PharMolix/UniProtQA huggingface dataset:
Protein: OXYS_STRR1
Sequence: MRYDVVIAGAGPTGLMLACELRLAGARTLVLERLAEPVDFSKALGVHARTVELLDMRGLGEGFQAEAPKLRGGNFASLGVPLDFSSFDTRHPYALFVPQVRTEELLTGRALELGAELRRGHAVTALEQDADGVTVSVTGPEGPYEVECAYLVGCDGGGSTVRKLLGIDFPGQDPHMFAVIADARFREELPHGEGMGPMRPYGVMRHDLRAWFAAFPLEPDVYRATVAFFDRPYADRRAPVTEEDVRAALTEVAGSDFGMHDVRWLSRLTDTSRQAERYRDGRVLLAGDACHIHLPAGGQGLNLGFQDAVNLGWKLGATIAGTAPPELLDTYEAERRPIAAGVLRNTRAQAVLIDPDPRYEGLRELMIELLHVPETNRYLAGLISALDVRYPMAGEHPLLGRRVPDLPLVTEDGTRQLSTYFHAARGVLLTLGCDQPLADEAAAWKDRVDLVAAEGVADPGSAVDGLTALLVRPDGYICWTAAPETGTDGLTDALRTWFGPPAM
What is the function of this protein?
Involved in the biosynthesis of the antibiotics oxytetracycline and tetracycline.  OxyS starts by catalyzing the stereospecific hydroxylation of anhydrotetracycline at C(6) position to yield 5a,11a-dehydrotetracycline (12-dehydrotetracycline).  If the released product is captured by OxyR, it is reduced to tetracycline.  However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C(5), producing 5a,11a-dehydrooxytetracycline, which, following the action of OxyR becomes oxytetracycline.
What are the official names of this protein?
12-dehydrotetracycline 5-monooxygenase/anhydrotetracycline 6-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the PheA/TfdB FAD monooxygenase family.
Protein: TMC8_MOUSE
Sequence: MFRQWSVQSGPAPRRPESQAASEELWEQEVERLCASRTPVRMLPYAMADKRFIRELREPEGVKTTFWQRWHRPRRVARQHLREAEQRLARGFGLWEGALYEIGGLFGTGIQSYFTFLRFLLLLNLLTMLLTACFVLLPLVWLRPPELGPALKLRLQCSSSPLPQSDIPRFHNPLWNILTGRAFNNTYLFYGAYRAGPESSSEYSIRLAYLLSPMVCLLLCFCGILQRMAEGLPQQTLLGQRYRTPLSAKVFSSWDFCIRVWEAATIKKHEISNELKMELEEGRRVELAQQQTRAQKACRLLTYLRTNILIVLLVVGAISAIFWATKYSQDNKEESLFLVLQYLPPGVISLVNFLGPQLFTVLIQLENYPPGTEVNLTLIWCVVLKLASLGMFSFSLGQTVLCIGRNKTSCESYGYNACDYQCWENSVGEELYKLIIFNFLLTVAFAFLVSLPRRLLVERFSGWFWTWLDREEFLVPKNVLDIVAAQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLRNSRASPRRFRASSSTFFFHLVLLLGLLLAAVPLAYVISSTHSSWDCGLFTNYSAPWQVVPELVALQLPLPSQRALRYLSSHAFSFPLLILLSIVLTVCISQSRANARAIQGLRKQLVWQVQEKWHLVDDLSRLLPELSPEPGSPHSRASRPRSFCPGFPCPGSPGPRTPRLAPSNRLSSSSLGAPSASVPASRFHFPSRTEL
What is the function of this protein?
Probable ion channel.
What are the official names of this protein?
Transmembrane channel-like protein 8, Epidermodysplasia verruciformis protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the TMC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RNPH_STRGG
Sequence: MSRIDGRTPEQLRPVTIERGWSKHAEGSVLISFGDTKVFCTASVTEGVPRWRKGSGEGWVTAEYSMLPRSTNTRGDREAVRGKIGGRTHEISRLIGRSLRAVIDCKALGENTIVLDCDVLQADGGTRTAAITGAYVALADAVAWAQGKKIVKAGRKPLTDTVAAISVGIVDGTPLLDLCYEEDVRAETDMNVVCTGDGRFVEVQGTAEGAPFDRKELGALLDLATAGCVDLAALQRDALVRTQDA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: SYL_LEPIC
Sequence: MQYPFQEVESFWQKFWEEHKSFQTNIRSSKPKFYCLDMFPYPSGAGLHVGHPEGYTATDILSRFKRMKGFEVLHPMGWDAFGLPAERYAMQTGIHPAITTKDNIDNFRRQIQMIGLSYDWSRELSTTDPDYYKFTQWIFIQLYQSWFNPELKKAESINELIRRFSNQGSNGLDYRQFNSEEWKNFSPVEKEKILSDFRLVYQAEIPVNWCEALGTVLANEEVEEWVGKGYEVVRKPMRQYMMRITAYADRLLEDLELVEWPPSTLEMQKNWIGKSEGLEITFPFLKPLQSGLEGIRIFTTRPDTIFGVTYMVVAPEHPIVSEITTPEQKQKVEEYQKTSSLKSDLDRMELNKEKTGVFTGTFVFNPADPSQKIPVWISDYVLYGYGTGAIMAVPAHDQRDFEFARTFGLKIIPVIEGEISEAAFDSKTSTCINSSSSEISINGLDYTSASSKIISWAESKKIGRKKIQFKLRDWLFARQRYWGEPIPLVHYPSGVTKPIPESELPLVLPNLEEFKPSGTGESPLALAKDWLQYKDPSTGEIGTRETNTMPQWAGSCWYYLRYIDPKNGRFLCDPELEKKWMPVNLYVGGSEHAVLHLLYSRFWHKFLFDIGAVSTKEPFDKLIHQGLILGEDKRKMSKSLGNVVNPDDVIKEYGADSLRLFEMFMGPLEMVKPWSTRGVEGVFRFLNRIWRLFHSGSQESFRLDDVEPTPEELKILHKTIQKVNEDIPNFSFNTAIAQLMIFVNEFTPSDRRPKKVLESFILLLAPFAPHIAEELWKRSGKMESLSYEKFPEADPQYLVESEILIVVQVNGKLRDEFKAPKDVSQSDAISMAKNLDKIKGILEGKTIRKEIYVPGKLVNLVIG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA_I43A0
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNIVKPHEKGINPNYLLSWKQLLAELQDIENEGKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVSDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSALGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAVEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: RPH3L_MOUSE
Sequence: MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRSQCLSPGELEIILQVIQRAERLDILEQQRIGRLVERLETMQRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTETQPPSAETSRVYTWARGRVVSSDSDSDSDLSSSSLEDRPLPSGVKGTKGDKPRGDSGASMESPRLGPARPPSHLSGSQSSLGSEAGTGATEPQGGTPAQPEPRVPGKRHTWATPRY
What is the function of this protein?
Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells.  Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A.  Acts as a potential RAB3B effector protein in epithelial cells.
What are the official names of this protein?
Rab effector Noc2, No C2 domains protein, Rabphilin-3A-like protein.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the exocytic secretory vesicles by RAB27A.
Protein: EFTU_PHYMT
Sequence: MSSKVFLRDKVHVNVGTIGHVDHGKTTLTAAITKILSTKGLAENKSYDQIDKTKEEKERGITINTTHVSYETEKRHYAHVDCPGHADYVKNMITGAAQMDAGILVVSAYHGVMPQTREHVLLAGQVGISKLIVFLNKCDLVKEEEWIHLVEMEVRELLNEYKFDGDKTPFVRGSALKALEGTDVEGINKLLEVLDEYIEDPIRDVEKPFLMPVEGVHTITGRGTVATGRVERGKIKISEEVEIIGLKETKKAIITGLEMFKKELDFAQAGDNVGILLRGITRDQIERGQVLAKPGSLNAYHKFLSQVYILTQQEGGRHTAFFSNYRPQFYFRTTDVTGFIKLKKDVKMVLPGDRTELIVELNHPIAIEAGTKFSIREGGRTIGAGTVTEIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CONGA_CONAV
Sequence: GAYFDGFDVPCVPRRDDC
What is the function of this protein?
Does not show any effect on voltage-gated sodium, potassium channels, and on nicotinic acetylcholine receptors (10 uM of toxin tested) (PubMed:27801785).  Does not show antibacterial activity on both Gram-negative and Gram-positive bacteria (PubMed:27801785).
What are the official names of this protein?
Conotoxin AusB.
What is the protein family that this protein belongs to?
Belongs to the ConoGAY family.
What are the subcellular locations of this protein?
Secreted.
Protein: 1433E_BOVIN
Sequence: MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:7931346).  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:7931346).  Binding generally results in the modulation of the activity of the binding partner (PubMed:7931346).  Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (By similarity).
What are the official names of this protein?
14-3-3 protein epsilon, 14-3-3E.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Melanosome.
Protein: TRMN6_FLAJ1
Sequence: MFQFKQFSVKQDKTAMKVGTDGVLLGSWAPVFHNPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLDEFIEEPEDEYDLIVSNPPFYAEDYKTNDEQRDLARFQDAMPFEEIVEAADLLLSENGILAVIIPFKEEAKFTALAKDFELYPIKITRVKGTPKSEIKRSLLAFSRNEVSEIEIDELVIEIDRHIYTPEYIDLTKEFYLKM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIC60_YEAS6
Sequence: MLRTTASRKIVLRRGLASINTGTTVASKKASHKFRNTFWTIALSATAFYAGGIIYSQKNDKFGDFFSNNVPFAEDLLETYEHYHDRPTLFLEDSWDGLKAKSNDLLSGLTGSSQTRRSNRENIEVKKILSLEPLNIETENSDPQLKEIIGSLNDLINSLNDSNLSIPESEFNSIKKSNQNMLTNLSQLNETLKEALSNYMIQRTSEVITELNTQYENSKREFEKNLQKNLLQEVDEFKENLTKQKDKELEEKLKANEELLQAKHANEVGLLSITQVKEFNKIIKDKIEKERNGRLAHLEEINSEVNDLSKSIDRSSKILSKNEALVQLTFQVDEIKSRINNNNLPDVNIDKELSRLKLLSNLLSTFNKKSCCDDGDCCSCKKGNKNEGKEGKISCKCKPKTNPPSLLSVVYDELESTCSGKKILSNEQIYNRWNLLADDFKTASLLPPNSGILGQLTAKVFSLFLFTKTGNPSNATDFDSVYARVGDNLRVSNLNDAVEEVVSLKGWPHKVCESWIEDARRKLEVQRLVEILDCEIRTL
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.  Plays a role in keeping cristae membranes connected to the inner boundary membrane.  Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
What are the official names of this protein?
MICOS complex subunit MIC60, Mitofilin.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic60 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: ENGB_ECO24
Sequence: MTNLNYQQTHFVMSAPDIRHLPSDTGIEVAFAGRSNAGKSSALNTLTNQKSLARTSKTPGRTQLINLFEVADGKRLVDLPGYGYAEVPEEMKRKWQRALGEYLEKRQSLQGLVVLMDIRHPLKDLDQQMIEWAVDSNIAVLVLLTKADKLASGARKAQLNMVREAVLAFNGDVQVETFSSLKKQGVDKLRQKLDTWFSEMQPVEETQDGE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: RR19_ORYNI
Sequence: MTRKKTNPFVAHHLLAKIEKVNMKEEKETIVTWSRASSILPAMVGHTIAIHNGKEHIPIYITNPMVGRKLGEFVPTRHFTSYESARKDTKSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PRELP_RAT
Sequence: MRASFFWFLPLLLILASVAQGQPRPKPGIRRKPKPRPTPSFPQPHEPAEPTDLPPPLPPGPPSVFPDCPRECYCPPDFPSALYCDSRNLRKVPIIPPRIHYLYLQNNFITELPVESFKNATGLRWINLDNNRIRKVDQRVLEKLPGLAFLYMDKNQLEEVPSALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVFKADTFQGLKNLMQLNLAHNILRRMPPKVPPAIHQLYLDSNKIETIPSGYFKDFPNLAFIRMNYNKLSDRGLPKNSFNISNLLVLHLSHNKISNVPAISNKLEHLYLNNNSIEKINGTQICPSNLVAFHDFSSDLENVPHLRYLRLDGNFLKPPIPLDLMMCFRLLQSVVI
What is the function of this protein?
May anchor basement membranes to the underlying connective tissue.
What are the official names of this protein?
Prolargin, Proline-arginine-rich end leucine-rich repeat protein.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: UQCC2_MOUSE
Sequence: MAALRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQIAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSVEEYKLILSTDTLEEFQEMNKSMWKKLQEKFAPTRPEEKHKAWTRVLSRPRT
What is the function of this protein?
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).  Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells.  Involved in cytochrome b translation and/or stability.
What are the official names of this protein?
Ubiquinol-cytochrome-c reductase complex assembly factor 2, Mitochondrial nucleoid factor 1, Mitochondrial protein M19.
What are the subcellular locations of this protein?
Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion. Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion inner membrane. Note=Predominantly expressed in the mitochondrial inner membrane.
Protein: HUR_KITAU
Sequence: MRGTPAVLVDGKPVGAKDGSMFDAAGFARTLKGRAWLRRVGAVVEIPAELVEVQLRYGGAAGREFVEGLPGRVAEFLERWGLRVAGPAMHGMTALVLPVVRADGTEAALKLLVPDEESAGEPVALRAWDGRGCVRLLEWDGPTGTLLLERLDAGRHLSGLVERDARAAVTVVAGLLARLTSVRAPEGLRGLGEVAAGLLAGVPEAAGRLADAGERRLLRDCAAALAEVAAEPGDRLLHWDLHFGNVLAGEREPWLAIDPKPLAGDPGFELLPALVNGFRAGEVGWRFDLLTGVVGLDRERARAWTLGRVVQNCLWEVEDGEVALPEREVAVAEVLLGRAG
What is the function of this protein?
Potential phosphotransferase that inactivates hydroxyurea by phosphorylation of the hydroxy group in the hydroxylamine moiety.
What are the official names of this protein?
Hydroxyurea phosphotransferase, Hydroxyurea resistance protein.
What is the protein family that this protein belongs to?
Belongs to the aminoglycoside phosphotransferase family.
Protein: TR105_MOUSE
Sequence: MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNNKLSMTGFLLIGLATSRIFIVWLLTLDAYAKLFYPSKYFSSSLIEIISYIWMTVNHLTVWFATSLSIFYFLKIANFSDCVFLWLKRRTDKAFVFLLGCLLTSWVISFSFVVKVMKDGKVNHRNRTSEMYWEKRQFTINYVFLNIGVISLFMMTLTACFLLIMSLWRHSRQMQSGVSGFRDLNTEAHVKAIKFLISFIILFVLYFIGVSIEIICIFIPENKLLFIFGFTTASIYPCCHSFILILSNSQLKQAFVKVLQGLKFF
What is the function of this protein?
Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
What are the official names of this protein?
Taste receptor type 2 member 105, T2R105, Taste receptor type 2 member 5, T2R5, Taste receptor type 2 member 9, T2R9.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PNCB_SALPA
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADAIREQVDAMQHLRLQEDEFQWLSGLPFFKPDYLNWLREFRYNPAQVCVTNDNGKLNIRLTGPWREVIMWEVPLLAVISELVHHYRSPNAGVDQALDALESKLVDFTALTANLDMSRFHLMDFGTRRRFSREVQQAIVKRLQQESWFVGTSNYDLARRLALTPMGTQAHEWFQAHQQISPDLATSQRAALAAWLNEYPDQLGIALTDCITMDAFLRDFGIEFASRYQGLRHDSGDPVAWGEKAIAHYEKLGIDPLTKTLVFSDNLDLQKAVELYRHFASRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPQVRKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: CA11_CONBU
Sequence: MGMRMMFTVFLLIVLATTVVSFSTDDESDGSNEEPSADQTARSSMNRAPGCCNNPACVKHRCG
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity).
What are the official names of this protein?
Alpha-conotoxin-like Bu1.1, Bu18.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GP3D_CHLMU
Sequence: MGNSGFYLHNTSNCVFADNIKVGQMTEPLTDQQIILGTSTTPVAAKITASEGISLTITNNAQANSSVNIGLDAEKAYQLILDKLGDQIFDGITGSIVESAVQDIIDKITSDPSLGLLKAFYNFQITGKIQCNGLFTSSNVTTLLGGTEIGRFTVTPRSSGSMFLVSADIIASRMEGGVVLALVKEGDTQPCAISYGYSSGVPNLCSLKTCVTNSGSTPTTYSLRIGGLESGVVWVNALSNGNDILGITNTSNVSFLEVIPQKNT
What are the official names of this protein?
Virulence plasmid protein pGP3-D.
Protein: RS16_CLOBM
Sequence: MAVKIRLKRMGAKKAPFYRVVVADSRSPRDGRFVEEIGYYNPITEPSTIKLDEEKVQKWIKNGAQPTDTVKKLIEKAGISVK
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: QULI_PENCI
Sequence: MKHFRDLDLSSYSLSSVSGFLPERPALERLPNPYYDHWEDLSRNLPQLVASDTLKDKLERLPILSTALLDSEEEWRRAYVVLSFLSQGYIWSGDQPRRNLPIAIAAPLRRVSEYLTIMPCGTFAAYCLWNVIPSPKFGNPQINPEDFISTCTFTGSKEEEWFYVISVAIEARGGRLIPKILDAIDAVKENDTPRVRSFLEAFITCVDGIILVLDRMGENLSQEFFYHRLRPYLRGGKNMAQVGLPDGIFYPLCQCEGGEGEWLAYSGGSNAQSSLIQLMDITLGTCQNVEFIKEMRNYMPGPHREFLELMTSVSNIRPYILSLGNDSDVRSLYDKAVLRLAALRDCHLRVVARYILIPAGKKNPSGHRQLQERGRGTGGTDIMKFLRETRNNTLSACCEQSKGSTVVQTYPKRCETCGSGPIDRTTLIKKATVVINEIEC
What is the function of this protein?
Indoleamine 2,3-dioxygenase; part of the gene cluster that mediates the biosynthesis of quinolactacin A2 (QUL A2), a fungal alkaloid that features a quinolone-gamma-lactam hybrid, which is a potential pharmacophore for the treatment of cancer and Alzheimer's disease (PubMed:32663343).  The quinolone-gamma-lactam hybrid scaffold is synthesized from the combination of L-isoleucine (L-Ile) and the nonproteinogenic amino acid L-kynurenine, followed by quinolone cyclization, oxidative decarboxylation, and lactam formation (PubMed:32663343).  Additionally, the N-methyl group is derived from methionine, which might be catalyzed by an S-adenosylmethionine (SAM)-dependent methyltransferase (PubMed:32663343).  Bioconversion of L-tryptophan to L-kynurenine could be catalyzed by the indoleamine-2,3-dioxygenase (IDO) qulI to produce an unstable product, N-formyl-L-kynurenine, followed by kynurenine formamidase catalyzed hydrolysis (PubMed:32663343).  QulM then acts as a methyltransferase that methylates L-kynurenine at the N-4 position (PubMed:32663343).  The FMN-dependent alpha-hydroxy acid dehydrogenase qulF than functions as an oxidative decarboxylase which converts N-methylkynurenine into 2-aminobenzoylacetamide via 2 tandem reactions, including dehydrogenation and decarboxylation (PubMed:32663343).  An amidase located outside of the qul gene cluster further produces the unstable beta-keto acid precursor N-methyl-2-aminobenzoylacetate, which could be spontaneously dehydrated to form N-methyl-4-hydroxy-2-quinolone (PubMed:32663343).  The NRPS qulB is able to incorporate N-methyl-2-aminobenzoylacetate and efficiently compete with the spontaneous reaction (PubMed:32663343).  By further extending the beta-keto acid with L-Ile, qulA performs a Dieckmann condensation to form the gamma-lactam ring and release a 4-ketopyrrolidinone intermediate from the assembly line (PubMed:32663343).  This intermediate could plausibly further undergo a spontaneous cyclization to yield the final quinolone-gamma-lactam hybrid structure (PubMed:32663343).
What are the official names of this protein?
Indoleamine 2,3-dioxygenase qulI, IDO qulI, Quinolactacin A2 biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the indoleamine 2,3-dioxygenase family.
Protein: KAPR_SCHPO
Sequence: MSFEEVYEELKALVDEQNPSDVLQFCYDFFGEKLKAERSVFRRGDTITESFSDGDESDFLSELNDMVAGPEAIGPDAKYVPELGGLKEMNVSYPQNYNLLRRQSVSTESMNPSAFALETKRTFPPKDPEDLKRLKRSVAGNFLFKNLDEEHYNEVLNAMTEKRIGEAGVAVIVQGAVGDYFYIVEQGEFDVYKRPELNITPEEVLSSGYGNYITTISPGEYFGELALMYNAPRAASVVSKTPNNVIYALDRTSFRRIVFENAYRQRMLYESLLEEVPILSSLDKYQRQKIADALQTVVYQAGSIVIRQGDIGNQFYLIEDGEAEVVKNGKGVVVTLTKGDYFGELALIHETVRNATVQAKTRLKLATFDKPTFNRLLGNAIDLMRNQPRARMGMDNEYGDQSLHRSPPSTKA
What are the official names of this protein?
cAMP-dependent protein kinase regulatory subunit, PKA regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the cAMP-dependent kinase regulatory chain family.
Protein: SECY_CYAPA
Sequence: MLSRLIISIFIIFETIYLQIFKPVNKTFKQGEAKLKRTLQTLQSRELSEIRKRAISTLCLIFLIRIGTFLPIPGTALNFDLESFQQNNSRNELANILNLLSGGAFLEIGFFTLGILPYMNASFFLQVLTKILPSLERFQKEQEEIAQREFKKWTRYLTVIWAFIQSIVISWIWIRPYALNWDFFLGLKVVVALTLGAVIVMIIAEQITEIGLTNGSSLLIFINIIARIPNSIEQLFNSNINWTFPMISSLILSLSLSFITMFVIIGLQESGRPVPVLIARQEAERQKFNEPITEAERRKTQAYIFFQLLPAGIMPVIFASTIFDLALPAFTNFLLQQGNWGYQLIKSFPFNSLFKDFCYLITIMLFSSNYALTIMINPKTLAENLNSMNALIPGVRPGSETKVYSEQLIHRLNFIGSFVLALVCILPSIVERSLGLPKLQILSPVSISIALGVAVDTTRRITSYLGSSSPFKRDSSKREPLKRDFSKRRSAN
What is the function of this protein?
The central subunit of the protein translocation channel SecYE.  Consists of two halves formed by TMs 1-5 and 6-10.  These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back.  The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug (By similarity).
What are the official names of this protein?
Protein translocase subunit SecY.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Multi-pass membrane protein. Plastid, cyanelle inner membrane; Multi-pass membrane protein.
Protein: RS12_PELPB
Sequence: MPTIQQLIRLGRSVKASKTASPALEKCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNKIEVTAYIPGEGHNLQEHSIVLIRGGRVKDLPGVRYHIVRGSLDTSGVADRKQSRSKYGAKQPKAGVPAPVKGKGKR
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.