PharMolix/UniProtQA huggingface dataset:
Protein: CARB_CLAMS
Sequence: MPKRDDINSVLVIGSGPIVIGQAAEFDYSGTQACRVLREEGVRVILVNSNPATIMTDPGFADATYIEPITSEVLEKIIIKERPDAVLPTLGGQTALNAAIRLDELGILAKHGVELIGAKVEAIQKGEDRQLFKDLVIESGADVARSHVAKTLEQAVEFAEDLGYPLVIRPSFTMGGLGSGFAHTRQELERMVADGLQSSPTTEVLLEESILGWKEYELELMRDTADNTVVVCSIENVDPVGVHTGDSITVAPALTLTDREYQHMRDIGIDIIRRVGVDTGGCNIQFAVDPTNGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYRLDEIPNDITKVTPASFEPTLDYVVVKVPRFAFEKFPAADAELTTTMKSVGEAMAIGRNYSTALQKALRSLEKRGSSFHWGAESRSVEELLETSRIPTDGRIVTVQQALRAGATPEQVFDATKIDPWFIDQIVLINEVADAVRDADELDAPTLREAKDHGFSDAQIAEIRGIGEQEVRDARHAAGIRPVFKTVDTCAGEFPALTPYHYSSYDSETEIVPSDRRKVIILGSGPNRIGQGIEFDYSCVHASFALADAGFETIMINCNPETVSTDYDTSDRLYFEPLTLEDVLEIVHVEQQAGELVGVVVQLGGQTALGLAKGLEAAGVPILGTSPSAIDLAEERGLFSGILDAAGLVAPRNGTAVAIDEAVVVAEEIGYPVLVRPSYVLGGRGMEIVFDTATLHDYFLRMADQGIIGEGKPLLIDRFLDDAIEIDIDAIYDGTELYVGGVMEHIEEAGIHSGDSSCTLPPVTLGRGQIQQVVDATRAIAEGVGVRGLLNVQFAIGAGVLYVLEANPRASRTVPFVSKALGIPLAKAASLVMVGTSIAELKASGLLPERDGSDVPMDSPVAVKEAVLPFKRFRTKDGLIVDSVLGPEMRSTGEVMGIDRDFPRAFAKSQEAAFGGLPLSGTVFVSVADRDKRSIVLPVLRLQQLGFEVLATAGTAEILSRNGIQARVVRKYSEEPAAGDSPSIVDLINRDEVDVVINTPSGRTARADGYEIRAAAVAADKPLFTTIAQLTAAVASFDAIRAGFDVTSLQDYAIAREARR
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: RL27_DESDA
Sequence: MAQKKAGGSSRNGRDSVGQRRGVKRFGGQRVLAGNILVRQLGTTVHPGVNVGMGRDFTLFAKIDGVVRFEKYIRKRRVLTRVHVEAAAS
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: ATPF_STRP1
Sequence: MSITFGELVGNFILVTGSVIVLLLLIKKFAWGAIESILQTRSQQISRDIDQAEQSRLSAQQLEAKSQANLDASRLQASKIISDAKEIGQLQGDKLVAEATDEAKRLKEKALTDIEQSKSDAISAVKTEMSDLTVLLAEKIMGANLDKTAQSQLIDSYLDDLGEA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RLMN_BURP0
Sequence: MAGETIVNLLDLDAEGLVAYCGSLGEKAFRAKQLQRWIHQYNAADFDGMTDLAKSLREKLKGRAVIGTPDILSDHVSADGTRKWLINVGNGNAVETVFIPEETRGTLCVSSQAGCAVNCRFCSTGKQGFSRNLSTGEIVGQLRMAEFALRASLGRAPGPNGKAERVITNVVMMGMGEPLLNYSAVVPAMRLMLDDNAYGLSRRRVTLSTSGVVPMMDRLGAELPVALAVSLHAPNDALRDELVPLNKKHPLRELMAACQRYLKVAPRDFITFEYCMLDGVNDTEAHARELLAVTRDVPCKFNLIPFNPFPESGLVRSKTEQIKRFAQVLIDAGVVTTIRKTRGDDIDAACGQLAGAVKDRTRLAERTGASKIIEVRAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAND_CLOB6
Sequence: MTITMLKSKIHRATVTEANLNYVGSITIDKNLMDKANILEYEKVQIVDIDNGNRFETYVIAGEKHSGVICLNGAAARMVQKGDKIIIMSYCDLTIDEANKFNPTVLFVDNKNNIEKLTNYEKHGEII
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3184_XANCP
Sequence: MRIEVWQGDITQLDVDVIVNAANESLLGGGGVDGAIHRAAGPRLLEACEALPEVRPGVRCPTGEIRITDGFDLKARHIFHTVGPVWRDGKHNEPEQLANCYWQSLKLAEQMMLHSIAFPAISCGIYGYPLYQAARIAVTETRDWQRSHKVPKHIVLVAYNEATYKAYHQALATQETAAA
What are the official names of this protein?
