PharMolix/UniProtQA huggingface dataset:
Protein: CLZ18_COCLU
Sequence: MIHKPIPNSKPLTAYIDGLRGLLSIIIFNAHLTPVIILGYDKVSRSQVSTSPRNVLDIPLVASCVNNWVLFTIPILKLVYSASPAVCLFFAISGYVMSLKWVRYMNHRSQTSEINSARIFTDFGSSIFRRTLRLSLLAMASMIVPFALMKTGFFDRTVVQQHGLTKLERGMRFWLEQWEQFPARHESWWEQTCDLVQNCARIFTVFMQRRDEAFSPRYNPVLWTIKADLRASLALTVTHLALLGTKRSSRLQILAALAVLGVAVGSLECPLFWAGWIIAEIHHAAEQTPLAQGKGTGQPRQKTNTAGMDTFGKTVVLALGCYVASYPTWKPEKAPMFNTFHMMTPGLIVPPRTWHSLGAVLVLYSLRDVPLARRICESSVAQFLGTHSFAIYLIHFCLVISFGPDLFSWVWSRTGHENLQSLAVGFGITYSILFMAVLLTAAIFRRFIESPVNKCVDSLYRSASVRKEA
What is the function of this protein?
Acyltransferase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS) (PubMed:28605916).  SQS1 is composed of a 2,8-dioxobicyclic[3. 2. 1]octane-3,4,5-tricarboxyclic acid core that is connected to two lipophilic polyketide arms (PubMed:28605916).  These initial steps feature the priming of an unusual benzoic acid starter unit onto the highly reducing polyketide synthase clz14, followed by oxaloacetate extension and product release to generate a tricarboxylic acid containing product (PubMed:28605916).  The phenylalanine ammonia lyase (PAL) clz10 and the acyl-CoA ligase clz12 are involved in transforming phenylalanine into benzoyl-CoA (PubMed:28605916).  The citrate synthase-like protein clz17 is involved in connecting the C-alpha-carbons of the hexaketide chain and oxaloacetate to afford the tricarboxylic acid unit (PubMed:28605916).  The potential hydrolytic enzymes, clz11 and clz13, are in close proximity to pks2 and may participate in product release (PubMed:28605916).  On the other side, the tetraketide arm is synthesized by a the squalestatin tetraketide synthase clz2 and enzymatically esterified to the core in the last biosynthetic step, by the acetyltransferase clz6 (By similarity).  The biosynthesis of the tetraketide must involve 3 rounds of chain extension (By similarity).  After the first and second rounds methyl-transfer occurs, and in all rounds of extension the ketoreductase and dehydratase are active (By similarity).  The enoyl reductase and C-MeT of clz2 are not active in the final round of extension (By similarity).  The acetyltransferase clz6 appears to have a broad substrate selectivity for its acyl CoA substrate, allowing the in vitro synthesis of novel squalestatins (By similarity).  The biosynthesis of SQS1 requires several oxidative steps likely performed by oxidoreductases clz3, clz15 and clz16 (Probable).  Finally, in support of the identification of the cluster as being responsible for SQS1 production, the cluster contains a gene encoding a putative squalene synthase (SS) clz20, suggesting a likely mechanism for self-resistance (Probable).
What are the official names of this protein?
Acyltransferase clz18, AT clz18, Squalestatin S1 biosynthesis cluster protein clz18, Zaragozic acid A biosynthesis cluster protein 18.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL25_RHOBA
Sequence: MPRSVPVMTDVIQVTKRESTGTAATRRLRRDGHVPAVLYGHGEANEHLAVPSAQVKGLLRHHSKTVQLSGDVDETALVSDMQWDPLGIEVLHMDLIRVNLKEKVELGVPIVLHGEAVGVREGGMLLENVHEVEIRCSAGSIPDNLVLEVSELGVGEHKTAGDLTLPEGVELITDVDVVIAHIEAQRDEEIAEAGDALAEPEVISKGSGEADE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: LTOR1_RAT
Sequence: MGCCYSSENEDSDQDQEERKLLLDPSNTPTKALNGAEPSYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP
What is the function of this protein?
