PharMolix/UniProtQA huggingface dataset:
Protein: GRPE_WOLTR
Sequence: MSDSSKERKKKFTGMVNKQKSEDQQNNSKQADDLDELKTLKERAVQLEDHLRRAVADNENVKRIMQKQISDANDYAVTKFARDMIDSCDNLKRVMEILKDDDPVHEGIKVAYKKIMNDLKKHGIEEIDPIGELFDSNLHQAVVEREDNEKKTGTIVEVLQTGYTIKNRLLRPAMVIISKKNC
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT1_SUIBO
Sequence: MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAFYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGFALPHAILRLDLAGRDLTDHLIKNLIERGYSFTTTAEREIVRDIKEKLWYVALDFEQEIKTAGQSSALEKSCELPDGQVITIGNERFRAPEALFQPAFLGLEAAGIHETTYNSIFKCDLDIRRDLYANVVLSGGTTMFPGIADRMQKELTSLSPSSMKVKIVAPPERKYSVWIGGSILASLSTFQNLWCSKQEYDESGPGIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin-1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GCST_GEOSW
Sequence: MLKRTPLFAVYERYGAKTIDFGGWELPVQFSSIKEEHEAVRTRAGLFDVSHMGEFVVKGDDSLAFLQKMMTNDVSKLTDGRVQYSLMCYEDGGTVDDLLIYKKADGHYLLVVNAANIEKDFEWLHGHLFGDVELVNISQEIAQLALQGPLAEQVLQKLTNTDLSAIKFFSFQDDININGVKALVSRTGYTGEDGFEIYCRREDAVALWESILEAGKEEGVLPCGLGARDTLRFEATLPLYGQELSKDITPIEAGLGFAVKTNKDADFIGKDVLKKQKEEGTARKLVGIEMIDKGIPRHGYKVFANGEEIGFVTTGTQSPTLKKNIGLALIKTEFTEMDTEVEVEIRGKRLKAKVIATPFYKRAK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MAP1_BOVIN
Sequence: MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDIAAGLIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGDVDEGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYSKNKAVGVMKAGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSAQPHFMSQF
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQSC_PSEAE
Sequence: MHKVKLAAITCELPARSYENDDPVFAAVPDLSESWWQFWGVNRRGYFDPRNGENEFSLVVRAAERLLRSSDTAPDSVDMLICSASSPIMTDAGDVLPDLRGRLYPRMANVLSKQLGLSRALPLDSQMECASFLLNLRLAASMIRQGKAEKVLVVCSEYISNLLDFTSRTSTLFADGCAVALLTRGDDDSCDLLASAEHSDATFYEVATGRWRLPENPTGEAKPRLYFSLFSDGQNKMASFVPTNVPIAMRRALEKAGLGSDDIDYFVFHQPAPFLVKAWAEGIGARPEQYQLTMGDTGVMISVSIPYTLMTGLREGKIRPGDRIVMAGAATGWGFAAQVWQLGEVLVC
What is the function of this protein?
Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence.  The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ.  First, PqsC acquires an octanoyl group from octanoyl-CoA and forms an octanoyl-PqsC intermediate.  Then, together with PqsB, it catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and resulting in closure of the quinoline ring.
What are the official names of this protein?
2-heptyl-4(1H)-quinolone synthase subunit PqsC.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PABP_YARLI
Sequence: MTLENKAEASPATKEETTTEAAPAEGEAKTESSEEKGSKEDQGDNASLYVGELDPSVTEAMLFEIFNPIGPVTSVRVCRDAITRRSLGYAYVNFHNQADGIRALEELNYSPIKERPCRIMWSQRDPALRKTGAGNIYIKNLDPAIDNKALHDTFSAFGQILSCKIATDEFGNSRGFGFVHYESAESAESAIQHVNGMLLNDKKVFVGPHVPKSDRMQSFEEQKNSFTNVFIKNLGTEITEAEFEELVNKFGETSSVHLSTNDEGKPTGFGFVDYKEHDVAVKAIDGLSETEFKGNKLFAGRAKKKYERADELRKQYEASRLEKLNKYQGVNLYIKNLDDTIDDDKLRAEFAPHGTITSAKVMVDEAGKSKGFGFVCYSSPEEATKAVTEMNHRLVAGKPLYVVLAQRKDVRRSQLQQQIQAKNQMRLQQQAAAGGLPGQYMGNPGVFYPGQPGFMPPGRGGMPFGANPQMMMRPPMPPQNQFPPRGVPGGPNMYGAPPQGYQQGGFPPQGPMRGGQPPRSGQPGPQGQFRGAPRRKDGESRVADSISNALENAPEEQHKQLVGEALYPKVLAEKAIDGNAEFAGKITGMLLEMPIKEILEVIDDEEGLQAQINDAITAYNEYLNSQKEE
What is the function of this protein?
Binds the poly(A) tail of mRNA.  Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation.  In the nucleus, involved in both mRNA cleavage and polyadenylation.  Is also required for efficient mRNA export to the cytoplasm.  Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation.  In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
What are the official names of this protein?
Polyadenylate-binding protein, cytoplasmic and nuclear, PABP, Poly(A)-binding protein, Polyadenylate tail-binding protein.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding protein type-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DAPA_ACISJ
Sequence: MTSPSAPLTGSIVALVTPMHDDGSVDYPALRKLIDWHIAEGTDCIGVVGTTGESPTVNVEEHCEIIRVSVEQAAKRVPIMAGCGANSTAEAIELARFAKKVGADSQLQVVPYYNKPTQEGQYRHFKAIAEAVGDLPMVLYNVPGRSVADMQHETVLRLTQVPGIVGIKEATGNIERAQWLIRDVPKGFAVYSGDDPTAVALMLCGGQGNISVTANVAPRLMHELCVAALAGDTRRAMEIQFRLMPVHKQLFVEANPIPVKWAVQRMGLCGGALRLPMTPLSQGNEAVVEAALRAAGLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_RHILO
Sequence: MFNLLLVVVGGGIGAGIRHLTNMGALRLVGPNYPWGTMAINIVGSFAMGLFIAILARRGGSNEVRLFVATGIFGGFTTFSAFSLDFATLWERGATLPAFGYALASVIGAIIALFLGLWLARSLP
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RBOHJ_ARATH
Sequence: MKNNKKVGTEDSTKWMLESVEIDPKGDSSVKQPESTINSNNPESSGAGGGILKNVSKNLAVGSIIRSMSVNKWRKSGNLGSPSTRKSGNLGPPLPVSQVKRPGPQRVERTTSSAARGLQSLRFLDRTVTGRERDSWRSIENRFNQFAVDGRLPKDKFGVCIGMGDTLEFAAKVYEALGRRRQIKTENGIDKEQLKLFWEDMIKKDLDCRLQIFFDMCDKDGDGKLTEEEVKEVIVLSASANRLVNLKKNAASYASLIMEELDPNEQGYIEMWQLEVLLTGIVSNADSHKVVRKSQQLTRAMIPKRYRTPTSKYVVVTAELMYEHWKKIWVVTLWLAVNVVLFMWKYEEFTTSPLYNITGRCLCAAKGTAEILKLNMALILVPVLRRTLTFLRSTFLNHLIPFDDNINFHKLIAVAIAVISLLHTALHMLCNYPRLSSCPYNFYSDYAGNLLGAKQPTYLGLMLTPVSVTGVLMIIFMGISFTLAMHYFRRNIVKLPIPFNRLAGFNSFWYAHHLLVIAYALLIIHGYILIIEKPWYQKTTWMYVAIPMVLYASERLFSRVQEHNHRVHIIKAIVYSGNVLALYMTKPQGFKYKSGMYMFVKCPDISKFEWHPFSITSAPGDEYLSVHIRALGDWTSELRNRFAETCEPHQKSKPSPNDLIRMETRARGANPHVEESQALFPRIFIKGPYGAPAQSYQKFDILLLIGLGIGATPFISILKDMLNNLKPGIPKTGQKYEGSVGGESLGGSSVYGGSSVNGGGSVNGGGSVSGGGRKFPQRAYFYWVTREQASFEWFKGVMDDIAVYDKTNVIEMHNYLTSMYEAGDARSALIAMVQKLQHAKNGVDIVSESRIRTHFARPNWRKVFSELSNKHETSRIGVFYCGSPTLVRPLKSLCQEFSLESSTRFTFHKENF
What is the function of this protein?
Calcium-dependent NADPH oxidase that generates superoxide.
What are the official names of this protein?
Putative respiratory burst oxidase homolog protein J, NADPH oxidase RBOHJ, AtRBOHJ.
What is the protein family that this protein belongs to?
