PharMolix/UniProtQA huggingface dataset:
Protein: SORC2_MOUSE
Sequence: MAHRGPPSAPKRPGPTAPDRSFQALLPPCWPRSWPLLLLLLVLVAACGAMGRSPQPGRQGPGVQITRLLPAGRTESGDRKDPQARESEPSVPGLGPGSASGPSTDGAPAPGKGRRARAVPVAGAASASRAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTTYTKLTLQPGVTTVIDNFYICPANKRKIILVSSSLGDREQSLFLSTDEGATFQKYPVPFLVEMLLFHPKEEDKVLAYTKDSKLYVSSDLGKKWTLLQERVTKDHVFWAVSGVDDDPNLVHVEAQDLSGGYRYYTCLIYNCSAQPHIAPFSGPIDRGSLTVQDEYIFLKATSTNRTKYYVSYRRSDFVLMKLPKYALPKDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLENVRSSRQAEENVVIDILEVRGVKGVFLANQKVDGKVTTVITYNKGRDWDYLRPPSTDMNGKPTNCQPPDCYLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAAIKDTSIPLKILKFSVDEGHTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFRPSFPRQCGEDDYSSWDLTDLQGDHCIMGQQRSYRKRKSTSWCVKGRSFTSALTSRVCKCRDSDFLCDYGFERSSSSESTANKCSANFWFNPLSPPEDCVLGQTYTSSLGYRKVVSNVCEGGVDLQQSPVQLQCPLQAPRGLQVSIRGEAVAVRPREDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHHYESPGIYRVSVRAENMAGHDEAVLFVQVNSPLQALYLEVVPVIGVNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTKFTDAGDVRVTVQAACGNSVLQDSRLVRVLDQFQVVPLRFSRELDTFNPNTPEWREDVGLVVTRLLSKETSIPEELLVTVVKPGLPTIADLYVLLPLPRPTRKRSLTSDKRLAAVQQALNSHRISFILRGGLRILVELRDTDTGPQRPGGSGGYWAVVVLFVIGLFAVGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDAQSTMQGNHSGVVLSINSREMHSYLVG
What is the function of this protein?
The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994).  ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487).  Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994).  Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994).  Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:29909994, PubMed:27457814).  Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814).  ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity).  Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074).  Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898).
What are the official names of this protein?
VPS10 domain-containing receptor SorCS2.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family. SORCS subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane. Recycling endosome membrane. Synapse, synaptosome. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Synapse. Postsynaptic density membrane.
Protein: RSMA_STRZJ
Sequence: MRIADYSVTKAVLERHGFTFKKSFGQNFLTDTNILQKIVDTAEIDDQVNVIEIGPGIGALTEFLAERAAQVMAFEIDHRLMPILADTLRDFDNVTVVNEDILKVDLAQHIQNFKNPNLPIKVVANLPYYITTPILMHLIESGIPFCEFVVMMQKEVADRISAQPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRPEPAVAVEDENFFFKVSKASFTHRRKTLWNNLTGYFGKTEEVKDKLTKALDQAGLSPSVRGEALSLAEFAGLADALKGQGL
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_VEREI
Sequence: MNALETQGLGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVSAGMAIFDTMNFIKPDVSTLCTGMAASMGAFLLAAGAKGKRFALPNSKVMIHQPLGGMQGQATEIEIHAREILKTREQLNKILAERTGQPLEKIQRDTERDYFLSADESREYGLVDQVIHRRS
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS24_HALMA
Sequence: MDIDIIEEDENPMLHRTDVRFEVVHDEATPSRLSVRDSLAATLNKDAEEVVIHKLDTKFGMRKTVGYAKVYDNPEYARDVEQDHMLERNKIVADGEEEAEEA
What are the official names of this protein?
