PharMolix/UniProtQA huggingface dataset:
Protein: T2R13_PANPA
Sequence: MESALPSIFTLVIIAEFIIGNLSNGFIVLINCIDWVSKRELSSVDKLLIILAISRIGLIWEILVSWFLALHSLAIFVSGTGLRIMIFSWIVSNHFNLWLATILSIFYLLKIASFSSPAFLYLKRRVNKVILMILLGTLVFLFLNLIQINMLIKDWLDRYERNTTWNFSMSDFETFSVSVRFTMTMFSLTPFTVAFISFLLLVFSLQKHLQKMQLNYKGHRDPRTKVHTNALKIVISFLLFYASFFLSILISWISELYQNTVIYMLCETIGAFYPSSHSFLLILGNAKLRQAFLLVAAKVWAKR
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 13, T2R13.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DCL1_COCIM
Sequence: MEEPQRINDEPNDSVVPDPAGPSEPAESDSEDEHTHPNNADEPSIRRKQNLRFKELLSARAEEITAEDIKEVIKATKDDELSMSNLLAKQDFASVIHDPREYQVELFEKAKKDNIIAVLDTGSGKTLIAVLLLKHIIEQELIDRSAEKPHRVSFFLVDSVTLVFQQAAVLQNNINQRVDKFCGAMETDLWNGETWERHLAKNMVIVCTAEVLYQCLLHAFVKMENINLLIFDEAHNAKKDHPYARIVKDFYLKDGNAKRPKIFGMTASPVDAKMDVVKAARNLETLLNSQIATASNLSLLRQSVPRPNEEVWSYDRLDQPFETRLYKELRSRFGDLRALEKLFTFSLKASSNLGAWCADWVWSYALTEESLPKLEGRAARTAMGNLPIAKIVRPEAEIQRIREASEIIRSHKFGDPAVRPELLSPKVRRLHHELLKYFERHTDTKCIVFTEQRHTARILCDLFSRIGTKHLRPGVLIGVRSDASGGMNISFRQQVLAVVSFRKGEVNCLFATSVAEEGLDIPDCNLIVRFDLASTLTQYIQSRGRARHMNSTFAHLVERDNFVHRESVNHLQSSEEIMKRFCISLPKDRILNSDDVDALYESDRNRKSYTVQTTGAKLTYSSSLVVLAHFANSLQYEKETSTVVSYYHRFTKNAFVCEVVLPEKSPIRGIVGKPASKKLIAKQSAAFETCLLLRKHGLLDDHFVSTYHKRLPAMRNARLAISSKKSNQYDMKVKPKLWETSRGIIPTSLNIVVLGFRPRRLLHREYHPLVLLTREKLPHFPEFPLYLEDDIECDVICSSISSGFQVSSHDLEVLTTFTLRIFQDIFHKVYDRDVGMMTYWLAPLNLSCDISSSASRDLLDWGILQFVFDNPEIPWSSSNSAAFFANRFVYDRWDGRYRYFTHGIDPSLRPSDPPPSSMARRRHMGNIMDYCLSLFKNARKKFLENCDWTQPVIKAEIIQLRRNLLDKRTNKEKIKEGDYYICLEPLTISAIPASVAAFAFAFPAIISRIESYLIALEACQELDLPISPELALEALTKDSDNTDEHRAQQIHFQRGMGKNYERLEFLGDCFLKMATSISLFAMNPDNDEYDFHVKRMCLVCNQNLFKTAVRFKLYAFIRSQSFSRRGWYPGGLTLLQGKGQSKGATENKHALADKTIADVCEALIGACCLLASKNHRFDIAVKAVTALVSSDDHNVLNWEQYSRLYSIPKYQTAVVDAAELDLAAQVKKKLGYDFKYPKLLRSAFTHPSYPSAWARVPCYQRLEFLGDALLDMACVEHIYHKHPDKDPQWLTEHKMAMVSNKFLGSVAVRLGLHSHLNHFSTSLQSQITNYVEEIEAAELESGDPPDAWTLTSDPPKCLPDMVEAYIGAIFIDSGFSFEVVEEFFQKFLKKHFEDMTIYDTYANKHPTTYLHNRLAIDFGCSNYCLKAGEVPYVDGPGTRVLAAVIVHDEVVAEGVASSSRYAKLKASEAALSKLEGLPPFRFREIYGCNCQAGQSEAGNE
What is the function of this protein?
