PharMolix/UniProtQA huggingface dataset:
Protein: PYRC_HELHP
Sequence: MPQTLQLTNPMDMHLHLREGEMLSAILPFSANPFSAAVVMPNLKTPITTTAQALAYKRQILSLCSTSFEPLMSIFLTPDLDKQELIRAKEAGIHILKLYPKGSTTGSEKGVKEMLCEKTLHIFEIAQELGFILSIHGESNGFCMEREYEFLPIFAHIAQHFPRLRIIIEHMSDRRSLELIEQYPNLYATLTLHHITMNLDDVLGGGINPHHFCKPMLKTKKDQQALLQAALNAHPKVSFGSDSAPHLESAKLNSKGAAGIFSAPILLPALAEVFAFHNALDCLQTFISNRAIANYKLKHFPIKTITLERVENPVPPYINTPLGHIIPLRAQTNLSWRIKEENR
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: CHLN_AUXPR
Sequence: MTNSKLTETLTFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNALGVMIFAEPRYAMAELEEADISAQLNDYKELKRLCLQIKQDRNPSVIVWIGTCTTEIIKMDLEGMAPRLEAEIQTPIVVARANGLDYAFTQGEDTVLAAMVQRCPSNAPEQNQIEKKSLVLFGSLPTNVATQLNLELERCGIQVAGWLPSQRYADLPVLNQNVYVCGINPFLSRTATTLMRRRKCKLISAPFPIGPDGTRAWLEKICSVFNVAPINLIERERLIWDSLEDYIALLRGKSVFFMGDNLLEISLARFLVRCGMIVYEIGIPYLDKRFQSAELQLLEKTCSEMNVAMPRIVEKPDNYNQIQRIRELQPDLAITGMAHANPLEARGINTKWSVEFTFAQIHGFTNARDILELVTRPLRRNKALENLGWNQLVKM
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CYSA_CAUVC
Sequence: MTIAIRSVEKQFGRYPALNKVDLEIADGELLALLGPSGSGKTTLLRTIAGLEFPDAGQVLFDGQDVTYASAAARRVGFVFQQYALFKHMTVAKNIAFGLDVRKGKDKPSKAEIARRVEELLKLVELEGLGGRYPSQLSGGQRQRVALSRALAVQPSVLLLDEPFGALDATVRKSLRRELRRVHDATGVTTIFVTHDQEEALELADRVAILNNGRIEQIGTPDQVHDAPETAFVCGFVGEANRFDGQVSGGRFKAGALTVPASALKDGAATAYVRPHDFALDEAGFEVLIERAQVQGALTAVTALTSDGRRLEISASRADADRFTGAVKIVARKAHVYAA
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BRK10_ASCTR
Sequence: APVPGLSPFR
What is the function of this protein?
Induces relaxation of mouse trachea that has been precontracted with methacholine.  May induce relaxation of arterial smooth muscle.  May target bradykinin receptors (BDKRB).
What are the official names of this protein?
Bradykinin-like peptide AR-10.
What is the protein family that this protein belongs to?
Belongs to the bradykinin-related peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: DUSTY_CANLF
Sequence: MEGDAPQRVSERVSGPGPGGGGGGMIRELCRGFGRHRRYLGQLRQNLRETQKFFRDIKCSHSHSCPSSPAGGGAAELGPAGDVAEAPLPAGQLSCIAFPPKEEKYLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTRLGSEENCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWDTIPEEDLEVQEDSEDAAHVLAELEVTMHHALLQDVDIVVAPCQGLRPAVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPIFFFKVPKLGSEIIASSTRRTENERSPLHHQLMDLGYLSSSHCNCGVPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTHLVDAAKALNRVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMICETLNTMKGELLDDAANMEFKDVIVPENGEAVGTRELKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSIHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVNPPTITLEWKRKVAQEAIDSLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLENTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPSQRPLLGIVQPMLQGIMERLCKSNSERPNTGLDDST
What is the function of this protein?
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation.  Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death.  In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
What are the official names of this protein?
Dual serine/threonine and tyrosine protein kinase, Dusty protein kinase, Dusty PK, Receptor-interacting serine/threonine-protein kinase 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction. Note=Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.
Protein: HSLO_CLOBK
Sequence: MKDKLVKAIAKDGQVRIIGAITTELVNEGVKLHNCAPTAAAALGRMLTAGALMGTTLKSEKDTLTLQIHGGGIAKGVVVTSYADGHVKGYIGNPTADIEPNSKGKLDVSGIIGKNGNLLVIRDMGLKEPYIGQVPIYTGEIGEDLAYYYTVSEQTPSAVGLGVLVDKDLSIKSAGGFIIQMMPGADEMLADLISYRLEEIPSITEMISKGMTIEEILEYIFEDMDLKILESIAPEYRCDCSREKVERALASIGQKDLKEIYDEGKEEELKCHFCNKAYVFSHDEVGDILENYYSEK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOEH_DROME
Sequence: MSPKALNVRVTTMDAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKVMNQDVKKENPLQFRFRAKFYPEDVAEELIQDITLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGFLANDRLLPQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTDLWLGVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVRINKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARERAEKKQQEYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQAAKDELELRQKELQAMLQRLEEAKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAALLAASTTPQHHHVAEDENENEEELTNGDAGGDVSRDLDTDEHIKDPIEDRRTLAERNERLHDQLKALKQDLAQSRDETKETANDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFENM
What is the function of this protein?
Involved in connections of major cytoskeletal structures to the plasma membrane (PubMed:8666669).  Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr (PubMed:23544124).  In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles (PubMed:28554770).
What are the official names of this protein?
Moesin/ezrin/radixin homolog 1, Ezrin-moesin-radixin 1, Moesin, dMoesin, Protein D17.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm. Nucleus, nucleoplasm. Chromosome. Note=Nuclear localization is dependent on Nup98 and Rae1. Associated with the active ecdysone-regulated loci on polytene chromosomes and heat shock-induced puffs. Colocalizes with messenger ribonucleoprotein (mRNP) particles probably through interaction with the mRNA export factor PCID2.
Protein: RS18_YERPE
Sequence: MARYFRRRKFCRFTAEGVVEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARCIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: IGKC_MOUSE
Sequence: RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
What are the official names of this protein?
Immunoglobulin kappa constant, Ig kappa chain C region MOPC 21.
Protein: PGK_CHLAA
Sequence: MNKKTIRDVDWAGKRALVRVDFNVPLDDQGQITDDTRIRAALPTIRYLLEHGASVVLMSHLGRPKGKPNPKYSLRPVVERLFELLPEAKEVKKTEAITGPAAEAAVAMLKPGQVLVLENTRFDPREEPNDPAMAAELAKLGDVFVNDAFGTAHRANASTEGVAHYLPAVAGFLMEKELTYIGGALNNPQRPFVTVIGGAKISDKIGVIENLLGKVDALLIGGGMANTFLLAKGLNVGDSLVEPDSVPVAQQLMARAEERGARLLLPVDVVIADAFSADAQRQVVDVSDIPAGWRVLDIGPKTIERYSAEIRAARTVIWNGPMGVFELEPFAVGTRAIAQAMAEAAANGAITIVGGGDSVAAVEQAGLADKMSHVSTGGGASLELLEGRVLPGVAALQDAE
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_CLOK1
Sequence: MKIVLASASSRRRQLLSRLIENFQVVVSDFDEDSVVFQGRCESYVMKLAEGKAKDVCRKLTNESSIVIGCDTAVFLRGKVMGKPRDIQEAFHMLKALSGNEHDVYSGIAIMDKVLHKTVKSFVRTTVKFSEIDDRCIKNYLKKGEYKDKAGAYGIQGYGGVFVKEIHGCYYNVVGLPLNKLYNMLSGMGVNL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_STRPB
Sequence: MLIFPLINDTSRKIIHIDMDAFFAAVEERDNLALKGKPVVIGKDPRETGGRGVVSTCNYEARKYGIHSAMSSKEAYERCPKAIFISGNYEKYRTVGEQIRRIFKRYTDVVEPMSIDEAYLDVTNNKLGIKSAVKIAKLIQHDIWKEVGLTCSAGVSYNKFLAKLASDFEKPHGLTLVLKEDALCFLAKLPIEKFHGVGKKSVEKLHDMGIYTGQDLLAVPEMTLIDHFGRFGFDLYRKARGISNSPVKSDRIRKSIGSERTYAKLLYQETDIKAEISKNAKRVAALLQDHKKLGKTIVLKVRYADFTTLTKRVTLPELTRNAAQIEQVAGDIFDSLSENPAGIRLLGVTMTNLEDKVADISLDL
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIP_HUMAN
Sequence: MRLLQLLFRASPATLLLVLCLQLGANKAQDNTRKIIIKNFDIPKSVRPNDEVTAVLAVQTELKECMVVKTYLISSIPLQGAFNYKYTACLCDDNPKTFYWDFYTNRTVQIAAVVDVIRELGICPDDAAVIPIKNNRFYTIEILKVE
What are the official names of this protein?
Prolactin-inducible protein, Gross cystic disease fluid protein 15, GCDFP-15, Prolactin-induced protein, Secretory actin-binding protein, SABP, gp17.
What is the protein family that this protein belongs to?
Belongs to the PIP family.
What are the subcellular locations of this protein?
Secreted.
Protein: TMM91_HUMAN
Sequence: MDSPSLRELQQPLLEGTECETPAQKPGRHELGSPLREIAFAESLRGLQFLSPPLPSVSAGLGEPRPPDVEDMSSSDSDSDWDGGSRLSPFLPHDHLGLAVFSMLCCFWPVGIAAFCLAQKTNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDPP
What are the official names of this protein?
Transmembrane protein 91, Dispanin subfamily C member 3, DSPC3.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PSTB_XANAC
Sequence: MHRIAVPAATGAPTAQAPVKVAARNLDFYYDKYHALKSINIEIPEKRVTALIGPSGCGKSTLLRIFNRIYALYPKMEARGEVLLDNENILSPKYPMNRLRSKVGMVFQKPVPFPMTIFENVAYGIRHHEKLSKADMQNRVEQALRQGALWDEVKDKLGQSALGLSGGQQQRLCIARAVALRPDVLLLDEPTSALDPISTSRIEQLVEELKRDYTIVIVTHNMQQAARVSDYTAFMYLGDLIEHDRTETIFSQPSKQQTEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CP125_MYCTO
Sequence: MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSAELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH
What is the function of this protein?
Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection.  Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate.  Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
What are the official names of this protein?
Steroid C26-monooxygenase, Cholest-4-en-3-one 26-monooxygenase, Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming], Cholesterol C26-monooxygenase, Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming], Cytochrome P450 125, Steroid C27-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: CLPP_MAGMM
Sequence: MSLVPMVVETTNRGERAYDIYSRLLKERVVFLVGQVEEHMANLVVAQLLFLESENPEKDIHLYINSPGGSVTAGMAIYDTMQFIRPSVSTLCIGQAASMGAVLLAAGEAGKRLVLPNARVMIHQPLGGFSGQASDFEIHAREILRIRENLNQVLSHHTGKPLEQVQLDTERDNFLSATEAVEYGLVDKVISHRELPEAEAES
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPM7_RAT
Sequence: MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLATKYSDVKLGEHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQSEAVHLFQTMMECMKKKELITVFHIGSEDHQDIDVAILTALXXGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVSFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLIRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNASSSTPQLRKSHETFGNRADKKEKMRHNHFIKTAQPYRPKMDASMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLEYKTKAEMSHIPQSQDAHQMTMEDSENNFHNITEEIPMEVFKEVKILDSSEGKNEMEIHIKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKIREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFVGFGLRFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEEPSWSLAKDIVFHPYWMIFGEVYAYEIDVCANDSALPTICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDVPVRPMWKKPSVVNTLSSSLPQGDRESNNPFLCNIFMKDEKDPQYNLFGQDLPVIPQRKEFNIPEAGSSCGALFPSAVSPPELRQRRHGVEMLKIFNKNQKLGSSPNSSPHMSSPPTKFSVSTPSQPSCKSHLESTTKDPEPIFYKAAEGDNIEFGAFVGHRDSMDLQRFKETSNKIRELLSNDTPENTLKHVGAAGYNECHKTPTSLHSETESCSRRASTEDSPDVDSRAALLPDWLRDRPTNREMPSEGGTLNGLASPFKPVLDTNYYYSAVERNNLMRLSQSIPFVPVPPRGEPVTVYRLEESSPSILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVLCTWSEHDVLRSGHLYIIKSFLPEVINTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDESSDLNLQAGNSTKESEATNSVRLML
What is the function of this protein?
Essential ion channel and serine/threonine-protein kinase.  Divalent cation channel permeable to calcium and magnesium.  Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death.  Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx.  The kinase activity is essential for the channel function.  May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell.  Phosphorylates annexin A1 (ANXA1) (By similarity).
What are the official names of this protein?
Transient receptor potential cation channel subfamily M member 7, Long transient receptor potential channel 7, LTrpC-7, LTrpC7, Transient receptor potential-phospholipase C-interacting kinase, TRP-PLIK.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: RSMH1_AGARV
Sequence: MSEEKQHKRRVHYSGKYPKKFEEKYKELNPEKYKDTIEHVISKGNTPAGMHISIMVKEIIDFLDIKPGQTGFDATLGYGGHTRAMLEKLEGQGHMFATDVDPIESEKTKKRLAEAGFGEDILTIKLQNFCTIDEIAKEVGGFDFILADLGVSSMQIDNPERGFSFKVDGPLDLRLNPNAGISAAERLDNISREELSGMLYENSDEPYCEELAKAITDEIRKGNRIGTTTKLRHIIEQTLDFLPEKDKKDIIKKTCQRTFQALRIDVNHEFEVLYEFMEKLPGALKPGGRAAILTFHSGEDKLVKKALKAGYKAGIYSDYSKDVIRPSAQECAQNGRARSTKMRWAVRAE
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H 1, 16S rRNA m(4)C1402 methyltransferase 1, rRNA (cytosine-N(4)-)-methyltransferase RsmH 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GFRA3_HUMAN
Sequence: MVRPLNPRPLPPVVLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRPQPWVPSLFSCTLPLILLLSLW
What is the function of this protein?
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin).  Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
What are the official names of this protein?
GDNF family receptor alpha-3, GDNF receptor alpha-3, GDNFR-alpha-3, GFR-alpha-3.
What is the protein family that this protein belongs to?
Belongs to the GDNFR family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: AROC_CUPPJ
Sequence: MSGNTLGLLFTVTTFGESHGPAIGAVVDGCPPGMDLTEADIQGDLDRRKPGTSRHVTQRKEPDQVEILSGVFEGKTTGTPICLLIRNTDQRSKDYGNIVETFRPGHADYTYWQKYGIRDYRGGGRSSARLTAPVVAAGAVAKKWLREQFGTEIRGYMSKLGEIEVPFSDWSHVPENPFFAANADIVPELETYMDALRRDGDSVGARIEVVASNVPVGLGEPLFDRLDADIAHAMMGLNAVKGVEIGAGFKSVEQRGSEHGDELTAQGFRGNNAGGILGGISTGQDITVSLAIKPTSSIRTPRESIDKAGNAATVETFGRHDPCVGIRATPIAEALLALVLVDHALRHRAQCGDVKVDTPRIPAQAPGQPG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ATPD_PHATC
Sequence: MSVNPLTLKIASPYARALFDFSVEKNIMHQITADFQNLEIFLKENTELTEYLDNPVVSKNAKCEILAKTLQAQLNDETLKFLMILVERGRISLLTSVITIYLELVYETASIKTIEVSTAFEFTTSQKTILVQKLKELMNAREIRLMITVDPNLIGGFLIKTQSKVIDFTIKNQLQKLAKHLDTVLEI
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, chloroplastic, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: YIPF6_MOUSE
Sequence: MAEAEDSPGEQEAAASKPLFAGLSDVSISQDIPIEGEITIPSRARAQEHDSSTLNESIRRTIMRDLKAVGRKFMHVLYPRKSNALLRDWDLWGPLILCVTLALMLQKSSIDGKNDGGGPEFAEVFVIIWFGAVTITLNSKLLGGNISFFQSLCVLGYCILPLNIAMLICRLLLLAGQGPINFMIRLFVVLLMFAWSVVASTAFLADSQPPNRKALAVYPVFLFYFVISWMILTFTP
What is the function of this protein?
May be required for stable YIPF1 and YIPF2 protein expression.
What are the official names of this protein?
Protein YIPF6, YIP1 family member 6.
What is the protein family that this protein belongs to?
Belongs to the YIP1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Note=Evenly distributed between cis- and trans-Golgi apparatus. Mainly localizes within medial-/trans- Golgi and trans-Golgi network (TGN), while less so within cis-Golgi.
Protein: LEUD_CLOPA
Sequence: HAPIALKAAGVSCVIAKSFARIFYRNSINIGFPILECEEAVNDAKNNHELEVDFTTGIIKNITLGKEYKAQAYPQFMIDIMKNEGLINCVKNGALNSFMR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: Y427_MYCPN
Sequence: MTKTSKASGLSWFFCDLDGTLLRYQNNQHLIEPTTKRAVAQLVESGANFVVATGRKPSDVRNIYKELGIEQASPYLIANNGAVVWDLKRNSYLNKQTLSLSDFDLIDHINQTLNQLNHEYGCILYGLNDQVYFYHIHAPDSQAFKQYFAFYEGEFVQNQYLEIDGLKTEYNLVKAIWFFKEVHQQKAVIAQHFTNQERLVITSAHSFELVPLNVSKGHAINLIKQQVKITDNQIMVLGDSYNDLPMFQHGVVKVTNHLAPDNLKQLATRVYELPASLFVGQALNDYFKFD
What are the official names of this protein?
Putative phosphatase MPN_427.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: YWRE_BACSU
Sequence: MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKWIEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMFMLLIYVCTL
What are the official names of this protein?
Uncharacterized protein YwrE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.