PharMolix/UniProtQA huggingface dataset:
Protein: SUCB_NEOFR
Sequence: MLANVTRSTSKAAPALASIAQTAQKRFLSVHEYCSMNLLHEYNVNAPKGIVAKTPEEAYQAAKKLNTEDLVIKAQVLAGGRGKGHFDSGLQGGVKLCYTPEQVKDYASKMLGHKLITKQTGAAGRDCNAVYVVERQYAAREYYFAILLDRATRGPVLVASSEGGVEIEEVAKTNPDAILTVPFSIKTGLTREVALDTAKKMGFTEKCVPQAADTFMKLYKIFIEKDATMVEINPMAENNRGEVVCMDAKFGFDDNASYKPKGIFALRDTTQEDPREVAGHAKWNLNYVGMEGNIGCLVNGAGLAMATMDIIKLNGGVPANFLDVGGSATAKQVKEAFKIISSDKAVSAILVNIFGGIMRCDIVAEGVIQAVKELGLDIPLVVRLQGTKVEEARELIKNSNLSLYAIDDLDKAAKKVVQLANVVGLAKENGIKIKIEN
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, hydrogenosomal, Succinyl-CoA synthetase beta chain, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
What are the subcellular locations of this protein?
Hydrogenosome.
Protein: SAHH_HALHL
Sequence: MSNQDYKVADISLADWGRKEIKIAESEMPGLMETRREFAAQKPLKGARIAGCLHMTIQTAVLIETLQELGAEVRWSSCNIFSTQDQAAAAVAANGTPVFAWKGETEEEYWWCIEQTINGPDGWKPNMLLDDGGDLTAVIHEQYPDMMKDIYGVSEETTTGVHRLYEMSRKGELGMPAFNVNDSVTKSKFDNLYGCRESLVDSIKRATDVMIAGKVAVVAGFGDVGKGSAQSLRGLGAQVWVTEVDPICALQASMDGYKVVTMEEAAPVADIFVTATGNYNVITHDHMKAMKDEAIVCNIGHFDNEIDVASLKQYKWDEIKPQVDHVEFPDGKKITLLAEGRLVNLGCATGHPSFVMSNSFTNQVMAQMELYNNPGKYEKDVYVLPKHLDEKVAALHLGRVGANLTRLSEEQAGYIGVSVDGPFKPEWYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_BURCM
Sequence: MKQPSALSALVEALRVLPGVGPKSAQRMAYHLMQHDREGAERLGRSLLFATEHLQHCEKCNTFTEAQICEVCSDDERDPTLLCVVETPADQIMLEQTMTYRGLYFVLMGRLSPLDGIGPKEIHFDRLVRRASDGVVKEVVLATNFTNEGEATAHYLGQTLKARGLAVTRLARGVPVGGELEYVDAGTIARAMLDRRTM
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: NAA20_MOUSE
Sequence: MTTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE
What is the function of this protein?
Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln.  Proteins with cell cycle functions are overrepresented in the pool of NatB substrates.  Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
What are the official names of this protein?
N-alpha-acetyltransferase 20, Methionine N-acetyltransferase, N-acetyltransferase 5, N-terminal acetyltransferase B complex catalytic subunit NAA20, N-terminal acetyltransferase B complex catalytic subunit NAT5, NatB complex subunit NAT5, NatB catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ARD1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MEU31_SCHPO
Sequence: MSCISEIGKFVKSIEYIKLPCLFIFAAIVGMNLSLLYCLLKGWKNVMIWGIETMLFGAIGIFFAWKKKLSWEHLVLLWSTIDAFFSMCLRSCTIIYFSMNPYMLCEILNARNVISCSLNTQKFFFIIVAASNVYSIFQLCGCLLMFNNIISIRPSERTEPEFNFDLEKGVAFASDSEFPEKSICI
What are the official names of this protein?
Meiotic expression up-regulated protein 31.
Protein: LTOR3_DANRE
Sequence: MADNLRSYLYKQLPSVEGLHAIVVTDRDGAPVIKVANDNAPEYALRPAFLSTFALATDQGSKLGLSKNKSIICYYSTYQIVQFNRLPLVISFIASSNANTGLIFSLEKELVPLIEELRQVVEVA
What is the function of this protein?
