PharMolix/UniProtQA huggingface dataset:
Protein: FAL1_ASPTN
Sequence: MADGIDRRADDRMEFNTSKEVTVAPTFEDMHLKESLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFAISILQVIDTVVRESQALVLSPTRELATQIQSVIMALGDYMNVQCHACIGGTNIGEDIRKLDYGQHVVSGTPGRVADMIRRRHLRTRHIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRVLVKRDELTLEGIKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGEMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPTNRENYIHRIGRSGRFGRKGVAINFVTSDDVRILRDIELYYSTQIDEMPMNVADLLS
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase fal1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RPOC1_PINKO
Sequence: MIEQNKHQQLRIGLASPEQICAWSEKILPNGEIVGQVTKPYTLHYETNKPERDGSFCERIFGPIKSRVCACGNSPGIGNEKIDSKFCTQCGVEFVDSRIRRYQMGYIKLACPVVHVWYLKRLPSYIANLLAKTRKELEGPVYCDLFLARPIAKKPTLLRSRGTFNYEIQSWKDIIPHYLSARPHYLFARGSGTFKEREIATGGDAIGEQLTGLDLQMIIDRSHMEWKNLVELKWNRLEENQESTVDRWEDEKIRRRKDFLVGRIKLAKHFLRTNIEPKWMVLCLLPVLPPEPRPIVQLGEGGLITSSDLNELYRRVINRNNTLTNLLARSGSESFVICQKKLIQEAVDALLDNGICGQPMRDSHDRPYKSFSDVIEGKEGRFRENLLGKRVDYSGRSVIVVGPFLSLYQCGLPSEIAIELFQAFVIRSLIGRHIAPNLRAAKSMIRDKGPIVWEVLQEVMQGHPVLLNRAPTLHKLGIQAFQPILVEGRAIRLHPSVCGGFNADFDGDQMAVHVPLSLEARAEARLLMFSETNLLSPAIGDPISIPTQDMLLGLYISTVENSQGIYGNRYHPYHSEKKSFSCKKPSFYSYDDVLRAYRQKRIDLYSPLWLRWGELDLRIITSVNQEAPIEVQYESLGTFHEIHEHYRIRKGRMGEILNIYIRTTVGRTRFNREMEEAIQGFACFEHPKKSLPALRI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PARP2_ARATH
Sequence: MANKLKVDELRLKLAERGLSTTGVKAVLVERLEEAIAEDTKKEESKSKRKRNSSNDTYESNKLIAIGEFRGMIVKELREEAIKRGLDTTGTKKDLLERLCNDANNVSNAPVKSSNGTDEAEDDNNGFEEEKKEEKIVTATKKGAAVLDQWIPDEIKSQYHVLQRGDDVYDAILNQTNVRDNNNKFFVLQVLESDSKKTYMVYTRWGRVGVKGQSKLDGPYDSWDRAIEIFTNKFNDKTKNYWSDRKEFIPHPKSYTWLEMDYGKEENDSPVNNDIPSSSSEVKPEQSKLDTRVAKFISLICNVSMMAQHMMEIGYNANKLPLGKISKSTISKGYEVLKRISEVIDRYDRTRLEELSGEFYTVIPHDFGFKKMSQFVIDTPQKLKQKIEMVEALGEIELATKLLSVDPGLQDDPLYYHYQQLNCGLTPVGNDSEEFSMVANYMENTHAKTHSGYTVEIAQLFRASRAVEADRFQQFSSSKNRMLLWHGSRLTNWAGILSQGLRIAPPEAPVTGYMFGKGVYFADMFSKSANYCYANTGANDGVLLLCEVALGDMNELLYSDYNADNLPPGKLSTKGVGKTAPNPSEAQTLEDGVVVPLGKPVERSCSKGMLLYNEYIVYNVEQIKMRYVIQVKFNYKH
What is the function of this protein?
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.  This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).
What are the official names of this protein?
Poly [ADP-ribose] polymerase 2, PARP-2, NAD(+) ADP-ribosyltransferase 2, ADPRT-2, Poly[ADP-ribose] synthase 2, Protein ADP-ribosyltransferase PARP2.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LZTS3_HUMAN
Sequence: MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSGEGGGGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAWTPSRLERIESTEI
What is the function of this protein?
