PharMolix/UniProtQA huggingface dataset:
Protein: WASH1_BOVIN
Sequence: MTPTGTQHSLAGQTYAVPLIQPDLRREEAIQQVADALQYLQKVSGDIFSRISQRVELSRSQLQAIGERVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIFMGAQDPGLQRRPRHRIQSKHRPLDERALQEKLKFFPVCVNTKPEPEDEAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISRREQLERQVPENYFYVPDLGQVPDIDVPSYLPDLPGVADDLMYSADLGPGIAPSAPGAIPELPTFHTEVAQPFKPDLEDGVLTARPPPPPPPPPPPAPAVLMSVPPPPPPPQAPPGQPAKGDDSGGASPSAPVQGAPKEVVDPSSGRATLLESIRQAGGIGKAKLRSVKERKLEKKKQKEQEQVRATSQGGDLMSDLFNKLAMRRKGISGKGPGSGASEGPGGAFARMSDSIPPLPPPQQPPGEEDEDDWES
What is the function of this protein?
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.  Involved in endocytic trafficking of EGF.  Involved in transferrin receptor recycling.  Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration.  In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function.  In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation.  Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).
What are the official names of this protein?
WASH complex subunit 1, WAS protein family homolog 1.
What is the protein family that this protein belongs to?
Belongs to the WASH1 family.
What are the subcellular locations of this protein?
Early endosome membrane. Recycling endosome membrane. Late endosome. Cytoplasmic vesicle, autophagosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2.
Protein: PYRB_ANAMM
Sequence: MGNLKKLLRVSDLSDEDVENLLILANKYMAQEASDEVLRGKVIVNLFFESSTRTLLAFEIAEKALGAISVTLNVAMSSICKGESISDTMSTMAAMGTDLVVVRSDQSCMVDEIAKRAGDCLVINAGDGNHEHPTQAITDYATIRSLKGGEVRGLKVAICGDVFHSRVARSNIRLLSRYGADIRVVTPMRVDHVPDGVSLVTRSLEEGIEGADVIMLLRIQRERMTNGDFMLDKEYSRLYMLDEKRLSLAKDDVIVMHPGPMNRGVEISDEVADNHSSVLFQVKVGAAVRKAVLHYMLG
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: BR2B_ODOGR
Sequence: GVLGTVKNLLIGAGKSAAQSVLKTLSCKLSNDC
What is the function of this protein?
Antimicrobial peptide active against the Gram-positive bacterium S. aureus (MIC=25 uM) and against the Gram-negative bacteria E. coli (MIC=6 uM).  Has no antifungal activity against C. albicans.  Shows hemolytic activity against human erythrocytes only at high concentrations (LC(50)=180 uM).
What are the official names of this protein?
Brevinin-2GRb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: PSAA_SYNPW
Sequence: MTISPPERGSTAKTQVEKVDNPATFELFGKPGHFDRALAKGPKTTTWVWNLHANAHDFDSHTSDLEEVSRKIFSAHFGHLAVIFIWLSGAFFHGARFSNFSGWLADPTHVKPSAQVVWPVFGQEILNGDMGAGFQGIQITSGLFHVWRAWGITNETQLMSLAIGALVMAGLMLNAGVFHYHKAAPKLEWFQNVESMLNHHLAGLLGLGSLSWTGHLLHVSLPTTKLMDAIDAGQPLVLNGKTIASVADIPLPHEFFNQDLLAQLYPGFGAGIGAFFSGNWAAYSDFLTFKGGLNPVTGSMWMSDIAHHHLAIAVLFIVAGHMYRTNWGIGHSIKEILEGQKGDPLLFPATKGHDGLFEFMTTSWHAQLAVNLAMLGSLSIIVAQHMYAMPPYAYMSIDYPTQIGLFTHHMWIGGFLIVGAAAHAAIAMIRDYDPAKHVDNVLDRVLKARDALISHLNWVCIWLGFHSFGLYIHNDTMRALGRPQDMFSDSAIQLKPVFAQWIQGLHAAAAGSTAPNALAGVSEVFNGSVVAVGGKVAAAPIPLGTADFMVHHIHAFTIHVTVLILLKGVLYARNSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNSLSIVIFHFSWKMQSDVWGTVNADGSVQHITNGNFANSAITINGWLRDFLWAQAAQVINSYGSNTSAYGLMFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPAIQPRALSITQGRAVGVAHYLLGGIATTWAFFHAHILVVG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: GYRA_CHLPN
