PharMolix/UniProtQA huggingface dataset:
Protein: COAX_BORHD
Sequence: MRILMNKFVGAVQLIIDIGNTSISFALYRLDKMQIYCKLGTKRDLSFKELYKFLKVKFDYKVDQVFVSSVVPVIDTVLINAIVSLYKVNPLFIRFDLSYDLSFNLYNNNRFVLGSDVFANLVGAIEYYNINDALVVDLGTACTIFAISRREGILGGLINGGPFTDLNALIQNAYLLNDFNLAVPKKLLGLSTIDSVNSGVIYQYKYLIEGVYHELRHNYDKEFRLIITGGNSYLVLPLISVDFIANLYLTLEGIRILGNAFKGDY
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMYD2_PIG
Sequence: MRAEGDGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEFCFARKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKRDLIQSDIAALHHFYSKHLEFPDSDSLVVLFAQVNCNGFTIEDEELSHLGSXIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLNDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSCVFEDSNVYMLHMMYQAMGVCLYMQDWEGALRYGQKIIQPYSKHYPLYSLNVASMWLKLGRLYMGLENKAAGERALRKAIAIMEVAHGKDHPYISEIKQEIESH
What is the function of this protein?
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1.  Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo.  The activity requires interaction with HSP90alpha.  Shows even higher methyltransferase activity on p53/TP53.  Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53.  Monomethylates RB1 at 'Lys-860'.
What are the official names of this protein?
N-lysine methyltransferase SMYD2, Histone methyltransferase SMYD2, SET and MYND domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: RELB_ECOLI
Sequence: MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
What is the function of this protein?
Seems to be a principal mediator of cell death in liquid media.
What are the official names of this protein?
Antitoxin RelB.
What is the protein family that this protein belongs to?
Belongs to the RelB/DinJ antitoxin family.
Protein: COBQ_PARMW
Sequence: MNRKRPLMVLGTSSGAGKSLMTAALCRVLHRRGEQPLPFKGQNMSNNAWVDADGGEMAYSQAMQAWAAGLEPCCAMNPVLLKPRGDSTSEVIHGGTSVGLARAEHYYRDWFRPGWQAIREGLQTMQQRWPNGRLVLEGAGSPVEVNLQRRDLTNLRLAQYLRANCLLVADIERGGVFAQIVGTLALLRPVERPLIKGILINRFRGRRELFDEGRSWLEQHTGVPVLGVMPWLNDLFPPEDSLDLLERKPNRGPTDLEIAVLKLPSISNFSDLDPLEAEPSLRLRWVHPGDSLGSPDAVLLPGSKQTLRDLETLRSSGLDRQLTAYATNGGSLLAICGGMQLLGQELHDPEQLEGGDGAGPWPGLGLLPLTTEFGGTKALRQREVQALWPGTTPISGFELHHGSTWASDDLQPICNEPGLGWWCATPAGGCIAGTYLHGLLDNGPWRRRWLNQLRERKGLAPLITGLPHHGEHRHQLLERLADAFEQHVDLTPLLQP
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: DNAK1_COLP3
