PharMolix/UniProtQA huggingface dataset:
Protein: H4_URECA
Sequence: MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SYH_BRUSU
Sequence: MADKADKMKARLPRGFVDRVPDDLRAAEKMMATIREVYDLYGFEPVETPLVEYTDALGKFLPDQDRPNEGVFSFQDDDEQWLSLRYDLTAPLARYVAENFETLPKPYRSYRNGWVFRNEKPGPGRFRQFMQFDADTVGAPNVSADAEMCMMMADTLERLGIQRGDYAIRVNNRKVLDGVLDAIGLEGEGNAAKRLNVLRAIDKLDKFGPEGVRLLLGKGRLDESGDFTKGAQLPEAAIEKVLAFTAAGGADGAQTIANLQAVVAGNAEGEEGVQELADMQALFFAGGYEGRVKIDPSVVRGLEYYTGPVFEAELLFDVTNEDGQKVVFGSVGGGGRYDGLVSRFRGEPVPATGFSIGVSRLMTALKNLGKLDVSDTVGPVVVLVMDKDTQNLGRYQKMVSDLRKAGIRAEMYVGGSGMKAQMKYADRRAAPCVVIQGSQEREAGEVQIKDLVEGKRLSAEIEDNVTWRESRPAQITVREDGLVDAVREILDAQARDRAEQSK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGC_THEAB
Sequence: MKNVVALILAGGQGTRLGVLTEKIAKPAVQFGGKYRLIDFTLSNCVNSGIYKIGVLTQYKPHLLNQHIGIGKPWDLDRKDGGVTILQPYYTEKKGVWYNGTADAVYRNIEFVDDYNPEYVVILSGDHIYSMDYNELLDYHKAKSALATVACMEVPLSEASRFGIMVTDLENRIIEFQEKPKQPKSTLASLGIYVFQWSFIREVLIEDAKNDQSSHDFGKDIIPKIIQTERVFAFPFDGYWKDVGTIYSYWESNLELTRPIPPFNIHDENWRIYTHSKEMPPAYIADSTKVKNSLISEGCEIYGAVSNSVLAQGVEIGKGSIVKNSVIMSNVRIGENCYIENAIIAENVVIGDFVKIGVGEFAESKLNKKVYNSEITVIGMDSIIESKVEIGKNCVVGIDMIVNKNLNSGEYI
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: FMT_FRATW
Sequence: MKKLNIIFAGTPDISAQVLKDLYKSQHNIQAVLTQPDRAKGRGKKVQFSPVKEVALANHTPVFQPLSFKKNPEVLEQIKQLKPDVIVVIAYGIIVPQEFLDIPRYGCLNIHVSLLPKWRGAAPIQRAIQAGDTKTGVCIMQMDAGLDTGDILNTLEIEIQETDTSQTLHDKFAKLSIKPLLETLEKIEIIKPEPQQGEPTYAHKITKQEGLIDFTKSAWQISCHIRAFTPWPGAYFILDDEAIKVGEFEILYQNTDNRKAGTIIDIYRSGFDIATSDKIIRFRQLQFPNKKMLNIVDILNGKDLDKYIGYKLG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: CTHL3_CHICK
Sequence: MLSCWVLLLALLGGACALPAPLGYSQALAQAVDSYNQRPEVQNAFRLLSADPEPGPNVQLSSLHNLNFTIMETRCQARSGAQLDSCEFKEDGLVKDCAAPVVLQGGRAVLDVTCVDSMADPVRVKRFWPLVPVAINTVAAGINLYKAIRRK
What is the function of this protein?
May bind bacterial lipopolysaccharide (LPS).  May have antimicrobial activity and play a role in the innate immune response (By similarity).
What are the official names of this protein?
Cathelicidin-3, CATH-3, Fowlicidin-3.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted. Membrane; Single-pass membrane protein.
Protein: RRF_CORGL
Sequence: MIDEILFEAEERMTATVEHTREDLTTIRTGRANPAMFNGVMAEYYGVPTPITQMSGITVPEPRMLLIKPYEMSSMQVIENAIRNSDLGVNPTNDGQVLRVTIPQLTEERRKDMVKLAKGKGEDGKIAIRNIRRKGMDQLKKLQKDGDAGEDEVQAAEKELDKVTAGFVAQVDEVVARKEKELMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAL_THEAB
Sequence: MKIFLDTANLDEIRRGVEWGVVDGVTTNPTLISKEGKPFEETIKEICNIVQGPISAEVISLNFEGMIDEARNLAKIDENIVIKIPMTPNGIKAVKVLSKEGIKTNVTLIFSPNQALLAAKAGATYVSPFVGRVDDLANDGLKIVEEIMQIYENYGFETEVIVASVRHPMHVLEAALIGADIATVPFSVLEKMFKHPMTDIGIERFLKDWEKYKTGR
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STMN2_MOUSE
Sequence: MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
What is the function of this protein?
Regulator of microtubule stability.  When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons.  In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
What are the official names of this protein?
Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10.
What is the protein family that this protein belongs to?
Belongs to the stathmin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection, axon. Membrane; Peripheral membrane protein; Cytoplasmic side. Endosome. Golgi apparatus. Cell projection, lamellipodium. Note=Colocalized with CIB1 in neurites of developing hippocampal primary neurons. Colocalized with CIB1 in the cell body, neuritis, growth cones of neurons and in neurites of developing hippocampal primary neurons. Colocalized with CIB1 to the leading edge of lamellipodia (By similarity). Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Exists in both soluble and membrane-bound forms. In the developing brain, mostly cytosolic.
Protein: TRMA_VIBCM
Sequence: MATLDVNPELYQAQLADKIARLKAMFVDYSMPELEVFESPVANYRMRAEFRIWHEGDDMYYIMFNQETREKYRVDQFPAASRLINDLMPLLMDAMKGSPILRHKLFQVDFLSTLSGEILVSLLYHRQLSEEWITAAQALKQRLNDEGFNLNLIGRARKMKVVLDRDYVVENLQVNGQPYVYKQVENSFTQPNAKVAEKMLEWAVDCTQESKGDLLELYCGNGNFSLALAQNFERVLATELAKPSVEAAQFNIAANQIGNVQIIRMSAEEFTQAMEGKREFNRLKDAGVDLQSYRCNTIFVDPPRSGMDIDTCKMVQGYERILYISCNPETLQENLQVLGETHQVVRFALFDQFPYTHHMEAGVMLERKK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: SYK_POLNS
Sequence: MNDKSNLPPVTEAIDENHIIAERREKLAKLRKGGVAFPNDFAPTHLAADLHSYYDSLTKKELAAKKIHVKVAGRMVLKRVMGKTSFATIQDRSGQIQFYINDELSGADVHGAFKHWDMGDFISTEGNLFKTNKGELSVECSNLRLLSKSLRPLPDKFHGLSDLETKYRQRYVDLIVNPESRSTFKARSNAIASLRRHMLDADFMEVETPMLHPIPGGAAAKPFITHHNALDMQMFLRIAPELYLKRLVVGGFERVFEINHNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDFTEGLIRAAAIDAQGTAVLTHQGRELDLSKPFQRLTITEAILKYCGQSGKSYEAAQLEDANFIRVELKKGGENPDAPTLKNAGIGALQLALFELVAEEHLWEPTYIIDYPIEVSPLARESDTRPGITERFELFITGREIANGFSELNDAEDQANRFRKQVEQKEAGDEEAMYFDHDFIRALEYGMPPTGGCGIGIDRLIMLLTDAPNIRDVILFPHLRREED
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FENR2_LISMO
Sequence: MDEKTKIYDITIIGGGPVGLFAAFYAGMRNASVKIIESLPQLGGQLSTLYPEKYIYDIPGYPSVRAQELVNNLIQQMKPFDPTVALEEAVQSVEKQVDGTFEIITKKDTHYSKAIIITAGNGAFEPRRLDLPEAEQYEGTNIHYFINDLSRFSGRRVAVCGGGDSAVDWALMLEKVASSVAIVHRRNAFRAHEHSVNNLEKSSIAIKTPFIPTEVLGNGDKLTHITLQEVKGDTTETLEIDDFIINYGFVSSLGPIKNWGLELERNSIVVNSKMETSIPGIYCAGDICTYDGKVKLIATGFGEAPTAVNNAMNFIDPKTRVQPMHSTSLFE
What are the official names of this protein?
Ferredoxin--NADP reductase 2, FNR 2, Fd-NADP(+) reductase 2.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: PMTQ_ARATH
Sequence: MAQPRYTRIDNRRPSSNYCSTVTVVVFVALCLVGIWMMTSSSVGPAQNVDEVSLDNKDGIKKQMTPPAEEGNGQKFEDAPVETPNEDKKGDGDASLPKEDESSSKQDNQEEKKEEKTKEEFTPSSETKSETEGGEDQKDDSKSENGGGGDLDEKKDLKDNSDEENPDTNEKQTKPETEDNELGEDGENQKQFESDNGEKKSIDDDKKSSDDDKENKTGNEDTETKTEKENTETNVDVQVEQEGQSKNETSGDLSPPGAQLELLNETTAQNGSFSTQATESKNEKEAQKGSGDKLDYKWALCNTTAGPDYIPCLDNVQAIRSLPSTKHYEHRERHCPDSPPTCLVPLPDGYKRPIEWPKSREKIWYTNVPHTKLAEYKGHQNWVKVTGEYLTFPGGGTQFKHGALHYIDFIQESVPAIAWGKRSRVVLDVGCGVASFGGFLFDRDVITMSLAPKDEHEAQVQFALERGIPAISAVMGTTRLPFPGRVFDIVHCARCRVPWHIEGGKLLLELNRVLRPGGFFVWSATPVYQKKTEDVEIWKAMSELIKKMCWELVSINKDTINGVGVATYRKPTSNECYKNRSEPVPPICADSDDPNASWKVPLQACMHTAPEDKTQRGSQWPEQWPARLEKAPFWLSSSQTGVYGKAAPEDFSADYEHWKRVVTKSYLNGLGINWASVRNVMDMRAVYGGFAAALRDLKVWVMNVVPIDSPDTLAIIYERGLFGIYHDWCESFSTYPRSYDLLHADHLFSKLKQRCNLTAVIAEVDRVLRPEGKLIVRDDAETIQQVEGMVKAMKWEVRMTYSKEKEGLLSVQKSIWRPSEVETLTYAIG
What are the official names of this protein?
Probable methyltransferase PMT26.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: PYRDB_LACLA
Sequence: MTENNRLSVKLPGLDLKNPIIPASGCFGFGEEYAKYYDLNKLGSIMVKATTLHPRFGNPTPRVAETASGMLNAIGLQNPGLEVIMAEKLPWLNENFPDLPIIANVAGSEEDDYVAVCAKIGDAPNVKVIELNISCPNVKHGGQAFGTDPDVAAALVKACKAVSKVPLYVKLSPNVTDIVPIAKAVEAAGADGLTMINTLMGVRFDLKTRKPVLANITGGLSGPAIKPVALKLIHQVAQVVDIPIIGMGGVESAQDVLEMYMAGASAVAVGTANFADPFVCPKIIEKLPEVMDQYGIDSLENLIQEVKNSKK
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRDB_THEYD
Sequence: MPVLEVKIGNLSFKNPVLTASGTFGYGLEYSQFVDLNILGGIVVKGLSLKPKQGNPPPRIYETPCGMINSIGLQNIGLEAFKKEKLPFLKKFNTNIIVNFFGENLDEYIEVAKLLDETEGVHALEMNVSCPNKTSEWRKMGLEPELLREAIKRVRLHIKKPLIVKLAPQVTEIALMARICEEEGADAVSLINTIPAMVIDIKTRKSMIGTLTGGLSGPAIRPVALRAVWEVAQAVKIPVIGVGGIVSAEDALQFLIAGAKAIQVGTANFINPIATVEIIEGIKQFLIEENIKDINEIIGSFKE
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMT_MYCSE
Sequence: MTALDTDTPTAGRSAPLISPGPVIPPPDFGPLDRAQGWAMTAIITALAAITRFLNLGSPTDAGTPIFDEKHYAPQAWQVLHNDGVEDNPGYGLVVHPPVGKQLIAIGEWLFGYNGLGWRFSGAVCGVIIVMLVTRIARRISRSTLVGAIAGLLIIADGVSFVSSRTALLDVFLVMFAVAAFACLMVDRDQVRERMYHAFLDGRIAETRWGPRLGVRWWRFGAGVLLGLACATKWSGLYFVLFFGVMTLVFDAIARKQYHVPHPWRGMLRRDLGPAAYVFGLIPFAVYLASYAPWFASETAVNRYEVGRSIGPDSILPIPDALRSLWHYTHAAYRFHSNLTNADGNHHPWESKPWTWPMSLRPVLYAIDNQDVPGCGAQSCVKAVMLVGTPAMWFIAVPVLGWALWRTVVRRDWRYGAVLVGYMAGFLPWFADIDRQMYFFYATVMAPFLVLAIALILGDILYKPNQNPERRTLGLLTVCFYVALVITNFAWMYPILTGLPISQTTWNLQIWLPSWR
What is the function of this protein?
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins (By similarity).  Involved in DNA conjugation, in at least the recipient strain (PubMed:18554329).
What are the official names of this protein?
Probable dolichyl-phosphate-mannose--protein mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 39 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: STR6L_MOUSE
Sequence: MLAASTRTRQINITCDNPVDREVFLHYSLIPSLCIILVLSFLQRREHRRQRDDTSYLLGNHFGIIVPLDFVGTFSNRWSYGAAFGATANKVMFLFSEGYQPLTVPQWAQAFVLFIGGMEVGLSYFPFFACLSSEFQLVSSILGFSYSLTWFVVTVLQISQCPHGQFLGRFETLVFYWPSLLCLGFLLGRFLHMFLKALPVHLGLEPQTEEKSMLEAHQAKHVKQLLSKPRPQEGEKSWFQTRVYEWDPCFQFPSRMVGTLLLAFICLYLFIVIEFCVFLHVRDKLDMFEDKLESYLTHMNETGTLTPIILQVKELISVTKGVWVVTILPAALTCVTYLFHILACYRKHMKRLWAGDKHFLPQKFHSPSSAASVVAIARYSGWQIAYILWGYLIIHVVQSLCGVMLMYGLVLPIIHHRGLEMLQGFGLGVLTLSIVVGLIILQVWIAGTFFLQPKLGTSDKQKPLALNNRRAFHNFNYFLFFYNVLLGLGACLSRLLISCLLGTWLIARIDRTIMQSGYEGADMGFGAWIGMLFVDHYHTNPVLVSFCHILITSHKDRKLQKTVKYWCLNQSAGPRFSARARTRWFLLQTLINNPRLVMLRKSKSGHSSGEFTQILLTCSDC
What is the function of this protein?
Acts as a high-affinity cell-surface receptor for retinol-binding protein RBP4 and mediates RBP4-dependent retinol uptake in the liver.
What are the official names of this protein?
Stimulated by retinoic acid gene 6 protein-like, STRA6-like protein, Retinol-binding protein 4 receptor 2, RBP4 receptor 2.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYM_MARMM
Sequence: MARILITSALPYINGVKHLGNLAGSMLPADVYARFQRLRGHDVLYVCATDEHGTPAELAADAAGMDVRAYCDEQHDIQKRSGEGFSLSYDYFGRTSNAPNIRLTQHFAQVLEEKGLIAERVEEQVFSIDDDRFLPDRYVEGTCPHCGFERARGDQCDNCGRLLEPTDLKEPYSKISGSKNLEVRETKHLHLVQTQMETKIRDWVDASTEWPSLAKSIAYKWLDEGLRDRSITRDLKWGVPVAQDGTPREGFEGKVFYVWFDAPIGYIGATVEWAEAGGGDWESWWRTDKGADDVTYVQFMGKDNVAFHTVSFPATILGSEEPWKTVDKLKAFNWLTWYGGKFSTSEKRGVFMDQALDILPGDYWRWYLTANAPEGSDAAFTWEHFQGLINSDLANVLGNFVNRITKYTVSKFDGTLPSAGTPGENEAWMAAELDQRLPALVANMEAMEFRKAAAEVRAIWAAGNEYLTKAEPWVKYKSDVDAAAVGVRTGLNLVALFGILAQPFIPEAASKILDALGVPDDRRSWEFDGPASALLDALPHGMAITPPAVLFAKIEDAQVAEWTERFGGAPEA
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_PECCP
Sequence: MPHLAELVAKARTAIEEAQDVAALENVRVEYLGKKGHLTLQMTSLRELPAEERPAAGAVINQAKQDVQDALNARKHTLESAELNARLAQETIDVSLPGRTIENGGLHPVTRTIDRIETFFGELGFSVVTGPEIEDDYHNFDALNIPGHHPARADHDTFWFDATRLLRTQTSGVQIRTMEKQQPPIRIIAPGRVYRNDYDQTHTPMFHQMEGLIVDKDISFTNLKGTLHDFLRNFFEEDLQVRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGIDPEVYSGFAFGMGMERLTMLRYGVTDLRAFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WNK4_RAT
Sequence: MLAPRNTETGVHMSQTEADLALRPSPSLTSMGPTRLGPPPRRVRRFSGKAEPRPRSSRPSRRSSVDLGLLSSWSQPASLLPEPPDPPDSAGPMRSPPSNSKEHPEGTWTGAAPVKAADSACPELTVSSGGPGSREPPRVPDAAARERRREQEEKEDTETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERFTIQDLLTHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEVLPPDSGPPPATVSMTPGPPSAFPPEPEEPEADQHQSFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQPPGGMPSSPAEPHLCLPSGFALSIPRSGPGSDFSPGDSYASDAASGLSDMGEGGQMRKNPVKTLRRRPRSRLRVTSVSDQSDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLSRIREIIQRVETLLKRDAGPSEATEDALSPQEEPAAMPALPGPSDAELQRSISPEQRSWAAFSTSPSSPGTPLSPGTPFSPGTPPVFPCPIFPITSPSCHPYPFSQVSSNPCPQAPSSLLPSSSGASQVPFPSPSLPTSSPLPFSPSYPQVPLHPASLPTCPSPPPLPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPGPLPSMPLPLASCDQESLSAQTAETENEASRNPAQPLLGDARLAPISEEGKPQLVGRFQVTSSKEPAEPPLQPASPTLSRSLKLPTPQLTSESSDTEDSAAGGPETREALAESDRAAEGLGVAIDEEKDEGKEPQIGGSSPILSQPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQNLRQKHLSEVEALQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSCRQRRLSKGSFPTSRRNSLQRSDLPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRM
What is the function of this protein?
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation.  Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively.  Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6.  Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3.  Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis.  WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis.  Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.  Phosphorylates NEDD4L (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase WNK4, Protein kinase lysine-deficient 4, Protein kinase with no lysine 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
What are the subcellular locations of this protein?
Cell junction, tight junction. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex.
Protein: RL3_THEVB
Sequence: MTVGILGTKLGMTQIFDEAGRSVPITVVQAGPCPITQIKTPQTDGYTAIQVAYGEVREKNLSRPERGHLNKSQTPPMRHLREFRLEDVSAYQLGQAITVDIFSPGQLVDVRGTSIGRGFAGYQKRHNFKRGPMAHGSKNHRLPGSTGAGTTPGRVFPGKRMAGRMGNTAVTIRKLQVMRVDPERNLILIKGALPGKPGALVSITPAKVVGRK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PYRB_GEOTN
Sequence: MAHLLTLSELSLSEINRLLDEAETFRNGRPWHPATPMYVANLFFEPSTRTKCSFEMAERKLGLHVIPFDPERSSVQKGETLYDTVKTLEAIGVDAVVIRHHEDAYFEALRHSVGVSIINAGDGCGHHPTQSLLDLLTIRQEFGTFAGLTVVIIGDIRHSRVARSNAEVLTRLGANVLFSGPPEWEDDMNLHGTYVEIDEAIARADVVMLLRIQHERHAEKMGLTKEEYHQQYGLTLERAQLMKPGAIILHPAPVNRGVEIASQLVEAKPSRIFKQMENGVYVRMAVLKRAIEGRMQHGHVVEKWHVVQ
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: TARM1_MOUSE
Sequence: MISRLLSLLCLRLCVGQTDIPENGSPPKPSLSAWPSTVLPTKSHVTMQCKSPTPSKYFILKKEGFALNSVKPYNLTEETADFHFTDLRQNDGGHYTCEYYSKWPHDTPSHPSNALFLLVTGYLPQPSFQAHHRGTVTAGSKVTLQCQKAGSVLGPVKFALLKVGHSTPVQTRSSTGMVSDFSLQNVTARDSGEYSCVYYQAKAPYRASGPSNLLEISVIDNHLPQDLAASTFPPQLTATSPKTPGTMTEGYTVDNLIRVGVAAAILLIVGGFLVEAWHSERLSPNKPW
What is the function of this protein?
May act as receptor.  Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface.  Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils.
What are the official names of this protein?
T-cell-interacting, activating receptor on myeloid cells protein 1, OSCAR-like transcript-2 protein, OLT-2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: UPP_PYRAR
Sequence: MPVRIIDHVYAQYLLTRLRDKNTGSLDFRKGLVRLGRIIGYELVKTFPFRYVEVETPLGRAVGVDIIGLDKVVIVQILRAAMPLVEGLVKAFPNARLGVVAARRKEEEGYVDVEVFYSKMPSIGVEDTVIVADPMLATGTTMSKAIEEVYKTGTPGRLVVVSVIATPVGISRVLSRWPDTEIYTVAIDPELNDKAFIVPGLGDAGDRAFAT
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: ISPG_NEIG2
Sequence: MNTLQRRKTHQVLIDHITVGSEAPVVIQSMTNTDTADAKATALQIKELSDAGSEMVRITVNSPEAASKVAEIRRRLDDMGYATPLIGDFHFNGERLLAEFPECGKALSKYRINPGNVGKGVKGDEKFAFMIRTAAENDKAVRIGVNWGSLDQSLAKRMMDANLVSSAPKPPEEVMKEALIVSALESAEKAVLLGLPEDKIILSCKVSAVHDLIQVYRELGSRCVYPLHLGLTEAGMGSKGIVASTAALSVLLQEGIGDTIRISLTPEPGSPRTQEVVVGQEILQTMGLRSFTPMVTACPGCGRTTSTVFQELAQDVQNYLRQKMSIWRTLYPGVESLNVAVMGCVVNGPGESKLADIGISLPGTGETPVAPVYVDGERKVTLKGNNIASEFLAIVEEYVKTNYGKNSSKRNKGKVIPIQSL
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: NAGB_RHOBA
Sequence: MGGINVIEIEIVPDHESASARVAGFIVEQIRRKPASVLGLATGGTPERTYELLVEKVNAGHLSFSQATTFNLDEYVGLLPDHPQSYHAYMRFRLFGETDFDAERTHLPKGTADELSDAGGQYEALIAEAGGIDLQLLGLGANGHIGFNEPGATEDSRTRVVDLTEETIAANARFFDSPEDVPRRALTMGIATILEAREIVLIATGESKAEAVERSVRGPVAPQMPASFLQQHPSVTFVLDEAAASLLDKRA
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: PRMA_CHLSY
Sequence: MQTTSWLEIAVEVDPEAVETVSEILARYGYNGGVVVEQSWIAGDEGPEFQYDPNRPVWLRTYLPLDAQAEETRQQIEHALWHVHQIRPLGPIQTRTLAEEDWANAWKQFYPVLRVGERTVIVPSWLEYQPQPNDVVLLLDPGMAFGTGLHPTTRLCLHLLERLVQPGQQVLDLGTGSGILAIAAAKLGAGQVLALDNDPIAVRVAHENVERNQVQDLVTVAEGSLGAGQAMGHWLSGDFGPETPDPTLHDNTPQATFDLIAANLIAKVLVLLAPDLATALKPGGLLISSGIIDVKEAEVVAAFAAVGLQQIERHVEGEWVALVHRRPQ
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.