PharMolix/UniProtQA huggingface dataset:
Protein: TSAC_SALAR
Sequence: MNNNLPTGSIAAAVDLLNKENVIAYPTEAVFGVGCDPDSETAVTRLLELKQRPVDKGLILIAASFEQLKPYIDDSILTTAQRKAVFDCWPGPVTFVFPASATTPRWLTGRFDSLAVRVTDHPLVVALCNAYGKPLVSTSANLSGLPPCRTVEEVRAQFGDDFPMVEGATGGRLNPSEIRDALTGELFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_CRUGL
Sequence: MSPQTETKAGVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEERGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEEEQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTTLSHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDYIEKDRSRGIYFTQDWVSLPGVIPVASRGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAAEGGEIIREACKWSP
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y1850_BURO0
Sequence: MLKGNLAGLMKQAQQMQENMKKMQEQLALIEVEGQSGAGLVKVTMTCRNEVRRVSIDPSLLADDKDMLEDLVAAAFNDAVRKAEATSQEKMSGMTSGLPLPPGFKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Bcenmc03_1850.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
Protein: BPPI_STRP6
Sequence: MEESMDAKLKYKAKKIKMVFFDIDDTLRVKDTGYMPESIQRVFKALKAKGILVGIASGRARYGVPQEVQDLHADYCVKLNGAYVKDDAKTIIFQAPIPADVVVAYKKWADDMGIFYGMAGRHEAVLSARNDMISNAIDNVYAQLEVCPDYNEYHDVYQMWTFEDKGDGLQLPAELAEHLRLVRWHDNSSDVVLKGTSKALGVSKVVDHLGLKPENILVFGDELNDLELFDYAGISIAMGVSHPLLQEKADFITKKVEEDGILYALEELGLIDKELQFPQLDLENHTGPKVTIKTNHGDMTLVLFPDHAPKTVANFLGLAKEGYYDGIIFHRIIPEFMIQGGDPTGTGMGGQSIYGESFEDEFSDELYNLRGALSMANAGPNTNGSQFFIVQNSKIPYAKKELERGGWPTPIAAAYAENGGTPHLDRRHTVFGQLVDETSFQVLDLIAGVETGAQDKPKEDVIIETIEVFD
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
Protein: CLPP_CLOK5
Sequence: MSLVPVVVEQTNRGERSYDIYSRLLKDRIVMLSEEVNDVTASLIVAQLLFLEAENPDKDIYFYINSPGGSITAGMAIYDTMQYIKSDVSTICIGMAASMGAFLLAAGEKGKRFALPNSEIMIHQPLGGFQGQATDIGIHADRILRIKKKLNAIISERTGQSIEKVEKDTERDNFMTAEEAKEYGLIDEVFTKKK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROA_ACISJ
Sequence: MNALNIAEYTHTLGLQAKTASAQMARAPAAIKNKALLALARLLRQNVDALQGDNARDLERARAAGLAEPMVDRLKLTPKVLETCAQGCEQLAAMPDIIGEIQGMKQQPSGIRVGQMRVPIGVFGMIYESRPNVTIEAASLSIKSGNACILRGGSEAIDSNKALARLVAQALAEAGLPEHGVQLVQTTDRAAVGQLIAMPQYVDVIIPRGGKGLIERISAEAKVPVIKHLDGNCHTYVDDPCDIAMAVQVADNAKTQKYSPCNASEGLLVARGVAAQFLPQIGAVYAAKGVEMRGCPEALAILRAVPGVQLAEATEADWSEEYLAPIISVKVVAGVDEAIAHINRYGSHHTDAILTRDHMHAQQFLRDVDSASVMVNASTRFADGFEYGLGAEIGISTDKFHARGPVGIEGLTSLKWVVLGEGEVRT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VFH33_ASFP4
Sequence: MAGRVKIKQKELIDSTVKNKNVMNLFHEIIGSKGNINFSVVWPKFKKIKQSVYDYISTLSVLEKASVMQNFEDDKKLLELFVQKLWAAYEGYFKYPEIEKYEVEGQVNFNLVPQYVLEKFSQLYRIRINSELVTLILNSCAFMSKYNDYILKKDPYILTITPGLCFSPIPNFEDLNFKHLYNSDKNSQHDKDFIMFILYKLYTAALGVYNAISIPDIDVEDLENIILSSVSQIKKQIPRCKDAFNKIESSVHLLRKNFNTYYSDYVGSGYNPTIIMEQYIKDISQDSKNISPRISYQFRTIIKYYRDMIATKHQTMDPQVLNLVKHVEKKLDMLDREKN
What are the official names of this protein?
Protein H339R, pH339R, Protein j4R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus H339R family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: BMNL4_BOMOR
Sequence: GIGAAILSAGKSIIKGLANGLAEHF
What is the function of this protein?
Has antimicrobial activity, but no hemolytic activity.  Preference on killing Gram-negative non-enteric bacteria.
What are the official names of this protein?
Bombinin-like peptide 4, BLP-4.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK7_HUMAN
Sequence: MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILDN
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.  Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).
What are the official names of this protein?
Nucleoside diphosphate kinase 7, NDK 7, NDP kinase 7, nm23-H7.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: NUOB_PSEF5
Sequence: MQYNLTRIDPDAPNDQYPIGERETVSDPLEDQVHKNIFMGKLEDVLSGAVNWGRKNSLWPYNFGLSCCYVEMTTAFTAPHDIARFGAEVIRASPRQADFMVIAGTCFIKMAPIIQRLYEQMLEPKWVISMGSCANSGGMYDIYSVVQGVDKFLPVDVYVPGCPPRPEAFLQGLMLLQESIGQERRPLSWVVGDQGVYRAEMPSQKEQRREQRIQVTNLRSPDEV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: UTY_MOUSE
Sequence: MKSYGLSLTTAALGNEEKKMAAEKARGEGEEGSFSLTVEEKKALCGLDSSFFGFLTRCKDGAKMKTLLNKAIHFYESLIVKAEGKVESDFFCQLGHFNLLLEDYSKALSSYQRYYSLQTDYWKNAAFLYGLGLVYFYYNAFQWAIRAFQEVLYVDPNFCRAKEIHLRLGFMFKMNTDYESSLKHFQLALIDCNVCTLSSVEIQFHIAHLYETQRKYHSAKAAYEQLLQIESLPSQVKATVLQQLGWMHHNMDLIGDNTTKERYAIQYLQKSLEEDPNSGQSWYFLGRCYSCIGKVQDAFVSYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGILYESCNQPQDAIKCYLNAARSKSCNNTSALTSRIKFLQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQSVSDTWNSVQTASHHSVQQKVYTQCFTAQKLQSFGKDQQPPFQTGSTRYLQAASTNDQNQNGNHTLPQNSKGDAQNHFLRIPTSEEQKIINFTKESKDSRSKSLTSKTSRKDRDTSNICVNAKKHSNHIYQISSVPISSLNNKESVSPDLIIVDNPQLSVLVGETIDNVDHDIGTCNKVNNVHLAIHKKPDNLSASSPSSAISTETLSLKLTEQTHIVTSFISPHSGLHTINGEGHENLESSASVNVGLRPRSQIIPSMSVSIYSSSTEVLKACRSLGKNGLSNGHILLDICPPPRPPTSPYPPLPKEKLNPPTPSIYLENKRDAFFPPLHQFCINPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHIVEVRTQLLQPADENWDPSGTKKIWRYENKSSHTTIAKYAQYQACSFQESLREENERRTQVKDYSDNESTCSDNSGRRQKAPFKTIKCGINIDLSDNKKWKLQLHELTKLPAFVRVVSAGNLLSHVGYTILGMNSVQLCMKVPGSRIPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNITWNVGPLTAFQYKLAVERYEWNKLQSVKSVVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKHCQTLREALVAAGKEVLWHGRINDEPAPYCSICEVEVFNLLFVTNESNSQKTYIVHCQNCARKTSGNLENFVVLEQYKMEDLIQVYDQFTLAPSLSSAS
What is the function of this protein?
Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3.  Has relatively low KDM activity.
What are the official names of this protein?
Histone demethylase UTY, Male-specific histocompatibility antigen H-YDB, Ubiquitously transcribed TPR protein on the Y chromosome, Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein, [histone H3]-trimethyl-L-lysine(27) demethylase UTY.
What is the protein family that this protein belongs to?
Belongs to the UTX family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYT_MYCSK
Sequence: MSTAASPAPAAPIRVAAGTTAGAAVRDAGLPGRGAPDAIVVVREADGRLRDLSWTPDADVEVVPVPADSEDGRSVIRHSAAHVLAQAVQDLFPEAKLGIGPPITDGFYYDFDVPRAFTPEDLEALEKKMRKIVKDGQLFERRVYESEEEARRELANEPYKLELVDDKSGDPEVMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTKYIPAFKLTRSSAAYWRGDQTNASLQRIYGTAWESQEALDRHLELIEEAQRRDHRKLGVELDLFSFPDELGSGLPVFHPKGGIVRKELEDYSRAKHLQAGYEFVNTPHITKEQLYVTSGHLEWYADGMFPAMHIDAEYDADGAVRKPGQNYYLKPMNCPMHHLIYRSRGRSYRELPLRLFEFGSVYRYEKSGVVHGLTRVRGMTQDDAHIYATREQMRDELTSLLQFVLDLLSDYGLDEYYLELSTKDPDKYVGSDEIWDEATETLREVAEASGLDLVPDPGGAAFYGPKISVQVKDALGRNWQMSTIQLDFNMPERFELEYTAADGSRQRPVLIHRALFGSIERFFGVLTEHYAGAFPAWLAPVQVVGIPVADAHIPYLEDVAAQLRSRGVRVEIDGSDDRMAKKIVNHTNQRVPFMLLAGDKDVAAGAVSFRFGDRTQINGVPRDEAVEAIVGWIVERRNTAPTADLVKAGAGT
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_STRMU
Sequence: MKVKLITVGKLKEKYLKDGIAEYCKRLKRFTKFELEELPDEKIPNNASQAQNTYILEKEGQRILNKISNREFVIVLAIEGKQFSSEKFSQLLSATMLKGYSDLTFVIGGSLGLSQEVKKRASILMSFGLLTLPHQLMRLVFVEQIYRAFMIQEGSPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAF1_HUMAN
Sequence: MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
What is the function of this protein?
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation.  RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2).  The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'.  Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation.  Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity.  Phosphorylates TNNT2/cardiac muscle troponin T.  Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1).  Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death.  Regulates Rho signaling and migration, and is required for normal wound healing.  Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN.  Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
What are the official names of this protein?
RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf, Raf-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Protein: DPH5_ASHGO
Sequence: MLFLVGLGLSSHEDITVRGLNAVKRCARVYLEHYTSILMTASKEELEGFYGKPVVLADREMVESGCEEILRDADKEDVAFLVVGDPFGATTHTDLVLRAKKQGIVVEVVHNASVMNAVGSCGLQLYNFGQTISMVFFTDSWRPDSWYDKVLENRRIGLHTLVLLDIKVKEQSPENLARGRLIFEPPRYMSISQCCEQLLEVEEKRGQQAYTPDTPCVAISRLGAPTQHMKSGSIHELAEYDAGEPLHSLVILGRQCHELELEYLLEFSEDQERFKDQVHRDQEFFKPAPWVPPPEDED
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester.  The four successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine methyl ester synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_METTH
Sequence: MVPVEDLVYRYALLNAVKHRGRANPGAVMGAVMSNEPELRKMAPQVKEAVEAAVERVNSLSPEEQQQEMERLGLEITERKQKKRKGLRELAGVKGEVVLRFAPNPSGPLHIGHARAAILNHEYARKYDGRLILRIEDTDPRRVDPEAYDMIPADLEWLGVEWDETVIQSDRMETYYEYTEKLIERGGAYVCTCRPEEFRELKNRGEACHCRSLGFRENLQRWREMFEMKEGSAVVRVKTDLNHPNPAIRDWVSMRIVEAEHPRTGTRYRVYPMMNFSVAVDDHLLGVTHVLRGKDHLANREKQEYLYRHLGWEPPEFIHYGRLKMDDVALSTSGAREGILRGEYSGWDDPRLGTLRAIARRGIRPEAIRKLMVEIGVKIADSTMSWKKIYGLNRSILEEEARRYFFAADPVKLEVVGLPGPVRVERPLHPDHPEIGNRVLELRGEVYLPGDDLGEGPLRLIDAVNVIYSGGELRYHSEGIEEARELGASMIHWVPAESALEAEVIMPDASRVRGVIEADASELEVDDVVQLERFGFARLDSAGPGMVFYYAHK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CXCL3_MOUSE
Sequence: MAPPTCRLLSAALVLLLLLATNHQATGAVVASELRCQCLNTLPRVDFETIQSLTVTPPGPHCTQTEVIATLKDGQEVCLNPQGPRLQIIIKKILKSGKSS
What is the function of this protein?
Ligand for CXCR2.  Has chemotactic activity for neutrophils.  May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion.
What are the official names of this protein?
C-X-C motif chemokine 3, Dendritic cell inflammatory protein 1.
What is the protein family that this protein belongs to?
Belongs to the intercrine alpha (chemokine CxC) family.
What are the subcellular locations of this protein?
Secreted.
Protein: JBP1_LEIBR
Sequence: MESSTKRIKMDIFNFPTIKETRTPEEVAESYAEAVKLHPFYDNAHCVIDFYDSGTIKDGRGEIIGVVLRKALPKYATSMASALLISAAVRTSLRSMIFGGESPLSGIAGYFDYRGSPVELKSRKTSFTYEHEEAWSAVFPVVDYVSEIYRHVAPERWKAQNNAIPDLVRIHGTPFSTLTINSRFRTASHTDVGDFDAGYSCIACIDGKFKGLALTFDDFRINVLMQPRDVMVFDSHHFHSNTEVEVSCSEEDWKRLTCVFYYRTALGEPSSYAEYRRRLEKSKQDPSFTPVVSNVMMKENGTNLNRPSPVHPVPPSPFWLPMLAHCLQHCASAAQSVHEAMTADGSQLAEIIFGEPLSTSDGIPLRGDDEKLKANGDTGAKPLSRLGGFSETDLMVSTAAEKRKYLDSEFLSHCISAQLLDMWKQARARWLELVGKEWKHMLTLNPERKDFLWKNRSEMNSAFFDLCEVGKQVMLGLLDKEAALPKEEQAFWTMYAVHLSAACAEELHMPHDAMSLRKLNVKLKDFNFGGTRYFKDMPPEEQQRRMERKQRIEEARRHGMTGAHEKRANWLTNDSFDYQTEDCVVDYAKHKWVLPERHAKAVTKNVHTAWLPTREEVVRVLVVLPDLQIRVEGVDCKLEKPDTVEDSSEWVRLVSSPAVHRLLAAAQRNLQLPDDVMHGNIHIRFVFHSTLPTDMYDFVVLQHVLSRIPDDVLASSYITRAAALCSGCLFVEETDVQCRQYYTLKYSIRRNYDAVAPHFFQQLHQASYGTKMARVRTKGELEALIPTVCCARYKLQGSPLNTTIHVVSPTAPH
What is the function of this protein?
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU).  DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation.  Also specifically binds to base J-containing DNA (J-DNA).  Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis.  Thymine dioxygenase activity and J-DNA-binding are independent functions (By similarity).
What are the official names of this protein?
Thymine dioxygenase JBP1, J-binding protein 1, Thymidine hydroxylase JBP1.
What is the protein family that this protein belongs to?
Belongs to the TET family. JBP1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PYRR_STRS7
Sequence: MKSKVIVDELTMKRAITRITYEIIERNKQLDNVVLVGIKTRGVYLARRIQERLEQLESLHLAVGELDTKPFRDDMRVEEDTTSMPVDITGKDIILVDDVLYTGRTIRAAIDNLVSLGRPGRVSLAVLVDRGHRELPIRADYVGKNIPTSKTEEIVVEVVEVDGQDRISIVDPG
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: RECR_GEOSW
Sequence: MHYPEPISKLIDSFMKLPGIGPKTAIRLAFFVLTMKEDTVLEFAKSLVDVKRNIRYCTVCGHITDTDPCYICKDERRDRTTICVVQDPKDVIAMEKMKEYNGLYHVLHGAISPMEGIGPEDIKIAELLKRLQDEAVQEVILATNPNIEGEATAMYISRLLKPTGIKVTRIAHGLPVGGDLEYADEVTLSKALEGRREL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: INSI2_HUMAN
Sequence: MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE
What is the function of this protein?
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062).  Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062).  Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:26160948, PubMed:17428920, PubMed:32322062).  In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062).  Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062).  Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767).
What are the official names of this protein?
Insulin-induced gene 2 protein, INSIG-2.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.