PharMolix/UniProtQA huggingface dataset:
Protein: FABH_ACTP2
Sequence: MYSKILATGSYLPAQIRTNADLEKMVDTSDEWIFTRSGMKERRIAAADETVATMGAQAAKNALEIANIDHNEIDLIVVGTTTNSHAYPSAACQIQGMLDIQDAIAFDVAAACTGFVYALSVADQFIRSGKIKKALVIGSDLNSRALDETDRSTVVLFGDGAGAVILEASEEQGIISTHLHSSSDTEYMLALPAQKRGDEKSGFIQMQGNATFKLAVGQLSSVVEETLEANNLQKSDLDWLVPHQANIRIIAATAKKLEMDMSQVVLTVEKYGNNSAATVPVALDEAVRDGRIQRGQLLLLEAFGGGWTWGSALVRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_STRMU
Sequence: MLTRGEEKNMSKTIHFIGIKGSGMSALALLLHQMGYKVQGSDVDKYYFTQHGLEKAGIPILPFAESNITNDMEIIAGNAFRKDNNIEVAYALENGYHFKRYHEFLGEFMNQFTSLGVAGAHGKTSTTGLLAHVLKNITDTSYLIGDGTGRGLANSQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYFTGVDDVFAAFNDYAKQVKKGLFVYGEDPYLRKLTSSAPIYYYGFKDNDDFVAYDIMRSTNGSDFKVRHGQNELGSFHVPAFGRHNVLNATAVIANLYIAGVEMDLVRQHLKTFSGVKRRFSEKLINDVTIIDDFAHHPTEIIATLDAARQKYPSKEIVAIFQPHTFTRTIALLDEFAQALNEADSVYLAQIYGSAREVDHGDVKVEDLADKIVKPAKVITVDNVSPLLDHHNAVYVFMGAGDIQLYERSFEELLSNLTKNTR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_PYRAE
Sequence: MLSARVLKNTGFLRKQCPLCKSYFWTLRRDQEYCGDQPCVPYGFIGNPPTKISIDSLTELRERFLRFFERRGHARIKRYPVVARWRDDVYLVGASIYDFQPWVTSGAVPPPANPLVISQPSIRLTDVDKVGRSGRHLTGFEMMAHHAFNYPDKFIYWIDETAEYAYEFFTKELGIPPEEITFKESIWEGGGNAGECFEVLVRGLEVATLVFMHYEVKEGKYVELPLKIVDTGYGLERIYWLIRGTPTIYDAVFGPYLDKARRSLGFPEPPSELMGKASVYFGQMDPEVIGLEKAYDIIAEKIGVDPKWLREVFKPQEALYVLADHSRTVSWMIADGVIPSNSGAGYLARLLLRRILKNLKLVGVETPLVELFDMHLKELKADYPEVWEARNLILELVDIEERKYREILKSAPGVVKKAYEEARRRGRAGFDAEDLVSLYDSFGLPPEIVAETAKSLGVEVKIPDDFYSRLAARHAKREKQPEKTLVEMAKIADLPRTRELFYEDPYMKSFKAKVLRVIDGKYVVLDQTAFYAEGGGQPADIGILKHGGGAAKVVDVQRVGHVIVHVVEGEAPPEGSEVVGEIDWDRRYALMKMHTGTHVLIQSIRRVLGPHIWQAGAQKDIPASRIDVTHFKLPTAEEVAEIERLANSVVQANMPVHVKILPRNEAEAKYGFILYQGGVVPAREIRVVQIGPDEAPYDVQACGGTHLKSTGEIGLIKIQKVERIADGVVRFIFTTGLHALKYVQEIERQVAEAASLAGGNRDNLVDSVRRLLQRAEEAERKAQRYTELYAAEFVKNLKAEPVGKYRLAVVELEDEELAKKVAQIATGRDKELVLLVVGGGRVTVYTGGADVGPIVKALREVGFRGGGSRTFAQGVYSGDVKTLIDAVKRALA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLU7_CANGA
Sequence: MHNKKVTKDEKKNTKTKDVNEHIPNYIKNLPWYYQDIDKNSKNNSKEQDYLRHHRQRRDDKTIDIDNNDQAKIGTGIKDEFEVIVENKKTTIDGIIKRRKDEKDWDARKDRWYGYSGKEYEEVLKKWEKSREDLNNTTEESAYDTDEEIEMMKLGLTPKDLEQNIKGSSVRLREDKAAYLKDIYSSTTNYDPKSRLYKSDDLGSIDEHSNMFLRHLTGEGKELNDLNKFARENAKESGIRDELVDADKVNHVLVANPTKLEVLRKQKELDSLKLTEEQNRQEQRKLKRKAKLLKKKAKKPKGTPQSDSTKAQLMDMYG
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor SLU7.
What is the protein family that this protein belongs to?
Belongs to the SLU7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CALB1_RAT
Sequence: MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELLQARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQELDINNISTYKKNIMALSDGGKLYRTDLALILSAGDN
What is the function of this protein?
Buffers cytosolic calcium.  May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
What are the official names of this protein?
Calbindin, Calbindin D28, D-28K, Spot 35 protein, Vitamin D-dependent calcium-binding protein, avian-type.
What is the protein family that this protein belongs to?
Belongs to the calbindin family.
Protein: TRHBO_MYCTO
Sequence: MPKSFYDAVGGAKTFDAIVSRFYAQVAEDEVLRRVYPEDDLAGAEERLRMFLEQYWGGPRTYSEQRGHPRLRMRHAPFRISLIERDAWLRCMHTAVASIDSETLDDEHRRELLDYLEMAAHSLVNSPF
What is the function of this protein?
When expressed in E. coli and M. smegmatis, HbO increases oxygen uptake.  Membrane vesicles of E. coli carrying HbO show a respiration activity about twice that of membranes without HbO.  HbO seems to interact with a terminal oxidase.  Therefore, HbO could participate in oxygen/electron-transfer process, suggesting a function related to the facilitation of oxygen transfer during aerobic metabolism of M. tuberculosis (By similarity).
What are the official names of this protein?
Group 2 truncated hemoglobin GlbO, Hemoglobin-like protein HbO, Truncated hemoglobin, trHbO.
What is the protein family that this protein belongs to?
Belongs to the truncated hemoglobin family. Group II subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PSBU_PHATR
Sequence: MKLAVFAVLISTVAAFVAPNGVQRAATTELNAERREFLSAAAVAAGLAFPLTANAIRDYENVGYLGGSEIVDVNNANVRVYLKMPGLYPTLAGKIASNGPYNAVGDLYNIPGLSGKEKELLKKYESRFTAQKPQADYVIDRFNNGLYR
What is the function of this protein?
Stabilizes the structure of photosystem II oxygen-evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation.
What are the official names of this protein?
Photosystem II 12 kDa extrinsic protein, chloroplastic, PS II complex 12 kDa extrinsic protein, PSII-U.
What is the protein family that this protein belongs to?
Belongs to the PsbU family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with photosystem II at the lumenal side of the thylakoid membrane.
Protein: C71AP_ARATH
Sequence: MMMMIILLWSIIFMTILFLKKQLSGKKGKTPPSPPGLPLIGNLHQLGRHTHRSLCDLSRRYGPLMLLHLGRVPVLIVSSADMAQEILKTHDQAFANRPRSKLSQKLLYNNRDVASAPYGEYWRQMKSVCVIHLLSNKMVRSFRDVREEEITLMMAKIRKSSSLPFNVSKVLECLTNDVICRVALGRKYGGETDFKKLTDRLSELLGTFSIGSFVPWLAWVDWIRGWDAQLDKMGKDLDDFFEKVVQDHEDGDRRDGTDLIDALLRVKREKSPGFEIERVSIKAITLDVFVGGSDTSFTLLEWAMTELLRHPKSLNRLQEEVRTICKGKSRVSEDDIQGMKYLKAVIKEALRLHPPFPMMAPHESTEDVKLRDYHIPAGTQVMMNAWAIGREVATWGPDAEEFKPERHLDTSVDFRGQNFELLPFGAGRRICPAVSFAVVLNEVVLANLVHGFDWKLPEESKEDKTDVAESSGFSVHREFPLYAVASPYLT
What are the official names of this protein?
Cytochrome P450 71A25.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: OR35A_DROME
Sequence: MVRYVPRFADGQKVKLAWPLAVFRLNHIFWPLDPSTGKWGRYLDKVLAVAMSLVFMQHNDAELRYLRFEASNRNLDAFLTGMPTYLILVEAQFRSLHILLHFEKLQKFLEIFYANIYIDPRKEPEMFRKVDGKMIINRLVSAMYGAVISLYLIAPVFSIINQSKDFLYSMIFPFDSDPLYIFVPLLLTNVWVGIVIDTMMFGETNLLCELIVHLNGSYMLLKRDLQLAIEKILVARDRPHMAKQLKVLITKTLRKNVALNQFGQQLEAQYTVRVFIMFAFAAGLLCALSFKAYTNPMANYIYAIWFGAKTVELLSLGQIGSDLAFTTDSLSTMYYLTHWEQILQYSTNPSENLRLLKLINLAIEMNSKPFYVTGLKYFRVSLQAGLKILQASFSYFTFLTSMQRRQMSN
What is the function of this protein?
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates.  The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration.  Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.  Involved in the behavioral responses to esters.  Involved in the behavioral responses to butanol, pentanol, hexanol, octanol, propyl acetate, and butyl acetate.
What are the official names of this protein?
Odorant receptor 35a.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ABCB6_XENTR
Sequence: MVRLGSYCEHNGSISQAWLDSGLSPCFYFTLVPSVLLSFSFLLGALQSALYARHSTTMEPKYIPRSRLYRLQIVLSVVLILQSVIGLIWQAAGTDVVYGYMIVHGCLSVVAWGFSLWLLHLERTRALVREKSRGHGVVLLLFWALAFAAENLAFISWQSPNWWWLSRDTVPQKVQFGLWITRYVCTLFLFVLGIRAPGRPRKPYIVLINEDERDVETSQPLLRDPNQSTWQGFKKKLLLVMQYIWPRRNIPLQLLVALCMGLMGLERAINVFVPIYAKKIVDGLTEDSTWNILAVTVCIYVLLKFLQGGGAGTTGFLSNLRTFMWIRVQQFTNREVQIRLFAHLHSLSLRWHLGRKTGEVLRSVDRGTSSINSLLSYIVFSILPTIADIVIGIVYFTSSFNAWFGLIIFVCMTLYLTLTIIITEWRTKYRREMNTRDNEAKSRAVDSLLNFETVKYYNAEGYEVGRFNDSIMKYQVSEWKVNASLAMLNQTQNLIIGLGLLAGSLLCAYFVTENKFKVGDYVLFGTYIIQLYTPLNWFGTYYRMIQSSFIDMENMFELFNEDQEVKDAVNAPALMFRSGKIEFENVHFSYLDGKEILRDISFTVMPGQSIALVGPSGSGKSTIIRLLFRFYDVKGGTIKVDGQDISTVRQESLRSHIGVVPQDTVLFNDTIRNNIRYGRVSATDDEVEEAAAAADIHERILSFRDGYDTQTGERGLKLSGGEKQRVAIARTILKAPQIILLDEATSALDTETERNIQASLAKVCANRTTIVVAHRLSTVINSDQILVLKEGQIVERGRHEELLLKGGVYAGMWQKQQSGSESSSDSDSERKDRTSEKLQPPKATPRRGH
What is the function of this protein?
ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen.  May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress.  May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils.  In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (By similarity).  In addition may play a role in the transition metal homeostasis (By similarity).
What are the official names of this protein?
ATP-binding cassette sub-family B member 6, ABC-type heme transporter ABCB6.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Lysosome membrane. Late endosome membrane. Early endosome membrane. Secreted, extracellular exosome. Mitochondrion. Endosome, multivesicular body membrane. Melanosome membrane. Note=Present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation. Traffics from endoplasmic reticulum to Golgi during its glycans's maturation, therefrom is first targeted to the plasma membrane, and is rapidly internalized through endocytosis to be distributed to the limiting membrane of multivesicular bodies and lysosomes. Localized on the limiting membrane of early melanosomes of pigment cells (By similarity). Targeted to the endolysosomal compartment (By similarity).
Protein: PCP_STRS2
Sequence: MKIIVTGFDPFGGEPINPALETIKSLPKTIAGAEIILVEIPTVFDKAADVLEEKMAEHLPDAVLCIGQAGGRVDLTPERIAINQDDARIPDNEGQQPIDRTIREDGQPAYFSTLPIKAMVEAIHRIGLPASVSNTAGTFVCNHLMYQALYLAEKQFPKTKAGFLHIPFLPEQVVDKPGLASMSLNDIVRGVEVAIGAIVEYRDKEDIKKGGGSTH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRGA_STAA9
Sequence: MKQQKDASKPAHFFHQVIVIALVLFVSKIIESFMPIPMPASVIGLVLLFVLLCTGAVKLGEVEKVGTTLTNNIGLLFVPAGISVVNSLGVISQAPFLIIGLIIVSTILLLICTGYVTQIIMKVTSRSKGDKVTKKVKIEEAQAHD
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB.  The LrgAB and CidAB proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgA.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. LrgA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BHE40_SHEEP
Sequence: MERIPSAQPPPTCLPKAPGLEPGDLPGMDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGRNVEAGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKAMDFKEKPSSLAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTDTDSGYGGESEKSELRVEQPYFKSDHGRRFTMGERISAIKQESEEPPMKKSRMQLSDDEGPFTSTDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAAALSSFMNPDKISAPLLMPQRLPSPLPSHPAIDSSALLQALKQIPPLNLETKD
What is the function of this protein?
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes.  Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop).  Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2.  Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes.  Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2.  Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity.  May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (By similarity).  Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (By similarity).  Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (By similarity).
What are the official names of this protein?
Class E basic helix-loop-helix protein 40, bHLHe40, Class B basic helix-loop-helix protein 2, bHLHb2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus (By similarity).
Protein: RL5_COLP3
Sequence: MAKLHDLYKDTVVAELQKQFGYKSVMQVPRIEKITLNMGVGEAISDKKVLEHATNDLTAISGQKPITTVARKSVAGFKIREGYPIGTKVTLRGERMWEFLERLISISIPRIRDFRGLNPKSFDGRGNYSMGVREQIIFPEIEYDKIDKIRGLDITITTSAKDNEEGLALLSAFDFPFKKKV
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RS12_DESOH
Sequence: MPTINQLVRNGRKRATKKTTTPALKGAPQKRGVCVRVYTTTPKKPNSALRKVARVRLTTGIEVTAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDTLGVSDRKQGRSKYGTKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: NADE_BURA4
Sequence: MTSADYASRQRAIIAELNVAPHFDVDADIARRVDFLAQYLRSSGLRTYVLGISGGVDSSTAGRLAQLAVEQLRAGGYDARFIAMRLPNGVQNDEADAQRALAFVRADETFTVDVKPAADAMLASLVASGHAFETPAQQDFVHGNIKARERMIAQYAVAGARRGIVIGTDHAAESLMGFFTKFGDGGADVLPLAGLSKRRVRAVARALGGDELIVMKVPTADLEELRPLRPDEHAYGVTYDEIDDFLEGKTVSDTVYETVLRFYDGSRHKRALPYTLFDWPTA
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: RL34_PYRIL
Sequence: MPRPAYRSRSLRRVKVRTPGGRTVVHYEKRAKGVPKCPVTNLPLGGMNHKVYRFGISIRAPSRPYGGVFSHKVLARALRLAVRG
What are the official names of this protein?
50S ribosomal protein L34e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL34 family.
Protein: SIRG_LEPMC
Sequence: MTERPKDIPEDKLVLYVVKATPTSTANTVKPLIVMNELSIDHEIYVVPSPTRDEWFHQINPHKMVPAIESAETRDGKRLNIWESTSCLTYLTDAYDHEGLWKGSDLWERTQVNNWLTLHTAALGATGKYWLYFSAIHPEKIPAVIEKLANNIKVQYDILERRLSEKGQKYIALPDRPTIADVANLPFVTEELALKAGLRLGDWPNLQAWSEKMLARPSVQKALSQKFRPSVMIR
What is the function of this protein?
