PharMolix/UniProtQA huggingface dataset:
Protein: VE7_HPV44
Sequence: MHGNYTTLKEIVLQLEPPDPVGLHCNEQLDSSEDEVDELATQATQDVTQPYQIVTTCGTCSRKVRLVVQCTGTDIHHLHTLLLGSLDILCPVCAPKT
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: GLPE_YERPS
Sequence: MEQFEAISVEQAYLRWKEGKTALVDIRDPQSYEAGHAPGAFHLTNSSLHTFMQQTDFDQPVMVMCYHGNSSKGAAQYLLQQGFDVVYSIDGGFEAWARSYPQDITSESR
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_PSEP1
Sequence: MKSYLDLLTDVLENGSVKGDRTGTGTISVFGRQYRHDLSKGFPLLTTKKLHFKSIVNELIWFLSGDTNIKWLNENGVKIWNEWATEEGDLGPVYGKQWTAWPTKDGGTINQIDYVVNALKTNPNSRRILFHGWNVEYLPDEKVSPQENAENGKMALPPCHLLYQFYVVDNKLSAHLFIRSSDSFLGLPYNTASLACLTHMLAQQCDMGVGEIVISLSDVHIYSNHMEQVKTQISREPRKLPELKLLRKPESIYDYKFEDFELVGYDPHPHIAAPVSI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH4_BURCM
Sequence: MNQMNPAFVMPDVQSTVDTRQIPIQRVGVKAVRHPLTVRTESGDVQPTVGVWNLDVHLPADQKGTHMSRFVALLEDSREPLTVERFRAMLASMLVRLEAEAGRIEVTFPYFVNKTAPVSGVQSLLDYEVTLAGESRNGETRLFLKVLVPVTSLCPCSKKISQYGAHNQRSHVTIDAELAADLPVEALIRIAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDVAQRLDADERVVAYVLEAENFESIHNHSAYALIERDKRHAA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: PYRB_CAMJD
Sequence: MRHLITTKDFNKIEIMELFKEASDFLDEKPRTFLEGKSITTIFFENSTRTLSSFESAARRLGARVLRLDVSRSSSSKGETLYDTAANLDAMSPNAIVVRHANSGVPLILAKHMHCPVVNGGDGKHAHPTQALLDLFTIYNHFQSDVEGKKICIVGDIKNSRVAASNIELLSRFNLDITLVAPPHFMPNTHLKKYYKLDENIIANSDIIMSLRTQTERHNKTVYASLKDYANDFCIQKSLVKDKKLILLHPGPVNRNIDISDEMMSDERTLVLKQVKNGVAIRMAVLKKLILENEG
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: DIVK_BRUSI
Sequence: MTKSVMIVEDNELNMKLFRDLIEASGYETIRTRSGLEALDLAREHHPDLILMDIQLPEVSGLEVTKWLKDDEELRHIPVIAVTAFAMKGDEERIRQGGCEAYISKPISVPRFIETIKSYLGDA
What is the function of this protein?
Essential protein that is involved in the control of cell division, probably through the regulation of ctrA.  Its phosphorylation status is regulated by PdhS (By similarity).
What are the official names of this protein?
Polar-differentiation response regulator DivK.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized at one pole of the cell. Colocalizes with PdhS (By similarity).
Protein: RIMM_CHLCH
Sequence: MELFLTGKILKPRGLKGEVKVELITDFPHHFVKRKQFFVGVSPSSVVCMQVTKAALHGGFAWLFFEGIDTFEQATTLVGFSLFITEEELAPQPENHVYRHEIVGMRVVDGNGKLFGTVTDIFNMPAHDVYEVQVEGKTVLLPAIEAFVESFELASKTIVMSRCWEFL
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP4R3_XENLA
Sequence: MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINTNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAEVVASSLPSPLRREKLAVALENEGYLKKLLELFHVCEDLENIEGLHHLYEVIKGIFLLNRTALFEVMFSEDCMMDIIGCLEYDPSLPTQRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDVVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQEDEKFLTELFAHLTDEATDDEKRQELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILGMDDPQVRSAATDIFSYLVEYNPSMVREFVMQEAQQNDDDILLINLIIEHMICDTDPELGGAVQLTGLLRTLVDPENMLATTNKTEKTEFLGFFYKHCMHVLTAPLLANTTEEKPSKDDFQAAQLLALILELLTFCVEHHTYHIKNYIINKDILRRVLVLMSSMHSFLGLCALRFMRKIVGLKDEFYNRYIVKSFLFEPVVKAFLNNGSRYNLMNSAILEIFEYIRVEDIKSLTAHVVENYWKALEDVEYVQTFKGLKLRYDQQRERQDNPKLDSMRSILRNHRYRRDARSIEDEEEMWFNTDEDDLEDGEPVVLPSEKIKNSEDLMDPISKFMERKKLKESEEKEVLLKTNLTGRQSPNFKLSFSGATKTNLTSQLSASGHPGSPGSPGSPGSPESPGSVSKSTPQAAAITTKGGLIGLVDYPDDDEEDDDNDEEEKEERLPLTKKARLGS
What is the function of this protein?
