PharMolix/UniProtQA huggingface dataset:
Protein: CINA_LEVBA
Sequence: MQAEIIAVGTEILLGQIVDTNSAFIARELAEAGIEVYYHSLVGDNATRLTAVVEQARSRSDLVIISGGLGPTKDDLTKQTVAHLLGVKLVEDALAMAKIRRRFAINGREMTPNNRLQALYPAGSQPLANRTGLAVGAFYQDPDGADIMLLPGPPSETEPMFREQALPLLKQTYPRSEYLSSRVLRFFGIGESQLVTQLSDLIDQQTNPTIAPYAKVNEVTLRLTAQAPDEMQGQRLLDDLTATIKARVGDYLYGYGDDNSLAAVVVQTLIDRQLTITAAESLTAGQFQSTLGSVPGVSAVFPGGFVTYAASAKHDLLGVSQATIDQDGVVSAATAKEMASRSRERLDTDFSLSFTGVAGPDALEGQPAGTVWLGLAQRGQQPQAKLLHLTGTRSAIRERSVLTGLDWLRRTLQKVK
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: PDXB_SALPB
Sequence: MKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPINFVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIGIVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKDGPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDLNVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETLLPAPEFGRITLHGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDETAAALLCKLGFNAVHHPAH
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E2F1_RAT
Sequence: MAVAPAGGQHAPALEALLGAGALRLLDSSQIVIISTAPDVGAPQVPTGPAAPPAGPRDPDVLLFATPQAPRPAPSAPRPALGRPPVKRRLDLETDHQYLAGSSGPFRGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSRTMVGIGQRLEGLTQDLQQLQESEQQLDHLMHICTTQLQLLSEDSDIQRLAYVTCQDLRSIADPAEQMVIVIKAPPETQLQAVDSAETFQISLKSKQGPIDVFLCPEESAEGISPGRTSYQETSGEDRNADSGTAGPPPSPPSTSPTLDPSQSLLGLEQEAVLPRIGNLRAPMEEDRLSPLVAADSLLEHVKEDFSGLLPGEFISLSPPHEAVDYHFGLEEGEGIRDLFDCDFGDLTPLDF
What is the function of this protein?
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication.  The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase.  E2F1 binds preferentially RB1 in a cell-cycle dependent manner.  It can mediate both cell proliferation and TP53/p53-dependent apoptosis.  Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters.  Directly activates transcription of PEG10.  Positively regulates transcription of RRP1B.
What are the official names of this protein?
Transcription factor E2F1, E2F-1.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURG_MYCTU
Sequence: MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSVSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTLRGLETRLVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAVATGAGARTTT
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS16_METPP
Sequence: MVVIRLARGGSKKRPFYNIVAAPARIRRDGRFLERVGFYNPVAAGGEEPLRVAFDRIDHWVSHGAQLSPTVARLVKDAKAKVAPAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: TILS_STAAR
