PharMolix/UniProtQA huggingface dataset:
Protein: IDLP_ECOLI
Sequence: MENEHQYSGARCSGQAAYVAKRQECAK
What is the function of this protein?
A short protein whose stop codon overlaps with the start codon of downstream iraD; its mRNA secondary structure is predicted to fold and sequester the Shine-Dalgarno sequence of iraD.  When this protein is expressed the downstream iraD is also expressed due to ribosomal coupling (PubMed:28851853).
What are the official names of this protein?
iraD leader peptide.
Protein: U1SBP_MOUSE
Sequence: MSDWMPIAKEYDPLKAGSIDGTDEDPHDRAVWRAMLARYVPNKGVTGDPLLTLFVARLNLQTKEEKLKEVFSRYGDIRRLRLVRDLVTGFSKGYAFIEYKEERALMKAYRDADGLVIDQHEIFVDYELERTLRGWIPRRLGGGLGGKKESGQLRFGGRDRPFRKPINLPVVKNEPHREGKRERRERSRSRDRHWDPRPRERDHDRGREKHWQERARVWPENDWEREREFREERVKSRDKRDRSK
What are the official names of this protein?
U11/U12 small nuclear ribonucleoprotein 35 kDa protein, U11/U12 snRNP 35 kDa protein, U1 snRNP-binding protein homolog.
What are the subcellular locations of this protein?
Nucleus.
Protein: YO293_YEAST
Sequence: MKLLFLNIIVVRRHLHCKSYRLSPWYIYIYGDYLLYTTEIPYKPFTRQP
What are the official names of this protein?
Uncharacterized protein YOR293C-A.
Protein: YCF12_NOSP7
Sequence: MFDAVSDLVNAFTSINWEVIFQLLSVALIVIAGPVVIFLLAFRNGNL
What is the function of this protein?
A core subunit of photosystem II (PSII).
What are the official names of this protein?
Photosystem II reaction center protein Ycf12.
What is the protein family that this protein belongs to?
Belongs to the Ycf12 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: LEPA_YERPE
Sequence: MKHIRNFSIIAHIDHGKSTLSDRIIQICGGLSEREMAAQVLDSMDLERERGITIKAQSVTLDYHSKDGQTYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAIRCSAKTGVGVPDVLERLVRDIPAPEGDPNGPLQALIIDSWFDNYLGVVSLIRIKNGSLRKGDKVKVMSTGQSYNADRLGIFTPKRVDRDVLNCGEVGWLVCAIKDILGAPVGDTLTLTRNPAEKSLPGFKKVKPQVYAGLFPISSDDYESFRDALGKLSLNDASLFYEPESSTALGFGFRCGFLGLLHMEIIQERLEREYDLELITTAPTVVYEVITTNQETVYVDSPSKLPALNNIEELREPIAECHMLLPQEYLGNVITLCIEKRGTQTNMVYHGKQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQTSDMVRVDVLINNERVDALALITHRDNAQYRGRDLVEKMKELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSRKKKLLQKQKDGKKRMKQVGNVELPQEAFLAILHVGKDSK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TX1_CERDA
Sequence: DCLGWFKSCDPKNDKCCKNYSCSRRDRWCKYDL
What is the function of this protein?
Potent inhibitor of hNav1. 7/SCN9A (IC(50)=16 nM, tested in patch-clamp), and modest inhibitor of Cav2. 2/CACNA1B (IC(50)~3 uM on rat and human channel) (PubMed:28880874).  It seems also to be potent on hNav1. 1/SCN1A (IC(50)=2. 18 uM), hNav1. 2/SCN2A (IC(50)=0. 13 uM), hNav1. 7/SCN9A (IC(50)=3. 34 uM) and hNav1. 8/SCN10A (IC(50)=6. 92 uM) (tested in fluorimetric assays, which shows results with lower activity than results obtained by patch-clamp) (PubMed:28880874).  This toxin inhibits Cav2. 2/CACNA1B by acting near the pore region, but without overlapping the omega-conotoxin binding site (PubMed:28880874).  It also seems to interfere with inactivation of Cav2. 2/CACNA1B with no apparent effects on the activation gating of the channel (PubMed:28880874).  Conversely, at Nav1. 7/SCN9A it acts as a typical gating modifier toxin, interacting with one or more of the voltage sensor domains and changing the gating properties of this channel (PubMed:28880874).  In vivo, it reversibly paralyzes sheep blowflies (PubMed:28880874).  In addition, low doses of this toxin (400 pmol) fully reverse Nav1. 7/SCN9A-evoked pain behaviors in mice (without side effects), demonstrating its analgesic potential (PubMed:28880874).
What are the official names of this protein?
Beta-theraphotoxin-Cd1a, Beta-TRTX-Cd1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 04 (CcoTx1) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DGTL1_COREF
Sequence: MYPYSESDAQRLHQEAPKASQLAHSEVDLRSDFSRDRARVLHSAALRRLADKTQVVGPRDGDTPRTRLTHSLEVAQIARGMGSGLGLDPELSELAGLCHDIGHPPYGHNGEKALNEVAAACGGFEGNAQTLRILTRLEPKVVSADGTSFGLNLTRAALDAACKYPWTKTSPDGTINRKYGAYDEDAHILEWVRRGHTDLRPSLEAQTMDFSDDIAYSVHDVEDGIVAGRIDLKVLWDLVELAALAQKGARAFGGDPEELIEGAATLRELPVVAAAADFDASLSSYAALKAMTSELVGRYVGSTIAATRAAARLGEYEFGRMHGELVIRPEADREVRLLKTLAVLYVMDDPGHLARQDRQRDRIFRVFDYLTLGAPGSLDPMYRQWFLEADDDAGRARVVVDQIASMTESRLERLARNASGISGFLG
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: Y1658_STRP6
Sequence: MTFTIMTDSTADLNQTWAEDHDIVLIGLTILCDGEVYETVGPNRISSDYLLKKMKAGSHPQTSQINVGEFEKVFREHARNNKALLYLAFSSVLSGTYQSALMARDLVREDYPDAVIEIVDTLAAAGGEGYLTILAAEARDSGKNLLETKDIVEAVIPRLRTYFLVDDLFHLMRGGRLSKGSAFLGSLASIKPLLWIDEEGKLVPIAKIRGRQKAIKEMVAQVEKDIADSTVIVSYTSDQGSAEKLREELLAHENISDVLMMPLGPVISAHVGPNTLAVFVIGQNSR
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein M6_Spy1658.
Protein: 143G2_ONCMY
Sequence: MVDREQLVQKARLAEQAERYDDMAAAMKSVTELNEALSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLNLLDNYLIKNCNETQHESKVFYLKMKGDYYRYLAEVATGEKRATVIESSEKAYNEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYQDSTLIMQLLRDNLTLWTSDQQDDEGGEGNKD
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner (By similarity).
What are the official names of this protein?
14-3-3 protein gamma-2, Protein 14-3-3G2.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_BACLD
Sequence: MRKAERARKTNETDIKLSFHIDGEGKADIQTDVPFMTHMLDLFTKHGQFDLSIEAKGDVEIDDHHTTEDIGICLGQALLEALGDKQGIKRYGSSMVPMDEALAQVAIDLSNRPHLEFRAEFPSRKIGTFDTELVHEFLWKFALEARMNLHVIVHYGTNTHHMIEAIFKALGRALDEAALIDPRVKGIPSTKGML
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABRAL_DANRE
Sequence: MNVEHEVSLLIDEIRRLGSKNADGKTSVKFGVLFNDDQCANLFEALVGTLKAAKRKKVITFDGELLLQGVHDNVDVVLLQD
What are the official names of this protein?
Costars family protein ABRACL, ABRA C-terminal-like protein.
What is the protein family that this protein belongs to?
Belongs to the costars family.
Protein: H2AJ_HUMAN
Sequence: MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESQKTKSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.J, H2a/j.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: FADA_SHIDS
Sequence: MEQVVIVDAIRTPMGRSKGGAFRNVRAEDLSAHLMRSLLARNPALEAAALDDIYWGCVQQTLEQGFNIARNAALLAEVPHSVPAVTVNRLCGSSMQALHDAARMIMTGDAQACLVGGVEHMGHVPMSHGVDFHPGLSRNVAKAAGMMGLTAEMLARMHGISREMQDAFAARSHARAWAATQSAAFKNEIIPTGGHDADGVLKQFNYDEVIRPETTVEALATLRPAFDPVNGTVTAGTSSALSDGAAAMLVMSESRAHELGLKPRARVRSMAVVGCDPSIMGYGPVPASKLALKKAGLSVSDIGVFEMNEAFAAQILPCIKDLGLIEQIDEKINLNGGAIALGHPLGCSGARISTTLLNLMEHKDVQFGLATMCIGLGQGIATVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYTL4_RAT
Sequence: MSEILDLSFLSEMERDLILSVLQRDEELRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLISKSNTCVGCNHLVCRECRVLESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFAYRTGSDIIRMSLRRKPAVNKRETVGQSLLQQTQMGDIWPGRRIIQEQQKEQSVLFEVPKLKSGKSALEAESESLDSYTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKEIAPGNQNAVCGDEGDMIFKKNTRKVLRPSEYTKSVIDLRPEDVAQESGILGDRSKSVPGLSVDMEDEEEEEEDIDHLVKLHRQKLARGSMQSGSSMSTIGSMMSLYSEAGDFGNVSVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISSGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMVKQKLGV
What is the function of this protein?
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary.  Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).
What are the official names of this protein?
Synaptotagmin-like protein 4, Exophilin-2, Granuphilin.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.
Protein: GCH3_METS3
Sequence: MIQMTLIQIDNYGPWTVTPRPRNESDLQILQAELYADLERQFANKKGLVFFTRFDNLLAVTNGIDEEDHLRIQRSIRNRYPITISMGVGAAETPHEAQKLATIALQKEGGAQSSKRKEILAIDSLAPADENNLVQAAHIDINSVTETLTDIESAFDTNFMVNKAQHYLMTKLIKKGALLFFIGGDNFMAPCNGLSEKEIEDILVEINDEIGIGLKAGIGVGRNMEDAAYMADLGLEEIRDHDNGMWTWVIEKEY
What is the function of this protein?
Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP.  Also has an independent pyrophosphate phosphohydrolase activity.
What are the official names of this protein?
GTP cyclohydrolase III.
What is the protein family that this protein belongs to?
Belongs to the archaeal-type GTP cyclohydrolase family.
Protein: NUCG_BOVIN
Sequence: MQLLRAGLTLALGAGLGAAAESWWRQRADARATPGLLSRLPVLPVAAAAGLPAVPGAPAGGGPGELAKYGLPGVAQLKSRASYVLCYDPRTRGALWVVEQLRPEGLRGDGNRSSCDFHEDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLEKYSRSLTRTYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIELRSYVMPNAPVDEAIPLEHFLVPIESIERASGLLFVPNILARAGSLKAITAGSK
What is the function of this protein?
Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (By similarity).  The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity).  Shows significantly higher affinity for four- stranded Holliday junction over duplex and single-stranded DNAs (By similarity).  Promotes conservative recombination when the DNA is 5hmC-modified (By similarity).  Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (By similarity).  GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (By similarity).  Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (By similarity).
What are the official names of this protein?
Endonuclease G, mitochondrial, Endo G.
What is the protein family that this protein belongs to?
Belongs to the DNA/RNA non-specific endonuclease family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YMGG_ECOL6
Sequence: MKKKILAFGLISALFCSTPAMADMNRTTKGALLGAGVGLLTGNGVNGVLKGAAVGAGVGAVTEKGRDGKNARKGAKVGAAVGAVTGVLTGNGLEGAIKGAVIGGTGGAILGKMK
What are the official names of this protein?
UPF0757 protein YmgG.
What is the protein family that this protein belongs to?
Belongs to the UPF0757 family.
