PharMolix/UniProtQA huggingface dataset:
Protein: AXIN2_RAT
Sequence: MSSAVLVTLLPDPSSSFREDAPRPPVPGEEGETPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDGIKKQQIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVLCGYLPTLNEEEEWTCADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKRSEPVNPYHVGSGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGIPPYRMGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQIREDEEKEGSEQALSSRDGAPVQHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHQQCHALLPTGGKLPPEAACPLLGGKSFLTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSKCKSHSKPPEPLPGEQFCGSRGGTLPKRNTKGTEPGLALPAREGGMSSAAGAPQLPGEEGDRSQDVWQWMLESERQSKSKPHSTQSIRKSYPLESARAPPGERVSRHHLLGASGHPRSAARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNHPATGQAGPTSFSNPSLASEDHKEPKRLASVHALQASELIVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID
What is the function of this protein?
Inhibitor of the Wnt signaling pathway.  Down-regulates beta-catenin.  Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
What are the official names of this protein?
Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLOA_ALKMQ
Sequence: MTEFIPFIILIGVAFVILSIILSFVPVGLWITAQFSGVKVGIFTLVGMRFRRVQPIRIINPLIKATKAGIDINIDKLEAHYLAGGDVNTLVDALIAAQRAEINLPFERAAAIDLAGRQVLEAVQVSVNPKVIETPKIAAVAKDGIEVMARARVTVRANIERLVGGAGEETIIARVGEGIVTTVGSATTHKHVLENPDMISKTVLSKGLDAGTAYEILSIDIADIDIGRNIGAQLQTDQADADKRIAQAKAEERRAMAVAKEQEMKAAVQEMRAKVVEAEAEVPKALATALREGKMGVMDYYNMKNIMADTDMRDSISKVAPNEKKYEEE
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: BECN1_BOVIN
Sequence: MEGSKTSSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLATAQLKPGETQEEEANSGEEPFIETRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLGLELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
What is the function of this protein?
Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
What are the official names of this protein?
Beclin-1.
What is the protein family that this protein belongs to?
Belongs to the beclin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. SUBCELLULAR LOCATION: [Beclin-1-C 35 kDa]: Mitochondrion. Nucleus. Cytoplasm. SUBCELLULAR LOCATION: [Beclin-1-C 37 kDa]: Mitochondrion.
Protein: ACCD_SHIF8
Sequence: MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVELGSELEPKDELKFRDSKKYKDRLASAQKETGEKDALVVMKGTLYGMPVVAAAFEFAFMGVSMGSVVGARFVRAVEQAQEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPPRFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLMNLPAPNPEAPREGVVVPPVPDQEPEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIA1_YEAST
Sequence: MPRVESETYKRLQNDPSCIRNICIVAHVDHGKTSLSDSLLASNGIISQRLAGKIRFLDARPDEQLRGITMESSAISLYFRVLRKQEGSDEPLVSEHLVNLIDSPGHIDFSSEVSAASRLCDGAVVLVDVVEGVCSQTVTVLRQCWTEKLKPILVLNKIDRLITELQLTPQEAYIHLSKVIEQVNSVIGSFFANERQLDDLFWREQLEKNENAEYIEKDDSGIYFNPTDNNVIFASAIDGWGFNIGQLAKFYEQKLGAKRENLQKVLWGDFYMDPKTKKIINNKGLKGRSLKPLFTSLILENIWKIYQNIITSRDSEMVEKIAKTLNIKLLARDLRSKDDKQLLRTIMGQWLPVSTAVLLTVIEKLPSPLESQTDRLNTILVSESDTAAMDPRLLKAMKTCDKEGPVSAYVSKMLSIPREELPVESKRIASSDELMERSRKAREEALNAAKHAGMVENMAMMDLNDNSKNTSDLYKRAKDTVMTPEVGEQTKPKPSRNNDVFCVVSEPSSALDLEFEYEGEDDSDSQDNFGLDFVPTDIDPNDPLSSMFEYEEEDPLLESIKQISEDVNDEVDDIFDEKEECLVAFARIYSGTLRVGQEISVLGPKYDPKCPEEHIETAIITHLYLFMGKELVPLDVCPSGNIVGIRGLAGKVLKSGTLIEKGVQGVNLAGVNFHFTPIVRVAVEPANPVEMSKLVRGLKLLDQADPCVHTYVENTGEHILCTAGELHLERCLKDLTERFAGIEITHSEPAIPYRETFLSASDMNPPQNSQLGRGVHELLLSQYKITFRTFPLSGKVTDFLSQHQNSIKNILKTSTSSMDPVIESTGSSFLDKKSLLVAFEEVINQEEKSRELLSGFKVKLAGFGPSRVGCNILLSQDNLLGSLFEGTPAAFEYSDSIKNGFQLAVSEGPLANEPVQGMCVLVESVHKMSQDEIESIEDPRYQQHIVDLSGRLITSTRDAIHEAFLDWSPRIMWAIYSCDIQTSVDVLGKVYAVILQRHGKIISEEMKEGTPFFQIEAHVPVVEAFGLSEDIRKRTSGAAQPQLVFSGFECIDLDPFWVPTTEEELEELGDTADRENIARKHMNAIRRRKGLFIEEKVVENAEKQRTLKKN
What is the function of this protein?
GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes.  Together with SDO1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.  Inhibits GTPase activity of ribosome-bound EF-2.
What are the official names of this protein?
Ribosome assembly protein 1, EF-2-like GTPase, Elongation factor-like 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1280_BACCN
Sequence: MKVLAVTGYKPFELGIFQNDHPGVTYIKKALHRKFLAFLEEGLEWVMISGQLGVELWAAEVVFDLQLEYPDLKLAVFTPFLAQEENWKEENKEWYEFILEQADHVDSITKRRYESPEQFRLKNQFFIDKSDALLAVYDEEKPGSPKYIVEVAKKKEEIENYHSYFILFSDLQDIIEEEQWNDAE
What are the official names of this protein?
UPF0398 protein Bcer98_1280.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: RNPH_METFK
Sequence: MRPSNRAPDQLREVEIIRHYTKHAEGSVLVKFGDTHVLCTASVEDKVPPFLRGRNQGWTTAEYGMLPRSTGSRMDREAARGKQSGRTQEIQRLIGRSLRAVIDLGKLGERTIHLDCDVIQADGGTRTASITGAYVALHDAVGFMLANDMIQESPLRDAVAAISVGVYQGTPVLDLDYIEDSACDTDMNVVMTGSGGFVEIQGTAEGEPFQRAAMNRMLELAESGIRTLLLKQKEALGL
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: T2A1_ACICA
Sequence: MDYYDRIRELTKNVPVELVDFEQPRDLARTPTQASSNFITNKEQGDWAEDLVTRAINENSKNFVAVKYGKSDNLVAGENGFDTFYQDFQTELDTIGKRPDLLIFKKTDFDTTLGFDVSQIPHHQITDYVKKAIAGIEVRSSAFLIDKYEEAMQVRTQRFTEIAFQTRDKILAEFLDVLDHPSRSKYITLLNTLTLETISIFDFKVPGWRSNERLIEVNNLFKRLKVAIKEIQKRDYLSITPKVEDIKVVYKWIETFNVPHFYFQVFFDKVYGISFEQILTIISNSDNDGVIFSVEKDVQNQNKTTIKINSKTGYPIASKVDEPTHESIRKEMDRGRLLFYVTFKGGTAYLDLDNLRTILGIEEAEF
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GTMKAC-3' and cleaves after T-2.
What are the official names of this protein?
Type II restriction enzyme AccI, R.AccI, Endonuclease AccI, Type-2 restriction enzyme AccI.
Protein: LEUD_PARDP
Sequence: MDKFTTLTGIAAPMPLVNIDTDMIIPKQFLKTIHRSGLGKNLFDEMRYNPDGSEIPDFVLNQPAYRESQIIVAGDNFGCGSSREHAPWALLDFGIRCVISTSFADIFYNNCFKNGILPIVMPQEVVDVLMEDAKKGANARMTVDLENLTVTTSDGQSFPFELDPFRRHCLLNGLDDIGLTMEKAGAIDTYEAQMAQSRPWV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: GLMU_RUTMC
Sequence: MKNIHAIILAAGKGSRMNSSKPKVLQTLSNNTLLGHILSQVKGLCDKVHVVYGFEGNQVQRKINDSNINWVEQTEQLGTGHAVAQAMPHIEDNSISLILYGDVPLIKKSTLADLIHKAQQSGLSLLSVILDNPTGYGRIIRKDKQIQAIVEQKDATNTQLNINEVNTGIMAVHSQLLKQYLSKINSSNAQGELYLTDIIACAITDGQIVSSIISKNKFEIAGVNDKVQLAELERIFQINQATQFMQQGLSLKDPNRFDCRGVFTFGKDCEIDINALIEGEVVLGDNTIIAPNCIIKNSKIGNCISILSNCVIEDCVIEDGATIGPFARIRPNTHIKTYAKIGNFVEVKKSIIGENTNVSHLSYIGDAIIGKNVNISAGVITCNYDGINKHQTIIGDGAFIGSDSQLVAPIKIGKNATIGAGSTITKAAPDNQLSLSRTKQISLKNWQRPTKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYNS_SORMK
Sequence: MPEQQRLATLDSSIVSRLPAYSQSLFEAKTQKGLTFEAIAQHLGRSEVAVAGLFYGQVQASAEDVDKLSELLSVPKEAIAAQMMGFPDRGRAGPMPPVEPLIYRLYEIVQNYGYAFKAVMNEKFGDGIMSAICFNTTVDKEVDETGAAWVVITLKGKWLPFTRF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: TOP2A_OXYTA
Sequence: GKFSVFGKILRSIAKVFKGVGKVRKQFKTASDLDKNQ
What is the function of this protein?
Disrupts biological membranes, particularly those rich in phosphocholine.  Has antimicrobial activity against Gram-negative bacterium E. coli, Gram-positive bacteria B. subtilis and S. aureus, and hemolytic activity against sheep, pig and guinea pig red blood cells.  Has insecticidal activity against S. frugiperda ovarian cells by opening non-selective ion channels.  Enhances the insecticidal activity of spider venom neurotoxic peptides.
What are the official names of this protein?
M-oxotoxin-Ot2a, M-OXTX-Ot2a, Oxki2a, Oxyopinin-2a.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 02 (oxyopinin-2) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CRCB_ANAD2
Sequence: MARLLLVCLGGALGSGARYLTSAWALRAFGPDFPRGTLLVNVSGSFLLAGIMTASLQSEAVPPDLRLFLAAGVMGGFTTYSSFNYETLALVEQGRLAAAAAYLLATVLGCLAAAFAATLLVRWLAG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBE3B_MOUSE
Sequence: MFTVSQTSRAWFIDRARQAREERLVQKERERSAVTIQALVRSFLCRRRLHRDIRKEIDEFFSADESGSSKRSALCIFKIARRLLFICKTTEDSERLEKLCRSILNSMDAENEPKVWYVSLALSKDLTLLWIKQIKSILWHCCELLGQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPALNHICANIMGHLNQRGLYSVLQVLLTRGLARPRPCLSKGMLTAAFSLALRPVVAAQFSDNLMRPFIIHVMSVPALVAHLSTVAPERLGVLESHDMLRKFIVFLRDRDRCRDACESLEGCHTLCLMGNLLHLGSLSLRLLEEEMDGFVSALTQMLCYCQKYVAQKKSNLTHWHPVLGWFSQPVDYGLNDSMYLITKQLQFLWAVPLIRILFSDILSRKLLEHAEPAPVQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVGGRRVDSAEVRKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLKPGVLFQELDKDRRRAQLVLQHIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
What are the official names of this protein?
Ubiquitin-protein ligase E3B, HECT-type ubiquitin transferase E3B.
