PharMolix/UniProtQA huggingface dataset:
Protein: C42S1_HUMAN
Sequence: MSEFWHKLGCCVVEKPQPKKKRRRIDRTMIGEPMNFVHLTHIGSGEMGAGDGLAMTGAVQEQMRSKGNRDRPWSNSRGL
What is the function of this protein?
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.  Alters CDC42-induced cell shape changes.  In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse.  May play a role in early contractile events in phagocytosis in macrophages.
What are the official names of this protein?
CDC42 small effector protein 1, CDC42-binding protein SCIP1, Small effector of CDC42 protein 1.
What is the protein family that this protein belongs to?
Belongs to the CDC42SE/SPEC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Lipid- anchor. Note=Recruited to the activated TCR prior actin polymerization.
Protein: MNMG_CHLMU
Sequence: MWTFPVEYDVIVIGAGHAGCEAAYCAAKMGASVLLLTSNLDTIAKLSCNPAVGGIGKGHIVREIDALGGVMAEVTDLSGIQFRILNQTKGPAVRAPRAQVDKQLYHIHMKQLLEQVPGLHIMQGTAEALLDDGEKVLGVSTKEGWAYSGETVVLSSGTFMRGLIHIGTQNFSGGRLGDAASLGLSKDLKRLGFPLGRLKTGTPARLLSSSIDFSIMEEQPGDQNVCFVHREEAFVPKLPQVSCHITYTTDKTKDLIANNLHRSALYGGRIEGVGPRYCPSIEDKIVKFADKDRHHIFIEPEGLNTREVYVNGLSTSMPFDVQYEIIRSVAGLENAVITRPAYAIEYDYIQGNVILPSLESKILEGLFLCGQINGTTGYEEAAAQGLIAGVNAVNKVLHRPAFIPSRQESYIGVMLDDLTTQVLDEPYRMFTSRAEHRLLLRQDNAGMRLSHYGHALGLLSSERYAMFQKQKNCIEHEKERLAKTFRKYGDSIVPLTKILCRPEVSYQQLLTEFPEDVKDWGPIIGASLEMEIKYSGYISRQQTLIRSMEKAENTLIPEGIDYHSISALSLEAREKLSKFTPRTIGSAARISGISVADIQVLMVSLKKDAY
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_LACCB
Sequence: MKFKTGDKVRVMRGKDAGKEGQITKVLKDADKVVVEGINMIKKHQKPNNANPQGGIIDKEAPIHVSNVMLLDPDTNKPTRIGSEVKDGNKVRIAKKSGTAIDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ISIA_NOSS1
Sequence: MQTYDNPNIKYDWWAGNARFANLSGLFIGAHVAQAALTTLWAGAFTWFEISRYKPEIPMGEQGLILLPHLATLGFGVGVSGQVVNTYPYFVIGALHLISSAVLGAGALFHTFKGPRNLKNTTGSARKFHFEWNDPKQLGLILGHHLLFLGMAALLLVGKAMFWGGLYDATTQVVRVVNHPTLNPFVIYGYQTHFASVNNLEDLVGGHIYVGLILIGGGIWHIVKEPLPWAKKLLIFSGEAILSYSLGGIALAGFVAAYFCAVNTLAYPVEFYGAPLELKFGVTPYFADTVKLADGGYSARAWLANAHFFLAFFFLQGHLWHALRAIGVDFRQIEKSLNAISSAE
What is the function of this protein?
Functions as an antenna for photosystem I (PSI) under iron-limiting conditions, when phycobilisomes disappear.  In the (PSI)3(Isi3)18 complex most of the harvested energy is probably used by PSI; in other PSI-containing supercomplexes a large part of the energy will probably not be used for light harvesting, but rather is dissipated to protect the organism from light damage.
What are the official names of this protein?
Iron stress-induced chlorophyll-binding protein, CP43'.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. IsiA/Pcb subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: SFSA_PSEA6
Sequence: MQFYNSLIEGILVKRYKRFLTDVTLLNGEEVVAHCPNTGAMIGCAEPGMQVWLSPSNNPKRKLGYTWELGVTHQGHWIGINTNNANKIVAEALATHAIQELQGYETVRPEVRFGHENSRIDFLLSSSDKKDCYVEVKSVTLLEEGQGYFPDAKTVRGQKHLRELAAMVEQGYRAVLLFCVQHSGIQSVKIAEHIDPKYAQMFKHAVDVGVEVLAYSCAINEQNITLNQRLPMIV
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: DAPB_ENT38
Sequence: MHDAQVRVAIAGAGGRMGRQLIQAALQMEGVVLGAALEREGSTLLGTDAGELAGAGHSGVTVQSSLDAVKADFDVFIDFTRPEGTLEHLAFCRQHGKGMIIGTTGFDDAGKQAIKDAAQDIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAYALDKDLKDCAVYTREGHTGERVPGTIGFATVRAGDIVGEHTAIFADIGERVEITHKASSRMTFANGAVRSALWLKSKGNGLFDMRDVLNLNEL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_CLOTE
Sequence: MEIYKKIYNSLLKLKEKNPLIHHITNYVTVNDCANIVLAIGASPVMADDIREVEDMVSIASALVINIGTLNKKTVKSMFLAGKKANELNIPVILDPVGVGATKYRTSIALELLEEIKFSVVRGNISEVKVLSGMNASTKGVDAESWDETNPIEERIRLVKSLSEKYNAVIGITGEKDVIGFKEEVYTVENGSSIMAKITGAGCMCTSVIASYCGAEENYLQATLSGVVSMGIAGEIAYEKTKNLGPSSFRTALIDSIYNLEESSFNERGKVYNA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: PAND_HYDS0
Sequence: MKRHILRAKIHRATVTGANLNYEGSISIDERLLEAGKFVVFEKVDIYNVNNGNRFSTYVIPGKPGEISLNGAAARLCMPGDIIIIASYAEVEEEELHHFRPYLVYVDDKNNILEVKRDMEHVFTF
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_RUTMC
Sequence: MKNIRNFSIIAHIDHGKSTIADRFIQFCGGLSDREMSAQVLDSMDIEKERGITIKSQSVTLDYQARNNETYQLNFIDTPGHVDFSYEVSRSLSACEGALLIVDASQGVEAQTIANCYTALDQGLEVVPVLNKIDLPAADPDRVVDEIEDVIGVEAHDAVYASAKSGMGIEDILEQIVEKIPAPKGNIDSPIKALIIDSWFDNYLGVVSLIRVIDGEIRTKTKIKIFSNGKEHLVDEVGVFRPKRKKTNSLKAGEVGFLIASIKNIDGAPVGDTITGAKNSASKPLEGFKPVQPRVFSGIFPISGEDYEKFRDALAKLRLNDAALQYEPENSDALGFGFRIGFLGLLHMEIVQERLEREYNLNLITTAPTVIYEILDTKGVIYRIDSPSKIPINQSIAEFREPIITANILVTDEYVGVIISLCVEKRGVQKNITYMGGQVSLVYELPLNEVVFDFFDRLKSISRGFASMDYRFERYQKSDLIRLDIMINQEPVDVLALIIHRNDSVHKGRELVEKMKKLIPRQMFDVTIQACIGSKIISRSNVKALRKNVTAKCYGGDISRKRKLLDKQKKGKKRMRSVGKVNIPQEVFLAVLHID
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MURC_PECAS
Sequence: MNTQQLAKLRSIVPEMHRVRHIHFVGIGGAGMGGIAEVLANEGYEISGSDLAPNAVTQQLTKLGAQIYFHHRAENVLNASVVVVSSAITADNPEIVAAHDARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVTSIYAEAGLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGQAVMCIDDAVIRELLPRVGRHITTYGFSDDADVRVAGYRQTGAQGHFTLERKDKTLLNVTLNAPGRHNALNAAAAVAVATDEGIDDEAILRALERFQGTSRRFDFLGEYPLELVNGQSGTAMLVDDYGHHPTEVDATIKAARAGWPDKRLVMIFQPHRYTRTRDLYDDFAHVLSQVDVLLMLDVYSAGESPIPGADSRSLCRTIRGRGKIDPILVTDMDTLPELLSQALRGEDLILVQGAGNIGKLARKLADSRLQPQISE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_NAUPA
Sequence: MIQPFTRLKVADNSGAKEIMCIKVLGGSKRRYASVGDIIVASVKKALPNGKIKKGQVVKAVIVRTKKEVQRENGSLIRFDDNAAVIIDAKKEPIGTRIFGPIAREVRYEGFQKITSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RDRP_I77AB
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSERGRWTKNTETGAPQLNPIDGPLPKDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLMANESGRLIDFLKDVMESMDREEVEITTHFQRKRRVRDNVTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHAGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWVPKRNRSILNTSQRGILEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKTCSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: GLGA_DEIRA
