PharMolix/UniProtQA huggingface dataset:
Protein: 3SA4_NAJAT
Sequence: MKTLLLTLVVVTIVCLDLGYTRKCNKLVPLFYKTCPAGKNLCYKMFMVSNLTVPVKRGCIDVCPKNSALVKYVCCNTDRCN
What is the function of this protein?
Basic protein that bind to cell membrane and depolarizes cardiomyocytes.  This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2.  It binds to the integrin alpha-V/beta-3 with a moderate affinity.  Inhibits protein kinase C.  It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes.  It may also target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.
What are the official names of this protein?
Cytotoxin 4, CTX-4M, CTX4, Cardiotoxin A4, CTX A4, Cardiotoxin analog IV, CTX IV.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: RS8_BURMS
Sequence: MSMSDPIADMLTRIRNAQMVEKVSVSMPSSKVKVAIAQVLKDEGYIDDFAVKADGAKAELNIALKYYAGRPVIERLERVSKPGLRVYRGRNEIPQVMNGLGVAIVSTPKGVMTDRKARATGVGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: YAEH_ECODH
Sequence: MYDNLKSLGITNPEEIDRYSLRQEANNDILKIYFQKDKGEFFAKSVKFKYPRQRKTVVADGVGQGYKEVQEISPNLRYIIDELDQICQRDRSEVDLKRKILDDLRHLESVVTNKISEIEADLEKLTRK
What are the official names of this protein?
UPF0325 protein YaeH.
What is the protein family that this protein belongs to?
Belongs to the UPF0325 family.
Protein: 3HAO_CAEBR
Sequence: MAGVTAIEIPQWIQDNQGDFVPPVCNKCMFSDQLKVFYVGGPNQRKDFHLEEGEEFFFQRKGDMVLKVIEKGQVRDLVIKQGEMFMLPARVEHSPQRFANSIGLVVERERKNTEFDCVRFLVGSSNVTLFERWFFLTDVVKDLPPLIKEFYNSNEFKTGKPGKGTFACNAPYEARWTDLPVPINRKEFIYDHISEVKNGPVKIYGAPEYKTEVMLLGEGSYDLEAGAVELIIWLQENTFAVVEESGFTYALKSETMVRIKPNTKCLLNVKGGFAITIRMPG
What is the function of this protein?
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
What are the official names of this protein?
3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HAD.
What is the protein family that this protein belongs to?
Belongs to the 3-HAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_RHILO
Sequence: MARVKRGVTSHAKHKKVLKAAKGFYGRRKNTIRIAKQAVEKSLQYAYRDRKNRKRSFRALWIQRINAATHEHGLTYGRFIDGLNKAGIEIDRKILSDMAIHEPQAFAALVAKAKVALEYLKNTTPNAFESAVA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SODC2_BRAJU
Sequence: MGKGVAVLNSSEGVKGTIFFAQEGEGKTTVTGTVSGLKPGLHGFHVHALGDTTNGSMSTGPHFNPDGKQHGAPEDANRHAGDLGNIIVGDDGTATFTITDCQIPLSGPNSIVGRAVVVHADPDVLGKGGHELSLTTGNAGGRVACGIIGLQG
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn] 2.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADJ_ECO24
Sequence: MEMASVFTLNVRLDNIAIITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDNFIAGADINMIGNCKTAQEAEALARQGQQLMAEIHALPIPVIAAIHGACLGGGLELALACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALKLGLVDDVVPHSILLEVAVELAKKDRPSSRPLPVRERILAGPLGRALLFKMVGKKTEHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTEVKKDPGSDAPPAPLNSVGILGGGLMGGGIAYVTACKAGLPVRIKDINPQGINHALKYSWDQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQNCAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATTVKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTEGERVEHIDAALVKFGFPVGPIQLLDEVGIDTGTKIIPVLEAAYGERFSAPANVVSSILNDDRKGRKNGRGFYLYGQKGRKSKKQVDPAIYPLIGAQGQGRLSAPQVAERCVMLMLNEAVRCVDEQVIRSVRDGDIGAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVEMGARGESFWKTTATDLQ
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_ROSDO
Sequence: MNDPIADMLTRIRNSQLRGKSTVITPASKLRAWVLDVLADEGYIRGYEKITGADGHPAIEISLKYYEGEPVIRELKRVSKPGRRVYMGVNDIPVVRQGLGVSIVSTPKGVMSDQAARSANVGGEVLCTVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: RL18A_META3
Sequence: MPKIYRIKGKIVGKDEPMVFTKEYKAMKEEDAIEKIYSEIGSKHNVKRASIKIIEVSEISADEVQDPILQAVL
What are the official names of this protein?
