PharMolix/UniProtQA huggingface dataset:
Protein: SELA_PASMU
Sequence: MSLYSSLPSIDKLLKTPEGARLSHEFGHTAVVNICRQLIEQGREYIKNENKLLPVFQDISDTLREIELQLHAQSQVKIQSVHNLTGTILHTNLGRALWSDAAQHAALTSMSHNVALEYDLEEGKRSHRDHYISDLLCQLTGAEAACIVNNNAAAVLLMLATFAQGKEVIISRGELIEIGGAFRIPDIMQQAGCKLVEVGTTNRTHLSDYRHAINENTAFLMKVHSSNYQICGFTKSVTEAELVTLAREFNLPVMTDLGSGALVDLAQYGLPKEPTVQEKWAQGVELISFSGDKLLGGPQAGIIVGKKAWIDRLQTHPLKRALRCDKVILAGLEATLRLYLQPEKLSQHLTTLRLLTQPVEALHEQAEQLQSVLLTKLTTDYSVAITNSVAQIGSGSQPMATIPSVAVTISTEKAGKLTALLQRFKALPQPIICRVEKEKIWLDLRGLADIDSLLKTIMQL
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCM5_DICDI
Sequence: MSGFDEGNVTVSGGGGKGGFKKNNGFVEDTSVRDLFKRFINEWKDQDNVFIYKEQLRQHYNLGWHYIEVSIDHLTDFNQELSGRFISSPNELMPSFEDAIKDIIKEMNYNKEQVDEDIQILFKSSANPEPIRYLRAGLISKLVKVQGIVISASRTQPKPSTMVVKCKNCQHTQTLHIRPGIVSSVLPQQCERGSNDAGKPCPNNPYVVLSDQSTFVNQQILKLQESPETIPTGEMPRHIILSLDKSLADKITPGTRIKVLGVLGIFEGGGKRREIAGGTIRTNYLRVLGITSDNAGRDSMHFTPSEEQSFKVFSRRQDLRNIIASSIAPSIYGHEDIKRAISCQLFGGSSKKLPDKMRLRGDINLLLLGDPGTAKSQLLKFVEKVAPISVYTSGKGSSAAGLTASVIREPSTGEYYLEGGAMVVADGGVVCIDEFDKMNVDDRVAIHEAMEQQTISIAKAGITTILNSRTSVLAAANPVYGRYNDAADDNINFQSTILSRFDLIFIVKDPKNEKRDFIISKHVINIHEKSSRSGGSGSVGNNTYDLSNTVVDDSHIGENEVTIQYLKKYIAYARSRISPRLSEDAVTTLKNHYVSVRAKSKEQEMINNGSYGGGGSKNSVETERKKRKNAIPITVRQLEAIIRISESLAKMSLSPIATNEHAKEAIRLFDISTFDAITTNNTVNETLTPERLENIRTAEKYLKDRVPIGSSIRIKDVRFQLSRSGLDHFTILKAVDILVGRDEFEFRNQKRTLFRKQ
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
What are the official names of this protein?
