PharMolix/UniProtQA huggingface dataset:
Protein: PELO3_PELFU
Sequence: MFTLKKSLLLVFFLGTISLSLCEDERNADEDDGEMTEEVRRGLMDSLKGLAATAGKTVLQGLLKTASCKLEKTC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Pelophylaxin-3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MST12_MAGOR
Sequence: MYSHPHNAGVAAAPQKPETFMLSTEAQQALPHDAQVALQQVDNLKYFLISAPVDWQPDQYIRRFLLPTGEYVSCVLWNNLFHISGTDIVRCLSFRFQAFGRPVKNSKKFEEGIFSDLRNLKSGTDASLEEPKSPFLDFLYKNNCIRTQKKQKVFYWYSVPHDRLFLDALERDLKREKMGQEATTMAVSEPALSFQYDSSQSLYEQLTKAQQANSSSFNAQQVSFPPSQSTSPVMRAMDSMPPPPQMMPQPMPQSMAPLADGLDAMVPYAAMGMAPGMPPQPAVKREPDFNRVQYNQNGVPINQGHQRHASMPAYGLEYSPAPSFVSSHYDDYGNRGISFEPLTPPQQAMGMGAEPAYIANEETGLYTAIPDHMNGVNGLNGMIQLPPSNLAGPQFTRSYGSNNVYSVIEGSPTYKQRRRRSSIPPGMSAIAAATAAATAAHRPSDLRRSVSASVGPVAEGDESLDNSPPGLIYSNQPMSMANHQREAMEQMSRHGTPLSTVEGSPGMHNVNLEQQQYPMPSEDMTSPMDDRSRPMAQGGPSVVRRARSATVMGSEVGPYPQKSHSCPIPTCGRLFKRLEHLKRHVRTHTQERPYICPYCSKAFSRSDNLAQHKRTHDRADGGEGLILSGEDEEEYSGDDHLGSLEEASPTSEGGYVTSSLNSAMAHSNTSQHPGSNAVSPNPGPMSHAPTYNSMQTLMQPMQMSQPQPINAGGMM
What is the function of this protein?
Transcription factor that may function downstream of PMK1 to regulate genes involved in infectious hyphae growth (PubMed:11952120).  Is not essential for vegetative growth, conidiation or appressorium formation (PubMed:11952120).  May be involved in the regulation of the expression of the cell surface sensor MSB2 (PubMed:21283781).
What are the official names of this protein?
Transcription factor MST12.
What is the protein family that this protein belongs to?
Belongs to the STE12 transcription factor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURG_BURCJ
Sequence: MTASQRTLMVMAGGTGGHVFPGLAVAHRMEAAGWRVVWLGNPAGMEATLVPKHGIPMEYVRFGGLRGKGLKTKLTLPVNLLRACWQSLGALRRVRPDVVLGMGGYITFPAGVMTALSGRPLVLHEQNSIAGLTNKVLAKLAKRVLVAFPGALPHAEWTGNPIRAELAHTEPPQARYASRGGPLNVLVVGGSLGAAALNEVVPRALALLAPGERPRVVHQAGVKHIEALKANYEAAGFAAGEDVRLVPFIDDMAAAYAAADLVICRSGAMTVSEIAAVGVAALFVPFPHAVDDHQTTNAAFLADAGAAVLVQQRDLSAELLADWLRGQSRASLADMAERSRSLAKPEATDEVARVCAKAAGANLEQLQ
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: APOA2_PHOVI
Sequence: MKLLALAVLLLAVCSLEGAFVRRQAEEPNLQSLVAQYFQTMTDYGKDLLEKAKGPELQAQAKAYFEKTQEQLTPLVKKAGTDLINFLSNFMDLRTQPATQ
What is the function of this protein?
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
What are the official names of this protein?
Apolipoprotein A-II, Apo-AII, ApoA-II, Apolipoprotein A2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FADA_SHIBS
Sequence: MEQVVIVDAIRTPMGRSKGGAFRNVRAEDLSAHLMRSLLARNPALEAAALDDIYWGCVQQTLEQGFNIARNAALLAEVPHSVPAVTVNRLCGSSMQALHDAARMIMTGDAQACLVGGVEHMGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARMHGISREMQDAFAARSHARAWAATQSGAFKNEIIPTGGHDADGVLKQFNYDEVIRPETTVEALATLRPAFDPVNGTVTAGTSSALSDGAAAMLVMSESRAHELGLKPRARVRSMAVVGCNPSIMGYGPVPASKLALKKAGLSASDIGVFEMNEAFAAQILPCIKDLGLMEQIDEKINLNGGAIALGHPLGCSGARISTTLLNLMERKDVQFGLATMCIGLGQGIATVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_AERPE
Sequence: MSLVGQMYKREKPIPEWKTLMLRELEELFSKHRVVLFADLTGTPTFVVQRVRKKLWKKYPMMVAKKRIILRAMKAAGLELDDNLLDDLVRGQMLLVFADGNPFKIVKEVEKEKVAMPVKPGDKAETEIRIPEGMTNLTPGPILSVFGKLRIQYQVRGGKIYIAKETVVAKPGDVISEDLAGLLMALGIRPIEKGVRVKFAIDGGVLITEDLLRPDIEAFRGDVIDAAKEALGLATEIVYMPVPEAVESAIVKAALAASALAAETGFIAPGTVEDVVRKAIAEEAAVVALLGDKARELGIEEAAPAAAPAAEEKAEEEKKEEEEEKKEDQELSGLDSIFGGF
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10, Acidic ribosomal protein P0 homolog.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: TAT_SIVEK
Sequence: MEPVDPELEPWNHPGSQPKTACNNCHCKVCCYHCVYCFTKKGLGISYGRKKRSQRRRTPQSNKSHQDPLPKQPLSQRLGDQTGQKEQKKTLES
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: RL21_LEPIC
Sequence: MYAIISVGNRQYKVTQDQEFLTEKTGKNAGESFDAKVLLFAESNNKVHIGQPELKTARVSLKVLEDVKGDKIHGYVYKRRKNYQKAWGHRQQLQKVKVVSLSAV
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: NRG4_HUMAN
Sequence: MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH
What is the function of this protein?
Low affinity ligand for the ERBB4 tyrosine kinase receptor.  Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.  Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
What are the official names of this protein?
Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4.
What is the protein family that this protein belongs to?
Belongs to the neuregulin family.
What are the subcellular locations of this protein?
[Pro-neuregulin-4, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. SUBCELLULAR LOCATION: [Neuregulin-4]: Secreted.
Protein: TRMFO_THET2
Sequence: MERVNVVGAGLAGSEAAWTLLRLGVPVRLFEMRPKRMTPAHGTDRFAEIVCSNSLGGEGETNAKGLLQAEMRRAGSLVMEAADLARVPAGGALAVDREEFSGYITERLRGHPLLEVVREEVREIPPGITVLATGPLTSEALAEALKRRFGDHFLAYYDAASPIVLYESIDLTKCFRAGRYGQSADYLNCPMTEEEYRRFHQALLEAQRHTPHDWEKLEFFEACVPVEELARRGYQTLLFGPMKPVGLVDPRTGKEPFAVVQLRQEDKAGRMWSLVGFQTGLKWPEQKRLIQMIPGLENAEIVRYGVMHRNTYLNAPRLLGETLEFREAEGLYAAGVLAGVEGYLESAATGFLAGLNAARRALGLPPVAPPEESMLGGLVRYLATANPEGFQPMYANWGLVPPVEGRMGKKEKRQAMYRRGLEAFSAWLSGLNPPLPRPEAALV
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_META1
Sequence: MYNINDLIYNWSFALFDLANDEGILKELTADVVKVIKVLKRNKRYLEILNSYNVDLDVKFQKIDEAFSGNNIHLINFIKLAAKAAVAKFLIQILVRFVEISNQKLNVKYGTIFTTIALDEVKVKEFESKISKKLNAKVILKNEIDPSLIAGIKIKIDDYVVENSISGYLNELKKSVIKK
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CH10_BORPA
Sequence: MALRPLHDRVIVKRLDNERKTASGIVIPDSAAEKPDQGEVVAVGPGKKTEDGKILPVDLKAGDKVLFGKYAGQTVKVDGEELLVIREDEILAVIQ
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNAA_ECO24
Sequence: MENFKHLPEPFRIRVIEPVKRTTRAYREEAIIKSGMNPFLLDSEDVFIDLLTDSGTGAVTQSMQAAMMRGDEAYSGSRSYYALAESVKNIFGYQYTIPTHQGRGAEQIYIPVLIKKREQEKGLDRSKMVAFSNYFFDTTQGHSQINGCTVRNVYIKEAFDTGVRYDFKGNFDLEGLERGIEEVGPNNVPYIVATITSNSAGGQPVSLANLKAMYSIAKKYDIPVVMDSARFAENAYFIKQREAEYKDWTIEQITRETYKYADMLAMSAKKDAMVPMGGLLCMKDDSFFDVYTECRTLCVVQEGFPTYGGLEGGAMERLAVGLYDGMNLDWLAYRIAQVQYLVDGLEEIGVVCQQAGGHAAFVDAGKLLPHIPADQFPAQALACELYKVAGIRAVEIGSFLLGRDPKTGKQLPCPAELLRLTIPRATYTQTHMDFIIEAFKHVKENAANIKGLTFTYEPKVLRHFTAKLKEV
What are the official names of this protein?
Tryptophanase, L-tryptophan indole-lyase, TNase.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: RR3_LOBMA
Sequence: MGQKINPLGFRLGTTQSHRSLWFAQPKKYSEGLEEDKKIRDCIKNYVQKNIRISSGMEGIARIEIQKRIDLIQIIIYMGFPKLLIEDKPRRVEELQMTVQKELNCVNRKLNIAITRISNPYGHPNILAEFIAGQLKNRVSFRKAMKKAIELTEQANTKGIQVQIAGRIDGKEIARVEWIREGRVPLQTIEAKIDYCSYTVRTIYGVLGIKIWIFVDEE
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NDHN_ACAM1
Sequence: MPLLATGKKFIRTIEQSGAVGIYVPSEGGFEGRYKRRLRATGYLTLFVSAPGMGDLASYFTDVHGVRPPHLGKNQIRTYFLPPFVTYQLENLPPQAKGLALWLYDGKRLAKQELAYLSAITASEPRLKVVVELGGARSFEWQPLSDIVAAA
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit N, NAD(P)H dehydrogenase I subunit N, NDH-1 subunit N, NDH-N.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhN subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GHRA_ECOL6
Sequence: MDIIFYHPTFDTQWWIEALRKAIPQARVRAWKSGDNDSADYALVWHPPVEMLAGRDLKAVFALGAGVDSILSKLQAHPEMLKPSVPLFRLEDTGMGEQMQEYAVSQVLHWFRRFDDYRIQQNSSHWQPLPEYHREDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVLINLLPNTPETVGIINQQLIEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFNREPLPPESLLWQHPRVTITPHVAAITRPAEAVEYISRTIAQLEKGERLCGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIS_PSESP
Sequence: MFPRLPTLALGALLLASTPLLAAQPVTTLTVLSSGGIMGTIREVAPAYEKATGVKLDIAAAPSMGDTPQAIPNRLARNEPADVVLMVGSALDKLVASGQVAKDSRVDLGQSFIAMAVRQGAPKPDISNMDAFKQTLEKAQSVAYSDSASGVYLSRILFPRMQLDKSFMAKARMIPAEPVGAVVARGEAQLGFQQLSELKAVPGIDIVGLIPDQAQKMTLYSGAMVSKSQHPEAARALLQYLASKDAAKAIEDSGLKPVPAQP
What is the function of this protein?
Involved in assimilation of trans-aconitic acid.  Preference for cis-aconitic acid is 14-fold higher than for trans-aconitic acid.  Not active on intermediates of tricarboxylic acid (TCA) cycle including citric acid, succinic acid, fumaric acid, and 2-oxoglutaric acid or on other dicarboxilic acids including itaconic acid, formic acid, citraconic acid or maleic acid.
