PharMolix/UniProtQA huggingface dataset:
Protein: RS17_ERWT9
Sequence: MTDKIRTLQGRVTSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVIIRECRPLSKTKSWTLVRVVEKAIL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RL10_COXB2
Sequence: MALNLEQKKAMVAEITDIANQAVSAVAADYRGLTVSEMSDLRKSAREARVHMRVYRNTLARRAFKETTYACLEEVLTGPIVLFFSQEEPGAAARLIEKFIKEHERLEVKGLALGGELLPAEKLKAVARLPSREEALSQLAAVLLAPVTKLVRTLNEPIAQVARVMAAVRDQKAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y2477_STAAN
Sequence: MKKQDISVKTVVAIGIGAAVFVILGRFVVIPTGFPNTNIETSYAFLALISAIFGPFAGLMTGLVGHAIKDFTTYGSAWWSWVICSGIIGCLYGWIGLKLNLSSGLFSRKSMIYFNIGQIIANIICWALIAPTLDILIYNEPANKVYTQGVISAVLNIISVGIIGTILLKAYASSQIKKGSLRKE
What are the official names of this protein?
UPF0397 protein SA2477.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RHO3_SCHPO
Sequence: MSSCFGSKKKPIYRKIVILGDGAAGKTSLLNVFTKGYFPQVYEPTIFENYIHDIFVDGNSIELSLWDTAGQEEYDQLRSLSYSDTHVIMICFAVDSRDSLENVITKWLPEVSSNCPGVKLVLVALKCDLRGADEEQVDHSKIIDYEEGLAAAKKINAVRYLECSAKLNRGVNEAFTEAARVALAAQPRGTKDGADESHGTGCIIA
What is the function of this protein?
Involved in controlling cell shape and septation (PubMed:12415007).  Regulates cell separation by modulating the function of the exocyst complex (PubMed:12930742).  Involved in post-Golgi vesicle transport (PubMed:12930742).  Involved in driving sexual development in a palmitoylation-dependent manner (PubMed:23843742).
What are the official names of this protein?
GTP-binding protein rho3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Found at the cell periphery and the growing tips of interphase cells. Localized to the division site during cell division.
Protein: MENC_ECO45
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQETWEDAQSVLLAWVNNWLAGDCEIPQMPSVAFGVSCALAELAETLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRHRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLDKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSPLPLVDVDALERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: TRI41_MOUSE
Sequence: MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELDREEEEEEVGEEEEVEAVGAGGGWDTPMREEDYEGDMEEEAEEEEEVFWSSGIGGSNWDNMDYVWEEEEEEEEEELDYYLGDVADLRGEDEDEEEEVLEEDEEEELDPITQLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVNEQGICPRHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAANRLEEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEIQLQPPEIWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALLLSPDRRGVRLAERRQEVPEHSKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGSGGSSVSSGDASSSRHHHRRRRLHLPQQLLLQREVWCVGTHGKRYQAQSSTEQTLLSPCEKPRRFGVYLDYEAGRLGFYNADTLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
What is the function of this protein?
E3 ligase that plays essential roles in innate antiviral response (PubMed:33640899).  Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (By similarity).  Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (By similarity).  Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (PubMed:33640899).  Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:30485814).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM41, Tripartite motif-containing protein 41.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL16_SALAI
Sequence: MLMPRKPPKGFRKPHHPDRSGASKGGNRVVFGEFGIQALEPAYVTNRQIESARIAMTRHIKRGGKVWITIFPDQALTKKPAETRMGSGKGSPEWWVANVKPGRVLFEMSFPNEQIAREAMRRAIHKLPMKCRIVTREVGES
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RHLB_ECOBW
Sequence: MSKTHLTEQKFSDFALHPKVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTSTFHYLLSHPAIADRKVNQPRALIMAPTRELAVQIHADAEPLAEATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRMYDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEQMNNAEYIEVEPEQKTGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILDEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIGHSIPVSKYNPDALMTDLPKPLRLTRPRTGNGPRRTGAPRNRRRSG
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOG2_HUMAN
Sequence: MSRRKQSKPRQIKRPLEDAIEDEEEECPSEETDIISKGDFPLEESFSTEFGPENLSCEEVEYFCNKGDDEGIQETAESDGDTQSEKPGQPGVETDDWDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDSRLQAASQMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGRQREAAPVSEENEDSAHQISSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLPPGASLKCTVCSYTADSVINFHQHLFSHLTQAAFRCNHCHFGFQTQRELLQHQELHVPSGKLPRESDMEHSPSATEDSLQPATDLLTRSELPQSQKAMQTKDASSDTELDKCEKKTQLFLTNQRPEIQPTTNKQSFSYTKIKSEPSSPRLASSPVQPNIGPSFPVGPFLSQFSFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPLMPKGATCFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMPEALSPNTGQTSINLLNPAAHSADPENPLLQTSCINSSTVLDLIGPNGKGHDKDFSTQTKKLSTSSNNDDKINGKPVDVKNPSVPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLNNPCTSTQEPTEGLGECYHPRCDIFPGIVSKHLETSLTINKCVPVSKCDTTHSSVSCLEMDVPIDLSKKCLSQSERTTTSPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERNSPDVSYERSIIKCEKNGNLKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENRHLFLPQCLYPGAIKKAKGADQLSPYYGIKPSDYISGSLVIHNTDIEQSRNAENESPKGQASSNGCAALKKDSLPLLPKNRGMVIVNGGLKQDERPAANPQQENISQNPQHEDDHKSPSWISENPLAANENVSPGIPSAEEQLSSIAKGVNGSSQAPTSGKYCRLCDIQFNNLSNFITHKKFYCSSHAAEHVK
What is the function of this protein?
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.  Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6.  Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context.  Also required in gonadal differentiation, possibly be regulating expression of SRY.  Probably acts a corepressor of NR2F2 (By similarity).
What are the official names of this protein?
Zinc finger protein ZFPM2, Friend of GATA protein 2, FOG-2, Friend of GATA 2, hFOG-2, Zinc finger protein 89B, Zinc finger protein multitype 2.
What is the protein family that this protein belongs to?
Belongs to the FOG (Friend of GATA) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS2_CROS8
Sequence: MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELSKISSRKGKILFVGTKRAASEAVKEAANSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVSLYLNAVAATVREGRSQDLAAQAEESFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: ATPB1_BURP6
Sequence: MSTAALVEGKIVQCIGAVIDVEFPRESMPKIYDALILEGSELTLEVQQQLGDGVVRTICLGASDGLRRGVVVKNTGNPISVPVGKPTLGRIMDVLGRPIDEAGPIESENKRSIHQKAPAFDELSPSTELLETGIKVIDLICPFAKGGKVGLFGGAGVGKTVNMMELINNIAKEHGGYSVFAGVGERTREGNDFYHEMKDSNVLDKVALVYGQMNEPPGNRLRVALTGLTMAEHFRDEGLDVLFFVDNIYRFTLAGTEVSALLGRMPSAVGYQPTLAEEMGKLQERITSTKKGSITSVQAVYVPADDLTDPSPATTFGHLDATVVLSRDIASLGIYPAVDPLDSTSRQIDPNVIGEEHYSITRRVQQTLQRYKELRDIIAILGMDELSPEDKLSVARARKIQRFLSQPFHVAEVFTGSPGKYVPLKETIRGFKMIVDGECDHLPEQAFYMVGTIDEAFEKAKKIQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta 1, ATP synthase F1 sector subunit beta 1, F-ATPase subunit beta 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RK2_CALFG
Sequence: MAIHLYKTSTPSTRNGAVDGQVKSNPRNNLIYGQHHCSKGRNARGIITARHRGGGHKRLYRKIDFRRNEKDISGRIVTIEYDPNRNAYICLIHYGDGEKRYILHPRGAIIGDTIVSGTEVPISMGNALPLTDMPLGTAIHNIEITLGKGGQLARAAGAVAKLIAKEGKSATLRLPSGEVRLISKNCSATVGQVGNVGVNQKSLGRAGSKRWLGKRPVVRGVVMNPVDHPHGGGEGRAPIGRKKPTTPWGYPALGRRSRKRNKYSDSFILRRRK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYS_LEVBA
Sequence: MLDLKLIRQEPDFIKEKLATRGVDPADIDALLELDAKRRELIVKSETMKAQRNTVSDEISQLKRNKEDADDKIKEMRQVSADIKDIDAQLDTLKDQVQDAAAHLPNIPNDNVPVGLTEDGSVELRQWGEKPNMDFTPKAHYEIGEDLGILDFEAGAKVSGSRYLYYLGAGARLERAVYNFFLDENTKAGFKEVLPPYIVNDDSMYGTGQFPKFKEDVYQLKDEAMTLIPTAEVPLVNYYRDEVIPEEELPVWFTALTPAFRSEAGSAGRDTRGLIRLHQFNKVEMVKFCKPENSWAELEALTKHAESLLQKLGLAYHVITLTTSDMSFTAAMTHDLEVWFPEQQTYREISSCSNTTDFQARRAHIQYRDENGKLQYVHALNGSGLAVGRAVAAILENYQNADGSVTIPDVLVPYMGGLTKITK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHAA_SALHS
Sequence: MTTQLEQAWELAKQRFAAVGIDVEEALRQLDRLPVSMHCWQGDDVAGFENPEGSLTGGIQSTGNYPGKARNATELRADLEQALRLIPGPKRLNLHAIYLESDTPVARDQIKPEHFKNWVEWAKANRLGLDFNPTCFSHPLSADGFTLSHPDAKIRQFWIDHCKASRRVSAYFGEQLGTPSVMNIWIPDGMKDITVDRLAPRQRLLEALDEVISEKFDPAHHIDAVESKLFGIGAESYTVGSNEFYMGYATSRQTALCLDAGHFHPTEVISDKISAAMLYVPRLLLHVSRPVRWDSDHVVLLDDETQAIASEIVRHNLFDRVHIGLDFFDASINRVAAWVIGTRNMKKALLRALLEPTDQLRQLEASGDYTARLALLEEQKSLPWQAVWEMYCQRHDTPTGSQWLDSVRTYEKEILSKRS
What is the function of this protein?
Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
What are the official names of this protein?
L-rhamnose isomerase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_BORAP
Sequence: MKAYDIIVSPMLTEKTNTQRESINVYVFKVNKRANKKEVGAAIKELFNVTPVSCNLLNIKSKAKVVVSRKGYPIGKGKTSSWKKAYVYLKKEDKIDIF
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: GP8_BPMU
Sequence: MNVKIRNEIQALIRIQERNNNGGELREFICAREVDGYGEKTYLITFDHYSICARYCGESISRAIASGDAFNVDLWEYVMDREYICASDPEAREMWQRIWRDYRLMAKGWARCCYSSLALKAVQLSLRHIPASLREPLLY
What are the official names of this protein?
Uncharacterized protein gp8, E7, Gene product 8, gp8.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: PCP_BACMK
Sequence: MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIGEYKIISKQVPTVFHKSIRVLKEYIEELSPEMIICIGQAGGRPDITIERVAINIDDARIADNEGNKPVDMPVVEEGPIAYWSTLPMKAIVKKLREEGIPSSVSQTAGTFVCNHLFYGLMHELEKHDKKIKGGFVHIPFLPEQASNYPGQPSMSLSTIRKGIELAIEVATEVEVDIVACGGATH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_RHOP5
Sequence: MAAENPSVSGVAGRYATALFELARDQKSVDAVKADLDRFKAMLAESPDLTRLVRSPVFSADAQGKALVAVLAKAGIGGIAANFLQLLNANRRLFAVHDVIRAFGALVAKFKGEATADVTVAEPLNDQNLDALKSALKSVTGKDVTLNVNVDPAIIGGLVVKLGSRMVDSSLRTKLNSIKHAMKEAG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FGF1_BOVIN
Sequence: MAEGETTTFTALTEKFNLPLGNYKKPKLLYCSNGGYFLRILPDGTVDGTKDRSDQHIQLQLCAESIGEVYIKSTETGQFLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKHWFVGLKKNGRSKLGPRTHFGQKAILFLPLPVSSD
What is the function of this protein?
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration.  Functions as potent mitogen in vitro.  Acts as a ligand for FGFR1 and integrins.  Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades.  Binds to integrin ITGAV:ITGB3.  Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling.  Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1.  Can induce angiogenesis (By similarity).
What are the official names of this protein?
Fibroblast growth factor 1, FGF-1, Acidic eye-derived growth factor II, EDGF II, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1, Prostatropin.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 (By similarity).
