PharMolix/UniProtQA huggingface dataset:
Protein: DRC3_RAT
Sequence: MSRPYDSMEPKVMDDDMLKVAVGEQGPQEEAGQLAKQEGILFKDVLALQLDFQNILRIDNLWQFENLRKLQLNNNIIERIEGLENLTHLVWLDLSFNNIEAIEGLDTLVNLEDLSLSHNRISKIDSLDPLVNLQVLSLGNNQINNMMNIIYLRRFPCLRTLSLSGNPVSEAEEYKVFIYAYLPDLVYLDFRRVDEQAREVAKMKHQYSIDELKHREALMQIRLEEEQAKQQKLAEHKMAFVEHLNGPFLFDSMYSDDVEGNKLSYLPGVGELLEAYKDKFVIICLNIFEYGLSQQEKRKIELDTFNECIQEAIQENQDQGKLKIAKFEEKHLLNLNAIREESDLFTMEQKLTECNESITELFNTLMILEMQLVEQLEETINVFERNITDLVGLFIENVQSLIAQCRDLENHHHEKLLEIAINTLEKILKGEMDEDLPDDVRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTGVNSWCAHLVDKIHKDEIMRNRKRVKEINQFVDHMQSELDNLECGDIID
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
What are the official names of this protein?
Dynein regulatory complex subunit 3, Leucine-rich repeat-containing protein 48.
What is the protein family that this protein belongs to?
Belongs to the DRC3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme. Cell projection, cilium, flagellum.
Protein: MNMG_AFIC5
Sequence: MRKTFDVIVVGGGHAGCEAAAASARLGAETALLTHRFATVGAMSCNPAIGGLGKGHLVREIDALDGLMGRMADTGGIQFRVLNRRKGPAVRGPRAQIDRALYAAAMQAEIRATPHLSVIEGEADALVLKDDRIAGLKLADGREFSCRAVVITTGTFLRGIIHLGETSWPAGRINEAPAMGLSKSFEQIGFTLGRLKTGTPARLDGTTIDWAAVERQPGDDPAEPFSTLTEEITTPQVECGITRTTTATHAVIRENVHRSPLYSGQIQSIGPRYCPSIEDKIVRFGDRDSHQIFLEPEGLKDTTVYPNGISTSLPEEVQKAILTTIPGLERTRMIRPGYAIEYDHVDPRELEPTLETRRVPGLFLAGQINGTTGYEEAAAQGLVAGLNAARTAGGKEGVIFDRADGYLGVMIDDLTSRGVTEPYRMFTSRAEYRLTLRADNADQRLTWRGLALGVVGFARQAQFDAKMRALDAAKEAAKSLSLTPTEGIRHGLALNRDGQRRSAFELLAYPEIGWADVARIWPQLAEVTPDIAEHVEIDAKYDVYLARQAADVSAFRRDEALVLSGVDYADVPGLSNEARQKLQKAQPRTIGQAARIEAMTPAALGILTAYLRRRSRHRSDAKAG
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCAKD_XENTR
Sequence: MFLVGLTGGIASGKSTVVSILRELGCAVIDADLIARQVVRLGTPAYSQIVQHFGDGVLLVSGELDREKLGAIIFSDPEKRCVINSITHPQIRREMLRQTLWYFFLGYRYVILDIPLLFESRSMTRYMKHTMLVYCDPQTQLERLMRRNSLSRDEATKRIAAQLPLDSKLPLADHVIDNSGDRDNTRRQVLQLHARLESSLAYLPVRITAATVATGLVVLACGLLRRLWQ
What are the official names of this protein?
Dephospho-CoA kinase domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
Protein: GLPD_STAAS
Sequence: MALSTFKREHIKKNLRNDEYDLVIIGGGITGAGIALDASERGMKVALVEMQDFAQGTSSRSTKLVHGGLRYLKQFQIGVVAETGKERAIVYENGPHVTTPEWMLLPMHKGGTFGKFSTSIGLGMYDRLAGVKKSERKKMLSKKETLAKEPLVKKEGLKGGGYYVEYRTDDARLTIEVMKRAAEKGAEIINYTKSEHFTYDKNQQVNGVKVIDKLTNENYTIKAKKVVNAAGPWVDDVRSGDYARNNKKLRLTKGVHVVIDQSKFPLGQAVYFDTEKDGRMIFAIPREGKAYVGTTDTFYDNIKSSPLTTQEDRDYLIDAINYMFPSVNVTDEDIESTWAGIRPLIYEEGKDPSEISRKDEIWEGKSGLLTIAGGKLTGYRHMAQDIVDLVSKRLKKDYGLTFSPCNTKGLAISGGDVGGSKNFDAFVEQKVDVAKGFGIDEDVARRLASKYGSNVDELFNIAQTSQYHDSKLPLEIYVELVYSIQQEMVYKPNDFLVRRSGKMYFNIKDVLDYKDAVIDIMADMLDYSPAQIEAYTEEVEQAIKEAQHGNNQPAVKE
What are the official names of this protein?
