PharMolix/UniProtQA huggingface dataset:
Protein: ATPG_DESVH
Sequence: MPSLKDVKVKIAGVKKTKQITKAMNMVASAKLRGAQQRIERFRPYAEKFYGMLGDLASKADGSAHPLLEVRDEIKTCGIVLATSDRGLCGSFNANLISTALKLAKQKAAEGKTVKFYCVGKKGRDTIRKADFEVVTAIADQMGSFDFQLANKLGLEVINHYLTGELDEVVLVYGEFVSTAKQLPITLPILPIASEKKDEAEAAPSKEYIYEPAVEGLLAELLPRFIKVQIYRGLLDTSASEHAARMAAMDNATRSCDDMIGALTLLFNKTRQASITRDLMDIVGGAEALKG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL29_SHEAM
Sequence: MKASELREKSVEELNAELLGLLREQFNLRMQHATGQLAQTHQLKQVRRNIARVKTIITSKAGA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: Y809_CLOBK
Sequence: MKNKKALFIPLFIIILFIAFFNKIINFIINIKWFKEVNYLAVYFTKMRAIIILMIPIFIIFFISIWMYYKSLIINKNKSVVDIGLNKNNYGKKLFFIFNFIVSIFLAYIFSSSYWYRILQFNNSVDFNVKDPIFFKDVSFYIFKLPLFESLYKVIISLLLFLVITTFIAYFILEAKYKIQSRKDINLKNINYGIKSFAGKQLAIVSGLIILFISFGHLIKIWNLVYSSNGVSFGASYTDVHATLLFYKIIVVITLISSIVTLLSIVKGKFKPVSICIGITIFLIVSQNIASFLVQNFIVKSNEKTLEQPYIKNNIDLTRKAFALDDIEIRDFDIKNDLQKQDIADNKASIDNIRINSFKPTLEFYNQVQIIRYYYTFNDIDIDRYNINGKYNQVFLAAREIDTDALNPNTWQNRHLIYTHGFGAVMNKVNSVTSEGQPDFVIKDIPPYNKTNIKLTNPRIYFGEKTNDYVIVNTKINEFDYPREDSNKTNKYNGHAGIKMSFINRLLFAINKKDINFLLSKDIKKDSKIIINRNIVERAKKIAPFLTYDSDPYMVIYNGKIYWIIDAYTTTNRYPYSEPYDSINYIRNSAKVVIDSVDGDTNFYITDKKDPIVNNYAKTFKGLFKEEEDAPKEIREHFRYPKDLFSIQSKVLGKYHVKDPGVFYNGEDLWEVSKDQKHVEGETNTNDAPYIIMKLPDQNKEEMVLLNYFNVMKKDNMIALFGARMDGEQYGKKILYKLPSDKTVYSPYLFKQKINQDTNISKELSLWNREGSKVQYGDTIILPIKNSLLYIEPLYLRASGKNSIPEMKRVILSYNDKLVLSSSIQEGIKEIFNSKDNKINDKNEKDSTKTIDDSKLKKAQEYYNKAIEAQKNGDWTKYGENINELGNILNSIK
What are the official names of this protein?
UPF0182 protein CLD_0809.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL21_PROMP
Sequence: MTSSKKPSNSSAKNENLYAIAETSGQQFWFEVDKYYDIDRLNAKEKDKITIDKILLIKDKDNISLGQPYVKNAKIELEVVSHKRDKKIIVYKMRPKKKTRRKMGHRQELTRVMVKSISITNSTPKTSSKTEVKKKSTSPKASNPEN
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: LEU3_CLAMS
Sequence: MPRTISLAVVPGDGIGPEVVHEALRVLREAVPADVSLDTTQYPFGAGHFLETGQILTDSDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVASPLAAPGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFAFELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDPSRFDVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADPTAAILSVALLLDHLGLSEAAARVSAAVSDDLAARATGDAAPRSTAEVGDAILRALSTNH
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_SOLUE
Sequence: MARLAGVDLPPGKRAEIGLTYIYGIGRTRSKSLLHRAGIDFDKKIRDLTEDEINKVRTILEEEGAVEGDLRKEISMNIKRHIEMGSYRGLRHRRSLPVRGQRTHTNARTRKGPRRGTVANKKKATGKT
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SCC13_ARATH
Sequence: MFYSHTLLARKGPLGTVWCAAHVHQRLKKSQYTSINIPDTVDNIMFPEVPLALRTSSHLLVGVVRIYSKKVDYLYNDWNLLNTWVAKAFVSTQVNLPEDARQAPPESVTLPQALNLDEFDLEDDTLDMEFDNHTRSEEDITLTDQIPTGIDPYVAVTFDEDIISESIPMDVDQSTEPVSRHTGEIDVETAHETGPDNEPRDSNIAFDTGTYSPRNVTEEFTEVQDPRQSNLTEERIPNSERNDATSPGTVPEIERMRDAAHDLSPTSHPSFAAQQQDVRVERTESLDETLNEKEPTIPSIDEEMLNSGRHSAFELRSGSPGSAAGSEEERADFVHPSPQLVLQPSPPPQPQRRARKRKNFDGVTVLTNKNISERLKDPSDTLRKRKKMPSSKLKFWRMNNQSRKDQNFNEPLFTGFSDDLRNVFEKDYVASKPHLAVSDETLPEPASVSPTREAEVEINPVSPIPDSTNPDSTVQLSPAQQTEDVLDSAGPRPAHAESVATEAQSPRTFDNDDMGIEHLRDGGFPVYMPSPPPRSSPFRTDDFTTQSGNWETESYRTEPSTSTVPEDLPGQRNLGLSPVSERTDEELYFLEVGGNSPVGTPASQDSAALTGRARALAQYLKQRSSSSPTTSSHPSGDLSLSEILAGKTRKLAARMFFETLVLKSRGLIDMQQDRPYGDIALKLMPALFSKVQT
What is the function of this protein?
May be involved in sister chromatid cohesion during mitosis.
What are the official names of this protein?
Sister chromatid cohesion 1 protein 3, SCC1 homolog 3, AtRAD21-2.
What is the protein family that this protein belongs to?
Belongs to the rad21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BFR_SYNY3
Sequence: MKGKPAVLAQLHKLLRGELAARDQYFIHSRMYQDWGLEKLYSRIDHEMQDETAHASLLIERILFLEETPDLSQQDPIRVGKTVPEMLQYDLDYEYEVIANLKEAMAVCEQEQDYQSRDLLLKILADTEEDHAYWLEKQLGLIEKIGLQNYLQSQMS
What is the function of this protein?
Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.
What are the official names of this protein?
Bacterioferritin, BFR.
What is the protein family that this protein belongs to?
Belongs to the bacterioferritin family.
Protein: SUMO3_ARATH
Sequence: MSNPQDDKPIDQEQEAHVILKVKSQDGDEVLFKNKKSAPLKKLMYVYCDRRGLKLDAFAFIFNGARIGGLETPDELDMEDGDVIDACRAMSGGLRANQRQWSYMLFDHNGL
What is the function of this protein?
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer.  Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (By similarity).
What are the official names of this protein?
Small ubiquitin-related modifier 3, AtSUMO3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: NCAP_I68A2
Sequence: MASQGTKRSYEQMETDGERPNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELVLYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACNSAAFEDLRVLSFIRGTKVSPRGKLSTRGVQIASNENMDTMGSSTLELRSRYWAIRTRSGGNTTQQRASAGQISVQPTFSVQRNLPFDKPTIMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEMSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: CBX3_HUMAN
Sequence: MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ
What is the function of this protein?
Seems to be involved in transcriptional silencing in heterochromatin-like complexes.  Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.  May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR).  Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.  Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.  Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).
What are the official names of this protein?
Chromobox protein homolog 3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein.
Protein: PDRP_THEPX
Sequence: MEEGVSIYLVSDSNVDTAENIASIAAAHFDTFIEKIKKYPYVGDKNQIEEIIMEAANDANSIIIHTMVVPELKDYLLKKAQKFGIKIVDVMGPVINAIEDSTGISPHTNLAKNNKEDYLKKIEVIEFAVKYDDGKDAMGILLADVVVIGVSRTSKTPLCMYLAHKYIKAANLPLVPEIEPPQELFEINPKKIFGLTIDPEVLVKIRKERLKSLGLDANAIYATEERVKKEIKYAEEVMKRLGCTVIDVTNKAVEETANVILNVLKGGEIS
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: ALLA3_DELRA
Sequence: VERYAFGL
What is the function of this protein?
