PharMolix/UniProtQA huggingface dataset:
Protein: SPAST_ANOGA
Sequence: MVRNKYTLTTAGKSPSKKSRTGSLSKQHDATGDDDGETGTLDGSGSAAGSPVGGGTDAAAKRCDGGSVHKQNLYIISFPVIFVFNVLRSLLYQLFIVFRYVYNFTTKVVYRPVRKECGLEIVINTDQHGHHHHHHHRHSSHSIHSTAAAHQLQQHQQQQQHQYSLLQQEQHGVTEPQQQQQQQHQAAHPLQCSQSGILVNGEGREMSIQRSASGSQVGPGDPLLAKQKHHHRRAFEYISKALKIDEDNEDQKELAIELYRKGILELERGIAVECWGGRGEVWERAQRLHDKMQTNLSMARDRLQFLGMLCVCVSVQRKHLHPTRTTLPYRDVKSKLHTTPTENRMVSFNENCTITTNHHPARGTAASSRPTTAATAPATPSLPIKQTASEASGRKLTVGYKRPGNLGVMNKSQTLPRSMGGTRTTPTGTGGAGGIAGGLGNGGTYGGSIVGGGAGMPKIVPKPAATPPAIRRQFSVSIPIPGSSPVRKASNGYGSKNTPPPRSKTPLAGQQPQQPQQQQQQQPQISVKGVEPKLVQIIMDEIVEGGAKVQWQDIAGQEVAKQALQEMVILPSVRPELFTGLRTPAKGLLLFGPPGNGKTLLARAVATECSATFFSISAATLTSKYVGDGEKLVRALFAVARELQPSIIFIDEVDSVLSERSSNEHEATRRLKTEFLVQFDGLPANSEADRIVVMAATNRPQELDEAALRRFPKRVYVTLPDRDTRELLLRRLLQKQGSPLSDADLAHLAQLTEGYSGSDLTALARDAALEPIRELNVEEVKNMDPTKLRSIRESDFHNSLKRIRRSVAPQSLAAYEKWLQDFGDVTL
What is the function of this protein?
ATP-dependent microtubule severing protein.  Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation.
What are the official names of this protein?
Spastin.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family. Spastin subfamily.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Note=Forms an intramembrane hairpin- like structure in the membrane.
Protein: AFT2_YEAST
Sequence: MKAKSMKSIISVPISVSKTGKMKLTASPDNLASMMSKDQNKLIHLDPVPSFEDRHEIKPWLQKIFYPQGIDIVIERSDSSKVTFKCRSVRSKVGLNPKSKGSSSRSHACPFRIRAAYSVRLQKWNVVVMNNIHSHELRFDLITKTDDYKKFKENLRQKNDEKAIKTFDELEYKASLNLPLVTPIISCDCGLTKEIEAFNNIFLPLSNPPLTSKKNLLKTNKNSVSKIKSRQMDNSKPRPRLKTKLDADLHDTGFLDNFKTRNSCVKIEKEDSLTNLNEIDFTNMFCNDNFIQNYNQGLMELLTEPTPGPSSSSCILPSTPTRPLSQSKMDIALSESTTSSPNFMETDAPYGDEIIKVSKDTKSNAPTADTDIATNLGKERNENFGMLNYNYEALLHFNDEHFNELNSIDPALISKY
What is the function of this protein?
Transcription factor required for iron homeostasis and resistance to oxidative stress.  With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon.
What are the official names of this protein?
Iron-regulated transcriptional activator AFT2, Activator of iron transcription protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: KCY_CLOB1
Sequence: MLDISIAIDGPAGAGKSTIAKIIGNKLNIMYINTGSMYRAVTLMALKNNIEPYDIESLKALINSMNISFNGNNIIVNGKDLEEDIRMPIINNNVSKYAAVEEVRELLVSMQQNISKKYNVVMDGRDIGTVVLKDAPYKFFITASAEVRAKRRLKELKEKGININFRDVLKEIKERDYIDSNRKVNPLKQSKDAILIDTSNFTIEEVVDKICTIIKKD
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_METM5
Sequence: MSQKWGLVHIYASYNNTILHVTDLTGAETIAKVSGGMIVRNQRDESSPYAAMQAAFKIADLMRDKGIDQVHVKVRATGGQKSKNPGPGAQAAIRALSRAGIRIGRIEDATPIPHDGTTPKRKNR
What is the function of this protein?
