PharMolix/UniProtQA huggingface dataset:
Protein: TRMB_STAA9
Sequence: MRVRYKPWAEDYLKDHPELVDMEGQHAGKMTEWFDKTQPIHIEIGSGMGQFITTLAAQNPHINYISMEREKSIVYKVLDKVKEMGLTNLKIICNDAIELNEYFKDGEVSRIYLNFSDPWPKNRHAKRRLTYHTFLALYQQILNDEGDLHFKTDNRGLFAYSLESMSQFGMYFTKINLNLHQEDDGSNILTEYEKKFSDKGSRIYRMEAKFHSQK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RNH_NITWN
Sequence: MNSPALPHVTIFTDGACSGNPGPGGWGAILRFGDIEKELKGGEPHTTNNRMELLAAISALEALKRPALVDLTTDSQYVRQGITAWIHGWKRNGWRTADRKPVKNVDLWQRLDAALQPHQVRWHWIKGHDGHSENERADQLAREGVAMAKLMRTV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_THEM4
Sequence: MIINESYLNVADNSGAKLLRVIRVMGGSRRKWGTVGDIVVCSVRDAVPNGDLKKGDVVKAVIVRTKKEIRRPDGSYIRFDDNAAVVLDKYNEPKGTRVFGPVAKELREKGFMKIVSLAPEVF
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RIMM_CLAM3
Sequence: MWWTPIPEDIVRDPAAFRVGRLTKAHGLKGAVKLELFTDDPDKRFVPGAEFSLQVPESSPWHGRTLTLTELRWYNSHPVGFFDGVADRTAAESLAKAILWMTPPADEAAEPDAWYDHQLVGLTVLRDGVEVGTVSLVDHFPAQDLLHVDTPSGTVLVPFVQAIVPSVDVEAGTLVVTPPLGLFEEIPDETPTAEPTPAEAAEPAPEGDDAR
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCCA_MYXXA
Sequence: PKIRKVLVANRGEIAIRVMRTXKELGIATV
What is the function of this protein?
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), the enzyme catalyzing the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:9683657).  Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity).  Propionyl-CoA carboxylase also carboxylates acetyl-CoA, butyryl-CoA and succinyl-CoA (PubMed:9683657).
What are the official names of this protein?
Propionyl-CoA carboxylase alpha chain, PCCase, Propanoyl-CoA:carbon dioxide ligase.
Protein: PGH1_CANLF
Sequence: MSRGSRLHRWPLLLLLLLLLPPPPVLPAEARTPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTHGRWFWEFINATFIRDMLMRLVLTARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDCPTPMGTKGKKQLPDAQLLGRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLTHYGIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVERPSTEL
What is the function of this protein?
Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response.  The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes.  This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins.  The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons.  Involved in the constitutive production of prostanoids in particular in the stomach and platelets.  In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection.  In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.  Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products.
What are the official names of this protein?
Prostaglandin G/H synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1.
What is the protein family that this protein belongs to?
Belongs to the prostaglandin G/H synthase family.
What are the subcellular locations of this protein?
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: SURA_CHRSD
Sequence: MRLRSFAFLGFMLLVAMAPSMASAQPQPLDRIVAVVNKDAIMQSRLEDRVTQVRRQMASRNVPAPNEADLRRQVLDRMILEQIQLQMAERANLSIDDTQLNATVRGIAEDNGMSMDEFADALEEDGMSLASMREQVRREMLLRQVQQSQVASRVNVTDREVERYLDQQGETADTAYHLAHILVSVPESPTPEQVEQAQAKVRDLYRQLQNGANFAQLATAESDGQQALSGGDLGWRRGDQLPSLFADVVPTLSNGEVSEPIRSPSGFHLVKLIDTRGQQGEQKRVVTENRVRHILIGTNPNRNDQQAEALARDIRQRIANGESFAALAQEYSDDDGSALDGGELGWTRPGQMVPAFEDAVKALDVGELSQPVRSRFGYHVIELEDRRRQDVTRDAQREQIRQTLFQRKVSDEMEAWTQEIRSGAYIDNRLEDGRQ
What is the function of this protein?
Chaperone involved in the correct folding and assembly of outer membrane proteins.  Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins.  May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
What are the official names of this protein?
Chaperone SurA, Peptidyl-prolyl cis-trans isomerase SurA, PPIase SurA, Rotamase SurA.
