PharMolix/UniProtQA huggingface dataset:
Protein: L_EMARV
Sequence: MENIRKLEAQRRKEYLRAETEIRNNNVFEKDILQKFLHIVGKKQRHYTISSKKKEVQDIFNKCSTNPGFTKDVIDLAERILYAPPNLNQIDFAMTIVSLIEMQRHDDLIHKLNELLVRSGMKVISFEFKLCDHFPFTNSILTPDILFEDPYGSRYILEVKVRNKHTDLEHYYMRYKKVVGVHAKVGVFNLSQSGYMQHGDYKLSEKINLESDDFDDILLCVELAGKIREKYIQYPQYFLYTLQSEVTNPDSFLDGFKTRLSDLSMFEEIKSGFGDYWNDITYHMDNYSLIDNHDEVTEDLLNSTDDLTQYCNDLYDEFLDHSQSYSRQGKYGKTILRNSGLDNIIDKKNRSKYTITSKLKPSVYIPITKTIKLDTYGGSRLKFYKDAFINIKCTGDSYSRSAYNLVDNVFNTSSIDLLMTKDDKIDPSLYYEVLDPGFIAHLHDDQVKYKKIAKVTNITSDMTILANNSFSIHCHTDQRLKDNICGYDKKHYDSTQKAKECLDFSNSSLLLPSLGVHLSAIFKSEHHAGVYWNDLVTLGTDNLNHMTSDIPEEAQTKFLEHLYNSHIIFKAIISLNTINSHKFRLLQSPDPGTIIILLPNSDGLKGAPLRYFVVSILQKQDNDSIEANKLLGIYHSHTESKKYKIMLSKVISLDITRLKLLSNSFVKYSLLISYYSQFKKSLKFDTHMLSWMLSQVTTIASLSITDVYKNFIMAIYSDYSNIDDLINDKLECRPRTLGHVFVMKHLFQGITSAVEQLGKINKNKLIADVNDEGELISTGFDPNLRLKLPISQLSTNNPKEIIHESFILFYLGNKGLHGSPQELLNLYYTPMQFESEYTKMMTDCGLYCQELGNNGNLSFSFQAMFLTSKVAYAKLLNNTDEIRRSLVKEMKMDEPIMSIKQFSSTKSMVSNSVPDMSIKDCNLNKNIDVIQLERYIDTSLISDPMKYITLMNNSIESINQERLLIYKDKLNKGIVLLPKLILTTFKGKSFIGLENHYYTKLVSGDYIKQTNTKVFDEFYRLTDEIQEEKLRGFYKGYITEGDLLVRIFNKDQRTTDDREIYTGNAQVRLCLYPLEMTFKSICKKIPEEAITISGDQKQRKLLEQRLALIKTKRQFNKSGYKTEIYSVSSDASKWSARDLLPKFIISIATNPYLTSDEKYFLVYLLVRYYDKKIVLTDSAFSNALRFSREDINGKYEEMTNNFTQNWFNVRSNWLQGNLNMTSSFVHHCSTIMTDTLLSISAKHNGFEAVMTSMVHSDDSTYDFLIAKNSKTSSYINNEANMGRFIISLITYSNKKHCITLNEKKTYISTFYKEFLSTTIVSNELFFFYMADLMPISSDTSYKSPLEDLASYTGYINNSFSHACPIQILKCAITLLNHLTLSTYNMQYTSEKNPRCNIPNSTDLPIQIYPRYKLPLSLAGCIPYYSSDAYNILDDIIKTLEKNKVIKNSLLEDVIDDETLDEYITLVNKQKPEYAKYIQACLLTMDYTQYERDDEDPYNIVDYDLSQKSIINVASINKGSRIKKTYTYKKYLENETDIRLTSCVNPMWCISKPKDEVLIKNPILANYMNPNFKDSLIFSKSALDYGRRIIGSNKSMDTLSSHAFEKEKKQGIKTIYKKLDDKISTVEISKQSLQRFLECIYSVIKKSLVALQVYYSKVQVLVKTRPEFTKVIMPRSVYAEEYGKNSNTSMVENLLVEQYCEIEQVDSKVEKFISFCKHVLQRCGDIKIYRDPEDIDDDFRKYIEFKYTLKDATMGLIQPHQHLAEYAFDVYNNKLIFQGLMVRYYIDICETISNPSYNIPSYTSPNSIIMTLDSLMKRDEISSKIYISHIRTNRFDEYWLSRFGMYVYENYFVKYKLGYRIKIAANEKLMPTMKKVRNLREPFKFICSLVANDPSLFIQMTESPDFQISGWKYSDIIAEMKSTTDFSYNLFLYMMNEINFQTLMRVMNLNRRVWNHWLMKTDSEPSDPNASIALYMYQSTVVKVQTKTIGGGVTFSMLLLRHGMQHRQAFDEISKKIASDYAPQLRIANITPQTSFGRLQFCVNEYGRTVKPGSYRSSCICNVNIAALTDLKPDIAYKENTINQIVTIISPTFEGEFVFKLNTYCDSEYYTCVMLENLDLNRVMILDHLCRGKYLIENPEYFTEISDQITPGACLALFSNNVNNKLWSNTIDTSKFAKLVHIGNYLKTEHEASIVTKLCDSLVAICALNGIDHTLSLKPDNFIKSLRQYKLSYGFHEEFYNNYKKNEREPYTELIMAIASTAGDPFQKVILAIITIFKAYTDLFISYKTDEVEF
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome.
What are the official names of this protein?
RNA-directed RNA polymerase L, Protein L, Large structural protein, Replicase, Transcriptase.
Protein: NDHK2_ACAM1
Sequence: MKPQSLEANIINPITPLEVTQELSDNVILTALDDLYDWVKMSSLYPFMFGTACCFMEFMGAYASRFDMERFGMIPRATPRQADLLITAGTITMKYAPALVRLYEQMPEPKYVMAMGACTITGGMFSADSPSAVRGVDKLIPVDVYIPGCPPRAEAVLDAITKLRKKIANESLQERDTTQQTHRYYSIPHKMKVVPPAVTGQYLQSHEVA
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K 2, NAD(P)H dehydrogenase I subunit K 2, NDH-1 subunit K 2, NDH-K 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MBTG_MYCTO
Sequence: MNPTLAVLGAGAKAVAVAAKASVLRDMGVDVPDVIAVERIGVGANWQASGGWTDGAHRLGTSPEKDVGFPYRSALVPRRNAELDERMTRYSWQSYLIATASFAEWIDRGRPAPTHRRWSQYLAWVADHIGLKVIHGEVERLAVTGDRWALCTHETTVQADALMITGPGQAEKSLLPGNPRVLSIAQFWDRAAGHDRINAERVAVIGGGETAASMLNELFRHRVSTITVISPQVTLFTRGEGFFENSLFSDPTDWAALTFDERRDALARTDRGVFSATVQEALLADDRIHHLRGRVAHAVGRQGQIRLTLSTNRGSENFETVHGFDLVIDGSGADPLWFTSLFSQHTLDLLELGLGGPLTADRLQEAIGYDLAVTDVTPKLFLPTLSGLTQGPGFPNLSCLGLLSDRVLGAGIFTPTKHNDTRRSGEHQSFR
What is the function of this protein?
Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration.
What are the official names of this protein?
L-lysine N6-monooxygenase MbtG, Lysine 6-N-hydroxylase, Lysine N6-hydroxylase, Lysine-N-oxygenase, Mycobactin synthase protein G.
What is the protein family that this protein belongs to?
Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.
Protein: RL7_SALRD
Sequence: MADIEELAEQLVGLTIQEANELANHLEEEYDIQPASAGVAVAADGGGGADGDAEEEEQTAFDVVLTGIGGNKIQVIKEVRSITGMGLKEAKSLVDEAPNPVSEGVSREEADDLKAQIEDAGGEVELQ
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: DAPAT_SYNR3
Sequence: MALVNGNYLKLKAGYLFPEIGRRVKAFSEANPDAALIRLGIGDVTEPLPQACRDAMKNAIDEMGTREGFHGYGPEQGYAWLREAIAKHDFQSRGCDISAEEIFVSDGSKCDSSNILDILGEGNRIAVTDPVYPVYVDSNVMAGRTGDANEGGQYGGLSYLPITAANDFTAPLPSTPVDLIYLCFPNNPTGAVASREQLKSWVDYALEHKALILFDAAYEAFIQDPAIPHSIFEIEGARQCAIEFRSFSKNAGFTGTRCALTVVPKGLMGTSATGEQVELWGLWNRRQSTKFNGVSYIVQRGAEAVYSEQGQAEVKALINFYMENAAIIRRELSAAGLTIYGGEHAPYVWIKTPEGMDSWGFFDHLLNRANVVGTPGSGFGAAGEGYFRLSAFNSRSNVDEAMRRIRAL
What is the function of this protein?
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis.  Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
What are the official names of this protein?
LL-diaminopimelate aminotransferase, DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
Protein: RL30_ACIC1
Sequence: MPRLKVTQVRSGIGGTAEQRDTLRSLGLKRLRDTVVKEDRPEIRGMIRAVAHLVRVEEVE
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RL4_SHIBS
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RS9_PIG
Sequence: VARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAXSIHHXRVLIRQ
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: HUTI_PORGI
Sequence: MPNTPHTMNLYIKNIAQLVTCQGSEAKHGREAMGQIHTIEGPAAVVIRDGIIAFAGRMADVAPSMTEGCRELDATGRCVLPGFVDSHTHLVFGGYREDEFQWRLAGDSYMSIMERGGGIASTMRATRSESEDELKASARRHLSNMMKMGVTTVEAKSGYGMNLETELKQLRVVRDLQDEQPLDLYSTFMGAHDTAPEYKGRPTEFIEYLCREVLPEVVRQNLAECCDIFTEKGVFDHEQTRRMLTAAKEAGLSVKMHADEIVPFGGAELAAELGCLSADHLLRISDAGIKALAESNTVATLLPCTAFSLRADYAPARKMIDAGCAVALGSDLNPGSCFSASVPLMFALATLYMGMTVEEAITALTINGAAAIGRADTIGSIEPGKKGDLVVLQYPSYKFLSYHFGMNLVEHTVKGGRVVYTNS
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAG6_PIG
Sequence: MEPNDSTSTTMEEPESLEVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNVGGKVIHLVERAPPQTQLPSGASSGTGSASATHGGGPPPGTRGPGASVHDRNANSYVMVGTFNLPSDGSAVDVHINMEQAPIQSEPRVRLVMAQHMIRDIQTLLSRMECRGGSQAQHSQPPSQMPTVAPEPVALSSQTSESVESEVPPREPMAAEEVEERASAQSPGLSPSGPAPAGPTPAPETNAPNHPSPAEYVEVLQELQRLESRLQPFLQRYYEVLGAAATTDYNNNQEGREEDQRLINLVGESLRLLGNTFVALSDLRCNLACAPPRHLHVVRPMSHYTTPMVLQQAAIPIQINVGTTVTMTGNGTRPPPTPNAEAPPPGPGQASSLAPSSTTVESSTEGAPPPGPAPPPAASHPRVIRISHQSVEPVVMMHMNIQDSGTQPGGVPSAPTGPLGPTGHGQTLGQQVPGFPTAPTRVVIARPTPPQSRPSHPGGPPVSGALPGAGLGTNASLAQMVSGLVGQLLMQPVLVAQGTPGMAPPPAPATASASAGTTNTATTAGPAPGGPAQPPPPQPSASDLQFSQLLGNLLGPAGPGAGGPGMTSPTITVAMPGVPAFLQGMTDFLQATQTAAPPAPPPPPPPPPPAPEQQTAPPPGSPPGGAGSPGGLGPESLPLEFFTSVVQGVLSSLLGSLGARAGSSESIAAFIQRLSGSSNIFEPGADGALGFFGALLSLLCQNFSMVDVVMLLHGHFQPLQRLQPQLRSFFHQHYLGGQEPTPGNIRTATHTLITGLEEYVRESFSLVQVQPGVDIIRTNLEFLQEQFNSIAAHVMHCTDSGFGARLLELCNQGLFECLALNLHCLGGQQMELAAVINGRIRRMSRGVNPSLVSWLTTMMGLRLQVVLEHMPVGPDAILRYVRRVGDPPQPLPEEPMEVQGSERTSPEPQRENASPAPGTTAEEAMSRGPPPAPEGGSRDEQDGAAAETEPWAAAVPPEWVPIIQQDIQSQRKVKPQPPLSDAYLSGMPAKRRKTMQGEGPQLLLSEAVSRAAKAAGARPLTSPESLSRDLEAPEVQESYRQQLRADIQKRLQEDPNYSPQRFPNAHRAFAEDP
What is the function of this protein?
May mediate ricin-induced apoptosis.
What are the official names of this protein?
Large proline-rich protein BAG6, BCL2-associated athanogene 6, HLA-B-associated transcript 3.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Secreted, extracellular exosome. Note=Normally localized in cytosol and nucleus, it can also be released extracellularly, in exosomes, by tumor and myeloid dendritic cells.
Protein: PURK_VIBVY
Sequence: MHVLVLGAGQLARMMSLAGAPLNIQISAYDVTTGDVVHPLTLHLLGHGLEQAIEHVDVITAEFEHIPHDILAICQASGKFLPSSEAIKAGGDRRLEKTLLDHAGVRNANYYVIETREDFNKAIEHVGIPMVLKSALGGYDGRGQWRLKDAAQIETLWQEMAACIAATPTQAIVAEEFVPFQREVSLIGARGKEGQIEVYPLAENIHVNGVLSLSTAIDSPDLQEQAKHMFTAVAETLNYVGVLALEFFDVDGQLLVNEIAPRVHNSGHWTQQGAETCQFENHLRAVCGLPLGSTKLVRETSMINILGEDTLPASVMAMDGCHIHWYGKEKRAGRKMGHINVCGDYSGELQRRLCALANVLDEKAFPAVHEFAKKWQA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
What are the official names of this protein?
N5-carboxyaminoimidazole ribonucleotide synthase, N5-CAIR synthase, 5-(carboxyamino)imidazole ribonucleotide synthetase.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: Y579_TREPA
Sequence: MIRPRYGWMYSSGIAVHLCAAVCAHSAVPAAWTFAEQTQAQKTDTPLDSSSYAVTSPEEAPNEADPFEKELEHAFERAHVSTGGADSSSHADFVHMEEAGRAHASANRWYHETFDSRQRPSSAVLYEGAQLLHTVHWHYVGDRLFPCEKIITTPHTRIRARYNFSGKIVAYEMHTRGVLVYARTYRYDAHARICEKEETTARGNERITYEYRGKVDVLEKRYRNGVLQAIIHQKEGAQDVQVFERGKEIYSTKEVHDE
What are the official names of this protein?
Uncharacterized protein TP_0579.
Protein: AIM2_HUMAN
Sequence: MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT
What is the function of this protein?