DNA replication licensing factor mcm5.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: RS3_HELPS
Sequence: MGQKVNPVGLRLGINRNWTSRWFPSARTAPSNIDEDNKIRKFLKKELYYAGVSEIVIERAAKKLRVTVVAARPGLIIGKKGVDIEKVKEGLKTLIKKEVSINIKEVKRPQADAQLAAENVATQLEKRVAFRRAMKKVMQAALKSGAKGIKVRVSGRLAGAEIARTEWYMEGRVPLHTLRAKIDYGFAEAMTVYGIIGVKVWIFKGEVLQKGIQFEKKEEAKEEREPRRSRRGRQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: HOA_GEOSE
Sequence: MAKKRDVWITEVALRDGSHAVAHQYTVEQVVKIAKALDEANVPYIEVAHGDGLAGSSLQYGLSRTNELELIEAAVSVCKQSKIAVLLLPGIGTMKDLQQVAGLGAKMARIATHVTEADVSAQHIGLAKELGMETVGFLMMAHMAPVEKLVEQAKLMESYGADAVYVVDSAGALLPHEVRDRIRALKQHVGVEIGFHGHNNLSLAMANSLVAIEEGATRIDGSVRCLGAGAGNTQTEVLVAVLDRLGVKTGIDLYKMMDLAEEIVAPMLPAPQEITRDSLVLGYAGVYSSFLLHARRIAEKLGMDARDILVELGKRKVVGGQEDMIVDVAVEMAKKRAESLVQ
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase, HOA, 4-hydroxy-2-keto-pentanoic acid aldolase, 4-hydroxy-2-oxopentanoate aldolase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: FPG_ROSDO
Sequence: MPELPEVETVRRGLTPAMEGVVIARADVNRPDLRWPFPADMAARLTGKRVERLRRRSKYILMDLDSGETLLVHLGMSGRMLVSGDPLGQFVHSHPAPEKHDHVVFHMANNARITFNDPRRFGAMDLMETASADTHKLLSVLGPEPLGNDFHESHLIEAFKNRNSPVKSVLLDQRIVSGLGNIYVCEALFRAKIHPIRKAGKISGARVATLVPIIREVLAEAIEAGGSSLRDFKQADGELGYFQHSFDVYGREGAPCKGEGCTGQIKRIVQSGRSSFYCAQCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RS20_PSEA6
Sequence: MANIKSAKKRALQSERRRQHNASRRSMTRTSLKKVLAAIASGDKASAQAAFAAATPLIDRMATKGLIHKNKAARHKSRLSAQIKALA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: CHS2_CANAX
Sequence: MSYNNPNNSNSHLRPHAYNNSRRDDSDGDESSIEFLNQRSNTPLTQGTYNYHNTSTNSLNFQQPEPIYRNQTRTSLSDSYYDHPIFDTSQTQIQPPHDNPFTESYEMTDTSYQGNDHHYRTGQPNHLMNPTYNQAFIPHVYDEEDNDEQEYDQRIQYNQFQGDHFDLAAISYADDESQSQLDYVPTERVIPEGEEEEEEGETSFEKEPGSETISGPFGEERSFEEPPPQQEVRSKKLTRATGLNGHLVLDCPVADELLSKFPDYNPAEKSGGLSREFAFMRYTAVTCGPSNFYRDAYILRPVHYPIPRQTELMIVITMYNEDDILLGRTLKGVFKNIKYLESKARSSTWGKDSWKKIVVCIVSDGRTKINERAQALLAGLGVYQEGLAKSRVDDKKVQAHMFEYTTRVGISKVTDDVVKLTTEKVVPVQMLFCLKETNAKKINSHRWCFQAIGQVLDPKIVVLLDCGTQPSGRSLYELWKEFDRDHRVAGACGEITTSLKKRQMITNPLVYGQNFEYKISNILDKPTESSFGFISVLPGAFSAYRFIALQNDINGIGPLEKYFKGEFLHSSGELDPNDDEFQMKHLMLKEEAGIFTSNMYLAEDRILCFELVAKRGCNWLLRYCKSARAETDVPEGLAEFILQRRRWLNGSFFAAIYSLVHFYKVWTSSHSFGRKIFLHIEFFYQLINLIVSWFSIGSYFLVFRILTTSLGDKALGFAPGKILSVIFLWLYLASIVTTFVLSFGNKPKGTEKFYVTIVIFFAILMAYMIFAAIFMAVHSIQDIYRSGTRITVSLFFQNSEFRDLVVATSSTYALYFLASFLYFEPWHMFTSFVQYILLSPSYVNVLNIYAFCNIDDISWGTKGEVGGKSLGEAKLREDGTFDVSVPISKEQINQSYLDQLEKIRDPAPPEEKVLVTNTEDYYAFIRSMTVLVWMFTNFVVIALVLETGGFNQFVEATDLANLKSNRAAVFLTVILWTVAFMALFRFIGCIYYLITRLGREIKASEHATK
What is the function of this protein?
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
What are the official names of this protein?
Chitin synthase 2, Chitin-UDP acetyl-glucosaminyl transferase 2.
What is the protein family that this protein belongs to?
