PharMolix/UniProtQA huggingface dataset:
Protein: METK_STRA1
Sequence: MSERKLFTSESVSEGHPDKIADQISDAILDAILEQDPDAHVAAETAVYTGSVHVFGEISTTAYVDINRVVRNTIAEIGYDKAEYGFSAESVGVHPSLVEQSPDIAQGVNEALEVRGSLEQDPLDLIGAGDQGLMFGFAVDETPELMPLPISLAHQLVKKLTDLRKSGELTYLRPDAKSQVTVEYDENDQPIRVDAVVISTQHDPNVTNDQLHKDVIEKVINEVIPSHYLDDQTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNIVAADLAKKVEVQLAYAIGVAQPVSVRVDTFGTGVIAEADLEAAVRQIFDLRPAGIINMLDLKRPIYRQTAAYGHMGRTDIDLPWERVDKVQALKDFIASK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_MYCGE
Sequence: MNSFFPSRKLGQNFTVNLSVIKRIFAFVKNLNPQAIVEIGVGKGALTNYLLKLKIPYKGIEIDKRLIEYLLVEKILTEDQLVKGDILKKDFNSFFENLSPLLCGNIPYSITSPIINKFLESKLRSFVLMTQKEFANRLLAKVNSSDYSAFGAFCQYYLTITTVFKIDRHAFKPKPKVDSTLILLEKNKSVSYDFKFGLFLKQCFNQRRKMLINNLKHFFAVDYLLNIIQKQNLKTSIRAQELSPCQLFNLYQNICNGKN
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5562_BACC7
Sequence: MGNEFRMCDDCQATNVKTLIPKLKKVDSCATIEVGCQSYCGPGRKKSFAFVNNRPVAAPTEDELIVKIEAKLNK
What are the official names of this protein?
UPF0741 protein BCAH187_A5562.
What is the protein family that this protein belongs to?
Belongs to the UPF0741 family.
Protein: ORC1_DEBHA
Sequence: MAKSQRDLKGWQYFLDDAELNNTDSVNGEPTTPSRRSRRGKSTSSQKISLKREEDELEIKEGDFLLVQQDNNSPEVAIVKEIKFGNDNFLDIIVSWFIRMRDIEEADLPKVEEYKERSQLNENELFITSYLDEVKLGEIIDKVNILSEEEFNNDIVIDDSNKASTFICRRGCDSAGELFTDVFDFRDLCVLFEKNHHEFIEFIRRKTVPVAYNANKTHDKSKSIKDKLDEVETKKPKQKTVSKQILDEEEENNDSSDEFESAIDLQDEPSSDELESDEDASESKNKSPRKRKASSKPKAVKEKQKRVKIPNNHSKFDDESRQFITSVVSPLNKRMKIKDSSKPSILALSPRKPKKGVSKGENGKNGSLGVDASSEAFKELKEKLHTSTRLSSLPCREDEFTSIYLNLETAIQEQTGCCLYVSGTPGVGKTATVREVIAQLRELTEMGELNDFDYLEINGLKLLSPNVAYEKLWEKISGLKVTASNAALLLESYFSQDTPRKPLIVLMDELDQIVTKKQNVMYNFFNWPTYSNSKLIVIAVANTMDLPERVLSNKISSRLGLRRIQFIGYTFEQLGSIIKHRLDMLTKQNKRKVIINSDAIGFASRKVASVSGDARRALTICRRAVEIAEKDFLSSKEDPGNEQEIENESYHVQISHISKAINETVNSPISQFLMSLPFASKLVLAGVLLRMKRSGLAENSLGDIIDEMKNSLTMLTSRDGDKVLEAIDSKMTLIDLLYGNGLLQNLDSTFNSKDTNIRILRFKYIVNELVENGILQQNVRGERHSLINLNISEEEIVSVLKRDKEISSIL
What is the function of this protein?
