PharMolix/UniProtQA huggingface dataset:
Protein: U2A2B_ORYSJ
Sequence: MADDHAAAADLVDGGRPEGDTHSREDGLSKPRDKDREREKDKDRERHRDRDRDRGRDRDRDKDKEKDRDKERDRDRDRDKDRDRHHRHHRERREHRDRSDDHDRHRSRDSERRRDHERDGRRRHRSRSRSRSRGRDRRSRSRSRSKSKRVSGFDMAPPAQAVVPQFPAIPTPSQFPGTAIPGMFPNMLPMGVGQFNPLVIQPQAMTQQATRHARRVYVGGLPPTANEQSVAIYFNQVMAAIGGNTAGPGDAVLNVYINHDKKFAFVEMRSVEEASNAMALDGILFEGAPVKVRRPTDYNPSLAAALGPSQPSPNLNLAAVGLTPGSAGGLEGPDRIFVGGLPYYFTEAQVRELLESFGPLRGFDLVKDRETGNSKGYAFCVYQDLNVTDIACAALNGIKMGDKTLTVRRANQGAAQPRPEQESILLQAQQQVQLQKLVYQVGALPTKVVCLTQVVSADELKDDEEYEDIMEDMRLEAGKYGNLIKVVIPRPDPSGLPVAGVGKVFLEYADVDGATKAKTAMHGRKFGGNPVVAVFYPENKFSSAEYDA
What is the function of this protein?
Necessary for the splicing of pre-mRNA.
What are the official names of this protein?
Splicing factor U2af large subunit B, U2 auxiliary factor 65 kDa subunit B, U2 small nuclear ribonucleoprotein auxiliary factor large subunit B, U2 snRNP auxiliary factor large subunit B.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RDRP_I18A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: VG90_GAHVM
Sequence: MSRVNATMFDDMDIPRGRFGKPPRKITNVNFWHVVVDEFTEGIVQCMEARERLGLLCTISTNEGSITSFDIHKDMWCQMVIWSAYRFFAMMDKMFSIETITNFTETDLTETGQWRIFYRTWDVRDALKMKQVGPFLPALFSFHLENWTTMLSIGINKGYDRHNTRNMFMTIQSARNVLSGAMEVARYAVVLALPVCEYRTPLGLPDDSIGNAIKTCCTQMQANRLTETGISKDSGHKINDSSEEELYYRTIHDLIKPNREHCISCNIENSMDIDPTIHHRSSNVITLQGTSTYPFGRRPMSRMDVGGLMYQHPYICRNLHLRPPRSRLMNSKILQTFRQSFNRSNPHAYPI
What are the official names of this protein?
Uncharacterized gene 90 protein.
Protein: SUFE_SHIF8
Sequence: MALLPDKEKLLRNFLRCANWEEKYLYIIELGQRLPELRAEDGSPQNSIQGCQSQVWIVMRQNAQGIIELQGDSDAAIVKGLIAVVFILYDQMTPQDIVNFDVRPWFEKMALTQHLTPSRSQGLEAMIRAIRAKAAALS
What is the function of this protein?
Participates in cysteine desulfuration mediated by SufS.  Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.
What are the official names of this protein?
Cysteine desulfuration protein SufE.
What is the protein family that this protein belongs to?
Belongs to the SufE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_STAAS
Sequence: MHFIAISINHRTADVALREQVAFRDDALRIAHEDLYETKSILENVILSTCNRTEVYAVVDQIHTGRYYIQRFLARAFGFEVDDIKAMSEVKVGDEAVEHLLRVTSGLDSIVLGETQILGQIRDAFFLAQSTGTTGTIFNHLFKQAITFAKRAHNETDIADNAVSVSYAAVELAKKVFGKLKSKQAIIIGAGEMSELSLLNLLGSGITDITVVNRTIENAMKLAAKHQVKYDELSSLPNLLESADIVISSTSAQSYIITNEMIERIAENRKQDSLVLIDIAVPRDIEPGISAITNIFNYDVDDLKGLVDANLRERQLAAATISEQIPAEIHAHNEWISMLGVVPVIRALREKAMAIQAETMDSIDRKLPGLSERERKIISKHTKSIINQMLKDPIKQAKELSSDKKSNEKLELFQNIFDIEAECPHEQAKQQKESKVKEISARRIFSFE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: KCY_ECO57
Sequence: MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDALVPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFRELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLALA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_COXBN
