PharMolix/UniProtQA huggingface dataset:
Protein: YNGC_BACSU
Sequence: MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSEGTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQKYGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQWDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR
What are the official names of this protein?
Uncharacterized membrane protein YngC.
What is the protein family that this protein belongs to?
Belongs to the DedA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISCS_PASMU
Sequence: MKLPIYLDYAATCPVDERVAKKMMEYLTVEGNFGNPASRSHKFGWQAEEAVDVARNYIADLIGADSREIVFTSGATESDNLAIKGAAHFYQSKGKHIITCKTEHKAVLDTCRQLEREGFEVTYLNPKSDGLIDLEELKNAMRDDTILVSIMHVNNEIGVIQDIAAIGELCRARKILFHVDATQSVGKLPINLAELKVDLMSMSSHKLYGPKGIGALYVSRKPRVRLEAIIHGGGHERGMRSGTLPVHQIVGMGEAYRICKEEMASEMPRLKALRDRLYNGLKDIEETYVNGSMEHRLDSNLNISFNYVEGESLMMALRDIAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFTLGRYTTEEEIDYTIELVKNAVAKLRELSPLWDMFKEGIDLNTIEWTHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHEU_SALPK
Sequence: MIIPWQGLAPDTLDNLIESFVLREGTDYGEHERSLEQKVADVKRQLQSGEAVLVWSELHETVNIMPKKQFRE
What are the official names of this protein?
UPF0270 protein YheU.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: RL2_STRP3
Sequence: MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVSLKSKAGRNNNGRITVRHQGGGHKRHYRLIDFKRNKDGVEAVVKTIEYDPNRTANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPDADIKVGNALPLANIPVGTVVHNIELKPGKGGELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATIGTVGNEQQSLVNIGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MATK_WEDBI
Sequence: MEKFQSYLGLDRSHYFLYPLIFQEYIYVLAHDHGLNGSILLENAGYDNKSSLLIVKRLIIRMYQQNHLILSVNDSKQTPFWGHNKNFYSQVMSEVSSTIMEIPLSLRLISSLERKGVVKSDNLRSIHSIFSFLEDNFSHLNYVLDILIPYPAHLEILVQALRYWIKDASSLHLLRFFLYECHNRDSLITSNSKKACSSFSKRNHRLFCFLYTSYLCEYESGFLFLRNQSSHLRSTSSGALIERIYFYGKIEHLAEVFAGAFQANFWLFKDSFMHYVRYQGKSILASKGTFLLMNKWKYYFVNFWKSSFYLWSHPGGIYINQLSNHSLDFLGYRSSVRLKPSMVRGQMLENTFLIDNAIKKFDSLVPIMPLVGSLAKSKFCNALGHPIGKAIWTDLSDSDIIERFGRIYRKLSHYHSGSSKKKGLYRVKYILRLSCARTLARKHKSTVRAFLKRFGSQLLEEFFTEEEQVFPLTFPRVSSISRRLSRRRIWYLDIVCINDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IDND_ECOLI
Sequence: MQVKTQSCVVAGKKTVAVTEQTIDWNNNGTLVQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIHSDSSELHEGQTVAINPSKPCGHCKYCIEHNENQCTDMRFFGSAMYFPHVDGGFTRYKMVETSQCVPYPAKADEKVMAFAEPLAVAIHAAHQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSFEVSGHPSSVNTCLEVTRARGVMVQVGMGGAMAEFPMMTLIGKEISLRGSFRFTSEFNTAVSWLANGVINPLPLLSAEYPFTDLEEALRFAGDKTQAAKVQLVF
What is the function of this protein?
Catalyzes the NADH/NADPH-dependent oxidation of L-idonate to 5-ketogluconate (5KG).
What are the official names of this protein?
L-idonate 5-dehydrogenase (NAD(P)(+)).
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: PQQE_METPB
Sequence: MNAPTPAPSPADVIPAPVGLLAELTHRCPLRCPYCSNPLELDRRSAELDTQAWLRVLTEAAGLGVLHVHLSGGEPTARPDIVEITAKCAELGLYSNLITSGVGGALAKLDALYDAGLDHVQLSVQGVDAANAEKIGGLKNAQPQKMQFAARVTELGLPLTLNSVIHRGNIHEVPGFIDLAVKLGAKRLEVAHTQYYGWAYVNRAALMPDKAQVDESIRIVEAARERLKGQLVIDLVVPDYYAKYPKACAGGWGRKLMNVTPQGKVLPCHAAETIPGLEFWYVTDHALGDIWTKSPAFAAYRGTGWMKEPCRSCDRREKDWGGCRCQALALTGDAANTDPACSLSPLHAKMRDLAKEEAAENPPDYIYRSIGTNVQNPLSEKAPL
What is the function of this protein?
