PharMolix/UniProtQA huggingface dataset:
Protein: CNBP1_BOVIN
Sequence: MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTANEEEFLRTYAGVVNSQLSQLPQHSIDQGAEDVVMAFSRSETEDRRQ
What is the function of this protein?
Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
What are the official names of this protein?
Beta-catenin-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the CTNNBIP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y2324_YERPG
Sequence: MPITANTLYRDSFNFLRNQIAAILLLALLTAFITVMLNQTFMPASEQLSILSIPENDITSSGNLSISEIVSQMTPEQQMVLLRVSAVATFSALVGNVLLVGGLLTLIAMVSQGRRVSALQAIGLSLPILPRLLVLMFISTLVIQLGLTFFIVPGVAIAIALSLSPIIVTNERMGIFAAMKASAQLAFANVRLIVPAMMLWIAVKLLLLFLISRFTVLPPTIATIVLSTLSNLASALLLVYLFRLYMLLRPVSLDKQ
What are the official names of this protein?
UPF0259 membrane protein YpAngola_A2324.
What is the protein family that this protein belongs to?
Belongs to the UPF0259 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DPP10_HUMAN
Sequence: MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE
What is the function of this protein?
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437).  Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437).  Has no dipeptidyl aminopeptidase activity (PubMed:12662155).
What are the official names of this protein?
Inactive dipeptidyl peptidase 10, Dipeptidyl peptidase IV-related protein 3, DPRP-3, Dipeptidyl peptidase X, DPP X, Dipeptidyl peptidase-like protein 2, DPL2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family. DPPIV subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: DRL16_ARATH
Sequence: MGNFVCIEISGDQMLDRIIRCLCGKGYIRNLEKNLRALQREMEDLRATQHEVQNKVAREESRHQQRLEAVQVWLDRVNSIDIECKDLLSVSPVELQKLCLCGLCSKYVCSSYKYGKRVFLLLEEVTKLKSEGNFDEVSQPPPRSEVEERPTQPTIGQEEMLKKAWNRLMEDGVGIMGLHGMGGVGKTTLFKKIHNKFAETGGTFDIVIWIVVSQGAKLSKLQEDIAEKLHLCDDLWKNKNESDKATDIHRVLKGKRFVLMLDDIWEKVDLEAIGIPYPSEVNKCKVAFTTRDQKVCGQMGDHKPMQVKCLEPEDAWELFKNKVGDNTLRSDPVIVGLAREVAQKCRGLPLALSCIGETMASKTMVQEWEHAIDVLTRSAAEFSDMQNKILPILKYSYDSLEDEHIKSCFLYCALFPEDDKIDTKTLINKWICEGFIGEDQVIKRARNKGYEMLGTLIRANLLTNDRGFVKWHVVMHDVVREMALWIASDFGKQKENYVVRARVGLHEIPKVKDWGAVRRMSLMMNEIEEITCESKCSELTTLFLQSNQLKNLSGEFIRYMQKLVVLDLSHNPDFNELPEQISGLVSLQYLDLSWTRIEQLPVGLKELKKLIFLNLCFTERLCSISGISRLLSLRWLSLRESNVHGDASVLKELQQLENLQDLRITESAELISLDQRLAKLISVLRIEGFLQKPFDLSFLASMENLYGLLVENSYFSEINIKCRESETESSYLHINPKIPCFTNLTGLIIMKCHSMKDLTWILFAPNLVNLDIRDSREVGEIINKEKAINLTSIITPFQKLERLFLYGLPKLESIYWSPLPFPLLSNIVVKYCPKLRKLPLNATSVPLVEEFEIRMDPPEQENELEWEDEDTKNRFLPSIKPLVRRLKIHYSGMGFLNVKNQNPRFFFYCFIYLLVVHLDCIIDLHSDTSGMCCVVHLDYVFHFPFVFPKTFCILFRLHFYTIKSLCV
What is the function of this protein?
Probable disease resistance protein.
What are the official names of this protein?
Probable disease resistance protein At1g61190.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
Protein: GALT6_BOVIN
Sequence: MRLLRRRHMAVRLVMVGSAFVLFLFILQRDVSGREQATEKPWLRSLVSQKDHVLDLMLGAVHNLRDSMPKFQIRAPEPQQTLASTNQSCLPGFYTPAELKPFWERPPQDPNGPGADGKAFQKKEWTPQETQEKEEGYKKHCFNAFASDRISLQRALGPDTRPPECVDQKFRRCPPLPATSVIIVFHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTDEYLKEPLERYVKQLQVVQVVRQQERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDETVVVSPNIVTIDLNTFEFSKPVQRGRVQSRGNFDWSLTFGWEVLPAREKQRRKDETYPIKSPTFAGGLFSISKSYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGINVIARNQVRLAEVWMDGYKEIFYRRNLQAAQMAREKSFGDISERLQLRERLNCHNFSWFLDNVYPEMFVPDLKPTFFGALKNLGVDHCLDVGENNNGGKPLILYTCHGLGGNQYFEYTTQRDLRHNIAKQLCLHASAGTLGLRSCHFTGKNSQVPKDEEWEFTQDQLIRNSGSGTCLTSKDKKPVMATCNPSDPHQHWLFI
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.  May participate in synthesis of oncofetal fibronectin.  Has activity toward MUC1A, MUC2, EA2 and fibronectin peptides (By similarity).
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase 6, Polypeptide GalNAc transferase 6, GalNAc-T6, pp-GaNTase 6, Protein-UDP acetylgalactosaminyltransferase 6, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: GCST_ARATH
Sequence: MRGGSLWQLGQSITRRLAQSDKKVVSRRYFASEADLKKTALYDFHVAHGGKMVPFAGWSMPIQYKDSIMDSTVNCRENGSLFDVAHMCGLSLKGKDCVPFLETLVVADVAGLAPGTGSLTVFTNEKGGAIDDSVITKVTDEHIYLVVNAGCRDKDLAHIEEHMKAFKSKGGDVSWHIHDERSLLALQGPLAAPVLQHLTKEDLSKLYFGNFQILDINGSTCFLTRTGYTGEDGFEISVPDEHAVDLAKAILEKSEGKVRLTGLGARDSLRLEAGLCLYGNDMEQHISPVEAGLTWAIGKRRRAEGGFLGADVILQQLKDGPTIRRVGFFSSGPPARSHSEVHDESGNKIGEITSGGFSPNLKKNIAMGYVKSGQHKTGTKVKILVRGKPYEGSITKMPFVATKYYKPT
What is the function of this protein?
The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, mitochondrial, Glycine cleavage system T protein, GCVT.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ATPE_RHOCA
Sequence: MADTMQFDLVSPERRLASVAASEVRLPGVEGDLTAMPGHAPVILSLRPGILTVVSAAGTAEYAVTGGFAEVSGEKVTVLAERGLTRAELTAAVHAEMLAEAKKVADAAHPSVADAAAKMLADMEALGSHINL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cellular chromatophore membrane; Peripheral membrane protein.
Protein: YNBC_ECOLI
Sequence: MENSRIPGEHFFTTSDNTALFYRHWPALQPGAKKVIVLFHRGHEHSGRLQHLVDELAMPDTAFYAWDARGHGKSSGPRGYSPSLARSVRDVDEFVRFAASDSQVGLEEVVVIAQSVGAVLVATWIHDYAPAIRGLVLASPAFKVKLYVPLARPALALWHRLRGLFFINSYVKGRYLTHDRQRGASFNNDPLITRAIAVNILLDLYKTSERIIRDAAAITLPTQLLISGDDYVVHRQPQIDFYQRLRSPLKELHLLPGFYHDTLGEENRALAFEKMQSFISRLYANKSQKFDYQHEDCTGPSADRWRLLSGGPVPLSPVDLAYRFMRKAMKLFGTHSSGLHLGMSTGFDSGSSLDYVYQNQPQGSNAFGRLVDKIYLNSVGWRGIRQRKTHLQILIKQAVADLHAKGLAVRVVDIAAGHGRYVLDALANEPAVSDILLRDYSELNVAQGQEMIAQRGMSGRVRFEQGDAFNPEELSALTPRPTLAIVSGLYELFPENEQVKNSLAGLANAIEPGGILIYTGQPWHPQLEMIAGVLTSHKDGKPWVMRVRSQGEMDSLVRDAGFDKCTQRIDEWGIFTVSMAVRRDN
What are the official names of this protein?
Uncharacterized protein YnbC.
