PharMolix/UniProtQA huggingface dataset:
Protein: TIG_UREPA
Sequence: MKLLNKIKNENAIEFQILIEKSEWEKKHKESFEKIAKKTASKLKIPGFRPGKVPVEEAKKHVNEIEVFETTTNDLIPQVLTFLEQDESFINDDSETVDTPSVDILDFKDGELSLKVVYDLYPVATIESYNDLILTPIVNEAFEHEVNAEIEHALNSKSQRRVKDDNEFIEKGDEVRFDFKGMIDSVPFEGGSAKDHLLTIGSNQFIPGFEDQMIGLKKDERKNINVKFPDDYHATDLAGKAAVFEVFIKEITNVKPQELNDEFAKSFNLPNVNTVQELKDYIHNQIVLAKQEKNSERAWLEIAQQLLAKAKITPIPQSLIDREVSTLRQQVLSQLSQYKIELKQYLEFSKKSEAQFQEDLIRQAKETITLALLVDDIAETQNIVVSDEEVKERVAEMAKLYQGEEQAVIEQLSKNPDAVKEFLLHKKVVNYLIDLNKNNQPKNTTLSSK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: Y866_HAEIN
Sequence: MDKIALKITFSAETPKYAQSVLTEYVNFVSQYSLNQTNQEFKQGFNLRLDELRFSKEQIEENLTEEKKVQVENLTNALDIAKKAGIKDFSRGNNISDSKLADGTYLFILAEKYLQAQLDIAKNTPVVYPANYYITDRQLFKLNKLASQLELVEDVKTYYYLSSPDYPVVKDNPKRSLILAIGFIIGILLPTFFILLGSVIQTNKKQS
What are the official names of this protein?
Uncharacterized protein HI_0866.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PRP1_LOTGI
Sequence: MMKLGLYLTLLFLSVWTVSGEPFKCTNICGKGAIIIAGVAYCCPQGYKPMIRRKMEDAFMATDCDCLFMMPAGQGMYAQYPQAPNQGSFIVQQPPQAPAVAVAPAAATVQVVAPAPTVVAAPPAAPPPPPPVVKVAPPAPRLPTYKPMYQMIRQQPMRQQRTWYHRPAPTYAAPTKSTKPKHEFFKFLDDFLSKQGYRGGNRG
What are the official names of this protein?
Proline-rich protein 1, Uncharacterized shell protein 6, LUSP-6.
Protein: PTFB2_ECOLI
Sequence: MTKIIAVTACPSGVAHTYMAAEALESAAKAKGWEVKVETQGSIGLENELTAEDVASADMVILTKDIGIKFEERFAGKTIVRVNISDAVKRADAIMSKIEAHLAQTA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II FrwABC PTS system is involved in fructose transport.
What are the official names of this protein?
PTS system fructose-like EIIB component 2, Fructose-like phosphotransferase enzyme IIB component 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA_I79A1
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIMEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSSIENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCKDVSDLKQYDSDEPDTRSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQVIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALK
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: RECA_PSEF5
Sequence: MDDNKKKALAAALGQIERQFGKGAVMRMGDHDRQAIPAISTGSLGLDIALGIGGLPKGRIVEIYGPESSGKTTLTLSVIAQAQKAGATCAFVDAEHALDPEYAGKLGVNVDDLLVSQPDTGEQALEITDMLVRSNAVDVIIVDSVAALVPKAEIEGEMGDMHVGLQARLMSQALRKITGNIKNANCLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRTGAVKEGDEVVGSETRVKIVKNKVAPPFRQAEFQILYGKGIYLNGEIIDLGVLHGFLEKSGAWYSYQGNKIGQGKANSAKFLQDNPEIGNALEKQIREKLLTASPDVKANPVKETEDDMADADI
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y773_ACTP7
Sequence: MAKKRSKNEIDWTDEEEEIIWVSKSEIKRDSEHLKKLGAELIELTPQNLEKIPLDDDLKDAIRQAQSFKLEARRRQIQFIGKLLRNRDPEPIQEALDKVKNRHNQQQALLHKLELVRDQLVNMGDSSLEHLLTEHPQLDRQHLRNLIRGAQKEREANKPPKNYREIFQYLKTEIAE
What are the official names of this protein?
