Protein: ATR_ASHGO
Sequence: MDGQTRYLDELVGALRAERAQGRAGGYAGEFPPREGGGRARRVARTVVAKLADAEVADAAFWRACEALDLVFTGRPMVLAEALDEEAGVLWAVRSCWRVAAVHFGRRERGWALRRASSRWVRLCADLYGQRWRARVGAELDRELCAGEAAVRAVLGGGQEAGEHMRALRALCVAAEWAVSREFWFVTGGAERVGLRLQRLARLARYIGDAVELPLAEYEEVQVRLLGVSVQAYLEPDRPGLGELRFALEQLQYFVRGKHLRREFAAWSRLLLRLYVRCRSDRAALLLVREVLVLDAAELPEAATDAQRSLQLVRYDLERQFAADHALRWDPALRAKLLAAGTPPVILEPFTSNRQLEKLRLRVLCDFQVGDSALLVHQFSAAGVPLGADPVALYTHLDEGIARAFGRQDTEAQVRYLSLVRKLACLESRKPSPGFDCDLCDHTNLWLPRESIDPSRPEAASDSLAFKLLVGYYLREQLESSGEALVIGILITLRSIFTHFQPPKLVENHYGDMVDEHGCIQLFRMAFMSLNRHVRILSVLLIPYWNLSRSYNADEQQTALIIKFLQRNPDPHITETYLMAWTQLTLSTSGELFDSLLLKLIDIFNSSNFVEHVVMASQLKFIARVLNKTAYQLLSPILPILLKQIGKNLGEKKLSLERLLNLLEYSAKTVIENFQRYIVPYALTQYKGDALTEIAKIMCQNNEPSMVSEQKKRLLDRNSRQIFAVALVKHGLFSLETIETLFINNDPTFDRSYVAGFLPDYKTLAEVLKLFKPVEKVDSPMNDNERAVLSSLRFLFLTNFSVDKHRGSKFKNVTEWTQEKEAVFQKKLKDNILGIFQVFSSDMHDIEGKTTYFEKLRVISGISFLIKYASKECIISALAQVSICLQTGLEIPEMRYNTLRCWLHLVKYLSEEELSTVIDVLICFILQKWDEFSGKIQQAAIDILDALILEKQTLLTNSRPYIVLAFLNKSELHIFENHGFFARTASKLLKNTNWVSVFVSNLKSHNIYVIKQTLQDIRLFLEKKQDAGIDIKLISKDGKNISELLGALLDTSHKYRNSDLIICETCALCISMIGVLDVTKHELQRCNVYDNDICDFNNPTQTTKFLINIINERLVPSFWQSENPTKQLFVALVIQESLKYCGLSASSWDVTKPDLYPNESKLWNRFNDISKTTLYPLLSSLYLAQSWKEYVPLSYPSFKVKDGYSTWIKNLSLDLLKTATESSHPLHVFSSLIREDDGTLSDYLLPYIIMDIIIKAESGTKYFDYLQNVIKDFEYIFNYTLYDLNHYQIDGLKMCYDSIFRVFEYCKKWVNQFRQNYSKQHGTFTIREEKYTRMLNRAGKFADIIPSHVLAQKSLETNSFERSALYLEQSYREKSSNGLQDDKLLPYLQTTYAEINDIDAVVGVLKVFCSNNLTSRIEELQYSDNWKMAQDCFDALGDSLLNEQGGVENSVPTSRMLKLMYDHQLYDQTLKKLELNIPSKKRQLPLNLDEFYNMGIETASLSGNITELKIWIRRIEQLETLTDPSILLHYNLAKSLLAVLEGKTDMIETHSKYCYRLIGSHFTTPSHSTTLLKRRNLFIKLHGIRDNSILSKCSTDIQFNRSVRNLAVRFKNVGSDFEPNFYLLSMRKSHNLMRSEEFVKQDLADTYFKMAQLARENDRLDIASDCLMHALKLEHTEAELEYAEILWKQGEKELALKTVAEIHQKRKGIKTLKDRDRAKVLLKYTEWLDLSNNATSVQISHQYKEVIGLDKDWDEPYYSFGLYYSRLLEKKRADGFVTTGSLEYKAITYFLSAFEKNTVKVREALPKVITFWLDTASRSVESGSSEGEYHFKRYTKEICKCIDVAIQNCPTHIWYTVLTQLLSRLLHKHTDSATLIMNILLKLTLEYPSIMLWYITVLLNSQENKRVHAGKQIMDAIKKRMPDKSSLISSAISLVQAMTRVCIKDVKNMSSRSGKSLQNDFKFDINLAPSEMVVPVNINLANLSPSYADTSGKHGSSKRVTINCFTPHYKVYSSLKKPKKINIIGSDGELYGIMCKKEDVRQDNQYMQFANMMVFLLGKDSESRRRSLNITTYAILSLREDCGLIEIVPNVDTIRSILMAKYDSMKIKYTLSVLYEKWKSVSEEQRLGFYKSCTDTFPPVLYQWFLETFPNPIRWYNARNAFVRSYAVMAMVGHILGLGDRHLENILLDLQTGKVLHVDFDCLFEKGKTLPVPEIVPFRLTQNIQDAFGVTGTEGTFKKSSEVTVRVMRNNELALVNIIETIMYDRNMDHSIQNALRVLRNKVRGIDPRDDLPLSVPGQVDTVVQQASSDENLAQMYIGWLPFW
What is the function of this protein?
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor.  Recognizes the substrate consensus sequence [ST]-Q.  Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination.  Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism.  Required for cell growth and meiotic recombination (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase MEC1, ATR homolog, DNA-damage checkpoint kinase MEC1, Mitosis entry checkpoint protein 1.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. ATM subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to nuclear DNA repair foci in response to DNA double strand breaks.