PharMolix/UniProtQA huggingface dataset:
Protein: DER_BUCAT
Sequence: MIPIIVLIGRTNVGKSTLFNVLTKTRDALVANYPGITRDRQYGYCKLQSNKKIILIDTAGLDIKLNEIEKQAQAQTLIAIKEAHLILFLVNARDGLMPQEYEISKNIRKYQKKTILVINKIDGINEASKINEFYSLGFEKIQKISASHNQGINTLINRYLIPWISEKFKKKITENLYKDTELKKIAIKVAFIGRPNVGKSTLINGILKEERMITSNTPGTTLDSISTPIKYNYENYTLIDTAGASKKKKKINDFQRFSIIKTLQTIEKSNVILLIIDASLQTCHQDLSLADFIIHSGKGIVVVVNKCDLFNSVELKKIKELIKSKLKFLYFSKIHFISALYKKGIFQLFKSIKESYEDSKRKISTSTLIRTMHIAIKKHQPPIIKGRRIKLKYAHLGSSNPPKIIIHGNQVKYLSLPYKRYLINFFYKTLKIKGTPIQIQFKDNENPYVKNKN
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: KEFF_SHIF8
Sequence: MILIIYAHPYPHHSHANKRMLEQARTLEGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVLSHGWAYGHGGTALHGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG
What is the function of this protein?
Regulatory subunit of a potassium efflux system that confers protection against electrophiles.  Required for full activity of KefC.  Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system ancillary protein KefF, Quinone oxidoreductase KefF.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HTF4_XENLA
Sequence: RDDFSSDDMKSDDESSQKEMKSSRGRTSSINEDEDLNPEQKVEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILNLEQQVRERNLNPKAACLKRREEEKVSAVSAEPPNTHPGVHPGLTDTTNPMGHM
What is the function of this protein?
Transcriptional regulator.  Involved in the initiation of neuronal differentiation.  Activates transcription by binding to the E box-containing promoter (By similarity).
What are the official names of this protein?
Transcription factor XE1.1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOZ_ACTPJ
Sequence: MARVTVQEAADKIGNRFDLILTAARRARQLQLHVREPLVPEENDKPTVIALREIEKGLINGQIMDQLENNDAIQQEVAEQEAISFLADVQANA
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: FES_FELCA
Sequence: MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDGGGRGTGPYSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLGLLIRERQQLRKTYSEQWQQLQQELTKTHNQDIEKLKSQYRALARDSAQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHQLMLPGLLQSLQDLHQEMACILKEILQEYLEISSLVQDEVVAIHLEMAAAVARIQPEAEYQGFLRQYGSTPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELTVATQTVLSRQEAVAQLQRELQNEEQNTHPRERVQLLAKKQVLQEALQALQVALCSQAKLQAQRELLQAKLEQLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLVPEVQKPLHEQLWYHGALPRAEVAELLTHSGDFLVRESQGKQEYVLSVLWDGQPRHFIIESADNLYRLEGDGFASIPLLVDHLLRSQQPLTKKSGIVLNRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDIKAKFLQEAKILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSAIYQELQSIRKRHR
What is the function of this protein?
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading.  Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.  Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT.  Plays a role in the regulation of mast cell degranulation.  Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling.  Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR.  Phosphorylates BCR and down-regulates BCR kinase activity.  Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28 (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase Fes/Fps, Proto-oncogene c-Fes.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery (By similarity).
Protein: CUD6_SCHGR
Sequence: QKPGEAVILEQSIDNDGLGQYTFGFKTSDGLIRQEQGVVKNQGTENEALEVRGTITWLGADGKDYSINFVADENGFQPQYTQ
What is the function of this protein?
Component of the abdominal endocuticle.
What are the official names of this protein?
Endocuticle structural protein SgAbd-6.
