PharMolix/UniProtQA huggingface dataset:
Protein: ATPA_OENEH
Sequence: MATIRADEISNIIRERIEQYNREVKIVNTGTVLQVGDGIARIYGLDEVMAGELVEFEEGTIGIALNLESKNVGVVLMGDGLLIQEGSSVKATGRIAQIPVSEAYLGRVINALAKPIDGRGEISSSESRLIESPAPGIISRRSVYEPLQTGLIAIDAMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGNNVICVYVAIGQKASSVAQVVNALQERGAMEYTIVVAEAADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDPSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSRLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFSSDLDKATQNQLARGQRLRELLKQSQAKPLTVAEQILTIYTGTNGYLDSFEIAQVRKFLDELRDYVKTRKPQFEEIISSTKIFTEEAQALLKDAIQEQKELFLVQE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RNAS6_MOUSE
Sequence: MVVDLPRYLPLLLLLELWEPMYLLCSQPKGLSRAHWFEIQHIQTSRQPCNTAMRGVNNYTQHCKQINTFLHESFQNVAATCSLHNITCKNGRKNCHESAEPVKMTDCSHTGGAYPNCRYSSDKQYKFFIVACEHPKKEDPPYQLVPVHLDKIV
What is the function of this protein?
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:15693621).  Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P. aeruginosa, A. baumanii, M. luteus, S. aureus, E. faecalis, E. faecium, S. saprophyticus and E. coli (PubMed:15693621, PubMed:25075772).  Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity).  Probably contributes to urinary tract sterility (PubMed:25075772).  Bactericidal activity is independent of RNase activity (By similarity).
What are the official names of this protein?
Ribonuclease K6, RNase K6.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Lysosome. Cytoplasmic granule.
Protein: MTEF1_PONAB
Sequence: MQSLSLGQTSISKGLNYLTIMAPGNLWHMRNNFLFGSRCWMTRFSAENIFKSVSFRLFGVKCHNTDSEPLKNEDLLKNLLTMGVDIDMARKRQPGVFHRMITNEQDLKMFLLSKGASKEVIASIISRYPRAITRTPENLSKRWDLWRKIVTSDLEIVNILERSPESFFRSNNNLNLENNIKFLYSVGLTRKCLCRLLTNAPRTFSNSLDLNKQMVEFLQAAGLSLGHNDPADFVRKIILKTLYLIQSTKRVKANIEFLRSTFNLNSEELLVLICGPGAEILDLSNDYARRSYANIKEKLFSLGCTEEEVQKFVLSYPDVIFLAEKKFNDKIDCLMEENISISQIIENPRVLDSSISTLKSRIKELVNAGCNLSTLNITLLSWSKKRYEAKLKKLSRFA
What is the function of this protein?
Transcription termination factor.  Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination.  Binds DNA along the major grove and promotes DNA bending and partial unwinding.  Promotes base flipping.  Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand (By similarity).
What are the official names of this protein?
Transcription termination factor 1, mitochondrial, Mitochondrial transcription termination factor 1, mTERF.
What is the protein family that this protein belongs to?
Belongs to the mTERF family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: VATA_STRPI
Sequence: MTQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRRDQASIQVYEETSGLGPGEPVVTTGEPLSVELGPGLISQMFDGIQRPLDRFKLATHNDFLVRGVEVPSLDRDIKWHFDSTISIGQKVSTGDILGTVKETEVVNHKIMVPYGISGEVVSIASGDFTIDEVVYEIKKLDGSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVIDTFFPVTKGGAAAVPGPFGAGKTVVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMQRTVLIANTSNMPVAAREASIYTGITMAEYFRDMGYSVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRIAEYYERAGRSQALGLPEREGTITAIGAVSPPGGDISEPVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYKDSVGTYIDDKEKTDWNSKITRAMNYLQRESSLEEIVRLVGIDSLSENERLTMEIAKQIREDYLQQNAFDSVDTFTSFAKQEAMLSNILTFADQANHALELGSYFTEIIEGTVAVRDRMARSKYVSEDRLDEIKIISNEITHQIQLILETGGL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: FPRA_METJA
Sequence: MKKYESRRSKIADGVYWVGVLDWDIRMYHGYTLKGTTYNAYLVFGDEKVALIDNTYPGTSAQMWGRIKDAFEKEGREFKIDVIVQNHVEKDHSGALPEIHKKFPDAPIYCTEVAVEGLKKHYPSLKDAQFKVVHTGDTVDLGGKTLTFLEAPLLHWPDSMFTFYNEGGILFSNDAFGQHLCFPAHKRFDKDIPEYVLMDANQKFYANLITPLSKLVLKKFEEVIQLGLLEKIKMIAPSHGQIWTDPMKVIKAYQDFATGKAAKDKAVIVYDTMHYSTQKMAHAFAEGLMSEGIDVVMYFLHYDERSEIVKDILDAKAVLFGIPTIYDEPYPSIGDIIYYLRGLKFNRTGFKRLAVTFGSMGGEGGAVAKIAEDLAKCGFEVINQYELYYVPTEDELTNCYNMGKELAKRIKEMKIE
What is the function of this protein?
Catalyzes the oxidation of F420H(2) with O(2) (By similarity).  May be involved in O(2) detoxification, reducing the intracellular O(2) concentration to a level allowing growth at the expense of methane formation (By similarity).
What are the official names of this protein?
Coenzyme F420H(2) oxidase, FMN protein FprA, Flavoprotein A, Type A flavoprotein FprA.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
Protein: B_BPPHM
Sequence: MKKIELRPNGTKLVHTVNELPPETDQSFGKECDINFIVKKFIKTGQITHLARRQGFYGDQSSIPDFQTAMDTVTKAQQAFDELPAHMRKRFANSPHELMQFLQDPKNRDEAISLGLMEMVETPQQAPQSTTNQTTTKPAPASGEPTPVPTP
What is the function of this protein?
Participates in the assembly of the viral procapsid in the cytoplasm.  Internal scaffolding protein VP3 is released from the procapsid upon genome packaging, possibly through affinity displacement by the protein VP8, or by proteolysis (By similarity).
What are the official names of this protein?
Internal scaffolding protein VP3.
What is the protein family that this protein belongs to?
Belongs to the microvidae B protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: VF357_IIV6
Sequence: MILILTIIVGFLIYFVTAKRFKLKRLILSICFKTIYNVFKKWWLKFSEEGLKTIVFKRLSKFLKQPYYCNNNVVEYEFHNKKYKLMVNQSLIKKPSYFILNCKEGTGKKEDITLKLQPWIGPEHNFHNTLIKPSDLGYKKLIVVFSIGNKVVVNENDFLPTKLT
What are the official names of this protein?
Uncharacterized protein 357R.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 357R family.