Belongs to the chitin synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RK16_ORYSI
Sequence: MLSPKRTRFRKQHRGRMKGKSYRGNCICFGRYALQALEPTWITARQIEAGRRAMTRYARRGGKIWVRIFPDKPVTIRPTETRMGSGKGSPEYWVAVVKPGRILYEMGGVSETVARVAISIAASKMPIRSQFLRLEI
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LEXA_YERPB
Sequence: MKALTTRQQEVYDLVRDHLAQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLMEEEEGLPLIGRVAAGEPLLAQQHIEGHYKVDPSLFKPGADFLLRVNGMSMRDIGILDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNIVHLLPENSEFQPIVVDLREQSFTIEGLAVGVIRNGDWI
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: LEA41_ARATH
Sequence: MAARSLSGAVKSLCSAASGSLSCSIVLRRSYVATSQNVTAAGLSKGGSTRVMVGKMEQRGLDQEAESAWGPDPVTGYYRPSNRAAEIDPAELRELLLKNKAKSF
What are the official names of this protein?
Late embryogenis abundant protein 41, Protein DROUGHT-INDUCED 21, AtDI21.
What is the protein family that this protein belongs to?
Belongs to the LEA type 3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NS6_SARS
Sequence: MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDYP
What is the function of this protein?
Disrupts bidirectional nucleocytoplasmic transport by interacting with host RAE1-NUP98 complex (PubMed:33849972).  Disrupts cell nuclear import complex formation also by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:17596301).  Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (PubMed:17596301).  Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:17596301).
What are the official names of this protein?
ORF6 protein, ORF6, Accessory protein 6, Non-structural protein 6, ns6, Protein X3.
What is the protein family that this protein belongs to?
Belongs to the coronaviruses accessory protein 6 family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane. Host Golgi apparatus membrane. Host cytoplasm. Note=Localizes to virus- induced vesicular structures called double membrane vesicles.
Protein: MTND_YERPP
Sequence: MSGLTIFSDQQPEKPLWQSHNAEEIQQQLTAIGVRFERWQADCELGENPQPEAVIAAYQHEIDRLVAENGYKSWDVISMRPDNPQREALREKFLSEHTHGEDEVRFFVEGSGLFCLHLNEKVYQILCEKNDLLSVPADIPHWFDMGSAPNFTAIRVFDNPEGWIARSTGDNIADGYPRLA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: ACHA9_RAT
Sequence: MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD
What is the function of this protein?
Ionotropic receptor with a probable role in the modulation of auditory stimuli.  Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane.  The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane.  In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing.  This may protect against acoustic trauma.  May also regulate keratinocyte adhesion.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-9, Nicotinic acetylcholine receptor subunit alpha-9, NACHR alpha-9.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: HSLU_ECO57
Sequence: MSEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQTEQQQEPSAARQAFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDAMKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNESTENIGARRLHTVLERLMEEISYDASDLSGQNITIDADYVSKHLDALVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Heat shock protein HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_SALPB
Sequence: MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFREAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQENGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQKLALA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: R1A3_SOLDE
Sequence: MKTVIARTSSKLARTPRMNEEIVGFEDVIENLRKKLLSETKGQDVISIHGMPGLGKTTLANRLYSDRSVVSQFDICAQCCVSQVYSYKDLLLSLLRDAIGDESGSRELPDNELADMLRKTLLPRRYLILVDDVWDNSAWDDLRGCFPDVNNRSRIILTTRHHEVAKYASVHSDPLHLRMFYEDESWKLLEKKVFGEQSCSPLLKDVGLRIAKLCGKLPLSIVFVAGTLSEMEKEVECWEQMANNLGGPKLSSFLEDRVIDISRLIRLWISESFIKSSEGRSLEDIAEGYLENLIGRNLVMVTQRADSDGMVKACRLHDVLLDFCKKRAAEENFLLCIKRDQSTKAVISHKQQAHLAFSKMDNLVEWSASSSLVGSVIFKSYDPYFARCPLSSHAFALSHILINFKFLKVLDLEHQVVIDFNPTEHFYLRYLSAHIDQNSIPSSISNLWNLETLILKRTPAGRLNTLLLPSTIWDMVKLRHLHIPNFRAESEDALLENSAKLYDLETLSTTYFSSVEKAELMLRKTPNLRKLICEVQFLEYPNQYHVLNFPVRLEMLKLYRFNNSKVIPFYISAPNLKYLKLSGFYLDSHYLSETADHLKHLEVLKLYRVEFGDHGEWKVSNGMFPQLKILKLNYVCLMKWIVADDAFPNLEQLVLRGCKDLMEIPFCFMDILSLKYIELDNCNKSVVKSAKDIEEAQVEDNQNTNFKLVIIKKMILQFDISHDKEIDNAFKRLASLPGVDSISIDMIEKKLTVGGDMNANEVRLVVGKLIDSGML
What is the function of this protein?
