PharMolix/UniProtQA huggingface dataset:
Protein: RS11_MESHJ
Sequence: MATNVKKVKKLRPKNVTVGIAHIHSSHQNTIISFTDKQGNVISWASSGSVGFKGTKKKTAYAATLATAAAAQKAREHGIREVIVELKGTGQGKEAARKQIITSGLNILLTKDVTPVPHNGTRPPRKWFKRQEKR
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: PLA5_ORYSI
Sequence: MDKSQGVLLSSNVGAGSRPWPELLGSAHWDGLLDPLDLTLRRLILLCGDLCQVTYDSFNSDSHSRYCGSCRFSRATLLDRTQFPAAGDLSVAAYLYATSDATAFPGSMVYSMSREAWSKESNWIGYVAVSNDAAAAASGQRVIYVAWRGTIRSLEWVDVLKPDLVDHDDILPEGHPGRGRSRVMKGWYLIYSSTDERSPFSKYSARDQMLAAVRELVARYRNESLSVVCTGHSLGASLATLCAFDIVVNGVSKVGDGAHIPVTAVVFGSPQIGNPEFKKQFEEQPNLRALHVRNTPDLIPLYPSGLLGYANVGKTLQVDSKKSPYVKRDTSPGDYHNLQGILHTVAGWDGKDGEFKLQVKRSVALVNKSSGFLKDSNLVPESWWVERNKGMVLGQNGEWQLEGPAEENLPVPPVVTGKIIDDDVAAVATSSSAKEGKKTGKGSKLLSGLIDQLLCVPDTCKAGAA
What is the function of this protein?
Acylhydrolase that catalyzes the hydrolysis of phospholipids at the sn-1 position.
What are the official names of this protein?
Phospholipase A1-II 5.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC1_WHEAT
Sequence: MIDQYKHQQLQIGLVSPQQIKAWANKNLPNGEVVGEVTRPSTFHYKTDKPEKDGLFCERIFGPIKSGICACGNSRASGAENEDERFCQKCGVEFVDSRIRRYQMGYIKLACPVTHVWYLKGLPSYIANLLDKPLKKLEGLVYGDFSFARPSTKKPTFLRLRGLFEEEIASCNHSISPFFSTPGFATFRNREIATGAGAIREQLADLDLRIIIENSLVEWKELEDEGYSGDEWEDRKRRIRKVFLIRRMQLAKHFIQTNVEPEWMVLCLLPVLPPELRPIVYRSGDKVVTSDINELYKRVIRRNNNLAYLLKRSELAPADLVMCQEKLVQEAVDTLLDSGSRGQPTRDGHNKVYKSLSDVIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHQCGLPLEIAIKLFQLFVIRDLITKRATSNVRIAKRKIWEKEPIVWEILQEVMRGHPVLLNRAPTLHRLGIQAFQPTLVEGRTISLHPLVCKGFNADFDGDQMAVHLPLSLEAQAEARLLMFSHMNLLSPAIGDPICVPTQDMLIGLYVLTIGKRRGICANRYNSCRNYPNLKVNYNNNNNSKYRKDKEPHFSSSYDALGAYRQKLISLDSPLWLRWNLDQRVIGSREVPIEVQYESLGTYHEIYAHYLIMGNRKKEIRSIYIRTTLGHISFYREIEEAIQGFSQAYSYTT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DX39B_CANLF
Sequence: MAENDVDNELLDYEEDEVETAAGGDGSEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR
What is the function of this protein?
Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint.  Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity.  Even with the stimulation of RNA, the ATPase activity is weak.  Can only hydrolyze ATP but not other NTPs.  The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA.  However, ssRNA stimulates the ATPase activity much more strongly than dsRNA.  Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro.  The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [] reporting a stimulatory effect.
What are the official names of this protein?
Spliceosome RNA helicase DDX39B, 56 kDa U2AF65-associated protein, DEAD box protein UAP56.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1.
