PharMolix/UniProtQA huggingface dataset:
Protein: NTF3_TOBAC
Sequence: MATPVEPPNGIRTPGKHYYSMWQSLFEIDTKYVPIKPIGRGAYGIVCSSVNRETNEKVAIKKINNAFENRIDALRTLRELKLLRHLRHENVIALKDVMMPIHRRSFKDVYLVYELMDTDLHQIIKSSQTLSNDHCQYFLFQLLRGLKYLHSANILHRDLKPGNLLINANCDLKICDFGLARTSSGKDQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPVFPGTECLNQLKLIINILGSQREEDIEFIDNPKARKYIKSLPYSPGTPFSRLYPHAHPLAIDLLQRMLVFDPSKRISVIEALQHPYMSPLYDPNTDPPAQVPINLDIDEDLGEETIREMMWSEILEYHPEAATAAMEVVL
What are the official names of this protein?
Mitogen-activated protein kinase homolog NTF3, P43.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: SECY_STRLI
Sequence: MLTAFAPAFKTPDLRKKLLFTLGIIVVYRLGTHIPIPGVDYKNVQECVDQASGNQGLFGLVNMFSGGALLQITVFALGIMPYITASIILQLLTVVIPRLEALKKEGQAGTAKITQYTRYLTVALAILQGTGLVATARSGALFSGCTVAGQIVPDQAIFTTVVMVICMTAGTCVVMWLGELITDRGIGNGMSILMFISIAATFPSALWAIKKQGELADGWIEFGTVILVGLVMVGLVVFVEQAQRRIPVQYAKRMIGRRSYGGTSTYIPLKVNQAGVIPVIFASSLLYIPALIVQFSNSTAGWATWITKNLADTAATPHIILYFFLIVFFAFFYVAISFNPEEVADNMKKYGGFIPGIRAGRPTAEYLSYVLNRITWPGSLYLGLIALVPTMALAGFGANQNFPFGGTSILIIVGVGLETVKQIESQLQQRNYEGFLR
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AAEA_YERP3
Sequence: MSTFSLKIIRVGITVLVVVLAVIAIFNVWAFYTESPWTRDAKFTADVVAIAPDVSGLLTEVPVKDNQLVQKGQILFVIDQPRYQQALAEAEADVAYYQTLAAEKQREFSRRHLLGIQALSQEEIDQASNVLQTVQHQLAKTIAVRNLARLDLERTTIRAPAEGWVTNLNVHAGEFINRGATAVALVKKDTFYILAYLEETKLEGVKPGYRAEITPLGSNRILHGTVDSISAGVTNSSSSADSKGLATIDNNLEWVRLAQRVPVKIHLDSEDQQYLYPAGTTATVVITGPNDRDPHQASPMTKLMHRLREFG
What is the function of this protein?
Forms an efflux pump with AaeB.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeA, pHBA efflux pump protein A.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ACEA1_MYCTE
Sequence: MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH
What is the function of this protein?
Involved in the persistence and virulence of M. tuberculosis.  Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.  It also catalyzes the formation of pyruvate and succinate from 2-methylisocitrate, a key step in the methylcitrate cycle (propionate degradation route).
What are the official names of this protein?
Isocitrate lyase 1, ICL1, Isocitrase, Isocitratase, Methylisocitrate lyase, MICA.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Protein: NUBP1_BOVIN
Sequence: MEEVPHDCPGADSAQAGRGASCQGCPNQRLCASGAGAAADPAIEEIKEKMKTVKHKILVLSGKGGVGKSTFSAHLAHGLAEDENTQVALLDIDICGPSIPKIMGLEGEQVHQSGSGWSPVFLEDNLGVMSVGFLLSSPDDAVIWRGPKKNGMIKQFLRDVDWGEVDYLIVDTPPGTSDEHLSVVQYLTAAHIDGAVIITTPQEVSLQDVRKEISFCHKVKLPIIGVVENMSGFICPKCQKESQIFPPTTGGAEAMCQDLKIPLLGKVPLDPRIGKSCDKGQSFLVEAPDSPATVAYRSIIQRIQEFCSQRLPEGENLVGS
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.  Implicated in the regulation of centrosome duplication.  Negatively regulates cilium formation and structure.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NUBP1, Nucleotide-binding protein 1, NBP 1.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell projection. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non- motile cilia. Localization is independent of NUBP2 and KIFC1.
