PharMolix/UniProtQA huggingface dataset:
Protein: RPOB_FRATN
Sequence: MSYSYAEKKRIRKEFGVLPHILDVPYLLSIQTESYKKFLTADAAKGRLHSGLEIVLKQSFPVESKNGQYELHYVDYQIGEPTFDETECQVRGATYDAPLNVKLRLVVYNKDALPNEKIVEDIREEYVYMGDIPLMTTNGTFIINGTERVVVSQLHRSPGVFFSKDDSEEGAFSARIIPYRGSWLDFEFDSKGIIWARIDRKRKFCATVILKALGYTQEQILENFSETKTITFNSKGFALRLDNLSNMKGELLKFDIVDAQDNVIVKKNKKLTSRDVKKIKDAGVDSVAIDFDLVSTLRVAKDIVNEATGEVIAYANDDVTESLLESCVEVGMLELEVIDFITTERGRYISDTLKYDLTRNTDEALVEIYKVLRPGDPPAAASVKALFEGLFFIESRYSLSDIGRMKLNARLGSDKVSKDIYTLENSDIVGVIEELINIRDGKGKVDDIDHLGNRRVRSVGEMVENQFRIGLYRVEKGIRESMSLVHKDKLMPKDIVNSKPITAAIKEFFTSGALSQFMDQDNPLSEVTHKRRISALGPGGLSRDRAGFEVRDVHATHYGRLCPIETPEGPNIGLINSLASYARVNDYGFLEAPYRKVVDGKVTDEIEYLSAIDEDNYVIAQASTKLDENNHFVEDLIQCRSGGEAIFTESSRVQYMDVSAKQMVSAAAALIPFLEHDDANRVLMGANMQRQAVPTLKSEKPLVGTGMEKIVARDSGNCIIARNAGEVAEVDSNRIVIKVDTEKSQTSNLVDIYSLTKFKRSNKNTCINQRPIVNVGDKVEAGDILADGFATDFGELSLGHNLMVAFMPWNGYNFEDSILLSERIVKDDKYTSIHIEEFTCVARDTKLGPEEITADIPNVSESSLAKLDESGIVHIGANVEAGDILVAKITPKAEQQLTPEERLLRAIFNEKASNVADSSLRMPSGTSGTVINVQVFENDKGGKSKRALKIEKELIDKARKDFDEEFAVIESVVKSSIEQEVVGAKIQKAKGLKKGAILTKEFLATLPFSKWLEISFEDEKLEEKVQNAREYYEEAKIAIDAKFEAKKKSITQSNELSPGVLKTVKVFVAIKKRIQPGDKMAGRHGNKGVVSRVLPVEDMPYMEDGTPVDVCLNPLGIPSRMNIGQILEAHLGLASYGLGKKIEKTLEKTRKAAELRKTLEEVYNSVGDKKVNLEALNDEEILTLCDNLKGGVPIATPVFDGAKEEDIKSLLKIGGFATNGQMKLFDGRTGKPFDRHVTVGYMYMLKLDHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALQAYGAAYTLREMLTVKSDDIAGRSKMYKNIVDGKLTMNVDVPESFNVLRNEVRALGIDMDFDYSSEEE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RR10_PORPU
Sequence: MTVTQQPKIRIKLKAYNSSLLNTSCKKIVDTAERTNAIAVGPIPLPTKRRIYCVLRSPHVDKDSREHFEIRSHRRIIDIHQPSSQTIDALMKLNLPSGVDIEVKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PHNC_BDEBA
Sequence: MIVSEPLLRVENLSKTYPNGVQALKNINLEVHPGEFLVVIGLSGSGKSTLLRCLNRLQEPTSGNIYFSGQEIGQVQDAEKIRSVRSKMAMIFQHFNLIPRQSVLKNVLMGRLAAKSTWQSLWGMFSDAERIEAKENLRLVGIAEKASLRADQLSGGQKQRVAIARALMQKPVLLLADEPVSSLDPATCHVVMDYLRRINQEMGITVIANLHFLSLVRKYATRVVALKDGEIVFRGKPEEITEEWFRRIYGEGAQDVAPNDI
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PURT_SHIF8
Sequence: MTLLGTALRPAATRVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMHVAHRSHVINMLDGDALRRVVELEKPHYIVPEIEAIATDMLIQLEEEGLNVVPCARATKLTMNREGIRRLAAEELQLPTSTYRFADSKSLFREAVAAIGYPCIVKPVMSSSGKGQTFIRSAEQLAQAWEYAQQGGRAGAGRVIVEGVVKFDFEITLLTVSAVDGVHFCAPVGHRQEDGDYRESWQPQQMSPLALERAQEIARKVVLALGGYGLFGVELFVCGDEVIFSEVSPRPHDTGMVTLISQDLSEFALHVRAFLGLPVGGIRQYGPAASAVILPQLTSQNVTFDNVQNAVGADLQIRLFGKPEIDGSRRLGVVLATSESVVDAIERAKHAAGQVKVQG
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: SYN2_HUMAN
Sequence: MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPPPPPGPGAASASAAPPTASPGPERRPPPASAPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPAPAAARKAKVLLVVDEPHADWAKCFRGKKVLGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLVAIYKTLGGEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDSKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKDPDSSKTPPQRPPPQGGPGQPQGMQPPGKVLPPRRLPPGPSLPPSSSSSSSSSSSAPQRPGGPTTHGDAPSSSSSLAEAQPPLAAPPQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD
What is the function of this protein?