What are the subcellular locations of this protein?
Periplasm. Note=Is capable of associating with the outer membrane.
Protein: AROB_BACC7
Sequence: MENIHIQTKSKEYDVHVGKESLSHLTTIVQNMQPSVSNIMIISDEAVAPLHLQTVVDALQIDQKVFSFVVPSGEKEKSFENFYAAHTSALENKLDRNSLIIALGGGMIGDLAGFVAASFMRGIRFVQVPTTLLAHDSAVGGKVAINHPLGKNMIGAFHQPEAVVYHTPFLQSLPEKEWRSGYAEVIKHALIGDVKLYHWLKEEVQTLADLRDEKLIHILTKAIPVKANIVAQDETEKGVRAHLNFGHTLGHALEKELGYGNITHGDGVAVGMLFAIFLSEQVYKVNLAYEEMKQWFLKYGYPKMPSDLSVERLVGLMKQDKKANAGTIHMVLMQEYGVVNVVSIPDETVHIALEAFQKDMGIRSR
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OAR_DROME
Sequence: MPSADQILFVNVTTTVAAAALTAAAAVSTTKSGSGNAARGYTDSDDDAGMGTEAVANISGSLVEGLTTVTAALSTAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGLN
What is the function of this protein?
Receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  The rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine.  For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine.  Tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator.
What are the official names of this protein?
Tyramine/octopamine receptor, Tyr/Oct-Dro.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRP4_THEVO
Sequence: MYQLGDVKKIVLPGDPVEVQGKIRNGIYRGPDNKYYSEYFGTLQVSDQYVDVVPFSGQYIPRKGDKVIGKIIEVGPSTWTVDINSPYFAMLHMNDTPWRISSGDLKRYLNSGDYVYAKIMSVNEIKESWLTLKEPGLKKLEGGHMVLIHASRVPRVIGKGGGMVNMVKELTSTRIIIGQNGLIWIDGPIEGVTMAIAAIEMIEREAHTEGLTVRVESFLKELRGDKDGNQQDKANQ
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Increases the RNA binding and the efficiency of RNA degradation.  Confers strong poly(A) specificity to the exosome.
What are the official names of this protein?
Exosome complex component Rrp4.
What is the protein family that this protein belongs to?
Belongs to the RRP4 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCTN_YERPS
Sequence: MLSLDQIPHHIRHGIVGSRLIQIRGRVTQVTGTLLKAVVPGVRIGELCYLRNPDNSLSLQAEVIGFAQHQALLIPLGEMYGISSNTEVSPTGTMHQVGVGEHLLGQVLDGLGQPFDGGHLPEPAAWYPVYQDAPAPMSRKLITTPLSLGIRVIDGLLTCGEGQRMGIFAAAGGGKSTLLASLIRSAEVDVTVLALIGERGREVREFIESDLGEEGLRKAVLVVATSDRPSMERAKAGFVATSIAEYFRDQGKRVLLLMDSVTRFARAQREIGLAAGEPPTRRGYPPSVFAALPRLMERAGQSSKGSITALYTVLVEGDDMTEPVADETRSILDGHIILSRKLAAANHYPAIDVLRSASRVMNQIVSKEHKTWAGDLRRLLAKYEEVELLLQIGEYQKGQDKEADQAIERMGAIRGWLCQGTHELSHFNETLNLLETLTQ
What is the function of this protein?
ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (By similarity).  Acts as a molecular motor to provide the energy that is required for the export of proteins (By similarity).  Required for type III secretion apparatus (T3SA) formation, proper protein secretion, host cell invasion and virulence (By similarity).  May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (By similarity).
What are the official names of this protein?
Type 3 secretion system ATPase, T3SS ATPase, Yop proteins secretion ATPase.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRIO_FELCA
Sequence: MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRRASAILFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: RL18_STAAW
Sequence: MISKIDKNKVRLKRHARVRTNLSGTAEKPRLNVYRSNKHIYAQIIDDNKGVTLAQASSKDSDIATTATKVELATKVGEAIAKKAADKGIKEIVFDRGGYLYHGRVKALAEAARESGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ATPG_RHOOB
Sequence: MASILELRSRIKSVNSTKKITKAQELIATSRITKAQSRVAAAKPYAEEITKVLSELASASASLDHPLLNERTDPKRAAVLVVTSDRGMCGGYNSNVLKEAEELFQLLRSEGKDPVIYVLGSKGLGYYTFRDRDLGGAWTGFSQDPGYSDAAKASRHLVDLFMAGSGSEVPAPNGEGTIEGVDELHIVYTRFVSMLTQSPEVRRMAPLEVMVSEEHVELGEDMLSNGHGSSNSEPVAGYNFEPEPDKLLGALLPKYISTRIYSSLLDAAASESAARRTAMKAATDNANELVNTLSRQANQARQAQITQEISEIVGGANALASSAGSD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RS14Z_HALMA
Sequence: MSESETTDEPDSETASSERTGQLESCQRCGREQGLVGKYDIWLCRQCFREISRGMGFRKYS
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14 type Z, HmaS14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: ADHX_RABIT
Sequence: MANKVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIFATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTNLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAALNTAKVEPGSTCAVFGLGGVGLAAIMGCKAAGASRIIAVDINKDKFARAKEFGATECINPQDFSKPIQEVLVEKTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAGAGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKINVDEFVTNTLSFDQINEAFELMHSGKSIRTVVKI
What is the function of this protein?
Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.  Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate.  Class-III ADH is remarkably ineffective in oxidizing ethanol.  Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
What are the official names of this protein?
Alcohol dehydrogenase class-3, Alcohol dehydrogenase 5, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH, S-(hydroxymethyl)glutathione dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_DEIGD
Sequence: MSKVRIYTLAKDLGVDNAKMLEILDGLGVAYKSVSSTIEEDTVELIKQILEEEGHTASAEPAPAQASGSPASPAQTEAQEAPQPTATATAEREPAAPPARELPHRAPVVTIMGHVDHGKTSLLDYIRKTKVAAKEAGGITQHVGAFEAKTSKGKIVFIDTPGHEAFTTIRARGANVADIAVIVIAADDSLMPQTREAIAHAQAAKVPMIVAINKVDLPQADPEKVKTDLTQLNLVPEEYGGDLIVVPVSAKTGEGVEDLLEYISLTAELEDLRADPQGEFSGVIIESRVDRQAGVLATVMVQEGTLHVGDFLVVGENYGKVKAMTDSNGGRIKEAGPSTPVQVLGFSEAPSSGEKVVSVKNEHAARELVAQRVETRREAENARVQRKKTLEEMMGPLGETRTVNLILRADTQGSLEAIQGILARKETEDVKLNVMLAGIGSPTEGDVLLASTADATILCFNVTASGSVKKAAEQRDIELKSFRIIYELIDEVDRLIKGNVEPVFEERPLGRAEVRMVIRHPKSGNIAGSYVTDGLLRRNAKARVLRGKQVVYEGTIVGLKRFKDDVREVQAGYECGVNLDWNDVQEGDIIEASELVEVAQA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URIC_DROPS
Sequence: MFATPLRQPTNASGARPAVSMDGQETPFQYEITDHGYGKDAVKVLHVSRKGPVHTIQEFEVGTHLKLYSKKDYYQGNNSDIVATDSQKNTVYLLAKKYGIESPEKFALMLGQHFLNKYSHVEEAHVHVETYPWQRVCQEETKSVNNQGQGSCNNFTSIDNRSLHNHAFIFTPTALHYCDVVIRRTDPKQTVITGIKGLRVLKTTQSSFVNFVNDEFRSLPDQYDRIFSTVVDCSWEYSDTETVNFSRAWQTVKNIILRNFAGDPQVGVSSPSVQHTLYLSEKQVLDVIPQVSVISMTMPNKHYFNFDTKPFQKIVPGDNNEVFIPVDKPHGTIYAQLARKNISSHL
What is the function of this protein?
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
What are the official names of this protein?
Uricase, Urate oxidase.
What is the protein family that this protein belongs to?
Belongs to the uricase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: TMC1_HUMAN
Sequence: MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKERRRRLKRGAEEEEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALENKMRNKKMAAARAAAAAGRQ
What is the function of this protein?
Probable ion channel required for the normal function of cochlear hair cells.
What are the official names of this protein?
Transmembrane channel-like protein 1, Transmembrane cochlear-expressed protein 1.
What is the protein family that this protein belongs to?
Belongs to the TMC family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localized to the stereocilia of the cochlear hair cells.
Protein: VF108_ASFK5
Sequence: MVNLFPVFTLIVIITILITTRELSTTMLIVSLVTDYIIINTQYTEQHEMNKFSAQQGLQKNSFDESYNKDKKPNTHISYQWLAPELKEAENKYWWGNDDPYSQPVLAGAS
What are the official names of this protein?
Inner membrane protein H108R, pH108R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus H108R family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Note=Probably part of the inner envelope.
Protein: HAOX2_ARATH
Sequence: MDQIVNVDEFQELAKQALPKMYYDFYNGGAEDQHTLNENVQAFRRIMFRPRVLVDVSKIDMSTKILGYPISAPIMIAPTGNHKLAHPEGETATAKAAAACNTIMIVSYMSSCTFEEIASSCNAVRFLQIYVYKRRDITAQVVKRAEKAGFKAIVLTVDVPRLGRREADIKNKMISPQLKNFEGLFSTEVRPSKGSGVQAFASRAFDASFSWKDIEWLRSITELPILVKGILTREDALKAVEAGVDGIIVSNHGGRQLDYSPATITVLEEVVQVVRGRIPVLLDGGVRRGTDVFKALALGAQAVLIGRPIIYGLAAKGEDGVKKVIDMLKNEFEITMALSGCPTIDDITRNHVRTENERLHSML
What is the function of this protein?
Oxidase that catalyzes the oxidation of a broad range of 2-hydroxyacids to the corresponding 2-oxoacids, with a reduction of O2 to H2O2.  Displays the highest activity with leucic acid (2-hydroxy-4-methylpentanoate) and has intermediate activity with 2-hydroxyhexanoate and 2-hydroxyoctanote.  Shows lower activity with 2-hydroxydodecanoate, valic acid, and isoleucic acid and extremely low activity with glycolate and L-lactate.  Cannot use 2-hydroxyhexadecanoate or D-lactate as substrates.  May be involved in the conversion or degradation of 2-hydroxyacids produced during the metabolism of fatty acids or amino acids.
What are the official names of this protein?
Peroxisomal (S)-2-hydroxyacid oxidase GLO3, Glycolate oxidase 3, AtGLO3, GOX 3, Short chain alpha-hydroxy acid oxidase GLO3, lHAOX2.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: CBR2_PIG
Sequence: MQMNFSGLRALVTGAGKGIGRDTVKALHVSGARVVAVTRTNGDLVSLSQECPGIEPVCVDLGDWEATERALGGVGPVDLLVNNAAVALMQPFLDTTKEVFDRSFNVNLRSVFQVSQIVARSMIERGVPGSIVNVSSMVSHVTYPGLAAYSSTKGAMTMLTKSMAMELGPHKIRVNSVNPTVVLTAMGRSVTSDPELARKLKERHPMRKFAEVEDVVNSILFLLSDRSASTSGSSIFVDAGYLAS
What is the function of this protein?
May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism.
What are the official names of this protein?
Carbonyl reductase [NADPH] 2, Lung carbonyl reductase, LCR, NADPH-dependent carbonyl reductase 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: AZOR_SHISS
Sequence: MSKVLVLKSSILAGYSQSNQLSDYFVEQWREKHSADEITVRDLAANPIPVLDGELVGALRPSDAPLTPRQQEALALSDELIAELKAHDVIVIAAPMYNFNISTQLKNYFDLVARAGVTFRYTENGPEGLVTGKKAIVITSRGGIHKDGPTDLVTPYLSTFLGFIGITDVKFVFAEGIAYGPEMAAKAQSDAKAAIDSIVAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: SRA23_CAEEL
Sequence: MNKTAEELLDSLKCASDGLASALTSVTLKFNCAFISTIVLISYCFSWLAIQALWNNNIFSNSTRLILIVCLLNSVVHQTTVMETRITQIYRSIVFASEPCEILFRSSECEIELYFYYLTNYFSTYSVFSLTFDRLISHYKSKYYHMHQYFIAISLLVLQFLLAILSFYIAYHGVPLAGYVPMCNYYPKMAVHHITINDVRTVVMVSCIIVTGFAYYLSVKSEKQIQKCSYSPGERYSAYENVTTSQSVCILIVLQFSCTMISSFGVNLLLMMQEAVSEETFTKVGAFLPGVAYANLCLPLAIYFKTKLTIQNRKLRIAVMISMYGDVGEHIARLKKSWEY
What are the official names of this protein?
Serpentine receptor class alpha-23, Protein sra-23.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein sra family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.