Protein: UPPP2_STRCO
Sequence: MSWFESLVLGLVQGLTEFLPVSSSAHLRLTAAFSGWHDPGAAFTAITQIGTEAAVLIYFRKDIGRIIAAWTRSLTDKSMRHDPDARMGWLVIVGSIPIGVLGLTLKDQIEGPFRDLRITATMLIVVGVIIGIADRMAARDEKGGRHRAPQQRKELENLGVRDGLIYGLCQAAALIPGVSRSGATISGGLFMGYRREAAARYSFLLAIPAVLASGVFELKDAMESDHVSWGPTLFATVIAFATGYVVIAWFMKFISTKSFMPFVWYRIALGIVIIVLVSVGVLSPHAAESGG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 2, Bacitracin resistance protein 2, Undecaprenyl pyrophosphate phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HELS_SULIR
Sequence: MSLELEWMSIDDLKLPSNVIDIIKNRGIKKLNPPQTEAVKKGLLDGNRLLLTSPTGSGKTLIAEMGIISFLLKNGGKAIYVTPLRALTNEKYLTFKDWESIGFKVAMTSGDYDTDDAWLKNYDIIITTYEKLDSLWRHRPDWLNEANYFVLDELHYLNDPERGPVVESVTIRAKRRNLLALSATISNYKQIAKWLGAEPVATNWRPVPLMEGVMYPERKKKEYTILFRDNTTRKVHGDDAIIAYTLDSLSKNGQVLVFRNSRKMAESTALKIANYMNFVSLDEKAISEILNQLDDIEEGGSDEKELLKSLISKGVAYHHAGLSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVIIGDIYRFNRKIVGYYDEIPVMEYKQMSGRAGRPGFDQIGESIIVVRDKEDVDRVFKKYILSDVEPIESKLGSERAFYTFLLGILSAEGSLSEKQLEGFAYESLLAKSLVDVYFDRAIRWLSEHSFIREENNTFTLTNFGKRVADLYINPFTADIIRKGLEGHKASCEIAYLHLLAFTPDGPLVSVGRNEEEELIELLEDLECELLVEEPYEEDEYSLYLNALKVALIMKDWIDEVDEDTILGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDDHSDKLRILNLRVTDGVKEELLELVQIGGVGRKRARLLYNNGIKGLGDVVMNPDRVRNLLGQKLGERVVQEAARLLNRFH
What is the function of this protein?
DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
What are the official names of this protein?
ATP-dependent DNA helicase Hel308.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Hel308 subfamily.
Protein: SWRC_BACSU
Sequence: MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMPYLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDMDKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSLVSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLYTFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQVQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVKAELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTLISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKDEPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAASLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIAVLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKHVDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQDFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVADQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENKKITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKIDKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFSLPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREALLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLLIVPIVYEVLAKFRKKKPGTEEE
What is the function of this protein?
Required for self-resistance to surfactin, an antimicrobial lipopeptide surfactant produced by B. subtilis.  Also required for swarming motility.
What are the official names of this protein?
Swarming motility protein SwrC.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
Protein: DER_BRUME
Sequence: MGFTLAIVGRPNVGKSTLFNRLVGRKLALVDDLPGVTRDRRIHDAKLYDLKFQVIDTAGLEEAANDSLEARMRAQTEAAISEADAVLFVIDAKAGITPADSTFAEAVRRSGKPVVLVANKAEARGSEAGMYDAFQLGLGEPCPISAEHGQGMPDLRDAIVELLGEERVFAEERQEEAADEVFTPAAVGALVGDDIEDPDAEEIPAYDATKPLRIAIVGRPNAGKSTLINTMLGEDRLLTGPEAGITRDSISADWEWHGRKIKLFDTAGMRRKARVQEKLEKLSVADSLRAIRFAEVVIIVLDATIPFEKQDLQIADLIIREGRAPVIAFNKWDLIEDRQMVLADLYEKTARLLPQVRGLRAVPISGERGQGIDKLMENVVKTHEIWNRRISTGRLNRWLEGVIAHQPPPAVSGRRLKVKYMTQVKTRPPGFVVSCSRPDAMPQSYVRYLINGLRETFDMPGVPIRLSLRTSDNPFAGRAKKKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: DEDD_ECOLI
Sequence: MASKFQNRLVGTIVLVALGVIVLPGLLDGQKKHYQDEFAAIPLVPKAGDRDEPDMMPAATQALPTQPPEGAAEEVRAGDAAAPSLDPATIAANNTEFEPEPAPVAPPKPKPVEPPKPKVEAPPAPKPEPKPVVEEKAAPTGKAYVVQLGALKNADKVNEIVGKLRGAGYRVYTSPSTPVQGKITRILVGPDASKDKLKGSLGELKQLSGLSGVVMGYTPN
What is the function of this protein?
Non-essential cell division protein that could be required for efficient cell constriction.
What are the official names of this protein?
Cell division protein DedD.
What is the protein family that this protein belongs to?
Belongs to the DedD family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=Localizes at the septal ring.
Protein: MNME_HELMI
Sequence: MVGDTIAAVATPPGEGGIGIVRVSGPGARDVLKAVFRPRYGRGVDDWASHTLHLGTIIHPDDHRVIDEALVAWMVAPRTFTTEDVVEFHCHGGSVPVRETLGAVLRAGARLAEPGEFTRRAFLGGRLDLAQAEAIIEVIRAKTRDGLGAAVSQLEGQLSRRIRKVRDDLLALLAHLEAMIDFPEEDLPDIGSERICTDLMQIQRQIGDMLERSRTGRVLREGWRTVIVGRPNVGKSSLMNALLDEQRAIVTEIPGTTRDAIEEYIDLGGIPLRIVDTAGIRETEDVVERIGVEKTREYLEKADLALVVLDGSDSLTAEDETLLLSLAGRPAVVLVNKSDLAVRRLDEKRLRSLVGEMPIISVSAKEGWGLKELTELIRRMVYGDDGLGYAPDGGRLALVTQARHREALERSYAHLRQALDAVAHGASPDFLTIDLKAAWEALGEITGDTVGEDILDKIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_SHEHH
Sequence: MNVVQGNIESKNAKVAIVVSRFNSFVVDSLLNGAVDTLKRFGQVADENITVVKVPGAVELPLAARRVAACGKFDGIIALGAVIRGGTPHFDFVAGECNKGLAQVALEFDIPVSFGVLTTDTIEQAIERSGTKAGNKGGEAALGLLEMVNVLQALEEQL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: UL95_HHV6U
Sequence: MWVMSQVRSMEPDLTLAAVYQAAANLTEQDKEIFAEAVKTAFSVCSSAAPSARLRMIETPTQNFMFVTSVIPSGVTSGEKKTKLNIDAALDNLALSFANKKSKKMARTYLLQNVLRTQDQQVAISGKYILYTKKHIETSLMIDKTKLVKKILEYAETPNLLGYTDVRDLECLLWLVFCGPKSFCQSDSCFGYSKTGYNAAFPNLLPPYLYECGQNNGLFFGIVQAYVFSWYSDFDFSALEISERARRRIRSLLYDLKQKFAEQEVSVLSVASQMCIFCALYKQNKLSLEYVSGDLKTSVFSPIIIKDCLCAQTTISTTQMLPGTKSSAIFPVYDLRKLLGALVISEGSVKFDI
What are the official names of this protein?
Protein U67.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL95 family.
Protein: BCD2_SYNWW
Sequence: MPHNNYLYQTRDIKFQIKEWLDINKILSLDAYKDYYGADDFDAICDVNFKICRDVICPANKESDEIGMKHVGGNEKAVISPDVFKTVYNTVIEAGMGPQFGDRQVEGRMPLYWYAPILEMQTGASPAMVMLWCLTQGATTVLQYNLSKELQERFLPKMYSGEWGGSMCLTEPGAGSEVGAVSTKCFPTDTPGLWKVKGQKCFITTGDWDGVDNIIHLVLAKDPDAKPGTAGISCLVVPKFWVNEDGSMGAWNDVTTTGIEHKLGIHGSATCSLAFGENDNCYGWMIGDGPVDGRGQGMAQMFQMMNEERINTGIFSLGAFGAAYYAALEYSKARVQSKKSTDPKGPSVRIIEHEDVRRMLLLQKSVMEACRALLYSSYYYIDMSKEAATEEEREYAEDMFMIQNPLCKAYVSDMAWVMCAEAIQVHGGYGFMEEYAPASLARDCKIYTLWEGTNFIQSQDFTGRKFTMKKGEPFKKWLAEIGDFIANKKTPEFAAEFAMMEKAFAAFNSIIDMNAAWTTTNKQLKQLFATRIMHAAARVICGKLMLDQGLLAAGKLAELGDSHFDANFYKGKLASVKFYVMNVVPEIFGTEEAMKAADTSAIDCPEEAIM
What is the function of this protein?
Involved in syntrophic growth of S. wolfei with butyrate, as part of the butyrate oxidation pathway.  Catalyzes the oxidation of butanoyl-CoA to crotonyl-CoA.  Probably passes the electrons released by this reaction on to electron-transfer flavoproteins (EtfAB) to finally generate hydrogen and/or formate.
What are the official names of this protein?