Protein: AROA_ECO55
Sequence: MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQAA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAT_ACIAN
Sequence: MEKKITGYTTVDISQWHRKEHFEAFQSVAQCTYNQTVQLDITAFLKTVKKNKHKFYPAFIHILARLMNAHPEFRMAMKDGELVIWDSVHPCYTVFHEQTETFSSLWSEYHDDFRQFLHIYSQDVACYGENLAYFPKGFIENMFFVSANPWVSFTSFDLNVANMDNFFAPVFTMGKYYTQGDKVLMPLAIQVHHAVCDGFHVGRMLNELQQYCDEWQGGA
What is the function of this protein?
This enzyme is an effector of chloramphenicol resistance in bacteria.
What are the official names of this protein?
Chloramphenicol acetyltransferase, CAT.
What is the protein family that this protein belongs to?
Belongs to the chloramphenicol acetyltransferase family.
Protein: APAG_SALNS
Sequence: MINSPRVCIQVQSVYIEAQSSPDDERYVFAYTVTIRNLGRAPVQLLGRYWLITNGHGRETEVQGEGVVGVQPRIAPGEEYQYTSGAVIETPLGTMQGHYEMIDENGDAFTIDIPVFRLAVPTLIH
What are the official names of this protein?
Protein ApaG.
Protein: RL13E_SULIM
Sequence: MEFPKALIKRPNYHFEYPHKRKDKRIGRGFSIGELEKAGLNINNARKLGIIVDIRRKSVHEENVEVLKKFLEQLSNQKS
What are the official names of this protein?
50S ribosomal protein L13e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL13 family.
Protein: BIOD_BAUCH
Sequence: MTKRYFITGTDTNVGKTLAACALLQAAISIGYHAAGYKPVATGYQLTLDGPRNNDALALLSNSNVILSYSQVNPLVFSEPTSPHIACRAEGRNIELSELSAGLKVIEQKSDWIVVEGAGGWFTPLGEGILYSDWVNYEKLPVILVIGMKLGCINHALLTALAIRQFGLQLVGWIANHIQPTTTWSQHYLAELRNRLDAPLIGDIPWLSNIPVALLAKYINLAELS
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YRBL_SHIFL
Sequence: MIRLSEQSPLGTGRHRKCYAHPEDAQRCIKIVYHRGDGGDKEIRRELKYYAHLGRRLKDWSGIPRYHGTVETDCGTGYVYDVIADFDGKPSITLTEFAEQCRYEEDIAQLRQLLKQLKRYLQDNRIVTMSLKPQNILCHRISESEVIPVVCDNIGESTLIPLATWSKWCCLRKQERLWKRFIAQPALAIALQKDLQPRESKTLALTSREA
What are the official names of this protein?
Uncharacterized protein YrbL.
Protein: GLMU_XANCP
Sequence: MTLPLHVVILAAGEGKRMRSALPKVLQPLAGQPMLAHVIATARELQPAAIHVVHGHGGAQVQAAFAGQPDLQWAEQRQQLGTGHAVQQALHAVPDAATVLVLYGDVPLIRSESLRELLHAPGRIAVLVADLANPSGYGRIVRNPEGKVAAIVEQKDADDEQRRIRTINTGILTAESTALRRWLGGLSNDNAQGEFYLTDVFASAAADYTPADMVQVSDPQDVEGANDPWQLAQLERAWQLRAARALCLQGVRMADPARVEQRGRVQVGHDVQLDIDVILEGEVTLGDGVVIGPFVRLRDVQLAAGTQVRAHCDLEGVVTEGAVQIGPFARLRPGTVLADGVHIGNFVETKKVVMGAGSKANHLTYLGDAVVGSKVNIGAGTITCNYDGVNKSQTTIGDGAFVGSNSALVAPIEIGTGATIGAGSVITRDAPPHQLSVARPRQTVIEGWERPKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DI192_ARATH
Sequence: MEDDMWCVSSSGSSRSYRSETAAKYQSGPYQDLEEFEEVDDDIAVEYPCPFCASDYDLVELCHHIDEEHRHEANNGICPVCSKRVKMHMVDHITSHHRDVLKSEQKEMSYREDPYLSDKYLQPHLDELPPSMNHHQHPSKHVSDQFLSFINNSALPNQTKLVLPDSSVEDKNPIKDSSAAKEGTSSCPLSDSDKLEKAKKCEFVQGLLSSAMFDDECDSSE
What are the official names of this protein?
