PharMolix/UniProtQA huggingface dataset:
Protein: MNMA_MESM1
Sequence: MSKIVVALSGGVDSSVTAFILKYQQNHEVIAVFMRNWDSFANNDILGNEDINQDICPQEKDWEDAKKIASQLNIPIYRVDFVKEYYDEVFTYLIEEYRQGRTPNPDIFCNKYIKFGKFIEYVEKNFNPDFIATGHYAKVENSLLYRAKDRNKDQSYFLSQLSSDQLKKIIFPLKDLTKDVIRKIAAENNLVTAQKKDSTGICFIGERNFDKFLQNYIPNMPGNIVDIETNEVVGQHVGVMYYTLGQRKINLSGMKYPYYVAGHDLKNKILYVASIHSKNYLKSDKLEAIEFNLINKNFNKKNLTAKFRYRQEDIKIEILNIDKNKIEISYPDEFEAVTPGQHVVIYDGESCVGGGIINKTYYKGNLNQFH
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
Protein: METK_XANOM
Sequence: MSSYLFTSESVSEGHPDKIADQISDAVLDAILAQDKRARVACETMVKTGVAIVAGEVTTSAWIDLEALTRKVILDIGYNSSDVGFDGETCGVLNLIGKQSPDINQGVDRKNPEQQGAGDQGLMFGYATNETDSFMPAAIHLSHRLVEQQAKIRKKKNSALSWLRPDAKSQVTLRYEDGVATAIDAVVLSTQHDPGVKQKDLIEAVREEILKPVLPAKWLHKGTKFHINPTGKFVIGGPVGDCGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLADRCEVQVSYAIGVAEPTSISVTTFGTGKIADEQIEKLIRKHFDLRPFGIIQMLDLIHPMYQQTASYGHFGRKPKDFTYTDGTGAQHSATSFSWEKTDRADALRAAAKLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URK_STAAC
Sequence: MKATTIIGIAGGSGSGKTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTKKYADIIIPEGGSNKVAIDIMTTKIQSLVSKQ
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HAC1_HYPJE
Sequence: MAFQQSSPLVKFEASPAESFLSAPGDNFTSLFADSTPSTLNPRDMMTPDSVADIDSRLSVIPESQDAEDDESHSTSATAPSTSEKKPVKKRKSWGQVLPEPKTNLPPRKRAKTEDEKEQRRVERVLRNRRAAQSSRERKRLEVEALEKRNKELETLLINVQKTNLILVEELNRFRRSSGVVTRSSSPLDSLQDSITLSQQLFGSRDGQTMSNPEQSLMDQIMRSAANPTVNPASLSPSLPPISDKEFQTKEEDEEQADEDEEMEQTWHETKEAAAAKEKNSKQSRVSTDSTQRPAVSIGGDAAVPVFSDDAGANCLGLDPVHQDDGPFSIGHSFGLSAALDADRYLLESQLLASPNASTVDDDYLAGDSAACFTNPLPSDYDFDINDFLTDDANHAAYDIVAASNYAAADRELDLEIHDPENQIPSRHSIQQPQSGASSHGCDDGGIAVGV
What is the function of this protein?
Transcriptional activator involved in the unfolded protein response (UPR) pathway.  Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes.  Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway (By similarity).
What are the official names of this protein?
