PharMolix/UniProtQA huggingface dataset:
Protein: ATPB_STRZP
Sequence: MSSGKIAQVIGPVVDVLFAAGEKLPEINNALVVYKNDERKTKIVLEVALELGDGMVRTIAMESTDGLTRGMEVLDTGRPISVPVGKETLGRVFNVLGDTIDLEAPFTEDAERQPIHKKAPTFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLVQLGIYPAVDPLASSSRALAPEIVGEEHYAVAAEVKRVLQRYHELQDIIAILGMDELSDEEKTLVARARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILDGKYDHLPEDAFRGVGSIEDVIAKAEKMGF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CEP44_XENTR
Sequence: MATGDVKGCIRKLEQRLRTLNYPRDVDYSGLIKGDPSAFLPIISYTFTCYSTSIAEILISLGIELATKSDLRFIEAVYKVLRDVFNYKPILTKQQFLQCAFSERKIQIICDIVDCVVKKHKEITGQNKIKNQPVKKIVSAKDQCEVFYPEDMFVQLSVKTEMSTQKKPLVERHTGSEFQLQTKCYKSALLEEAEEEEPTSDCEEDSHLQREMGSPFETAEETPNSEQVELLRKQLAECQEKLQRLDCVEERLQSLETSVKGKIIIDETDWNNLLGRVLLLETERLLQSKKSDLPEFARISEHRTSSRMANEICSNLKTKADIPESHHQSSGYSSVLSADTSPIAIDINYSSLTEESKETTKQRMERITKMMEETSELLKFSNNTS
What is the function of this protein?
Centriole-enriched microtubule-binding protein involved in centriole biogenesis.  In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall.  Functions as a linker component that maintains centrosome cohesion.  Associates with CROCC and regulates its stability and localization to the centrosome.
What are the official names of this protein?
Centrosomal protein of 44 kDa, Cep44.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Localizes to the proximal end of mother and daughter centrioles.
Protein: FLIT_LYSSC
Sequence: MYQTDQLLQVSANLFKHLGDIPNGEERDEYIETINTMLDKRETIIKGLKQEGFQFDEQNRIHRTLLELDKGIKQRLAAVMDAVKQDMANLQKTKKSEQQYFNPYSNVRVMDGMYYDKKN
What is the function of this protein?
May act as an export chaperone for the filament capping protein FliD.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the bacillales FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PPNN_SHIFL
Sequence: MITHISPLGSMDMLSQLEVDMLKRTASSDLYQLFRNCSLAVLNSGSLTDNSKELLSRFENFDINVLRRERGVKLELINPPEEAFVDGRIIRALQANLFAVLRDILFVYGQIHNTVRFPNLNLDNSVHITNLVFSILRNARALHVGEAPNMVVCWGGHSINENEYLYARRVGNQLGLRELNICTGCGPGAMEAPMKGAAVGHAQQRYKDSRFIGMTEPSIIAAEPPNPLVNELIIMPDIEKRLEAFVRIAHGIIIFPGGVGTAEELLYLLGILMNPANKDQVLPLILTGPKESADYFRVLDEFVVHTLGENARRHYRIIIDDAAEVARQMKKSMPLVKENRRDTGDAYSFNWSMRIAPDLQMPFEPSHENMANLKLYPDQPVEVLAADLRRAFSGIVAGNVKEVGIRAIEEFGPYKINGDKEIMRRMDDLLQGFVAQHRMKLPGSAYIPCYEICT
What is the function of this protein?
Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base.  Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates.  Cannot catalyze the reverse reactions.  May contribute to nucleoside pool homeostasis by degrading excess nucleotides and feeding back the ribose moiety to catabolism.
What are the official names of this protein?
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase, AMP nucleosidase, CMP nucleosidase, GMP nucleosidase, IMP nucleosidase, UMP nucleosidase, dTMP nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the LOG family.
Protein: THRC_HELPJ
Sequence: MPFVPTRSLKERKIDFIEAVLNPNAPKGGLYTLEHFETLEWQDCLGMSYSELVEHVFELLNLEIPKNLLASALKRYENFDNPKNPAPIFALNERLFVQELYHGPSLAFKDMALQPLASLFSNLAVGKNEKYLVLVSTSGDTGPATLEGLAGMPNVFVVCLYPKDGTSLVQKLQMVTQNASNLKVFGVSGDFDDAQNALKNLLKDDDFNEALKARQLKLSVANSVNFGRIAFQIVYHIWGFLELYKKGAINSKEKITLAIPSGNFGNALGAFYAKKMGLNIAKIKVVTNSNDVLREFIETGRYDLTKRSLKQTFSPAMDILKSSNVERALFSLFGFERTLELMQALEEEKFYALKPKELALLQEHFSCASCSDEDCLKTIQEVYAEHQYLIDPHTATALNASLKTHEKTLVSATASYEKFPKTTLLALNEQKKNDDDKAALETLKNSYNTPDSQRLDDLFERGIKHQEVLKLNEIKSSILLWLENTH
What is the function of this protein?
Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.
What are the official names of this protein?
Threonine synthase, TS.
What is the protein family that this protein belongs to?
Belongs to the threonine synthase family.
Protein: DYR_SHV2C
Sequence: MVLLLNCIVAVDQNMGIGKKGHLPWPLLINDFKYFQRMTTSSVKNKQNLVIMGKNTWFSIPEKNRPLKDRINLVLSKKLKEIPHGAHFLARSLNDALKLIEQPELVNKVDRVWIIGGSSVYKDAMNYSSHLKLFVTRIMQSFETDTFFPEIDLKNYKLLIEYPGVPSNTQEEKGIKYKFEVYEKIVNTFLFKSHAGLTCSVKPKEASYDFELS
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Viral dihydrofolate reductase, vDHFR.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: CLD5_RAT
Sequence: MGSAALEILGLVLCLVGWVGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYESVLALSAEVQAARALTVGAVLLALVALFVTLTGAQCTTCVAPGPVKARVALTGGALYALCGLLALVPLCWFANIVVREFYDPTVPVSQKYELGAALYIGWAASALLMCGGGLVCCGAWVCTGRPEFSFPVKYSAPRRTTANGDYDKKNYV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space.
What are the official names of this protein?
Claudin-5.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: MNME_NEIMB
Sequence: MSDNVPTIAAVATAPGRGGVGVIRISGKNLLPMAQALCGKTPKPRTATYADFTDTDGQAIDSGLLLFFAAPASFTGEDVIELQGHGGPVVMDMLLNRCLELGARLAEPGEFTKRAFLNDKLDLAQAEGVADLIDASSRSAARLALRSLKGDFSRRIHGLVEDLITLRMLVEATLDFPEEDIDFLEAADARGKLDGLRRAVDDVLANAQQGAILREGLNVVLVGAPNVGKSSLLNALAGDEVAIVTDIAGTTRDAVRERILIDGVPVHIVDTAGLRETDDVVERIGIERSRKAVSEADVALVLVDPREGLNEKTRAILDALPPELKRIEIHSKSDLHAHAAGGFGTGAETVIALSAKTGDGLDALKRTLLREAGWQGESEGLFLARTRHVNALKAAQEELSLAALCGNHQIELFAEHLRLAQVACGEITGEFTADDLLGVIFSRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_SHISS
Sequence: MAPPLSPGSRVLIALIRVYQRLISPLLGPHCRFTPTCSSYGIEALRRFGVIKGSWLTVKRVLKCHPLHPGGDDPVPPGPFDTREH
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PRAM6_HUMAN
Sequence: MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAMARGCFLNAKRNKTPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAPRESYDADGTLCWSRFAQIRAELMKRVRDLRHPKRILFCTDCCPDCGNRSFYDLEADQCCC
What is the function of this protein?
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:26138980).  The CRL2(PRAMEF6) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980).
What are the official names of this protein?
PRAME family member 6.
What is the protein family that this protein belongs to?
Belongs to the PRAME family.
Protein: RL15A_YEAST
Sequence: MGAYKYLEELQRKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRATAEERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWICDPVHKHREARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWRYRK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L15-A, L13, Large ribosomal subunit protein eL15-A, RP15R, YL10, YP18.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNA3_DICDI
Sequence: MSNRRREFIEYIDSREPVEADIDISDKADRLTDIYDSDTYGLNAMRETLPSHCYKKIREVMQTGSALDPEIADMVANGMKEWAIKQGATHYCHWFLPLNGLAAEKHDSFISIFPGDDKVLLEFSGMQLIKGEPDASSFPSGGIRSTWEARGYTVWDATSPAFIRREKNGAILCIPTAFCSWTGEALDQKTPLLRSMEYVSNESIITLSSLFNEKHKRISPTLGIEQEFFLIDRKFYLARPDLVNCGRTLIGAKPPKGQEMEDHYFGTMNSRIISCIQEVEWKMWRLGMPLKTRHNEVAPGQYEVAPIFERANIAADHNMMLMDILKNVSTKHGLVCLFHEKPFAGVNGSGKHNNWSLSTDGGSNLLEPGHTPSQNARFILFLTAIIRAVDIHADLLRASVAVPGNEHRLGANEAPPAIISIYLGKELDTVINNIINNTDIQAPGSDDMDLGVVGFPPLPKDSTDRNRTSPFAFTGNKFEFRAVGSSQVVNFPCIVLNTIVAESLRFIREEILREMKVSSRQTAFNKIIKDTLIQHVRVVFNGDGYSGDWKELAKSRGLANLPSTPEALTNINSEKNIKLFSESNILSPVELESRQEILFEIYNKSIKIEANSLYDLVSTLVLPACFAHQKNIAESVNSIMPFIQSQKSFSQPNHQYSHLSEVVESVNLLIEANQKLLALIKQTKDFNSEHSLATFLNQSVIPQMNEVRKFSDHLEGIVEDKSWPVPKYSEILFLR
What are the official names of this protein?
Type-3 glutamine synthetase, Type-3 glutamate--ammonia ligase, Type-3 GS.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family. Type 3 subfamily.
Protein: G6PI_AGABI
Sequence: MTGSLASNYASWKQLQEIYDKDRAKIVLRDLFAADPQRFSKLSATYNSQSGPGVQILLDYSKHLVTEPILQKLFNLLREAKVEDARDKMFSGEHINTSEDRAVLHVALRNFNDFSIKEEGVDEVSKVLQHMKEFSESVRSGQWKGYTGKTINTIVNIGIGGSDLGPVMVTEALKPFSKRDLNAHFVSNIDGTHIAETLRLCDPERTLFIVASKTFTTQETITNAESARDWFLGFAKDKAHVAKHFVALSTNTSAVTAFGISEANMFQFWDWVGGRYSLWSAIGLSIALVIGFDNFEKLLRGAHAMDQHFKTTPLEKNLPAIMAALGIWCNDFYGAQTLALLPYDQYLHKFADYFQQGDMESNGKFITKNGDRVNYQTGPIIWGASGTNGQHSFYQLIHQGTKIIPADFMAPATSHNPIANSKHHRILLSNFFAQPEALAFGKTEEEVRKELGQNASEALVKSKVFEGNRPSSSLMFDKLDPATLGALIALYEHKIFVQGVVWGINSFDQMGVELGKVLAKQILAQLDKSDDVKGHDSSVRHLPFILQVDHC
What is the function of this protein?
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CCD2_LOTGI
Sequence: MKNFGLLVVCLSLATLVIPSDGVHIDGDAAPFFVVSQIQHTAGNPAVVGSSYTGRTAVAPPLNMRTNVAVPSTLGINSVNIGTNLPTFYQPTPQPVRSFKNTIDPSLLYSLMAGGLRGDGFLNQLNTIEFSSPAEVIDAVENAVENRADAIKDVIETVSGAVQNGDDEVEGIYDVFAEDDSENPVENLDDSDGVYDVFADAMEKKAEALENAAEAAAEYISDQSEEVDDLSEEVLDDDSDENDSTSSESEVEDSDVDLEVDVGIDLGGDLDLGGGVDLGGGMGMGGALNMNGGLDMGGRYGR
What are the official names of this protein?
Coiled-coil domain-containing protein 2, Uncharacterized shell protein 9, LUSP-9.
What are the subcellular locations of this protein?
Secreted.
Protein: GCSH_NOSP7
Sequence: MSFEYPQDFRYLDSHEYVRIDGEIATIGITEFAVHELGDIVFLELPEIGDALTRGENFGTIESVKAVEELNSPVTGTVIERNEALINSPEEVSEDPYGEGWFLKVRVNDPGEIEDALTADEYRAQVEGE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: Y820_HELPS
Sequence: MGRAFEYRRAAKEKRWDKMSKVFPKLAKAITLAAKEGGSEPDTNAKLRTAILNAKAQNMPKDNIDAAIKRASSKEGNLSEITYEGKANFGVLIIIECMTDNPTRTIANLKSYFNKTQGASIVPNGSLEFMFNRKSVFECLKNEVENLKLSLEDLEFALIDYGLEELEEVEDKIIIRGDYNSFKLLNEGFESLRLPILKASLQRIATTPIELNDEQMELTEKLLDRIEDDDDVVALYTNIE
What are the official names of this protein?
