PharMolix/UniProtQA huggingface dataset:
Protein: HSLV_CERSK
Sequence: MAEERFPGWHGTTILAVRRGGEVVVAGDGQVSLGQTVIKGTARKVRRLSPGGHEVVAGFAGSTADAFTLLERLEKKLEAAPGQLARACVELAKDWRMDKYLRNLEAMLIVTDGETLLVLTGAGDVLEPEHDVTAIGSGGNFALAAARGLMATELPAEEIARKAMAIAADICVYTNGNLTVERISK
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG17_BOTFB
Sequence: MASSPNAPGSHSHTSISTVNPPPPAHTNQGLEIPLETLVSHLLASKRSLSSISTVWRANEIVTSAKNALEESAILQAKTRFLQSGINEQMKTLLKVRKTVEFVYNDGQEDFSNVLHNLDAADARLESTMNMLRSTMVDAAFRPAGEEPRNLLDFVDEQGVEKMRDGLKELIDESKEAEAAFGTSILSFDSDIRSLKSGFKNSKRKTSSYSPIPNHLYTLEGHAQEMASLLSSLSSHFDLCLNAIRHTEGGYAAVRNAASNPPPGAEPVSVSGVMSNSHDDINEAPLTEHEREEMFSILEKDAAEVEDVVMELHDRQNEMEAKHDAILDHVSHLAEQFRHTASVYKTLEGVYQRLPRYILAGHDFRARWEDTKVHINEQMNELEGMRLFYENYLSSYDGLILEVHRRTVAEEKARSIAKKAMEQINKIYDIDVKERNDFKFDVGDYLPVDLYPGISEAPPKWDFRLVEDEEGGSSTPLLERSVVKESFKRDRERHRNSKDN
What is the function of this protein?
Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation.  Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles.  Plays particularly a role in pexophagy and nucleophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 17.
What is the protein family that this protein belongs to?
Belongs to the ATG17 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: MNX1_MOUSE
Sequence: MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLATTVSGPGRGGSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGASTFQLDQWLRASTAGMILPKMPDFSCEAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGTGKGGSEEKTEEELMGPPVSGDKASGRRLRDLRDSDPDEDEDDEEEDNFPYSNGAGAHAASSDCSSEDDSPPPRLGGPGHQPLPQ
What is the function of this protein?
Transcription factor (PubMed:18539116).  Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (PubMed:18539116).  Plays a role in establishing motor neuron identity, in concert with LIM domain transcription cofactor LMO4 (PubMed:18539116).  Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking interactions of ISL1-LHX3 complexes with regulatory elements (PubMed:18539116).  Involved in pancreas development and function; may play a role in pancreatic cell fate specification (PubMed:10471502).
What are the official names of this protein?
Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRS6B_CAEEL
Sequence: MSAAALEEIGIAPLQENTSLRPPPLPATCVDVSSDDYIKLTTLERQLAHLQVMEDYIKLETRNLEKELLHAQEEVKRIQSVPLVIGQFLEAVDQNHAIVGSTTGSNYYVRVLSILDRELLKPGCSVALHKYSNALVDVLPPEADSSIQMLRPDEKPDISYGDIGGLDMQKQEVREAVELPLTHGELYQQIGIDPPRGVLMYGPPGCGKTMLAKAVAANTAASFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENSPSIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQSTNVKVIMATNRQDTLDPALLRPGRLDRKIEFPLPDRRQKRLVFSTVCSRMNLSDDVDLEDWVARPDKISGADINSICQEAGMQAVRENRYVVLTKDLEKAYKNVVKKDTNDFEFYK
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
What are the official names of this protein?
Probable 26S proteasome regulatory subunit 6B.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LCTP_STRIN
Sequence: MFQAILAIIPILWLILSLAVFRMRGDLACFIGLIITLLTSIIGFHFSIKDGLTAGLEGAMMGFWPIIYIIVAAVFTYNLTTASGGMTVIKRLLMTITEDKRILVLILAWGFGGFLEAIAGFGTAVAIPASILVALGMKPLRAALICLIANTTPTAFGAIGLPVTTLAQVTGLEVKQLSVIVSLQLFILIVAIPFVLVSLTGEGKRPIKGVFGITLASGLAFALPQILVSNYVGAELPSIIGSLFCILVTILFVNLRERGKNASPVGGDVAFKEGIIRCLPFILVFFFIMLTSSLFPAINQLLAKVSTTVSIYTGEHAKPYTIKWLTSPGTMIILATFIAGLIQGMSFKEIGSILAKVLNKLTKTMVTVASIVALSKVMSYSGMINTIAVSLVAVTGGFYPFIAPVIGTLGTFITGSDTSANVLFGELQVKAANNLNMNPYWMAAQYDRGNCRKNDFASKHCSCSGTYWFRRSRR
What is the function of this protein?
Plays a role in L-lactate utilization.
What are the official names of this protein?
L-lactate permease.
What is the protein family that this protein belongs to?
Belongs to the lactate permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISCS_SALNS
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFLTLDGTFGNPASRSHRFGWQAEEAVDIARNQIAELVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLNELEAAMRDDTILVSIMHVNNEIGVVQDIATIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRIRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMETEMARLRGLRNRLWNGIKDIEEVYLNGDLEQGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGMNDELAHSSIRFSLGRFTTEEEIDYTIDLVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DP60R_ASFB7
Sequence: MSSIWPPQKKVFTVGFITGGVTPVMVSFVWPAAQPQKKINYSRKKKYFRPRSFYKKNVSF
What are the official names of this protein?
Uncharacterized protein DP60R.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: NU1C_TRIEI
Sequence: MNSGIDLQRTFIQALVDLGLSSEIAKTLWLPFPMLLMIVVATVGVLVTVWLERKISAAAQQRIGPEFMGPLGTLAPLADGLKLLFKEDVVPAKADPLLFTLGPVIVAVPVFLSYLVVPFGQNLVITDLGVAIFLWIALSSIQPIGLLMSGYASNNKYSLLGGLRAAAQSISYEIPLALAVLAVAMMSNSLSTIDIVEQQSSYGILGWNIWRQPLGFIIFWIAVLAECERLPFDLPEAEEELVAGYQTEYTGMKFALYYLASYVNLVLSSLLVAVLYLGGWESPLPVELISNWFGVSETTPWLQITNATLGIIMTLLKTYLLVFIAVLLRWTLPRVRIDQLLDLGWKFLLPVALVNLLLTAALKLTFPFAFGG
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, NAD(P)H dehydrogenase I subunit 1, NDH-1 subunit 1, NDH-A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: XPR1_XENTR
Sequence: MKFAEHLSAHITPEWRKQYIQYEAFKEMLYAAQDQAPSIEVTDEDTVKRYYAKFEEIFFQTCEKELAKINTFYSEKLAEAQRRSATLQNELQSSLDAQRESSAIPGLRQRRKAVFALTHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETETVVTNELESGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLYCGIFIVLNMAIIMAGSHYLLGKDVWPMVRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGILWCFSLFSCIFGLWINLQMHLNPLILYGLMLLFLVNPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLAVILMDLEFMICFYSFELKWGDSDGLVNSANSVCNSYSYGVRAVVQCIPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERNHSDAQVFFYLWIIFYLISSCYTLIWDLKMDWGLFDRNAGENTFLREEIVYPQKAYYYCAIIQDVILRFAWTIQISVTSLNLFTDAGDIISTVLAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQDDGVKNRVKSRIWKRSQSMSLRRPRLSSQSKMKDAKILIDDTDDEANT
What is the function of this protein?
Plays a role in phosphate homeostasis.  Mediates phosphate export from the cell.  Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.
What are the official names of this protein?
Xenotropic and polytropic retrovirus receptor 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SYG1 (TC 2.A.94) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SLYA_SALPA
Sequence: MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEDKGLISRQTCASDRRAKRIKLTEKAEPLIAEMEEVIHKTRGEILAGISSEEIELLIKLVAKLEHNIMELHSHD
What is the function of this protein?
Transcription regulator that can specifically activate or repress expression of target genes.
What are the official names of this protein?
Transcriptional regulator SlyA.
What is the protein family that this protein belongs to?
Belongs to the SlyA family.
Protein: COAW_BACC2
Sequence: MERTIGIDAGGTLTKIAYFNEKRLLTFEKFYSHEQHKIIDWIKNNNGIKQICITGGKSKLLQQLLTGSYKIIELNEFEATLAGVQYILKEEKHAIRNFILTNIGTGTSIHYVYNEQYIRAGGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKELDITVGDIYGGILSPIDNNLTASNFGKAAITESNNSSSDILATVQGLVGEVVTALSLQFAETKNIEHIIYIGSTLCNNVQLQHIISSYTEYQNKTPIFLQDGGNSGAIGALLHATK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type II pantothenate kinase, PanK-II, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type II pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCM8_BOVIN
Sequence: MNGKYRGRGFGQGRFQSWKSGRGGRGFSGKWREREHRPDLNKATGKHPEQTPQSLLLQSTLDHFIPYKGWKLYFSEVYSDSIPFIEKIEAFESFFTERIELYDKDEIERKGSILVDFKELINDDEIIKLIPNIANELRDTPEKTLACMGLAIHQVLTKDLERHAAELQAQEGLSRNGETVVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNTKPLCTKMAFLCAACGEIQSLSLPDGKYNLPTKCPVPACRGKSFTALRSSPLTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGVVKVSNAEEANSVSNNKGQKTKASEDGCKHGALMEFSLKDLYAIQEIQSEENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYADDKNRIPIRGDPHVLVVGDPGLGKSQMLQAVCSVAPRGVYVCGNTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSISLAKAGMVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVIAIRAGKQRAVSSATVARMNSQDSNTSILEVVSDKPLSERLKVVPGETIDPIPHQLLRKYIGYSRQYVYPRLSTEAAQILQNFYLELRKQSQRLSSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSAAKRFISALNKIAERTYNNLFQFHQLQQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM
What is the function of this protein?
