PharMolix/UniProtQA huggingface dataset:
Protein: CH10_STRP6
Sequence: MLKPLGDRVVVRFDDEKEQTVGGFVLAGTHKESTRKATVLAVSETGVRTITGDSVLPSVSVGQEVLVENGHDLEVTVDDEKVSIIRESDIIAIVTK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISCA_SALG2
Sequence: MSITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTAEDTVFEDKGVKVVVDGKSLQFLDGTQLDFVKEGLNEGFKFSNPNVKDECGCGESFHV
What is the function of this protein?
Is able to transfer iron-sulfur clusters to apo-ferredoxin.  Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically.  Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
What are the official names of this protein?
Iron-binding protein IscA, Iron-sulfur cluster assembly protein.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: ASCC2_MOUSE
Sequence: MPALPLDQLQITHKDPKTGQPKTSAALNPEQKADRYFVLYKPPPKDNIPALVEEYLERANFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLHYVPRKFDEWVAPTPEVADMQNHLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYTDLDETIPTILQVFSNILQHCGLQGDGTSTTPQKLGERSPLTPSDMPLLELKDIVLYLCDTSTTLWAFLDIFPLACQTFQKHDFCYRLASFYEMAIPELESAIKKRRLEDSKLLGDMWQRLSHSKKKLMEVFHIILNQICLLPILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDTFSPVAEDISLLQQASSALDETRTAYILQAVESAWEGVDRQKIKDIKDPPRAKGSNNEVTVTAEPVSEMPSQLENLEEDEECMGAAAALGPAVSGVELDSLISQVKDLLPDLGEGFILACLEHYSYDSEQVINNILEDRLAPELSQLDRGLERQVKPDPTPLLSSRHNIFQNDEFDVFSRDSVDLSRVHKGRRKEENVRSLVNDKQAVVAQWQRYQKYSVVVEEVPLQPGEYQADDYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTKMPGEVQEEEWDEEDEVEEEAPKPDHFIQDPAVLREKAEARRMAFLARKGYRPENSTAVTGGPRGHGQSRETTQERRKKEANKAARANHNRRTMADRKRSKGMIPS
What is the function of this protein?
Plays a role in DNA damage repair as component of the ASCC complex (By similarity).  Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (By similarity).  Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (By similarity).  Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (By similarity).  As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes (By similarity).
What are the official names of this protein?
Activating signal cointegrator 1 complex subunit 2, ASC-1 complex subunit p100, Trip4 complex subunit p100.
What is the protein family that this protein belongs to?
Belongs to the ASCC2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Note=Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage.
Protein: CC184_MOUSE
Sequence: MEDSLLEIMTKDGGDMPAPLEVSTVPAVGDVISGEYNGGMKELMEHLKAQLQALFEDVRAMRGALDEQASHIQVLSDDVCANQRAIVSMCQIMTTAPRQGGLGVAGGKGSFPSVPHEPETPSPGIEDSGLLGRDPDEDEDEEEKETPNPATPTSHCELSESPGLLGEDGPLVEPPDLPDITLLQLEGEASL
What are the official names of this protein?
Coiled-coil domain-containing protein 184.
Protein: RHAT_SALTY
Sequence: MSNAITMGIFWHLIGAASAACFYAPFKQVKQWSWETMWSVGGIVSWLILPWTISALLLPDFWAYYGQFNLSTLLPVFLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIVGTLMTPIINGNFDVLIHTEGGRMTLLGVFVALIGVGIVTRAGQLKERKMGIKAEEFNLKKGLLLAVMCGIFSAGMSFAMNAAKPMHEAAAALGVDPLYVALPSYVVIMGGGALVNLGFCFIRLAKVQNLSIKADFSLARPLIISNILLSALGGLMWYLQFFFYAWGHARIPAQYDYMSWMLHMSFYVLCGGLVGLVLKEWKNAGRRPVAVLSLGCVVIIIAANIVGLGMAS
What is the function of this protein?
Uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell (symport system).
What are the official names of this protein?
L-rhamnose-proton symporter, L-rhamnose-H(+) transport protein.
What is the protein family that this protein belongs to?
Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COXX_NITEC
Sequence: MSTNPLVWQQATVRIQQFYRLTKPRVVSLIVFTAVIGMFLSVPGAVPLDKLLLGTIGISLVAGAAAALNCLVEYKFDAIMARTKGRPLPQGKVSVPETLFFLVMVGGLGLFILHQWINPLTMWLTLGTFVGYAIIYTVILKPLTPQNIVIGGASGAMPPVLGWAAITGEISADALLLFLIIFAWTPPHFWALALYRKSDYAKIGMPMLPVTHGEEFTRLHVLLYTIILCIATVLPYLTQMSGLIYLVSVLILDAIFLYYAIRIYLHYTDQIAREAFRYSIIYLALLFTALLVDHYFYF
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TYSY_BRASO
Sequence: MHQYHDLLERILSDGAQKHDRTGTGTLSVFGHQMRFNLAAGFPMVTTKRLPLKAIVHELLWFLKGDTNIKYLHDHGVTIWDEWADANGDLGPVYGYQWRSWPTSDGGQIDQISNVVDMIRRNPDSRRLIVTAWNPADVEKMALPPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKLGEFVHSFGDVHLYSNHIEQARLQLSRTPRPLPTMTLNPDVKDIFAFRYEDFALAGYDPHPHIKAEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1152_METJA
Sequence: MVIMKKHVKRIVKKYLGSKKAESEEEDILPDWIVKVKNEIENITYEEYVKDVDKFFNEVKKKGIEKVLFDDIK
What are the official names of this protein?
Uncharacterized protein MJ1152.
Protein: MOTA_BACSU
Sequence: MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTISAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIEDVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVLGAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKLREVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA
What is the function of this protein?
MotA and MotB comprise the stator element of the flagellar motor complex.  Required for rotation of the flagellar motor.  Probable transmembrane proton channel (By similarity).
What are the official names of this protein?
Motility protein A, Chemotaxis protein MotA.
What is the protein family that this protein belongs to?
Belongs to the MotA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL5_RALPJ
Sequence: MTARLQEFYKEKVVPELIKQFGYKSVMEVPRITKITLNMGLGEAINDKKVIEHATGDLIKIAGQKPIVTKARKAIAGFKIRQGYPIGTMVTLRGQRMYEFLDRFITVSLPRVRDFRGVSGKAFDGRGNYNIGVKEQIIFPEIEYDKIDALRGLNISITTTAKNDEEAKALLNAFKFPFRN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RL17_BACC7
Sequence: MAYRKLGRTSAQRKAMLRDLATDLIINERIQTTETRAKELRSVVEKMITLGKRGDLHARRQAAAFIRNEVANAETGQDALQKLFADVAPRYAERQGGYTRIAKIGPRRGDAAPMVIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: XPT_BIFAA