May act as a neurotransmitter or neuromodulator.
What are the official names of this protein?
Allatostatin-A3, AST-A3, VERYAFGL-amide.
What is the protein family that this protein belongs to?
Belongs to the allatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ERA_STAA9
Sequence: MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFIDTPGIHKPKHKLGDYMMKVAKNTLSEIDAIMFMVNANEEIGRGDEYIIEMLKNVKTPVFLVLNKIDLVHPDELMPKIEEYQSYMDFTEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDDQISDHPEQFVVGEIIREKILHLTSEEIPHAIGVNVDRMVKESEDRVHIEATIYVERDSQKGIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: FADI_SHISS
Sequence: MGQVLPLVTRQGDRIAIVSGLRTPFARQATAFHGIPAVDLGKMVVGELLARSEIPAEVIEQLVFGQVVQMPEAPNIAREIVLGTGMNVHTDAYSVSRACATSFQAVANVAESLMAGTIRAGIAGGADSSSVLPIGVSKKLARVLVDVNKARTMSQRLKLFSRLRLCDLMPVPPAVAEYSTGLRMGDTAEQMAKTYGITREQQDALAHRSHQRAAQAWSDGKLKEEVMTAFIPPYKQPLVEDNNIRGNSSLADYAKLRPAFDRKHGTVTAANSTPLTDGAAAVILMTESRAKELGLVPLGYLRSYAFTAIDVWQDMLLGPAWSTPLALERAGLTMSELTLIDMHEAFAAQTLANIQLLGSERFAREVLGRAHATGEVDDSKFNVLGGSIAYGHPFAATGARMITQTLHELRRRGGGFGLVTACAAGGLGAAMVLEAE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNB_BUCAP
Sequence: MFQNNPLLAQLKKNLHAKTPRVEGIVKSTERGFGFLEVDAQKSYFIPPKNMKNVMHGDKISAVLKIEKDREIAEPEKLIEPFLNRFVGKIEKKDNKLFIFPDYPFLKDFIACRPKKSCVHVFQTGDWAVAKLIQHKLNGNHIFYAELIEEIVKANNPLIPWWVTLSRHNLERKEPKIEKDDLILKNNSHREDLTHLNFITIDNFNTKDIDDALFIEEIHNGNLRLIVAIADPTSYIKSGSKLDITAAKRGFTNYLPGFNVPMLPRSLSEDICSLNPHERRPVLACCITILKDGNICSKINFFLAWIKSKSKLSYDNVSDWIEKKSSWKPETKSIENQILLLHRLCLLRIKWRTSNAVLFQDSLEYRFQFSETGIVEDVVIEKRRIAHKIIEESMIIANISAANFLSKNLGFGIYNTHAGFDPINAENVVSFLNNYNLKFTVKEITTLKGFCNLRRVLNILSDNYINSRIRRYQSFGDFSITPSPHFALGLVEYATWTSPIRKYSDMINHRLLKSIINQDTNITKPSEDIKLKISEQKRRNRIAERDISDWLYTLLLQKKEFKNKKFNAEIIDVSRSGIRAKLLENGANVFIPALFLHPIREELVFNQETGKVFIKGVLYYKISDLITVVLSEIRLQTRSIIARIDH
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity).
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_OLEA2
Sequence: MPYTPHTPEEIRQMLDVIGVKSIDDLFAEIPPEMQPRSFDIPEGMSEMEVCARIQRMAAKNRIDLVSYLGAGFYDHHIPKAVDNLVSRGEFYTAYTPYQPEASQGTLQAIFEYQTAVCRLMEMEVANASVYDGGSAIFEAMMMAARATRRSKLVIDEALSPIYRTMLASYTSNLNMELVTVAHNEGRSDKQALMDAVDDKCAAVVVQNPNFFGAVDDFTELFTHARSCNALGVISVYPVMQSVLKTPGEMGADIAVADGQSLGMPLSFGGPYLGIMTCTKKLARQIPGRIAGRTKDVDGKTGYVLTLQAREQHIRRAKATSNICSNQALCALRAIIHMCLTGPEGLVRTAELSMERAHYAADRLTALPGVSLLHDAPFCNEFALRLPVSAYDVVDRLVNHGVVPGFPLGGYYAGMDDVLLVACTEKHSFEQIGIMAELVGGML
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: MUTS_SYNE7
Sequence: MTTSELPEHLAKHEVRYADHRQVERDRLTPMMQHYAEVKDQHLQQILLYRMGDFFECFFQDAIVVARELELVLTSKEAGKEVGRVPMAGIPYHALDRYASQLVEKGYAIAICDQVETAAQAQGPLVRREITRIITPGTILEEGMLQARRNNFLAAVVIAGEHWGLAYADSSTGDYWTSQSTGLEGLTQELYRLQPSEVLFPSAAPDLAGLLRPGQSKPQQIPDCLPDSFCYALRSPMPFELHEARQRLLEHFQLRSLEGCGCEQLPLAIRAAGGLLDYLGETQRESLAPLQKPRTYSLSEFLILDQQTRRNLEITQTQRDGSFHGSLLWALDRTMTSMGGRLLRRWLLQPLLNPEAIRNRQAAIQELCQDGRLRQDLRSLLQKIYDLERLSGRAGAGTANARDLLALAESLLRLPELAQLLSRAQSPLLAQLQQVPPELEQLGDRLQQHLVESPPLQLTEGGLIRSGVAIALDELRQQVESDRQWIASLEASERTATGINSLKVGYSKTFGYFISLSRSKADQVPDHYIRRQTLTNEERFITPDLKERESRILNAQTDLNQLEYDLFVGLRSEVSHHVETIRAIATAVAAADVLAALAEVAVYQNYCCPEIRDDRQLAIQDGRHPVVEQALPSGFYVPNSCGLGSDRGPDLIVLTGPNASGKSCYLRQVGLIQLLAQIGSFVPAKNAQVGICDRIFTRVGAVDDLATGQSTFMVEMNETANILNHATARSLVLLDEIGRGTATFDGLSIAWAVAEYLAREIQARTIFATHYHELNELSGLLKNVANFQVTVKELPDRIVFLHQVQPGGADRSYGIEAARLAGLPSEVIDRAREVMSRIEKHSRIAVGLRRGNGSQRRTQASPQQIDATIATEQLGLFSGPSH
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: BGLFU_BIFBR
Sequence: MTMIFPKGFMFGTATAAYQIEGAVAEGGRTPSIWDTFSHTGHTLNGDTGDVADDFYHRWEDDLKLLRDLGVNAYRFSIGIPRVIPTPDGKPNQEGLDFYSRIVDRLLEYGIAPIVTLYHWDLPQYMASGDGREGGWLERETAYRIADYAGIVAKCLGDRVHTYTTLNEPWCSAHLSYGGTEHAPGLGAGPLAFRAAHHLNLAHGLMCEAVRAEAGAKPGLSVTLNLQICRGDADAVHRVDLIGNRVFLDPMLRGRYPDELFSITKGICDWGFVCDGDLDLIHQPIDVLGLNYYSTNLVKMSDRPQFPQSTEASTAPGASDVDWLPTAGPHTEMGWNIDPDALYETLVRLNDNYPGMPLVVTENGMACPDKVEVGTDGVKMVHDNDRIDYLRRHLEAVYRAIEEGTDVRGYFAWSLMDNFEWAFGYSKRFGLTYVDYESQERVKKDSFDWYRRFIADHSAR
What is the function of this protein?
Bifunctional beta-D-glucosidase/beta-D-fucosidase.  Activity towards pNP-beta-D-fucoside is about 80-85% of the activity towards pNP-beta-D-glucoside.  Also has slight activity (less than 10%) towards pNP-beta-D-galactoside, and very low activity (less than 1%) towards pNP-beta-D-xyloside.  Hydrolyzes laminaribiose, sophorose, cellobiose and gentobiose.  Not active against maltose, pNP-alpha-D-glucoside or pNP-beta-L-fucoside.
What are the official names of this protein?
Bifunctional beta-D-glucosidase/beta-D-fucosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPA_SYNR3
Sequence: MQKPEWLRVKAPQRERIGAVADLLLDLKLNTVCQEASCPNIGECFAGGTATFLIMGPGCTRACPYCDIDFDKSVRELDPTEPERLGEATQRLGLKHVVITSVNRDDLADGGASQFVACIEQIRRRSPGTTIELLVPDFCGDWDALAAVMAGAPDVLNHNIETVPRLYKKARPQAIYERSLELLQRVRQGWPRCYSKSGLMVGLGETDAEVIEVLADLRRHAVDIVTIGQYLSPGPKHLPVDRFVSPEQFEQFRSQGESELGFLQVVSTPLTRSSYHAGEVQRLMQEHPR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRK_THEP3
Sequence: MDKIPVETLIKDLNLEVIVEAKNNKIDITTSDVNRPGLQFSGFYEHFAYERVQIIGKVETTFIEQLPDDVLAERADRFFNYPIPCLIVTRDLNIRQEIIDAAQKHDRYLLRTKEASTKFINRLINYLDEKLAPQITIHGDLVDVYGIGVLLLGESGIGKSETALELIKRGHRLVADDAVEISKISEDKLQGSSPEIIRHFIEIRGIGILDIKTLYGVGSVRNSMNIDLVIQLEEWDEDKYYDRLGLEDDYIKFLDVKVPKLTIPVRPGRNLAIIVEVAAMNHRQKQMGYNAAHELNKKLLKQIGN
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: F227B_RAT
Sequence: MELPTPQKVQEPPKSFEEFLKSQNWDYWPRDVHIRDGDIWENTLRKLEEAVSYNSVYSYLWTNVPRLYEIVDSMESKLKECSHLLQQHASRLFESDRLISKKRTYTNLDRYKAFLKEHYRRKKIVLSDQMETEKNIEGCTFLLKQNELTQLPRHLDAKQIYLYVLRTHNLEEKVFKVWKTHILSDCSIALLHDCFWWWFLHKFKPDKRDQDWLFDRIAESYVTLFMRIPLRRKDIFFQMYPDWLAQAVYTTFQESFPESCSLFNDNFKEDLGNTIFLWLSGLKPAPGFWTHWKLQDLCTTTIHGCRRVPVKLRRGIMSSQEHTSATVGLKIEDILKNPRALPVLKEESAASKVTTKSHYRSLGPEFYKVLFDFGGQSPLILYYLKMHELGGISVTYNPKGSKFTKILREPPPAPTYCEIIKDAKRKFADNKKDFKRVKQRIKDDIKFLKEQQEQIDKELDRLQAKASKNLQEVKNDFENFLHKLRVEAKLKEEYRGSASPSESLQSLQSPNSSLSSPAMSEDFNSVEEGGLKEARSDHYLRTTHSSFSSINLIGGECTTKSTFCCSSLKSSHQ
What are the official names of this protein?
Protein FAM227B.
What is the protein family that this protein belongs to?
Belongs to the FAM227 family.
Protein: PCSK9_SAGLB
Sequence: MGTVSSRRLWWPLPLLLLLLLGPAGTRAQEDDDDDYEELVLALRSEEEGLADALQNGATATFHRCAKDPWRLPGTYVVVLKEETHRSQPERTARRLQAQAARRGYLIKLLHVFHDLLPGFLVKMSRDLLELALRLPHVDYIEEDSSVFAQSIPWNLERITPARYQADEYQPPNGGSLVEVYLLDTSIQSGHREIEGRVMVTDFGSVPKEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASLHSLRVLNCQGKGTVSSTLIGLEFICKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARARVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSRSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGEGWQLFCRTVWSAHSGPTRMATAMARCAPDEELLSCSSFSRSGKRRGERIEAQGGRRVCLAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAGAGMGTRAHCHQQGHILTGCSSHWEVEDLGTHKPPVLRPEGQHNQCMGHRGASTHASCCHAPGLECKVKEHGLPAPQEQVTVTCEEGWTLTGCSALPGTSHVLGAYAVDDTCVVRSRDVSTTGSTSEETVAAIAICCRSQHLAQAS
What is the function of this protein?
Crucial player in the regulation of plasma cholesterol homeostasis.  Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.  Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway.  May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.  Can induce ubiquitination of LDLR leading to its subsequent degradation.  Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner.  Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.  Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation.  Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 9, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity).