PharMolix/UniProtQA huggingface dataset:
Protein: TTCA_COXB1
Sequence: MSEKRVEKKLIHYVKKALNDYHMINTGDRVMVCLSGGKDSYTLLSLLNSIRIEGNYKFDIFAFVLDQSQPGWDDSALRGWLDDKKIPYEILTRDTYSIVKEKIPAGKMYCSLCSRLRRGIIYRYAEEQGFSKIALGHHRDDLIQTLLMSVFYNGQIRSMPPKLLSDNKRHVLIRPLAYCQERDIIKYAMEQQFPLIPCNLCGSQKNLMRQRVKRLISDLAKENPKVPSNMLRALSNIKPSQLMDHELWNFRELNVD
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH601_RHOPS
Sequence: MSAKEVKFGVDARDRMMRGVDILANAVKVTLGPKGRNVVLDKSFGAPRITKDGVTVAKEIELDDKFENMGAQMVREVASKSADAAGDGTTTATVLAQAIVREGGKAVAAGMNPMDLKRGIDLAVEAVVADLVKNSKKVTSNEEIAQVGTISANGDVEIGKFLSDAMKKVGNEGVITVEEAKSLETELDVVEGMQFDRGYISPYFVTNADKMRVEFDDAYILINEKKLSNLNELLPLLEAVVQTGKPLVIVAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLQDIAILTGGQAISEDLGIKMENVTLQMLGKAKKVMIDKENTTIVNGAGKKADIEARVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEIEVKERKDRVDDAMHATRAAVEEGIVPGGGVALLRASEQLKRIKTQNDDQKTGVEIVRKALSAPARQIAINAGEDGSVIVGKVLEKDQYNYGFDSQTGEYGDLVKKGIIDPTKVVRTAIQNAASVAALLITTEAMVAELPKKGGAAGGMPPGGGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHMD_ECOBW
Sequence: MENIMTLPKIKQVRAWFTGGATAEKGAGGGDYHDQGANHWIDDHIATPMSKYRDYEQSRQSFGINVLGTLVVEVEAENGQTGFAVSTAGEMGCFIVEKHLNRFIEGKCVSDIKLIHDQMLSATLYYSGSGGLVMNTISCVDLALWDLFGKVVGLPVYKLLGGAVRDEIQFYATGARPDLAKEMGFIGGKMPTHWGPHDGDAGIRKDAAMVADMREKCGEDFWLMLDCWMSQDVNYATKLAHACAPYNLKWIEECLPPQQYESYRELKRNAPVGMMVTSGEHHGTLQSFRTLSETGIDIMQPDVGWCGGLTTLVEIAAIAKSRGQLVVPHGSSVYSHHAVITFTNTPFSEFLMTSPDCSTMRPQFDPILLNEPVPVNGRIHKSVLDKPGFGVELNRDCNLKRPYSH
What is the function of this protein?
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
What are the official names of this protein?
L-rhamnonate dehydratase, RhamD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
Protein: MPTA_METKA
Sequence: MRSCFPDVQSADPQIPAHLTRVGISGIKKLVKIPRRGKRSIVLVSTFNLFVDLPAHQKGIHMSRSHEVLQEVLEELEMSVEGSDTVIEDLCSRISRRLLERHDYATRSEVYMTGELILSRRTPVTKLPTQEPYKIIGRAVSKRTDNGIETRKMVGAEVVGLTACPCALEMMREHGKERVKHRLMEELDLEEEEAEDLAKKIVREDVHPMTHNQRGVGTILIEVSDVHRVSINDIIEIIEESMSAPTYELLKRPDELKVTCSACENPKFVEDCVREMIRRIVERFDYLPDDAVVIVRQVNKESIHKHDAFAERVTTMGELRKELGS
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: C75A3_PETHY
Sequence: MVLLSELAAATLIFLTTHIFISTLLSITNGRRLPPGPRGWPVIGALPLLGAMPHVSLAKMAKKYGAIMYLKVGTCGMVVASTPDAAKAFLKTLDLNFSNRPPNAGATHLAYGAQDMVFAHYGPRWKLLRKLSNLHMLGGKALENWANVRANELGHMLKSMFDMSREGERVVVAEMLTFAMANMIGQVILSKRVFVNKGVEVNEFKDMVVELMTTAGYFNIGDFIPCLAWMDLQGIEKGMKRLHKKFDALLTKMFDEHKATSYERKGKPDFLDCVMENRDNSEGERLSTTNIKALLLNLFTAGTDTSSSAIEWALAEMMKNPAILKKAQGEMDQVIGNNRRLLESDIPNLPYLRAICKETFRKHPSTPLNLPRISNEPCIVDGYYIPKNTRLSVNIWAIGRDPEVWENPLEFYPERFLSGRNSKIDPRGNDFELIPFGAGRRICAGTRMGIVMVEYILGTLVHSFDWKLPSEVIELNMEEAFGLALQKAVPLEAMVTPRLPIDVYAPLA
What is the function of this protein?
