Protein: IMQB_ASPFN
Sequence: MLSPAVCYHTDEGKNGYTFPNLETPKNGVVQTPVQYLIQTAPLHDFCSHQMVDLRTLLQCAWSRVIAQLDSTTDLKADAIYGTKSKSLLEGFISEVKKSQQSTQLENERILTEKLLLPLNPRGTSSLSWLQNDLLCATGGEYGEQSTGGFELAQCGSWIAISASFNPLIVSSRWVNDYIEVFRSFLVALVVGDDELSAPENYLTPEDCARIRNWNSAVPPEINASILDVFSEQVKAHPGSTAVSGWDASLTYQELEDCADQLAYQLQSRGVGPGMLIPLCFEKSAWTVVAIIAVISTGAAFVLLDASQPEARLRSIVMQTRATLMITSSQKKDLGRRLVPEVVSVQPTKSTKNSERSRALRPVIKPDSLLYVVFTSGSTGQPKGAMISHSNFVSAVHYRRSELYNVTPRVLDFASYSFDISIESTLAPLLLGGCVCVPSDASREADPSDAIKAFNVNQVMLTPSVARLVEPENVPSLRLLHLGGEQISRFDIERWPSTVKLINGYGPAECTVVSTANTVSPSSPEAHTIGRGLGAVTWVVDPADTGRLVPVGAVGELVIEGPLVGSGYLHDEGRTLAAFIVDPPWLRAFGRRGRLYRTGDLVSYNSNGTLTFIGRKDTQVKVNGQRVELGEIEHNLQQEIYNQGNCVVDVVVDLISVNSNSGKQSILLAFLGLERAAQERFAASGTPSVQELTSAMWEILEPINLFKVLPRYMVPSIYIPLWRMPLLPSGKINRLKLRSMGESLSVDDLAAFRKPQVATVDTQGRITPQEKLLQSLWGQIFPHCAGSIQPDDNFFSLGGDSLTAMKLVGLIRKHGIENKHSETIRIADILQWPRLADMARCITRVDDKQGDVQDALFDLLPDHIAPSNARQIAAPQCDVQPEQIVDIYPCTPLQEGLMALSAERSGAYIAQNIFELSDRTNIDTLRMAWTHIVMSSVIFRTRIVQLDSQTLAQAVVTVPIEWECYDGKLNDFVAIDRHRPMGIGKALMRLTVVTERSEESLLKCFLVWTAHHAVFDDWILNLITSLVGKMYHGRPPSSFHLTPYKRFIRHLQELNRESFSNYWRQELEGTNAAIFPHLPSAVDKPVADATANFAFSLNDSKLNVHASLPTILRAAWSILVSRHTQTDDVIFGETLTGRNAPVAGVEEMDGPTLTTIPRRVKVQNEMRVAEFLEEIRRHEINSIPYEGFGLQNIQKLSDDARTACQFATLLVIQRDPEVSFDSPMINVTEKVLHEDCGEDGKPYASFFTTYPLMVTISIKDNQINIYASFDSRIIERSQMQVLMHQLEVITRQVIQEPHEVVGGINCLTRKELHQIWSWNRLPWVPVSGSVHDSIAEVSNTRPTAPAVCAWDGSLTYGELDNLSTRLGSYLFKVGVEAESLVPLCFEKSVWTIVSMLAVIKAGGAFVLLDPTQPKQRLGEIIVRAKANYVLTSPLQYGMVSDLASEFNLTIVLVSKSPLDALTDDATVTDRMPQHLDSDRPLFVTFTSGSTGKPKGVISTHGSYLSGVNYRRSILQLPNLDMRVFDFASYSFDVSTDVILSTLLTGGCVCVPSDFDRKNNIPGAINALRVNAADLTPSVSRLLSPESVPGLKVLKLGGEANTAADHALWLGKTTLVNIYGPSECLVVTAKTVLPGIDPCNIGRGLGANTWVADPTNHDRLAPIGSIGELLVEGPILGRGYLDDQKQTDAVFIHNPTWLVKGLPGFQPGREGRVYKTGDLVRYNPDGTLHYIGRKDRQLKVRGQRVEPAEIEGAIKRHMQSKLGMTIDVVADLVTSNRDQRKRLIAFLGLNQVLESRGYSEKDHLGDTVLRDIMWEVTAGLEVLLSQTLPPYMVPSVYVPLRHIPLLPSGKTDRRKLQSAAASLSPEDLSFFRERPKAQNRAIATPKEEKLQKIWADALGVKSIQAEDNFFTIGGDSIAAMRLVGLARDQGLLLSVADIFQRPRLYEMAEKAAETGTELLDIPAFSLLPGANPYVIDEREVAAAQCGCSIELIEDIYPCTPLQEGLMALSTKTPGAYISQNVFQMGNATNTDLMKEAWDYVVRSNPIMRTRVILSARQDLVQVTVQEGIHWASHDSLDCYLKYDRNTSMGLGMPLTRLAWVDDEMTKRSFLVWTAHHAIFDGWVLSLVMENVIRVYHGKSLHVGPPFKAFIKYLKELERAQMDTFWQDEFSGITATPFPALPSSTYQPKADVETKLEMSFTWSTTSNVTSSTFLRLAWAVLVARLTASSDVIFGETLNGRNAPIPGIERMIGPTLTTLPRRIVLEDGLPVADLLHRLKDHEIAMMPFEHVGLQHLQELSADCQAACKFQTLFVVQRGMDHDMSEMSLTISGDVSNFNSYALMLTCAPESDKILFHASHDSNVISPEKMQDVLNQLQNVVMQLSKKMDRPLREINCLSEIDTQQIWKWNHQLPESISIPVHEIIAQQAREHPATEAVCAWDGTFTYRELDTLAGQLAYHLKELGAVSTPGYHIPLCFEKSAWTVISILAVMKAGGSFVLLDVSQPQDRLQHIVSHIKANYILSSPRQSDLASSLAANVVVVSSDFVRSLRQLHTPGPLNPNSALYVVFTSGSTGKPKGVIITHLNFASGVHYRQNVMHMPGFRLLDFPSYSFDASVESNLVPLMIGGCVCIASDELCQNNLSAAISSTNANAVMLTPSSATLISPENAHSLKQLHLGGEKLTAANIETWADKLKLVVGYGPAECAVTTTGRIVKGMVPQKENIGPAFGAVTWLVDPASHDRLVPLGTIGELLIEGPIVGQGYVNDPERTAAAFIENPPWLLAGGGMFAGRQGRLYKTGDLARYDSDGTLIFIGRKDTQVKIRGQRVELQEIEHHVYQYLRDLTGLGLSIVADLISTCSDIANPTLVVFIELEAVMTQKGYLPDPGPAVLYNEMKSMVPGLDEALRNALPRYMIPSAYVPRWKLPMMPSGKLNRKQLRSDAESLTAEQWNHFRSLISAVSPAARGREVATNDEAAVQRLWADILRIAEKQIKADDSFFTLGGNSITAMKLVELARRRGILFNVADVFAHPVLSDLASRIGRVETTPLNQDDLAYAPLQRLMSSNPTLIQGQSSNIPLVMIHDGGGTTYAYHRMGPVNRPLYGIHFPGYASGTAWKGGIKSLGRHYADLIQKSLLSGPIILGGWSSGGLISLEVALCLKSGPFEVKGVIMVDSVFPAPSLVDETFLAPSSSETNDTAMAADGTLAKMNMFQFNSMLKEYSPPRFEDLFQDLDASKAGLCHEQRSNVNPITEDTHHAERFPVHLLRASSTKASIGELDENMKSFLDATLGWEHYRPRLVSEVDLIDAEHYSLFSANTVAETTRHIRDFCDRITKSRKV
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination (PubMed:29182847).  ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors (PubMed:29182847).  N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline (PubMed:29182847).  Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation (PubMed:29182847).  The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH (PubMed:29182847).  Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins (PubMed:29182847).
What are the official names of this protein?
Nonribosomal peptide synthetase imqB, NRPS imqB, Imizoquin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.