PharMolix/UniProtQA huggingface dataset:
Protein: SRBS2_PIG
Sequence: MRAATPLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVTKPQAGRRKV
What is the function of this protein?
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton.  Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity).  May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12.  Increases water and sodium absorption in the intestine and gall-bladder.
What are the official names of this protein?
Sorbin and SH3 domain-containing protein 2, Arg-binding protein 2, ArgBP2.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium. Note=Detected in the stress fibers, synaptosomal cytosol, postsynaptic density fraction, Z-disks and intercalated. The CBL/PTK2B/ARGBP2 complex is recruited to lipid rafts following growth factor stimulation. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells.
Protein: SRE1_CAEEL
Sequence: MNLQYSPVFKCPPEMVTHCQWIYWFTHFELLAMIIEIPSFLLVIYATIKSPFHYNLNFIGLFMLLGYYVFLVGRFITCLYEIGSLTVKDEDAENEIYPMPLILSSILQFFYMGCACGISLAVAFERFFATYFVETYEKKKRKWISLFLCSEFTVACGVSAIVMLYDLLPFAVMAFLGVFISCASFLFYLVLFYMNKRRLHTIQQDRDNDVYTLSVRFQLSENLKVMTLLRNVVLFSGVNNFVMAIILTMYMSKSFKVSYPLATLYLHFAFNCCVLLYSFLMLIIIIFSVKQYRMYYFSIRFVRVVLYPLVGRCFQNEFSQSPVQQLTIRDETESYFVNLSSQWDEKFQKINRLSI
What are the official names of this protein?
Serpentine receptor class epsilon-1, Protein sre-1.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein sre family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATPF_DEHM1
Sequence: MEKLAELGINIPSFIAQVVNFGLLLGLLYLFAYKPILAKLDERSARIKESMERTDQVKEQAQRAEEEFKKKIGEASQQGQLVIERAVKTGDEIRQKAIEEARAEAEAMLSRARTEIRQERDEVVDQLRKEFAELTILAAGKVIDQSLDKKAHQALIDSVLENSTNLRKN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: FTR_ARCFU
Sequence: MKVNGVEVEETFAEAFDIKIARVLITGYDYYWAWVAANEATGFGTSVIMCPAEAGIEIKAKPSETPDGRPGYYIQICHMSKKGLEEQLLARLGQCVLTAPTTAVFNGLPDAEEKFDTGFKLKFFADGYEKEVEVGGRKCWAVPMMEGDFIIENDIGYTNGIAGGNFFIMAETQPSALAAAKAAVDAISDVEGVITPFPGGIVASGSKVGANKYKFLKASTNEKFAPSIRDQVEGTQIPEGVKAVYEIVINGLNADAIKEATRVGILAATKIPGVVKITAGNYGGKLGKHIINLNELF
What is the function of this protein?
Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
What are the official names of this protein?
Formylmethanofuran--tetrahydromethanopterin formyltransferase, Ftr, H4MPT formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the FTR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SKU5_ARATH
Sequence: MDLFKILLLVFFVNISFCFAADPYSFYNFEVSYITASPLGVPQQVIAINGKFPGPTINVTTNENLVVNVRNKLDEGLLLHWNGIQQRRVSWQDGVLGTNCPIPPKWNWTYEFQVKDQIGSFFYFPSLHFQRASGGFGSFVVNPRAIIPVPFSTPDGDITVTIGDWYIRNHTALRKALDDGKDLGMPDGVLINGKGPYRYNDTLVADGIDFETITVHPGKTYRLRVSNVGISTSLNFRIQGHNLVLAESEGSYTVQQNYTSLDIHVGQSYSFLVTMDQNASSDYYIVASARVVNETIWRRVTGVGILKYTNSKGKAKGQLPPGPQDEFDKTFSMNQARSIRWNVSASGARPNPQGSFKYGSINVTDVYVLRNMPPVTISGKRRTTLNGISFKNPSTPIRLADKLKVKDVYKLDFPKRPLTGPAKVATSIINGTYRGFMEVVLQNNDTKMQSYHMSGYAFFVVGMDYGEWTENSRGTYNKWDGIARSTIQVYPGAWSAILISLDNPGAWNLRTENLDSWYLGQETYVRVVNPDENNKTEFGHPDNVLYCGALSKLQKPQKVSSSASKSIGFTSLSMVVMALVMMMMLQH
What is the function of this protein?
May be a monocopper oxidase of unknown specificity.  Involved in directional growth processes, possibly by participating in cell wall expansion.
What are the official names of this protein?