Regulatory subunit of serine/threonine-protein phosphatase 4.
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit 3, SMEK homolog 1.
What is the protein family that this protein belongs to?
Belongs to the SMEK family.
Protein: MIAB_NEIMF
Sequence: MKKVFIRTFGCQMNEYDSDKMLAVLAEEHGGIEQVTQADEADIILFNTCSVREKAQEKVFSDLGRVRPLKEKNPGLIIGVAGCVASQEGENIIKRAPYVDVVFGPQTLHRLPKMIVDKETSGLSQVDISFPEIEKFDHLPPARVEGGAAFVSIMEGCSKYCSFCVVPYTRGEEFSRPLNDVLTEIANLAQQGVKEINLLGQNVNAYRGEMDDGEICDFATLLRIVHEIPGIERMRFTTSHPREFTDSIIECYRDLPKLVSHLHLPIQSGSDRVLSAMKRGYTALEYKSIIRKLRAIRPDLCLSSDFIVGFPGETEREFEQTLKLVKDIAFDLSFVFIYSPRPGTPAANLHDDTPHEEKVRRLEALNEVIEAETARINQTMIGTVQRCLVEGISKKDPDQLQARTANNRVVNFTGTPDMINQMIDLEITEAYTFSLRGKVVEA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_EDWI9
Sequence: MKRTFQPSVLKRNRTHGFRARMANKNGRQVLARRRAKGRARLTVAG
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: SYP_MESH2
Sequence: MKKPEKITSRTANFAKWYVDVITQADLMNYGPIKGTIYFKPLGYKIWENIVKIVNAYFVKQKIENVYFPLLIPQDFIEKEKKHIEGFAPELLTITKVGDKNLVENIYIRPTSELLFADYFKAEIAKNNILPIKLNQWSQVLRWEKTTNPFLRNTEFLWQEGHTIHASKVEADQFAKKIARFYKYFLENYLAIPVISGQKTEREKFAGAVNTYTVEAMMQNFRALQSATAHFLGQNFAKNFEIFYKNKENKSQIPFQTSWGLSTRLIGAIVMVHSDDNGLIFPPKIAPIQVDILEFFSKKNQEVKIFAKKIAKILKNAKISYKIDDTDQQIGYKINNSEVHGAPIRIEIGPNEVKNNQICLVRRDNHQKFFFNIDLLKEKCRKILEQIQADLFKKAKIRLLENTVFVNSINEFEHAVKNNKFVIAPFSESPEREQEIQEKTGATARCILPKNSFFALPQTGNSIFSGEKTNKFVLFAKSY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRIZ2_ARATH
Sequence: MNSASVSGESSLSDMIQTVHFSSGNPRIGETRGVMHLISDNAVSSSSSSSSSNLPIGRNPLVCVLGVPNHMTYADFCQFCGSFIQHILDMRTVRNDDIENRYSILIRFDSQESTDTFFQHFRGKQFNSLDEDVCRLLFALDVQFTGYSGSIDHTQPSAAGPIEQPTCPVCLERLDQDTGGILTTMCNHSFHCSCISNWPDSSCPVCRYCQQQPENSVCCVCQTTENLWMCVICGVVGCGRYKEGHARRHWEETEHCYSLELETQRVWDYAGDNYVHRLIQSKTDGKLVELNSHGSLSKDGCGSCEYSDSGMTDALLNSKVDMIISEYNELLQAQLENQKQYFEKLLQNVKEETEQKISEAASKAISQRLQKLQTRFDRCVKEKQFLEDLNENLVKNKDVWSTKITEMKEREKKAVRAKDEKIQGLEEQLGNLMAQMDGESEVSETKEVQDATVSTTNTSSSGAGNVIHANKKKSNRRKG
What is the function of this protein?
RING-type ubiquitin E3 ligase that binds ubiquitin and is required for seed germination and post-germination growth.
What are the official names of this protein?
BRAP2 RING ZnF UBP domain-containing protein 2.
