PharMolix/UniProtQA huggingface dataset:
Protein: FIXN_RHIME
Sequence: MKHTVEMVVLSVGAFLALVGAGLAQDRLFGAHMWVLFFALLAGTLVLMRRVDFRPAVAGHPGRRREYFDEVVKYGVVATVFWGVVGFLVGVVVALQLAFPELNVEPWFNFGRVRPLHTSAVIFAFGGNALIATSFYVVQRTSRARLFGGDLGWFVFWGYQLFIVLAASGYLLGITQSREYAEPEWYVDLWLTIVWVAYLVAFLGTIMKRKEPHIYVANWFYLAFIVTIAMLHVVNNLAVPVSFLGSKSYSAFSGVQDALTQWWYGHNAVGFFLTAGFLAMMYYFIPKQVNRPVYSYRLSIIHFWAIIFMYIWAGPHHLHYTALPDWAQTLGMVFSIMLWMPSWGGMINGLMTLSGAWDKIRTDPVVRMMVMAVAFYGMATFEGPMMSIKTVNSLSHYTDWTIGHVHSGALGWNGLITFGAIYYLVPKLWNRERLYSVRMVNWHFWLATLGIVVYAAVMWVAGIQQGLMWREYDDQGFLVYSFAETVAAMFPYYVMRAAGGALFLAGALLMAFNVTMTILGRVRDEEPIFGAAPLPAPAE
What is the function of this protein?
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Subunits 1-3 form the functional core of the enzyme complex.  Co I is the catalytic subunit of the enzyme.  Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.
What are the official names of this protein?
Cytochrome c oxidase subunit 1 homolog, bacteroid, Cytochrome CBB3 subunit 1, Cytochrome c oxidase polypeptide I homolog, Heme B/copper cytochrome c oxidase subunit.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CALY_RAT
Sequence: MVKLGCSFSGKPGKETGDQDGAAMDSVPLISPLDVSQLQPSFPDQVVIKTQTEYQLTSADQPKKFADLEGQRLACSHPEEGRRLPTARMIAFAMALLGCVLIMYKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTEMPAIWGNSYRAGKEEHKGTTPAAMTVSTAAAAAAAEGNEPSGKPLDMREKEDPQKAEDVPSQSPK
What is the function of this protein?
Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.
What are the official names of this protein?
Neuron-specific vesicular protein calcyon.
What is the protein family that this protein belongs to?
Belongs to the NSG family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Protein: ALG3_NEUCR
Sequence: MAAPSSRPESNPPLYKQALDFALDVANGRHALSKLIPPALFLVDALLCGLIIWKVPYTEIDWAAYMEQVSQILSGERDYTKVRGGTGPLVYPAAHVYIYTGLYHLTDEGRNILLAQQLFAGLYMVTLAVVMGCYWQAKAPPYLFPLLTLSKRLHSIFVLRCFNDCFAVLFLWLAIFFFQRRNWQAGALLYTLGLGVKMTLLLSLPAVGIVLFLGSGSFVTTLQLVATMGLVQILIGVPFLAHYPTEYLSRAFELSRQFFFKWTVNWRFVGEEIFLSKGFALTLLALHVLVLGIFITTRWIKPARKSLVQLISPVLLAGKPPLTVPEHRAAARDVTPRYIMTTILSANAVGLLFARSLHYQFYAYVAWSTPFLLWRAGLHPVLVYLLWAVHEWAWNVFPSTPASSAVVVGVLGVTVAGVWFGAREEWEPGMKSSSKKEEAAMR
What is the function of this protein?
Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
What are the official names of this protein?
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase, Asparagine-linked glycosylation protein 6, Dol-P-Man-dependent alpha(1-3)-mannosyltransferase, Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRPB_BRUSI
Sequence: MNKPVAPNSYKTGPDEEGMFGIFGGRFVAETLMPLILELQQAYETAKNDPEFKAELNALSTFYAGRPSKLYYAEGLSKHLGGAKIYFKREDLNHTGSHKINNCLGQILLAKRMGKTRIIAETGAGQHGVASATIAARFGLPCIVYMGATDVERQKPNVFRMKLLGAEVKPVSAGNGTLKDAMNEALRDWVTNVEDTYYLIGTAAGPHPYPELVRDFQSVIGTEARQQILEQEGRLPDVIVAAVGGGSNAIGLFHPFLDDASVKIVGVEAGGRGLEGEEHCASMSAGRPSVLHGNRTYLLQNADGQILEGHSVSAGLDYPGVGPEHSWLKDSGRVDYVPILDNEALDAFQLCTRTEGIIPALESAHAIAQAVKMAPTMGKDKVMIVNLSGRGDKDVHTVGKLLGMDI
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: HBB2_TAPTE
Sequence: VHLHGDEKAAVLALWDKVDEEKVGGEALGRLLVVYPWTQRFFDSFGDLSTAAAVMGNPKVKAHGKKVLHSFGEGVHHLDDLKVTFAQLSELHCDKLHVDPENFRLLGNVLVVVLAQQFGKAFTPELQAAYQKVVAGVASALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-2, Beta-2-globin, Hemoglobin beta-2 chain, Hemoglobin beta-minor chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RPO1C_PYRAB
Sequence: MVSSSTIKSLIEKKGKDLPESVKQELYEKLIKYNEKYKLTKAEVETIIDEVVKEYERALVEPGEAVGTVAAQSIGEPSTQMTLNTFHYAGVAEINVTLGLPRIIEIVDARKNPSTPMMTVYLDEEHRYDREKAEEVARRIEGTTLENLARTTTLDLINMEFIVEIDPERLEKSGLTMEKVLKKLQSSFKSAEFEMEGYTLIVRPKKFEKISDLRRLAEKVKKHRLKGLSGVGKTIVRKEGDEYVIYTEGSNFKQVLKVPGVDPTRTKTNNIHEIAEVLGIEAARNAIIEEIMNTMREQGLEVDIRHIMLVADIMTLDGVVRPIGRHGVVGEKASVLARAAFEITVQHLFEAAERGEVDNLSGVIENVLIGQPVPVGTGMVKLTMKLPLRPQKEKEEV
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_SSRV1
Sequence: MAKGRTPRSFSQRYGKWNAKFTAFSNPTVASTILTNVAPIAQGNFQTNVPKFTSVNEQVSAVLTQYGVTGPSRAIYQGYGLKVARALNRIGAGPALTNMVAGLKAYYVSAYGANPEILDAVTNIILGSPTGYVS
What is the function of this protein?
Self-assembles to form a helical, filamentous nucleocapsid.  The capsid proteins wrap around the DNA and maintain it in an A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues.  This certainly protects the viral DNA under conditions such as the extreme desiccation of its host.
What are the official names of this protein?
Major capsid protein, Gp11.
What are the subcellular locations of this protein?
Virion.
Protein: PYNC_ASPNC
Sequence: MSPSTINPESSPLHTYYFSMVEMSIMKLFLDHKIFTLIPTTPGASIPVTTLTTTLNASPSLLTRLTNFLIASGVLSSPQPGHIAHTPKSLQFTDPTSYQALFFAHIFDFFLVPAVKWPGYMAEHGLNEPTSASRTPFGYAAGYPDKTLYEILETMPKRAAQFNATMAASFQPMPVLGMYDFSWIEKLADEERMAIVDVGGGKGQALKEILGAYPGIRPEQCVLFDVDDVIREAVAEAERDDDETWRTVRKIPGSFFSEQPVKGAAVYHIRRVLNDWPDEDCVTILRRIRDAAAPNSRVLISEQILQEEPSLAVAALDLWMLNFGGKRRSEGMFGELAQRTGWKVNGVFRDKESDTGVVELVVA
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of pyranonigrins, a family of antioxidative compounds (PubMed:24106156, PubMed:26414728).  The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase that condenses 6 malonyl-CoA units to an acetyl starter unit, to form a 1,3,5-trioxotetradecane-6,8-dienyl-ACP (PubMed:24106156).  The enoyl reducrase (ER) domain of pynA is likely to be functional during the first two rounds of polyketide chain extension, to generate the saturated C-C bonds of the alkyl side chain (Probable).  PynA subsequently forms the amide bond between the acyl chain and L-serine (PubMed:24106156, PubMed:26414728).  Although pynA has a terminal reductase domain, it appears to require the thioesterase pynI for the release of the straight-chain intermediate from pynA via the formation of a tetramic acid pyranonigrin J (PubMed:26414728).  The methyltransferase pynC then coverts pyranonigrin J to pyranonigrin I via N-methylation (PubMed:26414728).  The FAD-dependent monooxygenase pynG catalyzes an epoxidation-mediated cyclization to form the dihydro-gamma-pyrone moiety, followed by pynD-catalyzed oxidation of the alcohol to the ketone and enolization to yield the characteristic tetramic acid-fused gamma-pyrone core of pyranonigrin H (PubMed:26414728).  Pyranonigrin H is substrate of pynH for dehydration-mediated exo-methylene formation from the serine side chain to produce pyranonigrin E, before the oxidase pynE reduces the exo-methylene of pyranonigrin E into a pendant methyl to form pyranonigrin G (PubMed:26414728).  The FAD-linked oxidoreductase pynB performs the reverse reaction and converts pyranonigrin G back to pyranonigrin E (PubMed:26414728).
