PharMolix/UniProtQA huggingface dataset:
Protein: FLGI_METFK
Sequence: MTLTRPLALISALAALILALPADAERIKDLTTIQGVRSNQLIGYGLVVGLDGTGDQTTQTPFTVQSIVSMMQQMGINLPSGTNLQLRNVAAVMVTGNLPPFAQPGQPMDVTVSSMGNARSLRGGTLLMTPLKGADNQVYAMAQGNLVIGGAGAGASGTSTQINHLGAGRISAGAIVERAVPSQLTETSTIRLELKEADFSTASMVVDAINKRFGNGTATPLDGRVIQVQPPMDINRIAFIGNLENLDVKPSQGPAKVILNARTGSVVMNQAVTLDDCAISHGNLSVVINTAPAISQPGPFSGGQTVATQVSQVEINKEPGQVIKLDKGTSLADVVKALNAIGATPQDLVAILQAMKAAGSLRADLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: YIDH_ECOLI
Sequence: MKISRLGEAPDYRFSLANERTFLAWIRTALGFLAAGVGLDQLAPDFATPVIRELLALLLCLFSGGLAMYGYLRWLRNEKAMRLKEDLPYTNSLLIISLILMVVAVIVMGLVLYAG
What are the official names of this protein?
Inner membrane protein YidH.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv2272.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYB_CYACH
Sequence: MALNLRKNHPLMKIINDSLIDLPTPSNISAWWYFGYFLGICLITQIITGLLLAMHYTADTSYAFTSVAHMCRNVQFGWLIRNLHANGASLFFVCIYLHIGRGLYYGSYLNKETWNIGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWLWGGFSVDNPTLTRFFAFHFLLPFVIVGMTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYSIKDLLGFALMLILLVTLALFNPNLLGDPENFTPANPLATPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLIPLLHVSKQRSMTFRPLSQILFWTLVADLLILTWVGSQPVEHPFIIIGQLASLAYFTIILILFPIASALENKMLNL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL18_CAMHC
Sequence: MTANTLKRKISLRIKRKRKIRANISGSAVCPRISIFKSNRTIYAQAIDDTNSKTLCASSGTALKIKANKDGAAILAKDFAEKLKAAKISEAIFDRNGYLYHGVVAAFADALRKNGIKL
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ARL3_PIG
Sequence: MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWRNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK
What is the function of this protein?
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).  Required for normal cytokinesis and cilia signaling.  Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms.  Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E.  Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity).  Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Note=Detected predominantly in the photoreceptor connecting cilium. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. Present on the mitotic spindle (By similarity).
Protein: Y999_CAMJE
Sequence: MKTSFLAHSVAIVRSNFKGLLFTACIVIFAMYLSSVQSIKDTTHLAATAFAIIIGVLLSPWFFKYQHHFQAGVHFSAKKLLRLGIVLYGFNITLTELLSVGLKGFLLSAIVIFFVFIIALFVGTKIFKLDKETSMLVGAGSAICGAAAVLALESSLKSDPFKGILAVGTVVIFGLVFMFLYPIAFSLNLFPFFDQNAMGVFMGATLHEVANVAGAAEMAKDMAGFEQGASNVAVIIKMMRVILLVPFLLIVTYFFAKNQHSSSGKTAKSITIPYFAFAFLGMIVLNTYLASKESILGIATSDIISLGKTLCTLCIVFAMAALGLQIDFKKFLKSGSRVFGLAFVLGLVLIFGGYFLTLAFKGILW
What are the official names of this protein?
UPF0324 membrane protein Cj0999c.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CNBP1_HUMAN
Sequence: MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ
What is the function of this protein?
Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
What are the official names of this protein?
Beta-catenin-interacting protein 1, Inhibitor of beta-catenin and Tcf-4.
What is the protein family that this protein belongs to?