Catalyzes the 3'5'-hydroxylation of naringenin and eriodictyol to form 5,7,3,'4',5'-pentahydroxyflavanone and 3',5'-hydroxylation of dihydrokaempferol and dihydroquercetin to form dihydromyricetin.
What are the official names of this protein?
Flavonoid 3',5'-hydroxylase 2, F3'5'H, CYPLXXVA3, Cytochrome P450 75A3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Microsome. Endoplasmic reticulum.
Protein: DNAA_AZOVD
Sequence: MSVELWQQCVELLRDELPAQQFNTWIRPLQVEADGDELRVYAPNRFVLDWVNEKYLGRLLELLGERSEDVTPSVSLLIGSKRSSAPRAVQPASPPPAVVQAAPVAIEEASAARTVDAQPVAPATVRTERSVQVEGGLKHTSYLNRAFTFENFVEGKSNQLARAAAWQVADNPKHGYNPLFLYGGVGLGKTHLMHAVGNHLLKKNPNAKVVYLHSERFVADMVKALQLNAINEFKRFYRSVDALLIDDIQFFAKKERSQEEFFHTFNALLEGGQQVILTSDRYPKEIEGLEERLKSRFGWGLTVAVEPPELETRVAILMKKAEQTKVELPHDAAFFIAQRIRSNVRELEGALKRVIAHSHFTNHPITIELIRESLKDLLALQDKLVSIDNIQRTVAEYYKIKIADLLSKRRSRSVARPRQVAMALSKELTNHSLPEIGDSFGGRDHTTVLHACRKIAELRETDADIREDYKNLLRTLTT
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNA_BACSU
Sequence: MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDAIVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSWALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTICNAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLITDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLSTFDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGIMTGNYEEEIEQLFKGEKVH
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: SHB_MOUSE
Sequence: MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERREQPPQAVPQACSASSASCGSAAACFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGGGGGDPGGGQRAFTAAAGAAGCCCAAAGAGAAASSSSSSGSPHLYRSSSERRPTTPAEVRYISPKHRLIKVESASAAGDPPGGVCSGGRTWSPTTCGGKKLLNKCSAEETGAGQKDKVTIADDYSDPFDAKSDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSLRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPTIPLEKQIWYHGAISRSDAENLLRLCKECSYLVRNSQTSKHDYSLSLKSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL
What is the function of this protein?
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components.  May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling.  May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades.  May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity).
What are the official names of this protein?
SH2 domain-containing adapter protein B.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Protein: GATC_HELMI
Sequence: MALTKAEVEYVAMLARLELSEADLERYTTQLNAILDYAQRLQGLDTKDVPPTAHVFPLHNVMRDDRIDPSMERERIVANAPEEEDGFFRVPRIV
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: SODF_CAMJE
Sequence: MFELRKLPYDTNAFGDFLSAETFSYHHGKHHNTYVTNLNNLIKDTEFAGKDLVSIIKTSNGGVFNNAAQVYNHDFYFDCIKPSTGCGCGGSCQSIDANLQAALEKEFGSLENFKAEFIKGATGVFGSGWFWLVYNTKNQKLEFVGTSNAATPITEDKVPLLVVDVWEHAYYVDHRNARPAYLEKFYAHINWEFVAKAYEWALKEGMGSVSFYANELHPVK
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Fe].
