PharMolix/UniProtQA huggingface dataset:
Protein: Y9461_DICDI
Sequence: MMVPSLSTSISSPALFKNREGGEEGNDGGLEQLQNQVNDLGDLNFNEEGDYNNDQQPTNEEEGTADNELESLMSLVNDNNNNNNNTSGIDDDNNNDIDDNNNNNNNNNNNNNNNNNNKEGLNDLFISSINVSTLLNDLDQLSDTHSHASVSNQSSNGSVRRGYDIKTQRSVGTKGQGGSSGSSPRSNSLRVYRTFPYRGDHHFSWLNNIRDVDSSEDPNSCHNSNNNNKNNKNNQPSSTHDQTNINNNNNNNCNDNEKPIKPNSTNGIRHSRKYKGLQQLDFLGSNIILPQQQQPQPIEDNQQVVPQPFQVDAESNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNENNQHPINPVNTQNTQQNVTHSNNNNNNNNNNTAPPNQWSELIESLGYGSQSDEQKTFGSTLDDLNNANSCSDLKDLIVDGISINNETSPSQSQEITDFSKIDNLNKNININNNNNTDSQQPLPSIDVNFSHNNNNNNNDNDNNNNNNNNNNNNNNNNNNNNIQDIQIPYHQNDQDYNIQEGNDINNDNYEIRVSNNDDDNDSSNNNNNNNSKFQENLNLLNTGMGGRICKTDQKKQLSRTITFADPSSILSFFGSIPTDEDQNNNNNKNKNTTTTTTTTNTTTTTTTTTSASAAAQNKLDLLSSLSAGQSSGGVGGGNNVLNSSSTPAIKVNHQHKVTEQNRTSSKISLSTIFPKLPPFTNQQSPPTLSPSKYYYPLLQPEPTTLIRGFSSAADINKRGLKRAKKPMEMEDVYLTQYPLGDDQDSQIALFAIFDGHSGKGCAVAAKEIFPNILLKYIKSTKNENGGKPIYDMRGVFLNAFKEVDAQLSKFEYEGATATVCLVWRAGHQRFVQSANVGDSTAFLSYGNETLFLSKDHRATDPEEIQRIKNDGITLTEGQTRINGLMVSRALGDHFIKHLNCGLSGEPYVSPPISITPFHSHLIVASDGLWDVISGNRAMEIVKVQQTEEKMSNSLLQCAIGSIKAKDNISIIVVTLQ
What are the official names of this protein?
Probable protein phosphatase DDB_G0279461.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PP2C family.
Protein: DDX3Y_MOUSE
Sequence: MSQVAAESTAGLDQQFVGLDLKSSDNQNGGGNTESKGRYIPPHLRNRETSKGVCDKDSSGWSCSKDKDAYSSFGSRDSRGKPNYFSDRGSGSRGRFDDHGRNDYDGIGGRDRTGFGKFERSGHSRWSDRSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIENFSDIEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEALKAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADTVQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEELDKRSFLLDLLNATGKDSLTLVFVETKKGADSLENFLFQERYACTSIHGDRSQKDREEALHQFRSGRKPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNLNITKDLLDLLVEAKQEVPSWLESMAYEHHYKGSSRGRSKSRFSGGFGARDYRQSSGSANAGFNSNRANSSRSSGSSHNRGFGGGGYGGFYNNDGYGGNYNSQAVDWWGN
What is the function of this protein?
Probable ATP-dependent RNA helicase.  During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (PubMed:30475900).
What are the official names of this protein?
