PharMolix/UniProtQA huggingface dataset:
Protein: ASF1A_HUMAN
Sequence: MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM
What is the function of this protein?
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524).  Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198).  Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807).  Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485).  Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527).
What are the official names of this protein?
Histone chaperone ASF1A, Anti-silencing function protein 1 homolog A, hAsf1, hAsf1a, CCG1-interacting factor A, CIA, hCIA.
What is the protein family that this protein belongs to?
Belongs to the ASF1 family.
Protein: RPIA_NITOC
Sequence: MSPDEMKKLAAKAALEHVEPGTIVGTGTGSTVNHFIDLLGTIKGKIEGAVSSSEASTARLKALNIPVYELNAVGEIPLYIDGADESNHYLQLIKGGGGALTREKIIAAASKKFVCIADQSKLVDILGTFPLPVEVIPMARSYVARQIVKLGGEPVYREGFITDNGNQILDTHGLSIMEPAKLEGQLNNIPGVVTNGLFAIYPADVLILGSPEGVKTIYPK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: MARA_SHIFL
Sequence: MSRRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRMTNMQGESRFLHPLNHYNS
What is the function of this protein?
May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype.  It can also activate genes such as sodA, zwf and micF (By similarity).
What are the official names of this protein?
Multiple antibiotic resistance protein MarA.
Protein: ARGJ_USTMA
Sequence: MISSLLSRSSIARRAVRGFASTAVQLDASAKLNKPARFAQPISASDIPKGFVVSSTYAGIKAAISPKPADPNTSASTAAASNPNPKPDLALIVSTVPAAAAGTFTRNVFKAAPVVVSNQVLLDGAKKEQGARVQTVLVNSGCANAVTGTQGMQDAESCVELVKKHLAPHPGLAQSSEGRETLLLSTGVIGVPLPMPTIKRCIPHLANGMILRSDPESWRETARAFMTTDTFPKLRAKTFKLGGKEVRMIGIDKGAGMIHPAMTGPAVPSAVSSGQLHATMLGLIATDAAVQPKALQVALNRAVSRSFNCISVDGDMSTNDTIILLANGQSAASSSTAVANEIDESSPDFEPFVSELTAFCQELSKLIVRDGEGAEKFVEITCTNAPSYTVAHGLLSRLVTSMLFKCAIHGQDANWGRILASVGGADPSLTKDVDASKVSVSFVDPTGEFESITVLRDGNPVKVDEDEIGKLLTKEDIKVVIDLQNGKEDCTYWTCDLSREYIEINADYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: MOAA_HALH5
Sequence: MGTQPMTDRLNRPFRDLRISVTDRCNFRCHYCMPADIFGPDYPFLKKTEILSFEETNRLVHLFHQTSPIKKIRITGGEPLMRKDVDQLISMLTATTGIEDVAMTTNGTLLPKMADKLKKAGLKRVTVSLDSLEDEQFGKINGRGIGTKPVLDGMEAAKEAGLGVKVNMVVQKGVNDQDVLPMAQFFKEKGYTLRFIEYMDVGNSNGWRMDDVVAKRDILEMIHKVHPLEPVDPEYPGEVATRYRYKGTSVEIGVISSVTDAFCTTCNRARLSVEGKLYTCLFATKGHDFRELLRSGASDEEIQQKLAAIWHVRDDKYSLKRTSLTNKRKKVEMSHIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: THIM1_CLOBJ
Sequence: MENKNVIQKMREKTPLIHCITNYVTINDCANILLSFGASPAMCEAYDEVYDFVSISSALYINLGTLTKEQETAAVLASISAKNHNVPVVIDPVGCPAIKRKVEVINRIAEVGRIDIIKGNIGEIKFLAGMDSETRGVDSLDNGENALDACTQLAKKYNCIVAATGQKDFVSDGKRGSVIKNGTEMLTKVTGAGCMLGALCAATCANFEDKLVSTTAAILSMNIAGEKAYEKAQLPGSFRIALIDNIYMISDKEIWERGNVEWK
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 1, 4-methyl-5-beta-hydroxyethylthiazole kinase 1, TH kinase 1, Thz kinase 1.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RBL1B_ALLVD
Sequence: MSTKTYDAGVKDYALTYWTPDYVPLDSDLLACFKVTPQAKVSREEAAAAVAAESSTGTWTTVWSDLLTDLDYYKGRAYRIEDVPGDKESFYAFIAYPLDLFEEGSIVNVLTSLVGNVFGFKAVRALRLEDIRFPLHYVKTCGGPPNGIQVERDRMDKYGRPFLGATVKPKLGLSAKNYGRAVYEMLRGGLDFTKDDENVNSQPFMRWQNRFEFVSEAVRKAQEETGERKGHYLNVTAPTCEEMFKRAEFAKECGAPIIMHDFLTGGFTANTSLANWCRDNGMLLHIHRAMHAVIDRNPKHGIHFRVLAKCLRLSGGDHLHTGTVVGKLEGDRQSTLGFVDQLRESFIPEDRSRGLFFDQDWGGMPGVMAVASGGIHVWHIPALVTIFGDDSVLQFGGGTQGHPWGNAAGAAANRVATEACVKARNEGVEIEKHAREVLSDAARHSPELAVAMETWKEIKFEFDVVDKLDAA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain 2, RuBisCO large subunit 2.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: DAPA_ZYMMO
Sequence: MFTGSIPALVTPFRNGKFDEVVFRAHVDRMIEGGSSALVPCGTTGESATMTIEEHNYVMAVCIDQTKGRVPVIAGCGSNDTKVSLAHLRHAAKAGAAAGLVVLPYYNKPSQEGLYAHYSYLAENSPIPILIYNVPGRTSSDISVETLARLSRLPAIVGMKDASGHIARVSAQRLACGSDFCQLSGNDDMALAFNAMGGVGCISVTANVAPKLSADFQKACAENRYQDALALQDRLYPLHSALFSDSSPAPVKYALSRLYSDFSPELRLPLVQPSDHSKALVDAALSHARLI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLCU_STAAC
Sequence: MQFLDFLIALLPALFWGSVVLINVFVGGGPYNQIRGTTLGALIVGLGLLITGFAKFNNPTVIIVGLISGALWAFGQANQLKSISLIGVSNTMPVSTGMQLVGTTLFSVIFLGEWSSMTQIIFGLIAMILLVTGVALTSLKAKNERQSDNPEFKKAMGILIVSTVGYVGFVVLGDIFGVGGTDALFFQSVGMAIGGFILSMNHKTSLKSTALNLLPGVIWGIGNLFMFYSQPKVGVATSFSLSQLLVIVSTLGGIFILGERKDRRQMTGIWAGIIIIVIAAIILGNLK
What is the function of this protein?
Involved in the uptake of glucose.
What are the official names of this protein?
Probable glucose uptake protein GlcU.
What is the protein family that this protein belongs to?
Belongs to the GRP transporter (TC 2.A.7.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HRD1_SCHPO
Sequence: MKFILYVLASLVLFGLSVLLSLYSSANVYSATVMISQSPVHITIGLNVCLCLFFAIANALKTLLFGSLQTFELELLYEQFWITLTEIMLAITVFREAISISFFMLLSTLMFARVFHSICSFRTERLQIQLTDQRFHIFSRLTCAYFVLSILDASLIYLCFTSEHLGDKSTRMLFVCEFSVLLLNLTIEASKLCIYLYEARHLDQVWDEKSTYLFRLEVCRDGLRLLAYSLLFMYQFPYVSVPIYSIRQMYTCFYSLFRRIREHARFRQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHPDHPPENTDEMEPLPRGLDMTPKRLPCGHILHFHCLRNWLERQQTCPICRRSVIGNQSSPTGIPASPNVRATQIATQVPNPQNTPTTTAVPGITNSSNQGDPQASTFNGVPNANSSGFAAHTQDLSSVIPRRIALRDGWTMLPIPGTRRIPTYSQSTSTTNPSATPTTGDPSNSTYGGPQTFPNSGNNPNFNRGIAGIVPPGWRLVSSNTQSLSTNSAMTSLYQNASSADNNLGSSLPNVVPLSRGLTQSNETSNTFPAASSNISSQLRELHTKIDELRETVSNFRADYNSIRTSLNQLEAASGINERIQTTSADSLLNSNGMSGTEGFENTQTSITTNDNQSSILTSSDQTSPFATDEDRQNSRNVQLETVDENF
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation.  Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD).  Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).  Together with ubc7, required for the degradation of the transcription factor sre1 precursor in the absence of its binding partner scp1.
What are the official names of this protein?
ERAD-associated E3 ubiquitin-protein ligase hrd1, RING-type E3 ubiquitin transferase hrd1.
What is the protein family that this protein belongs to?
Belongs to the HRD1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NDPA_SHIBS
Sequence: MSLDINQIALHQLIKRDEQNLELVLRDSLLEPTETVVEMVAELHRVYSAKNKAYGLFSEESELAQTLRLQRQGEEDFLAFSRAATGRLRDELAKYPFADGGFVLFCHYRYLAVEYLLVAVLSNLSSMRVNENLDINPTHYLDINHADIVARIDLTEWETNPESTRYLTFLKGRVGRKVADFFMDFLGASEGLNAKAQNRGLLQAVDDFTAEAQLDKAERQNVRQQVYSYCNEQLQAGEEIELESLSKELAGVSEVSFTKFAAEKGYELEESFPADRSTLRQLTKFAGSGGGLTINFDAMLLGERIFWDPATDTLTIKGTPPNLRDQLQRRTSGGN
What are the official names of this protein?
Nucleoid-associated protein YejK.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PYRB_RALSO
Sequence: MTKTFANPQLTKNGELKHLLSIEGLSRDILTHILDTAKQFVSVSDADREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSADVINLNINASSTSKGESLLDTINNLSAMQADMFVVRHASSGAPYLIAEHVAPHVHVINAGDGRHAHPTQGLLDMFTIRHYKKDFSNLTVAIVGDILHSRVARSDIHALTTLGCAEVRAIGPRTLLPSGLEHMGVRVFHSMEEGLKGVDAVIMLRLQNERMSGALLPSAQEYFKAYGLTQERLALAKPDAIVMHPGPMNRGVEIDSAVADGVQSVILNQVTFGIAVRMAVMGIVAGNND
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: THIC_MYCTA
Sequence: MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTGDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDRGTQLQRARAGEITAEMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEVDKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAELRTLGELTKIAKAHGAQVMIEGPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAMLCYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTARFEFRWNDQFALSLDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLPITQ
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: ACPS_FUSNN
Sequence: MIIGIGNDIIEIERIEKAISKEGFKNKIYTQKELENIQKRGNRTETYAGIFSAKEAISKAIGTGVREFSLTDLEILNDDLGKPYVVVSEKLDKILRNKKENYQIEISISHSRKYATAMAIIL
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUXS_SHEPA
Sequence: MPLLDSFTVDHTRMNAPAVRVAKSMATPKGDTITVFDLRFCVPNKEILSERGIHTLEHLFAGFMRDHLNSDSVEIIDISPMGCRTGFYMSLIGTPSESVVADAWLAAMQDVLNVVAQADIPELNEYQCGTYEMHSLEQAQEIARNIIAAGINVNRNDDLSLSDEILKGL
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: RIB73_ECOLX
Sequence: MLTQLKKNGTEVSRATALFSSFVEKNKVKCPGNVKKFVFLCGANKNNGEPSARRLELINFSERYLNNCHFFLAELVFKELSTDEESLSDNLLDIEADLSKLADHIIIVLESYSSFTELGAFAYSKQLRKKLIIVNNTKFINEKSFINMGPIKAITQQSQQSGHFLHYKMTEGIESIERSDGIGEIFDPLYDILSKNDRAISRTLKKEELDPSSNFNKDSVRFIHDVIFVCGPLQLNELIEIITKIFGTESHYKKNLLKHLGILIAIRIISCTNGIYYSLYKEYYFKYDFDIDNISSMFKVFFLKNKPERMRVYENI
What is the function of this protein?
Possible ribosyltransferase/DNA-binding component of antiviral defense system retron Ec73, composed of a non-coding RNA (ncRNA) followed by this protein then a reverse transcriptase (RT).  Expression of this retron confers protection against bacteriophages SECphi4, SECphi6, SECphi27 and P1.  At multiplicity of infection (MOI) of 0. 02 cultures grow normally when infected with SECphi4 without collapsing, at MOI 2 cultures enter growth stasis.
What are the official names of this protein?
Retron Ec73 putative ribosyltransferase/DNA-binding protein, Orf316.
Protein: RL14_GEOSM
Sequence: MIQMQTLLDVADNSGAKKLFCIKVLGGSKRRYAGIGDIIVASVKEALPNSKVKKGDVVKAVVVRTAKAVGRPDGSYIRFDTNSGVVINNAKEPVGTRIFGPVARELRAKKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PRIO_RUPRU
Sequence: MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: RF1_XANCB
Sequence: MTPTLRRKLEALAERREELQHLLSDPEVVSNNDKFRSLSRELSQLEPVALAMQEEARAKADLSAAEAMRNDPEMRELAEEEILAAQARLDELDAQLALLLVPRDPRDEGNLFLEVRAGTGGDEAAIFAGDLFRMYARYAERQGWKVEIESDSPGEHGGYKEVVARVVGRGAYSRLKFESGTHRVQRVPATESQGRIHTSAATVAIIPEADDVEEIVINPADLKVDTFRSSGAGGQHVNKTESAIRITHVPSGVVVECQTERSQHANRDKAMKRLKAQLVEAERSKAAAAEAQTRKLQVGSGDRSQRIRTYSFPQGRITDHRVEGLTLYDLPNIIEGDLDALIARLLHEHQADELARLSEGT
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGAA_DICDI
Sequence: MNKEEYSDISDSESEEVHETNNHNEHEHEEEDDTPEIVVPERKFLKEDEDYSVPFPVMRECLVLLLQSRRILRDMMYYRFKMDRFLSGNLSVFEIQNLLHSQREDKESDWIAEIQELKRNLVSEVRRNHTLERDLNRLDKRIALLIKNRGNIQDVLADKAGLKAPKHKGDQKKPELINDPKKLEAYQNLFYLLQTEPKYLAGLVYLIQPEQMESFLGTVILTLFGDAFTPREEFLLLSLYRLSIQKEMANIATVGDFLKADTVVPKMIITYNKRKQGTDYLKAVIGPILSNVIKQELNLELKPNLVYAAIISEQEIRTGEKSTLDRNVSHEKALEVPEVTKTIKARVDQLISICEQFLDGIISSLNRLPYGIRWICKQIYQIAEKNFTKSTQDEILKVIGYFIYYRFIQVAMVSPEEYDLVGREIHPTARKNLINVSKVLQALFNFAQFGSSEKHFIPLNGWITSHMGDIKNYLQEIIEVGEPEDYLQVDKYMELTQKTKPVIIISLPEICNTHQLISKNLDSLVAKGEKDDPMRIIMKELDEFGPPPDIAADDDREVQLTLSNKFQKTIEEELSPGESLLSQTKEMVISLLRALPTLPEQKDQSDEPPNLVDVLNKARQADPSLEPEIKKILDNLKKLEEYNLTTSADNYSSFLKAVALEVVNRAEIREQQKKEKQRLTTSLNNLRKHQKYLNEQIAQYNQYLQDCRLKHYQNKSKKKKKGDGAKVGPFKFSFSELHKKGVIVDSEVPQITRKKIKFVISSDTVGVFDVSAKMAGIDVQTMRLELDDLLELNSIGTTTLELDQITLDVNMTIHLLNKLFLY
What is the function of this protein?
Part of signaling pathway that is required for completion of cytokinesis.  gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton.  Forms a complex by linking activated rac1A to ctxA.  Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell.  Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cytokinesis.
What are the official names of this protein?
Ras GTPase-activating-like protein rgaA, DGAP1, Developmental gene 1029 protein.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cleavage furrow. Note=Enriched in the cortex of interphase cells and translocated to the cleavage furrow during cytokinesis.
Protein: NANE_VIBCH
Sequence: MRPVVRKNFLNIEELKRFLNGQTVVSIQPVTGSPLDKTDFIVAMAIAVEQAGAKALRIEGVNNVAAVSAAVTIPIIGIVKRDLPDSPIRITPFVSDVDGLANAGATVIAFDATDRTRPESRERIAQAIKNTGCFAMADCSTFEDGLWANSQGVEIVGSTLSGYVGDIEPTVPDFQLVKAFSEAGFFTMAEGRYNTPELAAKAIESGAVAVTVGSALTRLEVVTQWFNNATQAAGERKCAH
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: ST1B1_BOVIN
Sequence: MTSPKDVLRKNLKLIHGCPITYAFANNWEKIEQFQSRPDDIMIVTYPKSGTTWISEIVDMVLHDGDVEKCKRDVITAKVPMLELALPGLRTSGLEQLEKNPSPRVVKTHLPIDLIPKSFWENNCKIIYLARNAKDVAVSFYHFDLMNNLQPLPGTWGEYLEKFLTGNVAYGSWFNHVKSWWKKKEGHPILFLFYEDMKENPKQEIKKVVRFLEKNLDDEILDKIIYHTSFEMMKDNPLVNYTHLPSEVMDHSKSSFMRKGIAGDWKNYFTVAQNEKFDAIYKKEMSETELQFRTEI
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine small phenols such as 1-naphthol and 4-nitrophenol (PubMed:25539458).  Catalyzes also the sulfate conjugation of dopamine and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (By similarity).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
What are the official names of this protein?
Sulfotransferase 1B1, ST1B1, Sulfotransferase family cytosolic 1B member 1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ATPL_CLOPE
Sequence: MDMKLLAAGIAVLAGIGAGIGIGIATAGALEATARQPEASDKIQSLFIMGAGLSEATAIYGLVVSIILLFVA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DBX1A_DANRE
Sequence: MMIPSVIAPPAIYSAFMRPAASLHSPFPAHPSFLVEDLLRINRPSGFLSQTAHSPCASPPNSTPLSIPDNCRILDRVSPGITEKHGPCSPKTPVSSKDPTYLKFGVSAILAPSPKKATSPPSVHSIHPKGFSVPYFDGSFCPFVRSSYFPAPSSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKTNPHPDLSDVGKKSSEDEDEDDACAPSHFCLSPRRVMSNSTDSSITFKHSDFSESEDEITVS
What are the official names of this protein?
Homeobox protein DBX1-A, Developing brain homeobox protein 1-A, Homeobox protein hlx1.
What is the protein family that this protein belongs to?
Belongs to the H2.0 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH60_PELUB
Sequence: MAKVVKFDSEARAAMIRGVDILANTVKVTLGPKGRNVVIDKSYGAPRITKDGVSVAKEIDLEDKFENMGAQMVKEVASKTNEEAGDGTTTATILAQAIVKEGVKYVTAGMNPMDVKRGIDAAVEHVKASLIASAKKVKDTDEIAQVGTISANGDKEIGNMIAKAMQKVGNEGVITVEEAKGVETELDVVEGMQFDRGYLSPYFITNADKMTTELENPFILLHEKKLTNLQPMVPLLEAVVQAGRPLMIISEDVEGEALATLVVNKLRGGLKVVAVKAPGFGDRRKSMLDDIAILTGGQVISEDIGVKLENVKLTDLGSCKRVKVDKDNSTIISGNGKKSEIEARCAQIKQQVGETTSDYDREKLQERLAKLAGGVAVIKVGGATEVEVKERKDRVEDALNATRAAAEEGIVVGGGCALLYASQSLDTLKVKGDDQKAGVALVAKALQAPIRQITLNAGVDGSVVVGKLLEQNKKNMGYDAQNEEYVDMFAKGIIDPVKVVRTALQDAASIAGLLVTTEAMIADKPDDKDSGAGGMSGGMPGGMGGMGGMGGMGM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_CAUVC
Sequence: MLPDIGGTELLIIAAVALIVVGPKDLPALLRKVGQFVGRMRGMASEFRASFDEMARQSELDELRREVQAMRSGQFTNPVQDAADAARDVQVDQVFADIDASLSSGAMQAHPYAAGETHNSILPTAEPSAEIVEAKPKRAPRKKAVAEPVAAEPVLVEPVKAPRKRASQKQEITVEAPKAVRAPRKRASKAGDSTASDIVS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.