PharMolix/UniProtQA huggingface dataset:
Protein: ZN668_HUMAN
Sequence: MEVEAAEARSPAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATHGPADCSEEVAEVKPKPETEAKAEEASGEKVSGSAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYACADCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQRAHEGVKPYHCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEAAGVPPAQELVVGLALPVGVAGESSAAPAAGAGLGDPPAGLLGLPPESGGVMATQWQVVGMTVEHVECQDAGVREAPGPLEGAGEAGGEEADEKPPQFVCRECKETFSTMTLLRRHERSHPELRPFPCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPMGTPTPLEPLVALLGMPEEGPA
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 668.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCH11_PSEAE
Sequence: MNPALSQHYREILVGLGEDPQREGLLDTPKRAAKAMQYLCHGYGQTLEEIVNGALFASDNDEMVIVRDIELYSLCEHHLLPFIGKAHVAYIPTGKVLGLSKVARIVDMFARRLQIQENLTRQIAEAVRQVTSAAGVAVVIEAQHMCMMMRGVEKQNSQMFTSVMLGAFRDSNTTRQEFLQLIGRSK
What are the official names of this protein?
GTP cyclohydrolase 1 1, GTP cyclohydrolase I 1, GTP-CH-I 1.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: CCPG1_MOUSE
Sequence: MSESSSDSDSSCGWTVINHEGSDIEIVNSATASDNCGLTLECSLVEQEELPVLYVGHGGEESSANNTSSVGETMLSSMRETKSAAEVEEAPSPEDNVYFGTTSDDSDIVTLEPPKLEEMGNQEVTIQEAPSSDDLNMGSSSSSQYAFCQPEPVFSSQPSDEESSSDDTSHEPSPAPRRRRNRKKTVSISESEEPPLAEPEDEPSKEPSKRHFSRGLNKCVILALVIAVSMGFGHFYGTIQIQKQLVRKTHEDELDGVKGYLSQRKQEQESFLDFKSLKENLERCWTVTESEKITFETQKKNLAAENQYLRISLEKEEQALSSLQEELRQLREQIRLLEDKGTSTQLVRENQVLKQYLEVEKQKTDSFLREREMLLEEARMLKRDLEREQLTAMALRAELEQFIPGQAQSRAESPSVQTEEKEVGLLQQRLAELEQKLIFEQQRSDLWERLYVEAKDQHGKQETDGRKRGSRGSHRAKSKSKETFLGTVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGSKRFRAPKEAATEKTRTAYSYSSYSQQEAPNQNQNCRRPSAQRDGGREKPSHSEEIRKNANSYTYKAKSDCRGTHSTRRVCSGMFECAGQEAISPVNKASPVRMNDFKQLIHWYLLNELETFHHWKELDQFISPFFPNGVFRHDQQLFADFVDDVKGYLKSIKEYRVEDGNLEKLDGCIYRHFGHVFALPFGPRSVYIKPCYYNSF
What is the function of this protein?
Acts as an assembly platform for Rho protein signaling complexes.  Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity.  Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42.  May be involved in cell cycle regulation.
What are the official names of this protein?
Cell cycle progression protein 1.
What is the protein family that this protein belongs to?
Belongs to the CCPG1 family.
What are the subcellular locations of this protein?
Cytoplasmic granule membrane; Single-pass type II membrane protein.
Protein: YL108_YEAST
Sequence: MSGQKGEIVVYTKELETTPELLPNHEVFKIRIGQKLFEISGATLNSDAPNFFTQFFNTHDKNTILFVDRSEDVFIIIYRHLQGYFPDIKNEVQFTCLFADALYFQLPKLVKLIKEYDYHFTNIGGVPFKVPKSLFHEEGNRLNYFETISRISYEEIEKWESNKKPGFPPLLPPSYIARSPEFFRDILSLLGGSKLELSEERTASLIKECRYYRLNRLEQELVRAKIIYNPLTNCQEVCIALDSVSKKGVTIERLTSLHTGNQSLAVSSCLNGTEGEKAATGFHKTETDSGNNDEYEPPTKKVKHCIERHWSMLKYQRPYIDTVSHDLIFQLHSNQCKIIFNKKNKTVHVDLSREAAVLFENKFSDVLLENPDFKIDLSEYKVKLRDSQMQVESHLIIPACVSICDLTVNGAKCCNIFSLVNDSKCKGRVLDCTNLKVLNCVHGLKLHLSKSMWKLGTNNGRIILVAVKAETFSGTKEYCKMIDFL
What are the official names of this protein?
BTB/POZ domain-containing protein YLR108C.
What are the subcellular locations of this protein?
Nucleus.
Protein: SMKTR_MOUSE
Sequence: MEKFHAQYEMLETIGQGGCAQVKLARHRLTGTHVAVKVIVKRECWFNPVMSEAELLMMTDHPNIISLLQVIETKKKVYLIMELCEGKSLYQHIQNAGYLQEDEARPLFKQLLSAMNYCHNQGIVHRDLTPDNIMVEKDGKVKIIDFGLGTQEKPGQNHNLFCEIYPFSTPEVLFNRPYDMRKIDVWGLGVVLYFMVTGKILFDTASVEKLRKQIVAEKCSVPCRLSVELQDLIRLLMTDIPELRPTVAEVMVHPWVTEGSGVLPDPCEEHIPLKPDPAIAKAMGFIGFQAQDIEDSLCQRKFNETMASYCLLKKQILKECDRPIRAQPMNPSVTPLSSLVDAPTFHLGLRRTETEPTGLRLSDNKEVPVCGNSTSKKRERSFSGPGVLSRPINTTPTMDQTHTRTWSGPCIYSNVCTIHPNSINESTEGHISTSAEDKPVHSRGWPRGIKGWTRKIGNAMRKLCCCIPSKETSHLGQRRVCPKI
What is the function of this protein?
While the main function of Smoks is to control sperm motility, the role of Smok-Tcr, with reduced kinase activity, is to counterbalance a signaling impairment caused by the distorter/sterility loci, giving t-sperm an advantage in reaching the oocytes.  Transmission ratio distortion also called segregation distortion is the name given to the phenomenon above-mentioned.  Being associated with the T-complex, it allows males heterozygous for a complete t-haplotype to preferentially transmit the t-haplotype chromosome.
What are the official names of this protein?
Sperm motility kinase Tcr mutant form, SmokTcr, Tcr, Dominant negative form of Smok, Responder protein Smok-Tcr.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Smok subfamily.
Protein: DDH_HAEIN
Sequence: MKIAIYSTKSYDRKYIELINAKYNFDLEFFDFMLNESTVRLAEHCEVVCIFVNDNGSRKVLEKLAALGVKIVALRCAGFNNVDLKAAQELGIQVVRVPAYSPEAVAEHTIGLMMTLNRRIHRAYQRTREANFSLEGLIGFNMYGRTVGVIGTGKIGIAVMRILKGFGMNILAYDPFKNPVVEELGGQYVELDELYAKSHVITLHCPATPENYHLLNCEAFAKMKDGVMIVNTSRGSLIDTQAAIDALKQRKIGALGMDVYENERDLFFEDKSNEVIQDDIFRRLSSCHNVLLTGHQAFLTEEALTNIADVTLSNIYKLKSGKVCENIVLPS
What are the official names of this protein?
