PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_FRATO
Sequence: MTPNEFFSIKYHILAKAELKAYIDKLADYLSQQSYLYHTLDKPIISDSDYDKLFRLLQDLVNDNPQFKPINSVLDRVGGEVLAGFETIKHKKKMTSLANVFSLEELRDFYDKIEYDIELECEPKMDGLAISIFYKNGKFDYAVTRGDGIQGEKVSENVKTIRNVPLKLNTSNPPEELEVRGEIILDKQSFLSLNEYMQTHENKTFANPRNAAAGSIRMLDSKVVAKRPLKLYSYGIGYFSKDFVYPETQFELMQLLQSFGFTISDNMFLAKNFSEVEEYHHKMSHQRADLAYDIDGLVFKVNNIKLQDTIGYTARGPKWAIAYKFPAEEVESEVLNVEFQVGRTGAITPVARLKPVAVGGVIVSNATLHNINEIKSKDIRVGDRVIVRRAGDVIPEVVKSLPQYRKSDAQIVEMPTNCPVCDSKIENVNDQAIYRCTGGWHCQAQTTERLKHFVSRKAMDIDKLGAKLIEQLVAANLIKYPADIYKLNFEQLTGLERMAAKSSQNVLDSITKSKEPSLARFIFAIGIKDIGEVSSDALANHFGSLESFRDAKFEELIEINYVGEIIANNIVSFWHDSLNIKIVEEFLAIGIKIQNPVKVEHAYNESFTGKTVVITGSFENYGRTELTQLLKSIGAKVTSSVSKKTDMVICGDNAGSKLTKAQELGVEVILEDNLKDLL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: Y12A_BPT4
Sequence: MKSSLRFLGQELVVEGVIPADNAFNEAVYDEFIKIFGTDKKFGIFPSENFSKPEQTESIFQGVVTGKFESEAPVKIEVYIEDSLVASVAAFISFRK
What are the official names of this protein?
Uncharacterized 10.7 kDa protein in Gp54-alt intergenic region.
Protein: GRPE_UREP2
Sequence: MSKNNENIKHQNNDKVNNQVDKKETKNHNKQEFKYKELYEHELKKNKELQNINTLLKDKNQQLEEQISQLNQDFIKQLETKAKQAQQILEQKVNELEARHEAKVNDAVFKIFKFKMEPLLDAINHFTKIVNQNYDDPKIQAFIEGFKMFSQNMIDGLDNLKITKISPQVNDSLNDEIMEVFEVVENTNKPSMHVVEVISDGFKYNDKVIKFAVVKVAK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDG_BPT4
Sequence: MNYDRIYPCDFVNGPGCRVVLFVTGCLHKCEGCYNRSTWNARNGQLFTMNTVKELASHLSKSYIQGLTLTGGDPLYPQNREEISNLVSWVKARFPEKDIWLWTGYKFEDIKQLEMLKYVDVIIDGKYEKNLPTKKLWRGSDNQRLWSNTDGVWKHD
What is the function of this protein?
Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
What are the official names of this protein?
Anaerobic ribonucleoside-triphosphate reductase-activating protein, Class III anaerobic ribonucleotide reductase small component.
What is the protein family that this protein belongs to?
Belongs to the organic radical-activating enzymes family.
Protein: GHRB_SERP5
Sequence: MKPSIVLYKNIPADLRERLEQHFTVHAFDGLTPDNHDELRQALQQAEGIIGSGGKIDEAFLQQTPKLRAASTISVGYDNFDVDALNAHNVLLMHTPTVLTETVADTIMSLVLATARRVVEVAERVKAGEWQGSIGADWFGVDVHHKTIGILGMGRIGLALAQRAHFGFGMPVLYNARRTHEEAEQRFNARRCDLDTLLAESDFICITLPLTDETFHMISRDQLAKMKKSGILINAGRGPVVDEAALIEALQNGTIHAAGLDVFEKEPLPVSSPLLTLPNVVALPHIGSATHETRYGMAECAVDNLIAALTGTVKENCVNPQLLKK
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_STRS2
Sequence: MGKYFGTDGVRGEANVELTPELAFKLGRFGGYVLSQHETDVPRVFVARDTRISGQMLEAALIAGLLSVGIHVYKLGVLATPGVAHLVKTEKASAGVMISASHNPAQDNGIKFFAGDGFKLDDALEAEIEALLDAEEDTLPRPSAQGLGDVVEYPEGLRKYQQFLVSTGTDLDGMKVALDTANGAAATSARQIFVDLGADLTVMAEKPDGLNINEGVGSTHPEKLQELVKETGSQIGLAFDGDSDRLIAVDENGVLVDGDRIMYIVGKYLADRGLLAKNTIVTTVMSNLGFHKALDREGIEKAVTAVGDRYVVEEMRKEGYNVGGEQSGHVILMDYNTTGDGQLTAVQLTKIMKETGKKLSELAAEVTIYPQKLVNIRVENSMKDKAMEVPAIAAIIEKMEAEMAGNGRILVRPSGTEPLLRVMAEAPTDAEVDYYVDTIADVVRAEIGS
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: GLPK_XYLFA
Sequence: MKKKYILAIDQGTTSSRAILFDQKGHIAGMAQREFTQIFPQPGWVEHNPRDIMTSVYTTITELLNNTQIDVRAIAGIGITNQRETTVIWDRQTGQPIYNAIVWQSRQTKDICDQLTTAGYQDLVHAKTGLLIDAYFSGTKVKWILDHVENAHTQATRGELAFGTIDTWIIWNLTGGQVHVTDYSNASRTLLYDIHALRWDPDLLTMLDIPAAILPDVRSSSDIYGLTQTPYFHGEQIPIAGIAGDQQAALFGQACFEPGMAKNTYGTGCFMLMHTGKKAVESKNGLLTTIAWGLNGEIEYALEGSIFVAGSVVQWLRDGLRMFGKASDSQAYADRVSDNGGVYVVPAFVGLGAPYWRSDVRGAVFGLTRSTTKEHFIRAALESMAYQTRDVLSAMQADAGMELKELRTDGAAITNDFMAQFQSDILAVPVLRSEIAETTALGAAYLAGLATGFWSSREEITQHWAINLCFKPQMDKQQREHLYAGWKQAVAATLGFRVA
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: SSRP_EHRRW
Sequence: MDIIIENRKVRFNYFIIQEFDAGIVLIGSEVKSLRQRKVSIAESYVTERNMELWLCNLHISEYTQANTKNHNPTRPRKLLLKKKQIYKISGNMKNDGFTVVPLFLYFNDKGIAKAKIVIVKGKKLHDKRETIKARDWNREKSRILRGG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: HV338_HUMAN
Sequence: MQFVLSWVFLVGILKGVQCEVQLVESGGGLVQPRGSLRLSCAASGFTVSSNEMSWIRQAPGKGLEWVSSISGGSTYYADSRKGRFTISRDNSKNTLYLQMNNLRAEGTAVYYCARY
What is the function of this protein?
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains (PubMed:24600447).  Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Probable non-functional immunoglobulin heavy variable 3-38.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: TSR1_SCHPO
Sequence: MAHHHRSTFKAKKPFKSKHASKSSLKEKYKNEVEPHRSGPKNIVHTSTKADRRNTAKQIQLNKRTEVAMNNRIFGGKNGAPKVITIVPLCNNVDSWNVLTNLLRSIDPEASLPKFDKDSISYSTTIDRFKQNLLFLLPKREFYSLIDACKVSDYVIFVLSAVQEVDEFGELIVRTTQGQGISSVLSMVHDLSEVDSLKTRNEVKKSLQSFMNFFFSDQERVFAADVSQDALNVMRALCTSHPRGIHWRDSRSYLLSQEISYSNGNLLVRGIVRGKGLDPNRLIHIQGFGDFAINRIYEAPQGIQNSRGISMDEDTNLTGGLVELCSPTQEQDSLESLGPIIDDMDTDMDSEVGKEASRGVRLDDFYYFDDEEEPVAVAKRVPKGTSTYQATWIPDEDEESDQYSDVEDTEVIIEDQDNQEISNHVAEEKIDSDEEETIDDAKSEMFVDLSEEEEVRQYEEYRKKQKELQEELEFPDEVELQPNELARERFKKYRGLRSLYTSQWDADEYDPNEPREWRQLFKFENYRNLKNKFLKQPFIGEAKPGKAVYVELRNVPIEIFEYYNKPWNLLVLYSLLQYENKLTVSQFTAMQHSEYEEPIESKEELLLQIGPRRFMVRPLYSDPTASGASNNLQKYHRYLPPKQAVIASVISPIVFGNVPIIMFKKSSDNSLRLAATGSYVNCDTNSVIAKRAVLTGHPFKVHKKLVTIRYMFFNPEDVIWFKPIQLFTKQGRTGYIKEPLGTHGYFKATFNGKITVQDTVAMSLYKRMYPLPCELFKVTDIDS
What is the function of this protein?
Required for 40S ribosomal subunit synthesis.  Required for normal export of the pre-40S particles from the nucleus to the cytoplasm (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein tsr1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: MURB_AGRRK
Sequence: MKQVNGEKLLASLGDSVKDIRGRLTPDAPMDRVTWFRAGGLAELMFQPHDTDDLIDFLKILPDDVPLTVVGVGSNILVRDGGIPGVVLRLSAKGFGSVELAGENRILAGAICPDKHVAAMAMDNGIGGFHFYYGIPGGIGGAARMNAGANGAETCERVIEVHAVDRKGVKHVLTNDQMGYTYRHSAAADDLIFTHVLFEGYPEDRTKIRAEMDAVRAHRETVQPIREKTGGSTFKNPDGLSAWKLIDEAGCRGLVIGGAQMSSLHCNFMINMEQATGYDLEYLGEQVRREVFEKSGVKLEWEIKRLGGFMPGREVRPFQGVTTE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSAC_RHOJR
Sequence: MSIRSLAYMRIEATDMSAWREYGLKVLGMVEGKGSDPDALYLRMDDFPARLVIFPGEHDRLSVSGWETANAAELQEVRDNLSAAGVAFKEGTAEQLQDRRVDELITFEDPSGNTLEAFHGAALEHRRVVSPYGHKFVTGEQGLGHVVLSTTDDEASLRFYRDVLGFRLRDSMRLPPQLVGRPADGKPAWLRFFGCNPRHHSLAFLPMPTPSGIVHLMIEVENSDDVGLCLDRALRKKVKMSATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVEDESWIARESTAVSLWGHDFSVGMQP
What is the function of this protein?
Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).  Also involved in biphenyl and polychlorinated biphenyls (PCBs) degradation.
What are the official names of this protein?
Iron-dependent extradiol dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the extradiol ring-cleavage dioxygenase family.
Protein: CARA_LISIN
Sequence: MTKRILMLEDGNYFIGDAIGSEKETIGEVVFNTGMTGYQETITDPSYYGQIITFTYPLVGNYGVNRDDFESINPAVKGVVVREAAEYPSNWRNQITLNEFLKEKGIPGIAGIDTRKLTKLIRKEGTLKGILSAATADKEELLHHLRSVRLPVDQVHEVSSAKAFASPGDGKRVVLVDYGVKSSILRELNKRNCYVTVVPYNTTAEEILAMHPDGVMLSNGPGDPKDVPEALEMIRGIQGKLPLFGICLGHQLFALANGADTFKLKFGHRGANHPVKELATGRVDFTAQNHGYAVEKESLIGTDLKVTHIELNDETVEGLAHKEYQAYTVQYHPEANPGPSDVNYLFDEFMEMMNVKEEGELHA
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: TRPB1_COREF
Sequence: MTDNKNLGGSTLLPAYFGEFGGQFVAESLLPALDQLEKAFVDATNHPEFRQELAAYLRDYLGRPTPLTECSNLPLPGQGRGYARIFLKREDLVHGGAHKTNQVIGQALLAKRMGKTRIIAETGAGQHGTATALACSLLGLECVVYMGAKDVARQQPNVYRMQLHGAKVIPVESGSGTLKDAVNEALRDWTATFHESHYLLGTAAGPHPFPTIVREFHKVISEEAKAQMLERTGKMPDVVVACVGGGSNAIGMFADFIDEEGVELVGAEPAGEGLDSGKHGATITNGQIGILHGTRSFLMRSSDGQVEESYSISAGLDYPGVGPQHAHLHSTGRATYVGITDAEALIAFQYLARYEGIIAALESSHALAYALKRAKLAEEEGKQITILVSLSGRGDKDVDHIRRTLEEKPELILKEEER
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain 1.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: MBA1_YEAST
Sequence: MSVLRSTCLFFPPRSLLISFNKRRLFSTSRLILNKESETTKKKDKSKQQDFNPRHLGVAAEIFIPSAYKNLPNVFAHPLIVANALIRRLYTFGLNSVQVALFRFQSGIKPSFLLWKNKAIETYINVNTSFAHKNLSDIKGLVSLWVQEALEARSRQLPGNATLDWQLIKFNAVPKLVSVQPIMIPGMPLEHLQLVYKFDTKQRLIKVNQQTKKTETLDRDVVDYIAFLCDATTNDMILMGSLFESKPNDKLPKSYEDDAKVAIHRMKVNGDIYRLPPS
What is the function of this protein?
