PharMolix/UniProtQA huggingface dataset:
Protein: Y086_MYCPN
Sequence: MESALNQEFQIDFCVKNKKLLKILANVLIASWLSFVVFLILGCIAIDLFRFDLYSQFFFNHLSTLSALAWTFFVLAILFGAATLAINGFFYKEIRKKSAFKEDSK
What are the official names of this protein?
Uncharacterized protein MPN_086.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX7C_HUMAN
Sequence: MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQLLKT
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7C, mitochondrial, Cytochrome c oxidase polypeptide VIIc.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIc family.
Protein: GLSA_SALCH
Sequence: MAWAMDNAILETILQRVRPLIGQGKVADYIPALASVEGSKLGIAICTVDGQHYQAGDAHERFSIQSISKVLSLVVAMRHYPEEEIWQRVGKDPSGSPFNSLVQLEMEQGIPRNPFINAGALVVCDMLQGRLSAPRQRMLEVVRALCGVSDITYDATVARSEFEHSARNAAIAWLMKSFGNFHHDVPTVLQNYFHYCALKMSCMELARTFVFLANQGEAFHLDEPVVTPMQARQINALMATSGMYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDPAGNSLAGIAALEQLTQTLGRSVY
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: CYB_AEGAC
Sequence: MAPNIRKSHPLLKTINNSLIDLPTPPNISTWWNFGSLLGICLMAQIITGLLLATHYTADSTLAFTSVSHTCRNVQYGWLIRNLHANGASMFFICIYLHIGRGLYYGSYLYKETWNTGVLLLLALMATAFVGYVLPWGQMSFWGATVITNLFSAVPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFIIAALTLVHLAFLHESGSNNPLGIPSSCDKIPFHPYYTMKDILGLMFMLTPLMTLALFSPNMLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILLLMPFLHKSKQRTMTFRPLSQILFWMLIANLLILTWIGSQPVEDPFIIIGQLASITYFTLILVLLPMASTLENKLLKY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: LYSX_MYCLB
Sequence: MTTVDASPGISRFEGISSRSVTVATICSGPCSGSRSHSRYHWVPAAAGWTVGVIATLSLIASVSPLIRWLIRVPREFINNYLFNFPDTSIAWSFVLALLAAALTTRKRIAWLLLLGNMVLAAVLNAVDMAANGNTPAETFGENLGFAVHVVAILLLVLSYREFWAKVRRGALFKAAAVLVAGDVIGILLSLGLVELFPGSLARQDRLPYVANRVVGFALADPDLFSGKPHVLLNAIFGLFGALALIMATIVLFQSQRADNALTGEDESAIRGLLELYGKNDSLGYFATRRDKSVIFAHNGRAAITYRVEIGVCLASGDPVGDPGAWPQAVDAWLELCQTYGWAPGVMGASSQGAQVFRRAGFNAIELGDEAILRTAVYKLSGPDMRGVRQAVTRARRAGLTVRIRRHSDISANEMADTIARADAWRDTEFERGFSMALGRLGDPADSDCLLVEAVDRDDHVVAILSLVPWGTTGVSLDVMRRSPQSPNGTIELMVSELALKGETLGIARISLNFTMFRAAFEQGAQLGAGPIARLWRGLLLFFSRWWQLETLYRSNIKYLPDWVPRYACYEDARLIPRVGVASVIAEGFLVLPFSRRGRVHTGHHPAVPARLAESGLLHHDGSTPDVSGLQTADVDLEVANSRIPEQVRVRLAKLKTLQLNGIDAYPVGHPPSHTVAQALDADDEGTVSISGRILRIRDYGGVLFAHVRDWSGEIQVLLDNLVLECCCIADFTAAIDLGDIVEMTGNMGFSKNGTRSLIVRNWRLIGKCLRPLPNKWKGLTDPEARVRTRYVDLAVNTESRNLIMARSCVLRSVREMLFAKGFVEVETPILQQIHGGATARPFATRINTYDMDLFLRIAPELYLKRLCIGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLMWIDGCRELIQNAAEAANGTQTLMRPRIEGASGTANHLEPIDISGVWPVKTVYEAVSEALGECVDTSTELATLRKLSDAAHIPYWPHWDTGAVVLKLYEHLVENRTDQPTFYIDFPTSVSPLTRPHRSKPGVAERWDLVAWGIELGTAYSELTDPVEQRRRLHEQSLLAVGGNPEAMELDEDFLQAMEYAMPPTGGLGMGIDRLVMLITGRSIRETLPFPLAKPH
What is the function of this protein?
Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge.  LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M. tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins).  In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides (By similarity).
What are the official names of this protein?
Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RK23_PORPU
Sequence: MRYLKYKRYIMDSIDSRDLLDLVKYPIITDKTTKLLEENQYCFAVDPNATKINIKAAIQYIFNVQVTGVNTCHPPKKKRSIGRFIGKRPHYKKAIITLASKDSINLFPET
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AT2A_CHIOP
Sequence: YGPNELPAEEGKNAESAIEALKEYEPEMGKEIVPGDLVEISVGDKIPADLRIDQSILTGESVSVIKNILFSGTNVAAGKTQMAETEEIKTPLQQKVGEATETALIVLGEKEFTLEFSRVIVITGDNKKAEIGIAMGSGTAVAK
What is the function of this protein?
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.  Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen.  Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
What are the official names of this protein?
Sarcoplasmic/endoplasmic reticulum calcium ATPase, SERCA.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RL31B_LIMRJ
Sequence: MKQGIHPDYHPVVFEDSSTGYKFLSGSTATSSETVKWEDGNEYPLIRVEVTSDSHPFYTGKQKFTQADGAVDKFNKKYGLK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: RL19_SHESM
Sequence: MNNIIKMLNDEQMKQDVPAFGAGDTVVVQVRVKEGDKERLQAFEGVVIAKRNRGLHSAFTVRKISNGEGVERAFQTHSPLIASIEVKRRGRVRRAKLYYLRDRSGKSARIREKLATK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: TM2A_METMA
Sequence: AEKLEPVLPLIV
What is the function of this protein?
This enzyme complex catalyzes an intermediate step in methanogenesis, the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and N5-methyl-tetrahydromethanopterin.
What are the official names of this protein?
Alternative tetrahydromethanopterin S-methyltransferase 28 kDa subunit, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase 28 kDa subunit.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NDK_NEIMF
Sequence: MAIERTISIIKPDAVGKNVIGKIYSRFEENGLKIVAAKMKQLTLKEAQEFYAVHKDRPFYAGLVEFMTGGPVMIQVLEGENAVLKNRELMGATNPSEAAEGTIRADFATSVSINAVHGSDSVENAALEIAYFFSQTEICPR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_FRAP2
Sequence: MDKKTARLSRSKRTRIKLKELGHTRLCVYRTPRHVYAQVISGDGSTVLAAASTVEKDVKAKCKYTGNVNSAAIVGEVIANRCKEKGISQVAFDRSGYKYHGRVKALAEAAREHGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ATRN_RAT
Sequence: MVAAAAAAEATEARLRGYTTATAAPAGWKERQHRPCAATGAWRPWPRAGLCLPRVLSRALSPPPLLPLLPLLFSLLLLPLPREAEAAAVAAAVSGSAAAEAKECDRPCVNGGRCNPGTGQCVCPTGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNKIMRLRFNHFATECSWDHLYVYDGDSIYAPLIAAFSGLIVPERDGNETAPEVTVTSGYALLHFFSDAAYNLTGFNITYNFDMCPNNCSGRGECKSSNSSSTVECECSENWKGESCDIPHCTDNCGFPHRGICNASDTRGCSCFPHWQGPGCSIPVPANQSFWTREEYSDLKLPRASHKAVVNGNIMWVVGGYMFNHSDYSMVLAYDLASREWLSLNHSVNSVVVRYGHSLALHKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKDQYAVVGHSAHIVTLSSGRVVMLVIFGHCPLYGYISVVQEYDLEKNTWSILQTQGALVQGGYGHSSVYDHRTKALYVHGGYKAFSANKYRLADDLYRYHVDTQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPELHHDVNRFGHSAVLHNSTMYVFGGFNSLLLSDVLVFTSEQCDAHRSEAACVAAGPGIRCLWDTQSSRCTSWELATEEQAEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDCHWCNDHCVPVNHSCTEGQISIAKYDNCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNSCLKITTAKENYDNAKLSCRNHNAFLASLTSQKKVEFVLKQLRLMQSSQSTSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGECTSSSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMSSCPPENCSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSHASTGNVYPQPLLNSSMCLEDSRYNWSFIHCPACQCNGHSKCINQSICEKCEDLTTGKHCETCISGFYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGEECQLCEVENRYQGNPLKGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWATSFPAGTQTGEEVPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFVYVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDLIGGSIKTVPKPIALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI
What is the function of this protein?
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity).  May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color.  Low-affinity receptor for agouti (By similarity).  Has a critical role in normal myelination in the central nervous system.
What are the official names of this protein?
Attractin, Protein zitter.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: MP2K5_RAT
Sequence: MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP
What is the function of this protein?
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex.  Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity).
What are the official names of this protein?
Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MAPK/ERK kinase 5, MEK 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
What are the subcellular locations of this protein?
[Isoform Beta]: Cytoplasm, cytosol. SUBCELLULAR LOCATION: [Isoform Alpha-1]: Membrane. Note=The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization. SUBCELLULAR LOCATION: [Isoform Alpha-2]: Membrane. Note=The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.
Protein: RP54_VIBAN
Sequence: MKPSLQLKLGQQLAMTPQLQQAIRLLQLSTLELQQEIQEALESNPLLDVEEAYEENATADVHSINEEKEASAEVLDIEPQDSSDLIEKSEISSELEIDTTWDDVYSANTGSTGIALDDDMPVYQGETTQTLQDYLLWQLDLTPFSDTDRSIALALIDAIDDYGYLTVSLDDILESFADENIELDEIEAVRKRVQQFDPLGVASVNLQDCLLLQLATYPASTPWLEEAKQLLIQHIDLLGNRDYKLIIKETKLKEEDLREVLQLIQQLDPRPGNNISTEHAEYVVPDVSVYKDHGKWVVTINPDSVPKLKINQQYAALGKGNSADSNYIRSNLQEAKWLIKSLESRNETLLKVAKCIVEHQRDFFEYGEEAMKPMVLNDVALAVEMHESTISRVTTQKYMHTPRGIFELKYFFSSHVSTDSGGECSSTAIRALIKKLVAAENTAKPLSDSKIADLLADQGIQVARRTIAKYRESLGIAPSSQRKRLL
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
RNA polymerase sigma-54 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: OPP24_HAEIF
Sequence: MKKTLAALIVGAFAASAANAAVVYNNEGTNVELGGRLSIITEQSNSTVDDQEQQHGALRNAGSRFHIKATHNFGDGFYAQGYLETRLVSDYPGSSSDHFGGITTKYAYVTLGNKAFGEVKLGRAKTIADGITSAEDKEYGVLNNKKYILTNGNTVGYTYKGIDGLDGLVLGANYLLAQSRVPGGPGLFPRKQGEVYPQQISNGVQVGAKYDANNIIAGIAFGRTNYKTAGADFDFSDAFGLGRKEQVEGVLSTLGYRFSDLGLLVSLDSGYAKTKYHTTTTDSDDGRQTITNPAYDEKRSFVSPGFQYELMEDTNVYGNFKYERTSVNQGKNTREQAVLFGVDHKLHKQVLTYIEGAYARTKTNDKGKTEKTGKEKSVGVGLRVYF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Outer membrane protein P2, OMP P2.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: ILVD_ARTS2
Sequence: MSEDTQTATENKPDIKPRSRVVTDGIHAAPARGMFRAVGMGDDDFAKPQIGVASSWNEITPCNLSLNRLAQGAKEGVHAGGGFPMQFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERIDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSIMPGWVKLEDGSEKEVTLIDAFEAVGACAAGKMSRGDLDRIERAICPGEGACGGMYTANTMACIGEALGMSLPGSAAPPSADRRRDEFARKSGEAVVNLLRLGITARDIMTKKAFENAIAVTMAFGGSTNAVLHLLAIAREAEVELTLDDFNRIGDKIPHLGDLKPFGRYVMTDVDKIGGVPVIMKALLDAGLLHGDCLTVTGKTLAENLASINPPDLDGKILRALDNPIHKTGGITILHGSMAPEGAVVKSAGFDADVFEGTARVFEREQGALDALDNGKINKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCIGHVAPEAVDGGPIAFVKDGDRIRVDIAARSFDLLVDEAELESRKVGWEPLPAKFTKGVLAKYAKLVHSASTGAYCG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CYF_DRANE
Sequence: MQTRNTFSWIREEITRSISVSLIIYIITRASISSAYPIFAQQNYENPREATGRIVCANCHLASKPVDIEVPQAVLPDTVFEAVVKIPYDMQLKQVLANGKKGALNVGAVLILPEGFELAPPDRISPEMKEKIGNLSFQNYRPNKKNILVIGPVPGQKYSEITFPILAPDPATNKDVHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNATAGGIISKIVRKEKGGYEITIVDPSNERQVIDIIPRGLELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFLASVVLAQIFLVLKKKQFEKVQLSEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ERA_CLOK5
Sequence: MIKSGFITIIGRPNVGKSTLLNSIMGEKLSIVSCKPQTTRNSIQTILTRDDFQLIFVDTPGIHKPKHKLGNYMVKVAESSVKDVDLILFLITPDVEVGKGDRYILEQLKKENIPVFLVVNKIDENPQEKVAQTLKNYSEIFDFAEIIPISALKQKNVKELVELMVKYMPEGPKYYPDDMITDKQEKFVVSEIIREKALRLLSKEVPHGIAVDILSMKKNSKGLYNIEATILCEKESHKGIIIGKKGAMLKKISTYAREDIEKFLDSKVYLEVWVKVKKEWRDSDRLLKELGYK
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: KGUA_SCHPO
Sequence: MTPQLSSSVASKLVTLKLKPVVVFGPSGVGKSTLLKRLLKDHGDKLGFSVSHTTRTPRAGEKDGIDYHFVTKEEFQKLVAEEKFVEWAVFSGNMYGTSIMAIQELEAVNKKAILDIDLQGVLQVKASPIDAQYVFLAPPSIEQLEVRLRGRGTENESAILQRLERARAEIEYSEKPGNFDALIVNDDVEKAYKQLEAICLSD
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
Protein: PXL2A_HUMAN
Sequence: MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHIRTEVKDFQPYFKGEIFLDEKKKFYGPQRRKMMFMGFIRLGVWYNFFRAWNGGFSGNLEGEGFILGGVFVVGSGKQGILLEHREKEFGDKVNLLSVLEAAKMIKPQTLASEKK
What is the function of this protein?
Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071).  Acts as an antioxidant (PubMed:19951071, PubMed:26438880).  Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071).  May affect bone resorption and help to maintain bone mass (PubMed:19951071).  Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
What are the official names of this protein?
Peroxiredoxin-like 2A, Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes, Protein PAMM, Redox-regulatory protein FAM213A.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=Secreted from mature adipocytes but not from preadipocytes.
Protein: 5HT1B_DIDVI
Sequence: MEQPSRLCSPPASGSLTSSQTNHSTFPNPNCSAPDLEPYQDSIALPWKVLLATFLGLITLGTTLSNAFVIATVSRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAGMIIMVWVFSVSISMPPLFWRQAKAEEVADCSVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSSSSGTSINSRAPEGPSESGSPVYVNQVKVKVSDALLEKKKLMAARERKATRTLGIILGAFIVCWLPFFIISLALPICDDACWFHLAIFDFFNWLGYLNSLINPIIYTKSNDDFKQAFQKLMRFRRTS
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various alkaloids and psychoactive substances.  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.  Signaling inhibits adenylate cyclase activity.  Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior.  Besides, plays a role in vasoconstriction of cerebral arteries.
What are the official names of this protein?
5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B, Serotonin receptor 1B.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KAD8_HUMAN
Sequence: MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP
What is the function of this protein?
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.  Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP.  Also displays broad nucleoside diphosphate kinase activity.
What are the official names of this protein?
Adenylate kinase 8, AK 8, ATP-AMP transphosphorylase 8.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, cilium axoneme. Note=Located in the proximal region of respiratory cilia.
Protein: RRP36_YEAST
Sequence: MSYYFKNLKPDLNSDVEEDDGNLLESIMANKSKREIDEQESSDDELKTLSFGSLKKAETVIDEEDFKDTKPVHKKPITTTYREESFDEDEDSEDQSDEDAGFFEEDSEDETHHGQKVPKKKSKHAPVEQSSKKRVPRVRNIPGLEIPRNKRSNLYQDIRFDKSTGKALDSSIIRKRYQFLDEYREKEIDELQKLLQERKFLSKIDQGEREEMEQRLKSMKSRLQSMKNKDLEREILKEYENDMNKNNNTRYHLKKSEKRKVVQKWKFDHMKAKQREKVMERKRKKRLGKEFKQFEFHNRR
What is the function of this protein?
Component of the 90S pre-ribosome involved in the maturation of rRNAs.  Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
What are the official names of this protein?
rRNA biogenesis protein RRP36, Ribosomal RNA-processing protein 36.
What is the protein family that this protein belongs to?
Belongs to the RRP36 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.