2-hydroxyacid dehydrogenase homolog.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: MSRB_VARPS
Sequence: MTTPIEKTDAEWKALLAEKGAEPAAFEVTRHAATERPFTGKYEAHWDDGTYHCICCGAKLFESSTKFDAGCGWPSFSQEAVPGAIRNIVDRSHGMVRTENVCANCGAHLGHVFPDGPTETGLRYCMNSASLDFKKK
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: PYRG_RHORT
Sequence: MTRFIFITGGVVSSLGKGLASAALGALLQARGYKVRLRKLDPYLNVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGVSARRSDNVTTGRIYSDVIARERRGDYLGKTVQVIPHVTDAIKEFATADLTDEDFVLCEIGGTVGDIESLPFLEAIRQLRNEMGAERSLIIHLTLLPYIPSAGELKTKPTQHSVKELLGLGIQPDLLMCRSDRPIPEAERNKISLFCNVRREAVIPALDVDTIYQVPVSYHAQGLDVQVCRHFHLPMNEDLDLTRWQTIVDRVRHPEGEVTIAVVGKYTSLIDSYKSLAEALVHGGIANAVKVKLVWLDSEIFEREDAVHYLEGVNGILVPGGFGERGSEGKIEAARFARERSVPYFGICFGMQMAVIEFARHVAGLPGASSSEFGVPEVPLVGLMTEWVRGNERVARGSGDDLGGTMRLGAYECHLRALSKVREIYGAEVIHERHRHRYEVNVTFKDQLEEKGLAFSGMSPDGVLPEIVELPDHPWFIGVQFHPELKSKPFDPHPLFTSFVQAAITQSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ATPD_LEIXX
Sequence: MGSATREARARSVSALAGLGSKADLATAEDLFAAGRVVADSVQLRAVLSDPAADRSGKDVLVKRVFGALSAPAVELLGVIAGERWSGQDDVLDAIEELGIRSIAASAPRTVDIPAELLAFGGAVTSDAELELALRSKLADPSAKAALVERLLVGKAAGQTVAITRQLVLQPRGRSVRQALREAARIVAAQDGQTIATVVTATPLPAAQAERLRASLAAKYGDLKLNQVVDPSILGGMRVQIGGDVIDGSVSSRLSKLRLQLAG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RPOD_COXBU
Sequence: MPSRKKKSSVTKTKKKTTGKKARVTAKAKPSVKSKLKTVKRAPAKPKSVTVAKTKSKKEKAKVVSQPLPKTAEKKPSAPPSETQQPKIGENAAESQRLGFGALLEEAKNKGYLVHEDLINLLPNDYADPSQMEGIIGRLTEMGIKVFEIPPDADSLLLEEDTQSDDDEINEDVAEVLATETRTTDPVRMYMREMGSVELLTREGEIVIAKRIEEGIRQVMGAVVQYPELIEKFIKEYDTIVATEGRLSDLLIGFFDEEESTASPVAPEARDKEAETSDEDDGGEGGSDEFGESGPDPLITQQHMEELKKLYGRYQNAIKRYGKKAPATLKHQKALAELFSTFKLSIKQFNRLTGQLRRMLRAARAQERLIMSYCVVKAKTPRKKFIASFPHNETNMKWLEQYKNENKEQAKRLEKYSKEIYRAQRNLAQLEEQNNLNIQEIKEINRRVAIGEAKSRRAKKEMIEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQILQETGIEATPEELGRRMDMPEEKVRKVLKIAKEPISMETPIGEDEDSNLGDFIEDINMESPVDFATSAGLMEATREILSTLTPREAKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRAEKLHSFIEVEE
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor RpoD, Sigma-70.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_THEVB
Sequence: MHNPQSRGHNLSQAMSDQTVTNPAAEAQEGEITPDTPDTVDKVENTPVENVENPAEATPGEEDQASEATSANAADLLEQIAALEAAKASLSQVVEERNSQYIRLAADFENFRKRTQREKEELELQIKCSVIADLLPVVDSFELARTHIQTETEAEEKIHRSYQGVYKQLVECLKRIGVSAMQAKGKPFDPNLHEAVLREATNEHPEGTVIEELKRGYMLGDRVLRHAMVKVAAPPEEGSASNTNPTNDVTDV
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBP71_SCHPO
Sequence: MVLSNVDAEEVNMDSSMELEESSQEPLRADNYEEIYNSLVHHEPDLEEAAHASYSWVVKNFSTLEDKTYSPLFKAGHTTWRIVLFPKGCNQTEYASVFLEYLPQCKVEAIRKYEAELAAGKTPTIDPEIVNDETYSCCAQFALSLSNVQDPTVMQINTSHHRFRSEVKDWGFTRFVDLRKIAVPTPEFPVPFLENDEICISVTVRVLQDPTGVLWHSFVNYNSKKETGYVGLKNQGATCYMNSLLQSLFFTNIFRKTVYKIPTDNDDSRDSVAYALQRVFYNLEKQREPVSTTELTRSFGWNSFDSFMQHDIQEFNRVLQDNLEKKMKGTEVENALNDIFVGKMKSYVKCIDVNYESSRVEDFWDIQLNVKGMDTLEDSFRDAIQVETLTGDNKYYAEGHGLQDAHKGIIFESLPNVLQLQLKRFDYDMLRDMMVKINDRHEFPLEIDLEPYLSETADKSESHVYVLHGVLVHGGDLHGGHYYALIKPEKDSNWFKFDDDRVTRATIKEVLEDNYGGEPAGRAKGYNGNPFKRFMNAYMLVYFRKSRLDHILSPVTAEDVPFHVRNTLDEEHRVVERKLLEREEQQIYRRVRVLTTDGFKKYHGFDMTDFSASDDDPVLITTKIKRNANIWDLQKHLAGLLNRDTSGIRIWLMTNRQNRTVRVDLPLDKKTILVDQICDMHIRKDMDMRVYVEFLSEHNQLLADFGATDDNDFDTYIFLKIFDYETQQISGLADLHVSKNSPISSLSEWIREHLKWSSDVPITYYEEIKTGMVDVLDPNASFEKSEIQVGDIICFEKKLVHDSSSDTSHPYKSALDLYDFMAHRVVITFEPRYSDDTNNGVFDLVLTTHTNYTDMARAVANKLNVDPNYLQFTMAHLPSRTPRSVIRNPSKFTLQNAIPSTYSHNQNVVMFYEVLDITLSELERKQLIRVHFLSNGISHETQMEFYVDKEGTVEDILRQVTQKVPLNAEDASRLRLYEVYNHRILKSHLPTDGIYDLNEFSTAYVEVTPKEEQMQLKTDDAVSIVVQHFFKDLSRLHDIPFYFVLLRGETLKDLKKRLQKRLGYNDTQFSKVKLAVLQAQSFGKPYYLTDDDEVLYGELEPQSHILGLDHPPANGSAQYHGMDQAIRMK
What is the function of this protein?
Hydrolase that deubiquitinates target proteins (By similarity).  Cleaves the UBL propeptide in sde2 (PubMed:28947618).  Involved in regulating the steady-state levels of proteins including prp4 (PubMed:11919719).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 15, Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: SODC_SHEEP
Sequence: MATKAVCVLKGDGPVQGTIRFEAKGDKVVVTGSITGLTEGDHGFHVHQFGDNTQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVKADKNGVAIVDIVDPLISLSGEYSIIGRTMVVHEKPDDLGRGGNEESTKTGNAGGRLACGVIGIAP
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YTM1_LODEL
Sequence: MSDDKNQIKIKFTTNESDESLKVEETPLYVPVTLKRYGLSEIVNHLLETQKALESESGEDDEERKPVPFNFLINGELLRTSISDYLTRNGLSSEAFLTIEYTRAILPPSFQASFQNDDWISSLDSINRNLSAVTSSQLTITNPKILSGSYDGIVKTYNMSGKVEKQYMGHSAAVKSVKWISPTRIVSCGNDQQVRLWKTAYEGVVDQNEEDEEENEANEGDDGDNDMEKIEDGKTLAILEGHKAPVVDLAVNQQTKRILSAGYDLNVGFWSTNYKDMAKISIPEYDSNVISTSSKKRRKLALQDATIRRRSPLSLLLGHTEPVEGVIFDELDATVGYSVSQDHTIKTWDLVTLRCVDTRTTGFSLLSILQLPQVNLIATGSSARHINLHDPRVSASNTNSEVVNTKLVGHTNFVVGLSASPHNSNMFASSSHDGTVKVWDIRADKSLYTITREDGSTKSKIFGVCWDSEIGLISGGEDKRVQINKGSDISK
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein YTM1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR12/YTM1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: DEOD_HAEDU
Sequence: MTPHINAPAGAFADVVLMPGDPLRAKYIAETFLENAEQVTNVRNMFGYTGTYKGRRISIMGHGMGIPSCSIYAKELITEYGVKKIIRVGSCGAVRADVKLRDIVIGSGACTDSKVNRIRFRDNDFAAIADFEMTLAAYQVAKQKNISVQVGNLFSADLFYTPDVAMFDVMEKYGILGVEMEAAGIYVVAAEYGVKSLAICTVSDHIRSGEKLSAEDRQLTFNEMIEIALESVLIGDQT
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: TIPIN_DANRE
Sequence: MIDPLENGLFDIPDYEQIEDETFPPLPPPLSPGRAELEDDLFGNAEGEEEGEVSKLAEVPVAKRRTVKRPRPKLDANRLISEKGLPALRTLFEDVKFKGKGHETENLKLLMLKMENWAHRLYPKMQFEEFIDKVENLGGKKEVQTCLKRIRLDMPITHEDYVAEEAEIQVPEESVPSGDGGFPEDPFIHSTPAPASLTEEQQQRIELNKRLALERRLAKQKQLESTPISIQEDADEPSTSSSGQFLSEENPKTTSNQTPLKHKPAELQESPLHDNESSSHIANGIIDDDDDDDD
What is the function of this protein?
