PharMolix/UniProtQA huggingface dataset:
Protein: ZFAN1_MOUSE
Sequence: MAELDIGQHCQVQHCRQRDFLPFVCDGCSGIFCLEHRSKDSHGCSEVNVVKERPKTDEHKSYSCSFKGCTDVELVAVICPYCEKNFCLRHRHQSDHDCEKLEVAKPRMAATQKLVRDIVDAKTGGAASKGRKGAKSSGTAAKVALMKLKMHADGDKSLPQTERTYFQVYLPKGSKEKSKAMFFCLRWSIGKVVDFAASLANLRNENNKLTAKKLRLCHVPSGEALPLDHTLERWITKEECPLYNGGNVILEYLNDEEQFLKNVDSYLE
What is the function of this protein?
Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover.  SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress.  Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome.  This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy.
What are the official names of this protein?
AN1-type zinc finger protein 1, Zinc finger AN1-type-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm, Stress granule. Note=Colocalizes with TIA1, G3BP1, VCP and 26S proteasome in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment in a VCP-independent manner. Not localized in SGs in response to other heat- oxidative- or osmotic- induced stress treatments. Colocalizes with VCP in cytoplasmic speckles.
Protein: MATK_TRILP
Sequence: MKEYQVYLERARSRQQDFLYPLIFREYIYGLAYSHNFNRSIFLENVGYGNKYSLLNVKRLITRMYQQNHLIISANDSNKNPFLGYNKNFDSQIISEGFAIVVEIPFFLQLSSSLEEAEVIKSYKNVRSIHSIFPFLEDKFTYLNYVSDIQIPYPIHLEILVQILRYWVKDAPFFHLLRLFLYHFCNWNRFITTKKSISTFSKSNPRLFLFLYNFYVCEYESIFLFLRNKSSHLRLKSFSVFFERIFFYAKREHLVEVFAKDFSYTLPLFKDPNIHYVRYQGKCILASKNAPFLMKKWKHYFIHLWQCFFDVWSQPRTININQLSEHSFRLLGYFSNVRLNRSAVRSQMLQNTFLIEIVSKKLDIIVPIIPLIRSLAKAKFCNVLGHPISKPVWADSSDFDIIERFLRICRNLSHYYNGSSKKKSLYRIKYILRLSCIKTLACKHKSTVRAFLKRSGSEELLEEFFTEEEEILSLIFPRDSFTLHRFHRNRIWYLDILFSNDLVNDE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: THIG_XYLFA
Sequence: MNNFASNDPLVIAGIVYSSRLLTGTGKFKDLDETRLATEAAGSQIVTVAIRRVNIGQDPHQPNLLNVLSPDRYTILPNTAGCYTAEDAVRTCRLARELLDGHRLTKLEVLGDKKTLYPDVVQTLKAAEQLVAEDFQVMVYTSDDPILAKRLEEIGCVAVMPLAAPIGSGLGVQNRYNLLEIIENAQVPIIVDAGVGTASDAAIAMELGCDAVLMNTAIAGARDPVLMASAMRKAVEAGREAFLAGRIPRKRYAAASSPVEGLVG
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYX_AZOVD
Sequence: MNMSLETRINDLETRLAFQDDTIQALNDVLVAQQRVVERLQMQLEALAKRQEELIEEFGSVDDDGAPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: TEG5_VZVO
Sequence: MQSGHYNRRQSRRQRISSNTTDSPRHTHGTRYRSTNWYTHPPQILSNSETLVAVQELLNSEMDQDSSSDASDDFPGYALHHSTYNGSEQNTSTSRHENRIFKLTEREANEEININTDAIDDEGEAEEGEAEEDAIDDEGEAEEGEAEEDAIDDEGEAEEGEAEEDAAEEDAIDDEGEAEEDAIDDEGEAEEDAIDDEGEAEEDYFSVSQVCSRDADEVYFTLDPEISYSTDLRIAKVMEPAVSKELNVSKRCVEPVTLTGSMLAHNGFDESWFAMRECTRREYITVQGLYDPIHLRYQFDTSRMTPPQILRTIPALPNMTLGELLLIFPIEFMAQPISIERILVEDVFLDRRASSKTHKYGPRWNSVYALPYNAGKMYVQHIPGFYDVSLRAVGQGTAIWHHMILSTAACAISNRISHGDGLGFLLDAAIRISANCIFLGRNDNFGVGDPCWLEDHLAGLPREAVPDVLQVTQLVLPNRGPTVAIMRGFFGALAYWPELRIAISEPSTSLVRYATGHMELAEWFLFSRTHSLKPQFTPTEREMLASFFTLYVTLGGGMLNWICRATAMYLAAPYHSRSAYIAVCESLPYYYIPVNSDLLCDLEVLLLGEVDLPTVCESYATIAHELTGYEAVRTAATNFMIEFADCYKESETDLMVSAYLGAVLLLQRVLGHANLLLLLLSGAALYGGCSIYIPRGILDAYNTLMLAASPLYAHQTLTSFWKDRDDAMQTLGIRPTTDVLPKEQDRIVQASPIEMNFRFVGLETIYPREQPIPSVDLAENLMQYRNEILGLDWKSVAMHLLRKY
What is the function of this protein?
Tegument protein that can bind to various RNA transcripts.  Plays a role in the attenuation of selective viral and cellular mRNA degradation by modulating the activity of host shutoff RNase ORF17/VHS.  Also plays a role in the primary envelopement of virions in the perinuclear space, probably by interacting with two nuclear egress proteins ORF24 and ORF27.
What are the official names of this protein?
Tegument protein UL47 homolog.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae HHV-1 UL47 family.
What are the subcellular locations of this protein?
Virion tegument. Host nucleus. Host cytoplasm. Note=Major tegument protein of the virion. Undergoes nucleocytoplasmic shuttling during infection. Localizes to the major sites of transcription in the infected cell nucleus.
Protein: NDRG4_RAT
Sequence: MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTLFNLEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLATMLPNVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLMNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQISSVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAHLKDRRLSGGAVPSASMTRLARSRTASLTSASSVDGSRPQPCTHSDSSEGMGQVNHTMEVSC
What is the function of this protein?
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity).  May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by NGF.  May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
What are the official names of this protein?
Protein NDRG4, Brain development-related molecule 1.
What is the protein family that this protein belongs to?
Belongs to the NDRG family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: YME1_CAEEL
Sequence: MQSAINLNIGGLLQNTGLLRNSRNGINRKPLDIEATAASLSRVYHQVWRQFSSDTSSPVTINQMNNILRDSTLSRRIARKSEISLNYDDAVVRIIPASSSFYIQRRGFRTRKQTFGVGNAGKPTQDEVKSPLTYFSELLAGKKQKTSEGGVEKWNQYESDLKKLPENQQRTYTDGFVKGLLSNGVSGAGKDGKKSNTLTRFYIFLVFCIFFGYLTGRIRVRVGDRQIGSLFFSNPQEVNPEDVQVTFDDVRGMDEAKLEVEEIVDYLKDPEKYSRLGGRLPKGVLLVGPPGTGKTLLARAIAGEAQVPFFHTAGSEFDEVLVGQGARRVRDLFDKAKARAPCIIFIDEIDSVGSKRVSNSIHPYANQTINQLLSEMDGFTRNEGIIVIAATNRVDDLDKALLRPGRFDVRVTVPKPDLAGRVDIFNFYLSKIVHSGGIDPKVLAKGSTGFTGADIENMVNQAALKAATDNAVEVTMAYLDEARDRVLMGPARTGGRIPDEEANRNTAYHEAGHTLVSLYTKDATPLHKVTIIPRGQSLGHTAMLPEKDSYQLTKAQMLATLDVMMGGRVAEELIFGDDKVTTGAADDLSKATQLAVQMVKVFGMSDKVGLRDFTAQDNESALVKVSDLAPQTAELIDAEINRVLQESYKRAKVILETKKKEHQLLAEALLEYETLSADEVKRVISGQKIKRPTPAAVKKSNETKRNQPSLVLHLFEEEGRGKQ
What is the function of this protein?
ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity).  Plays an important role in regulating mitochondrial morphology and function (By similarity).
What are the official names of this protein?
ATP-dependent zinc metalloprotease YME1 homolog.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Mitochondrion.
Protein: APOA_HUMAN
Sequence: MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEPTQADIALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWGETQGTFGTGLLKEAQLLVIENEVCNHYKYICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN
What is the function of this protein?
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)).  It has serine proteinase activity and is able of autoproteolysis.  Inhibits tissue-type plasminogen activator 1.  Lp(a) may be a ligand for megalin/Gp 330.
What are the official names of this protein?
Apolipoprotein(a), Apo(a), Lp(a).
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Plasminogen subfamily.
Protein: DCTA_ANASK
Sequence: MKRLARSLYLQVLLAVVLGALVGHLFPATGASLKPLGDGFIKLVKMLIAPIVFATVVTGIAKMGDLRKVGRVGLKGLLYFEVLTTVALAIGLVVARLARPGAGMNVDPATLDTKAIASYTNGAQAHGTVDFLMNVIPRDVADAFARGDILQVLLFSVLFGAALAALKDKGRPVLEFVDGLSLVLFRIVGFVMRLAPVGAFGAMAFTVGKYGIATLLSLGKLIACFYATSALFVVLMLGLVLRWCGLSLFRFLRYIKEEIFVVLGTSSSESALPLMMRKMEKLGCSKPVVGLVVPMGYSFNLDGTSIYLTLATLFIAQATNTHVTLVQELEILAVLLLTSKGAAAVTGGGFITLAATLSAVGNIPVAGLALLLGVDRFMSEARAITNLIGNGVASVAVSRWEGELDQARARAVLAGTVPEEVEPANEPEPPAIPAGAGLHG
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUCG_HUMAN
Sequence: MRALRAGLTLASGAGLGAVVEGWRRRREDARAAPGLLGRLPVLPVAAAAELPPVPGGPRGPGELAKYGLPGLAQLKSRESYVLCYDPRTRGALWVVEQLRPERLRGDGDRRECDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLEKYSRSLTRSYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIELRTYVMPNAPVDEAIPLERFLVPIESIERASGLLFVPNILARAGSLKAITAGSK
What is the function of this protein?
Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (PubMed:25355512).  The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity).  Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (By similarity).  Promotes conservative recombination when the DNA is 5hmC-modified (PubMed:25355512).  Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (PubMed:33473107).  GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (PubMed:33473107).  Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (PubMed:29719607).
What are the official names of this protein?
Endonuclease G, mitochondrial, Endo G.
What is the protein family that this protein belongs to?
Belongs to the DNA/RNA non-specific endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SPT20_RAT
Sequence: MSHHSPPPPKHKGEHKGHGLPRGSERGSSSRGKDRSASVSNSVPMPAGGKASRTNCPPPAPQKTANRLINEKSPYLLQHAHNPVDWYPWGQEAFDKAKKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGHLLNENFVSVMVDREERPDVDKVYMTFVQATSSGGGWPMNVWLTPSLQPFVGGTYFPPEDGLTRVGFRTVLMRICDQWKQNKNTLLENSQRVTTALLARSEISVGDRQLPPSAATMNSRCFQQLDEGYDEEYGGFAEAPKFPTPVILNFLFSYWLSHRVTQDGSRAQQMALHTLKMMANGGIRDHVGQGFHRYSTDRQWHIPHFEKMLYDQAQLSVVYCQAFQISGDEFFSDVAKGILQYVTRNLSHRSGGFYSAEDADSPPERGVKPQEGALYLWTVKEVQQLLPEPVGGASEPLTSGQLLMKHYGLSEAGNINPTQDVNGEMHGQNVLTVRDSLELTGARYGLEVEAVRALLNTGLEKLFQARKHRPKAHLDNKMLAAWNGLMVSGFAVAGSVLGMEKLVTQATNGAKFLKRHMFDVSSGRLKRTCYAGAGGTVEQSNPPCWGFLEDYAFVVRGLLDLYEASQESSWLEWALRLQDIQDKLFWDSHGGGYFCSEAELGTDLPLRLKDDQDGAEPSANSVSAHNLLRLHGLTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRALSAQQQTLKQIVICGDPQAKDTKALLQCVHSIYIPNKVLILADGDPSSFLSRQLPFLSNLRRVEDRATVYIFENQACSMPITDPCELRKLLHQ
What is the function of this protein?
