PharMolix/UniProtQA huggingface dataset:
Protein: COAA_CORDI
Sequence: MARDKDLSPYLDFDRETWRHLRMSMPQVLTEQEVVELRGIGENIDLDEVAEVYLPLSRLIHLQVHARQELTQATETFLGEKAPHIPFVIGVAGSVAVGKSTTARLLQVLLQRWDEHPRVDLVTTDGFLHPTEILKKRGILDRKGFPESYDQRALLRFVTDVKAGKAHVKAPVYSHTLYDRVENECVTVSRPDILIVEGLNVLQTGPTLSVSDLFDFSVYVDAALEDIERWYIDRFLKLRQLAFRAPNAHFSHYADMGDRAATDEARRIWQTINLPNLVEHILPTRVRASLVLCKGADHKVARVRMRKI
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y682_PSEPK
Sequence: MERILENAMYASRWLLAPIYFGLSLGLLALALKFFQEVVHVLPNVFALSEADLILVILSLIDMSLVGGLLVMVMISGYENFVSQLDIDESKEKLNWLGKMDSSSLKMKVAASIVAISSIHLLRVFMDAQNISTDYLMWYVIIHMTFVVSAFCMGYLDKLTKH
What are the official names of this protein?
UPF0114 protein PP_0682.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MBP_PANTR
Sequence: ASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSGHRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGAQDAQGTLSKIFKLGGRDSRSGSPMARR
What is the function of this protein?
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS.  Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers.  Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
What are the official names of this protein?
Myelin basic protein, MBP.
What is the protein family that this protein belongs to?
Belongs to the myelin basic protein family.
What are the subcellular locations of this protein?
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
Protein: MIAB_ANAMM
Sequence: MTKGLYIESYGCQMNVYDSLMVEDILRPLGFAAVQRPEDADIIMVNTCHVREKAAEKLYSALGRMRMLRKEGALIVVAGCVAQAEGEAVFERAPFVDVVVGPQSIHTLPELIMKATRDAKQMNVEFPAISKFDVISTDLLVSRGVSAFVSVQEGCDKFCTFCVVPYTRGPEYSRSVEDVLAEVRKLADGGTKEVVLLGQNVNAYHGTYKGNEWDLGRLIRKVAEVEGIERIRYTTSHPRDMHSSLYDAHKHEPKLLPCVHLPVQSGSDSVLRKMNRKHSVQEYMDIIDTLKEARSDIALSSDFIVGFPGETEEDFEATMDLVRHVGFATSYSFKYSPRPGTPGAEYTNQVPEEEKSSRLHRLQHLLLTQQRLFTKSMIGKTVSVLVCGTEGSRSCSNEVFGKSEHMQPVYISVDGDPAGYRNKIFSVKVLEEGARSSLKGIICTDTISLPPPHSM
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBHB_ECO57
Sequence: MNKSQLIDKIAAGADISKAAAGRALDAIIASVTESLKEGDDVALVGFGTFAVKERAARTGRNPQTGKEITIAAAKVPSFRAGKALKDAVN
What is the function of this protein?
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
What are the official names of this protein?
DNA-binding protein HU-beta, HU-1, NS1.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RB8AB_XENLA
Sequence: MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGADEGTRTRIREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFGEFGEIKNIHLNLDRRTGFLKGYALVEYETYKEALAAMEGLNGQDLMGQPVSVDWGFVRGPPKGKRRSGRRRSRSPERRRR
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome (By similarity).  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs.  Associates preferentially with mRNAs produced by splicing.  Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs.  Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity).
What are the official names of this protein?
RNA-binding protein 8A-B, RNA-binding motif protein 8A-B, Ribonucleoprotein RBM8A-B.
What is the protein family that this protein belongs to?
Belongs to the RBM8A family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: IF3_CHLTE
Sequence: MKKQKTSGNQKPKVSYRINEQIRVPEVRVVFPEGGMQVMKTQDARRMAEERGIDLIEVQPNAQPPVCKLENYGKLIYKMDKKDKDLKKKQKTTSLKELRFHPNTDKHDFDFKTAHLEEFLRKGNRVRATIVFLGRSIIYKDKGFELADRLTERLSTVANRDGEPKFEGKKLFVYFEPDKKKIEQFEKQRAMAEKIASLPPLPPDNSGEPEDDE
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMH_CORU7
Sequence: MAANTPHDPSSPGHVPVMRQRMVELVGIGVTAGSAPAQPIIVDGTLGAGGHTEAFLEAYPNAIVIGLDRDPNALAEARARLERFGQRFFSYQTRFDGIGEALEHFSEDPDFPVDIREQGISGFLFDLGVSSMQLDQEDRGFAYRVDAPLDMRMDPSSRLTAAEILNTYEHGELARILKRYGDEKFAGKIASAVIREREKQPFENSARLVDLLYATIPAAARRTGGHPAKRTFQALRIEVNAELESLELVIPAAFSWLRVDGAGVFMSYQSLEDKIVKQQLKGMTESSTPPGLPVELPGTEPEFELLTRGAEKASEQEIAENSRSAPVRVRAARRIGAHASGAGGPRYPLVSTH
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_ECO24
Sequence: MSDNDTIVAQATPPGRGGVGILRISGFKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLYDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNDVIADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWPEFIARLPAKLPITVVRNKADITGETLGMSEVNGHALIRLSARTGEGVEVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLAEELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_DESA1
Sequence: MAKGPRYKVPRRRRREGKTNYYKRYRMIVSGHPRFIVRKTLNYIWVQVATARPEGDVIIAAAHSNELRKRFGWKAGTCNTSAAYLTGLLAALRALEKGVEYAVPDIGLHRPVKGALVFAAIKAANDAGLKVPMGGEVAPSEERIRGEHIASYAKILRENGLLEKRFSRYLANGLQPEDLPSHFEEVKNKILEAYKR
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: DABA_STAS1
Sequence: MGVSKIESTQASTYIDDIHDKVTRASNVIVPLSPISVFAARSPWARLEHKSFDEIAHWLKETRKVDMYPARMTILEANQKGEIDDAYVEQFFQQWLNDTALKIPRENAAQYGRNALKLETLETPTDIKSQLEALVSDLNEQVKFESENTVPLKSTYILDEKNERLIDTVDYHTIKWCKLYIDDAQSGWTMPNRDKGLFYAWRRLVAYDPALTKDQRARLKSLPNEAEDLMQQALSYLNISEADAQTYLENHLLSLPGWAGMMLWQDEHNHKVHDLLFSYLAIRIAMEWAIVEPYLPVSQPEDLNDMNKEELIASWIQWGNFSMQSWKALSIEAQQAHIQFAYRFNEQFCRKLWLDAWEATYNQQLKAMIGPKSSVEAEQQSQTLVQMAFCIDVRSEPFRKHIEANGPFETIGIAGFFGLPIEKAELGKKYSHPSLPVMNQPQHKIKEYTHEHEPNAFQQRKHALESVTYTFKKMKQNVLPSLLLPELSGPWLSLQMFTRSFIPKSVGSVIRKFYTSWLKKPNDTALTLNYEPQHQHNHRHIHLEDDLPVGFTDEEKVNYALQALKLMDLTDDFAPLVVMCGHGSQSANNPYAASLDCGACGGAASGFNAKVLAQLCNLPEVRQGLLQEGVAIPETTIFAAAEHQTSIDTLTWIYVPKLTEAARNAYENIEAAMPKISYQANKKRLSQLPNNNLTNRNPNHEVYRLTNDWSEIRPEWGLAKNAAFIIGQRELTKQSDLAGRAFLHNYNWKNDENGTILENIIAGPALVAQWINLQYYASTVAPHYYGSGSKTTQSVTAGIGVMQGNASDLLTGLPWQSVMSADNKMYHSPIRLVVVIQAPQAFISRLLENDETFKQKVMHGWVRLASVDEDNHWHEWSNEVKKFS
What is the function of this protein?
Part of an energy-coupled inorganic carbon pump.
What are the official names of this protein?
Probable inorganic carbon transporter subunit DabA.
What is the protein family that this protein belongs to?
Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ETRA_SHEON
Sequence: MTIEQNKNRRSAASGCAIHCHDCSMGTLCIPFTLNANELDQLDDIIERKKPIQKGEQIFKSGDPLKSLFAIRSGTIKSYTITEQGDEQITGFHLAGDVIGFDGIHAQSHQSFAQALETSMVCEIPFNILDELSGTMPKLRQQIMRLMSNEIMSDQEMILLLSKKNAEERLAAFISNLANRFGNRGFSAKEFRLTMTRGDIGNYLGLTVETISRLLGRFQKSGLIEVKGKYIIIVDHHELNLLAGNARIAR
What is the function of this protein?
Regulates anaerobic growth on fumarate, nitrite, Fe(3+), TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn(4+).
What are the official names of this protein?
Electron transport regulator A.
Protein: CWC24_SCHPO
Sequence: MEQKNLNINQASGSKINTELAVPIFQSRRRHRPRQGLKRKKGFKRDDDSGGSSESSNEDMRDNIPIVSGRKKTVRLNRLQRESEQFENSALKDINVEYQSNLSATGESVNTTTVSAINEDTREVILGRPSPKLANQSTLPTELFQSQNDYSRFLPKRKDFEKKSQVGPVLSSNASTVRMNTIIDYQPDVCKDYKLTGYCGYGDTCKFLHMREDYKAGWQLDREWDSVQEKYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYRSPIATTCGHHFCEQCAITRYRKTPTCIQCGADTKGLFSVDKNFDRLLKNRKSKNDEAVKQKVGGFESNNSATTEVSERKDREASFQGFADTLAKPNTSAQQKMPSLGDNSNTIISKYFIREITESNIVHFKRLVRVVLEASYSDKFYRLVLKNPDYARIATFEDKFVGAISSLVAEDNSLYVTVLCVLAPYRCLGIGSLLIDHVKKTAINNNIDRISLHVQTTNESVIKWYTAHGFKIVKQINDFYRRLENKSAFYMVCPLSAHNNIISNH
What is the function of this protein?
Involved in mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor cwf24, Complexed with cdc5 protein 24.
What is the protein family that this protein belongs to?
Belongs to the CWC24 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPA_PSEP1
Sequence: MSRLEQRFAELKAEGRSALVTFVTAGDPGYDASLQILKGLPAAGADVIELGMPFTDPMADGVAIQLATLRALEAGQTLAKTLQMVREFRVDNQTTPIVLMGYYNPIHRFGVDTFVAEAKAAGVDGLIIVDLPPEHDAELATPAQAAGIDFIRLTTPTTDDARLPRVLERSSGFVYYVSVAGVTGAGSATTEHVTEAIARLRRHTDLPISVGFGIRTPEQAANIARLADGVVVGSALVDKIAQAKSADQAVTDVLSLCSALAEGVRGARR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: GRPE_METTP
Sequence: MADELSEKSVEGTEEDGESAPAEGTTEGVPVDEVAKLRQELEDVKRIADERLEQLLRCRAELDNVIKRNSREREELARFASEAIIKKLLVFLDSLEQAAKHDEGAKALYDQLLDIMRSEGLEPIDAVGKKFDPFVHEAMMQVESQEAEDGIVVQEFQKGYTLHSRVIRTSKVAVAKHG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_SALTO
Sequence: MLDVNFFDELRIGLATADDIRQWSHGEVKKPETINYRTLKPEKDGLFCEKIFGPQRDWECYCGKYKRVRFKGIICERCGVEVTRSKVRRERMGHIELAASVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFASYVVTSVDAEARHRDLATIENEILAEKRQSENSRDSEIEKRAGKLEADLAELEAEGAKADVRRKVKEGGEREMRQIRDRAQREIDRLDEVLDTFRKLEPKQLVTDELLYRELRDRFGEYFTGGMGAEAIKALVQNMDLDAEAESLRETIRTGKGQRKIRALKRLKVVAAFLNTSNSPLGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKLHQCGLPKQMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPVVWDVLEEVIGEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQIHPLVCTAFNADFDGDQMAVHVPLSAEAQAEARILMLSSNNILKPADGKPVTMPTQDMIIGLYHLTHRTPGERGEGRAFSSDAEARMAFDNGELHLQAPVKIRLRGLVGVESGPGAEPWTAPEGWVEGDPITVETTLGRVLFNETLPPGYRFVNYEIRKGQLSAIVNDLAERFPKVALAATLDGLKEAGFHWATWSGVTIGMEDVLAPPRKREILGRYEKEADRIDKQYQRGLMTAEERRGELIEIWTKATNEVAKEMDTALPQENPLWKMINSGARGNLLQLRQIAAIRGLVANPKGEIIPRPIKASYREGLSVLEYFISTHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREEDCGTDRAIPMQVGQQAGEAGSLVVHEHAETSVHARTLADDIKGPDGTVVAERGADINSILVDKIVAAGVESVRVRSVLTCESKLGVCGACYGRSLPTGKTVDVGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGEDITQGLPRVQEIFEARIPKGKAPIADTPGRVRIEDGERSRKIIVVPDDGSDEIAYDKISKRVRLLANDGDHVEVGERLTVGTIDPHELLRILGPRAVQVHLTQEVQEVYRSQGVLIHDKHIEIIIRQMLKRVTVIDSGSTEFLPGVLVDRALFESENRRLVSEGGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAIHARSDSLIGLKENVIIGKLIPAGTGISKYRNVRVEPTEEAKAKVYSMTGYPETDYGFGPASGQAVPLDDFDFGSYR
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: PNP_CHESB
Sequence: MFNHHKVEIEWGGRPLILETGKIARQADGAVLATYGETVVLATVVSAKEPKPGIDFFPLTVNYQEKTFAAGKIPGGYFKREGRPSEKETLVSRLIDRPIRPLFVEGYKNDTQVIITVLQHDLENDPDILSMVAASAALTLSGVPFMGPVGAARVGYVGGEYILNPHLDEMAETKLDLVVAGTSDAVLMVESEAHELPEDVMLGAVMFGHRNFQPVIDAIIKLAEVAAKEPREFLPEDLSALEAEMLKVVEADLRDAYKITNKQARYDAVNAAKAKVKEAFLPEGAEAYKWTPEQVATVFKALQAKIVRWNILDTGSRIDGRDLRSVRPIVAEVGVLPRTHGSAVFTRGETQALVVATLGTGEDEQYVDSLTGTVKETFMLHYNFPPYSVGETGRMGSPGRREIGHGKLAWRAVHPLLPAPEQFPYTIRVVSEITESNGSSSMATVCGTSLALMDAGVPLAKPVAGIAMGLIKEDDRFAVLSDILGDEDHLGDMDFKVAGTAEGVTSLQMDIKITGITEEIMKVALEQAKDGRLHILGEMANALSESRGELGEFAPRIEVMHIPTDKIRDVIGTGGKVIREIVEKTGAKINIEDDGTVKIASSNGKEIEAARKWIHSIVAEPEVGEIYEGTVVKTADFGAFVNFFGPRDGLVHISQLAPERVQKTTDVVKEGDKVFVKLMGFDERGKVRLSMKVVDQETGKEIVQEKKEEKQEAEG
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIME_RAT
Sequence: MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFDCWETSIGAPGVSMHSATSIEDPVRQALGL
What is the function of this protein?
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
What are the official names of this protein?
Mevalonate kinase, MK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome.
Protein: RUVC_CHLTE
Sequence: MIVLGIDPGSRKTGYGVIAETAAGYRVLGCGLVRPRAADTLHERISQLCAGLDEVIEQLKPEAVALETAFVGRNVRSALILGQVRGAVLATVMRHSLPVREYAPREIKLSVTGTGSACKEQVAAMLSRMLELGGELKPLDVTDALGIAYCDLARGASSLGGQLRKNGKGRSKGWAAFVNEHPELMA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: HMG1A_CHITE
Sequence: MAEKPKRPLSAYMLWLNSARESIKKENPDFKVTEIAKKGGELWRGMKDKSEWEAKAAKMKEEYEKAMKEFERNGGDKSSGASTKKRGKAAEKKKPAKKSKKKDSEDDEEEDESD
What is the function of this protein?
Found in condensed chromomeres.  Binds preferentially to AT-rich DNA.
What are the official names of this protein?
Mobility group protein 1A.
What is the protein family that this protein belongs to?
Belongs to the HMGB family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: CXB2_MOUSE
Sequence: MDWGTLQSILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHHFPISHIRLWALQLIMVSTPALLVAMHVAYRRHEKKRKFMKGEIKNEFKDIEEIKTQKVRIEGSLWWTYTTSIFFRVIFEAVFMYVFYIMYNGFFMQRLVKCNAWPCPNTVDCFISRPTEKTVFTVFMISVSGICILLNITELCYLFVRYCSGKSKRPV
What is the function of this protein?
Structural component of gap junctions (PubMed:15692151).  Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells.  They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity).  Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151).
What are the official names of this protein?
Gap junction beta-2 protein, Connexin-26, Cx26.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Beta-type (group I) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Note=Colocalizes with GJB4 at gap junction plaques in the cochlea.
Protein: S40A2_ORYSJ
Sequence: MGMVTATAAAALLASPPQGHLGRRCHLVVPGLRLRPPASSSPPHAAPPLRLSNFVPRCYITNVEVDVSHTSEQEALDDHPPLLPACAIPVVHLRDVPDASPFPLHESASHSTDFEELPVLSEGELHTIAATPAHPAGLYALYASYLFGNLVEQLWNFAWPAALAILHPSLLPVAIVGFFTKLSVFIGAPIVGKLMDHFPRIPMYTGLNAVQVATQLISAAMVIYAMKNVTHASTSAVVLKPWFIALVAAGAIERLAGLALGVAMERDWVVLLAGTNRPVALAQANAVLNRLDLVCETVGASVFGLLLSKYHPVTCLKIACGLMICSFPVLVVLGQLINRFSCHALDSSRTPSEESICANLLDVRKIVQNGLSAIRNGWNEYKQQTVLPASVATVFLNFNVALAPGAIMTALLMHRGISPSIVGAFSGLCSIMGLVATFISSSLVERVGILKAGAAGLIVQASLLSVALVVYWTGSISQRTPLLIFLAAIALSRLGHMSYDVVGTQILQTGVPASKANLIGGMEVSISSLAELVMLGMAIIANDVSHFGFLAILSVSSVAGAAWMFCQWLGNPTDEQRELFMFDPHFQVEPI
What is the function of this protein?
May be involved in iron transport and iron homeostasis.
What are the official names of this protein?
Solute carrier family 40 member 2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Plastid, chloroplast envelope.
Protein: Y2882_JANSC
Sequence: MMHICHIEIDTQGLPAPTPEIEQERKVAIFDLLEENTFTLPHEDAPSGPYRLSLAIREKRLVFDIDTEDGAEAAEFHLSLAPFRQTVKDYWQICEAYFDAVKKLPPSQIEAIDMARRGIHNEGARLLQERLEGKAEIDTDTARRLFTLICVLHFGA
What are the official names of this protein?
UPF0262 protein Jann_2882.
What is the protein family that this protein belongs to?
Belongs to the UPF0262 family.
Protein: COBS_SHEPC
Sequence: MSERESWHKEIDLFLVAMGYFTRIPMPKWVEVDSDKLNKASRYFGLVGLLIGLLSAIVFWLTQNWLPAGVSVLLAMLVGVLLTGGFHEDGLADTFDGFGGGWTAEDKLRIMKDSRLGSYGAIALILALLLKWQLLVELALYDPVVAGSALIVAHTVSRVVAASIIFTEKYVRDDETSKSKPLSQHQGINELFILVASGVLVLLFLKGLAALSLLLVMIGLRRLIVVIFRRQIGGYTGDTLGAAQQICEIVCYLVLLIVGSIL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: E4PD_ECO24
Sequence: MTVRVAINGFGRIGRNVVRALYESGRRAEITVVAINELADAAGMAHLLKYDTSHGRFAWEVRQERDQLFVGDDAIRVLHERSLQSLPWRELGVDVVLDCTGVYGSREHGEAHIAAGAKKVLFSHPGSNDLDATVVYGVNQDQLRAEHRIVSNASCTTNCIIPVIKLLDDAYGIESGTVTTIHSAMHDQQVIDAYHPDLRRTRAASQSIIPVDTKLAAGITRFFPQFNDRFEAIAVRVPTINVTAIDLSVTVKKPVKANEVNLLLQKAAQGAFHGIVDYTELPLVSVDFNHDPHSAIVDGTQTRVSGAHLIKTLVWCDNEWGFANRMLDTTLAMATVAFR
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_RHOP2
Sequence: MESPIRFADVDINTILKTLPHRFPFLLIDRVKNIREDHSGIGVKNVTFNEPAFQGHFPERPVFPGVLMIEGMAQTAGVIGIMSVTGTEKPRAVYFLTIDKCKFRKPVLPGDTIEYHMKSIGRRKTMWWFHGDAIVDGQTVAEADVGAMLTD
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1111_RUEPO
Sequence: MSVGYDRLKTSSLAELRAAIRSGAYRSHTAGLGQGYLQANLAILPEAYALDFMRYCQRNPKPCPLIGVSDTGNPMMFTLGRDIDIRTDVPAYNVYRDGRLDSVSADITEDWRDDLVVFALGCSFTFEHAVMRAGVALWHVDNDRTVPMFRSNIETVPAGPFSGKMVVSMRAVPEDRVAEVAEISRAYPLAHGAPVYWGDPAGLGIADIMSPDWGDPAPLGPGEVPMFWACGVTPQVAIEAARLPLCITHKPGHMLITDVAEDAEVPVVETAQDKR
What are the official names of this protein?
Putative hydro-lyase SPO1111.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.