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release.  May play a role in noradrenaline secretion by sympathetic neurons (By similarity).
What are the official names of this protein?
Synapsin-2, Synapsin II.
What is the protein family that this protein belongs to?
Belongs to the synapsin family.
What are the subcellular locations of this protein?
Synapse.
Protein: ULAR_ECOL5
Sequence: MTEAQRHQILLEMLAQLGFVTVEKVVERLGISPATARRDINKLDESGKLKKVRNGAEAITQQRPRWTPMNLHQAQNHDEKVRIAKAASQLVNPGESVVINCGSTAFLLGREMCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSPQGSENSLYAGHWMFTSGKGLTAEGLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNANPEILQQLEAQGVSILRV
What is the function of this protein?
Represses ulaG and the ulaABCDEF operon.
What are the official names of this protein?
HTH-type transcriptional regulator UlaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTMA_STAAS
Sequence: MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II CmtAB PTS system is involved in D-mannitol transport.
What are the official names of this protein?
Mannitol-specific phosphotransferase enzyme IIA component, EIIA, EIII, PTS system mannitol-specific EIIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 4HBDH_CUPNE
Sequence: MAFIYYLTHIHLDFGAVSLLKSECERIGIRRPLLVTDKGVVAAGVAQRAIDAMQGLQVAVFDETPSNPTEAMVRKAAAQYREAGCDGLVAVGGGSSIDLAKGIAILATHEGELTTYATIEGGSARITDKAAPLIAVPTTSGTGSEVARGAIIILDDGRKLGFHSWHLLPKSAVCDPELTLGLPAGLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERGWGHIERATRDGQDRDARLNMMSASMQGAMAFQKGLGCVHSLSHPLGGLKIDGRTGLHHGTLNAVVMPAVLRFNADAPTVVRDDRYARLRRAMHLPDGADIAQAVHDMTVRLGLPTGLRQMGVTEDMFDKVIAGALVDHCHKTNPKEASAADYRRMLEQSM
What is the function of this protein?
Involved in the degradation of 4-hydroxybutyrate (PubMed:7851418).  Catalyzes the interconversion of gamma-hydroxybutyrate (GHB) and succinic semialdehyde (SSA) (PubMed:31981617).
What are the official names of this protein?
4-hydroxybutyrate dehydrogenase, 4HbD, Gamma-hydroxybutyrate dehydrogenase, GHBDH.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
Protein: TEKT1_HUMAN
Sequence: MAKLLQPPPKFLPSEWHIANKNQYHRADAQRSRSERLVAESQRLVDEIEKTTRKSQSDVNKKLEQRLEEVQFWKKELDDKLEQLVNVTDDLLIYKIRLEKALETLKEPLHITETCLAYREKRIGIDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMNRSAKYNLEKDLKDKFVALTIDDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWLDFSSTNVEKADKQRNNSLMLKALVDRILSQTANDLRKQCDVVDTAFKNGLKDTKDARDKLADHLAKVMEEIASQEKNITALEKAILDQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEITHNVARLKETLAQAQAELKGLHRRQLALQEEIQVKENTIYIDEVLCMQMRKSIPLRDGEDHGVWAGGLRPDAVC
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme.  Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
What are the official names of this protein?
Tektin-1.
What is the protein family that this protein belongs to?
