PharMolix/UniProtQA huggingface dataset:
Protein: CLD10_HUMAN
Sequence: MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGTVITTATYWANLWKACVTDSTGVSNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKAKAKIACLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGAALFIGWAGASLCIIGGVIFCFSISDNNKTPRYTYNGATSVMSSRTKYHGGEDFKTTNPSKQFDKNAYV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.  Involved in the regulation of paracellular epithelia permeability to ions in multiple organs.  It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions.  In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597).
What are the official names of this protein?
Claudin-10, Oligodendrocyte-specific protein-like, OSP-like.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: GP158_BOVIN
Sequence: MGVMAYPFLFCLLLVHFGLGAIGASREAPSRPDPPRERTLRAKQHAQQPARASASDPSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGDSHKLKRANCSSRYELAGLPGKSPALASSHPSLHGALDTLTHATNFLNMMLQSNKSREQNLQDDLEWYQALVRSLLEGEPSISRAAITFSTESLSAPAPQVFLQATREESRILLQDLSSSAHHLANATLETEWFHGLRRKWRTHLHRRGSNQGPRGLGHSWRRRDGLSGDKSHVKWSPPYLECENGSYKPGWLVTLSAAFYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYQCICKAGFYHPRDFSFNNFQRRGPDHHFVESAKDVSEEVHVCLPCSEGCPYCADDSPCFVQEDKYLRLAIISFQALCMLLDFLSMLVVYRFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWVRLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWFLVGWTSSVCQNLERHISLIGQGRTSDHLIFSMCLVERWDYMTAAAEFLFLLWGVYLCYAVRTVPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKDGGEHGSAKGSSAGRKNPQETAGGSGKPKEESLRSRVFSLKKSHSTYEHVREQPGGPGSPPAQSREEEEATDNSVLGSPVGANRPRPLQEDSQAVSTESVPLVCKSASAHNLSSEKKPGPTRTSVLQKSLSVIASAKEKTLGLAGKTQAACVEERAKAQKALPRERETNRKYSNSDNAETQDSAPPNSSHSEEPRKPQKLGIMKQQRANPTTANSDLSPGATHMKDNFDIGEVCPWEIYDLAPGPGPLESKVQKHVSIAASEMERNPTFSLKEKSHPKPKAADLCQQSNPKSVDKAEVCPWESQGQSLFEEEKYLMSKTQVPLGRAQGENSGQHCATGVCAGQCEELPPKAVASKVENENLNQLGEQEKKTSSSERNVPDSHNSSNNFQPPLMSRAEVCPWEFETPDKPNAERSVAFPASSALSANKIAGPRNEEVRLARKV
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 158.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FADI_SHEB9
Sequence: MSDRQQVTNAKGERIAIVAGLRTPFAKQATAFHGVSALDMGKMVVNELLARSELDPKLIEQLVYGQVVQMPAAPNIAREIVLGTGMNVSTDAYSVTRACATSFQSAVNVAESIMTGNIEIGIAGGADSSSVLPIGVSKKLAHALVDLNKARSFGQKLQIFRRLGIKDLLPVPPAVAEYSTGLSMGQTAEQMAKTYNISRADQDALAHRSHTLASETWASGHLRDEVMVAHVPPYKQFIDRDNNIRENSVLESYAKLRPAFDKQHGTVTAANSTPLTDGASAIILMSEGRAKALGYQPIGYIKSYAFSAIDVWQDMLMGPSYATPLALKRAGMELEDLTLIEMHEAFAAQTLANMQMFASKKFAEEKLGRNRAIGEIDMSKFNVLGGSLAYGHPFAATGTRLITQVCRELKRRGGGTGLTTACAAGGLGVAMIVEVE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_NITEC
Sequence: MNIRDLGKVAVLLGGRSAEREISLKSGHAVLAALQRSQVDAHAFDPVGQPLEDLLKQGFDRAFIALHGRYGEDGSVQGALELMDLPYTGSGILASALAMDKWRTKMIWQAAGISTPDYVMLDADSNFQEVTDRLGLPLIIKPAREGSTIGLNKVDYAQDMQSAYQTAAQHDSLVIAEQFIQGIELTAAILDDVPLPLVRIDVTEGLYDYQAKYFSESTRYTCPSGLSKILTTRIQEQALYAHRILGCTGWSRVDLILDKNGQPFFLEANTSPGMTNHSLVPMAAQAAGISFDELVIQILELSCEYA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIAS_SCHMA
Sequence: MGLLLPRGSYVFPVLASVSAATKRRAEWSYIKINITHSYSSNDKSSEFEEDNPTQKLSPEFQKAIAHGPSLSEFIKLSNNNQSTKEDFFSSPSSVNKSGKSLRLPEWLKTEIPCGGSVARLQKQLRSLNLHTVCEEARCPNISECWTAGKSTAATATIMIMGDTCTRGCRFCSVKTSPNPPPLDPDEPVNTAEAISKWDVDYIVITSVDRDDLGDGGARHIAKTIRQIKVRKPSIIVECLVPDFRGCTDSIHTVVRASPEVYAHNIETVESLQRVVRDHRAGYIQSLRSLETAKERSNRLVSSGDADFLVVTKSSIMLGLGEKEKEVMIALKDLRQAGVDCVTIGQYVQPTKRHLKVKEYIHPDKFDYWAKIGNDLGFLYTASGPLVRSSYRAGEYYIKHIIDQRKRKNI
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PGSA_SODGM
Sequence: MQLNIPTWLTLFRVVMIPFFVLAFYLPFKWAPLCCALIFVLAAVTDWFDGFLARRWKQTTRFGAFLDPVADKVMVAMALVLVAEHFHSWWITLPAATMIAREIIISALREWMAEIGKRSSVAVSWIGKVKTTAQMLALVTLLWRPDDIVSGIGIAALYVAAVLTFWSMFQYLYAARHDLFEH
What is the function of this protein?