Also acts as a tumor suppressor independently of its role in inflammatory response (PubMed:16432157).  Able to suppress overt cell proliferation in enterocytes: restricts stem cell proliferation in the intestinal mucosa in an inflammasome-independent manner, contributing to a decrease in the likelihood of colorectal cancer development (By similarity).  AIM2 suppresses cell proliferation by inhibiting phosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity).  Inhibits AKT1 phosphorylation both by inhibiting the activity of PRKDC/DNA-PK kinase and promoting dephosphorylation by PP2A phosphatase (By similarity).  Also acts as a key regulator of regulatory T-cells (Treg) homeostasis by promoting their stability: acts by preventing AKT1 activation (By similarity).  Its role in Treg homeostasis is important to restain autoimmune diseases (By similarity).
What are the official names of this protein?
Interferon-inducible protein AIM2, Absent in melanoma 2.
What is the protein family that this protein belongs to?
Belongs to the HIN-200 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Protein: MATK_TRIUN
Sequence: MEELQGYLEKDGSRQQNFLYPLIFQEYIYTLAHDHGLNSSIFYEPMEIVGLGYDNKSSSVLVKRLITRMYQQNSLIYSMNDFNQNLFVGHNNSFYSHFYSQMVSEGFAVIVEIPFSLRLVPSSEEIPKSQNLRSIHSIFPFLEDKLSHLNYVLDILIPYPIHLEILVQILQCWIQDVPSLHFLRFFLHEFHNWNNFLTPTKSISVFSKENKRLFRILYNSYVSEYEFVFFFLRKQSYYLRSTSSGAFLERTHFYVKIEHLIDVCHNHFQKILWFFKDSFMHYVRYKGKAILASRGTYLLIKKWKCYLVNFWQYYFHFWSKPYRIHINPFSNYSFYFLGYISSVLINPSAVKNQMLENFYLVDTLTQKFDTIVPVIPLIGSLSKAKFCTILGHPISKPIWAELSDSDIIDRFGRICRNLSHYHSGSSKKQSLYRIKYILRLSCARTLARKHKSTVRNLLQRLGSGLLEEFFTEEEQVISPIFPKTTLFPLHGSHRERIWYLDIIRINDLANYLDWS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AGB34_AGAAL
Sequence: MKGFTKHSILMACSIGLAINATAADWDNIPIPAELDAGQSWELQQNYSDSFNYSGKNSTFTGKWKDSYFHSWTGPGLTHWSSDESWVGDGNLIISASRRQGTNKVNAGVITSKTKVKYPIFLEASIKVSNLELSSNFWLLSENDQREIDVLEVYGGARQDWYAKNMSTNFHVFFRNNDNSIKNDYNDQTHFTPTWGNYWRDGFHRFGVYWKSPTDVTFYIDGQKTTKGAWSQVVMKDKDYTGAILDKSRYNMDQEAFIIIDTEDHSWRSEAGHIATDADLADSDKNKMYVDWIRVYKPTGGSTTPPTGDITPPSGYTNLQLAHSNRCVDVINGALWNGSTYQQYSCNTGNNNQRFKFTKIANNQYSINAKVSQLCMELASGSSANGAKVQQWICNHANSNQTWSLEDKGSNTFEIRNKQSGKCLEVANSSNANGGQIRQWACTGATNQRFKFL
What are the official names of this protein?