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR).  Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity.  Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs.  The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression.  However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC).  Probably by regulating HR, plays a key role during gametogenesis.  Stabilizes MCM9 protein.
What are the official names of this protein?
DNA helicase MCM8, Minichromosome maintenance 8.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to nuclear foci. Localizes to double-stranded DNA breaks. Binds chromatin throughout the cell cycle.
Protein: RL35_TROW8
Sequence: MVPKQKTHSGAKKRFKLTGSGSVSRARAGMRHNFEHRSSRVTRRLTGRQFVSDADSKLARKLLGK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: TED1_YEAST
Sequence: MLRCAVKKFAYFATFLTIVANIYIYTYPSFHPEQCSWNCSNKNAPLQKDLTFVDKVKNYFSDVREQWHGSHASAGNDEDIHILAFGDPQIKGIWPKTPYVSRLDTYGNDYYLGHIYDMMQQRLKPQVVTVMGDLFSSQWIGDSEFHNRTKRYISRIFKRDPTSIENIKQQNLDEKGQYKANWPEWGDRFNEILDNVKENEADNQELSFGFGYENIHSWNPDLEDFLIINITGNHDVGYSGDATYQHMTRFHDLFGKDNYWIEYETNTTHPWRIVVLNDLLLEGPALQPEFVEATWIFLNQLNERKFNGSTVLLTHVPFYKREGLCVDGPDTRYYPDAHAPESYKSGLLRSQNHLSESVSNQVLNMIFENGKPGIILTGHDHEGCETVYNKKSTSTWEATKNIESDVFVKEITVKSMMGEFNGNTGLVTGHFNTDSMTWEWTFSLCPFAIQHVWWFAKVSLLVTIFTWSSLLFV
What is the function of this protein?
Acts together with EMP24 and ERV25 in cargo exit from the endoplasmic reticulum.
What are the official names of this protein?
Protein TED1, Trafficking of EMP24/ERV25-dependent cargo disrupted protein 1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: UREF_NITOC
Sequence: MNSLWPLLRLASPQLPIGAYTYSQGLESAIDQGIVWDADSVRLWLSDQLAMNIACFEAPLFARMLEAAAQGQWQQLFYWAEEYVASRETRELYQESRQMGFSLVQLLNDLPELDEAMRHQLLGFVEPPLPLVWAVAARTWNLDTRSAVAAWLWGWLENQLAALMKALPLGQQAAQRLLSQLLPELDEALETALACSDEQLANGTLGLSIASMIHETQYTRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_STREM
Sequence: MANAIIETAKERFTQSHHSLAREYASIRAGRANASLLDRIQVDYYGAPTPLNQLASITVPEARVLLISPFDKSSIKDIERALNASDLGITPANDGSVIRLVIPALTEETRKELAKEVKKVGETAKVSIRNIRRDAMDEAKKQEKAKEITEDELKALEKDIQKATDEAVKEIDRMTADKEKELLSV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_CHLPN
Sequence: MKNSFGSLFSFTTWGESHGPSIGVVIDGCPAGLELHESDFVPAMKRRRPGNPGTSSRKENDIVQILSGVYKGKTTGTPLSLQILNTDVDSSPYENSERLYRPGHSQYTYEKKFGIVDPNGGGRSSARETACRVAAGVVAEKFLANQNIFTLAYLSSLGSLTLPHYLKISPELIHKIHTSPFYSPLPNEKIQEILTSLHDDSDSLGGVISFITSPIHDFLGEPLFGKVHALLASALMSIPAAKGFEIGKGFASAQMRGSQYTDPFVMEGENITLKSNNCGGTLGGITIGVPIEGRIAFKPTSSIKRPCATVTKTKKETTYRTPQTGRHDPCVAIRAVPVVEAMINLVLADLVLYQRCSKL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: DEF1_HUMAN
Sequence: MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMACYCRIPACIAGERRYGTCIYQGRLWAFCC
What is the function of this protein?
Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs (PubMed:15616305, PubMed:17142766, PubMed:20220136, PubMed:24236072).  Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis (PubMed:20214904).  Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry (PubMed:18191790).  In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release (PubMed:35080426).  Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs (PubMed:27031443).
What are the official names of this protein?
Neutrophil defensin 1, Defensin, alpha 1, HNP-1, HP-1, HP1.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBIA_VIBVU
Sequence: MSVEKAKAYWQLMRMDRPIGTLLLLWPTLWALIIAAEGTPDWHVLLVFVLGVVLMRSAGCVINDFADRKVDGHVKRTQQRPLPSGRVTAKEAIILFLLLGISSFLLVLTMNPLTIQLSFAGIVLAFIYPFMKRYTHLPQLFLGLAFSWAIPMAWAAQANELPWVVWFVFAINALWTIAYDTQYAMVDRDDDVHIGVKSTAILFGRHDKLIIGLLQLLTLVMLVWLGLHYQLGQSFYWSVLAAGALFVYQQHLIRHRQRELCFQAFLNNNYVGMVLALGLFVAFW
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IRAK3_MOUSE
Sequence: MAGRCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGKSGTRELLWSWAQKNKTIGDLLEVLQDMGHQRAIHLIINYGVSWTPSVQTHHELPFPSFPPEVKHACRENDPGPLEPANVTVDNVLVPEHNEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELMEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNHSVPPKEVLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSSSHEECWSPELVAPSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ
What is the function of this protein?
Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:12150927, PubMed:12054681, PubMed:29686383).  Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (PubMed:12150927, PubMed:12054681).  Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383).
What are the official names of this protein?
Interleukin-1 receptor-associated kinase 3, IRAK-3, IL-1 receptor-associated kinase M, IRAK-M, Inactive IL-1 receptor-associated kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation.
Protein: Y2098_STAAN
Sequence: MEKVYVAGAIPEVGLKLLQEHFEVEMYEGKGLVDKDTLIKGVKNATALISLLSTNVDKDVIDAGKDLKIIANYGAGFNNIDIEYAREKSIDVTNTPKASTNATADLTIGLVLAVARRIVEGDQLSRTTGFDGWAPLFFRGREVSGKTIGIIGLGEIGSAVARRARAFDMDVLYTGPNRKEEKEREIGAKYVDLDTLLKNADFITINAAYNPKMHHLIDTEQFKMMKSTVYLINASRGPIVHEQALVQALKDNEIEGAALDVYEFEPDITDDLKSLNNVVLTPHIGNATFEARDMMSKIVANAAISAVQGEKPQFVVN
What are the official names of this protein?
Putative 2-hydroxyacid dehydrogenase SA2098.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Protein: HV118_HUMAN
Sequence: MDWTWSILFLVAAATGAHSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYGISWVRQAPGQGLEWMGWISAYNGNTNYAQKLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 1-18.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: SEC23_KLULA
Sequence: MDFEQNEDINGVRFSWNVFPASRTDANKNVVPVGCLYTPLKEREDLAVAGYNPVVCGNINCKSVLNPYCEIDVRSNTWTCPICKTRNILPQHYANMTQETLPLELTNTTVEYITSVPVQVPPIFFFIVDTTAEEENLQALKESIITSLSLLPANALVGLITYDNVIQLHDLSSASIDKCNVFRGDREYQLAQLVEMLTGEKLNAAQAVNINAPTKVTPFSLNRFFLPLEQVEFKLTQLLENLKPDQWDVKSGFRPLRATGSALNIASLVLEGCYKNVAARIILFSSGPGTVGPGLVVSPELKDPLRSHHDIDSDSAKHYKKACKFYNQLAQKVADNGHTVDIFAGCYDQVGMSEMKRLTDSTGGVLLLTDAFSTAIFKQSYLRFFSKDEEGYLQMAFKGTLSVKTSSDLKLQGLIGHASAVKTKTEASNVSDSEIGIGGTSSWKMSSLSPRHTYAVFFEIVNPGASAEVMTDRPKLAYTQFITSYEHSSGTNRVRVTTVANQMLSFGNPAIASSFDQEAAAVLMARIAVDKAESDDGADVIRWIDRTLIKLCQKYADYNKNDPSSFRLSPQFSLYPQFTYYLRRSQFLSVFNNSPDETAFYRHIFTREDTTNSLIMIQPTLTSFSMEEEPQPVLLDSVSVKPNTILLLDTFFYILIYHGEQIAQWRKAGYQDDPQYADFKSLLEEPKLEAAELLIDRFPLPRFIDTEAGGSQARFLLSKLNPSDSYQSGAVAGSTIVLTDDVSLQNFMSHLQQVTVNGQT
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC23.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.