PharMolix/UniProtQA huggingface dataset:
Protein: CTAA_CERS4
Sequence: MAVKKRSIFEEVGQGAKAPVPQGGSIDRGHGGARRGIRLWLMALFLLVMAMIVVGGLTRLTDSGLSITEWRPVTGAVPPLNETQWAAEFDKYRDSPQYRLMNAGMTLAEFQRIYWWEWGHRQLGRVIGLVWAVGFLGFLAARRIPRGWWPRLLALGALGGLQGGIGWWMVASGLEGDKVTVESTRLATHLGLAFIILGLIAWQALLLGRSESDLLQARRQKDGRLVTLTTVLIGVAFLQIVLGALVAGIDAGRGFPTWPDMNGTFLPAEMFYVPGVETDWRNPAWWLGLLQNPGFVQFLHRMAGYTLAALGLIFWIFGRRSRHRATRGAFDLLAMALLAQILLGVGTVLSAAEWQVAIAHQVGAVVIWVLILHARHLALYPRVGSIRKGTL
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABZ_LEGPL
Sequence: MNESIDINQIFTLLPHRYPFILVDRVIDYKVMEYLIAIKNVTINENFFTGHFPGNPIMPGVLMLEALAQASGILANLSRQPKEGYEFLHYFAGIDNARFKQVVIPGDQLRLEVRLVGQKRDFWRMHGEAYIGDKLACSADLLSATKEIKK
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_RHOP2
Sequence: MDKFTTLEGVAAPLKIINVDTDMIIPKQYLKTIKRTGLGKGLFSEQRYQDDGSENPDFILNKPAYRSAKILVAGDNFGCGSSREHAPWALLDFGIRCVISTSFGDIFYNNCFKNGVLPIRVSQDDLDKLFDDAERGSNATVTIDLPAQEIRGPDGGTVKFEIDPFRKHCLINGLDDIGLTLEKKASIDSYEDKLKTERAWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: KDSB_PSEU2
Sequence: MTAAFTVVIPARYGSSRFPGKPLKTIAGKPMVQLVWEQACKSSAERVVIATDDARIVEACQAFGAEVLLTRDDHNSGTDRLAEVAAQLGLAADAIVVNVQGDEPMIPPAVIDQVASNLAAHPEAGMSTLAEPIDDVAALFNPNIVKVATDINGLALTFSRAPLPWARDALAANRDQLPAGVPYRRHIGIYAYRAGFLHDFVSWGPCWLENTESLEQLRALWNGVRIHVADALEAPPGGVDTPEDLERVRRLLEG
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BAMD_PSEAE
Sequence: MQVKHLLLIAILALTAACSSNKETVDENLSESQLYQQAQDDLNNKSYNSAVTKLKALESRYPFGRYAEQAQLELIYANYKNMEPEAARAAAERFIRLHPQHPNVDYAYYLKGLSSFDQDRGLLARFLPLDMTKRDPGAARDSFNEFAQLTSRFPNSRYAPDAKARMVYLRNLLAAYEVHVGHYYLKRQAYVAAANRGRYVVENFQETPAVGDGLAIMVEAYRRLGLDDLASTSLETLKLNYPDNASLKDGEFVARESEADTRSWLAKATLGLIEGGEPPPHMETQAAKDVIKQYEDAEREIPAELKPENQDHSADDEKPESDDDEDSGRSWWSYMTFGLFD
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamD.
What is the protein family that this protein belongs to?
Belongs to the BamD family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: HXK2_EQUGR
Sequence: MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLAATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQKVEMENQIYAIPEDIMQGSGTQLFDHIAGCLANFMDKLQIKDKKLPLGFTFSFPCIQTKLDESFLVSWTKGFKSRGVEGRDVVTLIRKAIQRRGDFDIDIVAMVNDTVATMMTCGYDDQNCEIGLIVGMGSNACYMEEMRYIDTVEGDEGRMCINMEWGAFGDDGTLDDIRTEFDQEIDMGSLNPGQQLFEKMISGMYMGELVRLILVKMAKEELLFRGKLSPELLTTGRFETKDVSEIEGEKDGIQKAREVLVRLGMDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLQKTVRRLVPNCDIRFLCSEDGSGKGAAMVTAVAYRLAYQHRARLKTLEPLKLSREQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQDIMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNRLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNTEWGAFGDNGCLDDFCTEFDVAVDELSLNPGKQRFEKMMSGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALQQVRAILQHLGLESTCDDSIIVKEVCTVVAQRAAQLCGAGMAAVVDKIRENRGLDTLKVTVGVDGTLYKLHPHFAKVMRETVKDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
What is the function of this protein?
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively).  Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.  Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
What are the official names of this protein?
Hexokinase-2, Hexokinase type II, HK II.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein. Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis.
Protein: FGF1_CHICK
Sequence: MAEGEITTFTALTERFGLPLGNYKKPKLLYCSNGGHFLRILPDGKVDGTRDRSDQHIQLQLSAEDVGEVYIKSTASGQYLAMDTNGLLYGSQLPGEECLFLERLEENHYNTYISKKHADKNWFVGLKKNGNSKLGPRTHYGQKAILFLPLPVSAD
What is the function of this protein?
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration.  Functions as potent mitogen in vitro.  Acts as a ligand for FGFR1 and integrins.  Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades.  Binds to integrins.  Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
What are the official names of this protein?
Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, aFGF, Endothelial cell growth factor, ECGF, Heparin-binding growth factor 1, HBGF-1.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery (By similarity).
Protein: VG12_EHV2
Sequence: MTDKFYFYGLFWGILLFVFLQHMQGNVPPTPLPPLSSEDLVNRSATPQLPPTCDGNATTFGGVKFPKKKTPPACACKVLEKFSCMGSFGCIGYSWGCSCCCFKSCKNVTTSPLLQ
What are the official names of this protein?
Protein E6A.
Protein: RPOA_THET8
Sequence: MLDSKLKAPVFTVRTQGREYGEFVLEPLERGFGVTLGNPLRRILLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLKELVVRFLNPSLQTVTLLLKAEGPKEVKARDFLPVADVEIMNPDLHIATLEEGGRLNMEVRVDRGVGYVPAEKHGIKDRINAIPVDAVFSPVRRVAFQVEDTRLGQRTDLDKLTLRIWTDGSVTPLEALNQAVEILREHLTYFSNPQAAAVAAPEEAKEPEAPPEQEEELDLPLEELGLSTRVLHSLKEEGIESVRALLALNLKDLKNIPGIGERSLEEIKEALEKKGFTLKE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: YBEY_LACGA
Sequence: MNNLDISFNDEVNFLKNDDKDWIPWITNLLLSAKKEINKKNAQEMSINFVSSEKIHEINKKYRGKDRPTDVISFAIEDGLDEDFMAAFNDDPDFVEDIGDLFLCPEVIKRHSVEYETGFNREFGYTLVHGYLHLNGFDHIEDDEAKVMFGIQGKVLREYGLPLHPDQENHGKQIH
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LACA_STAAN
Sequence: MAIIIGSDEAGKRLKEVIKSYLLDNKYDVVDVTEGQEVDFVDATLAVAKDVQSQEGNLGIVIDAFGAGSFMVATKIKGMIAAEVSDERSGYMTRGHNNSRMITMGSEIVGDTLAKNVVKGFVEGKYDGGRHQIRVDMLNKMC
What are the official names of this protein?
Galactose-6-phosphate isomerase subunit LacA.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: PSAA_ARAAA
Sequence: VERDPIKTSFEKWAKPGHFSKTLSKGPNTTTWIWNLHADAHDFDSHTDDLEEISRKVFSAHFGQLAIILIWLSGMYFHGARFSNYEAWLSDPTHIKPSAQVVWPIVGQEILNGDVGGGFRGIQITSGFFQLWRASGITSELQLYCTAIGGLIFAGLMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWAGHQVHVSLPINQLLDAGVDPKEIPLPHEFILNRDLLAQLYPSFAKGLTPFFTLNWSEYSDFLTFRGGLNPVTGGLWLTDTVHHHLAIAILFLIAGHMYRTNWSIGHSLKEILEAHKGPFTGEGHKGLYEILTTSWHAQLALNLAMLGSLTIVVAHHMYSMPPYPYLAIDYGTQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTQYNNLLDRVLRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPIFAQWIQNTHASAPSLTAPDATASTSLTWGGGDLVAVGNKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSISDQGVVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLLFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPAIQPRALSIVQGRAVGVAH
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PIMT_CELJU
Sequence: MTNLLLQGVGMTSLRTRERLIQRLRDQGVTNLRVLDIMLNTPRHLFLDEALAHRAYEDTALPIGHGQTLSQPYIVARMTELLLGAAGKLNKVLEVGTGSGYQTSLLAQLVPEVYTVERIKPLQDKARERLHQLGLRNIRYRHADGGFGWPDMGAYDGILSTAAPQVVPDELLKQLAPGGVLVIPVGGREQQLHLIIRDTEDTEKFVTQILEPVKFVPFLSGTAR
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_SHIBS
Sequence: MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILISNGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDVNLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK1_PARMW
Sequence: MSSAVLSPDRYINRELSWIAFNQRVLAQALDQRTPLLDQAKFSAIFSNNLDEFFMVRVASLKSQVEAGITTPSEDGKTPLEQLLTIRERLIPLLQQQQDHYRKQLRKKLLDHNVQLLDYSQLNKHQQQWVSDTFRHSVFPVLTPLAVDPAHPFPFVSNLSLNVAAVIHDPESGQRQFARVKVPQKNLPRFVSIPTELSESDPKPIHTAVPLEQVIAFNLDLLFPGMSVQGHYFFRVTRDADLELRDLEADDLMLALEQGLRKRRMGGEVVRLEVPNDMPEDVVEMLMNGLAVEEEDLYRIDGPLGLDDLFGLMALPLPKLKDKQHSGQTPTVLARTQQHLIDEGAIKPEEFESIFSVMRQQDILLHHPYDLFSTTVEEFINQAADDPQVMGIKMTLYRTSKDSPIIAALIRAAENGKQVMALVELKARFDEDNNIQWARQLERSGVHVVYGVLGLKTHTKIVLVVRKEQEKLRSYVHIGTGNYNSKTSKLYTDLGLLSTRPELGQDLVELFNYLTGFSKQQSFRRLLVAPVTLRKGMESLIRREIEHAREGRDGHIRAKMNSLVDPDIIALLYEAAAANVRVELIIRGMCSLYPGREGLSESISVVSIIGQFLEHSRIFWFGNGGSPEVYIGSADWMSRNLDRRVEAVTPVEDPNLRGRLERLLELYLKDNRGAWDMQSDGSFIQRQPEDGEDVRNSQVQLIKQWSQGVPQS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
What are the official names of this protein?
Polyphosphate kinase, ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 1 (PPK1) family.
Protein: Y930_HAEIN
Sequence: MARRKNHSIKIENNEKENQILVSLSIVALLGGCSEEQVQRDVYQSLDDCLADWKKIELCEADKNTESTQKTATTQQQGLGLNIRDNGNAESAVKNPAENNAQANQSENRAESTTKAESTDPSLGAAIAGGVIGYMAARAISSFLGPSYHPGNRAVTTPTGQVVQPQTNRSVGKPMLVKGNAGSMNSKPVSRGGFSSPNKTHRSSGG
What are the official names of this protein?
Uncharacterized protein HI_0930.
Protein: NT5D1_HUMAN
Sequence: MAQHFSLAACDVVGFDLDHTLCRYNLPESAPLIYNSFAQFLVKEKGYDKELLNVTPEDWDFCCKGLALDLEDGNFLKLANNGTVLRASHGTKMMTPEVLAEAYGKKEWKHFLSDTGMACRSGKYYFYDNYFDLPGALLCARVVDYLTKLNNGQKTFDFWKDIVAAIQHNYKMSAFKENCGIYFPEIKRDPGRYLHSCPESVKKWLRQLKNAGKILLLITSSHSDYCRLLCEYILGNDFTDLFDIVITNALKPGFFSHLPSQRPFRTLENDEEQEALPSLDKPGWYSQGNAVHLYELLKKMTGKPEPKVVYFGDSMHSDIFPARHYSNWETVLILEELRGDEGTRSQRPEESEPLEKKGKYEGPKAKPLNTSSKKWGSFFIDSVLGLENTEDSLVYTWSCKRISTYSTIAIPSIEAIAELPLDYKFTRFSSSNSKTAGYYPNPPLVLSSDETLISK
What are the official names of this protein?
5'-nucleotidase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the 5'(3')-deoxyribonucleotidase family.
Protein: FEOC_ECO7I
Sequence: MASLIQVRDLLALRGRMEAAQISQTLNTPQPMINAMLQQLESMGKAVRIQEEPDGCLSGNCKSCPEGKACLREWWALR
What is the function of this protein?
May function as a transcriptional regulator that controls feoABC expression.
What are the official names of this protein?
Probable [Fe-S]-dependent transcriptional repressor.
What is the protein family that this protein belongs to?
Belongs to the FeoC family.
Protein: RS14Z_GEOMG
Sequence: MAKTSMIIKAQRGSKFKVREYNRCPLCGRPRAYYRKFDMCRICLRKLASTGQIPGVIKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: NS1_PAVPK
Sequence: MAAGNTYSEEVLKATNWLQDNAQKEAFSYVFKTQKVNLNGKEIAWNNYNKDTTDAEMINLQRGAETSWDQATDMEWESEIDSLTKRQVLIFDSLVKKCLFEGILQKNLSPSDCYWFIQHEHGQDTGYHCHVLLGGKGLQQAMGKWFRKQLNNLWSRWLIMQCKVPLTPVERIKLRELAEDGEWVSLLTYTHKQTKKQYTKMTHFGNMIAYYFLNKKRKTTEREHGYYLSSDSGFMTNFLKEGERHLVSHLFTEANKPETVETTVTTAQEAKRGRIQTKKEVSIKCTIRDLVNKRCTSIEDWMMTDPDSYIEMMAQTGGENLIKNTLEITTLTLARTKTAYDLILEKAKPSMLPTFNISNTRTCKIFSMHNWNYIKVCHAITCVLNRQGGKRNTILFHGPASTGKSIIAQHIANLVGNVGCYNAANVNFPFNDCTNKNLIWIEEAGNFSNQVNQFKAICSGQTIRIDQKGKGSKQIEPTPVIMTTNEDITKVRIGCEERPEHTQPIRDRMLNINLTRKLPGDFGLLEETEWPLICAWLVKKGYQATMASYMHHWGNVPDWSEKWEEPKMQTPINTPTDSQISTSVKTSPADNNYAATPIQEDLDLALALEPWSEPTTPTFTNLHLTPTPPDSAIRTPSPTWSEIETDIRACFGENCAPTTNLE
What is the function of this protein?
Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication.  Also plays a role in viral packaging and transactivation of several promoters.  Binds site-specifically to 2-3 approximate tandem copies within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR).  Cooperatively binds Ori with host PIF and probably other host factors, which activate the nickase function of NS1.  Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis.  The helicase activity unwinds DNA in a 3'-5' direction on the longer strand.  Inhibits the host cell cycle during the G1/S transition, the S-phase, and the G2/M transition.  These arrests may provide essential cellular factors for viral DNA replication.  Promotes apoptosis in host cell.
What are the official names of this protein?
Initiator protein NS1, NS1, NCVP1, Non-capsid protein NS-1, Non-structural protein 1, Non-structural protein NS1.
What is the protein family that this protein belongs to?
Belongs to the parvoviruses initiator protein NS1 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: UGTP_STAAB
Sequence: MVTQNKKILIITGSFGNGHMQVTQSIVNQLNDMNLDHLSVIEHDLFMEAHPILTSICKKWYINSFKYFRNMYKGFYYSRPDKLDKCFYKYYGLNKLINLLIKEKPDLILLTFPTPVMSVLTEQFNINIPVATVMTDYRLHKNWITPYSTRYYVATKETKKDFIDVGIDPSTVKVTGIPIDNKFETPINQKQWLIDNNLDPDKQTILMSAGAFGVSKGFDTMITDILAKSANAQVVMICGKSKELKRSLTAKFKSNENVLILGYTKHMNEWMASSQLMITKPGGITITEGFARCIPMIFLNPAPGQELENALYFEEKGFGKIADTPEEAIKIVASLTNGNEQLTNMISTMEQDKIKYATQTICRDLLDLIGHSSQPQEIYGKVPLYARFFVK
What is the function of this protein?
Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids.  Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol).  Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA).
What are the official names of this protein?
Processive diacylglycerol beta-glucosyltransferase, Beta-diglucosyldiacylglycerol synthase, Beta-DGS, DGlcDAG synthase, Glc2-DAG synthase, Beta-gentiobiosyldiacylglycerol synthase, Beta-monoglucosyldiacylglycerol synthase, Beta-MGS, MGlcDAG synthase, Diglucosyl diacylglycerol synthase (1,6-linking), Glucosyl-beta-1,6-glucosyldiacylglycerol synthase, UDP glucosyltransferase, UDP-glucose:1,2-diacylglycerol-3-beta-D-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. UgtP subfamily.
What are the subcellular locations of this protein?
Cell membrane.
Protein: PRTS_SERMA
Sequence: MILNKRLKLAYCVFLGCYGLSIHSSLAAYQDPGRLGAPDSWKTAEFNRQWGLEAISAEFAYARGYTGKGITIGVIDNAILSHSEFSGKLTRLDNGSYNFSYDKQDNMSFGDHGTHVAGIAAAKRDGAGMHGVAFDADIIGTKLNDYGNRNGREELIQSAARVINNSWGIAPDIRRDAKGDIIWLPNGRPDYVAFVKSEVIAEMMRSKSSVEWGSEQPVPTGGHSAMSTLLRAARHGKLIVFSAGNYNNYNIPEAQKSLPYAFPDVLNNYLIVTNLSDENQLSVSSTSCGQTASYCVSAPGSDIYSTVGRLESNTGGAVNREAYNKGELSLNPGYGNKSGTSMAAPHVTGVAAVLMQRFPYMSADQISAVIKTTATDLGVAGIDNLFGWGRVNLRDAINGPKMFITKEDIPQEYYVPGSYSEKQFVVNIPGLGNIVEPGTPVERRCTSSECSFDSWSNDISGHGGLTKTGAGTLALLGNNTYRGDTWVKQGVLAIDGSVASNVYIENSGTLSGEGTVGAFRAARSGSVAPGNGIGTLHVLHDAIFDRGSQYNVEVADNGRSDKIAARRAFLNGGSVNVSLERSQNLLSQNEAQSLLGNKYTILTTTDGVTGRFENANPSYPFVKVALDYRGNDVGLGITRTDASFDSLASTENEKAVARAVETLNATEPVTETAKRSVAIPAAEEANLLQSDGGEAQAVNEEASIVAGHPIYESFLGFTSARELQQATRQLSGQIHADMASAQINESRYLRDTATERLRQAEGRRTATDIKADDNGAWAKLLGSWGHASGNDNATGYQTSTYGVLLGLDSELFGDGRLGMMTGYTRTSLDGGYQSDAHSDNYHLGLYGDKRFGALALRAGGTYTWHRIDTSRSVNYGAQSDREKAKYNARTGQLFIESGYDWTSDAVNLEPFANLAYTHYRNEEINEQGGAAALRGDKQSQSATASTLGLRADTEWQTDSVAIALRGELGWQHQYGKLERKTQLMFKRTDAAFDVNSVPVSRDGAILKAGVDVSINKNAVLSLGYGGQLSSNHQDNSVNAGLTWRF
What are the official names of this protein?
Extracellular serine protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMH_ACTSZ
Sequence: MSERNTFSHPEHTTVLLHEAVQGLALKEQGIYIDGTFGRGGHSRLILSRLSPNGRLIAVDRDPLAIVEAEKIQDPRFQIEHNSFSAIPEICAKYGLTGKVDGILLDLGVSSPQLDDAQRGFSFMKDGPLDMRMDTTKGLSASEWLAQVSERDLAWVLKTFGEERFAKRIAAAIVNYNKSAVEKNEEILNRTLQLAELISSAVPFKDKHKHPATRTFQAIRIFLNSELDELESVLQSALTVLAPQGRLSVISFHSLEDRMVKHFMRKQSRGEDIPKGLPLREEQIQRNRTLKTIGKAIQPSEREIAVNPRSRSAVLRIAEKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCPR_HUMAN
Sequence: MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS
What is the function of this protein?
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes.  It can also provide electron transfer to heme oxygenase and cytochrome B5.
What are the official names of this protein?
NADPH--cytochrome P450 reductase, CPR, P450R.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.