PharMolix/UniProtQA huggingface dataset:
Protein: MUTB_PROFR
Sequence: MSTLPRFDSVDLGNAPVPADAARRFEELAAKAGTGEAWETAEQIPVGTLFNEDVYKDMDWLDTYAGIPPFVHGPYATMYAFRPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDNPRVAGDVGMAGVAIDSIYDMRELFAGIPLDQMSVSMTMNGAVLPILALYVVTAEEQGVKPEQLAGTIQNDILKEFMVRNTYIYPPQPSMRIISEIFAYTSANMPKWNSISISGYHMQEAGATADIEMAYTLADGVDYIRAGESVGLNVDQFAPRLSFFWGIGMNFFMEVAKLRAARMLWAKLVHQFGPKNPKSMSLRTHSQTSGWSLTAQDVYNNVVRTCIEAMAATQGHTQSLHTNSLDEAIALPTDFSARIARNTQLFLQQESGTTRVIDPWSGSAYVEELTWDLARKAWGHIQEVEKVGGMAKAIEKGIPKMRIEEAAARTQARIDSGRQPLIGVNKYRLEHEPPLDVLKVDNSTVLAEQKAKLVKLRAERDPEKVKAALDKITWAAGNPDDKDPDRNLLKLCIDAGRAMATVGEMSDALEKVFGRYTAQIRTISGVYSKEVKNTPEVEEARELVEEFEQAEGRRPRILLAKMGQDGHDRGQKVIATAYADLGFDVDVGPLFQTPEETARQAVEADVHVVGVSSLAGGHLTLVPALRKELDKLGRPDILITVGGVIPEQDFDELRKDGAVEIYTPGTVIPESAISLVKKLRASLDA
What is the function of this protein?
Catalyzes the reversible conversion of succinyl-CoA to (R)-methylmalonyl-CoA through a radical mechanism (PubMed:9772164).  Is involved in the fermentation of pyruvate to propanoate that occurs in Propionibacteria (Probable).
What are the official names of this protein?
Methylmalonyl-CoA mutase large subunit, MCM-alpha.
What is the protein family that this protein belongs to?
Belongs to the methylmalonyl-CoA mutase family.
Protein: NUOC_BARHE
Sequence: MSESLEELAAYLKSKLGDKLEETVLAFGELTIVSRLDAITDVLIFVRDDSRCQFINITDISGVDYPCRDKRFDVSYQLLSPRHNLRLRVKVRTDENIPVASACSIYPGAEWYERETYDMYGILFSGHPDLRRILTDYGFEGHPLRKDFPVTGFVECRYDNEAKRVIYEPVVLRQEMRNFDFLSPWEGAQYILPCDEKTKDKR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ILVC_PSEP1
Sequence: MKVFYDKDCDLSIIQGKKVAIIGYGSQGHAQACNLKDSGVDVTVGLRKGSATVAKAEAHGLKVADVATAVAAADLVMILTPDEFQGALYKNEIEPNIKKGATLAFSHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNAKNVALSYASGVGGGRTGIIETTFKDETETDLFGEQAVLCGGTVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGPEVINEESRKAMRNALKRIQDGEYAKMFISEGATNYPSMTAKRRNNAAHGIEIIGEQLRSMMPWISANKIVDKTKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RS18_STRPD
Sequence: MAQQRRGGFKRRKKVDFIAANKIEYVDYKDTELLSRFVSERGKILPRRVTGTSAKNQRKVTTAIKRARVMALMPYVNED
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: DAPF_XANOM
Sequence: MSADGRSGRLRFTKMHGAGNDFVVLDLRDGTPPPDAALAAQLADRHFGVGCDQILTIEAPRSEGAVAAYGIWNSDGSAARQCGNGARCVAAWLVRDGIAQCERFIIDSPVTAHAVERLEGGRYAVAMGMPQFDPPQIPLAGFAHARDEYALPVHGDTVRFGAVSMGNPHAVVEVGRVDAAPVERVGTLLQQNAAFPDSVNVGFVQVVDPTHVRLRVFERGVGETLACGSGACAAAVVLMQRCRVERDVQVSLPGGELRIRWPCDHEQVVMSGPAVFVFDGEWNG
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_GEOSE
Sequence: MAIKKYKPTSNGRRGMTVLDFSEITTDQPEKSLLAPLKKRAGRNNQGKITVRHQGGGHKRQYRIIDFKRDKDGIPGRVATIEYDPNRSANIALINYADGEKRYIIAPKNLKVGMEIMSGPDADIKIGNALPLENIPVGTLVHNIELKPGRGGQLVRAAGTSAQVLGKEGKYVIVRLASGEVRMILGKCRATVGEVGNEQHELVNIGKAGRARWLGIRPTVRGSVMNPVDHPHGGGEGKAPIGRKSPMTPWGKPTLGYKTRKKKNKSDKFIIRRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2, BstL2, L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: SSY2_ARATH
Sequence: MASVAESSFPLLCQIKTQRRINSSTLRHSRVSYHDLPSGSLSFRSRSFVLGHRCKCVSRVEASGSDDDEPEDALQATIDKSKKVLAMQRNLLHQIAERRKLVSSIKESTPDLDDAKASSKQESASSVNANTDATKKEIMDGDANGSVSPSTYGKSSLSKEPEAKTFSPSTESLKNRKQSSASVISSSPVTSPQKPSDVATNGKPWSSVVASSVDPPYKPSSVMTSPEKTSDPVTSPGKPSKSRAGAFWSDPLPSYLTKAPQTSTMKTEKYVEKTPDVASSETNEPGKDEEKPPPLAGANVMNVILVAAECAPFSKTGGLGDVAGALPKSLARRGHRVMVVVPRYAEYAEAKDLGVRKRYKVAGQDMEVMYFHAFIDGVDFVFIDSPEFRHLSNNIYGGNRLDILKRMVLFCKAAVEVPWYVPCGGVCYGDGNLAFIANDWHTALLPVYLKAYYRDHGIMKYTRSVLVIHNIAHQGRGPVDDFSYVDLPSHYLDSFKLYDPVGGEHFNIFAAGLKAADRVLTVSHGYSWEVKTLEGGWGLHNIINENDWKFRGIVNGIDTQEWNPEFDTYLHSDDYTNYSLENLHIGKPQCKAALQKELGLPVRPDVPLIGFIGRLDHQKGVDLIAEAVPWMMSQDVQLVMLGTGRPDLEEVLRQMEHQYRDKARGWVGFSVKTAHRITAGADILLMPSRFEPCGLNQLYAMNYGTIPVVHAVGGLRDTVQQFDPYSETGLGWTFDSAEAGKLIHALGNCLLTYREYKESWEGLQRRGMTQDLSWDNAAEKYEEVLVAAKYHW
What is the function of this protein?
Involved in the synthesis of glycan chains within amylopectin in leaves.  Is required to produce chains with a degree of polymerization of 12 to 25 (DP12-DP25).
What are the official names of this protein?
Starch synthase 2, chloroplastic/amyloplastic, AtSS2, Soluble starch synthase II.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast. Plastid, amyloplast.
Protein: SUB4_TRIVH
Sequence: MVCLKTLSVFLAAFAAADARAVFKTQGHKNSEMIPDNYIVVMKDGVSQDDFKAHISSVASIHSTNKAKRGTNTQGMKREFDIMNWRGYHGHFDRDTLEEILNDSKVDYVEQDQVVRISGLVTQRSAPSWGLGRVSHRQAGSRDYVFDDSAGRGVTIYGVDTGIDINHQDFRGRARWGTNTADRDNADRHGHGTHTASTFAGTAYGIAKNANIVAVKVLGSDGSGSTSGIIAGINYCVQDAQQRGILGKAAMNLSLGGGFSQANNDAVTRAQNAGIFVAVAAGNDNRDARNYSPASAPAVCTVASSTINDSKSSFSNWGPVVDIYAPGSDIIAARPGGGSTTMSGTSMASPHVAGMGAYMIGMGADPRQVCDRLKQLATAAIRNPGSSTTNRLLYNGSGQ
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: METK_STAAC
Sequence: MLNNKRLFTSESVTEGHPDKIADQVSDAILDAILKDDPNARVACETTVTTGMALIAGEISTTTYVDIPKVVRETIKEIGYTRAKYGYDYETMAILTAIDEQSPDIAQGVDKALEYRDKDSEEEIEATGAGDQGLMFGYATNETETYMPLAIYLSHQLAKRLSDVRKDGTLNYLRPDGKVQVTVEYDENDNPVRIDTIVVSTQHAEDVTLEQIQEDIKAHVIYPTVPENLINEQTKFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGCFSGKDPTKVDRSAAYAARYVAKNIVAAGLADQCEVQLAYAIGVAEPVSIAIDTFGTGKVSEGQLVEAVRKHFDLRPAGIIKMLDLKQPIYKQTAAYGHFGRTDVLFPWEKLDKVEELKDAVK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21A_NOSS1
Sequence: MTQIVVGENEHIESALRRFKREVSKAGIFQDMRKHRHFETPIEKSKRKKLALHKQSKRRFRT
What are the official names of this protein?
30S ribosomal protein S21 A.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: Y1746_ERWT9
Sequence: MFDLTLAIMLFLAALSYFSHNITVTIALLVLIVIRMTPLQQTFPWIEKQGMTVGIIILTIGVMAPIASGTIPSSTLMHSFLHWKSLTAIAIGIFVSWLGGRGVTLMSTQPTVVGGLLIGTIIGVSLFRGVPVGPLIAAGLLSLMLGKG
What are the official names of this protein?
UPF0756 membrane protein ETA_17460.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: A63F_DROME
Sequence: MKAIIVFILFISSVHAMSKCNQAIYLNLDPHCGILPDCNLDGPNPSYLKRVSCERKENGKPGFIELIPGKCLHGKPRCSLK
What is the function of this protein?
Responsible for physiological and behavioral changes in mated female flies.
What are the official names of this protein?
Accessory gland protein Acp63F.
What are the subcellular locations of this protein?
Secreted.
Protein: FMTA_STAAW
Sequence: MKFNKVKLVIHACVLLFIIISIALIFHRLQTKTHSIDPIHKETKLSDNEKYLVDRNKEKVAPSKLKEVYNSKDPKYKKIDKYLQSSLFNGSVAIYENGKLKMSKGYGYQDFEKGIKNTPNTMFLIGSAQKFSTGLLLKQLEEEHKININDPVSKYLPWFKTSKPIPLKDLMLHQSGLYKYKSSKDYKNLDQAVKAIQKRGIDPKKYKKHMYNDGNYLVLAKVIEEVTGKSYAENYYTKIGDPLKLQHTAFYDEQPFKKYLAKGYAYNSTGLSFLRPNILDQYYGAGNLYMTPTDMGKLITQIQQYKLFSPKITNPLLHEFGTKQYPDEYRYGFYAKPTLNRLNGGFFGQVFTVYYNDKYVVVLALNVKGNNEVRIKHIYNDILKQNKPYNTKGVIVQ
What is the function of this protein?
Catalyzes the liberation of D-alanyl moieties present on wall teichoic acid (WTA) and lipoteichoic acid (LTA).  Affects the methicillin resistance level and autolysis in the presence of Triton X-100 as well as the cell wall structure.
What are the official names of this protein?
Teichoic acid D-alanine hydrolase, Teichoic acid D-alanine esterase.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NAGB_PHOLL
Sequence: MRLIPLANASDVGKWSAHYIVSKINAFNPTAEHPFILGLPTGSTPLATYKELIALHKAGKVSFKYVVTFNMDEYVGITENHPQSYHHFMHQNFLDHIDIPKENINLLNGNASDVETECQRYEDKIKSYGQIHLFMGGVGNDGHIAFNEPASSLTSRTRIKTLTVETRTANSRFFDNDINQVPKYALTVGVGTLMDAEEIMILATGLNKAQAIQAAIEGNVNHMWTISCLQMHPKSIIVCDEPATMELKVKTVKYFHQLEADIIGEFASKK
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: TRPA_BUCBP
Sequence: MNNRYYQLNKNLIPYKLGCYIPFVVLGDPSIEISLEIIYSLIKNGADGLELGIPFSDPLADGPIIQQANLRAFSANITLTKCFEMLFKIRTHNPKIPIGILIYANLIFKLGIQKFYSICSKIDIDSVLIADVPIEESFEFEQHSIKNNIDSIFVCPPDASKNFLKKLSKHSTGYIYLLSRSGVTGIDMKITPPLKNFVKELKKLTSIPIIQGFGISNENQIKNIILSGVSGVICGSVIIQIIANNLNNKKIMLKKIKKLSNRFKKATII
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: MIAA_ALKMQ
Sequence: MKKKILMLVGPTAVGKTETSIALCQRLKGEIISADSMQLYRHMNIGTAKPSLEEQQGIPHHLIDIIEPDASFTVADFQSEAARLIDAITKRNKFPIVAGGTGLYINSLLYDMDFTSAVSNWNLRQKLQKDAQLYGNEYVYKKLQDIDPNAATKIHPNNVKRVIRALEVNYESGENFGDFKNDIEKNTCYEPLLIGLTRDRSELYERINYRVDQMIETGLIEEVKNLLDCGYTPELIAFKGLGYKEIIAYLEGQYDLEEAITILKRDTRRYAKRQLTWFNRYQEIQWYNLTDQSSSNIIEAILKNVEGYFNLS
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ZIPA_CROS8
Sequence: MMQDLRLILIIVGAIAIIALLVHGLWTSRKERSSMFRDRPMKRMKSKRDEDEDEDDVDEPDDDGVGEVRVRRSAPAPESAPARQPQHNYQPPYAPSQPRQPVREPVEPEPEVAYREAPQAPLHQPQEPQPVRQTAPQPSQPAPAQPAMRQPAPQPVTEPAPQPEPVAEPVPVSAPEKPQPKETVIIMNVAAHAGSQLNGDVLFNSIQQAGFKFGDMNIFHRHLSPDGSGPVLFSLANMVKPGSFDPESMTDFTTPGITIFMQVPGFGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDRIRDVKEANG
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: REP_CACV
Sequence: MAPVRAAAAKRWCFTLNNYTAEEEAKVRALLPGEFHFAICGKERGEQGTPHLQGFLHFKKKQRLSALKKLLARAHWEKARGSDHDNEEYCSKENDVILTIGEPVQGNRSDLAGAVAAVKAGRRMVDIAREFSEIYVKYGRGLRDLALMIGQKPRDFKTEVVVITGPSGVGKSRLASEMEGSKFYKMKGDWWDGYSNEDIVIMDDFYGWLPFCEMLRLMDRYPHKVPVKGSYVEFTSKKIVITSNTHPESWYCPDKCYLPALFRRINKWMYWDGLRFEDVPDAMKKHPINY
What is the function of this protein?
Essential for the replication of viral ssDNA.  The closed circular ssDNA genome is first converted to a superhelical dsDNA.  Rep and/or Rep' binds a specific hairpin at the genome origin of replication.  Introduces an endonucleolytic nick within the conserved sequence 5'-AGTATTAC-3' in the intergenic region of the genome, thereby initiating the rolling circle replication (RCR).  Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester.  The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase.  The polymerase synthesizes the (+) strand DNA by rolling circle mechanism.  After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication.  Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.  ATPase activity is probably carried by the isoform Rep (By similarity).
What are the official names of this protein?
Replication-associated protein, ATP-dependent helicase Rep, RepP.
What is the protein family that this protein belongs to?
Belongs to the nanoviruses/circoviruses replication-associated protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: HSLU_FRATM
Sequence: MTQIMTPKTIVHELERHIIGQNDAKKAVAIALRNRWRRMQLDNEMRQEVTPKNILMIGPTGVGKTEIARRLAKLADAPFIKVEATKFTEVGYVGKDVESIIRDLVETAVKMKREEAKEKVTEKAARLAEDRILDVLIPPARTSESKVGFANEPAEDAASKKEKENKTREIFRKKIQNGELDDKEIEIEVAVAPKTIGVMGPPGMEDMTSQLQDLFSSLSTDKKKNKKMRIKDAIKLAQDEEAAKLVNEEDIKARALEAVEQNGIVFLDEIDKVCRKSSNSGADVSREGVQRDLLPLVEGSTVSTKYGVIKTDHILFIASGAFHVAKPSDLIPELQGRLPIRVELKSLEIEDFVRILREPDCSILKQYIALMKTEGIDLSFEEDAIRKIAEIAYKVNEEVENIGARRLHTVMERLLEKISFDAPELVEKNINITTDYVNEKLGNLVKNKDLSQYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRAM1_MOUSE
Sequence: MAIRKKSNKNPPLLSHEFLLQNHADIVSCLAMLFLLGLMFEVTAKGAIIFVALQYNVTRPATEEQATESASLYHYGIKDLATVLFYMLVAIIIHAIIQEYVLDKINRRMHFSKTKHSKFNESGQLSAFYLFACVWGTFILISENYISDPTILWRAYPHNLMTFQTKFFYISQLAYWLHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSAFQAPPVKRKPAVTKGRSSRKGTENGVNGTVTSNGADSPRNRKEKSS
What is the function of this protein?
Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel.  Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER.  May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport.  Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane.  Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane.  Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome.
What are the official names of this protein?
Translocating chain-associated membrane protein 1, Protein TRAM1.
What is the protein family that this protein belongs to?
Belongs to the TRAM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: M3K10_MOUSE
Sequence: MEEEEGAAAREWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPAAPAAPSDLQLPQEIPFHELQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMSQLSQEKPRVRKRKGNFKRSRLLKLREGSSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPMDCGGSSGSGTWSRSGPPKKEELVGGKKKGRTWGPSSTLQKERAGGEERLKALGEGSKQWSSSAPNLGKSPKHTPMAPGFASLNEMEEFAEADEGNNVPPSPYSTPSYLKVPLPAEPSPCVQAPWEPPAVTPSRPGHGARRRCDLALLSCATLLSAVGLGADVAEARAGDGEEQRRWLDSLFFPRPGRFPRGLSPTGRPGGRREDTAPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPLAPSPSTNPLVDVELESFKKDPRQSLTPTHVTAAHAVSRGHRRTPSDGALRQREPLELTNHGPRDPLDFPRLPDPQALFPTRRRPLEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLSISPPSRPDTPESPGPPSVQPTLLDMDMEGQSQDNTVPLCGVYGSH
What is the function of this protein?
Activates the JUN N-terminal pathway.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 10.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein: PEPT_LACLM
Sequence: MKYEKLLPRFLEYVKVNTRSDENSTTTPSTQALVEFAHKMGEDMKALGLKDVHYLESNGYVIGTIPANTDKKVRKIGLLAHLDTADFNAEGVNPQILENYDGESVIQLGDTEFTLDPKDFPNLKNYKGQTLVHTDGTTLLGSDDKSGVAEIMTLADYLLNINPDFEHGEIRVGFGPDEEIGVGADKFDVADFDVDFAYTVDGGPLGELQYETFSAAGAVIEFQGKNVHPGTAKNMMVNALQLAIDYHNALPEFDRPEKTEGREGFFHLLKLDGTPEEARAQYIIRDHEEGKFNERKALMQEIADKMNAELGQNRVKPVIKDQYYNMAQIIEKDMSIIDIAKKAMENLDIAPIIEPIRGGTDGSKISFMGLPTPNLFAGGENMHGRFEFVSVQTMEKAVDTLLEIIRLNNEVAK
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.  Has a broad specificity for tripeptides with no clear preference for a particular tripeptide.  Tripeptides with proline in the second position are an exception and are not hydrolyzed.  Does not hydrolyze dipeptides, tetrapeptides, or oligopeptides (By similarity).
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_BACSU
Sequence: MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDEKFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGGGTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPETCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKINVTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTFAQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVTPTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFC1_YEAST
Sequence: MPVEEPLATLSSIPDSSADQAPPLIADEFTLDLPRIPSLELPLNVSTKHSSIQKAIKMCGGIEKVKEAFKEHGPIESQHGLQLYLNDDTDSDGSKSYFNEHPVIGKRVPFRDESVILKVTMPKGTLSKNNNSVKDSIKSLKDSNKLRVTPVSIVDNTIKFREMSDFQIKLDNVPSAREFKSSFGSLEWNNFKSFVNSVPDNDSQPQENIGNLILDRSVKIPSTDFQLPPPPKLSMVGFPLLYKYKANPFAKKKKNGVTEVKGTYIKNYQLFVHDLSDKTVIPSQAHEQVLYDFEVAKKTKVYPGTKSDSKFYESLEECLKILRELFARRPIWVKRHLDGIVPKKIHHTMKIALALISYRFTMGPWRNTYIKFGIDPRSSVEYAQYQTEYFKIERKLLSSPIVKKNVPKPPPLVFESDTPGGIDSRFKFDGKRIPWYLMLQIDLLIGEPNIAEVFHNVEYLDKANELTGWFKELDLVKIRRIVKYELGCMVQGNYEYNKYKLKYFKTMLFVKESMVPENKNSEEGMGVNTNKDADGDINMDAGSQMSSNAIEEDKGIAAGDDFDDNGAITEEPDDAALENEEMDTDQNLKVPASIDDDVDDVDADEEEQESFDVKTASFQDIINKIAKLDPKTAETMKSELKGFVDEVDL
What is the function of this protein?
TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements.  Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function.  Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes.  Participates in the interconnection of tauA with tauB via its contacts with TFC3 and TFC6.  Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability.
What are the official names of this protein?
Transcription factor tau 95 kDa subunit, TFIIIC 95 kDa subunit, Transcription factor C subunit 1.
What is the protein family that this protein belongs to?
Belongs to the TFIIIC subunit 5 family.
What are the subcellular locations of this protein?
Nucleus.