PharMolix/UniProtQA huggingface dataset:
Protein: YCF4_PORPU
Sequence: MKQVLPIHKVRKDVILGSRRFSNYWWASTIFIGALGFLLAGLSSYFQTDLLPFANSTELVFIPQGIVMTFYGSVGIFLSMFLWLTIIWNIGAGYNEFNKNEGIVKIFRLGFPGKNRQICLKFNIKEIKSIKIDIKEGLNPRREIYLCTKDKRNIPLTRVGQPLLLSEVEEQAAEIARFLDVVLEGA
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: OTC_METFK
Sequence: MALKHFLQFNDLNADELAHIFERTRWIKEQFKAYQQYWPLTDRTLVMIFEKASTRTRLSFEAGMQQLGGSAIYLNTRDSQLGRGEPVEDAAQVISRMSDIVMIRTFEQEIIERFAANSRVPVINGLTNEYHPCQILADIFTYIEHRGSIKGKTVAWIGDSNNVCNTWLQAAEVLDFNVHVSTPPGYEVEPERANLYGTDHYEEFTDPMEAARGADLVTTDVWTSMGFEAENEERRRDFHDWQVDADMMRVAGKDALFMHCLPAHRGEEVTADVIDGAQSVVWDEAENRLHVQKALMEYLLLGKVQV
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_SALAR
Sequence: MAKTLYEKLFDAHVVFEAPNETPLLYIDRHLVHEVTSPQAFDGLRAHHRPVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCNEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGNAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGDAIRALSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGSDFDDAVEYWKTLKTDDGATFDTVVTLRAEEIAPQVTWGTNPGQVISVTDIIPDPASFSDPVERASAEKALAYMGLQPGVPLTDVAIDKVFIGSCTNSRIEDLRAAAEVAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGRFADIRSIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RL14_CYTH3
Sequence: MIQQESRLSVADNSGAKEVLVIRVLGGTGKRYASIGDKVVVTVKSAISSSNMKKGTVSKAVVVRTKKEVKRADGSYIRFSDNAAVLLNNNDEPRGTRIFGPVARELRDKQFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: COAA_BRUSU
Sequence: MWEKVDQLTPSRYSPYRFFSAQEWAAFRADTPLTLTYEEVKRLRSLGDPIDLDEVRRIYLSLSRLLYAHVEASQLLFRQRQQFLNMEESYKTPFIIGVAGSVAVGKSTMARILKELLARWPSSPKVDLVTTDGFLYPNAVLREQNMMERKGFPESYDIGAVLRFLSAIKAGMSRVRAPLYSHLSYDVLPGEYQIVDKPDILIFEGINVLQVRDLPEDGKMVPFVSDFFDFSIYIDADPRLIHKWYIDRFMRLRETAFRDPQSFFHRYSQLSQEAARSIAEGLWQNINLKNLNENILPTRPRADLILRKGSDHLIEEVALRKI
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_HAEIE
Sequence: MFEYPQGYKLIAGVDEVGRGPLVGAVVTAAVILDPHNPIEGLADSKKLSEKKRLALADEIKEKALAWALGRAEADEIDEINILQASLLAMTRAVKSLKIQPHFVLVDGNKIPKDLDIPAQAVVKGDSIVAEISAASILAKVARDQEMEELDKQYPEYAFAKHKGYPTKLHLEKLAELGALPQHRRSFAPVKKALEQF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H1L_SPISO
Sequence: KGSSGMMSMVAAAIAANRTKKGASAQAIRKYVAAHSSLKGAVLNFRLRRALAAGLKSGALAHPKGSAGWVLVPKK
What is the function of this protein?
Linker histones are implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.
What are the official names of this protein?
Sperm-specific protein PL-I, PL-I, Sperm-specific linker histone H1-like protein.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PHO81_YEAST
Sequence: MKFGKYLEARQLELAEYNSHFIDYKALKKLIKQLAIPTLKASSDLDLHLTLDDIDEKIIHQRLQENKAAFFFKLERELEKVNGYYLARESDLRIKFNILHSKYKDYKINGKLNSNQATSFKNLYAAFKKFQKDLRNLEQYVELNKTGFSKALKKWDKRSQSHDKDFYLATVVSIQPIFTRDGPLKLNDETLHILLELNDIDNNNRRADIQSSTFTNDDDDDNNTSNNNKHNNNNNNNNNNNNNNNNNNILHNNYELTTSKISENQLEHLFQASSSSLDMEMEIENWYKEILNIATVKDVQRKHALLRNFRETKIFTYLLQNSSESFHKNVFSLLKECLTTLFLLLVASPLDDNSLHIFYKSNQDHIDLSYCDEDDQVFSRKNVFHEAASCPEKSRLFILDEALTTSKLSKETVQKLLNAQDIHSRVPLHYAAELGKLEFVHSLLITNLLEDVDPIDSDSKTPLVLAITNNHIDVVRDLLTIGGANASPIEKPILDYSKNVISSTKVQFDPLNVACKFNNHDAAKLLLEIRSKQNADNAKNKSSQHLCQPLFKKNSTGLCTLHIVAKIGGDPQLIQLLIRYGADPNEIDGFNKWTPIFYAVRSGHSEVITELLKHNARLDIEDDNGHSPLFYALWESHVDVLNALLQRPLNLPSAPLNEINSQSSTQRLNTIDLTPNDDKFDLDIQDSIPDFALPPPIIPLRKYGHNFLEKKIFIKLKLRPGLESIKLTQDNGIIMSSSPGRITLSSNLPEIIPRNVILPVRSGEINNFCKDISETNDEEDDDEISEDHDDGEIIFQVDSIDDFSMDFEIFPSFGTRIIAKTTAMPFLFKKVAINSIATMNLPLFDTRLNNIGSLTLDYQIIFPYPGNPLKIINYEPYWKSTGSDLMTSSKDGNFVTSSSLNGSFISVLVCALNDETIVAAPKPYVEFKGTKILLNDLTKEQLEKVVDYDFGKIDGSFDEVTLKQYLSSRVVPLRSLLEVIPGSAQLVIRVYFPTDKEIDTIPIKISPFININQFIDKLLLIIFEHERFLRHSGSGSMRQIVFSSCNWEACSILNWKQPNFPVLLQMKNLLRDSTTGKFVGDTPNCLKELAVNPQKMSYLNTELINIHTMVQFAMNNNLLGVTLPYEVLKICPSLARIIKQNGLLLIASVGENDQIPADGGYSGIYYACELLFENNIDM
What is the function of this protein?
Inhibits the kinase activity of the cyclin-CDKs PHO80-PHO85 and PCL7-PHO85 under low-phosphate conditions.
What are the official names of this protein?
Phosphate system positive regulatory protein PHO81, CDK inhibitor PHO81.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes predominantly to the nucleus in both high- and low-phosphate conditions.
Protein: ERG2_ASPFU
Sequence: MPSKSSSPQSNSTRKNSCGCCCFSVRKFGFLAVFVAIFAALYSYLDARLEQFYIFNPEHLHDLSQRAIQAHGNDTRAMVDFIVAELDQKIPGNHLNKNEEWIFNNAGGAMGAMYIIHASITEYLIIFGTAIGTEGHTGRHTADDYFNILQGTQVAFVPGTFEPEVYPPGTVHHLRRGEVKQYKMEQSCFALEYARGWIPPMLFFGYADTFTSTLDFPTLWATTRVTGREMITNLLRRKF
What is the function of this protein?
C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:16110826) (Probable).  Erg2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (By similarity).  The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane.  Firstly, the squalene synthase erg9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids.  Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis.  Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase erg1 and the lanosterol synthase erg7.  Then, the delta(24)-sterol C-methyltransferase erg6 methylates lanosterol at C-24 to produce eburicol.  Eburicol is the substrate of the sterol 14-alpha demethylase encoded by cyp51A and cyp51B, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol.  The C-14 reductase erg24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol.  A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases erg25A or erg25B, the sterol-4-alpha-carboxylate 3-dehydrogenase erg26 and the 3-keto-steroid reductase erg27, leads to the production of fecosterol via 4-methylfecosterol.  The C-8 sterol isomerase erg2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol.  The sterol-C5-desaturase erg3B then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol.  The 2 other sterol-C5-desaturases, erg3A and erg3C, seem to be less important in ergosterol biosynthesis.  The C-22 sterol desaturase erg5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain.  Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductases erg4A and erg4B to produce ergosterol.  Possible alternative sterol biosynthetic pathways might exist from fecosterol to ergosterol, depending on the activities of the erg3 isoforms (PubMed:16110826, PubMed:18191972) (Probable).
What are the official names of this protein?
C-8 sterol isomerase erg2, Delta-8--delta-7 sterol isomerase erg2, Ergosterol biosynthesis protein 2.
What is the protein family that this protein belongs to?
Belongs to the ERG2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: BIPC_BURP0
Sequence: MSIGVQSSGINISHAGLSRLVDAGKSEQGDKAVRDDGRALARADAALAAVVGERVAARRDAVAGSGAQRVELARPKPDAQTRATDRRTVSGLEREHKRLAASQTPRVTGMHDALVQRHVSLDGAKAAHGEGVKRAAGDAPRAAADAPQRFAFADDKAFDAMLALGAAMQKNVQSDLAMQGKLTMLAHDAMMSAAAQDRSIGAAQMTAAIAGGALQATTSLGGAMQQMKSLSTKSMSIEKELKPQAELKQFHAEQALELRGINKPVLSNDEVSHVKIKRDTGETVRHEIDHGGERMSDEHASVLAQEAPARQHRIDMHGMRHEENLVKAGRQQMKGDLLQSGGQIGKNQIDGASAQQQGADRAEQKEDENAQQTAMAAASTRDEAAHRSREAAQKAIDAAKSQVANDNAVAAQVAGNLRT
What are the official names of this protein?
Effector protein BipC.
What is the protein family that this protein belongs to?
Belongs to the invasin protein C family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the bsa type III secretion system.
Protein: PLSX_AZOSB
Sequence: MSVTVAVDCMGGDHGPVVTVPAVFAFLRSHADARAIAVGREEVLAPLIAPVAKEFGERLRLQPATEVVGMDEAPATAMRNKKDSSMRVAIDLVKSGEATAAVSAGNTGALMAISRFVLKTLPGIDRPAIATVLPSRDGRTYVLDLGANVDCSPEHLLQFGIMGAMLVSAVEHIDRPTVGLLNIGEEAIKGNEVVKQAGELLRTSGLNFKGNVEGDQIYTGGVDVVVCDGFVGNVALKTSEGLAQMLATFLREEFSRNLLTKLMAIVALPALGRFKRRVDHRRYNGASLLGLRGVVVKSHGSADAFAFEQALGRAADAAANRLIERIEERMSAMSQEAA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: AFP_DIOTE
Sequence: ATFDIQNKXTYTVWAAAWAPSYPGGXKQLD
What is the function of this protein?
Has antifungal activity against P. infestans.
What are the official names of this protein?
Antifungal protein.
Protein: DEOB_ECO5E
Sequence: MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_OLEA2
Sequence: MNIIKKIELEQMRLDIPKFKSGDSVKVHMRIVEGEKERIQVFHGNVIRISRGTTNATFTVRKISNGVGVERVFPMHSPFIDRIEVVQQGRVRRSRLYYLRNLKGKAARIKPLKTW
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: GREB_VIBPA
Sequence: MKTKLITREGYNKLKQEHDYLWNEKRPEITKIVTWAASLGDRSENADYTFNKRLLRQIDRRVRFLRKFLPEVTIVDYSPQQEGKVFFGAWVEIENEAGDVKKFRIVGPEEIYGDAKDYISIDSPMARAMLKKQVDEEFTVRTPEGDKEWFINSIEYNKQSAES
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreB releases sequences of up to 9 nucleotides in length.
What are the official names of this protein?
Transcription elongation factor GreB, Transcript cleavage factor GreB.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family. GreB subfamily.
Protein: HIS8_ALKOO
Sequence: MTTNLFRKELEVLKPYVPGKPIEEVQKEYGIDQIEKLASNENPLGPSPKAVEAIMREVQHINIYPDAYAMKLKEEIAKRTNLTHENIITGNGGEQIIQLIAQTFINPGDEAIMADTTFGLYETSVLNMKGVPVILPLKDYKHDLDGFVEKINENTKIIYICNPNNPVGNILSKEEMEGFVARVPENVVIVLDEAYYDYAKVNPEYPESLDVLAKRPNTVILRTFSKVGGIAGVRVGYALTSKEIASQMSKVKDVFNVNILAQAAALGVLEDTEHIEKTVKLNYESLGMMEKYCEENDLEYIKSNANFMFMNIGTHSKPVFEELMKQGIIIRPGFLWKWDNWIRVSTGTLEQTEKFIDKLDGILNKGTCCCG
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: YIDZ_ECODH
Sequence: MKKSITTLDLNLLLCLQLLMQERSVTKAAKRINVTPSAVSKSLAKLRAWFDDPLFVNSPLGLSPTPLMVSMEQNLAEWMQMSNLLLDKPHHQTPRGLKFELAAESPLMMIMLNALSKQIYQRYPQATIKLRNWDYDSLDAITRGEVDIGFSGRESHPRSRELLSSLPLAIDYEVLFSDVPCVWLRKDHPALHQTWNLDTFLRYPHISICWEQSDTWALDNVLQELGRERTIAMSLPEFEQSLFMAAQPDNLLLATAPRYCQYYNQLHQLPLVALPLPFDESQQKKLEVPFTLLWHKRNSHNPKIVWLRETIKNLYASMA
What is the function of this protein?
Involved in anaerobic NO protection.
What are the official names of this protein?
HTH-type transcriptional regulator YidZ.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: DRC1_HUMAN
Sequence: MNPPGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKINSELQVPPTQVLRVPTK
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity).  Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes.  Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437).
What are the official names of this protein?
Dynein regulatory complex protein 1, Coiled-coil domain-containing protein 164.
What is the protein family that this protein belongs to?
Belongs to the DRC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: QUEC_AQUAE
Sequence: MKKHDGIIVLLSGGMDSATLLWLAKREFKKVYAISFDYGQRHKVELKYAKELAKLAEVEDHFIVQVPFYTSLKGSALIDESVEVPKGEYPENEPPVTTVPMRNLIFLSIASAFADNLEVNYIGIGVHALDTPYPDCRPEFITAAEAAINAGSTFVAKKKERMHVYAPFLGMSKRDIALLGKELGVPFEKTYSCYMGTEPPCGECPTCIQREEALRGIL
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: MNMC_COLP3
Sequence: MKKLDKTNNSNKLSYQKDGTPYCQRFDDIYFESESGYQQSDFVFIQKNKIGLRLQIAKQTFTVAETGFGTGLNFLLTLQAYQKAQQVSSFQLAPLHFISVEKYPLTKEQLVQSLSILPQLQSLALTFINSYPDCPVEEFGQEFKTTFFNGQVRLTLIFDDAAQGFSSLNCSKEGLVDAWYLDGFTPAKNPDMWSKDLFSQIGRLSKDQATLTTFTVAGFVKRQLRDIGFRLEKLLAKGKKKEMLSAVMQSNPITNKGYYLRPLITKPQHVSIIGGGIASACAAYALTKQGVKVTLYCKDTSLAQGGSSNAIGALYPLLHQQEDDISSFYQQAFWRAKALYTEIAEQGFSFAHQWCGLLEVSYKEALIKRQQAFESLNTWPNELIHGVNAKQASELANIDLPYGGLFMPNAGWMSPRDLVKQIFNAAKSTTRLKIMTDTHITKIQQVANPSSNENGTSWSLTSNQGEFNASVLVICGGADAIEIEQLKSLPLTATRGQVTSMKSNKKINKLSTVICHKGYLTPENNGIHCIGATFQKNDTNITTNKADDDYNLTMLTKCLPELSSTIDWQEQDISSSKARLRCMSQDHLPLVGAVPDIKEHVATYSHLAKDKNWKYSQAAPCIDNLYVLLGLGARGLCSAPLAADILTAELCNTPYPVDSQMLFNLSPNRFIIRDIIKRKIKS
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG8_PICPA
Sequence: MRSQFKDEHPFEKRKAEAMRIRYKFADRIPVICEKVEKSDIPEVDKRKYLVPCDLTVGQFVYVIRKRIKIPSEKAIFIFIDDILPPTAALMSKVYEEHKDEDGFLYVLYSGENTFGDIPGVEEIE
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier ATG8, Pexophagy zeocin-resistant mutant protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: CYSI_AFIC5
Sequence: MDLKVKVDRSRDVSQPLDKLGPDETLKANSDQLRGTIAQSLADPITLAVDPSDNKLMKFHGIYQQDDRDIRDERRRQKLEAAYSFMARVRLPGGVCSTSQWLKLDELGRAYAGNTLRLTTRQTFQLHRVLKHHLRPALQGLREVVLDTKAACGDDTRGVMATVNPLVSKVHADVYALAKQASEHALHRTGAYREIWYEEERDPSTVKSAPDGSEEPFYGRTYMPRKFKIGFAVPPSNDIDVYAQDLGFIAIVKRGKLAGFNVAIGGGLGRTDQAPKTYPRLASVIGYVGVDKLFQTIDAVMSVQRDYGDRVDRLHARFKYTIDDKGLDWIKAEIERRLGFELAPAALYTFTSNSDPLGWVKGEDGHWHCTLFIQNGRVINHPGQPLMDGLREIARVHKGHFRITPNQNLIIADIAPEDRPAIEEVMKEYGLDAFETRSQLRLNSMACVALPTCGLAMAESERYLPDLISKIEPLLERYGLTDEPITIRMTGCPNGCARPYVAEIALTGRAPGKYNLYLGGGFHGERLNKMYLENVGESAILDALDKVLGHFARERTPGEHFGDFAIRAGYVAEVKEGRYFND
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: AMIE_PSEFS
Sequence: MRHGDISSSPDTVGVAVVNYKMPRLHSKAEVIDNASKIAEIIVGMKQGLPGMDLVVFPEYSTMGIMYDHDEMMATAASIPGEETAIFSAACRQANTWGVFSLTGERHEAHPHKAPYNTLVLINNLGEIVQRYRKCIPWCPIEGWYPGDRTYVCDGPKGMKISLIICDDGNYPEIWRDCAMKGAELIVRCQGYMYPAKEQQVQMSKSMAWANNCYVAVANAAGFDGVYSYFGHSAIIGFDGRTLGECGEEEMGIQYAQLSVSQIRDARANDQSQNHLFKLLHRGYTGMHASGDGDKGVADCPFEFYRTWVLDAQKAQENVEKITRSTVGVAECPVGNLPHGGKEQTAG
What is the function of this protein?
Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.
What are the official names of this protein?
Aliphatic amidase, Acylamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: HMN10_HUMAN
Sequence: MTTRGFSCLLLLIREIDLSAKRRI
What is the function of this protein?
Plays a role as a neuroprotective and antiapoptotic factor.
What are the official names of this protein?
Humanin-like 10, HN10, MT-RNR2-like protein 10.
What is the protein family that this protein belongs to?
Belongs to the humanin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm.
Protein: MED4_SCHPO
Sequence: MEYQRAIDSIEECLNKQLRLSSEKVDQYVLIENWTSLVGHLKTLHSLISNYTNGRELQNEISSLLKQDKELDLQIQDCMREMTSIYDTHLPKTVSGRKRQKVNAETLLDYGRKLSKFSSAPPGYNPETGQDAKAPVHYPWPSEDQMRKTLLFQFSTSMVPNLSATASQLFSEQPPKTNEPTETETEIDANKAVEEKTKMNYPASPTFTTQEENKEVESPANKDVFAGFDLFDPEMEEDF
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 4, Mediator complex subunit 4, RNA polymerase II mediator complex protein pmc4.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.