Sequence: MKELEERIVQQGTVKPGNVLKVDAFLNHQCDVELFDHMGAAWAEHFKGKTIDKILTIEASGIGIACVVARHFGNVPVVFAKKAQSINLDGDQYTTTVYSFTKQKEFPVIVSKRYLNEGDHVLLIDDFLANGKALKGLIELCHEAGATVEGIGIAVEKGFQGGGDQLREEGYDVDSLAIVESMDPENGTIEFRS
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATR1_USTMA
Sequence: MRFRSDSRADHQHPKKQGSMDPDTIQALKYQDRSSSSSSNNKPKEKVGSASTSPSPTLFASNDSVKVEIGVGSSDKEKPDVKVSFFTIFRYASKRQLLINLFGTGMAIAAGAAQPLMNIFIGKIATVFLHFTSAIRSGDLDAIRAAHSDVYSTINSDALILLYLGIGMFFASMLYMAVFSYTSERIASNIKYAYLSSLFSKPIDFFEQCGQGTVAAKIGSDVHLIQIGIGEKLPMAIMYFSTFVTAAAVAFAFSWRLSLVLLPIAPLILLAGGVMGALTKGCKLVELDCIAKAASRAEEAFNAIKILKAFSKERTIGQEYDTLTTDTKAAGAKAGRIQGVGVGALLFIIYAGYALAFFYGAQLIARGELLPGRIVSVVFANFAGAFAIANLFSMIENFTMATAAASSVIGTIQQDLASSELSESRRNEEKSQTSRQLATGYNAELKLDHVHFAYPSKPERPVLKDLSLTIPSCVTTAIVGLSGSGKSTIFALLQRFYAPTRGSIRLDDVDISALDVDWLRGQIGVVEQQPTLFAMSIQANIELGLPNRHTRSAEELESLVVQAAKKANAHNFITALTHGYQTEVGSQGFLLSGGQKQRIAIARALIRDPKILLLDEATSALDSKSEAVVQAALDEAAKDRTTIIISHRLSTVRNADNIVVLGPDGIIEQGSHHELSIKPNGTFASMLRHQDDKTKPVMVTSEPEIVDSSHSLCLTEIPTMEIAHSLEVSRTISALADSVKPKDPSKNFEPPGESYASPAADGVKQDAPKTDSVGLRTLLHILIKDPETGRLAQLYMLGSLCAAIIGAVYPVYAILFGTAIEDYAPCNSSDGRPCPNPARGTMLHNNRISSGSFFIVAVGCAFISFYHVRSLYIAGSRVTHRLRVLVFQSLLCLDASFFDDPVNTSNDLASSLSVLSQGIYGGVGPTLGSIVQSLATVIVGYAVAIGYGWRLALVVIASTPLTITAGLLRLRVLARKESKTKQAHQHTTQQACESIGAIRTVSAFNLQPQTLQVYQKNLENASRSLRPTMCYSSVLFGLSQCVQLLVTALAFWYGGRELAQGHTSSKGFFTILISVVYGSVQAGNIFNYSADFSSAHSAACKSLSILKQAKEVVAEAQANDRDVQWNTEDSLPSGQIALKEVTFRYPQRPTCTVLDRLSLTIEPGTFCAIVGGSGSGKSTVLQLIERFYTPESGRVLLDGYSITEGDPARFRKYMSYVPQEPTLFQGTIGWNIALGATDENPEDVPLAKIQQAAELAQLGDLLASLPEGLNTQLSARGVQMSGGQKQRIAIARAMIRDPRVLLLDEATSALDPASERAVQGALDNVSQGRTTIAVAHRLSTIAKADKVIVMQAGKVVEEGSPRELFQRDGLFALMARLQGVSF
What is the function of this protein?
ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA) (PubMed:17850255).  UA is a secreted cellobiose glycolipid that is toxic for many microorganisms and confers biocontrol activity to U. maydis (PubMed:17850255).  Export of UA is presumably catalyzed by the ABC transporter atr1 (Probable).  Atr1 appears to be quite unspecific, as many of the UA derivatives produced by cluster mutant strains are readily exported (Probable).
What are the official names of this protein?
ABC-type transporter atr1, Ustilagic acid biosynthesis cluster protein atr1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TTCA_STRMK
Sequence: MSAVISLPDPQPRAARDPRVAEREQHKLAKRLRRQVGEAIADFGMIEAGDKVMVCLSGGKDSYTLLDVLLQLQKKAPVPFELVAVNLDQKQPDFPEHVLPEYLAGLGVPYHIIEQDTYSVVSRVIPEGKTMCSLCSRLRRGALYNYAETHGFTKIALGHHRDDMVATFFMNLFHHAKLSGMPPKLRSDDGKHVVIRPLAYVRESDIVDYAQARQFPIIPCNLCGSQENLQRRQVGLMLKQWEKDHPGRIEQIARAMGEVRPSQLADTTLFDFMALGRRDDAPLPDAHAWLAGSPADADADPETPTV
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_KINRD
Sequence: MHCPFCRHDDSRVVDSRTTDDGSSIRRRRQCPNCSKRFSTVETASLSVIKRSGAPEPFSRAKIASGVRKACQGRPVSEDDIALLAHRVEEAVRAQGAAEIDAHQVGLATLPFLQELDEVAYLRFASVYQAFDSLADFESAIDRLRAQRAAVAVPPVEPVAARG
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: TRPB_BORPA
Sequence: MKPYDLPDARGHFGPYGGVFVAETLMHALDELRAAYDQCRVDPSFIDEFNYELKHFVGRPSPVYHASRWSQRLGGAQIWFKREDLNHTGAHKVNNCIGQALLARRMGKPRVIAETGAGQHGVATATVAARYGMECVVFMGSEDVRRQASNVYRMKLLGATVVPVDSGSRTLKDALNEAMRDWVTNIENTFYIIGTVAGPDPYPRMVRDFQTVIGQECLTQMPEVIGRQPDYVVAAVGGGSNAMGIFHPYIPYENVRLIGVEAAGEGMETGRHAASLAAGQIGVLHGNRTYVMQNADGQVQETHSVSAGLDYPGVGPEHAWLKDSGRAEYAGITDDEALAAFHDCCRIEGIMPALESAHAIAQAVKMAPALSKDKVILVNLSGRGDKDMHTVAERAGLQL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: GHRA_SALDC
Sequence: MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAVFALGAGGDAILSKLNAHPEMLDASIPLFRLEDTGMGLQMQEYAVSQVLHWFRRFDDYQALKNQALWKPLPEYTREEFSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGVESYVGREELHAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAALDSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_STRPN
Sequence: MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRDVRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENELLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLVVNVPDFIEAGQKLVINTAEGTYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F241B_HUMAN
Sequence: MVRILANGEIVQDDDPRVRTTTQPPRGSIPRQSFFNRGHGAPPGGPGPRQQQAGARLGAAQSPFNDLNRQLVNMGFPQWHLGNHAVEPVTSILLLFLLMMLGVRGLLLVGLVYLVSHLSQR
What is the function of this protein?
May play a role in lysosome homeostasis.
What are the official names of this protein?
Protein FAM241B.
What is the protein family that this protein belongs to?
Belongs to the FAM241 family.
What are the subcellular locations of this protein?
Membrane; Single- pass membrane protein.
Protein: HACL2_CAEEL
Sequence: MVLFLIIAAIIIGLLLWKWLDVRSTDELTSMVKLLGSGNGQHVLSNAFQVDEKSKRHGGELVASVLKAHDVEEIFVLCGGHISPILVAAEKLGIKIVDTRHEVTAVFAADAVARLRQSIGVAAVTAGPGLTNTITAVKNAQMAESPLLLIGGAAPTLLKGRGALQDIDQMVLFRPLCKYVARVERLRDIVPTVREAIKAAKSGCPGPVFVEFPVDVLYPYELVVKEIGFNPNAKGFIQRALNFYLRCHVSRQFGNAWAPQTITPLPTNIPMPKSEKIQEIVQLVKSAKRPVLLIGSQATLPPVKPADLVKAVEALGCPVFLGGMARGLLGKDHPLQMRQVRRDALKDADLTILAGTVCDFRLSYGRTLSKKSKIVALNRNSSQLTKNEKAFWNSDVSVQADVATSLVQVANALGANHTTTPTEWVKSLREKDDEKESANAKKMEQKLTNGFLNPLNFLRTLDQSLPDDAILVADGGDFVGSAAYIVRPRGPLQWLDPGAFGTLGVGGGFALGAKTVYPKRPVYIIWGDGSCGYSLMEYDTFARHKLPVIGIVGNDACWTQIAREQVPMFQSSVAVDLARTRYDNVAKSLGSWGETIDESNADSARKILDEALAVCRSGEQSALVNVLIGKTDFREGSISV
What is the function of this protein?
Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner.
What are the official names of this protein?
