PharMolix/UniProtQA huggingface dataset:
Protein: FABA_CAUVN
Sequence: MQKNAYTFEELLACGRGEMFGPGNAQLPAPPMLMFDRIVRIEAEGGKYGKGYVEAEFDIRPDLWFFDCHFIGDPVMPGCLGLDAMWQLVGFFLGWSGGPGRGRALGVGEVKFTGQVTPDIKKVVYKIDLKRVIMRKLVMGIADGVLEADGKVIYETSDLKVGLFTPEQMA
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_SERP5
Sequence: MARVTVQDAVEKIGNRFDLVLVAARRARQIQTGGKDALVPEENDKYTVIALREIEEGLITSQILDVRDRQEQQEQEAAEIQAVTAIAEGRR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: D19L3_PONAB
Sequence: MMSIRQRREIRATEVSEDFPAQEENVKLENKLPSGCTSRRLWKILSLTIGGTIALCIGLLTSVYPATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFYGLIYDNKTESMKTINLLQRMNIYQEVFLSILYRVLPVQKYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVKATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLGKLLLHLFMVLCLTLFLNNIIKKILNLKSDEHIFKFLKAKFGLGATRDFDANLYLREEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNLSDSTNQQSVGKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSPEIWELLLKSVHLYNPKRICIMRYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSSLRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHNPSLGTLVTATGAGQGRDDGWPRRERS
What is the function of this protein?
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
What are the official names of this protein?
Probable C-mannosyltransferase DPY19L3, Dpy-19-like protein 3, Protein dpy-19 homolog 3.
What is the protein family that this protein belongs to?
Belongs to the dpy-19 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AIMP1_CRIGR
Sequence: MCEVFRRLPGTAPGSSPPAPATHRLRLLGRELRVRRFMIFCRFWAKMATNDAVLKRLEQKGAEADQIIEYLKQQVALLKEKAVLQATLREEKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIPVPVQSDTPVQASSAVSTSVIQSTSVSTISCSIKEHSKGGGEEKKVKEKTDKKGEKKEKKLQSAAPSADSKPVDVSRLDLRIGRIVTVKKHPDADSLYVEEVDVGEAAPRTVISGLVNHVPLDQMQNRMVVLLCNLKPAKMRGILSQAMVMCASSPEKVEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNAECVATYKGSPFEVKGKGVCRAQTMANSGIK
What is the function of this protein?
Non-catalytic component of the multisynthase complex.  Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase.  Binds tRNA.  Possesses inflammatory cytokine activity.  Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.  Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels.  Promotes dermal fibroblast proliferation and wound repair.  Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum.  Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations.  Induces maturation of dendritic cells and monocyte cell adhesion.
What are the official names of this protein?
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Secreted. Endoplasmic reticulum. Golgi apparatus. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels. Secreted in response to hypoxia. Also secreted in response to both apoptotic and necrotic cell death.
Protein: APEA_THEMA
Sequence: MKMERKNVWHHRKKEEIEAFSKEYMEFMSKAKTERMTVKEIKRILDESGFVPLEDFAGDPMNMTVYAVNRGKAIAAFRVVDDLKRGLNLVVAHIDSPRLDFKPNPLIEDEQIALFKTHYYGGIKKYHWLSIPLEIHGVLFKNDGTEIEIHIGDKPEDPVFTIPDLLPHLDKEDAKISEKFKGENLMLIAGTIPLSGEEKEAVKTNVLKILNEMYGITEEDFVSGEIEVVPAFSPREVGMDRSLIGAYGQDDRICAYTALRALLSANPEKSIGVIFFDKEEIGSDGNTGAKARFYLKALRQILKMQGAKDSEFVLDEVLENTSVISGDVCAAVNPPYKDVHDLHNAPKLGYGVALVKYTGARGKYSTNDAHAEFVARVRKVLNEQGVIWQVATLGKVDQGGGGTIAKFFAERGSDVIDMGPALLGMHSPFEISSKADLFETYVAYRSLMEKL
What are the official names of this protein?
Probable M18 family aminopeptidase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M18 family.
Protein: ATPF_STRPQ
Sequence: MSITFGELVGNFILVTGSVIVLLLLIKKFAWGAIESILQTRSQQISRDIDQAEQSRLSAQQLEAKSQANLDASRSQASKIISDAKEIGQLQGDKLVAEATDEAKRLKEKALTDIEQSKSDAISAVKTEMSDLTVLLAKKIMGANLDKTAQSQLIDSYLDDLGEA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DAPB_NEIMB
Sequence: MTPLKIAIAGANGRMGRVLVEAVNNHPDTVLSGALEHSGSEALGLDAGYAVGLKTGIAISDDVDAVLAQSDVLIDFTRPEPTLKHLQKCVEKQVNIIIGTTGFDDTGKAAIHTAAEKTGIVFAANFSVGVNLTFHILDTVARVLNEGYDIEIIEGHHRHKVDAPSGTALRMGEVIAGALGRDLKQCAVYGREGHTGPRDPSTIGFATVRAGDIVGDHTALFATDGERVEITHKASSRMTFAAGAVRAAVWVNGKTGLYDMQDVLGLNNR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_PROM3
Sequence: MQCPSCQNTDSRVLESRAADAGRSVRRRRECLHCDFRFTTYERVETVPITVLKRNGNRETFNRSKILNGLTMACQKTGLEQDRLESMVNELELQLQQRSGREVNSAEIGEMVLDQLSEMSEVAYVRFASVYRHFRGINDFVAALEGIHANKEQLAAVR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: GPMI_PSET1
Sequence: MSEHKKPLVLMILDGWGYREDEQSNAILAANTPVLDELWATRPRTLISASGFDVGLPDGQMGNSEVGHVNLGAGRVVYQDFTRITKAINDGEFDSTPALVDNIDKAVSADKAVHIMGLLSPGGVHSHEDHIVASIELAAKRGAKEVYFHGFLDGRDTPPRSAKASIERIEAVFAKLQCGRLASLIGRYYAMDRDNRWNRVEKAYNLLTLAQGDFSYPTGVSALEAAYERDENDEFVAASTITPAGAEPVQINDGDTVIFANFRADRAREITRAFVEPNFDGFAKQKSPALSAFVMMTEYAADIDAPVAFGPTPLVNVLGEWFEKHGKTQLRISETEKYAHVTFFFSGGREDEFNGETRELIPSPQVATYDLQPEMNSEMLTDKLVAAIKSGKYDAIICNYPNGDMVGHSGVFAAAVKACEAVDHCIGRVVAALNKYGGEALITADHGNAEQMANLKTGQAHTAHTSEPVPFIYVGRDATASEGKALSDVAPTMLHLMGMEQPTEMTGKPIMTLK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: OTC_ECO24
Sequence: MSGFYHKHFLKLLDFTPAELNSLLQLAAKLKADKKSGKEEAKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKTFNEMTLVYAGDARNNMGNSMLEAAALTGLDLRLVAPKACWPEAALVTECRALAQQNGGDITLTEDVAKGVEGADFIYTDVWVSMGEAKEKWAERIALLRDYQVNSKMMQLTGNPEVKFLHCLPAFHDDQTTLGKKMAEEFGLHGGMEVTDEVFESAASIVFDQAENRMHTIKAVMVATLSKLNN
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DMS1_PHYTS
Sequence: GLWSKIKETGKEAAKAAGKAALNKIAEAV
What is the function of this protein?
Antimicrobial peptide, active against the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli and P. aeruginosa, and the yeasts C. albicans and P. brasiliensis.  Has hemolytic activity (40% hemolysis at 128 ug/ml).
What are the official names of this protein?
Dermaseptin-1, DStar 01.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMI_PYRAB
Sequence: MIREGDKVVLVDPRGKRYLITVSKRDFHTDLGILKLEEIIGRNFGEAIKSHKGHEFKILRPRIVDYLDKMKRGPQIVHPKDAALIVAYAGISPGDFIVEAGVGSGALTLFLANIVGPEGRVVSYEIREDFAKLAWENIKWAGFDDRVTIKLKDIYEGIEEENVDHVILDLPQPERVVEHAAKALKPGGFFVAYTPCSNQVMRLHEKLREFKDYFMKPRTINVLVFDQEVKKECMRPRTTALVHTGYITFARRI
What is the function of this protein?
Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenosine at position(s) 57 (m1A57) and 58 (m1A58) in the T-loop of some tRNAs.  Methylates the first adenine of an AA sequence.
What are the official names of this protein?
tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI, tRNA(m1A57/58)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Protein: ISPT_NEIMB
Sequence: MKSSTQAVLEHTAIPKHIAVIMDGNGRWAKKRFLPRIMGHKRGLDALENMVKHCAKLGVQYLTVFAFSTENWRRPEDEVSFLMGLFLQALQKQVRRLHENNMRLKILGSRERFNRQILQGIEEAEALTANNTGLTLSIAADYGGRWDILQAANKLIAEGVSEITEDTLAKHLMLGDAPEPDLFIRTGGETRISNFLLWQMAYAELYFTDILWPDFDGKALDDAVASFQKRERRFGRTSEQLPIEQQRN
What is the function of this protein?
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
What are the official names of this protein?
Isoprenyl transferase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: RS5_METPB
Sequence: MAREREGRRRDDREERDSEFVDKLVHINRVAKVVKGGRRFGFAALVVVGDQKGRVGFGHGKAREVPEAIRKATEAAKRGLIRVSLREGRTLHHDVNGRHGAGKVILRAAPQGTGIIAGGPMRAVFETLGMQDVVAKSLGSSNPYNLVRATFDALKNEDSPRSVAARRGLKVSALQARRRDADPADTSDAAVA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: BIOF_XANAC
Sequence: MARPDLHERISSLRKLRVAQERVRVRRQVGRRDGVRLEIDGRWLTGFCSNDYLGLSQQFEVVAALQDAAARDGAGATASHLICGHHTAHETLEREIAEWLGYPSALLFGSGFIANLAVQQALLSEEDDVCVQDRLNHASLLDATRLAGCRLRRYPHLDVEGAMRQLKGAPEGAAMLATDGVFSMDGDVAPLRALSLVARMQQALFYVDDAHGVGVLGPQGRGCVADAGLGVAEVPLQLVTLGKALGGYGAVVVGEEALVRHLAETARPYIYTTALPPAQVAATLAAVRLARRDDWRRARLVELIGAFRDGARKHGFELMASDTPIQPLLCGEEATVMAMSAALEHAGFMVGAIRPPTVPEGKARLRVTLSALHTQQQVQALIEAIVQARDVVSRQPLRASA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: RS7_UREPA
Sequence: MRKLKPQKRQVLADPVYNSRLVTKLINAIMYDGKKGLAQSIIYSAFEIVEQKTGKPALEVFNKAIDNVMPIIELKVRRVGGSNFQVPTEVTPERRQTLGLRWITLYARLRHEHTMIEKLAHEIIDASNNVGAAIKKKEDTHKMAEANKAFAHLRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: CPPED_PONAB
Sequence: MSAAEAGGVFHRARGRTLDAFPAEKESEWKGPFYFILGADPQFGLMKAWSTGDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRTEQTEDLKRVLRTVDRAIPLVLVSGNHDIGNAPTAETVDEFCRTWGDDYFSFWVGGVLFLVLNSQFYENPSKCPSLKQAQDQWLDEQLSIARQRHCQHAIIFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGRDPHGLRVVVVTAEKIVHRYYSLDELSEKGIEDDLMDLIKKK
What is the function of this protein?
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis.  May play an inhibitory role in glucose uptake by adipocytes (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase CPPED1, Calcineurin-like phosphoesterase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the metallophosphoesterase superfamily. CPPED1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_JANMA
Sequence: MNADLTVVSPQIQAQILAEALPYIRKFHGKTIVVKYGGNAMTEERLKHGFARDVILLKLVGMNPVVVHGGGPQIDNALKKIGKQGTFVQGMRITDEETMEVVEWVLGGEVQQDIVMLINHYGGQAVGLTGKDGGLIRAKKMQMPDKEHPGQFLDIGFVGDIEAINPAVVKALQDDAFIPIISPIGFGDDGQAYNINADVVAGKIAEILKAEKLIMMTNIAGVQDKQGNLLTDLSAREIDEMFEDGTISGGMLPKISSALDAAKSGVNTVHIIDGRIEHSLLLEVLTEQAFGTMIRSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUBR1_METJA
Sequence: MVELKIACKLDGSCEKPRYRKYKCKVCGWVYDPLKGDPSQNIPPKTPFEELPDTWICPVCRGKVGKESFEPLDEWVEFDE
What is the function of this protein?
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide.  Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity).
What are the official names of this protein?
Probable Rubredoxin-1, RD 1.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
Protein: RUVB1_ASPFU
Sequence: MVQISEVKGSSRENRTAAHTHIKGLGLRPDGTAEPSADGFVGQAAAREACGVVVDLIKAKKMAGRAIMLAGGPGTGKTALALAVSQELGTKVPFCPIVGSEIYSAEVKKTEALMENFRRAIGLRVRETKEVYEGEVTELTPEEAENPLGGYGRTISHLIIGLKSAKGTKKLRLDPSIYEAIQKERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPVPKGEVHKKKEIVQDVTLHDLDMANARPQGGQDVMSMMGQLMKPKKTEITDKLRQEINKVVNRYIDQGVAELVPGVLFIDEVHMLDIECFTYLNRALESSISPIVILASNRGHTVIRGTDDITAAHGIPPDLLARLLIIPTHPYTPDEIKTIIRLRAKTEGLNITDPALDKVADHGSKVSLRYALQLLTPASILARVNGRPGGIEEADIAECEDLFLDAKRSAAIVSQDSEKFLS
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair.  Also involved in pre-rRNA processing (By similarity).
What are the official names of this protein?
RuvB-like helicase 1.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YQVW_CAEEL
Sequence: MKRLWKKVGSGVKNANYLKKSVEEVAKIEKGETKVVPPKYPTEKSREVSEEIKKELAMKNESLVENMNKMYIKSTDPVERWTSTKDLPTRESEFLHRNDPIWEYGFYEPPVERIPKDKLMFKEALEYLRFRQELLSDSSSPAQKKQAAEFVADHVVTSRVNAETLDDIYEYFRPFERKDKQKVVNRHALAALQDHVQGNSDERRILDEAKDVGKKIRHISNNTKFLDEYQRLEDEEKDKVREAIAQLRQEEHERLNKRLGQLGEIEKTAQEAMKKAVEEKKEK
What are the official names of this protein?
Uncharacterized protein B0035.15.
Protein: NRDR_STRPI
Sequence: MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERVEERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENEIQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: URED_BURCH
Sequence: MSAPDSHAPLSRPAVAKSWRGRLELGFERHGARTTLAHRLHDGPLRVQRPLYPEGDAICHAVIVHPPGGVAGGDRLDIDIALGDGTHAVLTTPGATKWYKSNGLDATQRIGIAVGPHAKLDWLPQNNLFFDAAHAALDFTVTLGEGASAIGWDATQIGRQAAGETWAAGRIASTSALVAADGRPLWTERALLDARDPLRGALQGLAGFPAYGTLWAAGAACDAALAEALAARMPFDDTLRAAATCVTPGVVLVRAISTSMEALQRHFTDCWLRLRPIVHDVDARPLRLWQT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MECA_EXISA
Sequence: MKIERINDNTVKFFITYVDIEKRGFARDEIWYNRERGEQLFWQMMDEAHEREDISFDGPLWIQVQAFEKGLEVTVTIAKNVMDTEDDSELGSLLRSAIDEARDQQSVLDQLSELDELEAEADAWAPLAMETNDFEAIISLSKRTGDMFSDLDLKLYHYQDRYYLWIDFPDEMEPEDEENALSLLAEYLTFSTQTQPMLEEYGKLILDGDVFAKVRHYF
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: TIG_METC4
Sequence: MQVTETTSEGLKREFQVLLPANELEDRLNTELSNIKGKVQIKGFRPGKVPVAHLRKVYGKSVMADVLQNAVNEANQQIVTDKGLRLALEPQIEFPKDEEQTIIERALDAKGDLAFKVKLEVLPSFELADLSDVSIKKLVLKPSDEEVNETLERMAKDSRSFEPREEGAEAQSGDRVTIDFVGRIDGTEFEGGKGEDVDLELGSNTFIPGFEDQLVGAKVGDSRLVKVAFPADYQAEQLAGKDAEFDVTVKAVAAPGETKIDDELAKRFGMDDLEKLKEAVSKAVGSDYEAQSRRKLKKELLDALDGKYAFDLPPSLVHQEFAAVWAQVEQDLKTRGKTFEDEGTTEEASQAEYRKIAERRVRLGLVLAQVGETADIKVSDDEVNQALFARIRQFPGQEKQVYDFYRNNPQALAELRAPLFEEKVVDHVLGQVQVVEEPVSKEALFAEDDEADAVTGGAATDEKPSESNNEAAADKAAG
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ATPD_LEPIC
Sequence: MNDSGVSKTYASALLGATNVPEEVEQELGDLAQLLFKDEKVKNFFLSPTVSNEEKEKVLIKNLRGKISDITLNFLGVLLNRGRIIHLPEIQKQFTVELDKKKGRVRAQVRSYPSLEPAQAAKLGSILSEKFKSEFILEVSEDKSLLGGFVVQFNDLKIEKSIASQLGEIKKSMLEKKLPVGAIYEN
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PRIO_BUBBU
Sequence: MVKRHIGSWILVLFVVMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPSQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMHRYPNQVYYRPVDQYSNQNNFVHDCVNITVKEHTVTTTTKGENFTETDIKMMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISLLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: YCF3_ADICA
Sequence: MPRSQRNDNFIDKTFTILADILIRILPTTKREREAFIYYRDGMSAQSEGEYAEALGSYYKAMRLEIDSYDRSYILYNIGLIHTSNGNHAKALEYYFQALERNSFLPQAFNNMAVICHYRGEQAIYQGDLEISEAWFDQAAEYWRRAIALSPDNYAEAQNWLKITGRFSPSHRWESWNNSTRVA
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RPIA_SHEWM
Sequence: MTQDEMKKAAGWAALEYVEKDSIVGVGTGSTVNHFIDALATMKAEIEGAVSSSEASTQKMKDLGIPVFDLNSVDELSVYVDGADEINAHMDMIKGGGAALTREKIVAAVADKFICIVDNTKQVDVLGEFPLPVEVIPMARSYVARQLVKLGGDPVYREGVITDNGNIILDVYNMKIVNPKELEQQINKIVGVVTNGLFANRGADVLLVGSPDGVKTLK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.