PharMolix/UniProtQA huggingface dataset:
Protein: TRMD_ACTSZ
Sequence: MFIGIVTLFPEMFKAITEFGVTGRAVKQNLLQVRCYNPRDFTHDKHKTVDDRPYGGGPGMLMMVQPLRDAIHSAKAEAGEGVKVIYLSPQGRKLEQSGVTELAQNKKLILVCGRYEGIDERLIQTEVDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASADEDSFAAGLLDCPHYTRPEELDGLTVPPVLMSGNHEQIRKWRLTQSLERTWLRRPELLEKLALTDEQKKILNQIKSETV
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSTT_CAMFF
Sequence: MGMFTKLTKSYTDGNLIIQILIGITIGGILGFIAHKSSVEAAIVVNAASMLGNLFVGALKAVAPILVFILVASSIIIKEFGQANGLKNIIILYLVGTFLASLSAVVVSFIFPTTLVLQNTSNALASAPQSIIVVLKDLVFKMVDNPVHAISSGNYIGILTWAIGTGIALRHSSIETKKIFKDISEGITRIVKFIIKLAPFGIFGLVATSVAEAGFEAIGGYAKLLLVLVGTMLFVAFVVNAAIVYFVTKQNPYPLIMTCIKESAVTAFFTRSSAANIPVNMSLCKKLNLDEKLYSISIPLGATINMAGAAVTIAVLSLSAVNTLNIQVGFLDALLLSIIAAIGACGASGVAGGSLMLIPLACSLFGISNDIAMQVVAVGFIIGVVQDSIETALNSSTDVLFTAIASQKS
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEE_SYNY3
Sequence: MSMGPISELLTVSYPIAETFHSLQGEGAWAGGNAFFIRLGGCDVHCPWCDQKETWPTQHHPRQTVTELVQQAVTAKPSFVVITGGEPLMHDLQPLCKTLKNQGLRLHLETSGAYPLTGQFDWITLSPKPYKLPQAAIYPLANELKVIISQDEDFDWAEMEARKISPGTPLYLQAEWETEAMNEKIFAYILTHSQWRLSLQTHKYLGVR
What is the function of this protein?
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
What are the official names of this protein?
7-carboxy-7-deazaguanine synthase, CDG synthase, Queuosine biosynthesis protein QueE.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
Protein: LEG1_RAT
Sequence: MACGLVASNLNLKPGECLKVRGELAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDDGTWGTEQRETAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE
What is the function of this protein?
Lectin that binds beta-galactoside and a wide array of complex carbohydrates.  Plays a role in regulating apoptosis, cell proliferation and cell differentiation.  Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.  Strong inducer of T-cell apoptosis.
What are the official names of this protein?
Galectin-1, Gal-1, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, RL 14.5, S-Lac lectin 1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Cytoplasm. Secreted. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: HMCES_MOUSE
Sequence: MCGRTSCHLPREVLTRACAYQDRQGRRRLPQWRDPDKYCPSYNKSPQSSSPVLLSRLHFEKDADSSDRIIIPMRWGLVPSWFKESDPSKLQFNTTNCRSDTIMEKQSFKVPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQIKTEKSGGNDASDSSDNKEKVWDNWRLLTMAGIFDCWEAPGGECLYSYSIITVDSCRGLSDIHSRMPAILDGEEAVSKWLDFGEVATQEALKLIHPIDNITFHPVSPVVNNSRNNTPECLAPADLLVKKEPKANGSSQRMMQWLATKSPKKEVPDSPKKDASGLPQWSSQFLQKSPLPAKRGATSSFLDRWLKQEKEDEPMAKKPNS
What is the function of this protein?
Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (By similarity).  Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (By similarity).  The HMCES DNA-protein cross-link is then degraded by the proteasome (By similarity).  Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (By similarity).  Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity).  Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (PubMed:31806351).  Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (PubMed:29020633).
What are the official names of this protein?
Abasic site processing protein HMCES, Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, Peptidase HMCES, SRAP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOS response-associated peptidase family.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited to chromatin following DNA damage. Localizes to replication forks.
Protein: PSRP_ACIB5
Sequence: MSESKQFKRSVFFISDGTAITAETLGHSLLAQFPNVDFDIHIMPYITTEEAAMAVVVEINKCQTRDGCLPLVFDTLVDPHVREIINTAKAVNLDVFEGLISKLEQELGTPPTTLVGQTHAVTDSEYYKARIDAVHFALDNDDGARTRHYDKADLILIGVSRSGKTPTSIYLSLQFGIRVANYPLTEEDLDDNRLPAVLREHRSKLFGLMIDAERLVAIRSERKANSRYASFSQCQMELRAIEGIYISEGIKYLNVTEMSIEEISTRILQMTGLKRRIG
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: GPPA_ECODH
Sequence: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: PSD_BRUME
Sequence: MSLTDTIRNTFVPIHREGYPFIAGFFVVSLMLGWLWDPLFWIGMVLTVWCIYFYRDPERVTPMDDDLVISPADGKVSFVGLAVPPAELDLGYEPMTRVSVFMNVFSVHINRSPVRGKIDKVVHRPGKFLNAELDKASTENERNSVLIESPHGKIGVVQIAGLVARRIVCWSNQDDELSVGERFGLIRFGSRVDVYLPSDATVRVAVGQTAIAGETVLADYGTERGEPVVRIA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MNTP_HALH5
Sequence: MVEELIALLIMASALGMDAFSIALGMGTLGLRFSQMFKVGLTIGVFHVIMPLMGMVAGKLLSAHLGLFANWLGAGLLLWLGLVMIVSPFQEKERTFVDPSGIGLFVFALSVSLDSLSAGLSLGMVGAKMALAVVAMGVMSTVLSWLGLFIGMRFQRYVGPYSELLGGFILCGFGVKLLLPY
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
Protein: STAD_OLEEU
Sequence: MALKLCFPPHKMPSFPDARIRSHRVFMASTIHSPSMEVGKVKKPFTPPREVHVQVTHSLAPEKREIFNSLNNWAQENILVLLKDVDKCWQPSDFLPDSASEGFDEQVMELRKRCKEIPDDYFIVLVGDMITEEALPTYQTMLNTLDGVRDETGASLTPWAIWTRAWTAEENRHGDLLNKYLYLSGRVDMKQIEKTIQYLIGSGMDPRTENNPYLGFIYTSFQERATFISHGNTARLAKEHGDLKLAQICGIIAADEKRHETAYTKIVEKLFEIDPDGTVLALADMMRKKVSMPAHLMYDGQDDNLFENFSSVAQRLGVYTAKDYADILEFLVGRWDIEKLTGLSGEGRKAQDYVCTLPPRIRRLEERAQSRVKKASATPFSWIFGREINL
What is the function of this protein?
Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain.
What are the official names of this protein?
Stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic, Stearoyl-ACP desaturase, Acyl-[acyl-carrier-protein] desaturase.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid. Note=In green tissue, found in chloroplasts. In non-photosynthetic tissue, found in plastids.
Protein: DEF_WOLTR
Sequence: MPKLSIVVAPDERLTTRASEVTGINDKIKELVNDMFETMYNAEGLGLAAVQIGVLKRIFVMDIQLEDIKGEPVGYESTGKFCMINPEITELSDEQVILKEGCLSIPEQSHEIRRPKYLTVKYKDLNNKEQTLKASGWLARCIQHELDHLNGILYIRHLSKLKYDMAMKKAEKFKRHYER
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: LS14A_HUMAN
Sequence: MSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQDTRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRGGFRGGRGGREFADFEYRKTTAFGP
What is the function of this protein?
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985).  Acts as a repressor of mRNA translation (PubMed:29510985).  May play a role in mitotic spindle assembly (PubMed:26339800).
What are the official names of this protein?
Protein LSM14 homolog A, Protein FAM61A, Protein SCD6 homolog, Putative alpha-synuclein-binding protein, AlphaSNBP, RNA-associated protein 55A, hRAP55, hRAP55A.
What is the protein family that this protein belongs to?
Belongs to the LSM14 family.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, Stress granule.