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: RLMKL_FRAP2
Sequence: MQNFTFFASCAKGIELLLKDELDALGISSSEKLAGVEFEGSFEDAYKVCIYSHLASQVMLKIATQKVTDQQALYDFISSINWLDYFDVNTAFKIIISGKHYDFNNTMFVSQKTKDAIVDQFRRETNERPNIDTDNPDNIIKLHLHKQYVNVFLCLNIESLHKRSYRQFQGQAPLKESLAAAILIKAGWLDELKKEQPILIDPMCGSGTILIEAALMAKNIAPVLLNKEFKLFNSKLHDEDLWNNLLEIAKKAQKPTNAIIQGYDIDNNVLDKADRNIYQAGVEDVVNIKRQDIRDLENELESEGLIVTNPPYGERLYGDQLDELLDIFNGFGDRLSQDFYGWKVAILTSFDESIKEMQLRTTKKNKFYNGAIETVLYQFDINEHARFKHESQLEKNIRLAEASALKSDEHIDFSNKLKKNLKNLKPWLKQSGVECYRLYDADIPTFAVAVDIYGEHVFLQEYRADATIDQNIAKQRFYQAIYQIHKTLDIQYENIHTRVRQRQKGKEQYQKNNDRNNFHVINEFNAKFYVNFDDYLDTGIFLDHRKIRQLVAKASKNKTLLNLFSYTCTASVHAALKGAKTTSVDMSNTYLEWGKNNFELNNLDIKKHNFIQADCISWLKSNSEKFDVIFLDPPTFSNSKRMDDILDIQRDHELLINLAMDSLKKDGVLYFSNNYRRFKMSQEIIAKFNCENIDKVCLSRDFLSNKNIHNCWEIKYKK
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHN_PROM5
Sequence: MPLLLSGKKFHNDLKKNKCLAMFAPLEGGYETRLLRRMRAKGFKTYITSARGLGDPEVFLLNLHGIRPPHLGHQSIGRNGALGEVQQVIPQASELFNENDKDKLLWLLEGQVLSQSELENLIKLPTADNKLKIVVEMGGSRKLEWKSLNDYVLNEF
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit N, NAD(P)H dehydrogenase I subunit N, NDH-1 subunit N, NDH-N.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhN subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL5_RHOPA
Sequence: MAETAYVPRLRTEYDRHIRTQLTEKFGYANVMQVPKLDKVVLNMGVGEAVNDRKKAEQAAADLSLIAGQKAVITYSRVAISTFKLRENQPIGCKVTLRQARMYEFIDRLITVALPRVRDFRGLNPKSFDGRGNYSLGIKEHIIFPEIDFDKTGESWGMDITVCTTARTDDEARALLTAFNFPFRQ
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5, RRP-L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ISPF_PROM2
Sequence: MTSKSPKFRIGNGYDIHRLEIGRKLIIGGVKLNHPDNLGLDGHSDADVLSHSIMDALLGALSLGDIGKYFPPSDEKWKDVDSLILLSKVIDLVRKQGWEINNIDSVIVAERPKIKPYVEIMKRNLSKTLKIDDSFIGIKATTNEKLGPEGREEGISCHSVVLLEKK
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: HAUS1_MOUSE
Sequence: MAAPEEKALQVAEWLKKVFGDHPIPQYEMNSRTTEILYHLSERNRVRDRDISLVIEDLKQKASEYESEAKRLEDFLMESVNFSPANLSKSGSRFLNALVDSAIALEIKDTSLASFIPAVNDLTSDLFRTKSKSEEMKLELGKLEKNLTATLVLEKCLREDLKKAELQLSAEKAKVDSRLQNMDFLKAKAAEFRFGIKAAEEQLSARGMDASLSHRSLAALSEKLSELKEQTIPLKKKLESYLDLMPSPSLAQLKIEEAKRELDAIEAELTKKVDMMGL
What is the function of this protein?
