PharMolix/UniProtQA huggingface dataset:
Protein: UBE2N_MOUSE
Sequence: MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
What is the function of this protein?
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:22424771, PubMed:28039360).  This type of polyubiquitination does not lead to protein degradation by the proteasome.  Mediates transcriptional activation of target genes.  Plays a role in the control of progress through the cell cycle and differentiation.  Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.  Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair.  Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.  Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.  Together with RNF135 and UB2V1, catalyzes the RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:22424771).  UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 N, Bendless-like ubiquitin-conjugating enzyme, E2 ubiquitin-conjugating enzyme N, Ubc13, Ubiquitin carrier protein N, Ubiquitin-protein ligase N.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: OHP2_ARATH
Sequence: MSVASPIQCIRILNPSSSSSSSTASSSFRFSTTTKPCVFIIRCSQTEGPLRRPSAPPTLREPQKPVPPSQPSSSPPPSPPPQKAVAVDGKSVTTVEFQRQKAKELQEYFKQKKLEAAGQGPFFGFQPKNEISNGRWAMFGFAVGMLTEYATGSDLVDQVKILLSNFGILDLE
What is the function of this protein?
May play a photoprotective role within PSI in response to light stress (PubMed:12805611).  Forms a trimeric complex with OHP1 and HCF244 that is required to promote PSII core subunit assembly (PubMed:29930106, PubMed:30397023).  The trimeric complex forms a transient PSII reaction center-like complex with PsbA, PsbD, PsbE, PsbF and PsbI subunits in thylakoids for early assembly of PSII as well as PSII repair (PubMed:30397023).  The trimeric complex is required for the recruitment of ribosomes to the psbA mRNA during PSII biogenesis and repair (PubMed:31991763).  Forms an heterodimer with OHP1 that binds chlorophylls and carotenoids, and that may function in the delivery of pigments to the PsbA subunit of PSII (PubMed:32071152).
What are the official names of this protein?
Light-harvesting complex-like protein OHP2, chloroplastic, One-helix protein 2, Protein LIGHT-HARVESTING LIKE 6.
What is the protein family that this protein belongs to?
Belongs to the ELIP/psbS family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein. Note=Associates with PSI under low or high light conditions.
Protein: INT12_XENLA
Sequence: MAVTINTELDPVFLKALGYLHSKSKDSAEKLKALLDESLCKGNDSVYRPQPKEVEQPKAMLSKVKPETKASSSTPSSSILSKPLASEKVKKEAEKRTADKMKVEINDIMDIPKKPRIEKTEARSSPVTVQLSKDLPVPDLSSFEETSADDFAMEMGLACVVCRQMTVFSGNQLVECQECHNLYHQDCHRPQVTDKDVNDPRLVWYCARCTRQMKRMAQKNQKPSQKPAPSAVSAVTPVAKDPSVNKPELKSKSDSANTFLAFKRAEVKASSAVSSNPSNSGVSSSSASGLTGWAAFGAKTASAVPVSGKLGTNSQATSGKPPSLSSVQKAGTVPGLTPSKAGSVSKSGSGGSSSTIPLKPLPPLILGKTGLSRSMSSDNVSKTGLPSPNPSSSGSVSSLSSQLGSNNGSSNTAGSNVNSSNKVAVDPSMQQSGAKGPTSQESQLNAMKRLQMVKKKAAQKKLKK
What is the function of this protein?
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
What are the official names of this protein?