Protein: RK23_SPIMX
Sequence: MDKIKYRPIGMKAIRLLERRQYTFDVDVKATKTEVKRWIEGFFSVKVVGMNSHRPPKKKKRMGSVIGYPVRYKRMIVTLKVGDSIPLS
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BGALA_NEOFI
Sequence: MKLLSVCAVALLAAQAAGASIKHKLNGFTIMEHSDPAKRELLQKYVTWDEKSLFVNGERIMIFSGEVHPFRLPVPSLWLDVFQKIKALGFNCVSFYVDWALLEGKPGKYRAEGNFALEPFFDAAKQAGIYLLARPGPYINAEASGGGFPGWLQRVNGTLRTSDPAYLKATDNYIAHVAATVAKGQITNGGPVILYQPENEYSGACCNATFPDGDYMQYVIDQARNAGIVVPLINNDAWTGGHNAPGTGKGEVDIYGHDSYPLGFDCGHPSVWPKGNLPTTFRTDHLRESPTTPYSLIEFQAGSFDPWGGPGFAACAALVNHEFERVFYKNDLSFGAAILNLYMTFGGTNWGNLGHPGGYTSYDYGSPLTESRNVTREKYSELKLIGNFVKASPSYLLATPGNLTTSGYADTADLTVTPLLGNGTGSYFVVRHTDYTSQASTPYKLSLPTSAGRLTVPQLGGTLTLNGRDSKVHVVDYNVAGTNILYSTAEVFTWKKFGDSKVLVLYGGPGEHHELAVSLKSDVQVVEGSNSEFTSKKVEDVVVVAWDVSASRRIVQIGDLKIFLLDRNSAYNYWVPQLDKDDSSTGYSSEKTTASSIIVKAGYLVRTAYTKGSGLYLTADFNATTPVEVIGAPSNVRNLYINGEKTQFKTDKNGIWSTGVKYSAPKIKLPSMKDLDWKYLDTLPEVQSTYDDSAWPAADLDTTPNTLRPLTMPKSLHSSDYGFHTGYLIYRGHFVADGSETTFDVRTQGGSAFGSSVWLNEAFLGSWTGLNANADYNSTYRLPQVEKGKNYVLTVVIDTMGLNENWVVGTDEMKNPRGILSYKLSGRDASAITWKLTGNLGGEDYQDKIRGPLNEGGLYAERQGFHQPEPPSKKWKSASPLDGLSKPGIGFYTAQFDLDIPSGWDVPLYFNFGNSTKSAYRVQLYVNGYQYGKFVSNIGPQTSFPVPQGILNYQGTNWVALTLWALESDGAKLDDFELVNTTPVMTALSKIRPSKQPNYRQRKGAY
What is the function of this protein?
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
What are the official names of this protein?
Probable beta-galactosidase A, Lactase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL18_ORENI
Sequence: MGVDIRHNKDRKVHRKEPKSQDIYLRLLVKLYRFLARRSNAPFNRVVLRRLFMSRTNRPPIAVSRLIRKMKLPGRENKIAVVVGTVTDDVRIQDIPKLKICALRVTDGARRRILKAGGQVMTFDQLALASPKGQGTVLLSGPRKAREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASCGYKN
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL18 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: Y437_RICPR
Sequence: MKKQIIYPDFITRIFSTALDLSLVAFIAIPISQFCFFNLLWLFFHDYFLSIKINIHNSNEMFNSIMSQEFYEYLKLGNFNKYILFNILIFATNILVICSYFITFWYYKGTTLSKMFLRMKIVDAVTLNRPTLKQLIKRFLAYITFPIGIFFILFSSKKQALHDRIAGTVVIKS
What are the official names of this protein?
Uncharacterized protein RP437.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LGUL_PINST
Sequence: ITACLDPDGWKEPGPLPGISTK
What is the function of this protein?
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
What are the official names of this protein?
Putative lactoylglutathione lyase, Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, PS3, S-D-lactoylglutathione methylglyoxal lyase.
What is the protein family that this protein belongs to?
Belongs to the glyoxalase I family.
Protein: KBX1_TITDI
Sequence: MERKLALLLLLGMITLASSGLREKHVQKLVTLIPNDTLRSIMKTIVHKLAKTQFGCPAYEGYCMNHCQDIERHDGSCHGFKCKCEKS
What is the function of this protein?
Blocks voltage-gated potassium channels.
What are the official names of this protein?
Potassium channel toxin Tdi-beta-KTx, TdibetaKTx.
What is the protein family that this protein belongs to?
Belongs to the long chain scorpion toxin family. Class 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: IL16_MACMU
Sequence: MDYSFDTTAEDPWVRISDCIKNLFSPIMSENPGHMPLQPNASLSEEDGTQGHPDGNPPKLDTANGTPKVYKSADRSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGPHIRASSSSSIKQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEGGRFSGLLGRGAAPTLVPQQPEQVLPSGSPAATEARDPGVSESPPPGLQPNQKTLPTGSDPLLRLLPTQTEKSQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSLSCAQTPCIPKEGASPTSSSNEDSAANGSAETSASDTGFSLNLSELREYTEGLTEAKEDDDGDHSSHQSGQSVISLLSSEELKQLIEEVKVLDEATLKQLDSIHVTILHKEEGAGLGFSLAGGADLENKVITVHKVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHNDALAILRQAREPRQAVIVTRKLTAESMPDLNSTTDSAASASAASDVSVESSAEATVYTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETIQPGDEILQLAGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQPKETTAAADS
What is the function of this protein?
Pro-interleukin-16 is involved in cell cycle progression in T-cells.  Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene.  May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity).
What are the official names of this protein?
Pro-interleukin-16.
What are the subcellular locations of this protein?
[Interleukin-16]: Secreted. SUBCELLULAR LOCATION: [Pro-interleukin-16]: Cytoplasm. Nucleus.
Protein: REX_PORGI
Sequence: MKTIANESFLLDTKVPEPTLRRLPWYLSYVQLLHADGCESVSSTRIARAVGVDASLVAKDLSYVSVDGRTRVGYRVADMVAVLNDFLGFTHHHRAFLFGVGSLGAALLQDSGLRHFGLEIAAGFDVNPDIVDTNINGIPVYHKSRVAELCARERVDIGILTVPIRAAQSMADEMIAAGIKAIWNFTPWRISVPEGVVVQNTSMYAQLAVMFNRMKSLP
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP1_CAEEL
Sequence: MDDELDYGSDHSIHGDVREDLSDSELQLPKDRLDAIIDRKEKIATEKAFGINDSSDKHLNVSIAETAALRKEIGASDQNSHLDSIYAHGVEAMDEFEIQKMFANFRPEKVWKKDNVAMVQFQYRRDVAAMMLNMSKMMRRVRGRKKADEEGEVLSDDDDVEEGQIMQEKDDDVELIEDLKPNEKGIVASEKNNEFITVDINAREVPNGKWRVLTKHVPANMFVIIRYATTDEYQTMVTSDRSQVKKTGVKRGNDSFWTHESSNRGGLNVFDKEGKELEWDYEHDTRFYNEDKNEEKVEKVKLPQGIKIKGRGAVKCGFLFGEGSSSLASDDTTPVKKRRTDEKDYEKDDIVSRQGSSAHAIRPGRVERPIRERIQFPGREDPDEY
What are the official names of this protein?
Protein kup-1.
Protein: TRI33_HUMAN
Sequence: MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
What is the function of this protein?
Acts as an E3 ubiquitin-protein ligase.  Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway.  According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4.  May act as a transcriptional repressor.  Inhibits the transcriptional response to TGF-beta/BMP signaling cascade.  Plays a role in the control of cell proliferation.  Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).  Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM33, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, RING-type E3 ubiquitin transferase TRIM33, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Nucleus. Note=In discrete nuclear dots resembling nuclear bodies.
Protein: TAGH_STAAB
Sequence: MNVSVNIKNVTKEYRIYRTNKERMKDALIPKHKNKTFFALDDISLKAYEGDVIGLVGINGSGKSTLSNIIGGSLSPTVGKVDRNGEVSVIAISAGLSGQLTGIENIEFKMLCMGFKRKEIKAMTPKIIEFSELGEFIYQPVKKYSSGMRAKLGFSINITVNPDILVIDEALSVGDQTFAQKCLDKIYEFKEQNKTIFFVSHNLGQVRQFCTKIAWIEGGKLKDYGELDDVLPKYEAFLNDFKKKSKAEQKEFRNKLDESRFVIK
What is the function of this protein?
Part of the ABC transporter complex TagGH involved in teichoic acids export.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Teichoic acids export ATP-binding protein TagH.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Teichoic acids exporter (TC 3.A.1.104.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: FPG_ECODH
Sequence: MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDQPVLSVQRRAKYLLLELPEGWIIIHLGMSGSLRILPEELPPEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTKELEGHNVLTHLGPEPLSDDFNGEYLHQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVIKAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATFYCRQCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: Y9774_DICDI
Sequence: MSHQSIDKEFKKPNNHQKIIPDEKTPNTKQEKREAYKLLKNKKPKDKKITYQSKMNNPEIHRYDYI
What are the official names of this protein?
Putative uncharacterized protein DDB_G0293150.
Protein: RIMP_ANAD2
Sequence: MTGIGEQSIAEQVRRLLEPVLERDGYELVEVEWARLAGRWTLRVFIDKAGGVGIDDCQAVSKTVEPILDVADVIEPAYDLEVSSPGLDRPLRKPGDFDRYAGQRVHVKAYGPVAGTAPGAPARKHWTGVLKGFRDGAVELDVDGVLHRVPHDQIAKANLEYDVEGDLRRKD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_CERSK
Sequence: MTAKPEHYDVIRKPVITEKATMTSEANGVVFAVAMEATKPQIKEAVEAIFNVKVKAVNTVVTKGKTKKFKGRPGVRSDRKKAYVTLEEGNTIDVSTGL
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.