PharMolix/UniProtQA huggingface dataset:
Protein: LOLD_NEIMB
Sequence: MSELILKCEGVGKRYRDGGLDVRVLHGLDLEIHAGESTGIIGSSGSGKSTLLHILGGLDMPSEGRVLLMGEDLRTLNQRRLGDLRNRHLGFVYQFHHLLPEFSALENVMMPLLIGKKSREEAAEAAMAMLEKVGLKHRSTHRAGELSGGERQRAAIARALVTQPKCLLADEPTGNLDRANARNVLDMMLELKTELGTGLVVVTHDDELAGRFERVMVMKDGSLHPKQGANA
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PYGM_RAT
Sequence: MSRPLSDQDKRKQISVRGLAGVENVSDLKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVDRWIRTQQHYYAKDPKRIYYLSLELYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPPYFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDKFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELIRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEEYISDLDQLRKLLSYLDDQAFIRDVAKVKQENKLKFSAYLETEYKVHINPNSLFDVQVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPAVGDRFRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEDNFFIFGMRVEDVERLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMVMHHDRFKVFADYEEYIKCQDKVSELYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGLEPSRQRLPAPDEKI
What is the function of this protein?
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
What are the official names of this protein?
Glycogen phosphorylase, muscle form, Myophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the glycogen phosphorylase family.
Protein: RK18_GRATL
Sequence: MKKKIRGTKNRPRLCVFRSNKHIYAQIIDDTNNKIIATSSTLVILSEQNKKISNDCHAAHKIGQNIAQKSKALGIKKVIFDRQNKIYHGRIKALAEAVREEGIEF
What is the function of this protein?
Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSD_RICTY
Sequence: MKQYNDLFKIIHREGYIFIASFALVSFLLASFNEKLGCIGFIATIWCIYFFRNPDRFVPISDDLVISPADGIIQEIKEASPPPELGLGDLEMIRVSIFLNIFNIHVNRIPANGKILALHYNPGKFFNASLDKASLYNERQSVLMETDQGQKIVFVQIAGLIARRIVCDLEEDNEVKMGERYGIIRFGSRVDVYLPLKTALLVSKGQTAIGGETIIADFGRKKTEEFKFERK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HOLA_BUCBP
Sequence: MKIIHSENLFSYSFKTLSSYYVIVGNVKHLIQQSTNIILNLAKKNGFSKMSKIIFCDPIYINNIILSAKSQNLFFKKKIISISFKKYISIKEVQNYILKLKKYLHTNLLLIIYIYSTNTNILNKINTKIFPPNGTMITCTFFNQNNISIWTKYKIKNIKMNITKNAENLLIQYHQGNVLHLNNTLNILSLVWKNKLINTLSITNFIEDCSIFKPLQWINALLNNNLQFSIKILNQFENQNFNPIILIRYLQHDLLTILLIKRDDVKNYYNILKNRNTNKNRHSLIINYARRKHYKTIYKSIKLLTLIELQIKKNNTKLIWLPFYTLSIIICL
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA (By similarity).
What are the official names of this protein?
DNA polymerase III subunit delta.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase HolA subunit family.
Protein: TXL3A_SCOMO
Sequence: MKIIALLLMVFLDFIIVNXAEQNEKKRRDNLGIPGAGDTEDANQAYKIAQDLQYKNSDSSPGKRSIMLSKLKNNAKRQFSEN
What are the official names of this protein?
U-scoloptoxin(21)-Sm3a, U-SLPTX(21)-Sm3a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-21 family.
What are the subcellular locations of this protein?
Secreted.
Protein: IMDH1_HUMAN
Sequence: MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.  Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.  It may also have a role in the development of malignancy and the growth progression of some tumors.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase 1, IMP dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y1028_FRATN
Sequence: MAGHSKWANIKHKKAKEDAKRGKIFTKLIREITVAARLGGGDKDANPRLRAAIATALANNMSKDTIERAVVKGAGGDESANVEEVRYEGYGPGGVAIIVDCMTDNRNRTVGEVRHAFTKSGGNLGTDGSVAYMFTKRGIISFAPGVDEDALMEVALEAGAEDIITHEDGSIDVYTDPYDFSDIQEVLIEKGFNSENAEVTFDAETKAELDAETAEKVMALIDKLEDLDDVQSVYSNANFTQELIEQIG
What are the official names of this protein?
Probable transcriptional regulatory protein FTN_1028.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_EXISA
Sequence: MKRVLVKGIQGYQRFISPLKPPTCRFYPSCSHYGIEAIEKHGAVKGSYLTARRLIRCQPFHPGGLDYVPDTFDWKAPLQREKPESQRDD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL30_RHOPA
Sequence: MAKAANMIKVEQIGSPIRRHHSQRETLIGLKLNKIGRVAELQDTPEVRGMIGKVQHLVRVVDEK
What are the official names of this protein?
50S ribosomal protein L30, RRP-L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: NHAP2_AERS4
Sequence: MDAVTINSFFLVAALLVGASVLLSALSSRLGIPILVIFLAVGMLAGEDGPGGIHFADYSVAYLVGNLALAIILLDGGMRTRVSSFRVALWPALSLATVGVAITTGLTGLAAAWLFDLNLMQGMLIGAIVGSTDAAAVFSLLGGRSLNERVSATLEIESGSNDPMAVFLTVTLIEILATNQQGLDWFFLLLQLGKQFGLGAGIGLGGGWLLWKLINSARLAPGLYPLLTVSGGLLIFALTTAIGGSGILAIYLTGLLLGNLSLRSRSTTLSVLDGLTWLSQIGMFLVLGLLASPHKLLPIALPALALAAWMILFARPVSVWIGLLPFKNFAPRERWFISWVGLRGAVPIILAVFPMMAGLPNAQLYFNVAFFVVLVSLILQGSSLPLASKLARVEVPAPPSPINRSGLEIDLDSQWETFVYRLSAEKWCIGSPLRDLRMPKGTRICALFRDQELLHPSGSTCLQSNDILCVIGHERDLPALGQLFSQAPEQDLGPRFFGDFLLEAAANMVDLAPLYGLDVSEVADQTLGDFLADQLGDNLVVGDQVEWQGLIWTVAEMEEGKPRKIGVRFQEEDPV
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TTCA_BURO1
Sequence: MNDTAADAATLDDAAAPAGRPALTRREQKEAYENNKLFKRIVRQVGQAIGDYNMIEQGDKVMVCLSGGKDSYAMLDVLLRLRERAPIDFDIVAVNLDQKQPGFPEHVLPEYLKQVGVPFHIENQDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVAGELGATKIALGHHRDDIVQTLLLNMFYGGKLKGMPPKLQSDDGKNIVIRPLAYVKETDLEKYAELREFPIIPCNLCGSQPNLKRAEMKALIREWDKRFPGRVDNMFNALAKVVPSHLMDTTLYPFQSLRATGEADPQGDIAFDEEPCASGDDAAAPGAAQPISIVQFDDL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
Protein: SSTT_SHIFL
Sequence: MTTQRSPGLFRRLAHGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPILVLMLVMASIANHQHGQKTNIRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGDISPPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLGFALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPFGIFGLVSSTLATTGFSTLWGYAQLLVVLVGCMLLVALVVNPLLVWWKIRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVNTLGIPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGISNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQAEDDRLANSALRN
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FENR1_BACMK
Sequence: MNQEELFDVTVIGGGPAGLYSAFYSGLREMKTKIIEFQPQLGGKIHVYPEKMIWDIGGLLPVTGEKLIEQLVQQGLTFQPEVVLNTKIESIIRNQDGIFTLKTSSGEEHFSKTVIVATGSGILNPQKLSIEGAERFEVSNLNYTVKSLKRFKDKTVIISGGGNSAIDWANELEPIAKKVYLTYRKEELSGHEAQVKQLMNSSAECFFNTSITKLIAGDNHEAIEYVELTNHETGEVSHLSIDEVIINHGYERDITLLENSELDVAIVDNYYIAGNANSESSVDGLYAAGDILKHDGKLHLIAGAFQDAGNAVNKAKQFIQPDASEYGMVSSHNEVFKKRNRELIKQMMK
What are the official names of this protein?
