PharMolix/UniProtQA huggingface dataset:
Protein: Y2320_ACIBC
Sequence: MLAQFYVNLVVLLVLLICGLLSQNAAVTIAAGVLIVIKITPLNQFFPYIQAHGLNLGILILTIGVLTPIASGKLSGESILKSFISFKSLVAIAIGLLVAWLGGRGVKLMSSQPDVVAGLLIGTVAGVALLRGVPVGPLIAAGLLSLFIGK
What are the official names of this protein?
UPF0756 membrane protein ACICU_02320.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DER_PSEE4
Sequence: MVPVIALVGRPNVGKSTMFNRLTKTRDAIVGDLSGLTRDRQYGDASWQGRSYILIDTGGITGDEVGMDEKMAEQSLMAIEEADYVLFLVDARAGMTAADQMIAEHLRKRNKEAILVANKIDNIDADVARAEFSPLGMGNAIPVAGSQGRGINALMEAVLGHIPRDPVEDALDEDVAEGEEATRIPGPSEKDGIKIAIIGRPNVGKSTLVNRMLGEERVVVYDQPGTTRDSIYIPFERDGEKYTFIDTAGVRKRGKIHEEVEKFSVVKTLQAIKDANVVIFVMDAREGVVDHDLNLLGFALDAGRAVVIALNKWDGMEPGERDYVKTELERRLFFVDFADIHFISALHGTGVGHLYKSVQAAFMSAVTRWPTSRLTQILEDAISVHQPPLVNGRRIKLRYAHLGGANPPLIVIHGNQTDKIPNSYSRYLENTYRRVLKLVGTPIRIEYKGGDNPFEGKKNTLTDRQVNKKRRLMSHHKKAEKKRRDKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ERO1A_DANRE
Sequence: METCVLLLGLFLTSVHVTTAGSAAHRCFCQVTGTLDDCACDVETIDKFNNKDIFPKLQKLLSSDYFRFYKVNLNNGCPFWTDHSQCGLKYCAVKPCSPDEVPEGLKSSSYKYSEKASHDTEECEKAEKLGAVNGSLSDETRQALEEWKKYDDESDRFCMLDDEDSPESQYVDLLLNPERFTGYKGAEAWRIWNSIYEENCFKPYSVNRPLNPLASNSGDDGQGFYRWLEGLCVEKRAFFRLISGLHASINIHLSARYLLDENWFEMKWGHNVSEFQQRFDEDLTKGEGPKRLRNLYFLYLIELRALAKILPYFERSTFQLYTGQDTQDDQNKKLLLELLHVAKSFPLHFDETALFAGNNKEAMKLKEDFKLTFKNISRIMDCVECFKCRLWGKLQTQGLGTALKILFSERQIEAMPNKQHQSIISAQSAGNCVFVQRFRKNLHKCQRVEELQIVVVETQTVTVKMFQERATVQTDMHKHMTFPMFGYIQ
What is the function of this protein?
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum.  Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation.  Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell.  Required for the folding of immunoglobulins (By similarity).
What are the official names of this protein?
ERO1-like protein alpha, ERO1-L, ERO1-L-alpha, Endoplasmic reticulum oxidoreductase alpha, Endoplasmic reticulum oxidoreductin-1-like protein, Oxidoreductin-1-L-alpha.
What is the protein family that this protein belongs to?
