PharMolix/UniProtQA huggingface dataset:
Protein: ISPH_NITEU
Sequence: MIRVLLANPRGFCAGVDRAIEIVERALAMYGAPIYVRHEVVHNRFVVEDLEKKGAVFVENLEEVPEGSMLIFSAHGVSHEVRREAAARKLQIFDATCPLVTKVHVEVAKMDKEGKEIVMIGHQGHPEVEGTMGQIAKSKGTMYLVETAEDVARLQVKNESNLAYVTQTTLSVDDAARVIEALKQRFPKIIGPKKDDICYATQNRQDAVKKLVKLCDLVVVVGSPNSSNSNRLCEVARNENVEAYMVDQAEQLQESWLTNKRCIGITAGASAPEILVQQVLERLEQIAAKQSNQGVIIEELSGVLESVTFPLPKAEPVSFNKYI
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PTH_CERSK
Sequence: MKLFVGLGNPGARYAGNRHNIGYMAVEAIAADHGFGPWRARFQGLTSEGRLGSEQVLLLKPETFMNLSGQSVGEAMRFYKLTPADVIVFHDELDLAPGKLRLKQGGGHAGHNGLRSIHAHVGEAYGRVRLGIGHPGHKDAVAAYVLNDFAKADQDWLADLLRGISDGAEALARGDGAKFQNAVALRMQPPKPEKPKPAAKAPEAQAPEAAPDARSALQKLADRFR
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE1_HPV59
Sequence: MADSEGTDGEGTGCNGWFFVQAIVDKKTGDKISDDEDENATDTGSDLVDFIDDTTTICVQAERETAQALFNVQEAQRDAREMHVLKRKFGCSIENSSEKAAAGKKAKSPLQEISVNVNHPKVKRRLITVPDSGYGYSEVEMLETQVTVENTGNGDSNGSVCSDSQIDCSDSSNMDVENIVPTSPTNQLLQLLHSKNKKAAMYAKFKELYGLSFQDLVRTFKSDRTTCSDWVTAIFGVNPTVAEGFKTLIQPYVLYAHIQCLDCAWGVVILALLRYKCGKNRITVAKGLSTLLHVPDTCMLIEPPKLRSGVAALYWYRTGMSNISEVIGETPEWIQRLTIIQHGVDDSVFDLSEMIQWAFDNDLTDESDIAYEYALIADSNSNAAAFLKSNCQAKYLKDCAVMCRHYKRAQKRQMSMSQWIKWRCDKIEEGGDWKPIVQFLRYQGVEFITFLCALKDFLKGTPKRNCIVLCGPANTGKSYFGMSLLHFLQGTVISHVNSNSHFWLEPLTDRKLAMLDDATDSCWTYFDTYMRNALDGNPISVDRKHRHLVQIKCPPMLITSNTNPVTDNRWPYLNSRLMVFKFPNKLPFDKNRNPVYTINDRNWKCFFERTWCRLDLNEEEEDADSDGHPFAAFKCVTGSNIRTL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: NAGB_SHEHH
Sequence: MQIVILKDSASVAEYGANIFIKQLQKKADSVLGLATGSTPLSLYQGLIAANKDKQISFKAVTTFNLDEYLGLEGTHPQSYRYFMNEQLFDHIDIDKSKTFVPPGDAENPIAACQGYEDKIKSAGGIDIQLLGIGRNGHIGFNEPSSGLMSRTRVKTLTKATIDDNARFFKEGEYQPHLSITMGIGTILDAKKVVLLATGENKAEAILATVEGALTAACPASALQLHQDAVLVIDEAAASKLTDRDFYKHIEVENQKLMARLGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: THIE_HALHL
Sequence: MNKQPSQLAGVYAVTQPRPDLQEAVAAVLRGGVGIVQYRDKSEDADRRREEAGALCRLCEEYGALFLVNDDVDLAAAVAAHGVHLGRDDGAVVAARQQLGDTAWIGVSCYDDLDRARRLVAEGADYVAFGSIFPSPTKPESGLAPMELLRSGREATGCPTVAIGGIDAGNIHEVAAAGADAAAVVSALFAAEDPEAAARQLVAQWQRSR
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: HIS3_CHLPM
Sequence: MGENEGIDKSFLDTVKFDDRGLIPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLKGESSGNMQEVFDILIDCDGDTLILKVSQIGGACHVGYHSCFYRKVNEDGSMQICDTLMFNPEEVYGKKH
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNK_BACC0
Sequence: MGYYSLTEVTAVQYAKEHGYFEKKANVVCHEIGDGNLNYVFKLDDGEKSIIIKQALPYAKVVGESWPLSIKRATIESKALQIFAKYVPEYVPVVYSHDEELAVTVIEDLSRLTITRKGLIDGEEYPLLSQHIGHFLANVLFYTSDFGLQSEEKRVLEGTFVNPDLCKITEDLVFTDPFGHYDTNDYEPELQLTIDELWSDKTLKLKVAQYKYKFLTRKEALIHGDLHTGSIFSSPSETKVIDPEFATYGPFGFDIGQLIANLLLNALSREEEQRGVLFFHIEKTWSYFVETFTKLWIGEGVEAYTKEKQWLPIILQNIFTDAVGFAGCELIRRTIGLAHVADLDEITNKETRIQAKKQALSLGKELIKYESKNADIQLFRTLFQQTVSGGIKA
