PharMolix/UniProtQA huggingface dataset:
Protein: CLIC5_HUMAN
Sequence: MNDEDYSTIYDTIQNERTYEVPDQPEENESPHYDDVHEYLRPENDLYATQLNTHEYDFVSVYTIKGEETSLASVQSEDRGYLLPDEIYSELQEAHPGEPQEDRGISMEGLYSSTQDQQLCAAELQENGSVMKEDLPSPSSFTIQHSKAFSTTKYSCYSDAEGLEEKEGAHMNPEIYLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS
What is the function of this protein?
Required for normal hearing (PubMed:24781754).  It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity).  Can insert into membranes and form poorly selective ion channels that may also transport chloride ions.  May play a role in the regulation of transepithelial ion absorption and secretion.  Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315).  Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity).
What are the official names of this protein?
Chloride intracellular channel protein 5.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Membrane; Single-pass membrane protein. Apical cell membrane; Single-pass membrane protein. Cytoplasm. Note=Associates with the cortical actin cytoskeleton (PubMed:10793131, PubMed:15184393). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (By similarity). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (PubMed:20335315). May localize to the centrosome in lens epithelial cells (By similarity). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome.
Protein: GDPD5_ARATH
Sequence: MILTRCLPLIWLSLLTVCAAGRTLHPLPVKGPKTVKLQLQTSRPYNIAHRGSNGEIPEETTAAYLKAIEEGTDFIETDILSSKDGVLICFHDCILDETTNVASHKEFADRKRTYDVQGFNITGFFTFDFTLKELKQLRIKQRYAFRDQQYNGMYPIITFEEFLTIARDAPRVVGIYPEIKNPVLMNQHVKWPGGKKFEDKVVETLKKYGYGGSYLSKKWLKKPLFIQSFAPTSLVYISNLTDSPKVLLIDDVTMPTQDTNQTYAEITSDAYFEYIKQYVVGIGPWKDTIVPVNNNYVLAPTDLVKRAHAHNLQVHPYTYRNEHEFLHYNFSQDPYKEYDYWINEIGVDGLFTDFTGSLHNFQEWTSPLPDTSKSPRQLLSQIASLVLPYAKA
What are the official names of this protein?
Glycerophosphodiester phosphodiesterase GDPD5, Glycerophosphodiester phosphodiesterase 5, ATGDPD5.
What is the protein family that this protein belongs to?
Belongs to the glycerophosphoryl diester phosphodiesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall. Vacuole.
Protein: CO8G_HUMAN
Sequence: MLPPGTATLLTLLLAAGSLGQKPQRPRRPASPISTIQPKANFDAQQFAGTWLLVAVGSACRFLQEQGHRAEATTLHVAPQGTAMAVSTFRKLDGICWQVRQLYGDTGVLGRFLLQARDARGAVHVVVAETDYQSFAVLYLERAGQLSVKLYARSLPVSDSVLSGFEQRVQEAHLTEDQIFYFPKYGFCEAADQFHVLDEVRR
What is the function of this protein?
C8 is a constituent of the membrane attack complex.  C8 binds to the C5B-7 complex, forming the C5B-8 complex.  C5-B8 binds C9 and acts as a catalyst in the polymerization of C9.  The gamma subunit seems to be able to bind retinol.
What are the official names of this protein?
Complement component C8 gamma chain.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_YERPA
Sequence: MSLSVEAKAKIVADFGRGTNDTGSSEVQVALLTAQINHLQGHFSEHKKDHHSRRGLLRMVSTRRKLLDYLKRQDVARYASLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: LIG3_PHACH
Sequence: MAFKQLFAAISLALSLSAANAAAVIEKRATCSNGKTVGDASSCAWFDVLDDIQQNLFHGGQCGAEAHESIRLVFHDSIAISPAMEAQGKFGGGGADGSIMIFDDIETAFHPNIGLDEIVKLQKPFVQKHGCTPGDFIAFAGAVALSNCPGAPQMNFFTGRAPATQAAPDGLVPEPFHTVDQIINRVNDAGEFDELELVWMLSAHSVAAVNDVDPTVQGLPFDSTPGIFDSQFFVETQLRGTAFPGSGGNQGEVESPLPGEIRIQSDHTIARDSRTACEWQSFVNNQSKLVDDFQFIFLALTQLGQDPNAMTDCSDVIPQSKPIPGNLPFSFFPAGKTIKDVEQACAETPFPTLTTLPGPETSVQRIPPPPGA
What is the function of this protein?
