PharMolix/UniProtQA huggingface dataset:
Protein: CH10_CUPMC
Sequence: MNLRPLHDRVIVKRLDNETKTASGIVIPDNAAEKPDQGEVLAIGPGKKDDKGNNIALDVKVGDRVLFGKYAGQGVKVDGQELLVMREEDIMAVVNK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_RHILO
Sequence: MAVAAKNIPAPDLVPVRRALLSVFDKTGLIDFARALAAAGVELVSTGGTAKAIAEAGLAVRDVSELTGFPEIMDGRVKTLHPSVHGALLGVRDDPEHAAAMRKYGIEPIDLLVSNLYPFEEVRRSGADYAAIVENIDIGGPAMIRASAKNHAYVAIVTDPGDYASVLNALEMNIGSLSLDFRKKLAAKAFARTATYDAAISGWFAEALEIEHPTWRAFGGRLTEVMRYGENPHQSAGFYVNGDKRPGVATARQLQGKQLSYNNINDTDAAFELAGEFDPSRSAAVAIIKHANPCGVAEGTSLKSAYAKALACDPVSAFGGIVAVNRTLDAEAAEDIVKTFTEVIIAPDATDEAAAIVAAKKNLRLLVTGGLPDPRSPGTTVKSVAGGLLVQGRDNAVVDDLELKVVTKRAPTPAEMADLKFAFRVAKHVKSNAIVYAKDGATVGIGAGQMSRVDSSRIAARKALDAAEAAGMTEPLTTGSVVASDAFFPFADGLLAAVAAGATAVIQPGGSMNDKDVIAAADEHGIAMVFTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: NCLX_RAT
Sequence: MAGRWLDPLWAPGFLCVALILETASGAGDLSTKAHGHIQFSARGVNQTAMADCRAVCSLNTSDRCDFVKRNPDCHSEGGYLDYLKGIFCYFPPNLLPLAITLYVFWLLYLFLILGVTAAKFFCPNLSAISTSLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPRTAGLAIGALFGAGVLVTTVVAGGITILRPFMAASRPFLRDITFYMVAVFLTFTALYLGRITLVWALGYLGLYVFYVVTVIICTWVYQRQRSRSLVHSISETPELLTDSEEDQMSSNTNSYDYGEEYRPLLLGEETTGQILLQALNPLDYRKWRTQSISCKLLKVAKLPVEFLLLLTVPVVDPDKDDRNWKRPLNCLQLVISPLVLVLTLQSGVYGIYEIGGLLPVWAVVVIVGTALASVTFFATSNSEPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQIVRSHASEVKLEPDGLLVWVLASALGLSLVFSLVSVPLQCFQLSKAYGLCLLLFYICFIVVVLLTEFGVIHLKAD
What is the function of this protein?
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion.  Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity).  Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses.  Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity).  Involved in B-lymphocyte chemotaxis (By similarity).  Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange.  In contrast to other members of the family its function is independent of K(+) (By similarity).
What are the official names of this protein?
Mitochondrial sodium/calcium exchanger protein, Na(+)/K(+)/Ca(2+)-exchange protein 6, Sodium/calcium exchanger protein, mitochondrial, Sodium/potassium/calcium exchanger 6, Solute carrier family 24 member 6, Solute carrier family 8 member B1.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL28_RUEPO
Sequence: MSRRCELTGKGPMTGNNVSHANNKTRRRFLPNLNDVTLQSETLGRGVKLRISAAALRSVDHRGGLDAFLAKAKDEDLSDAALKVKKEIAKAQAAA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: ERLEC_HUMAN
Sequence: MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEEEEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKNIEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFKPLTLRQLEQQEEILRVPFRRNKEEDLQSTKEERFPAIHKSIAIGSQPVLTVGTTHISKLTDDQLIKEFLSGSYCFRGGVGWWKYEFCYGKHVHQYHEDKDSGKTSVVVGTWNQEEHIEWAKKNTARAYHLQDDGTQTVRMVSHFYGNGDICDITDKPRQVTVKLKCKESDSPHAVTVYMLEPHSCQYILGVESPVICKILDTADENGLLSLPN
What is the function of this protein?
Probable lectin that binds selectively to improperly folded lumenal proteins.  May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.
What are the official names of this protein?
Endoplasmic reticulum lectin 1, ER lectin, Erlectin, XTP3-transactivated gene B protein.
