PharMolix/UniProtQA huggingface dataset:
Protein: PFP_SPITD
Sequence: MTRISPLQKARYGYVPKLPPVLQDEIARIQAELGQPTEAVADREDLKRLFANTYGKPIATLTRGSNPEAGRRRTVGVILSGGPAPGGHNVICGLFDALKKANRESTLIGFKGGPSGILDDEWIEFTDSLINQYRNTGGFDIIGSGRTKIETPEQFAKALENAKKHGLDALVIIGGDDSNTNAALLAEYFVQQGAPIQVIGIPKTIDGDLKNEYIEASFGFDTATKVYAELIGNIARDAISSRKYWHFIRLMGRSASHIALECALQTHPNVCIVSEEVREKNMTLSQIVDQIVDAVVKRAAKGENFGVVLVPEGLIEFIPEVGALIDELNTLLAKEAEVFNRIDDPRERISWVKGKLSGNNQHVFSSLPETIQAQLLMDRDPHGNVQVSRIETEKLLIEMVSSRLKALKEEGAYKGKFSALNHFFGYEARCAFPSNFDADYCYALGFTAFVLIANGLTGYIAAIKNLARPAVEWKPMGIPLTMMMNMEKRHGKMKPVIRKALVDLEGAPFKRFATQRDAWATESAYVFPGAIQYYGPDDVCNQPTMTLKLEQGLE
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis.  Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.  Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
What are the official names of this protein?
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase, 6-phosphofructokinase, pyrophosphate dependent, PPi-dependent phosphofructokinase, PPi-PFK, Pyrophosphate-dependent 6-phosphofructose-1-kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPS1_STAS1
Sequence: MELQLAIDLLNKEEATILANKVKDYINIVEIGTPIVINEGLPAVQHLNDNIDGVKVLADLKIMDAADYEVSQAVKFGADIVTILGVAEDASIKAAVDEAHKHGKQLLVDMIAVQDLEKRAKDLDDLGADYIAVHTGYDLQAEGQSPLESLRKVKSVISNSKVAVAGGIKPDTIKDIVAENPDLIIVGGGIANADDPVEAAKQCRAAIEGK
What is the function of this protein?
Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate.
What are the official names of this protein?
3-hexulose-6-phosphate synthase 1, HPS 1, D-arabino-3-hexulose-6-phosphate formaldehyde lyase 1.
What is the protein family that this protein belongs to?
Belongs to the HPS/KGPDC family. HPS subfamily.
Protein: NEF_HV2CA
Sequence: MGASGSKKRSRPLQGLQERLLRARAGTCGECYNALEGESLRSQEGSDREQNSLSCEGQRYQQGDFMNTPWRAPAAEGKKNAYRQQNMDDIDSDDDDLVGVPATPRVPLRTMTYKLAVDMSHFIKEKGGLEGLFYSERRHRILDIYLEKEEGIIADWQNYTSGPGVRYPMFFGWLWKLVPVDTSQEGEDTETDTETHCLLHPAQTSRHDDMHGETLVWKFDSMLALKYEAFTRYPEEFGHKSGLPEDEWKAKLKARGIPFS
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Associates with the inner plasma membrane through its N-terminal domain.
Protein: CYB_RHIHI
Sequence: MTNIRKSHPLFKIINDSFIDLPTPSSISSWWNFGSLLGVCLATQILTGLFLAMHYTSDTDTAFHSVTHICRDVNYGWILRYLHANGASMFFICLFLHVGRGIYYGSYTFSETWNIGIILLFAVMATAFMGYVLP
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS82_ARATH
Sequence: MGISRDSIHKRRATGGKQKMWRKKRKYELGRQPANTKLSSNKTVRRIRVRGGNVKWRALRLDTGNFSWGSEAVTRKTRILDVAYNASNNELVRTQTLVKSAIVQVDAAPFKQGYLQHYGVDIGRKKKGEAVTTEEVKKSNHVQRKLEMRQEGRALDSHLEEQFSSGRLLACIASRPGQCGRADGYILEGKELEFYMKKLQKKKGKNAGAA
What are the official names of this protein?
