PharMolix/UniProtQA huggingface dataset:
Protein: GRK5_MOUSE
Sequence: MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYYSLCDKQPIGRLLFRQFCETRPGLECYIQFLDLVAEYEITPDENLGAKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEKKLLQSPCKELFSACAQSVHDYLKGDPFHEYLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSSKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQNEMIETECFKELNVFGPNGTLSPDLNRSQPPEPPKKGLFHRLFRRQHQSNSKSSPTPKTSCNHRINSNHINSNSTGSS
What is the function of this protein?
Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs).  Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.  Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors.  In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1.  Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors.  Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription.  Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis.  Phosphorylation of ST13 regulates internalization of the chemokine receptor.  Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
What are the official names of this protein?
G protein-coupled receptor kinase 5, G protein-coupled receptor kinase GRK5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane, targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion (By similarity).
Protein: RELA_ECOL6
Sequence: MVAVRSAHINKAGEFDPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMVEILSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKSVVNLIHGVRDMAAIRQLKATHTDSVSSEQVDNVRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAKLLHERRLDREHYIEEFVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTVEIQIRTKQMHEDAELGVAAHWKYKEGAAAGGARSGHEDRIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKEAEKHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFLQSQFNKPSAEEQDAAALKQLQQKSYTPQNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCEQLAELRSHAPERIVDAVWGESYSAGYSLVVRVVANDRSGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGKLNQVPDVIDARRLHGS
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.  This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity).
What are the official names of this protein?
GTP pyrophosphokinase, (p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: RBSD_LACPL
Sequence: MKKTKVINSDLSRVIATMGHFDKLSIGDAGMPVPSSTEKIDLAVDNGIPSFMQVLNNVLEELEVQRIYLAEEIKVQNPKMLTAIKKRLPDTPITFIPHEEMKKDLADCKAFVRTGEMTPYSNILLESGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URK_STRPZ
Sequence: MLKKPIIIGVTGGSGGGKTSVSRAILDSFPNARIAMIQHDSYYKDQSHMSFEERVKTNYDHPLAFDTDFMIQQLKELLAGRPVDIPIYDYKKHTRSNTTFRQDPQDVIIVEGILVLEDERLRDLMDIKLFVDTDDDIRIIRRIKRDMMERGRSLESIIDQYTSVVKPMYHQFIEPSKRYADIVIPEGVSNVVAIDVINSKIASILGEV
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM36_DANRE
Sequence: MLLRSLVGSLTRQWSQFARCAASLSLPAVGAQRCLSTITAAAVPFRAVVNPMFKPHTAFLSPLLGRCQQLLCVQPSAGMKTKSALKKRCNECFFVRRRGRLFVFCKAHPRHKQRQG
What are the official names of this protein?
39S ribosomal protein L36, mitochondrial, L36mt, MRP-L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: EMC2_MOUSE
Sequence: MAKVTERYDVTWEEMRDKMRKWREENSRNSEQIMEVGEELINDYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKTVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKMKKDNIKYASWAANQINRAYQFAGRSKKETKYSLKAVEDMLETLQITQS
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues.  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices.  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.  By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.
What are the official names of this protein?
ER membrane protein complex subunit 2, Tetratricopeptide repeat protein 35, TPR repeat protein 35.
What is the protein family that this protein belongs to?
Belongs to the EMC2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=May also localize to the nuclear envelope.
Protein: IOLG_BURO0
Sequence: MTLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVNDIDPQQARDAVTKYGLDAEIYADGHEVVAAAEVQAVLVTSWGPTHEAFVLDAIAHGKPVFCEKPLAVTADGCMRIVEAEVAHGKRLVQVGFMRPYDEGYRALKRVIDSGQIGAPLMLHCAHRNQSVGERYTTDMAITDTLIHELDVLRWLLGEDYASAQVVYPKKTHHASAHLADPQIVLLETASGVRIDVEIFVNCQYGYDIQCEVVGEQGIAKLPDPPAVGLKHAARQSVEIMTDWKERFIASYDVELQAFIDGVRQGALTGPSAWDGYAAAVAADACVRAQKSGAVEAIAMAERPAFYRG
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
What are the official names of this protein?
Inositol 2-dehydrogenase, Myo-inositol 2-dehydrogenase, MI 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: BGAL3_ORYSJ
Sequence: MAGASSYFSLRRLLLLLLPLVPLLGATTAAAAGANSSVTYDHRSLIISGRRRLLISTSIHYPRSVPEMWPKLVAEAKDGGADCVETYVFWNGHEPAQGQYYFEERFDLVRFAKIVKDAGLYMILRIGPFVAAEWTFGGVPVWLHYAPGTVFRTNNEPFKSHMKRFTTYIVDMMKKEQFFASQGGHIILAQVENEYGDMEQAYGAGAKPYAMWAASMALAQNTGVPWIMCQQYDAPDPVINTCNSFYCDQFKPNSPTKPKFWTENWPGWFQTFGESNPHRPPEDVAFSVARFFGKGGSLQNYYVYHGGTNFGRTTGGPFITTSYDYDAPIDEYGLRRLPKWAHLRDLHKSIKLGEHTLLYGNSSFVSLGPQQEADVYTDQSGGCVAFLSNVDSEKDKVVTFQSRSYDLPAWSVSILPDCKNVAFNTAKVRSQTLMMDMVPANLESSKVDGWSIFREKYGIWGNIDLVRNGFVDHINTTKDSTDYLWYTTSFDVDGSHLAGGNHVLHIESKGHAVQAFLNNELIGSAYGNGSKSNFSVEMPVNLRAGKNKLSLLSMTVGLQNGGPMYEWAGAGITSVKISGMENRIIDLSSNKWEYKIGLEGEYYSLFKADKGKDIRWMPQSEPPKNQPMTWYKVNVDVPQGDDPVGLDMQSMGKGLAWLNGNAIGRYWPRISPVSDRCTSSCDYRGTFSPNKCRRGCGQPTQRWYHVPRSWFHPSGNTLVIFEEKGGDPTKITFSRRTVASVCSFVSEHYPSIDLESWDRNTQNDGRDAAKVQLSCPKGKSISSVKFVSFGNPSGTCRSYQQGSCHHPNSISVVEKACLNMNGCTVSLSDEGFGEDLCPGVTKTLAIEADCS
What are the official names of this protein?
Beta-galactosidase 3, Lactase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: RINI_RAT
Sequence: MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRTNELGDAGVGLVLQGLQNPTCKIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLASVLRVKPDFKELVLSNNDFHEAGIHTLCQGLKDSACQLESLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTGIAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKTCSLTAASCPHFCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTVLRVLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDNGVLQLLESLKQPSCILQQLVLYDIYWTDEVEDQLRALEEERPSLRIIS
What is the function of this protein?
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG.  May play a role in redox homeostasis.
What are the official names of this protein?
Ribonuclease inhibitor, Ribonuclease/angiogenin inhibitor 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSB_KLEP3
Sequence: MLHTLSVSPWHADIAAMLRVMDHGDDLLLLSDGVTAAIAGGRFLEILQSAPITLYVLQDDVDARGLAGQIADSVGRVSYTDFVRLTVKHAGQLAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_UREU1
Sequence: MSSFIDITNVISSHVEANLPAVSAENVQSLANGAGIAYLGKYIGTGITMLAAGAVGLMQGFSTANAVQAVARNPEAQPKILSTMIVGLALAEAVAIYALIVSILIIFVA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSBQ_ORYSJ
Sequence: MAQAMASMTGLSQGVQLPAGPRRAGGRSRLAVVRADAAAADVQTGRRAVLGLVATGIAGGALAQAALAEAAKPIKLGPPPPPSGGLPGTLNSDQARDTDLPLRERFYLQPLPPAEAAARAKESAQDIINLKPLIEKKQWPFVRDDLRLRASYLRYDLKTVINSKPKDEKKGLKDLTGKLFATIDGLDHAAKIKSPEEAEKYYTLTKSALGDVLAKLG
What are the official names of this protein?
Oxygen-evolving enhancer protein 3, chloroplastic, OEE3, LP02.
What is the protein family that this protein belongs to?
Belongs to the psbQ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: RIMP_STRT2
Sequence: MCKEVIMSQKIIDLVTAVVAPAIPDPYELVDIEYEKIGSDYILSVLIDKPGGITVEDTADLTEIISPLLDTIQPDPFPDQYMLEVSSPGLERPLKTKEALKNAVGQYINVSLYKAIDKIKIFQGDLLAFDGETLTIDYLDKTRHKTVEIPYQTVAKARLAVKL
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IPDC_MYCTU
Sequence: MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASATMTLDELAAAITKVKAVTDKPFGVNIRADAADAGDRVELMIREGVRVASFALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGGHTGPVATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGVAMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVEKLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQVLMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDAITHLQTASALVE
What is the function of this protein?
Involved in the final steps of cholesterol and steroid degradation (PubMed:28377529).  Probably catalyzes the introduction of a double bound into the C ring of 5OH-HIC-CoA, leading to the formation of (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA (Probable).
What are the official names of this protein?
(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA dehydrogenase, 5OH-HIC-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the nitronate monooxygenase family.
Protein: XERD_VIBCH
Sequence: MSEALSPDQGLVEQFLDTMWFERGLAENTVASYRNDLSKLLEWMAQNQYRLDFISFAGLQEYQSWLSEQNYKPTSKARMLSAIRRLFQYLHREKVRADDPSALLVSPKLPTRLPKDLSEAQVEALLSAPDPQSPLELRDKAMLELLYATGLRVTELVSLTMENMSLRQGVVRVMGKGGKERLVPMGENAIEWIETFLQQGRSLLLGEQTSDIVFPSSRGQQMTRQTFWHRIKHYAVIAGIDVEKLSPHVLRHAFATHLLNYGADLRVVQMLLGHSDLSTTQIYTHVATERLKQLHNEHHPRA
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids (By similarity).
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NO44_SOYBN
Sequence: MEEKILMRVIVITVFLFIGAATAEDAAAEAYESPKLKKLITDCTGHVGETCSTTTSSSGSEALMQKQDGLALCLLDSMERCLLDHQTNVGTLGDLIILPPFPPRPPVDPNIIPFPRPPNIVPFSPRGRRSKLDNHQTDAGTLGKVIPLPPIRPGPPLKIIPFPGTNIVPFPRPPNIVPFPRRRRSKLDNHQTDAGTLGDLIILPPFPPRPPVDPNIIPFPRPPNIVPFSPRGRRSKLDNHQTDAGTLGRVIPLPPIRPGPPLKIIPFPGTNIVPFPKPYIPHSYNTITNLLGARRDQVQDLPLLIQTTQLRTVLGICSHVTARTCLTAPNVATSDLEACLTPSMNQCVYPPGAESGSPPI
What are the official names of this protein?
Nodulin-44, N-44, Nodulin E27.
What is the protein family that this protein belongs to?
Belongs to the nodulin 20 family.
Protein: AIP11_ARATH
Sequence: MAKLLETFPCVPSTERGRGILISGDSKSDTILYCNGRSVFIRSLRQLQDVQVYGEHGYAVTVARYSPNGEWIASADVSGTVRVWGTHNGFVLKNEFRVLAGRVDDLQWSFDGLRIVASGDGKGKSLVRSFAWDSGNTMGDFDGHSRRVLSCAFKPTRPFRIATCGEDFLVNFYDGPPFKFHSSHREHSNFVNCIRYSPDGTKFITVSSDKKGMIYDGKTGDKVGELASEDGHKGSIYAVSWSPDSKRVLTVSADKSAKVWEVAEDGTIGSVIKTLSFMESGGAEDMLVGCLWQNDHLITVSLGGTMSLFSADDMDKPPLLLSGHIKNVTSLAVLGENQKTILSCSYDGLIVKWLKGVGYSCKLQMKDTKIKRLAATESSIFISGYDNMVWRIPLTDNGYGAAEHVDIGHQPLDISIAVDSPEATALVSFDSGVVLLNGLNILSKIDLGFAVAASVISPDGKEAIVGGQDGKLHIYSVSGDNNLKEEAVLEKHRGALTVIRYSPDLTMFASGDANREAVVWDRETKQVKLNNMLFHTARINSLAWSPNNKMVATGSIDTCVIVYEVDKPASSRITARNAHLGGVNAVAFIDDCTVASSGEDASVRLWHIEPQ
What is the function of this protein?
