PharMolix/UniProtQA huggingface dataset:
Protein: TSAD_ACIB3
Sequence: MIVLGLETSCDETGLALYDSELGLRGQVLYSQIKLHAEYGGVVPELASRDHVRKLIPLMNQLLEQSGVKKQEIDAVAYTRGPGLMGALMTGALFGRTLAFSLNKPAIGVHHMEGHMLAPLLSSQPPEFPFVALLVSGGHTQLMAAHGIGQYELLGESIDDAAGEAFDKVAKMMNLPYPGGPNIAKLALSGDPLAFEFPRPMLHQGLDFSFSGLKTAVSVQLKKLNGENRDADIAASFQEAIVDTLVKKSVKALKQTGLKRLVIAGGVSANLRLREQLETSLAKIKAQVYYAEPALCTDNGAMIAFAGYQRLKAGQHDGLAVTTTPRWPMTELTIPE
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLIT3_MOUSE
Sequence: MALGRTGAGAAVRARLALGLALASILSGPPAAACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSIIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCSNNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFVPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRFSSECFMDLVCPEKCRCEGTIVDCSNQKLARIPSHLPEYTTDLRLNDNDISVLEATGIFKKLPNLRKINLSNNRIKEVREGAFDGAAGVQELMLTGNQLETMHGRMFRGLSSLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHMAWLGRWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCVETVVRCSNRGLHALPKGMPKDVTELYLEGNHLTAVPKELSAFRQLTLIDLSNNSISMLTNHTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPESMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCSQDPVEQYRCTCPYSYKGKDCTVPINTCVQNPCEHGGTCHLSENLRDGFSCSCPLGFEGQRCEINPDDCEDNDCENSATCVDGINNYACLCPPNYTGELCDEVIDYCVPEMNLCQHEAKCISLDKGFRCECVPGYSGKLCETNNDDCVAHKCRHGAQCVDEVNGYTCICPQGFSGLFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVGSNSPLYLGGIPTSTGLSALRQGADRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCRHGLCRSVEKDSVVCECHPGWTGPLCDQEARDPCLGHSCRHGTCMATGDSYVCKCAEGYGGALCDQKNDSASACSAFKCHHGQCHISDRGEPYCLCQPGFSGHHCEQENPCMGEIVREAIRRQKDYASCATASKVPIMECRGGCGSQCCQPIRSKRRKYVFQCTDGSSFVEEVERHLECGCRACS
What is the function of this protein?
May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
What are the official names of this protein?
Slit homolog 3 protein, Slit-3, Slit3.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPE_MYCBT
Sequence: MAELNVEIVAVDRNIWSGTAKFLFTRTTVGEIGILPRHIPLVAQLVDDAMVRVEREGEKDLRIAVDGGFLSVTEEGVSILAESAEFESEIDEAAAKQDSESDDPRIAARGRARLRAVGAID
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NAPA_CAMJE
Sequence: MNRRDFIKNTAIASAASVAGLSVPSSMLGAQEEDWKWDKAVCRFCGTGCGIMIARKDGKIVATKGDPAAPVNRGLNCIKGYFNAKIMYGEDRLVMPLLRMNEKGEFDKKGKFQQVSWQRAFDEMEKQFKKAYNELGVTGIGIFGSGQYTIQEGYAALKLAKAGFRTNNIDPNARHCMASAVVGFMQTFGVDEPSGCYDDIELTDTIITWGANMAEMHPILWSRVSDRKLSNLDKVKVVNLSTFSNRTSNIADIEIIFKPNTDLAIWNYIAREIVYNHPEAMDMKFIKDHCVFATGYADIGYGMRNNPNHPKFKESEKDTVEKENVITLDDEEATSLSYLGVKAGDKFEMKHQGVADKNWEISFDEFKKGLAPYTLEYTARVAKGDDNESLEDFKKKLQELANLYIEKNRKVVSFWTMGFNQHTRGSWVNEQAYMVHFLLGKQAKPGSGAFSLTGQPSACGTAREVGTFSHRLPADMVVANPKHREISEKIWKVPAKTINPKPGSPYLNIMRDLEDGKIKFAWVQVNNPWQNTANANHWIAAAREMDNFIVVSDCYPGISAKVADLILPSAMIYEKWGAYGNAERRTQHWKQQVLPVGAAMSDTWQILEFAKRFKLKEVWKEQKVDNKLTLPSVLEEAKAMGYSEDDTLFDVLFANKEAKSFNPNDAIAKGFDNTDVKGDERKIQGSDGKEFTGYGFFVQKYLWEEYRKFGLGHGHDLADFDTYHKVRGLRWPVVNGKETQWRFNTKFDYYAKKAAPNSDFAFYGDFNKMLTNGDLIAPKDEKEHSIKNKAKIFFRPFMKAPERPSKEYPFWLATGRVLEHWHSGTMTMRVPELYRAVPEALCYMSEKDGEKLGLNQGDLVWVESRRGKVKARVDMRGRNKPPVGLVYVPWFDENVYINKVTLDATCPLSKQTDFKKCAVKIYKA
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: OBG_STAA3
Sequence: MFVDQVKISLKAGDGGNGITAYRREKYVPFGGPAGGDGGKGASVVFEVDEGLRTLLDFRYQRHFKASKGENGQSSNMHGKNAEDLVLKVPPGTIIKNVETDEVLADLVEDGQRAVVAKGGRGGRGNSRFATPRNPAPDFSEKGEPGEELDVSLELKLLADVGLVGFPSVGKSTLLSIVSKAKPKIGAYHFTTIKPNLGVVSTPDQRSFVMADLPGLIEGASDGVGLGHQFLRHVERTKVIVHMIDMSGSEGREPIEDYKVINQELAAYEQRLEDRPQIVVANKMDLPESQDNLNLFKEEIGEDVPVIPVSTITRDNIDQLLYAIADKLEEYKDVDFTVEEEESVGINRVLYKHTPSQDKFTISRDDDGAYVVSGNAIERMFKMTDFNSDPAVRRFARQMRSMGIDDALRERGCKNGDIVRILGGEFEFVE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLAF5_MOUSE
Sequence: MAQRHLWIWFLCLQTWSEAAGKDADPMVMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYKADINEENEETITKIYYLHIYRRLKTPKITQSLISSLNNTCNITLTCSVEKEEKDVTYSWSPFGEKSNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTVQQPCTDTPSFHPRHAVLPGGLAVLFLLILIPMLAFLFRLYKRRRDRIVLEADDVSKKTVYAVVSRNAQPTESRIYDEIPQSKMLSCKEDPVTTIYSSVQLSEKMKETNMKDRSLPKALGNEIVV
What is the function of this protein?
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.  SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.  Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:20962259).  Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (PubMed:20962259).  Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process.  Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway.  May serve as a marker for hematopoietic progenitor cells (By similarity).  Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation (PubMed:20153220).  In germinal centers involved in maintaining B cell tolerance and in preventing autoimmunity (PubMed:25801429).  In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (By similarity).  In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (PubMed:20628063).  Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (By similarity).
What are the official names of this protein?
SLAM family member 5, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PYRC_BACCR
Sequence: MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQKRIEEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRAAKLDMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRVIRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDMIATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGVITLEQLIQFLTEKPADTFGLEAGRLKEGRAADITIIDLEQEEEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIAWQKESALV
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: KATG_BURP6
Sequence: MSNEAKCPFHQAAGNGTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAVKRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDVYWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDTFARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGADAITSGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKKHRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVPAEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGANGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVEQAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDKAQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAADADVFEGRDRATGALKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVMNLDRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RISB_NOSS1
Sequence: MAVFEGTFTQTEPLRLAVVIGRFNDLVTTKLLAGCQDCLKRHGVDPDPHGNQVDYVWVPGSFEVPLVARQLALTHRYDAIICLGAVIRGQTPHFDYVSAEVSKGIAAASFQTGVPVIFGILTVDTMQQALERAGIKANHGWDYAMNALEMASLMRQLRSNVTDSYSQTQSLPAAFPNASIGKLTAESEEV
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: DSBD_CROS8
Sequence: MAHRILTLILLFCSAHASASLFGQQNASQFVPADQAFAFDFQQQQHQLTLNWQIKPGYYLYRQQIRVTPANASVAPPALPTGEPHEDEFFGKSEIYRDALSVPVTVEQAAPGATLSVTYQGCAEAGFCYPPETRTVPLSAVEPTESVKANAATPSAATGEQTRVNSDSPSATLPFSAFWALLIGIGVAFTPCVLPMYPLISGIVLGGDKRLSTRRALLLAFIYVQGMALTYTALGLVVAAAGLQFQAALQSPWVLVTLSAVFVLLALSMFGLFTLQLPASLQTRLTLMSNRQRGGSPGGVFAMGAIAGLICSPCTTAPLSAILLYIAQSGNLWLGGGTLYLYALGMGLPLILVTVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVLGEPWGVRLWSVLGVAFFGWAFVTSLNATRSWMRAVQIVLLGAAMICARPLQDWVFGAPVAESQAHLAFTRIATVDDLDRALAQAKGKPVMLDLYADWCVACKEFEKYTFSAPEVQRALDGAVLLQADVTANSAADVALLKRLNVLGLPTIIFFDAQGNEIPNGRVTGFMDAPAFATHLHNRLR
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPB_PSEA2
Sequence: MKLLSLTGVAGVLATCVAATPLVKRLPSGSDPAFSQPKSVLDAGLTCQGASPSSVSKPILLVPGTGTTGPQSFDSNWIPLSTQLGYTPCWISPPPFMLNDTQVNTEYMVNAITALYAGSGNNKLPVLTWSQGGLVAQWGLTFFPSIRSKVDRLMAFAPDYKGTVLAGPLDALAVSAPSVWQQTTGSALTTALRNAGGLTQIVPTTNLYSATDEIVQPQVSNSPLDSSYLFNGKNVQAQAVCGPLFVIDHAGSLTSQFSYVVGRSALRSTTGQARSADYGITDCNPLPANDLTPEQKVAAAALLAPAAAAIVAGPKQNCEPDLMPYARPFAVGKRTCSGIVTP
What is the function of this protein?