Protein: MUTS_PHOV8
Sequence: MANDVVLTPMMKQFFELKAKHPDAIMLFRCGDFYETYSEDAIVASEILGITLTKRANGQAKSVEMAGFPFHALDTYLPKLVRAGKRVAICDQLEDPKMTKKLVKRGITELVTPGVAINDNVLSYKENNFLAAVHFGKASCGVAFLDISTGEFLTAEGPFDYIDKLLNNFAPKEVLFERGKRGMFEGNFGSKFFTFELDDWVFNESSSREKLLKHFETKNLKGFGVEHLKNGIVASGAILQYLNMTQHYQIGHITSLSRIEEDRYVRLDKFTVRSLELIGSMNEGGTSLLDVIDRTISPMGARLLKRWVVFPLKDEKPVNERLDVVEYFFREPDFKEFIEEKLHLIGDLERIVSKAAVGRISPREVVQLKVALQAIEPIKNACLNADNGSLRRIGEQLNLCLSIREKIAKEVKNDPPLLVNKGGVIADGVNAELDELRQIAFSGKDYLLKVQQRESELTGIPSLKIAYNNVFGYYIEVRNTHKDKVPADWIRKQTLVNAERYITQELKEYEEKILGAEDKILVLETKLYNELVVALAEFIPAIQINASQIARLDCLLAFANVAKENNYIRPVVEDSEVIDIRQGRHPVIEKQLPVGEKYIANDVFLDSETQQIIIITGPNMAGKSALLRQTALITLLAQMGSFVPAESARIGMVDKIFTRVGASDNISVGESTFMVEMNEAANILNNLSSRSLVLFDELGRGTSTYDGISIAWAIVEHIHEHPKAKARTLFATHYHELNEMEKSFKRIKNYNVSVKEIDNKVIFLRKLERGGSEHSFGIHVAKMAGMPKSIVKRANDILHQLETDNRQQGIAKPTAEIASGRSGMQLSFFQLDDPVLSQIRDEILNLDVNNLTPLEALNKLNDIKKIVKGK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: SART3_DANRE
Sequence: MAATGNEEQTLLPDIEEEAEGMEREMESEDDEEEGMGVEHSEEEDEEDTSEDERENEAEIQRLEEQLSINAFDYNCHVDLIKLLRQEGKLHRLRKARQKMSELFPLTEEIWLDWLKDEIRITEDESDREKVYELFERAIKDYVCPEIWLEYVQYSIGGMGAQGGIERVRSIFERALTAVGLHMTKGASIWEAYREFEIVILSTVQPPPGTVPSQEQQELLSAQLERIHTLFRRQLAVPLMDMEGTYAEYSDWADDGVPETVTHQYRRALQQMEKGKPYEEALLVSEPPKLAEYQSYIDFEIKEGDPARVQIIFERALAENCLVPDLWIKYTTYLDRQLKIKDLVLSAHERAVRNCPWTMGLWKSYLLALERHGADHQTVKDVFEKALNAGFIQATDYVEIWQSYLDYLRRRVDFSKEWSRELDELRAAFSRSLEYLKQDVEERFSESGDLSCTLMQIWARIEALHCKNMQKARELWDSIMTKGNAKYANMWLEYYNLERSYGDAAHCRKALHRAVQCTSDYPEHVCDVLLNFERVEGSLEDWDAAVQKTETKLNRVCEQRARVAEKEALHARQEEEKAEQRRKVKADKKAQKKGQKANRTGDKRKAEDDDEEEWGEEAELPSKRLRGEDDFDSTVTEELMETESGLFGRRAPPARKTEPPGFRKNQQGAPEPQRQPHDMPKEQRKDENCVFVSNLTFNMEDPEGKLRTLFQGCGTIQQVRPVFTAKGTFRGYCYVQFEDRLAVPEALKMDRQEVDGRPMYVSPCVDKNKNPDFKVFKYKTSMEKHKIFISGLPYSATKETLEDLCKEHGTIRAIRIVTNRSGKSKGLAYVEFEDEAQASQAVLKMDGTMLENFTLSVAISNPPGRRMKDEAAPSRFLGAAMPRQLQGARGKGRTQISLLPRSLYRQSTPDAKAENGTISAPHATVTDGETSLDTQTKSLSNEDFARMLLKK
What is the function of this protein?
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery.  Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:17416673).  May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity).
What are the official names of this protein?
Squamous cell carcinoma antigen recognized by T-cells 3, SART-3.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus speckle. Cytoplasm.
Protein: PSRP_ECOK1
Sequence: MDNAVDRHVFYISDGTAITAEVLGHAVMSQFPVTISSITLPFVENESRARAVKDQIDAIYHQTGVRPLVFYSIVLPEIRAIILQSEGFCQDIVQALVAPLQQEMKLDPTPIAHRTHGLNPNNLNKYDARIAAIDYTLAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLVLPASLKPLQHKLFGLTIDPERLAAIREERRENSRYASLRQCRMEVAEVEALYRKNQIPWINSTNYSVEEIATKILDIMGLSRRMY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: NDHO_SYNPW
Sequence: MAETPSSPAPAAKAPPALKKGALVRVNRAAYEGSVEAGASDPHPPAYIFEGPGELLVVKGTYGQVRWRRPVPDVWLRMDQLEAFS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit O, NAD(P)H dehydrogenase I subunit O, NDH-1 subunit O, NDH-O.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhO subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MBPHL_RAT
Sequence: METATTLEIASCSQRQVEEAADPADAEGPQTTRQQEAGSPSLQLLPSIEEHPKIWLPRALRQTYIRKVGETVNLLIPFQGKPKPQTIWTHNGSALDNSRVSVRNGEHDSILFIREAQRTDSGCYQLCVQLGGLQATATINILVIEKPGPPQSIKLVDVWGANATLEWTPPQDTGNTALLGYTVQKADKKSGLWFTVLERYHRTSCIVSDLIVGNSYAFRVFAENQCGLSDTAPVTADLAHIQKAATVYKAKGFAQRDLSEAPKFTQPLADCTTVTGYDTQLFCCVRASPKPKIIWLKNKMDLQGNPKYRALSQLGICSLEIRKPSPFDGGIYTCKAINALGEASVDCRVDVKAPH
What is the function of this protein?
Myosin-binding protein which plays a role in cardiac function.  Seems to regulate conduction in the atria and ventricular conduction systems.
What are the official names of this protein?
Myosin-binding protein H-like.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. MyBP family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere.
Protein: SUFE_YERPA
Sequence: MAGLPDRDKLIRNFSRCLNWEEKYLYIIELGGQLAPLTEQQRHPENLISGCQSQVWIAMTLSAEGHVIFAGDSDAAIVKGLVAVVFILYHDLTPQQIISLDVRPFFADLALSQHLTPSRSQGLEAMIRAIRTKVANLSAH
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BR14_AMOCU
Sequence: MFTLKKSLLLLFFLGTINLSLCEQERNADEEERRDDSDKRDVEVEKRFLSTLLNVASKVVPTLFCKITKKC
What is the function of this protein?
Antimicrobial peptide active against a variety of Gram-positive and some Gram-negative bacterial strains.  Has antifungal activity against C. albicans ATCC 10231 and a slime mold isolate.  Has hemolytic activity against human erythrocytes.
What are the official names of this protein?
Brevinin-1CG4.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: SSPK_BACLD
Sequence: MRNKSRGFPNMNNNKFEGEPRAKDDFASKRPDGSTNTHPQERMRASGKR
What are the official names of this protein?
Small, acid-soluble spore protein K, SASP K.
What is the protein family that this protein belongs to?
Belongs to the SspK family.
What are the subcellular locations of this protein?
Spore core.
Protein: PUR7_PELPB
Sequence: MKKTTQLYEGKAKKVFLTDDADLVIQEFKDDATAFNNKKKGSIAEKGVVNNAISSKLFTLLEAQGIRTHFVEKLSDRDMLCRYLDIIKVEVVVRNIAAGSLVKRYGFSEGTVLAMPIVEFYLKDDDLDDPLMNEAHAVALGVATLEELAFLKNRAEAINVLLKAFFAERKLKLVDFKLEFGRHNNEILLGDEISPDTCRFWDLETNEKMDKDRFRFDLGGVEDAYSEVQKRVLDLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CH10_STRPI
Sequence: MLKPLGDRVVLKIEEKEQTVGGFVLAGSAQEKTKTAQVVATGQGVRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN274_HUMAN
Sequence: MASRLPTAWSCEPVTFEDVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEHQLSKPDVVSQLEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQALYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQPTS
What is the function of this protein?
Probable transcription repressor.  Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression.  The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).
What are the official names of this protein?
Neurotrophin receptor-interacting factor homolog, Zinc finger protein 274, Zinc finger protein HFB101, Zinc finger protein with KRAB and SCAN domains 19, Zinc finger protein zfp2, Zf2.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: CLZ7_COCLU
Sequence: MERTSKYAEAIDTASQPETVIRASSVTGQQGHLNSVDMPLVETWRPEGPRASQQNHILLSPEQEVSQSSNTSPTSESDPQAFLEASEFPQNQTKTSRVDPVHMEIDDWAAIDQPMADSAQPDFEDWGDLGDLMPEVLPESSGTSSGAATDNGTAADDENRCWDHGCNGKKFLNHSNLVRHRRENGSARPKFICPMCGAYFSRSTARNQHLEKKSCNRVRRYSNGRERPRLRVKD
What is the function of this protein?
Transcription factor that probably regulates the expression of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS).
What are the official names of this protein?
C2H2-type zinc-finger transcription factor clz7, Squalestatin S1 biosynthesis cluster protein clz2, Zaragozic acid A biosynthesis cluster protein 7.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATP6_ORITI
Sequence: MLANPLSQFLIKPIIPLEALGYNISITNSAVAMIFVSIAASMLLITAFVNSKLVPSRWQAFGEILYESNIKLVHSIIGPQGKKFFPLILTLFLFISLGNILGMVPHAFTFTSHIIVTFSLAMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVIIELCVFISKPISLSLRLTANMVAGHILLKIIAWSIVSLTWLFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVNLH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DBH_MYCTO
Sequence: MNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFRPGAQFKAVVSGAQRLPAEGPAVKRGVGASAAKKVAKKAPAKKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKATKSPAKKVTKAVKKTAVKASVRKAATKAPAKKAAAKRPATKAPAKKATARRGRK
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU homolog, 21 kDa laminin-2-binding protein, 28 kDa iron-regulated protein, Irep-28, Histone-like protein, Hlp.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: M3K7_MOUSE
Sequence: MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIVATAGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
What is the function of this protein?
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Plays an important role in the cascades of cellular responses evoked by changes in the environment.  Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:10748100, PubMed:16157589, PubMed:21183079, PubMed:29291351).  Ceramides are also able to activate MAP3K7/TAK1.  Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7.  These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK).  Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK (PubMed:16157589, PubMed:8533096, PubMed:29291351).  MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis (PubMed:10748100).  In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B.  Promotes TRIM5 capsid-specific restriction activity (By similarity).  Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (PubMed:28842570).
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
Protein: HID1_HUMAN
Sequence: MGSTDSKLNFRKAVIQLTTKTQPVEATDDAFWDQFWADTATSVQDVFALVPAAEIRAVREESPSNLATLCYKAVEKLVQGAESGCHSEKEKQIVLNCSRLLTRVLPYIFEDPDWRGFFWSTVPGAGRGGQGEEDDEHARPLAESLLLAIADLLFCPDFTVQSHRRSTVDSAEDVHSLDSCEYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAMYLPPAPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSASSASPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLFFVLKSSDVLDILVPILFFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSIRVPMDIPVFTGTHADLLIVVFHKIITSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLFSAAQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRSIFHQLANLPTDPPTIHKALQRRRRTPEPLSRTGSQEGTSMEGSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVSEDGTLRSLEPEPQQSLEDGSPAKGEPSQAWREQRRPSTSSASGQWSPTPEWVLSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPVWYDTDVKLFEIQRV
What is the function of this protein?
May play an important role in the development of cancers in a broad range of tissues.
What are the official names of this protein?
Protein HID1, Down-regulated in multiple cancers 1, HID1 domain-containing protein, Protein hid-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the hid-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the cytosol and the Golgi apparatus.