PharMolix/UniProtQA huggingface dataset:
Protein: RS18_SHEON
Sequence: MARYFRRRKFCRFTAEGVAEIDYKDIVTLKNYITESGKIVPSRITGTSAKYQRQLARAIKRARYLSLLPYTDLHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: DAPB_CHLPN
Sequence: MGSSMHVGVIGCSGRTGKVIVSALEQSSEYTLGPGFSRSSALTLFQVIAHNDVLVDFSHPLLTKEVVAHLLISPKPLIIGTTGFPGKCKEAHDSLEELTHIVPVVVCPNASLGAYIHKRLVMLLSQLCNPQFDIRIRETHHRYKKDSLSGTAQDLLDTIQQVKQEDWGEEYEVGQRDSSKKTIEVQSSRVGDIPGEHEVAFISSGEQILVRHTVFSRNVFGRGILSILDWLKTLNPQPGLYSLGDTLELVLRNEHCLLKKTTDH
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y391_POLSJ
Sequence: MWFSRKQVVKPPPDGSRAQPGQVTTKSRGDAAESAAQVFLARAGLIPVESNYRTPGRGGGEIDLVMRTPDGTLVFVEVRQRSGASHGGAAASISPAKQQRIIFAARHYLMRFASPPPCRFDVVLVHGGPGQGPVENGRLEWLPAAFDAS
What are the official names of this protein?
UPF0102 protein Bpro_0391.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RS14_DICDI
Sequence: MSGKKEVKAPKVVEALSAKIPCGPSELVFGVAHIFASFNDTFVHVTDLSSKETIVRVTGGMKVKTDRDESSPYAATMAAQDVALRCKELGVTALHIKLRATGGNGSKTPGPGAQSALRALARSGMRIGRIEDVTPIPTDSTRRKSGHRGRRL
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: YCEO_ECOLI
Sequence: MRPFLQEYLMRRLLHYLINNIREHLMLYLFLWGLLAIMDLIYVFYF
What are the official names of this protein?
Uncharacterized protein YceO.
Protein: MTNB_AZOVD
Sequence: MSPTRAQLTRQIIEAGRFLYGRGWSPATSSNYSARLSPGEALLTVSGKHKGQLGEDDVLATDMAGNSLEPGKKPSAETLLHTQLYTWKTEIGAVLHTHSVNATVLSRLILSDSLVFADYELQKAFAGIGTHECQICVPIFDNDQDIARLASRVRPWLDEHPDCVGYLIRGHGLYTWGAAMNDALRQVEAFEFLFDCELKMRALQGR
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: GLMS_SYMTH
Sequence: MCGIVGYIGRREALPVLMDGLQRLEYRGYDSAGVALVAGGRTWVEKRKGRLSDLQTVLGNLPSGCRVGIGHTRWATHGRPSDRNAHPHTDTSGRFAVVHNGIIENYAELRAELERQGCVFRSETDTEVIPHLIASCYDGDLVRAVRRAVPRLRGAYAIAVVCQQEPDKIVAVRAASPLVIGLGEGELLLASDIPALLPYTRQVIVMEEGWLAELTPEGVTLTTVAGEPVQPQVMRVDWEPGQAERGGYAHFMLKEIHEQPRALRDTLTGRLDAATGLVTLSEVGLSAAEVRALRKVAMVACGTAAHAGLVGRYLIERLAGIPVEWDLASEYRYREPLVDEHTLFVAVSQSGETADTLAALREARSRGARVLAVTNVVGSTVAREADWVLYTWAGPEIAVASTKAYSTQVVALTLLAIWLGQQNGRIDPAEASALVSGLQHLPDQAGQTLSLEAAVKEAAEALAGHDDVFFIGRNLDYAVALEAQLKLKEISYIHAEAYAAGELKHGPLALITDGVPVVALNTQPDLAEKTISNIQETRARGAFVLGLAQEGDEETARHCDRIFYLPRTHRLLTPALAVIPMQLLAYYAATARGTDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_VIBVY
Sequence: MDLLLTNARLVTLQSGEMGYQPSTPMSIGIKAGKIHYLGIDTALAATKQIDLKGKLVTPGLIDCHTHLVYAGNRSNEFEMRLQGVPYQEIARQGGGILSTVYGTRQASEAQLLEQTLPRLDGLLASGVTSVEIKSGYGLTLVDEIKMLRVAKSLSQHRLVKVTPTLLAAHALPPEFTGRANDYIEFICQEIIPVVAEEQLATSVDVFCESIGFDLAQTERVYACAVDHGLRVKGHTEQLSNLGGTALTARYQGLSADHIEFLDRAGVEALARSSTVATLLPGAFYFLRETQLPPIELLRQFGVPMAIASDVNPGTSPFCDLTLMMNMACTLFRLTPEEALRGVTQHAAQALGYAESRGQIKTGYDADLAIWQIEHPADLSYQVGTQRLFARVVDGQFEQHKECCDE
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TNR16_HUMAN
Sequence: MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
What is the function of this protein?
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4.  Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).  Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity).  Can mediate cell survival as well as cell death of neural cells.  Plays a role in the inactivation of RHOA (PubMed:26646181).  Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity).  Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Cell projection, dendritic spine.
Protein: CITX_ECO81
Sequence: MHLLPELASHHAVSIPELLVSRDERQARQHAWLKRHPVPLVSFTVVAPGPIKDSEVTRRIFNHGVTALRALAAKQGWQIQEQAALVSASGPEGMLSIAAPARDLKLATIELEHSHPLGRLWDIDVLTPEGDILSRRDYSLPPRRCLLCEQSAAVCARGKTHQLTDLLNRMEALLNDVDACNVN
What is the function of this protein?
Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.
What are the official names of this protein?
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, Apo-ACP nucleodityltransferase, Holo-ACP synthase, Holo-citrate lyase synthase.
What is the protein family that this protein belongs to?
Belongs to the CitX family.
Protein: GCSP_BRUAB
Sequence: MTEFLPFVARHIGPRHEDERAMLAALGLPSMETLITQAVPAPIRLNRALNLPAALSEADALAELGTIMGRNVVKKSFIGAGYHGVHTPPVIQRNLFENPAWYTAYTPYQSEISQGRLELLFHFQTLVAELTGLPVACASLLDEATAVAEAIGVACRHHRDKRSRILLAGELHPQTVDVVNTRAEPLGWEIATGSDVDDNTAAIVVPWPDTRGVYGDFAKVIADAKAKGALVIAVADPLALTIMEAPARWGADMAVGSMQRYGVPMGFGGPHAAYLAVSEALTRIIPGRIVGQSVDAHGRAAYRLALQTREQHIRRDKATSNICTAQALLANMAAAFAIWHGPAGLQAIATRVAALAARFAAALKAAGVEIAGESLFDTVTAKVPGKAAAIAAEADKGGRLIRIIDADTVGVTFDETSTEEDLTALASLFGAKPVGGDTVLVPGKERGEGFLTQEVFHSHRSETEMMRFLRRLADKDLALDRAMIPLGSCTMKLNAAAEMMPVSWNTVANLHPFAPAEQVQGYAKMTSDLEAWLCEITGFAGVSLQPNAGSQGEYAGLMAIRHYHQARGQGHRNICLIPSSAHGTNPASASMAGMSVVVVNCRPDGDIDIDDLKAKAEKHRDNLAAFMITYPSTYGVFEEGIKAFCEIVHDNGGQVYFDGANLNALVGLARPADIGADVCHMNLHKTFCIPHGGGGPGVGPIGVAKHLVPYLPGHVEAGSEHAVAAAQFGSASILVITWMYIRMMGGAGLKKATEAAILNANYIAHRLKGVYPILYTGAHDRVAHECIVDTRVLKDSAGITVEDVAKRLIDYGFHAPTMSWPVAGTLMIEPTESEPKLEIDRLCDAMIAIAGEAKKVADGVWPADDNPLANAPHTASDTLATEWKHPYTREEAVFPGGAFDPTAKYWPPVSRVDNVGGDRNLICSCPPVATYG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: TR150_HUMAN
Sequence: MSKTNKSKSGSRSSRSRSASRSRSRSFSKSRSRSRSLSRSRKRRLSSRSRSRSYSPAHNRERNHPRVYQNRDFRGHNRGYRRPYYFRGRNRGFYPWGQYNRGGYGNYRSNWQNYRQAYSPRRGRSRSRSPKRRSPSPRSRSHSRNSDKSSSDRSRRSSSSRSSSNHSRVESSKRKSAKEKKSSSKDSRPSQAAGDNQGDEAKEQTFSGGTSQDTKASESSKPWPDATYGTGSASRASAVSELSPRERSPALKSPLQSVVVRRRSPRPSPVPKPSPPLSSTSQMGSTLPSGAGYQSGTHQGQFDHGSGSLSPSKKSPVGKSPPSTGSTYGSSQKEESAASGGAAYTKRYLEEQKTENGKDKEQKQTNTDKEKIKEKGSFSDTGLGDGKMKSDSFAPKTDSEKPFRGSQSPKRYKLRDDFEKKMADFHKEEMDDQDKDKAKGRKESEFDDEPKFMSKVIGANKNQEEEKSGKWEGLVYAPPGKEKQRKTEELEEESFPERSKKEDRGKRSEGGHRGFVPEKNFRVTAYKAVQEKSSSPPPRKTSESRDKLGAKGDFPTGKSSFSITREAQVNVRMDSFDEDLARPSGLLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLHERFTKYLKRGTEQEAAKNKKSPEIHRRIDISPSTFRKHGLAHDEMKSPREPGYKAEGKYKDDPVDLRLDIERRKKHKERDLKRGKSRESVDSRDSSHSRERSAEKTEKTHKGSKKQKKHRRARDRSRSSSSSSQSSHSYKAEEYTEETEEREESTTGFDKSRLGTKDFVGPSERGGGRARGTFQFRARGRGWGRGNYSGNNNNNSNNDFQKRNREEEWDPEYTPKSKKYYLHDDREGEGSDKWVSRGRGRGAFPRGRGRFMFRKSSTSPKWAHDKFSGEEGEIEDDESGTENREEKDNIQPTTE
What is the function of this protein?
Involved in pre-mRNA splicing.  Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC).  Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition.  May be involved in nuclear mRNA decay.  Involved in regulation of signal-induced alternative splicing.  During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells.  Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.  Involved in response to DNA damage.  Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex.  Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit.  Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand.  May play a role in the terminal stage of adipocyte differentiation.  Plays a role in the positive regulation of the circadian clock.  Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
What are the official names of this protein?
Thyroid hormone receptor-associated protein 3, BCLAF1 and THRAP3 family member 2, Thyroid hormone receptor-associated protein complex 150 kDa component, Trap150.
What is the protein family that this protein belongs to?
Belongs to the BCLAF1/THRAP3 family.
Protein: HEM6_SHEPW
Sequence: MSIPDSSVVKAFLLELQNNICNGLEALDGVASFKEDSWKREEGGGGQSRVLTGGKVFEQAGVNFSHVMGASMPASATAHRPELAGRNFEAMGVSLVIHPNNPHIPTTHANVRFFIAHKEGTDPIWWFGGGFDLTPYYPYLEDVVSWHQSAKALCEPFGDETYPKYKKWCDEYFWLPHRNETRGVGGLFFDDLNKQGFDKSFDFMQAVGNGFLTAYAPIVERRKETEYGEHERQFQLYRRGRYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWEYAYIPEAGSPEAALYSDYLKPRDWLSL
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGB_SALNS
Sequence: MSELLSVALFLASVLIYAWKAGRNTWWFAATLTVLGLFVILNITLYASDYFTGDGINDAVLYTLTNSLTGAGVGKYILPGIGIALALVAVFGALGWILRRRRHHPHHVGYSLLALLLALGSVDASPAFRQITELVKSQMRDGDPDFAVYYKEPAKTIPNPKLNLVYIYGESLERTYFDNDAFPNLTPELGALKNEGLDFSHTMQLPGTDYTIAGMVASQCGIPLFAPFEGNASASVSSFFPQNICLGDILKNSGYQNYFVQGANLRFAGKDVFLKSHGFDHLYGAEELKTVVADPSYRNDWGFYDDTVLDEAWKKFEALSRSGQRFSLFTLTVDTHHPDGFISRTCNRKRYDYDGKPNQSFSAVSCSQENIAEFINKIKASPWFKDTVIVVSSDHLAMNNTAWKYLNKQDRNNLFFILRGDKPQQETLAVKRNTMDNGATVLDILGGDNFIGLGRSSLSGQSLSEVFLNVKEKVLAMKPDIIRLWNFPKEIKAFTIDRDKNTIAFSGSHFRLPLLLRVSDKRVEPLPESEYSAPLRFQLADFAPRDNFVWIDRCYKMAQLWAPALALSTDWCVSQGQLGGQQTVQHVDKAQWQGKTAFKDTMIDMERYKGNVDTLKIVDNDIRYKADSFIFNVAGAPEEVKQFSGISRPESWGRWSNAQLGDEVKIEYKAPLPKKFDLVITAKAFGDNANRPIPVRVGNEEQTLVLGHDVSTITLHFNNPTDANTLVIAPPAPVSTNEGNILGHSPRKLGIGMVEIKVVNVEG
What is the function of this protein?
Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones.
What are the official names of this protein?
Phosphoglycerol transferase I, Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the OpgB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISCS2_ARCFU
Sequence: MAYFDYTSAKPVDERVLEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREKVAKLVNGGGGTVVFTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSVINPAKFLQKQGFEVEYIPVGKYGEVDVSFIDQKLRDDTILVSVQHANNEIGTIQPVEEISEVLAGKAALHIDATASVGQIEVDVEKIGADMLTISSNDIYGPKGVGALWIRKEAKLQPVILGGGQENGLRSGSENVPSIVGFGKAAEITAMEWREEAERLRRLRDRIIDNVLKIEESYLNGHPEKRLPNNVNVRFSYIEGESIVLSLDMAGIQASTGSACSSKTLQPSHVLMACGLKHEEAHGTLLLTLGRYNTDEDVDRLLEVLPGVIERLRSMSPLYRR
What is the function of this protein?
Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable).  Binds 1 2Fe-2S cluster per subunit in a crystal formed under reducing conditions; this subunit provides 1 ligand while IscU provides the other 3 ligands.  It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
What are the official names of this protein?
Cysteine desulfurase IscS 2.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVC_GEOMG
Sequence: MRVLGIDPGSRITGYGIIEKVGNRLVHVDNGAIHTDNHKEFALRLHRIFEGLCEVIAEYRPDAMAVEQVFLAHNAQSALKLGQARGAAIVAGVNAGLPVSEYTAMQVKQAVVGYGHARKEQVQQMVKSLLNLPEIAQADASDALAVAVCHANSAGMKNILRSIR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: NANK_VIBC3
Sequence: MRTLAIDIGGTKIALAIVEEGTIIQRYQIATPVVQDVTKFVQAILEKVTEWLPSIDYVGVSTTGYVTPEGITSINPETLNFPVPFPLAQTLEQLTNKPVSILNDAQAAAWFEFVQLKNPSLNMAFITVSTGVGGGIIIDGKLHKGNSGLAGHIGHMSVAIEGPLCGCGQRGCVESMASGNAIQKESEATFTETMSNVELFKQAAFNPKAEAIINRSVQAVATLCCNLKACLDLDIIVLGGGIGLAEGYLERLNKAIQSRPSVFHIPVTPAHGDYDACLLGAAFQFKE
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.
Protein: Y2850_MYCTO
Sequence: MKPYPFSAIVGHDRLRLALLLCAVRPEIGGALIRGEKGTAKSTAVRGLAALLSVATGSTETGLVELPLGATEDRVVGSLDLQRVMRDGEHAFSPGLLARAHGGVLYVDEVNLLHDHLVDILLDAAAMGRVHVERDGISHSHEARFVLIGTMNPEEGELRPQLLDRFGLTVDVQASRDIDVRVQVIRRRMAYEADPDAFVARYADADAELAHRIAAARATVDDVVLGDNELRRIAALCAAFDVDGMRADLVVARTAAAHAAWRGVRTVEEQDIRAAAELALPHRRRRDPFDDHGIDRDQLDEALALASVDPEPEPDPPGGGQSANEPASQPNSRSKSTEPGAPSSMGDDPPRPASPRLRSSPRPSAPPSKIFRTRALRVPGVGTGAPGRRSRARNASGSVVAAAEVSDPDAHGLHLFATLLAAGERAFGAGPLRPWPDDVRRAIREGREGNLVIFVVDASGSMAARDRMAAVSGATLSLLRDAYQRRDKVAVITFRQHEATLLLSPTSSAHIAGRRLARFSTGGKTPLAEGLLAARALIIREKVRDRARRPLVVVLTDGRATAGPDPLGRSRTAAAGLVAEGAAAVVVDCETSYVRLGLAAQLARQLGAPVVRLEQLHADYLVHAVRGVA
What are the official names of this protein?
Uncharacterized protein MT2916.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunits D/I family.
Protein: Y031_HELP2
Sequence: MDFSQLGGLLDGMKKEFSQLEEKNKDTIHTSKSGGGMVSVSFNGMGELVDLQIDDSLLEDKEAMQIYLMSALNDGYKAVEENRKNLAFNMLGNFAKL
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein HPP12_0031.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: UBP27_HUMAN
Sequence: MCKDYVYDKDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLGEKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEMNTQAY
What is the function of this protein?
Deubiquitinase involved in innate antiviral immunity by mediating deubiquitination of CGAS and RIGI (PubMed:31534008, PubMed:32027733).  Negatively regulates RIGI by mediating 'Lys-63'-linked deubiquitination of RIGI, inhibiting type I interferon signaling (PubMed:32027733).  Also regulates 'Lys-63'-linked ubiquitination level of MDA5/IFIH1 (PubMed:32027733).  Acts as a positive regulator of the cGAS-STING pathway by catalyzing 'Lys-48'-linked deubiquitination of CGAS, thereby promoting its stabilization (PubMed:31534008).  Can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal (By similarity).  By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 27, Deubiquitinating enzyme 27, Ubiquitin carboxyl-terminal hydrolase 22-like, Ubiquitin thioesterase 27, Ubiquitin-specific-processing protease 27, X-linked ubiquitin carboxyl-terminal hydrolase 27.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: SPY2_MACFA
Sequence: MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDGDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT
What is the function of this protein?
Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity).  Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity).  Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity).  Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity).
What are the official names of this protein?
Protein sprouty homolog 2, Spry-2.
What is the protein family that this protein belongs to?
Belongs to the sprouty family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).
Protein: SFSA_PHEZH
Sequence: MDFPSPLIRGRLVSRYKRFFADVVLDDGTPLTAHCPNPGAMLGLNTPGLTCWLSRSDDPKRKLAHTLELVEADGGLVGINTLHPNRLVAEALAAGAIPEVAGYASHRREVRYGENSRVDFLLEAPDRPRCWLEVKNVHLMRQPGLAEFPDCVAARSTRHLRELAAMAAQGDRAVVLFVVQRTDCDRFSPAADCDPKFAAALAEVASAGVEVLVYGCEIDAARVRLGRPLPWDTSGTGRPA
What are the official names of this protein?
Sugar fermentation stimulation protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: THIE_CLOBK
Sequence: MEINYELYLITDRRFLKGRQLKKVVEDAILGGVTIVQVREKDVSTREFYNIAKEVKEVTDYYKVPIIINDRLDIAQAIDASGVHLGQKDMHLNIAREILGKDKIIGISVGNVKEALEAQNNGADYLGIGTIFPTGSKKDVDAIIGIDGLSKIKDSISIPSVAIGGINKTNFKDVLKTGIEGISVISAILDEDDIKLAANNLLINK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: YCAD_ECOHS
Sequence: MSTYTQPVMLLLSGLLLLTLAIAVLNTLVPLWLAQEHMSTWQVGVVSSSYFTGNLVGTLLTGYVIKRIGFNRSYYLASFIFAAGCAGLGLMIGFWSWLAWRFVAGVGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYVGTFLGQLLVSKVSTELMSVLPWVTGLTLAGILPLLFTRVLNQQAENHDSTSITSMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLNHKGVSNASIGFWMAVLVSAGILGQWPIGRLADKFGRLLVLRVQVFVVILGSIAMLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFTAMLMQNFSDNLLFIMIASVSFIYLLMLLRNAGHTPKPVAHV
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y5G0_ENCCU
Sequence: MNTVVNISNEGKTEDLESVKRPVIYPEEEEKAEESESSIDIDALLILSTVTVWAFRLLFERALGNLFFYIVGWGNLGYLVYSTIRRLFLKSEESRDKGLDVSDIMAIMCLLLHLFMFTLLVCNSFVFSGSIGNIADVIIRNPLGILMASRNFLDSQQMMESQRAYYVSLTVVQMAFAIVLAVTFDYGNDAVAPLELLRALLLLMLVGTTFCYIEDVVIRNLKISKEKVKRFRLLAKMMLVIGCTTAGYYMMDRMFKLATTEMASTVPTPTAPRYPLASTVPPYTLLDGEYC
What are the official names of this protein?
Uncharacterized protein ECU05_1600/ECU11_0130.
What is the protein family that this protein belongs to?
To E.cuniculi ECU03_0120.