Protein: CAH3_HORSE
Sequence: MAKEWGYADHNGPDHWHEFYPIAKGDNQSPIELHTKDINHDPSLKAWTASYDPGSAKTILNNGRTCRVVFDDTYDRSMLRGGPLTAPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTYGGALKQPDGIAVVGVFLKIGREKGEFQLFLDALDKIKTKGKEAPFTNFDPSCLFPTCRDYWTYRGSFTTPPCEECIVWLLLKEPITVSSDQVAKLRSLFSSAENEPPVPLVRNWRPPQPLKGRVVRASFK
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 3, Carbonate dehydratase III, Carbonic anhydrase III, CA-III.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_STRT1
Sequence: MKEIFLQISNRQDLSQDQVQAVFDRILKNEVSESQIASFLMGLKIKGETSDEITGIVRALKSHATVLPETFTDAMCNCGTGGDQSYSFNISTTACFVLAAGGIRMAKAGNRSISSKSGSADVLEVLGINVAASPEILSKALDEVGLAFIFAQTMHPAMRFIGPARQALGIPTIMNLVGPLANPLDLETQLMGLYRVELQEIVANTIQQLGRKRAVIITGPDNMDEAALYGTNTYTLLEDGHISQHTFTYEDLGMEKVELSDITGGDAKENAEILLSVLRNEASPYLETTVLNVGLGFFANGKAGTIKEGVELARQLIADGSALEKLRKLQEVQV
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: IF2C_PHAVU
Sequence: MLILVGSKQGTMSSLASPVSLGSLMGVSSSGRSHSGVRRVSFSRGNCKGRKRWHCLSLSVCRYSVTTTDFIADQGNSVSLDSNSNSSSSSKSGGDDGTGFVLKPPPKPVLKAPDNRMTHLGPSRTTGDVEERNKVIESLGEVLEKAEKLGSSKVNGDKNNGSVNKPVRNNANASPRTERPVNSAASLKSKTLKSVWRKGDSVASVQKVVKEVPKPSYNKNEEEKSQTRGGEKVVSQTRAPQPPSKPQPLKPQQPSKPQPALLSKPSIAPPPVKKPVVLRDKGAAETSVKSKEKKSPILIDKFASKKPVVDPLIAQAVLAPPKPGKAPSPGKFKDDFRKKGALAGGGRRRRILDDEDVIQDASELNVSIPGAATARKGRKWSKASRKAARLQAARDAAPVKVEILEVGDSGMLVEELAYCLATSEGEILGYLYSKGIKPDGVQTIDKDMVKMICKEYDVEVIDADPVKVEGLVKKREILDEDDLDKLKDRPPVITIMGHVDHGKTTLLDYIRKSKVAASEAGGITQGIGAYKVQVPFDGKTLPCVFLDTPGHEAFGAMRARGASVTDIAVIVVAADDGIRSQTNEAIAHAKAAGVPIVIAINKIDKDGANPERVMQELSSIGLMPEDWGGNTPMVPISALKGKNVDDLLETVMLVAELQELKANPDRSAKGTVIEAGLDKSKGPLATFIVQNGSLRRGDIVVCWRSFWKGRALFDDGGKRVDEATPSIPVQVIGLNNVPIAGDVFEVVESLDAARERAETRAESLRNERISAKAGDGKITLSSLASAVSSGKLSGLDLHQLNIILKVDLQGSIEAVRKALQVLPQENVTLKFLLEATGDVNTSDVDLAVASKAIIMGFNAXTPGSVKSYADNKAVEIRLYRVIYELIDDVRKAMEGLLEPVEEQLTIGSAVVRAVFSSGSGRVAGCMVTEGKVLKDCGIRVKRKGKIVHVGIIDSLRRVKEIVKEVNAGLECGLGLEDFDDWEEGDIIEPSTQLRRRGPLKRPQHQWQLLWRE
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2, chloroplastic, PvIF2cp.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RPOC2_PROM4
Sequence: MTSTSPKSRRSSGKGRKGSKKKGKQVSQIPPLSKTPPSFRNRIVDKKALKQLVAWAYKNHGTAVTAAMADNLKDLGFKYATQAAVSISVDDLKVPDAKQDLLGEAEQQITATEECYRLGEITEVERHTKVIDTWTETNERLVDAVKKNFNQNDPLNSVWMMANSGARGNMSQVRQLVGMRGLMANPQGEIIDLPIRTNFREGLTVTEYVISSYGARKGLVDTALRTADSGYLTRRLVDVAQDVIVREEDCGTSRAILVKAEDGRFGNRLVGRLTAEQIVGDADEIIAKKDTAIDPELSKKIEKAGLAGIMVRSPLTCEATRSVCRKCYGWALAHNNLVDLGEAVGIIAAQSIGEPGTQLTMRTFHTGGVSTAETGVVRSTIAGKVEFGPNARVRGYRTPHGVEAQQAEVDFTLKVKPTGSGKTQTIEISNGSLIFVDNAQEIAADVTVAQITAGAVKKSVEKATKDVICDLAGQVRYESVIQPREVTDRQGNITLKAQRLGRLWVLAGDVYNLPPNARPVVKANSKVSKGMVLAEASQASEFGGEVRLRDSIGDSREVQIVTTSMTLKDFKLLEESTHTGEIWNLEAKDGTRYRLNSIPGSKISSGEIVAELADDRFRTKTGGLVKYAPGLAIKKARSAKNGFEVSNGGTLIWVPQETHEINKDISLLMIKDRQWIEAGTEVVKDIFSQTAGIVTVTQKNDILREIIVRSGEFHLCNESKVLERFEDEGQMVNPGENIAKGLKADSMVLVQTVESRDGKGLLLRPVEEYTIPDQAQLPELSHVKQEKGPSLGLRATQRLAFKDGELIKSVEGVELLKTQLILDTFETTPQMTVDVEVALDKRAKTINRLRLVILESILVRRDTMSDSSHGSTHTELQIKDNQLVNADDVVATTQILCKEDGIVQLPNAVDDEPIRRLIVERAQDTTVLTAKDNPILKVGERVVDGDLLSKGEPINCCGEVEDIKGNKVTLRLGRPYMVSPDSVLHVRDGDLVQRGDGLALLVFERQKTGDIVQGLPRIEELLEARRPRESAILCKKPGIVEIKQEEDDESVVVKVIESDDSLSEYSILLGRNVMVSDGQEVHAGEFLTDGPVNPHELLECFFGDLRDRKPLLEAAQESIAKLQHRLVTEVQNVYKSQGVSIDDKHIEVIVRQMTSKVRIEDAGDTTLLPGELIEIRQVEDTNQAISVTGGAPAEFTPVLLGITKASLNTDSFISAASFQETTRVLTEAAIEGKSDWLRGLKENVIIGRLIPAGTGFSGFVEELRAEAGPHPDILAEDPAGYRRMQNLRPDYTVEMPVSTAAKSTSVLDDPSEEDLEATRSRHGIDPTTSNFAAFARPSGDDPSQEDQKPDPIALEGLQEEGLLADE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
Protein: ATG3_ASPFU
Sequence: MNILHSTLSTWRDRLAPVSRTSTFRTTGQITPEEFVLAGDYLVYKFPTWSWADASSPAKRVSYLPPGKQFLVTRGVPCHRRLNENFAGDAGHEDEIVRDMLSGADADDDDGWLRTGGGRDLAEKQAERIKDVRTVDESGNMGEQEDDEEDIPDMEDDDDDEEAIIREPAGKSTTQPTRTYNLYITYSNFYRTPRLYLSGYLSPSEPLPPHLMMEDIVGDYKDKTVTLEDFPWFDGGVKMASVHPCRHASVMKTLLDRADAALKIRRDKLKQAHSADQANRINSERGLEGLVDETRGLSLNEQQGHAAGGDEWEVLQHDEEDQVAIRVDQYLVVFLKFIASVTPGIEHDFTMGV
What is the function of this protein?
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8.  The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE).  This step is required for the membrane association of atg8.  The formation of the atg8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).  The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 3, Autophagy-related E2-like conjugation enzyme atg3.
What is the protein family that this protein belongs to?
Belongs to the ATG3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_SHESR
Sequence: MGPTASGKTALALELAEKHNCEIISVDSALIYRGMDIGSAKPSAEELARGPHRLIDIRDPAESYSAADFRADALREIEQIISMGKTPVLVGGTMMYFKALLEGLSPLPSADEAIRAEIQAEADANGWEALHAQLREIDPVSAERIHPNDPQRLSRAIEVYRISGKSLTELTQTKSAPLPYDVVQFAIAPRERKVLHELIGQRFRIMLEQGFIDEVAQLKARGDLHLDLPSMRCVGYRQCWQYLDGEFDYDTMVEKAVAATRQLAKRQLTWLRSWPELNWLESGAEGNLVTLMRQCR
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: PAND_SACD2
Sequence: MQITLLKGKLHMAKVTQAELWYDGSCAIDEEFVKLAGLREFEQIEIYNVDNGERFSTYVILAEAGSRTISMNGAAARKVQVGDRVIIAAYSQMSEAEADSFKPRLVYLDKDNAVERTTNTIPVQAA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHI5_ARATH
Sequence: MLTPTISKSISLVTILLVLQAFSNTTKAQNCGCSSELCCSQFGFCGNTSDYCGVGCQQGPCFAPPPANGVSVAEIVTQEFFNGIISQAASSCAGNRFYSRGAFLEALDSYSRFGRVGSTDDSRREIAAFFAHVTHETGHFCYIEEIDGASKDYCDENATQYPCNPNKGYYGRGPIQLSWNFNYGPAGTAIGFDGLNAPETVATDPVISFKTALWYWTNRVQPVISQGFGATIRAINGALECDGANTATVQARVRYYTDYCRQLGVDPGNNLTC
What is the function of this protein?
Probably involved in hypersensitive reaction upon Xanthomonas campestris infection.
What are the official names of this protein?
Endochitinase EP3, Chitinase class IV, AtchitIV, Protein HOMOLOG OF CARROT EP3-3 CHITINASE, AtEP3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
Protein: CITE1_MOUSE
Sequence: MPTMSRPALDVKGGTTSGKEDANQEMNSLAYSNLGVKDRKAVTVLHYPGVTANGAKANGVPTSSSGSTSPIGSPTATPSSKPPSFNLHPTPHLMASMQLQKLNSQYQGAAATAAAALTGAGLPGEEEPMQNWVTAPLVVGGSPGSVSPPAGAQSPALIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGC
What is the function of this protein?
Transcriptional coactivator of the p300/CBP-mediated transcription complex.  Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex.  Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300.  Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex.  Induces transcription from estrogen-responsive promoters and protection against cell death.  Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter.  Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling.  May play a role in pigmentation of melanocytes.  Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
What are the official names of this protein?
Cbp/p300-interacting transactivator 1, Melanocyte-specific protein 1.
What is the protein family that this protein belongs to?
Belongs to the CITED family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal (NES) and in a CRM1-dependent manner.
Protein: YVBF_VACCC
Sequence: MVIIPGVRCLSLLFLRRRCPLHIISAFTLLAINALILGHTISPVDLSFTICGYEIKSIFDSETDTIVKFNDIMSQ
What are the official names of this protein?
Uncharacterized 8.4 kDa protein.
Protein: Y562_CLOBB
Sequence: MENSLKIKDIPKKERPKEKLLSYGADTLNNSELLAIILRTGTKGENVLQLSNRLLSKFQGLDGVLEASLDDITSIKGIKEGKASQILALAELFKRFRTFKSADRDIKIMSPNDLAMLINGEMSLLKQEILKVIFLNTKNIVIGTKDVFKGSLNTSIVHPREIFKEAVNKSSAKIIISHNHPSGDPTPSKEDINITLRIKECGEIMGIQLLDHIIIGKNGFISLKEKGFI
What are the official names of this protein?
UPF0758 protein CLL_A0562.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: PLR_SINHE
Sequence: MAKSRVLIVGGTGYLGRRMVKACLDQGHTTYVLHRQEVGVDIDKIQMLLSFKEQGAHLVEGSFNDHRSLVEAVKLVDVVICTISGVHIRSHQILLQLKLVEAIEEAGNVKRFLPSEFGMDPARMAHAMEPGRATFDEKMVVRKAIEDAKIPHTYASANCFAGYFLGGLCQFGKIIPSKESVILSGDGNVKGIYVDEYDIATYTIKTMDDPRTLNKTIYIRPPANILSQREVVEIWEKLIGKVLDKSSLSEEDFLALMKGLSHGHQAGLTHYYHVSYEGCLTNFEVEDGVDASKLYPQVNYTTVSEYLKRYL
What is the function of this protein?
Reductase involved in lignan biosynthesis (PubMed:26359402).  Also involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family (PubMed:26359402).  Catalyzes the enantioselective sequential conversion of (+)-pinoresinol into (+)-lariciresinol and of (+)-lariciresinol into (-)-secoisolariciresinol (PubMed:26359402).  Abstracts the 4R-hydride from the NADPH cofactor during catalysis (PubMed:26359402).
What are the official names of this protein?
Bifunctional pinoresinol-lariciresinol reductase, PhPLR, (+)-lariciresinol reductase, (+)-pinoresinol reductase.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: VATE_STAMF
Sequence: MNTHEVEELRQKLLEDARKKSEEIIREAEREAERIIEEAERKWREKAEQEREKIITNARLEAQKIISEARRNYRITISKAKAEVINKILEEAKIRLTNRIGFDIEESLKKLLDEALYYIENPSKIIINPRDRDFIKKVLKEKGLKNIEIVESDNILGGLIIESIDGERVDNSYNTRLERAKSIVLAELNIILWGK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit E, V-ATPase subunit E.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase E subunit family.
Protein: GCS2_LARHH
Sequence: MLDFCASQPLTLGVELELMIVNRHDYNLTRGSDDLLRLIGREDHGFDIKPEITQGMIEIGTAIHTRTRAMLEELDAIRAVLVRAADTLNLGLAGGGAHPFQHWSEQRIYPKERYLLVSELYGYLAQQFTVYGQHIHIGCPDGDQAIRLAHFLARYIPHFIALSAASPYYQGVDTLFQSSRLTSVNAFPLSGTLPCVTDWAGFNDYFVRMQQLGIVASMKDFYWDVRPKPEYGTVEIRVCDTPLDLLTPVLLAAYAQMLARECMESGWQAIHSDNYLAYSYNRFQACRFGFEGLILNPADNGQVSLQQDLVTTLTRLEPQAAALGCEAERQQLLARALARDNPSRQLRTLYERSGSLNDLVRRQSAVWMRDAATL
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: NACA_ASHGO
Sequence: MSEIPENSKVSIYSKNEKKARELIQKFSMKPMPGITRVTFRKKNNQIFAIDNPDVYKTQGGNYVVFGEPKVDDFTRRLARAQQQAASAAKDPQSIQADMAAAAAAPAAPAAPAAAPEEDEAGQVDESGLDGQDIELVMQQANVSRNKAVKALREHNSDIVNAIMSLSK
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  EGD2 may also be involved in transcription regulation (By similarity).
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: OBG_NAUPA
Sequence: MFVDNIKLKVKSGKGGQGCVSFRREKFVVKGGPDGGDGGKGGDVIVECDKNTHTLSHYKGRKLLKAKNGRPGEGRKKHGANGEDLILKVPPGTVIKNAETGEVLLDMKEDGERKVLLEGGRGGLGNWHFRGPRNQTPRYAQPGEEGQELEIVLELKLIADVGLVGFPNAGKSTLISTLSNARPEIANYEFTTLTPKLGVVRVDEYRSFVMADIPGIIEGAHEGKGLGIEFLKHIERTSTILYMIDLSSYRDPVYQFKTLQKELKEYSEKLASRDYAIALTKCDSVEVEKIEEFFEKLGISKTEPKFKADPNLPCHFDDKTFVLPISSVANINIEALKFALFDLVEKNKRKENEENSF
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR5B2_HUMAN
Sequence: MENCTEVTKFILLGLTSVPELQIPLFILFTFIYLLTLCGNLGMMLLILMDSCLHTPMYFFLSNLSLVDFGYSSAVTPKVMAGFLRGDKVISYNACAVQMFFFVALATVENYLLASMAYDRYAAVCKPLHYTTTMTASVGACLALGSYVCGFLNASFHIGGIFSLSFCKSNLVHHFFCDVPAVMALSCSDKHTSEVILVFMSSFNIFFVLLVIFISYLFIFITILKMHSAKGHQKALSTCASHFTAVSVFYGTVIFIYLQPSSSHSMDTDKMASVFYAMIIPMLNPVVYSLRNREVQNAFKKVLRRQKFL
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 5B2, OST073, Olfactory receptor OR11-240.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TYDP2_BOVIN
Sequence: MERNSGPEAGPEAELEEGEPEVKKRKLMCVEFASVASCDAAVAQCYLAENDWEMERALNSYFEPAVEESASESRPESLSEPGSCVDLTKEETNDSISSKTSTSEDKSVQQEDGSVFSFITWNIDGLDMNNLLERARGVCSYLTLYSPDVIFLQEVIPPYYAYLKKKASSYKIITGREEGYFTAIMLKKSRVKFKSQEIIPFPNTQMMRNLLCVHVSVSGNELCLMTSHLESTRGHAKERMNQFKMVLEKMQEAPGSATVIFAGDTNLRDQEVTKCGGLPNNILDVWEFLGKPKHCQYTWDTQMNSNLGIAANCKLRFDRIFFRAAAEGGHIIPQSLDLLGLEKLDCGRFPSDHWGLLCTLDVIL
What is the function of this protein?
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate.  Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue.  The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation.  Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2.  Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals.  Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate.  Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1.  Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells.  Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation.  Involved in non-canonical TGF-beta induced signaling routes.  May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.  Acts as a regulator of ribosome biogenesis following stress.
What are the official names of this protein?
Tyrosyl-DNA phosphodiesterase 2, Tyr-DNA phosphodiesterase 2, 5'-tyrosyl-DNA phosphodiesterase, 5'-Tyr-DNA phosphodiesterase, TRAF and TNF receptor-associated protein.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein.