PharMolix/UniProtQA huggingface dataset:
Protein: BIOH_XANOR
Sequence: MHIDVIGHGPALVLLHGWALHGGVFAPLVERLAPHYQLHLVDLPGHGFSRDDSTPLALPYVVAEIAAATPPAVWLGWSLGGLFALHAAATLPQVRGLAMIAATPRFVRGSDWPDAVQRELFVQFGTELSRDYRGTLERFLALDTLGSAHARSELRSLRETLTARGEPAPEALQQGLSLLERTDLRRALPQLARPSLWIAGQRDRLVPAAGMHAAAALSPHAQALTIAGGGHAPFLGHADQVSEALQRFVASVP
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERPA_SALHS
Sequence: MSDDVALPLQFTDAAANKVKSLIADEDNPNLKLRVYITGGGCSGFQYGFTFDDQVNEGDMTIEKQGVGLVVDPMSLQYLVGGSVDYTEGLEGSRFIVTNPNAKSTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: RL5_SUBDO
Sequence: MPFVKVIKNKAYFKRYQVKFRRRREGKTDYRARKRLVVQDKNKYNTPKYRIVIRFTNTDIICQIIYAKIEGDKVLVSAYAHELPRYGVKVGLTNYAAAYCTGLLLARRLLTNLGLADKYAGQTDIDGEDFNVEHMGDGPRPFRAFLDVGLTRTTTGNRVFAAMKGAVDGGIDIPHSPSRFVGYDEESSQLEADKLRQYIFGGHVSDYMKYLQEEDEEKYKAHFSRFIKEGITADSMEQMYRDAHAKIRANPAHEKKQPRDGLVKKRWNRAKMSLKQKRDRVKQKKAAYLKTLE
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NDP_MACFA
Sequence: MRKHVLAASFSMLSLLVIMGDTDSKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS
What is the function of this protein?
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor.  Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs.  Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1).  May be involved in a pathway that regulates neural cell differentiation and proliferation.  Possible role in neuroectodermal cell-cell interaction (By similarity).
What are the official names of this protein?
Norrin, Norrie disease protein homolog.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOD_SYNFM
Sequence: MPKRFLAPVTEQIYTLNLGPQHPSTHGVLRVLLDLDGEFIVKADPVIGYGHRGHEKMGENRLFKQFLPNTSRLDYLSGFLFNHGYVLAVEKLAGIPVPPRAQFIRTICSEFNRIASHLLWFGTYVMDLGGFTPFLYAFDDRERILDILDWVTGSRLTYSYCRFGGVDRDIDTRFTDMARDFIKRLRSRWPDYHNLVTRNIIFIHRTRGVGVITPEQARQFGVTGPNLRACGIAFDTRKAEPYEVYDQFDFEIPVGSDGDALDRYRVRFEEMEQSLRIIEQALDRLPGGPFMNDSVPTRLKPPKGEVYFAFESARGQAAYYLVSDGTPSPYRCHIRVPSFGNLHVLTEVLRGTLVADAISILGSVDLVIPEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TRM82_PHANO
Sequence: MAFPYQCLVARSESSADGAAWTLFGASGSKIVVQSSNGVASVWSRQAVQVLDPKDDDTQEPPGKRIKLSTPKEQKFNFSSLVLSNNGHYLVGVTGEDKCVRVFQIDAQSGLQQLSERCMSRRPSAITLTSDDSTILCADKFGDVYALPLLPSPEDEQVEAPAPALPLEEKDFTPSATVFTVHSGRNRRTLEEQLKQKAKGPAKPKEAITFRHDLLLGHVSMLTDLAFAKIGNKSYIITADRDEHIRISRGVPQAHIIEGFCFGHEEFVSRLCVTRSGLLVSGGGDAHLLVWDWRNFLLNEKLPLRDTVIKHLRSRPDLSSSFKDDASFKTAVSGIWEVPGIKETSEVLVACEGLPGLFNFNVGTGAVNGDSLSLMGNPLDVAFVQTSPNSWTTIVSIDNVHKAGSTSELRENADGARLQYFSKQVDGAWREDAEMGALVSSFALGGTDGPDLTTADDKAVRDILYHVENLRKRPGAED
What is the function of this protein?
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.  In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82, Transfer RNA methyltransferase 82.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL333_BACC1
Sequence: MRVNITLACTECGDRNYISKKNKRNNPERIELKKYCPRLKRVTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: ENGB_CAMJD
Sequence: MIISAKFITSLVVKFDENLSSNFSEVAFLGRSNVGKSSLINSLCKQKNLAKSSATPGKTQLINFFEVTCKRNEEKFNINFIDLPGFGYAKVSKNLKEIWNQNLDEFLKFRTSIKLFIHLIDSRHTHLEIDVNLNDYLKRFLRPDQKILKVFTKCDKLNQSEKARLKNEFKDSILVSNLNKFGLDSLEDVIINQTLGFDK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: MUTS_SHESR
Sequence: MNPIDTDDLEKHTPMMRQYLTMKAEHHDMLLFYRMGDFYELFYDDAKRASELLGISLTARGKSGGDPIPMAGIPYHAVEGYLAKLVQIGQSVAICEQIGDPATSKGPVERKVVRIVTPGTLTDEALLQERQDNLLAAVYQGKVGFGYATLDVSSGRFVIAELETKESLEAELQRTNPVEILYSEDFDAMELLHHFKGKRRRPEWEFDYDTSIKLLLAQFGTKDLHGFGITDARLSLQAAGCLMQYVKDTQRTALPHINAITRFNQTDTIVLDAATRRNLELTQNLSGGRDNTLAAVLDNTATAMGSRMLQRWIHQPLRDHAQIFARQTAVNELLETTAHESLHEQLKALGDIERIMARLALRTARPRDFARLRQALNLLPQLQQSLAQLSAPHTVKLGQLLGEFPEEQQLLERAIVDNPPMLIRDGGVIREGYNAELDEWRGLSEGATDYLVQLEAREKERTGIATLKVGYNRVHGYYIEVSRLQSQQVPLNYQRRQTLKNMERYITPELKEYEEKVLSSQGKALALEKQLWDELFDLILPKLHELQAFARAAAELDVLSNFAERAETLGYTCPELSSEIGVKIEAGRHPVVERVSQTPFIANPVTLHNQRRMLIVTGPNMGGKSTYMRQVALITLMAHIGCFVSADRAIIGPIDRIFTRIGASDDLASGRSTFMVEMTETANILHNATAQSLVLMDEIGRGTSTYDGLSLAWSAAEYLAQQIGAMTLFATHYFELTQLPELMAGVYNVHLDAIEHEDTIAFMHAVQEGAASKSYGLQVASLAGVPARVIKAAKHKLHQLESRDHQVEGVNVNGTRAPIQTLLALPEPVENPAVSKLKAINPDNLTPKQALDLLYELKRLS
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RS13_BACC0
Sequence: MARIAGVDIPRDKRVVISLTYVFGIGRTTAEKILAEAGISEETRVRDLTEDELGRIRDIIDRIKVEGDLRREVSLNIKRLMEIGSYRGLRHRRGLPVRGQNSKNNARTRKGPRRTVANKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: YL146_YEAST
Sequence: MDTEEKKKTTASVEHARMLQNEIQQLFAQLRDTNSQIRCDLNEFEQIKESSTTADSTTNSAN
What are the official names of this protein?
Coiled-coil domain-containing protein YLR146W-A.
Protein: CD5L_MOUSE
Sequence: MAPLFNLMLAILSIFVGSCFSESPTKVQLVGGAHRCEGRVEVEHNGQWGTVCDDGWDRRDVAVVCRELNCGAVIQTPRGASYQPPASEQRVLIQGVDCNGTEDTLAQCELNYDVFDCSHEEDAGAQCENPDSDLLFIPEDVRLVDGPGHCQGRVEVLHQSQWSTVCKAGWNLQVSKVVCRQLGCGRALLTYGSCNKNTQGKGPIWMGKMSCSGQEANLRSCLLSRLENNCTHGEDTWMECEDPFELKLVGGDTPCSGRLEVLHKGSWGSVCDDNWGEKEDQVVCKQLGCGKSLHPSPKTRKIYGPGAGRIWLDDVNCSGKEQSLEFCRHRLWGYHDCTHKEDVEVICTDFDV
What is the function of this protein?
Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis (PubMed:26048980).  Able to inhibit lipid droplet size in adipocytes (PubMed:20519120, PubMed:22579686).  Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA) (PubMed:20519120).  CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease (PubMed:21730133).  Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC) (PubMed:22579686, PubMed:26607793).  Acts as a key regulator of metabolic switch in T-helper Th17 cells (PubMed:26607794, PubMed:26607793).  Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation (PubMed:26607793).  CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes (PubMed:26607793).  Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (PubMed:23562157).  Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:9892623, PubMed:16054063).  Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (By similarity).
What are the official names of this protein?
CD5 antigen-like, Apoptosis inhibitor expressed by macrophages, mAIM, Apoptosis inhibitory 6, SP-alpha.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Secreted by macrophages and circulates in the blood (PubMed:20519120). Transported in the cytoplasm via CD36-mediated endocytosis (PubMed:20519120).
Protein: Y469_STRGC
Sequence: MKKIFDTTFTIKEVVATGIGAALFVVIGMVSIPTPVPNTSIQLQYAVQALFGVVFGPIVGFLTGFIGHALKDSIQYGNPWWTWVLASGLFGLVVGLLKNYLRVAQGVFESRDIITFNVAQFVANALVWVVIAPLGDILIYNEPSNKVFAQGVVATVANGLTVAVAGTLLLIAYARTQTKSGSLKKD
What are the official names of this protein?
UPF0397 protein SGO_0469.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FAAH1_HUMAN
Sequence: MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
What is the function of this protein?
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788).  Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445).  It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984).  FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
What are the official names of this protein?
Fatty-acid amide hydrolase 1, Anandamide amidohydrolase 1, Fatty acid ester hydrolase, Oleamide hydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the amidase family.
What are the subcellular locations of this protein?
Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
Protein: RPOE_SALTI
Sequence: MSEQLTDQVLVERVQKGDQKAFNLLVVRYQHKVASLVSRYVPSGDVPDVVQESFIKAYRALDSFRGDSAFYTWLYRIAVNTAKNYLVAQGRRPPSSDVDAIEAENFESGGALKEISNPENLMLSEELRQIVFRTIESLPEDLRMAITLRELDGLSYEEIAAIMDCPVGTVRSRIFRAREAIDNKVQPLIRR
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released.  Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as acid stress, heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment (By similarity).
What are the official names of this protein?
ECF RNA polymerase sigma-E factor, RNA polymerase sigma-E factor, Sigma-24.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. ECF subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associates with the inner membrane via RseA.
Protein: INS_RABIT
Sequence: MASLAALLPLLALLVLCRLDPAQAFVNQHLCGSHLVEALYLVCGERGFFYTPKSRREVEELQVGQAELGGGPGAGGLQPSALELALQKRGIVEQCCTSICSLYQLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PNP_STAEQ
Sequence: MSQEKKVFKTEWAGRSLTIETGQLAKQANGAVLVRYGDTVVLSTATASKEPRDGDFFPLTVNYEEKMYAAGKIPGGFKKREGRPGDEATLTARLIDRPIRPLFPKGYRHDVQIMNIVLSADPDCSPEMAAMIGSSMALSVSDIPFQGPIAGVNVGYIDGKYVINPSVADKEISRLDLEVAGHKDAVNMVEAGASEITESEMLEAIFFGHEEIKRLVAFQQEIIDHIQPIKQEFVPVERDEDLVEKVKSLTEDKGLKDTVLTFDKQQRDENLDALKEEVVGHFLDEEDPENETLVKEVYAILNDLIKEEVRRLIADEKIRPDGRKVDEIRPLESEVGLLPRAHGSGLFTRGQTQALSVLTLGALGDYQLIDGLGPEVEKRFMHHYNFPNFSVGETGPVRAPGRREIGHGALGERALRYIIPDTQDFPYTIRIVSEVLESNGSSSQASICGSTLALMDAGVPIKAPVAGIAMGLVTRDDSYTILTDIQGMEDALGDMDFKVAGTKDGITAIQMDIKIDGLTREVIEEALEQARQGRLAIMDHMLHTIEQPREELSAYAPKVVTMSINPDKIRDVIGPGGKKINEIIDETGVKLDIEQDGTIFIGAVDQAMINRAKEIIEDITREAEVGQVYHAKVKRIEKYGAFVELFPGKDALLHISQISQERINKVEDVLKIGDTIEVKITEIDKQGRVNASHKVLEQSKN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_COXBN
Sequence: MARIALGIRYDGSAYHGWQVQEALKTVQGEVEKALSAVANHPVFVTCAGRTDAGVHASAQVAHFDTTAYRSDHAWVFGANSNLPHDISILWAKAVEEDFHARYSAMARRYRYIVYNHEIRPAILRKAIGWHYRPLDEKRMQAGAQYLIGEHDFSSFQGAGCQSRTPVRKIFQIEIYRIRRMVVIEVQANAFLLHMVRNIAGVLIAIGSGEKHPDWAQTVLKAKDRRQGGVTVPPNGLYLVEVNYPPNFKLPRMPLGPFFLP
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: FEN1_MICCC
Sequence: MGIKGLTKLLSDYAPGCMREQKFEGYLDRKVAIDASMHIYQFMMVVGRSGEQQLTNEAGEVTSHLQGMFTRTLRMLKAGIKPVYVFDGKPPTMKGGELAKRKDKREAAESALEKAKEAGDQEEIEKLSKRTVRVSKVHSEEVMKLARFLGLPVFEAPCEAEATCAALCKAGLVYAAASEDMDTLCFSTPKLARNLMAPSSQEKPILEFDFDKLLAGLELTWDQFIDVCILCGCDYCDSIKGIGPVNALKYIKQYGNIEGLLEHLDKEKYPVPDDWPYKEARVLFKNPEVVQTDGLTLKWTAPDEEAVVAFLCGEKSFNEDRIRKQLADLKKARSQGGQNRLETFFGAATVKSSTVGKRKEPEKGKGKFGAAGGKKSKGVTKRKF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: WAP1_PHIOL
Sequence: MTLRRGSCPLLLFSLVGLLTTCAQEPDAAGQNTTAVAEKAGTCPQAELEMPDRNCTEACQSDAGCEENKKCCRTGCGTSCQIPDEKPGSCPNVDTPIPPLGLCKTTCSKDSDCSETKKCCKNGCGFMTCTTARP
What is the function of this protein?
Damages membranes of susceptible bacteria.  Has no hemolytic activity.  Not toxic to mice.  Does not inhibit the proteinases elastase and cathepsin G.
What are the official names of this protein?
Waprin-Phi1.
What is the protein family that this protein belongs to?
Belongs to the snake waprin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS2_THEYD
Sequence: MSVVTMKELLEAGAHFGHQVKRWNPKMKKYIFAERNGIHIIDLQKTVKGIEEAYEFLKTVSAEGGSILFVGTKKQAQDAIQEEAKRAGVFYVNHRWLGGMLTNFATVRKSVEKWQRIEQMKEDGTLYLHTKKEIAKYEKERQKLELNLIGIKDMMEIPKAIFIVDIKKEKIAVEEAIKLGIPIAAIVDTNCDPDLVDYVIPGNDDAIRAIKLITSKMADAILEGKEIFMKKLEEEAEKAAIKEKILQEEEYQKSMDEYIEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: AIP2_ARATH
Sequence: MDASSSPSPSEESLKLELDDLQKQLNKKLRFEASVCSIHNLLRDHYSSSSPSLRKQFYIVVSRVATVLKTRYTATGFWVAGLSLFEEAERLVSDASEKKHLKSCVAQAKEQLSEVDNQPTESSQGYLFEGHLTVDREPPQPQWLVQQNLMSAFASIVGGESSNGPTENTIGETANLMQELINGLDMIIPDILDDGGPPRAPPASKEVVEKLPVIIFTEELLKKFGAEAECCICKENLVIGDKMQELPCKHTFHPPCLKPWLDEHNSCPICRHELPTDDQKYENWKEREKEAEEERKGAENAVRGGEYMYV
What is the function of this protein?
E3 ubiquitin-protein ligase that acts as a negative regulator of abscisic acid (ABA) signaling.  Mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ABI3.
What are the official names of this protein?
E3 ubiquitin-protein ligase AIP2, ABI3-interacting protein 2, RING-type E3 ubiquitin transferase AIP2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ECFA1_SPIKU
Sequence: MAKKTKKINVKLEKLNYISLKLTDVEFRYRENHPNAVDGVSFEINHGEYVTIIGHNGSGKSTISKIIIGVLRPQKGKIEVFGNEVHSSTITGIRKFLGIVFQNPDNQFIGSTVRDDIAFGLENRQIPQKKMQAIIEKAAAKVGMNNFLDHEPLMLSGGQKQRVAIASALALSPDIIIFDEATSMLDPKGRKEIKQIMVDLKESREKTIISITHDMDEILNSDKAIVMNKGQMVKCGKPHEVLYDEEFLKSIHLDVPFVSKVVDSLRLNGLKVKNTLNLRELVDEICQK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.