PharMolix/UniProtQA huggingface dataset:
Protein: RPOC2_ACAM1
Sequence: MAENSTHSPREATPPAFCNKIVNKGQLKSLVHWAFTHYGTARTAEMADHLKDLGFRYATKAGVSISVDDLQVPPSKRRLLETAEEEIRVTEDRYTRGEITEVERFQKVIDTWNGTSEELKDEVVKNFKSNNPLNSVYMMAFSGARGNLSQVRQLVGMRGLMADPQGEIIDLPIKTNFREGLTVTEYIISSYGARKGLVDTALRTADSGYLTRRLVDVSQDVIIRELDCGTQRGIPVQSMTDGDRVLIPLANRLLGRVVLQEVVHPETGEVILPKNEAVSESIAKEIAKAGVEEVVVRSPLTCEAARSVCQHCYGWSLAHAHLVDTGEAVGIIAAQSIGEPGTQLTMRTFHTGGVFTGEVARQIRAPFNGKIKFPKKMRSRPFRTRHGEDALTAEVSTSLTLEGDDQTETFEITQNSTLLVKDGQAVKMGQMLAEVAAAGRNVRKTTEKATKDVASDLAGEVQFSNLVPEEKHDRQGNTTRIAPRGGLIWVLSGEVYNLPPGAEPTVKNDDYIEGEDVLAETKLVTEHGGVVRLPVQEEGKGGREVEIITASVLLDQAKVWLESLQGRDQYVIEAQKKQRFLLKAAPGTKVINGQVVAELIDDHYRTKTGGILKYAGVEVTKKGKAKQGYEVTQGGTLLWIAEESHEVNKDISLLLVEDGQYVEAGTEVVKDIFCQSNGVVEVTQKNDILREVLVKPGDLHLVDDPEAVKGKDQSLLNPGEELLPGLSTDELRYIECVTTPEGEAVLLRPVTEFPVPDQPSVPSQESINEAGRAICLKAVQRLPYKDGERVKSVEGVDLLRTQLVLEIDTDAPQIAADIEILPDEKDEEVSRLQLVILETLVIRRDVSADQTQGSTKTRLLVEEGQQIDPGAVVARTEIKAKQGGKVRGIRSGNEATRRILLMTDDDLITIETQGKATSASEGELLRAGDEVAAGVTVAESCQVIKVQDGQVTLRIARPYLVSPGAVLQIDDQDLVQRGDNLALLVFERTKTGDIIQGLPRIEELLEARKPKEMCTLAQRSGTCQVIYNDDDSIEVKIVEQDGTITDYPIGPGQNPIVLDGQTVEAGEAVTDGPLNPHDILEIYFRFHRETKGVYESALLSLQKVQNFLVNGVQSVYQSQGIDIADKHIEVVVRQMTSKVRIDDGGDTTMLPGELIDLYQVEQVNAAMSITGGAPAEYTPVLLGITKASLNTDSFISAASFQETTRVLTEAAIQGKSDWLRGLKENVIIGRLIPAGTGFNSYDDGGLGEPDPSFEGMPFTDDDDVIDDRTARNYNINDVKPFSGERPAYDPSKPGEQQRSMLGIDPAAVGDDTLIDDQVAEKLNANLEGDQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
Protein: GSA_SYNAS
Sequence: MTKSLSEQLFETAEGLLPGGVNSPVRAFRAVGGVPRFIDRAEGSRIYDIDGREYIDYVGSWGPMILGHSHPQVVEAIRKAVERGTSYGAPTPGEIALARTIIEAFPSMEMIRMVSSGTEAVMSAIRLARGFTGRDKILKFEGCYHGHGDSLLVKAGSGVATLGIPGSPGVPACLAELTITVPFNSNEAFRKAVDRHGKELACVIVEPVAANMGVVNPRPGFLETLRELTRKAGIVLIFDEVITGFRLAYGGFQKLCRLEPDLTCLGKIIGGGLPVGAFGGKRTIMDFLAPNGPVYQAGTLSGNPLAMSAGLATLETLRSRRDDYAALDRRTADLCAAMGKLFRTAELPVRINRAGSLFTVFFTDSDVFDYETASHCNLERYARFFKGMLDRGVYLAPSAFEAAFVSFAHSDEDLEKTLQACAETIKTLGGNP
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_CHLPM
