PharMolix/UniProtQA huggingface dataset:
Protein: FFAR1_MESAU
Sequence: MALSPQLFFALYVSAFALGFPLNLLAIRGAVARARLRLTPNLVYTLHLACSDLLLAITLPVKAVEALASGAWPLPLPLCPVFVLVHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAVRRPRYSWGVCVAIWALVLCHMGLVLGLEAPGGWLNTTSSSLGINTPVNGSPVCLEAWDPNSARPARLSFSILLFFVPLVITAFCYVGCLRALAHSGLSHKRKLRAAWAAGGAFLTLLLCLGPYNASNVASFVNPDLGGSWRKLGLITGSWSVVLNPLVTGYLGASPGRGTVCTTRTQGGTIQK
What is the function of this protein?
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis.  Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1).  May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation.  Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration.  Seems to act through a G(q) and G(i)-mediated pathway.  Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.
What are the official names of this protein?
Free fatty acid receptor 1, G-protein coupled receptor 40.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ARSK_XENLA
Sequence: MIQKCIALSLFLFSALPEDNIVRALSLSPNNPKSNVVMVMSDAFDGRLTLLPENGLVSLPYINFMKKHGALFLNAYTNSPICCPSRAAMWSGLFPHLTESWNNYKCLDSDYPTWMDIVEKNGYVTQRLGKQDYKSGSHSLSNRVEAWTRDVPFLLRQEGRPCANLTGNKTQTRVMALDWKNVDTATAWIQKAAQNHSQPFFLYLGLNLPHPYPSETMGENFGSSTFLTSPYWLQKVPYKNVTIPKWKPLQSMHPVDYYSSYTKNCTAPFTEQEIRDIRAYYYAMCAEADGLLGEIISALNDTGLLGRTYVVFTSDHGELAMEHRQFYKMSMYEGSSHIPLLIMGPRISPGQQISTVVSLVDLYPTMLEIAGVQIPQNISGYSLMPLLSASSNKNVSPSISVHPNWAMSEFHGSDANASTYMLWDNYWKYVAYADGDSVAPQLFDLSSDPDELTNVAGQVPEKVQEMDKKLRSIVDYPKVSASVHVYNKQQFALWKASVGANYTNVIANLRWHADWNKRPRAYEMAIEKWIKSTRQH
What is the function of this protein?
Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity).  Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity).  Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity).
What are the official names of this protein?
Arylsulfatase K, ASK, Glucuronate-2-sulfatase.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Secreted. Lysosome.
Protein: YCF12_TUPAK
Sequence: MNFEVLFQLTALIFVVAAGPLVIVLLASRSNSGL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MELPH_FELCA
Sequence: MGKKLDLSKLTDDEAKHIWEVVQRDFDLRRKEEERLGGLKDRIKKESSQRELLSDAAHLNETHCARCLQPYRLLVAPKRQCLDCHLFTCQDCSHAHPEEEGWLCDPCHLARVVKMGSLEWYYGHLRARFKRFGSAKVIRSLCGRLQGGGGPEPSPGEGSGDSEQTEEDGELDTVAQAQPLGSKKKRLSIHGLDFDADSDGSTQSSGHPPYLSPVPMATDSLQTLTGEPRAKDTSQEAVVLEEADVGAPGCHPHPEEQTDSLSAARQDTLTEPRFPRQSCTTALGLAVTPGPGVISSSERLSSRYPADEGTSDDEDTGADGVASQSLTWRDCAPAESQHLTGHQPTDADREEETLKRKLEEMTSHISDQGASSEEEGSKEEEAGLNRKTSIEDLPGAAPEVLVASGQTSRQETSPRGPQELMQPGRTTDQELLELEDRVAVTASEVQQVESEVSNIKSKIAALQAAGLSVRPSGKPQRRSNLPIFLPRLVGRLGQTPKDPNAEPSDEVKVMTAPYLLRRKFSNPPKSQDKAGDSFDRQSAYRGSLTQRNPNSRKGVANHSFAKPVMTQRP
What is the function of this protein?
Rab effector protein involved in melanosome transport.  Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
What are the official names of this protein?
Melanophilin, Exophilin-3, Slp homolog lacking C2 domains a, SlaC2-a, Synaptotagmin-like protein 2a.
What are the subcellular locations of this protein?
Melanosome.