Component of the origin recognition complex (ORC) that binds origins of replication.  It has a role in both chromosomal replication and mating type transcriptional silencing.  Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner (By similarity).
What are the official names of this protein?
Origin recognition complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the ORC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YLBN_BACSU
Sequence: MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKGRADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIVEDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLAALEKLLKQDDES
What are the official names of this protein?
Uncharacterized protein YlbN.
Protein: Y1082_PYRCJ
Sequence: MSKLGVVSWGAYIPRYRVRTEEVSRIWGDDPLRIVDMYLVDEKSVEGIDEDAVTIAVEAARRAIRRGGIDPRKIGAVYVGTESKPYAVKPISSILIDALGLTNNVFAVDMEFACKAGSDGLVAAIGLVEAGRVEYGMTVGTDTSQGEPGEHLEYSASSGGVALIVGKDGVAAELEAMYAFVSDTPDFWRREGSPYPMHGEGFTGEPAYFRHVIGAAKGLMEKYGYKPSDFTYVVFHQPNGRFPVRAASMLNIPLDKVKPGIVVTHIGNTYNASALMGFAKVLDIAKPGDKILLVPFGSGAGSNAFVFTVTDVVKDRQKMGVPTVEEMLQDKILVDYAQYLKMRKMIKLFE
What are the official names of this protein?
UPF0219 protein Pcal_1082.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. UPF0219 family.
Protein: MURE_CAMJE
Sequence: MKLKLENSFITDNTLECEKECFFLQTTQNAKFHAQALEKGAKIIDVNECKKLLKIDEKIQIIGITGTNGKTTTAAAIYSILLDLGYKCGLCGTRGAFINDEQIDEKSLTTSPILKTLEYLQIATQKKCDFFIMEVSSHALVQNRIEGLNFAAKIFTNITQDHLDFHGTFENYKEAKELFFTDESLKFINKDALAIKFNVRNAFTYGIENPALYQIKAYSLEEGISTIVTNKNQTFHIDSPLLGLFNLYNLLVASACVNELVKPDLKDLEKAISGFGGVCGRVEQVAKGVIVDFAHTPDGIEKVLDTLKNKKLIVVFGAGGDRDKTKRPLMGKIVEHFAKIAIITSDNPRSEEPKTIMEEILSGFTKKEKVLMIEDRKEAIKKALELKENDDLVVILGKGDETTQEIKGIKYPFSDKVVVNEILKNQG
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLA4_MACLB
Sequence: MGRSISVSFGLLVVFLSLSGTGADQDCLPGWSSHEGHCYKVFNLNKTWEDAKKFCTEQANSGHLVSIDSKKEANFVAELVSQNIKETRRTDFVWIGLRAEDKRQHCSSEWSDGSSINYQNWIEAESKKCLGLEKQTRYRKWVNLNCGQPYRFTCEI
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec A4, C-type lectin A4.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: MDH_YERPS
Sequence: MKVAVLGAAGGIGQALALLLKTQLPSGSDLSLYDIAPVTPGVAVDLSHIPTAVNIKGFSGEDATPALQGADIVLISAGVARKPGMDRSDLFNVNAGIVRNLVEQIARTCPNALIGIITNPVNTTVAIAAEVLKKAGVYDKNKLFGITTLDTIRSNTFVAELKGKQPQDIEVPVIGGHSGVTILPLLSQIPGVSFTEQEVADLTKRIQNAGTEVVEAKAGGGSATLSMGQAAARFGLSLVRALQGESNVVECSYVEGDGKYARFFAQPILLGKNGVAERKDIGKLSAFEQQALENMLDVLHKDIELGEKFVNQ
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: PEX1_SCHPO
Sequence: MRCIVSYKSLRSCLVNVPELLLESISEPVQNYAVQAVVCKNDIKKTFYFGISGIPSQFSFEIDSTYAHTLKLAENQEINLSIIDCTHEIEQLEIEPVTSNDWEIAERNAAWLEENLLVQYRVATTERFIIYLPSGTFIQFQPLKLIPSSLCGRLLRTTEVLITPKPNTSAIEVKENRKVNLRCVVENRLLPDSVTADSPALCVFLPLNFPDRPDVVYMDGGNLKSTIVCQCVSCPFQIPGHFFISKSLALSYSIKTGFKFQIWKAHNPPSSSKFILEQKGLPPESNLSSELVAAKLKNSYLMDGMTLKLVDIAVSYSVSGLSGVVKNPIQDIKITSDTNVPVNAGIRNNSPRLSMQPFPHEFAQVRNAVFLHQNIYINGPKGCGKSNLVHSLFDYYSLNSIYFQMIVSCSEIDRSSFAKFQSFWNNVFIQAERYEPSIIYLDDVHCLISSSNENGELGFVEEREIAFLQHQIINLKRKRKIIFIGFGEEFLTFSENLVLPLLFQIKIALPSLAVTRRKEILTTIFQENFSDITMDSIEFISVKTEGYLMTDLVLFVKRLLSEAFVEKIQNGPKHLMNKGLIEKTLKDFVPLQLRKAKFVKSSIRWIDIAGMQEAKEAVRDIIESPVKYSLIYKQCRLRLPTGILLFGYPGCGKTYLASAISSTFPVQFISIKGPELLDKYIGKSEQGVRDLFSRAQMAKPCVLFFDEFDSVAPRRGQDSTGVTDRVVNQILTQMDGAESLDGVYIVAATTRPDMIDPALLRPGRLDKLIFCDLPNEEERLEVLQKLANRFHIENAAMLKKLSTLTDGYTYADLSSLLYDAHLIAVHKLLKRVSINAVDPSQTTSSFTNLTTESKRNASMLALPPESRYNQNMQSMSDSKSVVIEDYMLMEALKKNSPSLNSEEFEHLSNLYRDFRSKLFEPELNARNTDVGSKTRQI
What is the function of this protein?
Component of the pex1-pex6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the pex5 receptor from peroxisomal membranes, an essential step for pex5 recycling.  Specifically recognizes pex5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the pex2-pex10-pex12 retrotranslocation channel.  Extraction by the pex1-pex6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from pex5.
What are the official names of this protein?
Peroxisomal ATPase pex1, Peroxin-1, Peroxisome biogenesis protein pex1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACTC_HUMAN
Sequence: MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, alpha cardiac muscle 1, Alpha-cardiac actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: COAX_ENDTX
Sequence: MFLALDIGNTNITVGLFAMKDKKVLPEPLKVWIMSTVKERTFDEYATLLMNMLFYDGFDAKQLSNFAVASVVPSLNAVFEELIKKYFGEKTFFVNSKNCGGLVFAAGNSKETGADRIANVVAAYSVYGDSCIVIDFGTATTFDCINSEGIYIGGAIAPGPSISARLLNLKTEQLPRVEVKKPLKSIGLTTVECMQSGLYFGYTGLVKELIARIKNEMKIKHIIATGGLAGLMFDEIEEIEIILPYLTLSGVRIVWEKVI
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEM3F_MOUSE
Sequence: MLVTAFILWASLLTGAWPATPIQDQLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECILSGKDGNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQALPWTQMQVVRGRGSRATDGADRPTPTAPRQDYIFYLEPEKLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQNPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQRRPLVVRTGAPYRLTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPSDRRREIRAEDRFLRTEQGLLLRALQLGDRGLYSCTATENNFKHIVTRVQLHVLGRDAVHAALFPPLAVSVPPPPGTGPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPRPREAPGALRPPELQDQKKPRNRRHHPPDT
What are the official names of this protein?
Semaphorin-3F, Semaphorin IV, Sema IV.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YSCS_YERPE
Sequence: MSQGDIIHFTSQALWLVLVLSMPPVLVAAVVGTLVSLVQALTQIQEQTLGFVIKLIAVVVTLFATASWLGNELHSFAEMTMMKIQGIR
What is the function of this protein?
Component of the Yop secretion machinery.
What are the official names of this protein?
Yop proteins translocation protein S.
What is the protein family that this protein belongs to?
Belongs to the FliQ/MopD/SpaQ family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IRF9_MOUSE
Sequence: MASGKVRCTRKLRSWIVEQVESGHFPGVCWDDAAKTMFRIPWKHAGKQDFREDQDAAIFKAWALFKEKHKDGDIGHPAVWKTRLRCALNKSSEFEEVPERGRMDVAEPYKVYRILPAGTLPNQPRNQKSPCKRSISCVSPEREENMENGRTNGVVNHSDSGSNIGGGGNGSNRSDSNSNCNSELEEGAGTTEATIREDPVFLEHQLPLNSDYSLLLTFIYGGRVVGKTQVHSLDCRLVAERSDSESSMEQVEFPKPDPLEPTQHLLNQLDRGVLVASNSRGLFVQRLCPIPISWNAPEAPPGPGPHLLPSNKCVELFKTTYFCRDLAQYFQGQGPPPKFQATLHFWEESPGSSHSQENLITVQMEQAFARHLLEKIPEEEKAALFLLQHTEQSPSALGH
What is the function of this protein?
Transcription factor that plays an essential role in anti-viral immunity.  It mediates signaling by type I IFNs (IFN-alpha and IFN-beta).  Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2.  IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus.  ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
What are the official names of this protein?
Interferon regulatory factor 9, IRF-9, IFN-alpha-responsive transcription factor subunit, ISGF3 p48 subunit, Interferon-stimulated gene factor 3 gamma, ISGF-3 gamma, Transcriptional regulator ISGF3 subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the IRF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIHI_VIBC3
Sequence: MSRSKKSRKPGTNSNDQLVVVRTRSESELESRLRKKLKKRKGLKSGSRHSEGSESQVRQAAQKRDPRLGSKKPIPLIVAEPKKLNKQERKLAAEQELAMLEKDAQLNVLLDRLDNGEKLGIGLQKYVDEKLDRIEVLMEQLGLLDDEPEPAPAPQSKPTKKRKTEDDLLSEFEQLDVDKYQD
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: PHNC2_RUEST
Sequence: MLRINKLTKRFGDKTAVETATLDIDKPCMLGIIGRSGAGKSTLLRMINRLGDATEGSISFEGREITTLKGKDKRAWQSECAMIFQQFNLVPRMDVVSNVLHGTLNRRSTLATVFNLYPMADIHKAIEILDRLGIAEHAPKRAEALSGGQQQRVAIARALMQDPKIILADEPIASLDPMNAQTVMEALRRIHEEDGRTVIANLHTLDTARRYCDRVVGMRDGRIVFDGLPEQLTTGVAREIYGAGADFSEAATSTAIETLEQTDAVRTAEAYV
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YDW1_SCHPO
Sequence: MDQEIRSNNYDISVSTVEDTSFEAMDDSILEIIDDEAPEIQGKPKANISTHFRNMLAMFGNFLSLGFFLVIIVLVGIAFEIGGRFCGLILTLALEVYFFSTALLKLFGLRKIALTLHFFEPLLVFILLIIALNASPSIEQNKYASFLASAWNTALLHFTPLFNLLEGMASLLVVQALGHLSRWLVHNKSENWMFFILLNASSAISMSLYLLYRVSSFSISNPNALMIGFSLATVIVISIYGVASGRANLSEASLMFLYIAYTVYMVCTDFGNPNTSSLEKPKFDYLPPNILQSVHYLISTISATLPRTLYNIVLFMVAAAKTVAPSVFATFAFRISVMYAVTRILPAIQNNIIFLEYSRTSKQGMWSILSPCILIAVYTNLLLQHLYPTPSFTSPVNQILCSAEIWRWVSAILTLLLYAIELAYSKESDTGQALASHFKLD
What are the official names of this protein?