Aerobic glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FSHB_MACFA
Sequence: MKTVQFCFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPNIQKTCTFKEVVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFSEMKE
What is the function of this protein?
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer.  Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:10612425).  Follitropin is involved in follicle development and spermatogenesis in reproductive organs (By similarity).
What are the official names of this protein?
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted. Note=Efficient secretion requires dimerization with CGA.
Protein: UVRC_MYCGE
Sequence: MTTNLKQKLKTAPKKPGCYLWKDSNGKVLYVGKASNIFNRVHQYFQKNNPYKTQLLSSQISDVDFFILKDENDALNLEAKLINQYQPRFNLVLKQNNGYLYFYITKAKKPTLELARKYQIKTTKCFGPFASSKFKLREIHDLLLKLFPLRKCAPHQKNHPCFYFQMGLCMGQCMQTDTKEKYQQVISNIEQFFNDPSVVINYLKAAEKKASDNQEFEKAQQFLTLQKAVLELTKTHHTTIIKQKSSHDFIGYVFQNNVLAITIFCYEKGELTDKEQAVFTLEQTDIVEVESAIITFIYHHYKTTPLPSKITVSLDETNLKLISDSLKIGVFKPKNGNEKLILQTVIDNAKHALATKWLKFTSNYDKTQLHKDLAQLLNTDYIHSLEIIDVSFYDQNHVVGCMLRFEDGKKIKHLSRRYNINSLKKGDTNHIALLVYRRILSAMQTKANLPFSDLLIIDGGKAQIKSVKQVFSLFSNVKPPIIIGLVKNKNHQTDHIMLSDFQVKKIAINSPLFHYLATIQTEVDGFAKRSAFNKLSNHQLQNPLLQIPGVGKITAQILFDNFQTLNNIKLASVNELSQFIKKPLAQKIKTYFAKQTD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IEND3_USTMA
Sequence: MDGEVKSYWFKTFSHKSFSVIWDLFYNTSNGVTKKTINSGTILNHLNEVGLAYWVMGDGSLHREGRVLTLHTQGFSHDENKMMSEELNLKFGFKSKVVKHKNKFVVQFTTSDANKLHDLIKPYLIPTMQYKLPRKL
What is the function of this protein?
Mitochondrial DNA endonuclease involved in intron homing.
What are the official names of this protein?
Probable intron-encoded DNA endonuclease 3.
What is the protein family that this protein belongs to?
Belongs to the LAGLIDADG endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: IP21_CAPAN
Sequence: RICTNCCAGRKGCNYYSADGTFICEGESDPNNPKACPRYCDTRIAYSKCPRSEGN
What is the function of this protein?
Potent inhibitor of trypsin and a weaker inhibitor of chymotrypsin and pronase E.
What are the official names of this protein?
Proteinase inhibitor PSI-1.1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I20 (potato type II proteinase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: AROB_LISMC
Sequence: MPEITVRAKSKTYPVYINEFALEDVREKWTESLAKFSHVFVLTDEHVAELHKAKLDAVLADLPVVTYYVAPNGEEAKTFRVYEDVMTKLIETGLDRKAVLIAFGGGVIGDLGGFVAATYMRGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQPEAVIYDTQFFATLPEREMRSGFAEMIKHALISDQTLLRALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVRAYLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETIYGLDFDLAEFKTWLKQLGYDTTFDATVPFNKILENMRHDKKTTFNEISMVLLEEIGKPVIFKAEDDLIFETYKRVMRNGGNGI
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TR12A_MOUSE
Sequence: MASQFMKNLKEEVTCPVCLNLMVKPVSADCGHTFCQGCITLYFESIKCDKKVFICPVCRISYQFSNLRPNRNVANIVERLKMFKPSPEEEQKVFNCARHGKKLQLFCRKDMMAICWLCERSQEHRGHKTALIEEVAQEYKEQLQVVLQRLMADKKKFENWKDDLQKDRTYWENQIQKDVQNVRSEFKRMRDIMDSEEKKELQKLRQEKEDILNNLAESESEHAQQSKLLEDFISDVEHQLQCSDIEILQVRLQDVPGSESQKAWKPLPFLSAAVVFLVMTVSSS
What are the official names of this protein?
