PharMolix/UniProtQA huggingface dataset:
Protein: NMDA1_DROGR
Sequence: MRVAFIYRWLLCGAAIVNVLVAQRHTASDNPSTYNIGGVLSNSDSEEHFRTTIAHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIEKRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFLYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALHANNTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREHQKQHVVGKFSYDSPRGKMRMRINDSEIIWGGKQKRKPEGIMIPTHLKLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNASGATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNSGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMESNNYVTAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLMATHAPGTISLAVDKRRYPRLGQRLGPERAWPGDGADVLRIRRPYDLGKGGLTASQLGLGKTRPQQNPLPPRYSPGYTSDVSHLVV
What is the function of this protein?
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.  Mediated by glycine.  This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning.  It mediates neuronal functions in glutamate neurotransmission.  Is involved in the cell surface targeting of NMDA receptors.  Plays a role in associative learning and in long-term memory consolidation (By similarity).
What are the official names of this protein?
Glutamate [NMDA] receptor subunit 1.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane. Postsynaptic density.
Protein: TRPD_XANCP
Sequence: MPITPQQALQRTIEHREIFHDEMVDLMRQIMRGEVSDAMVSAILTGLRVKKETIGEIAGAATVMREFSRRVEVTDRRHMVDIVGTGGDGSHTFNISTCAMFVAAAGGAKVAKHGNRSVSSKSGSADALEALGAVIELQPEQVAASLAQTGIGFMYAPVHHPAMKVVAPVRREMGVRTIFNILGPLTNPAGSPNILMGVFHPDLVGIQARVLQELGAERALVVWGRDGMDELSLGAGTLVGELRDGQVHEYEVHPEDFGIAMSASRNLKVADAAESRAMLLQVLDNVPGPALDIVALNAGAALYVAGVADSIADGIVRARQVLADGSARACLDAYVAFTQQATAQG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: Y559_MYCTU
Sequence: MKGTKLAVVVGMTVAAVSLAAPAQADDYDAPFNNTIHRFGIYGPQDYNAWLAKISCERLSRGVDGDAYKSATFLQRNLPRGTTQGQAFQFLGAAIDHYCPEHVGVLQRAGTR
What are the official names of this protein?
Uncharacterized protein Rv0559c.
Protein: EFG_PSELT
Sequence: MLEIEALYVPLSKLRNIGIMAHIDAGKTTTTERILYYTGRKHVLGSVDEGTATMDWMEQEKERGITIKAAATTCFWKEHRINIIDTPGHVDFTVEVERALRVLDGAVAVFDATAGVEPQSETVWRQAERYSVPRIAFMNKMDKTGADFFMSIKSMVEKLHAKPVAIQVPIGAEKDFIGVVDLIEMKAITWTSEDGSEFIKHEIPENMLDLAEEMREEMISMLAEEDEELLELYLEEQELPVEKIKDILRKATINNKLVPVLCGAAARNKGIQPLLDAVVDYLPSPIDIPAVKAITPSGEEIQIPPSVEGDFAGLAFKIQTDPYVGKLAYVRVYSGKLEKGSYVYNSTKQIRERVARLIFMHADKREDAEYARAGDIVAIIGLKNTTTGDTLCSQERPVLLEKMSFPEPVISIAIEPLTRDDEERMVKAVAALSEEDPTLRINVDRETGQVVLSGMGELHLEIVTDRLKREFGVNVRVGRPQVSYRETIRQTGTAEGKYVRQTGGRGQYGHVIMKFEPLPLDGEKQFEFINKTVGGVIPREYIPAIEEGVKEAMEMGVLAGYPMIGVRAVLLDGSYHEVDSSEIAFKVAASLAFKNAMKICQPVLLEPVMKLEVVVPEEYVGGIIADLNARRAQIESLESRINLRVIKAFVPLSELFGYATTLRSLSQGRAVHVAQFSHYKEAPDKVVEKVLKVV
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YLF2_YEAST
Sequence: MNIGGGKFLLGRISNNPTSGIVGLANVGKSTFFQAITNSKLGNPANYPFATIDAECAKVNIPSVPLSNLLRIYQSAKCVPGTLTIYDIAGLTRGASQGHGLGNKFLNDIRHVEGIFQVVRGFLKEDITHIEGNVDPVRDLSVVQDELILKDLEFLENIRERLSKKMRMVSKNSKEHQEMKIETELLDALEEHLFNGKKIRHFKDHWNLDEVKILNKHNFLTSKPTLILLNVSPQDYVRNENKFVRNIIEWINEFSPGDKFLLFSAEFESQLMECKGIASEYFDKIKEDTNVSDQQLVSAIPQIILEMRKLLNLISFFTCGPQEVHQWNIREGTTAQEAAGVIHSDLRETFISADVIKYDDLKKMEPPLNESLLKSKGLIKRAGKQYIMQDNDIALFKAAGGKIKK
What is the function of this protein?
