PharMolix/UniProtQA huggingface dataset:
Protein: AQPZ_ECOLI
Sequence: MFRKLAAECFGTFWLVFGGCGSAVLAAGFPELGIGFAGVALAFGLTVLTMAFAVGHISGGHFNPAVTIGLWAGGRFPAKEVVGYVIAQVVGGIVAAALLYLIASGKTGFDAAASGFASNGYGEHSPGGYSMLSALVVELVLSAGFLLVIHGATDKFAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTAVAIFQGGWALEQLWFFWVVPIVGGIIGGLIYRTLLEKRD
What is the function of this protein?
Channel that permits osmotically driven movement of water in both directions.  It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells.  It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
What are the official names of this protein?
Aquaporin Z, Bacterial nodulin-like intrinsic protein, Water channel AqpZ.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACDH2_PSEPW
Sequence: MSSTRIPVAIIGSGNIGTDLMIKILRCSDTLEVGAMVGIDPASDGLARAERLGVPTTAGGIDGLLALPNFKEIRIAFDATSAGAHKVHDSKLRAHGVRIIDLTPAAVGPYVVPVVNFAEHAHEPNLNMVTCGGQATIPIVHAVAGVAPVHYAEIVAAISSKSAGPGTRANIDEFTETTSRAIVEVGGAARGKAIIVLNPAEPPLIMRDTVYCFVPLDADTQAIVDAVEQRVAEVNRYVPGYRLKQHVQFEHFTENNRQNIPGLGWSTGIKVAVYLEVEGAGHYLPAYAGNLDIMTSAALTVAERIAQAQFTDQGL
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: LRIQ1_MOUSE
Sequence: MEDSDDSEAKLREEIEAELDKISISSLENDEVENDSVSDTQSDSSDTDLLELPESVLHYINVIKNKSKTAEELILQDVEDTDIFSDYKKGCNHGTVTDSHMHLRTGSLPESKANAEQLMKILSVIEKEEFMRSLAPSARCVSVREIITPDTPMDEYILPDEADLSFGYFEVEERCRKSFEAWQDKQQELEEKDKETLEAQNEREKRTFQEEDEKRQCWMRQFEVEKKHLEDLQKQDQDKMNDELHKEEKIWKEKYRQHEEHIRNLHLKMEEERTRLSELQEKEKARLFKLRYDAAVKIQATYRASVTYRKYSPIIKEQMEKKRRRAQELKEKEAKIRQKEEEKRRRLEEEQRVEEEKKKKMLEERRRREREYEEKKSILRQEREEQRSKEVIRLREHAHSPLIITCALKKGDCHGKQQAIAHVPKGKGTIAKESVDSNSKKQEDACLAQQLNKRENTHVQQLAMKKSTGIKLKPNQAILVELKMNEKNESLPKLKINENLSKNQCSEQPSDQEFNAENVDQKNELENSNLKESVNEQYPWQGLESDTQTEEHVEHVREEKVGQETEKLFGFNQEVSAEDSKQAQGVMEETREGLAEEIEIKEMTQQGGPSDENNSSPISMQKSLPSLTPDNPEPVERSVTLEEDQETDLKSERIEEIPEEGVLSCDAAVINADASVHTEGEADLQDSASGKLAPSEEAGSHSANNLLATEEVEDSPKSEIQEALEKGQQTKAEADGVLTCSVSQLTVLSSVEERRLAWVKTFKPWAEIFEQNQHKKIVKKRRLVKCPPNTMPPLDPSAILQYGPWKSLKQVPVITFQGLPGCSLSTLAECSNLQILSLRRCGLTSLQGLSHCTRLKYIDAQENHIEAISCENLENLSVVLLNNNLLTSIHGFDGCTNLQSLELSHNKITRISGLESLKYLQELTVDHNQLISTKGLCEAPTIVYLDCSHNHLTGIDGIGNCGLLQIIKLQGNYLREPPSLRNHVLLRELHLDDNSISSVEGLSSCWLPLLQYLSISQNSLATIVPLFHLVSLEKLDVSNNCLSDLTNVMCWFNACYSLRELCLTGNPVLQEINWRDSILKTLPALRVLNGDMLNSYANDRIEEHYHQDLRCLLALCQYQLQEFNLLPEKYITQKRDILTLHAVDRLSQYYKDLMKLSHECRRAHEQGDVNTTERSAAETNKNHPDFSNTDSALQNKTLHAQTNSCEADSPATSPNPLDTVFRPSTSHCEELRGRNQEKLMAHKSEQSRISSRSNSRASFIEMKMADSPMSNHHNAERSSPTKAAMVIQAQWRSYIAHRQINCSAEMHPTTTEPLQDPLINNQTTSNEERRKTNMDIQEQREKAALHIQAVWKGFILRKKLATARKAIKDEESGEEYEEIDLEDFEFDEDALEKDWPALDSTGFPSQTLPLSNQLPWPKNSRTLRHDETSPTIPVRPAQAWLCNEKENVMSSEYTQLSSRSESGILSWTPDSKTSRKNLLQSEKEEKISEEWGFKDISTAQQMLKRAKKMKSKKLRKKLEPSVRLALFKKAKNKVSVTKSSKKTQLRRDNYFEAHISSQDEEEEAVSKATAAKEKLERSQEYTYQWLHTQVGFPEATSSRNLKCNHFLPELDPDVLNGGRVQLVARLVSREDTDLDLFSMTSASALSVNKDKKSQTHRYSTGSSSKLWFPSELI
What are the official names of this protein?
Leucine-rich repeat and IQ domain-containing protein 1.
Protein: ERA_LISMC
Sequence: MSEPFKSGFVAIVGRPNVGKSTLLNHIIGQKIAIMSDKAQTTRNKVQGVYTTDESQIIFIDTPGIHKPKHKLGDFMVKIALNTFQEVDLIYFVIDASTGFGRGDEFIIEKLKNVQTPVFLLINKIDLIAPEDLFKLIEQYRDLMDFDEIIPISALQGNNVPNLLEQTNANLEIGPMYYPKDQITDHPERFIISELIREQVLQLTREEVPHSVAVVIEGIEKNPKTEKLTINATIIVERSTQKGIIIGKQGQMLKQIGMRARKEIERLLGSKVFLEIWVKVQKNWRDKEHYLQDYGFDREEY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: CSRA_ERWT9
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKTQQTSY
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE1_STAES
Sequence: MSFKMTQSQYTSLYGPTVGDSVRLGDTNLFAQVEKDYANYGDEATFGGGKSIRDGMAQNPNVTRDDKNVADLVLTNALIIDYDKIVKADIGIKNGYIFKIGKAGNPDIMDNVDIIIGATTDIIAAEGKIVTAGGIDTHVHFINPEQAEVALESGITTHIGGGTGASEGAKATTVTPGPWHIHRMLEAAEEMPINVGFTGKGQAVNHTALIEQIHAGAIGLKVHEDWGATPSALSHALDVADEFDVQVALHADTLNEAGFMEDTMAAVKDRVLHMYHTEGAGGGHAPDLIKSAAYSNILPSSTNPTLPYTHNTVDEHLDMVMITHHLNASIPEDIAFADSRIRKETIAAEDVLQDMGVFSMVSSDSQAMGRVGEVVTRTWQVAHRMKEQRGPLDGDFEYHDNNRIKRYIAKYTINPAITHGISDYVGSVEAGKLADLVMWEPEFFGAKPDLVVKGGMINSAVNGDANGSIPTSEPLKYRKMYGQFGGNITHTAMTFVSNTAYENGIYRQLNLKRMVRPVRNIRNLTKADMKNNNATPKIDVDPQTYEVFVDGNKITSEAATELPLTQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_STRCO
Sequence: MPAIPSHVPEPSRTDPALIRNFCIIAHIDHGKSTLADRMLQLTGVVEQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPSHDKGATHILNMIDTPGHVDFTYEVSRSLAACEGTILLVDAAQGIEAQTLANLYLAMENDLTIIPVLNKIDLPAAQPEKFAEELANLVGCDPDDVLKVSAKTGLGVDVLLDKVVAEVPAPVGVKDAPARAMIFDSVYDSYRGVVTYVRVIDGQLNKRERIRMMSTGATHELLEIGTNSPEMLSADGLGVGEVGYLITGVKDVRQSKVGDTVTSQHKGATEALGGYKDPRPMVFSGLYPLDGSDYPELREALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLDVIRERLEREFGLDLIATAPNVVYRVIMEDGTEHTVTNPSEFPEGKINEVYEPVVRATILAPTEFIGSIMELCQTRRGTLLGMDYLSEDRVEIRYTLPLAEIVFDFFDQLKSKTRGYASLDYEPTGEQTSSLVKVDILLHGDKVDAFSAITHKDAAYAYGVRLVAKLRELIPRQAFEVPIQAAIGSRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGSVEVPQEAFIAVLSSDDSAGSGKGKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y513_STAA2
Sequence: MRGGGNMQQMMKQMQKMQKKMAQEQKKLKEERIVGTAGGGMVAVTVTGHKEVVDVEIKEEAVDPDDIEMLQDLVLAATNEAMNKADELTQERLGKHTQGLNIPGM
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein SaurJH1_0513.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: BRI3_BOVIN
Sequence: MDHKPLLQERPPAYNLEAGQGEFACAPHGYGAIAAAPPPPYPYLVTGIPTHHPRVYNIHSRNVTRYPANSIVVVGGCPVCRVGVLEDSFTFLGIFLAIVLFPFGFICCFALRKRRCPNCGANFT
What is the function of this protein?
