PharMolix/UniProtQA huggingface dataset:
Protein: VAC8_CHAGB
Sequence: MGICSSSCCGGKSRDALYENVLAENEREAVADLLQYLENRAETDFFSGEPLRALSTLVYSDNIDLQRSASLTFAEITERDVRAVDRDTLGPILFLLENSDIEVQRAASAALGNLAVNTDNKVLIVQLGGLQPLIKQMMSPNVEVQCNAVGCITNLATHEENKAKIARSGALGPLTRLAKSKDMRVQRNATGALLNMTHSDENRQQLVNAGAIPVLVQLLSSSDVDVQYYCTTALSNIAVDANNRRKLAETEQRLVQYLVNLTESSSPKVQCQAALALRNLASDEKYQLEIVQAHGLGPLLRLLRSSYLPLILSAVACIRNISIHPQNESPIIEAGFLKPLVDLLGSTDNEEIQCHAISTLRNLAASSDRNKSLVLEAGAVQKCKQLVLEVPVTVQSEMTAAIAVLALSDELKTHLLELGVFDVLIPLTMSPSVEVQGNSAAALGNLSSKVGDYSIFVQNWMEPRDGIHGYLNRFLASGDATFQHIAIWTLLQLLESEDKKLIGLIGKSDGVVDMIKQIANRQMMESDNEAEDDDEGEVVNLAQRCLELLGQGGSKSHIEG
What is the function of this protein?
Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
What are the official names of this protein?
Vacuolar protein 8.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Vacuole membrane; Lipid-anchor.
Protein: CRL_SALTY
Sequence: MTLPSGHPKSRLIKKFTALGPYIREGQCEDNRFFFDCLAVCVNVKPAPEKREFWGWWMELEAQEKRFTYRYQFGLFDKEGNWTVVPINETEVVERLEYTLREFHEKLRDLLISMELALEPSDDFNDEPVKLSA
What is the function of this protein?
Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes, such as the csgBAC operon encoding the subunits of curli proteins, and BcsA, involved in cellulose biosynthesis.
What are the official names of this protein?
Sigma factor-binding protein Crl.
What is the protein family that this protein belongs to?
Belongs to the Crl family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYV_XANOP
Sequence: MTTLASSYDPSSFESRLYAQWEAAGYFVPSDTGEPYTVLLPPPNVTGTLHMGHAFQQTLMDALVRYHRMRGYDTLWQVGTDHAGIATEMVVSRNLALEGKGETRDSLGREGFIAKVWEWKAASGDTIERQMRRLGTSSDWSRSTFTMDPQPSAAVNEAFVRWYEQGLIYRGQRLVNWDPVLKTAISDLEVENVEEDGFLWSIRYPLADGVTYEHIEHDADGNETLRETRDYLVVATTRPETMLGDTAVMVHPEDARYLTLHTARIVLPLTGRHVPVITDDYVDRAFGTGVVKVTPAHDFNDYQVGERHNLPLVNLFTADAKIIDPRKQYPDDESPFVNAGIDWRELDQIQRKRLGQHLAYKIPAQYIGLDRYDARKLVLSELEDLSILVETKPHKLQVPRGDRTGQVIEPYLTDQWFVKMDALAKRGLELVESGQIQFVPPNWINTYRHWMENIQDWCISRQLWWGHRIPAWFDDAGHCHVGHDEAEVRAKHGLGAEIALHQDSDVLETWFSSQLWPFSTLGWPDSQAMAERGFARYLPSSVLVTGFDIIFFWVARMIMATDSFTGQVPFRDVYITGLIRDAQGQKMSKSKGNVLDPLDIIDGISIEDLVAKRTNGLMQPRMAEKIEKATRKEFPDGIIAHGADALRFTIAALATHGRDIKFDLGRAEGYKNFCNKLWNATRFVLMNTEGARFTGVPQPRTEAEKWILARLDKVTAETHAHYANYRFDLLAQSLYEFAWNAFCDWFVELAKPALNNQDTDAAASTRHTLLYVLESLLRLLHPLTPFVTEELWQQVVPRLGITTATISLQRFPQVGDVDTSGYATAEADVEWLKSMVSALRRVRSELNVPPSKQVRLLLQADTADERPRVARFASQLSFLLKLERIDWLDAGQDTPPSAAAIVGELTLLVPLEGLVDMDAERMRLDKEIKRVKGEIGKCNGKLGNATFVQNAPAVVVDQERARLADWTTQLAGLREQRGKL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTRA_BACSU
Sequence: MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATIIIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDAHYAGVELEKLHEWIKEISADVKGGKKND
What is the function of this protein?
Negatively regulates ABC transporter complex ytrBCDEF that plays a role in acetoin utilization during stationary phase and sporulation.
What are the official names of this protein?
HTH-type transcriptional repressor YtrA.
Protein: RL3_PSYWF
Sequence: MAIGLVGKKCGMTRVFTETGASIPVTVVEVDANRITQIKTNDTDGYQAIQITTGERRDSRVTAAQKGHFAKAGVKAGRGVWEFRVTEEELEGREAGSEIAADLFEAGQLVDVTGQSKGKGFQGGVKRHNFSMQDATHGNSVSHRVLGSTGQNQSPGKVFKGKKMPGQMGNKRVTVQGLEVVSVDAEKGLLVIKGAIPGANGGDVIVRPSIKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: MECA_STAAT
Sequence: MRIERVDDTTVKLFITYSDIEARGFSREDLWTNRKRGEEFFWSMMDEINEEEDFVVEGPLWIQVHAFEKGVEVTISKSKNEDMMNMSDDDATDQFDEQVQELLAQTLEGEDQLEELFEQRTKEKEAQGSKRQKSSARKNTRTIIVKFNDLEDVINYAYHSNPITTEFEDLLYMVDGTYYYAVYFDSHVDQEVINDSYSQLLEFAYPTDRTEVYLNDYAKIIMSHNVTAQVRRYFPETTE
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
What are the official names of this protein?
Adapter protein MecA.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: PTH_RHOPB
Sequence: MRLLVGLGNPGAKYQGNRHNIGFMVLDEMARRHGFSPWRRRFQGETADGSIGGERVTLLKPLTYMNDSGRAVQDAASFFKLGLPDITVVHDEIELPAAKLRVKVGGGIAGHNGLRSISAHVGNDYRRVRIGVGHPGAKELVHGHVLNDFAKSERPWVEAMIEAIVEHAGLLVDGRDSTFQNKVHLALQAKGFLDNNDGSAA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYSS_DROME
Sequence: MKAFFALVLLAIAAPALAGRTLDRCSLAREMADLGVPRDQLDKWTCIAQHESDYRTWVVGPANSDGSNDYGIFQINDLYWCQADGRFSYNECGLSCNALLTDDITNSVRCAQKVLSQQGWSAWAVWHYCSGWLPSIDECF
What is the function of this protein?
Unlikely to play an active role in the humoral immune defense.  May have a function in the digestion of bacteria in the food.
What are the official names of this protein?
Lysozyme S, 1,4-beta-N-acetylmuramidase S.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
Protein: ADML_CANLF
Sequence: MKLVPVALLYLGSLAFLGADTARLDVASEFRKKWNKWAVSRGKRELRVSSSYPTGLAEVKAGPAQTLIRTQDVKGASRNPQTSGPDAARIRVKRYRQSMNNFQGPRSFGCRFGTCTVQKLAHQIYQFTDNDKDGVAPRSKISPQGYGRRRRRSLPEPGLRRTLLFPEPRPGGAPAPRAHQVLANLLKM
What is the function of this protein?
AM and PAMP are potent hypotensive and vasodilatator agents.
What are the official names of this protein?
Pro-adrenomedullin.
What is the protein family that this protein belongs to?
Belongs to the adrenomedullin family.
What are the subcellular locations of this protein?
Secreted.
Protein: URE1_AZOSB
Sequence: MAKITRRAYAEMFGPTTGDKLRLADTELIIEVEKDYTIYGEEVKFGGGKVIRDGMGQGQQLAAEIADTIITNALIVDAVAGIVKADVGLKDGRIWKIGKGGNPDIQPGVTIPVGAGTEVIAGEGMILTAGGIDSHIHWICPQQIDEALMSGVTTMLGGGTGPATGTYATTCTPGPWHIHRMLEAADAFPMNMGFFGKGNASLPGPLKEQVEAGVIGLKLHEDWGTTPAAIDNCLTVADEMDVQVAIHTDTLNESGFVETTLAAFKGRTIHTFHTEGAGGGHAPDIIKAVGQANVLPSSTNPTRPYTVNTIDEHLDMLMVCHHLDPAIAEDVAFAESRIRRETIAAEDILHDTGAFSMMSSDSQAMGRVGEVVIRTWQTAHKMKVQRGALAEDAGKGNDNFRIKRYIAKYTINPAITHGIAHVVGSIEEGKLADLVLWKPAFFGVKPSLILKGGMIAAAAMGDANASIPTPQPVHYRPMFGSYGKALKTSVTFVSQAALANPAVAALQLSKPLVAVQGCRTVQKADMVHNGATPAIDVDPETYVVRADGELLVCEPASELPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_LISMC
Sequence: MSKTVVRKNESLEDALRRFKRTVSKSGTLQESRKREFYEKPSVKRKKKSEAARKRKF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: RL11_PSEF5
Sequence: MAKKITAYIKLQVKAAQANPSPPVGPALGQHGVNIMEFCKAFNARTQGLEPGLPTPVIITVYSDRSFTFETKSTPASVLLKKAAGLTSGSARPNTVKVGTVTRAQLEEIAKTKNADLTAADMDAAVRTIAGSARSMGLNVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: FABH_STRMU
Sequence: MTFAKISQAAYYVPSQVVTNDDLSKIMDTSDEWITSRTGIRERRISQSEDTSDLASQVAKELLKKASLKAKEIDFIIVATITPDAMMPSTAACVQAKIGAVNAFAFDLTAACSGFIFALSAAEKMIKSGQYQKGLVIGAEVLSKIIDWSDRTTAVLFGDGAGGVLLEADSSEHFLFESIHSDGSRGESLTSGEHAVSSPFSQVDKKDNCFLKMDGRAIFDFAIRDVSKSISMLIRKSDMPVEAIDYFLLHQANIRILDKMAKKIGADREKFPANMMKYGNTSAASIPILLAECVENGTIELNGSHTVLLSGFGGGLTWGSLIVKI
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR12_NEOYE
Sequence: MPTIQQLVRSERRKIHKKTKSPALQSCPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGFEVTAYIPGVGHNIQEHSVVLIRGGRIKDLPGVRYHVVRGTLDAAGVKDRRKSRSKYGTKKPKS
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ENV_HV2BE
Sequence: MEPGRNQLFVVILLTSACLVYCSQYVTVFYGIPAWKNASIPLFCATKNRDTWGTIQCLPDNDDYQEIILNVTEAFDAWNNTVTEQAVEDVWHLFETSIKPCVKLTPLCVAMNCSRVQGNTTTPNPRTSSSTTSRPPTSAASIINETSNCIENNTCAGLGYEEMMQCEFNMKGLEQDKKRRYKDTWYLEDVVCDNTTAGTCYMRHCNTSIIKESCDKHYWDAMRFRYCAPPGFALLRCNDTNYSGFEPKCTKVVAASCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTIISLNKYYNLTMRCKRPGNKTVLPITLMSGLVFHSQPINTRPRQAWCRFGGRWREAMQEVKQTLVQHPRYKGINDTGKINFTKPGAGSDPEVAFMWTNCRGEFLYCNMTWFLNWVEDKNQTRRNYCHIKQIINTWHKVGKNVYLPPREGELACESTVTSIIANIDIDKNRTHTNITFSAEVAELYRLELGDYKLIEITPIGFAPTDQRRYSSTPVRNKRGVFVLGFLGFLATAGSAMGARSLTLSAQSRTLLAGIVQQQQQLLDVVKRQQEMLRLTVWGTKNLQARVTAIEKYLKHQAQLNSWGCAFRQVCHTTVPWVNDSLSPDWKNMTWQEWEKQVRYLEANISQSLEEAQIQQEKNMYELQKLNSWDILGNWFDLTSWVKYIQYGVHIVVGIIALRIAIYVVQLLSRFRKGYRPVFSSPPGYLQQIHIHKDRGQPANEGTEEDVGGDSGYDLWPWPINYVQFLIHLLTRLLIGLYNICRDLLSKNSPTRRLISQSLTAIRDWLRLKAAQLQYGCEWIQEAFQAFARTTRETLAGAWGWLWEAARRIGRGILAVPRRIRQGAELALL
What is the function of this protein?
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers.  Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells.  Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells.  This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: GLGC_GRABC
Sequence: MSGTSSIARSTMAYVLAGGRGSRLLELTDTRAKPAVYFGGKSRIIDFALSNAVNSGIRRIGVATQYKAHSLIRHMQRGWNFFRPERNEGFDILPASQRVSETQWYEGTADAVYQNLDIIAGYEPEYMIILAGDHIYKMDYEIMLHQHVERQADVTVGCIEVPREEATGFGVMQVDDTGRITAFLEKPSDPPGMPGQPDIALASMGIYVFKTKFLFDVLRRDAADPDSKHDFGGDIIPDLVENGTAIAHRFSDSCVRSSKTAEAYWRDVGTLDSYWQANLDLTNVVPTLDLYDSGWPIWTYNEISPPAKFVYDDVGRRGMAVDSLVAGGCIVSGASLSRSLISTGCRVHSFSQLHGTVVLPYADIARSARLRNTVVDRGVRIPEGLVVGEDPELDAKRFRRTEKGICLITQPMIDRLG
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: SERC_PECAS
Sequence: MTQIFNFSAGPAMLPVEVLRRAEQELCNWNGLGTSVMEISHRSKEFMQVAAESEQDLRDLLKIPSNYKVLFCHGGARAQFAAVPLNLLGERSTADYIDGGYWAHSAINEAEKYCTPNVIDVKTRIDDLRGIKPMREWKLSDDAAFVHYCPNETIDGIAIEEEPDFGDKIVVADYSSSILSRRIDVSRYGVIYAGAQKNIGPAGLTLVIVREDLLGKARRELPSILDYQVLADNDSMFNTPPTFAWYLSGMVFKWLKEHGGLAEMEKRNQEKADLLYSAIDGNDFYRNDVALANRSRMNVPFLLADSALDKVFLEESVAAGLHALKGHRVVGGMRASIYNAMPLEGVKALTEFMADFARRHG
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_LATSS
Sequence: MATETAIFAGGCFWCMVHPFDQQPGILKVVSGYTGGHVANPTYEQVCSHTTGHTEAVEITFDPAVISYAELVEIYWRQTDPTDAMGQFQDRGDSYRPVIFVNSDQQRSIAEASKEKLIASGRFNEPIVTQIEAAKPFYPAEDYHQDFYKKEPWRAELGEVKRKAFIREKWSD
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: ARMC6_PONAB
Sequence: MSERCRCKYSSGASIDYMPTSTQAKMVSKRIAQETFDAAVRENIEEFAMGPDEAVKEAVEQFESQGVDLSNIVKTAPKVSADGSQEPTHDILQTLSDLQESVASSRPQEVSAYLTRFCDQCKQDKACRFLAAQKGAYPIIFTAWKLATAGDQGLLLQSLNALSVLTDGQPDLLDTQGLQLLVATLTRNADEADLTCSGIRCVRHACLKHEQNRQDLVKAGVLPLLTGAITHHGHHADVVREACCALRVMTFDDDIRVPFGHAHNHAKMIVQENKGLKVLIEATKAFLDNPGILSELCGTLSRLAIRNEFCQEVVDLGGLSILVSLLADCNDHQMGDQSSVQELVKQVLSILRAIAGNDDVKDAIVRAGGTESIVAAMTQHLTSPQVCEQSCAALCFLALRKPDNSRIIVEGGGAVAALQAMKAHPQKAGVQKQACMLIRNLVAHSQAFSKPILDLGAEALIMQARSAHRDCEDVAKAALRDLGCHVELRELWTGQRGNLAP
What are the official names of this protein?
Armadillo repeat-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the ARMC6 family.
Protein: RIOK1_HUMAN
Sequence: MDYRRLLMSRVVPGQFDDADSSDSENRDLKTVKEKDDILFEDLQDNVNENGEGEIEDEEEEGYDDDDDDWDWDEGVGKLAKGYVWNGGSNPQANRQTSDSSSAKMSTPADKVLRKFENKINLDKLNVTDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYIPRTLNEVKNYERDMDIIMKLKEEDMAMNAQQDNILYQTVTGLKKDLSGVQKVPALLENQVEERTCSDSEDIGSSECSDTDSEEQGDHARPKKHTTDPDIDKKERKKMVKEAQREKRKNKIPKHVKKRKEKTAKTKKGK
What is the function of this protein?
Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit.  Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA.  Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790).  The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity).  Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity).  The catalytic activity regulates its dynamic association with the 40S subunit (By similarity).  In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503).
What are the official names of this protein?
Serine/threonine-protein kinase RIO1, RIO kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: VWC2L_MOUSE
Sequence: MALHIHEACILLLVIPGLVTSAAISHEDYPADEGDQASSNDNLIFDDYRGKGCVDDSGFVYKLGERFFPGHSNCPCVCALDGPVCDQPECPKIHPKCTKVEHNGCCPECKEVKNFCEYHGKNYKILEEFKPSPCEWCRCEPSNEVHCVVADCAVPECVNPIYEPEQCCPVCKNGPNCFAGTTIIPAGIEVKVDDCNICHCHNGDWWKPAQCSKRECQGKQTV
What is the function of this protein?
May play a role in neurogenesis.  May promote matrix mineralization (PubMed:22209847), but has been shown to weakly, but significantly inhibit BMP2 and BMP6 activity in a preosteoblastic cell line (PubMed:19852960).
What are the official names of this protein?
von Willebrand factor C domain-containing protein 2-like, Brorin-like.
What are the subcellular locations of this protein?
Secreted. Synapse.
Protein: CA16_CONQU
Sequence: FDGRNAAASDKASELMALAVRGCCSNPTCAGNNGNICG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
What are the official names of this protein?
Alpha-conotoxin-like Qc1.6.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_NEIMF
Sequence: MALTVEQKAQIVKDFQRKEGDTGSSEVQVALLTFRINDLTPHFKANPKDHHSRRGLLKMVSQRRRLLAYLRRTQPDTYRALITRLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: DDL_PECCP
Sequence: MTEKVAVLLGGTSAEREVSLLSGQAVLAGLKEAGINAHAVDTRDVSVTTLKEEGFTKIFIALHGRGGEDGTLQGVLEFLGLPYTGSGVMASALTMDKLRTKQVWQAVGLPVSPYVALDRRQYSEMAANALLATFTHLGLPLIVKPSREGSSVGMSKVNTLSELPAALEEAFRHDDDILVEKWLSGPEYTVAILGDEVLPSIRIQPAGTFYDYEAKYLSDDTQYFCPSGLSDEKEQELAGLAMAAYRAVGCSGWGRVDFMLDSDGAFYLLEVNTSPGMTSHSLVPMAAHQRGLTFSQLVVKILELAG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_I34A1
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMKKEEMGITTHFQRKRRVRDNMTKKMITQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYMTRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIEGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESMNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGVLEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: AROQ_BRUA2
Sequence: MTKTVFVLNGPNLNLLGKREPGIYGVATLDDIEASCKREAGQLELQIDFRQSNHEGDLVSWIQEAGEKNAYVLINPAAYSHTSVAIHDAIRSARVTVVEVHLSNIHAREAFRHHSHVSAVAKGVICGFGAEGYLLGLRALAAIAKEEEKNGQSIKGA
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: KDSA_BARQU
Sequence: MFQPNTIVKVGNIVFSNETPFSLIVGPCQMESRDHAFEMAGRIKTITDQIGIGFVYKSSYDKANRTSLGAARGIGLEKAMAIFSDIKKEFGCPVLTDVHTEEQCAAVGSVVDVLQIPAFLCRQTDLLVAAAKTGRVINIKKGQFLAPWDMENVLKKVTQSGNPHVMLCERGTSFGYNRLISDMRSLPILRSFGAPVIFDATHSVQEPGGQGDSSGGQRQFVEVLARAAVSVGVAGIFLETHQDPDNAPSDGPNMVKIDHLQRLLETLMEFDYLSKKVN
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXA_HELPY
Sequence: MAKKKIAISCGDIQGVGLELILKSHKEVSALCEPLYLTDGELLERANQLLHNAYETKVLNALAIDAPLPLLNSSTIGKVSAQSGAYSFESFKKACELADSKEVDGICTLPINKLAWQQAQIPFVGHTDFLKQRYKDHQIIMMLGCSKLFVGLFSDHVPLGAVSQLIQVGALVKFLLAFQKSTQAKIVQVCGFNPHAGEEGLFGEEDERILKAIQKSNQTLGFECFLGPLPADSAFAPNKRKITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRTSTDHGTAFDIAYQNKANNKSYLNAIKYLA
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.