PharMolix/UniProtQA huggingface dataset:
Protein: FGD_SEGRD
Sequence: MSLPIKLGYKASAEQFNPRELVEYTVAAERHGFDSVVVSDHFQPWRYTGGHAPWALAWLGAVGERTSRVQIGTSVLTPTFRYNPAIIAQAFATFGMLYPGRVFLGVGTGEALNEQAVGLKEWPEFKERFARLRESVELMRKLWTEERVNYEGEYYRTVDATVYDKPSEPIPVYVSAGGAVVARYAGRAGDGFICTSGKGAELYTETLLPAVQEGADKVGRDAGGIDKLIEIKLSYDPDPWLALNNTRFWSPLSLSAEQKHSLSDPKQMEEAADALPMEQIAKRWIVASDPDEVVEKIKFYTDLGLNHLVFHAPGHDQLRFLEVFERDLAPRLRSL
What is the function of this protein?
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone.
What are the official names of this protein?
F420-dependent glucose-6-phosphate dehydrogenase, FGD, G6PD.
What is the protein family that this protein belongs to?
Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family.
Protein: DTD_HAHCH
Sequence: MIGLVQRVAHACAKVNGEVIGSIDEGLLVLLAVEPDDTERKAERLLDRISGYRIFADPNGKMNLSLKDVGGELLVVSQFTLAADTKKGMRPSFSSAASPELGERLYDHFVEKASALLSRVQTGRFGAEMEITLTNIGPTTFSLRVE
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_I67A0
Sequence: MDSNTVSSFQDILLRMSKMRLGSSSEDLNGMITQFESLKLYRDSLGEAVMRMGDIHSLQNRNSKWREQLGQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLFEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: PRMA_THEPX
Sequence: MKWIEVQVTTTQEAEEAVTNIMHELGAGGVVIKNPNDVKLLAQSDNWDYLDSSLFEEEGNIKVFAYFPIASDTTDKINILKDRIVELKSFGIDIGNFDVKVSEVDEADWENNWKQYYKPLKIGKKIVIKPSWEEYVSQGEEIIIELDPGMAFGTGTHETTKMCLEFLEDIVMPESIVFDVGCGSGILSITSSKLGAKEVYAADIDEVSVEVARQNVELNNLQNVKVFKSDLLGEFRGKADIIVANIIADVIIRLSAEAPKYLKEEGLFLASGIIKSRKKEVMEKIQPFFEILQIKEEGEWCTILSRKK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_BARHE
Sequence: MKLTWIKCMSKTERISDIDEPRLFEENGVEAHIAAFVMPLLKPLGFRLVRVKLLGLNGLTLQIMVERPDGSMTVEDCETVSRTVSPLLDVQNVIERKYHLEISSPGIDRPLVRKSDFFHWQGHIAKIETKIILEGRRKFRGTLTNITQDGFTLNTDKAAYGESMYISIPFDDIIDAHLVLTDELIRDALKKNKDLSQQFISEDNQKLSKQERNYKN
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_RHOPS
Sequence: MASRQSPMAVSQPDHADRSAALQLTPVSRETERRLDAYLDLLRQWQAKTNLVAPSTLPQLWTRHVADSLQLLTLAPDARRWLDFGSGGGFPGIVLACAMAEHDGGHVTLVERNAKKAAFLREALRVTGSPGTVMLADIGDNVDRFPQGLDCITARAVAPLHQLIGFARPLMTEGSKALFLKGQDVEAELTEATRYWKIDPQLHASLTGGHGWIVEIDRIERQALPTASKEAAQ
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGB_SHISS
Sequence: MRLIPLTTAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPMTTYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKEHPESYYSFMHRNFFDHVDIPAENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVANSRFFDNDVNQVPKYALTVGVGTLLDAEEVMILVLGSQKALALQAAVEGCVNHMWTISCLQLHPKAIMVCDEPSTMELKVKTLRYFNELEAENIKGL
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: QOX3_STAES
Sequence: MSHDANTIDSRTHEGELNKLGFWIFLTAEFALFGTLFATLLTLQHGGGYGGKLTTDLFELHLILIMTFALLISSYTCGIAIYYMRQEKQNLMMFWMIITVILGLVFVGFEIYEFAHYASEGVNPTIGSFWSSFFILLGTHGAHVSLGIVWVICLLIQIGTRGLDSYNAPKLFIVSLYWHFLDVVWVFIFTAVYMIGMVYSG
What is the function of this protein?