Hydrolysis of triglycerides.  Is very stereospecific both in hydrolysis and in organic synthesis and has a potentially important application in glucolipid synthesis.
What are the official names of this protein?
Lipase B, CALB.
Protein: MEPC_PSEPU
Sequence: MTKSLLSLAVTAFILGGCSLIPDYQTPEAPVAAQWPQGPAYSPTQSADVAAAEQGWRQFFHDPALQQLIQTSLVNNRDLRVAALNLDAYRAQYRIQRADLFPAVSATGSGSRQRVPANMSQTGESGITSQYSATLGVSAYELDLFGRVRSLTEQALETYLSSEQARRSTQIALVASVANAYYTWQADQALFKLTEETLKTYEESYNLTRRSNEVGVASALDVSQARTAVEGARVKYSQYQRLVAQDVNSLTVLLGTGIPADLAKPLELDADQLAEVPAGLPSDILQRRPDIQEAEHLLKAANANIGAARAAFFPSISLTANAGSLSPDMGHLFSGGQGTWLFQPQINLPIFNAGSLKASLDYSKIQKDINVAKYEKTIQTAFQEVSDGLAARKTFEEQLQAQRDLVQANQDYYRLAERRYRIGIDSNLTFLDAQRNLFSAQQALIGDRLSQLTSEVNLYKALGGGWYEQTGQANQQASVETPKG
What is the function of this protein?
The outer membrane component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.
What are the official names of this protein?
Multidrug/solvent efflux pump outer membrane protein MepC.
What is the protein family that this protein belongs to?
Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: ATPA_STAAS
Sequence: MAIKAEEISALLRSQIENYESEMSVTDVGTVLQIGDGIALIHGLNDVMAGELVEFHNGVLGLAQNLEESNVGVVILGPYTGITEGDEVKRTGRIMEVPVGEELIGRVVNPLGQPIDGQGPINTTKTRPVEKKATGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIAIDTILNQKDQGTICIYVAIGQKDSTVRANVEKLRQAGALDYTIVVAASASEPSPLLYIAPYSGVTMGEEFMFNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDLGGGSITALPIIETQAGDISAYVPTNVISITDGQIFLQSDLFFSGVRPAINAGQSVSRVGGSAQIKAMKKVAGTLRLDLASYRELESFAQFGSDLDEFTASKLERGKRTVEVLKQDQNKPLPVEHQVLIIYALTKGYLDDIPVVDITRFEDELNHWAESNATELLNEIRETGGLPDAEKFDTAINEFKKSFSKSE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ZIP8_ARATH
Sequence: MATTTQHMNQIFLVLLLISFAISPAISTVPKECETDSTDSCIDKTKALPLKIVAIVAILVTSMIGVAAPLFSRYVTFLHPDGKIFMIIKCFASGIILGTGFMHVLPDSFEMLSSPCLEDNPWHKFPFTGFVAMLSGLVTLAIDSIATSLYTKKAVADDSEERTTPMIIQIDHLPLTTKERSSTCSKQLLRYRVIATVLELGIIVHSVVIGLSLGATNDTCTIKGLIAALCFHQMFEGMGLGGCILQAEYTNVKKFVMAFFFAVTTPSGIALGIALSSVYKDNSPTALITVGLLNACSAGLLIYMALVDLLAAEFMGSMLQRSVKLQLNCFGAALLGCGGMSVLAKWA
What is the function of this protein?
Probably mediates zinc uptake from the rhizosphere.
What are the official names of this protein?
Probable zinc transporter 8, ZRT/IRT-like protein 8.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM2_STAAW
Sequence: MKFDRHRRLRSSATMRDMVRENHVRKEDLIYPIFVVEKDDVKKEIKSLPGVYQISLNLLESELKEAYDLGIRAIMFFGVPNSKDDIGTGAYIHDGVIQQATRIAKKMYDDLLIVADTCLCEYTDHGHCGVIDDHTHDVDNDKSLPLLVKTAISQVEAGADIIAPSNMMDGFVAEIRRGLDEAGYYNIPIMSYGVKYASSFFGPFRDAADSAPSFGDRKTYQMDPANRLEALRELESDLKEGCDMMIVKPALSYLDIVRDVKNHTNVPVVAYNVSGEYSMTKAAAQNGWIDEERVVMEQMVSMKRAGADMIITYFAKDICRYLDK
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: MSRP_SALTY
Sequence: MKKIRPLTEADVTAESAFFMQRRQVLKALGISAAALSLPSTAQADLFSWFKGNDRPKAPAGKPLEFSQPAAWRSDLALTPEDKVTGYNNFYEFGLDKADPAANAGSLKTEPWTLKISGEVAKPFTLDYDDLTHRFPLEERIYRMRCVEAWSMVVPWIGFPLYKLLAQAQPTSHAKYVAFETLYAPDDMPGQKDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPIRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLSAPNEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYANEVASLYRGLNLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: GUAA_SALCH
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVPAEERFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: PURA_TERTT
Sequence: MGKNVVVLGTQWGDEGKGKIVDLLTEQVTHVARFQGGHNAGHTLVIDGKKTVLHLIPSGILHSGVTCFIGNGVVLAPDALMKEIHELEAQEVPVRERLKLSPACPLILPYHVALDQARELKRGEAKIGTTGRGIGPAYEDKVSRRGLRLGDLLHEERFATKLKEVMEYHNFALTQYYGAEAVDYQAVLDEALLLAKELRPMIVDVSDELHLAREAGKNILFEGAQGSLLDIDHGTYPFVTSSNTTAGGTATGSGFGPLYLDYVLGITKAYTTRVGAGPFPTELDCEVGEHLGVKGHEFGATTGRKRRTGWFDAVAVKHAVRINSMSGMCLTKLDVLDGLKEVKICVGYKNSAGEDVGIPCDAEGWEDIQPVYESLPGWSESTVGAKSVDALPQAARDYIARLEALVGITVDIISTGPDRVETIILKSPFA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_NOCFA
Sequence: MRVGIGSDVHPIEPGRPCWMAGLLFEGEDGCSGHSDGDVAAHALCDALLSAAGLGDVGAVFGTGRPEWADVSGAAMLTEVRRLLGEAGFEVVNAAVQVIGNRPKIGPRRAEAQRVLGDLLDAPVSVSGTTTDGLGLTGRGEGIAAVATALLRPRV
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: VP4_ROTEO
Sequence: MASLIYRQLLANSYTVDLSDEIENIGYAKSKNVTINPGPFAQTGYAPVNWGPGEVNDSTTVEPVLDGPYQPTNFNPPVNYWMLLSPLNAGVVVEGTNSIDRWLATVLVEPNVTTTVRTYTLFGVQEQISVENNSTTKWKFINLIKTTPSGNFTLYSTLLSEPKLHGIMKHGGQLWVYNGETPNATTTGYVTSNYDSLTMTSFCDFYIIPRNQESTCTEYINNGLPPIQNTRNVVSVSISSRNIIHNRAQVNEDIVISKTSLWKEVQYNRDITIRFRFANAIIKSGGLGYKWSEISFKPANYQYTYTRDGEEITAHTTCSVNGVNDFSFNGGSLPTDFVISRYEVIKENSYVYVDYWDDSQAFRNVVYVRSLAANLNDVLCTGGDYNFALPVGQWPVMTGGAVMLHAAGVTLSTQFTDFVSLNSLKFRFSLSAEEPYFSITRTRVTRLYGLPAVNPNNDRDYYEIAGRFSLISLVPSNDDYQTPIMNSVTVRQDLERQLGELREEFNALSQEIAISQLIDLALLPLDMFSMFSGIKSTIDAAKSMATNVMKKFKKSKLASSVSTLTDSLSDAASSVSRSSSIRSVSSSVSAWTDVSDQLTDISNSVNSISTQTSTISRRLRLKEIATQTEGMNFDDISAAVLKTKIDKSTQIAANNIPDVITEASEKFIPNRAYRVISNDNVFEASTDGRFFAYKVGTFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGITREQAFNLLRSDPRVLREFINQDNPIIKNRIEQLILQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: ERPA_STUS1
Sequence: MSVESFTPTAIQFSQGAASKVKSLVDEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDVADDDTVIEREGVSLVVDPMSYQYLAGAEVDYQEGLEGSRFVIKNPNATTTCGCGQSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: RL23_LEPIC
Sequence: MNLQDVILTPIVTEKSQDLETIGANSKKGTRMVKYTVKVHIDANKTLIKEAFKKIFKVTPSSVNVQVYRGKIKRFRNMPAARPHWKKAIVTFRDGASIDFAKEA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.