PharMolix/UniProtQA huggingface dataset:
Protein: PSTB_STAES
Sequence: MANSQVAEKEKLDAQTNNQDSVATIVTTENNKKNTIPDSEKKIVYSTQNLDLWYGENHALQNINLDILENNVTAIIGPSGCGKSTYIKALNRMVELVPSVKTAGKILYRDQNIFDAKYSKEKLRTNVGMVFQQPNPFPKSIYDNITYGPKTHGIKNKKILDEIVEKSLRGAAIWDELKDRLHTNAYGLSGGQQQRVCIARCLAIEPDVILMDEPTSALDPISTLRVEELVQELKENYSIIMVTHNMQQAARVSDKTAFFLNGYVNEYDDTDKIFSNPADKQTEDYISGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KBL_HUMAN
Sequence: MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP
What is the function of this protein?
Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA.
What are the official names of this protein?
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, AKB ligase, Aminoacetone synthase, Glycine acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus. Note=Translocates to the nucleus upon cold and osmotic stress.
Protein: PROA_SYNWW
Sequence: MDKSLEEKLMEQGKKAKAASRFLATASTTLKNEALLKTADALEAQGAEIVAANAIDLELGEKQGLTPALLERLALNESRIKDMAQGLREIAALPDPVGEVLGMWRRPNGLEVGRIRTPIGVIGIIYESRPNVTADAAGLCLKAGNAILLRGGEEALNSNRIIARIIAQSAKDCGIPEGAVQLVDSEDRQAAVYMMKMNDYLDVLIPRGGKGLKQAVLEHASVPVIMTGMGNCHVYVDALADLSKAQKIVFNAKVQRPSVCNAAETLLVNAKIAGDFLPAMIAELKGAGVEIRGCERSREIVPDILPAREEDWDEEYLDLILAVKVLDSVEDAIEHINCHGTGHSEAIISEDYSSVRRFISAVDAAAVYANASTRFTDGNVFGFGAEMGISTQKLHARGPMGLQELTTTKFIIYGDGQIR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS81_RALSO
Sequence: MNANAPVQPSLDDLLGRIVRDDVRAMGAYHVPDASGMVKLDAMENPYHLPAMLRDALGKRLAEVALNRYPVPTADALKAQLKRVMRVPAGADVLLGNGSDEIISLIAIAAAKPGATVLAPVPGFVMYAMSAQLMGLKFVGVPLRADLTLDREAMLAAMAEHQPAVIYLAYPNNPTGNLFDAADMDALLRAARGPVCQSLVVVDEAYQPFAQHSWMPRLPEFDHLLVMRTVSKLGLAGIRLGYVAGHPKWIAELDKVRPPYNVNVLTEATAAFVLDHVDVLDAQAATLRAERTRLIDALSAQPGVTVFPSAANFLLLRVPDAAGLFERLLKRRVLVKNVSKMHPLLANCLRVTVSNPEENAQFLDAFAASLQDTP
What are the official names of this protein?