Sequence: MTKIIGIDLGTTNSCVAVMEGGIAKIIENAEGSRTTPSIVAYANNETLAGQPAKRQSVTNSTNTLFAIKRLIGRKFDDKEVQKDIKLAPYKIVKADNGDAWVEVDGKALSPQEVSAQILRKLKKDAEAYLGETVTDAVITVPAYFNDSQRQATKDAGKIAGLNVKRIINEPTAAALAYGVDKNSNADQKVVVYDLGGGTFDLSIIEISNVDGEKQFEVLATNGDTFLGGEDFDLRLINYLADEFKKESGIDIHQDTLALQRIKEAAEKAKIELSSALQTEVNLPYVTADASGPKHLNVKVTRAKLESLVDDLVKSTIAPCEQALKDAGLSKADVSEVILVGGQTRMPKVQEAVKTFFSKEPRKDVNPDEAVAMGAAIQAGVMSGAVDDVLLLDVAPLSLGIETLGGVMTKLIEKNTTIPTRASETFSTAEDNQAAVTVHVLQGQREMATDNKSLGQFNLTDINPGPRGSVQVEVTFDIDVNGILNVSAKDKATGKEQSIKITASSGLTEDEINRMVKEAELHASEDKQKRELVDQRNQADQLIHTVQTSMTSLAQDQQTELKTLIEQLKMAVNGSDKAAIEMRQSALQEAYSKTMQTEQAQSQQAAQHQGNAANDGAKDEDIIDADFEDVSNG
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK 1, HSP70 1, Heat shock 70 kDa protein 1, Heat shock protein 70 1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PURL_BRUSU
Sequence: MTISNTRDITPELIEAHGLKPDEYQRILELIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPRVIQGPGENAGVVDIGDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNAFGVPTVGGEVNFDKRYNGNILVNAFAAGLARHDGIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELILDHVPVREENMTAYEMMLSESQERMLMVLKPEKEAEAQAIFRKWGLDFAIVGKTTDDLRFRVIHQGEEVANLPIKDLGDEAPEYDRPWMEPGKHAPLPASNVPQVEDYSAALLKLIGSPDLSSRRWVYEQYDTLIQGNSLQVPGGDAGVIRVEGHETKALAFSSDVTPRYCEADPFEGGKQAVAECWRNITATGAEPLASTDNLNFGNPEKPEIMGQLVKAIEGIGEACRALDFPIVSGNVSLYNETNGQAILPTPTIAGVGLLPDWSQMAKIGGMQDGDTLVLLGGDGTHLGQSVYLRDLFDRADGPAPFVDLALEKRNGEFVRSAIRNGQVTACHDLSDGGLAIAVAEMAIKSGKGATLDAGDGLPHALLFGEDQARYVISATPEMAKLIALNAEGAGVPFRILGTVGGDRLKISKNVDVSVADLTQAYEGWFPNFMNGELTGNN
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_RHOPT
Sequence: MPTINQLIANPRVVQKSRKKVPALQQSPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHILRGVLDTQGVKNRKQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: MTNA_MARN8
Sequence: MAGRSSNRSIGTVAMRWHGDRLELLDQRLLPAEEHWIVADGASAVAQCITDMVVRGAPAIGISAAYGVALAARHAGGGDWQAEIKQAIRVLAKSRPTAVNLFWALERMEKVFHACHSLDEATDRLAAEAVRLHEDDLAANLAMADYALEVMNPDKPIAVLTHCNTGALATGGYGTALGVIRRLHEEKLLKRVYADETRPWLQGSRLTAWELTRDHIPVTLNADGAAAAIMASGKVKWIVVGADRITANGDVANKIGTYNLAVLARHHKIGFMVVAPSSTVDMSLESGKDIPIEEREGTEVREIRGIPLAPAGVQVFNPVFDVTPASLIDAIVTEKGAVRNPNITGMRALFT
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: RIMP_LACAC
Sequence: MSKVVNLVRPVVESIIDEHGDMLVNMEYIKEKSQNYLRIYVDREPNGIDIDEIAVLSELISEKLDTLDPDPLPDPYVLELSSPGAERPIKTKADWEKALNDYIHVGLYQKIEDKKMYEGTLKSYNDDEIILEVKDKTRRKTLTVPRKLIANIRFAIEF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y011_METJA
Sequence: MIGKLKNLFKLGKGKKEEKAKKSLEGKGLIIFENTKDAMRAESILKDKYKIKVVAPPPEIREGCDLAIEYELIDEFGIKRELESNDIKPLKFISLNDYSLKPLELIKVKEVDGFILVRCGNMKITIDKEGNIVNISGGGCPDVPYLALKLKGRNIKDIKEEETPKNLGFTLCAYILNKGSSQRGHSWTIIDFEVLSI
What are the official names of this protein?
Uncharacterized protein MJ0011.
Protein: VATA_THESM
Sequence: MGKIVRVTGPLVVADEMRGSRMYEVVRVGELGLIGEIIRLEGDKAVIQVYEETAGIKPGEPVMGTGASLSVELGPGLLTSIYDGIQRPLEILRSQSGDFIGRGLTAPALSRDKKWHFTPKVKVGDKVVGGDIIGVVPETSIIEHKIMIPPEIEGEIIEIVGEGDYTIEEVIAKVKAPNGEIKEVRMYQRWPVRMKRPYKQKLPPEVPLVTGQRTIDTFFPQAKGGTAAIPGPFGSGKTVTQHQLAKWSDAEVVVYIGCGERGNEMTDVLEEFPKLKDPRTGKPLMERTVLIANTSNMPVAAREASIYTGITIAEYFRDMGYNVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLASKVAEFYERAGRVRTLGSDDRIGSVSVIGAVSPPGGDLSDPVVQNTLRVVKVFWALDADLARRRHFPAINWLTSYSLYVDSIKDWWQNNVDPEWKAMRDEAMALLQKESELEEIVRIVGPDALPEREKAILLVARMLREDYLQQDAFHEVDTYCLPKKQVTMMRVILNFYRHTMRAIDAGIPVEEIAKLPVREEIGRMKYNPNIEEIAVLMEKTKEQFEELFKKYGE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: ACSS3_HUMAN
Sequence: MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVNGKPYKITSTIEDPSIFGHVEEMLKQA
What is the function of this protein?
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429).  Propionate is the preferred substrate (PubMed:28003429).  Can utilize acetate and butyrate with a much lower affinity (By similarity).
What are the official names of this protein?
Acyl-CoA synthetase short-chain family member 3, mitochondrial, Acetate--CoA ligase 3, Acyl-CoA synthetase short-chain family member 3, Propionate--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SYL_BURCH
Sequence: MHERYVPADVEAAAQGDWRAADAYKTKEDSQKPKFYCVSMLPYPSGKLHMGHVRNYTINDVMYRYLRMNGYNTLMPMGWDAFGMPAENAAMANGVPPAKWTYDNIDYMKGQMQSMGLAIDWSREIATCKPDYYKWNQWLFLKMLEKGIAYKKTGTVNWDPVDQTVLANEQVIDGRGWRSGALVEKREIPMYYLRITQYADELLNDLDGLGWPERVKIMQQNWIGKSFGVNFGFPYELDGEQKLLRVFTTRADTIMGVTFCAIAAEHPLATRLAQDKPELLAFIEECKRGGVAEADVATMEKKGVATGFSVKHPLTGEPVEVWIGNYVLMSYGEGAVMGVPGHDERDFAFAKKYDLPIRQVIASEGQTYSLDAWQEWYGDKETAVCVNSGKYDGLRYAEAVDAVAADLKAGGFGDKQVTWRLRDWGVSRQRYWGTPIPIIHCPSCGDVPVPEQDLPVVLPEDLVPDGSGNPLAKSEAFLNCTCPKCGAAAKRETDTMDTFVDSSWYFSRYTAPDAETMVDARTDYWMPMDQYIGGIEHAILHLLYSRFWTKVMRDLGLVKFGEPAKNLLTQGMVLNETYYREDAAGKKTWYNPLDVTVTHDDKGRPVGATLNADGQPVVLGGIEKMSKSKNNGVDPQLLIDQYGADTARLFTMFAAPPEQQLEWSGAGVEGASRFLRRVWSFGYGNREALAARAGFDAATLGDADKALRREIYSVLKQADFDYQRLQYNTVVSAAMKMLNAIDGAKGATPAVLRETYGVLLRVLYPVVPHVTFELWKTLGYADEFGALLDAPWPKVDEAALEQAEIELVLQVNGKVRGALKVAKDASRDAIEAAAVADEAFAKFSDGKPAKKIVVVPGRLVNIVV
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_PSEU2
Sequence: MNRLSVPRFSVLIASLCGITLLSGCVAPTAKPNDPYYAPVLPRTPMSAAANNGAIYQAGFEQNLYGDRKAFRIGDIITITLSERMAASKAATSAMSKDSTNSIGLTSLFGSGLTTNNPIGGNDLSLNAGYNGARTTKGDGKAAQSNSLTGSVTVTVADVLPNGILAVRGEKWMTLNTGDELVRIAGLVRADDIATDNTVSSTRIADARITYSGTGAFADTSQPGWFDRFFLSPLFPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: ZRAB2_HUMAN
Sequence: MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRSSSKKK
What is the function of this protein?
