PharMolix/UniProtQA huggingface dataset:
Protein: RNH2_COLP3
Sequence: MASKQIFPDFEYPIAYCIAGVDEVGRGPLVGDVVTAAVILDPDNPIEGLMDSKKLSEKKRNLLSLEIKEKAISWSLGRASPQEIDTLNILHATMLAMQRAVEGLNVEPDFVLVDGNRCPTFLCNASESNQQNLKIASQAVVKGDARVTEISAASIIAKVARDNEMIALDKLHPEYGFAKHKGYPTKLHLEKIIEHGVLDCYRQSFKPVARVLGTYHD
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_PSYIN
Sequence: MFDIGFWELVLISVIGLVVLGPERLPHAIRSVMHWITTAKNMANSVKTEVTQELKLHEINENMIKASKQGLSDLDPELQKSIDEMKETAEQLSRPYKKDIDDIKTSLDKNPSGTTQQENSILDSSKTTPPRQDKNE
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TPIS_STRPF
Sequence: MLRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVLKVAAQNCYFENTGAFTGETSPKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFANGLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQVASLVLAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLEADSFLALLDFLN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_MICAN
Sequence: MKGIFIGLIEGYRRFISPLFPPSCRFQPTCSQYAMEAIDRFGVLRGSWLAIKRILRCHPFHPGGYDPVPPCHHKHD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MTRH_METKA
Sequence: MFYYPGKEQKVCDICGVKVGGQPGEYPTVLAGTIFYAGHKIVKDEDKGIFDEEAAEELIKMEEELADETGNPMMAHIMGESEEAIIRYLDWVADVTDAPIIVDSTEAEVKVAAVKHAQEVGLAERVVYNSINASVEDEEIQAIKESDCNSAIVLAFNPMDASVEGRMKILTEGEEGVSEKGMLEISDECGIENPLIDTAYTPFGSGAGTAYKVTLAVKAKLGLPVGGAPHNVPSAWDWLRDFMKKLKEEGKEEWAELAHESSDWGSNVVAATLCCDYLLFGPIENAPAIWPVVAMVDALIVEANEDVGVEPQVEEHPANIVR
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.  MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit H, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H.
What is the protein family that this protein belongs to?
Belongs to the MtrH family.
Protein: ATP25_KLULA
Sequence: MHRSYAVLLRNNVARLCYRPGSTLFIRNFTTRHSLRQSKPWYLDISENKEEDSNSPFIKPIRFPPTEIPASLETISKYLNDKLAVTDIVVFDTAHSSSATSIQSMASYVLIGTVKSFRHLQNCNDELIKFIKETFDEVPKSEGLVTSGILRKRQRRLGRKTNLGKIAKIENDESGWCLIDSNVDGLFINIMTEERRDDLNLEELYCRVEELDQYKKQINLNPPAEEEDDVLLGLRKLMMKNTKRYYSTVGESPKPTFLEALTIQDLDSASKLIKEEKKPYHVIASALGRLPNHIELDAENWIKLFNEATPTEGPLDYEYWGARFKFFQLLYISKRNNIEENTQLDASTIKEFNRELNYFINDFFRFKQLALCQPTREELIGFLEICIQHLKLSKSYNQLISVNMWILKALQSYQYSDPKVVHDPRVIKLLVKSMHTENTNLNSLYEYVNLITNEFEVRSLTNDVIKEIITTLVESENWPTLFKFWKQCLCESAVDSNVWDFFIKSLLNKNDKVILSDIVDNGHLLWIHRSKLVISDDLKASLSKLLDRVDGSHTNIKKLLKL
What is the function of this protein?
Probable mitochondrial mRNA stabilization factor.
What are the official names of this protein?
ATPase synthesis protein 25, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATP25 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: HPF1_BOVIN
Sequence: MVGGGAKRRLRGEGPQCEKPVDMKKSKSCEADVPGDLRKEVESHYRLPLPEDFYHFWRFCEGLDPEQPADSLSASLGLRLVGPYDILAGKHKIKKKSASLNFNLHWRFYYDPPEFQTIIIGDSKTQFHMGYFRDSPDELPVFVGTNEAKKNCIIVQSGDNVFAAVKLFLMKKLKEVTDKKKSSLLKTIDEKLTEAARELGFSLEQRTVRMKQRDKKVVTKTFHGAGLVVPVDKNDVGYRELPETDASLRRICGTIVEAPSDADRLQAFAPVQEMMTYVQFANDECDYGMGLELGLDLFCHGSHYFHKVAGQLLPLAYNLLKRNLFAEIIEAHLANRSQDDVDQLAA
What is the function of this protein?
Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response.  Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins.  Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks.  Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage.  HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2.  While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains.  HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1.
What are the official names of this protein?
Histone PARylation factor 1.
What is the protein family that this protein belongs to?
Belongs to the HPF1 family.
What are the subcellular locations of this protein?
Chromosome. Nucleus. Note=Localizes to DNA damage sites; chromatin localization is dependent on PARP1 and PARP2.
Protein: CISD2_DROPE
Sequence: MEPISHVVKSSLPNYLSSLPIPDSFGGWFKLSFKDWLALIPPTVVVAGLGYTTYLAFCPAARCAGKDSGRCNSSIRKNEAKVVTMVDVEDIAGQAAFCRCWKTKNWPYCDGSHGEHNKQTGDNVGPVVVKKK
What are the official names of this protein?
CDGSH iron-sulfur domain-containing protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the CISD protein family. CISD2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: DPOL_ASFB7
Sequence: MISIMDRSEIVARENPVITQRVTNLLQTNAPLLFMPIDIHEVRYGAYTLFMYGSLENGYKAEVRIENIPVFFDVQIEFNDTNQLFLKSLLTAENIAYERLETLTQRPVMGYREKEKEFAPYIRIFFKSLYEQRKAITYLNNMGYNTAADDTTCYYRMVSRELKLPLTSWIQLQHYSYEPRGLVHRFSVTPEDLVSYQDDGPTDHSIVMAYDIETYSPVKGTVPDPNQANDVVFMICMRIFWIHSTEPLASTCITMAPCKKSSEWTTILCSSEKNLLLSFAEQFSRWAPDICTGFNDSRYDWPFIVEKSMQHGILEEIFNKMSLFWHQKLDTILKCYYVKEKRVKISAEKSIISSFLHTPGCLPIDVRNMCMQLYPKAEKTSLKAFLENCGLDSKVDLPYHLMWKYYETRDSEKMADVAYYCIIDAQRCQDLLVRHNVIPDRREVGILSYTSLYDCIYYAGGHKVCNMLIAYAIHDEYGRIACSTIARGKREHGKYPGAFVIDPVKGLEQDKPTTGLDFASLYPSLIMAYNFSPEKFVASRDEAKSLMAKGESLHYVSFHFNNRLVEGWFVRHNNVPDKMGLYPKVLIDLLNKRTALKQELKKLGEKKECIHESHPGFKELQFRHAMVDAKQKALKIFMNTFYGEAGNNLSPFFLLPLAGGVTSSGQYNLKLVYNFVINKGYGIKYGDTDSLYITCPDSLYTEVTDAYLNSQKTIKHYEQLCHEKVLLSMKAMSTLCAEVNEYLRQDNGTSYLRMAYEEVLFPVCFTGKKKYYGIAHVNTPNFNTKELFIRGIDIIKQGQTKLTKTIGTRIMEESMKLRRPEDHRPPLIEIVKTVLKDAVVNMKQWNFEDFIQTDAWRPDKDNKAVQIFMSRMHARREQLKKHGAAASQFAEPEPGERFSYVIVEKQVQFDIQGHRTDSSRKGDKMEYVSEAKAKNLPIDILFYINNYVLGLCARFINENEEFQPPDNVSNKDEYAQRRAKSYLQKFVQSIHPKDKSVIKQGIVHRQCYKYVHQEIKKKIGIFADLYKEFFNNTTNPIESFIQSARFMIQYSDGEQKVNHSMKKMVEQRATLASKPAGKPAGNPAGNPAGNALMRAIFTQLITEEKKIVQALYNKGDAIHDLLTYIINNINYKIATFQTKQMLTFEFSSTHVELLLKLNKTWLILAGIHVAKKHLQALLDSYNNEPPSRTFIQQAIEEECGSIKPSCYDFIS
What is the function of this protein?
DNA-directed DNA polymerase involved in viral DNA replication.
What are the official names of this protein?
DNA polymerase beta.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
Protein: RL33_ACTPJ
Sequence: MAAKGNREKIRLVSSAETGHFYTTTKNKRNMPEKMEIKKFDPVVRKHVIYKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: TYW4_MOUSE
Sequence: MGPRGRQRRAGTVQSTNDSSSLSKRSLAAHGYVRDPFAALLVPGPVRRTPLIHRGYYVRARAVRHCVRAFLELTSALPSRTRAQILSLGSGSDSLYFRLKAAGLLARAAVWEVDFPDVSRLKAERIEETPELRAQTGPFKIGDSASSLCFESADYRILGADLRELQRLGEALDGAGLDATSPTLLLAEAVLTYLEPSSATALIAWAAQRFPDALFVIYEQMQPGDAFGQIMLQHFQRLHSPLHGLELFPVVKAQRQRFLQAGWTACSALDLNEFYRRLLSAEERQRVETLEPFDEYEEWHLKCSHYFILAASRGDILSETPVFEPSEASFQIDPASPSGFLSARVVTSDHQHSSLKRYGHASALLSPGVIFSAGGFGEQEGRHCRVSRFHVLSRSCDSEWEGCQISTLGTEGQWDGRLYHTMTRLSDTRVLVLGGRLSPVSPASGALQLDLYKSKDNCSEGQNVTVTKAALEEGSVLSCWRHSTTEVYYQNQRYLFVYGGRSVAEPVLSDCRFLHVETMAWVRIPVQGASPEGRHSHSACSWQGGALIAGGLGASEELLSSVLFLKPVSSGFLWESIDIQPSITPRYSHTAHVFNGKLLLVGGVWIHSSSVPGVTVICLTTGLSSEYQIDTASVPWPLMLHNHSSALLPEEQQLLLIGGGGNCFSFGTYFNPHTVALDLSSLRSGQ
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).  May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 4, tRNA yW-synthesizing protein 4, Leucine carboxyl methyltransferase 2, p21WAF1/CIP1 promoter-interacting protein, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.
Protein: Y2938_METRJ
Sequence: MTGALPDGADRRRAAYRFGHRAEWLALAALMLKGYWPIGRRVSVAGGEIDLVVRRWNTVVFVEVKARAKRDDAREAIDGAKRRRFSRAVRAWIGRNAWCAGATFRADAVFVGHWAWPAHVERVFTIEGL
What are the official names of this protein?
UPF0102 protein Mrad2831_2938.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: PSD_SALCH
Sequence: MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMTEAQKPDTASYRTFNDFFVRPLRDDVRPLNTDPNILVMPADGVISQLGRIEEDKILQAKGHNYSLEALLAGNYLMADKFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPEGEHEGSVALLKGQEMGRFKLGSTVINLFAPGKVNLIASLASLSVTKIGQPLATSTETFVAPEVEPAPLPAEEIKAEHDASPLVDNKKDDT
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TRM44_DROME
Sequence: MAAVEEAQFWQAIGILIKNYHALNKKIFEVVITQVTKQQNGRVCESSAEELAMSLKEDPSQRTCTGFTIGFKLLSKKLAENILGTGIVDFENCLYECQFASDSIEGFSVGLLGGEFKLKSKSNTNWLEFVLRPKLLSWSQSKQDEAKVKSLGLVNVEKYNDLYKELKQRHSQRLLEHWKTAQESTDPLKFIYEDLAIAAYLIVLWSQTQSEPTAFADLGCGNGLLVHVLNAEGYKGYGYDIRKRKLWSLYPPDTQRSLIEKAVEPNSFRLDFPGVDWLIGNHSDELSPWLPVLAGRLNINYFLLPCCPFELSGAKFRRRNTKISAYQDFFQYVTQVSHECGYEILQDRLKIPSTKRLALLGIKRKASKAIEDLEYFVQEELRKYKTGDAKIKLREKEESVRNCTQVDKTIIDGLVFKIFKLILDSNEDKWSGRLPMREIAQALTKEELSGIKSECGGIKTLLRNKHEVFEFCGGDLIGIRTPKPTATLPKSHLTIKKRSCFFKLHHPLGCPLDDAECSFIH
What is the function of this protein?
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
What are the official names of this protein?
Probable tRNA (uracil-O(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TRM44 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP28_EMENI
Sequence: MESQSILPPPPPPEDASAPPPPPEESAAPPPPPDVSAPPPPPEDLPPPPPEPEVKKKKVGWGTKRPATTPLSVEELVRKKREADAAAARPKFMSKAERERLALEKRAKEVDAQRRRTNGTPNGVDGMDLDTPSRGFRTPNGDSRSIPTGPRAMRNGDGPTPTGPAAMRSRNDSGTTKSDKKVDKRFNEEDEAAAQAALIKQRYMGADQTSNFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQHRHEANFFGRGRLAGFGDDVADSVAKKYAKALEDRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNIATKGGSVPNPMRSWDESGLPKRLLELVDRVGYKEPTPIQRAAIPIAMQSRDLIGVAVTGSGKTAAFLLPLLCYIAELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEAKKFTEPLGFNVVSIVGGHSFEEQAYSLRNGAEIIIATPGRLVDCIERRMLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVTNEKPDTEEAEDSSAMSRHLGSKDRYRQTMMYTATMPTAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLGEILSSGDFRPPIIVFVNIKRNCDAIAREIKQWGFSSVTLHGSKTQEQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVINFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLIKSPISRVPEELRKHEAAQSKPTRGAGKKIEEASGFAGKGGW
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA splicing.  May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site.  May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing ATP-dependent RNA helicase prp28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AMPL_PLAF7
Sequence: MYFSSLCKFLPISEKEKIYLNIVKKRFCKSNIYYNNNNNNIINYNKRGLKFYPFCNNLKKNINFVNINNKKGINFHSINKERKMASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKNVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILNSSKTSNEPVWWLPIINEYRATLNSKYADINNISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLNDAL
What is the function of this protein?
Aminopeptidase which preferentially cleaves leucine residues from the N-terminus of peptides (PubMed:17107951, PubMed:22359643, PubMed:34133730, PubMed:33536500, PubMed:21844374).  Also, has some activity towards tryptophan and methionine and to a lesser extent towards phenylalanine (PubMed:17107951, PubMed:22359643, PubMed:34133730).  Has very low activity or no activity towards the other amino acids (PubMed:17107951, PubMed:22359643, PubMed:34133730).  In addition, cleaves the Cys-Gly dipeptide, probably as part of the glutathione regulation pathway; cleavage only occurs in the presence of Mn(2+) (PubMed:33303633).  During the asexual blood stage, plays a role in the final step of host hemoglobin catabolism, by cleaving hemoglobin-derived oligopeptides providing a source of amino acids for the parasite protein synthesis and for the maintenance of osmotic homeostasis (PubMed:34133730).  During the asexual blood stage, may also play a role during the ring-trophozoite transition (PubMed:21844374).
What are the official names of this protein?
Leucine aminopeptidase, PfLAP, M17 leucyl aminopeptidase, PfA-M17, PfM17LAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
Protein: MTNN_BACAH
Sequence: MRIAVIGAMEEEVRILRDKLEQAETETVAGCEFTKGQLAGHEVILLKSGIGKVNAAMSTTILLERYKPEKVINTGSAGGFHHSLNVGDVVISTEVRHHDVDVTAFNYEYGQVPGMPPGFKADEALVALAEKCMQAEENIQVVKGMIATGDSFMSDPNRVAAIRDKFENLYAVEMEAAAVAQVCHQYEVPFVIIRALSDIAGKESNVSFDQFLDQAALHSTNFIVKVLEELK
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: SSRP_CARHZ
Sequence: MEKIIAENRKAYHDYHILEKYEAGIALKGTEVKSIRLGRVNLRDSFARIENGELWLYNMHISPYEQGNRFNHEPKRPRKLLMHKREIMRLFGKTREKGLTLVPLKLYFKGNYAKIELGLAKGKKIYDKREEMAKRDAAREIEKALRARY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PANB_RUTMC
Sequence: MNIEALNNFKQSGEKITCLTAYDASFASVFDVCGIDIILIGDSLGNVIQGGENTLNVSMDDMVYHTKAVTKGAQNALRISDMPYQSYTNSEQALTNAKLLIIAGAQMVKFEGGCEHEASFKIFQNNDIPVCGHLGLQPQSVIEMGGYKTEGRDKQSADKIIKDALALASWGVKVIVLECIPANLAKQVSQSLSIPTIGIGAGVNCDGQILVSYDMLGIHVGYVPKFVKNFLIDSGDIKSAVNAFIEAVKDKSFPGEQHSY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_PONAB
Sequence: MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Required for pre-rRNA processing and maturation of 40S ribosomal subunits.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).
What are the official names of this protein?
40S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS19 family.
Protein: XKR9_TETNG
Sequence: MTEFTKLRWLLSAAGLVMYVADVCTDAALVLTYFKEKHVVCAALTLLFIVVGLLVTQVFSTAWYWDDMDCDEKREDMKTTLPVVSKRGLATLHLFGVGIFIRYYQMLKRGFGVAWGTVEPVEEIKNQQHFLFGLAADLSMLRLLEAFLESVPQLLLQLYIVLGQQECSLVQLVGMSFSFMNAAWALVDYRRCLRRSLPDVRQMPRGLPTAIYLLYKLFTITSRVLGYALLLIFSIYSTVGLAIVWLLGTAWTHRLHTDFCSSQSLEFLYRAIVGVILTFTFFNVKGQGTRDAMITYYFLHSLINVLSLLLLFVLRPDLLTLAALLCVSTLMAACSVLGLVCLVLYYLLLHPTEACREADEVDGLEIKTRSKGRLRDFLYP
What is the function of this protein?
Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface.  Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment.
What are the official names of this protein?
XK-related protein 9.
What is the protein family that this protein belongs to?
Belongs to the XK family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ENGB_MESH7
Sequence: MVKCKLFFWLISWFLKVKNVEKVWKFLKSCPENCYSDPQFAFIGRSNVGKSTLINALANKKIAKTSTKPGRTQLLNFYKNESEKLFVDLPGYGYAAVSKTKKHQIDRIIAGYFQKDQPISAVFLILDARVGFTNLDYIMIEYIIQQGFKLHILANKIDKTNQSTRAILLNQCKKLKLNCLLISAKNKNNLSKLQELLE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MNTP_CLOAB
Sequence: MNIYSLFVVAIALSLDAFGVALSIGLDSCVKRKNKLLFAISFGFFQFLCTFIGAYSGFLFNTYITYVPQIIGGMIIAFVGAFMIKEGFDNKEEKLLLNFKMYFVLGISVSIDAAVVGFTMFNKISSNYVILGDSVFIGIVTLILSIIAFIISRYLKRIQLVCKYADYIGGIILVIFGLKMMFF
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ANM3_SCHPO
Sequence: MLVKPMACYFEIWTRKVTTIEDFSLAIANRFKQMGSHSDSEVDWDNEEEVWEDEVHEFCCLFCDSTFTCLKDLWSHCKEAHNFDFYQVKQQNNLDFYACIKLVNYIRSQVKEGKTPDLDKLSDILRSDEYMISVLPDDSVLFSLGDELDSDFEDDNTLEIEVENPADVSKDAEIKKLKLQNQLLISQLEEIRKDKMNELTSQTTDQLSVTPKKADNDSYYFESYAGNDIHFLMLNDSVRTEGYRDFVYHNKHIFAGKTVLDVGCGTGILSMFCAKAGAKKVYAVDNSDIIQMAISNAFENGLADQITFIRGKIEDISLPVGKVDIIISEWMGYALTFESMIDSVLVARDRFLAPSGIMAPSETRLVLTATTNTELLEEPIDFWSDVYGFKMNGMKDASYKGVSVQVVPQTYVNAKPVVFARFNMHTCKVQDVSFTSPFSLIIDNEGPLCAFTLWFDTYFTTKRTQPIPEAIDEACGFTTGPQGTPTHWKQCVLLLRNRPFLQKGTRVEGTISFSKNKKNNRDLDISVHWNVNGKADSQSYVLN
What is the function of this protein?
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in ribosomal protein rps2.
What are the official names of this protein?
Ribosomal protein arginine N-methyltransferase rmt3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_XANOP
Sequence: MAITQNYGTGRRKSSTARVFLRKGTGKITVNDRPLDEFFGRETARMIVRQPLELTKNTESFDILVTASGGGTTGQAGAIRLGIARALVEYDETLKSELRKAGFMTRDAREVERKKVGLHKARRATQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: AAEX_ECO8A
Sequence: MSLFPVIVVFGLSFPPIFFELLLSLAIFWLVRRVLVPTGIYDFVWHPALFNTALYCCLFYLISRLFV
What are the official names of this protein?
Protein AaeX.
What is the protein family that this protein belongs to?
Belongs to the AaeX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.