PharMolix/UniProtQA huggingface dataset:
Protein: CLPS_ECO8A
Sequence: MGKTNDWLDFDQLAEEKVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RL31B_STAAW
Sequence: MKQGIHPEYHQVIFLDTTTNFKFLSGSTKTSSEMMEWEDGKEYPVIRLDISSDSHPFYTGRQKFAAADGRVERFNKKFGLKSNN
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: H4_ASPOR
Sequence: MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKTFLEGVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PYRH_CLOPE
Sequence: MGTCKYKRVMLKLSGEALAGENGFGIDFNIAMNIAKAVKELVDMGIEVGAVVGGGNIWRGRSGEGMDRTTADYMGMLATSINALALQDSLESLGVDTRVQTAIEMKEIAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFSTDTAAALRAAEIEADVILLAKKVDGVYDKDPHKYDDAKKYDELSYIEVLEQGLQVMDSTATSLCMDNNIPILVFALDNPENIKRVVLGENIGTIVSKK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MALF_SHIFL
Sequence: MDVIKKKHWWQSDALKWSVLGLLGLLVGYLVVLMYAQGEYLFAITTLILSSAGLYIFANRKAYAWRYVYPGMAGMGLFVLFPLVCTIAIAFTNYSSTNQLTFERAQEVLLDRSWQAGKTYNFGLYPAGDEWQLALSDGETGKNYLSDAFKFGGEQKLQLKETTAQPEGERANLRVITQNRQALSDITAILPDGNKVMMSSLRQFSGTQPLYTLDGDGTLTNNQSGVKYRPNNQIGFYQSITADGNWGDEKLSPGYTVTTGWKNFTRVFTDEGIQKPFLAIFVWTVVFSLITVFLTVAVGMVLACLVQWEALRGKAVYRVLLILPYAVPSFISILIFKGLFNQSFGEINMMLSALFGVKPAWFSDPTTARTMLIIVNTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGLFQNFFKITLPLLIKPLTPLMIASFAFNFNNFVLIQLLTNGGPDRLGTTTPAGYTDLLVNYTYRIAFEGGGGQDFGLAAAIATLIFLLVGALAIVNLKATRMKFD
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Maltose/maltodextrin transport system permease protein MalF.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL6_CAMC1
Sequence: MSRIGKQPIAIPSGVDVSVENNVLKFKKGNHLKELDTKGHVDVKIENGHIVFAPKGEDRQSRAYWGTYRALANNIVTGITHGFTRQLEINGVGYKAAAKGKILELSLGFSHLINYELPAGVEASVDKNVITIKGDDKQVVGQVAAQVRGFRPPEPYKGKGVKYLEERIIRKAGKTSKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: FCR3_CANAX
Sequence: MNFKTENSTTPNGDWSQSKAFTNSGSSFPVLNGTCELDQENLALSNSGQPESIFTQDSGLHGIDVAAPSDITDLNNQSGYQYNNNLAHDLYFTGSMEMPTTQHPYITNTNNHLSYSNSSEEFSPIGNNMSPDSTGGANSNNFTSGNKRKASNESFSPLSGHHYGTESGNNNNNNGTSRSSQSSSHKSRKKLLDEKDAALIARDDSELTEEELQMKRKAQNRAAQRAFRERKESKLKELEAKLLASEEERQKLLDELEQIKKQNISIATENEILKHNGMGNINNDVQIGNLSSYGRLQVDKFNFPKTQKDFIEHVLQGTNHQLKDENKDKVYNDNQGHKLLALGAVWDYLQIKAEEADLDFNSIDFNDVMEKLKGNEKCHGYGPAYPLELVNEAIESSLN
What is the function of this protein?
Transcription factor that confers fluconazole resistance in S. cerevisiae by activation of the PDR5 gene.  Can also activate the transcription of S. cerevisiae genes involved in 4-nitroquinoline-N-oxide resistance.
What are the official names of this protein?
Fluconazole resistance protein 3.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LECT_BAUFO
Sequence: SELSFNYPNFQSVEDITFQGGASPRNETLQLTPTDSNGIPIRQRAGHAVYSQPFQLRDTSFYTTFTFVIRTTSNSPADGFAIFIAPPDFPVKRYGGYLGLFEPNTATNTSANKVVAVEFDTWVNTEWKEPRYRHIGIDVNSIVSVRVTRWQDKDVFSRSIATAHVGYDGISKILTAFVTYPDGGNYVLSHVVDLAEIFPGDVRIGFSGATGQYETQYIHSWSFSSTSTNLLRD
What is the function of this protein?
