PharMolix/UniProtQA huggingface dataset:
Protein: RPOZ_GLAP5
Sequence: MARVTVQDAVEKIGNRFDLILTAARRARQLQLHTREPLVAEEGDKPTVIALREIEEGLINNQIMDQQEKFDAIVQEVAEKEAISFLADVQANS
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: NADD_BRUAB
Sequence: MTVGLFGGSFNPPHGGHALVAEIAIRRLKLDQLWWMVTPGNPLKDSRELAPLSERLRLSEEVAEDPRIKVTALEAAFHVRYTADTLALIRNANPDVYFVWVMGADNLASFHRWQRWREIAQNFPIAIIDRPGSTLSYLSSRMAQTFSDSRLDERYAPVLARRMPPAWTFIHGPRSSLSSTALRKVQLKKAPSKK
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: NU1M_MYXGL
Sequence: MISQIISSFLTFVMILIAVAFLTLIERKVLGYMQLRKGPNIVGPFGLLQPFADGIKLFIKEPLQPSYASIFLFILAPALAISLALILWISLPLPLALSDMNLGLMFILAISSLSVYSLLTSGWASNSKYALMGALRAVAQTISYEVTLGLMIVALTILSGGFDLKLFIDLQNKIWLLFPMWPIFLMWFISTLAETNRSPFDLTEGESELVSGFNVEFSGGLFALFFLAEYANILFMNSLTVVLFMGSSNLSSLYFSASMTMKTMFLIFLFLWVRASYPRFRYDQLMHLMWKNFLPITLSLLIFQFSMSLFFGVSPSAI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GLNB1_METBA
Sequence: MQMIRAIIRPGMETKVIECLEKEGCISLTKMEVFGRGKQKGIHIADISYDELQKTMLLMVVEDEHKDRAIKTIMESARTGKYGDGRIFVTPVEEAYTIRTGKPGL
What is the function of this protein?
Could be involved in the regulation of nitrogen fixation.
What are the official names of this protein?
Nitrogen fixation nifHD1 region GlnB-like protein 1, ORF-105.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: NDOR1_CANAL
Sequence: MTGEITILYGSETGNAEEYAKYLKQRLRSYNLKPINLASLDDYPLKRLVTHTSYLIIICSTTGQGEIPRNGKKFMKFILKKKLPSDLFQHLQLTTFGVGDSSYVKYNYAIKKIHTRLMQLGCQLLSPRCEADEISPEGVDGYYIEWEAELIAALLNKFPSASKISSEAVPMPEYRISVSKSDTTIDPKEVIDNPIVSRLGKDGLKLGTVLENNRLTSSNHFQDVRDFKFSSNGLNYLPGDTVSLFPCNFDEDVDALLQSQPQWLKIADKPLNLKNFPHLEGGFADILTLRTLFKYHLDIMSIPRRSFFALLWHFVDPSTEDGEREQEKLKEFGSLDEPEELYDYANRPRRSILETLLEFENNLTIPVSYILDLFPLIRPRMFSIASCPSSKEVELVVAIVEYKTIIRKIRRGVCTRWLKNLKPGDQFLFSIQRSSFKYKDDNSPIIMVAPGTGIAPMKSLIDEVIQNNSKQELYLFFGCRFKEKDNLIESFWHGNENQNLHLVSAYSRDSNSKYRYVQDALFAHSELIGKLLIEQNAKVFVCGSSGKMPREVKITFVEIVKKFTGMDEGDAQKYIIGLEDNGRYKEDAW
What is the function of this protein?
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery.  In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.  Positively controls H(2)O(2)-induced cell death.
What are the official names of this protein?
NADPH-dependent diflavin oxidoreductase 1, NADPH-dependent FMN and FAD-containing oxidoreductase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion. Note=Relocalizes to mitochondria after H(2)O(2) exposure.
Protein: RS9_XYLF2
Sequence: MPITQNYGTGRRKSSTARVFLRKGSGNISVNGRPLDEFFGRETARMIVRQPLELTKNVSNFDILITATGGGTTGQAGAIRLGIARALVEYDTSLKPELRKAGFMTRDPREVERKKVGLHKARRATQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: AQP2_HUMAN
Sequence: MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:8140421, PubMed:7524315, PubMed:7510718, PubMed:15509592).  Plays an essential role in renal water homeostasis (PubMed:8140421, PubMed:7524315, PubMed:15509592).
What are the official names of this protein?
Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity).
Protein: CR021_BOVIN
Sequence: MRQKHYLEAAAWKLQDSCPGQARYLLWAYSSSHDDKSTFEGTCPYCCQLLVQDKSRVRLKPKPKLTPKIQKLLNREARNYTLSFKEAKILKKYKDSKSVLLITCKTCNRTVKHHGKSRSFLSALKSNPTTPTSKLSLKTPERKTPSSANLNHTSGSKGKSPALIFRTPTSGQSTSICSSKNASKTKKHFSQLKMLLSQSESKKNPKMDFRNFLSSL
What are the official names of this protein?
UPF0711 protein C18orf21 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0711 family.
Protein: CYSI_MYXXD
Sequence: MSHQPKPLSEVEHIKTQSRLLRGSLAESLEDPVTGGLATPDTNLIKFHGSYQQDDRDVREERRQQKLEPDYSFMLRTRLPGGVCTPAQWLVMDALAREHANHTLRITTRQAFQLHGVIKDDLRPTIARINEAMMDTLAACGDVNRNVLCNPNPVDSRVHETVYQWAVRISEHLLPKTRAYYEVWLGKEKVAGGEDEPIYGATYLPRKFKAAVAVPPLNDVDVFAQDLGFIAIIEGDALVGFNVSVGGGMGATHGDAATYPRLADVVGFIPPEQTLAVAEEVVKIHRDFGDRTNRKHARLKYVLEERGVPWFTAELEKRLGFPLQPARPFAFEHNGDRFGWTEGHDGRWHLTLHLDSGRVADRPGAPHLTGLREIARIHTGDFRLTANQNLVIAGVTPEARDAIGALVTAHALDSFRSASPVRRNALACVALPTCGLAMAEAERYLPTFVGRLEDRLRAHGLQDANLLLRITGCPNGCARPYLAEVGLVGKAPGRYNLHLGGDARGQRLSHLYRENIDEDAILAALEPLFEGYARERQPGEGFGDFVVRAGHVPSPAVQPRPS
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: CUL8_YEAST
Sequence: MINESVSKREGFHESISRETSASNALGLYNKFNDERNPRYRTMIAELHEFFHLTLAETITETDVKELECNKEKAAKFRKLMPKMLNNCRELTQRKSYIPYNSEFNGNDEKQKKFQLLHQHQIVLSFQEFCDELAKLIIDAHVLSFLTRCDYSYEIIPKNWTSFYKLFQYVMGAVGPIISYVPVNYPMIRKELGFETLTIFQYYDSKLFECMKSHFGREFSTLVSATIHHYIHMFPITNTMLEKEVPMLRIMSNCNFSIEGLSPKDFYMKTLRQYYCEESNLRPRLETFKNFKVLLTRNALLASLFSPEWVSDANDLFISHLLLNKKSISEYIEIGKDTYDEEKERYFKTETHFSLLMFRNAFEAKNMLSKFKEFCDDAVSEKLKAAYGSNHDTERLFDEVVQLANVDHLKIYSDSIEYHLCNLLGSTSKAIEQYVKYFESHLFIIVRKIKTTKKDLPRDMKIKYLNENLPILRLKFVNLPTFPNFFERSIFRKTILQSDQNSSFIKDILPVYKDSLMELFKQRIITNVSQEDEMRYRDQYQPYLSQFFQPVEVMADLRIKYASFLSFYENIEAAVKFGKTYNENNSKSFFPLIFDRERIPKVFQQSNEVKKNFVLPQEMDDTWNQFLRNYHEQNKVEDSDASKKELYPMWNLHHCEVESPYIIQDGTNLIFELTLFQTCVLTLFNESDHLTLQVISEQTKLAYKDLALVLKSFCNYKILTRDIDNTYSINESFKPDMKKVKNGKLRVVLPRTASLQSSNTGGERTSSAHHEGSNSQWTQELLKACITRSVKSERNGLDYDHLFETVKQQIKGFSVGEFKDALAKLLRDKFITRDESTATYKY
What is the function of this protein?
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins.  As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.  The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme.  The functional specificity of the CRL depends on the type of the associated substrate receptor protein.  RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks.  RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125.  Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition.  RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase.  RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles.  Ubiquitinates the FACT (facilitates chromatin transcription) complex subunit SPT16 in an MMS1-independent manner.  Involved in regulation of Ty1 transposition and protects the genome from Ty1 integration upstream of tRNA genes.
What are the official names of this protein?
Cullin-8, Cullin-C, Regulator of Ty1 transposition protein 101.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Recruited to chromatin in response to replication fork stalling.
Protein: ATG8C_ORYSI
Sequence: MARSSFKLEHPLERRQAEANRIREKYPDRIPVIVEKAERSDIPDIDKKKYLVPADLTVGQFVYVVRKRIKLSAEKAIFIFVKNTLPPTAALMSAIYEENKDEDGFLYMTYSGENTFGLFV
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.
What are the official names of this protein?
Autophagy-related protein 8C, Autophagy-related ubiquitin-like modifier ATG8C.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor. Cytoplasm, cytoskeleton.
Protein: SEY1_PLAF7
Sequence: MEKGVEKTQIIDYDGNVIEDLKEWMIDNKLNDLGFSYNVIAVLGSQSSGKSTLLNNLFKTSFDVMNTKQGHSQTTKGLWLSYDKFDDETNNSSSFFKLKKKNKPTLILDVEGTDSKERGDNRLTFEHRSALFCLALADCVIVNLWYHSLGNFTASNYGLLKTVMEVNLELFQQEKNSPKTILLFTVRDWFEEFAPIEVVRNKILDEYINKIWKEMKKPKEAEKLNINNFFIIEVVGLSHGIIKKEDFLKDVNNLRDKWINNLRPSKYSRNIPSDGFAQYCNNIWNTIVKQSQLDIPSQKEMLSTFRCQEIKNNVINNINKEIKEKSIESHNKVIENFKEWAEKNIIQKCLDDYFKDASRYKENICLRTSQELLDYLFTQLQAIVDNNLQYIQRTLCTKFFNELSNMYKICTIEKNTFSFSRDSNLKTVKDNNKNTSHEDIKRDLLNNNQDKCVHLWSNFLYNADKLEYFTFCNFYENYEKSNIEIKTNMKNDDNLKNDDNLKNDAHNNITTHQFNYKPTLSVLSTSIYKDSNRIRNIQCGILLNKTRQTIKNSFKNMDTYLLTTKNTEEYWNNTVQLVLKLQDNINTHLTKCFINLKGTNHNNLNIYNDDMMYNNDDMVFNNNDDDDNNNNNNNNNYYYYNKNDDANLSKDENYNNKFSFSLTNEKGIFQNINNNNEGSDEICYTNALKKIDLIKNKQVYKSTINEDINNKLQNKKYIHELKNYYLDEIMDVLKNKLDEISENLATIIIQRFESVFNYDEYEQPRQWRDISMAELKKIFLKSKNYAFLIIDILQKNIKVELIDDYLPNNFIKDEIIEKGKIKAKRRIQEICRDAQYIQETGSKMSLKNVPVVFWIILLLFGWNEILFFIRMFFKLNVILPLFFAAAFIVSTFVYNGNTQALSYINKIIFYMAKNSYNFFKHIQAISNPPPKNVQKQE
What is the function of this protein?
Probable GTP-binding protein involved in generating and maintaining the structure of the tubular endoplasmic reticulum network.
What are the official names of this protein?
Protein SEY1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYDND_BURVG
Sequence: MSMRTEYCGLVTEHLLGQTVSLCGWVQRRRDHGGVIFIDLRDREGLVQVVCDPDRGEMFATAEGVRNEFCVQIKGLVRNRPEGTVNAGLKSGKIEVLCHELIVLNASVTPPFQLDDDNLSETTRLTHRVLDLRRPQMQHNLRLRYRVAIEARKYLDEQGFIDIETPMLTKSTPEGARDYLVPSRVNAGQFFALPQSPQLFKQLLMVANFDRYYQITKCFRDEDLRADRQPEFTQIDCETSFLGEQEIRDLFEDMIRHIFKTTIDVELDAKFPVMPYSEAMARFGSDKPDLRVKLEFTELTDAMKDVDFKVFSTPANAKDGRVAALRVPKGGELSRGDIDGYTEFVRIYGAKGLAWIKVNEKAKGRDGLQSPIVKNLHDASIAAILERTGAEDGDIIFFAADRAKVVNDSLGALRLKIGHSEFGKANGLVEAGWKPLWVVDFPMFEYDDEDARYVAAHHPFTSPKDEHLEYLETDPGRCLAKAYDMVLNGWEIGGGSVRIHREEVQSKVFRALKIGAEEAQAKFGFLLDALQYGAPPHGGIAFGLDRIVTMMAGADSIRDVIAFPKTQRAQDLLTQAPSPVDERQLRELHIRLRQPEQPKA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_PSEA8
Sequence: MSVFTPLERSTLEAFLAPYDLGRLRDFRGIAEGSENSNFFVSLEHGEFVLTLVERGPVQDLPFFIELLDVLHEDGLPVPYALRTRDGEALRRLEGKPALLQPRLAGRHERQPNAHHCQEVGDLLGHLHAATRGRILERPSDRGLPWMLEQGANLAPRLPEQARALLAPALAEIAALDAERPALPRANLHADLFRDNVLFDGPHLAGLIDFYNACSGWMLYDLAITLNDWCSNTDGSLDPARARALLAAYANRRPFTALEAEHWPSMLRVACVRFWLSRLIAAEAFAGQDVLIHDPAEFEMRLAQRQNVEIHLPFAL
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: NB_MYCLE
Sequence: MPSDLCPDLQALAPLLGSWVGRGMGKYPTIQPFEYLEEVVFSHLDRPFLTYTQKTRAITDGKPLHAETGYLRVPQPGHIELVLAHHSDIAEIEVGTYSVTGDLIEVELVTTTIGLVPTAKQVTALGRFFRIDGDEFAYSVQMGAVGQPLQDHLVAVLHRKQ
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: RSMG_MYCLE
Sequence: MKHVGSYEELASFTSVKGNLGFDTVFEAVFMIFGPRLNIAQRYVDLLANTGIERGLLGPHEANRLWDRHLLNSAVVAELLDPGDRVVDIGSGAGLPGLPLAIARPDLQVVLLEPLLRRVTFLREVVAELGLDVEVVRGRAEELWVRDRIGERDVAVSRAVAALDKLTKWSIPLLRPGGQILAIKGEHVFDEIHQHRRVMASLGAVDVMVVVCGANYLCRPVTVVLTRCGQQMRHKPARVGDRKTQ
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase, Glucose-inhibited division protein B.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_FRAT1
Sequence: MKRKLKMDNLNINFINDDEHPIPSQDLLLKCLQLVANKHHISHAEVNLNIVSNDEIQQINKQFRNKDKPTNIISFEFEKPQGLPDDIANDFLGDIVIAPAVLENEAKEQNKELNDHWQHIFIHGLLHLLGYDHQDDQEAEVMENLEIQLLAQLGIANPYIEQENQNGR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATD_ECOLI
Sequence: MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGAHYYPITLGHEFSGYIDAVGSGVDDLHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMSAPQMQSVLRELRFNQLILETAGVPQTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHRGSFESFAQAVRDIARNAMPGKVLLIP
What is the function of this protein?
Converts galactitol 1-phosphate to D-tagatose 6-phosphate.
What are the official names of this protein?
Galactitol 1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: QCRB_MYCTU
Sequence: MSPKLSPPNIGEVLARQAEDIDTRYHPSAALRRQLNKVFPTHWSFLLGEIALYSFVVLLITGVYLTLFFDPSMVDVTYNGVYQPLRGVEMSRAYQSALDISFEVRGGLFVRQIHHWAALMFAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEGYFGYSLPDDLLSGLGLRAALSSITLGMPVIGTWLHWALFGGDFPGTILIPRLYALHILLLPGIILALIGLHLALVWFQKHTQFPGPGRTEHNVVGVRVMPVFAFKSGAFFAAIVGVLGLMGGLLQINPIWNLGPYKPSQVSAGSQPDFYMMWTEGLARIWPPWEFYFWHHTIPAPVWVAVIMGLVFVLLPAYPFLEKRFTGDYAHHNLLQRPRDVPVRTAIGAMAIAFYMVLTLAAMNDIIALKFHISLNATTWIGRIGMVILPPFVYFITYRWCIGLQRSDRSVLEHGVETGIIKRLPHGAYIELHQPLGPVDEHGHPIPLQYQGAPLPKRMNKLGSAGSPGSGSFLFADSAAEDAALREAGHAAEQRALAALREHQDSIMGSPDGEH
What is the function of this protein?
Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis.  The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain.  The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.  The cytochrome b subunit contains two ubiquinol reactive sites: the oxidation (QP) site and the reduction (QN) site.
What are the official names of this protein?
Cytochrome bc1 complex cytochrome b subunit, Cytochrome bc1 reductase complex subunit QcrB, Ubiquinol--cytochrome c reductase cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RK14_SOYBN
Sequence: MIQPQTHLNVADNSGARELMCIRILGASNRRYAYIGDIVVAVIKQAVPNTNLERSEVIRAVIVRTCKELKRSNGIIIQYDDNAAVVIDQEGNPKGTRIFCAIARELRQLNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: VPU_HV1MA
Sequence: QPLVILAIVALVVTLIIAIVVWTIVFIEIRKIRRQRKIDRLIDRIRERAEDSGNESEGDTEELSKLVEMGHDAPWDVDDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: MUTL_LISMO
Sequence: MAKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSGIEEEDVATAFLRHATSKIKNEADLFRVHTLGFRGEALPSIASVSHLAMETSTGETKGTSISLEGGKIIEQKSGHARKGTQIEVSQLFFNTPARLKYLKSLPTELGNITDILNRLALAHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGISIAKKSIPVKAESLDFKISGYAVLPEVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVHPAKLEVRLSKEKELGQLISQMIKEAFHKLQLIPEGEISKKQKEVQKSEQIQMSFEENKPAKEIPTLFSKPTIPEYVPSDEDAPREDDFILETMPPYEPQAEQEEHSKERIPKMYPIGQMHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPADEYVRLEEQKAKLEEVGVFLENFGQNSFIIRAHPTWFPKDQEEEMLREIIDEALSAPSISIHKLREDTAIMMSCKKSIKANHYLTTQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFKRVM
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: TUSA_PSEA7
Sequence: MTHPVDAILDATGLNCPEPVMMLHNKVRDLAPGGLLKVIATDPSTRRDIPKFCVFLGHELVEQQEEAGTYLYWIRKKAD
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y294_MYCGE
Sequence: MIVTTKKGFKKRLKDFSKQQILALIILGAIDVFVIAAPYYVKNVVPNLHLYLGITEDEVATVTSIIGYVTLATQLPGGFLTNRFSSRKLLFLSAITTGAITFWLAANILTKNQQSHDALFIQYCVIWGLWGITSTLIFWTPLWKLASQQATKENQALGFGIQGAANGIWGLIFIFLIALIITSIFYPSGGSENADSKPFAAYAFIIAIMLVITGFTVLFFVKEKPIEKQSQTTLVSFKRNLNQILVTLKNWKLWLLSFFLMGMYVFQSTFAYYLLQMLQNAFLAPVVLVTVIGGIRTYALRSAVSVYLCRLADKCKSYILFLMICTVLGIVFVLAFILLGFVQTNSANITLITFSSILYIFTGILSWGMVTVRYNQIGEIDIGKNNYASSVGLLSFIGFSTDGWLYTVTAEVGKKYTVAGQSNTSNTGYQIIAAICLSIALFGLICGSIVFISNSMEIKRLNKASYRWRDLDNA
What are the official names of this protein?
Uncharacterized protein MG294.
What is the protein family that this protein belongs to?
To E.coli YihN.
Protein: PLSY_PHYAS
Sequence: MVSIYFFFFFLLFYALGSFPTGLIIGKLTQKKDLRLVGSRNVGATNASRILGFKWGIVVFLFDFAKGLVPAIICLRFKNFKDLIFINGCDNRYKDIAICLLVILPIFGHMFSIFNKFKGGKAIATSVGVITAINPFIGLLGILFFVLLFIFVGYASLASIMATLLVDLLLFFINHHPGITNISQNQILYFFIGLSTCFIILKHHSNIIRLWQGKEYKFSFIKKRK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.