PharMolix/UniProtQA huggingface dataset:
Protein: HIS7_MYCMM
Sequence: MTATETGTAVRRARIERRTRESDIVIDLDLDGTGQVDVDTGVPFFDHMLTALGSHASFDLTVRTKGDVEIEAHHTVEDTAIALGQALGQALGDKKGIRRFGDAFIPMDETLAHAAVDVSGRPYCVHTGEPDHLQHTTIAGNSVPYHTVINRHVFESLAMNARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_BUCAI
Sequence: MNNHIDIFNIPISKINLLDLNRQNLKYFLISLGAKNFCTEQVMSWIYNYYCDDFNKMLNISIKTRKKLYEKSYIFASEFIEEKISYDGTIKWITDINNQKIETVYMPEKKRSTLCVSSQIGCSLKCHFCATGQEGFQRNLKVSEIIAQIWQANKRLKEKNIKKNITNIVFMGMGEPLLNLKNVVSALTIILDEYGFGLSKRRVTLSTSGIVPALDKLRNMIDVSLAISLHAPNDFIRNIIMPINRKYNISSVLSSALKYFKYSNANRGGITIEYVMLDRINDSNENARQLSVLLSKIPSKINLIPWNSFSGPSFLCSNTDRINMFANILRKKGFTTTIRKNRGEDINAACGQLTGIITNYFKK
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_HAES1
Sequence: MSKRKKLLVMAGGTGGHVFPAIAVAQYLQKQDWDICWLGTRDRMEAKLVPKHGIPIEFIQISGLRGKGLITLLKAPFVILRAVLQARKIIKKYQPDVVLGMGGYVSGPGGVAAKLCNIPVVVHEQNAVLGLTNSLLAKIATRVLQAFPNTFPNAEVVGNPVREAFFSVPMPQERFNTTCETLKVLVVGGSQGAHILNTILPEVLAQLPNRLEIVHQVGSGSVENVTALYHDKVNLTQESVQITEFIDDIAQAYAWADIVICRSGALTVCELAAVGTPAIFVPFQHKDKQQYLNAKYLADVGAAYIVEQHELDAEKIAQLLKNVDKEKLLEMAEKAKNMSTPLSTQRVAEVIMDTVKT
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PYRG_LAWIP
Sequence: MKTKFIFITGGVLSSLGKGLSAASIGALLTSRGMTVTIQKLDPYINIDPGTMNPYQHGEVYVTDDGAEADLDLGHYERFLGTSLSQKNNSTSGAIYYKVISKERRGDYLGATVQVIPHITDEIKSTILSLAKSSIDNNTPDIAIIEIGGTIGDIEGLPFLEAIRQLQTDLGRQNCLYIHLTLVPYLGTAGEHKTKPTQHSVKELRSIGIQPNIILCRCEKPIPDDIKAKISLFCDVEKDAVFSAADINNIYELPLKFYTEGLDQKITSFLNLPTKQANLKPWEQLVNTINNPKGKVTITIVGKYVGLTEAYKSLHEALCHGGIANEITVDLQYVNSEIITEDNVNEIFKGVDGILVPGGFGSRGIEGKIESIRYARQKNIPFFGICLGMQCAVIEFARNVAGIEKANSEEFNPVAADKVIYLMKEWYDFRNNAIEYRDSLCDKGGTMRLGSYPCTLIKNTKAFKAYQTDSIEERHRHRYEFNNIYRDQFAEKGMIFSGTSPDNTLVEIIELLNHPWFIGCQFHPEFKSYPMKPHPLFKDFIHAACNHNKQ
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: RL3_YERPG
Sequence: MIGLVGKKVGMTRIFTEDGVSIPVTVIEIEANRVTQVKSLENDGYRAVQVTTGAKKANRVTKPEAGHFAKAGVEAGRGLWEFRLPEGQEFTAGQEISVEIFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGHMGDERVTVQSLDVVRVDAERNLLLVKGAVPGATGGNLIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: GCH1_VIBVY
Sequence: MSGLSESAQLVKQALEKRGLETPMVPNQFSREEKKEKIEHHMREILSLLELDLTDDSLEETPRRIAKMYVDEVFSGLDYQNFPKITVIENKMNVSEMVRVKEITLTSTCEHHLVTIDGKAAVAYIPRGKIIGLSKINRIVRFFAQRPQVQERMTQQILVALQTLLESDDVAVTIDATHYCVKSRGVMDATSETTTTALGGIFKSNPATRAEFLHGLR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: RBL_MORAL
Sequence: VGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEDMMKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDFVEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPELAAACEVWKEIKFEF
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DRKD_DICDI
Sequence: MEGSFQFNKSKQTNNNSSLDSNNIINDNINNNLNFENNNNNNNNNNNNNNNNNNNNNNNNTNNNNTTNDTSKTSANSTSTEDDEEDILGNRKKDTTGSRVLPMDTSLTGAAEPSKKRKNTQDDSEVEVQYHPQKRASFSLNISPTQLQNDLSLNIFNVSNSNNNNNSNNNNNNNNNNNNNNNKINNNSNLILNSSVDSTTSSNNNNNKNSNDNQQPQQQPEEIEGELNRERQERDKMLHEEAEIEQYKYGDGEEGENYEIMVTPHHRTSFGHITSANSDETTNNESGSPINSRKMVTDEEDPHSSHNEDHQSDQDNHGQFMNDEHQSTDDDQNKSDNEKESESARNSGDLQQKVHNSKDESTVSTPQHIFNNGNGEGEEEDDDDEEYDVPLRIQTVANNKSTKLSLSNCWLKVIPTDVWSILELRDLDLSANQLKKVSKSIGLLVHLKRLRLNHNQLTALPKELYSLPRLTTLYLNNNNFKVVPKEINRLTSLKTLDLSFNQITDISPQTNLHQMTNLVELRLRYNQLSSLPQNMLESNHLQVLWLEGNRLPLNKAILKKSPSEILSFLRGYKPPNKKVNDKVINKAHVNPALPPIDTASTIAVAQVFAQKELDTKKRKKENLDDFKKQHIETELKLKQLEEELQIANAKATKFEEEASLLQQQFNNPNTPTGPSLNLPSILLNQPHLGWDQQQQQQQQQSPNVSTPPISTSPVLTGGQQVVNGISQISLLSPTQQINNPPSPVTQFNQASPQHNNNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNGSPQQPHVNNNNNNNIQQNKDHQFPVPTIPAKIIEVEKPFEWEVPLSEIAIGARIGRGGYGQVFRGSWRGTEVAVKMLFNDNVNLKLISDLRKEVDLLCKLRHPNIVLFMGACTEPSSPCIVTEYLSRGSLANILLDESIEMDWGLRLQLGFDCARGMTYLHSRNPIIIHRDLKTDNLLVDDSWQVKVADFGLATVKSHTFAKTMCGTTGWVAPEVLAEEGYTEKADVYSYAIVLWELLTRLIPYAGKNTMQVVRSIDRGERLPMPAWCPPKYAALMNRCWETDPTHRPSFPEILPIMEGMISEFQKEKKESIAQGRPIPYVGPPEKDPSNKQPPQNMATTIQQQLAQQQPQQLLEQQILLQVQQQAQLQHLQQQLEQQQKLQQQLQQQIAHPNNPNNFYFQQQLQQQQFQQQLQQHQQHFQQQQQQQQQQQQQQQQQQQQQQQQLQQTGSPIDNRLNYNFNNSNNSDIQPMQQENNYRMNINDKK
What are the official names of this protein?
Probable serine/threonine-protein kinase drkD, Receptor-like kinase D.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Protein: CLCB_PSEPU
Sequence: MKIEAIDVTLVDVPASRPIQMSFTTVQKQSYAIVQIRAGGLVGIGEGSSVGGPTWSSECAETIKVIIETYLAPLLIGKDATNLRELQHLMERAVTGNYSAKAAIDVALHDLKARSLNLPLSDLIGGAIQQGIPIAWTLASGDTQRDIAIAEEMIERRRHNRFKIKLGVRSPADDLRHIEKIIERVGDRAAVRVDINQAWDENTASVWIPRLEAAGVELVEQPVARSNFDALRRLSADNGVAILADESLSSLASAFELARHHCVDAFSLKLCNMGGVANTLKVAAIAEASGIASYGGTMLDSSIGTAAALHVYATLPTMPFECELLGPWVLADTLTQTQLEIKDFEIRLPSGPGLGVDIDPDKLRHFTRAG
What is the function of this protein?
Highly active toward chlorinated substrates but retains diminished activity toward the non-chlorinated substrates.
What are the official names of this protein?
Chloromuconate cycloisomerase, Muconate cycloisomerase II.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Protein: Y4323_CITK8
Sequence: MNLQHHFLIAMPALQDPIFRRSVVYICEHNEDGAMGIIINKPLENLQIEGILEKLKITPEPRDPAIRLDKAVMLGGPLAEDRGFILHTPPSRFSSSIRISDNTVITTSRDVLETLGTPEQPSEVLVALGYSSWDKGQLEQELMDNAWLTAPADLNILFKTPIADRWRDAAKLIGIDILTMPGVAGHA
What are the official names of this protein?
UPF0301 protein CKO_04323.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: AATC_BOVIN
Sequence: MAPPSIFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDSQPWVLPVVRKVEQRIANDSSINHEYLPILGLAEFRTCASRLALGDDSPALQEKRVGGVQCLGGTGALRIGAEFLARWYNGTNNKDTPVYVSSPTWENHNGVFIAAGFKDIRSYHYWDAAKRGLDLQGFLNDLEKAPEFSIFVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGSLEKDAWAIRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVAKEPDSILRVLSQMEKIVRITWSNPPAQGARIVARTLSDPELFNEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITEQIGMFSFTGLNPKQVEYLINEKHIYLLPSGRINMCGLTTKNLEYVATSIHEAVTKIQ
What is the function of this protein?
Biosynthesis of L-glutamate from L-aspartate or L-cysteine.  Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system.  Acts as a scavenger of glutamate in brain neuroprotection.  The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis.  Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide.  Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST).  Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
What are the official names of this protein?
Aspartate aminotransferase, cytoplasmic, cAspAT, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PR15A_RAT
Sequence: MAPSPRPQHVLHWKEAHSFYLLSPLMGFLSRAWSRLRGPEVSEAWLAETVAGANQIEADALLTPPPVSENHLPLRETEGNGTPEWSKAAQRLCLDVEAQSSPPKTWGLSDIDEHNGKPGQDGLREQEVEHTAGLPTLQPLHLQGADKKVGEVVAREEGVSELAYPTSHWEGGPAEDEEDTETVKKAHQASAASIAPGYKPSTSVYCPGEAEHRATEEKGTDNKAEPSGSHSRVWEYHTRERPKQEGETKPEQHRAGQSHPCQNAEAEEGGPETSVCSGSAFLKAWVYRPGEDTEEEEDSDLDSAEEDTAHTCTTPHTSAFLKAWVYRPGEDTEEEDDGDWDSAEEDASQSCTTPHTSAFLKAWVYRPGEDTEEEDDSENVAPVDSETVDSCQSTQHCLPVEKTKGCGEAEPPPFQVAFYLPGQKPAPPWAAPKLPLRLQKRLRSFKAPARNQDPEIPLKGRKVHFSEKVTVHFLAVWAGPAQAARRGPWEQFARDRSRFARRIAQAEEQLGPYLTPAFRARAWTRLRNLPLPLSSSSLPLPEPCSSTEATPLSQDVTTPSPLPSEIPPPSLDLGGRRG
What is the function of this protein?
Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress.  Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1.  May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.  Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 15A, Growth arrest and DNA damage-inducible protein GADD34, Myeloid differentiation primary response protein MyD116 homolog, Progression elevated gene 3 protein, PEG-3.
What is the protein family that this protein belongs to?
Belongs to the PPP1R15 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membranes via an N-terminal amphipathic intramembrane region.
Protein: VM2_BITAR
Sequence: SPPVCGNKILEQGEDCDCGSPANCQDRCCNAATCKLTPGSQCNYGECCDQCRFKKAGTVCRIARGDWNDDYCTGKSSDCPWNH
What is the function of this protein?
Inhibits fibrinogen interaction with platelets.  Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.
What are the official names of this protein?
Disintegrin bitistatin, Arietin, Bitan-alpha, Bitistatin D1, Platelet aggregation activation inhibitor, Venom protein CM-2.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TLR2_PANTR
Sequence: MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFRFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLIVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNVDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
What is the function of this protein?
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components.  Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  May also promote apoptosis in response to lipoproteins.  Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.  Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
What are the official names of this protein?
Toll-like receptor 2.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.
Protein: MARH2_MOUSE
Sequence: MTTGDCCHLPGSLCDCSSSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDSQSDCPFCRICHEGANGENLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFVFITPLAAISGWLCLRGAQDHLRLHSRLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADGSEDPHHSLLATGLLKKVAEETPV
What is the function of this protein?
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.  Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity).  Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity).  Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity).  Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteosomal degradation (PubMed:32935379).  May be involved in endosomal trafficking through interaction with STX6.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF2, Membrane-associated RING finger protein 2, Membrane-associated RING-CH protein II, MARCH-II, RING finger protein 172, RING-type E3 ubiquitin transferase MARCHF2.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasm. Cell membrane; Multi-pass membrane protein.
Protein: YCFP_SALG2
Sequence: MIIYLHGFDSNSPGNHEKVLQLQFIDPDVRLVSYSTRHPKHDMQHLLKEVDKMLQLNVDERPLICGVGLGGYWAERIGFLCDIRQVVFNPNLFPYENMEGKIDRPEEYADIDTKCVTNFREKNRDRCLVILSRHDEALDSQRSAQALHPYYEIVWDEEQTHKFKNISPHLQRIKAFKTLG
What are the official names of this protein?
UPF0227 protein YcfP.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: CYSD_MYCBO
Sequence: MTSDVTVGPAPGQYQLSHLRLLEAEAIHVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNFDEVIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAEQVRLPSIYFAHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFRTVGDVTCTGCVESSASTVAEVIAETAVARLTERGATRADDRISEAGMEDRKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: ARGB_SHESR
Sequence: MSTNNSVLVLKVGGALLQCEMGMARLMDTAAAMIANGQQVLMVHGGGCLVDEQLAANGMETVKLEGLRVTPPEQMPIIAGALAGTSNKILQGAATKAGIVSVGMSLADGNTVSAKIKDERLGLVGEVSPKDATYLKFILSQGWMPICSSIAMMDDGQMLNVNADQAATVLAKLVGGKLVLLSDVSGVLDGKGQLIPSLTGQQIAELVKQGVIEKGMKVKVEAALEVAQWMGQAVQVASWRDASQLVALAKGEAVGTQIQP
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUD_CAMJE
Sequence: MNLEEENTIFKPLYSLKHSPINAYFSKNSDDFVVRERPLYEFSGKGEHLILHINKKDLTTNEALKILSEASGVKIRDFGYAGLKDKQGSTFQYLSMPKKFESFLSNFSHPKLKILEIFTHENKLRIGHLKGNSFFIRLKKVLPSDALKLEQALMNLDKQGFANYFGYQRFGKFGDNYKEGLEILRGKKMKNVKMKEFLISAFQSELFNRYLSKRVELSHFANDFSEKELIQIYKISKEEAKELKKQEQFFKLLKGEVLGHYPFGKCFLCEDLSAELGRFKARDISAMGLLIGAKAYETGEGLALNLENEIFKDTLEFKAKMQGSRRFMWGYLEELKWRYDEEKAHFCIEFFLQKGSYATVVLEEILHKNLFE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: RL20_SINMW
Sequence: MARVKRGVTSHAKHKKTLKAAKGFYGRRKNTIRAAKAAVDRSKQFAYRDRKVNKRNFRALWIQRINAAVREFGLTYGRFIDGLNKAGIEVDRKVLSDMAIHEPAAFGALVEASKKALAYLKDAGTANEFESAVR
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NADM2_SULAC
Sequence: MHRGLYPGRFQPFHIGHLEVVKWSMKHVDELIIVIGSAQESHTLSNPFTAGERIEMIRRTLDKENLDLSKVYIIPIPDIMMNSVWVSHIKTFAPNFDVIISRNPLVNRLFKEANVEVLQPPPFDRHKYNSTLIRRYIIEGNEEWKKLVPKSVLDYLLEIHGDERLRSIAGL
What are the official names of this protein?
Nicotinamide-nucleotide adenylyltransferase 2, NAD(+) diphosphorylase 2, NAD(+) pyrophosphorylase 2, NMN adenylyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the archaeal NMN adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRGA_BACSU
Sequence: MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFFTLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG
What is the function of this protein?
Forms highly stable, multimeric protein-DNA complexes which accumulate in stationary-phase cells and protect against oxidative killing.
What are the official names of this protein?
Metalloregulation DNA-binding stress protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
Protein: SYL_AGRFC
Sequence: MAIERYNPRDAEPRWQQKWNEDKVFVTDNSDPREKYYVLEMFPYPSGRIHMGHVRNYAMGDVVARYKRARGFNVLHPMGWDAFGMPAENAAMQNKVHPKDWTYQNIATMRGQLKSMGLSLDWTREFATCDVEYYHRQQALFVDFMEKGLVYRKQSKVNWDPVDHTVLANEQVIDGRGWRSGALVEQRELTQWFFRITDFSQDLLDELDELDQWPEKVRLMQKNWIGRSEGLSLRWQTVADTAPQGFSDITVYTTRPDTLFGASFLAIAADHPLAKELSATNPAIAEFCDECRRHGTSLAALETAEKKGIDTGVKVVHPLDPSWELPVYVANFVLMDYGTGAIFGCPSGDQRDLDFARKYGLPVVAVVAPEGPDAASFTVEDTAFTDDGVMINSSFLNGMKTTDAFEAVVQKLSAQSLGNAPQAERKVNFRLRDWGISRQRYWGCPIPVIHCEVCGVVPVPKKDLPVKLPDDVTFDVPGNPLDRHSTWRHVSCPQCGHDARRETDTMDTFVDSSWYYTRFTAPWEDEPTDPQVANHWLPVDQYIGGIEHAILHLLYSRFFTRAMRETGHVGVKEPFKGLFTQGMVVHETYSRGEGLTREWVPPAELRIEENDGTRRAFLLSSGEEVKIGSIEKMSKSKKNVVDPDDIIASYGADTARFFVLSDSPPDRDVIWSEAGVEGANRFVQRVWRIIGEAAEQLKGVKPKPATEGEGLAASKAAHKTLKAVQEDLDKLAFNKAIARIYELVNALAGPLADVAAGGKPDNVKAAARDAVEILIRIIAPMTPHLAEECWSALGNEGLVAETPWPTFVASLVEENDVVMPVQVNGKKRGELTIARDADQDAVRTAALELDAVKSILAGGEPKKVIVVPQRIVNIVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRPH_SYNE7
Sequence: MSLSPRSDRTEIRRSWGLDSIVSALSQASTDPLPHHLLSDQFYPLPSRESLGLILHGLRSVLFPRHFGDPELSVETTHYFIGNTLDKTLNLLNEQIRRELWLQHVTQGTPEATPAVLSQHASELTQAFAQALPEIKRLLDSDVNAAYLGDPAAQSISEILFCYPGITAITFHRLAHRLYQLGLPLLARITAEVSHSETGIDIHPGAAIGGSFFIDHGTGVVIGETCVIGDRVRIYQAVTLGAKSFPRDETGALIKGQARHPVIEDDVVIYAGATLLGRITVGRGSTIGGNVWLTRSVPAGSFISQAQIRSDNFESGGGI
What are the official names of this protein?
Serine acetyltransferase, plasmid, SAT.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSA2_BURPS
Sequence: MNVAISPGVTAGNSLPFVLFGGINVLESLDFTLDVCGEYVAVTRKLGIPFVFKASFDKANRSSIHSYRGVGLDEGLKIFAEVKARFGVPVITDVHEVEQAAPVAEIADVLQVPAFLARQTDLVVAIAKAGKPVNVKKPQFMSPTQLKHVVSKCGEVGNDRVMLCERGSSFGYDNLVVDMLGFRQMAETTGGCPVIFDVTHSLQCRDPLGDASGGRRRQVLDLARAGIAVGIAGLFLEAHPDPDRARCDGPSALPLHQLEGFLSQMKAIDDLVKRMPALEIR
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase 2, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase 2, KDO-8-phosphate synthase 2, KDO 8-P synthase 2, KDOPS 2, Phospho-2-dehydro-3-deoxyoctonate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.