PharMolix/UniProtQA huggingface dataset:
Protein: WT1_XENTR
Sequence: MGSDVRDMNALLPPVSTLSGNSSCSMPVSSSGQWAPVLDFPPGAPYSSLPPHSFIKQEPTWNPDPHEDQCLSAFTVHFSGQFTGTAGACRYGAFGAPTPSQATTGQARMFPNSPYLSNCLDNQQGMRNQGYSAVAFDGTPSYGHTPSHHTAQFTNHSFKHEDPMGQQTSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYNSDNLYQMTSQLECMTWNQMNLGSSLKSHGTSYENDSHSTPMLYSCGGQYRIHTHGVFRGIQDVRRVPGVTPAIVRSSTEANEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGIKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
What is the function of this protein?
Transcription factor required for development of the vascular component of the pronephric kidney, the glomus; may repress tubule-specific gene expression in the portion of the pronephros fated to form the glomus (By similarity).  Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity).  Inhibits Wnt-signaling during embryonic development (By similarity).
What are the official names of this protein?
Wilms tumor protein homolog.
What is the protein family that this protein belongs to?
Belongs to the EGR C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus speckle. Note=Shuttles between nucleus and cytoplasm.
Protein: DHOM_SCHPO
Sequence: MSASRTNVNVAIVGTGNIGGELLNQIKGFNENASTNGTTSFNVVAISSMEGHYVSKDYQPINLSEWKNLTSQNQGAYSLDALVDFLAKSPLPAILVDNTASEAIAQSYPKFLSKKINIATPNKKAFSASNDVYQNIIKASKESGALLMHEASVGAGLPIISTLKELIATGDEIIKIEGIFSGTLSYIFNVWSPNGKKGTASFSDIVKIAKQNGYTEPDPRDDLNGMDVARKVTILSRIAGVHVESASSFPVKSLIPEPLKSAVNAEEFLAGLPNFDSEFASMREEAEKEGKVVRFVGEADVANKTTLVKLEKYDASHPFANLQSSDNIISFTTKRYHTRPLVVIGAGAGAAVTAAGVLGDMIKIMSQVRASDAPSA
What are the official names of this protein?
Probable homoserine dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the homoserine dehydrogenase family.
Protein: DNLJ_DESVH
Sequence: MTEVKTGRVVDDAPVNDAPENNAAEATSPARHDAIPEEARQRAAQLRADLERHNRLYYELDTPEISDAEYDALYRELVGLETRWPALRDEASPTQRVGGEVLEGLEKQAHTLRMYSLDNAFSRDEWGAFIQRMYNALPDAPSAFWCDPKMDGLALEVIYENGVFTSALTRGNGEVGEVVTAAMRTVRNLPLALRGDDVPRRIEVRGEVVIAKADFEQLNARQSAAGGKLFANPRNAAAGSVRQLDTTVTAGRPLQFLAYGVGQVVLEGGTAPWTTHSGLMARLREWGFDTPPEGRLCASPDEVWAYYEALGARRESLAIEIDGVVAKLDDTEAQEALGFTARAPRWALALKFPAMQARTRLDDIRVQVGRTGVLTPVAILEPVRVGGVEVSRATLHNEDEIRAKGLMLGDMVLVQRAGDVIPEVVRPLVEERTGDERPFVFPENCPECDSPVVRPQGEVAHRCVNVMCPAVRRQSIIHFVSKAGLDVRGVGERWVQQLVDGGHVTSPVGLFLLTKLDLMRFERMGPTSAANFVTALDAARTGATLVRLICALGIRHVGEQTARTLAANFTDLDALREADAETLQQLPDIGPEVAGSIRSFFANEGNLELLERLRAIGLWPKRQDAPPASEGADAIVLPLQGLKVLFTGSLTRVGRTEAEDMARAAGANIASSVTKSLDLLVVGGKPGSKLEKARKLGIRVMEEADFFAMLASGVASVDASEAVAEETPPSQEAAGAEDAPSQGAAHVRTASDETGSASGDDSRGAAAENDPARPARGGAMSTAEGEDVPRGRAEQLKLF
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PLBL1_MOUSE
Sequence: MCHRSPGRSLRPPSPLLLLLPLLLQPPWAAGAASQSDPTGVHCATAYWSPESKKVEIKTVLDKNGDAYGYYNDSIKTTGWGILEIRAGYGSQVLSNEIIMFLAGYLEGYLTALHMYDHFTNLYPQLIKNPSIVKKVQDFMEKQEMWTRQNIKAQKDDPFWRHTGYVVTQLDGLYLGAQKRASEEKIKPMTMFQIQFLNAVGDLLDLIPSLSPTKSSSMMKFKIWEMGHCSALIKVLPGFENIYFAHSSWYTYAAMLRIYKHWDFNIKDKYTLSKRLSFSSYPGFLESLDDFYILSSGLILLQTTNSVYNKTLLKQVVPKTLLAWQRVRVANMMAEGGKEWAQIFSKHNSGTYNNQYMVLDLKKVTINRSLDKGTLYIVEQIPTYVEYSDQTNVLRKGYWASYNIPFHKTIYNWSGYPLLVHKLGLDYSYDLAPRAKIFRRDQGNVTDMASMKYIMRYNNYKEDPYSKGDPCSTICCREDLNGASPSPGGCYDTKVADIFLASQYKAYAISGPTVQDGLPPFNWNRFNETLHRGMPEVFDFNFVTMKPILS
What is the function of this protein?
