PharMolix/UniProtQA huggingface dataset:
Protein: SCPA_STAA2
Sequence: MYEVKLDAFNGPLDLLLHLIQKFEIDIYDIPMQALTEQYMQYVHAMKQLEINIASEYLVLASELLMIKSKMLLPQSTSDMDVDDDPREDLVGRLIEYQNYKEYTAILNDMKEERDFYFTKRPTDLSHLETDESWDPNHTIDLTELIVAYQRVKNRVELNTPKSVEIRKETFTIQQATEQVTSRLKDKDHFNFFSLFTFSEPIEQVVTHFLAILEMSKAGIINIEQQRNFEDINIIRGVNYHFG
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: CRTC1_RAT
Sequence: MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSSSMDLSFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTVYLSPPADTSWRRTNSDSALHQSTMTPTQAESFTGGPQDAHQKRVLLLTVPGMEETGSETDKTLSKQSWDSKKAGSRPKSCEVPGINIFPSADQENTAALIPATHNTGGSLPDLSTIHFPSPLPTPLDPEEPPFPALTSSGSTGSLAHLGVGGTGQGMNTPSSSPQRRPAVVSPLSLSTEARRQQAQQVPPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPVSQQQPPPPQVSVGLPQGGPLLPSASLTRGPQLPPLAVTVPSTLPQSPTESPGQPPMGIDVTSAPALQYRTGAGSPATQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMTARQANALSRQLEQFNMMENAISSSSLYNPGSTLNYSQAAMMGLSGSHGGLQDPQQLGYAGHGGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL
What is the function of this protein?
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.  Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.  Enhances the interaction of CREB1 with TAF4.  Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.  Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity).  In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.  May be required for dendritic growth of developing cortical neurons.  In concert with SIK1, regulates the light-induced entrainment of the circadian clock.  In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock (By similarity).
What are the official names of this protein?
CREB-regulated transcription coactivator 1, Mucoepidermoid carcinoma translocated protein 1 homolog, Transducer of regulated cAMP response element-binding protein 1, TORC-1, Transducer of CREB protein 1.
What is the protein family that this protein belongs to?
Belongs to the TORC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain.
Protein: ACCD_SERP5
Sequence: MSWIERILNKSNITQTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARMRLHTLLDEGSEVELGSELEPKDVLKFKDSKKYKDRLVAAQKATGEKDALVVMKGTLYGMPIVAASFEFAFIGGSMSSVVGARFVRAVEQALEDNCPLVCFSASGGARMQEALMSLMQMAKTSAALAKLQERGLPYISVLTDPTMGGVSASLAMLGDINIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPEMRQTLASILSKLTNQPQPHFDEAAPVSEQENQADA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RATA_VIBCH
Sequence: MKQVSRSALVSFSAEQMFHLVNDVARYPEFLPGCSGSCVLEQSEAHMVASVDVSKAGISKTFTTSNQLTPGVSIAMSLVDGPFKTLRGGWFFTPLDEAACKVELRLEFEFSSKMIELAFGKIFNELTSNMVNAFTRRAKQVYGE
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes.  Its antitoxin is unknown (By similarity).
What are the official names of this protein?
Ribosome association toxin RatA.
What is the protein family that this protein belongs to?
Belongs to the ribosome association toxin RatA family.
Protein: RD43_PHYIT
Sequence: MRLAMILLSIPLFVSGNVLHVPTQVTKSHAVSPDAQFVVAMGRRSLRTSGEANEERTRLNTLLLLDDVTEAEMSSIKKLALTFAKLENRNDGAADLFNMLRRQGHTKESARNAGNLYTKYLQNPSAFHT
What is the function of this protein?
Effector that enhances P. infestans colonization of Nicotiana benthamiana leaves.
What are the official names of this protein?
RxLR effector protein PexRD43.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus.
Protein: DNLJ_LATSS
Sequence: MGLAKLVEDYTQSEAASLAQQLRDQLADYSQAYYTQDAPLVEDHVYDELYRDLEQLEAAFPVIVTNDSPTQKVGGQVLPGFTKVTHEIPMLSMGDVFSEAELAAFDQRLRKNTATEIEYNVELKIDGLAIDLIYEKGRFVRGATRGNGTIGEDITQNLKTIKAIPQKLTRPVSIEVRGECYMPKAAFADLNQKREAEGQAPFANPRNAAAGSLRQLDAKVAAARQLSAFIYTIVTFDDVQATTQSEALHVLAELGFNVNPTSVVCQNMAEVQAFIEQYQGTRNDLAYGIDGVVLKVNDLALQRQLGNTVKVPRWEIAYKFPPEEAETVIREIEWTVGRTGVVTPTAVMDPVQLAGTTVARASLHNADMLRDKDVRLLDTVLLHKAGDIIPEISQVVLAKRPSDSQAYGIPTTCPSCGHDLVHLDEEVALRCINPMCPAQMKEQLTHFASRNAMNIDGLGPRIITQLLEKELIHDVADLYRLTADDLAQLDKFKEKSINNLLNAIDASRQNSLERLLFGLGIRHVGAKAARLLAEHFQNLAALMASDQETIITVDTIGTIIADSLVTYFADSQVQTLMAELEAVGVNLTYTGVTKAQAATSDSYFNGKTVVLTGKLEQYTRGELKQLLEDNGAKVTGSVSKKTDALIAGQDAGSKLEKAQSLAIPIINEADLDNYLAQ
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: IFNA6_MOUSE
Sequence: MARLCAFLMVLAVLSYWPTCSLGCDLPQTHNLRNKRALTLLVKMRRLSPLSCLKDRKDFGFPQEKVGAQQIQEAQAIPVLTELTQQILTLFTSKDSSAAWNATLLDSFCNDLHQLLNDLQGCLMQQVEIQALPLTQEDSLLAVRTYFHRITVFLREKKHSPCAWEVVRAEVWRALSSSAKLLARLNEDE
What is the function of this protein?
Produced by macrophages, IFN-alpha have antiviral activities.  Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
What are the official names of this protein?
Interferon alpha-6, IFN-alpha-6, Interferon alpha-8, IFN-alpha-8.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: IHFB_SALAR
Sequence: MTKSELIERLASQQSHIPAKAVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RL17_PECAS
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMASSLVRHEIIKTTLPKAKELRRVVEPLITLAKTDSVANRRLAFARTRDNEIVAKLFNELGPRFASRAGGYTRILKCGFRAGDNAPMAYIELVDRSVSQTEEVATAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: TUSA_YERPS
Sequence: MTDIFANPDKTLDALGLRCPEPVMMVRKTVRHMEEGQTLLIIADDPATTRDIPGFCRFMDHQLLAQDTEQTPYRYLVRKGITAG
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATB_CORJK
Sequence: MFSNVGWGEVLVLLIVALFLIGPERLPGLIKEVRAMLLAVRNAISQAKEQIDGELGEDFREFSKPLQELNSVRQMGAKGFITKTLLDGDDSFLTSFNETKQDVKDTVDTVRKPNLRESLKADKTKKSAQPQPSLASGSADNGGIAVTQQSNAGESRSSHDSPVADAAEQLTGDVGSASEPKEKPSAPGYGWEDVT
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: AROS_MOUSE
Sequence: MSAALVRRGLELLAASEAPRAVPGQVQASGTPAKRTRRARAKASQALKLRNSAKGKAPKSALAEYQKRQCRDHLKANLKFMTSMRSTVPESVTQQILQQNQGRKACDRLVAKTKNKKKKKKKAEGTVFTEEDFQKFQREYFGS
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1.  Direct regulator of SIRT1.  Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.
What are the official names of this protein?
Active regulator of SIRT1, 40S ribosomal protein S19-binding protein 1, RPS19-binding protein 1, S19BP.
What is the protein family that this protein belongs to?
Belongs to the AROS family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL3_METH6
Sequence: MATIHRPRRGSLAFSPRKRAKSQVPRTRYWAAGEEKARMDGFAGYKAGMTHIIMIDDKPNSLTEGMEISVPVTILETPPLSIAALRVYEKYNGGVRAAGEAWSDKLDPSLARSITVPKNKRGAAIDEIGAIIEDMEELRLIAHTNPKLLTGVPKKNPDLMEIQVNGGNIANQFELAKSLLGSSVPISSIFSPGSIIDVSAITKGKGVQGPVKRWGINLQKRKHSRGGKRRHIGNLGPWNPHHVRWTVPLLGQMGYHQRTEFNKRVLAIGSDGGAITPDGGFPGYGIIRGEYAILSGSVPGPSKRLVRMRSAVRAKDADLKTPQVLYVSRDSKQGL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: DNLJ_PROMH
Sequence: MNQNIQQQIDELRVTLRHHEYLYHVMDAPEIPDAEYDRLMNKLKALEAEHPELITPDSPTQRVGALPLTAFEQVRHEIPMLSLDNAFDETTYLAFDKRLRERLKNNEEITFCCELKLDGLAVSLLYENGRLVQAATRGDGTTGENITENVRTIKAIPLRLYGDNIPARIEIRGEVFMTEKGFEHLNEEARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPTSHYARLQQFKKWGLPVSDAIKLCTGTKAVLDFYHHVAEIRPNLGFDIDGVVIKVDDIALQEELGFVSRAPRWAIAYKFQAQEQMTVIKDVEFQVGRTGAITPVARLDPVQVAGVIVSNATLHNADEIERLGLRIGDTVVIRRAGDVIPQVVSVIEEKRPENAQEIVFPTQCPICQSDIERIEGEAVARCTGGLICAAQRKEALKHFVSRRAMDVDGMGDKIIDQLVEKEYVKTPADLFRLDEKILSGLERMGEKSAKKLLNALEKAKSTTFARFIYALGIREVGEATANGLTAHFVSLEALREANIEALKAVPDVGDIVAKHVVNFFQEEHNKNVIDQLVNDIGITWPAPVVATHEAGDNPFAGKTVVLTGSLSQLTRDEAKDRLVALGAKVSGSVSKKTDMVIAGEAAGSKLAKANELGITVIDEDEMIRLLDQSK
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: KC1A_HUMAN
Sequence: MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688).  It can phosphorylate a large number of proteins (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688).  Participates in Wnt signaling (PubMed:11955436).  Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436).  May phosphorylate PER1 and PER2 (By similarity).  May play a role in segregating chromosomes during mitosis (PubMed:1409656).  May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).  Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity).
What are the official names of this protein?
Casein kinase I isoform alpha, CKI-alpha, CK1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).
Protein: TRXO2_ARATH
Sequence: MKSQWSNFHQIGRNSFLAASTVYVSNEFNFLNTSLLNRRSFCFAEGDRSSFVVLKSEAEFNSALSKARDGSLPSVFYFTAAWCGPCRLISPVILELSNKYPDVTTYKVDIDEGGLSNAIGKLNVSAVPTLQFFKGGVKKAEIVGVDVVRLKSVMEQLYK
What is the function of this protein?
Thiol-disulfide oxidoreductase that may participate in various redox reactions.  Possesses insulin disulfide bonds reducing activity.  Reduced by thioredoxin reductases NTRA and NTRB.
What are the official names of this protein?
Thioredoxin O2, mitochondrial, AtTrxo2.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. Plant O-type subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS16_ACIF2
Sequence: MVVIRMARGGAKKRPFYHIVVADSRSRRDGRFIERLGFYNPIGAVAELRIDKERAAYWLSQGAQPSDTVAGFLKKEGVSKTGVASV
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: PYRG_MYCPU
Sequence: MTLRSKMTKYIFVTGGVVSGLGKGVSAASIGNLLKHRGFKIFVLKLDPYLNIDPGVMSPYEHGEVYVTADGGETDLDLGHYERFIDVELSKDSNYTSGKIFSNLFTQERNGNFLGKTVQLIPHFTNEILNTIEKIATKHKPDFMIVEIGGTIGDIESNSFIYAMAELALAKPDRFFLVHVTYVIFLEASNEFKSKPTQVSINSLRSFGISPNLVLLRNSKMVPDNIVEKIAKKSVLNKDYVISVPDMKNIYEAPLYFESQNIAQIILSHFKIKDIEPDLSKWNKLVDSIKKPKAYKAKILMVGKYVEFLDAYKSIIEAFKVSSYEENIDLKMDWVDSSKLELTNLDEFLKGYDGVVILPGFGIRGWEQKVRIAQYTRENKIPTFGICLGFQAMSVAHARMKGIKNANSREFANDKNDETYILDLIQGKAKDKNLGGTLRLGNYTTTIKENTLAKKIYQKDQVIERHRHRYEINSKYIDLLEDEEFVFSGIWNEGKLAEICEVKNHPFYLGVQYHPEFTSRPLKPNPLFTSFLRVLIKNN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: XGPT_RHIL3
Sequence: MSLPDKAFPVSWDQFHRDARALAWRLAGLNQTFKAIVCITRGGLVPAAIISRELNIRLIETVCVASYHDYVNQGDMVLLKGIAPELMENGGETVLVVDDLTDTGKTAAQVRTMLPRAHFACVYAKPKGVPTVDTFITEVSQDTWIYFPWDMGFTYQEPIAKGAG
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LAM0_DROME
Sequence: MSSKSRRAGTATPQPGNTSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQKWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAVDGNEQLYHQQGDPQQSNEKCAIM
What is the function of this protein?
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (PubMed:3126192, PubMed:15035436).  May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane (PubMed:15035436, PubMed:16439308).  In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle (PubMed:27402967).  Required for nuclear migration and to link the microtubule organizing center (MTOC) to the nucleus (PubMed:14617811).  In addition, is required for nuclear envelope localization of klar (PubMed:14617811).
What are the official names of this protein?
Lamin Dm0.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Nucleus. Nucleus inner membrane. Nucleus envelope. Nucleus lamina. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm. Note=Nuclear periphery (PubMed:7593280). At metaphase and anaphase, weakly expressed in the nuclear envelope and spindle poles (PubMed:16439308). Expression in oocyte cytoplasm increases after stages 6 to 7 of egg development (PubMed:9199347). In spermatocytes detected at the spindle envelope, spindle poles and astral membrane throughout meiosis I, whereas mostly depleted in meiosis II (PubMed:27402967). Colocalizes with nuclear pore complex component Nup107 throughout meiosis I (PubMed:27402967).
Protein: SCOC_MOUSE
Sequence: MSKMDGLSTGEEEDSTFTSISLEDDTDHSLKSWRSRAESLLPKMMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAVKEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK
What is the function of this protein?
Positive regulator of amino acid starvation-induced autophagy.
What are the official names of this protein?
Short coiled-coil protein.
What is the protein family that this protein belongs to?
Belongs to the SCOC family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm, cytosol.
Protein: HDRA1_METAC
Sequence: MTDGLNKAAVFICHCSGNISEHVDIDAVKKTLKAEGISVFDYEYMCSSQGQALIKKKIVEGSLDRVVIGSCTPSKHGTLFKKCIQETGLNRAGLEIANLREQCAWVHPDRTGATEKALSLLRAKLKRLENVEPLDEIKVDIAQQALVIGGGIAGITAALNLADNGVSTVLVENNSSIGGQMAKIGKIFSPDKLAEECAMCSLSPLMNEVAAHPKITLLTRTEVESLSGSAGNFTIRLRKKPRYVKDSCTACGRCSRVCPVQVEDEFNCGHMDKKAISLRFSQSVPKIYCIDPDYCLQLNGEACGKCADACKNEAIDFSQKEEIVELNVGAVVVATGFEEYDVSQKPQYGYGIFENVLTQMELARVLGINGPTKGELLRVSDFSKASSDPTPATCDSRCEDSSDESQGTDTPKRIVMIQCVGSRDEKEGGNRYCSRYCCMAALKHASLIKKKHPETEITICYIDVRAFGFYENYYRAVQETGVNFVRGRPAEVIEKPDKSLVVRVEDTLDQKMRELPADLVVLSAAMVPSPGTRKIASVLNLSQDESGFIKERHSKLKPVDSSLDGIFVCGTAQSPKDVTDTIAQAGLAAVRARAFITDSPKVLDNEIATINQLLCTRCGECLKCPFDALSVNESGRVVLDPLICTGCGYCTKLCGEGAVQIAGFTKLQLKAEMEGVLEEGDVLGFVNSGIASLTCDNIGNSVLTYPSNVKLIKVPTGLVVDRDLVLHAFRHGASSVLFVEDPPDNPRAEVIYPLTVSHFEELKEELGDSGNRIYFKKAYVPNTKGLAGTFTSLAREGEMIR
What is the function of this protein?
Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).  Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis.
What are the official names of this protein?
Ferredoxin:CoB-CoM heterodisulfide reductase subunit A.
What is the protein family that this protein belongs to?
Belongs to the HdrA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPHB_PYRNV
Sequence: MFYIIGVGPAPGFITEKAAQILREADCVFYEDYTGPIDVETLRRYARSPPTRLTRRDLEDESGRRVLECLSRGKTAVLATAGDPMLATSHAALISIARSRGYSVEVVPGVSIVCAAFSASCLSIYKLGGVATVTYPRGGVYSARPYELVEQNLARGLHTLLLLDVREDGVFMPPRDAAEIMLKLEEREKRGVFDKGRPVVVVPKLGWGGRPAYLPLGELLGSDLEGPAVFIVPGGLSPVERECIEALSVLKSR
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.