PharMolix/UniProtQA huggingface dataset:
Protein: RUVB_LEPBJ
Sequence: MAKSHTLNPEEEFEEESGLRPSLLSEFIGQKEVLNNLTVYVQAAKNRKRALDHVLISGPPGLGKTTLAGIVSNELGTRLTITSAPVITKGADLARLLTSVGENEILFIDEIHTLHKKLEEILYPAMENYMIDLVIGEGVTAQMVQIPLKPFTLVGATTRSGLISEPLKSRFGIQLRLDYYNDEEMKEIVLRSSRILGVKIEDDAALEIGKRSRKTPRIANHLLKRIRDFSEVEGNLSVKKGLCLKAFEKMGIDDLGLDGMDRQILGCMIDRYKGGPVGLKAIAVVVGEEEKTIEDTYESFMVRIGLINRTPAGRVATEKAYRQLKRMQDFSENHGQDPTLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RUTD_KLEVT
Sequence: MMRLNIAPAPWPGAPVVVLSAGLGGGGGYWLAQRAALEAQYQLVSYDHNGTGENAGPLPADYSMATMAQELLSALQAAGITRFALVGHALGALIGLQLALDRPEAVSALVLVNGWLTLSPHTRRCFLVRERLLHAGGAQAWVEAQPLFLYPAEWMAARLPRLEAEDALAISHFQGKENLLKRLQALKQADFSRRAAAIACPTLIVSAADDLLVPASCSRVLQAAIPGSQRVEMPWGGHACNVTDADTFNTILCDGLAAMLPVAREI
What is the function of this protein?
Involved in pyrimidine catabolism.  May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously.
What are the official names of this protein?
Putative carbamate hydrolase RutD, Aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Hydrolase RutD family.
Protein: Y1054_SYNP6
Sequence: MAGKGFGFSLGKMKELADAFKKAQQVQEGAKQVQEDLNNMEIEGQAQGGLVKVWVSGNQEPLRAEIAPEALNEGAEVLSELVAAAMKDAYQKSTAAMKEKMEALTAGLGIPGL
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein syc1054_d.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: LG28_EUBMA
Sequence: VKRPMNAFMVWSQNERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVKEASVRLKHMADYPDYKYRP
What are the official names of this protein?
SRY-related protein LG28.
What are the subcellular locations of this protein?
Nucleus.
Protein: FABPL_MOUSE
Sequence: MNFSGKYQLQSQENFEPFMKAIGLPEDLIQKGKDIKGVSEIVHEGKKIKLTITYGPKVVRNEFTLGEECELETMTGEKVKAVVKLEGDNKMVTTFKGIKSVTELNGDTITNTMTLGDIVYKRVSKRI
What is the function of this protein?
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes.  Binds cholesterol.  Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm.  May be involved in intracellular lipid transport.
What are the official names of this protein?
Fatty acid-binding protein, liver, 14 kDa selenium-binding protein, Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, L-FABP.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_KOSOT
Sequence: MTAIILAAGLGKRMKSEIPKVVHSILGLPMINWVLRAVKKAGIENIIVVTGYKAEIVEALLPEDVKTVRQVKQLGTGHAVMVAQDAVMDDEVIVLTGDAPLISPETLINLYKIRREKDYDVVVASTFQEDPTGYGRIVRENGKLRIIEEKDASEEIKRIKEINSGIYVFKSDFLKDALKKINNNNNQKEYYLTDTVALAEKATAHVIEDPTEVLGVNNRVQLAEIQKIAQKKINERLMLNGITIVDPDTTYISPDVEIGQDTVIEPMTFILGKTKIGNNCLIGPMTRIIDSSIDDSVSIIRSEVEQAIIKSGARVGPFSRLRPGTTLLENTKIGNFVEVKKSTIGRNSKAQHLTYLGDATIGEDVNIGAGTITCNYDGVRKHQTIIENNSFIGSNCSLVAPVKIGEGSVVGAGSVITDDVPPYSLALGRGRQVIKEGRYKNKEKGE
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TTCA_DELAS
Sequence: MFNNPDFSDIATCDLEEPKNSIKIEREQVKLEKRLCREVGRAITDFNMIEEGDKIMVCMSGGKDSYTMLDVLRKLQKRAPVKFELVAVNLDQKQPGFPDHVLPEYFKSIGVDYHIETQDTYSVVKRVVPEGKTTCGLCSRLRRAILYKVADELGCTKVALGHHRDDIVQTLMLNMFYGGRMKGMPPKLVSDDGKHVVIRPLCYVPEKDTVRWAQYQNFPIIPCNLCGSQDGLQRVAVGELLREWDKKFPGRVESMFRAMGHIVTTHMMDPELHDFKNAKATGIADPNGDMAFDHEEMPVSASLPGLQVVQLSS