2-hydroxyacyl-CoA lyase 2, IlvB-like protein.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: HIS6_VIBPA
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVARVAEVIDIPFCVAGGIKSAEDAARILEFGADKVSINSPALANPQLITDLADKFGVQCIVVGIDSYYDKDTGKYQVYQFTGDEERTKATKWETRDWVQEVQKRGAGEIVLNMMNQDGVRSGYDIEQLNMVREVCKVPLIASGGAGAMEHFAEAYQKANVDGALAASVFHKQVINIGELKQYLKQQGIEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RME6_DROME
Sequence: MEPPAAGNLLEIMDLARTLRQEQLFIQQEQAAFAQLTGAFESNAGTITKLAFVCAQQRQILNELLLARTDQDPLLFCRRASAYDSAQFVDAKQLLPYEHALAYEDLFNYLYNTPYLLALSLATADRLSLLSASQLGQIINTIATGLYGNAINTKDVELLLKLLRELIEIQLLTSEQPRRLLRTNSSSFARLYQRLVESLFSARIFLTAALHAPLMGVLSEHEIWLDLDPHKLMQTFTPKEREKRFGREGDEEYQRNVARFHAETLGKLHSHVQEFVKSLQQSWALFPSSLRWLLQTLSQQLRQSLRHEEQEIRQLLTDLVFTHFISPAIASADLLGIIDVNVSERMRHNLNQIVKLLQRLALNDEDSELVQLMELLMLGQTGEDVVAILPQQSDFERSQLAINQRELAQLVEFFRLLTARDEYDISVEERQRLQRILGRIPKQQVQQQQQTPKDAPDSRESPEKSKKSNKSLMSLGKAKKKLAKGMSFSSGSSNHNPVPVSEPLTNGQANTSNGSGGLGADLEHCSSHSGSNTSLSSCGANMPTTNDPLDMSTSSDPVLVFSLYNAGAKSKLKPLTEEEVLKMNSIGQDGSNLLPAVVTTAPLAPSSNNDDVSSLEAMRRPQDDASIGNSDNLEAISEAAHSVASSLDLEEQQERDVHENEDNLSDMVSANVSGRGTPNISGRDTPSSQVTDGDGAGGDLGHHHGVHARAAANPQMQKMLLSKARSDIEDKFCKFELKKFEGDENVSIISDTWSTDVLASDSENTLDATVSERGDRDRNFSTPLIPSAVVLPGDNNFVVEALARAGRVSGVHGPQLDASDQRSESNWSTDVLASDSEKLAEIDTDDNVSITTKSDTTAPQAAVLDDDDEDEQTPGSSGDGEPDPDRGNGSERSQEDSAFFDAVNSYEDANLYHGASSLARSSVRTSYHVLGGESSFQQQYKCSGADSSGRKTTPLMGTSCMRRQTSAESSISNQSLNLEEPPPPMGKHHHHHREHHHRDYHHHHRERERERERERSALKKKKHQQQEKEHRDLIDFSDCSEDKEELARNRDEEQPPGLVQQLLDMINQDEQTGAVSSSSPNVEHRRISIEQRSAIIDGRRNGILAGSMRRHQSLNYENHEIMLNSMLPKTDDDKQEMLLCVQTQQLQLEERRGSAGLRPEVDGASGIAAAGGSGLKPPTKATGAIPKSISFDASADKDKQTYHRDGERDRERDRERERDRERDRERDRERDRERDHHGAGIFNKLRQGIFKNRRGASAKNASNSSNQSNPAASTSSVQADIRSVSFDPSAGCDNFGTHYCDTSEDILAKYRRKVSSSSEATNSDSTGNGHGVGSTGSVGAAAHLHKHMNGGHIPGVVFGCVKQKLRTVLSRTDLHSGDFRQTSTTSTTMATPLQIYLQIQLAQCISLQRLPQISHVAEALRCLAQLERPQHGQLLAELQRDLERRQSYLQYLMRHRQQLLLRSEQLEQLEARLRGEARSSQRCLLQALVRMYLAWSRQQEKLEQFQAEFAQLRASDERVELTEEFVESLLQELRSSADLQDEWQVDAARVAIERMLLEQMYEQVMFPNEDADVSRDEVLSAHIGKLQRFVHPAHPALCIAQEYLGEAPWTFAQQQLCHMAAYKTPREKLQCIINCISSIMSLLRMSSGRVPAADDLLPVLIYVVIMANPPYLLSTVEYISCFLGKKLEGEDEFYWTLFGSVVKFIKTMDYLD
What is the function of this protein?