This protein catalyzes the committed step to the synthesis of the acidic phospholipids.
What are the official names of this protein?
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, Phosphatidylglycerophosphate synthase, PGP synthase.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LRIF1_MOUSE
Sequence: MSNSLQSVILKTAEEKSGSRCISGCMYQVVPTIGSDGKKLLQLLPISKSSGNLIPVVQSPVMSHGLKANTEKPVQVTFQTQISSSSTSASVQLPVFQPANTTKCFFTGAIDTTGKDRVTSVRTGNFTPPVSNIQNHGVKIHKLTRQTFTIPPSTQNDSSHFIFNTPSLLPNVNSSILPSGNHLKIPAHAEVKSVLASSLPPLVQQKILGTATTSTSGTVEASQIPTVVYVHPVNSVKFVVTKKTQTIYPKPVTFNTLQIPPNVATETQLKGGQHPQAAPVNSIFQEYLQPGIPCIIPVKSSNNVATKVLNTFVGRKNLGDNTIDTPLLNTNSSGRTHSVSEPIKDNALIMFNGKVWLNEKGTCGLPSKIDQQNSVSSDIPLKDSSQLVSSSIVTEISREILNSVLVKSKSFQLKTKSLSNSQLASMANLRAEKNEKVERPSFSVTNPHTMNQSTHCLKQSKTVFINPVFPDGFRTGQNAPRKGNLVQNIEKICSSVDAATVTSQQCVFRDQESQTQYEMASIVKKEIQEKGNNKKYSQGSHTNIKASCLKNDAEFKKLFGLTKDLRVCLTRIPDHLSSGKSFNSFNSLMKSSSYKDANIVVKKEEKKQSFSKKRKAETMKMGNTKKIKIENADDTVMSIMNGTDVASSQPLSSILPTSDISQHNIVTSHSTTREDKRTEAEHCSHEKQEKGTLSSSTSFEQSTFLNKNFMEDIFPVTPPELEETIRDEKIRRLKQILREKEAALEELRKKMYQKQ
What is the function of this protein?
Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin.  Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases.
What are the official names of this protein?
Ligand-dependent nuclear receptor-interacting factor 1.
What is the protein family that this protein belongs to?
Belongs to the LRIF1 family.
What are the subcellular locations of this protein?
Chromosome. Nucleus matrix. Note=Localizes to Barr body; recruited by SMCHD1.
Protein: FANCL_HUMAN
Sequence: MAVTEASLLRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVLPEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQHSPDLMSFMMELKMLLEVALKNRQELYALPPPPQFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAEDASGREHLITLKLKAKYPAESPDYFVDFPVPFCASWTPQSSLISIYSQFLAAIESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEKSDFTMDCGICYAYQLDGTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNIIFGECPYCSKPITLKMSGRKH
What is the function of this protein?
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026).  Also mediates monoubiquitination of FANCI (PubMed:19589784).  May stimulate the ubiquitin release from UBE2W.  May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
What are the official names of this protein?
E3 ubiquitin-protein ligase FANCL, Fanconi anemia group L protein, Fanconi anemia-associated polypeptide of 43 kDa, FAAP43, RING-type E3 ubiquitin transferase FANCL.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRUB_BRUA2
Sequence: MARRGKKKGRPISGWVIFDKPKGMGSTEAVSKIKWLFSAEKAGHAGTLDPLASGMLPIALGEATKTVPYVMDGTKVYRFTVTWGEERSTDDLEGQPTKTSDKRPSREEVEALLPDYTGVISQVPPQFSAIKIDGERAYDLAREGETVEIPAREVEIDRLEIVGFPDADRTEFEVECSKGTYVRSLARDMGRDLGCYGHISDLRRVEVAPFTDEDMVTLAKLEAVWPPLPPKDEDGNVIEPAPRRDFSALDALVIDTGAALDCLPQVPLSDDQAQRVRLGNPVILRGRDAPLEADEACVTTRGKLLAIGYIEHGQFKPKRVFTAG
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: URK_STRPI
Sequence: MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYKDQSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQEPQDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQYLGVVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GVPA_HALMT
Sequence: MVQPDSSSLAEVLDRVLDKGVVVDVWARISLVGIEILTVEARVVAASVDTFLHYAEEIAKIEQAELTAGAEAAPTPEA
What is the function of this protein?
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms.  They allow the positioning of the organism at the favorable depth for growth.  GvpA type proteins form the essential core of the structure.
What are the official names of this protein?
Gas vesicle structural protein, GVP, VAC.
What is the protein family that this protein belongs to?
Belongs to the gas vesicle protein type A family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle membrane.
Protein: CYSZ_ECOLI
Sequence: MVSSFTSAPRSGFYYFAQGWKLVSQPGIRRFVILPLLVNILLMGGAFWWLFTQLDVWIPTLMSYVPDWLQWLSYLLWPLAVISVLLVFGYFFSTIANWIAAPFNGLLAEQLEARLTGATPPDTGIFGIMKDVPRIMKREWQKFAWYLPRAIVLLILYFIPGIGQTVAPVLWFLFSAWMLAIQYCDYPFDNHKVPFKEMRTALRTRKITNMQFGALTSLFTMIPLLNLFIMPVAVCGATAMWVDCYRDKHAMWR
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.  Does not transport thiosulfate.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TAL_KOCRD
Sequence: MTTPTQKLSDAGVSIWLDDLSRQRLTSGNLQKLIDTENVVGVTTNPTIFAAALADGESYREQVAELAAADTSVDDAVFRITTDDVRDACDLFAPIAEATQGVDGRVSIEVDPRLAQDADATSAMAQKLSQTIDRPNALIKIPATEKGLPSIAATVAEGISVNVTLIFSLERYRGVINAYMEGLERALENGKDLSTIHSVASFFVSRVDTEIDKRLDAVGSSEATALKGKAGLANARLAYQVYEQSLDTERWKRLAAAGANPQRPLWASTGVKDPSLPDTLYVTELVAPNTVNTMPEKTLDATFDHAEVTGDTVTGTYEQSAEVLDAIAEQGVSYQEVVAQLETEGLQKFDASWEELLSTVRAALDAAR
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBL_OENBI
Sequence: MTQSNPNEQDVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: UPE23_UPEIN
Sequence: GFFDLAKKVVGGIRNALGI
What is the function of this protein?
Shows a medium antibacterial activity against B. cereus, L. mesenteriodes and S. uberis.
What are the official names of this protein?
Uperin-2.3.
What are the subcellular locations of this protein?
Secreted.
Protein: KAD_HALSA
Sequence: MSHPNVLLLGAPGAGKGTQSRRLVDEFGVEHVTTGDALRANKTKDITHLDVEYDTPGAYMDAGELVPDAVVNEIVKTALDDADGYVLDGYPRNESQTEYLDSITDLDVVLYLDVDEDELVGRLTGRRVCEDCGATFHVSFNQPETEGVCDACGGSLYQREDDTEETARERITVYEENTAPVVEYFREQGVLAEVDGERTPDEVWTDVAAAVDERTA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_VARPS
Sequence: MKIAQEIRAGNVIMHGKDPMVVLKTEYSRGGRNSATVRMKLKSLIANFNTEVVFKADDKIDQIVLDKKECTYSYFADPMYVCMDTEYNQYEVEAENMGDALNYLEDGMPVEVVFYDGKAISVELPTSVEREITWTEPAVKGDTSGKVLKPAKIATGFEVPVPLFVSQGDKIEIDTRTGEYRKRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SX3_OPHHA
Sequence: MKTLLLTLVVVTIVCLDLGYSLICFNQETYRPETTTTCPDGEDTCYSTFWNDHRGVKIERGCGCPRVNPGISIICCKTDKCNN
What are the official names of this protein?
Weak neurotoxin WNTX33, Three-finger toxin, 3FTx.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PPNP_CELJU
Sequence: MFKVNEYFDGAVKSIAFQTETLPATVGVMAKGSYEFGTSQKEYMTVVSGSLTVVLPGSDKAETFTQGQTFIVEANQRFNVTADVESSYLCCYE
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: RS15_RICPR
Sequence: MSITTERKQQLIKEYAITENDTGSTAVQCAILTERINNLTEHFKSNHKDHTSRRGLLILVGRRRRLLNYIKKNNVSEYLDLISKLGIRKIK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: TGA1B_TOBAC
Sequence: EFCDFSGNQAAGGVMVMDTSSPELRQSSSGSDVLNATSSTSSHQVSGDVAGYLNVPSPESNGSNHEGSRESANDNKGLGDARVLNCHSPESQGSGNYGSNVSEGLNYPSDSNKSVHSSPNFENNSIKNGAVEEKIKLEGVNANISKCSSLLKRKKSSEDSNNINIHQKLTNVALSDNVNNDEDEKKRARLVRNRESAQLSRQRKKHYVEELEDKVRIMHSTIQDLNAKVAYIIAENATLKTQ
What is the function of this protein?
Binds specifically to the DNA sequence 5'-TGACG-3'.
What are the official names of this protein?
TGACG-sequence-specific DNA-binding protein TGA-1B, TGA1b, HSBF.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YACG_METCA
Sequence: MSMSHIYTVVRCPRCGKPVPWNETQRFRPFCSERCRLIDLGSWANEDYAIPGEPIDPAEPSEDRNGAEGPPTD
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: MSRB_SALTY
Sequence: MANQPSAEELKKKLSEMQFYVTQDRGTEPPFTGRLLHNKRDGVYHCLVCDTPLFHSHTKYDSGCGWPSFYQPVSEEAIRYIDDFSHGMQRVEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLAFSDEKNGDQLKG
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: PA2A2_HELSU
Sequence: GAFIMPGTLWCGAGNAASDYSQLGTEKDTDMCCRDHDHCSDTMAALEYKHGMRNYRPHTVSHCDCDNQFRSCLMNVKDRTADLVGMTYFTVLKISCFELEEGEGCVDNNFSQQCTKSEIMPVAKLVSAAPYQAQAETQSGEG
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 PA4, PLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group III subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TYSY_HAEIN
Sequence: MKQYLELCRRIVSEGEWVANERTGKHCLTVINADLEYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRALGTKTWDANANENAAWLANPHRRGVDDMGRVYGVQGRAWRKPNGETIDQLRKIVNNLTKGIDDRGEILTFFNPGEFDLGCLRPCMHTHTFSLVGDTLHLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIVNAHIYEDQLELMRDVQLKREPFPLPKLEINPDIKTLEDLETWVTMDDFKVVGYQSHEPIKYPFSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCIB_LACLC
Sequence: MKKKVDTEKQITSWASDLASKNETKVQEKLILSSYIQDIENHVYFPKAMISLEKKLRDQNNICALSKEVNQFYFKVVEVNQRKSWMVGLIV
What is the function of this protein?
Imparts immunity to lactococcin-B to naturally sensitive host strains.
What are the official names of this protein?
Lactococcin-B immunity protein.
Protein: ZAPB_SHESA
Sequence: MSLELLSKLETKIQATLETIELLKMELEEEKQKTSALNEQNQQLSEQNQQLQQELASWNDKVTGLVGLLNSEI
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: M1_I71A2
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: PNP_THEAB
Sequence: MQFREWTKELFGRKMIVQHGKVAKQSAGSVWVQFGDSVVLATANISDRTIEGVDFVPLTVEYQEKFYAAGKIPGGFIKREGKPSESAILSARLIDRPIRPLFPKYLRNDVQLIVTVLSVDGNTPPDVTGIIAASLALNISKIPFEGIVAGVRLGYVDGKFVVFPTEEQLEKSRLDIVVAGSKDAITMVEGEAKEVTEEEMVNALMVAHDAIKQIIEFEEEILSQFDVQKMEIEEPKPNETLIGKFEEMISEEELRDKLLIKEKLERSAKLKEYRDQILEKIFEDVEMEDDEKILQESLLKEYFDERTKKLMRKIIIEEGIRADGRKVDEIRPITCEVGVLPRTHGSALFTRGETQSLGIVTLGAPMEEQIVDTIMEEGTKRFILHYNFPPFSVGEVKPLRGPGRREIGHGHLAERALKAVVPSEEEFPYVVRVVSEILESNGSSSMATVCSGSLALMDAGVPIRTHVAGVAMGLIIEDGQEVVLTDIQGLEDHWGDMDFKVAGTRNGITAFQMDCKVAGVGEELLKRALQQAKEARMKILDIMFNTIEKPRESLSPYAPLIVTIEIDPMKVGELIGPGGKVIKSIIKEYDVEISIDDTTGKVSIYGKDQKKVNEAIEYIKTITKDIEVGDVFEGKITRIEPYGIFVELMPGKIGLAHSSKLGEDSKNFKEKYKIGDTIKVIVVNIDENGRIQLGKTN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4086_XANC8
Sequence: MHAYVYKSQRKQDTFVYLATRDDFSVIPADVQARLAPFAFVLDVALTPERRLAQADADTVRAALASHGFYLQLPKTVVLAGECDYD
What are the official names of this protein?
YcgL domain-containing protein XC_4086.