PharMolix/UniProtQA huggingface dataset:
Protein: PDX1_STELP
Sequence: LIKEIKAAVTIPVMAKARIGHFVEAQILESIGVDYVDESEVLTPADEDHHINKHNFQIPFVCGLSIPRGAPPPAYRRGYAGHDTGPRVRKPSTGNVVEAVRHIRSVMGEIRLLRNMDDDEVFAYAKKISAAYDLVMQTKQLGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGVFKSGDPAKRARAIVQAVTHYSDPDLLGRGEFGLGEAMVGIIVRMRRLRGTPIVLNEVI
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by PDX2.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.  Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.
What are the official names of this protein?
Probable pyridoxal 5'-phosphate synthase subunit PDX1, PLP synthase subunit PDX1, H47.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: HPRK_NEIMA
Sequence: MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQHNENRPD
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: ZBT16_HUMAN
Sequence: MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV
What is the function of this protein?
Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566).  Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654).  May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues.  Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 16, Promyelocytic leukemia zinc finger protein, Zinc finger protein 145, Zinc finger protein PLZF.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nuclear body.
Protein: SYV_NANEQ
Sequence: MPYNPKEIEQWYKENYKYFFGEGDKILIIDTPPPYPAPLWHIGAALSYALQDFIARGFRKLGYKVIFPEGFDGNGIPIEMYLEKYEKIPFGSIDREEYIKKCRQILDSWREKMDKILKDLLLSMDFEHRYNTDDPEYRALTQKTFAELWEKGLIYEAEYPINYCPHCKTAIADAEIERKIKKTKLVYIKFKIKDSDDYITVATTRPELLGACKAIIVHPDDERYKKYHNKIAIVPYYNREIPIIPHKMADPNFGTGAVMICSYGDWVDVQIFRELQLKPEKIIDENGRLTIEPVKGLTTKEGREKMIEVLKQLGVVEKIEEIEHSVPVHERCETEIEIIPMKEFYLKQLPFKEEIKKLSKEIEFIPERYRKNLENWIDSITIDWPISRRRWYATEIPLWYCPKCGYIHVAKDGKYHQPWKEEMVCPRCNTKMVGETRVLDTWMDSSITIYYLIKKYSKILGIDEEGLFNNYTLRPQGYEIIRTWLYYTLLRVYQLTGKKAFDFVVINGMGLDKHGRKMSKRYGNVIEPETLLEKYGADTLRYWFAMEISIGEDYRINEQKIAGIMKFMNKVWNIANYISQYQYRETQNLKPTDEWIINYVKYLENKAIEYIRNFEFNKLARELYRFVWDVFANHYIELTKKRAKNNDDSAIYALYFVFERVLNMLSIFSPGIAKYLAKKLYNKDIEKEKLKYWGKVRLDLLYKGEKLIEFNNYVWKLKTSQGKKLKDPISIEIPKELEIFKEDLILLHNIQ
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity).
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVE1_SCHPO
Sequence: MLRLLKRNIQISKRIVFTILKQKAFKGNHPCVPSVCTITYSRFHCLPDTLKSLLPMSSKTTLSMLPQVNIGANSFSAETPVDLKKENETELANISGPHKKSTSTSTRKRARSSKKKATDSVSDKIDESVASYDSSTHLRRSSRSKKPVNYNSSSESESEEQISKATKKVKQKEEEEYVEEVDEKSLKNESSSDEFEPVVPEQLETPISKRRRSRSSAKNLEKESTMNLDDHAPREMFDCLDKPIPWRGRLGYACLNTILRSMKERVFCSRTCRITTIQRDGLESVKQLGTQNVLDLIKLVEWNHNFGIHFMRVSSDLFPFASHAKYGYTLEFAQSHLEEVGKLANKYNHRLTMHPGQYTQIASPREVVVDSAIRDLAYHDEILSRMKLNEQLNKDAVLIIHLGGTFEGKKETLDRFRKNYQRLSDSVKARLVLENDDVSWSVQDLLPLCQELNIPLVLDWHHHNIVPGTLREGSLDLMPLIPTIRETWTRKGITQKQHYSESADPTAISGMKRRAHSDRVFDFPPCDPTMDLMIEAKEKEQAVFELCRRYELQNPPCPLEIMGPEYDQTRDGYYPPGAEKRLTARKRRSRKEEVEEDEK
What is the function of this protein?