Histidinol-phosphate aminotransferase 1, Imidazole acetol-phosphate transaminase 1.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: KGUA_SYMTH
Sequence: MPNKPKGLLIVVTGPSAVGKGTICRALLAETPGIRFSVSCTTRPKRPGEVDGVEYYFISKEEFERRIAAGEFLEWAEVYGNYYGTPRGYVEEVTAQGQDVILDIDRVGARAVREQYPDAVSVFVIPPSMEALRQRIAARGTESPEAVARRLAEAPEWIREGLTYDYVIVNDDLARAVAELRAIIMAEKARTVRNGAALIETLLEKGALTDE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARAK_ARATH
Sequence: MSERAKLQKKKKVTEDLLDSLLLLPPWRNFAISQSHQSIIESSSQRLPEKMRIDENEGVSASSKHLVFAYYVTGHGFGHATRVVEVVRHLIAAGHDVHVVTGAPDFVFTSEIQSPRLKIRKVLLDCGAVQADALTVDRLASLEKYVETAVVPRAEILETEVEWLHSIKADFVVSDVVPVACRAAADAGIRSVCVTNFSWDFIYAEYVMAAGYHHRSIVWQIAEDYSHCEFLIRLPGYCPMPAFRDVIDVPLVVRRLHKSRKEVRKELGIAEDVNVVILNFGGQPSGWNLKETSLPTGWLCLVCGASETLELPPNFIKLAKDAYTPDIIAASDCMLGKIGYGTVSEALSYKVPFVFVRRDYFNEEPFLRNMLEFYQCGVEMIRRDLLMGQWTPYLERAVSLKPCYEGGINGGEIAAHILQETAIGRHCASDKLSGARRLRDAIILGYQLQRVPGRDIAIPEWYSRAENELGQSAGSSPTVQANENNSLVESCIDDFDILQGDVQGLSDTCTFLKSLAMLDAIHDSEKSTEKKTVRERKAAGGLFNWEEEIFVARAPGRLDVMGGIADYSGSLVLQMPIREACHVAVQRNLPGKHRLWKHAQARQQAKGQVPTPVLQIVSYGSEISNRAPTFDMDLSDFMDGDEPISYEKARKFFAQDPAQKWAAYVAGTILVLMIELGVRFEDSISLLVSSAVPEGKGVSSSAAVEVASMSAIAAAHGLSIDPRDLAILCQKVENHIVGAPCGVMDQMTSSCGEANKLLAMICQPAEVVGLVEIPNHVRFWGIDSGIRHSVGGADYRSVRVGAYMGRKMIKSMASSILSPSASSANGGNPEELEDEGIDLLEAEASLDYLCNLSPHRYEARYADKLPDIMLGQTFIEEYADHDDPVTVIDQKRSYSVKAPARHPIYENFRVKTFKALLTSATSDEQLTALGGLLYQCHYSYSACGLGSDGTNRLVQLVQGMQHNKSNSEDGTLYGAKITGGGSGGTVCVVGRNSLRSSQQILEIQQRYKAATGYLPLIFEGSSPGAGKFGYLRIRRRISL
What is the function of this protein?
Arabinose kinase.  Involved in the salvage pathway which converts free L-arabinose to UDP-L-arabinose.  May play a role in arabinose transport.
What are the official names of this protein?
L-arabinokinase, AtISA1.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: UBAC1_CHICK
Sequence: MFVQEEKIFAGKVLRLQVCTMEGAEWLEEVPEDTTVEKLKERCLKHCVPGSLEDPKTVTHHKLIHATSEKVLTDSKTVLEENIQDRDVLLLIKKRAPPPLPKMADVSAEEKRKQEQKAPDKDAILKATANLPSRNVDRTVAQHNMRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEEDRVDEIALRQLTEMGFPESRAVKALRLNHMSVTQAMEWLIEHADDPAVDAPLPGQTPSEAAAEAGASSAEATAGPSSEAGGEEAKDELTEIFKKIRRKREFRPDPRAVIALMEMGFDEKEVVDALRVNNNQQNAACEWLLGDRKPSPEDLDKGIDTNSPLFQAILENPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQISRIFQTLNRT
What is the function of this protein?
Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase.
What are the official names of this protein?
Ubiquitin-associated domain-containing protein 1, UBA domain-containing protein 1, E3 ubiquitin-protein ligase subunit KPC2, Kip1 ubiquitination-promoting complex protein 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPNE1_HUMAN
Sequence: MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWHLVYRSEVIKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPAQAPQA
What is the function of this protein?
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885).  Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885).  Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605).  Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385).  May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145).  May function in membrane trafficking (PubMed:9430674).  Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740).  Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740).
What are the official names of this protein?
Copine-1, Chromobindin 17, Copine I.
What is the protein family that this protein belongs to?
Belongs to the copine family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385).
