Protein: KETN1_CAEEL
Sequence: MPFKQPLGERDAANRVAPTFIRPLADKRAVVGETIILECQLEGHPDPAIKWLKDGHNVSMCPDYRIEEDGLKHRLVIPQVQAADSGRFTAQASNSAGTKQSTCILICAPAPTPVPGAKSAVASPAPPQTPVGPSAPIFLKELRHQPLKPGAGVTFEGRVIAVPPPNIEWMKNGKPLQNYRAKIEHDQKTGIISLIIPQMFNDDAGEYTIKATNVHGEAISGAQLLPREQYDRWFSNEQTRLTKDRKQGLLSQTLRPSSVAQKQMQKQGYDTDQGSVDMHWTISESETEPELSALDARGVGTKPIIRTPLRGLRLTEGTDAILQANIVGNPKPRIQWLFNGRPLQVSGPRMQMTYKGSMAVLKISMVTTEEAGDYTVASENRFGKVESSARIEVYPLSVPDERRKENQLREQQERDRQQQQQALVEASLARERQRDAENRRIREEQDRLRVLFEREKAERERLEEERRQLEHEKRLRQQQQQQLFEREKSEKEERARLEEERRRLEHEKHLRQQQQTQPYNLHYQQHHQPHQAWQDLDLVRRPQYASDEYQEPHYAQIRPHQQQQQHYQQQQQSPRQEVTHQNLYEQHRRQQQLIREQQLYQHQHQQHQQQQQQPQEQQQQRFHHFNQYQQHIREQHQNTMPVFRQQQPTQVTNGGIKAANGSAKTANGSANGSANGSAVHAANGGPSSQQARGHEHGAALVNARPPQFLVHPQSVAAKAFETVTFSAKVVGTPTPSLTWQKSDGTVIQSGGKYKIENGPDGSGRLIIEKVDAHDADMYMLVARNDGGSFQSRFSLNVLQAKSPEAPEFTGKFQSTTLYDGDSVKLYCKAAGEGVSFKWFKDNEPISSGGSYAVDNKGNETTLHINNATMKEGGWYRCDATNKHGTTTLKGRVVVNSRQKFNGPAHREMITLRKVDKVERSRTPVNQLQDVSASKSSPKFEGSLQSQQLVEGQSARLEIKYTPVEDPNLRIAWLLNGKGILASSRIVTFTDFGIAALEINPVNVFDQGEYTVVAVNPLGEARVSANIAVIGHGSFIQQQQSGSQFGGTAYQSKGAQAPAGTHLDLPNFHSDLRSQEVFEGQQIHLETKLTPINDPDLRVVWLLDGNELPSNDKYRQTLSHGFASLDIPQTSSNDSGLYSCRAFNKLGESENQATIIIVPKSDLQQFEQHRQLDVEDVREIQFAHSSQDLTPKFLSQIQPFHCEQELGRSFFEARIQPINDPTLRVSWLKDGQPLPNANRIQIFQNFGVVSLSLHPTYPEDAGVYTCVLFNSHGQAQSSAELTTVWIDTLQLDSKHADSLPIIGYLDSHQIHIGPQSVERPEEFNSLEAPKFARELAGKIEVMENERVHFEARILPANDVKMTVEWYHNGNPLPAAHRFHPMFDFGYVALDLLYAYPQDSGTYTLVARNELGEARSNVELVVGTEKVLYLEPHHPEGLERIKELEQDRRQGIAEVEDRTCDAAPKFLNDLPDIQLNEHENIHVDLRATPVNDPTMVIEWFVNGRPLLTGSRVKTLNEFGFIALDIKGAIAEDSGTYSVRASNLLGEAIRQCVITVTPAGQILSDTQHQESLGKINYLENLNKYGRVEIEDKGPQEPPTFVVPLQADLGDVEEGEPIHLECQVNPINDNSLKIIWLRDGQSLPHGHRFRTFYDFGFVSLDILGFYAQDAGTYTCRAENSLGQAETVATIRCAPKDAILGAVQHPRSYARIQEIEAPKPAPQEVPDLPHQPPAFVKQLGPAIQCMEGDNVYLEAQVTPTDDNSLTYEWLVNGQPLMKAHRFVLSQDFGYIALNILYCYPEDNGTYTLVVRNRAGEAQSTVDINCGHTGGNFTDSFHPNSLHRIAELETPIQRAEPLPDKEKEVPTIAKPLPATIDSVHESQTLHLEAQVTPIDDNTLRYEWLFNGNPLKASSRYRVLNDFGFVSLDIDYIIAEDSGKYTLVVYNSAGRAETSCEFQVDRLKSILSDTAHPESLRRIREMEQLQPAKPSDDDAAAQPPVFTQQLTGPTEPLKEGQSVHMDCVVQPINDPSLRIEWFHDGRPLMFGSRIRTIHDFGYVGLEFLHIHPEDTGTYTCKATNLIGEATTDIFLECKPRRNIYLDTHHESSWQKIQEIENRVDEREPTPELTFQPPTFTENLADKEDAQEGQSIRLECRLIPVNDPTMRVTWTRNGQPLPEASRFMPARNFDYVNLDILALYGEDSGVYTCKAVSAFGEAATSCTVKCAAGKSLLLDTMHDASWKRVQEIENREKLEAVDAEPEKTAPKFVTQLNSSLGELQEGVPIHLEAQVEPTNDNQLTVQWFHNGQPLANGHRFRTRHDFGYVALDILYAFAQDTGEWACVARNSLGEAQTIANFTVLPRGTIYTDSQHPESWQKIQVLEAPRAAAPEKPDAEHDAPQFIEPLDSIDRMEFQSAHFQTKVTPQTDPNLRIQWFKDGQPLMNSNRFKLTTDFGYISLDIAHTVPEDSGVYSVKASNAKGDAEVQAQLTVTGNAVILGDTQHEQSWQKIQLIEAPRAPGEEEPDVKHGPPKFVTQLHSLDGVVEGQPSHFEAQFIPFSDPKTSVQWYLNGNPLSASSRRILRNDFGLVSLDLQYTLGEDAGEYSVVVKNSEGEDRTSGQLSCTTRAAILGDTQHEQSWQRIQEIEAPRAPGAEPEGPVYEKPSFVQPLQSVGDLPEGSVALLEARLVPVNDPNLRVQWFYNDQPLMESNWISTSNDFGCVSLRIAPVYARHTGVYSCKAWNDSGNAVTSANVGVQGSEGLLLDTSHPASLQKIQELEAIDKYARLDAPEREYEKPQWVQGFENYENVGEGQTVTLHGLVEPSGDPHLRLEWLLNGTPLRNANRFRQEYEFGNAILTIVHVLPHDSGVYTCRAWNTQGEASTSATVTTAGYEKILYDSQHPVSWERIQELEAPKIVEEIEEIVQKEKPNFLTQLESAENVPEGVPLHLESTFQPARDPELKVVWQKNGQPLGASQLVQTKHELGWATLDISSANEDHNGVYTLTITNSEGEAVSTASIRVAGTGPILGNTRHEESWKRIQILEAPKEAEPEAPAPVYDHPAITTQIDDKECNEGDHVHFEALITPVNDPRLQVQWIRNGVPLAHGSKYAIQQDFGICTLDVAYTYPEDEGVYQLRIWNPEGEAVSSATLKCHGKDAILGDVQHQESWKRIQEIEAPKQKLEEADPEPKGPPRFIQQLTSPGSLVENQPAHFEATVEPVDDPTLTINWFLNGEPMSASSRVKMINDFGWVIMDIAQTEPRDSGEWKCVAKNAAGEAVSTATIEVQGKEVILQDSLQPQSLDRIRQIEAGKPAPEERPDQQFEAPAIVNALQVQGALEEGGSAHLQTQFTPVADPSIKVEWLKDGQPIFHSNRYKMVHDFGFAVLDILHLLKHDAGEYTFRVSNNSGEASTSTSFEVSESSGLILQPQNEQKAKAVEILEDNLRRRPEEIEQELKEATPVFIEPLSAPVETEEGGRAHFTARYEPVNDNQLQVQWYHDGRPLKNGSRIKTINSFGYVVLEISPTYPEDNGEYICRAVNRVGEAVTSTKLTCTPKEGIISATQLPERMANAGRRIAEIEAPRPAREDAPDADHGPPKFTSALAGPPELQEGQQAHLECQVTPVADPRLVIEWFHNGQPVNHTNRMKAIHDFGFVVLQLTPAEPQDSGTWTCRATNQHGSDEVSTELKVVGGGGVSYEWQSTAERKERITELEDWIHRPKEDLNLPAVDYPAPSFSQGLTDLGQLNEADATAFVCVLEPIGDPTLRVQWEHNGHPIPYSNRISCTNEFGVATLLIKHLIAADAGEYKCVATNVKGSATSVGKIAVESSTQIDAPQVVQQLVDSVENILEGDSIHLECRVTPINDPRLHVEWLRNGAPLPEASRFKPTFEFGFVSLDILYAYPEDNGDYELVVRNDKGEARSKTKITVLPRPSLDYTSQTHGNQQDSLESHFKQHSQAKLQLTANDIYNESDKRAPEFRTQLQNIGVLEGEFCRFETQVAPINDPYLKVEWFKDKKPVLLGHRFRSTLDFGFACLDLLYALPDDTGEYHCVATNRHGQTMISAKLACQGASHVITDSQMPQGLRVSNVKKDNKNIYWSEQGGAVQPKQKQAPQFTIPLRNLQVTENQPARFECAVTGYPRPKVTWFINGNQCLHGHRFKLNFDGLHYLTVSKSRISDAGEVVAIARNTEGETISTATLDIFQNDDFRQTKLRPANFKTSDELRERELQWQRDTLGSLGPAFEAAPKPDAQKLMHVERAQSPIEPMESQELIQKFTRPRDDNFYNKLSYVELQKPQFKGMELEEVNLKAGKVEKYQPPVEEMERVNLKAIPEKDQQEVGWERPDWAGQDGTSKLPGADEGRFKKLPTPAPELDVPARDQVKLKTAKPTRGKDLEAGEKVKLKTEKAKIKEIQQKPEQPKEEPIVHKDAVQLKTQQLPKTGIKGDHFTVDREKDLKETPAVVKPVIEETRISNKSISNVVHESSEYTSSYASNQSRLTYQAYREHKESTSSDVYLSVETADSFSQVQRLEYSPRSPRRERIIGFHMIRPQPTKIGQSKQAPPTISQQLKPLQGELGKAAKFVIEFAGAAPVKVTWLKDGKEIKSTFRTLITTTPTNSSLHIGRLENSHAGEYTVRLENAAGTVESLANLTVAPPTTQGKAPDFSARLNDLRIQQNGPAEFSCQIGGEPKPTIQWFKDGQPLPNDDRFQVVEEGGAYKLKFSNIISTDAGIYEIVAKNGVGEARCKARLNVNLQKTGKGAEEGPRYEAPRFTSQIQPIVVDEGKGAQFSAQFSGFPDPTIRWYRNNEPVKHADGYEISQSKGEAILRISAARNEDVAEYKVEASNPAGKASSVANLVLTPRSGRIAKSTISRGGSASYQSSDKAAADSPHFIAKLSDISARQGHTVKFSAEVDGNPEPTVQWQFKGKPISASNNVKISRDGKRAILELARVTPDSAGEYQIVIRNDKGAATSQAKLTLSR
What is the function of this protein?
Positively regulates actin filament organization and provides mechanical stability to the myofibrils during body wall muscle contraction (PubMed:16597697).  Required for the organization of sarcomeric actin filaments and myosin protein myo-3 in striated body wall muscle cells (PubMed:31411810).  Not required for assembly of dense bodies, which are a type of integrin-based adhesion structure that link the plasma membrane to thin filaments of myofibrils, in body wall muscle (PubMed:31411810).  Not required for the atn-1 protein to localize to the dense bodies (PubMed:31411810).
What are the official names of this protein?
Kettin homolog.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Note=Localizes to sarcomeres in a punctate pattern (PubMed:31411810). Localizes to actin filaments (thin filaments) close to dense bodies in body wall muscle (PubMed:16597697). Co-localizes with actin filaments in embryos and adults (PubMed:16453162, PubMed:31411810).