PharMolix/UniProtQA huggingface dataset:
Protein: MOAC_BACVZ
Sequence: MNGFSHFNEEGRARMVDISDKSSTVRTAAAISSVHMKHDVYSRIKNREIGKGDVLAVAQVAGIMAAKQTSAIIPMCHPLSLSSVDISFGWEEKDSEAVLHIQASVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTCLMEKTGGKNGDFKRDASEYKVEDQS
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: CKX1_ORYSJ
Sequence: MAAIYLLIAALIASSHALAAHGAGGGVPLAAAAPLPFPGDLAASGKLRTDPNATVPASMDFGNITAALPAAVLFPGSPGDVAELLRAAYAAPGRPFTVSFRGRGHSTMGQALAAGGVVVHMQSMGGGGAPRINVSADGAYVDAGGEQLWVDVLRAALARGVAPRSWTDYLHLTVGGTLSNAGVSGQTYRHGPQISNVLELDVITGHGETVTCSKAVNSDLFDAVLGGLGQFGVITRARVAVEPAPARARWVRLVYADFAAFSADQERLVAARPDGSHGPWSYVEGAVYLAGRGLAVALKSSGGFFSDADAARVVALAAARNATAVYSIEATLNYAANATPSSVDAAVAAALGDLHFEEGFSFSRDVTYEEFLDRVYGEEEALEKAGLWRVPHPWLNLFVPGSRIADFDRGVFKGILQTATDIAGPLIIYPVNKSKWDAAMSAVTPEGEEEVFYVVSLLFSAVANDVAALEAQNRRILRFCDLAGIGYKAYLAHYDSRGDWVRHFGAKWDRFVQRKDKYDPKKLLSPGQDIFN
What is the function of this protein?
Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group.
What are the official names of this protein?
Cytokinin dehydrogenase 1, Cytokinin oxidase 1, OsCKX1.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: GHRB_SALPB
Sequence: MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVARHAQAFASAQGLLGTSETVNRALLEKMPALRAASTISVGYDNVEVDALTARKIVLMHTPTVLTETVADTVMALMLATARRVVDVAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMALAQRAHFGFTMPVLYHARRRHQEAEDRFNARYCDLDTLLQEADFVCVILPLTTETRHLFGTTQFARMKSSAIFINAGRGPVVDENALIAALQNGEIYAAGLDVFEHEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMACAVDNLIDALQGKIEKNCVNPQAAG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_CLOB8
Sequence: MSFNFIKDKDKKIHFIGIGGISMSGLAAVLLNSGYSVSGSDFKDSAIIDKLRSSGAEIYIGHRRENINNVDLVVYTAAIPSDNPELLEAKEKNIALMDRAEFLGQIMKGHKYSVAISGTHGKTTCTSMLSHITLADNLDPTILVGGELDAIGGNFRIGNSEYFLTEACEYKRSFLKFPPYVGIILNIDSDHLDYYKDIDEIADTFLQFSRLIPEDGYLVGYADDQRVNEILSETNCNTLSYGFSDNANLTAKNIHFNTNGCATFDVYKDGNNLFNITLNVPGKHNILNALASICVSLIFNISNDCIIEGLSNCKGAHKRFEYKGKLNGVTVIDDYAHHPTEIKATLSTAKQMNHNKTYCIFQPHTYTRTKALFDEFTECFNDADELILMDIYAAREKNTGLVSSDELGDALRNKGLKCINVHSHDEALNYVKSKLVSGDLLLTVGAGDVVIVGEKYLKA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMA_ALBFT
Sequence: MYKLVLIRHGESTWNLDNRFTGWTDVDLTPLGIEQAKNAGRLLKAEGYEFDVAYTSVLKRATRTLWHVLDEMDRTWLPVVNSWRLNERHYGALQGLNKAETAKQYGDAQVLAWRRSYDTPPPALEPTDPRSERADRRYARLSQDQVPLTECLKDTVARVMPFWYEALAPAIKAGKRVVVAAHGNSIRALVKYLDNISDDDIVGLNIPNGIPLVYELDENLKPIRHYYLGDAEAAAKAAAAVASQGKA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: GRC3_SCHPO
Sequence: MVKRQRIESSNVPLSAFAVRQLTLSKAARKKDNSSGKKRSVSEEESQDKYEDEMKTEGEFPSYKHTLVQVVVPGVDHRTKLHSESSKNDSEITPDINRSKVNPQEYSEFSVASPQTISPSLPLNLDDETVSENVPHSPQSSNDAIPVIKITEENSFRVKDTLYVGLHKDQKLAMVGTFIFRSVRGKFQLFGATYSSACMSWFPLNAPLAFATPVFSAIDNALPAMQISEYEEDSLNLRSFAVPSYSPKEHEYELEPKDILPNFETVIAFRENENGLSKIARVLPFAKRLFSFKNLLQDASSISNNFEITPESWCSFSNQLLFSTSKSDYVVPRLMVCGPKGSGKSSFSRYITNRLLQQYRHIAYLDLDPGQPEVVPSGHISLYYINSPLQGPVFARMLFPTYMLRLHLGDISPQKDPDHYIACVTRLFAEYKDYIFNQEISQKEIIPLIINCPGWIRGGGAELLSSIVDICQPTEVVYMSREDMKSSHREKKSIYQHKEYMPDFLSSRDEFQLTLLESTWQYLPDPNVNKVTSADNRMLGLLSYLYFNCNLQRWDFTTSLTACQPIATAFKGSSKGIDAVNIIGEPLNVNDVAKTINGTLMALYACDTASLDNSNTQRIVSSPEGIPLIINDGLPLDPNTSHCLGLIVLRTIDLKRNEFHFVGPLNLELIKDAYAKSLKIVLERGRLELPVYAMLDHRLAQYSELPYLDRNHDRVAVGAHRRRVRRNIIRRSTFVG
What is the function of this protein?
Polynucleotide 5'-kinase required for both rRNA processing and heterochromatic gene silencing.
What are the official names of this protein?
Polynucleotide 5'-hydroxyl-kinase grc3.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. NOL9/GRC3 subfamily.
Protein: VM1B1_BOTPA
Sequence: SQIKFKPSYIELAVVADHGMFTKYNSNINTIRIVHEMVNTVDGFFRTITSFGEWRERDIIPRSCIMASTISKHNPQCIINQPI
What is the function of this protein?
This protein is a zinc protease from snake venom that is devoid of significant myotoxic and hemorrhagic activities.  It hydrolyzes the Aalpha-chain and more slowly the Bbeta-chain of fibrin and fibrinogen, without affecting the gamma-chains.  It induces cell detachment and a apoptosis (anoikis) in endothelial cells.
What are the official names of this protein?
Snake venom metalloproteinase BnP1, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LDH_THEP3
Sequence: MNKISIIGSGFVGATTAYTLALSGIAKTIVLIDINKDKAEGDALDISHGVPFISPVELYAGDYSDVSGSDIIIITAGAAQKPGETRLDLVKRNTMIFKDIVAKLIKVNDTAIYLIVTNPVDILTYVTYKISGLPYGRVLGSGTVLDSARFRYLLSKHCNIDPRNIHGYIIGEHGDSELAAWSITNIAGIPIDNYCNLCGKACEKDFREEIFNNVVRAAYTIIEKKGATYYAVALAVRRIVEAIFRDENSILTVSSPLTGQYGVTNVALSLPSVVGRNGIVNILELPLSQEEIAAFRRSAEVIKSVIQELDI
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_BACVZ
Sequence: MTKRLILASQSPRRKELLNLLQIPYSIIASRTEEKLNRNLSPEENVQCLAEQKAGAVLAENPDAVVIGADTMVCIDGECLGKPHDREEAAHMLRRLSGRSHQVITAVSIQTHDRKETFCDTTEVTFWPLSEDDIQLYIETKEPMDKAGAYGIQGKGALLVKKIDGDFYSVVGLPVAKTMRALKEFNIKA
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_HALHL
Sequence: MSAAEMCAVAEQEPTATTHRPVLYGAALAALDVRPDGCYVDATYGRGGHARGILERLGPQGRLWVADRDPEALAHARETLADDPRCTVLGAELAELPRLLAEQGLAAGVDGLLADLGISSPQVDNPDRGFSFQRDGPLDMRMDPTTGESAAALLERLSARDIAGVLRQLGEERHAGRIARAIVAARDAGDPPRTTLALARLVEQAVPRREPGRHPATRTFQALRIAVNDELGQLDRFLEGVIDLLAPGGRLAVIAFHSLEDRRVKRFIRRASSVGDLPPSVPVPPAGCQPRLRPLGRDLRADEGEVAGNPRARSAVLRVAERLS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG1_BURTA
Sequence: MPRKTPIERYRNIGISAHIDAGKTTTTERILFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWKGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYKVPRIAFVNKMDRVGADFFRVQRQIGERLKGVAVPIQIPIGAEEHFQGVVDLVKMKAIVWDDESQGVKFTYEDIPANLVEIAHEWREKMVEAAAEASEELLEKYLTDHHSLTEDEIKAALRRRTIANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPADVPAILGHDLHDNEAERHPSDDEPFSALAFKIMTDPFVGQLIFFRVYSGVVESGDTLLNATKDKKERLGRILQMHANERKEIKEVRAGDIAAAVGLKEATTGDTLCDPGKPIILEKMEFPEPVISQAVEPKTKADQEKMGLALNRLAQEDPSFRVQTDEESGQTIISGMGELHLEIIVDRMRREFGVEATVGKPQVAYRETVRTVAEDVEGKFVKQSGGRGQYGHAVIKLEPNPGKGYEFLDEIKGGVIPREFIPAVNKGIEETLKSGVLAGYPVVDVKVHLTFGSYHDVDSNENAFRMAGSMAFKEAMRRAKPVLLEPMMAVEVETPEEFMGNVMGDLSSRRGIVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSATQGRATYTMEFKHYAETPSNVSEAVINAKQVGRG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 1, EF-G 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTAS_STAAR