Transcriptional activator hac1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DCTA_YERPG
Sequence: MKVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAIALLYFEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALYAEQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLFGFALHRLGEKGQLIFNVIESFSRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGTIAKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWCKQLDNDQLQAVLSNKVLPNVKSSVSVS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYM_ESCF3
Sequence: MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMKQVEALVEASKEEVKATTAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16A2_CUPTR
Sequence: MPEVQRMTLTQFLIEQRRRYPDASGGFNGLILNVAMACKEIARAVAFGALGGLHGRAGGPDAAGAAINVQGEVQQKLDVLSNDTFLRVNEWGGYLAGMASEEMEAPYQIPAHYPRGKYLLVFDPLDGSSNIDVNVSVGSIFSVLRAPEGTADVTEQAFLQPGTAQVAAGYALYGPTTMLVLTVGNGVNGFTLDPNLGEFFLTHPDLRVPADTREFAINASNSRFWEAPIRQYVSECLAGQTGPRGKDFNMRWIASMVAEAHRILMRGGVFMYPRDTKDPARPGRLRLLYEANPIAFLMEQAGGRASTGRQALMSVAPNALHQRIGVIFGSRHEVERIERYHNEQTDPDLPNPLFNERSLFRASA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1 2, FBPase class 1 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_LEPIC
Sequence: MRSHNDFESITIRLASPERIKEWSYGEVKKPETINYRTLKPEKDGLFCEKIFGTTKDWECYCGKFKSIRYKGVVCDKCGVEVTHSKVRRERMGHIELAAPVSHIWYYRSVPSRMGLLLDMTVNQLKSVLYFEKYVIIDPADSGRNRGELIDEEEYHGYLDEYGDKFVAGIGADAIKELLARIDVDAEARMIRQKIQDKDKISDKRILKRLEVLEAFRDSGNRPEWMVLDIVPVIPPELRPMVQLEGGRFATSDLNDLYRRVINRNNRLKRLLALKAPEIIVRNEKRMLQEAVDALFDNSRRKRAVKGKGNRPLKSISDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKYHEMGLPKKMALELFKPFIMKRLVDLDLAPNIKSAKKKVEAEDKEVFDVLEYVVKEHPVMLNRAPTLHRLGIQAFLPVLVEGKAIKLHPLVCHAFNADFDGDQMAIHVPLTPKAQLETWMLMLSPHNILNPANGHPICGPTQDIVLGIYYLTSELPSEPGVPLKSFSNLEEVHYAIDRGVVEFRTKISVYHQGKILETTPGRLIFNTILPEGYAYVNRPLSDKETNRIIADVYDKYGPAKTVLMLDDIKKLGYRYATLFAPTISIEDIRVSPGKVGLVGDANKEVEKADSEYRKGIITNEERRKKVIEIWTKTNDLITESMFKELEKDKGGFNPVFIMAASGARGSKQQIRQLAGMRGLMAKPSGEIIELAIRSNFREGLSVLEFFISTHGARKGLADTALKTADAGYLTRRLVDISQDVIISEDDCGTEESISLGVVKEGENVIVSLNDRVFGRYTAEDVIDPVTDQVVYPRNTLITREVGQKVENLGYDKIRVRSPLTCESKQGVCIRCYGMDMARLIPAEIGEAVGTIAAQSIGQPGTQLTMRTFHIGGAASAKVQEKEHKVSYTGIVNNINGRLITNEKSQSVFSRRGSIVIQRLIQQYKTEELSNLRVENGQKVDKGELVATSPAGENITSEMPGTIHIENGLFRILGEEAVIPVKTGTIVNVKVNDITQPNQPLAEFDPYNEVGISEIDGTVQWMDLEIGKNVRRDEDLRTSNILLKVIEQRREKLNPRIAVISGGSREEYSVPVDAIISVQDGDKVKAGDILFKIPTVAEKTRDITGGLPRVDELFEARRPKDATTLAETDGKIEISGEIVKEKRVLYIHPDNPDLEKVKVTIPIGKQIRVRNGDFVKRGDQIDDGNLDPHDILRVKGVTALQVYLVQEVQEVYRLQGVHINDKHIEVVVRQMLRKVLITDSGDTSFVNQQQIDRLVFNEENKRVIAEGGSPAESVPILLGLTKASLNTESFFSAASFQETTKVLTDAAIKGKTDNLMGLKENVIIGHMIPAGTGTKKYKDIAVFKSAYGDLDRPLEEEEEEEIPQAIAEESDAEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RL30_YEAST
Sequence: MAPVKSQESINQKLALVIKSGKYTLGYKSTVKSLRQGKSKLIIIAANTPVLRKSELEYYAMLSKTKVYYFQGGNNELGTAVGKLFRVGVVSILEAGDSDILTTLA
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L30, L32, Large ribosomal subunit protein eL30, RP73, YL38.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_PSEU2
Sequence: MARIAGVNIPDNKHTVISLTYIYGVGRTTAQKICATTGVNPAVKIKDLSDEQIEQLRGEVAKFTTEGDLRREINMKIKRLMDLGCYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: BLN04_BRELC
Sequence: MATMRRICFLFVFNLAVATSTQGISDEISPDIPETSQAVIDGHRLKGSSKVSKATTGSEERFIRSQLQFLINKIFGARGVAKVLVEEGPKSGVFNKLKEILVKISKFEMKGDMLYMVYIYTILFLSIPIILGVAMYINHHVESSYIH
What is the function of this protein?