Protein: HRCA_BURM1
Sequence: MLDPRARTLLKTLIERYIADGQPVGSRTLSRYSGLELSPATIRNVMSDLEELGLVSSPHTSAGRVPTPRGYRLFVDTMLTVETPIDAAAVARQVQSTLQAGEPQQKVVAAAASVLSNLSQFAGVVLTPRRSHVFKQIEFMRLSEKRILLIIVTPEGDVQNRMLATPRDYSPSQLTEASNYINAHFAGLSFDEVRRRLRDEIDQLRGDMTALMHAAVTASTEVPDTEDTVLISGERNLLEVADLSSDMARLRKLFDVFDQKTGLLQLLDVSSHAQGVQIFIGGESTLVPIEEMSVVTAPYEVNGKIVGTLGVIGPTRMAYNRVIPIVDITARLLSLTLSQQ
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: SSTT_VIBVY
Sequence: MQHNSLIARFARGNLVIQILVGIILGISLALVSPSSAESVGMLGSLFVGALKAIAPILVFILVAASIANQKKNQHTHMRPIIVMYLAGTFFAALTAVVLSFMFPTTLTLVTGAEGANPPQGIMEVIKTLLFKLVDNPVNALMSANYIGILAWGVGLGLALHHASDTTKAVFEDLSHSVSHIVRFIIRLAPFGIFGLVASTFATTGFDALAGYAHLLVVLLSAMAIIALIVNPAMVYVKTKQNPYPLVFQCLRESGVTAFFTRSSAANIPVNMALCEKLKLDEDTYSVSIPLGATINMAGAAITITTLTLAAVHTMGIEVDLMTALLLSVVAAVSACGASGVAGGSLLLIPLACGLFGISNDIAMQVVAVGFIIGVIQDSAETALNSSTDVVFTAAVCESEAQKAKG
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYF_SACHY
Sequence: MENRKTFSWLKEQMIRSISVSIMIYVITRTSISNAYPIFAQQGYENPREATGRIVCANCHLANKPVDIEVPQAVLPDTVFEAVLRIPYDMQLKQVLANGKKGGLNVGAVLILPEGFELAPPDRISPELKEKIGNLSFQSYRPNKKNILVIGPVPGKKYSEIVFPILSPDPATKKDVHFLKYPIYVGGNRGRGQIYPDGTKSNNTVYNATSTGIVKKILRKEKGGYEISIVDASDGRQVIDIIPPGPELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFFASVILAQVFLVLKKKQFEKVQLYEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FX4L6_HUMAN
Sequence: MNLPRAERLRSTPQRSLRDSDGEDGKIDVLGEEEDEDEVEDEEEAASQQFLEQSLQPGLQVARWGGVALPREHIEGGGGPSDPSEFGTKFRAPPRSAAASEDARQPAKPPYSYIALITMAILQNPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHLPHPFPLPAAHAALHNPHPGPLLGAPAPPQPVPGAYPNTAPGRRPYALLHPHPLRYLLLSAPVYAGAPKKAEGAALATPAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVLCKGSGERVQGLRRVCPRPRGATATCSSDHQACCIPRPLPLCCKCPPPPLLGQFCSNSSSIRRRTAPTAALPPRARCWAGTCRPRRPC
What are the official names of this protein?
Forkhead box protein D4-like 6, FOXD4-like 6.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS7_ECO81
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYSALETLAQRSGKSELEAFEVALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAAENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RNPA_BACC1
Sequence: MKKKHRIKKNDEFQTVFQKGKSNANRQFVVYQLDKEEQPNFRIGLSVSKKIGNAVVRNRIKRMIRQSITELKDEIDSGKDFVIIARKPCAEMTYEELKKSLIHVFKRSGMKRIKK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: WALK_STAAW
Sequence: MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLLSEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKVIGNIYIESKINDVYNQLNNINQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAKEDIIGYYMLSVLSLEDEFKLEEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGAWKDEELAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKKTIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIEDGDWDE
What is the function of this protein?
Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins.  Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR.  In turn, WalR binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression.
What are the official names of this protein?
Sensor protein kinase WalK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CDA2_YEAST
Sequence: MRIQLNTIDLQCIIALSCLGQFVHAEANREDLKQIDFQFPVLERAATKTPFPDWLSAFTGLKEWPGLDPPYIPLDFIDFSQIPDYKEYDQNHCDSVPRDSCSFDCHHCTEHDDVYTCSKLSQTFDDGPSASTTKLLDRLKHNSTFFNLGVNIVQHPDIYQRMQKEGHLIGSHTWSHVYLPNVSNEKIIAQIEWSIWAMNATGNHTPKWFRPPYGGIDNRVRAITRQFGLQAVLWDHDTFDWSLLLNDSVITEQEILQNVINWNKSGTGLILEHDSTEKTVDLAIKINKLIGDDQSTVSHCVGGIDYIKEFLS
What is the function of this protein?
Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate (PubMed:9133736, PubMed:11812231).  Chitosan is a component of the spore wall (PubMed:9133736).
What are the official names of this protein?
Chitin deacetylase 2.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family.
What are the subcellular locations of this protein?
Prospore.
Protein: CALR_RABIT
Sequence: MLLPVPLLLGLLGLAAAEPVVYFKEQFLDGDGWTERWIESKHKSDFGKFVLSSGKFYGDQEKDKGLQTSQDARFYALSARFEPFSNKGQPLVVQFTVKHEQNIDCGGGYVKLFPAGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKTAEKQMKDKQDEEQRLKEEEEEKKRKEEEEAEEDEEDKDDKEDEDEDEEDKDEEEEEAAAGQAKDEL
What is the function of this protein?
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle (PubMed:10581245).  This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER.  Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity).  Involved in maternal gene expression regulation.  May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).  Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).
What are the official names of this protein?
Calreticulin, CRP55, Calregulin, Endoplasmic reticulum resident protein 60, ERp60, HACBP.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Cytolytic granule. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity).
Protein: MNMA_STAAT
Sequence: MSNKDIRVVVGMSGGVDSSVTAHVLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEKEYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLDHAMNLGADYVATGHYARIHRHEDGHVEMLRGVDNNKDQTYFLNQLSQQQLSKVMFPIGDIEKSEVRRIAEEQGLVTAKKKDSTGICFIGEKNFKTFLSQYLPAQPGDMITLDGKKMGKHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLKDNVLYVEQGFHHDALYSDYLIASDYSFVNPEDNDLDQGFECTAKFRYRQKDTKVFVKRENDHALRVTFAEPVRAITPGQAVVFYQGDVCLGGATIDDVFKNEGQLNYVV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_HYDCU
Sequence: MTDQKLVTVIDYGMGNLRSVAKAAEHAADSNTRICISDKAEDIRSADAIIFPGQGAAKACMKALNETNITHALIQAATEKPFLGICMGLQVLMTHSQENEGVDCLDILKGDVQKFDLSGHPELKMPHMGWNQIHQTIDHPLWHNIEQNSRFYFVHSYFVSPHDKQIIAGETTHGKRFTSAIAQNNLFAIQAHPEKSADAGLQLFKNFLNWNGQ
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATB_HALLT
Sequence: MKEYQTITEISGPLVYAEVDEAIGYDEIVEIETAQGETLRGQVLESSEGVVAIQVFEGTSGIDQNASVRFLGETMKMPVTEDLLGRVLDGSGRPIDDGPEIVPEERQDIVGAAINPYSREYPEEFIETGVSAIDGMNTLVRGQKLPIFSSSGQPHSQLAMQIARQASVPEEEEGGDDEEGSEFAVIFGAMGITAEEANEFMQDFERTGALERSVVFMNLADDPAVERTVTPRMVLTTAEYLAFEKDYHVLVILTDMTNYCEALREIGAAREEVPGRRGYPGYMYTDLAQLYERAGRIQGRDGSVTQIPILTMPGDDDTHPIPDLTGYITEGQIYVDPDLNSQGLQPPINVLPSLSRLMDDGIGEGLTREDHADVKDQMFAAYAEGEDLRDLVNIVGREALSELDNKYLDFADDFESEFVDQGFDQNRSIEETLEIGWDLLSMLPKDALNRIDEEFIEKYYREDDSDRQVVEAAD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: AKTP2_DROSI
Sequence: MWYTTVRNPSIALIKQGYHILAEYNLVKEELKNIYAIPSYACGLHWFGVIFVHSGIYAGSVFRFSILLPDNFPVDISLPTVVFSTAVLHPHICPQNKTLDLAHFLNEWRKDEHHIWHPYCAERHLKFMDQLKSPCWKEATSMDCSQPSQYLGHIDSSRQLDEEEANQVVKLHCGRVPEPQREAAEVSL
What are the official names of this protein?
Protein crossbronx-like.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
Protein: HERC4_MOUSE
Sequence: MLCWGNASYGQLGLGGIDEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWFSYNGQCPQDIGSEDYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCSDPSKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAISNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDCNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKTGQLIQYDKFYIHEVQELIDIRNDYINWVQQQAYGVDVSHGVTELADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI
What is the function of this protein?
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures.  Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon.  E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase HERC4, HECT domain and RCC1-like domain-containing protein 4, HECT-type E3 ubiquitin transferase HERC4.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: APAG_PSEA8
Sequence: MSDTQHQVNVRVDTRYLPEQSAPEQNRFAFAYTVTIENQGEVPAQLLSRHWIITDGDGRTQEVRGAGVVGEQPLIAPGAQHTYTSGTVLATRVGSMRGSYQMLGSDGIAFDAAIPVFRLAVPGALH
What are the official names of this protein?
Protein ApaG.