May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.
What are the official names of this protein?
Leucine zipper putative tumor suppressor 3, ProSAP-interacting protein 1, ProSAPiP1.
What is the protein family that this protein belongs to?
Belongs to the LZTS3 family.
What are the subcellular locations of this protein?
Synapse. Postsynaptic density. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm, cytoskeleton. Note=Rather found at excitatory than inhibitory synapses.
Protein: CAVN1_MOUSE
Sequence: MEDVTLHIVERPYSGFPDASSEGPEPTQGEARATEEPSGTGSDELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSVSKSLKESEALPEKEGDELGEGERPEDDTAAIELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPVERREKLKTSRDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGEVEVLKATEMVEVGPEDDEVGAERGEATDLLRGSSPDVHTLLEITEESDAVLVDKSDSD
What is the function of this protein?
Plays an important role in caveolae formation and organization.  Essential for the formation of caveolae in all tissues (PubMed:18191225, PubMed:18840361, PubMed:18056712, PubMed:30188967).  Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242).  Essential for normal oligomerization of CAV1 (PubMed:23652019).  Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195).  Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:9582279, PubMed:11139612).  The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (PubMed:30188967).
What are the official names of this protein?
Caveolae-associated protein 1, Cav-p60, Cavin-1, Polymerase I and transcript release factor.
What is the protein family that this protein belongs to?
Belongs to the CAVIN family.
What are the subcellular locations of this protein?
Membrane, caveola. Cell membrane. Microsome. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion. Nucleus. Note=Translocates to the cytoplasm from caveolae upon insulin stimulation (By similarity). Colocalizes with CAV1 in lipid rafts in adipocytes (PubMed:18056712). Localizes in the caveolae in a caveolin- dependent manner (PubMed:19546242).
Protein: APHR_MESAU
Sequence: MVKILVLALVFSLAHAQDFAELQGKWYTIVIAADNLEKIEEGGPLRFYFRHIDCYKNCSEMEITFYVITNNQCSKTTVIGYLKGNGTYQTQFEGNNIFQPLYITSDKIFFTNKNMDRAGQETNMIVVAGKGNALTPEENEILVQFAHEKKIPVENILNILATDTCPE
What is the function of this protein?
Acts as an aphrodisiac pheromone, reliably eliciting copulatory behavior from male hamster.
What are the official names of this protein?
Aphrodisin.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DIR24_ARATH
Sequence: MAKALSLTIFLFLLIASNVQSARLLDEVQTQPQLVPQVPEEEDDSPQAVTTTPTPIPLPGPATGGPEPILEFFMHDVLGGSHPSARVVTGIVAQTEVNGIPFSKSSNNIFPVDNAVPLVNANSINNLINPNTAPLLTGLSGSQANTVIQNSNGNSQGSLSSNNLPFVTTGQLPPIAALQQLMFGSITVVDDELTEGHELGSAIIGRAQGFYLASSLDGTSQTLSLTVLLHEDHDHHDTLDDAISFFGVHRTASHASHIAVVGGTGRFEHAKGYAVVETLHNQEDQHVTDGHDTILHFSVYLTYYKA
What is the function of this protein?
Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.
What are the official names of this protein?
Dirigent protein 24, AtDIR24.
What is the protein family that this protein belongs to?
Belongs to the plant dirigent protein family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: TYLM2_STRFR
Sequence: MRRALDDRRRGPHGPEGKPPMRVLLTCIAHNTHYYNLVPVAWALRAAGHEVRVAAQPALTDTITASGLTAVPVGGNESVLEFVTEIGGDPGPYQRGMDFAETCGEPLSYEHALGQQTAMSALCFAPFNCDSTIDDMVALARSWRPDLVLWEPFTYAGPIAAHACGAAHARLLWGPDVILNARAQFRRLAAGQPEERREDPVAEWLGWTLERHGLTAERETVEELIGGQWTLDPTAESLRLPAAGRVVPFRFVPYNGRSVLPDWLLRKPGRPRVCFTLGVSARETYGRDAVPFHELLAGLGDLDAEIVATLDPGQLSGAGEVPRNVRAVDFVPMDALLPTCSAVVHHGGAGTCFTATLNGLPQIVVAALWDAPLKGAQLAEAGAGVSIAPEKLDAATLRAGVVRALEDEDMRRSAGLLRAEMLAEPTPAGLVPQLERLTALHRNGRSRSAPER
What is the function of this protein?
Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone.  Catalyzes the transfer of alpha-D-mycaminosyl from dTDP-alpha-D-mycaminose to the 5-hydroxyl group of tylactone to yield 5-O-mycaminosytylactone.  It can also accept 16-membered tylactone and 12-membered ring macrolide.
What are the official names of this protein?
Tylactone mycaminosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family.
Protein: TO6BL_SCHPO
Sequence: MHRVRSARDGIVLKYHFKEDWDETQNSPIDCIASSRLKFWKRLNFNIYLDPEVSNQNLKLLKTLTLHCDFQSPKKNLTMSKFKAMAVELIHEAFLKHIVSILSKECPLSFQPSYYSKMFNAMSNANIIAGSISRILTRESLDKSFEQSHFQLLMYKKCKLIYTRTLRKNEFDGIHKFPDLEDSKQKLQVADDEENKQYSESSLLDDSQLLCSSPPVDSTEEARTCNVEEDQDEILSVALVTTDTILSSDNFVNDMLSAAD
What is the function of this protein?
Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination (PubMed:10882124).  May be involved primarily in the early steps of meiotic recombination (Probable).
What are the official names of this protein?
Meiotic recombination protein rec6.
What is the protein family that this protein belongs to?
Belongs to the TOP6B-like family.
Protein: ROA0_MOUSE
Sequence: MENSQLCKLFIGGLNVQTSESGLRGHFEAFGTLTDCVVVVNPQTKRSRCFGFVTYSNVEEADAAMAASPHAVDGNTVELKRAVSREDSARPGAHAKVKKLFVGGLKGDVAEGDLIEHFSQFGAVEKAEIIADKQSGKKRGFGFVYFQSHDAADKAAVVKFHPIQGHRVEVKKAVPKEDIHAGGGGARAARGGRGGGRGRGGGGGGGGRDQNGLAKGGGGGGGGYNSYGGYGGYGAYGGGGGGGGSYGGSDYGNGFGGFGSYSQHQSSYGPMKSGGGGGGGGSWGGRSNSGPYRGGYGGGYGGGSF
What is the function of this protein?
mRNA-binding component of ribonucleosomes.  Specifically binds AU-rich element (ARE)-containing mRNAs.  Involved in post-transcriptional regulation of cytokines mRNAs.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein A0, hnRNP A0.
What are the subcellular locations of this protein?
Nucleus. Note=Component of ribonucleosomes.
Protein: GGN1_LIMKU
Sequence: MFTMKKSLLFLFFLGTINLSLCEEERNAEEEKRDGDDEMDVEVQKRFIGPVLKMATSILPTAICKGFKKC
What is the function of this protein?
Has antimicrobial activity against Gram-positive bacteria S. aureus ATCC 2592 (MIC=5. 0 uM), S. aureus ATCC 43300 (MIC=10. 0 uM) and B. subtilis (MIC=20. 0 uM), against Gram-negative bacteria E. coli ML-35P (MIC=50. 0 uM), P. aeruginosa PA01 (MIC=10. 0 uM) and P. aeruginosa ATCC 27853 (MIC=5. 0 uM) and against fungus C. albicans ATCC 2002 (MIC=10. 0 uM).
What are the official names of this protein?
Gaegurin-LK1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y776_RHILO
Sequence: MTAPRKPAAFRIEPEAAPTQETPKARQAELSRKPRGLKTDVALVIPAEVDVFDEPDIVAAEPPPAAAPRKRSLFGSIFFGAIGVLVSLAVGLWTDQLIRDLFARAEWLGWLAAGMAAIAVLALVVILIREFLAIARLAEVEKLQKRALDAIARDDPKAARSVVDELSAFVAAKPETAAGRRALAELRGEIIDGGNLVRLAEAEILGPLDARAKVMILEAAKRVSLVTAVSPRALVDVAYVVFEAGRLIRRLSELYGGRPGTLGFFRLARSVLAHLAVTGSIAVGDSFVQQIVGHGLAARLSAKLGEGVVNGMMTARIGIAAMETARPLPFSAAKRPGLGDFLSALTSFAAKKDTETTGSGK
What are the official names of this protein?
