PharMolix/UniProtQA huggingface dataset:
Protein: MSRQ_SHIB3
Sequence: MRLTAKQVTWLKVSLHLAGLLPFLWLVWAINHGGLGADPVKDIQHFTGRTALKFLLATLLITPLARYAKQPLLIRTRRLLGLWCFAWATLHLTSYALLELGVNNLALLGKELITRPYLTLGIISWVILLALAFTSTQAMQRKLGKHWQQLHNFVYLVAILAPIHYLWSVKIISPQPLIYAGLAVLLLALRYKKLRSLFNRLRKQVHNKLSV
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ, Flavocytochrome MsrQ.
What is the protein family that this protein belongs to?
Belongs to the MsrQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAK_FRATO
Sequence: MGKIIGIDLGTTNSCLAIMDGKTAKVIENAEGHRTTPSVVAYTDSGEILVGQAAKRQAVTNPDNTFFAIKRLIGRKYDDKAVQEDIKKKVPYAVIKADNGDAWVATKEGKKMAPPQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGKIAGLEVKRIINEPTAAALAYGVDSKKGEQTVAVYDLGGGTFDISIIEIADVDGDNQIEVLSTNGDTFLGGEDFDLALMNYLIDEFKKEQGIDLHNDKLALQRVREAAEKAKVELSSAQQTDVNLPYITADATGPKHLNIKVTRAKFESLVSDLVMRSLEPCKKALEDAGLSKSDITEVLLVGGQTRMPLVQEKVKEFFGKEPRKDVNPDEAVAVGAAIQGGVLAGDVKDVLLLDVTPLSLGIETMGGVMTKLIERNTTIPTKKSQVFSTAEDNQPAVTIHVLQGEREMASANKSLGRFDLADIPPAPRGMPQIEVTFDIDANGILNVSAKDKATGKEQNIVIKSSSGLSEEDIEKMVQDAEANAEADKKFHDLVTARNTADNLIHSSRKAIQELGDKVTAAEKEKIEEACKELEAATKGDDKQAIEAKTKALEEAFAPIAQKAYAEQAQAAGAQGGAKAEEPKKEEDVVDADFEDVEDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: END4_YERPN
Sequence: MKFVGAHVSAAGGVDQAVIRAHELEATAFALFTKNQRQWRAAPLAEDVIEKFKLACEKYGYTSAQILPHDSYLINLGHPVTEALEKSREAFIDELVRCQQLGLSLLNFHPGSHLLQIDEDQCLARIAESINIALDATEGVTAVIENTAGQGSNLGFKFEHLAAIIERVEDKSRVGVCIDTCHAFAAGYDLRTEEDCEHTFAALGKIVGFQYLRGMHLNDAKSEFNSRVDRHHSLGEGNIGKTVFSYIMRDSRFDNIPLILETVNMDIWAEEIAWLKSQAEIEPSL
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: CYSA_PECAS
Sequence: MSIEIRNINKQFGQFRALNEINLSIHSGELVALLGPSGCGKTTLLRIIAGLEQPDSGSIIFHGQDVSVHDVRKRNVGFVFQHYALFRHMTVFDNVAFGLRMKPKNIRPSKSDIEKKVHELLNLVQLDWLGDRYPEQLSGGQRQRIALARALIVEPSILLLDEPFGALDAKVRKELRRWLSQLHEDIDLTSVFVTHDQEEAMEVADRIVLMNKGVIEQIGTPAEVYNHPASEFVYHFLGDSNRLKVAQTEETILFRPHEVSLSVQAQDGYQAVTVRDIRPLGALTRLSLKLGEQSELIEAEVAKDDVSLEGLQKGDVIQFKPKRYNHDWEI
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DOK2_BOVIN
Sequence: MEDVVVKQGFLYLQQQQTFGKKWRRFGAALYGGSGCALARLELQEGSEKSRRGEAPRRVIRLNDCLRVSEASGEASSPRDTSTFFLETTERLYLLAAPTAERGDWIQAICLLAFPGRRKELSGLEGKGGRPRMEENELYSSTTAGTPQKEFAVTVRPTEVSERCRLRGSYTLRVGESALELWGGPESGTQLYEWPYRFLRRFGRDKVTFSFEAGRRCVSGEGNFEFETRQGNEIFLALEEAISAQKNAAPPGPQTQPVPVPAVLPRPESPYARPHDSLPPPSPTVPVPTPRQQRGLEGEYAVPFDAVARSLGKSLRGVLAVPPQLPADPLYDSIEDHPPPRPDHIYDEPEGMAALALYDSPQEPRGEAWRRQATADRDSSGLKHGYIVGQDFAASGWPQGTEYDNVVLKKGPK
What is the function of this protein?
