PharMolix/UniProtQA huggingface dataset:
Protein: NVD_DANRE
Sequence: MENTRASLMFKTLAVAAIGLSATFVMLVRDPSDTLFGGGYPELWRRTGLAGAPTRAAACIFAGVFLLAMGWLYRLLFAPLELLRGVDEVGYIAEDGRSRAQAANEVRRRRKTGELPPVYPNGWYRVLDSHMLERGDVKSVTVLGQQVAVFRGQDGKAYVVDAYCPHLGANLAVGGRVVGGCIECPFHGWQFRGVDGRCVKIPYADKVPEFAKVRCWPSCEINGLVLVWFHCDGLEPSWRVPEQSQITRGEWVYRGRTEHFINAHIEEIPENAADIAHLAHLHTPGIVSGVDLRYTNSKTWEFIRHDWKVEWKPEPEPNKHCSQMLVKHALTVFGRHWPLLDLDVLARQVGPGVVFLLFEHSFLGRGVIMHCVTPVEPLLQCVSHTIFYQSSIPPLVPKFILRAECIQFERDVMIWNNKTYISKPMLVKEDSAIQKHRRWFSQFYSENSPRLRYQHDTLDF
What is the function of this protein?
Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol.  This reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid.
What are the official names of this protein?
Cholesterol 7-desaturase nvd, Protein neverland, Nvd protein, nvd-Dr.
What is the protein family that this protein belongs to?
Belongs to the cholesterol 7-desaturase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YL352_MIMIV
Sequence: MNNYFDAGNFNTVFNNPNQMSVHGYDPKSGFNNHGFMNRNNLLSNNLCNNLLDEEITEYSVLIDSKDRNYQVYPDPFKYTVKFNPLRRTTEIIDGEKVVNEEPMPVINDNFKNVKYIRLESIILPFYTKIRFVDEDIDGDIVQRAKVNTSKPLTDNLYVLMRIEEFKGVNYKSSNDVLAESFAVIYFDNKISNTHYEGKCNGGIKIFPSDKLGTINSLKISFVSPYGEEINCDHLMKEIKSNMICNCDDPEGDEYTDCFKHNLFHPLNPIFQHHVHFKIGVVTPRLNKLNFN
What are the official names of this protein?
Uncharacterized protein L352.
What are the subcellular locations of this protein?
Virion.
Protein: P23A_ARATH
Sequence: MSRHPEVKWAETTEKIFLTVVLADTKDTKVNLDPEGVFDFSAKVGPENHVYELKLELADKVNVEESKINIGERSIFCIIEKAEPERWNKLLRVKKPPHYVKVDWDKWVDEDDEGSAGAADMDMAGMEGMGGMGGMGGMGGMGGMGGMGGMGGMEGMDFSKLMGGMGGMGGMGGLEGLGGMGGMGGMGGMGGMGGMEEFEDSDDEEETAKSGDKKDDAVKEEGLATEKAPAAEETTSVKEDK
What is the function of this protein?
Acts as a co-chaperone for HSP90 (PubMed:20349287).  Controls root development through the modulation of auxin distribution in the root meristem (PubMed:26163704).
What are the official names of this protein?
Co-chaperone protein p23-1, Atp23-1, p23 co-chaperone.
What is the protein family that this protein belongs to?
Belongs to the p23/wos2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS4_RUMCH
Sequence: MARYTDASCRLCRREGEKLFLKGERCYTDKCSVARRPYAPGQHGQGRKKMSEYGIQLREKAKVRRFYGVLEGQFSKYFEVASRRKGITGENLLQILETRLDNVVYRLGLGTSRPESRQLVTHGHFTVNGKRVNIPSYLIKVGDVIAVADNSKNSPKVKSIREIAGGKVIPKWLEFDEENLVGKVVALPAREDIDLPIKEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: SYM_PSYA2
Sequence: MKVREILVTSALPYANGDIHLGHLVEYIQTDIWVRSMKAQGHKVTYVCADDAHGTAIMLKAEDNGVTPEQQIANVQAAHEADFAKFLINFDNYHSTHSEENREFSELIYRRLRDTGHISTRDVEQLFDPEKQLFLADRFVKGTCPECAAPDQYGDNCEVCGTTYDATELKDPYSTLSNATPILKTSKHYFFDLPEFEQFLKDWTRSDNRLQVSVANKLQEWFDAGLTSWDISRDAPYFGFQIPDTPSDEPDKYFYVWLDAPVGYMASFKNLCDKRAGTDDALDFDHYWAQENEHKTEVYHFIGKDIVYFHALFWPAMLAGSELRTPTAVFAHGFLMVNGEKMSKSRGTFIKADTYAEHLHPEYLRYYFASKLSDKVEDINLDLEDFMQKVNSDLVGKVVNIASRSAGFLLKKYDGMLTDVCAEPSLLEDITKTGDEIAAAYENREFSRAMRLIMQCADKANEYIDEKKPWALAKVEGAEQEVQDVCSVAINIFRQLMVYLAPVLPELTANAKEFLNINDLSFASRNEWLLGHQINKFKPLMQRIDEKDVAAMVDASKASLTQVDAPTASQDDKMVAKNTAPAATPSSTEQADYIGIEDFAKVEMKVAHVIACSYVEGADKLLQFTLDVGEAQPRNVFSGIRKFYEPEQLLDKKVICVTNLAPRKMKFGISEGMILSSGDPKTQLTVVTLPDNCVIGDLLA
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_HYDS0
Sequence: MRSDIIQKGYDKAPHRSLLRACGFKDEDFGKPIIGVANSYIDIVPGHVHLREFVEPIKEEIRKAGAIPVEFNTIGVDDGIAMGHYGMHYSLPSRELIADAIETVVEAHQLDGLICIPNCDKIVPGMLMGALRVNVPTVFISGGPMAAGKIGDKKVDLISVFEGVGKLNKGEITEKDLLVIEQNACPSCGSCSGLFTANSMNCLTEVLGLGLPGNGTTLAIDPRREMLARQAARQVVELVKIDLKPRDIVTKASFDNAFRVDIAMGGSSNTVLHLLAIAREAGIEYKMEDIDKISRETPTLCKISPSSDYHMDDLDRAGGISAIMKELLRNGLFDGKQRTVTTKTIEEIVKDVEIMDENVIRRIDNAYSKDGGLAILFGNLAPKGSVVKTAGVAKEMLQFKGKAICFDSEEEAIEGIRGGKVKPGHVVVIRYEGPKGGPGMREMLSPTSTIMGMGLGSSVALITDGRFSGGTRGACIGHISPEAAAGGPIGIVQDGDEILIDIPNRKLELLISQEEFDARLKAFKPKEKLIKSSWLKRYRKFVKDASEGAILSAD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: T3HPD_BACHK
Sequence: MKVSKVYTTIDAHVAGEPLRIITGGVPEIKGDTQLERRAYCMEHLDHLREVLMYEPRGHHGMYGCIITPPASAHADFGVLFMHNEGWSTMCGHGIIAVITVGIETGMFEVTGEKQNFIIDSPAGEVIAYAKYNGSEVESVSFENVPSFVYKKDVPIIIDDYEFQVDIAFGGAFYAVVDSKEFGLKVDFKDLSAIQMWGGKIKHYIESKMEVKHPLEEGLKGIYGVIFSDEPKGEDATLRNVTIFADGQVDRSPCGTGTSARIATLFEKDALQKGEIFVHECITDGKFEGEVLSVTAVDTYEAVVPKVTGHAFITGFHQFVVDPRDDLKRGFLLG
What is the function of this protein?
Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C).  Is likely involved in a degradation pathway that converts t3LHyp to L-proline.  Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp) in vitro.  Displays no proline racemase activity.
What are the official names of this protein?
Trans-3-hydroxy-L-proline dehydratase, T3LHyp dehydratase, t3HypD, Trans-L-3-hydroxyproline dehydratase.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: ATPA_ROSS1
Sequence: MAVATTEELYQRLLRSIREGVDLQPKMVNVGTVIQVGDGVARISGLEQAMASELLEFPPKAGRSEPVYGIALNLEKDSVSAIILGDYLGIEEGDQVNSTGRVISVPVGQALIGRVVNALGQPIDGKGPIQTTTYRPIERIAPGVITRKSVDTPVQTGIIAIDSMIPIGRGQRELIIGDRQTGKTAVAIDTIINQKGQGMVCIYVAIGQKRAQVAQIINILEKYGALDYTIVVAATASESAALQYIAPYAGCAMGEEVMENGVMIDGREVRDALIVYDDLSKHATAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARLNEDYGGGSLTALPIIETQANDVSAYIPTNVISITDGQIYLETDLFNAGIRPALNVGISVSRVGGAAQTRAMRSVSDRLKIDMAQFRDLAAFAQFASDLDATTRAQIERGQRLQEVLKQPQFQPMPLEEQVVILFAGINGYLDDVPINQIGRFKAELFTYMRTAHPEVGKMIYDNRLDRKFPSPEIRSAIENMLKEFKQMSDFSAEQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CYREN_RAT
Sequence: METLKSDNKKRVLPSWMTAPGNERKVVSVKTAKRKQTAAIRVGAATRAPAKETVYCMNEAEMVDVALGILIEGRKQEKPWEQPSLVAPDKLQLSPPCSESPHTSSPGSSSEEEDSRTDSPALGLSPARGPEASNSPCSRSPEEGKEEEDELKYVREIFFS
What is the function of this protein?
Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (By similarity).  Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present.  Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination.  Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (By similarity).  In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin.  Also involved in immunoglobulin V(D)J recombination (By similarity).  May also act as an indirect regulator of proteasome (By similarity).
What are the official names of this protein?
Cell cycle regulator of non-homologous end joining, Cell cycle regulator of NHEJ, Modulator of retrovirus infection homolog.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (By similarity). Localizes to DNA damage sites (By similarity).
Protein: BTN1_GIBZE
Sequence: MSGISPSSSGLLPMPGAPSSSWSAYKARVAALLGHHDTKVVVAFWLFGLINNVLYVIILSAAQDLVGSLPKGVVLLADVVPSFLTKLIAPYFIHRIPYRTRILIFIALSAAGMLMVALTPATQSVAIKLVGVILASISAGGGELSFLGLTHFYGPMSLAGWGSGTGAAGLVGAGLYVMFTDWWGLSVRSSLLISACFPAIMFLSFFVILPLGPLREGTRKDYDAIPDLEDEDVNHMDQGTASSALLAPGPSVASTAYSARNNQESLTVRDRMNKVKKLFVPYMMPLLLVYVAEYTINQGVAPTLLFPLEESPFDEFRAFYPFYGFLYQLGVFISRSSTPWIRIHHLYLPSMLQIANLVLLTLHAMYFFLPSVYVVFIIVFWEGLLGGGVYVNCFAEIMENVPAEDREFSLGATTVSDSGGISIAGLLSIVMETKLCNYQVAHGRDWCQRISAQGQ
What is the function of this protein?
Involved in vacuolar transport and vacuole pH homeostasis.  Also required for cytokinesis (By similarity).
What are the official names of this protein?
Protein BTN1.
What is the protein family that this protein belongs to?
Belongs to the battenin family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: PROF3_TOBAC
Sequence: MSWQTYVDDHLMVDFEGQGQHLAAAAILGHDGSVWAQSPHFPKFKPEEITNIMKDFDEPGFLAPTGLFLAGIKYMVIQGEPGAVIRGKKGSGGITIKKTNQALIFGLYEEPVTPGQCNMVVEKIGDYLVDQGY
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin-3.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RK33_ATRBE
Sequence: MAKGKDVRVTVILECTSCVRNSVDKVSRGISRYITQKNRHNTPNRLELKKFCPYCYKHTIHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HCLS1_MOUSE
Sequence: MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEEHDILKKKELESGPKASHGYGGRFGVERDRMDKSAVGHEYVADVEKHSSQTDAARGFGGKYGVERDRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESLAEEKRKREEEEKAQQMARQQQERKAVVKMSREVQQPSMPVEEPAAPAQLPKKISSEVWPPAESHLPPESQPVRSRREYPVPSLPTRQSPLQNHLEDNEEPPALPPRTPEGLQVVEEPVYEAAPELEPEPEPDYEPEPETEPDYEDVGELDRQDEDAEGDYEDVLEPEDTPSLSYQAGPSAGAGGAGISAIALYDYQGEGSDELSFDPDDIITDIEMVDEGWWRGQCRGHFGLFPANYVKLL
What is the function of this protein?
Substrate of the antigen receptor-coupled tyrosine kinase.  Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells.  May also be involved in the regulation of gene expression (By similarity).
What are the official names of this protein?
Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DAPB_ASPNG
Sequence: MSSPRPSTSSTSSDSGLSVDTTAYPEESKYTSTAPGAGGLSDENRYRDVEEGEAGADEPFLPSAKKQAASGSRTSRLIWGLVILCVAGWLWGLVLFVTQNRSAQQSVSEALQSHESGAISGSSSSGKPVTLEQVLTGQWLPRSHAVSWIAGPNGEDGLLVEQGEDQGKGYLRVDDIRSRKGDATSQESRVLMEKAIVQVDGRTIFPVSTWPSPNLNKVLLLSEREKNWRHSFTGKYWIFDVATQTAQPLDPSNPDGRVQLAIWSPTSDMVAFVRDNNLYLRRLSSKEVVPITKDGGADLFYGIPDWVYEEEVFSGNSVTWWSGDGKYVAFLRTNETAVPEFPVQYYLSRPSGKRPPPGLEDYPEVREIKYPKAGAPNPVVSLQFYDVEKQEVFSIEAPDDFEDDDRIVIEIVWGTEGKILVRATNRESDVLKVFLFDTKARTSKLVRTENVADIDGGWVEPTQYTWFIPADPSNGRPHDGYLDTVIHEGYEHLGYFTPLDNSEPILLTQGEWEVVDAPTAVDLRKGIVYFISTKESPTERHLYQVNLDGSNLKPLTDTSKPGYYDVSFSHGTGYALLSYRGPSIPWQAIVNTETDELKYEETIEDNAGLARMVDSYALPTEIYQNVTIDGFTLQVVERRPPHFNPAKKYPVLFYLYNGPRSQTVDRKFSIDFQSYVASSLGYIVVTVDGRGTGFSGRKTRCIVRGNLGYYEAYDQITTANLWGEKPYVDETRMSIWGWSYGGFMTLKTLEQDAGQTFQYGMAVAPVTDWRHYDSIYTERYMHTPAHNPNGYDNTSITDMTALQQTVRFLVIHGASDDNVHIQNTLVLVDKLDLAGVQNYDLHFYPDSDHSINFHNAHRMVYERLSSWLVNAFNDEWHRIADPVPDDSMWEKVKRSLPMLVN
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: FLOWR_DROME
Sequence: MSFAEKITGLLARPNQQDPIGPEQPWYLKYGSRLLGIVAAFFAILFGLWNVFSIITLSVSCLVAGILQMVAGFVVMLLEAPCCFVCFGQVNEIAEKVESKPLYFRAGLYIAMAIPPIILCFGLASLFGSGLIFGTGVVYGMMALGKKASAEDMRAAAQQTFGGNTPAQTNDRAGIVNNAQPFSFTGAVGTDSNV
What is the function of this protein?
A calcium channel that regulates synaptic endocytosis and hence couples exo- with endocytosis.  Isoform A and isoform B are mainly required in the nervous system and necessary in photoreceptor cells.
What are the official names of this protein?
Calcium channel flower, 3L5.
What is the protein family that this protein belongs to?
Belongs to the calcium channel flower family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Upon fusion of the synaptic vesicle with the presynaptic membrane, protein is present in the periactive zones, where endocytosis is known to occur.
Protein: CYST_ECOLI
Sequence: MFAVSSRRVLPGFTLSLGTSLLFVCLILLLPLSALVMQLAQMSWAQYWEVITNPQVVAAYKVTLLSAFVASIFNGVFGLLMAWILTRYRFPGRTLLDALMDLPFALPTAVAGLTLASLFSVNGFYGEWLAKFDIKVTYTWLGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFCKVVLPELSPALVAGVALSFTRSLGEFGAVIFIAGNIAWKTEVTSLMIFVRLQEFDYPAASAIASVILAASLLLLFSINTLQSRFGRRVVGH
What is the function of this protein?
Part of the ABC transporter complex CysAWTP (TC 3. A. 1. 6. 1) involved in sulfate/thiosulfate import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Sulfate transport system permease protein CysT.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PDXS_HYPBU
Sequence: MKLIDSYAVLEKIRDLIYSLLEARDRAMENGLEVIPVRTATPLVRYGFISMLKGGVVMDVTNEQQAEIAEDAGAVGVMVLDKLPYDVRKAGGVARTADLNVIRAVMETITIPVSAKCRIGHYWEAKLLEEIGVDLIDESEVLTPTDEKAHIWKWEFRVPFVNGARSLPEALRRIWEGASMIRTKGEAGTGNVAEAVRHMKAVNRDIAVLRGYYKAGDIEAIRLYAKSNNVPFELALLTARLGRLPVVNFAAGGIATPADAALMMWLGADGVFVGSGIFKSRDPEQRAQAIVLATTYWDDPETVAEAQSMVSERNAMPGIDITRLKPEELLQIRGE
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: MARE1_COTJA
Sequence: MAVNVYSTSVTSDNLSRHDMLAWINESLQLTLTKIEQLCSGAAYCQFMDMLFPGSVALKKVKFQAKLEHEYIQNFKVLQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKEYDPVAARQGQETVAPNLVAPVMNKPKKPLGTGSAGPQRPIVAQRTPATPKGGTGMVKKAAGDDESAGLIEQINVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVEILYATDEGFVIPDEGAPQEEQEEY
What is the function of this protein?
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton.  Promotes cytoplasmic microtubule nucleation and elongation.  Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation.
What are the official names of this protein?
Microtubule-associated protein RP/EB family member 1.
What is the protein family that this protein belongs to?
Belongs to the MAPRE family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
Protein: F16PA_HELPS
Sequence: MDYKHFKGKHANIVIEIISLLEKGVKKAQEILEKPDAGSYTKLENSSGDTPIKADLALDKFLEENFLSLENVKSVFSEEKETPVTKENGSYLIAYDPLDGSSVMEANFLVGTIIGVYEKDYKAQNLAASLYVVFGHKIELVVALEEVYRYGFYQNKFHFIETIVLENKGKIIASGGNQKDFSSGLKKALEGFFAENYRLRYSGSMVADVHHVLIKKGGMFSYPQKKLRKLFEVFPLALMVEKAKGEAFYFDKGVKKRLLEQSVESYHEKSECYLASQHEAHILEKYLKGE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOB_ECOSE
Sequence: MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYCY2_CALJA
Sequence: MGLLLLLLILTPLLAAYCHPDFRLLEKAQQLLQSTGSPYSTNCWLCTSSSSKTPGRAYPASSREWTTIEAELHISYQWDPNLKGLIRLANSLLSKVKQDFPDIRKEPPIFGPIFTNVNLIGIAPICVTAKRKDGTNVGTLPSTVCNVTLTVDPNQQTYQKYAHNQFHHQPRFPKPPNITFPQGTLLDKSTRFCQGRPSSCSTRNFWFQPADYNQCLQIPNLSSTAEWVLLDQTRNSLFWENKTKGANQSQTPCVQVLAGMTIATSYLSTSAVSEFSGTSVTSLFSFHISTCLKTQGAFYICGQSIHQCLPTNWTGTCTIGYVSPDIFIAPGNLSLPIPIYGNFHFPRVKRAIHLIPLLVGLGIVGSAGTGIAGIAKASFTYSQLSKEIANNIEAMAKTLTTVQEQIDSLAAVVLQNRRGLDMLTAAQGGICLALDEKCCFWVNQSGKVQDNIRQLLNRASTLQEQATQGWLNWEGTWKWFSWVLPFTGPLVSLLLLLLFGPCLLNLITQFVSSRLQATKLQMKLNKRVHPRNSQESPF
What is the function of this protein?
Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.  Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.  The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain.  The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).
What are the official names of this protein?
Syncytin-2, ERV-FRD provirus ancestral Env polyprotein, Envelope polyprotein.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.
What are the subcellular locations of this protein?
Virion. SUBCELLULAR LOCATION: [Surface protein]: Cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. SUBCELLULAR LOCATION: [Transmembrane protein]: Cell membrane; Single-pass membrane protein.
Protein: MPPB_BOVIN
Sequence: MAAAAVARAVLFSAARRRLCGFTERLLIGGAAGRSLYFGGNRLRSTQAAAQVVLNVPETRVTCLENGLRVASEDSGLATCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSINRKDLVDYITTHYKGPRIVLAAAGGVSHDELLELAKFHFGESLSTHKGEIPALPPCKFTGSEIRVRDDKMPLAHLAVAVEAVGWAHPDTICLMVANTLIGNWDRSFGGGMNLSSKLAQLTCHGNLCHSFQSFNTSYTDTGLWGIYMVCEPATVADMLHVVQKEWMRLCTSVTESEVARAKNLLKTNMLLQLDGSTPICEDIGRQMLCYNRRIPIPELEARIDAVNAEIIREVCTKYIYDKSPAVAAVGPIEQLPDFNQICSNMRWLHD
What is the function of this protein?
Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (By similarity).  Preferentially, cleaves after an arginine at position P2 (By similarity).  Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (By similarity).
What are the official names of this protein?
Mitochondrial-processing peptidase subunit beta, Beta-MPP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: EX7S_STRGC
Sequence: MSKEKKFEENLADLEVIVQKLENGDVALEEAIAEFQKGMKLSKELQASLDKAEKTLVKVMQEDGTETEME
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_ECO24
Sequence: MAKEFGRPQRVAQEMQKEIALILQREIKDPRLGMMTTVSGVEMSRDLAYAKVYVTFLNDKDEDAVKAGIKALQEASGFIRSLLGKAMRLRIVPELTFFYDNSLVEGMRMSNLVTSVVKHDEERRVNPDDSKED
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RCAF1_CANLF
Sequence: MSGGRRKEEPPQPQLANGALKVSVWSKVLRSDAAWEDKDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCVINAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVIWIIFYTAIHYD
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261528).  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261528).  Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261528).  In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes (By similarity).
What are the official names of this protein?
GEL complex subunit OPTI, Obligate partner of TMCO1 insertase, Rab5-interacting protein, RIP5, Respirasome Complex Assembly Factor 1, RCAF1.
What is the protein family that this protein belongs to?
Belongs to the EMC6 family.