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.  Important for cell survival after DNA damage or replication stress.  May be required for the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).
What are the official names of this protein?
TIMELESS-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the CSM3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VSPB_CROAD
Sequence: MVLIRVLANLLILQLSYAQKSSELVVGGDECNINEHRSLVLVYSDGIQCGGTLINQEWMLTAAHCDGKKMKLQFGLHSKKVPNKDKQTRVPKEKFFCLSSKNNKEWDKDIMLIRLNRPVNNSKHIAPLSLPSKPPSQDTVCNIMGWGTISPTEETYPDVPHCANINILDHAVCRAIYPGLLEKSRVLCAGILEGGKDTCGGDSGGPLICNGEIQGLLSVGGDPCAQPHVPALYIKVFDYTEWIQSIITGNTAATCPP
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Snake venom serine proteinase 11, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AROB_STRT1
Sequence: MKLEVNLKQNPYDIIIEKGALKGVGQWVKSLWEPQKIALITDNHVRGLYAEKVKLSLENEGFEVVVFDFLEGEASKNLKTVNKAYEFLIKNGMTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQVPTSLTAQVDSSIGGKTGVNTPFAKNIVGTFAQPDGVLIDPNVLKTLGKRELIEGMGEVVKYGLIDDPELWQLLDNIDGSVHSILENSETIIYRSCNVKRKIVVEDEFEGGVRMYLNFGHTIGHAVEQTAGYGKVMHGEAVAIGMVQISRVAEKKKLMPQGITRQIAEMCVKFGLPVDYEPWRVEELYTALTHDKKARGNSIKTVIVPEIGKAAINQIPLIEMKEYLEK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPSS_METVS
Sequence: MDINIDKYKNITRNLERDIVNLNPIQRGGILPTEAKKVIYEYWDGYSVCDYCSGRLDKIETPPINEFLDDMSKFLGMDITRPTHGARESKYAVMNAICKKGDYVVLDGNSHYTSYVALERANLNYVKTDVEEYPNFRVIPKSYAEKIDELEDSGKNIGLILLTHVDGSYGNVSDVSKVGKIAKSKGYPLLLNCAYSVGRMPVDGKKLNVDFIAASGHKSMAASGPCGLLSINAEYEDEILKTSKVNVVKELQMLGCTSRGIPILSLMASFPHIIERVKNWNLELEKTRKVVFEFEKLGFIALGEKPRNHDIIRFETPVLDKIAEKDKRRGFFFYEELKKRGIGGIRRGVTKEFKMSVYGLTGMQVDYIIDCIKSIVLENAN
What is the function of this protein?
Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
What are the official names of this protein?
O-phospho-L-seryl-tRNA:Cys-tRNA synthase, Sep-tRNA:Cys-tRNA synthase, SepCysS.
What is the protein family that this protein belongs to?
Belongs to the SepCysS family.
Protein: MUCEN_MOUSE
Sequence: MRLLQATVLFFLLSNSLCHSEDGKDVQNDSIPTPAETSTTKASVTIPGIVSVTNPNKPADGTPPEGTTKSDVSQTSLVTTINSLTTPKHEVGTTTEGPLRNESSTMKITVPNTPTSNANSTLPGSQNKTENQSSIRTTEISVTTQLLDALPKITATSSASLTTAHTMSLLQDTEDRKIATTPSTTPSYSSIILPVVIALVVITLLVFTLVGLYRICWKRDPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN
What is the function of this protein?
Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
What are the official names of this protein?
