PharMolix/UniProtQA huggingface dataset:
Protein: RLP24_DEBHA
Sequence: MRVYSCHFCSSPVYPLHGIMFVRNDAKEFRFCRSKCHHAFKQRRNPRKLRWTKAFRKAAGKELVVDSTLTFAARRNVPVRYNRDLVATTLKTMARVEEIRQKRERAFYKNRMRGNKDKKLALDRRLVEQNPQLLKIRDVELRRKAERKAAKENAMDEEIEDEEEEIASEDMMSEDEEMESESEAESTKQKVVLKNKKKSKRSN
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  Ensures the docking of DEHA2D15950g/NOG1 to pre-60S particles.  Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles.
What are the official names of this protein?
Ribosome biogenesis protein RLP24.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: PLSB_SALA4
Sequence: MSGWPRIYYKLLNLPLSILVKSKSIPAEPAQELGLDTSRPIMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGALLPRYVFIHGGPRVFTYYTPKEESVKLFHDYLDLHRSNPALDVQMVPVSVMFGRAPGREKGEDNPPLRMLNGVQKFFAISWLGRDSFVRFSPSVSLRRMADEHGTDKIIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASKAIARAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLVPIYIGYEHVMEVGTYAKELRGATKEKESLPQMLKGLSKLRNLGQGYVNFGEPMPLMTYLNQHVPEWRESIDPIEAIRPAWLTPTVNSIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTEQLDCYLDLMRNVPYSTDSTVPAASAGELIAHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLIMPSLMAAIITQHRRISRDALQQHVEALYPMLKAELFLRWEREELASVIDALASEMQRQGLITLQDDELHINPTHSRTLQLLAAGARETLQRYAITFWLLSANPSINRSTLEKESRTVAQRLSVLHGINAPEFFDKAVFSSLVLTLRDEGYISDTGDAEPAETMKIYQMLADLITSDVRLTIESATQGE
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TOPB1_MOUSE
Sequence: MSRNDQEPFLVKFLKSSDNSECFFKALESIKELQSEDYLQIITDEEALKIRENDKSLYICDRFSGTVFDHLKQLGCRIVGPQVVTFCMRHQQCVPRAEHPVYNMIMSDVTVSCTSLDKDKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITKYTDVNMEDFKCPIFLGCIICVTGLNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKGFCQDESIYKAETRVEAKMVPDTSTPTAQSNAESHTLADVSHISNINGSCVNETMFGSTTSKLECSLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDDVRQFWSKSSHRPHVVGAKWLLECFTKGYILPEESYIHTNYQPAGIAVSDQPGNQTAVLDKSGSFSKSALVPAERLQQADEDLLAQYGNDDSTMVEAKLSEALEPEVGPCPGSAHREPCDDSTHISVQEENKSSVSHCILDDSTVREEGLFSQKSFLVLGFSVENKCNIVDIIREHAGKIVSLPSRIVADYAVVPLLGCEVDVTVGEVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSGVTPLEDCVISFSQCVGAERDSLVFLANHLGASVQEFFVRKANAKKGMLASTHLIVKEPTGSKYEAAKKWSLPAVNISWLLETARIGKRADENHFLVDNAPKQEQVLETKIPNGVSSNPDLPAHPDAHLEIHRKKAVTPLDMNRFQSRAFRAVISQQRGQDPTFPPVRQPLTKEPSLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAASQKRKLSSPLSEVIVRNLTVALANSSRNTDSHSASPQLKGAHLEEEETRKPLDSVVVCVSKKLSKKQSELNGVAASLGAEYRWSFDETVTHFIYQGRANDSNREYKSAKERGVHIVSEHWLLECAQEYKHLPESLYPHTYNPKMSLDINTVQDGRLCNSRAPLAVSASKDDGPDHLSVEGNETNTMGTNDKESPLLNGSGRDDCKGALTQALEMRENFQKQLQEIMSATCIVKTPAQKTCMSRSSCNSASSTPDSARSVRSGRSRVLEALRQSRQAVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSDPTQHSELQVEIKMPDDSPSRKPVYHSEIAEQASCVTQAPGHPGSEEPEPPVAERPLIPEPQAPAVASPLAKPPVAPQPADKIETQEETHRKVKKQYVFQMSSLNSQERIDYCRLIKDLGGSVIEKQCSDPSCTHMVVGYPLRNEKYLASMAAGKWVLHRSYLDACKTAGRFVQEEDYEWGSSSILDALPDVTEHQQKLALAAMRWRKRIQQSQESGIVEGAFSGWKAILRVDRPREAGFKRLLQAGGAKVLSGHPEPLLKDATHLFCDFNKLKPDDCRVFIAEATAQNMVCLKTEYIADYLMLESPPCADNYRVSEAALFHNKKGGPGLPQKRKTPAENVVKRPRVH
What is the function of this protein?
Required for DNA replication (By similarity).  Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:14718568).  Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity).  Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters.  Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity).  Induces a large increase in the kinase activity of ATR (By similarity).
What are the official names of this protein?
DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-beta-binding protein 1, TopBP1, DNA topoisomerase II-binding protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX-independent manner (By similarity). Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase.
Protein: COX5A_SAGLB
Sequence: MLGAALRRCAVAATSRAGPRGLLHSAPNPGPAAAIQSVRCYSHGSSETDEEFDARWVTYFNKPDIDAWELRKGINTLVTYDLVPEPKIIDAALRACRRLNDFASTVRILEAVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 5A, mitochondrial, Cytochrome c oxidase polypeptide Va.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5A family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: WHIA_STRT1
Sequence: MSFTIKVKEEIIAASSKDIAELSALIKMSGSVGLTNQGLTLSISTENAKIARHIYQLIENRYRCNPELRHYNKTNLKKNRVYTVFVAENVNDILSDLQLADSFFGFETGIETSIMEDDDAGRSYLRGAFLATGTVRDPEKGRYQLEIFSVYQDHAEDLASLMKKFMLDAKVLQHKNGFVTYLQKAEDIMDFLIVIGAMTSKEIFEEVKIMRETRNDLNRANNAETANIARTISASMKTINNIIKIMDTVGLEILPVELRQIAQLRIANPDYSIQQIADSIEPPLTKSGVNHRLRKINKIADDL
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: TM190_HUMAN
Sequence: MLGCGIPALGLLLLLQGSADGNGIQGFFYPWSCEGDIWDRESCGGQAAIDSPNLCLRLRCCYRNGVCYHQRPDENVRRKHMWALVWTCSGLLLLSCSICLFWWAKRRDVLHMPGFLAGPCDMSKSVSLLSKHRGTKKTPSTGSVPVALSKESRDVEGGTEGEGTEEGEETEGEEEED
What are the official names of this protein?
Transmembrane protein 190.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SERC_HUMAN
Sequence: MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFAKIINNTENLVRELLAVPDNYKVIFLQGGGCGQFSAVPLNLIGLKAGRCADYVVTGAWSAKAAEEAKKFGTINIVHPKLGSYTKIPDPSTWNLNPDASYVYYCANETVHGVEFDFIPDVKGAVLVCDMSSNFLSKPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFALRECPSVLEYKVQAGNSSLYNTPPCFSIYVMGLVLEWIKNNGGAAAMEKLSSIKSQTIYEIIDNSQGFYVCPVEPQNRSKMNIPFRIGNAKGDDALEKRFLDKALELNMLSLKGHRSVGGIRASLYNAVTIEDVQKLAAFMKKFLEMHQL
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
Protein: FPG_RHOE4
Sequence: MPELPEVEVVRRGLQSHAVGAAIEAVEVLHPRAIRRHILGSEDLIGQLTGQTIASAERRGKYLWLVLEPAGVGLVVHLGMSGQMLVQPPTVDWEKHLRIRLALDSGADLRFVDQRTFGGWSISPLVEVDGTMLPESVAHIARDPMDAAFDLESVVKVLRGKHTEIKRAILDQTVVSGIGNIYADESLWRAKIHGNRIAESLTRPKLRELLTAAHSVMGEALDQGGTSFDALYVNVNGESGYFDRSLSAYGQENLPCPRCGAPIKREKFMNRSSFSCPRCQPTPRARRIA
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: G6PI_BUCAT
Sequence: MKNINFNNTQSYQDLKNHFRKIKNIHLRDLFASDLNRFKKFSIIFENEMLIDFSKNRITDETLIYLLNLAKETDVKSGIKLMFSGAKINKTENRSVLHIALRNRTNRPIILNNCNIMLEVNALLEKMKNFSKMVIHGEWKGYTGKSISNVVNIGIGGSDLGPYMVTEALRPYKNHLNMYYVSNIDGTHLTEVLKKINPENTIFLIASKTFTTDETITNAHSAKKWFLHYSQDQSALDKHFFALSANIKNALNFGININNIFKFWDWVGGRFSLWSSAGLSIMLSIGFDNFEKFLDGAHAMDNHFYHTNYKENIPILLALISIWYTNFFGSETEAIFPYDQYMHRFSAYFQQSNMESNGKSINRNGQRINYQTGPIIWGEPGTNGQHAFYQLIHQGTRLIPCDFIAPVFSHNDLNNHHMKLISNFFAQTQALAFGQSRDSILHRLILSKKNQDDIKRILPFKICKGNQPTNSILIRKITPYNLGALIALYEHKIFVQGYILNIFSFDQWGVELGKELSQNIYNYLNINVKNKSYDASTEGLINFYKSFMI
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEBC_SALPA
Sequence: MAGHSKWANTRHRKAAQDAKRGKIFTKIIRELVTAAKLGGGDPDANPRLRAAVDKALANNMTRDTLNRAIARGVGGDEDSNMETIIYEGYGPGGTAIMIECLSDNRNRTVAEVRHAFSKCGGNLGTDGSVAYLFSKKGVISFEKGDEDTIMEAALEAGAEDVVTYDDGAIDVYTAWEEMGKVRDALEAAGLKADSAEVSMIPSTKADMDAETAPKLLRLIDMLEDCDDVQEVYHNGEISDEVAATL
What are the official names of this protein?
Probable transcriptional regulatory protein YebC.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUN62_SCHPO
Sequence: MQTMSSGIARPVLFLTAREGEYVLKDEFQLGSSSRSTPQITGSPLDPNTPVKRLFFMRINIAQFSRWDYPYPREYIEELKKIHGVHHVEENRDVPSILENYRNSKRKSHNFSSSNTPYLKLHRPASRAGAPLINAKSFISSLTFHDNIVRSFQPSIHGKTFVFANHEKSFYWLDVSAANSHSALLKMEFPRASPVCHDINSFTKSPKGLDVIIGFDTGDVLWYDPINFKYLRFNKNGQLNSSSVTAIKWVAGKDSQFLVSFRNGWLVLYDKYRHEQPLHIVVPEKNLKSLYLSSPGTFNILISINHRDDRKLNPVACYAFSKSPINGFCFSPDYQYLALVSERGTLKLFDFVKEHVLDVFHSYFAGLTCVTWSPDGKFIAIGGKDDLVSIYSFPLRKLVARCQGHKSWVTDVIFDAWRCDDDNYRIASVGLDRKLLLWDFSVSAIHRPKSAVYYVNHHSNNSKPAISDFDDVGDLTMGSEIDNSNYVNGDITIHPTLSRSLIPVISPITIYDVDDSPLSSVFFDPDCMITCATNGRIRTWQRP
What is the function of this protein?
Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations.
What are the official names of this protein?
UBP9-binding protein bun62, Binding ubp9 protein of 62 kDa.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell septum. Cell tip.
Protein: THIM_SALPA
Sequence: MQPDLHCRTLAAHTLKHFRALSPLTHCMTNDVVQTFTANTLLALGASPAMVIDPVEARPFAAIANALLINVGTLTASRADAMRAAVESAYDAKTPWTLDPVAVGVLEFRRRFCLDLLSLRPAAIRGNASEILALAGMALGGRGVDTTEAALAALPAAQALARQIDCIVVVTGEIDYVTNSQRTLSIPGGDPLMTRIVGTGCALSAVVAASCALPGAALDNVASACCWMKLAGQAAAERSEGPGSFIPAFLDALYHLDVEAANATN
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RL18_ACICJ
Sequence: MSAVHENEARRRQRLRYQIRLKAHGRPRLSVFRSGKHIYAQVIDDAAGRTLAAASSLDAGLRSALKTGADKAAAAAVGKLVAERAKEAGVTQVVFDRGAYMYHGRVKALAEAARESGLDF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ETF1_FOWPN
Sequence: MNLEILELFNGHIDNIPNILPHQLATLDYLLRTILDHNESVLLFHIMGSGKTIIALLFALIVSKFKKVYILVPNINILNIFTYNLDLATNLINTEYVIENIHIYSTINFYSLNYNDNVVNYNALSKYNDSIFIIDEAHNIFGNNTGELMTIIKNKNKVPFLLLSGSPITNTPITLSNIISIMSDEGINFNDIIIQGKKVFQIILNEKGVSVLKNILKNKISYYELCDTELPSIIFHGKEFLDTKVVYCKMSKLQETDYINVRKLCNNEMFEKNMTNVSLAVLGPLNLANSLELLFVEQDKELYPNLKINDGVLYGDELTKLNISSKFKYFIDTIGNLTGKNFIYFSNSTYGGLVIKYIMLNNGYSEYAGSQGTNPKMINGHLKTFAIVTSKMKSSLEDLLEVYNSPGNDNGEKIMFLFSSNIMSESYTLKEVRNIWFMTIPDTFSQYNQILGRSIRKFSYKDVSKPVNVYLLATVYSDFNDTITSLDDYSIDDINTLPFDIKKLLYLKFKTKETKRIYSILKDLSINYRSSPHPYITDVVLGELVRQFFYHNSRVSINDAKLFKMVNSIFKSKEKTQKYIEKITDDHFFVTNKVFEKSLLYKHKNDIIVVPFNLLFTEYSWMINFRKELNVVV
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from early gene promoters.  Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase.  ETF heterodimer binds to early gene promoters (By similarity).
What are the official names of this protein?
Early transcription factor 70 kDa subunit, ATP-dependent helicase VETFS, ETF small subunit.
What is the protein family that this protein belongs to?
Belongs to the helicase family. VETF subfamily.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle.
Protein: YHFS_BACSU
Sequence: MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQVDEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGTMYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQRSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSGIADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVTPDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYEAKRRPDCQYAVAAIGSGGGIGLALLFEVLA
What is the function of this protein?
May be involved in fatty acid metabolism.
What are the official names of this protein?
Putative acetyl-CoA C-acetyltransferase YhfS.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
Protein: GCH4_BURM7
Sequence: MNLMNPEFAMPDVQSTVDTRQMPIQRVGVRAVRHPLTVRTAEGETQATVGTWNLDVHLPADQKGTHMSRFVALLEERGGPLTADAFRTMLATMLEKLEARAGRIEVSFPYFVNKTAPVSGVRSLLDYEVTLTGDVRDGLTRVFAKVLVPVTSLCPCSKKISQYGAHNQRSHVTIDAELAADVPVEDLIRIAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDVARRLDADERIVAYVLEAENFESIHNHSAYALIERDKRRGA
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: NFI_CITK8
Sequence: MDLASLRAQQIELASSVIREDRLDNDPPDLIAGADVGFEQGGEVTRAAMVLLTYPALELVEYKVARIATTMPYIPGFLSFREYPALLAAWEQLSQKPDLVFVDGHGISHPRRLGVASHFGLMMDVPTIGVAKKRLCGKFEPLSAEPGALAPLMDKGEQLAWVWRSKARCNPLFIATGHRVSTDSALAWVQRCMQGYRLPEPTRWADAVASERPAFVRWQANHR
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_STRPF
Sequence: MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTISDAEEMIKDASGDPELEEMAKEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDQKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKMDEVIDALVMYDQTKKLESLNN
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMN6_ECO45
Sequence: MSQSTSVFRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAAAQAQENINQSPWAERINVHTADILQWITQQTVRFDLIISNPPYYQQGVECATPQREQARYTTTLDHPSLLTCAAECITEEGFFCVVLPEQIGNGFTELALSMGWHLRLRTDVAENEARLPHRVLLAFSPQAGECFSDRLVIRGPDQNYSEAYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBPE_MACFA
Sequence: MAGRGGRALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLRNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSNPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAVGVDFELESFSERKEEEKEELMEWWKMMSETLNF
What is the function of this protein?
Sorting receptor that directs prohormones to the regulated secretory pathway.  Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
What are the official names of this protein?
Carboxypeptidase E, CPE, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.
Protein: APT_DROPS
Sequence: MSQVSAEDKLDYVKSKIGEYPNFPKEGILFRDIFGALTDPKACVYLRDLLVQYIRQSQPEVEVIVGLDSRGFLFNLLLATELGVGYTPIRKKGKLAGEVVSVEYQLEYGSDTFELQRTAIQPGQKVVIVDDLLATGGSLLAASELVRKVGGVVLESLVVMELVGLDGRKKLDCKVHSLIKY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_CHLP8
Sequence: MARKSIIARNERRKELVEKYAAKREELKKAGDYEALRKLPRDSSATRVRNRCVLTGRGRGNYEKFGLCRNMFRKLALEGKLPGVRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: GLYA_ECO57
Sequence: MLKREMNIADYDAELWQAMEQEKVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLEPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQVAKNAKAMVEVFLERGYKVVSGGTDNHLFLVDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRVGTPAITRRGFKEVEAKELAGWMCDVLDSINDEAVIERIKGKVLDICARYPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PERC_ANOGA
Sequence: MLPKGVLLFLVLIVLVQHFATVQTTNAIERPSAPSSQCTSSHESCVLRVMCEVEPRARTTLVPCLTADGLEGVCCSVAKEGKQRKKRSLPFELSQELFQNAVGEGHRVYTRKLANIDHHREVMRGGSVDTLVRQFHAPPGEPLGAEDPTAYEDMFVARSFANALNLSVAERLDLPELTLDPALRRKRCLPPRSCDPHARYRSLDGSCNNPVPARSSWGAAGYPFERLLPPAYEDGVWAPRVHSSVSGRLLASARDISVAVFPDVDRRDRKFNLLLMQFGQFMSHDFTRSASVRIGQEEVQCCNAEHSGALRGEQAHFACMPIAVSPADPFYSRFGIRCLNFVRLALARDGKCRLGYGKQLNRVTHFIDGSAVYGSNEALAASLRTFEGGRLRSSFPTGEELLPFARTRAACEPWAKACFRAGDDRVNQIVSLTEMHTLFLREHNRVATALAALNRHWDDERLYQETRRIVGAVMQKIFYNEYLPSIVGHSKARQYGLLDSHGEQTDFYSPDVKPAVFNELSGAAFRFGHSTVDGAFLIQHRHRRTELVPIQEVFLNPSRLLQRSFFDDFLFSLMDQPQQQLDDSITFGLTRLLFAGRNPFGSDLASLNIQRGRDHALRPYNDYRSWAGLERLTSFEQFGPVGARLASVYEFPDDVDLWVGGLLEPPTQDGALFGETFAAIISEQFARLKFGDRYYYTNGPRTNPGFFTGEQLRELSKVSLASVICANLDQADGFSAPRDAFRQPSEHNPPVPCQTLVGMDLSAWRGH
What is the function of this protein?
Involved in the formation of a rigid and insoluble egg chorion by catalyzing chorion protein cross-linking through dityrosine formation and phenol oxidase-catalyzed chorion melanization.
What are the official names of this protein?
Chorion peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. XPO subfamily.
What are the subcellular locations of this protein?
Secreted. Note=In the chorion layer of the mature eggs.
Protein: TRUB_CUTAK
Sequence: MNTLQSGVLVVDKPAGVTSHQVVGRVRRLMGTRKVGHAGTLDPMASGVLVVGVNRATRLLGHLSLHDKDYTATVRLGVGTVTDDAEGDVTVTTDASAIDDRAIHAAMVRQTGEIQQVPAAVSAIKVNGRRAYAKVRAGEDVVLRPRAVTVSRFEAIAIRRHGQVIDVDVEATCSSGTYVRALARDVGADLGVGGHLTALRRTRVGPFDLTAACVDIFAQDAVTPTPMTMAEAAALSFPVVHVTADQAAAIRVGRRLSFTVPAEVTAIIAETGELLALYRPDDEKDGQSRAICVLV
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.