PharMolix/UniProtQA huggingface dataset:
Protein: KLH21_BOVIN
Sequence: MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLTNCLDMQDFAEAFSCAGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLESVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYHPDMDLWSLVDCGQLPPWSFAPKTVTLNGLMYFIRDDSAEVDVYNPTKNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPLGGRGFELDGGSSDMDVGQPRPPQNPAELH
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis.  The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB.  Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).
What are the official names of this protein?
Kelch-like protein 21.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region.
Protein: FDNGA_DESVH
Sequence: MKTTRRSFLKLVGVSVVGLSLGQLGFDLEDAQAYAVKLKIEGAKEVGTVCPFCSVCCQVIAYVRNGKLVSTEGDPDFPVNEGALCAKGAALFSMYTNPHRLTKPLYRAPHSDKWVEKDWDWTLNQIARRVKDARDKDMILKNDKGQTVNRLESIFMMGTSHASNEECAVIHQAMRGLGVVHMDHQARVUHSPTVAALAESFGRGAMTNHWIDIKNTDAVLIIGSNAAEHHPVAFKWIMRARDNGAVLMHVDPKFSRTSARCDFHVPLRSGTDIAFLGGMVNHIIAKDLYFKDYVANYTNAAFVVGKDYAFEDGIFSGYDPKTRTYDRSKWEFEKGPDGGPVMDPTLKNERCVFNLMKKHYERYTLKNVSDVTGVSEENLLRVYDAFCATGRPDKAGTILYALGWTQHTVGVQNIRTSTLIQLLLGNIGVAGGGINALRGEPNVQGSTDHALLYHILPGYNAMPVAQWQTLADYNKANTPVTTLKNSANWWSNRPKYVASLLKGWFGDAATPENDFCYEYLPKLEKGEDYSYMYVMDRMYHGKLKGGFIFGVNPMNSFPNTNKMRAALDKLDWLVCSELHNSETTDNWKRPGVDPKACKTEVFLLPSAHRVEKAGTISNSGRWLQWFDKAVEPGQARNFADIFVPLVNKIRALYKAEGGTLPDPVLKLHWTDKFDPEEWTRRINGFFWADTKVGDKEYKRGQLVPAFGQLKDDGSTSSLNWLYTGSYTEEDGNKSKRRDARQTPMQANIGLFPNWSWCWPVNRRILYNRASVDVNGKPWNPKKAVIEWDGAKWVGDVPDGPWPPMADKEKGKLPFIMNKDGFAQFYGTGRMDGPFPEHYEPAETPLDSHPFSKQLSSPVYKFHTSDMDQIAKAADPKYPIVLTTYSLTEHWCGGGETRNVPNLLETEPQLYIEMSPELAEEKGIKNGDGVIVESIRGRAEAIAMVTVRIRPFTVMGKTVHLVGMPFAYGWTTPKCGDSTNRLTVGAYDPNTTIPESKACLVNVRKADKLTEIA
What is the function of this protein?
Alpha chain of the formate dehydrogenase (FDH) that catalyzes the reversible two-electron oxidation of formate to carbon dioxide.  The alpha subunit of formate dehydrogenase forms the active site.
What are the official names of this protein?
Formate dehydrogenase 2 subunit alpha (cytochrome c-553), FDH2 subunit alpha (cytochrome c-553), Formate dehydrogenase large subunit (cytochrome c-553).
