PharMolix/UniProtQA huggingface dataset:
Protein: Y7I5_ENCCU
Sequence: MMRTWMVYVVGLVGELYGSQVEETREMREMKEALERLFSRRLSDSEIEMVESLEDGGNFETRVLVPVIFHKDKVVVSPAARYRDIEKEERVYVEEVIRRLRSLVWHSMVYIYVPKNNDWIMDLICEVLEMSSPQRLDDVALYKDTGGKCGMKFVDLVNKMFKQNADMLIKFGDLLSNGAETRILELPDSLREDERRREVEMLQRVKEYGKMLCTEDKQKEIVEAQKIMCDACEQIWRREEDRKEFTMEIYSRYLNMKVMRGGVERDVEDPLIDHMDHYMLISTHKKYKCMDVVAELVRKVFVEDKDIEDSDVMSAVCSVRERKRLEEMREMEERKRKEEERAKNEEELLRMVEREEREKREESKGRGKKKRGNRGAGESKEESKGRGKRKRGNKGAGESKEEDRGEEGGVEAEDPLEEMAVGEAWRKKKGSGEKRISEEHHYKVHSRVLRWKKDAGEIKRELDEGYEKKWKNRSIEEIKEQKKVHDIVEVMKLLRDKEKCDRFFVRTGKYMKGKSERWKMVANGILEEGGEKKVGKVEVGLFKGEGGESVVYHLMFRPTETERTGRVGGSSFGKYDDVDEIKKEKSSDMFGFRYPSGVRCEMTSNRNEFRIEYRNRKNTSEVLRTLTILRIPET
What are the official names of this protein?
UPF0329 protein ECU07_1850/ECU10_0050.
What is the protein family that this protein belongs to?
Belongs to the UPF0329 family.
Protein: THER_BACSO
Sequence: MDKRAMLGAIGLAFGLMAWPFGASAKEKSMVWNEQWKTPSFVSGSLLKGEDAPEELVYRYLDQEKNTFQLGGQARERLSLIGKQTDELGHTVMRFEQRYRGIPVYGAVLVAHVNDGELSSLSGTLIPNLDKRTLKTEAAISIQQAEMIAKQDVADAVTKERPAAEEGKPTRLVIYPDGETPRLAYEVNVRFLTPVPGNWIYMIDAADGKVLNKWNQMDEAKPGGGQPVAGTSTVGVGRGVLGDQKYINTTYSSYYGYYYLQDNTRGSGIFTYDGRNRTVLPGSLWADVDNQFFASYDAAAVDAHYYAGVVYDYYKNVHGRLSYDGSNAAIRSTVHYGRGYNNAFWNGSQMVYGDGDGQTFLPFSGGIDVVGHELTHAVTDYTAGLVYQNESGAINEAMSDIFGTLVEFYANRNPDWEIGEDIYTPGIAGDALRSMSDPAKYGDPDHYSKRYTGTQDNGGVHTNSGIINKAAYLLSQGGVHYGVSVTGIGRDKMGKIFYRALVYYLTPTSNFSQLRAACVQAAADLYGSTSQEVNSVKQAFNAVGVY
What is the function of this protein?
Extracellular zinc metalloprotease.  Has collagenase activity.
What are the official names of this protein?
Thermolysin, Thermostable neutral proteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M4 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBY_SYNE7
Sequence: MDWRLIVVLAPILLAGGWAVFNIGKAALEQINRALKGDQA
What is the function of this protein?
Manganese-binding polypeptide with L-arginine metabolizing enzyme activity.  Component of the core of photosystem II.
What are the official names of this protein?
Photosystem II protein Y.
What is the protein family that this protein belongs to?
Belongs to the PsbY family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: SSRP_FUSNN
Sequence: MIIANNKKAFFDYFIEEKYEAGIELKGSEVKSIKAGKVSIKEAFVRIINDEIFIMGMSVVPWEFGSVYNPEERRVRKLLLHRKEIKKIHEKVKIKGYTIVPLDVHLSKGYVKMQIAIAKGKKTYDKRESIAKKDQERNLKREFKNNNR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MRAY_CORDI
Sequence: MTQIIIAGAVGLLVSIFVTPVLIRRFSAEGLGQEIREDGPKSHLRKRGTPTMGGIAILIGITVAYAVTGIVGQVTGTGGLTASGLLVLGLTLALGGLGFADDFIKLYMGRNLGLNKKAKLIGQLAISLIFGALILLFPNADGLTPGSSHLSFLRDLPTVDLAIGPKAVGIAIFLLFIYILISAWSNAVNLTDGLDGLAAGSTAIVMGTYTVITFWQFRNSCSAGAQPGCYDVRDPLDLAILAAAGLGACLGFLWWNAAPAKIFMGDTGSLALGGLVAGLSVASRTELLMIIVGALFVLEAASVVIQVAGYRTKKIRIFRMAPFHHHFENGGWAETTVVIRFWLIAAVAALIGASIFYGEWLSLTGV
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LOC1_COCIM
Sequence: MAPNRGASSSKQSNKSASKKSSSSSTLASKSRVSKSSANKNAKRPPPKEVKTKARTEKALQKKTKKREYTEKELNLPALNMITPVGVQKPRGKKKGKVFVDDQESMMTILAMVNAEKEGQIESKIMKARQMEEIREARRKEAEARQEQRKFKYEETKELLKRKRKNGGKEQQAKKDNDQSTTPPKKPNKKRVAFA
What is the function of this protein?
Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
What are the official names of this protein?
60S ribosomal subunit assembly/export protein LOC1.
What is the protein family that this protein belongs to?
Belongs to the LOC1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MTEF3_RAT
Sequence: MALLAQQLSRWFNSVKLSSFIKATQVTKHSAGLGKNASAQALLSSDTCFLQWGIKTDRALFSWSSFQSANTTRRKSSTNSTLLPSVSEQPEKIPRLESELPLEELDDLPPLSPLQPVSEEEAIQIAAYSPLPLSSSTLADYVDHSETLQKLVQLGVDLSKIEKHPDVANLLLRLNFEKDIKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDLENLKTRVAYLQSKNFSKTDIACMVKNAPFLLSFSVERLDNRLGFFQKELELSVKKTRDLVVRLPRLLTGSLEPVKENMKVYRLELGFKHNEIQHMVTKIPKMLTANKRKLTETFDYVHNVMNIPHHIIVKFPQVFNTRVFKIKERHLFLAYLGKAQYDPAKPNYVSLDKFVSFPDEVFCKEIAKASVNDFEKFLKTL
What is the function of this protein?
Binds promoter DNA and regulates initiation of transcription.  Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes.  Required for normal mitochondrial function.  Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).
What are the official names of this protein?
Transcription termination factor 3, mitochondrial, Mitochondrial transcription termination factor 3, mTERF3, mTERF domain-containing protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the mTERF family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYT_MYCLB
Sequence: MSAPVHPVPGADGGDPLRPATPGLRSPQVPIQVPAGSTAAAAVSEAGLPTHGAPDAIVVVRDADGKLRDLSWVPDVDVEVTPVPVNTDDGRSVIRHSTAHVLAQAVQDLFPQAKLGIGPPITDGFYYDFDVAEPFTPEDLKALEKRMRQIVKEGQLFSRRIYESKEQARTEWAGEPYKLELVDDESGDAEIMEVGGDELTAYDNLNARNGERIWGDLCRGPHIPTTKHIPAFKLTRSSAAYWRGNQKNASLQRIYGTAWESQEALDRHLEMITEAQRRDHRKLGIELDLFSFPDEIGSGLAIFHPKGSIVRREMEEYSRRKHIEAGYQFVNTPHITKAQLFHTSGHLDWYAEGIFPPMHLDAEHNDDGTVRKPGQDYYLKPMNCPMHTLIFSSRGRSYRELPLRLFEFGTIYRYEKSGVVHGLTRARGFTMDDSHIFCTREQLHCELASLLRFVLDLLGDYGLEDFYLELSTKDPEKFVGSEEIWEEATAALAEVAENSTLPLVPDPGGAAFYGPKISVQVRDALGRSWQMSTIQVDFNFPERFALEYTSADGTRQRPVMIHRALFGSIERFFGILTEHYAGAFPAWLAPIQVVGIPVTGEHVSYLEEVAAQLKSCGVRTEVDVSDDRMAKKIVRHTNQKVPFMLLAGDRDVRTGSVSFRFGDRTQINGVARDSAVEAIVCWIVDRENDFPTAELVKVTGGE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERBIN_MOUSE
Sequence: MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLSARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS
What is the function of this protein?