Protein: RUVB_CLOPS
Sequence: MSERLVTSNEIGIDSTNEYSLRPEKINEYIGQDKVKERLNIFIKAAQRRGEALDHVILYGPPGLGKTTLANIIANEMGGNLKITSGPAIERAGDLAAILTTLNTNDVLFIDEIHRLNRSVEEILYPAMEDYVLDIIIGKGAASKSIRLDLPKFTLIGATTRIGMLSSPLRDRFGVLCSMEYYTDEQLKEIIIRSAEILGCHITEEGAFEIAKRSRGTPRIANRLLKRVRDFAEVLYDNEITEEAAKKSLEILEVDGEGFDRIDNKILEAIIDNFNGGPVGIETLAYFVGEELDTIEDVYEPYLLQKGFIVRTPRGRMATDKAYKHLGRVRFNESKIDSKQCTLFEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: Y2594_HALH5
Sequence: MLTSNRQGMAVYLTSLKFARQLRRFGYVHYVSKKMRYVVLYCNEEAVQTTMEKLQSFHFVKDVQLSMRPYVQTEFQNAKPDKAKEYDYKMGL
What are the official names of this protein?
UPF0298 protein BH2594.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
Protein: MIAA_BURP0
Sequence: MSERNAASARTVACLLGPTASGKTAAALALAARRPIEIVSVDSALVYRGMDIGTAKPTRDERAAVPHHLIDIVDPADAYSAAEFRADALRLVAQIAARGRTPLLAGGTMLYYRALTQGLNDLPAADPDVRATLDADAARDGWPALHARLAGIDPATAARLAPNDSQRIQRALEVYLLTGQPMSALLAAPPRDDDAAAGLRFVPVALEPSERAVLHARIAARFDAMLEAGFIDEVERLRRRDDLHLGLPSMRCVGYRQAWEYLDGCTDYRTMRDKGIFATRQLCKRQLTWLRAMPERIVVDCCAPDATVRAVDALERVLDGRAPA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: FLRT1_MOUSE
Sequence: MDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQDLKTKVKVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVRARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFEAGSQGGAANAAAKTTVSNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLVIQVKPLTADSIRITWKAMLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMVTMETGNTYVADETPVCAKAETADSYGPTTTLNQEQNAGPMAGLPLAGIIGGAVALVFLFLVLGAICWYVHRAGELLTRERVYNRGSRRKDDYMESGTKKDNSILEIRGPGLQMLPINPYRSKEEYVVHTIFPSNGSSLCKGAHTIGYGTTRGYREAGIPDVDYSYT
What is the function of this protein?
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases (PubMed:16872596, PubMed:20421966).  Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases.  Promotes an increase both in neurite number and in neurite length (PubMed:20421966).  May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3 (PubMed:22405201).
What are the official names of this protein?
Leucine-rich repeat transmembrane protein FLRT1, Fibronectin leucine rich transmembrane protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cytoplasmic vesicle membrane. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Secreted. Cell projection, neuron projection. Cell junction. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles (PubMed:16872596, PubMed:20421966). Detected along neurites and at contacts between neurite termini and other cells (PubMed:20421966). Proteolytic cleavage gives rise to a shedded ectodomain (PubMed:21673655).
Protein: HFQ_YEREN
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQVESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNPSGSTNNYHGSNPSAPQQPQQDSDDAE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs (By similarity).  Positively regulates the expression of the yst gene for heat-stable enterotoxin (Y-ST).
What are the official names of this protein?
