PharMolix/UniProtQA huggingface dataset:
Protein: CYB_GALMO
Sequence: MTNIRKQHPLAKMINHSFIDLPAPSNISSWWNFGSLLGLCLMIQIITGLFLAMHYSSDTSTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLFTHIGRGLYYGSFTFLETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTGLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMIHLLFLHETGSNNPSGISSDSDKIPFHPYYTIKDLLGAILLLLSLFSLVLFSPDLLGDPDNYIPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVSSILILALIPYLHTAKQRSMMFRPLSQCLYWMLVADLFTLTWIGGQPVENPFITIGQTASIIYFLIVLILMPLTNLLENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RLMI_ALIF1
Sequence: MTVSIYLAKGRDKALRRRHPWIFSRGIDRIDGKAELGETVEIYANNGEWLARGAFSPQSQIRARVWTFDKNEAIDKDFFVRKLNQAQALRNVLAERDGLTGYRLIAAESDGLPGITIDRYQDYFVCQLLSAGAEATKELLVEALVECYPDCNIYERSDVSVRKKEGLKQRTGVLHGEEPPESVVIEENGVKISVDIVNGHKTGFYLDQRDSRERACKYVKNKSVLNCFSYTGGFGLYALKGGAKHVINADVSQLALDTAKYNAEINKFDLSKAEFLNADVFKLLREYRDNGTKFDVVIMDPPKFAESKNQLTGACRGYKDINMLAMQILNPGGTLLTYSCSGLMDAGLFQKIVADAALDAHRTVQFIERFEQAADHPLDSAYPEGFYLKGFACRVV
What is the function of this protein?
Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase I, 23S rRNA m5C1962 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RlmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGJ_BACCR
Sequence: MMIKVASITKLENGSIVTPKGFSAIGTVNGLKKEKKDLGAIVCDVPASCAAVYTTNQIQAAPLQVTKDSITAEGKLQAIIVNSGNANACTGMQGLQDAYEMRVLGAEHFGMKENYVAVASTGVIGVPLPMDIIRKGVATLIPTKEESEAYSFSEAILTTDLITKETCYEMIIDGKKVVIAGVAKGSGMIHPNMATMLSFITTDAHIEHNVLQTALSQITNHTFNQITVDGDTSTNDMVIVMASGLSETRPINMEHTDWETFVGALQKVCEDLAKKIAQDGEGATKLIEVNVLGAQTNEEAKKIAKQIVGSSLVKTAIHGEDPNWGRIISSIGQSEVAINPNTIDITLQSISVLKNSEPQTFSEEKMKERLQEDEIVINVYLHLGEETGSAWGCDLSYEYVKINACYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMA_I81A3
Sequence: MEAKLFVLFCTFTVLKADTICVGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCSLNGIAPLQLGKCNVAGWLLGNPECDLLLTANSWSYIIETSNSENGTCYPGEFIDYEELREQLSSVSSFEKFEIFPKASSWPNHETTKGVTAACSYSGASSFYRNLLWITKKGTSYPKLSKSYTNNKGKEVLVLWGVHHPPTTSEQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRGQAGRMNYYWTLLDQGDTITFEATGNLIAPWYAFALNKGSDSGIITSDAPVHNCDTRCQTPHGALNSSLPFQNVHPITIGECPKYVKSTKLRMATGLRNVPSIQSRGLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMNTQFTAVGKEFNNLERRIEKLNKKVDDGFLDVWTYNAELLVLLENERTLDFHDSNVRNLYEKVKSQLRNNAKELGNGCFEFYHKCDDECMESVKNGTYDYPKYSEESKLNREEIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: RIR1_MYCTU
Sequence: MPPTVIAEPVASGAHASYSGGPGETDYHALNAMLNLYDADGKIQFDKDREAAHQYFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKTLLDRAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTALAELLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLLRVEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKRNDDMYLFSPYDVERVYGVPFADISVTEKYYEMVDDARIRKTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSLFNEDLSYAKVGKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLARERIFYGSDEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKYASGEFFDKYTDQIWEPKTQKVRQLFADAGIRIPTQDDWRRLKESVQAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLEYYEDAYEIGYEKIIDTYAAATQHVDQGLSLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCML
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.  When coexpressed in E. coli with nrdF2 the 2 proteins complement a temperature-sensitive E. coli mutant, however coexpression with nrdF1 does not complement.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase subunit alpha, Ribonucleotide reductase R1 subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: KATG_MYCSM
Sequence: MPEDRPIEDSPPIGEAQTDAPAGGCPAGFGRIKPPVAGGSNXDWWPNQLNMKILQKNPDVINPLDEDFDYRSAVQNLDVDALRADIVEVMHTSQDWWPADFGHYGPLFIRMAWHAAGTYRVSDGRGGAGAGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKNLSWADLIVYAGNVALEDMGFRTAGFAFGREDRWEPEEDVYWGPEQEWLDRTKRYTGERDLENPLAAVQMGLIYVNPEGPNGNPDPQASAIDIRETFGRMAMNDVETAALIVGGHTFGKTHGNGDASLVGPEPEAAPLEEVGLGWRNPQGTGVGKDAITSGLEVTWTHTPTKWDNSFLEILYGNEWELTKSPAGANQWKPKDNGWANSVPLAHEDGKTHPSMLTSDLALRVDPIYEQITRRWLDHPEELAEEFAKAWFKLLHRDMGPVTRYLGPEVPKDTWLWQDNIPAGNDLSDDEVAKLKELIADSGLTVSQLVSTAWKAASTFRSSDLRGGANGGRIRLQPQLGWEANEPDELAQVVRKYEEIQKASGINVSFADLVVLGGNVGVEKAAKAAGFDVTVPFTPGRGDATQEETDVDSFAYLEPKADGFRNYLGKGSDLPAEFKLIDRANLLGLSAPEMTTLVGGLRVLDVNHGGTKHGVLTDKPGALTTDFFVNLLDMSTAWKPSPADDGTYIGTDRATGSPKWTGTRVDLVFASNSQLRALAEVYAEDDSKEKFVKDFVAAWTKVMDADRFDVA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.  May play a role in the intracellular survival of mycobacteria (By similarity).
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: NUOI2_CERS1
Sequence: MKGILDSILRVGRMIFAPTKTVQYPEEKLPLAPRTRGRIVLTRDPDGQERCVACNLCAAACPVDCIDVVKAETPDGRWYPESFRINFARCIFCGYCEEACPTSAIQLTPDVELADYRRGFLQYEKEDLLISGEGKHPGYRYWDVAGKTIAGKAQDPVDPKDLCP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I 2, NADH dehydrogenase I subunit I 2, NDH-1 subunit I 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DHAPP_DROME
Sequence: MDAKEFREFGKAAIDYIADYLENIRDDDVLPNVEPGYLLDLLPTEMPEEPEAWKDVLGDISRVIKPGLTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFSWICSPACTELEVVVMDWLAKFLKLPAHFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRGRLVAYSSDQSNSCIEKAGVLAAMPIRLLPAGEDFVLRGDTLRGAIEEDVAAGRIPVICVATLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHKFMLVNFDCSAMWLRDANKVVDSFNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRALKVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRFELVAPRALGLVCFRPKGDNEITTQLLQRLMDRKKIYMVKAEHAGRQFLRFVVCGMDTKASDIDFAWQEIESQLTDLQAEQSLVARKSGNVGDLAQHFQIHLSTENATHEKSQ
What is the function of this protein?
Catalyzes the decarboxylation-oxidative deamination of L-3,4-dihydroxyphenylalanine (L-DOPA) to 3,4-dihydroxylphenylacetaldehyde (DHPAA) (PubMed:21283636).  Involved in cuticle development (Probable).  Probably responsible for the protein cross-linking during the development of flexible cuticles (PubMed:21283636).
What are the official names of this protein?
3,4-dihydroxyphenylacetaldehyde synthase, DHPAA synthase, DOPAL synthase, Alpha-methyldopa resistant protein, AMD-r protein.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: NDK_BORPA
Sequence: MSIERTLSIIKPDAVAKNVVGQIVARFEQAGLKVIAARMQQLSRTDAERFYAVHKERPFFKDLVDFMVSGPVFVQVLEGESAIQKNRDLMGATDPKKAAPGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPEINIHSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IOD1_FUNHE
Sequence: MFLQKLLVYLTAACMFCYILVLSATLNVLKVLSPNLARKLILKMGEKVTMTQNPKFSYEDWGLTYGSLAFIKVASQTMWLSLGQEAFVGEDAPDSPVVTVDGERTSICNYLKGNRPLVLSFGSCTUPPFMFKLGEFKQLVRDFVDVADFLVVYVAEAHSTDGWSFGNNFDIRQHRSLEDRLSAARILVQNDPLCPVVVDEMSNVSAIKYAAQPERLYVLQAGKVLYKGAMGPWGYNPQEVRSVLQKMR
What is the function of this protein?
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).
What are the official names of this protein?
Type I iodothyronine deiodinase, 5DI, DIOI, Type 1 DI, Type-I 5'-deiodinase.
What is the protein family that this protein belongs to?
Belongs to the iodothyronine deiodinase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: YBGC_ECOL6
Sequence: MNTTLFRWPVRVYYEDTDAGGVVYHASYVAFYERARTEMLRHHHFSQQALMAERVAFVVRKMTVEYYAPARLDDMLEIQTEITSMRGTSLVFTQRIVNAENTLLNEAEVLVVCVDPLKMKPRALPKSIVAEFKQ
What is the function of this protein?
Thioesterase that appears to be involved in phospholipid metabolism.  Some specific acyl-ACPs could be physiological substrates.  Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro, catalyzing the hydrolysis of the thioester bond (By similarity).
What are the official names of this protein?
Acyl-CoA thioester hydrolase YbgC, Acyl-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SYY_PYRAB
Sequence: MDIEERINLVLKKPTEEVLTVENLRHLFEVGAPLQHYIGFEISGYIHLGTGLMAGAKIADFQKAGIKTRIFLADWHSWINDKLGGDLEVIQEVALKYFKVGMEKSIEVMGGDPKKVEFVLASEILENGDYWQTVIDISKNVTLSRVMRSITIMGRQMGESIDFAKLIYPMMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLKYHPIVHNGEKLKPVAVHHHLLLGLQEPPVWPITSEEQFKEIKAQMKMSKSKPYSAVFIHDSPEEIKQKLRKAFCPAREVNYNPVLDWAEHIIFREEPTEFTIHRPAKFGGDVTYTTFEELKKDFAEGKLHPLDLKNAVAEYLIELLKPIREYFERHPEPLELMRSVKITR
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADC_MYCTU
Sequence: MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPASATTTASLVTREAGVVAGLDVALLTLNEVLGTNGYRVLDRVEDGARVPPGEALMTLEAQTRGLLTAERTMLNLVGHLSGIATATAAWVDAVRGTKAKIRDTRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAGSVVDALRAVRNAAPDLPCEVEVDSLEQLDAVLPEKPELILLDNFAVWQTQTAVQRRDSRAPTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDIGLDM
What is the function of this protein?
Involved in the catabolism of quinolinic acid (QA).
What are the official names of this protein?
Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NadC/ModD family.