Protein: CTAA_HALH5
Sequence: MHRSLKIFGTLTSIGMVIVLMQGALVTKTESGEGCGATWPLCFGEVIPTNPAIETIIEYSHRIVSGLLGAMVIILAIWAWRKLSHIRETKVMAILAVLFIIFQGLLGAGAVVFGQSHAILALHFGISAISLATVVLLTTLAFEDGKPNPPALIVKKGYKGYILAVFAYCYAVIYTGAYVKHTQATLACGDFPLCNGQWIPMLSGPVGAHFFHRVAGTLLLILLVVALIWTLRKYSHYRSLVWTHILCVILVLTQYATGISIVLTGNELFVAMMHALIVSILFTTLCYIVMILSRNKAV
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
Protein: NO16_MEDTR
Sequence: MASSSPILLMIIFSMWLLISHSESTDYLIGDSHNSWKVPLPSRRAFARWASAHEFTVGDTILFEYDNETESVHEVNEHDYIMCHTNGEHVEHHDGNTKVVLDKIGVYHFISGTKRHCKMGLKLAVVVQNKHDLVLPPLITMPMPPSPSPSPNSSGNKGGAAGLGFIMWLGVSLVMMMFLI
What is the function of this protein?
May act as a carbohydrate transporter.
What are the official names of this protein?
Early nodulin-16, N-16.
What is the protein family that this protein belongs to?
Belongs to the early nodulin-like (ENODL) family.
Protein: FADA_YERE8
Sequence: MENVVIIDAVRTPMGRSKGGAFRQVRAEDLSAHLMREVLSRNPELNAAEIDDIYWGCVQQTLEQGFNIARNASLLAEIPHSVPAVTVNRLCGSSMQALHDGARAIMVGDAQVSLIGGVEHMGHVPMNHGVDFHPGMGRTVAKAAGMMGLTAEMLAKIHNISRQSQDEFAVRSHQRAYAATQADHFAKEIVATNGHDADGILKRFDFDEVIRPETNLAGLAALRPAFDPVNGTVTAGTSSALSDGASAMLIMSESRAKSLGLTPRARIRSMAVVGCDPSIMGYGPVPASQLALKRAGLKLEDIGLFELNEAFAAQSLACLKGLGLLESMDDKVNLNGGAIALGHPLGCSGARISTTLLNLMERRDVQFGLATMCIGLGQGIATIFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_PSEAE
Sequence: MILELDCGNSLIKWRVIEGAARSVAGGLAESDDALVEQLTSQQALPVRACRLVSVRSEQETSQLVARLEQLFPVSALVASSGKQLAGVRNGYLDYQRLGLDRWLALVAAHHLAKKACLVIDLGTAVTSDLVAADGVHLGGYICPGMTLMRSQLRTHTRRIRYDDAEARRALASLQPGQATAEAVERGCLLMLRGFVREQYAMACELLGPDCEIFLTGGDAELVRDELAGARIMPDLVFVGLALACPIE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.  Can utilize a wide range of phosphoryl donors other than ATP, and does not discriminate between purine- and pyrimidine-based nucleotides or deoxynucleotides.  Is responsible for the resistance of P. aeruginosa to the pantothenamide antibiotics, since it cannot bind and phosphorylate these pantothenate analogs.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTMR6_MOUSE
Sequence: MEHIRTTKVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAQQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRIVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDTERRNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYPRELYVPRTASRPVIVGSSNFRSKGRLPVLSYCRQGTEAAICRCSQPLSGFSARCLEDEHLLQAISKANPGNRYMYVVDTRPKLNAIANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGSKGLSVNDFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDPREVSPVFTQFLECVWHLTQQFPQAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLDDKKKYLNPLYSSKSQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLSIIMNMNEQSKQLEEDIKDLEAKIKQCKNGILTKELLHAVHPESPALKTSLCLKEPSLLPVKDTLRAIEGSSPADNRYCDYAEEFSKSEPTVVSLEYGVARMTC
What is the function of this protein?
Phosphatase that acts on lipids with a phosphoinositol headgroup.  Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate.  Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity).  Negatively regulates ER-Golgi protein transport (By similarity).  Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580).  Acts as a negative regulator of KCNN4/KCa3. 1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate.  Negatively regulates proliferation of reactivated CD4(+) T-cells.  In complex with MTMR9, negatively regulates DNA damage-induced apoptosis.  The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (By similarity).
What are the official names of this protein?
Myotubularin-related protein 6, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum. Note=Localizes to ruffles during EGF- induced macropinocytosis (PubMed:24591580). Colocalizes with MTMR9 to the perinuclear region (By similarity). Partially localizes to the endoplasmic reticulum (By similarity). Co-localizes with RAB1B to the endoplasmic reticulum-Golgi intermediate compartment and to the peri- Golgi region (By similarity).
Protein: VIAA_ECO24
Sequence: MLTLDTLNVMLAVSEEGLIEEMIIALLASPQLAVFFEKFPRLKAAITDDVPRWREALRSRLKDARVPPELTEEVMCYQQSQLLSTPQFIVQLPQILDLLHRLNSPWAEQARQLVDANSTITSALHTLFLQRWRLSLIVQATTLNQQLLEEEREQLLSEVQERMTLSGQLEPILADNNTAAGRLWDMSAGQLKRGDYQLIVKYGEFLNEQPELKRLAEQLGRSREAKSIPRNDAQMEAFRTMVREPATVPEQVDGLQQSDDILRLLPPELATLGITELEYEFYRRLVEKQLLTYRLHGESWREKVIERPVVHKDYDEQPRGPFIVCVDTSGSMGGFNEQCAKAFCLALMRIALAENRRCYIMLFSTEIVRYELSGPQGIEQAIRFLSQQFRGGTDLASCFRAIMERLQSREWFDADAVVISDFIAQRLPDDVTSKVKELQRVHQHRFHAVAMSAHGKPGIMRIFDHIWRFDTGMRSRLLRRWRR
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.
Protein: SYI_BURVG
Sequence: MSNKKADSKPQAKYPVNLLDTPFPMRGDLPKREPQWVKEWEERGIYEKIRAASKGRPKFILHDGPPYANGDIHLGHAVNKILKDIVVKSRNMAGFDAPYVPGWDCHGMPIEIQIEKQFGKSLPAAEVMSKARAYATEQIEKQKVGFKRLGVLGDWANPYKTMNFVNEAEEIRALGKIIEKGYVYRGLKPVNWCFDCGSALAEAEVEYKDRTDPTIDVMFAFAEPEKTAQAFGLPALPRADGGIVIWTTTPWTIPANQALNLHPEIVYALVDTERGLLIIAEERVEACMADFKLTGRIVATAPGVKLANLRFHHPLASAHPGYKRTAPVYLGDYVTTDTGTGVVHSSPAYGIEDFVSCKSHGMTDSDIINPVMGDGRYIESLPLFGGLSIWDANPKVVEALRAAGSLLRSEKYTHSYMHCWRHKTPIIYRATSQWFAGMDVTPHAGGKTLRETALEGIDATAFYPSWGKQRLFSMIANRPDWTLSRQRQWGVPMAFFVHKETGELHPRTLELLEEVAKRVEQSGIEAWQSLDPRELIGDDANLYEKNRDTLDVWFDSGTTHWHVLRGSHKDQLQFPADLYLEGSDQHRGWFHSSLLTASMIDGRAPYKGLLTHGFTVDGEGRKMSKSLGNGIDPHEVANRLGAEIIRLWIASTDYSGELAISEEILKRVTEGYRRIRNTLRFLLANLSDFDFAQHAVPVDEWLEIDRYAVAFSAQLQTELLGHYEKYEFHPVVAKLQTYCSEDLGGFYLDVLKDRLYTSAADSRARRSAQTALYHLTQGLLRVLAPFLSFTAEEAWKVFQPASDTVFTETYYAYPEVAGAAALIEKWALLRDVRGNVTKALEEARTANRIGSSLQAEVAVHASGARYDALTSLGDDLKFVLITSAASVVKVDDEAHESVDVAASKYQKCERCWHYREDVGAHAEHPTLCGRCFSNLFENGEIRSAA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_LEGPC
Sequence: MIPWNAYVRLLRLNKPIGILLLWYPTAWALWMANQGFPSIDLLMIFLFGTVFMRSAGCVINDIADRHIDRHVARTQFRPLTSGEVSLSEAFILLFILLCASLLLLLKLPINCFYFAVISVLITFLYPFCKRFLNAPQLILGLAFSMGIPMAFIASGKNLNSDFIVLFLINFSWIIAYDTMYAMTDKADDLKIGVKSTAIYFASYDRLIIALLLIFLHSLWLVWAINKNAEWFFYLLWCTAAGILTYQLKLIYARIPKNCFKAFLVSGYYGLVMWFAVGLALI
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRAC_MOUSE
Sequence: IQNPEPAVYQLKDPRSQDSTLCLFTDFDSQINVPKTMESGTFITDKTVLDMKAMDSKSNGAIAWSNQTSFTCQDIFKETNATYPSSDVPCDATLTEKSFETDMNLNFQNLSVMGLRILLLKVAGFNLLMTLRLWSS
What is the function of this protein?
Constant region of T cell receptor (TR) alpha chain.  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens.  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation.  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
What are the official names of this protein?
T-cell receptor alpha chain constant.
Protein: HPI_ANCCA
Sequence: MSSYLLVLVAILGFAYAEGDYSLCQQREKLDDDMREMFTELHNGYRAAFARNYKTSKMRTMVYDCTLEEKAYKSAEKCSEEPSSEEENVDVFSAATLNIPLEAGNSWWSEIFELRGKVYNKNGKTSNIANMVWDSHDKLGCAVVDCSGKTHVVCQYGPEAKGDGKTIYEEGAPCSRCSDYGAGVTCDDDWQNLLCIGH
What is the function of this protein?
Hookworms inhibitor of platelet aggregation and adhesion (PubMed:10191228).  Native protein inhibits platelet aggregation induced by ADP, epinephrine, and thrombin (PubMed:10191228).  In addition, it prevents adhesion of resting platelets to immobilized fibrinogen and collagen (PubMed:10191228).  May act by binding to glycoprotein IIb/IIIa (ITGA2B/ITGB3) and integrin alpha-2/beta-1 (ITGA1/ITGB1), respectively (PubMed:10191228).  It is noteworthy that the recombinant protein fails to inhibit binding to fibrinogen (through ITGA2B/ITGB3) and collagen (through ITGA1/ITGB1) (PubMed:10191228, PubMed:26057788).
What are the official names of this protein?
Hookworm platelet inhibitor 1, HPI-1.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECU_STAES
Sequence: MNYPNGKPYSKNKPLDGRKSSPFSSNIEYGGRGMTLEKDIEQSNTFYLKSGIAVIHKKPTPVQIVNVHYPKRSKAVINEAYFRTPSTTDYNGVYNGYYIDFEAKETKNKTSFPLNNIHAHQVEHMKNTYHQKGIVFLMIRFKSLDEVYLLPYSKFEKYWQRYINNIKKSITVEEIRKNGYHIPYQYQPRLNYLKAVDKLILDESEDRV
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_AZOSB
Sequence: MPQYRSRTSTAGRNMAGARALWRATGMKDGDFEKPIIAIANSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHTADALVCISNCDKITPGMLMAALRLNIPTIFVSGGPMEAGKVKWEAKIIPLDLVDAMVKAADKNCSDEEVDAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHADREKLFREAGRRIVDLAKRYYEKDDATVLPRAIASFAAFENAISLDVAMGGSTNTVLHLLAAAKEAGVDFTMKDIDRISRHVPCLCKVAPAVPDVHIEDVHRAGGIMSILGELDRAGLLNRDVPTVHSKTLGEALGRWDIMQAHDKAVFDFFLAAPGGVPTQVAFSQNRRWNELDMDRAKGVIRNKANAFSQDGGLAVLYGNIAEKGCIVKTAGVDESIWQFTGKARVYESQEDAVEGILGEQVQAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKECALLTDGRFSGGTSGLSIGHASPEAAMGGAIALVEDGDTIEIDIPNRRIALAVSDEELARRRAAMEAKGAAAWKPANRERVVSAALQAYAALTTSADTGAVRDITQVQR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: BFR2_CANGA
Sequence: MGKLLADKLGKLANKPVVGDVDIEDDRVFEHRESGSDSDMDSGDEELKKAHYAQVGESKLRKQLDSEKNLQELDTKYVGSVGSREDIYGENASSGSDSGSDSELEDDESDAPANDLQSNDESESVESESEESDHESGSESDNGEVLRKIVEKETRQAMNRISDLTKRDASKGYSILSQNKFFENILDTRIKLQKAMNSANVLPVTKASWKLELKEDSENKKLLEENLSMVENLLNRVINFRIDIQAKEGISTDSKLETSKKRDITDLNESTDALDKDLKKYRTAVLQKWSAKVSSASGSSAMKSSKFKAVNQSADAQVENQLADTPRLIKRTCLNRRNVLPINFTEDMEQGRLTKFESTSNTGENNDEDENADIPKNYDPRRKDNNAIDISTNPYIFDDGDFYRVLLNDLIDKKTSSANLGVTSSATNSAIIVSKSNYKLKKNVDTKASKGRKLNYSIQEPIANYEAPVSSGYKWSDEQIDEFFAGLLGQKINFNEDSEQDSESDVGDEEEAIKNDDIQIFA
What are the official names of this protein?
Protein BFR2.
What is the protein family that this protein belongs to?
Belongs to the AATF family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MINC_ERWT9
Sequence: MSQSPIELKGSSFTLSVIHLHHTDPAIVRNALEEKVSQAPAFLKNAPVVINVAALSREINWRQMQQAILATGLHIVGVSGCKDERLKQTIARSGLPVLNEGKEQKNSADTPPIAALPVQTTAKTRLISTPVRSGQQIYAKDCDLIITSSVSAGAELIADGNIHIYGMMRGRALAGANGDKNCQIFCTSLSAELVSIAGNYWIMDQIPAEFFGKASRLCLQDGALTIQALN
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: NMD3_HUMAN
Sequence: MEYMAESTDRSPGHILCCECGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWIQCALESRELLALCLKKIKAPLSKVRLVDAGFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQSQMCGDCHRVEAKDFWKAVIQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPCRYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICVCIRVTSAIHLIDPNTLQVADIDGSTFWSHPFNSLCHPKQLEEFIVMECSIVQDIKRAAGAGMISKKHTLGEVWVQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLANCNLNDEHVNKMNSDRVPDVVLIKKSYDRTKRQRRRNWKLKELARERENMDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSAIPVESDTDDEGAPRISLAEMLEDLHISQDATGEEGASMLT
What is the function of this protein?
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
What are the official names of this protein?
60S ribosomal export protein NMD3, hNMD3.
What is the protein family that this protein belongs to?
Belongs to the NMD3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner.
Protein: IFRH_ARATH
Sequence: MATEKSKILVIGGTGYIGKFLVEASAKAGHSTFALVREATLSDPVKGKTVQSFKDLGVTILHGDLNDHESLVKAIKQVDVVISTVGSMQILDQTKIISAIKEAGNVKRFLPSEFGVDVDRTSAVEPAKSAFAGKIQIRRTIEAEGIPYTYAVTGCFGGYYLPTLVQFEPGLTSPPRDKVTILGDGNAKAVINKEEDIAAYTIKAVDDPRTLNKILYIKPSNNTLSMNEIVTLWEKKIGKSLEKTHLPEEQLLKSIQESPIPINVVLSINHAVFVNGDTNISIEPSFGVEASELYPDVKYTSVDEYLSYFA
What are the official names of this protein?
Isoflavone reductase homolog P3.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUTA_SHIFL
Sequence: MQDAAPRLTFTLRDEERLMMKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIAQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSIPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAARMKQATEQTGRDVGSYVLFMVIADETDDATRAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHLSALTQEVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.