Endonuclease for the repair of UV-irradiated DNA.  Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway.  Functions also in oxidative damage repair in vivo.  Provides back-up AP endonuclease activity to apn2 together with apn1.
What are the official names of this protein?
UV-damage endonuclease, UVDE.
What is the protein family that this protein belongs to?
Belongs to the uve1/UvsE family.
Protein: LEUC_SACS2
Sequence: MMSAKTLTEKILSRASGKDVSPGDVIEAKVDLVAFHDLTGYHVIEVMEKANMIKVFDKSKLVIAFDHLAPPPDVRSAEIQGYIRKFVKSEGIPNFYDINYGILHEVMIEQYANPGQVILAADSHTTTSGAVGAFAQGMGASDIAAALITGKTWLVVPQPFKVVLEGKPAKWITGKDVALKLLGDFKADYFNGMTLEIFVKDPLSFPMDYRATVSNMGIEMNADALMFIPDQETKRYIKEMRGYEPELVTPDNGAKYVDEYTIQLDEMEPLVAAPHSVDNVKVVNELEGTPVDQVYIGSCTNGRLSDFEIAAKIMKGKKVKSRCIAIPASYRMFKEALERGYIQTLVDAGCIVTYGTCGPCLGGHFGIAGPGENIVSTSSRNFKGRMGSNEAKVYLSGPAVAAISALEGKITDPRVI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: ARGR_BACC3
Sequence: MNKGQRHIKIREIIANKEIETQDELVDILRNEGFNVTQATVSRDIKELHLVKVPLHDGRYKYSLPADQRFNPLQKLKRNLVDSFVKLDTAGHMLVLKTLPGNAHSLGALIDHLEWDEIIGTICGDDTCLIICRTPEDTGVVSDRFLNML
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG54_BPML5
Sequence: MSKRIVVISDTQIPFDDRKQLKAVIGYIGDTQPDEVVHIGDLMDYPSPSRWTKGTKEEFAQRIKPDSEQCKRRFLEPLRQVYDGPVGVHEGNHDRRPVDYLHQFAPALVEYVSSFQFQNLLDFDGFGVDVLPEFYKIAPGWISTHGHRGGVRVTQKSADTAYNAMMRFGTSVIIGHTHRQGIKPHTLGYGGNQKVLWSMEVGNLMNMKLAQYLKGATANWQSGFALLTVDGQHVKPELVPIVGGRFSVDGRVWEV
What are the official names of this protein?
Gene 54 protein, Gp54.
Protein: MSRA_STRS7
Sequence: MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHVPNPSYEQVCSKTTGHTEAVEIIFDPSLISYSDLVELYWAQTDPTDAFGQFEDRGDNYRPVIYYTDERQREIAERSKQTLQASGRFDQPIVTSIKPAEPFYLAEDYHQGFYQKNPERYAQSSAIRHQFLEEHWQ
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: FOLD_ECOL6
Sequence: MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDALNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQGE
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SEC9_KLULA
Sequence: MGIKKFFKIKPPPEATPEENREYLNELGISTKTTPSNRREKFAAYGKFANDKVKSKVYAPEGYEQYANPGAQPSERQQLDDLNNSPYDEVSMINNRNASASARHTGNYVDPYSNDNASPYGNSDSSPYGNASASPYDTGYNAPLQQNNNPYGSMNNSYSNKSYGSNSYSGDTYASPSPQASSSNNNGATGQRPSNPYANMNSQDPYGTNSYSNSGSVNAYKGFTPNVAASDVSSRSYASPRHSTSATRSNDREFNFERSGADDEIDLNETIRPEIDNPKGVQRNGNGDDDDLNNSIHENEGIGTPAKGYQTFEDIQKESQRAEQQEEDEEVDGIKQQIKFTKQSSVASTRNTLKMAQDAELAGMNTIGMLGHQSEKLNNVERNLNLMQIQNRVADDKVSELKKLNRNILAVHVSNPFHSKRRAREAEDKIKLQRMQDKQNQEDITSTLHQSTKRIENAMSSGHGPSEVRDRYQNQQILEKAKRYQFENDEEDDEMEMEIDKNLDKIGQISGRLKKLAITTGKEIDSQQDRIKRIEESTDDLDIKIHVNTTRLTNIR
What are the official names of this protein?
Protein transport protein SEC9.
What is the protein family that this protein belongs to?
Belongs to the SNAP-25 family.
Protein: TX85A_SCOAL
Sequence: MIFSRIMRGLLCLCLVLTVFELINGSDEFEHQDSLHLVKRLWRNWEEDQQKDREKRLWRNWEEEEQKDREKRLWRNWEEEEQKEKRNLPELKYEMEKNQEVPQLKRKRGILEKIWIPNEIGR
What are the official names of this protein?
U-scoloptoxin-Sa5a, U-SLPTX-Sa5a, U-scoloptoxin-Er5-like, U-SLPTX-Er5-like.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-08 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL11_PROM1
Sequence: MAKKVVALIKLALQAGKANPAPPVGPALGQHGVNIMAFCKEYNSRTQDKAGFVIPVEISVFEDRSFSFITKTPPASVLITKAAGIAKGSGESAKGSAGSISTSQLEEIAKTKLPDLNCSSIESAMKVIEGTAKNMGVSIKD
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: DAPF_DESRM
Sequence: MYFTKVHGLGNDFILVNAGTGQGFTDDCSTLAKEVCDRKFGIGADGLVLLYDSGVADVRMKIVNSDGSEAEMCGNAIRCVAKYLYDHGIIKKDEIKVETLAGIIVPQIIQQEGSVKAVRVDMGEPRVERAEIPMIGPPGQVIGEELAVNGKVYLVTAVSMGNPHCIIFVPDLEDISLTQVGPQIEVHPAFPKKTNVEFVQVLGPNEVRMVVWERGAGPTMACGTGACAVAVAGVLNGFTERMVTVHLPGGSLMIEWAENGRIYMTGPATEVFSGEYTVYNPSRR
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETT1_YEAS7
Sequence: MAKRPLGLGKQSREKKRKVESVEKKSDEPSRESTPVRSQMSVELDDDADLDDELAQLKGLWSKYFHSDRDDEYVLNGIVHECDRLLRLSEEDKEIKKTLNDIFHGIYALALSELTIFKAGDEEATEEKRKKDVSSFFENAIERVELGLSHFPESQFLKLVLAKIIFQRIPLEYISNLHLKSKDKKLDLVGQLEHGKKHFSIYENDTEFTFEILQMVNDLLDIVENFGREQSIQEGIDSDNEEEEELIDIELEPEHPVYPLQQSLEANYEWLRNHFDKLLDNTNTDMKIYASIANTLGELYLKKAEEPSKVFLSLQYDDGSSKKVSDKEAKNVQETALKHTKKALEYLEKAKLEDDPDTWVQVAEAYIDLGNLLDNESAEQEEAYKTAEEILGKANKASHGKFQDVLDNFLQG
What is the function of this protein?
Required for correct translation termination and probably involved in regulation of hypoxic gene expression in association TPA1.  Inhibits replication of Brome mosaic virus (By similarity).
What are the official names of this protein?
Enhancer of translation termination 1.
What is the protein family that this protein belongs to?
Belongs to the ETT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VATD_STRPQ
Sequence: MARLNVKPTRMELSNLKNRLKTATRGHKLLKDKRDELMRRFVDLIRENNELRQTIEKELAANMKEFVLAKASENSLMVEELFAVPVHEVTLWIDIENIMSVNVPKFHVQSNTAREQEQGEFAYSYLSSNSEMDNTIQKTKELLEKLLRLAEVEKTCQLMADDIEKTRRRVNGLEYAIIPQLEETIHYIELKLEEAERASLVRIMKITS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: EI3D1_DROSE
Sequence: MSETINTAAQFPSFEKPTVQFNEKGWGPCELPDTFKDVPYQPFSKNDRLGKICDWTNTSNNDKKYQNKYASSFGTGNQYSYYHEEDETTFHLVDTARVQKPPHQRGRFRNMRNSRSGRGRNARGGLNTHGMTTLSGKNVKARDPRHGRGMGKKFGHRGPPPKMRESSVAVRADWASIEEMDFPRLIKLSLPNIKEGVDIVTCGTLEYYDKTYDRINVKNEKPLQKIDRIVHTVTTTDDPVIRRLSKTVGNVFATDAILATIMCSTRSNYSWDIVIEKVGDKVFMDKRDHTEFDLLTVNESSVEPPTDDDSSCNSPRNLAIEATFINHNFSQQVLKTGDQEPKYKFEESNPFISEDEDIQVASVGYRYKKWELGSDIVLVARCEHDGVLQTPSGEPQFMTIKALNEWDSKLANGVEWRQKLDTQRGAVLANELRNNACKLAKWTVQAVLAGSDQLKLGYVSRINPRDHSRHVILGTQQFKPHEFATQINLSMDNAWGILRCIIDLVMKQKDGKYLIMKDPNKPIIRLYDIPDNTFDSDDSDDGEGDDEGFQQVYNYAHNKI
What is the function of this protein?
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit D-1, eIF3d-1, Eukaryotic translation initiation factor 3 subunit 7-1, Eukaryotic translation initiation factor 3 subunit p66.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL3_POLNS
Sequence: MSLGLIGRKVGMTRLFTDEGEAIPVTVIDVSDNRVAQIKTQATNGYDAIQLAHGTRRATRVTKAMAGHFAKAGVMAGNALNEFHLDAAKIAEMTPGQVIPAETAFTAGQKVDVQGVTIGKGYAGTIKRYHFASGRASHGNSRSHNVPGSIGMAQDPGRVFPGKRMTGHLGDITRTVQNLVIARIDAERNLIMVKGAIPGAPGGKVIVTPAVKTPLKKK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RIMO_AQUAE
Sequence: MKIGVVSLGCAKNLVDSEILLGKLKGAGVELTPNPEEADVIIVNTCGFIEPAKLESIETILEFAESGKEVIVMGCLVERYKEELEKEIPEVKAYFGTESWNEILNYLGLKEKKEIKRILSTPRSYAYLKIAEGCNRLCSFCAIPKIRGRHRSRKIEEIVDEAKFLADQGVKEICVVSQDTTYYGKDLYKEYKLVELLEGLEKVEGIKWIRLLYLYPTEVHEDLIDYVANSEKVLPYFDVPLQHVSDRVLKDMRRGYDGKFVRNLIENIRKKIENAVFRTTFIVGFPTESEEDFKELKKFVEEGHFHWLGVFTYSPEEGTHAYPLGDPIPREVKEERREELMAIQRGITRKKNEEFLGKEIEVLIDGYEEEFSFVPKGRAYFQAPEVDGVVYVESSRDLKSGDILKVKVTQVADYDLAGRDTEALDLIFSSEE
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLRA2_HUMAN
Sequence: MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
What is the function of this protein?
Glycine receptors are ligand-gated chloride channels.  Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488, PubMed:26370147).  Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677).  Plays a role in synaptic plasticity (By similarity).  Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability (PubMed:25445488).  Plays a role in cellular responses to ethanol (PubMed:23895467).
What are the official names of this protein?
Glycine receptor subunit alpha-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Cell membrane; Multi-pass membrane protein. Cell projection.
Protein: MEP2_YEAST
Sequence: MSYNFTGTPTGEGTGGNSLTTDLNTQFDLANMGWIGVASAGVWIMVPGIGLLYSGLSRKKHALSLLWASMMASAVCIFQWFFWGYSLAFSHNTRGNGFIGTLEFFGFRNVLGAPSSVSSLPDILFAVYQGMFAAVTGALMLGGACERARLFPMMVFLFLWMTIVYCPIACWVWNAEGWLVKLGSLDYAGGLCVHLTSGHGGLVYALILGKRNDPVTRKGMPKYKPHSVTSVVLGTVFLWFGWMFFNGGSAGNATIRAWYSIMSTNLAAACGGLTWMVIDYFRCGRKWTTVGLCSGIIAGLVGITPAAGFVPIWSAVVIGVVTGAGCNLAVDLKSLLRIDDGLDCYSIHGVGGCIGSVLTGIFAADYVNATAGSYISPIDGGWINHHYKQVGYQLAGICAALAWTVTVTSILLLTMNAIPFLKLRLSADEEELGTDAAQIGEFTYEESTAYIPEPIRSKTSAQMPPPHENIDDKIVGNTDAEKNSTPSDASSTKNTDHIV
What is the function of this protein?
Transporter for ammonium (both charged and uncharged NH3 and NH4) to use as a nitrogen source (PubMed:11069679, PubMed:11486013, PubMed:9234685, PubMed:9482721, PubMed:16477434, PubMed:18434596, PubMed:24476960, PubMed:27088325).  The affinity of MEP2 is about twenty times higher than that of MEP1 (PubMed:9482721).  MEP3 has the lowest affinity (PubMed:9482721).  Under ammonium limitation acts as an ammonium sensor, generating a signal that leads to pseudohyphal (filamentous) growth (PubMed:9482721, PubMed:11069679, PubMed:16477434, PubMed:18434596, PubMed:32069286).
What are the official names of this protein?
Ammonium transporter MEP2.
What is the protein family that this protein belongs to?
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: H2B1O_HUMAN
Sequence: MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 1-O, H2B-clustered histone 17, Histone H2B.2, Histone H2B.n, H2B/n.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PTSS1_DANRE
Sequence: MATTFRSQTLSKDDVNYRMHFRMINEQQVEDITIQFFYKPHTISLLTVTVLSLMYFAFTRDDGDPDSNLRVGLILLVSFFLVISVLAFPNGPFTRPHPAIWRIVFGLSVLYFLFLVFIIFLNWDQVKALMFWLDPNLRYAKREADVMEYAVNCHVITWERILSHFDIFAFSHFWGWGMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMTVCRFLEMRTYHWASIKDIHSTTGKIKRAVLQFTPASWTYVRWLDPKSSLQRVMGVYLFMIIWQLTELNTFFLKHIFVFPACHALSWCRILFIGIITAPTVRQYYAYLTDTQCKRVGTQCWVFGAIAFLEALACIKFGQDLFSKTQILYVILWLVCLAFITFLCLYVMVWYAENYGPRQKSFSECEDSIYSEAGDSVTECKGEFEIDSTTSCSTRKRRDSGDSRTINGMEK
What is the function of this protein?
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity).  Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
What are the official names of this protein?
Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I.
What is the protein family that this protein belongs to?
Belongs to the phosphatidyl serine synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Protein: FLII_HUMAN
Sequence: MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA
What is the function of this protein?
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1.  Involved in estrogen hormone signaling.  Involved in early embryonic development (By similarity).  May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
What are the official names of this protein?
Protein flightless-1 homolog.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity).
Protein: YIDD_BEII9
Sequence: MRRFVRSLSSTGRSQTGSLPVRGLRKLLRFYQLTFSSLVGTQCRHLPTCSAYMDEALARHGVWAGLFIGLARLSRCHPWGTAGYDPVPDQLDANVPRLQPWRHGRWRGPLEITWKPEHKDQNL
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.