Protein: COAX_LEGPA
Sequence: MILCIDVGNSHIYGGVFDGDEIKLRFRHTSKVSTSDELGIFLKSVLRENNCSPETIRKIAICSVVPQVDYSLRSACVKYFSIDPFLLQAGVKTGLNIKYRNPVEVGADRIANAIAATHSFPNQNIIVIDFGTATTFCAISHKKAYLGGAILPGLRLSADALSKNTAKLPSVEIIKTESVVGRSTIESIQSGVYYGVLGACKELIQRIHHEAFNGDQILILATGGFASLFDKQGLYDHLVPDLVLQGIRLAAMMNTA
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H3_KLULA
Sequence: MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRFQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQESVEAYLVSLFEDTNLAAIHAKRVTIQKKDIKLARRLRGERS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DNAA_BUCAP
Sequence: MSLCLWKQCLDRLQSELPSTEFSMWIRSLKAKLNNNILEIYAPNQFILDWVKDKYLIHFKKILQDFCGSNSPFIKFKVYQTSKEKKFKKNILQKIQNLNAKPIWDKIPIFKKSSHRSNINKKHSFENFIEGKSNQLARAAASQVAKNPGNSYNPLFLYGGTGLGKTHLLHAIGNGILAYKYNVKIIYMHSERFVQDMVKALQNNAIEKFKLYYRSVDALLIDDIQFFAHKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIDPPELETRVAILIKKADENNIVLSDEVAFFIAKHLRSNVRELEGALNRVIVNANFTHRSITVEFVREALRDILALQEKLVTIANIQKTVAEYYKIKVADLLSRRRSRSVARPRQMAMAMAKELTNHSLPEIGDAFSGRDHTTVLHACRKIEQLRKENHDIKEDFSNLIRTLSV
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_XANOR
Sequence: MTPILFVDRDGTLITEPADYQIDAYEKLRFVDHVIPAMLKLRDAGYQFVIVSNQDGLGSESFPRASFDGPNNLMLQIFASQGIEFREVLIDCSWPSDNAPTRKPGVGLMVPYLQDRTIDWARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWPGIAHELADAPRRAVVQRNTKETRIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALDIRAEGDLHIDEHHTIEDTGLALGQALREALGDKRGIGRYGFDPESSPWQVAGDTAQHGFTLPMDETIASAALDFSGRPYFVFDGQFKRDRLGDMPTELVPHFFRSICDASGVNLHLTVRGENDHHKVEACFKALARALRQAIRREGSALPTTKGAL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRC46_RAT
Sequence: MPGDKQEAKNATQKTEEGVHITEALITKRNLTFPEDEDLSEKMFHTLDDLETVRLDGEGITCIGNLERLRNIHSLYLQSNKIQRIENLACITSLRFLSLAGNQIRHVENLLDLQYLQFLDLSENLIETLKLDELPQSLLILNLCGNPCTNQDGYRKMVIGALPLLLDLDKQPILERWTSDEEDKSSDEEEEFPELNGPFCAERGFFKDLEQELHQHQERRQQAALTEHLSRMETQPVLTDLPLLPAVPMAGDCSPAVTEEPGKEAAPKATSSTQMASSSKKQVPRNQKGSVQARKGALAATASKTSLAAAPSMTKSTNKRGTK
What are the official names of this protein?
Leucine-rich repeat-containing protein 46.
Protein: PSBH_PHYPA
Sequence: MATQIIDDTPKTKGKRSGLGDILKPLNSEYGKVAPGWGTTPLMGVAMGLFAVFLVIILELYNSSVLLDGVPVSW
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H, Photosystem II 10 kDa phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NAPG_ECOL6
Sequence: MSRSAKPQNGRRRFLRDVVRTAGGLAAVGVALGLQQQTARASGVRLRPPGAINENAFASACVRCGQCVQACPYDTLKLATLASGLSAGTPYFVARDIPCEMCEDIPCAKVCPSGALDREIESIDDARMGLAVLVDQENCLNFQGLRCDVCYRECPKIDEAITLELERNTRTGKHARFLPTVHSDACTGCGKCEKVCVLEQPAIKVLPLSLAKGELGHHYRFGWLEGNNGKS
What is the function of this protein?
Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.
What are the official names of this protein?
Ferredoxin-type protein NapG.
What are the subcellular locations of this protein?
Periplasm.
Protein: RSLA_MYCTO
Sequence: MTMPLRGLGPPDDTGVREVSTGDDHHYAMWDAAYVLGALSAADRREFEAHLAGCPECRGAVTELCGVPALLSQLDRDEVAAISESAPTVVASGLSPELLPSLLAAVHRRRRRTRLITWVASSAAAAVLAIGVLVGVQGHSAAPQRAAVSALPMAQVGTQLLASTVSISGEPWGTFINLRCVCLAPPYASHDTLAMVVVGRDGSQTRLATWLAEPGHTATPAGSISTPVDQIAAVQVVAADTGQVLLQRSL
What is the function of this protein?
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigL.  ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP).  RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor (By similarity).
What are the official names of this protein?
Anti-sigma-L factor RslA, Regulator of SigL, Sigma-L anti-sigma factor RslA.
What is the protein family that this protein belongs to?
Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RBSD_VIBPA
Sequence: MKKSTLINSGISYLVATLGHTDEITICDAGLPIPDHVQRIDLALTHGVPSFLDTVRVILSESQIEGVIIAEEFSDVSPVLHEALLKELSKESEETGKSIEIKYVSHEAFKARTEQSRAVVRTGECTPYANVIFQAGVVF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.