PharMolix/UniProtQA huggingface dataset:
Protein: PSB2_HUMAN
Sequence: MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
What is the function of this protein?
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit beta type-2, Macropain subunit C7-I, Multicatalytic endopeptidase complex subunit C7-I, Proteasome component C7-I.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.
Protein: ACT6_SOYBN
Sequence: MADAEDIQPLVCDNGTG
What is the function of this protein?
Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
What are the official names of this protein?
Actin-6.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: UVRC_RHOOB
Sequence: MPDPSTYRPATGTIPVDPGVYKFRDPHGRVIYVGKAKSLRSRLNSYFADVSTLHPRTRQMVTTAGSVEWTVVSTEVEALQLEYNWIKEFDPRFNVRYRDDKTYPVLAVTLNEEYPRLFVYRGPRRKGVRYFGPYSHAWAIRETLDLLLRVFPARTCSAGVFKRHNQIGRPCLLGYIDKCSAPCVGRVSAAEHRKIVEDFCDFLSGRTDKLVRQLEARMQQASEELDFETAARLRDDVGALRRALEKQAVVLGDGTDADVAAFATDELEAAVQVFHVRGGRVRGQRGWVVEKAGDVIDWAAVDSAAGSDLPLLVEQFLTQFYGEQAALSGAADQEAGSSGVPREVLVPVLPPDAEQVQEWLSGLRGSAVRLRVPQRGDKKALAETVQRNAMEALQQHKLRRAGDFTSRSAALQGIQEALDLDSAPLRIECVDISHVQGTDVVASLVVFEDGLPRKSDYRHYAIKEAAGDGRSDDVASIAEVTRRRFLRHNRDVGVLRAEAAGADGDQASDTDGDQVSDTDGDQVSGGDGGDLAPEAAIDPQTGRPRRFAYPPNLYVVDGGAPQVAAASAVLDELGITDVAVIGLAKRLEEVWVPGEEDPVILPRTSESLYLLQRVRDEAHRFAITFHRSKRSRRMTASALDSVRGLGETRRKALVTHFGSVAKLKQASVEEITAVPGIGTATAKAVLTALGAEEPSADVAGVGDDEPDRTGPVTAERNGADLPREPVGQHGPAAQSASQRTGVE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBN_KLEP7
Sequence: MELTFLGTSAGVPTRTRNMTSIILNLQQPTRAEMWLFDCGEGTQHQFLHTPYHPGKLNKIFITHLHGDHLFGLPGLLCSRSMQGNSLPLTLYGPKGLKEFVETALRLSGSWTDYPLTIIEVGPGLVFDEEGYRVTAYPLSHPVECYGYRIAQHDKPGTLDAAQLIADGVPPGPLFHQLKRGQRVELADGRVIDGSRYLGPSTPGKTLAIFGDTAPCPQALEMARGADVMVHETTLEQAMAEKANSRGHSSSQQTAALAKEAGVGTLIATHFSSRYDAEGCLRMLAECREIFPNTLLAEDFMVYKMA
What is the function of this protein?
Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.
What are the official names of this protein?
Ribonuclease BN, RNase BN, Ribonuclease Z homolog, RNase Z homolog.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family. RNase BN subfamily.
Protein: MNMG_METFK
Sequence: MRFSEKFDVIIVGGGHAGTEAALASARMGQKTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAAATDEGGIQFRILNSSKGPAVRATRAQADRVLYKAAIRRRLENQPNLWLFQQAVDDIILEGERVAGVVTQLGLRFESKAVVLTAGTFLAGLVHVGLANYQAGRAGDPPAVSLAARLREIGLPAGRLKTGTPPRIDGRTIDYSVMAEQPGDSPVPVFSFLGSAEQHPAQLPCWITFTNEKTHDIIRSGLDRSPMYTGVIEGVGPRYCPSVEDKIHRFADKDSHQVFLEPEGLTTNEIYPNGISTSLPFDIQYQLVRSIKGLENAHILRPGYAIEYDYYDPRGLKSSLETKAIRGLFFAGQINGTTGYEEAAAQGLLAGANAALYAQEKDAWWPTRDQAYLGVLVDDLITRGVSEPYRMFTSRAEYRLMLREDNADMRLTEAGRKLGLVDDVRWEAFQRKQEAIEREQQRLRRTFIHPQHVPQEQLQQVFGKVLEREYSMFELLRRPEVSYEALLSLPQAGEGEADPQVRQQLEIVAKYQGYIDRQAEEIERLKESEHYRLPLNMDYSEVHGLSIEVQQKLNKQKPETIGQAGRISGVTPAAVSLLLVHLKRKSRKAGNTADQVA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTG_CUPPJ
Sequence: MRMAVTQNPWQGRVDSGEVGDTTRLFRIVNTLESSEAKTLGGSPVLLGFGCDAGVLRNQGRAGAAHGPDAIRQALANVPAHGLPALYDAGNIACEHGDLESAQLALAGSVHNILSRGGFPLVLGGGHEVAWGTWQGLRAHLDARNDDGRLLIINIDAHFDLRTSRPASSGTPFDQIANACAERGQPFDYVCLGVSRLSNTPALFSRAHALGVSYVEDVDMQERHLASRLAELAARIDATDHVYLTIDLDALPATVMPGVSAPAAYGVPLPVVEEIALLARRSGKLRAADLAEYNPQYDRDNLGARVAARLAWRLLG
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: USPB_ECO81
Sequence: MISTVALFWALCVVCIVNMARYFSSLRALLVVLRNCDPLLYQYVDGGGFFTSHGQPNKQVRLVWYIYAQRYRDHHDDEFIRRCERVRRQFILTSALCGLVVVSLIALMIWH
What are the official names of this protein?
Universal stress protein B.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YQ56_SCHPO
Sequence: MHRLFGRKPPTQPTASLTDAIDSLDKRSDSVEVKIAKLDAQLSVFQQKIANTRPGPGQTALKQRAMNVLRQKKIYESQLQQLQQQSFNMEQAAMTTESLKNTMATVQTMQETARQLKSQSKNVSIEKIEKLQDEIQDYMDAAGELNEVLGQNMTDINVDEEELDAELEALQQESSWLGDQSTAEKPSYLMPSNELPNFVDEEVAEPSTAQ
What are the official names of this protein?
Uncharacterized protein C162.06c.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
Protein: UBP36_DROME
Sequence: MPVSMAVCETANVVNAALRESLGGNSSAGSSTDQAKSGEDTNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFSGKNNTGKLVGANGHDNNGARKQAEHPNNQSHHINHHNHQHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMTKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGNKLTKQISFKSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFFELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPAGGANGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGKFQDTAKPPLVGAHAKGEATSAPTANGNKSSSPSSNSSSNHKSINQQQYLPISSDDEDIEDEMKPRPTTAQLPSMPNMTENHTEPKAKSPVKIQVKTPVKTPLKSLVPYESASEEEEAPLPNPRKRPSGEDSSESDQESGQTNGHSKTNGSHTNGSASSSVHVNNSKQKTDAIDEIFKSLKKSADSDEDDDEEEPSIQLTNGWHPQKQSQSQSKAPPSPKTPPSPAVIKSKTGIWKVTRNDEVDAIEDDVDVVVVEGSPVKIPTPNKNHRNPFSSSKPSTDSPATPGAKRQKLLNGSALKSHQQPRVGNGYQSNATSNGSTINELLKQSYRGYGSPVLSWNGKPAELEKELLVDAREQRQRDIDDDEENEMDRGRQRKVKSGSAKGNNASNSTPGYNPFQEYEGQKRWNKNGGGGGFPRFYNQNYRQNFQQRNKFKFNRFGGPGSAKFQQQRALQRHLSAGGGFSRRQPSAQQQQQT
What is the function of this protein?
Hydrolase that deubiquitinates polyubiquitinated target proteins including imd (PubMed:19837371, PubMed:19039105).  Required for preventing the constitutive activation of the imd/NF-kappa-B (Imd) signaling cascade under unchalleneged conditions (PubMed:19837371, PubMed:25027767).  Deubiquitinates imd linked 'Lys-63' chains which leads its proteasomal degradation and consequently down-regulation of the Imd signaling cascade (PubMed:19837371).  Removal of the activating 'Lys-63'-linked chains is likely to enable their replacement with 'Lys-48'-linked chains which act as 'tags' the for proteosomal degradation of imd (PubMed:19837371).  Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells (PubMed:19039105).  May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4me3) (PubMed:19039105).  Controls selective autophagy activation by ubiquitinated proteins (PubMed:22622177).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 36, Deubiquitinating enzyme 36, Protein scrawny, Ubiquitin thioesterase 36, Ubiquitin-specific-processing protease 36.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cytoplasm.
Protein: PRMA_JANMA
Sequence: MSWTEIVIEVARTHAEALSDALMEAGALSVSVEDADFGTDAEQPLFGEPGMEPTEAAWEHSRVVALTPVEADQAAIVAEAAQAVGLAATDVAFTLRAVEEQDWVRLTQSQFEPIHIGKNIWVVPSWHDAPDPQALVLELDPGLAFGTGSHPTTRLCMEWLEAHPPVGLSVLDYGCGSGILAMVAAKLGSTDVIGIDIDPQAIKSALFNTERNHCEVAYYLPDEFASSGHAHTFDVVVANILANPLKVMAPMLSGRVKPGGKLILSGVLATQVEEVSAAYAPFIKLSVWAEHEGWVALAGQLPPGPESGQA
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKBB_ECOLI
Sequence: MTTPTFDTIEAQASYGIGLQVGQQLSESGLEGLLPEALVAGIADALEGKHPAVPVDVVHRALREIHERADAVRRQRFQAMAAEGVKYLEENAKKEGVNSTESGLQFRVINQGEGAIPARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNGVIPGWIEALTLMPVGSKWELTIPQELAYGERGAGASIPPFSTLVFEVELLEIL
What is the function of this protein?
PPIases accelerate the folding of proteins (Probable).  Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:8703024).  Displays a preference for substrates with a lysyl residue in the P1 position (PubMed:8703024).
What are the official names of this protein?
FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase, FKBP22, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm. Periplasm.
Protein: DED1_PICGU
Sequence: MSDITHKMNELSVGDGANRASGAAAGGETPSGSSGRSQYVPPHLRNRPNGGSTPSRRGDFGSRSNGFGSGRRGDFNSSGFQFGSGRRGNSGFGGRGGFGGGSGRYNSPKPGVGQWVDGKHEPAAPNERLEKELFGVAEDPSVQSSGINFDNYDDIPVEATGDGVPEPISAFTAPPLDPLIVENIKLSRFTKPTPVQKYSVPIVASGRDLMACAQTGSGKTGGFLFPVLSESYMNGPDAVPESQGAFSSHKVHPTALVMAPTRELVSQIFEEAKKFSYRSWVRPCVVYGGADIGTQIRNLDRGCDLLVATPGRLKDLLERGRVSLSNIKYLVLDEADRMLDMGFEPQIRHIVQECDMPGVESRQTLMFSATFPRDIQMLARDFLKDYIFLSVGRVGSTSENITQKVLYVEDDEKKSVLLDLLSANDNGLTIIFTETKRMADNLADFLYDQGFPATAIHGDRSQYEREKALAAFKSGTAPILVATAVAARGLDIPNVSHVVNYDLPGDIDDYVHRIGRTGRAGNVGIATAFFNRNNRNVVKGMIELLSEANQEVPDFLQKISREGSYGSKGGFGSMRGGAGRGVLGGGSRGGSRDFRRSGGGFGSSGSSGSNWGSSSSGNGGYRSSSNYGNPSSGNSWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DED1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSA_AERS4
Sequence: MSKSDQLFEQARQTIPGGVNSPVRAFNGVGGTPRFIDHADGAYLYDVDGQAYVDYIGSWGPMLLGHNHPAIKAAVIKAVEKGLSYGAPTEIEVLMAEKVRQIVPSMEQVRMVNSGTEATMSAIRLARGYTGRDKIVKFEGCYHGHADSLLVKAGSGALTLGQPNSPGVPADFAKHTLTCVFNDLDSVREAFTQYGCDIACIIVEPVAGNMNCIPPVPGFLEGLRTICDEFGALLILDEVMTGFRVSLRGAQGYYNIDPDLTTLGKIIGAGMPVGAFGGKKKVMQHIAPTGPVYQAGTLSGNPVAMAAGLTMLDLLLEPGLYEQLNAKTARVAEGLKAAAAKHGIPLAINYVGGMFGFFFTDEPEITRYEQVTRCDMERFKRFYHLMLEEGVYLAPSAYEAGFLSLAHGDKEIEHTLAAAERSFAKLAG
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_SHEHH
Sequence: MQSDIEISRQHTCLPITEIAKDLGLNPDEFSPCGVNKAKVSQSVARRLADKKNAKLVIVTAVTPTPFGEGKTVTTIGLTQAMNLNGIKTCACIRQPSMGPVFGTKGGAAGGGYAQVVPMEELNLHLTGDIHAVSSAHNLAAAAIDARLFHEHRLGAEVFAQESGLSALNIDSENILWRRVVDHNERSLRQIKVGYGKVNGPVHESGFDITAASELMAILALSQDLKDLRQRIGRLVLALNTQGEPITAEELGVAGAMTVIMADAIEPTLMQTLSGDPCFIHAGPFANIAHGNSSIIADTIAAKLADVVITEAGFGSDMGFEKFSNIKVRESGYAPSASVVVVTLKALKANSGIESDKDINQPDMERLQAGFANLEWHINNVSQYGVPVVVAINRFPTDTDEELEWLKQAVEQTKAFGSEISEAFGKGAEGATKLADMVYHATQTPSDFKLLYQSDTSLEAKLMTLAEVGYGASSVTLSDKAKSQLHWLTKHNYGQLPICVAKTPMSISHDPSIKGIPTEFELPITELRLNAGAGFVTALVGQVMTMPGLGIKPGYLNVDINDDGEIIGLA
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: ESP3_ARATH
Sequence: MASNDLKTWVSDKLMMLLGYSQAAVVNYLIAMAKKTKSPTELVGELVDYGFSSSGDTRSFAEEIFARVPRKTAGVNLYQKHEAEAAMLVRKQKTYALLDADDDEDEVVVEKKSSVSESRKSDKGKKRFRKKSGQSDESDGEVAVREDSRHVRRKVSEEDDGSESEEERVRDQKEREELEQHLKDRDTARTRKLTEQTLSKKEKEEAVRRANALEKDDLYSLRKVSRQEYLKKREQKKLDELRDEIEDEQYLFGGEKLTETELREFRYKKELYDLVKKRTQDEDNVEEYRIPDAYDQEGGVDQEKRFSVAVQRYRDLDSTEKMNPFAEQEAWEDHQIGKATLKFGAKNKQASDDYQFVFEDQINFIKESVMAGENYEDAMDAKQKSQDLAEKTALEELQEVRRSLPIYTYRDQLLKAVEEHQVLVIVGDTGSGKTTQIPQYLHEAGYTKRGKVGCTQPRRVAAMSVAARVAQEMGVKLGHEVGYSIRFEDCTSDKTVLKYMTDGMLLRELLGEPDLASYSVVIVDEAHERTLSTDILFGLVKDIARFRPDLKLLISSATMDAEKFSDYFDTAPIFSFPGRRYPVEINYTSAPEADYMDAAIVTILTIHVREPLGDILVFFTGQEEIETAEEILKHRIRGLGTKIRELIICPIYANLPSELQAKIFEPTPEGARKVVLATNIAETSLTIDGIKYVVDPGFSKMKSYNPRTGMESLLITPISKASATQRAGRAGRTSPGKCYRLYTAFNYNNDLEENTVPEVQRTNLASVVLALKSLGIHDLINFDFMDPPPAEALVKSLELLFALGALNKLGELTKAGRRMAEFPLDPMLSKMIVVSDKYKCSDEIISIAAMLSIGGSIFYRPKDKQVHADNARMNFHTGNVGDHIALLKVYSSWKETNFSTQWCYENYIQVRSMKRARDIRDQLEGLLERVEIDISSNLNELDSVRKSIVAGFFPHTAKLQKNGSYRTVKHPQTVHIHPNSGLSQVLPRWVVYHELVLTSKEYMRQVTELKPEWLIELAPHYYQLKDVEDAASKKMPKGAGKAAM
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1, DEAH RNA helicase homolog PRP2, Protein EMBRYO DEFECTIVE 2733, Protein ENHANCED SILENCING PHENOTYPE 3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. PRP2 sub-subfamily.
Protein: LPXI_CAUVC
Sequence: MRKLGLIAGGGALPVELASHCEAAGRAFAVMRLRSFADPSLDRYPGADVGIGEFGKIFKALRAEGCDVVCFAGNVSRPDFSALMPDARGLKVLPSLIVAARKGDDALLRRVLDEFEKEGFEIEGAHEVMGEMTLPRGRLGKVSPAPEHMADIDKALDVAREIGRLDIGQGAVVCEGLVLAVEAQEGTDAMLRRVADLPEAIRGRAERRLGVLAKAPKPIQETRVDLPTIGVATIHRAARAGLAGIVGEAGRLLVVDREAVIAAADDLGLFVLGVDPQERP
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to form 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the beta-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.  Can functionally complement lpxH deficiency in E. coli.  Cannot use CDP-diacylglycerol as substrate.
What are the official names of this protein?
UDP-2,3-diacylglucosamine pyrophosphatase LpxI, UDP-2,3-diacylglucosamine hydrolase LpxI.
What is the protein family that this protein belongs to?
Belongs to the LpxI family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FPG_BACAN
Sequence: MPELPEVENVRRTLENLVTGKTIEDVIVTYPKIVKRPDDAEIFKEMLKGETIENIKRRGKFLLLYVTNYVIVSHLRMEGKFLLHQEDEPIDKHTHVRFLFTDGTELHYKDVRKFGTMHLFKKGEEMNQMPLADLGPEPFDAELTPQYLHERLQKTNRKIKVVLLDQRLLVGLGNIYVDEVLFRSQIHPEREASSLTAEEIERIYEATVTTLGEAVKRGGSTIRTYINSQGQIGSFQELLNVYGKKGEPCVTCGTILEKTVVGGRGTHYCPICQPRI
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: GIT7_SCHPO
Sequence: MGVDLSDINDSLFKLSDKLSNDLAKQRNLCIVKEPSFSIEEHIKCFTTCINTYKPFSCLKHANWALLLAKKKSDTGLIGYCQSLRGLAYYLLEQYQSSAICFGFALKHLKKEDLTKWQVQLDSMLTIVHEQQNQDTSSLIPDECPNIPELEAAKIEGDEEFLNMSLKAPEGQIEKNEEKLSNRIRYDWSQTSFSLNIDIYAKKVKDEDVSLLMEKNTLKIEIKLEDGSIFSLVLDPLYEEIVPEKSSFKLFSSKVEITLIKKVSEIKWEALVKSPANNSVNVYAKDSNHSSASGNTKNKAKDWDSLAKLADLEEDEPTGEAALANLFQNLYKNADDDTRRAMMKSYTESNGTALSTNWKDVKSKTFETKPPQGMEPKKF
What is the function of this protein?
Involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes.
What are the official names of this protein?
Glucose-insensitive transcription protein 7.
Protein: MOAA_STAAC
Sequence: MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: LGT_BURCJ
Sequence: MIIHPNFDPVAIHLGPLAVRWYGLMYLVGFIAAIVVGRIRLKLPYVAAQGWTAKDIDDMMFYGVLGTVLGGRLGYVLFYKADFYFSHPLDVFKVWEGGMSFHGGFLGVTLAMMLFAWQRKRHWLQVTDFVAPMVPTGLAAGRLGNFINGELWGRVTDPTAPWAMLFPGAMRDDAAWLPKHPALVEKWHLADVFMQYQMLPRHPSQLYEIALEGIALFFVLFLFARKPRPMGAISALFLIGYGLARFTVEFAREPDDFLGLLALGLSMGQWLSLPMIVAGVAMMVWAYRRRAANANAAA
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UL24_GAHVM
Sequence: MSSEMPLPTTIVAPTCSMGEKNVLKRYRRQVSSTRNFKRHVNTNVLRKRRLAAGVRCHDRFYKRLYAEAMCLGSQVYDWPGRSFAKIFGKVMVLDVFKQLTDFRLVFEVNLERRRPDCICMFKLPRDLWEVGCDGVCVILELKTCKFSRNLKTRSKHEQRLTGIKQLLDSKSLIGQIAPQGSDCIVICPMLVFVARRKLSVLHVMCLKKRHIVTDFHRLCSILATASDYKARITDTHKILKRHNTNTIHIQRRSGKASANVTDLRNHIACNKTATLSFSNNQERTGGTAMRNMANIIARLVQRP
What is the function of this protein?
May play a role in the dispersal of host nucleolin from the nucleolus throughout the nucleus leading to a decrease in ribosome biogenesis.
What are the official names of this protein?
Protein UL24 homolog.
What is the protein family that this protein belongs to?
Belongs to the HHV-1 UL24 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host Golgi apparatus.
Protein: RSMJ_SHEPW
Sequence: MVMGVIIIGSIFIKQSLIVTSIFFNQQYPTLESVAERWGLTYSKDAEFELVFENNILSLIKRDEPKLKGISVDFVSGAVAHRRKFGGGRGQSIAKAVGLKQGVTPTVVDGTAGLGRDAFVLASLGCKVIMVERHPVVAALLEDGLRRAYEDSEIGEWMNARMSLFHGSSIDTLADAANAAGTEIDVVYLDPMYPHREKSALVKKEMRVFQSLVGADLDADGLLKPAMELASKRVVVKRPDYAEDLDGVKPSTVIATKKNRFDVYVKAAMIS
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCAM2_MOUSE
Sequence: MSAFDTNPFADPVDVNPFQDPSVTQLTNAPQSGLAEFNPFSETNAATTVPATQAPGPSQPAVLQPSVEPAQPTPQAVAAAAQAGLLRQQEELDRKAAELERKERELQNTAANLHVRDNNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFTSDAANGTAFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSFFVFFFVFFCQIGIYFIQLIGLPNLGTSGWLAALSTMKNGPLAVTIIMMVVAGFFTLCAGLSLFLLQRVHAFYRRTGASFQQAQEEFSQGIFSSRTFRGAASSAARGAFQGN
What is the function of this protein?
Functions in post-Golgi recycling pathways.  Acts as a recycling carrier to the cell surface (By similarity).
What are the official names of this protein?
Secretory carrier-associated membrane protein 2, Secretory carrier membrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the SCAMP family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Protein: FMT_LACLM
Sequence: MTKTKIIFMGTPQFAATVLKGLIDSNKYEILAVVTQPDRKVGRKQELRMTPVKELALTVNLPVLQPEKLSGSVEMTQIMTLLESGEVGIVTAAFGQFLPGKLLVVARFAVNTHASLLPKYRGGAPIHYAIMNGEKEAGVTIMEMIRKMDAGDMIAQNSTPILEEDNVGTMFEKLAFVGRDLLLETLPKYLEGQLKAQAQNEDEVTFSPNISPEEEKIDWNKSAREIFNKVRGMNPFPVAHTLWNGERFKIYESKVADEIVNNSDNPLQAGQIVEKTKKSLKVATGNGILELLTVQPAGKPKMDIVSFLNGLGQKMQVGDKLGD
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RF1_FLAJ1
Sequence: MLDRLQYVKQRFDEISDLIIQPDVISDQKRYKSLNQEYKGIKALVEKREEYIIVLANIDEANEIIADGSDAEMVEMAKMQLDEAKDRLPELEEEIKFMLIPKDPEDAKNVMVEIRAGTGGDEASIFAGDLFRMYTKYCETMGWRTSVVDMNEGTSGGFKEVIFEVTGEDVYGTLKFEAGVHRVQRVPQTETQGRVHTSAATVMVLPEAEEFDVQVDMNDVRVDFFCSSGPGGQSVNTTKSAVRLTHIPTGLVAQCQDEKSQHKNKDKALMVLRSRLYEMELAKKQEEDAKKRSSQVSSGDRSAKIRTYNYAQGRVTDHRVGLTLYDLGNIMNGDIQKIVSELQLVNNMEKLKEASEVY
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.