Integrator complex subunit 12, Int12.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZFP64_MOUSE
Sequence: MNASVEGDTFSGSMQIPGGTTVLVELAPDIHICGLCKQHFSNLDAFVAHKQSGCQLTTTPVTAPSTVQFVAEETEPATQTTTTTISSETQTITVSAPEFVFEHGYQTYLPTESTDNQTATVISLPTKSRTKKPTAPPAQKRLGCCYPGCQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERPFKCQICPYASRNSSQLTVHLRSHTASVLENDVQKPAGLPAEESDAQQAPAVTLSLEAKERTATLGERTFNCRYPGCHFKTVHGMKDLDRHLRIHTGDKPHKCEFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDERPYKCQLCPYASRNSSQLTVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSGEKPFKCEFCDVRCTMKANLKSHIRIKHTFKCLHCAFQGRDRADLLEHSRLHQADHPEKCPECSYSCSNPAALRVHSRVHCTDRPFKCDFCSFDTKRPSSLAKHIDKVHREGAKTENRAPPGKDGPGESGPHHVPNVSTQRAFGCDKCGASFVRDDSLRCHRKQHSDWGENKNSNLVTFPSEGIATGQLGPLVSVGQLESTLEPSHDL
What is the function of this protein?
May be involved in the regulation of mesenchymal cell differentiation through transactivation of NOTCH1 target genes.
What are the official names of this protein?
Zinc finger protein 64, Zfp-64.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CCL3_HUMAN
Sequence: MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA
What is the function of this protein?
Monokine with inflammatory and chemokinetic properties.  Binds to CCR1, CCR4 and CCR5.  One of the major HIV-suppressive factors produced by CD8+ T-cells.  Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
What are the official names of this protein?
C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, PAT 464.1, SIS-beta, Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein.
What is the protein family that this protein belongs to?
Belongs to the intercrine beta (chemokine CC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLC4A_RAT
Sequence: MASEITYAEVRIKNESNSSVTYSGSPAAPREKPTRHLSKPGSLLVPFTSLMVLLLLLAITFLVAFIIYFQKYSQFLEEKKAIKGITHKELNCIKNVLLMEEKSWSCCPKNWKPFGSHCYWVTKHTSTYSKASWSESEKNCFSMGAHLLVIHSKEEQDFITGILNRDAAYFIGLWDSGHRQWQWVSQTPYNASATFWHKGEPSSDDEKCVIINHLNSGWGWNDIPCSGKQQSVCQMKKIQL
What is the function of this protein?
C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner.  Involved in regulating immune reactivity.  Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells.  This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13.  In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production.  May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
What are the official names of this protein?
C-type lectin domain family 4 member A, C-type lectin superfamily member 6, Dendritic cell inhibitory receptor.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein; Extracellular side.
Protein: METK_STRP6
Sequence: MSERKLFTSESVSEGHPDKIADQISDAILDAILAEDPEAHVAAETCVYTGSVHVFGEISTTAYIDINRVVRDTIAEIGYTEAEYGFSAESVGVHPSLVEQSGDIAQGVNEALESREGDTDDLSHIGAGDQGLMFGFAINETPELMPLPISLSHQLVRRLAELRKSGEISYLRPDAKSQVTVEYDEHDKPVRVDTVVISTQHDPEATNNQIRQDVIEKVIKAVIPADYLDDDTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFSGKDATKVDRSASYAARYIAKNLVAAGLATKAEVQLAYAIGVAQPVSVRVDTFGTSTVPEAVLEAAVRQVFDLRPAGIIQMLDLKRPIYKQTAAYGHMGRTDIDLPWERLNKVDALVEAVKTVL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APC5A_XENLA
Sequence: MAKNTVSARFRKVDVDEYDENKFVDEEEAGEGQQGPDEGEVDSAIRGGNMMGALQAALKNPPINTKNQSAKDRAENLVLKVLISFKANEIEKAVQSLDKNSTDLLMKYIYKGFESPSDNSSAVLLQWHEKALAVAGVGSIVRVLTARKTV
What is the function of this protein?
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911).  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 5-A.
What is the protein family that this protein belongs to?
Belongs to the ARPC5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein: SOX9_PIG
Sequence: MNLLDPFMKMTDEQEKGLSGAPSPTMSEGSRGSPCPSGSGSDTENTRPQENTFPKGEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPAGAGHVWMSKQQAPPPPPHPPQQPPPVPQAPAQPQAALPQQPQAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSGSYYSHARSQGSVLYSTFTYMNPAHGPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP
What is the function of this protein?
