PharMolix/UniProtQA huggingface dataset:
Protein: SETD3_MOUSE
Sequence: MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPSPGKEWEEYTQIRALVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEEEVRCLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKESFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFQAGDQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHSTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNAEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKIVLKNPDLSVRATMAIKLRLGEKEILEKAVKSAAVNREYYRKHMEERAPLPRYEESDLGLLEGGVGDSRLPLVLRKLEEEAGVQESLSLTETVSKVKAAENGLVNGENLIPNGTRSENESLSPEESENVTGEESSGSMAKVKERL
What is the function of this protein?
Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30626964).  Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964).  Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964).
What are the official names of this protein?
Actin-histidine N-methyltransferase, Endothelial differentiation inhibitory protein D10, Protein-L-histidine N-tele-methyltransferase, SET domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
Protein: DAPF_RHIWR
Sequence: MQVRFHKMHGLGNDFVVIDARATAPVEMTAARARALADRKTGVGCDQLILLEPSAVADARMRIFNADGSEVEACGNATRCVVSLLGGSARIETVAGLLEGRSADGQVSVELGEPRFDWDAIPLAYAMDTRAMPVAWEELEAPMAANVGNPHVVFFVPETDAVALDRLGPRIETDPLFPARINVNVATVDDRANIRLRVWERGVGLTDACGTGACATAVSAIRAGLVDSPVRVTLPGGPLTIDWAPGRPIVMTGPATHVFTAETDLSAFGADSRG
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSGA_YERPE
Sequence: MSKNKLSKGQQRRVQANHQRRLRTDRKPELDDSQLGDAQEGIVISRFGQHADVEAVDGTQHRCNIRRTIKSLVTGDRVVWRPGLQAQEGVRVKGIVEAVHERTSVLTRPDLYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLEVEPLIVLNKIDLLDADGRKFVDGMMDIYRRIGYDVLEVSSQTREGMEAFENALTGRISIFAGQSGVGKSSLLNALLPPTDNEILVNTVSGNSGLGQHTTTAARLYHFQHGGDVIDSPGVREFGLWHLAPEQITQGFVEFRDYLGHCKFRDCSHTNDPGCALREAVEQGKIAEERFDNYHRILESMEQAKPRKTSDSDEK
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHON_PROST
Sequence: MKKLLAVFCAGAFVSTSVFAAIPPGNDVTTKPDLYYLKNSQAIDSLALLPPPPEVGSILFLNDQAMYEKGRLLRNTERGEQAAKDADLAAGGVANAFSEAFGYPITEKDAPEIHKLLTNMIEDAGDLATRSAKEKYMRIRPFAFYGVATCNTKDQDKLSKNGSYPSGHTAIGWASALVLSEINPENQDKILKRGYELGQSRVICGYHWQSDVDAARIVASGAVATLHSNPEFQKQLQKAKDEFAKLKK
What are the official names of this protein?
Non-specific acid phosphatase, NSAP.
What is the protein family that this protein belongs to?
Belongs to the class A bacterial acid phosphatase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TT39B_XENLA
Sequence: MAFVSNGTEADEEGFEDAYENIPVASKMDLRCALEECTMALNLFLNNKFSEALELLRPWAKESIYHALGYSTILVMQSAMTFEPQDVQMGITTMKEALQTCQRFRKRNTVVESLSNLVSKQSGDQLTEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGIKIRTSYQIYKECHQMYSLAASQGKMCSDTHYQFEGGVKLGIGAFNLMLSLLPSRVLRLLEFIGFSGNRELGLSQLREGASGSSIRAILCVLTLLFYHTYISLILGTGEANLEEAEALLEPYLKKFPNGSIILFYAARIDILKGRFEQAQETFQKCIVSQQEWKQIHHLCYWELMWCHSFQQDWLQAYRYADLLSKESKWSKATYVFQKAALLSMLPEDVVKTTGEDIVALFRQVESLKQRIAGKSIPTEKFAVRKSRRYISDNPVKLTLPALEMMYVWNGFTIVGKRADLTENVLVTIEKAEVALQNETKVTEYLADDLCLVQLLKGVCLKHLGRLLQAELCFNQVIQSEKRVKYDHYLIPFTFYELGLLYKEQGDRDKAIRYIETAKGNYKDYSLESRLHFRIHAALSSLKGSPVSTPTTPS
What is the function of this protein?
May be involved in lipid metabolism.
What are the official names of this protein?
Tetratricopeptide repeat protein 39B, TPR repeat protein 39B.
What is the protein family that this protein belongs to?
Belongs to the TTC39 family.
Protein: MUTS2_GEOTN
Sequence: MQQKMLRILEFDKVKEQLAEHASSALGLEKIAALVPSSDLDEVAVWLEETDEAAAVLRLRGYVPLDGVVDIRSHLKRAAIGGVLSPIELLEVAATAAASRQMKQLIMSLHDEHGGLARLADYADELAEVPALEEDIRRSIDDHGEVLDTASDRLRSLRGQIRAAEARIREKLESIIRSPSAQKRLSDAIITIRNDRYVIPVKQEYRSAYGGIVHDQSASGATLFIEPQVVVELNNALREARAKEKQEIERILRELSAKVAEHDEPLKRAVEALAHFDFLFAKAKYARRLQAAKPAVNNRGYLRFLQARHPLIDQDKAVPNDIVLGGDYTTIVITGPNTGGKTVTLKTVGLLTIMAQAGLFIPAADGSEAAVFRSVFADIGDEQSIEQSLSTFSSHMVNIVDILRHVDEESLVLFDELGAGTDPQEGAALAIAILDEVHGRGARTVATTHYPELKAYGYNRPGVVNASVEFDTETLRPTYKLLIGIPGRSNAFDISRRLGLDERIIERAKVQVSAESHSVENMIASLERSKKQAEEDEARAHSAREEAERLRAEWEQKLEELEDKKAEQLAEAAQKATDIIRAAEREAERIINELRRLQKEKQAEVKEHELIAAKQRLAAAVPVVEKRKKTKKATARHAFQSGDEVKVTSLNQKGYLLEKVSEDEWQVQLGILKMKIHERDLEYIGSAPAKEVTPIATVKGKDAHVSLELDLRGERYEDALVRLEKYIDDAVLAGYPRVSIIHGKGTGALRQGVQQFLKQHRAVKSFRFGAANEGGTGVTVVELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: TRAM2_MOUSE
Sequence: MAFRRRTKSYPLFSQEFIIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPTADSETVHYHYGPKDLVTILFYVVITIIFHAVVQEYILDKISKRLHLSKVKHSKFNESGQLLVFHLSAVAWCFYVIVTEGYLTNPRSLWEDYPHVYLSFQVKFFYLGQLAYWLHSLPELYFQKVRKEEVPRQLQYICLYLLHITGAYLLNLSRLGLILLLLQYSTEALFHMARLFHFADENNERLFNAWAAVFGVTRLFILTLAVLTIGFGLARVENQVFDPEKGNFNTLPCRLGMLLLVCVAQAWLMWRFIHSQLRHWREYWKEQSAKRRVSAVPRPPAKLLKREPGYHENGVVKAENGTSSRTKKLKSP
What is the function of this protein?
Necessary for collagen type I synthesis.  May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon.  This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.  Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).
What are the official names of this protein?
Translocating chain-associated membrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the TRAM family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNAK_STRS2
Sequence: MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTIISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEEYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLATAGDNKLGGDDFDQKIIDHMVAEFKKENGIDLSADKMALQRLKDAAEKAKKDLSGVTSTQISLPFITAGAAGPLHLEMTLTRAKFDELTYDLVERTKIPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNDVDQAIFATEKTLKETEGKGFDAERDQAQAALDELKAAQEANNLDDMKAKLENLNEKAQALAVKLYEQAAAAQQAAAGQEGAQTANNADDDVVDGEFTEK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: NRDR_RHOPA
Sequence: MRCPNCNSLDTQVKDSRPTEDSSVIRRRRVCIACNFRFTTFERVQLRELIVIKRNGRRVPFDRDKLMRSVQISLRKRPVDPERVEQMVSAIVRELESGGEAEISSETIGESVMDHLRKLDDVAYVRFASVYRNFREAKDFEAVLGELSHEDEARAALVRK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: CAID_SALPB
Sequence: MSESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFFSAGWDLKAAAEGEAPDADFGPGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVMTGRRMSAEEALRWGVVNRVVSQSELMDSARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHSEDALEGPQAFAEKRDPVWKGR
What is the function of this protein?
Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.
What are the official names of this protein?
Carnitinyl-CoA dehydratase, Crotonobetainyl-CoA hydratase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
Protein: YIDC_SALSV
Sequence: MDSQRNLLVIALLFVSFMIWQAWEQDKNPQPQTQQTTQTTTTAAGSAADQGVPASGQGKMITVKTDVLDLTINTRGGDVEQALLPAYPKELGSNEPFQLLETTPQFIYQAQSGLTGRDGPDNPANGPRPLYNVEKEAFVLADGQNELQVPMTYTDAAGNTFTKTFVFKRGDYAVNVNYSVQNTGEKPLEVSTFGQLKQSVNLPPHRDTGSSNFALHTFRGAAYSTPDEKYEKYKFDTIADNENLNVSSKGGWVAMLQQYFATAWIPRNDGTNNFYTANLGNGIVAIGYKAQPVLVQPGQTGAMTSTLWVGPEIQDKMAAVAPHLDLTVDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQPKIQAMRERLGDDKQRQSQEMMALYKAEKVNPLGGCFPLIIQMPIFLALYYMLMGSIELRHAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKKS
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y63_BPT3
Sequence: MDAAKLITVAVLVGMLARGLWMFALIVRDVKRDSEIK
What are the official names of this protein?
Uncharacterized gene 6.3 protein.
Protein: NINJ1_RAT
Sequence: MDPGTEEYELNGDLRPGSPGSPDASPPRWGLRNRPINVNHYANKKSAAESMLDIALLMANASQLKAVVEQGNEFAFFVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPVMDVAPRQ
What is the function of this protein?
Secreted form generated by cleavage, which has chemotactic activity.  Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis.
What are the official names of this protein?
Ninjurin-1, Nerve injury-induced protein 1.
What is the protein family that this protein belongs to?
Belongs to the ninjurin family.
What are the subcellular locations of this protein?
[Ninjurin-1]: Cell membrane; Multi-pass membrane protein. Synaptic cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Secreted ninjurin-1]: Secreted.
Protein: NADK_THEAB
Sequence: MKHLGIFYKPELFGKAESLKELLLNEGYIVDYCESSERIKNNKVDLTIVLGGDGTFLKASHLVNNPLVGFKGGRLGFLSSYTVEEFDKFLKDLKNNNFVSDERTFLKVSDLNTFCLNEVLLVKDPDQKMVDIKISFQDGELFFHADGIMLSTPTGSTGYSLSLGGPILLPNTKAFVITPVAPQFLASRSIVIPDNEKVNIEVDKRVNLIIDGVNFGKFSKITVMKSKKKISILRPVDYDFTKSIKEKLGYGKKIL
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PERF_RAT
Sequence: MAAYLFLLGLFLLLPRPVPAPCYTATRSECKQNHKFVPGVWAAGEGVDVTTLRRSSSFPVNTGKFLRPDRTCTLCKNALMNDGIQRLPVAIAHWRPHGSHCQRNVATTKVSSTEGVAREAAANINNDWRAGLDVNPKPEANVHVSVAGSHSKIANFAAEKAHQDQYNFNTDTVECRMYSFRLAQKPPLHPDFRKALKNLPHNFNSSTEHAYRRLISSYGTHFITAVDLGGRVSVLTALRTCQLTLDGLTADEVGDCLSVEAQVSIGAQASVSSEYKACEEKKKQHKIATSFHQTYRERHVEVLGGPLDSSNDLLFGNQATPEHFSTWIASLPTRPDVVDYSLEPLHILLEDSDPKREALRQAISHYVMSRARWRDCNRPCRAGQHKSSRDSCQCVCQDSNVTNQDCCPRQRGLAKLMVRNFQAKGLWGDYITSTDAYLKVFFGGQEIRTGVVWNNNHPSWSDKMDFGNVLLSTGGPLRVQVWDADNGWDDDLLGTCDKSPKSGFHEVNCPLNHGSIKFIYQANCLPDLTGETCLEYAPQGLLGDPRGNRSGAVW
What is the function of this protein?
Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells (PubMed:2809217).  Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores (By similarity).  Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes (By similarity).  Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu (By similarity).
What are the official names of this protein?
Perforin-1, P1, Cytolysin, Lymphocyte pore-forming protein.
What is the protein family that this protein belongs to?
Belongs to the complement C6/C7/C8/C9 family.
What are the subcellular locations of this protein?
Cytolytic granule. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytolytic granules of cytolytic T-lymphocytes and secreted into the cleft between T- lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (By similarity).
Protein: ERA_ECOK1
Sequence: MSIDKSYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGAYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNKLRDGKAPVILAVNKVDNVQEKADLLPHLQFLASQMNFLDIVPISAETGLNVDTIAAIVRKHLPEATHHFPEDYITDRSQRFMASEIIREKLMRFLGAELPYSVTVEIERFVSNERGGYDINGLILVEREGQKKMVIGNKGAKIKTIGIEARKDMQEMFEAPVHLELWVKVKSGWADDERALRSLGYVDDL
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: MTS17_SELML
Sequence: MAVSSIASIFAAEKSYSIPPVCQLLVSPVLNPLYDAKAESQIDAWCAEFLKLQPGSEKAVFVQESRLGLLAAYVYPTIPYEKIVPVGKFFASFFLADDILDSPEISSSDMRNVATAYKMVLKGRFDEATLPVKNPELLRQMKMLSEVLEELSLHVVDESGRFVDAMTRVLDMFEIESSWLRKQIIPNLDTYLWLREITSGVAPCFALIDGLLQLRLEERGVLDHPLIRKVEEIGTHHIALHNDLMSLRKEWATGNYLNAVPILASNRKCGLNEAIGKVASMLKDLEKDFARTKHEIISSGLAMKQGVMDYVNGIEVWMAGNVEWGWTSARYHGIGWIPPPEKSGTFQL
What is the function of this protein?
Sesquiterpene synthase converting farnesyl diphosphate to eight sesquiterpenes, with (+)-germacrene D and an unidentified oxygenated sesquiterpene as the major products.  Has no diterpene synthase activity.
What are the official names of this protein?
(+)-germacrene D synthase, Microbial Terpene synthase-like protein 17, SmMTPSL17.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: RF1_CAMC5
Sequence: MFADKLRPFLDRYNEISALLGDPNIINDIEKMTKLSKEQSSIEPIKNAASQYLQTLDDIEENKALLDDAELGELAREELKSAQIRKEELENEIKILLLPKDPNDDKNIFLEIRAGTGGDEAALFVGDLFNAYIRYADLRGYKFEIVSQSEGSAGGFKEIILLIKGKGAYSRLKFEGGTHRVQRVPETESQGRVHTSAVTVAIMPEVEDSEIEINPNDLRIDVMRSSGHGGQSVNTTDSAVRITHIPTGLVVTNQDGKSQHKNKEAAMKVLKARLYEMQEAERIAKETSERKSQVGTGDRSGRIRTYNFPQNRISDHRINLTLYRLDAIMAGGLFDEIIEPLIAHHQAEAITDAGL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCB5R_CRYNJ
Sequence: MFTIEVLAQKLAPHASFLGGLVVAAILGLFIFFQEKDRKVLDPVEWRSFKLVDKDHLSHNTALYRFALPRASDSLGLPIGQHISVAAEINGKQVVRSYTPTTLDDDKGHFDLVVKTYEKGNISRYLSLLTIGQEIKVKGPKGKFVYTPNMAPHLVMIAGGTGITPMYQIIKSSIKTPGDKTRLSLIYANIQEDDILLKKEIDELQAKSNGRFDVKYVLNNPPEGWTGGVGFVTKEMIEEAMPSSGVGSANHGEGHKVLMCGPPPMITAMKGHLAQIGYPAPRSVSKLEDQVFLF
What is the function of this protein?
NADH-dependent reductase for DPH3 and cytochrome b5.  Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.  By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex.  The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
What are the official names of this protein?
NADH-cytochrome b5 reductase 1, Microsomal cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: NRDR_ACIBS
Sequence: MHCPFCNAADSKVIDSRLAAEGCQIRRRRECVSCGERFTTFESYEVVMPRVIKSNGKNEPFDEAKLRRSLMHALQKRPVTQEQIETVLSDIQLQIRRLGERDVKSRTIGEIVMQSLFALDHVAYVRFASVYQDFQDVEAFRRQIEQMQQREH
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RS7_GEOSW
Sequence: MPRRGPVPKRDVLPDPIYNSKLVTRLINKIMIDGKKGKAQKILYTAFDIIRERTGKDPMEVFEQALKNVMPVLEVRARRVGGANYQVPVEVRPDRRVTLGLRWLVQYARLRGERTMEERLANEIMDAANNTGAAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RK6_NEOYE
Sequence: MSRIGKKIILLPTNLSTQFDGQTITVTGPKGTLSRTLPAGINLEILNDTIAVKTSGQTKMASQLHGLSRTLISNMIEGVSNGFFKKLQIQGVGYRSQIDNQDLILSVGYSHVVKIKPPANIEIKVENNTNITVSGIDKEVVGQVASTIRSIRPPEPYKGKGIRYQGEFVRRKAGKAGKGK
What is the function of this protein?
Binds 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L6, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ZRAP_ECOLI
Sequence: MKRNTKIALVMMALSAMAMGSTSAFAHGGHGMWQQNAAPLTSEQQTAWQKIHNDFYAQSSALQQQLVTKRYEYNALLAANPPDSSKINAVAKEMENLRQSLDELRVKRDIAMAEAGIPRGAGMGMGYGGCGGGGHMGMGHW
What is the function of this protein?
Binds zinc.  Could be an important component of the zinc-balancing mechanism.
What are the official names of this protein?
Zinc resistance-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ZraP family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RNPH_XANAC
Sequence: MTFSRPSGRTADQLRPVRIERSFTRHAEGSVLVSFGDTRVLCTASVENRVPGFLRGKGEGWVTAEYGMLPRSTHTRSDREAARGKQGGRTLEIQRLIGRALRACVDRNALGERTITLDCDVLQADGGTRTAAITGAYVALADAVNLLIKRGDIKKHPLIGAVAAVSVGIYRGEPVLDLDYPEDSDCDTDMNVVMNDGGGFIELQGTAEGHAFRRDELNALLALAEKGMGELFALQRAALAG
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: NNRD_XANCP
Sequence: MTGPRVRTVTAAALRAQPLPAPGGDKEQRGRVLIVGGSARVPGAVMLAGEAALRAGAGKLQLATAASVAPGMALAMPEALVLGLGENGQGEIVRGHRALDAAMSACDAAVIGPGMASTNTTAALVKRAIDQAVCTLVLDAGALSPRLRAPLGRPFVLTPHAGEMAALAGDDKAAVEAAPADYALAFAKKMRSVVIVKGADSFVAGPDGALWVHRGGVPGLGTSGSGDTLAGLIAGFAARGCDALTAALWGVFVHATAGKQLAKRIGTVGFLAREIPPEVPGILDRLPRG
What is the function of this protein?
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP.  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
What are the official names of this protein?
ADP-dependent (S)-NAD(P)H-hydrate dehydratase, ADP-dependent NAD(P)HX dehydratase.
What is the protein family that this protein belongs to?
Belongs to the NnrD/CARKD family.
Protein: DDB1_SOLCE
Sequence: MSVWNYVVTAHKPTNVTHSCVGNFTGPQELNLIIAKCTRIEIHLLTPQGLQCICLQPMLDVPIYGRIATLELFRPHGETQDLLFIATERYKFCVLQWDTEASEVITRAMGDVSDRIGRPTDNGQIGIIDPDCRLIGLHLYDGLFKVIPFDNKGQLKEAFNIRLEELQVLDIKFLYGCPKPTIVVLYQDNKDARHVKTYEVSLKDKDFIEGPWAQNNLDNGASLLIPVPPPLCGVLIIGEETIVYCSASAFKAIPIRPSITRAYGRVDADGSRYLLGDHNGLLHLLVITHEKEKVTGLKIELLGETSIASTISYLDNAFVFIGSSYGDSQLVKLNLQPDTKGSYVEVLERYVNLGPIVDFCVVDLERQGQGQVVTCSGAYKDGSLRIVRNGIGINEQASVELQGIKGMWSLRSATDDPYDTFLVVSFISETRVLAMNLEDELEETEIEGFNSQVQTLFCHDAVYNQLVQVTSNSVRLVSSTSRDLKNEWFAPVGYSVNVATANATQVLLATGGGHLVYLEIGDGVLNEVKYAKLDYDISCLDINPIGENPNYSNIAAVGMWTDISVRIYSLPDLNLITKEQLGGEIIPRSVLMCSFEGISYLLCALGDGHLLNFVLSMSTGELTDRKKVSLGTQPITLRTFSSKDTTHVFAASDRPTVIYSSNKKLLYSNVNLKEVSHMCPFNVAAFPDSLAIAKEGELTIGTIDEIQKLHIRSIPLGEHARRISHQEQTRTFALCSVKYTQSNADDPEMHFVRLLDDQTFEFISTYPLDQFEYGCSILSCSFSDDSNVYYCIGTAYVMPEENEPTKGRILVFIVEDGKLQLIAEKETKGAVYSLNAFNGKLLAAINQKIQLYKWASREDGGSRELQTECGHHGHILALYVQTRGDFIVVGDLMKSISLLIFKHEEGAIEERARDYNANWMSAVEILDDDIYLGAENNFNLFTVRKNSEGATDEERSRLEVVGEYHLGEFVNRFRHGSLVMRLPDSDVGQIPTVIFGTVNGVIGVIASLPHDQYLFLEKLQTNLRKVIKGVGGLSHEQWRSFYNEKKTVDAKNFLDGDLIESFLDLSRNRMEEISKAMSVPVEELMKRVEELTRLH
What is the function of this protein?
Component of light signal transduction machinery.  Involved in fruit pigmentation and fruit nutritional quality.  Acts as a negative regulator of fruit pigmentation.  Probably acts by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes.  Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5 (By similarity).
What are the official names of this protein?
DNA damage-binding protein 1, UV-damaged DNA-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the DDB1 family.
What are the subcellular locations of this protein?
Nucleus.