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
What are the official names of this protein?
PqqA peptide cyclase, Coenzyme PQQ synthesis protein E, Pyrroloquinoline quinone biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PqqE family.
Protein: GRA3_POGPU
Sequence: NWRKILGQIASVGAGLLGSLLAGYE
What is the function of this protein?
Thanks to its abundant amphiphilic alpha-helices, it may integrate into membrane phospholipids, leading to lysis of the membrane.  Has hemolytic activity.  Has antibacterial activity with a broad spectrum against various species of bacteria including both Gram-positive and Gram-negative groups.  Has also ichthyotoxic activity.
What are the official names of this protein?
Grammistin Pp 3.
What is the protein family that this protein belongs to?
Belongs to the grammistin family. Group 3 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KHSE_PARP8
Sequence: MAVFTAVTEAQLADWMRHYDLGEVVEFRGITSGIENSNFFLTTTRGEYVLTIFEKLTAQQLPFYLDLMRHLASHRVPVPDPMPRDDGALFGMLNGKPATIVTKLDGAPELAPGAAHCVEVGQMLARLHLAGRDFAHHQPNLRSLPWWQETVPSIAPFLSDARRTLLTEELAHQQAFFASADYASLPGGPCHCDLFRDNVLFAHAAPGTHHEVELGGFFDFYFAGCDKWLFDVAVTVNDWCVDLATGKLDEARVEAMLRAYQTVRPFTPAEARHWGDMLRAGAYRFWVSRLYDFHMPRAAELLKPHDPGHFERILRERLAGAAL
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: MNME_SHEAM
Sequence: MTTDTIVAQATAPGRGGVGIIRVSGKLASDVAHTLLGHLPKPRYADFCDFKAADGSVIDQGIALFFKGPNSFTGEDVLELQGHGGQVVMDMLIRAVLKVKGVRIARPGEFSEQAFMNDKLDLTQAEAIADLIDATSEQAAKSALHSLQGEFSTQVHTLVDKITNLRLYVEAAIDFPDEEVDFLSDGKIAAALYAIIDQLDEVQASAKQGSIIREGMKVVIAGRPNAGKSSLLNALAGKESAIVTDIAGTTRDVLREHIHLDGMPLHIIDTAGLRDTTDEVERIGIERAWSEIASADRVLFMVDGTDTAAVDPHEIWPDFIDRLPKAMGVTVVRNKADLTGEPLEATEEQGYSVYRISAKTGLGVDALKQHLKSLMGYQSNLEGGFIARRRHLEALEQASEHLQLGKVQLEVYLAGELLAEELRMAQQALSEITGEFTSDDLLGKIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBJ_MAGTR
Sequence: MADTTGRIPLWLIGTVTGIPVIGSMGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PTFAX_XANCP
Sequence: MSSPSIAPVTPDLVRLRATARDKDDAIAQAAQLLVAAGCVAPGYDASMRRREGLANTFLGHGLAIPHGVGEDRHLVRRDGIAVLQLPEGVEWNPGQTTRLVVGIAAQSDTHITLLRRLTRLIQDPAQLEALFTTDDPAVIVAALTGDRAPDTSAAPATDLAERFEWTIAYPSGLHARPATRWAETARGFSARAQVRAGDQAADAKSLVGLLQLGLRAGDSITVSAKGSDAPALLKRLRAVMDSLTAQEKADAERAAQRRAAPVIGWTPPQAQPAIVGIGASPGVAIGIVHRLRAAQTEVADQPIGLGDGGVLLHDALTRTRQQLAAIQDDTQRRLGASDAAIFKAQAELLNDTDLITRTCQLMVEGHGVAWSWHQAVEQIASGLAALGNPVLAGRAADLRDVGRRVLAQLDPAAAGAGLTDLPEQPCILLAGDLSPSDTANLDTDCVLGLATAQGGPTSHTAILSRTLGLPALVAAGGQLLDIEDGVTAIIDGSSGRLYINPSELDLDAARTHIAEQQAIREREAAQRALPAETTDGHHIDIGANVNLPEQVAMALTQGAEGVGLMRTEFLFLERGSTPTEDEQYQTYLAMARALDGRPLIVRALDIGGDKQVAHLELPHEENPFLGVRGARLLLRRPDLLEPQLRALYRAAKDGARLSIMFPMITSVPELISLREICARIRAELDAPELPIGIMIEVPAAAAQADVLARHADFFSIGTNDLTQYVLAIDRQNPELAAEADSLHPAVLRMIRSTIDGARKHDRWVGVCGGLAGDPFGASLLAGLGVQELSMTPNDIPAVKARLRGRALSALQQLAEQALQCETAEQVRALEAQREGQA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II FruAB PTS system is involved in fructose transport.
What are the official names of this protein?
Multiphosphoryl transfer protein, MTP, Triphosphoryl transfer protein, TTP.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADHA_RHIME
Sequence: MTMTAAVVREFGKPLVIEEVPVPQPGPGQVLIKYEATGVCHTDLHAAKGDWPVRPNPPFIPGHEGVGYVAKLGAEVTRLKEGDRVGVPWLHTACGCCTPCRTGWETLCGSQQNTGYSVDGTFAQYGLADPDFVGRLPARLEFGPAAPVLCAGVTVYKGLKETEVRPGEWVLVSGIGGLGHMAVQYAKAMGMHVAAADIFPDKLALAEKLGADLVVDARAPDAVEEVQRRTGGLHGALVTAVSPKAMEQAYSMLRSKGTMALVGLPPGQICLPVFDTVLKRITVRGSIVGTRQDLEEALEFAGEGKVAAHFSWDKIENINAIFERMEEGKIDGRIVLDLNG
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: AHL4_ARATH
Sequence: MEEREGTNINNIPTSFGLKQHETPLPPPGYPPRSENPNLFPVGQSSTSSAAAAVKPSENVAPPFSLTMPVENSSSELKKKRGRPRKYNPDGSLAVTLSPMPISSSVPLTSEFGSRKRGRGRGRGRGRGRGRGQGQGSREPNNNNNDNNWLKNPQMFEFNNNTPTSGGGGPAEIVSPSFTPHVLTVNAGEDVTMKIMTFSQQGSRAICILSANGPISNVTLRQSMTSGGTLTYEGHFEILSLTGSFIPSESGGTRSRAGGMSVSLAGQDGRVFGGGLAGLFIAAGPVQVMVGSFIAGQEESQQQQQQIKKQRRERLGIPTTTQASNISFGGSAEDPKARYGLNKPVVIQPPPVSAPPVSFSHEPSTNTVHGYYANNTANHIKDLFSSLPGEDREEDEDDLEGEDDEEFGGHSESDTEVPS
What is the function of this protein?
Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity).  Acts redundantly with AHL3 to regulate the formation of tissue boundary between the xylem and procambium in the root meristem.  Cell-to-cell movement of AHL4 from the procambium to the xylem is critical for its function in root vascular patterning (PubMed:23335615).
What are the official names of this protein?
AT-hook motif nuclear-localized protein 4.
Protein: RL14_ACIBY
Sequence: MIQTETMLDVADNSGARRVQCIKVLGGSHRRYASVGDIIKVTVKEAIPRARVKKGDVMNAVVVRTKFGIRRPDGSVIRFDDNAAVILNNNKAPIATRIFGPVTRELRTEQFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: Y1503_LISMO
Sequence: MDSKDQTMFYNFGDDSIEEDVKKLMKQVYVALEEKGYNPVNQIVGYLLSGDPAYIPRHKDARSMIRRLERDEIIEELVKAYLKNNEIGEK
What are the official names of this protein?
UPF0297 protein lmo1503.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: DUT_PARUW
Sequence: MTQSYSNTLTIPTLIENEELLPFYMTPEAAGADVKAYLKESLEIPPGQSALIPTGMRLAIPEGYEIQVRPRSGLALKHQVTVLNTPGTIDADYRGEIKIILINHGTNAFIVEPGMRIAQLVLAQVLRANFVLSEELESTQRGVGGFGHTG
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: 4CL3_ORYSJ
Sequence: MGSVAAEEVVVFRSKLPDIEIDNSMTLQEYCFARMAEVGARPCLIDGQTGESYTYAEVESASRRAAAGLRRMGVGKGDVVMSLLRNCPEFAFSFLGAARLGAATTTANPFYTPHEVHRQAEAAGARVIVTEACAVEKVREFAAERGVPVVTVDGAFDGCVEFREVLAAEELDADADVHPDDVVALPYSSGTTGLPKGVMLTHRSLITSVAQQVDGENPNLYFSKDDVILCLLPLFHIYSLNSVLLAGLRAGSTIVIMRKFDLGALVDLVRKHNITIAPFVPPIVVEIAKSPRVTAEDLASIRMVMSGAAPMGKDLQDAFMAKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFKVKSGSCGTVVRNAELKIVDPDTGTSLGRNQSGEICIRGEQIMKGYLNDPEATKNTIDEDGWLHTGDIGFVDDDDEIFIVDRLKEIIKYKGFQVPPAELEALLITHPEIKDAAVVSMKDDLAGEVPVAFIVRTEGSEITEDEIKKFVAKEVVFYKRINKVFFTDSIPKNPSGKILRKDLRARLAAGIPDAVAAAAADAPKSS
What is the function of this protein?
Involved in the phenylpropanoid metabolism by mediating the activation of a number of hydroxycinnamates for the biosynthesis of monolignols and other phenolic secondary metabolites (PubMed:21807887, PubMed:23246835).  Catalyzes the formation of CoA esters of cinnamate, 4-coumarate, caffeate and ferulate (PubMed:21807887, PubMed:23246835).  Is more efficient with substrates in the following order: ferulate > 4-coumarate > caffeate > cinnamate (PubMed:21807887).  Possesses very high activity compared to 4CL1, 4CL2, 4CL4 and 4CL5 (PubMed:21807887).  Cannot convert sinapate to its corresponding CoA ester (PubMed:21807887, PubMed:23246835).  May play a role in the synthesis of lignin as well as other phenolic compounds (PubMed:21807887).  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester (By similarity).
What are the official names of this protein?
4-coumarate--CoA ligase 3, 4CL 3, Os4CL3, (E)-ferulate--CoA ligase, 4-coumaroyl-CoA synthase 3.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: MYP0_XENLA
Sequence: MEPSGLRTPCSLLALVLLSALVLTPTLAIEVYTDREVYGTAGSRVTLSCSFWSSEWISDDISVTWHYQPDHSREMYSIVHFAKGLSSIDAGIFKDRIEWVGSPKWKDASIVVHNLELTDNGTFTCDVKNPPDVVGKSSYVHLQVQEKGPARAGLILGIIIAVALALVIVVTILILLIRYCWLRRKARVQRELSALERGKLHKAKDSSKRSSRQTPILYAMLDQTRGKSSEKKAKGGIGDSRKDRK
What is the function of this protein?
Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
What are the official names of this protein?
Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero.
What is the protein family that this protein belongs to?
Belongs to the myelin P0 protein family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TTLL5_PONAB
Sequence: MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRGNPRRSLLTGRTRMTADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEEEEQEASQEESAGFLRENQAKYTPSLTALVENTPKEHSMKVREWNNKGGHCCKLETQELEPKFNLVQILQDNGNLSKVQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKSSKNNNSYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSTPFSGPTATLQKIPNTHLSSVTTSDLSPGPGHHSSLSQIPSAIPSMPHQPTVLLNTVSASASPCLHTGTQNIPNPAGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRPSSAKAAGSCYLNKHHSGIAKTQKEGEDASSYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQVTNLNLATGIINRSSASTPPTLRPIISPSGPTWSTQSDPQAPENHSSPPGSRSLQTGVFAWEGEVENNVYSKATGVVPQHKYHPTAGSYQLHFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKVVPPPSSCASLVPKPPPNHKQVLRRATSQRASKGSSAEGQLNGLQSSLNPAAFVPITSSTDPAHTKI
What is the function of this protein?
Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin.  Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step.  Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity).  Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules.  Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity).
What are the official names of this protein?
Tubulin polyglutamylase TTLL5, Tubulin--tyrosine ligase-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm. Note=Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid.
Protein: GGGPS_METPE
Sequence: MQNRWKDWVHVTKLDPDKSLPPAVIDEIATSGTDALMLSGTLNVTIENLGHLFKQVAQYGLPLVVEPAGPEAVLCEGIDLLFVPSVMNSNSVQWIVGKHQQWAQQSSIRWDKVIPEAYIVLNSSSSVGKVTGADCGLTPAEAAAYASVADHYFRFPIVYVEYSGMYGDPKMVRSIAEVVDRAILYYGGGISSADKAAEMGRWADTIVVGNAVYDLGPDVLRATVKAVQ
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UTR2_CANAL
Sequence: MRFSTLHFAFLATLSSIFTVVAASDTTTCSSSKHCPEDKPCCSQFGICGTGAYCLGGCDIRYSYNLTACMPMPRMSTFQESFDSKDKVKEIELQSDYLGNSTEADWVYTGWVDYYDNSLLIQMPNHTTGTVVSSTKYLWYGKVGATLKTSHDGGVVTAFILFSDVQDEIDYEFVGYNLTNPQSNYYSQGILNYNNSRNSSVNNTFEYYHNYEMDWTEDKIEWYIDGEKVRTLNKNDTWNETSNRYDYPQTPSRIQFSLWPGGDSSNAKGTIEWAGGLINWDSEDIKKYGYYYAHIKEIYATAYDIPNDVKLDGNSTKESDYHAFLYNSTDGDASNIMLTTKKTWLGSDDATGFDPQNDDEDSSSNKAQETTITSVSGSSTITSVKTDSTKKTANVPAQNTAAAAQATAKSSTGTNTYDPSAGVGGFVQDSKSTDSGSSGSSSQGVANSLNESVISGIFASICLGILSFFM
What is the function of this protein?
Extracellular glycosidase which plays an important role in fungal pathogenesis.  Involved in cell wall assembly and regeneration, filamentation, and adherence to host cells.  Plays a role of cell surface antigen in acute candidemia patients.
What are the official names of this protein?
Extracellular glycosidase UTR2, Cell-surface factor 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Covalently- linked GPI-modified cell wall protein (GPI-CWP).
Protein: GCH4_NITEU
Sequence: MNKQIDLPIADVQGSLDTRHIAIDRVGIKAIRHPVVVADKGGGSQHTVAQFNMYVNLPHNFKGTHMSRFVEILNSHEREISVESFEEILRSMVSRLESDSGHIEMAFPYFINKSAPVSGVKSLLDYEVTFIGEIKHGNQYSFTMKVIVPVTSLCPCSKKISDYGAHNQRSHVTISVRTNSFIWIEDIIRIAEEQASCELYGLLKRPDEKYVTERAYNNPKFVEDIVRDVAEVLNHDDRIDAYIVESENFESIHNHSAYALIERDKRIR
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: IF1_ACHLI
Sequence: MAREDLIEVEAKVKEILPNTKFIVELDNGHTVVAHVSGKIRIHNIRILPGDKVTVELSPYDLSRGRITYRKK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_XANOM
Sequence: MELVITGSNNKVSVSEAVFGREFSEDLVHQVVVAYRNAGRAGTKAQKTRSEVAGTTKKSKKQKGGGARHGALTAPIFVGGGVTFAAKPRSFEQKVNRKMYRAAICAIFSELNRQGRLMIVDAFDLEATKTKDLIEKLKGLDVGKRPLIVTEEASEHLYLSARNLPYVQVRDVQGLDPVALVGADTVVITADAVKKVEEWLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: HABP2_RAT
Sequence: MSVVMLVFRVLLLIALVGNSAIGLSLMPFIAPPDPDWTPDDYYYSYEQSSPDKDASVTQTSPENPDWYYEDDDPCQSNPCEHGGDCIIRGNTFSCSCPAPFSGSRCQTVQNKCKDNPCVQGDCLITQTPPYYRCACKYPYTGPDCSKVLPVCRPNPCQNGGVCSRHRRRSRFSCACPDQYKGRFCEIGPDDCYVGDGYSYRGKVSRTVNQNPCLYWNSHLLLQENYNMFMEDAETHGIADHNFCRNPDGDHKPWCFVKVNSEKVKWEYCNVEVCPESDAANPVGSLQEPVMELPGFDSCGKTEMTEHAVKRIYGGFKSTAGKHPWQVSLQTSLPLTTSMPQGHFCGGSLIHPCWVLTAAHCTDMSTKHLKVVLGDQDLKKTESHEQTFRVEKILKYSQYNERDEIPHNDIALLKLKPVGGHCALESKYVKTVCLPSDPFPSGTECHISGWGVTETGEGSRQLLDAKVKLIANALCNSRQLYDHTIDDSMICAGNLQKPGSDTCQGDSGGPLTCEKDGTYYVYGIVSWGQECGKKPGVYTQVTKFLNWIKTTMHKEAGL
What is the function of this protein?
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly.  It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form.  Activates coagulation factor VII (By similarity).
What are the official names of this protein?
Hyaluronan-binding protein 2, Plasma hyaluronan-binding protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Protein: HUNB_DROIK
Sequence: WYSSMFAANIKQEPISHHHHHHHAHHSHHQHSHDSNSNSNASSPHQSPLPSPNPPSSNNLQLEQYLKQQQQQQQQQQPMDTLCAGAMTPSPSNNDQNSRLRPPGLPNPMQTIMPANMRPSPTATTTATTTAAAASTTTAATVALQSNDKLQALTPPMDVTPPKSPAKSQQSCAEPEKEHDLMSNSSEDMKYMA
What is the function of this protein?
Gap class segmentation protein that controls development of head structures.
What are the official names of this protein?
Protein hunchback.
What is the protein family that this protein belongs to?
Belongs to the hunchback C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.