PharMolix/UniProtQA huggingface dataset:
Protein: AMIB_HAEIN
Sequence: MKTKILFFLFFSTFSFSIFAAPITIAIDPGHGGKDPGAISRNLGIYEKNVTLSIAKELKALLDKDPHFRGVLTRKSDYYISVPERSEIARKFKANYLISIHADSSKSPDRRGASVWVLSNRRANDEMGQWLEDDEKRSELLGGAGKVLSHNNDKYLDQTVLDLQFGHSQRTGYVLGEHILHHFAKVTTLSRSTPQHASLGVLRSPDIPSVLVETGFLSNSEEEKKLNSQTYRRRIAYMIYEGLVAFHSGKTNTLVKDNLVQNIKQNDIKKSGKNNRTSEQNINEDNIKDSGIRHIVKKGESLGSLSNKYHVKVSDIIKLNQLKRKTLWLNESIKIPDNVEIKNKSLTIKENDFHKKQNSLVNNTNKDLKKEKNTQTNNQKNIIPLYHKVTKNQTLYAISREYNIPVNILLSLNPHLKNGKVITGQKIKLREK
What is the function of this protein?
Cell-wall hydrolase involved in septum cleavage during cell division.
What are the official names of this protein?
Probable N-acetylmuramoyl-L-alanine amidase AmiB.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SYT16_MOUSE
Sequence: MVLTMASQDVQNFFQPLSSWLSRVYEALQQAGDALSASLVLLSKHDSALSDKPEQDLDAAQIQQTYLEDEEQDHDGSPEEASSLFLEEDHFSLSNSDLQDSVQTASPTLGQQAEDSSSVIPPWPSKIPGAPKPQPVLSSIAEEDHHSERQRCGRQHGSGTLEKVNGRKQVNSFGDDEEPSTSSESDEDVTKQFKISVSRSQSFRSGVSEKGKTTELEQKIKCKRLLCTHQEDSAEGSACEDLDRTSQLSYSEILSYEDRPISILPQSPFESRNVRHHGPCRPEMGMVRSLGRPCADGVLETETAFVSRGFEDSYATHSSSLWSPEEQDGTSLQVPHRLLEPISKCGDLDVIFEYRAVTQKLTVTIVRAQGLPDKDRSGVNSWQVHIVLLPSKKQRGKTNIQRGPNPVFKEKVTFTKLEPRDVASCAVRFRLYAARKMTRERMMGEKLFCLSHLHPEGEMKVTLVLEPRSNLSSGESPLSPSVVSHSDSASSTQSLSHGGVPELLVGLSYNATTGRLSVEMIKGSHFRNLAANRAPDTYGKLFLLNCVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISIYSRRTMKRKEMIGWVALGQNSSGEEEQEHWEEMKESKGQQTCRWHTLLES
What is the function of this protein?
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.  Is Ca(2+)-independent.
What are the official names of this protein?
Synaptotagmin-16, Synaptotagmin 14-like protein, Synaptotagmin XIV-related protein.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
Protein: LDHD_STAES
Sequence: MTKIMFFGTRAYEKDMALRWGKKNNIDVTTSTELLSVDTVDQLKDYDGVTTMQFGKLEPEVYPKLESYGIKQIAQRTAGFDMYDLELAKKHEIIISNIPSYSPETIAEYSVSIALQLVRKFPTIEKRVQAHNFTWASPIMSRPVKNMTVAIIGTGRIGAATGKIYAGFGARVVGYDAYPNHSLSFLEYKETVEDAIKDADIISLHVPANKDSFHLFDNNMFKNVKKGAVLVNAARGAVINTPDLIEAVNNGTLSGAAIDTYENEANYFTFDCSNQTIDDPILLDLIRNENILVTPHIAFFSDEAVQNLVEGGLNAALSVINTGTCDTRLN
What are the official names of this protein?
D-lactate dehydrogenase, D-LDH, D-specific 2-hydroxyacid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: PYRD_METPP
Sequence: MPLIPYALTRPFLFGLDAEHAHELTLASIARLQNTPLQCLWQQPRIDDPVTLAGVRFPNRIGLAAGLDKNGRCIDGFGAMGFGFIEVGTVTPKGQPGNPKPRIFRLPQAEALINRLGFNNDGLDAFLANVRRAGFRQGGGVLGLNIGKNAATPIEDAVDDYLLGLEGVYPHADYVTVNISSPNTQNLRSLQSDAALDALLGRLQERRQQLIARHGRSVPMFVKIAPDLDEAQVDVIAATLKKNAVDGVIATNTTLSRDAVRGQAHATEVGGLSGRPVFEASNRVVGQLRAALGAGYPIIGVGGVMSGADARAKRDVGADVVQIYTGLIYRGPALVSEAARALKG
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TXS1C_CUPSA
Sequence: FLAKKVAKTVAKQAAKQGAKYIANKQTE
What are the official names of this protein?