Exhibits weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.  However, in view of the small size of the putative binding pocket, it has been proposed that it may act rather as an amidase or a peptidase (By similarity).
What are the official names of this protein?
Phospholipase B-like 1, LAMA-like protein 1, Lamina ancestor homolog 1, Phospholipase B domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the phospholipase B-like family.
What are the subcellular locations of this protein?
Lysosome.
Protein: TATAD_BACSU
Sequence: MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSATKSLVSGDEKEEKSAELTAVKQDKNAG
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.  Required for PhoD secretion.  The cytosolic fraction of TatAd binds the precursor of PhoD.
What are the official names of this protein?
Sec-independent protein translocase protein TatAd.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Cytoplasm, cytosol. Note=At the onset of phosphate starvation, substantial amounts of TatAd are present in the cytosol. Upon ongoing starvation, the amount of TatAd in the cytosol decreases.
Protein: NTF2_DICDI
Sequence: MQSVDPQVVGVGKQFVEHYYGIFDSNRAGLTQIYQQQTTLTWEGKFLSGADAIVKHIVELPFQQTNRKINSIDCQQTYQPGIMITVTGTLIIDGEAKNQLKFVQVFNLASNNGSFLLINDFFRLVLD
What is the function of this protein?
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport.  Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport.  Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
What are the official names of this protein?
Nuclear transport factor 2, NTF-2.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.
Protein: RL18_CHLCH
Sequence: MSQVDKAARRQKIKDRSRVSVQGTASKPRLCIYRSLAEMYAQLIDDVNGKTLVTASTMTKNNKAFEGTKSDASRIVGQQIAEKALAAGITNVVFDRNGFRYHGRVKALADGAREAGLIF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: DXS1_STRCO
Sequence: MTILENIRGPRDLKALSEAELGELSDEIRDFLVHAVARTGGHLGPNLGVVELTVALHRVFESPDDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREESAHDVIENSHASTVLGWADGLAKARQVQGERSHVVAVIGDGALTGGMAWEALNNIAAARDRPLIIVVNDNERSYAPTIGGLANHLATLRTTDGYERALAWGKDVLQRTPVVGHTVYEALHGAKKGFKDAFAPQGLFEDLGLKYLGPIDGHDIGAVESALRRAKRFHGPVLVHCLTEKGRGYEPALRDEEDHFHTVGVMDPLTCEPLGPAGGPSWTSVFGEEIVRIGEERADVVAITAAMLHPVGLAPFAERFPDRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQLLMDVALHRCGVTFVLDRAGVTGVDGASHNGMWDMSVLQVVPGLRIAAPRDADQLRTQLREAVAVDDAPTLLRFPKESVGPAVPAVDRIGGLDVLHTADRSEVLLVAVGVMAPVCLGAAELLEARGIGCTVVDPRWVKPVDPALAPLAARHRLVAVVEDNSRAAGVGSAVALALGDAEVDVPVRRFGIPEQFLAHAKRAEVLADIGLTPVDVAGRIAASLALAEPAGDRAGGPAVEQPGDGRMSGDGRIVMPAQGEN
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase 1, 1-deoxyxylulose-5-phosphate synthase 1, DXP synthase 1, DXPS 1.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: PST2_PETHY
Sequence: MASITMMSSFLGGSTVAPAKVPSANRRGVVMVKAMHEGENNVVISKNEESKNSGRRELFFAMAAAAACSVAKTAMADEEPKRGTPEAKKKYSSVCVTNPTARICRY
What is the function of this protein?
May be a component of the oxygen-evolving complex.
What are the official names of this protein?
Photosystem II 5 kDa protein, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: RNPH_DESAP
Sequence: MIRVDGRAPAQMRPVYITRHYNKYAEGSALIEVGDTRVICTASIDNRVPTFLKGAGKGWVTAEFGMLPRATGVRGIRESVKGHPGGRSLEIQRLIGRSLRAVVDLPALGERTVILDCDVIQADGGTRTAAITGGFVALVDAMQTLVTEGVTPRLPVLDYVAATSVGLFEGEAVLDLCFAEDSAAEVDFNVVMTGTGRFVEVQGTGEGTTFERADVDRLLDLAVVGIRSLVEQQRAVLGSLAEEIGKRRGNQNGAAGTGDQK
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: ENGB_GEMAT
Sequence: MVIRHLEYLGPMATIDGWRPEITLPEIAFVGRSNVGKSSLLNKLMRRKSFARVSTTPGRTREIHFFDVNHQFVLADLPGYGYARISKERKAEWRPLIEGYLGTSPRLQGVVQLLDVRHDPTNDDYVMMDFLADVGVPTIVAITKIDKLKPAQARARVEELSKRLGLDADQVVPFSAHTGAGRDELASALMQLLAMPDWRTTEEE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: RS8_PROMA
Sequence: MANHDPISDMLTRIRNASQKRHENTRIPASRMSRSIAKVLQNEGFISQVSEEGEGVKTQLVLELKYSGKHRHPTIRSMKRVSKPGLRIYKNNRGLPKVLGGLGVAIISTSKGVMSDRDARKQGVGGEVLCYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SRY_GORGO
Sequence: MQSYASAMLSVFNSDDYSPAVQQTIPAHRRSSSFLCTESCNSKYQCETGENSKGSVQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL
What is the function of this protein?
Transcriptional regulator that controls a genetic switch in male development.  It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.  Involved in different aspects of gene regulation including promoter activation or repression.  Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.  SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending.  Also involved in pre-mRNA splicing (By similarity).  In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
What are the official names of this protein?
Sex-determining region Y protein, Testis-determining factor.
What is the protein family that this protein belongs to?
Belongs to the SRY family.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Nucleus.
Protein: YGXB_BACSU
Sequence: MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQLNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPSRYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLILLLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVFLPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLASIGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSMLNTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLSLSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAGELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFALAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM
What are the official names of this protein?
Uncharacterized protein YgxB, ORF1.
Protein: E1310_ARATH
Sequence: MASSSLQSLFSLFCLALFSLPLIVSSIGINYGQVANNLPPPKNVIPLLKSVGATKVKLYDADPQALRAFAGSGFELTVALGNEYLAQMSDPIKAQGWVKENVQAYLPNTKIVAIVVGNEVLTSNQSALTAALFPAMQSIHGALVDCGLNKQIFVTTAHSLAILDVSYPPSATSFRRDLLGSLTPILDFHVKTGSPILINAYPFFAYEENPKHVSLDFVLFQPNQGFTDPGSNFHYDNMLFAQVDAVYHALDAVGISYKKVPIVVSETGWPSNGDPQEVGATCDNARKYNGNLIKMMMSKKMRTPIRPECDLTIFVFALFNENMKPGPTSERNYGLFNPDGTPVYSLGIKTSSTHSSGSGSSNSTGGSSSGGGGNTGGSSSGGGIYQPVTGNPSPDYMSISSAGGKGRFVECVLFFFLLCIIKLRL
What is the function of this protein?
Plasmodesmal-associated membrane beta-1,3-glucanase involved in plasmodesmal callose degradation and functions in the gating of plasmodesmata.
What are the official names of this protein?
Glucan endo-1,3-beta-glucosidase 10, (1->3)-beta-glucan endohydrolase 10, (1->3)-beta-glucanase 10, Beta-1,3-endoglucanase 10, Beta-1,3-glucanase 10, Putative plasmodesmal associated protein, AtBG_ppap.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Cell junction, plasmodesma.
Protein: RL22_BEII9
Sequence: MSKEKTPRSLGDNEAKAVARMLRVSPQKLNLVAQLIRGKKVDKALADLEFSRKRIAYDVKKTLESAIANAENNHSLDVDDLIVAEAFVGKAMVMKRFSPRARGRSGRIEKPFAHLTIVVREVTAVAAGA
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: TRM5_YEAST
Sequence: MKIALPVFQKFNRLISSCKMSGVFPYNPPVNRQMRELDRSFFITKIPMCAVKFPEPKNISVFSKNFKNCILRVPRIPHVVKLNSSKPKDELTSVQNKKLKTADGNNTPVTKGVLLHESIHSVEDAYGKLPEDALAFLKENSAEIVPHEYVLDYDFWKAEEILRAVLPEQFLEEVPTGFTITGHIAHLNLRTEFKPFDSLIGQVILDKNNKIECVVDKVSSIATQFRTFPMKVIAGKSDSLVVEQKESNCTFKFDFSKVYWNSRLHTEHERLVKQYFQPGQVVCDVFAGVGPFAVPAGKKDVIVLANDLNPESYKYLKENIALNKVAKTVKSFNMDGADFIRQSPQLLQQWIQDEEGGKITIPLPLKKRHRSQQHNDQQPPQPRTKELIIPSHISHYVMNLPDSAISFLGNFRGIFAAHTKGATDTIQMPWVHVHCFEKYPPGDQVTEDELHARVHARIIAALKVTADDLPLNAVSLHLVRKVAPTKPMYCASFQLPANV
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.  Postspliced cytoplasmic tRNAs are imported into the nucleus, where this first step seems to take place, after which they are reexported to the cytoplasm, where the yW sythesis is completed by cytoplasmic enzymes.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: UXAB_CROS8
Sequence: MKTLNRRDFPGALWPERIIQFGEGNFLRAFIDWQVDLLNEHTDLNAGVVVVRPIASDFPPSLSTQDGLYTTIIRGLNEKGEAVSESRLIRSVNREISVYAQYDEFLKLAHNPDIRFVFSNTTEAGISYHAGDQFDDAPAVSYPAKLTRLLFERFSHFDGAQDKGWVIIPCELIDYNGEALRELVLRYAHEWALPAAFTTWLESANSFCSTLVDRIVTGYPRDEVAQLEESLGYHDAFLDTAEHFYLFVIQGPQWLARELRLDKLPLNVLIVDDIKPYKARKVAILNGAHTALVPVAFLAGLNTVGEAMNDAQICAFVERAIHDEIIPVLDLPRNELESFADAVVSRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQAQMGTLPPRLTFALAALIAFYRGERNGEGYPLQDDAHWLARFEQLWTQRGDNTITLRELVDAVLSDCEHWEQDLTAVPGLAAQVTRDLDAILNQGMRHAVAPLC
What are the official names of this protein?
Altronate oxidoreductase, Tagaturonate dehydrogenase, Tagaturonate reductase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family. UxaB subfamily.
Protein: Y726_MAGMM
Sequence: MKFATLAGKFLIAVPSLADPFFERTVLYLCAHNEDGALGLVINQPLDTTMSQMAGYLELDWQRPGVDRVYMGGPVSPEQGFVLFEQALDLPGIMMLPDDLYMGTNPDIIRLMGRAGAQERFLFALGYAGWEAGQLEHELQENSWLVCDAQRSILFDMGYAQRWEAAIRSMGIDPALLVDASHGFAN
What are the official names of this protein?
UPF0301 protein Mmc1_0726.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: TNFL6_HUMAN
Sequence: MQQPFNYPYPQIYWVDSSASSPWAPPGTVLPCPTSVPRRPGQRRPPPPPPPPPLPPPPPPPPLPPLPLPPLKKRGNHSTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGKSNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVNFEESQTFFGLYKL
What is the function of this protein?
Cytoplasmic form induces gene transcription inhibition.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115). SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted. Note=May be released into the extracellular fluid by cleavage from the cell surface. SUBCELLULAR LOCATION: [FasL intracellular domain]: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.
Protein: NTCP7_HUMAN
Sequence: MRLLERMRKDWFMVGIVLAIAGAKLEPSIGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSSVPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDKFSLVLILFIIFSIQLSFMLLTFIFSTRNNSGFTPADTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLLIYHPAQILLGSVLVPTIKSWMVSRQKGVKLTRPTV
What is the function of this protein?
Involved in teeth and skeletal development.  Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix.  Required for extracellular matrix mineralization (PubMed:30082715, PubMed:29878199).  Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616).  Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).
What are the official names of this protein?
Sodium/bile acid cotransporter 7, Na(+)/bile acid cotransporter 7, Solute carrier family 10 member 7.
What is the protein family that this protein belongs to?
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane.
Protein: UBIA_SALA4
Sequence: MEWSLTQSKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGMPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTVNRPLPSGAVTEKEARNLFVVLVLLAFLLVLTLNAMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESLPLSCWLMFLANILWAVAYDTQYAMVDRDDDIKIGIKSTAILFGRYDTLIIGILQLGVMALMALIGWLNGLGWGYYWAVLVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ERP2_YEAST
Sequence: MIKSTIALPSFFIVLILALVNSVAASSSYAPVAISLPAFSKECLYYDMVTEDDSLAVGYQVLTGGNFEIDFDITAPDGSVITSEKQKKYSDFLLKSFGVGKYTFCFSNNYGTALKKVEITLEKEKTLTDEHEADVNNDDIIANNAVEEIDRNLNKITKTLNYLRAREWRNMSTVNSTESRLTWLSILIIIIIAVISIAQVLLIQFLFTGRQKNYV
What is the function of this protein?
Involved in vesicular protein trafficking.
What are the official names of this protein?
Protein ERP2.
What is the protein family that this protein belongs to?
Belongs to the EMP24/GP25L family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: LSM2_DICDI
Sequence: MLFFSFYKSLVGKEITVELKNDLSITGLLQSVDQFLNIKLKDIKVNEEDKYPYMISVKNCFIRGSVVRYVHLPAEDVDVETLQDHSRLEAREQKKQNKQHQEQTNQKSSNTTTTTTV
What is the function of this protein?
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).  The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
What are the official names of this protein?
Probable U6 snRNA-associated Sm-like protein LSm2.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LECF_ASPFU
Sequence: MSTPGAQQVLFRTGIAAVNLTNHLRVYFQDVYGSIRESLYEGSWANGTEKNVIGNAKLGSPVAATSKELKHIRVYTLTEGNTLQEFAYDSGTGWYNGGLGGAKFQVAPYSRIAAVFLAGTDALQLRIYAQKPDNTIQEYMWNGDGWKEGTNLGGALPGTGIGATSFRYTDYNGPSIRIWFQTDDLKLVQRAYDPHKGWYPDLVTIFDRAPPRTAIAATSFGAGNSSIYMRIYFVNSDNTIWQVCWDHGKGYHDKGTITPVIQGSEVAIISWGSFANNGPDLRLYFQNGTYISAVSEWVWNRAHGSQLGRSALPPA
What is the function of this protein?
Multispecific lectin that is able to recognize L-fucose in all possible linkages (PubMed:23695231, PubMed:27058347, PubMed:24340081, PubMed:25760594).  These could be found not only in decomposed plant matter in soil, which is the natural environment for A. fumigatus, but also in various epitopes on human tissues (PubMed:25760594).  Mediates binding of A. fumigatus conidia to airway mucin in a fucose dependent manner (PubMed:27058347).  Stimulates IL-8 production by human bronchial cells in a dose-dependent manner, contributing to the inflammatory response observed upon the exposure of a patient to A. fumigatus, and thus might be an important virulence factor involved in an early stage of A. fumigatus infection (PubMed:24340081).
What are the official names of this protein?
Fucose-specific lectin, Aspergillus fumigatus lectin, AFL.
What is the protein family that this protein belongs to?
Belongs to the fungal fucose-specific lectin family.
Protein: LEUC_YERPE
Sequence: MGTTSSQSKTLYQKLYDAHIVHEAPNETPLLYIDRHLVHEVTSPQAFDGLRAMGRPVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCAEFGVSLYDLNHPFQGIVHVIGPEQGMTLPGMTIVCGDSHTATHGAFGSLAFGIGTSEVEHVLATQTLKQGRAKTMRIEVNGTVGAGITAKDIVLAIIGKTGSAGGTGHVVEFCGSAIEALSMEGRMTLCNMAIEMGAKAGLVAPDDTTFAYLKGRQFAPTGEQWEQGVAYWRTLKSDADAQFDTIVTLDAADIAPQVTWGTNPGQVIAVNQIIPAPESFSDPVERASAEKALAYMDLRPGIKLTEVAIDKVFIGSCTNSRIEDLRAAAAIAQGRKVAKGVQAIVVPGSGPVKAQAEAEGLDKIFIAAGFEWRLPGCSMCLAMNNDRLEPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVSGHFADVRELSATTH
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.