PharMolix/UniProtQA huggingface dataset:
Protein: CYOE_BUCCC
Sequence: MIKPGIILGNIICLSGGFFLALNEKLSKIFFLKTVFGLILIISSSCILNNIIDRDIDKKMNRTKNRFLCINTNVFLLKILFFFSIILLILGLLVFYIYINFLCTIISFFGFFFYVYLYSYLFKRKTYFSTFVGSVSGSLPPIIGYVAVNNCLNRCCTILFFMFSFWQIAHSYSIIIYRYSDYKLLNLPVFPILYGKLKTIIFISICILNLFFFNFLLYFFGYVKFFYFLYTSFFIFLWFIFSFLSNSRYFTIKIWSRIMFFFSIFIIFMISFLMSLNNF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL40_DICDI
Sequence: MQIFVKTLTGKTITLEVEGSDNIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIEPSLVILARKYKCDKMICRKCYARLHPRAVNCRKKKCGHSNNLRPKKKLLK
What is the function of this protein?
Component of the 60S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-60S ribosomal protein L40, Ubiquitin A-52 residue ribosomal protein fusion product 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [60S ribosomal protein L40]: Cytoplasm.
Protein: DBP2_CRYNJ
Sequence: MSYGGGYGGGGYGGGYGGGGGGGGYGGGGGGYGGGYGGGGYGGGFGGDRMGNLGQGLHNIDWQNQSLAKFEKNFYVQDPRVTARSDAEVEAFRAEKEMKIQGKNVPRPITTFEEAGFPDYIMSEIRRMGFTAPSSIQCQAWPMALSGRDLVAIAETGSGKTISFCLPAMVHINAQPLLAPGDGPIVLILAPTRELAVQIQTEATKFGQSSRIRNTAIYGGAPKGPQIRDLQRGVEICVATPGRLIDMLETGKTNLKRVTYLVMDEADRMLDMGFEPQIRKIVSQIRPDRQTLLFSATWPKEVQRLAMDFLHDFIQVNIGSLDLTANHNVAQHVEVCTDFDKRSKLLSHLEKISQENGKVLIFVATKRVADDLTKFLRMDGWPALAIHGDKQQAERDWVLAEFKSGRSPIMLATDVASRGLDVRDIGYVINYDFPNNCEDYIHRIGRTGRAGRKGTSYTYFTMDNSKAARELVQILRESKADIPPELEEMAMYGGRGGGGGRGRGGRGGGRGGYGGGGGRGGYSSGANSYGGGGGGYSSRW
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
ATP-dependent RNA helicase DBP2-A.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GLGS_ECO55
Sequence: MDHSLNSLNNFDFLARSFARMHAEGRPVDILAVTGNMDEEHRTWFCARYAWYCQQMMQARELELEH
What is the function of this protein?
Major determinant of cell surface composition.  Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.
What are the official names of this protein?
Surface composition regulator.
What is the protein family that this protein belongs to?
Belongs to the GlgS family.
Protein: NIT3_YEAST
Sequence: MSASKILSQKIKVALVQLSGSSPDKMANLQRAATFIERAMKEQPDTKLVVLPECFNSPYSTDQFRKYSEVINPKEPSTSVQFLSNLANKFKIILVGGTIPELDPKTDKIYNTSIIFNEDGKLIDKHRKVHLFDVDIPNGISFHESETLSPGEKSTTIDTKYGKFGVGICYDMRFPELAMLSARKGAFAMIYPSAFNTVTGPLHWHLLARSRAVDNQVYVMLCSPARNLQSSYHAYGHSIVVDPRGKIVAEAGEGEEIIYAELDPEVIESFRQAVPLTKQRRFDVYSDVNAH
What is the function of this protein?
Possesses omega-amidase activity (PubMed:28373563).  The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
What are the official names of this protein?
Omega-amidase NIT3, Nitrilase homolog 2.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Protein: FOLD_LEPIC
Sequence: MNPVLLDGKKLSEKIKEEIRSAIEERKTKNFRIPKLATILVGNNPASETYVSMKVKACHSVGMGSEMIRLREQTTTKELLDVIDKLNSDPNVDGILLQHPTPSGIDERAAFDRIALHKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVAGKNAVVVGRSPILGKPMAMLLTEMNATVTLCHSKTQNLPDIVRNADIIIGAVGKPEFIKADWISNGAILLDAGYNPGNIGDIEISKAKDRSSFYTPVPGGVGPMTIAVLLLQTLYSAKEHFTPPVK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: IHFA_ACIB3
Sequence: MTALTKADMADHLSELTSLNRREAKQMVELFFDEISQALIAGEQVKLSGFGNFELRDKRERPGRNPKTGEEIPISARRVVTFRAGQKFRQRVGNEQID
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RUVB_SYNJB
Sequence: MAIISSRDTGQNAEGPKRRQQKSSAWRKEVRELSFAGERGADPSALLQPQAHPGEAQEESLRPRTLAEYIGQTELKEVLSIAIAAARARQEPLDHLLFYGPPGLGKTTVAAVLAAEMGSQFYMTTAPALESPRDIAGYLVRLKRGDVLFIDEIHRLPKVTEELLYPAMEDFRLDITIGKGRSARITSLPLERFTLIGATTRIGALTSPLRDRFGHVQRLRFYEPHELVQIVLRTARLLNVSTDPEGAAEIARRSRGTPRIANRLFKRVRDYAQVRGDGHISQEVAAAALELFQVDPMGLDWIDRKLLTVLVEQFGGGPVGLETMAAVTGEDPQTIEEVYEPYLLQIGYLQRTPRGRVVTPAALRHLGYEAQSPLPLWS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: GPMA_BORAP
Sequence: MYKLVLVRHGESEWNKENLFTGWTDVKLSDKGVDEAIEAGLLLKQEGYFFDIAFSSLLSRANDTLNIILKELGQSYISVKKTWRLNERHYGALQGLNKSETAAKYGEDKVLIWRRSYDVPPMSLDESDDRHPIKDPRYKYIPKRELPSTECLKDTIARVIPYWIDEIAKEILEGKKVIVAAHGNSLRALVKYLDNLSEEDVLKLNIPTGIPLVYELDKDLNPIKHYYLGDENKIKKAMESVASQGKLR
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: Y1518_ALCBS
Sequence: MKVETPVSGVGLGLRRALMGPLSQARDYAPESIPFDFMEVAPENWIPMGGRQGKEFRAFTERYPFVAHGLSLSLGGPEPLDFELLKSVKSFLKQHNIRRYTEHLSYCSDHGHLYDLMPIPFTQEAVYYVADRIRQVQDFLEQPIGIEHVSYYAQLGNAALGAQMSEIDFVNAVLKEANCELLLDVNNAYVNGINHGYDPLDFISALPGERICYLHIAGHFDEAEDLKVDTHGSDVIDPVWALLDHAYQTFGSLPTLLERDFNIPDNATLFAELRKIGGYQQLYPSAAIKSEDWQKPAQP
What are the official names of this protein?
UPF0276 protein ABO_1518.
What is the protein family that this protein belongs to?
Belongs to the UPF0276 family.
Protein: VE4_HPV1
Sequence: MADNKAPQGLLGLLQYTPTTQPYPRVTPPSNRRPSTTPNSQDRGRPRRSDKDSRKHLYADGLTDGEDPEVPEVEDEEKENQRP
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: BRAB_ANNTR
Sequence: MVPSVMEGAPQLGITSTDTSSAGVPPGLKLIPTDRLDRRTDEEIAAWLQTRHPVTSDKNVWAFWHNGYTNMPPWVQRNIINWVRRLGPDWTVHLLDRVDGSATNVSHYVDSSFFPECFNNNTMDGPTVGQHSGDLVRLPLLWLYGGIWIDAGSFLFRHVEDICWNKIEDPESPYEMAGFVIEMRPGVEVMLNGFIAAKRGNPFIKRWLEIFKKLWDGATNVQGFHKHPLLRHLPMLCPPIDKLNLPPQGLNVVMEQFTDYMSQIMSFERLRKLVDPSDGFNGPEYYSNKMLLCSALQETFYFQLVTEWSGTKQFNLLSTKRKGEGVVKDENWHAAENFVHDALANTATMKLSHGPPGALDSFLADLWDSEEHHGKDNEDGTFAAYLRYGSVHFDQTREMVPIKMGWPDEEVLEAGVLEPKK
What is the function of this protein?
O-glycosyltransferase; part of the gene cluster that mediates the biosynthesis of the brasilane terpene glycosides brasilane D and E (PubMed:32936132).  The biosynthesis starts with the activity of the terpene cyclase braA that converts farnesyl pyrophosphate into the sesquiterpene alcohol trichobrasilenol (PubMed:32936132).  Subsequently, trichobrasilenol is glycosylated by the O-glycosyltransferase braB putatively using UDP-GlcNAc as sugar donor to yield brasilane A (PubMed:32936132).  The latter then undergoes two rounds of oxidation performed by the cytochrome P450 monooxygenase braC (PubMed:32936132).  In the first round braC hydroxylates C-12 forming brasilane D, which serves as substrate in the second round to establish the epoxide at the bond between C-5 and C-10 and oxidize the alcohol at C-12 to an aldehyde leading to the final product brasilane E (PubMed:32936132).  BraB is also able to glycosylate geraniol, linalool, perillyl alcohol, 3,4-dichlorophenol and, to a lesser extend, benzyl alcohol (PubMed:32936132).
What are the official names of this protein?
O-glycosyltransferase braB, Brasilane terpene glycosides biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the afumC glycosyltransferase family.
Protein: NADK_PSEPG
Sequence: MEQFRNIGIIGRLGSSQVLDTIRRLKKFLLDRHLHVILEDTIAEVLPGHGLQTSTRKLLGEVCDLVIVVGGDGSLLGAARALARHNIPVLGINRGNLGFLTDIRPDELEEKVAQVLDGHYLVENRFLLQAEVRRHHEAIGQGDALNDVVLHPGKSTRMIEFEIYIDGQFVCSQKADGLIVATPTGSTAYALSAGGPIMHPKLDAIVIVPMYPHTLSGRPIVVDGNSELKIVVSKDLQIYPQVSCDGQNHFTCAPGDTITVSKKPQKLRLIHPLDHNYYEVCRTKLGWGSRLGSRDD
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF2_METAC
Sequence: MGRRKKMVERVTTLMNDPQRIRNIGIVAHIDHGKTTLSDNLLAGAGMISKELAGKQLFMDSDEEEQARGITIDSSNVSMVHTFDNEDYLINLIDTPGHVDFGGDVTRAMRAVDGAVVVVDAVEGTMPQTETVLRQALREHVRPVLFVNKVDRLINELQVDSQEMQIRLGKVIDHVNKLIKNMNPEKFKAGWKVDAAAGTVAFGSALYNWAISVPMMKKTGVSFKDVYDYCKAGDMKSLAEKCPLHEAVLDMVIHFLPNPIEAQKGRVKVIWHGDENTEIGKAMTHANAEGDLAFMVTDISVDPHAGEVATGRLFSGSLTRGMEVFTSGSARKSRVQQVGIFMGPERLEVDKIPAGNIAAVTGLKEAIVGSTVTTLDGMTPFESIRHVSEPVVTVAVEAKHTKDLPKLIEVLRQVAKEDPTLQITLDEETGEHLMAGMGELHLEVIAHRIERDKNVEITTSKPIVVYRETIKKKTEPIEGKSPNRHNRFYIYAEPLDTEIVSAIKEGEVSMNLPELERRQKLIDLGMEKEEAKGIVGIFNSNIFIDMTKGIQYLNETMELVLDGFEEVMRAGPLTREPVANVKCVLVDAKLHEDAIHRGPAQIIPAARQAIQAGMLMAEDSLLEPYQKVFVQVPQLLMGGATKELQGRRGIILNMTTEGDLAIIEARVPVAEMFGFAGEIRSATEGRAMWSTEFGGFDVVPSSILNDIVGQIRERKGLKKELPKASDFLSM
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor 2, EF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDB4V_CHATY
Sequence: MKTQTALFSFFLVLLLVATQTEGGILDAITGLLGKRALRNQNFVDYAFDPSLSAADWRALETLLEEY
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Peptide Ctry2606.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted.
Protein: GHRA_ECOLI
Sequence: MDIIFYHPTFDTQWWIEALRKAIPQARVRAWKSGDNDSADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLNPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHREDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESPLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGERVCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.  Inactive towards 2-oxo-D-gluconate, 2-oxoglutarate, oxaloacetate and pyruvate.  Only D- and L-glycerate are involved in the oxidative activity with NADP.  Activity with NAD is very low.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_SYNP2
Sequence: MQDQQQVIHKAQPWHGKVGLIYGQRQGKTEMQRCFTQAPFRIQRPFYPEGNRVCHTVLLHTAGGIVGGDRLSLDLELKPESHVFLTTAAANKIYRTNGETAQQDGIIHQAPGSILEYFPQEMIIFDGAEYHQSLRVNLAPGAVWCGWEVLRFGRTARGEKFISGNWRGLTEIWQDDELLWGDRQWLPGHPEVFAAWNGLNNQPVVGSLALVGLEISEAQMAELRQTMATIQQGLGGITQLPKGVLCRYRGPSSTEVKRWFISLWQNWRSLYSPQPPTLSRVWQTY
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL37_PYRAB
Sequence: MSSGTPSLGKRNKTPTHIRCRRCGRKAFNVKKGYCAACGFGRSRRLRKYRWSKKWKKKKNVH
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L37e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL37 family.
Protein: PRS58_HUMAN
Sequence: MKFILLWALLNLTVALAFNPDYTVSSTPPYLVYLKSDYLPCAGVLIHPLWVITAAHCNLPKLRVILGVTIPADSNEKHLQVIGYEKMIHHPHFSVTSIDHDIMLIKLKTEAELNDYVKLANLPYQTISENTMCSVSTWSYNVCDIYKEPDSLQTVNISVISKPQCRDAYKTYNITENMLCVGIVPGRRQPCKEVSAAPAICNGMLQGILSFADGCVLRADVGIYAKIFYYIPWIENVIQNN
What are the official names of this protein?
Serine protease 58, Trypsin-X3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZN582_HUMAN
Sequence: MSLGSELFRDVAIVFSQEEWQWLAPAQRDLYRDVMLETYSNLVSLGLAVSKPDVISFLEQGKEPWMVERVVSGGLCPVLESRYDTKELFPKQHVYEVESPQWEIMESLTSYGLECSSFQDDWECRNQFDRQQGNPDRHFHQMIIRHEEMPTFDQHASLTFYQKIHTREKPFGYNKCRKDFWQKELLINHQGIYTNEKPYKCKECGKAFKYGSRLIQHENIHSGKKPYECKECGKAFNSGSNFIQHQRVHTGEKPYECKDCEKAFSRSSQLIEHQRTHTGEKPYQCKECGKAFNRISHLKVHYRIHTGEKPYACKECGKTFSHRSQLIQHQTVHTGRKLYECKECGKAFNQGSTLIRHQRIHTGEKPYECKVCGKAFRVSSQLKQHQRIHTGEKPYQCKVCGRAFKRVSHLTVHYRIHTGEKPYECKECGKAFSHCSQLIHHQVIHTEKKPYEYKECEKTLSHDSTTVQPQRMHNRETHVNIINVEKPSISSYPLLIIREFMLASNHMNGSNGESPLA
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 582.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NSP1_ROTHC
Sequence: MANSFREMLYWYRKIIDRKLPCVNVNIWRREIAYKANGICLNCLNECKVCPCDYCGIRHKCENCLNSDCFMNTNNEFNSHRWITFDEEPSQMVLFEYWIMYKDYFLSKFNYNYKAQLKILNMNKNRRFHINESKKKALSVPITSQYLKFKFNNKIYIMFGTFLTSKIQPWIQLKSLKVGYIQSLNVDRCAKLIATKGMFATNSFKSSCITEINARRPISECDYLIEACLCNENNEWKFSAVMGRDKIPVTKSLAMKYFCKNINTELFYYGHSKCHVVSECPRWNQQLRVLNASTLNIIFRRQFMNEVVEWFENFTQLTGMHYDFIKTCVYNKVIISHFRKEIEDYINSGKKISLSSVIPDGHALYTNIDILRISLMLAIDVALNRIESQQMDVL
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: THIC_XANCB
Sequence: MNAAPTVLLQQTQTLSAAVTQPIPGSRKIFVQGSRADLQVPMREIVLTRTPTLFGGQDNPPLSVYDTSGPYTDPQAAIDLAAGLAPLRADWIAERGDTLPLEALSSSFGRGREHDARLDAVRFPSRRLPRVARSGANVTQMHYARRGIITPEMEFVAIRENQRLEAVTDAVLRKQHPGEAFGAAIQQRITPEFVREEIARGRAILPNNINHPESEPMIIGRNFLTKINANIGNSAVSSGIAEEVEKLVWSIRWGGDTVMDLSTGKHIHETRDWIIRNSPVPIGTVPIYQALEKVDGRAEELTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTARRVTGIVSRGGSILAKWCLAHHKENFLYTHFEDICEIMKAYDVAFSLGDGLRPGCIADANDAAQFGELETLGELTKLAWKHDVQTMIEGPGHVPMQLIKENMDKQLRECGEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPNRQDVRDGIMAYKIAAHAADLAKGHPGVQVRDNALSKARFEFRWDDQFHLGLDPEKAKEFHDETLPKDAHKLAHFCSMCGPHFCSMKITQDVRDYAAEHGISEDHALEAGMQEKSGEFVAQGAQVYRAS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: SMC_AQUAE
Sequence: MEKRAYIEKIVVEGFKSYGTKRKEIPLGEGFIAVVGPNGAGKSNIGDAISFALGLSSAKALRAKNLSYLIFSKNGQKADHAYVEVHFKNLGAFPVEDEEVVISRKVSKDGRSIFKINGQVVRERDLKDFLAKAGIYETAYNVVYQGDIVKFLKMTPVERRKIIEEISGIGEYERKKEKALEELAEVELKIKEIDLILEEISNQLKRLKEEKEKLEKFKELQRIKRETEAKILLKEKEKLLKERERILNELSSLRESLEDITFQIQENEKELNERERLLKEVNEKIMPFKEKVGKFTAEIENAERSIKEKERELKESENRVKNLEELINNLLSDKENLEREVGTLQLELEKLKEEYKSLKEVEREKLRELEEEEERLKITFDEVKKLEEEKEKLTEKLNSLNKEKQELEIQRANLKNKIERIKEDINKLISEREEKIKEIKEKEQEIKRLKAIKKKEEEELRNLTQELNIYEKRLSEVRKKLEEVLKEKGAIEREVRSFSDVSDVFKDIKGVYGSVSELIRVKNPEHITAIEVAGGGRLKFIVVEDEEVAKECIQLAKRMNLGRFSFIPLNRVRVEERPLRYPRTKGAVDFAVNLVEYDPKFEKVVKFVFGDTLIVENFESAKAIGIGNYRMVTLEGELFEKSGVITGGAVKPSGELNKRYYEEELQRLNAEEEKLKNEESIIQKKIREIRNLISEKTALLKVSERKIEELSSEGLEQYEEKFKEKLENSKEYLKILEEKLLNVEDKLKELAEEIEYYEEKLNNLKLKEGDIKRHYSREGVEEKRREYSKVRKQVSEIEKSLNEIERELNKKTYELEYLEKEIQEKEREREYLTERIKSLKKEIENLILFKEKTLQEVKEAEVKVYDYIKQKEELEKEILNLKSKLGKLKIKEEELKEKIFEKEKNLKVLEEKIENLNEELKEYEDLKLGADEESIPKLKEKLKRVTEEIQKLGSVNFRAEEDYAEELKRFNDYKEKQQKLKEESKAIKKLIEETENKKRKVFLEAFNQINKSLKRIFSFLSPGGKAQMFLDNPEDPFSGGVQLTVKPRGKDVQYLEAMSGGEKTLAALSLIFALQEYKPSPFYYFDEVDAHLDEVNAKKVGELIREKSKEAQFIVVTLREVVTSFADKIVGVSARGGISEVFFLKNEGLEEIIKEA
What is the function of this protein?