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: RL5_PASMU
Sequence: MAKLHDYYRDQVVNELKDKFNYKSVMQVPRIEKITLNMGVGEALTDKKLLDNAVADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGQALLAAFNFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: TRMB_SHESA
Sequence: MSEVTTAEFNEEGKYLRKIRSFVLREGRLTKGQAQAIETQWPTMGLDYSPTPLNLTEVFGREADTVLEIGFGMGASLVQMAQEAPEQNFIGIEVHKPGVGSCLSDAAAAGVTNLRVYHHDAMEVLEHAIADGSLARVQLFFPDPWHKKRHHKRRIVQAEFAELIRRKLKIGGVFHMATDWENYSEHMLEVMNAANGYKNQSADGTVVPRPDHRPLTKFEARGHRLGHGVWDLMFERIA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: SNF1_CANGA
Sequence: MENKEHHHHHHHHHHHHSNGSYVSNKVSSLADGSRVGNYQIVKTLGEGSFGKVKLAYHVTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRNKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGASDLIKRMLIVNPLNRISIHEIMQDEWFKVDLAEYLVPQDLKQQEQFNKKSGNEENVEEIDDEMVVTLSKTMGYDKDEIYEALESSEDTPAYNEIRNAYILIKDNKSLIKDMKQDNNVTQELDTFLSQSPPTFQQNGDGMKASEDQKKKHSGRRLASSVTQQRTFHQPPFMDQSKEEDSTISILPTSLPQIHRANMLAQGLPAASKISPLVTKKSKTRWHFGIRSRSYPLDVMGEIYIALKNLGAEWAKPSEEDLWTIRVRWKYDSDESRLIEDGVKKIPNLMKIVIQLFQIETNNYLVDFKFDGWESTYGDSTISTNMSEDEMSTFSAYPFLHLTTKLIMELAVNSQGN
What is the function of this protein?
Essential for release from glucose repression.  It interacts and has functional relationship to the regulatory protein SNF4.  Could phosphorylate CAT8 (By similarity).
What are the official names of this protein?
Carbon catabolite-derepressing protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
What are the subcellular locations of this protein?
Nucleus membrane; Peripheral membrane protein.
Protein: HIS2_RUTMC
Sequence: MNDILIKLEQVLEQRKSAKVDESYISSLYNKGTDEILKKIAEESAEVIMAAKDGVNDKIIYEVADLWFHTLVLLRFKEIKVNQITNELSRRFGLSGLQEKAKRNN
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB_BORBR
Sequence: MKPYDLPDARGHFGPYGGVFVAETLMHALDELRAAYDQCRVDPSFIDEFNYELKHFVGRPSPVYHASRWSQRLGGAQIWFKREDLNHTGAHKVNNCIGQALLARRMGKPRVIAETGAGQHGVATATVAARYGMECVVFMGSEDVRRQASNVYRMKLLGATVVPVDSGSRTLKDALNEAMRDWVTNIENTFYIIGTVAGPDPYPRMVRDFQTVIGQECLTQMPEVIGRQPDYVVAAVGGGSNAMGIFHPYIPYENVRLIGVEAAGEGMETGRHAASLAAGQIGVLHGNRTYVMQNADGQVQETHSVSAGLDYPGVGPEHAWLKDSGRAEYAGITDDEALAAFHDCCRIEGIMPALESAHAIAQAVKMAPALSKDKVILVNLSGRGDKDMHTVAERAGLQL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: OST2B_ONCMY
Sequence: MKSLTLLTICAVLSVSLSMNDLALDVVLDPDPAAEPAPAADSSASSSASSSSSSASDSSASASDSSDSDSSSSSSSSSSSESASAEAMAEDPAAATEPEVIMKRDLASVLLRRKRAAGPAAAAFTLTQVESLSEVCELNLACEHMAETAGIVAAYTAYYGPPPF
What is the function of this protein?
Binds strongly to apatite and calcium.
What are the official names of this protein?
Osteocalcin 2b, OmyOC2b, Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein.
What is the protein family that this protein belongs to?
Belongs to the osteocalcin/matrix Gla protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS18_DELAS
Sequence: MATFKKFNKDKRPKRNTQSLLFKRKRFCRFTVAGVEEIDYKDVDTLRDFIGENGKIVPARLTGTRAIYQRQLNTAIKRARFLALVPYSDQHKI
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: GREA_MYCTU
Sequence: MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDLRENGGYHAAREEQGQQEARIRQLQDLLSNAKVGEAPKQSGVALPGSVVKVYYNGDKSDSETFLIATRQEGVSDGKLEVYSPNSPLGGALIDAKVGETRSYTVPNGSTVSVTLVSAEPYHS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RR11_ORYSJ
Sequence: MTKAIPKIGSRRKVRIGLRRNARFSLRKSARRITKGVIHVQASFNNTIITVTDPQGRVVFWSSAGTCGFKSSRKASPYAGQRTAVDAIRTVGLQRAEVMVKGAGSGRDAALRAIAKSGVRLSCIRDVTPMPHNGCRPPKKRRL
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AAEB_PECCP
Sequence: MKTPSLTGPVFFTTPKFARLRFAFKLSFAIVLSLFLGFHLQLETPRWSVLTAAIVAAGPAFAAGGEPFSGAIRHRGMLRVVGTFIGCIGALIIIIATVRAPVVMLMLCCIWAGLCTWVSSLVKVENAYVFGLAGYTTLIIIVSTQGTPLLTPQFAVERCSEIVLGIVCAILADLLFSPRSIKQDVDRSMGELLVDQYRLLQLSMSGAEKETIDAAWHALVRKTTALSGMRSSLMLESSRWQNSNRRLTSLHTQSLTMITQACETYLVLQDAPTPVKSSLKLVLDQPVESFRDVHCRVKALRHLIAADSRDVPPTLVSWVGAATRYLLLAKGVQTNGRITTIEADVLNSEVEIKAPSAETHHAMINGLRTGVATALGCLFWLSTGWTSGSVCMVMIAVVTSLAMRLPNPQMMAKDFLFGTIYALPLGALMFMFIMPSTQQSMLLLCLSLGAMAFFLGLEVQKRRLGSLGALASTINILVLDNPMTFHISQFLDSAIGQIIGCFLALMVILLIRDNTKAHTGRTLLNRFVYGAVSALTTNTTRRKENHLPALYQQLFLLLNRFPDDIAKYRLALWLIIMHQRLRTLDIPQNAALSAFHRQIRATAEQVILARRDTTRSRYFTQLLGELERYQQMLTEQQLPASVTAPVGRLTGILRDYQHALSN
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRCA_ACTP2
Sequence: MIKGVQITESSNSNLVNSFWLLDEEKNEARCIAAKGDVYKEDQVIAISELGQIAYREVPVNVAPTIKVEGGQHLNVNVLRRETLEDAVKNPEKYPQLTIRVSGYAVRFNSLTPEQQRDVITRTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: RHAR_YERPG
Sequence: MRAPLLLESRDYLLSEQMPVAVTNRYPQETFVEHTHQFCEIVIVWRGNGLHVLNDHPYRITCGDVFYIQAADHHSYESVHDLVLDNIIYCPERLHLNAQWHKLLPPLGPEQNQGYWRLTTQGMAQARPIIQQLAQESRKTDSWSIQLTEVLLLQLAIVLKRHRYRAEQAHLLPDGEQLDLIMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRFIRSPVLPAKNEP
What is the function of this protein?
