PharMolix/UniProtQA huggingface dataset:
Protein: CYOD_SHIFL
Sequence: MSHSTDHSGASHGSVKTYMTGFILSIILTVIPFWMVMTGAASPAVILGTILAMAVVQVLVHLVCFLHMNTKSDEGWNMTAFVFTVLIIAILVVGSIWIMWNLNYNMMMH
What is the function of this protein?
Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration.  Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity).
What are the official names of this protein?
Cytochrome bo(3) ubiquinol oxidase subunit 4, Cytochrome o ubiquinol oxidase subunit 4, Cytochrome o subunit 4, Oxidase bo(3) subunit 4, Ubiquinol oxidase chain D, Ubiquinol oxidase polypeptide IV, Ubiquinol oxidase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase bacterial subunit 4 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GABT_BACSU
Sequence: MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDLDGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGIAPGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKPYKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVMEPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDLITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLNERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAYANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA
What are the official names of this protein?
Probable 4-aminobutyrate aminotransferase, (S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, GABA-AT, Gamma-amino-N-butyrate transaminase, GABA transaminase, Glutamate:succinic semialdehyde transaminase, L-AIBAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: MUTL_SYNC1
Sequence: MSQKIHILPESLCNQIAAGEVVERPASVVKELVENALDAGASRIQVDVENGGKRLIRVTDNGCGMSREDAFLCLERHATSKVRAEQDLFRLTTLGFRGEALPSIAAVSRFTLRTRLAEDVEGWELVVEGGTVKRSSAAGVPPGTIIEIRNLFFNTPARRKFLRRDETELGHIGETLTRLALSCPEVCFRFMHNGRMLWEVNRQKSLVERAAELLGREAVRDMLPVERQGPEGMRLHGLISSPRLNRSGLGGMFTFINGRFIRDKVVQHALADGYRNLLAKGRHPVLVLFLEIDPSQVDVNVHPTKHEVRFRQQALVHDFIVKALRDHLQQVPTSAMPAPGNSPFTVPARENAASVKPDETKPALADTPAAFSAGEGSSRSDVPYPSASQVTETTDSYDAHDSGVEGASTAPPLSEEGLFSVTADVRPSEQTENSGFFASLRLIGQYQNSYLVCQSEKDLILIDQHAAHERIGFEHLRKQYLAGSIERQLLLFPLVLEFDFRLGRIVEEQRDSLFRLGFALENFGGNAFALKELPRMLKEADAERLVRDVVDEFAAIGRSQAVEIELERILLKMACHAMVRAHQRLSFDEMQALLDELDKTPFSSNCPHGRPTFLRWSLGELERLFKRA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: BBC1_YEAST
Sequence: MSEPEVPFKVVAQFPYKSDYEDDLNFEKDQEIIVTSVEDAEWYFGEYQDSNGDVIEGIFPKSFVAVQGSEVGKEAESSPNTGSTEQRTIQPEVEQKDLPEPISPETKKETLSGPVPVPAATVPVPAATVPVPAATAVSAQVQHDSSSGNGERKVPMDSPKLKARLSMFNQDITEQVPLPKSTHLDLENIPVKKTIVADAPKYYVPPGIPTNDTSNLERKKSLKENEKKIVPEPINRAQVESGRIETENDQLKKDLPQMSLKERIALLQEQQRLQAAREEELLRKKAKLEQEHERSAVNKNEPYTETEEAEENEKTEPKPEFTPETEHNEEPQMELLAHKEITKTSREADEGTNDIEKEQFLDEYTKENQKVEESQADEARGENVAEESEIGYGHEDREGDNDEEKEEEDSEENRRAALRERMAKLSGASRFGAPVGFNPFGMASGVGNKPSEEPKKKQHKEKEEEEPEQLQELPRAIPVMPFVDPSSNPFFRKSNLSEKNQPTETKTLDPHATTEHEQKQEHGTHAYHNLAAVDNAHPEYSDHDSDEDTDDHEFEDANDGLRKHSMVEQAFQIGNNESENVNSGEKIYPQEPPISHRTAEVSHDIENSSQNTTGNVLPVSSPQTRVARNGSINSLTKSISGENRRKSINEYHDTVSTNSSALTETAQDISMAAPAAPVLSKVSHPEDKVPPHPVPSAPSAPPVPSAPSVPSAPPVPPAPPALSAPSVPPVPPVPPVSSAPPALSAPSIPPVPPTPPAPPAPPAPLALPKHNEVEEHVKSSAPLPPVSEEYHPMPNTAPPLPRAPPVPPATFEFDSEPTATHSHTAPSPPPHQNVTASTPSMMSTQQRVPTSVLSGAEKESRTLPPHVPSLTNRPVDSFHESDTTPKVASIRRSTTHDVGEISNNVKIEFNAQERWWINKSAPPAISNLKLNFLMEIDDHFISKRLHQKWVVRDFYFLFENYSQLRFSLTFNSTSPEKTVTTLQERFPSPVETQSARILDEYAQRFNAKVVEKSHSLINSHIGAKNFVSQIVSEFKDEVIQPIGARTFGATILSYKPEEGIEQLMKSLQKIKPGDILVIRKAKFEAHKKIGKNEIINVGMDSAAPYSSVVTDYDFTKNKFRVIENHEGKIIQNSYKLSHMKSGKLKVFRIVARGYVGW
What is the function of this protein?
