Protein: CNOT1_CAEEL
Sequence: MHSTSGLAPVFRVEENHMIRNRENLERPISKKGTITLLSKMPMGFVLNSCSCAYIDNLLAHSSIHRVKPHSFMIQRLVVICGRSSPSLPNHAANIILSAFNFCQIEAPAKKFLEEDAALSLFHTILSYSTVTQINRSGIEILGAQRLTSALCDLIYAYTKTMDDMVASKTLTHLCKKLAGLFDPLVVLPFISKLAKSRRLRHYLQPLFLGHCEYTSDTWGVSPEGAEIYNQIARGNFTTQTLIEIVQTFLEKEVKEVIISSTTDPIKLVQYLISCSNPDNTEIVQALAFLLYSNTKLLPAGSGGTIDMDVQAADTITTARLGDTKFTQPVKDALLDSGREALLRRMEIYGVSLLSSVENFVTELKQAPIQKKMVTNNSVANAILYMLQYNFDMSRDIENGRQDNSPFWGGSNFVIGITRFVEEQQAAVRDMEGFSDWYPDINWVEVIKEFDSEEFAICRQTIIMFADIFPIMFQPQNFPVSFFLTPWRYYDHQLRLFEFMIEYADVWNISQYPHTKVLTPDLNLKTIPDDSTSVVQLWNCQEFSNCLLTIANSQPSLYNAIKQFYNVGSMQAGDVSMLALILSPTQWTTGRQDLIRHFLPSFILKSPNVTPVLNLVWNDTSLSKHMRQHVIYCLTSMHAADSSQLAKILDVAHDIKPTGLSELLNQAPKHLAFMVDLACLASKRDYLNLEKWIEDKEKAHGEAMTVAVLQFIQKKYQHAQLVAAIAPKTQATTPGAPSEPLQVLIPFVSKRARKPLRQQFPLVFQVMKENSGRSSSVSSGGHVQQSSGSQPQQQQFGGGSGLPPSGVVPVQQQPQQPPSLQQQHSQQSLPTPPTTSQQQIHVQQSVPGPIQRPAQFAPQPMFPPQAQAQHQHQHMMGQPPPSSQNAQPGMNLLMNMSPFASGNNRDLLKVVQPAPPPPSSMSPSTQMMRSLIPPLTQRQNSNSGWHAAPAPQRPSGPPTPQQQMDFRGQIQEFAPQGPHQLQRSGSVTGRSMGIVGQKTSSNFSVGAPIPGSAAATAAAAANVQQPMNEDFQSMTFAEDIQEEANSYFEKIYSVNNAMSVENLIDLLKRFRVSNDRRERLVLACVVKNLFEEYRFFHEYPERELRTTAAVYGGIIREDIISNVQFATAVRKVIESLSADPNTMLWTFGIVALQHCRSKLCAYPKVCQMIVSSENFARFPQLLKDYVIAGVKGELPPEGGRHTPVGSAQAGSASSTPTPAAAPTNWGAVARAASVDPKNSLPANRTGNVLSYTNVDTLVMATNKDGAEIAQPAEAIVDKISFLFNNLSQSNLIQKKDEVVEMISDHGDAFTLWLAQYIVMKRVSIEQNFQPLYNQFVNAIENPYLDQCIKRETFRNIRILLRTDKRTTVASNYSDRQLLKNLGSWLGAITIARNKPILLNDLDLKSLLLEAYYKGQAELLYVVPFISKILTACSKTSLFTPTCAWIRSILKVLAELHNEPDLKINLKFEIEVLCKELNVDLNQLQMDGILKDTEKLVRVPQQLCDVKLLTRPEAASPVQSKIHMSGSAEQLSGMSPAIPDQVKPATPQPTEAELQSGTGGGGSQGAEAQVVPNVTHFAYHDINVLTYDGLIPHVKIVSHLPLFQLHPHAKHLVRPAMIHAIKELIGPVTERALKIAMTVTESLVRKDFALDPEEQNLRAASFHMMRAMTAGMAMITCRDPLASSMHSNLANAFSSSLRSTAANPEMKQMIEDAAATITQDNVELSTNFIVKTACEKATQDIEKRLEADYQKRIAAKAEMSFYRDEIAAAIHAQLPKAIATVPGPTDKALMGIYDQFSSRICGFKANSGEDPVSAEPGSGAITPVQTQSKEMELVCQQLQVIIKEVDQTTQAQPHLSNSAFQTVCLMRELMQNVISTKDANHLMILVTRSTEHLLHAYRLEGTPPKNLLDVEWARRLRDLFIGLMRLLQNYFPLVELSRRITTAIMQIRSDYKWNMEGIEILFKQNLLQSVLWDQHLAGSMDNGGNMEAVLFAQKFVRSIGGGDMSRIQFLKERFPLTCEQLTKLHQLQSATRTEGMNNAMNNGAGNAAHHHAGLQQQPPVALPMEAAPMPQASADAMAQRGYDDQEMTAKVEIIMREWIGLCYSPTGQRSPQESLAQMIQLMHEHGVLATDDKITQFFRLCVENCVDISVRVMKSEQLANGLPTTLIRHRCYYTLDAFVKLMALMIRHSDNGQSQNKINLLKKLLNIIVGVLHMDHEVRKQDFNAMPYHRILISLFNEITGPDPLKLLEPIAWSILEAFGQTFFALQPRRMPGFAFAWLDIVGHRNVIGRLLANTGIAETVDAVKTAATYTQLIISHLKFLAPFLRNIQLPKSIAILYKGTLRVLLVILHDFPELLCEFHYVICDTIPPNCVQLRNLILSAYPRQMRLPDPFALNFKQVDTIPEMAVEPKSNLNMATIIPDNIRIPLDEYLANRISVDFLPNLPTLLQTQNQAGTKYNTTVMNALVLYVGIRAIEHLHLRRQRISTLNIAHTSYMDIFQNLAIQLDTEGRYLLFNGIANQLRYPNAHTHYFSCVFLYLFKNSTNDTIQEQITRILFERLVALRPHPWGLLITFIELIKNPTYNFWRYEFTSCAPEIQRLFQNVANTCVPAQGSQPQAQPDGAPGPLGNNTGAANQQQNPNTN
What is the function of this protein?
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:23843623, PubMed:28204614).  Positively regulates the accumulation of the CCR4-NOT complex component ccr-1 (PubMed:23843623).  Within the complex promotes germ cell development and fertility in hermaphrodites (PubMed:23843623).  Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).  Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs (By similarity).  Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex (Probable).  Acts as a transcriptional repressor (By similarity).  Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).  In embryos, plays a role in female pronucleus and mitotic spindle positioning during the first cleavage divisions after fertilization (PubMed:16971515).  This may partly be through negatively regulating the accumulation of zyg-9 at the centrosome (PubMed:16971515).  Negatively regulates the formation of long astral microtubules in developing embryos (PubMed:16971515).  Required for the stabilization and degradation of maternal mRNAs such as nos-2 in somatic blastomeres (PubMed:18692039).
What are the official names of this protein?
CCR4-NOT transcription complex subunit let-711, CCR4-associated factor let-711, Lethal protein 711, Negative regulator of transcription subunit 1 homolog, NOT1.
What is the protein family that this protein belongs to?
Belongs to the CNOT1 family.
What are the subcellular locations of this protein?
Nucleus.