PharMolix/UniProtQA huggingface dataset:
Protein: MDM10_ARTOC
Sequence: MLDFMDYIQLAFSDASGWNRDNSYSTLTDTAKALLDFSTPERLRVHLSSLSTPQFATTYTLGTVGLIDGSVSYLFSTIPLDKTPSRSALISLRSLVPGYRQIYPPAVPLDLGLEWTLGSSGNTGAAEQALSNAYEDTGRSERKRKATLLHATLHLPPPTTLTALFLHRPSPTTKVSVALWSSQATNISKSASPQASILTQLFHDTGKYSTEFLFSTDNTLFGFRGLWNFGPDPRDSGGRNIATGNVKREKTSCPQSVALLSAGGEAYYSPTSSVIGLSTGVRFTTLPAAYDARSSSTSPPTLGGAGGSQIPSPISTFPYTLTLTLTPLTGSLSTTYSLLASPNLALSSRFGFNVYSWESEMVAGCELWRNRKKINLHNYNPDGSVDDLAWAKRKLGLLPPLESSDPASSSSSVSPTVSPVTSESVIKLRVDQSLRVRLLWEGRIKDLLVSAGVALGPTSAHTPSISCSGGSSSKGYSWTGVGVSVLYSS
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange.  MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex).  Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins.  Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins.  May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway.  Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 10, Mitochondrial inheritance component MDM10.
What is the protein family that this protein belongs to?
Belongs to the MDM10 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria- endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: MNME_LEVBA
Sequence: MAVTTTEFDTIAAISTPPGEGGISIIRLSGEEVFQVAAKLFKGADLTQVGSHTIHYGHILDPETGDEVDEVMVTVMRAPKTYTKEDIIEINCHGGIVATNRILQLCLSYGARLAEPGEYTKRAFLNGRIDLTQAESVMDLIRAKTDKSMKVALDQLDGDLSKLIRNLRQDILDALAQVEVNIDYPEYDDVETMTTKMLLEKAHEVKQQIKTLLATAKQGKVLREGLATAIVGRPNVGKSSLLNHLLHEDKAIVTDVAGTTRDVIEEYVNVKGVPLKLIDTAGIRDTTDKVEKIGVERSRKAINTADLVMLVLNASEPLTAEDEALLTATKDTQRILILNKTDLPLQLDLAAVRQVAGDSPIIETSILQSTGMDQLEETIAHLFFDEGIESSQNTVMVTNARHIGLLHQASAALDDVQNGIAAGMPVDLVQIDMTRAWDLLGEITGDSYQDELLDQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYC_DROME
Sequence: MALYRSDPYSIMDDQLFSNISIFDMDNDLYDMDKLLSSSTIQSDLEKIEDMESVFQDYDLEEDMKPEIRNIDCMWPAMSSCLTSGNGNGIESGNSAASSYSETGAVSLAMVSGSTNLYSAYQRSQTTDNTQSNQQHVVNSAENMPVIIKKELADLDYTVCQKRLRLSGGDKKSQIQDEVHLIPPGGSLLRKRNNQDIIRKSGELSGSDSIKYQRPDTPHSLTDEVAASEFRHNVDLRACVMGSNNISLTGNDSDVNYIKQISRELQNTGKDPLPVRYIPPINDVLDVLNQHSNSTGGQQQLNQQQLDEQQQAIDIATGRNTVDSPPTTGSDSDSDDGEPLNFDLRHHRTSKSGSNASITTNNNNSNNKNNKLKNNSNGMLHMMHITDHSYTRCNDMVDDGPNLETPSDSDEEIDVVSYTDKKLPTNPSCHLMGALQFQMAHKISIDHMKQKPRYNNFNLPYTPASSSPVKSVANSRYPSPSSTPYQNCSSASPSYSPLSVDSSNVSSSSSSSSSQSSFTTSSSNKGRKRSSLKDPGLLISSSSVYLPGVNNKVTHSSMMSKKSRGKKVVGTSSGNTSPISSGQDVDAMDRNWQRRSGGIATSTSSNSSVHRKDFVLGFDEADTIEKRNQHNDMERQRRIGLKNLFEALKKQIPTIRDKERAPKVNILREAAKLCIQLTQEEKELSMQRQLLSLQLKQRQDTLASYQMELNESRSVSG
What is the function of this protein?
Participates in the regulation of gene transcription (PubMed:8929412, PubMed:16087886, PubMed:24173801, PubMed:24615015, PubMed:25999153, PubMed:25858587).  Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG (PubMed:8929412).  Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth (PubMed:16087886, PubMed:25999153, PubMed:25858587).  Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex (PubMed:25999153).  Inhibits the demethylase activity of Lid (PubMed:17311883).  Activates transcription of mbm (PubMed:24615015).  Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1 (PubMed:25858587).  Able to induce the SCF E3 ubiquitin-protein ligase member archipelago (ago) which functions in its degradation (PubMed:15182669, PubMed:24173801).  It may therefore create a negative feedback loop with ago that is regulated by the ubiquitin hydrolase puf (PubMed:24173801).  In dopaminergic neurons, regulates dopamine levels by binding to the E-box (E1) of the dopamine decarboxylase Ddc promoter and thereby inhibiting its transcription (PubMed:35167135).  This regulation is required to suppress male-male courtship (PubMed:35167135).
What are the official names of this protein?
Myc protein, Diminutive protein, dMyc1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocation from the cytoplasm to the nucleus may be promoted by the TORC2 complex (Lst8 and rictor).
Protein: EX7L_NOCFA
Sequence: MTQDGSAPANSAEHPWPVRSVSVKVMQWIDRLGSIWVEGQITQINLRPGARTAFLVLRDPSADMSLQVTCDPELIRRSPVPLQEGSRVVVYGKLVFFPARGSISLRVLEIRPVGVGELLARIERLKALLAAEGLFDERLKRPIPFLPKVVGLITGRGGAAEHDVLTVARNRWPAVRFEVRNTAVQGPTAVPQILTALAELDRHPEVEVIVLARGGGSVEDLLPFSDEALCRAIVAATTPIVSAIGHEPDNPLSDYVADLRAATPTDAAKRVVPDAAAELALVRELRARSAAALRGWVDREARALAQLRSRPVLADPLREIDRRATEIERLRADARRCVRHLIRTESTATAHLREKLTAVGPAATLARGYAVVQRVTGPERHVVRSIADSPAGSQLRIRVADGAVSAAALGTTAAGTRIADDTGGN
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_PSEPK
Sequence: MDKLIITGGARLDGEIRISGAKNAALPILAATLLADGPVTVGNLPHLHDITTMIELFGRMGIEPVIDEKLSVEIDPRTIKTLVAPYELVKTMRASILVLGPMVARFGEAEVALPGGCAIGSRPVDLHIRGLEAMGAKIEVEGGYIKAKAPEGGLRGAHFFFDTVSVTGTENIMMAAALAKGRSVLQNAAREPEVVDLANFINAMGGNIQGAGTDTITIDGVERLDSANYRVMPDRIETGTYLVAAAVTGGRVKVKDTDPTILEAVLEKLKEAGADINTGEDWIELDMHGKRPKAVNLRTAPYPAFPTDMQAQFISLNAIAEGTGAVIETIFENRFMHVYEMHRMGAQIQVEGNTAIVTGVKALKGAPVMATDLRASASLVLSALVAEGDTLIDRIYHIDRGYECIEEKLQMLGAKIRRVPG
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y014_OSHVF
Sequence: MSKQRKSVTFFNNALDESPVETIFPMEKENKNRITPGLTELIETNMNLRRKCKLENCPKWDPNPDRARKVAYIQTLIVTQSSKLFMDEVDSFFNNRYVMSRDPTAQITVGKRMMGLTTMVVSGSLELELRLSKANKCVVCCKSGQPNNICDGCHEDVELVREVIDSLGMNYRNLFVTNDYDENDYESDIESIDV
What are the official names of this protein?
Uncharacterized protein ORF14.
Protein: U73C4_ARATH
Sequence: MASEKSHKVHPPLHFILFPFMAQGHMIPMIDIARLLAQRGATVTIVTTRYNAGRFENVLSRAMESGLPINIVHVNFPYQEFGLPEGKENIDSYDSMELMVPFFQAVNMLEDPVMKLMEEMKPRPSCIISDLLLPYTSKIARKFSIPKIVFHGTGCFNLLCMHVLRRNLEILKNLKSDKDYFLVPSFPDRVEFTKPQVPVETTASGDWKAFLDEMVEAEYTSYGVIVNTFQELEPAYVKDYTKARAGKVWSIGPVSLCNKAGADKAERGNQAAIDQDECLQWLDSKEDGSVLYVCLGSICNLPLSQLKELGLGLEKSQRSFIWVIRGWEKYNELYEWMMESGFEERIKERGLLIKGWSPQVLILSHPSVGGFLTHCGWNSTLEGITSGIPLITWPLFGDQFCNQKLVVQVLKAGVSAGVEEVMKWGEEEKIGVLVDKEGVKKAVEELMGASDDAKERRRRVKELGESAHKAVEEGGSSHSNITYLLQDIMQQVKSKN
What are the official names of this protein?
UDP-glycosyltransferase 73C4.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: PYRG_SYNR3
Sequence: MAKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYRVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTDTAMSRLNSVTTGSVYQSVINKERRGDYNGGTVQVIPHITGEIRERIHRVAANSNADVVITEIGGTVGDIESLPYLEAIREFRGDVGRNDLAYVHVTLLPYIGTSGELKTKPTQHSVKELRSIGIQPDILVCRSDRPIDDELKAKIGGFCGVPTKAVVPSLDADSIYAVPIALEKGGLCRQVLDVLSLQDHESDMASWEALVQKLRNPGPAVKVALVGKYVQLNDAYLSVVEALRHACIHCDSALDLHWICAEQIEENGADGLLKGMDAVVVPGGFGNRGVDGKIAAIRWAREQRVPFLGLCLGMQTAVIEWARNTAGLVGATSAELEPATTHPVIHLLPEQQDVVDLGGTMRLGVYPCRLSPGSKAHELYGEEVVYERHRHRYEFNNAYRNLFLESGYEISGVSPDGRLVELIELKGHPYFLACQYHPEFLSRPGRPHPLFTGLIQAASQRLPQSPSEAISQRA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: FABH_CHLCH
Sequence: MKAAITATANYLPPDILSNHDLELMLDTNDEWIRSRTGIGERRILKDPTKATSYMCGEVARQLLEKRQLAATDIELIIVATITPDMPFPATACLVQDLIGAKNAWAFDLNAACSGFLYALNTAIRFVESGAHKKVMVIGADKMSSIIDYTDRATAILFGDGAGGVLVEPAADDSCGVLDVRLYSDGTNGRERLLMTGGGSRYPASHETVDKKMHYIYQDGRQVFKAAVTAMADVATEIMQRNNLTADDVAYLVPHQANQRIIDAIAERMGVDRAKVVSNVGYYGNTTAGTIPICLAELDANNKLKHGDNLVLVSFGAGYTWGGIYVKWQ
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_ANADF
Sequence: MLRKAIADIQAKYVRKDVPELRSGDSVRVHTKIKEGDKERIQVFEGVVIAYRRGTPGSSMFTVRKMSYGVGVERMFPVHSPRIDRIEVTGHGEVRRSRLYYLRGLQGKAARLHQEEGPSSAAPASTPPAAAPQA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: AMT12_SOLLC
Sequence: MASAMTCSAAELFPHLGSSANATAAAEFICSRFSAVSEYLTNTTYAVDTTYLLFSAYLVFAMQLGFAMLCAGSVRAKNTMNIMLTNVLDAAAGGFSYYLFGFAFAFGAPSNGFIGKHFFGLKEFPSQAFDYSYFLYQWAFAIAAAGITSGSIAERTQFVAYLIYSSFLTGFVYPIVSHWFWSGDGWASASKTDGNLLLRFGVIDFAGSGVVHMVGGIAGLWGAFIEGPRIGRFDRSGRSVALRGHSASLVVLGTFLLWFGWYGFNPGSFLTILKSYDHTIRGTYYGQWSAIGRTAVTTTLAGCTAALTTLFCKRLLVAHWNVVDVCNGLLGGFAAITSGCAVVEPWAAIVCGFIAAWVLIGFNALAAKLKYDDPLEAAQLHGGCGSWGIIFTGLFAKKEYVNEVYPGFPNRPYGLFMGGGGKLLGAQVIQVVVIIGWVSVTMGPLFYLLHKFKLLRISRDDETAGMDLTRHGGFAYIYHDEDEGSSMPGFKMTRVEPTNTSTPDHQNRSVNVVV
What is the function of this protein?
Ammonium transporter probably involved in ammonium uptake from the soil.
What are the official names of this protein?
Ammonium transporter 1 member 2, LeAMT1;2.
What is the protein family that this protein belongs to?
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CY553_SPOPA
Sequence: GGGNDTSNETDTGTSGGETAAVDAEAVVQQKCISCHGGDLTGASAPAIDKAGANYSEEEILDIILNGQGGMPGGIAKGAEAEAVAAWLAEKK
What is the function of this protein?
Natural electron acceptor for a formate dehydrogenase.
What are the official names of this protein?
Cytochrome c-553, Cytochrome c553.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Note=May be released from the membrane upon cell disruption resulting in an abundant soluble form of the protein.
Protein: NCPP_ENT38
Sequence: MHQVVSATTNPAKIQAILRAFEEIFGEGSCHIEAVAVESGVPEQPFGSEETRAGARNRVLNAKALRSDADFWVAIEAGIDDGATFSWVVIENREQRGEARSATLPLPAIILEKVRAGEALGPVMSQYTGIDEIGRKEGAIGVFTAGALTRSSVYHQAVILALSPFHNAIYR
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: MRAZ_SHEB5
Sequence: MFRGASAINLDTKGRIAIPVRYREPLQLEHQGRIVITVDIQSACLLLYPIHEWELIEAKLLKLSDTDKTQRSLKRLLLGYAHEVELDGNGRILLPPPLRQYANLDKRIMLVGQLNKFELWDEQSWLQQIDECLETIRSEELASNERLADFSL
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ALF1_CHLTR
Sequence: MTTIFDLLGKDADYLLNHKCVIKKEALTLPSGDLVSRVFAESDRNNRVLRSLQQMFSCGRLGGTGYLSILPVDQGVEHTAGASFAKNPMYFDPENIVRLAMEAGCSAVASSYGVLSILARRYAHKIPFLLKLNHNELLSYPTTYHQIFFSQVEDAYNMGAVAVGATIYFGSESSSEEIVAVAEAFARARELGLATVLWCYLRNPHFVVNNVDYHTAADLTGQADHLGATLGADIVKQKLPTLQGGFKTINFSKTDDLVYSELSSNHPIDLCRYQVLNSYCGKVGLINSGGPSGQDDFAEAVKTAVINKRAGGMGLILGRKAFQRPFSEGVRLLNLIQDIYLDPTISIS
What are the official names of this protein?
Probable fructose-bisphosphate aldolase class 1, Probable fructose-bisphosphate aldolase class I, FBP aldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. FbaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_STAA9
Sequence: MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFSNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLINTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: RL16_DEIGD
Sequence: MLLPKRTKYRKQFRGRMTGDTKGGDYVAFGDYGLVALEPAWIKSNQIEACRIVMSRHFRRGGKIYIRIFPDKPVTKKPAETRMGKGKGAVEYWVSVVKPGRVMFEVSGVTEEQAREAFRLAGHKLPIQTKMVKREVYDEAQ
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: DRM3_ARATH
Sequence: MADMRRRNGSGGSSNHERNEQILFPKPETLDFDLPCDTSFPQQIGDNAASSSGSNVKSLLIEMGFCPTLVQKAIDENGQDDFELLLEILTKSTETEPPGPSFHGLMEPKPEPDIEYETDRIRIALLTMKFPENLVDFALDRLGKDTPIDEMVDFIVAAQLAEKYAEESEDSLDGAEINEEDEDVTPVTARGPEVPNEQLFETMDKTLRLLEMGFSNDEISMAIEKIGTKGQISVLAESIVTGEFPAECHDDLEDIEKKVSAAAPAVNRTCLSKSWRFVGVGAQKEDGGGGSSSGTANIKPDPGIESFPFPATDNVGETSRGKRPKDEDENAYPEEYTGYDDRGKRLRPEDMGDSSSFMETPWMQDEWKDNTYEFPSVMQPRLSQSLGPKVARRPYFFYGQLGELSPSWWSKISGFLFGIHPEHVDTRLCSALRRTEGYLHNLPTVNRFNTLPNPRLTIQDAMPHMRSWWPQWDIRKHFNSGTCSNMKDATLLCERIGRRIAECKGKPTQQDQTLILRHCHTSNLIWIAPNILSPLEPEHLECIMGYPMNHTNIGGGRLAERLKLFDYCFQTDTLGYHLSVLKSMFPQGLTVLSLFSGIGGAEIALDRLGIHLKGVVSVESCGLSRNILKRWWQTSGQTGELVQIEEIKSLTAKRLETLMQRFGGFDFVICQNPSTPLDLSKEISNSEACEFDYTLFNEFARVTKRVRDMM
What is the function of this protein?
Catalytically inactive DNA methyltransferase that acts as regulatory factor for DRM2-mediated DNA methylation.  Required for maintenance of non-CpG DNA methylation.  Required for normal establishment and maintenance of RNA-directed DNA methylation (RdDM) and accumulation of specific repeat-associated small interfering RNAs (siRNAs) (PubMed:21060858, PubMed:25316414, PubMed:25561521).  Required for nucleolus organizer region (NOR) nuclear organization during interphase (PubMed:25316414).  Acts downstream of the production of siRNAs.  May promote RNA polymerase V (Pol V) transcriptional elongation or assist in the stabilization of Pol V transcripts (PubMed:25561521).
What are the official names of this protein?
Probable inactive DNA (cytosine-5)-methyltransferase DRM3, Protein DOMAINS REARRANGED METHYLTRANSFERASE 3.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. DRM-methyltransferase family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with AGO4 in perinucleolar region.
Protein: TRM5_TRIV3
Sequence: MDIDPKDITISKEFQSIVVPKQLTGPVKAILQEKKLSATETKNVVDDPNGKRIILIPEVTELPKEVLEKVPEAKLEPYPVTLTYKQLTYIELLRHYIPEPLVIPTSFETIGHIAHLNLPDELLPYKKVIGECIILKNPCIKTVAIKQGPINNVYRNMELEVIAGKNDFITEVKQSGFTFKMDFSKVYWNSRLQYEHDSVVATFKENSLVCDAMCGIGPFAVRAAKKGCRVRANDLNPDSYYWLKENCKINGVSENVECFNMDAREFIRKQFDNGGCDYIVMNLPGTAVEFLDAIGEGAKKNRETARMPIVIFHSFDNKDGDYVASLRARAEKALGMKLPEMDIHNVRDVSPGKFMFRCTFSCADLFADEDDDKPHKVE
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
Protein: C71BG_ARATH
Sequence: MAISLLCLFLITLVSLIFVVKKIKHSKWDLPPSPPTFPVIGNLHQVGELPHRSFQRLAERTGHVMLLHFGFVPVTVISSREAAEEVLRTHDLKCCTRPKLVGSRLISRGFKDISFTPYGEEWRERRKFLVRELFCFKKVQYFGYIVEEECNLLVKKLTESAVGRPPVDLSKSLFWLAASILFRIAFGQSFHDNKFIDEDKIDELIFETETAQASFTCSDFFPIAGLGWLADWISGKHRWLNNVFFKLDALFQRVIDDHSDPGRWKDHKDIVDVMLDVMHKQGKDDSLRLTIDHIKGFLTNIIIAGIDTGALTMIWAMTELARNPELMKNVQGEIRDSFGNNKERITKEDLNKVPFLNMVIKETFRLHPVAPLLLPRETMTHIKVQGYDIPPKRRILVNTWAIGRDPTLWINPEEFNPERFINNPVDYRGQHFELLPFGSGRRICPGMGLGITIVELGLLNLLYFFDWRAPDGMTHKDIDTEEAGILTVVKKVPLKLVPVRVQ
What are the official names of this protein?
Cytochrome P450 71B16.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GNPI2_HUMAN
Sequence: MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGHLSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNKLVDPLFSMKDGN
What is the function of this protein?
Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.  Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P.  At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis.  Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling.
What are the official names of this protein?
Glucosamine-6-phosphate isomerase 2, Glucosamine-6-phosphate deaminase 2, GNPDA 2, GlcN6P deaminase 2, Glucosamine-6-phosphate isomerase SB52.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOG1_GIBZE
Sequence: MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSARDQLTNQNVAVKKIMKPFSTPVLAKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQPLRNKFKNADDSAIDLLERMLVFDPKKRITATEALAHDYLSPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVEAGVTNMEEQFNGQ
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes (By similarity).
What are the official names of this protein?
Mitogen-activated protein kinase HOG1, MAP kinase HOG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BTUD_SHISS
Sequence: MSIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFAMPVWHYLTLHQHDKTRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVRLAAVVLQITPQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAHRAWLLKGGKMLASGRREEVLTPPNLAQAYGMNFRRLDIEGHRMLISTI
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RBBP_ARATH
Sequence: MNAPIIDPLQGDFPEVIEEYLEHGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNDCSAAITSVSWSKYGHRLLVSAADKSLTLWDVSTGEKIARTILQQTPLQARLNPGLSSPSLCLACPLSSAPMIVDFDIDCTTLLPVSVPEMPDVLAPPQRSKCPESNPPFSPAAACFNKCGDLVYIGNSKGEILIVDYKSVRVLALVSASGAAPVKNIVFSRNGQYLLTNSHDRTIRIYENLLPAKNVLKSLEDLGKNIDGLDGIEKMKTVGSKCLTLFREFQDSVTKMHWKAPCFSGDGEWVVGGSACKGEHKIYIWDRAGHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIWAKDYTENWSAFAPDFKELEENEEYVEREDEFDLIPETEKVKVLDVNEDEEVDIDTVEKDAFSDSDMSVEELRYLPAEPIPDTNDQQDNLVESIKLIEGQISASPASEEAGQNGHHASSPQAEEMGETRGKRKRKPSEKAMELQAEKAKPLKGSGKTVRAKNRAAFDQETDDSINGGDDDDDAYY
What is the function of this protein?
Promotes the expression of FLC and FLC homologs to repress the floral transition (PubMed:21423667).  Promotes WRKY70 and LTP7 genes epigenetic methylation (e. g.  H3K4me3) and subsequent expression (PubMed:23284292).
What are the official names of this protein?
Protein RBL, COMPASS-like H3K4 histone methylation complex component RBL, RBBP5-like protein, AtRbBp5, Retinoblastoma-binding protein-like.
What are the subcellular locations of this protein?
Nucleus.