PharMolix/UniProtQA huggingface dataset:
Protein: SRP19_PYRFU
Sequence: MGRFVVWPSELDSRLSRKYGRIVPRSIAVESPRVEEIVRAAEELKFKVIRVEEDKLNPRLSGIDEELRTFGMIVLESPYGKSKSLKLIAQKIREFRRRSA
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLM_ECOLC
Sequence: MGKTQPLPILITGGGRRIGLALAWHFINQKQPVIVSYRTHYPAIDGLINAGAQCIQADFSTNDGVMAFADEVLKSTHGLRAILHNASAWMAEKPGAPLADVLACMMQIHVNTPYLLNHALERLLRGHGHAASDIIHFTDYVVERGSDKHIAYAASKAALDNMTRSFARKLAPEVKVNSIAPSLILFNEHDDAEYRQQALNKSLMKTAPGEKEVIDLVDYLLTSCFVTGRSFPLDGGRHLR
What is the function of this protein?
Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin.  Also has lower activity with dihydrofolate.
What are the official names of this protein?
Dihydromonapterin reductase, H(2)-MPt reductase, Dihydrofolate reductase, DHFR.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily.
Protein: ISPH_CLOPS
Sequence: MERNVILAKNAGFCFGVKRAVDEAIKYQKEFGKKIYTLGPLIHNNDVVNYLEDNDIFAIELSDTNSLNKGDVVLIRSHGVKESVIKDLTDKGLIVKNATCPYVTNIQLKVKKCYEQGYKIIIVGDENHPEVIGINGWCNDSAIITNGKTELENIPAKVCVVSQTTEKKETWNKVLNEIVKESKEIVAFNTICSATDVRQKSVQELSKEADLVFVIGGKNSSNTTKLYEICKKECPKSYHIENVKELDESLLEDESVKTIGITAGASTPDWIINEVISKIKEL
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RL9_CHLPN
Sequence: MKQQLLLLEDVDGLGRSGDLITARPGYVRNYLIPKKKAVIAGAGTLRLQAKLKEQRLIQAAADKADSERIAQALKDIVLEFQVRVDPDNNMYGSVTIADIIAEAAKKNIFLVRKNFPHAHYAIKNLGKKNIPLKLKEEVTATLLVEVTSDNEYVTVLAQGKQTEENQEG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ILVX_ECOLI
Sequence: MNNSTKFCFSRFRTGN
What are the official names of this protein?
Uncharacterized protein IlvX.
Protein: RISB_PSECP
Sequence: MSGHGAPDIDLTTLNPAETSQLRLAIVAASWHTQIMDGLLDGALRAAKDAGINEPTVIRVPGSFELPVAAARLAPHFDAVVALGVVIRGGTPHFEYVCQAATSGLTDVSVRTGVPVGFGVLTCDTEQQGLDRAGLPGSKEDKGHEAVTAALATAVVLKQYS
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: LARG2_CHICK
Sequence: MLCSWRVKLKLLLATITLAVLLSWLYLFVGSLEYGRFLLLPPCLGEQPSRDVEREALASQVRRVEEENQQLRMQLGQVQAEGSDGNPQWAASAEDGPPLGGERNNRTACPEQRMVRKCELLHVAIVCAGHNASRDVVTLVKSILFHRKNPLHFHFITDSVAHQILQTLFQSWMVPSIHVSFYNADDLKPEVSWIPNKHYSGIYGLMKLTLTKALPSNLSKVIVLDTDITFATDIAELWAVFGKFSEKQVIGLVENQSDWYLGNLWKNHKPWPALGRGFNTGVILLLLDRLRRLGWEQMWRLTAERELMSMLSTSLADQDIFNAVIKQNPALVYRLPCFWNVQLSDHTRSELCYTEVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCASLPSPPSDQLQQALEELDEDDPCYDFRRQHLTQHRVHLFFLQYEFLALPNPTDVTLVAQLSMDRLQMLEAICKHWAGPISLALYMSDAEAQQFLRYAQASEVLSARRNVAYHIVYKEGQFYPINLLRNVALANTQTPYVFLTDIDFLPMYGLYDYLRNSIQQLELPHRKAALIVPAFETLHYRLTFPKSKAELLSMLDMGSLYTFRYHVWPKGHAPTDYAKWRTATVPYRVAWQPDFEPYVVVRRDCPKYDQRFVGFGWNKVSHIMELDAQEYELLVLPNAFMIHMPHAPSFDISKFRLSAGYRGCLQTLREEFHQDLSRKYGAAALKYLTAERNL
What is the function of this protein?
Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner.  Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity).  Supports the maturation of DAG1 more effectively than LARGE1 (By similarity).  In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity).
What are the official names of this protein?
Xylosyl- and glucuronyltransferase LARGE2s, Glycosyltransferase-like 1B, LARGE xylosyl- and glucuronyltransferase 2.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: PGK_LACDL
Sequence: MAKLIVSDVDVKDKKVLVRVDFNVPIKDGVIGDDNRIVAALPTIKYIIENGGKAILLSHLGRIKSDEDKKSLSLAPVAKRLGELLEKPVTFVPSNEGKEVEDAINNMKDGDVVVLENTRFQDIDNDFGKRESKNDPKLGEYWASLGDVFVNDAFGTAHRSHASNVGIATAMKAAGKPVAAGFLLEKEIKFLGNAVANPVHPFVTILGGAKVSDKIGVITNLIPKADHIIIGGGMAYTFLKAQGHNIGKSLVEDDKVEFAKELLEKAGDKLVLPIDHVAATEFNNDAASEVVGQDIPDNEMGLDIGPKTIELFKKTLEGAKTVVWNGPMGVFEMPNFAKGTLEVGRALADLPDATTIVGGGDSTAAAKQLGIAPKLTHISTGGGASLEYLEGKELPGIACVSDK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEA6_YEAST
Sequence: MNNGDNKTTLENSKNASLANGNYAIPTKLNRLKKNADPRVAAISGALSGALSAMLVCPFDVAKTRLQAQGLQNMTHQSQHYKGFFGTFATIFKDEGAAGLYKGLQPTVLGYIPTLMIYFSVYDFCRKYSVDIFPHSPFLSNASSAITAGAISTVATNPIWVVKTRLMLQTGIGKYSTHYKGTIDTFRKIIQQEGAKALYAGLVPALLGMLNVAIQFPLYENLKIRFGYSESTDVSTDVTSSNFQKLILASMLSKMVASTVTYPHEILRTRMQLKSDLPNTVQRHLLPLIKITYRQEGFAGFYSGFATNLVRTVPAAVVTLVSFEYSKKYLTTFFQ
What is the function of this protein?
Mitochondrial inner membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:16291748, PubMed:32906142).  Can transport NAD(+) by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP (PubMed:16291748).  Also able to transport NAD(+) by exchange with AMP, GMP or deamido-NAD (+) in vitro (PubMed:16291748).
What are the official names of this protein?
Mitochondrial nicotinamide adenine dinucleotide transporter 2, Mitochondrial NAD(+) transporter 2.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: METXS_CUPPJ
Sequence: MTDVALPPAALTLPNDSVGVVTPQRMHFQEPLKLRNGSSIAGYDLMVETYGTLNADRSNAVLVCHALNASHHVAGVYADDPRDVGWWDNMVGPGKPLDTNRFFVIGVNNLGSCFGSTGPMSTNPATGEPYGAAFPVVTVEDWVNAQARVADVFGITQFAAVMGGSLGGMQAVAWSLMYPQRLRHCIVVASTPKLSAQNIAFNEVARSSILSDPDFHGGNYYAHGVKPKRGLRVARMIGHITYLSDEDMAEKFGRELKTEDIRFSFDVEFQVESYLRYQGDKFAEYFDANTYLLITRALDYFDPALAYGGDLTRAMAQTQASFLVASFTTDWRFAPNRSRELVKALLDNKRPVSYAEIDAPHGHDAFLLDDPRYHNLMRAYYDRIAEEIGA
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAA_PHYPA
Sequence: MTIRSPEPEVKIMVEKDPVKTSFEKWAKPGHFSRTLAKGPNTTTWIWNLHADAHDFDSHTNDLEEISRKVFSAHFGQLAVIFIWLSGMYFHGARFSNYEAWLSDPTHIKPSAQVVWPIVGQKILNGDVGGGFQGIQITSGFFQLWRASGITSELQLYTTAIGGLIFAALMLFAGWFHYHKAAPKLAWFQNVESMLNHHLAGLLGLGSLAWAGHQVHVSLPINRLLDAGVDPKEIPLPHEFILNRDLLAQLYPSFSKGLTPFFTLNWSEYSDFLTFRGGLNPVTGGLWLTDTAHHHLAIAVLFLVAGHMYRTNFGIGHSMKEILEAHKGPFTGEGHKGLYEILTTSWHAQLAINLAMLGSLTIIVAHHMYAMPPYPYLATDYATQLSLFTHHMWIGGFLVVGAAAHAAIFMVRDYDPTTQYNNLLDRVLRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIQNTHALAPSLTAPNATASTSLTWGGGDLVAVGGKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSISDQGVVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLLFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPAIQPRALSIVQGRAVGVAHYLLGGIATTWAFFLARIISVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GUAC_STAS1