Protein: POXB_PENOX
Sequence: MSEAEPSVVVAEQCRRSACDRCRGQKLRCERPVSNSSTTPCRRCLKAHVRCVTTAQPHRTKPLSSLQYLHHTESNYDPHSATVAGQLPVAAVAGLGDLDPSLLHMTGVQNPRRLSHSSSMANPVDSRPPGRTRRLSNPDHFLPHPPLHPNGVLDTDGTPLLDSIDHLPDMTASRGFGFSAALTPHSPSGSSDFFDYFRPMAEDNNRSPWMDAFTNLPPDHREGTPAGSNYRGSLTGENQFRSSLQSSRGLNGFETPQRESRHREMDIVSIKNECIARMGKLNRGLLQDVGLVNSGKVAGTLLFSQASRSTYLEVEKGRKGGQNYVIGKMLHSSKELLDILKQLERCKSTLFPPGHTERTTSTADEVTTAMTETTTLNQTGSHAPSSPLGGNPLPPLSGPLSASASHSSSCASSSSASASTSGASLLSSSTSAPSTSPAISLQLDTTLTLLFLTGYTSVIQLYEGVFSFIRDSVAANPSGSNFLPTLPKLQVDGFEVGSSTRDLQICILLQVSTHILNQIEERLHAIRDRAEGHVPAALLDTILDRSDPSQRGAKGRELCRIVRDIKEHLKHYAE
What is the function of this protein?
Transcription factor that positively regulates the expression of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety.
What are the official names of this protein?
C6 finger transcription factor poxB, Oxaleimides biosynthesis cluster protein B.
What are the subcellular locations of this protein?
Nucleus.
Protein: UPP_AGRVS
Sequence: MDGVTVINHPLVQHKLTFMRRKETSTAGFRRLLREISTLLCYEVTRDLELTVETIETPMVEMEAPVLEGKKLVFASILRAGNGLLEGMLDLVPSARVSHVGVYRDHETLQAVEYYFKAPESLSERLVIVVDPMLATGNSSIAAVDKLKERGAVNLRFVCLLAAPEGIKNFREAHPDVHVYTAAIDSHLNEHGYIVPGLGDAGDRMYGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MURG_PSESM
Sequence: MDANVLIMAGGTGGHVFPALACAREFQARGYKVHWLGTPRGIENELIPQAGLPLHLINVTGLRGKGRLSLLKAPFMLLKALMQARKVVRQVKPVCVVGFGGYVTGPGGLAARLAGVPLIIHEQNAVAGTANRSLASFASRVCEAFPNTFAASAKRRTTGNPVRVELFLETPRQALAGRKARLLVLGGSLGAEPLNKLLPDALAQLPQDIQPEVFHQSGKNHDAVTAERYRNVGVEAQVAPFIQNMAQAYSWADLVVCRAGALTISELAAAGLPSLLIPLPHAIDDHQSRNADYLAREGAAFVMPQATTGAAEMAARLKEVLMQPEQLNSMARTARSLAKPDATNTVVNVCVEVAHG
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YEGS_ECOBW
Sequence: MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARYVEEARKFGVATVIAGGGDGTINEVSTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGDAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGSVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHDITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_RUMCH
Sequence: MDIRQLCGNAGVASVKMAALSGEVKNNALMKIADALLANSKRIIEANQHDLERSEKENLASPLLKRLKFDEKKINDVVEGIKSLMALEEPIGKTLLANKLDDELELYKVTCPIGVIGIIFESRPDALVQISTLCLKSGNCVLLKGGSEAKETNRVLTGVIEEATVAAGLPKGWIGLLESRDDVNEMLKMDQFIDLIIPRGSNDFVRYIMDNSRIPVMGHADGICHVYVDESADLEMAKKITVDSKTQYVAVCNATETLLVDRAVAKEFLPGLKAELDKKNVEIFGDEETADIIEVKPASDQDWATEYLDYIISIKIVAGMDEAIKHIITYGSGHTDCIVTKDKAKAVNFMNLVDSGNVFWNASTRFSDGFKYGFGAEVGISTSKLHARGPVGLDGLLSYKYMLIGNGQIVDDYATNKRQFKHERMNKQIDEI
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_LAWIP
Sequence: MNIRKKTRKIYIGNIAIGGDAPIIVQSMTNTDTRDIEATLKQINQLHAVGCEIVRLAVPDANAAKALKAIHDASPLPLIADIHFDYRLALTALESGIEGLRINPGNIGERKKVVTVVDAAKAHKASIRIGVNSGSVEKHLIDKFGGPVPEAMVESALNHIKILEDEKFYEIKVSIKSSSVLDTIAAYRMLSKSCDYPLHLGVTEAGSLIRGTVKSSVGLGILLSEGIGDTLRISLTEDPVEEVPVAWEILRALGLRRRGPEIIACPSCGRAEIDLIRLTKDVEACLVNEKTPLKIAVMGCVVNGPGEAKEADIGIAGGRDKGIIFAKGKVIRSVHGQDKLLNVFMEEVNKVIAEYNTTQ
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: HICDH_THET8
Sequence: MAYRICLIEGDGIGHEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSVPEETVEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKSRPVPGSRPGVDLVIVRENTEGLYVEQERRYLDVAIADAVISKKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAPSGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEALKSL
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidative decarboxylation of homoisocitrate to 2-oxoadipate (alpha-ketoadipate), a reaction involved in lysine biosynthesis through the alpha-aminoadipate pathway (PubMed:21813504).  In addition, has high activity with isocitrate, but is inactive with 3-isopropylmalate (By similarity).
What are the official names of this protein?
Isocitrate/homoisocitrate dehydrogenase, Homoisocitrate dehydrogenase, HICDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: S72L4_HUMAN
Sequence: MLSSTLRVAVVCVSNVNRSMEAHSILRRKGLSVRSFGTESHVRLPGPRPNRPVVYDFATTYKEMYNDLLRKDRERYTRNGILHILGRNERIKPGPERFQECTDFFDVIFTCEESVYDTVVEDLCSREQQTFQPVHVINMDIQDTLEDATLGAFLICEICQCLQQSDDMEDNLEELLLQMEEKAGKSFLHTVCFY
What is the function of this protein?
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II.  Plays a role in RNA processing and termination.
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 4, RNA polymerase II subunit A C-terminal domain phosphatase SSU72L4, CTD phosphatase SSU72L4.
What is the protein family that this protein belongs to?
Belongs to the SSU72 phosphatase family.
Protein: RL10_CHLPN
Sequence: MKQEKTLLLQEVEDKISAAQGFILLRYLRFTAAYSREFRNSLSGVSAEFEVLKKRIFFKAIEAAGLEVDCSDTDGHLGVVFSCGDPVSAAKQVLDFNKQHKDSLVFLAGRMDNASLSGAEVEAVAKLPSLKELRQQVVGLFAAPMSQVVGIMNSVLSGVISCVDQKAGKN
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: HLDE_HAEI8
Sequence: MAQYSAEFKQAKVLVLGDVMLDRYWFGATNRISPEAPVPVVRVQENEERAGGAANVAMNIASLNVSVQLMGLIGQDETGSALSLLLEKQKIDCNFVALETHPTITKLRILSRHQQLLRLDFEEDFNNVDCKDLLAKLESAVKNYGALILSDYGKGTLKDVQKMIQIARKANVPVLIDPKGTDFERYRGATLLTPNMSEFEAVVGKCNTEEEIIKKGLKLISDIELTALLVTRSEKGMTLLRPNQEPYHLPTVAKEVFDVTGAGDTVISVLATALADGRSFEESCYLANVAAGIVVGKLGTSTVSTVELENAIHARPETGFGIMSEAELKDAVAQAKARGEKIVMTNGCFDILHPGHISYLENARKLGDRLIVAVNSDDSVKRLKGESRPINNLENRMAVLAGLASVDWLVPFTEDTPQRLIGEILPDLLVKGGDYKPEEIAGSKEVWANGGDVKVLNFENGCSTTNVIEKIKLLKD
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: PDLI3_XENLA
Sequence: MPQNVLLPGPAPWGFRLTGGIDFNQPLVISRITPGSKSSVANLCPGDVILAIDGFSTETMTHAEAQDRIKAATDQLCLKIDRAETRIWSPQVCEDGKAQPFKINLEAEPQDLGFFEHKHNIRPKPFILPGRSSGSSTPSGFDPGSGRSTPSSVSTIDPVELKAASRIAPNVPLEMELPGVKIVHAQFNTPMQLYSDDNIMESLQGQVSTILGEKTPMSDPVPPSVPQSDVYKLLHDDTEHPSKPRQSGSFKILQDMVDDDPDRPSGTRSVRAPVTKPNTGAAAVQKVPICDRCGNGIVGTVVKAKDKLRHPDCFVCSDCNLNLKQKGYFFVEGQLYCEAHARARMRPPEGYDAVTVYH
What is the function of this protein?
May play a role in the organization of actin filament arrays within muscle cells.
What are the official names of this protein?
PDZ and LIM domain protein 3.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.
Protein: HFA1_YEAS1
Sequence: KGKTITHGQSWGARRIHSHFYITIFTITCIRIGQYKLALYLDPYRFYNITGSQIVRLKGQRPEYRKRIFAHSYRHSSRIGLNFPSRRRYSNYVDRGNIHKHTRLPPQFIGLNTVESAQPSILRDFVDLRGGHTVISKILIANNGIAAVKEMRSIRKWAYETFNDEKIIQFVVMATPDDLHANSEYIRMADQYVQVPGGTNNNNYANIDLILDVAEQTDVDAVWAGWGHASENPCLPELLASSQRKILFIGPPGRAMRSLGDKISSTIVAQSAKIPCIPWSGSHIDTIHIDNKTNFVSVPDDVYVRGCCSSPEDALEKAKLIGFPVMIKASEGGGGKGIRRVDNQDDFIALYRQAVNETPGSPMFVMKVVTDARHLEVQLLADQYGTNITLFGRDCSIQRRHQKIIEEAPVTITKPETFQRMERAAIRLGELVGYVSAGTVEYLYSPKDDKFYFLELNPRLQVEHPTTEMISGVNLPATQLQIAMGIPMHMISDIRKLYGLDPTGTSYIDFKNLKRPSPKGHCISCRITSEDPNEGFKPSTGKIHELNFRSSSNVWGYFSVGNNGAIHSFSDSQFGHIFAVGNDRQDAKQNMVLALKDFSIRGEFKTPIEYLTELLETRDFESNNISTGWLDDLILKNLSSDSKLDPTLAIICGAAMKAYVFTEKVRNKYLELLRRGQVPPKDFLKTKFPVDFIFDNNKYLFNVAQSSEEQFILSINKSQCEVNVQKLSSDCLLISVDGKCHTVYWKDDIRGTRLSIDSNTIFLEAELNPTQVISPTPGKLVKYLVRSGDHVFAGQQYAEIEIMKMQMPLVAKSDGVIELLRQPGSIIEAGDVIAKLTLDSPSKANESSLYRGELPVLGPPLIEGSRPNHKLRVLINRLENILNGYHENSGIETTLKELIKILRDGRLPYSEWDSQISTVRNRLPRQLNEGLGNLVKKSVSFPAKELHKLMKRYLEENTNDHVVYVALQPLLKISERYSEGLANHECEIFLKLIKKYYAVEKIFENHDIHEERNLLNLRRKDLTNLKEILCISLSHANIVAKNKLVTAILHEYEPLCQDSSKMSLKFRAVIHDLASLESKWAKEVAVKARSVLLRGIFPPIKKRKEHIKTLLQLHIKDTGAENIHSRNIYSCMRDFGNLIHSNLIQLQDLFFFFGHQDTALSSIASEIYARYAYGNYQLKSIKIHKGAPDLLMSWQFSSLRNYLVNPDGESDGFTKLSKPPSTSGKSSANSFGLLVNMRALESLEKTLDEVYEQIHIPEERLSSGENSLIVNILSPIRYRSENDLIKTLKIKLHENERGLSKLKVNRITFAFIAANAPAVKFYSFDGTTYDEIPQIRNMDPSYEAPLELGKMSNYKIRSLPTYDSSIRIFEGISKFTPLDKRFFVRKIINSFMYNDQKTTEENLKAEINAQVVYMLEHLGAVDISNSDLNHIFLSFNTVLNIPVHRLEEIVSTILKTHETRLFQERITDVEICISVECLETKKPAPLRLLISNKSGYVVKIETYYEKIGKNGNLILEPCSEQSHYSQKSLSLPYSVKDWLQPKRYKAQFMGTTYVYDFPGLFHQAAIQQWKRYFPKHKLNDSFFSWVELIEQNGNLIKVNREPGLNNIGMVAFEIMVQTPEYPEGRNMIVISNDITYNIGSFGPREDLFFDRVTNYARERGIPRIYLAANSGAKLGIAEELIPLFRVAWNDPSDPTKGFQYLYLAPKDMQLLKDSGKGNSVVVEHKMVYGEERYIIKAIVGFEEGLGVECLQGSGLIAGATSKAYREIFTITAVTCRSVGIGSYLVRLGQRTIQVEDKPIILTGASAINKVLGTDIYISNLQIGGTQIMYKNGIAHLTASNDMKAIEKIMTWLSYVPAKRDMSPPLLETMDRWDRDVDFKPAKQVPYEARWLIEGKWDSNNNFQSGLFDKDSFFETLSGWAKGVIVGRARLGGIPVGVIAVETKTIEEIIPADPANLDSSEFSVKEAGQVWYPNSAFKTAQTINDFNYGEQLPLIILANWRGFSGGQRDMYNEVLKYGSFIVDALVDYKQPILIYIPPFGELRGGSWVVIDPTINPEQMEMYADVESRGGVLEPDGVVSIKYRKEKMIETMIRLDSTYGHLRRTLTEKKLSLEKQNDLTKRLKIRERQLIPIYNQISIQFADLHDRSTRMLVKGVIRNELEWKKSRRFLYWRLRRRLNEGQVIKRLQKKTCDNKTKMKYDDLLKIVQSWYNDLDVNDDRAVVEFIERNSKKIDKNIEEFEISLLIDELKKKFEDRRGNIVLEELTRLVDSKRKR
What is the function of this protein?
Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway.  Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid.  This protein carries three functions: biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase (By similarity).
What are the official names of this protein?
Acetyl-CoA carboxylase, mitochondrial, ACC.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PANX3_HUMAN
Sequence: MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
What is the function of this protein?
Structural component of the gap junctions and the hemichannels.
What are the official names of this protein?
Pannexin-3.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: THIC_STRGG
Sequence: MTTADARTPASKQNDGTPDGTTPDAGTPNDGAGKSIGWHKGYVQGSRPDLRVPVRQVHLTNGKHVTLYDTSGPYTDASVDTDVRRGLAPLRENWIIARGDTEEYAGRPVRPEDDGLKHTSPRGGLRNLDAVFPGRPRQPRRSRDGRPVTQLAYARRGEVTPEMEYVAIRENVEAEVVREEIAAGRAVLPANVNHPEIEPMIIGKRFLVKVNANIGNSAVTSSIEEEVDKMTWATQWGADTVMDLSTGRNIHTTREWVLRNSPVPIGTVPLYQALEKVDGRAEELTWEIYKDTVIEQAEQGVDYMTVHAGVRLPYVPLTARRKTGIVSRGGSIMAAWCLAHHKESFLYEHFEELCEILATYDVTYSLGDGLRPGSIADANDEAQFAELRTLGELNTVAKRFGVQTMIEGPGHVPMHKIKENIDLQQEICEEAPFYTLGPLTTDVAPAYDHITSGIGAAMIAWWGTAMLCYVTPKEHLGLPNRDDVKTGVITYKIAAHAADLAKGHPGAQEWDDALSDARFEFRWEDQFNLALDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMKISQDIRRQHGGSREEIEEGMAEKSKEFAAAGNRVYLPIAD
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: TRI69_RAT
Sequence: MEVSSRPPSNFDPGNYVEVSDPSTHLPSKVVIQDITTELHCPLCNDWFRDPLMLTCGHNFCQACIQNYWKMQAKETFCPECKMLCQYSNCTFNLVLEKLVEKIKRLPLLKGHPQCPEHGENLKLFSKPDGKMICFQCKDARLSMGQSKDFLQISEAVRFFTEELAIYQSQLQTTLKELQSLRTMQKDAIAAYKDNKIQLQQNLSLEFLKLHQFLHNKEKDILNDLRDEGKVLNEEMDANLNQIQEQCLLAKDMLANIQARMEQQNSFDFLTDITKLLENMEKGMKTLVPRQLISKKLSLGRFKGPIQYTIWREMQSILSPGPSQLTLDPKTAHPNLVLSNSRTSVCHGDVKQVMPDDPERFDSSVAVLGSKGFTSGKWYWEIEVAKKTKWTIGIVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSCSLNLGDLRRVGVYLDYEGGQVSFYNATNMTHLYTFTSVFLEKLFPYLCPCLNDGGENKEPLHIVHPQ
What is the function of this protein?
E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus.  Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection.  In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity.  Plays also a role in cataract formation together with TP53.  Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination.
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM69, RING finger protein 36, RING-type E3 ubiquitin transferase TRIM69, Tripartite motif-containing protein 69.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle.
Protein: YACG_NITHX
Sequence: MPARKPAGARPEKPCPICGKPAVAASRPFCSERCRDVDLNRWLSGSYVIPVSKTDGEDAE
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: RL17_VIBVY
Sequence: MRHRKSGRQLNRNSSHRKAMFSNMASSLVRHEVIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEVVAKLFNELGPRFAARQGGYTRILKAGFRAGDKAPMAYIELVDRPAAEEAAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.