Protein: CHRY1_GIBZE
Sequence: MAPPAAVSPLFVPQVGAPTDFHGLEPQWDTVGVECSGLTNKALANWLHKERHSHLSLIQAAWALCLRGYTGSEDVSFTCLGPERNYCCHVSPTQPVRSLFDLQHVESIGQNRTTFWDAISVVLTHEDLIEVTNPSAMFDLAVCFSQRVEAHLPSIKVYYRSSKVMSAMAEMIAATVAKSIEEIVAKIDSQINDLELCSDLDINRLARWNILSNAQDPIPQPIHRVISQNSTLHPTSIAVSAWDGDFTYRELDRLATGLAIWLQHLGIVGPEVFVPLVFDKSKWAVVAQLAVLKAGGAYFFINPSHPVQYSRELCSSLNPLVAVCSANHSGIAKELVCEAIALGDSVRELLESIPVDDTPGSPTVNISTSNAMYITFTSGTTGKPKGIITEHSAFYCMAVANAKSLQINNTTRMLQFASYSFDVSNRDTLVTLMFGGRVCIPSESDRLNNLAGFMRDHEVNLASLTPSMASTLSPSSCPSLRGLVLGGEPMTESHISTWSKHVQLFNAYGVSESTGIAALASNIKSGVSPSNIGYGCGSRLWVVAIDQPDKLAPIGALGELVIEGPSISRGYLDDKARTDQHFTSDPTWKKRIYQEYGSRQSGKRTFRTGDLVRYNLDGSLQLAGRRDHQVKVNGQRLELTAVEHHISACPQVLEAGFGHVAVVAVKAGNSGSTKLVAFLGRDTSRETCTPAQMVPEQLKDMDGLRSDLEGFLLLDLPSYMVPSEFVFLQHMPLTTSNKLNRLLLQNTAAQALAVDHDEQLNGHDLSDGEAPSTDDERILAETWAKILGIKESTISRNDSFFRRGGDSMAAIRMVASLREAGFVISVSDIFKTSILSELALLMVQADDKSTSTLPAPFSMLEDSQKTIQSIATESGLLVDDIEDAYPCTHMQQGLLALTAQNSRAYIGTYFWQLASGVDMDRFKQAWQDVWQHNPILRTRAVQTPEGLLQVVVRADMPWELVSSVTGFSTKIDINEGPLARFYLSADTFRLDIHHALFDEWSLDLLLAQVQQAYAGEALQMKPFSPFVRHILQQDHLSSEKFWRQQFSSLEVEHFPPTASKVGDTTKTNVLERDLPLDAGMSTKYTISSVVRLAWAILLWHQTGSEDVVFGATVSGRNASIDGIDQISGPTLASLPVRIKLPTGSSVQDGLAEVQDQFVNMIPHEQTGLSRIRQYSNEAAEACNFQNLLVVQPHEQKVDSAVFRSSTGGAASSDNTTAFASYPLVLTCRPDEGRVNFKAAFDSDLITSETIEGLLRQLSHVVRQIMTSESVAIRDISTVPPQDMEKLQMWNETVPKAVDICVHDRIRDLSKSQPDALAVHSMDLDLTYQQVEDYSNHFASHLISQGVTQGDFVPVLIERSPWAPVIMLAVLKTGAAFVLLDLSHPIQRLRTMCSMIDAKILVAFEQTRHIGEGLSLPITTFEPVEYLERQHQVCGTLPPIVSPHLDSPACVVFSSGSTGVPKGIVLPHGAIATSAAVMREQGNLTATSRVFHFASFAFDISIGEILFTLAAGACICVPHEQERRDNPGKAAGDLKATWALLTPSVINLFDPSDVPTLKTLGSCGEPLTSQIVDIWAHRLNLFAMYAPAECTVISHIGRVLPETHPSHIGRSFGAASWVVDPTDHNRLVPIGTIGELLVEGPVVSTGYLKDKARSDLVFVENPSWLSQFRSSCGRMYKTGDLVRQTPDGSLQFLGRKDDQVKLHGQRLEVGEVEHCLMSVCEDIKAVAVECVKVANQNNRAVLVAFIAPHTEGAWGQVASEAEGGDVQWVASPNEEFYSTIETMDTSARDQLPSYMVPAYFIPVAHIPLSLSGKINRRLLRETFSASISKNLDQYQLRTNTVEVDGTPETAHDREIQEIFAKVLSLDAQSVPMNGNFFSMGGDSISAMAASTLARRRGIDLAVATIFTHQVLSKISLACAPVDGETTKAGEHTEGQAGNASNGGHITLDKLPHHIPRDVLENVIEASPATEFQAMTLYNFYSRYLWIALPDGVDEERLKAAYNSLVQKHSILRTVFYTNADGSIVQLTLRDMPVALTHYTDVDDMEKHCADDSLSMGVPIDGNPGIQAQLLKLKDSRKILALRLPHALFDGMSLSTICDDLNSAYKGQEMSPCGQFSDHVRQVWEKRRPETYQVWKDVLQDTPITVMDSESLPVAKKTASAQVSDEPQLVTATLETGPISTPRNSTTATLVKLAWAITLSKLFTLGQNDNSLGDVVFGQVVHGRVLGIPHEDRIIGPCLNIIPVRVHFPSSPEKHDLLSQVQQQHVQTMAVQNLGLGEITRNCTTWESGTRFGSFIRFQNFTNSQESTCDFDGHACETGLYSLPNRPSKTADVLVAPKGSRLSIAMTVSSEVMDEEAADYVVRYFGDVMESLSRDEEACSYLC
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398).  Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable).  If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable).  This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable).  The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable).  A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable).
What are the official names of this protein?
Nonribosomal peptide synthetase chry1, NRPS chry1, Chrysogine biosynthesis cluster protein 1.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.