PharMolix/UniProtQA huggingface dataset:
Protein: UGPB_SHIFL
Sequence: MKPLHYTASALALGLALMGNAQAVTTIPFWHSMEGELGKEVDSLAQRFNAENPDYKIVPTYKGNYEQNLSAGIAVFRTGNAPAILQVYEVGTATMMASKAIKPVYDVFKEAGIQFDESQFVPTVSGYYSDSKTGHLLSQPFNSSTSVLYYNKDAFKKAGLDPEQPPKTWQDLADYSAKLKASGIKCGYASGWQGWIQLENFSAWNGLPFASKNNGFDGTDAVLEFNKPEQVKHIAMLEEMNKKGDFSYVGRKDESTEKFYNGDCAMTTASSGSLANIREYAKFNYGVGMMPYDADAKDAPQNAIIGGASLWVMQGKDKETYTGVAKFLDFLAKPENAAEWHQKTGYLPITKAAYDLTREQGFYEKNPGADTATRQMLNKPPLPFTKGLRLGNMPQIRVIVDEELESVWTGKKTPQQALDTAVERGNQLLRRFEKSTKS
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Binds G3P.
What are the official names of this protein?
sn-glycerol-3-phosphate-binding periplasmic protein UgpB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y098_RICPR
Sequence: MFKHVLLSIIIFLGINQNVYSINSNSYKTDDIIKIVIILGIVILIFSPAKFRIIVIGTILGLACAYFTYKYIIPIFIASLNAA
What are the official names of this protein?
Uncharacterized protein RP098.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EUPT_PHOSX
Sequence: MAPAIDSTVNDLQPNTPNPEKALSSQAQAFVRAYSEDGDSGGQSVLGAEDPLSPLNPRGERFNARAWAKNLAAVTRERGEGFRQVGISFQNVNVFGYGTPTDFQKNVGNVWLALPAMIRQLFAPKGGQTRIDILNHFNGLVRPGEMCVVLGPPGSGCSTFLKTISGHTSGLHVNPDAHFNYQGLSAKEMITAHRGDCIYTAEVDVHFPMLTVGETLTFAARARSQQHLPEGISRNNYCDQLRDVIMAMYGIRHTIHTKVGDDFVRGVSGGERKRVSVAEATLANAPFQCWDNSTRGLDSANAIEFCRTLRLQSEIFGQTCVVSMYQAPQTAYDLFDKVLLIYEGRQIYFGSTSKAKDYFVNLGFECPARQTTPDFLTSITFPAERIPRPDCQPPRTPDEFSQVWKNSLECKALQDEINEYNMEHPINGPDADTFRQLKQASQAQGQKVTSPFTLTYSQQVKLCMWRGWARFKADPWPAVWVMVGNTIMALIMSSLFYNMGQDTNSFYGRSVVLFMAILFNAFSSILEVMTLYAQRPIVEKQSRYAFYHPSAEAYASVLVDMPMKITSTISFNLVFYFMTNLNRAPGNFFFYLLVVFLIVLAMSGVFRFIGSLSRTEQQAMVPASVLMLALLIFTGFVVPVDYMLPWCRWINYVNPVAYGYEALMVNEFHGREFTCSTYIPEYANATSGTGACSVVGATPGNLFWRNVGIIIAMVIFNYLMYFIASEYVTAKKSRGEILVFRRGHTPSIPAKGSGDLEKLESGHATTVLERSDPSMVHKGEGFQGSVSVFHWNNVCYDLEIKGKPRRILDNVDGWIKPGTLTALMGVSGAGKTTLLDCLANRRVGVGIVTGEMLVDGKVCDQSFQRKTGYAQQQDLHLETSTVREALTFSAFLRQPHSIPKADKLTYVEEVIKLLAMQDYADAVVGVIGEGLNVEQRKRLTLGVELVAKPPLLLFVDEPTSGLDSQTSWAVLDLLEKLSKAGQSILCTIHQPSAMLFQRFDRLLFLAEGGKPVYFGEIGNDSSTLIDYFERNGAKPCLPGSNPAEWMLEAVGAAPSISSEGDWPEIWRSSPEYQSVHHELARLKAVDIDQLSADKPDPTSYNEFAAPLWQQLVVVTQRAFLQSWRSPSYIYSKITLCIATSLFIGLVFFNAPLSIQGLQNQMFAIFEVMSIVGQLVDQQMPNFLTQRSLYEVRERPAKTYSWMVFMLSQIVTELPWSTLASVFMWALFYYPIGFHKNAQAAGQGTERGALMWLLFWQFLVWVSTFTHMCISFVDSADDGGNIANFLFVLAFFFCGVLASPSQMPRFWIFLYRASPLSYWVSAVLSTGFANVQVTCTDKEYTAFDPPKGSTCGEYMAEYISRAGGYVKDPQATESCGYCTIKDTNVFLAAVSSDYDTRWRNFGILWVYIGFNIAAALALYWIARMPKGKKRL
What is the function of this protein?
