PharMolix/UniProtQA huggingface dataset:
Protein: SARCO_HUMAN
Sequence: MGINTRELFLNFTIVLITVILMWLLVRSYQY
What is the function of this protein?
Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+).  Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle.  Required for muscle-based, non-shivering thermogenesis (By similarity).
What are the official names of this protein?
Sarcolipin.
What is the protein family that this protein belongs to?
Belongs to the sarcolipin family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: MDM38_YEAST
Sequence: MLNFASRASCVTRRQASLYFVKNQGPRLIASTIPSCHWPLRAQGVQPNYPLSLRFYSTDKSKSVTKPVAPTSTDAPAKPKETLMVKVKHALKHYANGTKLLGYEIKVSTKLLIKFAQGYELSRRERNQLRRTMGDVFRLIPFSAFLIIPFAELFLPFALKLFPNLLPSTYESGKDKQAKRNKLIEIRKKTSEFLHETLEESNLITYNTIENAEKKQKFLNFFRKLYSAKEGKIMTFQHDEISAIAQMFKNDSVLDNLSRPQLAAMSKFMSLRPFGNDNMLRYQIRSKLKDIMNDDKTIDYEGVESLSQEELYQACVSRGMKAYGVSKEDLVDNLKVWLELRLRQKIPSVLMVLSSTFTFGGLPKENYSKAFSPLAEKKETKSKYDDLLDLYYDGILQVLSSIPDPVYNVAKLDVSESKSSAAETEAEKQVAEKKIKTEEKPEETAIPKEEATAKESVIATTASAVTPKLVVVNEKAETAKTEEISQEKENAEPTDSAEATEAEEKKTSDDNEFKLNVLKEQEELIKKEEEEAKQRASREHVPDDINLDEEEEAKSVPPIPADQAAKTFVIKKD
What is the function of this protein?
Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation (PubMed:11907266, PubMed:15138253).  With MBA1, plays a role in ribosomal translation and protein insertion into the inner membrane (PubMed:20427570).
What are the official names of this protein?
Mitochondrial distribution and morphology protein 38.
Protein: ISOPS_PICSI
Sequence: MALPSSSLSSRIPTGPHPLTHTQCIPHFSTTINAGISAAKPRSFYLRWGKDSQPKNLGSNKIIACVGEGTTSLPYQSAEKTDSLSAPTLVKREFPPGFWKDHVIDSLTSSHKVSAAEEKRIETLISDIKNIFRSMGYGETNPSAYDTAWVARIPAVDGSEQPEFPETLEWILQNQLKDGSWGEGFYFLAYDRILATLACMITLTLWRTGETQIRKGIEFFKTQAGKIEDEADSHRPSGFEIVFPAMLKEAKVLGLDLPYELSFIKQIIEKREAKLERLPTNILYALPTTLLYSLEGLQEIVDWQKIIKLQSKDGSFLTSPASTAAVFMRTGNKKCLEFLNFVLKKFGNHVPCHYPLDLFERLWAVDTVERLGIDRHFKEEIKDALDYVYSHWDERGIGWARENPVPDIDDTAMGLRILRLHGYNVSSDVLKTFRDENGEFFCFLGQTQRGVTDMLNVNRCSHVAFPGETIMQEAKLCTERYLRNALEDVGAFDKWALKKNIRGEVEYALKYPWHRSMPRLEARSYIEHYGPNDVWLGKTMYMMPYISNEKYLELAKLDFNHVQSLHQKELRDLRRWWKSSGFSDLKFTRERVTEIYFSAASFIFEPEFATCRYVYTKMSIFTVILDDLYDAHGTLDNLNLFSEGVKRWDLSLVDRMPQDMKICFTVLYNTVNEIAVEGRKRQGRDVLGYIRNVLEILLAAHTKEAEWSATRYVPSFDEYIENASVSISLGTVVLISALFTGEILTDDVLSKIGRGSRFLQLMDLTGRLVNDTKTYQAERGQGEVASAVQCYMKDHPEISEEEALKHVYTVMENALDELNREFVNNREVPDSCRRLVFETARIMQWFYMEGDGFTVSHEMEIKEHVKNCLFQPVA
What is the function of this protein?
Terpene synthase (TPS) involved in the biosynthesis of diterpene natural products included in conifer oleoresin secretions and volatile emissions; these compounds contribute to biotic and abiotic stress defense against herbivores and pathogens (PubMed:21385377).  Catalyzes the conversion of (+)-copalyl diphosphate ((+)-CPP) to isopimaradiene (PubMed:21385377).
What are the official names of this protein?
Isopimaradiene synthase, chloroplastic, Terpene synthase TPS-Iso, PsTPS-Iso.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EM55_PONAB
Sequence: MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASVAQSAPSEAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQDKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY
What is the function of this protein?
Essential regulator of neutrophil polarity.  Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
What are the official names of this protein?
55 kDa erythrocyte membrane protein, p55, Membrane protein, palmitoylated 1.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cell projection, stereocilium. Note=Colocalizes with WHRN at stereocilium tip during hair cell development. Colocalizes with PALS1 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies, and at connecting cilium (CC) (By similarity). Colocalizes with NF2 in non-myelin-forming Schwann cells (By similarity).
Protein: JMJC_POPEU
Sequence: IEMAEGGNDNIGNESIK
What are the official names of this protein?
Transcription factor jumonji domain-containing protein.
Protein: DEP1_FUSLA
Sequence: MFQTSRSQLLYLSALGVWGLWGYAYFNGMFTRLDTITRTLHFPDNRPLRDSYTGLGPLDKQLTLLSVFYDVLTNSLSSGPRLLFFDINYAVACTNLWTLIESRRRGVRSWFLKYPAWAMVLCNANGAAIVLPIYLYCVCRSKARLRDPVVPLHEAVALPIITVVMLLQPLLIFAPAWFGYSGSETHHALIALFQVAPVIVLGLYVGITSLLSYHFPATSLSSKEYKKWISASLILAGSVASAVHIYTLTGALFTRDSDVSLTRLFVPTGGFTDPIKTLVSNENLLAEYAALLENLHLFSQWDWIVVCLTSVVYAQLLLSRREGLKVNKPAVPYEAQEMIYLTIATVVLGPGGAGSFALAIREARI
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of depudecin, a highly oxidized eleven-carbon linear polyketide that acts as a histone deacetylase (HDAC) inhibitor and makes a small contribution to pathogenesis (PubMed:19737099, PubMed:28460114).  The reducing polyketide synthase DEP5 is the central enzyme in depudecin biosynthesis by yielding the backbone polyketide chain (PubMed:19737099).  The monooxygenases DEP2 and DEP4, as well as the uncharacterized protein DEP1, then act as tailoring enzymes to modify the intermediate polyketide chain into depudecin (PubMed:19737099).
What are the official names of this protein?
Terpene cyclase DEP1, Depudecin biosynthesis cluster protein 1.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound ascI terpene cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ACUE_ASPA1
Sequence: MAPFVPYHNSAGQSKIVKFGGLLTTEFLEPPPGRCFLFRQTYRHNVEGPIPDNLRKLINSPDRPKGPPPHFHQFQTEYFRVESGVMGINVDGQVKRVTAADGEVSVKAGSVHNFFIHPDSEESMTVYLSASDSGMDYQLDRIFFENWYGYWHDALLHDGGLDWIQFLAIQDGGDAYTPAPAWVPFRRQVGYWTCVIVGRWIGGLLGYKPFFREYTTDWDFAVAKMKGSFFQRHLVHDAYAAEKNWDAQVALEAASRPENAEFEPWVQDMSPKALVLPPVQYEKGVFVDGAARATLSGVNGHANGVNGHAGVNGHATNGTNGTTTGAEWEDVVALKKRVANGANGVNGTNGVH
What is the function of this protein?
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of aculins (PubMed:26374386).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) acuA via condensation of acetate and malonate units (PubMed:26374386).  The 6-methylsalicylic acid decarboxylase acuB then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol) (Probable).  These first reactions occur in the cytosol (By similarity).  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase acuC converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase acuD (Probable).  Gentisyl alcohol is further oxidized by the oxidoreductase acuE that probably catalyzes hydroxylation of the aromatic ring (Probable).  The aromatic system might then be opened by oxidation through a Baeyer-Villiger type of oxidation, which could be catalyzed by acuF, with the carboxylic acid at C-1 subsequently reduced to an aldehyde by acuG (Probable).  Subsequently, a hemiacetal is formed, before the dehydrogenase acuH would reduce the double bond between C-4 and C-6 (Probable).  Finally, keto-enol tautomerism results in formation of aculinic acid, which exists as two diastereomers (both R/S configurations at C-1) by non-enzymatic hemiacetal formation (Probable).  The carboxypeptidase acuI could be involved in the linking of aculinic acid to an aculene A moiety produced by the aculene biosynthesis cluster and which leads to the production of aculin A (Probable).  AcuI may also be involved in the attachment of proline to aculinic acid to form epi-aculins A and B (Probable).
What are the official names of this protein?
Oxidoreductase acuE, Aculin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the oxidoreductase OpS7 family.
Protein: IDD8_ARATH
Sequence: MTSEVLQTISSGSGFAQPQSSSTLDHDESLINPPLVKKKRNLPGNPDPEAEVIALSPTTLMATNRFLCEVCGKGFQRDQNLQLHRRGHNLPWKLKQRTSKEVRKRVYVCPEKTCVHHHSSRALGDLTGIKKHFCRKHGEKKWTCEKCAKRYAVQSDWKAHSKTCGTREYRCDCGTIFSRRDSFITHRAFCDALAEETAKINAVSHLNGLAAAGAPGSVNLNYQYLMGTFIPPLQPFVPQPQTNPNHHHQHFQPPTSSSLSLWMGQDIAPPQPQPDYDWVFGNAKAASACIDNNNTHDEQITQNANASLTTTTTLSAPSLFSSDQPQNANANSNVNMSATALLQKAAEIGATSTTTAATNDPSTFLQSFPLKSTDQTTSYDSGEKFFALFGSNNNIGLMSRSHDHQEIENARNDVTVASALDELQNYPWKRRRVDGGGEVGGGGQTRDFLGVGVQTLCHPSSINGWI
What is the function of this protein?
Transcription activator that binds to the DNA sequence 5'-CTTTTGTCC-3' (PubMed:21265895, PubMed:25929516).  Regulates photoperiodic flowering by modulating sugar transport and metabolism (PubMed:21265895, PubMed:25929516).  Regulates SUS1 and SUS4 (PubMed:21265895).  Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:25829440).  Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:25829440).
What are the official names of this protein?
Zinc finger protein NUTCRACKER, Protein indeterminate-domain 8.
Protein: EFP_ECOSM
Sequence: MATYYSNDFRAGLKIMLDGEPYAVEASEFVKPGKGQAFARVKLRRLLTGTRVEKTFKSTDSAEGADVVDMNLTYLYNDGEFWHFMNNETFEQLSADAKAIGDNAKWLLDQAECIVTLWNGQPISVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVIKVDTRSGEYVSRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGB_NOVAD
Sequence: MKPPASAIDALLDGTHADPFSLLGIHEGPDGAFARAVLPGAEEAVAWSLSGKKLGKLSRVDGRGLFEGKVKGPRQPVRYACKADGHEWLVTDPYSFGPVLGPLDDFLIAEGTHLRLFDKMGAHLIEHEGARGVHFAVWAPNARLVSVVGDFNDWDHRRHPMRRRADIGVWEIFIPDIGEHRAYKYRIVGHDGGVLPLKADPYALAAEFRPSTASLTAHPVKMDWADAAHRAHWASVDARREPMSIYEVHPGSWQKPHEEGFHTWDELADRLIPYVAEMGFTHIEFLPVSEHPYDPSWGYQTTGLYAPSARFGPPEGFARFVDGAHRAGISVLIDWVPAHFPTDEHGLVRFDGTALYEHEDPRLGFHPDWNTLIYNFGRREVVSFLVNNALFWAERYHVDGLRVDAVASMLYRDYSRKAGEWIPNAEGGRENWEAVEFLKAMNRAVYGSHAGFLTIAEESTAWPGVSKPAFDGAPRENLGFGFKWNMGFMHDTLKYMAREPIHRRYHHDEITFGLMYAFSENFVLPLSHDEVVHGKGSLLNKMSGDDWQKFANLRAYYGLMWGYPGKKLLFMGQEFAQRREWSEARALDWDLLQAPAHEGIRRWVRDLNRVYASRPALHARDCEPEGFEWLVVDDAEASIFAWLRKAPGARPVAVICNMTPQVHDHYRLPLPLDGEWREVLNSDAEDYGGSGIGNLGKVTAEQGAAFVVLPPLATLMLEFEG
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: TPS6_PHYDL
Sequence: MGIHSSAENVALENVRQSVTYHPSVWGDYFLTPASNHEESSTSEGEELQESRQEVEKLLGATHDDSLQKLELIDAIQRLGVDHHFQKEIEKSLQDIYLRCCNDKDDYDHNQTDLHTVALRFRLLRQQGYNISSETFNKFTDRNGKFEESLADDVRGMLSLYEAAHCGVQGEKILDEALVFSSSNLKSILAKNHMSNSGLTARIEEAFDTPIRKCLTNFGARKFMSMYEEDESHSEALLKFARLDFNFSQKLHQKEISDLTRWWKELDFKTKLPFARDRMVECYCWTLGIHPEPQYNLARNFLSKVIMLASVIDDIYDVRGTLDELQLFTDAIQRWDISAMEQLPPYMRVCYEALLNVYAEVEELERIDGPYRVHYAKEEMKKLARAYLEESQWLYKKYIPTFKEYMSVAIPSSGYIMVAGNCLVGLGNSLVMKDFDWVSCEPLMVKASAIIARLMDDMAGHGFEKKISAVECYTNENGASEKEAFEELEKQVSNAWKDMNQEFLHPTAVSMTVLTRVLNAARVIHLLYKDGDSYTNSKTYIKELIEAVLIQPVKI
What is the function of this protein?
Sesquiterpene synthase converting farnesyl diphosphate to beta-caryophyllene as the major product.
What are the official names of this protein?
Beta-caryophyllene synthase, Terpene synthase 6, LdTPS6.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: RAP2C_HUMAN
Sequence: MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ
What is the function of this protein?
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.  May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK.  May play a role in SRE-mediated gene transcription.
What are the official names of this protein?
Ras-related protein Rap-2c.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side.
Protein: MDH_BACTN
Sequence: MSKVTVVGAGNVGATCANVLAFNEVADEVVMLDVKEGVSEGKAMDMMQTAQLLGFDTTVVGCTNDYAQTANSDVVVITSGIPRKPGMTREELIGVNAGIVKSVAENILKYSPNAILVVISNPMDTMTYLSLKALGLPKNRIIGMGGALDSSRFKYFLSQALGCNANEVEGMVIGGHGDTTMIPLTRFATYKGMPVTNFISEEKLNEVAAATMVGGATLTKLLGTSAWYAPGAAGAFVVESILHDQKKMIPCSVYLEGEYGESDICIGVPVILGKNGIEKIVELDLNADEKAKFAASAKAVHGTNAALKEVGAL
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: YBEY_PROM5
Sequence: MYQKDNASLQIDLVFKCNDFSNLSDPFLYQPGNLIFESSFWEEVLLCWINIILSEKNTSFPNFIFDKKIFSLSLQIINNNEISSINQKWMDKSGPTDVLSFPMISDEDTTKNLNFIELGDLFISLEMAFQQSLEFDHSIKKEMLWLASHGFLHLLGWEHNDDNELDNMLNFQEYLISKLD
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSY_RICBR
Sequence: MISIFSKLKQGLSKTSGKISAGIDKIFYKKKLDAETLEELEELLISTDMGSLVAAKIIEDFKSLKFDKEVETTEIKETLANLIEQQLLESEIPFTLNENKLNVVLVCGVNGAGKTTTIGKLAAMYGMQGKKVAVAACDTFRAAAVNQLDSWVTRAKALLITGEEAADPASVAYRAVEESIKQDIDILFIDTAGRLHNKKNLMDELTKIVKVIKKVDENLPTHSVLVIDAITGQNTYNQVEHFNDATNLTGLIVTKLDGSAKAGVIVGVVQRFNLPIYFIGIGEQIEDLKIFNRHDFAKSLVGL
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).  Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
What are the official names of this protein?
Signal recognition particle receptor FtsY, SRP receptor.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. FtsY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
Protein: SEC13_RAT
Sequence: MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASGNMWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASITEGQQNEQ
What is the function of this protein?
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway.  Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex.  It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.
What are the official names of this protein?
Protein SEC13 homolog, GATOR complex protein SEC13, SEC13-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC13 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Lysosome membrane. Note=In interphase, localizes at both sides of the NPC.
Protein: PDXH_ACIBS
Sequence: MSDVIKDLSELRLSYEQGELYETQVASNPHEQFLGWFNHALAANLHEPYAMSLATASASGRPHVRTVLLRGATEAGYDFYTNYDSQKGIDLAENPYAELLFYWPSLERQVRVGGHVVKIPEQESTDYYHKRPRDSQIAAYISTPQSGKIESRELLQQRFQDLQQQVQSHEVLDKPEFWGGYRLQPDYYEFWQGRPNRLHDRLSYEKIDGQWTLHRLMP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: GLMM_ACIAD
Sequence: MSYFGTDGIRGKFGEMPITPEFALKLGFAAGKVLKRTSPINKPIVVLGKDTRLSGYILESALQAGLNAAGVYVHLLGPLPTPAIAHLTRALHADAGIVISASHNPYFDNGIKFFSGEGKKLPDSLQDEINQELEHELHIEDTANLGKSVRLIDANGRYIEFCKSTFPYHFDLRNLTIVVDCANGAAYNVGPSVFRELGAKVIALYNDPNGMNINEHCGSTHPENLQKAVVHYKADLGIAFDGDADRVILVDKFGELVDGDHILYILATQAKKKPAGIVGTVMSNMALELALAKADVPFIRAKVGDRYVLQALEENDWVTGGEPSGHILTLDKSTTGDAIIAALQVLTVMVEQNKALHELVTGFELFPQVLVNVRLDQMMDPYSVPALVSEFEQAEAQLKGRGRLLIRKSGTEPVIRVMVEGDNQKEVTDLAHRLAESVRTHAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: PCGF2_MOUSE
Sequence: MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALGDDEIVSLSIEFYEGVRDREEKKNLTENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLPTVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTAAGTTTATNGGTSNCLQTPSSTSRGRKMTVNGAPCPP
What is the function of this protein?
Transcriptional repressor (PubMed:8521824).  Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824).  Has tumor suppressor activity (PubMed:8521824).  May play a role in control of cell proliferation and/or neural cell development (Probable).  Regulates proliferation of early T progenitor cells by maintaining expression of HES1(PubMed:15728456).  Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:8625838, PubMed:15183898).  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.  Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity).
What are the official names of this protein?
Polycomb group RING finger protein 2, DNA-binding protein Mel-18, Melanoma nuclear protein 18, RING finger protein 110, Zinc finger protein 144, Zfp-144.
What are the subcellular locations of this protein?
Nucleus.
Protein: URM1_LACBS
Sequence: MSTDSNTMFLKIEFGGGLELLFSNQRSHRITIPSTVPADNNTSVTTKDAASPATRPADVTYLLHHLRDHLLKEREELFMENGTVRPGILVLINDTDWELEGEGEYLLKDGDEIVLISTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DWRF8_MAIZE
Sequence: MKREYQDAGGSGGDMGSSKDKMMAAAAGAGEQEEEDVDELLAALGYKVRSSDMADVAQKLEQLEMAMGMGGVGGAGATADDGFVSHLATDTVHYNPSDLSSWVESMLSELNAPPAPLPPATPAPRLASTSSTVTSGAAAGAGYFDLPPAVDSSSSTYALKPIPSPVAAPSADPSTDSAREPKRMRTGGGSTSSSSSSSSSMDGGRTRSSVVEAAPPATQASAAANGPAVPVVVVDTQEAGIRLVHALLACAEAVQQENFSAAEALVKQIPMLASSQGGAMRKVAAYFGEALARRVYRFRPPPDSSLLDAAFADLLHAHFYESCPYLKFAHFTANQAILEAFAGCRRVHVVDFGIKQGMQWPALLQALALRPGGPPSFRLTGVGPPQPDETDALQQVGWKLAQFAHTIRVDFQYRGLVAATLADLEPFMLQPEGDDTDDEPEVIAVNSVFELHRLLAQPGALEKVLGTVRAVRPRIVTVVEQEANHNSGTFLDRFTESLHYYSTMFDSLEGAGAGSGQSTDASPAAAGGTDQVMSEVYLGRQICNVVACEGAERTERHETLGQWRSRLGGSGFAPVHLGSNAYKQASTLLALFAGGDGYRVEEKDGCLTLGWHTRPLIATSAWRVAAAAAP
What is the function of this protein?
Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway.  Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes.  Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway.
What are the official names of this protein?
DELLA protein DWARF8, Protein dwarf-8.
What is the protein family that this protein belongs to?
Belongs to the GRAS family. DELLA subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: 6PGL_SALDC
Sequence: MKQTVYTASPESQQIHVWSLNHEGTLTLVQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRIAPDDGALTFAAESALPGSPTHISTDHHGRFVFVGSYNAGNVSVTRLQDGLPVELVDVVEGLDGCHSANITPDNRTLWVPALKQDRICLFTLSDDGHLVAQEPAEVNTVEGAGPRHMVFHPNRQYAYCVNELNSSVDVWQLKNPHGEIECVQTLDMMPADFSDTRWAADIHITPDGRHLYACDRTASLITVFSVSEDGSVLSVEGFQPTEAQPRGFNIDNSGKYLIAAGQKSHHIAVYEITGTQGLLTEKGRYAVGQGPMWVVVNAY
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.