PharMolix/UniProtQA huggingface dataset:
Protein: NHAA1_PSEA6
Sequence: MNQLQDKDRELAPLERKFNHFICSFEQFFKSQATASITLLLAAIAAMVIANSQWHEGYEEISHMAFSISLGDFAISHSLHTWVNDGLMVLFFFLLGLEIKYECLVGDLKDFRDSSLVIAMAIGGMLLPAGIYAGVALTGVDEALRGWGIPMATDTAFALGILALLGSKAPRSAAVTLSALAIVDDMGAVAVIGLFYTENIHLTSLMYAGLTLGGLFALNVLGFRRPIFYLVGGILLWWFVLQSGVHATAAGILAALAVPTKPYAQSTWFATNMRSVLNRFEKNDRKDKSILEQQDQHELVEQAQDIAAMTTTPIQRWGHVLNRPVSLIILPIFAFINAGVALPDDLSKIFDSVVFIGVASAMVLGKVIGISVFAWIAVKSGFSRLPNGLAFGHVFALACLAGVGFTMSLFIASLGFAGHPELLAQAKLGILAGSVIAAIIGTTLFLMIKHKVHEEPKDERHNKAGLPQTDQE
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PCSK9_PANTR
Sequence: MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSIHTAPPAEAGMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPMLRPRGQPNQCVGHREASIHASCCRAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTAGSTSEEAVAAVAICCRSRHLAQASQELQ
What is the function of this protein?
Crucial player in the regulation of plasma cholesterol homeostasis.  Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.  Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway.  May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.  Can induce ubiquitination of LDLR leading to its subsequent degradation.  Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner.  Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.  Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation.  Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 9, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity).
Protein: SYT_ENTFA
Sequence: MSIHITFPDGAVKPFDSGITTFDVAKSISNSLAKKALAGKFNGVLIDLDRPIVEDGSLEIVTPDHEDALGILRHSSAHLMANALRRLFPNIKFGVGPAIDSGFYYDTDNGESPVTAEDLPAIEAEMMKIVKENNPIVRKEISRAEALELFADDPYKVELITDLPEDEIITVYDQGDFVDLCRGVHVPSTGRIQVFKLLSVAGAYWRGNSDNHMMQRIYGTAFFDKKDLKEFIKMREEAKERDHRKLGKELDLFMVSQEVGSGLPFWLPKGATIRRTIERYIVDKEISLGYQHVYTPIMADVELYKTSGHWDHYHEDMFPPMDMGDGEMLVLRPMNCPHHMMVYKNDIHSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVRPDQIKDEFKRTLELMVAVYADFNITDYRFRLSYRDPNNTDKYFDDDAMWEKAQAMLKAAMDELELDYFEAEGEAAFYGPKLDVQVKTALGMEETLSTIQLDFLLPERFDLTYVGEDGENTHRPVVIHRGIVSTMERFVAYLTEVYKGAFPTWLAPIQATIIPVSVEAHSEYAYEIKERLQAQGLRVEVDDRNEKMGYKIRASQTQKVPYQLVVGDKEMEDATVNVRRYGSKETSVEDLSIFIDSMAAEVHNYSR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_ESCF3
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PETL_SPIOL
Sequence: MFTLTSYFGFLLAALTITSALFIGLNKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: GPI18_YARLI
Sequence: MKHFTTLIVVFVAIKAYLVALALVVPRQYDTSSTLLFPNNRFLSRLVIWDSVFFVSSAERSHLYEHEWAFSWMWSRALGLAGSRDAIAYTAIAVSSLSHLLAALMLRKLTESVFHNKRFAETTALMYILSPAGIFLVAGYTESLFALLSFTGLYLRQRGQYPLAGAVLGASCLLRGNGLLWGIPFLFDLASAIKHNQFNRGVSVVIGGSLVGAVFLYTQYLPWSIFCPERDEWCNYYIPSIYGYVQQRYWNVGFLRYWTANNIPNFLFAAPVLYLMYQSMSTNPSLVPFYTVHAIMGLACVFMWHVQIITRISTCLPTLYWYMAKLAQGYNGHYVVRYIFVWITFQVVMWGAYLPPA
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 2, GPI mannosyltransferase II, GPI-MT-II, Glycosylphosphatidylinositol-anchor biosynthesis protein 18.
What is the protein family that this protein belongs to?
Belongs to the PIGV family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PANB_SHIFL
Sequence: MKPTTIASLQKYKQDKKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVTVADIAYHTAAVRRGAPNCLLLADLPFMAYATPEQAFENAATVMRAGANMVKIEGGEWLVETVKMLTERAVPVCGHLGLTPQSVNIFGGYKVQGRGNEASDRLLSDALALEAAGAQLLVLECVPVELAKRITEALAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYMAEVESGVYPGEEHSFH
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_JANMA
Sequence: MTAQIIDGNLLSQQLRKDVAVRAAALTAKGKQPGLAVILVGADPASQVYVRNKVKACEDNGLYSLLEKYDADMTEAALLARIAALNADPKIHGILVQMPLPKHIDSNKVIEAISPRKDVDGYSVLSAGELLTGLPGFRPCTPYGCMKLIESTGTKLAGKHAVVIGRSNTVGKPMALLLLQANATVTICHSGTADLAYHTRQADVVVAATGRRNTLTAEMIKPGAIVIDVGINRDDNGKLCGDVDFANAKEVASYITPVPGGVGPMTITMLLVNTIEAAERETN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ATPD_BIFA0
Sequence: MQGEASRLADRESRDSFAAKLRESGNDAWEIGNELFTITYVFDHNPRIPRALTDPGRPTEDKVALLNNLLGKQALPLTMEILTDLVGRSWSRAGDIDNAIEDFAVDAMMYQADDEKKTLKVSVQLAQLQSALLNLPVVRSDLSDSQGPLNVRYELLHALIDGADFDRITVRLAEHCTRNPRNRRYLESVQWLINKFSRHMGESMVTVTTATPLSDEQSDKLARIYTKKTGRPVHIHSVVDPTVMGGMRIQVGDEVTDNTVVAQLENLKRKVKAGVSE
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PDXS_NATTJ
Sequence: MNIEKGTETVKKGMAQMQKGGVIMDVTTPEQAKIAEKAGAVAVMALEKVPADIRAGGGVARMADPEVIKKIMDAVSIPVMAKARIGHFVEARILENLGVDYIDESEVLTPADEYYHIDKNKFTVPFVCGARNLGEALRRVGEGASMMRTKGEAGTGNVVEAVRHIRTVMDGIRKVQNLPDDELMTEAKNIGAPYDLIKQVKEEGRLPVVNFAAGGVATPADAALMMQLGADGVFVGSGIFKSGDPEKRAKSIVEATLNYDNYDVLADVSSGLGEAMVGINVSDLEEQERMQNRGW
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: SYCM_BOVIN
Sequence: MLWTRRACGGAWLLRAARGPEPGRSASGARGQGWLQPTGYDTGVKVYNSLTRRKDPLIVSRADAASWYSCGPTVYDHAHLGHACSYVRFDIIRRILSRVFGCTVVMVMGITDVDDKIIRRANEMSVSPASLARLYEEDFKQDMAALKVLPPTAYLRVTEHVPQIVAFIERLIANGHAYCTAKGNVYFDLQSRGDRYGKLVGVAPGPVGEPVDSDKRHTSDFALWKAAKPQEPFWGSPWGDGRPGWHIECSTIASLVFGSQLDIHSGGVDLAFPHHENEIAQCEAFHQCPQWGNYFLHSGHLHVKGGGEKMSKSLKNYVTIKDFLRSTSPDVFRLFCLRSSYRSAIDYSEGALLEARSLLRATAAFVEDARAYLRGQLAGGPIQEDVLWERLGRTKAAVQAALADDFDTVRAVDAVMDLVHHGNRQLKAASEEPRGPRSPAVLGAVVASVEHFFETVGVSLAERQCVPGAGSPAALYSLVEELVRFRLKVRQFALASGEAPGEARRQRLLERQPLLEACDALRRDLAVHGISIKDRSGSSTWELLDPRTEDPKPRS
What are the official names of this protein?
Cysteine--tRNA ligase, mitochondrial, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: AAMA1_AMARI
Sequence: MSDINATRLPIWGIGCNPSVGDEVTALLASGEA
What is the function of this protein?
Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:24613547).
What are the official names of this protein?
Alpha-amanitin proprotein.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: RMUC_RICPR
Sequence: MPSLLLLTTTILLILCVLIIWFYIKTHTLKRQLQFLSEQNLEINNNNRLLNQEKIAYLQKIEQLKCKVEYQEQMIKDSEKIREESFTSAKAALFDLGKDLSKQLIEIHKIENNTARELAEQNITTASRKFNSELERLITMVGALNKDIEQSKSTVDLIKQSLLSPIGAGLLSEITLENILKSSGLRPNLDFIMQYGLTTSDSVKLRPDAIIFLPSGNLMVIDSKASKFLVDSQDNSVNLSKTMNYHLKSLANKDYAENILTTLNKKAHNFNNVITLMFLPTEQAVEKVIAANPEFLQKAWGCNIFPVGPAGLMNMLSFAKFQITDNRRSENYKVIISEVRKLLSSIGTIADYSKKIGYNLQNMVTNYDKFAASFNRNLMSRVKTIQKLGIDSGDKAMPATLERYQIVSSKSEIIEVDAENPTQIEE
What is the function of this protein?
Involved in DNA recombination.
What are the official names of this protein?
DNA recombination protein RmuC homolog.
What is the protein family that this protein belongs to?
Belongs to the RmuC family.
Protein: NAPA_ECOLI
Sequence: MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPLLRMKNGKYDKEGEFTPITWDQAFDVMEEKFKTALKEKGPESIGMFGSGQWTIWEGYAASKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGANMAEMHPILWSRITNRRLSNQNVTVAVLSTYQHRSFELADNGIIFTPQSDLVILNYIANYIIQNNAINQDFFSKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFEDYKAFVAEYTLEKTAEMTGVPKDQLEQLAQLYADPNKKVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFAHRLPADMVVTNEKHRDICEKKWNIPSGTIPAKIGLHAVAQDRALKDGKLNVYWTMCTNNMQAGPNINEERMPGWRDPRNFIIVSDPYPTVSALAADLILPTAMWVEKEGAYGNAERRTQFWRQQVQAPGEAKSDLWQLVQFSRRFKTEEVWPEDLLAKKPELRGKTLYEVLYATPEVSKFPVSELAEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHKARGLRWPVVNGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAEAPDEEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVLFIHPLDAKARDLRRGDKVKVVSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNKLTLDATDPLSKETDFKKCAVKLEKV
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: Y1772_PASMU
Sequence: MSTTQTNQTPIKKYYSINELTALGIGSRTKIDRLAKQGLLKKIKIGGSVRFSADEVNAFIQSTNA
What are the official names of this protein?
Uncharacterized protein PM1772.
Protein: HISX_METJA
Sequence: MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDGVEIEDFKVTDEEIEEAYNSVDYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQVVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYITSPPTKDGKGNPATLIAGDIVGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEVAIDFLAGPSEVLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERKEIILKALENSAILIGDLEECIEFSNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSPVPVGDYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKESLKNIADIVITLAEAEGLFGHAEAVRRRLK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: K319L_PONAB
Sequence: MEKRLGVKPNPASWILSGYYWQTSAKWLRTLYLFYTCFCFSVLWLSTDASESRCQQGKTQFGVGLRSGGENHLWLLEGTPSLQSCWAACCQDSACHVFWWLEGMCIQADCSRPQSCRAFRTHSSNSMLMFLKKFQTADDLGFLPEDDVPHLLGLGWNWASWRQSPPRAALRPAVSSSDQQSLIRKLQKRGSPSEVVTPIVTQHSKVNDSNELGGLTTSGSAEVHKAITISSPLTTDLTAELPGGPKNVSAQPEIPEGLATTPSTQQVKSSEKTQIAVPQPVAPSYSYGTPTPQASFQSTSAPYPVIKELVVSAGDSVQITLPKNEVQLNAYVLQEPPKGETYTYDWQLITHPRDYSGEMEGKHSQILKLSKLTPGLYEFKVIVEGQNAHGEGYVNVTVKPEPRKNRPPIAIVSPQFQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREEKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGKVVEMQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSIATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGNVVITLPTSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTVEVKPDPRKNNLVEIILDINVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELRKQKADFLIFRALEINTVTCQLNCSDHGHCDSFTKRCICDPFWMENFIKVQLRDGESNCEWSVLYVIIATFVIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRTGIKQKGLVLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL
What is the function of this protein?
Possible role in axon guidance through interaction with RTN4R.
What are the official names of this protein?
Dyslexia-associated protein KIAA0319-like protein, Adeno-associated virus receptor, AAVR.
What are the subcellular locations of this protein?
Cytoplasmic granule membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Traffics from the plasma membrane to the trans-Golgi network.
Protein: TBA1_EMENI
Sequence: MREVISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKKEDPDHGFSTFFSETGQGKYVPRTIYADLEPNVVDEVRTGTYRSLFHPENLITGKEDASNNYARGHYTVGKEMIDQVLDKVRRMADSCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQNATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPSYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYSPVISADKASHEANSVQDITMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPKETHAAVATLKTKRTIQFVDWCPTGFKIGICYQPPQQVPNGDLAKVNRAVCMLSNTTAISEAWSALDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVASDSLEEEGEEVEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL7_DICTD
Sequence: MNKEEIIQAIKEMKVIELVELVKALEEEFGVSAAMPVAAVGAPVAGAAAAAPVEEKTTFDVILKDAGANKIKVLKVVREITGLGLKEAKDLVDSTPKPIKEGVSKQEAEEIKAKLEAEGAVVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: FUCM_ECO5E
Sequence: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYADM_XENLA
Sequence: MPVQHRTTVVGNTSTLKSPVGILRILEVIFACVTFSLVVHTGRWTGRIGDLCMFCWCFCFAVSLVILIVEFTGVQNRMPVSWKNFPITFAMYAVLMCLSATVIYPLQYLEDKAYSSEVRNYQIVAIVFSCLTTLAYIIEVSLTRAKPGEVTGYMATTPGLLKVLETFIACIIFVFISDPPLYDRHDALKWCLAVYCICFILSIVVIILCVGECTGWLPCAFNKFLSGYALLAVLMYASAMIIWPIFSFDRKHGGTASRPSNCRSSPGNLYAVCEWDKMVAVAVLTAVNLIAYVMDLVYSARLIFITV
What are the official names of this protein?
Myeloid-associated differentiation marker homolog.
What is the protein family that this protein belongs to?
Belongs to the MAL family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CHMU_SCHPO
Sequence: MSLVNEKLKLENIRSALIRQEDTIIFNFLERAQFPRNEKVYKSGKEGCLNLENYDGSFLNYLLHEEEKVYALVRRYASPEEYPFTDNLPEPILPKFSGKFPLHPNNVNVNSEILEYYINEIVPKISSPGDDFDNYGSTVVCDIRCLQSLSRRIHYGKFVAEAKYLANPEKYKKLILARDIKGIENEIVDAAQEERVLKRLHYKALNYGRDAADPTKPSDRINADCVASIYKDYVIPMTKKVEVDYLLARLL
What is the function of this protein?
Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity).  Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (By similarity).
What are the official names of this protein?
Chorismate mutase, CM.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SET1B_XENLA
Sequence: MSFKEAKPGERGKNPEDHGRKQAASWMNGMEAANQPSTSAEKKSHHWRSYKLIIDPALRKGQQKLYRYDGLSFSMPNSGAPPVDSVRDPRIGRIWTKTKELDLPVPKLKIDEFYVGPVPPKQVTFAKLNDNIRENFLGDMCKKYGEVEEVEILYNPKNKKHLGIAKVIFATVKGAKDAVKHLHNTSVMGNIIHAELDTKGETRMRFYELLVNGYYTPQTLPVGSDLDASPTVNETPQVVEPVKRTKETAVGASVTPNSSTPFSHDTAYSSSRQGTPNSYSQFTPQSQGTPHTPRLGTPFSQDSSYSSRQTTPAFHYGQDSSFKPRRHENKFTDAYNRRPGHHYVHSSGSYRGPENTFNVTRPQAETVQFPRTPPLSHSSGNNKSAFSPYQGSTVFPQTDDNQYPQTSRDMEYRRTGPPTSDSYSDGSLELKLVKEKPEEPPPPEPDSTTEQKASFAQTPERCATPGTPTLEAEMQHDSLDTRIAMLLKEQRTQLHLISSDQNSDSEIRMEGSPISSSSSQLSPIPPYSSSSHYQDVTPSSRPSSTGLEDISPTPLPDSDDDEPIPGTASLCQNSRSASPIDQINQPVRKMETLDNKELVVGDETPTSEKMDEGHPSSGEDMEISDDEVTPSPITSAECAITSSSVIPILPPGFPPLPPPPPPQSGFPMPPPLPPPPPPTHPSVTVPPPPLPAPPGVPPHHILHHPPPYHHFPVMQGEMMNVLGNHWGGMTMSFQMQTQMLSRMMQGQGSYPYHHFMGGSMQFGNQLPYRPFALSAHLSRGQPWPPLPKFDPSVPPPGYEPKKEDPHKATVDGVLQVIVKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERLAKQSLTPVKSGESKDEDKQKTKEHITSSLLESWNKGEGLGFEGIGLGIGLRGAIRLPSFKVKRKEPPDAALAGDQKRIRPSHSVDDEDEESERDRDISGTASDLSKKDADAVNIRRRPARPLDSEGEEEVESEGDDGETSDKEAFEKEDQDAGSVSALSSKKRLYGEKEDEEDETQSSGKEEDLVSEEEDITSVASSRAEMDSSDESDESSEYESSSDSDDEIEEEDDDDEEEELVFEDDQSEELDLGQEDYIETDREEDFFKEDVSECSSPVKAEADMELEDDDVQKLEQDVAHQTAQDTSHLRKKDLDVPLVESKEHKQDTFDKMERLSAVPMQQNVFKEHEKAPSPMNEEEEYIELRLEPVPLVPDNAPPAVQEPMIIRPLTPTGAFGESGPVLKLEEPKLQVNLAHFVAEDEDLYPRTPGRDTAAHSDTEVTFQPGLKVAPSSLPLLQSHNKEEECLLPPEKHTGHLKVTKTLSEEELPRTPGRDILVKSSHLGKSQSTETIPATPGSDAPLTGNSLTLTSPHIPGSPFSYLSQSPGIINSGIPRTPGRDFNFTPIFPESNSIFPSHPSGKKSSVDEPDEKSFKEPTSASLTMNSVPSPIPFASPPRGVPHMDIRLETDDLESSDTQAYLSDKLLSEESECEFTKGQLPSTDESAPSPPFPPTDKRKGPKKPLAAHEFEACVALSEGALGKQLFIGQPDSVSGIKDPAAVPLDFRNDGLSENTVHDPIIQKVPLKELENQWNEVLKEEEEDISKHKKSRNSRLNKLYDEFSTLPSPEYSPPRAMFKPRSEFEEMTILYDIWNGGIDDEDMKYMCITYDRLLQQDNGMDWLNDTLWVYHPPTSVYSPKKKKRDDGLREHVTGCARSEGYYKIDKKDKLKYLINNRSLADEPPIDTQGKSIPAQPQASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKIRFCKSHIHDWGLFAMEPIVADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVVTVESQKKIVIYSKQYINVNEEITYDYKFPIEDVKIPCLCGAENCRGTLN
What is the function of this protein?
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.  H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
What are the official names of this protein?
Histone-lysine N-methyltransferase SETD1B, SET domain-containing protein 1B.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus speckle. Chromosome.
Protein: PCDA8_HUMAN
Sequence: MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGPPKTDLMAFSPCLPPDLGSVDVGEEQDLNVDHGLKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin alpha-8, PCDH-alpha-8.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.