May play a role in fertility regulation.
What are the official names of this protein?
Spermatogenesis-associated protein 20, Sperm-specific protein 411, Ssp411.
What are the subcellular locations of this protein?
Secreted.
Protein: RS3_CUPTR
Sequence: MGQKIHPTGFRLAVSRNWASRWYASNTKFAGMLKEDIEVRDFLKKKLKNASVGRVVIERPARNARITIYSSRPGVVIGKKGEDIELLKAELQRRMGVPVHVNIEEIRKPETDAQLIADSITQQLERRIMFRRAMKRAMQNAMRLGAQGIKIMSAGRLNGIEIARTEWYREGRVPLHTLRADIDYGFSEAETTYGIIGVKVWVYKGDHLGRNDAPVVEEPQDDRRRRPGRPEGRRREGEGRPGGNRRGGAGAGRRAAPGADAKSGE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: BAP2_YEAST
Sequence: MLSSEDFGSSGKKETSPDSISIRSFSAGNNFQSSSSEKTYSKQKSGSDKLIHRFADSFKRAEGSTTRTKQINENTSDLEDGVESITSDSKLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLHYGGPAALIIGYILVSFVTYFMIQAAGEMAVTYPTLPANFNAYSSIFISKSFGFATVWLYCFQWLTVLPLELITASMTIQFWNDKINPDIYILIFYVFLVFIHFFGVKAYGETEFIFNCCKILMIAGFIILSIVINCGGAGNDGYIGATYWHNPGAFAGDTSIGRFKNVCYILVTAYFSFGGMELFALSVQEQSNPRKSTPVAAKRSIYRIVVIYLLTMILIGFNVPYNDDQLMGAGGSATHASPYVLAASIHGVKIVPHIINAVILISVVSVANSSLYAGPRLICSLAQQGYAPKFLDYVDREGRPLRALIVCCVFGVIAFVAASSKEEIVFTWLAAIAGLSELFTWTSIMLSHLRFRQAMKVQGRSLDELGYKATTGIWGSIYGVFFNILVFVAQFWVALAPLGNGGKCDAESFFQNYLAFPIWLAFYFGYMVYNRDFTLLNPLDKIDLDFHRRIYDPELMRQEDEENKEKLRNMSLMRKAYHFWC
What is the function of this protein?
Permease for leucine, valine and isoleucine.  Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan.
What are the official names of this protein?
Leu/Val/Ile amino-acid permease, Branched-chain amino-acid permease 2.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THIC_SYNS3
Sequence: MRTEWVSARKGQANVSQMHYARKGVVTEEMAYVAKIENLPESLVMEEVARGRMIIPANVNHTNLEPMAIGIASKCKVNANIGASPNASDAAEEVNKLKLAVKYGADTVMDLSTGGVNLDEVRTSIIGASSVPIGTVPVYQALESVHGSIEKLDEDDFLHIIEKHCQQGVDYQTIHAGLLIEHLPKVKGRLTGIVSRGGGILAQWMLYHHRQNPLFTRFDDICEIFKRYDCTFSLGDSLRPGCQHDASDAAQLAELKTLGDLTRRAWKHDVQVMVEGPGHVPLDQIEFNVKKQMEECNEAPFYVLGPLVTDIAPGYDHITSAIGAAMAGWHGTAMLCYVTPKEHLGLPNAEDVREGLIAYKIAAHAADIARHRPGARDRDDELSRARYAFDWNKQFELSLDPERAKEYHDETLPADIYKQAEFCSMCGPKHCPMQTKITDADLDGLEQVLKSQGAAELVGVKQDKL
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: DAPEL_LIMRJ
Sequence: MLTEEELIQIRRHLHQIPELALQEFDTHQYLVETIAGFNQAFLEVRTFKELPTALMVLVHGKNPQRTIGYRTDIDALPVEEQTGLPYSSTHPGVMHACGHDIHMTVALGVLNYFSEHQPQDNILFFFQPAEESENGGKRAYELGLFSGKWKPDEFYGLHDNPDLPAGAIGCRMGTLFAGTTEVNIDLNGKGGHAAYPQNANDTVVAAASLILQVQTVISRSIDPIQSGVITLGKIDGGTIRNVIAGHTRIEGTIRGLTQTMIETIDNRLKDVCEGIGCSFNMDVSLELNQGGYWPVENNPELTKRFIHYMEETPTVNFIETEPAMTGEDFGYLLAKFPGTMFWLGVEDDSQLHSATLTPNEKAIKRGVDAITGFLEYRMQN
What is the function of this protein?
