PharMolix/UniProtQA huggingface dataset:
Protein: SYP_SYNFM
Sequence: MRYSKYFIHTLFEVPKEAETPSHILLLRGCYIHPVAAGVYSLLPLGHRVAEKIKAILREELNAIEGLEVTMPVLNPAELWKKSSRYYDIGQELFRIKDRKDREFVLAMTHEEVITDIARQFLRSYRHLPVMLYQIQTKIRDEARPRAGLLRVREFFMNDAYSFHPDFADLDAYYPRIFNAYLRIFTRCGLTTVPIEADSGIMGGTGSHEFMLESPNGEDRFVVCTQCDYRANTEKAQGLIPPVKYSGDAPPPMEAVPTPGIKTIADLMRFFDCPEDRLLKTVAYEADGELVLAVIRGDFSVSATKLANHLKAVKVDFAPEKSLSARGLHAGFLSPVGLHGVKIVCDASVTGPAPFVAGGNAPDVHYRNVVCGRDFTPFDAADLAEVRDGDRCTRCAEGILRIRRGIELGHTFKLGTKYTAAESMDATYLDAAGNQQRVVMGCYGIGVERLMASAVEQWHDEGGMSFPYSIAPFQVILCSLGRKPEILEAAQALYERLGAHYDTIYDDRDESPGVKLKDADLLGVPIRVVVSQKLLQKGEVEIKVRRTGVVIVCPRDELLETLERIVADLQPSFEGLPFMPE
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_LEGPH
Sequence: MNKQDFYFDLPSELIAQYPLANRSDSRLLIYNRQTEEYGHYQFREIADFLQPGDLLVMNDSKVIPARLYGHKATGGKVELLVERITGDFTFLAHIKASKSLKSNDLIYLDAGKRLEVLQRQDDLFLCKACENILDLLNDLGHIPLPPYIAREDESLDKERYQTVYAKCAGSVAAPTAGLHFDDAVLSSIRARGVNIAYVTLHVGAGTFRPVRCERIQDHKMHSEWFTVSPDLCTAVKAAKSMGNRVIAVGTTALRSLESAAMGGELIPCSRDTDIFIYPGYQFKVCDGLITNFHLPESTLVMLVSAFIGHQECMALYQEAIDKRYRFFSYGDASLLL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL37_SPOFR
Sequence: MTKGTSSFGKRRNKTHTLCRRCGRSSYHIQKSKCAQCGYPAAKLRSYHWSVKAKRRKTTGTGRMRHLKIVRRRFRNGFKEGKPTPKKAVASS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
60S ribosomal protein L37.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL37 family.
Protein: GNAQ_CANLF
Sequence: MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.  Required for platelet activation.  Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity.  Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).  Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity).  Together with GNA11, required for heart development (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(q) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Golgi apparatus. Nucleus. Nucleus membrane. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Protein: TRPD_PYRIL
Sequence: MVNILKKLANGVSLNIDEAYLLSREILSGGLNDVAVAAALTAMRCRGETAEEVTGFVKSAREVAVKVPLRVEAIDTAGTGGDGAGTINLSTLAAVVAAAAGARVLKHGNRSASGFFGSADFMEAVGYNLEVGPEKAAEMVEKIGFAFVFAPRYHPAFAKVAPVRRQLPFRTVFNIVGPLANPGLVKRQLIGVSERRLLDVVGGVASVLLDRALVVYGSGVDEVSTEGPTEVVEVRGGRAERYVLEPEDFGIGKTPLPRASTREEAVGLALAGLRGEHREAEIAIAVNAAAALYVAEVVRDFRDGFELAVKTIREGAAYRKLREAVEASR
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: LEUC_BLOPB
Sequence: MGKSLYQKLYDAHIVHKNKDDVPILYIDRHLLHEVTSPQAFEALRLRKRIVRQPNKTFATMDHNVPTTTKNINHSGSMAKEQLDRLTKNCKDFGITLFGLNHPYQGIVHVLAPEQGITLPGMTIVCGDSHTATHGAFGALAFGIGTSEIEHVLATQTLQQIRYKSMQINLSGIIAPQITAKDIILAIIGKIGHGGGSGHVVEFCGPIITLLSMEERMTLCNMAIEMGATSALIAPDRTTYDYLKNRKFSPTGKNWEQALLYWKTLYSDHDAHFDKKFDFDVSNVNPQVTWGTNPSQVISIDQPIPSLESFIDPIERNSAERALIYMKLQSNTYLTDVSIDKVFIGSCTNSRIEDLRVAAQTIKGHHISKNTQAIVVPGSKLVKNQAEKEGLNKIFIQAGFEWRLPGCSMCLAMNNDRLEPGERCASTSNRNFEGRQGRGSRTHLVSPAMAAAAAIAGRFVDIRKFK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: GALT_BIFL2
Sequence: MNDQLTEVYASIDALIDYALAHLDLDPRNADWTRNQIFALFRLDSYPGPKTTTSAASVSDVVQDIVGSRSQAPYGEKTPDPLLAAFRAAATTAGLFKPEEGPAYADTIMGILSANPADLDDRFLLVEHRDGGMAAMQWFYDYCVANNYVKRAQLDRNPRFDSHGLTVTINLAKPEFKNMKKAAAGNAVAGGYPKCTICHENEGFAGRDKRTLRTLPVTLGGESWFWQFSPYGYFDQHGICVNTDHTPMHVDRDTFGHLLDFVDRFPGYFLGCNAALPRIGGSVLAHDHYQGGGELLPMHKAATWAAFTLADYPDAVVEILDWPGTAVRVVSKSRQSIIDVSDIIREAWVGYDDAANGIASHDADGNRQSALSPSAIITERGYEMSLIFRNNAISDEYPEGIFHAHPEYWPVKQEPIGLIEAQGLFILPGRLVDQLGIVEEALAEGRDLPDEVSEFSLEWGELAETLAGNHDREAIRQAVHDELGSVCYRILGNTAVFKQKATTQTFLESLGFAAR
What is the function of this protein?
Transfers the UMP unit from UDP-glucose (UDP-Glc) to Gal1P.  Can also transfer the UMP unit to GlcNAc1P and GalNAc1P.  Involved in the general galactose metabolism, and also involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria.
What are the official names of this protein?
Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_LEGPA
Sequence: MSAKIIRIATRQSPLALWQANHVREMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEEALLDKRADLAVHSTKDMPAQLPDGLSLAAICKRDNPFDALISPRFKSLDALPKNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIHGLNDPISALCVHTERRVNAKLGGNCHIPFAVYCTITAEKLLLLRAKVLNLDGSQMIDDEQQGKIEEAEIIADRCTESLMTKGAMSLLSTIPS
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: M1_I30A0
Sequence: MSLPTEVETYVLSIVPSGPLKDEVAQGLEGVFAGKNTDLEVLLEWLKTRPILSPLTKGILGFVFTLTVPGERGLQRRRFVQNALNGNGDPNNMDKAVKLYGKLKREITFHGAKEVALSYSAGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLVSTTAKAMEQMAGSSEQAAEAMEVASQARQMIQAMRTIGIHPSCGAGLKDDLLENLQAYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: NOB1_ARCFU
Sequence: MKCVEVHVIDSSAIFQRKAVYRNMVTVPEVVAEILDEASALYFSVKNFRVEEASPESVEEVKEAARKTGDIHKLSDTDIKVLAKALDEIKKGNEVVLVTDDYAIQNVAMSLGIRFDGILHRQISKEFKWVKVCRGCGRRIESEICPVCGSEAIIRRVKNDKNRNSG
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end (By similarity).
What are the official names of this protein?
Endoribonuclease Nob1, RNase Nob1, Endonuclease VapC8, Putative toxin VapC8.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: APAG_STRMK
Sequence: MEDADVYAISVEVAPRFLDDQSAPEDGRYAFAYTIRIHNQGRVAARLVARHWRITDANGRVEHVDGDGVIGEQPRLRPGEDFHYTSGVMLGTDHGTMQGHYDMVADDGTEFAAPVAPFVLAIPRTLH
What are the official names of this protein?
Protein ApaG.
Protein: PA2HK_TRIST
Sequence: SVIELGKMILQETGKNPVTHYGA
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks catalytic activity (By similarity).  Shows myotoxic activities (By similarity).  Induces local edema a few hours after injection (5-10 ug) in the hind paw (PubMed:12959640).
What are the official names of this protein?
Basic phospholipase A2 homolog CTs-K49c, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FOLB_STRP1
Sequence: MDKIVLEGCRFYGYHGAFKEEQTLGQIFLVDLELSVDLQAASLSDQLTDTVHYGMVFDSVRQLVEGEKFILIERLAGAICEQLFNEFPPIEAIKVAIKKENPPIAGHYKAVGIELERQR
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
What are the official names of this protein?
Dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin aldolase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: GCH1_BACFR
Sequence: MLEKEEIISPALEDLKNHYRSIITLLGEDAEREGLLKTPERVAKAMLTLTKGYHMDPHEVLRSAKFQEEYSQMVIVKDIDFFSLCEHHMLPFYGKAHVAYIPNGYITGLSKIARVVDIFSHRLQVQERMTLQIKECIQETLNPLGVMVVVEAKHMCMQMRGVEKQNSVTTTSDFTGAFNQAKTREEFMNLIRQR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: ESXC_STAAN
Sequence: MNFNDIETMVKSKFKDIKKHAEEIAHEIEVRSGYLRKAEQYKRLEFNLSIALDDVESTAKDVQTAKSSANKDSVSVKGKAPNTLYIEKRNLMKQKLEMLGEDIDKNKESLQKAKGIAGEKASEYFNKAMN
What are the official names of this protein?
ESAT-6 secretion system extracellular protein C, Ess extracellular protein C.
What is the protein family that this protein belongs to?
Belongs to the EsxC family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the ESAT-6 secretion system (Ess) / type VII secretion system (T7SS).
Protein: RF1_ALKMQ
Sequence: MLDKLAFLQEKYEDLGEKISDPEIINDQVQWQKLIKEHSEIEPIVMKYREYKTTQQALGETKEIMHDKATDAELKEMAKMEVEELEESIVEMEEQLKVMLLPTDPNDDKNVIVEIRGGAGGDEAGLFAAVLFRMYTRYAERSGWKVEMMSLNESGVGGYKEVIFMIKGKGAYSQLKYESGAHRVQRIPTTESGGRIHTSTATVVIMPEAEDVGEVNIDTNELRIDVFRSSGNGGQSVNTTDSAVRITHLPTGLVVSCQDGKSQLKNKEKAMKVLKSRLLDQMIQEQDAEISQDRRSKVGTGDRSERIRTYNFPQGRVTDHRINVTVYKLDAFLDGEINEMIDSLITSAQAEKMQEVQ
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPX_HV2RO
Sequence: MTDPRETVPPGNSGEETIGEAFAWLNRTVEAINREAVNHLPRELIFQVWQRSWRYWHDEQGMSESYTKYRYLCIIQKAVYMHVRKGCTCLGRGHGPGGWRPGPPPPPPPGLV
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells.  Targets specific host proteins for degradation by the 26S proteasome.  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1.  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1.  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein: GLPK_STRPB
Sequence: MSQEKYIMAIDQGTTSSRAIIFNQKGEKVSSSQKEFPQIFPHAGWVEHNANQIWNSVQSVIAGAFIESSIKPSQIEAIGITNQRETTVVWDKKTGVPIYNAIVWQSRQTAPIAEQLKQDGHTKMIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGELLFGTIDTWLVWKLTDGAVHVTDYSNAARTMLYNIKDLTWDDEILELLNIPKDMLPEVKSNSEIYGKTAAFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGDEMQLSSNNLLTTIGYGINGKVHYALEGSIFIAGSAIQWLRDGLKMIETSPESEQFALASTSDDEVYVVPAFTGLGAPYWDSNARGSVFGLTRGTSKEDFVKATLQSIAYQVRDVIDTMQVDSGIDIQQLRVDGGAAMNNMLMQFQADILGIDIARAKNLETTALGAAFLAGLAVGYWEDMDALKELNATGQLFKASMNESRKEKLYKGWKRAVKATQVFTQEEDADDDAK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: PFKA_TRYBO
Sequence: MDEPSNMSTTSSKIPQYDFYSDVDNLHPDQFRIQCLPGRNFISPLVEQKKDFVKAHVIHDKDLDIMYDPMPKGKCNISQSCLTLPLACPRVSLHFDPSKTTVAMVTCGGVCPGLNDVIRGITLAAVCSYHVKKVIGFKYGYWGLSKAGRHTAIELTSNIVRGLRHLGGTFLGTSRGGQNISDMVDTLVEYGVNILFTIGGDGTQKGAVAISEEVNRRGLDIAVFGIPKTIDNDLSFSQRTFGYETAVSEAVIAIRAAHAEAISHEYGVGIVKLMGRNSGFIAASATVASALSHICLIPEKNVSKKVLLSLIEARFMMAKDIVIVVAEGFGQDWPDCNEDLGSDASGNKRLTDIGLVIKKIVQDHLSKNPKYHQSTVKYIDPSYMIRACPASTSDAAFCSNLSTLAVHEAMAGRTACLITLWYSNFVLVPIKTAVSHRKIVSTGGALWRQVREVTVDGSGDIAMVHQQELSRELKAINAHRNSIMEQLSKL
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
What are the subcellular locations of this protein?
Glycosome.
