PharMolix/UniProtQA huggingface dataset:
Protein: LGT_FRACC
Sequence: MVLAAIPSPSRGVVHLGPVPLRAYALMIIIGVFVAVFVTGRRLRARGMDPMVASEVAYWAVPFGIVGARVYHVVSTPAAYFGRDGNVLDVIKIWNGGLGIWGAIAGGAFGAWLATRRYGISLALFGDAAAPGIILAQAIGRWGNWFNQELYGKASTLPWAVRIDEKHQIIPGVSTYQPTFLYECLWNLVVAGILLVVDRRHRLGRGKLFCLYVALYTFGRLWIEMLRIDTANQILGLRVNIWTSIVVCLGALLALAVTRSPVDPNLSREEQEALGIARSRPAARSTVTTAGTADQRAAAPDSAGPDSAALDSVGPDSVDPDLGGPDPADPGSAGSVPAAAVPDASGSTATTATTATTATTATTATTATTATTATTGVPAGSQQSRGLATRLPASGGHTSAVPPEEPQLP
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNH2_STRPQ
Sequence: MPTSIKAIKESLEAVTSLLDPLFQELATDTRSGVQKALKSRQKAIQADLAEEERLEAMLSYEKALYKEGYQAIAGIDEVGRGPLAGPVVAACVILPQHCKIKGLNDSKKIPKAKHETIYQAVKEKALAIGIGIIDNQLIDEVNIYEATKLAMLEAIKQLEGQLTQPDYLLIDAMTLDIAISQQSILKGDANSLSIAAASIVAKVTRDQMMANYDRIFPGYGFAKNAGYGTKEHLQELKAYGITPIHRKSFEPVKSMCCDSTNP
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTCA_LACLA
Sequence: MTDKYENPTSDDYMGVVMGIIMSGGNAKGLAFQAIQQAKAGEFAEAESSLNEASEQLREAHDVQTDLLTRLAQGEKIGWNLYMVHAQDHLMNAITFKDLAVEVVGQEQRLQALENK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity).  Involved in cellobiose transport with PtcB and CelB.  This system can also transport lactose (PubMed:17909747, PubMed:21262549).
What are the official names of this protein?
PTS system cellobiose-specific EIIA component.
Protein: TRPF_LEPIC
Sequence: MITNSLQKTKVKICGIKDLEIAKICKEEGADYIGFNFVSSSPRKIELSNAQKIVEYYKSEKNSPEIVLLFYQNSFEEIESITSVLDHDLVQWVWDDPLINRKKLLYKRQICSYRVQTQIHDQDLKDIEAEFLILDSYSKGVGGGTGETFNWELISKVKRKFLLAGGLDPSNVVNAIEIVKPFGVDVASGVESSPGIKDPQKVIQFIRNVKSTS
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: EFTU1_YERE8
Sequence: MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGNARAFDQIDNAPEEKARGITINTSHVEYDTPSRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRDLLSTYDFPGDDTPVVRGSALKALEGEPEWEAKIIELAGYLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGLKDTVKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREDIERGQVLAKPGSIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIQMIVNLIAPIAMDDGLRFAIREGGRTVGAGVVAKVIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 1, EF-Tu 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FH6_ORYSJ
Sequence: MALFRKFFYRKPPDGLLEITERVYVFDSCFTTDVFNDDKYQDYIGDIVAQLQCHFADASFMVFNFREGESQSLLANILSSYEMVVMDYPRQYEGCPLVTIEMIHHFLRSGESWLSLSQQNVLIMHCERGGWAVLAFMLAGLLLYRKQYIGEQRTLEMIYRQAPRELIQLLSPLNPIPSQIRYLHYISRRNVSAVWPPGDRALTLDCVILRNIPGFNGEGGCRPIFRIYGKDPLLATSNTPKVLFSTPKRSKYVRLYKKVDCELIKIDIHCHIQGDVVLECISLDADQQREEMIFRVMFNTAFIRSNILMLNRDEIDILWDAKDRFPKEFRAEVLFSEMDSVNQLDSMEVGGIGEKEGLPVEAFAKVQEMFSNVDWLDPTADAAALLFQQLTSSENIQLRKGLLSPNKKDFHLSSISPTKKQSDNVEDKLSNAELSTIYVHKQENNDVQGLIPQKQATIPDEKSGSSVIHEKMISLVHEEITQVVDINTGCLSSLDMTVPSTMNSSRPVLIDQNSKLDDQFGSLQSSSPTMIMSQQFPVSRSSSVLSSDFSPRLLSACPRFHSAPSALGITALLEDHAAFGDTKNSVKVSSAVVKIPSKQSSQQHPITVTPVVTKCTPSPPPLLPPLAPVVPVPSDDQMISQEKDMSQQAQKHPDLSSFPSLSPTQQKQSTSKLCQTILPTNHQLSSSNITKEPLQISPAPTPPPLPTPSTSSSSSCHCLPPDSMLSTTTALFRPPAPPPPPLQSPSTPRCSPVRTLASPPPPPAPTSSPVRMSGPPPPPPPPAPNSCPSRPAPPPPPPPPLASTSSPPRPAAPSPCQLHTSTSSPARPVPPPPPTLSTIRSSAPTPPLLPGATSAPSPPPPPPPCSSSNQLSAPPPPPPSFSKNNGSIAPPPAPPGGNAKLPGMRGRGPAPPSGPMSRSLQSGQAASRRSNLKPLHWVKVTRAMQGSLWEESQKTDEASKPPVFDMSELEHLFSAVLPSSDGKRSDKSGSRASGSKPEKIHLIDLRRANNCGIMLTKVKMPLPDLMSAILTLDDTILDADQVENLIKFTPTKEEAELLKGYKGDKQVLGECEQFFMELMKLPRVDSKLRVFLFKIQFPSQVSDLKRSLNIVNSSAEEIRGSAKLKRIMQTILSLGNALNQGTARGSAVGFRLDSLLKLSDTRARNNKMTLMHYLSKVLSEKLPELLDFPKDLASLELAAKVQLKSLAEEMQAINKGLEKVEQELTTSENDGPVSEIFRKTLKDFLSGAEAEVRSLTSLYSNVGRNADALALYFGEDPARCPFEQVVITLQNFVRLFVRSHDENCKQLDLEKKKALKEAEAEKTKKEPENAQKTKEPGNDKAKHNNSIKELDISLQSPAQTASAK
What are the official names of this protein?
Formin-like protein 6, OsFH6.
What is the protein family that this protein belongs to?
Belongs to the formin-like family. Class-II subfamily.
Protein: IPO5_HUMAN
Sequence: MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA
What is the function of this protein?
Functions in nuclear protein import as nuclear transport receptor.  Serves as receptor for nuclear localization signals (NLS) in cargo substrates.  Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.  At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.  The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).  Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:9687515, PubMed:11682607).  In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.  Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity).  In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
What are the official names of this protein?
Importin-5, Imp5, Importin subunit beta-3, Karyopherin beta-3, Ran-binding protein 5, RanBP5.
What is the protein family that this protein belongs to?
Belongs to the importin beta family. Importin beta-3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.
Protein: OTU8_ARATH
Sequence: MMKSDGNCQFRALADQLYQNSDCHELVRQEIVKQNMSLSTNSQWGDEVTLRVAADVYQVKIILITSIKLIPFMEFLPKSQKEPDKVIHMSYLAGIHFNSIYKKNKEKGSRSSSSSSSAVWMKLQRKKENEAKKKEEEEKERKDMEKEEKKKDKEDKKKDKEDKKKAKVQKEKKEKKEKKNRNHHFHYSE
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
What are the official names of this protein?
Putative OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 8, OTU domain-containing protein 8, Deubiquitinating enzyme OTU8.
What is the protein family that this protein belongs to?
Belongs to the peptidase C85 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DM7A_DROSE
Sequence: MLRMDTVHRDKGQVVILKKTNYLPYLVNLFIPKLFYPEKIVVARLYINVNKHDKHAAENFKGTETPCFDVPPSLFSDKVPMDKIVFLPTVMLPMGFEAGGVFGPGVLTRRSYPIDLKAAGHKGQTPPLFVGLRMDIQAPTRVKSLLKEVRESQPAQDILMNWVRASNNLINGEQPKEQELRDEFSLSMVFNLPTPPSPPSPYPYGRIPLQFNIYTPDLSNVLLLMSHQRDLTVAILSTVNNPHVPSVAFAAMGDEEECPKFELPLSAFPTFEGVNRPMFLPKRFMPKGFEAGCVLKPGALSDRWFMDNIGRFGPTQPQHNGSITPPLFVGKICREEPTVDMIRNIQLEIEKKASEDATLPAVKPKIDISITKGFMVMETAAEDPKPPKGAYSVQSYEEAFDDGCVVKVAKKVATEATDTRGRDEIRTSCDQPQEKDEGSAEADKKHLSCFHVDSDIDNIAMAMARMGVADISLPAEGEAMPGIDGDRALIQLSHVLEDRNQIRSHTDQLMQDHIFRMNRNRMLALRQPFTCIGCGTQENK
What are the official names of this protein?
