PharMolix/UniProtQA huggingface dataset:
Protein: PDXT_CLOB8
Sequence: MKVGVLSFQGGVIEHLNQIRALGHTGVEVKKEKDLDDIDAIILPGGESTTIGKLLKITGLIKSLKEKIESGLPTWGTCAGMILLANEVEGQEEKYLQLMDIKVKRNAFGTQIDSFKTHKVIEKISKDEMELVFIRAPYITEVKDNVRILCKVDDKIVAARQDNIIVTSFHPELTNDVTFLNYFLKSKWMK
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: SL9A4_RAT
Sequence: MGPAMLRAFSSWKWLLLLMVLTCLEASSYVNESSSPTGQQTPDARFAASSSDPDERISVFELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGSIIFGTHHKSPPVMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGISVVLYNILIAFTKMHKFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCQIWRAISVFTLFYVSNQFRTFPFSIKDQLIIFYSGVRGAGSFSLAFLLPLTLFPRKKLFVTATLVVTYFTVFFQGITIGPLVRYLDVRKTNKKESINEELHIRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHRYLRKILIRRNQPKSSIVSLYKKLEMKQAIEMAETGLLSSVASPTPYQSERIQGIKRLSPEDVESMRDILTRNMYQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESLRKGQSLPWVKPAGTKNFRYLSFPYSNPQPARRGARAAESTGNPCCWLLHFLLCRAMVEKIWGPGGQETQPRLLCRNLN
What is the function of this protein?
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions.  Major proton extruding system driven by the inward sodium ion chemical gradient.  Plays an important role in signal transduction.  May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage.  Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive.  Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner.  Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner.  Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange.  In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion.  In apical cell membrane may be involved in mediating sodium absorption.  Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation.
What are the official names of this protein?
Sodium/hydrogen exchanger 4, Na(+)/H(+) exchanger 4, NHE-4, Solute carrier family 9 member 4.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Zymogen granule membrane; Multi-pass membrane protein. Note=Enrichment at apical or basolateral membrane may be tissue-dependent.
Protein: FETUB_HUMAN
Sequence: MGLLLPLALCILVLCCGAMSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPTNLPKVEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPKEKARTAECPGPAQNASPLVLPP
What is the function of this protein?
Protease inhibitor required for egg fertilization.  Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).
What are the official names of this protein?
Fetuin-B, 16G2, Fetuin-like protein IRL685, Gugu.
What is the protein family that this protein belongs to?
Belongs to the fetuin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYL_PSEAB