Protein: RS10_DESRM
Sequence: MKNQKIRIRLKAFDHQMLDQSATKIVDTAKRTGAQVAGPVPLPTEKSIYTILRSPHVNKDSREQFEMRVHKRLIDILEPTPKTVDALMRLDLPAGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RS10_CYTH3
Sequence: MNQKIRIKLKSYDHNLVDKSSERIVRAVKATGAVVSGPIPLPTEKEIFTVLRSPHVNKKSRDQYQLCTYKRLVDIYSTSSKTVDALMKLELPSGVDVEIKV
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: CAV1_SHEEP
Sequence: MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMAEEMNEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLFEAIGKIFSNIRINTQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: SYC_CHLL3
Sequence: MPLVIFNSLGREKQLFEPLHPGVVGIYVCGPTVYGHAHLGHAKSYVSFDVVVRWLRESGYRVKYVQNITDVGHLSDDADEGEDKIARQARLEKTDPMEIAQFYTRSFLDDMDRLGVLRPNISPLATGHIPEQIALVDKLVKRGHAYEVNGNVYFSVESFPGYGKLSGRTDLDAVQSGARVGVRSEKHNPSDFALWKKAEEGHLMQWDSPWGMGYPGWHLECSAMSMKYLGDTIDIHGGGMENRFPHHECEIAQSEAANEKPYVRYWMHNNMVTVNGTKMGKSLKNAVNLKEIFKTVDPLAVRFFILQSHYRSPLDYSDTAVAGSTAGLQKLRETRQRLIEATPGTGLLDAAPFSLRFREAMDDDFNTPVAIAALFDFSKALNTALDRPDGLNASSLEAARELFSTAAVTVLGIMTEDAEGGMHDGGRSAETLDEVMGVLMELRSEARKNKDFATSDLIRDHLLAAGIEIKDTREGASWSKTRH
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_STAAN
Sequence: MAKQDVIELEGTVLDTLPNAMFKVELENGHEILAHVSGKIRMNYIRILPGDKVTVEMSPYDLTRGRITYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_AERHH
Sequence: MSLQTPTESPSSAPRLLVRQLGRRPYQPVWDAMKAFTDSRTPDTPDEFWVVEHDPVYTQGQAGKAEHLLAPGDIPVVQSDRGGQVTYHGPGQLVLYVLVDVRRSKLTVRELVTCLETAIINTLAKSGIEAYAKPDAPGVYVKNQLGAALQTEAKLASLGLRIRKGCSFHGLALNVNMDMTPFLRINPCGYAGMAMTQTSALGGPQSVAEAQAMLVAELASLIGYETITNTEEAA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_STRM5
Sequence: MQASIESTGNLERRLSFSLPEDRLQSHIVGRLGEIARTTRIKGFRPGKVPAKVIEQRFGAQVRGEALDGLLRETFDAAVREHDLRIVGSPRIDKGEEGEFSFVATVEVVPDFGDIDVSKLTVVRHSAEISDADIDQMIENLQNQRRTWAPVSRGAQDGDLVAVETWSQAGEERLPAEGTEKGSIVLGQGMMFETIEKGLVGLAKGEEKTLDVEFPADWRVPVLAGKTVQVTVKVAEVSEPVVPAVDEAFIKSFGVKGGDVEQFRSDIRANLERELKGALMNRLRREVGEQLIAAYASVEMPPRLVENEARAMLAQQVEQIRRNGQNVGEIPADAHEGFKDAAAKRVLVGLLVGEVARVNDLRLEAKRLNETMRLIASTYEEPEQVIEMYRNDPQLMSGLQNRVMEEQVIDWIAERAQHTEEKLSFQDAIRQ
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RS12_CHLT3
Sequence: MPTIQQLVRDGRYTKSFKTASPALDRCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNGIEVTAYIPGEGHNLQEHSIVLIRGGRVKDLPGVRYHIVRGSLDTSGVADRRNGRSKYGAKRPKEGAKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: GLO2_ECO5E
Sequence: MNLNSIPAFDDNYIWVLNDEAGRCLIVDPGDAEPVLNAIAANNWQPEAIFLTHHHHDHVGGVKELVEKFPQIVVYGPQETQDKGTTQVVKDGETAFVLGHEFSVIATPGHTLGHICYFSKPYLFCGDTLFSGGCGRLFEGTASQMYQSLKKLSALPDDTLVCCAHEYTLSNMKFALSILPHDLSINDYYRKVKELRAKNQITLPVILKNERQINVFLRTEDIDLINVINEETLLQQPEERFAWLRSKKDRF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: HRCA_CHLTB
Sequence: MENRIEMSQLRASKKDSKISYVLLMATKLYLESGQPVGSKLLEETYCSDLSSATIRNYFAQLETNGFLRKNHISGGRIPTDLAFRYYADHNAPFLEQEEILAIQQKLTELPEYSKNIVKDLQKASEVLSDILQLPVCFSSPRFESDSVINIQLVAIDDQRVVFVLSTEFGQVFTDVLWLPEQLPENSLKRIEGFLQNYLRKQPSDSLLSQKEEDLGMVLYNEVVVRYLTRYCHFSEEDLYQTGLSRLLKYETFKDPETLAQGLAFFENRKHMCQLLNTYLHKETPTAFIGRELTDIVGNTDPSCAVITIPYYMDRTPLGAFGVLGPMNLPYQQVFGTLSLFTERLKVILTQSFYKFKLSFRRPCPTDPRCSQRPAELTRSSSIKLLPAKELS
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: ZNG1_MOUSE
Sequence: MLPAVKTVEAEEEYAEDCPELVPIETKNQEEENLDFITKIPVTIVTGYLGAGKTTLLNYILTEQHNRKIAVILNEFGEGSAVEKSLAVSQGGELYEEWLELRNGCLCCSVKDSGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITVVDSKYGLKHLTEEKPDGLVNEATRQVALADMILINKTDLVSEEELNNLRTTIRSINGLGKVLETQRSRVHLSNILDLHAYDILSGISLQKKLQHVSTAPHLDQSIVTVTFEVPGSAKEECLNVFIQNLLWEKNVKNKDGHCMEVIRLKGLVSIKDKPQQMIVQGIHELYDLEESLVNWKDDAERACQLVFIGRNLDKDVLQQLFLTAVAEAEEQRTAPGRDGVCPSH
What is the function of this protein?