Belongs to the tektin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: RUVB_STRPZ
Sequence: MARILDNNVMGNEEFSDRTLRPQYLHEYIGQDKVKEQFAIFIEAAKRRDESLDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAVEKAGDLVAILNELEPGDILFIDEIHRMPMSVEEVLYSAMEDFYIDIMIGAGDTSRSIHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYQEKDLTEIVERTATIFEIKIDHEAARKLACRSRGTPRIANRLLKRVRDYAQIIGDGIITAQITDRALTMLDVDREGLDYIDQKILRTMIEMYQGGPVGLGTLSVNIAEERNTVEEMYEPYLIQKGFLMRTRTGRVATQKAYRHLGYPYQNT
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PDXT_FRATT
Sequence: MTQKVGVLAIQGGYQKHADMFKSLGVEVKLVKFNNDFDSIDRLVIPGGESTTLLNLLNKHQIFDKLYNFCSSKPVFGTCAGSIILSKGEGYLNLLDLEVQRNAYGRQVDSFVADISFNDKNITGVFIRAPKFIVVGNQVDILSKYQNSPVLLRQANILVSSFHPELTQDPTIHEYFLAM
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: MURI_ECOLI
Sequence: MATKLQDGNTPCLAATPSEPRPTVLVFDSGVGGLSVYDEIRHLLPDLHYIYAFDNVAFPYGEKSEAFIVERVVAIVTAVQERYPLALAVVACNTASTVSLPALREKFDFPVVGVVPAIKPAARLTANGIVGLLATRGTVKRSYTHELIARFANECQIEMLGSAEMVELAEAKLHGEDVSLDALKRILRPWLRMKEPPDTVVLGCTHFPLLQEELLQVLPEGTRLVDSGAAIARRTAWLLEHEAPDAKSADANIAFCMAMTPGAEQLLPVLQRYGFETLEKLAVLG
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: DPO3B_CHLTR
Sequence: MNFRLHGAFSNPSFVKIFFTKASPERRLTCFHVTKHGYSFQTDLHDYRKIMKFVISRNELGNLIKKVQNVVPQSTPIPVLTHVLIESCNDELVFTATDLTVSTRCVVKAKVYESGSVTIPSRRFFQLIRELTEANIEVAAHSGEMATITSGSSCFRLLSMGKEDFPMLPDMQNALRFTLDSERLKDMFQRTSFAVSREESRYVLTGVLLSIANGTMTVVGTDGKRLAKIDTEISLDPSFSGDYIIPIKAVEEIIRMSSEDVQSTIFLDQTKIAVECGNTLLVTKLLSGEFPDFSPVISTHSSVQLDLHREELISLLKQVALFTNESSHSVKFSFSPGELTLTANCTKVGEGKVSMAVNYTGETLEIAFNPFFFLDILKHSRDELVQLGISDSYNPGIITDSTRSLFVIMPMRLHDD
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCD57_MOUSE
Sequence: MLPLCSERELNELLARKEEEWRVLQAHRAQLQEAALQAAQNRLEETQGKLQRLQEDFVYNLQVLEERDRELERYDVEFTQARQREEAQQAEASELKIEVAKLKQDLTREARRVGELQHQHQLMLQEHRLELERVHSDKNSELAHQREQNERLEWELERKLKELDGELALQRQELLLEFESKMQRREHEFQLRADDMSNVVLTHELKIKLLNKELQALRDAGARAAESLQKAEAEHVELERKLQERARELQDLEAVKDARIKGLEKKLYSAQLAKKKAEETFRRKHEELDRQAREKDTVLAAVKRAHAEELQTLDAKVLELQFLCETLEGQLRRAECTRAEDAKEKNALTDKFREDAAALKAAWDAQITQMSKETVSKDFQIHTLQEEEMKLKAQVARFQQDIDRYKQQLSLAVERGQSLEREQVQLGLDWQRRCDDIERDQIQKSETLIEGLTKARDQVAAKLQETEKALRQQETLLKAVSLERDQAMETLRTHGLLPGQEAQVPPQQHEGEIRADSPSTEIQRLQEQNAGLRNAVSQMRREMEMLSGHLPPAQPEECSNADPDPKAGGDSTPPDYVLTLEAEMQNLKHKLKALEEQLQSTEEPVKTSVATADPHHGVHSSAAAADAALADQTSTALALRKLGDRVHLLNLLVTQLKRKLRQKPRELVPVQHEVPSEVDQVHLEVLELQKQVAELRKHLKVTPQGEPSSREQLQRQGVADRYPMGMEDQTESPTFPQEGAQPPQTIYVTHLQRKLKDAARKILSLRLEREQLLEMGNRLRAEQGHAKGKPTPCPGPPTSEPQDPQEVPERSLDRGPPLGQLQPYSTTQDPRHTKRRCASEYAGKSQPHSAQVGSKTNTPRGHKAEMASRPAQLSQKQHRIPTETWKPVYQKENRTPKLPQAHEVPEESDHRTHRSSSLASSSLQDIWRLLELGSSPSGVPSQDNSVAECPAPSRPSCFQKVNRSPVPIQKAFAVKGLKMEAQPKATPPRPSKSHPAKPTNCQQQRPSRIRNYNLKD
What is the function of this protein?
Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis (PubMed:32402286).  Critical interface between centrosome and microtubule-mediated cellular processes.  Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome.  Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression (By similarity).
What are the official names of this protein?
Coiled-coil domain-containing protein 57.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Note=Localizes to resolvable rings at the proximal end of centrioles. In mitotic cells, localizes to spindle microtubules during metaphase.
Protein: END4_SALAR
Sequence: MKYIGAHVSAAGGLANAPARAAEIGATAFALFTKNQRQWRAAPLIPQVIDDFKIACEKYHFSAAQILPHDSYLINLGHPVSEALEKSRDAFLDEMQRCEQLGLTLLNFHPGSHLMQIAQEDCLARIAESINIALAQTEGVTAVIENTAGQGSNLGFEFEQLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLRTPEACEKTFAEFGQIVGFQYLRGMHLNDAKSAFGSRVDRHHSLGEGNIGHDAFRWIMQDARFDGIPLVLETINPDIWAEEIAWLKAQQSEKAVA
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: CHPF_STRCO
Sequence: MYNPKEHFSMSRIAKGLALTSVAAAAVAGTAGVAAADSGAQAAAAHSPGVLSGNVVQVPVHIPVNVCGNTIDVIGLLNPAFGNECEND
What is the function of this protein?
One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins (PubMed:12832396, PubMed:12832397, PubMed:15228525, PubMed:17462011).  Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation (PubMed:17462011).  Chaplins are also involved in cell attachment to a hydrophobic surface (PubMed:19682261).  Forms amyloid fibrils in vitro probably composed of stacked beta-sheets, at low extracellular concentrations individually restores the ability to form aerial hyphae to a chaplin-deficient strain (PubMed:21526199).  A small chaplin extract (ChpD, ChpE, ChpF, ChpG and ChpH) self-assembles into 2 different amyloids; small fibrils at the air-water interface form an amphipathic membrane that resembles spore-surface structures involved in aerial hyphae formation, and hydrophilic fibrils in solution that resemble the fibers that attach cells to a hydrophobic surface.  At the air-water interface the hydrophilic surface is in contact with water (probably equivalent to the peptidoglycan layer), while the hydrophobic face is exposed to the air, making the surface of the aerial hyphae hydrophobic (PubMed:24012833).  A small chaplin extract applied to a chaplin-deficient strain restores aerial hyphae formation (PubMed:12832396, PubMed:12832397).  The small chaplin extract forms an amyloid-like structure similar to that seen on the surface of cells without rodlets (rdlA-rdlB deletions), and is highly surface active, reducing surface tension from 72 to 26 mJ/m(2), which probably allows escape of hyphae from an aqueous environment into air (PubMed:12832396).  ChpF alone is less surface active at pH 3. 0 than at pH 10. 0, it reduces the surface tension of water from 72. 8 mN/m to 50 mN/m at pH 3. 0 or to 37 mN/m at pH 10. 0 (PubMed:28925983).  ChpF and ChpG are sufficient to restore the rodlet layer and hydrophobicity to a strain deleted for the other 6 chaplin genes (PubMed:15228525).
What are the official names of this protein?
Chaplin-F, Chaplin-G.
What is the protein family that this protein belongs to?
Belongs to the chaplin family. Short chaplin subfamily.
What are the subcellular locations of this protein?
Cell surface. Secreted, cell wall. Fimbrium. Note=Considerably more ChpF is seen in fimbrae than in aerial hyphae.
Protein: ATPA_AZOPC
Sequence: MSNIKSSEISDILKMQLKGIDSRIKFEEIGRVLQVSDGVARIFGLNNAETGELLQFDSGDMAVVMNLEEDNVGTVLLGETSKVQEGDRVKRTKRIVSIPMKNGMLGRVVNPFGSPLDGKGPILGKEIDMPLERKAPGVIYRCPVVEPLQTGIKSIDAMIPIGRGQRELIIGDRQVGKTTISIDTIINQKANYETGDPIYCIYVAIGQKASTVANIVNTLKEYGALNYTIIVVAAASDPAAMQFYAPFAGAAIGEFFRDTGRHALVVYDDLSKHAVAYREVSLVLRRPSGREAYPGDIFYLHSRLLERAAKIINNDSVAASMNDLPNNLRGQVKGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETGLFNAGIRPAVNVGISVSRVGGKAQIKAMKKVAGTLKIDQAQYRELEAFTKFGGDMDAVTRATLDKGRKNVELLIQSQYNPLPVEKEIAIIFIGIKGLLSDVPVERVREFETEFLDILEMKYRKDILDMLKQGVLDEKIEKKLNTIASIVANNFK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BRNP1_RAT
Sequence: MNWRFVELLYFLFVWGRISVQPSHQEPAGTDQHVSKEFDWLISDRGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLVRHPVPLMPEFQRSIRLLGRRPTTQQFIDTIIKKYGTHLLISATLGGEEALTMYMDKSRLDRKSGNATQSVEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGLLGCNSYDNLDSVSSVLLQSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYVCQNSQCRCQCAEEFPQCNCPITDIQIMEFTLANMAKAWTEAYKDLENSDEFKSFMKRLPSNHFLTIGSIHQHWGNDWDLQSRYKLLQSATEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQQWLARVQSLLYCNENGFWGTFLESQRSCVCHGSTTLCQRPIPCIIGGNNSCAMCSLANISLCGSCNKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISNEIRLDTFFDLRWRKRMSLTLKSNKNRMDFIHMVIGMSMRICQMRNSSLDPMFFVYVNPFSGSHSEGWNMPFGEFGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTRLPTLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQGGQFYSSSSVMLLMLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNHALDLYNTEILKQSDQMTAKLC
What is the function of this protein?
Inhibits cell proliferation by negative regulation of the G1/S transition.  Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway (By similarity).
What are the official names of this protein?
BMP/retinoic acid-inducible neural-specific protein 1, Deleted in bladder cancer protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the BRINP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEC_ACIET
Sequence: MSRLPQRRALVLLSGGQDSATCLAWALARYGHVETLGFDYGQRHRVELDCRQRLIDGVRALPWPGQLGPDHMLTVDVLAQLGGSAMTDDVAIAMQADGLPNTFVPGRNLLFFTLAAALAYRRGLDVLVGGMSETDYSGYPDCRDSTLKALQVALSLGVDRPLTLETPLMWRSKADTWALAQRLGGDALVELIRCESHTCYLGQRGDLHAWGHGCGGCPACELRAQGWEQWTAQRSLNGA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: CNBL5_ARATH
Sequence: MGCVCSKQLEGRRQEDISLLASQTFFSEAEVEVLHGLFIKLTSCLSNDNLLTKEKFQFILIKNTKKRSLSAERIFGLFDMRNDGAIDFGEFVHTLNIFHPNSSPRDKAIFAFRLYDTRETGFIEPEEVKEMIIDVLEESELMLSESIIDSIVSKTFEEADWKKDGIIDLEEWENFVATYPLTLKNMTIPFLKDIPRIFPTFLR
What is the function of this protein?
Acts as a calcium sensor.  CBL proteins interact with CIPK serine-threonine protein kinases.  Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.  May function as a positive regulator of salt or drought responses.
What are the official names of this protein?
Calcineurin B-like protein 5, SOS3-like calcium-binding protein 4.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Targeted to the cell membrane when interacting with CIPK24.
Protein: SND1_BOVIN
Sequence: MASSAQSGGSSGGPAVPTVQRGIVKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLARRAAVAQPDAKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKDTNGENIAESLVAEGLATRREGMRANNPEQNRLAECEEQAKASKKGMWSEGNGSHTIRDLKYTIENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDYYLVTVMLSGIKCPTFRREADGSETPEPFAAEAKFFTESRLLQRDVQIILESCHNQNILGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVAPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPRLEGENTQDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATDTVPAFSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHIDGANLSVLLVEHALSKVHFTAERSAYYKSLLSAEEAAKQKKEKVWAHYEEQPVEELMPVLEEKERSASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKFVDGEWYRARVEKVESPAKVHVFYIDYGNREILPSTRLGTLPPAFSTRVLPAQATEYAFAFIQVPQDEDARTDAVDSVVRDIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYGDFRADDADEFGYSR
What is the function of this protein?
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity).  As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity).  Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity).  Plays a role in PIM1 regulation of MYB activity (By similarity).  Functions as a transcriptional coactivator for STAT5 (By similarity).
What are the official names of this protein?
Staphylococcal nuclease domain-containing protein 1, 100 kDa coactivator, p100 co-activator.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Melanosome. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus.