PharMolix/UniProtQA huggingface dataset:
Protein: ULAD_ECO7I
Sequence: MSLPMLQVALDNQTMDSAYETTRLIAEEVDIIEVGTILCVGEGVRAVRDLKALYPHKIVLADAKIADAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDAGIQQVVYHRSRDAQAAGVAWGEADITAIKRLSDMGFKVTVTGGLALEDLPLFKGIPIHVFIAGRSIRDAASPVEAARQFKRSIAELWG
What is the function of this protein?
Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
3-keto-L-gulonate-6-phosphate decarboxylase UlaD, 3-dehydro-L-gulonate-6-phosphate decarboxylase, KGPDC, L-ascorbate utilization protein D.
What is the protein family that this protein belongs to?
Belongs to the HPS/KGPDC family. KGPDC subfamily.
Protein: EFTS_HAEI8
Sequence: MAEITASLVKELRDRTGAGMMECKKALVEANGDIELAIDNMRKSGQAKAAKKAGRVAAEGVILARVENGFGVLVEMNCETDFVAKDAGFLGLANEVADFAAANKGTTIEALQAQFEEKRAALVAKIGENMNIRRVAYLDGQVIAQYLHGAKIGVLVAGEGSADELKKVAMHVAASKPEFVNPEDVSAEVVEHERQIQIDIAINSGKPKEIAEKMVEGRMKKFTGEVSLTGQAFVMDPSVSVGDFLKSVNTSVSNFIRLEVGEGIEKKEEDFAAEVAKITGGNA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_PROMS
Sequence: MNKRFNSEDKIILAIDGLDLSQAKLLLEKCPHVKWVKVGLELFVREGPRVIEILKGLNKKIFLDLKFHDIPNTMSAACFQVSKLGVDIISIHASAGLKALKDSKKASLEGATSVSVKPPFVVGITVLTSFSLKDFQTDLDRNNSIEENVLRLAKLSFDAGLDGCVCSPWEVKMLRSNYKNNFELITPGIRLNIDSKDDQNRIMTPHEAIDNGASKLVIGRSISKAIDPNMALIEIFKSIDSD
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: PEN4_ARATH
Sequence: MWRLRTGPKAGEDTHLFTTNNYAGRQIWEFDANAGSPQEIAEVEDARHKFSDNTSRFKTTADLLWRMQFLREKKFEQKIPRVIIEDARKIKYEDAKTALKRGLLYFTALQADDGHWPAENSGPNFYTPPFLICLYITGHLEKIFTPEHVKELLRHIYNMQNEDGGWGLHVESHSVMFCTVINYVCLRIVGEEVGHDDQRNGCAKAHKWIMDHGGATYTPLIGKALLSVLGVYDWSGCNPIPPEFWLLPSSFPVNGGTLWIYLRDTFMGLSYLYGKKFVAPPTPLILQLREELYPEPYAKINWTQTRNRCGKEDLYYPRSFLQDLFWKSVHMFSESILDRWPLNKLIRQRALQSTMALIHYHDESTRYITGGCLPKAFHMLACWIEDPKSDYFKKHLARVREYIWIGEDGLKIQSFGSQLWDTALSLHALLDGIDDHDVDDEIKTTLVKGYDYLKKSQITENPRGDHFKMFRHKTKGGWTFSDQDQGWPVSDCTAESLECCLFFESMPSELIGKKMDVEKLYDAVDYLLYLQSDNGGIAAWQPVEGKAWLEWLSPVEFLEDTIVEYEYVECTGSAIAALTQFNKQFPGYKNVEVKRFITKAAKYIEDMQTVDGSWYGNWGVCFIYGTFFAVRGLVAAGKTYSNCEAIRKAVRFLLDTQNPEGGWGESFLSCPSKKYTPLKGNSTNVVQTAQALMVLIMGDQMERDPLPVHRAAQVLINSQLDNGDFPQQEIMGTFMRTVMLHFPTYRNTFSLWALTHYTHALRRLLP
What is the function of this protein?
Converts oxidosqualene to thalianol.
What are the official names of this protein?
