PharMolix/UniProtQA huggingface dataset:
Protein: MURC_LISMC
Sequence: MTIYHFVGIKGSGMSALAQILHDKGFQVQGSDVDKYFFTQKALEEKQIPIMTFSADNIQEGLTIIAGNAFPDTHEEIERALELGLPVIRYHKFLGQLIDGYTSIAITGSHGKTSTTGLLSHVVGAIRPTSYLIGDGTGSGTKGAEYFALEACEYQRHFLAYKPTYAIMTNIDWDHPDYFKSVDDVFNAFETLGKQVKKAVFALGDDAELRKLTLDIPIIYFGFGEENEFQAKNVIKETTGTKFDVYHRGEFLGSFEIPAYGDHNVLNALSVIALCDYEGLPVEDVKKELKTFEGVKRRFSITEKANQVLVDDYAHHPSEIRATVNAARQKYPDKKVVAVFQPHTFTRTRTFLQGFADSLNLADEVYLCDIFGSAREKTGNLTIADLAHKTKGNHIIKEEHTEELLKYPEAVILFMGAGDVQKFQAAYEKVLDHEVLTEADLKKSAIN
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_BRUA4
Sequence: MTMAGNFSPLVLVGDSDRVEAEAVGAYLDNWAGKDGLRLATADAIKAILAGATRLAGRIARGSLPGDPGKLVGVNSDQDQQKCIDVGSHNLFVELLIAAGAASILSEEADLPVAGKADGLIAVAIDPLDGSGNVGLGAPLGTIFSIFPADTAEPFLQPGNRQIAAGYVSFGNSVDLGFSVGEGVIFATFDPASGIFHITRRNVTLPERTSDLAFNASVQRHLSAGMQAYVNDAFLGKDGPRGRNFNMRWLGAAVGDMHRIMQRGGLFFYVNDSRPGYEKGRLRLVYEANPIAFLAREAGGKATDGSRSILDIVPQTYHERSALVFGVAEEVDILGEYFAK
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFA_SHEON
Sequence: MSEYLLLLISTVLVNNFVLVKFLGLCPFMGVSSKLESAIGMSMATTFVLTLASILSYLVNQYLLLPFDLGYLRTMSFILVIAVVVQFTEMVVQKTSAALHRALGIYLPLITTNCAVLGVALLNVNEKHDFIQSAIYGFGAAVGFSLVLILFSAMRERLAAADVPEPFKGGAIAMITAGLMSLAFMGFTGLVK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BBIP1_NEMVE
Sequence: MADSSERAAFREVLPKQGLLFTEQTPIPVLCKPKIMPMKSVTLEKLETMQREAQEAVKRQEEEQKLQGGMI
What is the function of this protein?
Required for primary cilia assembly.
What are the official names of this protein?
BBSome-interacting protein 1, BBSome-interacting protein of 10 kDa.
What is the protein family that this protein belongs to?
Belongs to the BBIP10 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm.
Protein: YCF3_PROM9
Sequence: MPSNQNRDNFIDKAFTVIAESIVKIMPIEEKEKKAYIYYRDGLAAQNNGDYSEALEYYKESLLLEENKIDRGETLKNMAIIFMSNGEEDLSIETYEKALVENPKQPSCLKNIGLIYEKRGRNAEQNGDLDQRDIWFDKAAEVWTKAVKLYPGGYLDIENWLKNSGRSSIDMYL
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: LPXD_CAUVC
Sequence: MPDPRFFDSLGPALLSELAQAGAATLADAALGERVITHAAPLDASDAQAITFFSDAKRKDAAASTRAGACFVRPEHQGFLPPTCAALVTGRPQAAWAAAANRLHAPRRHEAGAPSLHPDAALEDGVALAPNVTIGQGASIGRGTRIGPGVVIGPGVVIGRYCRIGANAVIGFAMLGDNVAISAGAVIGEAGFGAALGPRGMVDLPQLGRVVIQDNVTLGANSCVDRGAFGDTTIGENTKIDNLVHVAHNVRIGRNCVLAAYTGVSGSTVVGDGVAFGGKAGVADHLNIGSGASIGAAASVFKDVPDGETWTGFPARPLKRWLRETAWLSRMAGGRGTRG
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: MNMG_ZYMMO
Sequence: MIFIPVMKEFFDIVVIGGGHAGCEAAAVAARMGAKTALVTMDSEQIGAMSCNPAIGGLGKGHLVREIDAWDGLMPHAADYAAIHYRMLNRSKGSAVQGPRIQADRNRYKKAIQTALKEQAHLTIIEGMAESFQMDKGKVKAVLLADGRPLKTESVVLTTGTFLDAWLFCGEKKWRGGRIGEQPSIGLAEQLKALDLPLGRLKTGTPARLDGRTIDWARLQRQPSDEDAWTMASYGAGRVAPQIACSLTRSNQKTHDIIRAGLDRSPLFSGAIEGRGPRYCPSIEDKIMKFGDRDGHQIFLEPEGLDTPLIYPNGISTSLPEDVQQAFINSIEGLENTKIVQFGYAVEYEFIDPRSLTHQLELKALKSVFCAGQINGTTGYEEAAAQGLVAGISAACAVAGKAPPVFDRRNSYIGVMIDDLVLQGVTEPYRMLTARAEYRLGLRADNAVTRLSGQAKAFGALGAEMTDFVTKRLAEREKCQKLLEKAASSRDMQAVGANVTEGASHSLFEWLRFPAVTRQHLEALIPELTEFSDAVVSEIIDDGRYAPYLERQDAELARLAGHDNMPLPAELDYATIAGLSNEMVEKFSAARPPDMASASRVRGVTPAALAAILIHAKKVTL
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDB1_MOUSE
Sequence: MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ
What is the function of this protein?
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors (PubMed:8918878, PubMed:9192866).  May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions (PubMed:8918878, PubMed:9315627, PubMed:9192866, PubMed:16815859, PubMed:18539116).  Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1 (PubMed:12150931, PubMed:8876198, PubMed:18539116).  Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression (PubMed:8918878).  Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (PubMed:9391090).
What are the official names of this protein?
LIM domain-binding protein 1, LDB-1, Carboxyl-terminal LIM domain-binding protein 2, CLIM-2, LIM domain-binding factor CLIM2, mLdb1, Nuclear LIM interactor.
What is the protein family that this protein belongs to?
Belongs to the LDB family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with SLK at leading edges (PubMed:19675209).
Protein: RUVA_STAA9
Sequence: MYAYVKGKLTHLYPTHVVVETAGVGYEIQTPNSYRFQKHLDHEVLIRTSLIVREDAQLLYGFSSEEEKDMFLSLIKVTGIGPKSALAILATSTPNEVKRAIENENDTYLTKFPGIGKKTARQIVLDLKGKVKITEEDSDSLLQVDATSTVQDQFVQEAMLALEALGYSKRELAKVEKTLNKNKYDSVDEAVKAGLQLVVS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: SYFA_METHJ
Sequence: MQLTLNEKRLLLELVKTETTTPEEMGTILDRPADSVIQYGGLLSQKGLAQVDRAVTTTLTLTEEGTQYLKEGLPERQLYDSFSESASIADLNTHPHAKIGLGWMKRLGWVKIEAGNVIKTGDPAPSPIELALKNPDAAPADIKKDLLKRGLVTEEESVRYTITITDEGKKLAAAGITLTQETGTLTADQISSGAWKDLSLRRYDITKHPRPVWPGKIHPYQRMIDEMRRILLDMGFTELHGSIIQGAFWNFDALFQPQDHPAREMQDTFHLAGKQELPVGWEKVRDMHESGGETSSTGWGGKWDPEKAKATVLRTHTTSLSIQHLAAHPEPPVKAFCIGRVYRREAIDPTHLPEFEQLEGIVMDTHVNFRNLLGYLKEFYGRMGFESVRFRPGYFPYTEPSVEPEVYIEGLGWVELGGAGIFREEVTAPWGITCPVLAWGLGVSRVAMLRMGLTDLRELYQSDIDWVRNVPVVQGGRC
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_PROMA
Sequence: MRVSRLMLVTLRDVPAEAEIVSHQLLIRGGFIKRVTSGIYAYMPLMWKVIKKITSIVQEELDSKGCLETLLPQLHPAELWKESGRWDGYTAGEGIMFHLSDRQGRELGLGPTHEEVITKIANEFLQSYKQLPVNLYQIQTKFRDEIRPRFGLMRSREFIMKDAYSFHADETNLKETYLEMNDAYEKIFKRCGLETVAVDADSGAIGGAESREFMVTAEAGEDLILLSPDKKYAANQEKAISKFADPIFLDKKEPCIIQTNGQRTIKELCDNQGFHPSQILKVIILLAVLEKNDLQPILVSIRGDQELNEVKLINAVSKYLKKSVISIKTITKEQLDSQKLLDIPLGFVGPDLKDSYLNKAANWNKKFIRFTDITASNLDSFICGANTIDQHRAFVNWSKVGGLPEIVDIRNAMPGDISIHDPKQKLIAKRGIEVGHIFQLGRKYSSCLQASFTNEMGLEEPFWMGCYGIGISRLAQASVEQNYDQSGIIWPLGIAPFEVIVIVANMKDDLQRELGEKLYSQLKDEGVDVLIDDRKERAGVKFKDADLIGIPWKIISGRDSATGIVELVERSTGISKSLKAEEAIKELLEEISNYKKSILQESL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_AZOC5
Sequence: MSDSAMEPQNPLTSGDFTAADEPFRLFSEWLKDAERSEPNDPNAMTLATVDPDGLPDARMVLLKGLDDRGFVFYTNTESAKGRELTAHPKAALVFHWKSLRRQVRVRGPVERVTDAEADAYFATRPRLSQIGAWASQQSRPLEGRFALEAAVATTTARYAVGSVPRPPHWTGFRILPVQIEFWHDRPFRLHDRVVFKRENPEIDWEKSRLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: Y940_LIMRD
Sequence: MNSQQIYETSHMISNENLDVRTITMGISLLDCIDSDSTVACQKIYDKITTKAKNLVKVGQQIEAEYGIPIANKRVTVTPISLIAAASQDHDYVKYAKTLDKAAKTLGIDFIGGYSALVQKGYQTGDRTLIASLPEALAETDFVCASVNVGSTRSGINMDAVAQMGEVVVAGSKLDMMTNAKLVIFCNAVEDNPFMAGGFHGVGEPDVVINVGVSGPGVIKTALEKVKGESMDVVAETIKKTAFKVTRMGQLVGTVGAERLGVQFGIVDLSLAPTAAAGDSVAEVLEEIGVAQVGTHGTTAALAMLNDAVKKGGIMACSHVGGLSGAFIPVSEDAGMIKAVNAGTLNISKLEAMTAVCSVGLDMIAIPGDTPKETISAMIADEAAIGMINNKTTAVRVIPAPGKKVGDTVEFGGLLGYAPVMAVNKVASTAMINRGGLIPAPIHSFKN
What are the official names of this protein?
UPF0210 protein Lreu_0940.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: YNFA_SALA4
Sequence: MLKTTLLFFVTALCEIIGCFLPWLWLKRGASVWWLLPAAASLALFVWLLTLHPAASGRVYAAYGGVYVCTALLWLRVVDGVRLTVYDWCGALIALCGMLIIVVGWGRT
What are the official names of this protein?
UPF0060 membrane protein YnfA.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PA2B_VIPRE
Sequence: MRTLWIVAVCLIGVEGSLLEFGMMILEETGKNPLTSYSFYGCYCGVGGKGTPKDATDRCCFVHDCCYGNLPDCNPKIDRYKYHRKNGAIVCGKGTSCENRICECDRAAAICFRKNLKTYNHIYKYYPDFLCKKESEKC
What is the function of this protein?
Snake venom phospholipase A2 that may have a strong anticoagulant activity (PubMed:21185324).  Is able to suppress the acetylcholine (ACh)-evoked current mediated by alpha-7-similar nAChRs in L. stagnalis neurons (IC(50)=10. 5 uM) and to compete with alpha-bungarotoxin for binding to muscle- and alpha-7 neuronal nAChR types, as well as to AChBPs (PubMed:25522251).  In inhibition of alpha-bungarotoxin binding, this toxin is mostly active against T. californica nAChR (IC(50)=0. 26 uM), it is moderately active against human alpha-7 nAChR (IC(50)=14 uM), and is not active against L. stagnalis and A. californica AChBP (IC(50)>30 uM) (PubMed:25522251).
What are the official names of this protein?
Basic phospholipase A2 vurtoxin, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: INHBE_HUMAN
Sequence: MRLPDVQLWLVLLWALVRAQGTGSVCPSCGGSKLAPQAERALVLELAKQQILDGLHLTSRPRITHPPPQAALTRALRRLQPGSVAPGNGEEVISFATVTDSTSAYSSLLTFHLSTPRSHHLYHARLWLHVLPTLPGTLCLRIFRWGPRRRRQGSRTLLAEHHITNLGWHTLTLPSSGLRGEKSGVLKLQLDCRPLEGNSTVTGQPRRLLDTAGHQQPFLELKIRANEPGAGRARRRTPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.
What are the official names of this protein?
Inhibin beta E chain, Activin beta-E chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: LAMP1_HUMAN
Sequence: MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
What is the function of this protein?
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
What are the official names of this protein?
Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A.
What is the protein family that this protein belongs to?
Belongs to the LAMP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Cytolytic granule membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980).
Protein: YL002_MIMIV
Sequence: MRKNLLRILKEKDMSMTKKGYISLYDFVEKIIGSKNPVAYASKIKDHNPVIINEKEYISPESCLNILKNAKFAKCRELYNNLQVKDGDKTSIIDVNNNIFQFEGKRFTSFFVDKRDGKWDVWIYGAEVARFLGYNDDKKAISIHVESCNRLIFEEIRNNFPIESNSIPKTLDKKTKFINLSGFCNLIHHSKKPFAMKIKKWLDDEVIPALIMDGVYSMQPKELKVKFFYEDNYISDFLLRVIKNRE
What are the official names of this protein?
Uncharacterized Bro-N domain-containing protein L2.
Protein: GLNE_ECODH
Sequence: MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYAAWLQEALCNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSYLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSEGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLSAIAELHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPSDELNRARLAWAMDFADWPQLTGALTAHMTNVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLTLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: TM2D2_XENLA
Sequence: MRWPVPPLGYLLLGGQGLLLTFSLISSQNNTSPVTYPDINVSAAPEPRDPLGPLVLCSYLPEEFVECDDPVDHMGNGTAQQELRYGCKKFGGQAYGDVEHTQVMCRALDGIECDGSRSFLRGNRPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTWGGLGIWWFVDLILLITGGLMPSDNSNWCTIY
What are the official names of this protein?
TM2 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the TM2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CFLAR_HUMAN
Sequence: MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
What is the function of this protein?
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells.  Acts as an inhibitor of TNFRSF6 mediated apoptosis.  A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex.  Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis.  Lacks enzymatic (caspase) activity.
What are the official names of this protein?
