PharMolix/UniProtQA huggingface dataset:
Protein: Y2858_ACIBC
Sequence: MLPFKLWVDADALPKILREVILRASDRYQLEVIFVANQNVGITPSVRIKSLQVLSGADQADQEIVNRMSENDIVITQDIPLAAQVIEKGGIAIHPRGEVYTTANVKARLHLRDFMDTLRGAGVQTGGPPPISERDKREFSSALDQTILKQKRKTA
What are the official names of this protein?
UPF0178 protein ACICU_02858.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: NUF2B_XENLA
Sequence: MDKLTFPIFPAADLVNFFRQNILTGTEAKNFNKNDLYPNPKPEMVQKLYMRILQQVFSYGVEQFYMVPMDLDIQYPHLVEGFAPVANILKLMARLLPMCRVYDFHPSDVLNPKGKRTLHLLSGIFNFLQFRTTQREVYMEYCSGYKSALENVRQLQKTNHEAEIKIEKLTTVPPEQQAEFKALSSEIHDLQQIISQEYRAKDVMFQEKIAQRKAEFAEKNKRLNEQKLTIATMKEEQERMKSQIVESPEQRKSKTERMKETVHRLKQARQETSDKCDHYRDRVALAFMWQSDVQGYLKKLQNIDANLEIHRKIHEEIRHIEEQLMNLNLELKSLSNEDAQLKRIILVKKEKLAKVDIKNKKKQEDFNQQKQEILEVCSHIQEKRQVIHGRVAQVLQEIQQTISKKEQLLETTEAGKNKCQEVITDFRAALEKYHDSLQKASERSADRRREKIAELNRRLSRQ
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.  Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.  The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
What are the official names of this protein?
Kinetochore protein Nuf2-B, Cell division cycle-associated protein 1-B.
What is the protein family that this protein belongs to?
Belongs to the NUF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
Protein: RK23A_SORBI
Sequence: MDNGIKYAVFTEKSLRLLGKNQYTFNVESGFTKTEIKHWVELFFGVKVVAVNSHRLPGKGRRMGPILGHTMHYRRMIITLQLGILFHFYPLNSRVF
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23-A, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LOGL1_ORYSJ
Sequence: MGDNSAAAAAVAAPRGRFGRICVFCGSNAGNRAVFGDAALQLGQELVSRGIELVYGGGSVGLMGLIAQTVLDGGCGVLGVIPKALMPTEISGASVGEVKIVSDMHERKAEMARQSDAFIALPGGYGTMEELLEMITWSQLGIHDKPVGLLNVDGYYDPLLALFDKGAAEGFIKADCRQIIVSAPTAHELLRKMEQYTRSHQEVAPRTSWEMSELGYGKTPEES
What is the function of this protein?
Cytokinin-activating enzyme working in the direct activation pathway.  Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms (By similarity).
What are the official names of this protein?
Probable cytokinin riboside 5'-monophosphate phosphoribohydrolase LOGL1, Protein LONELY GUY-like 1.
What is the protein family that this protein belongs to?
Belongs to the LOG family.
Protein: RBS2_PEA
Sequence: MASMISSSAVTTVSRASRGQSAAVAPFGGLKSMTGFPVKKVNTDITSITSNGGRVKCMQVWPPIGKKKFETLSYLPPLTRDQLLKEVEYLLRKGWVPCLEFELEKGFVYREHNKSPGYYDGRYWTMWKLPMFGTTDASQVLKELDEVVAAYPQAFVRIIGFDNVRQVQCISFIAHTPESY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic 2, RuBisCO small subunit 2, PSS15, Ribulose bisphosphate carboxylase small chain 3C, chloroplastic, RuBisCO small subunit 3C.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KDKA_STRM5
Sequence: MVAFDANEALTPCREGRGIGAILFDRERLRQAEADLFSPQHWGSKARPVGEGGRGSAWFIDAPFGASVLRHYLRGGLAAKISHDQYLWRGADRTRSFAEFRLMRALREKKLPVPRPLAAFYMREGLRYRAAILMERIEGVRSLADRALVAGRGAPWEETGRLIARFHRAGLDHADLNAHNILFDGNGHGWLIDFDRGVIRIPATAWRERNLKRLLRSLIKLRGERSVEDVQKDYVRLRRAYDMAWNRGT
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
What are the official names of this protein?
3-deoxy-D-manno-octulosonic acid kinase, Kdo kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. KdkA/RfaP family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL1_THEPX
Sequence: MKRGKKYLESLKLYDKTQQYSSDEAIDIVLKTAKANFDETIDLAVRLGVDPRHADQQVRGTVVLPHGTGKSVKVLVFAKGEKAKEAEAAGADYVGAEELVAKIQNENWFDYDVVVATPDMMGVVGRLGKILGPKGLMPNPKSGTVTFDLEKAIKEIKAGKIEYRVDKAGIIHVPIGKKSFGKEKLLENFRAVMDAIIKSKPAAAKGQYIKSVVLSSTMGPGVKVNPLKIF
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CSPLD_ARALL
Sequence: MASTENPDPETGKSEPIPASATTPPPSAASFLDCRKIDVIIRVLLFSATLTALIVMVTSDQTEKTQLPGVSSPAPVSAEFNDSPAFIFFVVALVVTSFYALMSTLVSISLLLKPEFTARVSVYLASLDMVMLGILASATGTAGGVAYIALKGNKEVGWNKICNVYDKFCRYIATSLALSLFATLLLLVLSICSALSKRTP
What are the official names of this protein?
CASP-like protein 1D2, AlCASPL1D2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRP4_PICTO
Sequence: MEIRQIVYPGEKIDLEGQKPRNGLYEENDEYYSEYFGVVQKSDKFIDIVPFNGPYMPRINDKVIGKVIDVSATMWTVDINSPYFSLMHMNDTPWHVTSGDLRKYLNVGDYIYAKVSILNEIKESWLSLKDVNLRKLEEGSIIYIKAPKVPRVIGKAGNMINMIKSETNTKIIVGQNGLIWIDGEPENVDLAINAIGMVEKEAHTFGLTDRVKAYLDKMKGGNNGRSEVNQ
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Confers strong poly(A) specificity to the exosome.
What are the official names of this protein?
Exosome complex component Rrp4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_RUMCH
Sequence: MRILGIDYGDSRIGVAISDPMGWTAQGLEMIKSKDSLKKAVLRLSEIINEYSVTDIVIGYPINMNGTKGPRTERTEEFIKKISDLGQFNIIKWDERLTTVSAHRTMNELGIKASKKKGIVDTMSAVLILQGYLDRIAGNKKS
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_OSTTA
Sequence: MATARVMVADRARAFGGTTATRARRDDQGRRVTIARGIPSRARVVVARASERAYAELGNVCAVLGSQWGDEGKGKLVDILAREYDVVARCQGGANAGHTIYDDNGKKYALHLVPSGILNENATCVVGNGVVVHLPGMFEEIDKLLQAGVDARGRMIVSDRAHLLFDLHKEIDGLREEELSGNKIGTTKRGIGPAYASKATRNGVRLGDIRDEERFATMLRALAADAAARFEGFQYDVEAEIVRYKEIAERIEPFIADTVEYINEAHDSGKKILVEGANATMLDLDFGTYPFVTSSNPALGGVCNGLGLAPRKFKTIIGVAKAYTTRVGAGPYPTELFGDVADKLRELGYEYGTTTGRPRRIGWLDMVALNYANLINGFTHLNITKLDVLSEMDELKIGVAYKLPNGKTTKSFPADIATLEKVETVYETLPGWKEDISKVRTWDDLPENAKKYVLRVEELAGVECKFIGVGPGRDAMVIKP
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, chloroplastic, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y1365_BRUAB
Sequence: MKPLLSLDRVSVSRDGRNVLDKLSLSLAAGERLALIGDNGVGKTTLLRTIVGLEPASGEITAFGINCRNESDFRKIRAKAAYLFQDPDDQLFCPTVIDDVAFGPLNLGLSRQEAMELSNGLLHDLGLGHLAGRITHHLSGGEKRLVSLAAVLAMQPQVLLLDEPTNALDEKHLERMLAILSAQKIAMIIVSHDWEILERLTDRAVVLRNGKLLPAMLHRHSQWSEQVHLHYVEAEGSAL
What is the function of this protein?
Probably part of an ABC transporter complex.  Responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative ABC transporter ATP-binding protein BruAb1_1365.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TM235_HUMAN
Sequence: MARLGALLLAAALGALLSFALLAAAVASDYWYILEVADAGNGSAWPGRAELLSSHSGLWRICEGQNGCIPLVDPFASESLDVSTSVQHLILLHRAVIVVLPLSLVLLVCGWICGLLSSLAQSVSLLLFTGCYFLLGSVLTLAGVSIYISYSHLAFAETVQQYGPQHMQGVRVSFGWSMALAWGSCALEAFSGTLLLSAAWTLSLSPPICGHLSPQQVGGRGGD
What are the official names of this protein?
Transmembrane protein 235.
What is the protein family that this protein belongs to?
Belongs to the PMP-22/EMP/MP20 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein: ER10A_GIBZE
Sequence: MTVTQLRSAGRLAQLAGHVNGARQFSTRPALRKELQDAYILSAARTPTAKFNGSFLSVSAPKLGAVAIKAALEKSKVPVEKITDVYMGNVLQGSVGQAPARQAVIFAGLPKEIEATTINKVCASGLKAVTLAAQNIQMGLSEAQIAGGMENMSQVPYYVSRASGLPAFGHVKMEDGLIKDGLTDVYDQFHMGNCAENTVKNHNITREQQDEYAIQSYRNAQKAWEDKAFADEIAPVTVKSRKGETVIDTDEGFKDVKFDKIPSLKPAFVRDGSGTVTAANSSTLNDGASALVLGSKAIAQQYGSGSRVLAKICGYADAATAPIDFPVAPAKAVPIALERAGITKDQVAIWEFNEAFASVILANSKILGLEGAKVNPLGGAISLGHALGSSGSRILTTLLHQLKPGEYGVAAICNGGGAATALVVQRVESV
What is the function of this protein?
Mitochondrial acetyl-CoA acetyltransferase that catalyzes both the formation and degradation of acetoacetyl-CoA (By similarity).  Seems not to be involved in ergosterol biosynthesis (By similarity).  Plays an important role in growth, morphogenesis and maintaining mitochondrial function including the response to oxidative stresses (By similarity).
What are the official names of this protein?
Acetyl-CoA acetyltransferase FG05087, mitochondrial, Acetoacetyl-CoA thiolase FG05087.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NUOK2_STRAW
Sequence: MHLAYPAVLSALLFSTGLYGVLARRNAILVLMSVELMLNAVNLNLVAFDVWLSKTARDTLHSGQALTLFTIAIAAAEIGIGLAIVLAVYRNRGTSDIDKLRDTAEGPEPDGPGTDGSAPTAAEKAEATA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K 2, NADH dehydrogenase I subunit K 2, NDH-1 subunit K 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPOZ_SHESR
Sequence: MARVTVEDAVEQIGNRFDMILVAARRARQIAVQGKDPMVEEMNDKPTVIALREIELGLVNAHTLDADERQSVREREAAEIAAVAAIAEGRSL
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: TM168_PONAB
Sequence: MCKSLRYCFSHCLYLAMTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTANSLILVIFILGLFVLGIASILYYYFSMEAASLSLSNLWFGFLLGLLCFLDNSSFKNDVKEESTKYLLLTSIVLRILCSLVERISGYVRHRPTLLTTVEFLELVGFAIASTTMLVEKSLSVILLVVALAMLIIDLRMKSFLAIPNLVIFTVLLFFSSLETPKNPIAFACFFICLITDPFLDIYFSGLSVTERWKPFLYRGRICRRLSVVFAGMIELTFFILSAFKLRDTHLWYFVIPGFSIFGIFWMICHIIFLLTLWGFHTKLNDCHKVYFTHRTDYSSLDRIMASKGMRHFCLISEQLVFFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGNCLGGTSVGYAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSKLKAFLELRTVDGPRHDTYILYYSGHTHGTGEWALAGGDTLRLDTLIEWWREKNGSFCSRLIIVLDSENSTPWVKEVRKINDQYIAVQGAELIKTVDIEEADPPQLGDFTKDWVEYNCNSSNNICWTEKGRTVKAVYGVSKRWSDYTLHLPTGSDVAKHWMLHFPRITYPLVHLANWLCGLNLFWICKTCFRCLKRLKMSWFLPTVLDTGQGFKLVKS
What is the function of this protein?
Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A.  May play a role i the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens.
What are the official names of this protein?
Transmembrane protein 168.
What is the protein family that this protein belongs to?
Belongs to the TMEM168 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CTAA_ANAMM
Sequence: MKAHFGVTVWLGVCCSMTLLMVVIGGITRLTHSGLSITEWQPIVGVVPPIGDEAWLREKEKYAQTPEYRHRAADISLDDFKRIYIIEYIHRLFGRALGAVFCLPIPYFAITKRIDRAMVAKLLIVALLGGMQGAMGWFMVKSGLVDTPRVSHYRLAGHLFLTILLFSILWHSFLRCAGVRSTTTTTNARFFTAAAVVGLTVLQMVLGALVAGLDAGLTYNTFPLMDGAIIPQSLFSAKLWHGGFLHDVTAVQFLHRLVAVLIVVCAAPLPFWLKTRGAWLFLACVALQFLLGVATLVSVVHIFLAAMHQVFGFVTLAAGVHMLCRLRREGSTCISGHAGIS
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ITR1_MOMRE
Sequence: GICPRILMECKRDSDCLAQCVCKRQGYCG
What is the function of this protein?
Inhibits trypsin.
What are the official names of this protein?
Trypsin inhibitor 1, MRTI-I, Trypsin inhibitor I.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I7 (squash-type serine protease inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRHN_PENBI
Sequence: MLSILFDDPARTSSGALLIVGILLLRWALWPAPSSHWPLVNGKRWFEITTTKSKDRFVANGKDILLSSFKRLSKGFRLGTDNGPMIILSPEYVDEFRSEDRLCPVKFQAELAHTHLPGFEILSDKHVPKSVFTDFILRKLTPAIDSTAPASVTRLREALESTWTNSSEWHQIDLHSSVQVLSHTTTSPIFVGPELSSSKAWEELTYRYVGNFPVVACSLRLWPKFSQRFVNMILPSCTSLRKDVNQARQMVNEVLQKRAASQAARISQGLEPEKFSDGLQWWQELSGPPCDPACLQLALIFSAVHSTVDLLSQTILNLAERPELVDELRQEIIAVRESQPWGKAAFYKLGLMDSVLKETQRLKPVSIATEDVTFSDGLVIPKGSLVMMSCHNMREDSVTYPNPLEFDGHRFRKMRESPTNGAMAHLVSSSQHHMGFGIGTHSCPGRFFIAAGLKLTLSQILLNYDLRLSDPSENVTQNQGLFLMPNFKAKVEVRRREPEIEL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of paraherquonin, a meroterpenoid with a unique, highly congested hexacyclic molecular architecture (PubMed:27602587).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase prhL (By similarity).  Synthesis of DMOA is followed by farnesylation by the prenyltransferase prhE, methylesterification by the methyl-transferase prhM, epoxidation of the prenyl chain by the flavin-dependent monooxygenase prhF, and cyclization of the farnesyl moiety by the terpene cyclase prhH, to yield the tetracyclic intermediate, protoaustinoid A (By similarity).  The short chain dehydrogenase prhI then oxidizes the C-3 alcohol group of the terpene cyclase product to transform protoaustinoid A into protoaustinoid B (PubMed:27602587).  The FAD-binding monooxygenase prhJ catalyzes the oxidation of protoaustinoid B into preaustinoid A which is further oxidized into preaustinoid A1 by FAD-binding monooxygenase phrK (PubMed:27602587).  Finally, prhA leads to berkeleydione via the berkeleyone B intermediate (PubMed:27602587, PubMed:29317628).  PrhA is a multifunctional dioxygenase that first desaturates at C5-C6 to form berkeleyone B, followed by rearrangement of the A/B-ring to form the cycloheptadiene moiety in berkeleydione (PubMed:27602587, PubMed:29317628).  Berkeleydione serves as the key intermediate for the biosynthesis of paraherquonin as well as many other meroterpenoids (Probable).  The cytochrome P450 monooxygenases prhB, prhD, and prhN, as well as the isomerase prhC, are probably involved in the late stage of paraherquonin biosynthesis, after the production of berkeleydione (Probable).  Especially prhC might be a multifunctional enzyme that catalyzes the D-ring expansion via intramolecular methoxy rearrangement, as well as the hydrolysis of the expanded D-ring (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase prhN, Paraherquonin biosynthesis cluster protein N.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DXR_MYCMM
Sequence: MTTATDGSADGRLRVLVLGSTGSIGTQALEVIAANPDRFEVVGLAAGGSNLDTLLRQRAETGVTEIAIADERAAQLAGDIAYQGPDAVTRLVEETEADVVLNALVGALGLRPTLAALASGARLALANKESLVAGGPLVLQAAQPGQIVPVDSEHSALAQCLRAGTPDEVAKLVLTASGGPFRGWSAADLQEVTPEQAGAHPTWSMGPMNTLNSASLVNKGLELIETHLLFGIPYERIEVVVHPQSIVHSMVTFVDGSTIAQASPPDMKLPISLALGWPRRVPGAARYCDFSQAQTWEFEPLDDEVFPAVELARHAGETGGCMTAVYNAANEEAAAAFLAGRISFPAIVGTIADVLHAADQWAVSPANVDDVLDAQRWARQRAQRAIAKASPAGACEKVSGLA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: HAPR1_HUMAN
Sequence: MEERKEEGEAEIQEHGPEHWFSKWERQCLAEAEQDEQLPPELQEEAAAAAQPEHKQQKLWHLFQNSATAVAQLYKDRVCQQPGLSLWVPFQNAATAVTNLYKESVDTHQRSFDIGIQIGYQRRNKDVLAWVKKRRRTIRREDLISFLCGKVPPPRNSRAPPRLTVVSPNRATSTETSSSVETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSSGSNASRRRNGLHDVDLNTFISEEMALHLDNGGTRKRTSAQCGDVITDSPTHKRNRMI
What is the function of this protein?
Acts as a central player within a network of stress response pathways promoting cellular adaptability.  The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1.  HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542).  Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365).  May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365).
What are the official names of this protein?
HUWE1-associated protein modifying stress responses 1, Telomere attrition and p53 response 1 protein.
What is the protein family that this protein belongs to?
Belongs to the HAPSTR1 family.
Protein: MURA_VIBVY
Sequence: MEKFRVIGSTQPLMGEVTISGAKNAALPILFASILAEEPVEVANVPHLRDIDTTMELLKRLGAKVERNGSVHVDPSSIDEYCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHITGLEQLGATITLEDGYVKAHVDGRLQGAHIVMDKVSVGATITIMCAATLAEGTTVLDNAAREPEIVDTAKFLNTLGAKISGAGTDTITIEGVERLGGGKHAVVADRIETGTFLVAAAVSGGKVVCHNTQAHLLEAVLAKLEEAGALVETGEDWISVDMTGRELKAVNIRTAPHPGFPTDMQAQFTLLNMMAKGGGVITETIFENRFMHVPELKRMGAKAEIEGNTVICGDVERLSAAQVMATDLRASASLVIAGCIAKGETIVDRIYHIDRGYDKIENKLNALGAKIERFRESN
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PHYME
Sequence: MRWNKKSLFAVLNNHLIDYPTPINLNYFFGFGSLAGIMLVVQILTGIFLAMHYTPHIDLAFNSVEHIMRDVNNGWLMRYTHANGASFFFIVVYVHIFRGLYYGSYITPREALWCSGVIIFILMMATAFMGYVLPWGQMSFWGATVITNLFSAIPLIGKDIVDWLWGGFAVDNPTLNRFFSLHFTFPFVIVGAVLIHLILLHEVGSNNPLGITLKTENIPFYPYFYTKDLFGLMVLFLVFFIFIFYYPNTLGHPDNYIEANPMKTPLHIVPEWYFLPFYAILRSIPNKIGGVIAMFGSLIVLLTIPFTNSSEIRSTAFRPIFKVCYWLLVVAFLLLGWVGQCPVEYPYTEIGIISMIYYFFFFIIIIPFLGKFETYLVRYNTNK
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UPPP_KLEP3
Sequence: MSDIHSLLVAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTANTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGRPPEHEGKGSGRLSLIHILLGMIPAVVLGLIFHDTIKSLFNPVNVMYALIVGGVLLIAAEVLKPKQPRAVGIDDMTYRQAFVIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATVLDVYKSIGFLNMGDVPMFAVGFVMAFIVALIAIKTFLQLIKRISFIPFAIYRFIVAAAVYVVFF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PNP_STAS1
Sequence: MSQEKKVFKTEWANRSLTIETGQLAKQANGAVLVRYGDTVVLSTAVASKEPRDGDFFPLMVNYEEKMYAAGKIPGGFKKREGRPSDEATLTARLIDRPIRPLFPKGYKYDVQIMNTVLSADPDCSPEMAAMIGSSMALSVSDIPFQGPIAGVKVGYIDGEYVINPTVAQKEVSRLDLEVAGHKDAVNMVEAGASEITESEMLEAIFFGHSEIQRLVNFQQEIVDHIQPKKKAFVPVEKDEVLVEKVKQLTQENGLKDAVLTFDKQQRDINLDALKEKVAAEFIDEEDADNEVLIKEVNSILNDLVKEEVRRLIAEEKIRPDGRKTDEIRPLESEVGVLPRAHGSGLFTRGQTQALSVLTLGSMSEYQILDGLGEEEQKRFMHHYNFPNYSVGETGPVRSPGRREIGHGALGERALSHIIPDLKDFPYTVRIVSEVLESNGSSSQASICGSTLALMDAGVPIKAPVAGIAMGLVTRDDSYTILTDIQGMEDALGDMDFKVAGTAEGITAIQMDIKIDGLTKEIIKEALDQAREGRLAILDHMLQTIDTSRSELSAFAPKVVTMTIKPEKIRDVIGPGGKKINEIIDETGVKLDIEQDGTIFIGAVDKDAIARARSIIEDITREAEVGQVYEGKVKRIEKYGAFVELFPGKDALVHISQIANERIDKVEDVLKVGDIFKIKVTEIDKQGRVNASHKALL
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.