PharMolix/UniProtQA huggingface dataset:
Protein: CAV1_MUNRE
Sequence: MSGGKYVDSEGHLYTVPVREQGNIYKPNNKAMAEEMNEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLFEAIGKIFSNIRINMQKEI
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes.  Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation.  Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity).  Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).  Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.  Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity).  Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).  Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
What are the official names of this protein?
Caveolin-1.
What is the protein family that this protein belongs to?
Belongs to the caveolin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Protein: SODC_NICPL
Sequence: MVKAVAVLSSSEGVSGTIFFTQDGDAPTTVTGNVSGLKPGLHGFHVHALGDTTNGCMSTGPHYNPAGKEHGAPEDEVRHAGDLGNITVGEDGTASFTLTDKQIPLAGPQSIIGRAVVVHADPDDLGKGGHELSKTTGNAGGRVACGIIGLQG
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYL3_HUMAN
Sequence: MLVLNCSTKLLILEKMLKSCFPESLKVYGAVMNINRGNPFQKEVVLDSWPDFKAVITRRQREAETDNLDHYTNAYAVFYKDVRAYRQLLEECDVFNWDQVFQIQGLQSELYDVSKAVANSKQLNIKLTSFKAVHFSPVSSLPDTSFLKGPSPRLTYLSVANADLLNRTWSRGGNEQCLRYIANLISCFPSVCVRDEKGNPVSWSITDQFATMCHGYTLPEHRRKGYSRLVALTLARKLQSRGFPSQGNVLDDNTASISLLKSLHAEFLPCRFHRLILTPATFSGLPHL
What is the function of this protein?
Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.
What are the official names of this protein?
Glycine N-acyltransferase-like protein 3, Acyl-CoA:glycine-N-acyltransferase-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the glycine N-acyltransferase family.
Protein: AV238_PHYSP
Sequence: MRGVFFVAVAVAIFARSSAEAKLLSEAAPGLAADAVISGESRERFLRVADPEDDDLAAPADDGKTEERAPKFKSLNEIHKKLDEEDMVHVSKILGNMGAIHADNIAKARAALKAAHESGATTANQLVAGLAKPV
What is the function of this protein?
Effector that suppresses plant defense responses during the early stages of pathogen infection.  Suppresses cell death induced by effectors and PAMPs in plant hosts (PubMed:21653195).  Is able to induced cell death in tomato, tobacco, eggplant, and potato, but not in A. thaliana (PubMed:28134441).  Interacts with and destabilizes host 1-aminocyclopropane-1-carboxylate synthases.  By suppressing type2 ACS-catalyzed ethylene biosynthesis, Avh238 facilitates Phytophthora infection (PubMed:30394556).
What are the official names of this protein?
RxLR effector protein Avh238, Avirulence homolog protein 238.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus. Note=Avh238-triggered cell death requires nuclear localization whereas cytoplasmic localization of Avh238 is required for the suppression of INF1-induced cell death.
Protein: CLPS_PECAS
Sequence: MGNNRTWSQSESLTADQQKEKLQPPSMYNVVLNNDDYTPMEFVIDVLQKFFSYDIERATQLMLTVHYQGKAICGVFSAEVAETKVVQVNRYARENEQPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: ENPP4_MOUSE
Sequence: MFNMKILVIPLFWGLVTGYKGNSSDSSAPRLLLVSFDGFRADYLKSYDLPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDSVTKKHFSESNDKDPFWWNGAEPIWVTNQLQENRSSAAAMWPGTDVPIHNITASYFMNYSSSVSFKERLGNVTTWLSSSNPPVTFAALYWEEPDVSGHKYGPEDKENMRRVLKEVDDLIGDIVLKLKVLGLWDSLNVIITSDHGMAQCSKNRLIDLDSCIDRSNYSVIDLTPVAAILPKINVTEVYDKLKRCNPHMNVYLKEAIPNRFYYQHSSRIQPIILVAEEGWTITLNKSSFKLGDHGYDNSLPSMHPFLAAHGPAFRKGYRQSTINTVDIYPMMCHILGLKPHPNNGTLSHTKCLLVDQWCINLPEAIGIVVSALLVLTMLTGLMIFMRSRASTSRPFSRLQLQEDDDDPLID
What is the function of this protein?
Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP.  Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells.  Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity).
What are the official names of this protein?
Bis(5'-adenosyl)-triphosphatase enpp4, AP3A hydrolase, AP3Aase, Ectonucleotide pyrophosphatase/phosphodiesterase family member 4, E-NPP 4, NPP-4.
What is the protein family that this protein belongs to?
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PYRG_CERSK
Sequence: MARYVFITGGVVSSLGKGLASAALGALLQARGFSVRLRKLDPYLNVDPGTMSPFEHGEVFVTDDGAETDLDLGHYERFTGVSARKTDSVSSGRIYSNVLEKERRGDYLGKTIQVIPHVTNEIKDFLRVGEDEVDFMLCEIGGTVGDIEGLPFFEAIRQFAQDKPRGQCIFVHLTLLPYVSASGELKTKPTQHSVKELRSIGIAPDVLLLRSERAIPEKEREKIALFCNVRKEAVIAAYDLKTIYEAPLAYHREGLDQAVLDAFGISPAPKPNLDRWVDVMDRLENAEGEVRVAIVGKYTQLEDAYKSIAEALTHGGMANRTRVRAEWINAELFEREDPSPFLEGFHAILVPGGFGERGTEGKIRAAQYAREKGIPYLGICLGMQMAVIEAARNLAQVKDAGSEEFDHEVGKKRFTPVVYHLKEWIQGNHIVERKHDDDKGGTMRLGAYTAALTPGSRVSEIYHATEIEERHRHRYEVDVRYREALEGCGLTFSGMSPDGRLPEIVEIKDHPWFIGVQFHPELKSKPFAPHPLFADFVRAAVEVSRLV
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PYRH_YERPA
Sequence: MATNAKPVYQRILLKLSGEALQGAEGFGIDASVLDRMAQEVKELVELGIQVGVVIGGGNLFRGAGLAQAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDNYSWAEAISLLRHNRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVKNPDATLYEQLTYQDVLEQELKVMDLAAFTLARDHNLPIRVFNMNKPGALRRVVMGENEGTLIAK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNAA_VIBPA
Sequence: MKRIPEPFRIKMVEPIKMTTLADREIALKEAGYNPFLLRSDDVYIDLLTDSGTGAMSDNQWAGIMLGDESYAGSRNYYNLCSAVEHFFGYKLTVPAHQGRGAEQILFPALIERMRQVRGGETPVFISNYHFDTTAGHIELNGGKAINVVTEEAFDTTTPYDWKGNFDLNKLVETIEEHGSKNICAIITTVTCNSSGGQPVSMENMRSVYEIATKYDIPVVIDSARYCENAYFIKQREEGYADKSILEIIREMYQYGDMLTMSAKKDPMVNIGGMCCIRDHQELFQAVQTRCVPMEGFVTYGGMAGRDMEALARGLYEGADEDFLHYRISQVQYLGERLREGGIPIQYPTGGHAVFVDAAKILPHIPADQFPAQALCNALYLEAGIRAVEIGSLLLGRDPETGEQKASELELMRLTIPRRVYTNDHMDYIADALIELKNRAHELKGLMFEYEPPVLRHFTARFREID
What are the official names of this protein?
Tryptophanase, L-tryptophan indole-lyase, TNase.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: OSTA1_CAEEL
Sequence: MEIVKTIIPHNRSYIEPPIPSATEWLANMSVMHVSCLTIACVFVAITFLSSFFHLFFVLKYVSNERIRNDMYALIFMFPITTFASLVGMFIPRAAIFLYAVSLVYFMFTLFIMVTLLFNIFGGRQEMSAYLLQRNIRVNFTVPPLCFFKFLPTVESTDQNLRRIEWLVFQTPIIRTLLELVSVVVSMEQEGRRESVWFVFSQLMALLSMCIAFYGCYVMVPLGREKHAPYRFDFLFRTCDIAQCIYTIQKFVFEFAAAVGLITSDRYLPAAAKALWWASFMCTWEMMLLSALCSYCLRPAKCKFFDLYPGNDMPALSARDGSNSRVPSFSRRLSIEYEPRIAGVMLEPPSRSSLSITPRDKIEDPTTVSYFADNFDSLSQIQGQ
What is the function of this protein?
Probable transporter.
What are the official names of this protein?
Organic solute transporter alpha-like protein 1, Solute carrier family 51 subunit alpha homolog C.
What is the protein family that this protein belongs to?
Belongs to the OST-alpha family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1863_STRPD
Sequence: MTHNHENDHQHEVITLVDEQGNETLFEILLTIDGREEFGKNYVLLVPAGSEEDESGEIEIQAYSFTENEDGTEGDLQPIPEDSDAEWDMIEEVFNSFLDEN
What are the official names of this protein?
UPF0473 protein MGAS10270_Spy1863.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: LGT_ALISL
Sequence: MSQGYLNFPHIDPILFQIGPLAIRWYGLMYLFGFMFALWLANKRADKPNSGWTKDQVSDLLFAGFLGVVIGGRIGYVLFYNFGYFLDNPLYLFEVWTGGMSFHGGLLGVISAMLWYGYKNNRSFFTIADFVAPLVPFGLGAGRLGNFMNGELWGRVTDVPWAMVFPSGGPFPRHPSQLYEFALEGIVLFLILNWFIRKPRPLGAVSGLFLFGYGTFRFLVEYVREPDAQLGLFGDWISMGQILSLPMVIGGLLMMVWAFKRNLYATDLKNSGDKQNSSKQKAK
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYGA_ALIB4
Sequence: MITFSQMLLKLQEFWAKQGCNIVQPYDIPAGAGTFHPATLLRSLDSTPWSTAYVAPSRRPTDGRYGENPNRLGAYYQFQVLIKPSPDNIQDLYLQSLEFLGLDVSKHDIRFVEDNWESPTLGAWGLGWEVWLDGMEVTQFTYFQQVGGLPCSPVAVEITYGTERLAMYLQGVDSVFDIVWNENEFGKTTYADVHKEGEYEFSKYNFEIANTEMLFRHFDDAFNECKSCLGAGLPLPAYDQCMIASHAFNTLDARKAISVTERQNYILKVRELAQGCAVLYKEQESDRLKRVGR
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCCB_DICDI
Sequence: MLKSISLLKNNQILLKNIINNGRIINNVGEKLSSKSLLKINYSSSTTDRTFNILDGTIDKNSAEYKDNLINMNSTLKQLKENIEKIKLGGGEKLNQKNISRGKLLVRERIEALIDVGSPFLEFSQLAGWGMYGKEEVAAGGIITGIGKIHGVECVIVANDSTVKGGTYFPITVKKHLRAQEIAQENNLPCIYLVDSGGANLPRQADVFPDRDHFGRIFFNQANMSAKRIPQIAVVMGSCTAGGAYVPAMADESVIVKGTGTIFLGGPPLVKAATGEIVTSEELGGADLHCRTSGVTDHYARDDAEAIAITRRIVSNLNRKKQPSPVITETEEPLYPTSELAGIVPSDLKKNFDIRKVIARLVDGSRFDEFKELYGTTLICGFARVHGMPVGIIANNGILFSESAVKGAHFIELCNQRGIPLVFLQNITGFMVGKTYESKGIAKDGAKMVMAVATAKVPKITMIIGGSFGAGNYGMCGRSYSPRFLYMWPNAKISVMGGEQAASVLAQIQKDNMAKENKQWSPEEENTFKKPISDKFEEEGSIYYSSARCWDDGVIDPQDSRKVIALSLSACMNQPINPPSDGFGVFRM
What is the function of this protein?
Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
What are the official names of this protein?
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, MCCase subunit beta, 3-methylcrotonyl-CoA carboxylase 2, 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit, 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: ISPS_POPTM
Sequence: MATELLCLHRPISLTHKLFRNPLPKVIQATPLTLKLRCSVSTENVSFSETETETRRSANYEPNSWDYDYLLSSDTDESIEVHKDKAKKLEAEVRREINNEKAEFLTLLELIDNVQRLGLGYRFESDIRRALDRFVSSGGFDGVTKTSLHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLYEASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVSHALELPLHRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRETSRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFSFVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALYNTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTFDDYFGNAWKSSSGPLQLIFAYFAVVQNIKKEEIENLQKYHDIISRPSHIFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDETWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTRKRVLSVITEPILPFER
What is the function of this protein?
Lyase that catalyzes the formation of isoprene from dimethylallyl diphosphate.
What are the official names of this protein?
Isoprene synthase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AZIN2_RAT
Sequence: MAGYLSESDFVMVEEGFSTRDLLEELTLGASQATTGKVAAFFVADAVVRKHFCFLKYLPRVRPFYAVRCNSSLGVLKVLAELGLGFSCASKAEMELVQHIGVPASKIICANPCKQVAQIKYAAKHGVRLLSFDNEVELAKVVKSHPSAKSWGEVLTLDALGLHHTHRRVGCSLMFQASVIASVAQGYLELVCQPFHIGSGCPDPQAYAQSIADARLVFQMGAELGHTMNILDLGGGFPGLEGAKVRFEEVTSVIGKNIPFYTPPPCHVPLRTHATKKMTSSDFCCRVHVTAKEKPLFSPFLTEQTGAAPKSIVYHLDEGVYGVFNSVLFDNTCPTPALQKKPSADQPLYSSSLWGPAVDGCDCVAEGLWLPQLQVGDWLVFDNMGAYTVDTKSLLGGTQACRVTYAMSRLAWEALQGQLLPAEEDQDAEGVCKPLSCGWEITDSLCVGPVFTPASIM
What is the function of this protein?
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake.  AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding.  Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.  Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking.
What are the official names of this protein?
Antizyme inhibitor 2, AzI2, Ornithine decarboxylase-like protein, ODC-like protein, ornithine decarboxylase paralog, ODC-p.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Membrane. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans- Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Note=Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme-dependent manner. Localizes with vesicle- associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN) (By similarity). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules.
Protein: ISOHC_AGEAP
Sequence: IVGGKTAKFGDYPWMVSIQQKNKKGTFDHICGGAIINVNWILTAAHCFDQPIVKSDYRAYVGLRSILHTKENTVQRLELSKIVLHPGYKPKKDPDDIALIKVAKPIVIGNYANGICVPKGVTNPEGNATVIGWGKISSGGKQVNTLQEVTIPIIPWKKCKEIYGDEFSEFEYSQITPYMICAGAEGKDSCQADSGGPLFQIDANGVATLIGTVANGADCGYKHYPGVYMKVSSYTNWMSKNMV
What is the function of this protein?
Peptide isomerase that inverts the chirality at the Ser-81 of omega-Aga IVB.  Acts cofactor-independently.
What are the official names of this protein?
Venom peptide isomerase heavy chain.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
Protein: MINE_RALSO
Sequence: MSILSFLLGEKKKTASVAKERLQIILAHERSSHSAPADYLPALQRELVAVISKYVKIGNDDIKVNLERQDNLEVLEVKIEIPQA
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RK23_GRATL
Sequence: MTKTIKVKKSALIDIIKYPILTDKTTQMIEENKYSFAVEVKAKKPKIKEAIEQLFDVKVQQINTLIVKPQKKRVGKYIGYKSKYKKAVIKLYDPYKINLFADN
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SVIP_HUMAN
Sequence: MGLCFPCPGESAPPTPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQIATSGPPPEGGLRWTVS
What are the official names of this protein?
Small VCP/p97-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the SVIP family.
Protein: PHKR_MYCSJ
Sequence: MTGFRVGVGDGIPAARPAAETMTRANYLGAVANRVDSFWVPDHLNQLFPRSLWKQKYCGATKLIPRVDAVMEPWTMLGHIAARNRAGRLRLGVAVTDSGRRNPAVTAQAAATLHLLTRGRAILGIGPGEREGNEPYGVDWSKPVARFEEAMATIRALWDSGGELVNRDSPFFPLRKAIFDLPPYRGKWPEIWIAAHGPRMLRAAGRYADAYFPSFAHLPTEYAQRLDSVRSAASDVGRDPMAILPAVQMFVVTGSTRDDVDEALDSELLRAFGLNASDDVFTRHGGRHPMGAGFSGAQDLLPHDMDEQTALSHVAVIPPGVTREFLLNGTSDEVIQQAAQWRDCVRYMVLVNVSFLQRNLRKGLMSVKPFNKIVRELKKL
What is the function of this protein?
Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
What are the official names of this protein?
Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase.
What is the protein family that this protein belongs to?
Belongs to the mer family. Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase subfamily.
Protein: SUCC_DESA1
Sequence: MKLYEYEGKEIARKYGIETPRGILATSVEDVDKAYRELNTGTVVLKSQVLVGGRGLAGGVKKASNLEEALTKARELFSMSIKGERVEKILVEEAVCISRELYMSLTVDRATRKLVYLASGMGGVEIEELARKHPDKILRIPVDPFIGYSGYMARHALGFLGLQWDKLGQLDNIMRAMYKIMIDYDAELVEFNPLAYTCDGRLTALDAKIIIDDNSLYRHPDLQPLYGRDATPYEKVAKQLDFNYVELDGDIGVISNGAGLTMATMDSILHYGGRPANFLDIGGGATRERVREAVKIVVTHPRVKAVLVNIFGGITRCDEVASGIVEALSETKVAKPIVVRMLGTNEEEGRRILIEHGITVYTEMDEAVLRIIQLVRGVG
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: ACSA_MYCTU
Sequence: MSESTPEVSSSYPPPAHFAEHANARAELYREAEEDRLAFWAKQANRLSWTTPFTEVLDWSGAPFAKWFVGGELNVAYNCVDRHVEAGHGDRVAIHWEGEPVGDRRTLTYSDLLAEVSKAANALTDLGLVAGDRVAIYLPLIPEAVIAMLACARLGIMHSVVFGGFTAAALQARIVDAQAKLLITADGQFRRGKPSPLKAAADEALAAIPDCSVEHVLVVRRTGIEMAWSEGRDLWWHHVVGSASPAHTPEPFDSEHPLFLLYTSGTTGKPKGIMHTSGGYLTQCCYTMRTIFDVKPDSDVFWCTADIGWVTGHTYGVYGPLCNGVTEVLYEGTPDTPDRHRHFQIIEKYGVTIYYTAPTLIRMFMKWGREIPDSHDLSSLRLLGSVGEPINPEAWRWYRDVIGGGRTPLVDTWWQTETGSAMISPLPGIAAAKPGSAMTPLPGISAKIVDDHGDPLPPHTEGAQHVTGYLVLDQPWPSMLRGIWGDPARYWHSYWSKFSDKGYYFAGDGARIDPDGAIWVLGRIDDVMNVSGHRISTAEVESALVAHSGVAEAAVVGVTDETTTQAICAFVVLRANYAPHDRTAEELRTEVARVISPIARPRDVHVVPELPKTRSGKIMRRLLRDVAENRELGDTSTLLDPTVFDAIRAAK
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.  M. tuberculosis may use AcsA for both acetate and propionate assimilation.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: NUDC_PSEPG
Sequence: MSARWTTAVLDPQITGGLAVARSPDGFLVDANGALFPRDWLKRQDLDVLCEHGIGHFDGQPVFLLELRSATDVPGCSWRGLRAFMLEGDFDTYKVLGYAAQIGTWAREHRFCGSCGQAMTQIRWERAMYCQPCDLRSYPRISPSMIVLVTRGDEILLARSPRFVTGVYSTLAGFAEPGESAEDCLVREVREEVAVEVQNIQYVGSQCWPFPHSMMLGFHAEYAGGDIVMQPDEIEDAQWFSVHDLPPLPAGRSIARYLIDLYVARRLGLPEPVLPR
What is the function of this protein?
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.  The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing.  Has preference for mRNAs with a 5'-end purine.  Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
What are the official names of this protein?
NAD-capped RNA hydrolase NudC, DeNADding enzyme NudC, NADH pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudC subfamily.
Protein: CLPL_STAA8
Sequence: MNNGFFNSDFDSIFRRMMKDMQGSNQVGNKKYYINGKEVSPEELAQLTQQGGNHSAEQSAQAFQQAAQRQQGQQGGNGNYLEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISVDISSLEAGTQYRGAFEENIQKLIEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDEYRNNILKDAALTRRFNEVLVNEPSAKDTVEILKGIREKFEEHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITAAHLSAQSPAVDKVETEKRISELENDKRKAVSAEEYKKADDIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPVSQMDDNDIERLKNISNRLRSKIIGQDQAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKDALIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVINFKNTIIICTSNAGFGNGNDAEEKDIMHEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLDKKGITMDVSQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDIDVEDNELVVKGK
What is the function of this protein?
Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpL.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpL subfamily.