Sequence: MQLNSNGWHVDDHIVVAVSTGIDSMCLLYQLLNDYKDSYRKLTCLHVNHGVRSASIEEARFLEAYCERHHIDLHIKKLDLSHSLNRNNSIQNEARIKRYEWFDEMMNVLEADVLLTAHHLDDQLETIMYRIFNGKSTRNKLGFDELSKRNGYQIYRPLLAVSKKEIKQFQERYHIPYFEDESNKDNKYVRNDIRNRIIPAIDENNQLKVSHLLKLKQWHDEQYDILQYSAKQFIQEFVKFDEQSKYLEVSRQAFNNLPNSLKMVVLDCLLSKYYELFNISAKTYEEWFKQFSSKKAQFSINLTDKWIIQIAYGKLIIMAKNNGDTYFRVQTIEKPGNYIFNKYRLEIHSNLPKCLFPLTVRTRQSGDTFKLNGRDGYKKVNRLFIDCKVQQWVRDQMPIVLDKQQRIIAVGDLYQQQTIKQWIIISKNGDE
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y639_AROAE
Sequence: MMKGGIAGLMKQAQQMQENMKKMQDQLASVEVEGQSGAGMVKVLMTCKYDVRRVTIDDSVMDDKEMLEDLLAAAVNDAVRRVETTTQEKMAGFTSGLNLPPGMKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein AZOSEA06390.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PROA_CLAM3
Sequence: MPSNVPAAPITTAEVLPADELERILEAARTASTSLAASTSVQRDAALDAIAAALVSGADRIVAANAEDLAAGRDAGLAAGLLDRLTLDARRVASLADAVTGIRGLDDPLGLVVRGRTLPNGLLLSQVRVPFGVVGAIYEARPNVTVDIAALALKSGNAVVLRGGSAALRTNAVLVDVMRGALERVGLLAHAVQTVDAHGRAGAARLMRARGLVDVLVPRGSAELIRTVVAESTVPVIETGAGVVHVYLDASADARMSVDIAVDAKVSRPSVCNAMETLLVHRDAAPRVLVAVLDALRDRGVTVHGDAAVRAMWPDAVPATDEDWAAEYLSLDLAVRVVDSVEDAVAHIARWSTHHTESIVTSDLAVAERFLAAVDSAVVMVNASTRFTDGSEFGFGAEVGISTQKLHARGPMGVQELTSTKWIVRGSGQVRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXF1A_SCODE
Sequence: MKFHIIFCLLAALMMTSAFAEVTVEPLRHSNKNPTESECKKACADAYAKGDQSKIPEAHNFRDYYCNCHVIVQ
What is the function of this protein?
Voltage-gated sodium channel inhibitor.
What are the official names of this protein?
Mu-scoloptoxin(15)-Ssd1a, Mu-SLPTX(15)-Ssd1a, Toxin SSD800.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-15 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TUSB_PECAS
Sequence: MLHTLSCSPYHADLDTLLRSLEQGDALVLLQDGVIAALVGGDIIHRLLDSAVLLYALRPDTEARGMTEQISNSVVLIGYNEFVQLTVEHPQQLAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBT_LEPBJ
Sequence: MNPNELIVKLQSKIDLKTKPPGSLGTLESLALQIGLIQNTDSPELKSPHILVFAGDHGLANSGVSAYPKEVTYQMVFNFLNGGAAINAFCKQNSIRLKVVDAGVDFSFSDDSTFLHPDFIDAKVGFGTKNILIESAMTKEECNQALEKGAFISTKKVSSNCNVIGFGEMGIGNTSSASLITASVLKKDLREVTGKGTGLNDQKFQKKITILEECLCKHQSSLRTPFEVLQTFGGFEIAMMIGAMIDSAKKGRIILVDGFIATSAFLIAHKMEPTILKNAVFCHKSVEPGHIHLLEEWNAKPLLDLGLRLGEGAGCAIAFPILLSAIAFLNDMASFESAKVDQKL
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: TMUB2_BOVIN
Sequence: MISRHLQNNLMSVDPVSSQAMELSDVTLIEGVGNEVTVVAGVVVLILALVLAWLSTYVADSGSNPLLGTIVSAGDTSVLHLGHVDHLVAGQGTPEPTELPHPSEGNDEKAEEAGEGGGDPTGEPGAGGGVEPSLEHLLDIQGLPKRQAGPGNSSLEAPVRSEDSTCLPSSPSLISVRLKFFNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVAGPSSSLAPSSTTEPPNLGVSVGSLMVPVFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR
What are the official names of this protein?
Transmembrane and ubiquitin-like domain-containing protein 2.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LPXK_COLP3
Sequence: MRLIEKVWFNDHPAKWLLVPMLLPLSALFWLISTLRRLSYKIGLSRSCQLSKPVIVVGNIGVGGNGKTPIVLYLVELTRLLGLTPGVISRGYGGKAPHYPYLLDEKSTSIEAGDEPILIQQRCQVPIAVGSDRIASAKLLIAQGCDIIISDDGLQHYRLARDLELVVVDGKRLFGNGLLLPAGPLREGLWRLPKSDLVIYNGKNDQDYQEKNYPCMHMTLAATELCNLLTGERIYLTDFIRLNDSVNAIAGIGAPQRFFDTLKEHQFKVINQQSFVDHHAFVLADFNEFDDNIPLLMTEKDAVKCHDFCKENWWYLPVDATFSDADRQLIIDRTQIAVQSVIQ
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: AK3_ECOLI
Sequence: MSEIVVSKFGGTSVADFDAMNRSADIVLSDANVRLVVLSASAGITNLLVALAEGLEPGERFEKLDAIRNIQFAILERLRYPNVIREEIERLLENITVLAEAAALATSPALTDELVSHGELMSTLLFVEILRERDVQAQWFDVRKVMRTNDRFGRAEPDIAALAELAALQLLPRLNEGLVITQGFIGSENKGRTTTLGRGGSDYTAALLAEALHASRVDIWTDVPGIYTTDPRVVSAAKRIDEIAFAEAAEMATFGAKVLHPATLLPAVRSDIPVFVGSSKDPRAGGTLVCNKTENPPLFRALALRRNQTLLTLHSLNMLHSRGFLAEVFGILARHNISVDLITTSEVSVALTLDTTGSTSTGDTLLTQSLLMELSALCRVEVEEGLALVALIGNDLSKACGVGKEVFGVLEPFNIRMICYGASSHNLCFLVPGEDAEQVVQKLHSNLFE
What are the official names of this protein?
Lysine-sensitive aspartokinase 3, Aspartate kinase III, AKIII, Lysine-sensitive aspartokinase III.
What is the protein family that this protein belongs to?
Belongs to the aspartokinase family.
Protein: SNTAN_HUMAN
Sequence: MGGCMHSTQDKSLHLEGDPNPSAAPTSTCAPRKMPKRISISKQLASVKALRKCSDLEKAIATTALIFRNSSDSDGKLEKAIAKDLLQTQFRNFAEGQETKPKYREILSELDEHTENKLDFEDFMILLLSITVMSDLLQNIRNVKIMK
What is the function of this protein?
May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.
What are the official names of this protein?
Sentan, Protein S100-A1-like, S100 calcium-binding protein A1-like.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Expressed exclusively at the cilium tip where it localizes between the cell membrane and peripheral A-subfibers.
Protein: PCKA_SHEDO
Sequence: MTDGAPRTFLNPTSAELVEIALQRGEGRLTANGALVALTGARTGRSPADRFIVKEPSSEADIEWGPVNKPFDAGAFDALWGRVEAYLSEKELFVSELEVGADDEHYLPVRVTTEYAWHQLFARNLFITPEHFNRGDKGVWQIINAPGFVCDPSRDGTHSDAVVILNFAERKVLLAGLKYAGEMKKSMFSVQNFLLPAKGVLPMHCSANVGQDGDTTLFFGLSGTGKTTLSADPKRFLIGDDEHGWAKGGVFNIEGGCYAKCIDLSQKNEPVIWDAIRFGTVLENVMLDENRVPNYKDSSLTENSRAAYPLEHIAQRKVENRGNEPHAVVFLTCDVSGVLPPVSILTKEQAAYHFLSGYTAKVGSTEMGSTSAIQSTFSTCFGAPFFPRPAGVYAELLIERIESFNSQVYLVNTGWTGGPHGVGKRFDIPTTRAIVDAIVSGSLKDAPTEHLATLNLAVPLAIEGVDSTLLNPINTWADKDMYAKYAKQLAQEFNSNFAKYQVSEAIKQAGPKA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR17_MAIZE
Sequence: MLLLSSPFVSVSPPPPPLSSHGARPALRIEAARQLTGRVVTTKADKTVGVEVVRLAPHPKYKRRERIKKKYQAHDPDNQFKVGDVVELQPSRPISKTKHFLAIPLPPRDTRRKSQLLPPLQSDDDQEPSSRE
What is the function of this protein?
In the hcf60 mutation the Activator tag is inserted 17 base pars upstream of the initiation codon.  This mutation is seedling lethal, due to plastid ribosome insufficiency.  However under non-light stressed conditions photosynthesis and oxygen evolution can occur.
What are the official names of this protein?
