Protein: FOGA_ASPRC
Sequence: MNDDPPCIVGMACRLPGDVRSPSQLWDLVINQKTGQGPTPPIRYNVDGYYHPDGNRSGGINVPGGYFINEDIRQFDNGFFGINNLEATYMDPQQRKLLEVVFECFESTGASMKSMSGSNTGVYVGNFSVDYQPMQTRDADYLHRYTSTGSGATIMSNRISHVFNLHGPSFTLDTACSSSVYALHQALTAIKVGDCESAVVASANLIMSPELHIGAAKSGVLSPTGTCHTFDASADGYGRAEGVNAIYVKRLSAALRDGNQIRAIVRGSAVNANGRTPGIALPSGNLQEAVMRKAYQNAGLDFAETDYVECHGTGTPVGDPIEVDAVGRCFFRPQGQAPLLIGSVKTNIGHSEAASGLSSVLKVVTAFEKGQIPPTHGLVKLNPKLIPILEQRNLKVVTQADQWPRALRRASVNSFGYGGANAHVILESADSYLSQYFPGRLVTQKRRIENSDQVVVLPVSAASSKSLDIRVQDISQAVSKLFDAENLQGLAYTLTNRRDHLRHKSFLLAKYEGSGKLVEAVEDANNSSDREGLPFGFVFTGQGAQYAGMAKELLAHNRQFRNTIHRLDDVLKALPDPYAPDWTLEQTLLDGPSESRINEVTRSQPICTALQVGLVDLLRSWGVSPTAVVGHSSGEIAAAYAAGLLNSTQAILVAYFRGYSVGKLQSQGTMMAAGVSAQTAKSLIEAKDLQENVRVACVNAPESVTLSGASDGIEALRAEFQDQKKFARKLETGGRAYHSHMMKEIGALYQDLLTPLFAVANSEVPAAARMYSSVGHSTDDLRVLEGHTDWAAYWRQNLEQPVQFSGALASLAEKEGSKLHLIEVGPHSALKGPIQQIRTSIGLDKNSLPYAPSLVRKEDADECLKKLAGTLFVHGHVLDWNKINDLPESGHELVPLHDLAPYPWDYSAPLNWAEPRTSVELRNRKYLRHELLGTFALTGNGIDFTWRNLIRPKEMPWFSDHKLETSVVFPAAGYLAVAIEAVSQVTETRGRLDVAFEFRNVNITAALIVPPDSDPAAKDLELHTTMSLRKLSTVNTSADWHDFAVSSWAAGETTIHCAGSIRVVEPLTESVKHVTTTTVDNDQSFEASPTNRWYQKWDDEGLCFGPYFQSLTSLRTDSERTRSEAIASLRLAPEISSKSYIDSYPVHPITIDACFQAAILGGTAGHLPSLRAWMPVFISECRIQPSSLATSPELEAVIHARSEEVGFSSRRIDATLRDPHGVPVVNLRDARMSLYTGKSSAVQSSSDGKNTNPIDKYMQRQPTLRVHWKPDVARLHPGIERQLQEYVAAFVDQQPLDSDLRDDESIAVIAALVDLAGHKHPRMRVLELGGDDVGYKAKQWLGILNKETAFARCQSWQAGVLDGNGEIVVEGDGEDSSPFDVVVIPRNSSSKQIWSQDPESIASLVSDNGIIVARKSNAAVDVLKALKFNVLPIGQSVILALRPPQWTSLQGRNALIVLGRNPSSTVAEFANTLAAYLRDQAGVALASIVPLDRIDTTDISENDVAISLLETEREFLATISPEDMDRLRAITDVVRDLLWVTGANMLGSVPDPNLTLSNGLSRALMLEQPALRYSVLDIGPVSLLSSTPNAIGTCENALRALAINQEKDDSEFIQRDGILHISRFGPDQDVNSLFRRRLEPLGSLERQTLATAGIARLSVGRPGATDSMFFQQLASTAKTVPEAGYVDIEVKAVGLNAKDVYAIAGRVETRNLTTAIDFSGIITAVGEGVEHLSVGDRVVAWAPNHFTTTERVPAGSVHKLLDHEELTIMSTLITVYGTALYAFNHIAHLRAGESVLIHAGSGGLGFAAITLAQKRGAVVYTTAGSKAKREYLVNELGVPDAHIFNSRDASFVEGILEVTNGRGVDVVLNSLTGDLLHASWACLATFGRFIEVGKRDLVEAGKLDMRVFLRSCTFTAFDLSEFFYAQEPHNRAIWDGLMTQVIELYRAGDIQAPPVKVFGVNEITQAYRTFTQQDRIGKIVISLENPQARIPVVPAAYLSVFDPEKVYLLIGCLGGLGRSLSRWMMSRGARHFVFLGRSGADKPSAQQLVARLQSAGAHVDVVRGDVSRAADVTAAVAASLATGRQIGGVVQAAMGLHEALFTRMPNQAWHTGIDPKWQGTWNLHNALQGHDDALDFFLLTSSVSGTVGTATESNYCAANGFLDAFARWRRSQGKPAVAVGLGMISEVGYLHENPEIEALLLRKGIQPLNEDEFLQVLDLALLSEAAHNPDQAHLLTGLEPAGVRQLKARGFDVSNHGVLTEARAALLAASLAAEQEVLDAQNSTSSSGSNSNTPTTAAPWFKALPGTATSTFASEADAESLNAAILRLIKKRFSNLILMPLEQIDERKALPQFGVDSMIASEFRTWFYTVFKVDIPFLDLMSAQKSLEGLAVVVEGKLVEGWK
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of flavoglaucin and congeners (including aspergin, dihydroauroglaucin and auroglaucin), prenylated salicylaldehyde derivatives carrying a saturated or an unsaturated C-7 side chain (PubMed:32134669).  FogA releases the carboxylic acid (8E,10E,12E)-3,5,7-trihydroxytetradeca-8,10,12-trienoic acid as its product, as well as derivatives with one and two double bonds (PubMed:32134669).  FogA is indeed able to reduce the initial triketide, thus being at least partially responsible for the differently saturated heptyl side chains of flavoglaucin congeners (PubMed:32134669).  The oxidoreductases fogB, fogC and fogD modify the nascent polyketide in fogA-bound form and, together, fogA, fogB, fogC and fogD are necessary for the formation of the aromatic core and the cyclized PKS products are released as salicyl alcohols (PubMed:32134669).  In particular, fogB is responsible for oxidation of a hydroxyl group or reduction of remaining double bond(s) at the C-7 residue whereas fogD is probably involved in the reductive release of the modified PKS products (PubMed:32134669).  The cytochrome P450 monooxygenase fogE is then responsible for the hydroxylation at C-3 of the benzene ring (PubMed:32134669).  The fogE products are substrates of the prenyltransferase fogH and the prenylated benzyl alcohols are subsequently oxidized by the fogF to produce the final aryl aldehydes flavoglaucin and congeners (PubMed:32134669).  The short-chain dehydrogenase fogG does not seem to be involved in the biosynthesis of the prenylated salicylaldehyde derivatives (PubMed:32134669).
What are the official names of this protein?
Highly reducing polyketide synthase fogrA, HRPKS fogA, Flavoglaucin biosynthesis cluster protein A.