PharMolix/UniProtQA huggingface dataset:
Protein: SAC2_HUMAN
Sequence: MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYCHRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI
What is the function of this protein?
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate.  May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669).  Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669).  Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).  Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455).  Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity).  May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).
What are the official names of this protein?
Phosphatidylinositide phosphatase SAC2, Inositol polyphosphate 5-phosphatase F, Sac domain-containing inositol phosphatase 2, Sac domain-containing phosphoinositide 4-phosphatase 2, hSAC2.
What are the subcellular locations of this protein?
Membrane, clathrin-coated pit. Early endosome. Recycling endosome. Note=Also found on macropinosomes.
Protein: UREE_BURP1
Sequence: MRTIDKRIAPNVRLAATLVARAPALTLAYDARCKSRLAATLDTGEDVALVLPRGTVLRDGDVLVADDGALVRVAAAHEAVLLVRAPDALTLTRAAYHLGNRHTPVEVGAGCLKLEYDPVLADMLTRLGATVERASAPFQPEAGAYGGGHRHGHDATFAEDYALAQQVFDEHHGHSHSRSHDHDHDHDHQHGPSCSHGHHHGHR
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_ECOLU
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIITIAGQELNEKGFRADDIQIRDADTLLEVSENSKRAVILVAAWLGDARLIDNKIVELV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CF062_MOUSE
Sequence: MGDPNSRKKQALNRLRAQLRKKKESLADQFDFKMYIAFVFKEKKKKSALFEVSEVIPVMTNNYEENILKGVRDSSYSLESSLELLQKDVVQLHAPRYQSMRRDVIGCTQEMDFILWPRNDIEKIVCLLFSRWKESDEPFRPVQAKFEFHHGDYEKQFLHVLSRKDKTGIVVNNPNQSVFLFIDRQHLQTPKNKATIFKLCSICLYLPQEQLTHWAVGTIEDHLRPYMPE
What are the official names of this protein?
Uncharacterized protein C6orf62 homolog.
Protein: PTPD1_MDBVW
Sequence: MRRPNCIAEILRQHTQIIEESNNYYYLKMKTKDNKSQGPLRSLLCLPKNVNQKTDSAFCSVDGYNVKNKFLCTRSPNQDSLYQFWSMAYKKNIHIIVMLSPIDNLMRHRYWSLEEDEVFECREFRIRLRSSAQWIQFLKK
What are the official names of this protein?
Truncated tyrosine phosphatase D1, PTP-D1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: PSTB_PSEPU
Sequence: MQQDSHTHGIDMSALGRNKQGLQLAEETVAIEVPGLSLFYGDKQALFDVSMNIPKQRVTAFIGPSGCGKSTLLRTFNRMNDLVDGCRVEGAINLYGNNIYRKGEDVAELRRRVGMVFQKPNPFPKTIYENVVYGLRIQGINKKRVLDEAVEWALKGAALWDEVKDRLHESALGLSGGQQQRLVIARTIAVEPEVLLLDEPCSALDPISTLKVEELIYELKSKYTIVIVTHNMQQAARVSDYTAFMYLGKLVEFGDTDTLFTNPAKKQTEDYITGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: IF4F2_YEAST
Sequence: MTDQRGPPPPHPQQANGYKKFPPHDNQYSGANNSQPNNHYNENLYSAREPHNNKQYQSKNGKYGTNKYNNRNNSQGNAQYYNNRFNNGYRLNNNDYNPAMLPGMQWPANYYAPQMYYIPQQMVPVASPPYTHQPLNTNPEPPSTPKTTKIEITTKTGERLNLKKFHEEKKASKGEEKNDGVEQKSKSGTPFEKEATPVLPANEAVKDTLTETSNEKSTSEAENTKRLFLEQVRLRKAAMERKKNGLISETEKKQETSNHDNTDTTKPNSVIESEPIKEAPKPTGEANEVVIDGKSGASVKTPQHVTGSVTKSVTFNEPENESSSQDVDELVKDDDTTEISDTTGGKTVNKSDDETINSVITTEENTVKETEPSTSDIEMPTVSQLLETLGKAQPISDIYEFAYPENVERPDIKYKKPSVKYTYGPTFLLQFKDKLKFRPDPAWVEAVSSKIVIPPHIARNKPKDSGRFGGDFRSPSMRGMDHTSSSRVSSKRRSKRMGDDRRSNRGYTSRKDREKAAEKAEEQAPKEEIAPLVPSANRWIPKSRVKKTEKKLAPDGKTELFDKEEVERKMKSLLNKLTLEMFDSISSEILDIANQSKWEDDGETLKIVIEQIFHKACDEPHWSSMYAQLCGKVVKDLDPNIKDKENEGKNGPKLVLHYLVARCHEEFEKGWADKLPAGEDGNPLEPEMMSDEYYIAAAAKRRGLGLVRFIGYLYCLNLLTGKMMFECFRRLMKDLNNDPSEETLESVIELLNTVGEQFEHDKFVTPQATLEGSVLLDNLFMLLQHIIDGGTISNRIKFKLIDVKELREIKHWNSAKKDAGPKTIQQIHQEEEQLRQKKNSQRSNSRFNNHNQSNSNRYSSNRRNMQNTQRDSFASTKTGSFRNNQRNARKVEEVSQAPRANMFDALMNNDGDSD
What is the function of this protein?
Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus.  Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity.  The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability.  TIF4632 is probably essential when TIF4631 is missing.
What are the official names of this protein?
Eukaryotic initiation factor 4F subunit p130, eIF-4F p130, eIF4F p130, Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 2, eIF4G2, mRNA cap-binding protein complex subunit p130.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4G family.
Protein: TRMB_ZYMMO
Sequence: MTESSIHDPLTIRRLYGRQQGHSLRPKQAELVETLLPQLEITTEQAVSATDLFGDDRPLEFEIGFGKGEHLAGQAMMRPDHGFIGCEPFLDGVVGLLTHIDNNQIKNIRLHRGDALDILEQLPDGCLDRAYLLHPDPWPKARHAKRRFMNHGPIGLIARKMKKGGEFRFGTDHPIYCHWAMMIMGQRPDFEWLAQTPRDFLQRPEDWPQTRYEKKAREKGHEVWYFRYRRV
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: FTHS_SHEB5
Sequence: MLTDMDISSRASLKNITEIGADLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVTAVTPTPHGEGKTVTSIGLTQSLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQEMNLHLTGDIHAVSSAHNLGAAAIAARLFHETRLGKTEFEAQSEQAFLDIDPNEIRWHRVVDHNDRCLRQIHVGLGDNNGPEYESSFDITAASELMAILALSHDLADMRARIGRLVLALNTQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDIALRLADFVVTEGGFGSDMGFEKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSNVSNIHVPNISATNINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDSDAELQWLIEAVNASAAFGCEISDAFIQGEAGAIALAQTVVRAAETESQFKLLYPDEASLEAKLSTLAEVGYGATGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVRELVLHAGAGFITALVGNVMTMPGLGLKPGYLKIDIDAKGEIVGLG
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: CH60_LIMRD
Sequence: MAKEIKFSEDARSAMLSGVDKLADTVKTTMGPKGRNVVLEQSYGTPTITNDGVTIAKSIELENQFENMGAKLVAEVASKTNDIAGDGTTTATVLTQAIVNAGMKNVTSGANPVGIRRGIDKATEVAVEALKKMSHDVKTKDDIEQIASISAANPEVGKLIADAMEKVGHDGVITIEDSRGVDTSVDVVEGMSFDRGYMSQYMVTDNDKMEADLDNPYILITDKKISNIQDILPLLQSVVQEGRALLIIADDITGEALPTLVLNKIRGTFNVVSVKAPGFGDRRKAQLQDIAVLTGGTVISDDLGMSLKDATVDQLGQANKVTVTKDTTTIVDGAGSKEAIQERVDQIKQEIAKSTSDFDKEKLQERLAKLSGGVAVVKVGAATETELKEKKYRIEDALNATRAAVQEGFVPGGGTALINVIPALDKIEADGDELTGINIVKAALEAPVRQIAENAGVEGSVIVNELKNEKEGIGYNAADGKFEDMIKAGIVDPTMVTRSALQNAASVSALLLTTEAVVADKPDPNANNQAPAAPQGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y060_RICCN
Sequence: MSNSNYENIYKAFYCFSEATNSAYSAINTFLELPNVFNKYPAVISLIFSKTATLDSNINNIIKNGVIIYDISTALIGAINTFYKDKKLVNKILKDGQNAIDKLIETTTYLSPIVTDITNSYLVDPYKEENALLFDLQIPNSTSSDYYKLSGTESITLAEIEYY
What are the official names of this protein?