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids.  As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.  Adapter protein that may regulate the MAP kinase cascade.
What are the official names of this protein?
Ragulator complex protein LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, Mitogen-activated protein kinase scaffold protein 1.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR3 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TRPD_MYCSJ
Sequence: MAWEHLRVTDTPTWPSILGRLTTGQNLGTGQAAWAMDQIMTGTATPAQIAGFAVAMKLKRPTSAEVTELADVMLKHARRIPTDVIGNETVDIVGTGGDGANTVNLSTMAAIVVAAAGVPVMKHGNRAASSLSGGADTLEALGVRIDLGPEQVAASVAEVGIGFAFANQFHPSYKHASAVRRELGVPTVFNLLGPLTNPARPRAGLIGCAWAELAEVMAGVFASRNSSVLVVHGDDGLDELTTTTTSTIWRVQAGTVERLTFDPAAFGFQRAHLSELVGGDAEYNAAEVRAVLGGAKGAVRDAVVLNAAGALVAHAGLSSDAKWVPAWEAGLARATETIDSGAAEKLLARWVRFTQKL
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RS17E_METBF
Sequence: MGNIRQTNIKRIAFQLLENHRDVFTKDFETNKALVTKYTTIESKVIRNRVAGYVTRKVARMKVY
What are the official names of this protein?
30S ribosomal protein S17e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS17 family.
Protein: RFX1_HUMAN
Sequence: MATQAYTELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGAMRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQALPTQRLVVQSAAPGSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQEVQQLQQVPVPHVYSSQVQYVEGGDASYTASAIRSSTYSYPETPLYTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYVSGSQVVASSTSTGAGASNSSGGGGSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVAVGQQPSTGLSDISAQVQQYQQFLDASRSLPDFTELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGGESPALGPETLEPPAKLARTDARGLFVQALPSS
What is the function of this protein?
Regulatory factor essential for MHC class II genes expression.  Binds to the X boxes of MHC class II genes.  Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.
What are the official names of this protein?
MHC class II regulatory factor RFX1, Enhancer factor C, EF-C, Regulatory factor X 1, RFX, Transcription factor RFX1.
What is the protein family that this protein belongs to?
Belongs to the RFX family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYP_CLOBL
Sequence: MAKDKKFVEDITPMDEDFAQWYTDIVKKAELADYSSIRGCMIIRPNGYAIWENIQKYVDTKLKEYGHENVSMPIFIPENLLQKEKDHVEGFAPEVAWVTHGGDDELAERLCVRPTSETLFCEHYAKIVQSYKDLPKLYNQWCSVVRWEKTTRPFLRTTEFLWQEGHTIHETKEEAESHSLKILNMYSRLCEDMLAMPVVMGKKTDKEKFAGADDTYTIESLMHDGKALQAGTSHYLGQNFSKAFAIQFSDRNGKLDYPHYTTWAVTTRLIGAIIMVHGDNSGLKLPPRIAPTQAVIIPVAQHKEGVLEKAEELKERLAKVVRVKLDDSDKMPGWKYSEYEMKGIPLRIEIGPKDIEKNQAVLVRRDNREKTIVSLDEIEIKVQEMLDIIHNSMLEEAKKTRDEKTYVATNMEEFEDTIENKPGFIKAMWCGDRACEDKIREVTGATSRCMPFEQEVVSDTCVCCGKKAKNLVYWGRAY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSPA_BACCZ
Sequence: MIYYVIALFVIAIDQISKWLIVKNMELGTSIPIIDNVLYITSHRNRGAAWGILENKMWFFYIITVVFVVFIVFYMKKYAKTDKLLGISLGLILGGAIGNFIDRVFRQEVVDFIHVYIFSYNYPVFNIADSALCIGVVLIIIQTLLEGKKTKE
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GET2_DEBHA
Sequence: MSEQPLSQDEKRRLLRERRQAKMARGKASERLNNILSQGSSVKGTTDPVSVFDSKPEPTASSTKPAEVSPAVSSHRDPEDDPDLMDIDNVTPEIKVDEPNIDKMLSDIFGANVGGNATDSSQDDFMANMMNMMKQGEGVDGSTGGTAEPQEPGYQSQLNAYNIYQQRLWKFRFSIIRFAAVLTNFFYHYLTIQDYSFTSSPHFYVRALAPHPAVNSFITWFSTCEVAILASFYLITSKNNIYANASDGNLLLKGISMGAMVLPQLRAYQPLVIRLAHYWEVFSMLLGDIFLVVVLFGLVSIYN
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
What are the official names of this protein?
Golgi to ER traffic protein 2.
What is the protein family that this protein belongs to?
Belongs to the GET2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: SYI_CORJK
Sequence: MSEATPAGGAYPRVDMSNGGSTAFPALEENVLKYWEKDGTFNESVASREGNEEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYQTMQGKKVARVFGWDCHGLPAELEAEKQLGIKDRAGIEEMGMRSFNEYCATSVLRYTDEWKEYVTRQARWVDFDNGYKTMDPGFMESVMWAFKTLYDKGLIYQGFRVLPYSWAEHTPLSNQETRLDDSYKMRQDPTITVTFPITGATEGTASVKTLAEHPELADAAFIGWTTTPWTTPANLALAVNPEVTYAAVRIGDDAAGADGAEGMYGKTVVLADDLRGAYAKELGEKAEVLGTFTGAELEGMTYEPLFGYFAERAGEKASAGEGSEGGEGNQRKPGAFRVLCADYVTTADGTGVVHQAPAFGEDDMFTCEAAGIDLEIPVDMDGKFTSLAPEYQGQLVFDANKAIIKDLKAAGRVLRHQTIEHSYPHSWRSGEPLIYMALPSWFVAVTKFRDRMVELNHEQIEWMPSHIRDGQFGKWLEGARDWNISRNRYWGAPIPVWVSDSEEYPRMDVYGSLEELERDFGRKPASLHRPDIDELTRPNPDDPTGKSTMRRVPEVLDCWFESGSMPFAQKHYPFENKEWFDTHSPADFIVEYSGQTRGWFYTMHVLSTALFDRPAFKKVVAHGIVLGDDGLKMSKSKGNYPNVNEVFDRDGSDAMRWFLMSSPILRGGNLIVTEQGIREGVRQAMLPMWNAYSFLRLYASQPAQYDTSSTNVLDRYILAKLRDTVQGVSDALDNTDIATACDEIRWFCDALTNWYVRRSRDRFWAGDAVHPEAFNTLYTVLETLCRAAAPLLPMTTEVIWRGLTGERSVHLADFPKSENLPADAELVTAMDAVRAVSSATSSLRKAHKLRNRLPLPKLTVALPNASALEDFTKIIADEVNVKQVELTEDVAQVGGFEVVVNARVAGPRLGKDVQRVIKAVKSGNYTVDDAGVVTADGIELQDGEFTRKLVAAEPEHTAEVSGQDGLVVLDTQTTPELEAEGWAADRVRGLQEARKAADLQISDRIHLTLSVPAEKEEWARTHADSIAKEVLATDVKVVVGEQLSHDVADDCSADIVVASVAS
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JAM2_HUMAN
Sequence: MARRSRHRLLLLLLRYLVVALGYHKAYGFSAPKDQQVVTAVEYQEAILACKTPKKTVSSRLEWKKLGRSVSFVYYQQTLQGDFKNRAEMIDFNIRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAPAVPSCEVPSSALSGTVVELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARNSVGYRRCPGKRMQVDDLNISGIIAAVVVVALVISVCGLGVCYAQRKGYFSKETSFQKSNSSSKATTMSENDFKHTKSFII
What is the function of this protein?
Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068).  Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068).  At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068).  Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159).  Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135).  Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity).  Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity).  During myogenesis, it is involved in myocyte fusion (By similarity).  May also play a role in angiogenesis (By similarity).
What are the official names of this protein?
Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction. Note=Localized at tight junctions of both epithelial and endothelial cells (By similarity). Specifically localized within the somatodendritic compartment of neurons and excluded from the axon (By similarity).
Protein: RTF2_SCHPO
Sequence: MGNDGGSLPTRNELVKEPGKVPPLDIDFKRSVKSSQFSQCAITDEPLYPPIVSCGLGKLYNKASILQMLLDRSSVPKSPSHIKSLKDVVQLQVELDDSGKVLWLCPITRHVMSDTYQFAYIVPCGHVFEYSALKQFGEKMCFQCNQVYEEKDVIPINPNAEQLKTLSKRLLDLALSEKTHSLNKASKKSNKNGDKKRKHVSKSNSKHAKHELRTNRMLDGENVKSETSVTDMERVKRVKI
What is the function of this protein?
Replication termination factor which mediates replication termination at the site-specific replication barrier RTS1.  Stabilizes the replication fork stalled at RTS1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin.
What are the official names of this protein?
Replication termination factor 2.
What is the protein family that this protein belongs to?
Belongs to the rtf2 family.
Protein: SYP_LEPIC
Sequence: MKASKYILPTEKENPADAVVASHRLMIRAGLVRKSSAGLYFYLPLGLKVLKKIEQIVREEMNSTGALEFDLPILTPSDFWEQSGRWSAMGKEMFRIQDRHDLSYALGPTHEESFSFLLKPLLKSYKDLPVNVYQIQTKFRDEIRPRFGVIRSREFIMKDAYSFHIDDSSLDDTYQAMRVAYRKIFDRCGLKTIPVQADSGSMGGSASEEFMVVSPIGEETLLLCNSCGYSSNSEKTPLILKKENGSAKFSEKKEISTPGKKTISEVSTLLGVSESETIKAVALKSEKKKILVFLRGDLELNLHKLHSLLKIADSEPMTDLEIRELGLIPGFISPIAPNDKIKVLYDRSLQKDFPYVVGSSKEDFHTQGFILEKEISGLPEFADVALAREGDLCPNCSSPLKAEKGIEVGHIFKLGDKYTKAFGIQVLDQNGKSKTLTTGCYGIGVNRTMATVIEQCNDEKGIFWPISIAPFEVSLVSIVKGEDQYSKIEEFYNVLINEGIEVFWDDRDLGPGFKLKDSELIGFPIRITIGKKFFESGEISIYNRKKDQEDSFVFSGFDDLVARVESMRQELFTELR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG7_ARATH
Sequence: MAEKETPAIILQFAPLNSSVDEGFWHSFSSLKLDKLGIDDSPISITGFYGPCGHPQVSNHLTLLSESLPLDEQSLIASTSHGNRNKCPVPGILYNTNTVESFNKLDKQSLLKAEANKIWEDIQSGKALEDPSVLPRFLVISFADLKKWSFRYWFAFPAFVLDPPVSLIELKPASEYFSSEEAESVSAACNDWRDSDLTTDVPFFLVSVSSDSKASIRHLKDLEACQGDHQKLLFGFYDPCHLPSNPGWPLRNYLALIRSRWNLETVWFFCYRESRGFADLNLSLVGQASITLSSGESAETVPNSVGWELNKGKRVPRSISLANSMDPTRLAVSAVDLNLKLMRWRALPSLNLNVLSSVKCLLLGAGTLGCQVARTLMGWGIRNITFVDYGKVAMSNPVRQSLYNFEDCLGRGEFKAVAAVKSLKQIFPAMETSGVVMAIPMPGHPISSQEEDSVLGDCKRLSELIESHDAVFLLTDTRESRWLPSLLCANANKIAINAALGFDSYMVMRHGAGPTSLSDDMQNLDINKTNTQRLGCYFCNDVVAPQDSMTDRTLDQQCTVTRPGLAPIAGALAVELLVGVLQHPLGINAKGDNSSLSNTGNNDDSPLGILPHQIRGSVSQFSQITLLGQASNSCTACSETVISEYRERGNSFILEAINHPTYLEDLTGLTELKKAANSFNLDWEDDDTDDDDVAVDL
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes.  Involved in the senescence process (PubMed:12070171).  Involved in the degradation of damaged peroxisomes (PubMed:24368788).  Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing (PubMed:24510943).
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme atg7, ATG12-activating enzyme E1 atg7, Autophagy-related protein 7, AtAPG7, Protein PEROXISOME UNUSUAL POSITIONING 4.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
Protein: RL34_MYCSJ
Sequence: MAKGKRTFQPNNRRRARVHGFRLRMRTRAGRAIVTGRRRKGRRSLTA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PGA19_CANAL
Sequence: MFSTTSIVLWFTILLPVTLPVSIDNRDLLLKRHVEPNDIQFFNQGVRSSLSYIYQKRDVSDSDNEQVLRKSKKKKKTTSTGTPGNENTTDFASAQEFEKWEGDREGWQISAGLYFDKAIASDSCDSDSEDEDEGRKKFWIFTDDAPVDNENLIVSSEDKLELNYISSGKNLEGLTKVIRKAKGNSTTYNQSKIKFNVDAQGEDQFESGFGSLIPYNSFYLYILLFCIIF
What is the function of this protein?
Predicted GPI-anchored protein which may have a role during host infection.
What are the official names of this protein?
Predicted GPI-anchored protein 19.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: EPTB_ECOLI
Sequence: MRYIKSITQQKLSFLLAIYIGLFMNGAVFYRRFGSYAHDFTVWKGISAVVELAATVLVTFFLLRLLSLFGRRSWRILASLVVLFSAGASYYMTFLNVVIGYGIIASVMTTDIDLSKEVVGLNFILWLIAVSALPLILIWNNRCRYTLLRQLRTPGQRIRSLAVVVLAGIMVWAPIRLLDIQQKKVERATGVDLPSYGGVVANSYLPSNWLSALGLYAWARVDESSDNNSLLNPAKKFTYQAPQNVDDTYVVFIIGETTRWDHMGIFGYERNTTPKLAQEKNLAAFRGYSCDTATKLSLRCMFVRQGGAEDNPQRTLKEQNIFAVLKQLGFSSDLYAMQSEMWFYSNTMADNIAYREQIGAEPRNRGKPVDDMLLVDEMQQSLGRNPDGKHLIILHTKGSHFNYTQRYPRSFAQWKPECIGVDSGCTKAQMINSYDNSVTYVDHFISSVIDQVRDKKAIVFYAADHGESINEREHLHGTPRELAPPEQFRVPMMVWMSDKYLENPANAQAFAQLKKEADMKVPRRHVELYDTIMGCLGYTSPDGGINENNNWCHIPQAKEAAAN
What is the function of this protein?
Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A.  Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol.
What are the official names of this protein?
Kdo(2)-lipid A phosphoethanolamine 7''-transferase, Phosphoethanolamine transferase EptB.
What is the protein family that this protein belongs to?
Belongs to the phosphoethanolamine transferase family. EptB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSLV_YERP3
Sequence: MTTIVSVRRDGHVVIGGDGQVTLGNTVMKGNAKKVRRLYNNKVIAGFAGGTADAFTLFELFERKLEMHQGHLTKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPEDDLIAIGSGGPYAQSAARALLENTELGARDIVEKSLSIAGDICIYTNRFQTIEELTY
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RB33B_PONAB
Sequence: MAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKIQLWDTAGQERFRKSMVQHYYRNVHAVVFVYDMTNMASFHSLPSWIEECKQHLLASDIPRILVGNKCDLRSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLAHKLKSHKPLMLSQPPDNGIILKPEPKPAMTCWC
What is the function of this protein?
Protein transport.  Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity).  It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity).
What are the official names of this protein?
Ras-related protein Rab-33B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Golgi apparatus, cis-Golgi network. Note=Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm.
Protein: CUE1_CANGA
Sequence: MEHSAAVVVATLILGIFVVKWFAAPKEHPSAQRLPNTQLPSSSNNQQRTAGSSNGRGSQRRVSSTSRRNITPEMIETVRNVIPALHPEQIRYDLESTGSVEQTMERYFNGESFPFPPGYTPARESSANGQHNNIDEPSDIRKRSNIRPDNLLSKFNVDMSVDMSDMSIKELEIDERKKLLVWEARKNMEKRLETDTELASLIK
What is the function of this protein?
Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway.  Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system.  Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
What are the official names of this protein?
Coupling of ubiquitin conjugation to ER degradation protein 1.
What is the protein family that this protein belongs to?
Belongs to the CUE1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.