PharMolix/UniProtQA huggingface dataset:
Protein: NPIIA_ASPOR
Sequence: MRFISVSSLLLALAPALNAVPVEVAGSAQGLDVTLSQVGNTRIKAVVKNTGSEDVTFVHLNFFKDAAPVQKVSLFRNATEVQFQGIKQRLITEGLSDDALTTLAPGATIEDEFDIASTSDLSEGGTITINSNGLVPITTDNKVTGYIPFTSNELSIDVDAAEAASVTQAVKILERRTKVTSCSGSRLSALQTALRNTVSLARAAATAAQSGSSSRFQEYFKTTSSSTRSTVAARLNAVANEAASTSSGSTTYYCSDVYGYCSSNVLAYTLPSYNIIANCDLYYSYLPALTSTCHAQDQATTTLHEFTHAPGVYSPGTDDLGYGYSAATALSASQALLNADTYALFANAVNLNC
What is the function of this protein?
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.  Shows high activities on basic nuclear substrates such as histone and protamine (By similarity).
What are the official names of this protein?
Neutral protease 2 homolog AO090001000135, Deuterolysin AO090001000135.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: YFEO_ECOBW
Sequence: MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OMPF_SERMA
Sequence: MMKRNILAVVIPALLAAGAANAAEIYNKDGNKLDLYGKVDGLHYFSKDKGNDGDQTYVRFGFKGETQITDQLTGYGQWEYNVQSNHAESQGTEGTKTRLGFAGLKFADYGSFDYGRNYGVLYDVEGWTDMLPEFGGDTYTYSDNFMTGRTNGVATYRNNNFFGLVDGLNFALQYQGKNQNDGRDVKKQNGDGWGISSTYDIGEGVSFGAAYASSNRTDDQKLRSNERGDKADAWTVGAKYDANNVYLAAMYAETRNMTPFGGGNFTNTCAATENCGGFASKTQNFEVTAQYQFDFGLRPEVSYLQSKGKNLNVPGVGSDQDLVKYVSVGTTYYFNKNMSTYVDYKINLLDDNDFTKATGIATDDIVGVGLVYQF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Outer membrane protein F, Porin OmpF.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: SYI_BACFR
Sequence: MSKKFAEYSQFDLSKVNKDVLKKWDENQVFAKSMTEREGCPSFVFFEGPPSANGMPGIHHVMARSIKDIFCRYKTMKGYQVKRKAGWDTHGLPVELGVEKSLGITKEDIGKTISVAEYNAHCRQDVMKFTKEWEDLTHKMGYWVDMKHPYITYDNRYIETLWWLLKQLYKKGLLYKGYTIQPYSPAAGTGLSSHELNQPGCYRDVKDTTVVAQFKMKNPKPEMAQWGTPYFLAWTTTPWTLPSNTALCVGPKIDYVAVQSYNAYTGQPITVVLAKALLNAHFNPKAAELKLEDYKAGDKLVPFKVIAEYKGPDLVGMEYEQLIPWVNPGEGAFRVILGDYVTTEDGTGIVHIAPTFGADDAQVAKAAGIPPLQLVNKKGELRPMVDLTGKFYTLDELDEDFIKQRVNIDLYKEYAGRFVKNAYDPNLSDQDESLDVSICMMMKVNNQAFKIEKHVHNYPHCWRTDKPVLYYPLDSWFIRSTACKERMIELNKTINWKPESTGTGRFGKWLENLNDWNLSRSRYWGTPLPIWRTEDNSDEKCIESVEELYNEIEKSVAAGYMQSNPYKDKGFVPGEYNEENYNKIDLHRPYVDDIILVSKDGKPMKREADLIDVWFDSGAMPYAQIHYPFENKELLDSHQVYPADFIAEGVDQTRGWFFTLHAIATMVFDSVSYKAVISNGLVLDKNGNKMSKRLGNAVDPFSTIEQYGSDPLRWYMITNSSPWDNLKFDVDGIEEVRRKFFGTLYNTYSFFALYANVDGFEYKEADLPMNERPEIDRWILSVLNTLVKEVDTCYNEYEPTKAGRLISDFVNDNLSNWYVRLNRKRFWGGGFTQDKLSAYQTLYTCLETVAKLMAPIAPFYADRLYSDLIGVTGRDNVVSVHLAKFPEYNEKMVDKELEAQMQMAQDVTSMVLALRRKVNIKVRQPLQCIMIPVVDEVQKAHIEAVKALIMSEVNVKEIKFVDGAAGVLVKKVKCDFKKLGPKFGKQMKAVAAAVAEMSQEAIAELEKNGKYTFDLGGAEAVIESADVEIFSEDIPGWLVANEGKLTVALEVTVTDELRREGIARELVNRIQNIRKSSGFEITDKIKLTLSKNPQTDDAVNEYNSYICNQVLGTSLTLADEVKDGTELNFDDFSLFVNVVKE
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNFC_MACMU
Sequence: MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTDTADPGAQAQQGLGFQKLPEEEPEADLSPGLPAAHLIGAPLKGQGLGWEATKEQAFLTSGTQFSDADGLALPQDGLYYLYCLVGYRGRAPPGGAEPRGRSVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPAGRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGAVMVG
What is the function of this protein?
Cytokine that binds to LTBR/TNFRSF3.  May play a specific role in immune response regulation.  Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity).
What are the official names of this protein?
Lymphotoxin-beta, LT-beta, Tumor necrosis factor C, TNF-C, Tumor necrosis factor ligand superfamily member 3.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: S35F6_RAT
Sequence: MAWTKYQLFLAGLMLVTGSINTLSAKWADNFEAEGCGGSQEHSFKHPFVQAVGMFLGEFSCLAAFYLLKCRARRQSDSSVEPRQPFNALLFLPPALCDMTGTSIMYVALNMTSASSFQMLRGAVIIFTGLFSVAFLDRRLVPSQWLGILITIAGLVVVGLADLLSKHDSQHKLSEVITGDLLIIMAQIIIAIQMVLEEKFVYKHNIHPLQAVGIEGFFGFVILSLLLVPMYYIPTASFSGNPRGVLEDALDAFCQVGRQPLIALALLGNISSIAFFNFSGISVTKELSATTRMVLDTLRTVVIWAFTLALGWEVFHPLQILGFLILLMGTALYNGLHRPLLACLSRRWRHPTQEGEQERLLGDSRTPINETS
What is the function of this protein?
Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells.  Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth.  May play a role as a nucleotide-sugar transporter (By similarity).
What are the official names of this protein?
Solute carrier family 35 member F6, ANT2-binding protein, ANT2BP, Transport and Golgi organization 9 homolog.
What is the protein family that this protein belongs to?
Belongs to the SLC35F solute transporter family.
What are the subcellular locations of this protein?
Mitochondrion. Lysosome membrane; Multi-pass membrane protein.
Protein: TR548_MIMIV
Sequence: MSKDSVETNTIINTIDNTNDNTTNITKKNSVEEIITLNDFSTALGDESKGLVIIDFFTTWCGPCKRIAPDYIRMAEKYPTVSFYKINAENENLANIVAACEIVSLPTFCFFKAGKYIGRFVNADPVGLEKSIVESSQ
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin-like protein R548.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: CAPSD_ICMV
Sequence: MSKRPADIIISTPGSKVRRRLNFDSPYSSRAAVPTVRVTKRQSWTNRPINRKPRWYRMYRSPDVPKGCEGPCKVQSFESRHDVVHIGKVMCISDVTRGIGLTHRVGKRFCVKSIYILGKIWMDENIKTKNHTNSVMFFLVRDRRPVDKPQDFGEVFNMFDNEPSTATVKNMHRDRYQVLRKWHATVTGGQYASKEQALVRRFFRVNNYVVYNQQEAGKYENHTENALMLYMACTHASNPVYATLKIRIYFYDSVSN
What is the function of this protein?
Encapsidates the viral DNA into characteristic twinned ('geminate') particles.  Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus.  The CP of bipartite geminiviruses is not required for cell-to-cell or systemic movement.
What are the official names of this protein?
Capsid protein, Coat protein, CP.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=It is actively transported into the host cell nucleus. It may be exported out of the nucleus through a nuclear export signal for cell- to-cell movement and spread (By similarity).
Protein: CO2_GORGO
Sequence: MGPLMVLFCLLFVYTGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASKPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRILGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDRIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
What is the function of this protein?
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a.  C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity).
What are the official names of this protein?
Complement C2, C3/C5 convertase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CMOA_YERPG
Sequence: MPNRDTQSQNDTPRHSPEAAEPQRDSLFAAPIAKLGDWTFDEKVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPNSQIYDLGCSLGAATLSMRRNIKAEGCKIIAVDNSPAMVERCRRHIDAFRAETPVDVVEADILDIKLENASMVVLNFTLQFLEPANRQRLLNQVYQGLRPGGALVLSEKFSFADHNVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKNRLHQAGFEHAEVWFQCFNFGSLIALKAGEAQ
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: RL14_RUEPO
Sequence: MIQMQTNLDVADNSGARRVQCIKVLGGSKRKYASVGDIIVVSVKEAIPRGRVKKGDVRKAVVVRTAKEVRREDGTAIRFDRNAAVILNNNNEPVGTRIFGPVVRELRAKNFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MSD6_AMAEX
Sequence: MSDINTTRLPFVFVASPPCVGDDIAMVLTRGENLC
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:24050899).
What are the official names of this protein?
MSDIN-like toxin proprotein 6.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: DNJC7_MOUSE
Sequence: MAATAECDVVMAATEPELLEDEDAKREAESFKEQGNAYYAKKDYNEAYNYYTKAIDMCPNNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAEVDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQFVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACVACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRQLEDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQFEEAVRDYEKVYQTEKTKEHKQLLKNAQLELKKSKRKDYYKILGVDKNASEDEIKKAYRKRALMHHPDRHSGASAEVQKEEEKKFKEVGEAFTILSDPKKKTRYDSGQDLDEEGMNMGDFDANNIFKAFFGGPGGFSFEASGPGNFYFQFG
What is the function of this protein?
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor.  Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required.  In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes (By similarity).  Recruits NR1I3 to the cytoplasm.
What are the official names of this protein?
DnaJ homolog subfamily C member 7, Cytoplasmic CAR retention protein, CCRP, MDj11, Tetratricopeptide repeat protein 2, TPR repeat protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 at microtubules.
Protein: Y1834_PSYA2
Sequence: MAIKDWHEDDRPREKLLKFGAAHLSDAEILAIFLRTGTQSQSAIDLARHLIEQFGSLAELLAAPQETVLACHGIGPAKYAQILASLEIGRRYLDSQLKTGQGLGRSQMVKDYISTHLRGEPREVFAVLCLDNALNLINFEILFTGGISSCSVCIKHVLRHALSHATSQLIIAHNHPHTDATPSTADNLLTYELKKACDLIDLSLIDHVIVGRNETLSYAENCLAPFG
What are the official names of this protein?
UPF0758 protein Psyc_1834.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: Y015_MYCGE
Sequence: MEGSWSYKLLYVFLCIVLGILYGIANPILLAQGLGFIFPITSSNGRAVDSIYSLIYPTNLNVFIRLTIVSVTVFVAYALIFVFNVAQNYVGIKLYQQTCATLRWKAYLKMQSMSTSFFDTQNNGDLMSRLTNDMYNIDNLFTQAGGQAIQSLFNILTTSVLIFLLSPVIALISLSILATLITFSFAFLKKSKTSYSQVQNNLGDMSGYIEEVLTNHKVVHVLKLQEIMIKDFDQYNKSMIKPTVRGNTYSIFLFSWFGFISNITYLVSISIATAFSVNSIPSFGISVINYSFMLSYIASLRQITLALDQIFTLWNLVQLGVVSAERVFKVLDLNVEKDTATIDKLPDIKGNIRFENVAFGYNKDKPTLTGINFSVKHGDVVAIVGPTGAGKSTIINLLMKFYKPFEGKIYMDNFEISDVTKKAWREKISIVLQDSFLFSGTIKENIRLGRQDATDDEIIAACKTANAHDFIMRLPKGYDTYISNKADYLSVGERQLLTIARAVIRNAPVLLLDEATSSVDVHSEKLIQESIGRLMKNKTSFIISHRLSIIRDATLIMVINDGKVLEMGNHDQLMKQNGFYARLKQSSVR
What are the official names of this protein?
Putative ABC transporter ATP-binding protein MG015.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SH2B3_HUMAN
Sequence: MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
What is the function of this protein?
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
What are the official names of this protein?