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency.  Has lower affinity for GTP (By similarity).
What are the official names of this protein?
Obg-like ATPase homolog, OLA1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ZN892_HUMAN
Sequence: MEPEGRGSLFEDSDLLHAGNPKENDVTAVLLTPGSQELMIRDMAEALTQWRQLNSPQGDVPEKPRNLVLLGLPISTPDVISQLEHEEELEREVSKAASQKHWETIPESKELTPEKDISEEESAPGVLIVRFSKESSSECEDSLESQQENHEKHLIQEAVTEKSSRERSYQSDEFRRNCTQRSLLVQQQGERLHHCDSFKNNLKQNSDIIRHERICAGKKPWKCNECEKAFSYYSAFVLHQRIHTGEKPYECNECGKAFSQSIHLTLHQRIHTGEKPYECHECGKAFSHRSALIRHHIIHTGEKPYECNECGKAFNQSSYLTQHQRIHTGEKPYECNECGKAFSQSTFLTQHQVIHTGEKPYKCNECGKAFSDRSGLIQHQRTHTGERPYECNECGKAFGYCSALTQHQRTHTGEKPYKCNDCAKAFSDRSALIRHQRTHTGEKPYKCKDCGKAFSQSSSLTKHQKTHTGEKPYKCKECGKAFSQSSSLSQHQKTHAGVKTKKYVQALSEHLTFGQHKRIHTG
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 892.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
Protein: RL44E_THEAC
Sequence: MKMPKKIMTYCPYCKKHTSHSVERVRKRKASELKAGQRRFRRVTSGYGGFPRPKFEGREKPTKRIALRLVCDECHKAITPPGIRAKKFEIVEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L44e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL42 family.
Protein: NEUL1_HUMAN
Sequence: MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS
What is the function of this protein?
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory.  Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3.  Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2.  Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway.  Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
What are the official names of this protein?
E3 ubiquitin-protein ligase NEURL1, Neuralized-like protein 1A, h-neu, h-neuralized 1, RING finger protein 67, RING-type E3 ubiquitin transferase NEURL1.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Postsynaptic density. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface.
Protein: NRIP1_HUMAN
Sequence: MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAVDKKSAGHNEEDQNFNISGSAFPTCQSNGPVLNTHTYQGSGMLHLKKARLLQSSEDWNAAKRKRLSDSIMNLNVKKEALLAGMVDSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHDSLKVEKDLRCYGVASSHLKTLLKKSKVKDQKPDTNLPDVTKNLIRDRFAESPHHVGQSGTKVMSEPLSCAARLQAVASMVEKRASPATSPKPSVACSQLALLLSSEAHLQQYSREHALKTQNANQAASERLAAMARLQENGQKDVGSYQLPKGMSSHLNGQARTSSSKLMASKSSATVFQNPMGIIPSSPKNAGYKNSLERNNIKQAANNSLLLHLLKSQTIPKPMNGHSHSERGSIFEESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRTEKSESDQPVSLDNFTQSLLNTWDPKVPDVDIKEDQDTSKNSKLNSHQKVTLLQLLLGHKNEENVEKNTSPQGVHNDVSKFNTQNYARTSVIESPSTNRTTPVSTPPLLTSSKAGSPINLSQHSLVIKWNSPPYVCSTQSEKLTNTASNHSMDLTKSKDPPGEKPAQNEGAQNSATFSASKLLQNLAQCGMQSSMSVEEQRPSKQLLTGNTDKPIGMIDRLNSPLLSNKTNAVEENKAFSSQPTGPEPGLSGSEIENLLERRTVLQLLLGNPNKGKSEKKEKTPLRDESTQEHSERALSEQILMVKIKSEPCDDLQIPNTNVHLSHDAKSAPFLGMAPAVQRSAPALPVSEDFKSEPVSPQDFSFSKNGLLSRLLRQNQDSYLADDSDRSHRNNEMALLESKNLCMVPKKRKLYTEPLENPFKKMKNNIVDAANNHSAPEVLYGSLLNQEELKFSRNDLEFKYPAGHGSASESEHRSWARESKSFNVLKQLLLSENCVRDLSPHRSNSVADSKKKGHKNNVTNSKPEFSISSLNGLMYSSTQPSSCMDNRTFSYPGVVKTPVSPTFPEHLGCAGSRPESGLLNGCSMPSEKGPIKWVITDAEKNEYEKDSPRLTKTNPILYYMLQKGGNSVTSRETQDKDIWREASSAESVSQVTAKEELLPTAETKASFFNLRSPYNSHMGNNASRPHSANGEVYGLLGSVLTIKKESE
What is the function of this protein?
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1.  Also modulates transcriptional repression by nuclear hormone receptors.  Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.  Involved in the regulation of ovarian function (By similarity).  Plays a role in renal development (PubMed:28381549).
What are the official names of this protein?
Nuclear receptor-interacting protein 1, Nuclear factor RIP140, Receptor-interacting protein 140.
What are the subcellular locations of this protein?
Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
Protein: KDM4A_DROME
Sequence: MSTRSSFADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTIPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQENLRAAKSEEESPQKRGCSLAGNGCERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAPKRYDFNTEAVVRVKRLWNELPCPDRGANLLTNGVVKNTKRMRFQTKVLTLDDED
What is the function of this protein?
Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code.  Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
What are the official names of this protein?
Probable lysine-specific demethylase 4A, Probable JmjC domain-containing histone demethylation protein 3A, Probable [histone H3]-trimethyl-L-lysine(36) demethylase 4A, Probable [histone H3]-trimethyl-L-lysine(9) demethylase 4A.
What is the protein family that this protein belongs to?
Belongs to the JHDM3 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KAD_PARXL
Sequence: MRLILLGAPGAGKGTQATFIKEKFGIPQISTGDMLRAAVKAGTPLGLEAKRFMDAGELVTDELIINLVKERLQQPDCANGYLFDGFPRTIPQAEAMKQAGVAIDYVLEIDVPFEEIIVRMSGRRSHAASGRTYHVKFNPPKVEGLDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLIEYYTNWAKNGDSSTPLKAPQYRRISGLGSVDEIRERAFEALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_NATTJ
Sequence: MKTRPSVKPICERCKVIKRRGKVMVICSNPKHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: MDCC_PSEFS
Sequence: METLSFEFPAGQPPKGRALVGCVGSGDLEVLLEPGTPGTLTIQVQTSVNGAEQRWQHLFERIFQEQTPPALNIDIHDFGATPGVVRLRLEQGFEEIGHD
What is the function of this protein?
Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.
What are the official names of this protein?
Malonate decarboxylase acyl carrier protein, Malonate decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the MdcC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: US07_HCMVM
Sequence: MRIQLLLVSTLVASIVATRVEDMATFRTEKQWQQDLQYRREFVKRQLAPKPKSNIVVSHTVSCVIDGGNMTSVWRFEGQFNPHIASEVILHDTSGLYNVPHEVQNDGQVLTVTVKRSAPADIAKVLISLKPVQLSSGQYECRPQLQLPWVPRPSSFMYDSYRLWYEKRWLTIILYVFMWTYLVTLLQYCIVRFIGTRLFYFLQRNITIRFTGKPTYNLLTYPVKG
What are the official names of this protein?
Membrane glycoprotein US7.
What is the protein family that this protein belongs to?
Belongs to the cytomegalovirus US6 family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RS20_CYAP4
Sequence: MANIKSAIKRVEITERNRLHNKSYKSAVKTLTKKYFDAVAAYSASPSNDALQAAQTSLSAAFSKIDKAVKRGVIHRNNGARKKARLARALNRHLANAAS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RL27_CHLTA
Sequence: MAHKKGQGASRNGRDSESKRLGLKVGAGQRVSTGSILVRQRGTKWHPAVNVGRGKDDTLFALVDGIVVMKKTDRTYVSVIPQA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: MTC6_CANTT
Sequence: MKPVYCFSILALLQIFTVVVSESNWPTLNFTLEIASRAQRDISKLLPISQITTVGISLSSIFRNSGYTVDALSPLYDLLNGGNEAIMIDLYWNEFTSQWQLCPAPFPSNTTYNMNDVVDLSWENNDYQCQPGLSTENIMGIINSYIRDTNTNIGANFLRILFNLKSIHYENSNRTIDLQNIYKPSILNPVNIGNDTLNDTIASLGSYIFTPTVLSQYQSDASHVEKASSGSSINSTQAISYFYNQSNIIVPSLDTVLLSEYKRVSAHISSNELVNSSRVYQFTSYDTDLIFFNDVVPLVVENTTTGVAGRYCNELFNAYNSTGVDIETFNNLSLTTRLRFIVDSDENPFTVDTLSKFVRCGYSAIFNGTYDVGVNSSSLDFSDEVDEFIPYGFWSWSPGQPVDLNDTNSDSINNASMSSNNTDDSNGNSLAFKCVVLTETGWSVANCYDRHVIACQNSTSRNNWVLQETNKRNYFEIDKGDCPEGYTFSIPRSSTEMLSLQATVKQRNVPYPIWLDLNDITVPNCFVSGGPYAQCPYQRTITTNKFVRMIAPSFAVGVVVLVLILIENIFRTNPIQTNRKRYWKKAIQEYYNKNDFEGVPS
What is the function of this protein?
May be involved in telomere capping.
What are the official names of this protein?
Maintenance of telomere capping protein 6.
What is the protein family that this protein belongs to?
Belongs to the MTC6 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: VE2_HPV60
Sequence: MNQADLTERSDALQEQILNLYEQDSKDIQAQIQYWDLNRKLYVTYYYARKEGYSHLGLQPLPALQVSEYKAKQAIEMGLLLTSLSKSQYASELWGLTDTSAELLLTPPRNTFKKKGYTVNVWFDNNENNTFPYTNWEYIYYQDDIEQWHRTRGEVDYNGLYFTENNGNRAYFLLFDSDAQTYSQTGTWTVHYKNQIISAPVTSSSKQSSDDYTSKAGQQPHFFASSSSPTTTDGGQTSQEGVSSSTTSPSAVRLRRRRSNEQQRELSSRESPRTKRRRVPDEVDRQSAVGSAPTAEEVGSRHRSLPRSGISRLARLQGEARDPPILLIKGLANSLKCWRYRLKKYTRYFKCMSTVFRWVDIDVPESSRHKLLVVFNDTTQRDVFMKLVTLPRGCTYTFGTLNSL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RLMN_GEMAT
Sequence: MTVLPDLLDFDPDAALALLGEWMAARGEPAYRAAQVFGRLWQRPVRSFDEMTELPKALREGLAGSFRITALELTTRQKSMDGTEKFLFRMHDGQLIETVAIPDGDRLTFCISSQAGCALQCAFCATGAMGFQRNLHPSEIAGQVRELRMLTPSIVPTNIVFMGMGEPLMNWKAVSPTLSLLNDPRALGIGARHITISTVGVLPGIVALAARPEQFRLAISIHAPSDALRRTLMPVNTKYPLADVIAAAREFDRRVTFEYVMLGGVNDQPEHAAQLAQLARDCRAFVNLIPLHPGGSMGFSPSTTPTINAFAKAIRARGVETAVRRSRGLDIAAACGQLRTERLGRRLPVAAQDHGEVHVA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR154_MIMIV
Sequence: MDNLKVLFEENLFSDLQLIVEDSNESIVLNVHRNILYFSCDFFKKLLIGQFSETNDKSIKIIVHNAKITSCVIKNFYGIDDKLPEYPDWMYYLETYRCYDYFGMKIPVDKLLELTVPSEGFELLLQIVDLLDYCDELGHLIIRNLPLDYDINDLSKDFVTDLQRLSNEYQIICTKHHTIKIFNNKLYKPIKTIHHSENITSLCYDNNNKRIIYGDLKGTIYAYDFFSNKIIFNLQNIQTNKTLPNNVIHLAIINDKLISVYFDGKITVRNSLDGTLCYVIKLIENPFLFKVCPHTNCIFHFNTHGFTNVWSIDTGNLIHKLSQFTNTMFNTLKNDLIIFWRENNLILCNYPSMDEIGTLCKEYSFPPLVLLNKQHILVGCHNGLMDIWNLKKLTLVKSTQLFDVPIISMTYSPNGDQLIVANCDREVRILNSDNYEIIYTKNINKDNNNKLLTISLHDAEKIEKLNIL
What are the official names of this protein?
Putative BTB/POZ domain and WD-repeat protein R154.
What is the protein family that this protein belongs to?
Belongs to the mimivirus BTB/WD family.
Protein: EGFL7_RAT
Sequence: MWGSGELLVAWFLVLAAGGTTEHVYRPSRRVCTVGVSGGSISETFVQRVYQPYLTTCDGHRACSTYRTIYRTAYRIAYRHSPGLTPSRPRYACCPGWKRTNGLPGACGAAICQPPCGNEGSCIRPGRCRCPVGWQGDTCQIDVDECSTGEARCPQRCVNTVGSYWCQCWEGQSPSADGVLCLPKEGPSPVAPSPTPGVDSVVREEVYKLQARVDVLEQKLQLVLAPLHSLASRSPEHGLQDPGSLLAHSFQQLDRIDSLSEQVSFLEEQLGSCSCKKDL
What is the function of this protein?
Regulates vascular tubulogenesis in vivo.  Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis (By similarity).
What are the official names of this protein?
Epidermal growth factor-like protein 7, EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, Multiple EGF-like domains protein 7.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: SMYDL_CAEEL
Sequence: MAVKKNKNVPKQEDPLVQKDEISSIHARIKIFETPFATQVLNPKVSEFCANCLRGPAPGEKLLRCGGCNFSMYCSKECQATAWLVHKPECKRLKASFPNLPLTEVLFLSKVIDRIQFLEKNGDKLGIEAERKFSSLVDHKVDIRDDEEKMAHFEKIFEKMGAFRGEEMIEKGEFFDVFCKATINSHSIHTNAGNEVGMALDLGVSKYNHSCRPTCSMVFDGYRVCLRPLVPGVDAENTEEAFISYIDVGRSKYIRRRDLNSRWYFNCECTRCMDPEDDALTAIRCANPACDAPILTSETEEPMNIACEKCKTIVEEDTVKAAQEYMKTLPASFDPKCPAEIEALPGKLKELLAKAEQILHPSNVYVARLRTALFHVTGTLTMDNLSSMHTQIYNNYKMCFPKADRHVGFQLLHIVKALIEKDERDEAMPYAFDAMNIFEVCFGLDHPYYLQTLALWTYLEKKIPKSTEELVQLTNFSDNRPIDIVSLLKRANMLPPPPYAAGTPGVA
What is the function of this protein?
Histone methyltransferase (PubMed:29514099).  Specifically methylates 'Lys-36' of histone H3, inducing di-methylation (PubMed:29514099).  Plays a role in modulating lifespan and oxidative stress resistance, in a manner dependent upon daf-16/Forkhead box protein O and the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:29514099).  Represses transcription of daf-16 isoform a, perhaps by methylating histone H3 at the daf-16 promoter, which in turn leads to recruitment of histone deacetylases and thus modulation of expression (PubMed:29514099).
What are the official names of this protein?
Histone-lysine N-methyltransferase set-18.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.
Protein: MTLK_CERSP
Sequence: MTRSVTRPSYDRKALTPGIVHIGVGNFHRAHQAVYLDDLFALGEGHDWAILGAGVRPTDARMREALAAQDNLSTVIELDPAGHRARQVGAMVGFLPVEADNAALIEAMSDPRIRIVSLTVTEGGYYVDASGAFDPTHPDIVADAAHPARPATAFGAILAALRARRDAGVTPFTVMSCDNLPGNGHVTRNAVVGLAELYDAELAGWVKAQVAFPNGMVDRITPATGPHERELAQGFGLADPVPVTCEPFRQWVIEDHFPAGRPALEKVGVTFTPHVHAYEAMKIRILNGGHAVIAYPSALMDIQLVHAAMAHPLIAAFLHKVEVEEILPHVPPVPDTSIPDYLTLIESRFSNPEIADTTRRLCLDGSNRQPKFIVPSLRDNLAAGTVPKGLVLLSALWCRYCFGTTDSGVVVEPNDPNWTALQDRARRAKETPAEWLAMTEVYGDLAQNDLLAAEFAAALEAVWRDGAEAVLRRFLAA
What are the official names of this protein?
Mannitol 2-dehydrogenase, M2DH, MDH.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: IHFA_ACTSZ
Sequence: MTLTKVEIAENLTRKLELNKTEAKAMVESFFEEIRATLADGHNVKLSGFGNFELRDKASRPGRNPKTGENIPVSARRVVVFRPGQKLRARVEKSKPKG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: GLL10_CHICK
Sequence: MKILCLLFAVLLFLFQAAPGSADPLFPDTVACRTQGNFCRAGACPPTFTISGQCHGGLLNCCAKIPAQ
What is the function of this protein?
Has bactericidal activity.
What are the official names of this protein?
Gallinacin-10, Gal-10, Beta-defensin 10, Gallinacin-8, Gal-8.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule.
Protein: KCS19_ARATH
Sequence: MELFSLSSLLLLSTLFVFYIFKFVFKRRNQRNCYMLHYECYKGMEERKLDTETCAKVVQRNKNLGLEEYRFLLRTMASSGIGEETYGPRNVLEGREDSPTLLDAHSEMDEIMFDTLDKLFHKTKGSISPSDIDILVVNVSLFAPSPSLTSRVINRYKMREDIKSYNLSGLGCSASVISIDIVQRMFETRENALALVVSTETMGPHWYCGKDRSMMLSNCLFRAGGSSVLLTNAARFKNQALMKLVTVVRAHVGSDDEAYSCCIQMEDRDGHPGFLLTKYLKKAAARALTKNLQVLLPRVLPVKELIRYAIVRALKRRTSAKREPASSGIGLNLKTGLQHFCIHPGGRAIIEGVGKSLGLTEFDIEPARMALHRFGNTSSGGLWYVLGYMEAKNRLKKGEKILMMSMGAGFESNNCVWEVLKDLDDKNVWEDSVDRYPELSRIPNPFVEKYDWINDDTMSFVRVD
What are the official names of this protein?
3-ketoacyl-CoA synthase 19, KCS-19, Very long-chain fatty acid condensing enzyme 19, VLCFA condensing enzyme 19.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.