PharMolix/UniProtQA huggingface dataset:
Protein: RL5_TERTT
Sequence: MARLKEKYLNEIAPKLKEELGVANVMEIPRITKITLNMGVGEAIGDKKVLENAVADLEKIAGQKPVITKARKSIAGFKVREGWPVGCKVTLRRERMYEFLDRLVSIAIPRVRDFRGISPKQFDGRGNFSMGVNEQIIFPEIEYDKVDKLRGLDICISTTARTNEEGRALLKAFSFPFKG
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: PTH_STAAW
Sequence: MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_CHLL2
Sequence: MYRAEESMMPLENRFRTDYCGLLGVGSENRSVRLGGWVHRKRDHGGLIFIDLRDHTGVCQLVIQPEQQALFNAVEHLHAESVICIEGTVVLRSSETVNTRLASGEIEVVVSSVIIESDAQPLPFPVADEVPTSEELRLKYRFIDLRREKIHENIIFRSRLTAMVRRYLEEREFIEIQTPILTSSSPEGARDFLVPSRLHPGKFYALPQAPQQFKQLLMVSGFPRYFQIAPCFRDEDARADRSPGEFYQIDMEMAFIEQNDLFEILEGMFKHLTENMSQKRITQFPFPRISYREVMNRFGSDKPDLRIPLEIQDVTSLFVNSSFKVFASNTKEGTCVKALVLKGRGGESRMFYDKAEKRARELGSAGLAYIQFREEGPKGPIVKFLGEAEMEVLKEQLGLETGDVVFFGAGKWESTCKIMGGMRIYFADLFDLDKDELSFCWIVDFPMYEYNEEAKKIDFSHNPFSMPQGEMEALETMQPLDILAYQYDIVCNGIELSSGAIRNHRPDIMYRAFEIAGYTKEEVDSRFGHMIDAFKLGAPPHGGIAPGLDRMVMILRDEQNIREVIAFPMNQQAQDLMMSAPSEVMAQQLKELHLKIDLPPVKEAK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_ECOSM
Sequence: MYQDKILVRQLGLQPYEPISLAMHEFTDTRDESTLDEIWLVEHYPVFTQGQAGKAEHILMPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVNTLAELGIEAHPRADAPGVYVGEKKICSLGLRIRRGCSFHGLALNVNMDLSPFLRINPCGYAGMEMAKISQWKPEATTNNIAPRLLENILALLNNPDFEYITA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_CORGB
Sequence: MIASLRGTVINIGLSSAVIECNGVGYEVVTTPNTLSQLVRGEEALVLTTMVVREDAMKLYGFIDNESREMFSVLQTVSGLGPRLALACESVLSPLEISQAITNADAKALQRVPGVGKRMADRLIVELKGKVAAFAAGVVDEAGEQISLPNANIASEVVVEQVSQALVGLGFSEKQSDDAVSFVLAADPSLDTSGALRAALAKLSGK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: MUTS_ALKOO
Sequence: MRKLTPMMQQYMEIKNQYKDALMFFRLGDFYELFFDDAETASRELEITLTARDCGLESKAPMCGVPYHAANGYIDKLVSKGYKVAICEQVEDPSVAKGIVKRDVVRVITPGTLIDTNLLEDKKNNYLVSLYMSSLGCGFSYVDISTGELLSTEIVGTSIEQNLIDEISKIEPNELIYFVEEEDKIGTNFIEGIRKKLNIHISKYDPWTFEESYAMNQIKNQFNILTVESLGFSLNHLGINATGALIHYLKSTQKRTLSHINKINIYTFTEKMVLDISTRRNLELTETIRGKNKKGSLLWILDKTQTAMGGRMIRKWIEEPLLNIQNINRRLEAVATLKNDILLRCELKESLKQIYDLERLSGKIAFGSATPRDLVALKKSVAFLPDIKKLFENENSGLLKELLNNIDTLEDIQALIESSILDEPSISLKDGGIIKEGYNDELDELYVAAREGKHWIAKLEQAEKDRTGIKSLKVGYNKIFGYYIEITKSNLHLAPENYIRKQTLANCERYITPELKELEDKILGAEEKSIAIEYEQFIEIRNMLLHEIERIQRTARAVAELDVLYSFAEAASENNYVKPTVNSSETIDIKEGRHPVVEKVLENNMFISNDTYINTEDEQLLMITGPNMAGKSTYMRQVALIILMAQIGSFVPATSATIGITDRIFTRVGANDDLSQGQSTFMVEMSEMATIVNLATKKSLLIVDEIGRGTSTFDGLSIAWSTAEYICQSLGSRTLFSTHYHELTKLSETYRGIKNYKVLVKEDKEDVIFLHKVVKGNADRSYGIQVAKLAGLPAAIITRASHILSDLERESIQKEQYIIESTAENTLTASTDVANEKQLKLDDFIESEIVKDLKKINLLETTPMDALNILYQLQKKVAEI
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: RR4_POPAL
Sequence: MSRYRGPRFKKIRRLGALPGLTSKRPRAGSDLRNQSRAGKKSQYRIRLEEKQKLRFHYGLTERQLLKYVRIAAKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPRARQLVNHRHILVNGRIVDIPSYRCKPRDIITAKDEQKSRVMIQNSLDSFPQEELPKHLTLHPFQYKGLVNHIIDSKWIGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RRAAH_NOCFA
Sequence: MPEPANTESTVVATADLADEIGPEIRSCDTQFIQFGGRAAFSGRITTIRCFQDNLLVKQTLGEPGEGKVLVVDGGASVHTALVGDIIAGRGVDNGWAGVIVNGAVRDSAILRTLDIGIKALGTNPRKSTQTGSGERDVPVEFGGVTFVPGEMLYSDHDGIVVRAE
What is the function of this protein?
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.  Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
What are the official names of this protein?
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase, HMG aldolase, Oxaloacetate decarboxylase, OAA decarboxylase, Regulator of ribonuclease activity homolog, RraA-like protein.
What is the protein family that this protein belongs to?
Belongs to the class II aldolase/RraA-like family.
Protein: WNT1_HUMAN
Sequence: MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors (Probable).  Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646).  In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity).  Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity).  Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646).
What are the official names of this protein?
Proto-oncogene Wnt-1, Proto-oncogene Int-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: CHDC_GEOS3
Sequence: MSEAAQTLDGWYCLHDFRTIDWSAWKTLPNEEREAAISEFLALVDQWETTESEKQGSHAVYTIVGQKADILFMILRPTLDELHEIETALNKTKLADYLLPAYSYVSVVELSNYLASGSEDPYQIPEVRRRLYPILPKTNYICFYPMDKRRQGNDNWYMLSMEQRRELMRAHGMTGRKYAGKVTQIITGSVGLDDFEWGVTLFSDDALQFKKLVYEMRFDEVSARFGEFGSFFVGTRLPMENVSSFFHV
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis (PubMed:27936663).  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway (PubMed:27936663).  The reaction occurs in a stepwise manner with a three-propionate harderoheme intermediate (PubMed:27936663).
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: DART_THES0
Sequence: MKRTYPEPTPIYHITHIDNLKGILRMGKLLAHNQSPPKQRSIAYAHIQERRNRAKVPQPPGGVLHDYVPFYFCPRSPMLYAIYSGATEYQGGQEPILHLVSSAQAVHKAGLPFVFTDRHGVLSHARFFRQLEELAQLDWEAIQASYWADPPELREKKQAEFLVYKAFPWALIEEIAVYSQRVGEEVLKILKQFPEARRPRVCIRKDWYY
What is the function of this protein?
Toxic component of a hybrid type II/IV toxin-antitoxin (TA) system.  ADP-ribosylates ssDNA on the second thymidine of the consensus sequence 5'-TNTC-3'; the protein does not auto-modify.  Arg-51 is highly flexible, allowing it to assume multiple positions in the crystal structures (PubMed:34408320).  Its toxic effect is neutralized by cognate antitoxin DarG (By similarity).
What are the official names of this protein?
DNA ADP-ribosyl transferase, DarT, Toxin DarT.
What is the protein family that this protein belongs to?
Belongs to the DarT ADP-ribosyltransferase family.
Protein: Y396_HELPY
Sequence: MRDFLKLLKKHDELKIIDTPLEVDLEIAHLAYIEAKKPNGGKALLFTQPIRKEHDQIKTFGMPVLMNAFGSFKRLDLLLKTPIESLQQRMQAFLHFNAPKNFTEGLKVLKDLWDLRHIFPKKTTRPKDLIIKQDKEVNLLDLPVLKTWEKDGGAFITMGQVYTQSLDHQKKNLGMYRLQVYDKNHLGLHWQIHKDSQLFFHEYAKAKVKMPVSIAIGGDLLYTWCATAPLPYGIYELMLYGFMRGKKARVMPCLSNSLSVPSDCDIVIEGFVDCEKLELEGPFGDHTGYYTPIEPYPVLEVKTISYKKDSIYLATVVGKPPLEDKYMGYLTERLFLPLLQMNAPNLIEYYMPENGVFHNLILAKIHTRYNAHAKQVMHAFWGVGQMSFVKHAIFVNEDAPNLRDTNAIIEYILENFSKENALISQGVCDALDHASPEYAMGGKLGIDATSKSNTPYPTLLNDSALLALLQDKMQNIVLLKQYYPHTRNPICVISVEKKDKSVIELAKNLLGFEEHLRIVIFVEHASNDLNNPYMLLWRIVNNIDARRDILTSKHCFFIDATNKGVMDKHFREWPTETNCSMEVIENLKKKGLLKDFETLNQKFHLTHSFSTHKEDL
What are the official names of this protein?
Uncharacterized protein HP_0396.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
Protein: PSBI_FAGEA
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: NA21_CRYAD
Sequence: MAYLKIVLVALMLVLAVSAMRRPDQQDQDISVAKRVACKCDDDGPDVRSATFTGTVDLGSCNSGWEKCASYYTVIADCCRKPRG
What is the function of this protein?
Binds specifically to the voltage-gated sodium channel (Nav) and delays its inactivation.
What are the official names of this protein?
Delta-thalatoxin-Cad1a, Delta-TATX-Cad1a, Ca I, Delta-thalatoxin-Ca1a, Delta-TLTX-Ca1a.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type II subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: SPAO_SALTY
Sequence: MSLRVRQIDRREWLLAQTATECQRHGREATLEYPTRQGMWVRLSDAEKRWSAWIKPGDWLEHVSPALAGAAVSAGAEHLVVPWLAATERPFELPVPHLSCRRLCVENPVPGSALPEGKLLHIMSDRGGLWFEHLPELPAVGGGRPKMLRWPLRFVIGSSDTQRSLLGRIGIGDVLLIRTSRAEVYCYAKKLGHFNRVEGGIIVETLDIQHIEEENNTTETAETLPGLNQLPVKLEFVLYRKNVTLAELEAMGQQQLLSLPTNAELNVEIMANGVLLGNGELVQMNDTLGVEIHEWLSESGNGE
What is the function of this protein?
Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
What are the official names of this protein?
Surface presentation of antigens protein SpaO.
What is the protein family that this protein belongs to?
Belongs to the FliN/MopA/SpaO family.
Protein: TRPS1_MOUSE
Sequence: MVRKKHPPLRNVASEGEGQTLEPTATESKVSGKNKELSADQMSENTDQSDVAELNSKEEHSTHGQEPSSSGKKDLQISGLSEKAGFNYESPSKGGSLVSFPHDEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEEHKMSPKATEETGPVQSGQANCQGLSPVSVASKNPQVPSDGGVRLSKPKGDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHSKDFQKVNRSVLSGVLQDISSSRPALLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPNKIKVSLPSSEGVKPSEKNSNKSIPALRASDSGDVGKWQDKMTVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLPRGSVINQNDLAKSVEGEPLTKPEKGLSGAKKKDFPSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGVAGSSRVKHQCHQCSFSTPDVDVLLFHYETVHESQASDVKQEANHLLGSDGQQAVRDSKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQEITTANGEEGGHAIPTIKEEPKIDLKVYSLLNPDSKMGETVPESIVKREKLDDKEGLKDKIWTESSTDDLRGVAWRGADILRGSPSYTQASLGLLTPVSSSQEQTKTLRDSPNVEAAHLARPMYGLAVDTKGFLQGAPAGSEKSASLTQQYPASGESKTKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSGEEQVNGSPLERRSEDHLSESHPREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQALDIHKRMQPLHIQIKSPQESTGDPGNSSSVSDGKGSSERGSPIEKYMRPAKHPNYSPPGSPIEKYQYPLFGVPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPTVKNEDPLNVVKTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHIQRGLHRNNAQAEKNGKPKE
What is the function of this protein?
Transcriptional repressor.  Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development.  Regulates chondrocyte proliferation and differentiation.  Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
What are the official names of this protein?
Zinc finger transcription factor Trps1.
What are the subcellular locations of this protein?
Nucleus.
Protein: CO3_RAT
Sequence: MGPTSGSQLLVLLLLLASSLLALGSPMYSIITPNVLRLESEETFILEAHDAQGDVPVTVTVQDFLKKQVLTSEKTVLTGATGHLNRVFIKIPASKEFNADKGHKYVTVVANFGATVVEKAVLVSFQSGYLFIQTDKTIYTPGSTVFYRIFTVDNNLLPVGKTVVIVIETPDGVPIKRDILSSHNQYGILPLSWNIPELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTEKFYYIHGPKGLEVSITARFLYGKNVDGTAFVIFGVQDEDKKISLALSLTRVLIEDGSGEAVLSRKVLMDGVRPSSPEALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKPAMPFDLMVFVTNPDGSPARRVPVVTQGSDAQALTQDDGVAKLSVNTPNNRQPLTITVSTKKEGIPDARQATRTMQAQPYSTMHNSNNYLHLSVSRVELKPGDNLNVNFHLRTDAGQEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLPITPEFIPSFRLVAYYTLIGANGQREVVADSVWVDVKDSCVGTLVVKGDPRDNRQPAPGHQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKNYAGVFMDAGLTFKTNQGLQTDQREDPECAKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMPYSCQRRARLITQGESCLKAFMDCCNYITKLREQHRRDHVLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAVSLSDKKGICVADPYEITVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYREQEKLKVRVELLHNPAFCSMATAKKRYYQTIEIPPKSSVAVPYVIVPLKIGLQEVEVKAAVFNHFISDGVKKILKVVPEGMRVNKTVAVRTLDPEHLNQGGVQREDVNAADLSDQVPDTDSETRILLQGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDQTEQWEKFGLEKRQEALELIKKGYTQQLAFKQPISAYAAFNNRPPSTWLTAMWSRSFSLAANLIAIDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAFVLIALQEARDICEGQVNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMNKLEEPYLTKFLNTAKDRNRWEEPGQQLYNVEATSYALLALLLLKDFDSVPPVVRWLNDERYYGGGYGSTQATFMVFQALAQYRADVPDHKDLNMDVSLHLPSRSSPTVFRLLWESGSLLRSEETKQNEGFSLTAKGKGQGTLSVVTVYHAKVKGKTTCKKFDLRVTIKPAPETAKKPQDAKSSMILDICTRYLGDVDATMSILDISMMTGFIPDTNDLELLSSGVDRYISKYEMDKAFSNKNTLIIYLEKISHSEEDCLSFKVHQFFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHNEMCRCAEENCFMHQSQDQVSLNERLDKACEPGVDYVYKTKLTTIELSDDFDEYIMTIEQVIKSGSDEVQAGQERRFISHVKCRNALKLQKGKQYLMWGLSSDLWGEKPNTSYIIGKDTWVEHWPEAEERQDQKNQKQCEDLGAFTETMVVFGCPN
What is the function of this protein?
Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance.  Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways.  Ligand for C5AR2.  Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (By similarity).
What are the official names of this protein?
Complement C3.
What are the subcellular locations of this protein?
Secreted.
Protein: IPMK_YEAST
Sequence: MDTVNNYRVLEHKAAGHDGTLTDGDGLLIFKPAFPQELEFYKAIQVRDVSRRKSSADGDAPLCSWMPTYLGVLNEGAKIEQSGDAALLKIDERLSDSTDNLDSIPVKSEKSKQYLVLENLLYGFSKPNILDIKLGKTLYDSKASLEKRERMKRVSETTTSGSLGFRICGMKIQKNPSVLNQLSLEYYEEEADSDYIFINKLYGRSRTDQNVSDAIELYFNNPHLSDARKHQLKKTFLKRLQLFYNTMLEEEVRMISSSLLFIYEGDPERWELLNDVDKLMRDDFIDDDDDDDDNDDDDDDDAEGSSEGPKDKKTTGSLSSMSLIDFAHSEITPGKGYDENVIEGVETLLDIFMKF
What is the function of this protein?
Inositol phosphate kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activities.  Able to phosphorylate inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) on both the carbon-3 and carbon-6 positions to synthesize inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) and inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), and then to subsequently phosphorylate and convert either isomer of InsP4 to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:10574768, PubMed:10683435, PubMed:11311242).  Its predominant in vivo catalytic function is to convert Ins(1,4,5)P3 to Ins(1,4,5,6)P4 to Ins(1,3,4,5,6)P5 via 6- and 3-kinase activities (PubMed:15944147).  It can also use Ins(1,3,4,5,6)P5 as a substrate and act as a diphosphoinositol polyphosphate synthase to generate two different isomers of PP-InsP4 (PubMed:11311242).  Has also a role in transcription regulation.  Forms a complex with ARG80, ARG81 and MCM1 (ArgR-MCM1), which coordinates the expression of arginine anabolic and catabolic genes in response to arginine.  Recruits ARG80 and MCM21 to stabilize them (PubMed:3298999, PubMed:8043104, PubMed:10632874).  Neither the kinase activity nor inositol phosphates are required for the formation of ArgR-MCM1 transcriptional complexes on DNA promoter elements and the control of arginine metabolism (PubMed:11119723, PubMed:10720331, PubMed:12828642, PubMed:22992733).  In contrast, only the catalytic activity is required for PHO gene repression by phosphate and for NCR gene activation in response to nitrogen availability, indicating a role for inositol pyrophosphates in these controls (PubMed:12828642).  Inositol polyphosphates may be involved in the regulation of chromatin remodeling of transcription (PubMed:12434012).  Regulates nuclear mRNA export via inositol phosphate metabolism (PubMed:10390371, PubMed:10683435).  Also has lipid kinase activity, transforming the lipid inositol phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) into phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) in the nucleus (PubMed:16123124).  Its kinase activity is necessary for the propagation of most [PSI+] prion variants (PubMed:28923943).
What are the official names of this protein?
Inositol polyphosphate multikinase, IPMK, Arginine metabolism regulation protein III, GLE1 synthetic lethal protein 3, Inositol polyphosphate kinase 2.
What is the protein family that this protein belongs to?
Belongs to the inositol phosphokinase (IPK) family.
Protein: PA1B2_CHICK
Sequence: MSHGDSNPAAVPHAADDIQGDDRWMSQHNRFVSDCKDKEPDVLFVGDSMVQLLQQYEIWRELFSPLHALNFWIGGDTTGHVLWRLKNGELENIKPKVIVVWVGTNNYGNTAEEVAGGIEAIVRLINTQQPQAKVIVLGLLPRGEKPNPLRQKNAKVNHLLKASLPKLPNVQLLDVDAGFVHSDGTISYHDMFDFLHLTGGAYAKICKPLHELIMQLLEETPEEKRAALA
What is the function of this protein?
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF.
What are the official names of this protein?
Platelet-activating factor acetylhydrolase IB subunit alpha2, PAF acetylhydrolase 30 kDa subunit, PAF-AH 30 kDa subunit, PAF-AH subunit beta, PAFAH subunit beta.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORTH2_ARATH
Sequence: MARDIQLPCDGDGVCMRCKSNPPPEESLTCGTCVTPWHVSCLSSPPKTLASTLQWHCPDCSGEIDPLPVSGGATGFESAGSDLVAAIRAIEADESLSTEEKAKMRQRLLSGKGVEEDDEEEKRKKKGKGKNPNLDVLSALGDNLMCSFCMQLPERPVTKPCGHNACLKCFEKWMGQGKRTCGKCRSIIPEKMAKNPRINSSLVAAIRLAKVSKSAAATTSKVFHFISNQDRPDKAFTTERAKKTGKANAASGKIYVTIPPDHFGPIPAENDPVRNQGLLVGESWEDRLECRQWGAHFPHVAGIAGQSTYGAQSVALSGGYKDDEDHGEWFLYTGSGGRDLSGNKRTNKEQSFDQKFEKSNAALKLSCKLGYPVRVVRSHKEKRSAYAPEEGVRYDGVYRIEKCWRKVGVQGSFKVCRYLFVRCDNEPAPWTSDENGDRPRPIPNIPELNMATDLFERKETPSWDFDEGEGCWKWMKPPPASKKSVNVLAPEERKNLRKAIKAAHSNTMRARLLKEFKCQICQQVLTLPVTTPCAHNFCKACLEAKFAGKTLVRERSTGGRTLRSRKNVLNCPCCPTDISDFLQNPQVNREVAEVIEKLKTQEEDTAELEDEDEGECSGTTPEEDSEQPKKRIKLDTDATVSATIR
What is the function of this protein?
E3 ubiquitin-protein ligase.  Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing.  Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11.  Promotes methylation-mediated gene silencing leading, for example, to early flowering.  Associates with methylated DNA, and can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate.  Probably acts at the DNA methylation?histone interface to maintain centromeric heterochromatin.
What are the official names of this protein?
E3 ubiquitin-protein ligase ORTHRUS 2, Protein VARIANT IN METHYLATION 1, RING-type E3 ubiquitin transferase ORTHRUS 2.
What are the subcellular locations of this protein?
Nucleus. Note=Broadly distributed in the nucleus and enriched in the heterochromatic chromocenters.
Protein: FADL_ECOLI
Sequence: MSQKTLFTKSALAVAVALISTQAWSAGFQLNEFSSSGLGRAYSGEGAIADDAGNVSRNPALITMFDRPTFSAGAVYIDPDVNISGTSPSGRSLKADNIAPTAWVPNMHFVAPINDQFGWGASITSNYGLATEFNDTYAGGSVGGTTDLETMNLNLSGAYRLNNAWSFGLGFNAVYARAKIERFAGDLGQLVAGQIMQSPAGQTQQGQALAATANGIDSNTKIAHLNGNQWGFGWNAGILYELDKNNRYALTYRSEVKIDFKGNYSSDLNRAFNNYGLPIPTATGGATQSGYLTLNLPEMWEVSGYNRVDPQWAIHYSLAYTSWSQFQQLKATSTSGDTLFQKHEGFKDAYRIALGTTYYYDDNWTFRTGIAFDDSPVPAQNRSISIPDQDRFWLSAGTTYAFNKDASVDVGVSYMHGQSVKINEGPYQFESEGKAWLFGTNFNYAF
What is the function of this protein?
Involved in translocation of long-chain fatty acids across the outer membrane.  It is a receptor for the bacteriophage T2.  FadL may form a specific channel.
What are the official names of this protein?
Long-chain fatty acid transport protein, Outer membrane FadL protein, Outer membrane flp protein.
What is the protein family that this protein belongs to?
Belongs to the OmpP1/FadL family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.