UPF0307 protein APP7_0773.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: NUDT4_RAT
Sequence: MKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGVEPEEEPGGAAAREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLERLKLGCSPTNGNSTVPSLPDNNALFVTAAPPSGVPSSIR
What is the function of this protein?
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (By similarity).  Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (By similarity).  Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity).  Does not play a role in U8 snoRNA decapping activity (By similarity).  Binds U8 snoRNA (By similarity).
What are the official names of this protein?
Diphosphoinositol polyphosphate phosphohydrolase 2, DIPP-2, rDIPP2, Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2, Nucleoside diphosphate-linked moiety X motif 4, Nudix motif 4.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. DIPP subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAB2_BRAHO
Sequence: MIINNNISAINAQRTLKFRNVDLSKDMAALSSGMRINRAGDDASGLAVSEKMRTQIRGLRQAERNNSSGISFIQTTEGYLQESQDILQRIRELAVQSANGIYTDADRMLIQVEVSQLVDEVNRIASHAQFNTLNMLTGRFSNPNEGGAPVASMWFHIGANMDERRRVYIGTMTAAALGLQTAEGTGISISSIDKANSAIGIVDEALTKVSKQRSNLPAYQNRLELTAQGLMIAYENTAASESRIRDTDMAETSVKFAKDQILSQANLAMLAQANTMNQGALRLIQ
What is the function of this protein?
Component of the core of the flagella.
What are the official names of this protein?
Flagellar filament core protein flaB2, 34 kDa core protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Periplasmic flagellum. Periplasm.
Protein: PROA_CUPTR
Sequence: MTEFDLNQYMDRVGRQARAASRAIARASTADKNRALLTIAAAIRRDADQLKAVNARDVERARANGQDAAFVDRLTLSDKAIATMAAGLEQIAALPDPIGEISNMKFRPTGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEAIESNTALAALVAEGLSAAGLPPEAVQVIETTDRAAVGRLITMTEFVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDAEADLDKAVRVCDNAKTQRYAPCNTMETLLVSQDIAAAALPPLCRIYQQKGVELRVCPATRATLEAAGFSGLVDASEEDWRLEYLAPILAIKTVVGLDQAISHINEYGSHHTDSIITENYSAGMRFIREVDSASVMINASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVFGHGEVRT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PENJ_PENTH
Sequence: MSSTAQSFREIVGIPRSSASTQDSTLIIIDAQNEYATGALKVENVTETRKSIAKLLERYRQAGNGKNIVHVVHKVPEGAAVFTPNTPLAQEFEELTPNTGEKVVTKNFPSSFAKTDLHTYLQGLGDVGKKVVLVGYMAHVCVSTTTRAAAELGYDVLVVGDAVGDRDIPGVKVETLVSVVLSELADGFATVVSEEDIRA
What is the function of this protein?
Epoxide hydrolase; part of the gene cluster that mediates the biosynthesis of penigequinolones, potent insecticidal alkaloids that contain a highly modified 10-carbon prenyl group (PubMed:25859931).  The first stage is catalyzed by the nonribosomal pepdide synthetase penN that condenses anthranilic acid and O-methyl-L-tyrosine to produce 4'-methoxycyclopeptin (By similarity).  4'-methoxycyclopeptin is then converted to 4'-methoxydehydrocyclopeptin by the ketoglutarate-dependent dioxygenase penM through dehydrogenation to form a double bond between C-alpha and C-beta of the O-methyltyrosine side chain (By similarity).  PenM also converts its first product methoxydehydrocyclopeptin to 4'-methoxycyclopenin (By similarity).  The following conversion of 4'methoxycyclopenin into 4'-methoxyviridicatin is catalyzed by the cyclopenase penL (By similarity).  4'-methoxyviridicatin is the precursor of quinolone natural products, and is further converted to quinolinone B (Probable).  The prenyltransferase penI then catalyzes the canonical Friedel-Crafts alkylation of quinolinone B with dimethylallyl cation to yield dimethylallyl quinolone, which is subjected to FAD-dependent dehydrogenation by the FAD-linked oxidoreductase penH to yield conjugated aryl diene (PubMed:25859931).  The delta(3') double bond then serves as the site of the second alkylation with DMAPP catalyzed by the prenyltransferase penG to yield a carbenium ion intermediate, which can be attacked by H(2)O to yield a styrenyl quinolone containing a C3'-hydroxyprenyl chain, or undergo cyclization to yield yaequinolones J1 and J2 (PubMed:25859931).  The conversion of the styrenyl quinolone into the tetrahydrofuran-containing yaequinolone C is performed by the FAD-dependent monooxygenase penE and involves epoxidation of the terminal C7'-C8' olefin, followed by epoxide ring opening initiated by the C3' hydroxyl group (PubMed:25859931).  The predicted cysteine hydrolase penJ acts as an epoxide hydrolase that enhances the rate of the 5-exo-tet cyclization step, increasing the yield of yaequinolone C (PubMed:25859931, PubMed:28114276).  PenF catalyzes the cationic rearrangement of the epoxide formed by penE (before ring opening to produce yaequinolone C) into yaequinolone D (PubMed:28114276).  Finally, the short-chain dehydrogenase/reductase (SDR)-like reductase penD, catalyzes both the dehydration of yaequinolone D and the reduction of the resulting oxonium to yield penigequinolone (PubMed:28114276).
What are the official names of this protein?
Epoxide hydrolase penJ, Penigequinolones biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family.
Protein: DTX15_ARATH
Sequence: MREEREDMLSWPLIGEKEKRSRFVKEEVEKQLLLSGPLIAVSLLQFCLQIISVMFVGHLGSLPLSAASIATSFASVTGFTFLMGTASAMDTVCGQSYGAKMYGMLGIQMQRAMLVLTLLSVPLSIVWANTEHFLVFFGQDKSIAHLSGSYARFMIPSIFAYGLLQCLNRFLQAQNNVIPVVICSGVTTSLHVIICWVLVLKSGLGFRGAAVANAISYWLNVILLSCYVKFSPSCSLTWTGFSKEARRDIIPFMKLVIPSAFMVCSLEMWSFELLVLSSGLLPNPVLETSCPRTVWMIPFGLSGAASTRVSNELGSGNPKGAKLAVRVVLSFSIVESILVGTVLILIRKIWGFAYSSDPEVVSHVASMLPILALGHSLDSFQTVLSGVARGCGWQKIGAFVNLGSYYLVGVPFGLLLGFHFHVGGRGLWLGIICALIVQGVCLSLITFFTNWDEEVKKATSRAKSSSEVKEFAVDNGSILV
What are the official names of this protein?
Protein DETOXIFICATION 15, AtDTX15, Multidrug and toxic compound extrusion protein 15, MATE protein 15.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS5_TREDE
Sequence: MSHQKESKRDNQHTDKEYVEKLVKLNRTAKVVKGGRRFSFSALTVVGDQKGRVGYGFGKANDVSDAIRKSIEKAKANMVTFPLKNGTIPHEVQGKFKGSSVLLRPACSGTGIIAGGTIRAIMEAAGATDLLSKSLGSSSAVNVVKATFDAASLLMDGKKIAKSRGKTLLDVWG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: DNPH1_TETTS
Sequence: MSQKKLTIYFCGSMRGVNANHQNYQTIVQELSKYGEVLTTHVAYPEMSNKLEHKMNDKQIYERDYSWFTESQVMVAEVTAPSHGVGMELGWASLRQNYKTLCLSQKEKEFKTSGLIAGCPTFEYKEYQNQEDIVAIIAEFMKQLQ
What is the function of this protein?
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
What are the official names of this protein?
Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS8_LEPBP
Sequence: MSLSDPIADMLTRIRNAQQAKHELCVIPGSKIKKSILDLLKEEGFVDDVQTVKNGSFDDFQVKLKYDTEKKPVIRMIERVSTPGRRVYIQSGEIRPFRNNIGTLILSTSKGVMTGKRARKLRVGGEVLCKVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ISPD_BIFLD
Sequence: MTERDFDTPVETPTVQPAPAQGAKPAQTVPVVAVVLAAGFGTRFDPDNPKQLVSVGGKPIVCWSIDAFEHCDRVSDIVVVVNPKVRGEVETLVGEMGYTKVRVIIDGGDERVDSTAAALDMLATAGIPDDAKILIHDAVRPFVEQSAIDGSIDALDQFTAATVAYASTDTVLLTEDLGDLKVVKSVPDRPNTFRAQTPQSFRFATIRHAYDLAAADPDFHPTDDTRVVVDYLPDEPVAIVSGAETNLKITTLEDIPTAERIAEEILGRDPKEEARARMHALLAQAAGQMHR
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: ESF2_DEBHA
Sequence: MIQDESDLDDFEDDEEDDEDEKVFNISKKASHIDNFKNEESEDEEDLNEEDDDLFMNTDIIDEETIENSKQAKNINLKKLTPEQLAKEQKKIKKTGVCYLSKIPPYMKPAKLRSVLSRFGKIDRLFLKPEDNSTYTKRVKYGGNKKKNYTAGWVEFINKKDAKLCAGTLNGNKLGGKKSSYYYDDIINIKYLSAFKWFDLTQQIAKENEIRQAKLSMELSQQQKLNKSFINNVEKSKMINNMQNKRKARQAESGADNSNKEESDIRRNLKQRKLASTRADAEDELKHKSKPNEKLNDVLSKVF
What is the function of this protein?
Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis.  Required for the early cleavages at sites A0, A1 and A2 (By similarity).
What are the official names of this protein?
Pre-rRNA-processing protein ESF2, 18S rRNA factor 2.
What is the protein family that this protein belongs to?
Belongs to the ESF2/ABP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MURQ_EXISA
Sequence: MLDKLATERRNEQTMHLDEMSIEERLTIMNAEDHKVPQVIQEQLPVITQVVERVIASFRKGGRLIYIGAGTSGRLGILDAAECVPTFGVSPNQVIGLIAGGERALIQAVEGAEDSKELAVTDLKALHLTAEDTVVGIAASGRTPYVVGGLDYARELGATTASISCNRDAVISRHADYPIEVETGPEVLTGSTRLKAGTAQKLVLNMISTTSMIGVGKVYQNLMVDVQPTNEKLEVRAKRMIAEATGVDMEMAARYFASSKGHVKTAIVMILADVSYEEAVKRLERANGFVREAL
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: RL36_XANOM
Sequence: MKVLSSLKSAKTRHRDCKVVRRRGKVFVICKSNPRFKARQR
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: Y1244_CLOBB
Sequence: MEDRVEISMLMDFYSSLLTEKQRSVMALYYDDDLSLAEIAELNKTSRQAIHDLIKRCDKQLLSYESKLNLLQKSMRKEKYIMNFLEELKEKYSVSDKDYLMFKEKLENL
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein CLL_A1244.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: RAF1_XENLA
Sequence: MEHIQGAWKTLSNGFGFKESVFEGSSCMSPTIVHQFGYQRRASDDGKLSDTSKTSSTMRVYLPNKQRTVVNVRSGMSLHDCLMKSLKVRGLQPECCAVFRLIQDPKGKLRLDWNTDAMSLVGAELQVDFLDHVPLTTHNFVRKTFLKLAFCDICQKFLLNAFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNPNNIEGGSHTLPSLTMRRIGESVRIPVSSQQRYSTPHPFSFSTPSPVSECSLSQRQRSTSTPNVHMVSTTMAVDSRVIEDALRSHSESGSPNNLSPTGWSNAKAPAPTHREKAASSTGQEKNKIRARGQRDSSYYWEIIASEVMLSSRIGSGSFGTVYKGKWHGDVAVKILKVTDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYYHLHVLDTKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIRDRDQIIFLVGRGGVVPDLSKLYKNCPKAMKRLVADSIKKLRDERPLFPQILSSIELLQHSLPKINRSALEPSLHRAAHTEDISSCALTSTRLPVF
What is the function of this protein?
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions.  RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity).
What are the official names of this protein?
RAF proto-oncogene serine/threonine-protein kinase, C-RAF.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane.
Protein: VATD_DICDI
Sequence: MSGKNRLNIFPTRMALTVMKTKLKGAVTGHSLLKKKSDALTIRFRRILANIVENKQLMGTTMRDASFSLAAAKYAAGEFSNSVIENVSNPTIAVKMTTENVAGVHLPTFEKISEGVVSNSQELTGLSKGGQQINKSRESHIKAVEALIALASLQTAFITLDEVIKITNRRVNAIEYVVKPKLENTISYIITELDESEREEFYRLKKVQGKKKKDLKAKEAQKEENSANKTIMEPASVHKVRSLIDDEPEDAELLYED
What is the function of this protein?
Subunit of the peripheral V1 complex of vacuolar ATPase.  Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit D, V-ATPase subunit D, Vacuolar proton pump subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: BIOF_GLOC7
Sequence: MTNPYNWIEKSLETLHKANWYRSVKTIHSRSGSVVNLKGNLVINFASNDYLGLAGDERLINASIDAIKQYGTGSTGSRLLSGHRPIHRELENAIASFKQTEDAIVFSSGYLANLGTITALVGQRDLILGDEYNHSSLKNGSKLSGATVLDYEHGNLEDLNTKLVNYRRSYRRCLILTDTVFSMDGDICPLPQLLDLAEDFNCMVLVDEAHATGVMGKTGAGCVEHLNCSGRELIQMGTLSKALGSLGGYVAGSFQLVEFLRNRAATWIYTTGLSPGDTAAALTALNIIQAEPQRRQQLWENVGLLKEQLSGFNLFPSETPIICLGLNTPTEALILAQKLQDGGIFAPAIRPPTVPTSRIRFTLMATHQPCHFQRLGAVIR
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
Putative 8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: PUR9_CORGB
Sequence: MSDDRKAIKRALISVYDKTGLEDLAQALHRENVEIVSTGSTAAKIAELGIPVTPVEELTGFPECLEGRVKTLHPKVHAGILADTRKEDHLRQLKELEVAPFQLVVVNLYPFAETVASGADFDACVEQIDIGGPSMVRAAAKNHPSVAVVVSPNRYEDVQEALKTGGFSRAERTKLAAEAFRHTATYDVTVATWMSEQLAAEDSETEFPGWIGTTNTLSRSLRYGENPHQSAALYVGNIRGLAQAKQFHGKEMSYNNYTDSDAAWRAAWDHERPCVAIIKHANPCGIAVSDESIAAAHREAHACDSVSAFGGVIASNREVSVEMANQVAEIFTEVIIAPSYEEGAVEILSQKKNIRILQAEAPVRKGFESREISGGLLVQERDLIHAEGDNSANWTLAAGSAVSPEVLKDLEFAWTAVRSVKSNAILLAKNGATVGVGMGQVNRVDSARLAVDRAGAERATGSVAASDAFFPFADGFEVLAEAGITAVVQPGGSIRDNEVIEAANKAGVTMYLTGARHFAH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: HEMH_ECOL5
Sequence: MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALEMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSN4_CAEEL
Sequence: MSGEIERSQEVAVIFAQDTDHKAQYEALAKLCNKYLPQNAMGRVDTAEIIKIIDTVIALETGSMVVSRQFVSLITERLDNQHLESECVKAISEGILAIIKTRTISYEDQVCILRLMLASLYEKEGRIKDAAQALIAINSDTSPKFNGPQAAKEGAKAQLCIRITKLLLDCSEIDEAEQYVNRTSILMVDLGANPDIQIEHKALQARVSDAKRRFVEAAQRYYELSATEQLPNSDKLTALGKAIVCVLLAKPGPQRSRLLTLIFKDERAPKCASFELIAKMYLTKVIHKDELEEFEHQLQDHQKADEHGESILKGVIQEHNITAISQLYINISFKTLGQLLGVDTEAAESMAGEMISSERLHGYIDQTNGILHFEDSNPMRVWDSQILSTLEQINKVSDMIVARHSEFAEFLT
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF.  The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo.  Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
What are the official names of this protein?
COP9 signalosome complex subunit 4, Signalosome subunit 4.
What is the protein family that this protein belongs to?
Belongs to the CSN4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYC_SALSV
Sequence: MLKIFNTLTRQKEEFKPIHAGEVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLRFLGYKLKYVRNITDIDDKIIKRANENGESFVALVDRMIAEMHQDFDALNILRPDSEPRATHHIQEIIELTRTLIEKGHAYVADNGDVMFDVPTDPTYGQLSRQDLEQLQAGARVDVVDVKRNPMDFVLWKMSKEGEPSWPSPWGEGRPGWHIECSAMNCKQLGNHFDIHGGGSDLMFPHHENEIAQSTCAHDGEYVNYWMHSGMVMVDREKMSKSLGNFFTVRDVLKYYDAETVRYFLMSGHYRSQLNYSEENLKQARASLERLYTALRGTDKSAAPAGGEAFEARFVEAMNDDFNTPEAYSVLFDMAREVNRLKGEDMTAANAMASHLRKISGVLGLLEQEPDVFLQSGAQADDGEVAEIEALIQQRLDARKAKDWAAADAARDRLTEMGIILEDGPQGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.