PharMolix/UniProtQA huggingface dataset:
Protein: PUR9_RHIE6
Sequence: MAVISKKIPAPDKVEIKTALLSVFDKTGIVELAQALSERGVRLLSTGGTYKAIATAGLAVTDVSDITGFPEIMDGRVKTLHPTVHGGLLAIRDDSEHQEAMKKHGIEGIDLAVINLYPFEEVRAAGGDYPTTVENIDIGGPAMIRASAKNHAYVTILTDPNDYAEFKEQLSADAGKTAYAFRQRMAAKAYARTAAYDAAISNWFAEALSIDAPRHRVIGGVLKEEMRYGENPHQKAAFYVTGEKRPGVSTAVLLQGKQLSYNNINDTDAAYELVAEFLPEKAPACAIIKHANPCGVATGSSLVEAYRRALACDSVSAFGGIIALNQILDAETAEEIVKLFTEVIIAPDVTEEAKAIVVRKPNLRLLSAGGLPDPRVAGLTAKTVSGGLLVQSRDNGMVEDLELKVVTKRAPTSQELEDMKFAFKVGKHVKSNAVVYAKDGQTAGIGAGQMSRVDSARIAALKAEEAAKALGLAVPMTKGSAVASEAFLPFADGLLSMIAAGATAVIQPGGSMRDQEVIDAANEHGIAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: EX7L_CLOD6
Sequence: MKLRALDISEANSYIKRILINDPILSNLKVKGEISNFKVHSSGNVYLSLKDETSKLNCVIFKSNFNRNLKLDNGVKIIANGYISVYERDGAYQLYINEIEIEGIGNLHIEFNRLKEKLNKEGLFDPKYKIPIPKMPNSIGVITSPTGAVIRDIINVIKRRYPKVNIKLYPVTVQGDKSAEEICEAIRFFNHMKNVDTLIVGRGGGSIEELWSFNDEMVAREVFNSQIPIISAVGHETDFTICDFVSDMRAPTPSAAAEIATPSLDDINYKLGNIKSRMSKSLTNQIELDQYRLETVFNKINNYLDSYTIKDKVIQLDKIYDKIIFGIENNLKLEDEKLVKIGALLHNLSPLATMDRGYSITQKNGKVINSIKGLKIKDSIDIVLKDGNLECMIDKIENKEG
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_PYRNV
Sequence: MSAVINKEALLAKIEEALRRGKPRRFRQSVELILVLREVDLSKPENRINLLVELPHPPKPNKVAAFAHGAFEVQAKNAGVDAVISRDQVEGLSGNKRAIRKLAKQYDFFIAPPDLMPLLGRVVGPIFGPRGKMPEVAPPNVDVKSLVERLRRSVRVKLRNEPVIKVRIGAEGQKPEEVLENALAVLEDVNRKFSLRQYLKDVYIKKTMGPPVKAKALEVLAR
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: YUZN_BACSU
Sequence: MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYDLSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YuzN.
Protein: RL332_MYCCT
Sequence: MRSSTNKKATLVCVECLSRNYSVNKSGLTQKQRLEIKKFCTTCNAHTLHKETR
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: FLAC_CAMJE
Sequence: MMISDATMMQQNYYLNNAQKASDKALENIAAVRAISGVDSANLAIADSLRSQSSTIDQGVANAYDAIGVLQIADASLTNISQSADRLNELSVKMNNAALNDSQKGMLRTEATRIQESINDSFNNATYNGKNVFQTMNFVVGSGTETTNLNPLATDGLSIDSQDSITNFMDQLGSLRSEIGSGINAITSNINASVQNSINSKAAENNLLNNDMAKNVNDFNANYLKENAAAFVAAQSNMQLQSKIANLLQ
What is the function of this protein?
Plays a role in virulence.
What are the official names of this protein?
Secreted flagellin C.
What are the subcellular locations of this protein?
Secreted. Note=Not detected in flagellar preparations, requires the flagellar export apparatus (FlgF) for secretion. SUBCELLULAR LOCATION: Host cell surface. Note=(Microbial infection) Binds to the surface of human HEp2 (ATCC CCL-23) cells.
