PharMolix/UniProtQA huggingface dataset:
Protein: C7BL3_CICIN
Sequence: MEPLTIVSLVVASLFLFAFWALSPKTSKNLPPGPPKLPIIGNIHQLKSPTPHRVLRNLARKYGPIMHLQLGQVSTVVVSTPRLAREIMKTNDISFADRPTTTTSQIFFYKAQDIGWAPYGEYWRQMKKICTLELLSAKKVRSFSSIREEELSRISKVLESQAGTPINFTEMTVEMVNNVICKATLGDSCKDQATLIEVLYDVLKTLSAFNLASYYPGLQFLNVILGKKAKWLKMQKQLDDILEDVLKEHRSKGSNKSDQEDLVDVLLRVKDTGGLDFTVTDEHVKAVVLDMLTAGTDTSSATLEWAMTELMRNPHMMKRAQDEVRSVVKGNTITETDLQSLHYLKLIVKETLRLHAPTPLLVPRECRQDCNVDGYDIPAKTKILVNAWACGTDPDSWKDPESFIPERFENCPINYMGADFEFIPFGAGRRICPGLTFGLSMVEYPLANFLYHFDWKLPNGLKPHELDITEITGISTSLKHQLKIVPMIPKSIAK
What is the function of this protein?
Hydroxylates germacrene A acid to 6-alpha-hydroxy-germacrne A acid, a precursor of sesquiterpene lactones that spontaneously undergoes a lactonization which yields costunolide.  Costunolide can then spontaneously conjugate to glutathione or cysteine.
What are the official names of this protein?
Costunolide synthase, CiCOS, Cytochrome P450 71BL3.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GR47B_DROME
Sequence: MQRDDGFVYCYGNLYSLLLYWGLVTIRVRSPDRGGAFSNRWTVCYALFTRSFMVICFMATVMTKLRDPEMSAAMFGHLSPLVKAIFTWECLSCSVTYIEYCLSLDLQKDRHLKLVARMQEFDRSVLMVFPHVQWNYRRARLKYWYGTVIVGFCFFSFSISLIFDTTRCTCGIPSTLLMAFTYTLLTSSVGLLGFVHIGIMDFIRVRLRLVQQLLHQLYQADDSSEVHERIAYLFEMSKRCSFLLAELNGVFGFAAAAGIFYDFTIMTCFVYVICQKLLEREPWDPEYVYMLLHVAIHTYKVVITSTYGYLLLREKRNCMHLLSQYSRYFSGQDVARRKTEDFQHWRMHNRQAAMVGSTTLLSVSTIYLVYNGMANYVIILVQLLFQQQQIKDHQLTSGKDVDIVGPMGPITHMD
What is the function of this protein?
Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
What are the official names of this protein?
Putative gustatory receptor 47b.
What is the protein family that this protein belongs to?
Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr57a subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUXN_VIBC1
Sequence: MFDFSLEAIVYAKAITLLATVAVVMMWLFYYCYRLKQKNEVIFGTHHAAYIAYSVCIIAWISSNAYFHTDLLPELGASAGMFMAKFANLASFFAFAFAYYFSCQLAAEQRKGKVHRWQQGIFVSLTVYSLFINLRPGLTVEHVDIVGPSQFIIEFGPHTSYFFIGLVSFVVLTLVNLVAMRTNSSKLTLAKTNYMIAGILVFMLSTAVIHLGMTYFMGDFSLTWLPPALSISEMLFVGYALLTSRFYSVKYIAYLALSVLLVCAIFVLPLGAIFIPLTESNQWLIAIPICALIGITWQLLYKKTSRYASFLIYGDKKTPVQQILSLEEDFKLSIDDAMRRLGKLLQIPNDKLRLVTSNYNETFYEEYLSSNRSVLVFDELSEELEYKVSAKRSMKALYDKMSSNNTALVMPLFGQGKSVTHLLISPHKSNNQMFSNEEISAVQTLLTRVQSTIEADRRIRQSRALANSIAHEMRNPLAQVQLQFEALKQHIENHAPVEQITLDIENGQAAIQRGRQLIDIILREVSDSSPEHEPIAMTSIHKAVDQAVSHYGFENEKIIERIRLPQHTDFVAKLNETLFNFVIFNLIRNAIYYFDSYPDSQIEISTKTGPYENTLIFRDTGPGIDETISHKIFDDFFSYQKSGGSGLGLGYCQRVMRSFGGRIECKSKLGTFTEFHLYFPVVPNAPKADTLRTPYFNDWKQNKRSNEHKVAPNVQINNQSPTVLIVDDKEVQRALVQMYLNQLGVNSLQANNGENAVEVFKANHVDLILMDVQMPVMNGFDASQRIKELSPQTPIVALSGESGERELDMINKLMDGRLEKPTTLNALRHVLGNWLNKNTASSACEAERE
What is the function of this protein?
