PharMolix/UniProtQA huggingface dataset:
Protein: RFA1_TETTS
Sequence: MVTQLTKNAIDSLINSTNPDEQYVIQVLKAPQSVAENLFKICISDGFCKFKKGYFVSDAATKCQDLKDLCIIKCKKYIDDSNHDKERIIISNYELIYSNIQEQIGKPIEYKQYKSSGFSNPEGSTVIPSQYLSRNAQILQQNQVSQPKQMVTPPVSNINKPTPAVNNTFAQKPAVTNQNIQRVNQNPQQMNKTAPVKQNNNNNNNNNGNNKNNSSLQISTDGDEQNLEYIRNLQPNGQPQTIKVRITKKGDLKSFKEKQGKLFSIDVIDKFGDECSISFFNEIAEQYDGLFKVGQVIVLKQFSVKVNNNHQYNKGDHTVTVNKESKILICQEDPSIPMIKLNRQFIQDMQNKQKGDLIDLIVVVKADTEVKTMILKKDNQQQSKRDIISFDESLIETEITLWGETAKDYDAKQGDIIVFKDAKIGEFKDKKQINIGYGTQIFMNPDEQLFPQIHDVKKWYLSLNSDQLSTIQKAQGNDTGPREVTSFESSLNILKEEIKNLQTDPEMKIWKEIRGQIMYIKDTPLYYNACFSCKKKIARNNEVWTCINCNKDFNEPDSRYILSLNISDSTDTIWVSAFDEVGQKILGVKGDVFRYADEDTEHGTETKKKLLMAAQNKEYRFLLLTKQERDQNGNARDKTVIHAIKDFQPAYEAKKIINSLEKFMVIEENNP
What is the function of this protein?
As part of the heterotrimeric replication protein A (RPA) complex, binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress (By similarity).  It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (By similarity).  Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (By similarity).  In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation (By similarity).
What are the official names of this protein?
Replication protein A 70 kDa DNA-binding subunit, RP-A p70, Replication factor A protein 1, RF-A protein 1.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 1 family.
Protein: YTFE_ECODH
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF2M_DROPS
Sequence: MLKYALHSGGMPRNRLLRQLSAHIFRRSYSSNIRNIGILAHIDAGKTTTTERMLFYSGKTRSLGEVHRGNTVTDYLTQERERGITICSSAVTFPWRGNRINLLDTPGHIDFTMEVEQSLYAVDGVVVVLDGTAGVEAQTVTVWTQADKHKLPRLAFVNKMDRPDADFDKCVNDLRTKLETQPVCIQYPSKNQDGLLTINDVITLEQLTWQPKDLGRSYSKTKLEPSDDLRQLQEKRNELIDQLSGLDDELADVVISTESFDNVSNALIERALRRATCQQKVVPVLLGSAYKNVGIQRLMDAVNTYLPAPEERNQIYDCFGNEVAGKVFKIVHDKQRGPLTLVRILRGEIKRGMRLICSRGQAEVVSKLYEPLADEYREVGAVQSGDVVICAGLKSTVTGDLLTSSQTALRNAQKRLKQSQGTVSPDEDEELDTDELFGIDRQIPDAVYFCSIEPPSVSSQTAMEQALRQLQREDPSLRVSYDSVTGQTVLGGMGELHMDIIKSRILSEYKIDVDLGPLQIAYKETIESPSLTTLSVEKEIAGSKQNVSLTLEVVKDQGELFSLDKSPENLSNLNTLRPRTLQVIRKGSVSALERGPRVGGQVVDTQIRLHNAIIGRGTADSFVMATAAQCVQKLLSTSGTRLLEPIMALQIVAPSERISGIMADLSRRRALINDVLPKGERNKMILVNAPLAELSGYSSALRTISSGTASMTMQPSGFSGMNAVDESLAERRVQGLE
What is the function of this protein?
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.  Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
What are the official names of this protein?
Ribosome-releasing factor 2, mitochondrial, RRF2mt, Elongation factor G 2, mitochondrial, EF-G2mt, mEF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SOX14_DANRE
Sequence: MSKPADHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDHLKGLPVSATDSLLGSSEKARAFLPPTSAPYSFLDPSQFSSSAIQKMTEMPHTLATSTLPYASSLGYQNGAFGSLGCPSQHTHTHPSPTNPGYVVPCNCTAWSASSLQPPVAYILFPGMTKSGIDPYSSAHAAAM
What is the function of this protein?
Acts as a negative regulator of transcription.  May function as a switch in neuronal development (By similarity).
What are the official names of this protein?
Transcription factor Sox-14.
What are the subcellular locations of this protein?
Nucleus.
Protein: MEPCE_MOUSE
Sequence: MIEMAAEKEPFLVPAPPPPLKDESGGGGGPEVQSHQEAASGELRDGTEHGPGPRAHSAGAAASGGGGPQAQAHGEPHGRAAAPADVGEERRGGGGTDLGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGSGGSFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSLLDEEVSRALNAETPKSSPLPAKGRDPVEILIPKDITDPLSLNTCTDEAHVVLASPLKIGRKRHRHRGPHHQQQQQASGGNDSNAAVLPTDPLTPSLHGEGATQQQQNRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGSSGSLSAPPAASVTSAPSTSSSSRHRKRRRTSSKSEAGARGGSQGSKEKGRGSGGGRHHHHPLPATGFKKQQLKFQYGNYCKYYGYRNPSCEDVRLRVLKPEWFQGRDVLDLGCNVGHLTLSIACKWGPARMVGLDIDPRLIHSARQNIRHYLSEELRLQAQTSEGDPGTEGEEGTITVRKRSCFPASLTASRGPIAAPQVPLDGADTSVFPNNVVFVTGNYVLDRDELVDAQRPEYDVVLCFSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYCKRKSLTETIYKNYFRIQLKPEQFSSYLTSPEVGFSSYELVATPNNTSRGFQRPVYLFHKARSPSH
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (By similarity).  Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:23154982).  The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity).  In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (By similarity).  MEPCE has a non-enzymatic function in the 7SK RNP complex; it has a non-enzymatic function; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (By similarity).
What are the official names of this protein?
7SK snRNA methylphosphate capping enzyme, MePCE.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TATA_SHIFL
Sequence: MGGISIWQLLIIAVIVVLLFGTKKLGSIGSDLGASIKGFKKAMSDDEPKQDKTSQDADFTAKTIADKQADTNQEQAKTEDAKRHDKEQV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NREB_ARCFU
Sequence: MDCIECRGRMLCSRKVCPLMPSLRPQVSVERDILGSSPPSVFVGRYGYPKVRICPAVPPFTGDTKIYDTPEMWREVPVERVLEFRYSMILGQFRADVRRSKEVEVVQEMSLYDKPIDVEVSFAKPPSVRAFFDDVLPPFGASAPAKEVIIHSAPRPPKAVEKVYYDTDLRAVEAMSYLYERGVAVSHIQKLLSAGTLGVKRKLVPTRWAITAVDDTLSKQIIEEIKQYETIDRYRVFVLKESKNLFVAILCPSPWSYEWGEAWYPDTTWNRTRKVGVLTDSEGFFGRTTYARLGGCYYSSRLATAEYLRRIRRQATAIVWREIYPGFNVPIGVWFVREMLRKMYAGKYCEFDTLEDALRFVDKHSNLDVGRWIEKSTLVKRGRQRTLWEFM
What is the function of this protein?
Involved in DNA damage repair.
What are the official names of this protein?
DNA repair protein NreB.
What is the protein family that this protein belongs to?
Belongs to the Nre family.
Protein: PGP3_CAEEL
Sequence: MKKTKVNPEDDITLGKFTPKPSPQDSYQGNFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFDETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKEDTTLDDEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALLLVVVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS
What is the function of this protein?
Mediates ATP-dependent export of organic anions and xenobiotics from the cytoplasm.  Hydrolyzes ATP with low efficiency (By similarity).
What are the official names of this protein?
Multidrug resistance protein pgp-3, P-glycoprotein C, P-glycoprotein-related protein 3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL9_SINMW
Sequence: MEVILLERIAKLGQMGETVKVRDGFARNYLLPLGKALRANASNKARFEAERSTLEARNLERKSEAQKVAESLDGKSFIIVRSAGETGQLYGSVAARDIVETLAAEGFNINRNQVDLNQPIKAIGLHTVTLHLHGEVDVAIEINVARSAEEAERQAKGESLTSADAIYGVDEDALKPEDFFNPEAEIESEEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: Y1271_MYCTU
Sequence: MLSPLSPRIIAAFTTAVGAAAIGLAVATAGTAGANTKDEAFIAQMESIGVTFSSPQVATQQAQLVCKKLASGETGTEIAEEVLSQTNLTTKQAAYFVVDATKAYCPQYASQLT
What are the official names of this protein?
Uncharacterized protein Rv1271c.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1291c.
Protein: HSSR_STAS1
Sequence: MTTCLIVDDDPKILEYVSKYIEREHFETIVQSSAENALSYLETHQVDIAIVDVMMGKMSGFELCKILKEDFDIPVIMLTARDALSDKEQAYLTGTDDYVTKPFEVKELMFRIKAVLKRYNVNINNEVSIGNLTLNQSYLEIQSSSKSMNLPNKEFQLLFLLASNPRQVFNRDALIEKIWGFDYEGDERTVDVHIKRLRKRLEKIDASVTIHTVRGLGYKVDDHV
What is the function of this protein?
Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence.  Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity).
What are the official names of this protein?
Heme response regulator HssR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_BIFLS
Sequence: MSLAVRVIPCLDVDAGRVVKGVHFENLKDAGDPVELAAEYYRQGADEITFLDVTASSSHRNTMIDVVSRTAEQVFIPMTVGGGVRTPEDVDSLLRCGADKVGVNTAAINDPSLISRVADRFGNQVLVLSVDARREKGEQHTQSGFEVTTMGGRKSTGIDAIWWVKRAEQLGAGEILLNSMDADGTKEGFDLEMIRAVRKEVKIPIIASGGAGKVEDFPPAIEAGADAVLAASVFHYGILTIADVKAELKKHGYTVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1955_STAA2
Sequence: MVRESIPKEGENIKIQSYKHDGKIHRVWSETTILKGTDHVVIGGNDHTLVTESDGRTWITREPAIVYFHSEYWFNVICMFREDGIYYYCNLSSPFVCDEEALKYIDYDLDIKVYPNGKYHLLDEDEYEQHMNQMNYPHDIDIILRRNVDILQQWIEQKKGPFAPDFIKVWKERYKKIRQY
What are the official names of this protein?