50S ribosomal protein L18Ae, 50S ribosomal protein L20e, 50S ribosomal protein LX.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: RLMM_XANCB
Sequence: MSGLLCYCRQGFEPELAAELSARAAFVGIAGYARTQRNDGYVLFVCDEAAQLAARLQWRELIFARQKLVVLAELKGLDPKDRITPILAALDGQPRFGDLWVEHPDSDAGKPLAGLARSFGNALRPALRKAGLLTDKPQARLPRLHICFLDGDHALLAVADSSDSAPWPLGIPRLKLLPEAPSRSALKLDEALLTLLTPEEREQLVKPGMRAADLGAAPGGWTWVLTRQHVHVTSVDNGPLREHVLATGLVEHLRADGFHWKPAQPLDWMVCDMVEQPRRVAERMATWVREGWCRHTIFNLKLPMKKRWDETRLCLDLFEQQAEKSLTVRAKQLYHDREEITVLAMRG
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GEAS_LAVVI
Sequence: MAQQEAEILRPLANFSPSLWGDQFIKNDSDAKVRYIFHYVDYTNLSMLTATGTKMVDTMNLIDTLERLGVSYHFEHEIEEILQQFFNLNTDYNDEAYDLYTVATHFRLFRQHGHRITCADIFGRWRDENGKFHEGLKDDAKGLLSLYEASYLRTRGETILDEALDFTTASLKSIAPNLESPLRRQVEHALVQQLHWGNPRIEARNFISLYEEYEDKDESLLRFAKLDYNLLQMMHKEELHEVSRWWKELDLVAKLPYARDRVVECFFWAMGVYHEPQYSRARVMLTKTIAMTSIIDDTYDAYGTIEELDIFTEAIERWNVEEMKRLPEYIKPFYKALLELYEQFEEELAKEGRSYATHYAIESLKELVRSYHVEAKWFIQGYLPPFEEYLKNALITCTYCYHTTTSLLGVESAVREDFEWLSKKPKMLVAGLLICRVIDDIATYEVEKDRGQIATGIESYMRDNGATKEEAITKFFEIANDAWKDINEECMRPSPHSRDVLMRILNLERIIDVTYKGNEDGYTQPEKVLKPHIIALFVDPIQI
What is the function of this protein?
Sesquiterpene synthase involved in the biosynthesis of volatile compounds widely used in aromatherapy and folk medicine, and present in culinary herbs (PubMed:24943828).  Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into germacrene A and beta-elemene (PubMed:24943828).  Not able to use (2E)-geranyl diphosphate (GPP) as substrate (PubMed:24943828).
What are the official names of this protein?
Germacrene A synthase, LvGEAS, Beta-elemene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsa subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y116_OSHVF
Sequence: MAAVALTYMIPPATPLAIIDFDMLPEDDESEEVGFEYEDLLDWQLKEAVDRRDLESFTILIEENWCHDLTLENGDNLLGYMIKQGHALTEEWYDLIGVTTTCHANPEGELPIDLLRKHLGSCRCNLESMNCDLVEYIIRTCYAHPINRDYVYHRMDTSRYTHKRLNRNHNLTLSIEKKPIIVEAPPMEEEEISEVEDALNVLQRLCAQEEGDNKEAETNNNNYVFPWMTPAYELPEQLTFYDMPMTPFNCNNVMYC
What are the official names of this protein?
