PharMolix/UniProtQA huggingface dataset:
Protein: RPOC_THENN
Sequence: MPMSSFKRKIKAIQIKIASPDVIRSWSGGEVKKPETINYRTFKPERDGLFCERIFGPVKDYECACGKYKGKKYEGTVCERCGVRVESREARRKRMGHIELAAPAVHIWYLESIPSVLGTLLNMNVSDLENIIYYGSRRVIERAFIVTDPKDTPFAQGDIIYETEYRIYRKKWDFEVEQAFIVKNPRSPVLSDIDGEVILRTEKTVTGREITWIIVRNVNRAEHTVLPGMIITVKDGQEVEKGQDLTREMNVDPLYAPFDGHVEIDEISNTITVKPLTTSKDQPVVFTVPYGARVLVSNGQKVKKGDQLTTSTTLPAVKASISGRVKFGSNLNVRALEDGNFEVLSSGNVYIEQVIEERKYPVFEGALVYVNNGDQVKKGDHLADRFLFEEEYLSSTEYKIFESHYPTMFDVEERTENDRPIVVITDIDPEVSKETGLKMGDIITENEYEAYLQIYPEKIVADAGAQAIKKLLQNLDLEELRAELEAELKKLPASSSKAMKLRRRLKMVKDFIKSGNKPEWMVLEVVPVIPPDLRPMIQIEGGRFATTDLNELYRRLINRNNRLRKLLELGAPEIILRNEKRMLQEAVDALIHNGSDSEGKRSRRAVLKDRNGRPLKSLTDLLKGKKGRFRRNLLGKRVDYSGRAVIVVGPHLKIHQCGIPKKMAMELFKPFVLAKLLGEGSTSKTMRKVKKAIIEKEMPEAWEVLEEVIKGSVVLLNRAPTLHRMSIQAFEPKLVEGNAIQLHPVVCPPFNADFDGDQMAVHVPLSAAAQAEARFLMLSRYNIISPAHGKPISLPTQDIIIGSYYLTTVGKDFDSLKEEDIRWRFSSPEEAMLAYHLGYIKLHTPILIKVSIKGEEKRIKTTLGRVIFNSILPEDLRDYNRIFDKKQINALVYETFKRYGIDRAADLLDDVKDLGFHYATVSGLTLSLKDLKIPPERDEILKRTWEKVRIIEENYERGFLTEEQRKSEIIRLWMNVTEEITELTSKTLAEDPFNPIYMMVNSGARGNIDQVKQLAGIRGLMIKAYDPRSREIKSKIFKGQAIHEALTFDYPVDKNLREGVDILQFFISTYGARKGQVDTAMNTSFAGYLTRRLVDVAQSVTVTEPDCGTHEGIRAMDLIKDGTVVEKMNEFLFGRVLASDVLDPETKEVLKNPETGKEYTRNTMLTDDDANFLASYKKMVDVVKYDEIDITELSLPNMYAEIAEPVGEYKEGTELTWDVVKAARNEGKYRIKVKMYPVVGTVYANEQPLYDKKGERELLVYQEVINEVVAKLLEENGVEKVLVRPDIIVRSPLTCESEYGVCAACYGMDLSNHKIVNVGEAVGIVAAQSIGEPGTQLTMRTFHVGGVMGASDIVSGLTTVEKTFEPYAFLREEKSGGKKEIRKYYGSEAVLCEVDGFVKDIATDETGRTVIYIEDYAGGIHAYRIPKRAKVKVKKGQKVLRGDTLTTGAIVWWKLLELESEKGVLTAMNLLKIIKNAYVQQGVSIHDKHFEIIFRQMLSMALVIDPGDSDYLPDQLVPLVDIKRTNREILEGNARVEENRKWVIGKMLAKRVITETDDGELVELAQKGEEVTEELLKKFIEAGIKEIDVVEKDRVVTYQILPKEPIKYKRRLLSLKKAALNYPGWLSAAAFEETAWVLTAAAIEGKVDPLIGLKENVIVGQLIPAGTGLDVFAGIQVEETPRAAAEEKLA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: SYK_CLOK5
Sequence: MAKEEKNLHVLEENFNQLIRERIQKFKNLQEQNKDPFEVYKVERTHTSKEIKDNYETLDGTDVTVAGRLMSKRVHGKAGFSDLYDRYGKIQLYIKINDVGEEKLKEYKSYDIGDILSVSGKVFKTRTGEVSIHITDFQLAAKSLKPLPEKWHGLKDPDLRYRQRYVDLIINQDVRDTFLKRTAVIRAIREFLDGRDYIEVETPILSSIAGGAAAKPFITHHNALDIDMYLRIATELYLKRLIVGGFEKVYEIGKNFRNEGIDVRHNPEFTAMELYEAFSDYNDMMELTENMLAYVCEKVLGTTKVIYQDTEIDFKPPWNRITMVDAVKQFTKVDFNEVESDDEARKIAVEKNIELKKELKDCTKGDILVGMFEEFCEHKFIQPTFVMDYPVEISPLTKKKRGNDKYTERFEGFIFGREVCNAYSELNDPIVQRERFMQQIRERELGDDEAYMMDEDFINALEIGMPPTGGLGIGLDRIIMFLTNSYSIRDVILFPTMKPSQQ
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXH_ZYMMO
Sequence: MTQDPHKMFDEWMDEAKKAETDDPTAMALATASKQAFPCVRMMLLKGHTKDGFVFFTNLGSRKGHELLENPVATLLFHWKKLRRQVRIEGAATLISDEEADAYFATRARKSQLGAWASEQSRPLPARDVFEKRIADIEARYEGKDVPRPPYWTGFRVSPIRMEFWNDREFRLHERELFTLNDGRWQSEFLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: ATPD_STRGG
Sequence: MNSASREALAAARERLDALTDNTSVDAAKLAEELASVTALLDREVSLRRVLTDPAQSGESKAELAARLLGGQVGGETLDLVSGLVRSRWSQSRDLVDSVEELANTADLTAAQRGGNLDDVEDELFRFGRIVGSDKELRSALTSRTATASAKGELLRSLLGGKAQPVTERIIVRLVTQPRGRSLEAGLDSLSKLAAERRDRMVAVVTSAVPLSDRQKQRLGAALAKLYGRQMHLNLDVDPAVLGGISVRVGDEIINGTVAERLEEATRRMAG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: REC16_HUMAN
Sequence: MNPSEMQRKAPPRRRRHRNRAPSSHKMNKMMMSEEQMKLPSTNKAEPLTWAQLNKLTQLATKCLENTKMTQTPESMLLAALMIVSTVSAGVPNSSEETVTIENGP
What is the function of this protein?
Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript.  Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery.  This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).
What are the official names of this protein?
Endogenous retrovirus group K member 16 Rec protein, HERV-K_10p14 provirus Rec protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity).
Protein: RL2_PSET1
Sequence: MALQKCKPTSAGRRHLVKVVNSDLHKGKPYAPLLEKNSKSGGRNNNGRITVRHIGGGHKQHYRLIDFKRTKDGIPATVERLEYDPNRSANIALVLYADGERRYIIAPKGLKAGDAIQSGVDAPIKPGNALPMRNMPVGSTVHNVELKPGKGAQIARSAGAYVQILARDGQYVTLRLRSGEVRKVEADCRATLGEVGNAEHMLRSLGKAGANRWRGIRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGKPTKGAKTRKNKRTDKFIVRRRTK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: MIAB_LEPBP
Sequence: MNPTLTESQTLTPTIQLGKVYVETYGCQMNEYDSGIVKELFRKEHYETTNVVEESDIIFLNTCAVRENAHAKIYGRLQSLGYLKKKNPNLVIGVLGCMAQNLGEDLFHQELPLDLIVGPDNYRTLPELIQNIRNGEKDVQLTRLSRSETYDELEPKVVNGIQAFVTIMRGCNNFCTFCVVPYTRGRERSREPKSIIHEIKQLQEMGVKQVTLLGQNVNSYSYESYDFCALVESILKETTIERVRFTSPHPKDFPDHLISLMAKEDRFSSQIHMPLQAGSSKVLRDMKRSYTKEEYLDLVKKIQSVIPDIGITSDIIVGFPGETEEEFLETLEVVKKVKFDMSYMFKYSEREGTIAKRKFIDDVPEEVKSRRLIELVELQTKISLEKNTSKIGKIFSILIENTSKKSKQELCGRSHCGRMVVFPIPEGMSQDLSDWIGKTVNVLIEQATSATLKGKLIV
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DERI_AGRRK
Sequence: MKLAIAGDSAGEGLAKVLADHLKDRYDVSEVSRTDAGPDAFYANLADRVASGVIDGTYDKAILVCGTGIGVSISANKVPGIRAALTHDTYSAERAALSNNAQIITMGARVIGTELAKAIADAFLARTFDTNGRSAGNVQAIDEVDAKYNAR
What is the function of this protein?
