PharMolix/UniProtQA huggingface dataset:
Protein: FIB_STAAC
Sequence: MKNKLIAKSLLTLAAIGITTTTIASTADASEGYGPREKKPVSINHNIVEYNDGTFKYQSRPKFNSTPKYIKFKHDYNILEFNDGTFEYGARPQFNKPAAKTDATIKKEQKLIQAQNLVREFEKTHTVSAHRKAQKAVNLVSFEYKVKKMVLQERIDNVLKQGLVK
What is the function of this protein?
Extracellular fibrinogen-binding protein that plays an important role in virulence.  By interacting with the alpha chain of fibrinogen and its derivative fibrin, enhances a non-functional interaction between fibrinogen and platelets and is responsible for repression of fibrinogen-dependent platelet aggregation.  In addition, assembles a fibrinogen protective shield around the bacteria which results in impaired phagocytic clearance by the host.  Mechanistically, interacts with host complement C3b deposited on the surface of the bacterium via its C-terminal and then recruits fibrinogen via its N-terminal.
What are the official names of this protein?
Fibrinogen-binding protein.
What are the subcellular locations of this protein?
Secreted.
Protein: H16A1_CYRHA
Sequence: MNTVRVTFLLVFVLAVSLGQADKDENRMEMQEKTEQGKSYLDFAENLLLQKLEELEAKLLEEDSEESRNSRQKRCIGEGVPCDENDPRCCSGLVCLKPTLHGIWYKSYYCYKK
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U11-theraphotoxin-Hhn1a, U11-TRTX-Hhn1a, Hainantoxin-XVI, HNTX-XVI, Peptide F4-19.87.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 14 (magi-1) family. 01 (HNTX-16) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LSPA_BURO1
Sequence: MAKTLSKPASGALAPWLGISLIVILFDQLSKIAILKTFAYGAQHALTSFFNLVLVYNRGAAFGFLSTASGWQRWAFTALGVGATLVICFLLKRHGHQRLFSVSLALILGGALGNVIDRLVYGHVIDFLDFHLGAWHFPAFNLADSAITVGAVLLIYDELRRVRGAR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
Protein: EMAL4_HUMAN
Sequence: MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDPSPSS
What is the function of this protein?
Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757).  Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526).  Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526).
What are the official names of this protein?
Echinoderm microtubule-associated protein-like 4, EMAP-4, Restrictedly overexpressed proliferation-associated protein, Ropp 120.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EMAP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center. Midbody. Note=Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis.
Protein: DAPA_RICRO
Sequence: MHNIFKGLITALITPFKDNKLDLYALERIVKHQIKHEVDAILIAGSTGESSSLSFEEYKLLLQTSVEIVNKCIPIISGCSSNNTTYARALAAESTKIGVDGFMASPPSYVKPTQHGIYKHFEALHEACNLPIMLYSAPTRSGVDFSDETILRLSKLPRILALKDCGVDLERPLRIRATVKKDFNILTGNDEVVLAFNAQGGVGWTSVASNIVPNICKELLEKWNKNDTKGALEIHQKLLPLYTALFVESNPIPIKYAAHYLGLCENEIRPPLTEASDSAKKQIENIITSLSIKI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y513_ARCFU
Sequence: MDKVSYIGPVILDEPEEFSLSEFARQVVAMEAERLYYSNGRIFFIEYDTIHGILDDRLVIVELITYTSFTTVGEYRNWIVYYGNDDTAEYVEKIKDLRGDMTIIPVLRTHDRFIRKIEEQISKGQFRSFASQ
What are the official names of this protein?
Uncharacterized protein AF_0513.
Protein: PHNK_ECOLI
Sequence: MNQPLLSVNNLTHLYAPGKGFSDVSFDLWPGEVLGIVGESGSGKTTLLKSISARLTPQQGEIHYENRSLYAMSEADRRRLLRTEWGVVHQHPLDGLRRQVSAGGNIGERLMATGARHYGDIRATAQKWLEEVEIPANRIDDLPTTFSGGMQQRLQIARNLVTHPKLVFMDEPTGGLDVSVQARLLDLLRGLVVELNLAVVIVTHDLGVARLLADRLLVMKQGQVVESGLTDRVLDDPHHPYTQLLVSSVLQN
What is the function of this protein?
Belongs to an operon involved in alkylphosphonate uptake and C-P lyase.  Exact function not known.  PhnK is not required for the ribophosphonate triphosphate (RPnTP) synthase reaction.
What are the official names of this protein?
Putative phosphonates utilization ATP-binding protein PhnK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: AN32B_XENLA
Sequence: MDMKKRLMLELRNRKAADAKELVLDNCRSDDGKIIGLTSEFESLEFLSMINVNLLSVANLPKLPKLKKLELSDNRISGGLEVLAERTPNLTHLNLSGNKIKEINTLEPLKKLPHLMSLDLFNCEVTMLNNYRESVFELLPKLTFLDGFDADDQEAPDSDPEAEDLEENGEDGEEDEEDDEEEEEFEDELDDEDEDEEGEEEEDGEEEDEDDEDVPQGEKRKRDLSDEGEEEEEDDEDDE
What is the function of this protein?
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor.  Required for the progression from the G1 to the S phase.  Anti-apoptotic protein which functions as a caspase-3 inhibitor.  Has no phosphatase 2A (PP2A) inhibitor activity.  Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity).
What are the official names of this protein?
Acidic leucine-rich nuclear phosphoprotein 32 family member B.
What is the protein family that this protein belongs to?
Belongs to the ANP32 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOLD_STRE4
Sequence: MVQIIDGKALAQKMQAALAKKVESLKAEKGIVPGLVVILVGDNPASQVYVRNKERAALAAGFKSETVRLSDSVCQEELIELIEQYNQDDTIHGILVQLPLPHHINDKSIILAIDPKKDVDGFHPMNTGHLWSGRPNMVPCTPAGIMEMFHDYGIELEGKNAVIVGRSNIVGKPMAQLLLDKNATVTLTHSRTRRLADICRRADILIVAIGQGHFITKEFVKEGAVVIDVGMNRDVNGRLIGDVAFDEVSELASMITPVPGGVGPMTITMLLEQTYQAALRRVSQ
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: DNAJ_SALAR
Sequence: MAKRDYYEVLGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKAAYEVLTDAQKRAAYDQYGHAAFEQGGMGGGFNGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMDLTLEEAVRGVTKEIRIPTLEECDVCHGSGAKAGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCHKCHGHGRVEKSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPSETQTGKLFRMRGKGVKSVRGGSQGDLLCRVVVETPVGLSEKQKQLLKDLQESFGGPTGEKNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOEB_STRCO
Sequence: MRITFTSHGWEDYVHWAESDRKVTKRINRLIADIARDPFKGVGKPEPLKGDLSGYWSRRIDDTHRLVYKPTDDQLVIVQARYHY
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity).
What are the official names of this protein?
Toxin YoeB, Endoribonuclease YoeB, Putative mRNA interferase YoeB.
What is the protein family that this protein belongs to?
Belongs to the YoeB family.
Protein: BDS3D_BUNGR
Sequence: MSYERLLCLVLVASFIAASVAQHPGDAPRMEDDSSAIQRRGLPCGCRGKSGIYWFSGKCPGGYGYTTYCSYVIGLCCVK
What is the function of this protein?
Potently and selectively inhibits voltage-gated potassium channels Kv11/KCNH/ERG.  Acts as a gating-modifier toxin that shifts the voltage-dependence of ERG activation in the positive direction and suppresses its current amplitudes elicited by strong depolarizing pulses that maximally activate the channels.
What are the official names of this protein?
U-actitoxin-Bgr3d, U-AITX-Bgr3d, U-AITX-Bg1e.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RL19_PASMU
Sequence: MSNIIKQLEQEQLKQNLPSFRPGDTLEVKVWVVEGSKRRLQAFEGVVIAIRNRGLHSAFTLRKVSNGVGVERVFQTHSPIVDSITVKRKGAVRQAKLYYLRERSGKSARIKERLGD
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: TDH_SHEPC
Sequence: MKALSKLKAEKGIWLVDAPKPEMGHNDLLIKIKKTAICGTDMHIYNWDEWSQKTIPVPMVVGHEYVGEVVDIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTSGVGVNREGSFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVSKENLKDVMKELGMTEGFDVGLEMSGVPSAFHAMLDTMNHGGKVAMLGIPGGEMAIDWSKVIFKGLVIKGIYGREMFETWYKMASLIQSGLDISPIITHHYKIDDFQKGFDAMGSGQSGKVILSWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFD_KLEP3
Sequence: MVFRIASSPYTHNQRQTSRIMLLVLLAAVPGIVVQTWFFGWGTVLQIVLAALTAWATEAAILKLRKQHIVATLKDNSALLTGLLLAVSIPPLAPWWMVVLGTAFAVVIAKQLYGGLGHNPFNPAMIGYVVLLISFPVQMTSWLPSYEIAAQVPAFSDVLQMIFTGHTAAGGDMASLRLGIDGISQATPLDTFKTSLHAGHSVQQVLQLPVYGGVLAGLGWQWVNIAWLAGGLFLLWQKAIRWHIPVSFLLSLGLCATLGWLFSPHSLASPQMHLFSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWLIRSFGGYPDGVAFAVLLANITVPLIDYYTRPRVYGHR
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAIE_PROSL
Sequence: MSIYAFEGVIPVVHPTAYIHPSAVLIGDVIIGAGVYIGPLASLRGDYGRLIVEAGANLQDGCVMHGYTDMDTIVQENGHIGHGAILHSCIIGRDSLVGMNSVIMDGAIIGEESIVAAMSFVKAGFQGQARQMLMGSPAKHVRDISDQDMQWKRMNTREYQDLTVRCRQGLVETTPLTAPEANRPRLRGTTEVKPKGQ
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: NTPPA_ACHLI
Sequence: MLILGSGSARRKELLESASIDFLLVPSDYNESQVAFEGDTLKYVETIAENKAKALLHKYPLDVILTADTVVEVDGEILGKPKDIEDAQKMLQLLNDKTHHVYTGVCIVSKDKKEVFVESASVTFNKLSTLDIESYIQTKEPMDKAGAYAIQGIGAKLIKQYDGDFHTIMGLPLKLVLEKLKDFNIVPKLK
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORF4_PCV2
Sequence: MTCTLVFQSRFCIFPLTFKSSASPRKFLTNVTGCCSATVTRLPLSNKVLTAVDRSLRCP
What is the function of this protein?
Antagonizes host cell apoptosis by interacting with host ferritin heavy chain.  The ORF4 protein physically binds host FHC, resulting in the reduction of FHC protein levels in host cells.  Reduction of FHC concentration further inhibits the accumulation of reactive oxygen in host cells, leading to reduced apoptosis.
What are the official names of this protein?
Anti-apoptotic ORF4 protein.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: ILVC_CHLAD
Sequence: MAELYYDNQADLNRLKHKPIAIIGFGSQGHAHARNLADSGLDVRVGLYPGSKSWAKVEEAGLKVMTVAEAAREAQIVMILTPDIGQAELYREHIAPAMEPGKTLMFAHGFNIRFGQIVPPAGIDVSMVAPKAPGHRVREVFVQGGGVPALIAVEQDATGGAFEDALAYAKGLGCTRAGVLRTTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFYQGGLNYMRYSVSDTAEWGDYTAGPKIITEQTRAAMRQILADIQSGAFAEDWIEENHNGRPRFNAYRQADINHPIEQIGRELRRMMPFVNPREVKPGEGGA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SYT_PSEE4
Sequence: MPVITLPDGSQRTFDQPVSVAEVAASIGAGLAKATLAGKVDGKLVDACDKIDHDATLQIITPKDEEGLEIIRHSCAHLIGHAVKQLYPTAKMVIGPVIDEGFYYDIAYERPFTPDDLAAIEKRMQQLIDTDYDVVKKMTPRAEVIDVFTSRGEDYKLRLVEDMPDEQAMGLYYHEEYVDMCRGPHVPNTRFLKAFKLTKLSGAYWRGDAKNEQLQRVYGTAWADKKQLAAYIQRIEEAEKRDHRKIGKQLDLFHLQEEAPGMVFWHANGWTVYQVLEQYMRQVQRENGYQEIKTPQVVDRILWERSGHWSNYAENMFTTSSENRDYAVKPMNCPCHVQVFNQGLKSYRDLPLRLAEFGACHRNEPSGALHGIMRVRGFVQDDAHIFCTEDQVKKEAADFIKLTLDVYKDFGFTDVAMKLSTRPAKRVGSEELWDRAEGALADALNESGLEWEYQPGEGAFYGPKIEFTLRDCLGRNWQCGTLQYDPNLPERLDASYIAEDNSRVRPVMLHRAILGSFERFIGMLIEHYAGVFPAWLAPTQAVIMNITDKQADFALEVEKALNGSGFRAKSDLRNEKIGFKIREHTLLRVPYLLVIGDREVETQTVAVRTREGADLGSMPVAQFAELLSQAVSRRGRQESE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_STAAS
Sequence: MPRKGSVPKRDVLPDPIHNSKLVTKLINKIMLDGKRGTAQRILYSAFDLVEQRSGRDALEVFEEAINNIMPVLEVKARRVGGSNYQVPVEVRPERRTTLGLRWLVNYARLRGEKTMEDRLANEILDAANNTGGAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: COPZA_DICDI
Sequence: MSSFLYTVTSFFILDSSKGERVIAKYYNNDFDTLQKQKAFEKKVFDKTSKVNFGGEITLLDNYLVVYKSFSNIIIYMVGDQNQNEIALLYVLNSFIDTLQNLFENSQINKKLILDGINYTLLTLDEIIDGGIIMESDSAVIADRVGIKAPDNDDLDESINKAVTSVKEQLFNFLK
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).  The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
What are the official names of this protein?
Probable coatomer subunit zeta-A, Zeta-A-coat protein, Zeta-A COP.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DPO3B_STAAR
Sequence: MMEFTIKRDYFITQLNDTLKAISPRTTLPILTGIKIDAKEHEVILTGSDSEISIEITIPKTVDGEDIVNISETGSVVLPGRFFVDIIKKLPGKDVKLSTNEQFQTLITSGHSEFNLSGLDPDQYPLLPQVSRDDAIQLSVKVLKNVIAQTNFAVSTSETRPVLTGVNWLIQENELICTATDSHRLAVRKLQLEDVSENKNVIIPGKALAELNKIMSDNEEDIDIFFASNQVLFKVGNVNFISRLLEGHYPDTTRLFPENYEIKLSIDNGEFYHAIDRASLLAREGGNNVIKLSTGDDVVELSSTSPEIGTVKEEVDANDVEGGSLKISFNSKYMMDALKAIDNDEVEVEFFGTMKPFILKPKGDDSVTQLILPIRTY
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_CAMFF
Sequence: MIVEALNNPFDAEFNKVSSDKSISHRCAIFSLLSDKVSKISNYLEAEDTMNSLKIIEKLGAKVEFKNGVYLITPPKKIVSPNAILECGNSGTAMRIFMGLLAGCDGFFVLSGDKYLNERPMKRVASPLMQIGAKIDGRDCANKAPLAIRGGELNYFAYNSSVASAQVKTALILAGLCSAGCKFKEPELSRDHSERMLLGMGAQISQSGLEIEVKPLKGAYLKPLILDVPNDPSSCFFYAVAAAIIPGSKIIIKNILLNKTRIEAYKVLEKMGAKITYTKTSSTYEDIGDICVQYSELKSVDVNQNISWLIDEAPALAIAFACANGVSTLKNAKELRVKECDRIAITVAALKKCGIEAVELEDGFSIKGGKPNSATIDSHGDHRIAMSFAILGLKCGMNIEKSEFIATSFPKFSYFLRELGARVED
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBMX_MACFA
Sequence: MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGMGGRAPVSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSGRDRVGRQDRGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGGRSRY
What is the function of this protein?
RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes.  Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs.  Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression.  When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter.  Associates with nascent mRNAs transcribed by RNA polymerase II.  Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection.  Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN.  Represses the splicing of MAPT/Tau exon 10.  Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer.  Binds non-specifically to pre-mRNAs.  Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity).
What are the official names of this protein?
RNA-binding motif protein, X chromosome, Heterogeneous nuclear ribonucleoprotein G, hnRNP G.
What are the subcellular locations of this protein?
Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus (By similarity).
Protein: LPXK_PHEZH
Sequence: MKLATPRWWYERDRRSMPMTRALLTPLSWAWAGVTARRIARARPLDAGAPVICVGNLTMGGAGKTPVVREIARRLGGHVLSRGYGGSLAGPVRVDPAVHASGEVGDEPLMLARDLPVWVSRDRLAGARAAAAAGARVVVMDDGHQNPSVKKALSLVVVDGETRNGEWPFGDGRVFPAGPMREPLAAGLARADAAVILLPADLAAPDPELVRVLSKVPVLIARLEPEGPPPVGPQVAFAGIGKPWKFERALKAAGCELVEFAPFPDHYAYDAAALALLADRAAQDGAGLLTTEKDWIRLPPAWRERVRPWPVRAVFQDEAALDAVVGGL
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.