Participates in tumor necrosis factor-alpha (TNF)-induced cell death.  May be a target of Wnt/beta-catenin signaling in the liver.
What are the official names of this protein?
Brain protein I3.
What is the protein family that this protein belongs to?
Belongs to the BRI3 family.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Co-localizes with MGAT1 and IFITM3 at the perinuclear region.
Protein: KAD_HELPH
Sequence: MKQLFLIIGAPGSGKTTDAELISKNNSETIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSSKRIILIDGYPRSVEQMQALDKELNAQNEVILKSVIEVEVSENTAKERVLGRSRGADDNEKVFHNRMRVFLDPLAEIQNFYKAKHLHKVINGERSIEEIVHEMQEYILSFGN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_PHOPR
Sequence: MTGFKQHTGLVVPLDTANIDTDAIIPKQFLQKVTRTGFGQHLFNDWRFLDDAGQQENPDFIMNAPRYQGASILLARENFGCGSSREHAPWALADYGIQVMIAPSFADIFYGNSINNQMVPVRLTDQEVDELFQYVETNEGAEITVDLETMQVTANGKTYSFEIDEFRRHCLLNGLDNIGLTLQHADKIAEYEAKIPAFLV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: FOLD_THERP
Sequence: MAAHILSGRPVVESLHARIQQVLARRAPHQGPPTLTVLLPNDPSAQAYARAIRKQFTTLSLNYRTEEIDDTLDESRFAILLKRLAEDESVTGILALQPLPKGVSRRSLARLMPPTKDVDGVSFEQQGRLAIGSPWIAPSTPLGGLILLQHYGIEVAGRHAVVIGRSPVVGRPLALLLLARDATVTICHRRTPDLAKLTRQADLLFVAAGQPHLVKPDMVAPGAVVIDFGVSVRDGRLIGDVDPAVAEVASALTPVPGGTGPVTTAVLALNLLRLAGLLEENDLFPGAP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ZN500_HUMAN
Sequence: MATVPGLQPLPTLEQDLEQEEILIVKVEEDFCLEEEPSVETEDPSPETFRQLFRLFCYQEVAGPREALSRLWELCCRWLRPELRTKEQILELLVLEQFLTVLPGEIQARVREQQPESGEEAVVLVEGLQRKPRKHRQRGSELLSDDEVPLGIGGQFLKHQAEAQPEDLSLEEEARFSSQQPPAQLSHRPQRGPLLWPERGPPAPRHQEMASASPFLSAWSQVPVNLEDVAVYLSGEEPRCMDPAQRDAPLENEGPGIQLEDGGDGREDAPLRMEWYRVLSARCQGPGHPLPGQRPAPVRGLVRPDQPRGGPPPGRRASHGADKPYTCPECGKGFSKTSHLTKHQRTHTGERPYKCLVCGKGFSDRSNFSTHQRVHTGEKPYPCPECGKRFSQSSSLVIHRRTHSGERPYACTQCGKRFNNSSHFSAHRRTHTGEKPYTCPACGRGFRRGTDLHKHQRTHMGAGSLPTLQPVAPGGPGAKA
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 500, Zinc finger protein with KRAB and SCAN domains 18.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BDSD_ANEVI
Sequence: MNKALFLCLVVLCAAVVFAAEDLQKAKHAPFKRATACFCPGKADRGDLWILRGDCPDGYGYTTYCYKGPNICCYPH
What is the function of this protein?
Blocks Kv3 voltage-gated potassium channels.  Reduces blood pressure.
What are the official names of this protein?
Kappa-actitoxin-Avd4m, Kappa-AITX-Avd4m, Antihypertensive protein BDS-13, Blood depressing substance 13, BDS-13.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RBFA_ECOLI
Sequence: MAKEFGRPQRVAQEMQKEIALILQREIKDPRLGMMTTVSGVEMSRDLAYAKVYVTFLNDKDEDAVKAGIKALQEASGFIRSLLGKAMRLRIVPELTFFYDNSLVEGMRMSNLVTSVVKHDEERRVNPDDSKED
What is the function of this protein?
One of at least 4 proteins (Era, RbfA, RimM and RsgA/YjeQ) that assist in the late maturation steps of the functional core of the 30S subunit.  Essential for efficient processing of pre-16S rRNA (PubMed:9422595, PubMed:12963368, PubMed:12628255).  Probably part of the 30S subunit prior to or during the final step in the processing of 16S free 30S ribosomal subunits.  Probably interacts with the 5'-terminal helix region of 16S rRNA (PubMed:7535280).  Has affinity for free ribosomal 30S subunits but not for 70S ribosomes (PubMed:7535280, PubMed:12963368).  Overexpression suppresses a cold-sensitive C23U 16S rRNA mutation (PubMed:7535280).  Overexpression decreases the lag time following cold-shock by about half, leading to faster adaptation and increased protein synthesis (PubMed:8898389).  Overexpression also partially suppresses a rimM deletion mutant and partially rescues its 16S rRNA processing deficiency (PubMed:9422595).  Its function overlaps that of Era in ribosome biogenesis (PubMed:16825789).  A number of RbfA mutants suppress RsgA/YjeQ deletions, in all cases less RbfA is bound to the 30S ribosome (PubMed:21102555).  Released from 30S ribosomes by RsgA; stimulates the ribosome-associated GTPase activity of RsgA (PubMed:21102555).
What are the official names of this protein?
30S ribosome-binding factor, Protein P15B, Ribosome-binding factor A, RbfA.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=About 1/3 associates with free 30S ribosomal subunits at 37 degrees Celsius, 6 hours after a 15 degrees Celsius cold-shock about 4-fold more protein is associated with 30S ribosomes (PubMed:7535280, PubMed:12963368).
Protein: RL7_NEISI
Sequence: MAITKEDILEAVGSLTVMELNDLVKAFEEKFGVSAAAVAVASSAGPAAAAEEKTEFDVVLASAGDQKVGVIKVVRAITGLGLKEAKDIVDGAPKTIKEGVSKAEAEDIQKQLEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: GB_EBVB9
Sequence: MTRRRVLSVVVLLAALACRLGAQTPEQPAPPATTVQPTATRQQTSFPFRVCELSSHGDLFRFSSDIQCPSFGTRENHTEGLLMVFKDNIIPYSFKVRSYTKIVTNILIYNGWYADSVTNRHEEKFSVDSYETDQMDTIYQCYNAVKMTKDGLTRVYVDRDGVNITVNLKPTGGLANGVRRYASQTELYDAPGWLIWTYRTRTTVNCLITDMMAKSNSPFDFFVTTTGQTVEMSPFYDGKNKETFHERADSFHVRTNYKIVDYDNRGTNPQGERRAFLDKGTYTLSWKLENRTAYCPLQHWQTFDSTIATETGKSIHFVTDEGTSSFVTNTTVGIELPDAFKCIEEQVNKTMHEKYEAVQDRYTKGQEAITYFITSGGLLLAWLPLTPRSLATVKNLTELTTPTSSPPSSPSPPAPSAARGSTPAAVLRRRRRDAGNATTPVPPTAPGKSLGTLNNPATVQIQFAYDSLRRQINRMLGDLARAWCLEQKRQNMVLRELTKINPTTVMSSIYGKAVAAKRLGDVISVSQCVPVNQATVTLRKSMRVPGSETMCYSRPLVSFSFINDTKTYEGQLGTDNEIFLTKKMTEVCQATSQYYFQSGNEIHVYNDYHHFKTIELDGIATLQTFISLNTSLIENIDFASLELYSRDEQRASNVFDLEGIFREYNFQAQNIAGLRKDLDNAVSNGRNQFVDGLGELMDSLGSVGQSITNLVSTVGGLFSSLVSGFISFFKNPFGGMLILVLVAGVVILVISLTRRTRQMSQQPVQMLYPGIDELAQQHASGEGPGINPISKTELQAIMLALHEQNQEQKRAAQRAAGPSVASRALQAARDRFPGLRRRRYHDPETAAALLGEAETEF
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: FMT_SHIBS
