PharMolix/UniProtQA huggingface dataset:
Protein: RL9_SYNP2
Sequence: MSKRLQVVLNQDVRKLGNNGDLVEVAPGYARNYLLPQGIASLATPGILRQVEQRREKERQRLLAELQDAEARKVALKTVGKLIIRKQVGEENQIFGTVTTQDVADAIKERAGQDVDRRGITLPEIGKTGSYEAQVKLHPEVTATVQFDVIPL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: SPD3_CAEEL
Sequence: MDQMTVEEKILEHQELEDGSSSFRWLVSSTVIAIGGATVALYISGKIDWKIPAIEAGLALTAGGTITCGYLWFKKRVKTVRKLILQMNKTRSALRKRRQIFFSISMCMPRHRHPSILRACRLTVSAIECLTEETKSLNNGTTWQDLYTDEIREIISRSTVDSQLLKIEEIQEGDNDKMDFEQVFETLISIFKLHASEYSRVVILNFLNSPVFESKKVSKFFETLGRLQELMYNLESVERLALKTETKLSRNERKMDGKMKNKSLLELGWKQQTALALEAILERLESESVTQSEVESALHKTFLVVKAEPAFPQPVKKIDVEVKNQDQKNPEVIVIEKGTGERTDIDMVFEGTPLSEADKLSASKSAVARDVLLDGSEGRCHEASLFGELKMVLEPRRTDFAKRERTALAKFYGVDEHQLEQKEDEETFEAIASGDGEDPDPYDWRKDAEMSAGIHHDANNDDFLKSLKLRRVDDDIIE
What is the function of this protein?
In the first mitotic division in embryos, required for mitotic spindle alignment and asymmetric cell division (PubMed:9649522, PubMed:17947426).  Required for motor-driven chromosome movement and homolog searching within the nucleus, and subsequently ensures homologous chromosome pairing during the prophase stage of meiosis (PubMed:23671424).
What are the official names of this protein?
Spindle defective protein 3.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion outer membrane; Multi-pass membrane protein. Note=Localizes to mitochondria throughout interphase and mitosis (PubMed:17947426, PubMed:23671424). Localizes to mitochondria in the pachytene and transition zone regions of the germ cells (PubMed:23671424).
Protein: MANC9_ECOLX
Sequence: MLLPVIMAGGTGSRLWPMSRELYPKQFLRLFGQNSMLQETITRLSGLEVHEPMVICNEEHRFLVAEQLRQLNKLSSNIILEPVGRNTAPAIALAALQATRHGDDPLMLVLAADHIINNQPVFHDAIRVAEQYADEGHLVTFGIVPNAPETGYGYIQRGVAVTDSAHTPYQVARFVEKPDRERAGAYLASGEYYWNSGMFMFRAKKYLSELAKFRPDILEACQAAVNAADNGSDFISIPHDIFCECPDESVDYAVMEKTADAVVVGLDADWSDVGSWSALWEVSPKDGQGNVLSGDAWVHNSENCYINSDEKLVAAIGVENLVIVSTKDAVLVMNRERSQDVKKAVEFLKQNQRTEYKRHREIYRPWGRCDVVVQTPRFNVNRITVKPGGAFSMQMHHHRAEHWVILAGTGQVTVNGKQFLLSENQSTFIPIGAEHCLENPGCIPLEVLEIQSGSYLGEDDIIRIKDQYGRC
What is the function of this protein?
Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides.  This enzyme participates in synthesis of the LPS O9 antigen.
What are the official names of this protein?
Mannose-1-phosphate guanylyltransferase, GDP-mannose pyrophosphorylase, GMP, GMPP.
What is the protein family that this protein belongs to?
Belongs to the mannose-6-phosphate isomerase type 2 family.
Protein: DNLJ_FRACC
Sequence: MSATAGTADESGVASAAASADERARAASLARELDEHAYRYYVLDSPTISDAEYDRLMAELAALEERHPDLRTPDSPTQKVAGSYSTLFTPVEHLERMLSLENVFDDDEFHQWAARVARESEVDAWLCELKIDGLAVDLVYEDGYLVRAATRGDGRTGEDITPNIRTLASVPVRLRGPRVPGLLEVRGEVFFPTAKFAELNAGLVAVGGKPFANPRNAAAGSLRQKDPRVTATRPLEMIVHGLGAQRGFEVTSQSAAYARFAELGLPVATHFEVLATVPGVLDYVHRWGDARHDVVHEIDGVVVKVDSFALQRRLGSTSKSPRWAVAYKYPPEEVTTKLRDIRVNVGRTGRVTPFGELEPVLVAGSTVGLATLHNIDEVGRKGVLIGDTVVLRKAGDVIPEIVGPVVDLREGSERAFVMPTRCPECGTELVRPEGEVDIRCPNTVSCPAQLRESIFHFASRGAMDIDGLGYETATALLEAGRVRDIGDIFHLTPESFEGLRGFAQKKIDQILRGVEAARHRPLWRLLVGLSIRHVGPTAARALARELRSLEAIAATSAEDLAAVEGVGPKIAGAVLDWFADERHRDILARIAAGGARLADVGAEEGPRPLDGVTVVITGTLTDWSRDSAKEAVEARGGKVTGSVSRKTTAVVVGADPGASKYDKARSLRIPMLDEAGFAVLLAQGVDAASKLAVPADGPEKAETPVE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: HSLO_GLOC7
Sequence: MADQLIRATAADGGIRAVGVISTRLTEEARVRHKLSYVATAALGRAMTSGLLLASSMKREGSRVNIRIKGDGPLGGLLVDAGLDGTVRGYVGNPSVELPPNAKGKLDVGGAVGRDGYLYVVRDVGYGYPYSSTVELVSGEVGDDVAHYLITSEQTPSALLVGVFVDVTGVIASGGILLQVMPKAARDEELVSTLESRVGQLTGFTPLLRAGKTLPEIFEQLLGDLGLVILPEIQMVRFDCHCSFERVLGALKMLGEAELQDMIEKDDGAEATCQFCGEVYQASREHLTQLIEDLRAQSG
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL144_MIMIV
Sequence: MQSYVICVNNQCNVYLANNTKQLFDYILTNIDEFRKLFKFMRFTNSPIKKYLSDFYEICLKDSHTNLFDKSEWISTKEKLIERLKLIGYSSFFKRINGIDTDLFSSTNTLGTIRFYKANKTIDADSDYDSNNASENNFDNNDDDDDCYYTNKSLTNENQNEDQDENQNEITEEIDNPINRLLEQKISNGQKMTNSQFMCKMIDIFDSDRTYKNFDLISKLGGKLWILHENIHE
What are the official names of this protein?
Uncharacterized protein L144.
Protein: SYS_PSEPK
Sequence: MLDSKLLRGQLQEVADRLASRGFSLDVARIESLEERRKAVQTRTEQLQAERNARSKSIGQAKAKGEDIAPLMADVERMANELAAGKAELDAIQAELDGILLTIPNLPDASVPVGASEDDNVEVRRWGTPKAFDFEIKDHVALGEISGGLDFEAAAKLSGARFAVLRGPVARLHRALAQFMINLHTGEHGYEEHYTPYMVQAPALQGTGQLPKFEEDLFKITREGEADFYLIPTAEVSLTNLVAGEILDAKQLPLKLVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQVVEPSKSMEALEGLTANAERVLQLLELPYRVLALCTGDMGFGAVKTYDLEVWVPSQDKYREISSCSNCGDFQARRMQARWRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSILVPEVLKPYMGGVEVIR
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARCC_BACLD
Sequence: MKKRKIVVALGGNAIQTGDASAEAQKRALEETAMYLADMIDSGAELIITHGNGPQVGNLMIQQKEADSPKTPAMPLETCVSMTQGMIGYWLQNALDRALHAKGKGGHAATVITRVAVRSDDEAFRNPTKPIGPFYSEEEAKELMNSRNGGLVFKEDAGRGWRRVVPSPAPVSILEHDVINDLVEHGHIVIAAGGGGVPVIENGDAVSGIDAVIDKDFAACKLAELVQADELVILTGVDYVAVDYLKPTERALKRVTTEELKGYIKEKQFAEGSMLPKVKAAIQFAEAKKGNKTVITSLKLAKDALQGNAGTIVVQA
What are the official names of this protein?
