PharMolix/UniProtQA huggingface dataset:
Protein: ISPG_CAMLR
Sequence: MEYQRYKTRQIKVGDVLIGGDAPISVQSMLFTKTRDVEGCLEQLNRLYFAGANIVRLACLDMADARALKEIKAKSPLPLIVDIHFNHKLAVFCAEFIDGVRINPGNIGSKENIKEVVQACKQRKIPIRIGVNHGSIEKQFSDKYGYNIEAMLGSALYNIKLLEDLDFFDIKISMKTSDVQNTIKAYEALRPLCDYPFHLGVTEAGTKFHSTVKSSIALGNLLLKGIGDTMRVSMTGELEEEIRVARAILQDSGVQKSGVNIISCPTCGRIQSDLIKAIKIVEEKTKHIKEPLNISVMGCVVNALGEAKGADVAIAFGKNQGLVIRHGEVVAKLKEDELVDRFLLEVEDEVKLREKD
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RDRP_I82A4
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEGMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNESTRKRIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTRTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEEFRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: C71BA_ARATH
Sequence: MTVLWFVSLILLISILLVAVKHSKRRWVRQPPSPPGLPIIGNLHQLGELPHQSLCKLSKKYGPVMLLKLGRVPTVIVSTPETAKQVLKDYDLHCCSRPSLEGTRKLSYNYLDIAFSRFDDYWKELRKLCVEELFCNKRINSIQPIKEAEMEKLIDSIAESASQKTLVNLSDTFLSLNVNVICKAVFGVNFQGTVLNNDKFQDLVHEALEMLGSFSASDFFPYVGWIVDWFTGLHARRERSVRDLDAFYEQMIDLHLQKNREESEDDFVDLLLRLEKEEAVLGYGKLTRNHIKAILMNILLGGINTSAITMTWAMAELIRNPRVMKKVQSEIRAQIGKNNKTRIISLDEINHLSYLNMVIKETCRLHPVAPLLVPREVISEFKINGYTIQPKTRLHVNVWAIGRDPEIWKDPEEFLPERFMDCDIDVKGQDYELLPFGSGRRICPAVYMGITTVEFGLANLLYHFDWKLPEGVAVEDIYMDEASGLTSHKKHDLLLVPVKSLV
What are the official names of this protein?
Cytochrome P450 71B10.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ATP6_HELP2
Sequence: MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFFISLGASRKMQMVPMGLQNVYESIISAILSVAKDIIGEELARKYFPLAGTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYYHFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRIVSLSFRLFGNIKGDDMFLLIMLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KHSE_PETMO
Sequence: MIRVKVPATTANIGPGFDSLGIALQLYNIIEVEEINFGLEINIPVEDQAYIETNEHNLVYQAMKRLFDAVNIHPKGLRINLINNIPIARGLGSSAACIVGGLVVANELLNNPLKKEEIIYLAATMDGHTDNILPAFVGGLTVGSLLEKEVKYVKMDLPTQLKLLAIIPDFHFSTKKARSLLPKNVPIEDAVFNISRVGLLVASLVTSHFENLSEATKDKIHQPYRKDFIPYWEEITSKLMKIGTKGYFLSGSGPTIMGILDGDYKNIEDEMVNFLSHFDQGYKVTVLDVCHNGLEVINDEGSNGCYR
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C6A21_DROME
Sequence: MSVGTVLLTALLALVGYLLMKWRSTMRHWQDLGIPCEEPHILMGSMKGVRTARSFNEIWTSYYNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKEFNKFTDRGFFHNPEDDPLSGQLFLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAKSPVVEVRELLARFTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNLARRLHMKMTAEPIERFFMRIVRETVAFREQNNIRRNDFMDQLIDLKNKPLMVSQSGESVNLTIEEIAAQAFVFFAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPMTYNKEMFLIASNSGIYLKAERV
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 6a21, CYPVIA21.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: MGRB_SALSV
Sequence: MKKFRWVVLGIVVVVCLLLWAQVFNIMCDQDVQFFSGICAINKFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RIMO_ERYLH
Sequence: MSTITSAIPDQKKVGMVSLGCPKALVDSERILTRLRADGYAMSADYAGADVVLVNTCGFLDSAKEESLAAIGEAIAENGRVIVTGCMGEEADAIRAAHPQVLAVTGAHQYEAVVGAVHEHAPPSQGPYVDLIPQPSEADIKLTPRHYSYLKISEGCNHSCAFCIIPQLRGKLASRRIDAVLREAEKLVAAGTKELLVISQDTSAYGVDTRHEAKSWKGREVRAHMTDLARELGQLDTGDGTPPWVRLHYVYPYPHVDAVIPLMAEGLLTPYLDIPFQHASPKVLKAMKRPANEAKVLERLKGWRAICPEIAVRSSFVVGFPGETEDDFRYLLEWLEEARLDRVGAFRFEPVEGAAANALPDPVPEEVKEERYARIMELTARISAEKLQRKIGRALPVIIDEVGEPDEDGDIGATGRSQADAPEIDGAVYLRNVPATLAAGDIVQVTVEDADEHDLFGAIARV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOB3B_BOVIN
Sequence: MSIALKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNSGVDLKAAVQLPSGEDQNDWVAVHVVDFFNRINLIYGTICEFCTERTCPVMSGGPKYEYRWQDDLKYKKPTALPAPQYMNLLMDWIEVQINNEDIFPTCVGVPFPKNFLQICKKILCRLFRVFVHVYIHHFDRVIVMGAEAHVNTCYKHFYYFVTEMNLIDRKELEPLKEMTSRMCH
What is the function of this protein?
Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
What are the official names of this protein?
MOB kinase activator 3B, Mob1 homolog 2b, Mps one binder kinase activator-like 2B.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
Protein: CYBR1_DANRE
Sequence: MENYPQFLLFFILASVVGIVSIAVALSWVLHYREGLGWDGGAAEFNWHPLLMVIGFIFLQGIAIVVYRLPWTWRCSKQMMKLIHAGLHILAFILAVISVVAVFVFHNAKNIPNMYSLHSWVGLAAVVLYPSQIVLGIAVYLIPVTPVRVRAALMPLHIYSGLFIFISVIAAALMGITEKLIFSLKSPAYKDSPPEAVLVNVLGLLIAAFGALVVWIATRSAWKRPREETAQTLSNNTTSPEEIKVGTDMTTTS
What is the function of this protein?
Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+).  It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration (By similarity).  May also function as a cupric transmembrane reductase (By similarity).
What are the official names of this protein?
Plasma membrane ascorbate-dependent reductase CYBRD1, Cytochrome b reductase 1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Protein: PYRG_BLOPB
Sequence: MRVNYIFVTGGVVSSLGKGIATASLAAVLEARGLSVTIIKLDPYINMDPGTISPVQHGEVFITEDGAETDLDLGHYERFIRTKMRHHNNFTAGKIYADVLRKERRGDYLGATIQIIPHVTDTIKKWLIAGAFGHDVLLVEIGGTVGDIESLPFLEAIRQMVMEVNREQTLYIHLTLVPFIAVSGELKTKPTQHSVKELLSIGIQPDILICRSDRVISNSERKKISLFCNVPKQAIIALQDVDSIYKIPALLKDQGLDNYICKRFNLNCPEANLSDWEEVIYYQEHPIGEVTVGMVGKYIELVDAYKSVTEALKHAGIKNRFIVNIRLINSQDVEKLGIEKTLKGLDAILVPGGFGYRGVEGKILSAQYARENNIPYFGICLGMQVALIEFARHVAGMPEANSTEFVTNCKCPVIALITECKDENGIFITHNDNTNLGGTMRLGNQACYLIKGSLTHQIYGKSTILERHRHRYEVNNMLLKHITHAGLSCVGFSKKNNLVEVIEYPNHPWFIGSQFHPEFNSTPREGHPLFIGFIKAAIEYQHRHNKLI
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: CCPA_STAAC
Sequence: MTVTIYDVAREARVSMATVSRVVNGNQNVKAETKNKVNEVIKRLNYRPNAVARGLASKKTTTVGVIIPDISNIYYSQLARGLEDIATMYKYHSIISNSDNDPEKEKEIFNNLLSKQVDGIIFLGGTITEEMKELINQSSVPVVVSGTNGKDAHIASVNIDFTEAAKEITGELIEKGAKSFALVGGEHSKKAQEDVLEGLTEVLNKNGLQLGDTLNCSGAESYKEGVKAFAKMKGNLPDAILCISDEEAIGIMHSAMDAGIKVPEELQIISFNNTRLVEMVRPQLSSVIQPLYDIGAVGMRLLTKYMNDEKIEEPNVVLPHRIEYRGTTK
What is the function of this protein?
Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.
What are the official names of this protein?
Catabolite control protein A.
