PharMolix/UniProtQA huggingface dataset:
Protein: PURQ_STAAW
Sequence: MKFAVLVFPGSNCDRDMFNAAIKSGVEAEYVDYRETSLSGFDGVLIPGGFSFGDYLRSGAMASVAPIISEVKRLAAEGKPVLGVCNGFQILTEIGLLPGALLHNDSHLFISRNEELEIVNNQTAFTNLYEQGEKVIYPVAHGEGHYYCTDEIYQQLKANNQIILKYVNNPNGSYDDIAGIVNEKGNVCGMMPHPERALETLLGTDSGVKLFEAMVKSWREQHV
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARP6_CHICK
Sequence: MATLVLDNGAYNAKIGYSHAHVSVIPNCQFRSKTARLKTFTANQLDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFVDTNIIITEPYFNFSSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYKDMEIAKLKGEENTVMVDYVLPDFSTIKKGFCKPREEMVLSGKYKTGEQILRLTNERFAVPEILFHPSDIGIQEMGIPEAIVDSIQNLPEEMQPHFFKNIVLTGGNTLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYSWEGGKLISENDDFEDLVVTREDYEEHGHNICEEKFDI
What is the function of this protein?
Required for formation and/or maintenance of the proper nucleolar structure and function (By similarity).  Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (PubMed:26164235).  In the presence of high glucose, it maintains active rDNA transcription through H2A. Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A. Z (PubMed:26164235).
What are the official names of this protein?
Actin-related protein 6, gArp6, gARPX.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Nucleus, nucleolus. Note=Colocalizes with HP1 family proteins at pericentric heterochromatin.
Protein: CPS2_MARVU
Sequence: MSMTLFASVTRPGLPGPTALRFPETRHLFHSVTAFAASFSPSKSSVGSSQCNATTPPAEYKEYTGNDLAKTTVDGIEKDIHSNKGLSDKTRELVMSIRSILRTMEEGEISMSPYDTAWVAMVEDIDGGGGPHFPSTLDWISSNQLADGSWGDPIFLVYDRLINTFACVIALTSWKMHPDKCDKAISFIRENMYKLDDEKEERMPIGFEMTFPPLVEKAKRLNINFPDDSPGLRKIYAQRDLKFKRIPWDKMHTVPTTLLYSLEGMALEADVLDWQKLLKLQSPDGSLFYSPASTAFALQQTGDHNCLQYLLKLVQTFNGGVPNLYPLDLYERSWAVDRLQRLGISRFFEPQIEECMKYVHRYWSNKNGVYAARHSDIQDIDDTSMGFRVLRLNGFDVSPDAFKQFEDDDGEFLCFIGQTNHSVSATYNLYRASQVMFPGEEILQRAKKFSTKFLQDKRAENELLDKWVITKDLPGEVGYALDVPWYASLPRVEARFYIEQYGGEDVAWIGKVLFRAPNVNNDNYLELAKLDYNDCQALHQHEWKNIQQWYKSCGLRGFGLGEESLLLAYYIAAASVFEPEKSGERLAWAKTAALVKTITSQKLTKDQKHDFIREFEQGSILENANGGRCGTSNKLVETIFTTVHKMSLETSSRDIHHQLLHAWRKWVVAWEVGGDGDAELFVQTLNLTGGSSEPTPFCHPKYQQLLEVTTRICHQLRKSTVKEIQVESDMQELVKLVVTKSSGDLDSDIKQKFLTIARSFYYAAHCSTEAIGFHIVKVLFERLV
What is the function of this protein?
Involved in the biosynthesis of labdane-type diterpenoid including marrubiin and other labdane-related furanoid diterpenoids with potential applications as anti-diabetics, analgesics or vasorelaxants (Probable).  May be involved in the conversion of geranylgeranyl diphosphate (GGPP) to ent-copalyl diphosphate (ent-CPP) and 8-hydroxycopalyl diphosphate (LPP, labda-13-en-8-ol diphosphate) (Probable).
What are the official names of this protein?
ent-copalyl diphosphate synthase 2, chloroplastic, MvCPS2.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DNAJ_ACIBT
Sequence: MAKRDYYEVLGVSKTASDDEIKKAYRKLAMKYHPDRNPDNAEAEEKFKEASEAYEILSDSEKRSMYDRMGHNAFEGGFGGAGGGFGGFSAEDIFSQFGDIFGGAFGGGGRQQRQRRGSDLRYVMELTLEEAVKGVKKTITFTAPAPCDVCDGKGSKNPKDVETCKTCHGSGQVRMQQGFFSVQQTCGTCRGQGKIIKNPCHACHGSGVADRQQTLEVTIPAGVDNGDRVRLSGKGEAIRDGQAGDLYVEVVVREHEIFQRDGADLYMDVPVSIADAALGKEIEIPTLEGRVSLKIPEGTQTGKLFRLRGKGVRPVRSSMVGDLLCRIVVETPVNLTSRQRELLKELQASFDGEDSASSPKKKSFFDRLFD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOC1_COXBU
Sequence: MPKTQFQVDQNAVKKALHAAARTYDNVGMVPKAIADRLLERLDFIRLNPLCVVDVGARTGYATQQLEERYREAIVVGLDFSVAILKAASSKMMVGEYTALPFADRSVDLIFSNLAFQWSSDLQQTLQECHRVLKPGGLLLFSTVGPDTLKELHSSFADGHRHVHPFYDMHDIGDMLTQLRFTDPVMDTERLIVHYSSVPQLIKDLKQLGAQNASQDRLKGLMGKTQWRQMLTNYENCREENGALPATVEVIYGHAFGTESNSFKNANGEEVTVPIDKIIRRN
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase 1, Malonyl-ACP O-methyltransferase 1, Biotin synthesis protein BioC 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: ZN267_HUMAN
Sequence: MGLLTFRDVAVEFSLEEWEHLEPAQKNLYQDVMLENYRNLVSLGLVVSKPDLITFLEQRKEPWNVKSEETVAIQPDVFSHYNKDLLTEHCTEASFQKVISRRHGSCDLENLHLRKRWKREECEGHNGCYDEKTFKYDQFDESSVESLFHQQILSSCAKSYNFDQYRKVFTHSSLLNQQEEIDIWGKHHIYDKTSVLFRQVSTLNSYRNVFIGEKNYHCNNSEKTLNQSSSPKNHQENYFLEKQYKCKEFEEVFLQSMHGQEKQEQSYKCNKCVEVCTQSLKHIQHQTIHIRENSYSYNKYDKDLSQSSNLRKQIIHNEEKPYKCEKCGDSLNHSLHLTQHQIIPTEEKPCKWKECGKVFNLNCSLYLTKQQQIDTGENLYKCKACSKSFTRSSNLIVHQRIHTGEKPYKCKECGKAFRCSSYLTKHKRIHTGEKPYKCKECGKAFNRSSCLTQHQTTHTGEKLYKCKVCSKSYARSSNLIMHQRVHTGEKPYKCKECGKVFSRSSCLTQHRKIHTGENLYKCKVCAKPFTCFSNLIVHERIHTGEKPYKCKECGKAFPYSSHLIRHHRIHTGEKPYKCKACSKSFSDSSGLTVHRRTHTGEKPYTCKECGKAFSYSSDVIQHRRIHTGQRPYKCEECGKAFNYRSYLTTHQRSHTGERPYKCEECGKAFNSRSYLTTHRRRHTGERPYKCDECGKAFSYRSYLTTHRRSHSGERPYKCEECGKAFNSRSYLIAHQRSHTREKL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 267, Zinc finger protein HZF2.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GROA_CAVPO
Sequence: MAGAAPKTLRFAPLLLLLLLLVLGTSRRAAGAPAASELRCRCLRPVRGLHPKNIQSVAVTAPGPHCHQTEVLATLKDGREACLDPEAPMVQKVLQRMLKGSKAT
What is the function of this protein?
Has chemotactic activity for neutrophils.
What are the official names of this protein?
Growth-regulated alpha protein, C-X-C motif chemokine 1.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: AC4CH_ECO45
Sequence: MQPNDITFFQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELKKVIADIYPDQTQFYVIEFKCL
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: 5DNU_SHIF8
Sequence: MKQSHFFAHLSRLKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGNVNAERIALLAMYHDASEVLTGDLPTPVKYFNAQIAQEYKAIEKIAQQKLVDMVPEELRDIFAPLIDEHAYSDEEKSLVKQADALCAYLKCLEELAAGNNEFLLAKTRLEATLEARRSQEMDYFMEVFVPSFHLSLDEISQDSPL
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase YfbR, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK2_HEMMO
Sequence: SPPFAPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-2, PK-2, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ITB2_BOVIN
Sequence: MLRQRPQLLLLAGLLALQSVLSQECTNYKVSTCRDCIESGPGCAWCQKLNFTGQGEPDSIRCDTRAELLSKGCPADDIMEPKSLAETRDSQAGSRKQLSPQEVTLYLRPGQAVAFNVTFRRAKGYPIDLYYLMDLSYSMVDDLVNVKKLGGDLLRALNGITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKECQPPFAFRHVLKLTDNSKQFETEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKSSNEFDYPSVGQLAHKLAESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSEDSRNVVELIKNAYNKLSSRVFLDHSTLPDTLKVTYDSFCSNGKSQVDQPRGDCDGVQINVPITFQVKVTATECIQQQSFTIRALGFTDTVTVRVLPQCECQCRDASRDGSICGGRGSMECGVCRCDAGYIGKNCECQTQGRSSQELEGSCRKDNSSIICSGLGDCICGQCVCHTSDVPNKKIYGQFCECDNVNCERYDGQVCGGEKRGLCFCGTCRCDEQYEGSACQCLKSTQGCLNLDGVECSGRGRCRCNVCQCDPGYQPPLCSECPGCPVPCAGFAPCTECLKFDKGPFAKNCSAACGQTKLLSSPVPGRKCKERDSEGCWMTYTLVQRDGRDRYDVHVDDMLECVKGPNIAAIVGGTVGGVVLVGILLLVIWKALTHLSDLREYHRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
What is the function of this protein?
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4.  Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL.  Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen.  Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain.  Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain.  Integrin ITGAM/ITGB2 is also a receptor for factor X.  Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1.  Contributes to natural killer cell cytotoxicity.  Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils.  Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.  Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
What are the official names of this protein?
Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: KR122_HUMAN
Sequence: MCHTSCSSGCQPACCAPSPCQPACCVPSSCQASCCVPVGCQSSVCVPVSFKPAVCLPVSCQSSVCVPMSFKSAVCVPVSCQSSVCVPVSCRPIVCAAPSCQSSLCVPVSCRPVVYAAPSCQSSGCCQPSCTSVLCRPISYSISSCC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 12-2, High sulfur keratin-associated protein 12.2, Keratin-associated protein 12.2.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 12 family.
Protein: LUXS_SHEFN
Sequence: MPLLDSFTVDHTRMNAPAVRVAKHMSTPSGDAITVFDLRFCAPNKDILSERGIHTLEHLFAGFMREHLNGDGIEIIDISPMGCRTGFYMSLIGQPTESKVADSWLAAMVDVTNVIDQKDIPELNEYQCGTYEMHSLEQAQDIARMIIAAGVSVNQNDDLKLSDEILGNL
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: GATE_METBF
Sequence: MEKYDYSELGLKAGLEIHQQLDSKEKLFCRCPTLIRDVKESDFEFFRYLRATESEMGEKDRAAVEQTKIRRKYIYKAYDTTCLIENDEEPPRELNKEALDISLGIAKLFNMKPVDQMHVMRKIVVDGSNTSGFQRTAFLASDGFIETSQGLCGIDSLCVEEEAAQKIEEIGDSIIYSLDRLGIPLVEIATAPDIKSPRHAREVAEQIGMFLRSTGKVKRGLGTIRQDVNVSIAEGARVEIKGVQALDLIEDIIRREVERQLNLLFIRQELIERKAFVCEEIYDITGLFVDTKSKVLQKGVKKGAVLAAHLKKFEGLVGKEVQPGRRLGTEFSDRAKTAGVGGIFHTDELPNYGITEKEVKTVRDAIGASAGDAVIMVADEPEKARLAIEAVIQRAKEAMEGIPEETRKALPDGNTAYMRPLPGAARMYPETDVPQIEISQEYFDSIEIPELLTERAKRFVSENGLNQELAEKIAYSKHLPLFEELIETYGKDENVNSTLIARTLVGIVPEIRRNGVETENLTDEHFKGLFVAISNQEIAKEAIQDLLAALAEEPELSTPEAISNLGLSAFDPEEVENFIKKTVREREDFIKEKGPAALGPLMGIVMKEYRGTVDGKILSQMLKKELDSFINQG
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit E, Glu-ADT subunit E.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatE subfamily.
Protein: NHAA_CAMC5
Sequence: MCSENFKKFLVSEASGGIFLIAAAVIAMVFQNGFLSEFYNSFLHIDMGFKFGEFLLQKPLILWVNDGLMAIFFFVLGLELKREILEGELRNPAQVVLPAVGAIGGIVVPAFIFYLFNHTDSFAARGWAIPTATDTAFALGIIMILGARVPASLKIFLVTLAIIDDVCAILIMAIFYSGDLSLISFGVAAIVILGLLALNLLNVNKKSFYLILGIILWISVLKSGVHATLAGVISAFFIPLKCKNSDKSLLKEIEHDLHGYITYFVLPVFAFVNAGISLKGIGLEQLTHPVSLGVILGLFLGKQIGVFGFCFVAIKLGFAKLPKYSCWISFYGLCILTGIGFTMSLFINSLSYNDTDKFAYADKLSVLIASVISGVLGYIVLYIASVRKEKIEVKAQNESF
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DJB14_MOUSE
Sequence: MEGNRDEAEKCVQIAREALSAGNRDKAQRFLQKAEKLYPLPAARALLEIIMKNGSTAGSSTHCRKPPGSSDQSKPSCGKDGTSGAGEGGKVYTKDQVEGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGSEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAAYSHQHQHRHSGHEREEERADGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGSGQTIKMQTENLGVVYYVSKDFKSEYKGTLLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDEQLRRKADALSMENCKELERLTSLYKGG
What is the function of this protein?
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway.  Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities.  Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers.  While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70.  When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear.
What are the official names of this protein?
DnaJ homolog subfamily B member 14.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein. Note=Localizes to the endoplasmic reticulum membrane. When overexpressed, forms membranous structures in the nucleus.
Protein: GRPE_LISMC
Sequence: MSEKKNKKERLADEIEQEELNILDETEETVEEEAAADTLTEEQAKILELENKLDEVENRYLRMQADFENVKKRHIADRDASQKYRSQSLAQDLLPALDSFEKALATTSDQEEVKQILKGMEMVYNQILVAFEKEGIEVIPAVGEQFDPNFHQAVMQDSDENAGSNEITAELQKGYKLKDRVIRPSMVKVNQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RXFP1_HUMAN
Sequence: MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
What is the function of this protein?
Receptor for relaxins.  The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP.  Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
What are the official names of this protein?
Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y3511_METJA
Sequence: MGEGFKSALIIALLTSILKNGYLLIDSAEAFHHPSSLEITSQMLTKSVKNNNVQVFLTTHSLELIDFLLEHASKEGIEGRLIYMRRDGENLISSMESFENVREMRETLGIDLRG
What are the official names of this protein?
Uncharacterized protein MJECL11.
Protein: EFP_YERPG
Sequence: MASYYSNDFRPGLKIMFEGEPYAVESSEFVKPGKGQAFARVKMRRLLTGGRVEKTFKSTDSLEGADVNDMNLTYLYNDGEFWHFMNNETYEQLQADAKAVGDNGKWLIDQAECIVTLWNGQPIAVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQVGEIIKVDTRSGEYVSRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_STRA1
Sequence: MSRIGNKVITLPAGVEIINKDNVVTVKGPKGELTREFNKNIGITVEGTEVTVTRPNDSKEMKTIHGTTRANLNNMVVGVSEGFKKALEMRGVGYRAQLQGSKLVLSVGKSHQDEVEAPEGVTFEVPTPTTINVIGINKESVGQTAAYVRSLRSPEPYKGKGIRYVGEFVRRKEGKTGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: YTFE_SHIBS
Sequence: MAYRDQPLGELALSIPRASALFRKYNMDYCCGGKQTLARAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OLA1_XENLA
Sequence: MPPKKADDGPKQHPIIGRFGTSLKIGIVGLPNIGKSTFFNVLTKSQAAAENFPFCTINPNESRVPVPDDRFEFLCEHHKPASKVPAFLNVVDIAGLVKGASAGQGLGNAFLSHISACDGIFHLMRAFDDDDIIHVEGNVNPVRDIEIIREELRLKDEEMIIAALDKLEKVAVRGGDKKLKPEYDIMCKVKTWVIDEKNHVRYYHDWNDKEIDVLNKYLFLTSKPMIYLINLSEKDYIRKKNKWLIKIKEWVDKNDPGALVIPFSGVLELNLQDMSDEEKQKYLEEKMTQSVLSKIIKTGYAALQLEYFFTAGPDEVRAWTIKKGTKAPQAAGKIHTDFEKGFIMAEVMKFDDFKEEGTEASVKAAGKYRQQGRNYTVEDGDIIFFKFNTPQQSKKK
What is the function of this protein?
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency.  Has lower affinity for GTP.
What are the official names of this protein?
Obg-like ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.
Protein: NHAA_PSEF5
Sequence: MPLRSTFTRFFAMEAASGLLLIAAAILALIINNSPLSWLYNGLLETPVVAQVGALKIAKPLLLWINDGLMALFFLLIGLEVKREVLEGQLAKPSQIVLPGAAAIGGMLVPALIYWFLNRDNPPALNGWAIPTATDIAFALGVLALLGKRVPTSLKLFLMTLAIIDDLGAIVIIAIFYSGTLSTLSLMLAGACIAALVAMNRMGVVKLGPYMIIGLILWVCVLKSGVHATLAGVTLAFCIPLRTRNAEPSPLKALEHALHPWVSFGILPLFAFANAGLSLSGVTLESFTHHVPMGIAVGLLLGKTIGVFGLTWMAVKTGIAALPSGANWGQVLGVAILCGIGFTMSLFVGSLAFEPGSSEYAGMDRMGILTGSLFAALIGYAVTAAASRRNNTLAS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.