Protein: NSY1_CAEEL
Sequence: MSQNNKRQVQHNHEMSNDVCPLPLPPRGAPPPTAYHASRMAATSSSTNGSFEKSAIPGNARKLHVVIVIDQKVQKNLRVREMALKDVQKVADTLNVNLTRIDFDKLDFGETETLDLFYNADVALVDVTVTHQQPSLCYHIGVRESMGQSYNMILTYWSPDPEYHIMDALKKTHAHLPMIVYIHHQDSNQLQSYDKNNNDDDSKPPFARTNVPAKTITFQHRMKQVLKSVQVEASAHSREKFMSDLRKAREITDGDQKNDYLDKMRTRLDNPDVLHPDTVSLMMLSYRDNQNYGGMIRLVDDLKRIPDCLKVVDTPVIRYQYAFALNRRNKDGDRDLALNTVLSLVEGTTENEEKNGPLSPDVVCLAGRIYKDKFIASNYEDRESLNSAIEWYRRAFEMSPLEYSGINLTTLLRASGEHFENNLEMQQIAVVLNSLLGRKGALQNLMEYWDVATYFEVSVLAENYQKACEAALMMVKLKPPVWYLKSTMENIKLINRCAATISPIEKEKQQFLFWSEFFMEATEADTDISCPRYPVLILELNKEFTPSYLTLNNEEGTVILSHVLENSQQKKIHQSELRGIHRWHFARNNIKAVTESKRDDRQLFLYVHENSDDFNLLFPTKAHCKKAYDDMKSMADVADGNYQGRVLSNPDNEKIRFEYELSNSNERVVLGKGTYGTVYAARDMDTQRQIVVKEIEVKYDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCKRLAGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIYHNHHSISRTRSGSINKKPATKIELNHDKEKKEKSKNQREMLRSTSHIGGMGVVERSPPTPEPMSATLTAGFSHVHSQTVSNALSTAREEKKLHLKIDHARNRTFSSSSPVPDGQSSAGTNMSHPGFQLSQPSSPIVDDTNHPHLIVSPISLNTMGSPLSSAALLNRTISDESSNSSSRFFMLQKDSERRRSLGQFMQDYKDLIIDSWSTLLIKQSDTELVVTVYMLEMLLDGMRDFLLKKDNTKMQKMIDDIRGLLDYDTAKIGQINLALYHFSDSIQPVLRRLDIKPHWMFALSNLITSAVQCAISILSPDLSLLLHAQDNLPSTSSIVAIRNSSLSEGEALIESRPPSREERVREDRKELRTLQEENEILIERLLQVERELNAQLKSGITRANRFRDFAMYRNTYPPFRTPPVAHAPPTPPFSASCGAQPSGTFTNQPPSFASIKPIAQKIIMPPGTENNYQVTRVQEELVSWLRGLEIDERSIALIASEAYTKSDMMDFVTRDELLSIGVGGGSSCRIMRAIGEVRERQRRQPVFLSPMRSRDDSLDDYHSSSADDMYTGAAAETSSGN
What is the function of this protein?
Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1 (PubMed:11751572, PubMed:12142542, PubMed:21212236, PubMed:24448648).  Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development.  Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons (PubMed:11336672, PubMed:11751572, PubMed:15625192).  Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection (PubMed:12142542, PubMed:18394898, PubMed:24448648).  Involved in resistance to the nematotoxic C. cinerea galectin Cgl2 (PubMed:20062796).  Probably by activating the sek1/pmk-1/skn-1 pathway, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection (PubMed:22216003).  Probably downstream of tir-1 and nipi-3, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:18394898).  Plays a role in resistance to several environmental stresses including oxidative, protein misfolding (ER) and osmotic stresses, and DNA-damaging reagents (PubMed:21212236, PubMed:15888317).  Plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress (PubMed:22308034).  Involved in germline apoptosis induced by heavy metals, such as Cu(2+) (PubMed:19497412).  In addition, plays a role in the up-regulation of gcs-1 upon arsenite treatment, most likely through activation of pmk-1, to confer protection against toxicity induced by heavy metals (PubMed:25204677).  Plays a role downstream of tir-1 in regulating susceptibility to anoxia (PubMed:21212236).  Involved in egg laying (PubMed:12142542).
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase nsy-1, Apoptosis signal-regulating kinase 1, ASK-1, Neuronal symmetry kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
What are the subcellular locations of this protein?
Cell projection, axon. Perikaryon. Note=Localizes to post-synaptic regions and is enriched in punctate structures in AWC neuron axon where co- localizes with tir-1. Localization is regulated by tir-1.