UPF0283 membrane protein mlr0776.
What is the protein family that this protein belongs to?
Belongs to the UPF0283 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NDK_ACICJ
Sequence: MATERTLSIIKPDATRRNLTGRINAKFEEAGLRIVAQKRIRLTKDQAEAFYGVHKERPFFAGLVSFMTSGPVVVQVLEGDDAVARNRAIMGATDPRKAEAGTIRAEFAEDIEANSVHGSDAADTAAQEIAFFFAGVEIVG
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_METPP
Sequence: MAPPVPAPSSDLPNIAPRDKAEILAQALPYIRKFHGKTLVIKYGGNAMTDPALQQDFAEDIVLLKLVGMNPVVVHGGGPQIDEALSRLGKKGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVGLINAVGGKAVGLTGRDGGMIRARKLKMVDKDDPSIEHDVGQVGEITAIDPAVVKALQDDQFIPVVSPIGFGEHNESYNINADMVASKLATVLQAEKLMLLTNTPGVLDKAGKLLTNLSAREIDELFADGTISGGMLPKIAGALDAAKSGVNAVHIIDGRVPHAMLLEILSDQAYGTMIRSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNC2_ALBFT
Sequence: MKISLNGISVQHPSAKPGAVPALREQNLTVRAGEQLAIIGPSGAGKTTLLHLLACALKPSAGSMLLNDQDPWQLSRGALQKLRGALFLAPQVPPLPPRQRVVTAVLAGRLPNESLWASLRSLFYPTDIALAERALAGFDVGDKLFDRVDRLSGGERQRVGLARALVSQASLILVDEPLSALDPTRSQHAIETLTRAAQERGATLVATLHHVEMALAHFPRIVGLRDGQVAFDLPAAEVTPELLQALYAQHLHELTGLANLEADDLPTDPAPVVMHCR
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y898_THENN
Sequence: MKRVVVVTGLSGAGKTTAMGFLEDLGYFCVDNVPGSILEELLKLFMSSDLEKMAIAVDVRSEHFSDPVEAIEKIKKKTNALIVFLEASKEELLRRYALTRRRHPLQRNDVGLEEAIEKERQILLPIKEMADFVIDTTKMTSHQLREILGQSLMNQSGGISVRILSFGFKHGIPMDADFIFDARFLPNPHYVPELSHKTGLDREVEEYFKKYSLVDEFVYKIFEVVNVAVKEYQRSGRRIVTVGIGCTGGRHRSVYIAHKIAEMLKKEGFSVVEKHRDLEKV
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein CTN_0898.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ODPA_BOVIN
Sequence: MRKMLAAVSRVLSGVAQKPASRVLVASRHFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYCNDPPFEVRGANQWIKFKSIS
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SGCB_PONAB
Sequence: MAAAAAAAAAEQQSSNGPVKKSMREKAVERRNVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH
What is the function of this protein?
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
What are the official names of this protein?
Beta-sarcoglycan, Beta-SG.
What is the protein family that this protein belongs to?
Belongs to the sarcoglycan beta/delta/gamma/zeta family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Single- pass type II membrane protein. Cytoplasm, cytoskeleton.
