Protein: TTP_MOUSE
Sequence: MDLSAIYESLQSMSHDLSSDHGGTESLGGLWNINSDSIPSGVTSRLTGRSTSLVEGRSCGWVPPPPGFAPLAPRPGPELSPSPTSPTATPTTSSRYKTELCRTYSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPTEDLALPGQPHVLRQSISFSGLPSGRRSSPPPPGFSGPSLSSCSFSPSSSPPPPGDLPLSPSAFSAAPGTPVTRRDPNQACCPSCRRSTTPSTIWGPLGGLARSPSAHSLGSDPDDYASSGSSLGGSDSPVFEAGVFGPPQTPAPPRRLPIFNRISVSE
What is the function of this protein?
Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10706852, PubMed:10805719, PubMed:15014438, PubMed:15187092, PubMed:15634918, PubMed:17030620, PubMed:19188452, PubMed:20595389, PubMed:21078877, PubMed:22701344, PubMed:27193233).  Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:21278420).  Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:21278420).  Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:21278420).  Self regulates by destabilizing its own mRNA (PubMed:15187092, PubMed:17288565).  Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:11533235, PubMed:15187092, PubMed:16508014, PubMed:17288565, PubMed:17971298, PubMed:20595389, PubMed:21078877, PubMed:21278420, PubMed:22701344, PubMed:27193233).  Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (PubMed:8630730, PubMed:9703499, PubMed:15014438, PubMed:16514065).  Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (By similarity).  Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (By similarity).  Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344).  Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (By similarity).  Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (PubMed:25815583).  Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (By similarity).  Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (By similarity).  May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (By similarity).  Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (By similarity).  In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (PubMed:22844456).  Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (PubMed:22844456).  Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811).  Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (By similarity).  Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (By similarity).
What are the official names of this protein?
mRNA decay activator protein ZFP36, Growth factor-inducible nuclear protein NUP475, TPA-induced sequence 11, Tristetraprolin, Zinc finger protein 36, Zfp-36.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (PubMed:11796723, PubMed:11886850). Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (PubMed:11886850, PubMed:16508015). Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm (By similarity). Component of cytoplasmic stress granules (SGs) (PubMed:15967811). Localizes to cytoplasmic stress granules upon energy starvation (PubMed:15014438). Localizes in processing bodies (PBs) (By similarity). Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (PubMed:15014438). Shuttles in and out of both cytoplasmic P-body and SGs (PubMed:15967811).