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.  Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes.  Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes.  May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes.  May also play a role in RHOA activation (By similarity).  Involved in the control of embryonic stem cells differentiation; together with FLCN it is necessary to recruit and activate RRAGC/RagC and RRAGD/RagD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity).
What are the official names of this protein?
Ragulator complex protein LAMTOR1, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, Lipid raft adaptor protein p18.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR1 family.
What are the subcellular locations of this protein?
Late endosome membrane; Lipid- anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Lipid- anchor.
Protein: DCAM_YEAST
Sequence: MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine, a key step in the biosynthetic pathway for spermidine and spermine.  It is essential for normal growth, sporulation, and maintenance of ds-RNA virus.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: RN214_HUMAN
Sequence: MAASEVAGVVANAPSPPESSSLCASKSDEGLPDGLSTKDSAQKQKNSPLLSVSSQTITKENNRNVHLEHSEQNPGSSAGDTSAAHQVVLGENLIATALCLSGSGSQSDLKDVASTAGEEGDTSLRESLHPVTRSLKAGCHTKQLASRNCSEEKSPQTSILKEGNRDTSLDFRPVVSPANGVEGVRVDQDDDQDSSSLKLSQNIAVQTDFKTADSEVNTDQDIEKNLDKMMTERTLLKERYQEVLDKQRQVENQLQVQLKQLQQRREEEMKNHQEILKAIQDVTIKREETKKKIEKEKKEFLQKEQDLKAEIEKLCEKGRREVWEMELDRLKNQDGEINRNIMEETERAWKAEILSLESRKELLVLKLEEAEKEAELHLTYLKSTPPTLETVRSKQEWETRLNGVRIMKKNVRDQFNSHIQLVRNGAKLSSLPQIPTPTLPPPPSETDFMLQVFQPSPSLAPRMPFSIGQVTMPMVMPSADPRSLSFPILNPALSQPSQPSSPLPGSHGRNSPGLGSLVSPHGPHMPPAASIPPPPGLGGVKASAETPRPQPVDKLEKILEKLLTRFPQCNKAQMTNILQQIKTARTTMAGLTMEELIQLVAARLAEHERVAASTQPLGRIRALFPAPLAQISTPMFLPSAQVSYPGRSSHAPATCKLCLMCQKLVQPSELHPMACTHVLHKECIKFWAQTNTNDTCPFCPTLK
What are the official names of this protein?
RING finger protein 214.
Protein: KAD_HELPY
Sequence: MKQLFLIIGAPGSGKTTDAELIAKNNSETIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSGKGIILIDGYPRSVEQMQALDKELNAQNEVILKSVIEVEVSENTAKERVLGRSRGADDNEKVFHNRMRVFLDPLGEIQNFYKNKKVYKAIDGERSIEEIVGEMQEYILSFGN
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_BURPS
Sequence: MLYPTEFDVIVVGGGHAGTEAALASARMGAKTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAAATDEGGIQFRILNSSKGPAVRATRAQADRVLYKQAIRRRLENQPNLWLFQQAVDDLMVEGDRVVGAVTQVGVRFRARAVVLTAGTFLDGKIHVGLNHYTGGRAGDPAAVSLSSRLKELNLPQGRLKTGTPPRIDGRTIDFSKLDEQPGDLDPIPVFSFLGRAEQHPQQLPCWVTHTNERTHDIIRSGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFASKDSHQIFLEPEGLTTNEFYPNGISTSLPFDVQLALVHSMRGLEQAHILRPGYAIEYDYFDPRALKSSLETKAIGGLFFAGQINGTTGYEEAAAQGLLAGINAGRYAQEKDAWCPRRDQAYLGVLVDDLVTRGISEPYRMFTSRAEYRLSLREDNADMRLTEIGRELGVVDDVRWDAFNRKRDAVSRETERLRTTWVTPKTLPADEATALLGKPIDHEYSLAELLRRPGVSYDGVCGLRGGECGPSEPLAEDELLLAQIKEQIEIGIKYQGYIERQAGEIERNGANENTRLPDGIDYTEVRGLSFEVSQKLNQFRPETIGQASRISGMTPAAISLLMVHLKKRGLGRRKGADSVPGADVQADNTAAQQ
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_CHLAB
Sequence: MKESPVIKLRELLNLLPHRYPFLLVDKVLSYDLERRSIVAQKNVTINEPFFVGHFPEAPIMPGVLILESLAQAAGVLLGLVLENDRNKRLALFLGIHKAKFRQAVKPGDILTLSAEFSLISSKGGKASARACVGSQVAAEGELSFALVDKKSLD
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRAM4_HUMAN
Sequence: MKMSIWTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQSWPFRRLPLRPLIKMPCLEAFQAVLDGLDALLNLGVRPRRWKLQVLDLQDVCENFWMVWSEAMAHGCFLNAKRNKKPVEDCPRMKGRQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLILSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLLSCLKTSLKFLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLCVELYPAPRESYGADGTLCWSRFAQIRAELMNRVRDLRHPKRILFCTDYCPDCGNRSFYDLEADQYCC
What are the official names of this protein?
PRAME family member 4.
What is the protein family that this protein belongs to?
Belongs to the PRAME family.
Protein: ZEUS1_ARATH
Sequence: MKRICSVSSVQLFSRSFRALASPRSLNYPLQCIKRSSVRMESSNFSSGVRTESSVKPRGALIVLEGLDRSGKSTQCAKLLSFLNGLGHPTELWRFPDRETSVGQMISAYLSNKSQLDDHTIHLLFSANRWEKRSLMEEKLKTGTTLIVDRYSYSGVAFSSAKGLDIEWCKAPEIGLLAPDSVLYLDISPERAAERGGYGDERYERVEFQKKVADFYQTLGDSSWKIINASDAMEEVEKKIQQVVLDQVKECTEGKPLSLLWSS
What is the function of this protein?
Catalyzes the conversion of dTMP to dTDP (Probable).  Involved in the regulation of DNA replication.  Is essential to promote the first division of the zygote (PubMed:18036198).
What are the official names of this protein?
Thymidylate kinase, AtTMPK, Protein ZEUS1.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
What are the subcellular locations of this protein?
[Isoform 1]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus, nucleoplasm.
Protein: TRAC_ECOLI
Sequence: MNNPLEAVTQAVNSLVTALKLPDESAKANEVLGEMSFPQFSRLLPYRDYNQESGLFMNDTTMGFMLEAIPINGANESIVEALDHMLRTKLPRGIPLCIHLMSSQLVGDRIEYGLREFSWSGEQAERFNAITRAYYMKAAATQFPLPEGMNLPLTLRHYRVFISYCSPSKKKSRADILEMENLVKIIRASLQGASITTQTVDAQAFIDIVGEMINHNPDSLYPKRRQLDPYSDLNYQCVEDSFDLKVRADYLTLGLRENGRNSTARILNFHLARNPEIAFLWNMADNYSNLLNPELSISCPFILTLTLVVEDQVKTHSEANLKYMDLEKKSKTSYAKWFPSVEKEAKEWGELRQRLGSGQSSVVSYFLNITAFCKDNNETALEVEQDILNSFRKNGFELISPRFNHMRNFLTCLPFMAGKGLFKQLKEAGVVQRAESFNVANLMPLVADNPLTPAGLLAPTYRNQLAFIDIFFRGMNNTNYNMAVCGTSGAGKTGLIQPLIRSVLDSGGFAVVFDMGDGYKSLCENMGGVYLDGETLRFNPFANITDIDQSAERVRDQLSVMASPNGNLDEVHEGLLLQAVRASWLAKENRARIDDVVDFLKNASDSEQYAESPTIRSRLDEMIVLLDQYTANGTYGQYFNSDEPSLRDDAKMVVLELGGLEDRPSLLVAVMFSLIIYIENRMYRTPRNLKKLNVIDEGWRLLDFKNHKVGEFIEKGYRTARRHTGAYITITQNIVDFDSDKASSAARAAWGNSSYKIILKQSAKEFAKYNQLYPDQFLPLQRDMIGKFGAAKDQWFSSFLLQVENHSSWHRLFVDPLSRAMYSSDGPDFEFVQQKRKEGLSIHEAVWQLAWKKSGPEMASLEAWLEEHEKYRSVA
What is the function of this protein?
Required for the assembly of mature F-pilin subunits into extended F pili.
What are the official names of this protein?
Protein TraC.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ORN_XANC5
Sequence: MAENLAGNDRLIWIDLEMTGLDTDRDSIIEIATIVTDAQLNVLAEGPELAIAHPLETLEAMDEWNRNQHRRSGLWQRVLDSQVTHAQAEAQTVAFLSEWIRAGASPMCGNSICQDRRFLHRQMSRLERYFHYRNLDVSTIKELARRWAPSVANGFAKSSAHTALSDVRDSIDELRHYRQFMGALGGDAAAGVEG
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M2_I05A1
Sequence: MSLLTEVETPTRNEWECRCSDSSDPLIVAASIIGILHLILWILDRLFFKCIYRRLKYGLKRGPSTAGVPESMREEYRQEQQSAVDVDDGHFVNIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: GHRA_ENT38
Sequence: MDIIFYHPTFDTPYWINALTAALPGARVREWKRGDNEHADYALVWHPPVEMLQGRDLKAVFALGAGVDSILSKLKAHPEMLPEHIPLFRLEDTGMGQQMQEYAVSQVLHWFRRFDDYQALKQKSHWEPLADYQREDFTIGILGAGVLGSKVAEALAPWGFPLRCWSRSRKTYPGVQSFAGADELPAFLKGTRVLINLLPNTAETVGIINKGLLNQLADESYLMNLARGVHVIEEDLIDALNTGKLKGAMLDVYSSEPLPVESPLWAHPRVAMTPHIAAVTRPAEAVAYIARTIEHLEQGKAATRQVNRQLGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOA_SOLUE
Sequence: MPKSYTELYFPILLQAVIAMGLAAGLLTVSYLLGKKVRNRVKDMPYESGIVPTGDARHRFSVKFYLVGMLFILFDIEAIFLYPWVVVYRDLSRNGSLFGFYEMLTFVILILSGFFYIWKKGALDWGEPTARPGRK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRL1A_MOUSE
Sequence: MFSLPRGFEPPAPEDLGRQSSAELRERLRRQERLLRNEKFICKLPDKGKKISDTVAKLKAAISEREEVRGRSELFHPVSVDCKLRQKATTRADTDVDKAQSSDLMLDTSSLDPDCSSIDIKSSKSTSETQGPTHLTHRGNEETLEAGYTVNSSPAAHIRARAPSSEVKEHLPQHSVSSQEEEISSSIDSLFITKLQKITIADQSEPSEENTSTENFPELQSETPKKPHYMKVLEMRARNPVPPPHKFKTNVLPTQQSDSPSHCQRGQSPASSEEQRRRARQHLDDITAARLLPLHHLPAQLLSIEESLALQREQKQNYEEMQAKLAAQKLAERLNIKMQSYNPEGESSGRYREVRDEADAQSSDEC
What is the function of this protein?
Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II.  Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery.  Isoform 1 may play a role in Mediator-dependent regulation of transcription activation.  Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit GRINL1A, DNA-directed RNA polymerase II subunit M, Glutamate receptor-like protein 1A.
What is the protein family that this protein belongs to?
Belongs to the GRINL1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TBA_AJECA
Sequence: MREVVSLNVGQAGGQIANSCWELYCLEHGIQPDGYLTEERKAADPDQGFNTFFSETGQGKYVPRTIYCDLEPNVVDEVRTGPYRALFHPEQMITGKEDASNNYARGHYTVGKEMIDQCLDKVRRVADNCSGLQGFLVFHSFGGGQGSGFGALLMERLSVDYGKKTKLEFCVYPAPQNATSVVEPYNSILTTHTTLEHSDVQFMVDNEAIYDICRRNLGIERPSYENSNRLMAQGQSPITAIMLLFDCALNVDLNEFQTNLVPYPRIHFPLASYSPVVSAGKASHESNSVMEVTIVCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPKDVHAVAATLKTKRTVQFVDLQPTGFKIGICYQPPTMVPNGDLAKVNRACMLSNTTAISEAWTALSHKFDLIYSKRAFVHWYVGEGMEEGEF
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SFXN3_BOVIN
Sequence: MGELPLDINIQEPRWDQRTFLGRARHFFTVTDPRNLLLSGAQLEASRNIVQNYRAGIVTPGLTEDQLWRAKYVYDSAFHPDTGEKVVLIGRMSAQVPMNMTITGCMLIFYRKTPTVVFWQWLNQSFNAVVNYSNRSGDAPITVRQLGMAYVSATTGAVATALGLKSLTKHLPPLVGRFVPFAAVAAANCINIPLMRQRELQVGIPVTNEQGQRLGHSVAAAKKGIFQVVISRICMAIPAMAIPPVIMDTLEKKDFLKRRPWLGAPLQMGLVGFCLVFATPLCCALFPQRSSIHVSRLEPELRAQIQEQNPSIEVVYYNKGL
What is the function of this protein?
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway.  Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors.
What are the official names of this protein?
Sideroflexin-3.
What is the protein family that this protein belongs to?
Belongs to the sideroflexin family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: LGT_SALPA
Sequence: MTSSYLHFPDFDPVIFSIGPVALHWYGLMYLVGFVFAMWLAVRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPLFLDNPLYLFRVWDGGMSFHGGLIGVILVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPNFRFAMLFPGSRAEDIALLPSHPQWQPIFDTYGVLPRHPSQLYELALEGVVLFIILNLFIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIIAGAIMMVWAYRRRPQQHVS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CRGA_TROWT
Sequence: MSRKKHESSENNPVWFPTIMFGLMGTGAVWMVLFYISNGALPLPAVGTWNILIAFGIIMAGFAMMSRWK
What is the function of this protein?
Involved in cell division.
What are the official names of this protein?
Cell division protein CrgA.
What is the protein family that this protein belongs to?
Belongs to the CrgA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FCRLB_HUMAN
Sequence: MWPLTALLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYHPLLLELQPISTLWYLGHLLLPSHKKSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPVFEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIPVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDPASTTAPAPWAAALAPGNRPLSFRKPPVSRSVPLVTSVRNTTSTGLQFPASGAPTAGPPACAPPTPLEQSAGALKPDVDLLLREMQLLKGLLSRVVLELKEPQALRELRGTPETPTSHFAVSPGTPETTPVES
What are the official names of this protein?
Fc receptor-like B, Fc receptor homolog expressed in B-cells protein 2, FREB-2, Fc receptor-like and mucin-like protein 2, Fc receptor-like protein 2, Fc receptor-related protein Y, FcRY.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Note=Seems not to be secreted.
Protein: DNAJ_RICRS
Sequence: MSQNYYQILGVSKTASQADLKKAYLKLAKQYHPDTTDAKDAEKKFKAINAAYDVLKDEQKRAAYDRLGHDAFQNQQSRGGGGNHGGFHPDINDIFGDFFSDFMGGSRRSSRPTSAKVRGSDLKYNLTINLEEAFHGIEKNINFSSAVKCNTCHGSGSEKGETVTTCDACSGVGATRMQQGFFTIEQACHKCQGNGHIIKNPCKKCHGMGRYHKQRNLSVNIPAGVENGTRIRHTGEGEAGIRGGNSGDLYVDITIKPHDIYKVDGANLHCKLPISFVNAALGGEIEVPVIEGGKVSLTIPAGTQNGDQLRLRSKGMSKMRSTIRGDMLTHIHVEVPKNLSKRQRELLEEFKKESINEKENDGSFFNKMKSLWS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.