PharMolix/UniProtQA huggingface dataset:
Protein: ATPG_BORPA
Sequence: MPGIKEIRTKIKSVQNTRKITKAMEMVAASKMRKAQERMRAGRPYATKVREIAAHLMQANPEYGHPYLVEREVKAVGVVLVTTDKGLCGGLNTNISRVTLSKLKEFEQRSIKVQATAFGNKGLGLLTRIGAKLVSQEVQLGDKPDLDRLLGAIKVQLDDYLEGRIDALYVATTRFVNTMRQEPVFLRLLPLSNGLDDPFQSGVETLAKTAEIKSDYSWDYIYEPDAKSVIDDLLQRYVEGLLYQAVAENMASEQSARMVAMKSASDNAKKVIGDLQLVYNKTRQAAITKEISEIVGGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EX7S_STRZP
Sequence: MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKELQATLDKAEKTLVKVMQEDGTESDFE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_PROM2
Sequence: MAIISSNIDDNDFSLRKKELRLVDSKVIPEEKKNNNLNLARPLNFKEFIGQEQLKSSLRIAIDASIFRKEPLEHTLLYGQPGLGKTTLAFLIAHELKTKCRIATAPAIERPRDIVGLLLGLKEGEVLFIDEIHRLNRLTEELLYSAMEDFRLDLTMGANRGARCRTINLPRFTLIGATTKLASISAPLRDRFGISQKIEFYTYDELKQIIVNFSRLINLNLDDEASYDLAKISRGTPRIALRLLRRVRDYAQVVMKTNNISVNLIKKALNSYQIDEKGLDSLDRNYLFFLNQNKNIPIGLDSIAAGLGDDSSMLEFVVEPYLIKIGFLTRTPRGRLLTALGKKYIDSKNENF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: LSHR_PIG
Sequence: MRRRSLALRLLLALLLLPPPLPQTLLGAPCPEPCSCRPDGALRCPGPRAGLSRLSLTYLPIKVIPSQAFRGLNEVVKIEISQSDSLEKIEANAFDNLLNLSEILIQNTKNLVYIEPGAFTNLPRLKYLSICNTGIRKLPDVTKIFSSEFNFILEICDNLHITTVPANAFQGMNNESITLKLYGNGFEEIQSHAFNGTTLISLELKENAHLKKMHNDAFRGARGPSILDISSTKLQALPSYGLESIQTLIATSSYSLKKLPSREKFTNLLDATLTYPSHCCAFRNLPTKEQNFSFSIFKNFSKQCESTARRPNNETLYSAIFAESELSDWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNVTVLFVLLTSHYKLTVPRFLMCNLSFADFCMGLYLLLIASVDAQTKGQYYNHAIDWQTGNGCSVAGFFTVFASELSVYTLTVITLERWHTITYAIQLDQKLRLRHAIPIMLGGWLFSTLIAMLPLVGVSSYMKVSICLPMDVETTLSQVYILTILILNVVAFIIICACYIKIYFAVQNPELMATNKDTKIAKKMAVLIFTDFTCMAPISFFAISAALKVPLITVTNSKVLLVLFYPVNSCANPFLYAIFTKAFRRDFFLLLSKSGCCKHQAELYRRKDFSAYCKNGFTGSNKPSRSTLKLTTLQCQYSTVMDKTCYKDC
What is the function of this protein?
Receptor for lutropin-choriogonadotropic hormone.  The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
What are the official names of this protein?
Lutropin-choriogonadotropic hormone receptor, LH/CG-R, Luteinizing hormone receptor, LSH-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUP85_XENTR
Sequence: MEELDVDPAETPIPGLGQQNRHIGFSWGPGDLLLYETLYQKQGSETAARCPFMYLVRSDEDIYSPVLRKLFNESHSIFVGLQKSAEENAGKSRKAQLVQVSRNYRSVLRACMEEMHALSESTREPSQNTKYISQISILSAMELSWNLCEILFIESAPAGPLLILLLDWVRLHVCEVDNIVQDVLRSERPTEHEKFWDGVTGYVLQGRMNEARQLLAKEASSSVSARSMCRVLDDLLKKMPMLNTAGTQTLTEFELKWQHWREECERHLQNGTFSSNPHMEVVCRVLVGDEEVILEKRDLMTTWYHFLVSRLLFKHPTVKPTELHFYAQSSLDMFLAGNSSPEPLDNILLAAFEFDIHQVIKEFSIVSSNWWFVAHLTDLLDHCQLFQAHNLYFGANMREFLLLDYASGLFSHHSLWQLGVDYFDYCPNLGHVYLELHMERVPLNTEKKALKALRICEKRQMTEQVRSICKTMAMQSLCNGRLGSALSWSIRAKDAAFATLISDRFLKEYSERGNFTDLDLIDNLGSAMLLSDRLTFLGKYREFHRMYSQEQFSEAASLLLSLMTARIAPCSFWLTLLLDALPLLEQKQVIFSAEQTYELMRCLEDRMAAKLDSTSPDEIQKQDSVDSTKIEMLRLALARNLARAIVTEGALQE
What is the function of this protein?
Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity).  Involved in nephrogenesis (PubMed:30179222).
What are the official names of this protein?
Nuclear pore complex protein Nup85, 85 kDa nucleoporin, Nucleoporin Nup85.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin Nup85 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Nucleus membrane.
Protein: NUSB_ECO55
Sequence: MKPAARRRARECAVQALYSWQLSQNDIADVEYQFLAEQDVKDVDVLYFRELLAGVATNTAYLDGLMKPYLSRLLEELGQVEKAVLRIALYELSKRSDVPYKVAINEAIELAKSFGAEDSHKFVNGVLDKAAPVIRPNKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: SSUD_BACLD
Sequence: MDILWFIPTHGDGRYLGTNTGGRAADHTYFQQVAQAADRLGYTGVLLPTGRSCEDPWITAAALASVTKNLKFLVAVRPGLMQPSVAARMASTFDRLAEGRLLINVVAGGDPYELAGDGLFISHDERYEATNEFLDIWRSLLKGETVSYSGKHLKTENGRLLFPPAQQPHPPIYFGGSSKAGQETAAKHADVYLTWGEPPHLVKEKIQSVKKKAEKEGRTVRFGIRLHVIVRETEKEAWQAADRLISRLEDETIAAAQNAMKRMDSSGQKRMVQLHQGNRSNLEISPNLWAGIGLVRGGAGTALVGDPETVASRIKEYADIGIESFIFSGYPHLEEAYHFAEKVFPLLPFRTKLQSKASGEVIGNDHFPSRQKEKTV
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: LEXA_BRUA2
Sequence: MLTRKQHELLLFIHERLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNRARALEVLRLPDSIAPGLSPQKKFAPSVIEGSLGKVASVQPVRPAPAPQNSEAPATVSVPVMGRIAAGVPISAIQNQTHMLSLPPEMIGAGEHYALEVKGDSMIDAGIFDGDTVIIKRGDTANPGEIVVALVDEEEATLKRFRREGASIALEAANPAYETRIFGPDRVHVQGKLVGLIRRY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: Y6457_DICDI
Sequence: METIIRRFSPKEKEKEKEKEEKDEKSKDKKEPIKTRSKSKNDEEEEEDEQELVQGKPKGNSKNIKTKK
What are the official names of this protein?
Putative uncharacterized protein DDB_G0267218.
Protein: RT12_ACACA
Sequence: MPTYHQILKNPRRKKMHTNNVKALEGCPQKKGVCVKLRIVKPKKPNSAQRKVAKLRLSTRRMIIAYIPGQGHNLQEYSSVLVSGGRAPDLPGVRYTLIKGKYDFSWKESFERKKKLSKYGYSTKKKF
What are the official names of this protein?
Ribosomal protein S12, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y286_MYCPN
Sequence: MLDYIPWIGNGHRYGNDHRGSNSSTSGVTTQGQQSQNASGTEPASTFSNVGVGLKANVQGTLGGSQTTTTGKDIPKWPTLDQANLQLWTGAGWRNDKASSGQSDENHTKFTSATGSGQQGSSSGTTNSAGNPDSLKQDKVDKSGDSVTVAETTSGDNLTNYTNLPPNLTPTADWPNALSFTNKNNAQRAQLFLRALLGSIPVLVNKSGQDDSNKFQATDQKWSYTELKSDQTKLNLPAYGEVNGLLNPALVEVYGLSSTQGSSTGAGGAGGNTGGDTNTQTYARPGIGFKLPSTDSESSKATLITPGLAWTAQDVGNLVVSGTSLSFQLGGWLVTFTDFIKPRSGYLGLQLTGLDANDSDQRELIWAPPALNRLSWQLGQPLGPRGECVGFQGGVGGSSSVRLASSYKYHHRNEGYLIGAHQCFGLSGELYRPGFVQGFHSKLRPKPKHLPLPALGAGEKSRFLW
What are the official names of this protein?
Putative adhesin P1-like protein MPN_286.
What is the protein family that this protein belongs to?
Belongs to the adhesin P1 family.
Protein: SOX2_XENTR
Sequence: MYNMMETDLKPPAPQQASGGNSNSGSNNQSKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGANPMTSGVGASLGAGVNQRMDTYAHMNGWTNGGYGMMQEQLGYPQHPGLSAHNAPQMQPMHRYDVSALQYNSMSSSQTYMNGSPTYSMSYSQQGAPGMSLGSMGSVVKSESSSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAQSRLHMSQHYQSASVAGTAINGTLPLSHM
What is the function of this protein?
Transcriptional activator.  Functions as a switch in neuronal development, participating in the differentiation of embryonic neuroectodermal cells into neural tissues by making the ectodermal cells responsive to FGF-neuralizing signals (By similarity).  Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
What are the official names of this protein?
Transcription factor Sox-2, SRY (sex determining region Y)-box 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: CBIM2_PELPD
Sequence: MHIMEGFLPVEHAIGWSVASAPVVAYGLYSINKKIKKNPEQRMLLGVAAAFTFVLSALKMPSVTGSCSHPTGTGLGAILFGPSAVAPIGAVVLLFQALLLAHGGLTTLGANIFSMAIVGPFAAAAVFRLARAARFPFGVGVFLAASLGDLLTYVTTACQLAFAFPDPVGGFTASLAKFAGVFALTQIPLAISEGLLTVVVMNALLRFNREELGSLNIEGNGQEVQA
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
What are the official names of this protein?
Cobalt transport protein CbiM 2, Energy-coupling factor transporter probable substrate-capture protein CbiM 2, ECF transporter S component CbiM 2.
What is the protein family that this protein belongs to?
Belongs to the CbiM family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVA_LACJO
Sequence: MFEYLKGIVTKIDPAYIVLDVNGVGYKILCPTPYSYDENQPATIYVEQVVRDTGITLYGFLSLEDKELFLKLLSVSGIGPKSAVAIMAAEDTDSLASAIQNGEVKYLTRFPGVGKKTASQIVLDLKGKLGDYVKKSTAAADLTPSLQDALLALVALGYTQKEVDRITPKLAKLPENTADGYVKEALALLLKK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: Y538_PROM3
Sequence: MAGHSKWSQIKRSKAVVDAKRGAVFTRLAREISVAARSGGDPNGNFQLRTAINKAKAARMPAANIERAIAKGSGHDQHGACQLEAIRYEGYGPGGVAVLIEALTDNRNRTAADLRLTFNKHGGKLGESGCVAYLFEQRSEVYLSAQSAQDGGKVSEDALLENLLELEADGYQLIDDGGAVVYGPFQALEGLQAGLRDQGWIIEGWEHCWRPLTTISQADQKSEDQCLQLLDALDELDDVHHISSNLES
What are the official names of this protein?
Probable transcriptional regulatory protein P9303_05381.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACYP_BORBR
Sequence: MSDAHMETVHVIVKGKVQGVGYRHAAVRRAHMLGVTGWVQNLPDGTVEAVVQGTADQVDHMLEWLRRGPPAAQVRELASERSFEEKRYKHFAQL
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: TDH_ECO5E
Sequence: MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMSGAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDDFQKGFDAMCSGQSGKVILSWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD1B1_SHEEP
Sequence: MLLLPLLLLAVIVPGGDNEDVFQGPTSFHVIQISTFANSTWAQNQGSGWLDNLQLYGWDSDPGTTIFLKPWSKGNFSDEEVTELEELFRVYLIGFTLEVQDHVSEFQLEYPFVIQDIAGCELHPGKAVESFLKGAFGGLDFVSIKNDSCAPVPEGGSMAQRFYELIIQYHAICDTIAKLLLETCPRYFLSVLDAGKAELQRQVKPEAWLSSGPTPGPGRLLLVCHVSGFYPKPVWVMWMRGEQEEPGTQQGDIMPNANWTWHLRATLDVAAGEAAGLSCRVKHSSLGDQDIVLYWGHPTSTGLIFVAIIVSSLILLICLALWFWRRWSYLTIL
What is the function of this protein?
