PharMolix/UniProtQA huggingface dataset:
Protein: ARGC_ECOLI
Sequence: MLNTLIVGASGYAGAELVTYVNRHPHMNITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQPMSDISEFSPGVDVVFLATAHEVSHDLAPQFLEAGCVVFDLSGAFRVNDATFYEKYYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQLALKPLIDADLLDLNQWPVINATSGVSGAGRKAAISNSFCEVSLQPYGVFTHRHQPEIATHLGADVIFTPHLGNFPRGILETITCRLKSGVTQAQVAQVLQQAYAHKPLVRLYDKGVPALKNVVGLPFCDIGFAVQGEHLIIVATEDNLLKGAAAQAVQCANIRFGYAETQSLI
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F187A_BOVIN
Sequence: MNLAHTTVLLWAWGSLQAFEIVEKENIFQRTPCPAFLMFDNAAYLTDMSFELPCPCKPEEVSAVVWYYQKHLGSSHTKVLTDFDGRVLTEAAQVRVGSDMLVRFSIRMFSLLVFRAQPEDSGLYFCGTRKGDYFYAYDVDIQSSEGMVATFKDQGQEPLEDEYHGSLRVFTTFWEWTPCDRCGVRGEQWRIGLCYLQSPDLSPRYRKILPNVVSCGSRAVPRQLRAKASDHNPELLVRSCLMPCEKKKKVQEGVMAIFNYVSKVGSRPWLPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDHQYLYRTQYLKGVNGSMRVFIDHGNHLHIRFTQLEDRGIYYCWRQGERIAGFRLGVTSPGRYPVSFSDPETRAALGLILIGYMLITVIFISIHLCRCCCYLFRFCPNFSPRLSRPQL
What are the official names of this protein?
Ig-like V-type domain-containing protein FAM187A.
What is the protein family that this protein belongs to?
Belongs to the FAM187 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: BIRA_MYCTU
Sequence: MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR
What is the function of this protein?
Catalyzes the transfer of biotin onto a conserved lysine residue of the biotin carboxyl carrier protein (BCCP) domain of acetyl-CoA carboxylase and converts it to active holo-BCCP (PubMed:18509457, PubMed:24723382).  Forms an acyl-adenylate intermediate (PubMed:18509457, PubMed:24723382).  Cannot use GTP or desthiobiotin (PubMed:18509457).
What are the official names of this protein?
Biotin--[acetyl-CoA-carboxylase] ligase, Biotin--[biotin carboxyl-carrier protein] ligase, Biotin--protein ligase, BPL, Biotin-[acetyl-CoA carboxylase] synthetase.
What is the protein family that this protein belongs to?
Belongs to the biotin--protein ligase family.
Protein: GLGS_ECOL5
Sequence: MDHSLNSLNNFDFLARSFARMHAEGRPVDILAVTGNMDEEHRTWFCARYAWYCQQMMQTRELELEH
What is the function of this protein?
Major determinant of cell surface composition.  Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.
What are the official names of this protein?
Surface composition regulator.
What is the protein family that this protein belongs to?
Belongs to the GlgS family.
Protein: ZN367_MOUSE
Sequence: MIRGAPAPMAEPPPVVFCHDSPKRVLVSVIRTTPATPPCSSVGEPEPPPPLVPTSPGFSDFMVYPWRWGENAHNVTLSPGAAGGVVSAGLPVAAELPTLRGAPQSSASVAAVSGGEDEEEASSPDSGHLKDGIRRGRPRADTVRDLINEGEHSSSRIRCNICNRVFPREKSLQAHKRTHTGERPYLCDYPDCGKAFVQSGQLKTHQRLHTGEKPFVCSENGCLSRFTHANRHCPKHPYARLKREEPTDALSKHQSPDNKAAAEWLAKYWEMREQRTPTLKGKLVQKADQEQQDPLEYLQSDEEDDEKSGAQRRLQEQRERLHGALALIELANLTGAPLRQ
What is the function of this protein?
Transcriptional activator.  Isoform 1 may be involved in transcriptional activation of erythroid genes (By similarity).
What are the official names of this protein?
Zinc finger protein 367, C2H2 zinc finger protein ZFF29.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: F16PA_VIBCH
Sequence: MQKMRTLGEFIVEKQHDFPHASGELSSLLASIRLAAKIVNREINKAGLADIIGASGNDNIQGEEQQKLDLYANEKFKAALEARDQVCGVASEEEDEAVAFSKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVSPVGTPPTQEDFLQPGNKQVAAGYVIYGSSTMLVYTTGNGVNGFTYDPSLGTFYLSHENMRIPENGKIYSINEGNYIRFPTGVKKYIKFCQENVPEEGRPYTSRYIGSLVADFHRNLLKGGIYLYPSTQSHPNGKLRLLYECNPMAFLIEQAGGLASDGARRIMDIKPTELHQRVPFFVGSKNMVHKVETFLETYPD
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_CAMJJ
Sequence: MSQKILFIDRDGTLIEEPKSDFQIDTLEKLRFEKDAIPTLLKLKNFGFKFVMVSNQDGLGTPSFPKENFEIAHEKMLDILKSCGIEFQDIFICPHFENENCACRKPKTAMLEEYIKHELYDKEQSFVIGDRESDMILASNLGVRGLRYGELSWKEIENEILSSFRSASYQRTTKETDIKVKVCLNGGKISIKTGIDFFDHMLEQIAVHGGIGLEISCKGDLEIDEHHSVEDVALALGACIKKALGDKIGIARYGFALPMDECLASCAMDFCNRPHLVYKAKFKKSHLGALSTEMIEHFFYSLSYAMGVSLHLKVKGKNDHHKAEGLFKAFAKALKMAVKIESENLASSKGVI
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SO9L_BUNMU
Sequence: MKTLLLTLVVLTIACLDLGYTKTCFNDDLTNPKTTELCRHSVYFCFKNSRIAGGVERMQRGCSLTCPDIKYNGKYIYCCTRDNCNA
What are the official names of this protein?
Cardiotoxin homolog TA-ctx-like.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Orphan group IX sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KI3L3_HUMAN
Sequence: MSLMVVSMACVGFFLLEGPWPHVGGQDKPFLSAWPGTVVSEGQHVTLQCRSRLGFNEFSLSKEDGMPVPELYNRIFRNSFLMGPVTPAHAGTYRCCSSHPHSPTGWSAPSNPVVIMVTGVHRKPSLLAHPGPLVKSGETVILQCWSDVRFERFLLHREGITEDPLRLVGQLHDAGSQVNYSMGPMTPALAGTYRCFGSVTHLPYELSAPSDPLDIVVVGLYGKPSLSAQPGPTVQAGENVTLSCSSRSLFDIYHLSREAEAGELRLTAVLRVNGTFQANFPLGPVTHGGNYRCFGSFRALPHAWSDPSDPLPVSVTGNSRHLHVLIGTSVVIIPFAILLFFLLHRWCANKKNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDTSV
What is the function of this protein?
Receptor on natural killer cells.  May inhibit the activity of NK cells thus preventing cell lysis.
What are the official names of this protein?
Killer cell immunoglobulin-like receptor 3DL3, CD158 antigen-like family member Z, Killer cell inhibitory receptor 1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ACHA5_CHICK
Sequence: MPLRARSRKPGAGPAARAPQAGVSEPSFVAKSEDRLFKHLFEDYQRWVRPVEHLNDTIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIHVKLRWNPEDYAGITSIRVPSDSIWIPDIVLYDNADGRFEGTSTKTVVKYDGTIAWTPPVNYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDYEVDKRDFFDNGEWEIVTATGSKGNRTDGCCWYPFVTYSFIIRRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEAEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHVDRYFAQKEEKGNMSGSESSRNTLEAALDSIRYITRHVMKENEVREVVEDWKFIAQVLDRMFLWAFLLVSIIGSLVLFIPVIHKWASIIVPVHIGSTNT
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-5.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: Y05A_BPT4
Sequence: MKTRSQIEDMVRNASYTRDVMTFLCENNLDPDKVNRVIHHFKYTNSSEWVRNFSKAGYITQMTAREQLTDFCKTIDYKNPLFVQGVGQSKVDLSSGFFNPNHYRIEWRFIALFRRQLKQILSTASRLKGSDINLKNLKFDGYTLQMEVRPLKENNRTARISFKPNTKNSLSICECLKSQLTEAFKYMDVVAAVQSKILPRFERFKLDTTSYELDMIVSFKYEFLRKDEVTQEKKQEVQDNLNLSNYLSNDPKFWMYSSGNKDAWKFNKVNFLPVENPSLKPVEKWHADAIEKSLKAVDAELVKATNEVLEAEKALEQAQSRVQNLTKQRSKLNNALNALN
What are the official names of this protein?
Uncharacterized 39.7 kDa protein in nrdC-mobD intergenic region.
Protein: ASSY_LISW6
Sequence: MTKEKIVLAYSGGLDTSVAIQWLVESGYEVIACCLDVGEGKNLDFIKEKAITVGASESYTIDAKEEFAEDFALIALQAHAYYEGKYPLISALSRPLIAKKLVEVARQEGASAIAHGCTGKGNDQVRFEVAIHALAPDLKVISPVRDWKWSREEEINYAKEHNIPVPIDLDNPFSIDQNLWGRSNECGVLENPWTTPPEAAYDLTVSLEDAPDTADIVEITFDAGIPISLNGENMSLANLILTLNEIAGKHGVGRIDHIENRLVGIKSREVYECPAAVTLIKAHKELEDLTFVREVAHFKPIIEQKISETIYNGLWFSPLTEALVAFLKSTQKFVNGTIRVKLFKGHAIVEGRKSPNSLYDENLATYTSSDTFDQDAAVGFIKLWGLPTKVSAEVNSKVTITTEV
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_BRUME
Sequence: MSHNSFGHLFRVTTWGESHGLALGCVVDGCPPGITFTEAEIQSFLDKRKPGQSKYTTQRREPDQVRVLSGVLLGEDGVTMTTTGTPISMMIENTDQRSKDYGEIARQYRPGHADYAYDVKYGIRDYRGGGRSSARETAARVAAGAIARKVVPGLEVRGALVSIGAHDIDRSRWNWAEVDNNPFFTPDAGSVEVFADYLDGIRKNGSSVGAIIEIVAEGVPAGIGAPIYGKLDQDIASYLMSINAVKGVEIGNGFEAARLTGEENADEMRMGNDGKPIFLSNHAGGVLGGIATGAPVVARFAVKPTSSILTPRRSIDKDGNEVDVMTRGRHDPCVGIRAVPIGEAMVACAIADHYLRHRGQTGRV
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RIP_RAT
Sequence: MAESSGSPHRLLYKQVGSPPWKETFRQGCLERMRNSRHKLLNRYRQAAGSTLGTASDRLLVQEVMEEEWNSLQSVENCPEALLQLELPLNLAVLQDIEQELWNEEKSIISEYEKGLQFDESCLNSMLAEWEANPLICPVCIKYNLRIMNSVVTCPCGLHIPSHSTDLTEQKLRACLEGNVNEHSAHCPHIPEFSVTGGTEEKPSLLMSCLACDTWAVIL
What is the function of this protein?
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta.  Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity).
What are the official names of this protein?
RPA-interacting protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: MUKB_YERPN
Sequence: MIERGKFRSLTLVNWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLRAGVCYSTLDVVNSRHQRVVVGVRLQQVAGRDRKVDIKPFTIQGLPTAIQPTEILTELVAERQARVLSLPELKERVEAMEGVQFKQFNSITDYHSLMFDLGVIPKRLRSSADRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATSYVAADYMRHANERRIHLDSALVLRRDLFSSRKQLVTEQYRHVEMSRELAEQSGAESDLETDYQAASDHLNLVQTAMRQQEKIERYQSDLEELTYRLEEQSEVVSEASEQQADNEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYQQALQALERARALCQLPELTADNAEEWLETFHAKEQEATESLLQLEQKLSVADAAHSQFEQAYQLVVNIAGEVSRSEAWQTARELLRDWPSQQHLAERVQPLRMRLSELEQRLRAQQDAERLLQEFCKRQGNAYQPEELEALQRELESQVEELSLSVSDAGERRMAMRQELEQLKLKIQELTARAPVWLAAQDALSQLSEQSGEALEDSRQVTEYMQQLLERERETTVERDEIAASKRAIEAQIERLSQPSGAEDARLIALAERFGGVLLSEIYDDVTIDDAPYFSALYGPSRHGIVVPDLSLVREHLQGLDDCPEDLYLIEGDPQSFDDSVFAVEEHEKAVVVKIADRQWRYSRYPEVPLFGRAARENRLETLYQERDRLAERYATLSFDVQKTQRTHQAFSRFIGSHLAVAFDADPEAEIRLLNTRRGEIERALNAHEDQNQQQRQQFDQAKEGISALNRLIPLVSLLLDETLTDRVEEITEELAEAQEAARYIQQHGVSLTKLEPLLSVLQSDPQQHEQLQESYVLAQNSQRLAKQQAFALTEVVQRRAHFSYTDSAGMLTENSDLNDKLRQRLEQAEAERTRAREQLRQYQSQFTQYSQVLASLKSSYDAKRDMLKELSQELVDIGVPADANAEARARARRDELHAALSTNRSRRNQLEKQLTFCEAEMDSLQKKLRKLERDYHQIREQVVNAKAGWCAVMRMVKDNGVERRLHRRELAYMDGDELRSMSDKALGALRLAVADNEHLRDVLRLSEDPKRPERKIQFYIAVYQHLRERIRQDIIRTDDPVEAIEQMEIELGRLTEELTAREQKLAISSKSVSNIIRKTIHREQNRIRMLNQGLQAVSFGQVKSVRLNVNVREAHATLLDVLSEQQEQHQDLFNSNRLTFSEALAKLYQRLNPQMDMGQRLPQTIGEELLDYRNYLELEVEVYRGADGWLRAESGALSTGEAIGTGMSILVMVVQSWEEESRRLRGKDISPCRLLFLDEAARLDAKSIATLFELCERLEMQLIIAAPENISPEKGTTYKLVRKVFQNHEHVHVVGLRGFANEMPSLPPIAAELQQGG
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: P63_MOUSE
Sequence: MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE
What is the function of this protein?
Acts as a sequence specific DNA binding transcriptional activator or repressor.  The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity.  May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.  Involved in Notch signaling by probably inducing JAG1 and JAG2.  Activates transcription of the p21 promoter (By similarity).  Activates RIPK4 transcription.  Plays a role in the regulation of epithelial morphogenesis.  The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm.  Required for limb formation from the apical ectodermal ridge.
What are the official names of this protein?
Tumor protein 63, p63, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTS_CHLFF
Sequence: MSNFSMETLKLLRQQTGVGLTKCKEALAECNGNLEEAVVYLRKLGLASASKKEHRETKEGVIAAKSDARGTAIVEVNVETDFVANNAVFRSFVDGLVEDVLNHKADNVDALLQLPSFQDASLTVDELRAVTMQTVGENIRISRIKYFPKTTEESVGIYSHGNGKAVSITILSGLSDQESLAKDISMHIVAAQPLFLSKESVPEDALAKEKEIISSQIQGKPQAVIDKIISGKLGTFFQDVCLLEQAYIKNPDTTIQHLINGVSKTSGNSVEVKEFILWKIGA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRC_VIBC3
Sequence: MASNNDSIKKTLFVVIALSLVCSIIVSAAAVGLRDKQKENAALDKQSKILQVAGIEAKGSKQIVELFNKSIEPRLVDFNTGDFVEGDAANYDQRKAAKEASESIKLTAEQDKAKIQRRANVGVVYLVKDGDKTSKVILPVHGNGLWSMMYAFVAVETDGNTVSGLTYYEQGETPGLGGEVENPAWRAQWVGKKLFDENHKPAIKIVKGGAPQGSEHGVDGLSGATLTSNGVQNTFDFWLGDMGFGPFLTKVRDGGLN
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit C, Na(+)-NQR subunit C, Na(+)-translocating NQR subunit C, NQR complex subunit C, NQR-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the NqrC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RF2_PASMU
Sequence: MFEINPIRNKISDLTERTQVLRGYLDFDAKVERLEEVNAELEQPDVWNEPEKAQALGKERVALEGVVNTIHTLDQGLEDVEGLLELAIEAEDEATFHEAVAELEELEQQLAKLEFRRMFSGQHDAADCYVDLQAGSGGTEAQDWTEMLLRMYLRWAESKGFKTELMEVSDGDVAGIKSATIKVSGEYAFGWLRTETGIHRLVRKSPFDSNNRRHTSFSAAFVYPEIDDDIDIDINPADLRIDVYRASGAGGQHVNKTESAVRITHIPSGIVVQCQNDRSQHKNKDQCMKQLKAKLYEMELQKKNADKQAMEDNKSDIGWGSQIRSYVLDDSRIKDLRTGVENRNTQAVLDGDLDRFIEASLKAGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EREP2_MOUSE
Sequence: MPPAGGPRTPRPHALPRSLSRLRECPGRSRIVLALGATQMALGCLIVAVSFAALALTTSARVRHSCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSILSCQNAQLVSSLEGCQLIKFDSVEVCVCCELQHHSSGCSNLGETLKLNPLQENCNAVRLTLKDLLFSVCALNVLSTIVCALATAMCCMQMVSADVLQMFFPHRSHSANAACVTPHGTILHQTLDFDEFIAPLPPPPYYPPEYTCTPTAEAHRGLHLDFASSPFSTLYDVAINSPGILYPAELPPPYEAVVGQTPASQVASVDHQVVDSSSGDPNTAADFSTPVPASSTSLPTSEGATSLGPSHPSPDGTLDTPTPLIPTPVPHHMSPEAASLSAQAQPSPGRVARSVSDPTSCTSSEAVSTSQPAMAACQHQHSSTGDPDTWKTGQGTKPETLQTVSKERPHSLVESKAYADTRVLVAKFLEHAHCSLPTEVRHVVGTIRSMATSEEPRVEEAIFGAGVLDQL
What are the official names of this protein?
Protein ENTREP2, Endosomal transmembrane epsin interactor 2.
What is the protein family that this protein belongs to?
Belongs to the ENTREP family.
Protein: CP51C_GIBZE
Sequence: MESLYETLRTLPLSVSIPLTTSIIIILSIVTNVVKQLWFPNPHRPPVVFHIFPFIGSTVQYGIDPYAFFFDCRDKYGDCFTFILLGKSTTVFLGPKGNDFILNGKHADLNAEDVYGKLTTPVFGEEVVYDCSNARFMDQKRLLKLGLTTDSLRCYIPKFVKEVEDYVKNSPYFKGDTGIVNITEVMAEITIYTASGSLLGNEVRSMFDSTFATLYRHLDDGFQPINFVMPGLPLPQNFRRNHARKVMEKLFSDIISKRRETGNQGDETDMIWMLMNAQYKDGEPLPDHHAARMLIAILMGGQHNTAVSGAWLLLNLAHKPHLVQELYEEQTQVLGSPQEPLTWENLQKLTLNGQVIKETLRLHSPIHSILRQVKSPMRVPGTEWVVPPSHTLLSSPGTMARSEEFFPRPSEWDPHRWDKIEPLVKTAEDGQTVDYGFGVMSKSVSSPYLPFGAGRHRCVGENYAYAQLGAIVATFIRLVHIEQPDPKAPLPAPDYSSMFSRPMNPAEIRWRRRETVE
What is the function of this protein?
Together with cyp51A and cyp51B, encodes the sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:20955812).  Cyp51C does not seem to encode an active sterol 14-alpha-demethylase, but can impact indirectly on sterol 14alpha-demethylation, and is required for full virulence on host wheat ears, but not on Arabidopsis floral tissue or the fruits of apple and tomato (PubMed:20955812, PubMed:23442154).  The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity).  In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity).  Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (By similarity).
What are the official names of this protein?
Sterol 14-alpha demethylase CYP51C, CYP51C, Ergosterol biosynthetic protein CYP51C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: DXS_RHOPB
Sequence: MSEFSKTPLLDTIRTPADLRKLRIDQVRQVADELRQETIEAVSVTGGHFGAGLGVVELTTAIHYVFDTPRDRLIWDVGHQAYPHKILTGRRDRIRTLRTGGGLSGFTKRTESDYDPFGAAHSSTSISAGLGMAVARDLAGGKNNVIAVIGDGSISAGMAYEAMNNAGAMNSRLIVILNDNNMSIAPPVGAMSAYLSRLYSGKTYRTLREAGKQIGKHLPKLIADRAARAEEYSRGFMMGGGTLFEELGFYYVGPVDGHNLDHLLPILQNVRDADTGPFLIHVVTQKGKGYGPAEAASDKYHAVVKFDIATGAQAKAKSNAPSYQNVFGQSLVKEAQKDDKIVGITAAMPSGTGIDIFEKAFPTRTFDVGIAEQHAVTFAAGLAAEGYKPFCAIYSTFLQRGYDQVVHDVAIQSLPVRFAIDRAGLVGADGATHAGSFDNAFLGCLPNMVIMAASDEAELVHMVATQVAINDRPSAVRYPRGEGRGVEMPEVGIALEIGKGRIVREGNKIALLSFGTRLAECEKAADELATLGLSTTIADARFMKPLDVELVLKLARDHEILLTIEEGSIGGFGSHVMQTLAEHGMLDGEVRMRSLVLPDEFMDHDTPTAMYARAGLDAKGIVKKVFEALGKDAKTDTVKLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: NHX6_ARATH
Sequence: MSSELQISPAIHDPQGQEKQQQAAGVGILLQIMMLVLSFVLGHVLRRHKFYYLPEASASLLIGLIVGGLANISNTETSIRTWFNFHDEFFFLFLLPPIIFQSGFSLQPKPFFSNFGAIVTFSVLGTFVASMVTGLLVYLGGVMFLMYRLPFVECLMFGSLISATDPVTVLSIFQELGSDVNLYALVFGESVLNDAMAISLYRTMSLVRSHSSGQNFFMVIVRFLETFVGSMSAGVGVGFTSALLFKYAGLDVDNLQNLECCLFVLFPYFSYMLAEGLSLSGIVSILFTGIVMKHYTYSNLSANSQRFVSAFFHLISSLAETFVFIYMGFDIAMEKHSWSHLGFIFFSILFIVIARAANVFGCGYLVNLARPAHRKIPMTHQKALWYSGLRGAMAFALALQSVHDLPEGHGQTIFTATTAIVVLTVLLIGGSTGTMLEALEVVGDSHDTSLGDGFEVVNSRYMTSYDDEDTPPGSGFRTKLREFHKSAASFTELDRNYLTPFFTSNNGDYDDEGNMEQHHEERIPFTRRGNLNNRG
What is the function of this protein?
Involved in trafficking to the vacuole (PubMed:21278129).  Required for cell proliferation and cell expansion, but not for cell differentiation (PubMed:21278129).  Acts in low affinity electroneutral exchange of protons for cations such as Na(+) or K(+) across membranes (By similarity).  May also exchange Li(+) and Cs(+) with a lower affinity (By similarity).
What are the official names of this protein?
Sodium/hydrogen exchanger 6, Na(+)/H(+) exchanger 6, NHE-6.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Protein: HIS1_XANC8
Sequence: MSASTAAPARDRLRIAIQKNGRLAEPARSLLAACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIADGVCDLGIVGQNELDEQASARRRAGLPAAYHAVRGVGFGQCRLMLAVPEEWDWQGVAQLAGKRIATSYPAILADWLERQGIDASVVELSGSVEIAPRLGTADLICDLVSSGATLAANQLKPVELVMESEAVLAGAVREPADARAALLAMLLRRMDGVLKLRDSKLLMFRAEQGNVDALRRLLPDADPLVQLPDDGNGALRLQTMCHGAVTWQRLEELERAGAQGLMVLTVERSLA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.