PharMolix/UniProtQA huggingface dataset:
Protein: CYREN_MOUSE
Sequence: METLKSKTKTRVLPSWMTAPVDERKVVSVKTATRKQTAAWAQRVGAATRAPATETVYCMNEAEMVDVALGILIEGRKQEKPWEQRSLEATDKLQLSPPCSSSPGSSSEEEDSRISSLAPGLSPPRGPEASDSPCSRSPEEEKEEEDALKYVREIFFS
What is the function of this protein?
Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed:30017584).  Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (By similarity).  Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (By similarity).  Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (By similarity).  In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin (PubMed:30017584).  Also involved in immunoglobulin V(D)J recombination (PubMed:30017584, PubMed:31795137).  May also act as an indirect regulator of proteasome (By similarity).
What are the official names of this protein?
Cell cycle regulator of non-homologous end joining, Cell cycle regulator of NHEJ, Modulator of retrovirus infection homolog.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (By similarity). Localizes to DNA damage sites (PubMed:30017584).
Protein: RECA_SALPK
Sequence: MAIDENKQKALAAAMGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPVYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGDNVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYNGEKIGQGKANATTWLKENPATAKEIEKRVRELLLSNQNATPDFAVDDSEGVAETNEDF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_CALS4
Sequence: MVKVKICGLRRLEDIYYANQLQPDFIGFVFSESKRRVDLKEALEFVKRLKEGIKKVGVFVNEPVEKVMEIAEKLKLDVLQFHGDETQEYIDNFKNFTVWKAIRIRSKLDLKKTGEFKVDAFLFDSFSEKGYGGTGEAFDWNILKAYKREIPVVLSGGLKEENVEEAIKLVRPYAVDVSSGVEVGGYKDFNKMKSFIEKVRGVV
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: SYA_CLOTE
Sequence: MKNMGLNEIREAYLNFFEGKGHLRMESFSLVPKNDKSLLLINAGMAPLKPYFTGVQTPPKSRVTTCQKCIRTGDIENVGKTSRHGTFFEMLGNFSFGDYFKCEVIPWAWEFVTKSLNIPKDKLYVTIYLDDDEAYDIWTKSTDIDPSRIFRLGKEDNFWEIGQGPCGPCSEIHYQREGEKINSVEEFIKKSDDDEVIEFWNLVFTQFDKDENENYNRLAHPNIDTGMGLERMATIMQGVNSIFEVDTIKAVLDEISEIANIKYGENKEKDISLRVITDHVRSVTFMISDGILPSNEGRGYVLRRLLRRASRHGKLLGIKGNFLYKVCKVVIENSHKAYKELKEKEEYIKKIIKLEEERFAETIDGGIQILNEYVDELINKGEKVLPGDKAFKLYDTYGFPIELTKEILEEKSIDIDEGGFTKEMEAQKQRARAAREETNYMGSEDTIINKLPIELQTEFLGYSELSVEAKIIAIIKGEELVEELKQGDKGIIIVDKTPFYSEKGGQIGDTGILAGKNVKVKIQDCRNNISGKILHFVEILEGSIKLQDTVNLTVDRLRRDAIRKNHSATHLLHEALKKIVGAHIEQAGSFVDEHRLRFDFNHFSSLTKEELKNVEKLVNKKIMEVIPVNTKVMNIEEAKESGAVALFDEKYDEKVRVVSLGDFSKELCGGTHVSNSGEIGLFKIISETGVAAGVRRIEGVTGFNALKYIEEKEALLEGLCEVLKCSNKDIINKATSQIEEIKNKEKEINNLKSKLASGSQEDILKNIKEVKGIKLVSGVLKDIDGGALRDLADKLRDKIQEGLVVLASVGEGKIQFVAMATKEAVAKGAHCGKIIKEVASIAGGGGGGRPDMAQAGGKNPEKAEEAIAKVEDILSSLVK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEX7_PICPA
Sequence: MFKFQTNGFSGYAVRYSPFYDNKIAVATSANYGLVGNGRLYVLSIMDDGNIITDISYDTQDGLFGVAWSETNENHVLTSSGDGCVSLFDTTLKDYPVMKFTEHQREVFSVDWSNIDKNLFCSASWDGSVKVWSPGSNRNTSLLTLRSLASREEKTGRIEKPIPVVQPSQVPMSKTRPNIRNDNNDCVYDAKFSFHDPNIIMSCNSDSHLQLWDTRLPNPLFMDFVAHNGLEALSCDFNRYRPFVVASAGVDKLAKVWDTRMIQPNVHSRPPRALNKFMGHEFAIRKLAWSPHGPTQLLTCSYDMTVRVWNDSPSPTSRVGLLDGASQPHAPPCSKIFSAHTEFVMGCDWSLWGEPGWVVTTGWDEMVYVWNTQRLQ
What is the function of this protein?
Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal, such as 3-oxoacyl-CoA thiolase (By similarity).  Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (By similarity).  Cargo protein-binding triggers interaction with PEX20 and formation of a ternary complex composed of PEX20 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (By similarity).  PEX7 receptor is then retrotranslocated into the cytosol, where it is ubiquitinated and degraded (PubMed:25009284).
What are the official names of this protein?
Peroxisomal targeting signal 2 receptor, PTS2 receptor, Peroxin-7.
What is the protein family that this protein belongs to?
Belongs to the WD repeat peroxin-7 family.
What are the subcellular locations of this protein?
Peroxisome. Cytoplasm.
Protein: DSBD_HAEIG
Sequence: MKKLFLFFTLIFTAFAANSGLFDKKQTFLKVDDAFAFSATLSTDKSQLQAHWDIADGYYLYQDKISAELVGKSNPLSLHTQQAAELHQDPYFGEVKVFTHSIDGIFRGTFNNADDKVEITYQGCTEGFCYPPETKVLRIGDLAVSQEQIVEKTVEKNTALLSEQDRLADGLFHSKWAIFGFFVLGLGLAFTPCVLPMLPLLSAIVIGQQQRPNMMRAFSLAFLYVQGMALTYTLLGLAVAAIGLPFQIALQHPYVMIGLSILFVVLALSMFGLFTIQLPNSLQNKLNTWSQKQTSGAFGGAFAMGMIAGLVASPCTSAPLSGALLYVAQSGDLFTGAVTLYLLALGMGVPLMLITLFGNKILPKSGEWMNTVKQTFGFVMLALPVFLLSRILPEVWESRLWAGLATVFFIWFALQMSKNGFGYAIKIISFALAMVTVQPLQNWIWQTQTTTQSAVENMPVSQVKFKQIKNTEELDRTLAENPHSIAMLDLYADWCVACKEFEKLTFSDPQVQQQFQNILLLQVNMTKNSPENKALMERFNVMGLPTILFFDQQNNEIKGSRVTGFMDADAFSNWIEKLL
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LUTC_BACC1
Sequence: MTGLIQNRESFLDNIAKELGRARKTDGVKRPVWKNNVNKETLKNYSQEELLEVFKNQCTNIHTTVVETTNDRLREDIQKVIVENGGGPIMLSADERFDSYGLTSLFKEELPKQNVEVNVWDPEKKEENMRIAERANIGIAFSDYTLAESGTIVVQSHKGQGRSLHFLPTVYFAIIPRETLVPRITQAVEDMNKRVENGETVASCINFITGPSNSADIEMNLVVGVHGPLKAVYFIV
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
What are the official names of this protein?
Lactate utilization protein C.
What is the protein family that this protein belongs to?
Belongs to the LutC/YkgG family.
Protein: RECF_ALISL
Sequence: MPLSRLIINDFRNIETCDIQLSTGFNFVIGPNGSGKTSVLEAIYLLGHGRSFKSSLTGRIIRNSCDELFIHGRFTTPEQFELPIGINKQRDGTTEVKIGGESGQKLAQLAKVLPLQLIHPEGFELVTDGPKFRRAFIDWGVFHVEPAFYEAWSRVKRLTKQRNALLKTAQSYRELSYWDLELANLAEKIDQWRVDYINHISEATQQICQAFLPEYDIKLSYYRGWERETPYAELLKRNFERDKQLGYTVGGPNKADLRIKVAGTPVEDVLSRGQLKLMVCALRLAQGQHLTEATGKQCIYLIDDFASELDSHRRQLLAQYLKQTKAQVFISSITAEQIADMHDEESKMFEIEHGKIAQG
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXBDA_TAKRU
Sequence: MTTSLVLNPRWPADTVMFVYENNLDDLNKNMEGLVGSGNFAASQCRNIMAHSAAAAALGGHPSGLVHSSTGYSTVDVTATSSNDTLTSSGKQCATGPCPAATVPHQSSSAATALPYSYFGNGYYPCRMGRGSLKSCTQAAGAALSSQYMDTTVNSDEYSNHRAKEFAFYHSYPSPYQSMASYLDVSVVQTLGAGEPRHDTLLPMDSYQPWALTNGWGGQMYCSKDQGQAGHLWKSALADVVAHQHDGSPFRRGRKKRIPYTKVQLKELEKEYAANKFITKDKRRKISAATNLSERQITIWFQNRRVKEKKFVAKVKSNAP
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-B13a.
What is the protein family that this protein belongs to?
Belongs to the Abd-B homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CARB_STAAS
Sequence: MPKRNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEIADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHESGVLQDNNVQLLGTELTSIQQAEDREMFRTLMNDLNVPVPESDIVNTVEQAFKFKEQVGYPLIVRPAFTMGGTGGGICHNDEELHEIVSNGLHYSPATQCLLEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPHSFDYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPITGTSYAAFEPTLDYVISKIPRFPFDKFEKGERELGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESFDLDYIKERISHQDDERLFFIGEAIRRGTTLEEIHNMTQIDYFFLHKFQNIIDIEHQLKEHQGDLEYLKYAKDYGFSDKTIAHRFNMTEEEVYQLRMENDIKPVYKMVDTCAAEFESSTPYYYGTYETENESIVTDKEKILVLGSGPIRIGQGVEFDYATVHAVWAIQKAGYEAIIVNNNPETVSTDFSISDKLYFEPLTEEDVMNIINLEKPKGVVVQFGGQTAINLADKLAKHGVKILGTSLENLNRAEDRKEFEALLRKINVPQPQGKTATSPEEALANAAEIGYPVVVRPSYVLGGRAMEIVDNDKELENYMTQAVKASPEHPVLVDRYLTGKEIEVDAICDGETVIIPGIMEHIERAGVHSGDSIAVYPPQTLTEDELATLEDYTIKLAKGLNIIGLINIQFVIAHDGVYVLEVNPRSSRTVPFLSKITDIPMAQLAMRAIIGEKLTDMGYQEGVQPYAEGVFVKAPVFSFNKLKNVDITLGPEMKSTGEVMGKDTTLEKALFKGLTGSGVEVKDHGTVLMTVSDKDKEEVVKLAQRLNEVGYKILATSGTANKLAEYDIPAEVVGKIGGENDLLTRIQNGDVQIVINTMTKGKEVERDGFQIRRTTVENGIPCLTSLDTANALTNVIESMTFTMRQM
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: NUOD_BRUO2
Sequence: MAETQVRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLMEAKTYLQAVPYLDRLDYVAPMNQEHAYALAVERLLDIEVPKRGQLIRVLYSEIGRILNHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERACGARMHAAYFRPGGVHQDLPDQLIEDIGKWIDPFFTTLKNLDDLITPNRIFKQRNVDIGVVKLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECYSEMEFDIPVGKNGDCYDRYLIRMEEMRQSARIMRQCVDLLLGKERVGPVSNTDHKIVPPKRGEMKRSMEALIHHFKLYTEGYHVPAGEVYAAVEAPKGEFGVYLVSDGSNKPYRCKLRAPGFAHLQAMDFLCRGHMLADVSAILGSLDIVFGEVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: AZOR_CLOB8
Sequence: MNKVLYIKANAKPEGKSRTFKISDVFIDEYKQNNPDDEIITLDLYKEDIDFLRSKDLDTVFGPKNEESKNHPTLKYAYQFAEADKYVIAAPMWNLSIPAILKAYVDYISVVGIAFKYTQEGAVGLLENKKAVYIAARGGSYAETPYELDGIYLRSILGFFGIKDITTISAEKLDVQGENVDKILEEAIDKAKETAKNF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RL22_HELHP
Sequence: MSRALLKYIRLSPTKARLVARQVQGMNAEIAIASLEFTPNKAARVISKVIASAVANGGYDAQDVIILSCRVDAGPVLRRFMPRAKGRATPIRKPMAHILVEVGTQKSVQQSVQSTKAKAKGAKNIKSEDSKNSLKVTESKADSKVDAAQKASTTQEKAESKTKVAKAKVATTKSTATRKTTKKKTEGEEK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: GAG_FOAMV
Sequence: MASGSNVEEYELDVEALVVILRDRNIPRNPLHGEVIGLRLTEGWWGQIERFQMVRLILQDDDNEPLQRPRYEVIQRAVNPHTMFMISGPLAELQLAFQDLDLPEGPLRFGPLANGHYVQGDPYSSSYRPVTMAETAQMTRDELEDVLNTQSEIEIQMINLLELYEVETRALRRQLAERSSTGQGGISPGAPRSRPPVSSFSGLPSLPSIPGIHPRAPSPPRATSTPGNIPWSLGDDSPPSSSFPGPSQPRVSFHPGNPFVEEEGHRPRSQSRERRREILPAPVPSAPPMIQYIPVPPPPPIGTVIPIQHIRSVTGEPPRNPREIPIWLGRNAPAIDGVFPVTTPDLRCRIINAILGGNIGLSLTPGDCLTWDSAVATLFIRTHGTFPMHQLGNVIKGIVDQEGVATAYTLGMMLSGQNYQLVSGIIRGYLPGQAVVTALQQRLDQEIDNQTRAETFIQHLNAVYEILGLNARGQSIRASVTPQPRPSRGRGRGQNTSRPSQGPANSGRGRQRPASGQSNRGSSTQNQNQDNLNQGGYNLRPRTYQPQRYGGGRGRRWNDNTNNQESRPSDQGSQTPRPNQAGSGVRGNQSQTPRPAAGRGGRGNHNRNQRSSGAGDSRAVNTVTQSATSSTDESSSAVTAASGGDQRD
What is the function of this protein?
Involved in capsid formation and genome binding.  Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome.
What are the official names of this protein?
Gag polyprotein, Pr71Gag.
What are the subcellular locations of this protein?
[Gag protein]: Virion. Host nucleus. Host cytoplasm. Note=Nuclear at initial phase, cytoplasmic at assembly. Shortly after infection, Gag protein is targeted to centrosomes. It is then actively transported into the nucleus thanks to its nuclear localization signal. In the late phases of infection, Gag proteins assemble in the cytoplasm to form the virion's capsids. SUBCELLULAR LOCATION: [p3]: Virion.
Protein: RS13_CLOTE
Sequence: MARIAGIDLPREKRVEVGLTYIFGIGTSSAKKILKETGVNPDIRIKDLSEEEVNLLRDYINQNLKVEGDLRRDVALDIKRLKEIGSYRGIRHRRGLPVRGQKTKTNARTRKGPKKLVVSRKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: ATPA_HELMI
Sequence: MSLRPEEISAIIKQQIERYEKPLEAADSGTVIQVGDGIARIYGLEKAMAGELLEFPGQVYGMVLNLEEDNIGCVILGPYTGIKEGDTVKRTGRIVEVPVGPELIGRVVNPLGQPLDGKGPINAKQFRPIESPAPGVIKRKSVHEPLQTGLKAIDAMVPIGRGQRELIIGDRQTGKTAVAVDTIINQKGQNVICIYVAIGQKASTVAGVVKTLEEHGAMDYTIVVSATASEPAPLLYIAPYAGCAMGEYFLYKGQHALCIYDDLSKQAVAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDEHGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLESDLFFSGIRPAINAGISVSRVGGAAQIKAMKQVAGRLRLELAQYRELAAFAQFGSDLDKATQARLNRGQRLVEILKQDQYKPMVVEEQVAVIFAAVNGYLDDIAVADVLKFEEGFLKYLRTEKAEILKEIREKKALSDDLTARLKEAIGAFKKTFVA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CT112_LACTA
Sequence: MKYFVVXXALVAAFACIAESKPAESEHELAEVEEENELADLEDAVWLEDLADLSDLEETRGFFGNAWKKIKGKAEKFFRKKAAKIIAKKEGITKEEAEAKVDPMSKKQIKVYLLKHYGKKALQKASEKL
What is the function of this protein?
Insecticidal, cytolytic and antimicrobial peptide.  Forms voltage-dependent, ion-permeable channels in membranes.  At high concentration causes cell membrane lysis (By similarity).
What are the official names of this protein?
M-zodatoxin-Lt8l, M-ZDTX-Lt8l, Cytoinsectotoxin 1-12.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 06 (cytoinsectotoxin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: KV117_HUMAN
Sequence: MDMRVPAQLLGLLLLWFPGARCDIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 1-17, Ig kappa chain V-I region Gal, Ig kappa chain V-I region WEA.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: QUEF_VIBPA
Sequence: MSKYSDAKELAGLTLGKKTEYANQYDASLLQPVPRSLNRDDLELGDTLPFLGHDIWTLYELSWLNSKGLPQVAVGEVYIPATSANLIESKSFKLYLNSYNQTRFASWEEVAERLTQDLSACAGEKVLVEVNPVGHYTNQPIVTMEGECIDDQDIEINSYDFDADLLAGAAGEDQVEEVLHSHLLKSNCLITNQPDWGSVEIRYQGAKIDREKLLRYLVSFREHNEFHEQCVERIFTDLMKYCQPNKLTVFARYTRRGGLDINPYRSTEQDKPAHNHRMARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RADA_STRP6
Sequence: MAKKKATFICQECGYQSPKYLGRCPNCSAWSSFVEEVEVKEVKNARVSLAGEKSRPVKLKDVDNISYHRTQTDMSEFNRVLGGGVVPGSLILIGGDPGIGKSTLLLQVSTQLANKGTVLYVSGEESAEQIKLRSERLGDIDNEFYLYAETNMQAIRTEIENIKPDFLIIDSIQTIMSPDITGVQGSVSQVREVTAELMQLAKTNNIATFIVGHVTKEGTLAGPRMLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEIGIFEMQSGGLVEVLNPSQVFLEERLDGATGSAVVVTMEGSRPILAEVQSLVTPTVFGNARRTTTGLDFNRVSLIMAVLEKRCGLLLQNQDAYLKSAGGVKLDEPAIDLAVAVAIASSYKEKPTSPQEAFLGEIGLTGEIRRVTRIEQRINEAAKLGFTKVYAPKNALQGIDIPQGIEVVGVTTVGQVLKAVFS
What is the function of this protein?
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks.  Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster.  Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB.  Does not have RecA's homology-searching function.
What are the official names of this protein?
DNA repair protein RadA, Branch migration protein RadA.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RadA subfamily.
Protein: ETTA_ECO57
Sequence: MAQFVYTMHRVGKVVPPKRHILKNISLSFFPGAKIGVLGLNGAGKSTLLRIMAGIDKDIEGEARPQPDIKIGYLPQEPQLNPEHTVRESIEEAVSEVVNALKRLDEVYALYADPDADFDKLAAEQGRLEEIIQAHDGHNLNVQLERAADALRLPDWDAKIANLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHDFEGTVVAITHDRYFLDNVAGWILELDRGEGIPWEGNYSSWLEQKDQRLAQEASQEAARRKSIEKELEWVRQGTKGRQSKGKARLARFEELNSTEYQKRNETNELFIPPGPRLGDKVLEVSNLRKSYGDRLLIDDLSFSIPKGAIVGIIGPNGAGKSTLFRMISGQEQPDSGTITLGETVKLASVDQFRDSMDNSKTVWEEVSGGLDIMKIGNTEMPSRAYVGRFNFKGVDQGKRVGELSGGERGRLHLAKLLQVGGNMLLLDEPTNDLDIETLRALENALLEFPGCAMVISHDRWFLDRIATHILDYQDEGKVEFFEGNFTEYEEYKKRTLGADALEPKRIKYKRIAK
What is the function of this protein?
A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio.  Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation.  ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
What are the official names of this protein?
Energy-dependent translational throttle protein EttA, Translational regulatory factor EttA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associates with ribosomes and polysomes.
Protein: RS8_BACSU
Sequence: MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREGFIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLGIAIISTSQGVLTDKEARAKQAGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, BS8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: HSLU_RUEST
Sequence: MTDLTPREIVSELDRFIIGQKDAKRAVAVALRNRWRRKQLPDDLRDEVHPKNILMIGPTGVGKTEISRRLAKLARAPFIKVEATKFTEVGYVGRDVEQIVRDLVDTAIVQTREHMREDVKAKAHKAAEDRVLEAIAGTDARESTLEMFRKKLKAGELDDTVIELDIADTSNPMGGMFEIPGQPGANMGMMNLGDLFGKAMGGRTTRKKLTVAESYDVLIGEEADKLLDDETVNKAALEAVEQNGIVFLDEIDKVCARSDARGGDVSREGVQRDLLPLIEGTTVSTKHGPVKTDHILFIASGAFHIAKPSDLLPELQGRLPIRVNLRALSEEDFVRILTETDNALTRQYEALLGTEKVKVTFTKDGIHALAQIAAEVNHTVENIGARRLYTVMERVFEEMSFAAPDRSGEEIIVDEPFVTKNLGELTKSTDLSRYVL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.