Glutathione S-transferase; part of the gene cluster that mediates the biosynthesis of sirodesmin PL, an epipolythiodioxopiperazine (ETP) characterized by a disulfide bridged cyclic dipeptide and that acts as a phytotoxin which is involved in the blackleg didease of canola (PubMed:15387811, PubMed:18272357, PubMed:19762440).  SirD catalyzes the O-prenylation of L-tyrosine (L-Tyr) in the presence of dimethylallyl diphosphate (DMAPP) to yield 4-O-dimethylallyl-L-Tyr, and therefore represents probably the first pathway-specific enzyme in the biosynthesis of sirodesmin PL (PubMed:19762440, PubMed:21038099, PubMed:24083562).  4-O-dimethylallyl-L-Tyr, then undergoes condensation with L-Ser in a reaction catalyzed by the non-ribosomal peptide synthase sirP to form the diketopiperazine (DKP) backbone (PubMed:18272357).  Further bishydroxylation of the DKP performed by the cytochrome P450 monooxygenase sirC leads to the production of the intermediate phomamide (PubMed:27390873).  This step is essential to form the reactive thiol group required for toxicity of sirodesmin PL (PubMed:27390873).  The next steps of sirodesmin biosynthesis are not well understood yet, but some predictions could be made from intermediate compounds identification (PubMed:18272357).  Phomamide is converted into phomalizarine via oxidation, probably by sirT (PubMed:18272357).  Further oxidation, methylation (by sirM or sirN) and reduction steps convert phomalizarine to deacetyl sirodesmin (PubMed:18272357).  Finally, acetyltransferase sirH probably acetylates deacetyl sirodesmin to produce sirodesmin PL (PubMed:18272357).
What are the official names of this protein?
Glutathione S-transferase sirG, Sirodesmin biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: BPT_XANOM
Sequence: MAIHADTHDDLRLFQTGEHACGYWSDRRARDLVLDPHDPRLGAIYPQALAWGFRRSGDLVYRPHCERCRACVPVRIAVDAFHPDRSQRRCLTRNQDLVVRVVAAERTDEQLALYRQYLKYRHPGGGMDEHGATEFDQFLIGGWSHGRFLEIREPAIAHLPGRLLAVAVTDVTEHALSAVYTFYAPEAAARSLGTFAILQQIQWAQRERRAHVYLGYWIEGHAKMNYKRRFSALEAYDGRHWCDLPAHPSGT
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSD_SERP5
Sequence: MKKGVLLNADVSAVVSRLGHTDQIVICDAGLPIPAATQRIDLALTQGVPTFLQVLGVVTQEMQVESAILAEEIVKQNPQLHRALLAQLTELGQHQGNTISVSYISHSAFKAQTEHSRAVIRSGECSPYANVILCAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAZY1_ARATH
Sequence: MKFWGWMHHKFRENSKEPLKDASTGNSYSILSAHPSLDSQEVYPTACAGSRYNTGFRKQVNLFQESSFAGPKQYTEEDFKDERNSDFFDGFLAIGTLGGETLLDEQPATPTFGMSFEDPAIDDADVTENDLKLISNELDKFLEAEAKEGHHQPSGRNSDTNTIASTIEAIEGVDDEEDNQPMKFPLQEYFFGSLIELPESKIAGKKDRASLGELFQITEVQDKQSENIYGKKKKQPNSAHKSAKHLVKKVLKKIHPSSRGSVSGKPEVDSTKKKFQKMVQVFHRKVHPEESIMETKIYSSVANPKSSKANSIDLTFEKVNHCHEASKRCIQYELRSSRSAKNGEHWIKTDEDYFVLEL
What is the function of this protein?
Involved in the regulation of shoot gravitropism (PubMed:23331961, PubMed:25028496).  Involved in the regulation of inflorescence branch angle (PubMed:23331961).  Functions redundantly with LAZY2, LAZY3 and LAZY4 to control plant architecture by coupling gravity sensing to the formation of auxin gradients (PubMed:28821594).  Involved redundantly with LAZY2 and LAZY4 in the regulation of both shoot and root gravitropism (PubMed:28765510).  Mediates gravity signaling in statocytes downstream of amyloplast displacement, leading to the generation of asymmetric auxin distribution in gravity-responding organs (PubMed:28765510).  Regulates the direction of polar auxin transport in response to gravity through the control of asymmetric PIN3 expression in the root cap columella (PubMed:28765510).  Regulation of auxin flow by the three proteins LAZY1, LAZY2 and LAZY4 in statocytes influences plant architecture by controlling the growth angle of lateral shoots and lateral roots (PubMed:28765510).
What are the official names of this protein?
Protein LAZY 1, AtLA1, AtLAZY1, Protein LAZY1-LIKE 1.
What is the protein family that this protein belongs to?
Belongs to the LAZY family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Nucleus.
Protein: SCX1_CENII
Sequence: KEGYLVNHSTGCKYECYKLGDNDYCLRECKQQYGKGAGGYCYAFGCWCTHLYEQAVVWPLPKKTCN
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Beta-toxin Cii1, Cii 1, Toxin 1.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.