Involved in catabolism of D-apiose.  Catalyzes the isomerization of D-erythrulose 4-phosphate to D-erythrose 4-phosphate.
What are the official names of this protein?
D-erythrulose-4-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: POLS_EEEV3
Sequence: MFPYPTLNYPPMAPINPMAYRDPNPPRQVAPFRPPLAAQIEDLRRSIANLTLKQRAPNPPAGPPAKRKKPAPKPKPAQAKKKRPPPPAKKQKRKPKPGKRQRMCMKLESDKTFPIMLNGQVNGYACVVGGRVFKPLHVEGRIDNEQLAAIKLKKASIYDLEYGDVPQCMKSDTLQYTSDKPPGFYNWHHGAVQYENNRFTVPRGVGGKGDSGRPILDNKGRVVAIVLGGVNEGSRTALSVVTWNQKGVTVKDTPEGSEPWSLATVMCVLANITFPCDQPPCMPCCYEKNPHETLTMLEQNYDSRAYDQLLDAAVKCNARRTRRDLDTHFTQYKLARPYIADCPNCGHSRCDSPIAIEEVRGDAHAGVIRIQTSAMFGLKTDGVDLAYMSFMNGKTQKSIKIDNLHVRTSAPCSLVSHHGYYILAQCPPGDTVTVGFHDGPNRHTCTVAHKVEFRPVGREKYRHPPEHGVELPCNRYTHKRADQGHYVEMHQPGLVADHSLLSIHSAKVKITVPSGAQVKYYCKCPDVREGITSSDHTTTCTDVKQCRAYLIGNKKWVYNSGRLPRGEGDTFKGKLHVPFVPVKAKCIATLAPEPLVEHKHRTLILHLHPDHPTLLTTRSLGSDANPTRQWIERPTTVNFTVTGEGLEYTWGNHPPKRVWAQESGEGNPHGWPHEVVVYYYNRYPLTTIIGLCTCVAIIMVSCVHPCGSFAGLRNLCITPYKLAPNAQVPILLALLCCIKPTRADDTLQVLNYLWNNNQNFFWMQTLIPLAALIVCMRIVRCLFCCGPAFLLVCGAWAAAYEHTAVMPNKVGIPYKALVERPGYAPVHLQIQLVNTSIIPSTNLEYITCKYKTKVPSPVVKCCGATQCTSKPHPDYQCQVFTGVYPFMWGGAYCFCDTENTQMSEAYVERSEECSIDHAKAYKVHTGTVQAMVNITYGSVSWRSADVYVNGETPAKIGDAKLIIGPLSSAWSPFDNKVVVYGHEVYNYDFPEYGTGKAGSFGDLQSRTSTSNDLYANTNLKLQRPQAGIVHTPFTQAPSGFERWKRDKGAPLNDVAPFGCSIALEPLRAENCAVGSIPISIDIPDAAFTRISETPTVSDLECKITECTYASDFGGIATLPTNPVKQETVQFILHQVLQLLKRMTSPLLRAGSFTFHFSTANIHPAFKLQVCTSGVTCKGDCKPPKDHIVDYPAQHTESFTSAISATAWSWLKVLVGGTSAFIVLGLIATAVVALVLFFHRH
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to target cell and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits.  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group.
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. Host nucleus. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: FUCI_ECO24
Sequence: MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALLTEKLRHACGAAVECVISDTCIAGMAEAAACEEKFSSQNVGLTITVTPCWCYGSETIDMDPTRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTSIPADVEEKLLRFARAGLAVASMKGKSYLSLGGVSMGIAGSIVDHNFFESWLGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDENNKQYQRNAEQSRAVLRESLLMAMCIRDMMQGNSKLADIGRVEESLGYNAIAAGFQGQRHWTDQYPNGDTAEAILNSSFDWNGVREPFVVATENDSLNGVAMLMGHQLTGTAQVFADVRTYWSPEAIERVTGHKLDGLAEHGIIHLINSGSAALDGSCKQRDSEGNPTMKPHWEISQKEADACLAATEWCPAIHEYFRGGGYSSRFLTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKDVHDILNKRTNSTWPTTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLASMLRIPVCMHNVEETKVYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
What is the function of this protein?
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
What are the official names of this protein?
L-fucose isomerase, 6-deoxy-L-galactose isomerase, FucIase.
What is the protein family that this protein belongs to?
Belongs to the L-fucose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECG_METTH
Sequence: MAKKDKKTLPPSGAGLVRYFEEETKGPKLTPEQVVVMSIILAVFCLVLRFSG
What is the function of this protein?
Involved in protein export.  The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).
What are the official names of this protein?
Preprotein translocase subunit SecG, Protein transport protein Sec61 subunit beta homolog.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MSH3_CRYNJ
Sequence: MPSEGSQQPSLDSFFKRKNPRVEPYSRTGNNAIIDLTDSPPNKKIKLDDEGSQKNRSMTQTSSSYFKGHPTARPLSVDKRLPRKPSAAIQAYKLQDVIPPQPSHSGLAFETCSLVPQASFVPDSQPEPSASPAPQRTTEQLKRHEEWKTRILAMSGSFRRKRSLALDEAVAAEAREAAGLEDEGTPFDGSDGDDYKSESEKNAEEVGKQLKKYVAKELAGKGKSKGKKKEEIGPSGLAYTPLEKQFMEIKEQNRDVLLLMEVGYKYKFHGEDAKTASRELGIVAFPNRNFFTASIPTHRLHIHVKKLLSLGYKVGVITQTETAALKKIGDNRNAPFARKLTHLFTAATYVEDPSLSSSSSSSSSVRFDDPVVPGTAPPPTNALVAIVEQPVDRASDDRVKVGLVCVVPGTGDITWDEFDDSQIRTELETRLAHLSPAELLLPKQRLSKATEKVLTYFAGEPKHRGRNAVRIERIDNIPEYDAAFDFLTNFYHCKEHKATVSKGDVNDERHLMTEGNKQWSLQPKLSQDGADISLDEEIYLASGVSSSKAILTLVDFPKQVVISMAVAIRYMKRFGLENAFKHTSSFVRFANRSHMLLSSNTLANLEIYQNQTDGGLYGSLIWLLDHCKTRMGKRLLREWVGRPLLDVAALKARADAIEEIMENNSYHMEKLRSLLINMPDLVRGLTRVQYGKATPNELATLLITLVRLASEFKPNMGNVFRSCLLNNIPNTLPTILDTSQRFLNALNLKQARENDVANLWADPDRFPDIQDVKDCISVCEMELNEHLMELRKILKKPTLRYITVSGIEYLVEVPIRDTKIVPAQWMKISATRTVNRYHTPKILAITKERTQHLEKLSIVAREAFIAFQSEVAEYHELVVVSKQIAVIDCLMSLAQTAAASGYCKPKFVAEPELKILAGRHPMVEMLREESYVPFDIHFSKEEGTTKIITGPNMAGKSSTVRAMALIVCMAQIGSFVPAASVTLSVHDSVQTRMGASDEIGRGKSTFMVELSETSDILQTITPRSLVVLDELGRGTSTYDGIAIAYATLSHIAEIGCNTLFVTHYPTVAQDLAREKPDKISNWHMSFDEIQMPDGGAEITFLYQLTRGLQEASFGVWCARLAGLPKPILDTAQMRSSSLKAETQERLRGIVARRVGWMLHNLFDNKTSSSQVLRNVEMLHNSLSSSSISFSQ
What is the function of this protein?
Component of the post-replicative DNA mismatch repair system (MMR).  Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair.  MSH3 provides substrate-binding and substrate specificity to the complex.  When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs.  Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication.  After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MSH3, MutS protein homolog 3.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SSRP_CUTAK
Sequence: MPREQGVRVVARNRRATHDYTIGDTWEAGLVLQGTEVKSLRAGKATLTDAFAQVDERGEVWMYNLHIPEYAFGTWRNHDVMRKRKLLLNKREIAKLSREADGPGKTIVPLQLYFKDGYAKVEIAVGTGKRDWDKRQAIRERDAKREAQRALANRVRNRKR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: W_NIPAV
Sequence: MDKLELVNDGLNIIDFIQKNQKEIQKTYGRSSIQQPSIKDQTKAWEDFLQCTSGESEQVEGGMSKDDGDVERRNLEDLSSTSPTDGTIGKRVSNTRDWAEGSDDIQLDPVVTDVVYHDHGGECTGYGFTSSPERGWSDYTSGANNGNVCLVSDAKMLSYAPEIAVSKEDRETDLVHLENKLSTTGLNPTAVPFTLRNLSDPAKDSPVIAEHYYGLGVKEQNVGPQTSRNVNLDSIKLYTSDDEEADQLEFEDEFAGSSSEVIVGISPEDEEPSSVGGKPNESIGRTIEGQSIRDNLQAKDNKSTDVPGAGPKDSAVKEEPPQKRLPMLAEEFECSGSEDPIIRELLKENSLINCQQGKDAQPPYHWSIERSISPDKTEIVNGAVQTADRQRPGTPMPKSRGIPIKKGAQTRNIHLLGRKTCLGRRVVQPGMFEDHPPTKKARVSMRRMSN
What is the function of this protein?
Prevent the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta).  Interacts with host STAT1 protein in the nucleus, blocking it's phosphorylation by IFN-alpha/beta.  Also blocks antiviral state induced by Toll-like receptor 3/TLR3 binding to dsRNA.
What are the official names of this protein?
Protein W.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RS12_BURL3
Sequence: MPTINQLVRKGRQSETTKSKSPALQDCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVISYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHMVRGSLDTQGVKDRKQARSKYGAKRAKAAK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ATI_CAMPS
Sequence: MELTNLIEKCTKHSKDFATEVEKLWNDELSSESGLSRKTRNVIRNILRDITKSLTTDKKSKCFCILERSTINGEQIKDVYKTIFNNGVDVESRINTTGKYVLFTVMTYAAAELRLIKSDEIFALLSRFFNMICDIHRKYGCGNMFVGIPAALIVLLEIDHINKLFSVFSTRYDAKAYLYTEYFLFLNINHYLLSGSDLFINVAYGAVSFSSPISVPDYIMEALTFKACDHIMKSGDLIYIYAFTKKVKDLFNTKSDSIYQYVRLHEMSYDGVSEDTDDDDEVFAILNLSIDSSVDRYRNRVLLLTPEVASLRKEYSEAEPDYKYLMDEEVSAYDKHLPKPITNTGIEEPHATGGDKEDQPIKVVYPPNNDKDDAIKPHNPLEDPNYVPTITRTDIGIADYQLVINKLIEWLDKCEEECGNGGEFKTELEEAKRKLTELNAELSDKLSKIMSLERDSVNKTERIDRLTKEIKELRDIQNGTDDGSDSSEIDKKIIRELRESLDREREMRSKLEKELDTIRDGKVDGSCQRELELRRMWLKQRDDDLRAEIDKRRNVEWELSRLRRDIKECDKYKEDLDKAKATISNYVSRISTLESEIAKYQQDRDTLSVVRRELEEERRRVKDLESRLDECTRNQEDTQEVDALRSRIRELENKLTDCIESGGGNLTEISRLQSRISDLERQLNECRGNVTEISRLESRISDLERQLNDCRRNNETNAETERDATS
What is the function of this protein?
Structural protein that forms a matrix surrounding the mature virion (MV) through interaction with protein A26.  Presence of protein A25 in the virion structurally prevents direct virus-cell fusion mechanism (By similarity).
What are the official names of this protein?
A-type inclusion protein A25 homolog, ATI.
What is the protein family that this protein belongs to?
Belongs to the poxviridae A25 protein family.
What are the subcellular locations of this protein?
Virion. Note=Present above the membrane of mature virions (MV).
Protein: DNAL1_HUMAN
Sequence: MAKATTIKEALARWEEKTGQRPSEAKEIKLYAQIPPIEKMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLEEKHSAENNWIEEATKRVPKLKKLDGTPVIKGDEEEDN
What is the function of this protein?
Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity).  Component of the outer arm dynein (ODA).  May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity).  Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (PubMed:21496787).
What are the official names of this protein?
Dynein axonemal light chain 1, LC1.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain LC1-type family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: CYB_SCAEL
Sequence: MTNMRKTHPLMKIINESFIDLPTPSNISAWWNFGSLLGLCLVIQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTFIETWNIGVLLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWTWGGFSVDKATLTRFFAFHFILPFIVAALAVVHLLFLHETGSNNPIGLNSDVDKIPFHPYYTIKDALGFLLLILVLLMLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVIALVLSILILALVPFLHNSKQRSMIFRPISQCLYWLLVADLLTLTWIGGQPVEHPFIIIGQIASILYFSIILILMPLASMLENKMLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
Protein: TLK1_MOUSE
Sequence: MSVQSSSGSLEGPPSWSRLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVATGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAESQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPVVQPKQLSFKITQTDLTMLKLAALESTKNQDLEKKEGRIDDLLRANCDLRRQIDDQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLGKRKPPTANNSQAPATNSEAKQRKTKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMSGLTATPTPPSSSIITY
What is the function of this protein?
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase.  This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity).  Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs.  In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase tousled-like 1, Tousled-like kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATC_STAA9
Sequence: MTKVTREEVEHIANLARLQISPEETEEMANTLESILDFAKQNDSADTEGVEPTYHVLDLQNVLREDKAIKGIPQELALKNAKETEDGQFKVPTIMNEEDA
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.