Carbamate kinase.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSF_ARATH
Sequence: MAGRYGSQVMTMTVTNTPSADLAFTNLAYCSSSDLRQFSVPGSDLFLANVADSFILSLCGHGSIRDGNIALNAIQRRHARVSTGDMVSVSRFVPPENFDLAMLTLELEFVKKGTKSEQVDAALLSTQLKRKYTNQVLTVGQKATFEYHGTNYILTVNRADVEGQDHTNGIERGLLSKDTYIVFEASNASGIKIVNQREAASSNIFKHKEFNLESLGIGGLGAEFADIFRRAFASRVFPPHVTSRLGIKHVKGMLLFGPPGTGKTLMARQIGKMLNGKDPKIVNGPEVLSKFVGETEKNVRDLFADAEQDQRTLGDASELHVIIFDEIDAICKSRGSTRDGTGVHDSIVNQLLTKIDGVEALNNVLLIGMTNRKDLLDEALLRPGRLEVQVEISLPDEAGRLQILQIHTNKMKENSFLGTDINLQELAARTKNYSGAELEGVVKSATSYALNRQLSMDDLTKPVEEENIKITMEDFLHAIYEVQPAFGASTDDLERCRLNGMVDCGHRHNHIYKRAMLLVEQVKVSTRSPLVTCLLEGPSGSGKTALAATIGIDSDFPYVKIVSAETMIGLSESTKCAHIVKVFEDAYKSPMSIIILDDIERLLEFIAIGPRFSNIISQTLMVLLKRLPPKGKKLLVFGTTSEVTFLESVGISDCFSVTHSVPTLQKEDAKKVLNQLNLFSEDDVDSAAEALNDMPIKKIYMLIEMAAQGENGGSAEAIYAGREKININHFYDCLGDFIRFTG
What is the function of this protein?
Required for vesicle-mediated transport.  Catalyzes the fusion of transport vesicles within the Golgi cisternae.  Is also required for transport from the endoplasmic reticulum to the Golgi stack.  Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity).  Required for maintaining the normal morphology of the Golgi apparatus (PubMed:29398689).
What are the official names of this protein?
Vesicle-fusing ATPase, N-ethylmaleimide-sensitive fusion protein, Vesicular-fusion protein NSF.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_DEIDV
Sequence: MSERKYFGTDGVRAVAGEFPLTSAWVMSLGAAAGEVLRRVNPHARVVIGKDTRQSGDMLEAALAAGLTSRGVTVIHVGVLPTPGVSYLTRHLKADAGVVISASHNPYEDNGIKFFGADGQKLSDATELQIEAAIDEVPGFAPLTGTAMGSVTNYTEAEHLYTDFLKSHAPDLSGLKIALDCANGAAYRVAPKVFQAAGADVFAIYTTPDGRNINRGCGSTHMDHLRQIVREGEYDLGVAFDGDADRALFVDSRGQVVHGDHMLLLNARARGEQAVVATIMTNMALEAKLQDAGIPLERTAVGDRYVHERLHEKGLSLGGEQSGHVLFLDISPTGDGVLTALLTLASMKKLGTTLDALHDDLVMYPQTLVNVRVQDKKAIAVDQQVQQAVRQAEEQLLGRGRVNLRPSGTENLIRVMVEGQDAAEIHEVARVLAGVVEARGQA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: TYRT_STRLN
Sequence: MPRLTRRRALTAAAALASGAGAGAGAQAAAAPGAAAHDHGSPDVPLPCSLLDLLPLLPLLLDEVIKGRGIQGGPHRGGGHHHGTGYAVFLDGVELHVMRNADGSWISVVSHYDPVPTPRAAARAAVDELQGAKLVPFPAN
What is the function of this protein?
This protein may function to deliver copper to tyrosinase.
What are the official names of this protein?
Tyrosinase cofactor.
What is the protein family that this protein belongs to?
Belongs to the melC1 family.
Protein: Y3630_HAEIE
Sequence: MKLRAVVLGLATLCTSTATFAGMVSTSSNLEFLAIDGQKASKSLGKAKTFTVDDTQNHQVVVRLNEIVGSGSNQSLFESNPVIVTFQGNAEDLVISAPVIRNLDSGDKFNQMPNITVKTKSGNAISAKVDVLKQEGLFPSGNVLNDLAEYNASGAAASVSKFAATTVASSVAVAPAGNAKANKGKVVVQGENVAEQQLQYWFQQADKETQTRFLNWAKSHK
What are the official names of this protein?
UPF0319 protein CGSHiEE_03630.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: TWF_DICDI
Sequence: MSHSSGIPASQELISAFGSANTGDVRLIKVVIKNDELVVDQKLNVQSDFETDLELAHSVLQKDSPCYILYKKDDKSIELTGYNWIFMFFVPDNAKVREKMTYAATRGNLKRELGASHFVDEIYSSNMNDFSKKGYQQHKLHQESEAPLTMEEQQRNDEKEQGLFVGGGGSGMHVHGISFPVDSDASTAVSNFINKKFNYIELSVNVDDEKIIFSSSSNIDIEAISSKISSTEPSFHFFRYSHQHEGENLDSIIYIYSCPDGSNGTKSAPVRKRMLFSSSKANVEQLVTSHNVKIDLKLEINSPSEISEESIINELHPPKVEEKKAFSKPSRPGRK
What is the function of this protein?
Actin-binding protein involved in motile and morphological processes.  Inhibits actin polymerization, likely by sequestering G-actin (By similarity).
What are the official names of this protein?
Twinfilin.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Protein: NCKX5_DANRE
Sequence: MRTDVFLQRRKRRDVLLSIIALLLLIFAIVHLVFCAGLSFQGSSSARVRRDLENASECVQPQSSEFPEGFFTVQERKDGGILIYFMIIFYMLLSVSIVCDEYFLPSLEVISERLGLSQDVAGATFMAAGSSAPELVTAFLGVFVTKGDIGVSTIMGSAVYNLLCICAACGLLSSAVGRLSCWPLFRDCVAYAISVAAVIAIISDNRVYWYDGACLLLVYGVYVAVLCFDLRISEYVMQRFSPCCWCLKPRDRDSGEQQPLVGWSDDSSLRVQRRSRNDSGIFQDDSGYSHLSLSLHGLNEISDEHKSVFSMPDHDLKRILWVLSLPVSTLLFVSVPDCRRPFWKNFYMLTFLMSAVWISAFTYVLVWMVTIVGETLGIPDTVMGMTLLAAGTSIPDTVASVMVAREGKSDMAMSNIVGSNVFDMLCLGLPWFIQTVFVDVGSPVEVNSSGLVFMSCTLLLSIIFLFLAVHINGWKLDWKLGLVCLACYILFATLSILYELGIIGNNPIRSCSD
What is the function of this protein?
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (By similarity).  Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253).  Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253).
What are the official names of this protein?
Sodium/potassium/calcium exchanger 5, Na(+)/K(+)/Ca(2+)-exchange protein 5, Protein golden, Solute carrier family 24 member 5.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Melanosome. Note=Enriched in late-stage melanosomes.
Protein: HES4_XENTR
Sequence: MPADSMEKPTASPIAGAPASSAQTPDKPKSASEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMTAALTADPSVLGKYRAGFNECMNEVTRFLSTCEGVNTEVRTRLLGHLSSCLGQIVAMNYQQPPSSQQPLHVQLPSSTPAPVPMPCKVNPAEAISPKVFQGGFQLVPATDGQFAFLIPNPAYTTSPGPVIPLYANTNVTSPGGPQSQSPVQGLTTFGHKMPHMAQAVSPLGGSTGADSAESVWRPW
What is the function of this protein?
Transcriptional repressor.  Binds DNA on N-box motifs: 5'-CACNAG-3'.  Promotes floor plate development and prechordal plate development.  Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1).  Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms.  Also acts via repressor-dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression.  Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation).  Inhibits myogenesis (By similarity).
What are the official names of this protein?
Transcription factor HES-4, Hairy and enhancer of split 4, Protein hairy-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBI_CYCTA
Sequence: MFTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGRKE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FOLD_LISMC
Sequence: MGEIIDGKKLAKEIQEKVTREVAELVKEGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSVVEELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRAVVIGRSNIVGKPVAQLLLNENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAVVIDVGMDRDENNKLCGDVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAKRIWKMN
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RS5_DESPS
Sequence: MSDFKRSKANNNTEELIEKIVFINRVAKVVKGGRRFSFSAIVVVGDGNGKVGYGLGKANQVPEAIRKGVERARKDMALVSLTDVSIPHQVIGHYGAGRVFLRPASAGTGLIAGGPVRAVLEAAGVSNILTKCLGSHNPHNMVKATIDGLKQLRSAQKIAELRGKNVEEITA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: Y444_STAAM
Sequence: MKSIKRIGLCISLLILIIFATSCGSNKITGDSKEEQIKKSFAKSLDKYPTENLEEFYDKEGYRDGEFEKDDKGTWLIRSEMKIQLKGENLESRGAVIEINRNTRTAKGNYIVREVVEDSDGMTHNHTKRYPVKMENNKMIPLKSIDDEKVKKEIEEFKFFVQYGNFKELENYKEDEVSYNPEVPIYSAQYQLKNSDYNVEQLRKRYNIPTQKAPKLLLKGSGNLKGSSVGYKNIEFTFVENKEENIYFTDSVYFNPSEDK
What are the official names of this protein?
Uncharacterized lipoprotein SAV0444.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: AZOR_AZOBR
Sequence: MKILRIDSSPLGDASVSRQLTASIVAALRQATPDAEVSVRDLTVAPPDHLTGELMQVVKFRNLEGLTARQQEELALTDALVDEFLAADVVVIGAPMYNFTVPTQLKAWIDRIAQAGRTFRYTETGPVGLAGGKKVYIASTRGGVYSTNAAMSALDHQEAFLRTVLGFLGVTDVTVIRAEGVGMGPDARAKALAAAQQEIDALAVPVAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: UBIE_LEGPC
Sequence: MANQKQTTHFGFKSVDWNEKEKKVAEVFHSVAKNYDRMNDLMSLGIHHLWKRYTIELSHVRPGQSVLDLAGGSGDLTRLLSQKVGNSGQVILADINAAMLHVGRDRLLDEGLFKNIRYVQGNAQCLPFADNSFHCITMGFGLRNVTDKDEALQSMYRVCKPGGKLMVLEFSTPVFPGLKPVYDWYSFNILPKIGKFVANDEASYQYLAESIRMHPDQETLKAMIERVGFEDCHYHNLSGGIVALHIAYKY
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: ACT_SCHDU
Sequence: MADGDGEVSALVCDNGSGMVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGVVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLDLAGRDLTDNLMTILMERGYNFTTTAEREIVRDIKEKLCYVALDYEQEMANSLTSSQNEKNYELPDGQQITVGNERFRCPEVLFQPGLLGQESVGVHETTFNSIMKCDVDIRKDLYNNIVLSGGTTMFPGIADRMSKEITAVAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWIAKAEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: OTNI_PECAS
Sequence: MPKFAANLSMLFTDVPFLDRFKAAADAGFTSVEYLFPYEYPAPLLAEKLRENGLKQVLFNTAPGNIAAGEWGVSALPDRIEDARRDIDNALEYALALNCPSVLVMGGVVPPGEDRDAYQQTFIDNLRYAADKFAPHGINIMIEALSAKVKPNYLFASQYQALELANLIDRPNIYIQVDFFHAQIVDGNLTQIIHDLDGRIGHIQIASVPARHEPDEGEINYPFIFAELDRVNYSGWIGCEYNPRGKTEDGLGWAEPWLEKKH
What is the function of this protein?
Catalyzes the isomerization of 2-oxo-tetronate to 3-oxo-tetronate.
What are the official names of this protein?
2-oxo-tetronate isomerase, 2-dehydrotetronate isomerase.
What is the protein family that this protein belongs to?
Belongs to the hyi family. OtnI subfamily.
Protein: MGRB_SALEP
Sequence: MKKFRWVVLGIVVVVCLLLWAQVFNIMCDQDVQFFSGICAINKFIPW
What is the function of this protein?
PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing.  MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.  Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.
What are the official names of this protein?
PhoP/PhoQ regulator MgrB.
What is the protein family that this protein belongs to?
Belongs to the MgrB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: CCPR2_DEBHA
Sequence: MTAIQKPVVAKREAPKAEVNPTVSRSTQTETIKPTKERTVSVFSPPVFNFAANSFAQSVSNEYKHASPKRIKLDNSRVQVPSIVKPKQDKPRPPAIVTKPRVINIEFPNKQKSGFKLLIRPKHEPSIKKQKQGIEVLSTSNTKRITKSISVDDVEYVEKVKHAIKQVLPKPDYDDGSLGPVILRLAWHCCATYNKFTGNGGSNGSTMRFVPEITDDGNSGLDIARSALEPIKQKFPDITYSDLWTLAGKISIQEMGGPKIPWRCGRVDCIDDRYVPPNGRLPFAYKNANHIRETFGRMGFNDRETVSLLGAHGLGRCHKRFSGWEGKWTENPTSFSNDFYKVLLDEEWSLGTVPETGKEQYYNKDKSLIMLNTDIELIRDPHFLHFVKLYSQHQATFFQDFANAFGKLLELGIERDSNGNVLPKNEFY
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Putative heme-binding peroxidase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
Protein: PYRB_GEOKA
Sequence: MTHLFALSELPLDEIHRLLDEAEAFRSGRIWRPAAPMYVANLFFEPSTRTKCSFEMAERKLGLHVIPFDPERSSVQKGETLYDTVRTLEAIGVDAVVIRHHEDAYFEALRHAVGIPIINAGDGCGHHPTQSLLDLLTIRQEFGAFTGLTVAIIGDIRHSRVARSNAEVLTRLGANVLFSGPAEWKDETNPYGTYVEVDEAIARADVVMLLRIQHERHAETMGLTKEEYHARYGLTLERARRMKSGAIILHPAPVNRGVEIASELVEAKASRIFKQMENGVYVRMAVLKRAMEGRMEHGRMAEKWHVVQ
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: HCHA_ECOLI
Sequence: MTVQTSKNPQVDIAEDNAFFPSEYSLSQYTSPVSDLDGVDYPKPYRGKHKILVIAADERYLPTDNGKLFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMPFFEQHKSLFRNPKKLADVVASLNADSEYAAIFVPGGHGALIGLPESQDVAAALQWAIKNDRFVISLCHGPAAFLALRHGDNPLNGYSICAFPDAADKQTPEIGYMPGHLTWYFGEELKKMGMNIINDDITGRVHKDRKLLTGDSPFAANALGKLAAQEMLAAYAG
What is the function of this protein?
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:26102038, PubMed:26774339, PubMed:28596309).  Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.  Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals.  Is able to repair glycated serum albumin, aspartate aminotransferase, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase.  Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:26102038, PubMed:26774339).  Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA.  Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309).  Has been reported to display chaperone, peptidase and glutathione-independent glyoxalase activities (PubMed:12235139, PubMed:12565879, PubMed:14731284, PubMed:15550391, PubMed:7848303, PubMed:21696459).  However, these apparently disparate activities are all recruited to execute its protein deglycase primary function (PubMed:26102038, PubMed:26774339).  Plays an important role in protecting cells from carbonyl stress, severe heat shock and starvation, as well as in acid resistance of stationary-phase cells (PubMed:12235139, PubMed:16796689, PubMed:17158627).
What are the official names of this protein?
Protein/nucleic acid deglycase 1, Glyoxalase III, Holding molecular chaperone, Hsp31, Maillard deglycase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C56 family. HchA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.