PharMolix/UniProtQA huggingface dataset:
Protein: RPAC1_DICDI
Sequence: MVNKSTTNGVSDPNLENKRTKVTLTNSGVENARGTYYSGAYTSVGYDNSFNLNRFKENFKINILSESANELVFEMIGIDAPIANALRRIMISEIPTMAIEKVYIINNTSILQDEVLAHRLGMIPIKVDPRKFNFKLPNKEYTAEDTLIFQLKVKCEKDSVTGKIINETALSKHLIWVPTQDQEEMFPNEEDRPRPMEDDIPIMKLRPGQVIDIQCYCEKNIGREHIKWSPVCTASYRLQPVISVDKSIKGDKANQLLEKCPKKVFDIEDSGQVVAARPLDCTMCRECIRDPEFEQNVKIERVRDHFIFSIESTGALKSREIFQEAIKIFIEKCNIVEESINKLVN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.  RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerases I and III subunit rpac1, RNA polymerases I and III subunit AC1.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HOG1_TORDE
Sequence: MATHEEFIRTQVFGTVFEITNRYTDLNPVGMGAFGLVCSATDTLAQQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMTEGKPLFPGKDHVHQFSIITDLLGSPPEDVINTICSENTLKFVTSLPHRDPVPFRERFKTVEPEAVDLLEKMLVFDPKKRITAADALVHPYLAPYHDPTDEPVADAKFDWNFNDADLPVDTWRVMMYSEILDFHKIGGGDGQIDTSATFDDQVAAATAAAAHAAAVAQAQAQAHSNSSNSNSSSNVNSKSKAARDSANDAITNYGNQAVHYANEFQQ
What is the function of this protein?
Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment.  Controls osmotic regulation of transcription of target genes (By similarity).  Involved in resistance to osmotic stress and tolerance to methylglyoxal and citric acid.
What are the official names of this protein?
Mitogen-activated protein kinase HOG1, MAP kinase HOG1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TPX_SALTY
Sequence: MSQTVHFQGNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLATEVENTVVLCVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGVEIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYDAALNVLKA
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: SYR_DEHM1
Sequence: MNSILAIKNIIIESLSQALEKARQEGQIPALSVDISIEHPQKTNYGDYATSLPLRLAKATGKRPMELAEILAGYIEPGEGIAKVSVAPPGFINFTFSKEWLCNLVKTILGEAESYGNINMGGGSRVQIEFVSANPTGPIHIGHGRGAVLGSTLSNVLKAAGYYVEEEFYINDAGSQIDAFKRTLFARYQQALGKEAAVPQDGYHGQYMVELAAEMVAKYGDKYLQMPLEIAQNDLGEIGMARMLCLISDDLKSLKVDFDVWFSERSLYSGGQYKTAMDILLANNYIAERDNATWFSSTLLGDSKDNVIVRSDGTPTYFASDIAYHYNKFIERKFDRVINIWGADHQGHVSRMKAMLSALGINPERLTTLLFQMITLKRGGELVRLSKRTGEMISLSEVIEEVGADACRFFFLSRSTESQMDFDLELAKKESAENPVYYVQYAHARICSILSLAKEKGLSYSGGDTALLGEEAELELIRKMAELPEIVETVARTLEPHHLTYYAQELANAFHQFYKDCRVISDNTELSSARLKLVDASRIVLARTLHLMGMTSPQSM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BECN1_DANRE
Sequence: METLRFSSNTMQVSFVCQRCNQPLKLDTSFNVLDRMTIHELTAPLVMVTANKQQDSGESSSFPEETFLENKQDGVARKFIPPARMMSAESTNSFTLIGEASDGGTMENLSRRLKVTSNLFDIMSGQTDIDHPLCEECTDTLLDHLDTQLNITENECQNYKSCLELLSQLPEEEEASLLNALQQLKQEEESLIQELESIETKREAVAKELDEGRNHSQLMDTEELRYQKEYCEFKRQQLELDDDLKSVDNQMRYCQIQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALASKMGLCFQRYQLVPYGNHSYLESLSDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKDDTGFCLPYRMDVDKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNR
What is the function of this protein?