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway.  Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS).  Part of a broad host defense response against viral infection and transposons (By similarity).
What are the official names of this protein?
Dicer-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
Protein: FB131_ARATH
Sequence: MQRERSMKRKRRRRGIKDMCNRHDCEIPPDLMIEILIRLPTKSFMRFKCVSKQWSPLISGRYFCNRLFTCVTRQQQQQPRLYMCLVAKDKQCVLLSSTSPDNTCFVLVDQDLSIPGYFFASVPGLLCFQFGTKACIYNPSTKQLLTLPSVKSDITAQQGQLKTTQYYIGRDPVNDQYKLVCTILIYSKLFANMSSEHWVFTLELGGSWKKVVPLGNYHPHAPATAGRSIDGVVHYLAWVDLYKCAVVSFNIRSEEVTTFLLPRKIWDVPVPALMMKADLIEYDGKLAIFSHSYLKDEGLVELWVLKDAAGKKKWSNMILVLQPCQRHLVHGIDLIVKGTTQDGKVILSPLEMRSQFYILCYDVQNNDLRKVEITGVPRLWLHKECNFDLKFMDESESFIYLEI
What are the official names of this protein?
F-box protein At2g40925.
Protein: COAD_ZYMMO
Sequence: MDALSPKKQPIALYPGTFDPVTLGHLDIIRRGARIFDHLIIAVAENPGKSPLFSSEERASMIRHEISRLENPTKSRIEVIIYNSLLMDCVESQGASVILRGLRAVADFEYEYQMAGMNQQINNKIETVFLMADSVLQPVASRLVKEIAFYNGNITPFVPPYVVQKLQEAVTRKKSFQD
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_METSB
Sequence: MNGQNIRIRLKAFDHRILDTSTKEIVSTAKRTGAHVRGPIPLPTKIEKFTVNRSPHVDKKSREQFEIRTHKRVLDIVDPTPQTVDALMKLDLAAGVDVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: DBR1_ARATH
Sequence: MKIAIEGCMHGDLDNVYKTIQHYEQIHNTKVDLLLCCGDFQAVRNEKDMDSLNVPRKYREMKSFWKYYSGQEVAPIPTIFIGGNHEASNYLWELYYGGWAATNIYFLGFAGVVKFGNVRIGGLSGIYNERHYRSGHFERPPYNESTIRSVYHVRDYDVQKLMQLEEPLDIFLSHDWPVGITDYGDSESLMRQKPYFRQEIEEKTLGSKPAALLLEKLKPQYWFSAHLHCKFAAAVQHGNDGSVTKFLALDKCLPGKKFLQIIEIESEPGPFEVLYDEEWLAITRKFNSIFPLTRRYTNVSTAGTIQESREWVRKKLEERQFKPFEFARTVPAYNPSQRVFDSIPEIPQNPQTLSLLELLGLPYLLDSSPVTGERTDIPASLAPSDLPTYDSEEIPIDDIDEIEEMEEAKADDHTRDDA
What is the function of this protein?
Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded.  It thereby facilitates ribonucleotide turnover.  It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.  Plays en essential role during embryogenesis.
What are the official names of this protein?
Lariat debranching enzyme, AtDBR1.
What is the protein family that this protein belongs to?
Belongs to the lariat debranching enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARC_BIFLD
Sequence: MSDTEDLAALNDRLMAKNHALAEALSRAGKELTKAKSQLAQLAQPPLTFATMVKVDSTRTDEDGIQHASAEVISGTRRMVVPVASNVNAARLTAGATVMLNEKLVLVEQRDADTVGQIRSVKQVLDDGRLIVTDASGNPVLIRRSGALAYAGINQGDRIIIDPSVRLAIEALPAEGDKDLVLEETPDVTFADIGGLDSEIGRIRDAVQLPFQHRALFERYDLKPPKGVLLYGPPGNGKTMIAKAVANALCEGGYDSNGDGAISPAETHVKGVFLSVKGPELLNKYVGESERLIRLIFQRARERAADGNPVVVFIDEMDSLLRTRGSGVSSDVETTIVPQFLSELDGVESLDNVMVIGASNRVDMIDPAVLRPGRLDVKIRVGRPKTNQAIAIVDHYLTDDLPLEDGVDAHALSAVLVHDIYGTSERRHLCDVQEENGQWHALFLADVVSGAMLKNIVDRAKTRAVKESIETGLDVALTVPLLAAAVEDEYRETRDSMADVDPEQWSRINGMDPIRRIRTAE
What are the official names of this protein?
AAA ATPase forming ring-shaped complexes, ARC.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: RIMP_HERAR
Sequence: MQLSALIEKTVVGMGYELVNFEQAARGLVRVYIDFTPEDADKGSITVEDCEKVTHQLLHVLTVENANYERLEVSSPGLDRPLKKLSDYVRFAGAEALVKLRLPMPNAANRKSFQGILQEPVGETLALEFEGNEGPAKLEFTLADVDKAHLVPQVNFRSRKA
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GDF8_CHICK
Sequence: MQKLAVYVYIYLFMQIAVDPVALDGSSQPTENAEKDGLCNACTWRQNTKSSRIEAIKIQILSKLRLEQAPNISRDVIKQLLPKAPPLQELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLVQMEGKPKCCFFKFSSKIQYNKVVKAQLWIYLRQVQKPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKAFDETGRDLAVTFPGPGEDGLNPFLEVRVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
What is the function of this protein?
Acts specifically as a negative regulator of skeletal muscle growth.
What are the official names of this protein?
Growth/differentiation factor 8, GDF-8, Myostatin.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RXLRD_PHYIT
Sequence: MLPYKTLLLALGFFFTVQCHFFASASSFDIADNNQNGVRLLRSPEKTDEERGAVDALKSELSFMKLNWAARSKITPKEKLVAKQAKEMSNTKEKLSKIEAKLQAKAVKAEQKVKDQAIKAEQNLKAKNEKAAQQLKALQQNELEKLAKQAAKDDKMYNRWLMAEMTPDDVYKKFKFKELAKKGIYPTTSVNYKHYKNYRTIYYARYPKLLEKLDA
What is the function of this protein?
Effector that might be involved in host plant infection.
What are the official names of this protein?
RxLR effector protein PITG_00582.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane.
Protein: UBIG_ECOLC
Sequence: MNAEKSPENHNVDHEEIAKFEAVASRWWDLEGEFKPLHRINPLRLGYIAERAGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIQVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYILRMVPKGTHDVKKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQNK
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-octaprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone-8 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: SURE_STRMK
Sequence: MRILVSNDDGVDAAGIRMLASVLREAGHEVTVVAPDRDRSGASNSLTLDLPIRLKRIDHYTVSVAGTPTDCVHLALTGLLEFEPDIVVSGINNAANLGDDVIYSGTVSAAMEGRFLGLPAVAVSLVTRNHDPKHFETAARAAVEIVARLKADPLPADTILNVNVPDLPWNEVKGFEVTRLGNRHRAEGCIAQKDPRGNEVYWIGPAGREQDSGPGTDFHAVRTGHISITPIQVDLTRYQALEKVASWVGGLSAALDQPA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_AGRRK
Sequence: MAELKPFLAKVANREVLTRDEARQAFDILMSGEATPSQIGAFLMALRVRGETVDEIVGAVTAMRAKMLPVEAPADAIDIVGTGGDGFGTYNISTLAAFIVAGAGVPVAKHGNRAQSSKAGTADTQSVLGIKLDIGPEVIARCIREAGIGFMFAQLHHSSMRHVGPSRVELGTRTIFNLLGPLANPAGARRQLLGVFAPQWVVPLAEVLKDLNAESVWVVHGNGLDEITTTGTTSVAALEDGKIRTFELTPADFGLAHADLADLKGGDGIANAAALRAVLSGEKNAYRDISLANAAASLVIAGKAETLHDGMKLAAQSLDSGATAAALEKLIAVSNDEE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: TSAD_MARN8
Sequence: MLILGIETSCDETGVALFDAQRGLLAHALYSQIGMHADYGGVVPELASRDHVRKLLPLCDEVLAQAGKARSDIEGIAYTAGPGLVGALMVGGSVAHALGFALGIPVLGVHHMEGHLLAPMLEDNPPAFPFVALLVSGGHTQLVRVDGIGEYQMLGESVDDAAGEAFDKTAKMLGLDYPGGPRVAALAEKGREGQYRFPRPMTDRPGLDFSFSGLKTFTLNTVNDAKDKGTLDEQVKADIALAFEAAVVDTLVIKCRRALEQTGCKRLVIAGGVSANKRLRASLEAMAEKLRGSVFYARPEFCTDNGAMIAYAGAQRLKAGQQDGERIVAVPRWPMNTLPPVAEPRQNGLVD
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MBL2_MACFA
Sequence: MSLFPSLTLLLLSVVATSYSETVTCEDSQKICPAVIACNSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGSSGSPGPKGQKGDPGESPDCESSLAASERKALQTEMARIKKWLTFSLGRQVGNKFFLTNGEMMTFDKVKALCAEFQASVATPRNAAENRAIQNLIKEEAFLGITDENTEGEFVDLTGNKLTYTNWNDGEPNNAGSNEDCVLLLKNGKWNDIPCSSSHLALCEFPI
What is the function of this protein?
Calcium-dependent lectin involved in innate immune defense.  Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.  Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
What are the official names of this protein?
Mannose-binding protein C, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin.
What are the subcellular locations of this protein?
Secreted.
Protein: RS13_EHRCR
Sequence: MARIAGVNIPTNKRIVIALTYIYGIGLSLANRICEGCNIDHNVRVVNLSDDEIIRIRNFIRENYIVEGDLRKEVSMNIKFLTDIGCYRGLRHRRGLPVRGQRTHTNAKTRKGRSKLPVAAKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: PDLP1_ARATH
Sequence: MKLTYQFFIFWFFLPFFAISGDDDYKNLIFKGCANQKSPDPTGVFSQNLKNLFTSLVSQSSQSSFASVTSGTDNTTAVIGVFQCRGDLQNAQCYDCVSKIPKLVSKLCGGGRDDGNVVAARVHLAGCYIRYESSGFRQTSGTEMLFRVCGKKDSNDPGFVGKRETAFGMAENGVKTGSSGGGGGGGGFYAGQYESVYVLGQCEGSLGNSDCGECVKDGFEKAKSECGESNSGQVYLQKCFVSYSYYSHGVPNIEPLSGGEKRQHTERTIALAVGGVFVLGFVIVCLLVLRSAMKKKSNKYDAY
What is the function of this protein?
Modulates cell-to-cell trafficking (PubMed:18215111).  Required for systemic acquired resistance (SAR) which is mediated by the signaling molecules azelaic acid (AzA), glycerol-3-phosphate (G3P), and salicylic acid (SA).  Required for the proper localization and stability of AZI1 which is involved in SAR (PubMed:27078071).  Mediates callose deposition during downy mildew fungal infection around haustoria.  Haustoria are unicellular protrusions from hyphae and function as the site of molecular exchange of nutrients and effectors between host and pathogen (PubMed:25393742).
What are the official names of this protein?
Plasmodesmata-located protein 1, PD-located protein 1, Cysteine-rich repeat secretory protein 56, Plasmodesmata localizing protein 1, Plasmodesmata-located protein 1a, PDLP1a.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family. Plasmodesmata-located proteins (PDLD) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, plasmodesma. Note=Co- localizes with the Grapevine fanleaf virus 2B-MP at the base of tubules within modified plasmodesmata. Co-localizes with Cauliflower mosaic virus movement protein. Utilizes the secretory pathway for delivery to plasmodesmata.
Protein: NHR27_CAEEL
Sequence: MERGSPGSSKSVSTFTPDSMSTYVSNCVVCGRLTSLFNYGAHSCSACGSFLRRTLASSKFLDDCKYSGNCFENFKRAIHFECKFCRLHKCVQKGMLDLSRYTHLERLICELSEFDSKRETLFLTMTVSNGFKAEELMWQSSVSLVKKPPHLVFNSHDWGFMNQVTIIDFLKKLEFSKFLSSQDLRSFLKCTHFTQVILKSAVISYNANQNYMSFPNKIDIFPETVTEGTSISVNLQNRIRCRLVNRLIELKVTHEEMLLLCAIAFSNPAIPELSENGRTLLNSYQNVYRSALFQYCSTAYQRNGPSRFNDLLFLLHVVTKTHDDIKKYFTLFQFFQPTEQPSQVHQDVIEFIN
What is the function of this protein?
Ligand-activated transcription factor (By similarity).  Involved in lifespan extension in a manner dependent upon mitochondrial function (PubMed:24107417).
What are the official names of this protein?
Nuclear hormone receptor family member nhr-27.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TSPO_BACCR
Sequence: MFMKKSSIIVFFLTYGLFYVSSVLFPIDRTWYDALEKPSWTPPGMTIGMIWAVLFGLIALSVAIIYNNYGFKPKTFWFLFLLNYIFNQAFSYFQFSQKNLFLATVDCLLVAITTLLLIMFSSNLSKVSAWLLIPYFLWSAFATYLSWTIYSIN
What is the function of this protein?
Binds tetrapyrroles and promotes the photooxidative degradation of protoporphyrin IX (PubMed:25635100).  Can bind the benzodiazepine receptor agonist PK-11195 (in vitro); this interferes with photooxidative tetrapyrrole degradation (PubMed:25635100).  May play a role in the transmembrane transport of tetrapyrroles and similar compounds (By similarity).
What are the official names of this protein?
Tryptophan-rich protein TspO.
What is the protein family that this protein belongs to?
Belongs to the TspO/BZRP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Protein: IFF9_CANAL
Sequence: MQLFQNILVSIALLTQIVFAIEITENKVDRGTVTLNLSDITIYPGASWSIIDNAYTSFVGKLDVRDGAGLYISSTSHLLALQVSLTALLHSITNNGVVSFDSRISRTSSSYDLRGVSFTNNGEMYFAASGEFSSPTALTSASWTNTGLLSFYQNQRTSGTVSLGMPLGSITNTGQVCLNNQVYEQTTQIKGSGCFTANGDSTIYISNVLLAVSPKQNFYLTDKGSSMIVQAVSTTQTFNVYGFGEGNKIGLTIPLMGNLWNSAYAYDTTSGILTLRNLLLEQKFNIGTGYDPSKFQVVTDSGSGIPSTILGSVAYYGRVPERTLPKSCQIPCKPIPEAPGTTPTQYTTTITKTNTAGNTVTESGVVNVSTDKGGSWFTTTSMFPALSTAPSTATVFSSDTIMSTVEPDTTELASLTDIPIETSSVEELLSVMSNWEISSAPTLSIETPVSSHHSSMQHSSFESSADINTVFSSESAFETASDYIVSTPSSISHSTMVPQSSVSALSVVSESLASAEPSFVVPSESFIFSASSAAPQPSSSTYSVSFTTQFETPSSAGPSLVTSVESNTELISSATQSSDIQTEFTSTWTTTNSDGSVVTESGIISQSGTSLTTLTTFQPATSLVVPPYSVIETEFTSTWTTTNSDSSVATESGVVSQSDTLLTTVTTFPPAPSAIVPEFTSPWKINTSIESSETLTVSASSYETVGESLAAATSSYLSSATVVVAPSESEINTSSSILNNEEIASAPVSDTTSIAEHHDGSLSMTTTEFVNSNSLPSSHSIVTATITSCNKSKCSESVVTYVSSVSCATITVGDSEKNISTVGNNVSSIVGDDVSNTQAITMATSTEGATTLTSVSGAKPSVANDATNSVHTTDYTTATTGVQNGSSLSIPSDIPIEISVITPTNSSSSAITIPYENGSNKESIENIKYLALVVFGLMMFM
What is the function of this protein?
GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.
What are the official names of this protein?
Cell wall protein IFF9, Adhesin-like protein IFF9.
What is the protein family that this protein belongs to?
Belongs to the HYR1/IFF family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Protein: ADEC_OCEIH
Sequence: MNSTIEQLKHRIAVASKRKPAELVIKNAEVLNVFTGDWKKTDVAIADGYIAGLGNYEGLQTVDATGKKIVPGLINGHIHIESTMLTPREFSKVMLKHGVTTAITDPHEIANVAGTDGLEYMLNASDALPMNIFVNMPSSVPATQFEHNGAQLDAKDISSYFQNPNVLGLAEVMDFPSVANADQKMLEKIVSTIQHGGIIDGHAAGLSKEDLNIYMAAGIRNDHESVSAQEGKDRLEAGMYLMIREGTVAKDLEALLPIINDKNARRCIFVTDDMLLDDLVENGDIDHIIRKAIQLGLDPVMAYQMATLNTAECFGLRELGAVAPGYIADFLILNDENQVDIHQVYKNGKCVVDEGEINQSYFAASLTYDATTLPKPRIQQLKASDFSIDLTDDYCNIIEIVPNKIITNHVCERVEVKEGKFVPSVDKDQLLIAVVERHKGLGYIGKGIVKGFKMKEGAIATSVAHDSHNFVVVGTSEEEMLSAIKKVEQLDGGLVVTKRKQVKAHLALPIGGLMSDKDYLDAYEEVLKLNHVAVENGIPSNFNPFLTLSFLTLPVIPTLKVTDQGLFDFKTFSHINVEVEEK
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: LIPA_CRYNJ
Sequence: MVKLPSASRIRSLATVPSTATRAFATVNPTPPAAQPTKSKPRFEKLDDGLTFDDFLSGDVPPENERVVLGNTKQPRLPSFLKHPIPTGASYSGIKKELRGLGLHTVCEEAKCPNIGECWGGGKGNATATIMLMGDQCTRGCRFCSVKTSRAPPPLDVHEPENTAEAISRWGLGYIVLTSVDRDDLVDGGAAHIASTISKIKQKAPNILVEALTPDFATKGVNVIHTVASSGLDVFAHNVETVERCTPFVRDRRAGFSQSLKVLEEAKKGAKAAGREILTKSSIMLGVGEMEEEIHETLRRLRASDVDVVTFGQYMRPTKRHMKVDRYVEPEEFAKWKNVAEGMGFLYVASGPLVRSSYKAGEFFIENVLKKRRAAAAEHAASQLSTQPPEIAAKV
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: APOE_MACNE
Sequence: MKVLWAALLVTFLAGCQAKVEQPVEPETEPELRQQAEGQSGQPWELALGRFWDYLRWVQTLSEQVQEELLSPQVTQELTTLMDETMKELKAYKSELEEQLSPVAEETRARLSKELQAAQARLGADMEDVRSRLVQYRSEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLASQPLQERAQALGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQISLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGASTAPVPSDNH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.