PharMolix/UniProtQA huggingface dataset:
Protein: HIS5_GEOMG
Sequence: MATIAIIDYGMGNLRSVQKGFEKVGFEAVVTADPKVVLEAEKVVLPGVGAFRDCMRNLEQGGFVEPILTVIQDGRPFLGICVGMQLLFTDSVEFGLYQGLNVIPGHVLRFPEGMRERGEDLKVPHMGWNQLSIKRRPSAFSDVEDGANVYFVHSFYAKPDEEGVVAATSSYGIDFCAAVWKDNIVATQFHPEKSQAVGLSILKNFALSKA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AZOR1_BACCR
Sequence: MSKVLFVKANDRPAEQAVSSKMYETFVSTYKEANPNTEITELDLFALDLPYYGNIAISGGYKRSQGMELTAEEEKAVATVDQYLNQFLEADKVVFAFPLWNFTVPAPLITYISYLSQAGKTFKYTANGPEGLVGGKKVVVLGARGSDYSSEQMAPMEMAVNYVTTVLGFWGITNPETVVIEGHNQYPDRSQQIVEEGLENVKKVAAKF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 1, Azo-dye reductase 1, FMN-dependent NADH-azo compound oxidoreductase 1, FMN-dependent NADH-azoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: PCDA9_HUMAN
Sequence: MLYSSRGDPEGQPLLLSLLILAMWVVGSGQLHYSVPEEAEHGTFVGRIAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVESGQAPKSSSRASVGATGPEVTLVDVNVYLIIAICAVSSLLVLTLLLYTVLRCSAMPTEGECAPGKPTLVCSSAVGSWSYSQQRRQRVCSGEGKQKTDLMAFSPGLSPCAGSTERTGEPSASSDSTGKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin alpha-9, PCDH-alpha-9.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HSLU_CALS4
Sequence: MRNVKNYTPKEIVAELDKYIVGQKEAKKSVAVALRNRYRRSLLPEDFKEEVTPKNILMVGPTGVGKTEIARRIAKLVEAPFVKVEATKFTEVGYVGRDVDSMVRDLVEAAVRMVKEEKLKAVTEKAKKLAEERLIDYLLGKKKKQPKNPFEMIFNYPSSERTEEPDNVDSYKREEIRQRLRSGELDNHMVEIEVTDTTPPMLEMYTNLGAEELNITLQDMFSDLLPKKKKLRKVTVAEAKKILEAEEAQNLIDMDEVIEEAVKRAENDGIIFIDEIDKIASTGYSAGPDVSREGVQRDLLPIIEGCTVMTKYGPVKTDYILFIAAGAFNVAKVSDLIPELQGRFPIRVNLKPLTKEDFVRILKEPKNALTKQYQELLRTEGVEIKYTEEAIETIAEVAYLINQQSEDIGARRLHTVMEKLFEDLSFHAPELSGQEIVITADYVKEQLKDSLNKYEVNKYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXA_PASMU
Sequence: MIHPTAQIHPTSIVEAGAKIGENVVIGPFCLVGAEVEIGAGTILHSHVVVKGITKIGRDNQIFQFASIGDTNQDLKYQGEPTRTIIGDRNRIRESVTIHRGTAQGGSVTVIGDDNLLMVNVHVAHDCRIKNRCILANNATLAGHVELDDFVIVGGMSAIHQFVIVGAHVMLGGGSMVSQDVPPYVMAQGNHAKPFGVNIEGLKRRGFDKPTLHAIRNVYKLIYRSGKTLEEVMPEIEQVAAKESAISFFVEFFKRSTRGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_PARP8
Sequence: MSRIQSTFAALAAQGKKGLIPFMTAGDPDPARTVEFMHALAKGGADVIELGVPFSDPMADGPVIQQSSERALAKGVSLRHVLADVKRFRESDDKTPVVLMGYANPIERMGADAFAAAAKDAGVDGVLVVDYPPEESANFAETMKAAGIDPIFLLAPTSTDERIAEVGKIASGYVYYVSLKGVTGAANLDVLSIAGKIPAIKSRVPLPVGVGFGIRDAQSARAVAEVSDAVVIGSRIVQLLEEAAPQSAAGKLTNFIKEIRQALDSIGATAG
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: FTSB_SALG2
Sequence: MGKLTLLLLALLVWLQYSLWFGKNGIHDYSRVNDDVVAQQATNAKLKARNDQLFAEIDDLNGGQEAIEERARNELSMTKPGETFYRLVPDASKRAATAGQTHR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: IF2G_PYRAB
Sequence: MGEKRKSRQAEVNIGMVGHVDHGKTTLTKALTGVWTDTHSEELRRGITIKIGFADAEIRRCPNCGRYSTSPVCPYCGHETEFVRRVSFIDAPGHEALMTTMLAGASLMDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEKALENYRQIKEFIEGTVAENAPIIPISALHGANIDVLVKAIEDFIPTPKRDPNKPPKMLVLRSFDVNKPGTPPEKLVGGVLGGSIVQGKLKVGDEIEIRPGVPYEEHGRIKYEPITTEIVSLQAGGQFVEEAYPGGLVGVGTKLDPYLTKGDLMAGNVVGKPGKLPPVWDSLRLEVHLLERVVGTEQELKVEPIKRKEVLLLNVGTARTMGLVTGLGKDEIEVKLQIPVCAEPGDRVAISRQIGSRWRLIGYGIIKE
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
What are the official names of this protein?
Translation initiation factor 2 subunit gamma, aIF2-gamma, eIF-2-gamma.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Protein: Y459_RICPR
Sequence: MIDKSSADILEISAKCGYLTGLLKNVYRSANIIVTDMSPLLLDSFDHNHKLLIDDENLEFQKDSFDLIIYSLGLHWINDVQRFLYNIRTFLKSDGIFIGNFVGGDSLKNLRKSLIDNEIASGFKHSPHISPFIHFDHVPMLLLHAGFSEVIVDYENIALKFENPIVLMKEIKNIGESNALNSQHNYAISKKMFSLLKNYINVFEDNITLISFIAAPNKNSLRLKLL
What are the official names of this protein?
Putative methyltransferase RP459.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: PSAB_THAPS
Sequence: MATKFPKFSQALAQDPATRRIWYGIATAHDLEAHDGMTEENLYQKIFASHFGHLAIIFLWTSGNLFHVAWQGNFEKWVSNPLKTRPIAHSIWDPHFGESALKAFSKGNTYPVNITFSGLYQWWYTIGFRTNQELYKGSIGLLLLASVLLIAGWLHLQPKFRPSLSWFKNNESRLNHHLSGLLGFSSLAWTGHLVHVAIPASRGVHVGWDNFLTTPPHPAGLTPFFTGNWTVYAENPDSATHVFNTSEGSGTAILTFLGGFHPQTQSLWLSDMAHHHLAIAVVFIVAGHMYRTNFGIGHNMKEILDAHRPPGGRLGAGHVGLFETITNSLHMQLGLALACLGVATSLTAQHMYALTPYAYLSKDFTTEAALYTHHQYIAGFLMVGAFAHGAIFFVRDYDPELNKNNVLARMLEHKEAIISHLSWASLFLGFHTLGLYIHNDTVVAFGQPEKQILFEPLFAEYIQAASGKAVYQFNVLLASSTSPATAAGNQVWLPGWLEAINNPKTDLFLKIGPGDFLVHHAIALGLHVTALILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAMFWMLNTIGWVTFYWHWKHMTIWGGNPGQFDESSNYIMGWLRDYLWLNSSPLINGYNPFGMNNLSVWSWMFLFGHLIWATGFMFLISWRGYWQELIETLVWAHERTPLANLIRWRDKPVALSIVQARLVGLVHFSVGYILTYAAFVIASTSGKFA
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PSI-B, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: DEP4_ALTBR
Sequence: MESFDIVVVGAGWYGLMAARTYLELAPETNLLIVDDSSTVGGVWSKERIYPSLFAQISHPLFEYSFYPMPKDDISPDGFVSGKTIHNYLTSFTRDHNLLPRLRLNTRVERVRRGPSDAGGWVLDIKEGNPLLCHKLIYATGANSSPIIPTWPRQTFEQPVIHSLDLGKHQDYIAKSVETATVVGRSKSSYDAVYHLLCEGKRVNWVMRDGLSGPFSLYAPTFMGLWNIADHISTRFASSFSPCIMNTSGFCYNFLQRNAVGRTLTNVYWRAANYLSVSHAEYWRTPNAEKLRPRPYSDGVFWGSGGIGIATAPDFWKVFHRGNITIHSTEIDSLSHGDVVNLKNGYSLATDIVIHCTGFDKGYTTFDPELREELGLQYNSKSISRWSLLDAKAEQTVDELLPYLRTAPLQDMDPDASSRPEQGPNRHFRRLVVPELAARGDRSILFPGHIHSAFTPLAAELQALWGVSWMLGWRELPPQEEMELEAATFNAWTRKRYLEQGKKHSYFIYDYIPYIDTLMRDLGLNPYRKSSVFEEWFVRYKPSDYGTILDEYRDIRRLSLECLQGTGGFAERTNGHGVNMK
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099).  The reducing polyketide synthase DEP5 is the central enzyme in depudecin biosynthesis by yielding the backbone polyketide chain (PubMed:19737099).  The monooxygenases DEP2 and DEP4, as well as the uncharacterized protein DEP1, then act as tailoring enzymes to modify the intermediate polyketide chain into depudecin (PubMed:19737099).
What are the official names of this protein?
FAD-dependent monooxygenase DEP4, Depudecin biosynthesis cluster protein 1.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: Y055_AFV1Y
Sequence: MPLDTWKSCCPQAVMYQSGDVYVISGCGVEVKYKDLKLATREFCKKVALKRVRKK
What are the official names of this protein?
Uncharacterized protein ORF55.
Protein: STX11_HUMAN
Sequence: MKDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHILESLYRDIRDIQDENQLLVADVKRLGKQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVIHCKLRAMKELSEAAEAQHGPHSAVARISRAQYNALTLTFQRAMHDYNQAEMKQRDNCKIRIQRQLEIMGKEVSGDQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLESRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTVDYTGQAKAQVRKAVQYEEKNPCRTLCCFCCPCLK
What is the function of this protein?
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
What are the official names of this protein?
Syntaxin-11.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Protein: CNTF_MOUSE
Sequence: MAFAEQSPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNISLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLTLQVSAFAYQLEELMALLEQKVPEKEADGMPVTIGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHHMGISAHESHYGAKQM
What is the function of this protein?
CNTF is a survival factor for various neuronal cell types.  Seems to prevent the degeneration of motor axons after axotomy.
What are the official names of this protein?
Ciliary neurotrophic factor, CNTF.
What is the protein family that this protein belongs to?
Belongs to the CNTF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK33_CERDE
Sequence: MAKGKDVRVRVILECTSCARNGGNKESRGISRYITQKNRHNTPSRLELRKFCPYCYKHTTHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y708_GEOTN
Sequence: MSNKVTVERAERKDGRLWLYADNVPVPLVHVTPKRHMLVDSDALAFVYILETDDRFLYVIIPKQWWPELKAAFAEGEPIWLESEGMALELEQFGEELAYLLENIRDNANYGETFEQAVQEVFFAE
What are the official names of this protein?
UPF0738 protein GTNG_0708.
What is the protein family that this protein belongs to?
Belongs to the UPF0738 family.
Protein: YFLA_METVO
Sequence: MPNISEIIDSINRRSMAEIIT
What are the official names of this protein?
Uncharacterized protein in flaB3 3'region.
Protein: AT1B1_MACFA
Sequence: MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGEFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPGMKYNANVLPVQCTGKRDEDKEKIGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
What is the function of this protein?
Involved in cell adhesion and establishing epithelial cell polarity.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-dependent ATPase subunit beta-1.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell membrane, sarcolemma. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.
Protein: ARP2_PLAFA
Sequence: MNNEIVNSTIDGVLNTKLHIQNIPPHITDVHLRSLLGNVGFIKDICYFNKSKKQMNNNNFANKKIYNTALVTFNTHEEALNVLKNIKNLIDTSGEERNIDAKFAVPNVSINNNNNNNNSNTFFQKNNMNNTNFSQGSTNYGSNYNSENFQGNNNMNNYNFYNNNSSNNNNNNQTNTQNNFMNRNMKNKNMNNNNNNNNSNNNMMMNMNFNNNQQMNNNPMLNQNNFMLNNNNNYNNNAKNVNDMYRDGEMSPNHLNNNNNNINNNNNNNNNNNNNNNVMFRQNNSHLAQMYQANDNSLEDVENVDGLSLWEMYKDKNNNIFYYNNLTKHANGINLFTQTNYSSITIMKKQNKMDLVEVTYLFSTYLVNGQTLIYSNISVVLVILYHQKFKETVLGRNSGFGFVSYDNVISAQHAIQFMNGYFVNNKYLKVQLKKGETVENTNS
What are the official names of this protein?
Clustered-asparagine-rich protein, CARP.
Protein: DHR11_MOUSE
Sequence: MTRAGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGMARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNIDDGHIININSMCGHRVPPQSVIHFYSATKYAVTALTEGLRQELLEAQTHIRATCISPGLVETQFAFKLHDKDPGEAAATYEHIKCLRPEDVAEAVIYVLSTPPHVQVGDIQMRPTEQVT
What is the function of this protein?
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites.  Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids.  May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
What are the official names of this protein?
Dehydrogenase/reductase SDR family member 11, 17-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, Estradiol 17-beta-dehydrogenase, Short-chain dehydrogenase/reductase family 24C member 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMG_SHEPA
Sequence: MLSAQLNDYLAEVGLTATEQQKKQLVDFVGMLNKWNKAFNLTSVRDPEQMLIRHIMDSLVVSPHLKGSRFIDVGTGPGLPGIPLAILNPDKEFVLLDSLGKRIRFQKQVQFELGINNISSIESRVEAYQPKDLFDGVLSRAFASIQDMLHWCHHLPKADGCFYALKGQLSEEEMSQMPAGFVVTDTIELKVPKLDEQRHLLRVIKQD
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUGA_CONQU
Sequence: DCQPCGHNVCC
What is the function of this protein?
Causes reversible depression symptom in mice when injected intracranially.
What are the official names of this protein?
Conotoxin qc16a.
What are the subcellular locations of this protein?
Secreted.
Protein: SH3P1_ARATH
Sequence: MEAIRKQAAKLREQVARQQQAVLKHLGHVNADAVVVDEEELHCHQKLQDLYSSTKAAKRLQRNIVRGLEGFIATGTKVVEIGLKFAEDFKKYGDENPDANTPLSRVAHHFGTSYKSVEGERETLLGVLSEQVCEPIRTMIYSAPLEDARHLVNHYDRLRQEVEAQATDVLRRRSKLKESDISEEAYIKLKNSESRLAELKSSMKTLGKEATKAMLEVDDQQQNVTSQRLRALVEAERSYHRNALDILDKLHSEMIAEEEAIGSSPKSLPLHIEDSASLPQQEPNSNSSGEIKSNPLGKIKASRREEIKSNPQEVTKPSPKDEMKSSPQEETKSNHQKEIKSSPQEEIKKSNGSDDHHNHQLLSQNDSYFLAKVVHPFDAQAPGELSLAVDDYVIVRQVAGTGWSEGEYKGKAGWFPSAYVEKQEKAPASKIVESNSKQQ
What is the function of this protein?
Lipid binding protein bound strongly to phosphatidic acid, phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate.  Binds actin in vitro.  Involved in trafficking and modification of clathrin-coated vesicles.
What are the official names of this protein?
SH3 domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle. Cell membrane. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Cytoplasmic vesicle.
Protein: RSMA_POLNA
Sequence: MKHIARKRFGQHFLTDRLIIEGIVEAIAPLPGQPMVEIGPGLAAMTRPLVERLGHLTVIELDRDLARQLRSNPQLTVIESDVLRVDFLQLAEQVQSAGALRGAASQTPSPCKLRVVGNLPYNISTPILFHLLDAVEVIEDQHFMLQKEVIDRMVAMPSTSDYGRLSVMLQWRYAMENVLYVPPQSFDPPPRVDSAIVRMVPHAEPARLDVKLLSELVRVAFSQRRKLLRHTLGQWLEQHAFSGEFDVKRRAEEVPVAEYLALAQQVQTGTAQPEKIELL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COQ6_BOVIN
Sequence: MAAQLARVRWGTVFAAAQKGPRVSCRRWAGASADNVYDVVVSGGGLVGAAMACALGHDIHFCDKKILLLEAGPKKVLEKLPETYSNRVSSISPGSATLLSSFGAWDHICNMRCRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDQVTVLYKSKAVSYTWPYPFSMADSSPWVHITLGDGRTLQTKLLIGADGHNSGVRQAAGIRNVSWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMEEEEFVDAINSAFWSDVNHTDFIDSAGSMLQSAVAFLKPTRVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPRLALIGDAAHRVHPLAGQGVNMGFGDISSLLHHLSTAAFNGKDLGSMSHLTSYETDRQRHNTALLAATDLLKRLYSTRATLVVLLRTWGLQATNAVSPLKEQIMAFASK
What is the function of this protein?
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis.  Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid.  The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
What are the official names of this protein?
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial, Coenzyme Q10 monooxygenase 6.
What is the protein family that this protein belongs to?
Belongs to the UbiH/COQ6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Golgi apparatus. Cell projection. Note=Localizes to cell processes and Golgi apparatus in podocytes.
Protein: ATPA_RICB8
Sequence: MKLKPIEVADILQKEIANINCLSELEEVGQVINVGDGIAKIYGLANVQSGEVVEFESGVKGLVLNLENDSVDAVIMGDDNQVQQGDKVKRTKEVLEVLVGTALLGRVVDALGNPIDGKGDIKSKEYRHIEMKAPGIIDRASVSEPVQTGIKVIDLLIPIGRGQRELIIGDRQTGKTAIAIDTIINQKKAHSLNDEKDKIYCIYVAIGQKRSSVAQIVKKLEDAGAMDYTIIVSATASEAAALQFVAPYAACSMGEYFRDNGKHALIIYDDLSKHAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLECAAKMSEEKGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESELFYKGIRPAVNVGISVSRVGSAAQIKAMKQVAGSIKLELAQFRELESFLQFGSDLDSATKAQIEHGKRLVEILKQAQYHPFSVEEQIISIYAGTKKYLINIPVERIKEFEEKMLSEIKQNQKDILESIKSEKRITEENEQKLKTFLENFVKDFVKID
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GLYA_LEUCK
Sequence: MSFKELDPEVWSAIQQEGARQNRTIELIASENFASKGVRAAQGSVLTNKYAEGYPYKRYYGGTEYVDVVEQLAIDRLKALFGAEYANVQPHSGSQANAAAYMAFLQPGDKILGMDLDAGGHLTHGAKVSFSGKMYQSYTYGLDAESEQLDYEAIAKQAREVQPQMIVAGASAYSRIIDFNKFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVGIADVVTSTTHKTLRGPRGGVILSQEKYAKKINSAIFPGSQGGPLEHVIAGKAIAFGEALQPEFKAYAAQIIKNAQAMAEVFTATEDIRVVAGGTDNHLFNLDLTKTGLNGKQTQELLDSVSITTNKEALPNETLSPFITSGIRIGTPAITTRGFNEADARHVAELIVTAIHHYDDAKVLKDVKKEAEILAMTHLFE
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB28_CROS5
Sequence: MAQIQFSRGVSEPVVPEVRLTRAKSGNSGTATFRFESPTILDAESTDDITGMYLVDEEGEIVTREVKGKFINGKPTSVEAILIMNSQDEWDRFMRFMERYAQENGLGFSKA
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SSRP_RICCN
Sequence: MTEYKKVIAQNKKALFNYFIEERLEAGIVLKGSEVRSLRQGKASIEESHAADTRHEVFLYNCHIAEYEKANRFNHATRRPRKLLLHTKEIKKIIGRIRIKGYTLVALSMYFNKKNKVKVELGIAKGKKLHDKRESIKEKDWKRDQSRLIRQK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.