Protein: OST48_ARATH
Sequence: MVNLSRSVALISVFLLPLLSFSFSVDNPTDRRVLVLLDDLSLKSSHSIFFNTLKSRGFDLDFKLAEDSKLALQRYGQYLYDGLIIFAPSTERFGGSLDSKSIADFVDSGRDLILSADTAASDLIRGIATECGVDFDEDSSAMVIDHTSFSVSDVDGDHTLIAADDLVKSDVILGKTKIEAPVLFRGVAHSLNPTNNLVLKVLSASPSAYSANPSSKLSSPPQLTGSSISLVSVMQARNNARVVISGSVQLFSDRLIRSGVQKAGSPNQYEKSGNEQFVTELSKWVFHERGHLKAGNLVHHRVGETDEPAIYRIKDDLEFSVEIYEWSGKSWEPYVANDVQVQFYMMSPYVLKTLSTDKKGLFHTSFKVPDVYGVFQFKVEYEKLGYTTLSLSKQIPVRPYRHNEYERFIPTAYPYYGACFTTMAGFFVFSFVYLYHK
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:15860005).  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity (By similarity).
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Oligosaccharyl transferase 48 kDa subunit, Protein DEFECTIVE GLYCOSYLATION 1.
What is the protein family that this protein belongs to?
Belongs to the DDOST 48 kDa subunit family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RL16_THEMA
Sequence: MLMPRRVKYRKQQRGRMKGKAKGGTFVQFGEWGLKALEPAWITAQQIEACRIAMLRVMKRSGKIWIRIFPDKPYTKKPPESRMGKGKGNVEGWVAVVKPGKILFEVAGVDEETAHEALRYAASKLPIATKIVPRHHIGGEAV
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RUVA_STRGG
Sequence: MIAFVSGPVAALAPTTAVIEVGGIGMAVQCTPHTLADLRVGREARLATSLVVREDSLTLYGFANDDERQVFELLQTASGVGPRLAQAMLATHSPDALRLAVSTGDEKALTAVSGIGKKGAQKLLLELKDRLGEPVGAHIGQQGIGTPVTSGWRDQLQAALIGLGYASREADEAVNAVAPQAEAAVAEGTAPPVPQLLRAALQTLNRAR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RS18_MARMM
Sequence: MSSGNISNLPARRPFMRRRKVCPFSGENAPAIDFKDPKLLLRYMSERGKIVPSRITAVSAKKQRELARAIKRARQLALLPYVVD
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TAZ_DANRE
Sequence: MPLEVTWPFPQCPRLGWRISSRVVMGMVGSYSYLWTKYFNSLMVHNQDVLLNLVDERPQDTPLITVCNHQSCMDDPHIWGVLKFRQLWNLNKMRWTPTASDICFTREFHSSFFSRGKCVPVVRGDGVYQKGMDFLLERLNQGEWIHIFPEGRVNMSGEFMRIKWGIGRLIAECSLHPIILPMWHIGMNDVLPNETPYIPRVGQRITVLVGKPFTVRHLVNALRAENTNPTEMRKTVTDYIQDEFRSLKAQAEALHHRLQNHT
What is the function of this protein?
Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity).  Its role in cellular physiology is to improve mitochondrial performance (By similarity).  CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity).  Catalyzes the transacylacion between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL.  Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations.  Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate.  Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution.  Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor.  CoA-independent, it can reshuffle molecular species within a single phospholipid class.  Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL.  Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane.  Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes.  Essential for the final stage of spermatogenesis, spermatid individualization (By similarity).  Required for the initiation of mitophagy (By similarity).  Required to ensure progression of spermatocytes through meiosis (By similarity).
What are the official names of this protein?
Tafazzin, Taz.
What is the protein family that this protein belongs to?
Belongs to the taffazin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: COXX2_SACEN
Sequence: MTKEFHAVGERSVVTTAVDAPQARHARRPAELLKAYAGLIKPRVIELLLVTTIPAMLLAARGIPSPWLVIATLVGGTMAAGSANALNCVADADIDQVMKRTRARPLVRHTVSNRHALVFGIALGAGSFGWLWATTNLLSAVLAVATILFYVFVYTLVLKRRTAQNIVWGGAAGCMPVVIGWAGVTGRVDWPALVMFGIIFFWTPPHTWSLAMKYRDDYERAGVPMLPVVARPTYVSRQIVVFTWLMVLWTLLLAPATGWLYTAFAIAAGAWFLVLAHRLHAQTRRGEPTKPLKLFHLSNTYLMIVCVALAVDSALSLPVLGWPF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase 2, Heme B farnesyltransferase 2, Heme O synthase 2.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.