Thalianol synthase 1, AtTHAS1, Oxidosqualene cyclase, Pentacyclic triterpene synthase 4, AtPEN4.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: SLD2_ASPFU
Sequence: MASVAISEIVTQSANLRAELKEWERAFAAQNGGRKAERKDIKKVPEIAAKYKEYSRLKALESSSPNPDDPKSVQLEERPKKRKRAFKDGPDAIQNSSTPRKTAKGALETPSKNRLSSSHPSQVDPYISPTALRRLFSPSTHRTPLKTAIGPTPQRDGKALGLFDLLSESGGSTATPSADRVASVRAANVRTPSKRKTMDTIMEEDEDGEEESPRLGRTPASSGKKWMLSALFATPTTLRYSAMVEDGNHITERNLGPPTDPEGTARDVAGPETPSFLRRSNSARYATSHSANPSLSPIAVRKPPQFVGKGLSALVQGLRDMEEERLEDDLDVLREIEAEQAALNVEVADSQAPAEIIGRHWKKKGQKRTTRRVRMKPVISKPASKPQSASDDENRHQAAGEEPAEPAAVPETQQPRALDAVFSEKQNEEFDDEDDQVSLHTISEPDLDSDPEYGEDIKPVTKSKSFSEKMKEAIGVAQPQPTEDPAKPSKPVIEAEETKKVRARKVNPEAHANYRSLKIRNKNSKGRGAGRFRRR
What is the function of this protein?
Has a role in the initiation of DNA replication.  Required at S-phase checkpoint (By similarity).
What are the official names of this protein?
DNA replication regulator sld2.
What is the protein family that this protein belongs to?
Belongs to the SLD2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KC1D_XENLA
Sequence: MELRVGNRYRLGRKIGSGSFGDIYLGTDIAASEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAAEDAERERREREERLRHTRNPAVRGLPSTASGRLRGTQEVTPSTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTSRQDTSRMSTSQIPSRVTSSGLPSTVHR
What is the function of this protein?
Has no kinase activity.
What are the official names of this protein?
Casein kinase I isoform delta, CKI-delta, CKId, Tau-protein kinase CSNK1D.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: OMPA_YERPE
Sequence: MKKTAIALAVALVGFATVAQAAPKDNTWYTGGKLGWSQYQDTGSIINNDGPTHKDQLGAGAFFGYQANQYLGFEMGYDWLGRMPYKGDINNGAFKAQGVQLAAKLSYPVAQDLDVYTRLGGLVWRADAKGSFDGGLDRASGHDTGVSPLVALGAEYAWTKNWATRMEYQWVNNIGDRETVGARPDNGLLSVGVSYRFGQEDAAAPIVAPTPAPAPIVDTKRFTLKSDVLFGFNKANLKPEGQQALDQLYAQLSSIDPKDGSVVVLGFADRIGQPAPNLALSQRRADSVRDYLVSKGIPADKITARGEGQANPVTGNTCDNVKPRAALIECLAPDRRVEIEVKGYKEVVTQPQA
What is the function of this protein?
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm.  Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
What are the official names of this protein?
Outer membrane protein A, Outer membrane porin A.
What is the protein family that this protein belongs to?
Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: PSIB2_ECOLX
Sequence: MKTELTLNVLQTMSAQEYEDIRAAGSDERRELTHAVMRELDAPDNWTMNGEYGSEFGGFFPVQVRFTPAHERFHLALCSPGDVSQVWVLVLVNAGGEPFAVVQVQRRFAPEAVSHSLALAASLDAQGYSVSDIIHILMAEGGQA
What is the function of this protein?
Inhibition of the induction of the SOS pathway.
What are the official names of this protein?
Protein PsiB.
What is the protein family that this protein belongs to?
To PsiB protein of plasmid F.
Protein: TMCAL_THEP1
Sequence: MEYNPFHNGHLYHLTSARELVRPDYTIAVMSGNFCQRGEPAVIDKFARAEIALRMGIDVVLELPVVFATQDAGGFAFGAVSVLDATGVVTDVVFGSESNDIGFLQRVAQILYEQPDEYQKFLHEELKKGYSFPNARKYALMRYFSMKGWNEEEVLRLEKSNDILGVEYIHSALKIGSNIRFHTIKRVGAEEKDTSFRGRFSSATAIRNLIREERWEEVRDSLPEDSFEILMREINEGRGPVFLENMGDFLLSFFRLKNMEFFERIHGFSEGLEKRFHICARQTGSYQDFLECVKAKRFTFSRIRRLALFSVFEVNKEFVEKSNAKGPQYIRILGFTEKGRKILSLMRKKAKLPIVTNMSLYRKVLEKTDLPVDKQLFFEQIDLDVRTTNFYSMFFPAVEQRCGERDFSIHPIFLRTET
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATL58_ARATH
Sequence: MSYSNSNPENYSAATSSPELKLYQAFIFSVPICFTFIILFLFYLIYLRRSSSDLSSLGMRTTFIPGNSLSTIELGLSKELREMLPIVVFKESFTVMDSQCSVCLGDYQPNDKLQQIPVCKHTFHMDCIDLWLTSHTTCPLCRLALIPSRSRQSQDDPVPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPESQPVNHINDGHEQQCDQDVEGFKEMEEDERNNIGTSSACCSCRTG
What are the official names of this protein?
RING-H2 finger protein ATL58, RING-type E3 ubiquitin transferase ATL58.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IRAD_ECO5E
Sequence: MMRQSLQAVLPEISGNKTSLLRKSVCSDLLTLFNSPHSTLPSLLVSGMPEWQVHNPSDKHLQSWYCRQLRSALLFHEPRIAALQVNLKEAYCHTLAISLEIMLYHDDEPLTFDLVWDNGGWRSATLENVS
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraD.
What is the protein family that this protein belongs to?
Belongs to the GpW/Gp25 family. IraD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TCPW_MOUSE
Sequence: MAAIKIANPGAEVTRSQAALAVNICAARGLQDVLRPTLGPKGALKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASIIAKVAAAQDHVTGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFDVAKTKALEVLDEIKVQKEMKREILLDVARTSLQTKVHAELADILTEAVVDSVLAIRRPGVPIDLFMVEIVEMRHKSETDTQLIRGLVLDHGARHPRMRKQVRDAYILTCNVSLEYEKTEVSSGFFYKTVEEKEKLVKAERKFIEDRVQKIIDLKQKVCAESNKGFVVINQKGIDPVSLEMLAKHNIVALRRAKRRNLERLTLACGGLAVNSFEGLSEECLGHAGLVFEYALGEEKFTFIEDCVNPLSVTLLVKGPNKHTLIQIKDALRDGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNYKHRVQGRVRLGIQAFADALLIIPKVLAQNSGYDLQETLIKIQTKHAESKELLGIDLNTGEPMAAAEAGIWDNYCVKKHLLHSCTVIATNILLVDEIMRAGMSSLRD
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.
What are the official names of this protein?
T-complex protein 1 subunit zeta-2, TCP-1-zeta-2, CCT-zeta-2, Cctz-2.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OAZ1_RAT
Sequence: MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALHCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQCTLTEAKQVTWRAVWNGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLRADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED
What is the function of this protein?
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels.  Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.  Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC.  Stabilizes AZIN2 by interfering with its ubiquitination (By similarity).  Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter (PubMed:8166639).  SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.  Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).
What are the official names of this protein?
Ornithine decarboxylase antizyme 1, ODC-Az.
What is the protein family that this protein belongs to?
Belongs to the ODC antizyme family.
Protein: MT4C_ORYSJ
Sequence: MSCGGSCNCGSCGCGGGCGKMYPDLAEKITTTTTTATTVLGVAPEKGHSEGVGKAAESGEAAHGCSCGSSCRCNPCNC
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable).  Acts as reactive oxygen species (ROS) scavenger.  Possesses superoxide anion and hydroxyl radical scavenging activities in vitro.  Involved in ROS homeostasis during anther and pollen development (PubMed:21297036).
What are the official names of this protein?