Activates expression of the rhaSR operon in response to L-rhamnose.
What are the official names of this protein?
HTH-type transcriptional activator RhaR, L-rhamnose operon transcriptional activator RhaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 1A18_ARATH
Sequence: MGLLSKKASCNTHGQDSSYFWGWEEYEKNPYDEIKNPDGIIQMGLAENQLSFDLIESWLAKNPDAANFQREGQSIFRELALFQDYHGLPSFKNAMADFMSENRGNRVSFNPNKLVLTAGATPANETLMFCLADPGDAFLLPTPYYPGFDRDLKWRTGAEIVPIQCKSANGFRITKVALEEAYEQAQKLNLKVKGVLITNPSNPLGTTTTRTELNHLLDFISRKKIHLISDEIYSGTVFTNPGFISVMEVLKDRKLENTDVFDRVHIVYSLSKDLGLPGFRVGVIYSNDDFVVSAATKMSSFGLISSQTQYLLSALLSDKTFTKNYLEENQIRLKNRHKKLVSGLEAAGIECLKSNAGLFCWVDMRHLLKSNTFEAEIELWKKIVYEVKLNISPGSSCHCNEPGWFRVCFANLSEETLKVALDRLKRFVDGPSPTRRSQSEHQRLKNLRKMKVSNWVFRLSFHDREPEER
What is the function of this protein?
1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.
What are the official names of this protein?
1-aminocyclopropane-1-carboxylate synthase 8, ACC synthase 8, S-adenosyl-L-methionine methylthioadenosine-lyase 8.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: COX2_STRCO
Sequence: MSPNGSDRSPRRPMRRKLLQALTAGLVLATATGCTYEDFPRLGMPTPTTEEAPRILSLWQGSWAAALATGVLVWGLILWSVFFHRRSRTKVEVPPQTRYNLPIEALYTMVPLVIVSVLFYFTARDESDLMSLNKKPDLTVNVVGFQWSWCFNHIEDVPGSTGDAKTSKELAGIPDRFIEDFPANAGGVYDCGTPGTENPQTGNPGPTLWLPKGKTVRFVLTSRDVIHSFWVVPFLMKQDVIPGHTNAFEVTPNKEGTFLGKCAELCGVDHSRMLFNVKVVSPERYEQHLQDLAKKGQTGYVPAGIAQTSHEKNRETNNL
What is the function of this protein?
Subunits I and II form the functional core of the enzyme complex.  Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
What are the official names of this protein?
Probable cytochrome c oxidase subunit 2, Cytochrome aa3 subunit 2, Cytochrome c oxidase polypeptide II, Mtb92.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NRAM_I56A2
Sequence: MNPNQKIICISATGMTLSVVSLLVGIANLGLNIGLHYKVGDTPNVNIPNVNGTNSTTTIINNNTQNNFTNITNIIQSKGGERTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRMFALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSSTSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESECVCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSCYGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPNDPTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVPNAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRGRPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: OMT9_DICDI
Sequence: MDSGLSTPQLPITNMNNEITTDWDKAMNLIMTCVSGHIHSRMFNIVMKLNICDILEDGPKSIKQVSDTIGMDENSCFRLLRYFVAHELFSEDKSNIGTFEKTSISTMFSSKGKLRPMGERYTHDLHYKMFESLPETFANGHSNATKSVGVNHFWELFDLHPQYKDLFNQTMKVYTEAAISNITQSKGIDFSQYDTVVDIGGNHGLLIGNLLEIYPTIKHGINFDLDVVINSSDQTLRYSHPRLTHIPGNFFESVPESDCYIMKFILHDWPTQDCVKILKTISKSMKPNAKIHLFEIIIDPRKGYSKYETYIDILMFQMVNAKERTLDEWKELFELADFKLERVVDDIKTGCMVVSKK
What are the official names of this protein?
O-methyltransferase 9.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.
