PharMolix/UniProtQA huggingface dataset:
Protein: Y886_METJA
Sequence: MTRYLTLHSIEEAKSIINESLKKLKNEVEEVDLFNAIGRVLAEDVFSNIDIPPYDRAKMDGYAVKAEDTYEADEDNPVELKVIGSLKAGEIKDLEINNGECVEIATGAIIPKGANAVVMVEYTERDNDRVKIYRAVPPMENIQFTGSDIMAGELVLRKNTKLTPRDIGVLAAIGKSKVKVYKKLKFGIISTGNEIISPNEQLEFGKIYDINSYTLVSYIKTLGYDFEFFGIAKDDKEELKEKIKKALKCDIILLSGGTSAGVGDLTETAIKELGGKILVHGIKIKPGKPTIIGKIDNKLIVGLPGYPTSCLTIFDVLFGDEKNVVKAKFPVRYISAKGRVEYLPVILVKHKNGFSAYPITKGSGAITSLSEADGYIIIDENKEILENEDVEVHLFGDVKVGLNIIGSHCIGVDIILKEAKLLAKTINVGSLGGVLSIKRGEADIAGIHLLDEKTNTYNIPFLEKYKVKDAVLVRGYIREQGFMFRKELGFKSIEEIIEHIYKLEFINRNKGSGTRILFDKFLKDYNINPKEIKGYNIEAKTHSAVATAIAMKKADIGLGIRTVAEQYNLAFIPLANEHYDFLIRKERFNDEDVQNFIKALKTAKLPFKKPDNCGEIIWGG
What are the official names of this protein?
Putative molybdopterin biosynthesis protein MJ0886.
What is the protein family that this protein belongs to?
Belongs to the MoeA family.
Protein: RL6_PSEPK
Sequence: MSRVAKNPVKLPSGVEVKFAGQQLSVKGAKGTLELNVHSSVEVTEESGELRFVARNGDQQARAMAGTTRALVNNMVQGVSQGFERKLQLVGVGYKAQAKGTVLNLALGFSHPVDYELPAGITAETPSQTDILIKGIDKQLVGQVAAEIRDFRPPEPYKGKGVRYADEVVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: AAPT1_ARATH
Sequence: MGYIGAHGVAALHRYKYSGVDHSYLAKYVLQPFWTRFVKVFPLWMPPNMITLMGFMFLVTSSLLGYIYSPQLDSPPPRWVHFAHGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFEAMAFGSTAMCGRDTFWFWVISAIPFYGATWEHYFTNTLILPVINGPTEGLALIFVSHFFTAIVGAEWWAQQLGQSIPLFSWVPFVNEIQTSRAVLYMMIAFAVIPTVAFNVTNVYKVVRSRNGSMVLALAMLYPFVVLLGGVLIWDYLSPINLIATYPHLVVLGTGLAFGFLVGRMILAHLCDEPKGLKTNMCMSLLYLPFALANALTARLNAGVPLVDELWVLLGYCIFTVSLYLHFATSVIHEITEALGIYCFRITRKEA
What is the function of this protein?
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively.  Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
What are the official names of this protein?
Choline/ethanolaminephosphotransferase 1, Aminoalcohol phosphotransferase 1, AtAAPT1.
What is the protein family that this protein belongs to?
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CNOT3_HUMAN
Sequence: MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQKEKYEADLKKEIKKLQRLRDQIKTWVASNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVGQWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTYPSGPPPAASALSTTPGNNGVPAPAAPPSALGPKASPAPSHNSGTPAPYAQAVAPPAPSGPSTTQPRPPSVQPSGGGGGGSGGGGSSSSSNSSAGGGAGKQNGATSYSSVVADSPAEVALSSSGGNNASSQALGPPSGPHNPPPSTSKEPSAAAPTGAGGVAPGSGNNSGGPSLLVPLPVNPPSSPTPSFSDAKAAGALLNGPPQFSTAPEIKAPEPLSSLKSMAERAAISSGIEDPVPTLHLTERDIILSSTSAPPASAQPPLQLSEVNIPLSLGVCPLGPVPLTKEQLYQQAMEEAAWHHMPHPSDSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQGTYIYFDYEKWGQRKKEGFTFEYRYLEDRDLQ
What is the function of this protein?
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.  Additional complex functions may be a consequence of its influence on mRNA expression.  May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism.  Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA.  Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases.  Involved in the maintenance of embryonic stem (ES) cell identity.
What are the official names of this protein?
CCR4-NOT transcription complex subunit 3, CCR4-associated factor 3, Leukocyte receptor cluster member 2.
What is the protein family that this protein belongs to?
Belongs to the CNOT2/3/5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body.
Protein: PYRE_CLOBJ
Sequence: MSNINVIDILKESDALLEGHFLLSSGRHSNRYCQCAKLLQCPQKAEKVISVIAEKLKEVDFNIIVGPAMGGVIVSYELARQTNKPGIFAERKEEVMCIRRGFEIKKGDKVIISEDVVTTGKSSLEVAKVIEEMGGEVVGIACIVDRRAEDIKTNYPIYSACKLEIETYEKDNCELCKKNIPFVKPGSREQK
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: YR656_MIMIV
Sequence: MIRPNMFALLMLVVLAITSVNADCPKVKRDVCVIGGGAAGMSIATLLKDRGYDPVVLERESVVGGHCNTQYFDPPEGETVDWIDYGVQLFMNTTQLNLTGVGSWSLATDKFAERFIGPNATLPLEGNDINLYVNMETGELVIPNVNETALNNALGVYFYLLSMYPWTSDGKYTGTIPPELLQSFGDFASPFGLNAMAEIFRAFGYNSGIAYGNYTNLPALYMLNAASMSVMQVLLGPSTTTFKVKGGCYSVYRGMSDYLGSENIVLNATVTELTRSFFLSTKSPRLRGYTTRADGSTDNFEYECEKVVVAHPPTLDDLSYVDLTQNEQDLFSNVEVAYYYAGVADISSSYLNGNSFQVMNADPSSEYNVPFGPGLISLGRYVDYGPTQIQAISNTNLEVCDMLEIITRDFENIPSWILNSFDIKTFDQHKEYAPHFNLASLSNPVSPYAKLAELQGSNNTYWVSALNRYTAATAHVWDEANIIVNTYFPSKN
What are the official names of this protein?
Uncharacterized protein R656.
What are the subcellular locations of this protein?
Secreted.
Protein: LEPA_GEOMG
Sequence: MKIENIRNFSIIAHIDHGKSTLADRLLEYTGALSERERQDQFLDKMDLERERGITIKAQTVRLNYRADDGKDYVLNLIDTPGHVDFTYEVSRSLAACEGGLLVVDASQGVEAQTLANVYLAIDNNLEVFPVLNKIDLPAAEPERVKHEIEEIIGLDAHDAVLASAKEGIGTREILEEIVKKIPPPEGDPAAPLKALLFDSWYDQYQGVIILARLIDGILKKGDKIQLVSTGRSYEALKVGVFAPVMREVPQLSAGEVGFVIAGIKDVADAKIGDTVTHTLKPCTTPLGGFKEVKPMVFSGLYPIDTSQYEQLRDALAKLKLNDSSFSYEPETSLALGFGFRCGFLGLLHMEIIQERLEREFNLDLITTAPTVVYRVHRIKGDMISIESANQLPPTQEIDYVEEPFILASIHTPNEFVGGILALCEEKRGVQREIKYLTPTRVMIIYELPLNEVVLDFYDRLKSITKGYASLDYEHLDYRRSELVRMNIMINGEVVDALSLIIHRDKAYYRGRDLVSKMKELIPRQMFEVAIQAAIGAKVIARETVKALRKDVLAKCYGGDITRKRKLLEKQKEGKKRMKNVGNVELPQEAFLAILKVEE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ATNC_ARTSZ
Sequence: MALVNNPIQAFANVALLFAVQILIPAFLIITTPKYSWLRYFGIPCIAFPAYLIFQLAPTLSNSIFHNSFLACEGILVVAHCVNLLLILQDGGLTWSDLRRSGVAGEKSETPPDATFLRKLISAVRLVVSLRGVDTPWEAKNTPPHPSSLGPGGGSRASFLIRQGAILAWQYLFLDVLLEVTKQEPPENTDKFYRPGMEYEYLNLTAEERFIRAFMPFVSWFVVSRLLLDSTWRALSILFVASGLGSPQSWRPLFGSMWDAYTLRNFWGKFWHQILRWPFTSNVNFLTRRVVKLPVPSLLDRYTNNFLVFLLSGILHAVSANIMGLSAVESGSIPYFSSFALGMMLEDGVQAFYNRLHADKERKTGIWKKVVGFIWVVFWMSLTSPWYMFPSRRKVAGEAAWVLPFNLTEVIGMPMMWGLLGTFGMLVKWAFGTSL
What is the function of this protein?
Acetyltransferase; part of the gene cluster that mediates the biosynthesis of the meroterpenoids arthripenoids (PubMed:29797385).  The pathway begins with the HR-PKS atnH that catalyzes two chain-extension steps to form a reduced triketide, which then primes the SAT domain in the NR-PKS atnG to initiate three more cycles of extension to give a linear hexaketide corresponding to the polyketide part of arthripenoids (PubMed:29797385).  The FAD-dependent monooxygenase atnJ then performs an oxidative decarboxylation at C11 of the atnH/atnG product, via an electrophilic aromatic hydroxylation with concomitant ipso-decarboxylation (PubMed:29797385).  The membrane-bound polyprenyl transferase atnF then introduces a farnesyl group before the FAD-dependent monooxygenase atnK functions as the first epoxidase on terminal C12'-C13' olefin, followed by a second epoxidation on C7'-C8' catalyzed by atnA (PubMed:29797385).  The terpene cyclase/mutase atnI then initiates the sequential tricyclic ring formation through protonation of the terminal epoxide and catalyzes the regioselective and stereoselective 6/6/6-tricyclic ring formation (PubMed:29797385).  The cytochrome P450 monooxygenase atnM is responsible for hydroxylating both C1' and C10' (Probable).  The next steps may involve ketoreduction and acetyl transfer by the ketoreductase atnB and the acetyltransferase atnC, and lead to the production of arthripenoid B, the final biosynthetic product of the atn cluster (PubMed:29797385).  The hydroquinone moiety in arthripenoid B is prone to undergo spontaneous oxidation to afford a benzoquinone compound, a key intermediate for generating structure diversity (Probable).  For instance, addition of a cysteine followed by ring contraction gives arthripenoid A, tautomerization gives the main product arthripenoid C, addition of a molecular of water or amine affords arthripenoid D or E, respectively, and loss of one water forms arthripenoid F (Probable).
What are the official names of this protein?
Acetyltransferase atnC, Arthripenoid biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the wax synthase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NHAA_SHEFN
Sequence: MERAIKNFLSQESAGGILLMVAVALAMILANSPLAGVYQGFLATEVQLRVGDLDIDKPLLLWINDGLMALFFLLIGLEVKRELLEGALSSVAKASLPSIAAIGGMVFPALFYLAFNYATPETQVGWAIPAATDIAFALGIMALLGNRVPVALKVFLLALAIIDDLGVIVIIALFYSTDLSMTSLVIAAVSIVLMVALNKKGVSSILPYGLLGFILWVAVLKSGVHATLAGVIIAFCIPLRAKDGTSPSEHLEHKLHPWSTFMILPVFAFANAGLSLTNMTLDSFAEPITLGIIMGLLLGKPIGVLLFSYLAVKLKLAELPPGIGWRHIIPVAVMCGIGFTMSVFIASLAFEHSPAAYGDYARLGILTGSLLAALIGYFWLAKVLPETGEKHETH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CBID_METBF
Sequence: MIDPVNNFKIPEDWIARTGLPREELETKVASGMLVVLSDGSILKRGYTTGTTASAAAKAAVLSLKKTVDNVSVPTPVGLRARLEVSEASQGRAVVKKIQNDHESDITRGLDFVGEAREAEGIRVLGGKGIGIVRRDGLQVPKGQPAINPKPMEQIKAAVQEAVEELSLRGAEVTISIPDGERIGKETLNSRIGVEGGISVLGSTGFVEPWNDHLGETRGDLIRCTDKVVLTTGRIGMRYSHMLFPDYTIVMIGSRISEGLDYASGDVVICGLPGLVLKWGNPDMLKDGEYATVVEMLEKDPEHPRLKEAFEMAIEKGKGARIVVIDRDGSVLMDSKNES
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: TNFB_PIG
Sequence: MTPPGRLYLRRVCSTPILLLLGLLLALPPEAQGLPGVGLPPSAAQPAHQHPPKHLARGTLKPAAHLVGDPSTPDSLRWRANTDRAFLRHGFLLSNNSLLVPTSGLYFVYSQVVFSGEGCFPKATPTPLYLAHEVQLFSSQYPFHVPLLSAQKSVCPGPQGPWVRSVYQGAVFLLTQGDQLSTHTDGTPHLLLSPSSVFFGAFAL
What is the function of this protein?
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity).  In its heterotrimeric form with LTB binds to TNFRSF3/LTBR.  Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
What are the official names of this protein?
Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane- associated.
Protein: OBG_ACTP2
Sequence: MKFIDEALIRVEAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVYLIADENLNTLIDYRFEKRYAAGRGENGRSAGCTGHRGNDITLRVPVGTRAIDNDTQEVIGDLTKHGMKMLVAKGGYHGLGNTRFKSSVNRAPRQKTNGTPGEKRDLLLELMLLADVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVARVGADRSFVVADIPGLIEGAADGAGLGIRFLKHLERCRVLIHLVDIMPIDESDPAQNISVIESELYQYSEKLSEKPTWLVFNKIDTIGEEEAQARAQEIAEQIGWEGDYYLISAATGQNVQNLTRDIMDFIEANPREVAEENTEADEVKFKWDDYHQQAMQNPIEEDWDNFDDDWSEEDEEGVEFVYTRS
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POLG_PWVMI
Sequence: KDEIIDAGIDGKKGGGKKDTQDAGESNKGKEKDKDINAGSKGSGVPRLQKITKKMNLPMVKGSMVLDLDHLIEYKPDQTKLFNTRATDAQFATWYEGVKAEYELSDDQMGVIMNPFMVWCIENGTSPDINGVWVMMDGDEQVEYPLKPMVENAKPTLRQIMHHFSDAAEAYIEMRCASGPYMPRYGLLRNLRDKNLARYAFDFYEVNAKTSDRAREAVSGEKAAALSNVTNKLFGLDGNVATISEDTERHTARDVNQNMHTLLGMGAPQ
What is the function of this protein?
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae genome polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein]: Virion.
Protein: HLDE_ALKEH
Sequence: MKITLPPFDQARVLVAGDLMLDRYWHGGTDRISPEAPVPVVHVRDIEQRPGGAGNVALNVAALGGQPELVGITGQDEAANELASLLENAGVACHFRRQPGAATITKLRVISRHQQLIRLDFEDGFPGAHARDLLPQYRPLLAGCGAVVLSDYAKGALRDPRPLIEAAREAGVPVLADPKGRDFSIYRGATLITPNLAEFEAVVGRCADEDTLVRRGEALARECGIEALLVTRGEDGMSLVRPGEAPVHLAARAREVFDVTGAGDTVIATLATGLATGLALPQAMALANLAAGIVVGKLGTATVSVAELRRALQEQEQSGRGVLTEPELLHAVADARAHGERIVMTNGCFDLLHAGHVAYLEQARSRGDRLIVAVNDDASVRRLKGEGRPINPVQQRMAVLAGLASVDWVVPFSEDTPARVIGAVLPDVLVKGGDYQPEAIAGHDAVVAHGGRVEILDFLDGCSTSAMIERMQSAPDT
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: CHLL_SYNY3
Sequence: MTLTLAVYGKGGIGKSTTSCNISTALAKRGKKVLQIGCDPKHDSTFTLTGFLIPTIIDTLQEKDFHYEDIWPEDVIYKGYAGVDCVEAGGPPAGAGCGGYVVGETVKLLKELNAFDEYDVILFDVLGDVVCGGFAAPLNYADYCLIVTDNGFDALFAAKRIAASVREKARTHSLRLAGLIGNRTSKRDLIDKYIEAVPMPVLEILPLIEDIRVSRVKGKTLFEMAESDPSLNYVCDYYLNIADQILSQPEGVVPKDAQDRDLFSLLSDFYLNPTQPASQTKELDLMMV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: PAN1_AJECN
Sequence: MYSNTFYGGSSSRPGPTGFGQQQPPPPPPPPPPQQQQQQQQPQQQPFPGFSQPQQQNLQPGAFMPQATGFAGSNPMQQMQMPMQQPQPTGFPPSHQFTGFPLQNQQPPSAVTAVTQQQLSAPLPNPPHETGMTSTQIAHSFAQPATPAVPAQQHASSGSKIPNMRLSFITAQDQAKFEQLFKSAVGNNQALDGETAKDLLMRSKLPGSDLSNIWVLSDTTKSGRLLFPEFALAMYLCNLKLTGKELPSVLPERIANEVSSMVDIISFAVPDARPAPPQTNVPKFDAPLMQNASAPPAPQQPQPQQPSNTQLLSQLTSQPTGFYNQATGLQPPSIVQPQQTGFPAQNAGLRPQQTGFLSNTQPTGYNGPRPPMPPMPTGYGSGLSPSQTGLAPLNAQPTGVPGQWGFVNAPATGLPNIEALQQRLMPQPGREGGFTTQGLSGNATIPWAVTKDEKKIYDQLFRAWDGFNKGFIGGDVAIEIMGQSGLERQDLERIWTLSDPNNRGRLNMDEFAVAMHLIYRKLNGYPVPNRLPPELIPPSTRNFNDSIGTVKSLLSQDAESRKSSGAFLQPQQTGVSYLKNHSFRSGSSTPGAGRKDATVFKNNDDAIGDRREAESLMERIRRVQDDIDTDPKAAFRITDSGAERRSLRRQLQSYQDQLPELASNVRKVERSIADARLELFRLKDAKAHPSAAAAIVGTGPGGTVTESDRIKARARARMQARAAELAGRPPPSTDDDGAAARRLEEETASVKAERERNDAMTRDVEESVKEFTRSLEDSLKDVDENSTREHERRRWEEALGVEDTIRDFIYDLQRASRTARVRKDERTASSQRSVSNNRYDNVSSNGDTLPVRPSQPQSTGSPSLAGLTHQERVTSAKERAQKRIAERMAAAGLKPNSDGSGETLLERQEREKREREERRKRAEEEDAKREQERQRRIAEEQNGPPVKAATTGKKPPPPPSRKGKADGVSPAETRKLGDLKNAAREKAEHEGKERALREEQLAQEAESRRLEAEARQQEEELAREREAAQARLRALEEQVRQGKIKKQEEKRRKQLAEKEAKEKEARLAIQRAELEAAQARERELQRQLEGLDEEESSDDEGPVEVTPQNSTPTQSAVLPSATTTMASPPSVPRPATPPAAPFEPELAFEVASATSTSIPSPESVKQRVAADTESRNPYFRKMGQSVDTQPPSFHTPPEQIPDPLSTTEVAPPPASAPAPPKTEIQSTNPFHRLAQQQESQKSAFAAAPLPGPLTRKSRARPEDDEWSIAESENSSDDDDDRPAGGSAKHLASILFGTMGPPRPLSAMDEKPESKSATPVQESPTVAASPPPPPPPPPPPSEPAPVTTLPPAVAAQDVEEDDDDDDENDFQDAPSMPPPPPPPPVPAPFADAPPTAPPPPPPPAFSAAAPPPPPPPPPVGGAPGGPPPPPPPAGDAPAIPKAAVPDAGAGRGALLASIQAGKGLRKVETKDRSAASVSGRVL
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein PAN1.
What is the protein family that this protein belongs to?
Belongs to the PAN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: RGS5_HUMAN
Sequence: MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.  Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).
What are the official names of this protein?
Regulator of G-protein signaling 5, RGS5.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Membrane. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: LUXS_LIMRD
Sequence: MAKVESFTLDHTKVKAPYVRLITVEEGPKGDKISNYDLRLVQPNENAIPTAGLHTIEHLLAGLLRDRLGGVIDCSPFGCRTGFHLITWGEHSTTEVAKALKSSLEEIAYKTKWEDVQGTTIESCGNYRDHSLFSAKEWSKKILDEGISDKPFERHVVD
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: MDH_PSEMZ
Sequence: DDLFNINAGIVKLFGVTTLDVVR
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: ACT2_PLAFX
Sequence: MSEEAVALVVDNGSGMVKSGLAGDDAPKCVFPSIVGRPKMPNIMIGMEQKECYVGDEAQNKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVSPEEHPVLLTEAPLNPKTNREKMTQIMFETFDVPAMYVSIQAILSLYASGRTTGIVLDSGDGVSHTVPIYEGYVLPHAINRIDMAGRDLTYHMMKLFTERGHTFTTTAEREIVRDIKEKLCYIAMDYDEELKRSEEHSDEIEEIYELPDGNLITVGSERFRCPEALFNPTLIGRECPGLHITAYQSIMKCDIDIRKELYNNIVLSGGTTMYNNIGERLTKEMTNLAPSSMKIKVIAPPERKYSVWIGGSILSSLSTFQQMWITKEEYEDSGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm.  Polymerizes into longer and more stable actin filaments compared to ACT1/actin-1.  Has ATPase activity.  ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi.  ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin.  Plays an essential role in male gametocyte development in the mosquito midgut, functioning in several processes including male gametocyte egress from host erythrocytes, formation of a beating flagellum and relocalization of ACT1/actin-1 to the cytoplasm.  On the basal side of the mosquito midgut epithelium, required for the development of ookinetes into sporogonic oocysts.
What are the official names of this protein?
Actin-2, Actin II.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MMP1B_MOUSE
Sequence: MPSLPLLLRLWAASSYSFPVIQDGLQKNVKTVWKYLENYYNLGKNMQAKNVNGKEVMAEKLRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPDVAPYAITHNNPRWTKTHLTYSILNYTPYLSKAVVEDAIARAFRVWSDVTPLTFQRVFEEEGDIVLSFHRGDHGDLYTFDGSKYHFAHAFLPGLGLGGNVHYDLDQKWTDNNEDFNLFYVTAHELGHSLGLSHSNDEEALMFPSYTWSNKDFVLNQDDINRIQALYGPSPNPIQLTDATLDPCNSGLTFDAIITYRGEVIFFKDRFYIRVISFLPEPLIDVIDLTWPNLPGKFDAAYEVSGVDELRFFKGSKVWAVQEQNVLEGFPMDIQSFFGFPSNVTNIDAAVCEEETGKTYFFVDHMYWRYDENTRSMDPGYPRLIAEDFPGIDYKVDDVIQKEDNFYFFHQSIQYRFNLKTRRIDDSSDINTWFNC
What are the official names of this protein?
Interstitial collagenase B, Matrix metalloproteinase-1b, MMP-1b, Mcol-B.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: PSBP3_TOBAC
Sequence: MASTQCFLHHHALSTPARTSLVRGIVPSLKSNQLLVCRAQNKQSAPQQDNVNSVSVSRRLALTLLIGAAAVGSKVSPADAAYGEAANVFGKPKTDTDFQTYNGDGFKLQIPSKWNPNKEVEYPGQVLRFEDNFDATSNVIVAITPTDKKSITDFGSPEQFLSQVDYLLGRQAYSGKTDSEGGFESDAVAIANVLETSTAEVGGKQYYYLSILTRTADGNEGGKHQLVTATVNDGKLYICKAQAGDKRWFKGAKKFVENTATSFSLA
What is the function of this protein?
May be involved in the regulation of photosystem II.
What are the official names of this protein?
Oxygen-evolving enhancer protein 2-3, chloroplastic, OEE2, 23 kDa subunit of oxygen evolving system of photosystem II, 23 kDa thylakoid membrane protein, OEC 23 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the psbP family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: INSL1_ECOLI
Sequence: MNYSHDNWSAILAHIGKPEELDTSARNAGALTRRREIRDAATLLRLGLAYGPGGMSLREVTAWAQLHDVATLSDVALLKRLRNAADWFGILAAQTLAVRAAVTGCTSGKRLRLVDGTAISAPGGGSAEWRLHMGYDPHTCQFTDFELTDSRDAERLDRFAQTADEIRIADRGFGSRPECIRSLAFGEADYIVRVHWRGLRWLTAEGMRFDMMGFLRGLDCGKNGETTVMIGNSGNKKAGAPFPARLIAVSLPPEKALISKTRLLSENRRKGRVVQAETLEAAGHVLLLTSLPEDEYSAEQVADCYRLRWQIELAFKRLKSLLHLDALRAKEPELAKAWIFANLLAAFLIDDIIQPSLDFPPRSAGSEKKN
What is the function of this protein?
Involved in the transposition of the insertion sequence IS186.
What are the official names of this protein?
Putative transposase InsL for insertion sequence element IS186A.
What is the protein family that this protein belongs to?
Belongs to the transposase 11 family.