Metallothionein-like protein 4C, Class I metallothionein-like protein 4C, MT-1-4b, OsMT-I-4c, OsMT1c.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: VTC2_TOXGM
Sequence: MKFSKQLSAQADLRYLNEYISYKDLKKAIKVITGSDVQVCTVQDVVSNFRQTNALTGSIFRPPESRFQELLNHELDKINSFSKREVEAILDQLAVALVIMWRLHAALTLLRLAPDSPGYAEAQALLKRLEQREQEIRNALVVYPQKRGRATEQDKAGSPSSNPRCRGVSDEPSSSSEERELGAEGDDFSSAGGKTSSRGEGDAKRRQGDEDGGEGEQDDAKRSVAEALILLEKDVLEVEGVLEAQSQEIVFLDSFVRLNFTGFRKITKKYDKHNQSSAASWYMSRVVRQDFMNLNFTLLLTRLARCYVALRSLRRRLGEQQQQSLSISPADDPSKAASVKEDRSTVGSFSQSLGPEGARLSTYKRTGGSDEGEQRREPRFSLAARSRGSRDCREDIKVTKYLIAPDELMKVKVLILKHLPLLAAGGIPMDDSVLCPFENSSQAVAAEDFSAALEAAASLLRTSGTASDKREARQSLGGSRVPTWEVYLDNEEFTYYTNTRTRRDSPDSCRGVAPSRRVVRVRWQGLPSLNSAGRQVALELSRPDSSIADPQEDITTPLASNAPDVASSAFTVILRQKQLLQLLHGLITPSKLLDQLMDEMEASAAGVATGEGANATAASHRTGARGAANRGEGSGGGGGNRGSDDRAVALTKQKRKADMLQVLQTVWDAVQQRGVSPSVRTWFYRTEFMSEDGVAWISVDEDIRFSREMNRTPPANQWIRSETEALSTDDVHPFPWGLLDVSFLVRDNGVALPQHAVQQAKDFHPLVGRDDLEDFVADLRGLSTLTEVPGFSLFAHGTAYFYTPRLQALQARMSGYEQAVHLIPLWLQYTTNAEFDDDASQVFDEATEGGKGKKADRTSVGQSRLGRNQGDSAERGQRAGSPGGLSRPRVCHRGSVIDVVHQGTSASLVHDLQASAQVSPPTSSGVDQLGNSHRPSVSESRHPSAPALSVLASAPSLPMPAPPLLEVSPFQSGARGLLTQPLLDDGDRMAGERQSASRGGAPTPSQSWLLTGARYWRRYCNCFSLSGSAGRRRRSMSCLFPWSQRSSARRIHPVGPRSMVAGGVTSGPSVRVEPKTFFANERTLLQWMNTAVLIATISITLMNFGNPVGRIAGLLMSPVAVFFIGYSFWVYLRRARALERKEPIAYNDKLGPSILVVTLMLSLSAVIALNLLYHEGEAQLPITPQNSSTSTAPSLPPSPHALPLLSQLNVSHSQAAYKAPSAPNATVNAGGYSVADVPAPDFSLSHPATAYAAATALAAAEAAAAAGPVSFAGAPERAVHAHVTEAMTHAASAETAAAEGARVTAGAK
What is the function of this protein?
Accessory subunit of the vacuolar transporter chaperone (VTC) complex.  The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP.  VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation.  The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen.  PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase.  The VTC complex also plays a role in vacuolar membrane fusion.
What are the official names of this protein?
Vacuolar transporter chaperone complex subunit 2, SPX-dependent polyphosphate polymerase VTC subunit 2, Vacuolar membrane polyphosphate polymerase accessory subunit 2, PolyP polymerase.
What is the protein family that this protein belongs to?
Belongs to the VTC2/3 family.
Protein: SSRP_HELHP
Sequence: MPIRVIAKNKKAYFDYEILQSLESGIVLQGSEVKSIRAGRVNLKDSFIKIIRGEAFLFNAHISFLQTTYTHFKPNERRERKLLLHKKEIDKLFGSVSKESLSIVPLNIYFNQKNKIKLCIALVRGKKLHDKRESIKKKMLEREARAHMKSYGKKL
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MK09_MOUSE
Sequence: MSDSKSDGQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVKDQPSDAAVSSKATPSQSSSINDISSMSTEHTLASDTDSSLDASTGPLEGCR
What is the function of this protein?
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death.  Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.  In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2.  In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity.  In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3.  Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1.  In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells.  Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels.  Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption.  When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway.  Participates also in neurite growth in spiral ganglion neurons.  Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).  Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (PubMed:29153991).
What are the official names of this protein?
Mitogen-activated protein kinase 9, MAP kinase 9, MAPK 9, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Colocalizes with POU5F1 in the nucleus.
Protein: PDCL2_MOUSE
Sequence: MQDPNEDTEWNEILRNFGILPPKEEPKDEIEEMVLRLQQEAMVKPYEKMTLAQLKEAEDEFDEEDIKAIEIYREKRLQEWKALKKKQKFGELREISGNQYVNEVTNAEKDLWVVIHLYRSSVPMCLVVNQHLSVLARKFPETKFVKAIVNSCIEHYHDNCLPTIFVYKNGQIEGKFIGIIECGGINLKLEELEWKLSEVGAIQSDLEENPKKGIADMMVSSIRNISIYDSDSSGSDTEAK
What are the official names of this protein?
Phosducin-like protein 2, MgcPhLP, Phosducin-like protein similar 1.
What is the protein family that this protein belongs to?
Belongs to the phosducin family.
