Protein: APMA_PENBR
Sequence: MPSIVIDDADRLRQLWTQLVTDVTPSHLPSGLFSKRETKSTVGRLNVPMQLSAIYDCCQQCDVSPLNVVQAAWTAVLRSYSGADNVMFAGIGMNPRSTKQQWTNTSVSLARLEQDSSVISVLDTTQEEGLLQAESMVSVPEALDIFSSLEPKPCNSAIWLKDAQSKSELSLTDVVNEKTFDYAVQIDASLTQLDLVFHKPTVSRSQAQYIASTFADYLQSVCLDPYQTASTVCHPSELDMMQIDTWNRILPKGSEVCVDQLIESAAQKSPDAQALVGWDGEMSYSQFNQAANKMAAYFDSVGVQRGELVPICFEKSVWTIVTMIGLWKLGAGWVPLDPKHPRQRLETIIESVGARTVIASASNKDLVQDIASQVLILDPSQIQSAPEVDFKSRSQPHDTSFVMFTSGSTGKPKGVVHDHASVASSALNHASAMNISNNTRALQFGAYTFIISTFEIFTTLIFGGCLCIPSDHDRHTDIRPAIRSFEANWAIFTPSFARSLHHEDIPSLDTLLVAGEAVAQDIIDRWAPVAQLINIYGASECSVVMIGRMVADTPRSCIGRATGGLSWLVDPNDHDRLVPIGSVGELVIEGPILARGYLADPEKTQAVYIENPVWASQSGNTRRFYKTGDLARYGDDGRVHLIGRKDLQVKIRGQRVELTEIEAHMRAIDNSVKTAVAMVRPGGKAMLAAFISNQSGFGPEFPHPFYSAPDDKQSVVSLAGQMSKKLTLQLPPYMIPSVFLPLAYMPLTASGKTDRRLIASFGDSLTLTELAAVAGNGKVTERRMPTTTTEMTLRQIWAEILHCPVDEIGAEDNFFHLGGDSIEAMNLTRRCRAEGFQLQVGDILGNLVLSDMAKAMTSTRSLKPSITTPFELLGDDTDAVRANILSATGLPAGLLQDAYPCSPLQMGLMALSAKIPGSYVARHTLELPSSVTVGRFKEVWGMIVESNDVLRTRIVETDEYGSVQVVNRAPLVWAHDTDLAKYIELDEKIPMQIGDALAHFGIIAGPTNTFVLTIHHSIYDGMSLEMIFNDLVHAFEGVVPPVRTQFRDFIKEVVERNADKATEEYWRGEFAEGDMTTFPSLPSASHQPLANDSFVHTLQLNRKGPSDFTSATLIRAAWSLVQARYCDSPETVFGCTLSGRNAPVPGVEDVVGAVIATVPIKAKVDGEQPVAEWLQQINSHSVEMTPAQNYGLQNIARVAEGAAAACNFQSLLVIQPATSVAEDSIMQPFSAPQANFSTVALTLECSLAVDGSIQIHVHFDDTVLPRLEVQRIVRQFEHVLQQLASAPAGKLSDIEIISPQDKENLLQWNRDLAEPVNECVHRLISQNNFSQPNAPAICAWDGELTYTELESLSSKLAAHLINVGVGPDVFVPLCFEKSMWTIVAMLATLKAGGAFVAMDASQPISRMQSVVKDVNAQVVLYSEEQLSRAPGLAAKAIAVGPGMRELNTPRTPPTPVAPSNAAYVIFSSGSTGTPKGSVIEHRAFCTAAVSQKEGLQMGSRVLQFASYAFDASILEILSTLVQGGCVCVPSESERRGNIAEAITRMNVDWAVLTPSFVNTIDPSSVPTLSTLALAGEAMSAAHVAAWTPYVRLVNGYGPSECCVCTTSNRRVLPGTASNNIGTAVGSASWITDRDDHNKLAPIGAIGELLIEGNILARHYLNNPEKTDAAFITQPAWLPGHRSTRVYKTGDLVKYAPDGSILFIGRKDTQVKIRGQRVELGEIEYHLNLPADVSQSVVSYPKSGLYAQKLVGILELNSTAGSDLSVVPSAEFQRSGFQLSSLTHTLSETLPVHMIPVIWIVVRKIPSSSSTKIDRKVVDQWLTKLPSNFEPTLGITREGPTTSALRASEDKALAISKKIESLVNREDSPLHGRDFNISSMGIDSVQVISLASFIKQSYGVKVDVSRVLDGQMTVRGLAAFIDAELSGTVQEALPAFDAMKEASALVNDIIKNSMPQKTVFVTGGTGFLGTQILRQLCDRPDVGRVIAHVRANSPSDAFIRIKDAAVRAQWWSDYYLTKLDVWCGNLASPKLGLKPKQWASLSGESPNDGLVNGIIHAGAAVNWNAGTEILRAANVNSTAELIKAAISSPARPRLSYVSGGSRWSVGENDQDIANEIAHANGYAQTKYLSELLVKQFAAKYPNQFAIVKPGLILGTPEEGVANTDDFVWRLASGVVDACAFSDDYANAWMYVTSSTRVAEETIAQVFCPAGSMKTVTYMTEGITEREFWEIFHGELKYPLRKVDHETWMETMRKSIQKDTSSHPLWPVSQVFDALQGRLGGEPLQDASFVSPSQKQHVKATIRRNVQFLVEAGFIASPTGKKMKYMADKVFKRSGNVWENVKRMTITA
What is the function of this protein?
Nonribosomal peptide synthase; part of the gene cluster that mediates the biosynthesis of asperphenamate, a rare linear amino acid ester that exhibits antitumor activity towards a number of cell lines (PubMed:29719714).  The structure of asperphenamate contains two subunits, N-benzoylphenylalanine and N-benzoylphenylalaninol, which are connected by an inter-molecular ester bond (PubMed:29719714).  The first step of asperphenamate biosynthesis is the generation of N-benzoylphenylalaninol by the nonribosomal peptide synthase apmA (PubMed:29719714).  Using phenylalanine and benzoic acid as substrates, apmA catalyzes amide bond formation and tethers the intermediate into the NRPS chain.  Then, the terminal R domain of apmA catalyzes the reduction reaction to get the shunt product N-benzoylphenylalaninol (PubMed:29719714).  Subsequently, the nonribosomal peptide synthase apmB activates the same substrates as does apmA (phenylalanine and benzoic acid) to produce N-benzoylphenylalanine before condensing N-benzoylphenylalanine and N-benzoylphenylalaninol to release asperphenamate (PubMed:29719714).
What are the official names of this protein?
N-benzoylphenylalaninol synthetase apmA, Asperphenamate biosynthesis cluster protein A, Nonribosomal peptide synthase apmA.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.