PharMolix/UniProtQA huggingface dataset:
Protein: SPB4_LODEL
Sequence: MQTNKGSLLWENLRVDLEPWLKDAIRSLNYPTMTPVQASTIPLLSGNKDVIVEAVTGSGKTLAFAIPVLQKVSKRLYQVPEGEEKPEPVKRGHMLAIVMAPTRELAKQIQMVFDKVLELLPEEDSYEPRIKTQLLVGFLGNVREDLDSYQENRPQILIATPGRLLDFMSLQIVKTSSLEIVILDEADKLLDMSFETDVIKILKMLPKQRRTGLFSATISAAGDTIFRTGMNNPVKLQVKTKNFLGEQNNAPTSLQLSYMMIEPEHKLTTMLQMLRDNQFKKAIVYFPTCTSVKHFYQMLSKLCKSSANDIDISALLFFSLHGQLTTKSRLNTLEKFTEGNDESKKYILMATDVAARGIDIPDVDLVIQIDPPTDPSVFLHRCGRTGRANKVGRAIVMLNNDTQEEDYVGFMEVKSVFMTKIDPPEDKDNHSFHNKFQKKLRKYMLEDRARHELAVKSYVGFVRYYSKHIASLIFRLASLDYIAIAKMYGLLRLPKMPESRYIENEKMPEDGWLGEVVDMDTYAYLDKSAEKARLENLEKDKLAKAENAKRRKELKVKNEAWSSKTEKRETKLERKEKMKRKREAIEKQLEAEQERGGLDEEEVKEDWKDLVRKNKKKQKSNGGGGGGGVLQGSFDDL
What is the function of this protein?
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.  Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA.  Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5. 8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
What are the official names of this protein?
ATP-dependent rRNA helicase SPB4.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GLR31_ORYSJ
Sequence: MKFIFYLFSIFCCLCSCAQSQNISGRPDAVRIGAQFARNSTIGRVAAVAVLAAVNDINNDSNILPGTKLDLHMHDSSCNRFLGIVQALQFMEKDTVAIIGPLSSTTAHVLSHLANELHVPLMSFSATDPTLSSLEYPFFVRTTVSDQFQMTAVADLVEYYGWKQVTTIFVDNDYGRNAISSLGDELSKRRSKILYKAPFRPGASNNEIADVLIKVAMMESRVIILHANPDSGLVVFQQALKLGMVSNGYAWIATDWLTSYLDPSVHLDIGLLSTMQGVLTLRHHTENTRRKSMLSSKWSELLKEDSGHSRFLLSTYGLYAYDTVWMLAHALDAFFNSGGNISFSPDPKLNEISGRGLNLEALSVFDGGQLLLEKIHQVDFLGATGPVKFDSGGNLIQPAYDIVSIIGSGLRTVGYWSNYSGLSVISPETLYKKPANRTRETQKLHDVIWPGETINKPRGWVFPNNGNEIKIGVPDRVSYRQFVSVDSETGMVRGLCIDVFVAAINLLAYPVPYRFVPFGNNRENPSYSELINKIITDDFDAVVGDVTIITNRTKVVDFTQPYVSSGLVVLTSVKRQNSGGWAFLQPFTIKMWTVTGLFFLIIGTVVWMLEHRINDEFRGPPAKQLITVFWFSFSTLFFAHREDTRSTLGRFVIIIWLFVVLIIQSSYTASLTSILTVQQLTSPITGIDSLITSDVPIGFQVGSFAENYLAQELGVAHSRLKALGSPEEYKKALDLGPSKGGVAAIVDERPYIELFLYQNPKFAVVGSEFTKSGWGFAFPRDSPLSVDLSTAILELSENGDLQRIHDKWLASDMSSMSQASELDQDPDRLDVYSFSALFLICGLACIFALAIHACNLFYQYSRHAAEEDPAALQPSASDGSRSLSRRSKLQSFLSFADRREADIRRAAKEKASGLGGSGGSMSGVSFTSSGSGSTTASC
What is the function of this protein?
Glutamate-gated receptor that probably acts as non-selective cation channel.  Involved in root development.  May regulate cell proliferation and cell death in the root apex.
What are the official names of this protein?
Glutamate receptor 3.1, Ligand-gated ion channel 3.1.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PSRP_CROS8
Sequence: MDNVVDRQVFYISDGTAITAEVLGHAVMSQFPVSINSITLPFVENESRARAVKEQIDAIYQQTGVRPLVFYSIVLPEVREIILQSQGFCQDIVQALVAPLQEELRLDPSPVAHRTHGLNPANLNKYDARIAAIDYTLAHDDGISMRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLNLPAALRPFQHKLFGLTINPERLAAIREERRENSRYASMRQCRMEVAEVEALYRKHQIRYINSTNYSVEEIATKILDIMGLNRRMY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: RF2_RICCN
Sequence: MRAEIENYVKKIEQSLELLWRSLDVEASTERLNALEELTADPSLWNDQANAQKLLREKSNLEEKLNAFNKLKSNLKDALELEEMAEAENDLETLSQIEQDLKNLSIIAAKFETECLFSGEADGNNCFLEINAGAGGTESHDWASIMMRMYLRFAERLGFKTEIINMINGEEAGIKSCTIRIIGKRAYGWFKTETGVHRLVRISPFNAAGKRMTSFASSWVYPEIDDNIAITIEDKDLRIDTFRASGAGGQHVNTTDSAVRITHIPTGTVTQCQSDRSQHKNKAQAMKMLQAKLYELEMQKRTDSVNEQNAAKTDNSWGHQIRSYVLQPYHMVKDLRTDYETSDTKGVLDGDLEEFVSAHLAMNVGGKK
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_PASMU
Sequence: MTDFQFYLASNSPRRAQILQQLGFRFALCCCEIDETPLPDEKGADYVLRMAIEKNNAARQQWQQAKFSQNRPHLPFLSADTSVILEDKILGKPKNEADARAMLRALSARTHQVITAVCVADENQMQTVIQTSHVRFKVLTEKEIQGYIATGEPMDKAGAYGIQQLGGVFVEHIEGSFSGVMGLPVCETVALLKAFGVELF
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APCF_CYAPA
Sequence: MKDAITSLIATYDVTGKYFDDNAVDTLNAYFSTASARIESVKIINANVSTIIKTAASALFDEQPELIAPGGNANTTRRYAACLRDIDYYLRYATYAIISADVDVLDERVLDGLKETYNSLGVSIAPTVRAIELLKNTSKELIKAAGISAVDFIDEPFDYMGKVLADSSL
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex.  Allophycocyanin has a maximum absorption at approximately 650 nanometers.
What are the official names of this protein?
Allophycocyanin subunit beta-18, Allophycocyanin subunit B18.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Plastid, cyanelle thylakoid membrane; Peripheral membrane protein; Stromal side. Note=Forms the core of the phycobilisome.
Protein: HPRT_METV3
Sequence: MKKVLDETLESSPIIKRGEYNYFIHPIADGVPLFTSDLLRDVATRTIQRIDTNIDKIVTAEAMGIPIATAISMSTDIPYVVMRKRQYFLEGEVPVHQETGYSKGELYLNGVEKGDRVTIVDDVLSTGGTLIAVIKALEKAGAEIVDIVCVIERGDGKSKVKEITGYDVQTLVKIDVTENGVVILESN
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
What are the official names of this protein?
Hypoxanthine/guanine phosphoribosyltransferase, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GDAP2_RAT
Sequence: MDPLGAPSQFVDVDTLVSWGDSYEDEVNSSDSTAEAFQEDSNRSPFLYNRDINGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLKGCRTGEAKLTKGFNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGETIEKVVFAISELEEATYQKLLPLYFPRSLKEESQSLPSLPADIGNAEGEPVVPERQIRISEKPGASEDHEEDEDEGLGVDLSFIGSHAFARMEGDIDKQRKLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSEYNHLDSDFLKKLYDVVDIKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLQQLFSAISPEQIDFPPFVLEYDARENGPYFASYPPSPDL
What are the official names of this protein?
Ganglioside-induced differentiation-associated-protein 2.
What is the protein family that this protein belongs to?
Belongs to the GDAP2 family.
Protein: NU6M_HALGR
Sequence: MMTYIVFILSIIFVISFVGFSSKPSPIYGGLVLIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPEVWVSNKAVLGAFVMGLLSELLLACYILKDDEVDAVFEFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSLFIGVLVIMEVTRGN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: XGCA_NEOFI
Sequence: MKFWLQQLGLAVLCASSAAARTAEHAYEFKSVAITGGGYITGIVGHPAEKNLLYARTDIGSTYRWEQELNKWIPLTDFLGPEDENLLGTESVAMDPTDPNRLYLAQGRYLSSNNSAFFVSNDRGATFTRYRAPFPMGANELGRNNGERLAVNPFKPNELWMGTRNAGLMKSSDRAKTWTNVTNFPDAAANGIGITFVIFDPQHEGTIYVGACIPGGLYYTTDGGKNWESIPGQPMQWDPSLLVYPNETQPQSAGPQPMKAVLASNGALYVTYADYPGPWGVAYGAVHVYNTTASIWTDITPNANNTSPKPYTPQAFPAGGYCGLSVAPDDPDTVVVVSLDRDPGPALDSMYLSRDGGKTWKDVSQLSTPPGSGGYWGHPIAEAALSNGTTVPWLSFNWGPQWGGYGAPSPVKGLTKFGWWMTAVLIDPSNPDHVLYGTGATIWATDTIAQADKNLAPKWYIQAQGIEETVTLAMISPREGAHLLSGAGDINGFRHDDLDTPQPMFGLPVFSNLNTLDWAGQRPEVIVRGGPCGHQYPDGCGQAAYSTDGGSEWTKFQTCIKGVNTSVHNPGVMTIDASGKYVVWTSAMYVVSPSVQAVTPPANDSGPYASSDWGKTWTSPRGLTVQTPYISADRVQPKTFYAFSGGVWYVSTDGGLSYDAFNATKLGLPAHTGAVPVVSVDRAGEIWLALGSNGVYHTTDFGKRWKRITHKGTVADLITVGAAAPGSTKPALFIRGSPGHPKKSDYGIYRSDDNGSTWDRVDDDDHRYGGFNLIQGDPRVYGRVYLGTGGRGLLYADIVPGQSDKEGNVPGTGGI
What is the function of this protein?
Oligoxyloglucan-reducing end-specific xyloglucanase involved in degradation of xyloglucans.  Releases the first two glycosyl segments from oligoxyloglucans.  Active against cotton xyloglucan, tamarind xyloglucan and tamarind xyloglucan oligomers.
What are the official names of this protein?
Probable oligoxyloglucan-reducing end-specific xyloglucanase, OREX.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 74 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS11_BURP1
Sequence: MAKASNTAAQRVRKKVKKNVAEGVVHVHASFNNTIITITDRQGNALAWATSGGQGFKGSRKSTPFAAQVAAESAGRVAMEYGVKNLEVRIKGPGPGRESAVRALHGLGIKITAISDVTPIPHNGCRPPKRRRI
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RS2_YERPP
Sequence: MATVSMRDMLQAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELTKISSRKGKILFVGTKRAASEAVKEAANNCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLEIQSQDGTFDKLTKKEALMRTRELNKLENSLGGIKDMGGLPDALFVVDADHEHIAIKEANNLGIPVFSIVDTNSDPDGVDFIIPGNDDAIRAVKLYLGAVATAVREGRSQDLAVQAEESFVEAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: HTPG_RICCN
Sequence: MIQEKKKFDAEVGKILNLMIHSLYSNKEIFMRELISNASDACDKLRYLSQSNSELVAGDSNFKITVKVDKDHRQIIIRDNGIGMNKDDLIENLGTIARSGTANFLKSLSGDSKKDNMLIGQFGVGFYSSFMVADKVTVTSRKAGEDKVHIWESDGLGEYTVSDSDKEFTRGTEIVLHIKKEEDTFLDHFRLKHIVKSYSDHIAVPIYFFDEAGNNEIQLNSASALWTRPKSEITEEQYKEFYKSLSYAIDDPWITMHNKNEGAIEFTNLLFIPSSKTFDLFHPDRKRRVKLYIKRVFISDENIDLIPSYLRFLRGVVDSEDLPLNISRESLQHNSVLEKIKNAITKRVLGELRKKKEESPEEYNKFWANFGGALKEGLCEATTNHEKLLEVCIFRSALHNKMISLDEYIANFKEGQSTIYYLSGDNPDKLLSSPQIEGLLSKKIDVLLFTDTVDDFWVNVNSKYKEHAIKSATRSDIDVEQTTSQSEEKNTDSTKSNDEYKLLTDYFKETLGELVKEVKISKKLTSSPACLAVSDAAMDIRMERFLIEQKQIANASAKNLELNPKNKIIEKIFNDLKANNKNNEELVNLIFDQACILEGEPVADTGAFSKRLNDIVQKAIL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORF1_MBVLF
Sequence: MNNVEISRDECKAMSHGLYCRVASDAQLQRAGWLVQFAVVPRKGQKQLAANWPFYLVLHRALRNGPEFVGFLLFAAREIEQIRTRLGSGFRKTLVVGNDHFNKYIKYNGKTIVWCDVLCGTVVPKDSSHCPDVGLETLVPGTVLSGSQFATLSQNIGMALRGNCRCHLRDVCMVHQEVS
What are the official names of this protein?
Uncharacterized protein ORF1.
Protein: PSRP_SHEWM
Sequence: MLRKVFYISDGTAITAEVFGHAVLSQFPVEFEALTIPFVETESKANEVKAQINDCFITTGERPLVFHSIVKAEIRDIIYSSEGLDYDFLNTFVAPLEQQLGISATPVVHRTHGNMNESYEARIDAINYAMDNDDGQTLKHIDKADLVLLGVSRCGKTPSSLYLSMQFGIKAANYPFVEDDMDNLKLPDALKKNKSKLFGLTIDPVRLHEIRQSRMENSRYSSLRQCRIEVKEVEMMYKRERIPFVNTTNHSVEEIATKILAMTGLERHMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: APDD_EMENI
Sequence: MWSILSIKRSTSRMELMCLNAAECPINVFPEQQRNMPTESLNPGTVLIVGGGPVGLITATTLAKYGVRSVILERNLTTTKWPKMDLTNSRSMEIYQRLGIADALRNVAVPSHYPFTCLFSSGLHADKAITAWDLPSPDEYRRRIREQNDGSMPSEPWLRVSQEIFEAWLKELGMENPLIDFRAGWKVKGARELDHGVEVEAIHSDTGEVWKVSADFVIGCDGAHSAIRKSLEIPLDGGPIHGYAVLVHFKSRDLSRIQKQGQFWHLFFPNAASDGGSIKGAVIAQDEVDTWTVHRFMRPDVDHTQLSSEEIVYDLLGGMGGQPFPIRIDEVLVRSTWTPSVALARSYAGPKHRIFIAGDACHQTVPTGGYGMNTGIADGYDIGWKLAAVIQGWAGPATLLSYEKERRPVGELALQWSKVHMGNLMKMSAELGLDAHMIELNNETGAELRGAMHSYLQTHDGHNQSIGVEMGYRYVSNICVPGALDAELSPPEFHPRKYTPCTMPGYRAPHVYLTTGTPVSRLFGDGFTLVAFPEGEGLNASTEQLREAARKKALPLEVVELPGEMHAHEVWGASLVLVRPDGFVSWHGDSVRSQEEADRIIAQASGFDSEHLGNHVQAQERSAL
What is the function of this protein?
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of aspyridones (PubMed:17369821, Ref. 5).  The polyketide-amino acid backbone preaspyridone A is first assembled by the PKS-NRPS hybrid apdA (PubMed:17369821, PubMed:20828130).  The assembly of preaspyridone A is initiated by loading of malonyl-CoA onto apdA, followed by decarboxylation to yield the acetyl starter unit (PubMed:20828130).  The growing polyketide chain then elongates into a tetraketide (PubMed:20828130).  The adpA PKS module catalyzes three Claisen condensations, as well as beta-keto processing and methylation (PubMed:17369821, PubMed:20828130).  Alpha-methylation step during polyketide synthesis is a prerequisite and a key checkpoint for chain transfer between PKS and NRPS modules (PubMed:25494235).  The downstream NRPS module contains the condensation (C), adenylation (A), and thiolation (T) domains and catalyzes the incorporation of tyrosine via the formation of the L-tyrosinyl-thioester and the amide linkage between L-tyrosinyl-thioester and the tetraketide (PubMed:20828130).  The bimodular assembly line is terminated with a reductase (R) domain that facilitates formation and release of the tetramic acid product (PubMed:20828130).  Because apdA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase apdC (PubMed:17369821, PubMed:20828130, Ref. 5).  ApdC appears to operate with different stereoselectivity in different PKS cycle (Ref. 5).  Combined with apdC, apdA is proposed to synthesize preaspyridone A via about 20 enzymatic steps (PubMed:20828130).  A number of oxidative steps performed successively by the cytochrome P450 monooxygenases apdE and apdB are required for the conversion of preaspyridone A to aspyridone A (PubMed:17369821).  The cytochrome P450 monooxygenase apdE is responsible for the oxidative dephenylation of preaspyridone A (Ref. 5).  Finally, the predicted FAD-dependent monooxygenase apdD and the acyl-CoA dehydrogenase apdG may be involved in the transformation of aspyridone A into aspyridone B (PubMed:17369821) (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase apdD, Aspyridones biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: RL3_METM7
Sequence: MGMKKSRPRRGSLAFSPRKRAKKLVPKIRSWPADKKVGLQAFPVYKAGTTHALLIENNPKSPNNGQEVFTPVTVLETPDVTVAGIRLYEKTTKGLKALTEVWAEQLDNDLGRKLTLVKKEEKKTADALDAVLEKATEVRVIVHTNPKTTGIPKKKPEVVEIRIGGSSVAERLAYAKEILGKTLAISDVFEAGEIIDTLAITKGKGFQGSVKRWGIKVQFGKHQRKGVGRHTGSIGPWRPRRVMWTVPLPGQMGFHQRTEYNKRILKLGSEGAEITPKGGFLNYGAVKNGYVVVKGTVQGPAKRLVVLRGSVRAAEDKFGLPEVAYISTESKQGN
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ERFD_KLULA
Sequence: MVSLVLADTADSSDLSKAAITVEESTSAQQPKFFNYHEFVITKYRALDEESCEEHGPENPICITHFPNIYVPEESDEFRTTRVVRIPRRFESSTEFPNFSTQLPGSEPAALPDTHNKEFVPAGEFEGQWYGETSVSPLSNYLDQAEWTEIVTRINSLLEAAYNPITRRNFVNVILDLLTLNLWSIIEPYLFVNPLQSVEDYVSEINRSESFRLKGIKIIPPRESSYLSVCIDSPAWIKPCTAINEPLLTHCDTLIVLL
What is the function of this protein?
The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.  Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity).
What are the official names of this protein?
Ras modification protein ERF4.
What is the protein family that this protein belongs to?
Belongs to the ERF4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: YR618_MIMIV
Sequence: MKIENIEINIGIFGNVSVGKSSLVNCILGKKLSEIGYSKTTFVPQAYTNFGNREYHLESIRHLNEMANDQAKTINSTDKIKHVMHYIDKFSLLEDSRNGINDKIDSMFKIIIWDMPGFDTTHHGNMYLDWLSTNIKIFDIIVYVTEIMDDNLTMFDMLVSYVRKYDIKMICVVNKCDNMKLDKDSSVISLGTIDHDNRYIKINNTMANYATQYSIGNNNYITPFLPISVQNYEYFGNNLLLKNCDNDFGFEIFIASIINAINNHKLYFAVKHINRHIKVSKSKSMIDIIEYSRIVRKCNAQSRFIDISSGYNLSKYNLSENFWNLIRDTITSHASKIVQKCVKVVNDGKNIGFRSFDDVNIDIQVFLSFVNSVEIFKDFDDYPNDLVEYYRIKVISNLLNIYDVIADFEYTNQHYLDISNIFLYLELIKEHMRTEFDNYALKFIYTHRNIKTFESHYQESLINILKFIADNLSCCLSRNKFTSIVCMILINKQLYMKNKNNYLQYIISVKKLIKSVIKPTITINYIGPLDILIETTKKNVSIAISDNRLSSFYKQDINMFTVNNQLNNFYLGDTFDISVDFEKKLLELVKFE
What are the official names of this protein?
Uncharacterized protein R618.
Protein: GAB1_MOUSE
Sequence: MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEDMNKWVRCICDICGFNPTEEDPVKPLTGSSQAPVDSPFAISTAPASSQMEASSVALPPPYQVISLPPHPDTLGLQDDPQDYLLLINCQSKKPEPNRTLFDSAKPTFSETDCNDNVPSHQTPASSQSKHGMNGFFQQQMMYDCPPSRLTSVSGESSLYNLPRSYSHDVLPKESPSSTEADGELYTFNTPSGTAGVETQMRHVSISYDIPPTPGNTYQIPRTFPESTLGQSSKLDTIPDIPPPRPPKPHPTHDRSPVETCGVPRTASDTDSSYCIPPPAGMTPSRSNTISTVDLNKLRKDASSQDCYDIPRTFPSDRSSSLEGFHSQYKIKSVLTAGGVSGEELDENYVPMNPNSPPRQHSGSFTEPIQEPNYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLDIKPLSEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSGEDPNLFASNSLDGGSSPMNKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSMADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPTKNVK
What is the function of this protein?
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases.  Plays a role in FGFR1 signaling.  Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).  Involved in the MET/HGF-signaling pathway.
What are the official names of this protein?
GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the GAB family.
Protein: BLRF2_EBVA8
Sequence: MSAPRKVRLPSVKAVDMSMEDMAARLARLESENKALKQQVLRGGACASSTSVPSAPVPPPEPLTARQREVMITQATGRLASQAMKKIEDKVRKSVDGVTTRNEMENILQNLTLRIQVSMLGAKGQPSPGEGTRPRESNDPNATRRARSRSRGREAKKVQISD
What is the function of this protein?
Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA (PubMed:26320998).  Acts by inhibiting CGAS-DNA phase separation: directly binds double-stranded DNA (dsDNA) in a length dependent but sequence independent manner and is able to form DNA-induced phase separation in infected cells.  DNA phase separation of ORF52 mediates disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (By similarity).
What are the official names of this protein?
Tegument protein BLRF2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae BLRF2 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm.
Protein: ATG2_CRYNB
Sequence: MFSLPSFLTTFSFTLPSLPSISLPANIQRRFLSYVLKRTLGRFVSHQALDAERIQAQVSEGWVEIENLEIECSEINNYIPPPLPLSLTSGTINKLTAKLPFPNLWSDPLQVSLDTLTLDFTLSSPSPLSRGRAATRPEHHDLAESVTSAADDFLHHELDAYEEKELEGSIRQSLILSQTDPFISDVPGGFPLGSPGEISPGRPLPANMESTTVLAGMVERILARLEFRVEKIKIRLVIEDEEDVVELTVGRIRYADESEAQTNDDGKSTTRAIRISNISLDIVPSQRKPPSLVIPQRQSLEPSVSSSTSTASTSSGNDYSDMFMSQAVVDLRQSLLTPEQISEPANEQTVHESNMFYSALSQPNESEPGASTGIKRSGISQNPKLADEIEEERSRSETPTPETKPQPSGIPVLSFGQEDVVLHMRTTRPLISAGHQTSFNDNKPTVEMNITIGTITTVLLPSHLKLFISALQTLQALCQKDDVPAAKDKPAQSTSPQTRLTATTKLKAFYVSLVYDLSAETSLNLHSTMASHLTRPTNPIPYPHLRFRLDTLVASYQSPGHSNPSRPAFTRPTPNMSTANLRRKSSGHARFGSLPSNLTVNVGDISLFEWMGEGMIAPVILFDPGLKHQYDLPSAPPHKGQAGFPECECRDWREEKKTGSEKAWRVRPRGRGILKGGARATTEDEGPVVHVRQDLGSDSAAVINLQSLHVFVDLSLIERLLPLLRSVTPLIHPPEPTPAWLQSVPSQSISEEITPESIISSLSAPPPTARGKKMKADIRCDLVRLSVRCPAPPPEPAERQIGDGRQLRSGIVFVDVHGLKSRFMDTSRTGTRPASSEVANVEFEQTLIFFASVSQHYAYPFLIFAPLSPEPGEEDIPLLPSISLSSFPQASSLPASSIAKTTLVTCKMPAIRASVHHPTVTGLQYFADDVTRWLDVAFADGSAKPRDELKMIGSRFFGGSKGSEASSEIDEPYDVEEVAAGMKVEIEISEIDMGLYVPRLDASGERVFSFKANDLGVRMETHPEENETALELSIMDLDFSDVSSTPLRILGRTTPFTLTSHQAPVVYLRFVSSTDLRTTLKESNISVALSHFTFAVHKEIAWLHEIAQFAKPPKGVFENLSPTDLTRLSINLSSASFLLVPPNLPGSIVILVREVEGKTEIPKGATDSVLEVGMSGLGALAVEGESGPLEVSSDLADVWKKAGYAQLAEVMVLELRLMRELVAAGEVSLDITQAQFKVTACADSLATFAEIATDFGHSLDENAFNLLPEIVSHSDTDMIEDDLPHNLDYLDHATRISKHYPSMDRTTGENLRAWHTPEEGLEEGEWENGESGETIRAFGGEIEEEEGYWEGLPILNDVYSADQKPGKIHIRVLDASLKIFLHDGYDWPRTRKAIEDEVRAVRRRLERIRQLLASGQKADESIENATSSVLFNSIYIGLEQKGEMGLSTMGMGKMDEKALMAAIDEELDGMETESGSSWQTLPAGVGAGPSAVHQAHKKTRLKGKRLVRSKKAQIEITLSGIKTDVDLYPTEESTSSRVHFTAKEMEILDHIKTSTWKKFLTEMKADNRGNIRETDADMLRIELVGVRLKEDEEELRLRAKILPLRLHVDQDALDFLKRFFSFKAPPMTSARPLAQHTTSSTPDLYFQHVEIFPIQLKLDYKPKRVDFRALREGKTIELMNFFHFEGAEMTLRHITLSGITGLERLGTTLQDLWTPDVKANQLADVISGVSPIRSMVNVGSGVADLILLPIEQYRKDGRIAKGVQRGTNSFVKSTALEVMKLGARLATGTQVILERAEGVLGGKSGEDVVGQVQGLSTNAFGVDSGMLEGGSSSEDEQEAISRYADQPESMKEGVQAAYKSLSKNVNAAAQTILAVPMEVYERSGDDGPLKAVIRAVPIAVLKPMIGTTEAVSKTLLGMRNSLDPSARRELDDKYK
What is the function of this protein?
Lipid transfer protein required for autophagosome completion and peroxisome degradation.  Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion.  ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region.  The latter binding is assisted by an ATG18-PtdIns3P interaction.  ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
What are the official names of this protein?
Autophagy-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG2 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.