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1.  Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein.  That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
What are the official names of this protein?
Putative late blight resistance protein homolog R1A-3.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: ASSY_METTH
Sequence: MKVIAVDKVVLAFSGGLDTSVCIKLLEEKYNMEVITACVDVGQPRDEIERPAMVAKELGNYRHYTVDARREFAEDYIFPAIKANAVYEGYPLSTALARPLIAKKIVEVAEKEGASAIAHGCTGKGNDQFRFEAVIRSTTDLDVIAPIRDLNLTRTEEMEYARSCGIPLPSDKLYSIDENLWGRAIEGDILEDPMVEPPEDAFEWTKPIHETPEDPEVIEIGFHGGVPVALNGEELEPVELIGLANEVAGKHGIGRVDIMEDRIIGMKSREIYETPAAFLLLEAHRGLEQLTLTRSELRFADIISSTYAELVYSGLWHDPLREDLDMAVNHMQRRVTGTVRVKLHRGSMRVIGRESPYSLYSEEIVSFEDKTLDQREMAGMVKNYALQAAIYSRVCRKEN
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SQS3_PANGI
Sequence: MGSLGAILKHPDDFYPLLKLKIAARHAEKQIPSEPHWAFCYSMLHKVSRSFGLVIQQLGPQLRDAVCIFYLVLRALDTVEDDTSISTEVKVPIVMAFHCHIYDNDWHFSCGTKEYKVLMDEFHHVSNAFLDLGSSYKEAIEDITMRMGAGMAKFICKEVETIDDYDEYCHYVAGLVGLGLSKLFHASGAEDLATDSLSNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPRQIWSKYVDKLEDLKYEENSGKAVQCLNDMVTNALLHVEDCLKYMSDLRDPAIFRFCAIPQIMAIGTLALCYNNIQVFRGVVKMRRGLTAKVIDRTNTMSDVYGTFFDFSCMLKSKVDNNDPNATKTLSRLEAIQKICKNSGALTTKRKSYIIENESGYNSTLIIILFIILAILYAYLSSNLPNSL
What is the function of this protein?
Component of the triterpene saponins (e. g.  ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:29378087).  Catalyzes the biosynthesis of squalene (By similarity).
What are the official names of this protein?
Squalene synthase 3, PgSS3, SQS 3, FPP:FPP farnesyltransferase SS3, Farnesyl-diphosphate farnesyltransferase SS3.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYUA_LAGLA
Sequence: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTSVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDHSGKSEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
What is the function of this protein?
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity).  Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity).  Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity).  Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity).  This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity).  Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
What are the official names of this protein?
Alpha-synuclein.
What is the protein family that this protein belongs to?
Belongs to the synuclein family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane. Nucleus. Synapse. Secreted. Cell projection, axon. Note=Membrane-bound in dopaminergic neurons (By similarity). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity).
Protein: SHE2_ASHGO
Sequence: MPIPDMSSQYPHQQEDMSQEEEPRGRKPQSMVDQEKQDYLDFIVPRLQITGKILQLTEEVIQEQANYISRYIDFLNKYINYQRKVSTLRFERATLIKYVKKLRFLNDFLYTYNADVNMITEPLQKLVRPLGSFFIRYLEIIDLLNYYLTQSLRNETISKTLNQDLVLSQECIAMADKTYRVYVKFVQWFIESSSSVTTGDLTMEIVQFTRKCAVEDGIDLGETDDVLLQEVQLVTSSEEFEDLLEKWQQVLHFQCADLDDTFNDNIRHWSELFDKKKEK
What is the function of this protein?
RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease.  Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell (By similarity).
What are the official names of this protein?
SWI5-dependent HO expression protein 2.
What is the protein family that this protein belongs to?
Belongs to the SHE2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm and is exported in an mRNA-dependent manner. The presence in the nucleus is essential for PUF6 and LOC1 to bind the ASH1 mRNA.
Protein: RL20_SYNS3
Sequence: MARVKRGNVARKRRNKILRLARGFRGSNGTLFRTANQRVMKALCNAYRDRRRRKRDFRRLWIARINAAARMNGVSYSRLIGGLKKADVRINRKMLAQMAVVDPASFANVVNATQG
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CDPF1_MOUSE
Sequence: MASETEPRPLGTFECQLCALSAPYSYVGQKPPDTQAVVLLEESYIMKDPFSSDKARFLVLGSRCSVCSRLVCVGPDCSLFYSKRVCLPCVQENMSAFPQEIQQDVEKRKSTSKKHSNRP
What are the official names of this protein?
Cysteine-rich DPF motif domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the CDPF1 family.
Protein: EBPS_STAAS
Sequence: MSNNFKDDFEKNRQSIDTNSHQDHTEDVEKDQSELEHQDTIENTEQQFPPRNAQRRKRRRDLATNHNKQVHNESQTSEDNVQNEAGTIDDRQVESSHSTESQEPSHQDSTPQHEEEYYNKNAFAMDKSHPEPIEDNDKHETIKEAENNTEHSTVSDKSEAEQSQQPKPYFATGANQANTSKDKHDDVTVKQDKDESKDHHSGKKGAAIGAGTAGVAGAAGAMGVSKAKKHSNDAQNKSNSDKSNNSTEDKVSQDKSKDHHNGKKGAAIGAGTAGLAGGAASKSASAASKPHASNNASQNHDEHDNHDRDKERKKGGMAKVLLPLIAAVLIIGALAIFGGMALNNHNNGTKENKIANTNKNNADESKDKDTSKDASKDKSKSTDSDKSKEDQDKATKDESDNDQNNANQANNQAQNNQNQQQANQNQQQQQQRQGGGQRHTVNGQENLYRIAIQYYGSGSPENVEKIRRANGLSGNNIRNGQQIVIP
What is the function of this protein?
Promotes binding of soluble elastin peptides and tropoelastin to S. aureus cells although it is not able to promote bacterial adherence to immobilized elastin and, therefore, is not a microbial surface component recognizing adhesive matrix molecule (MSCRAMM).
What are the official names of this protein?
Elastin-binding protein EbpS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PAQR6_HUMAN
Sequence: MLSLKLPQLLQVHQVPRVFWEDGIMSGYRRPTSSALDCVLSSFQMTNETVNIWTHFLPTWYFLWRLLALAGGPGFRAEPYHWPLLVFLLPACLYPFASCCAHTFSSMSPRMRHICYFLDYGALSLYSLGCAFPYAAYSMPASWLHGHLHQFFVPAAALNSFLCTGLSCYSRFLELESPGLSKVLRTGAFAYPFLFDNLPLFYRLGLCWGRGHGCGQEALSTSHGYHLFCALLTGFLFASHLPERLAPGRFDYIGHSHQLFHICAVLGTHFQLEAVLADMGSRRAWLATQEPALGLAGTVATLVLAAAGNLLIIAAFTATLLRAPSTCPLLQGGPLEGGTQAKQQ
What is the function of this protein?
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870).  Seems to act through a G(s) mediated pathway (PubMed:23161870).  Involved in neurosteroid inhibition of apoptosis (PubMed:23161870).  May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432).  Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870).
What are the official names of this protein?
Membrane progestin receptor delta, mPR delta, Membrane progesterone P4 receptor delta, Membrane progesterone receptor delta, Progesterone and adipoQ receptor family member 6, Progestin and adipoQ receptor family member 6.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIMP_SHEHH
Sequence: MATLERKLVEMLKAPVEALGHQLWGLEYIQAGKHSILRLYIDNEKGIFIEDCAEASRQVSAVLDVEDPITSEYTLEVSSPGVERLLFTAEQYKAYIGETVKVQLTMPVAGSRNLKGTVTGVDGQMLNLSVDGNELIVALDNIRKGNLIAKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.