Sequence: MFNKDEIIVPKNLEEEMKESYLRYSMSVIISRALPDIRDGLKPSQRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQNWAMRYPLVDGQGNFGSIDGDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYDETKHEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLLLANPQASVDEILQVMPGPDFPTGGIICGSEGIRSTYTTGRGKIKVRARLHVEENEDKHRESIIITEMPYNVNKSRLIEQIANLVNEKTLAGISDVRDESDKDGIRVVLEIKKGESSEIIINRLYKFTDVQVTFGANMLALDKNLPRTMSIHRMISAWIRHRKEVIRRRTRYELNKAETRAHVLEGYLKALSCLDALVKTIRESGNKEHAKERIIESFGFTEPQALAILELRLYQLTGLEAEKIQKEYEELLNKIAYYKQVLSDEGLVKDIIRNELQDLLKHHKVARRTTIEFDADDIRDIEDIITNESVIITISGDDYVKRMPVKVFKEQRRGGHGVTGFDMKKGAGFLKAVYSAFTKDYLLIFTNFGQCYWLKVWQLPEGERRAKGKPIINFLEGIRPGEELAAILNIKNFDNAGFLFLATKRGVVKKVSLDAFSNPRKKGIRALEIDEGDELIAACHIVSDEEKVMLFTHLGMAVRFPHEKVRPMGRTARGVRGVSLKNEEDKVVSCQIVTENQSVLIVCDQGFGKRSLVEDFRETNRGGVGVRSILINERNGNVLGAIPVTDHDSILLMSSQGQAIRINMQDVRVMGRSTQGVRLVHLKEGDALVSMEKLSSNENDDEVLSGSEEECSDTVSLR
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_MYCMS
Sequence: MIFAQEKFVDQGQGKWTVTIQDDQWTEFLKKAKNRLKTNLVVPGFRKGKAPESETAKYLTPIKIYNEAFKIVVKPAFDFALSQENKIQNDNSPTPVIVKVSDKEIVIDFIFDLVLELKVGEYKNITTVKKPVVEVNQEDVDNVIDMYRSRFAMQKEKQADDQIQKGDIVTFDFKGYVDDQAFEGGEAKDFVLEIGSNQFVPGFEDSMIGLKVGENQEINVKFPEEYIPSLAGKDAKFVLNIKNIKEKILPAKDDELVKDLNLPDITTYEQLEQKVKEDVLEQKTKISKSEFVENIIDEIIKTSEFQIPKTIIERQIKDVKKEFEDQLAQQKITLDKYKEITKITQEEIDEELKSDAIHRIKSFLVASEIKNKENIVASEEAINAKFEEFANLYGIEADKIKSLIDNQAIKHQVESELLETFIFENNGN
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ORF5_STRGR
Sequence: MSLDVRTITPSESAEWMRAVSTGFLTAGTPSEELVADRFAGADLSRTQGAFEAGRCVATFRSFAQELTVVGGATVAADAISGVTVTPTHRRRGLLSRMMATDLAAAKERGEPVASLIAAEYPIYGRYGFGPAAWTSVWEVSVYRAGLDARRSGQPADGGRIEMVDGADVRKLGPEVHGALAARQPGVVTRDERWWRQRTGAAPSSAHEKWTEPFYVVHRAADGTVDGLMTYGTDDTWGDAKQPLNTASVRDMIALNPAAERALWHYLCSIDWITTIRSGYRAPDDLLPLLLPDPRAARMITNADWLWLRMLDVPRALEARTYGTEASLVLEVRDDAGLAGGRFLLDASTGGARCVSTTRSADLVLGVAELATLYLGDESVRRLVDLGRAEESRAGAATTADAVFRTGRRPWCPDVF
What are the official names of this protein?
Uncharacterized N-acetyltransferase ORF5.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase Eis family.
Protein: FLIPR_STAAC
Sequence: MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKESDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIKVVKNGEIDSITWY
What is the function of this protein?
May be involved in countering the first line of host defense mechanisms.  Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity).
What are the official names of this protein?
FPRL1 inhibitory protein, FLIPr.
What is the protein family that this protein belongs to?
Belongs to the CHIPS/FLIPr family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL5_PSYA2
Sequence: MARLKSLYNEELKQQIKEELGLANVMQVPKITKITLNMGVGGASQDKKLLEGAVADMTAIAGQKPVVTKARKSVAGFKIREEWPIGCKVTLRGEQMYEFLDRLVAIAIPRIRDFRGFSPKAFDGRGNYSLGIKEQIVFPEVDFDKIDRIRGMDVTITTSAQSDEEGRALLKAFGFPFK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: BLI1_YEAST
Sequence: MGEQNKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNEAWLEELENKFKLKDDVELDDVENLRAEIDMKLNMLEDKVSYYERLYKELEEFQNEIKIKTVVNNRRQSRTPK
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit BLI1, BLOC-1 subunit BLI1, BLOC-1 interactor 1.
What is the protein family that this protein belongs to?
Belongs to the BLI1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: UVRC_BORAP
Sequence: MKENLTSLFEKVIKLPTTSGCYKMLNENKKILYIGKAKNLRSRIKSYFLEKKSHKIKILMKNVKSIEVITTNSEYEALLLECNLIKTHKPDYNVKLKDGKGYPMVRITHEKYPRIFKTRKIINDQSEYFGPFTNVKKLDQVLDFINKTFKIRKCKKKSNTPCLYYHMGQCLGVCFKENLEKEYQEELDKAKSILNGNISEILSQIDIKLKLAVQKEDFENAIKLKEIKSSLIEINQIQIVTKTNNLNTDYVYVHPGENVNTIIVLKYRNGKLVERDANFDESICKKNELILQFLIQYYTSINMIVPDKIHIFLKDIDTKNAEKLINEIKNTKTEIIYKETEEILKIMEMAISNAELSLREYENKNNKALESLKIFLEMDKLPKIIEGFDIAHLKGQETVASMVTFKMGIPFKENYKLYKLNSLLKGEIDDVKAIKEVILRRYSEIINKNLELPNLILIDGGKGQLNAAFSILKGLKIENKVKVCSLAKKHETIFLTTNKKGINLPQGHPALRILQNVRDEAHRKANGFNKKRREKITLLYTKINGIGEKTAQKILKSIGTYKDILPLSENEISEKIKVNIRLAKRIKEFAIKENSIKT
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPA_RHOCS
Sequence: MTAEGLLQILLYLGLLAAVTPLLGRYMARVFEGERTLPGIVLGPLERGLYRIAGIDPAREQHWTGYTLALLSFNLLGLLLLYALLRFQALLPLNPAELGPVGPDLAFNTAVSFTTNTNWQSYGGETTLSYLSQMLGLTVQNFVSAATGIAVAVALIRGFARRAGKTVGNFWADLVRATLYVLLPLAFLGALVLVWQGVPQNFDAYVTATTLEGGNQVLAQGPAASQIAIKQLGSNGGGFFNVNSAHPYENPTALTNLLESFYLLMIAAALIYSFGRMVGDTRQGRALWTAVFILFVAGLAVTWWAEAQGNPAVTALGVETTDGNMEGKEVRYGTALSALWAVATTAASNGSVNAMHDSFMPLGGMVPMLNMMLGEVIYGGVGAGLYGLLVFVILAVFIAGLMVGRTPEYLGKKIEAREIKLAVIAVLVFPLGILGGAALTTVVPQMLASVQDPGPHGLSEILYAYTSATGNNGSAFAGFGANTPWHNTGLGLAMLLGRFAVIVPTLAIAGSLVAKRAAPAGPGTLPTHGTLFITLLIATILIVGGLTFFPALALGPIAEHLSLTAGTLFGAVP
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DLP1_ORNAN
Sequence: MRLAYLLLLLVAVLFQAGGGSVEAFVQHRPRDCESINGVCRHKDTVNCREIFLADCYNDEQKCCRK
What is the function of this protein?
Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities.
What are the official names of this protein?
Defensin-like peptide 1, DLP-1, Ornithorhynchus venom defensin-like peptide C, OvDLP-C.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1887_AZOSB
Sequence: MIFVISPAKALDYETPPVTARFTTPDFLDDAAELIDILRTCTPADIAGLMSLSDKLASLNVARYATWSRPFAPDNAKQAILAFNGDVYEGLAATTLGEDGLAWAQDHLRILSGLYGVLRPLDLMQPYRLEMGTRLSNPRGKDLYAFWGERITTELNRLLDLERAAGREAVLVNLASEEYFKSVKPKLLKGRLVTPTFEDWKDGRYKIISFYAKRARGLMSRYAIERQLDEVEDLKAFDSDGYAFVAEASDEHSWVFRRRQD
What are the official names of this protein?
UPF0246 protein azo1887.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: MATK_COFAR
Sequence: MEEIQGYLQLDRSQQHGFLYPLIFQEYIYALAHDHSLNRSILLENPVYDNKSSFLIVKRLITRIYQQNHFIIFANNSNQNLFFGHNKNLYSQTISEGLAFIVEIPFYIRLISSQGGKGILKFRNLRSIHSPFPFLENNFSHLNSVLDILIPHPVHLEILVQNLRYWVKDASSLHLLRFFFHEYWNWNTLIDRKKPSFDFSPKRNQKLFFLLYNSHVCEYESIFFFLRKQSSHLRSTSFGVFLERIYFYEKKERLVEVFAKDFQASLWLFKDPFIHYVRYQGKSILVSNGTPLLMNKWKSYLVNFWQCHFGIWFHPGRVYINQLPNYSFNFMGYLSSVRLNHSMVRSQMLENAFLINNAIKKFDTLVPLIPLIGSLAKAKFCNLLGHPISKPIWTDLADSDIIDRFWHICRNLSHYYSGSSKKKSLYRIKYILRLSCAKTLARKHKSTVRAFLKGLGSEFLEKFLTSEEEALSLTFSRTSSTFRGVYRNRIWYLDIIYINDLTNYQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CTRA_BRUO2
Sequence: MRVLLIEDDSAIAQSIELMLKSESFNVYTTDLGEEGIDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLSKVKTPILILSGMAGIEDKVRGLGFGADDYMTKPFHKDELIARIHAIVRRSKGHAQSVITTGDLVVNLDAKTVEVAGQRVHLTGKEYQMLELLSLRKGTTLTKEMFLNHLYGGMDEPELKIIDVFICKLRKKLDAVSGNQSYIETVWGRGYVLREPDAEMRESA
What is the function of this protein?
Essential protein that plays a role in the control of cell division, possibly through the transcriptional regulation of ccrM, rpoD, pleC, minC and ftsZ genes.
What are the official names of this protein?
Cell cycle response regulator CtrA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTP1_CFEPV
Sequence: MFALDSIVGKHINYALDKTQHLPNKINNSITNTEIILQDYQYFASRIFIGLKNLNSMLLFWDTGTGKTLTAVYIIKYIKELFPRWIILIFIKKSLYVDPWLNTISSYISDTSNIKFIYYDSTSSLDKFNNIYRSIESSLNKKNRLLIIIDEVHKLISRSVKKDNSERNFTPIYRKLIKLANYENNKILCMSATPITNNIAEFNNLIGLLRPNVMNIKEEYINNGKLINFKEIRETLLGICSYKRLIEADSLTDTNYIDGYAKKSIFYHNIIMSDEQSKLYNMAERYDYKTELGGLKTMRRLISSFAFYDLKIKGDLDNVEYNEMIKRKLAEFSEFTKNINFSKEFINAFKNNEIKTKTDLLITDINNYNILYQYSCKYIEACRIILNSRGKVLLFEPLVNFEGISSLKYYFNCFNISYIEYSSKTIKMRDNDLNYYNNYENNDGNKIKVCIFSYAGSEGISFKCINDIIILDMPWNESELKQIIGRSIRLNSHEYLPINYRYVNVHFIISYSNNRKSVDKEILDIIKNKQGKINVVFDLLKASPIEIIHNMYKYIEPVDNEIIFETIRKTRMKEMNISNVIINLKLYPITYCKDYDRATILKGLLNKDTNIIYDNDTPVAILLVDNNNLPIFVIENDILIYITNDYY
What is the function of this protein?
DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts.  Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex.  NPH-I must bind ssDNA in order to exhibit ATPase activity (By similarity).
What are the official names of this protein?
Nucleoside triphosphatase I, NPH-I, Nucleoside triphosphate phosphohydrolase I, NPH I.
What is the protein family that this protein belongs to?
Belongs to the helicase family. NPH I subfamily.
What are the subcellular locations of this protein?
Virion. Note=Virion core enzyme.
Protein: QUEA_BURP0
Sequence: MLTLSDFDFDLPPELIAQTALPERSASRLLEVDNTNPSAPPRLVDRRFAELPACVAPGDLLVFNDTKVLKARFFGRKASGGKIEVLIERVTGERTALAQIRASKSPPPGTTLTLADAFDVTVGERVEPFFTLHFPDDCLVLIERHGRLPLPPYIEHAPDAADETRYQTVFAANPGAVAAPTAGLHFDDAVLAALEARGVERATLTLHVGAGTFQPVRVENLAEHRMHSESYELTDALVEKIAATRARGGRVIAVGTTSMRALEAAARDAQAAGRPLAATRAETDIFITPGYRFRVVDRLVTNFHLPKSTLLMLVSAFAGIETIRAAYRHAIDARYRFFSYGDAMLLTRRDDAAEATHGGA
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNRHR_PIG
Sequence: MANSASPEQNQNHCSAINSSILLTQGNLPTLTLSGKIRVTVTFFLFLLSTAFNASFLLKLQKWTQRKEKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLAVKSNSRLGRFMIGLAWLLSSIFAGPQLYIFRMIHLADSSGQTEGFSQCVTHGSFPQWWHQAFYNFFTFSCLFIIPLLIMLICNAKIMFTLTRVLQQDPHNLQLNQSKNNIPRARLRTLKMTVAFAASFIVCWTPYYVLGIWYWFDPEMVNRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL
What is the function of this protein?
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH).  This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, Luteinizing hormone-releasing hormone receptor, LHRH.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KC1D_RAT
Sequence: MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
What is the function of this protein?
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms.  It can phosphorylate a large number of proteins.  Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2.  Central component of the circadian clock.  In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.  Controls PER1 and PER2 nuclear transport and degradation.  YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation.  DNMT1 phosphorylation reduces its DNA-binding activity.  Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation.  Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth.  Phosphorylates NEDD9/HEF1 (By similarity).  EIF6 phosphorylation promotes its nuclear export.  Triggers down-regulation of dopamine receptors in the forebrain.  Activates DCK in vitro by phosphorylation.  TOP2A phosphorylation favors DNA cleavable complex formation.  May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast.  Modulates connexin-43/GJA1 gap junction assembly by phosphorylation.  Probably involved in lymphocyte physiology.  Regulates fast synaptic transmission mediated by glutamate (By similarity).
What are the official names of this protein?
Casein kinase I isoform delta, CKI-delta, Tau-protein kinase CSNK1D.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity (By similarity).
Protein: AIM46_YEAST
Sequence: MRLISKVLVKTNCLEVGMRRAPQWYSHYSTTAGNARVNKKGSKVVPVLTGLALASIFAKKWYDDSQIKKADATSVAVDASISAFPKKMGPPQWPFSTQYELIGKGVRCVSSITFKAYGLGIYVAAEDKHLVSEVLDSKFLSQAFIDTAAPPSPENSHQDNLRAALNDPAKAPILINNLLDSGIRLMSKNTPIKAGSFKLLMDGTKKSVLKNPDSQSQDKDRLEAGFQELHDCFRSVKGLVARDDDFFIELNKDCSMNLSYYARKKDEFVILGTVKEPLIGKLLFAHYLAAVDPPSPEARKEVIDALVSLS
What are the official names of this protein?
Altered inheritance of mitochondria protein 46, mitochondrial, Found in mitochondrial proteome protein 34.
What is the protein family that this protein belongs to?
Belongs to the AIM18/AIM46 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RL30_CERS4
Sequence: MAKTIIVKQVRSAARRPAVQTAVLKGLGLNKMHRTRELEDTPSIRGMVAKIPHLVEIIEERG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RS13_METSB
Sequence: MARIAGVNIPTNKRVVIALQYIHGIGSKKAEEICAKVNIPDARRVSELTDAEVLQIRETIDRDYLVEGDLRREVAINIKRLMDLGCYRGLRHRRQLPVRGQRTHTNARTRKGKAKPIAGKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: LLPH_HUMAN
Sequence: MAKSLRSKWKRKMRAEKRKKNAPKEASRLKSILKLDGDVLMKDVQEIATVVVPKPKHCQEKMQCEVKDEKDDMKMETDIKRNKKTLLDQHGQYPIWMNQRQRKRLKAKREKRKGKSKAKAVKVAKGLAW
What is the function of this protein?
In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.
What are the official names of this protein?
Protein LLP homolog, Protein LAPS18-like.
What is the protein family that this protein belongs to?
Belongs to the learning-associated protein family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome. Note=Cell-permeable protein. 22 hours after injection in the hippocampal area CA1, internalized by most cells at the injection site (By similarity). Localizes at the chromosome periphery during mitosis (PubMed:20813266).