SH2B adapter protein 3, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk.
What is the protein family that this protein belongs to?
Belongs to the SH2B adapter family.
Protein: RIMO_CLOBB
Sequence: MTKYKVGMVSLGCDKNRVDSEIILGKMSNEYEITNNAKEADVIIVNTCGFIESAKQESIDTILEMAEYKNNYKCKLLIATGCLIQRYGDELKNLIPEIDIMLGVNDYNKIDKVIKEFIEGNKEASKLLNYSDENINEGNRILTTQKESAYIRIAEGCNNFCTYCIIPKIRGKFRSRRMENIISEATDLASQGVKELILIAQDTTQYGSDIYGKKNLHVLLKELSKIEGIKWIRVLYCYPEAIYDELIEEIAVNEKVVKYLDIPIQHISDHVLKLMGRKTSKKDITDKIEKLRKSIPNIIIRTTFIVGFPQETQEDFEEILEFLQEYKLDKVGVFKYSREEDTPASKMDGQIDEAIKKEREEKLMLSQEKISNDINKLKVNKKYDILIEEYDGEFYKGRNFEMAPDIDGNVFFESPKNLEIGEFVKVKIIKNMDYDLIGVVEDESCK
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSR2_SCHPO
Sequence: MFDDPSKRLTYFEYAVGVLLCSWPVMKQAVEEEWADVDTADKRDWMAGVLVDYITVTSDVEAWDVEELILQVLQDEFNVGSIEDDSPYILAQDLVNVWKAACEDNYEPIREIHERLGKQLLEKEEGKEKTREESNPPVLVEDETIVDAEDGGAAQNQQEKQQGPIVDDDGFTVVQKRRR
What is the function of this protein?
Required for 20S pre-rRNA processing.
What are the official names of this protein?
Pre-rRNA-processing protein tsr2.
What is the protein family that this protein belongs to?
Belongs to the TSR2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ERF1_TETTH
Sequence: MEEKDQRQRNIEHFKIKKLMTRLRNTRGSGTSMVSLIIPPKKQINDSTKLISDEFSKATNIKDRVNRQSVQDAMVSALQRLKLYQRTPNNGLILYCGKVLNEEGKEIKLLIDFEPYKPINTSLYFCDSKFHVDELGSLLETDPPFGFIVMDGQGALYANLQGNTKTVLNKFSVELPKKHGRGGQSSVRFARLRVEKRHNYLRKVCEVATQTFISQDKINVQGLVLAGSGDFKNELSTTQMFDPRLACKIIKIVDVSYGGENGLNQAIELAQESLTNVKFVQEKNVISKFFDCIAIDSGTVVYGVQDTMQLLLDGVIENILCFEELTTLRVTRKNKVTEQITHIFIPPNELNNPKHFKDGEHELEKIEVENLTEWLAEHYSEFGAELYFITDKSAEGCQFVKGFSGIGGFLRYKVDLEHIVNPNDEYNYEEEEGFI
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codon UGA.  In T. thermophila UAA and UAG codes for glutamine.
What are the official names of this protein?
Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, eRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLRA_MIZYE
Sequence: ADKERAQRATSNVFARLPQKLMQEMKEAFTMIDQNRDGFIDINDLKEMFSSLGRTPDDKELTAMLKEAPGPLNFTMFLSIFSDKLSGTDTEETLRNAFAMFDELDTKKLNIEYIKDLLENMGDNFTKDEMRMTFKEAPVTGGKFDYVKFTAMIKGSGEEEA
What is the function of this protein?
In molluscan muscle, calcium regulation is associated with myosin rather than with actin.  Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.
What are the official names of this protein?
Myosin regulatory light chain A, smooth adductor muscle.
Protein: CD14_BOVIN
Sequence: MVCVPYLLLLLLPSLLRVSADTTEPCELDDDDFRCVCNFTDPKPDWSSAVQCMVAVEVEISAGGRSLEQFLKGADTNPKQYADTIKALRVRRLKLGAAQVPAQLLVAVLRALGYSRLKELTLEDLEVTGPTPPTPLEAAGPALTTLSLRNVSWTTGGAWLGELQQWLKPGLRVLNIAQAHSLAFPCAGLSTFEALTTLDLSDNPSLGDSGLMAALCPNKFPALQYLALRNAGMETPSGVCAALAAARVQPQSLDLSHNSLRVTAPGATRCVWPSALRSLNLSFAGLEQVPKGLPPKLSVLDLSCNKLSREPRRDELPEVNDLTLDGNPFLDPGALQHQNDPMISGVVPACARSALTMGVSGALALLQGARGFA
What is the function of this protein?
Coreceptor for bacterial lipopolysaccharide.  In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS).  Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.  Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
What are the official names of this protein?
Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus. Note=Soluble, secreted forms seem to exist. They may arise by cleavage of the GPI anchor.
Protein: DDIT4_HUMAN
Sequence: MPSLWDRFSSSSTSSSPSSLPRTPTPDRPPRSAWGSATREEGFDRSTSLESSDCESLDSSNSGFGPEEDTAYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLAQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVGQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLFSSANSPFLPGFSQSLTLSTGFRVIKKKLYSSEQLLIEEC
What is the function of this protein?
Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1).  Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB.  Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage.  Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity.  Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity).  Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).  Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity.  Required for normal neuron migration during embryonic brain development.  Plays a role in neuronal cell death.
What are the official names of this protein?
DNA damage-inducible transcript 4 protein, HIF-1 responsive protein RTP801, Protein regulated in development and DNA damage response 1, REDD-1.
What is the protein family that this protein belongs to?
Belongs to the DDIT4 family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm, cytosol.
Protein: TIG_KLEP7
Sequence: MQVSVETTQGLGRRVTITIAADSIENAVKSELVNVAKKVRIDGFRKGKVPMNIVAQRYGASVRQDVLGDLMSRHFVDAIIKEKINPAGAPNYVPGEYKLGEDFTYAVEFEVYPEVELQGLDAIEVEKPVVEVTDADVDTMLETLRKQQATWKEKEGAVDAEDRVTIDFTGSVDGEEFEGGKASDFVLAMGQGRMIPGFEDGIKGHKAGEEFTIDVTFPEEYHAENLKGKAAKFVINLKKVEERELPELTEEFIKRFGVEDGSVAGLRAEVRKNMERELKGAVRNRVKSQAIEGLVKANEIDVPAALIDSEIDVLRRQAAQRFGGNEKQALELPRELFEEQAKRRVVVGLLLGEVIRTNELKADEERVKALIEEMASAYEDPSEVVEFYSKNKELMDNMRNVALEEQAVEAVLAKAKVSEKATSFNELMNQQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: Y562A_THEMA
Sequence: MLVKEREEKLNRVLVALLGIPVVFSIIRAKIVETIGYFIFWLGGFSPYVYEKITHQEIPERTKLMLSSSVFLHSVMGQFLNFYEKIFFWDKILHFYGSFVITYFFYQILTKKSRFWDEVPGAVLMAFLLGVFSGVLWEIAEFTTDKILPDYNTQKGLDDTMLDLIFDLLGCYTMAKIVYRKKTGRFFWRPRS
What are the official names of this protein?
Uncharacterized protein TM_0562.1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISAMP_IXOSC
Sequence: MRAVAIFIVTLLVLECVYFVMSEPDPGQPWQVKAGRPPCYSIPCRKHDECRVGSCSRCNNGLWGDRTCR
What is the function of this protein?
Has antimicrobial activity against B. cereus (MIC=5. 8 ug/ml), B. subtilis (MIC=12. 3 ug/ml), S. aureus (MIC=10. 4 ug/ml), E. coli Edl 933 (MIC=3. 2 ug/ml) and E. coli MG/655 (MIC=4. 2 ug/ml).  Non-hemolytic.
What are the official names of this protein?
Antimicrobial peptide ISAMP.
Protein: DMRA_METEA
Sequence: MIDVRCICAIGQRGQLGLNGHLPWEGNTDPLFVEDVTRFFALTMGHVLIAGPKTVASVPEFAFKDRTIDVIRSHEDPEAVLKRYPGRRIFVGGGIAVWNVYAKYIQHWDVTRLPYDGEADRWFDPAWLVGGPLRS
What is the function of this protein?
Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT).  Shows preference for NADPH rather than NADH as electron donor.  Does not reduce dihydrofolate.
What are the official names of this protein?
Dihydromethanopterin reductase, H(2)MPT reductase.