PharMolix/UniProtQA huggingface dataset:
Protein: ARGP_SALTY
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPTEQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVASKPFAERYFPNGVTRSSLLKAPAVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELESGELINLTPGLLQRRMLYWHRFAPESRMMRKVTDALLEYGHKVLRQD
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: MIAB_RALPJ
Sequence: MKKVFIKTYGCQMNEYDSDKMSDVLNAAEGLVPTDTPEDADVILFNTCSVREKAQEKVFSELGRVKALKALKPDLVVGVGGCVASQEGASIVARAPYVDVVFGPQTLHRLPDLIAARRRTGRSQVDVSFPEIEKFDHLPPARVDGASAYVSIMEGCSKYCSYCVVPYTRGEEVSRPFDDVLAEVAGLAEQGVREVTLLGQNVNAYIGKMGDTSERADFALLLEYVAEIPGIERIRYTTSHPKEFSSRLIEAYATNPKLVDHLHLPVQHGSDRILMAMKRGYTVLEYKSSIRKLRAIRPNISIATDFIVGFPGETDADFAKTMDLIHEIGYDTSFSFIYSPRPGTPAANLHDDTPQAVKLERLKHLQATIEENVARISQGMVGSVQRILVEGPSRKDPTELHGRTENNRVVNFALPDLPQVRREQLIGQMLDVRIVHAFPHSLRGEVAEERMASAAH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_BACLD
Sequence: MSHYDQQYNAIIQKIIESGISDEEYQVRTKWDSDGTPAHTLSIMSEKMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVQVLNDMGVHIWDQWRLEDGTIGAAYGYQLGKKNRTVNGQKVDQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQWYVKEGKLSLEVRARSNDMALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYEAPKLWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_VIBVU
Sequence: MANDPRNFPQRKLLVTCALPYANGSIHLGHMLEHIQADIWVRYQRLRGNIVNFICADDAHGTPIMLKAQQMGMSPEEMIAAVSIEHQKDFAGFDISFDNYHSTHSDENRELASHIYLQLKKNGFISSRTISQLFDPEKEMFLPDRFVKGTCPKCKSEDQYGDNCDACGETYSPTELINPKSAVSGATPVMKDSEHFFFDLPQFESMLKEWTRSGSLQTETANKMQEWFESGLQQWDISRDAPYFGFEIPGEKDKFFYVWLDAPIGYMGSFKNLCDKRDDLDFDEYWNKDSKTELYHFIGKDIVYFHSLFWPAMLDGSGFRKPNNVFVHGYVTVNGAKMSKSKGTFVKASTYLEHLDPECLRYYYAAKLNSRIDDLDLNLEDFTQRVNADVVNKIVNLASRNAGFIAKRFEGKLAENFVEPELYNEFVAAADRIAELYEAREFGRAIRELTALADKANQYVDEKAPWVVAKQEGKDQELQEICSVGINLFRVLMTYLKPVMPALAARTEAFLNEELTWEGVAQPLTAHEITAFKALFNRIDPKNIEAMIEASKEDAAAEMAAKEKAEASNAAQETELSKDPIAEEIEFDDFAKVDLRIAKIVSCESVPKADKLLKFQLDIGGEMRQVFSGIKAAYNPEDLVGKYTVVVANLKPRKMKFGMSEGMILAAGPGGKDLWILEPHEGAQPGMRVM
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_HALSA
Sequence: MSSLDAVVHGARELVVGPAAGGDTLETHADGAVAVVDGAVAAVGDTADVLAAYPAENATTAIDATGKTVLPGFVDPHTHALFAGDRSDEFAAKLRGKPYQEILAEGGGILRTVDAVRAASDAALVANLTAQLDVMLAHGTTTAEVKTGYGLDTETECRMLDAIAAAAAEHPVDVVTTFLGAHAVPDDTDADAYVDAVIDDQLPAAANGPARFCDVFCEADVFTVEQSRRILDAGREHGLAPKLHAEEFTRLGGAQLAADLGATSADHLLHATPEDAAALADAGVTPVLLPATAFVLDEAYADPQQFLAAADNRTGAPVALGTDLNPNCYTHSMGFVVSLACNGMRMAPADAVLAATAWAASALDRGRDGTGTLREGTDGDVLVVDAPSHVHLPYNPGVNNVEAVLTDGTVAVGGGGA
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIA_RHIFR
Sequence: MHLDRSDSNGGSSRYTLDHEPPVVPIDLKTFRREIRKFHGKEITDIADNPQEYSDFVSAKARRTADVAQQYGIRRDSENARYFSYQLGNQCVGLMRTEGGFSMEEEFESKSWRDQFPGHQEITSTVDLQVAHPLVENAGDILLEAPTSEGRRTTVAELARGKPRGESRAAMMGFVEVDDCDMVLDPKQHPDKWTQTSAAEWRRKDKPPLYLRKFEDAETAQCSTKAALTRLTKMTSCDRILARFGRDGRAPSAKTGPHVMDRERKSVTNCHALTAIPIRCLGAKELERRVSLRPS
What are the official names of this protein?
Host-inducible protein A.
What is the protein family that this protein belongs to?
Belongs to the NopP family.
Protein: PAND_NOSP7
Sequence: MQRTLLLAKIHNCTLTGANINYVGSISIDEILLEKAGILPYEQVQVVNSANGQRFITYAIPAPAHSGVIELNGGAARLGIIGDRLIIMTYGQFTPEELKNYSPTVVIVDEKNRLLEVRRYDDLLVKV
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1365_ERWT9
Sequence: MENAKQSFHDVLEFVRLFRRKNKLQREIHDNEKKIRDNQKRVLLLDNLSEYIKPGMSIEAIQEIIASMRSDYEDRVDEYIIKVADLSKERRDLSKKLKTLGEVKG
What are the official names of this protein?
UPF0265 protein ETA_13650.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: ISN1_NEUCR
Sequence: MTTRYRVEYALKTHRRDQFIEWIKALLAVPFVLYSQPHGVLEDPDRSVDTLSQTREEAHRRYSEIFRDIEAMIDDHIAHQNDAENPFPSKLKLLVPSIGPFFTRLPLEAAFKFQDNKRYISSRRFVSPSFNDIRLILNSAQIMAVTTYGTLQLATFDGDVTLYDDGQSLEPTSPVIPRLLDLLRKNVKIGIVTAAGYTTADRYYSRLHGLLDAMANSADLTPSQKQSLVVMGGEANYLFEFDSSSPHLLAPVPRQHWLTPEMAAWNEQDIAQLLDVAEAALRDCIKTLNLPATLMRKDRAVGIIPVSPEIRIPRESLEETVLLVQKILELSTVGRSRRVPFCAFNGGRDVFVDIGDKSWGVTVCQRWFSQKEGPHGVIKGENTLHVGDQFLSAGANDFRARSVGTTAWIASPVETVELLDELAELMGKKMS
What is the function of this protein?
IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.
What are the official names of this protein?
IMP-specific 5'-nucleotidase 1.
What is the protein family that this protein belongs to?
Belongs to the ISN1 family.
Protein: LDH2_STAAT
Sequence: MKTFGKKVVLIGDGSVGSSYAFAMVTQGVADEFVIIDIAKDKVKADVQDLNHGTVHSPSPVDVKAGEYEDCKDADLVVITAGAPQKPGETRLQLVEKNTKIMKSIVKSVMDSGFDGYFLIAANPVDILTRFVKEYTGLPAERVIGSGTVLDSARLQYLISQELGVAPSSVDASIIGEHGDTELAVWSQANVAGISVYDTLKEQTGSEAKAEEIYVNTRDAAYEIIQAKGSTYYGIALALMRISKAILNNENNVLNVSIQLDGQYGGHKGVYLGVPTLVNQHGAVKIYEMPLSAEEQALFDKSVKTLEDTFDSIKYLLED
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate (Potential).  Contributes to S. aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells, despite playing a secondary role in this resistance mechanism (By similarity).