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SLX4_CHAGB
Sequence: MAHHDSVLVISSSPDFPSICDLLPKATRQPSLRSGSNAAPVSNDAPAAFTSAANIWQSSRARHLEGAEISNIGPSQSATTAADLATVPAESPIKSGVEGPTLPLGGDKKKPRTAGARKKKGKTETIEPPLALDMAVADGPVAVAPPKKSGRKPRAKKDATLAQTTLPKGKVTKTAAREITKAQKKAETVSRHFTPHTSAPPELVAGPIDDSPSVFEPAMARRMDWTPPRESASVHCLADSSMEKEVSSSALSLQDHVFKNLQDTYGRTMEASGYIGAALPLTSMDVLGKRKLVEMVSCVGHRQEIPQASPTKPKVVKKKPRTITELATAAYRRPEEAERSTLSRQQDTHIPSGNLELPSEQLTAASKSASAKPKAAKKAPKPRATKKKQSPPEPILLSPTSAMRQVSNQDFVFGTASQLATEDDPVLLRALHEAMKVSNQADSDPFATPSPGNSNLAIRRRSGAGLWAAGARYGDGDLLDAEVLDLTRSSPLTLAQFAQNPPPPCPEAVLADKPPVESAYIEIEMSDDTLDLTISPPVGSPKTLPPCPPRPGGQAVRHKDSNLAVSGRPQTPPQEADFDPPPSNQEQHQLLLSQSNTPQQPQPAPPPPPSFELYTDARLAKEVASYGFKVVKKRTAMIALLNRCWESRNKTALGSTAAQAAMSTSAPNQAASPSRPRGRPRKDSLTATTEVVQAPSPAKKGRKKAGVVSGAGSEVPQPEKWPRGRPRKDSAASVSSITAPAATNPRRRSAAISDVDSDEPQVEKRSRGRPKKDATTSPATRATRAKAPPSPKRAKSPCTTQPAPTTPRRRKAPAKQIFEIPDSGSDDPFASSAPSSPDQHSDLFSSPPAVDLSVTEDTEASLIASPTTQDVSLFGYITRAVASAPPTKDPANPSWHEKMLMYDPIILEDLTAWLNAGRLDQVGFDGEVAPGDVKKWCESKSVCCLWRVNLRGKERKRF
What is the function of this protein?
Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX4.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RPOC_RICCK
Sequence: MSLVNFYGQLSNTQQFDQIRINIASPDQVRSWSFGEVTKPETINYRTFKPEKDGLFCARIFGPVKDYECLCGKYKRMKNRGIICEKCGVEVTVSRVRRERMGHIELAAPIAHIWFLKSLPSRISTLLDMTMRDLEKILYFENYVVLDPGLSILQKGELLTEEELQKAKDKYGEDAFTASIGAEVIQQMLKDLDFAKLKQELYEELQNTTSEVKKKKLVKRLKLVEDFLESENKPEWMIIDVLPVIPPEIRPLVMLDGGRFATSDLNELYRRVINRNNRLKKLIESKAPDIIVRNEKRMLQEAVDALFDNGRRGRAAKNANKRPFKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYSKLELYGIATTIKAAKRMVEAEKPEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPLLIEGKAIQLHPLVCAAFNADFDGDQMAVHIPLSIEAQLEARVFMMSTNNILSPANGRPIIVPDKDIVLGLYYLTIAFDNEVGEGLMFSDLAEMEHALYNKFITIHTKIKYRRNQLNAEGKMVPVIVDTTYGRLMVGELLPSNPNIEFKFINKQLTKKDISLVIDLVYRHCGQKATVIFADQLMKLGFKYACSSGISFGMDDMVVPESKSTHINETQLEIKEFEQQYSNGLITYGEKYNKVVDAWSRCTDRVANDMMKEIATPPINDEPNHQKINAIYMMAVSGARGSFQQIKQLGGMRGLMTKSNGQIIQTPIISNFKEGLTEFECFNSANGMRKGQIDTALKTASSGYLTRKLVDVAQDCIITEKDCGTDKGIEVKSVIEGGEVIVSLAEKILGRTAAIDIFHPVTNDLILNKGELINEVKLEQIESAGLDRIMIKSVLTCESTTGICSICYGRDLATGTLVSEGEAIGVIAAQSIGEPGTQLTMRTFHIGGAATKGAEISSVEASYDAKVKIISRNVVINSEERKIVMSRNCELLLLDNNGNEKARHKIPYGARLLVDDGDMVIKTQKLAEWDPYTIPIITEKSGKVLFKDMVEGISIRDVTDEATGIPSKVIIESKQYSRGAELRPRIQLLDAKGEVITLSNGLEARYYLPVGAVLSVEDGVQISVGDIIARIPKESTTTKDITGGLPRVAELVEARRPKDHAVIAEVDGRVEFGKDYKSKRRIIIHPIDETMSIEYMVPKGKHVVVNEGDFVKKGDLLIDGNPVLQDILKVMGVEVLANYIVKEVQAVYRLQGVKIDDKHIEVIIRQMLQKVEITDSGGTTLLVGEKVDRHEFDEINEKAIKNGLKPAEAQLILQGITKASLQTRSFISAASFQETTRVLTEAAIAGKVDKLRGLKENVIVGRLVPAGTGYFMDKMRKAAVKLDEENSINADKG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: NA121_ACTEQ
Sequence: MNRLMILVFAAVILALASADEDVDIAKRGVPCLCVSDGPRPRGNNLSGIMWMKTGGYGGNGCPKGWHFCGKSRGFFSDCCKR
What is the function of this protein?
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.  Causes death to crabs.
What are the official names of this protein?
Delta-actitoxin-Aeq2b 1, Delta-AITX-Aeq2b 1, Ae2-1, Neurotoxin 2-1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: NIFZ_KLEPN
Sequence: MRPKFTFSEEVRVVRAIRNDGTVAGFAPGALLVRRGSTGFVRDWGVFLQDQIIYQIHFPETDRIIGCREQELIPITQPWLAGNLQYRDSVTCQMALAVNGDVVVSAGQRGRVEATDRGELGDSYTVDFSGRWFRVPVQAIALIEEREE
What are the official names of this protein?
Protein NifZ.
What is the protein family that this protein belongs to?
Belongs to the NifZ family.
Protein: TNR4_MOUSE
Sequence: MYVWVQQPTALLLLALTLGVTARRLNCVKHTYPSGHKCCRECQPGHGMVSRCDHTRDTLCHPCETGFYNEAVNYDTCKQCTQCNHRSGSELKQNCTPTQDTVCRCRPGTQPRQDSGYKLGVDCVPCPPGHFSPGNNQACKPWTNCTLSGKQTRHPASDSLDAVCEDRSLLATLLWETQRPTFRPTTVQSTTVWPRTSELPSPPTLVTPEGPAFAVLLGLGLGLLAPLTVLLALYLLRKAWRLPNTPKPCWGNSFRTPIQEEHTDAHFTLAKI
What is the function of this protein?
Receptor for TNFSF4/OX40L/GP34.  Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: ECM14_TRIVH
Sequence: MHFSVRLSLFLTLASSLPLVSAVPQHEDQAYTFSSSGRSATTDTDPALDVRQETLRTPSAWTRLRDSLVESVWGLPQRSEGCESRPRNRAKTVSRAPATLQARYGEDVVLRFTIKNQEEVKALVEASNILFLDVWGSHDDWVDIRLSRDVIPSLLGLLPPSLQTSHVPLIRDLAQTIYESYPKAGSAPPSQQGPTTRRFSPSASTSKSKPHEAKNIFFQDYQPLSVLLPWMRLLVSMFSSHTTLISVGTTAEGRDIPALRVGVHPTNNAQQAPRRRTIVISGGTHAREWISVSTVSYIAYSFITGYGKSKSITKLLEQFDYVFIPTVNPDGYAYTFSTDRLWRKNRQQTSLSFCPGIDLDHSWGYEWDGNATRSNPCSESYAGDQPFEAVEAREIASWARNEVTVNNVHFVAFVDLHSYSQQILYPYGHSCAHLPANLENLEELGAGLAKAIRKSSRENYDVKAACRGIVASCTGDKDADEPVTSSALERTAGSALDWFFHDLDVRFSYQIKLRDRGSYGFLLPREHIVPTGKEIYRAMVAMGKFLVSPHVLEEDIDGLRASEEPQDYDNDLEDGEDDKDEQDSTVFRAQADDLQS
What is the function of this protein?
Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.
What are the official names of this protein?
Inactive metallocarboxypeptidase ECM14.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Vacuole. Secreted.
Protein: AROA_AKKM8
Sequence: MNLHSHSISSLQGALTVPGDKSISHRAAILGGLAEGVTEVDNFLCSEDCLNTLRAMEQLGAKVDVLEERQGYGPVRFRITGVAMSPKAPERPIDCGNSGTGMRLLAGMLAACPFDSEMFGDASLSSRPMGRIMQPLEQMGARIEARGAKPGCAPLSIHGGRVHPISYTLPMASAQVKSAILLAGMFADGTTTVRQPAVTRDHTERLFRHFGVPCTVDGLTVGTCGPALPVAHDLTVPADISSAAFWMVAAASRPGSRLTLRQVGLNKTRNAVISALQRMGARMDIVPTSPEDAGEPYGDITVYGSDSLHGTSLLPEEIPNLIDEIPILAVAGALGRGDFIVRNARELRVKETDRIATTAANLRLMGVDVEEFDDGMVVHGGTPLKGTELSSYGDHRIAMSFLVAGLSAQGETVVTDAECINTSYPGFERDLAQFL
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_RHOOB
Sequence: MTAANVPGSSIGVDALPIRENLRGKSAYGAPQLTVPVQLNTNENPHPPTKALVDDVAESVREAARELHRYPDRDAVALRTDLAAYLVRQTGVPVTVDNVWAANGSNEILQQLLQAFGGPGRSAMGFVPSYSMHPIIADGTETEWLPIFRRADFALDVDAATAAIAERRPDVVFVTSPNNPTGHSVGIAELRRVLDSAPGIVIVDEAYAEFSDAPSALTLIDEYPSKLVVSRTMSKAFAFAGGRLGYLAAAPAFIEALLLVRLPYHLSVVTQAAARAALRHANETLGSVHALAAERVRVSKALEDTGFHVIPSDANFILFGEFTDSARAWQAYLDRGVLIRDVGIPGYLRATVGLASENDAFIVASDEIAATELTSSGDRG
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: YQBQ_BACSU
Sequence: MIELFVIKETEWLELVTESVSLEGQRYQAPRSITAKIITKQGTHSYYSVSEGDTVLFKWKGKELFRGIVFSRNPEEHWMTFTAYDMLQYLVKNKDVYVFSNQRADEIIKRLARDFQIPTTSIANTGYTIKSLVFKDDTSLYDMILKALKQTKSQTGRNYQLYSAKGKLGLRAWPDLSEVWVLETGVNITGYQYSTSINDTATKVKLRRQKDNKTYTATASDSSGISKYGVLQYVETVSDNINQAQLQERAKVKQAQKKGVKKELKSIQAIGIPDLQSGLPIYISIPEVGVKKTYWIDTDKHEFKGSTHTMTIDVVEKNSIPDGVSS
What are the official names of this protein?
Uncharacterized protein YqbQ.
What is the protein family that this protein belongs to?
To B.subtilis XkdQ.
Protein: LIPA_CHLTA
Sequence: MTDSESPTPKKSIPARFPKWLRQKLPLGRVFAQTDNTIKNKGLPTVCEEASCPNRTHCWSRHTATYLALGDACTRRCGFCDIDFTRNPLPPDPEEGAKIAESAKALGLKHIVITMVSRDDLEDGGASALVHIIETLHTELPTATIEVLASDFEGNIAALHHLLDAHIAIYNHNVETVERLTPFVRHKATYRRSLMMLENAAKYLPNLMTKSGIMVGLGEQESEVKQTLKDLADHGVKIVTIGQYLRPSRRHIPVKSYVSPETFDYYRSVGESLGLFIYAGPFVRSSFNADSVFEAMRQRETSTSSLLPNKD
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APX4_ORYSJ
Sequence: MAAPVVDAEYLRQVDRARRHLRALISSKGCAPIMLRLAWHDAGTYDVNTKTGGANGSIRYEEEYTHGSNAGLKIAIDLLEPIKAKSPKITYADLYQLAGVVAVEVTGGPTVEFIPGRRDSSVCPREGRLPDAKKGALHLRDIFYRMGLSDKDIVALSGGHTLGRAHPERSGFEGAWTQEPLKFDNSYFLELLKGESEGLLKLPTDKALLEDPSFRRYVDLYARDEDTFFKDYAESHKKLSELGFTPRSSGPASTKSDLSTGAVLAQSAVGVAVAAAVVIVSYLYEASKKSK
What is the function of this protein?
Plays a key role in hydrogen peroxide removal.
What are the official names of this protein?
Probable L-ascorbate peroxidase 4, peroxisomal, OsAPx4.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Ascorbate peroxidase subfamily.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: PSMA3_STAAW
Sequence: MEFVAKLFKFFKDLLGKFLGNN
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.  Stimulates the secretion of the chemotactic factor interleukin-8 (IL-8).  Showed the most pronounced pro-inflammatory and cytolytic activities in the host, thus contributing greatly to virulence and possibly to the development of disease.
What are the official names of this protein?
Phenol-soluble modulin alpha 3 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: AROK_DICTD
Sequence: MRSSLSFVGFMGSGKTSIGKRISLFFNIPFLDLDEYIEKKLKKSISDIFIEKGEEYFRNIETESLREAFSLYPKIVLSTGGGVVLREENRRILREKSKVIYLKGEFENLMKHLENKEEHEKRPLLKKGREELYNLWKKRLPLYESCADIIVEVDNKDIDEITFEIIERLRDD
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_COXBR
Sequence: MYIRRLNDQTANQIAAGEVVERPASVVKELIENSIDAHASCIRVDILQGGAKQIRIQDDGDGIHPEDLVLALERHATSKIAKIDDLQDITTLGFRGEALASISAVSRLTLTSRQKNAEMGYRISNISHKIMTPVPAAHPQGTTIDVQDLFYNTPARRKFLRSPATEFQHIRRIIERLALSHFTTEFLLHHNEKEIIHFKSATTISGQENRIKSILGDVFMQSALAIEFSQSGLTLKGYIAEAAYTRSQPDLQYIYVNGRFVRDKLVAQALRQAYHDVLFHGRHPAYVLYLEIDPAFVDINVHPTKHEVRFRDPQWVRDFLIHAVKTALAQAKPGIVHPLPQSTAEYNPITNFAPTPLIEGQGNLSLIQEQPAPYTQTIVHKHPLGHALAQLQGIYILSQNEKGLVIVDMHAAHERILYEKMKKQLAEVGLAMQSLLVPINLSLNPQEITAWQTNKALFARLGFEIESFGPDKIVVRRHPSLLKPKNLENLIRDVLADLITHNTTSRVGERINAALATLACHAALRAPHYLTIEEMEALLREMEKTEHGGLCNHGRPTWKQFDIAELDTFFLRGQ
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: KAR4_YEAST
Sequence: MAFQDPTYDQNKSRHINNSHLQGPNQETIEMKSKHVSFKPSRDFHTNDYSNNYIHGKSLPQQHVTNIENRVDGYPKLQKLFQAKAKQINQFATTPFGCKIGIDSIVPTLNHWIQNENLTFDVVMIGCLTENQFIYPILTQLPLDRLISKPGFLFIWANSQKINELTKLLNNEIWAKKFRRSEELVFVPIDKKSPFYPGLDQDDETLMEKMQWHCWMCITGTVRRSTDGHLIHCNVDTDLSIETKDTTNGAVPSHLYRIAENFSTATRRLHIIPARTGYETPVKVRPGWVIVSPDVMLDNFSPKRYKEEIANLGSNIPLKNEIELLRPRSPVQKAQ
What is the function of this protein?
May assist STE12 in the pheromone-dependent expression of KAR3 and CIK1.  Also required for meiosis.
What are the official names of this protein?
Karyogamy protein KAR4.
What is the protein family that this protein belongs to?