Protein: ADRF_PENRO
Sequence: MSLLQDIVVIITGSASGIGLATATAALSQGARILGVDVSSAPVSLNEHPNYKFMQGDLTHETTPRQVVETCIKEFGGRIDGLLNIAGIMDQNSSVDSLSDYMWERCIAVNLTAPVKLMREVIPIMRQQQSGSIVNVGSKAATSGASSGVAYTASKHGLMGATKNVAWRYKQEGIRCNAVCPGGVPTGIVQASDPSTWDKDALGTMSLIHQAHAADRQKGLGVEAEDIADCLLFLISSQSKRINGAIIPIDNAWSVI
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of andrastins, meroterpenoid compounds that exhibit inhibitory activity against ras farnesyltransferase, suggesting that they could be promising leads for antitumor agents (PubMed:28529508).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase adrD via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (By similarity).  DMAO is then converted to farnesyl-DMAO by the prenyltransferase adrG (By similarity).  The methyltransferase adrK catalyzes the methylation of the carboxyl group of farnesyl-DMAO to farnesyl-DMAO methyl ester which is further converted to epoxyfarnesyl-DMAO methyl ester by the FAD-dependent monooxygenase adrH (By similarity).  The terpene cyclase adrI then catalyzes the carbon skeletal rearrangement to generate the andrastin E, the first compound in the pathway having the andrastin scaffold, with the tetracyclic ring system (By similarity).  The post-cyclization tailoring enzymes adrF, adrE, adrJ, and adrA, are involved in the conversion of andrastin E into andrastin A.  The short chain dehydrogenase adrF is responsible for the oxidation of the C-3 a hydroxyl group of andrastin E to yield the corresponding ketone, andrastin D.  The ketoreductase adrE stereoselectively reduces the carbonyl moiety to reverse the stereochemistry of the C-3 position to yield andrastin F.  The acetyltransferase adrJ is the acetyltransferase that attaches the acetyl group to the C-3 hydroxyl group of andrastin F to yield andrastin C.  Finally, the cytochrome P450 monooxygenase adrA catalyzes two sequential oxidation reactions of the C-23 methyl group, to generate the corresponding alcohol andrastin B, and aldehyde andrastin A (By similarity).
What are the official names of this protein?
Short chain dehydrogenase adrF, Andrastin A biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: NIFA_AZOC5
Sequence: MPMTDAFQVRVPRVSSSTAGDIAASSITTRGALPRPGGMPVSMSRGTSPEVALIGVYEISKILTAPRRLEVTLANVVNVLSSMLQMRHGMICILDSEGDPDMVATTGWTPEMAGQIRAHVPQKAIDQIVATQMPLVVQDVTADPLFAGHEDLFGPPEEATVSFIGVPIKADHHVMGTLSIDRIWDGTARFRFDEDVRFLTMVANLVGQTVRLHKLVASDRDRLIAQTHRLEKALREEKSGAEPEVAEAANGSAMGIVGDSPLVKRLIATAQVVARSNSTVLLRGESGTGKELFARAIHELSPRKGKPFVKVNCAALPESVLESELFGHEKGAFTGALNMRQGRFELAHGGTLFLDEIGEITPAFQAKLLRVLQEGEFERVGGNRTLKVDVRLVCATNKNLEEAVSKGEFRADLYYRIHVVPLILPPLRERPGDIPKLAKNFLDRFNKENKLHMMLSAPAIDVLRRCYFPGNVRELENCIRRTATLAHDAVITPHDFACDSGQCLSAMLWKGSAPKPVMPHVPPAPTPLTPLSPAPLATAAPAAASPAPAADSLPVTCPGTEACPAVPPRQSEKEQLLQAMERSGWVQAKAARLLNLTPRQVGYALRKYDIDIKRF
What is the function of this protein?
Required for activation of most nif operons, which are directly involved in nitrogen fixation.
What are the official names of this protein?
Nif-specific regulatory protein.
Protein: YQGF_CLOBB
Sequence: MRILGLDLGKKTIGVAVSDPLGFTAQGITTIRRANKEKDMEELRKICDEYKVETIVIGLPKNMNGTIGPSGEIAMEMGKLVEEALNIKVEFWDERLTTVAAHKAMLEADLSRSKRKKIVDKVASTYILQGYLDRISK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORSD_EMENI
Sequence: MPPVRFGPRKILEYDGRYGVLICHECRYAIQKSALQSHLLRHKIYRADRQQLVAMINELDLLEPDDVLLPPPESPPIDGLPVIAGYRCTAPGCANLCASLKRMKGHWRESHGIADASLARPAKLQTFFRGTKIRYFEVTPTTEDEDDEENESENDEEEGDVDLEEQEDDNGGRQSTTVTTSPGPSAPSVNVDLETLSYFHHFMSATSLTLPCPQDMQSGAQYWKEKAVPQALQQRWLMCGLLALAACHLAAFPDNAAAGQQHRKRAAEFSLEFRTGWRELADTSGEGLREVATEIECLLRCAHWALAESPCDQRIMPEPGVPEHLQSIISTIQSTVPAAAPHEAETSAYATRILRWNTSEAGNSVLAEIRNRLHDLPARMADTFGRPENIQDVLVLLSALAAMGECCDTSFASEEVGPAWWGMATWWTRVPLRFKELVARHYPASLVVVAHWAALMVNRTERCGCWLVKGLAMTILLRIAERLPEDDDGNVQRLVALTIAA
What is the function of this protein?
Part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B (PubMed:19666480, PubMed:20174687).  The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:19666480, PubMed:20174687).  Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B (PubMed:20174687).  The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B (PubMed:20174687).
What are the official names of this protein?
Orsellinic acid/F9775 biosynthesis cluster protein D.
Protein: PTXBC_STAEQ
Sequence: MSKEERLAKDITHALGGSQNISNIIHCMTRVRIKVHNDAKVNYDELKSINGVLGVVEDERIQVVVGPGIVNKVAKLMADQSGATLAEETTENQSYKSQAEKRAYEHKKQFQSQRKQSKWNKVLKSIANIFIPLIPAFIGAGLIGGIAAILSNLLTAGSISGQWIQQIVTVLNVIKDGMLFYLAIFTGINSAKVFGATPGLGGVIGGTTLLTGITDENPIKNIFTGEHLAAGQGGIIGVIFAVWLLSMVEKRLHKIIPNSIDIIVTPTITLLLIGLLTIFIIMPLAGFVSDGLVYVINWIIGVGGIFSGFIIGAFFLPLVMLGLHHIFTPIHIELINQTGSTYLLPIAAMAGAGQVGAAIALWVRCGKNKELRNTLKGALPVGFLGIGEPLIYGVTLPLGRPFFTACIGGGVGGAVIGGIGHIGATAVGPSGISLLPLIANNMYLGYIVGLLAAYAGGFIFTYFFGTTKEMRNPE
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in the uptake and phosphorylation of MurNAc-GlcNAc, the principle peptidoglycan turnover product of S. aureus, yielding cytoplasmic MurNAc 6P-GlcNAc.
What are the official names of this protein?
PTS system MurNAc-GlcNAc-specific EIIBC component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KEX1_SCHJY
Sequence: MSLSFLLRVAGLFFLQFNSAQAKSQVHEQWHVSSIPNVPAGYTGSLHSGYLNLTDKLEGDLFFTLYGSENEVHQNRTIIWLNGGPGCSSEDGSMLELGPLRLTNDSLVYYNAASWVRLGNVLFVDQPMGTGFSFADTRDAILNDNEKMSNDFAYFLQEFVKAFPEYATDTWYIAGESFAGQYIPAIAKKVIDSDIVNLSGIAIGNGWIEPASHYLTYLDYLVERGLLERGSALFEALTAVQAKCLMSLEQSASGMLEDENSCDKYLFDILFSVSDKSGEFCFNMYDVTLTSPYPSCGMEWPLELPALTDFLSSPDVMKALHVASDKVSRWEECSSLVSNFYADTNVFRTRFTIAELLEEIPVMLFYGENDFLCNYVSGEFLISNLEWSGKRGFENASNADWYPRYSEANTLEYGQYAAAAGIIHSERNLTYATIRNSSHMVPYDHPYEMLALVSAFFDNDFSQILMLPDPVTIVPNHSFLSIFLWVMAGILAFSAIGAICYYSYRHIRSRYDSYTPIQEESA
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase kex1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: CTAA_PARL1
Sequence: MNILPRINAIEKTDANHHAIAWWLIGVAALVFIMVVVGGLTRLTESGLSITEWKPVTGALPPMTEEHWQEEFDLYRQIPQYQLVNKGMSLDEFKTIYWWEWSHRFLGRLIGLAFFVPFVFFVVTRRVERALVPRLIFLFVLGGMQGVLGWWMVMSGLTDRTEVSQYRLAAHLGLATLIFGALIWTALDLLNGKSTRLLTGLAKAAAAILALIFLQTILGAFVAGIRAGLIYNTWPLMAGAFIPDGLFAMTPVWHNFFESHLTVQFQHRMTAYLLLLCVVWHWWAARKTAAAPSAGWLAVATFAQACIGIWTVLWVVPIPLGAAHQAGAMVVFGVAVWHVHRLAK
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.