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_ECOLU
Sequence: MTDVTIKTLAAERQTSVERLVQQFADAGIRKSADDSVSAQEKQTLIDHLNQKNSGPDKLTLQRKTRSTLNIPGTGGKSKSVQIEVRKKRTFVKRDPQEAERLAAEEQAQREAEEQARREAEESAKREAQQKAEREAAEQAKREAAEQAKREAAEKDKVSNQQDDMTKNAQAEKARREQEAAELKRKAEEEARRKLEEEARRVAEEARRMAEENKWTDNAEPTEDSSDYHVTTSQHARQAEDESDREVEGGRGRGRNAKAARPKKGNKHAESKADREEARAAVRGGKGGKRKGSSLQQGFQKPAQAVNRDVVIGETITVGELANKMAVKGSQVIKAMMKLGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEAVMSDRDTGAAAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETENGMITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAQVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFVHVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESFLDKGRGPVATVLVREGTLHKGDIVLCGFEYGRVRAMRNELGQEVLEAGPSIPVEILGLSGVPAAGDEVTVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMTEGEVHEVNIVLKADVQGSVEAISDSLLKLSTDEVKVKIIGSGVGGITETDATLAAASNAILVGFNVRADASARKVIEAESLDLRYYSVIYNLIDEVKAAMSGMLSPELKQQIIGLAEVRDVFKSPKFGAIAGCMVTEGVVKRHNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRTGDVIEVFEIIEIQRTIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_ACIBY
Sequence: MAKATVVKKHNGGTIAQNKRARHDYFIEEKFEAGMSLLGWEVKSLRAGRMSLTESYVIFKNGEAFLFGAQIQPLLSASTHIVPEATRTRKLLLSRRELEKLMGAVNQKGYSCVPLACYWKGHLVKLEIALVKGKQLHDKRATEKERDWQRDKARIFHK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: YD22_SCHPO
Sequence: MNQFPNQPGNFGQNYYKPVQGSIPANSEATNFQQNNSRENKSECELRQNSIAASMSAYPNGMYAGAENHNVENHENYTMVGHDHMEEVYGDDLVNEPRIAYSSDIVATFDGKDFGSNLHVDDTLDQQWAHFAGKQQHPLEPREIPFPVTDPLNSKIEMKQFTNIAAVLRYRGVHSAKKTAFIILDNKGKEFTSITWEKLASRAEKVAQVIRDKSGLFRSDRVVLMYRDCEAIDFVVSLFGCFIAGVVAVPINRFDDYNELSSILTTTSARLALTTDANLKAFQRDLNAKKLHWPKNVEWWKTNEFGGFHLKKKAEMPPLQVPDLAYIEFSRSPIGELHGVVISHRTILHQMNCLAAIHATAPAYESDKLDYLSIDREYTEGLSKSGLFLTYLDLRQAIGLILGVLHTVFSGYTTVWCPQNAVFVPGLWANLATRYRASFMLTDYAGLKTIAYNYQNDPKATLGFSKKHSVDLSSLRMCMVDCLNVDCEFQEIVSDRWLKPLGNQNPRATFVPLLCLPEHGGMVISMKDWIGGEEFMSPKGFKSPRTPENEISEVLLEKEALKLNEVVVLAEDDKARRQSKHPNTIRVGAFWYPFVDATLAIVDPETQVLCLPNIVGEIWVDSPSLSGGFFALPKQTEAIFHARTSFISSDTFQPIPSNQEFLRTGLLGFIRKGKVYVLGLYEDRLQQKVEWVDNGKQDTIFFHHYTSHLVNTIMRKVSKVFDCSAFDIFVNSEHLPVVLLESPAANIPTEANGNQVVINYGLLDLITTECVECLLEDHQVRVYCVLICAPFTLPRVTKNGRQEIGNMMCRRAFEHGTLPFLYVKFAVERAVLNLPVGEDAIDGIWSSYASGIRQNLLSDQELQYSGFIDRSLRYDAKTSVDISSCHTMLQLLQLRVAKNAEDIAYITIDGRGREGKNITWRKFDQRVATIIRYLQKKKYIKPGRVVVLMYTHSEDFVYALYACFYLGLIPIPVPPLDHMRLSEDVPAFLFLIKHYYVSAVLVNSEADTALRAKTTSQHLKQSAMAAKVVLPSFIVTSKISKQTKSIKELNVKLDPICLDPAFPALVWAFWSPDHRLTLTAYNHQTLLSICQIHKETCQMTHKRPLLGHVRSMSGIGFFHTCLMGVFLGTTTYLLSPVDFANNPLLLFQIISKYKIKDTYATFQTLNYIQNQQPTKWPNLSCLENLMIPHDGRISAFYIASLQKYFVKHGLSPYAFSTVYSNCLNPFISTRSYMGAIPTPQLLDLRALRHGLIQPCESADKPYALPLLDSGMVPVSTQLAIVNPDTRELCRVGEYGEIWMRSSANAISFFQSTDPVDMMRFNATNSDGFLGNGYVRTGDLGFLQITSHSMGPNAPVVDMQLLYVLGPIGETFEVNGLSHFPSDIEDTIERSHPRIARGGTAVFQSAGRVVVVIEALGQDFLAAIVPVVINSILDEHQIIADVVAFTSRGNFPRSRLREKQRGKILASWVTGRLRTTQVFYIRGSGEGEFQSSYVPDYNPSLRSTPSVSSRSTLPQRVF
What are the official names of this protein?
Uncharacterized protein C56F8.02.
What is the protein family that this protein belongs to?
To S.pombe SpAC22F3.04.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y4110_SALAI
Sequence: MRSSAPMPRMSRRGRVTIGVLVGVFVLFTLLGWGVQAWTDWLWFGKVDYTEVFSGVLVTRLLLFVTVGLAMAVVVGGNLWLAHRLRPRLRPQSPEQATLERYRMLLSPRLGTWFAVVSVVVGLFAGLSAQSRWSQWLLFRNGGDFGVKDPEFGIDIGFYVFDLPFWRYLLGVAFTAVVLALIGALAVHYVFGGVRLQGVGDRMSNAARAHLSALVAVFVLLKAVAYVLDRRTMLLEYNDGANVYGAGYADINALLPAKEILAYISVVVAIAVLVFSNAWMRNLVWPGISLALLGVSAVAIGGIYPWAVQTFEVKPSARDKEARYIERSIEATRAAFNLGGVETRRYAASNLQPPASLATDTAVVPNARLLDPQLVSETYTQLQQVRGFYDFGPKLDIDRYAVEGKTQDYVVGVREINYGELTAQQSNWINRHTVYTHGYGLVAAPANRVVCGGQPYFVSGFLGDRSQEGCAAPTDQIPASQPRIYYGERMEAGDYAIVGKSNPDANPAEFDRPVGEGDDGAESYYTYTGSGGVEIGSFSRRLLYAIKEQESNFLLSEAVNENSKLLYVRNPRERVEKVAPFLTVDGDPYPAVIDGRVTWIIDGYTTAATYPYAERINLQTETTDELTNRGTFQQARENINYIRNSVKATVDAYDGTVTLYEFDDGDPVLRAWNKAFGGDLIKSKTEIPAELSAHFRYPADLFKVQRNVLTRFHVTSPGDFYSGQDFWQVPNVPDAPDSGQKQPPYYLFTQFPGQEEARFQLTAAVTPNRRQNLAALMSGSYVDGKPQLEVLELPEDTRISGPVQVHQQMTNNAQIRQQLNLLSSNQAQVQYGNLLSLPFGDGMLYVEPVYVKSNQQQAYPLLQKVLLSYGDGGSFVVLADNLADGIKQLVEQGEKAGAPSTPPPSGETPAPTPTPTPTPSSPSVTPPPVTGELADAAQRVQAAIVELRAAQESGDFERYGRALKALDEATAAFEQAAGPGSAATPTGSPSPGG
What are the official names of this protein?
UPF0182 protein Sare_4110.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL18_ECOL5
Sequence: MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: SR1IP_HUMAN
Sequence: MAVPGCNKDSVRAGCKKCGYPGHLTFECRNFLRVDPKRDIVLDVSSTSSEDSDEENEELNKLQALQEKRINEEEEKKKEKSKEKIKLKKKRKRSYSSSSTEEDTSKQKKQKYQKKEKKKEKKSKSKKGKHHKKEKKKRKKEKHSSTPNSSEFSRK
What is the function of this protein?
Possible splicing regulator involved in the control of cellular survival.
What are the official names of this protein?
Protein SREK1IP1, SFRS12-interacting protein 1, SREK1-interacting protein 1, Splicing regulatory protein of 18 kDa, p18SRP.
