PharMolix/UniProtQA huggingface dataset:
Protein: DAPB_JANMA
Sequence: MNQLKIAVAGASGRMGHMLIETILEAQDATLTGALDIAASPAVGSDAAAFLGKPAGVLIESDFAKGLANSEFLIDFTRPEGTLQHLEYCAAHNIKMIIGTTGFDAAGKAAIAAAAEKTAIMFAPNMSVGVNVTMKLLEMAAKNFSEGYDIEIIEAHHRHKVDAPSGTAIKMGEVIAGALGKELNDVAVWAREGVTGARDPSSIGFATVRGGDIIGDHTVLFAGIGERIEISHKSSSRVSYAHGSLRAARFLADKKTGLYDMQDVLGLR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX3_GAZSU
Sequence: MTHQTHAYHMVNPSPWPLTGALSALLMTSGLIMWFHFNSTTLLMLGLTTNMLTMYQWWRDVIRESTFQGHHTPNVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGINPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMLQALFITIALGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RAD18_CANAL
Sequence: MNLKDITDPSDFKTTKLPALAELDILKRCYICKDLLNAPVRTQCDHTYCSQCIREFLLRDNRCPLCKTEVFESGLKRDPLLEEIVISYASLRPHLLRLLEIEKVESKQEVDREKSANESASNGNRNVNNDVDETVRVKDQSNADELGEEKGQAQHGEQVNEQTTEVISLLSDDEENGSDSLVKCPICFERMELDVLQGKHIDDCLSGKSTKRTPTDILSPKAKRPKQITSFFKPTIDTKTPSPPTSKASTTPTATPTTTLLKANVSSPSPVAQSTVHKGKPLPKLDFSSLSTQKIKAKLSDLKLPTTGSRNEMEARYLHYYVIYNANLDSNHPVKESILRQQLKQWEMVQHQPSFGDAEWKGAETGNWKELIARARSN
What is the function of this protein?
E3 RING-finger protein, member of the UBC2/RAD6 epistasis group.  Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
What are the official names of this protein?
Postreplication repair E3 ubiquitin-protein ligase RAD18, RING-type E3 ubiquitin transferase RAD18.
What is the protein family that this protein belongs to?
Belongs to the RAD18 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ICP18_FRG3G
Sequence: MRMIQAYLCDSVSGEPYTCKGDLCEIPFNRNFTIDLVNLSVSTEFQVKITMTPHHDLGTFVVEPKNVFSIKRAVKGDAAFKVERAAGWLPDTPQVLTLFVYERLNPVEWHSECMYENLETDGGTVIVPGEATGQRFGTATEVPTMFLFKRMFVVKGV
What are the official names of this protein?
Immediate-early protein ICP-18.
Protein: ODO2_ECOLI
Sequence: MSSVDILVPDLPESVADATVATWHKKPGDAVVRDEVLVEIETDKVVLEVPASADGILDAVLEDEGTTVTSRQILGRLREGNSAGKETSAKSEEKASTPAQRQQASLEEQNNDALSPAIRRLLAEHNLDASAIKGTGVGGRLTREDVEKHLAKAPAKESAPAAAAPAAQPALAARSEKRVPMTRLRKRVAERLLEAKNSTAMLTTFNEVNMKPIMDLRKQYGEAFEKRHGIRLGFMSFYVKAVVEALKRYPEVNASIDGDDVVYHNYFDVSMAVSTPRGLVTPVLRDVDTLGMADIEKKIKELAVKGRDGKLTVEDLTGGNFTITNGGVFGSLMSTPIINPPQSAILGMHAIKDRPMAVNGQVEILPMMYLALSYDHRLIDGRESVGFLVTIKELLEDPTRLLLDV
What is the function of this protein?
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: YL257_YEAST
Sequence: MVDARGSTPCLIGDSIRNVNDGNSLDFQYTNQFNEESEASRLLTPQTSSNHALSKMQKDDDIRDRSYTSVAELNREGALLTDEVDLENVDASKVRSNRDDLEAEEKRKKLLLLKKKQRNKSINSESFSSPSLRASKSNSLITSTDPVEDHISKYSSSGTPENITGEADDEDEDIIRNSYGQMIKNNSNRPHLAKGESYQSAEQEIDHTAPEKSEKRQERSGRSFDRQKSSAEFLRSLSRSISRGPTKNKTVSPSKGEDSRMYSTSNYSISLVDLENGPKIIPETLEEEQEDAEKEGVLMEDEGNEEYTKDLEEAANKAQPQ
What are the official names of this protein?
Uncharacterized protein YLR257W.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_ECO27
Sequence: MRPAGRSNNQVRPVTLTRNYTKHAEGSVLVEFGDTKVLCTASIEEGVPRFLKGQGQGWITAEYGMLPRSTHTRNAREAAKGKQGGRTMEIQRLIARALRAAVDLKALGEFTITLDCDVLQADGGTRTASITGACVALADALNKLVENGKLKTNPMKGMVAAVSVGIVNGEAVCDLEYVEDSAAETDMNVVMTEDGRIIEVQGTAEGEPFTHEELLTLLALARGGIESIVATQKAALAN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: NUDC_SALPK
Sequence: MDRIIEKLESGWWIVSHEQKLWLPYGELPHGLAANFDLVGQRALRIGEWQGEPVWLVLQHRRHDMGSVRQVIDQDAGLFQLAGRGVQLAEFYRSHKFCGYCGHPMHPSKTEWAMLCSHCRERYYPQIAPCIIVAIRREDSILLAQHVRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGEIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYD
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.  The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing.  Has preference for mRNAs with a 5'-end purine.  Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
What are the official names of this protein?
NAD-capped RNA hydrolase NudC, DeNADding enzyme NudC, NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
Protein: MP8_PMVK
Sequence: MSTVETPAQDTLATKEPNKTGAKDRQQARSARLSVAAGAGRTALSQRDAQEDRFSLGIVQTADKIENTFNFNF
What is the function of this protein?
Cell-to-cell movement.
What are the official names of this protein?
Probable movement protein p8.
What is the protein family that this protein belongs to?
Belongs to the carmovirus/necrovirus/panicovirus movement protein p8 family.
What are the subcellular locations of this protein?
Host cell wall.
Protein: SC61A_DICDI
Sequence: MGFRFLDIVKPFTSLVPEVGQPDRKIPFREKVLWTAICLFIFLVCSQIPLYGIRSTDSSDPFYWAKVIMASNRGTLMELGISPIVTSGMVMQLLAGAKLIEIDQSVKADRDLFSAAQKLFGMLICVGQGVAYIWSGSYGDPAVLGFGNCFLIVLQLFFAGIIVMLLDELLQKGYGIGSGISLFIATNICETIVWKTFSPTTVSVGKGTEFEGAVIALFHLLLTRNDKVRALKEAFYRQNLPNITNLLATVLIFMVVIYFQGFRVDLPVKSTRVSGQQGTYPIKLFYTSNIPIILQSALVSNLYFISQLLYRRFPDNILVNLFGAWRTSEYSQQMIPVSGLTYYISSPNNMSAVLADPFHALFYITFMLTSCALFSKVWIEVSGSSARDVAKQLKDQQMTMKGHRDTSVIKELNRYIPTAAAFGGLCIGALTVVADFMGAIGSGTGILLAVTIIYQYFETFVKEQQELSGGIGGLF
What is the function of this protein?
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER.  It is required for assembly of membrane and secretory proteins.  Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).
What are the official names of this protein?
Protein transport protein Sec61 subunit alpha, Secretory 61 complex subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RPOA_PARPJ
Sequence: MQTSLLKPKIIAVESLGESHAKVVMEPFERGYGHTLGNALRRVLLSSMIGYAPTEVTIAGVVHEYSTLDGVQEDVVNLLLNLKGVVFKLHNRDEVTVTLRKEGEGVVTAGDIELAHDCEVINPDHVIAHLSKGGKLDVQIKVEKGRGYVPGNVRRYGEESAKIIGRIVLDASFSPVRRVSYAVESARVEQRTDLDKLVMNIETNGVISPEEAIRQSARILVDQLSVFAALEGTEATAEAPSRAPQIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTENELLKTPNLGRKSLNEIKEVLASRGLTLGMKLENWPPAGLDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: MACP_STRP2
Sequence: MGKSLLTDEMIERANRGEKISGPPLLDDNEETKILPTSSSRFGYANPKDHGFSQETLKIQVEPSIHKSRRIENTKRNVFNSKLNKILFAVIFLLILLVLAMKLL
What is the function of this protein?
Required for the in vivo function of penicillin-binding protein 2a (PBP2a), which is involved in the biosynthesis of cross-linked peptidoglycan (PG) of the cell wall.
What are the official names of this protein?
Penicillin-binding protein 2a activator MacP, PBP2a activator MacP, Membrane-anchored cofactor of PBP2a.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type IV membrane protein. Note=Localizes to sites of new peptidoglycan (PG) synthesis at midcell independently of PBP2a.
Protein: YR895_MIMIV
Sequence: MYDQDINTINVENFYNFSKQLPITPIRIVSYFLRSKFLDPKDKEEYKIRGWESRAPYVYQLLNRVGADIILLQGMNLDQCKNIISFLEPFGYNVQFRAAHSGKESREIIDDEWTGAFIGIAYSMNKFTILNKGGFWLKEDPDIPPPSIADNSENRRSVERGGTDKCFGDTHSYRYVFYETLLNIESNIPITIGTSHFPIGGINSRIKSSKLVMERLCKISDGHPLVFGGALMLFEDKDGNTAYETLTRYACDYRNSKDHYGHQTSFIGYPNDPFKVDINSNGIVSPRNLDLIFHRGLQSIRSFIMSGEFNSLEKKLVEPLIAPIKDSDKRQFASDRCLIGVDLQFNRSAKKEIFQRTLNNENSFNFSKNLSPKIIRTVNWNIRTSFLDPKDKKEYSIRGWQSRKHYVTEMLTHLAPDLILLQEMSPSQANDMKMFLNSIGYEVIFRTAHTGHDLYEIIDGEWTGALTGISYFRNRFFINCHGGFWLKDDPHTPPPLDADNAENRRPIQEGGIDKCFGDTHSYRHCQWATLLDVQSQQLITTAVSDFPIGGKDSRLKSAILCNSMLREISGENCLIFGGEICTFEDKGMDGFDTYKKITEQATDWRNTLYGHYGHQATFVGYHTDKYKVEIDNHGIVSPRNIDIIVHRGFTQGIRSFSLSGEFNPSEKKLNKPLISVVIIQKTDYFHQTIF
What are the official names of this protein?
Uncharacterized protein R895.
Protein: ARR1_YEAST
Sequence: MAKPRGRKGGRKPSLTPPKNKRAAQLRASQNAFRKRKLERLEELEKKEAQLTVTNDQIHILKKENELLHFMLRSLLTERNMPSDERNISKACCEEKPPTCNTLDGSVVLSSTYNSLEIQQCYVFFKQLLSVCVGKNCTVPSPLNSFDRSFYPIGCTNLSNDIPGYSFLNDAMSEIHTFGDFNGELDSTFLEFSGTEIKEPNNFITENTNAIETAAASMVIRQGFHPRQYYTVDAFGGDVLLSAMDIWSFMKVHPKVNTFDLEILGTELKKSATCSNFDILISLKHFIKVFSSKL
What is the function of this protein?
Transcription activator required for resistance to arsenic compounds and for a regulated expression of ACR2, ACR3 and YCF1.
What are the official names of this protein?
Arsenical-resistance protein ARR1, AP-1-like transcription factor YAP8, Arsenic compound resistance protein 1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. YAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localized in the cytoplasm under non-stress conditions and redistributed into the nucleus after HOG1 phosphorylation in the presence of arsenic (PubMed:15147884, PubMed:31772124). The major karyopherinse CRM1 mediates nuclear export which is also regulated by arsenic stress (PubMed:15147884).
Protein: SPINZ_CHICK
Sequence: MKTPFGKSPGQRSRADAGHAGVSASMMKKRTSHKKHRNNVGPSKPISQPRRNIVGCRIQHGWKEGSGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELHKDERVSALEVLPDRVASSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPIMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
What is the function of this protein?
May play a role in mitosis.
What are the official names of this protein?
Spindlin-Z, chSpin-Z.
What is the protein family that this protein belongs to?
Belongs to the SPIN/STSY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BDS3_BUNGR
Sequence: PCFCGKTVGIYWFALYSCPGGYGYTGHCGHFMGVCCYPANP
What is the function of this protein?
Potently and selectively inhibits voltage-gated potassium channels Kv11/KCNH/ERG.  Acts as a gating-modifier toxin that shifts the voltage-dependence of ERG activation in the positive direction and suppresses its current amplitudes elicited by strong depolarizing pulses that maximally activate the channels.
What are the official names of this protein?
U-AITX-Bg1a.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: ARC2_DROME
Sequence: MTQMSDEQFRIFIETIKSLGPIKEEPPSKGSFSNCTVRFSGQRDHDAVDEFINAVETYKEVEGISDKDALKGLPLLFKSIAVVWWKGVRRDAKTWSDALQLLRDHFSPTKPSYQIYMEIFETKQSYDEVIDSFICKQRALLAKLPEGRHDEETELDFIYGLMQPKYRESIPRHEVKTFRELLDRGRTVERTRH
What is the function of this protein?
Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer.  Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells.
What are the official names of this protein?
Activity-regulated cytoskeleton associated protein 2, dArc2.
What is the protein family that this protein belongs to?
Belongs to the ARC/ARG3.1 family.
What are the subcellular locations of this protein?
Extracellular vesicle membrane. Note=Forms virion-like extracellular vesicles.
Protein: PEX30_YEAST
Sequence: MSGNTTNVHETRAKFAETLQPRIGGNTTKVIRAALEKNEAESGVSEDNDNGSLEKVNVATSPLLTSTPPTISKALVKLYPYLILIDEFLNVVTWTGKNIWSSVLMLCLFITTVEYFETLVKYFGHLAIIAILWGYSLLDNYIEGTLSSSPTLEDIALLMNRVSLKSDILLSPMVNLGTQDIQRLLYTTVILSPIYVMITWLLLPPRSLMLMVGMFLLTYHSPWSKVARRLLWKFKIVRLLVFYVTGLDLGGINKDQGIFATVQKQVKKLASTENSNGVLSDSKPIRFTYVLYENQRRWLGIGWKPSMLSYERTPWTDEFLNEAPSPENFHLPEETNTMVWRWVDKTWRLDMTNDGAIQVPNSKARTSADPSPDEGFIYYDNTWKKPSKEDSFSKYTRRRRWVRTAELVKTSDFDESVINSNRNSAIEQKVEENSTNGLTAEQELGSNKQEKDNAKKVGEPTTEETKEFAEASNINEGEFERISSTDEEVLKSRARDRLAKVLDDTEEKEQSNPTIGRDSKKAV
What are the official names of this protein?
Peroxisomal membrane protein PEX30, Peroxin-30.
What is the protein family that this protein belongs to?
Belongs to the PEX28-32 family. PEX30/31 subfamily.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: LEUC2_DEIRA
Sequence: MGMTIAEKMLAAHSGHDTVVPGQLIECATDWVLCHEITTPAALRMLEERGMDRVFDPQKIVAVPDHSVPAMNIKAAKMYQKLKSWVQEKGIEHFYDVGRGGIAHVVLENTGLMKPGQTLVSGDSHTCNAGALGAFATGVGSTDLAGAIYAGKVWFKVPETMLIRVTGKTNPGVTPKDIVLEVIKQIGADGANYMVMEWVGDYIDQLDMEGRFTLTNMAIEAGGKTGIVAVDDTTRAYMQQRGVSPEQYTEYQSDPDAKYKVVVEIDAAQVEPTVAYPHIPSNGRVAGSDRIRVTHAYVGSCTNGRITDLRDVARILKGRKVAQDVQMIVVPATQAIWKQAAQEGLLEIFVDAGASVSYPSCGACLGMHSGVLGPDDICISSSNRNFVGRMGDPSAQIYLASPATVAASAVEGFIADPRRYDAEGNDLNAAD
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit 2, Alpha-IPM isomerase 2, IPMI 2, Isopropylmalate isomerase 2.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: PA2GC_MOUSE
Sequence: MKGIAIFLVFIFYWTTSTLSSFWQFQRMVKHVTGRSAFFSYYGYGCYCGLGGKGLPVDATDRCCWAHDCCYHKLKEYGCQPILNAYQFTIVNGTVTCGCTVASSCPCGQKACECDKQSVYCFKENLATYEKAFKQLFPTRPQCGRDKLQC
What is the function of this protein?
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.  Testis PA2 may be important in the production of prostaglandins, by the release of arachidonic acid, which in turn are necessary for the contractions of the seminiferous tubules and the testicular capsule; they also seem to decrease sperm transit time through the male reproductive tract.
What are the official names of this protein?
Group IIC secretory phospholipase A2, GIIC sPLA2, sPLA2-IIC, 14 kDa phospholipase A2, PLA2-8, Phosphatidylcholine 2-acylhydrolase 2C.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: IZUM1_RAT
Sequence: MGLHFTLLLAALANCLCPARLCIICDPFVVAAIKTLEQNYLPTHLAPEHHEDVMKRVEQEVRNFADLPLNQNTFLGVVDEDTLEQASWSFLKDLKRITDSDVKGELFVKELFWMLRLQKDIFATLVARFQKEVYCPNQCGTMSQTLIWCNKCEKQMHFCRKSMDCGERQIEVHRLEDMVLDCQLSWHHASEGLTDYSFYRVWGNSSETLMSKGKEPYLTKTMVGPEDAGNYRCELDTVNAGPATIIYYHVTVLPPRSVEEKPPPNIVTQEEEETPVQVIVPTLEPEPEPEPIPTVTHRPEKKLKSRLLILLILGFVVLVASVIASVLHFRKTRVKSKNSNVENKTSAAEFKSEAESPQKMGSRKLSQAEFHTDSSDKVEEADN
What is the function of this protein?
