Protein: ATR_ORYSI
Sequence: MANFSSHIQELRELIAASSTTTSTSAPASVHFEVKLREVLPNLLRDYVVPSSPTADGREATAVLKLLSYTAGKFPGVFFHGRAADVIRVIGRVLPFFAEPNFRSRHEIIFDTVWSLLSLLRTGDREAYRQFFLDVMVAVQDVLYVVASMHGDRPSGVLTERYLVKCLCGSFSDILDSPGIFSDLPDSCQPKNGPGVLVDLTGETRWRPFATMLIKLVNKCLADGTLYVEGLVNMPFVSAACSIICYGDESLHKVCFDFARIVATVITVEILPVENIIRSIMCILSQDVNGLSDIRDADYDFSMGACLHALHSSCPGYIVAITASDIVNVFQRAVHTSRSSELQVAMCNAYKRIVELCSPRVWKPEILLKLLCLPKPCAKLIECIRLVVDKSGQSFLSSDDRDDGSSLLAKSEGLDLPKVGQKRIALDEENSFPKRLKMTEPRFSSGSFMVDELSAGVGQELEKDHGCDFRVQLYSLINCLSPDNHMAYPLEPAIAIQVLSLLCLSLSVYPKTNLFSRISKQVLSWIPWICKQTTKICMFSFDVSLYFEAVQTVMLLQSFLPGHTKLFEDEPLLIGNGCTDFEYPRYADLINLLKLVSDDGYLTSQTCSEKLKCLAVQIIAKIGSRQNAECDLQVLELAIQSETGELQNEALMSLPIIVLYSGPRMLGAMFRKLETIGTLGCKKLWKSIAISLGFLSCLNGTTDCTDKVGNHCKLFLAKHCEQPILTLNLLRGFWCPQCDVRTVHIEDQVPIVDIALSEDKNIDFKINMFKAHSLFFKFLYAETSEECIVSIVEVLPRILKHSSRDVLLDMKFQWVQCVDFLLLHEMKAVRDAFSSVVSCFLETNAMDILFSDGTGMSGGTSRVKFMDKIKSAFTEAEDPQILLTLLESTAAIVKASDIHGEVFFCSFVLLIGQLGNHDYIVRVTALRLLQRCCTYCFKGGLELFLSKYFHVRDNLYDYLSSRLLTHPVVISEFAESVLGVKTEELIRRMVPSIIPKLIVSHQNNDQAVVTLNELASHLNSELVPLIVNSLPKVLSFALFYEDGQHLSSVLQFYHTETGTDSKEIFSAALPTLLDEIICFPGESDQIETDRRMAKISPTIQNIARILIGNDNLPEFLKNDFVRLLNSIDKKMLHSSDVNLQKQALQRIRKLVEMMGPYLSTHAPKIMVLLIFAIDKETLQMDGLDVLHFFIKRLAEVSCTSIKYVMSQVVAAFIPSLERCRERPLVHLGKIVEILEELVVKNIILLKQHIRELPLLPSLPSLSGVNKVIQEARGLMTLQDHLKDAVNGLNHESLNVRYMVACELNKLFNDRREDITSLIIGEDIADLDIISSLIMSLLKGCAEESRTVVGQRLKLVCADCLGALGAVDPAKFKVMSCERFKIECSDDDLIFELIHKHLARAFRAASDTTVQDSAALAIQELLKLSGCQSLPNESSSCKMSKRGQKLWGRFSSYVKEIIAPCLTSRFHLPSVNDATLAGPIYRPTMSFRRWIYYWIRKLTSHATGSRSGIFGACRGIVRHDMPTAIYLLPYLVLNVVCYGTPEARQSITEEILSVLNAAASESSGAIVHGITGGQSEVCIQAVFTLLDNLGQWVDDLKQEIALSQSNYAMAGRQGGKLRDESNSMYDQDQLLVQCSNVAELLAAIPKVTLAKASFRCQAHARALMYFESHVREKSGSSNPAADCSGAFSDDDISFLMEIYGGLDEPDGLLGLANLRKSSTLQDQLIINEKAGNWAEVLTLCEQSLQMEPDSVHRHCDVLNCLLNMCHLQAMIAHVDGLVYRIPQSKKTWCMQGVQAAWRLGRWDLMDEYLAEADKGLVCRSSENNASFDMGLAKIFNAMMKKDQFMVAEKIAQSKQALLVPLAAAGMDSYMRAYPYIVKLHMLRELEDFNSLLGDESFLEKPFAADDPKFLKLTKDWENRLRCTQPSLWAREPLLAFRRMVYNLSHMNAQAGNCWLQYARLCRLAGHYETAHRAILEADASGAPNAHMEKAKYLWNIRKSDSAIAELQQTLLNMPADVLGPTVLSSLSSLSLALPNAPLSVTQASKENPDVSKTLLLYTRWIHYTGQKQSNDIKSLYSRVADLRPKWEKGFFCIAKFYDDLLVDARRRQEDKKIASGVGPVPPSSTGSLTTATEEKPWWDMLPVVLIQYARGLHRGHKNLFQALPRLLTLWFEFGSIYIQDGSSFNKPMKEVHIRLLGIMRGCLKDLPPYQWLTVLSQLISRICHQNIEVVKLVKCIVTSILREYPQQALWMMAAVSKSTVAARRDAAAEILQSAKKGSRRGSDSNALFMQFPSLIDHLIKLCFHPGQPKARAINISTEFSSLKRMMPLGIILPIQQALTVTLPSYDTNMTDQSTFRPFSVSEHPTIAGIADDAEILNSLQKPKKVVFIGSDGISRPFLCKPKDDLRKDSRMMEFNAMINRLLSKVPESRRRKLYIRTFAVVPLTEDCGMVEWVPNTRGLRQILQDIYITCGKFDRMKTNPQIKKIYDQLQGKMPEEMLKAKILPMFPPVFHKWFLTTFSEPAAWIRARAAYAHTTAVWSMVGHIVGLGDRHGENILLDSTTGDCIHVDFSCLFDKGLLLEKPEVVPFRFTQNMVDGLGITGYEGVFVKVCEITLSVLRTHKEALMTVLETFIHDPLVEWTKSHKSSGVEVRNPHAQRAISNITERLQGVVVGVNAAPSLPLSVEGQARRLIAEAVSHSNLGKMYVWWMAWF
What is the function of this protein?
Probable serine/threonine kinase.  Seems to play a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression.  May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase ATR.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. ATM subfamily.
What are the subcellular locations of this protein?
Nucleus.