Acts as an adapter for the receptor ERBB2, in epithelia.  By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity).  Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728).
What are the official names of this protein?
Erbin, Densin-180-like protein, Erbb2-interacting protein, Protein LAP2.
What is the protein family that this protein belongs to?
Belongs to the LAP (LRR and PDZ) protein family.
What are the subcellular locations of this protein?
Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane (By similarity). Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Protein: HBB_TAMHU
Sequence: VHLSGEEKTALATLWGKNVADEVGGEALGRLLVVYPWTQRFFDSFGDLSSASALMSNAKVKAHGKKVLDSFSEGLKHLDDLKGTFSSLSELHCDKLHVDPENFRLLGNMLVLVMAHHLGKDFTPAAQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: SP2AB_GEOKA
Sequence: MRNEMHLQFSARSENESFARVTVAAFVAQLDPTMDELTEIKTVVSEAVTNAIIHGYNNDPNGIVSISVIIEDGVVHLTVRDEGVGIPDIEEARQPLFTTKPELERSGMGFTIMENFMDEVIVESEVNKGTTVYLKKHIAKSKALCN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: ASB15_HUMAN
Sequence: MDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVWSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKLT
What is the function of this protein?
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
Ankyrin repeat and SOCS box protein 15, ASB-15.
What is the protein family that this protein belongs to?
Belongs to the ankyrin SOCS box (ASB) family.
Protein: COI2_ORYSJ
Sequence: MGGEAGERRLGRAMSFGIPDVALGLVMGFVEDPWDRDAISLVCRHWCRVDALSRKHVTVAMAYSTTPDRLFRRFPCLESLKLKAKPRAAMFNLIPEDWGGSASPWIRQLSASFHFLKALHLRRMIVSDDDLDVLVRAKAHMLSSFKLDRCSGFSTSSLALVARTCKKLETLFLEDSIIAEKENDEWIRELATNNSVLETLNFFLTDLRASPAYLTLLVRNCRRLKVLKISECFMLDLVDLFRTAEILQDFAGGSFDDQGQVEESRNYENYYFPPSLLRLSLLYMGTKEMQVLFPYGAALKKLDLQFTFLSTEDHCQLVQRCPNLEILEVRDVIGDRGLEVVAQTCKKLQRLRVERGDDDQGGLEDEHGMVTQVGLMAVAQGCPHLEYWAVHVTDITNAALEAIGTYSSSLNDFRLVLLDREANITESPLDNGVRALLRGCTKLRRFAFYVRPGALSDVGLGYIGEFSKTIRYMLLGNVGESDQGLLQLSTGCPSLQKLELRGCFFSERALAVAVLQLKSLRYLWVQGYKASPNGTDLMAMVRPFWNIEIIAPNQDEVCPDGQAQILAYYSLAGMRSDYPHSVIPLYPSV
What is the function of this protein?
Involved in jasmonate (JA) signaling.  Required for jasmonate signaling in plant defense responses (By similarity).  Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including TIFY/JAZ family (By similarity).
What are the official names of this protein?
Coronatine-insensitive protein homolog 2, OsCOI2.
Protein: PHOL_MYCTU
Sequence: MTSRETRAADAAGARQADAQVRSSIDVPPDLVVGLLGSADENLRALERTLSADLHVRGNAVTLCGEPADVALAERVISELIAIVASGQSLTPEVVRHSVAMLVGTGNESPAEVLTLDILSRRGKTIRPKTLNQKRYVDAIDANTIVFGIGPAGTGKTYLAMAKAVHALQTKQVTRIILTRPAVEAGERLGFLPGTLSEKIDPYLRPLYDALYDMMDPELIPKLMSAGVIEVAPLAYMRGRTLNDAFIVLDEAQNTTAEQMKMFLTRLGFGSKVVVTGDVTQIDLPGGARSGLRAAVDILEDIDDIHIAELTSVDVVRHRLVSEIVDAYARYEEPGSGLNRAARRASGARGRR
What are the official names of this protein?
PhoH-like protein.
What is the protein family that this protein belongs to?
Belongs to the PhoH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE2_STRGG
Sequence: MIPGEILHGDGDIPLNAGRPVTRLTVLNAADRPVQVGSHYHFAEANPGLRFDRAAAHGLRLNIAAGTAVRFEPGIPADVELVPLTGRRVVPGLRGETGGALDA
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNJB1_BOVIN
Sequence: MGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEGLKGSGPSGGSSGGTNGTSFSYTFHGDPHAMFAEFFGGRNPFDNFFGQRNGEEGMDIDDPFSGFPMGMGGFTNMNFGRSRPAQEPTRKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKRGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGEGLPLPKTPEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI
What is the function of this protein?
Interacts with HSP70 and can stimulate its ATPase activity.  Stimulates the association between HSC70 and HIP.  Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response.  Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).
What are the official names of this protein?
DnaJ homolog subfamily B member 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
Protein: YIDC_SACD2
Sequence: MNWLRNSLIAAILVITYVLFIRWNEFSERQQVPTIANQPAAVTTPAYEAVPSDDAVASSATEESDVPEVSVSAEPVAAPKAVYQPKLVTVKTDVLEVQIDTNGGDVLQVVLLKHLADKADDNQPFVLMTQNSAHTYVARSGLAGGNGPDGAKKGRAKYSVAKTNYSLNSDDQVVVDLTLDQENAQITKRFTFTKSSYLIDVEYIITNRADTPWAAKLYGQIIRDGSEPSYGYMGMRPYLGAAITTPEVNYEKVSFDDMDDGPFKVEQKGGWVSLIQHYFISAWIPPKDATNSYELSKSSKGNYVLRFISETTTVAPHSVGTVKAGFYAGPKNIRRLEEISPHLDLTIDYSFLWFIAKPLFFALDFIHGLVGNWGVAIILLTVLIKAVFFYPSAMSYRSMAKMRKLQPMMAELKERYGEDKQKMSGELMKLYKKEKVNPFGGCLPILLQMPVFISLYWMIMESVELRHQPFFLWIQDLSVKDPLFILPLLMGVTMYIQQKLNPTPPDPMQAKVMQMMPIGFTFLFMFFPAGLVLYWVVNNTLSISQQYVITRNIEKAG
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: C85A1_SOLLC
Sequence: MAFFLIFLSSFFGLCIFCTALLRWNQVKYNQKNLPPGTMGWPLFGETTEFLKLGPSFMKNQRARYGSFFKSHILGCPTIVSMDSELNRYILVNEAKGLVPGYPQSMIDILGKCNIAAVNGSAHKYMRGALLSLISPTMIRDQLLPKIDEFMRSHLTNWDNKVIDIQEKTNKMAFLSSLKQIAGIESTSLAQEFMSEFFNLVLGTLSLPINLPNTNYHRGFQARKIIVNLLRTLIEERRASKEIQHDMLGYLMNEEATRFKLTDDEMIDLIITILYSGYETVSTTSMMAVKYLHDHPKVLEELRKEHMAIREKKKPEDPIDYNDYRSMRFTRAVILETSRLATIVNGVLRKTTQDMEINGYIIPKGWRIYVYTRELNYDPRLYPDPYSFNPWRWMDKSLEHQNSFLVFGGGTRQCPGKELGVAEISTFLHYFVTKYRWEEIGGDKLMKFPRVEAPNGLRIRVSAH
What is the function of this protein?
Catalyzes the C6-oxidation step in brassinosteroids biosynthesis (PubMed:15710611).  Converts 6-deoxocastasterone (6-deoxoCS) to castasterone (CS) (PubMed:15710611, PubMed:9990098).  May also convert 6-deoxoteasterone (6-deoxoTE) to teasterone (TE), 3-dehydro-6-deoxoteasterone (6-deoxo3DT, 6-deoxo3DHT) to 3-dehydroteasterone (3DT, 3-DHT), and 6-deoxotyphasterol (6-deoxoTY) to typhasterol (TY), but not castasterone (CS) to brassinolide (BL) (PubMed:15710611).
What are the official names of this protein?
Cytochrome P450 85A1, LeCYP85A1, C6-oxidase, Castasterone synthase CYP85A1, Protein DWARF.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CGLR1_DROSI
Sequence: MSSIRYHSSAFDDGSFSVMARNLENMVNRANAQYVKIDKHREPYTVHYNALRDKVYSEWKESGVLGTLLKGSTLCGGYGDKLKVSMPDEFDLLIHLVFPENDKIIVKADASKKGNVILDMTKVMEIIGSQEHNKPVFDLLQKIVNKKKQLLEDKLNSLLQSIMTQTLNKMGNQIEVAGRISHLEYKKCGPAHTIFVKGPCEYSVDFVPAIRLSAAQVVLAPEQRRHFGGTLYWDAIPKPMKPAKTDNASFRASFYEAERSLLLGKQSLKPAIRLLKQNRNVKNKANLKSYHIKTLFLWQVVQQDASYWSNSPKDIFIEMLGKLADSLALTPKKGKLPFFWDPKLDMFAELTDSQRTDLFNHFRKCEYTFRKDNGNVNDCTENNVHSSFSINTR
What is the function of this protein?
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:34261127).  Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (By similarity).  Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127).  Directly binds dsRNA longer than 35 bp, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (PubMed:34261127).
What are the official names of this protein?
Cyclic GMP-AMP synthase-like receptor 1, Ds-cGLR1, cGLR1.
What is the protein family that this protein belongs to?
Belongs to the mab-21 family.
Protein: ISPD_THEVB
Sequence: MHILIPAAGMGKRMGASHNKLRLQLLGKPLLAWTLAAVAAAEAIEWIGVIGQPEDFPIWEALLEDLNLRQPVHLITGGETRQASVFHGLQALPKTAEQVLIHDGARCLATPDLINRCAQALGTYAGLIAAVPVKDTIKIVNREGVVVQTPERDSLWAAQTPQGFRVEPLRIAHEMAVAKGWEVTDDAALFERLGYAVHIVLGEETNLKITTPSDLPLAERILQHRREQEQDTLG
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: RSMH_MYCTA
Sequence: MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCHF_HAEIN
Sequence: MGFKCGIVGLPNVGKSTLFNALTKAGIEAANYPFCTIEPNTGVVPMPDPRLDALAEIVKPERILPTTMEFVDIAGLVAGASKGEGLGNKFLANIRETDAIGHVVRCFENDDIVHVAGKIDPLDDIDTINTELALADLDSCERAIQRLQKRAKGGDKEAKFELSVMEKILPVLENAGMIRSVGLDKEELQAIKSYNFLTLKPTMYIANVNEDGFENNPYLDRVREIAAKEGAVVVPVCAAIESEIAELDDEEKVEFLQDLGIEEPGLNRVIRAGYALLNLQTYFTAGVKEVRAWTVSVGATAPKAAAVIHTDFEKGFIRAEVIAYEDFIQFNGENGAKEAGKWRLEGKDYIVQDGDVMHFRFNV
What is the function of this protein?
ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner (By similarity).  Does not hydrolyze GTP.
What are the official names of this protein?
Ribosome-binding ATPase YchF.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
Protein: SYP_CHLPN
Sequence: MKTSQLFYKTSKNANKSAAVLSNELLEKAGYLFKVSKGVYTYTPLLWRVVSKMMNIIREELNAIGGQELLLPLLHNAELWQHTGRWEAFTSEGLLYTLKDREGKSHCLAPTHEEVICSFVAQWLSSKRQLPLHLYQIATKFRDEIRPRFGLIRSRELLMEDSYTFSDSPEQMNEQYEKLRSAYSKIFDRLGLAYVIVTADGGKIGKGKSEEFQVLCSLGEDTICVSGSYGANIEAAVSIPPQHAYDREFLPVEEVATPGITTIEALANFFSIPLHKILKTLVVKLSYSNEEKFIAIGMRGDRQVNLVKVASKLNADDIALASDEEIERVLGTEKGFIGPLNCPIDFFADETTSPMTNFVCAGNAKDKHYVNVNWDRDLLPPQYGDFLLAEEGDTCPENPGHPYRIYQGIEVAHIFNLGTRYTDSFEVNFQDEHGQTQQCWMGTYGIGVGRTLAACVEQLADDRGIVWPKALAPFSITIAFNGGDTVSQELAETIYHELQSQGYEPLLDDRDERLGFKLKDSDLIGIPYKLILGKSYQSSGIFEIESRSGEKYTVSPEAFPTWCQNHLA
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.