Involved in the regulation of actin cytoskeleton.
What are the official names of this protein?
Myosin tail region-interacting protein MTI1, Protein BBC1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, actin patch. Note=Colocalizes with cortical actin patches.
Protein: SSRP_KLEP3
Sequence: MTKKKAHKPGSATIALNKRARHEYFIEDEYEAGLALQGWEVKSLRAGKANIGDSYVILKDGEAFLFGANFTPMAVASTHYVCDPTRTRKLLLNQRELDTLYGRINREGYTVVALSLYWKNAWCKVKIGVAKGKKQHDKRTDLKDREWALDKARIMKHAGR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RMLA_SALAN
Sequence: MKTRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEEFIGNDDCALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHVNDPERYGVVEFDQSGTAVSLEEKPLQPKSNYAVTGLYFYDNSVVEMAKNLKPSARGELEITDINRIYMEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAYRKGFIDAEQIKNLAKPLSKNAYGQYLLNMIKGY
What is the function of this protein?
Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.
What are the official names of this protein?
Glucose-1-phosphate thymidylyltransferase, dTDP-glucose pyrophosphorylase, dTDP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the glucose-1-phosphate thymidylyltransferase family.
Protein: NGB_DISMA
Sequence: MEKLSEKDKELIRGSWESLGKNKVPHGVVMFSRLFELDPELLTLFHYTTNCGSTQDCLSSPEFLEHVTKVMLVIDAAVSNLDDLPSLEDFLLNLGRKHQAVGVNTQSFAEVGESLLHMLQCSLGQAYTAPLRQAWLNLYSIVVAAMSQGWAKNGEDKAD
What is the function of this protein?
Involved in oxygen transport in the brain.  Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom.  Capable of penetrating cell membranes (By similarity).
What are the official names of this protein?
Neuroglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
What are the subcellular locations of this protein?
Perikaryon. Cytoplasm. Note=Located in the soma (perikaryon) of most nerve cells in brain. Has ability to penetrate cell membranes and translocate into cells (By similarity).
Protein: ACOT8_HUMAN
Sequence: MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL
What is the function of this protein?
(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).
What are the official names of this protein?
Acyl-coenzyme A thioesterase 8, Acyl-CoA thioesterase 8, Choloyl-coenzyme A thioesterase, HIV-Nef-associated acyl-CoA thioesterase, Peroxisomal acyl-CoA thioesterase 2, PTE-2, Peroxisomal acyl-coenzyme A thioester hydrolase 1, PTE-1, Peroxisomal long-chain acyl-CoA thioesterase 1, Thioesterase II, hACTE-III, hACTEIII, hTE.
What is the protein family that this protein belongs to?
Belongs to the C/M/P thioester hydrolase family.
Protein: ASI1_ARATH
Sequence: MEESVASEGLEFKWGKKKGVGGKKKDVQFYESFTYDGDEYRLYDCVLVGNASEPDSTEPFIGMIIKIWEHANKHIPKKVKLLWFFKPSEIAPYLEGVPNVLANEVFLASGEGLGLANTNQLEAIGGKCSVLCISKDKRNPQPSDEKFNSADFVFCRAFDVGSCKVVDTIDDKIAGVDVKFIFNRACSEKEATAVQNIEADVNGKSDSLKPNGPLARGASGSVRKIEDSAFESSDCKENSNGCKEEKEKGHYQLAIKKSTLAEERSNKDSGSRGNHYNGKDQESEVKKQLTKQKSMPGEERYSNSFEASGSRTIHSISKKAQENDVKKQLTKQKSMPAGERYSQESSGLDDRPLKKQKLDGSVTVRDGWDTTILQNITSDGKKDTGSFKRPRDKVTIEEVPPEKRSFVKNRDLVVSVSEGKTTKTVTEKGISKKPSFGRAEDKMSADDNERNYQVTEVCRRPDAGKSKWFRSLPWEESMREAEKKGTVVLLQNLDPTYTSDEVEDIVYSALNQQCEARMIERTSVTIPHIGEALVIFKTREVAERVIRRLDEGCLLLSSGRPLVASFAKITPPGKPSLFSGHIKLHKTQTRREMRDAVATSHSSQPNNLEFDMAMEWCLHQARHEQASESVSKRQLEEMKSLRINFKLKLP
What is the function of this protein?
Required to prevent promoter DNA hypermethylation and transcriptional silencing of some transgenes (PubMed:24003136).  Plays a similar role to that of the histone H3K9 demethylase JMJ25/IBM1 in preventing CHG methylation in the bodies of numerous genes.  RNA-binding protein that ensures the proper expression of JMJ25/IBM1 full-length transcript by associating with an intronic heterochromatic repeat element of JMJ25/IBM1 (PubMed:24003136, PubMed:23934508, PubMed:24404182).  May associate with intronic heterochromatin and bind gene transcripts to promote their 3' distal polyadenylation (PubMed:24003136).  Contributes to a unique mechanism to deal with the collateral effect of silencing intronic repeat elements (PubMed:24003136, PubMed:23934508, PubMed:24404182).
What are the official names of this protein?
Protein ANTI-SILENCING 1, Protein INCREASE IN BONSAI METHYLATION 2, Protein SHOOT GROWTH 1.
Protein: AAS_ECOLU
Sequence: MLFSFFRNLCRVLYRVRVTGDTQALKGERVLITPNHVSFIDGILLALFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLDPTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQITLHILPPTQVEMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTKTLFVGRILEKYSIEGERIGLMLPNAGISAAVIFGAIARRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFSHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKVHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEAEQHDE
What is the function of this protein?
Plays a role in lysophospholipid acylation.  Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium.  Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
What are the official names of this protein?
Bifunctional protein Aas.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: URED_ECO57
Sequence: MLSTALPQNKKGWQAMLDLRFQRLHGKTTLTTRHHVGLLTVQRPFYPEEETCHLCLLHPPGGIVGGDELIINAIIDSDCHTLITMPGASKFYRSSGAQAHLQQNLTLCNNATLEWLPQDSIFFPGAHATLHTVFHLSSSSTLLAWDLLCLGRPVIGETFSHGTLANRLEIWVDGSPLLIERLHVANGELTCVARKPWVGTMLFYLGNETQLEDIREKLTPLENYAGATLTDGLLTVRFLSDDNLRCQ
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Putative urease accessory protein UreD homolog.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_STRT2
Sequence: MAKSKKIVFTGGGTVGHVTLNLILIPKFLKDGWEVHYIGDKHGVEHEQIDKSGLDVTFHSIATGKLRRYFSWQNMLDVFKVGWGILQSIAIIAKIRPQALFSKGGFVSVPPVIASKLLRVPVYVHESDLSMGLANKIAYKFATTMFTTFEQSKTLVKTRHVGAITKVGMTRFDNSDQLDKIKEQFDEKLKTVLFIGGSAGAKVFNDFISKTPELIENYNIINISGDSSLNTLERHLYRVDYVTDLYQPLMDMADLVVTRGGSNTIFELLAMKKLHLIVPLGKEASRGDQLENADYFERKGYARQLQEPELSWETLKHELEQLVEHAETYKEAMAKSEEITSPDDFYNLLVTSISNK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TSSC4_BOVIN
Sequence: MAEAGHSQHFLDPEVDALPPDTVSLSDSDSDLSLPDGVGVDALSPGGLPGEASGDSGPDEPPSPPRGLPTEAVQPFHLRGTSSTFSQRSHSIFDGLEGAARRAVPAVTPASPGDGGGFQQLLTPSSQPAAGVPGRAAGSPAAQRAPPVPDYVTHPERWTRYSLDDVAEASEQSNRAAALAFLGPQNLAAPGNYMPSFNQDPSSCGEGRLVFTKPTRASEARPDRKRVSRKVGEPGRGDPGVPGAAGGEGPVELAHLARPGSPEAEEWSGPRGGLQEVGASAGVAHARPGSSPPLVETVGFHGSKKRSRDHFRSRGGSPEAPGAEL
What are the official names of this protein?
Protein TSSC4.
What is the protein family that this protein belongs to?
Belongs to the TSSC4 family.
Protein: SSRP_VIBCM
Sequence: MTKKKTNTKAGSNTIALNKKARHEYFIEDEFEAGMELQGWEVKSLRQGKANIAESYVYIKDGEAFISGMTIIPLQQASTHVVANPTRIRKLLLSRRELDNLFGRINREGMTLTALSLYWSRSWVKIKIGVAKGKKLHDKREDLKEKEWQRQKDRVMKSALR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ISPE_BRADU
Sequence: MSPMPALIEEGRAKVNLSLRVVGRRADGYHDLESVVAFADCADRLTLEPGGELKLATTGPLAAACGDTADNLVFKAAKLLAEAVPNLKLGAFALDKVLPVAAGIGGGSADAAAALRLLARLNNLSLDDPRLQKVALATGADVPVCLYSRACDMTGVGEQLLPLALPSMPCVMVNPRVPVATKDVFQALGLRNGELLVGATSVIGAPAWPEEGASIADWVEVLETVANDLEAPAMRIEPVIGEVLEALRDSAGVKLARMSGSGATCFAIYGAPAEAHAAAEKIRRDHPGWWVHAGTLS
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RLMKL_SHIFL
Sequence: MNSLFASTARGLEELLKTELENLGAVECQVVQGGVHFKGDTRLVYQSLMWSRLASRIMLPLGECKVYSDLDLYLGVQAINWTEMFNPGATFAVHFSGLNDTIRNSQYGAMKVKDAIVDAFTRKNLPRPNVDRDAPDIRVNVWLHKETASIALDLSGDGLHLRGYRDRAGIAPIKETLAAAIVMRSGWQSGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGRWGFSGWAQHDEAIWQEVKAEAQTRARKGLAEYSSHFYGSDSDARVIQRARTNARLAGIGELITFEVKDVAQLTNPLPKGPYGTVLSNPPYGERLDSEPALIALHSLLGRIMKNQFGGWNLSLFSASPDLLSCLQLRADKQYKAKNGPLDCVQKNYHVAESTPDSKPAMVAEDYANRLRKNLKKFEKWARQEGIECYRLYDADLPEYNVAVDRYADWVVVQEYAPPKTIDAHKARQRLFDIIAATISVLGIAPNKLVLKTRERHKGKNQYQKLGEKGEFLEVTEYNAHLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSATVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLTRRAHRLIQADCLAWLREANEQFDLIFIDPPTFSNSKRMEDAFDVQRDHLALMKDLKRLLRAGGTIMFSNNKRGFRMDLDGLAKLGLKAQEITQKTLSQDFARNRQIHNCWLITAA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_GEOSW
Sequence: MNIAIIGATGYGGVELLRFLQHHPHVHHCSLYSSSQDGIHFSESFPHVGEIEGAILQKIDVEQMADECEVVFFATPPGVSSTLAPTLIDKGVKVIDLSGDFRLKDRSVYEMWYKRQTASDHYLQQAVYGLTEWNKEDIQKAQLLSNPGCYPTAALLGLAPLVKERLIEEDSIIVDAKSGVSGAGRKASLNTHFSEVNENVKIYKVNSHQHIPEIEQMLKAWNERIQPITFSTHLIPMTRGIMATIYAKAKKELSLETLLDLYKTSYEDSKFVRVRKPGQFPATKEVYGSNYCDIGVAYDERTGRVTVVSVIDNLVKGAAGQAIQNLNVMMGWDEESGLMLAPIYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y556_BUCAI
Sequence: MSDTKKSFKNVLEFVHKFRRKNKIKREISDIEKKIRDNQKRILLLDNLIQYITLDMNYEEIKKIIFMMKSDYEDRIDDYIVKNAELSKEKRNLSKELKFIIK
What are the official names of this protein?
UPF0265 protein BU556.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: SAMD9_HUMAN
Sequence: MAKQLNLPENTDDWTKEDVNQWLESHKIDQKHREILTEQDVNGAVLKWLKKEHLVDMGITHGPAIQIEELFKELRKTAIEDSIQTSKMGKPSKNAPKDQTVSQKERRETSKQKQKGKENPDMANPSAMSTTAKGSKSLKVELIEDKIDYTKERQPSIDLTCVSYPFDEFSNPYRYKLDFSLQPETGPGNLIDPIHEFKAFTNTATATEEDVKMKFSNEVFRFASACMNSRTNGTIHFGVKDKPHGKIVGIKVTNDTKEALINHFNLMINKYFEDHQVQQAKKCIREPRFVEVLLPNSTLSDRFVIEVDIIPQFSECQYDYFQIKMQNYNNKIWEQSKKFSLFVRDGTSSKDITKNKVDFRAFKADFKTLAESRKAAEEKFRAKTNKKEREGPKLVKLLTGNQDLLDNSYYEQYILVTNKCHPDQTKHLDFLKEIKWFAVLEFDPESNINGVVKAYKESRVANLHFPSVYVEQKTTPNETISTLNLYHQPSWIFCNGRLDLDSEKYKPFDPSSWQRERASDVRKLISFLTHEDIMPRGKFLVVFLLLSSVDDPRDPLIETFCAFYQDLKGMENILCICVHPHIFQGWKDLLEARLIKHQDEISSQCISALSLEEINGTILKLKSVTQSSKRLLPSIGLSTVLLKKEEDIMTALEIICENECEGTLLEKDKNKFLEFKASKEEDFYRGGKVSWWNFYFSSESYSSPFVKRDKYERLEAMIQNCADSSKPTSTKIIHLYHHPGCGGTTLAMHILWELRKKFRCAVLKNKTVDFSEIGEQVTSLITYGAMNRQEYVPVLLLVDDFEEQDNVYLLQYSIQTAIAKKYIRYEKPLVIILNCMRSQNPEKSARIPDSIAVIQQLSPKEQRAFELKLKEIKEQHKNFEDFYSFMIMKTNFNKEYIENVVRNILKGQNIFTKEAKLFSFLALLNSYVPDTTISLSQCEKFLGIGNKKAFWGTEKFEDKMGTYSTILIKTEVIECGNYCGVRIIHSLIAEFSLEELKKSYHLNKSQIMLDMLTENLFFDTGMGKSKFLQDMHTLLLTRHRDEHEGETGNWFSPFIEALHKDEGNEAVEAVLLESIHRFNPNAFICQALARHFYIKKKDFGNALNWAKQAKIIEPDNSYISDTLGQVYKSKIRWWIEENGGNGNISVDDLIALLDLAEHASSAFKESQQQSEDREYEVKERLYPKSKRRYDTYNIAGYQGEIEVGLYTIQILQLIPFFDNKNELSKRYMVNFVSGSSDIPGDPNNEYKLALKNYIPYLTKLKFSLKKSFDFFDEYFVLLKPRNNIKQNEEAKTRRKVAGYFKKYVDIFCLLEESQNNTGLGSKFSEPLQVERCRRNLVALKADKFSGLLEYLIKSQEDAISTMKCIVNEYTFLLEQCTVKIQSKEKLNFILANIILSCIQPTSRLVKPVEKLKDQLREVLQPIGLTYQFSEPYFLASLLFWPENQQLDQHSEQMKEYAQALKNSFKGQYKHMHRTKQPIAYFFLGKGKRLERLVHKGKIDQCFKKTPDINSLWQSGDVWKEEKVQELLLRLQGRAENNCLYIEYGINEKITIPITPAFLGQLRSGRSIEKVSFYLGFSIGGPLAYDIEIV
What is the function of this protein?
Double-stranded nucleic acid binding that acts as a an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules (PubMed:25428864, PubMed:28157624).  May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling.  Involved in the regulation of EGR1, in coordination with RGL2.  May be involved in endosome fusion.
What are the official names of this protein?
Sterile alpha motif domain-containing protein 9, SAM domain-containing protein 9.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUAA_DROME
Sequence: MTAVFRVGLVRLVSRATQSPNLLQAQTNALPAAFQQRCSISGKTMRGGPRVPKAAPYPYKTKKYSVFNAIFDKTSKRFDENSKVICVEGPIAAGKSKFAKELAEELDMEYYPAVDLDLIYINSYGYDMRKLDPQLPPSCRSYDVRNFCLDPSHDLAAQFQIRMYMLRYSQYIDALQHVLSTGQGVVLERSPYSDFVFMEAMFRQGYLSRGARSVYNELRQNTIGELLKPHLVIYLDLPVDAVKKQIKARNVDYEVQSKVFSDAYLSDLEQLYKQQYLKDISTHAELLIYDWTAGGETEVVVEDIERIDFNQFEADIHNKKMLDWRFPLEAEWCEARIKYCHEKPDLMNYFNVPRFDVPELVRSADDGKVWRDVWFNAPGMKYRPGYNADMGDEGLLTKTKIGINQGI
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial, Complex I-42kD, CI-42kD, NADH-ubiquinone oxidoreductase 42 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA10 subunit family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Cytoplasm.
Protein: UB2WB_DANRE
Sequence: MASMQKRLQKELLALQNDPPPGMTLNEKSVQNTITQWIVDMEGASGTVYEGEKFQLLFKFSSRYPFDSPQVMFTGDNIPVHPHVYSNGHICLSILTEDWSPALSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  Catalyzes monoubiquitination.  Involved in degradation of misfolded chaperone substrate and DNA repair.
What are the official names of this protein?
Probable ubiquitin-conjugating enzyme E2 W-B, E2 ubiquitin-conjugating enzyme W-B, N-terminal E2 ubiquitin-conjugating enzyme, Ubiquitin carrier protein W-B, Ubiquitin-protein ligase W-B.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACPS_THET8
Sequence: MIVALGADLVEIARVERLLSRHGERALRRLFHEEEVAYALARQNPFPSLAARLAAKEAFQKCWPESLSWKEVWVGMEGKRPALRFAPRIEARMAEEGLFAHLSLSHERSHALAVVVLEARARGGG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: V034_FOWPN
Sequence: MKTKMFGLHEPICIKLLEQAIELKDYIVVRMILNQQENINTYKHFNMLRKAVLNHDHNLVNIFIDKNFNINIADSVGYTLLRYAVEVDDVNIAKILLDAGSIINKNDYRLLHSAITHENKKMIELLCLHGININVKDDKGYTALYYTICNNNYDMVCFLLEKNADISIVNKYSMLHFLSTSNKYHNVMAVLLDKGIDVNIINHVKAPIHVAVERNNIYGTMLLINRNADVNIKELHGGRTSLHLAIKERNYEAAFVLINNGANVDSFDDVGNTPIFIAASLQDVRFMKLLLDNGADINVRNVFGETPVNMVITGGSKEVTQYTVSYLISLKVDNIVLNDFCAYKQNMNLIHRINYGSPRLFMEYIGDIYEWHLPYSVLTDDKPINYSKIQSKVSHNESRFLPYKKRYNYNNTLIQ
What are the official names of this protein?
Putative ankyrin repeat protein FPV034.
Protein: SFAS_DUNBI
Sequence: MATSGMVSPTSGRPFSPMRSSVLTTTGSAIKLEHVSEKFAGLWTDLEQEKQARRIAEATRMQLFQESVLRLEKSMEAEVKRRAESDKQLQAHFEGELRVLHERSACQVAEMHNSLKSAIDSFSSRVQDLHAVIREERDQRRNDIEHLATSLVGKVNECVAALDEERTIRMQEQAMALKRFGEDISGVNHRVDTEKAQREADLSGLRVEIHDVLANRNIQDEQFKTVTLDELNAFKAALALEREERVAEDDEIVQAINDYTRALQEGLKMVNMQHNSA
What is the function of this protein?
Major component of the striated microtubule-associated fibers (SMAFs; system-I-fibers).
What are the official names of this protein?
SF-assemblin.
What is the protein family that this protein belongs to?
Belongs to the SF-assemblin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.