Protein: IF1_HYPNA
Sequence: MSKEELIEFEGTVVELLPNATFRVKLENDHEIIAHTAGKMRKNRIRVLTGDKVMVEMTPYDLTKGRITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_PSESM
Sequence: MSRLEQRFAQLKTEGRAVLVTFITAGDPGYDTSLKVLKGLPAAGADVIELGMPFTDPMADGVAIQLATLRALDAGQTLLKTLQMVSEFRVDDQTTPIVLMGYYNPIHRFGVEAFVAQAKEAGVDGLIIVDLPPEHDAELATPAQASGIDFIRLTTPTTDDARLPRVLERSSGFVYYVSVAGVTGAGSATTEHVTEAIARLRRHTSLPISVGFGIRTPEQAAAIARLADGVVVGSAFVDKIATAESPEQAIDGVLTLCAALAEGVRNARVS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: TR119_RAT
Sequence: MMEGHILFFFLVVMVQFVTGVLANGLIVVVHAIDLIMWKKMAPLDLLLFCLATSRIILQLCILFAQLCLFSLVRHTLFEDNITFVFIINELSLWFATWLGVFYCAKIATIPHPLFLWLKMRISRLVPWLILGSVLYVIITTFIHSRETSAILKPIFISLFPKNATQVGTGHATLLSVLVLGLTLPLFIFTVAVLLLIYSLWNYSRQMRTMVGTREYSGHAHISAMLSILSFLILYLSHYMVAVLISTQVLYLGSRTFVFCLLVIGMYPSIHSIVLILGNPKLKRNAKMFIVHCKCCHCTRAWVTSRSPRLSDLPVPPTHPSANKTSCSEACIMPS
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
What are the official names of this protein?
Taste receptor type 2 member 119, T2R119, Taste receptor type 2 member 1, T2R1, Taste receptor type 2 member 19, T2R19.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RSMA_ACIC5
Sequence: MRGGWGRFPPKSREVAAISGKHKPKLGQNFLVSEAACRSIVEALGNLGARTVVEIGPGKGAITELLANRAERLIAIELDRELAPRLRERFARRETVTVIEDDVLRVDLSALARPGEKLLVVGNLPYYMTSEILLHLIRHEAAIERAVVMVQREVADRVAAGPGSRDYGLLSVTAQLHARVEKLLTLPPGAFSPPPEVYSTVLRWTMHSRTDELGVDPTRFTGFLRSCFAQKRKTLGNNLRAAKYEPAAIAGAMQSAGVAAGVRAEELSLEALAALWRTLEDRS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CZCB_ALCSC
Sequence: MAISNKQKAAIAAIVLVGGVATGGVLLSGRSAPEEQGGHSESKGHGDTEHHGKQAAEADHKDDKSHGDGEHHEVKKGPNGGALFSRDGYDVEIGTAESKGEARIRLWVSKSGKAVANGVAATGQLVRATGESQALKFVVSGDALESQQPVAEPHVFDVTANVTLPGSSSPLAVRLSKEEGKIELTADQLAKTGVVVQTAGSAKVQAGVQFPGEIRFNEDKTAHVVPRLAGVVESVPANIGQQVKKGQVLAVIASTGLSDQRSELLAAQKRLDLARVTYDREKKLWEQKISADEDYLSARNALQEAQISVQNAQQKLTAIGASNSSTALNRYELRAPFAGMIVEKHISLGEAVADNANVFTLSDLSSVWAEFVVSAKDVERVRIGEKASINSASSDVKADGTVSYVGSLLGEQTRTAKARVTLTNPQMAWRPGLFVTVDVFGADVEVPVAVKTEAVQDVNGESVVFVAVQGGFVPQPVKVGRTNGKVIEIVEGLKPGARYAAANSFVLKAELGKSSAEHGH
What is the function of this protein?
CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC).  The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
What are the official names of this protein?
Cation efflux system protein CzcB.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
Protein: ZIPA_XANC5
Sequence: MSDMAMIRIGILIAGLLLVAAIFLFGRPKKSPQGRRVDKDEGQPRERREPVISSEFGVEDDAAERAEGVEQSELNLEGQDASGGNEVGKRPNQDFDKIVSLFVAAKAGQVLRGEDVVVAAEKTGLVFGHMNVFHRLVEGHPERGPIFSMASILKPGSFDMANIREMQTPAIAFFLTLPAPMTALDAWEKMLPTVQRMAELLDGVVLDDSRNALGRQRVAHIRDELRAYDRQHQAPPLTKSPRW
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.