PharMolix/UniProtQA huggingface dataset:
Protein: CH60_PELPD
Sequence: MAAKIIKFDQEGRNAILKGVNILADTVKVTLGPKGRNVVIDKSFGAPLITKDGVTVAKEIELEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGSKLVAAGHNPMEIKRGIDKAVETIVAELQKISKPIVDHKEIAQVGTISANNDKTIGDIIAEAMEKVGKEGVITVEEAKSMDTTLETVEGMQFDRGYLSPYFVTDPERMEAALENALILIHDKKISNMKDLLPILEQTAKSGRPLLIIAEDIEGEALATLVVNKLRGVLNVAAVKAPGFGDRRKAMLEDIATLTGGLVISEEVGHKLEQATMDMLGRAKRITIDKDNTTIIDGEGKEADIQGRVKQIRAQIEETTSDYDKEKLQERLAKLVGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVDEGVVPGGGVAYIRTLSALDNLNLENEQQFGVTVVKLALEAPIRQIADNAGIDASIVVDKVRNGKDAFGYDAASDEYVDMLKAGIIDPTKVSRSALQNASSIAGLMLTTEALIAEKPREEGAMGGGMPGGMGGMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HPRT_METRM
Sequence: MLENLVESLRNAPVVKKGDYDYFVHGISDGIPALNPCVLKEISEVLAERIDLDKVDKIVGVEAMGIHIATALSLETGLPLLVIRKREYGLEGEHEILKHTGYATSKLYINDLNEGDNIVLVDDVVSTGGTLSVVINELKAIGVNILDTFVVVEKGEGKKIVEDKTGENIVTLVKLDVVDGKVVADSLI
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
What are the official names of this protein?
Hypoxanthine/guanine phosphoribosyltransferase, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_WOLSU
Sequence: MSRLNIEQVYKEAQALLEGHFLLSSGNHSNFYLQSAKVLENPKVAESLAKALAEEIRAFGLTIDTVCSPALGGVLAGYELARALGVRFIFTERVEGKMTLRRGFEVASGEKILICEDIITTGGSAVESAMEVERLGAQVVGYAALANRGFCQRVGSSLERKPNAKLPPHLPFFALDDFVFDLYSPQDCPLCKTGSKPIKPGSRGN
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: SYD_STRPJ
Sequence: MKRSMYAGRVREEHIGQEITLKGWVGRRRDLGGLIFIDLRDREGIMQLVINPEKVSAEVMATAESLRSEFVIEVTGQVAAREQANDKLPTGAVELNVTALIVLNTAKTTPFEIKDGIEANDDTRLRYRYLDLRRPEMLENLKLRAKVTHSIRNYLDELEFIDVETPFLSKSTPEGARDYLVPSRVNKGHFYALPQSPQITKQLLMNAGFDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLTEQEIQDITEGLIARVMKETKGIEVTLPFPRMKYDDAMALYGSDKPDTRFDMLLQDLTEVVKGVDFKVFSEAPAVKAIVVKGAADNYSRKDIDKMTEVAKQYGAKGLAWVKVVDGELNGPVAKFLTGIQEELTTALALEDKDLVLFVADTLEVANATLGALRGRIAKELGLIDNDKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPQEETAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKDLQERMFKALGFSTEEANDQFGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGEENIREVIAFPKNNKATDPMTQAPSTVALKQLEELSLQVEEDETNKTN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_MOOTA
Sequence: MARLKEKYLQEIRKALQAKFGYKNIMEIPKLEKIVINMGVSEATQNPKAIDNAVQDLMTITGQKPVVTKAKKSIAAFKLRQGTSIGCKVTLRGDRMYEFLDRLINVALPRVRDFHGVSPNSFDGRGNYTLGIREQLIFPEIEYDKIDKVRGMDIVMVTTAKSDEEARELLRGFGMPFREH
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: LPXD_MANSM
Sequence: MSVYSLKELAEHIGATSRGNTDVVVDSIAPLDKAQANQLTFISNAKFRPFLAQSQAGILVVSEADIEFCSANSNLLITKNPYVAYALLAQYMDTTPKAASDIASTAVIASSAKLGTNVSIGANAVIEDGVELGDNVVIGAGCFIGKNTKIGANTQLWANVSIYHEVQIGSDCLIQSGAVIGGDGFGYANERGQWIKIPQTGSVIIGNHVEIGACTCIDRGALDSTVIEDNVIIDNLCQIAHNVHIGTGTAVAGGVIMAGSLTVGRYCQIGGASVINGHMEICDQAIVTGMSMILRPITEPGIYSSGIPAQTNKEWRKTAALTLDIDKMNKRLKALEKKLAD
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: CH60_NEIGO
Sequence: MAAKDVQFGNEVRQKMVNGVNILANAVRVTLGPKGRNVVVDRAFGGPHITKDGVTVAKEIELKDKFENMGAQMVKEVASKTNDVAGDGTTTATVLAQSIVAEGIKAVTAGMNPTDLKRGIDKAVAALVEELKNIAKPCDTSKEIAQVGSISANSDEQVGAIIAEAMEKVGKEGVITVEDGKSLENELDVVEGMQFDRGYLSPYFINDAEKQIAGLDNPFVLLFDKKISNIRDLLPVLEQVAKASRPLLIIAEDVEGEALATLVVNNIRGVLKTVAVKAPGFGDRRKAMLQDIAILTGAVVISEEVGLSLEKATLDDLGQAKRIEIGKENTTVIDGFGDAAQIEARVAEIRQQIETATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALLRARAALENLHTGNADQDAGVQIVLRAVESPLRQIVANAGGEPSVVVNKVLEGKGNYGYNAGSGEYGDMIGMGVLDPAKVTRSALQHAASIAGLMLTTDCMIAEIPEEKPAVPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, 63 kDa stress protein, Chaperonin-60, Cpn60, GSP63.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: Y1214_WOLPP
Sequence: MAGHSQFSNIKHRKGAQDAKRSQKFTKLIREITVAAKQGLTDPELNPRLRSAIFSARKENLPKDKIETAIKNAAGNVAGESYEEIQYEGCGPSGAALIVHALTNNRNRTASEIRYIFSRKGGNLGETGCVSYLFDHVGLIVYKAEGINFEDLFNYGIELEVLNVEENNKEELYVITCGVKDFGRVRDAFYTKFGEPELARLSWQPKDLIEVSDKELIDKLSILVEELEDNDDVQYVEGNFIFADKL
What are the official names of this protein?
Probable transcriptional regulatory protein WP1214.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYC2_CYPCA
Sequence: MPVSSSLAYKNYDYDYDSIQPYFYFDNDDEDFYHHQQGQTQPPAPSEDIWKKFELLPTPPLSPSRRQSLSTAEQLEMVSEFLGDDVVNQSFICDADYSQSFIKSIIIQDCMWSGFSAAAKLEKVVSEKLASLHAARKELISDSSSNRLNASYLQDLSTSASECIGPSVVFPYPLTESSKSSKVAPSEPMLVLDTPPNSSSSSGSDSEDEEEEEEEEEEEEEEEEEEEEIDVVTVEKRQKRNEAEVSDSRYPSPLVLKRCHVSTHQHNYAAHPSTRHDQPAVKRLRLESSSSNNSSSNRQGKQRKCTSPRTSDSEDNDKRRTHNVLERQRRNELKLSFFALRDEIPEVANNEKAAKVVILKKATECIHSMQLDEQRLLSIKEQLRRKSEQLKHRLQQLRSSH
What is the function of this protein?
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.  Activates the transcription of growth-related genes.
What are the official names of this protein?
Transcriptional regulator Myc-2, c-Myc-2, c-Myc II.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATC_THEP1
Sequence: MIKVTKDLVLHLENLARLELSEDQRESLMKDFQEILDYVELLNEVDVEGVEPMYTPVEDSAKLRKGDPRFFEMRDLIKKNFPEEKDGHIKVPGIHR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: ARGR_PSYIN
Sequence: MKQSTELMTFFKALLEKEHFSSQGEIVEALVNAGFNNINQSKVSRMLSKSGAVRTRNAKQEMLYCLPAELGIPIITSPLKNLVLDIDRNDSMIVIRTSPGAAQLIARLLDSIGKTEGILGNIAGDDTIFTTPTNSKKIQETMNIIKNLFN
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYG_CHLPN
Sequence: MSEHPLTLQSMIATILRFWSEQGCVIHQGYDLEVGAGTFNPATFLRALGPEPYKAAYVEPSRRPQDGRYGVHPNRLQNYHQLQVILKPVPENFLSLYTESLRAIGLDLRDHDIRFIHDDWENPTIGAWGLGWEVWLNGMEITQLTYFQAIGSKPLDTISGEITYGIERIAMYLQKKTSIYDVLWNDTLTYGQITQASEKAWSEYNFDYANTEMWFKHFEDFAEEALRTLKNGLSVPAYDFVIKASHAFNILDARGTISVTERTRYIARIRQLTRLVADSYVEWRASLNYPLLSLSSTSEPKETSESVVPMISSTEDLLLEIGSEELPATFVPIGIQQLESLARQVLTDHNIVYEGLEVLGSPRRLALLVKNVAPEVVQKAFEKKGPMLTSLFSPDGDVSPQGQQFFASQGVDISHYQDLSRHASLAIRTVNGSEYLFLLHPEIRLRTADILMQELPLLIQRMKFPKKMVWDNSGVEYARPIRWLVALYGEHILPITLGTIIASRNSFGHRQLDPRKISISSPQDYVETLRQACVVVSQKERRMIIEQGLRAHSSDTISAIPLPRLIEEATFLSEHPFVSCGQFSEQFCALPKELLIAEMVNHQKYFPTHETSSGAISNFFIVVCDNSPNDTIIEGNEKALTPRLTDGEFLFKQDLQTPLTTFIEKLKSVTYFEALGSLYDKVERLKAHQRVFSTFSSLAASEDLDIAIQYCKADLVSAVVNEFPELQGIMGEYYLKHANLPTASAVAVGEHLRHITMGQKLSTIGTLLSLLDRLDNLLACFILGLKPTSSHDPYALRRQSLEVLTLVSASRLPIDLASLLDRLADHFPSTIEEKVWDKSKTIHEILEFIWGRLKTFMGSLEFRKDEIAAVLIDSATKNPIEILDTAEALQLLKEEHTEKLAVITTTHNRLKKILSSLKLSMTSSPIEVLGDRESNFKQVLDAFPGFPKETSAHAFLEYFLSLADLSNDIQDFLNTVHIANDDGAIRNLRISLLLTAMDKFSLCHWESVAV
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK36_MORIN
Sequence: MKIRASVRKICEKCRLIRRRGRIIVICSNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DXS_PSEU2
Sequence: MPTTFKEIPRERPVTPLLDRADTPHGLRRLGEAELETLADELRLELLYSVGQTGGHFGAGLGVIELTIALHYVFDTPDDRLVWDVGHQAYPHKILTGRRARMSTLRQKEGVAAFPRRSESEYDTFGVGHSSTSISAALGMAIASRLQGSERKSIAVIGDGALTAGMAFEALNHAPEVAADMLVILNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKVLSRLPGAWEIARRTEEYAKGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHVVTKKGKGFAPAEVDPIGYHAITKLEPLNAPAAQKKISAPKYSGVFGQWICDMADADARLVGITPAMKEGSDLVAFSERFPERYFDVAIAEQHAVTLAAGMACEGSKPVVAIYSTFLQRGYDQLIHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENELRKLLSTGYLHTGPAAVRYPRGTGPNAVIEASLDPLEIGKGVVRRQGQGVAILAFGVQLAEALVVAEKLDATVIDMRFVKPLDEALVSEAAANHELLVTLEENAVMGGAGAAVSEFLARANILKSVLHLGLPDVYVEHAKPAQMLTECGLDAQGIEAAINERLALIG
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: SYCP1_MOUSE
Sequence: MEKQKPFTLFVPPRLSSSQVSAVKPQTAGGDSNYFKTANKCTEGDFGVPFTMSSRENIDKDPAFQKLSILPMLEQVANSGSCHYQEGVNDSDFENSEPMSRLYSKLYKEAEKIKKWKVSIESELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATIHWCNLLKETCARSAEKTNKYEYEREETRQVYVDLNSNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYQKEVNNKENQVSELLIQSAEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELSEKKDHLTSELEDIKMSMQRSMSTQKALEEDLQIATKTISQLTEVKEAQMEELNKAKTTHSFVVTELKATTCTLEELLRTEQQRLEKNEDQLKLITVELQKKSNELEEMTKFKNNKEVELEELKNILAEDQKLLDEKKQVEKLAEELQEKEQELTFLLETREKEVHDLQEQVTVTKTSEQHYLKQVEEMKTELEKEKLKNTELTASCDMLLLENKKFVQEASDMALELKKHQEDIINCKKQEERLLKQIENLEEKEMHLRDELESVRKEFIQQGDEVKCKLDKSEENARSIECEVLKKEKQMKILESKCNNLKKQVENKSKNIEELHQENKTLKKKSSAEIKQLNAYEIKVSKLELELESTKQRFEEMTNNYQKEIENKKISEGKLLGEVEKAKATVDEAVKLQKEIDLRCQHKIAEMVALMEKHKHQYDKIVEERDSELGLYKNREQEQSSAKIALETELSNIRNELVSLKKQLEIEKEEKEKLKMAKENTAILKDKKDKKIQASLLESPEATSWKFDSKTTPSQNISRLSSSMDSGKSKDNRDNLRASAKSILPTTVTKEYTVKTPTKKSIYQRENKYIPTGGSNKKRKTAFEFDVNSDSSETADLLSLVSEEDVSNRLYDNNPPDSHLLVKTPKQTPLSLSTPASFMKFGSLKKMREDRWTTIAKIDRKRRLKEAEKLFS
What is the function of this protein?
Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (PubMed:16717126).  Required for normal assembly of the central element of the synaptonemal complexes (PubMed:15937223).  Required for normal centromere pairing during meiosis (PubMed:22761579).  Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:15937223).
What are the official names of this protein?
Synaptonemal complex protein 1, SCP-1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N- terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (PubMed:22761579).
Protein: MUTL_THIDA
Sequence: MSIQVLSDVLISQIAAGEVVERPAAALKEILENSLDAGATAIDVELEQGGVKRIRVSDDGVGIPRDELALALTRHATSKIATLADLEQVASLGFRGEALASIASVARVRLTSRHAGSDHAWTIHVDGGPLQPSSPAARSGGTTIDIEDMFFNTPARRKFLKTEATEYAHCAETVRRLALAWPQVAFTLVHNGRAQLRLKAEAAAARVRHVLGEVFEQHAIAVDAAAGALRLSGWVVRPVAATASRDAQHVFVNGRYVRDKLIVHALREAYRDVLHHQLNPAYCLFVELPPEHVDVNVHPAKTEIRFRDSRGVHQFLYHAVERLLAAPVAPAAPPSGPDARPPTFLQPRQAAMSLQVEEAMAFYAPFAAMAPGEGDEARHVPQASAAGLAGRAGPPRAFASDSSAVPPLGYALGQLHGVYVLAQNAHGLVLVDMHAAHERVVYEKLKTALDRRAVPAQALLIPVALTADPREVAEIAPHLDQLREIGFELSITSPNSVAVRAVPSLLKNADPVELTRAILAEIAEFGVARLLAERRNELLATLACHGAVRAHRTLSVPEMNALLREMEATERAGQCNHGRPTWFQLRLDELDAMFMRGR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: GYS2_MOUSE
Sequence: MLRGRSLSVTSLGGLPVWEAERLPVEDLLLFEVSWEVTNKVGGICTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPTNDAVRKAVDAMNKHGCQVHFGRWLIEGSPYVVLFDISSSAWNLDRWKGDFWEACGVGIPHHDREANDMLIFGSLTAWFLKEVTDHADGKHVIAQFHEWQAGTGLILSRARKLPIATVFTTHATLLGRYLCAANIDFYNQLDKFDIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSNVTVVVFFIMPAKTNNFNVETLKGQAVRKQLWDTVHCLKEKFGKKLYDGLLRGEIPDMNSILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRADRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFVQEHVADPTAYGIYIVDRRFRSPDDSCNQLTQFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHLEPTSPPTTDGFKYPRPSSVPPSPSGSQASSPQCSDAEDEEDEDERYDEEEEAERDRLNIKSPFSLNHFPKGKKKLHGEYKN
What is the function of this protein?
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
What are the official names of this protein?
Glycogen [starch] synthase, liver.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 3 family.
Protein: TRM9B_MOUSE
Sequence: MDPEAVELEKRHVHSVYENTAPYFTDLQSKAWPRVRQFLQDQKPGSLVADIGCGTGKYLKVNSQVHTLGCDYCGPLVEIARNRGCEVMVCDNLNLPFRDQGFDAIISIGVIHHFSTKERRIRAIKEMARVLAPGGQLMIYVWAMEQKNRRFEKQDVLVPWNRALCSRLLSESHQSWGHHCEHPRSRGFQGPGSVCGCAVCFKGRCDSKRSHSMDYGSAVARTCCEAISKEGERENGLYSNFGKSFRSWFFSRSLDESTLRKQIERVRPMKIPEAWANSTVSQQPSRHPSLDLHAPEPFSTKGPNLDEVFVDTSSQRHLGWLRTPGTSDNFSGHKGGGSRRKEGGNFLDITDTGDSVAASNSSDPSARKILRRVSAFDSNDSNSEDSSFLEAQRDATDSKAFMRYYHVFREGELSSLLQESVSELQVLSSGNDHGNWCIIAEKKRSWD
What is the function of this protein?
May modifie wobble uridines in specific arginine and glutamic acid tRNAs.  Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity).
What are the official names of this protein?
Probable tRNA methyltransferase 9B, Probable tRNA methyltransferase 9-like protein.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: PANB_STAA3
Sequence: MKTVSQLIDMKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESTVQVTLADMIHHGRAVRRGAPNTFVVVDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVEQAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDGLKQYDQEVKSGAFPSEEYTYKKKIMNEVNNND
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1552_MYCBO
Sequence: MYAPLVSLMITVPVFGQHEYTHALVADLEREGADYLIVDNRGDYPRIGTERVSTPGENLGWAGGSELGFRLAFAEGYSHAMTLNNDTRVSKGFVAALLDSRLPADAGMVGPMFDVGFPFAVADEKPDAESYVPRARYRKVPAVEGTALVMSRDCWDAVGGMDLSTFGRYGWGLDLDLALRARKSGYGLYTTEMAYINHFGRKTANTHFGGHRYHWGASAAMIRGLRRTHGWPAAMGILREMGMAHHRKWHKSFPLTCPASC
What are the official names of this protein?
Uncharacterized protein Mb1552.
Protein: A16L1_HUMAN
Sequence: MSSGLRAADFPRWKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDREMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAISRAATKRLSQPAGGLLDSITNIFGRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWAQY
What is the function of this protein?
Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:29317426, PubMed:30778222, PubMed:33909989, PubMed:24553140, PubMed:24954904, PubMed:27273576).  Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222).  During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576).  Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576).  Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989).  Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity).  Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662).  Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340).  Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199).  Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
What are the official names of this protein?
Autophagy-related protein 16-1, APG16-like 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ATG16 family.
Protein: RPOE_SALT1
Sequence: MSEQLTDQVLVERVQKGDQKAFNLLVVRYQHKVASLVSRYVPSGDVPDVVQESFIKAYRALDSFRGDSAFYTWLYRIAVNTAKNYLVAQGRRPPSSDVDAIEAENFESGGALKEISNPENLMLSEELRQIVFRTIESLPEDLRMAITLRELDGLSYEEIAAIMDCPVGTVRSRIFRAREAIDNKVQPLIRR
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released.  Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as acid stress, heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment.
What are the official names of this protein?
ECF RNA polymerase sigma-E factor, RNA polymerase sigma-E factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associates with the inner membrane via RseA.
Protein: TBB2_CAEEL
Sequence: MREIVHVQAGQCGNQIGSKFWEVISDEHGIQPDGTFKGETDLQLERIDVYYNEANNGKYVPRAVLVDLEPGTMDSVRSGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVIRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMSSFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICYRTLKLTNPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLSAKGTQAYRALTVAELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMREVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFVGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQEATAEDDVDGYAEGEAGETYESEQ
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (By similarity).  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity).  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity).  Required for the normal dynamic behavior of the non-centrosomal microtubules in the epidermal syncytium (PubMed:31995031).  Involved in the redistribution of microtubule end-binding protein EB1/ebp-2 caused by wounding (PubMed:31995031).  Required to modulate expression in the epidermis of antimicrobial peptides, such as nlp-29, after wounding, or fungal infection (PubMed:31995031).
What are the official names of this protein?
Tubulin beta-2 chain, Beta-2-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.