PharMolix/UniProtQA huggingface dataset:
Protein: NUOK_SORC5
Sequence: MISVPIEYYLVVAAVLFLIGSIGFLLRRNLLVLLMSIELMLNAVNLTLVAYNRVHPHDHAGQIFTFFVIAIAAAEAAVGLAIVLAFYRIRKTMRSDDADLLRS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOZ_METS4
Sequence: MARVTVEDCIDKVENRFELVLLAGHRARLLSSGAPLTVDRDRDKNPVVALREIADETITPDDLKEQLIHSLQKYVEVDEPEPEAVPLLSSSPAAAAVAPQAASGDDNDIQFDRMSEEDLLRGLENLAPPTETEDEGD
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PROA_CAUVC
Sequence: MAGMGRTAREGARALRLATPEQRTAAIQAMAVAIREDADAILTANAKDLARAEANGVSGPMLDRLALDAARLEGVAAGVEAVAAVPDPVGVATSRWTRPNGLDIARVRTPIGVIAMIYESRPNVTADAAALCVRSGNAVILRGGSECIHSNLAIHAAIARGLQKAGLPTAAVQAVKTPDRAAVGMILAGLDRTIDLIIPRGGKSLVARVQAEARAPVLGHLEGLNHVFVHAAADLKKAVEVVVNAKLRRVSVCGSAETLLIDQAAADKLLPPIADALIKAGCELRGDAAARAIEPTMKKATVEDWTTEYLAPILSVAVVDGVAGAARHIASYGSGHTDAIITEDAAAAEAFIAEVDSAIVLVNASTQFADGGEFGFGAEIGIATDKLHARGPVGAEQLTTFKYVVRGTGQTRP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_IGNH4
Sequence: MKIKIAARGSKLSLKQVSMFTSYLLKFFPDLEYEVITVKTTGDKANAPFEELAKRGLTGLFEKEVNKAVLEGKADVAVHSLKDLPTELDPRLEIAAFLPRDPPYDVLISRAGNYDIFDLPKGSVVGTSSARRKALIKNLRPDLVVKDLRGNVDTRLEKLRRGEYDAIVLAEAGVSRLGLNVDYVRLDWRLFPPSPGQGIIVAVTRKGSEISDLLKSISDVKSEKLATAERTVLKEFGGGCFVALGAIAFEEGSLIRLRATVLSPSGRERVDVELIGKGPEEVGMRAAERLKALNPMKTTVGSEE
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Probable porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: ILVD_BACC2
Sequence: MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGEVVDLSSVFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKQAAEKLKILIERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAQEAGLDYDMNRIDAVSRRVPHLCKVSPASNWHMEDIDRAGGISAILKEISRKEGVLHLDRITATGQTLRENIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHISPEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEAKVKTGWLGRYAQMVTSANTGAVLKIPDFD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RL27_SALPC
Sequence: MAHKKAGGSTRNGRDSEAKRLGVKRFGGEAVLAGSIIVRQRGTKFHAGTNVGCGRDHTLFAKADGKVKFEVKGPKNRKYISIVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PG122_VACCC
Sequence: MNFYRSSIISQIIKYNRRLAKSIICEDDSQIITLTAFVNQCLWCHKRVSVSAILLTTDNKILVCNRRDSFLYSEIIRTRNMFRKKRLFLNYSNYLSKQERSILSSFFSLYPATADNDRIDAIYPGGIPKRGENVPECLSREIKEEVNIDNSFVFIDTRFFIHGIIEDTIINKFFEVIFFVGRISLTSDQIIDTFKSNHEIKDLIFLDPNSGNGLQYEIAKYALDTAKLKCYGHRGCYYESLKKLTEDD
What is the function of this protein?
Decapping enzyme that remove the protective 5'-cap from both host and viral mRNAs to commit transcripts for decay by the cellular exonuclease XRN1.  Preferentially targets spliced mRNAs and since all viral genes are intronless, it preferentially targets host over viral transcripts.  Acceleration of the turnover of cellular transcripts promotes the shutoff of host protein synthesis and therefore diminish the magnitude of antiviral response.
What are the official names of this protein?
mRNA-decapping protein OPG122.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: KPRS_BAUCH
Sequence: MKLFAGNAIPELAQLIANRLYTSLGVAAVNRFSDGEISVQINENVRGGDLFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVMPYFGYSRQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQQDFNNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANMSQVMHIIGEVADRDCVLVDDMIDTSSTLCKAAEALKEHGAKRVFAYATHPIFSGQAHANIKNSVIDEVIICDTIPLNSAIKALPNVRTLTLSGMLAEAIRRISNEESISAMFEH
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCTA_YERPB
Sequence: MKVSIFKTLYFQVLTAITIGVLLGHFYPEIGAQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAIALLYFEIVSTLALLIGLVVVNVAQPGVGMNIDPATLDAKAVALYAEQASQQGIIPFLLDIIPGSVVGAFASGNILQVLLFAVLFGFALHRLGEKGQLIFNVIESFSRVIFGVINMIMRLAPLGAFGAMAFTIGKYGVGSLVQLGQLILCFYLTCILFVVLVLGTIAKFNGFNIFKFIRYIKEELLIVLGTSSSESVLPRMLDKMENAGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTHMDIMHQVTLLVVLLLSSKGAAGVTGSGFIVLAATISAVGHLPLAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWCKQLDNDQLQAVLSNKVLPNVKSSVSVS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PLET1_MESAU
Sequence: MAVLRSLLPQLGLFLCLALCFSPALSASYNDPCTVFDTISTTNLRVNITAEGSGENITYTVWVHVNSSVSVVILKAVNQDNKPVGTWVGATQECNDSSVLYRVTPSDNSDFQATWIVPNSEDITKVNLHVLMAIGNGTAAVTSVNLGEPQTSTPLRPTPEISETNQTTTMTTDKTPAMTTAKTPAMTTAKTTAKTTAKTTVKTTAMTTAKTTAKSLAVNALGSPLAGALHILLVFLISKLLF
What is the function of this protein?
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair.  May play a role during trichilemmal differentiation of the hair follicle (By similarity).
What are the official names of this protein?
Placenta-expressed transcript 1 protein, Antigen AgK114.
What are the subcellular locations of this protein?
Apical cell membrane; Lipid-anchor, GPI-anchor. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli.
Protein: GSA_HELPS
Sequence: MELLHSINDFNEAKQVIAGGVNSPVRAFKSVKGTPPFILKGKGAYLYDVDNNHYIDFVQSWGPLIFGHADEEIEENIINVLKKGTSFGTPTELETTLAKEIISCYEGLDKVRLVSSGTEATMSAIRLARAYSQKDDLIKFEGCYHGHSDSLLVKAGSGCATFGSPSSLGVPNDFSKHTLVARYNDLNSTEECFKKGDVGCVIIEPIAGNMGLVPAQKEFLLGLKALCEKYQAVLILDEVMSGFRASLSGSQEFYGVVPDLVTFGKVIGAGLPLACFGGRAEIMDLLSPIGGVYQAGTLSGNPLAVCAGLSALYKIKRDKTLYTRLNALAVRLAQGLKKSAQSYNIALETLNRGSMFGFFFNENAVRDFDDALKSDTEMFAKFHQKMLFKGVYLACSSFETGFICEPMTEEMIDLAVAKADESFDEIIKGV
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I54A2
Sequence: MNPNQKIITIGSICMTIGTISLILQIGNIISIWISHSIQTGSQNHTGICNQRIITYENNTWVNQTYVNISNTNVVAGKDTTSMILAGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPIGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDDGAVAVLKYNGIITEIIKSWRKQILRTQESECVCVNGSCFTIMTDGPSDGPASYRIFKIEKGKITKSIELDAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFNQNLDYQIGYICSGVFGDNPRPKDGKGSCDPVNVDGADGVKGFSYRYGDGVWIGRTKSNSSRKGFEMIWDPNGWTDTDDNFLVKQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPREKTTIWTSGSSISFCGVNSDTVNWSWPDGAELPFTIDM
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: KN13B_ARATH
Sequence: MSGRQRSVAAAVHHQRQLSDNPLDMSSSNGRWLQSTGLQHFQSSANDYGYYAGGQGGGGQAARGYQNAQRGNEFFGEPTTPQYGARPTNQRKNNDESEFSPGLLDLHSFDTELLPEIPVSNQLDGPSLFNPSQGQSFDDFEAYNKQPNRSRVLAENLAAEKERMNAVAKIKVVVRKRPLNKKESTKNEEDIVDTHANCLTVHETKLKVDLTAYVEKHEFVFDAVLDEEVSNDEVYRETVEPVVPLIFQRIKATCFAYGQTGSGKTYTMKPLPLKASRDILRLMHHTYRNQGFQLFVSFFEIYGGKLYDLLSERKKLCMREDGKQQVCIVGLQEYRVSDTDAIMELIERGSATRSTGTTGANEESSRSHAILQLAIKKSVEGNQSKPPRLVGKLSFIDLAGSERGADTTDNDKQTRLEGAEINKSLLALKECIRALDNDQGHIPFRGSKLTEVLRDSFMGNSRTVMISCISPSSGSCEHTLNTLRYADRVKSLSKGNASKKDVSSSTMNLRESTKIPLSSALPTPSNFDDDVNEMWTEENDEFDASDYEQDKQMWKKNGKLEPSYNGMAQERIPKPTIQMKSRDMPRPDMKKSNSDDNLNALLQEEEDLVNAHRKQVEDTMNIVKEEMNLLVEADQPGNQLDGYISRLNTILSQKAAGILQLQNRLAHFQKRLREHNVLVSTTGY
What is the function of this protein?
Acts redundantly with KIN13A to modulate cell wall synthesis and cell expansion via the THE1 pathway.
What are the official names of this protein?
Kinesin-like protein KIN-13B, AtKINESIN-13B, AtKIN13B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.
Protein: CBPC5_XENTR
Sequence: MEVRCGGLLFSSKFDSGNLARVEKVEKPGAEGDAFSGSVSGGSVPTPDYEFNIWTKPDCAETEYENGNRSWFYFSVRFGAPGKLIKINIMNMNKQSKLYSQGMAPFVRTVPIRSRWERIRDRPTFEMVENQFILSFVHRFLDCRGSTTYFAFCFPFSYEESQELMAGLDDRFSDCKNITPGSFPDSIYYHRELLCHSLDGLRVDLLTISSCHGMTEEREPRLDKLFPDRSTPRPYRFTGKRVYFLSSRVHPGETPSSFVFNGFLEFILRQDDPRAQMLRRMFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLNPDFELHPSVYAAKTVLLYHHVYNSVGPNDPDWRTSVSLQTSNISLCPKTSNHSLKDLPLEDSLSELEKANNLLNSMEKEECYITCPQAVTQGAPPENDPNFLSDSRDFIRQRDVFILESDTEPKDIYSHSGSSQPTIFTKSIPPQESGIAFYVDLHGHASKRGCFMYGNYFTEENDQVENMLYPKLISLNSANFDFLACNFSEKNMYAKDKRDGQSKEGSGRVAIHKATGIIHSYTLECNYNTGRCVNSIPAACHDCGRASPPPPPAFPPKYTTQVFEQIGRAVATAALDMAECNPWPRLIMSEYNNLTNLRAWMLKHLRNTKGVLPGTLKKKSTKSPVKASSLTSGSLSENSLIRTRSYSNSTASTNSQQNSPQIKPSINFTFLCSSSNHSPPKVSQRVLGPVRETKAQEKRRQQSLLRSSVRSPTACQQRLSTQAPSLSSGYPKTSSHAKTSCPLSLSLSMSGSGFSGLSQAAKVKNGTKKNNLEGDSTRQHIHQGHGIALLQNMQKRGSSHNNAEYSKSLESLGVRPSRIPVRRNGLLTNEKESPILRVWKYTTDTSLKHCSLADLAAVTSSLTVCSVPLLKSKAEEPVFICEATKETADQHFPAVSQDAAHLSAYQSVLSFCSEA
What is the function of this protein?
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins.  Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin.  Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate.  Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin.
What are the official names of this protein?
Cytosolic carboxypeptidase-like protein 5, ATP/GTP-binding protein-like 5, Protein deglutamylase CCP5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
Protein: VE1_HPV28
Sequence: MDDTSGTEGDECSELERAGGWFMVEAIVDRRTGDKPSSDEDEDEDADEGEDFVDFIDDRPVGDGQEVAQELLLQQAAADDDVAVQAVKRKFAPSPYFSPVCMQPSIENELSPRLDAIKLGRQSGTAKRRLFQLPDSGYGQTQVDTESGPLQVQDICETGTQDGRQDADEGSGRNVGGNGGQEEERAGGDGEESQTQGVQTDKAACGVLAILRASNQKATLLGKFKEQFGLGFNELIRHFKSSKTVCLDWVVCVFGVYCTLAEGIKTLIQPQCDYAHIQVLSCQWGMTVLMLVRYKRAKNRETVAKGLSTLLNVPESHMLIEPPKLRSGPAALYWYKTAMSNCSDVYGETPEWIVRQTMVGHALEEAQFSLSEMVQYAYDHDITDESMLAFEYALLADTDANAAAFLSSNCQAKYVKDACTMCRHYKRGEQARMNMSEWIWFRGDKVQGDGDWKPIVQFLRYHDVEFIPFLCAFKTFLQGIPKKSCLVFYGPADTGKSYFCMSLLRFLGGVVISYANSNSHFWLQPLADAKIGLLDDATSQCWCYIDTYLRNALDGNQVCIDRKHRALLQLKCPPLLITTNINPLEDDRWKYLRSRVQLFTFKNKFPLTTQGEPLYTLNDQNWKCFFRRLWARLSLTDPDDEEENGNPSEPFRCVPGQNARTL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ALP6_SCHPO
Sequence: MSEIHVKTALSRLADKYLQNSKNPSVPYTIETIVSFFQEIIHSISPDTFQLDIDDILYKIYSKIPPEENNDALFSKLSNLVSRLKSQTVIHNKSQILYFLYLLSPISQSSRDVSSHLLDESISNPINIPSTEVESSNFGQTRYDQVPENPQITDWDEGLENESSISIAHDSSRLNRSTETSSVQHTLITEADLLSSISYVLQGISTEYVQFKNELALLSKRIPVQYLLQMRALSETGLLYQELKVFSNYDPSVSQSIDGDNVSKAFINDQSLALQSLKSVISKELTNFLALIASLDSQIRADASLEKPMVTIRRCIAWTQVAKLKLRILSSVVNDNMNQENKKRLIQVVSKYNVHGDPLIQELSDKILTEITGPLYEMIENWIYKGELVDPYQEFFVKEKNGSESHDHQGQGDVVWKGKYFLDKELIPSFLSEELVDKIFLIGKSLNFARYGCGDFDWAQEHYQKLVKKLSYRDPHSLETVVDKAYTESINHLVYLMEEVFHLTDHLKAIKKYLLLGQGDFVDLLMESLGNSLDQPANTLFRHNLTASLESAIRSSNASYEPEYVLKRLDARLLELSHGETGWDVFTLEYKVDSPINVIITPYCSRQYLKIFNFLWRLKRIEFALAHSWRRVNLGERNVFRNLDYTKFEWHFVSCHLAEMIHFVCQLQYYILFEVIEISWQELQLAMEKPNATLDTYIEAHEKYVTSITHKGLLGGGKSRNEDSFLHQLHDILKVILNFHDAIELLYNFSCSLSNRIRINVPISTDALAAQYTPIKNELSNFTEEFQVRLQKLLHGLASHKDPEMRFLSVRLNYNEFYVSHRRRHDKDVTSQ
What is the function of this protein?
Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles.
What are the official names of this protein?
Spindle pole body component alp6, Altered polarity protein 6.
What is the protein family that this protein belongs to?
Belongs to the TUBGCP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localizes to the SPB and also to the equatorial MTOC.
Protein: PIGB_SERS3
Sequence: MIIQRLFGILYMLAGLAKAFPQFENVPAVLRQAAIANQGTWYAAASIWLGAHGDVINILVGVVLFGSGVILMLNPLWTTLVIYAQLLMMAVFVVILHQSQPQVMLLDGVFALAALYMLRGQYHRKPKPRTFPTTSFSLPTPSSESSFSAPLGDEYDVVIIGGGASGLTAASEFTHERVLVLEKSSTFGGNARYHTFNRLKHPTAGVCFQEPFPGSNMLRLLKKIGLEGKYKSNEKDTLVFFDTFLLLKCLGEIVVGFIKQPRYLLKLSVWGLTSQLFLHAIIGKPYVVAAKQLGDPIFADLYTFLDKFSPRGDFYPRLPWTPNGSWSKAHMELLDNISLYTYLFEPDKLGRLPEQLRPPARLGKLVENAVSTTLRVECLDIHDVSAYVGLHFLVGYLRGNLVTLPGGNGSISAGLCKYLSHQRNVTLQNHVQLTAVEPQHNGTCIQFTINGQPRQVQAQQIIWAAPKTQLATWLPGLPAKQLAAIKNIRHEDYYLANVFLSKPVLGHSFGGYMIEPDSNKDPFSWCKAGTCLVANWMDDHADVDVGVLTLLKPTTRSERQDRTAQNAFLALQQQTYAEIAKVLRNIGIGAEVIEDIQIWYWPAGLVTSVVGQQAEGVFETARQSFENIHFANQDSVGVGNIESAILSGIDAANAVKAQLMDTENVVEVAG
What is the function of this protein?
Involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig).  Catalyzes the oxidation of dihydro form of MAP (H2MAP) to yield MAP.
What are the official names of this protein?
Oxidoreductase PigB.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: VIP1_MOUSE
Sequence: MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPEAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDLQREPLAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDSPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNIHMTEEKQGFGLLQETPGDGTRELHIERQQELVEPAQSPQELPVEICPSGSQGVTKVSQTCQEVPDIVQPCHNIHEEIGQPQQEVPDISQLLLKDHDTTTNTCHLCQASQLSQKVCEEICQLCQDNHEESNQLCQEVSVKLGRMVHGFPVNVDSTAQETLMEIGRPTQEIPEDPYQEFSVKVGVLAQKAPAISELSQDIPEADKPSQELSEETELQAQEVSEEIDQESEVVDELPPEAIS
What is the function of this protein?
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4.  PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation.  Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4.  Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.  Activated when cells are exposed to hyperosmotic stress.
What are the official names of this protein?
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1, Diphosphoinositol pentakisphosphate kinase 1, Histidine acid phosphatase domain-containing protein 2A, InsP6 and PP-IP5 kinase 1, VIP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.
Protein: RISB_ECOSE
Sequence: MNIIEANVATPDARVAITIARFNNFINDSLLEGAIDALKRIGQVKDENITVVWVPGAYELPLAAGALAKTGKYDAVIALGTVIRGGTAHFEYVAGGASNGLAHVAQDSEIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVLKAIKA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: RS10_STRMK
Sequence: MADQKIRIRLKAFDHRLIDRSASEIVETAKRTGAQVRGPIPLPTKIERYTVLVSPHVDKDARDQYETRTHKRVLDIVDPNDKTVDALMKLELAAGVDVQIKLT
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.