Protein: S46A3_CHICK
Sequence: MRKVLLVEPVIFIYIFASSLTSPVVQQFIYRKLWEEEYNSTAISSDNSSHCERNKSSPTYVMEKAIQEKTSFFNMQLDLTGAVPSLIVAFIIVANGDHQGRKKSLVLPSIGALIADIFLTIVSYFSWPTSVLFLATFISGLFGSMATFLGGGFAYIADQCHDEKQKTTRIAVIDLIFGVVSGLAGLSSGYFLREMGFTWTFATASLLHVVNIIYITFFLQDTVHISEFQQQAPLSYKEHLKETFSGVYMLFKTAPSKKRILIIVLLFIFMTYLFTMFGGSSLFTLYELDEPLCWTEVYIGYGAAAFTSISLTSFLGVYLFSKCLKDIYIVFIGIFSYIGGIVMAAFAKTTLLMFLVRVPSLFSIMPIPVLRSMLSKVVLPSEQGAVFACIACLEVLTGTISLSVFNVIYAATVAWFSGFSFLLSASLCLIPLGVLCWLLCTSWNGEDLALLVPEEVSSIDSVDS
What are the official names of this protein?
Solute carrier family 46 member 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SLC46A family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CDF5_ARATH
Sequence: MSKSRDTEIKLFGRTITSLLDVNCYDPSSLSPVHDVSSDPSKEDSSSSSSSCSPTIGPIRVPVKKSEQESNKFKDPYILSDLNEPPKAVSEISSPRSSKNNCDQQSEITTTTTTSTTSGEKSTALKKPDKLIPCPRCESANTKFCYYNNYNVNQPRYFCRNCQRYWTAGGSMRNVPVGSGRRKNKGWPSSNHYLQVTSEDCDNNNSGTILSFGSSESSVTETGKHQSGDTAKISADSVSQENKSYQGFLPPQVMLPNNSSPWPYQWSPTGPNASFYPVPFYWGCTVPIYPTSETSSCLGKRSRDQTEGRINDTNTTITTTRARLVSESLRMNIEASKSAVWSKLPTKPEKKTQGFSLFNGFDTKGNSNRSSLVSETSHSLQANPAAMSRAMNFRESMQQ
What is the function of this protein?
Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence (By similarity).  Regulates a photoperiodic flowering response.  Transcriptional repressor of 'CONSTANS' expression.
What are the official names of this protein?
Cyclic dof factor 5, Dof zinc finger protein DOF1.10, AtDOF1.10, H-protein promoter-binding factor 2b.
What are the subcellular locations of this protein?
Nucleus.
Protein: RETST_MACFA
Sequence: MWLPLVLFLAVLLLAVVCKVYLGLFSGKSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFSASRVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGACHTFGENGLEFDTGIHYIGRMEEGSIGRFILDQITEGQLDWVPMSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGLKEKFPQEEAIIDKYIKLVKVVSNGVAHAILLKFLPLPVIQLLDRCGLLTRFSPFLHASTQSLAEVLQQLGASSELQAVLSYIFPTYGVTPRHSAFSMHALLVNHYLKGAFYPRGGSSEIAFHTIPVIQRAGGAVLTRATVQSVLLDSAGKACGVSVKKGHELVNIYCPVVVSNAGLFNTYEHLLPGNARCLPGVKQQLGMVRPGLGMMSVFICLQGTKEDLHLPSTNYYVYHDTDMDQAMERYVSMPREKAAEHIPLLFIAFPSAKDPTWEDRFPGRSSMIMLIPSAYEWFEEWQAELKGKRGSDYETYKNSFVEASMSVAMKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHDLGRLHPRVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKDLGSRIQAQKKKN
What is the function of this protein?
Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol.  Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers.  May play a role in the metabolism of vitamin A.  Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP.  May play a role in adipocyte differentiation.
What are the official names of this protein?
All-trans-retinol 13,14-reductase, All-trans-13,14-dihydroretinol saturase, RetSat, PPAR-alpha-regulated and starvation-induced gene protein.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: RPIA_ECOSM
Sequence: MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKSLGIHVFDLNEVDSLGIYVDGADEINGHMQMIKGGGAALTREKIIASVAEKFICIADASKQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQGVVTDNGNVILDVHGMEILDPIAMENAINAIPGVVTVGLFANRGADVALIGTPDGVKTIVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: NANA_ECO8A
Sequence: MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSEREQVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRREHPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECNKVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSB_BPT2
Sequence: MFKRKSTAELAAQMAKLAGNKGGFSSEDKGEWKLKLDNAGNGQAVIRFLPSKNDEQAPFAILVNHGFKKNGKWYIENCSSTHGDYDSCPVCQYISKNDLYNTDNKEYGLVKRKTSYWANILVVKDPAAPENEGKVFKYRFGKKIWDKINAMIAVDVEMGETPVDVTCPWEGANFVLKVKQVSGFSNYDESKFLNQSAIPNIDDESFQKELFEQMVDLSEMTSKDKFKSFEELSTKFSQVMGTAAMGGAAATAAKKADKVADDLDAFNVDDFNTKTEDDFMSSSSGSSSSADDTDLDDLLNDL
What is the function of this protein?
Single-stranded DNA-binding protein that participates in viral DNA replication, recombination, and repair.  Coats the lagging-strand ssDNA as the replication fork advances.  Stimulates the activities of viral DNA polymerase and DnaB-like SF4 replicative helicase, probably via its interaction with the helicase assembly factor.  Together with DnaB-like SF4 replicative helicase and the helicase assembly factor, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions and mediates homologous DNA strand exchange.  Promotes also the formation of joint molecules.  mRNA specific autogenous translational repressor.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB protein, Gp32, Helix-destabilizing protein.
What is the protein family that this protein belongs to?
Belongs to the Tequatrovirus single-stranded DNA-binding protein family.
Protein: KDSB_RICFE
Sequence: MQHQDVAIIIPSRLSSTRLKQKPLQLIGSTTLIERVFKQVNQANLEHTYVATDSEEIANIIKKVGGKVIFTDSAIPTGTDRTYEAFKLIPNNQNINYIVNVQGDMPFIEPSSILKIIEYLKNSEYDIVTPVVKVDRESVEASSNVTVAVDSAGKALYFSRSLIPNGAEKFLYHVGMYGFRKNALEKFVSLKPTFLEKTERLEQLRVLENGMTIGTCLVENVPISVDTEDDLKKAVKFYENISKLGL
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WIF1_RAT
Sequence: MARRRAFPAFVLRLWSILPCLLLLRADAGQPPEESLYLWIDAHQARVLIGFEEDILIVSEGKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQASGQAEYFYEFLSLRSLDKGIMADPTVNVPRLGTVPHKASVVQVGFPCLGKQDGVAAFEVNVIVMNSEGNPILRTPQNAIFFKTCQQAECPGGCRNGGFCNERRVCECPDGFYGPHCEKALCIPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSATCFNGGTCFYPGKCICPPGLEGEQCELSKCPQPCRNGGKCIGKSKCKCPKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCREGWHGRHCNKRYGASLMHAPRPAGAGLERHTPSLKKAEGRRDPPESNYIW
What is the function of this protein?
Binds to WNT proteins and inhibits their activities.  May be involved in mesoderm segmentation.
What are the official names of this protein?
Wnt inhibitory factor 1, WIF-1.
What are the subcellular locations of this protein?
Secreted.
Protein: COX2_CAERE
Sequence: NNFFQGYNLLFQHSLFASYMDWFHAFNCSLLLGVLVFVTLLFGYLIFSTFYFKSKKIEYQFGELLCSIFPTIILLMQMVPSLSLLYYYGLMNLDSNLTVKVTGHQWYWSYEYSDIPGLEFDSYMKSLDQLNLGEPRLLEVDNRCVIPCDTNIRFCITSADVIHAWALNSLSVKLDAMSGILSTFSYSFPMVGVFYGQCSEICGANHSFMPIALEVTLLDNFKSWCFGTME
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MURA_CROS8
Sequence: MDKFRVQGPGRLSGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDIDTTMKLLSQLGTKVERNGSVWIDASQVNIFCAPYELVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHITGLEQLGAEIKLEEGYVKASVQGRLKGAHIVMDKVSVGATVTIMSAATLAEGTTVIENAAREPEIVDTANFLNTLGAKITGQGTDKITIEGVERLGGGVYRVLPDRIETGTFLVAAAISGGKVMCRNTRPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGVITETIFENRFMHVPELIRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYEGIEDKLRALGANIERIKGE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECF_LACLS
Sequence: MKLKQIELKNFRNYEDLKLDFHPNLNIFLGQNAQGKTNILEAIHFLALTRSHRTSHDKELICWSGQEMKVSGLVEKAHATVPLEVQLSSKGRIAKANHLKENRLADYIGQLKILMFAPENLELVKGSPATRRRFMDIELGQIHAVYLYDSMRYNRALKERNAYLKFDQAKIDKNFLTVLDEQLAEHGNKIMFERKTFIEKLEIHAKKIHEQLTHGLETLKITYNQNVKTDFSKELLSRQDHDIFRHQTTVGPHRDDLQFFINEINVADFGSQGQQRTVALSIKLAEIDLIFEETGEYPILLLDDVMSELDNHRQLDLIETSLGKTQTFITTTTLDHLKNLPENLSIFHVTDGTIEKEKE
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.