PharMolix/UniProtQA huggingface dataset:
Protein: PTH_RUTMC
Sequence: MTIKLIVGLGNPGKDYQSNRHNAGFWLCEALAHLYAGNFKKETKFFGEVAQINISGRKVRLLKPTVFMNCSGQSIQSIVNFYQINTNEILIVHDELDIDPGIAKIKFDGGHGGHNGLRDTIQTLGTKAFHRLRIGIGHPGDKSQVTNFVLHAPSKGELEKIQNSLNNSLQIIEDMINGNFDKAIKTLHTKE
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HGPRT_STAAS
Sequence: MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
What are the official names of this protein?
Hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTHR_ORYSJ
Sequence: MKVIEKIQEAAADGRTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGSTADLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQDKFVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAYLKQKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTKIPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILMNLGLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLGWDQYPHGRWGDSRNPSYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDINERFMNFCQGKLTSSPWSELDGLQPETKIIDDQLVKINQKGFLTINSQPAVNGERSDSTSVGWGGPGGYVYQKAYLEFFCSKEKLDQLIEKSKAFPSLTYIAVNKDGESFSNIPTNAVNAVTWGVFPGKEIVQPTVVDSASFMVWKDEAFEIWSKGWACLFPEGDSSREILDKVQKSYFLVSLVDNDYINGDLFAAFKEI
What is the function of this protein?
The probable reversibility of the MTHFR reaction in plants suggests that they can metabolize the methyl group of 5,10-methylenetetrahydrofolate to serine, sugars and starch.
What are the official names of this protein?
Probable methylenetetrahydrofolate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the methylenetetrahydrofolate reductase family.
Protein: Y4685_BACAN
Sequence: MNGIRDVVKEEQPRERLLLEGAGSLSNRELLAVLLRTGSKEESVLKLSDKILHHFDGLRMLKDATLEELVSIHGVGVAKATQLIAAFELGRRMVRLEYQNRYSIRSPEDCATYMMEEMRFLQQEHFVCLYLNTKNQVIHRQTIFIGSLNSSIVHPREVFKEAFRRAAASIICLHNHPSGDPAPSREDIEVTKRLVECGRIIGIEVLDHIIIGDHKFVSLKEKGHI
What are the official names of this protein?
UPF0758 protein BA_4685/GBAA_4685/BAS4351.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: BTGE_NEOFI
Sequence: MRGAILATAAALAGTAMADVAHMRRHGHDSFHQRRAAVAEADATCGCTTEVVTVWGPPTLIPVATPTPSTVTSEAVTTLHSTSTSTVTIVASASTPATSSSPATPKVPLPTPAITNFPSTGVYTIPATTVTVFDTTTVCGATTTELPAGTHTYGGVTTVVETATTVVCPYATVEPSGTTVTSVIKTTTYVCPTPGTYTIAPTTTTVPTSTVVVYPTPAVITPGTYTQPEQTVTVTRTDYTYVCPFTGQNEPTSAPAAPSTTAVPATTTAAVPSTSSAAPSSSSTAPASTGAVGGQMGMTYTPYTKGGDCKDKSSVLSEVANLKSKGFTHVRVYSTDCNSLEYIGEAARTSGLQMIIGVFISSTGVSGAQDQVTAISKWAQWDLVSLIVVGNEAIQNGYCDASTLAGFISSAKSAFQSAGYTGKVTTTEPINVWQAYGSTLCGVCDIIGANIHPFFNADVSADQAGKFVAQEIKVLEGICPGKDVLNLETGWPHAGNANGKAVPGASEQAIAIKSIAQEVGSKSVFFSYFDDLWKEPGQFDVERYWGCIDTFN
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase btgE, Beta-D-glucoside glucohydrolase btgE, Cellobiase btgE, Gentiobiase btgE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Covalently-linked to the cell wall.
Protein: BC11A_HUMAN
Sequence: MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDESRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE
What is the function of this protein?
Transcription factor (PubMed:16704730, PubMed:29606353).  Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491).  Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353).  Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765).  Involved in brain development (PubMed:27453576).  May play a role in hematopoiesis (By similarity).  Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity).  May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity).
What are the official names of this protein?
B-cell lymphoma/leukemia 11A, BCL-11A, B-cell CLL/lymphoma 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, EVI-9, Zinc finger protein 856.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). SUBCELLULAR LOCATION: [Isoform 1]: Nucleus matrix. Note=Colocalizes with BCL6 in nuclear paraspeckles. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus in nuclear paraspeckles. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus. Note=Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles.
Protein: SYE_DEHM1
Sequence: MTNEVRVRYAPSPTGYPHLGNIRTAMFNWLFARHNGGKFIVRIEDTDRERYVEGAVESILESLNWLGLDWDEGPDKGGDYGPYYQSERLFLYRQAAERLVTEGKAYYCHCSSERLDKMREEQIARKEPPGYDRCCRDLCLGQKEGAVIRFKIPLEGQTTFIDLIRGEVTFDNAKQDDFVILKSDGFPTYHLASVVDDHAMQISHVLRAEEWLPSTPKHLMLYKALGYTPPQYAHLPMILGPDRSKLSKRHGATSTIEYKQAGYLPETMVNFLSLLGWAYDDKTELFSRKQLIEYFCLEKVSKTAAIFNYEKLDWMNGMYIRTLSAPDLASRAIPFLEKDERIAASGRLNFDYTTKVMPLIQERVKKLSELAELCWFIYSDNISYDPASLIDKKLTKDESLCALKAAFARLEALANFDAVSMEEHIRPLAAELELKPGQLFGMLRTASTGQQVAPPLFQTMEVLGRERCLGRIAMAIARLSELPS
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COGA_PARCM
Sequence: IVGGTEVTPGEIPYQLSLQD
What is the function of this protein?
This enzyme is a serine protease capable of degrading the native triple helix of collagen.
What are the official names of this protein?
Collagenolytic protease 36 kDa A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: PNP4_ALKMQ
Sequence: MIKQFQTELAGKTLHVEIGKYAEQASGSCMVRYGDTTVLVNATASKSPREGIDFFPLSVDYEEKLYAVGKIPGGFIKREARPSEKAVLTSRLIDRPIRPLFPKGYRNEVQVIATVMSVDKDYAPDIVAMIGSSIALSISDIPFGGPTGSVNVGLVNGEFVLNPTSDQRAISDIDLVVSGTKDAIMMIESGANEVTEDQMLDALMFAHEEIKTIVAFIEEIVAEVGKPKQEVQLFAIDETLDMEVRVFAKDKIVTAMKTFDKMERNERLDNVKKEILVHFSKQYENELKSIVEVINSIIKEQFRYMITHDKVRPDERALDEIRPITSEVGILPRTHGTGLFTRGQTQVLTVATLGALGEVQILDGLGEEESKRYMHHYNFPPYSVGEAKFLRGPGRREIGHGALAERALLPMVPSQDDFPYAIRLVSEVLSSNGSSSQASVCGSTLALLDAGVPIKDMVAGIAMGLVKENDKIAILSDIQGMEDALGDMDFKVAGTDKGITAIQMDIKIKGIHKDILKDALEQARVGRLHILDKMKKAIDKPRPELSPFAPRVLKMKIHPDKIRDVIGSGGKTINRIIDETGVKIDIDNDGTIFIAAESQEAVEKAIIIIENIIKDPEVGQNYTGKVIKIMNFGAFLEILPGKEGLLHVSNIAHERVNKVEDVLEVGQEIEVKVMEIDQQGKINLSRKALLPKESKAENTKEEKA
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase 4, Polynucleotide phosphorylase 4, PNPase 4.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOW_STAAS
Sequence: MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLNHYISFLESTPKQVVYERV
What is the function of this protein?
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
What are the official names of this protein?
6-carboxyhexanoate--CoA ligase, Pimeloyl-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the BioW family.
Protein: PG138_VACCC
Sequence: MADKKNLAVRSSYDDYIETVNKITPQLKNLLAQIGGDAAVKGGNNNLNSQTDVTAGACDTKSKSSKCITCKPKSKSSSSSTSTSKGSKNTSGAPRRRTTVTTTSYNAMDGQIVQAVTNAGKIVYGTVRDGQLEVRGMVGEINHDLLGIDSVNAGKKKPSKKMPTNKKINMSSGMRRQEQINPDDCCLDMGMY
What is the function of this protein?
Component of the virion core that undergoes proteolytic processing during the immature virion (IV) to mature virion (MV) transition.  Essential for the formation of a structurally normal core.
What are the official names of this protein?
25 kDa core protein OPG138.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG138 family.
Protein: ZNT6_XENTR
Sequence: MGTIYLFRKTQRSLLGKLTQEFRLVTADRRSWKILLFGAINVVCTGFLLTWCSSTNSMALTAYTYLTIFDLFSLITCLISYWVMMKKPSPTYSFGFERFEVLSVFASTVLAQLGALFILKESAERFVEQPEIHTGRLLVGTFVALCFNLFSMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGIIPGLSSIFLPRMNPFVLIDIAGALALCITYMLIEINNYFAVDTASAIAIAVMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLLREVSTLDGVLEVRNEHFWTLGFGTMAGSVHVRIRRDANEQMVLAHVTNRLNTLVSSLTVQIFKDEWARPVLASGAMPPNMLNIPDHHVIQMPSLKSTMDELNPMTSTPSKPSSPPPEFAFNTPGKNMNPVILSNNQTRPSGVGFNYGTTPYTTTFNHGLGVPGIGNTQGLRTGLTNVANRYGTYTPGQFTQFKQ
What is the function of this protein?
Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway.  As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
What are the official names of this protein?
Zinc transporter 6, ZnT-6, Solute carrier family 30 member 6.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles.
Protein: CSRA_SHEB2
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQSEKSGTPSEGGNF
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_CHLTE
Sequence: MRIEALNTAPDATEARFEEQIRPQKMGDFAGQKKLIDNLKVFITAARKRGEALDHVLLSGPPGLGKTTLAHIIAAEMGGSIKITSGPLIDKAGNLAGLLTSMKKGDILFIDEIHRLAPAVEEYLYSAMEDYRIDILLDSGPASRAVQLKLEPFTLVGATTRAGLLTSPLRARFGINSRLDYYNPELLQSIIIRAAGILNIGIDEDAAMEIARRSRGTPRIANRLLRRARDFAQVAGDASISLAVARRTLESLEIDEGGLDDMDKKILEAIVRKFNGGPVGLASLAVSVGEEQDTIEEVYEPYLIQMGYLSRTPRGRVATRLAMSRFAHPGISSQGSLFDTAEDG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: FEOC_YERPS
Sequence: MASLLQLRDAIALNGSAEASQLSRQLAIPLPLVNAMLEKLTAMGKIERIELDHSGCLTGSCKSCPEGHQHCNTVIYQLKEPHAHQ
What is the function of this protein?
May function as a transcriptional regulator that controls feoABC expression.
What are the official names of this protein?
Probable [Fe-S]-dependent transcriptional repressor.
What is the protein family that this protein belongs to?
Belongs to the FeoC family.
Protein: FPG_NEIG1
Sequence: MPELPEVETTLRGIAPHIEGKTVEAVILRQLKLRWQINPDLGEILSGRQVLSCGRRAKYLIVRFQTGILLIHLGMSGSLRIFTPSDGRIGRPDRHDHVDIVFSDGTVMRYRDPRKFGAILWYEGIEERHPLLEKLGPEPLSEAFCTDYLYAGLKAQKRAVKLALMDNTVVVGVGNIYANESLFRAGISPHRPANRLKKKECAVLVETVKAVLQRAIETGGSTLRDFVDSDGKSGYFQQEYTVYGRHNQPCLRCGGLVVKETLGQRGTFYCTNCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: WLS_DROVI
Sequence: MSGTILENLSGRKLSILVSSLMLCQVACFLMGGLYAPVPAGHQTVVGIKCRDVPGRQNDTNFFLYSRGNGACKSLQDMDIEQDPLKMANQLVYVFQMPLPRDNRTLDYSRWQQNLIGVLQVDIAYDSSSELREPPKELQLTIDTRLAYRNKKDADTDWKLYAHSVEQRYLDCHAAHVGLLETLYTCDIIPLFELGALHHNFYLLNLRFPIDTPKRMNLQFGHMHDLTLTAIHQNGGFTQVWLLLKTLLFPFVVGIMIWFWRRVHILQRSPALLEYMLLYLGGALSFLNLPLEYLTLSIEMPYMLLLSDVRQGIFYAMLLSFWLVFAGEHMLIQDTPNKSTIRSRYWKHLSAVVVGCISLFVFDICERGVQLRNPFYSIWTTPLGAKVAMSFIVLAGVSAAIYFLFLCFMVWKVFKDIGDKRTSLPSMSQARRLHYEGLIYRFKFLMLATLLCAGLTVAGFIMGQMAEGHWKWNEDIEIQLTSAFLTGVYGMWNIYIFALIILYAPSHKQWPTMRHSDETTQSNENIVASAASEEIEFSNLPSDSNPSEISSLTSFTRKVAFD
What is the function of this protein?
A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells.  In non-neuronal cells wls directs wg secretion.  The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26).  In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles.  Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip (By similarity).
What are the official names of this protein?
Protein wntless.
What is the protein family that this protein belongs to?
Belongs to the wntless family.
What are the subcellular locations of this protein?
Presynaptic cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=In non-neuronal cells, wls binds to wg in the Golgi and accompanies it to the plasma membrane where the two proteins dissociate. Wg is secreted and wls is then internalized and returns to the Golgi apparatus in a retromer-dependent manner. Wls and wg colocalize in the Golgi apparatus in wg-producing cells, and reduced expression is seen in non-producing cells. Endoplasmic reticulum expression is unchanged in wg-producing versus non-producing cells. In neuronal cells, wls is localized both pre- and postsynaptically and is transferred trans-synaptically from the pre- to the postsynaptic compartment (By similarity).
Protein: PLT4_ARATH
Sequence: MMKNLPEVGNGGGSGFPAVSVGNKKNKYQRMDSDAEESQNHREAEARNSRTRKYVMACAFFASLNNVLLGYDVGVMSGAVLFIQQDLKITEVQTEVLIGSLSIISLFGSLAGGRTSDSIGRKWTMALAALVFQTGAAVMAVAPSFEVLMIGRTLAGIGIGLGVMIAPVYIAEISPTVARGFFTSFPEIFINLGILLGYVSNYAFSGLSVHISWRIMLAVGILPSVFIGFALCVIPESPRWLVMKGRVDSAREVLMKTNERDDEAEERLAEIQLAAAHTEGSEDRPVWRELLSPSPVVRKMLIVGFGIQCFQQITGIDATVYYSPEILKEAGIQDETKLLAATVAVGVTKTVFILFATFLIDSVGRKPLLYVSTIGMTLCLFCLSFTLTFLGQGTLGITLALLFVCGNVAFFSIGMGPVCWVLTSEIFPLRLRAQASALGAVGNRVCSGLVAMSFLSVSRAITVGGTFFVFSLVSALSVIFVYVLVPETSGKSLEQIELMFQGGLERKDGEVELGDAERLVRKEQEF
What is the function of this protein?
Plasma membrane sugar-proton symporter.
What are the official names of this protein?
Probable polyol transporter 4.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: OL502_MOUSE
Sequence: MAFLEDGNHTAVTGFILLGLTDDPVLRVVLFVIILCIYLVTVSGNLSTILLIRVSSQLHHPMYFFLSHLASADIGYSSSVTPNMLVNFLVERNTISYLGCGIQLGSAVFFGTVECFLLAAMAYDRFIAICSPLLYSNKMSTQVCVQLLVGSYIGGFLNASSFTLSFFSLVFCGPNRVNHFFCDFAPLVKLSCSDVSVPAVVPSFTAGSIIIVTIFVIAVSYIYILITILKMRSTEGRQKAFSTCTSHLTAVTLFYGTITFIYVMPKSSYSTDQNKVVSVFYMVVVPMLNPLIYSLRNKEIKGALKRQLAKNTFS
What is the function of this protein?
Potential odorant receptor.
What are the official names of this protein?
Olfactory receptor 502, Olfactory receptor 204-8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OSTF1_MONAL
Sequence: MSKPPPKPAKPGQVKVFRALFTFDPRTPDELYFEEGDILYISDTSDTNWWKGTCRGRTGLIPSNYVAEQAETIDHPMHEAAKRGNLSWLRECVENKVGINGLDKAGNTALYWACHGGHKDVVELLLNQPSVELNQQNKLGDTVLHAAAWKGYSDIVEMLLDKNARTDIRNNENKLALEMATNAQCASLLKRKQGTNVTRTLSNAEEYLDDDDSD
What is the function of this protein?
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
What are the official names of this protein?
Osteoclast-stimulating factor 1, Osteoclast-stimulating factor-like.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_PROM3
Sequence: MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLDLDHDRVVWDVGHQAYPHKLITGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSISAALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAGHMPNTPFLVVLNDNDMSISPPVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGAVFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLITGKALPSKGKKPPSYSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVPEQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAFDQLIHDVGIQNLPVTFVMDRAGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSGEGVPLLDEGWEPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGVKATVINARFLRPLDQALIHPLARRIGRVVTMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDHASPQQSREALGLTPTQMSERIQEHFCLNSQPSLVGQEAPQALST
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: FAR12_KARBI
Sequence: SPALDDEHNDNFLRL
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
Extended FMRFamide-12, FMRFa-12.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRF amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ANMY1_MOUSE
Sequence: MKLGYGEFSWPTGEAYHGQFYRDHFHGLGTYTWPDGSSFTGTFYLSQREGYGTMHTKTMLFQGLYKEDQRFGPGIETYPDGSQDVGLWFREYLLKLCTRVPSGFSLVNYPEFLAFLTKSRRRLDLSDEKVELGLSEEQDPFFYDYKQYLLNDELKLPPEMHVYSTDNSHLPMTDSLRQELDDHIFMNEIPPFIEDEEPWLITNETPLLVKIQKQTYKFRNKDAHTSWNIPAILEGNRSRFGPSGPKEQISKKMIMKAEEGDYNWIFGILRDNLACADVADSKGYTVLAAAAMHSHLDIVNLLLDFGADVNKRSDEGITPLSMCFLQYYPCKSFHPNIAERTLLQESPKSLVTPKISFLLADANIDYLYDVGMPIAGGDELKTSSLDDSLASMQTPESSNMLHKEEVSPVKTVSTDVEKESEGAAENVDASTLYSVDTNFESTKCLRNYTINVSRDIMEKSAQAYSSLPQHPCFPYKGTVRKMAQSMVERRNRWMTITLLLRRGADPNLCQVPMQALFLAVKAGDVEGVRLLLMSGAQTDIQFPPQLQSLTPLHIAVSLPGEEGVKITELLLHVITNVDAKAADEDYVYKGGKADLLPSSLKLNNEPGPPKSFYSTHTFIPEEGGRTALHVACEREDNKKCARDIVRLLLSHRANPNVLWSGHSPLSLAIASGNDLVVKELLSQGADPNLPLTKGLGTALCVVCDLVYEQQRSVENKIALIDRLISYGADVLNPVTLVQGDRTAVGTAVDYGYFKFFQDRKIAHCPFHALMPAEREVFMARKRLLEYLGLQLRLAVLSKESRLDTKALYLSKRAELAPCHRLKKKGSSSVRTQSSEKQSIPFYKFCYQCGRSIGVRLSPCPRCYGILTCSKYCKTKAWIEFHKKDCNDIMAMIPHLEGSAWRVAESP
What are the official names of this protein?
Ankyrin repeat and MYND domain-containing protein 1.