Tripartite motif-containing protein 12A.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
Protein: ATP6_HISS2
Sequence: MAGHTTADYISHHLTFLTTGQGFWNVHLDTLFFSLVSGVLFLFFFYRIASKATSGVPGKFQCLVEMLVEWVDGVVKDNIHGSDVRHQIGSLALTIFCWVFIMNAIDLIPVDFPPQFAELLGIHYLRAVPTADISATLGMSVCVFALIIFYTIKSKGLGGFVKEYTLHPFNHWAFIPVNFLLEAVTLLAKPISLAFRLFGNMYAGELIFVLIAVMYMADNIIPQVLGIPLHLIWAIFHILVITLQAFIFMMLTVVYLSIAYNKSDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CLPX_POLNS
Sequence: MSDTNNTNSSDKVLFCSFCGKSQYEVKKLIASPSVFICDECIDLCTDIIQEEINKLPREDSDDSLPTPHQIRKNLDQYVIGQDHAKKTLAVAVYNHYKRLQYLPKPKKEKLDKDGKPVEGSDKKESKLPAKAMVDDVELAKSNILLIGPTGSGKTLLAQTLARMLDVPFVMADATTLTEAGYVGEDVENIIQKLLQACDYNVEKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLVEGTMASVPPQGGRKHPNQDFLQVDTTNILFICGGAFDGLEKVIQQRTAKTGIGFNATVPGKDDRGVSDLLIEVEPEDLIKFGLIPELIGRLPVVATLAQLDEEALIQILTEPKNALVKQYQALLTMEGSELEVRREALSAIAKKAIARKTGARGLRSILEGSLMDVMYDLPSLKNVQKVIIDESSIADGGKPLLVYKQKVDHADLSKKA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: C5IT4_AMBAM
Sequence: MRAFVALFCTLVAFATVICDIQEHGHSYLTRNVTVENGACIFERNTLPDGETKALHDPCVIATCYAARREVNATLCRNFGVDPGCRFHWRNDGVYPQCCPTQVCDGTD
What is the function of this protein?
Complement inhibitor (PubMed:31871188).  Prevents complement-mediated activation of C5 by sterically preventing direct binding of C5 to its convertase (binding with domains MG4 and MG5) (PubMed:31871188) (By similarity).  Binds C5 at a different binding site than the other tick complement inbibitors OmCI and RaCI3, and the drug eculizumab (By similarity).  Inhibits the complement in human, rat and guinea pig, and also shows a reduced inhibition in rabbit and pig (By similarity).
What are the official names of this protein?
Complement inhibitor CirpT4.
What is the protein family that this protein belongs to?
Belongs to the CirpT family.
What are the subcellular locations of this protein?
Secreted.
Protein: SRRT_ANOGA
Sequence: MGDSDDEYDRKRRDKFRGERSAGGGGDSYGRGADRPDRSRGRDDWPDRVRPRQDYRDYRPPPRDRGYSPAREGPTVKRMRGDTWGDEGRHRFGAHDGYGMYGYAHDHFGMHPTVGPYGHQHATHQREPVVSGDMQTQPCMMTLKQFLATQDDSISDSDAITKYNEYKLEFRRQQMNEFFVAHKDEEWFKIKYHPEESQKRKEEQLSFLKRRCEVFLELLKSKEIGKVSVDASNTDALLRLLDTVVIKLEGGTEEDLKVLDIKPSVVEAAARTPATLNEEKVKTESKVDATAKELAVKMEEDSSKQETETDVLSVPQSEEDARNGNSKIKEELSKSMDDGNENGDKSKSNDAQKSEKEIAEVEHEAHKHESEDRKKRSRSDSGSSSSSSSSSSSSESEEEKDERMNKEDNEDEENMRIPEEEKKSDSADTMDNINRDKEVDEGKPVCDAEDLNTADDRDDNADQNKEQNEFEETTKDKNSSDPVNDENKENSDKKSQQEGDSKAETIDLAKDPADGGSRALHRTSSIFLRNLAPSITKAEVEAMCRRYNGFLRVAIADPLLERRWFRRGWVTFKREVNIKEICWNLNNIRLRDCELGAIVNKDLSRRVRPVNGITCHKTVVRSDIKLGAKIAHNLDDKWGLWKETPTAASGTGEAGDKNGSEVQPEESFGLQSKNPVLQNITDYLIEEASAEEEELLGLSEDSKKVSEGELIERDPQLIEVLDRLILYLRIVHSVDFYNHCEYPYEDEMPNRCGIIHARGPPSQSKVMSNEIQEYIRTFEGKMASFLTRMVDIDETDMKKLGAKDAEAEVEKFITANTQELAKDKWLCPLSGKKFKGPDFVRKHIFNKHAEKVEEVRKEVEYFNNYLKDSKRPQLPEHPGNAKKPGSEGATSATANASVGAGGYRNQPFGMSHSYAPMYASYAAASMMAPNPRGRAGFGRGGRMGGPDYRPVIHYRDLDAPREPDEFL
What is the function of this protein?
Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi).  Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex (By similarity).
What are the official names of this protein?
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the ARS2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COBS_SULIL
Sequence: MRLKGVLALFSFFTAIPIKSNASLEEIAEYSYISPLIIGISLALIESAVYVLLYRILEALAGIVLLGVVELLRGFNHLDGLLDLGDALMIKGDRERKIKALKDVEIGSGGIGLLLVYLSIQIVALLKLGFSFYTIFHLISSNVLSMTIGLYILSTISPIPESNLGKIFHNKLKGKSTVLLLELIPFISLYNIIVFLVFYMIMHKICRSLGGSSGDIAGASITLSFPLFLLTNEITNLNYSLLSILCYLFLHLH
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNPA_XANAC
Sequence: MNASNPCRRFPRSARVRTRAQYTIVFDTARRTSDPLLSLHWRTGDTPPRLGMAVSRKVDTRAVGRNRIKRVLRDAMRHLLPELAGGDYVIVARSAAAKATNPQIRDAFLRLLHRAGALPLPAAAGTMPPARTVHPSSLSPTEPEL
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RR19_JASNU
Sequence: MARSLKKNPFVVHHLVRKIDKLNKKKKKGIIKTWSRASTIIPTMIGHTIAVYKGKEHLPIYITDYMTGHKLGEFAPTLYFLRGHPTERPTKNDNRSQR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CYSQ_ECO57
Sequence: MLDQVCQLARNAGDAIMQVYDGAKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRESFLNPGFRVSIY
What is the function of this protein?
Converts adenosine-3',5'-bisphosphate (PAP) to AMP.
What are the official names of this protein?
3'(2'),5'-bisphosphate nucleotidase CysQ, 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase, 3'-phosphoadenosine 5'-phosphate phosphatase, PAP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily. CysQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: WTX1A_NEOIV
Sequence: FIGAALGALTAIPSIIKLFK
What is the function of this protein?
Has activity against Gram-positive bacteria.  Has insecticidal and hemolytic activities.
What are the official names of this protein?
U1-poneritoxin-Ni1a, U1-PONTX-Ni1a, Poneratoxin, Ponericin Pi II1.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Medium-length antimicrobial peptide (group 3) family. Ponericin-W subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: BIOB_PSYWF
Sequence: MSFLATLKEPGTSVCLKNEPAQSPSLHDHAPSTAAISREYIANLFDMPFMDLLLKAQGVHRQHFTANAVQISTLLSIKTGNCPEDCGYCSQSGHHRDTTGLQAEKRLEIDKVIAAAKRAKASGSSRFCMGAAWKHPSAKDMPYVAELIKEVKALGLETCMTLGMLTAEQSEQLAEAGLDYYNHNLDTSRRYYDEVVSTRSYDERLQTINHVRKSGINVCSGSIVGMGESREDRIDWVLELASMPLPPESIPVNLLVPIQGTPLGDKVLSEGQLPVLEWIRTIAVTRICCPSSYVRLSAGRESLSDAEQALAFMAGANSFFYGDKLLTTGNASQSNDDRMMQMLGLIPEAPKPKLTVIDALSGHQSQL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: CSA3_METJA
Sequence: MVRYMRYIATFGYHTNHIFDKNGKIIGIDDEKISNMILIYSLDVDADENTVNSIKNTKNYIESKLKEYNIPYLFVEVNPYEFNTNVKNFRKYIVPKTIINLTGGKRIVGYALFYAAVLEKENVEKVFYVSKLGDIIEFPLIPPDIKLTELEMKILNLLDKEGEMSVSNIAHKLERSLSTISEYVSQLEKKGLVKKLSKGRRKIVKKVI
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
What are the official names of this protein?
CRISPR locus-related putative DNA-binding protein Csa3.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csa3 family.
Protein: THYX_MYCSK
Sequence: MAETAPLRVQLIARTEFTVPPDVPWETDAEGGAALVEFAGRACYQSWSKPNPRTATNASYLRHIIDVGHLSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSQVVVPPGIEGDAELEGLFTAAADASRAAYAELLAKLEAKLMGDEPREGRATLRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIACLRELVAVAPAVFADFEIYPLADGTEVATTPLVTEA
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: PCGF2_HUMAN
Sequence: MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGPLENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTASGATTAANGGSLNCLQTPSSTSRGRKMTVNGAPVPPLT
What is the function of this protein?
Transcriptional repressor.  Binds specifically to the DNA sequence 5'-GACTNGACT-3'.  Has tumor suppressor activity.  May play a role in control of cell proliferation and/or neural cell development.  Regulates proliferation of early T progenitor cells by maintaining expression of HES1.  Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity).  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332).  Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
What are the official names of this protein?
Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDTG_ECOUT
Sequence: MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQISN
What is the function of this protein?
Confers resistance to fosfomycin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtG.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYSG1_PECAS
Sequence: MNYLPIFADLRQRPVLVVGGGEVATRKIDLLQRAGAEVKIVALALAEPLAAQHQAGQVEWLAQSFTPELLSGVFLVIAATDDAELNAAVFEAANQRHLLVNVVDDQPKCTFIFPSIVDRSPLVVAISSGGQAPVLARLLREKLESLLPASLGTMAEIAGSWRDRIKTRLHSMPARRRFWERLFVGRFASLVSAGQLEQAEGELQQQLVNQQDEQQLPAAARGEVALVGAGPGDAGLLTLRGLQVMQQADVVLYDHLVSADVLDLVRRDAERICVGKRASTHSLPQGEINQLLVKLAQEGKRVVRLKGGDPFIFGRGGEELQAVAQAGITFQVVPGVTAAAGVTAYAGIPLTHRDHAQSVIFITGHCRPDGDSLDWSTLARGRQTLAIYMGTMKAAEISQQLIAHGRSAQTPVAVISRGTRHDQQVQIGTLQELEHLARQAPTPALLVIGEVVDLHHQIAWFGQTTPTVPQDSRPAVVNLA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: RNASO_LITCT
Sequence: MCAKSLLLVFGILLGLSHLSLSQNWATFQQKHIINTPIINCNTIMDNNIYIVGGQCKRVNTFIISSATTVKAICTGVINMNVLSTTRFQLNTCTRTSITPRPCPYSSRTETNYICVKCENQYPVHFAGIGRCP
What is the function of this protein?
Preferentially cleaves single-stranded RNA at pyrimidine residues with a 3'flanking guanine.  Hydrolyzes poly(U) and poly(C) as substrates, and prefers the former.  The S-lectins in frog eggs may be involved in the fertilization and development of the frog embryo.  This lectin agglutinates various animal cells, including normal lymphocytes, erythrocytes, and fibroblasts of animal and human origin.  It is cytotoxic against several tumor cells.
What are the official names of this protein?
Oocytes ribonuclease, RC-RNase, Sialic acid-binding lectin, SBL-C.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: TATD1_BOVIN
Sequence: MSRFKFVDIGINLTDPMFRGIYRGVQKHQDDLQDVIERAVQIGVKKFMITGGNLQDSKDALHLAQTNDMFFSTVGCHPTRCDEFEKNDPDHYLMELLNLAESNKGKVVAIGECGLDFDRLQFCSKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMRRNRDRCVGGVVHSFDGTKEAAAALMDLGLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKNTHAGSKYIKTSFPTKKKWENGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKIFFPDM
What is the function of this protein?
Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules (By similarity).  Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity).
What are the official names of this protein?
Deoxyribonuclease TATDN1.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IT2_PSOTE
Sequence: QELVDVEGKTVRNGGTYYLVPQLRPGGGGMEAAKVGNEDCPLTVVKSLDENSNGEPIRIASRLRSTFIPEYSLVNLGFADPPKCAPSPFWTVVKDQSERLPSIKLGEYKDSELDYPFKFERVYAASKMYAYKLLYCGSEDEEEEMMCKDIGVYRDQEGYQRLVVSKHNPLVVGFKKAESSTT
What are the official names of this protein?
Trypsin inhibitor 2, WTI-2.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I3 (leguminous Kunitz-type inhibitor) family.