PharMolix/UniProtQA huggingface dataset:
Protein: HPAC_PSEAE
Sequence: MSQLEPRQQAFRNAMAHLSAAVNVITSNGPAGRCGITATAVCSVTDSPPTLMLCINRNSEMNTVFKANGRLCVNVLSGEHEEVARHFAGMTEVPMERRFALHDWREGLAGLPVLHGALANLQGRIAEVQEIGTHSVLLLELEDIQVLEQGDGLVYFSRSFHRLQCPRRAA
What is the function of this protein?
Reductase component of the 4-hydroxyphenylacetate (HPA) 3-hydroxylase.  Catalyzes the reduction of FAD by NADH.  The reduced flavin is then transferred to the oxygenase component HpaB.  Is also able to reduce FMN and riboflavin, but preferentially binds FAD.  Has no activity with NADPH as the reductant.
What are the official names of this protein?
4-hydroxyphenylacetate 3-monooxygenase reductase component, HPA 3-monooxygenase reductase component, FAD reductase (NADH), p-hydroxyphenylacetate 3-hydroxylase small component, HPAH small component.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily.
Protein: NU3C_PIPCE
Sequence: MFLLHEYDIFWTFLIISSVIPILAFLISGVLAPINEGPEKLSSYESGIEPMGDAWVQFRIRYYMFALVFVVFDVETVFLYPWAMSFDVLGVSVFIEAFIFVLIPIVGSVYAWRKGALEWS
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SCM5A_XENLA
Sequence: MSDKPNNFPPLPRFIPLKPCFYQDFDTDIPDLHRTTAKRLYYLWMLNSITLGVNLIGCLAWLIGGGSATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFNFMAFFFTFTAQLVISIIQAVGIPGWGVCGWIASISFFGTNVGSAVVMLIPTIMFTAVAVLSFVALTKVHRFYRGAGGSLSKAQEEWTTGAWKNPHVQQAAQNAAFGATQGAMTQNEPQYSATPNYGYSNEM
What is the function of this protein?
Required for the calcium-dependent exocytosis of signal sequence-containing cytokines.  Probably acts in cooperation with the SNARE machinery (By similarity).
What are the official names of this protein?
Secretory carrier-associated membrane protein 5A, Secretory carrier membrane protein 5 A.
What is the protein family that this protein belongs to?
Belongs to the SCAMP family. SCAMP5 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi- pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity).
Protein: MNHA1_STAAE
Sequence: MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit A1, Mnh complex subunit A1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MCM4B_XENLA
Sequence: MSSPTSTPSRRRNKRGRGSNPPTPHGEEVQSPPSQRRRTEDSTSIGELLPMPTSPSGDVQSPSGQELLFSSPAPSRHSAHQSELDLSSPLTYGTPSSRVEGTPRSGIRGTPARQRPDLGSARKVKQVDLHSDQPAAEELVTSEQSLGQKLVIWGTDVNVATCKEKFQRFVQRFIDPSAKEEDNVGLDLNEPIYMQRLEEINVVGDPFLNIDCDHLRNFDQDLYRQLVCYPQEVIPTFDMAANEIFFERYPDSILEHQIQVRPYNALKTRNMRSLNPEDIDQLITISGMVIRTSQIIPEMQEAFFKCQVCAFTTRVEIDRGRIAEPSVCKHCNTTHSMALIHNRSMFSDKQMIKLQESPEDMPAGQTPHTTILYGHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVRNVKSVYKTHIDVIHYRKTDSKRLHGIDEDTEQKLFTEERVAMLKELAAKPDIYERLAAALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEVNILLCGDPGTSKSQLLQYVFNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVALYYQSEEQMKEEHLDMAVLKDYIAYARTYVNPRLSEEASQALIEAYVSMRKIGSGRGMVSAYPRQLESLIRLSEAHAKVRFSNKVETIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATARKRKEELAQVLKKLIQSKGKTPALKYQQLFEDLRGQSDAAITKDMFDEALHALADDDYLTVTGKTVRLL
What is the function of this protein?
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.  The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
What are the official names of this protein?
DNA replication licensing factor mcm4-B, CDC21 homolog-B, Minichromosome maintenance protein 4-B, xMCM4-B, P1-CDC21-B.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: DAPA_CELJU
Sequence: MIQGSMVALVTPMHADNTLDWDSLHKLVDWHLEQGTHAIVAVGTTGESATLDVQEHLQVIKRVVDQVNGRIPVIAGTGANSTSEAVELTQAAKDVGADACLLVTPYYNKPTQEGLFLHHEYIANAVAIPQYLYNVPGRTGVDMKPETALRLAQVPNIAGIKEATGDLERARLLIDQAPPGFAIISGDDATAVELILLGGQGDISVTANVVPAAIARMCELALAGKAEEARTINTQLLPLHTAMFVESNPIPVKWAVEQLGLIQSGIRLPLTRLSAQYHQQVKTAMQLAGL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_RUEST
Sequence: MNDPIGDMLTRIRNSQMRGKSTVMTPASKLRAWVLDVLQSEGYIRGYESATDERGHPALEISLKYYEGEPVIRELKRVSKPGRRVYMGVNDIPSVRQGLGVSIVSTPKGVMSDANARAANVGGEVLCTVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: CPT2_BOVIN
Sequence: MVARLLLRSWSRGLAVGPGAPCRPLSTGFEPSQYLQRSIVPTMHYQDSLPRLPIPKLEDTIRRYLSAQKPLLDDSQFRKTEQLCKSFETGIGKELHEQLVTQDKQNKHTSYISGPWFDMYLTARDPVVLNFNPFISFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRADLLEPEVFHLNPAKSDTDTFKRFIRFVPSFLSWYGAYLVNAYPLDMSQYYRLFNSTRLPRPHRDELFTDDKARHLLVLRKGHFYIFDVLDQDGNIVSASEIQAHLKYILSDNSPAPEFPLSYLTSENRDIWAELRQRLVSGGNEATLGKVDSAVFCLCLDDFPIRDFVHLSHSMLHGDGTNRWFDKSFNLIIAKDGTAAIHFEHAWGDGVAVLRFFNEVFKDSTQAPAITPQSQPASTDSSVAVQKLNFKLSDALKTGISAAKEKFDATVKSLTIDYIRFQRGGREFLKKQKLSPDSMAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASIFTKTCSEAFVREPSKYSAGELQQMMAKCSTYHNQLTREAAMGQGFDRHLFALRYLAAARGISMPELFLDPAYRQINHNILSTSTLSSPAVNIGCFAPVVPDGFGIGYSVQDNWIGCNVSAYQSRNAREFLQCVEKALEDMFDALEGKMIKT
What is the function of this protein?
Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites.  Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.  Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
What are the official names of this protein?
Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II.
What is the protein family that this protein belongs to?
Belongs to the carnitine/choline acetyltransferase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: HV01_HETFR
Sequence: MRSAISLSLLLVFLSRVQSDIVLTQPEADTGKPEGSLRLTCKTSGFSLGSYYMTWVRQVPGQGLEWLVSYHSSSYQYYAPEIKDRFTASKDTSNNIFALDMKSLKTEDTAMYYCAR
What are the official names of this protein?
Ig heavy chain V region.
Protein: SYT5_HUMAN
Sequence: MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLRPPDRVRLLPAP
What is the function of this protein?
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.  Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells.  Required for export from the endocytic recycling compartment to the cell surface (By similarity).
What are the official names of this protein?
Synaptotagmin-5, Synaptotagmin V, SytV.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment.
Protein: BTRP_NIACI
Sequence: MRLILIRHAQARCNILEDDALMDAYDPHCELTEAGIGQAVKLRDEYPVSLTPSVIYSSPLKRARETAGIFRGRYPSVPFVEDERLSELKAPESFIPPITQGQWDLYLEQRIRSPHLEIVKGLESLDVQRERIERFYKDLFRKYAEEACNIVIFTHAFSIQLSILFFLGLGNEQLLQWQIKASNTAMHIIHYDPTSGSFLLESLNNRSHLQTTG
What is the function of this protein?
Catalyzes dephosphorylation of 5''-phosphoribostamycin to generate ribostamycinin the biosynthetic pathway of butirosin.
What are the official names of this protein?
5''-phosphoribostamycin phosphatase, Butirosin biosynthesis protein P.
What is the protein family that this protein belongs to?
Belongs to the histidine phosphatase superfamily.
Protein: TSR2_MOUSE
Sequence: MAGAAEDVRVLFGAAVRAALEAWPALQIAVENGFGGVHSQEKAEWLGGAVEDYFIANADLELEEIEDFLGELMTTEFDTVVEDGSLPQVSQQLQTMFHHFQKGDGAALQEMTSQINQKKCKVTATPLMTAKETDVAEDDVDSVEEMEVTATNDGATTDEVCPQPQPSDPDTQTIKEEDIVEDGWTIVRRKK
What is the function of this protein?
May be involved in 20S pre-rRNA processing.
What are the official names of this protein?
Pre-rRNA-processing protein TSR2 homolog.
What is the protein family that this protein belongs to?
Belongs to the TSR2 family.
Protein: RMA3_ARATH
Sequence: MEGNFFIRSDAQRAHDNGFIAKQKPNLTTAPTAGQANESGCFDCNICLDTAHDPVVTLCGHLFCWPCIYKWLHVQLSSVSVDQHQNNCPVCKSNITITSLVPLYGRGMSSPSSTFGSKKQDALSTDIPRRPAPSALRNPITSASSLNPSLQHQTLSPSFHNHQYSPRGFTTTESTDLANAVMMSFLYPVIGMFGDLVYTRIFGTFTNTIAQPYQSQRMMQREKSLNRVSIFFLCCIILCLLLF
What is the function of this protein?
E3 ubiquitin-protein ligase.
What are the official names of this protein?
E3 ubiquitin-protein ligase RMA3, Protein RING membrane-anchor 3, RING-type E3 ubiquitin transferase RMA3.
Protein: MNHA1_STAAC
Sequence: MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit A1, Mnh complex subunit A1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MYSM1_XENLA
Sequence: MAEEAADVDIDIEGDINESSKSIYDSLNTGFAPEHYIESAWQNEEGLAPWALDSSISEENREAIKKMLLEEEYYLSNKPLAVKFWSDSQEGEKQCIKRVRSPAKASSSPVKWTKEEKNLFEQGLATFGRRWTSIARLIGSRSVLQVKNYARHYFKNKCKLEGFVKEEAKIGSLQIPNLQDYENEPDITDEPTTFRGRADPNLNAIKIEKLSDDEEIDITDEVDELLSNKTNLDTIIIAKTDKVKETKVETEVQQKSHSTTEHSQTDIPKLVLQQTETECLDSVNPLTCITSPKWTLSPQQCEEDDYDQPDVQDCLQEKCLSPHAEDLTVLCENENDSQDEDDEIKPPDQELEIDRNFILDEEKQAIPEFFEGRQAKTPDRYLRIRNYILDQWENCKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFGCEQAIYNRPRPVDKTKCKEGKDTLEAYKLAHRLQSMRTRKRRVRDPWGNWCDAKDLEGQTYEHLSAEELARRHEDKIKSYKYSKGTRQVRSSFDPFQLIPCSAFSEEKKAPFQVKVSCEAMLVLDLHAHVSMAEVIGLLGGRYTESESVVEICAVEPCNSLSTGLQCEMDPVSQTQASEALASRGYSVIGWYHSHPAFDPNPSIRDIDTQAKYQNYFSRGGAKFLGMIISPYNRRNPHPQSQVACLIISDELSNDGSYRIPYKFEIEYMQGEPQWELVFAKTRWIIEKYRSSHSSVSMDKRFRHDSELTCLQKLLMCMKKTLGNTACPLITEEFLHRIEEYFRTSYKKESNYQIEDNDPCKQHSDTTFTMDSFQDYEPNGRPSL
What is the function of this protein?
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator.  Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes.  Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome.  Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
What are the official names of this protein?
Histone H2A deubiquitinase MYSM1, 2A-DUB, Myb-like, SWIRM and MPN domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. MYSM1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CD033_HUMAN
Sequence: MDFKIEHTWDGFPVKHEPVFIRLNPGDRGVMMDISAPFFRDPPAPLGEPGKPFNELWDYEVVEAFFLNDITEQYLEVELCPHGQHLVLLLSGRRNVWKQELPLSFRMSRGETKWEGKAYLPWSYFPPNVTKFNSFAIHGSKDKRSYEALYPVPQHELQQGQKPDFHCLEYFKSFNFNTLLGEEWKQPESDLWLIEKCDI
What are the official names of this protein?
UPF0462 protein C4orf33.
What is the protein family that this protein belongs to?
Belongs to the UPF0462 family.
Protein: PTTG1_GORGO
Sequence: MATLIYVDKENGEPGTRVAAKDGLKLGSAPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVRMPSPPWESNLLQSPSSILSTLDVELPPVCCDIDI
What is the function of this protein?
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair.  Probably acts by blocking the action of key proteins.  During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes.  At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1.  Its function is however not limited to a blocking activity, since it is required to activate ESPL1.  Negatively regulates the transcriptional activity and related apoptosis activity of TP53.  The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed.  May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity).
What are the official names of this protein?
Securin, Pituitary tumor-transforming gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the securin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TRMB_COLOR
Sequence: MGRARPKSQKRGDYRVSRSQENAAELPKKKFYRQRAHANPFSDHHLVYPACPDEMDWTLYYPAFPTQGETLPNHIFTHNQSCMRISDSTRSGSLQKNIEVVDIGCGFGGLLVALAPLMPETLALGLEIRTSVTEYVQEKIRALRAQNEGTGLYQNIGCIRANSMKFLPNFLRKSQLSKIFICFPDPHFKARKHKARIVSATLNSEYAFALRPGGIVYTITDVEPLHQWMAEHFVAHPSFERLSQEEEEADECVQVMKSETEEGRKVTRNQGQKFVALFRRIEDPPW
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, Appressorial penetration into host protein 1, Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NR1H2_HUMAN
Sequence: MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
What is the function of this protein?
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).  Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).  Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8.  Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).  Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity).  Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity).  Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity).  Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
What are the official names of this protein?
Oxysterols receptor LXR-beta, Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: FIMH_ECOLI
Sequence: MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ
What is the function of this protein?
Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae).  Adhesin responsible for the binding to D-mannose.  It is laterally positioned at intervals in the structure of the type 1 fimbriae.  In order to integrate FimH in the fimbriae FimF and FimG are needed.
What are the official names of this protein?
Type 1 fimbrin D-mannose specific adhesin, Protein FimH.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: RL23_SHEHH
Sequence: MISEERLLKVILAPHISEKSTVNAEKNNTVVFRVAIDATKAEVKAAVAQLFEVEVDSVRTLVNKGKTKRTGARTGRRSDWKKAYVTLAEGADIDFVGGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: YSCM_YEREN
Sequence: MKINTLQSLINQQITQVGHGGQAGRLTETNPLTENSHQISTAEKAFASEVLEHVKNTALSRHDIACLLPRVSNLELKQGKAGEVIVTGLRTEQLSLSDAKLLLEAAMRQDTAADG
What is the function of this protein?
Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.
What are the official names of this protein?
Yop proteins translocation protein M.
Protein: CLPP_BRUA2
Sequence: MRDPIETVMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVNGPVEDGMSMLVCAQLLFLEAENPKKEINMYINSPGGVVTSGMAIYDTMQFIRPPVSTLCMGQAASMGSLLLTAGATGHRYALPNARIMVHQPSGGFQGQASDIERHAQDIIKMKRRLNEIYVKHTGRDYDTIERTLDRDHFMTAQEALEFGLIDKVVEARDVSADESK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.