PharMolix/UniProtQA huggingface dataset:
Protein: NADK1_SYNP6
Sequence: MQLRQVIIAYKAGDPTSKAAADDCAHCLESQGIHVMLGPSGARDNPFPVFLASATEPIDLAIVLGGDGTVLAAARHLSDAGIPLLTFNVGGHLGFLTQPRDFFQPEAELWDRLRNDQYAVEQRMMLAASLHEGGRENREPISETYYALNDMCVKPAAPDRMSVCILEMEVDGEIIDQYQGDGLIVSTPTGSTCYTAAAHGPIVHPGVDALAVTPICAMSLSSRPIVIPPRSVVSVWPLGTQDPTIKLWMDGVLATSIWPGQRVDIRMAEKPAQFLVLDSDRSFYRILREKLQWAGAVIHYNNNFRN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase 1, ATP-dependent NAD kinase 1.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PALA_CANGA
Sequence: MTELIDIPFLLTKDCSADLEDRLRFCIETGSLYQTHESFKKDIGEIVNTRQALVNLKFGDSKLLTKYYGYLECLLKKIDPEALAFSWSYTNYTIFEGNVFRDENLLGERRNILFNLGIAYYQSAKHIDDYKNNLPLVCDYLKRSAGCFEILSQRTKERNSEKAIISETMLKALKSMCMGLAQETVWFKSLAAKKDLLTSKLAYKCFEYFQESLNSFQLVGQSTEYIKLILVFVESKMLYFKAVCVYRLAQSIESIADNVGVVIRCLSIAVAALTNSKLESTVVFKNKCLEMLRQLEKDNDFIYLKHVPSHLQFSDFVKLYKLDSMKDLIVLPDLTEIAPSMLDQILFRNLLPIEIMDYGTSYNEKQDIYVLQHFVEPINLLNIQLDEELASFFEIDPQHIVNAHNKTKSFVTRKELDVIGQSFGDLESNAINIETQLANITSYLDLEIKTYEEDKQQYGDVWTIVDARDVTKEFYEKVEKLRQYLEIGRNINLETQELFASIDKSLVTSRTSKAHLTAQYNDPFLNKIEALKKRRERFISEIEKKSYENRIISKLIMYYKETDDIPGTISEREEIFDNIYSKHMKVFAVDMKYIEDCKNENYGLIKEIEEYKSRTNFNNEDRSSDPRTQYIQDVRQSLASLDDVKTQLKKGTAYYQQLIEKVNELVQVIVGFLEARRNDRERLLNEISTAA
What is the function of this protein?
Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.  May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity).
What are the official names of this protein?
pH-response regulator protein palA/RIM20.
What is the protein family that this protein belongs to?
Belongs to the palA/RIM20 family.
Protein: TGT_XENLA
Sequence: MAATKSHALVHRVLAECPVTKARACELQMPHGQVKTPVFMPVGTQGTMKGVTADQLRNLGCEICLGNTYHLGMRPGPEIMKKASGLHGFMNWDRNLLTDSGGFQMVSLVELSKVTEEGVQFRSPYDGKEILLTPEKSIEIQNALGSDIMMQLDDVVSSTISGPRVEEAMHRSIRWLDRCIAANGNPDRQNLFAIIQGGLDAELRKQCLQEMTKRDVPGFAIGGLSGGEEKDHFWRMVTLSTDHLPRDKPRYLMGVGYATDLVVCVALGCDMFDCVFPTRTARFGSALVPWGSLQLKSKQFAKDFQPIDKNCDCPTCQRYSRSYINALFKSDTAAMHHITIHNIAYQLNLMRSVRESILQGRFPQFVQDFMKTMYGNKDKYPQWAVAALETVGITLQ
What is the function of this protein?
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
What are the official names of this protein?
Queuine tRNA-ribosyltransferase catalytic subunit 1, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Weakly associates with mitochondria, possibly via qtrt2.
Protein: BUB3_YEAST
Sequence: MQIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSDDTFKTNAAIDQTIELNASSIYIIFDYEN
What is the function of this protein?
Required for cell cycle arrest in response to loss of microtubule function.  Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.  Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20.  The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism.
What are the official names of this protein?
Cell cycle arrest protein BUB3.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BUB3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRP2_YEAST
Sequence: MSSITSETGKRRVKRTYEVTRQNDNAVRIEPSSLGEEEDKEAKDKNSALQLKRSRYDPNKVFSNTNQGPEKNNLKGEQLGSQKKSSKYDEKITSNNELTTKKGLLGDSENETKYASSNSKFNVEVTHKIKNAKEIDKINRQRMWEEQQLRNAMAGQSDHPDDITLEGSDKYDYVFDTDAMIDYTNEEDDLLPEEKLQYEARLAQALETEEKRILTIQEARKLLPVHQYKDELLQEIKKNQVLIIMGETGSGKTTQLPQYLVEDGFTDQGKLQIAITQPRRVAATSVAARVADEMNVVLGKEVGYQIRFEDKTTPNKTVLKYMTDGMLLREFLTDSKLSKYSCIMIDEAHERTLATDILIGLLKDILPQRPTLKLLISSATMNAKKFSEFFDNCPIFNVPGRRYPVDIHYTLQPEANYIHAAITTIFQIHTTQSLPGDILVFLTGQEEIERTKTKLEEIMSKLGSRTKQMIITPIYANLPQEQQLKIFQPTPENCRKVVLATNIAETSLTIDGIRYVIDPGFVKENSYVPSTGMTQLLTVPCSRASVDQRAGRAGRVGPGKCFRIFTKWSYLHELELMPKPEITRTNLSNTVLLLLSLGVTDLIKFPLMDKPSIPTLRKSLENLYILGALNSKGTITRLGKMMCEFPCEPEFAKVLYTAATHEQCQGVLEECLTIVSMLHETPSLFIGQKRDAAASVLSEVESDHILYLEIFNQWRNSKFSRSWCQDHKIQFKTMLRVRNIRNQLFRCSEKVGLVEKNDQARMKIGNIAGYINARITRCFISGFPMNIVQLGPTGYQTMGRSSGGLNVSVHPTSILFVNHKEKAQRPSKYVLYQQLMLTSKEFIRDCLVIPKEEWLIDMVPQIFKDLIDDKTNRGRR
What is the function of this protein?
Involved in pre-mRNA splicing.  Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction.  Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing.  Capable of hydrolyzing nucleoside triphosphates in the presence of single-stranded RNAs such as poly(U).
What are the official names of this protein?
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2, Pre-mRNA-processing protein 2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MCM2_MOUSE
Sequence: MAESSESLSASSPARQRRRISDPLTSSPGRSSRRADALTSSPGRDLPPFEDESEGLLGTEGPMEEEEDGEELIGDGMERDYRPIPELDVYEAEGLALDDEDVEELTASQREAAERTMRQRDREAGRGLGRMRRGLLYDSSEEDEERPARKRRHVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATIILANHVAKKDNKVAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKKDEGLTNGGTLEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMMESFIDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNRFGAQQDTIEIPEKDLMDKARQINIHNLSAFYDSDLFKFNKFSRDLKRKLILQQF
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  Required for the entry in S phase and for cell division (PubMed:10567526).  Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (By similarity).
What are the official names of this protein?
DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: KDSB_ACIBT
Sequence: MKHIVIPARFSSSRLPGKPLLLIHDRPMILRVVDQAKKVEGFDDLCVATDDERIAEICRAEGVDVVLTSADHPSGTDRLSEVARIKGWDADDIIVNVQGDEPLLPAQLVQQVAKLLVDKPNCSMSTLCEPIHALDEFQRDSIVKVVMSKQNEALYFSRATIPYDRDGAKRDEPTLHTQAFRHLGLYAYRVSLLQEYVTWEMGKLEKLESLEQLRVLENGHRIAIAVAEANLPPGVDTQADLDRLNNMPVESFE
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRS2_RAT
Sequence: MECLRYLPRLLPRAAQSRSALCMAAVRLSLAACCGRATPLTSGSQKAPSTPRTAGDVYRFRTSDASQATLASVAQVFAVTKFDKEGNVTSFERKKTELYHELALQARDLRFQHVMSITTRNNRIIMRMEYLKAVITPEYLLILDYRNLNLEHWLFRELPSQLAGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLILETLDALVDPKHSSVDRSKLHVLLQNGKSLSELETDIKIFKESILELLDEEEMLEELCLTKWSDPHVFEQSSTGIDHAEEMELLLENYYRLADDLSNEARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDHRVFWLITGIMFMGSGLIWRRLLSFLGRQLEAPLPPVMASLPKKTLLADRRMDVKNSLRPEGLGAGRTILASR
What is the function of this protein?
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix.  Required for normal expression of the mitochondrial respiratory complex I subunits.
What are the official names of this protein?
Magnesium transporter MRS2 homolog, mitochondrial, MRS2-like protein.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PARB_XYLFT
Sequence: MNKPSLPLKKRGLGRGLEALLGSKGGSSVPPTVAQEQLPGEVLRTLQTTQLQPSKYQPRREMSEAKLAELADSIKAQGVIQPIIVRELDVDMFEIVAGERRWRASQLAGLTEVPVIVRELDDRTVVAMALIENIQREDLNPLEEAQALQRLIDEFSLTHAEAAEAVGRSRAAVSNLLRLLELPLGIRTLLESHQLEMGHARALLTLTPELAAKLAKEAADQGWSVREVEHRAQQFAAGKVPDIRDKKSKSLASAPAQPDIASLETELSERLGTKVAINHGRTGKGKLVIHYTDLDVLDGVLERLRARAVG
What is the function of this protein?
Involved in chromosome partition.  Localize to both poles of the predivisional cell following completion of DNA replication.  Binds to the DNA origin of replication (By similarity).
What are the official names of this protein?
Probable chromosome-partitioning protein ParB.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
Protein: THIM_STRA3
Sequence: MYLEQLKEVNPLTICITNNVVKNFTANGLLALGASPAMSECIEDLEDLLKVANALLINIGTLTKESWQLYQEAIKIANKNQVPVVLDPVAAGASRFRLEVSLDLLKNYSISLLRGNGSEIAALVGEKQASKGADGGKVADLESIAVKANQVFDVPVVVTGETDAIAVRGEVRLLQNGSPLMPLVTGTGCLLGAVLAAFIGSSDRSDDLACLTEAMTVYNVSGEIAEKVAKGKGVGSFQVAFLDALSQMKSEMIMDK
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: PSD_PSEP1
Sequence: MKSRLFIISQYLLPHHLLSRLAGCIAECRVRWFKNAFTAWFAKRYQVNMSEALVEDLSAYEHFNAFFTRALKPGARPLDETPGAILCPADGAVSQLGPIEHGRIFQAKGHGFSAQELLGGDPAMAAPFMGGEFATIYLSPKDYHRVHMPLAGTLREMVYVPGRLFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASIETVWAGLVTPPKRELKTFRYDEASRTPIHLEKGAELGRFKLGSTAIVLFGPEQVKWAESLGAGSAVRMGQQLAAPVQA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AMSE_ERWAM
Sequence: MFSVLISLYNKEKPENLEQCLESLHQQTLNADEIVLVYDGPVSESLKAVATRWANLLPLVIVPLEKNLGLGKALNAGLERCTHNVVARMDTDDICLPERFEKQISYMESHPEVVLSGAAVIEFDEHGKERLKRLPLSNNDIHQFARMKNPFNHMCVVFRKDKVISAGSYQHHLYMEDYNLWLRIMSLGHPVANLPDVLMKVRAGSDMVNKRRGWNYIKSEVQLYRLKLALKQTGFIRGTLYFLIRTMTRLMPVKVMQFLYEKDRKG
What is the function of this protein?
Involved in the biosynthesis of amylovoran which functions as a virulence factor.
What are the official names of this protein?
Amylovoran biosynthesis glycosyltransferase AmsE.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: RL13_BRUAB
Sequence: MATFSQKPAEVVKKWVLIDAEGLVVGRLASLVANRLRGKHKATFTPHVDDGDNVIIINADKVVLTGKKYTDKKYYWHTGHPGGIKERTARQILEGRFPERVLEKAIERMIPRGPLGRRQMKNLRVNAGPNHQHEAQQPEVLDVAALNRKNKGNA
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: Y1176_MYCLE
Sequence: MTRPETPQAPDFDFEKSRTALLGYRIMAWTTGIWLIALCYEIVSHLVFHHEIRWIEVVHGWVYFVYVLTAFNLAIKVRWPIGKTVGVLLAGTVPLLGIIVEHFQTKDVKTRFGLRHSRT
What are the official names of this protein?
Uncharacterized protein ML1176.
What is the protein family that this protein belongs to?
To M.tuberculosis Rv1342c.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLC7B_CAEEL
Sequence: MDVEKLNLDNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKKKYPYGAGGVGSNRPVTPPRNAPAAQPKKGAKK
What is the function of this protein?
Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis.  During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA-mediated genome silencing pathway (PubMed:30921322).  Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment (PubMed:18923084).  Dephosphorylates histone H3 at 'Ser-10' (Probable).  Dephosphorylates histone H3 at 'Thr-3' (Probable).  Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation.  Promotes small RNA-mediated genome silencing over multiple generations (PubMed:30921322).  Essential for embryogenesis.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-beta, CeGLC-7-beta, Glc seven-like phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes to nuclei in the mid-pachytene to diplotene phase of meiosis.
Protein: PPNP2_PSYA2
Sequence: MPSVNNYFDNKVTSIAFQTATKPATVGVMEIGDYEFGTSEFETMTVVSGALTVKLPESDEWQTFNAGAQFTVDANQKFQVKVEVETAYLCTYGE
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase 2, Adenosine phosphorylase 2, Cytidine phosphorylase 2, Guanosine phosphorylase 2, Inosine phosphorylase 2, Thymidine phosphorylase 2, Uridine phosphorylase 2, Xanthosine phosphorylase 2.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: FAF2_HUMAN
Sequence: MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE
What is the function of this protein?
Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460).  By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).  Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).
What are the official names of this protein?
FAS-associated factor 2, Protein ETEA, UBX domain-containing protein 3B, UBX domain-containing protein 8.
Protein: DPF1_CHICK
Sequence: MAAAVHGALKAVGEDFYRDAIEHCRSYNARLSAERSTRLPFLDAQTGVAQSDCYIWMERSHRGPGLSPGQIYSYPARCWRKKRRLNILEDPRLRPLCDAPQKKELGSAVAEGAVLEALLCAEPPKEPKEEEALLDCQKPPPGDFAHDAEGDEMEDDAPRRKNKAKGKTYGLGAVRKRQDAAALEDRDKPYVCDICGKRYKNRPGLSYHYTHTHLAEEEGEESAERHPLPFQRRNHHKQFYKELNWVPESQRRHAAAAGRRSEGPCDFCVGGAVRRAALGHEEMIACADCGRAGHPSCLQFTLAMAAAARSYRWQCIECKNCSLCGSAENDEQLLFCDDCDRGYHMYCISPPVAEPPEGTWSCHLCLRQLKDKAAAFITLT
What is the function of this protein?
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor.  Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development.
What are the official names of this protein?
Zinc finger protein neuro-d4, D4, zinc and double PHD fingers family 1.
What is the protein family that this protein belongs to?
Belongs to the requiem/DPF family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PURA_WOLSU
Sequence: MKADLVVGIQWGDEGKGKIVDSMASAYDVVVRYQGGHNAGHTIVVDGKKIALHLIPSGILYADCKNVIGNGVVVNPEALLKEMKQFEALEGRLFVSDKAHMILPYHEMLDQAREKLMEERAIGTTGKGIGPAYSDKISRNGIRMGELRDIPKLVEKIMEYQEAHAYLSDIYGVKLLGREEITERMSDYAKRLLPFIVDTTKLLWDAMDRGQRILLEGAQGSMLDIDHGTYPFVTSSTTTASGACSGTGLAPKHIGEVVGIAKAYCTRVGNGPFPTEDFGSEGNLLREKGKEFGTTTGRPRRCGWFDAIAVRHACRLNGCENLALMKLDVLDGFPEVKVCVAYLYEGKEIDYIPYDCEGVTPVYKSFAGWDHSEGIREFDALPKSAKEYVLEIEKITGARVSIISTGPDRKDTIRR
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_METM6
Sequence: MELIVKEESKTDYNYGSDPYKRDIKTLLNTGLVVIDKPSGPTSHEVAAWVRNMLNLVKAGHGGTLDPKVTGALPVALGNTTKCVPIWHIPPKEYVCLMHLHDDAKLEDIENIFKEFTGRIHQRPPLKAAVKRSLRIRKIYEIEILEIDGRDILFRTKCQSGTYLRKLVDDMGEALGTSAHMQELRRTISGPFYENEAVYLQDLLDAYISWKEDGNEEELRKLVKPLEYGLQHLKKIIVKDSAVDAVCHGATLYSSGVSKIEKGIGTDEVVLIETLKGEAVAVGKPLMNTKDMLKTEEGEVVEITRVIMEPGIYPRIWKKRNKNDKSKPESKKN
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
Protein: CF223_HUMAN
Sequence: MMPLAEAGALAQGGGPSATEWACILRRKTPRHKQPTLLMVRASRRSGKTSAVLKAGRQSVSGRKNSTSKDLVTLGASSLREERGHPLHPRHRKAVHLRTRGRTRGWVQTLARMSRRTRGPVERAAAAAAAAAGGDAGHAPFPPPPAADGARAPRSPGQVTPRGLRLRLPRRESLLRGLCRPLRPLLGFRESDSAKPASLRLLQHTPSARRNYRIAGARLMRSNYPPPLSSAALRGAGPTRRN
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC03040.
Protein: NLP28_CAEEL
Sequence: MISTSSILILVFLLACFMATSAQWGYGGYGRGYGGYGGYGRGMYGGYGRGMYGGYGRGMYGGWGK
What is the function of this protein?
May have antimicrobial activity.
What are the official names of this protein?
Neuropeptide-like protein 28.
What is the protein family that this protein belongs to?
Belongs to the YARP (YGGW-amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y053_STAA8
Sequence: MIKRVNKLVLGISLLFLVISITAGCGMGKEAEIKKSFEKTLSMYPIKNLEDLYDKEGYRDDQFDKNDKGTWIVNSQMAIQNKGEALKIKGMLLKIDRNTRSAKGFYYTNEIKTEKYEVAQDNQKKYPVKMINNKFISTEEVKEENIKKEIENFKFFAQYSNFKDLMNYKDGDISYNPEVPSYSAQYQLTNDDYNVKQLRKRYDIPTNKAPKLLLKGTGNLKGSSVGYKKIEFTFLENKNENIYFTDSLHLEPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SAOUHSC_00053.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RSC2_YEAST
Sequence: MMPDDNSNSSTQNSSALYKDLRKEYESLFTLKEDSGLEISPIFNVLPPKKDYPDYYAVIKNPVSFNTLKKRIPHYTDAQQFMNDVVQIPWNAKTYNTRDSGIYKYALVLEKYLKDTIYPNLKEKYPQLVYPDLGPLPDEPGYEEFQQKLREKAEEVARANAARAESSSSMNSTEAARRLRKTRTSVKRESEPGTDTNNDEDYEATDMDIDNPKDADFPDLIRKPLININPYTRKPLRDNRSTTPSHSGTPQPLGPRHRQVSRTQVKRGRPPIIDLPYIQRMKNVMKVLKKEVLDSGIGLTDLFERLPDRHRDANYYIMIANPISLQDINKKVKTRRYKTFQEFQNDFNLMLTNFRISHRGDPESIKISNILEKTFTSLARFELSKPDRSFIPEGELRYPLDEVIVNNISYHVGDWALLRNQNDPQKPIVGQIFRLWKTPDGKQWLNACWYYRPEQTVHRVDRLFYKNEVMKTGQYRDHLVSNLVGKCYVIHFTRYQRGNPDMKLEGPLFVCEFRYNESDKIFNKIRTWKACLPEEIRDLDEATIPVNGRKFFKYPSPIRHLLPANATPHDRVPEPTMGSPDAPPLVGAVYMRPKMQRDDLGEYATSDDCPRYIIRPNDSPEEGQVDIETGTITTNTPTANALPKTGYSSSKLSSLRYNRSSMSLENQNAIGQQQIPLSRVGSPGAGGPLTVQGLKQHQLQRLQQQQHQYQQQKRSQASRYNIPTIIDDLTSQASRGNLGNIMIDAASSFVLPISITKNVDVLQRTDLHSQTKRSGREEMFPWKKTKGEILWFRGPSVIVNERIINSGDPHLSLPLNRWFTTNKKRKLEYEEVEETMEDVTGKDKDDDGLEPDVENEKESLPGPFVLGLRPSAKFTAHRLSMLRPPSSSS
What is the function of this protein?
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA.  The reaction requires ATP and involves an activated RSC-nucleosome intermediate.  Remodeling reaction also involves DNA translocation, DNA twist and conformational change.  As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton.  This subunit is involved in meiotic sporulation through regulating IME2 expression, and is also essential for 2-micron plasmid maintenance and for normal REP1 protein localization.
What are the official names of this protein?
Chromatin structure-remodeling complex subunit RSC2, RSC complex subunit RSC2, Remodel the structure of chromatin complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the RSC1 family.