30S ribosomal protein S24e, E1.2, HS15.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: CRIF_ASPCR
Sequence: MQPFHTLSRILPFPDATQKAWWDKLAPMLLKAMQAQGYDTEAQYAQLGMVYKCVLPYLGQYPTVENDATRWKSFLCPYGIPIEPSLNISQGILRYAFEPIGPDVGTDKDPQNMNVIQDCLKGLTDHDDRIDTTLYAQFASRLLLTKEESQRVAATGQFTFKPGQGMHGYAVDMKGSQPMVKGYFCVGIKSAVTGIPTGKLMLDAVREVDTEGRITEPLDKLEDYYGNALGNLRLCFMSVDMIDPQDARTKLYGLQQEVSFEGLEDLWTLGGRINTPTNQEGLQLLRELWDLLQIPPGVRDIEVDHCSVGQPPKYLLPSLVNWTFLPGHSDPMPQVYLVPFGLPDAHISDALVTFFERRGWTDLARSYKSNLASYFPDVDFSQSRHVQEAISFSFRKGKPYLSVYMSLF
What is the function of this protein?
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of echinulin family alkaloid (PubMed:35843946).  The pathway begins with the biosynthesis of the cyclic dipeptide cyclo-L-Trp-L-Ala (cyclo-TA) by the NRPS criC via condensation of L-alanine and L-tryptophan (PubMed:35843946).  The prenyltransferase criA then catalyzes the first prenylation step, a reverse prenylation reaction at C2, to yield preechinulin (By similarity).  Preechinulin is the substrate of the cytochrome P450 monooxygenase criE that catalyzes the formation of the double bond between C10 and C11 to produce neoechulin A (By similarity).  The unique prenyltransferase criF functions as a competitive enzyme with criE for preechinulin metabolization and uses preechinulin for effective regiospecific prenylations.  Preechinulin is prenylated by criF at C5 or C7.  C7-prenylation leads to accumulation of tardioxopiperazine B without further modification by criF.  In contrast, the C5-prenylated tardioxopiperazine A can be prenylated again by criF, predominantly at C7 to form echinulin or less frequently at C4 to give variecolorin L.  CriF accepts also neoechilunin A to produce varlecolorin G (prenylation at C5) or isoechinulin A (prenylation at C7).  CriF further converts isoechinulin A into dehydroechinulin.  Moreover, a yet unidentified enzyme can also convert neoechilunin A into neoechilunin B by introducing a double bond between positions C14 and C17 and thus provides a further substrate to criF for C5 and C7 prenylation (By similarity).
What are the official names of this protein?
Prenyltransferase criF, Echinulin biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: ATP6_LUMTE
Sequence: MMPDIFSSFDPYMFNTLFPLNSLFLVTNTAIILMIQSSFWVLNARTSAFKSPVNDTIFTQLSRTSTTHLKGLSTPLSTIFFMLVMINLMGLIPYMFSTSSHLVFTLSLGFPIWLSLMISTFAHSPKKSTAHFLPDGAPDWLNPFLVLIETTSVFVRPLTLSFRLAANMSAGHIVLSLMGIYCAAAWFSSVSSTALLILTAIGYILFEVAICLIQAYIFCLLLSLYSDDHAH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TLR4_MOUSE
Sequence: MMPPWLLARTLIMALFFSCLTPGSLNPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT
What is the function of this protein?
(Microbial infection) Required for the virulence of fungus C. neoformans var.  grubii serotype A (strain KN99) CPL1 (PubMed:35896747).  Independently of Ly96/Md2, activated by CPL1 which results in a type 2 inflammation response characterized by Arg1/arginase-1 induction in interstitial macrophages (PubMed:35896747).
What are the official names of this protein?
Toll-like receptor 4.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation.
Protein: JAL5_ARATH
Sequence: MSWDDGKHTKVKRVQLTFDDVIRSIEVEYDGTSLKSQPRGTAGTKIDGFTLSSDEYITEVNGYYKTTFSGEVITSLTFKTNKRTYGTYGNKTSSYFSVAAPKDNQIVGFLGSSSHALNSIDAHFAPAPPPGSTGAKPGASGIGSDSGSIGSAGTNPGADGTRETEKNAGGSKPSSGSAGTNPGASAVGNGETEKNAGGSKPSSGSAGTNPGASAGGNGETEKNVGGSKPSSGKAGTNPGANAGGNGGTEKNAGGSKSSSGSARTNPGASAGGNGETVSNIGDTESNAGGSKSNDGANNGASGIESNAGSTGTNFGAGGTGGIGDTESDAGGSKTNSGNGGTNDGASGIGSNDGSTGTNPGAGGGTDSNIEGTENNVGGKETNPGASGIGNSDGSTGTSPEGTESNADGTKTNTGGKESNTGSESNTNSSPQKLEAQGGNGGNQWDDGTDHDGVMKIHVAVGGLGIEQIRFDYVKNGQLKEGPFHGVKGRGGTSTIEISHPDEYLVSVEGLYDSSNIIQGIQFQSNKHTSQYFGYEYYGDGTQFSLQVNEKKIIGFHGFADSHLNSLGAYFVPISSSSSSLTPPPNKVKAQGGSYGETFDDGAFDHVRKVYVGQGDSGVAYVKFDYEKDGKKETQEHGKMTLSGTEEFEVDSDDYITSMEVYVDKVYGYKSEIVIALTFKTFKGETSPRFGIETENKYEVKDGKGGKLAGFHGKASDVLYAIGAYFIPAAN
What are the official names of this protein?
Jacalin-related lectin 5.
What is the protein family that this protein belongs to?
Belongs to the jacalin lectin family.
Protein: ARLY_BACCR
Sequence: MSKLWGGRFTEEAEAWVEEFGASISFDQQLVNQDINGSMAHVTMLAKQGIVTQEEAEKIKIGLQYLLKEAKENKLQFSVEAEDIHLNIEKMLIEQIGEVGGKLHTGRSRNDQVATDMHLYLKEKVEHIIKATKQLQTVLVQQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTTFPIDREYSAELLGFNGIYENSLDAVSDRDFILEFLSNSSMLMMHLSRFCEELILWSSQEFQFIEMSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVKTVEGCLHIMTGMLETMTVNKEKMGQAVTQDFSNATEIADYLANKGLPFRQAHEIVGKLVLYCTQKGIYLLDVSLETYKEMSSLFEEDLYEVLSPYAAVKRRNSAGGTGFEQIKNALEKAKGLTKEVIKN
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB6_SOYBN
Sequence: MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFASVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTASFGVTGYSLPWDQIGYWAVKIVTGVPDAIPVIGSSLVELLRGSSSVGQSTLTRFYSLHTFVLPLLTAVFMLMHFSMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PAX_I82A4
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGENPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFVSPREAKRQLKKDLKSQEPCAGLPTKVSHRTSPALKTLEPMWMDSNRTAALRASFLKCQKK
What is the function of this protein?
May play a role in the modulation of host immune response.
What are the official names of this protein?
Protein PA-X.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA-X family.
Protein: FBK69_ARATH
Sequence: MSDNNPEIESSTFNNLNIDVTESILYHLPIPSLVRFTLVSKQWRSLITSLPPSPSPSPSSPPWLFLFGIHNTSSFHNQSFAFDPLSNTWLRLPPSSSSSDHLVGSNRFLFTTAPRFSFSPILKPNWRFTSPVRFPRINPLLTVFTTLSNSSKLILVGGSSRIGGLVDIEERLAVQIYDPVLDSWELCSPLPADFRSGQDHQTLTSALFKRRFYVFDNYSCFISSFCLDSYTWSDVQTLKPPGLSFAYLNSCNGMLVLGGMCGFSFNLWSIEEGSMEFSEIAVMPEDLLFGLVDSDDEDDKFRSLKCAGSGNLVYVFNDDCHKKFPACVCEIGGGENGICSWRRVPCLPSPVNKFHKVVSFCSTVSITDVFHPEEARIGGSIRG
What are the official names of this protein?
F-box/kelch-repeat protein At3g24760.
Protein: UGTP1_CAEEL
Sequence: MKFQNVHISHQDEDKEKLLPNDKDVEKADESPSSSRPSFVFKCYVIASMTFIWTAYTLTIKYTRSTVNPDMMYSSTSVVLCAEILKLVITFAMFYKECNFDSRQFSEQVSKYYINAPRELAKMSVPSFAYALQNNLDFVGLSNLDAGLYQVTTQLKVVSTAFFMMLFLGRKFSTRRWMAITLLMFGVAFVQMNNVSASEANTKRETAENYIVGLSAVLATCVTAGFAGVYFEKMLKDGGSTPFWIRNMQMYSCGVISASIACLTDFSRISDKGFFFGYTDKVWAVVILLGVGGLYISLVMRYLDNLYKSMASAVSIILVVVLSMLIFPDIFIGMYFVLGTICVVLAVLLYNSVNE
What are the official names of this protein?
UDP-galactose translocator 1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cytoplasmic granule membrane. Note=Localizes to cortical granules during meiotic prometaphase I and metaphase I.
Protein: NADK_PSEA7
Sequence: MEPFRNIGIIGRLGSTQVLDTIRRLKKFLIDRHLHVILEDTIAEVLPGHGLQTCSRKIMGEICDLVVVVGGDGSMLGAARALARHKVPVLGINRGSLGFLTDIRPDELEAKVGEVLDGQYIVESRFLLDAQVRRGIDSMGQGDALNDVVLHPGKSTRMIEFELYIDGQFVCSQKADGLIVATPTGSTAYALSAGGPIMHPKLDAIVIVPMYPHMLSSRPIVVDGNSELKIVVSPNMQIYPQVSCDGQNHFTCAPGDTVTISKKPQKLRLIHPIDHNYYEICRTKLGWGSRLGGGD
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMNL2_BOMVA
Sequence: MNFKYIVAVSILIASAYARREENNIQSLSQRDVLEEESLREIRGIGASILSAGKSALKGFAKGLAEHFANGKRTAEDHEMMKRLEAAVRDLDSLEHPEEASEKETRGFNQEEKEKRIIGPVLGLVGSALGGLLKKIG
What is the function of this protein?
Bombinin H2 has antibacterial and hemolytic activity.
What are the official names of this protein?
Bombinin-like peptides 2.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYN_STRSY
Sequence: MSRKLITINQVKDYVGQEVTIGAWVANKSGKGKLAFLQLRDGTAFFQAVAFKPNFIEKFGEEAGTEKFDVAKRLSQETSVYVTGIVKEDERSKFGYELDVTDLEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAIQQIRNAIIYATYEFFEKNGFIKFDSPILSGNAAEDSTELFETDYFGQLAYLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFLSHEESLDLQEAYVKALIQGVIDRAPQALETLERDVDALKRYIAEPFKRVAYDDAITLLQEHEADKDTDYEHIEHGDDFGSPHETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREDNYDALVAKMDELGMDKSEYEFYLDLRKYGSVPHGGFGIGIERMVTFVAGTKHIREAIPFPTFVAPLASVIQSSIFPFITSTYEETPFPFSQVQIFSSLLDLVWPSLITVGTSWPITKIKRKNCKIIFP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U2AFB_ORYSJ
Sequence: MAEHLASIFGTEKDRVNCPFYFKIGACRHGDRCSRLHNRPTVSPTIVLANMYQRPDMITPGVDAQGQPIDPEKMQEHFEDFYEDIYEELSKFGEVETLNVCDNLADHMIGNVYVQFREEEQAVAAHNALQGRFYSGRPIIVEYSPVTDFREATCRQFEENSCNRGGYCNFMHVKQIGRELRRKLYGGRSRRSHGRSRSPSPRHRRGNRDRDDFRRERDGYRGGGDGYRGGGGGGGGDGYRGGDSYRGGGGGGRRGGGSRYDRYDDGGRRRHGSPPRRARSPVRESSEERRAKIEQWNREREEKP
What is the function of this protein?
Necessary for the splicing of pre-mRNA.
What are the official names of this protein?
Splicing factor U2af small subunit B, U2 auxiliary factor 35 kDa subunit B, U2 small nuclear ribonucleoprotein auxiliary factor small subunit B, U2 snRNP auxiliary factor small subunit B, Zinc finger CCCH domain-containing protein 38, OsC3H38.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMM_PSET1
Sequence: MSQENTSSIIVVGKLGAPYGIKGWLKVHSFTDDPAGIFDFSPWLIGQQGKWQTLEVVDWRRHNKGFIAKFAQVNDRDEAVAYTHAEISMDSAQLPELPQGEFYWRDLIGMSVVTDKGYDLGIVDDLMETGSNDVLVVKANSKDAFGQAERLIPFLTDTVIIEVKHDAREITVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL40_METS3
Sequence: MARFEEAENRMFNVKICLKCNARNPAAATTCRKCGYTGLRFKAKEPRG
What are the official names of this protein?