ATP-dependent RNA helicase DDX3Y, D1Pas1-related sequence 1, DEAD box protein 3, Y-chromosomal, DEAD-box RNA helicase DEAD2, mDEAD2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
Protein: PTH_HALSA
Sequence: MKQVIAARTDIGMGQGKLAAQVAHASLNAYEYTDDRAVRRWKDEGQTKVVVKVGSERELYERSEEAKRAGLPTGLISDAGRTQLEPGTPTALAIGPAPDADVDQITGDLSLF
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_METFK
Sequence: MRGRFITLEGMDGAGKSSHIESIVSVLEGRGLEVVSTREPGGTPLGEKLRELLLHERMHVETETLLMFAARREHIAEVIEPALARGAWVVSDRFTDASFAYQCGGRGVPCEKVEALEAWVHPDLQPDLTLLFDVPVEISVARLAAARTPDKFERESAEFFRRIRNGYLARAEAQPQRFRLIDGNRPMDTVRKEVLDIMREFKA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RF1_EHRRG
Sequence: MSFDSGLEELSEKFYKLKHLLEDPSQLSVESFVNASKEYSELLPIISVIDEYNAVQKDIKDLQELINNQETDTELKNLAKEEFYELQKQLPKVKHKLKLSLLPKDKDDARNAILEIRAGTGGEEAALFVTDLYRMYIKYAEKKNWKIEQINSSSTGIGGHKEVSLCVSGSNVFAKLKFESGVHRVQRVPETEASGRLHTSAATVAVLPEIEEVDLKIDEKDLRIDVYRSSGPGGQSVNTTDSAVRITHIPSGIVVIQQDEKSQHKNKNKALKVLRARLYDLEKQKRDAEISQLRKSQIGSGDRSERIRTYNFPQSRITDHRINLTLYRLEDIMKEGDLDELIEALIAEDEANKLKNLNI
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYC_PTEHP
Sequence: MPLNVSFASRNYDLDYDSVQPYFYCDEEENFYHQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAAFASFSPRDDDDGGGGSFSSADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDGGSRSPARGHSACSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKPCASPDSTAFSPSSDSLLSSAASSPRASPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQPPAKRSESGSPSAGSHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPPTKRAKLDSGRVLKQISNNRKCASPRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILAIQAEEQKLISEKDLLRKRREQLKHKLEQLRNSCA
What is the function of this protein?
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.  Activates the transcription of growth-related genes.  Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis.  Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells.  Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).  Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
What are the official names of this protein?
Myc proto-oncogene protein, Proto-oncogene c-Myc, Transcription factor p64.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus.
Protein: RHAT_YERPA
Sequence: MNNAIILGIIWHLVGAASAACFYAPFKQVKKWSWETMWSIGGLVSWLILPWTVSYLLLPDFWQYYGSFSIATLLPVFLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIIGTLMTPILQGRFDVLLGTPGGRMTLLGVFVALIGVAIVSYAGLLKERAMGIQAEEFNLKKGLILAVMCGIFSAGMSFAMDAAKPMHEAASALGINSLYVALPSYVIIMGGGAIINLSYCFIRLATLKNLSVKADFSVAKPLLITNILFSALAGLMWYLQFFYAWGHAKIPQQYDYMSWMLHMSFYVLCGGIVGLLLKEWKCSTKKPVAVLCIGCLVIILAANIVGLGMAA
What is the function of this protein?
Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).
What are the official names of this protein?
L-rhamnose-proton symporter, L-rhamnose-H(+) transport protein.
What is the protein family that this protein belongs to?
Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NFI_STRAW
Sequence: MTTVRIPAGWPATEEEARAVQDELRGRVILDEPGPPPGTGRVTGVDVAYDDERDVVVAAAVVLDAATLDVVAEATAVGEVSFPYVPGLLAFREIPTVLAALDALPCPPGLIVCDGYGVAHPRRFGLASHLGVLTGLPTIGVAKNPFTFSYEDPGAPRGSAAPLLAGADEVGRALRTQSGVKPVFVSVGHRVDLDHACAHTLALTPKYRIPETTRRADSLCRRALKEATA
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BR1_ODOSH
Sequence: MFTLKKSLLLLFFLGTINLSLCEEERNAEEERRDDPEERDVEVEKRFFPAILRVAAKVGPAVLCAITKKC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Brevinin-1S.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: RAB1A_HUMAN
Sequence: MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626).  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626).  RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926).  Required to modulate the compacted morphology of the Golgi (PubMed:26209634).  Regulates the level of CASR present at the cell membrane (PubMed:20861236).  Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577).  Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626).  Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).
What are the official names of this protein?
Ras-related protein Rab-1A, YPT1-related protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome. Note=Alternates between membrane- associated and cytosolic forms.
Protein: ASSY_DICCH
Sequence: EFLNSSVKIVNPIMGVKFWDENVRIPAEEVTVRFERGHPVALNGQTFSDDVELLLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLVTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDPQALMLRDALQRWVASEITGEVTLELRRGNDYSILNTVSDNLTYKPERLTMEKGESVFSPDDRIGQLTMRNLDITDTREKLFNYVESGLISSGNAGLPQVANPLLQDKSAK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM30_YEAST
Sequence: MTKRRNLFMVGSSFTIDHLPPEIWLCISKLVGTSDLHNLCLINRRLYLTITSDEIWKRRCYDRWINRESLDILTGNDYDSIPVSQWYSYYLRRAKWENKIFCLLWGLTEETNPQHFREKYLHILQFRHYKLATFLHRIIKQGYIPDKRPLDLITYANYLLKNVRHKYVFPLFYPTNAAELKNLNNMASRDAEMIYLRLSAIDTSFDDLLDAREFILNGICSDLLQKYKKIEEFLKLRPVTRVSKLISISTDYLDCFTQPHDSVGQTNDRATGRELHREDFMLLRVYSREGRGYKTIILAIIQAITKRYNVDSYLARDHLVVSEPDFPDGRAFVTVNEDFQPYIFDKEDLLSVWSNNFHNAENFESTVLPALLEPISIQHLLTEFFRELLRCKPRPFEGYPNRAHGLRDMFPYGKVEVPRDVTMYFAFIYDLFDGMFESGMTSLRGQMLRDLLNYVNANNFGDLNIIIGQNALKEPNDCWSNKRDYVLLDDNNKIGYFYTDIETEDTLCALNQYEVDGKVFITTIDILGDIRVRLAEGLTPFQGDNDKLWESFSSVVPRTDWGLFFKGYDKERRRMQLNPYIEEKLSNLANDEQPLHNL
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Probably recognizes and binds to phosphorylated target proteins (By similarity).  Recognizes FZO1 and regulates the amount of FZO1.  Regulatory factor for the mitochondrial fusion machinery.  Required for mitochondrial DNA maintenance.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 30.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: GBRG2_RAT
Sequence: MSSPNTWSTGSTVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2561970).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).  The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity).  Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cytoplasmic vesicle membrane.
Protein: NCPP_SACS2
Sequence: MVTIALGSKNPVKISATKEALEILRLNWDLIATDIDSGVDKQPFCDQTYVGARNRALNAIKATNADIGLGIEGGVCNVYGKFIANAVVYVITKEGVENFAISSSFTLPSSIVSLILQGKELGEASDIIFKTINSKTKEGAVGLLTNNIIDRKTLYVQPIILALYPIYNTIINNTLF
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Probable inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: Y329_YERPA
Sequence: MNLQHHFLIAMPSLQDPQFKRSVIYICEHGEKGAMGLVINKPLEQLTVETILEKLKIKSPSRDPAIRLDNVVLAGGPLAEDRGFILHSPQEGFASSIHISPETMITTSKDVLETLGTSGQPKNLLVALGYASWRQGQLEQELLDNVWLTTEADTHILFNTPIAERWQAAANKLGINIFNIAPQAGHA
What are the official names of this protein?