What are the official names of this protein?
Methyltransferase pynC, Pyranonigrin biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: MUTS2_AQUAE
Sequence: MREKDLIKLEFDKVKEVLASYAHSPATKEKIQNLKPYTNKEKVKEEIELSKAFFDIAENVRLFEFEDIRELLKKAKLQGAILGVEDILKILNVINLTKEIRRVLSSHVQRLEPLRKVYKKLYTFSPLENLIIGSIDPRGFVKDEASEELLRVRKSIRAVEEEIKKRLDNLINRPDSAKFLSDRIVTIRNGRYVIPVKTSHVKKIFGIVHGTSSSGYTTYVEPQFVIHLNNKLTELKQKEEEEVRKVLQRITEYIGDYAKELLESFEACVEVDFQQCKYRFSKLVEGSFPDFGEWVELYEARHPVLVLVKEDVVPVGILLKEKKGLILTGPNTGGKTVALKTLGLSVLMFQSAIPVPASPNSKLPLFEKVFTDIGDEQSIEQNLSTFSAHVKNMAEFLPKSDENTLVLIDELGAGTDPIEGSALGIGILEYLKKKKAWVFVTTHHTPIKLYSTNSDYYTPASVLFDRETLKPLYKIAYNTVGESMAFYIAQKYGIPSEVIEIAKRHVGEFGEQYIKAMEKLSDYVKKYEEEFRKLEELRKELQKEKEEVEKLRKEYEEAKRKGWKEAYKEAREYLRKLVQESEEIFKKAKEKKEIKEFVSKKREEIENLAPQKPQKLEVGDLVEFMGKKGKVLEVKGNKALVLVDHLRMWLDTRELQKVGKAEPQKETKVTVQTPVMEKRDTLNLIGKDVETAVRELEKFIEEAYSAGYKVVKVIHGIGSGKLKSAVREALSKNEKVKFFRDAYPKEGGSGVTVVYLEYGEET
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: GATB_LEPBP
Sequence: MEYEVIIGLEVHVQLNTNSKIFSTATNEFGGSPNTHISPLCVALPGTLPVLNEVVLEKAVRAGVALGCEITKFTKFDRKNYFYPDLPKGYQISQFDKPYATKGGIHVLLKGEKEEKFIPLTRIHMEEDAGKLIHSHDPSINRSYVDYNRAGTPLIEIVSEPDLRSSDEAYVYLNELKTILRYIQVSDCNMEEGSLRCDANVSIRPKGEKGFRTRVEIKNLNSFKAVKQAIDYEVEWQKDVYSRGESFKQMTKLWDATLLKTIPMRSKEMSHDYRYFPEPDLPTIQISDSFIEDIRKTLPELPRQKKERYKTELGLPEYDAEVLTSEREIAEYFEEALVIAGDAKKTSNWVKDEILGIVNKENISIQEFAIDPVRIGKLVKLINSGEITGKIAKTIFEDMLTTKDQPETIVEKNGLKVVRDDKALEEIVIRVIESQPESVEGWKNGKDRVLGAIVGGVMKETKGKADPKLVNELILAKLGPLGEKKKV
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RDRP_ROTH6
Sequence: MGKYNLILSEYLSFIYNSQSAVQIPIYYSSNSELESRCIEFHSKCLENSKNGLSLKKLFIEYNDVIENATLLSILSYSYDKYNAVERKLVKYARGKPLEADLTVNELDYENNKITSELFPTAGEYTDSLMDPAILTSLSSNLNAVMFWLERHENDTAEKLKIYKRRLDLFTIVASTVNKYGVPRHNAKYRYEYDVMKDKPYYLVTWANSSIEMLMSVFSHEDYLIARELIVLSYSNRSTLAKLVSSPMSILVALVDINGTFITNEELELEFSNKYVRAIVPDQTFDELKQMLNNMRKAGLVDIPKMIQDWLTDCSIEKFPLMAKIYSWSFHVGFRKQKMLDAALDQLKTEYTEDVDDEMYREYTMLIRDEVIKMLEEPVKHDDHLLQDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDMANGRYTPGIIPPVNVDRPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLIYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNAMVLYTDVSQWDSSQHNTQPFRKGIIMGLDILANMTNDARVIQTLNLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRISNKYSFATKIIRVDGDDNYAVLQFNTEVTKQMVQDVSNDVRETYARMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAVLYSNYIVNRLRGFETDREFIMTKIMQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSGQRSGIADEIAASTTFKNYVSKLSEQLLFSKNNIVSRGIALTEKAKLNSYAPISLEKRRAQISALLTMLQKPVTFKSSKITINDILRDIKPFFTISEAHLPIQYQKFMPTLPENVQYIIQCIGSRTYQIEDDGSKSAISRLISKYSVYKPSIEELYKVISLHENEIQLYLISLGIPKIDADTYVGSKIYSQDKYRILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEVINYAIKNGSWISLFCNYPKSEMIKLWKKMWNITPLRSPYTNANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).
Protein: CHO2_DEBHA
Sequence: MKETKVQNTIAGAKGITFSGDTFVVPETHDMVKTLFDPMVRKSYCEMIILLILAANGLVFWLINNNTLRIETFIGLYIFWRLSYNFGIGYLLNVQSNHHRLVKWARKAQVFKKNGSLVSRLAEKEIKSQMGPEYDVQKYPIEFNTWLLFRKVVDLILMSDFTTFICLVVVCAINKDYQFINSDQQEVWLISTRLILGTVLILFNLWVKVNAHNTIKDYAWYWGDFFFRQINNEDLIFDGVFEMVPHPMYSVGYVGYYGFAIISKSYTILTVAIFGHFLQMIFLHYIENPHIDKIYGPSGNEADIEMLLKLKDLRHFDNIKPLVGLLNFTWLRASDMTNLIMVGTYSFTIPYLASLVDTVRVGETGVNPGTILFILTIVIKVFESLSINILLILQSYYKTFTKWYLSNDISVEKTLNNWSIMYNSLISLTYSSFFGLNFYHVLIGLESDKLFINSWVYLRIFLGILLVFTQVWINSSIIDSIGYFGWFYGDFFIPKTSQQKAHLTKAGVYRYLNNPEQIFGVCGIMGVTLIIPSLENLICCVLWVTNNFIRINFIEKAHMIKIYGEREVMKDSGVTKTFKKHLIPGAIQRRLSKGSEDNSDLLNQHRRKSTIMAGATDSLDNFIKELKNTNTRLTKQNILELSQNLYFENSDYKLVIKNLNTTENNLSTAFIGEPIEVEWKAPENHSPKDWIGLYKTVQTTYSRYKTLISSSDRWTQVTSDSGSYVFEGEKLFWEEGIYEFRYHLDGKHDVAYISEPFELTSANIEVPPSTEGSIVLANELKAKVFDRAIVGFGSIDSPIDSAVQKSGSIIQTYNRLAYVISKSTGIHINAKVFLYADNEDELTVHKLSLKLINIRKVLDDLSHAHYPLSEEKKEE
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SP28D_DROME
Sequence: MWRLLLALLLVSSVCCESELFRDDLRTPETMAYINGLMQRRHQMQQEAQQHIQAIPPAVPLQSPGLVNGLGNQNDPALNRISGTSVKPSNLPAAYSNGYVDLATSDRIANSVLNFANILGQHLANGKTQIYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPDTSRLHEQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILANALYFKAFWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYIIQPFKSSVRELMALQKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASSVTYLKKSGPDVLFRGDTPFMVLVRHDPTKLVLFYGLINEPPAAA
What is the function of this protein?
Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction (PubMed:18801354, PubMed:22227521).  Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults (PubMed:18801354, PubMed:22227521).  Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea (PubMed:18801354, PubMed:22227521).  May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and pigmentation (PubMed:18801354).
What are the official names of this protein?
Serine protease inhibitor 28Dc, Serpin 28Dc, Serpin-28D.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOD_RHOP5
Sequence: MPEGALRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEQKTYLQAIPYFDRLDYVAPMNQEHAFCLAAEKLLGIAVPRRAQLIRVLYCEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGSRMHAAYFRIGGVHQDLPPQLIEDIETWCDAFPQVVDDLDRLLTGNRIFKQRNVDIGVVTLPQAWEWGFSGVMVRGSGAAWDLRKSQPYECYAEMDFDVPIGKNGDCYDRYLLRMEEMRQSVSIMKQCIAKLRAPDGQGPVALEDHKIVPPRRGEMKRSMEALIHHFKLYTEGFRVPAGEVYVAVEAPKGEFGVFLVSDGTNKPYKCKIRAPGFAHLQAMDFVTRGHLLADVSAILGSLDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS10_HELPG
Sequence: MEKIRLKLKAYDHRVLDRSVVAIVEAVKRSGSEIRGPIPLPTKNKRYTVLRSPHVNKDSREQFEIRVYSRLIDIISATPETVDSLMKLDLAPEVDVEVTSMETK
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RPOE_STRP7
Sequence: MELEVFAGQEKSELSMIEVARAILELRGRDHEMHFSDLVNEIQNYLGTSNSDIREALPLFYTELNFDGSFISLGDNKWGLRSWYGVDEIDEEIIALEENDDDEVAPKAKKKRVNAFMDGDSDAIDYNADDPEDEDAYEADPALSYDDENPDDEKNEVEAYDAEINEIAPDDLGEDVDLNEDDDEFSDDDAETSEE
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: VPS51_XENTR
Sequence: MATVSGTEEEENAKKRKAHGMLKLYYGMTEEGKACERHLEPTDVDGVHFNPELYLTKLRKESSLSQLMDVEADMVRQIRSLDSEMQTLVYENYNKFISATDTIRKMKNDFKKMEDEMDGLATNMAVITEFSARISSTLQERHQQITKLSGVHTLLRKLQFLFELPARLKKCIELGAYAQAVSYHSKARSVLHQYQHMPSFHGIQTDCQAIMAGLADTLRQRFRDPASSPQDLSECVEMLLNLEEPAHLLCDEFLAHGRGRLASHLSDLQESGDILEFVDRGCGGFISDACLLAASYQSLFSKEAGSTAQMAEAKLTSFLEELSTGYFELVEKRLRQEKSLGDNSLLVRALDRFHRRLQAPSKLVPGCGFNRRGTEIVVRAAQERLAQYLQALKDFFQGCLTDVRQALAAPRLPGKEMPALGDLLAGLSASVLNQIKTVLAAVHLFTAKDVAFSDKPYFKGEFCSQGVREGLIVAFIKSVCQTARQFCEIPGEKGTSTPPALLLLLSRLCLDYETSTISYILTLTDEQFLGQDHSPVTPVSSLCSLARSTAQTLLNQYVKSQGLVVSQMLRKSVETRDWVTTIEPRNVRAVMKRVVEDITGVDVQVGLLYEEGVRKAHSSDSSKRTFSVYSSSRLQGRYAQSYTPSAPMDTNLLSNIQKLFSERIDIFSTVQFNKVSILTGIIKISLKTFLECVRLRTFGRYGLQQIQVDCHYLQLYLWRFVSDENLVHCLLDEVVGSAAHRCLDPAPMEQSVIEVICERG
What is the function of this protein?
Involved in retrograde transport from early and late endosomes to the late Golgi.  The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy.  Acts as component of the EARP complex that is involved in endocytic recycling.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 51 homolog, Protein fat-free homolog.
What is the protein family that this protein belongs to?
Belongs to the VPS51 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Protein: GVPL_HALMT
Sequence: MTEQSSGSATEQATEQETAKQETGRKNEQPEERTVTDGRYLYCLINTTTAESETGSEQESKAGSEQESKAGSEQESEQATVDWSTTGVDDNTVYVIEGESVGAVVHDCERIYDTESPEQVKQWVLRHQHVVDAASDVFGTPLPMRFNTILEGGDTSVTQWLHENHDTVREELTSFAGTWEYRIHLFWEPSTFEAQIEDEDDQLQELQQRQEEAGSGKSFLLKKQYDKRLRERKQNRRAELTTTLQETVRPVVRELLKQGSGSQLAEDTTPTKKEQVTRLAVLADEENETVLGDRLDEIVEQDGVSIKFTGPWPPYTFAPDLG
What is the function of this protein?
May play a structural or regulatory role in gas vesicle synthesis.
What are the official names of this protein?
Protein GvpL.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: PAX5H_CAEEL
Sequence: MEPIWRNYPYPTYPGHHNFQFDPLLSDGSHTGVNQLGGVFVNGRPLADTVRAQIVEMSQHGTRPCDISRQLKVSHGCVSKILGRYYSTGSVRPGVIGGSKPKVATPRVVECIAGYKRANPTMFAWEIRQKLIEDQICGEENVPSVSSINRIVRNKSFMAQLAAPTSVTSSAARPSSATSHHQRSPPRGVQQHMQQSTSVQQLQQLQLTSAATVNSLMTPPAFAMPGTAYSINGLLGTLPQPSLLDDKFTNLSTQSADMSLVYSTGLVGEHDWTMRTPMVILPQNYCGQL
What is the function of this protein?
Transcription factor (PubMed:17021039).  Binds to specific DNA sequence motifs in regulatory elements, for example in the genes encoding transcription factor lin-48, apoptosis regulator ced-9 and neuropeptide-like protein nlp-2 (PubMed:17021039, PubMed:15923112, PubMed:11532910, PubMed:31398431).  Specifies cell fate, playing an essential role in embryonic and larval development (PubMed:9374390, PubMed:10511553, PubMed:31398431, PubMed:17020758).  Involved in morphogenesis of the vulva and uterus in hermaphrodites and of the rectal epithelium of the tail in males (PubMed:9374390, PubMed:15923112, PubMed:31398431, PubMed:17020758).  Plays multiple roles in the development of the egg-laying system, acting in both lin-3/EGF-pathway-dependent and -independent processes (PubMed:31398431, PubMed:17020758).  Positively regulates expression of neuropeptide-like proteins nlp-2 and nlp-7 in uvl cells in an EGF-pathway-dependent manner (PubMed:31398431).  Involved in negatively modulating apoptosis in germline and somatic cells, acting in partial redundancy with transcription factor pax-2, probably by directly regulating transcription of ced-9 (PubMed:17021039).  Positively regulates transcription of lin-48 in hindgut cells and functions in the development of the hindgut (PubMed:11532910, PubMed:15923112, PubMed:10511553).
What are the official names of this protein?
Paired box protein 5 homolog, Egg laying defective egl-38.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL1_MYCMS
Sequence: MAKISKRFKEALSKVEKNKVYPLTQALDLAKQTSTTKFDSTVEVAFNLNIDPRKADQQIRGAVVLPAGTGKTQRVLVLTNTKTKEAEQAKADIVGGEELINRIKNENWFDFDIIVATPEMMAKLGAIGKILGPKGLMPNPKTGTVTIDVAKAVDDIKKRKVEYRADKEGNIHLIIGKVSFEIEKLEENFKAVIDEIRRVKPQTVKGDYIKNITLSTTMGPGIKVQF
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.