Uncharacterized protein C23C11.01.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RBG1L_CHICK
Sequence: MEVRTSFSKARRIPEAVSTLINEEFVVVHQQTEDSSGKDAKPQLKVFSNGDDQLEKAMEEILRDSEKDQNNSTALPEGSSDACSQASGLGSGGQTNQPSLQLVLDPSTTEVSARRSSSPSEPLEEDSVLFNKLTYLGSMKVSAPRNEPEALRAMANMKSSSQAPLSVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCVRGQNGTSESDCFAFTESSCGTEEFQIHVFSCEIKEAVSRILYSFSTAFKRSSKQASDHVKDFVLHTPDSDVYTFSVSLEVKEDDGKGNFSPVPKDRDKLYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSSDGKAYVITGIWNPNAPMFLVLNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFYMKLKQSEGKSHTSAGDPIYEVASLQRESAREEQLLSPTSGGGPVSSQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLVVRPNGLSTLVKRGVPEALRAEVWQLLAGCHDNEAMLDKYRILITMDSAQENVITRDIHRTFPAHDYFKDTEGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVFVKIMYDYGLRDLYRNNFEDLHCKFFQLEKLMQEQLPDLYSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGMNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEREYQTMRESQLQQEDPMDRYKFICL
What is the function of this protein?
GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity).  Plays a role in endocytosis and intracellular protein transport.  Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells.  Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
What are the official names of this protein?
Rab GTPase-activating protein 1-like.
What are the subcellular locations of this protein?
Early endosome. Golgi apparatus. Note=Colocalizes on endosomes partially with EEA1 (By similarity). Colocalizes and cotransports on motile vesicles with ANK2 (By similarity).
Protein: DAPD_YERPG
Sequence: MQQLQNVIETAFERRADITPANVDTVTREAITHVIDLLDTGALRVAEKIDGQWVTHQWLKKAVLLSFRINDNQVMEGAETRYYDKVPMKFAGYDEARFQREGFRVVPPATVRKGAFIARNTVLMPSYVNIGAFVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFVGARSEVVEGVIVEEGSVISMGVFIGQSTRIYDRETGEVHYGRVPAGSVVVSGNLPSKDGSYSLYCAVIVKKVDAKTRSKVGINELLRTID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MACB_NEIMB
Sequence: MSLIECKNINRYFGSGENRVHILKDISLSIEKGDFVAIIGQSGSGKSTLMNILGCLDTAGSGSYRIDGIETAKMQPDELAALRRERFGFIFQRYNLLSSLTARDNVALPAVYMGAGGKERSARADKLLQDLGLASKEGNKPGELSGGQQQRVSIARALMNGGEIIFADEPTGALDTASGKNVMEIIRRLHEAGHTVIMVTHDPDIAANANRVIEIRDGEIISDTSKNPEIPASNVGRIREKASWSFYYDQFVEAFRMSVQAVLAHKMRSLLTMLGIIIGIASVVSVVALGNGSQKKILEDISSIGTNTISIFPGRGFGDRRSGRIKTLTIDDAKIIAKQSYVASATPMTSSGGTLTYRNTDLTASLYGVGEQYFDVRGLKLETGRLFDENDVKEDAQVVVIDQNVKDKLFADSDPLGKTILFRKRPLTVIGVMKKDENAFGNSDVLMLWSPYTTVMHQITGESHTNSITVKIKDNANTQVAEKGLTDLLKARHGTEDFFMNNSDSIRQIVESTTGTMKLLISSIALISLVVGGIGVMNIMLVSVTERTKEIGIRMAIGARRGNILQQFLIEAVLICVIGGLVGVGLSAAVSLVFNHFVTDFPMDISAMSVIGAVACSTGIGIAFGFMPANKAAKLNPIDALAQD
What is the function of this protein?
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NACB_NEOFI
Sequence: MDQAKLARMQASVRIGTFYSFLWIFEVLVSESVFLRMTATNFIDRGKGTPRRKVKKVHKSSGADDKKLQTTLKKMNVQPIQAIEEVNMFKEDGNVIHFAAPKVHASVPSNTFALYGNGEEKELTELVPGILNQLGPDSLASLRKLAESYQNMQKQAGTEGKKDEDEDDIPDLVEGENFESNVE
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit beta, NAC-beta, Beta-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-beta family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: ARPC2_DROME
Sequence: MILLEINNRIIEETLLVKYRNAQAGLKPESIDIRIADFDGVLYHISNVNGDKTKVRISISLKFYKQLQEHGADELLKREYGSLLTDTEEGYNVSVLINLEEIPEDCEQIAKRIGLLKRNCFASVFEKYFDYQEQGEEGQKRAVINYRNDETLYVEAKPDRVTVVFSTIFRDEDDVIIGKVFMQELREGRRASHTAPQVLFSHREPPLELANTDARVGDNIGYVTFVLFPRHTNKETRDNTINLIHMFRDYLHYHIKCSKAYIHSRMRAKTSDFLKVLNRARPEPKNTEKKTITGRTFKRID
What is the function of this protein?
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the mother actin filament (By similarity).
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TFB2_SCHPO
Sequence: MQAEFKSSINDFLEQLPNHARLYQKPAACLAVFRLLPILARQYVMSMLFNPMPVALSDFDLWIKLSSKVYQSESFNKLVRMHIFQFDGQYITLNSEFRKQFITALTGGGNHNSFGVPCTDEDKHLVTVDFLDAYAKETWETILHFMVGTPEAKFPGEGVLSLLKRGGLMSGPKNQLRITRAGFQFLLQDINAQIWTLLLDYLKLSEDTHMDPVQVLHFLFMLGSLDLGRAYSVDFLTDTQQIMLEDLREYGLVYQRKITSKRFYPTRLATGLTTDYRSLHGKQSENDDDKGFIIVETNYRLYAYTSSPLQIAIIGLFANLRARFSNLVVGVITRDSIRRALMNGIAAEQIITYLTTHAHPQMRSNVPLLPPTLVDQIYLWELEKNRLRATPGILFRDFLTDSGFDQAVEYAKELGVLVWDSSLKRMFFITTTGAQPMIAYLKRRAVK
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit tfb2, TFIIH subunit tfb2, RNA polymerase II transcription factor B subunit 2.
What is the protein family that this protein belongs to?
Belongs to the TFB2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y3331_CYTH3
Sequence: MGNLFYFILAAFCEISGCYLFWLHFRSDKPALLLLPAAACLLVFAYLLTKIDTATAGRAYAVYGGIYIVCSLAWMYGIEKFSPDIWDYIGVGICLIGASVILFAPR
What are the official names of this protein?
UPF0060 membrane protein CHU_3331.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SOTB_ECO57
Sequence: MTTNTVSRKVAWLRVVTLAVAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGIMLTIYAWVVALMSLPFMLMTSQVERRKLLICLFVVFIASHVLSFLSWSFTVLVISRIGVAFAHAIFWSITASLAIRMAPAGKRAQALSLIATGTALAMVLGLPLGRIVGQYFGWRMTFFAIGIGALITLLCLIKLLPLLPSEHSGSLKSLPLLFRRPALMSIYLLTVVVVTAHYTAYSYIEPFVQNIAGFSANFATALLLLLGGAGIIGSVIFGKLGNQYASALVSTAIALLLVCLALLLPAANSEIHLGVLSIFWGIAMMIIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSMIGYVGTVPAFAALIWSIIIFRRWPVTLEEQTQ
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.