Depolymerization of lignin.  Catalyzes the C(alpha)-C(beta) cleavage of the propyl side chains of lignin.
What are the official names of this protein?
Ligninase LG3, Diarylpropane peroxidase, Lignin peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ligninase subfamily.
Protein: MATK_PARTT
Sequence: MEELQLQGYLEKDGFRQQNFLYPLIFQEYIYTLAHDHGLNSSIFYEPMEIVGLGYDNKSSSVLVKRLITRMYQQNSLIYSMNDFNQNRFVGHNNSFYSNFYSKMVSEGFAVIVEIPFSLRLVPSSEEIPKSQNLRSIHSIFPFLEDKLSHLNYVLDILIPYPIHLEILVKILQCWIQDVPSLHFLRFFLHEFHNWNNLITPTKSISVFSKENKRLFRILYNSYVSEYEFVFVFLRKQSYYLRSTSSGAFLERTHFYVKIEHLIDVCHNHFQKILWFFKDSFMHYVRYKGKAILASRGTYLLIKKWKCYLVNFWQYNLNFWSKPYRIHINPFSNYSFYFLGYISSVLINPSAVKNQMLENFYLVDTLTQKFDTIVPVIPLIGSLSKAKFCTILGHPISKPIWAELSDSDIIDRFGRICRNLSHYHSGSSKKQSLYRIKYILRLSCARTLARKHKSTVRNLLQRLGSGLLEEFFTEEEQVISPIFQKTTLFPLHGSHRERIWYLDITRINDLANYLDWS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FLIW_BORGP
Sequence: MINEKSIGFDFPEGILGFENIKKFIIKDSKYKPFSIMQSINKEVSFLVTSPFNFLSEYLPNIQEKDWSDIKAKEEDERVILCIINMHVNDYKDITANLKAPIIINKKKLLGKQAICTNEKYSLHHKVFKE
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF287_IIV3
Sequence: MDTLLHKDTIVAEWCDEIITRQSRENHNSLVGFRDRNRVVKHHIQQILDHLKGQNISKLAHVQDPKIAEALRTLIAWLKSNERFRPSTEPPLTDRQLEEAFSQLYLGDWAYVDRKYDDPVIPGQNFALFSFLPTVGAQPDADGVYGFLKIRGTFDRAEQAEDKARELIQYFTANTIKACKVGTPVPVAISQPSTEAIEIPPPKNGPFETDGPTDLKYQQLIQAQSMDEQKQIQEIYQNVEKLKEDVTKNPANKEPMQVYLELLQKMATCAWTYSQAQKTKDDMKSIILSDRLKLEEMDQKYPHLQNEYRKVYDEKNQQLGLDQCSDDMALGIRKYFGSRADLDF
What are the official names of this protein?
Uncharacterized protein 056L.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 287R family.
Protein: FBSB_SYNJA
Sequence: MDNKLGLEIIEVVEQAAIAAARWMGKGDNKTADQVAVEAMREKLNQIPMRGRIVIGEGTRDEAPMLYIGEEVGICTRPDAEQFCRVEELVEIDIAVDPCEGTNLVAKGQNGSMAVLAISEKGGLLHAPDIYMQKLAAPPQAKGKVHLDYPPEKNLQIIAESLDREVSDLTVVVMDRKRHVDLIRQIREAGARVKLITDGDISAALSAGFNGTGIHALMGIGAAPEGVISAAALRCLGAHFQGRLIYDPEVVQAGTYLPPVEETRRQLKEQGIEDPDKVWECEELASGKEVLFAATGITDGDLMRGVRFFGGGARTETLVISSQSRTVRFVDTIHMKDGQQPRSLQLR
What is the function of this protein?
Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-phosphate and sedoheptulose 7-phosphate, respectively.
What are the official names of this protein?
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase, FBPase class 2/SBPase.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 2 family.
Protein: VP43_NPVAC
Sequence: MDKRANSRKPFLFYNEDYYCEKPKRYFHTNKVIFEKLDSYATNINRCRELLTDFFDYCLPKYYRRKNKFTLLFRLLEPVIKQAGASALTTVSNDQCRWLEINQFSGWEQRDNQYAHKWLIKVVGADMGQQILFIIKQVTKKFKTCNLGFHNYYKLFRRCLSILLFKHKEVFVQCLQVILKAAMPVKKKGVVKSNYAFAVTNALHYYIVDNPHLLCKDINVAIKVRRLLIKHEMLPTEKQIKLSFEKCSKGIEVPLYEKLLLNHMMRINDDNLQWPSLINNKKIMEWNANRCFDESNKILHVYIGQYYTSSCRRVKKSFFKYNGWNRQGRFCRTEKFCHLVNLQLNKDGSKKLKRVQRKLINCK
What are the official names of this protein?
43 kDa protein.
Protein: CHB3_LYMDI
Sequence: MSAKIILVFCAQALFVQSALSQCTSRATVAADRGIIGGYGLGAPYGLAYGLEAPLGLGYGLGAPCGLGGPAIDITPTIGGGLPVSSASAIAPVGLAVASENVYEGILAAAGELPFVGTVGVEGVLPTAGAGAVHHSCGNGINAMASRDAAFAPGYAGAYGIGLGAYGLGVPALEVPALGYRAGWRGCGCGL
What is the function of this protein?
This protein is one of many from the eggshell of the gypsy moth.
What are the official names of this protein?
Chorion class B protein Ld34.
What is the protein family that this protein belongs to?
Belongs to the chorion protein family.
Protein: DNAT_ECOL5
Sequence: MSSRVLTPDVVGIDALVHDHQTVLAKAEGGVVAVFANNAPAFYAITPARLAELLALEEKLARPGSDVALDDQLYQEPQTAPVAVPMGKFAMYPDWQPDADFIRLAALWGVALREPVTAEELASFIAYWQAEGKVFHHVQWQQKLARSLQIGRASNGGLPKRDVNTVSEPDSQIPPGFRG
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: AROA_SALPB
Sequence: MESLTLQPIARVDGAINLPGSKSVSNRALLLAALACGKTVLTNLLDSDDVRHMLNALSALGINYTLSADRTRCDITGNGGALRAPGALELFLGNAGTAMRPLAAALCLGQNEIVLTGEPRMKERPIGHLVDSLRQGGANIDYLEQENYPPLRLRGGFTGGDIEVDGSVSSQFLTALLMTAPLAPKDTIIRVKGELVSKPYIDITLNLMKTFGVEIANHHYQQFVVKGGQQYHSPGRYLVEGDASSASYFLAAGAIKGGTVKVTGIGRKSMQGDIRFADVLEKMGATITWGDDFIACTRGELHAIDMDMNHIPDAAMTIATTALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPAKLQHADIGTYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARMSTPA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_PSEMY
Sequence: MTDYKATLNLPDTQFPMKAGLPQREPQTLQRWNEIGLYSKLRKIGEGRPKFVLHDGPPYANGSIHIGHAVNKILKDIITRSKTLAGFDAPYVPGWDCHGLPIEHKVETTFGKNQPADLTRERCRTYASEQIEGQKADFIRLGVLGDWDNPYKTMDFANEAGEIRALAEMVKQGFVFKGLKPVNWCFDCGSALAEAEVEYQDKKSDAIDVAFPIEDADKLAAAFGLSELSKPTAIVIWTTTPWTIPANQALNVHPEFTYALVDTGERILLLAEELVESCLQRYGLQGQVIATAPGAALELIRFRHPFYERFSPVYLAEYVELGAGTGIVHSSPAYGEDDFRTCKAYGMSNDDILSPVQSNGVYTPDLPFFGGQFIWKANPAIVEKLAEVGALLKHQPIQHSYMHCWRHKTPLIYRATAQWFVGMDTQPKQGGTLRERALAAIEQTQFVPAWGQARLHSMIAGRPDWCISRQRNWGVPIPFFLHKATGELHPRTVELMEEVAKRVEQEGIEAWFKLDAAELLGAEAADYDKINDTLDVWFDSGTTHWHVLRGSHGLGHTTGPRADLYLEGSDQHRGWFHSSLLTGSAIDGHAPYKALLTHGFVVDENGRKMSKSLGNVVAPQEVNDSLGADIMRLWVASTDYSGEMAVSKVILQRSADAYRRIRNTARFMLANLNGFDPAKDLLQPEQMLDLDRWAVDAALRLQEEIIEAYADYRFWNVYSKVHNFCVQELGGFYLDIIKDRQYTTAADSVARRSCQSALLHISEALVRWIAPILAFTAEEIWQFLPGERNESVMLNTWYAGLERLPEGFELDRAYWDRVMEVKAAVNKELENLRTAKAIGASLQAEVTLFCDDAKQADLAKLGDELRFALITSAAQTAPLADAPADAVVTEVEGLKLKILKSAHAKCGRCWHFRADVGSHAAHPELCGRCVSNIEGEGEVRKHA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_CHLL2
Sequence: MNISVTATPVKKIKTELLVVPFTTGALKKNADGILQDLGYDAVVLRDFKADAGELVILYGAAGKAIAARAALLGMGEGKKVTDFRKAAAALALKAMDMKIESVAVDFSGVKGFASSAKSSVASICSAFIEGCYTGSYRFDRLKSDKLKKKKDESDKTKEISELVLRAEPAQLSAVEDGLAAGIITGSCQNMARDLVNLPGNLLQAEDISAAAVESGKRCGFEVNVFGKEEIEALGMGGLLAVNRGSQHPPTFTVLDYKPEGKVAKTVALVGKGVTFDSGGISLKPSEGMGEMKSDMSGAASVIGAVEAVARLGLPIRVIGLIPATDNMPSGSATKPGDVITTYSGITVEVGNTDAEGRLILADALTYAKKQYNPDVIIDLATLTGACIVALGYTVAGLFSNDDRLADDIFEAGQITGEKVWRMPLWEEYDEMIKSDVADVSNLGARGAGSVTASRFLEKFIDGHKKWAHIDIAGPSFSAKGAKVSGATGFGVRLLVELLKKWS
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AEP2_ASHGO
Sequence: MMVDFSPSRRRMGTQELSLKPQVETPGIKLLAVMFCRYHLIRQLKQVQAASRTRYAHSVPQSRPTLKERLAALHEKQQLSLLPPDAVKRVSENNPAVLIDCDARTLLQLFLAALQTDPQKTTLSELLSQEEGFSVFIHRLLPTYTPSSDLKHLVSKDGTTALLQKLYGFYREQFADAPIGRPSPGRLHDANSFARWFMAESKLRLARTVFAELVGNPTELAKLPRDTETIITLLQLHLGAKHIFWRDPGNSVGRGGQLFTPAHMAVVTAYNSLGEETLLRLLRLLQSDPQWKSVCSPDLDRNIILALAFHNRLDLVHAQAARYYAPAAPGHGLPSTPLLPDGALVGAVVTAFAFKHQLAQGLAIAYQFLDRFTHLPNEHELWKIIFTWLARRHPTGSQGAALYDEAWSKMRTRYAEHGQPTPYDYSIARASYRIVRRDSSLRRVRALLNDYMSPLYQQPAVAPRDRLLLLKCQAHIVGRLVRARRNSAAADFVDQWALDSEARSHLLEHIAARASSRTDADDDDAGDGLYLTGAPLW
What is the function of this protein?
Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.
What are the official names of this protein?
ATPase expression protein 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AEP2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y2977_LEPIN
Sequence: MLDKNTNLTHQSKIEFVNSNLRGIGFVNNTKIEVPYSLPGDVYNVTFFKKKRRKPSAKLELVSQTQRSFIPPCSAFTKCGGCCAQHISYQDQFRYKTSSLLESYKKDFEIVPTLYPAQKTFYYRNRMDFAVFPGPIVGQREAGSFRHIVDLETCLIQSKESNEELYRFRNLISKFPNLPYDRKSDSGFLKYFTLRKAKNTSELMTILTFVEEFKNTIEEKEFENVCLKSLKADHILFCFNRRKGEISATGEIKILKGMDSYKELVCGKEFRVPFDSFFQPNPEGFQPILDFIEKEIPDSFDHLVDLFCGSGFFSRIFAHKFLKITGIDSIESSLEIARKQMSLDFPKIDSSYLKVDLFSKNSSSKLKVLFSSSDKDVLIADPPRAGLGEFVLDALKDSKVSYFFYVSCNPTSQKSDLWKLKDFFQIQKILITDPYPQTPHLESVAFLKRKNFTT
What are the official names of this protein?
Uncharacterized RNA methyltransferase LA_2977.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: RSMA_NITMU
Sequence: MQHTPRRRFGQNFLVDSQTVTDIVHALHPRREDVMVEIGPGLGALTQPLLQSLEHLHVVEIDRDIVKRLRNEFSAKRLTVHEGDALEFDFSSLGESLRVVGNLPYNISTPLLFHLSRFTDHLRDMHFMLQKEVVARMVAKPSTSDYGRLSVMLQCRFEMEQLFIVPPECFHPPPKVQSAVVRMIPLKKPLIEASQEKLFAEIVSAAFSQRRKILRNTLRDYLTGEDYLKLGIDSNLRAENLSITQYVAITNYFNRVRSG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3S1C_LATLA
Sequence: RRCFNQQSSQPQTNKSCPPGENSCYRKQWRDHRGTIIERGCGCPTVKPGVKLRCCQSEDCNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin C.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRB_XANC5
Sequence: MTTMQLDSDGRLRHLLTLEGLPRTTLLQLLDRAGQIRDAAVGRVGKRSVLAGTAVCTLFFEPSTRTRSSFHLAAQRLGADVLNFDASTSSTRKGETARDTLKNLEAMGVRGFVVRHPDDGAVEALATAAGEGTALINAGDGRSAHPTQGLLDMLTLRQAKGTDFSKLKVVIVGDVKHSRVARSDLHALRTLGAGEIRVCGPASLLPDDGILEGCVVGQDFDAMLEGADALMMLRLQRERMEEGLVPSLEQYHTEYGLTRERLARAGRDAAVLHPGPINRGVEITDEVADGAQSCVLRQVANGVAVRMAVLETLLG
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: SPINW_CHICK
Sequence: MKTPFGKSPAQRSRADAGHTRVSASMMKKRTSHKKHRNNVGPSKPISQPRRNIVGCRIQHGWKEGSGPITQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELHKDERVSALEVLPDRVASSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPIMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
What is the function of this protein?
May play a role in mitosis.
What are the official names of this protein?
Spindlin-W, chSpin-W.
What is the protein family that this protein belongs to?
Belongs to the SPIN/STSY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: OTC_STAAN
Sequence: MKNLRNRSFLTLLDFSRQEVEFLLTLSEDLKRAKYIGTEKPMLKNKNIALLFEKDSTRTRCAFEVAAHDQGANVTYLGPTGSQMGKKETTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEVLKKDYADINFTYVGDGRNNVANALMQGAAIMGMNFHLVCPKELNPTDELLNRCKNIAAENGGNILITDDIDQGVKGSDVIYTDVWVSMGEPDEVWKERLELLKPYQVNKEMMDKTGNPNVIFEHCLPSFHNADTKIGQQIFEKYGIREMEVTDEVFESKASVVFQEAENRMHTIKAVMVATLGEF
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T23O_RHOJR
Sequence: MGVQANTRAIEKDIVTDFSERMSYASYLDLDTLLSAQKPVSRPEHHDELLFIIQHQTTELWLKLVLHETLAARAAFDEDDIGRALKCVARVKHIQKTLTEQWSVLATLTPTEYSEFRRFLGNSSGFQSYQYRAVEFVLGNKNAGMLAVFEADPAAHDLLGRLLAEPSLYDAFWQCLSRLGYDVPASALDRDVTAAYTLNEDLLPLIKFVYENHDEHWAVYEAFEEFVDLEENFQLWRFRHMRTVLRTIGMKSGTGGSSGVGFLQKALDLTFFPELLAVRTEIGR
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: FAA30_MYCTO
Sequence: MSVISTLRDRATTTPSDEAFVFMDYDTKTGDQIDRMTWSQLYSRVTAVSAYLISYGRHADRRRTAAISAPQGLDYVAGFLGALCAGWTPVPLPEPLGSLRDKRTGLAVLDCAADVVLTTSQAETRVRATIATHGASVTTPVIALDTLDEPSGDNCDLDSQLSDWSSYLQYTSGSTANPRGVVLSMRNVTENVDQIIRNYFRHEGGAPRLPSSVVSWLPLYHDMGLMVGLFIPLFVGCPVILTSPEAFIRKPARWMQLLAKHQAPFSAAPNFAFDLAVAKTSEEDMAGLDLGHVNTIINGAEQVQPNTITKFLRRFRPYNLMPAAVKPSYGMAEAVVYLATTKAGSPPTSTEFDADSLARGHAELSTFETERATRLIRYHSDDKEPLLRIVDPDSNIELGPGRIGEIWIHGKNVSTGYHNADDALNRDKFQASIREASAGTPRSPWLRTGDLGFIVGDEFYIVGRMKDLIIQDGVNHYPDDIETTVKEFTGGRVAAFSVSDDGVEHLVIAAEVRTEHGPDKVTIMDFSTIKRLVVSALSKLHGLHVTDFLLVPPGALPKTTSGKISRAACAKQYGANKLQRVATFP
What is the function of this protein?
Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to a multifunctional polyketide synthase (PKS) for further chain extension.
What are the official names of this protein?
Probable long-chain-fatty-acid--AMP ligase FadD30, FAAL, Acyl-AMP synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PLSY_STRR6
Sequence: MITIVLLILAYLLGSIPSGLWIGQVFFQINLREHGSGNTGTTNTFRILGKKAGMATFVIDFFKGTLATLLPIIFHLQGVSPLIFGLLAVIGHTFPIFAGFKGGKAVATSAGVIFGFAPIFCLYLAIIFFGALYLGSMISLSSVTASIAAVIGVLLFPLFGFILSNYDSLFIAIILALASLIIIRHKDNIARIKNKTENLVPWGLNLTHQDPKK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VP4_ROTMB
Sequence: MASLIYRQLLTNSFTVDLSDEIETIGAEKTKNVTVNPGPFAQTGYAPVNWGPGETSNSTTVEPVLDGPYQPIAFSPPSEYYILLSPTVPGVVVECTNTVDRWIATIAIEPNVSKTKRTYTLFGITEQLTVENSYADKWKFIDFLKASTNGSYARYNILLSSTKLCAVAKHTDRLYSYIRETPNAGQAYYAFSHNIFNLTAHCDFYIIPWAQQSLCTQYINTGLPPIQNTRNVVARHLSARSIITRRAQANEDIVVSKTSLWKEMQFNRDITIRFKFANAIIKSGGLGYKWSEISFKPANYQYTYTRDGEEVTAHTTCSVNGVNNFDFFGGSLPTDFGISRYEVLKENSFVYIDYWDDSQAFRNMVYVRSLAADLNTIECTGGTYEFSLPVGQWPAMTGGAVSLRVAGVTLSTQYTDFVSLNSLRFRFRLSVEEPPFSITRTRVSGLYGLPAANPNNGKEYYELAGRFSLISLVPSNDNYQTPIMNSVTVRQDLERQLGELREEFNALSQEIALSQLVDLALLPLDMFSMFSGIKATLDVAKSMATNVMKKFKSSGLATSVSAMTESLSDAASSVSRSNTIRSISSTSSAWTDVSSRVADLDNAASTVSTQTATISRRLRLKEITTQTEGMNFDDISAAVLKIKLDKSAQIAPNTLPDIVTEASEKFIPNRSYRIINNNEAFEAGTDGRFFAYRVDTLEELPFDVQKFANLVTESPVISAIIDFKTLRNLNDNYGISKEQAFNLLRSDPRVLREFINQGNPIIRNRIEQLIMQCKL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.