PharMolix/UniProtQA huggingface dataset:
Protein: HOOK2_MOUSE
Sequence: MSVDKAELCGSLLTWLQTFQVSPPCASPQDLSSGLAIAHVLNQIDPSWFNNEWLQGISEDSSPSWRLKVRKLEKILQSLVEYSKNVLGHPVSDQHLPDVSLIGEFSNPAELGKLLQLVLGCAISCEKKQEYIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPENYGNFDTQSRRYYFLSEEVEEGDHLQQHYLDLERQLLLLSEEKQNLAQENAALRERVGRSEVESAPGLTAKKLLLLQSQLEQLQEENFRLESSREDDRLRCLELEREVAELQQRNQALTSLSQEAQALKDEMDELRQSSERARQLEATLNSCRRRLGELQELRRQVRQLEERNAGHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGQWQEEAMKAEKWLFECRNLEEKCDLVTKEKERLLTERDSLREANEELRCAQLQPRGLAQADLSLDPTPSGLENLAAEILPAELRETLVRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLEAQQRLNQQQLSELRAQVEELQKALQEQGGKTEDPTLLKRKLEDHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQDSLQKKDADLRAMEERYRRYVDKARTVIQTLEPKQRPPTVVSPEFHTLRSQLWERNLRIRQMEMDYEKSRRRQEQEEKLLISAWYSMGMALEHRAGEEHAPAHAQSFLAQQRLATNARRGPLGRQALSLRPTDKH
What is the function of this protein?
Component of the FTS/Hook/FHIP complex (FHF complex).  The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).  Contributes to the establishment and maintenance of centrosome function.  May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.  FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
What are the official names of this protein?
Protein Hook homolog 2, mHK2.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Golgi apparatus, trans-Golgi network. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Localizes to the manchette in elongating spermatids (PubMed:28003339).
Protein: SPE1_SOLLC
Sequence: MPLVVRFPDVLKNRLETLQSAFDMAINSQGYEAHYQGVYPVKCNQDRFVVEDIVKFGSPYRFGLEAGSKPELLLAMNCLSKGSADALLVCNGFKDTEYISLALVARKLLLNSVIVLEQEEELDLVIDISRKMSVRPVIGLRAKLRTKHSGHFGSTSGEKGKFGLTTTQILRVVKKLDESGMLDCLQLLHFHIGSQIPTTELLADGVGEATQIYSELVRLGAGMKFIDIGGGLGIDYDGSKSSNSDVSVCYSIEEYASAVVQAVLYVCDRKGGKHPVICSESGRAIVSHHSILIFEAVSASTSHVSTQPSSGGLQSLVETLNEDARADYRNLSAAAVRGEYDTCLIYSDQLKQRCVEQFKDGSLDIEQLAAVDSICDWVSKAIGVADPVRTYHVNLSVFTSIPDFWGFSQLFPIVPIHRLDEKPTMRGILSDLTCDSDGKVDKFIGGESSLPLHEIGSGDGGRYYLGMFLGGAYEEALGGLHNLFGGPSVVRVMQSDSPHSFA
What are the official names of this protein?
Arginine decarboxylase, ADC, ARGDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: TRAI_SINFN
Sequence: MQILAISKPRNIEEAQLLRSHHELRARVFSDRLGWEVNVVGGCESDTFDDLQPTYILAVSSNDRVVGCARLLPALGPTMVANVFPSLLSAGHLNAHSSMVESSRFCVDTFLAESRGDGSIHEATLTMFAGIIEWSVANRYTEIVTVTDLRFERILARVGWPLQRIGEPRPIGATVAVAGTLPAKADTFMRLRPANYRSQIISTFGQSA
What is the function of this protein?
Required for the synthesis of OHHL (N-(3-oxooctanoyl)-L-homoserine lactone), an autoinducer molecule which binds to TraR and thus acts in the control of conjugal transfer.
What are the official names of this protein?
Probable acyl-homoserine-lactone synthase, Autoinducer synthesis protein TraI.
What is the protein family that this protein belongs to?
Belongs to the autoinducer synthase family.
Protein: RSMA_FRAT1
Sequence: MQYKTKAKKSLGQNFLQDENIIRKIVQLANIKKHDIVVEIGPGLGALTRYLLSSSNNVSVVEFDASVIDTLIANCQKYGTPHIYNQDFLKFDISSLENSSNQKIKLIGNLPYNISSPILFKVIKDSDKIVDAHFMLQKEVVERIVSLPNSKSSGRLSVILQYHFDCSMILKIPPEVFYPQPKVDSAILRLKPKNSKELLKNYNFFEEIVKQSFAQRRKTLHNNLKSILKERKIDPSTLPVDTNLRAENLSVGDFVSLANFLS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_ACET2
Sequence: MRVLGIDYGDSRIGIAISDPLGWTAQALETITWRSDVEVPLKRISELVEEYGVKTVIVGFPKNMDGTVGARGEKTIEFIDLLQQRIKDIEVIKWDERLTTVAANRTMYEMGIKKSKKKLVVDQIAAVYILQGYLDSKGKVL
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PARB_CAUVN
Sequence: MESVVVGEPGMSEGRRGLGRGLSALLGEVDAAPAQAPGEQLGGSREAPIEILQRNPDQPRRTFREEDLEDLSNSIREKGVLQPILVRPSPDTAGEYQIVAGERRWRAAQRAGLKTVPIMVRELDDLAVLEIGIIENVQRADLNVLEEALSYKVLMEKFERTQENIAQTIGKSRSHVANTMRLLALPDEVQSYLVSGELTAGHARAIAAAADPVALAKQIIEGGLSVRETEALARKAPNLSAGKSKGGRPPRVKDTDTQALESDLSSVLGLDVSIDHRGSTGTLTITYATLEQLDDLCNRLTRGI
What is the function of this protein?
Involved in chromosome partition.  Localize to both poles of the predivisional cell following completion of DNA replication.  Binds to the DNA origin of replication.
What are the official names of this protein?
Chromosome-partitioning protein ParB.
What is the protein family that this protein belongs to?
Belongs to the ParB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Subcellular distribution changes during the cell cycle. In swarmer cells, where DNA replication does not occur, ParB is for the most part distributed throughout the cell. As DNA replication proceeds, ParB begins to concentrate at one pole of the predivisional cell. Finally, in late predivisional cells, following the completion of DNA replication, ParB is distributed to both poles of the cell.
Protein: OIT3_MOUSE
Sequence: MPLSLLLTCLSTTVTLVSPAVLDPCSAYISLNEPWRNTDHQFDESQNQPLCDNHMNGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEEDGIVQRQACASFKGNCCLWNATVEVKACPRGYYVYRLARPSVCFHVYCGHFYDICDEDCHGNCLDTTECACSPGTSLGPDGQTCFDENECEHNNGGCSEICVNLKNSHRCACGVGRVLRSDGKTCEDIEGCHNNNGGCSHSCLGSEEGYQCECPRGLVLSEDNHTCQVPVLCKSSAIEVSVPRELVGGLELFLTNTSCRGVSNGTHVNIVFSLKTCGTVVDVVNDKIVASNIVTGLPKETPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNAPLEIRSRNHGIFPFTLEIFKDHEFEEPYRETLPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTAKMDEILKYYLIQDGCVSDDSVKQYSSRDHLAKHFQAPVFKFVGKDHKEVFLHCRVLVCGVLDERSRCAQGCHRRVRREVGEDEDSAGLQSQTLTGGPIAIDWED
What is the function of this protein?
May be involved in hepatocellular function and development.
What are the official names of this protein?
Oncoprotein-induced transcript 3 protein, Liver-specific zona pellucida domain-containing protein.
Protein: DEOC_THEMA
Sequence: MIEYRIEEAVAKYREFYEFKPVRESAGIEDVKSAIEHTNLKPFATPDDIKKLCLEARENRFHGVCVNPCYVKLAREELEGTDVKVVTVVGFPLGANETRTKAHEAIFAVESGADEIDMVINVGMLKAKEWEYVYEDIRSVVESVKGKVVKVIIETCYLDTEEKIAACVISKLAGAHFVKTSTGFGTGGATAEDVHLMKWIVGDEMGVKASGGIRTFEDAVKMIMYGADRIGTSSGVKIVQGGEERYGG
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RARR2_MOUSE
Sequence: MKCLLISLALWLGTVGTRGTEPELSETQRRSLQVALEEFHKHPPVQLAFQEIGVDRAEEVLFSAGTFVRLEFKLQQTNCPKKDWKKPECTIKPNGRRRKCLACIKMDPKGKILGRIVHCPILKQGPQDPQELQCIKIAQAGEDPHGYFLPGQFAFSRALRTK
What is the function of this protein?
Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1).  Acts also as a ligand for CMKLR2.  Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2.  Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue.  Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues.  Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases.  Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells.  Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells.  The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production.  Exhibits an antimicrobial function in the skin.
What are the official names of this protein?
Retinoic acid receptor responder protein 2, Chemerin.
What are the subcellular locations of this protein?
Secreted.
Protein: CCME_RHOP2
Sequence: MTRKQRRLMMIGGAGVVLVVAVGLVLNAMRGSIVFFSTPKMVHEQNIEAGKRFRLGGVVEPGSLTRGDQLAVAFKVSDGDATVPVAFKGILPDLFREGQGVIAEGALDTAGVFKADTVLAKHDETYMPKDVADALKKQGHWKDDYEKKPPGPGAAASADAMRPAR
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: LEF1_MOUSE
Sequence: MPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGHEVVRQAPSSQEPYHDKAREHPDEGKHPDGGLYNKGPSYSSYSGYIMMPNMNSDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPEIPTFYPLSPGGVGQITPPIGWQGQPVYPITGGFRQPYPSSLSGDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGTGPRMTAAYI
What is the function of this protein?
Transcription factor that binds DNA in a sequence-specific manner (By similarity).  Participates in the Wnt signaling pathway (PubMed:11445543).  Activates transcription of target genes in the presence of CTNNB1 and EP300 (PubMed:12446687).  PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (PubMed:11731474).  TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity).  Regulates T-cell receptor alpha enhancer function (By similarity).  Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (PubMed:23562159).  May play a role in hair cell differentiation and follicle morphogenesis (PubMed:11445543).
What are the official names of this protein?
Lymphoid enhancer-binding factor 1, LEF-1.
What is the protein family that this protein belongs to?
Belongs to the TCF/LEF family.
What are the subcellular locations of this protein?
Nucleus. Note=Found in nuclear bodies upon PIASG binding.
Protein: CCR5_SAISC
Sequence: MDYQVSSPIYDIDYGPSEPCRKIDVKQMGAQLLPPLYSLVFLFGFVGNMLVVLILINCKRLKSMTDIYLLNLAISDLLFLFTIPFWAHYAAGQWDFGNTMCQFLTALYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGYHYSCSPHFPFSQYRFWKNFETLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLINTYPDFFGVNNCNSSNRLDQAMQVTETLGMTHCCVNPIIYAFVGEKFRNYLVIFFQKHIAKRFCKCCSIFQKEAPERANSVYTRSTGEQEISVGL
What is the function of this protein?
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.  May play a role in the control of granulocytic lineage proliferation or differentiation.  Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
What are the official names of this protein?
C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KIP2_YEAST
Sequence: MIQKMSPSLRRPSTRSSSGSSNIPQSPSVRSTSSFSNLTRNSIRSTSNSGSQSISASSTRSNSPLRSVSAKSDPFLHPGRIRIRRSDSINNNSRKNDTYTGSITVTIRPKPRSVGTSRDHVGLKSPRYSQPRSNSHHGSNTFVRDPWFITNDKTIVHEEIGEFKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMSGNEQELGLIPLSVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSRISTPSRLYMSKSNSNGLGVELKIRDDSQYGVKVIGLTERRCESSEELLRWIAVGDKSRKIGETDYNARSSRSHAIVLIRLTSTNVKNGTSRSSTLSLCDLAGSERATGQQERRKEGSFINKSLLALGTVISKLSADKMNSVGSNIPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPALSGDSIVTTICTVDTRNDAAAETMNTLRFASRAKNVALHVSKKSIISNGNNDGDKDRTIELLRRQLEEQRRMISELKNRSNIGEPLTKSSNESTYKDIKATGNDGDPNLALMRAENRVLKYKLENCEKLLDKDVVDLQDSEIMEIVEMLPFEVGTLLETKFQGLESQIRQYRKYTQKLEDKIMALEKSGHTAMSLTGCDGTEVIELQKMLERKDKMIEALQSAKRLRDRALKPLINTQQSPHPVVDNDK
What is the function of this protein?
Required for assembly of the mitotic spindle.
What are the official names of this protein?
Kinesin-like protein KIP2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SRG8_CAEEL
Sequence: MSGNSSTPNQGINCDPSYSYVMENFKYFVQVAYLAPAVFLYSRILYVVWVQHKKSYGYHPFFMVYSMVGLILVLLDIFITRLFVYVPQLCLPAAQFFISNPFLMELYYPLLNYLHCAQPFIQIFLTTNRMSSVLWPVDHEKFWKINFSRILILNLIAPFFFIWNTIISKKVLIFYFGGFYINYLKIIPWASMSLFLFIIRSAVVMITVVTTSITFWKMSHMKNRLKKSEGTLCKACAANSICFLVPAVFEAMKVLNTDWGKHWLAYLVQPFAWDVLNVGSPLVMIFASGQLRTHAFNIKRPVLKRSNSILVSSMTN
What are the official names of this protein?
Serpentine receptor class gamma-8, Protein srg-8.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein srg family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YTXK_BACSU
Sequence: MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKTDQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTIGLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIAYAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSFAHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFKDEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK
What are the official names of this protein?
Uncharacterized protein YtxK.
What is the protein family that this protein belongs to?
To type I restriction system adenine methylases.
Protein: CRY1_DROME
Sequence: MATRGANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDIDDQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQLPTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLKVEQHAFERGFYLPNQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKSLRNSLITPPPHCRPSNEEEVRQFFWLADVVV
What is the function of this protein?
Blue light-dependent regulator that is the input of the circadian feedback loop.  Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts.  Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms.  Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells.  Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry.  Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate.  Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.
What are the official names of this protein?
Cryptochrome-1, DmCRY1, dcry, Blue light photoreceptor.
What is the protein family that this protein belongs to?
Belongs to the DNA photolyase class-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Nuclear translocation initiates after the perception of a light signal. Accumulates in the perinuclear region about one hour before translocation into the nucleus. Translocation occurs through interaction with other Clock proteins such as tim and per.
Protein: GRPE_BURO0
Sequence: MENTQENPTTPSAEDIGSEKQAAQGAAPAAEAADAALAEAQAKVAELQESFLRAKAETENVRRRAQDDVSKAHKFAIESFAEHLLPVLDSLEAAVNDTSGDIAKVREGVELTLRQLTSALEKGRVVAINPIGEKFDPHQHQAISMVPAEQEPNTVVSVLQKGYTIADRVLRPALVTVAQPK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
Protein: TRPD_AZOC5
Sequence: MERFRPLLNKVAMGTALNRDEAAYAFDKMMSGETTPSQMGALLMGLRVRGETVDEIVGAVSVMRAKMLTVDAPVGSVDVVGTGGDASGSYNISTCASFIVAGAGVPVAKHGNRALSSKSGAADVLAALGVRIDLAPAAISRCIAETGIGFMFAPTHHPAMKNVGPTRVELGTRTIFNLLGPLSNPAGVKRQMVGVFAKAWLSPLAEVLKALGSERAWVVHGSDGLDEITISGTTDVASLEDGRVHTFEISPEDVGLTRAAPEALRGGDAEHNAAALRAVLEGAPGAYRDVAVMNAGAALLISGRAASLRDGVDMAKASIDSGAAKAKLDQLARATQALAPQVDA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: NHAB_ECOHS
Sequence: MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMTSAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRHQRTRQDKIRLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLSSISDNVFVGTIYINEAKAAMESGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TPS9_ARATH
Sequence: MVSRSCANFLDLASWDLLDFPQTQRALPRVMTVPGIISELDGGYSDGSSDVNSSNSSRERKIIVANMLPLQAKRDTETGQWCFSWDEDSLLLQLRDGFSSDTEFVYIGSLNADIGISEQEEVSHKLLLDFNCVPTFLPKEMQEKFYLGFCKHHLWPLFHYMLPMFPDHGDRFDRRLWQAYVSANKIFSDRVMEVINPEEDYVWIHDYHLMVLPTFLRKRFNRIKLGFFLHSPFPSSEIYRTLPVRDDLLRGLLNCDLIGFHTFDYARHFLSCCSRMLGLDYESKRGHIGLDYFGRTVFIKILPVGIHMGRLESVLNLPSTAAKMKEIQEQFKGKKLILGVDDMDIFKGISLKLIAMERLFETYWHMRGKLVLIQIVNPARATGKDVEEAKKETYSTAKRINERYGSAGYQPVILIDRLVPRYEKTAYYAMADCCLVNAVRDGMNLVPYKYIICRQGTPGMDKAMGISHDSARTSMLVVSEFIGCSPSLSGAIRVNPWDVDAVAEAVNLALTMGETEKRLRHEKHYHYVSTHDVGYWAKSFMQDLERACREHYNKRCWGIGFGLSFRVLSLSPSFRKLSIDHIVSTYRNTQRRAIFLDYDGTLVPESSIIKTPNAEVLSVLKSLCGDPKNTVFVVSGRGWESLSDWLSPCENLGIAAEHGYFIRWSSKKEWETCYSSAEAEWKTMVEPVMRSYMDATDGSTIEYKESALVWHHQDADPDFGACQAKELLDHLESVLANEPVVVKRGQHIVEVKPQGVSKGLAVEKVIHQMVEDGNPPDMVMCIGDDRSDEDMFESILSTVTNPDLPMPPEIFACTVGRKPSKAKYFLDDVSDVLKLLGGLAAATSSSKPEYQQQSSSLHTQVAFESII
What are the official names of this protein?
Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 9, Trehalose-6-phosphate synthase 9, AtTPS9.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the trehalose phosphatase family.
Protein: ERYI_BRUA2
Sequence: MKVAVAGDSAGEGLAKVLADHLKDRFEVSEISRTDAGADAFYANLSDRVASAVLDGTYDRAILVCGTGIGVCIAANKVPGIRAALTHDTYSAERAALSNNAQIITMGARVIGAEVAKTIADAFLAQTFDENGRSAGNVNAINEVDAKYNKF
What is the function of this protein?
Catalyzes the isomerization of D-erythrulose-4P to D-erythrose-4P.  Involved in the degradation pathway of erythritol, that allows B. abortus to grow on this compound as the sole carbon source.
What are the official names of this protein?
D-erythrulose-4-phosphate isomerase, D-erythrose-4-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LacAB/RpiB family.
Protein: LGUL_BRAJU
Sequence: MASEAKESPANNPGLSTVRDEATKGYIMQQTMFRVKDPKASLDFYSRVLGMSLLKRLDFSEMKFSLYFLGYEDTSTAPTDPTERTVWTFGRPATIELTHNWGTESDPEFKGYHNGNSEPRGFGHIGVTVDDVHKACERFEQLGVEFVKKPHDGKMKNIAFIKDPDGYWIEIFDLKTIGTTAGNAA
What is the function of this protein?
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
What are the official names of this protein?
Lactoylglutathione lyase, Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase.
What is the protein family that this protein belongs to?
Belongs to the glyoxalase I family.