PharMolix/UniProtQA huggingface dataset:
Protein: MDTD_YERPY
Sequence: MVTQATSVRWQLWIVAFGFFMQTLDTTIVNTALPSIAASLGENPLRMQSVIVSYVLTVAVMLPASGWLADRIGVKWVFFSAIILFTFGSLMCAQSATLNELILSRVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMAFVTLPGQIGPLVGPALGGFLVEFASWHWIFLINLPVGVIGALATLLLMPNHKMSTRRFDISGFIMLAIGMATLTLALDGHTGLGLSPLAIAGLILCGVIALGSYWWHALGNRFALFSLHLFKNKIYTLGLVGSMSARIGSGMLPFMTPIFLQIGLGFSPFHAGLMMIPMIIGSMGMKRIIVQVVNRFGYRRVLVNATLLLAVVSLSLPLVAIMGWTLLMPVVLFFQGMLNALRFSTMNTLTLKTLPDRLASSGNSLLSMAMQLSMSIGVSTAGILLGTFAHHQVATNTPATHSAFLYSYLCMAIIIALPALIFNRVPPDTGANRHLAR
What are the official names of this protein?
Putative multidrug resistance protein MdtD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS8_KARMG
Sequence: MITDPIADCLTRIRNGYLSNILIIEIPYSKIKKNIIKILYNQGFISSYKIEKINNYKLLIKVALKYNKYTGTSVIKCIKRISKPSLRKYCNYTNIPRVLNGLGIAIISTSKGLMTDKIARKKKIGGEIICYIY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: LAC_CHICK
Sequence: QPKVAPTITLFPPSKEELNEATKATLVCLINDFYPSPVTVDWVIDGSTRSGETTAPQRQSNSQYMASSYLSLSASDWSSHETYTCRVTHNGTSITKTLKRSEC
What are the official names of this protein?
Ig lambda chain C region.
Protein: ACNA_STAAR
Sequence: MAANFKEQSKKHFDLNGQSYTYYDLKAVEEQGITKVSKLPYSIRVLLESLLRQEDDFVITDDHIKALSQFGKDGNEGEVPFKPSRVILQDFTGVPAVVDLASLRKAMDDVGGDITKINPEVPVDLVIDHSVQVDSYANPEALERNMKLEFERNYERYQFLNWATKAFDNYNAVPPATGIVHQVNLEYLASVVHVRDVDGEKTAFPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPIPEVIGVRLVNSLPQGATATDLALRVTQELRKKGVVGKFVEFFGPGVQHLPLADRATIANMAPEYGATCGFFPVDDESLKYMKLTGRSDEHIALVKEYLKQNHMFFDVEKEDPNYTDVIELDLSTVEASLSGPKRPQDLIFLSDMKSSFENSVTAPAGNQGHGLDKSEFDKKAEINFKDGSKATMKTGDIAIAAITSCTNTSNPYVMLGAGLVAKKAVEKGLKVPEYVKTSLAPGSKVVTGYLRGAGLQPYLDDLGFNLVGYGCTTCIGNSGPLLPEIEKAIADEDLLVTSVLSGNRNFEGRIHPLVKANYLASPQLVVAYALAGSVDIDLQNEPIGKGNDGEDVYLKDIWPSIKEVSDTVDSVVTPELFIEEYNNVYNNNELWNEIDVTDQPLYDFDPNSTYIQNPSFFQGLSKEPGTIVPLNGLRVMGKFGDSVTTDHISPAGAIGKDTPAGKYLQDHQVPIREFNSYGSRRGNHEVMVRGTFANIRIKNQLAPGTEGGFTTYWPTNEVMPIFDAAMKYKEDGTGLVVLAGNDYGMGSSRDWAAKGTNLLGVKTVIAQSYERIHRSNLVMMGVLPLEFKKGESADSLGLDGTEEISVNIDENVQPHDYVKVTAKKQDGDLVEFDAMVRFDSLVEMDYYRHGGILQMVLRNKLAQ
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate.  Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate.  The apo form of AcnA functions as a RNA-binding regulatory protein.
What are the official names of this protein?
Aconitate hydratase A, ACN, Aconitase, (2R,3S)-2-methylisocitrate dehydratase, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase, Iron-responsive protein-like, IRP-like, Probable 2-methyl-cis-aconitate hydratase, RNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: SLYX_SALTY
Sequence: MQDITMEARLAELESRLAFQEITIEELNLTVTAHEMEMAKLRDHLRLLTEKLKASQPSNIASQAEETPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: RSME_ECOL6
Sequence: MRIPRIYHPEPLTSHSHIALCEDAANHIGRVLRMGPGQALQLFDGSNQVFDAEITSASKKSVEVKVLEGQIDDRESPLHIHLGQVMSRGEKMEFTIQKSIELGVSLITPLFSERCGVKLDSERLNKKLQQWQKIAIAACEQCGRNRVPEIRPAMDLEAWCAEQDEGLKLNLHPRASNSINTLPLPVERVRLLIGPEGGLSADEIAMTARYQFTDILLGPRVLRTETTALTAITALQVRFGDLG
What is the function of this protein?
Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA.  Acts on the fully assembled 30S ribosomal subunit (By similarity).
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase E, 16S rRNA m3U1498 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RsmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA_RHOJR
Sequence: MTMPYYASAEQIMRDRSELARKGIARGRSVVVLTFRDGVLFVAENPSTALHKVSELYDRLGFAAVGKYNEFENLRRAGIVHADMRGYSYDRRDVTGRSLANAYAQTLGTIFTEQPKPYEVEICVAEVGRVGSPKAPQLYRITYDGSIVDEQHFVVMGGTTEPIATAMRESYRADLDLEAAVGIAVNALRQGGAGEGEKRNVDVASLEVAVLDQSRPRRAFRRITGPALEQLIPAEPAPASEPAPESKPDTETKPADPQD
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit alpha, 20S proteasome alpha subunit, Proteasome core protein PrcA.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGOD_CROS8
Sequence: MKITKLTTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHELGEYLIGQDPARINDLWQVMYRGGFYRGGPILMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWVGGDRPAEVIAGIKTLRQIGFDTFKLNGCEELGIIDDSRKVDAAVNTVAQIREEFGSDIEFGLDFHGRVSAPMAKILIKELEPYRPLFIEEPVLAEQAEYYPRLAAQTHIPIAAGERMFSRFEFKRVLEAGGLAILQPDLSHAGGITECAKIAAMAEAYDVGLAPHCPLGPIALAACLHVDFISRNAVFQEQSMGIHYNQGAELLDFVKNKDDFKMEGGYFQPLMKPGLGVEIDEEQVVARSQGCADWRNPLWRHADGSVAEW
What is the function of this protein?
Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
What are the official names of this protein?
D-galactonate dehydratase, GalD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Protein: EIF3C_CANAL
Sequence: MSRFFVSGYTSDSSSEEEDLLSTSEEELLSSSDEGEDNESDSSFFGEDDDESEESSSDDEDGRPSGPAYFLKKSFLKGAGGDDSDSDSDDEGRKVVKSAKDKLLDDMKSSIEIINSNKYNNNWSIVLGEFDKFGRFLIRCNQTNLGTPKFYIKLLTSLDNSITETSNNERDDKTLKADEARAFNTLRQRIKKQIREFQVYYDLYKENPEEFDENEDEPLESVQAGLNDNVKNEADNSNVGALASNRVLSPIFHTLKTISESRGKKNIDKLEQIATLEKLLEANVSKSSPFELISIYQMLLSVRFDASSNQAFMPLEQWQKNEQDLGKLLDLLEANVDTYQVSELGSTTDDIDIEPVANAQGVKVIFGSITSSIDRLDDELTKSLQHTDPHSTEYVERLKDESTIYNLIVRGQAYVESITPEDVKYKSEQLARIVLRRLEHIYYKPKQLIKANEEEAWRNIEYNSSIVSKGSSVDEVIDQLTEFLQKQQKNKTYGKHAILFSIYYYAVNSQYEKAKELFLRSQFYSNINSAESSLQVQYNRALVQLGLSAFRAGSIEESHKILNEIVNSQRSKELLGQGFNSKFPNQATVLERQKLLPFHQHINLELLECVFMTCSLLIEIPTLAAIANNHKDSKRKNASLKSFKSKLDFHDRQFFTGPPESIKDHIVHASIALQKGDWLKSYNLLSSIKIWKLFPDNDKLLAMMKNQLQIEGLRTYIFTYKSVFKKLSIEKLQQIFQLSKDEVVSILEKMITTGNVSGGEIIDNKFISFTSTTEPQRSKLQELAIVLNEKIQLLTEKNEKTQSNGYGKKQQNKDQQNQQQQNQNQNQQQQQNQQQQQQQQSSQQQSNNILSEESANKFRYANVNSNNDEFQATA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_PERMH
Sequence: MRVLRSPAKVNLGLWVTGKRADGYHDIVTVFHTVDFHDRIFIKRSHSLKIKTSSPLIPEGEENIVYKALKRFEEWTGVSPEVEVFIEKNIPAGAGLGGGSSNAAVVLKEVNSMYGEILSEKELSELASTIGADVPFFLKGGLAVAEGIGDKLRFLDKKIEREIFIIYPAVHVSTKEIYSKVTPDILTKKEDLHIIDSLLDDFEYFLENIENTLGEIALESYPQMREVYNTLEYLGYKPFVSGSGSSIFAFGKPEAEIEKICQVKGWKLIKTVLR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: COAX_IDILO
Sequence: MLLIDAGNTRSKFAWWDADTDKIEILGAIPHQSWLNDLSQPLKDLLLEVVSSRQLEREQQAIGCSVAAVQVMDTLNSSLAELGIKVFWQKTRAQQAGVTNGYTKEPERLGSDRWMALLGCHEQVKQNALIVDAGTALTIDWLMADGRHLGGWIVPGRQLMLNALGQGTANLKGITVNDIERDGLAAGLDTFDGITQGAEAALTGAIAQAIQLSGRYFSDQPFDVVVTGGDGEHLMRTLSVEFCRYDDLLFKGLRLCADNLNS
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXC_CAMJ8
Sequence: MKQLTLAKTVKGVGIGLHKGEPIEITLEPLEANSGIVFFRSDLNASYKASPENVINTQMATVLGDDRGFISTIEHLMSAINAYGIDNVRIVLNANEAPVMDGSSISFCMMLDEAGVKELDAPKKIMVIKKPVEVRDGNKFVRLTPTKEPRINYTIKFDNAVIGEQSYNFEFSKKNYIENIARARTFGFLKDVQALRSMNLALGGSLENTIVVDENRILNPEGLRFKDEFVRHKILDAIGDLTLLGYRVFGDYISYAGSHHLNHLLTKEVLKDKDAYEIVSLEKTTQKAYEKVFA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: RECO_STRMU
Sequence: MQTKETRGLVLYNRPFREDDKLVKIFTETSGKHMFFVRHATNSKLSSVIQPLILANFILKINNHGLSYIEDYKGVSLFKEINADIYKLAYATYLVSLADAAISDAVYDAPLFAFLIKTLELMDEGLDYEILTNIFEIQILDRFGVQLNFHDCVFCHRVGLAFDFSHRYSGLLCPEHYEKDLYRSHLDPNVPYLLNQFQTLHFDSLKTISVKPDMKQKLRKFIDEVYEDYIGLRLKSKKFIDDLDHWGQVMK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: OOSP3_HUMAN
Sequence: MKDFVRLQSSFLLCTILTLSEQESVSVGCTSSMFWVVAEPTLLGQDHILHSDEASLGTGCPVTNVTAKGYEFNYPATQCGIQKEVFSYVTVFYSALHCNIMHKGVTGKIPLMCIVYGSSLDTTSSTIHNNLTEFQNDPPATNSYSPWNLTNASLFGLTRIPYFQNSSVEASHQSLLLNMSHPLVHESANVAIF
What are the official names of this protein?
Oocyte-secreted protein 3.
What is the protein family that this protein belongs to?
Belongs to the PLAC1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DPB3_YARLI
Sequence: MSEKPREIKTRFPVARIKKLMQSDDDIGKVAQATPTAVAKALELFMISLIEETCNQARMRNSKRVSPSHLKQAVLETEQFDFLQDIVSKHPDAVAPATGEEEQPKRRGRKPAQE
What is the function of this protein?
As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.
What are the official names of this protein?
DNA polymerase epsilon subunit C, DNA polymerase II subunit C.
What are the subcellular locations of this protein?
Nucleus.
Protein: HUS1B_MOUSE
Sequence: MRFRARITSKRFIELFIQVSSTVAKLAKVCVLRVCPDRLYFCPMGLLGEAQLWGEMRRDVFHHFCMEGASQEFNEICLELMSEHLARAVKNAGNASSLKLQLTNKQRPCLTLVVELASCPGHTRAVVHDLPVRVLPRRRWKDCTEPHVRGSDVSVYLPALKTLKNMVERMANVGSHVLVEANLNGRMNLTVETDRVTIKSYFKNLGNPPNAVLCMSQGRDPETMVQVRVDNRKLLQCFDGHQINPTMALCNILSNTLLHLVLVHEDISLQYFIPAS
What are the official names of this protein?
Checkpoint protein HUS1B, mHUS1B.
What is the protein family that this protein belongs to?
Belongs to the HUS1 family.
Protein: RDRP_IBDVU
Sequence: MSDVFNSPQARSKISAAFGIKPTAGQDVEELLIPKVWVPPEDPLASPSRLAKFLRENGYKILQPRSLPENEEYETDQILPDLAWMRQIEGPVLKPTLSLPIGDQEYFPKYYPTHRPSKEKPNAYPPDIALLKQMIYLFLQVPEATDNLKDEVTLLTQNIRDKAYGSGTYMGQATRLVAMKEVATGRNPNKDPLKLGYTFESIAQLLDITLPVGPPGEDDKPWVPLTRVPSRMLVLTGDVDGEFEVEDYLPKINLKSSSGLPYVGRTKGETIGEMIAISNQFLRELSALLKQGAGTKGSNKKKLLSMLSDYWYLSCGLLFPKAERYDKSTCCTKTRNKWSAQSSTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRIVEWIMAPDEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYYILTRGWSDNGDPMFNQTWATFAMNIAPALVVDSSCLIMNLQIKTYGQGSGNAATFINNHLLSTLVLDQWNLMKQPSPDSEEFKSIEDKLGINFKIERSIDDIRGKLRQLVPLAQPGYLSGGVEPEQPSPTVELDLLGWSATYSKDLGIYVPVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYPLLNKACKNNASAARRHLEAKGFPLDEFLAEWSELSEFGEAFEGFNIKLTVTPESLAELNRPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLVLLATARSRLQDAVKAMAEAEKLHKSKPDDPDADWFERSETLSDLLEKADIASKVAHSALVETSDALEAVQSTSVYTPKYPEVKNPQTASHPVVGLHLPAKRATGVQAALLGAGTSRPMGMEAPTRSKNAVKMAKRRQRQKESRQ
What is the function of this protein?
RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA.  May also contain guanylyl and methyl transferase activities (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, RDRP, Protein VP1.
What are the subcellular locations of this protein?
Virion. Note=Minor amounts are incorporated in the virion.
Protein: KAD_MYCLE
Sequence: MRVVLLGPPGAGKGTQAQRLAEKLGIPQISTGELFRRNIEKDTKLGHEAKKYLDAGDLVPADLTNQLVDDRLNKSDTVDGFILDGYPRSLEQAKALHEMLERRGTDIDAVLEFRVSQAVVLERLKGRGRADDTDDVVINRMNIYRDETASLLEYYSSELKTIDAIGTMDEVFARALHALGK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH_AGRVS
Sequence: MKVGIVGAGMVGSASAYALTMLGIASEIVLVDYNTDLAQAQAEDISHAVPFVSATLVRAGDYGDFAGAGVVIISAGVSQKRGETRLELLGRNAEVFRQVVDQVLAAAPNAILLIASNPVDIMTDIATRLSGLAPQRVIGSGTILDTARFRSLLGRYLEISPQSVHAYVLGEHGDSEVLAWSNAMVGAVPLMSFAKQAGKPVTDTVRSEIDAGVRHAADKIIKGKGATYYGIGAGLARIVKAIASDQRDVLSVSSVTAELAGVTNVAASVPRVIGSSGILMDLVPDLDETERIALAKSARMLKDLALSVPC
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_SORAR
Sequence: MTNLRKTHPLMKIVNSSFIDLPAPSNISSWWNFGSLLGVCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYMYLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSDLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAGVHLLFLHETGSNNPSGLCSDADKIPFHPYYTIKDILGVLLLILTLTSLVLFSPDLLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALALSILILAVVPFLHTSKQRSMMFRPFSQCLFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFLLILVIMPITSLFENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VRAR_STAAN
Sequence: MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
What is the function of this protein?
Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis.  Upon cellular stress, the histidine kinase VraS transfers the phosphoryl group onto VraR.  Upon phosphorylation, VraR dimerizes at the N-terminal domain.  In turn, phosphorylation-induced dimerization expands and enhances the VraR binding to its own promoter leading to increased expression and subsequent modulation of as many as 40 genes, which ultimately constitute the S. aureus response to cell wall damage (PubMed:12864861).  In addition, inhibits the host autophagic flux and delays the early stage of autophagosome formation, thereby promoting bacterial survival.  Facilitates the ability of S. aureus to resist host polymorphonuclear leukocytes-mediated phagocytosis and killing thus contributing to immune evasion (By similarity).
What are the official names of this protein?
Response regulator protein VraR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FGNE_ASPFU
Sequence: MTVAISNPAAPPVSARAYLSVIGGTCALLCTVGFVVAFGVFQGYYTEHLLRGMSEFDIPWIGSASIFLLYVSAPICGVLVDRFGPKVLLIAGSIGVLVAIFMISLCSQYYQIFLAQAVLLGISMGFVTWPPFAVVSRNLPHHRGLALGVITGGSSVGGIVWSIMIEELLTKRNLGFPWTVRVLGFTMLPLLAFACISITEPPKQSQPQPRPALEATVEGGSASPTPKPEYASLPLLRSTVFISICVGFGLAFLGLFNPFFYISSYAAGHGASAQTSSYMISIMNAATLFGRVIPGIVADRVGHYNVMIFVLLASGITSFCWTEVRSLTGLVIWSIAYGFSSGAILSLQGACAGKIATPQNQGKAIGFLQGSLAVTVLVGSPIGGQLLGHYGYLSLSMFTGATLVMGAVVMGYARLCLNRSPMEAHQFRFLLAPN
What is the function of this protein?
MFS-type transporter; part of the gene cluster that mediates the biosynthesis of fumigermin that inhibits germination of spores of the inducing S. rapamycinicus, and thus helps the fungus to defend resources in the shared habitat against a bacterial competitor (PubMed:32083553).  May be involved in the secretion of fumigermin (Probable).
What are the official names of this protein?
MFS-type transporter AFUA_1G00970, Fumigermin biosynthesis cluster protein AFUA_1G00970.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRD_ACTP2
Sequence: MYSLIRKCLFSMDAETAHNFSIQALKLAGKLPINVLPMPLNPVEVMGLQFKNPIGLAAGADKNGEAIDGFGKLGFGFIEVGTVTPVAQDGNPKPRQFRILEAEGIINRNGFNNLGVDVLVENVKKAKYDGIIGINIGKNAVTPIERALDDYQICLRKVYEHADYITVNISSPNTKNLRTLQYGEALDDLLRSLKSEQESLSQKFNRYKPLVLKIAPDLTDEEIASVADSLVRYKIDGVIAGNTTLSRDPVVGLKNAEQQGGLSGKPLNTLSTRLISTLAKELNGALPIIGSGGIHSVASGQEKIDAGASLLQVYSAMIYQGPALIQNLAKHIQVR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SYTL5_MOUSE
Sequence: MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTHQEASRVCVHCHKTLGLIFDRGDPCQACSLRVCSECRVTGLDGSWKCTVCAKVAQLRIISGEWFLEEKAKRFKQVNVLGTDVVRQSILRRSPGSEETQNQEQAQQCVDKSDTLSSVRQKTTHDGPKKKGFLLSKFRSATRGEIRTPKPESGRSYSLDLDSQNLQSFKSASGSDRGSTTSSDLIDQEAGRRTSKSSYSNGGIPVTQRSPVPSAHSVTSINSREHGFENSMALATIENTCEELTKSHRRNTSGTPSIAVSGTSLSSERSRSEVDLSESFAEDLEDTSSIRSRSVPGALDKDLNSLEDTEDGVDLVSSRFSANTHSLASGLSTNSQAGSDRKRSYLNVPDADSDTTSLNSMMSVYSETGDYGNVKVTGEILLHISYCYKTGGLYIFVKSCRNLATGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIAFDSWNFENPCDEWFVLQPKVELAPDISLQYKGELTIVLRYIPPEENLIFPAGQRQEKKIFKRGKKKESSSISGGILEVFIKKAKNLTAVKSGGTSDSFVKGYLLPDDNKATKHKTAVVKKSVNPEWNHTFIFSGLYPQDIKNACLELTIWDKEAFSSNVFLGGVRLNSGSGMSYGKTVDWMDSHGEEQRLWQKMADNPGTSVEGVLMLRSSMAKCRL
What is the function of this protein?
May act as Rab effector protein and play a role in vesicle trafficking.  Binds phospholipids (By similarity).
What are the official names of this protein?
Synaptotagmin-like protein 5.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: SSRP_PROM2
Sequence: MAKTSNKVKRNANKANIFKLLADNRYAKFQYEISETIEAGIELLGTEVKSIRNGKANLRDGYCSFRDNEILLLNVHISPHKNVGSFFNHDPLRNRKLLLHKKEIIKMKSSTEKKGMTIVPLNLYLKGSWIKLTIGVGKGKKLHDKRQDEKQKSIKREINSALKR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: NUSB_RALPJ
Sequence: MTQDNSQAKAKAPAKSARRRARELALQGLYQWLLNRNDPGVVEAHLQDAQGFNKADRAHFDALLHGAIREETTLTEAFTPYLDRPVAELSPVERAALLVGAYELVHCVDIPYKVVINEAVELTKTFGGVEGYKYVNGVLDKLATQVRAVEVAARR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: TRUA_EHRRW
Sequence: MRYKIVIEYDGSDFIGWQKQNHNSNSIQEILEKAIFKFSKQHVIVYGAGRTDAGVHALGQVAHFDLTTDFETYIVRNAINYHLISHAIAVVHVEKTDTDFHARFSAKRRYYLYKIVNRYSPLTIDRNRAWLVHTPLNVENMIKAVCYIKGNHNFSSFRAKCCQSKSPIKTVDNLSITYNHPYIDINISAISFLHHQVRIIVGTLVECGKGYFPPEHIKTIMEANNRSYAGTTAPSYGLYFVKVDYS
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: HSLO_CLOBA
Sequence: MNDKIVRATAKNGMVRIIGGITTNLVNEGSKIHECTPVAAAALGRMLTAGTLMGTTLKGEKESLTLKINGGGEAKGITITAHNDASVKGFIGNPYVTRELNDKGKLDVGGAIGKDGLLYVIKDLGLKEPYVGQVPIYSGEIAEDFAYYFTVSEQTPSAVSLGVLVDKDLSIKAAGGFIVQMMPDADELLADLVTYRLEEIPPITTLISEGKTIEEILEFIFEGMDLNILDSIEPSYKCDCSREKVEKALASIGKKDLQEIYDDGKNEEIVCNFCNTKYSFTTNDIGELLKNSIKK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.