PharMolix/UniProtQA huggingface dataset:
Protein: G3P_CRIGR
Sequence: MVKVGVNGFGRIGRLVTRAAFTSGKVEVVAINDPFIDLNYMVYMFQYDSTHGKFKGTVKAENGKLVINGKAITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNQDKYDNSLKIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYEDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSDSHSSTFDAGAGIALNDNFVKLISWYDNEFGYSNRVVDLMAYMASKE
What is the function of this protein?
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively.  Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity).  Modulates the organization and assembly of the cytoskeleton.  Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity).  Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes.  Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.  Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity).  Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis.  Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, Peptidyl-cysteine S-nitrosylase GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Nucleus. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks.
Protein: MSRA_SALHS
Sequence: MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPNPTYREVCSGQTGHAEAVRIVYDPAVIRYEQLLQTFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQNAAAHASRERFQSAMAAAGDHRPITTEIAHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: TRMB_BRUME
Sequence: MIDENHPMRAAGNFFGRRHGKPLRPHQSNLFEDLLPRLKLDLATPAPQDLRSLFEAPVETVRMEIGFGGGEHLHHESGRYPQSGFIGVEPFINGMAKMLAALDQAPRPNLRLYDEDATAVLDWLPDASLAGIDLFYPDPWHKRRHWKRRFVSDANLDRFARVLKPGAKFRFASDIEHYVNWTLQHCRRHAAFDWQAESPADWNDAYEGWPGTRYEAKAFREGRRAAYLTFIRR
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: CSKMT_HUMAN
Sequence: MAALRRMLHLPSLMMGTCRPFAGSLADSCLADRCLWDRLHAQPRLGTVPTFDWFFGYDEVQGLLLPLLQEAQAASPLRVLDVGCGTSSLCTGLYTKSPHPVDVLGVDFSPVAVAHMNSLLEGGPGQTPLCPGHPASSLHFMHADAQNLGAVASSGSFQLLLDKGTWDAVARGGLPRAYQLLSECLRVLNPQGTLIQFSDEDPDVRLPCLEQGSYGWTVTVQELGPFRGITYFAYLIQGSH
What is the function of this protein?
Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308).  Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event (PubMed:28887308).
What are the official names of this protein?
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial, CS-KMT, Methyltransferase-like protein 12, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: RLMF_GRAFK
Sequence: MHPDNIHKDSYDFEALTESNPQLSEFVFQNKYGTQTINFANPEAVLQLNKALLKFHYQVENWSIPKQYLCPPIPGRADYIHYLNDLLSEENIQGEIRGIDIGVGANAIYPILASRIYDWKMLGTDIEEKSVAIAQANIETNPTIAKNIEIRHQEDRGSIFKGMIKKGEYYHFSICNPPFHASQEEANKATSRKFKNLGLEKGSALNFGGQANELWCNGGEALFIKRMIKESVLFKSQVGYFTSLVSKKENLPKIYKHLNKLKADFKTIEMGQGNKKSRIIAWKFD
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLR3_SCHPO
Sequence: MLASNSDGASTSVKPSDDAVNTVTPWSILLTNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGRLHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFEDWKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSLLVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISKNIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLVFVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).
What are the official names of this protein?
Histone deacetylase clr3, Cryptic loci regulator 3.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, telomere. Note=Associates with major heterochromatin, centromeres, sub-telomeres, rDNA and the mat locus.
Protein: SYS_STRP2
Sequence: MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVKVETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTTTLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTGARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTFELSDTNFVLIPTAEVPLTNYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSATKTYDLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEALRPYMGGAEVIKP
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYQ_PSEPK
Sequence: MSKPTADNAPNAAAKGAPAVPANFLRPIIQADLDSGKHSSIVTRFPPEPNGYLHIGHAKSICVNFGLAKEFGGVCHLRFDDTNPAKEDQEYIDAIQSDVKWLGFEWGGDVRYASDYFDQLHDWAVELIKRGKAYVCDLTPEQAKEYRGNLKEPGKNSPFRERSVEENLDLFARMKAGEFKDGERVLRAKIDMASPNMNLRDPILYRIRHAHHHQTGDKWCIYPNYDFTHGQSDAIEGITHSICTLEFEGHRPLYDWFLDNLPVPAHPRQYEFSRLNLNYTITSKRKLKQLVDEKHVDAWDDPRMSTLSGFRRRGYTPASIRNFCEMIGTNRSDGVVDMSMLEFSIRDDLDRTAPRAMCVLRPLKVVITNYPEGQVEQLELPRHPKEDMGVRVLPFSRELYIDRDDFMEEPPKGYKRLEPAGEVRLRGSYVIRADEAIKDADGNIVELRCSYDPDTLGKNPEGRKVKGVIHWVPAEGSVECEVRLYDRLFRSPNPEKTEEGGSFLDNINPASLQVLSGCRAEPSLAQAQPEDRFQFEREGYFCADLKDSQPGRPVFNRTVTLRDSWGS
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_STAAB
Sequence: MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATDEWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_TREDE
Sequence: MSRVCEICGKGSLSGNSVSKSKIHTKRVWKPNLVNVKTEIGGRTLTIKMCSRCLKSDYVTKKV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: LIMK2_RAT
Sequence: MAALAGEEAWRCRGCGNYVPLSQRLYRTANEAWHSSCFRCSECQESLTNWYYEKDGKLYCHKDYWAKFGEFCHGCSLLMTGPAMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQDQLPYSVTLISMPATTECRRGFSVSVESASSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAINQTSQTLQLLIEHDPVPQRLDQLRLDTRLSPHMQSSGHTLMLSTLDAKENQEGTLRRRSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRNVDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKAATKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSFEALSLFLGELAIPLPAELEELDHTVSMEYGLTRDSPP
What is the function of this protein?
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics.  Acts downstream of several Rho family GTPase signal transduction pathways.  Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP.  Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.  Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity).
What are the official names of this protein?
LIM domain kinase 2, LIMK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
[Isoform LIMK2A]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform LIMK2B]: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: RL19_BURPS
Sequence: MNLIAKLEQEEIERALAGKTIPEFAPGDTVIVNVNVVEGNRKRVQAYEGVVIAKRNRGLNSSFIVRKISSGEGVERTFQTYSPLLASIVVKRRGDVRRAKLYYLRERSGKSARIKEKLVSKDRAAAAQQ
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: KMO_FLAPJ
Sequence: MQKSQKIAIVGSGLVGSLLAIYLKKEGHTVHVYDRSPDIRTIQFSGRSINLAMSNRGWNALDGAGVGDKVRHIAIAMEKRAIHIGNQLNFQHYGLQGECIYSISRGVLNRKMIDLAEEAGAEFFFEQKIWDVNLTDATLQMGETERGEWTNVSYDMVFGADGAFSRIRHRMQRQSMFNYSQDFLNTGYKELHIPANPDGSYKLDKHSLHIWPRGKYMLIALPNLDGSFTCTLFMPFEGENSFASLDNRQKVEAFFAENLPDTVDVIPDLAEDFFKNPTSTLVTMKCFPWTYSDKVALIGDAAHAIVPFYGQGMNAGFEDITILYQMMQEYGNDWKTIFSEYEKSRKPDADAIAELSYRNFMEMSTKTANEKFLLQKKIERWFASKYPEKWIPLYDRVTFSTRPYSEALAIGDFQETIMQEILKIENIETNWETEEIEHKIIQLLNSK
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Protein: TWST1_EULFU
Sequence: MMQDVSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGVGGGDEPGSPAQGKRGKKSAGCGGGAGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH
What is the function of this protein?
Acts as a transcriptional regulator.  Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction.  This interaction probably involves the basic domains of both proteins.  Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B.  Regulates cranial suture patterning and fusion.  Activates transcription as a heterodimer with E proteins.  Regulates gene expression differentially, depending on dimer composition.  Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression.  Heterodimerization is also required for osteoblast differentiation.  Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer (By similarity).
What are the official names of this protein?
Twist-related protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPA_CAMJ8
Sequence: MDKNIIIGAMTALITPFKNGKVDEQSYARLIKRQIENGIDAVVPVGTTGESATLTHEEHRTCIEIAVETCKGTKVKVLAGAGSNATHEAVGLAKFAKEHGADGILSVAPYYNKPTQQGLYEHYKAIAQSVDIPVLLYNVPGRTGCEISTDTIIKLFRDCENIYGVKEASGNIDKCVDLLAHEPRMMLISGEDAINYPILSNGGKGVISVTSNLLPDMISALTHFALDENYKEAKKINDELYNINKILFCESNPIPIKTAMYIAGLIESLEFRLPLCPPSKENFAKIEEVMKKYKIKGF
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUKB_VIBCM
Sequence: MIERGKYQSLTMINWNGFFARTFDIDNLVTTLSGGNGAGKSTTMAAFITALIPDQSLLHFRNTTEAGSSQASRDKGLYGKLQAGACYAALDVVNSRNQRLLFAVKLQQVAGRDKKVDIKPFLIQGLPSHVKPTDVLVETVSDKHARVRQINEVKDAVGQIEGAHFKSFPSIVDYHAQMFEFGVIPKKLRNSSDRSKFYRLIEASLYGGISSAITRSLRDYLLPQNGGVKKAFQDMESALRENRMTLEAIKTTQADRDLFKHLITESTNYVAADYMRHANDRRNKVGQTLVLRGELFSSRETLIEQNSLLNRVHEELELLVEQESALEQDYQGASDHLQLVQNALRQQEKIERYQEDLEELNFRLEEQMMVVEEANERVMQAEERAIISEEEVDSLKSQLADYQQALDVQQTRALQYQQAVQALDKARRLLDKSELTAESAQALATQLKAEQETRTSELLALKHKLDMSSAAAQQFNHAFELVKRVLGEVARSEAAKQAQQVIRQAREAQNVVQNEAQWQAQQRDLERQLEQQRSVRELATQYHKQHRVVLDDAATVELERERHSALLEELETEQENCREQRGQLRHQEQELQTQIARFESIAPAWIKANDALETLREQSGAELADSQSVMAHMQQVLELEKAQSMAKDKLAERRTKLDSEIERLASPGGSNDPRLKGLADTLGGVLLSEIYDDITIDDAPYFSAMYGPARHAIVVSDLSGIKEKLVELDDCPEDLYLIEGDVDAFDDSSFNAEELEGAVCVQLNQRQMRYSRFPAIPLFGRAAREQRLELLREERDDVVEQHAKASFDSQKLQRLYASFNQFVAMHLQVAFDADPEQALATARDKRNQLLRSISEFEAQEQQLRSQLQASKQALAALDKLAPQMGLLDEETLEARYHELEEKLQQLSEAKAFIAAHGRTISELEKVAAVLDADPEQFDALEQQYQQADQALQQLKAQIFALSDLLERRHHFAYSDSVDLLNQSSELSEQLKAKLVQAESERTRSREELKQAQAQLSQYNQLLASLKSSHQAKLETVQEFKQELQEFGVHADEGAIERAQRRRDELQERLHTSRSRKSEYERTITSTELEMKALVKRMKKVEKDYQDLRTFVVNAKAGWCSVLRLARQNDVERRLHKRELAYLSADELRSMSDKSLGALRLAVANNEDLRDALRQSEDNSRPERKVLFYIAVYQHLRERIRQDIIRTDDPVEAIEEMEVELARLTEELTQREQRLAISSDSVASIIRKTIQREQNRIRMLNQGLSNISFGQVNGVRLNVKVRESHEILLAGLSEQQAQHKDLFESARYTFSEAMAKLFQRVNPHIDMGQRSPQVLGEELLDYRNYLELSVEVNRGSDGWLQAESGALSTGEAIGTGQSILLMVVQSWEEESRRLRSKDIVPCRLLFLDEAARLDAKSIATLFELCERLDMQLLIAAPENISPEKGTTYKLVRKVFKDHEHVHVVGLRGFAQTEKPKTAEQKFAEELAGELTE
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: PSAI_ADICA
Sequence: MTASYLPSILVPLVGILLPAVTMASLFLYIERDEIL
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RNPH_GLOC7
Sequence: MPWTRPDSRQPDQLRPILFETNYSRFRVGSVLAHCGETRVLCTATIQPNVPKFLLNSGKGWLTAEYRMLPGATPERQSRELMQLSGRTQEIQRLIGRSLRACLDFERLGERTIIIDTDVLQADAGTRTTAITGGYIALGLAIKKLLEVGELQESPLKLPVAAVSVGLIEGEPFLDLNYAEDTAAEVDFNVVMTGNLDLIEVQGTAESGSFSRLQLNQLLDLAQTGIQELLVAQQNAINSTYQ
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: METAS_ECO57
Sequence: MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEYFRDVEAGLDPEVPYNYFPHNDPQNKPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPT1B_BOVIN
Sequence: MAEAHQAVAFQFTVTPEGVDFQLSREVLKHIYLSVIRSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATAGSSYYNVDISMGLVYYIQRWLPEGRPYRTPYTRTLFSMAIFSTGVWMMGIFFFRQTLKLLLSYHGWMFELHGQTSHLTRVWAVCVRLLSGRRPMLYSFQTSLPKLPVPSVPATVHRYLESVEHLLDDEQYYRMETLAKEFEEKTAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRNPIVVNSNYYVMDLVLVKNTDVQAARLGNAVHAMITYRRKLDREEIKPVMALGLVPMCSYQMERMFNTTRIPGKDTDVLQHLPDSRHVAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEERLAALTAGGRVEWAQARQAFFSSGKNKAALDAIERAAFFVALDEESHHYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNTEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPVLPPPQRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTRESTAFVQAMVQGRHLNEDLQRLFRKAAEKHQNMYRLAMTGAGIDRHLFCLYVVSKYLGVESPFLAEVLSEPWRLSTSQIAQFQIRMFDPNKYPKHLGAGGGFGPVADDGYGVSYMIAGENTIFFHVSSKFSSSETNAQRFGNQIRQALLDIANLFQVPKADG
What are the official names of this protein?
Carnitine O-palmitoyltransferase 1, muscle isoform, CPT1-M, Carnitine O-palmitoyltransferase I, muscle isoform, CPT I, CPTI-M, Carnitine palmitoyltransferase 1B.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: TOX3_RAT
Sequence: MDVRFYPAAAGDPAGLDFAQCLGYYGYSKLGNNNYMNMAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPTLGMPDVLLPFQTLSDPLPSQGNEFTPQFPPQSLDLPSITISRNLVEQDGVLHSNGLHMDQSHTQVSQYRQDPSLVMRSIVHMTDAARSGIMPPAQLTTINQSQLSAQLGLNLGGASVPHTSPSPPASKSATPSPSSSINEEDADETNRAVGEKRTAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTSLSQHGTVPASPQTLPQSLPRSIAPKPLTMRLPMSQIVTSVTIAANMPSNIGAPLISSMGTTMVGSVSSTQVSPSVQTQQHQLQLQQQQQQQQQQMQQMQHQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQQHLQQQISQQQLQQQLQQHLQLQQQLQHMQHQSQPSPRQHSPVTSQITSPIPAIGSPQPASQQHQPQIQSQTQTQVLPQVSIF
What is the function of this protein?
Transcriptional coactivator of the p300/CBP-mediated transcription complex.  Activates transactivation through cAMP response element (CRE) sites.  Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts.  Stimulates transcription from the estrogen-responsive or BCL-2 promoters.  Required for depolarization-induced transcription activation of the C-FOS promoter in neurons.  Associates with chromatin to the estrogen-responsive C3 promoter region.
What are the official names of this protein?
TOX high mobility group box family member 3, Trinucleotide repeat-containing gene 9 protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: VPX_SIVSP
Sequence: MSDPRERIPPGNSGEETIGEAFDWLDRTVEEINRAAVNHLPRELIFQVWRRSWEYWHDEMGMSVSYTKYRYLCLIQKAMFMHCKKGCRCLGGEHGAGGWRPGPPPPPPPGLA
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells.  Targets specific host proteins for degradation by the 26S proteasome.  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1.  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1.  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.