PharMolix/UniProtQA huggingface dataset:
Protein: NAC_METMA
Sequence: MFPGMGGVGGRGMNPAKMKQMMKQMGIDVKELKDVEEVVIKTADSNIVIENANVTIMTVQGSETYQIVGDVKEVPKSLEIPAEDIKLVMEQTGVSEEEARNALKNSNGDLAEAIVALSSA
What is the function of this protein?
Contacts the emerging nascent chain on the ribosome.
What are the official names of this protein?
Nascent polypeptide-associated complex protein.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: EFG_BACCQ
Sequence: MAREFSLENTRNIGIMAHIDAGKTTATERILYYTGRIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKGHRVNIIDTPGHVDFTVEVERSLRVLDGAVAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTIHDRLQANAHPIQLPIGAEDEFNGIIDLVEECAYMYGNDLGTDIQRVEIPEEHKELAEEYRGKLIEAVAELDEEMMMKYLEGEEITVEELKAGIRKATTSVEFFPVICGSAFKNKGVQILLDAVIDYLPSPLDVPAIKGTLPDTDEEVERKSSDEEPFSALAFKIMTDPYVGKLTFFRVYSGVLNSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEKSLVILESMEFPEPVISVAIEPKSKADQDKMGTALSKLSEEDPTFRAHTDQETGQTIIAGMGELHLDIIVDRMRREFKVEANVGAPQVAYRETFRSAAKVEGKFARQSGGRGQFGHVWIEFEPNEEGKGFEFENKIVGGVVPREYIPAVGAGLEDALKNGVLAGYPVVDIKAALVDGSYHDVDSSEMAFKIAASMALKAAVSKCNPVILEPMMKVEVVIPEEYMGDIMGDVTSRRGRVEGMEARGNAQVVRAMVPLSEMFGYATSLRSNTQGRGTFSMVFDHYEEVPKSVSEEIIKKNKGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBJL_SALHS
Sequence: MNINVADLLNGNYILLLFVVLALGLCLGKLRLGSVQLGNSIGVLVVSLLLGQQHFSINTDALNLGFMLFIFCVGVEAGPNFFSIFFRDGKNYLMLALVMVGSALLIALGLGKLFGWDIGLTAGMLAGSMTSTPVLVGAGDTLRHSGIASTQLSSALDNLSLGYALTYLIGLVSLIVGARYLPKLQHQDLQTSAQQIARERGLDTDANRKVYLPVIRAYRVGPELVAWTDGKNLRELGIYRQTGCYIERIRRNGILANPDGDAVLQMGDEIALVGYPDAHARLDPSFRNGKEVFDRDLLDMRIVTEEIVVKNHNAVGRRLAQLKLTDHGCFLNRVIRSQIEMPIDDNVVLNKGDVLQVSGDARRVKTIADRIGFISIHSQVTDLLAFCAFFIIGLMIGMITFQFSNFSFGIGNAAGLLFAGIMLGFLRANHPTFGYIPQGALNMVKEFGLMVFMAGVGLSAGSGISNGLGAVGGQMLIAGLVVSLVPVVICFLFGAYVLRMNRALLFGAMMGARTCAPAMEIISDTARSNIPALGYAGTYAIANVLLTLAGTLIVIIWPGLG
What are the official names of this protein?
Putative transport protein YbjL.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HTPX_ERWT9
Sequence: MMRIALFLLTNLGVMVVFGLILSLTGIQSSSVMGLMIMAGLFGFGGAFVSLLMSKWMALRSVGGEVIEQPRNETERWLLDTIAKQSQQAGIAMPQVAIYHAPDINAFATGARRDASLVAVSTGLLQNMSRDEAEAVLAHEVSHIANGDMVTMTLIQGIVNTFVIFISRILAQLAAGFMSGDREEEGNSNGNPMVYFVVSMVLELVFGIVASTITMWFSRHREFHADAGAARLAGSEKMIAALQRLKTSYEPQEASSMMALCINGKSKSISELFMSHPPLDKRIEALRSGQYAR
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PME54_ARATH
Sequence: MGVIDMVLFWVLLVNALLIVDASSRNMPFAYQNEMQRHCSSTKYTSLCVQNLREFRHGSLDGLDFVSFLVNKTISDSNLLIPPLSSSMGSSKLVSLEDSTYTLPSPSVSDSCERLMKMSTRRLRQAMEALNGSSRKRHTKHDVQTWLSAAMTFQQACKDSILDSGGSSSASAISHISQKMDHLSRLVSNSLTLVDTIMKNPKPKTKSTALPRWVTAGERRLLVGRARAHVVVAKDGSGDYRTVMEAVTAAHGNGKDLTVIVGDDSATGGTSVPDTATMTVTGDGFIARDIGIKNIAGPRGHQAIALSITSDQSVLYRCSISGYQDTLYAAALRQFYRECDIYGTIDFIFGNAAAVFQSCNIFLRRPHGVKAYNVILANGRTDQRQNTGFALHSCRIRTDSDLSPVKHKYSSYLGRPWRKYSRAIVMESYIDDAIAEGGWAGWLDSGDEVLKTLYFGEFKNYGPKARISKRVTWEGFHSIGFEEANYFSVVKRRNGEDVTNGFKYKFKIKIQI
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
What are the official names of this protein?
