PharMolix/UniProtQA huggingface dataset:
Protein: MALK_MANSM
Sequence: MANVSLRNVGKSYGDVHISKDINLEINEGEFVVFVGPSGCGKSTLLRMIAGLEDITTGELYIGEKLMNDVEPSKRGIGMVFQSYALYPHLDVADNMSFGLKLAGVKKNERDQRVNQVAEILQLAHLLDRKPKALSGGQRQRVAIGRTLVSQPEVFLLDEPLSNLDAALRVQMRVEISKLHKKLNRTMIYVTHDQVEAMTLADKIVVLNAGGVAQVGKPLELYHYPANRFVAGFIGSPKMNFLPVKVTAVEENQVKIELPDANHHNFWIPVSGEGVNIGENLSLGIRPEHLVPAEQAQVSLRGIVQVVELLGNETQIHLEIPEIKQPSLIYRQNDVILVNEGDEMNIGIVPERCHLFKEDGTACQRLFAEKGV
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Maltose/maltodextrin import ATP-binding protein MalK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PAND_CAMJ8
Sequence: MNITLLKSKIHRASVTEARLDYIGSISIDEKLLQASGILEYEKVQVVNVNNGARFETYTIATQEEGVVCLNGAAARLAEVGDKVIIMSYADFNEEEAKTFKPKVVFVDENNTATKITNYEKHGAIF
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNN_SALHS
Sequence: MKIGIIGAMEEEVTLLRDKIDNRQTITLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLASTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAESCIRELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPDAVAVEMEATAIAHVCYNFSVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSTLMVETLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: TRPF_PSESM
Sequence: MSAVRSKICGITRIEDALAAAEAGADAIGLVFYPKSPRAVTVLQARAIIAALPPFITTVGLFVNASRCELNETLDAVALDMLQFHGDETPEECDGYHRPYIKALRVKAGDDIAQACRTYRNARGVLLDTYVEGVPGGTGETFDWALIPDDLDKPVILAGGLTSANVAQAIAQVRPYAVDVSGGVEKSKGIKDREKILAFMSAVHGT
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RSMJ_AGRFC
Sequence: MKEQNESFVVDFVGGAVGHRFRSGEGRGQALPKAAGFTKGRTPKIVDATAGLGRDAFLLASLGAEVTLIERSPGMHAHLADGISRALEAGGAYAEAASRMTLLQGDSRQLLKELSPEVVVIDPMHPPRHNTALVKKEMRVLRELVGSDPDQVELMEVALAHATKRVVLKWPLRADPMPGIRKPSHQIIGKNTRYDVFMIFGNSLDQQE
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIN4_DANRE
Sequence: MPPKGKGGKGAKGAAASGSGDSDKKEKAQKGGTAVKVRHILCEKHGKCMEAMEKIKSGMRFSEVAAQYSEDKARQGGDLGWMTRGSMVGPFQDAAFALPISTMDKPVYTDPPVKTKFGYHIIMVEGKK
What is the function of this protein?
May be involved as a ribosomal RNA processing factor in ribosome biogenesis.  Binds to DNA (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, Parvulin-14, Par14, Peptidyl-prolyl cis-trans isomerase Pin4, PPIase Pin4, Rotamase Pin4.
What is the protein family that this protein belongs to?
Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.