What are the official names of this protein?
L-lactate dehydrogenase 2, L-LDH 2.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_STRPC
Sequence: MITQRQNDILNLIVELFTQTHEPVGSKALQRTIDSSSATIRNDMAKLEKLGLLEKAHTSSGRMPSPAGFKYFVEHSLRLDSIDEQDIYHVIKAFDFEAFKLEDMLQKASHILAEMTGYTSVILDVEPARQRLTGFDVVQLSNHDALAVMTLDESKPVTVQFAIPRNFLTRDLIAFKAIVEERLLDNSVIDIHYKLRTEIPQIVQKYFVTTDNVLQLFDYVFSELFLETVFVAGKVNSLTYSDLSTYQFLDNEQQVAISLRQSLKEGEMASVQVADSQEAALADVSVLTHKFLIPYRGFGLLSLIGPIDMDYRRSVSLVNIIGKVLAAKLGDYYRYLNSNHYEVH
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: GSPF_PSEAE
Sequence: MAAFEYLALDPSGRQQKGVLEADSARQVRQLLRERQLAPLDVKPTRTREQSGQGGRLTFARGLSARDLALVTRQLATLVQAALPIEEALRAAAAQSTSQRIQSMLLAVRAKVLEGHSLAGSLREFPTAFPELYRATVAAGEHAGHLGPVLEQLADYTEQRQQSRQKIQLALLYPVILMVASLAIVGFLLGYVVPDVVRVFIDSGQTLPLLTRVLIGVSDWVKAWGALAFVAAIGGVIGFRYALRKDAFRERWHGFLLRVPLVGRLVRSTDTARFASTLAILTRSGVPLVEALAIAAEVIANRIIRNEVVKAAQKVREGASLTRSLEATGQFPPMMLHMIASGERSGELDQMLARTARNQENDLAAQIGLMVGLFEPFMLIFMGAVVLVIVLAILLPILSLNQLVG
What is the function of this protein?
Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
What are the official names of this protein?
Type II secretion system protein F, T2SS protein F, General secretion pathway protein F.
What is the protein family that this protein belongs to?
Belongs to the GSP F family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OMPA_NEIMB
Sequence: MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSGSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF
What is the function of this protein?
Serves as a slightly cation selective porin.  Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity.
What are the official names of this protein?
Major outer membrane protein P.IA, PIA, Protein IA, Class 1 protein.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: NTA_AVIAU
Sequence: GDCHKFLGWCRGEKDPCCEHLTCHVKHGWCVWDGTI
What is the function of this protein?
Selective inhibitor of voltage-gated potassium channel Kv10. 1/KCNH1/EAG1 (IC(50)=637 nM).  It acts by shifting the voltage dependence of channel activation in a depolarising direction.  It shows a 100% inhibition at saturating concentrations, shows fast on-rates and is reversible.  It also slightly affects channel inactivation, when the membrane is highly depolarised (>+80 mV).
What are the official names of this protein?
Kappa-theraphotoxin-Aa1a, Kappa-TRTX-Aa1a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family.
What are the subcellular locations of this protein?
Secreted.
