PharMolix/UniProtQA huggingface dataset:
Protein: PYTB_ASPTN
Sequence: MRFLGIAAVATFSTVVSAYPKSTALYNCVSSVFGPSAPQRIVTPNDTTYLDSRLGETIQFDELPVLLAYAQESKEIAPLIRCAKTAGIKAVPRAGGHSFEAYSALNGTLIIDIAHLNYVNVSDDRQTAVVGAGIRLGALYTALSEHGTSFIGGICPTVGLAGFLGSGGFNMQQRSQGLAVEHVLAAKVVLADGRTVVASPDTNPDLFFAIRGGGGGTYGIVVEFTLSLTSIPRSAMLMLSWNDTASRFPAAKQYLDWAPKQIPEFMSQINVYRDKVQVLGWYYGGTEDELRSLVNASGLLDIGKPAVVIAGGCNTDNARAFGYTTMECLPDGKVDVSILNVVPDPFSKVGNSTQFKWNEVPKSTSMPVADPWQRFHRMSKSFFVLKDNPLTDQTLQSLLDRIASLDAKSQVWGEWHAWNISTPSKGSGNAFAWREKAYAHLEFQIHGAPDDKERQSTYENWLEDLESYLRPTVGGASYSGYLDADISTDPLTSYYGGNVCKLVSVKRKTENDYSSSTVEQLFIDSDVNARKITSRYPIPPPDKSIKTEDITLQDCWVRIYTPPSATSSGSVAVFIHGGGWIMGSPDIEDATCRRICRCSGMTVVSVGYRLAPKFQFPTGLNDCVRATLWTLGHFPVSALVIMGGSAGANLAFGVALKLVDAGLGEKVKGVLALVPATVHPDAVPADKRDQYTAMHENANNTVNTLAAMDCFLDAYAAPPHDKYFSVLLHPRLKDLKKVYLVECGTDTLRDDARLMRDALEEAGVPLMYDAYPGYPHYFWSYPSPVLAEASESFHENMLQALAWLDQE
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of pyranterreones, a family of antioxidative compounds (PubMed:32077283).  The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase pytA that condenses 4 malonyl-CoA units ato the acetyl starter unit by the modular PKS of pytA (PubMed:32077283).  The acyl chain is then connected to an L-serine through the amide bond by the modular NRPS of pytA (PubMed:32077283).  A tetramic acid is formed and released from the PKS-NRPS pytA to give pyranterreone 5 with the help of the thioesterase pytI (PubMed:32077283).  Pyranterreone 5 could be methylated by pytC to afford pyranterreone 6 (Probable).  Both pyranterreones 5 and 6 are subsequently oxidized by the FAD-linked oxidoreductase pytB and the cytochrome P450 monooxygenase pytD to form the fused gamma-pyrone core, resulting in pyranterreones 7 and 11, respectively (PubMed:32077283).  The hydroxy group at C-8 of pyranterreones 7 and 11 are dehydrated by the aspartyl protease pytH to form a delta-7 double bond to give pyranterreones 3 and 1, 2 accordingly (PubMed:32077283).  The exo-methylene of pyranterreone 3 could be reduced into a pendant methyl by reductase pytE to provide pyranterreone 4, also known as cordylactam (Probable).  Pyranterreone 4 can be reconverted to pyranterreone 3 through pytB-catalyzed dehydrogenation or further oxidized to pyranterreones 9 and 10 (Probable).
What are the official names of this protein?
FAD-linked oxidoreductase pytB, Pyranterreones biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: MNME_ENT38
Sequence: MSHNDTIVAQATPPGRGGVGILRISGLKAREVAEAVLGKLPKPRYADYLPFNDADGTALDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTLPGLRIAKPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSTRVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNTVMADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLRDASDEVERIGIERAWQEIEQADRVLFMVDGTTTSAVDPADIWPDFIARLPAKLPITVVRNKADMTGETLGLSDVNGHSLIRLSARTGEGVEDLRNHLKQSMGFETNMEGGFLARRRHLQALEAAANHLDQGKAQLLGAWAGELLAEELRLAQQSLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS4_SYNJA
Sequence: MPHASAFLEVIPAIDLLQGRAVRLYQGDYAQAEQVAADPVQQAEIWATQGAPRLHVVDLDGAKSGDPVNLPIIADIVRKLAIPVQVGGGIRSLERARQLLDLGVERVIVGTVAVEDPALLEAMTQALPGRIWVGIDARQGQVATRGWLSTTPLAATELVQRVQAQGAAGIIYTDIGRDGTLAGPNLEQLRQILAVSRLPVIASGGIGSLTDLLALLSLPGLAGAILGKALYSGAISLPEALRAVGPGRWQDLPPETGSRWA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRXX_ARATH
Sequence: MDSIVSSSTILMRSYLTPPVRSCSPATSVSVKPLSSVQVTSVAANRHLLSLSSGARRTRKSSSSVIRCGGIKEIGESEFSSTVLESAQPVLVEFVATWCGPCKLIYPAMEALSQEYGDKLTIVKIDHDANPKLIAEFKVYGLPHFILFKDGKEVPGSRREGAITKAKLKEYIDGLLNSISVA
What is the function of this protein?
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
What are the official names of this protein?
Thioredoxin X, chloroplastic, AtTrxx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: POTA_BACC1
Sequence: MKKIIKVEAVEKHFGNQVIIPPLSLDIKEGEFLTILGPSGCGKTTLLRMIAGFETPTKGNLLLDDEKINDLPPYKRHMNLVFQHYALFPHMNVEKNICFGMKMQKVPAAEQKERAEEAMRLTQLLEFRNRKPAKLSGGQQQRVAIARAIVNNPRVLLLDEPLGALDFKLRKDLQRELKNLQRNLGITFIYVTHDQEEAMSMSDRIVVMNKGHIEQIGTPKEIYNKPKTLFVATFIGENNIVKNGEGYVAIRPENVKVRSVEEPILKEYHLGHIEDIEFVGNMEKLYVRDEKTSELLMAYQTAEEAAQWSIGDNVYVGWEQEDEVTLN
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TIG_AKKM8
Sequence: MEINVDIQPDCTATLKASIPAETTAARRASIVDSYAAKAKLPGFRPGKTPKSIIEKRFKKEMEEELLDTLFETACSTALEENPKLKVLSFGKPEQSLDDQGNYTATSTMTVVPEFELPEYKGIEVKVPSSEVTEADVEEALNSLAEQIAEFTPVDRAAQKDDVAIIDFKTTLDGKPVAEAVGKPVGFLEGRDGQWMKVEDDQFLPGFASALEGLNAGDSKDITVTIPDTFPITELRGKELVFHATVKEVREKQLPAMDDAFAEKVLPGKNLEELKTALKENLAQRKAMQIDEAKADQITEKLADMLDFNLPEAVVEREVYGILQQKMQQAMYSGNAPADMDKFVEEAREEAKQEAKRNLKVFFMLQEVAQVEKIAVTEMELYNEVARQARQQKKNLKSYIRELQREGRVHGIRMSLLTAKVLDFLTKEAKVTVDEQ
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RL14_STRPD
Sequence: MIQQETRLKVADNSGAREILTIKVLGGSGHKFANIGDVIVASVKQATPGGAVKKGDVVKAVIVRTKTGARRPDGSYIKFDDNAAVIIRDDKTPRGTRIFGPVARELREGGYMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: KCD14_HUMAN
Sequence: MWQGCAVERPVGRMTSQTPLPQSPRPRRPTMSTVVELNVGGEFHTTTLGTLRKFPGSKLAEMFSSLAKASTDAEGRFFIDRPSTYFRPILDYLRTGQVPTQHIPEVYREAQFYEIKPLVKLLEDMPQIFGEQVSRKQFLLQVPGYSENLELMVRLARAEAITARKSSVLVCLVETEEQDAYYSEVLCFLQDKKMFKSVVKFGPWKAVLDNSDLMHCLEMDIKAQGYKVFSKFYLTYPTKRNEFHFNIYSFTFTWW
What are the official names of this protein?
BTB/POZ domain-containing protein KCTD14.
Protein: APAG_CAUVC
Sequence: MRRRRGSDSAAYEARTRDIVVRVFPTYAAEESSPEQGLYLWSYTVEIENHGEETVTLIARRWTITDGFNRVNEVEGSGVVGEQPELKPREAFRYVSNCPLPTPSGAMRGSYQMVTDAGDLFDVAIPEFSLHLPGAAMKLN
What are the official names of this protein?
Protein ApaG.
Protein: SYC_YERP3
Sequence: MLKIFNTLSRQKEEFKPIHAGKVGMYVCGITIYDLCHIGHGRTFVAFDVVARYLRYLGYSLTYVRNVTDVDDKIIKRAIENNETCEQLTTRMLAEMHKDFDALNLERPDLEPRATHHIAEIIEMTERLIARGHAYVASNGDVMFAVDSDPDYGVLSRQDLDQLQAGARVEVADVKRNPMDFVLWKMSKPGEPRWESPWGPGRPGWHIECSAMNGKQLGAHFDIHGGGSDLMFPHHENEIAQSTCAHDGPYVNYWMHSGMVMIDKEKMSKSLNNFFTIRDVLAYYDAETVRYFLMSGHYRSQLNYSEENLKQARASLERLYTALRGTDANATPAGGAEFEARFRTAMDDDFNTPEAYSVLFDIAREVNRLKNEDMAAANGLAAELRKLAQVLGLLEQDPELFLQGGAQADDDEVAKIEALIKQRNDARSSKNWALADAARDQLNELGIVLEDGPQGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_PSESM
Sequence: MSEPRKILVTSALPYANGPVHLGHMLEYIQTDMWVRFQKHRGNQCIYVCADDAHGSAIMLRAEKEGITPEQLIDNVKAEHSADFADFLVDFDNFHSTHSDENRELSSMIYTRLRDAGHIATRSVTQYFDPEKKMFLADRFIKGTCPKCAAVDQYGDNCEKCGATYAPTDLKDPKSAISGATPVLKDSKHFFFDLPAFDTMLKSWTRSGTLQDAVANKIAEWLDSGLQQWDISRDAPYFGFEIPDEPGKYFYVWLDAPIGYMASFKNLCARRPDLDFDAYWGKDATTELYHFIGKDIVNFHALFWPAMLEGADLRKPTGVNVHGYLTVNGQKMSKSRGTFIKARTYLDHLPPEYLRYYYASKLGRGVDDLDLNLEDFVQKVNSDLIGKVVNIASRCAGFIHKGNAGVMVDANAAPELTDAFLAAAPSIADAYEARDFARAMRETMALADRANAYIAEKAPWALAKQEGKQDEVQAVCALGVNLFRQLVIFLKPVLPNLAADAEKFLNVAPLTWDDHKTLLTHHQLNPFSALMTRIDPLKVEAMAAASKEDLTATDTSTDAAPAGNGELAKDPLSAEIDFDAFAAVDLRVALILKAEHVEGADKLLRLTLDIGDEQRNVFSGIKSAYPDPSKLEGRLTMMIANLKPRKMRFGISEGMVMAAGPGGEEIYLLSPDSGAKPGQRIK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VEGFC_HUMAN
Sequence: MHLLGFFSVACSLLAAALLPGPREAPAAAAAFESGLDLSDAEPDAGEATAYASKDLEEQLRSVSSVDELMTVLYPEYWKMYKCQLRKGGWQHNREQANLNSRTEETIKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAANKTCPTNYMWNNHICRCLAQEDFMFSSDAGDDSTDGFHDICGPNKELDEETCQCVCRAGLRPASCGPHKELDRNSCQCVCKNKLFPSQCGANREFDENTCQCVCKRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNRQKACEPGFSYSEEVCRCVPSYWKRPQMS
What is the function of this protein?
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels.  May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults.  Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
What are the official names of this protein?
Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular endothelial growth factor-related protein, VRP.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVC_ECO8A
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNAQLRDVNEAIRCHAIEQVGKKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: NUON2_AQUAE
Sequence: MDLRALIGVIEIPDLKKFLPEFILLLLAFILFTLELFIKGKERRLVLNVVSYVGYFSVLMSLLIPWMYKGDTFYGNFTNDPLAVTVKIFAVLITLAILPFASSYFSAKKSFYGEFYYILAFTLLGVFVLASTYNLIILYVALELVSVGFYILTALLRGSTEAKEGAFKYLILGGLSIALASYGAAFMYIYSGSLDLREILTYQGKDIHYLVLGLVFFLIGLAVKIGAVPFHYWVPDAYQGAPTPVTALMASVGKLAFFIPLVRVMPLVQEKFSLVWTITVGVIAALTMLYGNLVALVQKDVKRLLAYSSIAHSGYIMAGAAVAKVIGMKAVIYFLVAYAVMSAGAFLVLALMEKNPEWQNYMENFYGLRFNAPYIAFAFFVYMVALLGVPPTVGFVGKALVFMALSFDKLWWLAFIMILSAAISTGYYIRLVVVMYMHEREKEIRSAPSHLGEKFSLFALTLASVLLGVLPSLVWFLIKQSAENLFTG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N 2, NADH dehydrogenase I subunit N 2, NDH-1 subunit N 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SPEA_BACCR
Sequence: MSQYETPLFTALVEHSKRNPIQFHIPGHKKGQGMDPTFREFIGHNALAIDLINIAPLDDLHHPKGMIKEAQDLAAAAFGADHTFFSIQGTSGAIMTMVMSVCGPGDKILVPRNVHKSVMSAIIFSGAKPIFMHPEIDPKLGISHGITIQSVKKALEEHSDAKGLLVINPTYFGFAADLEQIVQLAHSYDIPVLVDEAHGVHIHFHDELPMSAMQAGADMAATSVHKLGGSLTQSSILNVKEGLVNVKHVQSIISMLTTTSTSYILLASLDVARKRLATEGTALIEQTIQLAEHVRDAINSIEHLYCPGKEMLGTDATFNYDPTKIIVSVKDLGITGHQAEVWLREQYNIEVELSDLYNILCLITLGDTESDTNTLIAALQDLAATFRNRADKGVQVQVEIPEIPVLALSPRDAFYSETEVIPFENAAGRIIADFVMVYPPGIPIFTPGGNYYTRKLRVYS
What is the function of this protein?
Catalyzes the formation of agmatine from arginine.
What are the official names of this protein?
Arginine decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-I family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UFD2_SCHPO
Sequence: MSDLEKIRLKRLAKLQQTNSEANSSKEPKESNIAPEPKKPDLKKRFIGSKATTSNSEQKEISPPVTSGAPKHRLFSKDEWMHFITCQALNITLSETDSSKYYLEGFKKDLEEEGSPLLFNENNVDSALLSRLSTTGNNTFSYLLQSWSFLYQYKKRLPKDENQDFKIHYLSLLKSLLVSYAGIVVMLPDTFNSETIDLAEVLIGAEGIPLEFLSEFVQRFEHENLDELFIPVLESLSLKIGLMNVDTVQMNVMQIILQLVSLKPIALLLPKLPSWNPTNNAGEIEYKTFLGRISSLSVFTQDVASRYFSNSTERSAQNISSSISSLKLTMSTYQDVLFQIFNTLIRTSTSLRESVLDFFAMVVNANHKRQSIQVNHFDITSDACMLNFSHVLSRLSEPFLDIGCSKIDRVQVEYFRRNPRVDIKEETKLNADQKASESFYSKPAEGSNNFISDIFFLNLAFHHYGVNATFKALEQLVQSIRDSEKLKERLETEQQNMSGSFQATRLTAQLSRLDQRLDLDRSFVHCYEIMLTQTSDTSRSFSFLNFVAIWLSRLADGQSSTYPKMPLSLPFNENAPEAFKCLPEYFIETITDYMLSLFKTSSSTLTLHSLEPLCEFCVSFLTQANYIKNPYLRAKLAEILYFGVQTHVGRSELLLDVVRTSKVATRWLLPALMAFYIEIESTGQSTQFYDKFNIRFYICEVFRTIWKQPAYFGKLEQEQKTNLPFFVKFVALMLNDATYLLDEALLKLTEIHNLQSLLADAISNSNSNQNVQESQSNLAAAERQASTYCQLGNETIFMLKLFTSSIPKAFCAVEIVDRLAAMLNYNLQALCGPKCSNLKVEDPTKYHFNAKTLLSIIFDVYLNLCNEPAFVEAVAHDGRSYSKEIFERATSIMTKHNLKSSFDIEAIKEFVNRVEAFRLQEATEEEDMGDIPDYFLDPLMFTIMKDPVVLPRSGISIDRSTIKAHLLSDATDPFNRTPLTLDDVTPNDTLREEINTFLKSKRNKHSRNSE
What is the function of this protein?
E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly.  Binds to cdc48 and elongates mono- and diubiquitinated ERAD substrates presented by the ufd1-npl4-cdc48 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties.  Delivers these polyubiquitinated substrates to downstream ERAD components, which target them to the proteasome.  Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety.
What are the official names of this protein?
Ubiquitin conjugation factor E4, Ubiquitin fusion degradation protein 2, UB fusion protein 2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin conjugation factor E4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PPIL4_MOUSE
Sequence: MAVLLETTLGDVVIDLYTEERPRACLNFLKLCKIKYYNYCLIHNVQRDFIIQTGDPTGTGRGGESIFGQLYGDQASFFEAEKVPRIKHKKKGTVSMVNNGSDQHGSQFLITTGENLDYLDGVHTVFGEVTEGMDIVKKINETFVDKDFVPYQDIRINHTVILDDPFDDPPDLLIPDRSPEPTKEQLDSGRIGADEEIDDFKGRSAEEVEEIKAEKEAKTQAILLEMVGDLPDADIKPPENVLFVCKLNPVTTDEDLEIIFSRFGPIRSCEVIRDWKTGESLCYAFIEFEKEEDCEKAFFKMDNVLIDDRRIHVDFSQSVAKVKWKGKGGKYTKSDFKEYEKEQDKPANLVLKEKVKPKQDAKYDLILDEQGEDSKSSHSHTSKKHKKKTRHCSEEKEDEEYMPIKNPNQDIYREMGFGHYEEEESCWEKQKNEKRDRRQNRSRSRSRERDGHYSNSHKPKYQTEPYERERSRKRDRSRSPKKSKAKEKSKYR
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase-like 4, PPIase, Cyclophilin-like protein PPIL4, Rotamase PPIL4.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: METJ_YERPP
Sequence: MAEWNGEYVSPYAEHGKKSKQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPNDEDLRKERSDEIPEAAKILMRELGVDPDTWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_BURO0
Sequence: MSEIRKNDHRLMQVLLAPVISEKATLVADKNEQVVFEVAPDATKQEVKAAVELLFKVEVDSVNVLVQKGKQKRFGRSMGRRKDVKKAYVCLKPGQEINFEAEAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: CTU2_PHANO
Sequence: MPGKHSDSATSELCEKCKENISILVVRAKPICHDCFARYVHTKAIKRLESFRVNFAASPDQQRKILLPLSHGVSSTTLLHILDLHLNTQRSKTNRTGFAISVLVVDEGSLDPARLDKVRERYANHDYASLPLHDVFRLLPDDASLRAFLPESQVQEVCSTQEQLTSLIASLTSATARADVLTTLRTRLIVEHAKQTGCESILWGDSTTRLAEKTLAETAKGRGFSLPWQISDGKSPFDINFHYPLRDVLKKELFSYVDLAEPALSALVYEPQSGATQASMSSKNTTIDDLMKQYFESVEENFPSIVSNVVRTTGKLEVPTGATSNPRCSLCGMPVPDGRFGIHGWGGDQHGGADDAAAVSGGSLCYGCTRSIPQRGTAVASK
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LARP1_MOUSE
Sequence: MATQVEPLLPAGAPLLQAEEHGLARKKPAPDAQAESGPGDGGGEPDGGVRRPRPACARPGRDGAERESPRPPAAAEAPAGSDGEDGGRRDFVEAPPPKVNPWTKHAPPPAAVNGQPPPEPSAPAKVVRAAAPKPRKGSKVGDFGDAVNWPTPGEIAHKSVQPQSHKPQPARKLPPKKDMKEQEKGDGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGSKHKWVPLQIDMKPEVPREKLASRPTRPQEPRHTPAVRGEMKGSEPATYMPVSVAPPTPAWQPETKVEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGTEGPRTHKYMNNITYYFDNVSSNEIYSMDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEMVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSESWIEVKKRPRPSPARPKKPEEPRFSHPTALPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSEEDSDYEIDDRDVNKILIVTQTPPYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTPRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPAVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHPVVAGGSGEGRKRCPSQSSSRPATGISQPPTTPTGQATREDAKWTSQHSDTLTLRK
What is the function of this protein?
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability.  Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery.  The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1.  When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA.  Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif.  Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes.  Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis.  Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation.  Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis.
What are the official names of this protein?
La-related protein 1, La ribonucleoprotein domain family member 1.
What is the protein family that this protein belongs to?
Belongs to the LARP family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic granule. Note=Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.
Protein: UBA5_DROVI
Sequence: MSNAIDELQAIIAELKSELEEQKTCTRNARERIERMSAEVVDSNPYSRLMALQRMNIVKDYERIRDKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLFFTPDQAGLSKVEAAARTLSFINPDVRIETHNYNITTVDNFDKFLSTISESGMQQGQPVDLVLSCVDNFEARMAINAACNENNLNWFESGVSENAVSGHIQFIRPGDTACFACAPPLVVAENIDERTLKREGVCAASLPTTMGITAGLLVQNALKYLLNFGEVSDYLGYNALNDFFPKMTLKPNTQCDDRHCLQRQKEFQERPKPVLQQVEEVSDEPLHASNDWGIELVADDAPVAEQAPKATDTANVASGLRLAYEAPEKEAVDQAGHAAAGDGMPETSLEDLMAQMKSM
What is the function of this protein?
E1-like enzyme which activates UFM1.
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme 5, Ubiquitin-activating enzyme 5.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
Protein: HIS3_MYCBP
Sequence: MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDAAVLLEPDD
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.