Sequence: MRVLHLASEVFPFSRSGGLGDVLGALPAVQARLGEDAEVTVLSPWYASLQGEPQELWRGEAWGEQAWLGELRQDGVRYLFLGLNEFQRPGLYHPDDVERFCAFGRAALPALDAVGVTPDVLHGHDWQAGLVVAHARLRGLRTAFSVHNLQYQGRWNLHEAAGWTGLPDWTFGPDGVEFFGDLNLMKAGLNFAGHVTTVSPTYAQEITTPQYGEGLEGLLVRLTHEGRLSGILNGLDQDRWNPRTDPDIAAYSDPAGKAGAVKALRQEFGLDDAPILATVSRLADQKGMDLLITALPELVRDWNVVVLGGGDPLLEAALTGWANHPRVAFASGMNEPLAHRIYAGAHAFAMPSRFEPCGLSQLIAMRYGTLPIVRETGGLADTVPPEVGFRFADATAPAFLQACREAQAAFQDPAQWQTRATRAMSLDFSWDGPARQYLELYRGL
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: MSHR_PUMYA
Sequence: MSVQGPQRRLLGSVNSTSPAAPRLGLAANQTGPRCLEVSVPDGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSSVLETAVMLLLEAGTLAGRAAVVQQLDDIIDVLVCGAMVSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYDHTAVLLCLVSFFVAMLVLMAVLYVHMLARACQHARGIARLHKRQRPVHQGLGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPRHPICGCVFKNFNLFLTLIICNSIVDPLIYAFRSQELRKTLREVLLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH (By similarity).  The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity).  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IX10L_ARATH
Sequence: MKLSSCVLIFLLCNTFSSISAFRLSRSQPTERISGSAGDVLEDDPVGRLKVFVYELPSKYNKKILQKDPRCLNHMFAAEIYMQRFLLSSPVRTLNPEEADWFYVPVYTTCDLTPNGLPLPFKSPRMMRSAIQLIASNWPYWNRTEGADHFFVVPHDFGACFHYQEEKAIGRGILPLLQRATLVQTFGQRNHVCLKEGSITVPPYAPPQKMQSHLIPEKTPRSIFVYFRGLFYDVGNDPEGGYYARGARAAVWENFKDNPLFDISTEHPTTYYEDMQRAIFCLCPLGWAPWSPRLVEAVIFGCIPVIIADDIVLPFADAIPWEDIGVFVDEKDVPYLDTILTSIPPEVILRKQRLLANPSMKQAMLFPQPAQPGDAFHQVLNGLARKLPHERSVYLRPGEKLLNWTAGPVADLKPW
What is the function of this protein?
Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls.  Probably involved in the elongation of glucuronoxylan xylosyl backbone.
What are the official names of this protein?
Probable beta-1,4-xylosyltransferase IRX10L, Glucuronoxylan glucuronosyltransferase 1, AtGUT1, Glucuronoxylan glucuronosyltransferase 2, AtGUT2, Protein IRREGULAR XYLEM 10-like, Xylan xylosyltransferase IRX10L.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 47 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: PVK2_SPHVI
Sequence: GGSSGLIAFPRL
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, Sphvi-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS10_THEMA
Sequence: MPGQKIRIKLKAYDHELLDESAKKIVEVAKSTNSKVSGPIPLPTERTLYCVLRSPMKHKDSREHFEKRVHKRLIDIIDPSPKTIDALMRINLPAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: IF11_RALSO
Sequence: MAKDDVIQMQGEVQENLPNATFRVKLENGHVVLGHISGKMRMHYIRILPGDKVTVELTPYDLSRARIVFRAK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFI44_HUMAN
Sequence: MAVTTRLTWLHEKILQNHFGGKRLSLLYKGSVHGFRNGVLLDRCCNQGPTLTVIYSEDHIIGAYAEESYQEGKYASIILFALQDTKISEWKLGLCTPETLFCCDVTKYNSPTNFQIDGRNRKVIMDLKTMENLGLAQNCTISIQDYEVFRCEDSLDERKIKGVIELRKSLLSALRTYEPYGSLVQQIRILLLGPIGAGKSSFFNSVRSVFQGHVTHQALVGTNTTGISEKYRTYSIRDGKDGKYLPFILCDSLGLSEKEGGLCRDDIFYILNGNIRDRYQFNPMESIKLNHHDYIDSPSLKDRIHCVAFVFDASSIQYFSSQMIVKIKRIRRELVNAGVVHVALLTHVDSMDLITKGDLIEIERCEPVRSKLEEVQRKLGFALSDISVVSNYSSEWELDPVKDVLILSALRRMLWAADDFLEDLPFEQIGNLREEIINCAQGKK
What is the function of this protein?
This protein aggregates to form microtubular structures.
What are the official names of this protein?
Interferon-induced protein 44, p44, Microtubule-associated protein 44.
What is the protein family that this protein belongs to?
Belongs to the IFI44 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RXLRH_PHYIT
Sequence: MRFSAFLTLLLVAFVASCSTFASAESVAEGRRLRADAAPVPVNKDNVAKLAGGFLEKLKTNTALTKAANTIKNSNADEAAVRKAITTFAAAKESAKMSDEGIAKISAMMAGTVQKNPKSWPRLRKFAKVTLGATVAGFAIYGAYKALFDRKSSTAATTTTTTGSA
What is the function of this protein?
Effector that enhances P. infestans colonization of Nicotiana benthamiana leaves.
What are the official names of this protein?
RxLR effector protein PITG_09218.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host mitochondrion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: CBIM_SEBTE
Sequence: MKNKSRIYLIASAFLILSVSSYSMHIMEGYLPVKWAVFWFILCAPFWIYGLVKLQKEAKGNVEEKLTLALAGAFIFVLSALKIPSVTGSSSHPTGVGLSAILFGPFITSILGTIALIFQAVLLAHGGLTTLGANAFSMAVAGPLVSYGIYRLLKKKNKSLAVFLAASLGNLSTYVITSFQLALANPSADGGITASFVKFAMIFAVTQIPLAVIEGLLTNVVMNLLEKYNIKQGVKA
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
What are the official names of this protein?
Cobalt transport protein CbiM, Energy-coupling factor transporter probable substrate-capture protein CbiM, ECF transporter S component CbiM.
What is the protein family that this protein belongs to?
Belongs to the CbiM family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYH_ECO5E
Sequence: MAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNSIGSLEARANYRDALVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQALLNDAPALGDYLDEESREHFAGLCKLLESAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAPK2_RABIT
Sequence: PPPPPPQQFPQFHVRSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFSKKTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPKAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
What is the function of this protein?
Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation.  Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates.  Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue.  Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36.  Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (By similarity).  Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively.  Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs.  Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcripts.  Phosphorylates CEP131 in response to cellular stress following ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (By similarity).  Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA.  Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
What are the official names of this protein?
MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAP-K2, MAPKAPK-2, MK-2, MK2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.
Protein: NARK1_THETH
Sequence: MIHDPAQLEKERPDRLRVLWLSTLAFTLMFAAWLMFGVLGVPIRKEFGLSDVQLSWISALAILNGSLWRLLAGILADRYGGRLVFTLMLFFTAIPAYLVSRAGSYEELLLYAFLVGFAGNSFSVGIAWNSAWFPKDQQGFALGVFGAGNVGASVTKFIGPALIASVPASGYLGGLIPGGWRFIPFLYAVLLVLMGFVLWFGTPRKDKRPGQGRPFLDMLKPLRYVRVWRFSLYYVVVFGAYVALSAWLPKYYVDVFGLPLHEAALLTALFIFPASLLRPVGGYLSDRFGARRIMYWTFGIILLASGVLMMPEGHIVLYTKQGAKEVMQFTMGVELFTLLVFLIGVGMGIGKAAVYKHIPTYFPQDVGAVGGLVGMLGALGGFFLPPLFAYAQAWTGLPQMTFFVLFLLAAISFLWMHLTVLKLLQQEAQHLKNDFELKGDRPC
What is the function of this protein?
Probable nitrate/nitrite antiporter that may be involved in nitrate import and nitrite export during anaerobic growth.
What are the official names of this protein?
Probable nitrate/nitrite antiporter NarK1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.