Probable transcriptional regulatory protein HPSH_00820.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB1_MYCMM
Sequence: MTQDHIVTERPPATRNDTAGNATARTYEVRTLGCLMNAHDSERMAGLLEDAGYIKADPGAPADLVVFNTCAVRENADNKLYGSLAHLAPIKASRPGMQIAVGGCLAQKDRHIVLDRAPWVDVVFGTHNIGSLPVLLERSRHNQDAQVEILESLRTFPSALPAARDSAYAAWVSISVGCNNSCTFCIVPSLRGKEADRRPGDILAEVQALVEQGVLEVTLLGQNVNSYGVNFADPDPSTGEEPLPRDRGAFAQLLRACGRIEGLERIRFTSPHPAEFTDDVILAMAETPAVCPHLHMPLQSGSDQILKAMRRSYRRDRYLGIIDKVRAAIPHAAITTDIIVGFPGETEHDFEQTLDVVQKARFTSAFTFQYSPRPGTPAADMPDQIPKNVVQQRFERLVALQERISLESNRSLVGTRQELLVVAGEGRKNATTARISGRARDGRLVHFRPDSADGSVRPGDLVDVEITDAAPHHLIADGPLLQHRRTPAGDASERGQTPTTRGVGLGVPRITVAQAQIPSSGTHPDTACR
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase 1, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB 1, tRNA-i(6)A37 methylthiotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_AERHY
Sequence: MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVLKALEAVNGPIAQALLGKDAKDQATVDQIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYAHIAELNGTPGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGAEVFHNLAKVLKSKGYNTAVGDEGGFAPNLKSNAEALEVIAEAVAAAGYKLGTDVTLAMDCAASEFYDAEKKEYNLKGEGRVFTSNGFSDFLEELTAKFPIVSIEDGLDESDWEGFAYQTQKLGKKIQIVGDDLFVTNTKILKRGIDNGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGAKAPFRGLKEVKNQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DBF4A_CRIGR
Sequence: MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWEKVFYLDLPSVTISEKLQKDIKDLGGRVEEFLSKDISYLVSNKKEAKYAQTLGQVSPVPSPESAYTAETTSPHPSHDGSSFKSPDRVCLSRGKLLAEKAVKDHDFIPANSILSNALTWGVKILHIDDIRYYIEQKKKELCSLKKSSTSVRDSGKKAGTTIQKARTGRLKKPFLKVEDVNRSYRPFYLQLTSVPSINYATHKPCSPFDIEKPSSVQKQAQPKPRPNTDGDKCGGTPVQLQLKEKRKKGYCECCLQKYEDLETHLLSEKHKNFAQSNQYQVVDDIVSKLVFDFVEYERDTPKKKRIKYSVGSFSSVSANVLKNTEPKEKLQLEPIFQKDMVESNGQLPEEIFQCEDIQCEDIQKPEQRLVLASEPMSYSSTGLKGRDEKAASMLNASEPDIKQKFTQLPPCKNEQEGILDVSEHKLIINRNDLEQRVGDSVGVPRSCVQVSHLSPENSLPQPKLTADTTHFSAKDLQEKDLHFVFGHDSDLVTLNTSKEQLTVKAGTPSCGPQQPNECDTENTDNLPCGKIQRKVRLLLGQKKKNVDPSAELDKKRTEFLPMCEDRTCGSPVQSLLDLFQTSGEKSDFLGFTSYTENSGLCDVLDVWEDENSSSLLSTFFSSPSASTFIGF
What is the function of this protein?
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation.  Required for progression of S phase.  The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle (By similarity).
What are the official names of this protein?
Protein DBF4 homolog A, ChDBF4.
Protein: PAN1_ASPFC
Sequence: MYSSSNSFLGGVNNARPGQPPFMQQPPYSQLPQGQQQIPQQTGFQPQPTGYGSQSASHLQPQPTGFPTGQLQPQFTGFPGAAPPQQQQQFGGYQAPAQQPQLTGYPPQSQPPSLQVPSTTGLPTRLAPRTSSEIANSFSDGAGVAPPPPPKSSGSKIPNIRLSFITAQDQAKFEQLFKSAVGDSQTMDGEKAKELLLRSRLPGSELSKIWVLSDTTKSGQLFFPEFALAMYLCNLRITGRELPSTLPDKIKNEVSGMVDIISFGVPDTEPQGAARTNVPSFDAPLLENKSAPPAPQHPKPQQPSNAQFLSQLAAQPTGFGPQATGLQPNQPSLLGANATLAPQTTGFPGQSQQQYLHSQPTGLMTNPQATGYNGPRPPLPPMPTGFGSNLSSMQTGGLAAQPTGIPGQWGFVNAPSSGLPNIEALKQQLMPQPGREGGFTTAGLSGNASIPWAITKEEKKIYDDLFRAWDGLHKGFIGGDTAIEIMGQSGLDRKDLERIWTLADPNNRGRLNMDEFAVAMHLIYRKLNGYPVPNRLPPELIPPSTRNLNDSIGAVKSLLSQDAESRKASGAFLQPQKTGVSYLKEHSFRGGARSPGFGRKDATLFKNNDEAAAGYRSSARRRVGNDARPSSPPTSQASEEELSVEQLKKKIRETQIMLDAVDFKDENRAEEDEVLDRRDRLEAESLMDRTRRVQDDIDTHPNAVFRKLDNGAERRSLRRQLQAFEDQVPQIASEVRRIEREIADAKLELFRLKDAKAHPNSAANIVGTGPGGTVTEADRIKARARARMQARAAELAGRPVPASVDDDGAAVRRLEAESASIRADREKNEAMTRDVEESVREFTRSLEDSLKEEGETSTREHERRRWEDALGVEDVIRDFIYDLQRGSRTAHIRKEEESRASAQEQRLRHEEPSPGVSRLSPAPSAGSAGSLPGSTHEDRVAAARERAQRRIAERMAAAGLKPHTDTSETLLQRQEREKREREERLRRAEEEDAKREQERQRRLAEEQRSTSDTPAKPVGKKPPPAPPSRRGRTDSAGQAEVKKAAEETITAEQAAREQAIREEQQAQEEETNRLEMEAQKREEELLKEKEAQEARLRALEEQVRQGKIRKQEEKRRKEEAERLAKEKEAALAAQRAEIERAKERERQLQLELERLDEESSSDDEGPVNITPEDSTPTQSQLLPTVTPAAPVSAPESEQAGSPEDTSSQAPPVDFKLETESKNPYFKITHQATDTQVVSSPPVPQPSFTSPKADVHSTNPFHRLAKQETSKPAFTGSAPLERKSRARPEADDDWSAAGSEFDSSDDDDDERPGGGSAKQLASILFGTMAPPRPLSAMDDKSPSKSSTPVQDSPVASLPVPESNGSLSAPAAPPPPPPPPPAAVPSYDPSVAPPPPPAPPMAPPAPPPGPPPPPGPPPPPAPPAASGPPTPAGAPDRSALLASIQKGKGLRKVQTNDRSTSSIAGRVLD
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein pan1.
What is the protein family that this protein belongs to?
Belongs to the PAN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: PARM1_MOUSE
Sequence: MVCKVLIALCIFTAGLRVQGSPTVPLPVSLMTKSSAPVATWTTSAPHTARATTPVASATHNASVLRTTAASLTSQLPTDHREEAVTSPPLKRDVNSTDSSPAGFPSTSSDGHLAPTPEEHSLGSPEATVPATGSQSPMLLSSQAPTSATTSPATSLSESLSASVTSSHNSTVANIQPTEAPMAPASPTEEHSSSHTPTSHVTAEPVPKEKSPQDTEPGKVICESETTTPFLIMQEVENALSSGSIAAITVTVIAVVLLVFGGAAYLKIRHSSYGRLLDDHDYGSWGNYNNPLYDDS
What is the function of this protein?
May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.
What are the official names of this protein?
Prostate androgen-regulated mucin-like protein 1 homolog, PARM-1.
What is the protein family that this protein belongs to?
Belongs to the PARM family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
Protein: PHY_PICAB
Sequence: MSTTRPRAATHSASSGSVSRSSKHSARVITQTPVDAKLQAEFEGSVHSFDYTKSIDISGDSSSVPSETVKAYLQRLQKEMLIQPFGCVLAVEEGSCAVVGYSENAPEMLDVVGGAHAVPSIGGQQQEGGGGGGGLLRIGMDARTLFKPASAAALQKAATFADMHLVNPIFVRCNRSGKPFYAILNRIDAGLVIDFEPVMPSDVPVSAAGALQSYKLAAKAISRLQSLPGGDIRLLCDTVVQEVRELTGYDRVMAYRFHEDEHGEVVAEMRRPDLEPYLGLHYPATDIPQASRFLFMKNRVRMICDCCAPPVNVIQDKRLRQPLSLCGSTLRAPHGCHAQYMANMGSIASLVMSVTTNENGDDSEGGGQQQPQNRRKLWGLVVCHHTSPRVIPFPLRYACEFLMQVFGIQLNKEVELAAQLREKHILRVQPVLCDMLLRDAPVGIVSQTPNIMDLVKCDGAALLYGKRLWLLGTTPTEAQILDIADWLLEHHRDSTGLSTDSLAEAGYPGAASLGDAVCGIAAARITSKDFLFWFRSHTAKEIIWGGAKHDPNDKDDGRRMHPRSSFKAFLEVVKRRSLPWEDVEMDAIHSLQLILRDSFHDIDDSDSKTMIHARLNDLRLQGIDELSAVTNEMVRLIETATVPILAIDSNGLVNGWNTKAAELTGLLADEVIGRPLIDLVQHDSVEIVKKMLYLALQGEEEQNVEIKLKTFGIQEEKGPVVLIVNACSSRDLEENVVGVCFVAQDVTWQRIAMDKFTHLQGDYRAIVQNPNPLIPPIFGADEYGYCSEWNPAMEKLTGWKREEVIGKMLVGEVFGIHRMSCQLKGQDGLTKLRIVLNNAMAGKETEKFPFSFFDRHGKNTEALLSANKRTDAEGIITGVFCFLHVTSTELQQALQVQRMAEQAAMDRLKELAYIRQEIRNPLYGIIFTRKLMESTDLSEEQKQIVQTSALCQRQLVKVLDDADLESIEDGYLELDTIEFTLGTVLDAVVSQGMILSREKGLQLIRDSPEEIKTMCLYGDQLRLQQILSNFLINALRFSTSEGWVGNKVVPTKRHLGSGVNVMHMEFRITHSGQGIPEELIKEMFVHNQDMFQEGLGLYMCQQLVKIMNGDVQYLREAGRSSFIINVEFPLAQTDKQ
What is the function of this protein?
Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region.  Photoconversion of Pr to Pfr induces an array of morphogenic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses.  Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc.  It also controls the expression of its own gene(s) in a negative feedback fashion.
What are the official names of this protein?
Phytochrome.
What is the protein family that this protein belongs to?
Belongs to the phytochrome family.
Protein: SIM32_HUMAN
Sequence: MYGDIFNATGGPEAAVGSALAPGATVKAEGALPLELATARGMRDGAATKPDLPTYLLLFFLLLLSVALVVLFIGCQLRHSAFAALPHDRSLRDARAPWKTRPV
What are the official names of this protein?
Small integral membrane protein 32.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SYT_MICLC
Sequence: MSEPKNILLTVDGELREVTHGTTGLDLFREKPTTAVMRVDGLLWDLAREIPAGASVESVDITEPEGLEVLRHSTAHVMAQAVQQLRPGAKLGIGPYITDGFYFDFDVDDPFTPEDLKQISSLMQKIVKSGQAFRRRVVDEETARAEMADEPYKLELLGKKDAADTAGEGASVEVGAGEITIYDNVDRKTGDAVWCDLCRGPHLPSTKLIGNGFALTRSAAAYWLGNEKNKQLQRIYGTAWASKDDLKAYQERLAEAERRDHRKLGAELDLFSFPDELGSGLPVFHPRGGIIRKEMEDYSRRRHTEAGYEFVYTPHITKQHLYEVSGHLDWYANGMFPPMHIDEVRDPETGEITRQGQNYYLKPMNCPMHNLIYRSRGRSYRELPLRLFEFGSVYRYEKSGVVHGLTRVRGMTQDDAHIYCTREQMKEELTTTLNFVLDLLKDYGLNDFHLELSTKDPEKFVGSDEIWEEATRTLAEVAEASGLQLVPDPGGAAFYGPKISVQARDAIGRTWQMSTIQLDFNLPERFDLEYQAADGTRQRPVMIHRALFGSIERFLGVLTEHYAGAFPAWLAPEQVVAIPVAEAFNDYLDDVVAKLRAEGIRARLDDSSDRFPKKIRTAAKEKAPFVLIAGGEDREAGAVSFRFRDGTQDNGVPVEEAIERIVKAVREREVTP
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.