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts.  May interfere with constitutive 5'-splice site selection.
What are the official names of this protein?
Zinc finger Ran-binding domain-containing protein 2, Zinc finger protein 265, Zinc finger, splicing.
What is the protein family that this protein belongs to?
Belongs to the ZRANB2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRHP_HELPJ
Sequence: MNQVELLSPAGNLKKLKIALNYGADAVYGGVSHFSLRNRAGKEFTLETFKEGIDYAHALDKKVYATINGFPFNSQLKLLEEHLYKMAELEPDAFIIAAPGVIKLASKIAPHIPVHLSTQANVLNTLDAQVFYDLGVKRIVCARELSLNDAVEIKKALPDLELEIFVHGSMCFAFSGRCLISALQKGRVPNRGSCANDCRFDYEYYVKNPDNGVMMRLVEEEGVGTHIFNAKDLNLSGHIAEILSSNAISALKIEGRTKSSYYAAQTTRIYRLAVDDFYHNTLKPSFYASELNTLKNRGFTDGYLMRRPFERLDTQNHQTAISEGDFQVNGEITEDGRFFACKFTTTTNTAYEIIAPKNAAITPIVNDIGKIYTFEKRSYLVLYKILLENNTELETIHSGNVNLVRLPAPLPAFSFLRTQVRV
What is the function of this protein?
Involved in prephenate-dependent formation of 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis.
What are the official names of this protein?
tRNA hydroxylation protein P.
What is the protein family that this protein belongs to?
Belongs to the peptidase U32 family.
Protein: ISCU_BUCAI
Sequence: MAYSKKVMDHYENPRNVGSFSSTDLNVGSGLVGAPACGDVMKLQIKVNEKGIIEDACFKTYGCGSAIASSSLVTEWVKGKSIEEAESIKNTTIVEELDLPPVKIHCSILAEDAIKAAISDYKRKKIN
What is the function of this protein?
A scaffold on which IscS assembles Fe-S clusters.  Subsequently gives the nascent cluster to other proteins.  It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).
What are the official names of this protein?
Iron-sulfur cluster assembly scaffold protein IscU, Sulfur acceptor protein IscU.
What is the protein family that this protein belongs to?
Belongs to the NifU family.
Protein: BRSK2_MOUSE
Sequence: MTSTGKDGGGAQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFINLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGEAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDQPSAQHLSDTTNCMEVMTGRLSKCGTPLSNFFDVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGGDTEYPMGKDMAKMGPPAARREQP
What is the function of this protein?
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion.  Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1.  Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'.  Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.  Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis.  Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1.  While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945).  Regulates reorganization of the actin cytoskeleton.  May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.
What are the official names of this protein?
Serine/threonine-protein kinase BRSK2, Brain-specific serine/threonine-protein kinase 2, BR serine/threonine-protein kinase 2, Serine/threonine-protein kinase SAD-A.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin (By similarity).
Protein: NIKD_ECOL5
Sequence: MPQQIELRNIALQAAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTCAATLGILPAGVRQTAGEILADGKPVSPCALRGIKIATIMQNPRSAFNPLHTMHTHARETCLALGKPADDATLTAAIEAVGLENAARVLKLYPFEMSGGMLQRMMIAMAVLCESPFIIADEPTTDLDVVAQARILDLLESIMQKQAPGMLLVTHDMGVVARLADDVAVMSHGKIVEQGDVETLFNAPKHAVTRSLVSAHLALYGMELAS
What is the function of this protein?
