PharMolix/UniProtQA huggingface dataset:
Protein: TOP1_RICTY
Sequence: MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDKNFAMEYDISDKASKYVDAIVKYARKAEAVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKAEEYWDISLKMQNSNNELFTAKLTHVNDQKLKKFSIINEKEAKDLTRKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGNKYLPINPRIYQSKVKNAQEAHEAIRPTNITYTPDNLKQKLEKDYYKLYELIWQRTIACQMENVIMDLVIANLASENKEYLAKANGSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKAQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTSLNNFWSGFNNNIESVNEQKITEIINYLQKALDYHLFGENKESKVCPSCKTGQLSLKLGKFGAFLACSNYPECTFKKSIVSGNDNNEDEGNLSTILNDNKILGTDKDGVEIYLKTGPYGPYIQLGEQCGKVKPKRTPVPTNLKQSEITLEVALKLLSLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLNLDDAIKLIENNKAKLEKKHRSMV
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 1, DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: SDUA_BACC4
Sequence: MSDKINVWTTSRDSAVCGDIELKKTSTTRLIFRPEIVNNNKNPKASVRGCFIFQKKGRNALWDDYKELDMNKLKAEEWIKLEINSDAMLTLTKEIQKHYAVHEKYGVRYGAFHLFKDNPDIEKLIEMFESNTDLLTQLMEDDKSEALEKTLEWIVTNDNPDKIIDRLKNLKEQDLDQLNTLIGIANLKKVLSVWESNKLTNTSEKFWQSVLKENTWILSQIFSNPTVLINDEAYVGGKTVKNDSGKLVDFLYANPFSKDAVLIEIKTPSTPLITPTEYRTGVYSAHKDLTGAVTQVLTYKTTLQREYQNIDYNNYRQGIKTDFDIITPCCVVIAGMFDTLTDTAHRHSFELYRKELKNVTVITFDELFERVKGLIKLLEG
What is the function of this protein?
Only component of antiviral defense system Shedu.  Expression of Shedu in B. subtilis (strain BEST7003) confers resistance to phages phi105, phi29, rho14 and to a lesser extent to SPP1 (PubMed:29371424).  May be an endonuclease (Probable).
What are the official names of this protein?
Shedu protein SduA, Putative nuclease SduA.
Protein: CHVE_AGRFC
Sequence: MKSIISLMAACAIGAASFAAPAFAQDKGSVGIAMPTKSSARWIDDGNNIVKQLQEAGYKTDLQYADDDIPNQLSQIENMVTKGVKVLVIASIDGTTLSDVLKQAGEQGIKVIAYDRLIRNSGDVSYYATFDNFQVGVLQATSITDKLGLKDGKGPFNIELFGGSPDDNNAFFFYDGAMSVLKPYIDSGKLVVKSGQMGMDKVGTLRWDPATAQARMDNLLSAYYTDAKVDAVLSPYDGLSIGIISSLKGVGYGTKDQPLPVVSGQDAEVPSVKSIIAGEQYSTIFKDTRELAKVTVNMVNAVMEGKEPEVNDTKTYENGVKVVPSYLLKPVAVTKENYKQVLVDGGYYKEDQLK
What is the function of this protein?
Required for effective transcriptional induction of the vir genes by monosaccharides in response to plant signals and for normal growth and chemotaxis towards certain sugars.  Functions as a periplasmic multiple sugar-binding receptor protein.  It does not interact with a transport system.
What are the official names of this protein?