Protein: S35B1_RAT
Sequence: MAASRSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGPKQETFTFALTLVFIQCVINAMFAKILIQFFDTARVDRTRTWLYAACSVSYVGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPLAKYLCVLLIVAGVALFMYKPKKVVGIEEHTVGFGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTVLLGAGILFTGELWEFLSFAERYPTIIYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISSMQWVGTVLVFLGLGLDAKFGKGTKKTSH
What is the function of this protein?
ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane.  Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction.  Regulates ER energy metabolism and protein biogenesis.  Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply.  Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER.  Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established.
What are the official names of this protein?
Solute carrier family 35 member B1, ATP/ADP exchanger ER, AXER, Endoplasmic reticulum ATP/ADP translocase, UDP-galactose transporter-related protein 1, UGTrel1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS8_MYCSJ
Sequence: MTMTDPIADFLTRLRNANSAYHDEVTLPHSKIKANIAEILKSEGYISDYRTEDARVGKSLVVQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARSGVGGEVLAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: NHAB_PECAS
Sequence: MIAMPLHRALLKNFLGYAPDWYKLTIFGFLLINPLLFYFVSPFWAGWLLVVEFIFTLGMALKCYPLQPGGLLALQAILIGMTSPQQVWHEVTGNIEVLMLLVFMVAGIYFMKQLLLFVFTKLLLRIHSKPLLSLAFCMAAAFLSAFLDALTVIAVIISVAIGFYGIYHRFASQQGEDEADISDDSALNGEEHHRTLDQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWDFVDFFLRMSPVTVPVFICGILTCVLVERFKLFGYGVNLPDNVRRVLEDYDRDMTEKRTQQDKVRLLVQAVIGVWLIIALAFHLAEVGLIGLSVIIMATTFCGVTEEHAIGKAFQDAMPFTALLTVFFAIVAVIIDQQLFSPIIHYVLQSSDSAQLTQFYLFNGLLSSISDNVFVGSVYINEARNAFESGKISLPQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSSLAPLIRLSYGRMVIMALPYTIVMTLVGLLCVEFTLVPFTDFLMNNHWISLPNLTISGSHA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PGP_METHJ
Sequence: MLRGVITDIDGTLTDEKRRLSTAAIETIRKLQEGGIEVVLSSGNTSCLLKGLCKLIGTGGTFIGENGGVYRIGFQGSMQVMANRDIAVKALNLLEEYYGKKGIRLELYSHQERYSDIAFAREVPVEEVRSLLSGWPVDIMDTNFAIHIHEAGIDKGRTFHIVAEQLGIKPDEFLGIGDSENDIGMIKAAGTGCCVANAQEDVRNISDYCSSVPYGEGFVEIMRMYFPHILAR
What is the function of this protein?
Catalyzes the dephosphorylation of 2-phosphoglycolate.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the archaeal SPP-like hydrolase family.
Protein: CBP3_HORVU
Sequence: MVTTPRLVSLLLLLALCAAAAGALRLPPDASFPGAQAERLIRALNLLPKDSSSSSGRHGARVGEGNEDVAPGQLLERRVTLPGLPEGVADLGHHAGYYRLPNTHDARMFYFFFESRGKKEDPVVIWLTGGPGCSSELAVFYENGPFTIANNMSLVWNKFGWDKISNIIFVDQPTGTGFSYSSDDRDTRHDETGVSNDLYDFLQVFFKKHPEFIKNDFFITGESYAGHYIPAFASRVHQGNKKNEGTHINLKGFAIGNGLTDPAIQYKAYTDYALEMNLIQKADYERINKFIPPCEFAIKLCGTNGKASCMAAYMVCNTIFNSIMKLVGTKNYYDVRKECEGKLCYDFSNLEKFFGDKAVRQAIGVGDIEFVSCSTSVYQAMLTDWMRNLEVGIPALLEDGINVLIYAGEYDLICNWLGNSRWVHSMEWSGQKDFAKTAESSFLVDDAQAGVLKSHGALSFLKVHNAGHMVPMDQPKAALEMLRRFTQGKLKEAVPEEESSTTSFYAAM
What are the official names of this protein?
Serine carboxypeptidase 3, CP-MIII, Serine carboxypeptidase III.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the endosperm.
Protein: RK28_SPIOL
Sequence: MAASGMLISNPSNVCFRKPQFSCSLKPKATVSELGFLTSQLSGIQISPSPLFPIISKPISAPLKPSLQPVARRICPFTGKKSNKANRVSHSNHKTKRLQFVNLQYKRVWWEAGKRFVKLRLSTKALKTIEKNGLDAVAKKAGIDLRKE
What is the function of this protein?
Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.
What are the official names of this protein?
50S ribosomal protein L28, chloroplastic, CL28, Chloroplastic large ribosomal subunit protein bL28c.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PAL1A_DANRE
Sequence: MTTSHMNGYVTESDGGGGTDIVEEGVQRHREMAVDCPSELGARTLPVRRSAQLEKIRQQQEDRRRREEEGRSRQELDLNSSMRLKKLSQNPKVGIDNPTFEQMEGPGGSAGGLQSLIAPPALLELEDLLMSLKQVQHSLNDSQSQEDVELVLQLVQKPDFQKAFSIHNSVAHYMNRPSPPYPLTDHAQTLAQEVEVMVQNSSHKEGLELSSLLSTSHMQALMMAHDSVAEQEMQLEPLVPSVNASETLTQWGGETVKIVRIEKAKDIPLGATVRNDMDSVVISRIVKGGAAERSGLLHEGDEILEINGVEIRGKDVNEVFDILADMHGVLSFVLIPSAQIKSPPIKETVVHVKAHFDYDPSDDPYVPCRELGLCFQKGDILHIISQDDPNWWQAYRDGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKTGKLWCAKKTKKKRKKMQYNANKNDDFDNEEILTYEEMALYHQPANRKRPIALIGPPNCGQNELRQRLLSTEPDRFAGPVPHTTRSRRDAEANGRDYHFVSRQAFEMDSAAGKFIESGEFEKNFYGTSTDSVRQVINTGKICLLCVHTQSLKVLRSSDLKPYIIFIAPPSQERLRALLAKDNKNPKPEELRDIIEKAREMEQNYGHLFDAAIVNTDLDKSYQELLRLINKLDTEPQWVPSSWLR
What is the function of this protein?
Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity).  Also involved in adherens junction biogenesis (By similarity).  Functions in cellular patterning of the retina (PubMed:11992120).
What are the official names of this protein?
Protein PALS1, MAGUK family factor, MAGUK p55 subfamily member 5-A, Nagie oko protein, Protein associated with Lin-7 1.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein. Cell junction, tight junction. Note=Localizes to the apical region of the cell membrane, in the vicinity of junctional complexes in the neuroepithelium and the photoreceptor layer. Enriched in the areas immediately apical to the adherens junctions-associated actin bundles.
Protein: GYRA_MICLC
Sequence: MSDETTPQTPDEPVEGAPIPGTPQTGLDIEVEHYVLPEGAADKVEPVDLESEMKRSYLDYAMAVIVGRALPDVRDGLKPVHRRVLYAMYDGGYRPDRAFNKSARVVGDVMGNYHPHGDTAIYDALVRLIQDWVQRYPLALGQGNFGSPGNDGAAAQRYTETKMAPLAMEMVRDIDEDTVDMQDNYDGKQQEPVVLPARYPNLLVNGSSGIAVGMATNIPPHNMREVAAGVQWYLEHPEATREELLEALLARVHGPDFPTGAQILGRKGIEEVYRTGRGPITMRAVVNVEEIQGRTCLVVTELPYMTNPDNLAAKIAEMVRDGKISGIADMRDETSGRTGQRLVIVLKRDAVAKVVLNNLYKHTELQSNFSANMLALVDGVPRTLSLDGFVHHWVKHQIDVIVRRTAFRKRKAEERAHILRGLLKALDMLDEVIATIRRSASADVAREALKELLDIDDVQAQAILQMQLRQLAALESQKIQDEYDDLMAKIAEYNRILESPQRQREVISEELAEIVAKHGDDRRTEIMAGFDGDMSIEDLIPEEEMVVSITRGGYVKRTRIDQYRSQARGGKGVRGATLRGDDVVEHFLTVSTHHWLLFFTNFGRVYRIKTYELLEAGRDAKGQHVANLLAFQPDERIAQIQPLVDYGRAPYLVLATRGGLVKKTPLLDYDTNRTAGLIAIKLREGDELVSARVVSPDDDLILISHKGQSLRFTATDEALRPMGRATSGVTGMKFRDDDSLLTMDVVEEDGYVFTVTDGGFAKRTHVDEYRLQNRGGLGIKVAKLVDDRGELAGGLVVREDQEVLVVMASGKVVRSAVAGVPAKGRDTMGVIFAKPDKRDRIVAVTLNNEQEMEAKADAEAEAGPDVPLDADIDPTDPVAAPEDALTQDAGEGADGGEQ
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_BACLD
Sequence: MIGVIDYGMGNLYSVSKALERIDAPYFVSEHPDELKRADSYILPGVGAFRDAMEILTENGLKTFIQAAANEGKPLLGICLGMQLLFEESEEHGASEGLGLLKGKVVKLKDCDQAGNRLKVPHMGWNLLKVHRDSPLLPKAKEGFAYFVHSYYVSGIEEEALLASAEYGVCVPAVVGLGNVYGAQFHPEKSSTVGMLILERFKQFTQEQKVKK
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAN1_EMENI
Sequence: MYSSSNSFLGGANSTRPGQQPYMQQQPPFSQFGQQQPQNQQTGLAPQPTGYNPQFSALGASQLQPQATGFPPGQIQPQYTGFPGVSPQPQQTQPTGFPASPQQTQYGGFPSLGQAPQIQVTSNTNIPLRTGQQTSSEIANSFQNASVATPTPPPKASGGKIPNIRLSFITAQDQAKFEQLFKSAVGDSQAMTGDKAKELLLRSKLPGSDLSRIWVLSDTTKSGQLLFPEFALAMYLCNLRITGRDIPSVLPETIKNEVSSMVDIISFQVPDTQPEPVAKTNVPSFDAPLLENKLAPPAPQQPRPQQPSNSQLLSQLTAQPTGFPPSSGYQANVAVQGQNQGLVPQATVFPGQASSQNLQPPQMGILNNPQPTGYTGPRPPMPPMPTGFGSNLSPSQTGGLVAQPTGIPGQWGFVNAPASGLPNIEALKQQLMPQPGREGGFSAAGLSGNASIPWAITKEEKKIYDDLFRAWDGLHKGFIGGDTAIEIMGQSGLARNDLEAIWTLADPHNRGRLNMDEFAVAMHLIYRKLNGYPVPNRLPPELIPPSTRNLNDSIGTIKSMLSQDAEHRKATGAFLQPQKTGVSYLKEHSFRGGAVSPGAGRKDATLFKNNDEAAAGYRSSARRRVGNSGRTPSPAASQASEEELSVEQLKKKIRETQIMLDAVDFEDENRAEEEDALDRRDRREAESLMDRIRRVQDDIDTHPHAALRSLDTGAERRTLRRQLQAYEDQVPQIASEVRRVEREIAEAKLELFRLKDAKAHPNSALNIVGTGPGGAVTEADRIKARARARMQARAAELAGRPAPASQDDEEAATRRLEGENARVKAEREKNDSMTRDVEESVKEFARSLEDSLKEGEESSTREHERRRWEDALGVEDVIRDFIYDLNRGSRTAHIRKEEDSRGSSLEPRSRESSAHTSTAARPSPPASVGLTGASPVTHEDRVAAARERAQRRIAERMAAAGLKPQTDAIETLAQRQERERREREERVKRAEEEDAKREQERQRRIAEEQRTPSTQAAKPAGKKPPPAPPRGSRKGRTDSTGQADAKKAAEGSAKTEQLALEQALKEEQQAQEEETKRLETEAKQREDEFAREQQEQEARLRALEEQVRQGKIKKQEEKRRREEAKKAAQEQEARLARQRAELEAAKERERQLQLELEGLDESSSDEEGPVDIATPQDSTPTQSQVLPATSDPEPPAPPTPVAEPPTVPEPEQTTASSSPESSRAVSLRLSPETESKNPYFRRNVSQPTDYPPPTPPEVPQVSSTQMPDTQSTNPFHRLAQQQQPPPPPPTQPAFTGSAPLARKTRARPEADDDWSAAESDFESSDDEDDRAGGGSAKQLASILFGTMAPPRPLSAMDTQSPSSKSATPVQGSSIPPVPPIPAEIEPSSVADGASPPPPPPPPPPPPPAAAPPPLPSAESPAGIPPPPPPPMAPPAPPPPPGPPAAAPAGAPDRSALLASIQAGKGLRKVQTNDRSTSTSAGRVL
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein pan1.
What is the protein family that this protein belongs to?
Belongs to the PAN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: RSMG_SALSV
Sequence: MLNKLSRLLADAGISLTDHQKTLLVAYVDMLHKWNKAYNLTSVRDPNEMLVRHILDSIVVAPYLQGQRFIDVGTGPGLPGIPLAIVLPDAHFTLLDSLGKRVRFLRQVQHELKLENITPVQSRVEAYPSEPPFDGVISRAFASLNDMVSWCHQLPGEKGRFYALKGHLPGDEIASLPDDFSVESVEKLRVPQLEGERHLVIIKSNKV
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGFB3_PIG
Sequence: MHLQRALVVLALLNFATVSLSMSTCTTLDFDHIKRKRVEAIRGQILSKLRLTSPPDPSMLANIPTQVLDLYNSTRELLEEVHGERGDDCTQENTESEYYAKEIYKFDMIQGLEEHNDLAVCPKGITSKIFRFNVSSVEKNETNLFRAEFRVLRMPNPSSKRSEQRIELFQILQPDEHIAKQRYIDGKNLPTRGAAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIQEVMEIKFKGVDSEDDPGRGDLGRLKKKKEHSPHLILMMIPPDRLDNPGLGAQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSSVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTAKVEQLSNMVVKSCKCS
What is the function of this protein?
Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity).  Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity).  At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity).  TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity).  Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).
What are the official names of this protein?
Transforming growth factor beta-3 proprotein.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix. SUBCELLULAR LOCATION: [Transforming growth factor beta-3]: Secreted.
Protein: RECF_RICAH
Sequence: MKNIFLHSLSLANYRNFKNLELKTDNTPIILIGENGSGKTNILEAISLFYPGRGLRSAKLDDICKASEDYCIVKALLQSQLGLAEFSTHIKRNSNRRITEYNESKIANNELSKFTSMVWLTPQMEGIFTSGSSDRRKFLDRIVYNFYPKHAELVSKYEYYMHERNKILAEDIRDDNWLKIIEGKMADMSSHIANNRLKTLEFMQQAIDELENEFPKADLSIDGIVEQRILDGEENLVNFITAELYQTRSKDKLLGRTSFGVHKSDFLVKHQKKNILAKFCSTGEQKAILIAIILAEMNYVIKLTKIAPILLLDEVFVHLDDTRRQYLIEFFTTLSMQLWVTDTNLEGIENFASKAQLIKL
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.