PharMolix/UniProtQA huggingface dataset:
Protein: EFCB9_HUMAN
Sequence: MRLKQGSFLWYLYLDKIYCLLSVRNVKALAEYFHILDVHGKNTLNDVLFYHFLHHVTDLKKAQINIVFDMLDWNAVGEIDFEKFYMLVCMLLAHQNHLEGQFMYRHSRPVFDLLDLKGDLRIGAKNFEMYRFLFNIQKQELKDLFRDFDITGDNRLNYQEFKLYTIIYTDKLQKRQKTEEKEKGERKRSLYSKCHIK
What is the function of this protein?
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.  pH-dependent Ca(2+) sensor required to activate the CatSper channel.  Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.  Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+).  Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 9.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, cilium, flagellum. Note=Localizes to the principal piece of the sperm tail.
Protein: ALKN_PSEOL
Sequence: MNCSLRCRFFLILVMAGFSFFVALFGMRLMHKMAEFAYFEREHVVALSKVYYELHKKEINISFIVGQVQRARRQTTAVNSLWKGDKALLRLLGKGLILELSEASEIKLGLLERYASSIYKDGLNPGHIEEMKRLVSWPYTNSNRFGIEIADISKRVKAYVYFLVVSINCLFFVVIFLLMKKTRSSIDEIVHVMNDMSRGDLTYRTIPSNDEVGKMQSSIIAMGAGVSALIESIKHIQGDLFNSAGEALNISQSTSNDICDQAGKIDEFVSALSQISFAITETSNAANKSSALSSEGRQLAVHGQKAIETAVSSINALSQRVNDSHVAIKCIEADIAKIGKIIEIIDQITDQTNLLALNAAIEAAHAGEAGKGFAVVADEVRSLAQRTNNSTYEIQAMIASLNKGIFFALGVMGDCVVESKNSVNAASEASRSIEKIVDSVSQVMLQIAQVATASEEQSAVVKDMLDNANIIREIAAGVELGSRRISEVNTHR
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.
What are the official names of this protein?
Putative methyl-accepting chemotaxis AlkN.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CSRA_SALPC
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSQQSSY
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
Protein: RL31_ENT38
Sequence: MKKDIHPKYDFITANCSCGNAIKIRSTVGHDLNLDVCGQCHPFYTGKQRDVATGGRVDRFNKRFSIPGAK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: EST3_ASHGO
Sequence: MPKVVLASRAHKADSIFLREWLVDAVVPALERSGACAPWAGVECFIPALPPATATLSLEPTVIQNPKRFLRIVRFTRVHDFAVCAVARDAGCCILVEFTPHCVSNFERRYHQRITSSTVNSLFVIGNTSLLFYARSDAAAAFEVPALMNGSSTLPVLRVGDCAIFDQDQVESHRRFPLVQEHPRFVQSLDMAMQGSVLSRYT
What is the function of this protein?
Component of the telomerase complex involved in telomere replication.  Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).
What are the official names of this protein?
Telomere replication protein EST3.
What is the protein family that this protein belongs to?
Belongs to the EST3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: NDHI_PSINU
Sequence: MFSMMNGLQHYGQQALRAARYIGQSFMVTLEHMNRLPITVQYPYEKIIPSERFRGRIHFEFDKCIACEVCVRVCPINLPVVDWELIKSMRKKQLKSYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELATYDRHELNYDQIALSRLPFSIVQDSTIQAHSSLGYLS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: Y572_TREPA
Sequence: MSALFSLVAVYVLVCALHKQIKKYASVCYLGSACVSVAVVCVVWSGATKGNFGVRVLLHPLTSASFSTAIFTFVMCASVLKNGLLKQRVMGLRAELAITAAILTLGHNIAHGRDYLVRLCGSTGDLSTGFLVAGAVSMVLVLLMSILAVTSFKVVRRRMGAKTWKRVQRLAYLFYGLTYVHLSFILLPTALRGYIPSVVSYVLYTVIFATYALLRVRKALGKRKGACALCSAAVAVSFVAFVLGASHMVRHTRRAHTERTTRAKARKCSPAEMKDGVYEASAQGHNGKLSLRVTISQGRIEAVTVVGHSDDDPYASWAVEGVSAAIVGAQSTDVDVVSEATSTSEAIIRAVEKILQQPQP
What are the official names of this protein?
Uncharacterized protein TP_0572.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MDH_PSYIN
Sequence: MKIAVLGAAGGIGQALALLLKLDLPANSILSLYDLAPVTPGVAKDLSHIPTSVKVEGFAGTDPTAAIEGADVILISAGVARKPGMDRSDLFNINAGIIKNLVAKVAEVAPEACIGIITNPVNTTVAIAAEVLKAAGVYNKNKLFGITTLDVIRAEEFVAELKGLPSEDVRVNVIGGHSGTTILPVLSQIQGVSFTDQEVIDLTSRIQNAGTEVVEAKAGGGSATLSMACAASRFAIQLVHALSGKQGIIQNAYVDGGNPASPFFTQPLLLGKNGIDKVLPYGELSSFEETKKEEMLSVLHADIEMGIDFVSKTLAAEVS
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: RUG2_LIMKU
Sequence: MFTMKKSLLFLFFLGTISLSFCEGERSADEDDEGEMTEEEKRSIRDKGKTIAIDLAKSAGTGVLKTLMCKLDKSC
What is the function of this protein?
Has antimicrobial activity against Gram-positive bacteria S. aureus ATCC 2592 (MIC=10. 0 uM), S. aureus ATCC 43300 (MIC=10. 0 uM) and B. subtilis (MIC=30. 0 uM), against Gram-negative bacteria E. coli ML-35P (MIC=10. 0 uM), P. aeruginosa PA01 (MIC=2. 5 uM) and P. aeruginosa ATCC 27853 (MIC=2. 5 uM) and against fungus C. albicans ATCC 2002 (MIC=10. 0 uM).
What are the official names of this protein?
Rugosin-LK2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: WTR38_ARATH
Sequence: MSMEEISSCESFLTSSKPYFAMISLQFGYAGMNIITKISLNTGMSHYVLVVYRHAIATAVIAPFAFFFERKAQPKITFSIFMQLFILGLLGPVIDQNFYYMGLKYTSPTFSCAMSNMLPAMTFILAVLFRMEMLDLKKLWCQAKIAGTVVTVAGAMLMTIYKGPIVELFWTKYMHIQDSSHANTTSSKNSSSDKEFLKGSILLIFATLAWASLFVLQAKILKTYAKHQLSLTTLICFIGTLQAVAVTFVMEHNPSAWRIGWDMNLLAAAYSGIVASSISYYVQGIVMKKRGPVFATAFSPLMMVIVAVMGSFVLAEKIFLGGVIGAVLIVIGLYAVLWGKQKENQVTICELAKIDSNSKVTEDVEANGSKMKISEGDNSMLSTIVISVPLSETHLKKTIQEP
What are the official names of this protein?
WAT1-related protein At5g07050.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MNTH_SHIB3
Sequence: MTNYRVESSSGRAARKMRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELIFSQPNLAQLGKGMVIPSLPTSEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGSRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGVADLDEAYLTLQPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFIRFHIPLWVRRTVTMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSDSKLMGDLVNSKRVKQTGWVIVVLVVALNIWLLVGTALGL
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NANA_CITK8
Sequence: MAKDLRGVMPALLTPFDNQQKLDIESLRRLVRFNIAQGIDGLYVGGSTGEAFVQSRAEREQVLEIVAEEAKGKVTLIAHVGTVSTEESQQLASAAHRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSAEGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRRAHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALQEGDVAKAQHLQTECNKVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFSPVDEKYLPELKALAQQLMQERG
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_METHJ
Sequence: MNSRPLLVTCGLPYTNGPCHLGHLRTYVPADFYVRFMRRKGEEVVFICGSDNHGTPIVVSAEKEGTTPRQISERYHTHFSDTFTKMQVHFDHFGMTDDPTTHARTKHLVSRLIDRGYVYPKVIQQAYCIHCQKFLPDRYLEGICPHCKKPARGDECDQGCGKHLEPGEILEPTCKICGNRAEYREQEHFFFKLSGFQDWLREYLGELKGTDNAINYALGWVNEDLHDWCITRTLEWGVKFPGHDDLVVYVWVDAPIGYIGFTEEWAEKTGRDWKTYWCGENTRVTHFIGQDITYHHCVFWPAMLHGAGYGTPYAVVASGMLKIDDHKFSKSRGYVVWTNEDYLDQGLPADYLRYYLLSYTSHTKEMNFSWQLFQERINNEVVNNLGNFIYRSLHLSQKQFGGVPEGVVEQEIFDRITEAIGQVTGLVEAYDFKGAVDAILALSAWGNTYIQSKEPWKLAKTDQAAMAQVMRNCLQLAKALTLLIEPVMPERAGLIWSQLGQDSLIANNGFSAGLEPLSPGPLPAPSIVFSKIDDKMTQELDKRLRDRIDALDAEKKPKTPEISIEEFAKVEMKTGKILSAEQVPKSTKLLKLQVSIGDEVRQIVSGIAQFHNPEELVGKDVVVCTNLKPAKIFGIESNGMILAAGDNASLLRPETPVPSGTKIR
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_STRP2
Sequence: MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSVNQPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDLLSEYDFPGDDLPVIQGSALKALEGDSKYEDIVMELMNTVDEYIPEPERDTDKPLLLPVEDVFSITGRGTVASGRIDRGIVKVNDEIEIVGIKEETQKAVVTGVEMFRKQLDEGLAGDNVGVLLRGVQRDEIERGQVIAKPGSINPHTKFKGEVYILTKEEGGRHTPFFNNYRPQFYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGMVTEIEA
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RING1_RAT
Sequence: MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPMPGSDQTTTMSGGEGEPGEGEGDGEDISSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGAAGGACGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQETVEPGGPGGGASDTGGPDGGGGERGVSGGGEGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
What is the function of this protein?
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation.  H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.  Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.  Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RING1, Polycomb complex protein RING1, RING finger protein 1, RING-type E3 ubiquitin transferase RING1.
What are the subcellular locations of this protein?
Nucleus speckle.
Protein: Y1633_METJA
Sequence: MMNMITVIGFGSFGRKVVNFIKNKEPITIIDKNIDDADDLVKEGVTVIVGDATQDEVLKKAKIENADIVLILTNEPEVNRRIAERVCELSPNSYKIARAIPRYPELYMGLNIDKIINILESGAKDIAKEVEDAKLKRKLMQLKSVLIEGKKRCMKLEKTEEEKKAPLLILTHINPDPDAIASAMALKTLAERWGVDSDIAYGGNIGYDENKAMINLLGIKLLNVEDIDLDNYCVIAVIDTSTSKQLPIELPNIDIIIDHHNNTDLTAKYMDVRPEVGATASILTQYLMELDIEPSRNLATALFYGIQSDTDYFKRETSKLDFEAAAYLQSYIDASILNMIENPEISTEVMEVLAKAVMNRRVVKGNIALAYVGEISNRDALPKAADFLLKMEGISTTFVFGIVGDEIHISARTKDLRLNLGEILNKAFGGGGHQTAAAAKIPLGIFKAVSDKEALRKLVEEAIRAKILEVIGIKEEEK
What are the official names of this protein?
Uncharacterized protein MJ1633.
Protein: RR2_PLAOC
Sequence: MTRRYWNINLEEMMEAGVHFGHGTRKWNPRMAPYISAKRKGIHIINLTRTARFLSEACDLVFDAARRGKRFLIVGTKNKVVDLVASAAIRARCHYVNKKWLGGMSTNWSTTETRLHKFRDLRAEQKAGRLNHLPKRDAAMLKRQLSHLETYLGGIKYMTGLPDIVIIVDQQEEYTALRECVTLGIPTICLIDTNCDPDLADISIPANDDAIASIRLVLNKLVSAICEGRSSYIRNH
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: QUEF_PARDP
Sequence: MTETIYSGLKQLGGATLLPESPDKAELERVRNPQADVAYNVRFTAPEFTSLCPMTGQPDFAHLVIDYVPGEWLVESKSLKLYLGSFRNHGAFHEDCTVSIGRRLAGFLAPRWLRIGGYWYPRGGMPIDVFWQTGPMPEGVWIPDQDVPPYRGRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNB_ECOBW
Sequence: MSEFLPFSRPAMGVEELAAVKEVLESGWITTGPKNQALEQAFCQLTGNQHAIAVSSATAGMHITLMALKIGKGDEVITPSLTWVSTLNMISLLGATPVMVDVDRDTLMVTPEAIESAITPRTKAIIPVHYAGAPADIDAIRAIGERYGIAVIEDAAHAVGTYYKGRHIGAKGTAIFSFHAIKNITCAEGGLIVTDNENLARQLRMLKFHGLGVDAYDRQTWGRAPQAEVLTPGYKYNLTDINAAIALTQLVKLEHLNTRRREIAQQYQQALAALPFQPLSLPAWPHVHAWHLFIIRVDEQRCGISRDALMEALKERGIGTGLHFRAAHTQKYYRERFPTLSLPNTEWNSERICSLPLFPDMTTADADHVITALQQLAGQ
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: NUP1B_XENLA
Sequence: MADIPENAPQHCPGTGSTEAGKSSACQGCPNQSICASAATSAPDPAIEEIKEKMSLVKHKILVLSGKGGVGKSTFSAHLAHGLAQDEGKEVALLDVDICGPSIPRMMGLEGEQVHQSGSGWSPVYVEDNLAVMSVGFLLSSPDDAVIWRGPKKNGMIKQFLRDVDWGEVDYLIVDTPPGTSDEHLSVVQYLSAAGIDGAVIVTTPQEVSLQDVRKEINFCRKVKLPIIGVVENMSGFICPKCENESQIFPPTTGGAEKMCTDLNVSLLGKVPLDPNIGKSCDTGKSFFTEIPDSPATLSYRIIIQRIQDYCEKKK
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor nubp1-B, Nucleotide-binding protein 1-B, NBP 1-B.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SE6L2_HUMAN
Sequence: MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVESDFSNPLYEAGDTREYEVSI
What is the function of this protein?
May contribute to specialized endoplasmic reticulum functions in neurons.
What are the official names of this protein?
Seizure 6-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the SEZ6 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Detected on cell surface of lung- cancer.
Protein: FABH_DESVV
Sequence: MTSPSLLRGFGAYAPERILTNADIESMVETTDEWITTRTGIRQRHVVAPGQTTSDLAVEAARAALADAALDTADITHVLVATCTPDASCPNTACIVARKLGMTGVMALDCNAACSGFLYGLELAQGIVAARPASRVLLVAAEALSLRCNWKDRTTCVLFGDGAGATVVTADVDATQGTAVLEDSIVTSDGSLGDLLTIGGGTANPYAIGDSVGEEYFVRMQGRDVFKHAVRSMTQVCNDLLARNGFTTEDVDLVIPHQANLRIIEAVGDRLGFASEKVFVNVHDFGNTSAASIPLALADARAQGRIRPGMRVLLTTFGGGFTWGAALLRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAG1_XENLA
Sequence: MEVALPNVPTKMQHPFTKYSEWKFKLFRVKSLERRPSEEETEGSEVSYNSSQETYPKSTVVLEDLSLGSAPQSPTNFKPQQSEKSNVVDNHETDLKRLEEEAHITVIQQLCRICGASFKMDQQNRSYPVHGPVDSETHDILRRREKKVTSWPELISKVFKTDVRADVDTIHPTQFCHNCWTIMNQKFSNISSEVYFPHNQAVEWTPHSANCYVCHSSKPWGKRKSAPQLNPHKMKKRKRGPEFVKKSKTSSGNSIQWKNMKAFNQMKDSCKKIHLDNNLLVLDYPSDFVKSVSCLVCEHILSDPVQTSCKHLFCRICILKYIKLMGCYCPSCKYPCFPTDLTVPVKSYLNVLNALLLKCTVSGCDEEISLGKYSHHISKHKETKGKEVYAHINKGGRPRQHLLTLTRRAQKHRLRELKMQVKAFADKEEEGDVKSVCLTLFLLALRARNEHRQADELEAIMEGRGAGLHPAVCLAIRVNTFLSCSQYHKMYRTVKATTGRQIFQPLHALRNAEKALIPGYHTFEWRPPLKNVSTRTDVGIIDGLSGLNQSLDEYPVDTISKRFRYDAALVSALKDMEEDILEGLKAQDLDDYVSGPFTVVVKESCDGMGDVSEKHGSGPPVPEKAVRFSFTVMNISVPNKNGPVRIFEETKPNSELCCKPLCLMLADESDHETLTAILSPLIAEREAMKTAELLLEMGGILRNFKFSFRGTGYDEKLVREVEGLEASGSLYICTLCDATRLEAAQNLVNHSITRSHCENLQRYEMWRSNPHHESPDELRDRVKGVSAKPFIETLPSIDALHCDIGNAAEFYRIFQLEIGELYKNLSATKEEKKRWQATLDNHIRKRMNLKPIMRMNGNFARKLMSKETVEAVCELVPCEERQAALTELMDLYLKMKPVWRSSCPAKECPELLCQYSFHSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWASEGNESGNKLFRRFRKMNARQSKFYEMEDVLKHHWLYTSKYLQKFMNAHNNLKNQGFTVDLDNPDLEQRLESSMESLESMEF
What is the function of this protein?
Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination.  V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments.  In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment.  RAG2 is not a catalytic component but is required for all known catalytic activities.  DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.  In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3.  Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity).
What are the official names of this protein?
V(D)J recombination-activating protein 1, RAG-1.
What is the protein family that this protein belongs to?
Belongs to the RAG1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PA2A2_NAJAT
Sequence: MTPAHLLILAAVCVSPLGASSSRPMPLNLYQFKNMIQCTVPSRSWWDFADYGCYCGRGGSGTPVDDLDRCCQVHDHCYNEAEKISGCWPYSKTYSYECSQGTLTCKGGNNACAAAVCDCDRLAAICFAGAPYNNNNYNIDLKARCQ
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 2, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YEGP_SHIFL
Sequence: MAGWFELSKSSDNQFRFVLKAGNGETILTSELYTSKASAEKGIASVRSNSPQEERYEKKTASNGKFYFNLKAANHQIIGSSQMYATAQSRETGIASVKANGTSQTVKDNT
What are the official names of this protein?
UPF0339 protein YegP.
What is the protein family that this protein belongs to?
Belongs to the UPF0339 family. Duplicated subfamily.