Protein: PHMA_PHANO
Sequence: MGSSSKDYTNEPIAIVGSACRFPGGASEPSKLWDLLEHPTDVLKEIPESRFSVDGFYHPNGLHHGTTNVRHSYILDDDIRLFDAQFFGIKPIEANSIDPQQRLLMETVYEGLEAAGQSIQRLQGSQTAVYVGLMSSDYKDLLGNDQESYPTLVALHQAVQLLRSGDGTNVALAAGTNLLLNPDQYIAESKLKMLSPDGRSRMWDEKANGYARGDGIAVVVLKRLSQALEDGDHIECLIRETQINQDGKTKGITMPSATAQTALIRATYAKAGLDLSKPSDRPQYFEAHGTGTPAGDPIEAEAIHTAFFGGDLGEAGHDKLFVGSIKTVIGHTEGTAGLAAVLKASLALQNRAVPPNRLFDRLNSKIRPFYGDLEILTKAQEWPVLVPGSVARASVNSFGFGGANAHAILEAYEPPSLVSDDVLVTPLAPVQFSAASETALRGTLRKYAEFLEKNQDVNLRDLAWTLNTRRSVLAARTAVFGANALDLAHELQKRAEADVATLIPVASRSLPAKPRILGVFTGQGAQWARMGAELLDASPAVDRIISELEKSLSTLPDGPEWSVKGEILATGGASRVAEAAISQPLCTAVQIVLVDLLKSAGINFEAVVGHSSGEMGAAYAAGYLSAQDAIRVAYYRGRHLHLAGGLGGEQGGMMAVGTSFEDAEELCSLPEFQGRIGVAAINSGASVTLSGDLDTIEAAKEILDDEKKFARLLKVDKAYHSHHMIACSDAYRKSLADCSIKVLRPSRGSATWLSSVYGEDIVDYRKELTSEYWINNMVRPVLFSQAVEFAAAEKGPFDCAIEVGPHPALKGPALQVLQEFLGNSIPYTGLLSRDRDDKKAFAEGLGYLWQAFGENAIDHKSFDTFVAGASAPLPQITSNLPTYAWDHDRRFWHESRQYAANRTKPDPTHELLGTKCPDGTEQQCRWRNMLRPQEIPWLAGHQIQGQMVFPAAGYVSAAVEAVKFSNEGLPITTIEIEDFVIGQAIIFNDDYASVETQFTLTNIVSDHMSWSASFAFYSASQKHSLGMDLNASGRISALFGPPKDDVLPPSTGRELNMIDVDPEQFYNSLSKLGFGYTGAFKALRNLYRKMDVAMGEIQNPRSTDPAYNLLLHPATFDNAIQSIILAYCYPGDGRLWSVHLPTSIKKIRINPSLCENSAGQEAVLHFKSTITSGRSTEIQGDVELYDTNGVNSIMQLEGLHTKPLGHATPENDRTLFLETIWDTAEPTKELALLAQPDISKKAQLGLDIERVAFYYIRNLGHVTTKADREQAEDYHKHFFNYIDHTVVSVNNGTSLFAKKEWMHDTHEQVLDIIKSYPESIDMKLMYAVGEHLLPVIRHETTMLEYMREDDMLNDFYVKALGFDEYTETMADQVCQLAHRYPHMNVLEIGAGTGGATKRIFKKLGKRFSSYTYTDISTGFFEKAREVFSEVESKMTFKALNIEKDPIAQGYTEGSYDLIVASLVLHATHVMEDTMRNVRRLLKPGGYLIMLELGDYVDMRTGLMFGPLPGWWMGYDDGRKLSPTMSEDDWDKCMKKVGFSGVDAIVPRQEHVPISLAIMTAQAVDEHVEFIRNPFASDGMFLLGHHLTLIGGSTDKTAKLLEAALPYLRSFYKHVTTVKSLASLSTIELPFMGSVICLEDLDVAVFENLSTETLQGVQHLFTKSKSCLWVTQGRKDDNPYQNMTVGLGRVATLEMTHLRLQSLDFDVIDSSTAVIMAKSLLRFEATEAWEQQGLAKNLLWSVEPEMSYEKGSFRVPRLIPNHARNNRYNSSRRLITQNKDPRTSTIGLRWTSKGYEIHNESPASSGLAFDGRVELQVSHSSLEAIRITKADYAYLVLGTNLRTKEQAFAITPDRHSIVRVFDSWTVPYTMTTEEALRLLPLVQDHLMALATMSDFSSGEALILIEPRWRFARLLSNLAQEKGVKLILLTTRLDIKDQDWITLHPNAPRRIIQSHMPKTASRLISCTDDLEFEANVKACLPPNCKMQRTEIFSSRVSKLDSFSSMAFIPSSLRSAFVRAHHESSPGDKESIASVSDIVSRGKPAKATFFSWDSSPTIPVQITPVDLEPLFSSDKTYWLVGLTGGLGLSLCEWMIQRGAKYVVLTSRNPQVDAKWEAHMKAHDAVVRIYANDVTDRDSVRSVYKQIRDELPPIGGVAQGAMVLSDAMFVDMGLERVCKVVEPKVKGAIHLEELFSEADLEFFVFFSSMAYVTGNQGQSIYAAANAYMAALAAQRKKRGLAGSVINIGAIVGNGYVTRQLTDEQRDYLAHMGNVFMSEQDFHQIFAEGVVAGRPGNDDIPEIMTGLGLAHMDDSDKVTWFNNPKFSHCVLWPDDQGAAVGMSKQNVTVKSRLLLATTADEVNEAIQESFTMKLRSSLQIEDSVAILKMNAEELGLDSLVAVDLRSWFVKELNVEMPVLKILGGFTVAELVSAAQEQLPASLTPNFGKEIDPALKAAAMLEKAAKTETVPRITNEANTAAYREEVDEEEQEEDEADNRPNFFSSASKDATQSSERFAIDASHISKSREVAFKATLLAPPATRSKTSSSSSSFTSDPENDFMMKSQMSAATPLSSYNDEYITAEDIKFERVSPMSFGQARFWFLKFYLQDQTTFNITTSIRLSGRLNVETFANAVQAVGRRHEGLRTAFFTDRHNQPMQGILHQSVLHLEHLRVSSQEAIDIEYAKTKNHVYNIGGGETMKIILLSLADDLYQIIIGYHHINMDGMSLEVILSDLQKVYNQQQLARVVPQYLDFSESQRREHSTGKWGKEISFWKGEFADIPAPLPILPMSKKSNRSPLTKYASNTVKFKIDAATSAQIQIACKRAKASPFNFYLAAFKTLLYRTAGEEQNDICIGIADGGRNSEHVEESVGFFLNILPLRFKQDSAQTFLEALRDARSKVVAALANSRVPFDVILNEVNAPRAATHNPLFQAFINYRQGVQERRQFCGCDSEATQFDGSQTAYDISIDILANPGADSTVYISGQSDLYSEENVKLLAHSYLALIKSFAKNPASRLGRPPLYDPQDTHRALDVGVGPELTDTWPNTLVDRVDEMASRFGSQIALKGPRNQLTYSQMTDRIHSIASSLKSNKIGNCSRVGVLQDPSTDFFCSLLAILRIGAIFVPLELRLTSPRLAVIVEDSNIDAIIYDKANQKDLLTLGSGFQKVNVSLIPAKSTSTVVNEAQPGSPAVILYTSGSTGKPKGILLSHASWRNQIQSSTQAFRIPQGTGVHLQQSSWSFDIAISQTFVALANGASLLIVSKELRGDSIAMARMIVSDRITHVQATPSEMVSWLHDADANALRSSSWKFAMSGGEKMNSALIGEFKALGKSDLALVNAYGPAETTLAVGSAEIDILDPGALDTAFRLFPNYSVYILDSKKQPVPLGISGEVYIGGAGVATGYLNNDNLTKERFLPDDFAPERYLQNDWTIMHRSGDRGRLTADGLVLEGRVDGDTQIKLRGIRIDLQDIESTIVQHSKGAVRDAVVSLRKSGETQILAAHIVLSAAFSGNAKTILDSIQTSLPLPQYMRPATTLVVKTLPTNYSGKLDRKAVSELPLRPVSKTSVPVTKENKSPESELRTIWKQVLGDDITSSHEIDYETDFFHVGGNSLALVRVQGMLKAAFNVEPPVAQLFDNSTLGAMLNLISPASQTMSTEHSSLLPNVVEYSPQAAASSGTIDWEKETALTDDLYDAEINPTPRDQGLAFKTVAITGASGFLGKEILKRMVDDVHIDKIHAIAIRRHISDLPAIFSNAKVQVHRGDLNAPRLGLSETRAKEIFDETDTVIHNGADVSFLKTYKTLSKTNVGSTRELVKLCLPSRIPIHFISSASVAHLSGRASFGEESVSEYEPPQDGSDGYTATKWASERFLELVSEKFSIPVWIHRPSSITGAEAPALDLMTNLLQFSKTMSKVPYSPTWSGTLDFVSVESVAHDIVEEVKNDSAHSSGMVRFMYESGDLEIAVQDMQGSLAKQTGEEFDKVDVETWTREAVSEGLDELVAAYLSTAANLPIMFPRLIRDNKRRRIEQKVQEQPSRGSSLREVVGRWLWSRQ
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of the mycotoxins phomacins, leucine-derived cytochalasans with potent actin polymerization-inhibitory activities and monocot-specific antigerminative activities (PubMed:31815421).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS phmA, assisted by the enoyl reductase phmE, that are responsible for fusion of the leucine precursor and the polyketide backbone to produce a 2-pyrrolidone intermediate (PubMed:31815421).  The polyketide synthase module (PKS) of phmA is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the leucine precursor (PubMed:31815421).  Because phmA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase phmE (PubMed:31815421).  Reduction by the hydrolyase phmG, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase phmD then yield the required isoindolone-fused macrocycle (Probable).  A number of oxidative steps catalyzed by the tailoring cytochrome P450 monooxygenase phmB, the FAD-linked oxidoreductase phmC and the short-chain dehydrogenase/reductase phmF, are further required to afford the final products, phomacin D and phomacin E (PubMed:31815421).
What are the official names of this protein?
Polyketide synthase-nonribosomal peptide synthetase phmA, PKS-NRPS phmA, Phomacin biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.