Beta-agarase AgaB34.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NAPA_BRADU
Sequence: MTSPKLDRRQMLKLEAAAIAAAAAGLPVPALAANLATEREVSELKWDKAACRFCGTGCSVMVATKENRVVATHGDIKAEVNRGLNCVKGYFLSKIMYGHDRLTQPMLRKANGKYDKNGDFTPVSWTEAFDIMEVKWKEAMKKRGPNGVAMFGSGQWTIWEGYAASKLFKAGFRTNNIDPNARHCMASAVAGMMRTFGIDEPPGCYDDIEATDAFVLWGSNMAEMHPILWTRLTDRRLSAPHVRVAVLSTFEHRSFDLADIGMVFKPQTDLYLLNAIANHIIKTGRVNKDFVAAHTVFRRGQTDIGYGLRPEHPLQKKATGAAKANDSTDMSYDEYVKFVSEYTLEKAAEMSGVPLNRLEALAELYADPKTKVVSFWTMGFNQHTRGVWCNNLVYNIHLLTGKISSPGNSPFSLTGQPSACGTAREVGTFSHRLPADMVVTNKEHRTKAEHIWQLPEGTIPDKPGAHAVLQSRMLKDGLINAYWVQVNNNLQAGPNANEETYPGFRNPDNFIVVSDAYPSVTALAADLILPTAMWVEKEGAYGNAERRTQFWHQLVPAPGESKSDLWQLMEFSKRFKIEEVWPEELIAKKPEVRGKTLFDVLYKNGQVDKFPVSDIEQGYLNDESKAFGFYVHKGLFEEYASFGRGHGHDLAPFDAYHKERGLRWPVVNGQETRWRFREGSDPYVKQGTDVQFYGYPDGKARIFALPYEPAAESPDGEYPFWLSTGRVLEHWHSGTMTRRVPELYKAFPEAVCFMHPDDAQEAKIRRGDEVKVVSRRGFIRVRVETRGRDRPPRGLVFVPWFDESKLINKVTLDATDPISLQTDFKKCAVRIERVNVS
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: LFG3_HUMAN
Sequence: MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN
What is the function of this protein?
Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.
What are the official names of this protein?
Protein lifeguard 3, Protein RECS1 homolog, Transmembrane BAX inhibitor motif-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the BI1 family. LFG subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Lysosome membrane. Endosome membrane.
Protein: PGRC1_MOUSE
Sequence: MAAEDVVATGADPSELEGGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPGASGDNDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLSDWDSQFTFKYHHVGKLLKEGEEPTVYSDDEEPKDETARKNE
What is the function of this protein?
Component of a progesterone-binding protein complex.  Binds progesterone.  Has many reported cellular functions (heme homeostasis, interaction with CYPs).  Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (PubMed:28005395).  Intracellular heme chaperone.  Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).
What are the official names of this protein?
Membrane-associated progesterone receptor component 1, mPR.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b5 family. MAPR subfamily.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side.
Protein: TMCAL_STRP2
Sequence: MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAIVDKWTRAQMALENGADLVVELPFLVSVQAADFFGQGSVDILDRLGIDSLAFGTEEVLDYQKIADLYTEKGAEMEKFVKNLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYAKAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQASKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVELVTTKRYTKARVRRLLTYILMQARESDLPEAIHVLGFTEKGRQHLKSLKGQVSLVSRIGKEPWDAMTQKVDQIYQLGKPSIAEQNFGRVPIRIETN
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUFA_HALSA
Sequence: MHRGRFATLVIVALAVTMTAPAGALAPQPPAQHADADRACSFPVTEPDASNTAITLDSEPERVVTLNPSAAQTMWELGDRDAVVGVSQFGTYLPTASQRTVVSGGQPSQTNVEAVVGLDPDLVLAPNTVRNTTVTRLRSAGITVFQFRAATSIDGVVEKTATIGRLTGNCAAAAATTAEMRDRVAAIADAVPDTDSARPRVYYHLGDGYTAGPNTFIGAAIEAAGGHNIAADVNTTSSYPQLSEEVIVSQDPDVVVTGVSADRLDATASALVAPSSVVRNTTAYATGNVVAVNTNHINQPAPRIVEPMARMANAFHNTTINTTLDAQPSATTTATSTAPPTDAADGTAPGFGVAAAVCALAGAALVARR
What is the function of this protein?
Required for corrinoid utilization.  Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import.  Probably binds cobalamin and delivers it to the surface of BtuC.
What are the official names of this protein?
Cobalamin-binding protein, Vitamin B12-binding protein.
Protein: RS16_LEGPA
Sequence: MVVIRLSRAGAKKRPFYHMVVTDSRKRRDGNYIERIGYFNPVARGQEVKLHIDMDKMTHWQKVGAQLSDRVSALLKEHSKKSETAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: QUEC_HALSA
Sequence: MSAKRAVVLASGGMDSATAAAVAHNAGYEVYMLHTSYGQQTEHKEHECATAQAAALGAADFLHLTTDHLSKIGASSLTDDEMAVADADMESDEIPTSYVPFRNANLLAMATSYAEANDCEAVFIGAHSEDFSGYPDCQPAFFEAFQQTVAAGTKPDTEISINAPFVDWSKTDIAERGLELGVPYEHTWSCYRAEAPACGTCDACAFRLQAFQNLGERDPIEYAERPSYT
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, Archaeosine biosynthesis protein QueC, PreQ(0) synthase.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RUVB2_YEAST
Sequence: MSIQTSDPNETSDLKSLSLIAAHSHITGLGLDENLQPRPTSEGMVGQLQARRAAGVILKMVQNGTIAGRAVLVAGPPSTGKTALAMGVSQSLGKDVPFTAIAGSEIFSLELSKTEALTQAFRKSIGIKIKEETELIEGEVVEIQIDRSITGGHKQGKLTIKTTDMETIYELGNKMIDGLTKEKVLAGDVISIDKASGKITKLGRSFARSRDYDAMGADTRFVQCPEGELQKRKTVVHTVSLHEIDVINSRTQGFLALFTGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFAPIVMMATNRGVSKTRGTNYKSPHGLPLDLLDRSIIITTKSYNEQEIKTILSIRAQEEEVELSSDALDLLTKTGVETSLRYSSNLISVAQQIAMKRKNNTVEVEDVKRAYLLFLDSARSVKYVQENESQYIDDQGNVQISIAKSADPDAMDTTE
What is the function of this protein?
DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.  The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.  The INO80 complex remodels chromatin by shifting nucleosomes.  Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates.  The INO80 complex is involved in DNA repair by associating to 'Ser-129' phosphorylated H2A histones as a response to DNA damage.  During transcription may recruit SPT15/TBP to the TATA-boxes of involved genes.  Required for box C/D and box H/ACA snoRNA accumulation and involved in pre-rRNA processing.
What are the official names of this protein?
RuvB-like protein 2, RUVBL2, TIP49-homology protein 2, TIP49b homolog.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: NORV_SALTI
Sequence: MSILVKNNIHWVGQRDWEVRDFHGTEYKTLRGSSYNSYLIREEKNVLIDTVDHKFSREFVQNLRSEIDLADIDYIIINHAEEDHAGALTELMAQIPDTPIYCTANAIDSINGHHHHPEWNFKVVKTGDTLDIGDGKQLIFVETPMLHWPDSMMTYMTGDAVLFSNDAFGQHYCDEHLFNDEVDQTELFEQCQRYYANILTPFSRLVTPKITEILGFNLPVDMIATSHGVVWRDNPTQIVELYLKWAADYQEDRITIFYDTMSNNTRMMADAIAQGINEVDPNVAVKIFNVARSDKNEILTNVFRSKGVLVGTSTMNNVMMPKIAGLVEEMTGLRFRNKRASAFGSHGWSGGAVDRLSTRLQDAGFEMSLSLKAKWRPDLDALELCRQHGRDIARQWALAPLPETTQKTAPVEETTTCTAADLGPKMQCSVCQWIYDPALGEPLQDVAPGTPWSDVPDNFLCPECSLGKDVFDVLATEAK
What is the function of this protein?
Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes.  Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified.  NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center.  Also able to function as an aerobic oxygen reductase.
What are the official names of this protein?
Anaerobic nitric oxide reductase flavorubredoxin, FlRd, FlavoRb.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.
What are the subcellular locations of this protein?
Cytoplasm.