Protein DEHYDRATION-INDUCED 19 homolog 2, AtDi19-2.
What is the protein family that this protein belongs to?
Belongs to the Di19 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RTCB_XENTR
Sequence: MSRSYNDELQYLDKIHKNCWRIRKGFVPNMQVEGVFYVNDPLEKLMFEELRNASRGGAAGGFLPAMKQIGNVAALPGIIHRSIGLPDVHSGYGFAIGNMAAFDMDNPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMGAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPSKVSSKAKKRGLPQLGTLGAGNHYAEVQVVDDIYDEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVAMEKAMKRDKITVNDRQLACARISSAEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFSKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKEKTLLVHRKGSTRAFPPHHPLIPVDYQLTGQPVLIGGTMGTCSYVLTGTDQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADLGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG
What is the function of this protein?
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.  May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
What are the official names of this protein?
RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: UREE_ACIBY
Sequence: MKIYTQRLEDISPDQAFETVELTFDTRQKSRFRAALASGVDIGADLPRTGILRSGSYIATQEGDVLRVDAKPERLMKVTAQTEFDLLKAAYHLGNRHVPLMLTPTALYFEPDHVLAEMVEGLGLTVTETDHPFEPESGAYAQHSHDHRLSPIKALHHVHS
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_PSEPG
Sequence: MTDQTTRLPVRRALISVSDKTGILEFARELQQLGVEILSTGGTYKLLKDNGVNAVEVADYTGFAEMMDGRVKTLHPKIHGGILGRRGTDDAIMNEHGIKPIDLVAVNLYPFEATISKPGCDLPTAIENIDIGGPTMVRSAAKNHKDVAIVVNASDYAGIVEGLKVGGLTYAQRFDLMLKAFEHTAAYDGMIANYMGTIDQAKDTLSTADRSEFPRTFNSQFVKAQEMRYGENPHQSAAFYVEAKKGEASISTAIQLQGKELSFNNVADTDAALECVKSFVKPACVIVKHANPCGVAVVPEEEGGIRKAYDLAYATDTESAFGGIIAFNRELDGETAKAIVDRQFVEVIIAPKISQAARDVVAAKQNVRLLECGEWPAERAAGWDFKRVNGGLLVQSRDIGMITADDLKIVTKRAPTEQEIHDLVFAWKVAKFVKSNAIVYAKQRQTIGVGAGQMSRVNSARIAAIKAEHAGLQVQGAVMASDAFFPFRDGIDNAAKVGISAVIQPGGSMRDAEVIAAADEAGIAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: RUVA_STAHJ
Sequence: MYAYIRGKLTQLFPTHVVVESINGVGYEIQTPNSYRFQKYLEKELVIYTSLIVREDAQLLYGFINEEEKDMFLSLIKVTGIGPKSALAILATSTPNEVKMAIENENDAYLTKFPGIGKKTARQIVLDLKGKVQITRETTETLLSMNEENSNSENLVKEALLALEALGYSKREISKVEKVLNKSTFDSVDEAVKLGLKTLVS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: VIUB_VIBC3
Sequence: MSNEVERVYPRLLDFVRKKYVSKNLLRVTLTGEDLIGFPEDQNGSHIKVFFPNQASGILQLPIREGDKVIWPEHKPVPRAYTVRQYRAQSNELDIDFVVHGEGTPGGGWALKAQTGSQLGLIGPGGPDPLIEPADWHIMAGDLSAVPAISAILEKMPSQAKGYVFLEVDDIEDKHDISHPEQMVIKWLVRDPNQAQPVLAMAIEQLPVPQGAESLSAFVAGENESVIACRKILRNEYRIARDKIYAIPYWKRGKNEEAYHEERHVVMDEEF
What is the function of this protein?