Probable pectinesterase/pectinesterase inhibitor 54.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: SYP_BORPA
Sequence: MRASKYHLNTLKEAPAEAEIASHQLMTRAGMIRKLAGGIYTYMPLGLKVIRKIEGIVREEMNAAGAIELLMPVVQPAELWMESGRWEQYGAELLRIKDRHQRDFVLQPTSEEVITDIARNEIQSYRQLPLNFYHIQTKFRDERRPRFGLMRGREFTMKDAYSFDRDEAGAQRSYDIMYAAYQRIFQRLSLEFRAVAADTGSIGGSRSHEFQVIADTGEDLIVYNPESDYAANIELAEAPALLAARAAPAQDLEAVPTPGAAKCEDVAKLLGLPLARTIKSIVLAVDQPEGPAQVWLLLLRGDHELNEIKAGKLPGLAGFRFATETEIVDHFGCKPGYLGPIKTARPVHVVADRTVANMADFVCGANREDYHYQGANWGRDLPEPELVADLRNVVEGDPSPDGKGALSIQRGIEVGHVFFLGTKYSEALKATFLDDNGKPAVLQMGCYGIGVTRIVGAAIEQNHDARGIIWPRAIAPYEVVICPVGWGKSETVRDTALALYEALRARGVDVMLDDRDSRPGVMFAEWELIGVPLRVTVGERGLNEGVVELQARREAEAAKVPVDQALAQTLAKLDLL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RXLRU_PHYIT
Sequence: MRAVYILAMACAATLQASSSALPSTKDLNSQVESLVPSDITDSAHVGGVRLLRVEDKEEETEEERGFGGALADGLKKLNPAKAAKKAKEKSCEN
What is the function of this protein?
Effector that enhances P. infestans colonization of Nicotiana benthamiana leaves.
What are the official names of this protein?
RxLR effector protein PITG_15972.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus.
Protein: K5_VACCW
Sequence: MTLVQHVVTIKSTYWVIPWELASYDNPNLFTAMILMSPLVNADAVSKLNLLAAKLMGTITLNAPVGKLCPESVSRDMDKVYKYQYDPLINHEKIKAGFASQVLKATNKVRKIISKINTPRLSYSREQTIRLAMF
What are the official names of this protein?
Protein K5.
What is the protein family that this protein belongs to?
Belongs to the poxviridae K5 protein family.
Protein: GCH4_ROSDO
Sequence: MNIHTPGLELTPDRDEAQAALDVLRQWAKQATPAEISELDPSVARLVPGMDGVEYPALSREYPSDFSLDDGYKETLPDLQNGPSSLIRGTKQQIQHVGISNFRLPIRFHTRSGGDITLETSVTGSVSLEADKKGINMSRIMRSFYKHAEETFSFEVIEAALDAYINDLESFDARIQMRFSFPMKVDSLRSGLSGYQYYDIALELVDQGGVRKKIMHLDYVYSSTCPCSLELSEHARATRGQLATPHSQRSVARISVEVENDGQCLWFEDLIEACRRAVPTETQVMVKREDEQAFAELNAANPIFVEDAARLFCEQLHSDTRIGDFRVIASHQESLHSHDAVSVLMEGETFKSESLDPKLFNTLFHVG
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: GPMI_YERPE
Sequence: MSSTKKPLVLTILDGYGHREEQQDNAILNAKTPVMDVLWQQQPHTLIAASGLDVGLPDGQMGNSEVGHVNLGAGRIVYQDLTRLDKEIKEGDFFTNPTLTAAVDNAVKTGKAVHIMGLLSAGGVHSHEDHIMAMVELAAKRGATAIYLHAFLDGRDTPPRSAESSLKRFTAKFAELGNGRIASIIGRYYAMDRDNRWDRVQLAYDLLTQAKGEFTADNAVAGLQAAYARGENDEFVKPTVIQATGEADAAMNEGDTLIFMNFRADRARQITRTFVNAEFDGFKRDKVVNFGDFIMLTEYAADIKVACAYPPASLTNTFGEWLMKHDKTQLRISETEKYAHVTFFYNGGVEEPFKGEDRILINSPKVATYDLQPEMSSAELTEKLVSAIGSGKYDVIICNYPNGDMVGHTGDYDAAVKAVETLDNCIEQVVAAVKAADGQLLITADHGNAEQMRDPATGQAHTAHTSLPVPLIYVGNKAVKAVEGGKLSDIAPTMLSLMEMEIPQEMTGKPLFIVE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: DBP9_KLULA
Sequence: MAQTSASQGYIDDSSSFDSFHLDSRLSQAIRSIGFKHPTLIQSSAIPLALQEKRDIIAKASTGSGKTLAYLIPVIQTILDHKKADQNDEGATLGVILVPTRELAQQVLEVVEKLIVFCSQEIKCLNLSSGNVSGNLLKSLLTENPEILIATPAKLVDLLDAQDVNIDRLKFLVIDEVDLVLTFGYQEDLTKISERLPLRKSLQTFLMSATLNDDIQHLKQQFCRSPAILKLNDDEVNKDQTKLIQYYVKVGEFDKFLLCYVIFKLGLIKGKTLIFVNNIDRGYRLKLVLEQFGIKSCILNSELPANSRQHIVEEFNKNVYQLLIATDDTEYIKEEDEDLESEKTEDGLVEVVDDSTVTTKDNAKKQKKPKLNVEKDKEYGVSRGVDFKNVACVLNFDLPTTAKSYVHRIGRTARAGKSGISISFVVPLKEFGKHKPSMIKSAKKDEKILGRIIKQQAKLGFELQPYNFDIKQVEGFRYRMEDGFRAVTQVAIREARIKELKQELLASEKLKRHFEENPHDLESLRHDKELHPARVQQHLKRVPDYLLPETARKDNKKIGFVPFHKNSHRKNGRVVKKKGNVQRKGKSDPLKSFK
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs.
What are the official names of this protein?
ATP-dependent RNA helicase DBP9.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TREZ_SACSO
Sequence: MTFAYKIDGNEVIFTLWAPYQKSVKLKVLEKGLYEMERDEKGYFTITLNNVKVRDRYKYVLDDASEIPDPASRYQPEGVHGPSQIIQESKEFNNETFLKKEDLIIYEIHVGTFTPEGTFEGVIRKLDYLKDLGITAIEIMPIAQFPGKRDWGYDGVYLYAVQNSYGGPEGFRKLVDEAHKKGLGVILDVVYNHVGPEGNYMVKLGPYFSQKYKTPWGLTFNFDDAESDEVRKFILENVEYWIKEYNVDGFRLDAVHAIIDTSPKHILEEIADVVHKYNRIVIAESDLNDPRVVNPKEKCGYNIDAQWVDDFHHSIHAYLTGERQGYYTDFGNLDDIVKSYKDVFVYDGKYSNFRRKTHGEPVGELDGCNFVVYIQNHDQVGNRGKGERIIKLVDRESYKIAAALYLLSPYIPMIFMGEEYGEENPFYFFSDFSDSKLIQGVREGRKKENGQDTDPQDESTFNASKLSWKIDEEIFSFYKILIKMRKELSIACDRRVNVVNGENWLIIKGREYFSLYVFSKSSIEVKYSGTLLLSSNNSFPQHIEEGKYEFDKGFALYKL
What are the official names of this protein?
Malto-oligosyltrehalose trehalohydrolase, MTHase, 4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase, Glycosyltrehalose trehalohydrolase, GTHase, Maltooligosyl trehalose trehalohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P53_BOSIN
Sequence: MEESQAELNVEPPLSQETFSDLWNLLPENNLLSSELSAPVDDLLPYTDVATWLDECPNEAPQMPEPSAPAAPPPATPAPATSWPLSSFVPSQKTYPGNYGFRLGFLQSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRCPHHERSSDYSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYESPEIDSECTTIHYNFMCNSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGQSCPEPPPRSTKRALPTNTSSSPQPKKKPLDGEYFTLQIRGFKRYEMFRELNDALELKDALDGREPGESRAHSSHLKSKKRPSPSCHKKPMLKREGPDSD
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: 3BHS1_MACMU
Sequence: MTGWSCLVTGAGGFLGQRIVRLLVEEKELKEIRVLDKAFRPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSTLEVAGPNSYKEIIQNGHEEEPLENTWPAPYPYSKKLAEKAVLAANGWTLKNGGTLYTCALRPMYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALRDPKKAPSVQGQFYYISDDTPHQSYDNLNYILSKEFGLCLDSRWSLPLALMYWIGFLLEVVSFLLSPVYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ
What is the function of this protein?
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis.  Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione and androstenediol to testosterone.  Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms.  Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR.  Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone.  Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity.
What are the official names of this protein?
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-HSD I, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, Delta-5-3-ketosteroid isomerase, Dihydrotestosterone oxidoreductase, Steroid Delta-isomerase.
What is the protein family that this protein belongs to?
Belongs to the 3-beta-HSD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Protein: CPD_WHEAT
Sequence: AAHGGPPFEPHATVVGAVAAAAAADVAPYTATTPYMPHVSLLYGDLTDEEK
What is the function of this protein?
Hydrolyzes ADP-ribose 1'',2''-cyclic phosphate (Appr>1) that is produced during tRNA splicing into ADP-ribose 1''-phosphate (Appr-1''p).
What are the official names of this protein?
Cyclic phosphodiesterase, CPDase.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. CPD1 family.
Protein: METN1_BACC1
Sequence: MIELKNVSKVFTTKKGNVEALKSTSLQVKKGEVFGIIGYSGAGKSTLIRCVNLLEKPTTGNIIVNSQDLTTLSAKELAKARQKIGMIFQGFNLLKTVTVYENIALPLRLAGISKVEIEKRVEKYLRIVDLFTRKDAYPSELSGGQKQRVAIARALSHEPEVLLSDEATSALDPETTDSILDLLLKINEEIGITILLITHEMNVIQRICDRVAVMEHGAVVESGTVKDIFTNPQHVTTKKFVNSAFAAKIPEDVQKELQTTGEIVTLSFIGNSSGEPALAVATKRFQVYPNILSGNITQLKHEAYGKLIIHMQGEQNEINRALSFLQEQGIIVEGGRTDHGKQVLFG
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ARGL1_HUMAN
Sequence: MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD
What is the function of this protein?
Required for the estrogen-dependent expression of ESR1 target genes.  Can act in cooperation with MED1.
What are the official names of this protein?
Arginine and glutamate-rich protein 1.
What is the protein family that this protein belongs to?
Belongs to the UPF0430 family.
What are the subcellular locations of this protein?
Nucleus. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.
Protein: RS7_LAWIP
Sequence: MPRKGPVPRREVLPDPIYNSRLASRFVNRLMYDGKKGVAEKIFYGALENLSEKTGEEPLRAFERALDNVKPQFEVKARRVGGATYQVPMEVRSDRQISLSIRWLITYARSRGEKGMVNKLAAEFLDAFNNRGGAVKKKEDTHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: IF3_EHRRW
Sequence: MKSNKFSNKNKINEMITAKKVKLVDQDSVMVGVVDIEEALSRARSVNLDLVEIVHDDEYPLCKIFDYSKYRYSHKKKISDSKKKQKTIIVKELKFKLNIGDNDYNVKLNMIRGFIERGDKVKISLKFIGREILHPEVGMEIIERLIKDTSDIAKPENLPKREGNLINMILTTK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_CLOBJ
Sequence: MKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVETYVEYGAADIGIVGKDTLMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDIVETGNTLRENGLVVVEDICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUS4_YEAST
Sequence: MNGIFAIEKPSGITSNQFMLKLQHALTKSQVFSKEIQRATAERKQQYEKQTGKKASKRKLRKVSKVKMGHGGTLDPLASGVLVIGIGAGTKKLANYLSGTVKVYESEALFGVSTTSGDVEGEILSQNSVKHLNFDDLKTVEEKFVGQLKQTPPIYAALKMDGKPLHEYAREGKPLPRAIEPRQVTIYDLKVFSDSLKRDHDYPLLRPTTEEAVDTVKNLNANMLNDVLYFSKEYTEKHGLDSEVAKVEEPFPLSEQEEQEIQKEGDSYRAPKLHFKANVSSGTYIRSLVSDIGKSMRSSCYMVKLIRLQQQDWSLEKNNVFQLTDFTERDEKVWSKVLEKVLDEGATVDVIEELKKAEKEIPADVKECIVSSDQPGDEATAETIETANAEEHSNTLKRKIEQV
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (PubMed:9358157).  Also catalyzes pseudouridylation of mRNAs with the consensus sequence 5'-GGUUCRA-3' (PubMed:25219674).
What are the official names of this protein?
tRNA pseudouridine synthase 4, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase 4, tRNA-uridine isomerase 4.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: MLP31_ARATH
Sequence: MATKMAGAAMNLAKRESSSLCGKLETDIEIKASAGKFHHMFAGRPHHVSKATPGKIQGCELHEGDWGKVGSIVFWNYVHDGEAKVAKERIEAVEPEKNLITFRVIEGDLLKEYKSFVITIQVTPKRGGPGSVVHWHVEYEKIDDKVAHPETFLDFCVEVSKEIDEHLLNEE
What are the official names of this protein?
MLP-like protein 31.
What is the protein family that this protein belongs to?
Belongs to the MLP family.
Protein: COFC_METB6
Sequence: MCPHALIPFKPAGPKSRLSGILSPEEREAFARAMLEDVIAAARDANCSPVIVATELFDSEDVQITIADKDLSGTLNEVLSQAAGPVLILMADLPLATGPAIKRVASTTSDIGIVPGRGGGTNAIFVREPAKFHVDYYGMSFLKHIRIAQEAGLSCEVIDSFLLHTDIDEEDDLVELLTHGSGKSRKYLEDLGFVLSAENGRVGVKRPVQPAPAT
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: MFF_MOUSE
Sequence: MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQEFQDGVPNASVIMQVPERIVVTGNNEDISFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPLPTPQSEESRAVGRLKRERSMSENAVRQNGQLVRNDSIVTPSPPQARVCPPHMLPEDGANLSSARGILSLIQSSTRRAYQQILDVLDENRRPVLRGGSAAATSNPHHDNVRYGISNLDAAIEGASDDMTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR
What is the function of this protein?
Plays a role in mitochondrial and peroxisomal fission (PubMed:23283981, PubMed:30059978).  Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23283981).  May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity).
What are the official names of this protein?
Mitochondrial fission factor.
What is the protein family that this protein belongs to?
Belongs to the Tango11 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Protein: NPL_XENTR
Sequence: MEFAGKRLKGLIAATFTPMTSNSDINLPVIKQYVDYLVQKQHVRNIFVNGTTGEGMSLSVQERKCLAEEWVKQARGKMDNVIIHVGCLSLSDSKDLAAHAASCGADAISIVCPSFLKPSSLDALVLYMKEVAFAAPSLPFYYYHIPRLTGTTYQICELLRKAKENIPSFRGVKFTDVNLMDFGLCVSQYKEFDCLYGVDEQLLGALAFGAHGAVGSTYNYLGKKNGDMMAAFEGGNLQEARKIQCSLQEFLLFVFDMGWGLPEFKDIMSQISGIPLGPPRLPLYSSVKSDHHDSIRTKMLKLDLI
What is the function of this protein?
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.  It prevents sialic acids from being recycled and returning to the cell surface.  Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
What are the official names of this protein?
N-acetylneuraminate lyase, NALase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialate-pyruvate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_METC4
Sequence: MKLNEIRDNEGATKARMRVGRGIGSGKGKTGGRGVKGQKARSGVSIKGFEGGQMPLHRRLPKRGFNNIHAHDLNEVNLGRVQQAVDAGKLDANAAVTVEALVKAGIISRARDGVKLLGVGELTSKLSFEVTRASKSAIEAVEKAGGSVTTTFAAGVAHRGAAEGAVASA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.