UPF0374 protein SaurJH1_1955.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: IL2_MACNE
Sequence: MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRDTKDLISNINVIVLELKGSETTLMCEYADETATIVEFLNRWITFCQSIISTLT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NQOR_NITOC
Sequence: MTKLLVLYYSMYGHVETMAHAVAEGARSVEEVEVTLKRVPELMPEEIARNAGAKLAQEAPIATVDELPEYDAIIFGTPTRFGNMCAQMRNFLDQTGKHWMSGALIGKVGSVFTSTASQHGGQETTITSFHSTLLHQGMVIVGVPYSCQALLNMNEITGGSPYGASTLADADGSRQPSENELTIARFQGEHVAKFTKKVVE
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: PER7_ARATH
Sequence: MKLAVVSVVVILGVLVAWPVSAGRKDLPGAGGYGGDDDDDTKSLFPLDNLLSLNYYDRICPDFEKIVVTKVREWTKSDSSLGPALLRLIFHDCGVTGCDASVLLDYEGTERRSPASKTLRGFELIDDIKSEMEKSCPGKVSCADILTSASRAATVQLGGPYWPNVYGRRDSKHSYARDVEKVPSGRRDVTALLETFQSYGLNVLDLVVLSGAHTIGKASCGTIQSRLYNYNATSGSDPSIDAKYADYLQRRCRWASETVDLDPVTPAVFDNQYYINLQKHMGVLSTDQELVKDPRTAPLVKTFAEQSPQIFRQQFAVSMAKLVNVGVLTGEDRVGEIRKVCSKSNSRAY
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 7, Atperox P7, ATP30.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BIN3D_SCHPO
Sequence: MSNFQHGNYHSYYSMRGGTSIIDPRLKCLPDSLFYEASVLDIGCNNGTVSAQIASIFGASFVLGLDIDHVLIQKARKHLEFVSSRIGPVRNPGSIVEDQFNYYPISSIKKFSRIPVQLQPPLNKQNFPHNIEFETADFLRWESKRKFKIILALSVSKWVHLNNHDEGIIKFFGKISSLLETNGVLILEPQGWDSYLKAAKKISVFNQTPENLKIQPDAFEHLLNQAGLVLEYSIEPQVNNSEYKNFAKRTMYIYKKKGIGIIKLLTST
What is the function of this protein?
Probable RNA methyltransferase.
What are the official names of this protein?
Probable RNA methyltransferase C2A9.10.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: HISX2_NOSS1
Sequence: MLRIITQQADVKAELQRICDRTHDEQVLHKEATVREVLQAVKRQGDKAVLHYTDEFDNQILKAEELRVTGSELDAAYQQVSQELLEAIQLASRQIEAFHRQRVPKSWVHFGDDDIVLGKRYTPIDRAGLYVPGGRAAYVSTVLMNAIPARVAGVPRIVIATPPGAQKAINPAVLVAAQEVGVQEIYRVGGAQAIAALAYGTETIPKVDVITGPGNIYVTLAKKLVYGNVGIDSLAGPSEVLIIADEGANPVHVATDMLAQAEHDPMAAAILFTTDPALAKNVQVAVERQLVDHPRRIDTEKAIAHYGLIVLVESLDAAAELSNEFAPEHLELEVKDPWAVLPNIRHAGAIFLGYSTPEAVGDYLAGPNHTLPTSGAARYASALSVETFLKHSSIIQYSQTALNKVAGAIDALATAEGLPSHADSVKRRIQQDE
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase 2, HDH 2.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: PKNL_MYCTO
Sequence: MVEAGTRDPLESALLDSRYLVQAKIASGGTSTVYRGLDVRLDRPVALKVMDSRYAGDEQFLTRFRLEARAVARLNNRALVAVYDQGKDGRHPFLVMELIEGGTLRELLIERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPFTGDSALSIAYQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLEAIAEELALPEFRVPAPRNSAQHRSAALYRSRITQQGQLGAKPVHHPTRQLTRQPGDCSEPASGSEPEHEPITGQFAGIAIEEFIWARQHARRMVLVWVSVVLAITGLVASAAWTIGSNLSGLL
What is the function of this protein?
Phosphorylates the DNA-binding protein MT2231.  May be involved in the regulation of cell division and cell envelope biosynthesis (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PknL.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: QUEF_ALKEH
Sequence: MSTQPSKDLETFPNPRPERDFVLHMRIPEFTCLCPKTGQPDFATIHLDYVPDERCVELKSLKLYMWSFRDQGAFHEAITNEILDDLVRATEPRYMKVTAEFYVRGGIYTTVVAEHRKPGWAPAPKVELA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESM7_DROME
Sequence: MATKYEMSKTYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKLKESKKHVPANPEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQLEQPMEQPQAVNTPLSIVCGSSSSSSTYSSASSCSSISPVSSGYASDNESLLQISSPGQVWRPW
What is the function of this protein?
Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo.  Transcriptional repressor.  Binds DNA on N-box motifs: 5'-CACNAG-3'.
What are the official names of this protein?
Enhancer of split m7 protein, E(spl)m7.
What are the subcellular locations of this protein?
Nucleus.
Protein: SAHH_CHLPM
Sequence: MTIAATALDYKVADISLAEWGRKEIDIAEKEMPGLMAIRNKYKGQKPLAGSRISGSLHMTIQTAVLIETLVELGADVRWASCNIFSTQDHAAAAIAVTGVPVFAWKGESLEEYWWCTRQILDFGNGLGPNLIVDDGGDATMMIILGYKVENNPSMFDKGGSNAEEKALFAQLKSIYDEDSTRWHKVAADMKGVSEETTTGVHRLYHMMEKGELLFPAINVNDSVTKSKFDNLYGCRESLADGIKRATDVMIAGKVAVVLGYGDVGKGCAHSMRSYGARVIVTEIDPICALQAAMEGFEVTTMDRAVKEGNIFVTTTGNKDVITLEHMKQMPDEAIVCNIGHFDNEIQVEPLNEYKGATKLNIKPQVDKYTFEDGHCIYMLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELWKNDYEIGVYRLPKALDEEVARLHLEQIGVKLTTLSKEQADYIGVPVSGPYKPEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_HAEI8
Sequence: MIDFRPFYQQIATTNLSDWLETLPLQLKEWETQTHGDYAKWSKIVDFLPDLHADEIDLKSAVKSDRTFPLSEGEKQRIIHHLKQLMPWRKGPYHLFGIHVDCEWRSDFKWDRVLPHLAPLQGRTILDVGCGSGYHMWRMVGEGAKMVVGIDPTELFLCQFEAVRKLLNNDRRANLIPLGIEQMQPLAAFDTVFSMGVLYHRKSPLDHLSQLKNQLVKGGELVLETLVVDGDVNTVLIPADRYAKMKNVYFIPSVAALINWLEKVGFTNVRCVDVATTTLEEQRKTDWLENESLIDFLDSNDHSKTIEGYQAPKRAVILANK
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: YH10_YEAST
Sequence: MSNNKAGGEYEVITIGDAKKLQATISELGATLLDLKVNNESIVLGYPDIHGYISDGYNYIGATVGRYANRIYKGMFSMEDGPHQLTVNNCGNTNHSSISSFHLKKYKASKVQNPLDDLYIVEFTLLDDRTLPNEFPGDLAVNLKYTLNVADMTLDLEYEAKLVSGEATPINMTNHTYFNLNKTMDKKSISGTEVRLCSDKSLEVSEGALIPTGKIVQRKIATFDSSKPTILQDDGPIYDYAFIVDENKNLKTTDSVSVNKLVPAFKAYHPASRLSLEVSTTEPTVLFYTGDNLCDGFTPRSGFAVEQGRYVDAINRDGWRDCVLLRRGEVYTSKTRYRFAV
What are the official names of this protein?
Uncharacterized isomerase YHR210C.
What is the protein family that this protein belongs to?
Belongs to the aldose epimerase family.
Protein: SLX1_YEAST
Sequence: MSQKIQQHQFPDFYCCYLLQSINKRQSFYVGSTPNPVRRLRQHNGKLAVGGAYRTKRDGSRPWEMIMIVRGFPSKIAALQFEHAWQHGYQTHYIAEKDRVVKHKAGGRTLHHKVALMKLLLKHEFFQRMNLIVEVFNIKAWEVWKQDKFFIERDRFPINIQINENALEEPKEKTVDVLMDHSDENLKVVEAVYTKVIENERNIFETFEKKLTTGVVRCEICEKEIDYTSEEQNLKPFVALCNNKDCGCVNHLKCLHRYFLDDEQLMVGRRNLIPRGGKCPKCDMFCDWTTLVKFSTRMKLAHGK
What is the function of this protein?
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.  Has a preference for simple Y, 5'-flap and replication fork-like structures.  It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates.  Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks.  Has Holliday junction resolvase activity in vitro.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1, Synthetic lethal of unknown function protein 1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.