Involved in intracellular removal of iron from iron-vibriobactin complex.  Vibriobactin is an iron-chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm.
What are the official names of this protein?
Vibriobactin utilization protein ViuB.
What is the protein family that this protein belongs to?
Belongs to the SIP oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRIF1_RAT
Sequence: MSNRLQTVFLKTAEEKSGSHCISGCMYQVVPTIGTDGKKLLQLLPIPKSSGNLIPVVQSPVMSHGLKGNTEKPVQVTFQTQISSSSTSASVQLPVLQPANTTKYFLTGTIDTSGKDRVTSMGTGNFTPPISNTQNHGVKIHRLTRQTFTIPPSTQNDSSYFIVNTPSLPANVNSSTLPSGPPLTIPAHAEVKPVLASPLPPLVQQKILGTVTTSTSGTVEASQIPAVFYVSPVNSVKIIVDKKTQNIYHKPVTFSTSQIPPNVATKTQLNSGQHPQAAPVNLIFQEYLQPGIPCLVPVKSSNNVPSKVFNTFVDRKTLGDNTVGTPLLSTNSSSRTQSISVPIKDDGLIMFNGKVLLNKKGTYGLPSKIDQQNSVSSDIPLKDSSQVVSSSLVTEISREVLSSVLVKSKSFQLKTKSLSNSQPAPMAHIKPEKSEKVERPSFSVTSPHTTNQSTHCLKQSKIVFINPVFSDGFRTGQNTPRKENLIQNIRSSVDAATVTSQQCVFRDQEPQTQYEMASILKKDIQERSNKKYSQGNHTKASYLKNDAEFKKIFGLTKDLRVCLTRIPDHLSSTKSFDSFNNLKSSSYKDANVVMKEEKKQSFSKKRNAKPMKKMDYTKRRKIENASDMVMNVMNGTDVANSQLLSSILPISDIAQHNIITSHSTTREDKRTETEHCCHEKQEKGTLSSSTSFEQSNYFNKNYTEDIFPVTPPELEETIRDEKIRRLKQILREKEAALEELRKKMHQKQ
What is the function of this protein?
Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin.  Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases.
What are the official names of this protein?
Ligand-dependent nuclear receptor-interacting factor 1.
What is the protein family that this protein belongs to?
Belongs to the LRIF1 family.
What are the subcellular locations of this protein?
Chromosome. Nucleus matrix. Note=Localizes to Barr body; recruited by SMCHD1.
Protein: GLPE_PSEPK
Sequence: MSEFKRIPPEQALELRKKEGAVVVDIRDPQAFAAGHITGARHLDNHSVADFIRNADLDAPTLVVCYHGNSSQSAAAYLVGQGFSDVYSVDGGFELWRATYPAETAQGNAE
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEAF1_HUMAN
Sequence: MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEASVQPPCRASHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPPTPTKAAPPALVNGLELSEPRSWLYLEEMVNSLLNTAQQLKTLFEQAKHASTYREAATNQAKIHADAERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHICGQSAAVTVQADEVHVAESVMEKVTV
What is the function of this protein?
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene.  Down-regulates transcription of these genes.  Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'.  Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction.  When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.  Required for neural tube closure and skeletal patterning.  Regulates epithelial cell proliferation and side-branching in the mammary gland.  Controls the expression of peripheral tissue antigens in pancreatic lymph nodes.  Isoform 1 displays greater transcriptional activity than isoform 4.  Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.  Transcriptional activator of EIF4G3.
What are the official names of this protein?
Deformed epidermal autoregulatory factor 1 homolog, Nuclear DEAF-1-related transcriptional regulator, NUDR, Suppressin, Zinc finger MYND domain-containing protein 5.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus. Cytoplasm. Note=Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270%. SUBCELLULAR LOCATION: [Isoform 2]: Secreted. Note=Secreted in some cell types. SUBCELLULAR LOCATION: [Isoform 3]: Secreted. Note=Secreted in some cell types. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. Note=When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced.
Protein: EIF3E_PONAB
Sequence: MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.  Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway.  May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit E, eIF3e, Eukaryotic translation initiation factor 3 subunit 6, eIF-3 p48.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit E family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, PML body.
Protein: ARCH_SULIM
Sequence: MRSFEFFEHTADVGIRAYGKSLEEAFSNAALGVFEVITDTSKVKPIEYREIYLNGYDLENLLYKWIEELLYYYDSELMVFSKFDLMIDQDSMTLEGKAWGEKFNGKIHERRTVVKAMTYHQLSIEKTENGYVITFVVDI
What is the function of this protein?
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB.  Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation.  Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
What are the official names of this protein?
Protein archease.
What is the protein family that this protein belongs to?
Belongs to the archease family.
Protein: EV467_RHIPC
Sequence: MALKACITVIAVVYVVQVVRGAEKSLDSDSSGEDYELWTQGCPFLVAENRTGFGTTVSCQHNCNGAIEKVPEGEPCYTIGEDGLGRMKLNLPYNCSLGECSGGVCVPNGRSDVCFKRTWEENNKAMA
What is the function of this protein?
Salivary chemokine-binding protein which binds to host chemokines CCL1, CCL2, CCL3 and CCL5.
What are the official names of this protein?
Evasin P467.
What are the subcellular locations of this protein?
Secreted.
Protein: TM248_BOVIN
Sequence: MFNINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTAAPESTVTSGQARTSTQSPQPLEDAGPVNISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAQEEINITFTLPTSWSSDDCALHGHCEQVVFTACMTLTAHPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALADA
What are the official names of this protein?
Transmembrane protein 248.
What is the protein family that this protein belongs to?
Belongs to the TMEM248 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PYRB_CHLPD
Sequence: MKHLTGLCELPLYEIQRLLDLAAVFKKELRTKAPAFAPTLLSKKIALAFFENSTRTRFSFEIAAKHLGASTLNFTASSSSVSKGETLGDTIKNLEAMQVDAFVIRHPSSGAADLITGITSKSVINAGDGSHEHPTQALLDMFTLKEHFGSLEGLNVFILGDILHSRVARSNIFGMLTLGANVALCSPSTLLPPGTSDLGIRIFTDLDQAIQWADAAIVLRLQLERATGGYLPSLGEYAVHFGLTDERLERIRKHLLVLHPGPINREIEISSRVADRMQPPGFSSSLLLQQVTNGIAVRMAVLQTLLAE
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL11_PYRHO
Sequence: MKKQVVEVLVEGGKATPGPPLGPAIGPLGLNVKQVVDKINEATKEFAGMQVPVKIIVDPVTKQFEIEVGVPPTSQLIKKELGLEKGSGEPKHNIVGNLTMEQVIKIAKMKRSQMLALTLKAAAKEVIGTALSMGVTVEGKDPRIVQREIDEGVYDELFEKAEKE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CENPX_YEAST
Sequence: MLSKEALIKILSQNEGGNDMKIADEVVPMIQKYLDIFIDEAVLRSLQSHKDINGERGDKSPLELSHQDLERIVGLLLMDM
What is the function of this protein?
DNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance (PubMed:20347428).  FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (By similarity).  Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis.  Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:22561346).
What are the official names of this protein?
Inner kinetochore subunit MHF2, CENP-X homolog, Constitutive centromere-associated network protein MHF2, MHF histone-fold complex subunit 2, MPH1-associated histone-fold protein 2.
What is the protein family that this protein belongs to?
Belongs to the CENP-X/MHF2 family.