Monocopper oxidase-like protein SKU5, Skewed roots.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell membrane; Lipid- anchor, GPI-anchor; Extracellular side. Note=Partially soluble and located in the cell wall.
Protein: AGO7_ORYSJ
Sequence: MEGEREGVVAKNEDNAGGGGGGLGTGGNGGGGGGGSANGRRRWRGGGSSGYRQHPIIQAYPALLPLPINGATGHAHINGAVSLPLPLPPPVLLYLQPPPPPPLLPLLPKVAAATFYGKPPKAADAAPRGSMWKHRPSKKPPPHAITAALLPLPRDGKALQEKIFFANERKTSEKEVNHVDTHEKFTVAPLDNAIARRPDMGGVEGAEIPLSANHFLVQFDPGQKIFHYNVDISPRPSKETARMIKKKLVEENPSVLSGSQPAFDGRKNLYSPVRFQEDRVEFFVSLPVALARCSVVKEDTGHMLDKQKLKTFKVNVRLVSKLCGEDLNKYLNEDKDGIPLPQDYLHALDVVLREGAMESSILVGRSLYARSMGEARDIGGGAVGLRGFFQRLRPTKQGLALNVDLSLSAFHESTGIISYLQKRCDFLKDLPQKKTRALAEEEHREVEKALKNIRVFVCHRETNQRYHVHSLTKETTENLKFRDRSGKDLMVVDYFKEHYNHDIQFRNLPCLQIGRSKPCYVPMELCVVCEGQKFLGKLSDEQTSKILKMGCERPSERKGIIKGVVKGAFHARSDTYADQFSLQVSKHMTKLSGRVLLPPKLKLGSSGRIKDITPDRFDRQWSFLDSHVAEGSKIKSWALISFGGTPEQHFCITKFVNQLSNRCEQLGILLNKKTIISPIFERIQLLNNVGILEGKLKKIQEAASGNLQLLICVMERRHQGYADLKRIAETSIGVVTQCCLYSNLSKLTSQFLTNLALKINAKLGGCNIALYSSFPCQIPRIFLSEEPVMFMGADVTHPHPLDDSSPSVVAVVASMNWPSANKYISRMRSQTHRKEIIEQLDVMAGELLEEFLKEVGKLPSRIIFFRDGVSETQFYKVLKEEMHAVRTTCSRYPGYKPLITFIVVQKRHHTRLFHRERNGSSSHYSDQNIPPGTVVDTVITHPREFDFYLCSHWGTKGTSRPTHYHVLWDENNFRSDEVQQLIHNLCYTFARCTRPVSLVPPAYYAHLAAYRGRLYLERSDTTMYRVSPLQTVPLPKLRDNVKRLMFYC
What is the function of this protein?
Involved in the RNA silencing pathway.  May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity).  Regulates shoot apical meristem (SAM) initiation and maintenance and leaf polarization through the trans-acting siRNAS (ta-siRNAs) pathway which probably modulates the expression of the ARF2, ARF3, ARF4, ARF14 and ARF15 genes.
What are the official names of this protein?
Protein argonaute 7, OsAGO7, Protein SHOOT ORGANIZATION 2, Protein SHOOTLESS 4.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Ago subfamily.
Protein: CLHC1_MOUSE
Sequence: MSVQEVNTHAVLPPIVSRNDKEFLESIQRYITTETKRVGCKEEGPADEYYTIYRNVFDKFSATDRKIIFQVIDYVSAYKSILTAIKKEYDAFIETIKKGRRTAFYLHGKLKVLAKEPTALVYHQRRAIQLEAKMRIIENNSTAIQLQIDQMKQLRMEYDKKEVKLCAPSRQLWKPIPGMTLQDSVNLEALNKHKQYLEDKYIKLKQDMSTMYVPAQKKAELDEEMVVLLNRRDIAENLKKDRQFRHQRLQVISHTLTPWMKQNMRISFQDVMERIRKTKAIYGYDNIVDEIFEDDPNKKKEAIVMLHYIERFNDLISLGEYERAACFAANSPKRILQNTSTMNKFKAIGKIRGKPLPLLLFFEAIFNTSQAFKRPINADLTMEGIKCGLSEERLDLVTHWVTQEKLTFSEKAGDIIFAYGEQHTYHKPRCLALAQIIYNECGLHRKALLCLCKQGQIHEAMEHIQQSKDINTDDLIQLITACPQIDLIRCLTQERNEKPPFLSFGLAVLHMFSVDMKKVGMRLLQEVSKGEKDVIEHLVMSDLFCSLEKWQEIANICLQNGFKILFNDIMSILRSQAGVSEISEDDTTNIMEHVFW
What are the official names of this protein?
Clathrin heavy chain linker domain-containing protein 1.
Protein: ATPF_MYCCT
Sequence: MLSVGFNIAINATTQGVPKIIESLFPNLPNFIAHLLATIVLVIVLAKLVYKPYKQMIEKQRQKITEVLSDAIEKQTQANIKIKQANSLLEEAKTESVSIINTARVDAEIQKNKIIDNANLQAKNIQSYAQNSIKQEKIKAQLEIKNTIVNLAINSAEKILSKEIDKNTNKKLIEEFIKDLD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: TF2H5_BOVIN
Sequence: MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGELMDQNAFSLTQK
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.  Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
What are the official names of this protein?
General transcription factor IIH subunit 5, General transcription factor IIH polypeptide 5, TFB5 ortholog, TFIIH basal transcription factor complex TTD-A subunit, TFIIH subunit p8.
What is the protein family that this protein belongs to?
Belongs to the TFB5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: NUOC_MYCVP
Sequence: MTGDDEPDPEVIGVRRGMFGAKGSGDTSGYGRLIRSVALPGSSPRPYGGYFDDVVDALESALGHDVFAESVERVVVYRDELTLEVHRDRLVDVAQTLRDDPDLRFELCLGVSGVHYPDDADRELHAVYPLMSITHNRRIRIEVAAPDSDPHIPSLFRVYPTTDWHERETYDFFGLIFDGHPALTRIEMPDDWVGHPQRKDYPLGGIPVEYHGAEIPPPDERRAYS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MSHR_LEOFU
Sequence: MPMQGAHRKLLGSLNSTPTATSNLGLAANHTGAPCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSSMYCFICCLALSDLLVSGSNMLETAVILLLEAGALATRTSVVQQLHNTIDVLTCSSMLCSLCFLGAIAVDRYISIFYALRYHSIMTLPRAQRAIAAIWVASVLSSTLFITYYDHAAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAHGIIRLHKRQSPAHQGFGLRGAATLTILLGIFFLCWGPFFLHLTLVVFCPQHLTCSCIFKNFKVFLTLIICNTIIDPLIYAFRSQELRRTLKEVLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SLMA_ECO8A
Sequence: MAEKQTAKRNRREEILQSLALMLESSDGSQRITTAKLAASVGVSEAALYRHFPSKTRMFDSLIEFIEDSLITRINLILKDEKDTTARLRLIVLLLLGFGERNPGLTRILTGHALMFEQDRLQGRINQLFERIEAQLRQVLREKRMREGEGYTTDETLLASQILAFCEGMLSRFVRSEFKYRPTDDFDARWPLIAAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RL14_MARN8
Sequence: MIQTQTMLEVADNSGARQVMCIKVLGGSHRRYATVGDIIKVTVKEAIPRGKVKKGQVLKAVVVRTRKGVRRPDGSLIRFDGNAAVLLNNQDAPIGTRIFGPVTRELRNEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PRMC_MOOTA
Sequence: MTLRQALGEAVRRLAAGGVERPRLEAEVLLGWACSLTRPRLLARLEEELAPAAAGRFWQAIDRRAAGYPLQYLTGHQEFMSLDFKVTPAVLIPRQDTEVVVEAVLERLDPCESYTIADCGTGSGAIALSLAHYLPRARVYATDISPAALTVAQENARKLGLAARVTLLQGDFLAPLRGLKLDALVANPPYIPTAALPGLPADVRSEPRLALDGGPDGLDAYRFLLPGAAGLLRPGGLLALEIGSDQGQAVKDLARAVGAYRNEQVLPDYAGRDRCFLAYRREE
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: HUTU_BRADU
Sequence: MNRRLDNDRTIRAPRGRDISAKSWLTEAPLRMLMNNLDPDVAERPSELVVYGGIGRAARDWESFDRITAALRKLEDDETLLIQSGKPVGVFRTHADAPRVLIANSNIVPHWATLDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEVGRRHYGGSLAGKWILTAGLGGMGGAQPLAATMAGASMLAVECQPSRIEMRLRTGYLDRQAATLDEALAIMEESAKTKKAISVGLLGNAAEIFPELVRRGVKPDIVTDQTSAHDPINGYLPKGWTLADWEAKRASDPKAVERASKTSMVEHVQAMLDFHAQGIPTLDYGNNIRQMAQDMGLKNAFDFPGFVPAYIRPLFCRGVGPFRWAALSGDPEDIFKTDAKVKELMPDDKHLHNWLDMARERIKFQGLPARICWVGLGDRHRLGLAFNEMVARGELKAPVVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNCASGATWVSLHHGGGVGIGYSQHAGMVIVADGTPEAAKRIARVLWNDPATGVMRHADAGYDIAIDCARDKGLDLPSLSK
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_PSEA8
Sequence: MAKQKKHPSGTIAQNKKALHDYFIEQRFEAGVALAGWEVKSLRAGKAQLVDSYVLLKDGEAWLLGSHITPLTTASTHVIADPVRTRKLLLHKRELGKLFGAVQQKGYACVALSMYWKKHLVKCEIALAKGKKDFDKRHTEKERDSDREIQRAMRHGKDD
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: P2C54_ORYSJ
Sequence: MCVEESEGAERLDFGEPAAAAADAGKSKSKSPDELPSPRMERVCENTTAADFKQNKSGNFVPNIRSGDWSDIGGRQYMEDTHVCITDLAKNFGYQSVDNEAISFYGVFDGHGGKDAAHFVRDNLPRIIVEDADFPLELEKVVRRSFVHADNQFAKTTLSSGTTALTAMIFGRTLLIANAGDCRAVLSRCGTAIEMSVDHRPCSLSEKLRVESLGGYVDDGYLNGLLGVTRALGDWHLEGMKEAGNPGGPLSAEPELKMITLTKDDEFLIIGSDGIWDVFSNQNVVDFARRRLQEHNDVKSCCREIVEEAIKRGATDNLTAVLVSFHLEAPPQVRVSRPGRVARSISAEGLNSLRTLLRNQ
What are the official names of this protein?
Probable protein phosphatase 2C 54, OsPP2C54.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: Y503_DESOH
Sequence: MRNFIIHILTGLSGSGKSTALDVFEDAGFYCVDNMPVALLPKFLEIPVNTASGISGLAFVMDLREPDFLATYPSVFNDLKAQGYRLTVLFFEAGENVLIQRYSQTRRHHPLAGDKGLVSGIRRERELLEELRASSDTVIDTSTLTIHELKIRLLARIRKSADHMPMRIHVMSFGYKYGIPHDADIIMDVRFLPNPYFVDPLKHKNGTDADVAAHVLNHSTGSAFLEKFLNLIDFLLPLYKNEPKAYLTVAVGCTGGCHRSVAVATAVFNHMKKREERHVEISHRDLKEAGQTT
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Dole_0503.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ADA_PLACD
Sequence: MNILQEPIDFLKKDEIKNIDLSQMSKKERYKIWKRIPKCELHCHLDLCFSADFFLSCIRKYNLQPNLSDEEVLDYYLFAKGGKSLGEFVEKAIRVADIFHDYEVIEDLAKHAVFNKYKEGVVLMEFRYSPTFVAFKYKLDIELIHQAIVKGIKEVVELLDHKIHVALMCIGDTGHEAANIKASADFCLKHRADFVGFDHGGHEVDLKQYKEIFDYVRESGIPLSVHAGEDVTLPNLNTLYSAIQVLKVERIGHGIRVSESQELIDMVKEKNILLEVCPISNVLLKNAKSMDTHPIRQLYDAGVKVSVNSDDPGMFLTNINDDYEELYTHLNFTLEDFMKMNEWALEKSFMDSNIKDKVKNLYF
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine to produce inosine (PubMed:19728741).  Unlike mammalian adenosine deaminases, also catalyzes the deamination of 5'-methylthioadenosine (MTA), a by-product of polyamine biosynthesis, to produce 5'-methylthioinosine (MTI) (PubMed:19728741).  Plays an essential role in the purine salvage pathway which allows the parasite to use host cell purines for the synthesis of nucleic acids (Probable).
What are the official names of this protein?
Adenosine deaminase, S-methyl-5'-thioadenosine deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Protein: YBZ4_YEAST
Sequence: MLFDSSFRERRTFYNAAGSVSVPFYKQIAEQTHDIFKRCNVREHILRPCPVDISHFSRDLNGAPLSYTENIKFTAKFWANAWIDYESVMKTLLVKLYISFFFMC
What are the official names of this protein?
Uncharacterized protein YBR144C.
Protein: IZUM4_MACFA
Sequence: MALLLCLVGVTAALAHGCLHCHSKFSEKFSFYRHHVNLKSWWVGDIPVSGALLTDWSDDTMKELHLAIPAEITREKLDQVATAVYQRMDQLYQGKMYFPGYFPNELRNIFREQVHLIQNAIIESRLDCQRHCGIFQYETISCNNCTDSHVACFGYNCESSEQWESAVQGLLNYINNWHKQDVSMRATPAFLVSPAFRCLEPPHLANLTLEDAAECLKQH
What are the official names of this protein?
Izumo sperm-egg fusion protein 4.