Sequence: MHEQYQPLEIETQAQNYWKEHQSFLVRELPDKEKFYCLSMFPYPSGKLHMGHVRNYTIGDVISRYHRMQGRNVLQPMGWDAFGMPAENAAMKNNVAPAAWTYDNIAYMKSQLDSLGLAIDWSREVTTCKPDYYRWEQWLFTRLFEKGVIYRKNGTVNWDPVDQTVLANEQVIDGRGWRSGALIEKREIPMYYFKITAYAEELLESLDNLPGWPEQVKTMQRNWIGKSRGMEIGFPYDQASIGHAGQLKVFTTRPDTLMGATYVAVAAEHPLATQAAQNDPQLQAFIDECKRGGVAEADIATQEKKGMATSLFVEHPLTGDKLPVWVANYVLMNYGEGAVMAVPGHDERDFEFANKYGLPIRQVIAKVEGDDDFESSVWKEWYGAKDESVLTVNSGKYDNLGYQAAFDAIGADLEAKGLGQARTQFRLRDWGISRQRYWGCPIPIIHCEACGDVPVPADQLPVVLPEDVVPDGSGSPLAKMPEFYECSCPKCGQPAKRETDTMDTFVESSWYFARYACPQFEGGMLDRKAADYWLPVDQYIGGIEHAILHLLYARFFHKLMRDEGLVGSDEPFKNLLTQGMVVADTYYRTTANGGKDWFNPADVEVERDAKAKVVGARLKSDGQPVEIGGTEKMSKSKNNGVDPQSMIDQYGADTCRLFMMFASPPDMSLEWSDAGVEGANRFLRRVWRLAHAHVSAGLPGALDVAALDDAQKQVRRAIHLAIRQASQDVGQHHKFNTAIAAVMTLMNVLEKAPNQDAQDRALIQEGLETVVLLLAPITPHICHVLWGQLGHAEAVIDARWPSVDESALVQDTLQLVVQVNGKLRGHIDVAASASREDVEAAARANENVLRFTEGLSIRKVIVVPGKLVNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_THERP
Sequence: MDERLWEWDFEVAEAIACEERRQSRTIELIASENFTSPAVLAAVGSVLTNKYAEGYPGRRYYGGCECVDRVEELAIQRAKQLFGAPHVNVQPHSGAQANMAAYFAVLQPGDRILGMSLQHGGHLTHGAKVNLSGRWFEVAFYGVDPETERIDYDAVWHIAREIRPKLIISGASAYPRVIDFARLREIADDVGAILMADIAHIAGLVAVGLHPSPIGVAQLVTTTTHKTLRGSRGGMIMCDAEFAEAVDKAVFPGTQGGPLMHVIAGKAVALGEALRPTFRTYIERVLENARVLAETLQAEGFRLVSGGTDNHLLLVDLRSHGLSGRKAERVLDEVGITVNKNTIPNDPKPPTQASGIRLGTPAMTTRGFGPDEMRLTARWIADVLRAPDDESVKARVRAEVAELVSRFPVPGVTIEARTGVDDGTV
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIN_NICSU
Sequence: MNHHLIITPIFHLQIMLPVATLKRPPPPAATCSIYSFSRGTPSLVSKARLSTAAVGGMKNEPSPNHYSDISSSDLNLTRRSGNYGPTMWDFEYIQSIHNDYTEKKYMNRLNKLKEEMKKMIMAEGSQELEKLELIDNLQRLGVSYHFKHEIMQILSSIKQHSTPADSLYATALKFRLFREYGFHISQEIFGGLSETHTEDTKGMLYLYEASFLATEGESELEKARNWTEKHLREYLENKNDDQNVAELVHHALELPLHWRMLRIEARWFINFYKKKQDMIPLLLELAILDFNIVQAAHIEDLKYVARWWKETCLAENLPFARDRLVENFFWTIGVNFLPQYGYFRRIETKVNALVTTIDDVYDVFGTMDELQCFTHAFQRWNIDELDNLPDNMKMCYFALDNFINEVAGDAFEEHRVPILSYLRNAWTDLCKAYLREAKWYFSKYIPTMEEYMDNAWISISAPVILVHAYFLVANPVNKEVLHYLENYHDIIRWSALILRLANDLGTSSEELKRGDVPKSIQCYMNEKKVSEEEARQHIRLLISETWKKLNEAHNVAAHPFPKMFVKCAMNLARMAQCMYQHGDGHGHGDLNSETTNHIMALLFESIPPA
What is the function of this protein?
Monoterpene synthase involved in the biosynthesis of monoterpene natural products of the 'cineole cassette', volatile compounds present in floral scent (PubMed:17611797).  Catalyzes the conversion of (2E)-geranyl diphosphate (GPP) into 1,8-cineole and, as minor products, limonene, sabinene, (E)-beta-ocimene, beta-myrcene, alpha-pinene and alpha-terpineol (PubMed:17611797).
What are the official names of this protein?
1,8-cineol synthase, chloroplastic, (E)-beta-ocimene synthase, Alpha-pinene synthase, Alpha-terpineol synthase, Beta-myrcene synthase, Limonene synthase, Sabinene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL4_STRT1
Sequence: MANVKLFDQTGKEVSTVELNDAIFGIEPNESVVFDVVISQRASLRQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLPQKVRRLALKSVYSAKVAEDKFVAVEALSFAAPKTAEFANVLSALSIDSKVLVIVEEGNKFAELSARNLANVTVATPATASVLDIVNADKLLVTKEAISSIEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RL13_CHLAB
Sequence: MEKRKDTKTTIAKASEAQNKSWYVIDAAGKTLGRLSSEVAKILRGKHKVTYTPHVAMGDGVIVINAEKVHLTGAKKGQKIYRYYTGYISGMREVAFENMIAKKPSYIIEHAIKGMMPKTRLGKRQVKSLRILKGDYYQEFKSQKPIVLDV
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: CYC_THEPA
Sequence: MAKPEPDVVIPEGDSSKGAKLFKSKCAQCHTINKGGSVKQGPNLYGFYGRKSGASDYAYSDANKNSGIVWSDKHLFVYLVNPKQYIPGTKMVFAGLKKEQDRADLIAYLKEASSK
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: TRUA_SALA4
Sequence: MSGQQSSPVYKIALGIEYDGSKYYGWQRQNEVRSVQEKLEKALSQVANEPINVFCAGRTDAGVHGTGQVVHFETTALRKDAAWTLGVNANLPGDIAVRWVKTVPDDFHARFSATARRYRYIIYNHRLRPAVLAKGVTHYYEPLDAERMHRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRHGPYVVVDIKANAFVHHMVRNIVGSLLEVGAHNQPESWIAELLAARDRTLAAATAKAEGLYLVAVDYPDRFDLPKPPMGPLFLAD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GCSH_POLNS
Sequence: MNSQDTFKFAETHEWADQEDDGLIWVGISNHAQEALGDVMFFQAPKLDQQVKQGEAIAVIESVKAASDIHAPVSGEIVALNEEVDASPELVNEEPYGIWLFKINRPLMRFLYPTRCALEFRKILCRPWRLIIKLKWGRAQLTSECGLLC
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: DPO4_SHESR
Sequence: MRKIIHIDMDCYFAAVEMRDFPEYRGKPLAVGGSRVQRGVISTCNYEARKFGVRSAMATGYALKLCPDLILVPGRMQVYKEVSQQIRAIFSRYTELIEPLSLDEAYLDVSDCKLFKGSATLIAEAIRRDILAETGLTASAGVAPIKFLAKVASDLNKPNGQCVIPPDEVPEFVKSLSLRKIPGVGKVTAEKLSSLGLNTCADVQAYPKQELIARFGKFGAVLVERAHGIDDRGISVSRERKSVGVETTLAQDIYTLEQCQQVMPGLIQELSSRLGRSAKGRQIHKQVVKLKFNDFKQTTIEHRSDEVSVVMFYELLSQAMARQEGRGIRLLGVSVGLAESKDTLAPLMVRETKQLDFVF
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_SALNS
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: YOZG_BACSU
Sequence: MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIRLSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YozG.
Protein: ADDA_DESHY
Sequence: MNNPKWTPAQQAAIDLKGQLLVAAAAGSGKTAVLVQRLFKQITDVDEQVDVDRFLVVTFTKAAAAEMRERIGKALDEALFGAAEPAQVEHLLQQRALLYRASITTLHSFCMELIRQYFYLIELDPAFRVADEAEADLLRQDTLEDLFEAYYGEETPAFQSLVDAFGTDRDDQPLMASILRLHEFAMSQVHPGEWLEHLPAAYDWHSLDDLMESPWGQVVRQGVRDKVEEGLILLERAYRLAELPGGPVHYLPVLEDDQSRLGFLREMAEKGTWSDIETAFKSAAAFPGLPRGSKKNLPDSLIDEENSKRLREESKKARDEAKKKLEEIKNTVFSVPLTDQLPFLNKMGELVGTLAQVTQHFAREYQKAKRQRNCVDFSDLEHYALQLLAKDKQPTEIALKLQAYYAEVLVDEYQDINPVQERILQLVSRQEEGKANLFMVGDVKQSIYRFRMADPGLFLRKYGEFPHYQEGGGAAPNLVIDLNQNFRSRPEVIQGINYLFYQIMTEGAGEIIYDEQAALRPGAKFVSDGELRTAEGPIEVHLFDPKAIDLSLGQKRGAEDAATGADSPAKGEGEEFEQNREPESGDDESSLEEAETARIEARLVAARIQKMVLEREFQIHDKELGDYRPVQYADIVILMRSLASVASVYAEEFQKAGIPVYAETNSGYFGTNEVDTVLSLLKIIDNPRLDIPFAAVLRSPLVGMNGTELGKLRSLLPQGDFYETLVLTFWAGDAHRQEEGHEFYSEIREILGKHWESLPQLEVKVRHILETSPEIKEKVDAFFPKLQEWRHRSRRTSLADLLWHLYEDTGYLAYVGTLPAGAQRQANLRVLYDRACRYEATNYRGLFRFLRFLEKFQSQGKDLGNASIVGEKENVVRFITVHSSKGLEFPVVFIAGLGKKFNTRSLSSQLLLHSHLGVGIPLIDIENQVRYPSVIQYAVKERLWQEALAEELRILYVALTRGKERLFLFGHQHKLAEAINKWRSLALSCPDTAFPDGQLRGAKTYLDWLGPALVRHPEDLFKLGSFPTASELPDSSSQWKVILHDQIAGKGPVQEATSSQDEIILPDQETLGEREASEETEIPGETEASGKTEIPGETKNSEETKTSEDKKNLEAQTPETADLDTKNLQEEVFRQLNWQYPYPEGVNQSAKTSVSELKRQSLWYMDNEYSSPSSSSSSSPSALSAPSFLRPQFIVSRKELTPAERGTAVHAAIQHLPLALWRDTWEELAQEVRESMLQEHIDSLIRREILSAEQGGAVSVSQLKNLLDSTSGKRLWEAEEVRREVPFTLSLRLRAQKEPVLVQGIIDAVLLSHQEHEAQVMDFKTDNLAGVPDPELVLTQRYGLQLGLYALAVERLLKVPVRECIIYATSLNREFVMQREAVQAALESVVIV
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: SYP_SALG2
Sequence: MRTSQYLLSTLKETPADAEVISHQLMLRAGMIRKLASGLYTWLPTGLRVLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGRWEQYGPELLRFVDRGERPFVLGPTHEEVITDLVRNELSSYKQLPLNFFQIQTKFRDEVRPRFGVMRSREFLMKDAYSFHTSQESLQETYDAMYAAYSRIFSRMGLDFRAVQADTGSIGGNASHEFQVLAQSGEDDIVFSDVSDYAANIELAEAIAPQTPRAAATQEMTLVDTPNAKTIAELVEQFNLPIEKTVKTLLVKAVKDSKSPLVALLVRGDHELNEVKAEKLPHVASPLTFATEEEIRAVINAGPGSLGPVNMPIPVIIDRTVAAMSDFAAGANIDGKHYFGINWDRDVATPVVADIRNVVAGDPSPDGQGTLLIKRGIEVGHIFQLGTKYSEALKASVQGEDGRNQILTMGCYGIGVTRVVAAAIEQNFDERGIVWPDAIAPFQVAILPMNMHKSFRVQELAEKLYSELRAQGIEVLMDDRKERPGVMFADMELIGIPHTIVIGDRNLDNDDIEYKYRRSGEKSLIKTGDIVDYLVKAIKG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFTE_MYCUA
Sequence: MNSSYHRRVPVLGELGTSTSSQLPSTWPSILIPLGSTEQHGPHLPLDTDTRIATAVGRAVATRMHGRLTQCQPGWLLAPPIAYGASGEHQSFAGTISIGAEALRVLLLEYGRSAACWADRLVFVNGHGGNVEALRGAVRQLRAEGRDAGWSACGSAGGDAHAGHTETSVLLHISPEVVLTDRLSAGNAAPLAELLPSLRRGGVAAVSPIGVLGDPTTATAVEGRRIFAEMVDDCVSRIARWTPGPDGMLT
What is the function of this protein?
Peptidase involved in the biosynthesis of the enzyme cofactor mycofactocin (MFT).  Catalyzes cleavage of the MftC-modified MftA peptide to liberate its final two residues, which consist of a cross-linked valine-decarboxylated tyrosine dipeptide (named 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one or ADHP).
What are the official names of this protein?
Mycofactocin precursor peptide peptidase.
What is the protein family that this protein belongs to?
Belongs to the creatininase superfamily.
Protein: NU1M_DICDI
Sequence: MENMLYIIIEGGLKSLIVIIGLLIGVAFATLLERKVMAAMQKRRGPNVVGFVGLLQPLADGLKLVLKETIIPIVADKLIYAIAPILTFTISIVLWSVIAVGVQSVFASINSGVIFILAISSIGVYGIILAGWASNSKYAFLGGLRSAAQMVSYEVALGLIILSIITYAGTVNLQEIMENQEKVWFIIPLLPGFLLAFISALTETNRPPFDLPEAEAELVSGYNVEYSSTGFALFFLGEYANIILMSVLLSVFFLGGIVSNKILGAMKGVGMLCSFIWVRATLPRYRYDQLMYLGWKSLLPFALLIYIGVISMVLIIK
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PCRB_EXIS2
Sequence: MLLPYNEWRHVFKLDPAKEIEEAALQAIATSGTDAIIVGGTDDITLDATLDLLMRLRRYPVAVALEVSELEAATMGFDAYLTPSVLNSGTLEHVIDKQVEALEEVGHMLAHQDLVGEGYIVLNADAKVARVTQAKLLNDDQVVAYAQLADSVFRMPIIYLEYSGMYGDPSLVASVKRVLKQGRLFYGGGIDSIERAQEMLTHADTIVVGNIIYDNLEAALATVAATR
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
Protein: SFSA_RHIME
Sequence: MNFPRPLVPATLVQRYKRFLFDAILADGTAITGSCPNTGSMRGLTIPGSPIWLSEHDSPTRKYRHMLEIVEADGTLVGINTGLPNRIAEEAIMAGQVGNLHTYGTLRREQRYGRNSRIDILLSDAEKGLAYVEVKNVHFSRVRGLAEFPDSPTQRGAKHLEELGDMVEAGHRAIMLYLIQRGDCSRFRICRELDPVYARAFERASARGVEAYAVKCAVSPGQIVAAGPIVVDEPVPAVL
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: RUVB_BACFR
Sequence: MEEDFNIRDHQLTSRERDFENALRPLSFEDFNGQDKVVDNLRIFVKAARLRAEALDHVLLHGPPGLGKTTLSNIIANELGVGFKVTSGPVLDKPGDLAGVLTSLEPNDVLFIDEIHRLSPVVEEYLYSAMEDYRIDIMIDKGPSARSIQIDLNPFTLVGATTRSGLLTAPLRARFGINLHLEYYDDDILSNIISRSAGILDVPCSSQAAGEIASRSRGTPRIANALLRRVRDFAQVKGSGSIDTEIANYALEALNIDKYGLDEIDNKILCTIIDKFKGGPVGLTTIATALGEDAGTIEEVYEPFLIKEGFLKRTPRGREVTELAYKHLGRSLYNSQKTLFND
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ASB11_BOVIN
Sequence: MEDGSVSYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIFGEISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNHGQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ
What is the function of this protein?
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
What are the official names of this protein?
Ankyrin repeat and SOCS box protein 11, ASB-11.
What is the protein family that this protein belongs to?
Belongs to the ankyrin SOCS box (ASB) family.
Protein: LPSE_RHIME
Sequence: MKVTHFHFGKDGGAERFFVHLVNALAERGVEQTAIIRPGRGWRRDIEGAAKIRESHFRNLSLDRILLPLKVKHMARREKPDVLMAWAPRASELMPNYKGAFKISRLGDYPTRLSYFRNTDCIVCNTPGIAERVSDLGWKREIRVISNFTGTGRVVAVDRAKLDTPADAPVVMSMGRFVERKGFHTLIEAVARLPGVYLWLLGDGEERDNLHKLATDLGVSGRVRFAGWQDDTRPFLAAVDVFVMSSSHEPLGNVILESWAQGTPVVSTRSEGPQWFMRDGENGLMVDIGDAEGFARAIEQIVADNSLRTRLAERGHETLVGQFSREAITDAYLQLLASKP
What are the official names of this protein?
Lipopolysaccharide core biosynthesis glycosyltransferase LpsE.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: KDPC_CAUVC
Sequence: MLSHLRPALVSMGLFTVLLGLAYPLAVTGVAQAAFPNQANGSLIRDADGKVVGSALIGQVFAKPEYFHGRPSAAGAGYDASASSGSNMGPLNETLIARLKTDAAALRAENPGVAIPADAVTTSGSGLDPDISPANARFQAPRVAGARGVPEKDVTALIDAQVQQPLLGFIGQPRVNVLALNRALDARYPPLASQKDG
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.