PharMolix/UniProtQA huggingface dataset:
Protein: REL_MELGA
Sequence: GISEPYIEIFEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNKTFPSIQILNYFGKVKIRTTLVTKNEPYKPHPHDLVGKDCRDGYYEAEFGPERRVLSFQNLGIQCVKKKDLKESISLRISKKINPFNVPEEQLHNIDEYDLNVVRLCFQAFLPDEHGNYTLALPPLISNPIYDNGAPNTAELRICRVNKNCGSVKGGDEIFLLCDKVQKDDIEVRFVLGNWEAKGSFSQADVHRQVAIVFRTPPFLRDITEPITVKMQLRRPSDQEVSEPVDFRYLPDEEDSYGNKAKRQRSTLAWQKLIQDCGSAVTERPKAAPIPTVNPEGKLIKKEPNMFSPTLMLPGLGTLASSSQMYPACSQMPTQPAQLGPGKQDTLHSCWQQLYSPSPSASSLLSMHSHNSFTAEVPQPGAQGSSSLPAYHDNPLNWPDEKDSSFYRNFGNTHGMGAALVSAADMQSVSSSSIVQGTHQASATAASIMNMETNDMNCTSLNFEKYTQMLNVSNHRQQLHQVPATCPPGSAWQHSLSSQPNVADRAVYSSF
What is the function of this protein?
Proto-oncogene that may play a role in differentiation and lymphopoiesis.  NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis.  NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52.  The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.  Different dimer combinations act as transcriptional activators or repressors, respectively.  NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors.  NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.  In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus.  The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity).
What are the official names of this protein?
Proto-oncogene c-Rel, p68.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTS_LEGPH
Sequence: MSTISAALVMQLRERTGAGMMECKKFLIATNGDIEQAIIEMRKAGQAKADKKADRVAAEGIIVIARSSDERTAVMLEINSETDFVARDENFTNFANAVADVALTSLPKNIEDLSNQALSSGATVEQARQELVAKIGENIKLRRLEKMHCDGVIGYYLHGSRIGVMVALKNGSEALAKDIAMHVAASKPMVVSRDQVPAEAIENEREIFTAQAKESGKPQEIIDKMIDGRINKFIDEVSLLGQPYVKDPNIKVGQLLKEKNAEVISFVRYEVGEGIEKKEDNFVEEVMAQVRT
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLOR_STRRC
Sequence: MSKALANMPGDDYFRHPPVFDTYAEHRAYLKFRHAVALRHFARLGFDQDGLAGLITVADPEHADTYWANPLAHPFSTITPADLIRVDGDSTETVDGQRRVNIAAFNIHAEIHRARPDVQAVIHLHTVYGRAFSAFARKLPPLTQDACPFFEDHEVFDDYTGLVLAKDDGRRIAKQLRGHKAILLKNHGLVTVGETLDAAAWWFTLLDTCCHVQLLADAAGGAEPIPAEVARLTGQQLGSHLLGWNSYQPLHEATLARNPDLAAMAPALPPQTPALAR
What is the function of this protein?
Involved in the biosynthesis of ring A of the aminocoumarin antibiotic clorobiocin (PubMed:12480894).  Catalyzes two consecutive oxidative decarboxylations of 3-dimethylallyl-4-hydroxyphenylpyruvate (3DMA-4HPP) to yield 3-dimethylallyl-4-hydroxybenzoate (3DMA-4HB) via the 3-dimethylallyl-4-hydroxymandelic acid (3DMA-4HMA) intermediate (PubMed:12777382).
What are the official names of this protein?
4-hydroxy-3-prenylphenylpyruvate oxygenase/4-hydroxy-3-prenylbenzoate synthase, Bifunctional non-heme iron oxygenase, Clorobiocin biosynthesis protein CloR.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family.
Protein: Y182_THEAC
Sequence: MSDVIMVNTEYIPGKRIVKVFGTIWGITVRSRGLGGNLVAGLRSLAGGEIKEYTKMLSDARNTAMERLQSAAEQIGANAVINVRFDSSDIGQVMTEIVAYGTAVLVEDVTDNIQRVGLS
What are the official names of this protein?
UPF0145 protein Ta0182.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: OSGL1_RAT
Sequence: MLMLSKTAGAIPRPPRSNVRGFIRRFNVQPRALFHHKLVLGIETSCDDTAAAVVDETGNVLGEALHSQTEVHLKTGGIVPPVAQQLHRENIQRIVEEALSASGVSPSDLSAIATTIKPGLALSLGVGLSFSVQLVNQFKKPFIPIHHMEAHALTIRLTHKVGFPFLVLLISGGHCLLALVQSVSDFLLLGKSLDIAPGDMLDKVARRLSLIKHPECSTMSGGKAIEHLAKEGNRFHFTINPPMQNAKNCDFSFTGLQHVTDKLITHKEKEEGIEKGQILSSAADIAAAVQHATACHLAKRTHRAILFCQQKNLLSPANAVLVVSGGVASNLYIRRALEIVANATQCTLLCPPPRLCTDNGIMIAWNGIERLRAGLGILHDVEDIRYEPKCPLGIDISREVAEAAIKVPRLKMTL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine.  Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Involved in mitochondrial genome maintenance.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, O-sialoglycoprotein endopeptidase-like protein 1, t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1, tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LEUC_KLEP3
Sequence: MAKTLYEKLFDAHVVYEAQNETPLLYIDRHLVHEVTSPQAFDGLRAHGRQVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCKEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIDVQGKAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGEAIRDLSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVRGRLHAPKGKDFDDAVAYWKTLKTDDGATFDTVVTLQAAEIAPQVTWGTNPGQVISVTDNIPDPASFSDPVERASAEKALAYMGLKSGIPLTDVAIDKVFIGSCTNSRIEDLRAAAEIAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRNLK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: TGS3_MYCTO
Sequence: MVTRLSASDASFYQLENTATPMYVGLLLILRRPRAGLSYEALLETVEQRLPQIPRYRQKVQEVKLGLARPVWIDDRDFDITYHVRRSALPSPGSDEQLHELIARLAARPLDKSRPLWEMYLVEGLEKNRIALYTKSHQALINGVTALAIGHVIADRTRRPPAFPEDIWVPERDPGTTRLLLRAVGDWLVRPGAQLQAVGSAVAGLVTNSGQLVETGRKVLDIARTVARGTAPSSPLNATVSRNRRFTVARASLDDYRTVRARYDCDSTTWC
What is the function of this protein?
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.  Required for storage lipid synthesis.
What are the official names of this protein?
Probable diacyglycerol O-acyltransferase tgs3, TGS3, Probable triacylglycerol synthase tgs3.
What is the protein family that this protein belongs to?
Belongs to the long-chain O-acyltransferase family.
Protein: DCVR_MAIZE
Sequence: MATILLSSRLPTTGTATPSPTRPAPRFLSFPGTAIRRRGRGPLLASSAVSPPAPASAAQPYRALPASETTVLVTGATGYIGRYVVWELLRRGHRVLAVARSRSGIRGRNSPDDVVADLAPAQVVFSDVTDPAALLADLAPHGPVHAAVCCLASRGGGVQDSWRVDYRATLHTLQAARGLGAAHFVLLSAICVQKPLLEFQRAKLKFEEELAAEAARDPSFTYSVVRPTAFFKSLGGQVDIVKNGQPYVMFGDGKLCACKPISEEDLAAFIADCIYDQDKANKVLPIGGPGKALTPLEQGEMLFRLLGREPKFIKVPIQIMDAVIWVLDGLAKLFPGLEDAAEFGKIGRYYASESMLLLDPETGEYSDEKTPSYGKDTLEQFFQRVIREGMAGQELGEQTIF
What is the function of this protein?
Catalyzes the conversion of divinyl chlorophyllide to monovinyl chlorophyllide.  Reduces the 8-vinyl group of the tetrapyrrole to an ethyl group using NADPH as the reductant.  Can use (3,8-divinyl)-chlorophyllide a (DV-Chlidea) > (3,8-divinyl)-chlorophyll a (DV-Chla) > (3,8-divinyl)-protochlorophyllide a (DV-Pchlidea) > (3,8-divinyl)-magnesium-protoporphyrin IX monomethyl ester (DV-MPE) > (3,8-divinyl)-magnesium-protoporphyrin IX (DV-Mg-Proto) as substrates.
What are the official names of this protein?
Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MESP2_HUMAN
Sequence: MAQSPPPQSLLGHDHWIFAQGWGWAGHWDSTSPASSSDSSGSCPCDGARGLPQPQPPSCSSRAAEAAATTPRRARTGPAGGQRQSASEREKLRMRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESLQCRRRQRGDAGSPWGCPLCPDRGPAEAQTQAEGQGQGQGQGQGQGQGQGQGQGQGQGQGRRPGLVSAVLAEASWGSPSACPGAQAAPERLGRGVHDTDPWATPPYCPKIQSPPYSSQGTTSDASLWTPPQGCPWTQSSPEPRNPPVPWTAAPATLELAAVYQGLSVSPEPCLSLGAPSLLPHPSCQRLQPQTPGRCWSHSAEVVPNSEDQGPGAAFQLSEASPPQSSGLRFSGCPELWQEDLEGARLGIFY
What is the function of this protein?
Transcription factor with important role in somitogenesis.  Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways.  Regulates also the FGF signaling pathway.  Specifies the rostral half of the somites.  Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand.  Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling.  Acts as a strong suppressor of Notch activity.  Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
What are the official names of this protein?
Mesoderm posterior protein 2, Class C basic helix-loop-helix protein 6, bHLHc6.
What are the subcellular locations of this protein?
Nucleus.
Protein: DDPS5_ARATH
Sequence: MLSLFSVVFTFLALFLIPGLFISRRLNVPLSLTNILRFIKIIASKYDDEEERNEKRGTMGEKQKRGRNIMPKHVAVILDGNRRWAEKRGLGTSEGHEAGARRLMENAKDCFAMGTNTISLFAFSTENWERPEDEVKCLMALFEKYLASDMPYLRSDKIKISVIGNRTKLPESLLGLIEEVEEATKSYEGKNLIIAIDYSGRYDILQACKSLANKVKDGLIQVEDINEKAMEKELLTKCSEFPNPDLLIRTSGEQRISNFFLWQSAYTELYFPTVLWPDFGEAEYLEALTWYQQRQRRFGRRV
What is the function of this protein?
Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein.
What are the official names of this protein?
Dehydrodolichyl diphosphate synthase 5, Dedol-PP synthase 5.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: CP341_MOUSE
Sequence: MNLFSALSLDTWVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYKGLWKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDSHKALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKVVPRDVVITGA
What are the official names of this protein?
Cytochrome P450 3A41.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: SFSA_SYNPW
Sequence: MTGTPLLSFEPLTEGILLKRYKRFLADIELEDGSCVTAHCANTGPMTGVLIPGQRVRLRHAPSPTRKLAWTWEQAEVPGADGQLCWVGINTALPNRLIRATIEAGCLREQLGEIESIRAEVVYGKNRKSRIDLLLQPSREAIDQRPIYVEVKNTTWSTGSTALFPDTVTTRGQKHLQELMDVLPEARAVLIPCLSRPDVTAFAPGDSADPRYGELFRNALDAGVEVLPCCFRFDRDGVTWQGTRPAQGQQPSAAL
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: HEM1_CHLL2
Sequence: MNIISVGVNHKTAPIEIRERIALSEVQNKEFITDLISSGLAHEAMVVSTCNRTELYVVPAMTEVTGEYLKEYLISFKDARKEVRPEHFFSRFYCGTARHLFEVSSAIDSLVLGEGQILGQVKDAYRIAAEVQAAGILITRLCHTAFSVAKKVKTKTKIMEGAVSVSYAAVELAQKIFSNLSMKKILLIGAGETGELAAKHMCQKNARNIVITNRTLSKAEALAEELGTGKVLPFESYKEYLHEFDIIITAVSTKEYVLREAEMHQSMQKRRLKPVIILDLGLPRNVDPDISRLQNMFLKDIDALKHIIDKNLEKRRGELPKVQAIIEEELVSFGQWINTLKVRPTIVDLQSKFIEIKEKELERYRYKVSEEELRRMEHLTERILKKILHHPIKMLKAPIDTSDSIPSRVNLVRNIFDLEEPNQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: NFYC_RAT
Sequence: MSTEGGFGSTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQTPQVTGD
What is the function of this protein?