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
What are the official names of this protein?
HAUS augmin-like complex subunit 1, Coiled-coil domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the HAUS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes with the spindle poles in mitotic cells. In interphase, localized at the centrosome and diffusely in the cytoplasm. Localizes to mitotic spindle microtubules (By similarity).
Protein: RPF2_SCHPO
Sequence: MLRQVKPKNARTKRALEKREPKLVEGAKTAIFLRGNATSQISLDVLGDIHALKKPFSVNFQKKNNILPFEDASSLEFFSEKNDAALAVMATHNKKRPHNLTWVRFFNYRVLDMIELGIVNYKSIQSFSATPIVPGTKPMILFQGPVFDAHPTYRHIKSLFLDFFRGEPIQKLDSAGLSYVIVVSAAEAQEDETKPLPLVHFRVYGTKLLKTKTNLPRVELEEMGPRIDFNIRRVQPAESDVLEEALKKPKTQEPKPKKNVDVDIIGNKVGRIHVDQQDLGNLQTRKMKGLKRSVEEREDSENEEVEIEEDVISDASE
What are the official names of this protein?
Ribosome production factor 2 homolog, Brix domain-containing protein 1 homolog, Ribosome biogenesis protein RPF2 homolog.
What is the protein family that this protein belongs to?
Belongs to the RPF2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: IOC2_YEAST
Sequence: MRTKRTRGTRNVGASMPAGAANADSEDWKEYVSEDIIAQLNKHQLPYSEILDEKIADLANHWHFQYVMAWLSNVCESYTTTTFNTDQYGGSSTKCLWKNIKFDEGVFVTDVFSKIDGKDSNYYNDEVDVDEGSQNLYDRIRLQLLHQLAGNKSGQLKDWNVIVNHHLQNSSAYSDLVTDLPFLELEIARQFDIIYSIIKLIEMKNMIFKNYLANNLHLFTFSEVILDDDNSGGEEMKSLFALPNVGVLVKKTIHRVKEGSSSQVSQTLNIPIKLQNCTIKESDPDIPDSVELIHLEYSHDIDAYLQSITIDYDVITTNWGSMLEYWSENKSSKAIDEFITNLIPVYAEHRLYSAKLLANREKERAIAELMTRRKRSSRLVAKEEENKKKDLESEWFEKLDEREQFIRHRNKLVSKEIKKIKDLLWNQLWQLYDQDYRDEKLTRRNELKDRSGSGTPFFETSLGREEDNPLNEIDIGVLDHGPNFQSSIIPVEPPIPGTVGPLQTGDVPELPSDFCITKEELDELANYGIFTPQQEPDNQDSVFQCPGEPELAPMIITEDTETDLFNNRPLICCDHCYRWQHWECQPPKIIELISSTTKSPQHTLSQRDFGVIIMGNSHGNRRSSRRPQSTLEPSTKSSRPTDKRKPLSECSTFICAWCIRDLELELRNIFVPELKIIRAKQRKQQEDRERRKKMKEEKKRLEELAKKRELTESVSPPVFNNAFANMSSSTTPSIAAYEKTNPAINPAPNVNAAHPIITYSQQTGSKTVPQAPQAPQTSQASIQPQQQQQQQQQQQPLHPKEQNFHFQFPPTN
What is the function of this protein?
Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA.  The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.
What are the official names of this protein?
ISWI one complex protein 2.