ABC transporter; part of the gene cluster that mediates the biosynthesis of eupenifeldin, a bistropolone meroterpenoid that acts as an antitumor agent.
What are the official names of this protein?
ABC transporter eupT, Eupenifeldin biosynthesis cluster protein T.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YB9U_YEAST
Sequence: MFSSLFLSSALFFFSCLMASSRNLKLSLFSTHSSIEFRLNRRLVFPFEFSCAKTSDSSTRFCTNNSAANAVADIATLDVITYSGSHLAIFFTLDIGKTGAFSLTKLDIFFATRLTLACFYLLGQAVVKAINFA
What are the official names of this protein?
Putative uncharacterized protein YBR277C.
Protein: YIDC_SCHPO
Sequence: MNENEGISLGELETRPFSEGITRFTKEQAAYYAEQKEKDRIKALKIPYEDSKVREYLRRYGEPITYFGEDALARRQRLQQLMIEKSLEGDNPLDVDQGASENIEKETYVQGSHELLVARKKIALYSLEKAKLRLKKEREISEIPVPEIVLSGKSSIEHLQKAELMGSQIGGERPIAIVRFSNNGNHFASGSWGGQVKVWNSDNLSEVQLFRGHTDRVSGLDWYPLCQAWDADSEQLTLATGAADNTVCLWKASQSTPLLRLEGHLARVGRVAFHPSGDYLVSASFDTTWRLWDVHTGVELLMQEGHSEGIFSIACQPDGSLVSSGGNDAIGRIWDLRSGKSIMVLDEHIRQIVAMAWSPNGYQLATSSADDTVKIWDLRKVSLAHTIPAHSSLVSDVRYIESGVNRFIATSGYDGCVKLWNPLNCSLIKSMVGHEEKVMSVDGYGDRFISSGYDRTIKLWYP
What are the official names of this protein?
Uncharacterized WD repeat-containing protein C227.12.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_BRUSU
Sequence: MSDKAAGETKNGNGATTEPSLNILAQYVKDLSFESPGAPLSLRPREKAPSININVNVNANPLSETDFDVVLTLEAKAVDGKDILFNTELVYGGVFRIQGIPQEHMLPLLFIECPRLLFPFARQIIADATRNGGYPPLMIDPIDFAQMFQQRMAEEQAKSAVKS
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_CAMJJ
Sequence: MPKMKSVKSAVKRFKVGKNKIKRGSAFRSHILTKKPAKRMRDLRTAKYVHSTNVKAVEKMLGI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RPB3_YEAST
Sequence: MSEEGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVETNTTVLADEFIAHRLGLIPLQSMDIEQLEYSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDLVIVSNLMGRNIGHPIIQDKEGNGVLICKLRKGQELKLTCVAKKGIAKEHAKWGPAAAIEFEYDPWNKLKHTDYWYEQDSAKEWPQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPVDQVVVRGIDTLQKKVASILLALTQMDQDKVNFASGDNNTASNMLGSNEDVMMTGAEQDPYSNASQMGNTGSGGYDNAW
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft.  Seems to be involved in transcription termination.
