PharMolix/UniProtQA huggingface dataset:
Protein: RDRP_TOMK1
Sequence: MAYTQTATSSALLETVRGNNTLVNDLAKRRLYDTAVDEFNARDRRPKVNFSKVVSEEQTLIATKAYPEFQITFYNTQNAVHSLAGGLRSLELEYLMMQIPYGSLTYDIGGNFASHLFKGRAYVHCCMPNLDVRDIMRHEGQKDSIELYLSRLERGNKHVPNFQKEAFDRYAEMPNEVVCHDTFQTCRHSQECYTGRVYAIALHSIYDIPADEFGAALLRKNVHVCYAAFHFSENLLLEDSHVNLDEINACFQRDGDRLTFSFASESTLNYSHSYSNILKYVCKTYFPASNREVYMKEFLVTRVNTWFCKFSRIDTFLLYKGVAHKGVDNEQFYKAMEDAWHYKKTLAMCNSERILLEDSSSVNYWFPKMRDMVIVPLFDISLETSKRTRKEVLVSKDFVYTVLNHIRTYQAKALTYSNVLSFVESIRSRVIINGVTARSEWDVDKSLLQSLSMTFFLHTKLAVLKDDLLISKFALGPKTVSQHVWDEISLAFGNAFPSIKERLINRKLIKITENALEIRVPDLYVTFHDRLVSEYKMSVDMPVLDIRKKMEETEEMYNALSELSVLKTSDKFDVDVFSQMCQSLEVDPMTAAKVIVAVMSNESGLTLTFEQPTEANVALALQDSEKASDGALVVTSRDVEEPSIRGSMARGELQLAGLSGDVPESSYTRSEEIESLEQFHMATASSLIHKQMCSIVYTGPLKVQQMKNFIDSLVASLSAAVSNLVKILKDTAAIDLETRQKFGVLDVASKRWLVKPSAKNHAWGVVETHARKYHVALLEHDEFGIITCDNWRRVAVSSESVVYSDMAKLRTLRRLLKDGEPHVSSAKVVLVDGVPGCGKTKEILSRVNFEEDLILVPGRQAAEMIRRRANASGIIVATKDNVRTVDSFLMNYGKGARCQFKRLFIDEGLMLHTGCVNFLVEMSLCDIAYVYGDTQQIPYINRVTGFPYPAHFAKLEVDEVETRRTTLRCPADVTHFLNQRYEGHVMCTSSEKKSVSQEMVSGAASINPVSKPLKGKILTFTQSDKEALLSRGYADVHTVHEVQGETYADVSLVRLTPTPVSIIARDSPHVLVSLSRHTKSLKYYTVVMDPLVSIIRDLERVSSYLLDMYKVDAGTQXQLQVDSVFKNFNLFVAAPKTGDISDMQFYYDKCLPGNSTLLNNYDAVTMKLTDISLNVKDCILDMSKSVAAPKDVKPTLIPMVRTAAEMPRQTGLLENLVAMIKRNFNSPELSGVVDIENTASLVVDKFFDSYLLKEKRKPNKNFSLFSRESLNRWIAKQEQVTIGQLADFDFVDLPAVDQYRHMIKAQPKQKLDLSIQTEYPALQTIVYHSKKINAIFGPLFSELTRQLLDSIDSSRFLFFTRKTPAQIEDFFGDLDSHVPMDVLELDVSKYDKSQNEFHCAVEYEIWRRLGLEDFLAEVWKQGHRKTTLKDYTAGIKTCLWYQRKSGDVTTFIGNTVIIASCLASMLPMEKLIKGAFCGDDSLLYFPKGCEYPDIQQAANLMWNFEAKLFKKQYGYFCGRYVIHHDRGCIVYYDPLKLISKLGAKHIKDWDHLEEFRRSLCDVAESLNNCAYYTQLDDAVGEVHKTAPPGSFVYKSLVKYLSDKVLFRSLFLDGSSC
What is the function of this protein?
Is a methyltransferase active in RNA capping and an RNA helicase.  Methyltransferase displays a cytoplasmic capping enzyme activity.  This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus.  Helicase region probably exhibits NTPase and RNA unwinding activities (Potential).  It also acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  May mediate silencing suppression through either inhibition of HEN1-mediated siRNA or siRNA demethylation (By similarity).
What are the official names of this protein?
Replicase large subunit, 183 kDa protein, RNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: SERB1_MYCTU
Sequence: MMVSSHLGSPDQAGHVDLASPADPPPPDASASHSPVDMPAPVAAAGSDRQPPIDLTAAAFFDVDNTLVQGSSAVHFGRGLAARHYFTYRDVLGFLYAQAKFQLLGKENSNDVAAGRRKALAFIEGRSVAELVALGEEIYDEIIADKIWDGTRELTQMHLDAGQQVWLITATPYELAATIARRLGLTGALGTVAESVDGIFTGRLVGEILHGTGKAHAVRSLAIREGLNLKRCTAYSDSYNDVPMLSLVGTAVAINPDARLRSLARERGWEIRDFRIARKAARIGVPSALALGAAGGALAALASRRQSR
What is the function of this protein?
Likely catalyzes the dephosphorylation of O-phospho-L-serine into L-serine.
What are the official names of this protein?
Phosphoserine phosphatase SerB1, PSP, PSPase, O-phosphoserine phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. SerB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: VA0D_SCHPO
Sequence: MDALSFNTNSGYIEALVRGYESALLEQHIYSNLSQCESLEDFRLQLSSTDYGGFLANQSKLTSSIISAKATEKLLDEFDLIRRQADETLSKFMDYITYAYMIDNIMLLLTGTVNGQDTHDLLERCHPLGWFETLPALCVATNVEELYSVVLIETPLAPYFKDCLSADDLDEQHIEIIRNTLYKAYLEDFYNFCKKIGACTADTMLPILEFEADRRAITITINSFGTELSKEERAKMYPSFGRLYPFSTSILARAENAGDVENACSLVKEYSDFFDQNSQKSLDDHFNEKEVELNKLAFLQQFHYGIVYAFLKLREQEIRNLTWIAECISQNQRDRALNIVPIL
What is the function of this protein?
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).  This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector (By similarity).  Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit d, V-ATPase subunit d, V-ATPase 39 kDa subunit, V-ATPase subunit M39, Vacuolar proton pump subunit d.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein.
Protein: MTGA_ECO81
Sequence: MSKSRLTVFSFVRRFLLRLMVVLAIFWGGGIALFSVAPVPFSAVMVERQVSAWLHGNFRYVAHSDWVSMDQISPWMGLAVIAAEDQKFPEHWGFDVASIEQALAHNERNENRIRGASTISQQTAKNLFLWDGRSWVRKGLEAGLTLGIETVWSKKRILAVYLNIAEFGDGVFGVEAAAQRYFHKPASKLTRSEAALLAAVLPNPLRFKVSAPSGYVRSRQAWILRQMYQLGGEPFMQQHQLD
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: YQBE_BACSU
Sequence: MRNQEVINKAEMTLSTLESGGIMNPTQASTFIRMVQDTPTILRDARVIQMDHDTQKIEKIGFGQRILRAAQEGVALTKDQKSVPSTSTVNLSTKEVIAEVNITYDTLENNIEKDGLQNTIMQMIAERAAVDIEELLVNGDTSSSDSYLAQLDGIRKQATSHIVDAAGEELTRQTFKRGYKAVPPKYLRIPQEFRFYTSPGIEVEWKDRVADRQTNLGDAAVQGGLSSAFGVPIKGIANLQPYTIGEGDTAADVSDIILTHPKNIILGFSRNIRIEVDKDIRRRMFIIVLTAKLDSVFEEEDAVAKIVKVKE
What is the function of this protein?
Possibly a prophage capsid protein.
What are the official names of this protein?
Putative prophage capsid protein YqbE.
What is the protein family that this protein belongs to?