CASP8 and FADD-like apoptosis regulator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
Protein: Y1052_HAEIN
Sequence: MDYLDKLTHLAQVRGEINIRCEFQGEWQISHQEKDAGKGIFHLIEQGECWLTLNEKQFHLKEGDVFFLPQNQPHSMHYSANKRADIPTKKSHQGLFELHQIGRGTPDLKMFCGNFYYQQDALLTASMPEYLHINLCDTPIHPLVQLFLQEAQKNDAGTKSVVDALSNVLLIYILRHAIQQNLIEQGILFALQDKRLNTALIAILQQPQNDWHIEQLAELATMSRANFIRIFQQHIGMSPGRFLTKVRLQSAAFLLKQSQQSVLAIALEVGYQSEAHFCKVFKNYYQLSPSQYRKSVSL
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator HI_1052.
Protein: CEX1_ASPNG
Sequence: MSSTTSSSRSDLEKVPVPQVTPRDSDSDKGSLSPEPSTLEAQSSEKPPHHIFTRSRKLQMVCIVSLAAIFSPLSSNIYFPALDDVSKSLNISMSLATLTITVYMIVQGLAPSFWGSMSDATGRRPVFIGTFIVYLVANIALAESKNYGELMAFRALQAAGSAATISIGAGVIGDITNSEERGSLVGIFGGVRMLGQGIGPVFGGIFTQYLGYRSIFWFLTIAGGVSLLSILVLLPETLRPIAGNGTVKLNGIHKPFIYTITGQTGVVEGAQPEAKKTKTSWKSVFAPLTFLVEKDVFITLFFGSIVYTVWSMVTSSTTDLFSEVYGLSSLDIGLTFLGNGFGCMSGSYLVGYLMDYNHRLTEREYCEKHGYPAGTRVNLKSHPDFPIEVARMRNTWWVIAIFIVTVALYGVSLRTHLAVPIILQYFIAFCSTGLFTINSALVIDLYPGASASATAVNNLMRCLLGAGGVAIVQPILDALKPDYTFLLLAGITLVMTPLLYVEDRWGPGWRHARERRLKAKANGN
What is the function of this protein?
Transmembrane transporter that exports citrate across the cell membrane.
What are the official names of this protein?
Citrate exporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CFI2_FRAAN
Sequence: MAQSVTGIQIGGTSFPPAVKPPGSGNTLFLGGAGVRGMEIQGNFVKFTAIGVYLEDKAVPALSVKWKGKTAEELTESVEFFREIVTGPFEKFTQVTMILPLTGQQYSEKVSENCVAIWKKFGIYTDAEAKAIEKFIEVFKDQTFPPGASILFTQSPNGSLMIGISKDGSIPEVGNAVIENKLLSESVLESIIGKQGVSPEARKSVATRLSELLKESDHCVAGNEKVDECTKEAENKA
What is the function of this protein?
Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones.  Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity).
What are the official names of this protein?
Chalcone--flavanone isomerase 2, Chalcone isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the chalcone isomerase family.
Protein: KCY4_ORYSJ
Sequence: MGSVVDAPTVVAGQEEVTDNMLGDKKVTVVFVLGGPGSGKGTQCANIVEHFGFIHLSAGDLLRAEIKSGSENGTMIENMIKEGKIVPSEVTIKLLQEAMIKSGNDKFLIDGFPRNEENRAAFENVTKITPAFVLFFDCSEEEMERRLLGRNQGRVDDNIETIRKRFKVFVESSLPVIEYYNAKDKVKKIDAAKPIPEVFEDVKAIFAPYAPNAA
What is the function of this protein?
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP.  Plays an important role in de novo pyrimidine nucleotide biosynthesis.  Has preference for UMP and CMP as phosphate acceptors.
What are the official names of this protein?
UMP-CMP kinase 4, Deoxycytidylate kinase 4, CK 4, dCMP kinase 4, Uridine monophosphate/cytidine monophosphate kinase 4, UMP/CMP kinase 4, UMP/CMPK 4.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.