PharMolix/UniProtQA huggingface dataset:
Protein: TRMD_DESVH
Sequence: MRCTILTLFPEFFDSPLDAGLMGKARESGLIDVALVNPRAYTTDRHSTVDDRPYGGGPGMVMRVEPWEKALQGIEEPGRILMMAPKGRPFTQAMARELAQEESLTILCGRYEGFDARLEEIYPIEAVSMGDFVLNGGETAALAVLEAVSRLVPGFMGKEESGTEESFSAGLLEYPHYTRPEDYAGHVVPEVLRSGDHGRIAAWRKECSLRLTLSQRPDILPEAQLDEADMDFLRGLSRNRPGRNLYCALVHYPVVLKEKNSGATSLTNLDIHDIGRSSCTYGLGGFYVTTPLEDQRRLLDTLLRHWTLGPGSRSNPDRAEALGRIKGVDDVRAAIEDIARRTGQVPYVVGTSAKGAGNATPASVRAMLEERPVLLVFGTGHGLAPEVLEGCDAILRPLRWMDGYNHLSVRAAAAIIMDRLLGDCY
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPC1_SCHPO
Sequence: MKDPIDDQIPKRIKHLQFGINGPEEFVKDGTVEVSRRDLYTMTDRSPAEHGALDLHMGTSNKQINCATCGESMADCMGHFGYVKLALPVFHIGYFKATLTILQNICKDCSSVLLSDQEKRQFLKDLRRPGIDNLRRSQICKRINDHCKKMRRCSKCDAMQGVVKKAGPLKIIHERFRYVRKSQDDEENFRHSFDEALKTIPELKMHLSKAHDDLNPLKVLNLFKQITPVDCELLGMDPEHGRPENLLWRYVPAPPVCIRPSVAQEGATTEDDLTVKITEIIWTSSLIRAALSKGTPISNLMEQWEFMQLSIAMYINSEMPGLRPSDMPSKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDQVAVPYRIAKILTFPERVTTQNKKHLQDCIRNGPDVHPGANYVIDRESGFKRFLRFGNRNRIADDLKIGDIVERHLHDNDVVLFNRQPSLHKLSIMAHLVKVRPWRTLRFNECVCGPYNADFDGDEMNLHVPQTEEAKTEALELMGIKNNLVSPRNGEPIIAATQDFITAAYLLSLKDTFLDRKSISNICCYMMDASTHIDLPPPAIIKPRCLWTGKQVFTVLMKPNRFSKVLVNLDAKTRSFSRIKSKTPEMCPKDGYLMIRNSEIIAGVVDKSVVGDGKKDSLFYVILRDYGALEAAEAITRLSKMCARFLGNRGFSIGIEDVQPGKSLSSQKEILVNKAYATSDDFIMQYAKGILECQPGMDQEATLEAKISSTLSKVRDDVGEICMDELGPANSPLIMATCGSKGSKINVSQMVACVGQQIISGKRVPDGFQDRSLPHFHKNSKHPLAKGFVSNSFYSGLTPTEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSSAYDGTVRSSNSDVVQFVYGDDGLDPTYMEGDGQAVEFKRTWIHSVNLNYDRHDSAMLPYEIIDYVNRALDDPKFLTNCNRDFIETIRTFVIENIAKYLASVRERRDLAPMLEEPDMDDLDDMEGDEFAPVAKRKSVENIIRVTEKQLRSFVDRCWEKYMRAKVEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVAAQTTLGVPRIKEIINAAKTISTPIITGQLINDRDERSARVVKGRIEKTYLKDVTSYIEEVYGPVTTYLSIQVNFDTISKLQLDITLADIAAAIWNTPKLKIPSQQVTVNNTLQQIHVHTSSDGKSSETEVYYRLQTYKRVLPDVVVAGIPTINRSVINQESGKIELFMEGTGLQAVMNTEGIVGTKTSTNHVMEMKDVLGIEAARYSIISEIGYTMAKHGLTVDPRHIMLLGDVMTCKGEVLGITRFGVAKMKDSVLALASFEKTTDHLFNAAARFAKDSIEGISECIVLGKLAPIGTNVFQLIRRTEEEEEQKPKELLFDTPSLHQLEITA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Forms the polymerase active center together with the second largest subunit.  A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III.  A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit rpc1, RNA polymerase III subunit C1, DNA-directed RNA polymerase III largest subunit, RPC158.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HBA_SCICA
Sequence: VLSAADKTNVKASWEKLGGHPGAFGGEALDRMFLSFPTTKTYFHHFDLSPGSSNLKTHGKKVADALANAAGHLDDLPGALSTLSDLHAHKLRVDPVNFKLLSHCLLVTLAAHMPADFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: NDHO_PROMP
Sequence: MTESIPKKPLKKGSLVFIDKSIYDGSVEALASDQDLPSYIFEGPGEILSIKEEYAQVRWRRPVPDVWFKLDQIKEYIVSE
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit O, NAD(P)H dehydrogenase I subunit O, NDH-1 subunit O, NDH-O.
