PharMolix/UniProtQA huggingface dataset:
Protein: NU4M_MAMPR
Sequence: MLKTILPTIMLIPLAWLTSNNMVWINTTLYSFAISLTSLHLLHQPLDNSLNLSPEFFLDSLSTPLLILTIWLLPLMLIASQSHLSSGSTFQKKSYITTIILLQVSLIMTFAATDLILLYIMFETTLIPTMIIITRWGNQLERLNAGSYFLFYTLVGSLPLLVTLMLIQNTLGSLNLMMLPYLAKSINNLWSTNMLWLTCIMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAILLKLGGYGMLRITILLDPLTTHMYYPFLMLSLWGMVMTSSICLRQTDMKSLIAYSSVSHMALVIIAIMLQTPWSFMGALALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLINMAPPPTINLIGELLIITTSFSWSNLTIFPMGLNVLITTMYTLHMMTTTQRGKTSHHAKSIKPSFTRENTLMTLHLLPLLLLSLNPNIIL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EFTU_AROAE
Sequence: MAKGKFERTKPHVNVGTIGHVDHGKTTLTAAITTILSKKFGGEAKAYDQIDAAPEEKARGITINTAHVEYETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLARQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSKYDFPGDDVPIIKGSALKALEGDQSDIGEPAIFRLAEALDSYIPTPERAIDRPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKATVKTTCTGVEMFRKLLDQGQAGDNVGVLLRGTKREDVERGQVLCKPGSIKPHTHFTGEVYVLSKEEGGRHTPFFNNYRPQFYFRTTDVTGSIELPEGTEMVMPGDNVSITVKLMAPIAMEEGLRFAIREGGRTVGAGVVAKIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A1KB1_LOXAP
Sequence: WIMGHMVNAIAQIDEFVNLGANSIETDVSFDSSANPEYTYHGIPCDCGRTCTKWEHFNEFLKGLRKATTPGDSKYHEKLVLVVFDLKTGSLYDNQASDAGKKLAKSLLQNYWNNGNNGGRAYIVLSIPNLAHYKLITGFKEALTSEGHPELMDKVGYDFSGNDDIGDVANAYKKAGVTGHAWQSDGITNCSLRGLDRVRKAVANRDSSNGYINKVYYWTVDKRQSTRDALDAGVDGIMTNYPDVIADVLNESAYKAKFRIASYDDNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LapSicTox-alphaIB1bi, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVD_CAUVN
Sequence: MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVANSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAIVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVTVKGKIRALDLVDAMVVAADDSYSDEEVEAIEKAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADREALFKEAGRVVVDLCQRWYEQEDATALPRGIATRAAFENAMSLDIAMGGSTNTVLHLLAAAHEGGIDFSMADIDRLSRHVPCLSKVAPAKSDVHMEDVHRAGGVMAILGELERGGLIDASQPTVHAPTMGEALARWDIGRTNSQIAHEFFKAAPGGKPTQVAFSQAARWEELDLDRENGVIRSVEHPFSKDGGLAVLFGNLAPEGCIVKTAGVDESILTFRGTARVFESQDAAVSGILGGQVKAGEVVVIRYEGPKGGPGMQEMLYPTTYLKSKGLGAACALVTDGRFSGGTSGLSIGHVSPEAGEGGLIALVETGDPILIDIPTRGITLEVSDAVLAARREAQLARGKDAWTPLNRKRDLTPALRAYAAMTTNAARGAVRDVSQIERG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: TRXF2_ARATH
Sequence: MPLSLRLAPSPTSFRYSPITSTGAGGFSPVKQHCRIPNSGVATKIGFCSGGGGVLDSGRRIGSCVVRCSLETVNVTVGQVTEVDKDTFWPIVKAAGDKIVVLDMYTQWCGPCKVIAPKYKELSEKYQDMVFLKLDCNQDNKPLAKELGIRVVPTFKILKDNKVVKEVTGAKYEDLLAAIEAARSG
What is the function of this protein?
Probable thiol-disulfide oxidoreductase involved in the redox regulation of enzymes of both reductive pentose phosphate pathway (Calvin-Benson cycle) and oxidative pentose phosphate pathway.
What are the official names of this protein?
Thioredoxin F2, chloroplastic, AtTrxf2, Thioredoxin F1, AtTrxf1.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant F-type subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: SCONB_ARTBC
Sequence: MDADNSTLPTEQSAVRETCDRDVTMSPRKRRRLSVSLEPELTEPEAAGTPGERCSTADTPESTASEPRSLFNSTPTEGNIAPFLTKHIKDQHASRNRFAPIDSSLPRRKADSKYCYRHRPDLKCRRQAVEPTVDQMQRDLSTLSQNDQQSIAHFWSLFSAAPSKHRNLMLQGIVAQCCFPQLSFLSASVRDLIRIDFVTALPPEISFKILSYLDTASLCSAAQVSHSWRALADDDVVWHRMCEQHIDRKCEKCGWGLPMLDRKRLKDTKRQVQLRAAGKEIAPNQRPQQQHRPWKAVYMDRFKVGTNWKYGRCTTTIFRGHTNGVMCLQFDDNILATGSYDATIKIWDIETGKEIRTLRGHESTIRCLQFDDTKLISGSLDRTIKVWNWRSGECISTYTGHQGGVLCLHFDSTTLASGSKDNTIKIWNFHDKSTRILRGHADWVNSVKLDTASRTVFSASDDLTVRIWDLDTGKCIHSYAGHVGQVQQVLPLPREFEFKHQSNCADDRSDRLSGSESPDHRGSHGYRSNNAPDQQPNTSAPPTEPMSPLFEALFTEDQGRPAPPRYMLTAALDLTLRLWEVHTGRCLRTFFGHIEGVWGLAADTLRFVSGAQDHMAKVWDPRTGTCERTFTGHRGPVTCVSLSDSRMATGSEDSEVRMYSFKA
What is the function of this protein?
Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
What are the official names of this protein?
Probable E3 ubiquitin ligase complex SCF subunit sconB, Sulfur controller B, Sulfur metabolite repression control protein B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MET30/SCONB/SCON-2 family.
Protein: ISPD_SALPK
Sequence: MAATLLDVCAVVPAAGFGRRMQTECPKQYLSIGNKTILEHSVHALLAHPRVTRVVIAISPGDHRFAQLPLANHPQITVVDGGNERADSVLAGLQAVAKAQWVLVHDAARPCLHQDDLARLLAISENSRVGGILASPVRDTMKRGEPGKTAIAHTVERADLWHALTPQFFPRELLHDCLTRALNEGAIITDEASALEYCGFHPALVEGRADNIKVTRPEDLALAEFYLTRTIHQEKA
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: Y1801_LISMF
Sequence: MDNGIFIVATIFIVNILYVTIYTVRLLLTMKGYRYLAALSSVFEMIIYVVALSLVLDNLNNIANVLAYAIGFGVGIIVGMKIEERIALGYITVNVITKEYNLDLPNQIRDLGYGVTSWLASGRDGERMMLEILTQRKNERKLYKHIIEIDNGAFIVSSEPKQIHGGFWVKQVRK
What are the official names of this protein?
UPF0316 protein LMOf2365_1801.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSTB_PSEPF
Sequence: MQHETHTHGINMSALGRDKQSLNLERETVAIEVPGLSLFYGEKQALYDVSMNIPKQRVTAFIGPSGCGKSTLLRTFNRMNDLVDGCRVEGAINLYGNNIYRKGEDVAELRRRVGMVFQKPNPFPKTIYENVVYGLRIQGINKKRILDEAVEWALKGAALWDEVKDRLHDSALGLSGGQQQRLVIARTIAVEPEVLLLDEPCSALDPISTLKVEELIYELKSKFTIVIVTHNMQQAARVSDYTAFMYMGKLVEFGDTDTLFTNPAKKQTEDYITGRYG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FAS1_YEAST
Sequence: MDAYSTRPLTLSHGSLEHVLLVPTASFFIASQLQEQFNKILPEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSKVGQFDQVLNLCLTEFENCYLEGNDIHALAAKLLQENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQLVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGLNILEWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQGLVTAVAIAETDSWESFFVSVRKAITVLFFIGVRCYEAYPNTSLPPSILEDSLENNEGVPSPMLSISNLTQEQVQDYVNKTNSHLPAGKQVEISLVNGAKNLVVSGPPQSLYGLNLTLRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVSFNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQEIFDVTSNGLKKNPNWLEEYHPKLIKNKSGKIFVETKFSKLIGRPPLLVPGMTPCTVSPDFVAATTNAGYTIELAGGGYFSAAGMTAAIDSVVSQIEKGSTFGINLIYVNPFMLQWGIPLIKELRSKGYPIQFLTIGAGVPSLEVASEYIETLGLKYLGLKPGSIDAISQVINIAKAHPNFPIALQWTGGRGGGHHSFEDAHTPMLQMYSKIRRHPNIMLIFGSGFGSADDTYPYLTGEWSTKFDYPPMPFDGFLFGSRVMIAKEVKTSPDAKKCIAACTGVPDDKWEQTYKKPTGGIVTVRSEMGEPIHKIATRGVMLWKEFDETIFNLPKNKLVPTLEAKRDYIISRLNADFQKPWFATVNGQARDLATMTYEEVAKRLVELMFIRSTNSWFDVTWRTFTGDFLRRVEERFTKSKTLSLIQSYSLLDKPDEAIEKVFNAYPAAREQFLNAQDIDHFLSMCQNPMQKPVPFVPVLDRRFEIFFKKDSLWQSEHLEAVVDQDVQRTCILHGPVAAQFTKVIDEPIKSIMDGIHDGHIKKLLHQYYGDDESKIPAVEYFGGESPVDVQSQVDSSSVSEDSAVFKATSSTDEESWFKALAGSEINWRHASFLCSFITQDKMFVSNPIRKVFKPSQGMVVEISNGNTSSKTVVTLSEPVQGELKPTVILKLLKENIIQMEMIENRTMDGKPVSLPLLYNFNPDNGFAPISEVMEDRNQRIKEMYWKLWIDEPFNLDFDPRDVIKGKDFEITAKEVYDFTHAVGNNCEDFVSRPDRTMLAPMDFAIVVGWRAIIKAIFPNTVDGDLLKLVHLSNGYKMIPGAKPLQVGDVVSTTAVIESVVNQPTGKIVDVVGTLSRNGKPVMEVTSSFFYRGNYTDFENTFQKTVEPVYQMHIKTSKDIAVLRSKEWFQLDDEDFDLLNKTLTFETETEVTFKNANIFSSVKCFGPIKVELPTKETVEIGIVDYEAGASHGNPVVDFLKRNGSTLEQKVNLENPIPIAVLDSYTPSTNEPYARVSGDLNPIHVSRHFASYANLPGTITHGMFSSASVRALIENWAADSVSSRVRGYTCQFVDMVLPNTALKTSIQHVGMINGRKLIKFETRNEDDVVVLTGEAEIEQPVTTFVFTGQGSQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKRIRENYSAMIFETIVDGKLKTEKIFKEINEHSTSYTFRSEKGLLSATQFTQPALTLMEKAAFEDLKSKGLIPADATFAGHSLGEYAALASLADVMSIESLVEVVFYRGMTMQVAVPRDELGRSNYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLNFIKLQKIDIIELQKSLSLEEVEGHLFEIIDEASKKSAVKPRPLKLERGFACIPLVGISVPFHSTYLMNGVKPFKSFLKKNIIKENVKVARLAGKYIPNLTAKPFQVTKEYFQDVYDLTGSEPIKEIIDNWEKYEQS
What is the function of this protein?
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH.  The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
What are the official names of this protein?
Fatty acid synthase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the fungal fatty acid synthetase subunit beta family.
Protein: MURG_OCEIH
Sequence: MKNNKRILFTGGGTAGHVIVNLALIPYYQERGWEIDYIGSYNGIERDLISPLDGVTYHSVSTGKLRRYMSKENLKDPFKVLKGTMQAYRIIGKRKPSIVFSKGGFVSVPVVAAAKLRGVPSIIHESDYTPGLANKLSIPFTKRVLATFPETMKYLPENKASYVGAVIRDELFTGKRDIGLKISGLKGNKPVLLVMGGSGGSEKINQTIRQSLTKLLDEFEIIHICGKGKVDDSIQLDGYVQFEYINHELKDIFAATDLVISRAGSNAIFEFLALRLPMLLIPLSKEASRGDQIINANSFKKKNYARVLQEEELTEQSLESHLLELSKAAPIIRDEMKKYKSEQSLQSVTEIIDNVMK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: C1TC_HUMAN
Sequence: MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
What is the function of this protein?
Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:1881876, PubMed:10828945, PubMed:18767138).  These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:25633902, PubMed:18767138).
What are the official names of this protein?
C-1-tetrahydrofolate synthase, cytoplasmic, C1-THF synthase, Epididymis secretory sperm binding protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_SPHAL
Sequence: MPFYEHVFIARQDLSQAQVDALAETVTGVIGEYKGQVHKTETWGLKQLAYKIQKNRKGHYVMLSAEVSGEAIAEIERQAAINEDIIRWMTIKVDELEKGPSVMMRKQERRGGRGGRDRDGEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PUR9_STUS1
Sequence: MTDQTTRLPVRRALISVSDKTGVVDFARELEALGVEILSTGGTFKLLRENGIAAIEVADYTGFPEMMDGRVKTLHPKIHGGILGRRDLDGAVMAEHGIAPIDLVAVNLYPFAATVAKPGCTLPDAIENIDIGGPTMVRSAAKNHKDVAIVVNAEDYAAVVDNLKNGGLTYAQRFDLALKAFEHTAGYDGMIANYLGGIDQSTEQLSTDNRSLFPRTYNMQFIKAQDMRYGENPHQQAAFYVEKPDEACVATARQLQGKELSFNNVADTDAALECVKSFTKPACVIVKHANPCGVAVVPENEGGIRKAYDLAYATDSESAFGGIIAFNRELDGETAQAIVERQFVEVIIAPKVSQAARDVVASKANVRLLECGEWPAERSPGWDYKRVNGGLLIQSRDIGMITEADLKIVTQRAPTEQEIHDLIFAWKVAKFVKSNAIVYAKNRQTVGVGAGQMSRVNSARIAAIKAEHAGLQVQGAVMASDAFFPFRDGIDNAAKAGITAVIQPGGSMRDNEVIAAADEAGIAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: RNPH_CLOPS
Sequence: MRSSGRKKEQIRPVKITRNFTKYAEGSVLIEVGDTKVLCTASIEEKVPPFLKGSGEGWITAEYNMIPRSTQSRKQRDINKLKIDGRTMEIQRLIGRALRSAVDMKALGEKTIWIDCDVLQADGGTRTTSITGSFVALVDAVNKLHQKKPFNVYPIRHFVSAVSIGIVGEEKVLDLCYEEDHVAKVDMNVVMIEEGEFIEIQGTGEIGPFSRKELDELLNLAEKGAKQMIQAQKNALKTDSLWIGTGRE
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: TRUB_PSET1
Sequence: MAKRSKGRPVDGILLLNKPIGISSNKALQQTKGVYFAQKAGHTGALDPLATGMLPICFGEATKFTQFLLDTDKTYVVRAKLGERTTTSDSDGEIVSTKDVNVTREQLIKEIAAFVGESDQYPSMYSALKYQGRPLYKYAREGIEVPRKCRKINVFSLTFDEFDEVNNVIQMTAHVSKGTYIRTIVDDLGEKLGCGAHVVMLHRTAVGQYPAEKMVSLDEIEALLAKAKDEEVAPSTYLDALLLPLDTALVDLPVVEISKEQGSIFSHGQAIDLDIDLPEGAIKVVADGIFIGTGERNASGHLKVKRGLASQQDDYVKPE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: DCTA2_PSEAE
Sequence: MTKQPFYKSLYVQVLVAIAIGIALGHWYPETAVAMKPFGDGFVKLIKMAIAPIIFCTVVTGIAGMQSMKSVGKTGGMALLYFEVVSTVALIIGLVVVNVVQPGAGMHVDPNTLDTSKIAAYAAAGEKQSTVDFLMNVIPGTVVGAFANGDILQVLFFSVLFGYALHRLGSYGKPVFEFIERVSHVMFNIINVIMKVAPIGAFGAMAFTIGAYGVGSLVQLGQLMLCFYITCILFVLIVLGGIARAHGFSILRFIRYIREELLIVLGTSSSESALPRMIDKMEKLGCNKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATDTPMDITHQITLLLVLLIASKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATVVVSKWCKQLDEGTLQRELAGEGNASSPASDIPVGGREAV
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein 2.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROE_SALPK
Sequence: MEIYAVFGNPIAHSKSPFIHQQFAQQLDIVHPYGRVLAPINNFINTLDAFFAAGGKGANITVPFKEEAFARSDELTERASLAGAVNTLKRLEDGRLLGDNTDGIGLLSDLERLNFIRPGLRILLIGAGGASRGVLLPLLSLDCAVTITNRTASRAEALAKIFAHTGSVHATDMDKLDGCEFDLIINATSSGIRGEIPAIPASLIHPSLCCYDMFYQKGNTPFLSWCVQQGAKRYADGLGMLVGQAAHAVLLWHGVLPQVEPVIELLQQELLA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: Y042_MYCPN
Sequence: MKKLHKILLGLSLPASLAPLSGFISTDADNSQFSLKKSSTEIKGTQSIHLLNLGESLTEEIKEAQKRTPETSFASFKQKFPNKESFVKGFQPIDVYNLLSGWKDAISSFLDKVVELQKKIEEANKIFNTNIGNQIDLPEDENPNVLNVLGSYGGEGFFPTLGKNGLNLPQQIFENFTDFKVVSHKIHDFQVSLVGERDIIKNDKVRFSYAVQIPLNLELLVNNQKVTFNITVDLRTNNFSTQETFNELFNKCIGPVNWQFFSRVKVDKLHYDQTDATHLANTLLQDQFNALNLDLEKSIYDLELPRLEAEFQQKYVDPLIEKKQRQKAEWEEAERIRKEEEEKHQKELEEQQRIQAEKAKNDEQLQKPQTELKKALGGIDSFVEFFTNNDLRLKLGYTKEDNVRTRAGLFRALEVSFGNYRAWTFYITLLGWKDTTEKIFKKAKWQDIRDDEKFRKAFGLSPKATEKDVGKVTNPGYGYQGIYIKDSLRDGIAKYSDSTVSEPKNVKVSLPGTVGDNEEGKIWIASHNFRQNHEWGAGEKFKYSAYRFKFDVTVDYDVEVSAKWWTWAFRGSIPGYWRGKFKVTYSFDGVVPSWKYGHIQVRTPQYSFNKQEQKILFVPHAIQKIAAEGSNLDLINPFLKDQKLDEFEHYHPDLTKPLDLVAYLLYAITTRS