Sequence: MKIFDYEDIQLVPNKCIVNSRSECDTTIQFGPRSFKLPVVPANMQTVMNETLAEWFAENDYFYIMHRFDEEGRIPFIKKMQEKGLFASISVGVKEREFGFVESLAAENVIPEYITIDIAHGHSDSVINMIKHIKKHIPEVFVIAGNVGTPEGVRELENAGADATKVGIGPGRVCITKIKTGFGTGGWQLSALNHCSKAARKPIIADGGIRTHGDIAKSIRFGASMVMVGSLFAAHEESPGETVELDGKMYKEYFGSASEFQKGEHKNVEGKKMFVEHKGSLFNTLTEMQQDLQSSISYAGGKDLNSLRKVDYVIVRNSIFNGDRDQNL
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: EAF6_ASHGO
Sequence: MEKQRKEYEELKQKLKQALHEKKVQEQEWDQIQQEIFDKETEYLSGNASSKYGTIVKGFDGFGKHASQDSHHFQDQDRIFSLSSALFVKQQEGVQDEE
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Chromatin modification-related protein EAF6.
What is the protein family that this protein belongs to?
Belongs to the EAF6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPX_ECO45
Sequence: MTDKRKDGSGKLLYCSFCGKSQHEVRKLIAGPSVYICDECVDLCNDIIREEIKEVAPHRERSALPTPHEIRNHLDDYVIGQEQAKKVLAVAVYNHYKRLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAGLDKVISHRVETGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKFGLIPEFIGRLPVVATLNELSEEALIQILKEPKNALTKQYQALFNLEGVDLEFRDEALDAIAKKAMARKTGARGLRSIVEAALLDTMYDLPSMEDVEKVVIDESVIDGQSKPLLIYGKPEAQQASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: RPV1_VITRO
Sequence: MASTSSFRASSSSSTPSIPRTTTYDVFLSFRGEDTRYNFTDHLYSALGRRGIRTFRDDRLRRGEAIAPELLKAIEESRSSVIVFSENYAHSRWCLDELVKIMECQKDLGHAVFPIFYHVDPSHVRKQEGSFGEAFAGYEENWKDKIPRWRTALTEAANLSGWHLLDDRYESNQIKEITNSIFRQLKCKRLDVGANLVGIDSHVKEMILRLHLESSDVRMVGIYGVGGIGKTTIAKVIYNELSCEFEYMSFLENIREGSNPQVLFHLQNQLLGDILEGEGSQNISSVAHRASMIKDILLSRRVFIVLDDVDDLSQLEYLLGHREWLGEGSRVIITTRNKHVLAVQEVDDLYEVEGLNFEEACELFSLYAFKQNLPKSDYRNLTCRVVGYCQGLPLALKVLGSLLCKKTIPQWEGELKKLDSEPKADIHKVLKRSYDGLDRIDKNIFLDLACFFKGEGRDFVLRILDGCDFPAETGISNLNDLCLITLPYNQICMHDLIQQMGWEIVRENFPVEPNKWSRLWDPCDFERALTADEGIKSVETMSLDLSKLKRVCSNSNVFAKMTKLRLLKVYSSSDIDSAHGDSDEDIEEVYDVVMKDASKMQLGQSFKFPSYELRYLRWDGYPLDSLPLNFDGGKLVELHLKCSNIKQLWQGHKDLERLKVIDLSYSRKLSQMSEFSSMPNLERLCLSGCVSLIDIHPSVGNMKKLTTLSLRSCNKLKNLPDSIGDLESLESLYLSNCSKFEKFPEKGGNMKSLTELDLKNTAIKDLPDSIGDLESLESLYLSNCSKFEKFPEKGGNMKSLTELDLKNTAIKDLPDSIGDLESLEILNLSDCAKFEKFPEKGGNMKSLKELDLQNTAIKDLPDSIGDLKSLKYLSLSDCSKFEKFPEKGGNMKRLLQLILSNTAIKDLPDSIGDLESLKYLYLSDCSKFEKFPEKGGNMKSLTELDLKNTAIKDLPDSIGDLESLEILNLSDCAKFEKFPEKGGNMKSLKELDLQNTAIKDLPDSIGDLESLKYLYLSDCSKFEKFPEKGGNMKSLLQLILSNTAIKDLPDSIGDLESLEYLHLSVCSKFEKFPEKGGNMKSLRELGLRNTAIKDLPDSIGDLESLEMLSLSNCPKFEVLPLSLKAIDAHLCTSKEDLSRLLWLCHRNWLKSTTEEFDRWQLSAFIPESSGIPEWITYQNLGSEVTEKLPINWCEDPDFPGFVLSCVYRPSCDYSSAYIFCHDFKCELNLHGNGFRFRDVCYHECWCDCHVNFKDSRDLVCVYWYPKTAIPEEDHHKYTHINASFKSDEVKIKKCGINVIFLGDQRNHMPMLEHPQNSGDNGSALQDANGNVHGANQDDEHYHIPLLDLLRNLSLGDNGSVVLEDTLGNRKRRRNDSLPDVVEEPLYKRLGGPHTEISL
What is the function of this protein?
Disease resistance (R) protein that confers resistance to multiple powdery and downy mildew by promoting cell death (PubMed:24033846, PubMed:28008335).  Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792).
What are the official names of this protein?
Disease resistance protein RPV1, NAD(+) hydrolase RPV1, Resistance to Plasmopara viticola protein, MrRVP1.
What is the protein family that this protein belongs to?
Belongs to the disease resistance TIR-NB-LRR family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: APOH_HUMAN
Sequence: MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC
What is the function of this protein?
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate.  May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
What are the official names of this protein?
Beta-2-glycoprotein 1, APC inhibitor, Activated protein C-binding protein, Anticardiolipin cofactor, Apolipoprotein H, Apo-H, Beta-2-glycoprotein I, B2GPI, Beta(2)GPI.
Protein: OBG_DINSH
Sequence: MKFLDLAKVYIRSGGGGTGAISFRREKYIEYGGPDGGDGGRGGDVWVEAVDGLNTLIDFRYQQHFFAKSGQHGMGKQRTGKDGAGVTLRVPVGTEILEEDEETVIADMTEIGQRVLLAKGGNGGFGNLHFKSATNQAPRRANPGQPGVERTIWLRLKLIADAGLLGLPNAGKSTFLAATSNARPKIADYPFTTLHPNLGVVGVDGTEFVMADIPGLIEGAHEGRGIGDRFLGHVERCAVLLHLVDGTAEDVVADYRTILTELQAYGGALATKPRVTALNKIDALDEQERAEKAAALQAASGFPVLQLSGVSGEGVQDVLRAVRRRIDGARQAEEATDREDTSWQP
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIS_THEON
Sequence: MAELFREVTKEERVLYYKAEWNAKKLPRFLVEKLENREFGFDHTGEGPSDRKNVFMDVRDLEDYIKATAPYAIYSSVALYEDPKGMSGWLGAELVFDIDAKDLPLRRCGHIHEHGKVCPICLGDAKELARDTLVILKEDFGFEDVHVVYSGRGYHIRVLDDWAIQLDSKSREKILAYISAAEEVTFEDIQSRKIMLSSGYFRVFRLRFGYFIARANENHLLNIGLRKGQVKKILESRDEIYEGFVRKGLLTAFPQGIGYKTLARLFALSSTFSKAYFDGRVTVDVKRILRVPSSLHSKVGLVATYIGSDERKLEKFNPFRDAVPKFREEEVKEAYEEWLELHGDEL
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: RSMF_SALPB
Sequence: MAQHAVYFPDAFLTQMREAMPSTLSFDEFISACQRPLRRSIRINTLKISVADFLALIAPYGWSLTPIPWCHEGFWIERDDEEALPLGSTAEHLSGLFYIQEASSMLPVAALFADDNHPQRVMDMAAAPGSKTTQIAARMGNRGAILANEFSASRVKVLHANISRCGIANTALTHFDGRVFGAALPEMFDAILLDAPCSGEGVVRKDPDALKNWSPESNLDIAATQRELLDSAFHALRPGGTLVYSTCTLNRQENEAVCLWLKETYADAVEFLPLGDLFPDADRALTPEGFLHVFPQIYDCEGFFVARLRKMSSLPAMPAPGYKVGAFPFTPLKGREALHVTQAANAVGLLWDENLHLWQREKEVWLFPAEIESLIGKVRFSRLGIKLAESHNKGYRWQHEATIALACPTHAHAFELSAQEAEEWYRGRDIYPQTPPAADDVLVTFQRQPLGLAKRIGSRIKNSYPRELVRDGKLFTGNS
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPD_METKA
Sequence: MPLREAAERVVEAETVVVLTGAGASADSGIPTFRGKDGLWNKYDPRELATPEAFARDPEKVWEWYLWRRRKIAEAEPNPAHTVLARMERDGLLEAVITQNVDGLHQRAGSRRVIELHGNIWRDECVSCEYQRVNDPERGEGLEYDELPPRCPECGDPLRPGVVWFGEPLPSDALVEAENLARSCDVMLVIGTSGEVRPAADLPLVAKSCGATLIEINPSETALSPHMDVIIRERAASAMEALWNEIERLL
What is the function of this protein?
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins.  Modulates the activities of several proteins which are inactive in their acylated form.  Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
What are the official names of this protein?
NAD-dependent protein deacylase, Regulatory protein SIR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT2L1_BOVIN
Sequence: MCELYSKQETLALRRKHIGPSCKVFFAADPIKIVRAQRQYMFDEKGDQYLDCINNVAHVGHCHPEVVKAAQKQMELLNTNSRFLHDNIVEYAKRLSATLPDRLSVCYFTNSGSEANDLALRLARQFRGHQDVITLDHAYHGHLSSLIEISPYKFQKGKDVKKEFVHVAPAPDTYRGKYREDHVDPASAYADEVKKIIDEAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVRGAGGVFIADEVQVGFGRVGKHFWSFQMFGEDFVPDIVTMGKPMGNGHPMACVVTTKEIAEAFSASGMEYFNTYGGNPVSSAVGLAVLDVIKNEDLQGNATRVGNYLTELLNKQKTKHTLIGDIRGVGLFIGIDLVKDHQQRTPATAEAQHIIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVEQLDGILTGLEEATGAETESGISKNTPCRTKMPKEAQSELLRDSSLESRENPSQKRNGLCTDSLLSKRLRT
What is the function of this protein?
Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.
What are the official names of this protein?
Ethanolamine-phosphate phospho-lyase, Alanine--glyoxylate aminotransferase 2-like 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RB_RAT
Sequence: MPPKAPRRTAAAEPPPPPPPPPEDDPAQDSDPEELPLIRLEFEKIEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFIAAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDTSTKVDNAVSRLLKKYNVLCALYSKLERTCGLIYLTQPSSGLSTEINSMLVLKVSWITFLLAKGEVVQMEDDLVISFQLMLCVLDYFIKLSPPALLREPYKTAATPINGSPRTPRRGQNRSARIAKQLESDTRTIEVLCKEHECNVDEVKNVYFKNFIPFISSLGIVSSNGLPELESLSKRYEEVYLKSKDLDARLFLDHDKTLQTDTIDSFETERTPRKSNPDEEANMVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISYFSNCTVNPKENILKRVKDVGHIFKEKFASAVGQGCIDIGAQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSMLQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKVEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGPDHLESACSLSLPLQSNHTAADMYLSPIRSPKKRTSTTRVNSAANTETQAASAFHTQKPLKSTSLSLFYKKVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLENEYELMKDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFSSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGSDEADGSKHLPAESKFQQKLAEMTSTRTRMQKQKLNDSMEISNKEEK
What is the function of this protein?
Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle.  The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes.  Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription.  Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase.  RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C.  Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.  Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression.  Controls histone H4 'Lys-20' trimethylation.  Inhibits the intrinsic kinase activity of TAF1.  Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter (PubMed:19081374).  In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex.  Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity).
What are the official names of this protein?
Retinoblastoma-associated protein, pRb, Rb, pp105.
What is the protein family that this protein belongs to?
Belongs to the retinoblastoma protein (RB) family.
What are the subcellular locations of this protein?
Nucleus.