Transcription factor that plays a key role in chondrocytes differentiation and skeletal development.  Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6.  Also binds to some promoter regions.  Plays a central role in successive steps of chondrocyte differentiation.  Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes.  Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis.  Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression.  Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C.  Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation.  Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes.  Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors.  In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix.  Controls epithelial branching during kidney development.
What are the official names of this protein?
Transcription factor SOX-9.
What are the subcellular locations of this protein?
Nucleus.
Protein: CHS3_PEA
Sequence: MVSVSEIRKAQRAEGPATILAIGTANPANCVEQSTYPDFYFRITNSEHKTELKQKFQRMCDKSMINRRYMYLTEEILKENPSVCEYMAPSLDARQDMVVVEVPRLGKEAAVKAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPYVKRYMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEVTAVTFRGPSDTHLDSLVGQALFGDGAAALIVGSDPLPEIENPIFEMVWTAQTIAPDSEGAIDGHLREAGLTFHLLKDVPAIVSKNIDKALVEAFQPLGISDYNSIFWIAHPGGPAILDQVEQKLALKPEKMKATREVLSEYGNMSSACVLFILDEMRRKSIQNGLKTTGEGLEWGVLFGFGPGLTIETVVLHSVAI
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase 3, Naregenin-chalcone synthase 3.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: PHOSP_SENDF
Sequence: MDQDAFILKEDSEVEREAPGGRESLSDVIGFLDAVLSSEPTDIGGDRSWLHNTINTPQGPGSAHRAKSEGEGEVSTPSTQDNRSGEESRVSGRTSKPEAEAHAGNLDKQNIHRAFGGRTGTNSVSQDLGDGGDSGILENPPNERGYPRSGIEDENREMAAHPDKRGEDQAEGLPEEVRGGTSLPDEGEGGASNNGRSMEPGSSHSARVTGVLVIPSPELEEAVLRRNKRRPTNSGSKPLTPATVPGTRSPPLNRYNSTGSPPGKPPSTQDEHINSGDTPAVRVKDRKPPIGTRSVSDCPANGRPIHPGLETDSTKKGIGENTSSMKEMATLLTSLGVIQSAQEFESSRDASYVFARRALKSANYAEMTFNVCGLILSAEKSSARKVDENKQLLKQIQESVESFRDIYKRFSEYQKEQNSLLMSNLSTLHIITDRGGKTDNTDSLTRSPSVFAKSKENKTKATRFDPSMETLEDMKYKPDLIREDEFRDEIRNPLYQERDTEPRASNASRLLPSKEKPTMHSLRLVIESSPLSRAEKAAYVKSLSKCKTDQEVKAVMELVEEDIESLTN
What is the function of this protein?
Acts as a chaperone for newly synthesized free N protein, so-called N(0).  Stabilizes the L protein upon binding it.
What are the official names of this protein?
Phosphoprotein, Protein P.
What is the protein family that this protein belongs to?
Belongs to the respirovirus P protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: HNF1A_SALSA
Sequence: MEGEERKGEAGPGPGRLSALQEQLIWALLGSGLSREVLVHALGELERERVTPGAEKGDRGDGESSEEGEMDFPPPIFQELEALAPEEAARQRALVDQLLQEDPWRVAKLVKSYMQQHNLPQREVVESIGLNQSHLSQHLNKGTPMKNQKRAALYSWYVRKQGEISQQFTNARHALGSGEEQGEDVRKGRRNRFKWGPASQQILFHAYERQRNPSKEEREGLVEECNRAECLQRGVSPSQLAGLGSNLVTEVRVYNWFANRRKEEAFRHKLALDMPYNSQSASSTNHTLSHSPEQGMKYSQQITCDNLGSSRGHNGDRGLGGRLASPIQLEPSHTLLETHHHKPVSGGGPLPPVSTLTSLHSLSASPAPHHGLIMTSLPSVMSLGESSLLIGQTVPVINNVGGGFTTLQPISFQQQLHSTSQQQLTQQFQSHMGHHHSPFMATMAQLPCHMYSKSDMSHYPPSSLLSQAMVITDSSSLGTLTSLTTVRQILTTDPEEQTDQPIQEDSLHLQSPSPVPVSSGNLQLYPPSQSSESHPPHRLSSSPADINSYIPAQMVSTAQ
What is the function of this protein?