Located on the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: FLIG_BRADU
Sequence: MAGPKRAAILMLALGEQYGGKIWSMLDDDEVRQLSLEMSTLGTVEVDTVEDMLLEFVSRMSASGALMGNFDATERLLQQYLPPERVNGIMDEIRGPAGRNMWEKLSNVQEEVLANYLKNEYPQTIAVVLSKLKPEHAARVLGIFPEDLALDVVNRMLKMEAVQKEVIESVEKTLRTEFMSNLSQTRRRDAHEVMAEIFNNFDRQTETRFITSLEEDNRESAERIKALMFTFDDLVKLDSGSAQTLMRNVDKDKLGVALKSANEDVRNFFFGNMSSRAAKMLQDDMAAMGPVRLRDVDEAQALLVNLAKDLAAKGEIMLTKNRADDELVY
What is the function of this protein?
FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body.  This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
What are the official names of this protein?
Flagellar motor switch protein FliG.
What is the protein family that this protein belongs to?
Belongs to the FliG family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Protein: SARZ_STAAW
Sequence: MYVENSYLSKQLCFLFYVSSKEIIKKYTNYLKEYDLTYTGYIVLMAIENDEKLNIKKLGERVFLDSGTLTPLLKKLEKKDYVVRTREEKDERNLQISLTEQGKAIKSPLAEISVKVFNEFNISEREASDIINNLRNFVSKNFDYSDKK
What is the function of this protein?
Activates transcription of virulence factors alpha- and beta hemolysin genes (hla and hlb).  Also, activates RNAIII expression, a central regulator transcribed from the agr locus (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator SarZ, Staphylococcal accessory regulator Z.
What is the protein family that this protein belongs to?
Belongs to the SarZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPA_PASMU
Sequence: MTFAVGQRWMSESENNLGLGLIVAIDRRTVTILFPASEEQRIYALNSAPLTRVLFQIGDEIAHHEGWKGNVLDILENNGVAFYLLKRQDNGEEITIQERDIAHQMTFSKPQDRLFTTQIDRNEHFTLRYQALTHQQAQFQSPLRGLRGIRAGLIPHQLHIAREVGQRTAPRVLLADEVGLGKTIEAGMILQQQLFAEKVERVLIIVPETLQHQWLVEMLRRFNLHFALFDEERCADFEDPASALWINPFNTESQIICALDWLCEKPKRVEQLLEAGFDMLIVDEAHHLGWSEHNPSLEYQLVEQLARQIPAVLLLTATPEQLGQESHFARLSLLDPDRFYDYQAFVQEQQQYQPVAEAVQSLLADKPLSAVEKNHISDLLSEQDVEPLLKVLDSQAHDEQKALARQELIDNLIDRHGTSRVLFRNTRQGVKGFPHRTYNQITLELPKQYNNAANVLAMLGEKGDNDSFYPEQMFQKLNPDARWWEFDPRLEWLITFLKNHREEKVLVICRHANTAIQLEQALREKEAIRAAVFHEKLSIVERDRAAAYFAQQEDGAQLLLSSSIGSEGRNFQFASHLVLFNLPDDPDLLEQCIGRLDRIGQRRDIQIHVPCFADTAQVVLARWYHEGLNAFEETCPMGMTLFEAHQTQLNKFLQNPTALEGFAEFVSLTRKQQHELKQALEKGRDRLLELNSNGGEQAQQLATDIAEQDGTTELVNFTLNLFDIIGVDQEDLGEKSIVITLASNMLVPDFPGLKEEGATVTFDRQLSLAREDVEFISWDHPLIRHGIDLITSGDIGKSAVSLLINKALPAGTLLLEMIYVVEAQAPKGLQLTRFLPPTPIRLLLDQKGNNLAEQVSFSALQKQLKPIGKNMANKVVKMVRPNIEQLVKLSEQKIVAQAQQIIHNAQQLADQTLSAELNRLTALQAVNKNIRQDEVDALDNIRSQSLAQLQQATWRLDSLRVIVSNKE
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: LDLR_HUMAN
Sequence: MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
What is the function of this protein?
(Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
What are the official names of this protein?
Low-density lipoprotein receptor, LDL receptor.
What is the protein family that this protein belongs to?
Belongs to the LDLR family.
Protein: SYV_PSEU2
Sequence: MDKTYQPHAIETSWYQTWESENYFAPQGVGDSYTIMIPPPNVTGSLHMGHGFNNAIMDALIRFRRMQGRNTLWQPGTDHAGIATQMLVERRLEAQGVSRHELGREKFLDKIWEWKAESGGNISRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKRLVNWDTKLHTAISDLEVENHDEKGHLWNLRYPLADGAKTAEGLDYLIVATTRPETMLGDAAVAVNPEDERYKALIGKFVELPLVGRRIPIIADDYCDPEFGTGCVKITPAHDFNDYEVGKRHNLPLLNIFDKNANVLPAAQVFNLDGTLNESVDGSLPAAYAGLDRFEARKQIVAAFDAAGLLVSVDDHALKVPKGDRSGTIIEPWLTDQWYVSTKPLAEPAIAAVEDGRIAFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDESGKVYVGRDEAEVRAKNNLGPEVALQQDNDVLDTWFSSGLWTFSTLGWPEKTKALKTFHSTDVLVTGFDIIFFWVARMIMLTMHLVKNEDGTPQVPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGIDLETLVEKRTSGLMQPQLAKKIEKQTRQEFADGIASYGTDALRFTFCSLASTGRDIKFDMGRVEGYRNFCNKIWNAARYVLDKGEDCGQNGEAVELSLADRWIISQLQRTEAEVTRQLDQFRFDLAAQALYEFIWNQYCDWYLELSKPVLWDETAPVERQRGTRRTLVRVLEVALRLAHPFMPFITEEIWQRLAPLAGAQGKTIMLQPWPVANEARIDQAAEDDIEWLKGLMLAVRNIRGEMNIGPGKPLQLFLKNVSAEDQRRLSENDYLLKKLAKLESMTVLTEGAEAPLSATALVGDMEVLVPMAGLIDKGAELARLDKEIQRLQGEVQRVGGKLSNAAFVDKAPPEVIAKERAKLTEAEQALGKLAEQHARIASL
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_RICCK
Sequence: MNQTIKVKKKKKTITLGVVHIRASFNNTIVTFTDIQGNTISSASAGSNGFKGARKATPYAAQVTIDRASEKAKEYGLKTISIRIGGPGAQRESAMRALFGQNFVVTSILDVSSIAHNGVRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: Y455_TROWT
Sequence: MTHDVSKYALGRIAEDKACDYLSVNGYIVLDRNWYCRFGELDIIARKNGVIVAVEVKGGKRNADYPICNITVKKLSKLTFLLKAWLHENKLNEFCIDLRIDAISVTFIPELQIRHFVGIL
What are the official names of this protein?
UPF0102 protein TWT_455.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: UVRC_STRSV
Sequence: MNKLIQSKLELLPTSPGCYIHKDKNDTIIYVGKAKNLRNRVRSYFRGSHDTKTEALVSEIEDFEFIVTESNIEALLLEINLIKENQPKYNIMLKDDKSYPFIKITNETYPRLIITRQVKKDVGLYFGPYPDVGAANEIKRLLDRLFPFRKCTNPPEKVCFYYHLGQCKAHTICKVDSQYFKELAQEVAAFLKGQDDQIIEDLRGKMAGAAQAMEFEKAAEYRDLIQSIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNLFPYYNDPDEDFLTYIGQFYQEKSHLKPNEILIPADIDEEAVRAMVDTKVLKPQRGEKKQLVNLAIKNARVSLQQKFDLLEKSIEKTQGAIENLGQLLNIPTPVRIESFDNSNIMGTSPVSAMVVFVNGKPSKKDYRKYKIKTVVGPDDYASMREVIKRRYSRVIRDGLTPPDLIVIDGGQGQVNIAKEVIQEQLGLDIPIAGLQKNDKHQTHELLFGDPLQVVELSRNSQEFFLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIEGLGPKRKQNLMKHFKSLTKIKEASVDQIVEVGVPRAVAEAVREKLNPKTQEQEQAQLREVAEPQIGLE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBIQ_RHOCB
Sequence: MSIASIDRVAAQGRWRNRPLAEKCLIGLGFLALAVTVPPFPGAVLVTVAILAFTFLGARVPLRFWAAVAVLPLGFLTTGAAVLLIQIGPDGIGLAPQGPAKAAALVMRASAATCCLLFLATTTPAADLLSGLRRWRVPAELIEIALLTYRFVFILAEEAAAMTTAQRARLGHATRRRWLRSTAQVIAALLPRALDRARRLETGLAARNWQGEMRVLSTRPAASPLVLGLILTLQAAILAAGVLL
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.  The complex confers cobalt uptake upon expression in E. coli; can also transport nickel with a very low affinity.
What are the official names of this protein?
Cobalt transport protein CbiQ, Energy-coupling factor transporter transmembrane protein CbiQ, ECF transporter T component CbiQ.
What is the protein family that this protein belongs to?
Belongs to the CbiQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EFP_MALP2
Sequence: MSQIIHAKDLRPGNTFIYKNNLYLVIENSFNKTAMREGIVKCKVKNLRTSSITVEVLTGEKLERAIIDKVKAMYSYADKNTLVFMDGESFEQIEIDANKLKWEKNFIVDGSEVSILKYGEEVLNVSLPDQVSLLVDFAEEAVQGNTVQTAMKKARLETGLEIEVPQFIKTGEKIIVNTVDGKYVGRDK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLASR_HUMAN
Sequence: MWHEARKHERKLRGMMVDYKKRAERRREYYEKIKKDPAQFLQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTPPLLTTISPEQESDERKCNYERYRGLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDEKKKLAEKKASIGYTYEDSTVAKVEKAAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVRMLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPHYRH
What is the function of this protein?
Probably functions as an alternative splicing regulator.  May regulate the mRNA splicing of genes such as CLK1.  May act by regulating members of the CLK kinase family (By similarity).
What are the official names of this protein?
CLK4-associating serine/arginine rich protein, Splicing factor, arginine/serine-rich 16, Suppressor of white-apricot homolog 2.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SENP6_HUMAN
Sequence: MAAGKSGGSAGEITFLEALARSESKRDGGFKNNWSFDHEEESEGDTDKDGTNLLSVDEDEDSETSKGKKLNRRSEIVANSSGEFILKTYVRRNKSESFKTLKGNPIGLNMLSNNKKLSENTQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQSSLDRKERKEYPPHVQKVEINPVRLSRLQGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQAITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKVPIDIIVNCDDSKHTYLQTNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSACSSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTLPRKARMKDQFGNSIINTPLKRRKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHDPVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKGVNKLTNLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVACTRTYEESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERRNHETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPKYEPNPHYHENAVIQKCSTVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDSNPGQEESDPRYKRNICSVKYSVKKINHTASENEEFNKGESTSQKVADRTKSENGLQNESLSSTHHTDGLSKIRLNYSDESPEAGKMLEDELVDFSEDQDNQDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQEDQSKEKRKHKDTYSTEAPLGEGTEQYVNSISD
What is the function of this protein?
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins.  Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors.  Deconjugates SUMO1 from RXRA, leading to transcriptional activation.  Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex.  Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation.  Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
What are the official names of this protein?
Sentrin-specific protease 6, SUMO-1-specific protease 1, Sentrin/SUMO-specific protease SENP6.
What is the protein family that this protein belongs to?
Belongs to the peptidase C48 family.
Protein: TRPA_CAMJJ
Sequence: MVDFRKFYKENANVAYTVLGYPNLQTSEAFLQRLDQSPIDILELGVAYSDPIADGEIIADAAKIALDQGMDIHSVFELLARIKTKKALVFMVYYNLIFSYGLEKFVKKAKSLGICALIVPELSFEESDDLIKECERYNIALITLVSVTTPKERVKKLVKHAKGFIYLLASIGITGTKSVEEAILQDKVKEIRSFTNLPIFVGFGIQNNQDVKRMRKVADGVIVGTSIVKCFKQGNLDIIMKDIEEIFKK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RS12_SALA4
Sequence: MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKRPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: VSP1_PROFL
Sequence: MVLIRVLANLLILQLSYAQKSSELVIGGDECNINEHPFLVALYDAWSGRFLCGGTLINPEWVLTAAHCDSKNFKMKLGAHSKKVLNEDEQIRNPKEKFICPNKKNDEVLDKDIMLIKLDSPVSYSEHIAPLSLPSSPPSVGSVCRIMGWGSITPVEETFPDVPHCANINLLDDVECKPGYPELLPEYRTLCAGVLQGGIDTCGFDSGTPLICNGQFQGIVSYGGHPCGQSRKPGIYTKVFDYNAWIQSIIAGNTAATCLP
What is the function of this protein?
Thrombin-like snake venom serine protease that clots fibrinogen (FGA) by releasing fibrinopeptide A.  According to PubMed:8585090, only cleaves rabbit fibrinogen, whereas no specificity is described in PubMed:3910643 (tests done on bovine fibrinogen).  Also acts as a C3 convertase that independently cleaves human C3 and kick-starts the complement cascade.  Also increases urokinase-type plasminogen activator (PLAU) and plasminogen activator inhibitor (SERPINE1) in cultured bovine pulmonary artery endothelial cells.  Dose-dependently inhibits collagen-induced platelet aggregation.
What are the official names of this protein?
Thrombin-like enzyme flavoxobin, SVTLE, Fibrinogen-clotting enzyme, Habutobin, Snake venom serine protease 1, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MCH_META3
Sequence: MLSVNLKSLPIVENMIEKAEEMNIEVIKLENGATVLDCGVNVMGSIEAGKAFTKICLGGLAHVGVSIAGTVSDEMVLPCVKVKTSHPAIATLGSQKAGWTINIGKFFAMGSGPARALAKIPKATYEEINYEDNADVAILCLEASQLPNEEVAEFVAEKCGVDVSKVYLLVAPTSSLVGSIQISGRVVENGTYKMLEALHFDVNKVKFAAGIAPVAPIIGDDLAMMGATNDMVLYGGRTYYYIESDENDDVEALCKALPSCSSQDYGKPFLETFKAANYDFYKIDKGMFAPAVVVINDMRTGKLVTYGKPHVDVLKKSLGYKELE
What is the function of this protein?
Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
What are the official names of this protein?
Methenyltetrahydromethanopterin cyclohydrolase, Methenyl-H4MPT cyclohydrolase.
What is the protein family that this protein belongs to?
Belongs to the MCH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_BACAH
Sequence: MALTQERKNEIIAQFRTHETDTGSPEVQIAVLTEQINTLNEHLRTHKKDHHSRRGLLKMVGKRRNLLTYLRNSDITRYRELITKLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RNPA_MESH7
Sequence: MQKIRSIKKNWEFQAIINKKNQIVTNYLIFYYVKSDFFEIGISVPKKFANAVKRNYYKRQIKNALYILWKKGEIFLNFRVVLIARKNFLPLSFETKYQKLAKIFKELKRNEK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: VPS10_COCP7
Sequence: MILRRLLLAGSLLLASFATAKKDGPKIEVTELEHEPKHLFYFEDSDVVMLQHKYDAYISTDAGVSWAPVKGPDDHMKGKVKAIYHHPYDRTKAYVLGQERTHWTTDDTGKSWREFTIDQALPRSGNPLSFHGKDSNKVILHTIECSGFICQMPALYTTDGFKSHKILTKAQHGCSWAISTPEFAAREEFPENVDNRILCMFTGLHSPIGTQKRLLYSDDFFEGDRGTEVPLNNGRPVSDIVSMVGVKKFLVAAARSPRTNELALYVSDDASRWHQALFDGHRLENNGYTILESTNYSIQVGVKTSGGFNPMSALFTSNSDGVSFTRNAEHLNANNLGYVDFEKIAGIQGIFLVNTVTNWEEIEEHHGGKKKIVSKISFDDGRTFHDIKAGDKNLHLHSVTHIHNTGRVFSSPAPGLVMGVGNVGDSLKEYDDGDLYVSDNAGITWWRALEDAHKYEFGDQGSVLVAVYDEGRTNKISYSLNHGKDWKTAELPVKIRARTLTTTPDSTSLKFLLLGTGKGSSERKHYVIALDFSDVHERKCSKDDFERWPARLNEKEEPDCLMGHKQFYRRRKGKSECFIGEEFKDPVPELERCKCTEEDFECDFNFVRSEDRKDCVPARSLPVPEGQCKKPEDKYTGSSGFRLIPGDDCIKEGGLELDKPKERSCSDTAKEPVSGEIGVSIQHFDANKPAEYYYMERPTLSKDKDETVMLLTDKLEVFMTKDHGKTWQQILAGKNIAKLWPHTYNNDIMYYVTGEKKVFLTKNRGDSFREFETKLPPNRDRLPVLAFHPDPERSEWLIWTGADNCERGGDCHSVAHYSTDGGDEWHTLMRYVGRCEFVGKGGVRKTDELIFCAQHENEDPKNKHFRLLSSENWFTNKKIHYKDILDFRTMAEFIIVAARAGKDSLKVGASIDGDTFADAEFPPNFDVKTQQAYTVLDSSTHSVWLHVTVHNVPDHQFGSIIKSNSNGTSYVLSLSNVNRNNADYVDFEKMQGLEGVALVNVVANVDEVVKGAAKKLRTMITHNDGAEWDYVRPPAMDADGRKYGCSPGKKGTAECGLHLHSYTERRDFRDTFSSPSAVGLMLAVGNVGDHLTLKSEGDTFITRDGGIEWHSVKKGNYIWEYGDQGSIIVIVPESKPTKTIFYTLDEGRTWIEFEFTKVEMQISDITTVPSDTSRNFLLWGTEVGSGAKPGFATVNLDFSGLKERSKKCVLKEEKPEADDYYIWEPKHPLLEDNCLFGHVARYHRKKPDSQCFNGGEFEKLHNVSTNCPCTRQDYECDYNYERQSDGSCALVEGLQPLDPKRICTEDPNAIEYYEPTGYRRIPLTTCEHGVKLDGFKAFPCPNKEKEFEKKHPGLRGVGLFFAIVIPIAAAAAVGYWVYNRWDGKFGRIRLGETSRSGSWLSRDSPLVVVPVAIIAGTVAVMSALPLLAASLWRSFRGWMPVGRGSSRPYSSRGAFAARRGDYVGVVEDEDELLGAEDFDGDEDEEV
What is the function of this protein?
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.  Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
What are the official names of this protein?
Vacuolar protein sorting/targeting protein 10, Carboxypeptidase Y receptor, CPY receptor, Sortilin VPS10, Vacuolar carboxypeptidase sorting receptor VPS10.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Prevacuolar compartment membrane; Multi-pass membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Protein: Y224_TREPA
Sequence: MRISAGVLNFLKVDLFKGVRHACAPLVWDAYPLK
What are the official names of this protein?
Uncharacterized protein TP_0224.