PharMolix/UniProtQA huggingface dataset:
Protein: MURC_CITBB
Sequence: MYGKIERIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSEITQRLESLGGEIFFGHAAENVANADVVVISSAVHDDNPEVVEAHLRLIPVIPRAEMLAELMRMKYGIAVAGTHGKTTTTSMVATILSKGGIDPTIVIGGRLNSLGTNARLGQGQFLVAEADESDGSFLLLSPTIAVVTNIDADHLDFYSGIEEIKDTFVEFINKIPFYGLAVLCLDNGNIADVLPRVKKRFTSYGMSAQADFRATDVKLSGFSTSFVAHHKGVRLGEITFSMPGAHNVLNALAAIAVAMELDIPFETIQEGFAGFGGVGRRFHLKGEANGIMVVDDYGHHPTEIKATLGAAKAGFAENRLVVVFQPHRYSRTKELFEEFVKAFHDADVLILTDIYPAGEAPIEGVTAEALANRVRRHGQKDVTWISDRDKLCEHLERVLAPGDILLTLGAGNVWQVGETMLLRLKAAKES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_MYCSK
Sequence: MQTHEIRKRFLDHFVKAGHTEVPSASVILDDPNLLFVNAGMVQFVPFFLGQRTPPYQRATSIQKCIRTPDIDEVGITTRHNTFFQMAGNFSFGDYFKKGAIEFAWTLLTNPVDQGGYGFDPEKLWATVYLDDDEAIQLWQEVAGLPLERIQRRGMADNYWSMGIPGPCGPSSEIYVDRGPEYGIEGGPEANEDRYIEIWNLVFMQNERGEGTGKSDFEILGPLPRKNIDTGMGIERVACLLQGVDNVYETDLLRPVIDAVAARAPRGYGRGSHSDDVRYRIIADHSRTAAILIGDGVSPGNDGRGYVLRRLLRRVIRSAKLLGIDDAVVGDLMATVRDAMGPSYPELVTDFDRIQRIAVAEETAFNRTLSSGSRLFEEAAQSTKAAGADRLSGRDAFTLHDTYGFPIELTLEMAAEADLAVDEEGFRSLMAEQRQRAKADAAARKQAHTDLTAYRELVDAHPTQFTGFDELTTEARILGIFVDGRRVPVVGHDTATAQHRIELVLDRSPFYAESGGQIADEGTITGTGASQTAKAAVSDVQKIAKTLWVHRVTVESGEFVEGDTVTAAVDPRWRHGATQGHSGTHMVHAALRQVLGPNAVQAGSLNRPGYLRFDFNWQGALTDDQRTQIEEVTNEAVEADFEVHSFTTELEKAKSMGAMALFGEAYPDEVRVVEIGGPFSLELCGGTHVRSSAQIGPVTILGESSVGSGVRRVEAYVGLDSFRHLAKERALMAGLASSLKVPSEEVPARVAGLVERLKAAEKELDRMRLANARAAAVNAVAGAERVGKVRLVAQRMAGGMSAGDLRTLVGDIRGKLGGDPAVVALIAEGDNDTVPFVVAVNPAAQDLGLRANELVKQFGAAVNGRGGGKADLAQGSGKGAAGIDAALAALRAEIDRS
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAUE_PARVE
Sequence: MQQVLQEPLIHWALRSFLAALFATAALSKLTGMEEFHGVVRNFRLLPDMASRAVAMVLPVAELAVAAGLMIPALAAPAALAAAALLGVFGLAIAVNVLRGRTQIDCGCFRNGMKQRISWAMVARNAVLTAMALGAAALLPAARPGGTADLATGMLAGSVLFLLYFSASMLGGLPARHPSTASVKGR
What is the function of this protein?
May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.
What are the official names of this protein?
Methylamine utilization protein MauE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TDRKH_DROME
Sequence: MLRNTPFGATPTYKLLLGFGLCSLGGAMLYAYFKTRNDEEEADSGGQRPASGIRGQTEEQKPQKEVCLKIVVDNEHVPLIMGRGGSNIKLIEEKTLAKIRLRDKDSGHKFCDISGVPDAVKAARALLIKEIERAPVVKVELQVPQRLASKINGRGGELLQEIRSSSLAKLNIDLNGRNGKAKITIIGNQKQVNIARKMLDDQIEEDEELVRSMEEVEQRREPRRSPTNSIASSMYSSQTSLSSHTQPRDKLMASKGEGKPMEVYVSAVASPTKFWVQLIGPQSKKLDSMVQEMTSYYSSAENRAKHVLTAPYVGQIVAAVFKFDEKWYRAEIVDIMPNQYNPKEQVIDLYFVDYGDSEYISPADICELRTDFLTLRFQAVECFLANVKSTIQTEPITWPKSSIAKFEELTEVAHWRKLIARVVTYKERPRATTAVSAAAKEGTPLPGVELFDPADNSELNIADLMITQGFALPLDDSYPVRSRSSTPSSNSDSTIEELCVSNPVTPLTPHSPMSMSIDVDSITQAENEHLAQQLQHLQHKLNGNDIKNINPAKLTATDLENGNNNNASTTNGASAH
What is the function of this protein?
Involved in the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons which is essential for germline integrity (PubMed:21447556, PubMed:29531043).  Likely to act by recruiting Piwi proteins such as AGO3 and piwi to the piRNA biogenesis machinery in the nuage (PubMed:21447556, PubMed:29531043).  Required for the final steps of primary piRNA biogenesis by participating in the 3' end-trimming of piwi-bound intermediates into mature piRNAs (PubMed:29531043).
What are the official names of this protein?
Tudor and KH domain-containing protein homolog, Partner of PIWIs protein.
What is the protein family that this protein belongs to?
Belongs to the Tdrkh family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Expressed in the cytoplasm of germline stem cells, cyst cells, nurse cells and oocytes, with strong accumulation in region IIb germline cysts in the germarium. In post-germarium egg chambers accumulates in the perinuclear loci that appear to be the nuage.
Protein: TCC3_MOUSE
Sequence: PSDKRLDADISPKPTIFLPSVAETNLHKTGTYLCILEKFFPDVIRVYWKDKNGNTILDSQEGDTLKTKGTYMKFSWLTVPERSMGKEHRCIVKHENNKGGADQEIFFPSIKKVATTCWQDKNDVLQLQFMSTSAYYTYLLLLLKSVIYLAIISFSLLRRTSVCCNEKRS
What are the official names of this protein?
T-cell receptor gamma chain C region DFL12.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PRS40_MOUSE
Sequence: MCGIRAKKSGLGGYGAGLLAALLGVSFLSQHAQTAEHVTNAANNTTIQIMKSTLSLSEVCGKTKFQGKIYGGQIAGAERWPWQASLRLYGRHICGAVLIDKNWVLSAAHCFQRSQEPSDYHVMLGYTDLNSPTRYSRTMSVQKVIVHKDYNRFHTQGSDIVLLQLRSSVEYSSHILPACVPEENIKIPKEKACWASGWGYLREDVRIPLPNELYEAELIIMSNDQCKGFFPPPVPGSGRSYYIYDDMVCAADYDMSKSICAGDSGGPLVCLLEGSWYVVGLTSWSSTCEEPIVSPSVFARVSYFDKWIKDNKKSSSNSKPGESPHHPGSPENENPEGDNKNQGAVIKPTVCTALLLSQILLQQLI
What is the function of this protein?
May play an important role in the sperm/egg interaction; released during the acrosome reaction.
What are the official names of this protein?
Serine protease 40, Testicular serine protease 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted.
Protein: ZN532_MOUSE
Sequence: MTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHIKQNAHVDDDSHTPSSSDVGVSVIVKNVRNIDSSEGVEKDGHNPTGNGLHNGFLTASSLDSYGKDGAKSLKGDTPASEVTLKDPAFSQFSPISSAEEFEDDEKIEVDDPPDKEEARAGFRSNVLTGSAPQQDFDKLKALGGENSSKTGVSTSGHTDKNKVKREAESNSITLSVYEPFKVRKAEDKLKENSEKMLESRVLDGKPSSEKSDSGIAAAASSKTKPSSKLSSCIAAIAALSAKKAASDSCKEPVANSREASPLPKEVNDSPKAADKSPESQNLIDGTKKASLKPSDSPRSVSSENSSKGSPSSPVGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQAASVMASVTSLLSSSASATVLSSPPRAPLQTAMVTSAVSSAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYTPNLSPPANAGITLPMRGYKCLECGDAFALEKSLSQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVPPSSNTAASTLQSSVGAATHTVPKVQPGIAGAVISAPASTPMSPAMPLDEDPSKLCRHSLKCLECNEVFQDEPSLATHFQHAADTSGQQMKKHPCRQCDKSFSSSHSLCRHNRIKHKGIRKVYACSHCPDSRRTFTKRLMLERHIQLMHGIKDPDVKELSDDAGDVTNDEEEEAEIKEDAKVPSPKRKLEEPVLEFRPPRGAITQPLKKLKINVFKVHKCAVCGFTTENLLQFHEHIPQHRSDGSSHQCRECGLCYTSHGSLARHLFIVHKLKEPQPVSKQNGAGEDSQQENKPSPEDEAAEGAASDRKCKVCAKTFETEAALNTHMRTHGMAFIKSKRMSSAEK
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 532.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TATA_DELAS
Sequence: MGSFSIWHWLIVLAIVVLVFGTKKLKNIGSDLGGAVKGFKDGVKDGSTSTDTPAAAPGQVAGQTAADKTTIDVEAKQKG
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HISX_BURPS
Sequence: MAIKIRKLDSTSEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFDRLNAASVAALELPQSELEAALEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGLKNDLVLAAALLGGVDRVFTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDMIAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTMPRQDVIRASLEGRGALVKVRDMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSLIEVSAEGAHTLGEIASELAYGEGLQAHAKSAEYRMKGAGDRQKG
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: ENASE_DANRE
Sequence: MIARKRKSNGSETTSGKIPKDDVSSESCLDQPADESVHEVVTFEPSTLPSVHYDPDTTEPISCSLKSLDELLSWKRNEASIFNVSSVPLASRYPPLESCPRRTLVSHDMMGGYLEDRFIQGAEVETPYAFYHWEYIDIFNYFSHQMVTIPPAVWTNAAHRHGVLSIGTFITEWTDGAKTCEAFLADEESYRAAADKLVQISHCNGFDGWLINIENELSETAVNNTGPFLRYLTDQMHERVPGSVVIWYDSVLKDGKLLWQNELNDNNRMFFDACDGFFTNYNWTEQSLEGMKSYAAAQGRFADIYVGVDVFARGKVIGGKYETNKALELIRKYDLSTAIFAPDWVYECHEKADFRQNQDKFWSLLSDFLYIHRPSSNLPFVSSFCQGFGKSLYWRGKVETERSWFNLHAQEIQPLYLSESFGNGGWLRTRGCSEDAWIGGSSLMLEGMIPSGLSDVCARIFSLHVPLAARTFVSFVFKPPVGVKVSLELKTIDGPLCTFDGTEEIASRSVFPEALAESNQLVEQFAQNCGQWASDGWATRCFLLKMIGCSLREVCIRVSRDGGDEDINFNCRIGEIMLLDADNLQAPLQSVEGICVNDVVWQTGVLKGDGHTLKVLLNATLRWQYPTRQVRHFRIHWRHLRGPDPRIPSGPLTLIGRSYSALYRVVELEVPAAPGLIELVVEPVSKEGFSVPEAQWGRQTLSYSQSPSGNPSH
What is the function of this protein?
Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core.  Involved in the processing of free oligosaccharides in the cytosol (By similarity).
What are the official names of this protein?
Cytosolic endo-beta-N-acetylglucosaminidase, ENGase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 85 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: MNMG_VIBPA
Sequence: MLYHENFDVIVVGGGHAGTEAALASARTGQKTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDAMGGLMAEAIDHAGIQFRTLNASKGPAVRATRAQADRALYKAYVRNALENAPNLTLFQQSVDDLIVEQDRVVGVVTQMGLKFHAKAVVLTVGTFLGGKIHIGMESSSGGRAGDPPSIALADRLRELPFRVDRLKTGTPPRIDARTVDFSVLEAQHGDNPTPVFSFMGKREHHPRQIPCFITHTNEQTHEVIRNNLDRSPMYAGVIEGIGPRYCPSIEDKVMRFADKNSHQIFIEPEGLTTHELYPNGISTSLPFDVQVQIVRSMKGFENAHIVRPGYAIEYDFFDPRDLKQTYETKFISGLFFAGQINGTTGYEEAAAQGLMAGLNASLYSQGKEGWSPRRDQAYMGVLIDDLSTMGTKEPYRMFTSRAEYRLLLREDNADLRLTEKARELGLIDDVRWARFNEKIENMETERQRLKSTWVNPNSAGIDELNKLLKTPMAREASGEDLLRRPEISYSQLTQLDAFAPALEDQQAAEQVEIQVKYDGYIKRQQEEIEKSLRHEHTKLPADLDYKDVKGLSNEVVAKLSEAKPESIGIASRISGITPAAISILLVHLKKHGLLKKGEEE
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NP1L1_MOUSE
Sequence: MADIDNKEQSELDQDLEDVEEVEEEETGEETKIKARQLTVQMMQNPQILAALQERLDGLVDTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEVSEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFVLEFHFEPNDYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPENGDLDDDAEAILAADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ
What is the function of this protein?
Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly.  Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair.  Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity).  Plays a key role in the regulation of embryonic neurogenesis (PubMed:29490266).  Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (PubMed:29490266).  Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (PubMed:29490266).
What are the official names of this protein?
Nucleosome assembly protein 1-like 1, Brain protein DN38, NAP-1-related protein.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Melanosome.
Protein: RUVB_ALISL
Sequence: MIEADRLIAADNPVFRDEEVIDRAIRPKKLEDYRGQDHVRSQMEIFIKAAQMRQEPLDHLLIFGPPGLGKTTLANIVANEMGVSIRTTSGPVLEKAGDLAALLTNLEENDILFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEYYKVDDLQYIVQRSADCLNLSMESEGALEVARRARGTPRIANRLLRRVRDYADVMSDSHISPDIADKALNMLDVDVCGFDYMDRKLLLAIMEKFNGGPVGLDNVAAAIGEEKDTIEDVIEPYLIQQGYLQRTPRGRIVSDRAYLHFGIDRPDK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: EX7S_ALKCK
Sequence: MAETKDLPFEEAMRQLEWLVEKLEEGNVPLEQAIDMFKEGMDLSQSCHEKLLKVEKQLDQIMHEDGELVEANLEEEANE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZRAN1_MOUSE
Sequence: MSEHGIKWACEYCTYENWPSAIKCTMCRAQRPSGTIITEDPFKSGSSDVGRDWDPSSTEGGSSPLICPDSSARPRVKSSYSMENANKWSCHMCTYLNWPRAIRCTQCLSQRRTRSPTESPQSSGSGSRPVAFSVDPCEEYNDRNKLNTRTQHWTCSVCTYENWAKAKKCVVCDHPRPNNIEAIELAETEEASSIINEQDRARWRGGCSSGNSQRRSPPTTKRDSEVKMDFQRIELAGAVGTKEELEVDFKKLKQIKNRMKKTDWLFLNACVGVVEGDLAAIEAYKSSGGDIARQLTADEVRLLNRPSAFDVGYTLVHLAIRFQRQDMLAILLTEVSQQAAKCIPAMVCPELTEQIRREIAASLHQRKGDFACYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINWSLELATRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKALHDSLHDCSHWFYTRWKDWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVAMENDGYGNRGAGANLNTDDDVTITFLPLVDSERKLLHVHFLSAQELGNEEQQEKLLREWLDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEKWLDRYRQIRPCTSLSDGEEDEDDEDE
What is the function of this protein?
Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity).  Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity).  Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (By similarity).  Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (By similarity).  Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).  Required in the stress fiber dynamics and cell migration (By similarity).
What are the official names of this protein?
Ubiquitin thioesterase Zranb1, Zinc finger Ran-binding domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C64 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm.
Protein: RL16_BACC7
Sequence: MLMPKRVKYRREHRGKMRGRAKGGTEVAFGEFGLQAQAASWITNRQIEAARRAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKIMFEIAGVSEEVAREALRLAAHKLPVKCKFVKREENGGESNEN
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: COAE_BACLD
Sequence: MTLVIGLTGGIASGKSTVAQMFQQCGITVVDADVIAKEAVEQGMPAYQKIAETFGEGVLLETGDIDRRKLGEIVFANEEKRLQLNAIVHPEVRKMMIKQRDEAIRAGERFVVLDIPLLYESGLEHLTDKVIVVWVPMELQLERLMKRNRLNKDEALNRIHAQQSLDEKKKRADAVIDNSGSLKDTEAQLHQLLDTWSNIEK
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_STAEQ
Sequence: MFMGEFDHQLDTKGRMIIPSKFRYDLNERFIITRGLDKCLFGYTLEEWQQIEEKMKTLPMTKKDARKFMRMFFSGAVEVELDKQGRINIPQNLRKYANLSKECTVIGVSNRIEIWDRETWNDFYDESEESFEDIAEDLIDFDF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ATPB_OENGL
Sequence: MRINPTTSGPGVSTLEKKKSGRIAQIIGPVLDVTFPPGKMPNIYNALVVKGRDTGGQEINVTCEVQQLLGNNRVRAVAMSATDGLTRGMEVIDTGAPLSVPVGGATLGRIFNVLGEPVDELGPVDTRTTSPIHRSAPAFIQLDTKLSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNIAKAHGGVSVFGGVGERTREGNDLYMEMKESGVINEQNIAESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDVNKQNVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLSTEMGSLQERITSTKAGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLAAKGIYPAVDPLDSTSTMLQPRIVGDEHYETAQRVKETLQRYKELQDIISILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVGLAETIRGFKLILSGELDGLPEQAFYLVGTIDEATAKAANLEMESDLKK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: DUT_VACCA
Sequence: MFNMNINSPVRFVKETNRAKSPTRQSPGAAGYDLYSAYDYTIPPGERQLIKTDISMSMPKICYGRIAPRSGLSLKGIDIGGGVIDEDYRGNIGVILINNGKCTFNVNTGDRIAQLIYQRIYYPELEEVQSLDSTNRGDQGFGSTGLR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: EIF3B_DROSE
Sequence: MAKKKSEEQSSADANDSDYQEEPNFEDPPGFVDNISDEDLLGDMLAQRPSEADGVESVVVVDNIPKVEPVRLEKLKSVINKLFSNYGDIVNVVYPVDEEGKTKGYAFMEYKQASQAEEAVKKLNNHRLDKNHTFAVNLFTDFQKYENIPEKWEPPTVQTFKVQSDLYNFINDPDTYDQYCVAAETAPNCVQVGFWQNVLPEPFELETRERFTDTFVKWSPLGTYVVTFHKPGVAIWGGSSFQKIQKFPHPGTQFVEFSPCENYLVTYGPTPTGQKIIIWDIRTGAEKRSFVADGMSVLSMFRWSHDDKFVARMGENSIHIYETPSFYLLDLKSIKIPGIRGFSWSPTDNVIAYWVEEQNQIPARVTLMEIPKKREIRNKNLFHVADCKLHWQKSGDYLCVKVDRYSKLKKDKKDLDVKFLGMFYNFEIFHMREKEIPVDSVEIRELILAFAWEPIGNKFSIIHGETNSSNVSFYEVNKGVKPSLVKRLEKKSCTHLFWSPRGQFIVMANLTMGTFEFVDSTNDYIITSSPDHFRASEVEWDPTGRYVVTGVSSWKVKEDTGFNMYTFQGRIIKRTILKNFVQFLWRPRPPTLLSEEKQKEIKKNLKKYYAAFEQKDRLRLTRASKELLEKRSQLRETFMEYRNKRIAEWADQKSRRIMLRGHVDTDNLETDEVDEEIVEFLVKEEVTLLE
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit B, eIF3b, Eukaryotic translation initiation factor 3 subunit 9.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA_ACIAC
Sequence: MTASPKQRIVVGLSGGVDSAVTAHLLKQQGHEVVGIFMKNWEDDDDSEYCSSNVDFVDAAAVADVIGIEIEHVNFAAEYKDRVFAEFLREYEAGRTPNPDVLCNAEIKFKAFLDHAMRVGAEKIATGHYARVRHNPATGLHELLKGLDPAKDQSYFLHRLNQSQLSRTLFPVGELRKTEVRRIAEEIGLPNAKKKDSTGICFIGERPFREFLNRYIQHAPGPILDDRGRRLGQHVGLSFYTLGQRQGLGIGGVKDKGAQRGGGEHAPWFVARKEVERNVLRVVQGHDHPWLLSHTLQATDANWVAGRPPAAGACAAKTRYRQQDAACTVTQAEGGDFALSFPEAQWAVTPGQSAVLYDGEVCLGGGVITAAGPVNSAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM6_BORBR
Sequence: MTAVAIPAVRDYLTDLQGRIVAALEQAGGEAFRTDAWQRAEGGGGVSRLLEGGQLFERAGVLFSHVKGTRLPPSASAHRPELAGRGWEAMGVSMVLHPRNPYVPTTHMNVRMFVAAARPGHAESDVFWFGGGLDLTPYYPFEDDARHFHRACRDALDPHGADYYPRYKQWCDEYFFLKHRNETRGIGGIFFDDLNDPGFDASFALTRSVGDSFLPAYLPIVQARRDMPYGERERDFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPLAQWRYDWQPQAGTPEAALAEFLRPREWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.