PharMolix/UniProtQA huggingface dataset:
Protein: LYSC_TRAOB
Sequence: MRALIILGLVLLSVTVQGKIFERCELARTLKKLGLDGYKGVSLANWVCLAKWESGYNTEATNYNPGDESTDYGIFQINSRYWCNNGKTPGAVDACHISCSALLQNNIADAVACAKRVVSDPQGIRAWVAWRNHCQNKDVSQYVKGCGV
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.  Also plays a role in digestion in this species.
What are the official names of this protein?
Lysozyme C, 1,4-beta-N-acetylmuramidase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KIF5C_HUMAN
Sequence: MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK
What is the function of this protein?
Microtubule-associated force-producing protein that may play a role in organelle transport.  Has ATPase activity (By similarity).  Involved in synaptic transmission (PubMed:24812067).  Mediates dendritic trafficking of mRNAs (By similarity).  Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
What are the official names of this protein?
Kinesin heavy chain isoform 5C, Kinesin heavy chain neuron-specific 2, Kinesin-1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, dendrite. Note=Abundant in distal regions of dendrites.
Protein: PAND_MYCTU
Sequence: MLRTMLKSKIHRATVTCADLHYVGSVTIDADLMDAADLLEGEQVTIVDIDNGARLVTYAITGERGSGVIGINGAAAHLVHPGDLVILIAYATMDDARARTYQPRIVFVDAYNKPIDMGHDPAFVPENAGELLDPRLGVG
What is the function of this protein?
Overexpression of wild-type protein confers resistance to pyrazinoic acid (POA), the active form of the anti-tuberculosis prodrug pyrazinamide (PZA).
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRB_SALPB
Sequence: MANQPSAEELKKKLSEMQFYVTQDRGTEPPFTGRLLHNKRDGVYHCLVCDTPLFHSHTKYDSGCGWPSFYQPVSEEAIRYIDDFSHGMQRVEIRCGNCDAHLGHVFPDGPQPTGERYCVNSASLAFSDEKNGDQLKG
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrB, Peptide-methionine (R)-S-oxide reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrB Met sulfoxide reductase family.
Protein: Y1334_VIBC3
Sequence: MEFEFIKNTLLGEYAVRCNMEHQIVGRWLQEEIGQDLAKLKHVLTLIDKAEQSPAQEFLWTGREISLLVQGDEITVQENALAYESEHELETDFALYDSESIAACGREDFVALLTQWQSFIQNQGRF
What are the official names of this protein?
UPF0231 protein VC0395_A0134/VC395_0622.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: FTSH_CORGL
Sequence: MKNKKYLQFGGIAAVILIVLFLVSLFSSDTRNFQEVDTSVAMAQLDAGNVAEAQIDDREQRVRLTLREPITVDEREGVEEILAQYPARTAPAIFEKVEASNTDSYTTNVTQESFLMSMLSFILPMVIIFGLLMFFLTRMQGGGMFGIGGSKAKQLTKDMPTNTFADVAGAEEAVDELHEIKDFLEDPTRYEALGAKIPRGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFKQAKENSPCIIFVDEIDAVGRARGSGMGGGHDEREQTLNQLLVEMDGFGDRQGVILMAATNRPDVLDPALLRPGRFDRQIPVTNPDLRGREQILEVHAKGKPFAPDADIKALAKRTAGMSGADLANVLNEAALLTARVGGNVITADALEEATDRVVGGPRRSGKVISEKEKKVTAYHEGGHTLSAWALEDIERVYKVTILARGRTGGHAMTAQEDDKGMYNRNELFARLVFAMGGRSAEELVFGEPTTGASADIEMATKIARSMVTEYGMSPAVGMVKYGQEQGDPFSGRGGGGNLDHSQEVAATIDTEVQFLLDKAHEVSYSILAEYRDHLDRLAEKLLEKETLRRPDLEALFDDIVPRKVAEVFPDESTRFPRQENREPVKTPVELALERGEEPPKKFSILEASRATRERRRKELEAQGKLPVQPASSAGVAPAAGAAAGSYGTPPPADWSVPGSAGKHRSRAEEQPAEQGFPAQTPAQAPEQSPDSSGGRPNPYATPTASGEHPGMKAYGFGDSELMDQSTGAEHTPGNVSQESPTEMIGFRLPDHERSDYPEKAQKESVLDASETTEMPVVPDQPIDGDSGKSAEGTQENPENEGDNRG
