PharMolix/UniProtQA huggingface dataset:
Protein: TGT_ANOFW
Sequence: MTPIRYELIKTCKQTGARLGILHTPHGSFETPMFMPVGTLATVKTLSPEELKEMGAGVILSNTYHLWLRPGHDIVKEAGGLHSFMNWDRGILTDSGGFQVFSLSEFRRIEEEGVYFRNHLNGDQLFLSPEKAMEIQNALGSDIMMAFDECPPYPATYEYMKRSVERTSRWAERCLKAHQRPNEQGLFGIVQGGEFEDLRKQSAQDLVSLDFPGYAVGGLSVGEPKEVMNRVLEFTTPLLPANKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIGRNGTVMTSEGRVVIKNAKYARDFTPLDPNCDCYTCRNYTRAYIRHLIKCDETFGIRLTSYHNVYFLIKLMEQVRQAIREDRLGDFREQFFEQYGFNKPNAKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: RCCDA_DICDI
Sequence: MKIYSWGSGNLGQLGIGNTDDSVSTPTLVLPPDGKKDYEIVNDIVGGGCHSMMIIDNGDLYTFGSNDSGQLGINSNEQQQQQQQQQQQQQQQQQQQQQQQQYQTIPTILNYFKINSIKIKNCSGGWAHSLACDNNGNIYSWGSNSHGQLGIDTTCSLNSTLSTSNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSGGVIKKKIVLKKKKVERKNLNEPKLIEILFNNKIRIVSVSCGMRHSIALSSENDVYGWGCNKFGQLSNLIDGNSLKSNNNNNNINDIADPMVQDSPKLINFKNEIKIIQISCGFQHTLLLDINFKNVLSFGQNKFGQLGNGNFIDQSNPCVIDISSFILPTSTSKSLNDIKIKEIQCGWSNSCLLTNQDKLYICGRGEYGILGDNRDLSLDNSNSNQFKLLNSESFNENKIKNFSIGSEHILIQVYSNDNNNNNNNNNNIYSFGWNEHYQLGLCEPIIIGKDGDNKSFPQLLPSIKGNDKSLVKAGGGNSFFILP
What are the official names of this protein?
RCC1 domain-containing protein DDB_G0279253.
Protein: CA141_HUMAN
Sequence: MAEKILEKLDVLDKQAEIILARRTKINRLQSEGRKTTMAIPLTFDFQLEFEEALATSASKAISKIKEDKSCSITKSKMHVSFKCEPEPRKSNFEKSNLRPFFIQTNVKNKESESTAQIEKKPRKPLDSVGLLEGDRNKRKKSPQMNDFNIKENKSVRNYQLSKYRSVRKKSLLPLCFEDELKNPHAKIVNVSPTKTVTSHMEQKDTNPIIFHDTEYVRMLLLTKNRFSSHPLENENIYPHKRTNFILERNCEILKSIIGNQSISLFKPQKTMPTVQRKDIQIPMSFKAGHTTVDDKLKKKTNKQTLENRSWNTLYNFSQNFSSLTKQFVGYLDKAVIHEMSAQTGKFERMFSAGKPTSIPTSSALPVKCYSKPFKYIYELNNVTPLDNLLNLSNEILNAS
What are the official names of this protein?
Uncharacterized protein C1orf141.
Protein: ATPH_SACHY
Sequence: MNPLIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PROA_ECOBW
Sequence: MLEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSEIILNANAQDVADARANGLSEAMLDRLALTPARLKGIADDVRQVCNLADPVGQVIDGGVLDSGLRLERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAVILRGGKETCRTNAATVAVIQDALKSCGLPAGAVQAIDNPDRALVSEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIYVDESVEIAEALKVIVNAKTQRPSTCNTVETLLVNKNIADSFLPALSKQMAESGVTLHADAAALAQLQAGPAKVVAVKAEEYDDEFLSLDLNVKIVSDLDDAIAHIREHGTQHSDAILTRDMRNAQRFVNEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGIGDYTIRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_HELP2
Sequence: MKEKTPTPMKNIRNFSIIAHIDHGKSTLADCLIAECNAISNREMTSQVMDTMDIEKERGITIKAQSVRLNYTFKGEDYVLNLIDTPGHVDFSYEVSRSLCSCEGALLVVDATQGVEAQTIANTYIALDNNLEILPVINKIDLPNANVLEIKQDIEDTIGIDCSNANEVSAKAKLGIKDLLEKIITTIPAPSGDPNAPLKALIYDSWFDNYLGALALVRIMDGSINTEQEILVMGTGKKHGVLGLYYPNPLKKIPTKSLECGEIGIVSLGLKSVTDIAVGDTLTDAKNPTPKPIEGFMPAKPFVFAGLYPIETDRFEDLREALLKLQLNDCALNFEPESSVALGFGFRVGFLGLLHMEVIKERLEREFGLNLIATAPTVVYEVHLTDNSIKYVQNPSELPPENHIACIKEPFVRATIITPSEFLGNLMQLLNNKRGIQEKMEYLNQSRVMLTYSLPSNEIVMDFYDKLKSCTKGYASFDYEPIENREAHLVKLDVRVAGDVVDALSIIIDKNKAYEKGRALVETMKELIPRQLFEVAIQASVGNKIIARETIKSVGKNVTAKCYGGDITRKRKLLEKQKEGKKRMKAIGKVELPQEAFLAILKID
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TAT_HV1JR
Sequence: MEPVDPSLEPWKHPGSQPKTACTNCYCKKCCLHCQVCFTTKGLGISYGRKKRRQRRRPPQDSQTHQVSLPKQPSSQQRGDPTGPKESKKKVERETETDPDN
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: TIG_DESPS
Sequence: MDIKVEEVSKLTRKVIVTLPAGDVQPKIEAAYNKLKKEVKIKGFRRGKVPSAIIVKNYKDQVEAELSEKLVQENYFNAVEKEGLDPVTHPEIQVVKYNEDGSFTFEAHVDVRPDFELGNYKGLEIEKPAVAVADEDIDAEIAEMQKKAAALHVVDRPAVDGDMVTVDFQGFENGEALAQVKSDDHQVDLGAGSMGKDFEAKLVGMSKGEVADHQITFPENHPNVIIKGKTIDFKLSVKDVKERILADLDDEFAKDAGEEFNSMDELKASIRARRIKKLEESAEGVISDRLMQKLLEGYEFEVPTRLVAHESEQMIKQTEQQLQQSGLTLEAAGLSKEKLVEENVEVAAQRVRGDFLLKKIAEVEDIKVADEDMDRGFKRIGDMYNMTVAQVKEFFQSRDDLLPFMNELLNEKILAFLRSEAVMVEEKAVEATDVQKEGASE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: GLUC_RABIT
Sequence: HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
What is the function of this protein?
Glucagon plays a key role in glucose metabolism and homeostasis.  Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).
What are the official names of this protein?
Glucagon.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: P4K2A_XENTR
Sequence: MDETSPLVSPDRDQTDYSYQSQCSPGVPVCLSPNGRFSAVPGVVVRIPGSATSPIRGSAASGPSPPGSPCDRERQPLLERSQTRGAAAQAERERNKFPDDPEFAEVVKKAEKAIVRDILPERISQGSSGSYFVKNEQGEIIAVFKPKNEEPYGQLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVFLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVKGYKDADYWLRRFEADPLPENTNRQLQLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDSASARDDWVMVKEPVIKIAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKIQFSQEIKDLILPKISDPNFVKDLEEDLYELFKRDPGFDRGQFRKQIAVMRGQILNLTQALKDGKSPLQLVQTPPVIVETARSHQKSTSESYTQSFQSRKPFFSWW
What is the function of this protein?
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking.  Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
What are the official names of this protein?
Phosphatidylinositol 4-kinase type 2-alpha, Phosphatidylinositol 4-kinase type II-alpha.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Membrane raft. Endosome. Cytoplasmic vesicle. Cell projection, dendrite. Presynaptic cell membrane. Synapse, synaptosome. Mitochondrion. Membrane. Cell membrane. Perikaryon. Cell projection, neuron projection.
Protein: COG6_VANPO
Sequence: MEFIDYDTFGVSDTISTSAGDGALPEPVAILNLNALSFEKPDEHNEINLSELLVDRGTTDGGKNVNLNAKMSNYAKLSMESLHISGTSDNLSVNTLPSYIPDGNKESLDISKLVFQQKNQSLEATNMILNKKLSKILNDYSFSNYQSTSYLRKSLNSLEENKVALSLDENKLTNPGYIGTLARKTLKSDVETELLKEHLTVLEEFRPIVRKIKKLSSSIENIQNLGTSMLKESKENATGTEEPMFDRIKSLRKDIDNLKLKKELLLSIRDQYTLTQVEDDKISNGSVDEELFEIINKVMRIKEKTVFMLGLENPNAGKSLMHEVNNILQRLNRKLFNHLLDILYIFESGTNNVNEKFLSPNEKGVQTFQRSLIYLSNDLEYFNEFLKRVTSLRSKTVLDQFLSQFDFNSKDANPIMLSAYDPLRYIGDILANVYSLIANEADFVRSLFNFQEMQMENTPVSIIQKKDEFLDGLDSKLLNEIIQSLSNTCRIRIGQIIKFEDNPITNFEIVKLLELYKMMFERKGIKSNSSLINNLSALGVVSQEKLIECYSNFVNEIEKTTYVATEDFLPPEWLSDYLVKITDLFEAYEQHGGRESDTNEIIITDTFLEKVIKEPIENTLLKQLKEGFPLAKKEEQARTSLYTVQINCFDLIKSRIQPFASVIFSKDGEKNDVLKWISDKSEEVINQMLELQKKILFDKTGLGMYNNLLNMIFPISSVKDDLDLDMYYSLSENSLMNLDSINTNVHEKLNDYVPIALTDMQGNLLFKLTSPVIADKICDSCFSTLSEFYITFRKTLMHIYPEEEIKIKEILNFSEEEFKTLVGIE
What is the function of this protein?
Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking.  COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 6, COG complex subunit 6, Component of oligomeric Golgi complex 6.
What is the protein family that this protein belongs to?
Belongs to the COG6 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: UTS2B_CATCO
Sequence: GSNTECFWKYCV
What is the function of this protein?
Urotensin is found in the teleost caudal neurosecretory system.  It has a suggested role in osmoregulation and as a corticotropin-releasing factor.
What are the official names of this protein?
Urotensin-2B, Urotensin IIB, U-IIB, UIIB.
What is the protein family that this protein belongs to?
Belongs to the urotensin-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DEF2_CLOPE
Sequence: MAVKKIVQIGHEALKKVSEPVKDVNEVKGLIQDLKDTLATVEGIGLAAPQIAVNKRVVYINFGDGENEYVLINPEVTGVSKETYEDYEGCLSYVMHEGLVERPRAVRIQALNEKGELKVYEAQDLLARCFLHEIDHLEGIMYVDRAKEMYELVEK
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 2, PDF 2, Polypeptide deformylase 2.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: HOA3_COMTE
Sequence: MELKGKKITVHDMTLRDGMHPKRHLMTLEQMKSVAQGLDAAGVPLIEVTHGDGLGGASVNYGFPAHSDEEYLSTVIPLMKQAKVSALLLPGIGTVDHLQMAHELGVTTIRVATHCTEADVSEQHITAARKLGMDTVGFLMMAHMNSAEGLVKQAKLMEGYGANCVYVTDSAGYLLPDQVKERIAAVRAALKPETELGFHGHHNLAMGVANSIAAVEAGANRIDAAAAGLGAGAGNTPMEVLVAVCERMGIETGVDVWKIQDVAEDLVVPLMDFPIRVDRDALTLGYAGVYGSFLLFAKRAEKKYGIPARDLLVELGRRGMVGGQEDMIEDTALTMARARGIKVAA
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 3, HOA 3, 4-hydroxy-2-keto-pentanoic acid aldolase 3, 4-hydroxy-2-oxopentanoate aldolase 3.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: NADA_NEIMA
Sequence: MQTAARRSFDYDMPLIQTPTSACQIRQAWAKVADTPDRETADRLKDEIKALLKETNAVLVAHYYVDPLIQDLALETGGCVGDSLEMARFGAEHEAGTLVVAGVRFMGESAKILCPEKTVLMPDLEAECSLDLGCPEEAFSAFCDQHPDRTVVVYANTSAAVKARADWVVTSSVALEIVSYLKSRGEKLIWGPDRHLGDYICRETGADMLLWQGSCIVHNEFKGQELAALKAEHPDAVVLVHPESPQSVIELSDVVGSTSKLLKAAVSRPEKKFIVATDLGILHEMQKQAPDKQFIAAPTAGNGGSCKSCAFCPWMAMNSLGGIKYALTSGRNEILLDRKLGEAAKLPLQRMLDFAAGLKRGDVFNGMGPA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGJ_METMA
Sequence: MKQIEGGICAVRGVSAYGIKPGKMGIAVIRAEGPAAGVFTRNKVVAAPVTLSRERIETEHRLSAVIANSGNANAFTGDDGFLDAMEMASMVAENLGLDPDNVAVASTGVIGRRLDVSFIKEHLPEVLEGLGSSPECSRAAAKAIMTTDRALKESAVELDCGVRIGAIAKGSGMIEPNMGTMLCFAYTDAKVPADVLDAALKIAVDKTFNMVVVDGDTSTNDMVLFTSTCKSGVKPCLDCLDDFEEGLVCVFTDLAKKMAKDGEGATKLIEARVTGAKKYEDARLVAKTIVRSPLVKSAIFGKDPNWGRVVAAAGYSGAELEQERLTLSFSGGGEEVELVKAGEISTASDLSLLKKIMANDEIIINLDLAMGEESATAWGCDLTYDYVRINAEYTT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_YERPY
Sequence: MESIIQQINQLRTSLRHHEHQYHVLDAPEIPDAEYDRMMQQLRDLEAQHPELVTNDSPTQRVGAAPLDAFEQVEHEVPMLSLDNVFDEESYLAFDKRVHDRLKTAEPLTFCCELKLDGLAVSLLYENGELVRAATRGDGTTGENITANVRTIRAIPLRLHGDNVPRRVEVRGEVFMPQAGFEQLNEEARRKGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGLLDGGELPRSHIQCLMQFKAWGLPVSERVKLCTGSDQVIAFYRQIEQDRAGLGFDIDGVVIKVDDLVLQEQLGFVARAPRWATAFKFPAQEQITQVREVEFQVGRTGAITPVARLEPVQVAGVIVSNATLHNADEIERLGLRIGDTVIVRRAGDVIPQVVGVVMEQRPDDTKEITFPSQCPVCGSDIERVEGEAVARCTGGLFCAAQRKEALKHFVSRRALDVDGMGDKIIEQLVEKQYVENPADLFQLTAGKLTGLDRMGPKSAQNLIAALEKAKQTTFARFLYALGIREVGEATAANLAAHFRTLDNLRAADIETLKSVPDVGEVVAKHVMNFLSEEHNQKVIEELEKVVSWPEPQQIVVEEIDSPFAGKTVVLTGSLTILSRDEAKDRLTALGAKVSGSVSKKTHLVIAGEAAGSKLAKAQELGIKVIDEAEMIRLLGE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RBL_DIOEL
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVSPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIESVVGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTSYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGAPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREMTLGFVDLLRDDFIEKDRSRGIFFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREACKWSPELAAACEVWKEIKFEFKPVDTLDL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GDL76_ARATH
Sequence: MKDNLERAKLMVSSTVFSWLLLCLFAVTTSVSVQPTCTFPAIYNFGDSNSDTGGISAAFEPIRDPYGQGFFHRPTGRDSDGRLTIDFIAERLGLPYLSAYLNSLGSNFRHGANFATGGSTIRRQNETIFQYGISPFSLDMQIAQFDQFKARSALLFTQIKSRYDREKLPRQEEFAKALYTFDIGQNDLSVGFRTMSVDQLKATIPDIVNHLASAVRNIYQQGGRTFWVHNTGPFGCLPVNMFYMGTPAPGYLDKSGCVKAQNEMAMEFNRKLKETVINLRKELTQAAITYVDVYTAKYEMMSNPKKLGFANPLKVCCGYHEKYDHIWCGNKGKVNNTEIYGGSCPNPVMAVSWDGVHYTEAANKHVADRTLNGLLTDPPVPITRACYRQ
What are the official names of this protein?
GDSL esterase/lipase At5g14450, Extracellular lipase At5g14450.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted.
Protein: NS1_I72A4
Sequence: MDSNTVSSFQVDCFLWHVRKQVVDQELGDAPFLDRLRRDQKSLRGRGSTLGLNIEAATHVGKQIVEKILKEESDEALKMTMASTPASRYITDMTIEELSRDWFMLMPKQKVEGPLCIRIDQAIMDKNIMLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSFPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKTLQRFAWGSSNENGRPPLTPKQKR
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: GSKIP_MACFA
Sequence: METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYDFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS
What is the function of this protein?
A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets.  The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively.  Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B.  During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity).  May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity).
What are the official names of this protein?
GSK3-beta interaction protein, GSKIP.
What is the protein family that this protein belongs to?
Belongs to the GSKIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COXX_PROMA
Sequence: MVSSTSQIISTSPSRDDVVPSRKKVTLPPWLEVAKPRLIPLLLATTLGGMALSEGWPLPSPRLACTLGGGALAAAAAGALNCLWEQDLDGRMKRTSSRALPAGKLSPSAVFTGAISCTLAAAALLVSGVNCLAAGLSLLGLCSYVLLYTAFLKPRTSQNIVIGGVAGAIPPLVGAAAATGHIGLSGWWLFALVMVWTPAHFWALAILLKDDYRSVGIPMLPVVKGSVFTAKAIAQYGWATVLLSCFGVFALPEGGALYGILLVPFNVRLLQMVRRLAADPEDLQRAKGLFRWSILYMFGICLLLVVSRSTLADQFHNQAIYLFTNMGSVFSIA
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PIN4_YEAST
Sequence: METSSFENAPPAAINDAQDNNINTETNDQETNQQSIETRDAIDKENGVQTETGENSAKNAEQNVSSTNLNNAPTNGALDDDVIPNAIVIKNIPFAIKKEQLLDIIEEMDLPLPYAFNYHFDNGIFRGLAFANFTTPEETTQVITSLNGKEISGRKLKVEYKKMLPQAERERIEREKREKRGQLEEQHRSSSNLSLDSLSKMSGSGNNNTSNNQLFSTLMNGINANSMMNSPMNNTINNNSSNNNNSGNIILNQPSLSAQHTSSSLYQTNVNNQAQMSTERFYAPLPSTSTLPLPPQQLDFNDPDTLEIYSQLLLFKDREKYYYELAYPMGISASHKRIINVLCSYLGLVEVYDPRFIIIRRKILDHANLQSHLQQQGQMTSAHPLQPNSTGGSMNRSQSYTSLLQAHAAAAANSISNQAVNNSSNSNTINSNNGNGNNVIINNNSASSTPKISSQGQFSMQPTLTSPKMNIHHSSQYNSADQPQQPQPQTQQNVQSAAQQQQSFLRQQATLTPSSRIPSGYSANHYQINSVNPLLRNSQISPPNSQIPINSQTLSQAQPPAQSQTQQRVPVAYQNASLSSQQLYNLNGPSSANSQSQLLPQHTNGSVHSNFSYQSYHDESMLSAHNLNSADLIYKSLSHSGLDDGLEQGLNRSLSGLDLQNQNKKNLW
What is the function of this protein?
Involved in normal G2/M phase transition of the mitotic cell cycle.  In association with RAD53, also involved in checkpoint control in response to DNA damage.
What are the official names of this protein?
RNA-binding protein PIN4, Psi inducibility protein 4.
What are the subcellular locations of this protein?
Cytoplasm.