Uncharacterized protein ORF116.
Protein: HIS8_LEPBL
Sequence: MIQFQPVLGSLKSYEAGKPIELVVREFGIDPDQIIKLGSNENPFGCAQPVVEAVQKAASKMPYYPDDSYLELKTALASKFDLTPDRIILGNGSDQVLDFACRCVLGPGDSILINRITFAMYRIYALQCGAKVHSTETVLHDLNAFLDLAKSIRPKIIFLCTPSNPIGDALFKSDVYDFLRQIPSNTLVVIDAAYMEFGKKKDSNTFISAKEVTDLFPNVFYTGTFSKAYGLGGMRIGYGIGSKELISNLYKMRPPFNVANLSALAATEALKNESHVESYLDNNLKEMKRYEKFAAEQSVEFIDSYANFITFFARKRGKSSTEISQSLLKQGIILRNLRSYDLNAIRITIGKPQQNDRVLTALNQEFS
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: PLOD2_RAT
Sequence: MGDRGVRLGLLMPMLALLSWAASLGVAEETPSRIPADKLLVITVATKENDGFHRFMNSAKYFNYTVKVLGQGQEWRGGDGMNSIGGGQKVRLMKEAMEHYAGQDDLVILFTECFDVIFAGGPEELLKKFQKTNHKIVFAADALLWPDKRLADKYPGVHIGKRYLNSGGFIGYAPYISRLVQQWNLQDNDDDQLFYTKVYIDPLKREALNITLDHRCKIFQALNGATDEVVLKFENGKSRVKNTFYETLPVAINGNGPSKILLNYFGNYVPNSWTQENGCALCDFDASDLSTVDVYPKVTLGVFIEQPTPFQPRFLDLLLTLDYPKEALRLFVHNKEVYHEKDIKAFVDKAKHDISSIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGIWNVPYMANVYLIQGKTLRSEMSERNYFVRDKLDPDMSLCRNARDMGVFMYISNRHEFGRLISTANYNTSHLNNDLWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSERACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQIDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP
What is the function of this protein?
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens.  These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
What are the official names of this protein?
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, Lysyl hydroxylase 2, LH2.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: EFTS_ALKMQ
Sequence: MSITAAMVKEIREKTGAGMMDCKKALTEASGNMEKATEILREKGLAAVAKKAGRIASEGIVESYIHGGRIGVLVEVNSETDFVAKNQEFKDFVKDVAMHIAATNPQYVKRDEVDPLIIEKEKEFLTKQALNEGKPEKIVEKMVEGRIDKFLKEICLLDQPFVKNPDVTIGDLLTEKIAKIGENLSIRRFVRFEVGEGIEKKEENFAEEVAKQMAK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_STRZJ
Sequence: MKVIDQFKNKKVLVLGLAKSGESAARLLDKLGAIVTVNDGKPFEDNPAAQCLLEEGIKVITGGHPLELLDEEFALMVKNPGIPYSNPMIEKALAKGIPVLTEVELAYLISEAPIIGITGSNGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQVAQIASDKDTLVMELSSFQLMGVQEFHPEIAVITNLMPTHIDYHGLFEEYVAAKWNIQNKMTAADFLVLNFNQDLVKDLASKTEATVVPFSTLEKVDGAYLEDGQLYFRGEVVMAANEIGVPGSHNVENALATIAVAKLRDVDNQTIKETLSAFGGVKHRLQFVDDIKGVKFYNDSKSTNILATQKALSGFDNSKVVLIAGGLDRGNEFDELVPDITGLKKMVILGQSAERVKRAADKAGVAYVEATDIADATRKAYELATQGDVVLLSPANASWDMYANFEVRGDLFIDTVAELKE