What is the protein family that this protein belongs to?
Belongs to the Izumo family.
What are the subcellular locations of this protein?
Secreted.
Protein: MS116_KLULA
Sequence: MLVLQRIPKRALQFNGVTGTVCSTRLFHHAFNLNLQQSFVPSEERRYRNSNRGFTRGSDSNSNNKYRNSSYDDNRSRSNYGGDKRNNRNNNNYGNNRNNGSRRRYQDENSDIEVFKSKSFNVTTLNPESFHEQVTIDSLLEESLLDANVHKAISAMKFESLTPVQQRTIKPILTTENDVVAKAKTGTGKTLAFLAPLFQHLISTKLQNPLAVKAVIVTPTRDLAIQIASEVKKLQQCNPSLKSYRSLTLIGGTNLDKSLKDLHTLNPNIIVGTPGRINDILDRVGAKYFKDVDFKVLDEADTLLQIGFQTELSLISRKLNEFNTQGEEHIRTLLFSATMDHNVQELAATIMNKKDCLFIDTVDKNDSEAHDSIDQKLVITKSFAESMVALIQSIESELLQKKNFKAILFLPTVKFVDFFSETLSESLTKRIDIIKFHGKIDQKKRTKLVDRFKKTNHGIFVCTDVGARGMHFPSVEHVYQLCVPTSLPNYIHRIGRTARAGESGAATIFLFREELKFVDELRRDTNVVIKNQEDYLNQDKENFDMISSIITNNPDFPEALKSIIGFYKGVQNEYRLNYKVAQNVLRSFSELHSDSSMLLRFRPSEINNFFSNRDMRFVSDLIDVKNPHSFGKDREFDDEDRYTSRSQNNYKSKQSSKSNRFEGRNDYSNSRRSHANQKRNFTFDD
What is the function of this protein?
ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns.  Also required for efficient mitochondrial translation (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase MSS116, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NEF_HV1OY
Sequence: MGGKWSKCSMKGWPTIRERMKRAELQPPEPAAEGVGAASRDLEKHGAITSSNTAATNADCAWLEAQEDEEVGFPVRPQVPLRPMTYKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPDWQNYTPGPGIRYPLCFGWCFKLVPMDPDQVEEANEGENNSLLHPISLHGMDDPEKEVLVWKFDSRLAFRHMAREVHPEYYKDC
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane. Note=TGN localization requires PACS1. Associates with the inner plasma membrane through its N-terminal domain. Nef stimulates its own export via the release of exosomes. Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved.
Protein: ASSY_PROM5
Sequence: MQHPKKVVLAYSGGVDTSVCIPYLKNEYGISEVITFVADLGQGDDIESISQKALNSGATKSVIGNLVEDFVEKYAFPAIRANALYGEKYPLSTALARPLIAENLVKLARKLNAGAVAHGCTGKGNDQVRFDLAINALGPDLEIITPAREWKMSREEAILYGEKFGIPAPVSKKSPYSIDVNLLGRSVEAGFLEDPMQEPNEEVFAMTSSIDDSPNYPKDIEITFKNGFPIAIGNESLSPLKIIQKVNYLAGKNGFGRIDMIEDRVVGIKSREIYEAPGLLLLIKAHKELESITLNPDVLDFKNLVEKKWAQLVYQGFWFGPLKKALDGFIDATQTSVNGKVKIRLHKGNAIIIGRSSENNSLYREDLATYSKDDIFDHKQAEGFIYMWGMSNKIWAELNSKMNN
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNT_RABIT
Sequence: MAATTANPEMTSDVPSLGPNITSGNPGPAIQGGGTIVQRAVKRRPGLDFDDDGEGNSKFLRCDEDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDIVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNSSVDPVSMNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNREWLWTRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNPIQRPQLGPTANLPLEVGSGQLAPRQQQQQTELDMVPGRDGLTNYNHSQISVQPVATTGPEHGKPLEKSDSLFAQDRDPRFSEMYSNINADQSKGISSSTVPATQQLFSQGNTFPPNPRPAENFRNSGLAPPVTIVQASASAGEMLAQISRHSNPTQGTAPTWTPSTRPGFSAQQVASQATTKSRSSQFGVGNFQSPSSFSSMSLSSTSTASSGAAAYPSLTSRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSTSSEQHVQQPSTQQPNQPEVFQEMLSMLGDQSSSYNNEEFPDLTMFPSFSE
What is the function of this protein?
Required for activity of the AHR.  Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE).  Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding.  The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity).  The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).  The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).
What are the official names of this protein?
Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta.
What are the subcellular locations of this protein?
Nucleus.