What are the official names of this protein?
Aconitate isomerase, AI.
Protein: FB217_ARATH
Sequence: MLPSPSVHMASPPPSLNMASHPPSPATASRKRFQDSSKKIMNPSFADLPSSLIEEIMLLLVLKDNIRASAACKSWYEAGVSVRVVDKHPWLMCFPKRGNLFEFRDPLHWKLHTLDLPELAESTVCYSRFGWLLMRKASSNDVFFFNPFSRDIISLPMCELDFQQIAFSCPPTSDDCVLLAIKFVPGEVNRVTVSTCNPGATKWITNDFPTFLRLFYMQSNLVYRRDRFYCFNAEGTLYSFEPSYREWSYICADKLRCPYVHENQYMWCGKAVFLVEKKGELFVMFTCSNEKPMVYKLFSMKWKELSRTTLDGMTFFVSFYNSELRNNLPWMRNNVYFSRFGYNRKHCVSFSFDESRYNTPKEWEQWVELCPPQSLWIDTPKNVLDYFL
What are the official names of this protein?
F-box protein At4g00893.
Protein: ASSY_LEGPC
Sequence: MKKVIKKIALAYSGGLDTSIMIPWLKEHYEHAEVIAVICDLGQQEDLDTIKNKALKSGASKAYVVDVKNEFAIQYLWPLVKSGALYEDQYILGTISRPLIAQKLVEIALTEQVNAVAHGATGKGNDQVRFEYSIKALAPQLEIIAPWRTWDIKSRQEAIVYAKAHGIEVPVTPKAPYSRDHNIWYISHEGGVLEDPSQEMPDDVLLMTAPVSQTPDEEEVVVLDFKKGVPVALNGQELSPVDLLNSLNQKAGQHGIGVADIVENRLVGMKIRGIYEAPAAAVLYKAHKLLESLCLTRSTLHLKQSLQQTYANLVYEGRWFSQTKQALDAFIDVTQQHVTGCVKLKLFKGNIIPAGMHSPYSLHHPELATFEEDNVYNQKDAEGFINLFSLSAKIYSQVHQEGNYD
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_HYPNA
Sequence: MADSAHVPETLAGGFFSVGLAERDPELAAAINQEATRQQHQIELIASENIVSRAVLEAQGSILTNKYAEGYPGKRYYGGCEFVDIAEELAIERAKKLFNCGFANVQPNSGSQANQGVFQAVLKPGDTILGMSLAAGGHLTHGAKPNQSGKWFNAVQYGVRPEDHLIDFDEVERLARAHRPQMIIAGGSAYPRQIDFKRFREIADDVGAIFLVDMAHFAGLVAGGAHPNPLDHCHIATTTTHKTLRGPRGGMILTNDEALAKKINSAIFPGIQGGPLMHVIAGKAVAFGEALMPEFKTYVEQVVSNARAMAAACRTAGLDVVSDGTDTHLALIDLRPKGVTGRDAEAALERAYITCNKNGIPFDPAPPTVTSGIRVGSPAGTTRGFREEEFIQIGTWIGEIVDALANGNSDAVEARVREEVKALTARFPIYEGLGG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBC9_PAGMA
Sequence: MSGIALSRLAQERKAWRKDHPLGLVAVPTKNPDGTMNLMNGECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIFCQDRTEYEKRVRAQAKKFSPS
What is the function of this protein?
Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4.  Essential for nuclear architecture and chromosome segregation.
What are the official names of this protein?
SUMO-conjugating enzyme UBC9, RING-type E3 SUMO transferase UBC9, SUMO-protein ligase, Ubiquitin carrier protein I, Ubiquitin-conjugating enzyme E2 I, Ubiquitin-protein ligase I.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KS6B_CAEEL
Sequence: MADVFEFELEGHESQASPQRHAYHYDNCTEIMEDDHMYSNVADGQISAPPPSSSYMEDPMMESIQLCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTTGSDNGQIFAMKVLQKATIVRNQKDTAHTKAERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEIVVSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQKTHTFCGTIEYMAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRLTLPAYLSNEARDLIKKLLKRHVDTRLGAGLSDAEEIKSHAFFKTTDWNLVYARQLEAPFKPNIENDEDTSLFDARFTKMTPVDSPCETNFSLNGDNPFVGFTYVAPSVLEMMNKGGHGGISVAHLASSMSRAGAAKSPRKPGDPETASILHGGHSNLFGHGPNSEAPQAFGYGIGSQMTTTTAGGAGIQQPYQSFSGGYPEDDAMDTSTPRASESRETTTGNGSTTTTRPSNVGSSASTPIPLPKRVM
What is the function of this protein?
Serine/threonine-protein kinase which regulates mRNA translation (PubMed:17266680).  Negatively regulates lifespan and resistance to starvation, oxidative stress, protein aggregation and P. aeruginosa-mediated infection (PubMed:17266680, PubMed:23879233, PubMed:24332851).  May regulate these processes by preventing the activation of transcription factor hif-1 (PubMed:23879233).  Required, probably downstream of let-363/TOR, for the establishment of the proper number of germline progenitors by promoting cell cycle progression and preventing differentiation during larval development.  Regulates germ cell size (PubMed:22278922).  In addition required for sperm production and embryo viability (PubMed:17266680, PubMed:22278922).  Involved in axon regeneration of PLM and ALM neurons by inhibiting growth cone formation early after axotomy and later by inhibiting axon extension.  Functions in axon regeneration and lifespan probably by preventing aak-2/AMPK activation (PubMed:24332851, PubMed:24431434).  Negatively regulates autophagy (PubMed:22560223).
What are the official names of this protein?
Ribosomal protein S6 kinase beta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
What are the subcellular locations of this protein?
Cell projection, axon. Perikaryon. Note=Enriched in the synaptic branch of PLM neurons.
Protein: DRC3_MOUSE
Sequence: MSRPYDSMEPKVMDDDMLKAAVGEQGPQEEAGQLAKQEGILFKDVLSLQLDFQNILRIDNLWQFENLKKLQLNNNIIERIEGLTNLIHLVWLDLSFNNIEAIEGLDTLVNLEDLSLSNNRISKVDSLDALVKLQVLSLGNNQISNMMNIIYLRRFPCLRTLSLAGNPVSEAEEYKMFIYAYLSDLVYLDFRRVDEQMREMAKMKHQYSIDELKHREAQLQMKLEEEQAKQEKLEEHKMAFVEHLNGPFLFDSMYSEDVEGNKLSYLPGVRELLEAYKDKFVIICLNIFEYGLNQQEKRKVELDTFNECIQEAILENQDQGKLKVAKFEEKHLLNLNAIREETDLSNIEKKLTECTESIGELFNTLMILEMQLVEQLEETINIFERNITDLVGLFIENVQSLIAQCRDLENHHHEKLLEIAINTLEKILKGEMDEDLPDDVRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTGINSWCAHLVDKIHKDEIMRNRKRVKEINQFVDHMQSELDNLECGDIID
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
What are the official names of this protein?
Dynein regulatory complex subunit 3, Leucine-rich repeat-containing protein 48.
What is the protein family that this protein belongs to?
Belongs to the DRC3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme. Cell projection, cilium, flagellum.
Protein: RN138_MOUSE
Sequence: MSEELSAATSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFLTAMRESGIHCPLCRGSVTRRERACPERALDLENIMRRFSGSCRCCSKKIKFYRMRHHYKSCKKYQDEYGVSSVIPNFKISQDSVRSSNRSETSASDNTETYQEDTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNM
What is the function of this protein?
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination.  Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination.  Two different, non-exclusive, mechanisms have been proposed.  According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination.  According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP.  Together with NLK, involved in the ubiquitination and degradation of TCF/LEF.  Also exhibits auto-ubiquitination activity in combination with UBE2K.  May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF138, RING finger protein 138, RING-type E3 ubiquitin transferase RNF138.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers.