PharMolix/UniProtQA huggingface dataset:
Protein: ORSE_EMENI
Sequence: MATNQAAWLTKAGNDLEVGDAPVPTAGPGEIVVKNAAVAINPLDTHMQDVGVFVQQWPTIFGCDVAGTVHETGPDVERFKKGDRVIGHAINLVTGRPQDGAYALYTVVPANKAAILPDAISFTDGVVAPFAVEAAVCVLSLKEPGVAMPGVSTPALALPYPSLDDPVKPLGKVLVIWGGSSSVGSMTTQIATAAGIQVIAISGAHNFELSKRCGATEVFDHKDPEVVDKVVAAVQKSGQEFVGIFDAVATPDTYTSDLVILEKLGGGHLAAVHPPPAEVPSNVKAGMIFAVNDIATPVWNDFVTPALESGKIQCLPPPTIVGKGLEAINEGLKRCKAGVSATKLVVEL
What is the function of this protein?
Dehydrogenase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B (PubMed:19666480, PubMed:20174687).  The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:19666480, PubMed:20174687).  Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B (PubMed:20174687).  The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B (PubMed:20174687).
What are the official names of this protein?
Dehydrogenase orsE, Enoyl reductase orsE, Orsellinic acid/F9775 biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: EFGM_DANRE
Sequence: MRLLRAASSLARLHRPGHSTLQQVLISCRSCSNGITPNERIRNIGISAHIDSGKTTLTERVLYYTGRIAEMHEVRGKDGVGAIMDSMELERQRGITIQSAATYTMWKNHNINIIDTPGHVDFTIEVERSLRVLDGAVLVLCAVGGVQCQTVTVNRQMKRYSVPFLTFINKLDRLGANPNRALQQLRTKLNQNAAFVNIPIGLEGNLRGIIDLIEERSIVFDGPFGESVRYEDIPPEMRSEAADRRQELVECVANADETLGEMFLEERVPTVLDLKAAVRRATVKRSFSPVLVGSALKNKGVQPLLDAVLEYLPNPTEVQNYAILNEEGESEGSKILMDSTRDDTQPFVGLAFKLEAGRFGQLTYVRVYQGCLRKTDYIHNSRTGRRVRVQRLVRLHADQMEDVEVAYAGDICALFGIDCASGDTFTARNNANLSMESIHVPEPVISMAIRPSNKNDTDKLSKGISRFTREDPTFRVHFDTESKETIISGMGELHLEIYSQRMEREYSCPCVMGKPKVAFRETLTSAVPFEYTHKKQSGGSGQYGKVIGVLEPLDSENYTKVEFSDETVGTNIPKQFVPAVEKGFRDACEKGPLIGHKISGVRFVLEDGAHHMVDSNEISFIRAGEGAVKQALEKATVVILEPVMSVEIVAPNEFQGAVIAGVNRRHGVISGQDGADGYFTLYADIPLNDMFGYATELRSCTEGKGEYTMEYSRYQPCAASVQEDLVNKHLEATGQLPAKKSKWKN
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.  Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL10_HELPG
Sequence: MQKQHQRQHKVELVANLKSQFVDAKALLICDYKGLSVKKLEALRNKARNQGIKVQVIKNTLAHIAMKEAGYSDLDLKETNVFLWGGDQIALSKLVFDFQKEHKDHFVLKAGLFDKESVSVAHVEAVSKLPSKEELMGMLLSVWTAPARYFVTGLDNLRKAKEEN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ODBB_BACSU
Sequence: MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGLYEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIRYRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKAAVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFALQAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAIISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF
What is the function of this protein?
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
2-oxoisovalerate dehydrogenase subunit beta, Branched-chain alpha-keto acid dehydrogenase E1 component beta chain, BCKDH E1-beta.
Protein: PROB_SALPK
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHIGQMLLTRADMEDRERFLNARDTLRALLDNHIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQQGLFTADPRSNPQAELIKDVYGVDDALRSVAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIASGSKPGVIGDVMEGISVGTRFHAQASPLENRKRWIFGAPPAGEITVDEGATAAMLERGSSLLPKGIKSVTGNFSRGEVIRICNLQGRDIAHGVSRYNSDALRRIAGHHSQQIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_PAPHA
Sequence: MAHPVQLGLQDATSPVMEELITFHDQALMAMFLISFLILYALSSTLTTKLTNTNITDAQEMETIWTILPAVILILIALPSLRILYMTDEINNPSFTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLNPGDLRLLEVDNRVVLPIEAPVRMMITSQDVLHSWTIPTLGLKTDAVPGRLNQTVFTATRPGVYYGQCSEICGANHSFMPIVAELIPLKIFEMGPVFTL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y027_MYCA9
Sequence: MTRTDGDQWDIVSSVGFTALMVSSFRALETTRTEPLIRDEYARAFVEASGEPRLTEALAAGTPESEWDTATVYLVNHLAVRTKYFDEFFAAATGSGIQQVVILAAGLDSRVYRLPWPDGTVVYELDQPKVLEFKDHVLREEHAVPLAERREVAVDLRDDWIAALRTAGFDATKPTAWLAEGLLAYLPGAAQDALFENITAHSAPGSFLATEWRRRQATAGQWQDAVNKLKPEFIKDISIGSLIYDDERQDPIEWLREHGWQVDTANRLEQAAAYGRPAPSEHSDVTSLWSDAYFITATR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase MAB_0027c.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: SAL_SILAS
Sequence: MMLILKLSLLSLLIATPGLLVSGANMITCYGDVQKLHCETGLIIVKSSLYGRTDSTTCSTNRPPAQVAVTTCSLPITTIGDRCNGLPDCELKTDLLGNTDPCQGTYKYYNTSFDCINGNYAVICEHGYSTLDCGNDAILIVNANYGRASSQICSNGLPNGLTQNTNCYAANTLTTVAGLCNGKKSCTVEALNTIFSDPCSGTVKYLTVTYICTKEMVVCEGGSASINCGAQTIKTIWANYGRTDSTVCSTGRPGSQLLNTNCYTSDTLNKVAAGCDHLSTCTIPANNNFFGDPCPNTYKYLRIVYACV
What is the function of this protein?
Lectin that binds L-rhamnose.  Binds also monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose.
What are the official names of this protein?
Rhamnose-binding lectin, RBL, Roe lectin, SAL.
What are the subcellular locations of this protein?
Secreted.
Protein: PRPD_MYCTE
Sequence: MVRIMLMHAVRAWRSADDFPCTEHMAYKIAQVAADPVDVDPEVADMVCNRIIDNAAVSAASMVRRPVTVARHQALAHPVRHGAKVFGVEGSYSADWAAWANGVAARELDFHDTFLAADYSHPADNIPPLVAVAQQLGVCGAELIRGLVTAYEIHIDLTRGICLHEHKIDHVAHLGPAVAAGIGTMLRLDQETIYHAIGQALHLTTSTRQSRKGAISSWKAFAPAHAGKVGIEAVDRAMRGEGSPAPIWEGEDGVIAWLLAGPEHTYRVPLPAPGEPKRAILDSYTKQHSAEYQSQAPIDLACRLRERIGDLDQIASIVLHTSHHTHVVIGTGSGDPQKFDPDASRETLDHSLPYIFAVALQDGCWHHERSYAPERARRSDTVALWHKISTVEDPEWTRRYHCADPAKKAFGARAEVTLHSGEVIVDELAVADAHPLGTRPFERKQYVEKFTELADGVVEPVEQQRFLAVVESLADLESGAVGGLNVLVDPRVLDKAPVIPPGIFR
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate (PubMed:16689789).  Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity).
What are the official names of this protein?
2-methylcitrate dehydratase, 2-MC dehydratase, Aconitate hydratase, ACN, Aconitase.
What is the protein family that this protein belongs to?
Belongs to the PrpD family.
Protein: ENG1_SCHPO
Sequence: MSSYLRSFIFGLLTISLAQCSPILKDTKDTKFSTGSNISLKKRDTNVFDSVVDTINPASYFGTVSHPVTPAGVSTDSLSSPIETNKFFDNNLLGSRTNFMYADPFRYWWQSSDTMGGICIAHTDDNQRVMDTDDTIPSYYYEPIGICSLGFGASGITSNTDPIVDEIDQMSARFTFSWDSSSMQLTLTEGMAVTTAVYTNAIPQIFSSTLYINDFVEVPGTSAVQKYRVTMSDNHVWLIYIYGDSLTLTESTSQMLVGSNTFNGYIQIAKIPLGDGTAEALYDTYAGVYITGISISGYVEDAVGYYSFDFTTAGDTSVEPLFFLLPHQVDTAVSGTKVTSIVLASLVSGDMNAAAGNSITFAEAIPQDIGFLPWSPTGGQIGYSEEALEIIAEVAGTELGEDFSANSNLNSMYYSGKVLAKYAMLCVTINDILGDETSSEQCIQKLEAAFARFVDNQQIYPLTYDNTWKGVVSVAGLSGDSLADFGNSYYNDHHFHYGYFVFTAAVIGHIDPDWINTGNNKEWVNFLVRDVANPSSNDPYFPKHRMIDIYHGHGWASGLFESNDGKDEESTSEDYNFFFGMKLWGQVIGDSDMEDRANIILGIERNALNKYMLYADGNVQPTSMQPNYVAGITFMNKITHTTYFGTNIEYIQGIHMLPITPISAFIRGPSFVLAEWNALLASVIDYVDSGWRSLLYANLAIAEPEESYEYFSSSDFNTDYLDDGASRAWYLAYAAGLWANDAVYYPVSSSSTTTTSTSTGSVTTTSTTATASCTLPISYTSTPTTTSISGTCNGATFDASLYVCDGTVLCPIVNGVSYQNCNGACYNPSQYGCDNGALGPVQSSSTTSSITPTPTTTSSITPTPTTTSTTTTAQSTGMQLCGSNYYDASSYYCDNDQLCPIIDGVDYLSCNGACYNPSQYVCSDGSLSPNTVTTTKATTTFTPTPTTTTTPTPTTTSATSTNVIAQCGSAWYDSQSYICYGNILCPIINGSPLLACGNACYDSSIYGCSNGALVAA
What is the function of this protein?
Cleaves internal linkages in 1,3-beta-glucan (Probable).  Has a role in cell separation where it is required for the degradation of the primary septum after completion of cytokinesis (PubMed:12665550, PubMed:18466295).
What are the official names of this protein?
Primary septum glucan endo-1,3-beta-D-glucosidase, Glucan endo-1,3-beta-D-glucosidase 1, Endo-1,3-beta-glucanase 1, Laminarinase-1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 81 family.
What are the subcellular locations of this protein?
Cell septum. Note=Localized in a ring-like structure around the septum.
Protein: QUEA_STAA8
Sequence: MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLNDTRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECIKEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTAGLHFTDELLIEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLNDTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLPKSTLVMLVSAFSSRENVLNAYKTAVNLEYRFFSFGDAMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KATG_HALHL
Sequence: MADQQKAGGCPVMHGAMTQVGESNLDMWPNALNLDILHQHDRKPDPMGEGFNYREEVKKLDLDAVKQDLHQLMTDSQAWWPADWGHYGGLMIRMAWHAAGTYRVADGRGGGGTGNQRFAPINSWPDNVNLDKARRLLWPIKKKYGNRLSWADLIILAGNVAYESMGLKTFGFSLGREDIWHPEKDIYWGSEKEWLAPSDSEDSRYGEDRASLENPLAAVMMGLIYVNPEGVDGNPDPLRTAEDVRITFERMAMNDEETVALTAGGHTVGKCHGNGDVENLGPDPESADVEEQGLGWNNKVTRGVGRDTVSSGIEGAWTTYPTRWDNGYFHLLLNYEWELTKSPAGAWQWEPVDIKEEDKPVDVEDPSIRLNPIMTDADMAMKMDPAYRKISERFYNDPAYFDEVFARAWFKLTHRDLGPRTRYIGPEAPQEDLIWQDPVPAGRTDYDVEALKAKIADSGLSIGEMVSTAWDSARTFRGSDNRGGANGARIRLAPQKDWEGNEPERLSKVLGVLEGIAADAGASLADTIVLAGNVGIEQAARAAGHDITVPFAPGRGDASQEMTDVDSFQYLEPLADGYRNWVKKEYAVQPEEMMLDRTQLMGLTAPEMTVLVGGMRVLGTNHGGTKHGVLTDREGQLTNDFFVNLTDMAYTWKPVGSNRYEIRQRSSDAVKWTATRVDLVFGSNSILRSYAEVYAQDDNREKFVHDFVAAWTKVMNADRFDLVA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: SUB6_ARTGP
Sequence: MGFITKAIPIVLAALSTVDGAKILEAGPHAETIPNKYIVVMKQDVSHEAFNAHATWVGNNFSRRPMRRGGSFKPMAGMQHKFSLGGTFKAYTGEFDEAMIKDISNHDDVDFIERDTVVKATAITQQDNVPSWGLARVGSKEAGGSTYYYDDTAGKGVTAYIIDTGIDIHHGDFGGRAKWGKNFVDKMDEDCNGHGSHVAGTVGGTKFGVAKGVNLVAVKVLDCEGSGSNSGVIMGMEWAMKEASGGGNSTAKAAGKSVMNMSLGGPRSEASNKAAKAIADAGIFMAVAAGNDNMDAQHSSPASEPSICTVAASSEDDSKADFSNYGAVVDIYAPGNEITSVKPGNGTDTLSGTSMASPHVCGLGAYLIGLGKEGGPGLCDTIKEMATDAIKNPGEGTTGKLIYNGSGK
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUCL_RAT
Sequence: MVKLAKAGKTHGESKKMAPPPKEVEEDSEDEEMSEDEDDSSGEEEVVIPQKKGKKATTTPAKKVVVSQTKKAAVPTPAKKAAVTPGKKAAATPAKKAVTPAKVVPTPGKKGAAQAKALVPTPGKKGAVTPAKGAKNGKNAKKEDSDEDEDEEDEDDSDEDEDEEDEFEPPVVKGVKPAKAAPAAPASEDEDEEDDDDEDDDDDDEEEEEEDDSEEEVMEITPAKGKKTPAKVVPVKAKSVAEEEEDDEDDEDEEEDEDEEDEEDDEDEDEEEEEEPVKAAPGKRKKEMTKQKEAPEAKKQKIEGSEPTTPFNLFIGNLNPNKSVAELKVAISELFAKNDLAAVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDAVEIRLVSQDGRSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNPHGKSKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDFKPQGKKTKFE
What is the function of this protein?
Nucleolin is the major nucleolar protein of growing eukaryotic cells.  It is found associated with intranucleolar chromatin and pre-ribosomal particles.  It induces chromatin decondensation by binding to histone H1.  It is thought to play a role in pre-rRNA transcription and ribosome assembly.  May play a role in the process of transcriptional elongation.  Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
What are the official names of this protein?
Nucleolin, Protein C23.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: PETL_SACSP
Sequence: MLTITSYFGFLLAALTITPALFIGLNKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DSUP_RAMVA
Sequence: MASTHQSSTEPSSTGKSEETKKDASQGSGQDSKNVTVTKGTGSSATSAAIVKTGGSQGKDSSTTAGSSSTQGQKFSTTPTDPKTFSSDQKEKSKSPAKEVPSGGDSKSQGDTKSQSDAKSSGQSQGQSKDSGKSSSDSSKSHSVIGAVKDVVAGAKDVAGKAVEDAPSIMHTAVDAVKNAATTVKDVASSAASTVAEKVVDAYHSVVGDKTDDKKEGEHSGDKKDDSKAGSGSGQGGDNKKSEGETSGQAESSSGNEGAAPAKGRGRGRPPAAAKGVAKGAAKGAAASKGAKSGAESSKGGEQSSGDIEMADASSKGGSDQRDSAATVGEGGASGSEGGAKKGRGRGAGKKADAGDTSAEPPRRSSRLTSSGTGAGSAPAAAKGGAKRAASSSSTPSNAKKQATGGAGKAAATKATAAKSAASKAPQNGAGAKKKGGKAGGRKRK
What is the function of this protein?
Unique chromatin-associating protein that contributes to the organism's exceptional tolerance to harsh environmental stresses (PubMed:27649274, PubMed:31571581).  Binds with a higher affinity to nucleosomes than to free DNA (PubMed:31571581).  Protects chromatin from damage caused by hydroxyl radical-mediated cleavage induced by X-rays or treatment with hydrogen peroxide (PubMed:27649274, PubMed:31571581).  Suppresses X-ray-induced DNA damage that includes single-strand breaks (SSBs) as well as more hazardous double-strand breaks (DSBs), and improves radiotolerance (PubMed:27649274).  Shields also DNA against reactive oxygen species (ROS) (PubMed:27649274).
What are the official names of this protein?
Damage suppressor protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS15_FLAPJ
Sequence: MYLTKEIKEEIFAKHGEKTNTGKAEAQIALFTFRISHLTEHLKKNRHDYNTERSLVLLVGKRRSLLDYLKKKEINRYREIIKELGIRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: FYN_MOUSE
Sequence: MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL
What is the function of this protein?
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance.  Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain.  Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions.  Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin).  Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT.  Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage.  Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6.  Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein.  Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation.  Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation.  Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts.  CSK maintains LCK and FYN in an inactive form.  Promotes CD28-induced phosphorylation of VAV1.  In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (PubMed:12681493).
What are the official names of this protein?
Tyrosine-protein kinase Fyn, Proto-oncogene c-Fyn, p59-Fyn.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking (By similarity).
Protein: SPXM2_ARATH
Sequence: MVAFGKKLKERSIEEWQEYYINYKLMKKKVKQYGPQIEVGSLDRRHVLKDFSRMLDHQIEKIALFMLEQQGLLSSRLQKLREWHDTLQDEPDLSQIAKLREAYRAVGQDLLKLLFFIDMNAIGIRKILKKFDKRFGYRFTNYYVKTRADHPYSQLQQVFRHVGLGAVVGAISRNLHELQNNEGSYLSIYDQPVLPLQDPVVDSIKNAVDRLTHSTNFLNFMAQHALIMQDDEDLLMLPPDEQAEKEEGRYHFMSLLLNLANTFLYMVNTYIIVPTADDYSMSLGAAATVCGVVIGAMAVAQLFSSVYFSAWSNKSYFKPLIFSSIVLFFGNLLYALAYDFNSLALLLIGRLFCGFGSARAVNRRYISDCVPLKIRMQASAGFVSASALGMACGPALAGLLQTDFKIKNVTFNQDTLPGWVMAVAWLLYLVWLAISFREPAREPEEIHTSQESTSEQIFCGEADQDGNIEKGLKKPLLLASEETEHDEEDDGDGSEESSDDSRKPANSFVAAYKLLTPSVKVQLLIYFMLKYAMEILLSESSVVTTYYFGWSMSSVSIFLFCLGLTVLPVNLVVGSYISNMFEDRQILLASEIMVCIGIVLSFHVVIPYTVPQYVISGFIMFVSAEVLEGVNLSLLSRVMSSRLSRGTYNGGLLSTEAGTIARVIADATITLAGFLGQSMLLNVTLLPSLIICVLSILATCYTYNSLY
What are the official names of this protein?
SPX domain-containing membrane protein At4g11810.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NCAP_I78A6
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELILYDKEEIRRIWRQANNGDDATRGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFSARSALILRGSVAHKSCLPACVYGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGTKVSPRGKLSTRGVQIASNENMDTMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFDKSTVMAAFTGNTEGRTSDMRAEIIRMMEDAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.