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreas and liver (By similarity).  Binds to the promoter of the albumin gene.
What are the official names of this protein?
Hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, Transcription factor 1, TCF-1, sHNF1.
What is the protein family that this protein belongs to?
Belongs to the HNF1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS8_PELTS
Sequence: MYTEFDAAALARADLKALTPYEAPYYPEVVKLDANENPYGFPPEVLTAILSEVGSREFSRYPDAAAGRLRESLAGYTGVDPENIMVGNGADELILNIMLTFGTGAKFAIATPTFSMYGIHGRIASCEKVEVPRLDGFRVDVEAMKRAAGEPGVKIAVICTPNNPTGNATPPEEIEEILKSTGAIVVVDEAYAEFGGRSCIPLLNRYPNLVILRTFSKAFALAGLRVGYLLAGRPVINELLKVKQPYNLNAFSQAAARVVMENLPPFKERIKKILEERERLFTELSALPGVEAFPSQANFILFRTPMPAGEVYGGLLERGVLVRNVDGPGLSRCLRVAVGTAEENRLFIEKLGEVLGRPA
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: STMN1_GEKJA
Sequence: MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD
What is the function of this protein?
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules.  Prevents assembly and promotes disassembly of microtubules (By similarity).
What are the official names of this protein?
Stathmin.
What is the protein family that this protein belongs to?
Belongs to the stathmin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RHBG_BOVIN
Sequence: MAWSPRHSAGRRLQLPLLCLLLQGATAILFAVFVRYNRETDAALWHWGNHSNADNEFYFRYPSFQDVHAMIFVGFGFLMVFLQRYGFGSVGFTFLLAAFALQWSTLIQGFFHSFRGGYILVGMESMINADFCAGAVLISFGAVLGKTGPVQLLLMALLEVVLFGLNEFVLLSLLEVKDAGGSMTIHTFGAYFGLILSRVLYRPQLEKSKHRQGSVYHSDLFAMIGTIFLWIFWPSFNSAPTALGDGQHRTALNTYYSLTASTLSTFALSALVGGDGRLDMVHVQNAALAGGVVVGTSAEMMLTPFGALAAGFLAGAISTLGYKFVTPILESKLKVQDTCGVHNLHGMPGVLGALLGGLVAGLATREAYGDGLESVFPLIAEGQRSATSQAMHQLFGLFVTLTFASVGGGLGGLLLRLPILDSPPDSQCYEDQIYWEVPGEHEHLAQGSEETETQA
What is the function of this protein?
Ammonium transporter involved in the maintenance of acid-base homeostasis.  Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism.  May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (By similarity).  May act as a CO2 channel providing for renal acid secretion (By similarity).
What are the official names of this protein?
Ammonium transporter Rh type B, Rhesus blood group family type B glycoprotein, Rh family type B glycoprotein, Rh type B glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Protein: AGTR1_RABIT
Sequence: MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
What is the function of this protein?
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney.  The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
What are the official names of this protein?
Type-1 angiotensin II receptor, Angiotensin II type-1 receptor, AT1 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SBNA_STAAB
Sequence: MIEKSQACHDSLLDSVGQTPMVQLHQLFPKHEVFAKLEYMNPGGSMKDRPAKYIIEHGIKHGLITENTHLIESTSGNLGIALAMIAKIKGLKLTCVVDPKISPTNLKIIKSYGVNVEMVEEPDAHGGYLMTRIAKVQELLATIEDAYWINQYANELNWQSHYHGAGTEIVETIKQPIDYFVAPVSTTGSIMGMSRKIKEVHPNVQIVAVDAKGSVIFGDKPINRELPGIGASRVPEILNRSEINQVIHVDDYQSALGCRKLIDYEGIFAGGSTGSIIVAIEQLITSIEEGATIVTILPDRGDRYLDLVYSDTWLEKMKSRQGVKSE
What is the function of this protein?
Catalyzes the synthesis of N-((2S)-2-amino-2-carboxyethyl)-L-glutamate (ACEGA) from O-phospho-L-serine and L-glutamate.  Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics.
What are the official names of this protein?
N-(2-amino-2-carboxyethyl)-L-glutamate synthase, ACEGA synthase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.
Protein: DCTA2_PSEAB
Sequence: MTKQPFYKSLYVQVLVAIAIGIALGHWYPETAVAMKPFGDGFVKLIKMAIAPIIFCTVVTGIAGMQSMKSVGKTGGMALLYFEVVSTVALIIGLVVVNVVQPGAGMHVDPNTLDTSKIAAYAAAGEKQSTVDFLMNVIPGTVVGAFANGDILQVLFFSVLFGYALHRLGSYGKPVFEFIERVSHVMFNIINVIMKVAPIGAFGAMAFTIGAYGVGSLVQLGQLMLCFYITCILFVLIVLGGIARAHGFSILRFIRYIREELLIVLGTSSSESALPRMIDKMEKLGCNKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATDTPMDITHQITLLLVLLIASKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATVVVSKWCKQLDEGTLQRELAGEGNASSPASDIPVGGREAV
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein 2.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS3_LEGPC
Sequence: MGQKVNPIGIRLGIIKDWNSKWFAGKRYAEFLIQDIKLRNDLKKKLMAAAVSKILIERPANNAVVTILTARPGVIIGKKGGGIETLRKEISDNLGVPVHLNIEEVKKPELDATLVAEGIAQQLEQRVMFRRAMKRAVTSALKAGAKGIKICVSGRLGGAEIARSEWYREGRVPLHTFRADIDYGTAESKTTYGIIGVKVWIFKGEILPQKKRSTESAQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: Y1521_ARCFU
Sequence: MEVLFEAKVGDITLKLAQGDITQYPAKAIVNAANKRLEHGGGVAYAIAKACAGDAGLYTEISKKAMREQFGRDYIDHGEVVVTPAMNLEERGIKYVFHTVGPICSGMWSEELKEKLYKAFLGPLEKAEEMGVESIAFPAVSAGIYGCDLEKVVETFLEAVKNFKGSAVKEVALVIYDRKSAEVALKVFERSL
What is the function of this protein?
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712).  Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712).  Catalyzes removal of a phosphate group from ADP-ribose 1''-phosphate (Appr1p), but with low efficiency (PubMed:15902274).
What are the official names of this protein?
ADP-ribose glycohydrolase AF_1521, [Protein ADP-ribosylaspartate] hydrolase AF_1521, [Protein ADP-ribosylglutamate] hydrolase AF_1521.
Protein: RL15E_METKA
Sequence: MDAVSMYKYQREAWKRPKDSYVGELLKERLPKWRKGPSVQRIKRPTRIERARRLGYRAKPGYVVVRVRVPKGGRRKSRPKKGRRPKRMGKNKFSPGKSKQWIAEERAQRKYPNLEVLNSYWVGEDGQYKYYEVIMVDPYHPQIKSDHRINWICQKSQKGRVFRGKTGAGKKARGLRKRGKGAEKVRPSLRAHRRRGK
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: RT11_MOUSE
Sequence: MQVLRNSGSWLLLSWAGHGMTRFVGIAPAKNIHTGAPRLEDSAARQNTEREAAPSRFSLYPPVPGQESSLQWAGMKFEDVPIAHIKATYNNTQIQVVSATNASLARASCGTEGFRNAKKGTGIAAQTAGIAAAAKATGKGVTHIRVVVKGMGPGRWSAIKGLTMGGLEVISITDNTPVPHNGCRPRKARRL
What are the official names of this protein?
28S ribosomal protein S11, mitochondrial, MRP-S11, S11mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Mitochondrion.