30S ribosomal protein S17, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYS_RIPO1
Sequence: MLDLKQIRENPDYIQELLNRRSASNEYDLTPILDRDRQQRDIEATRTQLQARSNEIGKLIGQKMKSGINPQSEEIQALKTEGNDLKTQLSELEPQEKQLKSEIEALLLQLPNLPSESTPLGKSEADNVEVRRWGDEYLPKIEVLPHWEIAERLGILEVERAVKIAQSRFIALVGAGAALERALINFMLDCQINAGYLEVIPPVLINSDSLQGTGQLPKFAEESFKCSEDDLWLAPTAEVPVTNLYRDEIVEAEQLPIKHCAYTPCFRREAGSYGKDTRGLIRLHQFNKVELVKLVHPETSEAEHQSLVNNAEAILQALKLPYRVLELCTGDLGFGATKCYDLEVWLPSSGTYREISSCSNCGDFQARRANIRLKEKGKKGTQYVHTLNGSGLAVGRTMAAILENYQQSNGTVKVPDVLQPYLKREIL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_DICT6
Sequence: MPTKKDYYEILGVPRNATQDEIKQAYRRLVRQYHPDLNKDPSAHEKFKEINEAYEVLSDPQKRAQYDQFGHVGDFSGYGDFQGGWQPGGFDFGDLGRNFEDIFENFFGDSIFGDLFGRRREREKAPRKGADLRYDINITLEEAAFGSEKEIYVTRLETCPTCKGKGTEPGTNPVKCDMCNGTGQIRNMRQTPFGQFVQITTCPKCHGTGQIIINPCHECHGTGKVRRKRRVEFKIPAGVDEGYVIRLAGEGEPGENGGPNGDIYIHIHIIPHKIFKRDNEDIWMELPIDYLIALLGGEVEVPTLEGKEKIYIKPGTQTGEVITLKGKGIPYLRNKNQRGDQKIVVKITVPQNLSPKEKELLLEIAKLRGINIEKDKNIFEQIKKAFKGDN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALM_MACPY
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIIEAFKVFDKDGNGFISAAELRHIMTNLGEKLTDEEVDEMIREADIDGDGQINYEEFVKMMMAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: RBL_WEISI
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVSPQPGVPPEEAGAAVA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UPF3_YEAST
Sequence: MSNVAGELKNSEGKKKGRGNRYHNKNRGKSKNETVDPKKNENKVNNATNATHNNSKGRRNNKKRNREYYNYKRKARLGKSTENEGFKLVIRLLPPNLTADEFFAILRDNNNDDGDKQDIQGKLKYSDWCFFEGHYSSKVFKNSTYSRCNFLFDNLSDLEKCANFIKTCKFIDNKDNITIPDMKLSPYVKKFTQTSKKDAALVGTIEEDEIFKTFMNSMKQLNENDEYSFQDFSVLKSLEKEFSKSIELENKIAERTERVLTELVGTGDKVKNKNKKKKNKNAKKKFKEEEASAKIPKKKRNRGKKKRENREKSTISKTKNSNVVIIEEAGKEVLKQRKKKMLLQEKLKISNSSQPQSSSAQTQPSFQPKENLFVPRVKILHRDDTKK
What is the function of this protein?
Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
What are the official names of this protein?
Nonsense-mediated mRNA decay protein 3, Up-frameshift suppressor 3.
What is the protein family that this protein belongs to?
Belongs to the RENT3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NECT2_MOUSE
Sequence: MARAAVLPPSRLSPTLPLLPLLLLLLQETGAQDVRVRVLPEVRGRLGGTVELPCHLLPPTTERVSQVTWQRLDGTVVAAFHPSFGVDFPNSQFSKDRLSFVRARPETNADLRDATLAFRGLRVEDEGNYTCEFATFPNGTRRGVTWLRVIAQPENHAEAQEVTIGPQSVAVARCVSTGGRPPARITWISSLGGEAKDTQEPGIQAGTVTIISRYSLVPVGRADGVKVTCRVEHESFEEPILLPVTLSVRYPPEVSISGYDDNWYLGRSEAILTCDVRSNPEPTDYDWSTTSGVFPASAVAQGSQLLVHSVDRMVNTTFICTATNAVGTGRAEQVILVRESPSTAGAGATGGIIGGIIAAIIATAVAGTGILICRQQRKEQRLQAADEEEELEGPPSYKPPTPKAKLEEPEMPSQLFTLGASEHSPVKTPYFDAGVSCADQEMPRYHELPTLEERSGPLLLGATGLGPSLLVPPGPNVVEGVSLSLEDEEEDDEEEDFLDKINPIYDALSYPSPSDSYQSKDFFVSRAMYV
What is the function of this protein?