Protein: F16PA_BORPA
Sequence: MKRKTLTQYLVEQQRSAQALGPEVRLLIEVVARACKAISHAVSKGALGGVLGSLESENVQGEVQKKLDVLSNEILLEANEWGGHLAAMASEEMETIHLIPNRYPKGEYLLLFDPLDGSSNIDVNVSIGTIFSVLRAPHRVAGADVCEQDFLQPGSQQVAAGYAVYGPQTMLVLTIGNGVVGFTLDREMGSWVLTHESMRIPEDTKEFAINMSNMRHWAPPVKRYIDECLAGKTGPLGKDYNMRWIASMVADVHRILTRGGIFMYPWDAREPGKAGKLRLMYEANPMGLIVEQAGGAAIDGTGRILDIQPDKLHQRVSVILGSKNEVERVGRYHAEAHAS
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNT_YERE8
Sequence: MKLLKGSGAALLALFFALVYLLPINSRLLWQPDETRYAEISREMLQRGDWVVPHLLGIRYFEKPIAGYWFNNISQWIFGDTNFAVRFGSIFSTALSAVFVYWLATLLWRNRSTSFLAALIYLSMLLVFSIGSYAVLDPMISLWLTASMVCFYLTLRAETAKQKIGAYLLLGLACGMGFMTKGFLALAVPVISVLPIVIQQKRVKELIIFGPIAIVGAVILSLPWALAIAQREPDFWHYFFWVEHIQRFAEKDAQHKAPIWYYLPILCLGVLPWLGLLPAALLKGWRERVARPELFFLLSWVLMPLIFFSVAKGKLPTYILPCMAPLSLLMAAYATDCANKMHMRALKVNGAINLIFGFICALAILVIGMGWVGHLVAYGPQEHQKVILATIAFAGWGIVGFATMRNNARHWHWAAACPLLFILLVGYLIPQQVIDSKQPQNFIQNNFNELSSSRYVATDSVGVAAGLAWELKRSDILMFSEKGELSYGLNYADSGDHYISAQDFSDWLVHARQKGDVSLVIQLSRNEKIPDSLPAADKVSLMNRLALLWYKKTP
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IFT20_HUMAN
Sequence: MAKDILGEAGLHFDELNKLRVLDPEVTQQTIELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKMQLERYRVEYEALCKVEAEQNEFIDQFIFQK
What is the function of this protein?
Part of intraflagellar transport (IFT) particles involved in ciliary process assembly (PubMed:17604723).  May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004).  Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway.  Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719).  Essential for male fertility.  Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.  May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity).  Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).
What are the official names of this protein?
Intraflagellar transport protein 20 homolog, hIFT20.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm. Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia. Detected in the Golgi apparatus of round spermatids and late spermatocytes. Also detected in the manchette of step 10-12 spermatids. In step 14 spermatids, found in the basal body of the sperm tail. Localization in the manchette of elongating spermatids is dependent on SPAG17.
Protein: MNME_RHIE6
Sequence: MAMLNDTIYALSSGAPPSGVSVIRVSGTLTRDILFQLVGSVPAARTASYRTIRTRYDQPVDSGLVLFFPGPNSFTGEDAAELQIHGSKAVLAALFRELGDIPGVRMAMEGEFSRRAFENGKLDLVEVEGLADLIGAETEMQRRLAVEQSAGGVSAIYDSWAERLTRARALIEAELDFPDEDDVPGSVSDMVWADMARLRHDIALHLEAASAGEIIRDGFKVVIAGAPNAGKSSLMNALAKREVAIVTDIAGTTRDVLHVDLDIDGYLVKLYDTAGLREAEDRVEIEGVRRARVALRDADLVLLLVDMSNPIIPADLEQALPHVTVGTKKDLIETASDRYDLQISTTTGEGLPELRDLIGRVVKERYGGQSLAIPSRQRHKDSLAKCLAALDAAISQGSANLELRTEQLRLAAEYLGRITGRVDVEQLLDVIFSEFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_SALTY
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETALPLEEIAPAPRHVQENRIAAGRNHFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQPGYQKQQGEVYRTLLQTPTASPAPESVTPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQSPVCAQPLLIPLRLKVSADEKAALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: HDAC4_HUMAN
Sequence: MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.  Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.  Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).
What are the official names of this protein?
Histone deacetylase 4, HD4.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity).
Protein: BIOB_YEAST
Sequence: MMSTIYRHLSTARPALTKYATNAAVKSTTASSEASTLGALQYALSLDEPSHSWTKSQLKEIYHTPLLELTHAAQLQHRKWHDPTKVQLCTLMNIKSGGCSEDCKYCAQSSRNDTGLKAEKMVKVDEVIKEAEEAKRNGSTRFCLGAAWRDMKGRKSAMKRIQEMVTKVNDMGLETCVTLGMVDQDQAKQLKDAGLTAYNHNIDTSREHYSKVITTRTYDDRLQTIKNVQESGIKACTGGILGLGESEDDHIGFIYTLSNMSPHPESLPINRLVAIKGTPMAEELADPKSKKLQFDEILRTIATARIVMPKAIIRLAAGRYTMKETEQFVCFMAGCNSIFTGKKMLTTMCNGWDEDKAMLAKWGLQPMEAFKYDRS
What are the official names of this protein?
Biotin synthase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ARGB_MYCBO
Sequence: MSRIEALPTHIKAQVLAEALPWLKQLHGKVVVVKYGGNAMTDDTLRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIEGDFKGGFRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGITGEDAQLFTAVRRSVTVDGVATDIGLVGDVDQVNTAAMLDLVAAGRIPVVSTLAPDADGVVHNINADTAAAAVAEALGAEKLLMLTDIDGLYTRWPDRDSLVSEIDTGTLAQLLPTLESGMVPKVEACLRAVIGGVPSAHIIDGRVTHCVLVELFTDAGTGTKVVRG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STR10_ARATH
Sequence: MTVLLPQLNHIHKLPVVLNRRLRQSYRLPVISAVSGKELILSGKVRAVEPKEANAVVASEGYILLDVRPAWEREKARVKGSLHVPLFVEDPDNGPITLLKKWIHLGYIGLWTGQRFTMINDEFALRVVEAVPDKESKVLVVCGEGLRSLAAVSKLHGEGYKSLGWLTGGFNRVSEGDFPEIEGTEELRFATIGGVSFYLLKLLVLLPSFGQKSR
What are the official names of this protein?
Rhodanese-like domain-containing protein 10, Sulfurtransferase 10, AtStr10.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: BAMA_SALPK
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGNTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTLSDIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAKIQQINIVGNHAFSTEELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYITVNITEGDQYKLSGVQVSGNLAGHSAEIEKLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSQPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDSVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYSVGINGTKNDYQTYSELSVTNPYFTVDGVSLGGRIFYNDFEADDADLSDYTNKSYGTDVTLGFPINEYNTLRAGLGYVHNKLSNMQPQIAMDRYLESMGDPDASDFAADDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVSLDTATYVPIDNDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYKNGAHTSWDDNDDYEDCTQESGCKSDDAVGGNAMAVASLEFITPTPFISEKYANSVRTSFFWDMGTVWDTNWDPSSAPSDVPDYSDPGNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: MSHD_SALTO
Sequence: MNSTEPDSDRVTRTDRLNAPEIADVQALARAAGDADGADPFDEHTLLRLRDPHAPTHHLTARTANGTLTGYAHLDITNPTSGTGVELAVHPAYRRRGTGRALARSVRAAVTGPLRAWAHGDHPSAAALAVDLDYRRARVLWQLRRPLTAPIPEPPLPDGVTLRAYRPGADDDAWLALNAKAFADHPEQGQWTAADLQARRDEPWFDAAGFLLAVDPAGQLLGFHWTKIHERPGSARIGEVYVLGVDPTAHGGGLGKALTAAGLAYLRDQRGLDRVMLYVDESNTAAVALYERLGFARWSAHVNYQLG
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: Y371_CLOB1
Sequence: MRIGFDHEKYLEEQSKYILERVNNYDKLYLEFGGKLLFDLHAKRVLPGFDENAKIKLLHKLKEKVEIIICLYAGDIERNKIRGDFGITYDVDVLRLIDDLRGYDLEVNSVVITRYSGQPATNIFINKLERRGIKVYKHEATKGYPTDVDTIVSDEGYGKNPYIETTKPIVVVTAPGPGSGKLATCLSQLYHEYKRGNVAGYSKFETFPVWNVPLKHPLNIAYESATVDLKDVNMIDSFHFDAYNKVAVNYNRDIESFPVLKRIIEKITGEESVYKSPTDMGVNRVGFGIVDDEVVKEASKQEIIRRAFKTACEYKKGYVDKETFHRAKLIMEEMNLKEEDRKVVIPARKYAAKLKERANKSETCTVVALELEDGTILTGRSSELMDGTAAVILNAVKHYANISDEIHLISPVILEPIINLKVKTLGSKRTALSCEEVLIALSICAATNPTAQVAMCKLPMLKGCQAHSTTILSTNEEQTFRKLGIDVTCDPEYISESLYYNN
What are the official names of this protein?
UPF0371 protein CLB_0371.
What is the protein family that this protein belongs to?
Belongs to the UPF0371 family.