Protein: PK1L1_ORYLA
Sequence: MFCLWIFSLAFLHLHLCSVSSSSLEGSGFFVGWINASSLQLFASIGGCDLSPCMDEGQEGMEALYRSEEPFQCSIRASASPGRRQAGRTCVRKVPGNLAVHCHLLSENEGLEEEDLLRITVMTPRGQSSLQVNVSHGGLLTACSDWIWNTSEKHKNNVPASGLHLGISLEVPCCTSCTRFGSDSELVEEQCSALHVSVSDVLVKDYICCLTPRDKDKTLNRTETPCLYSSNSLKDSLVRGRVYQMSFEECFRWHLLVVLLMLEAQYNHSQEVHEDPSSTVKLCDYAVRIHAEKQAYSTNTDIPLLAVVDILDPVEFLWDFGDFTSARANSRTITKRYTNPGIYKLVVVASWGQMSVRSHVLSLVVQRAVKLNRLVHEPSVLQNHTVTVSCRVNVGTNLTFLWNFGDGTVRTGLSTEQHVFTRTGEFRVMVIASNLVSSASLSSYLFVVDRPCQPPPVKNLGPPNIQVRRNEVVFLGVTFESELNCNVSRELHYSWTVYDSAGLTFPLPLTNTHRQSLVLQSYTLPYGIYKAIARVQIVGSVVYSNYSVRLQVVPNSVVVVIQGGTNIYVNTKSSNEVTLDGQASYDPDFPLNPLRYSWTCQPVSTISSSCFSQSIPTSYPVLKFPTSLLKSNFDQFKFTLTVHSGERSASSEIFLTLTSHLAGKLFVHCPECQGDQVSWDQSFSVRAECEDCNVSAEFIQYSWSLFRVNASSKPVAEIPFCYTVDLNAPSAVLENASTPTPAPEMSPSHHFNADWTRFTEDSLASSSPSRIYKSKNRNSELTDSPVSSVTVGFSGSESFNGPPGVDRGSSQFSNFPGQRDMFSEFQSDPESSAEWEFTFPYLESEDLRGQRGDSRVPFPRPEEGDPGISAGRPKETDMESFPSDSDSFSHSSSNKGEGSNLVDPRPSVRLQKPGLLDLHRDSVDKSLFESYTYTGISSCFLSFRSFSLKPSSTYMLELTAKSQRRFYGQTQLFLKVKPVPKGVACQVQPVRGIELYTHFSIFCTSGREDLIYTYSFSVGGRMPRILYQGRDFLYYFSLPSGDPTDDYKVIIYTEIRSSMYGSAKKLCPVTVRVEPSFVRNASSSYSHHEPDLMISDSGLRNVSVLVQLGNIAEIYNYISLLSTILNRLSLDSQANTHALKHLRNVLICIVCKLEYSAQASPADGIFILNELLRVTSQVTVQSARWVTAHVGALSVQFSESNRSILSALVSLLSSSLQVVTSSPETSDSADSPQPLESHLVTGKSRNAFVDDADHCITDLSETTYNKQSEPVPKRLMMRLVNDLLQTTSDLMLRNFDLQKTKELQVQSDLITLCAGFLNKTSTAINCGLITFFLPASLIKMLLLHDGISAKRGFSQREQPSCVQRIGMELLHNPYEWGRYPIQLKGPVADLSLYSCKTRRKIPVHSFLQPITVELRHPQKTSSMSEYTLLRSQINYHNFSITQEHLQQAVQVTVVFTAPPHMAFPVKILFRMFERPTPSMHHLHRLLNWRNNTILLTLPPSYLSAAGVGHLALLDANFGKTPTRRHLAEQISYSLTVESSLCLSWEDQQGSWTQNGCRAQTNDKTSAVNCSCHHLKPLKVLQQQIQSSHFRADLDQFLSVSRDLTVVFVLLLCVSLNIPVLVWCKKTDATSEENNRAHFLPDNSATDQHFYAVTVHTGLCSAARMSARVYVVLHGEDGCSQTKELHVPGCTLFRRNSQNTFILSVADSLGSVQGVHIWHNNSGPSPEWYLKQVQVSELMPGHMEGRSWQFISQCWLAVNKGDGQVERMLRVSTHGLTFSKMLFLKLFEYMPDYHIWMSVYTCPSPHLFTRAQRLCVCLLLFLGYACVNIIITHQRDDQLPFDLGVIDVTSVSIATGLVSVVAVLPVAMVISFLFRVKSGRMTLENYDNVFSKRPSGKTKYQDTDFLSVSTTNLENKDADDKEAVTPQRNKRRKDSVSFESIHELLFQEVLQVSRRRSLFLKKSKGNDSELSPQSSEFCGALKATKNEAQSVRVKRRYRLASLLYHCVAWTLCLLFCLSCLILSAVLGTRLNSGKILHWIHSLFVSLTFCFFVIHPATILVLAAVVSWRFKRSQDFHCFFNKMNSHLEDLKHQDPDQLRPSAFTRTRAPNAEKILEARQRARYLRRVHPPTRAELRKTRTKRKKQAVIHKMLRDLCLCGSMFFLMVCITYGSPVDEHYPLNAAFRRHFIRAHGDDFMSIKKYEDWWKWAQTSLLSSLYYNESENPQMSFISIGAPLVQKTEVCGTFHSQVSMVTPPRPRYHTGSSSKQEVTVGLGYTRSEGASKLRLLHLSGWLSEQTVALKVQFSLYSPAPNLFSSVTLLSEQSSTGLLQSSATVQSVRLYHSPSMLDYTVMVWQLLFLLLSLVNLYHQTSTAAQHGLMGYWKTTSISVEVSLVIVSLVYYVHYVYHPTMVMEVAEQLRRNHREHVDVSTLANSEQFSRTLRGIILFLLAVKCVTVVRLNRILAPSMPLLSLSSLLWPAISGLLLLSIFSCMGRLLYIERTFHSIQTVLWHFWSLRKSRDLISLWRDFYYFGLLYASSAMLTTMVFAVMIRKAKRSPSTKNDPTIREVLGCISQKFTGMKTQIPDCHTQKTYFLEECESLVDELLFKLNALSNSLHHTLPPKLHTYTDKDSPDASSTTELCKERLQDLVRSLSVGQGEAALTFPHDRSLLELQEEEEVKHQEGRCSVGCKESRLPETLWTADYRESMDEHWTEKKSSNGLGGATYSHVVVVEALVHHEQGTKN
What is the function of this protein?
Component of a ciliary calcium channel that controls calcium concentration within cilia without affecting cytoplasmic calcium concentration.  Forms a heterodimer with pkd2l1 in cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and gli2 transcription.  Does not constitute the pore-forming subunit (By similarity).  Also involved in left/right axis specification downstream of nodal flow: forms a complex with pkd2 in cilia to facilitate flow detection in left/right patterning.
What are the official names of this protein?
Polycystic kidney disease 1 like 1, Protein abecobe.
What is the protein family that this protein belongs to?
Belongs to the polycystin family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Multi-pass membrane protein.