Belongs to the CTNNBIP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CAPP_METEA
Sequence: MTKTLHARPSAATDTTFAPPVITGTATEDALEILFHALLDVARRHDPELEDVLHGRADISSFTPEMLARALQVQGIWFQLVSIAEQNAAMRRRRHVERDQGREALNGSFAKVLAEASARGIGPQQIHALLKDLRIRPTITAHPTEGKRVTVLEKLRRIYLVLRELELPRWTERERNGLMNELRDQIELIWMTGELHLEKATVEREVAWGLHFFDETLFEMLPEMLLSLEESLAQYYPDETFEVPPFFQFGSWIGGDRDGNPYVTASVTRETLQRNALASLRRYRDGITHLGRVLSITERSLPVPETFRSELAHMLAESGDARAIANRNPGEAYRQFLSCVLRKLEATIARNKGARSVGPDYPSADGLINDLRTLEKGLADAKCGALATDIVRPVRRMVEIFRFSTVRLDLRENSTRTTKTLHALWKLRNGDREPPALDSPAWKDWLLTELARPRTPETSFEDFADRLPDDARETLATFALVGEMRDTLDREAFGAFILSMTRSTVDVLGAYLLAKEAGIFLDTTGTEICPLPIVPLFETIDDLRAAPAIMKELLGIPVVRRSTRWQGGVQEVMIGYSDSNKDGGFIASNWELYKAQVRLTTLGNHLGVPIAFFHGRGGSVSRGGVPTHRGIAAQPPGSIQGRFRITEQGEVVSFKYANRGTAAYQMELLAASVFEHALLSEGNGNGSRAEFDDALEALSGASRAAYVNLLQAEGLVDYFQAASPLDEISLLNIGSRPARRFGAKSLSDLRAIPWVFAWSQNRHVITGWYGVGSGLKSFIDVRGEAGEALLRRLFRDCRVFRLVLDEVEKTLLMVDLEIARDYAGLVEDAGIRARIFGMIEAEYALTREMVLRVSGDSELAQRFPQFSERLRGRLPTINQVSREQVELLRRYRSETDEDKREAVKSALLLSINCIAVGFGATG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: RSMB_VIBVU
Sequence: MNVRAAAANVLYQVVDRGNSLSTALPEAQQSIRPRDHALLQEICYGALRYLPRLESIAGKLMDKPLKGKQRVFHHLILVGLYQLGHMRIPAHAAVGETVEGAQALKGPRLRGLINAVLRNYQREQQALDEFSVSHNAGKYVHPSWLLKILQDAYPEQWQTIVEANNNKAPMWLRVNHAHHDRDEYLQLLKNANIDSTLHSEAMDAIKLAAPCDVHSLPGFEQGWVSVQDAAAQLSFNYLQPKDGELILDCCAAPGGKTAHILERVSAREVVALDCDEQRLKRVTENLKRLNLQAKVICGDARNPEQWWQGEQFDRILLDAPCSATGVIRRHPDIKWLRRAEDITALAQLQSEIFDAMWAQLKPGGTLVYATCSITPMENVEQVKAFLARTSAAQLVGSERENPGRQIIPGEEDMDGFYYAVLVKQA
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNY_STRR6
Sequence: MSLAIAVFAVIIGLVIGYVSISAKMKSSQEAAELMLLNAEQEATNLRGQAEREADLLVNEAKRESKSLKKEALLEAKEEARKYREEVDAEFKSERQELKQIESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAELERIGALSQAEARDIILAQTEENLTREIASRIREAEQEVKERSDKMAKDILVQAMQRIAGEYVAESTNSTVHLPDDTMKGRIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFDPIRREIARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEAAAYEIGAPNLHPDLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAIDHEVEGSHVEIGMELARKYKEPPVVVNTIASHHGDVEAESVIAVIVAAADALSAARPGARSESLESYIKRLHDLEEIANGFEGVQTSFALQAGREIRIMVNPGKIKDDKVTILAHKVRKKIENNLDYPGNIKVTVIRELRAVDYAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: NUON_MOOTA
Sequence: MANLHLLTVEILTAALGLGLLALGLLVPHSDRRGIAYVATAGLAGILAAAFGMREASGVVLGGYVIDPFGTYFKILFLVAAMLTAACSYDYVEKMGLNQGEYYALLVLATLGMMVLASSGELVSLYLGLELMTITFCILAAFHLGDAKSAEAGIKYVLLGAMSSAIFLYGLSLVYGSSGTTVIREIGQAVATRGASPALLLGTIFILAGFAFKVTAVPFHMWSPDVYEGAPTPVTGFLSVASKAAAFAALVRVFFGALPDLHSFWVQLFIALAVLTIVLGNLVAIPQTNIKRLLAYSSIAQAGYLLLGIVSFSVLGVGAVMYYAMLYVFGNMGAFMAATAFYNNDGSDEIKDYAGLARRSPLVAALMLFSLLSLAGIPPMAGFVGKFYLFMSIISRQYIWLAILGILMSMVSVYYYLLVAKAMYLGNPPEGSKPLRVAPGLQVAMVVSLLILFILGIYPTPLTNYAMNSAVTFFMP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LIMS1_MOUSE
Sequence: MANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVSCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLSETLGRK
What is the function of this protein?
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.  Involved in the regulation of cell survival, cell proliferation and cell differentiation.
What are the official names of this protein?
LIM and senescent cell antigen-like-containing domain protein 1, Particularly interesting new Cys-His protein 1, PINCH-1.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MUTS_FLAPJ
Sequence: MSTKEIKETPLMKQYNEIKRKYPDACLLFRVGDFYETFGDDAVRASKILGITLTKRGAGSPTETALAGFPHHSINTYLPKLVKAGLRVAICDQLEDPKMTKTIVKRGVTELVTPGVSMNDEVLNSKTNNFLASIYFGKKIIGVSFLDVSTGEFLTSEGNEEYIDKLLQNFSPSEILVPKQNKGDFKEKFGDNFHAFYLEDWVYKEDYATETLTNHFQTNSLKGFGIEELASGIIASGAILYYLSETQHNKIQHITSIHRIAEDAYVWMDRFTIRNLELYHSYNPNAVTLLDIIDKTLSPMGGRMLKRWLALPLKNATIIKSRHEVVAYFKDHQEILQKVQNQIKQISDLERLISKVAAGRISPREIIYLKESLDAIIPIKELALKSPQEAVKVIGDSLHSCDLLREKIKTTLNQEAPVAISKGNAIAAGIHPELDELRGISALGKEYLEGIEKRESEKTGISSLKISFNNVFGYYIEVRNTHKDKVPTEWIRKQTLVNAERYITEELKEYETKILGAEEKIQQIENQLFEQLVSWIATYIKPVQLNANLIAQLDCLISFTQLAIDNKYVCPQINDSFALDIKNGRHPVIEKQLPIGVPYIANDVYLDRDTQQLIMITGPNMSGKSAILRQTALIVLLAQMGSFVPAESVQMGIVDKIFTRVGASDNISMGESTFMVEMNETASILNNISDRSLVLLDEIGRGTSTYDGVSIAWAIAEFLHENPAQPKTLFATHYHELNEMTESLPRIQNYNVSVKELKDTVLFIRKLVKGGSAHSFGIHVAKMAGMPQIVLQKAEKILKKLEKNHSAEALSGTKGNKDDIQLSIFNLDDPLLEEIKEEILNLDINTLTPVEALMKLNEIKRMLSKK
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: THII_STRP3
Sequence: MDYSEIMVRHGELSTKGKNRMRFINKLKNNIQDVLAPFPAITVRSDRDRTHVSLNGTDYQPIVEALKLVFGVQALSPVYKLEKSVPLLVTAVQDIMTSLYRDGLTFKIATKRSDHAFELDSRELNSLLGGAVFEVLPNIQAQMKHPDVTLKVEIRDEAAYISYEEIKGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGLDIEVVHFASPPYTSPGALAKAQDLTRRLTRFGGNIQFIEVPFTEIQEEIKNKAPEAYLMTLTRRFMMRITDAIREQRKGLVIVNGESLGQVASQTLESMQAINAVTSTPIIRPVVTMDKLEIIEMAQAIDTFDISIQPFEDCCTIFAPDRPKTNPKLGNAEKYEERFDIDGLVQRAVSGIVVTEITPEIVNDEVENLIDALL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DID6A_ECHCS
Sequence: MIQVLLVIICLAVFPYQGSSIILESGNINDYEIVYPKKVAVLPTGAMNSVHPCCDPVTCEPREGEHCISGPCCRNCKFLNAGTICKKAMLDGLNDYCTGISSDCPRNRYKGKEDD
What is the function of this protein?
Potently inhibits adhesion of alpha-4/beta-1 (ITGA4/ITGB1) and alpha-9/beta-1 (ITGA9/ITGB1) integrins to VCAM1, and adhesion of alpha-5/beta-1 (ITGA5/ITGB1) integrin to fibronectin.  Has a much less effect on alpha-IIb/beta-3 (ITGA2B/ITGB3) integrin.  Also potently inhibits neutrophil migration across TNF-alpha-activated human umbilical endothelial cells.
What are the official names of this protein?
Disintegrin EC6 subunit alpha, EC6A.
What is the protein family that this protein belongs to?
Belongs to the disintegrin family. Dimeric disintegrin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RRF_TOLAT
Sequence: MINEIKTDAKDRMTKSVDSLKSHMSKIRTGRAQPALLDGIMVEYYGSATPLRQVANVVAEDSRTLAVSVFDRSMIQAVEKAIMTSDLGLNPSSAGTTIRVPLPALTEERRKDLIKLVRAEAEQARVSVRNVRRDCNADLKALLKDKDISEDDDRRAQEEIQKLTDSFVKLVDDLLAAKEKELMEI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGRP3_MOUSE
Sequence: MLVSWDHPKMLPRLLGFLALSLLACGNPTIVSRKEWGASSLTCRVPLSLPVPYLIIEQVTRMQCQDQITCSQVVRVLQSQYVHNKGWCDIAFNFLVGDDGKVYEGVGWYVQGLHTQGYNNVSLGIAFFGSKIGSPSPAALSATEDLIFFAIQNGYLSPKYIQPFLLKEETCLVPQHSEIPKKACPNITPRSAWEARETHCPQMNLPAKFVIIIHTAGKSCNESADCLVRVRDTQSFHIDNQDFCDIAYHFLVGQDGEVYEGVGWNIEGSHTYGYNDIALGIAFMGNFVEKPPNEASLKAAQSLIQCAVAKGYLTSNYLLMGHSDVSNILSPGQALYNIIKTWPHFKH
What is the function of this protein?
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria.  Has bactericidal activity towards Gram-positive bacteria.  May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis.  Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria.  Plays a role in innate immunity (By similarity).
What are the official names of this protein?
Peptidoglycan recognition protein 3, Peptidoglycan recognition protein I-alpha, PGLYRPIalpha, PGRP-I-alpha, Peptidoglycan recognition protein intermediate alpha.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAT_BUCAP
Sequence: MKILVSKKITLDLFCKNPIQIIEKEKNEIISISKNKKTVFYVIQPKALKKLFDIKEYFVKSKITKKEKKIIEKFPMHTNWIPDKDFIQKAALWGISLNEEVSKYELASFISYWEAEGLFFHHIQWQQKLARSLERSRSMNNAIQQKKDITYIPVPDQKTPDGFRGK
What is the function of this protein?
This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response.  It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity).
What are the official names of this protein?
Primosomal protein 1, Primosomal protein I.
What is the protein family that this protein belongs to?
Belongs to the DnaT family.
Protein: ULAG_ECO81
Sequence: MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGANVCVDFWCGTGKQSHGNPLMKQGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPKTCVDLWIGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPDGMDDRAVNYLFKTPGGTLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADILRMGEALNAKVVIPFHHDIWSNFQADPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL
What is the function of this protein?
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P.  Is essential for L-ascorbate utilization under anaerobic conditions.
What are the official names of this protein?
Probable L-ascorbate-6-phosphate lactonase UlaG, L-ascorbate utilization protein G.
What is the protein family that this protein belongs to?
Belongs to the UlaG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP11A_HORSE
Sequence: MLVRGLPLRSVLVKGCQPLLSAPREGPGHPRVPTGEGAGMSSHSPRPFKEIPSPGDNGWINLYHFWREKGPKKLHYHHFQNFQKYGPIYREKLGNVESVYIVDPEDVALLFKFEGPHPERFLIPPWTAYHQYFQKPVGVLFKSSDAWKKDRLALNPEVMALESIKNFIPLLDPVSQDFVSLLHRRMEQQGSGKFSGPIIEDLFRFAFESITNVIFGERQGMLDEIVDPEAQRFIDAVYKMFHTSVPMLSLPPDLFRLFRTKTWRDHVAAWDTVFSKAEQYTEKFYQDLKQKRHFDSYPGIFYRLLASNKLPFKDIQANVTEMLAGGVDTTSMSLQWHLYEIARNLRVQEMLREEVLAARRQAQGDTSTMVQMVPLLKASIKETLRLHPIAVTLQRYPQNDLVIRDYMIPAKTLVQVSIYTMGQDPTFFSNPRRFDPTRWLDKNKDLTHFRNLGFGWGVRQCLGRRIAELEMTLFLIHILENFRVEIQHLNDVDSTFGLILIPEKPISFTFWPITRAPPQA
What is the function of this protein?
A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones.  Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule.  Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
What are the official names of this protein?
Cholesterol side-chain cleavage enzyme, mitochondrial, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc).
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Protein: GFA_RHOP5
Sequence: MTVHIHPAVDNGVKKGTGSFAGGTLVCKCSDRPVKVGIKGDVAHNHACGCTKCWKPDGATFSVVAVVPRGNVTVLENGDKLQIVDTSATIQRHACKVCGTHMFGRIENTGHPFYGLDFIHPELFYEQGSAAPEFAAFVSSIIESGVDPAQMPEIRSRLKELGLEPYDCLSPALMDAIAGHIAKTSRKAA
What is the function of this protein?
Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.
What are the official names of this protein?
Glutathione-dependent formaldehyde-activating enzyme, S-(hydroxymethyl)glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the Gfa family.
Protein: DPO4_SYMTH
Sequence: MRTDLWVIHLDMDAFFASIEQRDNPRLRGKPVIVGGSPNSRGVVSTCSYEARRFGVRSAMPSREALRLCPQAVFIRPNHAKYAAVGRQVRAIMRRFTDVIEPLSIDEAFLDVSGQDAVRVARELKEAIRAELHLTGSAGVSYCKFLAKLASDMQKPDGLTVITWERAQELLPTLPVRKLWGVGPASEQALHALGIYTCGDLLAYDPDTLRKHFGKRADELILLARGIDPRPVVPYREAKSIGEENTFPVDQTDREYLSRLLERYADNLAEELRRQGLYARTVTVKIKWNVFVEGGPKGGDFLQITRSQTLPMPTNDARTIGRVAREIFARVEWEGRKVRLLGLSVHNLVKQGEQVQAYLPI
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATP_SALEP
Sequence: MKYQQLENLESGWKWKYLVKKHREGELITRYVEASAAQEAVNLLLALENEPVRVNVWIDRHMNPALLNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFMVWQRLAGLAQRRGKTLSETIVQLIEDAEHKEKYATQMTTLKQDLQALLGKK
What is the function of this protein?
Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle.  Prevents early segregation of duplicated Ter macrodomains during cell division.  Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
What are the official names of this protein?
Macrodomain Ter protein.
What is the protein family that this protein belongs to?
Belongs to the MatP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_DESOH
Sequence: MDRIIVEGGRRLTGTVEISGAKNAALPILASSLLTNGTCTYTNVPDLRDIQSIKELLTHLGAKIECQGTTVQVDASGVNNHEAPYELVRKMRASILVLCPLVARLGRARVSLPGGCAIGERPIDFHLKGLEAMGADIALEHGYVNASAPKLTGGSIYFDVPSVTGTENLLMAAALADGTTRIGNAACEPEVTALVDVLNQMGANITGAGTPEITIQGVPSLNPVSVSIIPDRIETGTFMVAAALTKGDITITNAEPSHLKGQLDKLAQTGARIEVNGKVIRVVGGDTIKSVDVKTLPYPGFPTDMQAQFMVLMSVASGLSIITETIFENRFIHVSELKRMGADITISGNTAMVAGAPKLSGAPVMASDLRASASLVLAGLVADGTTEISRVYHLDRGYENLEEKFERLGASIRRVTP
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_CALS8
Sequence: MAEFELEVLQPERIFFKDKVEMIVVRAIDGEIGIMAGHEPIVTPIGIGKLRIKKGGKWREAAIAGGILEVNQNKVVILSDAVEWPEEIDRQRALAAKERAEKKLQQKLPPDEFERYQAALYRAINRLRMIEERRNGD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.