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them (PubMed:35584702).  Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation (PubMed:35584702).  Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1 (PubMed:35584702).  After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1 to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis (PubMed:35584702).  GTP/GDP exchange is required for release of active METAP1 (PubMed:35584702).
What are the official names of this protein?
Zinc-regulated GTPase metalloprotein activator 1, Cobalamin synthase W domain-containing protein 1, COBW domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Protein: LPXD_CHLTA
Sequence: MSQSTYSLEQLADFLKVEFQGNGATLLSGVEEIEEAKTAHITFLDNEKYAKHLKSSEAGAIIISRTQFQKYRDLNKNFLITSESPSLVFQKCLELFITPVDSGFPGIHPTAVIHPTAIIEDHVCIEPYAVVCQHAHVGSACHIGSGSVIGAYSTVGEHSYIHPRVVIRERVSIGKRVIIQPGAVIGSCGFGYVTSAFGQHKHLKHLGKVIIEDDVEIGANTTIDRGRFKHSVVREGSKIDNLVQIAHQVEVGQHSMIVAQAGIAGSTKIGNHVIIGGQAGITGHICIADHVIMMAQTGVTKSITSPGIYGGAPARPYQEIHRQVAKVRNLPRLEERIAALEKLVQKLEALSEQH
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: CYF_OLIPU
Sequence: MQTRNTLSWIREEITRSISVSLMIYIITWASISSAYPIFAQQNYENPREATGRIVCANCHLANKPVDIEVPQTVLPDTVFEAVVKIPYDMQLKQVLANGKKGALNVGAVLILPEGFELAPPDRISPEIKEKIGTLSFQNYRPNKKNILVIGPVPGQKYSEITFPILAPDPATNKDVHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNATTGGIISKILRKEKGGYEITIVDASNGREVIDIIPRGLELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPLRVQGLLFFLGSVVLAQIFLVLKKKQFEKVQLSEMNF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS20_DESHY
Sequence: MPNIKSAIKRVEIAKVRTIKNAAAKSTLRTTIRRFEESLSTDAETAKLALNKATRALDKASSKGLVHKNTAARKKSRLTKRYAKQFAQVG
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: PVK1_EUBPO
Sequence: GSSGLIPFGRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-1, EubPo-PVK-1.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: END4_CAMFF
Sequence: MKYIGAHVSASGGVSNAPLNAKSIGADAFALFVKNQRQWSAKPLTKSEISSFKTNLKNANISLEHILPHNSYLINLGHPDPQQRKKSIDAFLDEIYRCDLLDLKMINFHPGSHLKEIDENICLSNISSSINYILENSSGIKLVIENTAGQGSNMGFKFEHLGYLVKNSCDKNRIGVCIDTCHLFCSGYDIRSKSAYEKTMDDFGKIVGFEFLSGMHLNDSKCDLASRKDRHESLGKGCIGWSGFENIMNDKRIDEIPLILETIDNSIWADEIIALRNLIKGN
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RRT14_YEAS6
Sequence: MSSSLSQTSKYQATSVVNGLLSNLLPGVPKIRANNGKTSVNNGSKAQLIDRNLKKRVQLQNRDVHKIKKKCKLVKKKKVKKHKLDKEQLEQLAKHQVLKKHQQEGTLTDHERKYLNKLIKRNSQNLRSWDLEEEVRDELEDIQQSILKDTVSTANTDRSKRRRFKRKQFKEDIKGSDFVKDHRYPGLTPGLAPVGLSDEEDSSEED
What is the function of this protein?
Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription 14.
What is the protein family that this protein belongs to?
Belongs to the RRT14 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SLAF5_HUMAN
Sequence: MAQHHLWILLLCLQTWPEAAGKDSEIFTVNGILGESVTFPVNIQEPRQVKIIAWTSKTSVAYVTPGDSETAPVVTVTHRNYYERIHALGPNYNLVISDLRMEDAGDYKADINTQADPYTTTKRYNLQIYRRLGKPKITQSLMASVNSTCNVTLTCSVEKEEKNVTYNWSPLGEEGNVLQIFQTPEDQELTYTCTAQNPVSNNSDSISARQLCADIAMGFRTHHTGLLSVLAMFFLLVLILSSVFLFRLFKRRQGRIFPEGSCLNTFTKNPYAASKKTIYTYIMASRNTQPAESRIYDEILQSKVLPSKEEPVNTVYSEVQFADKMGKASTQDSKPPGTSSYEIVI
What is the function of this protein?
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family.  SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response.  Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2.  Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity).  Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process.  Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway.  May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647, PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation.  In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity).  In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234).  In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).  Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592).
What are the official names of this protein?
SLAM family member 5, Cell surface antigen MAX.3, Hly9-beta, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: FOLD_HALSA
Sequence: MTEIIDGDAVAAQLRADLTGAVETLETAGVTPRLATVLMNDKQASETYVSMKQQDCEEVGIAAEDVRIDPEASADTLFDTVAELNAREDVHGILVQDPTPDHVPDERVLSAVDPAKDVDGFHPENVGKLVGGTPRFKPCTPHGVQKLLAHQGVDPDGAEVVVVGRSNIVGKPLANLLAQKAAGGNATVTICHSHTDDLAAHTRRADVVVAACGVPELIDGDMLSGDPVVIDVGINRVDADTEKGYELVGDVDYDSAEAAASAITPVPGGVGPMTRAMLLYNTLAAASEQTGVAVALP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RS2_BACTN
Sequence: MSRTNFDTLLEAGCHFGHLKRKWNPAMAPYIFMERNGIHIIDLHKTVAKVDEAAEALKQIAKSGKKVLFVATKKQAKQVVAEKAQSVNMPYVIERWPGGMLTNFPTIRKAVKKMATIDKLTNDGTYSNLSKREVLQISRQRAKLDKTLGSIADLTRLPSALFVIDVMKENIAVREANRLGIPVFGIVDTNSDPTNVDFVIPANDDATKSVEVILDACCAAMIEGLEERKAEKIDMEAAGEAPANKGKKKSVKARLDKSDEEAINAAKAAAFIKEDEEA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: YE091_YEAST
Sequence: MWAGKGKKPETGLLSNSFSRERAKGQYFSLESSQSWQLFRSISRSQNCGSHSSFCSIENCECEYGTNAIDALI
What are the official names of this protein?
Putative uncharacterized protein YER091C-A.
Protein: ANR_GINBI
Sequence: MAPQAYPTAGQTTTVCVTGAAGFMASWLVKRLLEKGYIVHATVRDPENKAKVSHLLNLPGATDRLKLFRAELCEDGSFDAAVAGCNGVFHVATPTEFMPKDPENDLIKPAIEGTLNVLKSCTKVDSIKRVVVTSSAATVSINNSSEQNQYIDESCWTDVNFLTSQKPPGWAYPVSKTLAEQAALKYAEEHSLDVVTVIPVLVVGPAVTPTVPSSVELALSLITGDEFKMGALKGMQFVSGSISLVHIDDVCSAQIFLMEKPSAQGRYICFPVNTGIPQLAEFLSKRYPQYKVPTKFDDVPATPKLTISSQKLLDCGFSFKYGIEDIYDQAIEYMKTKGLLTC
What are the official names of this protein?
Putative anthocyanidin reductase, GbANR.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: PTH_MYCA1
Sequence: MAEPLLVVGLGNPGDNYARTRHNVGFMVADLLAARMGSKFKAHKRSGAEIVSGRLAGRSVVVAKPRCYMNESGRQVGPLAKFYSVPPGDIIVIHDDLDLDFGRIRLKIGGGEGGHNGLRSVSNALGSKDFQRVRIGIGRPPGRKDPAAFVLENFTSTERADVPTICEQAADATELLIELGLEPAQNRVHAW
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHM2_METME
Sequence: MKHVLTLLALASVFAVSNQALAYDGQNCKEPGNCWENKPGYPEKIAGSKYDPKHDPVELNKQEESIKAMDARNAKRIANAKSSGNFVFDVK
What is the function of this protein?
Catalyzes the oxidation of primary alcohols including methanol.
What are the official names of this protein?
Methanol dehydrogenase [cytochrome c] subunit 2, MDH small subunit beta, MDH-associated peptide, MEDH.
What is the protein family that this protein belongs to?
Belongs to the methanol dehydrogenase subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Periplasmic side. Note=Periplasmic, but associated with inner membrane.