Sequence: MSSQKKKISLFAFFLLTVITITLKTYFSYYVDFSLGVKGLVQNLILLMNPYSLVALVLSVFLFFKGKKAFWFMFIGGFLLTFLLYANVVYFRFFSDFLTFSTLNQVGNVESMGGAVSASFKWYDFVYFIDTLVYLFILIFKTKWLDTKAFSKKFVPVVMAASVALFFLNLAFAETDRPELLTRTFDHKYLVKYLGPYNFTVYDGVKTIENNQQKALASEDDLTKVLNYTKQRQTEPNPEYYGVAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSSGKEQFTYFPNFFHQTGQGKTSDSEFTMDNSLYGLPQGSAFSLKGDNTYQSLPAILDQKQGYKSDVMHGDYKTFWNRDQVYKHFGIDKFYDATYYDMSDKNVVNLGLKDKIFFKDSANYQAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLNRTGFWIKIPGKSGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDLFSKGHNQVVPFRNGDFITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFKKVNPSKYKYETGPKANSKK
What is the function of this protein?
Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate.  Is required for staphylococcal growth and cell division process (By similarity).
What are the official names of this protein?
Lipoteichoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the LTA synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Processed glycerol phosphate lipoteichoic acid synthase]: Secreted.
Protein: H2BK1_HUMAN
Sequence: MSAEYGQRQQPGGRGGRSSGNKKSKKRCRRKESYSMYIYKVLKQVHPDIGISAKAMSIMNSFVNDVFEQLACEAARLAQYSGRTTLTSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 2-K1, Histone H2B type 2-E1.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Chromosome. Nucleus.
Protein: SYE2_BEII9
Sequence: MSHPIVRFAPSPTGRIHIGNARPALLNFLFARKYHGEFILRFDDTDLERSKEEYAASIEVDLAWLGITPDRTLRQSQRFALYREAAEVLRSKGRLYPCYETAEELDRKRKRQQARGLPPIYDRAALALSEADRAKLEAEGRRPHWRFKLDPGIARWDDLIRGESHIDAASLSDPILLREDGSYLYTLPSVVDDIDCKITHVIRGEDHVTNTAVQIQLFEALAGHGHVPVFGHHNLLSSASGEGFSKRTGSLSIGSLRDQGFESLAVAAAAVLTGSSVAVHPVKSLDELVAGFDLASLSRTQARFDPAELANLSARTLHQLDFETVRDRLAAHDITGYKAKAFWEAVRGNLTVFLDCIDWWRVVEGEIPPVTEDTAFLDLAKNNLPEEPWDEKAWSSWTGRLKDQTGRKGKALFHPLRLALTGRETGPELAALLPLIGRLKATARLSGHVA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLUQ_YERPE
Sequence: MVQQAVIQRSANQRATNQPTEYIGRFAPSPSGDLHFGSLIAALGSYLQARAQGGKWLVRIEDIDPPREVPGAASRILAALEHYGLHWDGPVIYQSQRHEAYRATLNWLEQQGLSYYCTCTRSRIHQLGGFYDGYCRDRHLPASGAAIRLRQTQPVYAFYDKLLGELHAHPALAQEDFIIRRRDGLFAYNLAVVVDDAFQGVTEIVRGADLIEPTVRQIALYQQLQHPVPGYIHLPLALNNQGNKLSKQNHAPPLPNGDPRPILIDALKFLRQPLPEYWQDLDLYLLLRYAVKHWTLVSIPLQGAITPQKTQRHSQSKYGEL
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: ACDH_ECOHS
Sequence: MSKRKVAIIGSGNIGTDLMIKILRHGQHLEMAVMVGIDPQSDGLARARRMGVATTHEGVIGLMNMPEFADIDIVFDATSAGAHVKNDAALREAKPDIRLIDLTPAAIGPYCVPVVNLEANVDQLNVNMVTCGGQATIPMVAAVSRVARVHYAEIIASIASKSAGPGTRANIDEFTETTSRAIEVVGGAAKGKAIIVLNPAEPPLMMRDTVYVLSDEASQDDIEASINEMAEAVQAYVPGYRLKQRVQFEVIPQDKPVNLPGVGQFSGLKTAVWLEVEGAAHYLPAYAGNLDIMTSSALATAEKMAQSLARKAGEAA
What is the function of this protein?
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A.  Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
What are the official names of this protein?
Acetaldehyde dehydrogenase, Acetaldehyde dehydrogenase [acetylating].
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: FCHO1_HUMAN
Sequence: MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGGTMKRHSSRDAAGKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPSCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMAALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYRPGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEAGGSGRLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC
What is the function of this protein?
Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429).  Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits.  May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.  Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969).  Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969).
What are the official names of this protein?
F-BAR domain only protein 1.
What is the protein family that this protein belongs to?
Belongs to the FCHO family.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
Protein: MURG_LEVBA
Sequence: MRLMVSGGGTGGHIYPALALIKALKKREPNSAVMYVGSERGLESTIVPAKGIPFQATRIQGFKRSLSLENFKTVYLFLKSVHEAKKMIRQFKPDVVVGTGGYVSGAVVYAAARLHVPTLIHEQNSVVGITNRFLSRYVDRIAYVFDAALDQLPVNKMVKTGNPRAQEAAEVVSHFSWTEYGLQDDVPTLLIFGGSQGALKINAATVAAIPEFNHREYQVVFVTGQKRYDGVMAQLKGTTVADNVVIKPYIGNMPEVLPRVAAIVGRAGATSLAEITADGIPSILIPSPYVTADHQTKNANSLATVGAAEIIKEADLTGETLIAKADQLMTNDALRQDMATASKQLGVPDAADRVLDVVEALKRD
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PC05_PENCR
Sequence: MADVNTWWVGGSLLLGIWAIVVFFSPDPLAQYPFINSKRPGELFYTQSKIRFITQARSLLKEGLSKTNNAFRLVTNNRILLVLHSKYRNELRDHKSLNNTKPPEDDFFGWLQGFEPFNHVKTNPKVFAAMVRTKLTPSIGAVGIPLSEETDFVLQQQLTDSSEWHQINVKETSLQLVARLSARIFLGPQVCRNPAWIGIMINYTVEAFMTAERLRMWPRWLLWLVHWFLPSCKKLRSQVQEARGIISQVLQQREQNRKGASLETEASDVDTVQWLEDCAKGGYYDPALLQMGLAVVATHTSADLLSQVIFDLCEHPELLQPLREEIVTVITQHGWSKNAIYNLKLLDSVLKESQRLKPMQINITLSDGTLIPKGTYIAMVDDHSLDPNSSYTNGDQYDGYRFIKMRDVPERAHQTQLVSVTSDHTGFGFGNHACPGRFFAATELKIALCHLLLKYDLKLGDQKPQAMTYGFGLSSDPFTQISVRRRQEEISLADGKS
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:26213965).  The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (Probable).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase penC then forms 3-geranylgeranylindole (3-GGI) (Probable).  Epoxidation by the FAD-dependent monooxygenase penM leads to a epoxidized-GGI that is substrate of the terpene cyclase penB for cyclization to yield paspaline (Probable).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase penP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase penQ (PubMed:26213965).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase PC-15 which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase penD (Probable).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase PC-16 and the P. simplicissimum ptmI-ortholog not yet identified in P. crustosum, leads to the production of the prenylated form of penijanthine (Probable).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase PC-22 (Probable).  