PharMolix/UniProtQA huggingface dataset:
Protein: OPTN_MACFA
Sequence: MSHQPLSCLTEKGDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFETQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTGDSRLPRAEAEQEKDQLRTQVTRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSIGTSRSAEGAKNYLEHEELTVSQLLLCLREGNQKVERLEIALKEAKERVSDFEKKASNRSEIETQTEGSTEKENEEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLAMLQLTHNKLLQEHNHALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDPDQQAYLVQRGTEDRDWQQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
What is the function of this protein?
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8.  Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation.  Negatively regulates the induction of IFNB in response to RNA virus infection.  Plays a neuroprotective role in the eye and optic nerve.  Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death.  May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD).  Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment.  Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
What are the official names of this protein?
Optineurin.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans- Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy.
Protein: OR7G1_HUMAN
Sequence: MGPRNQTAVSEFLLMKVTEDPELKLIPFSLFLSMYLVTILGNLLILLAVISDSHLHTPMYFLLFNLSFTDICLTTTTVPKILVNIQAQNQSITYTGCLTQICLVLVFAGLESCFLAVMAYDRYVAICHPLRYTVLMNVHFWGLLILLSMFMSTMDALVQSLMVLQLSFCKNVEIPLFFCEVVQVIKLACSDTLINNILIYFASSVFGAIPLSGIIFSYSQIVTSVLRMPSARGKYKAFSTCGCHLSVFSLFYGTAFGVYISSAVAESSRITAVASVMYTVVPQMMNPFIYSLRNKEMKKALRKLIGRLFPF
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 7G1, Olfactory receptor 19-15, OR19-15, Olfactory receptor OR19-8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: S2538_ASPNC
Sequence: MSNNAVYAVPQVKTTKTSSKTTFHFTAGLFSGLTSSILLQPADLLKTRVQQSQNASLLPTVKAILSSPNPIRNLWRGTLPSALRTGFGSALYFTSLNALRTGLVQTNGIAPVTNSSSALPKLSNTANLATGAAARVAAGFVMMPVTVIKVRYESDYYAYRSLFGAGRDIVRTEGFRGLFSGFGATAARDAPYAGLYVLFYEQLKRRLAGLSSSSSDQQPLKSSSINFVSGGLAAGLATTITNPFDAVKTRLQLMPGRYGNMMRAVRLMVQEDGVRSLFGGLGLRITRKALSSALAWTVYEELILRAEVQWGSKGE
What is the function of this protein?
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix.  Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL4_ACIB3
Sequence: MNLKTVSGSAVELSEVAFGREFNEALVHQVVTAYLAGGRQGTRAHKSRADVSGGGKKPFRQKGTGRARAGSIRSPIWVGGGKTFAARPQDWSQKVNRKMYRGAMQCILAELVRQDRLVLVEEFAVAAPKTKELLAKLNDLNAARALIVTDAVDENLYLAARNLPHVDVVDATAIDPVSLIAFDKVVMSVAAAKKIEVELG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PG197_VACCW
Sequence: MDTDVTNVEDIINEIDREKEEILKNVEIENNKNINKNHPSGYIREALVINTSSNSDSIDKEVIECICHDVGI
What are the official names of this protein?
Protein OPG197.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG197 family.
Protein: PXPA_VIBVY
Sequence: MNKQRVTLNCDMGESFGNWKMGSDELVMPWVDMANIACGFHASDPSVMSKTVALAKHYKVKIGAHPGYQDLVGFGRRSIPHTPAQISEIVLYQVGALKAVCQYHDVPLHYVKPHGALYNDMMESEAIFRAICEAVSIFGIPLMILATSDNQRYLDIADIYDVPLLFEAFADRQYQEDGKLTPRSQANAVYHQPEDIYNQALQIATYGSVNTANGTRLSLEADTICVHGDNPESITLVQRISQAIAKM
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: Y1601_HAEIN
Sequence: MKKLATLTALAGALTMAVATAAQAESKSSSTDNTATPCVGDKCVKTKAAEGKCGEGKCGADKAKSAEGKCGEGKCGADKAKSAEGKCGEGKCGSK
What are the official names of this protein?
Uncharacterized protein HI_1601.