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
What are the official names of this protein?
N-acetyldiaminopimelate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
Protein: KUP_BORBR
Sequence: MTHTAAGAPRDAKTAIHAPSSRMALMLGALGVVYGDIGTSPLYTLRACLNTIDDLQPAHVLGVLSILFWLLMIVVSLKYVTLVLRADNRGEGGTLALLELAVRGREGRARWLLIVLGIFGAALFYGDSMITPAISVLSALEGISIVSHTLEPWVVPVALVVLVALFAIQSHGTGAVGKLFGPIMALWFATLAVLGGYQIWLTPEVLAALNPVWALRFIAEFPVMSFLLLGAVVLALTGAEALYADMGHFGRPAIRRAWFAMVLPALTLCYFGQGALLLRDPAAIRNPFFLMAPEWGLAALVGLATVATVVASQAVISGAFSVTRQAVQLGFWPRMQILHTSAVEKGQIYLPQVNALLLCAVLVLVLLFRNSENLAAAYGFAVTGTMLTTSVLAFAVLPRDSTGGKRVLWMVLLGALLVIDILLFGANIFKIHEGGWLPLLVGVVVFTLMMTWRRGRRLLADMQARDRQPLREFMTQLEAFPPARVQGTAIFMTMNAGNVPPALLHNLKHNKVLHDHVLFLSIRVADVPYVSEDERFEMHKISASSWQASINYGFKEDPDVPDALRQVAEAYPEIDLEPMRTSFYLSRQTVVAARRPAMARWRRALFAFMARNSTRSTRFFKIPPNRVVEMGMQVEL
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYV_MYCGE
Sequence: MKDKFSFQKNYDFNLVSDGLYEIWNNAGFFKPKDKNNSFTAILPPPNLTGTLHIGHAFEVSITDQIMRFKKMQGFSINWIPGFDHAGIATQTKYEKIALKENQKYFDADDDKKSEMIMNWALNQSEIIKNQLKSLGVCLNWSETKFTLSEQANKIVNNCFKNLYENGFIYQAYTLVNWDTKLNTAISNIEVINKPVNQHLHYVVYKLANDSKQELIVATTRPETIFADVCLLVNPKDKRYTNFWNKLVVNPLTGKQIPVVTDSYVDIKFGTGILKCTPAHDFNDYEINTKYKFDFLSCIDSNGILNQNASKFQGLSVLQARNKIVKWLEKNKLLVKSIPLTSNVGFSERSGTVVEPMLSKQWFVDLPKLKDHLYLKKYPDFIPKRFNKQVSNWLNKLKPWCISRQLIWGHKIPVWFENNTGEIVVGEKPSKNLQNYTRSKDVLDTWFSSSLWPLICLNWEQDDSFHETELLVTGYDILFFWVLRMLFNSFFETKKLPFKTVLIHGLVRDEQNRKMSKSLNNGIDPVDLIRNYGADAVRLFLCSNHTPGDDLIFSEQKIKSAWNFLNKLWNVTKFVIQLENDQEISYDLDKLSLSETWILAKLDKVIQKITKLLDKFQLALANQILVKFVWDDFCNTFIEAIKKEPNQLKPQLFYTAKSVLSNIAILLSITVPFLSERIYQQFNNKSVMQATWPLATKIKIPKLFDLVLAAINDLRNYRKQYMLNSQQKLVVILSGKNAVDVKQYFNFSWIELKIETNKKVSFKYQIVDDTTQRLKSLQKQQAFFESEVKRSQAIVKNKSFLEKAPKEKVKSEFLKLEEYQKKLTETNQLIAKLTKAH
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPA_BURPS