Secreted effector that inhibits stress-induced relocalization of the transcription factor NAC069 to the nucleus, thus affecting its broad role in abiotic and biotic stress responses.
What are the official names of this protein?
Secreted RxLR effector protein BLN04.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host membrane; Single-pass type I membrane protein.
Protein: VL1_HPV2A
Sequence: MSCGLNDVNVSTISLQMALWRPNESKVYLPPTPVSKVISTDVYVTRTNVYYHGGSSRLLTVGHPYYSIKKSNNKVAVPKVSGYQYRVFHVKLPDPNKFGLPDADLYDPDTQRLLWACVGVEVGRGQPLGVGVSGHPYYNRLDDTENAHTPDTADDGRENISMDYKQTQLFILGCKPPIGEHWSKGTTCNGSSAAGDCPPLQFTNTTIEDGDMVETGFGALDFATLQSNKSDVPLDICTNTCKYPDYLKMAAEPYGDSMFFSLRREQMFTRHFFNLGGKMGDTIPDELYIKSTSVPTPGSHVYTSTPSGSMVSSEQQLFNKPYWLRRAQGHNNGMCWGNRVFLTVVDTTRSTNVSLCATEASDTNYKATNFKEYLRHMEEYDLQFIFQLCKITLTPEIMAYIHNMDPQLLEDWNFGVPPPPSASLQDTYRYLQSQAITCQKPTPPKTPTDPYASLTFWDVDLSESFSMDLDQFPLGRKFLLQRGAMPTVSRKRAAVSGTTPPTSKRKRVRR
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: NUOC_BRUSI
Sequence: MSEEALGELSGYIRERLGDAIEEANLAYGELTLCVPVASLIGVLTFLRDDVQCQFVNLTDISGVDYPQREKRFDVVYQLLSPRQNQRIRVKVQADEDTLVPSAVPVFFGAEWYEREAYDMYGILFSGHPDLRRILTDYGFEGHPLRKDFPLTGFVEVRYNDELKRVVYEPVQLRQEFRNFDFLSPWEGTDYVLPGDEKAKTN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: COIA1_MOUSE
Sequence: MAPDPSRRLCLLLLLLLSCRLVPASADGNSLSPLNPLVWLWPPKTSDSLEGPVSKPQNSSPVQSTENPTTHVVPQDGLTEQQTTPASSELPPEEEEEEDQKAGQGGSPATPAVPIPLVAPAASPDMKEENVAGVGAKILNVAQGIRSFVQLWDEDSTIGHSAGTEVPDSSIPTVLPSPAELSSAPQGSKTTLWLSSAIPSSPDAQTTEAGTLAVPTQLPPFQSNLQAPLGRPSAPPDFPGRAFLSSSTDQGSSWGNQEPPRQPQHLEGKGFLPMTARSSQQHRHSDVHSDIHGHVPLLPLVTGPLVTASLSVHGLLSVPSSDPSGQLSQVAALPGFPGTWVSHVAPSSGTGLSNDSALAGNGSLTSTSRCLPLPPTLTLCSRLGIGHFWLPNHLHHTDSVEVEATVQAWGRFLHTNCHPFLAWFFCLLLAPSCGPGPPPPLPPCRQFCEALEDECWNYLAGDRLPVVCASLPSQEDGYCVFIGPAAENVAEEVGLLQLLGDPLPEKISQIDDPHVGPAYIFGPDSNSGQVAQYHFPKLFFRDFSLLFHVRPATEAAGVLFAITDAAQVVVSLGVKLSEVRDGQQNISLLYTEPGASQTQTGASFRLPAFVGQWTHFALSVDGGSVALYVDCEEFQRVPFARASQGLELERGAGLFVGQAGTADPDKFQGMISELKVRKTPRVSPVHCLDEEDDDEDRASGDFGSGFEESSKSHKEDTSLLPGLPQPPPVTSPPLAGGSTTEDPRTEETEEDAAVDSIGAETLPGTGSSGAWDEAIQNPGRGLIKGGMKGQKGEPGAQGPPGPAGPQGPAGPVVQSPNSQPVPGAQGPPGPQGPPGKDGTPGRDGEPGDPGEDGRPGDTGPQGFPGTPGDVGPKGEKGDPGIGPRGPPGPPGPPGPSFRQDKLTFIDMEGSGFSGDIESLRGPRGFPGPPGPPGVPGLPGEPGRFGINGSYAPGPAGLPGVPGKEGPPGFPGPPGPPGPPGKEGPPGVAGQKGSVGDVGIPGPKGSKGDLGPIGMPGKSGLAGSPGPVGPPGPPGPPGPPGPGFAAGFDDMEGSGIPLWTTARSSDGLQGPPGSPGLKGDPGVAGLPGAKGEVGADGAQGIPGPPGREGAAGSPGPKGEKGMPGEKGNPGKDGVGRPGLPGPPGPPGPVIYVSSEDKAIVSTPGPEGKPGYAGFPGPAGPKGDLGSKGEQGLPGPKGEKGEPGTIFSPDGRALGHPQKGAKGEPGFRGPPGPYGRPGHKGEIGFPGRPGRPGTNGLKGEKGEPGDASLGFSMRGLPGPPGPPGPPGPPGMPIYDSNAFVESGRPGLPGQQGVQGPSGPKGDKGEVGPPGPPGQFPIDLFHLEAEMKGDKGDRGDAGQKGERGEPGAPGGGFFSSSVPGPPGPPGYPGIPGPKGESIRGPPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPHRQTVSVPGPPGPPGPPGPPGAMGASAGQVRIWATYQTMLDKIREVPEGWLIFVAEREELYVRVRNGFRKVLLEARTALPRGTGNEVAALQPPLVQLHEGSPYTRREYSYSTARPWRADDILANPPRLPDRQPYPGVPHHHSSYVHLPPARPTLSLAHTHQDFQPVLHLVALNTPLSGGMRGIRGADFQCFQQARAVGLSGTFRAFLSSRLQDLYSIVRRADRGSVPIVNLKDEVLSPSWDSLFSGSQGQLQPGARIFSFDGRDVLRHPAWPQKSVWHGSDPSGRRLMESYCETWRTETTGATGQASSLLSGRLLEQKAASCHNSYIVLCIENSFMTSFSK
What is the function of this protein?
Potently inhibits endothelial cell proliferation and angiogenesis.  May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (PubMed:9008168).  Inhibits VEGFA isoform VEGF165-induced endothelial cell proliferation and migration.  Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2 (PubMed:12029087).  Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:11158588).  May negatively regulate the activity of homotrimeric non-collagenous domain 1 (By similarity).
What are the official names of this protein?
Collagen alpha-1(XVIII) chain.
What is the protein family that this protein belongs to?