Butyryl-CoA dehydrogenase Swol_2052, BCD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXD1_CHICK
Sequence: MTLSSEMSEASALAEETDIDVVGEEDDEEDEEEPQPRHRRRRRSYAEDEEEEEEEEEEDAGDLHDDALLPRSPVRAGGGGGGGGGGGGAGGGDGPGGSRPPSRGGPQKAAAAGGGGAGGGGGGGGGAGGGGGGGGGGKNSLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQQLPAPELLLRAVDPAAFLPQPPPQPPQQPPCAYGPYGCGYGLQLQPYHPHSALFAFHHPSPPPRQPPAAPAGAPAAALPPPPPPPPPPRRRAPLLPAAELARTPFGYPHPLGPALAASLHAAKPGSGAAVARSPFSIESIIGGGPGPGLGAGPAPGAGGSCASQSGAATGLSRSLGSGLAPAAALPAAPGLAARISNC
What is the function of this protein?
May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.
What are the official names of this protein?
Forkhead box protein D1, Brain factor 2, BF-2, cBF-2, HFH-BF-2, T-14-6.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACYP1_DROME
Sequence: MATHNVHSCEFEVFGRVQGVNFRRHALRKAKTLGLRGWCMNSSRGTVKGYIEGRPAEMDVMKEWLRTTGSPLSSIEKVEFSSQRERDRYGYANFHIKPDPHENRPVHEGLGSSSSHHDSN
What are the official names of this protein?
Acylphosphatase-1, Acylphosphate phosphohydrolase 1, AcPDro.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_ECO55
Sequence: MAKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLDNAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFERLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRGLDITITTTAKSDEEGRALLAAFDFPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: MTLD_SALTI
Sequence: MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGENEQVDTVSGVNAVSSIGDDVVDLIAHVDLITTAVGPVVLERIAPAIAKGLVKRKAQGVDAPLNIIACENMVRGTTQLKGHVMNALADGDKAWVEQHVGFVDSAVDRIVPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAILDEGIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLPHVNLVKGIAAAMHFRSDEDPQAQELAALITEKGPQAALAQISGLDANSDVVAEAVNAYNATK
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: DING_STAAS
Sequence: MGMATYAVVDLETTGNQLDFDDIIQIGITFVRNNQIIDTYHSMIRTNLEIPPFIQALTSIEENMLQQAPYFNQVAQEIYDKIKDCIFVAHNVDFDLNFIKKAFKDCNIQYRPKKVIDTLEIFKIAFPTDKSYQLSELAEAHGITLANAHRADEDAATTAKLMILAFEKFEKLPLDTLKQLYYLSKQLKYDLYDIFFEMVRQYDAKPLDKSYEKFEQIIYRKQVDFKKPTTNYNGSLKSLYSKAVDQLGLTYRPQQLYLAETILDQLMHSEKAMIEASLGSGKSLAYLLAALMYNIETGKHVMISTNTKLLQSQLLEKDIPAMNEALNFKINALLIKSKSDYISLGLISQILKDDTSNYEVNILKMQLLIWITETPSGDIQELNLKGGQKMYFDQKIETYVPARHDVHYYNFIKRNAQNIQIGITNHAHLIHSDVENSIYQLFDDCIVDEAHRLPDYALNQVTNELSYADIKYQLGLIGKNENEKLLKAIDQLEKQRILEKLDIAPIDIFGLKASMNEIHELNEQLFSTIFTIINDSDVYDDDIHRFHNVFTFETKDILKDLHAIIDKLNKTLEIFNGISHKTVKSLRKQLLYLKDKFKNIEQSLKAGHTSFISIKNLSQKSTIRLYVKDYAVKDVLTKQVLEKFKSLIFISGTLKFNHSFEAFKQLFNKDVHFNTFEVNTSLQSAKNTSVFIPSDVASYQYKNIDEYVASIVSYIIEYTTITSSKCLVLFTSYKMMHMVQDMLNELPEFEDYVVLTQQQNQNYKIVQQFNNFDKAILLGTSTFFEGFDFQANGIKCVMIAKLPFMNKHNAKYWLMDSEFTSTFKEYVLPDAVTRFRQGLGRLIRSENDRGIIVSFDDRLINSNYKNFFEQTLENYRQKKGDIQQFGKLLRQIQKKKK
What is the function of this protein?
3'-5' exonuclease.
What are the official names of this protein?
3'-5' exonuclease DinG.
What is the protein family that this protein belongs to?
Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily.
