PharMolix/UniProtQA huggingface dataset:
Protein: ATG35_KOMPG
Sequence: MEEVCSICLEVLVDKEAFTEPCLHYYHNECIKEWTKRANTCPKCRRDYSQIRIGEEVISVKNRSLELHLVDETLEETRERLISYTNLCALCEDPSTSLIYCESCGGSFHFNCIGIGDELDSEWCCPLCGMFQNHLGEASNRNLISATPVGEGRRRVTSIVNTRRTNSIYRSHSNRPAQRAHLMTDSDYTMIVDQHREKLLESQLQESNTQSSGEEESWKLLDEALKSGTQNSQSSEFSTENNVVPLKNTHELGRKLKKPRRASGIKKNVVERSSSHQSTQILKPSSSLISDLLLETRGNSRHPSFTNSTQKLTVEALQSHDPTLKLNIPKTETLSLDQKIVIQKLFIKPRLRNLYDSNTLSKDNYIEINKIICRRLYDKFLQDQLALAYLKQVLEVKERLHGHDLKQFLAQFTHWSELNDFTDDKWQKQETEGSCNHKQTQILSMFDSIIDTMLQNELHKLLT
What is the function of this protein?
Micropexophagy-specific protein required for efficient micropexophagic apparatus (MIPA) formation but not for general autophagy.
What are the official names of this protein?
Autophagy-related protein 36.
Protein: DER_SYNFM
Sequence: MTVVAIVGRPNVGKSTLFNRISKDNSALVDDLPGVTRDRNYARVSWNDKPFVIIDTAGFVGQDTSAFEELTREQILLALDEADILLFVADAKTGLHPGDAELADLLRRSSKPVFYAVNKIDGSEQRRHAAEFFELGLDRIYPISAAHGFGISELMDDLCAAIPEAPAQTAEEEESGGAIRVSILGRPNVGKSTLVNHLLGAPRVIVSPVPGTTRDAVDSHIVKAGQEYVLIDTAGIRRKGRTREKLEKISIIKALQSVERSHVVVLLLDAVEGVTDQDLHIAGYIKERSRACIVGINKWDAADKDPKRTKRFMDDLHDRFRFLTYAPVLTFSALTGRNVARLLPTVKEVFRQYNQRVTTGIVNRALEETLARHEPPQAGNRRRLKFYYATQTAVRPPTFVLFCNYPQAIHFSYERYLTNRFREAFGLDKTPIRLIFRPRQRTGGTS
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: KTHY_SHISS
Sequence: MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVGDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQDKSIHTIDATQPLEAVMDAIRTTVTHWVKELDA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: LGT_HAEI8
Sequence: MNSNYLLLPHFDPSIFTLGDSNIGLRWYGLMYLLGFVFARWLAVRRANRPNSGWTVDQVDTLLFNGFMGVFIGGRVGDVFFYNLDHFLQEPLYLFRVWEGGMSFHGGLIGVIVAMIWTSYSQKRNFWQTADFVAPLIPFGLGLGRIGNFINLELWGRETNVPWAMIFPNDPLLLPRHPSQLYEAFLEGLVLFAILNIFIKKPRPMASVAGLFLIGYGVFRFIVEYVREPEVENFFGIITRGQALCLPMIIGGAFIMAWAYSRKSAVIK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FADB_SHEB5
Sequence: MIYQSPTIQVELLEDNIAKLCFNAPGSVNKFDRETLTSLDAALDSIKQDSNIKALVLTSSKDTFIVGADITEFLGLFAQDDAVLLSWVEQANAVFNKLEDLPFPTASAIKGFALGGGCETILATDFRIADTTAKIGLPETKLGIIPGFGGTVRLPRVIGADNALEWITTGKDQRAEDALKVGAVDAVVAPQALEAAAIQMLKDAVAEKLDWQARRNRKLSALTLPKLEAMMSFTTAKGMVFAVAGKHYPAPMAAVSVIEQASTKGRAEALQIEHQAFIKLAKTDVAKALIGIFLNDQFVKGKAKKAGKLAKEVNNAAVLGAGIMGGGIAYQSASKGTPIVMKDIAQPALDLGLNEAAKLLSAQVARGRSTPEKMAKVLNNITPSLDYAAIKHSDVVVEAVVEHPKIKAQVLAEVEGYVSEDAIIASNTSTISINLLAKSMKKPERFCGMHFFNPVHKMPLVEIIRGEHSSEETIASVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAGFNGLLAEGGDFAAIDKVMEKQFGWPMGPAYLLDVVGLDTGHHAQAVMAEGFPDRMGKSGTDAIDVMFENKRLGQKNGKGFYVYSVDSRGKPKKDVDPTSYGLLKDAFGELKAFEADDIIARTMIPMIIETVRCLEEGIVASPAEADMGLVYGLGFPPFRGGVFRYLDTMGVANFVALADKYAHLGGLYQVTDAMRTLAANNGSYYQA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: COG6_CAEEL