Mitochondrial inner membrane-associated mitoribosome receptor that spatially aligns the mitoribosome exit tunnel with the membrane insertion machinery and allows cotranslational protein membrane insertion.
What are the official names of this protein?
Inner membrane mitoribosome receptor MBA1, mitochondrial, Multi-copy bypass of AFG3 protein.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Localizes near the mitoribosome exit tunnel.
Protein: RS8_XANCP
Sequence: MSMTDPIADLLVRIKNAAAVGKQTVKLPSSKIKVAIAQVLKDEGYITDLRVTATENNKSELEIVLKYFEGRPVIETLKRFSRSGLRQYRGKTELPKVLGGLGIAIISTSKGIMTDAQAREAGVGGEVLCFVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: DAS2_YEAST
Sequence: MDRKAVEEKRIVISIGGGHATGVGAIALDLQNTFKSLYNSINIRVINLDNMIEGNIKSYNNNDYDFDNILNLVYEKHAVTSQNDMIQHDYEDPIDLIIVCGCYALYDKRINEISQLKVFLDSDADKRLISLIKKKNVGSNEQLAQLITEYMDHLRPEMQQYIEPTRTFADLIIPSTNENLGRAVLVDGIVKAIEDTKSQIEGNNTNNKIRPRLWDFEAETMDLEKDRYYDLS
What is the function of this protein?
Putative uridine kinase identified in a screen for mutants with increased levels of rDNA transcription.
What are the official names of this protein?
Putative uridine kinase DAS2, DST1-delta 6-azauracil sensitivity protein 2, Regulator of rDNA transcription 3.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RMI1_DANRE
Sequence: MSVGEVQVIQAWLRSEWHIQVPPAWLDACVNWIKEEADRASIPQSQLNQRVLEQWLLTDLRDLAHPVLPERISEAQKTVLSNRCCVQMDSLLDVSQPAYNQLQRIRGTDCSNDQVSAVTQETQRPWEAKPTRMLMLQLTDGVQNLEGMEYRPIPALNANLPPGTKLQLVGPIAVRLGVLLLKAENIKVLGGEVEQLLEIHSQSRVLCGTLGLPEETHPQQEPDGLVASVADSGYSSLASEASLRHPQSQPLPQISRQDDWDMDEIPDDDFRSIPDHFDDLPQNNNPLEDVPEDFDDIPLDELDNVMCPIDVEVSAGTLEDPERNKHDSSLLNGSKPEEVSFPSRSRLGNTYQSRTLNKVPNTSLASCSTSTLDSSACKETPMYLCSLQAGCWPPKSPQVFRLQAFIVTLVGNLRISGGVWKLGATISDGSGYLDVDLSDNMLSELIGFSAAETRVLRKDLARRGEVDSGIQHCQRELVDMCCMMSVQVDLTGRGVVLSASPISDRECSEMQKRVKEARR
What is the function of this protein?
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.  Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution.  Required for BLM phosphorylation during mitosis.  Within the BLM complex, required for BLM and TOP3A stability (By similarity).
What are the official names of this protein?
RecQ-mediated genome instability protein 1.
What is the protein family that this protein belongs to?
Belongs to the RMI1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YIZA_BACSU
Sequence: MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFHIIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELVSVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY
What are the official names of this protein?
Uncharacterized protein YizA.
What is the protein family that this protein belongs to?
Belongs to the DinB family.
Protein: M2_I72A2
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: YCF4_CUSRE
Sequence: MSWRSEHIWIDLITGSRKISNLCWAFTLFLGSLGFVLVGTYSYLGRNLISFFPLQQIIFFPQGIVMSFYGIAGLFISSYLWCTISWNVGSGYDLFNRKEGIVCIFRWGFPGINRRIFLRFLLKDIRSVRIEVEEGIYAGRVLYMDIRGHRAIPLTRTDENLTPGELEKKAAELAYFLRVPIEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid thylakoid membrane; Multi- pass membrane protein.
Protein: TPM_PERVI
Sequence: MDAIKKKMVAMKMEKKNALDRAEQLEQKLRETEEAKAKIEDDYNSLVKKNIQTENDYDNCNTQLQDVQAKYERAEKQIQEHEQEIQSLTRKISLLEEGIMKAEERFTTASGKLEEASKAADESERNRKVLENLNSGNDERIDQLEKQLTEAKWIAEEADKKYEEAARKLAITEVDLERAEARLEAAEAKVIDLEEQLTVVGANIKTLQVQNDQASQREDSYEETIRDLTNRLKDAENRATEAERTVSKLQKEVDRLEDELLTEKEKYKAISDELDATFAELAGY
What is the function of this protein?
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
What are the official names of this protein?
Tropomyosin.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: QUEA_ACTP2
Sequence: MLVSDFHFDLPDELIARYPTEERTASRLLHLNGETGHFEDKQFFDLLDQINEGDLLIFNNTRVIPARLYGRKASGGKLEILVERVLDEHRCLAHVRASKAPKEGAELVLGEDKLGEGNGFKAIMTARHDALFELHFNEEQPLFDLLQQAGHMPLPPYIDRPDEDADQERYQTVYSKVLGAVAAPTAGLHFDNPTLEKLKAKGVNIAFVTLHVGAGTFQPVRVDNILDHKMHAEYAEVSQAVVDQILATKATGKRVIAVGTTSVRSIESAAQAAEKEGKLITPFFSDTSIFLYPGKTFRIVDALVTNFHLPESTLIMLVSAFAGYRNTMKAYQHAVEAKYRFFSYGDAMFINKNPNALNDLP
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLO_STRE4
Sequence: MDKLIKTISASGAFRAYVLDCTETVRYAQERHHTLSSSTVALGRTLIANQILAANQKGDSKVTVKVIGDSSFGHIISVADTKGHVKGYIQNPGVDIKKTATGEVLVGPFMGQGHFVTITDYGTGNPYTSTTPLITGEIGEDLAYYLTESEQTPSAVGLNVLLDQEDKVKVAGGFMLQVLPGASVEEISHYEKRIQEMPAISTLLASENHIDALLAAIYGEEPYKRLAEEQLSFQCDCSRERFASALMSLPKADLLTMLNEDKGAEIVCQFCGTKYQFDQTDLEVLINDKA
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYAM1_MOUSE
Sequence: MVFPWRCEGTYWGSRNILKLWVWTLLCCDFLIHHGTHCWTYHYSEKPMNWENARKFCKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMWTWVGTNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALCYTASCQPGSCNGRGECVETINNHTCICDAGYYGPQCQYVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQETNRSFSKIKEGDYNPLFIPVAVMVTAFSGLAFLIWLARRLKKGKKSQERMDDPY
What is the function of this protein?
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells.  Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes (PubMed:1693096).  Promotes initial tethering and rolling of leukocytes in endothelia (By similarity).
What are the official names of this protein?
L-selectin, CD62 antigen-like family member L, Leukocyte adhesion molecule 1, LAM-1, Leukocyte-endothelial cell adhesion molecule 1, LECAM1, Lymph node homing receptor, Lymphocyte antigen 22, Ly-22, Lymphocyte surface MEL-14 antigen.
What is the protein family that this protein belongs to?
Belongs to the selectin/LECAM family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PSRP_PARXL
Sequence: MPPTVFIVSDGTGITAETFAHSILSQFDQKFRLVRVPFVDSTEKAYATLEKINEAILQDGRRPIVFTTLVDSASNQIVKGSNALVLDMFQTFVEPLEQELELKSSHAMGRGHQNADTEEYKNRIEAINFSLAHDDGQSNRNLADADVILVGVSRSGKTPTSLYLAMQYGVKAANYPLIPEDFERGKLPTPLLAHRQKMFGLSIDPQRLSEIRNERRPGSKYAAPENCRYEINEAEAMMRREGIKWLSSTHKSIEEIATTILQEIKLERAAY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: CMOA_DESAH
Sequence: MKKDTLFATRKEPVPAFDFNESVASVFSDMLERSVPMYRESITRQAELALDFYRSKTLIYDLGCSHGNFGMLAGKRFGDRPFSMVGVDSSPPMIEKYKQRLEQESFRDNIVLVCDRVENLCLGNASVVVVNLTLQFLSLDRRDTLISDIYTALVPGGILLLTEKVLAWDSSIAAVHLDYYSRFKRENGYSELEISQKREALENVLVPETLEVHQQRLARAGFDRMDVWLKWFNFASMIAVKPERPGK
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.