Belongs to the MT-A70-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DHE_HALSI
Sequence: MTESGPLENMLAQMEQAREYVDIDDGIYERLKSPERTLSVSLPVRMDDGSVEVFDAYRCQFDSARGPYKGGIRYHPTVSEEEVSALAGWMTWKTALVDLPFGGAKGGIVCNPKELSDNEIEQLTRRYTEGIRRMIGPETDIPAPDMNTDPRTMAWVMDTYSVYQGYAVPEVVTGKPPEIGGTDGRVEATGRGVSIITEETFEYFDTDIQDADVAIQGFGNVGSVTADLLSERGANIVAVSDVTGAIHDPTGLDIADVQAYADANGGRLEGYDAEPISNDDLLTLDVDALIPAAIEDVITVDVAERLAADVIVEAANGPTTFDAAQVLSDRGVPVVPDILANAGGVIVSYLEWVQNSQQYSWDVEEVNRDLRQRLTGAFDEMLVAYEDRNIPTLRTAAYTIALERSADAHEFRGLFP
What are the official names of this protein?
Glutamate dehydrogenase A2.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Protein: PENC_PENCR
Sequence: MTTMLTTPLSGWSQLSLSYLTLTVGALALVVVLYISIDRFPAPRWLSKKYQLIGQKDPASTTSLECPYSYIRQIYGHHHWAPFVHKLSPTLQHDDPAKYKMVLEIMDAIHLCLMLVDDISDGSDFRKGRPAAHRIYGPSETANRAYFRVTQILNQTTTGFPHLAPWLMQDLENILEGQDLSLVWRRDGLKNFPTAPSERAAAYQRMASLKTGSLFRLLGHLVLEDRSMDDTMTLVAWYSQLQNDCKNVYSTEYAKMKGAIAEDLCNGELSYPIVLAMNAPDGHWVELALQSPSPRNVRNALRAIRSDNVHQMCMAELAESSSSIQDWLALWGRKEKLDLKST
What is the function of this protein?
Prenyl transferase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:26213965).  The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (Probable).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase penC then forms 3-geranylgeranylindole (3-GGI) (Probable).  Epoxidation by the FAD-dependent monooxygenase penM leads to a epoxidized-GGI that is substrate of the terpene cyclase penB for cyclization to yield paspaline (Probable).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase penP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase penQ (PubMed:26213965).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase PC-15 which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase penD (Probable).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase PC-16 and the P. simplicissimum ptmI-ortholog not yet identified in P. crustosum, leads to the production of the prenylated form of penijanthine (Probable).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase PC-22 (Probable).  A series of oxidation steps involving 4 cytochrome P450 monooxygenases (PC-21, PC-05, PC-23, PC-20) and a FAD-dependent monooxygenase (PC-14) are required for the transformation of PC-M4 to penitrems A and E.  Synthesis of these final products is proposed to proceed via penitrems D and C (PC-21, PC-05, PC-14) and penitrems B and F (PC-21, PC-05, PC-14, PC-23) (Probable).
What are the official names of this protein?
Prenyl transferase penC, Penitrem biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GSPA_AERHY
Sequence: MYTQFFGLSEPPFSISPNPKYLYMSERHGEALAHLNYGLQDGGGFVLLTGEVGTGKTTVSRCLLQQLPTETEIAYILNPSLTERDLLAAICDEFQLPYDKDAGLKLLFDLIRDHLLANLAAGKRSVVLVDEAQHLLPGVLEQLRLLTNLETDEKKLLQVVLIGQPELQQMLRQPLLRQLAQRITARYHLLPLSHQDVDAYVRFRLQVAGCVQPIFTPKALQTLHRLSGGIPRLINLICDRALIAAFARGSHKIVHGDISLAAYEVSGIRDEGTWQSGLMVALAGALLVATGWWGWQFFGFFPERPVIKVEVPVKVDDTPEQQEQLTRAINQALEPDSAMQNLYKVWGYQTELEEATCDNAPRAGLRCQEGDASLAELQALQHPALISLTDETGGIYYATLVNLGPDKANLLIGNQSWQVDRQWLSDFWGGSYTLLWRMPKGGVALIGNNAGATQVQWLDNALSRALQQPDRKVRRFDAELKNKLQQFQREQGLNPDGIAGSNTLLRLNVMAGEPMPKLEDESQRASTPATPDTMNDEPMVTLSEEAS
What is the function of this protein?
Involved in a general secretion pathway (GSP) for the export of proteins.
What are the official names of this protein?
General secretion pathway protein A.
What is the protein family that this protein belongs to?
Belongs to the ExeA family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: G6PI_SHEHH
Sequence: MTELTQQATWQALEKHSKTLSHMRELFSTEPQRFNDMSTQACGLFLDYSKNRASQETMSLLFKLAKDTQLESKIKAMFAGEAINNTEQRAVLHTALRAPADKVIIVDGNNIVAEVQQTLAKMSEFVESLTSGSWKGYTGKAITDVVSIGIGGSFLGPKIVSQALRPYWTGELNCHFVANVDGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKAWFLGQGASQSDVAKHFVAVSSNVAKATEFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRELLAGAHEMDEHFANTPLEDNMPVIMGLFSLWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTDVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLNSHNPVGEHHVQLASNCFGQTQALMQGRTYEEALAELSSSSLNDEQKQLIAKHKVMPGNKPSNTILMDKLTPSTLGALIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLDRLTASKDADELDTSSNGLINLFRQGNI
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOT5_PICGU
Sequence: MSNLFMDLRLTHEQPTPENTLPVSEYRAFSPERFSVEDEDKHVVYSGGSGYLVTVMKNDPTTTISINPAIVPIFQEQVDLYVLNSCLLLWSATHKFGVEVPYQKIVLHALQHQQDQDVLYLQLRPGEQLNAKTESDYEPYIEITIKSSEPHSGLAICPPGTDTIPAIYDGMAQCSALHADEDESTEEDNGNELATDIILNQSVSSSADDLDIDLEADSAEHPVVAGMSVDVGYASIAGRRKRDDQDNHPAKRRS
What are the official names of this protein?
Protein LOT5.
What is the protein family that this protein belongs to?
Belongs to the LOT5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SPCS2_CAEBR
Sequence: MSDERITVVNKWDGPTVKNGLDEVVKKILNDKVGWTEQHNLMNLRLLISFIGVAFSAFACGYDFYAPFPKSKIVLLVCSVSYFICMGVLQLFQWYVEKDCFYEANEVDGKQTRKWAWSSEIKAHDDKYVLSAEFKKEGRSGQGKIIKSIGAYIDNDGEIMIPLVQREVDDLWARLIRSEQ
What is the function of this protein?
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
What are the official names of this protein?
Signal peptidase complex subunit 2, Microsomal signal peptidase 25 kDa subunit, SPase 25 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the SPCS2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SCPB_GEOTN
Sequence: MEQQETVKKDDASSARPAKAIVEALLFAAGDEGLSLAQIAAVLDVDESEAKAVIAALQEDYSREERGIQLMELAGVFLLATKKEHASYLKKLVEAPGASSLSQAALETLAIIAYRQPITRAEIEEIRGVKSDKPLQTLMARALIKEVGRAEGTGRPILYGTTAEFLDYFGLKTLEELPPLPEWADDGELEREADLFFEKLAENLSDEKP
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: EFM5_DICDI
Sequence: MSDSSDDEITLSKESLSALQDFYKSREVEQQDKFEISEDWQLSQFWYEEETSKFVANVIEQETIGGNVVVCLSTPSIYKVLHKNNNLLLNNNLFEYDKRFDVYGEKFHFYDYNNPEDGISEQLKGNVDYICLDPPFLSEECIEKVAKTIALLRKPTTRLLLLTGRIQWNNIQKYLPEMMICEFEPKHPRLQNDFFCCSNYHSKLLGLENKK
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
What are the official names of this protein?
Protein-lysine N-methyltransferase DDB_G0272708.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
What are the subcellular locations of this protein?
Cytoplasm.