Protein: CP086_HUMAN
Sequence: MASAGAERRPGVQEATVVGQGQLTEEPGSAQTSECPVAGDQFLVPAHEARGTQSEDQRPAGAASESELQEEGPKLGEERPKPHAGALEERGPRPVVSIVRPRHGPKRKPVKSLSLPGLRAHLKAEAELPPKLPLQEEEPEDSQSEPSPSAKQHKKAKKRKSLGAPVLHAVASMVSAPLETLRLERKAQRLRPLYQYVNYCNPELNQAGKGDGEAEVEAEAELAPVPEEGGVEQLQALLPLAGELGPGLALPCPSPLVTPTHALAPLGEEAGEEPGGLPSLGVSDHKAEVDKSTQVDIDKMLSVCTAPLVPPLSPQYK
What are the official names of this protein?
Uncharacterized protein C16orf86.
Protein: Y1925_STRPJ
Sequence: MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDHTLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNVASPYYLDEEALKYIDYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFSEAYVNIWYKRYVELKNR
What are the official names of this protein?
UPF0374 protein SPN23F19250.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: PNGA_ASPTN
Sequence: MNKKLKLFSMPGAQTSQIVIMLFQSLLHLLEAIASREPTRYIITYSIGNTHTPEIFSYSDLLQSARKAAGALRFKYHVVPGSVVLLHFNDHWNSMLWFWATLIADCIPAMSTPFSNNPETRLRHLKHLSTTLRSPKCLTTASLAAEFAGQEYITPICVQSLDYENLVHLPIKEGGDIAVLMFTSGSSGHCKVVPLTHEQILASLSGKAWTFPLPDNTAQLNWVGMNHVASLVEVHLFSIYTHSDQVHIPTVEVLSHVTLFLDLIHRHRVSRTFAPNFFLAKLRAALSADDTLAKYTGSLSNLRYIVSGGEANVTQTINDLAQMLKKCGAVSNVIVPAFGMTETCAGAIYNTSFPQYDVEHGLPFASVGSCMPGIQVRIVQLNGNGNSVPPGTVGNLEICGPVVLKGYFNDPAATKSTFTNDNWFKTGDLAFVDDNGMLVLAGREKDSIIVNGANYSPHDIESAIDEANIPGLISGFTCCFSTFPPSADTEEVIIVYLPNYTPADTVRRSETAAAIRKVAMMSVGVRATVLPLDRTMLEKSTLGKLARGKIKAAYERGDYKSYQEANEQMMALHHKVSHHQPRSGLEQSLLGVFTRTIPENLTEDFDVLTSIFDLGITSIELLKLKRGIEDLIGHGQIPLITLMTNPTIRTLSDALKQHAQQRDCSIYNPVVVLQSQGKKPPIWLVHPVGGEVMIFMNLAKFIIDRPVYGLRARGFNDGEDPFHTFEEIVSTYHASIKEKQPSGPYAIAGYSYGAKVAFDIAKALEHNGDEVRFLGLLDLPPSLNGTQMRAVAWKEMLLHICRMVGVIREEGIKKIYPRLEPENISPRHAIETVMGEADVTRLAELGLTASALERWANLTHALQRCIVDHKTNGSVAGADAFYCDPMASMAISNEQWACDYIGKWSDHTRSPPRFHHIAGTHYTILDAENIFSFQKTFLRALNDRGI
What is the function of this protein?
Nonribosomal peptide synthetase that mediates the biosynthesis of phenguignardic acid (PubMed:26851300, PubMed:29305695).  PngA alone is sufficient for phenguignardic acid synthesis (PubMed:26851300, PubMed:29305695).  PngA first activates phenylpyruvic acid (PPA) through its A domain to AMP-PPA (PubMed:26851300, PubMed:29305695).  The PPA unit is then loaded to the T domain and eventually transferred to the TE domain (PubMed:26851300, PubMed:29305695).  Another PPA unit is then loaded onto the T domain (PubMed:26851300, PubMed:29305695).  The TE domain likely promotes the enolate formation on the attached unit, followed by a nucleophilic attack on the carbonyl to yield an ether linkage between the two units (PubMed:26851300, PubMed:29305695).  Finally, the TE domain probably catalyzes a similar reaction to give the cyclized dioxolanone core and releases phenguignardic acid (PubMed:26851300, PubMed:29305695).
What are the official names of this protein?
Nonribosomal peptide synthetase pngA, Phenguignardic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: DBND1_MOUSE
Sequence: MESPEGAGPGEIVKDVKVPQAALNVSAHETGDMCRTPVAEEEEEVGIPIPAPGFLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDDENLATESPAGLHPLSRASCLRSPSWTKTRAEQNREKQPPSDPERQGTIVDTFLTVEEPKED
What are the official names of this protein?
Dysbindin domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the dysbindin family.
Protein: C1S_HUMAN
Sequence: MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED
What is the function of this protein?
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.  C1r activates C1s so that it can, in turn, activate C2 and C4.
What are the official names of this protein?
Complement C1s subcomponent, C1 esterase, Complement component 1 subcomponent s.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: TAL_DESHY
Sequence: MEFLLDSANPEEIRQAWAMGVIGGITTNPSLVAKEGRDFHQLLQELVQIVNGPISAEVIALDTEGMLGEARELAAMHPNIVVKIPMTEEGLKAVKVLKAEGIKTNVTLVFSAVQALLAARAGATYVSPFLGRLDDIGENGLLLLADICEVFGVHGLETKVIAASIRNPVHVTEAAKIGADYATVPFNVLCQLFKHPLTEAGIKKFLADWQKLK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM34_CRYNJ
Sequence: MSFVFPSWSTAFSPAFHEDAKAMLEGALNKGDKPPVIQGKIEVVELHMGEQPPTLTLLEIGDLSIDRFRGILRLGYQGDAWLEVRCRVQANPLSHNPHLTFSTLPLSTPLLASQPLLVPMTLRLSKLHLRAILILVVSASKGITLVFKNDPLQNVDVSSTFDSVEVIRGYLQQEIEGQLREMFREHLPGIIHRLSQKWFSGSGVGGKVEMPYRDMSPVPSYAPINEEVEEEENEENHGTSPGNEESFPPRHIGPGGITLPLNNSVSQLAALSYSAHTLSPYARGHEHIAVRSFPYLGKSGAGTGSSGRASLASSSVGEGDIKAKRKRIFRIGKSKEADEKSEA
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 34.
What is the protein family that this protein belongs to?
Belongs to the MDM34 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: QUEA_STAAE
Sequence: MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLNDTRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECIKEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTAGLHFTDELLIEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLNDTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLPKSTLVMLVSAFSSRENVLNAYKTAVNLEYRFFSFGDAMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEPA_EBVB9
Sequence: MMETPAESVRARVSSVTFYNVTQTAGRWWAIWVVGIVPIKREDVETLIVVQACQPPLGGSLEPPVVNAPSTTELNFLRWERELRRSGGLIAMLADAAEKDLFDLSFRTRDRRLLSAARVEDEQGLIFQPLFPAQVVCQSCSGDDGRDQQPPPVDGFGSEMEGEQTCPHAQRHSESPGQLDVYIRTPRGDVFTYSTETPDDPSPVPFRDILRPVTYEVDLVSSDGATGRGGDARRHRVSLKILEPAGGFESWLVNSWSMAGGGLYAFLRSIYASCYANHRGTKPIFYLLDPELCPGGSDFQPYVPGFPFLPIHYVGRARPAFWHRAPHSEGLLLLDLNLGVSGTPLADALLGLDARSGQRRGSLLLQQIWPPTRKEINPRHVCTREGGEGGGEDETTVVGRAEATAILEADATWWLYELARCHLSARGAPVGTPDGGGQARDAQTWLRALHRYGTSDTRRALGGLYTAVTRVLLHAAADLGLTWAYADEFILGFVAPTSAHPSEEPLAQAFLQGVKDSEDASRLDRDVMGGEATVARRHIRVKARRGPGCLLMAIFQGDLYVGGCREHSGPFLVWHEAFSWTLDQLAARPEADKAPPSHDHLLTLVRDLTRRLAPGRRRNRFWALPRAWLQRLRRAGLRLSGSHVCLLDKDGARPAPCQTATEHGLSPTAYFREIMAFLLDVISALHPGYTIPMEITRETDLLMTVLSLF
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs.  The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
What are the official names of this protein?
DNA helicase/primase complex-associated protein, HEPA, Primase-associated factor.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HEPA family.
Protein: PYRH_SACS2
Sequence: MMNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRYIKLAREIGIGEAYLDLLGIWASRLNAYLVMFSLQDLAYMHVPQSLEEFIQDWSHGKVVVTGGFQPGQSTAAVAALVAEASSSKTLVVATNVDGVYEKDPRIYADVKLIPHLTTQDLRKILEGSQSVQAGTYELLDPLAIKIVERSKIRVIVMNYRKLNRIIDILKGEEVSSIIEPV
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor.  Is also able to phosphorylate dUMP, although much less efficiently.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AUSR_ASPCI
Sequence: MLRLMHPFSAQPNEGVGLYILWTVAVLFVIFKLLAPAKCDLPTVNGRRRFEIGQYQARRRFALDGRGIILNGLRKARAFRVVSQKGPKIILGPEFADEVKSHPACNADVFIAKEFHAHVSGFEVLRPQQVMKDAIRLKLTRSIGVLMKPMSAETALILETQWGNSDCWHELDLKSTIASLVSRVSAVMFVGEELGRDQKWLSIVTNYSSDMFVADLDLCKWPEALRPIATYFLSSCGKLRRHIREAALMLDPILSERYSAPHNKHNFLDWFEEVAGGRKYNPVLAQLSLAAAAIDTTSDLIIQTLTDICRFRDSGKLQQDLREEMVRVLRADGWEKSAMYNLKLLDSVLKETQRVKPVVVFGMGRYVTEQMTLHDGTVIPQGETINVVNTRVWDSAVYPNPLEWDPYRFVRRRDSGDHAAHLVSPTPDHMGFGLGKHSCPGRFFAATKIKILLCHILLKYDVKISDEASSTVVSSGNFLFPDATLSFCVRRRQDNLTIWG
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of calidodehydroaustin, a fungal meroterpenoid (PubMed:28233494, PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:28233494).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (PubMed:28233494).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:28233494).  The cytochrome P450 monooxygenase ausR then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:28233494).  The hydroxylation catalyzed by ausR permits the O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:28233494).  The short chain dehydrogenase ausT catalyzes the reduction of the double bond present between carbon atoms 1 and 2 to convert 7-dehydrodehydroaustin into 1,2-dihydro-7-hydroxydehydroaustin (PubMed:28233494).  AusQ catalyzes not only an acetylation reaction but also the addition of the PKS ausV diketide product to 1,2-dihydro-7-hydroxydehydroaustin, forming precalidodehydroaustin (PubMed:28233494).  Finally, the iron/alpha-ketoglutarate-dependent dioxygenase converts precalidodehydroaustin into calidodehydroaustin (PubMed:28233494).
What are the official names of this protein?
Cytochrome P450 monooxygenase ausR, Austinoid biosynthesis cluster protein R.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NRAM_INBMF
Sequence: MLPSTIQTLTLFLTSGGVLLSLYVSASLSYLLYSDILLRFSSKITAPTMTLDCANASNVQAVNRSATKEMTFLLPEPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESDGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVKYDGDPWTDSDALAPSGVMVSMKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: H2AB1_CYRHA
Sequence: MKVTLIAILTCAAVLVLHTTAAEELEAESQLMEVGMPDTELAAVDEERLFECSVSCEIEKEGNEDCKKKKCKGGWKCKFNMCVKV
What is the function of this protein?
Postsynaptic neurotoxin.
What are the official names of this protein?
U4-theraphotoxin-Hhn1t, U4-TRTX-Hhn1t, Hainantoxin-II-28, HNTX-II-28.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 12 (Hwtx-2) family. 02 (Hwtx-2) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPG_CHLTB
Sequence: MATPCIQNAFRRKTLPVRIGDLFVGSEHSIKIQSMTTTATTDVDGTVRQICALQEWGCDIVRVTVQGLREVHACEHIKDRLIQQNISIPLVADIHFFPQAAIHVVDCVDKVRINPGNYVDKRNMFTGKIYSDEQYAHSLEHLMNKFSPLVEKCKRLGKAMRIGVNHGSLSERVTQRYGNTIEGMVYSALEYAEVCVAMDYHDVIFSMKSSNPKVMVAAYRSLAYELDQREWSYPLHLGVTEAGSGTAGIVKSAVGIGTLLSEGLGDTIRCSLTGSPINEIPICIDLLKQTTELSERWGEADNPFAIHSSKQLGTRNTLNTPPWGNVYGLLINLTDVQLLTAEPIELLQCLGIDTTTGKIDPTTPEGVVVPKAMRSSPIVSEIEKHLLVFNKEDAPILNPMNEEEWLSEETLSAPFVYFEVTDIHTARRFFSLRQHSTQPVCLSFSLDPHLSKNEAIIDLSARLGALLLDGLGSCVLLDFVDIKLSRTLGFLILQSANIRSVTVEYVSCPGCGRTLFDLLAVSQRIRERTKHLPGGLKIAVMGCIVNGPGEMADADFGYVGSKPGMIDLYVKHKCVKSCIPIENAEEELVQLLKEHGVWKEPE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: PYRB_CAUSK
Sequence: MTAKAPPAPHDPARAIDPILERIFSFPRRHFLSAGDLNAPQATDLLDLADAFVAFNRQTSKSLDILKGRTLMNLFFENSTRTQSSFEIAGKRLGADVVNMSPRTSSITKGETLIDTAVTLNAMRPDLLVVRHASSGAASLLSQKVSGSVINAGDGQHEHPTQAVLDALSIRRAFGRVSGLTVAICGDVLHSRVARSNVALLHTLGASVRLVGPPTLMPAQAERWGVTVHHDMKAGIAGADVVMMLRLQLERMQGAFVPSTREYFRFYGLDREKLARAAPKAKVMHPGPMNRGVEIDSDVADDPEISLIQDQVEMGVAARMAVLASLAHRLEEHGQ
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: SELO_CLOPS
Sequence: MDNKNFQSKTGFNLENTYLTLPNIFFSEQNPKGSKNPKLIKFNTSLAKELGLNEEILNSDFGLNIFAGNETFPGITPIAQAYAGHQFGHFTMLGDGRALLLGEHVTKDGKRYDVQLKGSGRTIYSRGGDGKAALAPMLREYIISEGMHSLGIPTTRSLAVVSTGEEVLREKFEQGAILTRIASSHIRVGTFAYAAQWGTLEDLKSLADYTIKRHFPNIANSENKYILFLEEVINRQAELIVKWQSVGFIHGVMNTDNMVISGETIDYGPCAFMDTYDTNTVFSSIDYAGRYAYGNQPNMALWNLARFSEALLPLLNPNLDEAVNIAKKSISSFSKLYKKYWFNKMRAKLGLFTKKENDELLIEGLLSTMQKYEADFTNTFVSLTLNKFEDEKVFSSNEFKTWYALWKDRLKEENRPKEEVRNLMMNNNPYIIPRNHLVEEALKNAEKGDFTFMDNLLEALKNPYSYSKDLEKYTKLPEKSDIPYVTYCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: GLUQ_PSEPG
Sequence: MTNSSYIGRFAPTPSGFLHFGSLVAALASWLDARAVNGRWLLRMEDTDPPREMPGARDAILQTLERYGLEWDGEVVFQSQRHDAYAAVVDRLFNMGLAYACICSRKQLEGYNGIYPGLCRNAGHAREGAAIRLRVPELIYRFTDRVQGEYQQHLGREVGDFVIQRRDGLYAYQLAVVLDDAWQGVTDIVRGADLLDNTPRQLYLQELLGFSQPRYLHIPLIVQPDGHKLGKSYRSPPLQVEHATPLLLRALRALGQDTDPELLVATPAEVLAVARKQWRPEAIAQKTTVPEADLR
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: PURL_METS3
Sequence: MTLTDSEMEYIEGILGRKMNELEEGMLDVMFSEHCSYKSSRPILGTFPTEGENIILGPGDDAGLVSVTDKYALAVGMESHNHPSAIEPYGGAGTGIGGILRDIISMGARPIALLDSLRFGSLDDEKSKYLFEHVVEGISDYGNRVGVPTVAGEVEFDDSFRTNPLVNVMCVGLVEKDKIVRGKAPYVGDVFLLMGGTTGRDGIHGVTFASEELTSDSETEDRPAVQVADPFTKKRVLEASLEILDEINVSGVKDLGGGGLTCCISELVDESNNGARVDLRNIPLRETGMTPYEIMLSESQERMVFVINPKDVKKAQEICDKHEIVSAVIGEVIDGNNMIIDDEGSSLADLPTILLADPPSLNRELKEIAEDTSKVEVDHPPVRQSLLELLSSPNIASKQWVYKQYDHEVQVRTVVKPGDDAAVLRIDDDTAIALTTDANTIHTKLSPFDGGAGCVAEAIRNVISMGATPYAVVDCLNFGNPETPEILWQFKRTIEGMSLVAENFNAPVISGNVSFYNETEGIKINPTPAVGVIGVENIENIRTMDFKNSGDKILLIGTTYDEVTGSEYHRTIHNIEKGMAPRIRIEDELANGKTILKLLDEDSSKNITAVHDVSHGGLAVALSEMVMKGNIGCEIDLDSIITSEDLEESDLIYSESHGRYIITVNADAVDEILNKIDVPVAIIGEVKGAVLKLGDNEFTIDELNDSYHGVIEKYMA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.