Short cationic peptide-1c, SCP-1c, Cupiennin 1-like peptide-1c, Truncated variant of Cupiennin 1 family.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PPCT_BOVIN
Sequence: MDPGAGAFSEEQFREACAELQRPALSGAAWELLVETQGISVYRLLDQQTGLYAYKVFGVLEDCLPDLLADVYMDLAYRKQWDQYVKELYEKECSGETVVYWQVKYPFPMSNRDYVYVRQRQELDFEGQKVHVILAQSTSEPQFPEKSGVIRVKHYKQRLAIQSDGKRGSKVFMYYFDNPGGQIPSWVINWAAKNGVPNFLKDMVKACQNYKKT
What is the function of this protein?
Catalyzes the transfer of phosphatidylcholine between membranes.  Binds phosphatidylcholine in a tight 1:1 stoichiometric complex.
What are the official names of this protein?
Phosphatidylcholine transfer protein, PC-TP, START domain-containing protein 2, StARD2, StAR-related lipid transfer protein 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_VIBCH
Sequence: MRHYEIVFMVHPDQSEQVAGMIERYTGSITEAGGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEADQAVVDELETAFRFNDAVLRNMIMRTKAAITEPSIMLKAREERVKRDEMKFDADVE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PCKA_WIGBR
Sequence: MKNKENILITLNQVGIEQYSNIIYNPNYDTLFKEETNKNLKGLERCILTKLQAIAVDTGKFTGRSPKDKYYVRDEKTKNIIWWSDDNNHKSNNHPINNETWKDLKKLIANNLNNKKLFVIDAFCGANKKNRLKVRFITDIAWQAHFFKNMFIEPIEQELNKFLQDFTVFSVPKAINKKWKDHKLNSENFIAINLTENTLLIGGTWYGGEIKKGLFSVMNYILPLKNIASMHCSANEGFKKDVALFFGLSGTGKTTLSTDSKRYLIGDDEHGWCKDGVFNFEGGCYAKTINLSEEKEPEIFNAIKKNAILENVMVLKDSNINFFDGTKTENSRVSYPINHIKNIVKPISQSGHPKNIIFLTADAFGVFPFVSKLSYFQGQYYFLSGFTSKLSGTERGIIDPEPTFSSCFGEAFLSLHPTVYAKILLRYIKYYNSKIFLVNTGWNGKRERYSLEYTRSIINAILDDKIEFIDENYIPIFNLKIPKKIEGVPDLFLDPRNFFSSNEEWIKQATILSKKFIKNFKKFSHTKLGKKLIKFEPKINF
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_CHLTB
Sequence: MSEKRKSNKIIGIDLGTTNSCVSVMEGGQPKVIASSEGTRTTPSIVAFKGGETLVGIPAKRQAVTNPEKTLASTKRFIGRKFSEVESEIKTVPYKVAPNSKGDAVFDVEQKLYTPEEIGAQILMKMKETAEAYLGETVTEAVITVPAYFNDSQRASTKDAGRIAGLDVKRIIPEPTAAALAYGIDKEGDKKIAVFDLGGGTFDISILEIGDGVFEVLSTNGDTHLGGDDFDGVIINWMLDEFKKQEGIDLSKDNMALQRLKDAAEKAKIELSGVSSTEINQPFITIDANGPKHLALTLTRAQFEHLASSLIERTKQPCAQALKDAKLSASDIDDVLLVGGMSRMPAVQAVVKEIFGKEPNKGVNPDEVVAIGAAIQGGVLGGEVKDVLLLDVIPLSLGIETLGGVMTPLVERNTTIPTQKKQIFSTAADNQPAVTIVVLQGERPMAKDNKEIGRFDLTDIPPAPRGHPQIEVTFDIDANGILHVSAKDAASGREQKIRIEASSGLKEDEIQQMIRDAELHKEEDKQRKEASDVKNEADGMIFRAEKAVKDYHDKIPAELVKEIEEHIEKVRQAIKEDASTTAIKAASDELSTRMQKIGEAMQAQSASAAASSAANAQGGPNINSEDLKKHSFSTRPPAGGSASSTDNIEDADVEIVDKPE
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TGIF1_HUMAN
Sequence: MVLAQSRVSAGVGSPHCSGSGGGGSDSFPWPASHPGNPQCSFSTAFLASPRLSRGTLAYLPPAPWSSLATPSALLGSSCAPPPPPARCPQPRALSPELGTKAGPRRPHRWELPRSPSQGAQGPAPRRRLLETMKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
What is the function of this protein?
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE).  Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element.  Active transcriptional corepressor of SMAD2.  Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures.  May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
What are the official names of this protein?
Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1.
What is the protein family that this protein belongs to?
Belongs to the TALE/TGIF homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CALL4_BOVIN
Sequence: MAKFLSQDQINEYKECFSLYDKQQRGKIKATDLLTVMRCLGASPTPGEAQRHLQTHRIDRNGELDFSTFLTIMHMQIKQEDPKKEILLAMLMADKEKKGYIMASELRSKLMQLGEKLTHKEVEDLFREAGIEPNGKVKYDEFIQKLTIPVRDY
What are the official names of this protein?
Calmodulin-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: PA_I54A2
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGENLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPIRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDDCKDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: ATPB_TRICV
Sequence: MVKTNINKGYVNQIIGPVLDIEFPSGTLPPIYSALKIETEDGIGTVVEVQQLLGDNKVRAVSMRSTDGLKRGVEARDLGGPISVPVGISTLGRIFNVIGEPVDEQGDVSYDETLPIHREAPAFTELETKPSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYEEMKESGVINENNFKESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGALQERITSTTQGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRNLAAKGIYPAVDPLDSTSTMLQPGIVSGEHYEIAETVKETLQRYKELQDIIAILGIDELSEEDRLTVARARKVERFLSQPFFVAEIFTGSPGKYVSLEETIKGFTMVLKGELDELPEQAFYLVGNIDEAIAKAETLK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: SYA_ALIB4
Sequence: MDIRKEYLEFFRSKGHEVISSMPLVPDDPTLMFTNAGMVQFKDIFTGAVPTPKNKRATSCQLCVRAGGKHNDLENVGYTARHHTLFEMLGNFSFGDYFKEDAIAYAWEFVTVNLALPIDKLWVTVHNNDDEAFDIWSKYINPSRIMRFGDKDNFWSMGDTGACGPCSEIFYDQGEENFNGEEDYMGGDGDRFLEIWNLVFMQYERTADGKLNPLPKPSIDTGMGLERVIAIKEGVFNNFDSSNFKPIIKKIEEISSKNATSENIGSYRVIADHLRACSFMLSQGILFGNEGRPYVLRRILRRAVRHGYLIGFRKPFMAKLLDTLIEIMGGHYTELVENKNFIEEQLTLEEDRFFKTIDLGMSLFNEELEKTKDIFSGVTAFKLYDTYGFPLDLTEDMLRDRGLKVDLAKFDELMNNQKAMAKAAWKGSGDTSNEGDFKQLLEKFGSNEFVGYNNTTYKSKIIALLDEHFKEVKILEKDSTGWVMLDKTPFYATSGGQNGDIGALEDNKHIAIVEETTKFHGLNLSKVKVVNSSLKQGESVDAIVVNRNEVAKHHSATHLLQSALKIVLGDTVSQAGSLNDASRLRFDFTYPKAMTKEQIDEVEDLVNSMIARGISGNVEELPIEQAKKKGAIAMFGEKYGDVVRVVSFEDVSVEFCGGTHVRNTADIGSFYIVKESGVSAGVRRIEAVCGTAAIKYTKDIISKMNEIQAEVKNSDVILGIKKLKEQIKDLKKEIETSQSKTSSPIEETIINDTKVIVSVVENGDLKKIVDDTKNANEKVAIFLLQAKDDKVLIVAGSKNTNIKAGDWIKNIAPIVGGGGGGRPDFAQAGGKDTSKIQEAKTKALDYAKENL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTAS_STAHJ
Sequence: MSLHKKKISLFAFFLLTVFTVTLKTYFSYYVDFSLGVKGLVQNLILLMNPYSLIALILSVFLFFKGKKAYWFIFIGGFLLSFLLYANVVYFRFFSDFLTFSTLNQAGNVESMGGAVGASFKWYDFVYFIDTIVYLFILIFKGSWLDKRVFSKKFVPVVMAASVALFFLNLAFAETDRPELLTRTFDHKYLVKYLGPYNFTVYDGVKTIQNNQQKALASEDDLTKVLNYTKQKNTTPNSEYFGAAKKKNIIKIHLESFQTFLINKKVNGKEVTPFLNKLSTGNEDFRYYPNFFHQTGQGKTSDAEFTMDNSLYGLPQGSAYSLKGDNTYQSLPAILDQKQGYTSDVMHGDYKTFWNRDQVYKHFGIDKFYDATYYDMSDDNIVNLGLKDKPFFKESAEYQSKMKGPFYSHLITLTNHYPFTLSEEDADIDKPNTGDSTVDGYIQTAHYLDQALEEYVTDLKKKGLYDDSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFMDLNRTGFWLKIPGKEGTVDKTYAGQMDVMPTILHLVGIDSKNFLMFGTDMLSKDHNDVIPFRNGDFITKDYKYVNGKAYSNKTNELLETQPKDLDKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFKKIDPSKYEYKTGPKGNQK
What is the function of this protein?
Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate.  Is required for staphylococcal growth and cell division process (By similarity).
What are the official names of this protein?
Lipoteichoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the LTA synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Processed glycerol phosphate lipoteichoic acid synthase]: Secreted.
Protein: MALK_ALIF1
Sequence: MTSVTLRNVCKSYGDVKISKNVDLDINSGEFVVFVGPSGCGKSTLLRCIAGLEDITSGDLYMGDKRMNDVEPSKRGVGMVFQSYALYPHLNLFDNMSFGLKLAKADKNEIKKRVDHAADILQLGHLLERQPKALSGGQRQRVAIGRTLVSQPDVFLLDEPLSNLDAALRVQMRIEIAKLHKKLGCTMIYVTHDQVEAMTMAEKIVVLDGGYVSQVGAPLELYHYPKNRFVAGFIGSPKMNFVSVFIEEVEKSQVKVQFKNGASFWIPVDGSNVKRGERMSLGIRPEHLVPAENGDAVIDGDILVVEKLGYETQIYLTIEDGDADMIYRVPDTALVKAGERFSVGIPAHRCHLFHNDGKACQRLYKEAGV
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Maltose/maltodextrin import ATP-binding protein MalK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LEU1_BUCML
Sequence: DGEQALQASLSVKEKLQIALCLEKIGVDIMEIGFPISSPGDFKSVQIISKNIKNSRICSLARCVEKDIDAAGEAMSASNSFRIHIFLATSTLHMEYKLKKNFHEIIDMAIFAVKRALRYTDDIEFSCEDASRTTIDNLCRIVEKLIYHGVKTINIPDTVGYTVPNELSYIIKNLLERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREDILGVSTNINYKEIYHTSKIISRICNMPIPPNKAIVGSNAFSHSSGIHQDGVLKNRKNYEIIDPSSIGFKKLKLNLTSRSGRAAVKYYMSEMGYKDTDYNIDELYADFLKLADKKGQVFDYDLESLAFISKHPEELEHFCLKFFSVQSISNGLSTASIKLLCGQKLYIESSTTSNGPVDAIYQALNKITNFPIILQKFQLIAKGKGKDALGQVNILIEYKKRKFHGIGLATDFIESSAKAMVNVLNNIWQAEQVNKKLQELKK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: G3P_HUMAN
Sequence: MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
What is the function of this protein?
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:3170585, PubMed:11724794).  Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:3170585, PubMed:11724794).  Modulates the organization and assembly of the cytoskeleton (By similarity).  Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity).  Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094).  Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094).  Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501).  Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity).  Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, Peptidyl-cysteine S-nitrosylase GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Membrane. Cytoplasm, cytoskeleton. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions (PubMed:12829261).
Protein: FUND2_PIG
Sequence: METSSPRAGSQPAPTAARYFASCRAEPLRVSSRDQLAEMAAASQGNFEGNFESLDLAELAKKQPWWRKLFGQESGPSAEKYSVATQLLIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVKSKAEEVVSFVKKNVLVTGGFFGGFLLGMAS
What is the function of this protein?
Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (By similarity).  May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (By similarity).
What are the official names of this protein?
FUN14 domain-containing protein 2, Hepatitis C virus core-binding protein 6.
What is the protein family that this protein belongs to?
Belongs to the FUN14 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Nucleus.
Protein: Y4ZB_SINFN
Sequence: MITTGTPTTRRSAAGTAGADLCPVERCGEPARPGGRLERQQPSPLSPGQRPLADANARRPVAVFAETFGLLAGQLDRQTRREGRAMLRLIDSTPIPLGKLCGWAKSNGRIRGMKMHVVYDPDSDCPRLLDITDANVNDAQIGRTIAIESGATYIFDKGYCHYGWWTAIAEAKAFFVTRPKSNMGLKVVRQRRIKVAEGDGFTVIDDATVRLASKGDSKLPIPLRRLTVKRADGDTITLLTNDRKRPAVAIAALYKGRWQIELLFRWIKQHLKIRSFLGNNDNAVRLQLFAAMIAYALLRIAARLNRITMPILRFTDLVIRCLFERRDIAAIERPPPVNPSHRRPRCSPHQMSFAYV
What are the official names of this protein?