40S ribosomal protein S8-2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: KLFL_DROME
Sequence: MDILPSGNIFSELERICTTGYYSSQPSIEDQWQQTCYELERYLRDEPKLQKKMHSNLDNPWDIFSTPARLLEELKIKEQHLDTISTTSSVSSNCSGTSWDSNGSQALSCSVLVKQERIDEEDDDVGCDDKLSVLLAAPPSAISPNPSIGSAGNMTPTSISNSSSISSSNSHSNSNGNTTGSSNIIASPLSSLGSGSTITVSSRNSSAPGIKVRVVQAKNHPGSNARMHLGHVQDFVLPTLTPPSSPESNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNSTPATAILRFTSQSNPTMTQLQQQQQQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNSSNSSSSSHSSSSSISGSSDQPTHSNIPRSTIVRLTTANGKPGAAGISLARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSANGSSKPHHPRQHHSDHSPDAKRRIHKCQFLGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRNCDRCFSRSDHLALHMKRHM
What is the function of this protein?
Probable transcription factor that is required for cell differentiation (PubMed:14527717, PubMed:24915236).  Essential for proper separation of the sister chromatids during early nuclear division cycles in the syncytial pre-blastoderm embryo (PubMed:24915236).
What are the official names of this protein?
Krueppel-like factor luna.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENO_PECAS
Sequence: MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGLAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQAVLGKDAKDQANIDKIMIDLDGTENKSQFGANAILAVSLAAAKAAAASKGLPLYAHIAELNGTPGKYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAIRMGSEVFHTLAKVLKSKGMGTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKSFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWAGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIDKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGDSAPFNGLKEVKGQ
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: TM139_HUMAN
Sequence: MVPMHLLGRLEKPLLLLCCASFLLGLALLGIKTDITPVAYFFLTLGGFFLFAYLLVRFLEWGLRSQLQSMQTESPGPSGNARDNEAFEVPVYEEAVVGLESQCRPQELDQPPPYSTVVIPPAPEEEQPSHPEGSRRAKLEQRRMASEGSMAQEGSPGRAPINLRLRGPRAVSTAPDLQSLAAVPTLEPLTPPPAYDVCFGHPDDDSVFYEDNWAPP
What is the function of this protein?
May be involved in cellular trafficking of proteins such as SLC4A1.
What are the official names of this protein?
Transmembrane protein 139.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ZN345_BOVIN
Sequence: MERLIKNSIAYSRFRGDWECKSQFERKQESQEGHLSQMIFTPEDMPTFNTQHQRIHTDEKLLECKECGKDFSFVSVLIRHQRIHTGEKPYECKECGKAFGSGANLAYHQRIHTGEKPYECNECGKAFGSGSNLTHHQRIHTGEKPYECKECGKAFSFGSGLIRHQIIHSGEKPYECKVCGKSFSFESALTRHHRIHTGEKPYECKDCGKAFGSGSNLTQHRRVHTGEKPYECKGCGMAFSSGSALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKAFRSGSKLIQHQRMHTGEKPYECKECGKAFSSGSDLTQHQRIHTGEKPYECKECGKAFASGSKLIQHQLIHTGEKPYECRECRKSFSSGSALNRHQRIHTGQKPYECKECEKTFGTGSTLTQHQRMHTAEKLYECKACGKALGRGSEIQQHKKNHAGEKLCELETP
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 345.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DXR_KITGR
Sequence: MVILGSTGSIGTQAIDVVLRNPGRFKVVALSAAGGAVELLAEQAVALGVHTVAVADPAAEEAAARGPGGQGAGRPLPRVLAGPDAATELAAAECHSVLNGITGSIGLAPTLAALRAGRVLVLANKESLIVGGPLVKAVAQPGQIVPVDSEHAALFQALAGGARAEVRKLVVTASGGPFRNRTREQLAAVTPADALAHPTWAMGPVVTINSATLVNKGLEVIEAHLLYDVPFDRIEVVVHPQSVVHSMVEFVDGSTMAQASPPDMRMPIALGLGWPDRVPDAAPGCDWTKAATWEFFPLDNEAFPAVELAREVGTLGGTAPAVFNAANEECVDAFLKGALPFTGIVDTVAKVVAEHGTPQSGTSLTVEDVLHAESWARARARELAAG
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: HOKC_SHIFL
Sequence: MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system (By similarity).  When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration (By similarity).  Its toxic effect is probably neutralized by an antisense antitoxin Sok RNA (By similarity).
What are the official names of this protein?
Protein HokC.
What is the protein family that this protein belongs to?
Belongs to the Hok/Gef family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: VP3_NCMV
Sequence: MSSKFGNQCGKTQKIYIRNELINPDIEFSVPNSIFSCIGPKYAYASLQSIVVKYTPVITERSTGSIGISVSDRRFSASEVVSNISLDTSSKANLMISGFSCCPLEEGCPYTITISTKLEGVNYGAAVGSLVVSPSFRLSNEPIPTTGITYQMIKLGDVQKTYQGVAITDEKK
What are the official names of this protein?
Protein 3.
Protein: HARB1_MOUSE
Sequence: MAIPITVLDCDLLLYGRGHRTLDRFKLDDVTDEYLMSMYGFPRQFIYFLVELLGASLSRPTQRSRAISPETQILAALGFYTSGSFQTRMGDAIGISQASMSRCVANVTEALVERASQFIHFPVDEAAVQSLKDEFYGLAGMPGVIGVADCIHVAIKAPNAEDLSYVNRKGLHSLNCLVVCDIRGALMTVETSWPGSLQDCAVLQRSSLTSQFETGMPKDSWLLGDSSFFLRSWLLTPLPIPETAAEYRYNRAHSATHSVIERTLQTLCCRFRCLDGSKGALQYSPEKCSHIILACCVLHNISLDHGMDVWSSPVPGPIDQPPEGEDEHMESLDLEADRIRQELILTHFS
What is the function of this protein?
Transposase-derived protein that may have nuclease activity (Potential).  Does not have transposase activity (By similarity).
What are the official names of this protein?
Putative nuclease HARBI1, Harbinger transposase-derived nuclease.
What is the protein family that this protein belongs to?
Belongs to the HARBI1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Interaction with NAIF1 promotes translocation to the nucleus.
Protein: POL_CAMVN
Sequence: MMNHLLLKTQTQTEQVMNVTNPNSIYIKGRLYFKGYKKIELHCFVDTGASLCIASKFVIPEEHWVNAERPIMVKIADGSSITISKVCKDIDLIIVGVIFKIPTVYQQESGIDFIIGNNFCQLYEPFIQFTDRVIFTKNKSYPVHIAKLTRAVRVGTEGFLESMKKRSKTQQPEPVNISTNKIENPLEEIAILSEGRRLSEEKLFITQQRMQKTEELLEKVCSENPLDPNKTKQWMKASIKLSDPSKAIKVKPMKYSPMDREEFDKQIKELLDLKVIKPSKSPHMAPAFLVNNEAENGRGNKRMVVNYKAMNKATVGDAYNLPNKDELLTLIRGKKIFSSFDCKSGFWQVLLDQESRPLTAFTCPQGHYEWNVVPFGLKQAPSIFQRHMDEAFRVFRKFCCVYVDDIVVFSNNEEDHLLHVAMILQKCNQHGIILSKKKAQLFKKKINFLGLEIDEGTHKPQGHILEHINKFPDTLEDKKQLQRFLGILTYASDYIPNLAQMRQPLQAKLKENVPWKWTKEDTLYMQKVKKNLQGFPPLHHPLPEEKLIIETDASDDYWGGMLKAIKINEGTNTELICRYRSGSFKAAERNYHSNDKETLAVINTIKKFSIYLTPVHFLIRTDNTHFKSFVNLNYKGDSKLGRNIRWQAWLSHYSFDVEHIKGTDNHFADFLSREFNKVNS
What is the function of this protein?
Encodes for at least two polypeptides: protease (PR) and reverse transcriptase (RT).  The protease processes the polyprotein in cis.  Reverse transcriptase is multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated, and reverse-transcribed inside the nucleocapsid.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA) (By similarity).
What are the official names of this protein?
Enzymatic polyprotein.
What is the protein family that this protein belongs to?
Belongs to the caulimoviridae enzymatic polyprotein family.
Protein: TMN11_ARATH
Sequence: MRSMDRFGIWVLAILLVIQSSFGFYLPGSYPHKYEVGDYLNVKVNSLTSIETEMPFSYYSLPFCKPSEGIKDSAENLGELLMGDRIENSPYRFRMFKNESEIFLCQTDKLSADSLKLLKKRIDEMYQVNPMLDNLPAIRYTKRDGYVLRWTGYPVGIKVQDVYYVFNHLKFKVLVHKYEEAANVARVMGTGDAAEVIPTIGKKDSDVPGYMVVGFEVVPCSFAHNGESTKKLKMYERYTTPIKCDSTRVSMSVKEGQSIVFSYEVSFEESDIKWPSRWDAYLKMEGSKVHWFSILNSLMVITFLAGIVLVIFLRTVRRDLTRYEELDKEAQAQMNEELSGWKLVVGDVFRAPSNASLLCVMVGDGVQILGMAVVTILFAALGFMSPASRGTLITGMLFFYMILGIAAGYVSVRLWRTIGCGEHRGWMSVAWKAACFFPGIAFLILTTLNFLLWGSHSTGAIPFSLFVILLLLWFCISVPLTLIGGYFGAKAPHIEFPVRTNQIPREIPAQKYPSWLLVLGAGTLPFGTLFIELFFIMSSIWMGRVYYVFGFLFVVLILLVVVCAEVSLVLTYMHLCVEDYKWWWKSFFASGSVAIYIFIYSINYLVFDLKSLSGPVSATLYLGYSLFMVLAIMLATGTVGFLSSFWFVHYLFSSVKLD
What are the official names of this protein?
Transmembrane 9 superfamily member 11, Endomembrane protein 6, Transmembrane nine protein 11, AtTMN11.
What is the protein family that this protein belongs to?
Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: T200A_HUMAN
Sequence: MIATGGVITGLAALKRQDSARSQQHVNLSPSPATQEKKPIRRRPRADVVVVRGKIRLYSPSGFFLILGVLISIIGIAMAVLGYWPQKEHFIDAETTLSTNETQVIRNEGGVVVRFFEQHLHSDKMKMLGPFTMGIGIFIFICANAILHENRDKETKIIHMRDIYSTVIDIHTLRIKEQRQMNGMYTGLMGETEVKQNGSSCASRLAANTIASFSGFRSSFRMDSSVEEDELMLNEGKSSGHLMPPLLSDSSVSVFGLYPPPSKTTDDKTSGSKKCETKSIVSSSISAFTLPVIKLNNCVIDEPSIDNITEDADNLKSRSRNLSMDSLVVPLPNTSESFQPVSTVLPRNNSIGESLSSQYKSSMALGPGAGQLLSPGAARRQFGSNTSLHLLSSHSKSLDLDRGPSTLTVQAEQRKHPSWPRLDRNNSKGYMKLENKEDPMDRLLVPQVAIKKDFTNKEKLLMISRSHNNLSFEHDEFLSNNLKRGTSETRF
What are the official names of this protein?
Transmembrane protein 200A.
What is the protein family that this protein belongs to?
Belongs to the TMEM200 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FOLD_STAEQ
Sequence: MVAKILDGKQIAKEYRQRLKNQVNDLKEYGFTPKLSVILVGNDGASQSYVKSKKKAAEKIGMISEIIHLDESTSEEVVLSELNRLNNDDTVSGILVQVPLPKQVSEQKVLEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADINLEGKNAVVIGRSHIVGQPVSKLLLQANATVTILHSRTKNMNAHLKQADVIVSAVGQPGLVTKENVKKGAVIIDVGNTPDENGKLKGDVAYDEIKEIASAITPVPGGVGPLTITMVLNNTLLAEKLRRGLTK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: MNME_BURO1
Sequence: MLATDSDPIVAIATAAGRGGIGVVRVSFGRGGEAAALPLIDALCGQKLAPRHASYVPFLDAHGAPLDRGIALYFPAPHSYTGEHVLELQGHGGPIVMQLLLQRCLDAGRGFGLRLAEPGEFTRRAFLNDKLDLAQAEAVADLIEASTEAAARSAGRSLDGAFSRQIHALVDDVITLRMLVEATLDFPEEEIDFLEAADARGKLAKIRAQLAHVLGDARQGALLREGLSVVLAGQPNVGKSSLLNALAGAELAIVTPIAGTTRDKVAQTIQVEGIPLHIIDTAGLRETEDEVERIGIARTWSEIERADVVLHLLDSRTGMTADDETIAARFPAGVPVVRVLNKTDLTGVPACVEHPAAEGDLTEVHLSAKRGDGIDMLRAELLRIAGWQAGAEGVYLARERHLIALRAAQEHLAQAANHAEQRAQSLDLFAEELRLAQEQLNAITGEFTSDDLLGVIFSRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
Protein: SET2_KLULA
Sequence: MTESGNGIVNTRQPKLFLDVPDMTSEAKKTYAELDVCTYTPKNLGDSKHEFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCEEPNCIGFLGGKTQTDAASLLPQSFADALGIRPSMEKKWINMMKAKGEKIAKSDTTTVNVDFVNSLSLEPCTKTEDVNRVMSVLLQIDDAFIAEKLLERITLTEDEAMHYQFIKLHGYLIFSRLITMFEDKPDIIWKILNFLLVLPKTTKNGIIHSGIDKKVEQLKNTPKFEVICEDLLEKWSKYETYTRISKKDISENSKVIDLRRIRLPIGWEIIHENGRPVYYNAQRQIKQANPPTDSAYRSNSSHNLSGVSDPKSRSATPSSNTSRYSGSVKYIPTPTYGQMQQKRTLSPEEYEKRKKSRIEWEQKELELRKLMEQETLKAKLDQETQKKSELERIIEEANKQKELERLQKLKQQQEDEERKKVKKQASHVNAIENKWVKFFAQHVPNLIKNYQKDVGKDVLKESARNIVKSLAQKELKKDSSRSPPEELSKEKRAKVKTFSMQYMDRLVAKMKEKKEKKR
What is the function of this protein?
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3.  Involved in transcription elongation as well as in transcription repression.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-36 specific, SET domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ASTRA_HUMAN
Sequence: MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPDDSFS
What is the function of this protein?
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity).  Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity).  Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity).  In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity).  At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).  May play a role in tumor progression (By similarity).  Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192).  This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192).
What are the official names of this protein?
Protein Aster-A, GRAM domain-containing protein 1A.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle, autophagosome. Note=In lipid-poor conditions localizes to the ER membrane and is recruited to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM (By similarity). Localizes to distinct EPCS than GRAMD2A and ESYT2/3 (PubMed:29469807).