DOK proteins are enzymatically inert adaptor or scaffolding proteins.  They provide a docking platform for the assembly of multimolecular signaling complexes.  DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3.  May be involved in modulating Bcr-Abl signaling.  Attenuates EGF-stimulated MAP kinase activation (By similarity).
What are the official names of this protein?
Docking protein 2, Downstream of tyrosine kinase 2.
What is the protein family that this protein belongs to?
Belongs to the DOK family. Type A subfamily.
Protein: DAPB_MASLA
Sequence: MANQTPIPVIVNGAAGKMGRETIKAVVQAADMTLMGAVDTNPEYQGKDAGEVAGLNEPTEVPITDQLEPILAYVAGERHLQPGVMVDFTHPDAVYDNVRSAIAYGIRPVVGTTGLSSKQIEQLADFAEKASTGCLIIPNFSIGMVLLQQAAIAASQYFDHVEIIELHHNQKADAPSGTAIQTAQMLAEMGKTFNQPAVKETEKLPGARGSLAGEGIRIHSVRLPGLIAHQEVIFGAPGQIYTLRHDTSDRTAYMPGVLLAIRKVLQLKSLVYGLEKIL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBX9_XENTR
Sequence: MAEGDEDSYTDSLMSNENGRPGETNLQEELQMFRARWMSELTPGLSSGGLENRPCNAAARGPVGKVSETKAKQELAKEAKARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDTKNFLDDANNDSKMADLLSYFQQQLTFQQSKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLVCKGFYICARDPEIWRLACLKVWGRNCVKIVPYTTWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVMMLTTPEDPQTIVPRLRTKNARTDAMLLGHYRLSQDTDNQTKVFAVITNKKEEKPSDYQKYRYFRRPQVQETERSFHVGLQLCSSGRHKFNKLVWIHHSCHITYKSTGETAVTAFDIDKMYTPMFFVRVKSFTAVSERPL
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.
What are the official names of this protein?
F-box only protein 9.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_FLAJ1
Sequence: MINQDSIVALATPSGAGAIAVIRISGAEAVSIGNSVFKSIKNKDLTKQKTHTLHLGHIVDNGKTLDEVLVSVFKGPNSYTGEDTIEISCHGSTYIQQQIIQLLLRKGCRMADAGEFTLRAFLNGKLDLSQAEAVADLISSDNEASHHIAMQQMRGGFSNEIAKLREELLNFASLIELELDFAEEDVEFADRTQFHELLNRIEFVLKRLIDSFAVGNVIKNGIPVAIVGEPNVGKSTLLNALLNEERAIVSDIAGTTRDTIEDELVIGGIGFRFIDTAGIRETKDVVESIGIKKTFEKIDQAQVVIYLFDGLKFKASSSEFVSEIEQIKNKYPLKPLLIVVNKKDILSEDEVLNITQKLENLNAKLLLISAKQKIGVEELKNELLSFVNTGALRNNETIVTNTRHYDSLLKALDEIQKVKFGLETNLSSDLIALDIKEALYQFGLITGQVSNDELLGNIFANFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPDH_RAT
Sequence: MIWTRLPLYGHSKPSTGGWQPLRFDGGAFHLKRTAELARALLVLRLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRGCVQQLQAIGLQPLLAVPTEEEPDSAAKTSEAWYEGNLSAMLHCVDLSRAVADAHGPARNSLMQLKVTALTSPRLCKELSAWIQRPRGSSELRPERLAEAMESGRNLQLSCLSTEQNQHLQASLSRLHRVAQHARAQDVRLLVDAEYTFINPALSLLVAALAMRLDSSEEEGPWVWNTYQAYLKDTHERLERDAKAAHEAGLAFGVKLVRGAYLDKERSVTQLHGKEDCTQPDYEATSRSYSRCLELMLRRVSNHGPRCHLMVASHNEESIRQATRRMWELGIPLDGPVCFGQLLGMCDHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRRLLGRTA
What is the function of this protein?
Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor.  Can also use proline as a substrate but with a very much lower efficiency.  Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline.  Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.
What are the official names of this protein?
Hydroxyproline dehydrogenase, HYPDH, Probable proline dehydrogenase 2, Probable proline oxidase 2, Proline oxidase-like protein.
What is the protein family that this protein belongs to?
Belongs to the proline oxidase family.
Protein: HEXA_PONAB
Sequence: MASSRLWFSLLLAAALAGRATALWPWPQNIQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPDIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIRPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
What is the function of this protein?
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides.  The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2.  The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide.  Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A.
What are the official names of this protein?
Beta-hexosaminidase subunit alpha, Beta-N-acetylhexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 20 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: MET_RAT
Sequence: MKAPTALAPGILLLLLTLAQRSHGECKEALVKSEMNVNMKYQLPNFTAETPIHNVVLPGHHIYLGATNYIYVLNDKDLQKVSEFKTGPVVEHPDCFPCQDCSSKANVSGGVWKDNVNMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNAADIQSEVHCMFSPLAEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPDYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPYDDILYGVFAQSKPDSAEPMNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTEFTTALQRVDLFMGRLNHVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHFTPHVNFLLDSYPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLNGLGCGHFQSCSQCLSPPYFIQCGWCHNRCVHSNECPSGTWTQEICLPAVYKVFPTSAPLEGGTMLTICGWDFGFKKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIVSNSRETTQYSAFSYVDPVITSISPRYGPHAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPGHTVSAEFPVKLKIDLADRVTSSFSYREDPVVSEIHPTKSFISGGSTITGIGKNLNSVSTPKLVIEVHDVGVNYTVACQHRSSSEIICCTTPSLRQLDLQLPLKTKAFFLLDGILSKHFDLTYVHDPMFKPFEKPVMISMGNENVVEIKGDDIDPEAVKGEVLKVGNKSCENLHWHSEALLCTVPSDLLKLNGGELNIEWKQAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLVSGLFLWLRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYLLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVPHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLVSKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSVSELVSRISSIFSTFIGEHYVHVNATYVNVKCVAPYPSLLPSQDNIDGEANT
What is the function of this protein?
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.  Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.  Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.  Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.  The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.  During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.  In adults, participates in wound healing as well as organ regeneration and tissue remodeling.  Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
What are the official names of this protein?
Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GCSH_PORG3
Sequence: MKTPAELKYSKDHEWARQEGDVVFIGITDYAQGELGEIVYVDVTTEGETLEADEVFGSIEAVKTVSDLMMPIAGEVLEVNPDLEEQPELVNSDPYGAGWIIKVKAANAADFDNLLSAAEYEKLIAQ
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RL3_SALA4
Sequence: MIGLVGKKVGMTRIFTEDGVSIPVTVIEVEANRVTQVKDLANDGYRAVQVTTGAKKANRVTKPEAGHFAKAGVEAGRGLWEFRLAEGEEYTVGQSISVELFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGQMGNERVTVQSLDVVRVDAERNLLLVKGGVPGATGCDLIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PARE1_CAUVC
Sequence: MKPYRLSRRAKADLDDIWTYSEQRWGVEQAADYARELQATIEMIAEHPGMGQPDENLRAGYRRCASGSHVVFYRVGVRVEIIRVLHQSMNARAHLG
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Its toxic effect is neutralized by coexpression with cognate antitoxin ParD1 but no other ParD or RelB antitoxin.  Low levels of wild-type toxin in the absence of antitoxin decreases the rate of cell growth, and results in death or loss of colony formation abilities and greatly elongated cells.  Low levels of a mutant missing the last 4 residues leads to loss of cell division while cell elongation continues.
What are the official names of this protein?
Toxin ParE1.
What is the protein family that this protein belongs to?
Belongs to the RelE toxin family.
Protein: EIF3C_DROGR
Sequence: MSRFFANGSDSESESSEEEVPTQFNNKAQNFQFSDDEEEVKRVVRSTKEKRYENLTSIIKTIRNHKKIKDIPNTLSSFEDLTRAYTKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREGRKNLSKNNSKSLGTLRQKVRKYIKDFEDDLARFREAPDQESDVDEGEGDVHDSDADRAGDDSDTGFGVGAKMAELPKAAKSSVQPTKIIADDDDSEDSIDWDPDTESETESSEDENMYQNMRERFLKRTTEKEDKDDDKRKDKRKEQKHKVRKRADDDEDGEGWETVVKGNVVEKPKMFEKDAEIDVPLVLAKLIEIMSARGKKRTDRRLQIDLLFELRDISEQHSLGTAVAIKIHFSIISAIFDYNLKISEPMKLEHWALLLEVMQSMMKLLLANPDINMNESIAEEHEEYATAPFYVRGCPLAAVERLDDEFTKLLKECDPHSNDYVSRLKDEVNVVKTIELVVQYFELSGSNNERCRIYLRKIEHLYYKFDPEVLKRKRGEQQPATGAAGATPAAPVQSSVEVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHDNWFQARDLVLMSHLQDNIDAADPSTRILYNRMMANLGLCAFRQENIKDAHHCLVDLMVTGKPKELLAQGLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMISKTFYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESERVREMLVKFIKEESLRTYLFTYSNVYTSISIPSLSQMYELPLPKVHSIISKMIINEELMASLDDPSETVVMHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRDRGYNRNQNNQGGNWGGQRRDNRSQRNRNQRGHHKQNQQQNQQQQQQQVHTIDEE
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 subunit 8.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMEB_ARCFU
Sequence: MAVEFKKIEGDSIQYFALVIILAAVTALGFYAYVLDHKMGLNGLSNRVPWGIVNAGIPYFIGLSAGSLIVSALAGVFNIKKYKVFSRIAAYMAAAWIIAAILSIALDIGKLYHFMNAVRYFNPTSIFSWNAFLYSSYFVICSIYLLVQFEEMEKATRFMAGLAVFWAVLVHSGTGAIYSFVYSKELYHSALTPPMFIVCAITSGLGLLLANLYFTFRFTKRELDPKLIRGLALIFAGLMMVLGYFLAVEGLEKGYIPALHEAVQFVFLTPTSGVFWSFWLLVIFGIAIPIIIVLNPKTGYDLRWITFAGILHAALVFAERFYLIIPGQVFPEEYLPGYELESLHTLEGYIVSYTPSVFEWLQVIGLIAMVYLIFVVGVKLFALIPERAVEEVVEE
What is the function of this protein?
Has menaquinol-oxidizing activity.  HmeB subunit may function as a menaquinol-oxidizing site.  HmeA, HmeB and HmeE subunits may together catalyze electron transfer from menaquinol to cytochrome c.
What are the official names of this protein?
Hdr-like menaquinol oxidoreductase integral membrane subunit, Hme subunit B.
What is the protein family that this protein belongs to?
Belongs to the NrfD family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUC2_FUSSX
Sequence: MVAQPSPIVGRLKLPESMPSLVSLEELTATKVLVTFLTIVIIAPRVFTVIKNAFSPISSIPGPLLNKLSPWPLTIATIKGTSHHFARSLHEKYGPIVVLAPGMVAVADTKEIKRIIQTEDWTKSEAIYGNFRQDPQRPTLLAYTDKKAYAKRKRMLSSMFGIKYIRSMEPIMMTCVEAAVRQLNKFCDEGTQGVAVVDMQHLIHSLAIDIIGITTFGGSLNVVDNGSHPLPSRLKAGLRIAGLMQLIPWIRFIPFLPTRDPYVDRFTYDIVDGRRQELESSQHSDLLQKLVEASDDSPGSDFRTSDVQDESVVMLTAGSETTANAELFTLMMLLKNPKVMKKLVDEVDQWYPPSEPDRQTDCGYSQAGMVYLQACIDETMRLVPGQATGSPRETSKDDVVLGYRIPAGTTVFPNTQEGHTQDAHWEEPQKFVPERWLEAQATNVPYWPFSAGSRVCIGKHFAFQEMHLTLVTLLRKFKFEYVDGQDESTVFRVAQQLKAESYRMKVSRR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the mycotoxin lucilactaene and the lucilactaene-related compound NG-391 that act as cell cycle inhibitors with potent growth inhibitory activity against malarial parasites, moderate growth inhibitory activity against cancer cells, and no activity against bacteria and fungi (PubMed:32043422, PubMed:35484225).  Within the pathway, LUC2 performs C-20 methyl group hydroxylation of several intermediates (PubMed:35484225).  LUC2 does not perform the full oxidation of the C-20 methyl group into carboxylic acid, which is a prerequisite for the final methylation step (PubMed:35484225).  The pathway begins with the hybrid PKS-NRPS synthetase LUC5 which is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate prelucilactaene B.  Both the cytochrome P450 monooxygenase LUC2 and the hydrolase LUC6 function in parallel in modification of prelucilactaene B.  LUC6 may catalyze the 2-pyrrolidone ring formation to form prelucilactaene C from prelucilactaene B, followed by C-15 hydroxylation by the same enzyme to give prelucilactaene D, which is then converted to prelucilactaene E by epoxidation, and finally to prelucilactaene F by cyclization.  Prelucilactane D, prelucilactaene E, and prelucilactaene F can be converted to dihydrolucilactaene, NG391, and lucilactaene, respectively, via C-20 methyl group hydroxylation by the cytochrome P450 monooxygenase LUC2.  However, LUC2, unlike FUS8 in fusarin C biosynthesis, is not enough for the full oxidation of the C-20 methyl group into carboxylic acid, which is a prerequisite for the final methylation step.  The aldehyde dehydrogenase LUC3 is involved in the biosynthesis by further oxidation of the C-20 alcoholic analog prelucilactaene G into a carboxylic derivative.  This unidentified carboxylic derivative may be converted to demethyllucilactaene.  As the last step, the methyltransferase LUC1 methylates the hydroxyl group at C-21 of demethyllucilactaene to generate lucilactaene (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase LUC2, Lucilactaene biosynthesis cluster protein 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL20_SHESM
Sequence: MPRVKRGVTARARHKKVLKLAKGYYGARSRTYRVAVQAVTKAGQYAYRDRRQKKRQFRQLWIARINAAARQNGLSYSRFINGLKKASIEIDRKILADIAVFDKVVFATLVEKAKEALN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: THII_STAA2
Sequence: MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTIEAMSAAAIKFAQQFEENSTFKIDVKRADKNFPMDTYELQRELGGTVLKQIENVSVNVKRPDHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKRVNKVVHPRYTMTSTRRMMMRVADKLVHQIGALAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFEKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.