Protein: SECA_BRUO2
Sequence: MVSFGGLARKIFGSSNDRRVKTLRQRAEQITALEKNYENLTDEQLQAKTAEFRAALAEGKSLDSLLPDAFATAREAAKRVLGMRPFDVQLIGGMVLHERGIAEMRTGEGKTLMATLPVYLNALEGKGVHVVTVNDYLATRDAETMGRLYNFLGLTVGVIKHGLDDDERRAAYACDITYGTNNELGFDYLRDNMKYERAQMVQRPHNYAIVDEVDSILIDEARTPLIISGPLEDRSDFYNLIDTFIPPLAEEDYEVDEKQKTAIFTEVGTEKVEKLLEAAGHLKGESLYDIENVAVVHHLNNALRAHKLFQRDKDYIVRNDEIVIIDEFTGRMMPGRRYSEGLHQALEAKEHVTIQPENQTLASITFQNYFRMYNKLSGMTGTAATEAEEFGNIYGLEVLEIPTNLPVQRIDEDDEVYRTVEEKYRAIVRDIRASHEKGQPILVGTTSIEKSEQLAERLRREGIKGFQVLNARYHEQEAYIIAQAGVPGAVTIATNMAGRGTDIQLGGNLEMRVRQELSDVPEGPEREEKIAAIKADIAQLKEKALAAGGLYVLATERHESRRIDNQLRGRSGRQGDPGRSKFFLSLQDDLMRIFGSDRMDGMLQKLGLKEDEAIVHPWINKALEKAQKKVEARNFEIRKNLLKYDDVMNDQRKVIFEQRLEMMDEEDLTETVAEMRHEVIEDMVILRIPKDAYAEKWDIAGLKQDIASKLNLDLPVEEWAKEEGIAEEEFENRIKEAADKAAAEKAERFGPQIMTYVEKSVIMQSLDNLWREHLVNLDHLRSVVGFRGYAQRDPLNEYKTEAFELFQTMLANLREVVISQLMRVEIVREAPPEPQLPPMAGLHIDGTTGENDFDEAIWAEHQHDDRIVPPAQRDPADPRTWGKVSRNEPCPCGSGKKYKHCHGAFE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: REXA_BP434
Sequence: MKNGFYATYRSKNKGKDKRSINLSVFLNSLLADNHHLQVGSNYLYIHKIDGKTFLFTKTNDKSLVQKINRSKASVEDIKNSLADDESLGFPSFLFVEGDTIGFARTVFGPTTSDLTDFLIGKGMSLSSGERVQIEPLMRGTTKDDVMHMHFIGRTTVKVEAKLPVFGDILKVLGATDIEGELFDSLDIVIKPKFKRDIKKVAKDIIFNPSPQFSDISLRAKDEAGDILTEHYLSEKGHLSAPLNKVTNAEIAEEMAYCYARMKSDILECFKRQVGKVKD
What is the function of this protein?
Inhibits the growth of unrelated coliphages, including T4rII, T5lr, T1, and some mutants of T7, P22, phi-80, and lambda.  It controls the activity of gene S and may inhibit the establishment of lysogeny by the repressor protein (By similarity).
What are the official names of this protein?
Protein rexA.
Protein: NIPA4_HUMAN
Sequence: MELRVSNTSCENGSLLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSPEEKPKVFIIHS
What is the function of this protein?
Acts as a Mg(2+) transporter.  Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).  May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway.
What are the official names of this protein?
Magnesium transporter NIPA4, Ichthyin, NIPA-like protein 4, Non-imprinted in Prader-Willi/Angelman syndrome region protein 4.
What is the protein family that this protein belongs to?
Belongs to the NIPA family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: JAZ13_ARATH
Sequence: MKGCSLDLHLSPMASTLQSCHQDSTVNDRSSTIRSKEINAFYSGRLSEYDLVEIQMRAIIEMASKDREVTALELVPVRLESPLGCSVKRSVKRFLEKRKKRSKSFTLTPNYTSSTSSSSSSLHNF
What is the function of this protein?
Non-TIFY functional repressor of jasmonate (JA)-mediated growth and defense responses.  Intrinsically resistant to JA-induced turnover, probably due to the absence of the canonical degron that strongly interacts with COI1 in the presence of JA-Ile in the TIFY/JAZ proteins.
What are the official names of this protein?
Protein JAZ13, Jasmonate ZIM domain-containing protein 13.
Protein: ACTP_ERWT9
Sequence: MSKNYLLAVLALLLSGPVVAADAIAGTVERQPVNMEAIVMFLIFVAMTLGITYWASRRTRSRSDYYTAGGNITGFQNGLAMAGDFMSAASFLGISALVYTSGFDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQMPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLDYHVAVVLVGILMVMYVLFGGMLATTWVQIIKAVLLLFGASFMAIMVMKNVGFSFDTLFSEAMKIHPKGVAIMRPGGLVNDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGLMGYFYFLTFIIGFGAILLVGANPAFKDATGALLGGNNMAAVHLADAVGGSLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVVRKGQASEREELRVSKITVVALGVVAILLGILFEKQNIAFMVGLAFSIAASCNFPIILLSMYWSRLTTRGAMTGGWLGLLTAVILMILGPTIWVQVLGHARPIFPYEYPALFSMLVAFIGTWLFSVTDNSTQGAEERLRFRAQFVRSQTGVGIEGGKGH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVB_PROMH
Sequence: MIEADRLISADIQQPEEEIIDRAIRPKLLAEYVGQPQVREQMEIFIQAAKLRHDALDHLLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLVGATTRAGSLTSPLRDRFGIVQRLEFYNVDDLQHIVARSASFMGLEITAEGARQIAMRSRGTPRITNRLLRRVRDFAQVKGNGEIDEDIASKALDMLNVDAAGFDYLDRKLLFAIIDKFMGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFIQRTPRGRVATNHAYRHFNRIMEAP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: COAE_BACFR
Sequence: MAIKIGITGGIGSGKSVVSHLLEVMGVPVYISDEESKKVVATDPVIRKELCDLVGEEVFSGGKLNKTLLATYLFASSTHASQVNGIIHPRVKEHFRQWSSHKECLDIIGMESAILIESGFADEVDCIVMVYAPLELRVERAVRRDNASCEQIMQRIRSQMSDEEKCERASFVIINDGEKPLIPQILELIAFLYQKIHYLCSAKNN
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_PSEF5
Sequence: MTDYKATLNLPDTAFPMKAGLPQREPQILQRWDSIGLYGKLREIGKDRPKFVLHDGPPYANGSIHIGHAVNKILKDMIIRSKTLAGFDAPYVPGWDCHGLPIEHKVEVTHGKNLSSDQTRELCRAYASEQIEGQKAEFIRLGVLGDWANPYKTMNFANEAGEIRALAEMVKGGFVFKGLKPVNWCFDCGSALAEAEVEYQDKKSATIDVAFPVADEAKLAGAFGLAKLAKPAAIVIWTTTPWTIPANQALNVHPEFNYALVDTGERLLVLAEELVESCLARYNLEGSVIATAPGSALELINFRHPFYDRLSPVYLAEYVELGAGTGVVHSAPAYGEDDFVTCKRYGMVNDDILNPVQSNGVYATSLEFFGGQFIWKANPAIVDKLSEVGALLHTETISHSYMHCWRHKTPLIYRATAQWFVGMDKQPAAGDTLRQRALQAIEDTQFVPAWGQARLHSMIANRPDWCISRQRNWGVPIPFFLNKESGDLHPRTVELMEEVAQRVEQEGIEAWFKMDAAELLGDEAAQYDKISDTLDVWFDSGTTHWHVLRGSHPMGHESGPRADLYLEGSDQHRGWFHSSLLTGCAIDNHAPYRELLTHGFTVDENGRKMSKSLGNVIAPQKVNDTLGADIMRLWVSATDYSGEMAVSDQILQRSADAYRRIRNTARFLLSNLSGFNPATDLLPAEDMLALDRWAVDRTLLLQRELELHYGEYRFWNVYSKVHNFCVQELGGFYLDIIKDRQYTTGANSKARRSAQTALYHISEALVRWIAPILAFTADELWEYLPGERNESVMLNTWYEGLTELPADFELGREYWEGVMAVKVAVNKELEVQRAAKAVGGNLQAEVTLFAEDGLAADLAKLSNELRFVLITSTASLAPFAQAPADAVATEVPGLKLKVVKSAFPKCARCWHCREDVGVHPEHPEICGRCVDNISGAGEVRHYA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_BACFN
Sequence: MKLLLKYFPDLTEEQRKQFAALYELYIDWNSKINVISRKDIENLYEHHVLHSLGIARIIRFRAGSSVMDLGTGGGFPGIPLAILFPDTKFHLVDSIGKKVRVATEVANAIGLKNVTFRHARAEEEKQTFDFVVSRAVMPLADLIKIIRKNISPKQQNALPNGLICLKGGELEHEAMPFKHKTSMHNLNEDFDEEFFQTKKVVYVTI
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRXV_CORPI
Sequence: MGIPADNLQSRAKASFDTRVAAAELALNRGVVPSFANGEELLYRNPDPDNTDPSFIASFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPETGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSIAMPPAPVLTSPELVAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAKLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATVGNKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANGVPFDPNLPFQQEDKLDNQDVFVNFGSAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAPQKGESIFPEVDLAVEELGDILEKAEISNRKQNIADGDPDPDPSFLLPMAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSGIEIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESLLLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI
What is the function of this protein?
Catalyzes the halogenation of organic substrates in the presence of hydrogen peroxide.
What are the official names of this protein?
Vanadium-dependent bromoperoxidase, V-BPO, Vanadium haloperoxidase.
What is the protein family that this protein belongs to?
Belongs to the vanadium-dependent haloperoxidase family.
Protein: ADA1D_PIG
Sequence: MTFRDLLSVNFEGSRSDGSAGGASAGGSGGGSGGAAASEGRAVDGVPGTAGSGGVVGAGSDENNRSSAGEPGAAGAGGEVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPSIMTERKAAAILALLWAVAIVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSLCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGSSTGTDRGHGAMRSTKGHTFRSSLSLRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCHHSRRRRRPLWRAYGHHWLASNGGPRPDCAPGLGAAPREAPLALPAPEATDTPSAPEAQAPVVGRRKPPYSFRDWRLLGPFRRPTTQLRAKVSSLSQKIRAGSAPCAEAPCALRSEVEAVSLNVPHDAAEGATWQAYELADYSHLRETDI
What is the function of this protein?
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
What are the official names of this protein?
Alpha-1D adrenergic receptor, Alpha-1D adrenoreceptor, Alpha-1D adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EXG2_YEAST
Sequence: MPLKSFFFSAFLVLCLSKFTQGVGTTEKEESLSPLELNILQNKFASYYANDTITVKGITIGGWLVTEPYITPSLYRNATSLAKQQNSSSNISIVDEFTLCKTLGYNTSLTLLDNHFKTWITEDDFEQIKTNGFNLVRIPIGYWAWKQNTDKNLYIDNITFNDPYVSDGLQLKYLNNALEWAQKYELNVWLDLHGAPGSQNGFDNSGERILYGDLGWLRLNNTKELTLAIWRDMFQTFLNKGDKSPVVGIQIVNEPLGGKIDVSDITEMYYEAFDLLKKNQNSSDNTTFVIHDGFQGIGHWNLELNPTYQNVSHHYFNLTGANYSSQDILVDHHHYEVFTDAQLAETQFARIENIINYGDSIHKELSFHPAVVGEWSGAITDCATWLNGVGVGARYDGSYYNTTLFTTNDKPVGTCISQNSLADWTQDYRDRVRQFIEAQLATYSSKTTGWIFWNWKTEDAVEWDYLKLKEANLFPSPFDNYTYFKADGSIEEKFSSSLSAQAFPRTTSSVLSSTTTSRKSKNAAISNKLTTSQLLPIKNMSLTWKASVCALAITIAALCASL
What are the official names of this protein?
Glucan 1,3-beta-glucosidase 2, Exo-1,3-beta-glucanase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: ATM1_CANAL
Sequence: MFIRNVKLIKPSPVRFISPIPFSFPISRSIKISSIRYFTNKSTSNFKSTSSSSSLKSTSTSTSTSTSKTTPKTLSKPPPKVKPPIQDNDTTSSGSSSSENSESFMLKSLFKTIWPKNNLNFKIRVIIALSLLVGAKILNVQVPFYFKQIIDTMNIDWTNEVGVFSTVIGSLILAYGGARFGAVLFGELRNAIFASVAQSAIRRVAYNTFVKLLNMDLQFHLSRQTGGLTRAIDRGTKGISYVLSAMVFHIIPITLEISIVCGILTYNYGASFAAMTFVTMLAYSIFTIQTTAWRTKFRRQANNADNQAANVALDSLINYESVKIFNNELYQASKYDKALMKYQQSSVKIATSLAFLNSGQNFIFTSALTAMMYMGCQGVYTGELTVGDLVLINQLVFQLSVPLNFLGSVYRELKQSLLDMENLFQLQNQPIRIKEIPNAPPLKLNNNNNNNNNNNNNNNNSLPGEIRFENVSFGYHPDRPILNNASFTIPAGQKVAIVGPSGSGKSTILRLIFRFYDINQGRILIDGQDISKVSLESLRKLIGIVPQETPLFNDTILENIRYGRLDASDEEIYRVINQVQLNKLIDDLPDGVQTIVGERGMMISGGEKQRLAMARLLLKRAPITFFDEATSALDTHTEQALLKTIRSVFKQQHQTNVSIAHRLRTIADADKIIVLNKGQVVEEGTHWQLLNEQPNSLYAQLWNIQENLDIEKELLQGDEEEEELTEKLKLDKQELEQEAKLFNSQTFEKK
What is the function of this protein?
Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity).  Hydrolyzes ATP (By similarity).  Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).
What are the official names of this protein?
Iron-sulfur clusters transporter ATM1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ARGA_PSEAE
Sequence: MPDYVNWLRHASPYINSHRDRTFVVMLPGEGVEHPNFGNIVHDLVLLHSLGARLVLVHGSRPQIEARLAARGLAPRYHRDLRVTDAPTLECVIDAVGSLRIAIEARLSMDMAASPMQGARLRVAGGNLVTARPIGVVEGVDYHHTGEVRRIDRKGIGRLLDERSIVLLSPLGYSPTGEIFNLACEDVAMRAAIDLEAEKLILYGAEQGLLDASGKLVRELRPQQVPAHLQRLGNSYQAELLDAAAQACRAGVKRSHIVSYTEDGALLSELFTRTGNGTLVAQEQFEQLREAGIEDVGGLIELIRPLEEQGILVRRSREVLEREIEQFSIVEREGLIIACAALYPIADSEAGELACLAVNPEYRHGGRGDELLERIEERARGLGLKTLFVLTTRTAHWFRERGFQPSSVERLPAARASLYNFQRNSQVFEKSL
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_DESHY
Sequence: MGKIWVLHGPNLNLLGRREPDKYGTQTLDEINNELLHKAHTAGIPIQVEQTNFEGELIQWIHSMGPDDFLIINPGAWTHYSYAVRDAITSVQVPTIEVHLSNIHAREEFRKTSVIAPVCCGQISGLGGKSYSLALDYALEALTQK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: E1B55_ADE05
Sequence: MERRNPSERGVPAGFSGHASVESGCETQESPATVVFRPPGDNTDGGAAAAAGGSQAAAAGAEPMEPESRPGPSGMNVVQVAELYPELRRILTITEDGQGLKGVKRERGACEATEEARNLAFSLMTRHRPECITFQQIKDNCANELDLLAQKYSIEQLTTYWLQPGDDFEEAIRVYAKVALRPDCKYKISKLVNIRNCCYISGNGAEVEIDTEDRVAFRCSMINMWPGVLGMDGVVIMNVRFTGPNFSGTVFLANTNLILHGVSFYGFNNTCVEAWTDVRVRGCAFYCCWKGVVCRPKSRASIKKCLFERCTLGILSEGNSRVRHNVASDCGCFMLVKSVAVIKHNMVCGNCEDRASQMLTCSDGNCHLLKTIHVASHSRKAWPVFEHNILTRCSLHLGNRRGVFLPYQCNLSHTKILLEPESMSKVNLNGVFDMTMKIWKVLRYDETRTRCRPCECGGKHIRNQPVMLDVTEELRPDHLVLACTRAEFGSSDEDTD
What is the function of this protein?
Plays a major role to prevent cellular inhibition of viral genome replication.  Assembles an SCF-like E3 ubiquitin ligase complex based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in cooperation with viral E4orf6.  This viral RING-type ligase ubiquitinates cellular substrates and targets them to proteasomal degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3, DAXX and BLM.  Degradation of host TP53/p53 activity is essential for preventing E1A-induced TP53 accumulation that would otherwise lead to cell apoptosis and growth arrest.  E1B-55K also inactivates TP53 transcription-factor activity by binding its transactivation domain.  E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies thereby contributing to maximal inhibition of TP53 function.
What are the official names of this protein?
E1B 55 kDa protein, E1B-55K, E1B protein, large T-antigen, E1B-495R.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 55 kDa protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=Colocalizes with host TP53 to host PML nuclear bodies. PML localization of E1B-55K is necessary for E1B- 55K-dependent SUMOylation of TP53.
Protein: ACCD_BACCR
Sequence: MLRDLFVKKKKYAAIPSEQVRKDVPDGVMTKCPECKKIMYTKELLKNLKVCVNCGYHHPMNAWERLDSILDEGSFREYDKEMVSLNPLEFPGYEEKLESDRKKTELNEAVVTGEGTIDDMLVVVAVMDSRFRMGSMGSVVGEKIARAVEKAYDLQVPFIIFTASGGARMQEGILSLMQMAKTSVALKKHSNAGGLFISVMTHPTTGGVSASFASLGDYNLAEPGALIGFAGRRVIEQTVREKLPEDFQTAEFLLDHGQLDAVVHRDDMRESLRKILEVHQGGEMAVWQS
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.