Belongs to the multiplexin collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane. SUBCELLULAR LOCATION: [Non-collagenous domain 1]: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted. SUBCELLULAR LOCATION: [Endostatin]: Secreted. Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: SSRP_THEAB
Sequence: MKVIATNKKAYSDYNILETYEAGIELRGTEVKALRESGANFKDSFCRIKNGEVFLLNLNIPQYRNGNLNNHDPERPRRLLLHKKEIHRLIGKVKEQGLTIIPTKIYFNSRGLVKVEIAVAKGKKKYDKREDIKKREINRKINEYLKRNR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RL4_BARHE
Sequence: MDLLIKTLDGNEVGKLKVSESVFGLVPREDILQRVVRWQLARRQQGTHQSQGRSDVSRTGAKMFKQKGTGRARHSSARAPQFRGGGKAHGPVVRSHAHTLPKKIRALGLRFALSAKLKADDLIVVDEFNVKDAKTRMLVSCFSKLGFDNALLIGGNEVDLNFSRATSNIPNIDILPIQGINVYDILRRSKLVLSKAAVEVLEERFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PRIO_VULLA
Sequence: MVKSHIGGWILLLFVATWSDVGLCKKRPKPGGWNTGGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGGSHGQWGKPNKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPDQVYYRPVDQYSNQNNFVRDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRGASAILFSPPPVILLISLLILLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: APAH_SHEFN
Sequence: MAHYFVGDIQGCYSELQLLLQKVAFNPSKDQLWAVGDLVARGTESLATLRFFQSLQDSAKVVLGNHDLHLLALHGKLKRPHPQDHLDELLNAPDIDNLVNWLRQQPLVRTLPEHNIIMTHAGVPPQWDIAILEHEAEQVSFALQQDDYLSALIAQMYTEDAEHWSPSLHGIDRLRYCINALTRMRFLHLDGRLDFKCKLPPSEQHSTELRPWFEFASKTAPQNTLIFGHWAALMGQTGNPHVVALDTGCCWGEHLTLWHLEKNEIITQKRLI
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: RS19_BEII9
Sequence: MARSIWKGPFVDGYLLKKAEAARASTRSEVIKIWSRRSTILPQFVGLTFGVYNGHKHVPVSVTEDMIGHKFGEFSPTRTFHGHAADKKARRG
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SPZ10_ARATH
Sequence: MELGKSIENHNDVVVRLTKHVIATVANGSNLVFSPISINVLLSLIAAGSCSVTKEQILSFLMLPSTDHLNLVLAQIIDGGTEKSDLRLSIANGVWIDKFFSLKLSFKDLLENSYKATCSQVDFASKPSEVIDEVNTWAEVHTNGLIKQILSRDSIDTIRSSTLVLANAVYFKGAWSSKFDANMTKKNDFHLLDGTSVKVPFMTNYEDQYLRSYDGFKVLRLPYIEDQRQFSMYIYLPNDKEGLAPLLEKIGSEPSFFDNHIPLHCISVGAFRIPKFKFSFEFNASEVLKDMGLTSPFNNGGGLTEMVDSPSNGDDLYVSSILHKACIEVDEEGTEAAAVSVGVVSCTSFRRNPDFVADRPFLFTVREDKSGVILFMGQVLDPSKH
What is the function of this protein?
Probable serine protease inhibitor.
What are the official names of this protein?
Serpin-Z10, ArathZ10.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
Protein: RNG2A_XENLA
Sequence: MATPVNAQCSSKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEYEAHQDRVLAKLNRLHNQQALSSSIEEGLKMQAMHRAQRVRKHQHESDNTTFSGGEDNCDSRSHVSNPSVHSNQEAGPSRKRSRASEDSGAEPDLSHEGGVRSPDPPGGGETGSEIELVFRAHPLLVEKDGYSQTRYVKTTANATVDHLSKYLALRIALEEEVLRGEAEGVTLGEVSEKQYTIYICTGVAGGQYTTLNGSLTLELVNEKYWKVSKPLELYYAPTKEQK
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation.  H2AK119Ub gives a specific tag for epigenetic transcriptional repression.  Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.
What are the official names of this protein?
E3 ubiquitin-protein ligase RING2-A, RING finger protein 1B-A, RING1b-A, RING finger protein 2-A, RING-type E3 ubiquitin transferase RING2-A.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome.