFIGVMVLFNKFYTTILQKPTVEQLMPCNIDISVSLKEYYKYEPAYLNVLSTMSLSYILNLMYIAFLENCASEHSSRVIAMESANNNTKEMLSKLVLQYNRSRQAAITTDLIEVISGFESLGNQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GLO2_XYLFA
Sequence: MRLTPLPAFDNNYIWTLIAPDGRAIIVDPGQALPILEAHSKGLIPTAILLTHHHADHIGGVPELLERWPTLPIYAPHDTRIALNYHRIGEGDSLNILGLRFQVIHTPGHTHSHLTFIGNDLLFCGDTLFSLGCGQIFEGTPTQMLASLQRLAALPIQTRVCCGHEYTLSNAAFALHVDPTNTALQKRRQQANAMRLANLPTLPISLESELNTNPFLRTAAPTIHAATATHLQRTPIDEVEVFATLRHWKNNFPIKNIP
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: UVSE_NOSS1
Sequence: MVTIDNSMTATQLNDLPQTAQLRKNAQPELGLVCITFDKKVRFRTMTRTRYLKLSLAQRESSLREIYLHNLQCLHDALTFCQENNLRLYRISSALFPLSDMEDQIGSNILEEISTDLGKIGERSQALNIRMVLHPDQYVVLSSDSPEIVQTSIKILERHARTFDLLGLPRSPWSLMNIHGGKSQRSEQLIKVISNLPENIKSRLTLENDEYAYSTEEIFNVCQKAQIPMVFDAHHQICHENLDSYDHPSVAAMFYAARETWTNPEWQLVHISNGEQAFNDRKHSNLITNMPNIYRQAPWIEVEAKHKEVAIAHLRSWWLMGQ
What is the function of this protein?
Component in a DNA repair pathway.  Removal of UV LIGHT damaged nucleotides.  Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion (By similarity).
What are the official names of this protein?
UV DNA damage endonuclease, UV-endonuclease, UVED.
What is the protein family that this protein belongs to?
Belongs to the uve1/UvsE family.
Protein: DSBB_HERAR
Sequence: MKNSRPVLFAVALASLLLLAVALYLQHVENMLPCPLCVIQRYAFAAIALICLVTAFRTEVTARIGAALAALASLAGAGVAGWHIYIKAHPTVSCGIDPLETSLNTIPTAKLLPFLLQADGLCTTEYAPIMGLSIPQWALVWFIVIALFLLHTAFRKKS
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYW_TROWT
Sequence: MTSSAIRINKKPVVLSGIQPSSGMLHLGNYLGALKSFGRMQDDYTTYFMLANLHSMTFPQNPEVLRENTIRIAAQCIAAGIDPAKSIVFLQSDVYQHNQLAWVLGNVCIFGEAARMTQFKDKSGKQGNISTGLFTYPILMASDILLYDSAFVPVGADQKQHLELTRTLARRFNAQYGQTFLVPQPFECSIRIYDLQDPAVKMSKSSATESGTIFLLDSPDKIVKKIMRSVTDSEDVIGYDRETKPGVSNLVVMYSCLTDCTIEQTVNIYSGKKYSVLKKDLSDILVEVCTTIATRTNELLDDKNYIRKILVTASEQARGVAQKTIDRVYEKLGVY
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPTD_CUPPJ
Sequence: MTEQRRSPNKRANKPPALSGLSSRTGRLPASALRPLVLAMAGLSVGAHAQMSSSAVPDIDQTESVVETAPEVPLAPPVSGELVPRLAEPAKTTQPGESPPAFVSGDRLTGYNERGVVLEGNAELRRGGAVVKGDKLTYDQDTDEAFAHGNARVSRGGALAVGPEARMKVEANEGYMLSPDYYFQQTGGTGKAERIDFIDKDRSVIKRATYTTCSPDNADWYFSARQLDLDSDREVGVAYGGVLHFFDVPIAGAPVFSFPLTDERRSGFLSPLFGYGSKSGLDVTLPYYFNIAPNRDLTLYPRIMTSRGFMLGGDYRYIGQGYSGRLRAEILPDDRQTNSNRWSYSFQHTQNLAKGLNAYLNLNRVSDDRYPDDLTRTVAQSTQRQYIQEGGVTYNWQDFTVLARVQKFQTLLPSGPSYEREPQLNGKYIRYDLGGFDVQVEADYTRFRIPLTSTGFQQPQGERMFVQPTISYPIVRPGWYATPKVIFNATQYQMEPQSNTPTAQNNFSRTVPTFSFDSGMTFERDAPTMSRVFGVNYLQTLEPRLFYVYTPFRDQSQFPLFDTVQSDFGYGQIFSENPFTGYDRVADNNKLTAGLTTRLIEADTGIERFRGTIAQRYDFSGQRVQINGTLPDPKAGSSDLLAATTIQLFRGYYLDAGIQYNPDSEHINYSNLAFAWRPEPRKLLNVGYRYRRATSVTDNTAIDQFEISGQWPITQRAYGIGRFAFDRNANQMVDALAGLEYAADCWVGRVVYQRYRNTTQGYTGRIFLQVEFRGLSKIGSNPLDILRLNVPGYEPVTAKPVPTTQFDHYE
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: RL25_SALPK
Sequence: MFTINAEVRKEQGKGASRRLRAANKFPAIIYGGSEAPIAIELDHDQVMNMQAKAEFYSEVLTLVVDGKEVKVKAQAVQRHAYKPKLTHIDFVRA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: ADDB_STRPZ
Sequence: MKLIYTEMSYSMTEILVNEARKAADQGYRVFYIAPNSLSFEKEREVLTLLPERGTFSIIVTRFVQMSRYFTVESSPSKQHLDDTTLAMIFYRALMQLKPEDLPSYGRLQNNSVFIEQLVELYKELKNAQLSVHDLTGLDHPQKQEDLIKIIELAETIMIQQDYNQDSPLQSFARAIKLGLLNNQLSKTVVVIDGFSRFSAEEDYLLSLLNNNCQEVIIGSYVSQKAYQKSFIKGNIYEASLHFLQDLAQKYHIKPVFATSNQVFKPAFSRLTQLFEATHDFSQVDWQLQKNDLDHFSLWQCHHQKEEIEHVAKSIRQKLYEGYRYKDILVLLGDMDAYQLQIGPIFDKFEIPYYLGKAEPMAAHPLVQFIESLERSQRYNWRREDILNMLKSGLFGCFDDSDIDRFEEYTQFADIKGFTKFSKPFTINSSRQYPLDFLNEMRQDIVLPLQELFKSQKQLGASLVDKLILFLKKIRLAENMQGLAQSQLEVEKNEEVWKRFTDILTSFHHIFGQEKLRLSDCLALIKTGMKSAQYRVVPATLDVVTIKSYDLVQPHSKPFVYAIGLTQSHFPKQIHHSGLLSDQERARINEIRNYRHFDIASAENSKKNHQTALSLFNAATKELVLSVPTVINETFDDLSPYLKELINFGLPLLDKGKNYLSYDNSDIANYKALLSQIIAINRQDLIEMADQDKMFWTGVLRYLRKQLRKQQLELPTSDYRLSTKPLSKEVIEVCFPKGIPLKLSATALTVFYNNQYNYFLKYVLNLNKTESIHPDSRIHGQYLHRVFERLMKDHTQEPFDNKLKQAIYHTNQESFFQQVYQDNAEAEYSLAILEDIVRSTAPILQLNQNIQVIDQEKNFQLDMGNEILVHGIIDRIDQLSDGSLGIVDYKSSANQFDIGTFYNGLSPQLVTYLAALKQIAPHDINQLFGAMYLHLQDPKLDLVTFKQIDNTLVESIYKALTYKGIFSEVEKEHLSTGAYQTKNALYSNDELETLLNYNKYLYLKAAKHIKKGHFLINPYTSDGKTVQGDQLKAITRFEADLDMGQARRLVTLPAKEKKECFLTLMRKESHL
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: EFP_NEIMA
Sequence: MKTAQELRAGNVFMVGNDPMVVQKTEYIKGGRSSAKVSMKLKNLLTGAASETIYKADDKFDVVILSRKNCTYSYFADPMYVFMDEEFNQYEIEADNIGDALKFIVDGMEDQCEVTFYEGNPISVELPTIIVREVEYTEPAVKGDTSGKVMKTARLVGGTEIQVMSYIENGDKIEIDTRTGEFRKRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSD_XYLFA
Sequence: MDSSSFSFSHLDRLEAESIHILREVVAEFRNPVLLYSVGKDSSVLLHLLLKAFSPAPPPIPLLHVDTRWKFREMITFRDRRVAETGVQLRVHINPEGVAQEINPITHGAAVHTDVMKTQGLRQALEQGQFDAAIGGARRDEEKSRAKERVFSFRNAHHRWDPKNQRPELWNVYNARIHPGESVRVFPLSNWTELDVWLYIYREKIPVVPLYFAAPRPVVERDGMLILVDDERLPLRPGEVSKLLWVRFRTLGCYPLTGAVESRAATLEDIIAEMLLTPFSERQGRLIDYVPGASMESKKIEGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: ISPG_BURPS
Sequence: MFGGHAPRRVSHAVDVRWGGTLVTIGGAAPVRVQSMTNTDTADAIGTAIQVKELANAGSELVRITVNTPEAAAAVPAIREQLDRMGVTVPLVGDFHYNGHLLLRDYPDCAQALSKYRINPGNVGQGAKRDSQFAQMIEAAIKYDKPVRIGVNWGSLDQDLLARMMDENGARAEPWEAQSVMYEALIQSAIGSAERAVELGLGRDKIVLSCKVSGVQDLVAVYRELSRRCGFALHLGLTEAGMGSKGIVASTAAIGLLLQEGIGDTIRISLTPEPGAPRTGEVVVGQEILQTMGLRSFAPMVVACPGCGRTTSTLFQELALRIQTYLREQMPVWRSEYPGVEKMNVAVMGCIVNGPGESKHANIGISLPGSGENPAAPVFVDGEKVKTLRGEHIAEEFQQIVSDYVARTYGRAAAQN
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: M2_I79A6
Sequence: MSLLTEVETPTRNGWECKCSDSSDPLVIAASIIGILHLILWILDRLFFKFIYRRLKYGLKRGPSTEGVPESMREEYRQEQQNAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: Y655_MYCPN
Sequence: MSNNNKYFTITKKQYKKMRRNKIELLFNVKVLKKKNGRQKFKILHEVENKPKIPIKIIEDQPESPKPLKPPKPPKPPKGPDNPEEPDSPEEPKETDQPGGPDNPNAGNKKMPTPEEYVTRKEFNEFKDSNNQRLTKIENKVDKLEVKVDKLAEIVQTQGEEIKELKVEQKAQSETLQLILKTLQKMNDRLDRMETRLDKIDSPK
What are the official names of this protein?
UPF0134 protein MPN_655.
What is the protein family that this protein belongs to?
Belongs to the UPF0134 family.