PharMolix/UniProtQA huggingface dataset:
Protein: RL4_MYCGE
Sequence: MAKLKVIQFDGSFKGEIQPANHLLLKKAVIQPVFDAILLEQAACRQGTHSTLTKGEVSGGGKKPYKQKHTGKARQGSIRNPHYVGGGVVFGPKPNRNYKLKLNKKAYQLALTSAFAQKLNNNQVIVAEAKLFEQTNAKTKKMLTFLKNAKLTEQKLLFVIDTISKPLLLSTNNLKQIVVKQFNKVSVRDLLLAKTIIIEKAAFTKLEERLK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: EFG_OCEIH
Sequence: MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAAWRDHRINIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVWRQATTYGVPRIVFINKMDKTGADFLYSTGTLKERLGANAHPIQMPIGAEDEFHGIIDLITMDAYFYLDDLGQRSETREIPAEYKDEAEELRASLIEAVAETDEELMMKYLEGEEISNDELKTAIRQATLNVDFYPVLCGSAFKNKGVQLMLDAVLDYLPAPTDVPPIEGIIPGTEEKVTRPSSDDEPFSALAFKVMTDPYVGKLTFFRVYSGTLDSGSYVKNSVKDKRERVGRILQMHANSREEISRAYSGEIAAAVGLKDTSTGDTLCDEKNLVILESMDFPEPVISVAIEPETKADQDKMAIALSKLAEEDPTFRTETNPETGQTIISGMGELHLDIIVDRLKREFKVGAQVGAPQVSYRETFRGSAEVEGKFVRQSGGRGQFGHVWVKFEPNEEGAGFEFENKIVGGVVPREYIPAVQQGIQESMENGVLAGYPLIDIKATLYDGSYHDVDSNEMAFKVAASMALKAAKNKCKPVLLEPMMRVEVVVPEEYMGDIMGDVTSRRGRVEGMEARGTAQVVKAFVPLSEMFGYATALRSNTQGRGVYTMHFDHYEETPKSITEEIIKKNAGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATA_CHICK
Sequence: MDFSKLPKIRDEDREAFVGYVQGVSGPVVTACNMAGAAMYELVRVGHSELVGEIIRLEGDLATVQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISTLTKSIYIPRGVNVSALSRDVKWDFTPSKNLRVGSHITGGDIYGVVNENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEGVKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPEREGSVTIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYTRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMIAFYDMRRRAVENTAQSDNKITWSIIRENMSEILYRLTSMKFKDPVKDGETKIKADYAQLFEDMQNAFRSLED
What is the function of this protein?
Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).  May play a role in neurite development and synaptic connectivity (By similarity).
What are the official names of this protein?
V-type proton ATPase catalytic subunit A, V-ATPase subunit A, V-ATPase 69 kDa subunit, Vacuolar proton pump subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OXR1_PODAS
Sequence: MSFYTSSSSQKTHNLNTRQSPDPDSSPASSPGAITPTTSHTETAGSSYFSNLLWGGLFRRFTSEPSPSLSTENSPPTLRHAHTYQPDGEDDGRNLGKSVDGIYTPPHFHHRVPSPMGLPQLEPLQLLGFSARTRTESRLLTPAIAEEVRNLVPTRLSIVDEWNLVYSLDQDGSSLATLYDKCDRYRGKRVGFVLAVRDTEGGIFGAYLSDVPHIAPNYFGTGECFLWRASVQAPLPPPPSLIDSEDTPDVGRSTTIRAEQNVASGQVNAHSIRFKAFPYSGVNEYYMLCGQQFLSVGAGDGRFGLWLDSGLEKGVSSTCQTFGNEPLSDEGEKFGVLGVELWVIGA
What is the function of this protein?
May be involved in protection from oxidative damage.
What are the official names of this protein?
Oxidation resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the OXR1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CCME_SHEB5
Sequence: MNPRRKKRLTLAVALIGGVAAITSLLLYALNSNLNLFYTPSEIVHGKTDTGVKPEIGQRIRVGGMVTVGSMVRDPKSLHVQFAVHDSLGGEVLVTYDDLLPDLFREGQGIVAQGVLSADGKLEATEVLAKHDENYMPPEVAEAMGQKHEKLDYSQQKAPDTK
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: NUOD_VESOH
Sequence: MSEIRNYTLNFGPQHPAAHGVLRLILEIDGEVIERADPHIGLLHRGTEKLVESKPYNQSIGYMDRLDYVSMMCNEHAYVMAIEAMLNLKVPKRAQYIRVMFDEITRILNHLMWLGTHGLDVGAMSIFLYAFREREKLIDCYEAVSGSRMHATYYRPGGVYRDLPDKMPQYLASDFRTSKELETMNENRQGSLLDFIADFVKEFPKSIKQYDDLLTDNRIWKQRLVNIGVVSANRAKQLGFTGPMLRGSGVEWDLRKNQPYAVYDQLKFDIPVGMTGDSYDRYLVRMEEMRQSNYIIKQCVKWLRENPGAVMSDDHKVSQPKRTNMKNDMESLIHHFKLFTEGYCLPEGEVYRAVEHPKGEFGVYLISDGANKPYRVKIRAPGFSHLAAMNEMTRGHMLSDVVTIIGTQDVVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS12_NITHX
Sequence: MPTINQLIASPRVIQKSRKKVPALQQSPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHILRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RPOB_COXBR
Sequence: MAQANSRSRNSATISYPEKRRARVNLGKREVEILKTPYLLETQIESYRKFLQKDIAAEKREDNGLHAAFKSVFPITSYSGYAVLEYVGYSLGGESTLFDVEECKLRGLTYAAPLKVNMRLVIYDKEAPAGKKAIKDIKEQEVYMGEIPLMTETGSLVINGTERVVVSQLHRSPGVFFEHDKGKTHSSGKLLYSARVIPYRGSWLDFEFDPKDCLFVRIDRRRKLPATVILRALGYDTEQILDMFYKTNHFHLNQETVTLDLIPQRLRGELAVVEIKDKKGKVIVEANRRISARHIRLIEKAEINKLELPDDYLYGKVIGKTIIDKETGEIIAHANEEITAELLKNLRATKTASLDTLYINEIECGPYVSDTLRLDTTTNQLEALVEIYRIMRPGEPPTKEAAESLFENLFFSPERYSLSAVGRMKFNRRVGRKELTGLDVLSKEDIVDVLRVLVDIRDGKGDVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKDRLSLADVENLMPQDLVNAKPVSAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHVTHYGRVCPIETPEGPNIGLINSLAVFARANEYGFLETPYRKVVDRVVTDETEYLSAIEEGDYYIAQANTNVDGKGRLVDDLISCRYKGEFTLTTPDKINYMDVSPRQIVSVAAALIPFLEHDDANRALMGSNMQRQAVPTIRPETPLVGTGMERTVAVDSGVTVIAKRSGVIDSVDASRIVVRVDRKETEDDDDIGVDIYNLTKFTRSNQNTCINQHPIVEVGDKVQKGDVLADGPSTDIGELALGQNLLVAFMPWNGYNFEDSILISERLVEEDRFTTIHIQEFTCVARDTKLGPEEITSDIPNVGESALAKLDESGIVHIGAEVNAGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVTPGITGTVIDVRIFTREGIKKDERTLEIEKAELSKVEKDLNDELRVREDALFENLEKLLTGRVAAGGPNKLAKGTKITKSYLADLPRQKWFEIRLQDDAATKRLEASHEHFKELRETRDAKLKDSRQKLTQGGDLAPGVIKIVKVYLAVKRRIQPGDKMAGRHGNKGVISTIVPIEDMPYLEDGTPVDIVLNPLGVPSRMNIGQVLETHLGWAAKGLGKKIGEMIEKGADAKELRNSLKPIYDLSKTQRFDLEALEDPEIVTLAKNLRKGVPISSPVFDGATEEEIKQLLKMADLPTSGQAALYDGRTGKKFDRSVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTRMYKNIVDGDHRMDAGMPESFNVLVKEIRSLAIDIGLEND
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: LOLA_NEIG1
Sequence: MMKPHNLFQFLAVCSLTVAVASAQAGAVDALKQFNNDADGISGSFTQTVQSKKKTQTAHGTFKILRPGLFKWEYTLPYRQTIVGDGQTVWLYDVDLAQVTKSSQDQAIGGSPAAILSNKTALESSYTLKEDGSSNGIDYVRATPKRNNAGYQYIRIGFKGGNLAAMQLKDSFGNQTSISFGGLNTNPQLSRGAFKFTPPKGVDVLSN
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PSTB_RHOPS
Sequence: MSEISIATSVPSGPGPLIGNQPDGPAKVIVRDLNFYYGQNHALKHINLSLAANRVTAFIGPSGCGKSTLLRVFNRMYDLYPGQRAEGQVMLDGNNILDPKLDLNLLRARVGMVFQKPTPFPMTIYENIAFGIRLYEKISKSEMDGRVEKALRSAALWNEVKDKLNASGLSLSGGQQQRLCIARTIAVRPEVILFDEPCSALDPISTAKIEELIDELKEDYTIAIVTHNMQQAARVSESTAFMYLGELIEFGPTNKIFTSPNDRRTQDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MURB_SYNSC
Sequence: MTQCDARLPQGGVKLADYTTWRVGGAAEWLAEPASLDETQAWIEWAAHQGMPCRVIGAGSNLLIHDDGLPGLSLCLRKLQGLQLDATTGTVEVLAGEPIPSLARRAARAGLHGLEWSIGIPGTAGGAAVMNAGAQGGCTAEWLESVRVVPLEGGNCFELQRHQLDFAYRHSRLQEDNLVVLSARFRLQPGHDPDELKRVTTANLSHRTTTQPYQQPSCGSVFRNPEPLKAGRLIEEQGLKGTRIGGAEISTVHANFIVNTGDAQAKDIAQLIHLVQDRIEAKHGIRLHTEVKRLGFASAA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1357_YERPS
Sequence: MNINVANLLNGNYILLLFVVLALGLCLGKLRLGSIQLGNAIGVLVVSLLLGQQHFAINTEALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSAMILALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHTMANGSSLQQAQDNLSLGYALTYLIGLVSLILGARYLPKLQHQDLPTSAQQIARERGLDTDSQRKVYLPVIRAYRVGPELVAWADGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQVGDEISLVGYPDAHSRLDPSFRNGKEVFDRDLLDMRIVTEEIVVKNSNAVGKRLSHLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKSVAEKIGFISIHSQVTDLLAFCSFFILGLMIGLITFQFSNFSFGIGNAAGLLLAGIMLGFLRANHPTFGYIPQGALNMVKEFGLMVFMAGVGLSAGGGINSSLGAVGGQMLISGLIVSLVPVVICFVFGAYVLRMNRALLFGAIMGARTCAPAMDIISDTARSNIPALGYAGTYAIANVLLTLAGSLIVILWPGILG
What are the official names of this protein?
Putative transport protein YPTB1357.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YM86_YEAST
Sequence: MFGKVFVSYIRTRIGFKPLSTIYTPVSSSSLSFDKEACFPFKKWHELNMSQKQEFIQRFVKNYRHQYPSSKTNVSLKGLSIGMDEHNDSPSVFGIFYNDIWKSFKNEQLGTNNDNMKSGSRFSHPSFKQLLIQK
What are the official names of this protein?
Uncharacterized protein YMR252C.
Protein: MNMG_PARUW
Sequence: MMLWKFPVRYDVIVIGGGHAGCEAALASARMGLRTLLLTMNLDTIAKMSCNPAVGGIAKGHIVREIDALGGEMGKVIDVTGIQYRMLNATKGPAVWAPRAQADKLAYQSEMKHRMERVSNLDIKQGTIEDLLIENDHICGVITKEGISYDCQAIVLSSGTFLRGLLHIGETNYSGGRAGDQPSVGMSASLEKYGLKLGRLKTGTPPRINKRSIDFSCTEEQPGDPGVKFSYDNEGIPRLPQVSCYITYTTEETKQIILSNIHRSPMYSGKIKGVGPRYCPSIEDKVVRFSDKERHQIFLEPEGLQTQEVYVNGVSSSLPFDVQLAFIKSIPALRHAEIMRPAYAIEYDYVISGQIDFSLECKKIGGLFLAGQINGTSGYEEAAGQGLMAGINAANKVMGKAPLILKRSEAYIGVMIDDLVTKGLDEPYRMFTSRAEHRLLLRQDNADLRLRRYGYEVGLVDQTRYDRVKEKQRIMEEESERLAKTFKQVSNKGYTLTQLLCRPENTYASLLKEYPDVMQNFGEEINFQIELNLKYAGYIDRQTSEVAKLAHVEKIQIPIGFDFSTVNGLRNEAKQKLNQIAPRHLGQALRISGVSPADISILMIALTRYQEPIEKERLTSDCSEA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_STACT
Sequence: MDTAHKIINGYALTKQEAYDLYTDETIDTFTLLDEAYAVRKHYYGKKVKLNMILNAKSGICPEDCGYCGQSRDMKRKDRYALIPENDIIAGANAAADNQIGTYCIVMSGRGPSDKEVDHITESVRQIKENHPQLKVCACLGLANEDQASRLKEAGVDRYNHNLNTSENYHDTVVTTHTYEDRVKTVEIMKENNISPCSGVICGMGETAQDRIDMAFALKELDADSIPINFLHPIQGTKFGEMDELTPMKCLRIIAIFRLVNPTKEIRIAGGREVNLQSLQPFALLAANSIFVGDYLITGGQPNTMDYRMIQDLGFEIDCSNLPEDTAEKITETLEA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: UBC_ASFWA
Sequence: MVSRFLMAEYRHLIENPSENFKISVNENDMTEWDVILRGPPDTLYEGGLFKAKVAFPPEYPYAPPRLTFTSEMWHPNIYPDGKLCISILHGDNAEEQGMTWSPAQKIDTILLSVISLLNEPNPDSPANVDAAKSYRKLMHKEDLESYPMEVKRTVKKSLDECSPEDIEYFKNAVSNVPAIPSDAYEDECEEMEDDTYILTYDDEDEEEEDEEEEDEEMDDE
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity).  Performs the second step in the ubiquitination reaction that targets specifically a protein for degradation via the proteasome (By similarity).  By controlling the ubiquitination status of specific host proteins, the virus may target them to degradation and thereby optimize the viral replication (By similarity).  May be implicated in the shutoff of protein synthesis through its interactions with components of the host translation machinery (By similarity).  Blocks p65 nuclear translocation upon cytokine stimulation, thereby impairing NF-kappa-B signaling (By similarity).  Inhibits type I IFN production and 'Lys-63'-linked polyubiquitination of host TBK1 through binding to host RNF138.  This binding enhances the interaction between RNF138 and RNF128 and promotes RNF138-mediated degradation of RNF128 Also inhibits the activation of AP-1 transcription factor (By similarity).  Monoubiquitinates the viral protein P15/PIG1 in vitro (By similarity).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2, E2 ubiquitin-conjugating enzyme, UBCv1, Ubiquitin carrier protein, Ubiquitin-protein ligase, pI215L.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Virion. Note=Accumulates in the perinuclear cytoplasmic viral factories. Faintly detected in the nucleus.
Protein: ADDA_STRPM
Sequence: MLFNINEKGEPLVISFAPFLSPEAIKHLQENERCSDQSQKRTAQQIEAIYTSGQNILVSASAGSGKTFVMVERILDKILRGVSIDRLFISTFTVKAATELRERIENKLYSQIAQTTDFQMKVYLTEQLQSLGQADIGTMDAFAQKVVSRYGYSIGISSQFRIMQDKAEQDVLKQEVFSKLFSEFMNQKEAPVFRALVKNFSGNCKDTSAFRELVYTCYSFSQSTENPKIWLQENFLSAAKTYQRLEDIPDHDIELLLLAMQDTANQLRDVTDMEDYGQLTKAGSRSAKYTKHLTIIEKLSDWVRDFKCLYGKAGLDRLIRDVTGLIPSGNDVTVSKVKYPVFKTLHQKLKQFRHLETILMYQKDCFPLLEQLQDFVLAFSEAYLAVKIQESAFEFSDITHFAIKILEENTDIRQSYQQHYHEVMVDEYQDNNHMQERLLTLLSNGHNRFMVGDIKQSIYRFRQADPQIFNQKFRDYQKKPEQGKVILLKENFRSQSEVLNVSNAVFSHLMDESVGDVLYDEQHQLIAGSHAQTVPYLDRRAQLLLYNSDKDDGNAPSDSEGISFSEVTIVAKEIIKLHNDKGVPFEDITLLVSSRTRNDIISHTFNQYSIPIVTDGGQQNYLKSVEVMVMLDTLRTINNPRNDYALVALLRSPMFAFDEDDLARIALQKDNELDKDCLYDKIQRAVIGRGAHPELIHDTLLGKLNIFLKTLKSWRRYAKLGSLYDLIWKIFNDRFYFDFVASQAKAEQAQANLYALALRANQFEKSGYKGLYRFIKMIDKVLETQNDLADVEVAAPKQAVNLMTIHKSKGLQFPYVFILNCDKRFSMTDIHKSFILNRQHGIGIKYLADIKGLLGETTLNSVKVSMETLPYQLNKQELRLATLSEQMRLLYVAMTRAEKKVYFIGKASKSKSQDITDPKKLGKLLPLALREQLLTFQDWLLAIADIFSTEDLYFDVRFIEDSDLTQESVGRLQTPQLLNPDDLKDNRQSETIARALDMLEAVSQLNANYEAAIHLPTVRTPSQLKAAYEPLLEPIGVDIIEKSSRSLSDFTLPHFSKKVKVEASHIGSALHQLMQVLPLSKPINQQTLLDALREIDSNEEVKTALDLKKIESFFCDTSLGQFFQTYQKHLYREAPFAILKVDPISQEEYVLRGIIDAYFLFDDHIVLVDYKTDKYKQPIELKKRYQQQLELYAEALTQTYKLPVTKRYLVLMGGGKPEIVEV
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: RSXD_SALPA
Sequence: MVFRIASSPYTHNQRQTSRIMLLVLIAALPGIAAQTWFFGWGTLFQIVLAAITALVAEAIVLRLRKQSVASHLQDYSALLTGLLLAVSIPPLAPWWIVVLGTGFAIIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPYEIAATTPDILDTLRMIFSGHTASGGDMTLLRTGIDGISQATPLDTFKTSLRAGHSVEQIMQYPIYSGALAGVGWQWVNLAWLVGGVFLLWQKAIRWHIPVSFLLTLALCAALGWLFSPATLASPQLHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGVLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHRKG
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rsx electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PHOB_ECOLI
Sequence: MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGYRFSTRF
What is the function of this protein?
This protein is a positive regulator for the phosphate regulon.  Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
What are the official names of this protein?
Phosphate regulon transcriptional regulatory protein PhoB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I75A5
Sequence: MNPNQKILCTSATALVIGTIAVLIGITNLGLNIGLHLKPSCNCSHSQPEATNASQTIINNYYNDTNITQISNTNIQVEERAIRDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSCYGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPNALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: GPSB_LATSS
Sequence: MDNQLEIELNPTEILKKEFKSKMRGYDPEEVDGYLDLVIKDYQTYQENIDRLTADNTRLFNKVEELNRQLSASDSVKEVKPQQASAATNYDILKRLSNLERHVFGAKLSDQNGAAQTRVQNHSQFD
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: TAF5_SCHPO
Sequence: MSATNGPQPQDLNRIVLDYLAKKGYSRTEAMLRLEASGSGVSVEEKLKSIEETPDAYTHTYTILRDWVDSSLELYKAELHRILFPIFVHSYLNLLSQDHYEAAKQFYELFKDDHTDLHDFDVKNLKSLSLPSHVAEDRTAQQYRQNKYQLHFSRITFDLLLHFLFENVSNGGSIIIKLINQHIDIHIVPGRPTVLENAKVINEQEGITGQSFERGDAQLQPVKLQQMPMDKEMEKIVEMDLEEEDMMHQNDPNNQSPKLLKEFRKLHEPNAEDAPSRDYIPLPPHKGVDILSEVEAVKDWSKRLHLGPRASLPSVCMYTFHHTNNNMNCAEFSPDSTMIACGFQESYIRLWSIKADKKSLPKSTSVEDSDGSVRLLSHSGPVYGTTFSPDNKYLLSCSEDASARLWSVDTKTALVAYKGHTGPVWDVAFGPFGHYFATASHDQTAQLWSCDHIYPLRVFAGHLSDVDCVTFHPNSAYVLTGSSDKTCRLWDVHRGHSVRVFNGHTQPVTAVAIAPDGHTMASADSEGLIHLWDIGTGRRIKTMRGHRGNIYSLSFSRESTVLVSGGSDCTVRAWDVFKTNYNNPVSSSLTGSVVTPFSAKTSTFNEVNWSTSPDQMVALYTKQTPIFNVSFTRRNLCLAISVS
What is the function of this protein?
TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.  Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 5, Transcription initiation factor TFIID 72 kDa subunit, TAFII-72.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TAF5 family.
What are the subcellular locations of this protein?
Nucleus.