PharMolix/UniProtQA huggingface dataset:
Protein: PA_I02A0
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKLETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESSDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEVGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKEDYTLDEESRARIKTRLYTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCKDVSDLKQYDSDEPERRSPASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFNLGGLYEAIEECLINDPWVLLNASWFNSFLTHALK
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: SOMA_CHICK
Sequence: MAPGSWFSPLLIAVVTLGLPQEAAATFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLTPVQYLSKVFTNNLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI
What is the function of this protein?
Growth hormone plays an important role in growth control.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CHDC_BACAH
Sequence: MSEATTTLDGWYCLHDLRSIDWAAWKTLSSDERGQAVSEFLNVVEKWNDVAAAKKGSHAMYTVVGQKADIMLMILRPTMEELNEIETELNKTTLAEYMVPAYSYVSVVELSNYLPADEDPYQNPQILARLYPELPKANHICFYPMDKRRQGDDNWYMLPMEERKKMMYSHSKIGRQYAGKVRQVISGSVGFDDFEWGVTLFADDVLQFKKLIYEMRFDEVSARYGEFGTFFVGNILPDEKVEKFLHI
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway.  The reaction occurs in a stepwise manner with a three-propionate intermediate.
What are the official names of this protein?
Coproheme decarboxylase, Coproheme III oxidative decarboxylase, Hydrogen peroxide-dependent heme synthase.
What is the protein family that this protein belongs to?
Belongs to the ChdC family. Type 1 subfamily.
Protein: MNMA_PSEA8
Sequence: MSESAPTPRRERVIVGMSGGVDSSVSALLLLQQGYQVEGLFMKNWDEDDGTEYCTAREDLADAQAVCDRIGIKLHTANFAAEYWDNVFEHFLAEYKAGRTPNPDILCNREIKFKAFLDYALMLGADLIATGHYVRRRDRDGRTELLKGLDPNKDQSYFLHAVGGEQIARSLFPVGELEKPEVRAIAEKHGLATAKKKDSTGICFIGERRFTDFLKQYLPAQPGDIETIEGKVIGRHSGLMYHTIGQRQGLGIGGLKEAGDDPWYVLGKDLQRNVLLVGQGNDHPLLFSRALLASRIYWVNPVELERPRRLRAKVRYRQSDQDCVLEKTAEGYRAVFDEPQRAVTPGQSVVFYDGDVCLGGGVIETAEAWDFGGRP
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHH_HELAN
Sequence: MTVPSTRKDLMIVNMGPHHPSMHGVLRLIVTLDGEDVIDCEPILGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITVNAPEQLGNIQVPKRASYIRVIMLELSRIASHLLWLGPFMADIGAQTPFFYIFRERELIYDLFEAATGMRMMHNFFRIGGVAADLPHGWIDKCLDFCDYFLTGIAEYQKLITRNPIFLERVEGVGIIGGEEAINWGLSGPMLRASGIEWDLRKVDHYECYDEFDWEVQWQKEGDSLARYLVRISEMTESIKIIQQALEGIPGGPYENLEIRRFDRVKDTVWNEFDYRFISKKPSPTFELSKQELYARVEAPKGELGIFLIGDKGVFPWRYKIRPPGFINLQILPQLVKRMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: RL31_BACSU
Sequence: MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYTGRQKFASADGRVDRFNKKYGLK
What is the function of this protein?
While neither of the L31 paralogs is essential, this protein seems to function as the main L31 protein.  Has a lower affinity for 70S ribosomes than the non-zinc-containing paralog L31B (ytiA); is displaced by it to varying extents, even under zinc-replete conditions.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RS12_LISIN
Sequence: MPTINQLVRKPRQSKIKKSTSPALNKGLNSFKRELTDVNSPQKRGVCTRVGTMTPKKPNSALRKYARVRLSNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVENRGQSRSKYGTKKPKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: GSA_META3
Sequence: MDNTIINLNLEKSKKLFEESQKYLVKGVNSPVRYFKPFPFFVNNAKDYYLVDVDGNKYIDYCLAYGPAVLGHANENIANAVIEQLKHGTAYGCPTEKEITLAKEIIKRMPCAEMVRFVNSGTEATMSAIRLARGITKRNKIIKFDGAYHGAHDYVLVKSGSGALTHGAPNSPGIPEDTTKHTILAPFNDKDAIVEIIKNNKDEIACIIVEPVMGNVGCIPPREDYLKFLREITEENNIILIFDEVITGFRIAKGGAQEYYGVVPDLATVGKIMGGGFPIGAIVGKKELMENFSPNGTIYQAGTFNGNPISMTAGIETLKNLDDNFYSTTSKSAKKLSDFIGETAEKHNIPHKVYTVASMFQIYFNEEEVVNYDIAKNSNTDLFMKYFYGLMENGVFIAPSQFECCFTSIKHTDDVINTTMDAIEEVFKKITR
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGK_MYCGE
Sequence: MLNFKTLQAIDFQNKTVVLRSDFNVPMINGVISDSERILAGLDTIKFLVKKNCKIVLLSHLSRIKSLEDKLNNKKSLKPVAELLQQLLPTVKVQFSCKNTGAEVKQKVQALAFGEILLLENTRYCDVNDKGEIVKLESKNDPELAKFWASLGEIFVNDAFGTAHRKHASNAGIAKYVAKSCIGFLMEKELKNLSYLIQSPQKPFVVVLGGAKVSDKLKVVENLLKLADNILIGGGMVNTFLKAKGKATANSLVEKELIDVAKQILDKDTHNKIVLAIDQVMGSEFKDQTGITLDVSDKIQEQYQSYMSLDVGSKTIALFESYLKTAKTIFWNGPLGVFEFTNFAKGTSKIGEIIAKNKTAFSVIGGGDSAAAVKQMQLSDQFSFISTGGGASLALIGGEELVGISDIQKNS
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_HELMI
Sequence: MRMSRLFAPTLREIPAEAEVISHQLLLRAGFIRRSSAGVYHYLPLGQRVLQRIMAIVREEMNAAGGQELLMPIIQPAEIWLQSGRWHVYGDELFRLKDRHQRDFCLSPTHEESITDLVKNNVSSYRDLPMLLYHITNKYRDERRPRFGLMRGREFIMKDLYSFDRDEAGLHESYMKMYQAYVNIFRRCGLTFRPVEADPGAIGGTGGSHEFMVLAESGEAEIVYCDACDYAANTEKAECKPQVTPGLPPLPVEQVATPDQKTIEEVCNFLKVAPADTIKTMVFRADDDLVMALIRGDREINEVKLKNLLGCLDLRMATEEECREVSPGGAGFLGPVGIEEIPIYADPEVMAMTRAVAGANAPGAHLIHVCPGRDFTVIATADLRLVQAGEPCPQCGAPLKKARGIEVGQVFKLGTKYSKALNCTFLDEKGQENLMVMGCYGVGVSRTMAAAIEQNHDDNGIVWPMAIAPFQVLVVPVSNKDAAQMEAAEAIYKELIAKGVDTLLDDRPERAGVKFKDADLIGIPVRITVGNKLASDGVVEVKLRRGGEQFTASREDVVAQVQALIREQMEATPVS
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_NITMU
Sequence: MTTIKVKENEPFEVAMRRFKRTIEKTGLLTELRAREFYEKPTAERKRKLAAAVKRTYKRLRSQLLPPKLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: SCTC_XANEU
Sequence: MAPACTTAHRRRAPLAAVLMLSLLPLLSPHADAAQVPWHSRTFKYVADNKDLKEVLRDLSASQSIATWISPEVTGTLSGKFETSPQEFLDDLAATYGFVWYYDGAVLRIWGANESKSATLSLGTASTKSLRDALARMRLDDPRFPVRYDEAAHVAVVSGPPGYVDTVSAIAKQVEQGARQRDATEVQVFQLHYAQAADHTTRIGGQDVQIPGMASLLRSMYGARGAPVAAIPGPGANFGRVQPIGGGSSNTFGNAAQGQGGGASGILGLPSSWFGGASSSDRVPVSPPLPGSGAAAAAGSPASVWPELSKGRRDESNPIDAGGGAELASDAPVIEADPRTNAILIRDRPERMQSYGTLIQQLDNRPKLLQIDATIIEIRDGAMQDLGVDWRFHSQHTDIQTGDGRGGQLGFNGALSGAATDGATTPVGGTLTAVLGDAGRYLMTRVSALETTNKAKIVSSPQVATLDNVEAVMDHKQQAFVRVSGYASADLYNLSAGVSLRVLPSVVPGSPNGQMRLDVRIEDGQLGSNTVDGIPVITSSEITTQAFVNEGQSLLIAGYAYDADETDLNAIPGLSKIPLVGNLFKHRQKSGTRMQRLFLLTPHVVSP
What is the function of this protein?
Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells.  Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane (By similarity).  Necessary for both basic pathogenicity and the induction of the hypersensitive response in resistant plants (PubMed:1472717).
What are the official names of this protein?
Type 3 secretion system secretin, T3SS secretin, Hypersensitivity response secretion protein HrpA1.
What is the protein family that this protein belongs to?
Belongs to the bacterial secretin family. T3SS SctC subfamily.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: QUEA_AROAE
Sequence: MSLTLDDFDYLLPPELIAQAPLAERCASRLLVLDGERLDDRGFCDLPELVQPGDLLVFNDTRVIHARLYGTKETGGHIEVLIERAIGPHEALAQVRASKSPRAGSRLRLADAFDVTVLGRVGEFFHLRFPDSHDVLDLLEHHGKLPLPPYIDRSADEHDESRYQTVYARERGSVAAPTAGLHFDQPMLAELAKKGVHGAWLTLHVGAGTFQPVRVNDLGEHRMHRERYVIPQETVAAIAATRAAGRRVIAVGTTSLRALEGAAQDGPLEAGTGETELFILPGYRFQVVDALITNFHLPKSTLLMLVSAFAGLEPMRRAYTHAVGHSYRFFSYGDAMFITHRNDAI
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_JANMA
Sequence: MRASRFFISTLKEAPSDAEIVSHKLMMRAGMIKKIGSGIYTYMPMGLRVIRKVEAIIREEMNNAHAIELLMPLVQPAELWQETGRWDKMGAELMRVKDRHGREFAIQPTSEEVVTDVVRTEIKSYRQLPINFYHIQTKFRDERRPRFGLMRGREFTMKDAYSFDRDIDGLKKSYQIMFDAYVKIFNRFGLQFRAVAADNGAIGGSGSHEFHVIADTGEDALVYCPNSDYAANMEAAEALPLSSARAAPTQALTKTATPGKAKCEDVAALLNLPLAQTVKSIVLTVEKEDKGVTSKQVWLLLLRGDHELNEVKAAKIPGIAGYRFASEAEIIEWFDTPPGYLGPINTKKPVNLVVDRTVANMHDFVCGANEVDFHFTGVNWGRDLPEAQVFDIRNVVEGDPSPDGKGTLAIQRGIEVGHVFQLGTAYSESMKATYLDENGKPQLIQMGCYGIGVTRILGAAIEQNFDDKGIIWPTALAPFEVVLCPMGYDRSEGVKAETDKLYEALQAAGVDVILDDRGERPGAMFADWELIGVPHRIVIGDRGLKEGKLEYQGRRDAAATPVALEEMLGFVQAKLAN
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_BURP1
Sequence: MEVKAIHRGARISAQKTRLVADQIRGLPVDKALNVLTFSPKKAAGIVKKVVLSAIANAEHNEGADIDELKIKSIYVDKAASLKRFTARAKGRGNRIEKQSCHITVTVGN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: PLIGB_NOTAT
Sequence: MKSLLFCCLFGTFLATGMCLECEICIGLGLECNTWTKTCDANQDTCVTFQTEVIRAPVSLSLISKSCGTSDTCHLNYVETSPHNELTVKTKRTCCTGEECKTLPPPVLGHKVNPPNGLQCPGCLGLSSKECTEHLVSCRGSENQCLSIIGKEFGLFFRALSYKGCATESLCTLFEKRFWNVLEDVEVDFKCTPALPKSSQ
What is the function of this protein?
Inhibits the enzymatic activity of all phospholipase A2 tested, binding with micromole to nanomole affinity.
What are the official names of this protein?
Phospholipase A2 inhibitor NAI, Notechis ater inhibitor, NAI, gamma-PLI.
What is the protein family that this protein belongs to?
Belongs to the CNF-like-inhibitor family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in blood plasma.
Protein: MTNA_PELTS
Sequence: MLDTMRWTGDGLLELLDQTRLPFEKSYIKCTEYTDVAEAIKRLAVRGAPAIGAAAAYGLVLAARKIRANTKKEFLTELEARARELAATRPTAVNLHWALNRMLRKMRLAEPEDAGLLCDLLLEEAQAIFREDITGNRRMARYGLELIPEGARILTHCNAGALATAGYGTALGLVRAAHEAGRRVSVYAGETRPLLQGARLTAWEMLQEGIPVTLITDSMAGYLLAKGKADLVVVGADRIAANGDVANKIGTYSLAVLAREHKIPFYVAAPVSTIDLSLASGEEIPIEERDSSEVTHLAGRPVAPEGVNVWNPAFDVTPARLITAIITDRGIVKPPYDENLRKTVEGLNRNLVIELTAEDGKSNL
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: UVRB_SHIFL
Sequence: MSKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKAMLERRDVIVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYARNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPRFTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMDELGYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDRSTPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGRGKSRPIVEPDNVPMDMLPKALQQKIHELEGLMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1621_ARCFU
Sequence: MRETVKLIEVARELPVSRKNLQMLLLLLLCGAAAYIINLADPALEPLFLALVFGIVAGNLQRDEEKKRVVERYVPFLLPIGITLYGVNINIPYLGEFHPEIVAATLISTSLIFLTVFWLSSRLKLSRQMSILLACGSGICGVSAIAIISPLIKPRKEEFSAAIMIITAVGLTGAILYPSIAHYASISPDEFAVLAGATLHQTGIVKISSQLFGVEEEALAIKGIRIAMIALVVLILSIIYSESRFYVPWYIVSFLGVALFSSTYLPGEVVQALRPLATVMFATTLAAICYTVNVGRVQRVGVKPLFASYAGWAVGVAFVLLLLGSGAL
What are the official names of this protein?
UPF0324 membrane protein AF_1621.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MTRR_HUMAN
Sequence: MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS
What is the function of this protein?
Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308).  Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable).  The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510).  Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity).  Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme (PubMed:16769880).  Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (PubMed:16769880).
What are the official names of this protein?
Methionine synthase reductase, MSR, Aquacobalamin reductase, AqCbl reductase.
Protein: DCUP_TERTT
Sequence: MTELKNDRFLRALQGQPVDVTPVWMMRQAGRYLPEYRATRARAGDFMGLCTNPQLACEVTLQPLQRYPLDAAILFSDILTVPDAMGLGLYFETGEGPKFRNPVRTAAQVEALPVVNAENELTYVLDAVKTIRHELNGAVPLIGFSGSPWTLMTYMVEGGSSKDFRRSKAMLYSEPEVARLLLDKLVASVTDYLNAQIRAGAQAVQIFDSWGGALAHDAYLEFSLKPMQQIVNGLIREHQGRQVPVILFTKGGGQWLEAMAETGVTALGLDWTTDIGNARERVGGKVALQGNMDPSVLYASTSAIRDEVGRILASYGHGSGHVFNLGHGITPEVDPVHAGAFINAVHELSAGYHQ
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECA_PSEA6
Sequence: MDDNKTRALTAALGQIEKQFGKGAIMRLGDNQAMDIEAISTGSLTIDIALGIGGLPCGRVVEIYGPESSGKTTLTLQAIAEAQKMGKTCAFVDAEHALDPIYAGKLGVNIDDLLVSQPDTGEQALEICDMLVRSGAVDVVVVDSVAALTPKAEIEGDMGDSHVGLQARLMSQALRKLTGNIKRSNTLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGAIKDGDEVVGNETRVKVVKNKVAPPFKQAEFQIMYGQGICKEAELIDLGVKQKLVEKAGAWYSYNGERIGQGKANVVKYLKEHTEMSNDIEQKLRAELLLKKTVKAEEPAKADEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPEE_PICTO
Sequence: MRLIENWFSERYSDNLQLSFRVQDQLLSVKTDYQRIDLFNTYDFGKLLSIDGTVQLTEKDEYIYHEMITMVPYYCTAKSDSALIIGGGDGGAAKRLIDLGIKRIVNVEIDQNVVEISRKYFPELADSFNNKNVELIIGDGIKYVKDTDESFDLIIIDSTDPVGPAEGLFNKSFYENARARLSDDGIIVTQSGSPYYQPEALKMATKGMLDVFSNVRTYIAFIPTYPSGLWSFTMASKSEIMQRKDNIIPGRYFNEDVLKGSFYLPEFVKNIIKSI
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_RALSO
Sequence: MAFKVFVDGQEGTTGLRLLDYLSQRDDIELLRIAEDRRKDPAERAKFLNAADVAFLCLPDVASREAVSLVDNPNTCIIDASTAFRTSDDWAYGLPELAPGQRERLRNSKRIAVPGCHASAFVLLMRPLVEAGIVPADYPITAFSLTGYSGGGKKMIADYLAADNPKLQSPRPYALALTHKHLPEMRVQSKLALPPIFTPVVGNFLKGLAVTIGLHPQHLASKVSPADIAKVFADYYQGEQFIRVAPADNVETLDNGFFDVQGANDTNRADLFVFGSDERMVVTARLDNLGKGAAGAAVQCMNVHLGVDEATSLHVEAPVKAEGPAHPVREAAPDFAT
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.