PharMolix/UniProtQA huggingface dataset:
Protein: HPRK_STREM
Sequence: MTVTVKMLVTKVKLDVVYATDDLLEKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVIVSRGLAIPEEMVQAAQEEGIALFSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVFAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVSIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEERLTRLISKNEEGK
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: BCAT1_RAT
Sequence: MAYLSRATATLARQDCSNGCSASYAEEEELEASTESYDEEGGSEASTQTFRAKDLIITKADVLKKKPDPSSLVFGASFTDHMLMVEWTSKYGWDKPHIKPFENLSIHPAASVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMKRMCRSAVRTTLPEFDKEELLQCVLQLIQLDREWVPYSTSASLYIRPTFIGIEPSLGVKKPSKALLFVILSPVGSYFSNGTFSPVSLWANPKFVRSWKGGTGDFKMGCNYGSSLLAQCEAAENGCHQVLWLYGKENRITEVGTMNLFLYWINKDGEEELATPPLDGVILPGVTRQSILELGEEWGEFKVCERHITMDDLSTALEENRVKEMFGSGTACVVCPVASILYKGQMLHIPTMENGHKLSSRIMAKLTDIQYGRIKSEWTLELP
What is the function of this protein?
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
What are the official names of this protein?
Branched-chain-amino-acid aminotransferase, cytosolic, BCAT(c).
What is the protein family that this protein belongs to?
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_BRUMB
Sequence: MTDIIRQLEAEQAAKIEEKRKLPDFQPGDTVRVQVRVTEGTRTRVQAYEGVCIARSGAGLNENFTVRKISYGEGVERVFPVYSPIVEGVEVVRRGKVRRAKLYYLRGLTGKAARIAEKKDNRTKAERAADKLAAAKAEAAKTAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: SYA_SHELP
Sequence: MYQTTAALRSAFLEFFRRNGHQVVDSSSLVPGNDPTLLFTNAGMNQFKDVFLGEDKRDYSRATTAQRCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKQDAIRFAWTFLTEELKLPKERLCVTVYETDDEAFEIWNKEIGVAAENIIRIGDNKGAAYASDNFWQMGDTGPCGPCTEIFYDHGEHIWGGRPGTPEEDGDRFIEIWNIVFMQYNRQADGTMDPLPKPSVDTGMGIERIAAIMQGVHSNYEIDIFQSLIKKTAEILGVTDLENKSLRVVADHIRSCAFLVADGVMPSNEGRGYVLRRIIRRAVRHGNKLGATEAFFYKLVPTLIEVMGDAAKELVATQAIVEKALKAEEEQFARTLERGLGILDNALSQLEGKELDGETAFKLYDTYGFPVDLTADVCRERDITVDEAGFEAAMAEQRSRAQAAGQFDTDYNDSLKIDAETEFCGYSDLNGEAKVIGLYVDGQAVDALAEGDQGVVVLDSTPFYGESGGQCGDKGLLSAEGVEFEVKDTQKYGQAMGHIGLVKAGSIAMGQTLNAAVDKKLRHRTELNHSVTHLLHAALRQVLGTHVSQKGSLVEPERLRFDFSHFEAVKREELKQVEDLVNTQIRRNHELKAEVMDIDQAKEKGAMALFGEKYDSQVRVVTMGDFSIELCGGTHVGRTGDIGLFKITSEGGIAAGIRRIEAVTGAAAIAYVGEQQAQLEQAASLLKGDSASVVAKLKAQLDKTKQLEKELSQLKDKLAAATSADLAGEAQELAGVKVLVKLLEGVEAGALRGLQDELKQKLQSGIVVLGIAGDAKVNLIAGVTKDLTGKVKAGELVAMVAAQVGGKGGGRPDMAQAGGSEPEKLAGALDSVIPWLSERLA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSGA1_OCEIH
Sequence: MNLNEFQQKYAYRKEINYDGQIDLLARVVMEQKERYILQTINGFKPAVVKGKMRHEAISREDYPAVGDWVVLQEKDFNDIVIIDQVLPRFSSIVRKVAGLRTDAQIVASNVTKVFIVISADEDLNERKLERYLTAVWESGASPHIVFSKVDLASDMDSIIEHADSIAFGIPLYKWNATNEEGKEDILANIHEDDSVVLIGSSGAGKSTLINALLTEKVLKTGSVREDDKRGRHTTTHRELFNLPTGGVIIDTPGMRELQLWTEDGDTLSHTFSDINHLIAECKFTDCKHDTEPDCAVKEALETGDLEEGRWNSYLKLQRELAYIERKQNAKLATEERKKWKKISMQQKKNR
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARP5_ORYSJ
Sequence: MSELLFETYGVPSIGNDTYLFVPLLSIVHGSFEVRIVDAKDVSSYFLKGEPVLGACCRTNVGGFHITDFLRQLLSLKYPYHSASITWEKAEELKKEHCYVALDYMSELQIFKNNKEEAEEKTRYWQLPWVPPPVEEPPSEEELARKAALKEKAGQRLRDMAAAKRSQKIAELEKQLSYLEELMEQLDGAEEEEATAILGRSGYLSQQEIKSAILKATQSLRKAKGESNGNEEKADASGVDKYPLVSVPDETLTPEQLKEKKKQILLKTTTEGRMRAKQRRAEEEALREKQEEERRLENPELYLEELRARYSELSDRVDQRKRQKLNGGKTNGNHNSSGGVGRGERLNAAQKERMRLLTSAAFDRGKGEDTFGTRDEDWLVYKKMSKDNDDDDDGNDDDESELARIASKIQDMDPTFVNKAEAVQQTPEPPKVRTLTAEDYRISIGIERFRCPEILFQPGMIGIDQAGIDEMVSISLRRLMEDEAVKERLCQSILVTGGCSLIPGMIPRLESGIRQFRPYLSPLKLVRAADPLIDAWRGAAAFAASSKFGRHTFSLADYREHGENLFHRYNIVYSL
What are the official names of this protein?
Actin-related protein 5.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYGB_LIMRD
Sequence: MANTYLLEVGVEEMPAHVVTPSIKQLHERVAKYLKEQRITFDDIQEFATPRRMALLIHGLSDKQPDIDESVKGPAKKIAQDADGNWTKAAIGFTRGQGASVEDIEFKEVKGVEYVFVEKHIAGKTVAEVLQGLPAVITSMTFPTLMKWGYNNLQFIRPIRWLVSLLNDEVVPFNILDVEAGRETQGHRFLGHPVEIAKADDYEETLNNDFVIADQTKRKNLIKDQITKIINENNWQVDWDEDLLEEVNNLVEWPTAFAGSFDEKYLALPDPVLITSMKDNQRFFCVRDGDGNLLSHFISVRNGNTDYLDNVIKGNERVLVPRLEDAQFFYQEDQKLTIDEYVERLKKVSFHDKISSMYDKMQRVAVIANVLGKQLNLSDEELADLDRAAHIYKFDLTTQMVGEFAELQGIMGEIYAKLFGEKDDVATAIREHYMPISAEGELPQTKIGAVLAIADKLDSIMSFFAVDMIPSGSNDPYALRRQAFGIVRIIADRGWHLPLLSIQSEIAPAFENAEINVSFDLNKNSDEVRSFFLDRIKQLFHGQKVRHDIIDAATDTRQNDIANILEAIQTIDDHKDDDNFKEDIEALTRVLRIAKKDKRPVSELVVDPNLFENPSEAKMHTAVSELIKENQQTVSENFAALRTLTPIISEYFDENMIMDKNEDIRNNRLAQLSILAHQASLIGNLDNLIVK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_MYCGA
Sequence: MSNKQITAVRGTTDWFDQAMILFNAISHKIIALSDLYTFQRIKTPVFEHAELFSRNLEHSDIVKKELYQLIDRSERKLALRPEGTASIIRAVNEHKLLDQNPWPLKLYYLEPMFRYERPQKGRMREFYQYGIELVGELDQLDYLQTILFAKKILDTFNFDCVLNINWLGNFASRKCWVEQLNQYFKQYQDQLSELSVSRLDSYGVLRILDDKNESKKDFVRSAPTIDQFISLEEQTQFKQLLEQLDQLGIKYKYNSSLVRGLDYYSELVFEFILANNDQAQSTLIGGGCYQNLIAELTNKPLKAIGFALSIERFISYLDDKTKDSLINQDQKPRYLLINLVPNKELATLNLSQELINHNYQVYYQHKLNKVDKAIKYALRAKFTHLIIMGNDEWSKQTMTIKDLSSQTQQTIKYKEFIK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_EDWI9
Sequence: MERITVTLGERSYPISIASGLFSQEAAFWPLRSGEQAMLVTNETLAKLYLAPVQRTLERAGVRVGQVILPDGEQFKSLSVLERVFSALLENNHGRDTTLVALGGGVIGDLIGFAAACYQRGVRFIQVPTTLLAQVDSSVGGKTAVNHPLGKNMIGAFYQPASVTIDIDCLQTLPLRELASGLAEVIKYGIIMDADFFRWLETQMDALLRLEPSALVYCIRRCCELKAQVVAEDEREQGRRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGTMMAARVACRLGYLQPQQAERMSALLTRAGLPVQGPAGMIPDAYLPHMLRDKKVLGGTLRLVLPTAIGSAEVFAGVSHDVVRDAIADCLA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SK1_PANSB
Sequence: EQFEDYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, PanS2-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRML_SYNY3
Sequence: MVKLVLVNPQIPPNTGNIARTCAATGTELHLVGPLGFELGDRYLKRAGLDYWPYVDLHYHNSCEEFITHWRGQGGNLLGFSVTGTVNFWDYTYQSTDWLMMGSETDGLPQMMRDLSTQLLCIPMPHSEVRSLNLASSAAIALFEAGRQLRSLG
What is the function of this protein?
Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
What are the official names of this protein?
Putative tRNA (cytidine(34)-2'-O)-methyltransferase, tRNA (cytidine/uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LFTR_BURPS
Sequence: MVPWLGPDDPFPSVERALGAASGAPGLLAASADLLPSRLIDAYRRGIFPWYSDGQPVLWWSPDPRMILVPAEFRISATFRKTLKRVLREPRWEIRVDCDFAGVMRACAQAPRRGQRGTWITAEIIDAYSSLHRAGDAHSIETWLDGRRVGGLYGVSFGRMFFGESMYAHASDASKIALAALVAHLREHRVEMIDCQQNTSHLASLGGREIARKTFVAHVRRAVAEPPIPWRFDKRVVAGLLGQAASATAADAFDR
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_GEOTN
Sequence: MSEIIHRSKTRPVRVGSLTIGGNNEVIIQSMTTTKTHDVDATVAQIHRLEEAGCQIVRVACPDERAADAIPEIKKRINIPLVADIHFDYKLALKAIEGGVDKIRINPGNIGRREKVEAVVKAAKERGVPIRIGVNAGSLEKRILEKYGYPTAEGMVESALYHIRILEELDFHDIIVSLKASDVRLAIEAYEKAARTFDYPLHVGITEAGTLFSGTIKSAVGLGAILSKGIGNTIRISLSADPVEEVKVAREILKTFGLASNAATLISCPTCGRIEIDLISIANEIEDYIAKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRHGKIVRKVPEEQMVEELKKEIDKLAEEYFAKQKEKEAALKGNAVE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: ECI3_MOUSE
Sequence: MPKPGVFNFVNKATWDARNALGSLPKETARKNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKNAISFQMYLDIMHALKNASTDNSVITVFTGTGDYYSSGNDLKNLINDAGEIQDVVATSTKILREFVNCFIDFPKPLVAVVNGPAVGIAVTILALFDAVFASDRATFHTPFSQLSQIPEACSTYMFPKIMGPTKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYSKLSPNVMRISKELIRKHEKQKLYTVNAEECAAALERMPREEYAKALRNFLFRKAKAKL
What is the function of this protein?
Catalyzes the isomerization of trans-3-nonenoyl-CoA into trans-2-nonenoyl-CoA (PubMed:24344334).  May also have activity towards other enoyl-CoA species (Probable).
What are the official names of this protein?
Enoyl-CoA delta isomerase 3, peroxisomal, Delta(3),delta(2)-enoyl-CoA isomerase, D3,D2-enoyl-CoA isomerase, Dodecenoyl-CoA isomerase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: MURB_ALKOO
Sequence: MDKLKAYKALTKVIPQDLVLLDEPMKNHTSFKIGGPADIMVIPETIDQLKSAIKLSKENQMPYFIIGNGSNLIVRDKGMRCIVIKIAEQFSKVSFQGNTVIAEAGILLSKLSKKIMAESLKGFEFASGIPGTLGGAITMNAGAYGGEMKDVVKGAHLLNDNGEVRYFTLEELELGYRTSIIQKQGYIALDVELALEKGDYQEILEITRDLTERRTTKQPLHLPSAGSVFKRPEGYFAGKLIQDSGLKGQRVGGAQVSELHSGFIVNVGDATAKDVLDLIQLIKDRVYETFHVQLETEVRIVGEE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLB_BACSU
Sequence: MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQTDDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDPPIPGHYKSVAIEITRKKS
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
What are the official names of this protein?
Dihydroneopterin aldolase, DHNA, 7,8-dihydroneopterin aldolase.
What is the protein family that this protein belongs to?
Belongs to the DHNA family.
Protein: COQ4_DROME
Sequence: MMQRCLRLQKPLALRRGLRLAQANSQAVATEAPEAEPLDAFERQYLKERIEISPFQRLFLGAGSSIAALLNPRRHDMIACLGETTGEDALWTILDTMQASEEGQRIMADKPRIHTSTIDFKYLETLPPDTFGAAYVKFLKDNQVTPDSRMAVRFLEDPKLAYLMTRYRECHDLIHTVLDMPTNMLGEVAVKWVEALNTGLPMCYGGAVFGAVRLRPKQRRAYLKHYLPWALENGKRTKPLMPVYWEKRWEQNIHELRSELGITVLNKA
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, Coenzyme Q biosynthesis protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: YQGF_CHRVO
Sequence: MAFDFGERRIGVAVGDTILGIPHPLATIDTAVTDERFAAIARLIEEWQPRQLVVGLPMHPDGEEHELSALSRRFANRLKGRFGLPVWLVDERYTSVIAEQLLEEAGVKKGRKQKPALDQVAAQAILAGWFEQPGTAV
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_RHIE6
Sequence: MAVYTDIAEDDLKWFLSEYDAGSLLSYKGIAEGVENSNFLLHTSKEPLILTLYEKRVEKTDLPFFLGLMQHLAARGLSCPLPLPRRDGALLGSLSGRPAALISFLEGMWLRKPEAKHCREVGRALAQMHVAGDGFELKRPNALSIDGWRTLWEKSEARADEVEPGLQHEIRGELDFLSAAWPKGLPAGVIHADLFPDNVFFLGDQLSGLIDFYFACNDLLAYDVSICLNAWCFEKDGAYNITKGTAMLEGYQSVRPLSGEEIAALPVLSRGSALRFFLTRLYDWLTTPEGAMVTKKDPLEYLRKLRFHRQIGSAAEYGLSL
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: YCGN_SALA4
Sequence: MADTLMSDIPFWQRKTLDEMTDAEWESLCDGCGQCCLHKLMDEDTDEIYFTNVACRQLNIKTCQCRHYERRFEFEPDCIKLTRENLPDFEWLPMTCAYRLLAEGKPLPTWHPLLTGSKAAMHGERISVRHIAVKESEVRDWQDHILNKPSWAE
What are the official names of this protein?
UPF0260 protein YcgN.
What is the protein family that this protein belongs to?
Belongs to the UPF0260 family.
Protein: RED2_MOUSE
Sequence: MASVLGSGRGSGGLSSQLKCKSKRRRRRRSKRKDKVSILSTFLAPFKYLSPGTTNTEDEDNLSTSSAEVKENRNVSNLGTRPLPPGDWARGSTPSVKRKRPLEEGNGGHFCKLQLIWKKLSWSVTPKNALVQLHELKPGLQYRMVSQTGPVHAPVFAVAVEVNGLTFEGTGPTKKKAKMRAAEMALKSFVQFPNAFQAHLAMGSSTSPCTDFTSDQADFPDTLFKEFEPSSKNEDFPGCHPVDTEFLSSAYRRGRLLYHTLDLMGQALPDRSRLAPGALGERNPVVVLNELRSGLRYVCLSETAEKPRVKSFVMAVCVDGRTFEGSGRSKKLAKGQAAQAALQALFDIRLPGHIPSRSKSNLLPQDFADSVSQLVTQKFRELTVGLTSVYARHKTLAGIVMTKGLDTKQAQVIVLSSGTKCISGEHISDQGLVVNDCHAEIVARRAFLHFLYSQLELHLSKHQEDPERSIFIRLKEGGYRLRENILFHLYVSTSPCGDARVNSPYEITTDLNSSKHIVRKFRGHLRTKIESGEGTVPVRGPSAVQTWDGILLGEQLITMSCTDKIASWNVLGLQGALLCHFIEPVYLHSIIVGSLHHTGHLARVMSHRMEGIGQLPASYRQNRPLLSGVSHAEARQPGKSPHFSANWVVGSADLEIINATTGKRSCGGSSRLCKHVFSAWWARLHGRLSTRIPSHGDTPSMYCEAKQGAHTYQSVKQQLFKAFQKAGLGTWVRKPPEQDQFLLSL
What is the function of this protein?
Lacks editing activity.  It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes.  Capable of binding to dsRNA but also to ssRNA (By similarity).
What are the official names of this protein?
Double-stranded RNA-specific editase B2, RNA-dependent adenosine deaminase 3, RNA-editing deaminase 2, RNA-editing enzyme 2, dsRNA adenosine deaminase B2.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFG_PROM2
Sequence: MARDFPLERVRNIGIAAHIDAGKTTTTERILFYSGVVHKIGEVHDGAAVTDWMAQERERGITITAAAISTSWQDHRINIIDTPGHVDFTIEVERSMRVLDGVIAVFCAVGGVQPQSETVWRQADRYSVPRMVFVNKMDRTGADFLKVNKQIKDRLKANALPIQLPIGAEGDLTGIIDLVANKAYLYKNDLGTDIEEAPIPSEMEEEAAEWRYKLMESVAENDEELIEIFLETGELSEEQLKKGIREGVLKHGLVPVLCGSAFKNKGVQLVLDAVVDYLPAPVDVKPIQGVLPSGKEDVRPSDDNAPFSALAFKVMSDPYGKLTFVRMYSGVLSKGSYVMNSTKDAKERISRLVILKADEREEVDELRAGDLGAVLGLKNTTTGDTLCNTDDPIVLETLFIPEPVISVAVEPKTKGDMEKLSKALTALSEEDPTFRVSTDPETNQTVIAGMGELHLEILVDRMLREFKVEANIGAPQVSYRETIRSSSKGEGKYARQTGGKGQYGHVIIEMEPAEVGKGFEFVNKIVGGAVPKEYIGPASNGMKETCESGVLAGYPLIDVKVTLVDGSFHDVDSSEMAFKIAGSMAFKDGVKKCNPVLLEPMMKVEVESPDDFLGSVIGDLSSRRGQVEGQSVDDGLSKVQAKVPLAEMFGYATQLRSMTQGRGIFSMEFANYEEVPRNVAEAIISKNQGNS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_PSEMY
Sequence: MSRNPFMQNMPEIQAAGGLVPMVIEQSARGERAYDIYSRLLKERVIFLVGQVEDYMANLICAQLLFLEAENPDKDIHLYINSPGGSVTAGMAIYDTMQFIKADVSTTCIGQACSMGAFLLAGGAKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAKEILFIRERLNELLAHHTGQSLETIERDTNRDNFMSAPRAVEYGIVDAVHEKRQMPV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHG07_HUMAN
Sequence: MSVAIRKRSWEEHVTHWMGQPFNSDDRNTACHHGLVADSLQASMEKDATLNVDRKEKCVSLPDCCHGSELRDFPGRPMGHLSKDVDENDSHEGEDQFLSLEASTETLVHVSDEDNNADLCLTDDKQVLNTQGQKTSGQHMIQGAGSLEKALPIIQSNQVSSNSWGIAGETELALVKESGERKVTDSISKSLELCNEISLSEIKDAPKVNAVDTLNVKDIAPEKQLLNSAVIAQQRRKPDPPKDENERSTCNVVQNEFLDTPCTNRGLPLLKTDFGSCLLQPPSCPNGMSAENGLEKSGFSQHQNKSPPKVKAEDGMQCLQLKETLATQEPTDNQVRLRKRKEIREDRDRARLDSMVLLIMKLDQLDQDIENALSTSSSPSGTPTNLRRHVPDLESGSESGADTISVNQTRVNLSSDTESTDLPSSTPVANSGTKPKTTAIQGISEKEKAEIEAKEACDWLRATGFPQYAQLYEDFLFPIDISLVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSDDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSHPKDGPSPGGTLMDLSERQEVSSVRSLSSTGSLPSHAPPSEDAATPRTNSVISVCSSSNLAGNDDSFGSLPSPKELSSFSFSMKGHEKTAKSKTRSLLKRMESLKLKSSHHSKHKAPSKLGLIISGPILQEGMDEEKLKQLNCVEISALNGNRINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSACNKRVGMYLEGFDPFNQSTFNNVVEQNFKNRESYPEDTVFYIPEDHKPGTFPKALTNGSFSPSGNNGSVNWRTGSFHGPGHISLRRENSSDSPKELKRRNSSSSMSSRLSIYDNVPGSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDNDRTTPSDLDSTGNSLNEPEEPSEIPERRDSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPLTLEALGHLGNDDSADYQHFLQDCVDGLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALLLTSVDHDRAPVVGVRVNVLLSRYLIEPCGPGKSKLTYMCRVDLRGHMPEWYTKSFGHLCAAEVVKIRDSFSNQNTETKDTKSR
What is the function of this protein?
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling.  This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation.  Also functions in vivo as an activator of the phospholipase PLCD1.  Active DLC1 increases cell migration velocity but reduces directionality.  Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433).  The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433).
What are the official names of this protein?
Rho GTPase-activating protein 7, Deleted in liver cancer 1 protein, DLC-1, HP protein, Rho-type GTPase-activating protein 7, START domain-containing protein 12, StARD12, StAR-related lipid transfer protein 12.
Protein: MTNB_PSEA7
Sequence: MNDNREQLTQQIIDAGRFLYGRGWSPATSSNYSARLDEGRALLTVSGRHKGQLGFDDVLATDLAGNSLEPGKKPSAETLLHTQLYAWSPAIGAVLHTHSVNATVLSRLVRGDRLVLQDYELQKAFAGVTTHEGQVEVPIFDNDQDIARLAGRVQPWLEAHPDCPGYLIRGHGLYTWGARMSDALRQVEAFEFLFECELKVLSLSR
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: GLYA_METTM
Sequence: MVSNQDYTERIRDLMKDHNSWMESSINLIASENITSSRVKEALISDLSHRYAEGLPGERLYEGCRYIDEIEEITIELSKKLFRAEHANVQPTSGVVANLACFFATADVGDPMMAMEVPYGGHISHAKVSAAGVRGFKIYTHPFDFENMNIDADAMKKKILEVKPRIILFGGSLFLFPHPVEEAVEAAEEVGARIMYDGAHVLGLIAGGYFQDPLREGADMLVGSTHKTFPGPQGGIILCREELADDIDEAVFPGLVSNHHLHHVAGLGIATAEMLEFGSEYAAQTIRNAKKLAENLNELGFNVLCEHLDFTESHQVVMDVSDIGRAAEISKKLEANNIILNKNLLPWDDVNRSDDPSGIRIGTQEITRRGMKESEMSEVAEYIKKVVIDGRNVKEEVSEFMSSYTKVHYAFEESGAYKYMEIL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.