Putative transposase y4zB.
What is the protein family that this protein belongs to?
Belongs to the transposase 11 family.
Protein: DSBD_COLP3
Sequence: MKNLLSLCFLMLAAFTLNPAAAQEKQSIFDVSNSSLFSNDDEFLKVDQAFAFNFYQKNNLLEVSFDIAPEYYLYRHQFKFKGKNTQFTSVLLPDGIDHEDEFFGVQKIFTENLAFTVNLENVSNDASIKITYQGCAEKGLCYPPTSKVIKLSKFILGESTSAPSSDAAQQTNEGEVKKSEQHQLSDMLKQDSLLLTLIAFFVGGLLLSFTPCVFPMYPILTGIIVGQGEGLTTKKAFTLSFFYVQGMAITYTLLGVVVAMAGAKFQAVFQHPIVLIGLSILFIFLALSMFGVFNLALPASWQNKLNNVSNKQKGGSITGVLMMGVISGLVASPCTTAPLTGALLYISQTGDVVLGASALYALSLGMGLPLLILGSSGGKLLPKAGAWMNIIKNIFGLLLLAVPVFLLERFIPEVASQALWALLILVSASYFYVANQNHAAAQNVQQGKGFWYGLRSLVIFLMLFFGANLAYQLIYPSSNNVTNNAQHASFKQVTSLAQLEDEVKKANMQGKTVMVDLYADWCIACKEFEKYTFVDADVQKALSNSVWLQIDMTEFDSTDNAELVQHYTILGLPSILFFDLQGNELTKQRTTGFMKAAEFSAHVKSIFK
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS16_COPPD
Sequence: MAVKMRLLRVGAKGQPSYRVVVADERSPRDGRFIEIVGFYNPRTEPETIQLKEDRVKYWLSVGVKPTDSVRILLRKANMLS
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RL3_SHESW
Sequence: MAIGLIGRKVGMTRIFTEDGVSIPVTVIEVAGNRVTQVKTLETDGYRALQVTTGTKKANRITKPEAGHFAKSGVEAGRGLWEVRLEDGEGEGIEVGAELNVDIFADVAKVDVTGQSKGKGFQGGVKRWNFRTQDMTHGNSLSHRSNGSIGQNQTPGRVFKGKKMSGHMGAERVTTQNLVVVRVDVERNLLLVRGAVPGATNGDLIIKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: DNAA_PROM3
Sequence: MVLTGNELWSKVQQALQHNLSKPTFETWIRPAICSGFRDGELTLIAPNSFASNWLRKNYVQTIEAAAAKIYGQPVRVSVQAQEEDSAERVLPPMASAPVPLPAAEATTASAAPSSGPRRILPGLNLRYVFNRFVVGPNSRMAHAAALAVAEAPGREFNPLFICGGVGLGKTHLMQAIGHYRLEINPEAKVAYVSTETFTNDLIQAIRKDGMQAFRDRYRATDLILVDDIQFIEGKEYTQEEFFHTFNALHEAGRQIVIASDRPPSQIPKLQERLISRFSMGLIADIQSPDLETRMAILQKKAEQERMMLPRDLIQYIAGRFTSNIRELEGALTRAVAFASITGLPMTVESVAPMLDPNGQGVDVTPQQVIDKVSEVFDVTPQDMRSSSRRRAVSHARQVGMYLMRQGTDLSLPRIGETFGGKDHTTVMYAIEQVEKRLSSDPQLASQVRRVRDLLQIDSRRRR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_XANCB
Sequence: MSSVNVDFEQAGELKIGQVGIANLRIRTLDVPRLVREMQDRVTRAPKLFGRAAVILDFGGLAQTPDLATAKALLDGLRSAGVLPVALAYGTSEIDLLSQQLGIPLLAKFRAQYETAAVSPPPPPPPPPARAEPAAPVARPAPGRMQRNAVRSGQQLYAENCDLTVLSTVGAGAEVIADGSIHIYGTLRGRALAGAQGNPDARIFCRDFHAELVAIAGHYKVLDDVPMDLRGKAVQVWLEQDQIKIAALD
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.