Protein: DEOC_BACCZ
Sequence: MNIAKLIDHTILKANTTKEDVMKVIEEAKEYKFASVCINPTWVKLAAEELAGHDVDVCTVIGFPLGASTTETKAFETKDAIAKGATEVDMVINVGALKDGDNELVEKDIYEVVQAAKGKALVKVIIETCLLTDEEKVRACELSVKAGADFVKTSTGFSTGGATAEDIALMRKTVGPNVGVKASGGVRTREDAEKMVAAGASRVGASASVAIVLNDAKGATDNY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_RICRS
Sequence: MLSLSKNWNTLIKPNKVAYENFPETNNKAKIVVEPLERGFGLTLGNAMRRVLLSSLQGAAITSIKIPAIEHEFSSIPGVKEDVSEVILNIKGIEVKMHVAEKRIMKLKATGPCVVTAGMIETGHDVEILNPDHVICDLAKDKQLEMELTCKVGKGYVLSTNNYEDNLPIGEIAIDALFNPVKSVTYKVENTRVGQVTDYDKLIMFVETNGAVLPEMAVGLAARILQEQLQLFISFEEQEEDKQVKTDALPFSPYLLKRVDELELSVRSANCLKNDNIIYIGDLVKRTEADMLRTPNFGRKSLNEIKEILAKFNLRFGMDVPDWPPENMQELSKRYEDSYN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RS2_HAEI8
Sequence: MAQVSMRDMINAGVHFGHQTRYWNPQMKPFIFGARNGVHIINLEKTLPLFNEALAELTRIASNNGKVLFVGTKRAASEAVQAAALDCQQYYVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRSREMEKLELSLGGIKDMGGLPDALFVIGADHEHIAVKEANNLGIPVFAIVDTNSTPAGVDFVIPGNDDATRAIQLYVSAAAAAVKEGRGNEAQVAEELAADAE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PHNC_BACC1
Sequence: MIEFRNVSKVYPNGTKGLNHINLKIQKGEFVVMVGLSGAGKSTLLRSVNRLHEITEGEIMIEGESITAAKGKGLRRMRRDIGMIFQSFNLVKRSTVLKNVLAGRVGYHSTLRTTLGIFPKEDLELAFQSLKRVNILEKAYARADELSGGQQQRVSIARALAQEAKIILADEPVASLDPLTTKQVLDDLKKINEDFGITTIVNLHSIDLARQYATRIIGLHAGEIVFDGLVEEATDEKFAEIYGDVAQKSELLEVAVK
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MINC_THEP3
Sequence: MIKEAIKIQGTKEGLVIVLEEDVDIETLKEKIVNRIEKSLKFFEGATLTVRVKSLSVKEEKLQELKDVIFEKYGIEVRIKNFQEKHIKNVTDDEIFNGLEEGITKFHKGTVRSGQVVKYHGNLVIIGDVNPGGLVQAAGNIVVMGTLRGIAHAGFTGNKEAVIVASSLRAMQLRIANVISRAPDKDDASDYPEIAVVKKGKIIVKPLYHLNDLW
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: SC23F_ARATH
Sequence: MAEMADKAKVEEMDWEGIDGVRMTWNLWPRTKVEASKCVIPLAASISPIRRHPLILDLPYAPLDCKTCKALLNAFARVDFAAMNWVCPFCYHRNHFPSHYHSISEINLPGELYPQYTTVEYTLPPDPSRVPPPPVFVFVLDTCMIEEELGYAKSALKQAIGLLPENALVGFVSFGTQAHVHELGFSEMSKVFVFKGNKEVTKDQILDQLGLGSSSRRAPTSGFSKGAQNGFQSSGVDRFLLPASECEYTLDLLLDELQSDQWPVQPGHRPQRCTGVALSVAAGLLGACLPGTGARIVALVGGPCTEGPGTIISKDLSDPVRSHKDLDKDAAPYYKKAVKFYDSIAKQLVAQGHVLDLFASALDQVGVAEMKVAVESTGGLVVLSESFGHSVFKDSFKRMFEDGEHSLGLCFNGTLEINCSKDIKIQGVIGPCSSLEKKGPNVADTVIGEGNTSAWKLCGLDKSTCLTVFFDLSSTGSTAPGALNQQLYLQFITRYQNSEGKSLARVTTLTRQWVDTAVSTENLVQGFDQETAAVVMARLTSLKMETEEGFDATRWLDRTLIRLCSKFGEYRKDDPTSFTLKPYLTLFPQFMFNLRRSQFVQVFNNSPDETAYFRMLLNRENISNAIVMIQPSLTSYSFNSGPQAALLDVASIAADKILLLDAYFSVVVFHGMTISQWRNMGYHHQPEHEAFAQLLQAPQEDSQMLVRERFPVPRLVVCDQHGSQARFLLAKLNPSATYNNANEMSAGSDIIFTDDVSLQVFIEHLQKLAVQS
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:24587212).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (PubMed:24587212).
What are the official names of this protein?
Protein transport protein SEC23 F, AtSEC23F, Protein transport protein SEC23 B, AtSEC23B, Protein transport protein SEC23 D.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
Protein: TTC27_CAEEL
Sequence: MIPADIIASIAGLVNEKDIEKITSEYQDNIWEFVESLVTHVLASNHVGYSDYNTSSFISEELARQKLSCGLNIPNAVSKSLWALHLAHEHVEKLKDLSDIPPIGYRVILEFYLVWQQLLIDPEETIRTEIEPIMEKLRVLIAEENDAFTSEDRCQIQLEMAAVRFQFYEYDKADNLIKSASEECQLNMDLSGMMGKRTRFQQRDIAQLVLIHKDPSTTGTPLPPDSDIPQSLDMNDDTLLEQVAITEQGARVDGRTLNACQLSCLLWIARHESATHRHDVLVHERCSPVLDTVIAARRYWSIQAAALLARAELERGRVRQVDRSCTQSELVVKLQQGVDDPVLIKDRLLRTSYILASGLTPFWQSSVLLAGILNSLGCTSEALLILEKLEMWDGVIDCYKQLGQMDKAETLIRRLIEQKPNDSMLHVYLGDITRNLEYFTKAIELSDDRNARAHRSLGHLLLMDKKFEEAYKHLRRSLELQPIQLGTWFNAGYCAWKLENFKESTQCYHRCVSLQPDHFEAWNNLSAAYIRHGQKPKAWKLLQEALKYNYEHPNVWENYMLLSVDVGEFSQAIQAYHRLLDMNKRGADDEVLELIAQTLLRREAEISMDESEDKAQNEAENRKEKEEMIKLLARISANHQTLSPKTLRVYALLKKPSVLSSETRTEFEKYVRLLEKSLAAANGKLTWPKEEKLALEVVETAVRLAEDRLELAKFIASDTSVKEASAKVRLSLRGILTRLDKDSGSRVSGDETEKLQEIVEVAKSLLDSVAI
What is the function of this protein?
Developmental protein required for cell fate determination in both the germline and seam cells of the developing epidermis.  Specifically, involved in sex determination and may function in parallel or downstream of other sex determination factors, including tra-2 and fem-3, to promote oogenesis in its role in the regulation of the switch from spermatogenesis to oogenesis in the gonads.  Also implicated in the mitosis to meiosis switch in distal tip cells.
What are the official names of this protein?
Tetratricopeptide repeat-containing protein trd-1, TPR repeat protein 27, Tetratricopeptide repeat regulator of differentiation protein 1.
What is the protein family that this protein belongs to?
Belongs to the TTC27 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KBX3_HETLA
Sequence: MNSKLTALIFLGLVAIASCGWINEEKIQKKIDEKIGNNILGGMAKAVVHKLAKGEFQCVANIDTMGNCETHCQKTSGEKGFCHGTKCKCGKPLSY
What is the function of this protein?
Has antibacterial activity against B. subtilis, K. pneumoniae and P. aeruginosa.
What are the official names of this protein?
Heteroscorpine-1, HS-1.
What is the protein family that this protein belongs to?
Belongs to the long chain scorpion toxin family. Class 3 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CNSB_PENEN
Sequence: MNSPTASDPIVRTLDAPETKDMQEAFLPGESPQDVASVIQETMDIFDKRMRLTHPHCFCYVPSCPSPLAWVGDLFTSLYNVNAVSWDVSSGPSAMEQGMIRWLAQQVGLPPSAGGCFVSGGSMANLSAVVAARDKLLPPMRRAEGTIYTSDQTHISIKKCLHIIGFDEHQIRVIPTDHLFRMDTDILRRTIAADRQCGRLPFLVVASCGTTNTGSIDPLHALADVAEEEGLWLHVDGAYGASIALSDKYRHLVDGIGRADSISWDGHKWLFQTYGCGIVLTRDSASLAHSFAVDAEYINSTTPHGAVNFYNLSPELSRPARAMPLWFTLRVLGRRQMGEMIDQGFLLARTAEEEIRRYPHWVILAPVTASIVVFRYCPLGLKDDDLDTLNLALSARLLAENVASILTTNIRGRVALRFCATNPATQADTITKVVQQMDQMANTMPTCGLGMCKE
What is the function of this protein?
L-tryptophan decarboxylase; part of the gene cluster that mediates the biosynthesis of communesins, a prominent class of indole alkaloids with great potential as pharmaceuticals (PubMed:25571861).  Communesins are biosynthesized by the coupling of tryptamine and aurantioclavine, two building blocks derived from L-tryptophan (PubMed:25571861).  The L-tryptophan decarboxylase cnsB converts L-tryptophan to tryptamine, whereas the tryptophan dimethylallyltransferase cnsF converts L-tryptophan to 4-dimethylallyl tryptophan which is further transformed to aurantioclavine by the aurantioclavine synthase cnsA, probably aided by the catalase cnsD (PubMed:25571861).  The cytochrome P450 monooxygenase cnsC catalyzes the heterodimeric coupling between the two different indole moieties, tryptamine and aurantioclavine, to construct vicinal quaternary stereocenters and yield the heptacyclic communesin scaffold (PubMed:26963294).  The O-methyltransferase cnsE then methylates the communesin scaffold to produce communesin K, the simplest characterized communesin that contains the heptacyclic core (PubMed:25571861).  The dioxygenase cnsJ converts communesin K into communesin I (PubMed:25571861).  Acylation to introduce the hexadienyl group at position N16 of communesin I by the acyltransferase cnsK leads to the production of communesin B.  The hexadienyl group is produced by the highly reducing polyketide synthase cnsI, before being hydrolytically removed from cnsI by the serine hydrolase cnsH, converted into hexadienyl-CoA by the CoA ligase cnsG, and then transferred to communesin I by cnsK (PubMed:25571861).  Surprisingly, cnsK may also be a promiscuous acyltransferase that can tolerate a range of acyl groups, including acetyl-, propionyl-, and butyryl-CoA, which lead to communesins A, G and H respectively (PubMed:25571861).  The roles of the alpha-ketoglutarate-dependent dioxygenases cnsM and cnsP have still to be determined (PubMed:25571861).
What are the official names of this protein?
L-tryptophan decarboxylase cnsB, Communesin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: DCN1_CRYNB
Sequence: MASIVSPLSTKDSLLVTQFRAITGTSSAEAAKYIKRYKHIEAAVDAFYNNEPAPRADPAQERKLGEIWEKFKDPSDPKLIKIDGTMELCEELDIDPGTDAVLFCLAADLGSKATGEWEKAPFVAGIASYPGNIDSLPKLKAYLPTLRKKLVSDPEYFKKVYNHAFQLARGGPQSLTRSLPLDTAIDLWTLFFPPAFNHSPSALSHLPDNSPPQFTQPEFDLWIEFMQQKNKAVSKDTWALLVDFARGIDKDFKEYDEDGAWPSMIDDFVEYVREQKRGQ
What is the function of this protein?
May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes.  Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
What are the official names of this protein?
Defective in cullin neddylation protein 1.
Protein: PA2G4_MOUSE
Sequence: MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTVENATSGETLEENGAGD
What is the function of this protein?
May play a role in a ERBB3-regulated signal transduction pathway.  Seems be involved in growth regulation.  Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG).  Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity.  Binds RNA.  Associates with 28S, 18S and 5. 8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA.  May be involved in regulation of intermediate and late steps of rRNA processing.  May be involved in ribosome assembly (By similarity).  Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).  Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES.  Regulates cell proliferation, differentiation, and survival.  Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity).
What are the official names of this protein?
Proliferation-associated protein 2G4, IRES-specific cellular trans-acting factor 45 kDa, ITAF45, Mpp1, Proliferation-associated protein 1, Protein p38-2G4.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24 family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. Nucleus, nucleolus. Note=Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.