Has metal-independent hemagglutinating activity towards erythrocytes from rabbit and human.  Hemagglutinating activity is inhibited by glycoproteins fetuin, asialo-fetuin, thyroglobulin and azocasein but not by free carbohydrates.  Inhibits ADP- and epinephrin-induced but not collagen-, fibrinogen, thrombin- or arachidonic acid-induced platelet aggregation in vitro.  Has anticoagulant activity in vitro.
What are the official names of this protein?
Lectin, BfL.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ASTD_SHEB9
Sequence: MTHYIQGQWHAGKGHDVASINPANAQTIWTGKTATAEQVNAAVDAAREAQFDWFMLGFDARLAIVEAYRSQLEANKAELAETIAQETGKPQWETATEVGAMIGKIALSAAAYNKRTGTEANDTPAGRAVIRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVIFKPSELTPKVAELMVSLWDKAGLPAGVLNLVQGEVDTGKALASHPQLDGLFFTGSSRTGHFLHQQYAGHPGKILALEMGGNNPLIIKGVQDIKAAVHDILQSAYISSGQRCTCARRLYVEQGEQGDALIAMLAAAVKQIKVGPWNAQPQPFMGSMISETAAKGMVAAQTNLQNLGGVSLVELTHLEAGTGLVSPGLIDVTAIDVLPDEEYFGPLLQLVRYSDFDQAIKLANQTRYGLSAGLLADSREDYDYFLARIRAGIVNWNKQITGASGAAPFGGVGASGNHRASAFYAADYCAYPVASVEADAVSLPATLSPGLSL
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: AUHM_RAT
Sequence: MAAAAAPGALGALSAGRVRLVAACCARLGSAAWARGTAPRRGYSSEVKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE
What is the function of this protein?
Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA).  Can catalyze the reverse reaction but at a much lower rate in vitro.  HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate.  Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site).  Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro.  AREs direct rapid RNA degradation and mRNA deadenylation (By similarity).  Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway.  The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite (PubMed:13783048).
What are the official names of this protein?
Methylglutaconyl-CoA hydratase, mitochondrial, 3-MG-CoA hydratase, AU-specific RNA-binding enoyl-CoA hydratase, AU-binding enoyl-CoA hydratase, Itaconyl-CoA hydratase.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UBIE_PSEOL
Sequence: MNDQRKGDHAEPTTHFGYQDVPESQKAKKVAEVFHSVAAKYDLMNDVLSGGMHRLWKRFTIELSGVRAGNRVLDIAGGTGDLAAKFSRLVGPTGQVVLADINESMLKVGRDRLLDRGVAGNIEFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKDEAIRSMLRVLKPGGR
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: HUTI_CERSK
Sequence: MMILGNLRVATLSDGYGLIPDAAILIEGDRIQWVGPEAHLPPSAAPRHDMGGRLCTPALIDCHTHAVFAGTRAAEFEMRLKGASYAEVAAAGGGIVSTVMATRAASADELLAASLPRIDAMLAGGVGTVEIKSGYGLDIETELRMLRVARRIGQLRKVRVRTSFLGAHAVPPDYRGRPDAYLAEVVLPALKVAQDEGLVDAVDAFCEGIAFSPAQIAHLFAQAHKLRLPVKLHAEQLSNLGGAALAARHDALSADHLEYLDAEGVAALAAAGTVAVLLPGAFYALRETQAPPVAALRAAGVPMAVATDLNPGTSPLGALGLAMNMACTLFRLTPEEALAGTTIHAARALGLSDIGRIAPGFRADLAIWEAEHPAELSWRIGPAPLHVRLHEGEFV
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JBP1_LEIMA
Sequence: MEPDPKKIKLDIFNFPTARETRTPEEVAESYAEAVKSHPFYDNVHSVIDFYDSGTIKDGRGQIIGVVLREALPKYAVSMASELLASAAVRTSLRSMMFGGESPLSGIAGYFDYRGSPVELKSRKTSFTYEHEAAWPAVFPVVDYVSELYRHVAPERWKAQNDAIPDVVRIHGTPFSTLTINSRFRTASHTDVGDFDGGYSCIACLDGHFKGLALAFDDFGINVLMQPRDVMIFDSHHFHSNTEVELSFSGEDWKRLTCVFYYRAALGEPASYAEYQRRLEKSKQDNSFTPVVSNVRVKENGTNLNRPSPVYPICPSPFWVPMVAHCLQHCASEAQCVHDAMTADGSRLAEVMFGEPLSTSDGIPLRGEDKKLKANSDSASRPLSRLGGFSETNLMVSTAVEKKKYLNSEFLSHFISAQLLDMWKQARGKWLELVGREWTHMLALNPERKDFLWKNQSEMNSAFFDLCEVGKQVMLGLLGKEVALPKEEQAFWTMYAVHLNAACAEELHMPHVAMSLRKLNVKLKDFNFGGTRYFKDMPPEEQKRRMERKQRIEEARRHGMSSGAHEKRANWLTNDSFDYQTEDCVVDYAQHKWPPPALHAKEITKNVRTGELPTREGVVRVLVVLPDPQSKLECVDCKLEVPETVRCSCEWERLMSSLAVRRVLAAAQRNLQLPGSVTHGNIEIRFAFHSRLPTDMCDFVVLQHVLSCIPDDVLASAYIRRAAALCTGCVYVVETDVQCRQYYTLKCAARCDYDAVASLFFQQLHRVSYGTKAARVRTKGELESLIPTVCCARYKLQGSPLNTTVHVVSPAPSR
What is the function of this protein?
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU).  DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation.  Also specifically binds to base J-containing DNA (J-DNA).  Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis.  Thymine dioxygenase activity and J-DNA-binding are independent functions (By similarity).
What are the official names of this protein?
Thymine dioxygenase JBP1, J-binding protein 1, Thymidine hydroxylase JBP1.
What is the protein family that this protein belongs to?
Belongs to the TET family. JBP1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y811_SHESR
Sequence: MPSFDIVSEVDEVELRNAVENSRRELSSRFDFRGKDASIEYKDHVVTLTAEDDFQCKQLVDILRTQLSKRNVEPSTMDVDEKSVHSGKTFSLKVRFKQGIETDIAKKIVKMVKDSKIKVQSQIQGDTVRVTGKARDDLQAVMALVRQADLGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein Shewmr7_0811.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: YB8B_SCHPO
Sequence: MGLPVHNQPHKAHSGSPASTFSAALVSSAISNVIGYPLDSIKVRQQTYNFPTIRSCFQNAVKNEGLKGLYRGLTLPLISATLSRSVSFTVYDSLKLTFAHVDPTLRYFISGLGTGTFISLFACPFEYSKLYSQIDMLLRKTNMGRRQETNSKLSVRPPLSSFQSASDIVRRYGFTALWNGYRYHLTRDALGSACYFTIYETFKKNLIANDVKPHFAYAFSGAFCGALSWILVFPVDTAKSIVQRNTLLSIKTPLSSIPWLSFTIYRGIGISLMRSALINSCNFTLFELFRETKVLSK
What are the official names of this protein?
Uncharacterized mitochondrial carrier C29A3.11c.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS3_RHOPB
Sequence: MGQKINPIGLRLGINRTWDSRWYAGKNEYGKLLHEDVKIREILHKELKQAAVARIVIERPHKKCRVTIHSARPGVVIGKKGADIDKLRKKVADITASDVVINIVEIRKPELDATLVAESIAQQLERRVAFRRAMKRAVQSAMRLGAEGIRINCSGRLGGAEIARMEWYREGRVPLHTLRADIDYGVATAFTTFGTCGVKVWIFKGEILEHDPMAQDKRMAEGDNSRPRRDAA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: ACON_YEAST
Sequence: MLSARSAIKRPIVRGLATVSNLTRDSKVNQNLLEDHSFINYKQNVETLDIVRKRLNRPFTYAEKILYGHLDDPHGQDIQRGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPVTVHCDHLIQAQVGGEKDLKRAIDLNKEVYDFLASATAKYNMGFWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTGKMNGWTSPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIEYLEATGRGKIADFAKLYHKDLLSADKDAEYDEVVEIDLNTLEPYINGPFTPDLATPVSKMKEVAVANNWPLDVRVGLIGSCTNSSYEDMSRSASIVKDAAAHGLKSKTIFTVTPGSEQIRATIERDGQLETFKEFGGIVLANACGPCIGQWDRRDIKKGDKNTIVSSYNRNFTSRNDGNPQTHAFVASPELVTAFAIAGDLRFNPLTDKLKDKDGNEFMLKPPHGDGLPQRGYDAGENTYQAPPADRSTVEVKVSPTSDRLQLLKPFKPWDGKDAKDMPILIKAVGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKNVYTGEYKGVPDTARDYRDQGIKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADYDKINPDDRIDILGLAELAPGKPVTMRVHPKNGKPWDAVLTHTFNDEQIEWFKYGSALNKIKADEKK
What is the function of this protein?
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle.  Can also provide minor contributions to the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.  Also plays an essential role in mtDNA maintenance.  May directly protect mtDNA from accumulation of point mutations and ssDNA breaks as a component of mitochondrial nucleoids, or by preventing accumulation of iron citrate thereby alleviating its detrimental effects in mitochondria.
What are the official names of this protein?
Aconitate hydratase, mitochondrial, Aconitase, Citrate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Note=Mainly mitochondrial, small amounts are also detected in the cytosol with a ratio of 94:6.
