Protein: MEN2_MENTH
Sequence: MAGPVATSDRQQRLIFFGDQTVDALPCIKILTAQAHRLPALRRFLRDAADVIQVLLSSLEFDDHDHYRRFETICELAEIYSKQDGTHETIACALWTTAQFGDLVMRAELNPSILTGGQQSADPTYVVGICGGLLPAAATATARDINELLDIGRKLVAVAFRLGVAQWRRAMDIEGKPGRWAVTIVNVPAKQIRTILDAFNEDMEIPKHRQFYISFLAKGWVTVSGPPSLFPELWAYSSTLNAASKMQLPLGTPAHAAHLPPVNVSEIVGTGDVLDLTVRENFFTVSTSTCQPFQCQDLGSLLQESLRDITGKTLNIAGVNDYVISALDRNTPVRVSSFGPASQIASFKKTLEEAGYQVELDLGDPSLGNPEYPIDADSRDGSNLIAVVGQSVRFPGSEDVETFWENIKAGRSFETEIPASRFDLAHHYDATGSKTSSVTTKYGSFLENPGLFDNRLFNVSPREAKQMDPIQRILMMCSYEALQAAGYSPDGSLSTNSMRIATYFGQSGDDWRQVRASQEVDIYYIPGTVRSFAPGKLNYHYKWGGGNYAVDSACAASTTTMMLASQALLARDCDMALAGGGQLNAAPEPYAGLSRAGFLSKTTGGCKTFREDADGYCRGEGVGVVVLKRLEDALAENDNVLAVIRGADRNFSWDATSITHPSVSAQVKLVKSVLRNTGVEPEEIGFVEMHGTGTQAGDGVEMETVTTVFGSRPKDNPLYVGAVKANIGHGEAAAGVASVIKAIEVLRHRTIPTQAGFPGPRDPKFNHLDGMNIRIPESVVPFQPAPAPFSSDGKRKVLVNNFDASGGNNCVLLEEAPARDRETTADPRGVYTVAVSARTTNSLKNNISRLLGYLQSHPDASVADVAYTTTARRMHEDLKKAYTVQTASELVSLLQADLKKDLTAVQYRSPHSVVFAFTGQGAQYAGMGKQLFDTSAAFRESVQAFHELAVWQGFPEFLHLIADDQADVKAADPVQLQLAVVVLEMALANLWKSWGVEPGLVVGYSLGEYPALYVAGVLSVHDVIFLVGNRARLMQERCESGSYAMLATQSSPQDLEQVLGAYPSCAVACKGAPRSTVVSGPTEDITQLHSELKEKNINGTLLNVPYGFHCAQVDPILDDFRDMADGIQFNKPRIPVASSLEGTVVTEEGVFSSAYLVRQTREPVNFIGAVKAAESSGRADNTTVWIEIGPKRVLSSLVKSTLSADQGRLLHTIDDKDSNWKTIAAAMTAGYTEGMSIKWPKFHKLFSKHLTLLELPTYAFDLKDYWIPPAVPVTAAAPVAAPAADPSLPVIPVVPGFPTASLQQVRSEQINGDEAKVTFETVISHPALLAVIRGHRVGGVDLFPASGFMDMAFSAAKYIHHRTKSGQPVPEISMKHLAITHPLTPSSGQSRQIVIVTASKRSGSSVVDVSFRSRDGSAEQDHGDCKLHFDKRGSWDAEWAQTAHFINAAKKNVIANGTSPAGTGHRLPKSVVYKLFSSLVEYSGAFRAMEEVYVTDDFQKEAVASVVLPGGSSEFYVNPYWSDALIHVCGFLLNSSPNLPSQDCFLFNGLEEMRLLSDDLQPGIPYTSYVYLTEPGSSPDSQAPRPKHARGDVYVFQGEKIVGVAKGVVFQRLTRRVLATVLGGKLPGAAAPVREIAAPAPIRAVAPAPAPVAPRPVEMYRVPGVVGDEKADAAIGKILARAGANPAHITDATTFAEIGFDSLEWIELVREIRTSLDLEVPASFFFEYPKVNGLRRAISELSLDYQGPASGSVSVSSSATTTHGMTTPSSTSSAQSSQSSQTPDGPGIYANAVIDIVLSQTGFDKADLLPTTRFDDMGLDSLCTMEVVGVVREQTGLDLPASFFHQNPTVAHVRRALGSDSDGDSKPKSAPAPPAPEPVVEVAAPAPAVQAPPAILDGDLASYHCDFFLMQGSSDSTKTPLFFLPDGTGYPAVLLKLPPIFEGDNALFTCKSPLLNVAEGREVRCTIEGLAAAYAAAIQRARPHGPYLLAGYSLGGAYAFEVAKILADAGEVVQGLLFVDFNMAASVGKLHRDRNPVPVDLTVGAMEKTGWMQGIQNDDKDFNIPPAPPKIKFHALSVFKSLISYYPTPMTPSQRPRNTYALWAGIGMQDLLGTKNAGFLPAYGIIDWQMGDRHENNGPAGWEEYIGGPVKCATMPCDHLSLLMSHHWIPKSAEVIKGLLKDAMDN
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of menisporopsin A, a bioactive macrocyclic polylactone (PubMed:30556556).  The biosynthesis of menisporopsin A is performed by a reducing (man1) and a non-reducing (men2) polyketide synthase that catalyze the formation of each menisporopsin A subunits, while the esterification and cyclolactonization activities are probably peformed by the unusual thioesterase domain of men2 (PubMed:30556556).  First, a reduced diketide intermediate, 3-hydroxybutyryl-S-ACP is produced by men1 and transferred to men2; this is followed by a second reduced diketide which is further elongated using 3 units of malonyl-coA to form a reduced pentaketide.  The cyclization of this intermediate by the PT domain forms the second subunit, 2,4-dihydroxy-6-(2-hydroxy-n-propyl)benzoyl-S-ACP (PubMed:30556556).  The TE domain of men2 then esterifies the secondary hydroxyl group on the side chain of the second subunit with the acyl-TE of the first subunit to form the first ester intermediate (PubMed:30556556).  This process occurs iteratively to form a linear tetraester intermediate (PubMed:30556556).  The final subunit is formed by a similar process, except that an extra malonyl-CoA is required in an additional elongation step to form a reduced hexaketide intermediate, and the carbonyl group next to the secondary hydroxyl group is reduced by a trans-acting ketoreductase (PubMed:30556556).  Again, the PT domain catalyzes cyclization to form the largest subunit, 2,4-dihydroxy-6-(2,4-dihydroxy-n-pentyl) benzoyl-S-ACP (PubMed:30556556).  Then the linear pentaester intermediate is formed (PubMed:30556556).  In this step, if the intermediate transfer rate is slow, intra- molecular cyclization involving the secondary hydroxyl group of the pentaester intermediate may occur to form menisporopsin B (PubMed:30556556).  Alternatively, transfer of the pentaester intermediate to the TE domain would allow cyclolactonization to be catalyzed by the TE to form menisporopsin A (PubMed:30556556).
What are the official names of this protein?
Non-reducing polyketide synthase men2, NR-PKS men2.