Protein: RSMA_HAHCH
Sequence: MGRHNENIGHQARKRFGQNFLHDQGVIDRIVRSINPKSDQNLVEIGPGLGALTEELLKSGGSVTAVELDRDLTPILRTKFFNYPQFNVIEADALKFDFTQLATPERPMRLIGNLPYNISTPLIFHLLTFRGLVQDMYFMLQKEVVDRLAAKPGEDAYGRLGVMAQYYCKVESLFNVGPGAFQPAPKVWSAIVRLTPYTEPPLACKDVATLTTVVRQAFAMRRKTLRNTLKQLITVDALQSLDIDPQIRPERLGLPEFVRIADYVYDHPLENES
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAEX_SHIDS
Sequence: MSLFPVIVVFGLSFPPIFFELLLSLAIFWLVRRVLVPTGIYDFVWHPALFNTALYCCLFYLISRLFV
What are the official names of this protein?
Protein AaeX.
What is the protein family that this protein belongs to?
Belongs to the AaeX family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EX7L_KLEP3
Sequence: MLPSQSPAIFTVSRLNQTVRLLLEREMGQVWISGEISNFSQPSSGHWYFTLKDDNAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAQLTAEGLFEQKHKQALPSPAHCVGVITSKTGAALHDILHVLRRRDPGLPVIIYPTAVQGDDAPGQIVRAIALANARQECDVLIVGRGGGSLEDLWSFNDERVARAIFASQIPIVSAVGHETDVTIADFVADLRAPTPSAAAEIVSRNQQELLRQLQSGQQRLEMAMDYFLASRQRRFTQLFHRLQQQHPQLRLARQQTALERLRQRMRIAVESQLKRAEQRQKRTVQRLDHYNPQPRIHRAQSRIQQLEYRLAENMRGRLSERRERFGNAVTHLEAVSPLATLARGYSVTSVNDGTVLKQTKQVKTGDLLTTRLKDGWVESEVKQIAPVKKTRARKPSPTKPAE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9B_SCHPO
Sequence: MGRDIYKDETLTIPEGVSVDIKARLVTVKGPRGVLKQNLRRVDIELKKQGNTIKFIVWHGSRKHNACIRTAYSIINNMIIGVTQGFRYKMRLVYAHFPININLTENGTVVEIRNFLGERITRVIKCLPGVTVSISSAVKDEIIIEGNSLENVSQSAANIKQICNVRNKDIRKFLDGIYVSERGNIEELE
What are the official names of this protein?
60S ribosomal protein L9-B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: RL1_WOLTR
Sequence: MNIHSDSPRQCLEEIIKSASAKFNESIDIAVNLGIDSRKSEEQVRGTVVLPKGIGKDIKVAVFTQGKHLLEAEKAGANIVGGEDLVQEIKKGKKLDVDWCITTPDFIAKITPIAKILGAKGLMPNPKFGTMTSNVAEAIKTIKSGQIKFRTDKNGIIHGKLGNIKFSVDDLLKNLKAFLKVIKSNKPISVKGVYFKSVFLNSTMGKAYKMSKVEDII
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: MENC_ECOSM
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTREGLYVCLREGEREGWGEISPLPGFSQETWEEAQSVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELADTLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRHRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEKGVRAVVIKPTLTGSLDKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSPLPLVEVDALERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: PCSK9_RAT
Sequence: MGIRCSTWLRWPLSPQLLLLLLLCPTGSRAQDEDGDYEELMLALPSQEDSLVDEASHVATATFRRCSKEAWRLPGTYVVVLMEETQRLQVEQTAHRLQTWAARRGYVIKVLHVFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSLVFAQSIPWNLERIIPAWQQTEEDSSPDGSSQVEVYLLDTSIQSGHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNTACQRLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCYMSQSGTSQAAAHVAGIVAMMLNRDPALTLAELRQRLILFSTKDVINMAWFPEDQRVLTPNRVATLPPSTQETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDRIEAIGGQQVCKALNAFGGEGVYAVARCCLLPRVNCSIHNTPAARAGPQTPVHCHQKDHVLTGCSFHWEVENLRAQQQPLLRSRHQPGQCVGHQEASVHASCCHAPGLECKIKEHGIAGPAEQVTVACEAGWTLTGCNVLPGASLPLGAYSVDNVCVARIRDAGRADRTSEEATVAAAICCRSRPSAKASWVHQ
What is the function of this protein?
Crucial player in the regulation of plasma cholesterol homeostasis.  Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.  Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway.  May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.  Can induce ubiquitination of LDLR leading to its subsequent degradation.  Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner.  Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.  Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation.  Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 9, Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity).
Protein: RIMP_ECO7I
Sequence: MSTLEQKLTEMITAPVEALGFELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPLFTAEHYARFVGEEVTLVLRMAVQNRRKWQGVIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.