Protein: SCPB_LISMO
Sequence: MNREEQLGVLESLLFAAGDAGLSTEQLTEVMEITHIEALNLLELLSERYNESADRGLILLELAGTFQLATKKAHAEFLRKLVEVPSNTVLSQASLETLAIIAYRQPVTRMEVDEVRGVQTDGPIRTLVAKGLVTDKGRVDGAGRAKLYVTTSEFLDAFGLNSLEDLPKLADPATDEPDQNEMDLFFDRFNQSKEQEEE
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: NDD_BPR32
Sequence: MKYMTVTDLNNAGATVIGTIKGGEWFLGTPHKDILSKPGFYFLVSKLDGRPFSNPCVSARFYVGNQRSKQGFSAVLSHIRQRRSQLARTIANNNVPYTVFYLPASKMKPLTTGFGKGQLALAFTRNHHSEYQTLEEMNRMLADNFKFVLQAY
What is the function of this protein?
Disorganizes the host nucleoid and inhibits replication, but without host DNA cleavage or degradation.  Only the architecture of the nucleoid is affected.  May act on the host chromosomal sequences that determine the structure of the nucleoid.  Binds to dsDNA but not to ssDNA.
What are the official names of this protein?
Nucleoid disruption protein, Nuclear disruption protein.
Protein: AMPA_STRMK
Sequence: MALEFTLNHVAPAAAVDCLVVGAYADHTLTPAAQALDAASGGRLTSLAQRGDLSGKTGATTLLHDLPGVSAPRVLVVGLGDAARFGVPQYLKAVGDAVRALKAGATRSALFTLSEVAIKDRDAAWAIRQAVIAADHAAYRYTATLGKKKTDDAGLAQLAIAGDDALALAQGQAIAAGVEFARELGNLPPNYCTPAYLAEVGVKFAGEHDGAEAEILDEHQMEALGMGSLLAVARGSANRPRLVVLKWTGGGDAKPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGANVIGTFVAAVKAKLPLNLVVVVPAVENAIDGNAYRPSDVITSMSGKTIEVGNTDAEGRLILCDALTYAQRFEPAALVDVATLTGACMVALGHQTAGLMSKHDDLANELLAAGEHVFDRAWRLPLWDEYQPMLDSTFADVYNIGGRWAGAITAGCFLSRFTEGQRWAHLDIAGVASDEGKRGMATGRPVGLLSQWLLDQAARA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPTH_AERPE
Sequence: MQSRELREQLLGCVKSRKSLHVTGPPGSGKSTFVSRLAEALRVKGCRLGGFMAPEVRRGGRRVAFKIVDIASGEEGYLAVADESLAAPGGRRARHGRYLVLVDEAWRVMSHAIRNAFEHADIIIVDEIGPMELAVPGFREALTEILDSGKPLVTVFHRRLRTLDPGLYKLLERGCIVWLDERNRGPLIRLVSEIASALSNEACGNS
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: LEPA_ACIB5
Sequence: MAQAKKSVDIKNIRNFSIIAHIDHGKSTLADRFIQMCGGLQDREMQAQVLDSMELERERGITIKAASVTLYYTHPNGQEYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAIEQGLEVLPILNKIDLPQAEPERVIHEIEEIIGIEATNAPTCSAKTGLGVEGVLETLVDVIPAPTGDREAPLQALIIDSWFDNYLGVVSLVRIKDGRIRKGDKMLVKSTGQTHIVTSVGVFNPKHTETGVLEAGEVGFVIAGIKDIFGAPVGDTITLSTTPEVASLPGFKKVKPQVYAGLFPIDASDFEPFREALQKLQINDSALFFEPESSDALGFGFRCGFLGMLHMEIVQERLEREYDLDLISSAPTVVYEAVTKKGDTIYIDSPSKMPDGSVVEDLREPIAECHILVPQEYLGNVMTLCIERRGVQKDMKFLGNQVSITFEIPMAEVVMDFFDKLKSCSRGFASLDYNFIRFESSSLVKVDVLINGEKVDALAMICHRNDARHRGIALVEKMKDLIPRQMFDVAIQAAIGAQIIARSTVKAMRKNVLAKCYGGDVSRKKKLLAKQKEGKKRMKQVGSVEIPQEAFLAVLKVER
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CTVD_ASPTN
Sequence: MALSAYFLLCLSVLGLDAIYGFGFRNGFLELMANSYRERKLSGTAEPLQGNITGTGLDELLGNLIVFYWPVLDGNHPGLSLQAFHFLGAIVAVWVAIQVQSWRSPNRNSLLRSPTLFAMLSQVVAIAVIVPLWCAISIWSSSSPRPITRAVSASAAHSIRLIPISMVLGFGIPTIGMLLPESTHQNLFSKQIAIAVWQIWPIYVALWHWGLRVLFRSRLKEGISVRTACRTACSFAFVCAIIPHAVSWGLSLTLIPTNLLADVLPWQFAGGGTVQVQSMAQGGLWFLQWDHLIGMGSFLLWAMHMRWTVEQQSSFLQTCYLALKVGVLCLISGPCGAAVWLLWEESQF
What is the function of this protein?
Hydrolase; part of the gene cluster that mediates the biosynthesis of citreoviridin, an inhibitor of the of F1-ATPase beta-subunit (PubMed:26954888).  The HR-PKS ctvA accepts acetyl-CoA as the starter unit and catalyzes eight iterations of malonyl-CoA extension and four iterations of SAM-dependent methylation at C4, C12, C14, and C16 (PubMed:26954888).  The KR and DH domains selectively act on the first six iterations to generate the hexaene chain (PubMed:26954888).  In the last three iterations, the KR and DH domains terminate their functions to yield a beta,delta-diketo ester moiety, which then undergoes intramolecular cyclization to yield an alpha-pyrone intermediate (PubMed:26954888).  Subsequently, ctvB methylates the alpha-pyrone hydroxyl group to generate citreomontanin (PubMed:26954888).  In order to form the tetrahydrofuran ring with the correct stereochemistry, the terminal alkenes of citreomontanin need to undergo isomerization to yield a (17Z)-hexaene, a step that could be catalyzed by ctvC (PubMed:26954888).  The (17Z)-hexaene then undergoes bisepoxidation by ctvC to form a (17R,16R,15S,14R)-bisepoxide moiety (PubMed:26954888).  Lastly, ctvD acts as a regioselective hydrolase to form the tetrahydrofuran ring with the substituents in the correct absolute configuration, completing the biosynthesis of citreoviridin (PubMed:26954888).
What are the official names of this protein?
Terpene cyclase ctvD, Citreoviridin biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound ascI terpene cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y2779_YERPS
Sequence: MAALDPTLLILLALAALGILSHNMTVTLAILILIAIRITPLNSFFPWVEKYGLTIGVLILTIGVMAPIASGKISASEVLHSFVQWKSILAIVVGVAVSWLGGRGVSLMTHQPSVVAGLLVGTVLGVALFKGVPVGPLIAAGLLSLVIGKS
What are the official names of this protein?
UPF0756 membrane protein YPTB2779.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNAA_ZYMMO
Sequence: MQPPSQDWASLLPAAWSEARQILRKKCGSRTFESWLKSLMLADFDSQKKIIRLACPSEFMANWISSHLSDELLLAWRTVWPGIAEVKVSVRNPESQPLLLDVTEIELPLGDQPRPLPKKPAKKKQSVPATPKSTSPEKKAEGEDQNQFEERYNFDNFVVGKANDLAYRAACTFAEGGKLDFNPLFLYGGTGLGKTHLMHAVGIEYLKRHPNSTALYMSAEKFMYDFVASMRAKDTHSFKARLRSADLLMIDDVQFIAGKDSTQEEFFHTMNEVITAGRRLVISADRSPQDLERIESRILSRLSWGLVADVNPADFELRLNIILKKLEAMPQVSMPEDIVFFLAKRICTNVRELEGALNRVVAYATLSNRPINMDFVTETLADLLRTTQQRVTVEDIQKRVCDHYHLKLADMSSKRRDRVIARPRQVAMYLSKQLTSRSLPEIGQRFGGRDHTTVIHAIRQIEKLRITDEDVDSDVRLLMRQFEG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.