What is the protein family that this protein belongs to?
Belongs to the complex I NdhO subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y6579_METS4
Sequence: MAGHSQFKNIMHRKGRVDAVRSKVFGKLAREITVAAKLGVPDPAMNPRLRAAMLAARAENMPKDNIERAIKKATGGEGENYEEIRYEGYGPGGAALIVEAQTDNRNRTASDVRSAFTKAGGSLAETGAVSFMFDRVGLVAFDAKVADADAMLEAAIEAGADDVKSDESGHEVTCEHGALGEVAKALEARFGEPRRTALVWRPQNTVEVDDETGEKLIRLVEMIEDQDDVQNVFVNFAVSDALMARMQD
What are the official names of this protein?
Probable transcriptional regulatory protein M446_6579.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GBRB_DROME
Sequence: MSDSKMDKLARMAPLPRTPLLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYKWNEGPNSVGVSSEVSLPQFKVLGHRQRAMEISLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSDVVADDLVLLGEE
What is the function of this protein?
Gamma-aminobutyric acid (GABA) receptor voltage channel subunit.
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit beta, GABA(A) receptor subunit beta, Protein cyclodiene resistance.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Note=Localizes to large ventral lateral clock neurons axonal varicosities which are synaptic inputs to ventral lateral neuron dendrites.
Protein: SEM5A_MOUSE
Sequence: MKGACILAWLFSSLGVWRLARPETQDPAKCQRAEHPVVSYKEIGPWLREFRAENAVDFSRLTFDPGQKELVVGARNYLFRLELEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTIRSLSNLTEIHDQISGMARCPYSPQHNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRPARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQGTFFLPELDLIYGIFTTNVNSIASSAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHLAVDVVQGRETLVHIIYLGTDYGTIKKVRAPLSQSSGSCLLEEIELFPERRSEPIRSLQILHSQSVLFVGLQEHVAKIPLKRCHFHQTRSACIGAQDPYCGWDAVMKKCTSLEESLSMTQWDQSIPTCPTRNLTVDGSFGPWSPWTPCTHTDGTAVGSCLCRSRSCDRPAPQCGGWQCEGPRMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGSNVEYHPCNTNACPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKFGGMPCLGPSLEFQECNILPCPVDGVWSCWSSWSKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQTCPESWSEWSDWSVCDASGTQVRARQCILLFPVGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMFHMMAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAALNSSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY
What is the function of this protein?
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs).  Ligand for receptor PLXNB3.  In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 (By similarity).  May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
What are the official names of this protein?
Semaphorin-5A, Semaphorin-F, Sema F.
What is the protein family that this protein belongs to?
Belongs to the semaphorin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL18_BRUMB
Sequence: MASPKETLQRRAARVRRQVKAVANGRPRLSVHRSSKNIYAQIIDDVRGVTLAAASTLDGDLKGKLKTGADSAAAAAVGKLVAERAVKAGVKDVVFDRGAFIYHGRVKALAEAAREGGLSF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CATA_STAEP
Sequence: MSKQDGKLTGLFGAPVSDRENSMTAGRRGPLLMQDVYYLEQISHFDREVIPERRMHAKGSGAFGTFTVTNDITQYTNAKIFSEVGKQTEMFARFSTVSGERGAADLERDIRGFALKFYTEDGNWDLVGNNTPVFFFRDPKLFISLNRAVKRDPRTNMRSAQNNWDFWTGLPEALHQVTILMSDRGMPKGFRNMHGFGSHTYSMYNDKGERVWVKYHFRTQQGIENYTDEEAAKIVGMDRDSSQRDLYNAIENGDYPKWKMYIQVMTEEQAKNHPDNPFDLTKVWYKKDYPLIEVGEFELNRNPENYFLDVEQAAFAPTNIVPGLDYSPDKMLQGRLFSYGDAQRYRLGVNHWQIPVNQPKGVGVENLCPFSRDGQMRFLDNNQGGGPHYYPNNQGIYESQPEHKKPPFPTDGDGYEYNYRQDDDNYFEQPGKLFRLQSEDAKERIFTNTANAMDGVSKDVKVRHIRHCYKADPEYGKGVAKALDIDINQIDLETNQDETYENFK
What is the function of this protein?
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
What are the official names of this protein?
Catalase.
What is the protein family that this protein belongs to?
Belongs to the catalase family.
Protein: VATA_METS3
Sequence: MIIEGKIIKIAGPVIIADGMRGAQMYEMVRVGEQKLIGEIIELEGDTATIQVYEETAGIQPGEVVESTGGPLSVELGPGVMGSIFDGIQRPLELIREESGDFIARGVDAESISKEKKWTFKPVAKVGDKVKGGDVLGEVQETSAVLQKILVPPMIEGELTSIASEGEYTVLEDIAEVATDKGDEKIQMLQKWPVRKGRPYVDKLDPDVPLVTGQRAQDTFFSVAKGGAAAIPGPFGSGKTVTQQQLAKWADADIVIYIGCGERGNEMTEVLTEFPYLDDPKTGNPLMDRTVLIANTSNMPVAAREACVYTGITIAEYYRDQGYDVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVNTIGTTSDVASITVVGAVSPPGGDLSEPVTQNTLRICKVFWALDASLADKRHFPSIDWLQSYSLYVDSIEGWWAENVAADWRETRDQAMILLQKESELQEIVQLVGPDALPEADQATLETTRMLREDFLQQNAFDDIDTYCPPVKQYNMLKTILLFHKEALAAVGRGVPIQNIVALPVKEEIGKMKYIPQDEFAAKCEEIQAAITKQCSEA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: LEPA_POLNS
Sequence: MDLIRNFSIIAHIDHGKSTLADRIIQLCGGLSDREMEAQVLDSMDIERERGITIKAQTAALNYKAKDGKIYNINLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYMALGLGVEVVPVLNKIDLPQADPERAKKEIEDVIGIDASEAVTCSAKTGLGVADVIEEMIARVPPPTGNAEDPLQALIIDSWFDNYVGVVMLVRIVNGTLKPKDKITLMANGSSHLVEHVGVFSPKSVDRPELSAGQVGFVIAGIKELKAAKVGDTVTHSPGQQGRVPASEPLPGFKEVKPQVFAGLYPVESSEYDQLRESLEKLQLNDAALLYEPEVSQALGFGFRCGFLGLLHMEIVQERLERQYGMNLITTAPTVVYQVEQSSGSIISVDNPSKMPEASKINTILEPIVTVNLYMPQEYVGSIITLCVGKRGIQMDMNYLGRQVKLTYELPMAEIVLDFFDKMKSISRGYASMDYEFKEYRPADVVKVDILINGERVDALSVIVHRSNSQSRGREVVAKMRDIIPRQMFDVAIQAAIGSNIVARENVKALRKNVLAKCYGGDISRKRKLLEKQKEGKKRMKQVGNVEIPQEAFLAILQVED
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL4_EDWI9
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALDDVLIVTSEVDENLFLAARNLFKVDVRDVAGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NAGD_STAAC
Sequence: MKQYKAYLIDLDGTMYMGTDEIDGAKQFIDYLNVKGIPHLYVTNNSTKTPEQVTEKLREMHIDAKPEEVVTSALATADYISEQSPGASVYMLGGSGLNTALTEAGLVIKNDEHVDYVVIGLDEQVTYEKLAIATLGVRNGATFISTNPDVSIPKERGLLPGNGAITSVVSVSTGVSPQFIGKPEPIIMVKALEILGLDKSEVAMVGDLYDTDIMSGINVGMDTIHVQTGVSTLEDVQNKNVPPTYSFKDLNEAIAELEK
What is the function of this protein?
Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
What are the official names of this protein?
Acid sugar phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. NagD family.
Protein: NDVA_BRUAB
Sequence: MSLLKIYWRAMQYLAVERTATITMCVASVLVALVTLAEPVLFGRVIQSISDKGDIFSPLLMWAALGGFNIMAAVFVARGADRLAHRRRLGVMIDSYERLITMPLAWHQKRGTSNALHTLIRATDSLFTLWLEFMRQHLTTVVALATLIPVAMTMDMRMSLVLIVLGVIYVMIGQLVMRKTKDGQAAVEKHHHKLFEHVSDTISNVSVVQSYNRIASETQALRDYAKNLENAQFPVLNWWALASGLNRMASTFSMVVVLVLGAYFVTKGQMRVGDVIAFIGFAQLMIGRLDQISAFINQTVTARAKLEEFFQMEDATADRQEPENVADLNDVKGDIVFDNVTYEFPNSGQGVYDVSFEVKPGQTVAIVGPTGAGKTTLINLLQRVFDPAAGRIMIDGTDTRTVSRRSLRHAIATVFQDAGLFNRSVEDNIRVGRANATHEEVHAAAKAAAAHDFILAKSEGYDTFVGERGSQLSGGERQRLAIARAILKDSPILVLDEATSALDVETEEKVTQAVDELSHNRTTFIIAHRLSTVRSADLVLFMDKGHLVESGSFNELAERGGRFSDLLRAGGLKLEDKQPKQPVVEGSNVMPFPVKGAVA
What is the function of this protein?
Involved in beta-(1-->2)glucan export.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity).
What are the official names of this protein?
Beta-(1-->2)glucan export ATP-binding/permease protein NdvA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Beta-(1-->2)glucan exporter (TC 3.A.1.108.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPE_METFK
Sequence: MMQDFHAYPAPAKINLFLHITGRRPDGYHLLQSVFRLLDFGDTVHIRPRADHLIRRTENTPGVPEESDLCIRAATLLQRHSGCKLGADIYVTKRTPMGGGLGGGSSDAASVLLALNQLWHLHLRREELITLGLSLGADVPFFIFGESAWVEGIGEKLQSIQLPQAYYVVITPRIHISTAEIFASKQLTRDTNPTTIAAFLRDLVHNDLETVVRQQHPEVEKCLQWLSRFSKARMSGSGASVFAAFDSQESAEAVLARVNEARELPQFVGCEVSGFCAKGLDQHPLRSFAT
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: T178A_RAT
Sequence: MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRSDPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAVKYHFSQPIRLRNIPFNLTKIIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASVSYDLNRVPKLIYSLPHDVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAHLKSGRDSTV
What is the function of this protein?
Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.
What are the official names of this protein?
Transmembrane protein 178A.
What is the protein family that this protein belongs to?
Belongs to the TMEM178 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NCED2_SOLLC
Sequence: MTSTIANYRVSHSFSPSTSYSLDFTLPSKSISMKNHTTTKTKIHSALLTLPKQNNTPKNQPQFQTSHWNFFQKAAAKALDIVESALVSRELQNPLPKTADPRVQIAGNFAPVPEQSVRHNLPVTGTIPDCINGVYVRNGANPLFEPVAGHHLFDGDGMVHAVTVENGSVSYSCRFTETERLVQERELGHPVFPKAIGELHGHSGIARLLLFYARGVFGLVDHSHGTGVANAGLVFFNNRLLAMSEDDVPYHVQVLPSGDLQTVGRYNFDDQLKSTMIAHPKIDPVSGELFALSYDVVQKPYLKSFKFSPDGEKSPDVEIPLDVPTMMHDFAITENYVVIPDQQVVFKLQEMIKGGSPVIYDKNKKSRFGILPKNAENSENIIWVESAETFCFHLWNAWEEPETDEVIVIGSCMTPPDSIFNECNENLKSVLSEIRLNLKTGESTRRQLLSPSDQVNLEAGMVNRNKLGRKTQFAYLAIAEPWPKVSGFAKVDLSTGEIKKHIYGDKRYGGEPLFLPRNVNSEKEDDGYILAFCHDEKTWKSELQIVNAMTLELEATVKLPSRVPYGFHGTFISSKDLQNQV
What is the function of this protein?
Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity.  Catalyzes the first step of abscisic-acid (ABA) biosynthesis from carotenoids.
What are the official names of this protein?
9-cis-epoxycarotenoid dioxygenase NCED2, chloroplastic, LeNCED2, SlNCED2, Nine-cis-epoxycarotenoid dioxygenase 2.
What is the protein family that this protein belongs to?
Belongs to the carotenoid oxygenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma. Note=Partially bound to the thylakoid.
Protein: FUMC2_BRADU
Sequence: MAKSARTKTARPATRTETDSFGPIEVPSDRYWGAQTERSRQNFRIGTDRMPISLVHALGIVKLAAAQSNRELGLLDQRRASAIIRAAREVIDGSLDDHFPLVVWQTGSGTQTNMNLNEVIANRANELLGGELGAKKPVHPNDHVNMSQSSNDSFPTAMHIAAASRITADLVPALGELLRALRKKEKEFAKIVKIGRTHTQDATPLTLGQEFSGYAAQVESGIARLKVAVKELYPLAQGGTAVGTGLNAKPRFARLFAKHVAGITKLPFTSAANKFEALASNDAYVLAHGAISSVATGLFKIANDIRLLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVCCQVFGNHTAITVAGSQGHFELNVYKPVLAYNMLHSIRLMADAARSFTEHCVSGIRADEKRISELMQRSLMLVTALAPKIGYDNAAKVAKTAHANGTTLKEEALRLGFVTADEFDRLVQPEKMTKPG
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II 2, Fumarase C 2, Aerobic fumarase 2, Iron-independent fumarase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1332_MYCTU
Sequence: MPPVCGRRCSRTGEIRGYSGSIVRRWKRVETRDGPRFRSSLAPHEAALLKNLAGAMIGLLDDRDSSSPSDELEEITGIKTGHAQRPGDPTLRRLLPDFYRPDDLDDDDPTAVDGSESFNAALRSLHEPEIIDAKRVAAQQLLDTVPDNGGRLELTESDANAWIAAVNDLRLALGVMLEIGPRGPERLPGNHPLAAHFNVYQWLTVLQEYLVLVLMGSR
What are the official names of this protein?
Uncharacterized protein Rv1332.
What is the protein family that this protein belongs to?
To M.leprae ML1166.
Protein: KRCC1_RAT
Sequence: MKHSNKPYDSFQDELEDYIKVQKARGLEPKTCFRRMRGEYLESCGYREEFDSRPRYRMFDQRIPSGTNHSYPRSCSSSQTEDRVPQWLPAHDKIRLNSLNYCQFTRDGFSEKPVSLNLSQQEYNCGSYSVESVVHKDLCSGHSTIDPQVSHRQMYQKRKRHLEEGRERQEERPKHERKRSSEEMDLNKHKSIQRKKTKAETETVQDGTEKLKNRKEKKNRDVSSKKEDRKRRKEKKEQGEERTEEEMLWDQSILGF
What are the official names of this protein?
Lysine-rich coiled-coil protein 1.
Protein: KDSD_SHIFL
Sequence: MSHVELQPGFDFQQAGKEVLAIERECLAELDQYINQNFTLACEKMFWCKGKVVVMGMGKSGHIGRKMAATFASTGTPSFFVHPSEAAHGDLGMVTPQDVVIAISNSGESSEITALIPVLKRLHVPLICITGRPESSMARAADVHLCVKVAKEACPLGLAPTSSTTATLVMGDALAVALLKARGFTAEDFALSHPGGALGRKLLLRVNDIMHTGDEIPHVKKTASLRDALLEVTRKNLGMTVICDDNMMIEGIFTDGDLRRVFDMGVDVRQLSIADVMTPGGIRVRPGILAVEALNLMQSRHITSVMVADGDHLLGVLHMHDLLRAGVV
What is the function of this protein?
Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs).  Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity).
What are the official names of this protein?
Arabinose 5-phosphate isomerase KdsD, API, L-API.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GutQ/KpsF subfamily.
Protein: KCNQ4_HUMAN
Sequence: MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
What is the function of this protein?
Probably important in the regulation of neuronal excitability.  May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea.  KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect.  Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
What are the official names of this protein?
Potassium voltage-gated channel subfamily KQT member 4, KQT-like 4, Potassium channel subunit alpha KvLQT4, Voltage-gated potassium channel subunit Kv7.4.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily.
What are the subcellular locations of this protein?
Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells.
Protein: VAB7_CAEEL
Sequence: MQSFDIESLIGVNKVPSLVEMVAASRASSFSPPFEQQHHDPMGVVAAAAAAAAAGRHHPYDNRDDGQMRRYRTAFSREQIGRLEREFAKENYVSRKTRGELAAELNLPEGTIKVWFQNRRMKDKRQRVGGLAWPFPPQMAAYMLNPFAYEMWMKTAAASQFGATGPGNGAYGNNGSSTSPSAAGSLPFLPPLGFPSFLSQNSTKSPSSPHSDDSSKSKNTSSDDDESKPVNFSNSPSSSSPSPYSTD
What is the function of this protein?
Transcription factor (PubMed:28056346).  Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons (PubMed:28056346).  Probably acts by binding to specific promoter elements (PubMed:28056346).  Required for posterior-specific pattern formation in the embryo and may have a role in regulating egl-5 expression (PubMed:8654927).
What are the official names of this protein?
Homeobox protein vab-7.
What is the protein family that this protein belongs to?
Belongs to the even-skipped homeobox family.
What are the subcellular locations of this protein?
Nucleus.