Sequence: MSKVCVLTGKRPKYGNTVSHANNHRRTRFEPNLHTKRIWIEEEKRWAKVKLSAKAMRIIAKTGTGELAKLLK
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: PDXT_ROSS1
Sequence: MTVGILALQGDFREHEEMLRRIGAPTLQVRLPKHLQHVERLIIPGGESTTIGKLLAMYGLIDPLRARIRDGMPVWGTCAGAILLAQRIADGRADQPSLRLMDVTARRNAFGSQLESFEVDLPVLGLGDEPLRMVFIRAPVLEDLGRDVTPLAHLDDGRVVAARQGTMLATCFHPELTPDERMHRYFLAM
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: RL18_SINFN
Sequence: MASRKDTLVRRASRVRRQIKAVANGRPRLSVHRSSKNIYAQIIDDVAGKTIAAASTLEADLKSALKTGADTAAATAVGKLLAERASKAGVKDVVFDRGAFIYHGRVKALAEAAREGGLNF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: COI1_ARATH
Sequence: MEDPDIKRCKLSCVATVDDVIEQVMTYITDPKDRDSASLVCRRWFKIDSETREHVTMALCYTATPDRLSRRFPNLRSLKLKGKPRAAMFNLIPENWGGYVTPWVTEISNNLRQLKSVHFRRMIVSDLDLDRLAKARADDLETLKLDKCSGFTTDGLLSIVTHCRKIKTLLMEESSFSEKDGKWLHELAQHNTSLEVLNFYMTEFAKISPKDLETIARNCRSLVSVKVGDFEILELVGFFKAAANLEEFCGGSLNEDIGMPEKYMNLVFPRKLCRLGLSYMGPNEMPILFPFAAQIRKLDLLYALLETEDHCTLIQKCPNLEVLETRNVIGDRGLEVLAQYCKQLKRLRIERGADEQGMEDEEGLVSQRGLIALAQGCQELEYMAVYVSDITNESLESIGTYLKNLCDFRLVLLDREERITDLPLDNGVRSLLIGCKKLRRFAFYLRQGGLTDLGLSYIGQYSPNVRWMLLGYVGESDEGLMEFSRGCPNLQKLEMRGCCFSERAIAAAVTKLPSLRYLWVQGYRASMTGQDLMQMARPYWNIELIPSRRVPEVNQQGEIREMEHPAHILAYYSLAGQRTDCPTTVRVLKEPI
What is the function of this protein?
Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses.  Seems to not be required for meiosis.  Required for the regulation of some genes induced by wounding, but not for all.  Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6).  These SCF complexes play crucial roles in regulating response to jasmonate, and their interactions with the COP9 signalosome (CSN) appear to be important for their activity.  Interacts with TIFY10A and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor.  Involved in the regulation of plant gene expression during plant-pathogen interactions with Pseudomonas syringae and Alternaria brassicicola.
What are the official names of this protein?
Coronatine-insensitive protein 1, COI-1, F-box/LRR-repeat protein 2, AtCOI1, AtFBL2.
Protein: RS3_BACFR
Sequence: MGQKVNPISNRLGIIRGWDSNWYGGNDYGDSLLEDSKIRKYLNARLAKASVSRIVIERTLKLVTITVCTARPGIIIGKGGQEVDKLKEELKKVTDKDIQINIFEVKRPELDAVIVANNIARQVEGKIAYRRAIKMAIANTMRMGAEGIKIQISGRLNGAEMARSEMYKEGRTPLHTFRADIDYCHAEALTKVGLLGIKVWICRGEVFGKRELAPNFTQSKESGRGNNGGNNGGGKNFKRKKNNR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: SYL_HELPH
Sequence: MDFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIEAMQKEFEALGFSFSKNREFATSDPDYTKFEQQFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQVIDGRCWRCDTEVVQKELYQYYLKITNYAEELLKDLETLEDHWPSQVLIMQKNWIGKSSGLQFGFKIADECLKACNGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKRVSQEDSKIIKAILNTTQRERALEKKGAFLGIYAIHPLTKQKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQSLQNLPHTKEEVLKNSGEWSDLSSSVAREQIIAYFEKENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCKHCGIVPETQLPVTLPEDIVIDGEGNPLEKHASWKFAQCPKCHKDALRETDTMDTFIQSSWYFLRYTTPKNQRENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRDLGYLHLDEPFKQLITQGMVLKDGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEGAHRFIKRLYDKANAITPTTSKPEFKGVILNEAQKLARKKVYEALKKSHEIFNKTESTYAFNTLIASCMEALNALSAQNNERILCEGYFVLLQILEPIIPHTAWELSERLFKRENFKPIAIDESALMEDFMTLGLTINGKRRAELKVNINASKEEIIVLAKKELEKYLEKASVKKEIYVPNKLVNFVIA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P53_MACFA
Sequence: MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSPLPSQAVDDLMLSPDDLAQWLTEDPGPDEAPRMSEAAPPMAPTPAAPTPAAPAPAPSWPLSSSVPSQKTYHGSYGFRLGFLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPCHQLPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPAGSRAHSSHLKSKKGQSTSRHKKFMFKTEGPDSD
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: MENG_NOSS1
Sequence: MTNKIRAIFDRIAPVYDQLNDWLSLGQHRIWKEMAIKWTGAKPGDTCLDLCCGSGDLALRLARRVGSTGQVSGVDFSANLLETAKQRAQSQYPQPNISWVEANVLDLPFKDNQFDAATMGYGLRNVTDIPRSLQELHRVLKPNAKAAILDFHRPNNQQFRTFQQWYLDSIVVPLADRLGVKEEYAYISPSLDRFPIGKEQVEIALKVGFTSATHYPIANGMMGVLIISK
What is the function of this protein?
Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.
What are the official names of this protein?
2-phytyl-1,4-naphtoquinone methyltransferase, Demethylphylloquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: FPG_SALTY
Sequence: MPELPEVETSRRGIEPHLVGATILHAHIRNGRLRWPVSDEIYRLSDTPVLSVQRRAKYLLLELPDGWIIIHLGMSGSLRILPEALPAEKHDHVDLVMSNGKILRYTDPRRFGAWLWTKELEGHNVLAHLGPEPLSDEFNGEYLQQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSTEECDLLARVIKAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATFYCRHCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: SELA_DESAP
Sequence: MELNTGDVMRRLPAVDELLREPELEMLLAEHPRALVVAAVREVLQQWRETVRAEPERVPGSREELAAAIVQEVTITVRAKARPALRRVINATGVVLHTNLGRAVLSDKALRAVHEAAAHYSNLEFNLETGRRGSRYALVEDLLKLLTGTESCLVVNNNAAAVLLALSTLAAGREVIVSRGQLVEIGGSFRIPEVMKQSGARLVEVGATNKTHLRDYRDAITSETALLLHVHASNYRIVGFTHEVGLEELVALGREHGLPVMSDLGSGFLVDLSRFGYPYEPTVQETAGAGVDVVTFSGDKLLGGPQAGIIVGRREVVDRMKKNPLTRAVRVDKMTLAALEATLREYLDPEGALERIPTLRMLSVGAVVLAEKARRLAGLLGAALGDRAEVGVEEDFSQVGGGALPTAQPKTVLVTVRPKALSLTELTARLRAADPAVVGRVQEERLCLDPRTIAEDEFVLLTGTLDRVLGVPQ
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_MESH2
Sequence: MKKHAKVYYSENLVEQVNEFETSFEIKPLERGLGNTLGNALRRTVLSSIPSCAVFGVKIEGIKHEFTVLDDVIEDVVTILNNLKRVRFFYNPSVFSQNSIHVASFLGQKAGQIYARDIESHSGLKIVNPDLYIADVSKVGALKFELFITNGKGFVDFETNKKYVNEVISLLESQIEGSVLAVDSDFSPVLNANYQAVEINSASPIIEEKLNFSIKTDGSIFAKDALSQGAKILIAHLNLLADVENLNKFSADFFGDQEIKEEPIRRFSNSIDALDLSVRSLNALRRAQYYKISDIEKLSQDDFENIKNLGRKSVQEIMEKLQNYKNENKGEN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: Y230_XANC8
Sequence: MLHYAIIFFVIAIIAAVLGFSGIAGAATNIAWILFVVFLILAVISMFRRGKV
What are the official names of this protein?
UPF0391 membrane protein XC_0230.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HXD1_MOUSE
Sequence: MSSYLEYVSCAAGGGSGGVGGDVLGFAPKFCRADARPVALQPAFPLGSGDGAFVSCLPLATARPTPSPPAGPAQSPVPQPAAPRYAPCTLEGAYERGAAPASAAEYGFLGSGPAFDFPGALGRAADEGGAHVHYATSAVFSGGGSFLLSGQVDFAAFGEPGPFPACLKEPADGHPGPFQTVSPAPGACPKPASPTSSLPAAHSTFEWMKVKRNAPKKSKLSEYGATSPPSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLQLNDTQVKIWFQNRRMKQKKREREGLLATAASVASIKLPRSETSPIKSGRNLGSPSQAQEPS
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Acts on the anterior body structures.
What are the official names of this protein?
Homeobox protein Hox-D1, Homeobox protein Hox-4.9.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Labial subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1082_LISMF
Sequence: MTFKGFSKKDFKTMQIPGLEARMNGIQTDIQPKFRAVGEELTTYLSAKLGDEMFLHIARHQRRSVNPPESTWLAICHDKRGYKKHPHFQVGLFDNYLFIWLAFIYENEESAKIANRFLKEKKLLADLPDNFAISPDHTEEKTYPVHDGQLKATLERFRDVKKGEFLVGKIYLPDDSHLSPGKDFIKEAEMVLDELIPLYKASLQ
What are the official names of this protein?
UPF0637 protein LMOf2365_1082.
What is the protein family that this protein belongs to?
Belongs to the UPF0637 family.
Protein: RL24_STAAB
Sequence: MHIKKGDNVKVIAGKDKGKEGKVIATLPKKDRVVVEGVNIMKKHQKPTQLNPEGGILETEAAIHVSNVQLLDPKTNEPTRVGYKFVDGKKVRIAKKSGEEIKSNN
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: BR2A_RANTE
Sequence: MFTMKKSLLLFFFLGTISLSLCQEERNADEDDGEMTEEEKRGILDTLKNLAKTAGKGILKSLVNTASCKLSGQC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Brevinin-2Ta.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: ATG4_PENRW
Sequence: MTMDMEKCKRIVQYFWDPEPRNDVPAASIWCLGREYAPSQPPSDPASNNPRSPSRQPNASTLNDTTWPKAFLSDFGSRIWITYRSNFTPIPRTKTPEATSSMTLGVRLRSQLMDPQGFTSDTGWGCMIRSGQSLLANTFSVLLLGRDWRRGEKVEEESKLISMFADHPEAPFSIHRFVNRGAESCGKYPGEWFGPSATAKCIQLLSTQSEVPQLRVYLTNDTSDVYEDKFAHVAHDESGRIQPTLILIGTRLGIDNVTPAYWDGLRAALTYPQSVGIAGGRPSASHYFVGAQDCHLFFLDPHTTRPATLYRPDGLYTQEELDSYYTSRLRRIHIKDMDPSMLIGFLVKDEDDWADWKKRIRSTPGQPIVHIFPSQHQPDHGHGRAEALDEVEALDDSDEME
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8 (PubMed:17204848).  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS (By similarity).
What are the official names of this protein?
Probable cysteine protease atg4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: RL14_BACLD
Sequence: MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVKQATPGGVVKKGDVVRAVVVRSKSGARRNDGSYIKFDENACVIIRDDKSPRGTRIFGPVARELRDNNFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: MCP1_THEMA
Sequence: MSLRKKVFLLMIVVVAGLLLSFFLIYRSVSNSIINSVRSNTENQAKALSKFVVEKLNNVTNVARSAATYLGSQFFEAYMITNQLKTTVEKEKSTFAFAFSALSFNKSAALTDGNRVDRVDFADYEKYIKAVEGKDIFFMPETFQGTPVLTVVVPIETMNTRTGIVGFGINLSENSDLWKAVVEEGKASKSGYGLLVTSDGKVLIHKDMGNFMKDVKELGGFEKAFEEAKSGGEKYVEYEYNGEKKYTVWEKVPGYDFYIFSTGYLEELLAEGRKATLGTIVTYVVFGGVIFAVLFVSMMPVVKRMRQQVEKVKRFGEGDLTVEFEAKGRDELTQIEESLKEAALSLKEMIVSIIEAAKELSGASEEIKVLSEESHKMSENLHEEAKKILDEANNMSSALTEVTSGVEEVAASAQNISKITQDLTERSEAVTKAAREGTERVEAVGGVINKLKGSAERQRDYLRELVDSAKTIGEIVDTISSIAEQTNLLALNAAIEAARAGEAGRGFAVVADEIRKLAEESQRATEDIAKMLSSLRTTIEHVENGSKEMFEGVDEIAVMGEEVTKRFREILGRIEEINSMIENTAATAQEQGAAAEEMASAMDNVTKIVEGVVESLNRMESLIEDQTTSAAKVSQAAERLSELSEQLSTLVQKFKV
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.
What are the official names of this protein?
Methyl-accepting chemotaxis protein 1.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL24_HELHP
Sequence: MAKFKIKKGDMVQVIAGDDKGKKAKVLQVLPKQAQVIVEGCKVVKKAIKVSEKNPKGGFVSKEMPMSISNVKKAEGDN
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ZN512_MOUSE
Sequence: MSSRLGAVTATPGPTSLKQQRSTRIVGAKNNRAQCSIKDNSFQYTIPHEDSLSGSSSASSCEPVSDFTATLRKSTYWMKMRRIKPAATSQVEGAGEKEKERAKGKRNVKQEEDEDYRELPQKKHKLYGRKQRPKAQPHPKPQARRVRKEPPVYAAGSMEEKWYLEIMDKGSVSCPTCQAVGRKTIEGLKKHMENCKQEMFTCHHCGKQLHSLAGMKYHVMANHNSLPILKAGDEVDEPSERERLRTVLKRMGKLRCMRESCSSTFTSIMGYLYHVRKCGKEASELEKLALKCHHCGKPYRSKAGLAYHMRSEHGPVFFPESEQPDCLKEMSLEAKGGGRVQRRSAKIAVYHLQELASAELTKEWPKRKVLQDLVPDDRKLKYTRPGLPTFSQEVLHKWKTDIKKYHRIQCPNQGCEAVYSSVSGLKAHLGSCTLGTFVAGKYKCLLCEKEFVSESGVKYHINSVHAEDWFVVNPTTTKSFEKLMKIKQRQQEEEKQRQQHGRRRSLRRQQQPCMEPPESQLEPKAGKEQGGNEELVGPDPEPVPAQPQKAEPAKTTHKRGRK
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 512.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FBLN5_HUMAN
Sequence: MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF
What is the function of this protein?
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537).  Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity).  Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif.  Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823).  May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
What are the official names of this protein?
Fibulin-5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50.
What is the protein family that this protein belongs to?
Belongs to the fibulin family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.