Sequence: MSESLRIIFAGTPDFAARHLDALLSSGHNVVGVFTQPDRPAGRGKKLMPSPVKVLAEEKGLPVFQPVSLRPQENQQLVADLQADVMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDAETGVTIMQMDVGLDTGDMLYKLSCPITAEDTSGTLYDKLAELGPQGLITTLKQLADGTAKPEVQDETLVTYAEKLSKEEARIDWSLSAAQLERYIRAFNPWPMSWLEIERQPVKVWKASVIDTATNAAPGTILEANKQGIQVATGDGILNLLSLQPAGKKAMSAQDLLNSRREWFVPGNRLA
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: ILVC_DEIRA
Sequence: MSAKMYYDRDVDTQVLENKLIAIIGYGSQAHAHAQNLRDSGFNVVVGLREGSSSKAKAEQAGLRVASIEDATKEADVVMLLIPDEQQPAVYEKSIAPHLTAGKALAFGHGFNVHFGRIKPPADVDVFLVAPKGPGHMLRRVYTDGAGMPGIFAVQQDASGKARDIALAYARGIGCTKAGVLETTFKEETETDLFGEQSVLCGGVTHLIQAGFETLVEAGYQPEIAYFETLHEVKLIVDLIYEKGFEGMRHSISNTAEFGDYVTGPRIITDQTKAEMKNVLGDIQSGKFAESFIKDAESGFPYMNEQRSKMRDHTVEKVGKELRDQMPFINKKELEV
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RL32_DESAH
Sequence: MAVPKQKSSKSRGRKRRTHQKVAAPTLTVCPECQEAKLPHAACPACGAYRNRNVRPDAVEA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: STHA_PSEP1
Sequence: MAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDDRRQVGGNCTHLGTIPSKALRHSVRQIMQFNTNPMFRAIGEPRWFSFPDVLKSAEKVIAKQVASRTGYYARNRVDVFVGTGSFADEQTVEVVCPNGVVEKLNAKHIIIATGSRPYRPADIDFHHPRVYDSDTILSLSHTPRKLIVYGAGVIGCEYASIFSGLGVLVELVDNRGQLLSFLDSEISQALSYHFSNNNITVRHNEEYERVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGLENIGIKVNSRGQIEVDEAYRTTVPNIYGAGDVIGWPSLASAAHDQGRSAAGSIVDNGSWRFVNDVPTGIYTIPEISSIGKNEQELTQAKVPYEVGKAFFKSMARAQIAGEPQGMLKILFHRETLEILGVHCFGYQASEIVHIGQAIMNQPGEQNNLKYFVNTTFNYPTMAEAYRVAAYDGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFDA_METAC
Sequence: MAEVSEEIRNLAARHQELQRQAEALRQEMGMIQTSISSCDQTIVTINELKAASEAGKPAETMVPVGFGSYVYAEVKNPDRIIVNLGAEFSAEETAEEAIETLNRRKEQLTKILEQMNASLTRLTQGMQTLEAEAAKLQPGQA
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit alpha, GimC subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCSAP_HUMAN
Sequence: MSPGSGVKSEYMKRYQEPRWEEYGPCYRELLHYRLGRRLLEQAHAPWLWDDWGPAGSSEDSASSESSGAGGPAPRCAPPSPPPPVEPATQEEAERRARGAPEEQDAEAGDAEAEDAEDAALPALPVKDVEDKPEQQTRTRETDKSPTSTEPRQQPSALFARGNRKAVKSPQRSSSKIKENKHPFALYGWGEKQTDTGSQKTHNVCASAPVHEIHESALRAKNRRQVEKRKLVAQRQRAHSVDVEKNRKMKASSSENPWMTEYMRCYSARA
What is the function of this protein?
Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles.  Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis.  Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023).  May play a role in embryonic development.  May be required for proper cilia beating (By similarity).
What are the official names of this protein?
Centriole, cilia and spindle-associated protein.
What is the protein family that this protein belongs to?
Belongs to the CCSAP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, axon. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin.
Protein: NUBP2_ANOGA
Sequence: MLDKVKHIILVLSGKGGVGKSTVSTQLALTLAEADHKVGLLDIDLCGPSVPYLLGLEDRDVHQCDEGWVPVYTSAEKRLAVMSIGFLLKNRSDAVIWRGPKKTAMIKQFLEDVNWDELDYLIIDTPPGTSDEHITVMECLKTVRTEGAIIVTTPQEMALEDVRKEVTFCKKTGIPILGIVENMSGFVCPNCSECTNIFSSGGGHSLAELAKVPHLGTLPIDPRVGELAGTGKACVKELPDCTTSEVLRELVRTLTTVGQ
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NUBP2 homolog.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.