Protein: ENT2_ARATH
Sequence: MDTSILAVTTNPKGKNYALAVCWLLGVGCLLAWNSMLTIVDYYAYLFPWYHPSRILTIIYQSFSIGALSVLVHKEARLNTRRRNLFGYSLFSLGSLAVLVLNLATSGRGGIGSFIGVCVISAAFGLADAHVYGGMIGDLSMMTPEFLQSFLAGLAASGALTSGLRLVIKAAFKNSRDGLRKGATLFFAMSASFELVCVLLYAYVFPRIPVVKYYRAKAIIQGSRTVWADLAAGGIQVQPITQDEEALRYDHRLNKGDLMLLYSDLAVTLFLVYLLTFSIFPGFLSEDTGKYSLGDWYALVLIAVFNVSDLVGRYVPMVKKLKMKSRKCLLITSLGRLLLIPAFNITGIYGSQGWMIFLMSVLGLSNGYLTVCVITSAPYDLLAPEQNALGNLLVLYICGGMFAGVACDWLWLVGKDW
What is the function of this protein?
May be involved in nucleoside transport.
What are the official names of this protein?
Equilibrative nucleotide transporter 2, AtENT2, Nucleoside transporter ENT2.
What is the protein family that this protein belongs to?
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Plasma membrane.
Protein: F209A_HUMAN
Sequence: MWTLKSSLVLLLCLTCSYAFMFSSLRQKTSEPQGKVQYGEHFRIRQNLPEHTQGWLGSKWLWLLFVVVPFVILQCQRDSEKNKEQSPPGLRGGQLHSPLKKKRNASPNKDCAFNTLMELEVELMKFVSKVRNLKRAMATGSGSNLRLRKSEMPADPYHVTICEIWGEESSS
What is the function of this protein?
May play a role in sperm acrosome biogenesis.
What are the official names of this protein?
Protein FAM209A.
What is the protein family that this protein belongs to?
Belongs to the FAM209 family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass type I membrane protein.
Protein: GLYA_METTP
Sequence: MSLLDHVDPEISAVIRKELDRQRNTLVLVAAENFTSPAVMEAQGCVMTNKYAEGYPGKRYYRGCAFMDEAENLARDRCKKLFGAEHVNVQPHSGSQANMAAYFATLKPGDTIMGMNLDHGGHLSHGSPVNFSGKLYHVVPYGVSRKTEMLDYSEILDVARECRPQMIVCGASAYPRIIDFKAMREIADEVGALLMADIAHIAGLVAAGVHPSPIPYADIVTTTTHKTLRGPRGGVIMCREELAQAIDRAVFPGIQGGPMMHTIAAKAVAFKEAMTPEFRRYQEQIVRNAAALADRLIENGFDLVSGGTDNHLMLVKLLKEGITGKEADETLESAGIALNKNMIPFDPRTPFVTSGIRIGTPAVTSRGMKENEMREIADLITEVIRDMKNPATIESVRSRVRALCERFPLYPELG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_LEGPH
Sequence: MSHNAPLVLMILDGWGYNENDRYNAIAKANTPQWDEWWQTCPHILLKASGLPVGLPDEQMGNSEVGHMHIGAGRVIQQDFTRINEAINNGKFAKNAVFHEVIDQLKKTEKSLHIMGLLSPGGVHSHEQHLFALLALCNQKKFRSVHLHLFLDGRDTPPQSALDSLKCLNEELAKHPVATINSICGRYYAMDRDKRWERVEPVYNLLTQGKSERQFPDAETAIHFYYKNKISDEFVPPTLIGKEHSIQDGDAVLFFNFRADRARQLTSTFLDPSFKGFERKTLPKLSYFVSMTQYDKNLLTTTAFPPVPLNNTLGEVLSSHGLSQLRIAETEKYAHVTFFFNGGCESVFTNEERIMVPSPQVATYDLQPEMSAHELTKTLIAAINSQDYHVIICNYANADMVGHTGNFEATVQAIECLDQCMQQVWQALKNNGGKLLITADHGNAEEMFSEATNQAHTAHTSEPVPFLYVGGGWHFTHSEGSLIDIAPSLLALLGITPPPEMTGRILLEKNHAHP
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.