Ferredoxin--NADP reductase 1, FNR 1, Fd-NADP(+) reductase 1.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: EASA_ASPFU
Sequence: MREEPSSAQLFKPLKVGRCHLQHRMIMAPTTRFRADGQGVPLPFVQEYYGQRASVPGTLLITEATDITPKAMGYKHVPGIWSEPQREAWREIVSRVHSKKCFIFCQLWATGRAADPDVLADMKDLISSSAVPVEEKGPLPRALTEDEIQQCIADFAQAARNAINAGFDGVEIHGANGYLIDQFTQKSCNHRQDRWGGSIENRARFAVEVTRAVIEAVGADRVGVKLSPYSQYLGMGTMDELVPQFEYLIAQMRRLDVAYLHLANSRWLDEEKPHPDPNHEVFVRVWGQSSPILLAGGYDAASAEKVTEQMAAATYTNVAIAFGRYFISTPDLPFRVMAGIQLQKYDRASFYSTLSREGYLDYPFSAEYMALHNFPV
What is the function of this protein?
Aldehyde reductase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid (PubMed:15933009, PubMed:22453123).  DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:15870460).  The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity).  The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethylallyl-L-abrine to chanoclavine-I which is further oxidized by EasD in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:20039019, PubMed:20526482, PubMed:21409592).  EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:20526482).  EasG then catalyzes the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:20526482).  Hydrolysis of festuclavine by easM then leads to the formation of fumigaclavine B which is in turn acetylated by easN to fumigaclavine A (PubMed:26972831).  Finally, easL catalyzes the conversion of fumigaclavine A into fumigaclavine C by attaching a dimethylallyl moiety to C-2 of the indole nucleus (PubMed:19672909).
What are the official names of this protein?
Chanoclavine-I aldehyde reductase easA, Ergot alkaloid synthesis protein A, Old yellow enzyme 3 homolog.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: KAX6X_OPICY
Sequence: IRCTGSKECYSPSY
What is the function of this protein?
Blocks voltage-gated potassium channels.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 6 OcyKTx4.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 06 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SGMR2_MOUSE
Sequence: MGALAARRCVEWLLGLYFVSHIPITLFIDLQAVLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLLCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAAHTITTLIPILYTLLFEDFSKAVAFKGQRPESFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKYEEKRKKK
What is the function of this protein?
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells.  Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation.  May play a role as a regulator of cellular cholesterol homeostasis.  May function as sterol isomerase.  May alter the activity of some cytochrome P450 proteins.
What are the official names of this protein?
Sigma intracellular receptor 2, Sigma-2 receptor, Sigma2 receptor, Transmembrane protein 97.
What is the protein family that this protein belongs to?
Belongs to the TMEM97/sigma-2 receptor family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Rough endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated.
Protein: RL24_GRAFK
Sequence: MTKLKIKSGDTVRVIAGDHKGQEGKVQKVLIEKNKAIVEGVNMISKHEKPSASNPQGGIKEKEAPIHISNLSLIDKNGDTTRVGYKEEDGKKVRFSKKSNEVI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: ETHA_MYCTU
Sequence: MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGIDRHIRFHHKVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDELPKQGSRTPWRLNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV
What is the function of this protein?
Is responsible for the activation of several thiocarbamide-containing pro-drugs into cytotoxic species.  Thus, catalyzes the oxidation of the antitubercular pro-drug ethionamide (ETH) to the corresponding sulfoxide, which is further oxidized by EthA to 2-ethyl-4-amidopyridine, presumably via the unstable doubly oxidized sulfinic acid intermediate; the final metabolite 2-ethyl-4-amidopyridine has no antitubercular activity, so the cytotoxic species is a metabolite intermediate formed by EthA.  Also oxidizes thiacetazone (TAC), thiobenzamide, and isothionicotinamide and therefore is probably responsible, as suggested by the observation of crossover resistance, for the oxidative activation of these other thioamide antitubercular drugs.
What are the official names of this protein?
FAD-containing monooxygenase EthA, Baeyer-Villiger monooxygenase EtaA, BVMO, Prodrug activator EtaA.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
What are the subcellular locations of this protein?
Cell membrane. Note=Is most likely membrane-associated.
Protein: COAA_NITHX
Sequence: MDLRAEQQQYNPYRIFSRSEWAKLRDDMPMTLAADEIAALRSMHDRLDLTEVEEIYLPLSRLLSIYVASMQRLFVAQRRFLGIQDRKVPYIIGVAGSVAVGKSTTARVLQALLARWSPGPKVDLITTDGFLFPNAVLERHGLMQKKGFPESYKLPMLLAFLSDIKAGRAPVRAPVYSHLTYDIVPKSWIEVSQPDILIVEGVNVLQTGRLPRDGRAVPVVSDFFDFSVYLDAEEPVLRDWYVKRFLALRDTAFHDPRSYFHRYALLSDDEATATAIAIWERTNRANLEDNILPTRPRATLILKKGADHVVEQVALRRL
What are the official names of this protein?
Pantothenate kinase, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SELA_YERPA
Sequence: MSAEPHPLYRQLPAIDRLLNEPEMAPLLAEYGPVLLADTLRQLQAEAREYIGQFHTLADWCADWPAALRQRLNQRQPALKPVFNLTGTVLHTNLGRAPLAESAIAAVTDAMRSAVTLEYSLEGAGRGHRDRAVADLLCALTGAEDACIVNNNAAAVFLLLTVMAAGKQVVVSRGELVEIGGAFRIPDVMRQAGCELVEVGTTNRTHLKDYRQAINENTGLLMKVHTSNYSIEGFTAAVSEQQLAALGQECSIPTATDLGSGSLVDMTRYGLPAEPMPQQLIAAGVDLVTFSGDKLLGGPQAGIILGKKQWIERLQQHPLKRALRADKMTLAALDATLRLYQQPDRLVEQLPSLRLLTRPASEIAACAQRLLAPLIACYGTDFTLDIESCWSQIGSGSLPVDRLPSWALTFTPKDGRGSTLEALTARWRTLTKPVIGRVADGRLWLDLRCLEDEAALLRELAS
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISA1_YEAST
Sequence: MINTGRSRNSVLLAHRFLSTGGFWRGGTNGTMSRTINNVNPFKLKFIPKTVPAAADSVSPDSQRPGKKPFKFIVSNQSKSSKASKSPKWSSYAFPSRETIKSHEEAIKKQNKAIDEQIAAAVSKNDCSCTEPPKKRKRKLRPRKALITLSPKAIKHLRALLAQPEPKLIRVSARNRGCSGLTYDLQYITEPGKFDEVVEQDGVKIVIDSKALFSIIGSEMDWIDDKLASKFVFKNPNSKGTCGCGESFMV
What is the function of this protein?
Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins.  Probably involved in the binding of an intermediate of Fe/S cluster assembly.
What are the official names of this protein?
Iron-sulfur assembly protein 1.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NTPPB_NEIMB
Sequence: MGLELPLILGTSSVFRREQMERLGIAFQAASPDFDETPMLGESAPQTALRLAEGKARSLTGRFPEALIVGADQVAWCDGRQWGKPMNLANAQKMLMHLSGREIEFYSAIVLLNTVTGRMRRHIDKTVVVMRQLDELHILRYLEREPDAVYCSCALKSEDLGALLIERIESTDPNALIGLPVFRLVDFLKNEGVEVL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_SHESH
Sequence: MLKLYNSLTRQKEEFKPLQPGKVGMYVCGITIYDLCHIGHGRTFVSFDMIVRYLRYSGYDVNFLRNITDVDDKIIKRANENKESCESLTERLIGEMHRDFDALNMKRPDFEPRATLHIPEIIDMVEKLIEKEHAYVSGNGDVLFSVSSFPEYGRLSGQNLDQLQAGARVEVEDTKRDPMDFVLWKMSKPGEPTWESPWGPGRPGWHIECSAMNSKHLGQHFDIHGGGSDLQFPHHENEIAQSCCAHNTPYVNYWMHTGMVMVDKEKMSKSLNNFFTIRDVLEHYDAATVRYFLLSGHYRSQLNYSEDNLKQAKSALERLYTSLKGLDLSVEAASADEYVAKFKVAMDDDFNTPEAYSVLFEMVREINRLKEADNAKASSLGVKLKELADVLGILDQDVDTFFKGEGSTDEVAEIEALIAERNRARAEKDWPAADVARDGLNALGVILEDGPEGTTWRKK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROD_STRSV
Sequence: MKLVVSVMPKSLEEAQEIDVSRYEEADIIEWRADFLAKDDILNVAPAIFEKFAGRELIFTLRTRQEGGEIELSDDEYVALIKEVAGFYQPDYIDFEYFSHKGKFEEMLEFPNLVLSYHNFEETPENMMEILSELTSLTPKVVKVSVMAHNEQDVLDLMNYTRGFKTLNPEQDFVTISMGKVGRISRIAADLTGSSWSFASQDMASAPGQISLSNMKKIQEILNEN
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: RGD1_YEAST
Sequence: MEETAKKPASATVSAKSSHDGGTDDLAHLFSTPEIKKVLNSDVAINALLSRLKQSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHFFNIQGSTNSSLKKMIHEVLGFDGKMAQVKQSYITALQKMYSEISSLLLTMTKLRKSVKENSKRLEKDVSDAIHSAEKAQSRYNSLCQDWDKLRMTDPTKTKLTLRGSKTTKEQEEELLRKIDNADLEYKQKVDHSNSLRNTFITKERPRIVQELKDLILEIDTAMTIQLQKYTIWTENLVLNTGVTISPLDSTKSMKSFAGSVSNERDLYSFLNKYNQTGKHSLLINKNLIPVSYKKHPSMNHGQKNKSPPKFAVDPSRNSIPKRMISTHNESPFLSSSSNTAAVPNANLNSATPSLNTNKQLPPTMASSISSTSNAAGAMSPSSSIVTSDTTSSITKTLDPGNNSPQIPEELINSLDSDRPISHIQTNNNMPPGVQKNFKTFGVPLESLIEFEQDMVPAIVRQCIYVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDPANISMILPSKPHSDSDIYLVGSLLKTFFASLPDSVLPKALSSEIKVCLQIEDPTTRKNFMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWGPTIAPANPDDANDVNFQIMAMEVLLEVSDQAFEPE
What is the function of this protein?
GTPase activating protein of RHO3 and RHO4.  Acts in concert with MID2 in cell integrity, which is functionally linked to the PKC pathway.  Involved in various stress responses.  Required at low pH for activation of the PKC pathway.  Important during mating response.
What are the official names of this protein?
RHO GTPase-activating protein RGD1, RhoGAP, Related GAP domain protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Note=Bud and bud neck. During isotropic bud growth in the G1 and S phases, detected at the bud tip. During cytokinesis, undetectable at the bud tip and localized at the bud neck only.
Protein: NP03_EHV1B
Sequence: MESALTVLSGWGWPVEVVTGPVADHLTEMRPPAPTGTTCTTTSTPTPLCVPDLSVESIKGLAPDGENANYVGFDTMFMVSSIDELGRRQLTDTIRKDLRVTLAKFTIACTKTSSFSSASSTRRRKRHCPSSERVMRSNKSLQMFVLCRRAHAKQIRDQLQSVIQARKPRKYYTRSSDGRTHPVVPVYIYEFSAVDKVYLHRDNVIEADAQAK
What are the official names of this protein?
Nuclear phosphoprotein UL3 homolog, ORF60 protein.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae HHV-1 UL3 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: AROC_CORGL
Sequence: MLGMLRWTTAGESHGQALIATVEHMPAGVPVTKDEVSYQLARRRLGYGRGARMKFEQDALTFLTGIRHGLTLGSPISIMIGNTEWDKWTTIMSSDALDMEDPDNVAAMSSGRGAKLTRPRPGHADYAGMLKYGFDDARNVLERSSARETAARVAAATVARSFLRETLGVEVLSHVISIGASEPYTGAEPTFADIQAIDDSPVRAFGKDAEESMIAEIEAAKKAGDTLGGIVEVIVEGLPIGLGSHISGEDRLDAQIAAALMGIQAIKGVEIGDGFEEARRRGSEAHDEVFLDDNGVYRNTNRAGGLEGGMTNGETLRVRAGMKPISTVPRALKTIDMENGKAATGIHQRSDVCAVPAAGVVAEAMVTLVLARAVLQKFGGDSLSETKSNIDTYLKNIEERMKFEGLEDGA
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.