Sequence: MSVIDKTSSAVNPLREKVTTACAKKLYNDKDCIKIADFITPLVEDMNLDSNVDRKLHNKLERYELRLNKEYLSEFEKINNIVQKFDELCVKMNSTCTNLSKQMETVKFKSVDLVQKTASLKEKKASIESRCNMINEFLENYSLSSEELRELDECEQSGHLSEFFFKVLERCHEIRENCRNMVQEQGHLAAFEVMEKMQKIDERSHAIICNNLKREFQNLTVDSHQKKQILSKAFKIISQNDAVFQLAIDQYISSRSQELLNQFVEINKMAVQMPEGLAEPLKAVGDMLTSIHELTEQEKQLFSSICSAENLPIVLDECLKSLTSPFKIRVEQLLSTEKNAITIFKMGNILIFYANKFETLIRKDSYFTIMLADLVKTVRQVCIAGINHHVDGLMRKMTSPHYDLLPVPEVRQCLSLYHGLISIAVKTGDLNLLLEPERIYEYVLEPLIQTVQLSATRLKSDIEVSVFTINCLTVIRSAISEISAFKKKIEMIDAMIEGNSDVLVSVQVSEMLEKSGILELYQKFNAVNPAEKKPLSTLPGLESTTVGEAIVMFTQYLHNHASSDHTYDIDQQILASEERQRIRERNTLEFLKVYKMIVDRLGNPTNGYENLHYLPIEHVESVLKFEKEKENTPSSNESESLA
What is the function of this protein?
Required for normal Golgi function.
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 6, COG complex subunit 6, Component of oligomeric Golgi complex 6.
What is the protein family that this protein belongs to?
Belongs to the COG6 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: ACP_VIBCH
Sequence: MSNIEERVKKIIVEQLGVDEAEVKNESSFVEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDYVTSNAQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSCA_ECOLU
Sequence: MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQGHSVGYDARTNAALDTANTISSVKRLMGRSLADIQQRYPHLPYQFQASENGLPMIETAAGLLNPVRVSADILKALAARATEALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIPDRSDNRVQRELLDAAIAAKIALSDADSVTVNVAGWQGEISREQFNELIAPLVKRTLLACRRVLKDAGVEADEVMEVVMVGGSTRVPLVRERVGEFFGRPPLTSIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPALPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDSEIASMIKDSMSYAEQDVKARMLAEQKVEAARVLESLHGALAADAALLSTAERQVIDDAAAHLSEVAQGDDVDAIEQAIKNVDKQTQDFAARRMDQSVRRALKGHSVDEV
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.  Involved in the maturation of IscU.
What are the official names of this protein?
Chaperone protein HscA, Hsc66.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: NDUC1_PANTR
Sequence: MAPSALLRPLSRLLAPARLPSGPSVRSKFYVREPPNAKPDWLKVGFTLGTTVFLWIYLIKQHNEDILEYKRRNGLE
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial, Complex I-KFYI, CI-KFYI, NADH-ubiquinone oxidoreductase KFYI subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFC1 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: WNT5B_MOUSE
Sequence: MPSLLLVVVAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMSYIGEGAKTGIRECQHQFRQRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRALMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRITRQGKLELANSRFNQPTPEDLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDRFKSVQVERCHCRFHWCCFVRCKKCTEVVDQYVCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.
What are the official names of this protein?
Protein Wnt-5b.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: ALD2_SPOSA
Sequence: MAKIDNAVLPEGSLVLVTGANGFVASHVVEQLLEHGYKVRGTARSASKLANLQKRWDAKYPGRFETAVVEDMLKQGAYDEVIKGAAGVAHIASVVSFSNKYDEVVTPAIGGTLNALRAAAATPSVKRFVLTSSTVSALIPKPNVEGIYLDEKSWNLESIDKAKTLPESDPQKSLWVYAASKTEAELAAWKFMDENKPHFTLNAVLPNYTIGTIFDPETQSGSTSGWMMSLFNGEVSPALALMPPQYYVSAVDIGLLHLGCLVLPQIERRRVYGTAGTFDWNTVLATFRKLYPSKTFPADFPDQGQDLSKFDTAPSLEILKSLGRPGWRSIEESIKDLVGSETA
What is the function of this protein?
Catalyzes the asymmetric reduction of o-substituted aliphatic and aromatic aldehydes and ketones to an S-enantiomer.  Reduces ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate.
What are the official names of this protein?
Aldehyde reductase 2, Aldehyde reductase II, ARII.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: HEM3_MYCBT
Sequence: MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVRH
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: TAGB_DICDI
Sequence: MKFQFSSPSKIFLFSSVILILIFIGIKFELLEDTNSNRNDKFNNIINRFINYNIDDSIYKNKQQQQQFSNKIYSNEKKILLKNKIIDTTIKPSININNNNNNNNKLNNNNNNNNNNNNNNNNNNNNNNNNNNNNYYNSIEYYSSFVSRLLKSNDDDGIYYDDYQSKYKKNHYIVQFKDRINDETREQLKEFLIGTDITILKEQPFKSHIVHYIPHDSFLVFMTKEQSVLLSSKEWISWIGEHEPSNKIHLNYHEKSIGYPVYIILSGSTNSLIQRWENTLNSILTSYNSKVKLTLINQKKLKSIVYCNDESPSSSSSSSCSLIGSEKIVYKWISEQSESNYIERSEKLQTANRLSPTVIFGTKDKLVNNDRIDIPLRGKGQILSIADTGLDGSHCFFSDSKYPIPFNQVNENHRKVVTYITYHDNEDYVNGHGTHVCGSAAGTPEDSSWAISSFSGLATDAKIAFYDLSSGSSEPTPPEDYSQMYKPLYDAGARVHGDSWGSVSLQGYYGGYSDDAGGIDAFLYEYPEFSILRAAGNNELFASLLAQATAKNAITVGAEQTAHVNYVSDALEYYDFSDNANFQRPCLFDKKYCNYTTAKCCSEVSNVKGLQLCCPASIKQNASDSFTTQPQFYNENNMGSFSSKGPTHDGRLKPDIVAPGEYITSARSNGENSTDQCGDGSLPNANGLMSISGTSMATPLATAATTILRQYLVDGYFPTGESVEENKLLPTGSLLKALMINNAQLLNGTYFWSASSTNPSNAIFEQINGANLIQGWGALRMNNWLYVKSSNPTPPSRWIGIGGLGKNQKATEWKEDSLSSGLNKSYCFTYKPSSSSSGSGGGGGTPRIVATLVWTDPPSYSGAKFNLVNNLDLLLLNSDDDSIITIGNSGGSLQPAGKVAQPDTLNNVEGIIINPTKAMNYKFTIAGTNVPIGPQKFSFVFHGENGQFDWADSCPQCVDGVQFPCLITNGIGIQSCGSDLLWTKCIVQSCNEGYNYNSLKNTCDKFLSYNYIIIIVAGGTMVLIILLLMWIKYQEYKESKRDSFRRFDDGTGIFVRPKDKDAKVTPPDLYNLVSPFIIELTIATACSLVATAASILQPFYIGNIVNNIPTTKSIGEFKSDFIIIFILAFIEFLFTNVGSWISGIVNEKMVMRLQNKVFRALIAQDMGFFQRNNSALLMNVLIVDTPMLRSALTGILLSIATGVCKLVGSLVFIFTISWKLSLAFFAAVPILGLVTQIQSQFTKRLTRQLLFHNSKASQHGTESLTNMHVVTNYCKQEKEMVKYSDQLMNVFITARKLIITNTFAGTGKWLLIESLTFVILYFSAYLVIQKQFTVGLMISFSLYIGYVVDASSSLFGVYVSYIQCLASATRVFMILRSAPRKRTTLEEEEADRLAGLSGGGGGGGDNGDDKKDKQNIENGKDVLPSNIITPIDNVENSNGKQDDPNNNNNNIGNLDYSEQLDGVSTVADSTVGLTKRELKKQKEKEQKEYFKQTGISVAETPTFLPSSYTELTECRGEIEFKNVSFRYPTRPDVQVLHNINMKFEAGKCYGLVGPSGSGKSTTLELISKFYPLHGETGGKIYMDGIDIAKIRPNNLRSFVTNVHQHPFLFDATIGENIGYAIDNPTQEDIIEAAKLAYAHEFINDLPKKYDTQIGEAGNLSGGQKKRIAVARAICAKRKIMLLDEITAELDPESEEAITQSIKVLTQGHTVVMVAHKVAAVRDCDKIFVLEKGYLVEEGTHDELMANKGKYYRMFSEDKDDTPLQNNNNNKNNNNNNNNNEPSSSSTPPNDQPTPPPQEQQEQKNDQPPPPPPQEQQEQQEQQQQQQQEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNDQPPNDYDQVPPPPPLPSESPSPPTGNNDGQPLVQMDEENDEER
What is the function of this protein?
Intercellular communication via tagB may mediate integration of cellular differentiation with morphogenesis.
What are the official names of this protein?
Serine protease/ABC transporter B family protein tagB, Prestalk-specific protein tagB.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RR14N_SCHPO
Sequence: MTEVEERINAWNDGFEELLSYIPAKLYYREHTANQWKQKKSTLEEKKERRKMKFSLDGLVNDADDDSQKSSKWEQSSTMSDDTDVSDRHAESMSQIRGKLASKIQDLREKRKAGDLNQKRQNKRPVENEKDSQKGSGKSKVQKKKHKASPRAGF
What is the function of this protein?
Involved in ribosome biogenesis and cell polarity.  Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis (By similarity).
What are the official names of this protein?
Ribosomal RNA-processing protein 14-N, Ribosome biogenesis protein rrp14-N.
What is the protein family that this protein belongs to?
Belongs to the SURF6 family.
Protein: PDXH_LEPCP
Sequence: MKHIADLRKSYESGELDEAFAADTPLLQFDTWLQQALSAGLPEPNAMTVATVSADGRPSTRVVLIKGYDSRGIVWYTNYKSRKGQELAGNPFAALQFHWVTQERVVRIEGRVEKTSAEESDAYYDSRPLDSRLGAWASPQSQPIGSRAVLVANAARTAAQYGLHPPRPPHWGGYRLVPDRWEFWQGRKSRLHDRLVYRLVDGTWLRERLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: Y1080_STAAR
Sequence: MTKYTFKPKDFKAFNVEGLDARMEAVNEYIRPQLHELGEYFSDFFTSQTGETFYPHVAKHARRSVNPPKDTWVAFATSKRGYKMLPHFQIGMFEDQLFVMFGIMHEAKDKATRAKVFERKFKAIQQLPDDYRVCLDHMKPDKPFIKDLTDDDLKEAIQRAINVKKGEFFIARAITPQDKRLKSDKAFIAFLEETFDQFLPFYSA
What are the official names of this protein?
UPF0637 protein SAR1080.
What is the protein family that this protein belongs to?
Belongs to the UPF0637 family.
Protein: METE_BACMK
Sequence: MAIQTSNLGYPRIGLQREWKKTLEAFWSNKIDEEQFLTTMKEIRLQHVKVQQEKGIELIPVGDFTYYDHVLDTAYMLGFIPSRFSEFTSYLDVYFAMARGSKDHVASEMTKWFNTNYHYIVPEYEEGLQISLKDNRPLRLYEEAKKELGVDGKPVILGPYTFLKLAKGYNEEQFATILKELVAPYVQLFSELHAAGAQIIQVDEPIFASLTKDEINQAKELYEAIHKEVPNANLLLQTYFDSVEENYEEIIAFPVSGIGLDFVHGKEGNVNAISKYGFPADKILAIGCIDGRNIWRADLDDVLSLFTTLQNQITAKGLIVQPSCSLLHTPIDKTEETHLTSELFDALAFANQKLEELVLIHSALTKGVESISSDLTTYRNAHHAIRSSAARNREDVKVARTSLKEDDFSRPLPFEKRYELQQVALQLPLLPTTTIGSFPQTSEVRQTRKQWRNGDITNEQYNQFIEKETAKWIRYQEDIGLDVLVHGEFERTDMVEYFGERLAGFSFTKNGWVQSYGSRCVKPPVIYGDVAFISGMTIKETVYAQSLTEKVVKGMLTGPVTILNWSFVRNDISRKEVSYQIALALRHEIELLESSGIRVIQVDEPALREGMPLKEKDWDAYITWAVQSFLLATSSVENETQIHTHMCYSNFEDIVDAIRALDADVISIETSRSHGEFINTLKHTTYEKGIGLGVYDIHSPRVPSKDEMFTIVEQSLQVCDPKYFWINPDCGLKTRRTEEVIPALEHMVQAAKDARSLLKTNA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: GNT1_ASPFU
Sequence: MGNKKATLLPYRRDSASSEADFFDIPDEPCLAIAKRQLRRIRTWIFFAVFIILILWFRREAPSPAPVSHIDYNKVDWSRYAYSQYATSSAYLCNAVMVFEALERLGSRADRVLFYPEDWDLFVADDHDRDSQLLVLAKEKYKALLVPISAEMIKAGGGSGESWDKSIAKLLAFGETEYDRVIHIDSDVTVLQSMDELFFLPPAKVAMPRAYWALPDTKTLSSLLIVIEPSYREFKALMESAQPALHGQVEVDSNETQRYDMELLNNRYADSALVLPHRQYGLVTGEFRKKDHRSFFGNDYETWDPDKVLAEAKLVHFSDWPLPKPWVLSNQKLLAEILPKCDFKPGTMQERGCRDREVWKSLYEDFRRRRKVCPKIRTIHTEYG
What is the function of this protein?
N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.
What are the official names of this protein?
Glucose N-acetyltransferase 1, N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GNT1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein. Vacuole membrane; Single-pass type II membrane protein.
Protein: VIRB8_BRUA2
Sequence: MFGRKQSPQKSVKNGQGNAPSVYDEALNWEAAHVRLVEKSERRAWKIAGAFGTITVLLGIGIAGMLPLKQHVPYLVRVNAQTGAPDILTSLDEKSVSYDTVMDKYWLSQYVIARETYDWYTLQKDYETVGMLSSPSEGQSYASQFQGDKALDKQYGSNVRTSVTIVSIVPNGKGIGTVRFAKTTKRTNETGDGETTHWIATIGYQYVNPSLMSESARLTNPLGFNVTSYRVDPEMGVVQ
What is the function of this protein?
The virB operon is essential for intracellular survival and is not involved in the invasion process.  Constitutes a major determinant of virulence in mice.
What are the official names of this protein?
Type IV secretion system protein virB8.
What is the protein family that this protein belongs to?
Belongs to the virB8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SLMA_HAEIG
Sequence: MVEEQLSLSGVEEIAPKIETPKIEKRTVKERRQQVLTVLIHMLHSERGMERMTTARLAKEVGVSEAALYRYFPSKTKMFEALIEHIESTLLSRITASMRNETQTMNRIHDILQTILDFARKNPGLTRVLTGHALMFEEAQLQARVAQFFDRLEMQFVNILQMRKLREGRAFNVDERIIASHLVTLCEGQFMRYVRTNFRLNSSQSFEQQWRFIEPLFA
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: VAPB5_METJA
Sequence: MQGPVIIPLISTLGLSFLAILLAYKISFSVIGFINSTLPTTLFPSKPYMLFVKISTISPLTCPSLIILTPALTWSLTALSMAYLYSSYKPNTFFTLSKNVSSFLTTG
What is the function of this protein?
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.  Its cognate toxin is VapC5 (Potential).
What are the official names of this protein?
Putative antitoxin VapB5.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM2_CANGA
Sequence: MHTADFLDIEPTEISSILSGGYNHPLLREWQSERQLKKNMLIFPLFISDIPDEATPIDSLPNIKRFGINKLVDYVKPLVEKGLRSVILFGVPLKEGTKDPVGTAADDPEGPVIQAIKLLRKEFPELYIICDVCLCEYTSHGHCGVLYDDGTINRERSVSRIAAVAVNYAKAGAHCVAPSDMIDGRIKDIKKGLISAGLAHKTFVLSYAAKFSGNLYGPFRDAACSSPSNGDRKCYQLPQAGRGLARRALARDKNEGADGIIVKPSTFYLDIMRDASEICEDLPICAYHVSGEYAMLHAAAEKGIVDLKSIAFESHEGFLRAGARLIISYFTPEFLDWLSN
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: LPXL_HAEIN
Sequence: MKNEKLPQFQPHFLAPKYWLFWLGVAIWRSILCLPYPILRHIGHGFGWLFSHLKVGERRAAIARRNLELCFPDMPENEREVILQENLRSVGMAIIETGMAWFWSDSRIKKWSKVEGLHYLKENQKDGIVLVGVHFLTLELGARIIGLHHPGIGVYRPNDNPLLDWLQTQGRLRSNKDMLDRKDLRGMIKALRHEETIWYAPDHDYGRKNAVFVPFFAVPDTCTTTGSYYLLKSSQNSKVIPFAPLRNKDGSGYTVSISAPVDFTDLQDETAIAARMNQIVEKEIMKDITIYMWLHRRFKTRPDEKTPSLYD
What is the function of this protein?
Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-lipid IV(A) to form a Kdo(2)-(acyl)-lipid IV(A).
What are the official names of this protein?
Lipid A biosynthesis acyltransferase, Kdo(2)-lipid IV(A) acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LpxL/LpxM/LpxP family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RPOZ_BURTA
Sequence: MARITVEDCLKQIPNRFELALAATYRARQLAQGHTPKIESRDKPTVVALREIAAGQVGVEMLKKVPV
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: TRUA_METMP
Sequence: MYIFKIAYDGKLSFQTQPHGETVCDKISNALLDCGYLDNKDRVPLYHGGRTDRGVAALGNYVVYEMDKKPVLPRVQSKLKWDGIWVLGCKKIEIFPEIEHRHYQYTLPNKNHDVELMKKASEKLIGTHYFQNLSKRDKTKVKDPVRTLYDIKISSNDYFITIDIFGESFLWNMVRRIIRLLSDIGKHKIENPEKFIELILSEDYKKGYPPSPAEGLILVDVKTNIDIDLDSYVIRNLKNSWEKSLNNSLMRLGLCKTVLSKT
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: VPS11_HUMAN
Sequence: MAAYLQWRRFVFFDKELVKEPLSNDGAAPGATPASGSAASKFLCLPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLCTRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGNYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIAHWFRGYLIIVSRDRKVSPKSEFTSRDSQSSDKQILNIYDLCNKFIAYSTVFEDVVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKKKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKILMHHIPEQTTQLLKGLCTDYRPSLEGRSDREAPGCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQVKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVISVCERHGEQDPSLWEQALSYFARKEEDCKEYVAAVLKHIENKNLMPPLLVVQTLAHNSTATLSVIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLRCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTSSLEAGLQRDLLMHSRRGT
What is the function of this protein?
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways.  Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion.  The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes.  The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203).  Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203).  Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287).  Involved in the retrograde Shiga toxin transport (PubMed:23593995).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 11 homolog, hVPS11, RING finger protein 108.
What is the protein family that this protein belongs to?
Belongs to the VPS11 family.
What are the subcellular locations of this protein?
Endosome. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.