PharMolix/UniProtQA huggingface dataset:
Protein: ERCC3_CHICK
Sequence: MGRKERDKKKSKKRHYEDEEEEEDDAPGKESQEAVPSAAGKQVEDSGAKLDEYGAKDYRLQMPLKADNASRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHIHEYKLTAYSLYAAVSVGLQTSDITEYLQKLSKTGVPEGIIQFIKLCTVSYGKVKLVLKRNRYFVESTHPDVIQQLLQDHVIKDCRLRNAEGEETELITETFTSKSAISKSSESGFGPSTSQEADVQNKPDVPADLYEFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLDYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIDCSIAISTYSMLGHTTKRSWEAERVMEWLKSREWGLMILDEVHTIPAKMFRRVLTIVQAHCKLELTATLVREDDKIVDLNFLIGPKLYEANWMELQNSGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLGKPYIYGPTAQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEELSFSSKEEQQQLLQKVLQASDLDAEEEVVAGEYGSKSVQMSRRTGTMSSMSGADDAVYMEYHSSRSKASSNKHIHPLLSASGNDVLHVCVL
What is the function of this protein?
ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH helicase subunit XPB, TFIIH subunit XPB, DNA excision repair protein ERCC-3.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RAD25/XPB subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: THIC_MOUSE
Sequence: MNAGSDPVVIVSAARTAIGSFNGALSTVPVHEMGTTVIKEVLQRAKVAPEEVSEVIFGHVLTAGCGQNPTRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAAQSIAMGDSTIVVAGGMENMSKAPHLTHLRTGVRMGEVPLADSILCDGLTDAFHNYHMGITAENVAKKWQVSREAQDKVAVLSQNRAEHAQKAGHFDKEIVPVLVSSRKGLTEVKIDEFPRHGSNLEAMGKLKPYFLTDGTGTVTPANASGMNDGAAAVVLMKKTEAERRMLKPLARIVSWSQAGVEPSVMGVGPIPAIKQAVAKAGWSLEDVDLFEINEAFAAVSAAIAKELGLNPEKVNIDGGAIALGHPLGASGCRILVTLLHTLERVGGTRGVAALCIGGGMGVAMCVQRG
What is the function of this protein?
Involved in the biosynthetic pathway of cholesterol.
What are the official names of this protein?
Acetyl-CoA acetyltransferase, cytosolic, Cytosolic acetoacetyl-CoA thiolase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: BAR1_SCHCO
Sequence: MLDPLYPLFPIFAFLGFVLAILPLPWHLQAWNSGTCFFMMWTALGCLNQFINSVAWADDAMNKAPVWCEISIRILMGASVGIPASSLCIIRRLYYIAKVRAVSKTRAEKMRAILVDALICVLFPLVYIALQYIVQGHRFNILENIGCYPAVTNTPVTYVVSYVWPVLLGLISATYGVMALLQFNKHRLQFSQFLHTHSTLSASRYLRLMALALTEMMCTMPLGIFVIVLNSKTENIQPWVSLAVTHYGFGRIDQVPAIVWRSQHLIVVCNELTRWCAPVSAFIFFFYFGFAEEARRNYAAAWRRVCRALGLPERVPSLPTTKKPFSSSDNKGSGFAEKFAAKAKGFSNFNVKDFTSEFTSKAHDFTSKAKQYTLPRPMPQTLSSSGFSSSDSTRFGSSVDGKELPSPTTKEFSSPIPIHLSGMQTLASFDSNKDLPSPPAYDIEAQYGPYNIDNRVSYHIADTGVRASYPMGVAYSSDSEHRRIVPHHSTVPHHSTADEPASPALPDTPSSCSSSATFSTLQSRDFIVLPSSADVTRRDSGSSAGGVASTSRPTRAGPPRLPSLSQLFGISSMRGQEGDVEAQGEEMAADVDVSEMVLDTLAPASIIAATTTAGAPATTTPDRGEPDVPTSPRTHRASV
What is the function of this protein?
Receptor for the BAP1 pheromone, a prenylated mating factor.  Has a role in the initiation of B-regulated nuclear migration.
What are the official names of this protein?
Pheromone B alpha 1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 4 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KCY_PHYMT
Sequence: MKGFKIAIDGPAASGKSTICKLIAEKLNCVHIDTGLMFRVITLYLIKNKVNWAQITEENYLKLLLNNCNIYYEKNHIYCNYQKMCLEIKLKRIEIDNKVSLVASLPFIRQKLLLLQQEIIKNNPYLIMDGRDIGTIVMPNADLKIFLTANIEQRILRRVNEFKSNKSVNELQKITNNIKLRDHKDFNRLISPLKKAEDAILLDTTDINIIETVNQIHNLILHKKKLLNQNEF
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_PSEPU
Sequence: MDIKSALSRIVGQLDLTTEEMRDVMRQIMTGQCTEAQIGAFLMGMRMKSESIDEIVGAVSVMRELADKVELKSLDGVVDIVGTGGDGANIFNVSTASSFVLAAAGCTVAKHGNRAVSGKSGSADLLEAAGIYLNLTPTQVARCIDSLGIGFMFAQSHHSAMKHAAGPRRDLGLRTLFNMLGPLTNPAGVKHQVVGVFAQTLCRPLAEVLQRLGSKHVLVVHSKDGLDEFSLAAPTFVAELKNGEITEYWVEPEDLGMKSQSLHGLAVENPQASLELIRDALGRRKTENGQKAAEMIVLNAGAALYAADHAMTLAQGVELAHDVLHTGLAWEKLQELGAFTAVFKVENEA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RPOE_BACLD
Sequence: MSLKQYSEEQLKEMALVEIAYEIFSEHKKPITFQELTDQVASLLGMGKEELEDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKAKKAVEEDLDLDEFEEIDEDDILLDDVEEDLDIDADEFDEIDEADDDELDDLEDEILDDDEDFDEEEDEE
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: RECO_ANAPZ
Sequence: MQWQDHGMIVSMTPYGDTRSILSVFTRNHGICNAMIRLNKKKQSLQIGDRVCVTWRARLANNLGYFNSCEIISSAFYAYFQDHSKLLCLSSVTSTIYKSVPTNDAHPILYDYLIEFAEAAECGGHWYNEYLKLELEILSQLGFALDLSRCAVYHCEDNLLYISPKTGRAISERAGVSYRHLLFPLPQILRDLHNGTHTEQCSRKEFLLCLQILGYFLHRHLLSDDSKFLEQRKEMTALIYEEEAF
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RR7_LACSA
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRAVKKIQQKTETNPLSVLRQAIHGVTPGIAVKARRVGGSTQQVPIEIGSTQGKALAIRWLLAASRKRPGRNMAFKLSSELVDAAKGSGDAIRKREETHKMAESNRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OBG_PERMH
Sequence: MRFIDKAKIHVKAGDGGNGCVAFRREKYVRMGGPSGGNGGKGGDVIIMADKSLKTLMDFRYKKHFKAENGQHGSGNNRHGRNGKDLIIKVPVGTVVKDAETGEILADLIYDGQKVVVAKGGRGGRGNAAFKTSTNQAPDYAEEGQPGEERWIELELKLIADIGIIGFPNAGKSTLISVLSKAKPKIADYPFTTLTPVLGVLQLDYGKSVVIADIPGLIEGASKGAGLGHEFLRHIERTKALIHMIDISDQRERDPIEAFEIINKELEKYSPELVKKPQIVVGNKIDMLSDRSLIEKLKKEFSKRGYPFVAVSLVTKEGLDQLIKLIAEVYEKISEKELIK
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNCB_XANCP
Sequence: MIIHSLLDTDLYKFTMMQAVLHQHPAAQVDYRFKCRTPGVDLAQFIDEISREIDALCRLRLREDEVDYLRSLRFIKPDFADFLALFHLDRKYLALAASAAHPGEIELTIRGPWLHTILFEVPLLAIINEVWFRNTSEPDFEEGRSRLREKVRSLRSMPAGCKIADYGTRRRYSRQWHGELLPLLRDGLGEQFVGTSNVFFAKQYGLTPLGTMAHEYLQAFQALGPRLRDSQVAALDSWAREYRGDLGIALSDVVGLDAFLRDFDLYFCKLFDGMRHDSGDPFDWGERVIAHLEAHRVDPRTKVLVFSDGLNIDKVMRLYEHFSPRCRLAFGVGTSLTNDLGPTPLQIVIKMVRCNGQPVAKLSDSPGKSMCEDLGYLRYLRDVFGLPPMPEAGDPARQ
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: MRGX3_MACMU
Sequence: MDPTIPALGTSQTPINRREETPCYKQTLSLTVLTCIISLVGLTGNAVVLWLLGFRMRRNAVSTYILNLAAVDFLFLSGHIVRSPLRLISIRHPISKIVNPVMTFPYFIGLSMLSAISTERCLSVLWPMWYRCRRPRHLSVVVCVLLWALSLLRSILEWMFCDFLFSGADSVWCETSDFITIAWLIFLCVVLCGSSLVLLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGIQWALFSRIHLDWKVLFCHVHLISVFLSSLNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDTPEVDEGGGRLPEETLELSVSRLEQ
What is the function of this protein?
Orphan receptor.  Probably involved in the function of nociceptive neurons.  May regulate nociceptor function and/or development, including the sensation or modulation of pain.  Potently activated by enkephalins (By similarity).
What are the official names of this protein?
Mas-related G-protein coupled receptor member X3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SURF1_MOUSE
Sequence: MAAVMALAVLPRRMTRWSQWAYAGRAQFCAVRRSVFGFSVRSGMVCRPRRCCSSTAETAAAKAEDDSFLQWFLLLIPATAFGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPADPMELKNLEYRPVKVRGHFDHSKELYIMPRTMVDPVREARDAGRLSSTESGAHVVTPFHCSDLGVTILVNRGFVPRKKVNPETRQKGQVLGEVDLVGIVRLTENRKPFVPENSPERNHWYYRDLEAMAKITGADPIFIDADFHSTAPGGPIGGQTRVTLRNEHMQYILTWYGLCAATSYLWFQKFVRRTPIM
What is the function of this protein?
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex (By similarity).  Regulates cytochrome c oxidase assembly (PubMed:17210671, PubMed:23838831, PubMed:24911525).
What are the official names of this protein?
Surfeit locus protein 1.
What is the protein family that this protein belongs to?
Belongs to the SURF1 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: ACCD_LACP3
Sequence: MSQPQLTQEALAREAALPENLWIQCPYCKQGSYRESLGNAQVCPHCHYGFRITAKKRLSLIATATEEWDADLVTSDPLDFPGYTEKLAAGQAATGLKDSVWTGQATIGGQSCALGIMDPKFMMGSLGTVTGERLTRLFEKATSANLAVVLFCASGGARMQEGIHSLMQMAKVSAAVKAHSNAGLLFISVLTDPTMGGVTASFAMQGDITLAEPHSLIGFAGRRVIEQTINQKLPQNFQRAETLLQSGFIDAVVQRQDQPSYLGDLLALHTA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_SPHVA
Sequence: MAPNLRKSHPILKMINNSLIDLPAPSNISAWWNFGSLLGICLLTQIITGLLLATHYTADTTLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLFKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAFPYIGQTIVEWAWGGFSVDNPTLTRFFALHFLLPFMIAGLTLIHFTFLHESGSNNPLGIVSDCDKIPFHPYFSVKDILGFMLMLLPLTALALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLAPLLHVSKQRTMAFRPLSQLLFWTLVANLLILTWVGSQPVEHPFIIIGQLASITYFLTILFLFPLTSALENKLLNF
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CARB_CALS4
Sequence: MPKYKDISKVLVIGSGPIIIGQAAEFDYSGTQACKSLKEEGVQVVLVNNNPATIMTDTDIADIVYIENPTVEVVEKIIAKERPDGILATLGGQTGLNLAVKLKEAGILDKYNVKLLGTSVESIKTAEDRELFKRKMQEIGEPVAESVTVTNVEDALKFAKNYGYPLIIRPAYTLGGTGGGIAHNDEELISIVDLGLKKSMVGEVLVEKSLYGWKEIEFEVMRDAADNCITICSMENFDPVGVHTGDSIVVAPAQTLSDYEYQMLRSASIKIIRALKIEGGCNIQFALDPQSHKYYVIEVNPRVSRSSALASKATGYPIAKIAAKIAIGLRLDEIKNPVTGKTTAFFEPALDYVVTKIPRWPFDKFYTTDRRIGTQMKATGEVMAIERSFEASLLKAVRSLEIKAYGLRLDSVRGMGTKEILEDISVPNDMRLFYIAEALRRNIDIDYINDVTKIDKWFLNKLSNIVNMEKEIEENELSKEILKKAKRMGFSDREIATIKGIKEEDVRTLRKKYGIYPSYKMVDTCAAEFESITQYIYSTYCEEDEVETHDIPKVIVIGSGPIRIGQGIEFDYCSVKALWALKETGIKSIIINNNPETVSTDFDTGDRLYFEPITLEDVLNIYEKEKPLGVMVMFGGQTAINLTEELVKNEVKILGTSFKSIDISEDREKFSKLLKELNINQPKGGYALTVEDAKDIALKLGFPLLVRPSYVIGGQSMEKVNTLQELIDYVKHATEVSPGKPVLIDKYIDGREVEVDAVSDGECVLIPGIMEHIERTGVHSGDSFSIYPARNLTEREINTIIEYTEKISKALNVKGLINIQFAVKEGTVYVLEVNPRASRTVPIMSKATGVPMVKLAVEVALGKKLKELGYKGGLWPQTPYTVVKAPVFSMEKLTDVEVSLSPEMKSTGEIMGIDLSYEGALYKALEGAGLKIPKKGKILLSIAERDFQEAVSLVEKLQSLGYEIYATYRTGKYFSLMGIHANIMSLDHAIKLLKNGYFDAVVNTPTKGKKPDNAGFKLRRTAVEYRIPLFTSIDTIKAALNAVSKVNVNGLSVLSMNEYQEIQKDNVKNLVL
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: ARGJ_NEIMB
Sequence: MAVNLTEKTAEQLPDIDGIALYTAQAGVKKPGHTDLTLIAVAAGSTVGAVFTTNRFCAAPVHIAKSHLFDEDGVRALVINTGNANAGTGAQGRIDALAVCAAAARQIGCKPNQVLPFSTGVILEPLPADKIIAALPKMQPAFWNEAARAIMTTDTVPKAASREGKVGDKHTVRATGIAKGSGMIHPNMATMLGFIATDAKVSQPVLQLMTQEIADETFNTITVDGDTSTNDSFVIIATGKNSQSEIDNIADPRYAQLKELLCSLALELAQAIVRDGEGATKFITVRVENAKTRDEARQAAYAVARSPLVKTAFFASDPNLGRLLAAIGYAGVADLDTDLVEMYLDDILVAEHGGRAASYTEAQGQAVMSKAEITVRIKLHRGQAAATVYTCDLSHGYVSINADYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_METPB
Sequence: MSDTNNPGDKTQTRAPSKPLTLKRPVEQGTVRQSFSHGRSKSVVVETVKRRTIGAAPGTVAPREPVAAPPPRPASVAPAPAAPARPAGRSASGVVLRTLSEQERDARAAALADAQRREAEARARAEAEVKARRDREEAERREREAAEARRREEEERRRQEDELRRKAAEDSRRRAEEEAARAAAAAPVDEAPAEAPAAPAPVAEAAPTVAPTPAPAPRPAPAPARPAAAAPAARPGAAPQRPAASGARPGVAGARPAPTAARPAAPQAPAEPRRTITADVKKPRDLNFMARPAPAPEPEKAPSPTTAARPAGTAARPAARPGAAAAEDESDTKRVIRRPGMPLKIITPPKTPKSPGGDRNRGRLTIANATAGEDERTRSVASFRRRQQRMSGHRHEEPKEKIARDVTIPETITIQELANRMSERAVDVIRLLMKQGQIHKITDVIDSDTAQLIAEEMGHTVRRVAESDVEEGLTSDEPDLEEDLEPRPPVVTIMGHVDHGKTSLLDAIRRANVVEGEAGGITQHIGAYQVAAPSGDLITFIDTPGHAAFTSMRARGAKVTDIVVIVVAADDGVMPQTIEAIQHAKAAGVPMIIAINKIDKADANPQRVRTELLQHDIQVESMGGETLEFEVSAKTGDGLPELLEGLQLQAEIMNLRANEKRDGEGTVIEAQLDRGRGPVATVLVQRGTLFTGDIIVAGAEWGRIRALIDDTGKHIPYAGPSVPVEVLGFNGTPDAGDRVIVVPNEARAREVTEYRARIKRERLNARTGGANRSLVDMMREAKEGANRKELPIIIKGDVQGSVEAINGALTALGNDEVGVRILLSGVGGITESDITLANASKAVVIGFNVRAHKEARNAAERDGTEIRYYSIIYDLVDDIKATLSGMLPPTLREERLGEAQILQIFDVSKVGKIAGCRVMEGVVQRGAHVRLLRNDVVIHEGKLAQLKRLKDDAKEVTAGYECGMSFQNYQDMRVGDFIECFNVEEIKRTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTP_ECO24
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMMGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSITVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VATB_STRPN
Sequence: MSVIKEYRTASEVVGPLMIVEQVNNVSYNELVEIQLHNGEIRRGQVLEIHEDKAMVQLFEGSSGINLEKSKIRFAGHALELAVSEDMVGRIFNGMGKPIDGGPDLIPEKYLDIDGQAINPVSRDYPDEFIQTGISSIDHLNTLVRGQKLPVFSGSGLPHNELAAQIARQATVLNSDENFAVVFAAMGITFEEAEFFMEELRKTGAIDRSVLFMNLANDPAIERIATPRIALTAAEYLAFEKDMHVLVIMTDMTNYCEALREVSAARREVPGRRGYPGYLYTNLSTLYERAGRLVGKKGSVTQIPILTMPEDDITHPIPDLTGYITEGQIILSHELYNQGYRPPINVLPSLSRLKDKGSGEGKTRGDHAPTMNQLFAAYAQGKKVEELAVVLGESALSDVDKLYVRFTKRFEEEYINQGFYKNRNIEDTLNLGWELLSILPRTELKRIKDDLLDKYLPLVEV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: MUTS_COXBN
Sequence: MELQTKSPTTQNDFSQHTPMMRQYLRIKAEYPDLLVFYRMGDFYELFYDDAKKAAKLLNITLTARGQSAGHAIPMAGVPYHAVENYLTKLVRLGESVVICEQIGDPATSKGPVAREVTRIITPGTVSDEALLDEHRDNTLMVIHQEKDRFGIATLDITSGRFLIQEIISENALFAEIERIRPAELLISEENSVHPLKADSIKRRPPWEFDHATALTLLCQQFQTKSLDGFGITHLPLAITAAGCLLQYVNYTQKSALPHIHSIQAEQNEEALFIDANTRRNLELITNLQGEEVHSLAWLLDHTATPMGSRLLRRWINRPLRDQILLQQRQNAVSTLLEKRNYSEIYENLRHIGDLERIVARIALRSARPRDLMQLRQALGVLPTLHQQLTNLPLNKQLQEIKNNLGLFDELFRLLQKAIIENPPIVIRDGGVIADGYDAPLDELRNMSTNSHQFLIDLEQQERERTKINTLKVGYNRIHGYYIEISRAQAKQAPTEYIRRQTLKNVERYITPELKIFEDKVLSSRSRALAREKELYEQLLDTLIEKLIPLQQCASAIANLDVLNTLAERADTLNFNAPQFCDYPIIKIEAGRHPIVENVMTDPFMPNDTHLDEKRRMLIITGPNMGGKSTYMRQTALITLLAYIGSFVPAKNAQLGPIDRIFTRIGAADDLASGRSTFMVEMTETAAILHNATEESLVLMDEVGRGTSTFDGLSLAYACASYLATKLKAFALFATHYFELTALASTLPAVKNVHLDAVEHEEKIIFLHALREGPANKSYGLQVAQLAGIPRSVIQHARQKLEELENPVISETQQPQQNELFLPIENPVLTQLDKLNPDNLTPKQALDILYQLIQLRQQK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: YAEH_ECO81
Sequence: MYDNLKSLGITNPEEIDRYSLRQEANNDILKIYFQKDKGEFFAKSVKFKYPRQRKTVVADGVGQGYKEVQEISPNLRYIIDELDQICQRDRSEVDLKRKILDDLRHLESVVTNKISEIEADLEKLTRK
What are the official names of this protein?
UPF0325 protein YaeH.
What is the protein family that this protein belongs to?
Belongs to the UPF0325 family.
Protein: CAPG_MOUSE
Sequence: MYTPIPQSGSPFPASVQDPGLHIWRVEKLKPVPIARESHGIFFSGDSYLVLHNGPEEASHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYYREGGVESAFHKTTSGARGAAIRKLYQVKGKKNIRATERPLSWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIITDGEEPAEMIQVLGPKPALKEGNPEEDITADQTRPNAQAAALYKVSDATGQMNLTKVADSSPFASELLIPDDCFVLDNGLCAQIYIWKGRKANEKERQAALQVADGFISRMRYSPNTQVEILPQGRESPIFKQFFKNWK
What is the function of this protein?
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments.  May play an important role in macrophage function.  May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin.  May bind DNA.  Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+).
What are the official names of this protein?
Macrophage-capping protein, Actin regulatory protein CAP-G, Actin-capping protein GCAP39, Myc basic motif homolog 1.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia.
Protein: UCRI_MOUSE
Sequence: MLSVAARSGPFAPVLSATSRGVAGALRPLLQGAVPAASEPPVLDVKRPFLCRESLSGQAAARPLVATVGLNVPASVRFSHTDVKVPDFSDYRRAEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYAAKNVVSQFVSSMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPAYEFTSDDVVVVG
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).  UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer.  One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS).  The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function.
What are the official names of this protein?
Cytochrome b-c1 complex subunit Rieske, mitochondrial, Complex III subunit 5, Cytochrome b-c1 complex subunit 5, Rieske iron-sulfur protein, RISP, Rieske protein UQCRFS1, Ubiquinol-cytochrome c reductase iron-sulfur subunit.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.