UPF0301 protein YPA_0329.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: RPOB_SYNS9
Sequence: MSSSAIQVAKTATFLPDLVEVQRASFKWFLDKGLIEELESFSPITDYTGKLELHFIGSEYRLKRPRHDVEEAKRRDATFASQMYVTCRLVNKETGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEMDKNGRRTYNASVIPNRGAWLKFETDKNDLLHVRVDKTRKINAHVLMRAMGLSDNDVLDKLRHPEFYKKSIDAANDEGISSEDQALLELYKKLRPGEPPSVSGGQQLLQTRFFDAKRYDLGRVGRYKINKKLRLTIPDTVRTLTHEDVLSTLDYLINLELDVGGASLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPLVAAIKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHARVNEYGFIETPFWKVENGVVIKSGDPIYLSADREDEVRVAPGDVATEDNGEIKADLIPVRYRQDFEKVPPEQVDYVALSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERALVGTGLETQVARDSGMVPISRVNGTVVYVDANAIVVLDEDGQEHTHFLQKYQRSNQDTCLNQRPIVHQGDPVIVGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDALLVSERLVTDDLYTSVHIEKYEIEARQTKLGPEEITREIPNVAEESLGNLDEMGIIRVGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPGTERGRVVDVRIYTREQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLDCRVKIIPFDEMHGAEKSQQTVTTFLTEAAKLSGKDWVYNPENPGKLVLRDGRTGLPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIAVYTEEGKEVDLMQDVNPRRSTPSRPTYESLGVADYDED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: PCP1_SACS2
Sequence: MTVLLFGFEPFLEYKENPSQLIVEALNRSTILKEEVKGVILPVEYKKIEDVIVTKIRETKPILTLGIGLAPGRAKITPEKIAINYRYSREGDNAGKKYRGEKIDPLGQDGIFTNIPVEDLVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLGGFIHVPLHESYAARIQRSIPSMSLDTMIRGIKLSIEFILTNKNKKENLTLS
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase 1, 5-oxoprolyl-peptidase 1, Pyroglutamyl-peptidase I 1, PGP-I 1, Pyrase 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIB_SHEB2
Sequence: MTTNNLVLSGTITRSRRFKSPAGIAHSVIMLEHKSQRYEADMLRNVYVQIQVILSGPRFESVAEDLKAGVEVQVQGFMTLQQGRNGQNRLVIHAENVELKT
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: TSAD_BURO0
Sequence: MLVLGIESSCDETGLALYDTQRGLLAHALHSQIAMHRDYGGVVPELASRDHIRRALPLLEEVMAQSGTRRDDIDAIAFTQGPGLAGALLVGASIANALALAWNKPTVGIHHLEGHLLSPLLVDEPPPFPFVALLVSGGHTQLMRVTDVGVYETLGETLDDAAGEAFDKTAKLIGLGYPGGPEVSKLAETGTPGAVVLPRPMLHSGDLDFSFSGLKTAVLTQMKKFEAAKLDGEALERAKADLARGFVDAAVDVLVAKSLAALKKTKLKRLVVAGGVGANRQLRAALSAAAAKRGFDVHYPDLALCTDNGAMIALAGALRLGRWPEQANADYAFTVKPRWDLASLAG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
Protein: RL4_YERPY
Sequence: MELVMKDAPGALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARAGSVKSPIWRSGGVTFAAKPQDHSQKVNKKMYRGALKSILSELVRQDRLIIVEKFSVEAPKTKLLAQKLKDMALEDVLIVTGELDENLFLAARNLYKVDVRDVAGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PUR7_HAEIG
Sequence: MTQQLPILSLKKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPRKGEILTQISNFWFNKLAHIMPNHFTGDSVYDVLPKEEADLIRDRAVVCKRLNPIKIESIVRGYLTGSGLKDYKQTGTICGLKLPEGLVEASKLPEAIFTPSSKEEVGNHDINISYAECEKLIGADLAAQVKEKAIALYTVAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQAGTNPPSFDKQFVRDWLENSGWNKQAPVPKVPENIIQKTVDKYQEALDLLTK
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: IFNB_BOVIN
Sequence: MTYRCLLQMVLLLCFSTTALSRSYSLLRFQQRQSLKECQKLLGQLPSTSQHCLEARMDFQMPEEMKQEQQFQKEDAILVMYEVLQHIFGILTRDFSSTGWSETIIEDLLKELYWQMNRLQPIQKEIMQKQNSTTEDTIVPHLGKYYFNLMQYLESKEYDRCAWTVVQVQILTNVSFLMRLTGYVRD
What is the function of this protein?
Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli.  Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity).  Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.  Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor.  Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss.  IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity).
What are the official names of this protein?
Interferon beta, IFN-beta.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
Protein: MUTS_SHIF8
Sequence: MSAIENFDAHTPMMQQYLKLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRSNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAELQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESISPNAAATQVDGTQMSLLSVPEETSPAVEALENLDPDSLTPRQALEWIYRLKSLV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CYAY_HAES1
Sequence: MNIAEYHQNIEQVWLQIEEQLEEQGCDVDCDTQGSVFTITFADRSQIVVNKQEPLLELWLASKAGGFHFAFKNNQWIAQDGKLFWQCLEQACLAHGEQVSFS
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: CP4E1_DROME
Sequence: MWIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMKQRLVCDST
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 4e1, CYPIVE1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.