PharMolix/UniProtQA huggingface dataset:
Protein: MCM6_ANOGA
Sequence: MDVADAHVGQLRVRDEVGVRCQKLFLDFLEEFKEDGEIKYLKTVENLVNPDRSTLEVSFEDVENYNQTLATAIIEEYYRIFPYLCQSVSNFVRDRTSLKKSKECYVSFVDVPTRHKVRELSTSKIGTLIRISGQVVRTHPVHPELVLGTFVCLDCQTEIRDVEQQFKFTNPTICRNPVCANRRRFMLEVDKSLFIDFQKVRIQETQAELPRGCIPRSVEVILRAEMVETVQAGDRYDFTGTLIVIPDVGALQLPGAKAEIGSRHKQGDNAAEGVRGLKALGMRDLNYKMAFLACSVQVTSSRFGGTDMPMSEVTSQIMKDQMTPAEWNKVYEMSRDPRLYQNLINSLFPSIYGNDEVKRGILLMLFGGVAKTTQEKTTLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAVYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLADNGICCIDEFDKMDPHDQVAIHEAMEQQTISIAKAGVRATLNARTSILAAANPIGGRYDRSKSLQQNIQLTAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSHIEHSLDQVYSREDVLRYIMFARQFKPVIQPEAMALLVENYGHLRQRDTGTTGKSTWRITVRQLESMIRLSEAMAKMECSEEVTERHVKEAYRLLNKSIIRVEQPDIHLDEEEGEENENVMDIGEETPEDTPRTNETEENDQDTPAVAKKKLTLSFEEYKNLSNMLVIHMRNEESRMESEELDREGISKTELINWYLSQVEDQLESVEELMERKVLIEKVIDRLIYHDQVIIPLKQAKLGETDQDDAGDQDVLLVVHPNYIVES
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
What are the official names of this protein?
DNA replication licensing factor Mcm6.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Note=Associated with chromatin during cell cycles.
Protein: BRC2_CAEEL
Sequence: MGDSSKKVKDSFDTISEPDSFDEPKGVPISMEPVFSTAAGIRIDVKQESIDKSKKMLNSDLKSKSSSKGGFSSPLVRKNNGSSAFVSPFRREGTSSTTTKRPASGGFEDFEAPPAKKSTSSSSKKSKKHSKKEKKKEFKEIHADVLRVSRIYEKDKFRIILQESSSTPLILATCSYNRGSDIKFGDRIHVDAEVCKKSSSGDVTEIYIDRVLKNKENGAKSGIRRHSIAKKPFCIKPRFIHELSDTKIKKTVVQVNLLDLNLDFYAGCSKCKHSLPEAANQCEFCKDSQGKSELSMYSRVRVMDFSGQMFINVTTKNMKKLLDLLGYEGFDNWFRFKDPQERQNYVFRPVMVEIEKSNDEWECTDVAEVDWKDFGSYLKHKEDKKKRRSKKKHP
What is the function of this protein?
Required for the homologous recombination repair of DNA double strand breaks, thereby playing a role in chromosome integrity (PubMed:15798199, PubMed:16843491).  Acts by targeting rad-51 to sites of DNA damage and stabilizing rad-51-DNA filaments by blocking ATP hydrolysis catalyzed by rad-51 (PubMed:15798199, PubMed:16843491, PubMed:17483448, PubMed:18779660).  Promotes rad-51 mediated displacement-loop (D-loop) formation during strand invasion between the invading single-stranded DNA (ssDNA) and the homologous duplex DNA (PubMed:16843491).  Also functions independently of rad-51 in DNA double-strand break (DSB) repair by promoting DNA single-strand annealing (SSA) when the homologous recombination (HR) and non-homologous end joining (NHEJ) pathways are compromised (PubMed:15798199, PubMed:16843491).  Binds selectively to single-stranded (ssDNA) via its C-terminus (PubMed:15798199).  Involved in telomere maintenance and replicative senescence (PubMed:27761361).
What are the official names of this protein?
DNA repair protein brc-2.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Diffusely localized in the nucleus. Recruited to sites of DNA damage upon induction of DNA double strand breaks by ionizing radiation (IR) or in meiosis.
Protein: CTAA_RHIME
Sequence: MAHAELATEQMLLKEIGRTERNRRQIRGWLAAVLFALFALVLVGGATRLTESGLSITEWKPVHGVIPPLSAEEWEEEFRLYQRIPQYEQINKGMTVDEFKTIFWWEWAHRLLARGIGVIFALPLFFFWVTGRIERRLRLPLLGILALGGFQGFIGWWMVSSGLAERTAVSQYRLATHLTIACLIFAACMWIYRGLCPHSDDAHPTKRSQGMAGAIAIMSLFQIYLGAIVAGLDAGLSYNTWPLMDGAIVPGGLFVQQPAWINLFENPKTVQFVHRLGAYLLFALALWHMIASLRAAPETTHARRSVLLFALVTVQAAIGITTLLLQVPIGWGVLHQGGALVVLGFAIAHWRGFVGTYPRDTAIEMRD
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX3_AEDAE
Sequence: MSTHANHPFHLVDYSPWPLTGAIGAMTTVTGLVQWFHQYDNTLFLLGNIITMLTMYQWWRDISREGTFQGLHTIPVTLGLRWGMILFIISEVFFFISFFWAFFHSSLSPTIELGMVWPPIGIEPFNPFQIPLLNTAILLASGVTVTWAHHSLMENNHTQTIQSLFFTVLLGIYFSILQAYEYIEAPFTIADNVYGSTFFVATGFHGLHVLIGTSFLLICLFRHMNCHFSSSHHFGFEAAAWYWHFVDVVWLFLYISIYWWGN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL34_AEDAL
Sequence: MVQRLTLRRRLSYNTKSNKRRVVRTPGGRLVYLYVKKQRTVPKCGQCKEKLSGIKPSRPSERPRMCRRLKTVTRTFGGVLCHRCLRERIIRAFLIDEQKVVKVLKAQQLGKPVSKPPKIQKTAKAASKSK
What are the official names of this protein?
60S ribosomal protein L34, L31.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL34 family.
Protein: DPO1_HELPJ
Sequence: MEQPVIKEGTLALIDTFAYLFRSYYMSAKNKPLTNDKGFPTGLLTGLVGMVKKFYKDRKNMPFIVFALESQTKTKRAEKLGEYKQNRKDAPKEMLLQIPIALEWLQKMGFTCVEVGGFEADDVIASLATLSPYKTRIYSKDKDFNQLLSDKIALFDGKTEFLAKDCVEKYGILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYENLDLAKNLLSPKMYQALIQDKGSAFLSKELATLERGCIKEFDFLSCAFPSENPLLKIKDELKEYGFISTLRDLENSPFIVENVPILNSTPILDNTPALDNAPKKSRMIVLESAEPLSMFLEKLENPNARVFMRLVLDKDKKILALAFLLQDQGYFLPLEEALFSPFSLEFLQNAFSQMLQHACIIGHDLKPLLSFLKAKYQVPLENIRIQDTQILAFLKNPEKVGFDEVLKEYLKEDLIPHEKIKDFKTKSKAEKSELLSMELNALKRLCEYFEKGGLEEDLLTLARDIETPFVKVLMGMEFQGFKIDAPYFKRLEQEFKNELNVLERQILDLIGVDFNLNSPKQLGEVLYDKLGLPKNKSHSTDEKNLLKILDKHPSIPLILEYRELNKLFNTYTTPLLRLKDKDDKIHTTFIQTGTATGRLSSHSPNLQNIPVRSPKGLLIRKGFIASSKEYCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSKALFGEDLAKEKRSIAKSINFGLVYGMGSKKLSETLSIPLSEAKSYIEAYFKRFPSIKDYLNGMREEILKTSKAFTLLGRYRVFDFTGVNDYVKGNYLREGVNAIFQGSASDLLKLGMLKVSERFKNNPSVRLLLQVHDELIFEIEEKNAPELQQEIQRILNDEVYPLRVPLETSAFIAKRWNELKG
What is the function of this protein?
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
What are the official names of this protein?
DNA polymerase I, POL I.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family.
Protein: RLMG_MAGMM
Sequence: MQHLNIHGHTLTLRRFPHKPGCPLQAWDAADALALTNHALPDGEILILNDHFGALACGLAYPERTLEWVNDSYMAHQALAQNLQLNRIETPLHRTPALAASPTNPVGILIKLPRMLQLLSSQLDWLNLHLPKGTPVVIAARQKDMPSTLPDLTRRLLDDVHPSRAEKKARLIFGQLSGRQSGQAEITAWHCAELDCLLSHYPNVFGRQKLDLGARVLLQNLGTIPDQVVDLGCGNGVLSIAALQRNPNSHVLAVDESWQATRSCQINLERVRTPEHFKVVWGHSLSFIEGMQADLVLCNPPFHQHQTLTDDIAWCMFKDAHRVLKPGGRLRMVGNRHLGYHAKLHKLFGHCRSIAATPKFVVLESVKSS
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_SALDC
Sequence: MERITVTLGERSYPITIAAGLFNEPASFLPLKSGDQVMLVTNETLAPLYLDKVRGVLERAGVNVDSVILPDGEQYKSLTVLDTVFTALLKKPHGRDTTLVALGGGVIGDLTGFAAASYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIGAFYQPASVVVDLDCLKTLPARELASGLAEVIKYGIILDADFFTWLEGNLDALLRLDGPAMAYCIRRCCELKAEVVAADEREAGLRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGIVMAARASERLGQFSSADTQRIIALLERAGLPVNGPCEMSAQDYLPHMLRDKKVLAGELRLVLPLAIGKSEVRGGVSHEVVLSAIADCQQA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDR8_SCHPO
Sequence: MAFSPANSFLINKSICESKEVEPLEANLFGKLHNKLLICKAKKENLEKKLAYQMMYSKLLKSLPKLSSLEENKLTKLKAPIEDMENTKKELEEIRKQSTETELRYLKSLSNTLSFGTLSLSNEINKVGPSASFMLKEVHDSVQVLEQRLEKMGLIEKPSESSESSIYSILASLKHTNDSLQKKELSPHEIAESPSSHSTSPMGRNVDTETLSFLLIDWQRLCAEQNTFLRDITNNMSSSVPQDVLSQLRQFFFRSELLSDKLSNLCSES
What are the official names of this protein?
Uncharacterized protein C16E8.08.
Protein: ACYP_STAAR
Sequence: MRHIHLQVFGRVQGVGFRYFTQRIAMNYNIVGTVQNVDDYVEIYAQGDDADIERFIQGVIEGASPASNVTSHQLEELELNQKLSDFRSI
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: NUBP1_DROVI
Sequence: MQAPPPEHCPGVESEQAGLVSACAGCPNQSICSDPSKKLEDPGKALVAAAMKDVKHKLLILSGKGGVGKSTVTTLLTRYLARSYPDNNFGVLDIDICGPSQPRLLGALGENVHQSGSGWSPVGIDDNVCLMSIGFLLGSVDDAVIWRGPKKNGMIRQFLSEVDWGNLDLLLLDTPPGTSDEHLSVVSYLRDDNAPESLHAIIVTTPQEVALLDVRKEINFCKKQRIPILGVIENMSSFRCGHCGNSSEIFPAKTGGAAAMCIEMDVPLLGSLPLDPLVTRSCDAGEDITAMRNETTEALATICSKIMSSL
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery.  Required for maturation of extramitochondrial Fe-S proteins.  The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NUBP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PERM_HAEIN
Sequence: MLEMLKSWYSRRLSDPQAMGLLAILLFGFISIYFFGDLIAPLLIALVLSYLLEIPINFLNQYLKCPRMLATILIFGSFIGLAAVFFLVLVPMLWNQTISLLSDLPAMFNKSNEWLLNLPKNYPELIDYSMVDSIFNSVREKILGFGESAVKLSLASIMNLVSLGIYAFLVPLMMFFMLKDKSELLQGVSRFLPKNRNLAFXRWKEMQQQISNYIHGKLLEILIVTLITYIIFLIFGLNYPLLLAFAVGLSVLVPYIGAVIVTIPVALVALFQFGISPTFWYIIIAFAVSQLLDGNLLVPYLFSEAVNLHPLIIIISVLIFGGLWGFWGVFFAIPLATLVKAVINALPQD
What are the official names of this protein?
Putative permease PerM homolog.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFTS_HYDS0
Sequence: MAVSSENVKLLREMTGAGMLDCKKALEEANGDIDKAKEILRIKGLAKADKKASRETKEGLIVAKSTPSKGAMVELACETDFVARNGSFKELANKILDYVLENVGDTKGESRDSSILQGKIDGITIEELLKEAIAKIGENIQLKRYCVVEGPNFSYIHGGGRIGVLLSYEGDNLDVVKDVALQIAAMRPEFLSPETVPQDVIEREKAIYMEQAKKEGKPENMLEKIAEGKLKKFYEEKTLLHQKFIKDEKKTIQDYTKANNVTIKGFCRFEIGT
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_VESOH
Sequence: MQLKDFDFDLPASLIAQHPIKNRTDSRLLIKRSSIIDIQFNQIGDFFQSGDLLIMNNTKVIPARLFGTKETGGKVEIMIERILDENQVLAMIKASRAPKIGSCIFLENDVNIIVYQKDNGFYTLIFETDSLFDLLNNIGHTPLPPYIKRTNNVQDLSRYQTVYAQKDGAVAAPTAGLHFDDSLLAQLKIQGIDHLFVTLHIGSGTFTPIRTDNIKNHVMHSEIFEISQVTVDRINLTKANGGRIIAVGTTTVRVLESSLKNGKLIAQNGETDIFIYPSYQFRIVDSLITNFHLPKSSLLMLVSAFIGRDKMLELYKHAIEQKYKFLSYGDAMFLEKNNDL
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEP4_TRIRU
Sequence: MHGLMLAGLLALPLSVLGHPTESHSSGISRRAIDITSYRLPQISKYTKSDAVPKQDGESFTTSSTGNDNSSSGDYVTTATNWLKKTLPKATYRLVKDHYIGDSGIGHVHFRQTAHGIDIDNTDFNVNIGRDGKVFSFGNSFYDGEIPKANPMVKRDFSDPVNALHGAIQILNLPVTAKPENVKAKPVEGKENFKFEGTSGALSDPKAQLVYLQKDGGLVLSWKVETDVGDNWLLTYVDANKNDKVHSVVDYVSAAEYQVYPWGINDPTEGNRTTLHLPWLKTLSTDWHIDGKGWYSTTRGNNAIAQENPTGGPEYENNYRPKSPLFIFKYPYSKAMTPPSSYRDASITQLFYTTNVYHDVLYILGFNEKAGNFQINNWNKGGVGGDYAILNSQDGSGVNNANFATPPDGQPGRMRMYTWNASIPERDGCFEAGIVIHEYTHGVSNRLTGGPENSRCLAALESGGMGEGWSDFFATAIRLKPGDTRVTDYTMGEWASNRPNGIRKYRYSTSLTTNPHMYVDADGLTSVHAIGNIWASMLYELLWNLIDKHGKGDVTKIRPVLKNGVPTDGRHLAMKIVLDGMALQPCLPNFVQARDAILDADKNLTQGSNKCEIWKAFAKRGLGVGAVFNLSKRTGSNELPAGC
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Extracellular metalloproteinase 4, Fungalysin MEP4.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KATG_FRATT
Sequence: MLKKIVTALGMSGMLLASSNAIAEDTTTKNDNLSPQSVDLSPLRNLNKLDSPMDKDYNYHQAFKKLDTEQLKKDMQDLLTQSQDWWPADFGNYGPFFIRLSWHDAGTYRIYDGRGGANRGQQRFSPLNSWPDNVNLDKARQLLWPIKQKYGDAVSWSDLIVLAGTVSLESMGMKPIGFAFGREDDWQGDDTNWGLSPEEIMSSNVRDGKLAPAYAATQMGLIYVNPEGPDGKPDIKGAASEIRQAFRAMGMTDKETVALIAGGHTFGKTHGAVPEDKVKQAIGPAPDKAPIEQQGLGWHNSYGTGNGDDTMGSGLEGSWTSTPTFWNHDFLHNLYNLDWKKTLSPAGAHQWTPTNAKPENMVPDAHKPGVKHKPIMFTTDLALKEDDGFNKYTQEFYNNPEEFKEEFAKAWFKLTHRDMGPKSRYIGPWIPEQNFIWQDPVPAADYKQVSTQDIAQLEQDIINSGLTNQQLIKTAWDSASTYRKTDYRGGSNGARIALAPEKDWQMNEPAKLEVVLTKLKEIQTNFNNSKTDGTKVSLADLIVLGGNVGVEQAAKQAGYNIQMPFVPGRTDATQAQTDIESFNYLKTKSDGFINYTDGSVSADKLPQTLVEKASMLDLNIPEMTVLVGGMRALDVNYDNSQEGVLTTTPGQLNNSFFVNLLDMSTQWKKSDKKDGEYIGIDRKTGKQKWTASPVDLIFGSNSELKAVAQVYAENGNEQKFVNDFAKAWHKVMMLGRFDVQQ
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
What are the subcellular locations of this protein?
Secreted. Periplasm. Note=Released by the bacterium intracellularly in host macrophages.
Protein: G2OX2_PEA
Sequence: MVVPSPTSMIRTKKTKAVGIPTIDLSLERSQLSELVVKACEEYGFFKVVNHSVPKEVISRLDEEGIEFFSKNSSEKRQAGTSTPFGYGCKNIGPNGDKGELEYLLLHSNPISISERSKTIAKDHPIKFSCIVNDYIKAVKDLTCEILELAAEGLWVPDKSSLSKIIKDEHSDSLLRINHYPPVKKLGNDNWDPSKIQNSNNNNIGFGEHSDPQILTILRSNNVGGLQISTHHGLWIPVPPDPSEFYVMVGDALQVLTNGRFVSVRHRVLTNTTKPRMSMMYFAAPPLNWLISPLSKMVTAHSPCLYRPFTWAQYKQAAYALRLGDTRLDQFKVQKQEDSNDSHSL
What is the function of this protein?
Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level.  Catabolism of gibberellins (GAs) plays a central role in plant development.  Converts GA9/GA20 to GA51/GA29 and GA4/GA1 to GA34/GA8.
What are the official names of this protein?
Gibberellin 2-beta-dioxygenase 2, GA 2-oxidase 2, Gibberellin 2-beta-hydroxylase 2, Gibberellin 2-oxidase 2.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family. GA2OX subfamily.
Protein: MNMC_SHESM
Sequence: MTAKPQKSCQFKRDYPQLINLYPPCALTTAQSLDNLTRLRLSRLTTQSTQPIQGLCVMGQWGLGDGLELLSLLQHWQTQTQTQGNTRLLVKVFEPNPINDYELKLLWDQSQSLISKSHLQPIANAILKAKPARIIGCQRLIFDDGRITVDLHFGDLHTALSQLPHSADHPIQQWLVLPHLAAQLNGKQVWQMARLSTDDAQLIGVNLAETLQQLAHKSGFSTLNVSQDALNGDASDALQSHIITDEILLHERKLLRQQADTAQAFTPKPTALATKDHPIAIVGGGLASANLMLSLAERGQSSTLFCKDNELGQGASGNRQGAIYPLLTPENDELSRFFQQAFLFSRRRIEALSHASMMETEAAPTITAISHDFCGVLQTGHDERSQQRLDKIIQSQDWPAEIAYAVDANEANEIAQIGIDKAGFFYPLGGWVCPFEYAKAAVDKASQLANVQCHFNTEITEIECDAKAWYLHSQGQRFGPFRQLVLANGAQLTQFSASERLQISPFRGQVSHVPAQFKLSQLATVLCANGYLTPSHQGLHCLGASYVKAAEHLDFCPQEQWENLGKMQESYPNQAWVDDIDISDNSARVGVRMVTRDHFPMMGCAPDVAEILARYEQHQLNQQQAEQSKHYWQTTPAPILDGLYILGGLGSRGLSSGPLAAECLAAQLTGEPLPLDWPTLNKLNPNRMWLRKLLKGKAL
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH601_NOCSJ
Sequence: MPKILEFDEHARRALERGVDALANAVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAREVELDDPFENLGAQLTKEVATKTNDIAGDGTTTATVLAQAMVHEGLRAVTAGANPMGLKRGMDAAAEAVGDALKEAAREVESREDMASVATISSRDSVIGDLLAEAFDKVGKDGVITVEESNTMGTELEFTEGMQFDKGYISQYFVTDPERMEAVLEDPYILLHQGKISAVAELLPLLEKVIQSGKPLFILAEDVEGEALSTLVVNKIRGTFNAVAVKSPAFGDRRKAMMQDIATLTGGQVVAPEVGLKLDQVGLEVLGQARRVVVTKDDTTIVDGAGDPKDVEGRVNQIKAEVENTDSDWDREKLQERLAKLAGGVCVIKVGAATEVELKEKKHRIEDAVSATRAAIEEGIVAGGGSALVHAVSVLSDDLGLTGDEALGVRVVRKAADEPLRWIAENGGVNGYVVTTKVRELGLGNGFNAATEEYGDLVAQGVLDPVKVTRSALVNATSIAGMLLTTETLVVDKPEEEEPAAAGHGHGHGHGH
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_COXBR
Sequence: MPNQNLIALGFDFGMKRIGVAVGQTVTHSANAIAILKAQDGVPDWEKIKMLIETWHANVLVVGIPYNMDGSEQTLTFAARKFARKLQMRFGLPVSMVDERLTTIEAKRQWYEQGLTKRPQHLDNYAAKLILEQWLQEQKNE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXX_MYCBO
Sequence: MNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAATGANTLNCVADADIDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVLALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EXO70_ASPFU
Sequence: MVAPRHNAYAEESAEVEVLYANLEKLKLLTKKIQGSLVRLETGGNVVKHAIGPIYSNTQSLQITNSNIDKVNEAIERLRQPLDAKNREEGIIRAGPQSVELSQYLAAMKRVDKALVDLSSTNLKSNQKAISEFNNLLSTGNAKLQDMLRGILNQYASPIEPLHYLTKDLPFPSIPQETISELTSICAAIDSAASHGPQRGDGGNPALKIYADVRGAYLTSSLQNLAIASLNTVKRRAADGPYKQGTNGIGIYSNALENFISTEYEIIAQIFTGDQRGLALQTTFRSALAEYSKTLRELNEYIKANLMTDCFLAFEIIEIVTAMSYRVDSRTGELKSLFIEALRPVRETAKSSLSELLEETKRKAASIPVLPPDGGSVPLVNEVMSSLTTLTGYSGPLASILTSLGDGNWRSTANASGTAPLDVSPDSSALLSHFILDMIEALMSSLEARGRALHRSKAVQGVFLSNVFCIVDRAIRQSPELARHLGTPDSIARIDTFRKRATSTYLDAWKETSQYLLDVQYTSRAGARPASGGIVDSSAIVKSLSSKDKDAIKDKFKAFNASFDELVNRHKALYMEREVRGVLAREVQAVLEPLYARFWDRYHEIDKGRGKYVKYDKGSLSAQLAALA
What is the function of this protein?
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis.  Also plays a role in the assembly of the exocyst (By similarity).
What are the official names of this protein?
Exocyst complex protein exo70.
What is the protein family that this protein belongs to?
Belongs to the EXO70 family.
What are the subcellular locations of this protein?
Bud. Bud neck.
Protein: WTSA_PANSE
Sequence: MNIENNEHSFRPHPELGEHISFTKEQPIDIHDSLASLIETVAPLEIDLVLEGETGTGKDTLARKIHRLSGCSGRLIAVNCAAIPETLAESELFGVNNGAYTGAVQARAGYIEEANNGILFLDEIDSMPLSLQAKLLRVLENRGIERLGGTRFIPVNMRVIVATQKPLLTLVEQGTFRRDLYFRLNTLSIQLQPLRSQVEIIIPLFRHFIAKAATTMQCTPPEITQELCEYLLSYSWPGNIRELKTAAKRFTLGLPPLNVPRNAERQGPQLKEILRRIEKSLIHDCLVRHGHSIDEAAMELGMPLRTLYHRIKLLNVTTQRIIV
What is the function of this protein?
Positive activator of wtsB involved in plant pathogenicity.  Probably interacts with sigma-54.
What are the official names of this protein?
Pathogenicity locus probable regulatory protein WtsA.
Protein: LYEL_HALSA
Sequence: MFRYLFVLSRPRFWLYLAGPVLVGVSYGATTVGELFSAPAVVLFSYFLLPANIYLYGINDVFDRDVDETNPKKDGRESRYRGGAAVAVIVAVCGVFLGFVAAPLPAEAWPYLAAWFVLATEYSAPPLRFKTTPVLDSLSNGLYVLPAAAAYAGVSGTHPPLLAVAGGWLWAMGMHTFSAIPDIEPDRAAGIQTTATALGADRALAYCAGIWLLSAAVFALVDVRFGLLLLAYPVLVFGIRRLQVAVGRAYWWYPAVNTLVGMVFTLGGLWGVVHG
What is the function of this protein?
Involved in the biosynthesis of the acyclic C50 carotenoid bacterioruberin (BR) (PubMed:21840984).  Acts as a bifunctional elongase/hydratase that catalyzes the elongation of lycopene by attaching a C(5) isoprene unit at C-2, as well as the hydroxylation of the previous end of the molecule (PubMed:21840984).  The enzyme acts at both ends of the substrate, and catalyzes the conversion of lycopene to the C(45) intermediate dihydroisopentenyldehydrorhodopin (DH-IDR) and the conversion of isopentenyldehydrorhodopin (IDR) to the C(50) carotenoid dihydrobisanhydrobacterioruberin (DH-BABR) (By similarity).  Can also catalyze the conversion of lycopene to tetrahydrobisanhydrobacterioruberin (TH-BABR) (PubMed:21840984).
What are the official names of this protein?
Lycopene elongase/hydratase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.