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCX3_ARATH
Sequence: MSAVSFLYSSKTPKFRGVFNGICALVLFCFFFDRSELLRNPLLRNASFVNGGSGSTSGGITQFMVIRRNARQIETNGSGNNSSLSSSSTVLCSGLHKHMGYADQCEFLKANPICSPDGFFDYLSFFYCSCRDFSILGYMMLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGTDKGEVGLNSVLGGAVFVTSVVVGIVSLCVADKEVKIDKNCFIRDLSFFLFSLVSLLVILMVGRVTVRIAIAFVSIYVVYAFLVAANVILRKHAKRFKLEALTPLLPMQGSVFSPSVGEDMPMNTPLIETETEDGPPRLQSLPQWMWASNVAIYSNHFAKVSVHDEDRPPWGWIDDTAEVESSSCTKFTSLLEIPLTIPRRLTIPSVEEDTWSKTYAVASVSLAPVLLASLWSSQDDVSLQACGVAYFFSVVIGSTLGFLAYKNTEPDHPPRRFLIPWVLGGFIMSIVWFYMIANELVALLVTFGEIYGINPSILALTVLAWGNSMGDLVSNIALTMNGGDGVQIALSGCYAGPMFNTLVGLGMSMLFGAWSKSPDTYMLPEDKSLFYTLGFLVLGLVWAMVILPRNDMQPSRTLGVGLIAIYLIFVTFRLSCAMGFIPWAA
What is the function of this protein?
Endomembrane-localized H(+)-dependent K(+) and Na(+) transporter.  May have a function associated with the pollen vacuole during tube elongation and polarized top growth.
What are the official names of this protein?
Cation/calcium exchanger 3, AtCCX3, Protein CATION CALCIUM EXCHANGER 3, Protein CATION EXCHANGER 9.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/calcium exchanger (CCX) subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
Protein: RFCS_METST
Sequence: MKTPWVEKYRPQTLDDVVGQEQIVGRLKRYVEEKSLPNIMFTGFAGVGKTTCALALAKSLLGEYWQQNFLELNASDARGIDTVRNEIKSFCKLKAVGAPFRIIFLDEVDNMTKDAQQALRREMEMYTKTSSFILSCNYSSKIIDPIQSRCAIFRFSPIKAANIIKRLKYIASEEGIEAEQSALENIVYFTQGDMRKSINILQASTTTENTVTEEAVYDVISRAKPKDVRKIINKALNHDFMEARDLLRDIMIIEGVSGDDLITQFYQEVAQMTQEELIPEVEFIKLMEYMSECDYRIREGSNPRLQLEALLSKFLLVKQDA
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C small subunit, RFC small subunit, Clamp loader small subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: UNG_STAEQ
Sequence: MKWSEVFHDITTRHDFQAMHDFLEKEYTTQIVYPDKKNIYQAFDLTPFEDIKVVILGQDPYHGPNQAHGLAFSVQPHAKFPPSLRNMYQELENDIGCHRTSPHLQDWAREGVLLLNTVLTVRQGEAHSHRNIGWETFTDEIIQAVSNYREHVVFILWGRPAQQKERFIDTSKHLIIKSPHPSPLSAFRGFFGSKPYSTTNNYLKSKGKTPVQWCES
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX29_PHONI
Sequence: SFCIPFKPCKSDENCCKKFKCKTTGIVKLCRW
What is the function of this protein?
Blocks voltage-gated sodium channels (Nav).  Causes tail erection, scratching and a reduction in mobility at a dose level of 1. 40 mg/mouse.
What are the official names of this protein?
U5-ctenitoxin-Pn1a, U5-CNTX-Pn1a, Neurotoxin Tx2-9.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 60 (Tx2-9) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MKX_PONAB
Sequence: MNTIVFNKLSGAVLFEDGGASERERGGRPYSGVLDSPHARPEVGIADGPPLKDNLGLRHRRTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGPQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDDSCSEGGENPPRTHMNEGGYNTPVHHPVIKSENSVIKAGVRPESRASEDYVAPPKYKSSLLNRYLNDSLRHVMATNTTMMGKTRQRNHSGSFSSNEFEEELVSPSSSETEGNFVYRTDTLENGFNKGDSAANRKGPSKDDTYWKEINAAMALTNLAQGKDKLQGTTSCIIQKSSHIAEVKTVKVPLVQHF
What is the function of this protein?
May act as a morphogenetic regulator of cell adhesion.
What are the official names of this protein?
Homeobox protein Mohawk.
What is the protein family that this protein belongs to?
Belongs to the TALE/IRO homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1233_HAEI8
Sequence: MTLQLNTIALLLVILLILGVLSNNSAITISAAVLLIMQQTFLSSHIPLLEKYGVKIGIIILTIGVLSPLVSGKIQLPDLSGFLSWKMALSIAVGVLVAWLAGKGVPLMGEQPILVTGLLIGTIIGVAFLGGIPVGPLIAAGILALLLGKI
What are the official names of this protein?
UPF0756 membrane protein NTHI1233.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: A1KB2_LOXSA
Sequence: WIMGHMVDAIAQIDEFVSLGANSIETDVSFDKNANPEYTYHGIPCDCGRTCTKWEYFNTFLGGLRKATTPGDSKYHEKLVLVVFDLKTGSLYDNQAYDAGTKLAKSLLQNYWNKGNNGGRACIVLSIPNLDHYKLITGFKETLTKEEHPELMDKVGYDFSGNDDIGDVAKAYKKAGVTGHVWQSDGITNCLLRGLDRVRKAVANRDSSNGYINKVYYWTVDKRASTRDALDAGVDGIMTNYPDVIADVLSESAYTAKFRIATYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LsaSicTox-alphaIB1bii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLO2_HAEIN
Sequence: MLFALPALNDNYIWLYQRENLPLIIVDLPETDKLFAWLEKQNATIEAVLLTHEHDDHTQGVSAFKKRYPTVPIYGPQECEKKGATQIVNEGKILTANYQIDVIPTGGHTKQHVSFLVDNHLFCGDALFSAGCGRVFTGNYALMFEGLQRLNTLPDETIVCPAHEYTLGNLAFAETVLVDKSAVEKSAVEKQRIFVETQRAENKPSLPTTLKLEREINPFLQAKTLEEFTALRKAKDIF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: PXG1_AVESA
Sequence: MAEDAVVSDAVVVSDAMSSVAKGAPVTAQRPVRDDLEKHIPKPYLARALVAVDVNNPEGTKGGRHEHGQKSVLQQHVSFFDQNGDGIIYPWETFRGLRRLGFNLIVSFIVAIGIHTGLSYPTLPTWRPSLLFPVYIDRIHKAKHGSDTATFDTEGRFMPVNFENIFSKNARSQPDKLTLREIWMMTNDHRLAYDPFGWVANKGEWILLYMLAKDDEGYLPKEAIRGVYDGSLFEFLAEQRTKKAHGKQH
What is the function of this protein?
Calcium-binding peroxygenase involved in cutin monomers biosynthesis.  Can catalyze epoxidation of fatty acid and sulfoxidation reactions that can proceede competitively, although in favor of the sulfoxidation.  Can only use unsaturated fatty acids with double bonds in the cis configuration as substrates.  The preferred substrate is oleic acid and is inactive toward ricinoleic acid.  Free fatty acid and fatty acid methyl esters are effective substrate forms, but not phospholipids and acyl-CoA.  Hydroperoxy-trienoic (HPOT) acids are preferred over Hydroperoxy-dienoic (HPODT) acids as oxygen donors.
What are the official names of this protein?
Peroxygenase 1, AsPXG1.
What is the protein family that this protein belongs to?
Belongs to the caleosin family.
What are the subcellular locations of this protein?
Microsome membrane. Lipid droplet.
Protein: TPF_PELSA
Sequence: FLGTINLSLCEEERDADEEERRDEPDESNVEVKKRFFFLSRIFGK
What is the function of this protein?
Non-amphipathic alpha-helical antimicrobial peptide with potent activity against some Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)), weak activity against Gram-negative bacteria and no activity against fungi (PubMed:20308076, PubMed:26181487, PubMed:27915018).  Permeabilizates membranes through a detergent-like effect probably via the carpet mechanism (PubMed:20308076).  More precisely, it strongly and selectively perturbs anionic bilayers membranes by interacting with the polar headgroups and the glycerol backbone region of the phospholipids, hence disrupting the acyl chain packing of the bilayer (PubMed:20308076).  Is not active against Leishmania (promastigote and axenic amastigote forms) (PubMed:20308076).  Does not show hemolytic activity (PubMed:20308076, PubMed:26181487).  Does not show toxicity for human THP-1-derived macrophages (PubMed:26181487).
What are the official names of this protein?
Temporin-SHf, Temp-SHf, Phe-rich antimicrobial peptide.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Inserts into the lipid bilayer with an in-plane (parallel) orientation.
Protein: BZAB_EUBLI
Sequence: MTQMLEARKGHITEEMEKVALIEGVTPEFVREGVAKGHIVIPKNKFRSRDKICGIGGGLDVKVNGLMGTSSDRNDMEMEAKKLRILEECGANAFMDLSTGDDIDAMRKQSLTISNIAAGCVPVYQASVEAIEKHGSMVGMTEDELFDTVEKQCQEGMDFMAIHSALNWSVLNALKKSGRVTDVVSRGGSFLTAWMFHNKKENPLYEHFDRLLEILKATDTVLSIGDAIRPGANADSLDSAQVQGLIVAGELTKRALEAGVQVMIEGPGHVPLNQIATTMQLQKQLCYGVPYYILGFLATDVAPGYDNITGAIGGAFAGMHGADFLCYLTPAEHLGLPNEDDVRMGVRTTKIAADAANVLKRGGNAWNRSLAMSKARVARDEKVQVANALDPEYLESKLKAEPESHGCAACGKSKCPADVAAEFFGIA
What is the function of this protein?
Together with BzaA, catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.  Is thus involved in the anaerobic biosynthesis of dimethylbenzimidazole (DMB), the lower axial ligand of vitamin B12 (cobalamin).  Requires BzaA for catalytic activity, as BzaB alone displays no activity.
What are the official names of this protein?
5-hydroxybenzimidazole synthase BzaB, 5-OHBza synthase, HBI synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.
Protein: WNT2_FELCA
Sequence: MNAPLGGIWPWLPLLLTWLTPEVSSSWWYMRATGGSSRVMCDNVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAVSSAGVVFAITRACSQGELKSCSCDPKKKGTAKDSKGNFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDRDAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCKAPKSVDWAAPT
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity).  Functions as upstream regulator of FGF10 expression.  Plays an important role in embryonic lung development.  May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
What are the official names of this protein?
Protein Wnt-2.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: ENDO1_BPT5
Sequence: MGYYSVGIPFLYFKIPFTNSIRLCILYSLIGRTSPIIERKQEKLMLYMGVGDSMGRQKLTIKDINIRLADRGIQIVGEYVNQRTKTVFKCQRAHVWEATPHSILHMRRGCPHCSNNTISLDEVSNRISNIGYTLLSSYTNAKTKLHLRCNNGHDCFITLDGLTQGKRCPYCSLKWENGGFLYIMSFSSGTKVGISLYPEKRLNEVKRESGFSDLYLFTMYHLPDRETALDLEKEVHREYYNKNCGFSNFTGSTEFFNVAPEDIVIFLNSFGLEEYGH
What is the function of this protein?
Putative endonuclease.
What are the official names of this protein?
Putative endonuclease.