Plays a central role in autophagy (PubMed:24441423, PubMed:27467399, PubMed:28445460).  Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity).  Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity).  Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (By similarity).  Involved in endocytosis including endosome formation in neuronal cells (By similarity).
What are the official names of this protein?
Beclin-1.
What is the protein family that this protein belongs to?
Belongs to the beclin family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Endosome. Cytoplasmic vesicle, autophagosome.
Protein: ETV6_MOUSE
Sequence: MSETPAQSSIKQERISYTPPESPVASHRSSTPLHVHTVPRALRMEEDSIHLPTHLRLQPIYWSRDDVAQWLKWAENEFSLRPIESNKFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKSRMLFSPFFPPGDSIHTKPEVLLHQNHDEDNCVQRTPRTPAESVHHNPPTIELLHRPRSPITTNHRPSPDPEQQRPQRSPLDNMSRRLSPVEKAQGPRLQQENNHQETYPLSVSPVENNHCLPSSPWQESTRVIQLMPSPIMHPLILNPRHSHSVDFKQSRHSEDGMNREGKPINLSHREDLAYLNHIMVSMSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQVLDEQTYQEDEPTIASPVGWPRGNLPTGTAGGVMEAGELGVAVKEETRE
What is the function of this protein?
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'.  Plays a role in hematopoiesis and malignant transformation.
What are the official names of this protein?
Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNH_EHRCJ
Sequence: MKDELNKVVIYTDGACSGNPGPGGWGAILLFDKNERTICGNNPDTTNNRMELTAVIEALKFLKVAYNVDLYTDSIYVKDGITLWIEKWKINGWRTASKLPVKNLELWLELDSLASFHNVTWYWVKAHAGNLYNQKADILARSQISK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATF_THET8
Sequence: MAVIADPETAQGFRLAGLEGYGASSAEEAQSLLETLVERGGYALVAVDEALLPDPERAVERLMRGRDLPVLLPIAGLKEAFQGHDVEGYMRELVRKTIGFDIKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit F, V-ATPase subunit F.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase F subunit family.
Protein: RL22_MYCSK
Sequence: MTTATTNPSTYPNAMAVARYVGISASKARRVIDLVRGKSVEEALDILRWAPQQASEPVAKVIASAAANAQNNEGLDPSTLVVATIHADEGPTAKRIRPRAQGRAFRIRKRTSHITVIVESRPSREGRRGGAGESAGGARARRAQGSKAAAAKKAPASSSKKAATTTEASEEAKGGSQ
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: NRPB_SOYBN
Sequence: MENNNQSFWQFSDQLRLQASNLANLSLNDSIWSNNYISKRRDERINFDIKVGGEINSFKSKDPACDYNDNVNGSLLAMPYNNNNNNNIILGFGGVGLNGGFNKGIYSKPAFANLNNNINLNINPKGHKGKVEDELFHPSKSSKKNNNLNKKHGDNNNNDNNKDSKAAGDKRFKTLPPSESLPRDETIGGYIFVCNNDTMAENLKRQLFGLPPRYRDSVRAITPGLPLFLYNYSTHQLHGIFEAASFGGTNIDPSAWEDKKCPGESRFPAQVRVITRKTCEPLEEDSFRPILHHYDGPKFRLELNVPEALSLLDIFAEQDTFNDAFEALPA
What is the function of this protein?
Involved in stress signaling pathway that mediates cell death in response to endoplasmic reticulum (ER) stress and osmotic stress.
What are the official names of this protein?
DCD domain-containing protein NRP-B, N-rich protein B.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLD_RICCN
Sequence: MNNTILILKNISKHYSQGKTIVRVLDDLNLTVNEGELIAIIGSSGSGKSTLLHIAGLLDKPTKGQVIIPNSKYQKYHLIRLHYLGFIYQQHHLLKDFTALENVIMPRLISGLDQKEAIEDATKILDDLGLGKKLYNMPGELSGGEKQRVAIARSLINKPKIILADEPTGNLDPKTTNEVFNLFLKVAREQNTAIIMVTHNYELAHKMDKLYKLKHRLLNIA
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ARND_PSEAB
Sequence: MIQAGLRIDVDTFRGTRDGVPRLLDLLDEAGLKATFFFSVGPDNMGRHLWRLARPAFFWKMLRSRAASLYGWDILLAGTAWPGKPIGRELGPLMRRTQAAGHEVGLHAWDHHAWQTHVGVWSAQQLGEQIRRGSDCLADILGQPVRCSAAAGWRADGRVVEAKQPFGFRYNSDCRGRGAFRPRLADGSPGIPQVPVNLPTFDEVVGPGLPREAYNDFILERFAAGRDNVYTIHAEVEGLLLAPAFRELLRRAERRGIRFRPLGELLPDDPRSLPLAELVRGRLAGREGWLGVRQP
What is the function of this protein?
Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
Protein: U512O_DICDI
Sequence: MTLFNSISSISNSTGLYKQSLIANVDGMTISSSGNSSSWLSGFDGCGGCGGFGGCGGGFGGCGGSNLNIINVDMNIGRRHRRCC
What are the official names of this protein?
UPF0512 protein O.
What is the protein family that this protein belongs to?
Belongs to the UPF0512 family.
Protein: PYVB_ASPV1
Sequence: MIASHLLSPLIFLEQQPAYSSVVIGALVVCLVCLVWPTESAKRAPPAPNFGVPRIGDAAAFLADPVSFVQKATQKCGSIFQIKLLVANLVYLRGVKLNRMYTDVKEDTWSFGGGIGLFLRKIAKPGYFDHLRTLVNSLNRGVNRKAALEHYFQLIEEEAGKALQGWSQRGAVPVFEETSRFVHRVIVRCLMGQDFYDHRLDELYEILHHMEADIGHPFNLLLPDWIPHPAARRLEQNRDRFAQIFEQQVADRRRNPEIWRDSLDYISFTLEDPRTAHLEGYLPSHHTVLMFAAHTSTVASISWTILELLRNPDYLAQLRQSLAAHPDARKCPELLAGIKETGRHYSGVHMFRTTHRAVELEGGKYLVPPNWIVSISPYLTHHDPEIFHTPQHWIPERWLQPDDRMQNLNNPREAAFLQFGAGCHRCPGEALAGIIAQGLLATLVRRYDMVWGKEGPPTDLTALDFSKVGSPWLEGDASIAIRPKVAE
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pyranoviolin A, a pyranonigrin analog with a C-3 methoxy group (PubMed:33117309).  Initially, the PKS portion of pyvA synthesizes C-10 carbon chain from 5 molecules of malonyl-CoA, which is then condensed with the thiolation (T) domain-bound glycine activated by the adenylation (A) domain (PubMed:33117309).  The subsequent chain release by Dieckmann condensation (DKC) could be catalyzed by the TE domain present at the C-terminus of pyvA and/or the alpha/beta hydrolase pyvD, installing the tetramic acid moiety (Probable).  The FAD-dependent monooxygenase pyvC next epoxidizes one of the olefins of the polyketide part, and the epoxide ring-opening induces the dihydro-gamma-pyrone ring formation (Probable).  The cytochrome P450 monooxygeanse pyvB would be responsible for the 2 consecutive reactions, in which the dihydro-gamma-pyrone is oxidized to gamma-pyrone and C-7 is hydroxylated to yield pyranonigrin F (Probable).  Finally, the O-methyltransferase pyvH methylates the C-3 hydroxy group to complete the biosynthesis (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase pyvB, Pyranoviolin A biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PP189_ARATH
Sequence: MSVLVRLTSKIASLAKSGRIASARQVFDGMPELDTVAWNTMLTSYSRLGLHQEAIALFTQLRFSDAKPDDYSFTAILSTCASLGNVKFGRKIQSLVIRSGFCASLPVNNSLIDMYGKCSDTLSANKVFRDMCCDSRNEVTWCSLLFAYMNAEQFEAALDVFVEMPKRVAFAWNIMISGHAHCGKLESCLSLFKEMLESEFKPDCYTFSSLMNACSADSSNVVYGRMVHAVMLKNGWSSAVEAKNSVLSFYTKLGSRDDAMRELESIEVLTQVSWNSIIDACMKIGETEKALEVFHLAPEKNIVTWTTMITGYGRNGDGEQALRFFVEMMKSGVDSDHFAYGAVLHACSGLALLGHGKMIHGCLIHCGFQGYAYVGNALVNLYAKCGDIKEADRAFGDIANKDLVSWNTMLFAFGVHGLADQALKLYDNMIASGIKPDNVTFIGLLTTCSHSGLVEEGCMIFESMVKDYRIPLEVDHVTCMIDMFGRGGHLAEAKDLATTYSSLVTDSSNNSSWETLLGACSTHWHTELGREVSKVLKIAEPSEEMSFVLLSNLYCSTGRWKEGEDVRREMVERGMKKTPGCSWIEVGNQVSTFVVGDSSHPRLEELSETLNCLQHEMRNPETFGP
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g36980, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ASSY_STRTD
Sequence: MSKEKVILAYSGGLDTSVAITWLKKDYDVIAVCMDVGEGKDLEFIHDKALTVGAVESYVLDVKDEFAEDYVLPALQAHAYYEQKYPLVSALSRPIIAKKLVEIAHKTGATTIAHGCTGKGNDQVRFEVAIAALDPSLKVVAPVREWKWSREEEIEYAKANGVPVPADLDNPYSVDQNLWGRANECGVLENPWNQAPEEAFGITNSPESAPDEAEYVDVTFKEGKPVALNGKEMKLADLIQEMNVIAGKHGVGRIDHVENRLVGIKSREIYECPGAIALLTAHKEIEDLTLVREVSHFKPILENELSNLIYNALWFSPATEAIIAYIKETQKVVNGIAKVKLYKGHAQVVARQSANSLYDENLATYTSADSFDQDAAIGFIKLWGLPTQVNSQVNHPFDK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_BARBK
Sequence: MTAETKRVGATGGMENSFGFTQIDEAQKQSMVDGVFHSVAENYDRMNDILSLGLHRIWKNSMITWLAPPAISGWKVIDVAGGTGDIAFRILNASRKKAHATVLDINHSMLNVGKKRAQINGLAPFIDFVEANAEQLPFSDQSFDAYTIAFGIRNVPHIDKALSEAFRVLKPGGRFLCLEFSNVEMPLLDKLYDLWSFHAIPKLGQLIAGNSDAYRYLVESIRMFPKQDDFACMINRAGFSRVSYRNFTGAIAALHSGWKI
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: YYCB_BACSU
Sequence: MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELHMSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAALFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLATQMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFMGLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRGIVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAAALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYIFQSEKQRNSA
What are the official names of this protein?
Uncharacterized transporter YycB.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ASPP2_MOUSE
Sequence: MMPMFLTVYLSNSEQHFTEVPVTPETICRDVVDLCKEPGENDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFLRHERPPNRDIVSGPRSQDPSVKRNGVKVPGEHRRKENGVNSPRLDLTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLREIAESQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDGHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVSELRDRLWKKKAALQQKENLPVSPDGNLPQQAVSAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLLMQSAEGPMKIQTLPNMRSGAASQSKGSKAHPASPDWNPSNADLLPSQGSSVPQSAGTALDQVDDGEIAVREKEKKVRPFSMFDTVDQCAAPPSFGTLRKNQSSEDILRDAQAVNKNVAKVPPPVPTKPKQIHLPYFGQTAQSPSDMKPDGNAQQLPIAATSVGAKLKPAGPQARMLLSPGAPSGGQDQVLSPASKQESPPAAAVRPFTPQPSKDTFPPAFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTQPRGPHFSSVYGKPVIAAAQNPQQHPENIYSCSQGKPGSPEPETETVSSVHESHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSHPSKSPGSVTVNPESSVEIPNPYLHVEPEKEVGSLVPEPLSPEDMGSASTENSDVPAPSAGLEYVSEGVTDSSTNLQNNVEETNPEAPHLLEVYLEEYPPYPPPPYPSGEPEVSEEDSARMRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQHDDELLMKEGDCMTVIRREDEEEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA
What is the function of this protein?
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (By similarity).  Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo.  Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis.  Impedes cell cycle progression at G2/M.  Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity).
What are the official names of this protein?
Apoptosis-stimulating of p53 protein 2, Tumor suppressor p53-binding protein 2, 53BP2, p53-binding protein 2, p53BP2.
What is the protein family that this protein belongs to?
Belongs to the ASPP family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear.
Protein: RS3_GEOSM
Sequence: MGQKVNPIGFRLGVIKTWDSKWYAEKDYAKLLHEDLKLRNFLKKRLYHSGVSKIEIERAAGKAKINIFTARPGLIIGKKGSEVETLKKELAKLTEKEVYLNIQEVRKPELDAQLVAENVAMQLERRIAFRRAMKKSVTSTLKFGAKGIRITCSGRLGGAEMSRTEWYREGRVPLHTLRADIDYGFAEAKTTYGIIGVKVLLFKGEVLSAKK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CD244_RAT
Sequence: MLQQTVLLSLFLLLRAHQGQDCADSSEEVLGVSGKPVRLRPSNIQAKHVSIEWKKKTGHQQTPQIVTWDTTDNKNFNMCCSDIYGFESENFALSIKSAKLNDSGHYLLEITNQRGIVCTKNFQMLIFDPVETPHLTVQGTLWANGTCQLSLSCFVPKDDNVSYALYRGSMLISNQRYGTHWENRTDASSLHTYTCNVSNKASWANHTLTSPQSCQSVPSKFNYLPFMVSIGILVKFFHGAIDCFCVWNRKRKQSQSIAKESLTIHEYVKNAQVSRDQRGHFRASGSSSDVRGDERGQRESDRRLFQFINRS
What is the function of this protein?
Modulate other receptor-ligand interactions to enhance leukocyte activation.
What are the official names of this protein?
Natural killer cell receptor 2B4, NK cell type I receptor protein 2B4, NKR2B4, Non-MHC restricted killing associated.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GPDA_SALPB
Sequence: MNQSNASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIATLEHDRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFSDVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDETFADDLQQLLHCGKSFRVYINADFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLTEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVKGAQDKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKEELSRH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_MOUSE
Sequence: MSLVIKNLQRVVPIRRVPLRRKMDLVRSILGVKKFDLGIICVDNKTIQNINRIYRNKNVPTDVLSFSFHENLKAGEFPQPHSPDDYNLGDIFLGVEYILQHCRESEDYCDVLTVTATHGLCHLLGFTHSSKAEWQKMYNQEKLVLEELSRYTGARLQPLSRGLY
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in rRNA maturation.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
Protein: Y739_SYNAS
Sequence: MSGHSKWSTIKRKKGAIDSKRGKIFTKIIKEITLAARLGGGDTEGNSRLRQAILAAKNENMPRDNIDRAIKKGTGEIGGGESYEEVTYEGYGPGGVAVLVEVMTDNKNRTVAEIRHIFSKHGGNLGGNGCVSWLFEKKGSIVFDRDLIDEDALMELALEAGAEDIREEESQMDVITDPSMFDKVRDVLEGKGMKYVQASIEMVPQNTIRLDEGKAEQMLKMIEKLEDNDDVQNVYANFDIPDEIMEKLSA
What are the official names of this protein?
Probable transcriptional regulatory protein SYNAS_07390.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP183_HUMAN
Sequence: MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
What is the function of this protein?
G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity).  Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711).  Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity).  Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity).  Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity).  Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity).  Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878).  Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity).  Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity).  Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity).  Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897).  Promotes osteoclast precursor migration to bone surfaces (By similarity).  Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897).  Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity).
What are the official names of this protein?
G-protein coupled receptor 183, Epstein-Barr virus-induced G-protein coupled receptor 2, EBI2, EBV-induced G-protein coupled receptor 2, hEBI2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.