Protein: RL4_THEAB
Sequence: MAKVSLFNSKGENIGPIDLKDEVFAIEPNFDVIWRYVDMQLTNARAGTASTKTRGEVSGGGRKPWIQKHTGRARQGSIRAPHWRHGGVAHGPKPRVYFKRLNKKMKRLALKSALSLRLKEGNLIVVDEIKFKRPKTKDLREVLKNLGLENQKVLVVLPKKVEEYVNVKISGRNIPGVKVIIADNPGVDRTNIDGLNVYDILNHDKLVLLQGTVQKIEEVLG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: G6PI_SALTY
Sequence: MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDLGPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFNG_HUMAN
Sequence: MKYTSYILAFQLCIVLGSLGCYCQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:16914093, PubMed:8666937).  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation (PubMed:8349687).  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription (PubMed:16914093).  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits (PubMed:8666937).  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading (PubMed:8163024).  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference (PubMed:11112687).  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (PubMed:7729559).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma, Immune interferon.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: DXS_KLEP7
Sequence: MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGVAIAAAKEDKQRRAVCVIGDGAITAGMAFEAMNHAGDIKPDLLVVLNDNEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLVSTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDHTSGVLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSKKFPDRYFDVAIAEQHAVTFAAGLAIGDYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVLFTIDRAGIVGADGQTHQGAFDLSFLRCIPDMVVMTPSDENECRQMLYTGYHYSDGPCAVRYPRGSGTGATLEPLASLPIGKGVVKRQGEKIAILNFGTLLPEAAAVADKLNATLVDMRFVKPLDTALILQLAGEHDALVTLEENAIMGGAGSGVNEVLMAHRRAVPVLNIGLPDYFIPQGTQEEIRADLGLDAAGIEAKIRDWLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: PDXJ_PARD8
Sequence: MTNLSVNINKVATIRNARGGNMPNVLKVAQDCELFGAQGITVHPRPDERHIRYSDVYGLKPLIRTEFNIEGYPCDKFIDLVLKVKPTQVTLVPDAPDAITSNSGWNVKDNFDYLSELVDTFTSQGIRTSIFVGTDLANIELAAKTGTDRIELYTEPYATYYPEDRDKAIAPFVEAAQLAKNLGLGVNAGHDLNLENLAFFNKNIPWLEEVSIGHALICDALYHGLQETIALYKACLNS
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECX_PSEPW
Sequence: MSVVLDTPVAVRRTAMDLLARREHGRVELTRKLRQRGATDELIELALDRLAEEGLLSEARYLESFIRYRSNAGYGPARIREELGQRGLNRGDVDQALRDCGVNWAERLQDAWQRKYAGQRPHDPRSRAQQTRFLAYRGFPMDMIGRLLSGRDLDDY
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NB_SALAI
Sequence: MSDENPLQPPWLNAPPVDPYPYEESHDLRTGPKLHPALDGLLPYVGVWRGRGRGGYPTIEDFDYGQEIRISHDGRPFLCYESRAWLLDEQSRPIRPAGREMGWWRPVLAGDRATGEWEALMTTPTGVMELHLGKRTGTQLEFATDAVVRTPTAKEVTAGHRLFGIVEGALLYAQEMAAVGHGLTPHLSARLIRVGG
What is the function of this protein?
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate.  Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively).  Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
What are the official names of this protein?
Peroxynitrite isomerase, Ferric nitrobindin, Nb(III).
What is the protein family that this protein belongs to?
Belongs to the nitrobindin family.
Protein: LAF1_SCHPO
Sequence: MKSSQTLVYSIPRNVEKDTCAAAIKAYQYLISPPPSPIPNDKVASTVDVPKCSTIPESPKDSIVEPKPTATPVAQLHSKVYDLYRDSPKIWLRRERQWLQRHSPAYRFSTPAAKRPRRQPSSFLDVHASNTRKRGSPDTPDSGHSTPHSKGDVHPGMPQHNTRFKQSSREFSSNTQAIDVANTPYELLPDYSPDMSVLDKRSHPRPLRSEWKGPPLDLSNDENRHLLHPAELQLAATLRLPCLVYLDNKRRIFAEWHNRRTQGLSFRKTDAQRASRVDVNKASRLWKAFHDEGFFDD
What is the function of this protein?
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
What are the official names of this protein?
SWIRM domain-containing protein laf1, Clr6 L-associated factor 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: LUXS_HAEIN
Sequence: MPLLDSFKVDHTKMNAPAVRIAKTMLTPKGDNITVFDLRFCIPNKEILSPKGIHTLEHLFAGFMRDHLNGDSIEIIDISPMGCRTGFYMSLIGTPNEQKVSEAWLASMQDVLGVQDQASIPELNIYQCGSYTEHSLEDAHEIAKNVIARGIGVNKNEDLSLDNSLLK
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.