PharMolix/UniProtQA huggingface dataset:
Protein: SP100_HYLLA
Sequence: KKCIQSEDKKWFTPREFEIEGDRRASKNWKLSIRCGGYTLKFLMENKLLPEPPSTRKKRILKSHNNTLVDPCAVHKKKNPDASVNLSEFLKKCSEMWKTIFAKEKGKFEDMAKADKAHYEREMKTYIPSKGEKKKKFKDPNAPKRPPLAFFLFCSEYRPKIKGEHPGLSIDDVVKKLAEMWNNTAAADKQFYEKKAAKLKEKYKKDIAADRAKGKPNSAKKRVVKAEKSKKKKEEEEDEVDE
What is the function of this protein?
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis.  Functions as a transcriptional coactivator of ETS1 and ETS2.  Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA.  Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion.  Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening.  May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis.  May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity).
What are the official names of this protein?
Nuclear autoantigen Sp-100, Nuclear dot-associated Sp100 protein, Speckled 100 kDa.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Cytoplasm. Note=Accumulates in the cytoplasm upon FAS activation.
Protein: KGUA_SYNY3
Sequence: MAPDQTSVKGQLIVLTGPSGVGKGTLVQLLLERQPHWFLSISATTRSPRAGEVDGQSYYFLTKEEFQTWIGEEKLLEWAEYAGNYYGTPRQPVEEQIAQGKTVLLEIEVLGARQIKQTFPSARRIFILPPSVEVLEERLRGRGSDSETAIAKRLAQAQQELQAAAEFDYQVVNDDLDQALHRLVKLIGEEE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAT2_GIBZE
Sequence: MAPAASADHDMDVDMIHDEEDDQGERLINEEYKTWKKNSPFLTALTWPTLTVQWFPDVKEPEGKNYKIHRLLLGTHTSDESPNYLQIADVQIPKVVAPNPDDYDEERGEIGGYGKSGDVAAIKCDIVQRIEHPGEVNKARYQPQNPDILATLCVDGKILIFDRTKHPLDPTSTGKVNAQIELVGHEAEGFGLNWNPHEEGCLASGSEDTTMRLWDLKTLKADSRILNPSRTYRHHTQIVNDVQYHPISKNFIGSVSDDQTLQIVDIRHSETNKAAVVAKRGHLDAINALAFNPNSEVLVATASADKTIGIWDLRNVKEKVHTLEGHNDAVTSLAWHPTEAGILGSASYDRRIIFWDLSRVGEEQLPDDQDDGPPELLFMHGGHTNHLADFSWNPNEPWLVASAAEDNLLQIWKVAESIVGKDDGDLPIDELDR
What is the function of this protein?
Regulatory subunit of the histone acetylase B (HAT-B) complex.  The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.
What are the official names of this protein?
Histone acetyltransferase type B subunit 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MAAI2_DROME
Sequence: MSTNLCPNASSSDIQPILYSYWRSSCSWRVRIAMNLKEIPYDIKPISLIKSGGEQHCNEYREVNPMEQVPALQIDGHTLIESVAIMHYLEETRPQRPLLPQDVHKRAKVREIVEIICSGIQPLQNLIVLIHVGEEKKKEWAQHWITRGFRAVEKALSTSAGKYCVGDEISMADCCLVPQVFNARRFHVDLRPYPIILRIDRELESNPAFRAAHPSNQPDCPPELPNK
What is the function of this protein?
Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro.  Has no glutathione thioltransferase activity with 4-hydroxynonenal (4-HNE), adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED).
What are the official names of this protein?
Probable maleylacetoacetate isomerase 2, MAAI 2, Glutathione S-transferase zeta 2.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Zeta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_SHESM
Sequence: MKIVVDENMPYVEPLFGALGEIIPVNGRTLTPEQVQDADVLLVRSVTRVNAALLDANPKLKFVGSATIGTDHVDLAYLARRGIPFSNAPGCNATAVGEFAFIAMLELAARFNSPLKGKVVGIVGAGNTGSATAKCLEAYGIKVLLNDPIKAAEGDPRHFVSLETLLHQADIISLHVPITRSGEHKTLHLFDEARLMSLKPNTWLVNCCRGDVIDNQALIKVKQQRDDLKLVLDVWEGEPHPMPELVPFAEFATPHIAGYSLEGKARGTFMLYQKLCELLAIPANKRLSELLPPFHFKAVELEQTPDEKALLQLARFVYDLRDDDAVFRNGFAKENGFDIMRKNHKHRREFSALALAYHGQSEVDWLSNLGFSGVGR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCB5R_MORAP
Sequence: MTLSNPAIAAASGVILAGAYLIDPSALPFVAAGVAATWARVLFKKTAVKTPPMDPKEYRKFKLVDKVHCSPNTAMYKFALPHEDDLLNLPIGQHISIMANINGKDISRSYTPTSSSDDVGHFVLCIKSYPQGNISKMFSELSIGDSINARGPKGQFSYTPNMCRAIGMIAGGTGLTPMLQIIRAIVKNPEDKTQVNFIFANVTEEDIILKAELDLLSQKHPQFKVYYVLNNAPEGWTGGVGFVNADMIKEHMPAPAADIKVLLCGPPPMVSAMSKITQDLGYDKVNAVSKLPDQVFKF
What is the function of this protein?
NADH-dependent reductase for DPH3 and cytochrome b5.  Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.  By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex.  The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.
What are the official names of this protein?
NADH-cytochrome b5 reductase 1, Microsomal cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: RIR1_BACSU
Sequence: MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQNTVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYNDYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAGRKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVENATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVKTLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKKEKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVSSYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPAVRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAKEKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVAEHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWFFYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTIYYARTKDTGQDSCLSCVV
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
What are the official names of this protein?
Ribonucleoside-diphosphate reductase subunit alpha, Ribonucleotide reductase large subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: DEOB_ECODH
Sequence: MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_WOLTR
Sequence: MNVGRTVKVTQAVVDLKFEGELPRIFNALKSKLEYRGKELILEVSQHIGDNIVRCIAMDSTNGVSRNDEFVDTGAPISVPVGRSTLGRIFNVVGEVIDECGPLKGKYDLESIHRVPPSFTEQKIQEEVLVTGIKVIDLLAPYLKGGKIGLFGGAGVGKTVLIMELINNIAKAHKGFSVFAGVGERTREGNDLYHEMITSNVINVNEHEKSQAVLVYGQMNEPPGARARVALTALTMAEYFRDHENQDVLFFVDNIFRFTQAGSEISALLGRMPSAVGYQPTLATDMGAMQERIASTTSGSITSVQAIYVPADDLTDPAPAATFSHLDSTTVLSRQIAEMGIYPAVDPLDSTSQSLSAEIVGEEHYKVTSEVKRILQTYKSLQDIIAILGMDELSDEDKITVDRARKIQKFFSQPFHVAEVFTGMPGKFVSLSDTVSSFKGIVEGEYDHLPEAAFYMVGNIDEAIKKAELIKDETKVGAKS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PSB_JONDD
Sequence: MTITGSRGFPDGYLAPGSSFLDFAAQHAPTIMPGTQPTFDTIPQDIAPHGTTIVALEYHNGIIIAGDRRATMGTTIAHREIEKVFAADEHSAIAIAGTAGLAIELVRLFQLELEHYEKIEGTPLSLDGKANRLSTMLRSHLHLALQGLPIVPIFAGWDSTRHQGRLFAYDVTGGRYEEPNFTCAGSGSVFARSALKKLWKPQLDATRAITIALEALWDAADDDTATAGPDIIRRIWPIIAVIDHKGFRYVSEADLAHANDTIAHQRSQDHQHVRVLEPGRDGPGNRLPSQGSATIIPESDQS
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PrcB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSPM_PSEAE
Sequence: MKVMTQFHERLRAQAETSQLAIRWRGLPARDRLALLWLGAFLLLVVLYLALWRPAERHLQSARQYFTEQRALHAYIQQQAPNVRQADAAAPQAQIDPAALQGMVTASAAQAGLSVERLDNEGEGAVQVALQPAPFAKLLPWLEQLNGQGVQVAEAGLDRQVDGRVSARLSLRVE
What is the function of this protein?
Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Plays a role in the complex assembly and recruits XcpY resulting in a stable complex in the inner membrane.  Provides thus a link between the energy-providing XcpR protein in the cytoplasm and the rest of the T2SS machinery.
What are the official names of this protein?
Type II secretion system protein M, T2SS protein M, General secretion pathway protein M.
What is the protein family that this protein belongs to?
Belongs to the GSP M family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: Y1318_DEHM1
Sequence: MPSLDVVSVVDMQAMDNAVNNAKRDLGNRYDFKNAKYELVLNRKDKKIEIVAEDEFKLKAIIETLIQQCVRFKLDSKCLDVADAHTVSLGAAKTEIKIKDGLTKETASKITKFIKSTKLKLDSAIQGEQIRITGKQIDDLQEIMQLLNGQDFDVPLQYVNMKR
What are the official names of this protein?
UPF0234 protein DET1318.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: NUON_SHIB3
Sequence: MTITPQNLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLANANHLASLFLGIELISLPLFGLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGDLSFVALGKNLGDGMLNEPLLLAGFGMMIVGLGFKLSLVPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQTGEMSMEAVGGYLAGYLFSSLGAFGVVSLMSSPYRGPDADSLFSYRGLFWHRPILAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAIGLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLISALLVLVLGVWPQPLISIVRLAMPLM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MATK_ENSLA
Sequence: MEELQGYLEKDRSRQQYFLYPLLFQEYIYVFAYDHGLNSSIFYEPANFGGYDNKSSSVLVKRLIIRMYQQNYFIYSVNDSYQNRFVGHNNYFYSHFFSQMISEGFAVIVEIPFSLQLVSSLEEKKIPKSHNLQSIHSIFPFLXDKFSHLNYLSDILIPHPIHMEILVQILQSWIQDVPSLHLLRFFLYEYYNWNSLITPKKSIYVFSKENKRLFWFLYNSYVSECEFLLVFLRKQSSYLRLTSFGAFLERTHFYGKIEHLVVCRNFFQNTLWVFKDPFMHYVRYQGKAILGSRGTHFQMKKWKCHFVNFWQYYYHFWSQPCRIHINQLSNYSFYFRGYLSSVLINSSAVRNQMLENSFIMDIFTKKFDTIVPIIPLVRSSSKAKFCTVSGHPISKSIWTDLSDCDIINRFGRICRNLSHYHSGSSKKQSLHRMKYILRLSCARTLARKHKSTVRSFLQRLSSGLLEEFFTEEEQVLSLIFPKITSFYLHGSYRERIWYLDIIRINDLVNNL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: END8_SALDC
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFAQLKPYESQLTGQLVTRIETRGKALLTHFSNGLTLYSHNQLYGVWRVIDTGEIPQTTRILRVRLQTADKTILLYSASDIEMLTAEQLTTHPFLQRVGPDVLDARLTPEEVKVRLLSPRFRNRQFSGLLLDQAFLAGLGNYLRVEILWQVGLTGQHKAKDLNEAQLNALSHALLDIPRLSYTTRGQSDENKHHGALFRFKVFHRDGEACERCGGIIEKTTLSSRPFYWCPHCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: MANF_ASPFC
Sequence: MHPLPSVALLSAIGAVAAQVGPWGQCGGRSYTGETSCVSGWSCVLFNEWYSQCQPATTTSTSSVSATAAPSSTSSSKESVPSATTSKKPVPTGSSSFVKADGLKFNIDGETKYFAGTNAYWLPFLTNDADVDSVMDNLQKAGLKILRTWGFNDVNSKPSSGTVYFQLHDPSTGTTTINTGADGLQRLDYVVSAAEKRGIKLLIPLVNNWDDYGGMNAYVKAYGGSKTEWYTNSKIQSVYQAYIKAVVSRYRDSPAIMAWELSNEARCQGCSTDVIYNWTAKTSAYIKSLDPNHMVATGDEGMGVTVDSDGSYPYSTYEGSDFAKNLAAPDIDFGVFHLYTEDWGIKDNSWGNGWVTSHAKVCKAAGKPCLFEEYGLKDDHCSASLTWQKTSVSSGMAADLFWQYGQTLSTGPSPNDHFTIYYGTSDWQCGVADHLSTL
What is the function of this protein?
Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.
What are the official names of this protein?
Probable mannan endo-1,4-beta-mannosidase F, Endo-beta-1,4-mannanase F.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: UQCC1_MOUSE
Sequence: MALLVRVLRNQTSISQWVPVCSQLVSVSPTQRQWSSTSQWLQKNQSRVCLGSEQTVGADTAQNRKYHNTSKLLTTQDFPQPVEEKVGPFTKIIEAMGFTGPLKYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRTGKYMCRIIVHFMWEDVEQRGRVMGVNSYILKKNMALMTNNFYAAILGYDEGILSDDHGLAAALWRTFFNQKCEDPRQLELLVEYVRKQMQYLDSMNGEDLLLTGEVRWRPLVEKNPQSILKPHAPTYNDEGL
What is the function of this protein?
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex) (PubMed:35977508).  Involved in cytochrome b translation and/or stability (PubMed:35977508).
What are the official names of this protein?
Ubiquinol-cytochrome-c reductase complex assembly factor 1, Basic FGF-repressed Zic-binding protein, mbFZb, Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog.
What is the protein family that this protein belongs to?
Belongs to the CBP3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Cytoplasmic vesicle. Note=Cytoplasmic vesicular structures.
Protein: FAS2_CANAX
Sequence: MKPEIEQELSHTLLTELLAYQFASPVRWIETQDVFLKQHNTERIIEIGPSPTLAGMANRTIKAKYESYDAALSLQRQVLCYSKDAKEIYYKPDPADLAPKETPKQEESTPSAPAAATPTPAAAAAPTPAPAPASAGPVESIPDEPVKANLLIHVLVAQKLKKPLDAVPMTKAIKDLVNGKSTVQNEILGDLGKEFGSTPEKPEDTPLEELAEQFQDSFSGQLGKTSTSLIGRLMSSKMPGGFSITTARKYLESRFGLGAGRQDSVLLMALTNEPANRLGSEADAKTFFDGIAQKYASSAGISLSSGAGSGAGAANSGGAVVDSAALDALTAENKKLAKQQLEVLARYLQSRLKQGSLKSFIKEKEASAVLQKELDLWEAEHGEFYAKGIQPTFSALKSRTYDSYWNWARQDVLSMYFDIIFGKLTSVDRETINQCIQIMNRANPTLIKFMQYHIDHCPEYKGETYKLAKRLGQQLIDNCKQVLTEDPVYKDVSRITGPKTKVSAKGNIEYEETQKDSVRKFEQYVYEMAQGGAMTKVSQPTIQEDLARVYKAISKQASKDSKLELQRVYEDLLKVVESSKEIETEQLTKDILQAATVPTTPTEEVDDPCTPSSDDEIASLPDKTSIIQPVSSTIPSQTIPFLHIQKKTKDGWEYNKKLSSLYLDGLESAAINGLTFKDKYVLVTGAGAGSIGAEILQGLISGGAKVIVTTSRFSKKVTEYYQNMYARYGAAGSTLIVVPFNQGSKQDVDALVQYIYDEPKKGGLGWDLDAIIPFAAIPENGNGLDNIDSKSEFAHRIMLTNLLRLLGAVKSKKPTDTRPAQCILPLSPNHGTFGFDGLYSESKISLETLFNRWYSEDWGSKLTVCGAVIGWTRGTGLMSANNIIAEGIEKLGVRTFSQKEMAFNILGLLTPEIVQLCQEEPVMADLNGGLQFIDNLKDFTSKLRTDLLETADIRRAVSIESAIEQKVVNGDNVDANYSKVMVEPRANMKFDFPTLKSYDEIKQIAPELEGMLDLENVVVVTGFAEVGPWGNSRTRWEMEAYGEFSLEGAIEMAWIMGFIKYHNGNLQGKPYSGWVDAKTQTPIDEKDIKSKYEEEILEHSGIRLIEPELFNGYDPKKKQMIQEIVVQHDLEPFECSKETAEQYKHEHGEKCEIFEIEESGEYTVRILKGATLYVPKALRFDRLVAGQIPTGWDARTYGIPEDTISQVDPITLYVLVATVEALLSAGITDPYEFYKYVHVSEVGNCSGSGMGGVSALRGMFKDRYADKPVQNDILQESFINTMSAWVNMLLLSSSGPIKTPVGACATAVESVDIGIETILSGKAKVVLVGGYDDFQEEGSYEFANMNATSNSIEEFKHGRTPKEMSRPTTTTRNGFMEAQGSGIQVIMTADLALKMGVPIHAVLAMTATATDKIGRSVPAPGKGILTTAREHHGNLKYPSPLLNIKYRKRQLNKRLEQIKSWEETELSYLQEEAELAKEEFGDEFSMHEFLKERTEEVYRESKRQVSDAKKQWGNSFYKSDPRIAPLRGALAAFNLTIDDIGVASFHGTSTVANDKNESATINNMMKHLGRSEGNPVFGVFQKYLTGHPKGAAGAWMLNGAIQILESGLVPGNRNADNVDKLLEQYEYVLYPSRSIQTDGIKAVSVTSFGFGQKGAQAVVVHPDYLFAVLDRSTYEEYATKVSARNKKTYRYMHNAITRNTMFVAKDKAPYSDELEQPVYLDPLARVEENKKKLVFSDKTIQSNQSYVGEVAQKTAKALSTLNKSSKGVGVDVELLSAINIDNETFIERNFTGNEVEYCLNTAHPQASFTGTWSAKEAVFKALGVESKGAGASLIDIEITRDVNGAPKVILHGEAKKAAAKAGVKNVNISISHDDFQATAVALSEF
What is the function of this protein?
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH.  The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase.
What are the official names of this protein?
Fatty acid synthase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.
Protein: YBEY_BACAH
Sequence: MSLLIDFIDETEEVKEEYVNLIREILGKAAQMEKIEDGAELSVTFVDNERIREINRDYRDKDQPTDVISFAMEEMGEGEMEIVGVEMPRMLGDLIISIPRAKEQAEEYGHSFDRELGFLALHGFLHLLGYDHMTEEDEKEMFGRQKEILEAFGLGR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCNH1_RAT
Sequence: MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAASTSTVSDHAKLHAPGSECLGPKAGGGDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVKHELKEDIKALNAKMTSIEKQLSEILRILMSRGSSQSPQDTCEVSRPQSPESDRDIFGAS
What is the function of this protein?
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:7925287, PubMed:9400421, PubMed:24495567, PubMed:27516594).  Channel properties are modulated by subunit assembly.  Mediates IK(NI) current in myoblasts.  Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity).
What are the official names of this protein?
Potassium voltage-gated channel subfamily H member 1, Ether-a-go-go potassium channel 1, EAG channel 1, EAG1, r-eag, Voltage-gated potassium channel subunit Kv10.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Presynaptic cell membrane. Perikaryon. Postsynaptic density membrane. Early endosome membrane. Note=Perinuclear KCNH1 is located to NPC-free islands.
Protein: TM213_MOUSE
Sequence: MAQSGVFLRNPGHLTSAPQAALLFSLVLTSFHLSCGTETSSSNSTLSAHHPDPGTLEQCANVDFCPLASLCCRASVDEYGWIAAAVGWSFWFLTLILLCVDKLMKLTPEEPKDLAA
What are the official names of this protein?
Transmembrane protein 213.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: YRAK_BACSU
Sequence: MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVANHLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGAVIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRLETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSASRELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC
What are the official names of this protein?
Uncharacterized hydrolase YraK.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: PUR5_METS3
Sequence: MVTYSESGVDIDLEAVTVSKLASKLKSTLEYRDIITDSGHYAALVRLGDKAIAMSTDGVGSKILIAEMMNKYDTVGIDCIAMVVNDILCVGAEPIALVDYLAVEQPDPERAEEIAEGLVTGAKESRISIIGGETASLPGIIKDFDLAGTGIGFVDVDKIITGEDIEAGDVLIGIESNGIHSNGYSLARKALFDDAGFSIDDKMPNCDTTIGEELIRPTELYVKPIVALFKEEYDIHGLAHITGGGFTNLRRLKKGVGYDIYDLPEAPEIFKLIYQQNVPLEEMYKVFNMGIGFVVITNENEAEKIMETLKDYCNCQIIGKVTDDEKITVKTFEGSEVTY
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_XANCP
Sequence: MSTVEPNAYDPQQVETSAQQFWDATRAFQVDENSDKPKFYCLSMLPYPSGALHMGHVRNYTISDVVSRYKRMTGHNVLQPMGWDAFGLPAENAAIKNKTAPAKWTYANIEHMRAQLKSLGYAIDWSREFATCTPDYYVHEQRMFTRLMRKGLAYRRNAVVNWDPIDQTVLANEQVIDGRGWRSGALVEKREIPQWFLRITDYAQELLDGLDQLDGWPDSVKTMQRNWIGRSEGLEIQFDVRDTTGAALDPLRVFTTRPDTLMGVTFVSIAAEHPLAQHAAKSNPELASMLETLKHGGVSEAELETQEKRGMATGLTAVHPISGEEVPVWVANFVLMGYGTGAVMAVPGHDQRDFEFANKYGLPIVQVVKLREPRNDDEQAWDATQWRDWYTDKSRELELINSAEFDGLDYHGAFEALAERFERKGQGQRRINYRLRDWGVSRQRYWGCPIPVIYCAKCGAVPVPEDQLPVVLPENVEFAGTGSPIKTDPTWRQTTCPECGGPAERETDTFDTFMESSWYVARYTSPNARDMVDRRANYWMPADLYVGGIEHAILHLMYFRFYHKLMRDARLVDSDEPVTNLLTQGMVIAETFYRDADNGGKDWINPADVEIQRDERGRVVGASLIADGQPVHIGGTEKMSKSKNNGVDPQAMVAKYGADTVRLFSMFAAPPEQSLEWNEAGVDGMARFMRRLWVQVHKHVGEGAAALDVASLSAEQKAIRRKTHETIGKVDDDYGRRHSFNTAIAAVMELSNALAKFDDASAQGRAVRQEALEAMVLLLNPITPHASHALWQVLGRGETLLENVPFPQVDAAGAGA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.