At low cell density, in the absence of AI-1 (autoinducer 1), LuxN has a kinase activity and autophosphorylates on His-471.  The phosphoryl group is then transferred on Asp-771 of the response regulator domain.  The phosphoryl group is transferred to LuxU, and ultimately to LuxO.  At high cell density, in the presence of AI-1, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity.  LuxN phosphatase acts on itself.  As LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO, LuxU transfers phosphate from LuxO to LuxN and finally phosphate is drained from the system.
What are the official names of this protein?
Autoinducer 1 sensor kinase/phosphatase LuxN.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SODC_LAMCR
Sequence: MVKAVCVLKGTTGEVTGTVYFEQESDSAPVKLTGQIIGLAPGLHGFHVHAFGDNTNXXXXXXXXXXXXXXTHAGPTDKDRHVGDLGNVAKIDITDKMLTLNGPLSIIGRTMVIHEKADDLGKGGNDESLKTGNAGGRMA
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: APT_PROM1
Sequence: MDHLKKYITEINDYPKKGIVFKDLNPIYKEPKAWKELMFPLQNLISTKKPDYIAGIESRGFISASALAFKLEIGLITIRKPNKLPGEVIGTNYKLEYGEDRLEIQQNIIEKDSKILLFDDLLATGGTAGAAGKLIKKAGGNLIGYAFLVELTELKGRENLDSNLLVETLIKY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAPR1_CYCAE
Sequence: MDSNKDERAYAQWVIIILHNVGSSPFKIANLGLSWGKLYADGNKDKEVYPSDYNGKTVGPDEKIQINSCGRENASSGTEGSFDIVDPNDGNKTIRHFYWECPWGSKRNTWTPSGSNTKWMVEWSGQNLDSGALGTITVDVLRKGN
What are the official names of this protein?
Aegerolysin Aa-Pri1.
What is the protein family that this protein belongs to?
Belongs to the aegerolysin family.
Protein: NSRR_ECOLC
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKSASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: DNAK_XANAC
Sequence: MGKIIGIDLGTTNSCVSIMDGGKARVIENSEGDRTTPSIVAYTKDGEVLVGASAKRQAVTNPKNTFYAVKRLIGRKFTDGEVQKDISHVPYGILAHDNGDAWVQTSDGKRMAPQEISARVLEKMKKTAEDFLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKNGGDRKIAVYDLGGGTFDVSIIEIAEVDGEKQFEVLATNGDTFLGGEDFDNRVIEYLVDEFNKDQGIDLRKDPLALQRLKDAAERAKIELSSSQQTEVNLPYVTADASGPKHLNIKLTRAKLEALVEDLVKKSIEPCRTALNDAGLRASDINEVILVGGQTRMPKVQQAVADFFGKEPRKDVNPDEAVAVGAAIQGGVLAGDVKDVLLLDVTPLSLGIETMGGVFTKIIEKNTTIPTKASQTFSTAEDNQSAVTVHVLQGEREQARFNKSLAKFDLSGIEPAPRGMPQVEVSFDIDANGILHVSAKDKKTNKEQKVEIKAGSGLSDEEIQRMVADAEANREEDKKFQELVQARNQADGLIHATRTAITEHGSKVGGDVIGKVEAALSDLETAMKGDDKAQIEARTKTLEEAGQSLYAAAAAAEQGGNADAASGNAQASKAADDVVDAEFTEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PDAD_NITMS
Sequence: MLDLVAKKLFLTRGKGIHEDRLTSFEYALRDAGIAGTNLVLISSIFPPKAKLISRKEGLQQIKPGQILFTIYSKNQTNEPHRMCSASVGIAQPKDKDRYGYLSEYEAFGQTETQAGDYAEDIAAQMLASSLGIPFDVDKNWDEKRQQWKISGEIYKTQNITQQTRGDKDGKWTTVFAAAVLLV
What are the official names of this protein?
Pyruvoyl-dependent arginine decarboxylase, PvlArgDC.
What is the protein family that this protein belongs to?
Belongs to the PdaD family.
Protein: PSBA1_TRIV2
Sequence: MTTLLEQRSSANLWHRFGNWITSTENRMYVGWFGVLLIPTALTAAIVFILAFIAAPPVDVDGIREPVSGSLLYGNNIITATVVPTSAAIGLHLYPIWEAASLDEWLYNGGPYQMIVLHFLIAIYAYMGRQWELSYRLGMRPWIPVAFSAPVAAATAVLLIYPIGQGSFSDGMMLGISGTFNFMIVFSPEHNILMHPFHMIGVAGVFGGALFSAMHGSLVTSTLVRETSEVESANTGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVIGIWFAALGISTMSFNLNGFNFNNSILDHQGRTIDTWADLLNRANLGIEVMHERNAHNFPLDLASGEVQPIALAAPAIAS
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1 1, PSII D1 protein 1, Photosystem II Q(B) protein 1.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: RL22_THEKO
Sequence: MSRGRFSYSFQNFDPERMARASGRDLRISPKHSVELLREIRGMMLNDALRYLDDVIAKKRPVPMKRFNDSQGHKPGKGFGPGRYPVKVAKAVKKILLNAKNNAEQKGLDVDRLKIIHAAAHRGPVLRGYIPRAFGRATPFNEQTTHIEIVVEEIRR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CLPX_ORITI
Sequence: MAKKIDNKALSCSFCCKNQNEVKKLIAGFSGFICDECIELCIHLIEEERKSNLAISNYSKLPPKKIYEAINAHVVGQQQAAKILAVAVYIQCIRFEHRELADLVAKSNVLLIGPTGCGKTLIAQTLAKIINVPFAMADATSLTEAGYVGEDVENIILRLLQAADFNVERAQKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKIMEGTIALVPPQGGRKHPQQEFIQIDTTNMLFICGGAFTGIEKIIEARTSQSTIGFEATVKSKHDQDYNQILNNLEADDLTKFGLIPEFLGRLPVIATLSDLNQQSLVDILTKPKNALVKQYQKLFELDGAELIFEEEALVAIAQKALAKKTGARGLRAILECVLLDTMFELSNLKNMQVIITADIVKNNLKPIIKPKLQKKSAKKKVTA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: ABT3B_DANRE
Sequence: MAKRGKSVVRTLEDLTLDSGYGGAADSFRSSSLSLCCSEAHISYAHGGHCWNLTDSMRSRHNSLDTVNTVLAEDGETLECSGHCAKLPELEDVPWSLGEVENALNKEEELRFGTVSADLLARLSALVCRALVRIAREAQRLSLRYGKCTKYEVQSAIKMILSWTISVNCIAASLSALSMYNMSTEDKFSRGKSERCGLVFSVGKFFRWMVDSRVAVRVHEHAAIYLTGCMESLFREVFTRVLNSSVVEKDNGIPKFTLESFEQALSNDSELYGLLLPYQHLTCGKNANGILSLPDSLSLHRNQQCSSKAGDAYSQSEQRTIEQSLLATRVGSIAELSDLVSRAMHYLQPLSIKNHSNGTPLPQKSSLVHWEPEALYTLCYFMHCPQMEWENPNVEPSKVTLQNERPFLVLPPLMEWIRVALAHAEHRRSFSVDSDDVRQAARLLLPGVDCEPRQLKTDDCFCVSRKLDAASTEAKFLQDLGFRMLNCGRTDLVNQAINLLGPGGINSMSEQGMTPLMYACVRGDEAMVQMLLDAGADINSEVPNTVQKFPSVFPETRQATPLTFAVLHQHIPVVQLLLDAGANVEGSLQDGMENYTETPLQLASAAGNFELVSLLLERGADPMIGTMYRNGISTAPHGDMNSYSLAAAHGHRNVFCKLLSQSEKGKADVLSLQEILAEGSDLEERNSLKMEATRTGKAKLKALREAMYHSSEHGYVDITLDIRSLGVPWTLHTWLESLRTCFLQHRRPLIQGLLKEFSSIEEEEYTEELITHGLPLMFQILRASKNEVISQQLAVIFTQCYGPYPIPKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGKPFYAHKVLLFTASNRFKLLLANRPAAENTCIEISHVKYNVFQLVMQYLYCGGTDALHIRNTEVMDLLSASKFFQLEALQRHCEIICAKNINTETCVEIYNHAKFLEAPELSAYIEGYFLKNMAVLIELEPFKQLLYNTPVENCCPDVLHDLEKTLATRIRSIHLSSSKGSIV
What are the official names of this protein?
Ankyrin repeat and BTB/POZ domain-containing protein 3-B, BTB/POZ domain-containing protein 11-B.
Protein: QCR2_HUMAN
Sequence: MKLLTRAGSFSRFYSLKVAPKVKATAAPAGAPPQPQDLEFTKLPNGLVIASLENYSPVSRIGLFIKAGSRYEDFSNLGTTHLLRLTSSLTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGLGLSGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVKRGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLFGIYTISQATAAGDVIKAAYNQVKTIAQGNLSNTDVQAAKNKLKAGYLMSVESSECFLEEVGSQALVAGSYMPPSTVLQQIDSVANADIINAAKKFVSGQKSMAASGNLGHTPFVDEL
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity).  The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity).  May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable).
What are the official names of this protein?
Cytochrome b-c1 complex subunit 2, mitochondrial, Complex III subunit 2, Core protein II, Ubiquinol-cytochrome-c reductase complex core protein 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: KA112_PARVI
Sequence: DEEPKETCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD
What is the function of this protein?
Binds and inhibits voltage-sensitive potassium channels.  Inhibits the vertebrate potassium channel Kv1. 1/KCNA1 with low affinity.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 11.2, Parabutoxin-2, PBTx2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 11 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EBA1_PLAFC
Sequence: MKCNISIYFFASFFVLYFAKARNEYDIKENEKFLDVYKEKFNELDKKKYGNVQKTDKKIFTFIENKLDILNNSKFNKRWKSYGTPDNIDKNMSLINKHNNEEMFNNNYQSFLSTSSLIKQNKYVPINAVRVSRILSFLDSRINNGRNTSSNNEVLSNCREKRKGMKWDCKKKNDRSNYVCIPDRRIQLCIVNLSIIKTYTKETMKDHFIEASKKESQLLLKKNDNKYNSKFCNDLKNSFLDYGHLAMGNDMDFGGYSTKAENKIQEVFKGAHGEISEHKIKNFRKEWWNEFREKLWEAMLSEHKNNINNCKNIPQEELQITQWIKEWHGEFLLERDNRSKLPKSKCKNNTLYEACEKECIDPCMKYRDWIIRSKFEWHTLSKEYETQKVPKENAENYLIKISENKNDAKVSLLLNNCDAEYSKYCDCKHTTTLVKSVLNGNDNTIKEKREHIDLDDFSKFGCDKNSVDTNTKVWECKNPYILSTKDVCVPPRRQELCLGNIDRIYDKNLLMIKEHILAIAIYESRILKRKYKNKDDKEVCKIINKTFADIRDIIGGTDYWNDLSNRKLVGKINTNSKYVHRNKKNDKLFRDEWWKVIKKDVWNVISWVFKDKTVCKEDDIENIPQFFRWFSEWGDDYCQDKTKMIETLKVECKEKPCEDDNCKSKCNSYKEWISKKKEEYNKQAKQYQEYQKGNNYKMYSEFKSIKPEVYLKKYSEKCSNLNFEDEFKEELHSDYKNKCTMCPEVKDVPISIIRNNEQTSQEAVPEENTEIAHRTETPSISEGPKGNEQKERDDDSLSKISVSPENSRPETDAKDTSNLLKLKGDVDISMPKAVIGSSPNDNINVTEQGDNISGVNSKPLSDDVRPDKKELEDQNSDESEETVVNHISKSPSINNGDDSGSGSATVSESSSSNTGLSIDDDRNGDTFVRTQDTANTEDVIRKENADKDEDEKGADEERHSTSESLSSPEEKMLTDNEGGNSLNHEEVKEHTSNSDNVQQSGGIVNMNVEKELKDTLENPSSSLDEGKAHEELSEPNLSSDQDMSNTPGPLDNTSEETTERISNNEYKVNEREDERTLTKEYEDIVLKSHMNRESDDGELYDENSDLSTVNDESEDAEAKMKGNDTSEMSHNSSQHIESDQQKNDMKTVGDLGTTHVQNEISVPVTGEIDEKLRESKESKIHKAEEERLSHTDIHKINPEDRNSNTLHLKDIRNEENERHLTNQNINISQERDLQKHGFHTMNNLHGDGVSERSQINHSHHGNRQDRGGNSGNVLNMRSNNNNFNNIPSRYNLYDKKLDLDLYENRNDSTTKELIKKLAEINKCENEISVKYCDHMIHEEIPLKTCTKEKTRNLCCAVSDYCMSYFTYDSEEYYNCTKREFDDPSYTCFRKEAFSSMIFKFLITNKIYYYFYTYKTAKVTIKKINFSLIFFFFFSF
What is the function of this protein?
Binds to host erythrocytes; may act as bridge between erythrocytes and merozoites.
What are the official names of this protein?
Erythrocyte-binding antigen 175, EBA-175.
Protein: THIG_RHOPS
Sequence: MVKFYDRDISSRLLIGSALYPSPAIMQDAIRDSGAEIVTVSLRRETAGGKAGDQFWSLIRELGVTVLPNTAGCRSVREAVTTAKLARELFATSWIKLEVIADNDTLQPDVVGLVEAAQILIKDGFEVFPYCTEDLSVALRLVDAGCRVIMPWAAPIGSARGITNRDALKLLRDRLPDITLVVDAGLGAPSHAAEAMELGYDAVLLNTAIAKAEDPVAMARAFRLAVDAGRLGYQAGLMGARDFASPSTPVIGTPFWHAVS
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURR_ESCF3
Sequence: MLYLTKIRNAESEFTGNEQKIADFLQAKVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASREKTNATALHLHSSITSDDSLEVIARKLNREKELALEQTCALLDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEILLCAEAARKQGATVIAITSLTDSPLRRLAHFTLDTVSGETEWRSSSMSTRTAQNSVTDLLFVGLVQLNDVESLKMIERSSELTQRLK
What is the function of this protein?
Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc).  Binds to two adjacent inverted repeats within the operator region.  MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
What are the official names of this protein?
HTH-type transcriptional regulator MurR, MurPQ operon repressor.
Protein: CAPP_SHIB3
Sequence: MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDVYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKALWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: DOP_ACIC1
Sequence: MHRVMGIETEYGISVPHQPNANAMAASSQVVNAYAPIGAPAQRQARWDFEEENPLRDARGFEVAREAADPSQLTDEDLGLANVILTNGARLYVDHAHPEYSTPEVTNPRDAVLWDKAGERIMAEAARRAADLPMGWTIQLYKNNTDNKGASYGCHENYLMNRSTPFADIVRHLIPFFVTRQVFCGAGRVGIGADGRGEGFQLSQRADFFEVEVGLETTLKRPIINTRDEPHADPEKYRRLHVIIGDANMSEIATYLKLGTTALVLAMIEDGFLSQDFSVESPVGALRAVSHDPTLRYQLRLHDGRRLTAVQLQMEYLEQARKYVEDRFGTDVDDMTRDVLDRWETTLVRLADDPMQLSRDLDWVAKLSILEGYRQRENLPWSAHKLQLVDLQYHDVRPDRGLYNRLVARGRMNLLVDEAAVRTAMHEPPNDTRAYFRGRCLAKFGAEIAAASWDSVIFDLPGRDSLQRVPTLEPLRGTRAHVGDLLDRCRSATELVAALTGGR
What is the function of this protein?
Displays depupylase (DPUP) activity, removing conjugated Pup from target proteins; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins.  Is also able to catalyze the deamidation of the C-terminal glutamine to glutamate in a variant of the prokaryotic ubiquitin-like protein Pup; however, since Pup from A. cellulolyticus possesses a C-terminal glutamate, this deamidase activity may be of no significance in vivo.
What are the official names of this protein?
Depupylase.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.
Protein: AROD_CLOBB
Sequence: MKRIVQVKNVKIGEGIPKICVPIVGATSKEILDEAEKLKELTLDIVEWRVDFYEEVFDIEKVKDTLSKLTTTLNEVPLIFTFRNKIEGGEREIPIEYYLKLNLEVAKTKLVDLIDVELFIGDDLVKEIVEVAHDNDVKVIISNHDFFKTPCKEEIISRLIKMIQLNGDLPKIAVMPQCEIDVLTLLYATNEVKHKYPNNSIITMSMSGRGIISRIAGEIFGSCLTFGAAKKASAPGQIGVEELNSVLKVLHENI
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: MER_PSEAI
Sequence: MRARSAIFSRTSLSLCSARLLASSQWVPSSSRSSSAISSRLKPSRWADFTKRTRVTSASP
What are the official names of this protein?
Putative mercuric resistance protein.
Protein: SMYD5_MOUSE
Sequence: MAASMCDVFSFCVGVADRARGSVEVRYVDSIKGKGLFATQLIRKGETIFIERPLVAAQFLWNALYQYRACDHCLRALEKAEENAQRLTGKPSQILPHPELCSVRKDLHQNCPHCQVMYCSAECRLAAAEQYHQILCPGPSHDPRHPLNKLQEAWRSVHYPPETASIMLMARMVATVKQAKDKDHWVRLFNHFCSRTANQEQAIVHKLLKGKFKDQLELLLGLFKEALYEEALSLWFTPEGFRSLFALVGTNGQGIGTSSLSQWVHACDALELTPQDREQLDTFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFVLHVTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFNCSCPKCLAEADDPNVTSEEEEEEDEEEGEPEDAELGDEMTDV
What is the function of this protein?
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (PubMed:22921934, PubMed:28250819).  In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (PubMed:22921934).  Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (PubMed:28951459).  Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (PubMed:28951459).  Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28250819).
What are the official names of this protein?
Histone-lysine N-trimethyltransferase SMYD5, Protein NN8-4AG, Retinoic acid-induced protein 15, SET and MYND domain-containing protein 5, [histone H4]-lysine20 N-trimethyltransferase SMYD5.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Protein: MURG_TROWT
Sequence: MSRILLAGGGTAGHVNPLLALADVLKVSGHATFALGTSEGIESRLVPNSGIDFFTIPKLPFPRRTSRHILCFPFKFFSSVKLVRSILIEHKIQVVVGFGGYVAAPAYAAAISLNIPYVVHESNARPGLANLLAAHFAKCVGISVIGALPCGKLVGTPIRRDLTAAASFDPVLAKEKLGLDPVRKLLLVFGGSQGSAKINMHMRAALPRVLKLCDEKNYLWQVLHITGYGDSIDVNMPHYSSVRYMDSMGYALSAADLVVSRAGSSTVAELCTFGIPAIYIPYPFGNGEQRRNVSHMESAARIIQENDLSQIRLEDELLELMTDDERREAMSIAAKRFAICNAAQNTASLIELALSS
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.