PharMolix/UniProtQA huggingface dataset:
Protein: RSMA_MALP2
Sequence: MIGKEENKFISFIKKNKFFASRKMGQNFLINENIKKKIVDSLEIKPDDHVLEIGPGFGALTKIVLSQTKNLTVVELDKRLVEFLKQEYKELRIINIDVLKFDFKEFNKDTQYKIISNLPYSISSKIIFKILKYANFSQSVLMVQKEMADRITAKVGTKKYNNFTVLLRITSEIKKLFDVSNNCFFPKPEVDSTVISFERKKDFDFTNFEKLESFLLKCFSQKRKTIFNNLKNYFPKQKIEEVFNKHSIIPTTRPENIKEELYLKMCFDFYDL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_SACEN
Sequence: MTARIDDTAAEENPRAVARARFVRVTPMKARRVVELIKGRSASEALAVLQFAPQAASGPVSKVLASAVANAENNLSLDPDTLWVHRAYVDEGPTLKRFRPRAQGRAYRIRKRTSHITVEVESRPKKVASKSKSQKGSAR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: KAD6_DICDI
Sequence: MNIKRNKPNILITGTPGTGKTSLAGVIASNNEMNHIDISSAVKEKELHDGWDSEFQCYILDEDKVCDEFEDVMVKGGNVVDHHGCEWFPERWFDLVIVLRTDIKILNDRLEKRNYNQHKITNNLDCEIMQVILDEARNSYKQEIVVELPSTTLEDNENNQNFISQWIQNWYEKNN
What is the function of this protein?
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.  Has also ATPase activity.
What are the official names of this protein?
Adenylate kinase isoenzyme 6 homolog, AK6, Dual activity adenylate kinase/ATPase, AK/ATPase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK6 subfamily.
Protein: MARH3_MOUSE
Sequence: MTTSRCSHLPEVLPDCTSSAAPVVKTVEDCGSLVNGQPQYVMQVSAKDGQLLSTVVRTLATQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLEHWLSSSNTSYCELCHFRFAVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLATISGWLCLRGAVDHLHFSSRLEAVGLIALTVALFTIYLFWTLRRYGHQSKPFWNQSSRS
What is the function of this protein?
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking.  E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
What are the official names of this protein?
E3 ubiquitin-protein ligase MARCHF3, Membrane-associated RING finger protein 3, Membrane-associated RING-CH protein III, MARCH-III, RING-type E3 ubiquitin transferase MARCHF3.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Protein: KEFC_SHISS
Sequence: MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLWKLRAAVFGGGALQMVICGGLLGLFCMLLGLHWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAIPLVAMIPLLATSSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQVPNKQRRWFAVLLGQGSEFAFVVFGTAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQPRVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLTEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAMVENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS
What is the function of this protein?
Pore-forming subunit of a potassium efflux system that confers protection against electrophiles.  Catalyzes K(+)/H(+) antiport.
What are the official names of this protein?
Glutathione-regulated potassium-efflux system protein KefC, K(+)/H(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LPXA_AGRVS
Sequence: MTVIPASARIHPSSVIEDGAVIGENVTIGPFCHVGSKVVLGDGAEFLSHVVLTGKTVVGKNSRIFPNAVIGGEPQSIHHSGEETTLTIGDNCTMREGVTINCGTVEGGGHTVVGSNNLFLANSHVAHDCQLGNHIILSNNVMLAGHVKIGDRAILGGGSAVHQFTRIGRQAFIGGLSACSYDVIPYGMLNGNPGLLGGLNVVGMTRAGVERATIHRVRKAYKALFDEEGAIREKAAAIREEFADCAEVIEILDFIVAESDRALSSPFRGKS
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIG17_CAEEL
Sequence: MHTFCILIPTFLVLVWTTESARREKQQSNDISFVKRKVQDGLKFSRVIKYTNETIQGMKTNFNSNKTQELSLDVLVVADFLSYQAFLEMSNGDSHRAIHNLKEYLHALFEQTKIIYDGISFGNETLHMVFAGTWIATQERDCPLWISWAEEEEERVLNEEIRRLEEKERDLNSTFVDDTFFMNSTDSDNSSTDALISSDMPKKLRKFVDITLEEMQENNSTEMTLKIDSKKAIDKFTIWLKEQTGLPRHEHAVLITKFDLISINGNSATQGMAYVGNICENGDSSSVVEDIGAGLTSLIMAHEIGHSLGALHDGAYETAECDSNDNYLMAVAVSGSADRQSFLNSRRMSNCSINSIIENLKEPTANCVKKWKTKKGKDVSQKDFIKKPGELVKITRQCQVAFGPTFIPCLHIGYFHEQSICERIWCSDGESDECQTLNYFPAFDGTECGYNMWCLEGSCVQNTKKWMDCKDINSKTCSKYSTSKLKHYCKSKDFREICCRTCAKKGKIY
What is the function of this protein?
Metalloprotease (PubMed:17491590, PubMed:18637819).  Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis (PubMed:10864868, PubMed:15556863, PubMed:17491590, PubMed:19104038, PubMed:24318535, PubMed:26994289).  Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane (PubMed:19104038).  During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length (PubMed:26994289).  Does not recruit fbl-1 to the pharynx basement membrane (PubMed:26994289).
What are the official names of this protein?
Metalloprotease mig-17, Abnormal cell migration protein 17.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Secreted as a zymogen (PubMed:17491590, PubMed:18637819). The zymogen localizes to the basement membrane of gonads, intestine and hypodermis (PubMed:17491590, PubMed:18637819). The mature and active form displays a similar localization but only during the L3 larval stage (PubMed:18637819).
Protein: GLYA_BACC7
Sequence: MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRVKEIFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDAESHRINYDDVLAKAKEHKPKLIVAGASAYPRVIDFKRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEEQFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIINNANRLAEGLQKEGLTLVSGGTDNHLILIDVRNLEITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGTAAVTSRGFGLEEMDEIASLIAYTLKNHENEAALEEARKRVEALTSKFPMYPNL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSA_SHESH
Sequence: MSTQSLYKVSSEIAENAHINEEQYKKMYQESIVNPEGFWREHGQRIDWIKPYTKIKKTSFDDHNLSINWFYDGTLNASANCLDRHLEKDSDKVAIIWEGDDAKDQRTITYGELHSDVCKFANALRSQGVRRGDIVTVYMPMVPEAAVVMLACARIGAVHSVVFGGFSPDSIASRVIDGKSKVIITADEGVRGGRIIPLKANIDEALSHPDVDCVEKVIVLERTGGDVNWVEGRDIKWESLMDTASEHCIPEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKDGEVYWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNYPTPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFADFDGSSLRIMGSVGEPINPEAWRWYNEVIGHEHCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNMGNIIDGATEGNLVILDSWPGQMRTVFGDHDRFALTYFKTFRGMYFTGDGAKRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHEHVAEAAVVGYPHDIKGQGIYAYVTLTKGTIETEELRQELRKWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVTNLGDSSTLADPAVIDTLIESRLNRSE
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CFDP1_RAT
Sequence: MEEFDSEDFSTSDEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQAEKTKGKRRKAQSIPARKRKQSGLLLDEEEDGEEDSGGSSREEDEEEQEGGLGSETSRKKKEDELWASFLNDVGTKSKAASSSQVKVAEETEETSSSKPLVKADELEKPKESEKVKITKVFDFAGEEVRVTKEVDATSKEAKSFLKQTEKEKPQALVTSAATPPPAGSGIKRTSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLERVDHRQFEIERDLRLSKMKP
What is the function of this protein?
May play a role during embryogenesis.
What are the official names of this protein?
Craniofacial development protein 1, Bucentaur.
What are the subcellular locations of this protein?
Chromosome, centromere, kinetochore.
Protein: ARCA_STRPZ
Sequence: MTAQTPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQALRDEGIEVLDLETLAAESLGTPEIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQELIEKTMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHMFSETRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRVYSVTYDNEELHIVEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIAPGVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNPH_SACS2
Sequence: MNPVHILAKKGEVAERVLVVGDPGRARLLSTLLQNPKLTNENRGFLVYTGKYNGETVSIATHGIGGPSIAIVLEELAMLGANVFIRYGTTGALVPYINLGEYIIVTGASYNQGGLFYQYLRDNACVASTPDFELTNKLVTSFSKRNLKYYVGNVFSSDAFYAEDEEFVKKWSSRGNIAVEMECATLFTLSKVKGWKSATVLVVSDNLAKGGIWITKEELEKSVMDGAKAVLDTLTS
What is the function of this protein?
Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.  Cleaves inosine, guanosine, and adenosine with a better efficiency than MTA.
What are the official names of this protein?
Purine nucleoside phosphorylase, PNP, 5'-methylthioadenosine phosphorylase I, MTA phosphorylase I, MTAPI.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: TM147_RAT
Sequence: MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLCSLGSWTALLARAVVTGLLALSTLALYVAVVNVHS
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.  Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane.  Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity.  Regulates LBR localization to the nucleus inner membrane.
What are the official names of this protein?
BOS complex subunit TMEM147, Transmembrane protein 147.
What is the protein family that this protein belongs to?
Belongs to the TMEM147 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: MNMG_FRATT
Sequence: MIYDYGYDVIVVGGGHAGVEAASASARIGAKTLLLTHNIDTIGQMSCNPAIGGIGKGHLVKEIDAMGGVMAKAIDMAGIQFRILNSRKGPAVRATRAQADRLLYKKAINSLINNQENLDIFQDSVDDLVVENNTVCGAITKTGITFRAKKVVLTVGTFLGGKIHIGKVSNAGGRAGDQPSNALAARLRSLPFRVDRLKTGTPPRIDRRSVDFSVMEVQHGDNPTPYFSFFSKGKIEHPRQIPCYITYTNNETHKIITDNLDKSAMYSGLIEGIGPRYCPSIEDKVVRFADKERHQIFVEPEGLNSIELYPNGLSTSLPFEVQCNYIRSIKGFEKAFIMRPGYAIEYDFFDPRDLKPTLETKHIKNLYFAGQINGTTGYEEAGAQGLVASINAAISIDSDKSWYPTRADSYIGVLIDDLITKGTKEPYRMFTSRAEYRLILREDNADLRLSNKACELGLLSKEDQQHFISKKNAIIENIAMMKNTWIGPQTQKARDLEKFLDKKMTRESTLFDLLKRPEIDYSKLQQISELNLNLQDDAVIEQIEISAKYSGYIERQNKDIEKTATFEQKAIPTDFNYSQVKGLSNEVLQKLTEQKPTTLGEASRIPGITPAAISLLTIYMKKTGFIK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOBA_RHOBA
Sequence: MRNELTAMPHAAPPPLLGVLLAGGRSSRMGTPKALLPHPSGGTFLTHSLDRLRLVCEEKIVVSLASEAHRAQVQLPPSVPALFDSQPALGPAMGVSVALQHASSNGFAGCLFTPVDLPDLSVDDLLSLVHAWRESPTQIVLAQQTDPERLQPLVGIYPVACMDSIQRVVESEHRSLYRSLRSSDHQTVAIPSTRLRNVNTPADLGPPFDST
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Probable molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLX1_DROAN
Sequence: MSFRKFTATADPEKDETIARKGHFYGVYLLCSQSLDSRYRGKCYVGFTVNPKRRIKQHNRGCDFGGAKKTSRKGPWQMVMIVHGFPNNIVALQFEWAWQQPTLSTRLKIFPELKRKNPRESHFDYNFRILNRMLGVGPWNRLALKIRWLETDYERGFEVPLPRHMEIVSGKVSISSSQRRKGEDAAATVPVAWAPECHLCMQRIDQPERSRLGCTNPTCRLTCHMLCLANYLLGDEPGHYIPVGGECPLCETRLSWSALLQRKRLLNGIPEELLDQEEADEDLSDGPDVDSDVEVLESD
What is the function of this protein?
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1949_SYNY3
Sequence: MTSYSSATARAEMSELRRLKSLLPPELQSWVMVEGSTEVNPPLIRSEELGRDEIEIQVDLAKWENLAIDQRNLLFWHEVARIQSDTIPREGWEMAALAIGLGGAVGELWVQDGLLLLLALGLCGISGYRLWQKNNGEKRIKEAIEADEKAITLATRFGYTLPNAYKSLGSAFKTLIEQTPNRRQRKQYETRLQALRQSAAKMKAKTQKAKAL
What are the official names of this protein?
Thylakoid membrane protein slr1949.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PGS1_RAT
Sequence: MRPLWLLTLLLALSQALPFEQKGFWDFTLDDGLLMMNDEEASGSDTTSGVPDLDSLTPTFSAMCPFGCHCHLRVVQCSDLGLKTVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHSNNITKVGINDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQFGNYKK
What is the function of this protein?
May be involved in collagen fiber assembly.
What are the official names of this protein?
Biglycan, Bone/cartilage proteoglycan I, PG-S1.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: Y1093_YERPA
Sequence: MNRKKIIVAAVIVALLATLAYGWHYYRQQNDASLTLYGNVDIRTVNLGFRVAGRLASLAVDEGDDIHPGQTLGKLDDGPYLNALKQAQANVQSAQAQLALLKAGYREEEIAQVRSEVAQRQAAFDYADNFLKRQQGLWASKAVSANELENARTARNQAQANLQAAKDKLAQFLSGNRPQEIAQAEANLAQTEAELAQAQLNLQDTILLAPSAGTVLTRAVEPGTILSASNTVFTVSLTDPVWVRAYVSERHLGQAIPGSEVEVFTDGRPDKPYHGKIGFVSPTAEFTPKTVETPDLRTDLVYRLRIIITDADESLRQGMPVTVRFPQR
What are the official names of this protein?
UPF0194 membrane protein YPA_1093.
What is the protein family that this protein belongs to?
Belongs to the UPF0194 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ARSM_RHOPA
Sequence: MPTDMQDVKDIVREKYASAALKVATGGASCCGSSALPGASPITSNLYDAAQEQGLPAEAMLASLGCGNPTALAQLSPGETVLDLGSGGGIDVLLSARRVGPTGKAYGLDMTDEMLALARDNQRKAGLDNVEFLKGEIEAIPLPDHSVDVIISNCVINLSGDKDRVLREAFRVLKPGGRFAVSDVVTRGEIPEALRRDVLLWVGCLAGALDEADYVAKLAAAGFAQISIEPTRVYDIEDAREFLTGKGIDVDALAPQMQDKFFSGFVRATKPGADGEVPARCCG
What is the function of this protein?
Catalyzes the transfer of a methyl group from AdoMet to arsenite, producing methylated arsenicals.  Involved in the conversion of As(III) to a number of di- and trimethylated species, with trimethylarsine as the end product.  Reduces the arsenic toxicity in the cell and may contribute to the global arsenic cycling.
What are the official names of this protein?
Arsenite methyltransferase, As(III) AdoMet methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.
Protein: MAZG_MYCTU
Sequence: MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR
What is the function of this protein?
Required to maintain the full capacity of the mycobacterium to respond to oxidative stress via the degradation of oxidation-induced damaged nucleotides.  Hydrolyzes all canonical (d)NTPs, as well as mutagenic dUTP and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP).  Also involved in the transcriptional activation of RelA in response to oxidative stress.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphohydrolase, NTP-PPase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside triphosphate pyrophosphohydrolase family.
Protein: RSBW_STAEQ
Sequence: MQSTQDYIEMRLPASAEYVSLIRLTLSGVFSRAGASYDDIEDSKIAVSEAVTNAVKHAYKKNSEIGMINLCFEIFDDRIKIVISDQGESFDYEATKSHLGPYNDNENIDFLREGGLGLFLIESLMDEVTVYKESGVTISMIKYIKKEQVRNNGERVEIS
What is the function of this protein?
Negative regulator of sigma-B activity.  Phosphorylates and inactivates its specific antagonist protein, RsbV.  Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
What are the official names of this protein?
Serine-protein kinase RsbW, Anti-sigma-B factor, Sigma-B negative effector RsbW.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: UVRC_HYDS0
Sequence: MDIVALIEKAPEEPGVYIFKNQKHYIYIGKAINIKKRLLQHLKEREQSKKEANIFNHSKELEWIVTRNEYEALLLEMDLIRTHKPKYNVLLKHGSGYPVILLTDDEYPTVKITRDTSEKGEAFGPFLNINKALKIKKLIHATFRLRTCEEMPKRPTPCMDYHLGLCSGPCANLISKEDYAISVKSAKAFLSGNVKDVLPTLYEKIEQYASNLAFEKAAFLRDQVLVLQNIVDGQGVFLYDIEEVDVFYLEGYSLWLFIIRNKRLVAHKEFRLNKELIINYEEMLGTYYMSNIVPKKIVANFELTENFRLFIKSKRKDVAFSNNIPKPLLKIIEKNVVLKPDTKEFESEFYKLFGRKAPKLIECFDISHFQGQYTVGSMVVWEDGSLNKSKYRRYRIKTVDYIDDFASLKEVLSRRAKRIVSKEDQTPDMWLIDGGKGQLSMGIEVKEKFLLNIYICSLAKKEEIIYTEDGLEIPIKNHQALYRVFGLLRDEAHRFAITYNRNLRSKEFIKDTLSKIKGVGKVKKEIIYRHFDSLYDFIKSDDEKLKKLGISKSIKESVKKILGDM
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRI_THESM
Sequence: MKELKVSAINKGTVIDHIPSGKGLKVLEILNLPEDNTILVAINVKSQKLGRKDIIKVEGKILNEDEVNKIALIAPTATVNIIDKWEVVEKRNVEVPDEIVGIIKCANPNCITNYEEVKPKFKVISKKPLKLKCHYCERTMEENMVVKNLL
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: SYA_LEPBP
Sequence: MKFKTVQEIARLYTNYFQDKGHTIVPSSSLIPKGDPTLLFTTAGMVQFKPLFTGAVELPYTRAASVQKCVRTTDLEVVGKTERHCTFFEMLGNFSFGDYFKKEAIEYALDFSLNHLEIPKDKIWVTIYLDDDEAKKFWMDLGIPEERIVRLGKKDNFWGPAGDSGACGPCSELYLDRGPEKGGPTCGNNPNCKPGCDCDRYLEYWNLVFNQFNQTVSGELLPLKQTGIDTGSGLERVAMLLQEVDSVYDTDELKSIIKQIEILSGYKYDETTKQSFRVITDHSRSVFFSLGDGIYPDRTGRGYVIRRLIRRASLFARKLGIHEPFLYKLVSTLKDLYSLRYPELKDKAKDIESILKKEEELFLHTLEVGLEELETVLEHLKKEKQTVVTGKEGFRLYSTYGFPREMTKELVEERGFSFDDKGFEEELEKDRYLSRASWKGKKIQYLTGFSASPELKTEFLGYTETKAKSRVLHLFVDGKSVTSTKQGEEAVIVLDKTPFYAEGGGQIGDTGYLKKEGFQFQVQDTQKENDTFLHMGMILKGNLSVGDVVDSEIEVERRQNLANHHSGTHLLNGALRRILGSHVTQKGSIVSADYLRFDFSHPKALSKEEIIQIETDVNEAVSANIPVKTEVLEIGQAKESGALSMFDEKYGSVVRVISMGDKSKEFCGGTHVSNTKEIGFFAIVKEGSPGAGNRRIEAICGESVVNYFLHQFQTLASKIETHNLSAKETFGDLKEFGITKEVPSPEILQTMFHQDGKEVVTRLRKLREELEIELEEKSSALFKAKKKREQKEFQMNPELVDGLLQKAHHFPKGKVVTEVFPSVDAKSLKDLADSLKAKEPEILCLFGTTEGESSTLVFMCNKVLNERGIHCGDILKETLVMLDGKGGGRPDMAQGGGKKPESVAKSLEFALSLAKIKLS
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIHI_ECO45
Sequence: MKPSSSNSRSKGHAKARRKTREELDQEARDRKRQKKRRGHAPGSRAAGGNTTSGSKGQNAPKDPRIGSKTPIPLGVAEKVTKQHKPKSEKPMLSPQAELELLETDERLDALLERLEAGETLRAEEQSWVDVKLDRIDELMQKLGLSYDDDEEEEEDEKQEDMMRLLRGN
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.