Modulator of T-cell signaling.  Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to.  Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG.  Upon interaction with PVRIG, inhibits T-cell proliferation.  These interactions are competitive.  Probable cell adhesion protein.
What are the official names of this protein?
Nectin-2, Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, Murine herpes virus entry protein B, mHveB, Nectin cell adhesion molecule 2, Poliovirus receptor homolog, Poliovirus receptor-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the nectin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RF1_MAGMM
Sequence: MAIEEKLESLTSRHAELSAHLADPTTVSDSKRFAAYSKEFSDLEPVVAAWQAHLAILQQLAETDEMLAEAGDDAEMRQMAREERETLKNKLEQSQKHLHLMLLPKDPNDDKNVILEIRAGTGGEEAALFVSDLFRMYGRFAEIKGWRIEMLSSSATDLGGYKELIAMVQGKGAYMGLKYESGVHRVQRIPVTETGGRIHTSAVTVAILPEADEVELHIEDKDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGLVVICQDEKSQHKNKAKAMKVLQARLLDAQQQAADSQRAEARKGQVGSGDRSERIRTYNFPQSRVTDHRINLTLHKLDQVLQGGLAEVVDALTAHDQASKLAHLGGGD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXH_ECOSE
Sequence: MATLFIADLHLCVEEPAITAGFLRFLAGEARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: EX7S_CHLPD
Sequence: MAVTSAKKNPGSPGIEELISRLEEITRNIENPETGIENSIALYEEGLAIAEQCKKRLQEARKKIEIINPELAKNWPDTARNRDLFDSEI
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSF_PROM9
Sequence: MSQSIIESKNKKDVNNGKIPAKETILSPRFYTTDFEAMENMDLSINEEELEAICEEFRKDYNRHHFVRNSEFDGAAEKLDPETRELFVDFLEGSCTSEFSGFLLYKELSRRIKDKNPLLAECFAHMARDEARHAGFLNKSMSDFGLQLDLGFLTANKDYTYFPPRSIFYATYLSEKIGYWRYIAIYRHLEKNPDSKIFPLFNYFENWCQDENRHGDFFDALMKAQPRTVKSLSQKINIGGTTFTHPLFDYFHRFRYFLNNLPITSKLWSRFFLLAVFATMYARDLGIKKDFYSSLGLDAREYDQYVINKTNETSARVFPVVLDVYDKSFYGRLDKIVENNKVLSNIANSEENKVSKTLKKLPTYLSNGYQLLRLYLLKPLDSKDFQPSIR
What is the function of this protein?
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis.  Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).
What are the official names of this protein?
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, Mg-protoporphyrin IX monomethyl ester oxidative cyclase.
What is the protein family that this protein belongs to?
Belongs to the AcsF family.
Protein: KITH_CLOAB
Sequence: MYRPKDHGWVEVIVGPMYSGKSEELIRRIRRAKIAKQKIQVFKPEIDNRYSKEDVVSHMGEKEQAVAIKNSREILKYFEEDTEVIAIDEVQFFDDEIVEIVNKIAESGRRVICAGLDMDFRGKPFGPIPELMAIAEFVDKIQAICVVCGNPATRTQRLINGKPAFYDDPVVLIGAMESYEARCRKCHVVPQKKEV
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T629_SHISO
Sequence: MMPLLDKLREQYGVGPLCSELHIAPSTYYHCQQQRHHPDKRSARAQRDDWLKKEIQRVYDENHKVYGVRKVWRQLLREGIRVARCTVARLMAVMGLAGVLRGKKVRTTISRKAVAAGDRVNRQFVAERPDQLWVADFTYVSTWQGFVYVAFIIDVFAGYIVGWRVSSSMETTFVLDALEQALWARRPSGTVHHSDKGSQYVSLAYTQRLKEAGLLASTGSTGDSYDNAMAESINGLYKAKVIHRKSWKNRAEVELATLTWVDWYNNRRLLERLGHTPPAEAEKAYYASIGNDDLAA
What is the function of this protein?
Involved in the transposition of the insertion sequence.
What are the official names of this protein?
Transposase for insertion sequence element IS629.