PharMolix/UniProtQA huggingface dataset:
Protein: CASP7_MOUSE
Sequence: MTDDQDCAAELEKVDSSSEDGVDAKPDRSSIISSILLKKKRNASAGPVRTGRDRVPTYLYRMDFQKMGKCIIINNKNFDKATGMDVRNGTDKDAGALFKCFQNLGFEVTVHNDCSCAKMQDLLRKASEEDHSNSACFACVLLSHGEEDLIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDIDANPRNKIPVEADFLFAYSTVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFESQSDDPRFNEKKQIPCMVSMLTKELYFSR
What is the function of this protein?
Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:16469926, PubMed:19168786).  Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:25231987).  Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (PubMed:18667412, PubMed:35705808).  Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8 and/or CASP9), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:16469926).  Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:16469926).  Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:35705808).  Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S. typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (PubMed:22807671, PubMed:35705808).  Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (PubMed:35705808).  Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733).  Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284).  Cleaves and activates sterol regulatory element binding proteins (SREBPs) (By similarity).  Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (PubMed:25231987).
What are the official names of this protein?
Caspase-7, CASP-7, Apoptotic protease Mch-3, Cysteine protease LICE2.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_PHOLL
Sequence: MTSHTLTSFGRQISSPVIVALDYDNQDTALAFADKIDPQDCRLKVGKEMFTLHGPQFVKLLHQRGFEVFLDLKFHDIPNTTARAVAAAAEMGVWMVNVHASGGTRMMTAAKEALLPYGHDAPLLIAVTVLTSMEQSDLQGIGIDMTPAQQAERLAKLTQACGLDGVVCSAHEAQQLKKVCGQHFQLVTPGIRPTGSDVGDQRRIMTPEQAVLAGVDYMVIGRPITRAADPAAALRQINQSIAGVINAR
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: PANZ_ECOLI
Sequence: MKLTIIRLEKFSDQDRIDLQKIWPEYSPSSLQVDDNHRIYAARFNERLLAAVRVTLSGTEGALDSLRVREVTRRRGVGQYLLEEVLRNNPGVSCWWMADAGVEDRGVMTAFMQALGFTAQQGGWEKC
What is the function of this protein?
Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion.  Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD (PubMed:23170229, PubMed:25910242).  Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA (PubMed:25910242).
What are the official names of this protein?
PanD regulatory factor.
What is the protein family that this protein belongs to?
Belongs to the PanZ/PanM family.
Protein: MYL6B_MOUSE
Sequence: MPPKKDAPVKKPAGPSISKPAAKSTPGTPLAKAKAEPAAPQAPAKSQEPPVDLSKVVIEFNKDQLEEFREAFELFDRVGDGKILYSQCGDLMRALGQNPTNAEVLKVLGNPKNEELKSRRVDFETFLPMLQAVAKNRDQGTYEDYLEGLRVFDKEGNGKVMGAELRHVLTTLGEKMTEEEVETVLAGHEDSNGCINYEAFLKHILSL
What is the function of this protein?
Regulatory light chain of myosin.  Does not bind calcium.
What are the official names of this protein?
Myosin light chain 6B, Smooth muscle and nonmuscle myosin light chain alkali 6B.
Protein: PFS2_CRYNJ
Sequence: MTAPTVPADQHGHPLPGPADPAANDTWRPSRYREPLHPDNEEVLEQAAYQAAVTRSSGDDRKRKIKPRRTVDYQGGVQKWRMLNKLKGVHEFRPAIHPNPSDIVNFLPPVALRSNPSTSICDYWVHTSINKERSPTRVVRWTPDARRLLTGNDKGQFTLWNGASFNYESITQVHDDSIRSFTYSHNGQALVSADKGGTIKYFTPHLTNIHGFQGHREACHDVSWSPNDERFVTCGDDGLVKIWSYREAKEERSLSGHGWDVRCVDWHPTKGLIVSGSKDMLVKFWDPRTGKDLSTLHSSKSTINTCRWSPDGHLVATAGQDSVIRLFDIRTFRELEVLKGHEKEVNCIEWHPIHHSLLVSGDALGTINYFSLLSPTPSTPITTLSAAHEDAVFSLSFHPLGHILCSGSKDFTARFWCRARPPGGQEFDKWHLTEEGAAQKELERITKREWGTNAPPANAAGGGGGGGGDKQQVALPGLSNLVAAVNSVKTGPTTTGGGPSGLPGLGAPNVHAGTPPSRVSTPSSMGPPGPGAQGQAQGGQFPRGRSALPSQNDMLRHNHGSRGGFADRDRNGGGDRGGMDRDRDSRGGRQDPRGNQMYGRGPGGPPPGPPPGQGGYNYPPAPPNYPPYPPSSYPPPPNNQPGYPPAPNYAMPPGPGAPPQSYPYNRPPQGPPQNNNPGGQGNYGASASGGYGQYGGGGGGGGGGGYGRDGRR
What is the function of this protein?
Required for 3'-end cleavage and polyadenylation of pre-mRNAs.  Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).
What are the official names of this protein?
Polyadenylation factor subunit 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: DEOB_HELPG
Sequence: MQKRVVVLLLDSFGIGASEDAKDFGDFGANTLGNIAKACFNNLANSNDRNGALKLPYLESLGLGLSALKATNELPLGFESKPNLIGAYAYAKELSSAKDTISGHWEMMGAPVLFEWGYFKDKTHSFPKEILDEIMHKTKIKGYLGNCHASGTEIIKDLGEKHLETLYPIFYTSADSVFQIAAHEEKFGLDNLYALCEEVFQILEPLKIARVIARPFIGANREDFKRTAKRKDYAIKPHKKLLFEKFIEEKQGEVISIGKIADIYAHVGITQKFKAGSLMELCDVTLDQVKNAKNNSLIFTNFVHFDSDYGHRRDISGYANALEYFDTRLKEVLENLKENDLLILCADHGCDPSFKGTDHTREYIPVLFYHKDLQPAFLGKSESFADIGQSIAYFLGLSPLDYGKNLLKFKGQP
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_ALKCK
Sequence: MDQERHEFSIDWAGRTLSVEVGQLAKQANGAVLVRYGDTAVLSTATASKEPKDLPFFPLTVNYEERLYAAGKIPGGFIKREGRPSERAILTSRLIDRPIRPLFPDGFRNDVQVISIVMSSDQDASPEMAAMIGSSLALCVSDIPFEGPIAGVTVGRINGEFIMNPTPAQLAESDIDLTVAGTKEAINMVEAGAKEVPEDVMLEAILAGHENIKKMIAFQEKVVEVCGKEKREVQLKTFDAELEARLRESAEASIKEAVRIAEKHARQDAIDEIIAAQVEQHSDDDSINVDEVKEILQMFVKEEVRRLITVEKIRPDGRGVDEIRPLSSQIKLLPRTHGSGLFTRGQTQALSVCTLGALGDVQVLDGLGIEETKRFMHHYNFPQFSVGETGPIRAPGRREIGHGALGERALEQVIPSEQEFPYTIRLVSEVLESNGSTSQASICASTLAMMDAGVPIKAPVAGIAMGLVKQGEHMTVLTDIQGMEDALGDMDFKVAGTANGVTALQMDIKISGINREVLEQALEQAKQGRMKILSNMMEAIDKPRAELSEYAPKILTLTINPDKIRDVIGPSGKVINKIIEETGVKIDIEQDGTVYISSLDTAMNQKAKQIIEDLVREVQVGETYHGKVKRIEKFGAFVELFKGKDGLLHISQIAEERINKVEDVFKLGDEVDVRVTEIDNQGRVNLSRKVLLKEQREKLEKEEAKDTANE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y6325_ORYSJ
Sequence: MPLSAGSLRRRPKFAAPLLSPACLHRLSVPGEFAARLDDDDAAGVGEEEEEESGRRAAAVLVVGPLGKVWRVELRRSPAGDGEAWLGGGWSELAAAHGLGEGWGVVLRLERRGVASLRVFDPGFCLARFCTPHAGMRTKDRPRFIKLLQQEDLEKMKIPEKFVQQHLTETYTNNHQNAIIVCPLGKFWRVELQREQPDVLLRDGWAPFLAAHDLSEGNILLFRYEGNMVFTVEVFLQNGCLKEYKTAALYLTDGTEGPSNAPQQSAAKVGVSPVKRKRTRRIEGTCLEGPNRKSRASPISVKVEPHKKHVSIVSQNSFTKEMTAYSIHSLLSVRGTFCSQIGLLEACAITLKISMKKKGSWRVAFKTANTYGYINGPGWRKFCLENELEVQRR
What are the official names of this protein?
Putative B3 domain-containing protein Os06g0632500.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYFA_MYCLE
Sequence: MLSSEALAKAVNTARQAIALAVNLDALALIKAEHLGDRSPLALARQALASLPKIDRAAVGKQVNTARSEVQRDYDERLATLQAERDAAVLVTERIDVTLPSTRQPTGARHPITILAEHIADTFIAMGWELVDGPEVETEQFNFDALNFPADHPARSEQDTFYIAPDGSRQLLRTHTSPVQVRTLLERELPVYVISIGRAFRTDEVDATHTPVFHQVEGLAVDRGLSMAHLRGTLDIFARAEFGPSTRTRIRPHFFPFTEPSAEVDVWFASKKDGADWVEWGGCGMVHPNVLRATGIDPDIYSGFAFGMGLERTLQFRNSIPNMRDMVEGDVRFSLPFGVGA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_BAUCH
Sequence: MSHMTPSEIVNELDDYIIGQHNAKRAVAIALRNRWRRMQLDETLRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRLQSMEKNRFRAEERAEERILDVLIPQPTPNNWDKIEENNSSEPSSTRQHFRKKLREGQLNEKEIEINLAATPIGVEIMAPPGMEEMTNQLQSMFKNLAGQKQKSRKMKIKEAMKLLIEEEAAKLVNQEKIKEKAIEAVEQNGIVFIDEIDKICKRGDVSGPDVSSEGVQRDLLPLVEGCTVSTKHGMVKTDYILFIASGAFQVASPSDLIPELQGRLPIRVELEALTPKDFQLILTEPNASLTMQYIALMATEGVSISFTEDGIKRIAETAWQVNERTENIGARRLHTILELLMEDISYDASEWHGKTISIDADYVRSHLDDLVSDEDFSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_THEFY
Sequence: MIKVGVFGALGRMGSEVVKAVEAADDTELVAGIDVGDDRGKVLGADVVVDFTHPDAVMDNLRWLIEHGIHAVVGTTGFDDARLAEVRRMLDAKPGVNVLIAPNFGIAAVLMMHFAAKAAPYFESAEIIELHHPNKADAPSGTAYRTAELIGAARAHAGLGDAPDATTSELPGARGAQVDGVRVHALRITGMIAHQEVVFGTHGETLRIRHDSMNRESFMPGVLLGVRKVASLPDRLTVGLESLLGL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_SHELP
Sequence: MAKFEAPQKDDLQEKLVAVNRVSKVVKGGRIFSFTALTVVGDGNGKVGYGYGKAREVPAAIQKAMEKARRNIVSVELVNGTLHHPVKGRHTGSRVYMQPASEGTGIIAGGAMRAVLEVAGVHNVLSKAYGSTNPINIVRATVDALVHMKSPAQIAAKRGLNVDEIRG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: LPXH_NEIM0
Sequence: MKPAYFISDLHLSEKHPELTALLLRFLRSSAAGQARAVYILGDLFDFWVGDDEVSELNTSVAREIRKLSDKGVAVFFVRGNRDFLIGQDFCRQAGMTLLPDYSVLDLFGCKTLICHGDTLCTDDRAYQRFRKIVHRKRLQKLFLMLPLKWRTRLAAKIRRVSKMEKQVKPADIMDVNAAFTARQVRAFNAERLIHGHTHREHIHHENGFTRIVLGDWHNDYASILRVDGDGAVFVPLEKY
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NFKB2_XENLA
Sequence: MMSVLKIENFDPYSCNGIEDRNGMGYSTALLNPIVLGQDLLMSYLSIIEQPKQRGFRFRYVCEGPSHRGLPGASSEKGKKTFPTVKIFNYVGMARIEVDLVTHTDPPRVHAHSLVGKHSNKTGNCIVTVGPEDMTAQFNNLGIVHVTKKSQTEILKEKMKRNILRNTGRNTLTEVEERKIEQEVKDLKKVTDLSIVRLKFTAYLPDSNGAYTLALPPVISDPIHDSKSPGASNLRISRMDKTAGSVKGGDEVYLLCDKVQKDDIEVQFYEDDENGWHAFGDFAPTDVHKQYAIVFRTPPYHTQKIDRPVTVFLQLKRKKGGDVSDSKQFTYYPLEQDKEEVERKRRKDLPTFNNHFYGGGSPMGGAPPGSSFGQGGGSNINYQYTGMNSAFYMSSPAGGGYHSSGHMMKHCSATNSSEKNQQPSISIKKEGEEASACSQTDSATTAQKEAQCQMIMRQANLRMLSLTQRTSRALLDYATTADPRMLLAVQRHLTATQDENGDTPLHLAVIHGQSSVIEQLVQIILSIPNQQILNMSNHLQQTPLHLGVITKQYSVVAFLLKAGADPTILDRYGNSVLHLAVQSEDDKMLGVLLKYPSVGQKNLINMPDYHGLSPVHWSVKMKNEKCLVLLVKAGANVNSAERKSGKSPLHIAVEMDNLNLAVFLVKKLHADINAKTYGGNTPLHLAASRGSPMLTRMLVNEGANVLSENDEPVNKLPSCNSDTSESDSDVQMDTDSDHHGDSDTDSSTAVDSECEHSAEEMHRREQRNIRPHCAMKRRYSGHTAVDLTKSQKVRDILSKHTPGSASWKQKGPEPVNVLALETNTVQRLEKLLNEGQTGADWTELASRLRLQSLVETYKNTSSPTESLLRNYELAGGNLKELINTLQSMGLNEGVELLCKSETYAKHHSPAESKNDSAYESQSMEVDQSSGNLMDDSQKQTIPVSAAELCPTTEPTIGQ
What is the function of this protein?
Appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins and generation of p52 by a cotranslational processing.  The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.  p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.  In concert with RELB, may play a role in the regulation of the circadian clock (By similarity).
What are the official names of this protein?
Nuclear factor NF-kappa-B p100 subunit, DNA-binding factor KBF2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Protein: CASP3_ORYSI
Sequence: MEGSEEHGETSKAPLSRGVSKGVSILDVILRFVAIIGTLASAIAMGTTNQTLPFFTQFIRFKAQYSDLPTLTFFVVANSIVSAYLILSLPLSIVHVIRSRAKYSRLILIFFDAAMLALVTAGASAAAAIVYLAHKGNARANWLAICQQFDSFCERISGSLIGSFAAMVVLVLLIFLSAIALARR
What is the function of this protein?
Regulates membrane-cell wall junctions and localized cell wall deposition.  Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion (By similarity).
What are the official names of this protein?
Casparian strip membrane protein 3, OsCASP3.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Very restricted localization following a belt shape within the plasma membrane which coincides with the position of the Casparian strip membrane domain in the root endodermis.
Protein: RL32_ACHLA
Sequence: MAVPFRRQSKGRKRRRRSHYKLKTPTIVVDPQTGEFTLPHRVTPNSGYYKGQLVLAKKVKKED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: RS16_EHRRG
Sequence: MSVKIRLARFGAKKRPFYRVVVADSRVARDGRFIELLGFYNPMLPKEHPSFLKVKIDRLKYWLSVGAQPTERISWFIKKGLISTEAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: MFTE_MYCTO
Sequence: MNSSYHRRVPVVGELGSATSSQLPSTSPSIVIPLGSTEQHGPHLPLDTDTRIATAVARTVTARLHAEDLPIAQEEWLMAPAIAYGASGEHQRFAGTISIGTEALTMLLVEYGRSAACWARRLVFVNGHGGNVGALTRAVGLLRAEGRDAGWCPCTCPGGDPHAGHTETSVLLHLSPADVRTERWRAGNRAPLPVLLPSMRRGGVAAVSETGVLGDPTTATAAEGRRIFAAMVDDCVRRVARWMPQPDGMLT
What is the function of this protein?
Peptidase involved in the biosynthesis of the enzyme cofactor mycofactocin (MFT).  Catalyzes cleavage of the MftC-modified MftA peptide to liberate its final two residues, which consist of a cross-linked valine-decarboxylated tyrosine dipeptide (named 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one or ADHP).
What are the official names of this protein?
Mycofactocin precursor peptide peptidase.
What is the protein family that this protein belongs to?
Belongs to the creatininase superfamily.
Protein: MURG_MYCBO
Sequence: MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSLSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTPRGLETRLVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAVATGAGARTTT
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GMHA_ACTP2
Sequence: MYLAQIKAELQEAADVLDKFMSDEKNIQLIQDAALLISNSFKQGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHLSCVSNDFGYEYVFSRYLEAVGQKGDVLFGLSTSGNSKNVLNAIKVAKEKGMKVIAMTGKDGGQMAGLADVEIRVPHFRYADRTQEIHIKVIHILMMLIEFEMAKQA
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM56_HALMA
Sequence: MKDSPQVTVLRLGHRPGRDERMTTHVGLTARALGADKVVLANAARNQADTVIDITDRFGGPFDVASTEEPKRLIRDFEGRVVHLTMYGEPVQEVEADVREANTAEPLLVVVGAEKVPFEVYEHADWNVGVTNQPHSEVASLAVFLDRLFEGRELDREWENPDRVVVPQETGKRVVDPDEE
What is the function of this protein?
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
What are the official names of this protein?
tRNA (cytidine(56)-2'-O)-methyltransferase, tRNA ribose 2'-O-methyltransferase aTrm56.
What is the protein family that this protein belongs to?
Belongs to the aTrm56 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_PHOV8
Sequence: MTRIFLIGYMGAGKTTLGKAFAREMSLNFIDLDWFIEERFHKTVQQLFLERGEDGFRELERKMLHEVAEFEDVVVSTGGGTPCFFDNMEYMNDCGDTVFLDVEPAVLFRRLRVAKQQRPLLANKSDEELMDFICEALQKRHPFYSKAKHLFKADELEDKRQIQASVDSLRKKLNK
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYST2_DICDI
Sequence: MVSSLKDMLKYDEGEKLEMYKDTEGNYTIGIGHLITKNKDKNEAIKILEGEIGHTVKLNSKKEPEISSSESESLFEKDKSVAINSIENSSTLSTIYNNLDSNRKMALANMVFQMGASNVSKFKKSLKLIEEKKWAEAAIELKNSTWNTQTPKRSNRVISVFETGTLKEYK
What are the official names of this protein?
Probable T4-type lysozyme 2, Muramidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 24 family.
Protein: SEPF_STRP1
Sequence: MAFKDTFNKMISYFDTDEVNEVEEDVAASTDNVIPRSQQSVRASSHPKQEPRNNHVQQDHQARSQEQTRSQMHPKHGTSERYYQQSQPKEGHEMVDRRKRMSTSSIANRREQYQQSTCSDQTTIALKYPRKYEDAQEIVDLLIVNECVLIDFQFMLDAQARRCLDFIDGASKVLYGSLQKVGSSMYLLAPSNVSVNIEEMTIPHTTQDIGFDFDMKRR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: PYRG_ANAPZ
Sequence: MVGKLNPTRFIFVTGGVVSSLGKGLAAASIGALLQARGFSVRLRKLDPYLNVDPGTMSPAQHGEVFVTSDGGETDLDLGHYERFTGVMKTRADNVTAGKIYHELIVKERRGDYLGQTVQVIPHVIDLIISCILHNDAGADFVICEIGGTVGDIESQPFLEAIRQVSYRLSKNLTIFVHLTLVPYIGAVGELKTKPTQHSVKELSSLGIQPDIVLYRSRAQLPQYQCAKIANFCNVAEDNIIAALDVSNIYMLPVMYHEHRLDTQILKHFDVDSPEPDLTQWENVLRMSETASDRIVIAIVGKYVTSLDAYTSLEEALRHAGLHSGIRVEIKWVDARLPASEIDLTDADAILIPGGFGDNGIGTKICAIEYARVNNIPMLGICLGMQLAVIEFALNVAGIEDANSTEFKSDCKNPVVCELPGLQVGDEYKMGGSMRLGSYTCNLAPGSRIMSIYDSSTVVERRRHRYGINPEYRDVLSKCGLAFTGAAEDRDLPEVLELPDHPWFIGVQFHPEFQSTPFKSHPLFLSFVTSTLQVKKASSRS
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: SOSB2_MOUSE
Sequence: MHGVNDPPLFIKDIKAGLKNLNVVFIVLEIGRVTKTKDGHEVRSCKVADRTGSITISVWDEIGGLIQTGDIIRLTRGYASMWKGCLTLYTGRGGELQKIGEFCMVYSEVPNFSEPNPDYRGQQNRGVQNEQKDKLSTNTFGPVGNGDQTGPESRGYHLPYGRSNGPGPISPQLPGTPSSQTVRTTISNARDPRRAFKR
What is the function of this protein?
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint.  In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines.  The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability.  Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity).
What are the official names of this protein?
SOSS complex subunit B2, Nucleic acid-binding protein 1, Oligonucleotide/oligosaccharide-binding fold-containing protein 2A, Sensor of single-strand DNA complex subunit B2, Sensor of ssDNA subunit B2, SOSS-B2, Single-stranded DNA-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the SOSS-B family. SOSS-B2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes to nuclear foci following DNA damage.