Sequence: MVSRVAKNPIKIPTGVEVNVAGQQITVKGKLGTLTRVIHRAVKVTKTDAELQTICANDSPGSNALAGTARAVLANMVQGVHTGFQRKLVMVGVGYRAKAEGKKLNLTVGLSHPVNIEMPEGITVETPSQTEIIVKGADKQRVSQVAANIREIRPPEPYKGKGIRYDNERVILKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: FOLD_RICFE
Sequence: MNNIIDGKALANEILADLKLEIQELKSQTNTSPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTDDLISKINELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGISQGFIPCTALGCLAVIKKYEPNLTGKNVVIIGRSNIVGKPLSALLLKEDCSVTICHSKSQNLSSITSKADIVVAAIGSPLKFTTEYFDPESIVIDVGINRISGNKIIGDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKDSYSTVCHSCL
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: TOLB_SHIFL
Sequence: MKQALRVAFGFLILWASVLHAEVRIVIDSGVDSGRPIGVVPFQWAGPGAAPEDIGGIVAADLRNSGKFNPLDRARLPQQPGSAQEVQPAAWSALGIDAVVVGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYAGHTASDEVFEKLTGIKGAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRSPHPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDLAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKFPAWSPYL
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.  TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: UPP_ECO45
Sequence: MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RS12_CLOB6
Sequence: MPTISQLVRKGRKTIASASDSPALKECPQKRGVCTVVKTTTPKKPNSALRKVARIRLTNGYEVTAYIPGVGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDAAGVANRMQSRSKYGAKKPKQK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: AROQ_ANOFW
Sequence: MVRFLLLNGPNLNRLGMREPHIYGHTTLAQLEKQLTEFASEYAVELTCYQSNYEGALIDQIHRAESLYDGIIFNPGAFTHYSYALRDAIASIQTPVIEVHISNIHAREPFRHQSVLAPVTAGQIVGLGVNGYRLAILALLDMVEGKGK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: SCRK2_SOLHA
Sequence: MAVNGASSSGLIVSFGEMLIDFVPTVSGVSLAEAPGFLKAPGGAPANVAIAVTRLGGRSAFVGKLGDDEFGHMLAGILKTNGVQADGINFDKGARTALAFVTLRADGEREFMFYRNPSADMLLTPAELNLDLIRSAKVFHYGSISLIVEPCRAAHMKAMEVAKEAGALLSYDPNLRLPLWPSAEEAKKQIKSIWDSADVIKVSDVELEFLTGSNKIDDESAMSLWHPNLKLLLVTLGEKGCNYYTKKFHGTVGGFHVKTVDTTGAGDSFVGALLTKIVDDQTILADEARLKEVLRFSCACGAITTTKKGAIPALPTASEALTLLKGGA
What is the function of this protein?
May play an important role in maintaining the flux of carbon towards starch formation.
What are the official names of this protein?
Fructokinase-2.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: RS16_HYPNA
Sequence: MSLKIRLARGGSKKRPFYSIVVADARAPRDGRFIEKIGTYDPRLAKDSGDRVKVNAEKAAEWIKKGAQPTDRVARFLSKVEVDGKAVVAWTHGNNPKKAEPGKKAQERAKERADKAEAKAAAAAEAAAAPAEEAPAEAAPAEETSES
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RBL_TRIV2
Sequence: MSYAQTKTQTKSGYKAGVQDYRLTYYTPDYTPKDTDILAAFRVTPQPGVPFEEAAAAVAAESSTGTWTTVWTDLLTDLDRYKGRCYDIEPVPGEDNQFIAYIAYPLDLFEEGSITNVLTSIVGNVFGFKALRALRLEDIRFPVAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENINSAPFQRWRDRFLFVSDAISKAQAETGEIKGHYLNVTAPTCEEMLKRAEYAKELNQPIIMHDYLTAGFTANTTLARWCRDNGVLLHIHRAMHAVIDRQKNHGIHFRVLAKALRLSGGDHIHTGTVVGKLEGERGITMGFVDLLRENYVEQDKSRGIYFTQDWASLPGVMAVASGGIHVWHMPALVEIFGDDSVLQFGGGTLGHPWGNAPGATANRVALEACVQARNEGRNLAREGNDVIREAAKWSPELAVACELWKEIKFEFEAMDTV
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Carboxysome.
Protein: NUOA_PSEPF
Sequence: MPEATGLMAHNWGFAIFLLGVVGLCAFMLGVSSLLGSKAWGRSKNEPFESGMLPTGGARLRLSAKFYLVAMLFVIFDIEALFLFAWSVSVRESGWTGFVEALVFIAILLAGLVYLFRVGALDWAPEARRKRQAKLKQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYQ_RALPJ
Sequence: MSQDNATAPTSNFLRQIIDADLAQGTYADRKDATGQPIPPVVTRFPPEPNGYLHIGHAKSIWVNFGMARDYNGRCHLRFDDTNPVKEDTEYVDSIIDAVHWLGYSWSDAGGEHLYYASDYFEQLYGFAEVLIQRGVAYVDSQSAEQIAANRGDFTRPGTLSPFRDRSVDENLALFRDMRAGKYKDGEHVLRAKIDMAAPNIVMRDPVLYRIRHAHHHRTGDAWCIYPMYDFTHCISDALENITHSLCTLEFENNRPLYDWVLDHLRDAGVLAAPLPHQYEFARLHLTYAITSKRKLLQLVTEKRVDGWDDPRMPTLVGIRRRGYTPESIQLFCERVGVSKADSWIDMSILEGAVRDDLDARAPRSVAVLDPVKLVLDNVPADFNEPCSAPVHPKQPELGRREFPLTRELWIEREDFTETPPKGYFRLFPGNKVRLRYGYVIECTGCDKDAAGNITAVHANIIPDTKSGTPGADSVKVKGNIHWVSAAHALEAEVRLYDRLFSDPQPDSGDKNFLDALNPNSKKIVKAFLEPTLATAKAEDRFQFERHGYFVADRIDSQPGKPVFNRVVGLKDSWGK
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS212_BURP1
Sequence: MTTIVLNPNEPVEVALRRFRRSIERTGLIKELRARTSYEKPTTERKRKKAAAVARLRKQVRRSMPPKKKY
What are the official names of this protein?
30S ribosomal protein S21 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: TSAD_PROMS
Sequence: MHKVLAIETSCDETSVSIVSNIGDTFRIHSNIIASQIEDHSKWGGVVPELAARKHLELLPFVLDKALEEAKIKIEEVDYIASTVAPGLVGCLRVGSITARSLCMLHSKPFLGIHHLEGHLSSILFSENYPKKSFLTLLVSGGHTELIKVDDSRGMQRLGKSFDDAAGEAFDKVGRLLGLSYPGGPAIEKIAKNGDPMKFNLPKCKISDKKGGFLKYDFSFSGLKTAVLRLVERINLTGKTVPIPDIAASFERVVAEVLVDRTIKCAQDHSLDTVVVVGGVAANNTLRKMMISEASKKSIKVHLAPLDLCTDNAAMIGAAALFRIKFKDHFSSLKLGVAGRLSIEQADNLYEETPPF
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APD1_PIMDI
Sequence: GKPNRPRPAPIQPRPPHPRL
What is the function of this protein?
Among others, also active against Y. enterocolitica butnot against L. pneumophila and C. jejuni.
What are the official names of this protein?
Apidaecin 1+.
What is the protein family that this protein belongs to?
Belongs to the apidaecin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HIS2_METPE
Sequence: MTDTALIAELWDVIVDRRLHPVEGSYVNSLLSHRKGIDKPLEKVGEEATEFILAVKNGESDRIAEEAADLLFHMLVALNAADVDLSLVLDELASRRRSR
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y390_MYCGE
Sequence: MKIIYQEQQNECGICVIGMLANAIHDEKYVHDELLEQINLPPNGLSLFEMESYGKKFGLEINSYQLTFQELKELDSKFIIVHFKDHFVIVKNKHENSWEVYDPAKGKYLLTDEKLEKLWTGYAATVAKAFKEIPPVNKSNFFSNFFDFNLVTFYVFIELIIIGISTLLATASRTIITNTVDFGTAVNLVVLVVYFSCLKGLNLLLQVILQLIRNFLFWKQYRGYLGWIIQSLQQKSFVYFSNKSPNQLIERQFYLKEVLSFFNFYIPNLIISCVVALIIGVLIGINQLEFLLIAIAQIVVNAGLFCYDFFFTKKITKKEIPYVELQNKISLQLDENLREEQNKKRFNFLMLNFRKALLQNQNINNQKEINRLTIENIKSFFQQGFDFAILGLGVIGIIEQRYQLSFLFYVFGIQSLFSTYATRIVQFGAAINIYHYCREKLVNLFIETKKDEGIKVNWQCPDEISLENLSVTLNQHVDLANLSLKIKNETVIFGQNGSGKSTFLKILTGRGFEYTGNIKFNNVDLKRCSKEQLFENVYYLKGQNLMQTEANDFGFSEALFNNQNPHIYQLLFDAGVQNQTKLSSGQKQILQLFLLSNIKNKVILLDECMNAIAPEIKNRVYQLLVKPLTLNNFVVLVEHDLSFASEAQNKINLTNYLRNS
What are the official names of this protein?
Putative ABC transporter ATP-binding MG390.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GOE_DROME
Sequence: MAINQGKYKPSICAIDEVDDRSFKLHNSQDEIGGKQQLQQIEGSETAPLTTNQQKLHMDDGSHLTPKDLEAARQDALNEVAAGGAGGRTPAAITPNSTHPSANGLRALLLPGRRSFDALMSLSRKRRILYVTTACLCALLLLIIILLLAFWPEVPFYLRAPLCLDKECVESSRQLLLWANTSKSPCHETYEWACGNFASDYANHEYFVIKRGEWNYETYNEYQELNELNRFIAMLPNSQEGSVESTVSSLYRSCRETDVLDKSQSDLLLKRAINAVYGWQAFRDSNRLQSWEYKRVLVVLQAKHGIFPYYRVTVENGFSNPHDYVITLDEGELGLPDKYFYGNDADEEVVRGYKLLLRDFAINMGIVSREADLFADDIFHYERRIVNHIEDAKADANRPINKLMRLADLKIKAPSLPILESLQAIFPKTKITEDTEVLVRDPEVMHALSVLLSTSDKKPINNFIVWSLARKMLPHLSKEYRTLAETFDHALYGRTASYPRWLICSKVVRDWLPFAVDALQQQPPRQQFETMTSKSRGLNKTQGNEELLKLMFFSLRNQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFGIPDEVLQQPTYLAQYYNELILNNVFFVEHLEWIWTFRRSQMEKKLGPLAILDVIVSEMYTRDNPQAIAYSNKLNMLLVSKVLISSNYYDYRYPVAVNFARIGTDILEALIDNFSTFLLQFNTQSTDISDAAPEIRYAQPDVNCLAAGQPPRLVHELNELSSNALKSFHVTLSAARTAARALSNFVNAIDAGSAIQGSGIDQANTYEALGLTRRLRIPGLRSFNENELFTLSYMQQHCSTTIADKDYARIKPLVESQLAESYLFNATWQHIQFLPRSTNCAAAEATCSNLL
What is the function of this protein?
Plays a role in the ovary in limiting the number of primordial germ cells (PGCs) that develop directly into gametes, allowing them instead to enter the developmental pathway that produces germline stem cells (GSCs) from PGCs and ensuring lifelong production of gametes from these GSCs.  Negatively regulates epidermal growth factor receptor (Egfr) signaling.  Probably down-regulates EGFR signaling on intermingled cells, a type of somatic stromal cell which contacts PGCs, and the resultant low level of signaling limits the proportion of PGCs which start gametogenesis, maintaining them in an undifferentiated proliferative state.
What are the official names of this protein?
Protein gone early.
What is the protein family that this protein belongs to?
Belongs to the peptidase M13 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Not uniformly present at the cell membrane but is concentrated at the interface between germ cells.
Protein: RL14_CHLCH
Sequence: MIQKETNLVVADNSGAKKVRCIHVFGGTGRRYASLGDQVIVSVKTAVPGGIVKKKDVCKAVVVRAVKESRRKDGSYIRFDENAVVILNAQGEPRGTRIFGPVARELRDKRYMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PICK1_HUMAN
Sequence: MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPSRDTRGAAGPLDKGGSWCDS
What is the function of this protein?
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence.  Involved in the clustering of various receptors, possibly by acting at the receptor internalization level.  Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors.  May be regulated upon PRKCA activation.  May regulate ASIC1/ASIC3 channel.  Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis.  Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD).  Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
What are the official names of this protein?
PRKCA-binding protein, Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Membrane; Lipid-anchor. Postsynaptic density. Synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Also membrane-associated, present at excitatory synapses.
Protein: Y637_PYRHO
Sequence: MIKMQVWKKLFAKSPFKPLIRHAEVVVQTVETLEKALDSWARGDYENMKEYAKKVDDLEDIADKIKSELRDSITSKLLMPVQRTDILEYLHMQDKIADAAEDTAKWLLIKRNLDSIPNDIKDIILKMGKESIKAAKLVYEAIKQLDNVLESGFAEKEIKKEYKIIKQIEEVESKIDGLDSKLMEIVFTSELDWKDGLYILNIARTLSNISDKAKDTAERIRVLMNK
What are the official names of this protein?
UPF0111 protein PH0637.
What is the protein family that this protein belongs to?
Belongs to the UPF0111 family.
Protein: RALB_MOUSE
Sequence: MAANKGKSQGSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKSEEDKIPLLVVGNKSDLEERRQVPVDEARGKAEEWGVQYVETSAKTRANVDKVFFDLMREIRAKKMSENKDKNGRKSSKSKKSFKERCCLL
What is the function of this protein?
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking.  Accomplishes its multiple functions by interacting with distinct downstream effectors.  Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity).  Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity).  Required for suppression of apoptosis (By similarity).  In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity).  Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).
What are the official names of this protein?
Ras-related protein Ral-B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=During late cytokinesis, enriched at the midbody.