Protein: MSPS_DROME
Sequence: MAEDTEYKKLPVEERCVHKLWKARVDGYEEAAKIFRELDDEKSPEWSKFAGLIKKMVVDSNALAQEKGLEAALIFVENSGLAGRTVGDVMTGIVQKCIAAPKTKTKELSVQVALMYVEIEKQEAVVEELVKGMEAKNPKIVSACVAATTLALREFGHKVIGVKPLIKKLAPLMSDRDKTVRDEGKQLAVEIYRWIGAAMKAQISTLPQVTLKELEDEFDKLKGERVEPSRYLKSQQEKQAKIADAAATEDAYNEDDGEAGVEEIDPMDLLDPVDILSKMPKDFYDKLEEKKWTLRKESLEVLEKLLTDHPKLENGEYGALVSALKKVITKDSNVVLVAMAGKCLALLAKGLAKRFSNYASACVPSLLEKFKEKKPNVVTALREAIDAIYASTSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQPTALNKKLLKLLTTSLVKTLNEPDPTVRDSSAEALGTLIKLMGDKAVTPLLADVDPLKMAKIKECQEKAEIKIKVAGPKKETRPASAPTAKAAAPAKTVAGSVDPKPVTRPATTGARKVLKKPATVSGGGATSAPTAALKAGGKPLATEREITPEELQEKSEEILPAEILNGLVDSNWKNRLAAVEQLLGEISGFDAKQAGISQILIRTISGRKPGLKEMNFQVLKFKLDIIRSVAENYPLTTTTVDLVINEIIEKLADAKNGAAAADVLSAFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGFQLQPKTLIEDVRKGVQSTNPTVRASAIQMVGTMSMYMGKALMMFFDSEKPALKSQIQVEFDKNVGEKPPKPVRGVQRSSGGTAGNSPDNEDDDGGAAGEEEPINMADLLPRVDIAPQITEALLKEMSDKDWKTRNEGLTKLQAIISEARLIKPSIGDLAPALAHRLVDSNAKIAQTTLAICEQLATAMGAGCRNHVRNLFPGFLHALGDNKSFVRAAALNCINSFGEKGGYKEFFESEMIADALKGGSPALKTELWAWLADKLPGLPPKSVSKEDIHSMVPHLYAHICDRNADVRKNANEAVLGIMIHLGFDAMNRALDKQKPASKKDILAALEKARPNLPVKPLPKGKHQAPIPEEPKLKTVRGGGAGGAPGIQKSATARVAGGQDKQVPARKKDEDIDTSPLLCANSAKNQRLLDEQKMKVLKWTFVTPREEFTELLRDQMMTANVNKALIANMFHDDFRYHLKVIEQLSEDLAGNSKALVCNLDLILKWLTLRFYDTNPSVLIKGLEYLVQVFQVLIDEEYILAENEGSSFVPHLLLKIGDPKDAVRNGVRRVLRQVILVFPFVKVFGYVMEGLKSKNARQRTECLDELTFLIESYGMNICPQSAVREIARQISDRDNSVRNAALNCIVQVFFLSGEKTYKMIGHLNEKDLSMLDERIKRAKKTKKPTPPPSVDVPAPQRHDSIEIEDAEVGNGCDELPPPDEDGTFDQAPSSQLLLLQQQLQQLQQQAQQQKPSGPFGLDSQVISEIEKDWVRVDQMEQKPLLNVDISSLDEPIKVRPTRAGIHYPQEKFDRLISRQHYMQQTLTTSPSSTAGMTSGVSPYRSPMRLQHQQPQQQLENNIPNLADVLPKHDPQLVKVIKGVSSTDTLKARAAINELAAIIEAPEKQAVLRDYEEIFIQNVLAQFKNLSQIPSAQSVVVYQPLLSILYTFFHANILGKTLSVACIKNLMSALLNLMADPKLAVGDDSQYNKVINGICLKVLDKVDFTNLNCALIRLLRETCPEAKLPKFTDLLMKCIWRNVKMLPERSNELNYDAVILEVHEFMLALPSTWWQNRPSDTPMRTIKTILHNMAKVKGNAILQHLNQIPTHSELHTYLIRILKNFQKDGSASGIGASPQRAKEIASKRISHQTHDTVSQIFKLISDRDTKQQGLQKLYDFKQQNPDIDLSTFLQGSSAPFHKYIEEGLAEIERNQNAGSTQDNRTDVNYQNNGPDPDFWMDRLQYHMTGGAAKLASARSADDGSHMLDNKVVDENLCLNGMNAQKASLIKREKRDMSPNRLQHLQAKLAQIKKENHAQ
What is the function of this protein?
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization.  Promotes cytoplasmic microtubule nucleation and elongation.  May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage.  Involved in mitotic spindle elongation.  Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts.  Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd.  Involved in oocyte microtubule cytoskeleton organization and bicoid mRNA localization.  Seems to be involved in elongation of kinetochore-derived microtubule fibers.
What are the official names of this protein?
Protein mini spindles.
What is the protein family that this protein belongs to?
Belongs to the TOG/XMAP215 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the plus ends of growing microtubules in the cell interior in a Eb1-dependent manner. Localizes to the lattice of growing and shrinking microtubule in a discontinuous pattern in the peripheral regions of interphase cells. Localized at acentrosomal poles of female meiotic spindle. In embryos, associates with centrosomes in prophase and metaphase, then associates with spindle microtubules.