50S ribosomal protein L40e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL40 family.
Protein: RL9_CAMC5
Sequence: MKVLLIKDVKSLGKAGEIKEVKDGYGNNFLIGKGLAKAATPDVIRQYEAAQKRKEEELKYEISNLEKLKDELSKITLVIKKTLGANGSLFGSVSKEEIAEELEKAHHLIVDKKAIEIDKNHLKAVGLYDVQVKLGHAISATLKVDVQGE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: CLPS_LEPBP
Sequence: MSESNRKSYTDFNVELLEKEKQKKKLKKPDRYKVILINDDYTPQEFVVYVLAVVFRKSMDESRQIMWRAHTEGSAVCGVYSLDIARTKVAEVHKLADDAGHPLQCQLAKEEEE
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: RUVB_ACIC1
Sequence: MTDEPLTDRPPAVDLGRLLIDAHAESDEHAVEAALRPRRLDEFVGQQRVRDQLSLILDGAKQRGRPPDHILLSGPPGLGKTTLAMIVAAELNTPIRVTSGPAIQHAGDLAAVLTQLSEGEVLFLDEIHRMARPAEEMLYLAMEDFRVDVVVGKGPGASVIPLELAPFTLIGATTRTGLLPGPLRDRFGFTARLDFYEPADLERIVHRSARLLDVRITPDGAAEIARRSRGTPRIANRLLRRVRDYAEVRADGVITCEVAQAALAVYEVDEHGLDRLDRAVLDALVRRFGGGPVGLGTVAVAVGEEPETVEEVAEPFLFRAGFLIRTPRGRMATAAAWRHLGITPPPEALGAAQLAFEIDRDAGEPTA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: HNF1A_CHICK
Sequence: MVSKLSHLQVELLGALLESGLTKETLIKGLSEAEPYVLQSESQHAINALQTEKGESCPEIPNLPNGMGETRLSEDETSDDGEEFTPPIMKELENLSPEEAAHQKAVVERLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGILTEEPMGDDLPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEEREALVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDNFSGPQPTSAPPLTPHNSSSLQPPPALSPTKVHGVRYNQQPASEAESSSSNHHGNSSMVTTQTILHQVSPPGLEPSQNLLSTDTKLISAPGGTLPPVSTLTALHSLEQNPHALGQQTQNLIMASLPGVMAIGAGETSSLAPRFTNTGGSTLVIGLTSTQPQSVPVINSMGSSLTTLQPVQFSQQLHPSYQQPLMQQVQSHINQSPFMATMAQIQNPHALYGPKSEVAQYTHTGLLPQTMVITDTANLSALTNLTPTKQAFTSDSETHTDSGIHTPVSQAPAIHLQNQDTAIQHLQSGPRLTPSPAVSSSSLVLYQSSDSTNSHSQLLPSTHNVIETFISTQMASSTQ
What is the function of this protein?
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver.  May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver.  In liver it could repress the gene while in oviduct it may act as an activator.
What are the official names of this protein?
Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, Transcription factor 1, TCF-1.
What is the protein family that this protein belongs to?
Belongs to the HNF1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPE_BURMS
Sequence: MATIKVDVVSAEEQIFSGQAKFVALPGEAGELGILPGHTPLITRIRPGAVRIESESGDEEFVFVAGGILEVQPGAVTVLADTAIRGKDLDAAKAEEARKRAEETLQNAKSDIDLAKAQSELATAMAQLEAIQRLAKIRGKH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL6_PSET1
Sequence: MSRIAKAPISVPAGVEVTLKGQEITVKGKNGELTRTINNAVEVKVEENVITTLPREGVTDAWAQAGTARALINNMIVGTHEGYEKKLQLVGVGYRAAAKGKTLDLTLGFSHPVHFAVPEGITIETPSQTEVLVKGVDKQLVGQTAANIRAYRKPEPYKGKGVRYSDENVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.