Part of the ABC transporter complex NikABCDE involved in nickel import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Nickel import ATP-binding protein NikD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: P5F13_XENTR
Sequence: MDQPVLYNQPAFPNFSYSPGLGQEGGNYQYLGNYNAPSYPQPFFHVPPAIKSEYGAQDEVTGGSCHAAPFDWHLYPHFQFSNQVGALSSGDPSPEGRNEEDHGSISEERSSGTPSPNSPMVPSYAQYWHHAPWQGNPTGQALGLPSRAHPDGGEKPQQSDCSPTASLESGASNTEDEEVSSALSSRAERGLCSPSPNNASFGSGNEEDGTTLEEMEEFAKELKQKRVALGYTQGDIGHALGILYGKMFSQTTICRFESLQLTFKNMCKLKPLLEQWLGEAENNDNLQEMIHKAQLEEQNRKRKMRTCFDSVLKGRLEGHFMCNQKPGARELAEIAKELGLEKDVVRVWFCNRRQKEKSKSRMSKAHEFVGGASPVPSPAEHISQDYGLAPLHPNRPPFYPPPFPRNDLFPHMVPGMSMGVLTG
What is the function of this protein?
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').  Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation.  Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes.  Binds to an octamer motif in interspersed RNA (By similarity).
What are the official names of this protein?
POU domain, class 5, transcription factor 1.3, POU class V protein oct-60.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-5 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: OTSB_MYCLE
Sequence: MPVTIDPRRHSAALFDLDAVVTDTPLDSTVTLVRQLQGIGVGTAVFSTNRNSQGVLTATGLDHLFPVHVDGLASGKVTILVAAANRLMAQPGRCVVVAVDAAGITAARYGGFALVLGLVIGEDQTGHRDTLRNSGADTVVADLGEVIVRTGDRRMSELPDALQTLGLTDDLTARQPAVFFDFDGTLSDIVDDPDSARPVPGATEALQKLATHCPVAILSGRDLADVIKRIGVPGIWYSGSHGFESTAPDGTHHQNDAAEATIPILEQAATQLRDQLGPIPGVMVEHKRFGVAVHYRNVARDRVNEVAVAVRTAGQRNALRVTTGREVIELRPDIDWDKGKTLHWVIDRLHHAGTQVGSASLMPICLGDDITDEDAFDAVRHTDVGGIPIVVRHTEDGNRATAALFTLDSPMHVSEFTERLARQLSDTQR
What is the function of this protein?
Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
What are the official names of this protein?
Trehalose-phosphate phosphatase, TPP, Trehalose-6-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the trehalose phosphatase family.
Protein: SSPO_BACC0
Sequence: MGKRKANHTISGMNAASAQGQGAGYNEEFANENLTPAERQNNKKRKKNQ
What are the official names of this protein?
Small, acid-soluble spore protein O, SASP O.
What is the protein family that this protein belongs to?
Belongs to the SspO family.
What are the subcellular locations of this protein?
Spore core.
Protein: CCD66_HUMAN
Sequence: MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLLPLAENQEESFGSSF
What is the function of this protein?
Microtubule-binding protein required for ciliogenesis (PubMed:28235840).  May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840).  Plays a role in retina morphogenesis and/or homeostasis (By similarity).
What are the official names of this protein?
Coiled-coil domain-containing protein 66.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (PubMed:28235840). Enriched in the inner segment of the photoreceptor (PubMed:19777273).
Protein: CLP_XANCP
Sequence: MSLGNTTVVTTTVRNATPSLTLDAGTIERFLAHSHRRRYPTRTDVFRPGDPAGTLYYVISGSVSIIAEEDDDRELVLGYFGSGEFVGEMGLFIESDTREVILRTRTQCELAEISYERLQQLFQTSLSPDAPRILYAIGVQLSKRLLDTTRKASRLAFLDVTDRIVRTLHDLSKEPEAMSHPQGTQLRVSRQELARLVGCSREMAGRVLKKLQADGLLHARGKTVVLYGTR
What is the function of this protein?
Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway.  It includes, among others, genes involved in extracellular polysaccharide (EPS) synthesis, flagellum synthesis, protein and fatty acid metabolism, multidrug resistance, iron uptake or genes encoding extracellular enzymes, membrane components and a few transcription factors.  Regulation can be direct or indirect, via regulation of other transcriptional regulators.  Not involved in DSF-mediated biofilm dispersal.
What are the official names of this protein?
CRP-like protein Clp, Catabolite activation-like protein, CAP-like.
What are the subcellular locations of this protein?
Cytoplasm.