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB3, RNA polymerase II subunit 3, RNA polymerase II subunit B3, B44.5, DNA-directed RNA polymerase II 45 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RF3_FRAP2
Sequence: MNDILKEIAKRRTFAIISHPDAGKTTITEKMLLFGNAIKTAGTVKAKKSGVHATSDWMEMEKERGISITTSVMQFPYNGKVVNLLDTPGHEDFSEDTYRTLTAVDSALMVVDAVKGVEDRTIKLMNVCRLRDTPIVTFMNKFDRDTRDPLELLDEVEDIMKIKCAPMNWPIGMGKFFKGVYDLYNDEVTLFEGGHGHEIHPYKKIKGLANAKDQIGADLFDDLEMEIDLVRGASHEFDQEAFLKGELTPVYFGTALANFGVKEMMDGFTTYAPEPQPRETNERLVNTDENKLTGFVFKIQANMDDKHRDRIAFFRICSGKYEKGMKIYHERTGKMMQVSKALTFMAGEREQVEEGYAGDIIGLHNHGSIQIGDSFTQGEKLKFKGIPNFAPEIFKRVKLNDPLKMKALQKGLVQLSEEGATQVFKPMISNDLVLGAVGVLQFDVVAQRLASEYNVKCSYEGVNVSLARWIFCDDEKKLNDFKKKYEVNLSYDGAGYLTYLAPTGVNLQLAQDKNPDIIFSATREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VRP_PINMG
Sequence: MQAVLLVVALFGAALADPPKQIHLPTPKVKRVEKLAHQEHAVNVVQAVPITKTVVRTVNVPKTLIQEVPIHVYTDLVLKSPVPRRKVIDIKKTVLQPHIRHVPVDQPYVVHRRVPVIHTKIVRQPRPVHRIVKIPKLKVVQKQLNRIIDVPQIVTKERIHRVIKPVPVERTRIQHVDVDVPMRVVVPEPVVQDRHTQSVETVPVPHDVVRKVKVPKTFVLKDLIPVPEKAGRHYSSDK
What are the official names of this protein?
Valine-rich protein, Alveoline-like protein.
Protein: RR15_HORVU
Sequence: MKKKGGRKILGFMVKEEKEENRGSVEFQVFSFTNKIRRLASHLELHKKDFSSERGLRRLLGKRRRLLAYLAKKNRVRYKKLIGQLNIREQ
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: S2538_NEOFI
Sequence: MSNNAAYAVTPVKTTSTSSRTTFHFAAGLCSGLTSSILLQPADLLKTRVQQSQKTASLLPTIKTILSSPHPIRGLWRGTLPSALRTGFGSALYFTSLNALRQGLAQTEASMAIAASSSDGKSRTSSSALPKLSNWGNLATGAVARTAAGFVMMPVTVLKVRYESDYYAYRSLYSAGRDIVRTEGVRGLFSGFGATAARDAPYAGLYVLFYEQLKRRLASVASSEQSEQPLKSTSSSSINFVSGGLAAGLATAITNPFDAVKTRLQLMPGKYGNMIRAVRLMIREDGVRSLFGGLGLRITRKALSSALAWTVYEELILRAEAHWAEKDKIDL
What is the function of this protein?
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix.  Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y2451_STAEQ
Sequence: MKHSKKLLLCISFLLITIFISGCGFINKDDSKETEIKKSFNKTLSMYPIKNLEDLYDKEGYRDEEFNKNDKGTWVITSSINIQQKGEGLKTRRMVLFMNRNTRTSKGKFMITEVKEKSDIGFQTRKKEYPVKLIDNKFIPSKQIKDEKIKKEIENFKFFSQYGNFKDLKDYKDGEVSYNPNAPNYSAKYQLSNNDYNVKQIRKRYDIPTEQAPKLLLKGTGDLKGSSTGSKNIEFTFVEKKGENIYFTDSVEYTPSGDDK
What are the official names of this protein?
Uncharacterized lipoprotein SERP2451.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RLMD_ALCBS
Sequence: MARRRKQLPETPEPASIETLSHDGRGIARRDGKTTFIDNALPGEEVMFKFTYMRRKFDEGKAVEIVTASPDRVTPPCEHSTLCGGCSLQHMSPEVQVSRKQAVLREQLAHFGGLEPEEWLAPLTGPVTGYRSKARMGVKYVEAKGETLVGFREKRNSFIAQLHTCEVLIPDVGHRIDELRTLMHGLESRSRIPQIELAAGDDDVALIIRHLDPLSEADQQALLGFCQNLGWHCYLQPGNESTVHRIWPQEGEQRLYYKHPSAGVELAFHPTDFTQVNAEINRKMVPLALDLLDISPDHTVLDLFCGLGNFTIPAAKRAGKVVGVEVSQAMVERGYENARRNSLENLEFHAWDLSQDVSGQAWARQTYDRILIDPPRTGALEMVKLMPRLGASKIVYVSCNPATLARDAGELMALGYRLKAAGVMDMFPHTTHVESIAVFEKMKKK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: FBX11_RAT
Sequence: MVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1.  The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells.  The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit.  Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity.  SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG.
What are the official names of this protein?
F-box only protein 11.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: KDPB_ECO27
Sequence: MSRKQLALFEPTLVVQALKEAVKKLNPQAQWRNPVMFIVWIGSLLTTCISIAMASGVMPGNALFSAAISGWLWVTVLFANFAEALAEGRSKAQANSLKGVKKTAFARKLREPKYGAAADKVPADQLRKGDIVLVEAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGTRILSDWLVIECSVNPGETFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATLWPFSAWGGNAVSVTVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGDVDVLLLDKTGTITLGNRQASEFIPAQGVEEKALADAAQLASLADETPEGRSIVILAKQRFNLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVEANGGHFPADVDQKVDQVARQGATPLVVVEGSRVLGVIALKDIVKGGIKERFAQLRKMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLIEVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAATYPQLNALNIMRLHSPDSAILSAVIFNALIIVFLIPLALKGVSYKPLTASAMLRRNLWIYGLGGLLVPFIGIKVIDLLLTVCGLV
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS6_KLUMA
Sequence: MKLNISYPINGTQKCVEIDDEHRVRVFYDKRIGQEVDGEAVGDEFKGYVFKIAGGNDKQGFPMKQGVLLPTRVKLLMAKGTSCYRPRRNGERKRKSVRGAIVGPDLAVLALVIVKKGDQEIEGVTNETVPKRLGPKRANNIRKFFGLTKEDDVRDYVIRREVTKGEKTYTKAPKIQRLVTPQRLQRKRQQKALKIKNAQAQREAAAEYAQLLAKRLAERKAEVRKRRASSLKAAE
What are the official names of this protein?
40S ribosomal protein S6, Ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS6 family.
Protein: DFSC1_CAEEL
Sequence: MNPHTNLNNVFDFPDLPMLLPKSEALSVTTDFSVPPVQQGAQQFHPPRNLGPQLARRWSCGDSQHADEPPASYYHNLGVALHNHFQMSNQHYLSDFDCPTTVSPISSAHETGQLPQLSPYDHIGNQDPHMFSPHAYGNSMIPDNSYFENASRSISAPNVGNSTLNPSLMSSDNAQSCGGRRRFRTNFTELQSTFLEDSFKESHYPDHKAKKYMADFLKIPEDRITVWFQNRRAKWRRKEHRQRDRTRNESFSGGSNSFDFACFSAQHPDDGPNAKHPNSFGIPNQPMSLDQFPMNTEQDFPEFPSLQEHQ
What is the function of this protein?
Transcriptional regulator which plays a role in the expulsion step of defecation by controlling enteric muscle-specific expression of exp-1 which is required for enteric muscle contraction.  Not required for exp-1 expression in the PDA neuron.  Also involved in controlling the length of the defecation cycle.
What are the official names of this protein?
Homeobox protein dsc-1, Defecation suppressor of clk-1.
What are the subcellular locations of this protein?
Nucleus. Cell projection, axon. Cytoplasm.
Protein: IRAK4_HUMAN
Sequence: MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
What is the function of this protein?
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.  Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374).  Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2.  Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1.  Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1.  Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex.  In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation.  Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation.  Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
What are the official names of this protein?
Interleukin-1 receptor-associated kinase 4, IRAK-4, Renal carcinoma antigen NY-REN-64.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_SHESA
Sequence: MGIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIEIDKGGSKLIKIRDNGSGIPKDELALALSRHATSKLHSLDDLEAILSFGFRGEALASISSVSRLTLTSRTAEQTEAWQAYAEGADMAVKVMPAAHPVGSTIEVVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIALVRGDIHFTLTHNGKIVRNCRPAMNEPQYLQRLTQVAGRQFADEALRVECQHDDLRLSGYLQSPWSTVLTDTHYFYVNGRLVRDRLVNHAVRQAFAQKAEVEQPGYVLMLDIDPHQVDVNVHPAKHEVRFHQSRYVHDYILQALQSALEEAGELGFERPFEPSSPQIRDEASLSETGAQTQTEHHAFELQSPESKTHSTWNEASRVDTSRAETSRESRIDSPLGERTRDIASARPYAGVQSNAYGSMAVPRESRSGSAGESRARAELPSKVAIASYGELLQTPSYSVQDKPYQPVLAMPAILNGQYWVLAQGQNLSLLPIQSVALATRSHEVETKLATGLIGQPLLMPVSIAADTDWPALLEEHETLIRQLGLELTIRYQQLIIKKVPPYLRDSQLAKVIPEWLQSLRFEAPAPNALAVWLAEQSLTGFTSAADIWAAYCQLTEEKRQQIADKAVSLPWQSWLEEQASE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: PURT_SALTI
Sequence: MTLLGTALRPAATRVMLLGAGELGKEVAIECQRLGIEVIAVDRYPDAPAMHVAHRSHVINMLDGEALRHVITEEKPHYIVPEIEAIATDTLRELEGEGLNVVPCARATQLTMNREGIRRLAAEELGLPTSTYRFADSEASFHDAVAAVGFPCIVKPVMSSSGKGQSFIRSAEQLAQAWEYAQQGGRAGAGRVIVEGVVKFDFEITLLTVSAVDGVHFCAPVGHRQQDGDYRESWQPQQMSELALKRAQEIARHVVLALGGHGLFGVELFVCGDEVIFSEVSPRPHDTGMVTLISQDLSEFALHVRAFLGMPIGAIRQYGPAASAVILPQLTSQNVTFDDVHAAVGAGVQVRLFGKPEIDGTRRLGVALATGENVEEAVIRAKKAASRVTVKG
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: YHBP_SHIBS
Sequence: METLITISRWLAKQHVVTWCVQQEGELWCANAFYLFDAQKVAFYILTEEKTRHAQMSGPQAAVAGTVNGQPKTVALIRGVQFKGEIRRLEGEESDLARKAYNHRFPVARMLSAPVWEIRLDEIKFTDNTLGFGKKMIWLRDSGTEQA
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: HMGX3_HUMAN
Sequence: MDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPNSKLSALTAVVPDIPGFRKILPRSDYIIIPKSSLQEDRSCPQLELCVAQNQMSPKGPPLVSNTAPETVPSHAGMAEQCLAVEALAEEVGALTQSGAVQEIATSEILSQDVLLEDASLEVGESHQPYQTSLVIEETLVNGSPDLPTGSLAVPHPQVGESVSVVTVMRDSSESSSSAPATQFIMLPLPAYSVVENPTSIKLTTTYTRRGHGTCTSPGCSFTYVTRHKPPKCPTCGNFLGGKWIPKEKPAKVKVELASGVSSKGSVVKRNQQPVTTEQNSSKENASKLTLENSEAVSQLLNVAPPREVGEESEWEEVIISDAHVLVKEAPGNCGTAVTKTPVVKSGVQPEVTLGTTDNDSPGADVPTPSEGTSTSSPLPAPKKPTGADLLTPGSRAPELKGRARGKPSLLAAARPMRAILPAPVNVGRGSSMGLPRARQAFSLSDKTPSVRTCGLKPSTLKQLGQPIQQPSGPGEVKLPSGPSNRTSQVKVVEVKPDMFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQSTLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRLQTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGYWAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPFFPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARAIRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVSVSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHYYLYNRLMDFLTSREIVNRQIHDIVQSCQPGEVVIRDTLYRLGVAQIKTETEEEGEEEEVAAVAE
What are the official names of this protein?
HMG domain-containing protein 3, HMG box-containing protein 3, Protein SMF.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHLG_ARATH
Sequence: MTSILNTVSTIHSSRVTSVDRVGVLSLRNSDSVEFTRRRSGFSTLIYESPGRRFVVRAAETDTDKVKSQTPDKAPAGGSSINQLLGIKGASQETNKWKIRLQLTKPVTWPPLVWGVVCGAAASGNFHWTPEDVAKSILCMMMSGPCLTGYTQTINDWYDRDIDAINEPYRPIPSGAISEPEVITQVWVLLLGGLGIAGILDVWAGHTTPTVFYLALGGSLLSYIYSAPPLKLKQNGWVGNFALGASYISLPWWAGQALFGTLTPDVVVLTLLYSIAGLGIAIVNDFKSVEGDRALGLQSLPVAFGTETAKWICVGAIDITQLSVAGYLLASGKPYYALALVALIIPQIVFQFKYFLKDPVKYDVKYQASAQPFLVLGIFVTALASQH
What is the function of this protein?
Involved in one of the last steps of the biosynthesis of chlorophyll a.  Catalyzes the esterification of chlorophillide a or b with a preference for geranylgeranyldiphosphate (GGPP) rather than for phytyldiphosphate (PhyPP).
What are the official names of this protein?
Chlorophyll synthase, chloroplastic, Polyprenyl transferase, Protein G4, AtG4.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Chlorophyll synthase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: GMHA_TRIL1
Sequence: MQSFIAKQLQDHLALFQKMEAELTAPVAELAERLIETFKIGNKLLIMGNGGSAADAQHFAGEIVSRFRIERPGLPAIALSTDTSIITAIGNDYGFERIFSRQVEALAVPGDAVIGISTSGNSPNVQKALEVARQAGCTTIGLLGKDGGSIKAVCDIPLIIPSNDTPRVQEGHIAVIHILCDLIEQGLFGIFAGEGR
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM263_HUMAN
Sequence: MNQTDKNQQEIPSYLNDEPPEGSMKDHPQQQPGMLSRVTGGIFSVTKGAVGATIGGVAWIGGKSLEVTKTAVTTVPSMGIGLVKGGVSAVAGGVTAVGSAVVNKVPLTGKKKDKSD
What is the function of this protein?
May play a role in bone development.
What are the official names of this protein?
Transmembrane protein 263.
What is the protein family that this protein belongs to?
Belongs to the TMEM263 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.