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
What are the official names of this protein?
Probable quinol oxidase subunit 3, Quinol oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRUA_SYNP2
Sequence: MPMSQANPRKRIALVIQYIGTHFCGWQRQTAERTVQAVIEETISTVVGQKITIHGAGRTDSGVHAAGQFAHFECESLIPGYKWAKILNDRLPPDINIRGACEVSQDWHAQFSAQWRRYRYTIYTHPTPNLFIQPYAWHYYQAPLDETLIQAALTPLLGEHHLAAFQRTGSKRSHAWVNVQAAECSRRGSFIHIEIQANGFLYGMVRLLVGMLVDIGQGKLSLAQFQDIWKNEKRHLVKYSAPAKGLCLLRVGYPEPLFPPHIWFDTQPTFLLTH
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: DB133_HUMAN
Sequence: MKIHVFLFVLFFFLVPIATRVKCAVKDTYSCFIMRGKCRHECHDFEKPIGFCTKLNANCYM
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 133, Defensin, beta 133.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ABGX_LACLC
Sequence: MIKNHWMKKLKYLSLFFLLFAIYWFPDVILAYPEVYLKSLVGYERQVVATWIFLGNMSISLFLGILICYKLGYYKNTISIFKIKNLLFLLITTIILFVIYFFSYTYYNSHFITPGIAKTQAAFSIQIVFPFVQFITIAICAPIFEEASFRTTIYSFFKNDKIAYIVSCVGFAWMHTGPNPILIVYLPMSIVLTSIYHRRRVLGESILVHGVFNALLPIVIPLLQVITGLYYL
What is the function of this protein?
The function of this protein is currently unknown, but it has been shown that it is not necessary for phage resistance.
What are the official names of this protein?
UPF0177 protein in abiGi 5'region, orfX.
What is the protein family that this protein belongs to?
Belongs to the UPF0177 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CSK2B_ARATH
Sequence: MYRDRGTVNSRPEVVDRKRINDALERPSPSTSRQVNGKGKGTVTAATTTANLIGKQQSNNINHRDSRSASLSKNNTVSDDESDTDSEESDVSGSDGEDTSWISWFCNLRGNEFFCEVDDDYIQDDFNLCGLSSLVPYYEYALDLILDVESSQGEMFTEEQNELIESAAEMLYGLIHARYILTSKGLAAMLDKYKNYDFGRCPRVYCCGQPCLPVGQSDLPRSSTVKIYCPKCEDIYYPRSKYQGNIDGAYFGTTFPHLFLMTYGHLKPAKATQNYVQRVFGFKLHKP
What is the function of this protein?
Plays a complex role in regulating the basal catalytic activity of the alpha subunit.  The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor GBFl, resulting in stimulation of its DNA binding activity (PubMed:7696877).  CK2 phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis (PubMed:21330376).  CK2 phosphorylates translation initiation factors.  May participate in the regulation of the initiation of translation (PubMed:19509278, PubMed:19509420).  Stimulates the binding of CCA1 to promoters (Probable).
What are the official names of this protein?
Casein kinase II subunit beta-1, CK II beta-1.
What is the protein family that this protein belongs to?
Belongs to the casein kinase 2 subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: TPIS_LAWIP
Sequence: MKILIAANWKMNKNRLEAKDMIEKLMSMPEGIPPQRDIVLFPPFLAIDTIKEKLKNSTIVIGAQNFYPAPSGAFTGEISLEMLKDVGCSWVLIGHSERRHIIGELPTLIEQKTKLALSYGFSIILCIGETAQEREAGLVNSVLEQQLRTSLTDIPSKAISQLVIAYEPVWAIGTGKVASQQDIITAHTLIRKILHNMIGNTSQNIRILYGGSVNSENASSILELDNVNGLLVGGASLQAESFMKIIHAGFSE
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBB_LEIME
Sequence: MREIVSCQAGQCGNQIGSKFWEVIADEHGVDPTGSYQGDSDLQLERINVYFDESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRNRLAVNLVPFPRLHFFMMGFAPLTSRGSQEYRQGLSVADVTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKRFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEFDEEEEAY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GATC_GEOSM
Sequence: MKITREQVEHVARLARLELSEAELDTFTGQMDSILSYVEKLNALDTEGIVPTSHAVPMENAFRADEATGSIGVEAALANAPLRAESFFRVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: KMO_SALAI
Sequence: MNRRRERVVVVGAGLAGSLAALYLARQGHEVDIFERRPDPRSALAGPEGRSINLGLSARGMRALDGVGLLADVLKHSVPMRDRVVHSPDGGVRAQPYGVREHEILHSVLREELISLVVSAAEAEPGVRFHFDSLLTSLDRETGTVRVAPTAGGEASTVTADLVVGADGVFSTVRQQMQHGLRANYAQDFLPWGYKELTIPVGTDGQPRVRLEALHVWPGHEALMVAHPNRDGSLTCTLFMAHEGPVSFAALDTPAAVRDFFRRRFPDAEELMPDLVREITEHPVGHLVTVRTAPWRYADRVVLIGDAAHAVYPFYGQGMNSAFEDCVVLDECLTAHPDRAAALAAYEAARKPHTDVLADLSTANFEDLRDRVHRLGYSASAAADRLLARLLPQRWVPLYAMVAHTTIPYADALARANRQDRILRRAGAGLTLAVGLAATAAALRVGRRRRAARR
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Protein: EDEM1_MOUSE
Sequence: MQWRALVLGLVLLRLGLHAVLWLVFGLGPSMGFYQRFPLSFGFQRLRDPDGSGPVGPPGGPAWLHRPRRGTEGRLETPPEPGPTPGPGVCGPAHWGYALGGGGCGPDEYERRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIYCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIEDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDSNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQSYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDKSKEDRMESFFLSETCKYLYLLFDEENPVHKSGTRYMFTTEGHIISVDKRLRELPWKEFFSEDGERDQEEKFVHRPKSQELRVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI
What is the function of this protein?
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.  It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L.  It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
What are the official names of this protein?
ER degradation-enhancing alpha-mannosidase-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: PFKA_SULSY
Sequence: MKKIGLLTSGGDCPGLNACIRAVVRTANYYNIEVVAFKRGFKGLIENDFTTLDYKSVAGILQKGGTILLTAREPRFKDYNFRKIAYENIQKHNIEALFVIGGNGSFQGAYLLQKDFGLNIIGIPKTIDNDIYGTDYAIGFDTAVNNAMEAIDKIKDTTMSHERIFIVEVMGRDNGFIALEVGIAVGAELTLIPEYPFPLHVIEETILKAKEMGKNFAIIVLAEGVASAKELSEILNERLKDKDVGEIRYQVLGYIQRGGSPSAYDRVMASKFGVFAVEKFVQGEKNFMVAYENGKLLTKPLEISFNKVRIPNLEEYQINNILSM
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP4_BACAH
Sequence: MNWLEAFILGIIQGLTEFLPISSTGHLYLGRHLFQLDEAGLFLDTMLHIGTLLAVFIYYKKEFIYLIKNPFSKLMLLLIVGTIPAVVIGLLFKDFFEDISKTGITIGWEFLVTGFFLYMADKQKNGRKKMDDITYKDAFIIGSFQAAAIFPAISRSGMTIVAALWRKLDRETAAYFSFLLSTPAIVGAIILQFADVFQGKAESISNTSLIVGTLSAAFFGYIAVSWMIQYLKRHSLKVFAYYVWGLGIIIITLQYTHVF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 4, Bacitracin resistance protein 4, Undecaprenyl pyrophosphate phosphatase 4.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HS3S6_HUMAN
Sequence: MAGSGGLGGGAGGGQGAGAGQGAALRASRAPMLLVALVLGAYCLCALPGRCPPAARAPAPAPAPSEPSSSVHRPGAPGLPLASGPGRRRFPQALIVGVKKGGTRALLEFLRLHPDVRALGSEPHFFDRCYERGLAWYRSLMPRTLDGQITMEKTPSYFVTREAPRRIHAMSPDTKLIVVVRNPVTRAISDYAQTLSKTPGLPSFRALAFRHGLGPVDTAWSAVRIGLYAQHLDHWLRYFPLSHFLFVSGERLVSDPAGEVGRVQDFLGLKRVVTDKHFYFNATKGFPCLKKAQGGSRPRCLGKSKGRPHPRVPQALVRRLQEFYRPFNRRFYQMTGQDFGWG
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate.  The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry.  Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
What are the official names of this protein?
Heparan sulfate glucosamine 3-O-sulfotransferase 6, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6, 3-OST-6, Heparan sulfate 3-O-sulfotransferase 6, h3-OST-6.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: US03_HCMVA
Sequence: MKPVLVLAILAVLFLRLADSVPRPLDVVVSEIRSAHFRVEENQCWFHMGMLYFKGRMSGNFTEKHFVNVGIVSQSYMDRLQVSGEQYHHDERGAYFEWNIGGHPVTHTVDMVDITLSTRWGDPKKYAACVPQVRMDYSSQTINWYLQRSMRDDNWGLLFRTLLVYLFSLVVLVLLTVGVSARLRFI
What is the function of this protein?
Retains, but does not degrade MHC class I heterodimers in the endoplasmic reticulum during the immediate-early period of virus infection, thereby impairing their transport and maturation.  Forms a complex with beta-2-microglobulin-associated class I heavy chains, which accumulate in the ER.  In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
What are the official names of this protein?
Membrane glycoprotein US3, Glycoprotein E, Protein HQLF1, gpUS3 IE.
What is the protein family that this protein belongs to?
Belongs to the cytomegalovirus US2 family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: HISZ_BURP6
Sequence: MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGNELRLRTFKLVDQVSGRTLGLRADMTPQVARIDAHLLNRQGVTRLCYAGPVLHTRPRGLHASREQLQIGAEIYGHAGLEADQEIQQLMLDALHLTGLKKIRLDLCHAGVLAALFARDAAAAERGEALYEALAGKDVPRLNELTDDLGADTRAALRALPRLYGDASVLDDARRQLPALPEIARALDDLAHLAAQVKDAEVAIDLADLRGYAYHSGAMFAAYVDGVPNAVAHGGRYDHVGQAYGRARPATGFSLDLREIARISPVEARGAAILAPWKQDDALRAAVGALRDAGEVVIQALPGHDHVLDEFACDRALVERDGAWVIEPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y296_MYCGE
Sequence: MKPQLIAFKKFLQTEFQAVDFETFRINFNLCLKREQDNIVIYEDDDYDDQPFFFKPMLSDGFFIQTEVIKQLDYLAKVVENPKDSDQQCCQNFYEALIVFISALAITKGINPNRFHQRLVNRFAIHAVY
What are the official names of this protein?
Uncharacterized protein MG296.
Protein: TILS_BRUSU
Sequence: MGLSPVNIFKPFGLGRAKAVIAAVSGGSDSLGLLFLLKDYLSTLESPPVLIAVTVDHKLRAESALEAENVGLLCQKHGIMHCVLSWDDPKPAHGLAAAARTARYRLLVQAARDAGAGFIVTGHTENDQIETFLMRKARSGHCEARGLAAMSPRSLLEGSVKLARPLLTVSRQALRDELTRRGIAWVDDPSNANIDYERPRVRLGVAAEADGQEVLEQIAQAGAARERDNAALVEALADPATLGVDAAGMMFLNADCYAALSPGARQLFSGLLASIAGGRRFLPGDGERRRIERMLSGQDAPRRLTVFGALIERGEKGAPHRFRRERRNLPKLDLVPGQHIVWDGRFCFFNSGGRSFEIAPPGRQELIDFLKNSGRDIESRRCEALLISPALYEGGKLASVPFLPGAEWPQGVHIERHFAIFDHVLPGHDFALAQAVEARLGRACAEIS
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCC2G_HUMAN
Sequence: MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701).  In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701).  In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290).  It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.  In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type II subunit gamma, CaM kinase II subunit gamma, CaMK-II subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DNJB2_HUMAN
Sequence: MASYYEILDVPRSASADDIKKAYRRKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGTGTGPSRAEAGSGGPGFTFTFRSPEEVFREFFGSGDPFAELFDDLGPFSELQNRGSRHSGPFFTFSSSFPGHSDFSSSSFSFSPGAGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVTINGVPDDLALGLELSRREQQPSVTSRSGGTQVQQTPASCPLDSDLSEDEDLQLAMAYSLSEMEAAGKKPAGGREAQHRRQGRPKAQHQDPGLGGTQEGARGEATKRSPSPEEKASRCLIL
What is the function of this protein?
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199).  In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540).  Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695).  Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).
What are the official names of this protein?
DnaJ homolog subfamily B member 2, Heat shock 40 kDa protein 3, Heat shock protein J1, HSJ-1.
What are the subcellular locations of this protein?
[Isoform 2]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.