PharMolix/UniProtQA huggingface dataset:
Protein: ENO_CHLP8
Sequence: MSVITKIHARQIMDSRGNPTVEVDVYTESSFGRAAVPSGASTGVHEAVELRDNDKSVFLGKGVLKAVENVNTVINSALQGMDVTEQEEIDAKLLELDGTPNKSVLGANAILGVSLACAKAGAEYSALPLYRYIGGTTAKTLPVPMMNVLNGGAHADNTVDFQEFMIMPIGFERYSDALRCGAEVFHSLKALLHKRGLSTAVGDEGGFAPNVESNEQAIELVIEAIGLAGYKAGAPTDKGGLGDGHVMIALDPASSEFYDTEKKKYVFKKSSGRELSSEEMASYWADWASRYPIISIEDGMAEDDWEGWKLLTEKIGDRVQLVGDDLFVTNSKRLGEGIEKGVGNSILIKVNQIGTLTETLQAIDLAKRNGYTSVISHRSGETEDTTIAQIAVATNAGQIKTGSMSRSDRMAKYNELLRIEEMLGDTAVYPGIKAFRV
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RBG1L_PONAB
Sequence: MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAMEEILRDSEKRQSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSQGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYKNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPIKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL
What is the function of this protein?
GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity).  Plays a role in endocytosis and intracellular protein transport.  Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells.  Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
What are the official names of this protein?
Rab GTPase-activating protein 1-like.
What are the subcellular locations of this protein?
Early endosome. Golgi apparatus. Note=Colocalizes on endosomes partially with EEA1 (By similarity). Colocalizes and cotransports on motile vesicles with ANK2 (By similarity).
Protein: SPO71_YEAST
Sequence: MDSIVNVVEDDVKYAQRVTSFSSPQNANVKVFTIPRHSFTAFRLSYVSPTELSACSQVTLLGGIPKQWYADQNNQVWKLLTKISLRKVRKQSDMLRRYGYGTIYKKRVGKIPTALYLRKHFTWSYEDNTSIHNGHRLKEAEMEMKRTRSSPVQKSEYKLSLPRRCRSSSDQNFMRQELLKEKKSELSRNNSLPLIDTAQAVDIHPVLHEEDQENTNKRNKSLLSNLKRKDLGESKSISRKDYSHFDRIPSPSSARSVGETDFNYNREPSEDTLRYPDSIIEVTNRTSPAPNSILSRSGQFVNSNDLSDGFSTSNTINNVGLNANEKIFFNALQSMEKENLMLWKTSQKYGTYLDERRKSADAFQKRERGSCVDIGKLHSSHLPFINILPPWPTELTEEERIIHDRLASKHSHHIRKHVHNARNKTSCKIKDSVGTFLGMTNSLTNKATVKKRTGQILKKEKMLVMVKEAIQNKVPLPNFSENECFDTRVSERWKEYIVIARSTGRFDPPILLQFYRHRHIPEIEDISSIATKYHRNPLDFFLSRNCIVKFYSSLDKTISIQKPDKRLGGFIDESIEKKDELKHYSPIKIFILRCSSIRSSGRWYKFLLESLDRQLFTPAINLKIPLTEISIKINLNEIIFQKLIDLGKQEKDRLKICFLQRGYKIFQHPILRYFTVAILEKLKLAHYDYLIRKWDTENPVLGCALKRYDRLEWIPCDEDSLVTGIFAFCQSHLIQYRPIANRLRETKSLEGKCLKEPTPIEGFLIRLTDKYGSARTNFGKYSISTAYFFTCENLLFSMKAYRANPPLPIDSMIDDTSTEIEKEEIWKQWKKIPEVYEQQPYPLDTNDHIEWMNCQTTQSEYDSRDFYAFHCFHRRIDQILKTDNVIDLTEVKDIYQGTRTDYEADKIKYGVYKEASEIFWHRNYEIDDVSRSVINIETSNGLLLKLLATSATVAEEWVIKLKQMISYWKNKQREDTERLLKIRRSNAGLLMLNGEEETKIGENTLRWIVEHGRADEQTFNANGISLSRPLIQKGPLYQKPHKHSVFSKYYVVLISGFIVLFHCFHRSTTGFAKEVLEYAHYVTIPIDDCYLYSGTTTELDLLQRDRTFDEINYGSHALPRVYGDGWRSVEDESSRCFTLWFGTRRALSSNRLQKKGNEKQYTQDYGRQDNNIDPPSAPEADLNNSNVPSNTDKIHFTKKLGVSGKSMVFMARSRQERDLWVMSIYYELERLRRTASTSNSRNQTM
What is the function of this protein?
Recruits the lipid transfer protein VPS13 to the prospore membrane during sporulation, thereby aiding prospore membrane formation.
What are the official names of this protein?
Prospore membrane adapter protein SPO71, Sporulation-specific protein 71.
What is the protein family that this protein belongs to?
Belongs to the SPO71 family.
What are the subcellular locations of this protein?
Prospore membrane; Peripheral membrane protein.
Protein: RS15_ANADE
Sequence: MALVQEKKQELVQKYKRHEKDTGSPEVQVALLSERIAYLTEHFKTHKKDHHSRRGLLKLVGQRRRLLDYLRTIDQGRYKTLIDQLGIRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ARNA_KLEP3
Sequence: MKAVVFAYHDMGCTGIQSLLDAGYDIAAIFTHPDNPGENHFFGSVARLAAEQGIPVWAPEDVNHPLWIERIREMKPDVLFSFYYRNLLGDEILNLAPKGAFNLHGSLLPKYRGRAPLNWVLVNGESETGVTLHRMVNRADAGDIVAQQTVAIGPDDAALTLHRKLCAAATELLGQALPAILEGKTAERPQDHSQATYVGRRTPEDGRLDWEQPAQTLHNLVRAVSDPWPGAFGYAGANKFIVWKSRVRHDLPAAKPGTVISVAPLIVACQDGALEIVTGQTERGVYMQGAQLAQALGLVSGAVISSKPVVAIKRRTRVLILGVNGFIGNHLTERLLQDDNYEIYGLDIGSDAISRFLESPRFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLKIIRDCVKYNKRIIFPSTSEVYGMCTDKNFDEDTSNLVVGPINKQRWIYSVSKQLLDRVIWAYGDKYDLKFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLIEGGKQKRCFTDISDGIEALFRIIENKDGRCDGQIINIGNPENEASIKELAEMLLACFERHPLRDRFPPFAGFREVESSDYYGKGYQDVEHRKPSIRNAKRCLNWEPKVEMEETVEHTLDFFLRTVELVDDKNP
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: PG081_VAR67
Sequence: MADAITVLTAIGITVLMLLMVISGTAMIVKELNPNDIFTMQSLKFNRAVTIFKYIGLFIYIPGTIILYATYIKSLLMKS
What is the function of this protein?
Envelope protein.
What are the official names of this protein?
Protein OPG081, Protein I5.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG081 family.
Protein: ISPF_YERPB
Sequence: MRIGHGFDVHKFGENGSGPLIIGGVRIPYEKGLLAHSDGDVALHAATDALLGAAALGDIGKLFPDTDPAFKGADSRGLLREAYRCILAKGYKLGNLDITIIAQAPKMAPHIPQMRVNLAEDLQCHMDDINVKATTTEQLGFTGRGEGIACEAVVLLVNVEQG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RL30_THIDA
Sequence: MSEQKKIKVTLVKSLIGTKAPHRACVRGLGLRRMHHTVEVLDTPENRGMITKVAYLVKCEA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: LYS1_EMENI
Sequence: MGSNKIWLRAETKPAEARSALTPTTCKALIDAGYEVTVERSTQRIFDDDEFAKVGAPLVEEGSWVKDAPKDAYILGLKELPEDDFPLEHVHISFAHCYKEQAGWEKVLSRWPRGGGVLLDLEFLTDDAGRRVAAFGFSAGYAGAALAVKNWAWQLTHPEGEPLAGEKPYANQDLLIQSVKESLQAGQKQSGKSPKILVIGALGRCGKGAVQLAKDVGIPESDIIQWDMEETKKGGPFKEIVEDADIFVNCIYLSSKIPHFVNVESLSTPSRRLSVICDVSADTTNPNNPIPVYNITTTFDKPTVPVTLPNGTQGTPLSVISIDHLPSLLPRESSEMFSEALMPSLLQLKDRENARVWKQAEDLFNQKVATLPQTA
What is the function of this protein?
Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.
What are the official names of this protein?
