PharMolix/UniProtQA huggingface dataset:
Protein: ATG1_YARLI
Sequence: MSSIKSYTIGNELGRGSFATVYKGEHVASGSPVAIKSVLRAKLNRKLLENLGSEISILKQMKHPHVVELLDFQETPTHFHLVMEYCSLGDLSFFLKKKKELSETLPLVASLLRRYPSNTRGLHEELVRHFVHQLSAALEFLRQKNLVHRDIKPQNLLLCPPSLSEMDAQNANLYGRWELPILKIADFGFARILPASALAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVTYEMVVGKPPFKANNYVELLKTIEQSNDVIGFGREPPSEDMQDFVRCLLKKNPADRIGFKEYFEHPIIANKQVIGSGEELDRSQLDPRMYISEYIQEADLPKLDLDREMDSFSQKRSTQKSSPKNSTNKTLSSTVKNPLLELTSPSPGSSLLLTRKNESLFLESEYVVVEKRQVEVNTLADELAREPDERRPSSERRFSLTYGAPTGAMARALSMASARLLGEKKNGAGHGSGNGSRNGSGNGSGNGARLSAGAALSGTSSGTSTTGKSPPVPATTTPSLSEREIVETLEEIAAKARSIALLADVKYSQIQDDVDNPDMNLPDSVSSSIAEEAMLLYVKTLSLLSLAMDQAGAWWSNNHKDNKMVSSHFNEIIQWTRSAFNESLERAETVKKKVSSGTTHTTAEKLIFDRALEMSRDAAVQEISGDFTGCESAYTTSIWMLEALLEDDEDGLGEEDRRIVERFISSITKRLVILRGQQE
What is the function of this protein?
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes.  Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates.  Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.  Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
What are the official names of this protein?
Serine/threonine-protein kinase ATG1, Autophagy-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
Protein: TTF17_HADVE
Sequence: EQCGDDVCGAGHCCSEYPPMHCKRVGQLYDLCMASKATKNSGNHLFFCPCDEGMYCDMNSWSCQKRTA
What are the official names of this protein?
U1-hexatoxin-Hv1a, U1-HXTX-Hv1a, Atracotoxin-Hvf17, AcTx-Hvf17.
What is the protein family that this protein belongs to?
Belongs to the MIT-like AcTx family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS15_CORGL
Sequence: MALTSEQKKSILSEFGLHETDTGSPEAQIALLTNRINNLTEHLKFHKHDHHSRRGLLLLVGRRRGLLKYLADNNVDRYRDLIARLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RPOB_STUS1
Sequence: MAYSYTEKKRIRKDFSKLPHVMDVPYLLAIQLDSYREFLQAGATKDQFRDIGLHAAFKSVFPIISYSGNAALEYVGYRLGEPAFDVKECVLRGVTFAVPLRVKVRLIIFDKESSNKAIKDIKEQEVYMGEIPLMTENGTFIINGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDAVFVRIDRRRKLPASVLLRALNYSTEEILDAFYDTNVFHVKGETLALELVPQRLRGEIATFDIKDDSGKVIVEQGRRITARHINQLDKSGIKELEMPMDYVLGRTVAKAIVHPATGEIIAECNTELTVDVMAKIVKAQVVRFETLYTNDIDCGPFISDTLKIDSTTNQLEALVEIYRMMRPGEPPTKDAAETLFNNLFFAAERYDLSAVGRMKFNRRIGRTEIEGSGVLSREDIVAVLKTLVDIRNGKGIVDDIDHLGNRRVRCVGEMAENQFRVGLVRVERAVKERLSMAESEGLMPQDLINAKPVAAAVKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLAAYARTNQYGFLESPYRVVKDGEVTDEIVFLSAIEEADHVIAQASAKLDGRKLVDELVAVRHLNEFTVKAPEDVTLMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRSDKPLVGTGMERNVARDSGVCVVARRGGVIDSVDASRIVVRVRDDEVETGEAGVDIYNLTKYTRSNQNTCINQRPLVRKGDVVARGDIMADGPSTDMGELALGQNMRVAFMPWNGYNFEDSILLSERVVQEDRFTTIHIQELTCVSRDTKLGPEEITADIPNVGEAALNKLDEAGIVYVGAEVGPGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPTGTKGTVIDVQVFIRDGVERDSRALAIEKMQLDEIRKDLNEEFRIVEGATFERLRSALVGATAEGGAGLKKGVVITDEILDGLEHGQWFKLRMAEDALNEQLEKAQAYLSDRRQLLDDKFEDKKRKLQQGDDLAPGVLKIVKVYLAIKRRIQPGDKMAGRHGNKGVVSVIMPVEDMPHDANGTPVDIVLNPLGVPSRMNVGQILETHLGLAAKGLGEKINLMLEEQRKVAELRKFLHEIYNEIGGRQENLDDLSDQEVLDLANNLRKGVPMATPVFDGAKEREIKAMLKLADLPESGQMQLFDGRTGNAFERTTTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEAGMPESFNVLIKEIRSLGIDIDLETE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: KGP_TOXGO
Sequence: MGACISKNSSARVSRSSALSASKQTVAASAPPGAAGDETSATGAAEEASRNSLARVDGTRASAAELERAPDGVCPDREEPGTANAEQGGVTEKKDTRETLAGMNSPKTLEAEAQEDDPKREAPNQDVPSEAPEGPKEKPGGDRKPAQKAILKQDDSHTEEEKLNAHLAYREKTPADFALIQDSLKANLVCSSLNEGEIDALAVAMQFFTFKKGDVVTKQGEPGSYFFIIHSGTFDVLVNDKRVNAMDKGKAFGEIALIHNTERSATVVASSTEGALWGVQRHTFRETLKQLSSRNFAENRQFLASVKFFEMLTEAQKNVITNALVVENFKPGQPIVKEGDAGDVLYILKSGKAKVSIGGREIRMLRKGDYFGERALLYKEPRSATITAEEFTVCVSIGRELLDRVLGNLQHVLFRNIMVEALQQSKVYELFQGDQLSKLIEAAVVKDYGADYVILDKENKTKGIRFFFVLEGELSVYAYTQNPATKEEERKLAATLKRGQAFGEEYVLNPTRPFNHYVKSVGPCKLALFTSSVLTATLGGEDIDETLDFNNKRAIIRKMYIFRYLSDHQMTMLIKAFKTVRYMSGEYIIKEGERGTRFFIIKAGEVAILKNNKRLRTLGRHDYFGERALLYDKPRTASVCANSAGVDLWVVDKSVFNEIIKGPMLAHLEERIRMQDTKVEFQDLQVVRVVGRGTFGTVKLVRHVPTDIRYALKCVSRRSVIALSQQQHIRLEREIMAENDHPFIIRLVRTFRDKEFLYFLTELVTGGELYDAIRKLGLLARSQAQFYLASIVLAIEYLHERNIAYRDLKPENILLDSQGYVKLIDFGCAKKMQGRAYTLVGTPHYMAPEVILGKGYTLTADTWAFGVCLYEFMCGPLPFGNDAEDQLEIFRDILTGKLVFPHYVTDQDAINLMKRLLCRLPEVRIGCSINGYKDIKEHAFFGDFDWDKLAGRGLPPPLAPKGETYAEDTEQSSFELDEDDTIVLEDEYDWDKDF
What is the function of this protein?
Dispensable for parasite invasion of and egress from host cells, and microneme secretion.
What are the official names of this protein?
cGMP-dependent protein kinase, TgPKG.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Lipid- anchor. Note=Membrane localization is essential to regulate parasite invasion, egress and microneme secretion. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: GCY36_CAEEL
Sequence: MFGFIHESIRQLMIRTYGEAFWSKVLERAGFEAGKENIINHYYSDADTFSLVDAVSVILKVTREQVWEMYGCFLIQYTMETGWDDLIRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEDNPDGTITLHYYTGRPGLYPIVKGVLREAAKRVFKLDVSMTITGRTQRSVQMATGERIEEHVIFLVKTLNTDQSNEEALGTAVVQHSNNYKIRLTHMDFISTFPYHMVVDQDCKIVQVGRELYNHIPKDLLSVGTPLMRIFEVTRPQIPLDFDSICNFINAVFVLQVKTTPMEFQRNANKRAAQAIEASENLYEDNNGALALSQSQHLKLKGQMMLMSSGGHIMYLCSPYVTSIPELLQYGLRLTAMPIHDPTRDLILLNQQRLSDVEMNLQLEANNEQLENMAKDLEVEKGKTDALLREMLPPSVAQQLKQGLSVEAREYEEATVMFTDVPTFQQIVPLCTPKDIVHLLNELFTKFDRLIGIQKAYKVETVGDSYMSVGGIPDLVDDHCEVICHLALGMVMEARTVCDPITNTPLHIRAGIHSGPVVAGVVGAKMPRYCLFGDTVNTSSRMESHSPIGRIHCSENAKKCAESTGRFEFEPRGRVQIKGKGEMNTYFLLRSFKRSIWEIIDRRRDENCNSIDGYNELREGYVDDVLNKVTQKNSKTCSIS
What is the function of this protein?
Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP.  Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity.  cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation.  Indeed, C. elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior.  Involved in avoidance of hyperoxia and for oxygen-induced aggregation and bordering, probably by mediating oxygen sensing in URX, AQR and PQR sensory neurons.
What are the official names of this protein?
Soluble guanylate cyclase gcy-36.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBP1_MOUSE
Sequence: MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKTSEYRGSEIDQVVPAAQSSPVSCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKTGVKHLFNIISRKKEALKDDSNQKDKGSCKEESLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGFLQHDAQEVLQCILGNIQETCQLLKKEEIKNLAELSGKVEEQSLQKEETGGITSTEIDSMRNTEDVKEQLPKGNWKRKSDSESSNVKKKVKLSRESQPLEENQRQTRSKRKAIGDTLEAAPKIIPKCVSESESAKPSQKKSKVKINWLKPSTKQPSILSKFCSLGKITTNQRSKGQPKEKEGDVEEDLEKYGSDHTANGGPESPGSSVTPVDSSEAKSGNKGAEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDEGNFVVDQMCELGKPEPLTEEQARGTAGNYDDEVSIRVGGNAQPSKVLNKKNVEGIGLLGGQKSKADYELYNKASNPDKVVGTPFTDNRNSETNDTTNGTHESDRNKESSDQTGVNMNGLENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL
What is the function of this protein?
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2.  Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA.  Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 1, Deubiquitinating enzyme 1, Ubiquitin thioesterase 1, Ubiquitin-specific-processing protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PIGU_HUMAN
Sequence: MAAPLVLVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQIAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITLTFNVGQILLISDYFYAFLRREYYLTHGLYLTAKDGTEAMLVLK
What is the function of this protein?
Component of the GPI transamidase complex.  May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
What are the official names of this protein?
Phosphatidylinositol glycan anchor biosynthesis class U protein, Cell division cycle protein 91-like 1, Protein CDC91-like 1, GPI transamidase component PIG-U.
What is the protein family that this protein belongs to?
Belongs to the PIGU family.
Protein: S35B4_MACFA
Sequence: MRPALAVGLVFAGCCSNVIFLELLARKHPGCGNIVTFAQFLFIAVEGFLFEADLGRKPPAIPIRYYAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLIANMILGIIILKKRYSIFKYTSIALVSVGIFICTFMSAKQVTSQSSLSENDGFQAFVWWLLGIGALTFALLMSARMGIFQETLYKQFGKHSKEALFYNHALPLPGFIFLASDIYDHAVLFNKSELYEIPGIGVTLPIMWFYLLMNIITQYVCIRGVFILTTECASLTVTLVVTLRKFVSLIFSILYFQNPFTLWHWLGTLFVFIGTLMYTEVWNNLGTTKSEPQKDNKKN
What is the function of this protein?
Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar.  May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics.
What are the official names of this protein?
Nucleotide sugar transporter SLC35B4, Solute carrier family 35 member B4, UDP-xylose and UDP-N-acetylglucosamine transporter.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: CYOE1_PSEP1
Sequence: MATLLSVRRARWRDYLELTKPKVVVLMLITSLAGMFLATRAGVSWSVLLFGNLGIGLCAGGAAVVNHVVDRRIDALMARTHKRPLAQGRVEPLPALLFALALALLGMVLLLVFTNALTAWLTLASLLGYAVLYTGFLKRATPQNIVIGGLAGAAPPLLGWVAVSGHVSAEPLLLVLIIFAWTPPHFWALAIHRKEEYAKADIPMLPVTHGERYTKLHILLYTLILLAVSLLPYAIHMSGPLYLACALGLGLRFLHWAWVLYRSSRPHAAIGTFKYSIGYLFALFIALLLDHYLLLSL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase 1, Heme B farnesyltransferase 1, Heme O synthase 1.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS18_BACSU
Sequence: MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKILPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18, BS21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: CYB_NOCLE
Sequence: MTNLRKSHPILKIINSSLVDLPVPVSISSWWNFGSLLMACLAVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWIIRYLHANGASMFFICLYLHIGRGLYYGSYLYSETWNIGILLLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIIAALAMVHLLFLHETGSNNPTGIPSDTDMIPFHPYHTIKDILGLMLMLSVLSALVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLAVIPFLHTSKQRSMMFRPLSQCLFWILTSDLLILTWIGGQPVEHPYIIIGQVASIMYFTIILIIMPLTSLLENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y780_METJA
Sequence: MKGIFEKLKRRIDILLYKLGIRPLSIETLKELKESRKEREVLEFYDVYMEPEEFVDIEKYEFILYEGDIVGKTAESLSKIFKGNLFPSRNELRYMGVKDEVAYFKKVVIYMIITFLALLFMGLLDNNLLQGFVNGLIGAGIILVLSLFYPKIRLILFKGEIKLQILFTLIYMISILRAGASLPEVLESISKSREYGVVAFEAKSIIRDVNIGGYNLVEALERAKMRTRIPILKKLYDQMIVGYNKGNLPLLLGKLYEDIVRESMVKLDSSKFMIQNLGNLAFGVGLILPFTGMILSTMIGNQGFSGILSTINLLLLKIGPLLTLIFGIFVKLKIE
What are the official names of this protein?
Uncharacterized protein MJ0780.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUTL_SALPB
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEDIAPAPRHVPENRIAAGRNHFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQPGYQKQQGEVYRALLQTPTTSPAPEAVAPALDGHSQSFGRVLTIVCGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQSPVCAQPLLIPLRLKVSADEKAALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: TYSY_MYCA1
Sequence: MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELVLAHRDSIFDYTYDDVVVHNYDPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAP_I68A6
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYKRVDGKWMRELVLYDKGEIRRIWRQANNGDDATAGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGPAVASGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACNSAAFEDLRVLSFIRGTKVSPRGKLSTRGVQIASNENMDAMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPAFSVQRNLPFDKPTIMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEMSFQGRGVFELSDEKAANPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: FIMF_ECOLI
Sequence: MRNKPFYLLCAFLWLAVSHALAADSTITIRGYVRDNGCSVAAESTNFTVDLMENAAKQFNNIGATTPVVPFRILLSPCGNAVSAVKVGFTGVADSHNANLLALENTVSAASGLGIQLLNEQQNQIPLNAPSSALSWTTLTPGKPNTLNFYARLMATQVPVTAGHINATATFTLEYQ
What is the function of this protein?
Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae).  Involved in the integration of FimH in the fimbriae.
What are the official names of this protein?
Protein FimF.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: YSMU_CAEEL
Sequence: MVQRVVVSKLLNSSRPLVFGMIHVPALPGTPSNTLPMSAILKKVRKEADVYFKNGVDGVIVENMHDVPYVKPPASPEIVSSMALASDQLVKSRDAHHPAALTGIQILAAANREALAVAYTTGMDFIRAEGFVYSHVADEGWIDGCAGGLLRYRSSLKAENIAIFTDIKKKHSAHSVTSDVSIHEMAKDAKFNCADGVIVTGSATGSAASLEEMIQVMKVQEFPVLIGSGINGKNAREFVKAHGFIVGSDFKIGGEWKNDLDSGRISKFMKHVNTLKR
What are the official names of this protein?
Uncharacterized protein F13E9.13, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the BtpA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CDC42_MACFA
Sequence: MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFNNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
What is the function of this protein?
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.  In active state binds to a variety of effector proteins to regulate cellular responses.  Involved in epithelial cell polarization processes.  Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase.  Regulates cell migration.  In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity).  Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons.  Facilitates filopodia formation upon DOCK11-activation (By similarity).  Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity).  Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity).
What are the official names of this protein?
Cell division control protein 42 homolog.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome. In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells.
Protein: SLYX_PROMH
Sequence: MDIKEIEELLIQLESKIAFQDATIEELNQVVTQQQIEISRFKEALKIVTERLKSSQSSMLARPEDETPPPHY
What are the official names of this protein?
Protein SlyX.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: RK4_NEOYE
Sequence: MTVNTQLNYQVYNWEGQVSGNADLNLKVSQDSGMYLVHRALVKQSNEKRQGSANTKTRSEVRGGGRKPWRQKGTGRARAGSIRSPLWRGGGVIFGPKPRSFTKKMNKKERQLALRTALNNKSVNTLIVENFNSYFHQPKTKLFMEAIHRWNLDLNKKVLVIVDKKDPNVYLSIRNLHNVELISADTLNIMALLAAHKIIITVDALSKIQEVYNG
What is the function of this protein?
Probably binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.