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: ATPA_PINKO
Sequence: MGNLQIDEISSIIRKQIKQYNDAVGVGNLGTVLQVGDGIARIHGLYEVMAGELVEFGDGTVGIALNLGSDNVGVVLMGDGLMIQEGSSVRATGKIAQIPVSDAYLGRVVNALAQPIDGKGQISASEFRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQKSQNVICVYVAIGQRASSVAQVVNTFQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYKKQHTSIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSQLGEGSLTALPIVETQAGDVSAYIPTNAISITDGQIFLSADLFNAGIRPAINVGLSVSRVGSAAQIKAMKKVAGKLKLELAQFAELEAFAQFASDLDKATQDQLARGQRLRELLKQSQSAPLKVEEQIATIYTGTNGYLDILEIAQVRNFLVRLREYLIKNKPQFGEIICSTGTFTEEAKALLEEAL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ISPE_BACAA
Sequence: MKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKEKFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTPPSCWVILAKPHIGVFTADVYGNLKLNRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKRFGADAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQVYAVRLLGERETLE
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: CSPL6_ORYSJ
Sequence: MDLEKGKKPSEQAAACRIMQVKDKLITLQPVVRACVFLATAVAAVIMGLNKQSYTTVVAIVGTRPVTQTFTAKFKDTPAFVFFVIANAIASGYNLMVLVTRRILQRRAQSLSVHLLDMVILTLLATGSATAASMAQLGKNGNLHARWNPICDKFGSFCNHGGIALVSSFIGVALMLALNLLSAAANSPRSNVTGQ
What are the official names of this protein?
CASP-like protein 1B1, OsCASPL1B1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PHAE_PHAVU
Sequence: MASSNLLSLALFLVLLTHANSASQTSFSFQRFNETNLILQRDATVSSKGQLRLTNVNDNGEPTLSSLGRAFYSAPIQIWDNTTGAVAASPTSFTFNIDVPNNSGPADGLAFVLLPVGSQPKDKGGLLGLFNNYKYDSNAHTVAVEFDTLYNVHWDPKPRHIGIDVNSIKSIKTTTWDFVKGENAEVLITYDSSTKLLVASLVYPSLKTSFIVSDTVDLKSVLPEWVIVGFTATTGITKGNVETNDILSWSFASKLSDGTTSEALNLANFALNQIL
What is the function of this protein?
This insecticidal carbohydrate-binding lectin is toxic for the cowpea weevil.
What are the official names of this protein?
Erythroagglutinating phytohemagglutinin, PHA-E.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: SSGB_KINRD
Sequence: MLVGNSWTRSLEPVSGHEHTEVDVPALPHRKTEVDVDVSLRLRTTSGPGLPVPASLHYGADDPYAIHAVFRGGDTDVEWVFARDLLREGLSAPAGAGDVQVQPCSDSPDGRPRVLLRLSSPDGNAELEADESDVRRFLRRADALVPPGRETRHLDLDELIARLVS
What is the function of this protein?
Involved in sporulation-specific cell division (PubMed:19567872).  Required for early stages of sporulation.  Important in the process of growth cessation prior to sporulation-specific cell division.  Recruits cell division protein FtsZ to the future septum sites and tethers the contractile ring structure (Z ring) to the cytoplasmic membrane during sporulation.  Stimulates polymerization and filament length of FtsZ in vitro (By similarity).
What are the official names of this protein?
Sporulation-specific cell division protein SsgB, Sporulation of Streptomyces griseus-like protein B, SsgA-like protein B, SALP B.
What is the protein family that this protein belongs to?
Belongs to the SsgA family.
What are the subcellular locations of this protein?
Cell septum. Note=Localizes to the divisome in sporogenic aerial hyphae in a ladder- like manner. Temporospatial localization is controlled by SsgA and it colocalizes with SsgA in presporulation foci. Localizes to the septum sites prior to FtsZ and after that colocalizes with FtsZ at the divisome throughout cell division.
Protein: CH60_LACLA
Sequence: MSKDIKFSSDARTAMMRGIDILADTVKTTLGPKGRNVVLEKSYGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPVGIRRGIELAAETAVASIKEMAIPVHDKSAIAQVATVSSRSEKVGEYISDAMERVGSDGVITIEESKGMQTELDVVEGMQFDRGYLSQYMVSNTEKMVAELDNPYILITDKKISNIQEILPLLEQILKTNRPLLIVADDVDGEALPTLVLNKIKGVFNVVAVKAPGFGDRRKAQLEDLAILTGGTVITEELGLDLKDATLEALGQAAKATVDKDHTTIVEGAGSADAISDRVAIIKAQIEKTTSDFDREKLQERLAKLAGGVAVVKVGAATETELKAMKLLIEDALNATRAAVEEGIVSGGGTALVNAIAALDKLSEEGDIQTGINIVRRALEEPVRQIAANAGYEGSVIIDKLRSEEVGTGFNAATGQWVNMIEEGIVDPAKVTRSALQNAASVAGLILTTEAVVANKPEPAAPAMPPMDPSMGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_STRAW
Sequence: MPATPNNVPEPSRTDPALIRNFCIIAHIDHGKSTLADRMLQLTGVVDQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPTQEPGNTHILNMIDTPGHVDFTYEVSRSLAACEGTVLLVDAAQGIEAQTLANLYLAMENDLKIIPVLNKIDLPAAQPEKFSEELANLIGCDPEDVLKVSAKTGLGVEALLDKVVAEVPAPVGVADAPARAMIFDSVYDSYRGVVTYVRVIDGQLNKRERIRMMSTGATHELLEIGVSSPEMKPADGLGVGEVGYLITGVKDVRQSKVGDTITTLNKGATEALGGYKDPKPMVFSGLYPLDGSDYPELRDALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLDVIRERLEREFGLDLIATAPNVVYRVLMEDGSEHTVTNPSEFPEGKISEVYEPVVRATILAPSEFIGSIMELCQTRRGTLLGMDYLSEDRVEIRYTLPLAEIVFDFFDQLKSKTRGYASLDYEPTGEQASSLVKVDILLHGDKVDAFSAITHKDAAYAYGVRLVAKLRELIPRQAFEVPIQAAIGSRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGSVEVPQEAFIAVLSSDDSGGSAKGKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PUR9_STRCO
Sequence: MTATAGSNKRAIRRALVSVYDKTGLEDLARGLHEAGVELVSTGSTAGRIAAAGVPVTKVEELTGFPECLDGRVKTLHPKVHAGILADLRLESHRQQLDELGVAPFDLVVVNLYPFRETVASGATPDECVEQIDIGGPSMVRAAAKNHPSVAVVTSPARYADVLLAVEGGGFDLAARKRLAAEAFQHTAAYDVAVASWFAAEYAPVDESGFPDFLGATYERANTLRYGENPHQPAALYTSPEGGGLAQAEQLHGKEMSYNNYTDTDAARRAAYDHAEPCVAIIKHANPCGIAIGADVAEAHRKAHDCDPVSAYGGVIAVNRPVSKEMAERVAGIFTEVIVAPDYEDGALEALTKKKNIRVLRAPAAPAAPVEVKPIDGGALLQVTDRLQAEGDDPATWTLATGEALSEAELAELAFAWRACRAVKSNAILLAKDGASVGVGMGQVNRVDSAKLAVERAGAERAQGAYAASDAFFPFPDGLEILTGAGVKAVVQPGGSVRDELVVEAAKKAGVTMYFTGTRHFFH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: URE3_STACT
Sequence: MHFTQREQDKLMLVVANDLARRRQSRGLKLNYPEAVAIISYEMLEGARDGKSVAELMSYGRQILNKDDVMEGVSDMIPDLEIEATFPDGTKLITIHHPIV
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPPB_MYCPN
Sequence: MFIVMTIVFFLVNSTGQTPLSATSSKDLEAVKTQLDAFGFNDPLIVRYGRYWQTLFSGSLGTYYSSPNQTIDQIVFGRVPNTLYVVLISFFIGSLLGIIFGMISGLFRGKLIDAVINVLVVLFVSIPSFVVGLGLLKAAGLFRLPPRFINFDDANFNFGNFLLASIIPILSLVFYTSAAFTYRVRNEVVEVMNQDYIKTARSKGLSTFAVALYHIFRNSIIPSVPLFVFGISGAFSGGFIIESLFGVQGVSRILIDSVQSNETNLVMFNIMFIQGIPLLASVFIELIYVLVDPRIRIASAGGVSLWTKLKFVYLRQAWLRKWRRINHTNSHNVLFNSPQHRQLLELKAIDYKHNTISLTEQQKTTLKIEPTANFVLLGTKCLKIITIHG
What is the function of this protein?
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Oligopeptide transport system permease protein OppB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAMLG_HUMAN
Sequence: MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGSEVP
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539).  Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539).  Required for the stability of GET1 (PubMed:32187542).  Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304).  Essential for the survival of peripheral follicular B cells (By similarity).
What are the official names of this protein?
Guided entry of tail-anchored proteins factor CAMLG, Calcium signal-modulating cyclophilin ligand.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RTNLQ_ARATH
Sequence: MESTPPYHRSNTKSASRLQDSSNPPNLSLDLVLSSPNTPNPSSPVPLRDILLLPPSPLRKSRTRLSDRLEMTSEDAMAVVRKRGKGKGGQKSLLASPRNPRRSRRRSEAVEEKEANLVIEEIVKLPPRKRKTNGRPKKDKQSSAPPLCSSSDLPNTCQSDLNLIGEIISDLVMWRDVAKSTLWFGFGCLSFLSSCFAKGVNFSVFSAVSNLGLVLLCGSFLSNTLCQRKNEDTKRAFHVSEDDVLRSARRVLPATNFFISKTSELFSGEPSMTLKVTPFLLLGAEYGHLITLWRLSAFGFFLSFTIPKLYSCYTHQISQKVERVKTRIGEAWGVCSHKKILAGSAVTAFWNLTSIRTRIFAVFIILVIFRYRRQNLQLTPEEVEPVENEQEEETLPQEEETVPQEEETVPQEEEQTQPSEERALVVVVAET
What are the official names of this protein?
Reticulon-like protein B17, AtRTNLB17.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MVP_ORSVS
Sequence: MGRLRFVVLLSIFPIKTFSEPCSTMALVLRDSIKISEFINLSASEKLLPSALTAVKSVRISKVDKIISYENDTLSDIDLLKGVKLVENGYVCLAGLVVTGEWNLPDNCKGGVSICLVDKRMKRANEATLGSYHTSACKKRFTFKIIPNYSVTTADALKGIWQVMINIRGVEMEKGFCPLSLEFVSICVVYLNNIKLGLREKILNVTEGGPTELTEAVVDEFVEKVPMAARLKSFRSVNKKKPSDSSKFVNGKSRLNSRNKLNYENGDSDVGISVVDDIVVGNGVSDIRIDDDCESFDAQSDPY
What is the function of this protein?
Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding.  The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier.  Forms a ribonucleoprotein complex with viral RNA.  Binds microtubules and modulates microtubule stability.  Can bind double-stranded DNA.
What are the official names of this protein?
Movement protein, 30 kDa protein, Cell-to-cell transport protein.
What is the protein family that this protein belongs to?
Belongs to the tobamovirus movement protein family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton. Host cell junction, host plasmodesma.
Protein: APOE_MASCO
Sequence: MKALWAVLLVTLLTGCLAEGEPEVADELAWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQSSEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKSGAREGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALGDRIRGRLEEVGNQARDRLEEVREHMEEVRSKMEEQTQQIRLQAEIFQARLKGWFEPLLEDMQRQWANLVEKIQASVATNPITSTPMPEEN
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: HEM1_POLNA
Sequence: MSVWALGLNHHTAPLDLRGRFAFAIDQIEPTLRGLRASLARQPEATLLSTCNRTEIYCAGDTNDLDSTMEWLAHNGGVSPSLLRAHAYTLQDDQAARHAFRVASGLDSMVLGEPQILGQMKDAVRAAEDAGAMGTTLHQLFQRSFAVAKEVRTSTEIGAHSISMAAAAVRLAGQLFEDLGDIKVLFVGAGEMIDLAATHFAAKNPKAMAIANRSLDRGEKLASRFGAEVMRLGDLPGRLHEFDAVISCTASTLPIIGLGAVERALKRRKHRPMFMVDLAVPRDIEPEVKELSDIYLYTVDDLAHVVQTGRDSRQAAVAEAEVIIDAGVQNFMHWLDQRGSVPLIQQLNAQADAWRAAEIVRAKKLLARGESIEEVLEAMSRGLTQKMLHGAMAELHAGDASSREATARTVSKLFLRGQMPRAATERKER
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: EASC_EMENI
Sequence: MEETNVKLSVPLSEDVIKLSALDQQIMRFYAKAVFIFERDSSKTSIDIVHHLKQGLAVTLSEIPDLAATIAPVPNSHRKDLELRIGPNSGVPFKVVDQTKQESWVYGTYPDLAAKHFPTSDIPHDILFIPQPQPSADGLPAAFLQVNIIDGGVIIAISWHHSVCDARGISILIDAWARHTATSLANGKPDLPATPAEGSRDRWRLDHGLREVTIDQLPEYTIDSSAREDPSGSYLLDRENPVTVPYSVSTWYFSASSLKALRDALAQVENDESTQFTKVEAVSALVWKHMSIARQLDRSNPDGSSLFTTRLDFRARTKPPFPDTFIGNINEPTARVRLPIAEICRASTPESLTTLAEAVRAATENTTEQSMRTLIGLVNDAPAVTDVAWKYNYFPGPDLGVTDISNIDAMKKNWGAGLGTPTCVRSYSRETGLLYLFPQDDDGGFEIQVQCEVEAVERLKADETFTRYCEFKRASAYNA
What is the function of this protein?
Acyltransferase; part of the gene cluster that mediates the biosynthesis of emericellamides, secondary metabolites acting as antibiotics (PubMed:18559263).  The biosynthesis of emericellamides initiates from the highly reducing polyketide synthase easB which catalyzes the formation of the linear polyketide chain (PubMed:18559263).  EasB produces several polyketides that can be further processed by the downstream enzymes (PubMed:18559263).  The polyketides are released from easB as linear polyketide carboxylic acids, which are converted to CoA thioesters by the acyl-CoA ligase easD (PubMed:18559263).  The substrates are then loaded onto the acyltransferase easC, which shuttles them to the first thiolation (T) domain of the nonribosomal peptide synthetase easA (PubMed:18559263).  EasA then performs condensation of the polyketides with one glycine, two alanine, one valine and one leucine residues (PubMed:18559263).  A last step of cyclization leads to the production of emericellamides (PubMed:18559263).
What are the official names of this protein?
Acyltransferase easC, Emericellamide biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: ADD_SALEP
Sequence: MIDITLPLTDIHRHLDGNIRAQTILDLGRQFNIALPAQTLETLIPHVQVTSTEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPIAGVVEAVIDGVRDGCNTFGVEARLIGIMSRTFGEAACLQELDALLAHRENITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRALMDFLVQQRIGIESCLTSNIQTSTVASLADHPLKTFLEHGVLASLNTDDPAVQGVDIIHEYHVAAPAAGLSREQIRQAQINGLEIAFLSDGEKRALREKVAAA
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.