DM7 family protein GM11956.
What is the protein family that this protein belongs to?
Belongs to the DM7 family.
Protein: UPPP_BACFN
Sequence: MEWFEALILGLIQGLTEYLPVSSSGHLAIGSALFGIEGEENLAFTIVVHVATVFSTLVILWKEIDWIFRGLFKFEMNSETRYVINILISMIPIGIVGVFFKDEVEAIFGSGLLIVGCMLLLTAALLSFSYYAKPRQKENISMKDAFIIGLAQACAVLPGLSRSGSTIATGLLLGDNKAKLAQFSFLMVIPPILGEALLDGMKMIKGEAIAGDIPTLSLIVGFIAAFVSGCLACKWMINIVKKGKLIYFAIYCAIVGVVTIVVSQLQ
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCST_STAAN
Sequence: MSSDLKQTPLYQNYVDRGAKIVEFGGWAMPVQFSSIKEEHNAVRYEIGLFDVSHMGEIEVTGKDASQFVQYLLSNDTDNLTTSKALYTALCNEEGGIIDDLVIYKLADDNYLLVVNAANTEKDFNWILKHKEKFDVEVQNVSNQYGQLAIQGPKARDLINQLVDEDVTEMKMFEFKQGVKLFGANVILSQSGYTGEDGFEIYCNIDDTEKIWDGLLEYNVMPCGLGARDTLRLEAGLPLHGQDLTESITPYEGGIAFASKPLIDADFIGKSVLKDQKENGAPRRTVGLELLEKGIARTGYEVMDLDGNIIGEVTSGTQSPSSGKSIALAMIKRDEFEMGRELLVQVRKRQLKAKIVKKNQIDK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: PRMA_SHIB3
Sequence: MPWIQLKLNTTGANAEDLSDALMEAGAVSITFQDTHDTPVFEPLPGETRLWGDTDVIGLFDAETDMNDVVAILENHPLLGAGFAHKIEQLEDKDWEREWMDNFHPMRFGERLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTSLCLQWLDSLDLTGKTVIDFGCGSGILAIAALKLGAAKAIGIDIDPQAIQASRDNAERNGVSDRLELYLPKDQPEEMKADVVVANILAGPLRELAPLISVLPVSGGLLGLSGILASQAESVCEAYADSFALDPVVEKEEWCRITGRKN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR9_SCHPO
Sequence: MYALLSVYDKTGLLELAKALTSKGVKLLGSGGTAKMIRESGMEVADVSSITNAPEILGGRVKTLHPAVHGGILARDIPSDEKDLVEQSIEKIDIVVCNLYPFRETIAKPNVTIPEAVEEIDIGGVTLLRAAAKNHARVTILSDPADYATFTDKFLSDKLTQDDRNTYALKAFASTASYDAAITDYFRKQYAAGVDQLTLRYGANPHQSPAQAFMEQGPLPFKVLCGSPGYINLMDALNSWPLVKELRENIGIPAAASFKHVSPAGAAVGLPLSDVEKKVYFVSDITEFTPLACAYARARGADRMSSFGDFIALSDTVDVCTARIISREVSDGVIAPGYEPEALELLKKKKGGKYCVLQMDPKYVPAEIETRQVYGISLQQHRNHAKIDFSLFEKVVSKNKDLPKSALIDLVIATTALKYTQSNSVCYAKNGMVVGLGAGQQSRIHCNRLAGDKADNWWLRHHPKVLGMQFKKSAKRPEKSNAIDLYVLDAVPAEGSEREQWESAFETIPEPLTKKEREEFLATCKDVVCASDAFFPFPDNIYRLAQSGVKYVAAPGGSVMDQAVRDTANEFNMVFSEIPLRLFHH
What is the function of this protein?
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis.  Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR).  Also catalyzes the cyclization of FAICAR to IMP.
What are the official names of this protein?
Bifunctional purine biosynthesis protein ade10.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: Y1918_LISMF
Sequence: MKSIAVTGYKNFELGIFKKDADEAVYIKETIKRHLLPLVEDGLEWVIISGQLGIELWAGDVVAELKADYPIKLAILEPFEKQSANWNEANQLWASEVLEKADYHAFITKRPYESPAQFAARDGFIIDNTDGALLVYDLEKEGSPKFFYDRAIQAKEQSNYYIDCIDFYALQEVVEDMNQTF
What are the official names of this protein?
UPF0398 protein LMOf2365_1918.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: PSBB_SOLTU
Sequence: MGLPWYRVHTVVLNDPGRLLSVHIMHTALVAGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITNSWGGWSITGGTVTNPGIWSYEGVAGAHIVFSGLCFLAAIWHWVYWDLEIFCDERTGKPSLDLPKIFGIHLFLSGVACFGFGAFHVTGLYGPGIWVSDPYGLTGKVQPVNPAWGVEGFDPFVPGGIASHHIAAGTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSSSIAAVFFAAFVVAGTMWYGSATTPIELFGPTRYQWDQGYFQQEIYRRVSAGLAENQSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGSMDNGDGIAVGWLGHPIFRDKEGRELFVRRMPTFFETFPVVLVDGDGIVRADVPFRRAESKYSVEQVGVTVEFYGGELNGVSYSDPATVKKYARRAQLGEIFELDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDVFAGIDPDLDAQVEFGAFQKLGDPTTKRQAA
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: S38A9_RAT
Sequence: MANVDSDSRHLISEVEHEVNPGPMNIQFDSSDLRSKRPFYIEPTNIVNVNDVIQKVSDHAAAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLKSYTEGYRKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIVLMGLLTLYCCYRVVKSRSMIVTSDTTTWEYPDVCKHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTVLSTNNSSPVICPSAGSGHPDNSSMIFYNSDTEVRLFERWWDKSKTVPFYLIGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFIVTLKAIRLGFHLEFHWFAPTEFFVPEIRAQFPQLTGVLTLAFFIHNCIITLLKNNKNQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLPKDCIEQNFLDNFPSSDTLSFIARICLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGVTMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYILSQHQEERLTWPKLVFHIIIIILGLANLIAQFFM
What is the function of this protein?
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels.  Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids.  Acts as an arginine sensor.  Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation.  However, the transport mechanism is not well defined and the role of sodium is not clear.  Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC.  Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases.  Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency.
What are the official names of this protein?
Neutral amino acid transporter 9, Solute carrier family 38 member 9.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
What are the subcellular locations of this protein?
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Protein: STPAP_MOUSE
Sequence: MAAVDSDVVSLPRGRFRCCLCDVTTANRPSLDAHLKGRKHRDLVQLRATRKAQGLRSVFVSGFPRDVGSAQLSEYFQTFGPVANIVMDKDKGVFAIVEMGDISAREAVLSQPKHSLGGHGLRVRPREQKEFQSPASKSPKGVDSSSHQLVQALAEAADVGAQMVKLVELRELSEAERQLRNLVVALMQEVFTEFFPGCVVHPFGSTVNSFDVHGCDLDLFLDMGDMEETEPDPKAPKVPETSSLDSALASSLDPQALACTPASPLDSLSPTSVQESESLDFDTPSSLAPQTPDSALGSDTVTSPQSLPPVSPLQEDRKEGKQGKELELAEEASKDEKEEAAAVLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALYNSRFLNLCSEMDGRVRPLVYTLRCWAQHNGLSGGGPLLNNYALTLLVIYFLQTRDPPVLPTVAQLTQRAGEGEQVEVDGWDCSFPKDASRLEPSTNVEPLSSLLAQFFSCVSCLDLSGSLLSLREGRPLMVAEGLPSDLWEGLRLGPMNLQDPFDLSHNVAANVTGRVAKRLQSCCGAAASYCRSLQYQQRSSRGRDWGLLPLLQPSSPSSLLSAKLIPLPSAPFPQVIMALVDVLREALGCHIEQGTKRRRSEGARIKDSPLGGVNKRQRLGGQEKSFEEGKEEPQGCAGDHSENEVEEMVIEVRETPQDWALLHSGPPEEELPLMTANCLDKAAEHNPMKPEVAGEGSQGETGKEASHPSSVSWRCALWHQVWQGRRRARRRLQQQTKEEGRGGPTTGAEWLAMEARVTQELKGPNSEQERPPGEPLLSFVASASQAEQTLTVAPLQDSQGLFPGLHHFLQGFIPQALKNLLK
What is the function of this protein?
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs.  Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1.  In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs.  In addition to adenylyltransferase activity, also has uridylyltransferase activity.  However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase.  Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA.  Not involved in replication-dependent histone mRNA degradation.
What are the official names of this protein?
Speckle targeted PIP5K1A-regulated poly(A) polymerase, Star-PAP, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus speckle.
Protein: TPX_CLOPA
Sequence: MKVTFQGNEVTLQGKEVKVG
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, CP 42, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: RL2_PSEU2
Sequence: MAIVKCKPTSPGRRFVVKVVNQELHKGAPHAPLLEKKSKSGGRNNNGRITTRHIGGGHKQHYRLVDFRRNDKDGIAATVERIEYDPNRTAHIALLLYADGERRYIIAPKGVSAGDQLIAGALAPIKPGNALQLRNIPVGSTVHGIELKPGKGAQIARSAGASAQLIAREGVYVTLRLRSGEMRKVLSECRATLGEVSNSEHSLRSLGKAGAKRWRGVRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGFPTKGAKTRGNKRTDKMIVRRRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SUB2_CRYNJ
Sequence: MINSTNLNLTIKMSRPDEEELVDYDEAAEEILPPAPAAETNGDKADGDKKGSYVGIHSTGFRDFLLKPELLRAISDLGFEHPSEVQQECIPQAILGTDVLCQAKSGMGKTAVFVLAALQQIEPVDGEVSIIILCHTRELAYQIKNEFTRFSKFMTNVRTGVFYGGTPISADQEILANKEKCPHIVVGTPGRTMALVRDKKLNASKVKHFVLDECDKMLEQLDMRRDVQEIFRATPHHKQVMMFSATLSKDIRATCKKFMQSPLEIYVDDETKLTLHGLQQFYLKLEEREKNRKLNDLLDNLEFNQVCIFVKSVQRATQLDALLQECNFPSICIHSGLQQAERISRFQQFKAFEKRILVATDIFGRGIDVERVNVVINYDAPSDADSYLHRVGRAGRFGTKGLAISFVSSDADQEVLQRIQERFTVAIPTLPETVDPATYMTS
What is the function of this protein?
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus.  SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly.  May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase SUB2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL7_PECAS
Sequence: MSITKDQILEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPAEVAEEKTEFDVVLKAIGANKVAVIKAVRSATGLGLKEAKDLVESAPAVMKEGVSKDDAESLKKSLEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: CINA_STRZP
Sequence: MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADVRHIAVMHAFNLVRKALLSD
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: FBK73_ARATH
Sequence: MTLPELPKDLVEEILCFVPATSLKRLRSSCKEWNRLFKDDKRFARKHIEKAAKQFQPLTLTKNYRICPINVNLHGTTPSLEVKNEVSLVDPHSKNSAAQFNIDRVFHCDGLLLCTSQKDSRFVVWNPLTGVTKWIELGDRYNEGMAFILGYDNKSCNKSYKAMSFNYLDKDSEIYEFSSDSWRVIDDIIKPPHYMDYFRECFSLKGNTYWLGIDRRRRPPDLRITLIKFDFGTERFGYVSLPPPCQVHGFEASNLSVVGDEKLSVLVQGGSTSKTEVWVTSKIGEANVVSWSKVLSLYPKPDVGFWHGLSFLLDEEKKVVLCCKSKGWMEEEDEENVYSVGEDTKFILLNFGVQTIGGYSPIIVNYVPSLGQIELAGSKRKRDY
What are the official names of this protein?
F-box/kelch-repeat protein At3g44120.
Protein: RS8_MYCTU
Sequence: MTMTDPIADFLTRLRNANSAYHDEVSLPHSKLKANIAQILKNEGYISDFRTEDARVGKSLVIQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SFSA_CALMQ
Sequence: MLGFTINKPDVEGVFIKRINRFLGIGLINGVESLVHIHDPGRLKELLKPGIKFYAYHKDSGKTRFYLTAVDLGNELVLINSAIHNNVAAWLIENGLILKGYEVLRREPRFSGGRFDLMLKSPKGGYTMVEVKGVTLEEDGVAKFPDAPTLRGARHMIKLAKAIEEGYEAYVIFLVLRSNALLFTPNVSLDPRFSNALKYAIEHGVKVLAYKLALTRDWVLLPMGRVNVIL
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.