Endomucin, Endomucin-1/2, Mucin-14, MUC-14.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TIG_CHLAB
Sequence: MSRNFSNEQFSVNLEEQPGCVVSAEVKTTPQLLDKLHKQAIKKIKKDVILPGFRKGKAPDGIIVSRYPSQVTKELNQLLIQSAYQALASVGDRRPLSPQAIKSTSVTKADINEGGQVNFTYEAFPTISDIPWDKLSLSEEPAVKDITDEEMEKGLQNISYFFATKTPVTRTSQEGDFISLSLHVSKQNEEGVPTPIFENKYFKLCEEEMTDAFKTKFLGISAGHRVTEIIASPEIQSFLNGDVLTFTVNAVIEVVAPELDDDKARQLQAESLEDLKKKLRIQLENQAKDRQHQQCFAEAENALASIIDFDLPTSMLEDRLAMLTRAKLLNARLIQYCSDEELENKKSDLLKEAELEAKKTLKLFFLANKIFNDEKLVISREELQYMMDVCSRERYGMQPPRDISKEALQELVMAARDRLTYHKAMEKVLAKAKESATAPSA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: COQ4_KLULA
Sequence: MFTVSKKSLQASRNAFSPLNNSKRTIVFTAIAAFGDLLIGKDVRLADAMEKGNLHNKNGEYEHKMEQRTQERLNALRNTRPIEPNYEGHVPLWWYERMMLFGISGLKSYFHPENGENIVQLGEATALPCFLESLKRTMLLDKTGRRILQDRPNITSESLDMERLSKMDKNSVGYTYYKWLMKEGVSPDTRAPVTYIDDPVHAFIFKRYRQCHDFYHAINDLPIIIEGEIAVKAFEASNIGVPMAALGALLAPLRLKKVQKERLYSIYLPWAVKAGLNCKPLINVYWEEILDKDIDELRRELNVTPPPDLRKIRKERAKQRKQFKLKYETYEK
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4, mitochondrial, Coenzyme Q biosynthesis protein 4.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: EFTS_MYCMM
Sequence: MANFTAADVKRLRELTGAGMLACKNALAESDGDFDKAVEALRIKGAKDVGKRAERATAEGLVAAKDGALIELNCETDFVAKNAEFQKLADDIVAAAVASKAADVDALKAASIGGQTVEEAIGALSAKIGEKLELRRVAIFGGTVETYLHRRAADLPPAVGVLVEYTGAGAEAAHAVALQIAALKARYLSREDVPEDLVASERRIAEETAKEEGKPEQALPKIVEGRLNGFFKDAVLLEQPSVSDSKKSVKALLDDAGVTVTQFVRFEVGQA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP18B_ARATH
Sequence: MSARPEGSPPEVTLETSMGPFTVEMYYKHSPRTCRNFLELSRRGYYDNVLFHRIVKDFIVQGGDPTGTGRGGESIYGSKFEDEINKELKHTGAGILSMANAGPNTNGSQFFITLAPQPSLDGKHTIFGRVCRGMEVIKRLGSVQTDNTDRPIHEVKILRTKVID
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase CYP18-2, PPIase CYP18-2, Cyclophilin of 18 kDa 2, Cyclophilin-18-2.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP6_ROTWI
Sequence: MEVLYSLSKTLKDARDKIIEGTLYSNVSDLIQQFNQMIVTMNGNDFQTGGIGNLPIRNWTFDFGLLGTTLLNLDANYVETARTTIEYFIDFIDNVCMDEMARESQRNGVAPQSEALRKLAGIKFKRINFNNSSEYIENWNLQNRRQRTGFVFHKPNIFPYSASFTLNRSQPMHDNLMGTMWLNAGSEIQVAGFDYSCALNAPANIQQFEHIVQLRRALTTATITLLPDAERFSFPRVINSADGATTWFFNPIILRPNNVEVEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVNALFPQAQPFQYHATVGLTLRIESAVCESVLADANETLLANVTAVRQEYAIPVGPVFPPGMNWTELITNYSPSREDNLQRVFTVASIRSMLIK
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RLMH_LIMF3
Sequence: MNIKIIGVGKVKEKYFKAGIAEYAKRMERYAKFEIVEVPDEKAPETLSQAEMDAVMAKEGERILAKIKDREYVYALAIKGKERSSEEFAKEINQLATYGHSDITFVIGGSLGLSPAVLKRANTQISFGRFTLPHKLMRLVLAEQIYRAFTIINGLPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.