PharMolix/UniProtQA huggingface dataset:
Protein: GMPPB_DANRE
Sequence: MKALILVGGYGTRLRPLTLTVPKPLVEFCNKPILLHQVEALVKAGVRHVILAVSYMSELLEREMRAQEQRLGIKISLSHEKEPLGTAGPLALARELLTDNQEPFFVLNSDVICDFPFDDMLKFHQQHGREGTIVVTKVEEPSKYGVVVYEGDSGRIHRFVEKPQVFVSNKINAGMYIFSPAMLRRIQLRPTSIEKEIFPVMAEEGQLYAMELQGFWMDIGQPKDFLTGMCMYLQSVRQQAPERLRAGPGFLGNVLVDPTAVIGQNCTIGPNVTIGAGVVLEDGVRVKRCTILKGAHIRSHSWLESCIVGWSSSVGQWVRMENVTVLGEDVIVNDELYINGANVLPHKSITDSVPEPRIIM
What is the function of this protein?
Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.
What are the official names of this protein?
Mannose-1-phosphate guanyltransferase beta, GDP-mannose pyrophosphorylase B, GTP-mannose-1-phosphate guanylyltransferase beta.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: LEPA_RUEPO
Sequence: MTDLAHIRNFSIVAHIDHGKSTLADRLIQETGTVQDRDMKEQLLDAMDIERERGITIKANTVRIDYTADDGQAYVLNLIDTPGHVDFAYEVSRSMRAVEGSLLVVDSTQGVEAQTLANVYQAIDADHEIVPILNKIDLPASECDRVAEQIEDVIGIDASGAIRVSAKTGVGIHETLEAIVKHLPAPKGTRDAPLKAMLVDSWYDSYLGVIVLVRIMDGVLKKGMRVKFMSNGTLHHVDRIGVFRPAMQMIDSLGPGEIGFLTASIKQVRDTRVGDTITNDRNGTEVALPGFKPAQPVVFCGLFPVDSAEFEDLRDAIEKLALNDASFSYEMETSAALGFGFRCGFLGLLHLEVIRDRLEREYDIELITTAPSVVYHVFMKDGEMRELHNPADMPDLSKVDHIEEPRIKATILVPDEYLGDVLKLCQDRRGIQQDLSYAGSRAMVVYDLPLNEVVFDFYDRLKSVTKGYASFDYQLTGYREDSLVKMSILVNDEPVDALSTMVHRDRAEARGRAMCEKLKDLIPRHMFKIPIQAAIGGKVIARETLSALRKDVTAKCYGGDATRKRKLLDKQKAGKKKMRQFGKVDIPQEAFISALKMDS
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CYB_OCHNB
Sequence: MTNIRKSHPLMKIVNHSLIDLPAPSNISAWWNFGSLLGLCLGIQIITGLFLAMHYTSDTLTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLFLHVGRGIYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFILPFIIAALVMVHLLFLHETGSNNPTGIISDADKIPFHPYYTIKDALGFLLLTALLLTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIAILAVMPLLHTSKQRSMMFRPISQCLFWVLVADLLTLTWIGGQPVEHPFIIIGQLASFLYFSLILILMPTCSLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KAD_MYCMS
Sequence: MNIMLLGAPGCGKGTQAEQLVNKLNFIQVSTGDLMRKEISLNTRLGLKCQEYMNAGKYVPDQIVNQIVSQFLKNTNDKLIFDGYPRTLEQAKSLEQMLDLYNKKIDYVFYIDVNDQILIKRITNRLVCPLCKASFNLETRKPKQEGLCDFDNTKLVKRSDDSLDKVQIRLQTYKEQTLPLIDYFKTNSKFIEIKADDLSAEQVFNQIKGELKI
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFNR_PSEPF
Sequence: MQLLTLPPSPALATSIRATAQVFEDPKSQALLAHLQQVAPSEASVLIIGETGTGKELVARHIHNLSNRRNRPFIAVNCGAFSESLVEAELFGHEKGAFTGALSAKAGWFEEADGGTLFLDEIGDLPMAIQVKLLRVLQEREVVRLGSRKSIPIDVRVLAATNVQLEKAINAGHFREDLYYRLNVVNLELSPLRDRPGDILPLTRHFIEAYSQRLGYGRVTISPGAEHKLRGYSWPGNIRELENVIHHTLLICRNGVIERDDLRLSNLRIDRPDDQHATADDSPEALLERAFQKLFEQQAGALHEKVEDALLRSAYRFCHYNQVHTASLLGLSRNVTRTRLIKIGELAVNKRRPTENLQGERLIQLSI
What is the function of this protein?
Involved in the dimethyl sulfide degradation pathway.  Activates the expression of sfnG and sfnF.
What are the official names of this protein?
Sigma54-dependent transcriptional regulator SfnR.
Protein: FKBP2_YARLI
Sequence: MARIIVLIVAFMALIAGVFATEEKLAKLQIGILKKISPEECTQKARKGDTVSVHYTGKLEDGTVFDSSVERGQPIQFPLGTGRVIPGWDQGILGMCVGEKRKLTIPPHLAYGKQGAGRVIPPDSTLIFTTELVSIDNDGDRDEL
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
FK506-binding protein 2, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: ARFB_ECOLI
Sequence: MIVISRHVAIPDGELEITAIRAQGAGGQHVNKTSTAIHLRFDIRASSLPEYYKERLLAASHHLISSDGVIVIKAQEYRSQELNREAALARLVAMIKELTTEKKARRPTRPTRASKERRLASKAQKSSVKAMRGKVRSGRE
What is the function of this protein?
Rescues stalled ribosomes (PubMed:21418110, PubMed:21051357, PubMed:22922063).  Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters (PubMed:21051357) or ribosomes stalled in the middle of mRNA (PubMed:22922063).  First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system or the alternative ribosome-rescue factor A (arfA) (PubMed:21418110).
What are the official names of this protein?
Peptidyl-tRNA hydrolase ArfB, PTH, Alternative ribosome-rescue factor B.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEH_BACVZ
Sequence: METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREVAFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIADALHADTRENIEIPRGMGPVQIKQAQAKVL
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: COAE_BACHK
Sequence: MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFYNEEKRLQLNKIVHPAVREEMNRRKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQSQMPLEEKVKNADEVINNDGTIMGTKTQLQAILKKWNIID
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YG063_YEAST
Sequence: MRSRVISSGRISQYSKLRNLVLYPSNTGPSNNRPCAGALGMYFLGPALK
What are the official names of this protein?
Putative uncharacterized protein YGL063C-A.
Protein: MNMA_SHEB5
Sequence: MTSIEPTHTGKKVIVGMSGGVDSSVSAYLLMQQGYQVEGLFMKNWEEDDNNEYCAAAEDLKDAQAVCDKLGIKLHTVNFAAEYWDNVFEYFLAEYKAGRTPNPDIMCNKEIKFKAFLEFADEILDADYIAMGHYVRRRDNSDGSTQMLRGVDGNKDQSYFLYTLSHEQVARSLFPVGELEKHEVREIAKEMGLITHDKKDSTGICFIGERKFTEFLGTYLPAQPGNIETPEGEVIGTHQGLMYHTLGQRKGLGIGGMKNSNDDPWYVVDKDLERNVLIVGQGGHHPRLMSTGMTVNQLHWVDRTGPVDGCHIAVKTRYRQQDVPCTLTYTDEHTLGVVFDEPVAAVTPGQSAVFYDGEVCLGGGIIDQLIRG
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPPA_SULIM
Sequence: MRIIPRTMSTQHPDNAKVPEWAKSEVIEGEDEVKEAFLAYSMYGVHEVMWDAEGKDVDTHVVRKLLSNYPDYFREHILGKDVFLTYRLPNPKVEGADRKVFAETMESIPITYDLAEKFYGNGITVPVFEVILPMTTSNLEIISVARYYEKAVANEDELELYNGVKVKDLVGEIYPKVIEVIPLVEDRDSLQNIDNIVEGYYKVIKPKYMRVFLARSDPAMNYGMITAVLSVKIALSELYKLSESLNFEIYPIIGVGSLPFRGHLSPENYEKVLEEYKGVYTYTIQSAFKYDYDYDKVKSAISSINNSRIGPAKILEKYEEDVLRKITILYTERYQPIIESLANAINDVSVLLPRRRARKLHIGLFGYSRSAGKVSLPRAISFVGSLYSIGIPPELIGISSLSNLDEKEWDIFKQNYVNFKHDLQTAARFFNWESFELIKDIWKISEDTIAKIKEDIDYAESVIGIKLGDIDYDSRKHILMSSLFLLSFKEKILQESKKYLYEMALIRRSLG
What is the function of this protein?
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 2 family.
Protein: KLK15_HUMAN
Sequence: MWLLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTKVCHYLEWIRETMKRN
What is the function of this protein?
Protease whose physiological substrate is not yet known.
What are the official names of this protein?
Kallikrein-15, ACO protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Kallikrein subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CYSG_PSESM
Sequence: MEFLPLFHNLRGSRVLVVGGGEIALRKSRLIADAGAVLRVVAPEIETQLRELVAHSGGELILRGYSESDLDGCVLIIAATDDEPLNAQVSRDARLRCVPVNVVDAPALCTVIFPAIVDRSPLVIAVSSGGDAPVLARLIRAKLETWIPSSYGQLAGLAARFRNQVKGLLPNVQQRRAFWEEVFQGAIADRQLAGQGAEAERLLIAKIAGEPPAQTGEVYLVGAGPGDPDLLTFRALRLMQQADVVLYDRLVAPTILDLCRRDAERVYVGKRRAEHAVPQEQINQQLVALAKQGKRVVRLKGGDPFIFGRGGEEIEELAAHGIPFQVVPGITAASGCAAYAGIPLTHRDHAQSVRFITGHLKNGTTDLPWSDLVAPAQTLVFYMGLIGLPVICAELIKHGRSADTPAALVQQGTTVNQRVFTGTLANLPQLVAEHEVHAPTLVIIGEVVKLREKLAWFEGAQATL
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: GPX1_HUMAN
Sequence: MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA
What is the function of this protein?
Protects the hemoglobin in erythrocytes from oxidative breakdown.  In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism (PubMed:11115402).
What are the official names of this protein?
Glutathione peroxidase 1, GPx-1, GSHPx-1, Cellular glutathione peroxidase.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPE57_MYCTU
Sequence: MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESLEDELDELDENWKGSSSDLLADAVERYLQWLSKHSSQLKHAAWVINGLANAYNDTRRKVVPPEEIAANREERRRLIASNVAGVNTPAIADLDAQYDQYRARNVAVMNAYVSWTRSALSDLPRWREPPQIYRGG
What is the function of this protein?
Plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2).  Interacts with TLR2, leading to the subsequent activation of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa-B) signaling pathways.  Induces macrophage activation by augmenting the expression of several cell surface molecules (CD40, CD80, CD86 and MHC class II) and pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-12p40) within macrophages.  Also participates in adaptive immunity by directing Th1-polarised immune responses (PubMed:25586105).  Stimulates specific humoral and cellular immune responses in tuberculosis (TB) patients (PubMed:17328725, PubMed:19467342, PubMed:23136116).  Induces a strong IgG(1) antibody response and an increased Th1/Th2 type immune response in mice (PubMed:18426397).
What are the official names of this protein?
PPE family protein PPE57.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell surface.
Protein: HPRK_XANCP
Sequence: MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: ARAG_RHIME
Sequence: MQDFLEFQSISKGYPGVQALSEVSFSVRKGAVHGLMGENGAGKSTLIRVLSGDQAADTGEIRINGEPQHYRSVRDAFNAGVIVIHQELQLVPELTVAENLWLGRFPGKAGVIDRRQLIRVVSDRLAEIGIDVDPEAKVASLSIGERQMVEIAKAVMTDARVIALDEPTSSLSSRESEILFALIDRLRSNGTVILYVSHRLDEIFRLCNSLTVLRDGRLAAHHPDISKVGREQIIAEMVGREISNIWGWRARTLGAARLTVERVSGANLPQPISFTVRAGEILGFFGLIGAGRSEMARLVYGADRRRQGKVLVDGLAVPADSPRLSIRAGVVLCPEDRKFDGIVQGRSIEENMAISSRRHFSPFGVVDKGKEAELAERFIAKLRVRTPSRHQDIVNLSGGNQQKVILGRWLSEEGVKVLLIDEPTRGIDVGAKSEIYEILYELAAQGMAIVVISSELPEVMGIADRILVMCEGRIAAEIDRSDFDEHRILAAALPDASATTATLPEQVS
What is the function of this protein?
Part of the ABC transporter complex AraFGH involved in arabinose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Arabinose import ATP-binding protein AraG.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: APOC1_ATEGE
Sequence: MRLFLSLPVLVVVLLMILEGPGPAQGAPEALDTSSGLDKLKEFGNTLEDKVREFFNRVKESDIPAKTRNWFSETLQKVKEKLRIES
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS2_HALHL
Sequence: MADVSMRQMLEAGVHFGHQTRFWDPKMRPYIFGERNKIHIINLEKTLPLYKDALNFAGRLASNGGKILFVGTKRPARELVREHAARCGMPYVDHRWLGGMMTNFRTVKHSIARLKDLETQAEDGTFDKVTKREALALSREREKLDRSLSGIKNMERLPDAMFVVDVGYEHIAISEAKKLGIPVIGVVDTNCSPREVDYVIPGNDDAIRAIELYVSGIADAVIEAKQASSHAAAAGKDDFVEINDTAS
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SDE2_XENTR
Sequence: MASVWVRDALSSRLQLVRVAPGAAALDLLSQAGTAIPLTDFYITCNGHLADLEEKLQDGRTYSIVPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWIKKQADREAEKEQRRLERLQRKLAEPKHYFTDPEYHKQCHDMSERLEEAVIKGLQASSSSMASAESDDTRKRKKDMYSSKGTPGKKKCFWTGLEGLETSSSSDSASDSDLDESPCSSSSSSSDSKYYENIKERLQSPESQSSPEELGQGSSDGSHQMLEGHSSSDRSHQMLEGQASCSGSDQMLEGPSSSAGAQWQSSSKGTELVQESQSIPVESEQNMESQNSSDESKQTAFNNSGINVECENVTSPGSTGQDGQTPNDGVRPASPSIPISKQELQQPSNAETSPIDLLAFKTAAELEALGLEKLKLELGALALKCGGTLQERAARLFSVRGLPRDQIDPSLFAKPAKGKKK
What is the function of this protein?
Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity).  Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity).
What are the official names of this protein?
Splicing regulator SDE2, Replication stress response regulator SDE2.
What is the protein family that this protein belongs to?
Belongs to the SDE2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SFSA_ECOLI
Sequence: MEFSPPLQRATLIQRYKRFLADVITPDGRELTLHCPNTGAMTGCATPGDTVWYSTSDNTKRKYPHTWELTQSQSGAFICVNTLWANRLTKEAILNESISELSGYSSLKSEVKYGAERSRIDFMLQADSRPDCYIEVKSVTLAENEQGYFPDAVTERGQKHLRELMSVAAEGQRAVIFFAVLHSAITRFSPARHIDEKYAQLLSEAQQRGVEILAYKAEISAEGMALKKSLPVTL
What is the function of this protein?
Binds to DNA non-specifically.  Could be a regulatory factor involved in maltose metabolism.
What are the official names of this protein?
Sugar fermentation stimulation protein A.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: DNAG_METJA
Sequence: MIIMDLGTTKYIIYAELIADGYVEKHDVIGAIFGQTEGLLGDELDLRELQKTGRVGRIDVELTNINGKSIAKITVPSSLDRIETSILAATLETIDRVGPCVATVKVIDIEDIRKKKREYIVERAKEILKQLMSNIDVNTIIEEVKESVRMGEIIEYGPERLPAGPAVDSSDDIIVVEGRADVLNLLRCGIKNVIAVEGTSVPKTIIELSKKKIVTVFTDGDRGGELILKELLQVCDVDFVARAPPGKEVEELSKKEIMKCLRSKIPAEHILAQILKDKQKIDEKVCKDEIRNMGIQTIPEIKPEISITSNDDVEVSSVECNPSNNEELPPKYNKYRKFYEKLIELEDSKVLIINGDKEEIVSIEELINNTDNYKSIDAIIINGTVTQKLIDILYEKTNLIFCKDAKIIKKPVNLTLITFGDLNA
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: IRX6_MOUSE
Sequence: MAFSPFGHPYGSTSQFLVSASSSATCCETAPRPVSDVASASTSASTLCCTPYDSRLLGSARPELGAALGIYGAPYAAAQSYPGYLTYGPEPPTLCGALNPQYEFKDAAGSFAPSLTQPGAYYPYETTLGQYQYDRYGGVELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKADSGEDSLGCLNGDTKDATASQEARGLRLSDLEDLEEEEEEEEAEEEAAVSAARRLADFQKSTQPLPAPCAAAQERCLESRECGLGLPRFSFTEAPQSGEADFITAEPGGPTMILHYPSGHKPRIWSLAHTAAASAVESAPSTPPRAQSPECHMIPRQPSSIRRLLVPRDSEGEEDSPAAKAFGNSTFTLQGLPLNCAPYPRRREPEVRFQYPSGAEG
What is the function of this protein?
Transcription factor (PubMed:23172916).  Binds to the IBS motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor (PubMed:23172916).  Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r (PubMed:23172916).  Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells (PubMed:23172916).
What are the official names of this protein?
Iroquois-class homeodomain protein IRX-6, Homeodomain protein IRXB3, Iroquois homeobox protein 6.
What is the protein family that this protein belongs to?
Belongs to the TALE/IRO homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBN_MAIRA
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ACCD_ENDTX
Sequence: MKMTIDNISEKKGVPEGIWTKCKKCDYILLQKDFEENLMVCPKCGYCTRLSARKRIEFTVDKGSFKEMDEAIQPVNFLCFPGYSDKIKKSEMSDAVVTGEAKINGYSVVIAVMDFEFMGGSMGSVVGEKIVRAIEKALKKKRHVIIISASGGARMQEGTISLMQMGKTSAALAKLADNRLAFISILTDPTTGGVAASYAMLGDINIAEPKALIGFAGPRVIEQTIRQQLSEEFQRSEFLEKHGMVDIVVERKNIRDVLTKALTFFYNRQCFLKF
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VAM6_YEAST
Sequence: MLRAQKLHSLKSSDITAILPTEQSQKLVLAKKNGDVEVYSRDGNTLKLFQVYPDLLQNAKNDPLPPVIENFYFANELSTIFAQCKETLILLSTTNLHEYDRIIDRRGINHCWLFERSHKNKEEKNTYLIYSTINTAKMRVLIWEGRTYKNMMEASLSYRKETIRSIYPGETGITLATDLGIYHWPYNKPSLIRIEKTVKNKFPKDMISALTELKEQAEKVIEKKPKKNSHFDAQSFSSMDRMSRKSSMSSLWYRTIRNERGNKIRYTFELDGNDATPMIIDGATKKIFKVELMHNNEEPFLIATDHATFSESNSEFDHMQYLSSNLLMLYNSSTIKFVDYENGFTFLQQKIPEGIKWVKNLSGTYFLVWTSNDEVQLFSYHVDDGSEDDDQESICGDINDPDFYQLWRKVLFYKFFIDSPHSKELCVSDNPEESLDICAMKLRDLTVMWCLRIFDKFQNYMVQLERSRNSRMIRSKCEEMIIKSIFDLFIKFWAPPQLVILKVFPSAISSLVLEITGQEHHCLLKEAEEVKETYDIPPHLLNRWCLPYLTDTRRHLQNLLSKENDDESRITWCYRDREIKQSFDFFLISNHDDVDLNTMLTLIDTVLFKCYLYYNPPMVGPFIRVENHCDSHVIVTELKIRHMFKDLIDFYYKRGNHEEALKFLTDLVDELENDNTDQKQRQKIDHGVKILVIYYLKKLSNPQLDVIFTYTDWLLNRHNDSIKEILSSIFFYDSQACSSRDHLKVYGYIKKFDKLLAIQYLEFAISTFRLEGNKLHTVLIKLYLENLDIPSTRIKLKSLLETTSVYEPRTILKLLNDAIESGSDQLPTNQLNFVKYLKIFPLSKLENHKEAVHILLDEIDDYKAATSYCNDVYQSDSTKGEELLLYLYSKLVSIYDSNRNSKLILNFLQDHGSKLNSAEIYKNLPQDISLYDIGRVVSQLLKKHTSKMDETRLEKALLQVELVATTYKLNERMSSYGVLSDSHKCPICKKVISNFGTDSISWFTREGRNIITHYNCGKVLQERFNAKNEKSSRIKQKTLGEVINELNNK
What is the function of this protein?
Required for vacuolar assembly.  Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion.  HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly.  It remains bound to SNARE complexes after vacuole fusion.
What are the official names of this protein?
Vacuolar morphogenesis protein 6, Vacuolar protein sorting-associated protein 39.
What is the protein family that this protein belongs to?
Belongs to the VAM6/VPS39 family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein.