PharMolix/UniProtQA huggingface dataset:
Protein: RPB2_HUMAN
Sequence: MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II subunit B, RNA polymerase II subunit 2, RNA polymerase II subunit B2.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PATR_MYCS2
Sequence: MSIRLRAEMADLPAYAPGKTVPGAIKIASNETVHGPLPSVREAILKATDLINRYPDNGYLDLRERLAKHVNFAPENISVGCGSVSLCQQLIQITSSVGDEVLFAWRSFEIYPLQVRTAGATPVAVALRDHTHDLDAMLAAITDRTRLIFVCNPNNPTSTVVDPGELARFVAAVPPHILVVLDEAYVEYIRDGLLPDSLGLVREHRNVVVLRTFSKAYGLAGLRVGYAVADPEIVTALGKVYVPFSATSVSQAAAIACLDAADELLARTDAVVAERTRVSDALRAAGYTLPPSQANFVWLPLAERTLDFVARAADNRIIVRPYGEDGVRVTIGAPHENDAFLDFAQRWIAPGGAGPRTGDSA
What is the function of this protein?
May catalyze the transamination reaction in phenylalanine biosynthesis.
What are the official names of this protein?
Putative phenylalanine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: MNTP_DEHM1
Sequence: MSLLSVVFVALALSADCFAVSIGIACTHTDVKPRIMWRVAGTFGLFQAGMAVIGYYAGLSIADVISSFDHWVAFGLLTVIGGRMVYESVQGEDDQKLVRLDLTRGLGLLGVAIATSIDALAVGLTFSLSETNIGLAALLVGAVSLAVSYLGFKLGNRISHLASRWVGIAGGLILCLIGLKILAEHTLGWDILL
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PUR5_METTH
Sequence: MVTYSESGVDIDLEELTVSSLTSRLSDTLKYCDVITGAGHFAALVRMGDVAIAMSTDGVGSKILVAEMMNRYDTVGIDCIAMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGKGLAMGAEMARVAIIGGETASLPGIIRNLDLAATGIGFVDVDRIITGEDVSPGDTVIGLESSGIHSNGLSLARRVFFDELELSPEDEMPGSSSSVGDELLRPTRIYVEPIMELIESDVDVHGLAHITGGGFGNLKRLRKDVGYRLDSLPEPQQIFRVIHEAGVDIREMYRVFNMGVGFCAVVAPDDVDEALSILGDRAHPIGEVTDRGSEVELEACTGETIKL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMGB3_HUMAN
Sequence: MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLNDSEKQPYITKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKVEEEDEEEEEEEEEEEEEEDE
What is the function of this protein?
Multifunctional protein with various roles in different cellular compartments.  May act in a redox sensitive manner.  Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA.  Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity).  Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity).  Negatively regulates B-cell and myeloid cell differentiation.  In hematopoietic stem cells may regulate the balance between self-renewal and differentiation.  Involved in negative regulation of canonical Wnt signaling (By similarity).
What are the official names of this protein?
High mobility group protein B3, High mobility group protein 2a, HMG-2a, High mobility group protein 4, HMG-4.
What is the protein family that this protein belongs to?
Belongs to the HMGB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm.
Protein: RISB_DESVV
Sequence: MLHIKTIEGQLDAKGLKFAIVATRFNDFIVDRLIGGACDYLQRHGCDRENLTIVRIPGAFEMPLVAKKLAHSGKYDGIIALGAVIRGATPHFDFVSNEASKGLAQACLESGVPLGFGLLTTDNIEQAIERAGSKAGNKGAEAAAAVLETVRVMEQL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: PER1_ZINVI
Sequence: MSYHKSSGTILMVPLFMLLISVNYFMSCNAQLSTTFYDTTCPTALSTIRTSIRSSVSSNRRNAALVIRLLFHDCFVQGCDASLLLSGAGSERASPANDGVLGYEVIDAAKAAVERVCPGVVSCADILAVAARDASVAVGGPSWTVRLGRRDSTTSNAAQAATDLPRGNMVLSQLISNFANKGLNTREMVALSGSHTLGQARCIRFRGRIYNSTLRIEPNFNRSLSQACPPTGNDATLRPLDLVTPNSFDNNYYRNLVTSRGLLISDQVLFNADSTDSIVTEYVNNPATFAADFAAAMVKMSEIGVVTGTSGIVRTLCGNPS
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.  Involved in the synthesis of highly polymerized lignins.
What are the official names of this protein?
Basic peroxidase, ZePrx33.44, ZePrx34.70.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RDGC_PSEE4
Sequence: MWFKNLLTYRLTQDVPFEPEALEAALASKPARPCASQELTTYGFVAPFGKGADAPLVHVSGEFLLIAARKEERILPSSVVNDAVKEKVEEIETEQMRKVYKKERDQIKDEIIQAFLPRAFIRRSMIFAAIAPRLGLILVNSASAKRAEDLLSTLREVMGSLPVRPVTVKIAPAATMTDWVKSQHAAEGFYVLDECELRDTGEDGGIVRCKRQDLTGEEIQLHLSTGKVVTQLALAWQDKLSFVLDDKTVIKRLKFEELLQEQAEQDGGDEAQQQFDASFTLMMMTFTEFLPALFEALGGEEIPQGV
What is the function of this protein?
May be involved in recombination.
What are the official names of this protein?
Recombination-associated protein RdgC.
What is the protein family that this protein belongs to?
Belongs to the RdgC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ICLN_XENLA
Sequence: MNLLSSFPPPADGVRRLQPGTEAVVGGRGLGPGTLYIAESRLSWLNGSGLGFSLEYPSISLHAISRDTAAYPEEHLYVMVNSKLADKEDKEAHMADQEEEESEDDDDDEEPITEIRFVPGEKSDLGEMFSAMCDCQALHPDPEDADSDDDYEGDEYDVEAHEQGQVDVPTFYTYEEGLSHLTTEGQATLERLENMLSNSIGNQHTMAGVRTEGPALEPEDGMDVENTQTVAGQFEDADVDH
What is the function of this protein?
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity).  Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity).  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity).  Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
What are the official names of this protein?
Methylosome subunit pICln, Chloride conductance regulatory protein ICln, I(Cln).
What is the protein family that this protein belongs to?
Belongs to the pICln (TC 1.A.47) family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton.
Protein: ITF2_MOUSE
Sequence: MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGTGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNARRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPAASTFPSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIMGPSHNGAMGSLGSGYGTSLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM
What is the function of this protein?
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif.  Involved in the initiation of neuronal differentiation.  Activates transcription by binding to the E box (5'-CANNTG-3').  Isoform 2 inhibits MYOD1 activation of the cardiac alpha-actin promoter.  Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription.  May have a regulatory function in developmental processes as well as during neuronal plasticity.
What are the official names of this protein?
Transcription factor 4, TCF-4, Class A helix-loop-helix transcription factor ME2, Immunoglobulin transcription factor 2, ITF-2, MITF-2, SL3-3 enhancer factor 2, SEF-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: NUON_CITK8
Sequence: MTITPQHLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNQEEFYLLVLIAALGGILLANANHLAALFLGIELISLPLFGLIGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGNLSFVALGKSLGDGMLHEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAVRIVLGVIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQSGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPFRGPDADSLFSYRGLFWHRPILAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQASLWWLVAAVVVGSAIGLYYYLRVAVSLYLSAPQQLNRDAPSNWQYSAGGIVVLISALLVLVLGIYPQPLISIVQLATPLM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD_ESCF3
Sequence: MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNGFLLDGFPRTIPQADAMKEAGINVDYVLEFDVPDELIVDRIVGRRVHAPSGRVYHVKFNPPKVEGKDDVTGEELTTRKDDQEETVRKRLVEYHQMTAPLIGYYSKEAEAGNTKYAKVDGTKPVAEVRADLEKILG
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB_CARSF
Sequence: MVHLTAEEKAAVTALWGKVDVEDVGGEALGRLLVVYPWTQRFFDSFGDLSTPAAVMSNAKVKAHGKKVLNAFSDGMAHLDNLKGTFAKLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVATALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PB2_I79A4
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMSDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKVYKTYFDKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSMYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAIVRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFHKDAKVLFQNWGIEHIDSVMGMVGVLPDMTPSTEMSMRGIRVSKMGVDEYSSTEKVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTERLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKTTKRLTILGKDAGTLIEDPDESTSGVESAVLRGFLILGKGDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: RS20_ACIF2
Sequence: MANTAQARKRVLQNEKRRLHNASLRSRLRTYVKGVLKAVHVGDQEQARSALRAAESVIDKTVGKGVAHRNMAARTKSRLSARVKAMGNAAQ
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ACBD5_BOVIN
Sequence: MFQFHAGSWESWCCCCCLIPGDRPWDRGRRWRLEMADTRSVHETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSKPGFWDPVGRYKWDAWSSLGDMTKEEAMIAYVEEMKKILETMPMTEKVEELLHVIGPFYEIVEDKKSGRSSDLTSVRLEKISKCLEDLGNVLASTPNAKTVNGKAESSDSGAESEEEAAQEDPKRPEPRDSDKKMMKKSADHKNLEIIVTNGYDKDSFVQGVQNSIHTSPSLNGRCTEEVKSVDENLEQTGKTVVFVHQDVNSDHVEDISGIQHLTSDSDSEVYCDSMEQFGQEESLDGFISNNGPFSYYLGGNPSQPLESSGFPEAVQGLPGNGSPEDMQGAVVEGKGEVKRGGEDGGSNSGAPHREKRAGESEEFSNIRRGRGHRMQHLSEGSKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLHKLEMLAASQAKSSALQTSNQPTSPRPSWWPFEMSPGALTFAIIWPFIAQWLVHLYYQRRRRKLN
What is the function of this protein?
Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy.  Binds medium- and long-chain acyl-CoA esters (By similarity).
What are the official names of this protein?
Acyl-CoA-binding domain-containing protein 5, Endozepine-related protein, Membrane-associated diazepam-binding inhibitor, MA-DBI.
What is the protein family that this protein belongs to?
Belongs to the ATG37 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: RIC1_YEAST
Sequence: MFIKQSEKNTPKCLYKKKGKVRVLLTGSCKKLNTWKMHLWPVSPPQLLRIPPRNAELGEGTKIDDCNILQSMTLPQANVLIMLTPTRVLIYNFKPMALVASHERTMASLKEFGDNRSMKRSAPYNDIIEGLISKKDSQYLLWHQGKLIFYVMTDKNFLLTYQILKNCTNEIIFKEYGIPVIEPLLMSEEEANSAEYDYNNDDDTLTVFDKNSSSRIIQNGFGITKEKGFLHFLSNQENIDELPVKKLELRLKVVLKFDYEIIDMIGIKTFSKVGDGRYEEVLIVLFPHGLQILTISDFKVSKSSLVEVKKGSKTIVCNKQLMVLSHDSVEKQTIVSIIDIEKQAVEAIPLTDTPDELLTCLEVNGYLVVVYKEKIICFDTRIKKVSHSWKPPFVIKLCDKINDKILLLVSEDSVNIHFYTEFGNLLFATYFDEDDYNGDNNNDNSKDKNEKKAAEYKISDFVCLDKSLITVSHSGKYQVWKLWEEIKQTQFDFRNPKCYVLTNTNNDVIIYSPVTSSSINNDNLQVIKLPTKTFNNHIAFVKINSSLRLFATYVSNKNILLIHNLETNMWSSFADQNVLDLHWLGDNYLVCHMKNDDGSTNLKCLQIPLQEANPDVELSDYVMWEYNVPENTIVFSLHVNTLSRYKLLKMKSKNHNASEKQPDALLKTAEIILVTDTQTIVFDVISTVHPCGLNIIKKFYQYLKINIPIDVLPNKIEWIINMKEGLLFFADRKFIKLGKVDGGGWQTLTLLDNIEKIIDVIRDEIFVVQGHNYVVYSLEDLWDDKKPLVSIPIEEDLYPISTTPETATTHTLHCIFNARFSKLVVKHQIYLDQLILAKLEDNTDLEDISHNYRFLKPYKFALEKILSTKILRSDSLDDILKLIKMYDNTDPEHNISPPTHSGMLEIISNCLRKIETKYWNHLFTNLKMTPRDLLALCIEENEAKMLGVLLLVFLNYDEKDLGDDLHFKKSDLGTEESKALNDNSTKKSEKSVTNLLKDEELMLKVLELLVTSAANATDPIKATDSWDMCFQLIRLLKELDRENNTQLVQKALERFK
What is the function of this protein?
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP.  It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi.  The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment.  May also be indirectly involved in the transcription of both ribosomal protein genes and ribosomal RNA.
What are the official names of this protein?
Guanine nucleotide exchange factor subunit RIC1, Protein RIC1, Ribosome control protein 1, Ric1p.
What is the protein family that this protein belongs to?
Belongs to the RIC1 family. Highly divergent.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: ZSCA2_MOUSE
Sequence: MAAEVPAVSTPLSPLVQVPQEEDEQAEVTTMILEDDAWVQEAVLQEDGPESEPFPQSAGKGSPQEEDAAEGPQGALVRFRELCRRWLRPEVHTKEQMLTVLPREIQAWLQEHRPESSEEAVALVEDLTQTFRHSDFEIQSENGENSNEDMFEGVESHGMFLNISGGEGGQQSDGDSDFERDCGSGGAQGHAPGEDPRVVPSEGREVGQLIGLQGTYLGEKPYECPQCGKTFSRKSHLITHERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITHQRIHTGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTHQGIHTGEKPYACKECGESFSYNSNLIRHQRIHTGEKPYKCTECGQKFSQSSALITHRRTHTGEKPYQCGECGKNFSRSSNLATHRRTHLVEKPYKCGLCGKSFSQSSSLIAHQGTHTGEKPYECLTCGESFSWSSNLIKHQRTHTGEKPYRCGDCGKGFSQRSQLVVHQRTHTGEKPYKCLMCGKSFSRGSILVMHQRAHLGDKPYRCPECGKGFSWNSVLIIHQRIHTGEKPYRCPECGKGFSNSSNFITHQRTHLKEKLY
What is the function of this protein?
May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
What are the official names of this protein?
Zinc finger and SCAN domain-containing protein 2, Zinc finger protein 29, Zfp-29.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
Protein: PSBA_JASNU
Sequence: MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAIEAPSTNG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RLME_CAUSK
Sequence: MVKPPAGGNDGGRAKPARLKTAFGRTPSQQAWLERQINDPFSAKARALGYRSRAAFKISEIDDKYRFFKKGAKVIDLGCAPGGWLQMATERGVTDIVGVDLLPVDPVAPAHILEMDFTDPACPPKMLELLGGAPDLVMSDMAPNTVGHRETDHLRIVGLIEIGADFAIEVLKPGGAFVAKAFQGGETAAVIAQLKKHFTKVVHFKPKASRSDSSEVFLVATGFKGR
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_NITHX
Sequence: MSRPVPNPGILDIAPYTPGKSPVPEAGRKVFKLSANETPFGPSPKAMDAYRNAVAHLQDYPEGTSRVLREAIGRAYGLDPDRIICGAGSDEILNLLAHVYLSHGDEAVSTTHSFLVYPIATTANGAENVVAPEVDYTADVDAILQRVTPKTKMVWLANPNNPTGTYLPFDEIKRLHGGLPPHVLLVLDAAYSDYVSRNDYELGIELAATTGNTVLTHTFSKIHGLAALRIGWMFGPAHVVDAVNRIRGPFNVSTPAMLAAAAAIGDTAHVQMSKVHTEKWRNWLTDEVTKLGLKVTPSVTNFILIHFPTTKGKTASEADAFLTKRGLVLRALDNYGLPNALRMTIGTEEANRLVADGLRDFMAQK
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: RECR_AQUAE
Sequence: MEDFWEDWDLAFEDVFPKSLKEALEGIKEIPTYGERGASRFMYNLLKLEKEKRKEIIEKVLEAVEVLRPCRECFLITDREVCPICSDEKRSKKFICVVEESQDAYAIEKLERYKGVYHVLQGHIAPLEGISAEDLTIDALMERIKKYQPKEVILATNPNVEGEATANYIAGLIRRKFPAVKITRTAYGFQFGSLIEFVDEYSLEKSMENRK
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.