Belongs to the RBOH (TC 5.B.1.3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: METJ_YERPA
Sequence: MAEWNGEYVSPYAEHGKKSKQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPNDEDLRKERSDEIPEAAKILMRELGVDPDTWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_PECAS
Sequence: MKPTTISHLRQWKQEQRKFATITAYDASFSRLFFEQGIRVMLVGDSLGMTVQGHDSTLPVTTHDIVYHTQCVRRGAPLALVLSDMPFMTYATPEQTFSQAAELMRAGANMVKLEGGSWLAPTVKMLTERAVPVCGHLGLTPQSVNIFGGYKIQGRSESDANQLLADALALEEAGAQLLVLECVPVALAKRVTEALSIPVIGIGAGNVTDGQILVMHDALGITGDSTPKFAKNFLAQSGDIRTAVRLYSQEVEQGIYPAEEHSFH
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_HELPS
Sequence: MDAEIFSLDSLSIYKDINIASAKPSLKERKNIKHYALDYLSIDEKNNAPLFKTLLEDAMRVSSKEVLLIVGGSSFYLKSILEGLSDTPKISGEEAVKIEQEINSLANPYAFLKSIDPTSAFKIHPNDTYRIHKALEIFYSTHTPPSEYFKTNPKKPFEHAISLFALSIEKSALANNIKQRTKNMLDCGLIEEIKALYAQYPKDSQPFKAIGVKESILFLEKQLTLKKLEEAIISNTIQLAKRQNTFNKTQFNNLYTGSVGEVRHAILNHSKSAIKG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: TRHO_PSEAB
Sequence: MTSIVVAALYKFVTLDDYVALREPLLQTLLDNGVKGTLLLAEEGINGTVSGSREGIDALFAWLRSDPRLADIEHKESYCDEQPFYRTKVKLKKEIVTLGVLGVDPNKQVGQYVEAKDWNALISDPEVLLIDTRNDYEVAIGTFEGAVDPKTRSFREFPEYIKAHYDPARHKKVAMFCTGGIRCEKASSYMLGAGFEEVFHLRGGILKYLEEVPQEQSLWRGDCFVFDNRVTVRHDLSEGEYDQCHACRNPVSLEDRQSEHYVPGISCPHCWDSLSEKTRAGARERQKQIELARQRNQPHPLGRDPRQSTLEN
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: PPK6_SCHPO
Sequence: MSQDVFKHLTSKQVQRTRARSFGASFERPLASFLPKKENKNLLSNAARVKLLTFSSSSPYSFSYSPVLSRDANDGYIPLDTSSRANLWESVTDYDLQHANEPLVGNYYISTEALGDGLNRSPFTINPEKRRSLSDISYVPIPHKEHSNWPVHCSSQAIVTTSNTTFSIWSANDYFCLLFGYAGSQLNRHSVFDIFPKSFSSHLSNLIVSFPIDNEHERILFCGDVFPVITVDGVRLMDFWVKEKQGKLIWILEFVEESYIDIKLQDGVAVDERTEQPLTSDLLPSRLPKTWDQRLYLTTKTTEGYYCPSMIYPLSKSSFQYIIFHYAAGLLFINSDFKIISLNEALFESMLGYSDLLTKDISLIFPDFKLVLQQLADSHALDPGRVVSEIHVRHAYRTCTADKMKKADYPYLIHSDGNIIQIDCQIISVSPHSVKSNEPAFGVWLIFDSVDNRASDFVRSMRSSVILEEVVISDESEEEEDLSADEDYVDSEWEVVPHNIASYTTIKELGIGAYGQVKLATYKSNKVHEVILKSISKSRILLDSWMRDKDLGTVPMEISILHFLKAHSHPNIVKMITFFEDNENYYLLTEPQKPGIDLFDYIELKPSISEKESKAIFFQIALAVAHLHSFDIIHRDIKDENVILEGNGCARLIDFGSSSLTKNGPFDTFRGTVGFAAPELLRGEKYLGKEQDIWALGILLYTIVYRENPYYNIEEILDAKLRIPFELSKDNVDLICRMLDRNVHDRITIEETLQHHWFDDIRYLDTSHIRIPLSS
What are the official names of this protein?
Serine/threonine-protein kinase ppk6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ILVC_GEOSL
Sequence: MKIYYDKDCNQSVLKGKRVAVIGYGSQGHAHANNLKDSGVDVVVGLKADSSSVAKATGAGLTVLPTADAVKGADVVMILLPDEIQGDVYREEVGPYLKQGAYLAFGHGFNIHFGQITPRPDINVIMAAPKGPGHLVRHEYTRGGGVPCLIAIHHDPSGNSRDVALAYASAIGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYSPEMAYFECLHETKLIVDLIYEGGIANMRYSISNTAEYGDLTRGPRVITDETKKEMKQILWEIQSGQFAKEWMLENKANKPTFNALRRKGMEHPIEDVGARLRSMMSWIGSSKIVDKSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: KATG_ACIBY
Sequence: MSNESKCPFSGHNSKPQVTVGGGTANLHWWPNQLRVDLLNQHSERSNPLGKDFNYRQEFKKLDYYALKADIKNVLTDSQDWWPADWGNYTGLFIRLAWHAAGTYRMGDGRGGAGRGQQRFAPLNSWPDNASLDKARRLLWPVKQKYGQKISWADLFILAGNIALESSGFRTFGFGAGREDVWEPDNDVNWGDEKEWLAHRNSEALAGSNLAATEMGLIYVNPEGPQASGDPRSAAPFIRATFGNMAMDDEEIVALIAGGHTLGKTHGAAPADHVQADPEGAPIEQMGFGWANSYGTGVGKDAITSGLEVIWSQTPTQWSNYFFENLFKYEWVQERSPAGAIQWVAADAEAIIPDPFDPSIKRKPTMLTTDLTLRFDPEFEKISRRFLNDPQAFANAFARAWFKLTHRDMGPKARYLGPEVPTEDLIWQDPLPAASATPSSASIADAKAKIVALGLPAGELVSLAWASASTFRGGDKRGGANGARIALSPQREWEVNKKAVETLTKIEELKASTQLSLADLIVLAGNVGVEQAAQAAGFNITVPFAPGRVDALQSQTDVESFQLLLGLADGFRNWKKQGVNTPAEVLLIDKAQQLTLTAPELTALIGGLRVLGTNWDGSQHGVFTQQVGVLSTDFFTNLLDMSNVWAPVDSTSEVFEGKDRKSGTVKFTATRNDLVFGSNSILRALAEVYAQADGKEKFVQDFVAAWTKVMNLDRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: ICLN_SCHPO
Sequence: MITKIDSLPKDLIRKVENGEKLLPNQEIVYFEEKTVPYKIRSDEESFPLGKLITLLVTSQSFILFDEEQNSGWKIPYETITLHAKQSKDKPYVYVQLEGEAIRPLLDHILKFERSSGTLHEAPSTEDENEFTDDFLELTLYVTDVDSCYQALCTCQSLHPDTFSSDNDVENASMGNPMSLFFDPNHQWVTAENVDTSACDNRFDSPESPVLKWHRTE
What is the function of this protein?
Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:24298023).  Most spliceosomal snRNPs contain a common set of Sm proteins smb1, smd1, smd2, smd3, sme1, smf1 and smg1 that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity).  In the cytosol, the Sm proteins smd1, smd2, sme1, smf1 and smg1 are trapped in an inactive 6S pICln-Sm complex by the chaperone saf5 that controls the assembly of the core snRNP (By similarity).  Dissociation by the SMN complex of saf5 from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
What are the official names of this protein?
Splicing factor saf5.
What is the protein family that this protein belongs to?
Belongs to the pICln (TC 1.A.47) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes to the nucleus predominantly.
Protein: PEPE_ECOUT
Sequence: MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPLGVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HGD_BURMS
Sequence: MERTTIMTLDFSKPGEAGYQSGFANEFATEALPGALPHARNSPQRAPYGLYAEQFSGTAFTAPRGHNRRSWLYRIRPAAVHRPFELVSGERRIVAEFGDSDDVPPTPPNQLRWDPLPMPAQPTDFVDGWVTMAGNGSAAAMSGCAIHLYAANRSMRERFFYSADGELLIVPQEGRLFIMTELGRLDVEPFEIAVIPRGVRFAVALPDGRARGYVCENFGALLRLPDLGPIGSNGLANPRDFLTPHASYEDREGAFELVAKLNGRLWRADIDHSPFDVVAWHGNYAPYKYDLRHFNTIGSISYDHPDPSIFLVLQSQSDTPGVDAIDFVIFPPRWLAAEDTFRPPWFHRNVASEFMGLVHGVYDAKAEGFVPGGASLHNCMSGHGPDADTFEKASSIDTSKPNKVGDTMAFMFETRTLIRPTRFALDTAQLQANYFECWQGLKKHFNPEQR
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: SYC_PARMW
Sequence: MSLRLTNTLTRRTEPFTPLTPGKASIYCCGVTVYDLCHLGHARSYINWDVLRRFLIWRGLEVTFVQNFTDIDDKILKRAAEQNSSMTEVSERNIDAFHQDMDALGILRPDRMPRATQCLDGIRSLIGELEAKGAAYSADGDVYFAVMKHAGYGKLSGRDLSEQQDNAAGRVADAEEARKQHPFDFALWKGAKPGEPSFPSPWGEGRPGWHIECSAMVRAELGDTIDIHLGGADLVFPHHENEIAQSEAATGKELARVWMHNGMVNVGGQKMSKSLGNFTTIRALLESGVSPMTLRLFVLQAHYRKPLDFTAEALEAAATGWKGLNAALGLGERYSDQLGWPSPAALSEDAIGPQTSPDAEALQALEQQFIGSMEDDLNSSGALAVLFDLAKPLRALANRLERGDEPGLPEADIRNLAPRWQLLRELAVVLGLRGETSGQSNMDDESIDATIAARKAAKAAKNYAEADRIRNELTAQGIELIDKPGGITEWIRS
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_BRUA2
Sequence: MTDIIRQLEAEQAAKIEEKRKLPDFQPGDTVRVQVRVTEGTRTRVQAYEGVCIARSGAGLNENFTVRKISYGEGVERVFPVYSPIVEGVEVVRRGKVRRAKLYYLRGLTGKAARIAEKKDNRTKAERAADKLAAAKAEAAKTAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: WECF_ECOBW
Sequence: MTVLIHVLGSDIPHHNRTVLRFFNDALAATSEHAREFMVVGKDDGLSDSCPALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPTLWLALLSGGIKPSQFFWHIWGADLYELSSGLRYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLFFPTRMDPSLNTMANDRQREGKMTILVGNSGDRSNEHIAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQILSEKLEFDAYLALLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDIVREAQRQLASVDKNTIAFFSPNYLQGWQRALAIAAREVA
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
What are the official names of this protein?
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase, 4-alpha-L-fucosyltransferase, TDP-Fuc4NAc:lipid II Fuc4NAc transferase, Fuc4NAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 56 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MCPT1_MERUN
Sequence: MQALLFLLALLWPPEAGAEEIIGGVESKPHSRPYMAHLTITTKQGFTASCGGFLINPQFVMTAAHCKGREITVTLGAHDVSKKESTQQKIKVAKQIAHPSYSFYSNLHDIMLLKLQKKAKVTASVDVISLPSPSDFINPGKVCRAAGWGRTGVTEPTSDKLREVKLRIMTKAACKNYEHYDYNFQVCVGSPSKIRSAYKGDSGGPLVCAGVAHGIVSYGRIDAKPPAVFTRISPYVPWINLVIRGK
What are the official names of this protein?
Mast cell protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
Protein: AGUA_PSEPK
Sequence: MKTLNSTPRADGFHMPAEWAPQTQVWMVWPERPDNWRLGGKPAQAAHVTLAKAIARFEPVTVAVSAGQYENARRQLDQPNIRVVEISNDDAWVRDTGPTFVINDHGEVRGVDWGFNAWGGFDGGLYAPWNRDEELAAKVLEMERCQRYQTEGFVLEGGSIHVDGEGTVITTEECLLNRNRNPHLSREQIEAVLRDHLAVDTVVWLPDGLYNDETDGHVDNFCCYVRPGEVLLAWTDDSNDPNYARCHAAMDVLKNTRDAKGREFIVHKMPIPGPLFATAEECAGVDQVAGSQERDPSVRLAGSYVNFLIVNGGIIAPSFDDPADAEARAILARIFPDHEVVMIPGRELLLGGGNIHCLTQQQPAPVKR
What is the function of this protein?
Mediates the hydrolysis of agmatine into N-carbamoylputrescine in the arginine decarboxylase (ADC) pathway of putrescine biosynthesis, a basic polyamine.
What are the official names of this protein?
Agmatine deiminase, Agmatine iminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the agmatine deiminase family.
Protein: RL18_SALCH
Sequence: MDKKSARIRRATRARRKLKELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: YTFE_SALHS
Sequence: MAYRDQPLGELALSIPRASALFRQYDMDYCCGGKQTLARAAARHDVDIDIIEAQLAQLAEQPIEKDWRAVPLADIIDHIVVRYHDRHREQLPELILQATKVERVHADKPNVPRGLTKYLTALHEELSSHMMKEEQILFPMIKQGMGRQATGPISVMESEHDEAGELVDVIKHVTQNVTPPPEACTTWKAMYNGINEMIDDLMEHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.