A series of oxidation steps involving 4 cytochrome P450 monooxygenases (PC-21, PC-05, PC-23, PC-20) and a FAD-dependent monooxygenase (PC-14) are required for the transformation of PC-M4 to penitrems A and E.  Synthesis of these final products is proposed to proceed via penitrems D and C (PC-21, PC-05, PC-14) and penitrems B and F (PC-21, PC-05, PC-14, PC-23) (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase PC-05, Penitrem biosynthesis cluster protein PC-05.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ZYX_MOUSE
Sequence: MAAPRPPPAISVSVSAPAFYAPQKKFAPVVAPKPKVNPFRPGDSEPPVAAGAQRAQMGRVGEIPPPPPEDFPLPPPPLIGEGDDSEGALGGAFPPPPPPMIEEPFPPAPLEEDIFPSPPPPLEEEGGPEAPTQLPPQPREKVCSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFVPKPSTKPAPGGTAPLPPWKTPSSSQPPPQPQAKPQVQLHVQPQAKPHVQPQPVSSANTQPRGPLSQAPTPAPKFAPVAPKFTPVVSKFSPGAPSGPGPQPNQKMVPPDAPSSVSTGSPQPPSFTYAQQKEKPLVQEKQHPQPPPAQNQNQVRSPGGPGPLTLKEVEELEQLTQQLMQDMEHPQRQSVAVNESCGKCNQPLARAQPAVRALGQLFHITCFTCHQCQQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGQPITDRMLRATGKAYHPQCFTCVVCACPLEGTSFIVDQANQPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHSARAQT
What is the function of this protein?
Adhesion plaque protein.  Binds alpha-actinin and the CRP protein.  Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures.  May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
What are the official names of this protein?
Zyxin.
What is the protein family that this protein belongs to?
Belongs to the zyxin/ajuba family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1 (By similarity).
Protein: RL3_RHOP2
Sequence: MRSGVIAQKVGMTRVFTETGEHIPVTVLKLGNCQVLAHRTTEKNGYVALQLGSGARKTVYMPKAERGQFAVAKVEPKRKVAEFRVSEDALIPVGAEIQADHFVVGQFVDVTGTSVGKGFAGGMKRWNFGGLRATHGVSVSHRSIGSTGGRQDPGKTFKNKKMPGHMGVDRITTLNLRVVQLDVERGLILVEGAVPGSKGGWISVRDAVKKALPADAPKPGKFRLANGGEEAAAPAAEQEGV
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: TRPA_MICAN
Sequence: MTAVTECFRSLRSQGNCALIPFITAGDPDLSTTAQALRILDRAGADLIELGVPYSDPLADGPVIQSAATRALNRGVKLEDVLEIVKNAQGEVKAPIILFTYYNPIYHRGIDVFLDQIKAAGVSGLVVPDLPLEEAESLLQPAAAKGIEVILLVAPTSPPERIQAIALQSQGFIYLVSVTGVTGMRKQVATRVEELLDSIRSVTDKPVGVGFGISEPTQALQVKNWGADAVIVGSAMVKRLADNSPSDGLKSLEEFCRSLKQAIQ
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: IMO32_YEAST
Sequence: MMILGKAGILAQYGTIYVRQNTIRNNLSSCIFKQSLCAFHSLAKVLQQKQVPLDLSYDIIKRDAVKTGDEGKPRPPIIILHGLFGNKLNNRSIGRNLNKKLGRDVYLLDLRNHGSSPHSSVHNYEVMSEDVKHFITKHELNTNGGPIIIGHSMGGKVAMMLVLKNPQLCSMLVCIENAPVSLRPNAEFVEYIKALMEIVNDKGKTIRTLKQADEHLAERIGGNELVRRFLLTALKKVKMDNSSSVSSYTFEERIPLATLKDAIVKGEIAAWPLDPARERWTRPALFIRATQSHYVVDEYLPIIGAFFPRFETRDIDAGHWVNAEKPGECAESIVDFVERHED
What is the function of this protein?
Probable alcohol acetyltransferase that uses acetyl-CoA to synthesize acetate esters from various alcohols (Probable).  Not involved in the synthesis of ethyl acetate (PubMed:28356220).
What are the official names of this protein?
Probable alcohol acetyltransferase, AAT, Intermediate cleaved by mitochondrial octapeptidyl aminopeptidase protein 32.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
What are the subcellular locations of this protein?
Mitochondrion.