Sequence: MNANNLLQAAIFIVVLIAAAVPVARYLTRVMDGSSAVVRVFGPLERALYRFAGIDPRTEMSWKQYALATVAFNALGVLFLYALLRVQGWLPGNPQGFGPMTVDGALNTAVSFVTNTNWQDYTPEQTVSYLAQMLGLTVQNFLSAATGIVVVLALIRGFARHTAQTIGNFWVDVTRVTLYVLVPMAAIIAALLMSQGVIQNTKAYQDVPTLQTTSYAAPRLDAQGNPVKDAKGNPVTVQTSVKAQTLAMGPVASQEAIKMLGTNGGGFFNGNSSHPYENPTPFSNFLEIFAILIIPAALCLVFGNTIGDRRQGVAVLAAMTVALAAAIGIETSAEQGGTPVLASLNVDLAASPLQAGGNMEGKETRFGIAQTGLFVVATTAASCGAVDAMHDSLTPVGGLVPMLLMQLGEVIFGGVGSGLYGMLVFALLAVFVAGLMIGRTPEYVGKKIESYEMKMVSIVVLLTPLLVLVGTSIAVLADAGRAGIANPGPHGFSEILYAFSSAANNNGSAFGGLSVNTPFYNWMTAIAMWFGRFGTIVPVLAIAGSLAAKKRIAATSGTLPTHGPLFVVLLLGTVLLVGALTYMPALALGPGVEHLMLFVGAH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: THIG_CUPNH
Sequence: MTFEPSETLRDPFVLYGESFGSRLLLGTARYPSPATLEAAVQASRPAMITVALRRQGAVGAGEGGQAFWQMLKALDVPVLPNTAGCFTAQEVITTAMMAREVFETPWIKLELIGDDYTLQPDTLNLPAVAETLIKEGFKVLPYCTEDLVLCRRLLDVGCQALMPWAAPIGTGRGAVNPHAMRVLRERLPDTPLIVDAGLGLPSHAAQVLEWGYDGVLLNTAVAQAAYPVNMARAFAQAVEAGRTAYLAGPMPEREVAQASTPVVGMPFWHADSTEQRA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOD_BURCM
Sequence: MAEIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAESKTFIQSVPYMDRLDYVSMMVNEHGYVLAIERLLGIDVPERAQYIRVLFDEITRVLNHLMWIGAHALDVGAMAVFLYAFREREDLMDVYEAVSGARMHAAYYRPGGVYRDLPDAMPQYKASKIRNEKALARMNEARSGSVLDFIDDFFTRFPKCVDEYETLLTDNRIWKQRLVGIGVVSPERALQMGLTGPMLRGSGIAWDLRKKQPYEVYDRMDFDVPVGVNGDCYDRYLVRVEEMRQSIRIAKQCIEWLRKNPGPVMTDNHKVAPPSRVGMKTNMEDLIHHFKLFTEGFHVPEGEAYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGFAHLASLDEMARGHMIADAVTIIGTQDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: XYLA_STRMR
Sequence: MSFQPTPEDRFTFGLWTVGWQGRDPFGDATRPALDPVETVQRLAELGAYGVTFHDDDLIPFGSSDTERESHIKRFRQALDATGMTVPMATTNLFTHPVFKDGGFTANDRDVRRYALRKTIGNIDLAAELGAKTYVAWGGREGAESGGAKDVRDALDRMKEAFDLLGEYVTAQGYDLRFAIEPKPNEPRGDILLPTVGHALAFIERLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQSGIKYDQDLRFGAGDLRAAFWLVDLLETAGYEGPRHFDFKPPRTEDFDGVWASAAGCMRNYLILKDRAAAFRADPEVQEALRAARLDQLAQPTAADGLDALLADRAAFEDFDVDAAAARGMAFEHLDQLAMDHLLGARG
What is the function of this protein?
Involved in D-xylose catabolism.
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.