PharMolix/UniProtQA huggingface dataset:
Protein: EFG1_GEOMG
Sequence: MARLVPLEKTRNIGIMAHIDAGKTTTTERILYYTGVTHKIGEVHEGAATMDWMEQEQERGITITSAATTCNWGDHRINIIDTPGHVDFTIEVERSLRVLDGAVAVFCSVGGVEPQSETVWRQADKYGVPRIAFVNKMDRVGADFFRGVSMIRDRLKANPVPIQLPIGAEDTFKGVVDLVEMKAIVWDEESLGAKFHVEEIPADLQELAQEYHEKMVEEISSHDDALMEKYLGGEELTVDEVRAAIRNATIAIQICPVICGSSFKNKGVQNLLDSVVEYLPSPVDIPAIKGVDADSGAEIERKAADSEPFAALAFKIMTDPFVGQLCFIRVYSGVLNSGSYVYNSTKGKKERIGRLLKMHANKREEIKEVLAGDIAAAVGLKYTTTGDTLCPEDAPVILESIEFPEPVIAIAIEPKTKADQEKLGISLQKLASEDPSFRVRTDEETGQTIISGMGELHLEIIVDRLMREFKVEANVGKPQVAYRETVTKKVKVEGKFVRQSGGRGQYGHVWIEMEPQEPGKGYEFVDAIKGGVVPREYIPAVDKGIQEAMDTGVLAGFPCVDFKVSLVDGSYHEVDSSEMAFKIAGSMAFKEAAAKASPVLLEPIMSVEVVVPEEYMGDVIGDLNSRRGRIMGMEGRAGAQVVSAMVPLAQMFGYATDLRSATQGRATYTMTFDHYEQVPKSVSEEIIAKVKG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 1, EF-G 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY1_BORGP
Sequence: MIIAIDGPSASGKSSIARELGVKLGYKFISSGYLYRIITLIAQKFLMSSCDFISEDRLLNLILENDISFNDSSFFLNGENVESQILNDKIDFQVSFYSSYVGIRNIVNKKLREVVKFSNDNYIIEGRDITTIVFPESEFKIYLDASVKVRALRRYKQRNGNETLEELERTLKIRDDVDKRKQYGKLKLSKGVFYLDTSYKGLDDVCNIIIEKFNLKKVRER
What are the official names of this protein?
Cytidylate kinase 1, CK 1, Cytidine monophosphate kinase 1, CMP kinase 1.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GREA_ACICJ
Sequence: MQKFPMTGPGLQNLEAELRHLKSEERPAIIRAIAEARSHGDLSENAEYHSARERQSFIEGRIAELEEIISAAEVIDPSTLSGDTVKFGAHVELIDEESDKEVTYQIVGVHEADIKAGRISVTSPLAKSLIGKKPGDTVSVPAPGGDRSYEILAVRFG
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: TTCA_SINFN
Sequence: MELSRSSQREMMDVAVDAEDNAFDTGDHRLFARMPSSVSFNKLRKRLLRQVRQAFDGFGMLKGSKRWLVGVSGGKDSYSLLALLMDLKWRGLLPVELIACNLDQGQPNFPKHILPDYLASIGVRHRIEYRDTYSIVKEKVPTGATYCSLCSRLRRGNLYRIAREEGCDALVLGHHREDILETFFMNFFHGGRLASMPAKLLNDEGDLTVLRPLTYAAEDDLAKFAAAMEFPIIPCDLCGSQDGLERNAMKAMLADIERRMPGRKDTMLRALGHVNPSHLLDPKLFDFQSLSPEPKE
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_COLP3
Sequence: MNLADKVLAVNNDLPIRTDSPVHSGKVRSVYWLTATDSKRLIEEKGYDVPSDTSLAIMVISDRISAFDCIWSGENDMRGVPGKGAALNAISNHWFKMFKEQGLADSHILDIPHPFVWIVQKAKPVMIEAICRQYITGSMWRSYTKGERDFCGIELPEGLAKDSKLTSLLQTPSTKGILEGIPGVPAVDDVNITRKNIEDNFEAFNFKSVDDIARYEKLLTEGFDVISTALSKIDQVFVDTKFEFGYVKDVNGDDKLIYMDEVGTPDSSRIWDGEQYRAGKVVENSKEGFRQLLLNHFPDADILLNKDRMSEREALARDNKLPLSVLMDVSKTYTDIAEKITGNKIVLSDNPKAEIIAILREQYQLID
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: MRAY_ECOL6
Sequence: MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLVGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENOPH_MOUSE
Sequence: MVVVSVPAEVTVILLDIEGTTTPIAFVKDVLFPYIKENVKEYLQTHWEEEECQQDVSLLRKQAEEDAHLDGAVPIPVASGSDLQQMIQAVVDNVYWQMSHDRKTTALKQLQGHMWKAAFTAGRMKAEFFADVVPAVRRWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELIDGHFDTKIGHKVDSESYRKIADSIGCSTNNILFLTDVTVEASAAEEADVHVAVVVRPGNAGLTDDEKTYYNLITSFSELYLPST
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase, MASA homolog.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYY_ARCFU
Sequence: MDITEKLRLITRNAEEVVTEEELRQLIETKEKPRAYVGYEPSGEIHLGHMMTVQKLMDLQEAGFEIIVLLADIHAYLNEKGTFEEIAEVADYNKKVFIALGLDESRAKFVLGSEYQLSRDYVLDVLKMARITTLNRARRSMDEVSRRKEDPMVSQMIYPLMQALDIAHLGVDLAVGGIDQRKIHMLARENLPRLGYSSPVCLHTPILVGLDGQKMSSSKGNYISVRDPPEEVERKIRKAYCPAGVVEENPILDIAKYHILPRFGKIVVERDAKFGGDVEYASFEELAEDFKSGQLHPLDLKIAVAKYLNMLLEDARKRLGVSV
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_PHOPR
Sequence: MSFSAVILAAGKGTRMYSNVPKVLHTLAGKPMAKHVIDTCSDLGASHIHLVYGHGGDTMQQVLADEPVSWILQAEQLGTGHAVNQASSGLADNEKVLILYGDVPLISGDTLTNLLDAQPDGGIALLTVVLDNPVGYGRIVRRNGPVVAIVEQKDASEEQKLIKEINTGVMVANGGDLKRWLGQLKNENSQGEYYLTDIIAIAHDEGRAVEAVHPVNPIEVEGVNNRIQLARLERAYQAMQAERLLEQGVMLRDPSRFDLRGKLQCGTDVEIDVNVIIEGNVSIGNNVLIGTGCVLKDCEIDDNSVIRPYSVIEGATVGEDCTVGPFTRLRPGAELVGDSHVGNFVEMKKSRLGRGSKANHLTYLGDADIGDRVNIGAGTITCNYDGVNKFKTEIGDDVFVGSDTQLIAPVKIGKGATIGAGATINRDIGEGELVITRAPARTIKGWKRPVKQK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LONM_PICST
Sequence: MLRTSCTSSLRRVVGKYVVSPLVASQIRFATSSVRSQPYLLNSELTELPAQFKRYSSILLTEKPEGDVPESGPEPSGESGISEKSNVENDKHDGNDEIKPEAEKNEKDEIEKPEIDKDAIVETDGVSESSVENVSGSSSAAGGASAPPSGNSNNNNNNNNNNNDNDEPNEIVTNAGTGLYPPLLAIPMKDRPPLPGRPFAINITDPEVIRSIYTIIDKREPYFVLFHVKDPNEGDTDVINSKDSVYNIGVHCQIIRHTTPRPGVFNVLGYPLERCSLADLSTPSEKKGETETRKEGENFPTSYLKGLKVSYATVKPVKDEPFDKTSTDIKSLVESLKALLSKMGAKNPLEKLQIKEGTELVNDPPRFADFVGSTIHGDPKKIQEILESLNIQTRLSKALELLKVELKASLIKENTIHNLSTKADEYQTRLFIKEFIKELQKRAGIVESDDKKTSKFDERLKHLKMTEEALEAYNAEKAKMESQNEHSSELGVSERYLDWLTSIPWGIYSKDRFNIKQAREILDRDHYGLKDVKDRILEFISMGRVSGKVDGKILCLTGPPGTGKTSIAKSIAESLNRKYVRIAMGGIQDVHEVKGHRRTYVGSIPGRIISALKQAKTSNPLMLIDEIDKLDLSRSGGASSAFLEILDPEQNNAFVDNYIDVKVDLSKVLFVCTANYLGNISPPLRDRMEIIEVNGYTNNEKIEIAKRHLIPDAAKKAGLEGGHVVIETKTISRLIEKYCRESGLRNIKKLITRIFSKASLKIVEEVEAREGESKSKSEEAKSEAITGSVTEISVEDATVKAQSIEEPSVESASQKVDEAKPVESEELKSDEEEEEVVKLEIPDDIKLEITSANLKDYVGPEIYTRDRVYDIPPPGVATGLSYSTSGNGDALYIESILTHSIGSGSGHASIHVTGSLKDVMKESASIAYSFAKSYMVKNYPENRFFEAAEIHVHCPDGAIPKDGPSAGISFTSSLISLALQKPLPPTIAMTGEITVTGRVLAVGGLREKILGAKRYGCNTIIFPKDIENELEEIPEEVKEGVKFIPVEWYQDVFDEIFPNLSSDEGNEVWKEEFNKLDKKKASNKKK
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix.  May also have a chaperone function in the assembly of inner membrane protein complexes.  Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome.  Binds to mitochondrial DNA in a site-specific manner.
What are the official names of this protein?
Lon protease homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: KAIB_PROMA
Sequence: MSPRKTYILKLYVAGNTPNSMRALTTLREILQTDFKGVYALKVIDVLKNPQLAEEDKILATPTLAKILPPPVRRIIGDLSDRERVLIGLDLLFEELSESDFFSGSPDSEFSSDEGKS
What is the function of this protein?
May be a metamorphic protein which reversibly switches between an inactive tetrameric fold and a rare, thioredoxin-like monomeric fold (KaiB(fs)).  KaiB(fs) binds phospho-KaiC, and perhaps clock output effectors.
What are the official names of this protein?
Circadian clock oscillator protein KaiB.
What is the protein family that this protein belongs to?
Belongs to the KaiB family.
Protein: NDHJ_IPOPU
Sequence: MQSFLSVWLVKHGIIHRSLGFDYQGIETLQIKPEDWHSVAVILYVYGYNYLRSQCAYDVAPGGLLASVYHLTRIEYGVTRIEYGAYQPEEVCIKVFASRKNSRIPSVFWIWKSADFQERESYDMLGISYDNHPRLKRILMPESWIGWPLRKDYVAPHFYEIQDAH
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit J, chloroplastic, NAD(P)H dehydrogenase subunit J, NADH-plastoquinone oxidoreductase subunit J.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: YGL7_YEAST
Sequence: MQPISIKDVESDQGKVYIVNALKDLVCKCLLEFVDIQIESFMYPDDPKCFTRIFKGNKIVNEASDKDSKVRSYPSSLGVGHSALFPLIYIRQKTNSLRFLNDPKQLPTPLVDDMNAKFKGIIKVYENLIHLYHSYQTVDCNNMNQQKLLGDLVSRGNFMLDILHGYVTIASTIVRDSKDANILIDTVNRFIHDTILFHKRIIHNSNAYTEYHVMKRGMQRNQSEETLVELEFRILDVSDVNLDNEFDDFLQHRKTSLKITHRRVI
What are the official names of this protein?
Uncharacterized protein YGL117W.
Protein: G3PG_CRIFA
Sequence: MAPIKVGINGFGRIGRMVFQSMCEDNVLGTELDVVAVVDMSTDAEYFAYQMKFDTVHGRPKYTVEVAKSSPSAKKPDVLVVNGHRILCVKADRNPADLPWGKLGVDYVIESTGLFTDKAKAEGHVKGGAKKVVISAPASGGAKTIVMGVNQHEYNPATHHVVSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQKTVDGVSIKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTKGKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDAALKKASQTYMKGILGFTDEELVSSDFINDARSSIYDSKATLQNNLPGEKRFFKVVSWYDNEWGYSHRVVDLVRFMGAKDRSSSKL
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Glycosome.
Protein: ARSD2_ECOLX
Sequence: MKMLTVFDPAMCCSTGVCGSDVDQVLVNFSADVQWLKGRGVQIERYNLAHEPMSFVENEKAKAFLEASGAEGLPLLLLDGETVMAGRYPKRAELARWFGIPLEKVGLASTSCCGGKTSCC
What is the function of this protein?
Inducer-independent trans-acting repressor of the ars operon.
What are the official names of this protein?
Arsenical resistance operon trans-acting repressor ArsD.
Protein: UGL_BURCJ
Sequence: MKLLRYGPPGQEKPGILDAAGRIRDLSAHVPDLAGEVLSDAGLARLRAIDPATLPLVSGEPRIGACVGHVGKFIGIGLNYADHAAEAGMPVPKEPVVFGKWTSSICGPNDGIDIPKGSVKTDWEVELGVVIGAKCKDVDEARALDYVAGYCVVNDVSEREWQIERGGQWDKGKGFDTFGPIGPWLVTRDEVPDPQRLDLWLEIDGHRYQNGNTRTMVFTVAQLIAYLSTCMTLQPGDVITTGTPPGVGMGIKPSPVFLKAGQMVRLGIDGLGEQLQSTRHAQ
What are the official names of this protein?
Ureidoglycolate lyase, UGL, Ureidoglycolase, Ureidoglycolatase, Ureidoglycolate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the FAH family.
Protein: C83A1_ARATH
Sequence: MEDIIIGVVALAAVLLFFLYQKPKTKRYKLPPGPSPLPVIGNLLQLQKLNPQRFFAGWAKKYGPILSYRIGSRTMVVISSAELAKELLKTQDVNFADRPPHRGHEFISYGRRDMALNHYTPYYREIRKMGMNHLFSPTRVATFKHVREEEARRMMDKINKAADKSEVVDISELMLTFTNSVVCRQAFGKKYNEDGEEMKRFIKILYGTQSVLGKIFFSDFFPYCGFLDDLSGLTAYMKECFERQDTYIQEVVNETLDPKRVKPETESMIDLLMGIYKEQPFASEFTVDNVKAVILDIVVAGTDTAAAAVVWGMTYLMKYPQVLKKAQAEVREYMKEKGSTFVTEDDVKNLPYFRALVKETLRIEPVIPLLIPRACIQDTKIAGYDIPAGTTVNVNAWAVSRDEKEWGPNPDEFRPERFLEKEVDFKGTDYEFIPFGSGRRMCPGMRLGAAMLEVPYANLLLSFNFKLPNGMKPDDINMDVMTGLAMHKSQHLKLVPEKVNKY
What is the function of this protein?
Involved in the metabolism of aliphatic and aromatic oximes (PubMed:12970475).  Involved in the biosynthesis of both short-chain and long-chain aliphatic glucosinolates (PubMed:12509530).
What are the official names of this protein?
Cytochrome P450 83A1, CYPLXXXIII, Protein REDUCED EPIDERMAL FLUORESCENCE 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: VP4_ROTH5
Sequence: MASLIYRQLLTNSYSVDLHDEIEQIGSEKTQSVTVNPGPFAQTRYAPVNWGHGEINDSTTVEPVLDGPYQPTTFKPPNDYWFLISSNTDGVVYESTNNNDFWTAVIAVEPHVSQTNRQYILFGENKQFNVENNSDKWKFFEMFKGSSQGDFSNRRTLTSNNRLVGMLKYGGRVWTFHGETPRATTDSSNTADLNNISIMIHSEFYIIPRSQESKCNEYIKNGLPPIQNTRNVVPLSLSSRSIQYRRAQVNEDITISKTSLWKEMQYNRDIIIRFKFGNSVIKLGGLGYKWSEISYKAANYQYSYSRDGEQVTAHTTCSVNGVNNFSYNGGSLPTDFSISRYEVSKENSYVYIDYWDDSKAFRNMVYVRSLAANLNSVKCTGGSYDFRLPVGGWPIMNGGAVSLHFAGVTLSTQFTDFVSLNSLRFRFSLTVDEPSFSIIRTRTINLYGLPAANPNNGNEYYEMSGRFSLISLVLTNDDYQTPIMNSVTVRQDLERQLNDLREEFNSLSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDLTKSMATSVMKKFRKSKLATSISEMTNSLSDAASSASRSASIRSNLSTISNWTNTSKSVSNVTDSVNDVSTQTSTISKKLRLREMITQTEGMSFDDISAAVLKTKIDMSTQIGKNTLPDIVTEASEKFIPKRSYRVLKDNEVMEINTEGKFFAYKVDTLNEIPFDINKFAELVTDSPVISAIIDFKTLKNLNDNYGITRIEAFNLIKSNPNVLRNFINQNNPIIRNRIEQLILQCKL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: UNG_PSEP1
Sequence: MTDDDRIKLEPSWKAALRGEFDQPYMHQLREFLRGEYAAGKEIYPPGPLIFNALNSTPLGQVKVVILGQDPYHGPGQAHGLCFSVQPGVATPPSLVNIYKELQRDLNIPIPSHGYLQSWAEQGVLLLNTTMTVERANAASHAKKGWELFTDRIIQVVSEQCPNVVFLLWGAHAQSKQKLIDGTKHLVLKSVHPSPLSAYRGFIGCGHFSRTNSFLEQRGLGPIDWALPPL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_SYNR3
Sequence: MAVPKKKTSKGKRDQRHAHWKAKARVAARKALSAGKAVLSGRAQGFVYPMPEEDGEAES
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: CENPS_HUMAN
Sequence: MEEEAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNSLLKYITDKSEEIAQINLERKAQKKKKSEDGSKNSRQPAEAGVVESEN
What is the function of this protein?
DNA-binding component of the Fanconi anemia (FA) core complex.  Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429).  In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA.  Stabilizes FANCM (PubMed:20347428, PubMed:20347429).  In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428).  In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631).  As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917).  DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded.  Does not bind DNA on its own (PubMed:20347428, PubMed:20347429).
What are the official names of this protein?
Centromere protein S, CENP-S, Apoptosis-inducing TAF9-like domain-containing protein 1, FANCM-associated histone fold protein 1, FANCM-interacting histone fold protein 1, Fanconi anemia-associated polypeptide of 16 kDa.
What is the protein family that this protein belongs to?
Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
Protein: ATPG_LEPCP
Sequence: MAAGKEIRGKIKSVENTKKITKAMEMVAASKMRKAQERMRAARPYADKIRNITANLSRATPEYHHPFVVKNSGSGVVGMIIVTTDKGLCGGMNTNVLRLVTNKMRELDAAGTKVQAVAIGNKGLGFLNRIGAKVVSQATQLGDTPHLDKLIGPVKVLLDLYAEGKLDAVYICYTRFLNTMKQEPQVEQLLPLSDERLSQSAAEQQSHGWDYIYEPDAQAVIDNLMVRYAEALIYQSVAENMASEQSARMVAMKAATDNAGSLIGELKLVYNKTRQAAITKELSEIVSGAAAVG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SIAP_HAEIN
Sequence: MMKLTKLFLATAISLGVSSAVLAADYDLKFGMNAGTSSNEYKAAEMFAKEVKEKSQGKIEISLYPSSQLGDDRAMLKQLKDGSLDFTFAESARFQLFYPEAAVFALPYVISNYNVAQKALFDTEFGKDLIKKMDKDLGVTLLSQAYNGTRQTTSNRAINSIADMKGLKLRVPNAATNLAYAKYVGASPTPMAFSEVYLALQTNAVDGQENPLAAVQAQKFYEVQKFLAMTNHILNDQLYLVSNETYKELPEDLQKVVKDAAENAAKYHTKLFVDGEKDLVTFFEKQGVKITHPDLVPFKESMKPYYAEFVKQTGQKGESALKQIEAINP
What is the function of this protein?
Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid (N-acetyl-beta-neuraminate).  This protein specifically binds sialic acid with high affinity.  N-Acetylneuraminate (sialic acid) can then be incorporated into the lipooligosaccharides (LOS) as a terminal non-reducing sugar, protecting the bacterium from complement-mediated killing by normal human serum.
What are the official names of this protein?
Sialic acid-binding periplasmic protein SiaP, Extracytoplasmic solute receptor protein SiaP, N-acetylneuraminic-binding protein, Neu5Ac-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 7 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PUR9_BARHE
Sequence: MGVVAKNFPIPDLHRVRRVLLSVSDKTGIVAFAQALQTYNVELISTGGTAKVLMAAGLPVRDVAEVTGFPEIMDGRVKTLHPLIHGALLGVREDPSHAVAMEQYGIHGIDLLVVNLYPFEETVQSGADGQTILENIDIGGPAMIRAAAKNHVYTGVITAVSDYDAVLSELKQHDGCLSFSMRQQLAMRAYAHTAAYDTAIAAWFAKNLKIETPSWQSFSGHLKNVMRYGENPHQKAAFYRNGDKRFGVATAKLLQGKALSYNNMNDTDAAFELVAEFDPQNTAAVALIKHANPCGVAEGQTLKEAYLKALLCDNVSAFGGIIALNQPLDAECAEEVIKIFTEVIIAPDATMEAREIISGKKNLRLLLTGGVPDPRCGGFIAKTLAGGILVQSRDNVVVDDLKLQVVTKRAPSQEEMRDLQFAFRVVKHVKSNAIVYAKNSATVGIGAGQMSRVDSAKIAARKAEESAKRAGLTESLTKGSVVASDAFFPFADGLLAVAEAGATAVIQPGGSMRDEEVIAAADAQGLAMVFTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.