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis.
What are the official names of this protein?
Receptor-mediated endocytosis protein 6 homolog.
What is the protein family that this protein belongs to?
Belongs to the GAPVD1 family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: DNLJ_MYCBT
Sequence: MSSPDADQTAPEVLRQWQALAEEVREHQFRYYVRDAPIISDAEFDELLRRLEALEEQHPELRTPDSPTQLVGGAGFATDFEPVDHLERMLSLDNAFTADELAAWAGRIHAEVGDAAHYLCELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNARTIADVPERLTPGDDYPVPEVLEVRGEVFFRLDDFQALNASLVEEGKAPFANPRNSAAGSLRQKDPAVTARRRLRMICHGLGHVEGFRPATLHQAYLALRAWGLPVSEHTTLATDLAGVRERIDYWGEHRHEVDHEIDGVVVKVDEVALQRRLGSTSRAPRWAIAYKYPPEEAQTKLLDIRVNVGRTGRITPFAFMTPVKVAGSTVGQATLHNASEIKRKGVLIGDTVVIRKAGDVIPEVLGPVVELRDGSEREFIMPTTCPECGSPLAPEKEGDADIRCPNARGCPGQLRERVFHVASRNGLDIEVLGYEAGVALLQAKVIADEGELFALTERDLLRTDLFRTKAGELSANGKRLLVNLDKAKAAPLWRVLVALSIRHVGPTAARALATEFGSLDAIAAASTDQLAAVEGVGPTIAAAVTEWFAVDWHREIVDKWRAAGVRMVDERDESVPRTLAGLTIVVTGSLTGFSRDDAKEAIVARGGKAAGSVSKKTNYVVAGDSPGSKYDKAVELGVPILDEDGFRRLLADGPASRT
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RNPA_MYCA9
Sequence: MLPTRHRMTKSSEFRQTVKRGVRTTHADLVIHLRRGCPDSACEQVEGPKVGLIVGKSVGGAVVRHRVSRRLRHAAAELLPKLEPVDRMVIRALPSSSTALSASLRQQLRDGIDRSARRQEPAAERQR
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: SYFA_VIBCM
Sequence: MQHLQEIIANATSAINAAESLVALDEVRVQYLGKKGELTVQLQSLGKLPPEERRTAGQEINVAKEAVQKALAERKDALQSAELEAKLAAETIDVTLPGRRIENGGLHPVTRTIERIESFFGELGFTVESGPEIEDDFHNFDALNIAADHPARTDHDTFFFNPKLMLRTHTSGVQIRTLEERQPPLRFIAPGRVYRNDYDQTHTPMFHQVEGMLVDENVNFAQLKGILHDFLCNFFEEDLEVRFRPSYFPFTEPSAEVDVKGKNGKWLEVLGCGMVHPNVLRSVGIDPEKYSGFAFGMGVERLTMLRYGVNDLRAFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURQ_MANSM
Sequence: MTEQNLLSSLAHMISEQRNPNSMNLDSLSPLELVTLINNEDKQVPLAIEKVLPQIAQAVEKIVRTFQQGGRLVYIGAGTSGRLGVLDASECPPTYGVKPEMVVGLIAGGERALRHPIEGAEDNAEQGKADLQQINFSKKDILVGIAASGRTPYVIGALNYAKSLGAITISIASNPDSAMASIADIAIDTLVGAEVLTGSSRMKSGTAQKLVLNMLTTASMVLMGKCYQNLMVDVQASNEKLRARAIRIVMQATDCEKEVAERFLKAADNNAKLAIMMVLTNLDKQQASVLLQRHQGKLSRALSQ
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.  Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.