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg.  The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion.  The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
What are the official names of this protein?
Izumo sperm-egg fusion protein 1, Oocyte binding/fusion factor, OBF, Sperm-specific protein izumo.
What is the protein family that this protein belongs to?
Belongs to the Izumo family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Note=Localizes initially to the acrosome membrane of the sperm head (both outer and inner acrosomal membranes). During the acrosome reaction, translocates to the plasma membrane.
Protein: RS11_CAMJJ
Sequence: MAKRKIVKKKVVKKNIAKGIVYISATFNNTMVTVTDEMGNAIAWSSAGGLGFKGSKKSTPYAAQQAVEDALNKAKEHGIKEVGIKVQGPGSGRETAVKSVGAMEGIKVTFLKDITPLAHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: APTX_PIG
Sequence: MSNVSLSPSAVSRIMTRVCWLVRQDSRHQRIKLPHLEAVIVGRGPETKITDKKCSRQQVQLKAECNKGYVKVKQVGVNPTSIDSVIIGKDQEMKLQPGQVLHMVNELYPYVIEFEEEAKSPGLKTHRKRKRSGNSDSVERDASQEAKPSTGAEPGSNPSQCSVPPKKEKDAATKKESLSHWSQGLKISMEDPKMQVYKDDQVVVIKDKYPKARYHWLVLPWASISSLKAVTREHLELLRHMHTVGEKVIADFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWPK
What is the function of this protein?
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair.  Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species.  Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined.  Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity).  Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
What are the official names of this protein?
Aprataxin, Forkhead-associated domain histidine triad-like protein, FHA-HIT.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization (By similarity).
Protein: RS2_STAAT
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMKKYIFTERNGIYIIDLQKTVKKVDEAYNFLKQVSEDGGQVLFVGTKKQAQESVKSEAERAGQFYINQRWLGGLLTNYKTISKRIKRISEIEKMEEDGLFEVLPKKEVVELKKEYDRLIKFLGGIRDMKSMPQALFVVDPRKERNAIAEARKLNIPIVGIVDTNCDPDEIDYVIPANDDAIRAVKLLTAKMADAILEGQQGVSNEEVAAEQNIDLDEKEKSEETEATEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: AFRP_STRGR
Sequence: MAKQARAVQTWRSIVDAAASVFDDYGYERAAISEILRRAKVTKGALYFHFASKEAIAQAIMDEQTSTVEFEQEGSPLQSLVDGGQQFAFALRHNSMARAGTRLSIEGVFLGGPHPWGDWIDATARMLELGQERGEVFPQIDPMVSAKIIVASFTGIQLVSEADSGRADLRGQVAEMWRHILPSIAHPGVIAHIKPEGRVDLAAQAREKAEREEQEARIAAEAKGAGSDAATDSGSRSGGSGLRGGGSGRGPRAGGAGDEGDEEPAGAGVAAGGVVA
What is the function of this protein?
Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation.
What are the official names of this protein?
A-factor receptor protein, A-factor-binding protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24E_PICTO
Sequence: MDVRNCSFCGKSIEPASGFLYVRKDGSVLNFCSRKCKENMVKLKRVPRKVKWTNEYHRIKAMTKKA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: UREE_NOSP7
Sequence: MLTFTQLKPPNGDATVTFTLALTAEERTRSRHRFETEDGKVVFLHLPRGTVLHDGDILLEETHNSLIRIIAKPELVVTAFAQTPLLLLRAAYHLGNRHVPVEITPTYLRFSSDSVLRAMLEQLGLEVKEEILPFQPELGAYGQHHHAH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_LEUCK
Sequence: MSGVIVVGSQWGDEGKGKIVDFFAEHADAVVRYQGGNNAGHTIWHGNTKFELSALPSGILTEGQLAVIGNGVVVNPEALLAEIAEVQSQGIAIDNLRISNRAHVIMPYHIALDKAAESSTNNRIGTTKKGIGPAYTDKISRVGIRVADLVDPDVFAKLLKEYLPFKNAQLTKLYNEEALNYDDIYETYVEYGRQLAPYVTDTSYLLGQMIANKKRVVFEGAQGIMLDVDHGTYPYVTSSNPTAGGVMNGAGVGPKQIQDVVGVIKAYTSRVGEGPFPTELHDDIADHIREVGHEYGVVTKRPRRIGWLDAVALRHAVQVSGLTKLAINSLDVLTGLKTLKIATSYTYKGEEIHHFPASDTWFEGLDVNFETLPGWDEDITGVQSFDELPANAQNYLKRISDLLSVDLLSFAVGPKPEETHLLSDVWQ
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.