Required for chromosome condensation and partitioning.
What are the official names of this protein?
Chromosome partition protein Smc.
What is the protein family that this protein belongs to?
Belongs to the SMC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINE_SYNS3
Sequence: MTLRDLVDKLLGRQPASASTARDRLQLVLAHDRSDLSPELLDQMRREIFEVVAKYVDIDLEEGDVSLETEDRVTALVANLPFRRPITSAPPKSD
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: SACB5_NEIMD
Sequence: MFILNNRKWRKLKRDPSAFFRDSKFNFLRYFSAKKFAKNFKNSSHIHKTNISKAQSNISSTLKQNRKQDMLIPINFFNFEYIVKELNNQNAIGVYILPSNLTLKPALCILESHKEDFLNKFLLTISSENLKLQYKFNGQIKNPKSVNEIWTDLFSIAHVDMKLSTDRTLSSSISQFWFRLEFCKEDKDFILFPTANRYSRKLWKHSIKNNQLFKEGIRNYSEISSLPYEEDHNFDIDLVFTWVNSEDKNWQELYKKYKPDFNSDATSTSRFLSRDELKFALRSWEMNGSFIRKIFIVSNCAPPAWLDLNNPKIQWVYHEEIMPQSALPTFSSHAIETSLHHIPGISNYFIYSNDDFLLTKPLNKDNFFYSNGIAKLRLEAWGNVNGECTEGEPDYLNGARNANTLLEKEFKKFTTKLHTHSPQSMRTDILFEMEKKYPEEFNRTLHNKFRSLDDIAVTGYLYHHYALLSGRALQSSDKTELVQQNHDFKKKLNNVVTLTKERNFDKLPLSVCINDGADSHLNEEWNVQVIKFLETLFPLPSSFEK
What is the function of this protein?
May be the polymerase that links individual UDP-N-acetyl-D-mannosamine monomers.  In serotype A the capsule is composed of repeated units of (alpha 1-6)-linked N-acetyl-D-mannosamine-1-phosphate (By similarity).
What are the official names of this protein?
Capsular polysaccharide phosphotransferase SacB, Stealth protein SacB.
What is the protein family that this protein belongs to?
Belongs to the stealth family.
Protein: DEOC_PYRNV
Sequence: MLHLVDYALLKPYLTLEEVARGARRAEELGVAAYCVNPLYAPYVRELLSRVKLCVVADFPFGAMPTAARAALVARIAEYAEEIDVVAPIGLVKSHMWGEVRRDLLSVVGAAGGRVVKVIVEEPYLTDEERHRLYDIVAESGAHFIKSSTGFAEEAYARQLGNPTYSTPERAAAIARYIRERGFRLGVKMAGGIRTAEQAKAIIDAIGFGTDPTKVRLGTSTPEALRTLG
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.