Belongs to the encapsulin family. Family 3 subfamily.
Protein: CXL14_MOUSE
Sequence: MRLLAAALLLLLLALCASRVDGSKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKMVIVTTKSMSRYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE
What is the function of this protein?
Chemotactic for CESS B-cells and THP-1 monocytes, but not T-cells.
What are the official names of this protein?
C-X-C motif chemokine 14, B-cell and monocyte-activating chemokine, Chemokine BRAK, Kidney-expressed chemokine CXC, MIP-2G, Small-inducible cytokine B14.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TM177_RAT
Sequence: MAGPLWRAAVFIQRHRTSLLVGSCVGLFGVQISFHLFPDPIVQWLYQYWPQGQPAPLSPQLRSLFQEVLKDIGVPSGHCYKPFTAFTFQPVSAGFPQLPAGAVVGIPAIFLGGLVTNIDHTVVIHGQKVDWQSPAGTRLRDALTLSHDAQKFALAKEVVYLESGMAALQTLPAPVCLAGTWAISVGAKHALGLYGGPMSLRAAFNLVAIVVGYVAYAFSKDSLTVALEGWLDHRTASLSAAYVRGGVEFYEKILSGNLALRSLLGRQGEKLYTPSGNIVPRHWFRINHLPYTTRRDSLLQMWRAKVSPGHF
What is the function of this protein?
Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.
What are the official names of this protein?
Transmembrane protein 177.
What is the protein family that this protein belongs to?
Belongs to the TMEM177 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GREA_MYCLB
Sequence: MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDLRENGGYHAAREEQGQQEARIRQLQDLLNIAKVGEAPKQSGVALPGSVVKVYYNDDKSDTETFLIATRQEGVNEGKLEVYSPNSPLGGALIDAKVGETRSYTVPNGNTVQVTLISAEPYHS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RLUB_VIBPA
Sequence: MSEKLQKVLARAGHGSRREIESLIKSGRVSVNGVVAKLGERLEDESSVVRIDGHIVSAKVQEEVICRVLAYYKPEGELCTRHDPEGRRTVFDRLPKIRGSRWISVGRLDANTSGLLLFTTDGELANRLMHPSRQVEREYLVRVFGEVTEQKVRNLVKGVELEDGLARFEDVVYAGGEGMNHTFYVVINEGRNREVRRLWESQECTVSRLKRVRYGDIFLDKKLPRGGWMELDLKEVNYLRELVELRPEKETMLDLSKDNTSRKRERARSQKIRRAVKRHEERVSTSKGRSNNPARRKPKKNAGEQGARNKHR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA.
What are the official names of this protein?
Ribosomal large subunit pseudouridine synthase B, 23S rRNA pseudouridine(2605) synthase, rRNA pseudouridylate synthase B, rRNA-uridine isomerase B.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: KDSB_EDWI9
Sequence: MSFIAIIPSRYASTRLPGKPLADIAGKPMVVHVMAQAQASGAERVIVATDHPDVQHAVLQAGGEVCMTRADHNSGTERLAEVVELCGFADDDIIVNVQGDEPLIPPQIIRQVAENLARCDAGMATLAVPIHDAAEAFNPNAVKVVRDSQGYALYFSRAAIPWDRERFAVSQSQIGQTFLRHIGIYAYRAGFIRRYVNWAPSQLEQIEMLEQLRVLWYGEKIHVDVALQAPGTGVDTPEDLDCVRAILASQGQN
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EALGL_STRMK
Sequence: MRLQPLFVSLALAAPCALLPTASLSAAPAAAARQADTAPVLVTAAQWQQMASEGRRYPWFAKEQARTEATLKKMMKAGIDVPVPRDKGGGRTHEQHKRNYQALLAAGTLYRLTGDRAYVDYARDMLLQYAQLYPTLGPHPEGRGQIPGRVFWQVLNDSVWLVNAIQGYDAIRDALSAEDRNTIESKVFRPMAEFLVSEPKNYDQIHNHATWAVAATGMTGYVLRDQELVEKSLRGSQKDDKFGFLRQIDLLFSPDGYYEEGPYYQRYALAPFLLFANAIERNEPQRKIFARRDGVLLKAVDVLVQSSYGGLFFPINDAILDKGIDTEELVAGIGIAYARTGDDRLLSVAEQQKRLLLSPEGLQVAQALAANKAKPFDYHPMLLRDGPDGDRGGLAILRMNGERGQALVQKDTMQGMGHGHFDKLNWLFYDNGNPVVTDYGAARFLNVEAKRGGIYLAENRSWAKQTVAHNTLVVDEQSHFNGNWKRGEAHAPQVRFFQADADTQIASATMRDAYPGVAFTRTQALLRHPDLGLPVVLDLLQVHGDKAARYDLPLHFNGHIVTTGFEAEHFPSQRPVLGKDNGYQHLWLDARSKPGSEPRSLAWLLDGRFYTYRFGSSAPAQALLVESGANDPEFNLRREPALLQRVDGQKDVTFFSVLEPHGEYNGTAEYVHGADSRIREIVRTRGSDAEVIELRLASGARIALGVADNSATTSEHSVTVDGHVYRWNGSHARLDRSKGDGK
What is the function of this protein?
Polysaccharide lyase that catalyzes the depolymerization of alginate via a beta-elimination mechanism, cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues.  Acts specifically on alginate and each of its block structures, with highest activity toward poly-beta-D-mannuronate (poly-ManA).  Shows an exolytic mode of action, producing unsaturated monomers.  Displays a very low activity against poly-beta-D-glucuronate (poly-GlcA), and is not active on poly-alpha-D-galacturonate, hyaluronan, heparin, heparan sulfate and chondroitin sulfate.
What are the official names of this protein?
Alginate lyase, Exolytic alginate lyase, Exolytic polysaccharide lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 17 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RECR_NITSB
Sequence: MKGKLKKFYNLVEALETLPSIGKKSAGRLAFHMVLHSPMDALKLAHAIEDAVSSIHRCTQCGGLSEDELCYICSDELRDRSSLCLVESARDIYVIEESGEYHGLYFVFESLNERILANLKEMIKNNGVQEIIFAFTPSMQSDATMLYIEDQLQEFHLHFTKIAQGVPTGVHLENVDMLSLSKAISERVKI
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: SSPM_MYCPH
Sequence: MANYQNASNRNSSNKLVAPGAQAAIDQMKFEIASEFGVNLGPDNSSSRRLG
What are the official names of this protein?
Protein SspM.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta-type SASP family.
Protein: LOLA_EDWI9
Sequence: MKKLLVACCVVSGMMSASVLASPSSDLQGRLNKVNSFHASFTQTVSTADGTPVQQGEGELWVKRPNLFNWHMISPDESVLVSDGKTLWFYNPFVEQVTATWLNRATGNTPFMLITRNDASDWAQYNVTQQGNTFDLVPKSAKNNLKKFTISVMPDGTINGFSAVEQDGQRSVYTLKRQQNGAVDAAKFRFTPPPGVTLDDQRQQ
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PFLA_STAA8
Sequence: MLKGHLHSVESLGTVDGPGLRYILFTQGCLLRCLYCHNPDTWKISEPSREVTVDEMVNEILPYKPYFDASGGGVTVSGGEPLLQMPFLEKLFAELKENGVHTCLDTSAGCANDTKAFQRHFEELQKHTDLILLDIKHIDNDKHIRLTGKPNTHILNFARKLSDMKQPVWIRHVLVPGYSDDKDDLIKLGEFINSLDNVEKFEILPYHQLGVHKWKTLGIAYELEDVEAPDDEAVKAAYRYVNFKGKIPVEL
What is the function of this protein?
Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
What are the official names of this protein?
Pyruvate formate-lyase-activating enzyme, PFL-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the organic radical-activating enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2893_DECAR
Sequence: MLIFLSPAKSLDYKTPPHVATFTQPAYLKQSETLIKQLRKLSPADIANLMHLSDPLALLNFNRYAEWSLPFTPENAKQAVLAFDGDVYDGLAAKNLTADDLDFAQQQVRILSGLYGILKPLDLVQPYRLEMGTRFANKAGKDLYAFWGERLLEAINAELAGMSRPVVLNLASEEYFKAAVGRKINGEVIQPVFEDWKNGKYKIISFYAKRARGLMTRYAVVNRLSEPEGLKAFDYDGYAFVPEVSDDKSWVFRRRES
What are the official names of this protein?
UPF0246 protein Daro_2893.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: PAK2_HUMAN
Sequence: MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR
What is the function of this protein?
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:7744004, PubMed:19273597, PubMed:19923322, PubMed:9171063, PubMed:12853446, PubMed:16617111, PubMed:33693784).  Acts as downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004).  Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004).  Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004).  Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288).  Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766).  Phosphorylates many other substrates including histone H4 to promote assembly of H3. 3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829).  Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207).  Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322).  On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:9171063, PubMed:12853446, PubMed:16617111).  Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964).
What are the official names of this protein?
Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, PAK-2, p58.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
[Serine/threonine-protein kinase PAK 2]: Cytoplasm. Note=MYO18A mediates the cellular distribution of the PAK2- ARHGEF7-GIT1 complex to the inner surface of the cell membrane. SUBCELLULAR LOCATION: [PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
Protein: YRP2_SYNPY
Sequence: MTTKLLFVCLGNICRSPAAEGVFLHLIEQRQLTDQFLVDSAGTGGWHVGNPADRRMQAAARRRGI
What are the official names of this protein?
Uncharacterized protein in rpcF 3'region.
What is the protein family that this protein belongs to?
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Protein: HAND1_XENLA
Sequence: MNLIGSYQHHHHHMMPDPFIFSPGSRCHQERPYFQGWVLNPGEVSPEFPAQPPYSPEYGAVVGPSQTSGRIENLGGKLGRRKGAPPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIGYLMDVLAKDSEPGGTEAFKAEIKKVDGKRRREPQPTEGYWGAAPAGEKKLKGRTGWPQQVWALELNP
What is the function of this protein?
Plays an essential role in cardiac morphogenesis.
What are the official names of this protein?
Heart- and neural crest derivatives-expressed protein 1, Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1, eHAND.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: SEC5A_ARATH
Sequence: MSSDSNDLDEDELLQMALKEQAKRDLTYQKPPSSSARKPVANLVQQPRQQKPVAAAAAPPKKSAAAVRKPSMDEDEESEVELLSISSGDDDLEREREIGGSSGGAGRGRGSDVREKGRARKEDDGAWDGGEPDCWKRVNEAELARRVRDMRESRTAPVVQKVEGKAPAPGKKVALTSLQSLPRGMECIDPLKLGIIDNKTLRLITESSGSPSKAEKVDNTLREKLVYFSDHFDPKLFLSRIHQDTTAADLEAGALGLKSDLKGRNLQRKQLVKDNFDCFVSCKTTIDDIESKLKRIEEDPEGSGTTHLFNCMKSVTSRANLAFEPLFERQAQAEKIRSVQGMLQRFRTLFNLPSIIRSSISKGEYDLAVREYKKAKSIALPSHVNILKRVLEEVEKVMLEFKGTLYKSMEDPKIDFTSLENTVRLLLELEPESDPVWHYLNVQNHRIHGLLEKCTYDHEARVEILRNDTHEKAISDAKWQQIQQNGVSYSDTASSNENNAVQVDLQSVEFPSEEIDILKGRYIKRLTAVLVHHIPVFWKTAISIFSGKFAKSSQVTDTSANKAEEKVTEARYSTHSLEEVAGMIRKTISVYEAKVNSTFCDFDESCILRPFMSDAINEVSKACQAFEAKESTPHSAVVALRKIQAEITKIYIQRLCSWMRASTEGISKEETWIPVSILERNRSPYAISYLPLAFRSVIVSGMEQVNLMILSVKSEAAKSEDMFAQIEEIIISVRLAFLNCFLDFAAHLEQIGADLSQSTSRQDNWKNGYSDEHQEEPSANTYGSVIDPHRRLLMVLSNIGYCKDELASELYNKFKYTWLQSRDKNEDSSDLQDLIMSFSGLGEKVLEHYTFAKANLIRTAATNYLLDSGIQWGSAPQVKGIRDAAVELLHTLVAVHAEVFAGAKPLLDKILGVLIEGLIDTFLSVVEENRSSDLRSIDANGFCQLMFELEYFETVLYSYFTSAATESLKSLQGTVLEIAIESISEAVETPGHNRRPTRGSEDTVSDDKQSVSADDLLALTKQCSNELLQQELERTRVNTACFAESAPLESTPPLPKATYSSFRGSMDSPSRNYRGSQSSGSPINARPRRR
What is the function of this protein?
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion.  Involved in polarized cell growth and organ morphogenesis.  During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall.  Probable component of an exocyst subcomplex specifically involved in autophagy-related, Golgi-independent membrane traffic to the vacuole.  Regulates autophagosome formation and autophagy-related Golgi-independent import into the vacuole.
What are the official names of this protein?
Exocyst complex component SEC5A, AtSec5a, Exocyst complex component 2.
What is the protein family that this protein belongs to?
Belongs to the SEC5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted, extracellular exosome. Note=Localized to globular structures in the perinuclear region (PubMed:19895414). Shuttles from the cytoplasm to the exocyst-positive organelle (EXPO) in the presence of EXO70E2 (PubMed:24307681).
Protein: URK_BACCN
Sequence: MGTNKPVVIGIAGGSGSGKTSVTKAIFDHFQGHSILILEQDYYYKDQSHLPMEERLKTNYDHPLAFDNDLLIEHLHQLLAYKMIEKPVYDYTLHTRSEEVIPVEPKDVIILEGILVLEDPRLCELMDIKLFVDTDADLRILRRMQRDIKERGRTMDSVIEQYVNVVRPMHNQFIEPSKKFADIIIPEGGQNHVAIDIMVTKIATILEEKVNL
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECY_SHIFL
Sequence: MAKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTIIEMFNMFSGGALSRASIFALGIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYTRYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTAVVSLVTGTMFLMWLGEQITERGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERGQRRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGWNWLTTISLYLQPGQPLYVLLYASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGEQTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFYFGGTSLLIVVVVIMDFMAQVQTLMMSSQYESALKKANLKGYGR
What is the function of this protein?
The central subunit of the protein translocation channel SecYEG.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.  The plug probably moves laterally to allow the channel to open.  The ring and the pore may move independently.
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
Protein: RS10_XYLFT
Sequence: MADQKIQIRLKAFDCRLIDRSAGEIVETAKRTGAHVRGPIPLPTKIERCTILVSPHADKDARDQYETCTYKRVLYIVDPNDKTVDALMKLELAAGVDVQIKLT
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: MSCL_LIMRD
Sequence: MLKEFKTFIARGNVIDMAVGIIVGAAFTSIVKSLVNNLINPLIGLFIGRIDLSNLVLTVGDAQFKYGSFLNAVINFLIISFVVFLMVKAINTFRKKEDKKTEAPSEEVMYLKEITELLKKNKE
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CYSZ_PSEPF
Sequence: MPAPVLSGPQYLREGLKLVLSPGLRLFVLLPLAINLVLFVGLIYLAGHQFSLWVDTLMPSLPEWLSFLSYILWPLFVVLVALMVFFTFTMLANVIAAPFNGFLAEKVEVVVRGTDDFPAFSWGELIAMIPRTLAREMRKLGYFLPRAIGLFILSFIPVVNIVAAPLWLLFGVWMMAIQYIDYPADNHKLGWNEMLAWLRQKRWQSMSFGGIVYLVLLIPVVNILMMPAAVAGATLFWVRERGAENLVTQR
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.