PharMolix/UniProtQA huggingface dataset:
Protein: LPLA_VIBCM
Sequence: MTKTRILLSDSTDPWFNLAVEDTIFRSMPADQRVLFLWRNADTVVIGRAQNPWRECKTDRMEQDKVKLARRQTGGGAVFHDLGNTNFTFMAGKPEYDKEVSTKIVLAGLQKLGIHGVANGRNDLVLEDEQGIRKFSGSAYRETLDRGFHHGTLLLSADLNRLADYLNPDLKKLQAKGITSVKSRVINLNTVKADIEHQQVCEAIMQAYCEHYQQQVEPELISPQSFFDLPGFEQKFAQQSSWDWNFGQTPPFTHHMDERFSWGGVEVYLEVERGTIVQATIFSDMLDPYPMEQLALRLSGLTYNKTALEPCLAQLMQELPQYQLPLEEFQRWFIDQID
What is the function of this protein?
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
What are the official names of this protein?
Lipoate-protein ligase A, Lipoate--protein ligase.
What is the protein family that this protein belongs to?
Belongs to the LplA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ELMO1_MOUSE
Sequence: MPPPSDIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGTDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRYIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN
What is the function of this protein?
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.  Acts in association with DOCK1 and CRK.  Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases.  May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).
What are the official names of this protein?
Engulfment and cell motility protein 1, Protein ced-12 homolog.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Protein: RS3_CHLFF
Sequence: MGQKGCPIGFRTGVTKKWRSLWYGNKQEFGKFLIEDVKIREHLRKKPSCQGAAGFVVRRMSGKIEVTIQTARPGLVIGKKGAEVDLLKEELRKLTGKEVWVEIAEIKRPELNAKLVADNIARQIERRVSFRRAMKKAMQSVMEAGAIGVKIQVSGRLAGAEIARSEWYKNGRVPLHTLRADIDYATASAETTYGIIGVKVWINLGEKTSTANASAGSAVSTAQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: COXX_BRUC2
Sequence: MSLVEKNTASEDAFALSEATARDYLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISILCIAVGAGASGALNMWYDADIDAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGLMVNWLAAALLAFTIFFYAVIYTMWLKRSTPQNIVIGGAAGAFPPMIGWAAATGEITWDSLVLFMIIFLWTPPHFWALSLFTTNDYEAARIPMMPNVKGELSTRRQALFYAVLMAPVGVLPWVMGFAGMFYGVVSTLLGLAFVYYAWRLWAADSQPQMLAAARKLFRFSLLYLAGIFAVLLFEALTFKLLAAFGVF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NCPR_MUSDO
Sequence: MSAEHVEEVVSEEPFLGTLDIALLVVLLVGATWYFMRSRKKEEAPIRSYSIQPTTVSTVSTTENSFIKKLKASGRSLVVFYGSQTGTAEEFAGRLAKEGLRYRMKGMVADPEECDMEELLQMKDIPNSLAVFCLATYGEGDPTDNAMEFYEWITNGEVDLTGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGATRVFELGLGDDDANIEDDFITWKDRFWPSVCDFFGIEGSGEEVLMRQFRLLEQPDVQPDRIYTGEIARLHSMQNQRPPFDAKNPFLASVIVNRELHKGGGRSCMHIELDIDGSKMRYDAGDHIAMYPINDKILVEKLGKLCDANLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCSDEKDKEFLRNMASITPEGKEKYQNWIQNSSRNIVHILEDIKSCRPPIDHICELLPRLQPRYYSISSSSKLYPTNVHITAVLVQYETPTGRVNKGVATSYMKEKNPSVGEVKVPVFIRKSQFRLPTKSEIPIIMVGPGTGLAPFRGFIQERQFLRDGGKVVGDTILYFGCRKKDEDFIYREELEQYVQNGTLTLKTAFSRDQQEKIYVTHLIEQDADLIWKVIGEQKGHFYICGDAKNMAVDVRNILVKILSTKGNMNESDAVQYIKKMEAQKRYSADVWS
What is the function of this protein?
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes.  It can also provide electron transfer to heme oxygenase and cytochrome B5.
What are the official names of this protein?
NADPH--cytochrome P450 reductase, CPR, P450R.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: NDK_SHEON
Sequence: MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGENAVLAHREILGATNPAQAAPGTIRADFAQSIDENAAHGSDSLASAEREIAYFFSAEELCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_LEIXX
Sequence: MTDTLPSTFTASLAEVDPEIAEVLQLELGRQRDYLEMIASENFVPRAVLESVGSVLTNKYAEGYPGRRYYGGCEYVDIAEQLAIDRAKSLFGAEYANVQPHSGASANAAVLSAIATPGETILGLELAHGGHLTHGMKLNFSGKLYNAVAYGVDPETFLVDMDAVRDRALEHKPQVIIAGWSAYPRQLDFAAFRAIADEVGAKLWVDMAHFAGLVAAGLHPSPVPYADVVSSTVHKTLGGPRSGFIVSRDTELAKKLNSNVFPGQQGGPLMHVIAAKATAFKLAATDEFKDRQARTIRGAQLLAERLTAADSRASGVDVLTGGTDVHLVLADLRTSELDGQQAEDILHEVGITVNRNAVPFDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIALALRPGADTRALRARVDALTAAFPLYPGLAPSAS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPY_CAVPO
Sequence: YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY
What is the function of this protein?
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
What are the official names of this protein?
Neuropeptide Y, NPY.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
Protein: SYK_SALEP
Sequence: MSEQNAQGADEVVDLNNEMKARREKLAALREQGIPFPNDFRRDRTSDQLHAEFDAKEAEELEALNIEVSVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILGAKGKLFKTKTGELSIHCTELRLLTKALRPLPDKFHGLQDQEARYRQRYLDLISNDESRNTFKTRSKILAGIRQFMVARGFMEVETPMMQVIPGGASARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMELYMAYADYKDLIELTESLFRTLAQDVLGTTQVPYGDEVFDFGKPFEKLTMREAIKKYRPETDMADLDNFDSAKAIAESIGIHVEKSWGLGRIVTEIFDEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVNAKAAGDDEAMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_LEVBA
Sequence: MTTKGILGKKVGMTQVFTDAGELIPVTVVEATPNVVLQVKTMENDGYNAIQLGYQDKREVLSNKPEQGHVAKANTTPKRFIREFTDVELGDYKVADEVKVDTFQAGDIVDVTGVTKGHGYQGNIHKDGQSRGPMAHGSRYHRRPGSLGAIINRVFPGMKLPGRMGNKQVTIQNLVIVKADVENNVLLIKGNVPGANKSLVTVKSAVRPPRPKQSEK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ENCP4_PYRFU
Sequence: MENNNIMSQVKEIIEAAIKELEDDGFEPDIILAGPIFIRYLPEDVRLKVYEIEELGSDAIIADSKYLGQIKKAAKRISIDPLLQEKEWEKIIEEIPTQE
What is the function of this protein?
May be the encapsulin shell protein in a type 4 A-domain encapsulin nanocompartment system.  Its cargo may be upstream glyceraldehyde-3-phosphate dehydrogenase (AC P61879).
What are the official names of this protein?
Putative type 4B encapsulin shell protein PF1875.
What is the protein family that this protein belongs to?
Belongs to the encapsulin family. Family 4B subfamily.
What are the subcellular locations of this protein?
Encapsulin nanocompartment.
Protein: JTX2A_CHIFL
Sequence: MDYAFIVFLVCFVSGTLGNRRRAKRDVDEVTSGINQLVNQLNNVQQDTAAIKSALEELKTEVSASPSTVSQVSEVVNTVGSSLTKFTSGDAFNIVSGCLDLLSTVASTFGGPYGIAISAVISLVSSILSLFAGDGFDSATRKVIEEAFKTHRDQELRDSVNGARRTFNDVIAFLKGASKHGNVTEQELEVISKGVPLTKLSDTLGILESRINRGSTSTDAAEAERTVEFIFLYLQLATMRDTLITNFILILKQVPAADTYANAVSISLDANKESVRETIDFLHNMEAKNAVCGAYYYPIYHSEMTKSILSFAKFFGLPDPPRNTFGGVYRVQNRYWPTWYICKESYMGNHMFRGCSNVRSPSVQIRALENGYQKINLRGKNMYITKHAQGWAWGTADNDPGEQGYFVFVPLKSGYYMISTKKWPNYFVYMESSASGYIRSWNHNPGLQGHWRIL
What is the function of this protein?
The fraction containing this toxin and CfTX-A shows potent hemolytic activity (PubMed:24403082).  This fraction causes minor effects on the cardiovascular system of anesthetized rats (at 25 ug/kg), since it has no significant effects on heart rate but produces relatively small increases in mean arterial pressure (PubMed:24403082).
What are the official names of this protein?
Toxin CfTX-A, Toxin A, TX-A.
What is the protein family that this protein belongs to?
Belongs to the jellyfish toxin family. Type II subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms a membrane channel in the prey.
Protein: RL14_BEUC1
Sequence: MIQQESRLKVADNTGAKEILCIRVLGGSGRRYAGIGDVIVATVKDAIPGGNVKRGDVVKAVVVRTAKERRRPDGSYIRFDENAAVLLKSDGEPRGTRIFGPVGRELRDKKFMRIVSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: AIRSR_SALTY
Sequence: MQVDKTSFTPLYKQLFFIICQQIQNGSLPLGSQLPTQKEIARSYNVSLIVVKQAWSELINAGIISSQRGSGSVVCSVPEGVSYGHTFRGITRDLQDASVAIENRILEIAPRRARDAQADGLSLPAQHHYLYISRIRCLNNRPFNHEKIYLDLSFFPGLELTPQALEHTSLYSLLNVTSDSAIEKVEAILPSADLCEKLQIAANKPLLSVARQTFQAGKDSPFEYCRYYVLSEYFGEIHYH
What is the function of this protein?
Represses the expression of the STM4065-STM4067 operon.
What are the official names of this protein?
HTH-type transcriptional repressor STM4068.
Protein: SFH6_ARATH
Sequence: MSGPVDRFAIPCFEGILSSDEKKERKSDFENSEDERRTRIGSLKKKAINASTKFKHSLKKKRRKSDVRVSSVSIEDVRDVEELQAVDEFRQALVMEELLPHKHDDYHMMLRFLKARKFDIEKAKHMWADMIQWRKEFGTDTIIQDFQFEEIDEVLKYYPHGYHSVDKEGRPVYIERLGKVDPNKLMQVTTLDRYIRYHVKEFERSFMLKFPACTIAAKKYIDSSTTILDVQGVGLKNFTKSARELITRLQKIDGDNYPETLHQMFIINAGPGFRLLWSTVKSFLDPKTTSKIHVLGCKYQSKLLEIIDSSELPEFLGGACTCADQGGCMLSDKGPWKNPEIVKMVLHGGAHRAKQVVKVLNSDGKVIAYAKPSYPWIKGSDTSTAESGSEAEDIVVSPKAVKSYSHLRLTPVREEAKVGSGETSFAGSFAGYDEYVPMVDKAVDATWKVKPTAINRAPSKGAHMPPNVPKDHESFSARVLVTFMAFVMAILTFFRTVSNRVVTKQLPPPPSQPQIEGSAAAEEADLLNSVLKKLTELEEKIGALQSKPSEMPYEKEELLNAAVCRVDALEAELIATKKALYEALMRQEELLAYIDRQEAAQHQKKNKRKQMFCF
What is the function of this protein?
Required for transport of secretory proteins from the Golgi complex.  Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity).
What are the official names of this protein?
Phosphatidylinositol/phosphatidylcholine transfer protein SFH6, Protein SEC FOURTEEN HOMOLOGS 6, AtSFH6.
What is the protein family that this protein belongs to?
Belongs to the SFH family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Protein: RS16_PHEZH
Sequence: MLKIRLARGGAKKRPYYSIVIADSHSPRDGRFIEKVGSYNPLLKKDDPNRIVVKQERIQEWLGKGAQPTDRVARELSKLGITQWTAGNNPKKGEPGQKAKERAEERAQREADRAAAAAEAAAAPAEEAPAEEAPAEEAAAEAAPEAAAAEEAPAAEAAAEEAAPAAEEAAPAEGEEQA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: LRC8D_HUMAN
Sequence: MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDFALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFANGI
What is the function of this protein?
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200).  The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731).  Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731).  LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471).  Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731).  Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity).  VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122).  Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309).
What are the official names of this protein?
Volume-regulated anion channel subunit LRRC8D, Leucine-rich repeat-containing protein 5, Leucine-rich repeat-containing protein 8D, HsLRRC8D.
What is the protein family that this protein belongs to?
Belongs to the LRRC8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029).
Protein: ISPF_BACC7
Sequence: MFRIGQGFDVHEFAEGRPLIIGGITIPHEKGLIGHSDADVLLHTIADACLGAIAAGDIGKHFPDTDPAFKDADSAVLLQKVWEFVREQGYELGNLDCTIIAQKPKMAPHIESMRKRISELLETSIDNINVKATTTEKLGFTGREEGIASQAVVLLQKK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: PCP_SYMSP
Sequence: MVRGARKAIAVGVAVAVACGLQKHLNFVPGPRHAAPVAAAAASMMMAPAAFADEIGDAAKKLGDASYSFAKEVDWNNGIFLQAPGKFQPLEALKAIDKMIEMGAAADPKLLKDAAEAHHKAIGSISGPNGVTSRADWDAVNAAIGRVVASVPKAKVMAVYDSVTAITDPGVPAYMKSLVNGPDAEKAYQGFLEFKDVVEKNQVATASAPAVVPSGDKIGEAAKALSDASYPFIKDIDWLSDIYLKPLPGKTAPETLKAIDKMIVMGAKMDGNLLKAAAEAHHKAIGSIDATGVTSAADYEAVNAAIGRLVASVPKTTVMDVYNSMAGVVDSSVPNNLFSKVNPLDAVAAAKGFYTFKDVVEASQR
What is the function of this protein?
Water-soluble antenna for capture of solar energy in the blue-green range.  Peridinin is an asymmetric carotenoid.
What are the official names of this protein?
Peridinin-chlorophyll a-binding protein, chloroplastic, PCP.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS17_STAAW
Sequence: MSERNDRKVYVGKVVSDKMDKTITVLVETYKTHKLYGKRVKYSKKYKTHDENNSAKLGDIVKIQETRPLSATKRFRLVEIVEESVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: SPIKE_IBVD2
Sequence: MLERSLLLATLLSALCSANLFGNNSYVYYYQSAFRPPDGWHLHGGAYEVVNVFTESSNAGTTGCTVGAIYWSKNFSAASVAMTAPQNGMSWSTEQFCTAHCNFTDFVVFVTHCYKSSHGSCPLTGLIPQNHIRISAMKNSSLFYNLTVAVTKYPRFKSLQCVNNMTSVYLNGDLVFTSNETKDVSAAGVHFKAGGPITYKVMREVKALAYFVNGTAQDVILCDGSPTGLLACQYNTGNFSDGFYPFTNSSLVKEKFIVYRESSVNTTLELTNFTFSNVSNATPNTGGVQTIQLYQTSTAQSGYYNLNFSFLSSFIYKASDYMYGSYHPSCKFRLETINNGLWFNSLSVSLGYGPIQGGCKQSVFANRATCCYAYSYNGPSLCKGVYRGELTKSFECGLLVFVTKTDGSRIQTRNEPFTLTQHNYNNITLDRCVEYNIYGRVGQGFITNVTNYAINYNYLADGGMAILDTSGAIDIFVVQGEYGLNYYKVNPCEDVNQQFVVSGGKLVGILTSRNETGSQPLENQFYIKIINGTRRSRRSITGNVTNCPYVTYGKFCIKPDGSISTIVPKELEHFVAPLLNVTENVLIPDSFNLTVTDEYIQTRMDKVQINCLQYVCGNSLECRKLFQQYGPVCDNILSVVNSVGQKEDMELLHFYSSTKPSGFNTPVLSNVSTGEFNISLLLTPPSSASGRSFIEDLLFTSVESVGLPTDDAYKKCTAGPLGFLKDLACAREYNGLLVLPPIITAEMQTLYTSSLVASMAFGGITSVGAIPFATQLQARINHLGITQSLLLKNQEKIAASFNKAIGHMQEGFRSTSLALQQIQDVVNKQSSILTETMASLNKNFGAISSVLQDIYQQLDSIQADAQVDRIITGRLSSLSVLASAKQAEYYRVSQQRELATQKINECVKSQSIRYSFCGNGRHVLTIPQNAPNGIVFIHFTYTPESFVNVTAIVGFCVNPANASQYAIVPANGRGIFIQVNGSYYITARDMYMPRDITAGDIVTLTSCQANYVSVNKTVITTFVDNDDFDFDDELSKWWNDTKHELPDFDEFNYTVPILDIGSEIDRIQGVIQGLNDSLIDLETLSILKTYIKWPWYVWLAIAFATIIFILILGWLFFMTGCCGCCCGCFGIIPLMSKCGKKSSYYTTFDNDVVT
What is the function of this protein?
Acts as a viral fusion peptide after S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the gammacoronaviruses spike protein family.
What are the subcellular locations of this protein?
[Spike protein S2]: Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers may be transported to the plasma membrane, where they may mediate cell-cell fusion. SUBCELLULAR LOCATION: [Spike protein S1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers may be transported to the plasma membrane, where they may mediate cell-cell fusion. S1 is not anchored to the viral envelope, but associates with the extravirion surface through its binding to S2.
Protein: ADPRS_HUMAN
Sequence: MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEPDPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVFQKS
What is the function of this protein?
ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (PubMed:21498885, PubMed:30830864, PubMed:33769608, PubMed:30045870, PubMed:29907568, PubMed:34321462, PubMed:30401461, PubMed:33186521, PubMed:34019811, PubMed:33894202, PubMed:34479984, PubMed:34625544).  Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:28650317, PubMed:29234005, PubMed:33186521, PubMed:34625544, PubMed:30045870, PubMed:34019811).  Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802, PubMed:33186521, PubMed:34625544).  Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (PubMed:16278211, PubMed:33769608).  Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:16278211).  Also hydrolyzes free poly(ADP-ribose) in mitochondria (PubMed:22433848).  Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (PubMed:17075046, PubMed:21498885).  Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (PubMed:21498885).
What are the official names of this protein?
ADP-ribosylhydrolase ARH3, ADP-ribose glycohydrolase ARH3, ADP-ribosylhydrolase 3, O-acetyl-ADP-ribose deacetylase ARH3, Poly(ADP-ribose) glycohydrolase ARH3, [Protein ADP-ribosylarginine] hydrolase-like protein 2, [Protein ADP-ribosylserine] hydrolase.
What is the protein family that this protein belongs to?
Belongs to the ADP-ribosylglycohydrolase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Mitochondrion matrix. Note=Recruited to DNA lesion regions following DNA damage; ADP-D- ribose-recognition is required for recruitment to DNA damage sites.
Protein: GLPD_STAAC
Sequence: MALSTFKREHIKKNLRNDEYDLVIIGGGITGAGIALDASERGMKVALVEMQDFAQGTSSRSTKLVHGGLRYLKQFQIGVVAETGKERAIVYENGPHVTTPEWMLLPMHKGGTFGKFSTSIGLGMYDRLAGVKKSERKKMLSKKETLAKEPLVKKEGLKGGGYYVEYRTDDARLTIEVMKRAAEKGAEIINYTKSEHFTYDKNQQVNGVKVIDKLTNENYTIKAKKVVNAAGPWVDDVRSGDYARNNKKLRLTKGVHVVIDQSKFPLGQAVYFDTEKDGRMIFAIPREGKAYVGTTDTFYDNIKSSPLTTQEDRDYLIDAINYMFPSVNVTDEDIESTWAGIRPLIYEEGKDPSEISRKDEIWEGKSGLLTIAGGKLTGYRHMAQDIVDLVSKRLKKDYGLTFSPCNTKGLAISGGDVGGSKNFDAFVEQKVDVAKGFGIDEDVARRLASKYGSNVDELFNIAQTSQYHDSKLPLEIYVELVYSIQQEMVYKPNDFLVRRSGKMYFNIKDVLDYKDAVIDIMADMLDYSPAQIEAYTEEVEQAIKEAQHGNNQPAVKE
What are the official names of this protein?
Aerobic glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.