PharMolix/UniProtQA huggingface dataset:
Protein: CH60_AYWBP
Sequence: MSKKILYGKEARKALLQGVDAIANTVKVTLGPKGRNVILEKAYESPAIVNDGVSIAKEIELKNPYQNMGAKLVYEVASKTNDKAGDGTTTATVLAQSMIHRGFDAIDAGANPVLVKEGIELASLTVAKKLLAKSKKVDDQEDIQNVASVSSGSQEIGKIIAQAMQKVGKDGVINVDESKGFETELEVVEGLQYDKGYASPYFVSDRESMTVHLENALVLVTDHKISTVQEIVPILEEVVKASRPLLIVAEAVENEVLGVLVANKLRGTFNVVVTNAPGFGDNQKEMLKDIAVLTKANFVFKDLNMKLADLKMDDLGNINKVIIKKDNTTLISNSKSPELEKRIQLLKTQIKNSTSDYETKNLQERLAKLSGGVALIKVGAATDTELKDKKLRIEDALNATKAAITEGIVVGGGKALVEVYQELKDTLVSDNKEVQQGIDLVVQSLLVPTYQIAYNAGFSGKDVVKQQLLQPSNFGFNAKEGKYVCLLKEGIIDPTKVTRQAVINAASISALMITTEAAVVSFKENKDNNFDLGTQE
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP166_BPPZA
Sequence: MKMLTHTCFYCSFSFFTRKFDVFGAITKKDTPVVFCPACGNQSLTVSHIEEEIG
What are the official names of this protein?
Gene product 16.6, gp16.6, Protein p16.6.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus gp16.6 family.
Protein: RR4_BUXMI
Sequence: MSRYRGPRFKKIRRLGALPGLTSKRPRAGSDLRNQSRSGKRSQYRIRLEEKQKLRFHYGLTERQLLKYVRIAGKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSYRCKPRDIITAKDEQKSRALIQNYLDSSPHEELPKHLTLHSFQYKGLVNQIIDSKWVGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RF1_RIPO1
Sequence: MAESYLLEKLQSVDQTYQELTHRLADPDIATNPDELQRVARLRSSLEETVLTYDSWKQTQEELIGAKQILKDAGGDPEMREMAALEVEELAEKLEELEKKLKILLLPRDPNDDKNIMLEIRAGTGGDEASIWAGDLVRMYSRYAESQKWTVKLVSESLADMGGFKEAILEIQGDRVYSKLKFEAGVHRVQRVPVTEAGGRVHTSTATVAIMPEVDDVEVQIDAKDIEITTARSGGAGGQNVNKVETAVDLFYKPLGIRIFCTEERSQLQNRERAMQILRAKLYDLKLREQQDAVSSMRKSQVGTGARSEKIRTYNYKDNRVTDHRLGQNFSLAGTLEGDIEEIIQSCISQDQQERLEELAASPETASAIN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_BACFR
Sequence: MARYTGPKSRIARKFGEGIFGADKVLSKKNYPPGQHGNSRKRKTSEYGIQLREKQKAKYTYGVLEKQFRNLFEKAATAKGITGEVLLQMLEGRLDNIVFRLGIAPTRAAARQLVGHKHITVDGQVVNIPSYAVKPGQLIGVRERSKSLEVIANSLAGFNHSKYAWLEWDEASKVGKLLHIPERADIPENIKEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: FABH_RALPJ
Sequence: MTRFARIIGTGSYLPPKRVTNDELAAQLAEKGIETSDEWIVSRSGIRARHFAEPDVTCSDLAVRAAERAIEAAGIDRSELDLILVATSTPDFVFPSTACLVQQKLGITNGCAAFDVQAVCSGFVYALATADKFIRSGAYRNVLVIGSEVFSRIIDFSDRTTCVLFGDGAGAVVLQASDEPGILSTALHADGSHANILCVPGNVAAGAIQGSAFLYMDGQAVFKLAVTVLDKVAREALAAAELDASQVDWLIPHQANIRIMQGTTKKLGLSNERLIVTVDEHGNTSAASIPLALDVAVRDGRIQRGQHVMLEGVGGGFTWGAALLRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICDHC_ARATH
Sequence: MAFEKIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAEATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVPGWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKTETEVFTFTGEGGVAMAMYNTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFTEKLEAACVGTVESGKMTKDLALIIHGSKLSRDTYLNTEEFIDAVAAELKERLNA
What is the function of this protein?
May supply 2-oxoglutarate for amino acid biosynthesis and ammonia assimilation via the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway.  May be involved in the production of NADPH to promote redox signaling or homeostasis in response to oxidative stress, or redox signaling linked to defense responses.
What are the official names of this protein?
Cytosolic isocitrate dehydrogenase [NADP].
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: Y3545_SINMW
Sequence: MKAERSDDLKLKALKRGHLAEYRAALCLILKGYRIVAMRYRTRLGEIDIIARRGDLIACVEVKARRSFDDAIFAVSSTAQRRIRAASEVWLSRQGDFHRLSLRYDIVAVMPWRWPRHLTDAF
What are the official names of this protein?
UPF0102 protein Smed_3545.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: IL12A_MOUSE
Sequence: MCQSRYLLFLATLALLNHLSLARVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA
What is the function of this protein?
Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine.  IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity (PubMed:8766560).  Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits.  Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2.  In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity).  As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (PubMed:18033300, PubMed:30197594).  Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers.  Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
What are the official names of this protein?
Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HBBA_CATCL
Sequence: VEWTDAERSAILSLWGKIDTDELGPALLARLXLVXXXTQRYF
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-A, Beta-A-globin, Hemoglobin beta-A chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: DPN_DROME
Sequence: MDYKNDINSDDDFDCSNGYSDSYGSNGRMSNPNGLSKAELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGLFPATAVTAAPTPLFPSLPQDLNNNSRTESSAPAIQMGGLQLIPSRLPSGEFALIMPNTGSAAPPPGPFAWPGSAAGVAAGTASAALASIANPTHLNDYTQSFRMSAFSKPVNTSVPANLPENLIHTLPGQTQLPVKNSTSPPLSPISSISSHCEESRAASPTVDVMSKHSFAGVFSTPPPTSAETSFNTSGSLNLSAGSHDSSGCSRPLAHLQQQQVSSTSGIAKRDREAEAESSDCSLDEPSSKKFLAGAIEKSSSAWRPW
What is the function of this protein?
Transcriptional repressor of genes that require a bHLH protein for their transcription (PubMed:1427077, PubMed:28899667, PubMed:24618901).  In the larval brain, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma-HLH (PubMed:28899667, PubMed:23056424, PubMed:21262215, PubMed:24618901, PubMed:22357926).  As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch (PubMed:21262215, PubMed:22357926, PubMed:23056424).  In the developing larval and pupal brain, required for mushroom body differentiation (PubMed:22357926).  Involved in sex determination and SXL transcription repression when in complex with the corepressor protein Groucho (PubMed:8001118, PubMed:7651341).
What are the official names of this protein?
Protein deadpan.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAC_STRS7
Sequence: MFNDMPVFDYEDIQLIPNKCIINSRSEADTSVRLGNYTFKLPVIPANMQTIIDETIAEQLARDGYFYIMHRFDEQGRKPFIQRMHEQQLIASISVGVKDYEYDFVSSLKEDAPEFITIDIAHGHADSVIKMIKHIKAELPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAAVRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHIESPGKMVEIDGQSFKEYYGSASEYQKGEHKNVEGKKILLPTKGHLADTLTEMKQDLQSSISYAGGRELESLRRVNYVIVKNSIWNGDSI
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: PTH_LACPL
Sequence: MKMIVGLGNIGRQYAQTRHNVGFMIVDELASKLNVTFQTSKFEAQVATAFQDGEKILLVKPATYMNDSGRAVGPLMSYYNVDPADLLVIHDDLDLPLGKVRLKQKGSAGGHNGIKSIISHVGDQHFKRVKVGIDHPQKMSVVDYVLGKFTPAEVAKFDDAKITALAAVEAWLANDDFTAVMNQYN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_BIFA0
Sequence: MAELTIDPATIRKALDDFVEAYTPSETPTQEVGHVATAGDGIAHVTGLPGCMANELLTFEDGTLGLAFNLDAREIGVVILGDFVGIEEGQEVRRTGEVLSVPVGDGFLGRVVDPLGRPIDGMGEIKSEGRRILEAQAPDVMHRHPVDQPMSTGLKAIDAMTPIGRGQRQLIIGDRQTGKTAIAIDTIINQKKNWESGDPKKQVRCIYVAIGQKGSTIASVKQSLEEAGAMEYTTIVASPASDSAGFKYIAPYTGSAIGQHWMYNGKDVLIVFDDLSKQAEAYRSISLLLRRPPGREAYPGDVFYLHSRLLERCARVSDDLGGGSMTGLPIVETKANDVSAYIPTNVISITDGQIFLQSDLFNAGQRPAVDVGISVSRVGGAAQTKALKKVSGTLKISLARYRSLESFAMFASDLDAASKAQLNRGARLTELLKQPQFSPYSMEQEVVSVWAGTHGKFDDLAIADVLPFEHGLLEYVDRNTDILTTIRDTGDFTKETEEALDKAVDAFRETYVTKAGKPLVDKKTAPKSVTPVDQEQIKAGKAQEKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RT109_ASPFL
Sequence: MSKVDVDLGDLLAKVLPTGVKVTIRHISSAPTPCTALFTPPPGEESESTFCENHFLTVSVNADEHDGPEIIVFGIEVLVYSTAHLTTVFVSKADSTGFLHLLKNAPKVSLIRRISNGFLSFLVQTHQRPGVRLVVSLFARAQNQYLFPGSIENSGKHVLDDRGLIKWWCRVVDPILREYEPESGSHEKGLLDRAMESAKSSATAFLIVPGCDKFETRGFFPGTAKSDDKERPRWLNSYPLHQLCDNTDAPPRCLVPRFPDDPKTRFLLDLDDELPQKLEAAGSKEGAGQWRSVKSLDQFWEMMSFRQECSAGRLVGFLWLVINPPGLVNSVQMTSSRPVFKEKAEGSLTTTVPVYDKVDSKPTGTAVSVSTDSQSSDTAKDSTAEATSGGPVQDPSTQTGSLSSETHPKVQPNTDQNAFYWPEAGRGHAVMSEEDYKTAINFLLEQDFYNEKVSIASTKAWSEKVASIVDQLWVGQQVTGRNTSGESADKHAPTTNIINTGLVRKRKKDEPSQATTATSAQKEGCEGNGTVSTAVTAEASTTGTNESPGVNVLQANLIRKKKKA
What is the function of this protein?
Histone chaperone-dependent acetylase that modifies 'Lys-56' of histone H3 (H3K56ac) (PubMed:33823938).  Histone H3 'Lys-56' acetylation may be required for S-phase-linked DNA damage tolerance (By similarity).  Also acetylates 'Lys-9' of histone H3 (H3K9ac) (PubMed:33823938).  Autoacetylates (By similarity).
What are the official names of this protein?
Histone acetyltransferase rtt109.
What is the protein family that this protein belongs to?
Belongs to the RTT109 family.
What are the subcellular locations of this protein?
Nucleus. Vacuole.
Protein: FPG_NITWN
Sequence: MPELPEVETVRRGLQPAMEGATIVRAETRRKDLRFPFQTDFVARLEGQAVTGLGRRAKYLLADLASGDVLLMHLGMSGSFRVIDAAGVTVPGDFHRPRGEDRVHDHVRFTMSSRAEIVFNDPRRFGYMKIVARSALGDEPLLKGLGPEPLGNEFDAAVLAHGCRNRKTSLKAALLDQRVVAGLGNIYVCEALFRARLSPRRLAATLAMKTGAPSERAERLVGAIRDVLNQAIEAGGSSLRDHRQTTGELGYFQHSFQVYDREGDKCRTPACKGAVKRFTQNGRSTFWCPVCQT
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: PALAD_THUAT
Sequence: MALVFKSIGAHKTPPCTLNLASPALYHTRVTMASTITHPPPLKDRKISSTRRVRTYPLAPEKAEIFNSMHGWVEDTILPFLKPVEESWQPTDFLPDSTSDGFHEQVEELRKRTADLPDDYLVALVGAMVTEEALPTYQTMLNTTDVIYDESGASPVPWAVWTRAWTAEENRHGDIVNKYLYLSGRVDMKQIEKTIQYLIGSGMDPGADNNPYLAYIYTSYQERATAISHGSLGRLARQKGEMKLAQICGTISADEKRHEAAYSKIVEKLFELDPEGTMLALAYMMKMKIVMPARLMHDGKDPDMFQHFSAVSQRLGIYTAKEYTDILEHMIARWGVDKLTGLSGEGRRAQDYVCGLPMRFRKVEERAQAWAENISHVPFSWIFGRRV
What is the function of this protein?
Delta(6) fatty acid desaturase introducing a cis double bond at carbon 6 of palmitoyl-[acyl-carrier protein](16:0-ACP), producing 16:1(6Z)-ACP (PubMed:7961667, PubMed:9144157).  No activity with the coenzyme A ester of the fatty acid (PubMed:7961667).  The position of the double bond is determined by its distance from the carboxyl end of the fatty acid (PubMed:7961667).  Low activity with several saturated acyl-[acyl-carrier protein]s, including 14:0-ACP and 18:0-ACP (PubMed:7961667, PubMed:9144157).  Requires reduced ferredoxin for detectable in vitro activity (PubMed:7961667).
What are the official names of this protein?
Acyl-[acyl-carrier-protein] 6-desaturase, Palmitoyl-acyl carrier protein desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SI12A_XENLA
Sequence: MWPVLWAAARTYAPYITFPVAFVVGAVGYQLEWFIRGTPEHPVEEQSIQEKREERTLQETMGKDVTQVISLKEKLEFTPKAVLNRNRQEKS
What are the official names of this protein?
Small integral membrane protein 12-A.
What is the protein family that this protein belongs to?
Belongs to the SMIM12 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL5_PARMW
Sequence: MSLKKRYRETIQPKLQKDLSLTNIHEVPKVVKVTVNRGLGEAAANAKSLEASVNELAQITGQKVVVTRAKKAIAAFKIRQGMPIGCAVTLRGDRMYAFLERLINLALPRIRDFRGVSPKSFDGRGNYTLGVREQIIFPEISFDKIDAIRGMDITIVTTARSDEEGRALLREMGMPFQSN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ENPP6_PIG
Sequence: MAMKFGALLLVLVLSLAQPASGRRKLLVFLLDGFRSDYISDEALESLPGFKEIVSRGVKVDYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPATNKSFDIGVNRDSLMPLWWNGSEPLWITLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKNVPTDINFANAVSDALDFFKSGQADLAAIYHERIDVEGHHFGPSSPQRRDALKAVDTVLKYMTEWIQERELQDDLNVIIFSDHGMTDIFWMDKVIELNKYISLNDLQQVKDRGPVVSLWPAPGKHSEIYNKLRRVEHMTVYEKEAIPSRFYYKKGKFVSPLTLVADEGWFITENRELLPFWMNSTGKREGWQRGWHGYDNELRDMRGIFLAFGPDFKSNFRAAPIRSVDVYNVMCSVAGITPLPNNGSWSRVVCMLKDPVSSAPAALPSACVLALILLWLLA
What is the function of this protein?
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells.  Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids.  In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.
What are the official names of this protein?
Glycerophosphocholine cholinephosphodiesterase ENPP6, GPC-Cpde, Choline-specific glycerophosphodiester phosphodiesterase, Ectonucleotide pyrophosphatase/phosphodiesterase family member 6, E-NPP 6, NPP-6.
What is the protein family that this protein belongs to?
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: CDH_SALPB
Sequence: MKKTGYFLLAVIVIVAATGVGYWKFSGNPDALREIVLEQCLPDQLQHQNPAPCAEVKPRAGYVVFKDRHGPLQYLLMPTYRINGTESPLLLEPATPNFFWLAWQARGYMSKKYGHDIPDSAVSLAINSRLGRSQDHLHIHISCIRPDVREQLDNDLTRISTRWLPLPGGLMGHEYLARRVTESELAQRSPFMMLAEEVPEARDHMGRYALAVVRQSDDSFVLLATERNLLTLNRASAEEIQDHSCAILSSR
What are the official names of this protein?
CDP-diacylglycerol pyrophosphatase, CDP-diacylglycerol phosphatidylhydrolase, CDP-diglyceride hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Cdh family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: FOLD_ECOL5
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDALNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: COBS_BRUO2
Sequence: MQRNGLIGDTIRSLGFLSRLPLPQGWFDNTDDSLPRNARAFPLAGGILGLLAGVALLIANAISLPPLAAALIAIGALAAMTGALHEDGLGDTADGFFGASTPDRRLDIMKDSRIGTFAALTLVIWTSVKASLLMAIIARAGAGYALLALIGTEAASRAGMLAFWHALPSARPGGLADSMGQPQWETVVCGCGLGLALLAIGFLPSGGMVALINALVLMTVVLFGFARLCMAKIGGQTGDTLGAAQQIGSLAALIGLVMAL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENV_HV1MF
Sequence: MRVKEKYQHLWRWGWKWGIMLLGILMICSATENLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVCATHACVPTDPNPQEVILVNVTENFDMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVNLKCTDLKNDTNTNSSNGRMIMEKGEIKNCSFNISTSIRNKVQKEYAFFYKLDIRPIDNTTYRLISCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNDKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEGVIRSANFTDNAKTIIVQLNTSVEINCTRPNNNTRKSIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWMSTLKQIASKLREQFGNNKTVIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQFINMWQEVGKAMYAPPISGQIRCSSNITGLLLTRDGGKNTNESEVFRPGGGDMRDNWRSELYKYKVVKIETLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLEQFWNNMTWMEWDREINNYTSLIHSLIDESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKIFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTHLPNRGGPDRPEGIEEEGGERDRDRSVRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGAYRAIRHIPRRIRQGLERIL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.