Binds actin.  Enhances the F-actin depolymerization activity of actin-depolymerizing factor (ADF) proteins.
What are the official names of this protein?
Actin-interacting protein 1-1.
Protein: MURG_STRPJ
Sequence: MKKIVFTGGGTVGHVTLNLLLMPKFIEDGWEVHYIGDKRGIEHQEILKSGLDVTFHSIATGKLRRYFSWQNMLDVFKVGWGIVQSLFIMLRLRPQILFSKGGFVSVPPVIAARVSGVPVFIHESDLSMGLANKIAYKFATKMYSTFEQASSLSKVEHVGAVTKVSDQKNPEPDELVDIQTHFNHKLPTVLFVGGSAGARVFNQLVTDHKKELTERYNIINLTGDSSLNELSQNLFRVDYVTDLYQPLLELADIVVTRGGANTIFELLAIAKLHVIVPLGREASRGDQIENAAYFVKKGYAEDLQESDLTLDSLEEKLSHLLSHKEDYQAKMKASKELKSLADFYQLLKKDLS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NEP_I87A1
Sequence: MDSNTVSSFQDILMRMSKMQLGSSSEDLNGMITQFESLRLYRDSLGEAVMRMGDLHSLQSRNGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: C3H39_ARATH
Sequence: MDSSYSDSRPMFVQSPYGGWNQTQMIDSMANPMNNEQGDLHSLSESQSQSQPSQQLQPALKRPRLVDDNLFNPASSFPQPSSSNPWMVPSLNPPPVNKGTANIFYKTRMCAKFRAGTCRNGELCNFAHGIEDLRQPPSNWQEIVGPPPAGQDRERERERERERERPSLAPVVNNNWEDDQKIILRMKLCRKFCFGEECPYGDRCNFIHEDLSKFREDSGKLRESSVISVGATAADQPSDTASNLIEVNRQGSIPVPAPMNNGGVVKTVYWKTRLCMKFDITGQCPFGDKCHFAHGQAELHNSVGRVEGEAMNAVASVNKQAVVPANEAFAMKPITQVTADSSGLNEEGRRKKCLLKWSDSKKINRIYGDWIDDLPVGQKSTKPVES
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 39, AtC3H39.
Protein: FBXW2_BOVIN
Sequence: MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKSLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYILDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
What are the official names of this protein?
F-box/WD repeat-containing protein 2, F-box and WD-40 domain-containing protein 2.
Protein: MMP18_XENLA
Sequence: MNSLLLKLLLCVAITAAFPADKQDEPPATKEEMAENYLKRFYSLGTDGGPVGRKKHIQPFTEKLEQMQKFFGLKVTGTLDPKTVEVMEKPRCGVYDVGQYSTVAKSSAWQKKDLTYRILNFTPDLPQADVETAIQRAFKVWSDVTPLTFTRIYNEVSDIEISFTAGDHKDNSPFDGSGGILAHAFQPGNGIGGDAHFDEDETWTKTSEIYNLFLVAAHEFGHSLGLSHSTDQGALMYPTYSNTDPKTFQLPQDDINAIQYLYGKSSNPVQPTGPSTPSRCDPNVVFNAVTTMRGELIFFVKRFLWRKHPQASEAELMFVQAFWPSLPTNIDAAYENPITEQILVFKGSKYTALDGFDVVQGYPRNIYSLGFPKTVKRIDAAVHIEQLGKTYFFAAKKYWSYDEDKKQMDKGFPKQISNDFPGIPDKIDAAFYYRGRLYFFIGRSQFEYNINSKRIVQVLRSNSWLGC
What is the function of this protein?
Cleaves collagen type I.  May play a role in larval tissue degeneration and adult organogenesis during amphibian metamorphosis.  May be involved in tail resorption.
What are the official names of this protein?
Matrix metalloproteinase-18, MMP-18, Collagenase-4, xCol4.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: 3S12B_MICPY
Sequence: LICYNDHGYIGETSESCKNGETTCYEEXWTEARXXIIERACGCXKVKPGVQMKCCKTQ
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Weak neurotoxin D2B.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: URE3_CORGL
Sequence: MHITPREQEKLMIVVAADLARRRKDRGLKLNHPEAVALITYELIEGARDGRTVADLMSWGSTILTRDDVLEGIPEMIPDIQVEATFDDGTKLVTVHNPIR
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_SHIF8
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP4_APRVF
Sequence: MQMEFKEELCDMFSQIWDHIPDSQNFSEEIIVDEKIETVPMDVPAIVTHSTNVKLLEEMDVEIVHGLNPIKTLMFDGINDDDEQGNVGETRDEGYYTVEPIDEFVKTKTVQTLKSLRRKRGVTSQDGADDTNKHDNMHMMLQNGHTSIQSIEIEHDNAVPLSGVVIDNILNKYGQDKIFNLRKHNQYGTIYHISDVNMLCEELICNATQLNLPAAAVRRITFEFCRWLNETELLKLQCNQLEKFVSVDSTEWFKLPVSLYFDIPIMAKLLNIPYNLIIIREGVLFQLLSLSDTTFELQQVEHLDFHTNQILAIIIDDHVTVPLLPLKKLWNISDLAKNTDLPLDLCEDVSSYFKEEDKAINTYITPYIDPRIIFIAHRNPTDFMFMLPNIPYLTEVNSEIQIDKLSDVCEFEYNRYRKALFCVENLIEIHRWHSLVCFIHLLANGELTQSEQIFIAGISRTNEYYVELSPRDCLYNTIRASFSAYQAWFKDWRANRKIQKIQNNGNDSLHTVIEVKSQQECPNIEQNTSINVNNLFFNTIIKYLDHEQHRFNFSDFNQQIAHGHFEALHASVEFVSEIQITREFCDVIRSNLPLNLDIISLYSKSLSDYLKMDLVVYFPEYNELRLIDATKQFKIRFIEFNCTKKTITMFKYTTTFHASMQKSYNYQVSISNGMSNKEMFITCFKKESNLAVVKQFSLRNNHRYDGIIDQPNIIGKGRPNYPNTKEQSVDHHPKISQVKHASVEQGHLINNYDLMKFALCHQNYKRIFNNQLFSEAPISDESLFRLKLEVNTGQHILAFTHVSFYEDGKVKTTYVTFITVDIDCSHVHQALLPRCVFHIQKGKPILYAANKTFVTGGSERRIEVVFNHLKEYIKETGIRSRDIHTLNSKSDQLITTCLTPFILSSMSMRKALQDNGDLSFTSQCVRKCQMSFKDDRINLPCGTSVHESTVDLHKHACLLEYYRLGLYKEKNNMNRCGFSCVECHSRYPNQLCANVCRLICQGM
What are the official names of this protein?
Putative non-structural protein 4, NS4.
Protein: RIMP_GLUOX
Sequence: MSQQNASSDIELPHLTGLEARIAERIAPTLADLGYELVRLSVLGRDTPTIQIMADRANGSLISVEDCEQISHAAGAILDVDDPIPGAWMLEVSSAGIDRPLTRAKDWERFAGHLAKAELDVPLNGRRRFSGTVMGARDGNAIIRLDDGTEAVLPLVDIRKARLVLTDALIEASAALAGVSSEGEDGGEARQAPKLNPKKPGKK
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.