RNA-binding protein Hfq, Yersinia multiple regulator, Yersinia regulator for pleiotropic phenotype.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: CPAH_ASPOZ
Sequence: MSQFAREIVRNAIYNTSSPDADSVSLRKATTTILLIGVTYCILVGIYRVTLHPLAKYPGPKLAAVTRLWHSYHLCTGDIVSVLSRAHEAYGPVLRIAPDEVLFISSRAWDDIYGARPGKPEMDKDTPLYKGPTAPHSIVTVDGELHRFYRRLLAKGFSDAALREQEPVIQRNINLLVEKLHKEVAAGKTPEMTAWFNYATFDLIGELAFGETYGCLENSHYHPWVEMILEVMKLRAMTHAVGYYPWIFHILMWFVPKSLREKFVTHRRYTHDKVQRRMDQKIHYKDLTTNLVDPQNGLERYEIDGNCSTLIIAGSETTATALSATLYFLTQNENAKRKVIGEIRTTFNNAGDINSISVNQLKYLSACMNEALRIFPPGPAVFPRRVPQGGDFIDGHWIPGGTQVGIAHYCINRSRRNFVDPDKFIPERWLGDPTYQTDDRHAVQPFSYGPRNCIAHNLARLEMRLVLARLIWEFDWELAPGSERWEEEALVFNVWSTKPLMIKFTPVAR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the fungal neurotoxin cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca(2+)-ATPase with a unique pentacyclic indole tetramic acid scaffold (PubMed:21608094).  The hybrid two module polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) cpaS incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-terminal redox-incompetent reductase domain to make and release the tryptophan tetramic acid, cyclo-acetoacetyl-L-tryptophan (c-AATrp), as the first intermediate in the pathway.  CpaS catalyzes a Dieckmann-type cyclization on the N-acetoacetyl-Trp intermediate bound in thioester linkage to the phosphopantetheinyl arm of the T domain to form and release c-AATrp (PubMed:21608094, PubMed:19663400).  CpaD then regiospecifically dimethylallylates c-AATrp to form beta-cyclopiazonic acid.  CpaD discriminates against free Trp but accepts tryptophan-containing thiohydantoins, diketopiperazines, and linear peptides as substrates for C4-prenylation and also acts as regiospecific O-dimethylallyltransferase (DMAT) on a tyrosine-derived tetramic acid (PubMed:21608094, PubMed:19877600).  The beta-cyclopiazonate dehydrogenase cpaO then carries out the dehydrogenation of beta-CPA to yield an unstable enimine product, which is captured by intramolecular cyclization to create the pentacyclic fused scaffold of alpha-cyclopiazonate (PubMed:21608094).  Finally, the cytochrome P450 monooxygenase cpaH mediates the conversion of CPA into the less toxic 2-oxocyclopiazonic acid, the end product of the CPA pathway in A. oryza (PubMed:21608094).
What are the official names of this protein?
Cytochrome P450 monooxygenase cpaH, Cyclopiazonic acid biosynthesis cluster protein H.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ASTE_SHEB9
Sequence: MLQALLDSKDFLALTLAHPEQFDSEFSFRLGDHTQVEVWDTGVIVFEPAQNEGKDVVLSCGVHGNETAPIELCNGLIKQLLQQKIIAKQRTLFLIGNPLAINNGTRIIDENMNRLFSGEHSNPPGLVNPERVRAKKLEAYIDRFYTAVADGRQRIHYDLHTAMRASKHEKFAIYPYRPGRAFSGEQIMFLAASGVDTVLFHHEPTTTFSYFSSERYGADAFTIELGKVYPMGQNDMTRFIATHEMFMRLITAKPLELDAFDADKVNLYQVCRVINKHFDDFEFTFATDVENFRSFPKGFVLAREGGQEIKVEHEFESVVFPNAKVPIGNRTVICLIPAVNADVR
What is the function of this protein?
Transforms N(2)-succinylglutamate into succinate and glutamate.
What are the official names of this protein?
Succinylglutamate desuccinylase.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
Protein: ATG27_CANGA
Sequence: MVMLGQVVALAMASSAVALNCKNHNVLSNYNVANKDILLKNELDTPPSKTSEMWYLAPCEDGSRRQRPSECSSDDLMCAIRHVKVDGSDHLTQKLDVHKSAKYEVEEVESGGFDIRFLGVKWGSNTIDATLSYSCDTNLKTDELVTTIWNSEYVLIEMSGPSGCKRDGNSDSGDNGNGNGNGNDPDNNNNTGKDKKSKKTSWFTWLFVYAILFTVIYLMVVSYLNTKGGSFQDFRNEFVERGTEFITSLPTFVKEVVTKTLGTRDSSASRGGYSAV
What is the function of this protein?
Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling.  Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation.  Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity).
What are the official names of this protein?
Autophagy-related protein 27.
What is the protein family that this protein belongs to?
Belongs to the ATG27 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Mitochondrion membrane; Single-pass membrane protein. Preautophagosomal structure membrane; Single-pass type I membrane protein. Note=Cycles among the pre-autophagosomal structure (PAS), mitochondria and Golgi.