Macro domain-containing protein XCC3184.
Protein: RECR_PHOPR
Sequence: MRTSHLLEQLMEALRCLPGVGPKSAQRMAFNLLQRNRQGGLQLADALNRAMTDIGHCRDCRTFTEDDICAVCANPRRQENGQICVVESPADIVAVESTGQFSGRYFVLMGHLSPLDGIGPSDIGLDTLEFRLQKETIAELILATNPTVEGEATAHYIAELCHEYGVPATRIAHGVPVGGELELVDGTTLSHSLAGRQKLNLY
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: GRAS_STAA2
Sequence: MNNLKWVAYFLKSRMNWIFWILFLNLLMLGISLIDYDFPIDSLFYIVSLNLSLTMIFLILTYFKEVKLYKHFDKDKEIEEIKHKDLAETPFQRHTVDYLYRQISAHKEKVVEQQLQLNMHEQTITEFVHDIKTPVTAMKLLIDQEKNQERKQALLYEWSRINSMLDTQLYITRLESQRKDMYFDYVSLKRMVIDEIQLTRHISQVKGIGFDVDFKVDDYVYTDTKWCRMIIRQILSNALKYSENFNIEIGTELNDQHVSLYIKDYGRGISKKDMPRIFERGFTSTANRNETTSSGMGLYLVNSVKDQLGIHLQVTSTVGKGTTVRLIFPLQNEIVERMSEVTNLSF
What is the function of this protein?
Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs).  Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX.  In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis.  Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis.
What are the official names of this protein?
Sensor protein kinase GraS, Glycopeptide resistance-associated protein S.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MSRQ_SALA4
Sequence: MRLTAKQITWLKVCLHLAGFLPLLWLFWAINHGGLSADPVKDIQHFTGRTALKFLLATLLVSPLARYAKQPLLIRTRRLLGLWCFVWATLHLTSYALLELGIHNLALLGSELISRPYLTLGIISWLVLLALTLTSTQFAQRKLGKRWQTLHNVVYLVAILAPIHYLWSVKILSPQPVIYAALALALLALRYRKFRQWWR
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PRS57_MOUSE
Sequence: MPSSTAMVPGTRGGWHCLVLTTAAALTQLMWLPGCCGSYIVGGHEVTPHSRPYMASVSFEGHHYCGGFLIHTHWVVSAAHCFSDRDPSMGLVVLGAHALLAPEPTQQTFSIAAAVSHPDFQPATQANDICLLRLNGSAVLGPAVRLLRLPRRNAKPPAAGTRCHVSGWGFVSDFEEPPPGLMEVEVRILDLSVCNSSWQGQLNPAMLCTHSGDRRRRGFCSADSGGPLVCGRRAHGLVSFSGLWCGDPKTPDVYTQVSAFVTWIWDVVRASSSPGSTGRSVRAV
What is the function of this protein?
Serine protease that cleaves preferentially after Arg residues.  Can also cleave after citrulline (deimidated arginine) and methylarginine residues.
What are the official names of this protein?
Serine protease 57, Neutrophil serine protease 4, NSP4, Serine protease 1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cytoplasmic granule lumen. Secreted. Note=Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils.
Protein: APN1_CAEEL
Sequence: MANKKVTFREDVKSPAIRKLKQKLTPLKIKKGRGKIQKHIQKTLQKMKEEEESENQSPGTTVEETLTEENISTDKEETSKLENKPKKTRKTSGETIAQKKSRETVGVEVLKTSEGSSKMLGFHVSAAGGLEQAIYNARAEGCRSFAMFVRNQRTWNHKPMSEEVVENWWKAVRETNFPLDQIVPHGSYLMNAGSPEAEKLEKSRLAMLDECQRAEKLGITMYNFHPGSTVGKCEKEECMTTIAETIDFVVEKTENIILVLETMAGQGNSIGGTFEELKFIIDKVKVKSRVGVCIDTCHIFAGGYDIRTQKAYEEVMKNFGEVVGWNYLKAIHINDSKGDVGSKLDRHEHIGQGKIGKAAFELLMNDNRLDGIPMILETPEGKYPEEMMIMYNMDKR
What are the official names of this protein?
Apurinic-apyrimidinic endonuclease, AP endonuclease.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPX_WOLPM
Sequence: MDNNNDLHYCSFCNKAQDEVDKLITNSSDGLKVFICNECIELSHKAISQKKDRSFNSDRISDMKLLLKKPEDIKNFLSKHVVGQKHAQHVLSVAMYNHCQSMVQFHAISDIEIEKSNIMLIGPTGSGKTLLAKTLAKVSDVPFAMADATTLTEAGYVGDDVESVLSRLLQAANYDVVKAQRGIVFIDEIDKITRKSEGTSITRDVSGEGVQQALLKIMEGTVAYVPPQGGRKHPQQEFIQVDTSNILFICGGAFEGLDKIIEARKKGTSVGFGADISQSKEQKKKNALHDVQPEDLIKFGLIPEFVGRVPITAVLDELDHEDLIHVLTEPRNALIKQYKALLAFSKVNLEFSDEAISAIAKKAISYKTGARMLRAILESLLLDIMYTSGNGGFEGSTIVITKKMVELGKATVNHNNNGNVITVND
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: SYDND_METAC
Sequence: MSLANLRTHYTAEVKPESVDNGQKITLAGWIHEVRDLGGICFVVLRDREGKAQVTLVKKKIDKELFDAARRLIRESVISVTGSVKFEEKAPNGYELLPEEIKVLNVAGSPLPMDTTGKVEAELDTRLDSRFIDLRRAETTAVFKIRHEALQAIREYFVKNKFIETATPKVVATATEGGTALFPITYFDREAFLNQSPQLFKQILMGGGFDRVFEIGPIFRAEEHDTRRHLNEATSIDVEVSFADHFDVMEILENLVAHIYTRVIENCKASLEILGVELKVPKTPFLKLTYDEVIEIVNSRCEEKMHWGDDLGTLGEHTVGNYVYETTGESHYFIIDWPTEIKPFYAMPYEDRPEFSKSFDMMHRTMELSSGAQRIHISELLKSRIESQGLNPDGFEFYLKAFEYGMPPHAGWGMGCERFVMTMLGTENIRDTVLFPRDRRRLSP
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARF_HUMAN
Sequence: MVRRFLVTLRIRRACGPPRVRVFVVHIPRLTGEWAAPGAPAAVALVLMLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGRGAAGRARCLGPSARGPG
What is the function of this protein?
May be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.
What are the official names of this protein?
Tumor suppressor ARF, Alternative reading frame, ARF, Cyclin-dependent kinase inhibitor 2A, p14ARF.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. SUBCELLULAR LOCATION: [Isoform smARF]: Mitochondrion.
Protein: PG173_MONPV
Sequence: MDKIKITIDSKIGNVVTISYNLEKITIDVTPKKKKEKDVLLAQSVAVEEAKDVKVEEKNIIDIEDDDDMDIENT
What is the function of this protein?
Plays a role in the inhibition of host protein synthesis.  Specifically, inhibits the initiation of cap-dependent and cap-independent translation.  In turn, affects the outcome of infection by decreasing recruitment of inflammatory leukocytes and reducing the memory CD8+ T-cell response.
What are the official names of this protein?
Protein OPG173.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG173 protein family.
Protein: CAPON_MOUSE
Sequence: MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLTGAERVSTAAAEETDIDAVEVPLPGNDILEFSRGVTDLDAVGKDGGSHIDSTVSPHPQEPMLTASPRMLLPSSSSKPPGLGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQNTMGSQDSLLEITFRSGALPVLCESTTPKPEDLHSPLLGAGLADFAHPAGSPLGRHDCLVKLECFRFLPPEDTQPMMAQGEPLLGGLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQELGDSLDDEIAV
What is the function of this protein?
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1.  The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level.  Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1.  Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).  In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862).
What are the official names of this protein?
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, Nitric oxide synthase 1 adaptor protein.
What are the subcellular locations of this protein?
Cell projection, filopodium. Cell projection, podosome.
Protein: HIS6_LEPBP
Sequence: MDELTKRVIPCLDIKGGRVVKGVQFVNLIDAGDPVSCAVAYEENKADELCFLDITASSDKRDILLHLVEEVANKLFIPFTVGGGIRTIEDVKAVLNKGADKVSINTSAFQNPKLLKDASEIYGSQCIVCAIDVKFHPERKRYEVYLNGGRAETGREALDWGKEAHEMGAGEILLTSMDKDGTKDGFDINLMKSFTSNLTIPIIASGGAGNPEHMAEVILRGGADAVLAASIFHFGEFSIQETKQTMKEMGIKVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACH1_SCHPO
Sequence: MPSLLSSRIRNAEFAKKIVTDPAKLVPYFKNGDYVGWSGFTGVGYPKMIPNALARHVEENNLQGKLRFKLFVGASGGADTECKWAELNMIERRCPHQVGKPISKGINSGRIQFFDKHLSMFPQDLLYGYYTRNRESNTIDTAIIEATAITEDGGIVPGASVGASPELMQLAEKIIIEVNTAIPSFEGLHDIVEIPNPPHRTPININRVDDRIGKPYIKVDPKKVIGIVEADYGDITCANSPQDETSQAIAGHLVDFFHHEVSVGRLPKNLHPLQSGIGNIANAIIGGLAHSPFKDLEVWTEVLQDTFLPLFDSEKLRFATATSTRFSPQGFEKFYSNYDYYKERILLRPQVISNHPEIIRRLGCIAMNTPVEADIYAHANSTNVLGSRMLNGLGGSADFLRNAKLSIMHTPSVRPSKKDPTGITCIVPMATHVDQTEHDLDILVTEQGLADLRGLSPTERAREVIDKCAHPDYKPLLREYFDIAENYCLARGAGHEPHILANAFKMQLNLLEKGTMKIDHW
What is the function of this protein?
Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.
What are the official names of this protein?
Acetyl-CoA hydrolase, Acetyl-CoA deacylase, Acetyl-CoA acylase.
What is the protein family that this protein belongs to?
Belongs to the acetyl-CoA hydrolase/transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBED_SHIBS
Sequence: MKTKLNELLEFPTPFTYKVMGQALPELVDQVVEVVQRHAPGDYTPTVKPSSKGNYHSVSITINATHIEQVETLYEELGKIDIVRMVL
What are the official names of this protein?
UPF0250 protein YbeD.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: AMBN_RAT
Sequence: MSASKIPLFKMKGLLLFLSLVKMSLAVPAFPQQPGAQGMAPPGMASLSLETMRQLGSLQGLNALSQYSRLGFGKALNSLWLHGLLPPHNSFPWIGPREHETQQYEYSLPVHPPPLPSQPSLQPHQPGLKPFLQPTAATGVQVTPQKPGPHPPMHPGQLPLQEGELIAPDEPQVAPSENPPTPEVPIMDFADPQFPTVFQIAHSLSRGPMAHNKVPTFYPGMFYMSYGANQLNAPARIGFMSSEEMPGERGSPMAYGTLFPGYGGFRQTLRGLNQNSPKGGDFTVEVDSPVSVTKGPEKGEGPEGSPLQEASPDKGENPALLSQMAPGAHAGLLAFPNDHIPNMARGPAGQRLLGVTPAAADPLITPELAEVYETYGADVTTPLGDGEATMDITMSPDTQQPPMPGNKVHQPQVHNAWRFQEP
What is the function of this protein?
Involved in the mineralization and structural organization of enamel.
What are the official names of this protein?
Ameloblastin, Amelin.
What is the protein family that this protein belongs to?
Belongs to the ameloblastin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: ASPG_MYCTU
Sequence: MARLTVITTGGTISTTAGPDGVLRPTHCGATLIAGLDMDSDIEVVDLMALDSSKLTPADWDRIGAAVQEAFRGGADGVVITHGTDTLEETALWLDLTYAGSRPVVLTGAMLSADAPGADGPANLRDALAVAADPAARDLGVLVSFGGRVLQPLGLHKVANPDLCGFAGESLGFTSGGVRLTRTKTRPYLGDLGAAVAPRVDIVAVYPGSDAVAMDACVAAGARAVVLEALGSGNAGAAVIEGVRRHCRDGSDPVVIAVSTRVAGARVGAGYGPGHDLVEAGAVMVPRLPPSQARVLLMAALAANSPVADVIDRWG
What is the function of this protein?
Has a dual function in both nitrogen assimilation and in protection against acid stress during infection through asparagine hydrolysis and NH4(+) release (PubMed:24586151).  Catalyzes asparagine hydrolysis (PubMed:24586151, PubMed:33412160).  Cannot use glutamine (PubMed:24586151, PubMed:33412160).  Required for intracellular survival inside macrophages during host colonization (PubMed:24586151).  Mediates phagosome acidification arrest and resistance to acid stress through the formation of acid-neutralizing NH4(+) ions (PubMed:24586151).  In addition, may induce stress to primary immune cells and compromise the host immune response (PubMed:33412160).
What are the official names of this protein?
L-asparaginase, L-ASNase, L-asparagine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via the ESX-5 / type VII secretion system (T7SS). Secreted in host cells during infection.
Protein: GUAA_COXBN
Sequence: MLKDIHQHRILILDFSSQYAQLIARRVREIGVYCELMPCDIDEETIRDFNPHGIILSGGPETVTLSHTLRAPAFIFEIGCPVLGICYGMQTMAYQLGGKVNRTAKAEFGHAQLRVLNPAFLFDGIEDQVSPQGEPLLDVWMSHGDIVSELPPGFEATACTDNSPLAAMADFKRRFFGLQFHPEVTHTPQGHRILAHFVIHICQCIPNWTTKHIIEDSIRDIQEKVGKEQVIVGLSGGVDSAVTATLVHKAIGDQLVCVLVDTGLLRLNEVDEVLNVFQKHLGAKVICVDAKDRFMKALKGISDPEEKRKIAGEQFIRVFEEQAKKLNVKWLGQGTIYPDVIESAKTKTGKGHIIKTHHNVGGLPLNMELKLIEPLRELFKDEVRKLGLELGLPADLIYRHPFPGPGLAIRILGEVNAEYINILKQADAIFIEELKKSDYYHQVSQAFAVFMPLKSVGVKGDARHYGYIIALRAVKTVDFMTAQWADLPHEFLSKVSHRIVNEIKEVSRVVYDMTNKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: HIS2_BORBR
Sequence: MTPPTAGDDILSRIADTLATRRPEAGGDPQSSYVAKLLSKAPDAFLKKIGEEATELVMAAKDGQPDRIISETADLWFHCLVALTHYNLRPEDVLAELARREGLSGLEEKARRPRD
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCCT_SALPC
Sequence: MKTGALTTFLALCLPVTVFATTLRLSNEVDLLVLDGKKVSSSLLRGAESIELENGPHQLVFRVEKTIRLPGNEERLYISPPLVISFDTQLISQVNFQLPRLENEREASHFNAAPRLALLDGDAMPIPVKLDILAITSTAKVVDYEIETERYNKSAKRASLPQFATMMADDSTLLSDVSELDTVPPQSQTLTEQRLKYWFRLADPQTRHHFLQWAEKQPPS
What are the official names of this protein?
UPF0319 protein YccT.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: Y1619_BARHE
Sequence: MLIDADSCPVKTEIYRVMNRYQLKTFVVANRFFPLPDEALLERVVVSDKFDSADDWIVEHVQEASIVITSDIPLAARVVRAGGVCLSPTGRTFDASSIGHVLALRNLMNDLRGQGKVISSPRPFCCKDRSAFLSALDLAVQRLKRCGY
What are the official names of this protein?
UPF0178 protein BH16190.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: PYGM_RABIT
Sequence: MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKIP
What is the function of this protein?
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
What are the official names of this protein?
Glycogen phosphorylase, muscle form, Myophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the glycogen phosphorylase family.
Protein: RS8_ECOL5
Sequence: MSMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFKVEGDTKPELELTLKYFQGKAVVESIQRVSRPGLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PRTL5_LYSSX
Sequence: ATVQGGIXYRMP
What is the function of this protein?
Peptidase.  Has bacteriolytic activity.
What are the official names of this protein?
Proteinase L5.
What are the subcellular locations of this protein?
Secreted.
Protein: VATE_HALS3
Sequence: MSLETVVEDIRDEARERAKEIRADADERADEIVAEAEADADDIIADAEAEVTAEIDQEREQQLSSAELEAKQMRLEARRDALQSVRSAVEDRIVALDGDEREELTRELLDAASTEFDGADTVRVFGRADDEALISEILDDYDGYEYAGEYDCLGGVVVESDASRIRVNNTFDSILADAWENNLKAISARLFDEEQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type proton ATPase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: PYREL_HALS3
Sequence: MKNVDDLIDDAAALADRGLSRGEIADELNVSRETASWLVERADTNASVAATDTDDSPRDVHVDWSTIGEAGARLSAIGIALADALRDHSHDVDLVVGIEKAGVPLATATANELGTDLATYTPRKHQWDEGDMADLGGSFSRNFASVEDRDCFVVDDTVTSGTTITETIQAVREAGGTPVACGVLADKQGLGDVDGTPIEALLQVIRVGSGDD
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: EFTU_RUEPO
Sequence: MAKEKFERSKPHVNIGTIGHVDHGKTTLTAAITKYFGDFKAYDQIDGAPEEKARGITISTAHVEYETDSRHYAHVDCPGHADYVKNMITGAAQMDGAILVVNAADGPMPQTREHILLGRQVGIPFMVVYMNKVDQVDDEELLELVEMEIRELLSSYDYPGDDIPIIRGSALHAMNGTEPSMGEESIRALMAAVDEYIPTPARAVDQPFLMPIEDVFSISGRGTVVTGRVERGVINVGDSIEIVGIRDTKTTTCTGVEMFRKLLDRGEAGDNIGALLRGIDREGVERGQVLCKPGSVTPHTKFEAEAYILTKEEGGRHTPFFANYRPQFYFRTTDVTGTVTLAEGTEMVMPGDNVGFTVELIAPIAMEDGLRFAIREGGRTVGAGVVSKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.