Protein: ATPG_VARPS
Sequence: MAAGKEIRGKIKSVENTKKITKAMEMVSVSKMRKAQERMRAARPYSEKIRNIAANLGKANPEYTHAFMKKNEAKAIGFIIVTSDKGLCGGLNTNLLRAVTGKLREAQSAGIAIESVAIGSKGLGFLNRIGARVVAHVTHLGDTPHLDKLIGPVKTLLDAYAEGKLSAVYLCYTKFINTIKQEPLVEQLLPLAADSLQVEAGQHSWDYIYEPDAQSVIDELLVRYVESLVYQAVAENMASEHSARMVAMKAATDNAGNVINELKLVYNKTRQAGITKELSEIVSGAAAAAGV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL6_THET2
Sequence: MSRIGRLPIPVPKGVSVEVAPGRVKVKGPKGELEVPVSPEMRVVVEEGVVRVERPSDERRHKSLHGLTRTLIANAVKGVSEGYSKELLIKGIGYRARLVGRALELTVGFSHPVVVEPPEGITFEVPEPTRVRVSGIDKQKVGQVAANIRAIRKPSAYHEKGIYYAGEPVRLKPGKAGAKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NRDR_ANAPZ
Sequence: MKCPFCNSADTRVKNSRHSDDNMSVRRRRLCEVCNSRFTTLEELLLKPIMVLKKDGRMEPFDKQKLLTSIMLATNKRPVTHAQINMVLSKILYKFESVKEDVIPARVIGEIVKNNLLVLDKVAYIRFVSVYMDFSDADDFCSLVEKIKEGSDK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PROB_ECOHS
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQMLLTRADMEDRERFLNARDTLRALLDNNIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPLENRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEVIRICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CK12_TRYBB
Sequence: MSVELRVGNRFRIGQKIGSGSFGEIFRGTNIQTGDPVAIKLEQVKTRHPQLAFEARFYRVLNAGGGVVGIPNVLYHGVEGEFNVMVIDLLGPSLEDLFSFCGRRLSLKTTLMLAEQMIARIEFVHSKSIIHRDIKPDNFLMGTGKKGHHVYIIDFGLAKKYRDARTHQHIPYKEGKSLTGTARYCSINTHIGIEQSRRDDLEGIGYILMYFLRGSLPWQGLKAHTKQEKYARISDRKQTTSVETLCRSFPAEFAAYLNYTRSLHFEDKPDYSYLKRLFRELFVREGYHVDYVFDWTLKRIHDTLQEGRADQQQQQQQQQQRRGSEKEDEHPV
What is the function of this protein?
Serine/threonine protein kinase (PubMed:19450734, PubMed:27002830).  May phosphorylate ZC3H11 during unstressed conditions, leading to proteasome-dependent degradation of ZC3H11 (PubMed:27002830).
What are the official names of this protein?
Casein kinase I isoform 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: BIOB_SHESM
Sequence: MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKDKDMPYLKQMVQEVKALGMETCMTLGMLSAEQANELADAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLSHVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPKSRVRLSAGRENMTDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAATIDDEQAVLAKAAAHQDKASAPFYDAAAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: TRMA_AZOVD
Sequence: MSLPHFDPSHYDAQLADKQARLSGLLAPFAAPEPEVFDSPREHYRLRAEFRLWREGEARHYAMFDPGDKRKPILLDDFPIASERINDLMPRLKAAWENAALGFKLFQVEFLTTLAGDALITLCYHRPLDTFWQTAAERLAAELGVSIVGRSRGQRLVVGRDYVEEELEVAGRRFRYRQPEGAFTQPNGVVCRKMLNWAHDVLGERDDDLLELYCGNGNFTLPLATRVRRVLATEISKTSVNAALTNLESNGVDNVTLVRLSAEELTQALNEVRPFRRLAGVDLKGYDFGSLFVDPPRAGMDPDTCELARRFGRILYISCNPETLAANIARLHDTHRVVRCALFDQFPYTHHMESGVLLERR
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: NUOH_EHRRW
Sequence: MHNYNIFLSFYNYISSGVLLFLKIIIVIISVMVSVAYLVYMERKVIAAIQLRQGPSVVGPFGLLQPFADAIKLIIKEPIIPFKANKLCFLIAPVITFTLALLGWAVIPFGSYIIVDNGQELIVPNVIANINIGVLYILAISSLGVYGIIIAGWSSNSNYAFLGAIRSASQMISYEVSIGLTIVTVLLATGSLKLGEIVIARHNMPYWIDLLLLPMAFMFFISALAETNRHPFDLPEAESELVSGYNVEYSSMPFALFFLGEYANMILMSAMAVIFFFGGWYPPLNVSFLYIIPGTIWFIFKIVILLFCFIWIRASIPRYRYDQLMRLGWKVFLPISLFWVILVSGILVYTDSLPKNTLNNTVYYKEN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: G6PI_STAAR
Sequence: MTHIQLDFSKTLEFFGEHELKQQQEIVKSIHKTIHEGTGAGSDFLGWVDLPVDYDKEEFSRIVEASKRIKENSDVLVVIGIGGSYLGARAAIEMLTSSFRNSNEYPEIVFVGNHLSSTYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVEERYGKEEAQKRIFATTDKEKGALKQLATNEGYETFIVPDDVGGRYSVLTAVGLLPIATAGINIEAMMIGAAKAREELSSDKLEENIAYQYATIRNILYAKGYTTEMLINYEPSMQYFNEWWKQLFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKYDITIEKDSDDLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNMVVNIPQLDEETFGYVVYFFELACAMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDLKKELEERL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOA1_PARXL
Sequence: MNEKSRKIYVSDVTLRDGMHAIRHQYSLADVGRIARALDQAGVDSIEVAHGDGLRGSSFNYGFGAHTDLEWIAAVAEVVEQAKIATLLLPGIGTIHDLKAAYDAGARVVRVATHCTEADISRQHIEYARSLGMDTVGFLMMSHMTTPENLAVEARKMESYGATCIYVVDSGGAMNMNDIRDRFRALKEALDPATQTGIHAHHNLSLGVANSIVAVEEGCDRVDASLAGMGAGAGNAPLEVFIAAAERLGWNHGTDLYALMDAADDIVRPLQDRPVRVDRETLALGYAGVYSSFLRHSEVAADRYGLKAVDILVELGRRKMVGGQEDMIVDVALDLLRNPA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 1, HOA 1, 4-hydroxy-2-keto-pentanoic acid aldolase 1, 4-hydroxy-2-oxopentanoate aldolase 1.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: GATC_ORYSI
Sequence: MLSAAASAIPRLRWAAPPRNQSARNQWLLLRRRSLSSSPPYVTPGIPAAAAAAGSGALEPPDLPRLANAARISLSPEEAEEFAPKIRQVVDWFGQLQAVDLESVEPSLRAGTAAGNSLREDRPETFTNRDAIIESVPSYDDPYIKVPRVLNKE
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit C, chloroplastic/mitochondrial, Glu-AdT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
What are the subcellular locations of this protein?
Mitochondrion. Plastid, chloroplast.
Protein: PRVA_RAJCL
Sequence: SSKITSILNPADITKALEQCAAGFHHTAFFKASGLSKKSDAELAEIFNVLDGDQSGYIEVEELKNFLKCFSDGARVLNDKETSNFLAAGDSDGDHKIGVDEFKSMAKMT
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin alpha.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: MEX1_DROME
Sequence: MCNALCECLKCPGKVVCCCCSCACKMLLSIVFSALLMVVVIGLIVYFTVFYHKDKNTDEVQKQVAQLTPIVKRSIRDYFNKEY
What is the function of this protein?
Involved in morphogenesis and development.
What are the official names of this protein?
Protein midgut expression 1.
Protein: MCFM_DICDI
Sequence: MRYILNNNVEGTSALLGSTVATAFLQPFDFLKIRLQGSGFASGGDLNKFKRVGVIDTCKNVLKNEGIKQFWRGSSPTIVASGIAWGTYMHFYEAYKNILKSKYNVTQLNTFDHFICAVGASATQVFITNPIFLIKTRMQLQTPGSANYYTGIFDGIKKTVKVEGFKGLYKGVIPSLWLTFHGGIQMSSYEHIKFYFSSNSGKSLDSLNASEIFIASSISKFLASTILYPFQVVKTRLQDERNIPNQNNVRVYNGTKDVIFKILKNEGIIGFYRGLVPNTLKVIPNTSITLLLYEEIKKSFNYIINE
What is the function of this protein?
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.  Transports folate across the inner membranes of mitochondria (By similarity).
What are the official names of this protein?
Mitochondrial substrate carrier family protein M, Solute carrier family 25 member 32 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.