Protein: ATPE_TRIEI
Sequence: MTLTVRVIAPDKTIWDKEAQEVILPSTTGQLGILGGHAPLLTALDTGVMRVRAENDWIAIALMGGFAEIEADEVSILVNGAERGDNIDTEKARLAYEEAEKRLQTSESSDNLQEKIKAKQTLKRARARLQAAGGMVN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: HEM1_VIBPA
Sequence: MSLLAIGINHNTASVDLREKVAFGPDKLGPALEQLREHEAVNGSVIVSTCNRTELYCDVKQGARNKLIDWLAQFHQVSREDLMPSLYVHEEQAAIKHLMRVSCGLDSLVLGEPQILGQVKQAFSDSRDHQAVDSSIDKLFQKTFSVAKRVRTETDIGGNAVSVAYAACTLAKHIFESLSDSTVLLVGAGETIELVAKHLASNGCTKMIVANRTKERAQGLAEQFGAEVISLNEIPDYLARADIVISSTASPLPIIGKGMVETALKQRRHQPILLVDIAVPRDVEAQVGELNDAYLYSVDDLQSIIDSNIEQRKVEAIQAEAIVSEESASFMTWLRSLQAVDSIRDYRKSANEIREELLSKSLQSLAAGADPEKVLRELSNKLTNKLIHAPTRALQSAAEQGEPAKLTIIRQTLGLDDL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: FD6E1_SOYBN
Sequence: MGLAKETTMGGRGRVAKVEVQGKKPLSRVPNTKPPFTVGQLKKAIPPHCFQRSLLTSFSYVVYDLSFAFIFYIATTYFHLLPQPFSLIAWPIYWVLQGCLLTGVWVIAHECGHHAFSKYQWVDDVVGLTLHSTLLVPYFSWKISHRRHHSNTGSLDRDEVFVPKPKSKVAWFSKYLNNPLGRAVSLLVTLTIGWPMYLAFNVSGRPYDSFASHYHPYAPIYSNRERLLIYVSDVALFSVTYSLYRVATLKGLVWLLCVYGVPLLIVNGFLVTITYLQHTHFALPHYDSSEWDWLKGALATMDRDYGILNKVFHHITDTHVAHHLFSTMPHYHAMEATNAIKPILGEYYQFDDTPFYKALWREARECLYVEPDEGTSEKGVYWYRNKY
What is the function of this protein?
ER (microsomal) omega-6 fatty acid desaturase introduces the second double bond in the biosynthesis of 18:3 fatty acids, important constituents of plant membranes.  It is thought to use cytochrome b5 as an electron donor and to act on fatty acids esterified to phosphatidylcholine and, possibly, other phospholipids.
What are the official names of this protein?
Omega-6 fatty acid desaturase, endoplasmic reticulum isozyme 1.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: G6PI_BURPS
Sequence: MTLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTDATLALLVRLAREAGVEARRDAMFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAKMARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALHHVATPDIATHFVSNVDGADLARVLERIDPEATLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSANPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFRTAPLERNLPVLQGLVGIWYRNFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDGAFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIAVLTPEHPLASHHPKLLANCFAQSEALMLGRTLDEARKIVGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEHKVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAA_HAEI8
Sequence: MFIDTSELCDLYAEQVDVVEPIFSSFGGVSHFYGKVTTVKCFESNGLIAEVLEENGEGRVLVIDGGGAVRRGLIDAELAQLAVDNGWEGIIVYGAVRQIQQLENLDIGIHALAPIPVSADESSAGESDIPVNFGGVTFFPEDYIYADLTGIILSQEPLDLED
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_STRE4
Sequence: MTNEFHHVTVLLHEAVDMLDIKPDGIYVDATLGGSGHSAYLLSLLGDKGHLYCFDQDQKAIDHAQEQLKPYIDKGQVTFIKDNFRHLKARLLEHGVTEIDGILYDLGVSSPQLDERERGFSYKQDAPLDMRMDSQAALTAYEVVNTYDFNDLVRIFFKYGEDKFSKQIARKIEQARAIKPISTTTELAALIKSAKPAKELKKKGHPAKQIFQAIRIEVNDELGAADASIQRAIELLALDGRISVITFHSLEDRLTKHLFKEASTADAPKGLPFIPDELKPKLELVSRKPILPSQKELMANNRAHSAKLRVARKVRK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_PILTE