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
What are the official names of this protein?
T-cell surface glycoprotein CD1b-1, sCD1A-25.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. Localizes to cell surface lipid rafts (By similarity).
Protein: KAD_METTP
Sequence: MNIVLLGPPGSGKGTQAKMIAEKFNVKHISTGDILREHVRNGTELGKEAKKYMDAGQLVPDSILIGIIKDRLSKPDVAGGYMLDGYPRTIPQAEALDKILPELKQKIDVVLNIDVPDEELVRRLSGRRMCKCGRSYHIIFNPPKVPGKCDECGGELYHRDDDKEEAILNRLKVYKQQTQPLIDYYTKAGLIANINGAGEINQIFDEISKVLSKFQ
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_GLOVI
Sequence: MDPVRVAIQRLAHCFALPTCAHPGDAGLDLFAAHAVPLSIAPGRFTRVPTGIALGLPAGYMAFVQPRSGLAARHGISVLNTPGLIDCGYRGEIQVLLINHGEVPVVVSRGDRIAQLVVLPVPQVQFVEVSTLESSERQTGSFGSSGY
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: BDNF_RAT
Sequence: MTILFLTMVISYFGCMKAAPMKEANVHGQGNLAYPAVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIEELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
What is the function of this protein?
Important signaling molecule that activates signaling cascades downstream of NTRK2.  Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2.  Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD).  Binding to NGFR and SORCS2 promotes neuronal apoptosis.  Promotes neuronal growth cone collapse.
What are the official names of this protein?
Brain-derived neurotrophic factor, BDNF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted. SUBCELLULAR LOCATION: [BDNF precursor form]: Secreted. Note=A proportion of BDNF is secreted as immature precursor (proBDNF).
Protein: DEP6_ALTBR
Sequence: MRSSSAGTPFTAQYACEICRERKVRCDRALPKCRRCDRLNQPCSYNQAHQRRTRDEQLKQLQERLAKTEAQLAMNTTAAPLSVRSQSRSEGTELASSTRWIGTPDSFTPNSCSRRSSQYQLPTTSTSQSQLGSVLGTTAANTPMDLDNIRGMSATSGMSTNGSSLFDSDLFTSFTEGADSNMTFAWTNQPLMALEPLDNMLLNRPQSAPPNGSEEDLSPTDLSLLHNHYFESVYFSFPFINRDRFTAEKTGSRSPATTALVYAVALAGCTRSLQDHNRQSTCYGLARNYAERCEQEDHLNDLNFLQALLLIGRFEAMNRKLERSGLTLGRAAMLCKLLKLHQMDKSEHSQGMQNRETQSGPRLALPHTKDPVLLEERRRTFWGLYILQSYVRTRTGWEFQLEDTKNLQINLPSPGLLRSDLEPLKMPSLLNISTEPAPEITSYAGCVLMVELALRCFDNGQKRDTPGFWDDYCALVKKTDDLFKTLKRHLNATSIREDPVAFSLYLNLRATEIFSHDSAITKNEEQGLPPLMVAESQRRATTAAFQICSAVGLNLPSPWKADSDIIMLQAIFIAWPLTMALKALYRELVRGGIRETVNGVVASIRLLFAALDHIEESDGHWHQCVTNVEAKLQEWDEKNSFDSLAL
What is the function of this protein?
Transcription factor that positively regulates the expression of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099).
What are the official names of this protein?
Depudecin biosynthesis cluster-specific transcription activator DEP6, Depudecin biosynthesis cluster protein 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: COAX_PSEMY
Sequence: MILELDCGNSFIKWRVISPGGRERICAGIVDSDDGLFEALAGSGVKVQRCRLVSVRSDAETEQLVTRLKASLGVEVVCAQSSSQVGGVRNGYHDYQRLGLDRWLALLGGYHLGQRACLVVDLGTAVTADFVSADGEHLGGFICPGLPLMRDQLSTHTRRIRYDREVALAALQELEPGRSTAEAVERGCLLMLRGFVAEQLAQARSRFPGGFEVFLTGGDAELVRDAVPEAQVVPDLVFVGLAIACPLS
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURQ_BACCQ
Sequence: MLENLSTEHRNEKTMNLDEMSIKEVLQSMNEEDRTVALAVENEIEQIEKVVQTVIKSFEEEGRLIYIGAGTSGRLGILDAVECPPTFGTDDKMVQGFIAGGLKAFTKAVEGAEDREELAEEDLKSIGLNEKDTVIGIAASGRTPYVIGGLKYANSVGASTASISCNKNAEISKYAKLNVEVETGAEILTGSTRLKAGTAQKLVLNMISTASMIGVGKVYKNLMVDVQSTNEKLIERSKRIIVEATGVSYEVAAEHYEKAERNVKAAIVMVLLQCEYGEALEKLKEAKGFVKKAL
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: COPZ_STAES
Sequence: MTQKIIKVEGMSCEHCRNAVESALAKLNGVSSAEVNLDENHVRVEYNDSKVTFENMKEAIEEQGYDVK
What is the function of this protein?
Chaperone that serves for the intracellular sequestration and transport of Cu(+).  Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA) (By similarity).
What are the official names of this protein?
Copper chaperone CopZ.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURE_GEOTN
Sequence: MKLQTLLSRLPGFWVHRGGNPDIVALEMDSRHVTPGSLFFCVKGFTVDGHDFAEQAVERGAVAIVAERPLSVNVPVVVVPDSRRAMAILADAFYGQPTHRLHLIGVTGTNGKTTTTHIIEQVARKAGKKIGLIGTVGTKIGDRSYPAVNTTPESLVLQRTFKQMVDEGVEFVTMEVSSHALHQGRVHGCDYDVAVFTNLTQDHLDYHGTMEEYRNAKGLLFAQLGNRYDERRPKFAVLNHDDPVSQYYKHMTAAPIITYGIKEKSDVMAEQIEMTPGGMAFQLCTPHGTMAIETKLVGLFNVYNLLAATAACLASGFSLATIAEALANVSPVPGRFETVDEGQNFTVIVDYAHTPDSVENALKTVRQFAKRNVYVVIGCGGDRDRTKRPLMAQAAVRYADVAVFTSDNPRSEDPRQILRDMEAGVSAGDGTYVTIPDREEAIRYAIGQAQEGDVVLIAGKGHETYQIIGDDVIDFDDRAVARAAVKERR
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_NOSP7
Sequence: MAINTDTSGKQKALTMVLNQIERSFGKGAIMRLGDATRMRVETISSGALTLDLALGGGLPKGRVIEIYGPESSGKTTVALHALAEVQRNGGIAAFVDAEHALDPTYAAALGVDIDNLLISQPDTGESALEIVDQLVRSAAVDIVVIDSVAALVPRAEIEGDMGDAHVGLQARLMSQALRKITGNIGKSGCTVIFINQLRQKIGVTYGSPETTTGGNALKFYASVRLDIRRIQTLKKGTDEYGNRVKVKVAKNKVAPPFRIAEFDIIFGKGISTLGCVVDLAEETGIIIRKGAWYSYNGDNISQGRDNAIKYLEEKPEFAEEIKKLVREKLDKGAVVSANSVAKASEEDEEEEVDLEPEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEN2_MOUSE
Sequence: MAEAVFRAPKRKRRVYESYESPLPIPFGQDQGPRKEFRIFQAEMISNNVVVRGTEDMEQLYGKGYFGKGILSRSRPNFTIANPTLAARWKGVQTDMPIITSEKYQHRVEWARDFLRRQGHDESTVQKILTDYTEPLELPCREEKEETPQHEPLSSKADSSLEGRVEKDELPVTPGGAGQSDDLPGLGTHSDCLQEGPGHATLAAASPSSHNGHVAEDPEVLPQETLVPQGGLWPEASSQAAGEKRAAHEYVLIEEELCGAQEEEAAAASDEKLLKRKKLVCRRNPYRIFEYLQLSLEEAFFLAYALGCLSIYYEKEPLTIVKLWQAFTAVQPTFRTTYMAYHYFRSKGWVPKVGLKYGTDLLLYRKGPPFYHASYSVIIELLDDNYEGSLRRPFSWKSLAALSRVSGNVSKELMLCYLIKPSTMTAEDMETPECMKRIQVQEVILSRWVSSRERSDQDEL
What is the function of this protein?
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA.  It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini.  There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.  Probably carries the active site for 5'-splice site cleavage.  The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity).
What are the official names of this protein?
tRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2.
What is the protein family that this protein belongs to?
Belongs to the tRNA-intron endonuclease family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.