Uncharacterized protein RC0060.
Protein: EIF3L_DROYA
Sequence: MYGGDEYANNSEYYDDYAHTGDPQLDMEYERNYYAARMPDNVKYFLINFCQAIKEGNLYDIQNMYENTFPQISDHHFDKTAWPEEQEVAAIVDNDKVFLILYKELYYRHIHARISGGPKLEQRINSFFNYCDFFNLIISAQNPVMLELPDIWLWELVDEFVYQFQNFAQYRARLTDKSQDEIQQLCVNHSNEWSILCILNVLHSLVDISNIKKQLEAISQGSDPQTVAGDFGKLSFYKMLGYFSLVGLLRVHSLLGDYYQAIKVLEPIEIHKKSAYSHIPACQISTSYYVGFAYMMMRRYADAIRTFSDILLYIQRTKQLYSTRSYQNDQINKQAEQMYHLLAICLVLHPQCIDESIQQVLREKNYHDAMFKMQCGDLEVFKSFFVFACPRFVSPCPPAADAPMEDYVKDPMEHQLLVFMDEVRQQKDLPTTRSYLKLYTTLPLTKLASFIDPNASEDDVSKLLIRLLCFKHKMRNLVWSKGPSGLEGTFKSGSELDFYIDDDMIHIADTKVSHRYGDFFVRKILKFNDLNRKLKNINI
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit L, eIF3l.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit L family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATZ_ECOLU
Sequence: MKTLIARHKAGEHIGICSVCSAHPLVIEAALAFDRNSTRKVLIEATSNQVNQFGGYTCMTPADFREFVFAIADRVGFARERIILGGDHLGPNCWQQENADAAMEKSVELVKAYVRAGFSKIHLDASMSCAGDPIPLAPETVAERAAVLCFAAESVATDCQREQLSYVIGTEVPVPGGEASAIQSVHITHVEDAANTLRTHQKAFIARGLAEALTRVIAIVVQPGVEFDHSNIIHYQPQEAQPLAQWIENTRMVYEAHSTDYQTRTAYWELVRDHFAILKVGPALTFALREAIFALAQIEQELIAPENRSGCLAVIEEVMLDEPQYWKKYYRPGFNDSLLDIRYSLSDRIRYYWPHSRIKNSVETMMVNLEGMEIPLGMISQYLPKQFERIQSGELSAIPHQLIMDKIYDVLRAYRYGCAE
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of GatY.  When expressed alone, GatZ does not show any aldolase activity.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. GatZ subfamily.
Protein: GGS_NEOBT
Sequence: MAYTVEPREHSKNTTLPTVAMPPSPPSSFSASFGPFRYDTKEVNFDHWTSTKEKVVTGPYDYIAAKPGKEVRTLLLACFDEWLQVPPESLEVIGQVVRMLHTASLLIDDIQDNSELRRGKPVAQNIFGTALTINSANYVYFLALEKLNSLKNPNITDIFTEELLRLHRGQAMDLYWRDTLTCPTEEEYFEMVANMTGGLFWLMYRMMNAESSMPIDLLPVVELLGVIFQVLDDYKNLCSREYGKLKGFGEDLTEGKFSFPVIHSIRSNPEDLQLLHVLQQKSSNEHVKLYAIEIMESTGSLEYTKHVVENIVSQIQEIIYSTDEGQGRGKGILDLLHKITRLS
What is the function of this protein?
Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of aphidicolin, a specific inhibitor of eukaryotic DNA synthesis and DNA polymerase alpha (PubMed:14745177, PubMed:21897020).  The geranylgeranyl pyrophosphate synthase GGS is required for supplying a sufficient amount of geranylgeranyl diphosphate (GGDP), the general precursor of diterpenes (PubMed:21897020).  The diterpene synthase ACS then catalyzes the conversion of geranylgeranyl diphosphate to aphidicolan-16-beta-ol via the intermediate syn-copalyldiphosphate (syn-CDP) (PubMed:11457369, PubMed:21897020).  In addition to aphidicolan-16-beta-ol, the enzyme produces also low levels of amphidicol-15-ene and amphidicol-16-ene (PubMed:11457369).  The cytochrome P450 monooxygenase P450-2 then catalyzes the two-step hydroxylation from aphidicolan-16-beta-ol to 3-deoxyaphidicolin via a 17,3-deoxyaphidicolin intermediate (PubMed:21897020).  Finally, the cytochrome P450 monooxygenase P450-1 converts 3-deoxyaphidicolin to aphidicolin (PubMed:21897020).
What are the official names of this protein?
Geranylgeranyl pyrophosphate synthase, GGPP synthase, GGPPSase, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: CAPSD_MDV9
Sequence: MVSNWNRNGMKRRRTPRRGYGRPYKPVVPITRVVVHQSALLKKDEVVGCEIKPDGDVARYKMRKVMLTCTLRMPPGELVNYIIVKSSSPIANWAAAFTAPALLVKESCQDMISIIAKGKVESNGVAGTDCTKSFNKFIRLGAGISQTQHLYVVMYTSVALKVVLEHRVYIEL
What are the official names of this protein?
Capsid protein, CP, Coat protein.
What is the protein family that this protein belongs to?
Belongs to the nanoviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: Y8625_DICDI
Sequence: MKLLLLALILVLSNINLISGNGLVWPHPRLPCSPYDERGCINTQKCSSTDCDSFKRRIYFDVAYNTAFTIYQHTIFKYYSANYYKVELIVGGKVYFIHKFGQFRGDDCEFDEIIPAFYKKVQFLDLSTPIKATIQFSFDFSSHPKHANIYYSCIDVWLFDSAYYNYCPTNSGGGSGNSGGSWSSGGSGNSGGGWSSGGSGNSGGSWSSGNSGGHSTGDCPTSSGGWTSGSHSSGSWSSGGGSGSSSGGQSSGSWSSGGGSSSGGHSSGSWSSGGGSSAGGGSSSGSHSSGSWSSGGSSSGGQSSGSWSSGGGSSSGGQSSGSWSSGGGSSSGSHSSGSWSSGGSSSGSHSSGSWSSGGSSSSSGNSGWMTASGGNTGGNTGGNTGGNTGGQSSGNSGWMTASGGNTGGNTGGNTGGQSSGNSGWMTASGGNTGGNTGGNTGGQSSGSSSSGGNSGWLTSSGSNSGSSSSGSNSGWLTSSGNSVSSSSGGNSGWLTSSGGNSGGNSGSSSSGGNSGWLTSSGGNSGGSSSSGSNSGASSSGDNTGGNSGWLTSSGGNTGGNSGAATGGNSGGNSGASSSGGNSGGASSSGGNTGGNSGWLTSSGGNTGGNSGAATGGNSGGNSGASSSGGNSGWLTGGVTGGNSGGATGGNSGGATGGNSGGATGGNSGGATGGNSGGASSSGGNSGGATGGNSGGATGGNSGGATGGNSGGATGGNSGGATGGNSGGATGGNSGGASSSGGNTGGNSGGATGGNSGGATGGNSGGATGGNSGGATGGNSGGNSGASSSGGNSGWLTGGATGGNSGGATGGNSGAATGGNSGATGGNSGGNSGAATGGNIGGASSGSSSSGGNSGWLTGGATGGNSGGATGGNSGGATGGNSGGATGGNSGGATGGNSGGATGGNSGAATGANSGAATGANSGAATGANSGAATGANSGNNAAVTGAANGNNGAAAGANSGAATAANSGAATAANSGAATAANRGNNAAATGAANGNNGAAAGANSGAATAANSGAANSGAATAANSGAAAGANSGAATAANSGAATAASGGNGASGAANPGSIVTPNDQNVSPLSNSDAAATAASTTGRNPRNPTSRAPTVTPTPTSSAEEPAAGGEDSSAISKYSIQSFGIFVLSMIIYLVI
What are the official names of this protein?
Uncharacterized transmembrane protein DDB_G0289901.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: COX3_STRPU
Sequence: MAIQHPYHLVDQSPWPLDGAFSGLMMTSGNVLWFHTQKTNLTLVGFLLLITNMVNWWRDIIRKANFQGSHTAIVNKGMRYGMILFITSEVCFFFAFFWAFFHSSLAPSVEIGVAWPPSGITPLNPFLVPLLNTGVLLSSGVTLSWSHHSILAGNRTESIQALFLTVALGSYFTALQAWEYIDAPFTIADSVYGSTFFVATGFHGLQVIIGTTFLMVCLFRTAGRHFSTHHHFGFEAAAWYWHFVDVVWFVLYWLIYWWGA
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL2_SYNAS
Sequence: MAIRKYKPTSPGRRYQTCSTFEEVTTDQPQKSLLGTIKKTGGRNNFGRITSRHVGGGHKRRYRFIDFKREKLDVPGKIASIEYDPNRSARIALVSYEDGEKRYIIAPAKVAVGEKIVSGERADIKAGNAMPLRNIPVGSLIHNIELKVGKGGQLIRSAGTYGQLMAKEGSYAQVRLPSGEMRKIFIDCRATIGQVGNNEHENISVGKAGRTRWAGKRPKVRGVVMNPVDHPMGGGEGRSSGGRHPCTPWGVPTKGHKTRSNKSTDKYIVKRRG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CPTP_RAT
Sequence: MDGPERDFNLKVVLISFKKCLTDKGEVLLDHYTASWKGLVRFLNSLGAVFSFISKDVVSKLQIMEHLRSGPQSEHYISLQSMVAYEVSNKLVDRDSRSRPRHPNSGCRTVLRLHRALHWLQLFLEGLRTSSEDARTSTLCSEAYNATLAAYHSWIVRQAVNVAFHALPPRKVFLEAMNMGSSEQAVEMLGEALPFIEQVYDISQKLYAEHSLLDLP
What is the function of this protein?
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane.  Required for normal structure of the Golgi stacks.  Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0).  Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid.  Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide.  C1P transfer is stimulated by phosphatidylserine in C1P source vesicles.  Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis.
What are the official names of this protein?
Ceramide-1-phosphate transfer protein, Glycolipid transfer protein domain-containing protein 1, CPTP.
What is the protein family that this protein belongs to?
Belongs to the GLTP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Nucleus outer membrane; Peripheral membrane protein.
Protein: COBQ_METAR
Sequence: MARYLTVLGTQSHVGKSILVTALCRILKRRGYRVAPFKAQNMSNNSWITADGSEIGIAQAIQAFAAGAEPRAEMNPVLLKPKGNMTSQVVVLGKPLGDRVVGQYYESIESMMAIALNALYKLSEDYDVIVVEGAGGAAEINLYDRDIANIPLARAIHSPVLLVGDIERGGVFASLYGTIALLPPGDRELVKGLIINKFCGDPSLLGSGVGELEKLTGVPVMGIVPYSGLRIPSEDSVSLGDKKPEGLLDVDIAVVRFPLISNFTDFEALERIARVRYVSLDDSLGRPDIVILPGSKNTVSDLKMLKNSPLASEICSLASDGVPVIGICGGYQMLGRQVVDSGIEGGMPETIDGLGLLPVTTVFDRYEKCTCQSTKTVTGAGPLLAGIRGSAVTGYEIHMGQTRTDSPAFGDDGCVSDSGTILGTYLHGIFNNASFTDAVLKYACERKGLRYVRPEGVRDPYDELADIVESAIDLDAIIRLIESQDKV
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Probable cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: MUTS_STRP4
Sequence: MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTLVCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQTASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELESLISAAIAPEAPHVITDGGIIRTGFDETLDKYXCVXREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFGDDSQIDIRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLESSLQHLVNVHVATLEQDGQVTFLHKIEPGPADKSXGIHVAKIAGLPADLLARADKILXQLENQGTESPPPMRQTSAVTEHISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: VKT_PSEPC
Sequence: EDRPKFCYLPDDPGVCKAHIPRFYYNPASNKCKEFIYGGCGGNANNFETRAECRHTCVASRKGGPRRP
What is the function of this protein?
Serine protease inhibitor that weakly inhibits trypsin (Ki=0. 2 uM) (PubMed:30452896).  May have potassium channel blocking activities (PubMed:30973886).
What are the official names of this protein?
Kunitz-type serine protease inhibitor PPTI, Pseudocerastes persicus trypsin inhibitor, PPTI.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPD_BUCAI
Sequence: MSVADTIARPYAQAIFEIAIENNTIEKWKNILIFIKTIASHKKFKNFLSGSISPKYLSLIFITIGTNIIDENAKNLIKLLSENQRFNILNNIFERFVKLEACYKNIIIVQLKSAFSLKENLINKIRKVLERFFLKKTKIIYKVDPNILNGMIVKVNNTIFDLSAQNHLKQLSDSLNF
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.