PharMolix/UniProtQA huggingface dataset:
Protein: TUSD_SHIB3
Sequence: MRFAIVVTGPAYGTQQASSAFQFAQALIVEGHELSSVFFYRGGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGIVDETEAGRLGLASSNLQPGFTLSGLGALAEASLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_EHRCR
Sequence: MNIHEYQAKHILSKFGVNVPKGVVVHSLGEVDGALSQLNSKVVVVKAQIHAGGRGKAGGVVVSRTLDETKTSIKNMLGSTLITHQTSKDGQKVRKVYLEEGCNIKKEYYISAIVNRKQGQVSIIFSTEGGVDIEEVAATSPEKVIVCNINPVFGFQGFHGRNLCFDSNLSLDQTRKISDIAGKIYKAVLSTDANQIEINPLVETSSGEFIALDAKINFDDNALYRHPDIQELRDYDEEIKEEIEASKHGLSYIKMDGNIGCMVNGAGLAMATMDIIKYYGAEPANFLDVGGGASQKTVTEAFKIILADDKVNGILVNIFGGIMRCDIIANGIIAAIQEIGINVPLVVRLSGTNFELGKKLLDDSNLNIITANDLSEAAYNIVNIVRK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: KDUI_PECCC
Sequence: MDVRQSVHSEHAKTLDTTELRKKFLIEQIFTPNQYTMTYSHIDRIVVGGIMPVDGEITFDDGIGKQFGVNYFLERRELGLINIGGPAKIVIDGTSYEVGNEEALYVGKGAKALAFSSLDSAKPAKLYYNSAPAHAVFPTRIITQDDAIKAPLGDVKTCNKRTICKYLVPEVVETCQLSMGLTRLAEGSNWNSMPTHTHERRMEVYFYFDMAEDTIIFHMMGEPHETRHLVMHNEQAVISPSWSIHTGVGTKNYAFIWGMIGENLTFDDMDHIAMLDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: RS12_CAMC1
Sequence: MPTINQLVRNERKKVTVKSKSPALKECPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTSGFEVISYIGGEGHNLQEHSIVLVRGGRVKDLPGVKYHIVRGALDTAGVAKRTVSRSKYGAKRPKAGAAAPKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: DNAA_MACCJ
Sequence: MSGIDTIWEKVLANIKHRLAPASYDTWFKETKIKVLNNHQVVIQAPTSFISEWLQTNYIDFIQEAFIEEIGEKLNIKVISSEDELMNNEKEAPVRKTQQTSQELLPNQLNTDNTFDTFVIGSGNRFSHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVMEHKENAKVVYISSEKFMNEFINSIKDNKTEEFRSKYRNVDVLLIDDIQFLAGKESTQEEFFHTFNELHQNHKQIVISSDRAPKEIPTLEERLRTRFEWGLITDVTPPDLETRIAILRKKSEEENIDIPNEAMLYIATQIQSNIRELEGALTRVSAYSKLVNRELNSDLVAEALKDIIATSKPKKVTIKDIQLAVGEYYNVRLEDFSAKKRTKSIAFPRQIAMYLARELTDFSLPKIGEEFGGRDHTTVIHAHEKIKNQLETDESLKNELKNIEKDITS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_ERWT9
Sequence: MAKKFTQHRGIVLPLDAANVDTDAIIPKQFLQMVTRTGFGRNLFYDWRYLDAEGQLANPDFVLNKPEFSGASIMLTRENFGCGSSREHAPWALTDYGIQAIIGSGFADIFANNAFNNQLLLVTLSEQQVDELFQQVAAQPGIGFTVDLESQQVQAGDNIYPFAIDPFRRHCLLNGLDAIGLTLQHDADISAWERQQPSFLR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RUVA_CLOPE
Sequence: MYEYIRGQFQGISKDYVVIELNNIGYKIFTSGNTMSNMPKVGDEVLLYLEQIVREDFIGLYGFTTREELEMFKLLLSINGVGAKAALSLLSISTVNNLKYAIMMGDEKHITRAPGIGKKTAQRIILELKDKLKPDELTSEEGQLIEGINDNSDYSFNINETLSALMALGYTEKEAQKALEKVDKTLSIENMIKESLKLLMR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: LPPRC_RAT
Sequence: MSALLRPARWLLGAAAVPRLPLSLRLPAGGPGRLPSVVRVAAAGGRPAAGELLSQARLYAIVAEKKDLPEEPAPVRRSGSQFDWALMRLDNSVRRTGRITKGLLQKVFESTCRSGSPGSNQALLLLRSCGSLLPELSLAERTEFAHKIWDKLQQLGTVYDVSHYNALLKVYLQNEYRFSPTDFLAKMEGANIQPNRVTYQRLIAAYCSVGDIEGASKILGFMKTRDLPITEAVFSALVTGHARAGDMESAENILTVMKQAGIEPGPDTYLALLNAHAEKGDIDHVKQILEKVEKSDHYFMDRDFLQIIVSFSKAGYPQYVSEILEKITYERRSIPDAMNLILLLVTEKLEDTAFQVLLALPLARDETSSSFGSFFLRHCVTMDTPAEKLIDYCKRLRDAKVHSSSLQFTLHCALQANKTALAKAVMEALRDEGFPIRTHYFWPLLVGHQKTKNVQGIIDILKIMKEMGVDPDQETYINYVFPCFGSVQSARAALQENKCLPKSTTFAQAEVRNEAINGNLQNILSFLESNALPFSFNSLRGSLILGFRRSMNIDLWSKITELLYKDDRYCQKPPGPTEAVGYFLYNLIDSMSDSEVQAKEERLRQYFHQLREMNVKVSENIYKGICNLLDNYHVPELIKDVKVLVDREKIDSRKTSQFTSSDLESTLEKLKAEGHPVGDPLKQLILLLCSEENMQKALEVKAKYESDMVIGGYAALINLCCRHDNAEDALNLKQEFDRLDPSAVLDTAKYVALVKVLGKHGRVQDAINILKEMKEKDVVIKDAAVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHLEKDDLPAALEASIACHEKYKVLPRIHDVLCKLIEKGETDLIQKAMDFVSQEQGEMSMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTEKLFECDRDQMYYNLLKLYKISGDWQRADAVWNKMQEENLIPRERTLRLLAGILKTSNQEVPFDVPELWFGDDRSSLSSSSPSAGDTVTEKMLLSDCRLKKSKDAYNIFLKAEKQDVVFSSEAYSTLVGLLLSKDDFTRAMHVKDFAETHIKGFTLNGAASSLLIIAQVRRDYLKVALETLKAALDLEQVPSELAVTRLIQALALQGDVKSIETIQKMVKGLDAIELSRMVFINNIALAQMKNNEIDAAIENIEHMLASENQTVEHQYFGLSYLFRKVIEEQMEPALEKLSIMSERLANQFALYKPVTDLFLQLVDSGKVDEARALLERCGAIAEQTSILSVFCLRTSQKPKKAPVLKTLLELIPELRENDRVYSCSMKSYVADKDVASAKALYEHLTAKNMKLDDLFLKRYASLLKDVGEPVPFTEPPESFGFYIKQLKEARENPS
What is the function of this protein?
May play a role in RNA metabolism in both nuclei and mitochondria.  In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export.  May bind mature mRNA in the nucleus outer membrane.  In mitochondria binds to poly(A) mRNA.  Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits.  May be involved in transcription regulation.  Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors.  Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP.  Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters.  Binds single-stranded DNA (By similarity).
What are the official names of this protein?
Leucine-rich PPR motif-containing protein, mitochondrial, 130 kDa leucine-rich protein, LRP 130, Leucine rich protein 157, rLRP157.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane.
Protein: ANKR2_HUMAN
Sequence: MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRGDARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
What is the function of this protein?
Functions as a negative regulator of myocyte differentiation.  May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.
What are the official names of this protein?
Ankyrin repeat domain-containing protein 2, Skeletal muscle ankyrin repeat protein, hArpp.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
Protein: CYB_XERTE
Sequence: MTNTRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGLCLAIQILTGLFLAMHYTPDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTYFETWNIGVILLFAIMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALVMVHLLFLHETGSNNPSGLVSDSDKIPFHPYYTIKDALGILFLITALMTLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILTLFPLLHLSKQRSMMFRPLSQCIFWILVADLFTLTWIGGQPVEYPFITIGQLASVLYFSIILLILPAASLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CPR5_ARATH
Sequence: MEALLLPPSPEPQNQITNPANSKPNHQSGDVHKDETMMMKKKKDTNPSNLEKRKLKGKKKEIMDNDEASSSYCSTSSTSNSNSTKRVTRVVHRLRNPMRLGMARRSVGERQAEKLAKPLGFSLAAFANMVIARKNAAGQNVYVDDLVEIFATLVEESLANVYGNKLGSFATNFEQTFSSTLKILKLTNECANPHQSNNNDGGSCNLDRSTIDGCSDTELFERETSSATSAYEVMQGSATATSLMNELALFEETLQLSCVPPRSSAMALTTDERFLKEQTRANDLKTVEIGLQIRELRCKETALGLKFESNNLGKAALELDVSKAAFRAEKFKTELEDTRKEEMVTRIMDWLLVSVFSMLASMVLGVYNFSIKRIEDATSVCDQSEEKSSSWWVPKQVSSINSGFNTFICRVRVWVQIFFGVLMIIVFTYFLNKRSSGTKQTMPISFIVLFLGIFCGVSGKLCVDTLGGDGKLWLIVWEVFCLLQFVANVFTLALYGLMFGPINVTQETRSNRCNSMFPYWARRSVVYVVILFVLPVINGLLPFATFGEWRDFAMYHLHGGSDYA
What is the function of this protein?
May play a role in transcriptional processes (PubMed:21875893).  Regulates negatively the senescence and chlorotic lesions induced by biotic (e. g.  pathogens) and abiotic (e. g.  sugars, darkness) agents, probably by controlling programmed cell death (pcd) (PubMed:11846876, PubMed:9338960, Ref. 6, PubMed:11728314).  Negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI) (PubMed:25455564).  Promotes cell division and endoreduplication (e. g.  in trichomes) (PubMed:11728314).
What are the official names of this protein?
Protein CPR-5, Protein constitutive expression of pathogenesis-related genes 5, Protein constitutive expression of PR genes 5, Protein hypersenescence-1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Nucleus membrane.
Protein: Y194_AQUAE
Sequence: MEFFFFIDVYADRELVDYYIVTFKLDDLSSVELTGSQGKYYIRGIRDWEKFKEEAYDITLYELGDEVDRFKDIETALREAYRIAIGEAVRRGAKNIVPAIGFGNPPPEVVERVYPEELKFEKFPEDLDAFLDRIVKEVSLETTERSKDDDEIPF
What are the official names of this protein?
Uncharacterized protein aq_194.
Protein: KLH20_MOUSE
Sequence: MRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCESHIW
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport.  The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis.  The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination.  Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking.  Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases.  The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity).
What are the official names of this protein?
Kelch-like protein 20, Kelch-like ECT2-interacting protein.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon. Cell projection, dendrite. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination (By similarity).
Protein: HIGA3_MYCTU
Sequence: MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIVAEFGENTVELTA
What is the function of this protein?
Putative antitoxin component of a type II toxin-antitoxin (TA) system.  Its cognate toxin would be HigB3.
What are the official names of this protein?
Putative antitoxin HigA3.
Protein: CYB_NEOAL
Sequence: MTNIRKNHPLXKIMNESFIDLPAPSNISSWWNFGSLLGVCLVIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYTFMETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFMLPFIITAMVVVHLLFLHETGSNNPTGIDSDSDKIPFHPYYTIKDFLGIILLLTALMTLVLFFPDILGDPDNYTPANPLSTPAHIKPEWYFLFAYAILRSIPNKLGGVLALIASILILALMPTLHTSKQRGLMFRPISQTLFWILVANLLILTWIGGQPVEYPFITIGQLASISYFTIILILMPTAGIIENNMLKFTH
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SYN_MYCPN
Sequence: MSATAISDLFEKPAQFKNKKIKLTGWLKNKRTSANIIFLEVNDGSTLLNLQAVVKQDQPELFALAESISLASAVSVSGTVALTPKSKQPLELVVKQINVLSTARADYPLQKKEHSLEFFRNNAYLRVRARTYFAIMKVRSLLSQAIFDYFFKNDFVLVHSPILTSNDCEGAGETFELKQGKEFFNKTTYLTVSGQFGAECYAQAFKKVFTFGPTFRAEKSHTSRHLSEFWMIEPEVAFANLKDLIKLIESTVKTVIKQVMQKAKQELDFLEKQFDVKLMERLKQITSTKNFHVLEYTKALEILKTAQASGQANFEVQDFNFGLDLKTEHERFLCEQHFHNQPVFVINYPKDFKAFYMKQNADGRTVGAVDLLFPQIGEICGGSEREGNLEKLVERCQAMQIDTQTLNWYLDMRKWGYFASAGFGLGFDRLLAYICGLENIRDAIPFPRAHGSINY
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTU1_PICST
Sequence: MTEISAKKVKVSALCELCHARKAVMKRPKNLQKLCKDCFYKVFETEIHNTIVDAKLFSPGDKVAIGASGGKDSTVLASVLKTLNERYDYGLILVLLSIDEGIKGYRDDSLATVKRNQVQYEMPLEIISYRDLYNWTMDEIVSCAGIRSSCTYCGVLRRQALDRGAAKLGINHVVTGHNADDMAETVLMNLLRGDTARLEKSCAIITQSAGSPIKRSKPFKYTYQKEIVLYAHYKKLDYFSTECTYAPEAFRGTARELLKSLESIRPSCIMDIIYSGEHLVLAPKKKKITTSYKTNKKKTHTENEVNADGSVSLGRKKQFEDGNRCEKCGYLSSNRICKACMLLAGLEMNRAKVSIDNNTAVDGAAVLTRTLEQLSF
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.  It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 1, Cytoplasmic tRNA adenylyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMB_SALTY
Sequence: MDKIFVDEAVSELHTIQDMLRWAVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRINERIPVAYLTNKAWFCGHEFYVDERVLVPRSPIGELINNHFAGLISQQPKYILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEHNIEEHGLIHHVTPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAPDYLSDDGVLICEVGNSMVHLMEQYPDVPFTWLEFDNGGDGVFMLTKAQLLAAREHFNIYKD
What is the function of this protein?
Specifically methylates the 50S ribosomal protein L3 on 'Gln-150'.
What are the official names of this protein?
50S ribosomal protein L3 glutamine methyltransferase, L3 MTase, N5-glutamine methyltransferase PrmB.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
Protein: PGK_STRGC
Sequence: MAKLTVKDVDLKGKKVLVRVDFNVPVKDGVITNDNRITAALPTIKYILEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVKFIPGVTRGAELEAAINALEDGQVLLVENTRFEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVEAPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAFADYTEVKDTEGEAVDPGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COPA_STAAB
Sequence: MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPDQHDVQEFINTIQHLGYGVAVETVELDITGMTCAACSSRIEKVLNKMDGVQNATVNLTTEQAKVDYYPEETDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISAVLSLPLLMLMFVHLFNMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSIYEMIRWLNGSTTQPHLYFETSAVLITLILFGKYLEARAKSQTTNALGELLSLQAKEARILKDGNELMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTVIGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIALLTFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGGEFVERTHQIDTIVLDKTGTITNGRPVVTDYHGDDQTLQLLATAEKDSEHPLAEAIVNYAKEKQLTLTETTTFKAVPGHGIEATIDHHHILVGNRKLMADNDISLPKHISDDLTHYERDGKTAMLIAVNYSLTGIIAVADTLKNHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGIDTVIADILPEEKAAQIAKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAAGITILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSSVSVVTNALRLKKMRLEPRRKDA
What is the function of this protein?
Involved in copper export.
What are the official names of this protein?
Copper-exporting P-type ATPase, Copper-exporting P-type ATPase A, Cu(+)-exporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UL13_EHV1V
Sequence: MARSRRRSSVDEMDVGGSATSEYENCGGPSFSPLNLSRPKKSTRGRSLRSAQAWGGKQLHPERSTPLARNDCGPSSKPRRRHEVGRSNKGLGASLDRTDEDTSQCPRIRASAIRCGASTRKIVRITGECDAQQGDSRPGRSEMAGWHSPPKRRRTPSRHGNSDNERSHLPRLSSHGVVRVGGRPLTQTPLQKTIILQPKLVRKVFMPTFTVNPEMHYRRVALGEIPKFGGAGSYGEVQIFKQTGLAIKTASSRSCFEHELAVSLLTGECSLRAQASLGIGGIICLMAFSLPSKQMVFPAYDADLNAYGYRLSRSGPPSVLVTESIERAFIGLGRALVYLNTSCGLTHLDVKGGNIFVNHSHFVISDCVIGDLSLMTLNTNSMAMRAEFEIDTGEEEIKTLRLPRSASQMTFSFVIGHGLNQPISVIADFINNSGLAKSTGPIKHDVGLTIDLYALGQALLELLLVGCISPCLSVPILRTATYYYYSNKLSVDYALDLLAYRCSLYPALFPTTPLTTIYGIPWDQVEGVFESIAGAHHREAFRAHLERYRLTHRRLFASIRIPSAFTGVLELVSLLCHANEKARLSIPLLWTPRP
What is the function of this protein?
Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression.  Regulates the nuclear localization of viral envelopment factors UL34 and UL31 homologs, by phosphorylating the US3 kinase homolog, indicating a role in nuclear egress.  Disrupts host nuclear lamins, including LMNA and LMNB1.  Phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI).  Phosphorylation of glycoprotein E (gE) by UL13 homolog alters its subcellular localization, from the host early endosome to the plasma membrane.  Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator ICP22 homolog (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase UL13 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Virion tegument. Host nucleus.
Protein: LIPB_ECOK1
Sequence: MYQDKILVRQLGLQPYEPISQAMHEFTDTRDDSTLDEIWLVEHYPVFTQGQAGKAEHILMPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVNTLAELGIEAHPRADAPGVYVGEKKICSLGLRIRRGCSFHGLALNVNMDLSPFLRINPCGYAGMEMAKISQWKPEATTNNIAPRLLENILALLNNPDFEYITA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.