PharMolix/UniProtQA huggingface dataset:
Protein: RBL_BOTST
Sequence: GVGFKAGVKDYRLTHYTPDYETKDTDILAAFRMTPQPGVPAAEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYEIEPVPGEENQFIAYVAYPPDLSEEGSVTNMFTSIVGNVFGFKALRALRLEDSRIPPAYSKTFMGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEALFKSQAETGEIKGHYSNATAGTCEEMLKRAVFARELGVPIVMHDYLTGGFTANTSLAFYCWDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSSGDHIHSGTVVGKLEGERDITLGFVDLLRDDYIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVAPEACVQARNEGRDLAREGNETIREAAKWSP
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PGM5_RAT
Sequence: MEGSPIPVLTVPTAPYEDQRPTGGGGLRRPTGLFEGQRNYLPNFIQSVLSSIDLRDRQGCTMVVGSDGRYFSRTATEIVVQMAAANGIGRLIIGQNGILSTPAVSCIIRKIKAAGGIILTASHCPGGPGGEFGVKFNVANGGPAPDVVSDKIYQISKTIEEYTICPDLRIDLSRLGRQEFDLENKFKPFRVEIVDPVDIYLNLLRTIFDFNAIKSLLTGPSQLKIRVDAMHGVMGPYVRKVLCDELGAPANSAINCVPLEDFGGQHPDPNLTYATTLLEAMKGGEYGFGAAFDADGDRYMILGQNGFFVSPSDSLAIIAANLSCIPYFRQMGVRGFGRSMPTSMALDRVAKSMKVPVYETPAGWRFFSNLMDSGRCSLCGEESFGTGSDHLREKDGLWAVLVWLSIIAARKQSVEEIVRDHWAKYGRHYYCRVLYEAKSPKATYYIMRDLEALVTDKSFIGQQFAVGSHIYSIAKTDSFEYVDPVDGTVTKKQGLRIIFSDASRLIFRLSSSSGVRATIRLYAESYERDPSGHDQEPQAVLSPLIAIALKISQIHERTGRRGPTVIT
What is the function of this protein?
Component of adherens-type cell-cell and cell-matrix junctions.  Has no phosphoglucomutase activity in vitro.
What are the official names of this protein?
Phosphoglucomutase-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma. Note=Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments.
Protein: PYRD_HALS3
Sequence: MYGLLKSALFGLPPETTHEITTSALRVAQRVGAHRAYAKQFTVTDPRLSVDAFGQTFPNPVGMAAGFDKNAEIPRALAGLGFGHIEVGAVTAERQPGNDRPRLFRLPDDNALVNRMGFNNEGADTVGARLDAEPLPDVPVGVNIGKSKTTPLADAPDDYTYTFSRVGDAVDYVVVNVSSPNTPGLRELQGRDQLAAILEALQDAGASPLLVKLSPDLHQDAVADAVELANDLGLDGIVATNTTTERPESLSHPHAGEQGGLSGAPIRERATEQVRFVAERTDQPVVGVGGVATAEDAYEKIRAGASVVQLYTALVYEGPWVAKRINEGLVSLLERDGFDSVEDAVGADL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SECP_VESVN
Sequence: MKNYSKNATHLITVLLFSFVVILLIIPSKCEAVSNDMQPLEARSADLIPEPRYIIDVPPRCPPGSKFIKNRCRVIVP
What is the function of this protein?
Nontoxic peptide.
What are the official names of this protein?
Secapin.
What is the protein family that this protein belongs to?
Belongs to the secapin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TMCA_ECOLI
Sequence: MAELTALHTLTAQMKREGIRRLLVLSGEEGWCFEHTLKLRDALPGDWLWISPRPDAENHCSPSALQTLLGREFRHAVFDARHGFDAAAFAALSGTLKAGSWLVLLLPVWEEWENQPDADSLRWSDCPDPIATPHFVQHLKRVLTADNEAILWRQNQPFSLAHFTPRTDWYPATGAPQPEQQQLLKQLMTMPPGVAAVTAARGRGKSALAGQLISRIAGRAIVTAPAKASTDVLAQFAGEKFRFIAPDALLASDEQADWLVVDEAAAIPAPLLHQLVSRFPRTLLTTTVQGYEGTGRGFLLKFCARFPHLHRFELQQPIRWAQGCPLEKMVSEALVFDDENFTHTPQGNIVISAFEQTLWQSDPETPLKVYQLLSGAHYRTSPLDLRRMMDAPGQHFLQAAGENEIAGALWLVDEGGLSQQLSQAVWAGFRRPRGNLVAQSLAAHGNNPLAATLRGRRVSRIAVHPARQREGTGRQLIAGALQYTQDLDYLSVSFGYTGELWRFWQRCGFVLVRMGNHREASSGCYTAMALLPMSDAGKQLAEREHYRLRRDAQALAQWNGETLPVDPLNDAVLSDDDWLELAGFAFAHRPLLTSLGCLLRLLQTSELALPALRGRLQKNASDAQLCTTLKLSGRKMLLVRQREEAAQALFALNDVRTERLRDRITQWQLFH
What is the function of this protein?
Also functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription.  Can specifically catalyze the 2-hydroxyisobutyrylation (Khib) of the DNA-binding protein H-NS.  Hydroxyisobutyrylation of H-NS decreases its DNA-binding activity, promotes the expression of acid-resistance genes and enhances bacterial survival under extreme acid stress.
What are the official names of this protein?
tRNA(Met) cytidine acetyltransferase TmcA, Lysine 2-hydroxyisobutyryltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK20_IPOPU
Sequence: MTRIKRGYIARRRRTKMHFFASSFRGAHSRLTRTMTQQEKRALVSAHRDRDRQKRDFRRLWITRINAVIRERGVSYSYSKFIHDLYKNQLLLNRKILAQIAISNRKCLDMISNEIV
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HNRPK_RAT
Sequence: METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQSKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLLIHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPDRVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFTMMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRGGSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAIDTWSPSEWQMAYEPQGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVKQYSGKFF
What is the function of this protein?
One of the major pre-mRNA-binding proteins.  Binds tenaciously to poly(C) sequences.  Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences.  Can also bind poly(C) single-stranded DNA.  Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression.  When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction.  As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53.  This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity).  As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein K, hnRNP K, dC stretch-binding protein, CSBP.
Protein: GMPR2_MOUSE
Sequence: MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVELTRSFSFRNSKQMYSGIPVIAANMDTVGTFEMARVLCKFSLFTAIHKHYSIHQWQEFASQNPDCLECLAASSGSGSADFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYSGGVAEYRASEGKIVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSNSQ
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable).  Plays a role in modulating cellular differentiation (By similarity).
What are the official names of this protein?
GMP reductase 2, GMPR 2, Guanosine 5'-monophosphate oxidoreductase 2, Guanosine monophosphate reductase 2.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Protein: Y1536_ACIBC
Sequence: MAGHSKWANIKHRKAKQDASRGKVFTKYIREIVTAAKLGGADPASNPRLRAVVEKALSVNMTRDTINRAIQRGVGGEDNDDLKEVTYEGYGVGGVAVLVETMTDNLNRTVPDVRHCFSKTNGNLGTAGSVAYLFTKRGEITFDDVSLEDKIMDVALEAGAEDIEVSEDEILVITSPETFGEVQDALAAAGLKSDNAEVVMSPSTKAEITDIDQAKQVMKLIDMLEDLDDVQNVYTNVEFSDEVLAQLDA
What are the official names of this protein?
Probable transcriptional regulatory protein ACICU_01536.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPG2_DICDI
Sequence: MNIRNSLILIISTILFFSIINGSLSLDPTCVGAPDGQVYLFSSWDFKGDRYVYNVSQGYLSLSDGFRGNVQSFISGADVCFVKWYPIEQYQITAGESHRNYAALTNFGQRMDAIIPGNCSNIVCSPK
What are the official names of this protein?
Spore germination protein 2, SPG2.
What is the protein family that this protein belongs to?
Belongs to the Dictyostelium gerABC family.
What are the subcellular locations of this protein?
Secreted.
Protein: RNC_ECO45
Sequence: MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSYVIANALYHRFPRVDEGDMSRMRATLVRGNTLAELAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQTVEKLILNWYQTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPTYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_CHICK
Sequence: MAPNIRKSHPLLKMINNSLIDLPAPSNISAWWNFGSLLAVCLMTQILTGLLLAMHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIFLHIGRGLYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGHTLVEWAWGGFSVDNPTLTRFFALHFLLPFAIAGITIIHLTFLHESGSNNPLGISSDSDKIPFHPYYSFKDILGLTLMLTPFLTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQTLFWLLVANLLILTWIGSQPVEHPFIIIGQMASLSYFTILLILFPTIGTLENKMLNY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ADE_PSYCK
Sequence: MIDLIKRLPKAELHLHIEGSLEPELMFRLAKKNQIEIPYKDIEDVRNAYNFTNLQTFLDIYYAGANVLITQDDFYDLTWEYILKCVEDNVIHTEIFFDPQTHTARGVTFETVITGIKRALADAKAQYGITSCIIMCFLRHLSQEEAFETLEQALPFKDDIIGVGLDSSELGNPPSKFIEVFKKAKEEGFKLVAHAGEEADFSYIYEALDLLDISRIDHGVQSIKSAELMQRLKDEQMPLTVCPNSNIELRVFNNYKEHNIKELLDYGLNITVNSDDPAYFKGYINQNFINISENLPLTEDDIITLVKNSFRSSFISDELKQQYLNRVDQAVG
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenine to hypoxanthine.  Plays an important role in the purine salvage pathway and in nitrogen catabolism.
What are the official names of this protein?
Adenine deaminase, ADE, Adenine aminohydrolase, AAH.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Protein: Y2443_SHEPA
Sequence: MICAVYKSLRKAESYLFVEKRNDFERVPEALMAMFGEPKLVMMLPIEKRDHLGFADIKKVRSELKEKGFYLQLPPPVVNLLEQHKKEIGFNPD
What are the official names of this protein?
YcgL domain-containing protein Spea_2443.
Protein: CCME_SHEON
Sequence: MNPRRKKRLTLAVALIGGVAAIASLLLYALNSNLNLFYTPSEIVNGKTDTGVKPEAGQRIRVGGMVTVGSMVRDPNSLHVQFAVHDSLGGEILVTYDDLLPDLFREGQGIVAQGVLGEDGKLAATEVLAKHDENYMPPEVAEAMGQKHEKLDYSQQKSATQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: ACT2_OXYTR
Sequence: MSDQQTCVIDNGSGVVKAGFAGEDAPRAVFPSIVGRPKNVSALIGVDSASEYLGDEAQQKRGVLKIFYPIEHGIVKDWDDMEKIWNHTFYVELRVQPDEHPILLTEAPLNPKTNREKMTQIMFETFNVPALYVVIQAVLSLYSAGSTTGIVCDAGDGVTHTVPIYEGFSIPHAVSRIQLAGRDLTTFMAKLLTERGYNFTSSAELEIVRDIKEKLCFVALEYESALKQSHDSSQFEKNYELPDGKVITIGSERFRCPEYLFKPLEMNGRELDSIQDLTYKSIQECDVDVRRDLYQNIIISGGTTMNEGIGERLLKEIENRAPKSINVKVIASADRIFAVWRGGSTRTSLSTFASMWITKEDYDENGASIVHRKCI
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoplasmic, Actin, micronuclear.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: K6PF_THEZI
Sequence: MVRELLEKARGLSIYTAYNTNVDAIVYLNGETVQRLIDEFGADAVRKRMEDYPREINEPLDFVARLVHALKTGKPMAVPLVNEELHTWFDSHFRYDVERMGGQAGIIANLLSNLDFREVIVYTPHLAKRQAEMFVRKPNLFYPVVEGGRLVLKHPWEAYREGDPVKVNRIFEFRAGTAFKLGDERIVVPFSGRFIVSARFESIRIYTEPGLRPFLPEIGERVDGAILSGYQGINLRYSDGKDANYYLRKAKEDIMLLKREKDLKVHLEFASIQSRELRKKVIYNLFPLADSVGMDEAEIAYVLSALGYDELADRIFTYNRIEDTVLGGKILLDEMNLDVLQIHTIYYIMYITHADNPLSEEELRRSLELATTLAASRASLGDITSPDQIEIGLRVPYNERGEYVKLRFEEAKRKLRTKEYKLVIIPTRLVQNPVSTVGLGDTISTGAFASYLAMLKEKGEL
What is the function of this protein?
Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
What are the official names of this protein?
ADP-specific phosphofructokinase, ADP-dependent phosphofructokinase, ADP-Pfk.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXPL6_DICDI
Sequence: MIKIIYLIVLLVLLFKNNHIIIKADDCPFPQIPIKTLSGTWYDDPDHASCGFEKLTGPLGPGNRLVVALGSKLFDKGANCGQCYDVTSPFNNKTITVMATDSCHDAGYCQADNHFDFYKEAFDLLGSPSGVISGNSGLSYIKVPCPTYGNVKIMMKDGSNEFWTSFLIFNSRILIKQVSIKLSNSQQFIDLNRQPQGNYWPSTNMVSGEFEVRIESIGGEFIYVKIPSIESRKIYDTGNQFSADGCVGNKYDPYAPFQITSNSNNILPPSLYIIFLISILFLIINNIFSNKY
What is the function of this protein?
May serve to lubricate the movement of the cellulose microfibrils during cell growth and wall extension and/or may serve to maintain the fluid state of the slug cell wall.
What are the official names of this protein?
Expansin-like protein 6, Ddexpl6.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PSBA2_NOSS1
Sequence: MTATLQQRKSANVWEQFCEWITSTNNRLYIGWFGVLMIPTLLAATTCFIIAFIAAPPVDIDGIREPVAGSLIYGNNIISGAVVPSSNAIGLHFYPIWEAASLDEWLYNGGPYQLVIFHFLTGVFCYLGREWELSYRLGMRPWICLAFSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLVRETTENESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRQLHFFLAAWPVIGIWFTALGVSTMAFNLNGFNFNQSIIDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAGEVAPVAISAPAING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1 2, PSII D1 protein 2, Photosystem II Q(B) protein 2.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: APC2_YEAST
Sequence: MSFQITPTRDLKVITDELQTLSSYIFHTNIVDDLNSLLTWMSPNDAKSNHQLRPPSLRIKNIIKVLFPNNATTSPYSMINTSQANNSIVNEGNTNKELQLQLFSTLKEFYIFQVRYHFFLHFNNINYLKDIQRWENYYEFPLRYVPIFDVNVNDWALELNSLRHYLLNRNIKFKNNLRTRLDKLIMDDDFDLADNLIQWLKSANGSLSSTELIVNALYSKINKFCEDNMSRVWNKRFMIMETFNKFINQYWSQFSKLVGCPEDDHELTTTVFNCFESNFLRIRTNEIFDICVLAYPDSKVTLLELRKIMKDFKDYTNIVTTFLSDFKKYILNPSVTTVDALLRYVKTIKAFLVLDPTGRCLHSITTFVKPYFQERKHLVNVLLYAMLDLPEEELKEKINFNVDMKALLSLVDTLHDSDINQDTNITKRDKNKKSPFLWNLKVKGKRELNKDLPIRHAMLYEHILNYYIAWVPEPNDMIPGNIKSSYIKTNLFEVLLDLFESREFFISEFRNLLTDRLFTLKFYTLDEKWTRCLKLIREKIVKFTETSHSNYITNGILGLLETTAPAADADQSNLNSIDVMLWDIKCSEELCRKMHEVAGLDPIIFPKFISLLYWKYNCDTQGSNDLAFHLPIDLERELQKYSDIYSQLKPGRKLQLCKDKGKVEIQLAFKDGRKLVLDVSLEQCSVINQFDSPNDEPICLSLEQLSESLNIAPPRLTHLLDFWIQKGVLLKENGTYSVIEHSEMDFDQAQKTAPMEIENSNYELHNDSEIERKYELTLQRSLPFIEGMLTNLGAMKLHKIHSFLKITVPKDWGYNRITLQQLEGYLNTLADEGRLKYIANGSYEIVKNGHKNS
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.  In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition.  In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
What are the official names of this protein?
Anaphase-promoting complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YQGF_HELPS
Sequence: MILACDVGLKRIGIAVLLNGVILPLEAILRHNRNQASRDLNDLLREKNIQVLVVGKPNESYADTNARIEHFIKLLDFKGEIVFINEDRSSIEAYENLGHLGKKNKRLAIKDGRLDSLSACGILERYCQQVLKNR
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIB_LEPCP
Sequence: MKNWPRLAFIAWVLLRQGMDQLVLSHMPHASLRLLARLMSIGRTHHEPRGVRLRMALERLGPIFVKFGQVLSTRRDLIPHDIANELAKLQDRVPPFPSDVSRAAVVQSLGRPIEEVFASFDADPVASASIAQVHFGVLHDGREVAVKVLRPNVLNIIEADLALLRVAAAWLERLSPDGRRLRPREVVAEFDNYLHDELDLGREAANAAQLRRNMGGLDLIMLPEMIWDLSSAEVLVMERMHGVPISQIETLRAAGIDIPKLARDGVTIFFTQVFRDGFFHADMHPGNIMVSTAPATFGRYIALDFGIVGTLDSRDKEYLAQNFLAFFRRDYRRVAELHIESGWVPASTRVDELEGAVRAVCEPHFDRPLKDISLGQVLLRLFQTSRRFNVEIQPQLVLLQKTLLNVEGLGRQLDPELDLWQTAKPFLERWMNEQVGWRALLGSIKDEAPRYAKLLPELPRLLHDALQAHARPQRPSDELLLALLHEQRRTNRLLLTVFYLIGGFVAGGLFAHWILPGLLHLL
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: VAC14_CHICK
Sequence: MNAERDLAPLAPSVVRALNDKLYEKRKVAALEIEKLVREFVAQNNTSQVKHVILILSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGSVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNQFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNSKEIRKMCEVALGEFLKEIKKNPSSVKFAEMANILVIHCQAADDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLSYDDRKKNIKEVANVCNQSLMKLVIPEDDEMDEAKQSITLSAEPNPEEPVSKPEAASTGSLDVSGDSSVSNASVCTVTSSERIQVTLNLDGIVQVLDCHLHDTSIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLRTLSDESDEVILKDLEVLAEIASSPAGQTEGYGPSEAAEPRPGQVELHVPIRNSQLSSSGPKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLETRGAFIIRQLCLLLNTENIFHSMADILLREEDLKFASTMVHTLNTILLTSSELFQLRNQLKDLRTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYKHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELMQSADGSRASASSRRPASSTIDYTELLQHFDKVQSKHLEVRHQRAGRAEQPERRVVL
What is the function of this protein?
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Pentamerizes into a star-shaped structure and nucleates the assembly of the complex.  The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P).  Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
What are the official names of this protein?
Protein VAC14 homolog.
What is the protein family that this protein belongs to?
Belongs to the VAC14 family.
What are the subcellular locations of this protein?
Endosome membrane. Microsome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
Protein: Y331_BORBU
Sequence: MSNLIFNKMYFLFLIFYLKFYSLDLRRIFLCKILSKIIIESYTLFMYFCFK
What are the official names of this protein?
Uncharacterized protein BB_0331.
Protein: KTHY_OENOB
Sequence: MKKGFFITIEGPDGAGKTSLLDNLMPALRDIFGDNLIETREPGGVRISEAIRKIVLGLKYPEMNRRTEALLFAAARAQHMVEKIEPALADGKIVLSDRFVDSSIAYQGGGRELGIEAVGEINNFATNGLQPNLTLLLDLPSEVGIARIMKHRSDEVNRLDKDRLVFHKKVRQTYLQLAKDQPNRIKVLDATQSPEKIAINALQLIQESLKGWI
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: TXC04_LYCSI
Sequence: MKFAVILLFSLVVLAVASESVEEVRREIDIEDLPEQQRGCADLRQPCTEGDDCSCCGSEGVCNCSHPHKKGCYCKTAGLLEKLAKKFKGCKNK
What are the official names of this protein?
U12-lycotoxin-Ls1d, Toxin-like structure LSTX-K4.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 31 family.
What are the subcellular locations of this protein?
Secreted.