Protein: ENO_AGRRK
Sequence: MTAITDIIAREILDSRGNPTVEVDVYLEDGSLGRAAVPSGASTGAHEAVELRDGGKRYHGKGVEKAVEAVNTEIFDAIGGMDAENQIQIDDIMIELDGTPNKSRIGANAILGVSLAVAKAAAQSANLPLYRYVGGAHARLLPVPMMNIINGGAHADNPIDFQEFMILPIGAETFRDAVRIGSEIFHVLKKELASQGHNTNVGDEGGFAPGLSSAPAALDFIMKSIEKAGYKPGEEVALGLDCASTEFFKDGKYVLEGEGRTLEPGAMAEYLAELAAKYPIVSIEDGMAEDDWEGWKALTDLIGKKTQLVGDDLFVTNSARLRDGIRMGVANSILVKVNQIGTLTETLDAVETAHKANYTAVMSHRSGETEDSTIADLAVATNCGQIKTGSLSRSDRLAKYNQLIRIEEGLGPQAKYAGSSILRG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: VE1_HPV09
Sequence: MSDNKGTKLDPKECCSAWLSLEAECSDSSLDGDLEKLFDEGTDSDISDLIDDGDAVQGNSRELFCQQESEESEQQTQLLKRKYISPQAVLQLSPQLESISLSPQHKPKRRLFEQDSGLECSVNEAEDLSETQVEEVPANPPTTAQGTKGLGIVKDLLKHSNVKAVLMAKFKEAFGVGFAELTRQYKSNKTCCRDWVIAVYAVNDDLIESSKQLLLQHCAYIWLHYMPPMCLYLLCFNVGKSRETVCRLLSTLLQVSEVQLLSEPPKLRSVCAALFWYKGSMNPNVYAHGAYPEWILTQTLINHQSANATQFDLSTMIQFAYDHEYFDEATIAYQYAKLAETDANARAFLQSNSQARLVKECATMVRHYMRGEMKEMSMSTWIHRKLLTVESNGQWSDIVRFIRYQDINFIEFLTVFKAFLQNKPKQNCLLFHGPPDTGKSMFTMSLISVLKGKVLSFANCKSTFWLQPIADTKLALIDDVTHVCWEYIDQYLRNGLDGNYVCLDMKHRAPCQMKFPPLMLTSNIDITKDQKYKYLHSRVKSFAFNNKFPLDANHKPQFELTDQSWKSFFKRLWTQLDLSDQEDEGEDGNSQRTFQCTARDFNGPV
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RL25_CAMJJ
Sequence: MLEGIVRESIGRKAAKALKRDGYLIANIYGKGLENINAAFKVNEFIKEVRKKTTLIFDVKVGSQTLSVVVVDYQKDSVTAELKHVDLKVAQKGVISKYMVPVKITGTAIGLKNKGVLIQSKRRLKVKCAAENLPNFFELDVSKLDVGDALLVRDIVVPAGVTMIDADRVAVVGVEKAR
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: PUR7_SHEHH
Sequence: MNLADKVLVVNDNLPIRTNKPVHSGKVRSVYWLTEEDSARLIKDKGYDVPADAPLAIMVISDRISAFDCVWQGENGLNGVPGKGTALNAISNHWFKLFKDKGLADSHILDIPHPLVWIVQKARPVMIEAIARQYITGSMWRSYTKGEREFCGITIPEGLEKDQKLPELLITPSTKGVLTGLEGVPEADDVNVSRSDIERHVEGFNFTKLADIDLYEKLLKEGFDVISDALAEHDQVFVDTKFEFGYVNDAAGNEKLIYMDEVGTPDSSRIWDGSSHRDGKIIEQSKEGFRQWLLNHFPDSDILLNKNRMEERFALARDNKLPESVMMDISNTYVGIAEKVIGSKLKISENPKQEIIDILREEYQLIV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ISPF_METCA
Sequence: MFRIGQGYDAHRFKEGDHIVLCGVKIPFGRGFAAHSDGDVALHALCDALLGAAALGDIGRHFPDTDARYKGIDSRVLLREVRQRIASLGYTVGNVDVTVVAQAPRLAAHIQAMRENLAQDLEIPPDCVNVKATTTEGMGFEGRGEGISAHAVALLARR
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: RS13_FRATN
Sequence: MARIAGVNIPVHKHTVIGLTSIYGIGKTRAQQICQTCNVDPTVKIKDLSEEQVESLRTEVAKFTVEGDLRREVSMDIKRLMDLGCFRGRRHRRSLPVRGQRTKTNARTRKGPRKPIKA
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.