Sequence: MEELQGYFEKDRSRQQPFLYPLLFQEYIYALAHDRGLNRNGSIFYEPLEVFGYDSKSSLALVKRLITRIYQQHFFLSSVNDSNQNQFVGHHHTNFFYSRFYSQMISEGFAIIVEIPFSLQLVSYLKEKEIPKSHNLRSIHSIFPFLEDKLLHFNYVSDILIPHPIHMEILVQILQCWIQDVPLLHFLRFFLHEYHNWNSFFITQNKSIYLFSKETKRLFRFLYNSYVYECEFVFVFLRKYSSYLRFTSFRTFLERRYFYGKMEHLQTEHLIIVCCDYFNGTLWSFKDPFMHYARCQGKAILVSKGTHLLMKKWKYNFVNLWQYYFHFWYQSYRIHINQLSKHSFHFLGYLSSLLKNSSTVRNQMLDNSFLIDTLTTKFDTAVPVIFLIVSLSKAQFCTVSGHPISKPIWTDLSDSGIIERFGRICRNLSHYHSGSSKKQGLYRIKYILRLSCARTLARKHKSTVRTFLQRLGSRLLEEFFTEGEQDLSLILPKAIPFPFQGSHRERIWYLDIIRINDLVNRL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YAOF_SCHPO
Sequence: MSVKIHIDRGGTFTDAIATFADESRPPIVIKLLSEDPSNYKDASIEAVRRILEIVQGKSIPRTEKLDTSCINHLRCGTTVATNALLERKGERCAFITTKGFKDGLLIGNQSRPNIFELGIRRPEVLYSKVIEVDERVTLEDYVEDPMKVKTTIDGSDPSLVVGRSGEVVRIMKKVDCDALRKDLQALYDEGFTSIAVCLAHSFTFPDHELLVGKIAEEVGFSNISLSTKLMPMIKYVPRATSATADAYLSPVVRRYLAGFQSGFLHGLKTKDNSKGVRCEFMQSDGGLVDVNKFSGLHAILSGPAGGVVGFALTSYDEDVKIPVIGFDMGGTSTDVSRYGGSYEHVFETTTAGVTIQSPQLDINTVAAGGGSRLFWKNGLFVVGPESAGAHPGPVCYRKGGYLTVTDANLLLGRLLPESFPKIFGPNEDESLDVESTRKEFEKLTAEINSGLEKERQMTADEVAFGFIKIANETMARPIRALTEAKGHDISIHRLTSFGGAGGQHCAAIAKSLGITQVLVHKYSSILSAYGMALADVVSEVQEPSSFTLDDSNTESIKKRFDSLKEEAKANLEEQGFTESQISYELFLNCRYQGTDSTLMISKPLESWDFKQSFFDKHKQEFGFIFENKDIIIDDIRIRASGKSFQSKEPSVDAQLKELKFEPVQKSLATCVKDIYFEGGRVPSEVYSLDNLPVGTIVNGPSLIVDKTQTIVVPPKAVARILHTHVVIDISHGNEYTANDSLAKASTIDPIYLSVFGSRFMAVAEQMGRALQKTSVSTNVKERLDYSCALFDAKGNLVANAPHMPVHLGSMSTCVRTQAKIHEGKLKPGDVLVTNHPSYGGTHLPDITTITPHFEGDEIMFYVAARAHHADIGGILPGSMPSSSKELSEEGATIKSEKLVVDGVFQEERMIDLLYNEPAKVEGGSGSRCLRDNLNDLKAQVSANQKGINLITSLIKEYGKNSVLRYMKAIQENAESAVRQLLLGVRERFLGEDLYAEDHMDDGSKICLRITIDEENGDAIFDFTGTTEEIYGNINAPEAVTYSAIIYCLRVLISENIPLNQGCLLPIKVIIPDNCFLKPSETAAVVGGNVLTSQRITDTILKAFQACAASQGDTNNLTFGIGGKDPETGEVKPGFGYYETICGGSGAIDGLDGTSGVHTHMTNTRITDLEVLERRYPVILRKFIIRENSGGAGKYKGGDGVIRDIEFRIPVTLSILSERRAYHPYGMKGGKDAECGKNIWIRKDILPSGEQRVRQINVGGKNTCHMQAGDHIVIMTPGGGGYGPPSERVDTVKKANGVQHFRANGTISQLQEIQHTN
What are the official names of this protein?
Uncharacterized protein C11D3.15.
What is the protein family that this protein belongs to?
Belongs to the oxoprolinase family.
Protein: PROB_LISW6
Sequence: MRESLKNSKRLVIKVGTSTLMYGNGHVNLRTIEKLAMVLSDLRNEGKEVILVSSGAIGVGCHKLQLPARPTDIPDLQAVASVGQSELMHIYSKFFGEYGQVVGQVLLTRDVTDFPISRENVMNTLESLLSRGIIPIVNENDTVAVEELEHVTKYGDNDLLSAIVARLVQADLLIMLSDIDGFYKSNPTTDPNAIMFSEINQITPEIEALAGGRGSKFGTGGMLTKLSAATYCMASHQKMILTNGKNPTIIFDIMQGAQVGTLFANKKEAFSHDRTH
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_THEM4
Sequence: MEKLEQIVNEIEQLTVAELAELVKMLEDKFGVSASAPVMAMPVAGAAAGGGAAAEEKTEFDVVLKSFGAKKINVIKVVREITGLGLKEAKDLVEKAGTPDAVIKQGVNKDEAEEIKKKLEEAGAEVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: FLIE_CUPPJ
Sequence: MTTLSPIEGMLQQLRGLAQTAAGTSSQAAAPAASGGFAGELQRSLSRINATQERAYGLSEAFELGKPGVALNDVMIELQKANVSFQTGVQVRNRLVQAYQEMMNMPV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: TAF11_SCHPO
Sequence: MKRTGSASSVPRFQRSMSYDQSNSPTAGAHAKANTASPAAEPAPSSKEKENWNRQEENDLEEDDRDDFGTAAISKVAGKPGETDDEANEKLRTKYLLESFDEEQMQRYEVFRRANLNKTNVKKLANQILNQSVTPNVAIVISGFSKVFVGEIVELARKIQDQWGDTGPLSPDHLREAYRLSRQNRRLYPQSRHVSHLFR
What is the function of this protein?
Functions as a component of the DNA-binding general transcription factor complex TFIID.  Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation.  TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (By similarity).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 11, TBP-associated factor 11.
What is the protein family that this protein belongs to?
Belongs to the TAF11 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LON1_HYDCU
Sequence: MDIDQIEFKTNVFVLALRDVVVFPGMVVPLFVGRPKSMNALNAAMKEDKQIFLVTQKNATEETPTIDNLYQTGVMANILQLLKLPDGTLKVLVEGVKRFELLALNDEENFLTGDIQQVESDEQLDNDGVVLVRTIQERFQDYAALKKKIPSEVLKSVQKITDPNRLVDTISANLKLGIEEKQTLLEILTINDRLEHILKTIETEIDLLESEQRINSRVKKKMDQTQRNFYLNTKLQAIHEELGDSSEDGVSEFTRLKEQIEQAGMTKDALKVAEDELKKLKMMSPQSPEANIIRTYIEWLVSIPWKKRSRVSKDLNKAQTILDKQHYGLEKVKERIIEYLAVQKRVNKMKGPILCLVGPPGVGKTSLARSIAEATNRKYVRMSLGGVRDEAEIRGHRKTYLGALPGRVIQKMKTAGTRNPLFLLDEIDKMARDLRGDPASALLEVLDPEQNKAFNDHYLEVDYDLSDVMFVATSNSMDIPEALLDRMEIIDLAGYTENEKLNIATQHLLPREIKEHGLKQGELEVPSDTILKIIQTYTREAGVRLLDQSLAKICRKSLKEIVTNEAKAPITVTPDTLDKYLGVAKYRFGLADETNQIGQVAGLAWTRVGGDLLRIEATAMPGKGKNTSTGQLGSVMQESTQAAMSVIRSRSKELGLPDDFYEKQDVHLHFPEGAIKKDGPSAGIAICTAIASVLTQIPVRSDVAMTGEITLRGEVLPIGGLKEKLLAAARGGIKTVLIPYENVRDLAEISDEVKEGLDIHPVQWIDEVFKIALESFPNVENDEISAISMKDAEMGKLVANKQSTKEIQKKSPKRH
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease 1, ATP-dependent protease La 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PATF_PENEN
Sequence: MKSSLWVSLAVSLIGLGPAAARNDYPGNYPSSSPPLGPTDWERTPVSVFAKVLNTQPDPDYNLLKELVTYDCTYISLTFDNPTLHGIMPWAGTHTHVGPQAFIDIFTRVGLYWDRGPFSIDHIFGDDGNVTAWGSFTATSRTLGKTVISPWAARARVNSANQIFEFQWMEDTFTTASSFGSDNSTKVFIANPEGGTAHA
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:30100914, PubMed:25625822, PubMed:30680886).  PatF catalyzes the conversion of phyllostine into neopatulin (PubMed:30680886).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units.  The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol).  These first reactions occur in the cytosol.  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI.  The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole.  PatN catalyzes then the transformation of isoepoxydon into phyllostine.  The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol.  The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM.  Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (PubMed:30680886) (Probable).
What are the official names of this protein?
Patulin biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the patF family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PRP5_KLULA
Sequence: MDQTEKLRIRQEKLAKWKKQKLNNDVTASVSVDAKEERLKKLEAWKKKKKQQDELKQKDIKLTSIKSADRDRNKRRGQCSRKRPAFGGSDSESDDENSTSTLFKPRRNDTNTHVLTKDNSKDDLDDGNDALDEYIHKLIDKDSNTNRVRLIDNISEDEDANDSSSEKTISQEEAPVDSEILFKKKGRKKIKAIDYSKVLNLITLNKCLYREPNDLGLMSEKDVEELRLSLDNIKISGKDCPKPVTKWSQLGLSSEIMDLISNELQFVTLTPIQCQAIPAIMSGRDVIGISKTGSGKTVAFLLPLVRQIKAQPPLAPDETGPIGLILTPTRELAVQIQEEALKFCKGSGISSICCVGGSELKQQINELKRGVDIIVATPGRFIDLMTLNSGHLLSPTRISFVVMDEADRLFDLGFGPQVNQIMGCIRPDKQCVLFSATFPSKLKHFASRTLKNPIQITINSKSLINENIQQRVQIFDEEHVKFEFLLKRLSDRLALHRGEDEKTIIFVGSQQLCDLLYDELLLNGITTFPIHAGKPSAERLRNLQKFKETDNGILICTEVLSRGLNVPEVSLVIIYNAAKTIAQYVHTVGRTGRGTNNGVALSFVMVDELASAYILVKCMKENELSSVPMVVYQKLKEMNDEFSSGLKTGKYRLIQGFGGKGLDHLDELNEAKQSQEYTDYGVVENEEDVTEEESGATKMEYTRGKREEGHSTTYFAHININDLPQLARWEATKTETVSNIKQETGCNFESKGSFYPEGKGPKNDTDDPKLYLIVEGAEESDVTMALELLNTKVKEGIRKAAVKDIQSGKYRM
What is the function of this protein?
ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing.  Catalyzes an ATP-dependent conformational change of U2 snRNP.  Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
What are the official names of this protein?
Pre-mRNA-processing ATP-dependent RNA helicase PRP5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RADA_METMA
Sequence: MSEIALEELPGVGPATAEKLKEAGFNTIEAVAVASPSELATTAEIGESTAAKIINAARQAADIGGFETGDLVLERRKLVGKLTTGCTEFDEMMGGGIETQAITELYGEFGSGKTQVAHQLAVNVQMDREHGGLGGSVIIIDTENTFRPERITQMVNGLSEKYGMELNPEEFLQNIHVARAYNSNHQILLVDSAVDLANELKEMGKPVRLLIVDSLMAHFRAEYVGRGTLADRQQKLNKHMHGLLRFGDLFNACVVVTNQVMAKPDAFFGDPTRPIGGHIVGHTATFRLYLRKSKGEKRIIRLVDSPSLPEGEAVVAVTTAGLTDQ
What is the function of this protein?
Involved in DNA repair and in homologous recombination.  Binds and assemble on single-stranded DNA to form a nucleoprotein filament.  Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
What are the official names of this protein?
DNA repair and recombination protein RadA.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RecA-like protein family.
Protein: VKTRE_DENAN
Sequence: LQHRTFCKLPAEPGPCKASIPAFYYNWAAKKCQLFHYGGCKGNANRFSTIEKCRRACVG
What is the function of this protein?
Serine protease inhibitor that inhibits trypsin.
What are the official names of this protein?
Kunitz-type serine protease inhibitor long epsilon-dendrotoxin Arg55.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL21_VARPS
Sequence: MYAVIKTGGKQYRVASGEKIKVEQIAADVGQEIVIDQVLAVGNGSEIKIGTPLVSGATVTVTVLSHGKHDKVGIFKMRRRKHYQKRQGHRQQFTELQIGAIAG
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: PETN_LOLPR
Sequence: MDIVSLAWAALMVVFTFSLSLVVWGRSGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: KHSE_AGRFC
Sequence: MAVYTDITEDELRNFLTQYDVGSLTSYKGIAEGVENSNFLLHTTKDPLILTLYEKRVEKNDLPFFLGLMQHLAAKGLSCPLPLPRKDGELLGELSGRPAALISFLEGMWLRKPEAKHCREVGKALAAMHLASEGFEIKRPNALSVDGWKVLWDKSEERADEVEKGLREEIRPEIDYLAAHWPKDLPAGVIHADLFQDNVFFLGDELSGLIDFYFACNDLLAYDVSICLNAWCFEKDGAYNVTKGKALLEGYQSVRPLSEAELEALPLLSRGSALRFFLTRLYDWLTTPAGALVVKKDPLEYLRKLRFHRTIANVAEYGLAGE
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.