Saccharopine dehydrogenase [NAD(+), L-lysine-forming], SDH, Lysine--2-oxoglutarate reductase.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
Protein: ACM1_PIG
Sequence: MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPAKQPPRSSPNTVKRPTRKGRERAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFIVTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is Pi turnover.
What are the official names of this protein?
Muscarinic acetylcholine receptor M1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: SYL_PETMO
Sequence: MEKTYNPQEIERKWQRNWQEKDAFKVSNEEYHKKYYDLVMFPYPSGTLHVGHVKNYVIGDVIARYKRMRGYNVMHPFGFDAFGLPAENAAIEKGNIHPEDWTMQNINIIRNQIKKLGISYNWEREVITCKEDYYKWTQWIFLQLYKNGLAYKKKAPVNWCPNCKTVLANEQVVNGKCERCGTVVEIKQLEQWYFKITDYAEKLLYDLEKLSGWPENVKIMQKNWIGKSVGAEVEFNLDNGKGSLRVFTTRPDTLWGVTFMALAPESPLVEELTTPENSEKVNQFLQRVSLQDRFKRTAEGAEKEGVFTGSYAINPVNGEKIPIYVANYILYEYGTGAIMAVPAHDQRDFEFAKKYDLPIRIVIMPEGDELTEENLEKAYIGEGVLVNSGEFTGLDNQTAIREVSQWLEDKKIGKVVTQYKLRDWLISRQRYWGAPIPVVYCEKCGVVPVPEKDLPVKLPRDVAFEPTGKSPLIDHPDFKETTCPKCGGKAKREVDTMDTFVDSSWYYLRYVNPKLEDKPFNKEDVDNWLPVDQYIGGVEHAILHLLYSRFITKVLKDLGYVSFDEPFKNLFTQGMIYRNGAKMSKSKGNVVSPEEMIEKYGTDALRTYILFMAPPERDAEWNDSGIEGTYRFLNKVWNTYMKIQDKIIHLENKPNYPLKNKSEKDLRRKLHQTIEKITSDIEGNFQFNTAVSSLMELLNELNSYLNNTDDKDWNLNLLKEFSEDFVLMLSPIAPHISEELWKNFGKDEFIFKASWPEIDKNALKAEEITLAVQINGKLRAQITVDVSLNEDEVKSYALEDDKVQKYISGKKIQKIIYVPKKIINIVVK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AC4CH_YERPY
Sequence: MNREITFFGRFEADILADRKTITIRDSSESDFRSGEVLRVCRNEDGVFFCHIKVKSVTPVTLDGLSERHAEQENMSLDELKKVIKAIYPGLDRFYVIEFTRC
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: GLGA_YERPS
Sequence: MRVLHVCSELFPLLKTGGLADVIGALPAAQLAEGADVRIILPAFPDLRRGIPETVLVREIDTFAGRVALRYGHYRGIGIYLIDAPALYDRAGSPYHDASLYAYSDNYLRFALLGWMACELACGLDGYWRPEVVHAHDWHAGLTCAYLAARGRPARSVFTVHNLAYQGLFSADHLSELHLPAEFFQIYGLEFYGQISYLKAGLFFADHVTTVSPTYAKEITQPAFGYGMEGLLQALARQGRLTGILNGVDSDIWDPQSDTLLPTRYDAENLQAKAINKTHLQTAMGLQLAENKPIFAVVSRLTVQKGLDLVLEALPELLALGGQLVVLGSGDATLQEAFLAAAAEHSGQVGVQIGYHEAFSHRIIAGSDVILVPSRFEPCGLTQLYGLKYGTLPLVRHTGGLADTVVDCALENLADGSASGFVFNECEAQALVKAIRRAFVLWSRPKHWRHVQRHAMRLDFGWQLAAVDYLSLYRRL
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: ZAPD_BURMA
Sequence: MILYEYPFNERIRTLLRLEDLFERFTFFVAQEDAREHHVALTTLFEISEVAGRADLKSDLMKELERQRQTLAPFRGNPGIEQNALEAVLGEIEQTLANLAQMQGKTGQHLIDNEWLASIRSRAVIPGGTCKFDLPSYYAWQQWPAEQRRHDIAKWAMPLLPLRDAAMIVLRLARESGQASKVMAMQGSYQQMLSGRTYQLMQVRVPPELRVIPEASANKYMLWVRFTAQDGDVRPRAVDIDVPFQLTLCNL
What is the function of this protein?
Cell division factor that enhances FtsZ-ring assembly.  Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
What are the official names of this protein?
Cell division protein ZapD, Z ring-associated protein D.
What is the protein family that this protein belongs to?
Belongs to the ZapD family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to mid-cell in an FtsZ-dependent manner.
Protein: CAPS1_SPV1
Sequence: MSESVTQQVFNFAVTKSQPFGGYVYSTNLTASTSSAVTSTQLTPLNLSITLGQITLSGNSLVIPATQIWYLTDAYVSVPDYTNITNGAEADGVILIYKDGVKLMLTTPLISSMSISNPARTHLAQAVKYSPQSILTMYFNPTKPATASTSYPNTVYFTVVVVDFSYAQNPARAVVSANAVM
What is the function of this protein?
VP4 self-assembles to form, together with capsid protein VP10, an icosahedral caspid of 87 nm in diameter, with a T=43 symmetry and composed of 420 hexamers and 12 pentamers (PubMed:31636205).  VP4 proteins arrange into hexons, while VP10 proteins form the pentameric densities located at the 5-fold axes in the virion (PubMed:31636205).  The stoichiometry of VP4:VP10 is 42:1 (PubMed:31636205).
What are the official names of this protein?
Capsid protein VP4.
What are the subcellular locations of this protein?
Virion.
Protein: RUSA_BPHK7
Sequence: MNEYQFVLPYPPSLNTYWRRRGSQYYISDKGQKYRKDVQQIIRQLKLDIFTKSRLRIKVIADVPDSRRRDLDNILKGLLDSLIHAGFAEDDEQFDDIRVIRGVKVPGGRLGIKITELESV
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates.  Promotes DNA repair.  Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease rusA, Gp67, Holliday junction nuclease rusA, Holliday junction resolvase.
What is the protein family that this protein belongs to?
Belongs to the RusA family.
Protein: BGAL1_ORYSJ
Sequence: MMGRRGSSWCRWWVALLVLAVAADAVGCTSVSYDDRSLVIDGQRRIILSGSIHYPRSTPEMWPDLIKKAKEGGLDAIETYIFWNGHEPHRRQYNFEGNYDVVRFFKEIQNAGMYAILRIGPYICGEWNYGGLPAWLRDIPGMQFRLHNEPFENEMETFTTLIVNKMKDSKMFAEQGGPIILAQIENEYGNIMGKLNNNQSASEYIHWCADMANKQNVGVPWIMCQQDDDVPHNVVNTCNGFYCHDWFPNRTGIPKIWTENWTGWFKAWDKPDFHRSAEDIAFAVAMFFQKRGSLQNYYMYHGGTNFGRTSGGPYITTSYDYDAPLDEYGNLRQPKYGHLKELHSVLKSMEKTLVHGEYFDTNYGDNITVTKYTLDSSSACFINNRFDDKDVNVTLDGATHLLPAWSVSILPDCKTVAFNSAKIKTQTSVMVKKPNTAEQEQESLKWSWMPENLSPFMTDEKGNFRKNELLEQIVTSTDQSDYLWYRTSLNHKGEGSYKLYVNTTGHELYAFVNGKLIGKNHSADGDFVFQLESPVKLHDGKNYISLLSATVGLKNYGPSFEKMPTGIVGGPVKLIDSNGTAIDLSNSSWSYKAGLASEYRQIHLDKPGYKWNGNNGTIPINRPFTWYKATFEAPSGEDAVVVDLLGLNKGVAWVNGNNLGRYWPSYTAAEMAGCHRCDYRGAFQAEGDGTRCLTGCGEPSQRYYHVPRSFLAAGEPNTLLLFEEAGGDPSGVALRTVVPGAVCTSGEAGDAVTLSCGGGHAVSSVDVASFGVGRGRCGGYEGGCESKAAYEAFTAACVGKESCTVEITGAFAGAGCLSGVLTVQATC
What are the official names of this protein?
Beta-galactosidase 1, Lactase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: SEC62_MOUSE
Sequence: MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVECLLDSKWAKAKKGEDALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDVKKEKDKGKSESGKEDDKKSKKESVKEEKTKKEKEKKKDGEKEDSKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVFVWIYDPVHIKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAIARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKGAPADHGPEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCDEEDDDKDGEVPKSAHEKS
What is the function of this protein?
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER).  Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides.  Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
What are the official names of this protein?
Translocation protein SEC62, Translocation protein 1, TP-1.
What is the protein family that this protein belongs to?
Belongs to the SEC62 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ATG16_XENTR
Sequence: MAAGCRGPACPSWRLHISRELRRRDREQRQVFEELISQYKRLLEKSDLQSVLADKLQAEKYEQQSRHDSSPGPDGMRNDMLLQDMAQMRIKHQEELTELHKKRGELAQTVIELNNQMQQKDKEIQANEEKIAKYLQTIQDLETECQDLRNKLQELERANQTLKDEYDALQITFTALEDKLRKTTEDNQELVSRWMAEKAQEANRLNAENEKDSKRRQARLQKELAEAAKEPLSFEHDDDIEVLNDNADPVGDSAGAQATGRNISKRNSQPAVGGLLDSITNIFGLSESPSLSHRSDSSRRRSLNSFPASPDCADTPGAGNREVRVPATAVYSFDAHDGEVNAVRFSPGSRLLATGGMDRRVKLWDVIGNKCEAKGSLTGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRTECIVRELELQGRITALDLNPERTQLLSCSRDDLIKITDLRANAVQQTFSAPGFKCGSDWTRVIFSPDGSYVSAGSAEGTLYFWNVLTGKVERMFSKQHSSSINAVAWSPSGTHVVSVDKGSRGVLWSDF
What is the function of this protein?
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II.  Thereby, controls the elongation of the nascent autophagosomal membrane.
What are the official names of this protein?
Autophagy-related protein 16, APG16-like 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ATG16 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5.
Protein: RUP2_ARATH
Sequence: MNTLHPHKQQQEQAQQQEEARYEWDLSLSTVVSSSSSSASDVIGAIEFDPTDNIVATAGISRKIRFYGLPSLLRNNAVSGTGVSFVDQATACEYYICTPAKLSSLRWRPGSGGRVIGSGDYDGVVMEYDLEKRTPVFERDEHGGRRVWSVDYTRHGGASTVGASGSDDGTMQVWDPRCPPEESVGVVRPAGICRSAVCCVEFDPSGGPAVAVGCADRKGYVYDIRKLVDPALTLQGHTKTVSYVRFLDGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHVNNRNFVGLSVWRNGALFGCGSENNRVFVYDRRWGKPVWVDGFEPVGMNSGSDKRFVSSVCWRQSGVDQCTLVAGGSDGVLQVYVGKRKP
What is the function of this protein?
Functions in association with RUP1 as repressor of UV-B-induced photomorphogenesis mediated by UVR8 and HY5.  Plays a crucial negative feedback regulatory role downstream of UVR8-COP1 to inhibit UVR8 function, balance UV-B-specific responses and ensure normal plant growth.  Is involved in the regulation of photoperiodic flowering and vegetative development.  May act as negative regulator of photoperiodic flowering by suppressing flowering through the action of CONSTANS (CO) and FLOWERING LOCUS T (FT).
What are the official names of this protein?
WD repeat-containing protein RUP2, Protein EARLY FLOWERING BY OVEREXPRESSION 2, Protein REPRESSOR OF UV-B PHOTOMORPHOGENESIS 2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: NRAM_I34A0
Sequence: MNPNQKIITIGSICMGIGIISLILQIGNIISMWVSHSIQTENQNHHEACNPSIAGQDAASVALAGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRTLMSCPVGEAPSPYNSRFVSVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITDTIKSWKNNILRTQESECACINGSCFTIMTDGPSNGQASYKIFKIEKGKVVKSSELNAPNYHYEECSCYPDAGEVMCVCRDNWHGSNRPWVSFNKNLDYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGAYGIKGFSFKYGNGVWIGRTKSTSSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPNHNTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: RSMA_SHEPW
Sequence: MSNKVHLGHTARKRFGQNFLTDENVINRIVGAISPDNEHVMVEIGPGLAALTEPVASGIDKLTVVELDKDLVERLKTHPTLKDKLEIHQGDALNFDFKQLVREDMQMKVFGNLPYNISTPLMFHLFEFAQYIENMHFMLQKEVVLRLSASPGTKAYGRLTVMAQYHCQVMPVLEVPPGCFTPPPKVDSAVVRLVPYKTKPFPCKDVEVLRHLTTTAFNMRRKTLRNNLKHMLSDDEFAQLEIDSTLRPEQISVQQYVAMANLFIDKQTKS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.