PharMolix/UniProtQA huggingface dataset:
Protein: INV5_ARATH
Sequence: MANIVWCNIAMFLLVSLFLTDDAVVVLDALDNVPNNIKNQPYRTGYHFQPPKNWMNDPNGPMIYKGIYHLFYQWNQNGAVMDVNKTVWGHATSTDLINWITLSPAIRPSRPSDINGCWSGSVTILPNGKPVILYTGNDRYNRQVQNLVKPKNLTDPYLRHWTKSPENPLVTPSPVNHINSSAFRDPTTAWFGRDGRWRITTGSQEGRRGLAILHTSKDFVIWKQSPKPLHYHDGTGMWECPDFFPVARTDSRGLDTSFSSGPMVKHVLKVSLTDTFNDYYTIGTYDEVRDVYVPDKGFVQDETAPRYDYGKFYASKTFYDSVNQRRILWGWVNESSPEKDNIKKGWAGLQAIPRKVWLDESGKRLVQWPVKEIERLRTTQVKWGNKLLKGGSVMEVHGVTAPQADVEVFFKVSGFDLEKADVIEPGWTDPQLICSQRNASSGLGPFGLMVLASKNMEEYTSVNIRIFRAGENSKEHVVVMCSDQSTSSLEKGNDKTTYGAFLDISPYQPISLRTLIDKSIVESFGGKGKTCITSRVYPKLAIGERTHLFAFNKGSQNVNVLSLSAWSMKSSL
What are the official names of this protein?
Beta-fructofuranosidase, insoluble isoenzyme CWINV5, Cell wall beta-fructosidase 5, Cell wall invertase 5, AtcwINV5, Sucrose hydrolase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 32 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast. Secreted, cell wall. Note=Associated to the cell wall.
Protein: CX7A1_SHEEP
Sequence: LENRVAEKQKLFQEDNGLPVHLKGGATDN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7A1, mitochondrial, Cytochrome c oxidase subunit VIIa-heart, Cytochrome c oxidase subunit VIIa-H.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIa family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PPK6_PSEFV
Sequence: SDPEVPGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-6, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y444_MYCPN
Sequence: MHTFTRKVKWPFMFTAIGLTFGIVAVACAQPTASTVEGLFKPSSAFADRTDFSLSSILQKSLINRESFNQYLAMRLAPVLRTFYEDNYDTDIKERLNGFTADTDNAFVSQEQNLRNQFRENYLVHLQTDIFDNTGGNQAAWKLRDVNNKIIDDFISRIFAKNFVEYVQDGVGPLTKPTKSLIENTSNFKNIKLQPKFVNKNAKLKINNDAVYAAIQDKLLDQFITNENPNLVSRVVFTNETPVDGFDNYFNTKVIQSPTPSYQFQVFNKYNQQSGGTKGANGFNLLASNLKSYKNDQSKGIDIPNKFSSDSGGKLLLKASDMFDTFDPSFSAAFIQGYLALQKKSKGADSKEVDSLIKDKSIIENFFVDNNTQAAAAARAASSSSEGTIQLKTASDGGGTTQSTVHKTDLVKIFGDKDVFAGEYKQQIGNTNANQTGGGGSGGGGGTSTGSSTGSSTETTTGNSSKAVVDLIEVKKDSSSQPDYILSRGKDGIHLMAVDGGSHYLTESGRDVAKQKKFLLFRALQTKYGLVDTDTTYDFKLFDEVKKYFDTNRILFLFEALLDLSSDTNNKDNFLSYPQFKKFADSIKSIEKDLKELVQAHYKQAVFNETAVAENKVTLKLAERNQPFIDNERNNQIEQNGLAAKLPYEQDAKTGHYNDLGNYYKDIIDNVDKKGTSTVKTTSSNTGQTKNFSEEVVSKLKDNKKKVEEAAKKHVEALKVFTIPSPLYSQVILVQTKLSFTPESTSLGLNLALNNYLTSTELQNSIKLSYFQEDEAFKKIIDITNLTFSQQSGGTGGTNGNNNLTADNWKIFKETYLLDLFESQAQKSIFGHVGSSDKNSSTKTGIEGVLDTLYSSLNLEERLDSDDVIDYLSYLYTAHWLLKDNLKNYKQSLQSKLSRTSNAFLVWSVDSEKNKNDSQSTLSSTASSTSNTGLIQLRSVVSLAQNQAAGQGGDNNSDITQTEVKNPNFVFGSSVYDWTNSKTPEVNRAADDTSSFFYTKSSSSSTGAAQSSATVLRSLNQASGMTTKTAKNRYGFRGIVTSSTSGSLPEAVSRRLFKQFVNQTEKGVKVGGQMLITTAKSGKATLVLKQQADDAESTTNNAYKGALFSFGSMDNLKNIINGIQTQTEFDALYNHLTSDLNIDVTGVDKNKTLTEQKTSLTSFVDSNFKQSTQSAQRGDTSARSARSATVQIKKTQEDNQNTNYKDVFSRFDGYIGDNKVEEKNYTSYQFLSDGGKYHATFVKQVNLDDVEKIGTDSLKQEDSSKDKRLNLSLEEFLAAIALEALDPNNQTQAINALISGNKKGLVKVGDFRIFSSISAQWVRRF
What are the official names of this protein?
Uncharacterized lipoprotein MG309 homolog.
What is the protein family that this protein belongs to?
Belongs to the MG307/MG309/MG338 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: IBP4_SHEEP
Sequence: DEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGKGMPCGVYTPDCGSGLRCHPPRGVEKPLHTLVHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRKCLQKHLAKIRDRSTSGGKMKVIGAPREEVRPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE
What is the function of this protein?
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.
What are the official names of this protein?
Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4.
What are the subcellular locations of this protein?
Secreted.
Protein: RASL_COPC7
Sequence: MAARAQFLREYKLVVVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCIIDDEVALLDVLDTAGQEEYGAMREQYMRTGEGFLLVYSITSRNSFEEISIFHQQILRVKDQDSFPVIVVANKCDLEYERQVGMNEGRDLAKHFGCKFIETSAKQRINVDEAFSNLVREIRKYNREQQTGRPAIAAGGGGPAGSYTQDRHHDEAPGCCAGCVIA
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
What are the official names of this protein?
24 kDa Ras-like protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: ACHA4_MOUSE
Sequence: MEIGGSGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPESEPGILGDICNQGLSPAPTFCNRMDTAVETQPTCRSPSHKVPDLKTSEVEKASPCPSPGSCHPPNSSGAPVLIKARSLSVQHVPSSQEAAEGSIRCRSRSIQYCVSQDGAASLTESKPTGSPASLKTRPSQLPVSDQTSPCKCTCKEPSPVSPITVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-4.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.
Protein: POL2_BAMMU
Sequence: MMMNSTIRQGWQQVLRRFSIPASGDRLIVSNSTDQPIGLFGAFDTSLQTLSQVTNDPEILKQKSNIPTHLDIASVLETSPRSFPWVFLTNSFCTFGGSIHAQNLQAFATAEFKSGFCYMNLLIPLSFDIIDAHADSFRGFVEQLPDTLGAYPSLSMVLNVMLHAATRFPEIVASPVPTIAFDAESLQFHVTDKRGVPGMWNILKACRVYELLSLAADGIGCEYMLYPVGAAPQYSFWKKSMDHFISDRFVEFLAMQGLLASALEQDYKTHDARDALLTALQNAGYTNVVARERRFPNGHDPSTVWLNLNEAPISEKLTELKRYLLVGHRSDEIADITHNVHQHVFEVLKTMSVQFSKTTNAYNRARFEVNHEVIWNAEYGRSSQQNAELEALVLFLNRQSLEIENILRRTTSPVVVTNWQPDVPPAAPEISEGEPTHAVATPITEAPTHATPVEVVNLPPTRSYWAETLVGVLTAILGTIFALLTRALIRPKRLRRKSTFPWVSLDSGDEDDDHSGGGGGSPQTPGGQPPASPAPGTHQSRFSVQDIASDTSLLSVDLDEDTLSQYDETFQTIRRALFENSFGDILQNSARWISTLEAMALADGNAPYTLLAQYLNGIEEAYTNFRNTGHISRATLSGFFVLEDSLRAAGIAFGGTTPTQTIQNQSADSPARRWKTRFEQIACELGDASIKSLADLADIIDTERERGDLTQFDVLAASSISSLCRAVRIISDTTDPNTQLALVENATAMQNNINAILGTNVSIPFLSATRRLLITRRIQEAGAESRSGATPDTIQQLADAELAEIVSEANMFNEMAASQRDIANATREATIREHVLSPVNALANVGMAAAFFRSGGLRSRAFHPTMPTMPGSPAAIGRPMFQAFRGRGHRLNRR
What are the official names of this protein?
Genome polyprotein 2.
What is the protein family that this protein belongs to?
Belongs to the bymoviruses polyprotein 2 family.
Protein: OST4_DROWI
Sequence: MITDVQLAIFSNVLGVFLFLLVVAYHYINANTGKIGPKAK
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the OST4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: PPSE_MYCTO
Sequence: MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQELRDAGVSDKTLADPAYVRRAPLLDGIDEFDAGFFGFPPLAAQVLDPQHRLFLQCAWHALEDAGADPARFDGSIGVYGTSSPSGYLLHNLLSHRDPNAVLAEGLNFDQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLLSGECDMALAGGSSLCIPHRVGYFTSPGSMVSAVGHCRPFDVRADGTVFGSGVGLVVLKPLAAAIDAGDRIHAVIRGSAINNDGSAKMGYAAPNPAAQADVIAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQGLRAAFEVSQTSRSAPCVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALPATLHYTSPNPELRLDQSPFVVQSKYGPWECDGVRRAGVSSFGVGGTNAHVVLEEAPAEASEVSAHAEPAGPQVILLSAQTAAALGESRTALAAALETQDGPRLSDVAYTLARRRKHNVTMAAVVHDREHAATVLRAAEHDNVFVGEAAHDGEHGDRADAAPTSDRVVFLFPGQGAQHVGMAKGLYDTEPVFAQHFDTCAAGFRDETGIDLHAEVFDGTATDLERIDRSQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYIAATLAGVFDLQTAIKTVSLRARLMHESPPGAMVAVALGPDDVTQYLPPEVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSAMDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISSPIRFADELDVVLAAPSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRLMRHPLQDVDDRDTFLRALGELWSAGVEVDWTPRRPAVPHLVSLPGYPFARQRHWVEPNHTVWAQAPGANNGSPAGTADGSTAATVDAARNGESQTEVTLQRIWSQCLGVSSVDRNANFFDLGGDSLMAISIAMAAANEGLTITPQDLYEYPTLASLTAAVDASFASSGLAKPPEAQANPAVPPNVTYFLDRGLRDTGRCRVPLILRLDPKIGLPDIRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEFTGLSNRSVPNGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAAHGGPHYLCLAIHAMVTDDSSRQILATDIVTAFGQRLAGEEITLEPVSTGWREWSLRCAALATHPAALDTRSYWIENSTKATLWLADALPNAHTAHPPRADELTKLSSTLSVEQTSELDDGRRRFRRSIQTILLAALGRTIAQTVGEGVVAVELEGEGRSVLRPDVDLRRTVGWFTTYYPVPLACATGLGALAQLDAVHNTLKSVPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSGDAPVQFDSDMTLPVREPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPAATAEALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMDAG
What is the function of this protein?
Part of the PpsABCDE complex involved in the biosynthesis of the lipid core common to phthiocerols and phenolphthiocerols by successive additions of malonyl-CoA or methylmalonyl-CoA extender units.  PpsA can accept as substrate the activated forms of either icosanoyl (C20), docosanoyl (C22) or lignoceroyl (C24) groups from FadD26, or a (4-hydroxyphenyl)-C17 or (4-hydroxyphenyl)-C19 fatty acyl from FadD29.  PpsA initiates the biosynthesis and extends its substrate using a malonyl-CoA extender unit.  The PpsB and PpsC proteins add the second and third malonyl-CoA extender units.  PpsD adds an (R)-methylmalonyl unit and PpsE adds a second (R)-methylmalonyl unit.  The incorporation of the methylmalonyl units results in formation of two branched methyl groups in the elongated product.
What are the official names of this protein?
Phenolphthiocerol/phthiocerol polyketide synthase subunit E, (Phenol)carboxyphthiodiolenone synthase subunit E, Beta-ketoacyl-acyl-carrier-protein synthase I, Phthiocerol synthesis polyketide synthase type I PpsE.
Protein: KCNQ5_MOUSE
Sequence: MPRHHAGGEEGGAAGLWVRSGAAAAAGAGGGRPGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAAALGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGIDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQMTSDKKSREKITAEHETTDDPSMLARVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLTRSASANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPMSQNDGSSVVATNNIANQISAAPKPAAPTTLQIPPPLSAIKHLSRPEPLLSNPTGLQESISDVTTCLVASKESVQFAQSNLTKDRSLRKSFDMGGETLLSVRPMVPKDLGKSLSVQNLIRSTEELNLQFSGSESSGSRGSQDFYPKWRESKLFITDEEVGAEETETDTFDGTPPPAGEAAFSSDSLRTGRSRSSQNICKTGDSTDALSLPHVKLN
What is the function of this protein?
Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons.  Therefore, it is important in the regulation of neuronal excitability.  May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current.
What are the official names of this protein?
Potassium voltage-gated channel subfamily KQT member 5, KQT-like 5, Potassium channel subunit alpha KvLQT5, Voltage-gated potassium channel subunit Kv7.5.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRH_ACIC1
Sequence: MADGEGGAASAPTAGTRPVYRRVLLKLGGEMFGGGHVGVDPDIVASIARQIAAVVAEGVQMAVVIGGGNFFRGAELSVRGMDRARSDYMGMLGTVMNCLALQDFLEKLGVDTRVQTAITMGQVAEPYIPRRAIRHMEKGRVVIFGAGLGAPYFSTDTTAAQRALEIGAEVVLMAKAVDGVYDSDPKTNADAVRFDHLDYDEVLARDLKFADATAISLCRDNGMPIIVFNLLEEGNIARAVHGEKIGTIVSSGDGVPPRRQAVSPAR
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 361L_IIV6
Sequence: MTSIINQRWPLGNLMDGFPNGEKQNKLSFGGVPEKGYFEEFNKDPKYISFSGTPEKAYFEEFNRYRNIDEDDNRDTFPLFNEISSNPESESYLQTFVDNVRINTDINFVSKTNSFSQNDLSYLNATYVDKSLSLELPIKFNWAKTTSADSPDVVAKKKLISKPDNQYLCGSCWAVSVAGVVGDVFAVAGLVNWVPNISATYALIHYPQGRCKGGDPATLLYNIANNGIPSKHCVDYSWCSQNRTCTTADSAAHFGSDLSPLIPKDRGCYFDSEHYIFKIDSNIRTIVAGSGAIDVSNVQRTIKEYIYTTGPAVGGYIIFRNFTSKVPFGPHKGNSTFNVINGGVYLEKANYAQYRGEYGEHITEGLTFSSSNTDSDNYAGGHAISIMGWGIQPRIRVGNGPNDIADVPYWYCRNSWGTKWGMNGGYFKIAMYPYNRKSQFSKIVELMTPQGQHIRLGGVLAFTVSNPPVLKKLPANKQPPNPNSLSKLLDYYKNDEDDIVTKLPNIVPPSDGKKSTTSKTNNWYIYALIIIFILIIFFVLRK
What is the function of this protein?
Probable cysteine protease.
What are the official names of this protein?
Probable cysteine proteinase 361L.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PDXS_NATPD
Sequence: MSNTDLEELRRGTDLVKRGFAKMQKGGVIMDVVTREQARIAEDAGAVAVMHLESVPADIRKRGGVARMADPGGLEDVIDEVSIPVMGKARIGHTAEAQILEATGADMIDESEVLTQADDRYHIDKREFTAPFVCGARNLGEALRRIDEGAAMIRTKGEAGTGDVNQAVTHQRNIQRSIRKLSGMDYEERDEWAREHGAPRELVHETAEMGRLPVVNFAAGGIATPADAALMMQLGCDGIFVGSGIFGAENPQAMGEAVVAAVNNYDDPETLKEIAKSPGKGMKGQANETLPEEEKLQDRGI
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: PYRR_MYCUA
Sequence: MGAANDAVDGRELMSAAVVGRTISRIAHQIIEKTALDSPDSPRVVLLGIPTRGVILASRLAANIGEYSGIEVDHGALDITLYRDDLMSKPPRPLEETEIPAGGVDDALVILVDDVLYSGRSVRSALDALRDVGRPRSVQLAVLVDRGHRELPVRADYVGKNVPTARSESVHVQFSEHDGHDGVVISR
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: RECX_PELPB
Sequence: MTDNNAPGAMTFALKLLGLRSHSKDELKRKLLKKGYSAEGIEPVIEKLSRMGALDDHAFGMEVIRSRSRRKPSGRLKIVAELRKKGVAETIISELLKEYDSVALCHRAAEKKLASLREMSEADRKRKLEVFLSNRGFEWQEIQSALRLLVLPGADDDEPC
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOBP_HUMAN
Sequence: MAEMEKEGRPPENKRSRKPAHPVKREINEEMKNFAENTMNELLGWYGYDKVELKDGEDIEFRSYPTDGESRQHISVLKENSLPKPKLPEDSVISPYNISTGYSGLATGNGLSDSPAGSKDHGSVPIIVPLIPPPFIKPPAEDDVSNVQIMCAWCQKVGIKRYSLSMGSEVKSFCSEKCFAACRRAYFKRNKARDEDGHAENFPQQHYAKETPRLAFKNNCELLVCDWCKHIRHTKEYLDFGDGERRLQFCSAKCLNQYKMDIFYKETQANLPAGLCSTLHPPMENKAEGTGVQLLTPDSWNIPLTDARRKAPSPVATAGQSQGPGPSASTTVSPSDTANCSVTKIPTPVPKSIPISETPNIPPVSVQPPASIGPPLGVPPRSPPMVMTNRGPVPLPIFMEQQIMQQIRPPFIRGPPHHASNPNSPLSNPMLPGIGPPPGGPRNLGPTSSPMHRPMLSPHIHPPSTPTMPGNPPGLLPPPPPGAPLPSLPFPPVSMMPNGPMPVPQMMNFGLPSLAPLVPPPTLLVPYPVIVPLPVPIPIPIPIPHVSDSKPPNGFSSNGENFIPNAPGDSAAAGGKPSGHSLSPRDSKQGSSKSADSPPGCSGQALSLAPTPAEHGRSEVVDLTRRAGSPPGPPGAGGQLGFPGVLQGPQDGVIDLTVGHRARLHNVIHRALHAHVKAEREPSAAERRTCGGCRDGHCSPPAAGDPGPGAPAGPEAAAACNVIVNGTRGAAAEGAKSAEPPPEQPPPPPPPAPPKKLLSPEEPAVSELESVKENNCASNCHLDGEAAKKLMGEEALAGGDKSDPNLNNPADEDHAYALRMLPKTGCVIQPVPKPAEKAAMAPCIISSPMLSAGPEDLEPPLKRRCLRIRNQNK
What is the function of this protein?
Implicated in development of the cochlea.
What are the official names of this protein?
Sine oculis-binding protein homolog, Jackson circler protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOBP family.
Protein: HEY1_DANRE
Sequence: MKRNHDFSSSDSELDENIEVEKESADENAGANSPLGSMSPSTTSQVQARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHAAGGKGYFDAHALAMDYRGLGFRECLAETARYLSIIEGLDNTDPLRIRLVSHLNSYASQREAHSGLGHLAWGSAFGTPPSHLAHHLLLQQQQQQGAPLARSTSSPPSSNSSSPSSSSPSAPSTEPRLSGTVISEAGQTGPLRVPPSTSLPPGLTPPTASKLSPPLLTSLSSLSAFPFPLSAFPLLSPSSLGPATPSSSLGKPYRPWSMEIGAF
What is the function of this protein?
Transcriptional repressor which functions as a downstream effector of Notch signaling.
What are the official names of this protein?
Hairy/enhancer-of-split related with YRPW motif protein 1.
What is the protein family that this protein belongs to?
Belongs to the HEY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KGUA_BACTN
Sequence: MSTFSVFNFQFSIKQMTGKLIIFSAPSGSGKSTIINYLLTQNLNLAFSISATSRPPRGTEKHGVEYFFLTPEEFRCRIENNEFLEYEEVYKDRYYGTLKEQVEKQLEKGQNVVFDLDVVGGCNIKKYYGERALSIFVQPPSIEELRCRLTGRGTDEPEVIECRIAKAEYEMTFAPQFDRVIVNDDLEAAKAETLEVIKEFLNKE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AFFL_DROER
Sequence: MAQQQQQQLQQQQQHHTSSINNNNNSILLLQQQQPQQQQQLDQLQQYNNNLYSQNYNMEEYERRKRREREKIERQQGIQIDDRETSLFGEPRRVTEGDAEITAALGEFFEARVYINNQTVGISRSAPGAGNPRLQPNMPPQGKSLGHSPSSASASAAAGPTSASATTALPGQQQQHYQQQQRPPTYVKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRSSSSNSNSSSATNNASSGGVPASTPLGPPLSTQMPNGREKSFLGPPAPALHNGTGGRFVPPAASKRPGVGQQPPPPEKDVNKIISDIANIFTVQPLTLIAATPHAPTRENYNLLAPNKQKYAMDIPSSPPSAEPSSLMTPLFAPIASPIAPLVTTPPQASQLPLGGATSGTILAGEALAPLHQLPPTPPKAASGVTSPGPGKPLKTEKNHSLEKQDSCLENDLELSESEDEQRKKEGRSAGNSSNSSESDSSESGSESSSKNDPQHHPNHQQHHHQLQQQQQQQQQQASMQQQQVLQQQQQHRPQPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGSVGPAGLNSSAAMGAGSGSGGTLSSGGSSSNKTPSPTESNKWNLSRFFHKPANQTNSENVSPGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKIHDDHMAMEDGEEEDDDEEQQLRYGGGLSVTPVAVKKEAIDAVSEMALGAIPKTQIKRESAEALLSARLSDSGTSASGSSSSSSSSSDSAVGGEVVPKLGLGEILQLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQRQKKPRKKKAVTSAPILDSSDDDEPPPKHPGLDHTAVSVQTPPAADTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSVTAGSSSSDEDSSSSAESSSKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEPEDQTTRSQVGSGQALAQQLPPYKQLPISQHSQHLSSSECSSSSGGCTAVCSSSSGEEDEGRREKERERKPKSDKNKISTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPPPPQAPPAAPAAIMAKPRMTPTQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTPKDQATNAVHVPNGYAGDTNPATKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRDRERERERERERDREREQPPGRRRKRSSSSSSSPYKEKKRKKEKADQLQIGKELLPVPVLLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAANGSPTKKMMVMSPLPPPPTVTVAPATCNEAVQTTPPSATTASATAPPVPATRLIYRSYFDRDVEHPSDDPRKNNQFLQEAISRKHAADLERDSFNQVTLYLEAVVYFLLTADAMERCSSEQATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKVAILSLRCQSLISLKLYKLRRKDCRAVINSLADFFRVGRGDIANGNTPSSISPSNSVGSQGSGSNTPPGRIVPPDIHNMLCKENEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENGPLTLHSTMHEVFRYVQAGLKTLRDAVSHPTHQSQ
What is the function of this protein?
Has a role in transcriptional regulation.  Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth.  Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate.  Required specifically for the microtubule-based basal transport of lipid droplets.  Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye.  Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).
What are the official names of this protein?
AF4/FMR2 family member lilli, Protein lilliputian.
What is the protein family that this protein belongs to?
Belongs to the AF4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MZM1_KOMPG
Sequence: MSQASRALKAYRNALRATSVAFKNDVATLDAARNEIRTHMKSQEDPKGTNRSIDERLKLLDEVTVFLRHNIVQGRKVDEGKYRLNIHKDTELGDNDDIKKKKDGLSNGGFTGCCGGSGAKTT
What is the function of this protein?
Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex.  Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.  Modulates the mitochondrial matrix zinc pool (By similarity).
What are the official names of this protein?
Mitochondrial zinc maintenance protein 1, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the complex I LYR family. MZM1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: FOLD_BURMS
Sequence: MTATLIDGNALSKTLRAQAAERAAALAARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTCELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.