Belongs to the EROs family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Protein: ARGJ_HETP5
Sequence: MYKSITTLLKQQPQSILRNYSTDKFPRGFKTGTAACGLKKTGNKDICIIHSSAPCNVAAVFTENKVKAAPVLLSKQLLETNNYKGFNSLVINSGGANACTGEQGLKNAKTMSNLTSSLLKAPQASLVMSTGIIGQQLDMSKVEKGIADAVTTLNESDWISAARAIMTTDKVPKLAQKSVSLNGGEVHIVGICKGAGMIHPNMATMLCTVCTDASISEDCLRALLKHSVHYSFNSINVDGDMSTNDTVAIFANGSAGNKHITDTTSSDFLQLQEAVREVTTRLAQMIVRDAEGASKFVTIKIHGADTEQNGHIVANSISTSSLVKSALYGEDANWGRVLAAVGYSGVDIDPLKVCMWFAKGDGKDVGLGKKNDPETSMQFLEKGTPLAKDENKAAQLLSNNDVAIVVELGMGKASSTMWTCDLTEEYVRANSHYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
Protein: DLT1_YEAS7
Sequence: MSGFAKLKSWLYKASLFVSLILLIGFSVVLPIDSIAQASKSENNAFNTFIVVGALVVFGVFCIFIIIGRMLFHKSCLKDIPRRYIPITPADLPHRSSREAVLQNMERSKELTILLKKPKDPVIHDGLEPPRRCDYPLDEKLFPEYLNYADCIKSLTDRLKYHGLFLNNLDVRMNLEDTFADVVNSQFVNHNANKIQLEKAKEFIDLYETIRFSGKDVTRDQFIKFVKFCLYFGEVSLTRDTSFANLHNFKLNGSSNNIGRTESKYSINPFDENEYAQDDMHYFPEPPTHLVRESSISTVARHVSSGVDLTNSEEHPLDTDSDCNALRLKLSKADSYRSVIRH
What is the function of this protein?
Required for growth under high-pressure and low-temperature conditions.
What are the official names of this protein?
Defect at low temperature protein 1.
What is the protein family that this protein belongs to?
Belongs to the DLT1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNAK_ACIF5
Sequence: MAKVIGIDLGTTNSCVAVMEGDKVKVIENSEGKRTTPSIVAITEEGEVLVGEAAKRQAVTNPENTVYEVKRLIGRKFDDAEVQKDLKHVPYKVIKADNGDAWVEVRDKKYSAQQISAFILQKMKKTAEDYLGEKVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAFGEDKKPGDSKIAVYDLGGGTFDISIIEIAEMEGEHQFEVLSTNGDTFLGGGDFDSRVINYLADSFKAESGIDLRGDRLAMQRLKEAAEKAKIELSSAQQTDVNLPFITADQSGPKHLNMKLTRAKLESLVEDLIDRSMAPCRVAMKDANLATSRITDVILVGGQSRMPKVQEKVKDFFGQDPRKDVNPDEAVAIGAAIQGAVLSGEKKDVLLMDVTPLSLGIETLGGVMTKLIEKNTTIPTRKSQIFSTAEDNQSAVTVHVLQGERELARDNKSLARFDLTDIANAPRGMPQIEVTFDIDANGILHVSAKDNQTGKEQSIKITASSGLSEEEIKRMIQEAEAHAADDKKARALIEARNEADASVHGARKAVEEHAAAPEHDKTKVTEAISAVENAAKGEDVEAIKGAVATLMAAMSALLQSAAAGQAQAESGAGAQGNAKPDDVVDAEFEEVDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: EV45_HHV1M
Sequence: MPLRASEHAYRPLGPGTPPVRARLPAAAWVGVGTIIGGVVIIAALVLVPSRASWALSPCDSGWHEFNLGCISWDPTPMEHEQAVGGCSAPATLIPRAAAKQLAAVARVQSARSSGYWWVSGDGIRARLRLVDGVGGIDQFCEEPALRICYYPRSPGGFVQFVTSTRNALGLP
What is the function of this protein?
Important virulence factor of HSV neurotropism.  Seems to be required for glycoprotein B-induced fusion.  Dispensable for growth in vitro (By similarity).
What are the official names of this protein?
Envelope protein UL45, 18 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae HHV-1 UL45 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Note=In transfected cells, it is retained within the ER.
Protein: NADK_CHLPM
Sequence: MSLGIVVNVSRQSAIDLARRLARWLDERKVDYVFESLSAEKTGSHRSAPIEELNTQCDAFISLGGDGTLLFTSQHSVTKPVIGVNVGRLGFLAEFSPEEMLPAVERFLNGDYSIHTRSQLEAGLLTNGSPEHFRALNDVVIEKGTYPRIPAFIIKLDGELLSSYRADGIIIATSTGSTAYSMSAGGPIIAPKSSVVVITPICPHMLTVRPIVISDEKSIEVSVDAPDGAFPLNCDGHLRKMLAPQEVVTIKKSSQSINLVANSSRDYCEVLRTKLLWGREA
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGH_PSEPF
Sequence: MKRFVSVVALSGVVSLAGCVAPTPKPNDPYYAPVLPRTPLPSAANNGSIYQAGFEQNLYSDRKAFRVGDIITITLNERTQASKNANSQVAKNSKTGIGLTSLFGGSATTNNPLGGNDLSLDVGYSGDRATKGDSKAAQGNTLTGSITVTVADVLPNGIIAVRGEKWMTLNTGDELVRIAGLVRADDIATDNTVSSTRVADARITYSGTGSFADASQPGWFDRFFLSPLFPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: RLMKL_PSEPF
Sequence: MSDRFELFLTCPKGLEGLLIEEAVGLGLEEAREHTSAVRGMATMETAYRLCLWSRLANRVLLVLKRFPMKNAEDLYHGVLDVDWQDHMLADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRTPQGDRPSIDKLNPDLRIHLRLDRGEAILSLDLSGHSLHQRGYRLQQGAAPLKENLAAAILIRSGWPRIAAEGGALADPMCGVGTFLVEAGMIAADMAPNLRREQWGFTAWLGHVPALWKKLHEEAVERAAAGLAKPPLWIRGYEADPRLIQPGRNNVERAGLSEWIKIYQGEVATFEPRPDQNQKGLVICNPPYGERLGDEASLLYLYQNLGERLRQACLNWEAAVFTGAPDLGKRMGIRSHKQYSFWNGALPCKLLLIKVLPDQFVTGERRTPEQRQAEREQAAYDQTPNEPQERKFNKNGNPIKPTPAPAPVIEQPRLSEGGQMFANRLQKNLKAMSKWVKREGIDCYRVYDADMPEYAMAIDLYHDWVHVQEYAAPKSIDPEKASIRMFDALAAIPQALNIDKSRVVVKRRERQSGTKQYERQAAQGKFNEVTEGGVKLLVNLTDYLDTGLFLDHRPMRMRIQKEAAGKRFLNLFCYTATASVHAAKGGARSTTSVDLSKTYLDWARRNLSLNGFSDKNRLEQGDVMAWLENCREEYDLIFIDPPTFSNSKRMEGIFDVQRDQVQLIDLAMARLASGGVLYFSNNFRKFQLEDNLAERYAVEEITASTIDPDFARNGKIHRAWKITAR
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDH_CHLTA
Sequence: MVSQTVSVAVTGGTGQIAYSFLFSLAHGDVFGLDCGIDLRIYDIPGTERALSGVRMELDDGAFPLLQRVQVTTSLHDAFDGIDAAFLIGSVPRGPGVERRDLLKKNGEIFATQGKALNTTAKRDAKIFVVGNPVNTNCWIAMNHAPRLLRKNFHAMLRLDQNRMHSMLSHRAEVPLSAVSQVVVWGNHSAKQVPDFTQALINDRPIAETIADRDWLENIMVPSVQSRGSAVIEARGKSSAASAARALAEAARSIYQPKEGEWFSSGVCSDHNPYGLPEDLIFGFPCRMLATGEYEVIPRLPWDAFIRGKMQISLDEILQEKASVSL
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: TILS_SYNJB
Sequence: MARLSPLHLRVQCAIRQQQLLHPGQRLLVAFSGGQDSFCLLQILRDLQPRWGWQIFVLHCDHRWSADETECARFLQGWLQQQGLPHAVETADPIRRDEAGARAWRYQQLEKWARTWDCSAVVMGHTASDRAETFLWNLLRGTGAAGLSSLDWQRHLDDRDPTSAQVVRPLLGLYRWETEQFCQQHQLPVWPDRSNQDLAHGRNRLRLEVMPYLKQHFNPQLEAALNRAATLLQAEHELVVAQAAQLWPQVYEPALPGLRRDPLRAAPLALQRQVMFQFLSLVLPHHPTFEQVEAGIQLLKADRGSRSPDYPGGHWLEVKGDHLVCFH
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VANA_PSES9
Sequence: MICNERMVIYRGAGQRVAALEDFCPHRGAPLSLGSIQDGKLVCGYHGLVMDCDGRTASMPAQRVQAFPCIRAFPAQERHGFIWVWPGDAALADPALIPHLEWAENPAWAYGGGLYHIACDYRLMIDNLMDLTHETYVHASSIGQKEIDEAPVSTRVEGDRLITGRFMEGILAPPFWRAALRGNGLADDVPVDRWQICRFTPPSHVLIEVGVAHAGRGGYDAPADCKASSIVVDFITPETDTSIWYFWGMARSFRPEDNELTARIREGQGTIFAEDLEMLEQQQRNLLAWPERPLLKLNIDAGGVQSRRIIERLVSAERAAEAQLIGRQA
What are the official names of this protein?
Vanillate O-demethylase oxygenase subunit, 4-hydroxy-3-methoxybenzoate demethylase.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.
Protein: LEUD_PSYIN
Sequence: MEAYKKHTSIAALMNRSNVDTDQIIPTQFLKKVERTGFGIHLFHDWRFLADNVTPNPEFELNKPVFKGAKILVTGDNFGCGSSREHAPWAIADYGFNTVISTSFADIFYTNCFKNALLPIRVSKDELAALMAEISANEGVKFTVDLEAEKLTTPGGIVIHIEVDPFRKESLLGGLDDIAWTLKHEDKITAFEEKQKQTLPWLWK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: IF2_ACICJ
Sequence: MSDEQDQGETKGRLSLRPVNRGELGRTVDAGSVRQSFSHGRSKVVQVEVRKKRGGAAGAETGRPSAPSRASGGAAAPRGLTAAEQAARQRAVVEQQREAARLEAERREQEKISILSAAEEARRKAEEEARAAEEAERLRAEEEARRREEEEAERRRAAEASQATAAPPAPAAAASPRAAMPAPTAAPARPGAAPARRTAPVPPATSASETLRLRAARTGRDEEEEASRPARRPGSGAAPSRKPSVPAPKKVGDDRRRGARIDVQAALSGDDERVRSLASVRRQRDRERRQAELERLRSDQVRVVREVVLPETITVQELANRMAARVPEVVKSLMKLGVMATATQTIDADTAELVVEEFGHRSKRVSESDVELGLEGQEDSETDLKVRPPVVTIMGHVDHGKTSLLDALRSTDVAAREAGGITQHIGAYQVTLESGAKMTFIDTPGHEAFTAMRARGASVTDIVILVVAADDGVMPQTVEAIRHAKAANVPIIVAINKIDRPDANPNRVRSELLQYDIAVEAMGGETQDVEVSALKRQGLDALQEAILLQAELLDLKANPNRSAEGAVIESSLDRGRGPVATVLVQKGTLRQGDIVVAGTEQGRVRAMLDDHGQPLKDAGPSTPVEILGLSGVPGAGEVFVVVENEGRAREIAEFRQRKLREHAAAAGAAARGTLDQMLARIQAGEQKEVALVIKADVQGSAEAIQATVQKLGNDEVRVRVLLAGVGQITESDVQLAKASDAIIVAFNVRANAQARTLASRDGVDIRYYSIIYQVSDDIETMVKGKLAPIEREKFLGYAEIRQVFNITKVGKVAGCYVTEGLVKRGAGVRLLREGVVIHQGELSQLKRFKDDVREVARGYECGLSFAGFSDLREGDVVECYETETVPA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEEO_ECOLI
Sequence: MLRHILTAKNLLSNPIFKFPNCLPFLSTVCCICRQFVGENLCSFADSPSLFEMWFHFLQLRSALNISSALRQVVHGTRWHAKRKSYKVLFWREITPLAVPIFMENACVLLMGVLSTFLVSWLGKDAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARVATRQSLVIMTLFAVLLATLIHHFGEQIIDFVAGDATTEVKALALTYLELTVLSYPAAAITLIGSGALRGAGNTKIPLLINGSLNILNIIISGILIYGLFSWPGLGFVGAGLGLTISRYIGAVAILWVLAIGFNPALRISLKSYFKPLNFSIIWEVMGIGIPASVESVLFTSGRLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGSALGSASTIITGRRLGVGQIAQAEIQLRHVFWLSTLGLTAIAWLTAPFAGVMASFYTQDPQVKHVVVILIWLNALFMPIWSASWVLPAGFKGARDARYAMWVSMLSMWGCRVVVGYVLGIMLGWGVVGVWMGMFADWAVRAVLFYWRMVTGRWLWKYPRPEPQKCEKKPVVSE
What is the function of this protein?
A transporter able to export peptides and flavins.  When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed:20067529).  Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export (PubMed:20067529).  When overexpressed increases secretion of FMN and FAD but not riboflavin; intracellular concentrations of FMN and riboflavin rise, possibly to compensate for increased secretion (PubMed:25482085).  Increased overexpression causes slight cell elongation (PubMed:25482085).
What are the official names of this protein?
Probable FMN/FAD exporter YeeO.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MATK_PANGI
Sequence: MEEFQRYLELDRSQQHYFLYPLIFQEYIYALAHDHGLNINRSILLENAGYDNKFSLLIVKRLIARMYQQNHLILSTNDSNQNRFLRRNKNLYSQMISEGFAVIVEIPFYLQLKSSLESKGIVKSHNLRSIHSIFPFLEDKISHLIYGLEILIPYPVHLEILVQTLRYWVKDASSLHLLRFFLHEYCNWNTPNKAGSSFSKRNQRLFFLLYNSHLCEYESIFIFLRNQSSHLRSTSSGTLLERIYFYGKIKYLVKVFVKAFQVNLLLLKDPFMHYVRYQGKSILASKGTPFLMKKWTYYFVNLWQCHFYLWSQPGRICINQLYNHSLDILGYLSSARLNPSMVRGQMLENSFLIDNAINKFDAIVPIIPLIGSLAKAKFCNVLGHPISKAVWTDLSDSDIIDQFGRICRNLSHYHSGSSQKKSLYRIKYILRLSCARTLARKHKSTVRAFLKRLGSGLLEEFFTAEEQVLYLTFPRASSASQRLYRRRIWYLDIICINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS17_MESH2
Sequence: MLKMNNLTLEKKAQTRNLRKTLQGIVIRTSPKTIMVEVETAYKHKLYAKRFKKRKKFNTHDEKNLAEVGDFVKIAECRPISKTKHFRLVEVLQKKGEI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: VES_ECO27
Sequence: MEYFDMRKMSVNLWRNAAGETREICTFPPAKRDFYWRASIASIAANGEFSLFPGMERIVTLLEGGEMFLESADRFNHTLKPLQPFAFAADQVVKAKLTAGQMSMDFNIMTRLDVCKAKVRIAERTFTTFGSRGGVVFVINGAWQLGDKLLTTDQGACWFDGRHTLRLLQPQGKLLFSEINWLAGYSPDQVQ
What are the official names of this protein?
Protein Ves.
What is the protein family that this protein belongs to?
Belongs to the Ves family.
Protein: TF2H2_RAT
Sequence: MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDETHYKELLARHVSPPPASSGSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDNNSTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYKGERFCYGCQGELKDQHVYVCTVCRNVFCVDCDVFVHDSLHCCPGCVHKIPTQSGV
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.  The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
What are the official names of this protein?
General transcription factor IIH subunit 2, Basic transcription factor 2 44 kDa subunit, BTF2 p44, General transcription factor IIH polypeptide 2, TFIIH basal transcription factor complex p44 subunit.
What is the protein family that this protein belongs to?
Belongs to the GTF2H2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: QUEA_SYNS3
Sequence: MPDSRDLQLSSYDYVLPEDRIAQAPVEPRHDARLLVVPPAERSLSELRHQRVWDWQQELQPGDLLVVNDTRVLKARLRVRRSGGGLGELLVLEPRGEGRWLCLARPAKRMRPGDQLWLEALEQEPLSLAVLANDAASGGRIVQFPPDCVDALSLEGLLERYGEVPLPPYITRHDSSDQERYQTRYATRPGAVAAPTAGLHLSDALLAAIAERGVALAHVTLHVGLGTFRPVETEDLSDLTLHSEWVEVRAEVVEAVLACRARGGRVIAVGTTSVRALEAAAAGGGGLQPLKGPVDLVIQPGYRFQVVQGLLTNFHLPKSSLLLLVSALIGRDQLLQIYNAAIEEMYRFYSYGDAMWIAPEAVLFDARPE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NVFB_ASPN1
Sequence: MGGKAQNGEDEARGKVLSSLPPSLVPYAELMRVHRPLGYYLNTSPYVVGVVFGAAVAPTKLPATILLDRLLILVLWSLFLRSAGCVWNDVIDMDLDRQIARTRLRPLPRGAVSSWNAVMLTAGIFACGGSLLSFLPRECAIEALIEIFFALLYPFGKRFTDFPQLILVNIGWAIPMSMHSLGLDPLAYKKPTFFMFLFIALVIVMIDVVYSRQDTEEDMKVGVKSMAVRFKHSIELLSYAFFYASTGALLAAGYYSGLGIPFTVLSVGGHFGGFLYFLKTTGVGKAPQVESYAKLACLIASLFWVVGLFVEYYLRV
What is the function of this protein?
DMOA farnesyltransferase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety (PubMed:29968715).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (PubMed:29968715).  DMOA is then converted to farnesyl-DMOA by the farnesyltransferase nvfB (PubMed:29968715).  Epoxydation by FAD-dependent monooxygenase nvfK, followed by a protonation-initiated cyclization catalyzed by the terpene cyclase nvfL leads to the production of asnavolin H (PubMed:29968715).  The short chain dehydrogenase nvfC then as a 3-OH dehydrogenase of asnovolin H to yield chemesin D (PubMed:29968715).  There are two branches to synthesize asnovolin A from chemesin D (PubMed:29968715).  In one branch, chemesin D undergoes Baeyer-Villiger oxidation by nvfH, methylation by nvfJ, and enoyl reduction by the nvfM D enoylreductase that reduces the double bond between C-5'and C-6', to form respectively asnovolin I, asnovolin K, and asnovolin A (PubMed:29968715).  In the other branch, the methylation precedes the Baeyer-Villiger oxidation and the enoyl reduction to yield asnovolin A via the asnovolin J intermediate (PubMed:29968715).  Asnovolin A is further converted to fumigatonoid A by the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfI that catalyzes an endoperoxidation reaction (PubMed:29968715).  The alpha/beta hydrolase nvfD then acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization (PubMed:29968715).  The following step utilizes the ketoreductase nvfG to produce fumigatonoid B (PubMed:29968715).  The dioxygenase nvfE further converts fumigatonoid B into fumigatonoid C (PubMed:29968715).  Finally the Fe(II)/2-oxoglutarate-dependent dioxygenase nvfF catalyzes two rounds of oxidation to transform fumigatonoid C into the end product, novofumigatonin A (PubMed:29968715).
What are the official names of this protein?
DMOA farnesyltransferase nvfB, Novofumigatonin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS5_DEHMC
Sequence: MLAKVERIDPSELELNDKLIFINRVTKVVKGGKRMGFAALVVTGDGKNHVGIGVGKAKEVPSAISKASANAKRNLSRILLNGTTVPHEIVFKYGAAQVLLKPAAPGTGIIAGGSVRAVLESTGIKDVLTKSMGCSNKANVAKATLGGLTAMRDPKATVTKRRSSLKEEATGG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RS7_THEAB
Sequence: MRRRRAEVRKVPPDPIYNDVLVSKLINRVMWDGKKSIAQKIVYKAMEYLSEKTKKDPLEALHQAIDNVRPLVEVRPRRVGGATYQVPIEVEEPRKTSLALRWIVEAARSKKGRPMAEKLGEELVNAFNNTGTAIKKKEDVHRMAEANRAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RS16_MYCGI
Sequence: MAVKIKLARFGKIRNPQYRISVADARNRRDGRAIEVIGRYHPKEDPSIIEIDSERAQYWLGVGAQPTEPVLQLLKITGDWQKFKGLPGAEGTLKHKEPKPSKLDLFNAALAEAEGGPSTEATTPKKKKAPAKKDEQPTEKAAEPAAEKAAEPAAEAPAEAAAESEAPAAE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RECX_JANMA
Sequence: MAKLQVSLKARALRYLSAREHSRQELGRKLARHAQEGDDVEALLDTLEAAKFLSQSRFSESLVHRRAARFGNSRILSELKSHGIDPDSLTDIKANLESDEFARARAVWERKFGTVATNQEERAKQMRFLMQRGFSHRAIQAAMRAAGKDED
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.