Multiple sugar-binding periplasmic receptor ChvE.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NUOB1_CERS4
Sequence: MAMTGLNTAGSDRDYDTQSLNRELQDKGFLLTTTEDLINWARTGSLHWMTFGLACCAVEMMHTSMPRYDVERFGVAPRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGILQLQRKIRRTGTITR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B 1, NADH dehydrogenase I subunit B 1, NDH-1 subunit B 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: KHSE_HAEIG
Sequence: MLRIYAPASSANISVGFDTLGAAISPIDGSLLGDVVQIESISTGFELESAGYFVRKLPKEPQKNIVYQAYVLFSEQLKLRGANVKPLRLTLEKNMPIGSGLGSSACSIVAALVALNQFHNEPFSKMELLEMMGELEGRISGSIHYDNVAPCYLGGVQFMVQSLGNICQKLPFFDNWYWVLAYPGIEVSTAEARAILPKSYTRQNVIAHGRHLGGFVHACHTHQENLAAIMMKDVIAEPYRESLLPNFAEVKQATRDLGALATGISGSGPTIFSIAPDLQTAIKLSSYLESHYLQNNEGFVHVCKVDNEGTREIK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSS1_SENVU
Sequence: MAESNKEAIDSARSNVFKESESLEGTCAKIGGYDFNNGIDHSKLLKSMVSTGFQASNLGDAMIITNQMLEWRLSHDEVPENCSEEEKKNRESVKCKIFLGFTSNLISSGVRETICYLTQHRMVDVLVTTTGGIEEDFIKCLASTYKGKFSLPGADLRSKGLNRIGNLIVPNDNYIKFEDWIIPIFDQMLIEQKTQNVLWTPSRMIARLGKEINNETSYLYWAYKNNIPVFCPSITDGSIGDMLYFHSVSNPGPGLVVDIVQDVIAMDNEAVHASPQKTGIIILGGGLPKHHICNANMMRNGADFAVFINTAQEYDGSDSGARPDEAVSWGKISSTGKAVKVHCDATIAFPLLVAETFAVKKEKASKVNGF
What is the function of this protein?
Catalyzes the transfer of an aminobutyl unit from spermidine onto putrescine.  The resulting polyamine homospermidine is a precursor in the biosynthesis of pyrrolizidine alkaloids.
What are the official names of this protein?
Homospermidine synthase.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: HIS6_BACC2
Sequence: MLAKRIIPCLDVKEGRVVKGVNFIGLQDVGDPVEIAEAYNEAGADEIVFLDITATHEGRKTIIDVVEKTAAKVFIPLTVGGGISSVKDMYNLLRAGADKVSINSAAVRNPKLIEEGAEHFGSQCIVVAIDARKVAEDKWNVYVNGGRVDTEMDAIEWAKRVVKLGAGEILLTSMDADGTKSGYDLRLTEEISKSVSIPVIASGGCGHTDHIIEVFQKTTVDAALAASIFHYGEATVQSVKRKLRDANVEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_CUPNH
Sequence: MARRNAASPQMGLDLAPAAAAVQRLCGVDEAGRGPLAGPVYAAAVILDPKRPIRGLADSKILTAAKREQLYEKICERALGWHIAFATVEEIDTLNILHASMLAMQRAVQGLAASGIVPDLVQVDGNRCPRVPFPVEAIVQGDALVKAISAASILAKVARDRELRVLHERYPQYGFDSHVGYGTPQHLAALAEFGATPHHRRSFAPVREALARLPMFTAMPATAEVIEPVATVSVTAAQ
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_STAS1
Sequence: MVAKILDGKQIAKDYRQGLKDQVEALQAEGYTPKLSVILVGNDGASQSYVNSKKKAAEKIGMISEIVHLDESTSEADVLNELKRLNEDDSVSGILVQVPLPDQVSEQKVLESINPAKDVDGFHPENIGKLYIDQQTFVPCTPLGIMELLNHADIDLEGKDAVVIGRSHIVGQPVSKLLLQKNASVTILHSRTKDMKRYLKNADIIVSAVGRPGLVTKEDVKEGAVVIDVGNTPDENGKLKGDIEYDEVKEVAGAITPVPGGVGPMTITMVLNNTLIAEKMRRGIE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: G6PI_DECAR
Sequence: MNPIDSPAWRALAAHAEAIRPLHLRDLFATDPQRFELFSLHHDGLLLDYSKQRVSVETMALLRAYAETADVTGWRRRMLDGESINHTEGRAVRHMSLRAGDQAPAEVRAALARQQAFCESIHNGVWRGFSGERITDVVNIGIGGSDLGPRMAALALSARQQPDIAVHFIANVDSADIAPLLASLNPRTTLFIVASKTFTTLETLTNARTARDWLLATAGQESAIARHFVAISTNLELTKQFGIADDNVFEFWDWVGGRFSIWSAIGLSLALAIGWKNFEQLQAGARAMDRHFIDTPADENLPLTLALLSLWNTNFLGASTEAMLPYSQSLHLFPAYLQQLEMESNGKQIDRDGKPLNIATSPVIWGESGTNGQHSFYQLFHQGGHLIPADFVALREADFPLPGHHASLLANCLAQSAALAFGQTAEEVRAAGIPEALIPYKVFPGNQPSNTLLLPSLDPYTLGQLLALFEHKVFCLGVLWNLNAFDQWGVELGKQLAGQLTPLIEGNGDLSAFDSSTRGLITALKG
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB2_DEBHA
Sequence: MSANTISTKVQSKDLNGLSLIAAHSHISGLGLDDNLQPKESGQGMVGQLKARKAAGVILKMIQAGKIAGRAVLVAGPPSTGKTAIAMGLSQNLGSEVPFTAIAGSEIFSLELSKTESLTQAFRKSIGIKIKEETEMIEGEVVEIQIDRSITGGHKQGKLTIKTTDMETIYELGNKMIEGLTKEKVLAGDVISIDKASGKITKLGKSFTRARDYDAMGPETKFVQCPEGELQKRKEVVHTVSLHEIDVINSRQQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDDFAPIVIMATNRGISKTRGTNYKSPHGLPMDLLDRSIIIHTAPYNADEIRTILLIRATEEEVELTGDALALLTKIGQETSLRYASNLISVSQQIALKRRSNSVDLPDIKRSYMLFLDSDRSVQYLEEFSTQFIDDSGNVTFGTNDASVKQTKGAANGEDKMETD
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 2.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GALT7_RAT
Sequence: MRLKIGFILRSLLVVGSFLGLVVLWSSLSSRPDDPSPLSRMREDRDVNNPLPNRGGNGLAPGDDRFKPVVPWPHVEGVEVDLESIRRKNKAKNEQERHAGGDSQKDIMQRQYLTFKPQTFTYRDPVLRPGVLGNFEPKEPEPHGVVGGPGENAKPLVLGPEYKQAAQASIKEFGFNMAASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLTEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPIIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPREKRLRKTKTEPYRSPAMAGGLFAIERDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPLYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESKALPYGDISELKKFREDHNCKSFKWFMEEIAYDITAHYPLPPRNVEWGEIRGLETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGPDGSKVMITHCNLNEFKEWQYFKNLHRFTHIASGKCLDRSEVLHQVFISSCDNGKMTQKWEMNNIHSV
What is the function of this protein?
Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide.  In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties.  Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
What are the official names of this protein?
N-acetylgalactosaminyltransferase 7, Polypeptide GalNAc transferase 7, GalNAc-T7, pp-GaNTase 7, Protein-UDP acetylgalactosaminyltransferase 7, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: PER56_ARATH
Sequence: MAALKMTISCFLFLQVIYCLLSSFAPTNVQGLKVGFYDKACPKAELIVKKSVFEAVKNDRTIAAPLLRMFFHDCFVRGCEGSVLLELKNKKDEKNSIPNLTLRGFEIIDNVKAALEKECPGIVSCSDVLALVARDAMVALNGPSWEVETGRRDGLVTNITEALLNLPSPFNNISSLITQFQSKGLDKKDLVVLSGGHTIGNGHCPQITNRLYNFTGKGDSDPNLDTEYAVKLRGKCKPTDTTTALEMDPGSFKTFDESYFKLVSQRRGLFQSDAALLDNQETKSYVLKSLNSDGSTFFKDFGVSMVKMGRIGVLTGQVGEVRKKCRMVN
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 56, Atperox P56, ATP33.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRE_THEGJ
Sequence: MIEAKDRLIDKMLESGAILFGHFVLSSGKESDYYINVKKVVTDPDALELMAGLIAGLVQRVGIDFDRVAGPELGAVPIATAVSLKTGKPLVIVRKKPKGYGTGSQIEGDVKEGDRILLVEDVTTTGGSVLRAAEVLESLGARIAAIAVVVDREEGAEGSITSKGYTFLPVIRVSELLERKETVKGRESD
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: O165_CONAA
Sequence: MCILIVAVLFLTAWTFVMADDPRDEPDTVVRGGKLFSRARDEMNPAASKLNERDCVEVDYFCGIPFVFNGLCCSGNCVFVCTPQG
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-conotoxin-like Am6.5.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL34_MESM1
Sequence: MKRTYQPKKRKHAKTHGFRSRMATKNGRKVLKLRRLKGRYQLTVSDK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: RS14_LISIN
Sequence: MAKKSKVAKHEHQQALVEQYAELRRTLKAEGRFDELRKLPRDSSPTRLHNRCELTGRPHGYMRKFGMSRIRFRELAHQGQLPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: MATK_PAECA
Sequence: MEKSQGYLELDKSWRHNFLYPLIFQEYIYALAHEQGLNRSILLENTDHDNKYSSLIVKRLITLIHQQNHFLIFDNDSNQNPFWKHNNNLYSQTISEGFVIIVEIPFSPRFVDSLEEKKKILKSNNLRSIHSIFPFLEDQILHLNFVANILIPYPIHLEIVVQSLRYRVKDASSLHLLRFFLFTLNKSISSFSKRNQRFFLFLYNSHVYEYESTFLFLRNKTSHLRSTSSGAFLERIFFYGKIKHLIEVFANDFQAILWLFKDPFMHYVRYQGKSILASKRTSLRMNKWKYYLVNFWQCQFYVWSQPGRVSINQLSNHSLDFLGYLSSVRRNPLAVRSQMLENSFLTDNAIKKFDIIVLLISLIGSLAKAKFCNVLGHPLSKPARADSSDSDIIERFVRICRNLSHYHSGSSKKKSLYRIKYILRLSCARTLARKHKTTVRSFLKRLGSELLEEFLTEDGQVISLIFPRTSSTSWRLYRGGIWYLDITCINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ALG11_XENLA
Sequence: MAGPMCLCGMMRLLTALFIPVLITSVGLCLIFVLLFICTRLWVQRKKKVEIGKDGKKKKVVAFFHPYCNAGGGGERVLWCALRSLQKRYKDAIYVIYTGDKDASEEQILNGAAARFNIKLSHPVRFIFLEKRGLVEASCYPRFTLLGQSLGSVVLGWEALTKCVPDIYIDSMGYAFTLPLFKYLGGCHVGCYVHYPTISMDMLSVVRSQHARFNNAAFISNNPVLSRLKLIYYYLFALFYGWVGSCSDVIMVNSTWTFSHILDLWKCSDRTSIVYPPCDVQTFLEIDINQHKENEEHSVVSIGQFRPEKDHPLQIRAFAALLEKKTAEQRAKLKLILIGGCRNDEDELRVSELKKLSSELGIPVEFKVNVPFEELKKHLSEATIGLHTMWNEHFGIGIVECMAAGTIILAHNSGGPKLDIVVPHEEQQTGFLADSVDSYAAAMDHILSLTPEQRLSIRQNARLSVGRFSDQEFEANFLASSEPLFK
What are the official names of this protein?
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase, Asparagine-linked glycosylation protein 11 homolog, Glycolipid 2-alpha-mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NUDI_ECOK1
Sequence: MRQRTIVCPLIQNDGAYLLCKMADDRGVFPGQWALSGGGVEPGERIEEALRREIREELGEQLLLTEITPWTFSDDIRTKTYADGRKEEIYMIYLIFDCVSANREVKINEEFQDYAWVKPEDLVHYDLNVATRKTLRLKGLL
What is the function of this protein?
Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
What are the official names of this protein?
Nucleoside triphosphatase NudI, Nucleotide diphosphatase NudI, Pyrimidine deoxynucleoside triphosphate diphosphatase, dCTP diphosphatase, dTTP diphosphatase, dUTP diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudI subfamily.
Protein: RL31B_PSEU2
Sequence: MKPDIHPQYRTVLFHDTAADAYFLIGSTVDTDRTQQHTDGTTYPYVALDVSSASHPMYTGQQRKATTEGRIAGFNKRFATFGSAGKKETAAAQ
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: FOLD_SOLUE
Sequence: MPRILDGNRVRDEIKGELKPRIAALAAHGRPPGLAVVLVGNNPASEIYVRNKIKTCHDLGIYSESITPPDTISTEELLAIVQGLNARAEIDGILVQLPLPPQVDTKRILMAVSPAKDVDGFHPCNVGALVANLPAPRACTPAGIMELLKRGGIPIAGQRAVVVGRSDIVGKPVAMLLLHEHATVTICHSKTPDLKSLCREADILVAAIGRAAMITGEFIKPGATVIDVGTNHVADREKAARIYRNSPEKMANFDKRGNLLIGDVDPVGVVEKAGAYTPVPGGVGPLTIAMLMVNTVASAERRAGVC
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: STE7_SCHPO
Sequence: MFLEIILDSATYSFDRVITGKICFETNAATSPRSFQIQLRIKGYAVYHHGFLSSPSHKHPTTASASDSDEATEIFTHSQPLPIPAGPSSKSHAIDFKFKFPSKSASSLPCSKSNDSMVNICYMLKATISKRYAFLGSSQSAKAELIMVPPNLAGKPLSANSSFGSSAKTFQLPEFDSVTPSASLYKQPSFNSNPAPITTSSATHTSQFSTSSSSSVNSVHTPVMVPNPYFQYNSSMTAPSSSSSSVAPFVPRRQFSVSSASDPPQTPISMSPPIPPTPSQFSAFMYQNQQSYLSPQSHYENPLSISSRPSPCCPSTPSSAVTLSNGFDSQSNAYNNSGTGPPMLYKFPQRSYTAPNTSFNSQRRMSSITSLPTASFCPVKHGVSPPSLAGNQPSPLSSPLTNSNVSPSTICSPDNNVTFVNLAPGEKLTFKIEPNDLMDEEEVVENSNMYSIPGKTVATTVCHSSSSSGDFSALSCHRNLSFSESLPTAEDQVHNNHCAVSPSRRSSSNALYLATLPMGYERSNSVSYCSDSSLSSPLPDDNMLQDPHALNMAYAKEFDVLINEVLQSL
What is the function of this protein?
Has a role in promoting meiosis whereby it is involved in establishing the mating pheromone signaling pathway.  It also has a role in suppressing meiosis until the conjugation process is complete.
What are the official names of this protein?
Protein ste7.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: RS17E_METM5
Sequence: MGRIRQTFIKRTGEELIEKFADKFTSDFEENKKAVEEVAMISTKTLRNRVAGYVTAKVKKMNA
What are the official names of this protein?
30S ribosomal protein S17e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: MCR1_ASPNC
Sequence: MFARQAFRCAQPLKQGFRKYSTEAPKGKSSLAPIYAAVGITGVGVGLYRYNSATAEAPAAVDRPKVFKGGDQGWFDLKLSEIEVLNHNTKRLRFEFEDKEALSGLQVASALLTKFKPADAKAVIRPYTPTSDEETPGYIDLVVKVYPNGPMSEHLHSMNVGQRLDFKGPIVKYPWETNKHNHICLIAGGTGITPMYQLAREIFKNPEDQTKVTLVFGNVKEEDILLKKEFEELENTYPRRFRAFYVLDNPPKEWTGGKGYISKELLKTVLPEPKEENIKIFVCGPPGMYKAISGTKNSPTDQGELSGILKELGYSKEQVFKF
What is the function of this protein?
May mediate the reduction of outer membrane cytochrome b5.
What are the official names of this protein?
NADH-cytochrome b5 reductase 2, Mitochondrial cytochrome b reductase.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: TMTC3_MOUSE
Sequence: MLEGKMADINFKEVTLIVSVVAACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNTVFHAVVSVIFLKVCRLFLDKRSSMIAALLFAVHPIHTEAVTGVVGRAELLSSVFFLAAFLSYTKSKGPDNSIVWTPIVLTVFLVAVATLCKEQGITVVGICCVYEVFVAQGYTLPMLCTVAGQFLRGKGSIPLSMLQTLVKLIVLMLSTLLLVVVRVQVIQSQLPVFTRFDNPAAVSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESFLDVRNLATFAFFCFLGALGIFSLRYPGDSSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISNKSVLKKLSWVCLSMVILTHALKTLHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFEKALKYFLQATHVQPDDIGAHMNVGRTYKNLNRSREAEASYMLAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVYIELKEPNEALKNFNRALELNPKHKLALFNSAILMQESGEVKLRPEARKRLLNYVNEEPQDANGYFNLGMLAMDDKKDSEAESWMKKAIKLQPDFRSALFNLALLYSQTAKELKALPILEELLKYYPDHTKGLILKGDILMNQKKDIPGAKKCFEKILEMDPSNVQGKHNLCVVYFEEKELLKAERCLVETLALAPHEEYIQRHLSIVRDRISSSGIVEQPLAPADKTPGTEEREEIPSEDVKEISSESRPPQILKTNNNRNSKSNKQSTENADQDAPHKTTKDIKEIEKKRVAALKRLEEIERILNGE
What is the function of this protein?
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.  The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions.  Also acts as O-mannosyl-transferase on other proteins such as PDIA3.  Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.
What are the official names of this protein?
Protein O-mannosyl-transferase TMTC3, Transmembrane and TPR repeat-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the TMTC family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein: SSRP_STRS2
Sequence: MAKGEGNVIAQNKKARHDYTIVDTVEAGMVLTGTEIKSIRAGRINLKDGFAQIKQGEAWLVNVHIAPYDEGNIWNQEPTRTRKLLLRKKQIESLDNEVKGTGMTLVPLKVYIKDGFAKVLIGLAKGKHDYDKRESIKRREQDRDIKRTMKAINSR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.