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.  NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
What are the official names of this protein?
Nuclear transcription factor Y subunit gamma, CAAT box DNA-binding protein subunit C, CCAAT-binding transcription factor subunit C, CBF-C, Nuclear transcription factor Y subunit C, NF-YC.
What is the protein family that this protein belongs to?
Belongs to the NFYC/HAP5 subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL4_MYCBT
Sequence: MAAQEQKTLKIDVKTPAGKVDGAIELPAELFDVPANIALMHQVVTAQRAAARQGTHSTKTRGEVSGGGRKPYRQKGTGRARQGSTRAPQFTGGGVVHGPKPRDYSQRTPKKMIAAALRGALSDRARNGRIHAITELVEGQNPSTKSARAFLASLTERKQVLVVIGRSDEAGAKSVRNLPGVHILAPDQLNTYDVLRADDVVFSVEALNAYIAANTTTSEEVSA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RF1_ACIB5
Sequence: MKASLRLRLDQLCDRHEELTALLADAEVISDNKRFRKLSREHSDLTEITEVWGKYRQAEEDIETAEMMKSDPDFKDMAEEEIQANKVLLEELESQLNILMIPKDPNDSNAAYLEIRAGTGGDEAAIFSGDLFRMYSKYAESQGWRIEVLSENEGEHGGFKEVICRVDGDGVYGRLKFESGAHRVQRVPATESQGRVHTSACTVAILPEIDVDTNVEINPADLRIDTYRASGAGGQHINKTDSAVRITHIPTGTVVECQEERSQHKNKAKAMALLVSRLENAKRAAADAATSEMRRDLVGSGDRSERIRTYNYPQGRMTDHRINLTLYKLDAIMEGDLTELLDSLHREYQADQLAMLAQENGG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_STAHJ
Sequence: MDMQERYNRRENIRNFSIIAHIDHGKSTLADRILENTKSVETREMQDQLLDSMDLERERGITIKLNAVRLKYEANDGQTYTFHLIDTPGHVDFSYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLELLPVVNKIDLPAAEPERVKQELEDVIGLNQDDVVLASAKSNIGIEDILEKIVEVVPPPEGDPSEPLKALIFDSEYDPYRGVISSIRVMEGVVKAGDKIKMMATGKEFEVSEVGINTPKQLPIEELTVGDVGYIIASIKNVDDSRVGDTITHANRPAEAPLKGYKKMNPMVYCGLFPIENKDYNDLREALEKLQLNDASLEFEPESSQALGFGFRTGFLGMLHMEIIQERIEREFGIELIATAPSVIYQCIMKDGSEVTVDNPAQMPERDKIDSIYEPYVKATMMVPNDYVGAVMELCQRKRGQFINMDYLDDIRVNIVYEIPLSEVVFDFFDQLKSNTKGYASFDYEFIENKESNLVKMDILLNGDKVDALSFIVHKDFAYERGKALVEKLKTLIPRQQFEVPVQAAIGQKIVARTNIKSMGKNVLSKCYGGDISRKRKLLEKQKAGKAKMKAVGSVEIPQDAFLAVLKMDDE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TOLB_POLSJ
Sequence: MSITPSLSRRTVMSLLAAGLSPAFAQFRVEVSGVGLTQLPIAIASFRGEVQAPQKIGNIVRADLERSGMFRPVDTAGIVADENTRPDLAIWRQKGADAMVTGSVSPLADGRFDVRLRLWDIVRGQDLGGQSYTVAQADLRLSAHRISDFVYEKLTGEKGIFSTRIAYVTKTAQRFNLWVADSDGEGAQSALTSPEPIISPSWSPNGSQLAYVSFESRKPVIYAHDVATGKRRLLANFRGSNSAPAWSPDGKQLVATLSRDGGSQIYALGLSGGDPKRLTQSSSIDTEPAYSPDGRYIYFVSDRGGAPQIYRMSPGGGNPERVTFTGGYNISPAISPDGRWLAYVSRVGGAFKLHVMELASGTATPITDTTADESPSFAPNSRLIVYATQQQGREALMTTTLDGKIKARLSGAGGDIREPDWGPFQR
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LPXA_VIBCM
Sequence: MIHETAQIHPTSVVEEGAIIGANVKIGPFCFVDSKVEIGEGTELLSHVVVKGPTKIGRFNRIFQFASIGEACQDLKYAGEDTQLIIGDRNTIRESVTMHRGTVQDKGITIVGSDNLFMINAHVAHDCVIGDRCIFANNATLAGHVKVGNQAIVGGMSAIHQFCHIGDHCMLGGGSIVVQDVPPYVMAQGNHCAPFGINVEGLKRRGFDKAEIHAIRRAYKSLYRNGLTLEAAKAEIAQEAEQYPSVKLFLDFLEKSERGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_STRSV
Sequence: MRIADYSVTRAILERHGFTFKKSFGQNFLTDTNILQKIVDTAEIDKKVNVIEIGPGIGALTEFLAESAAEVMAFEIDDRLVPILADTLRDFDNVTVVNQDILKVNLAQYIAEFKNPDLPIKVVANLPYYITTPILMHLIESGIPFSEFVVMMQREVADRISAQPNTKAYGSLSIAVQYYMTAKVAFIVPRKVFVPAPNVDSAILKMVRRERPAVEVQDEKFFFKVSKASFVHRRKTLWNNLTSYFGKSEETKGKLTAALERAELSPSVRGEALSLEEFACLADALKSEGL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOCS3_ORYSJ
Sequence: MEGGGDDDGGRSRAEAIMRELERLRAEREELDGRIRLLESQLRLGAAPLPPSAAAEVEPTGSPSSSSSAAADMISRYRRHLLLPQFGLEGQRKLSQSSILVVGAGGLGSPVAMYLAACGVGCLGIVDGDRVELDNLHRQIIHIEAYVGQPKVKSTAASCRAYDIVVDATNNLPSRYMISDCCVLMNKPLISGSAVGLEGQLTVYHHNGSPCYRCLYPNPPSSPTSQSCSDNGILGILPGVIGCLQALEAIKVATAVGKPLCGRMLHFDALSSHTRIVKISRSSPTCKVCGENPVFTKEDFVNFDYESFTQSPMSKNSTTRSLNLLPENARVSCRDYKKVLDSGRPHLLVDVRPSHHFQIASMAHSINVPLSLLEEKLPLLRDSAREVSSRRDGRQHCPVYVICRRGNDSQVAVQILRENGFLYASDVAGGFESWAKEVDPSFLLY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Also essential during biosynthesis of the molybdenum cofactor.  Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A.  Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase MOCS3, Molybdenum cofactor synthesis protein 3.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_LEVBA
Sequence: MDLEKLKNHQKYIRNFSIVAHIDHGKSTLADRILELTDTISKRDMQDQVLDDMDLERERGITIKLNAVELTYHAKDGHDYEFHLIDTPGHVDFSYEVSRSLAACEGAVLVVDAAQGVEAQTLANVYLALDDDLEIVPVINKIDLPAADPDKVKNEIEEVIGLDASDAVLASAKQGIGIPELLEQIVTKIPAPAGDLAAPLKALVFDSVYDDYRGVVLSIRLFEGTVKPGDKIRLMNSGSEYEVTEVGVNSPKPIARDYLIAGDVGYITASIKDITDTRVGDTVTSADQPADKALPGYREMSPMVYAGLYPTDNAKLNDLREALEKLQLNDAALEFEPESSQALGFGFRCGFLGMLHMDVIQERLEREFNLDLITTAPSVTYHAYLTDGTMKEVENPAEMPEASAIKRIEEPIVKATIMAPNDYVGAVMDLCQHRRGQFLTMEYLDDYRVNIIYNMPLSEIIFDFFDKLKSNTRGYASLDYEMNGYQGADLVKIDILLNGDKVDALSFIAHRTFAPARGREIASRLKKIIPRQNFEIPVQAAIGAKIIARTTIKAYRKDVTAHLYGGDRTRRMKLLEKQKAGKKRMKAVGKVDIPQEAFMAVLQTDEDETK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.