What are the official names of this protein?
Uncharacterized protein MPN_042.
What is the protein family that this protein belongs to?
Belongs to the MG032/MG096/MG288 family.
Protein: TRXB_ECOLI
Sequence: MGTTKHSKLLILGSGPAGYTAAVYAARANLQPVLITGMEKGGQLTTTTEVENWPGDPNDLTGPLLMERMHEHATKFETEIIFDHINKVDLQNRPFRLNGDNGEYTCDALIIATGASARYLGLPSEEAFKGRGVSACATCDGFFYRNQKVAVIGGGNTAVEEALYLSNIASEVHLIHRRDGFRAEKILIKRLMDKVENGNIILHTNRTLEEVTGDQMGVTGVRLRDTQNSDNIESLDVAGLFVAIGHSPNTAIFEGQLELENGYIKVQSGIHGNATQTSIPGVFAAGDVMDHIYRQAITSAGTGCMAALDAERYLDGLADAK
What are the official names of this protein?
Thioredoxin reductase, TRXR.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IAPP_SHEEP
Sequence: GTATCETQRLANFLAPSSNKLGAIFSPTKMGS
What is the function of this protein?
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
What are the official names of this protein?
Islet amyloid polypeptide, Amylin.
What is the protein family that this protein belongs to?
Belongs to the calcitonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NEK7_RAT
Sequence: MDEQPQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVYDVAKRMHACTASS
What is the function of this protein?
Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946).  Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (By similarity).  Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity).  Phosphorylates RPS6KB1 (PubMed:11516946).  Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (By similarity).  Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (By similarity).  Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase Nek7, Never in mitosis A-related kinase 7, NimA-related protein kinase 7.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (By similarity). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity).
Protein: Y2508_LACPL
Sequence: MKAIITVVGQDQVGIVAKVANELARLKINIVDISQTLMDHNFTMMLSAEWDDQQLSFAAAKAALESLGEASELTIRIQRQAVFDAIQKL
What are the official names of this protein?
UPF0237 protein lp_2508.
What is the protein family that this protein belongs to?
Belongs to the UPF0237 family.
Protein: TPRA1_MOUSE
Sequence: MASLQEANGSTAWPPPTASNISEPHQCLLLLYEDIGSSRVRYWDLLLLIPNVLFFIFLLWKLPLARAKIRVTSSPIFITFYILVFVVALVGIARAVVSMTVSASDAATVADKILWEITRFFLLAIELSVIILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDSHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVILPKTPLKERVSLPSRRSFYVYAGILATLNLLQGLGSALLCANIIVGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDEAEEPDMHLPQPYAVARREGIESAGPACASAANYSSTQFDSAGVAYLDDIASMPCHTGSINSTDSERWKAINA
What are the official names of this protein?
Transmembrane protein adipocyte-associated 1, Integral membrane protein GPR175, TPRA40, Transmembrane domain protein of 40 kDa regulated in adipocytes.
What is the protein family that this protein belongs to?
Belongs to the UPF0359 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.