Protein: TRPB_STAEQ
Sequence: MKIQTEVDELGFFGEYGGQYVPETLMPAIIELKKAYEDAKSDTHFKKEFNYYLSEYVGRETPLTFAESYTKLLGGAKIYLKREDLNHTGAHKINNAIGQALLAKRMGKTKLVAETGAGQHGVASATIAALFDMDLIVFMGSEDIKRQQLNVFRMELLGAKVVSVSDGQGTLSDAVNKALQYWVNHVEDTHYLLGSALGPDPFPTMVRDFQSVIGNEIKSQILSKEGRLPDALVACVGGGSNSIGTFYPFIQDDVKLYGVEAAGKGSHTHNHALAIGKGKPGVLHGSKMYLIQNDDGQIELAHSISAGLDYPGIGPEHSYYNDIGRVSYVSATDNEAMEALITFSKVEGIIPAIESAHALSYVEKLAPNMDEKEIIVVTISGRGDKDMETIKQYKENGGEQNE
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: YVZB_BACSU
Sequence: MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLTVNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTINNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR
What are the official names of this protein?
Putative flagellin YvzB.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Bacterial flagellum.
Protein: MYG_LOXAF
Sequence: MGLSDGEWELVLKTWGKVEADIPGHGEFVLVRLFTGHPETLEKFDKFKHLKTEGEMKASEDLKKQGVTVLTALGGILKKKGHHEAEIQPLAQSHATKHKIPIKYLEFISDAIIHVLQSKHPAEFGADAQAAMKKALELFRNDIAAKYKELGFQG
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: COBQ_LISIN
Sequence: MVEQIMIQGTASDAGKSVIVAGLCRLFKNKGKRVVPFKSQNMSLNSFITATGDEMGRAQVFQAEAAGVFPDVRMNPVLLKPTNDRQSQVIFMGAILDNMDAVSYHDFKQTLIPKIQAVYQSLADENDIIVLEGAGSPAEINLNDRDIVNMGMAKMVDAPVVLVADIDKGGVFASIYGTIMLLKEEERARLKGVIINKFRGDVALLQPGIEMIEELTNVPVIGVIPYANLQLEEEDSVSLSGKNYVLDSSALLDIAIICLPRISNFTDFHILEIQPDISVRYIRNLADFGNPDLVIIPGSKNTLEDMAFLEQSGLKKAIQNYAENAGKVIGICGGYQMLGKRMLDPNQVESEKVEIAGLGLLDTETIFLDQKRTTQITGVTFSSEPVEGYEIHMGQTKRGENTQPFCKIKAVNGNQETHEDGAISANKNIIGTYIHGIFDNDIFLGNLFNELLTQKNKSIYPHEIIKLKEHKETEYDKLAALLEANIQMDQLEKIMKGEKICVSTQKPAIKE
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: GHRL_PIG
Sequence: MPSTGTICSLLLLSVLLMADLAMAGSSFLSPEHQKVQQRKESKKPAAKLKPRALEGWLGPEDSGEVEGTEDKLEIRFNAPCDVGIKLSGAQSDQHGQPLGKFLQDILWEEVTEAPADK
What is the function of this protein?
Obestatin may be the ligand for GPR39.  May have an appetite-reducing effect resulting in decreased food intake.  May reduce gastric emptying activity and jejunal motility (By similarity).
What are the official names of this protein?
Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide.
What is the protein family that this protein belongs to?
Belongs to the motilin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYE_METLZ
Sequence: MADADIRNDIYVLALENAVKHKAVPRAGAILGSVMGAHPELRSKAKEINALIPEILEEVAALSIEEREEKLMSLNPGAIEKMHEKKERSHELPDLPNAESGVVMRFAPNPSGPLHLGHARASVLNDYYVKKYGGKFYYRVEDTDPKRVDPSAYEMVSEDLAWLGIGITDVVYQSDRFAIYYEYARKLLELGGAYMCTCDNNEFREKKLKKIACPCREISVEENLKRFDDMLAGKYAEGEITLRVKTDIAHPDPAVRDFAAMRVLTSTPHPRKPAIFVYPLMNFSVAVDDHLLGMTHVIRGKDHIANTRRQEYIYNYFGWKMPYFYHYGRMSIAGLELSTSGMRKGINEGLYTGWDDIHLGTLRALARRGIQPEAVRAATIDIGMGDTDISFSWENLFAQNKAVIDAGADRYFFVPDAVEVEIAGAPKTEAHAPVYPNQPERGERVLPFTGRVLLPKSEMEKGGMLRLKDLFNINITGPNSAEYAGDSLAEARSQKAAIVQWLPTETAAPCSLLTPEGIQEGFSEPAVLGYLGRIVQFERVGFSKIDAVNDGKVIAYFTHR
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.