Protein: PERA_EPIFF
Sequence: MDAEPFDEVDEYTTYPSLPASVICPVADTKTRYELSWQPSGHHPQEEGDDCAVVTLVYAAWALMASRMTSSERVVFDTIDGRPDRPAARPLRVLCASSQTVGEYLQALRAHTSSEESYMASPDCKSKRHPTSSTLIATRTSGDAKSSNGTIGNGLPSLAGYPLVLDLQLRGSRLQATAMSDSRCTEPWIVFRLLIRLEYCMKGLHEADSRTRLADIDLMSPDDVEQIWKWNGTLPAAVERCMHDMFEDQVYSQPLALAVDAWDGRLTYKELDELSEKLAGHLIDADVGPEVIVPLCFEKSMWMPIAMLGVLKAGGSFTLLEPSFPEQRLRTIVEKVNASVMISSPSNMSLSSRLLKRVVELDSCSVKSFSAHPSRPRNSQPSSTAMFAVFTSGSTGVPKGAILTHTNYSSALAYQLQPLGFTKDSRVFDFASYAFDVSVHNVFATLTSGACLCIPSDEDRHNDISKVMVDMRVTISHLTPSVTRLIDPDSQPFLKTMVFTGEPLSVDDATRWWGKVDVVNEYGPAECTINTVNSRPISPEAATNIGLPVGVAAWITDPENHQVLVPIGCVGELLVEGPLVGRGYIGDPIKTAASFIQDPKWLLRGVSGHPGRKGRLYKTGDLVRYCADGSLSYLGRKDAQVKIRGQRVHLGDVEHWTQVCMPEAQRVFADVIEPQAISPVPTLAVFVQSPEMGENTATNERPVQIRALRADVQAKLSQHLPSYMVPTVSFWMETLPMTPTGKMDRRMLRRIGSSFSAEQLAQARADRRDGPKRQPTCEMEERMRNIWARVLGMLPQDIHLESNFFHLGGDSIASMRVVAYARRLGIQVMVADVFQHPSLHDLAKNCSQTLARAPEDIPAFSLLGPHFNHALFVQDMSTRYALDPMTIQDAYPCTRLQEGLMFLTSKRPGDYIEQNVLELARDLSLEGLRNAWEQAVKAMPILRTRIAQHNHVGLVQLVLDDTADWDEAKGLEKYLAADRKRSMGLGEPLSRFALVRDEEGTCKWLVWTIHHAIYDGWSIRLVTDAVAEAYGGRSIPQGPQFQAFIKYVQDQDERAAVNYWQRNLQGFDSAPFPPNVPSVDQPVADAAVAHSFATPSGAHGCITTSMLIRAAWALVVGRMANSNDVVFGSTLHGRNAAVNGLDEMVAPTIATIPVRVRFCSTQYVPSYLQAITQEAAEMMPYEQTGLQRIAALSSDAEKACKFQTHVVIQPEDCIPGRSLLGQWRSDSQDQWFSTYALTVEVWLRSDDIFASAMFDSRTIQSWVVTGMLQRLEWTMHQLHHATPSQTLGEINMSSAEDLEQIWQWNERVPEPVNRCIHDLLADQVQARPDSPAICAWDGELTYRKLDELSTRMSHSLLQLGAGFHKGLVPLCFDKSMWTAVAILGVLKAGVGFILLDPHLPEQRMRDIVDQVGSKVIVTCPTREILCSRLAEATVAISWDYFSGQLDWTQQELPSVSPSSTAYVVFTSGSTGTPKGVVVTHANAVSAQHHQLEPMGHTPESRLFDFASYSFDVSISNIVSMLACGGCLCVPSESDRTDDMEKSIVSLRVNALDLTPSTLQLLSPERLPAVRQLTLGGEPLREADVEKWCGKTRICNAYGPSECTPTATINSNAMEPQMATHIGKGAGVVTWIVDADDHDELLPLGCTGELLLEGPLVGRGYFNDSAKTAAAFIEDPKWLLRGSISHPGRQGRLYKTGDLVKYNRDGSLAFVGRKDTQVKVRGQRVEPGEIEAVLRSHESVDGAVVVFHRLTDQELWLAAFVTTREDDGKIPQSQSLAHDETQLKQKRIQAWEEEFEGETYLAIGATEAENIGRDFVGWSSMYDGSEINKVEMNEWLDDTIATMLNGGPAGHVLEIGSGSGMMLFNLANHSLQSYIGVDPAMRAVDFTTKAAKSVPDLADKVNVFKGTAEDIMNLDMPIHSELAVMNSVVQYFPSQDYLFNIIQHLASLGSIKTIFVGDIRSHALHKEFMARRALHIAGKDASREEFSGIMENLLKGEPELLVDPGFFTSLPHRIHGVTHVEILPKRMKATNELSSYRYAAVLHVNSHGEQAKDGRAQDIGADEWIDYVSNGLDRQAVSGLLGTASRVAISNIPYSKTIYEREIVNAVEASKNIPKLERESEWLAAALQASQEHSSLCAFDLAELAQLAGYRVECSWARQYSQRGGLDAVFYCGGSGTDSERRTLFRFPTDHEGRPCHVLSTNPLEQQRKSKLRGDLEQLLRSKLPSYMVPQAIKILDKMPVNHTGKIDRSMLSESLQQKAPPTARKRLPSTAPERAMQQIWSKVLSIESSQIGLDDGFIKLGGNSLSAMKVVSMAREEGIRLEVADMFHHSTTSIAHLLQTAAAGVSESGAALPGVTSDRLLSDLARYDCTIAMAQSEAANKRLSATSHGGIRDTRLTVVLTGANGFIGTQILRQLLDHGRFSRVIAIVRGTSASKARQRAIDAAKNAQWWSEFYSSELEVWRGDLALPRLGLGKENWNTLADGTVDVFIHNGASVHFMKSYSALQAANVESTAQVLRVAAENPSMRVVYVSSARCCDPELEREEDVAKALADRPNGYTTTKFIAEALVKRAAARGLGRRDQFAVVSPGLVVGTPTEGVANADDWLWRMTAACIRVGVVNGEESDNWIPIADAAATATTVIETSLGRSSGIVTQVKGGLTMGEFWETLRAIGYTLRGEDSSTCMAAIRQDVEKNRDTHPLGALSDMLQDLADTARSQWADSWRTGGLSSPARLKLALVKSAGFLSKVGVLPLPDGNDEPAQARENLRAFTRSGG
What is the function of this protein?
Nonribosomal peptide synthase; part of the gene cluster that mediates the biosynthesis of peramine, a pyrrolopyrazine synthesized in association with the grass host that protects the plant from insect herbivory (PubMed:16091042).  The single multifunctional NRPS perA seems to be responsible for all catalytic steps in the biosynthesis of peramine (PubMed:16091042).  The condensation domain of perA is proposed to catalyze formation of a peptide bond between 1-pyrroline-5-carboxylate and arginine (PubMed:16091042).  The methylation domain of perA would catalyze the N-methylation of the alpha-amino group of arginine (PubMed:16091042).  The reductase domain is proposed to be responsible for reduction of the thioester and the cyclization to form an iminium ion resulting in release from the peptide synthetase (PubMed:16091042).  Deprotonation of this intermediate and oxidation of the pyrroline ring would give rise to peramine (PubMed:16091042).  This final oxidation to give the pyrrole functionality may be spontaneous (PubMed:16091042).
What are the official names of this protein?
Peramine synthetase, Nonribosomal peptide synthase perA, NRPS perA, Peramine biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.