Protein: CE290_DROME
Sequence: MSMDIPETVSLRKFRDFSARQKQELYETLLELAESIDELPKKSLRKTLELTLAVLEYKGEQVQQLQESAAGGLSSDRRLQDENEKLKRMLQKLEDERDGLKSKAKELGEEIRQLELRLQEAAQQAEISDKDSSDPLSELDKQEQLLQNIDSKNKHIKRLLKEIETLQNQNIAQSKTIVLHERELQTIKANLVQLSQDITKVEQERKSLKQKEQQQALEITRLEGNLTFLEVEREKQEVEMRQFLDKYEAKSLGWRQALDDRDKEVERLKKQLEGKSISSGQTNSSNSQSQQEEEHAKLRQLLESREQRIEKLEEKIKSMAEEMVSSTRAMNQLCQEKERAHDPEQPRACCQMIEERLREATARCQQLSEMLEAAEQDNVLKSQQALHAISALEAYKRDEDGLIPALRRCSGLEQKVAARDKQLRAYIQELNSLHEVVQENELLRRKLHIPDDVVIMAKNVHSKQRNKDKQIERLTLKLRTSEELRLQLKLEKSELRRKLLELQQDSPQTLNESLQAPSEVGEVPHSVHLENSPRRGQGDGAASSEMQNRYDEVLAENETLRSGMYEILEKLREYDATSEHITIDSDLLRRLIEALPGGTTTPQRLQGQLLELKAREEALRQLLEQQNYSDSETGELSSVHSLCEVPEIAEEHPVEEDAVLNTATRPSSPTEATMGLRRPTVPDPEEKPTNEALAELSILRKHYDELRLHMSADGSDLMNRNQELHDQMIALELQLEQQRNSYSYMRRDYDQLLTETRKQELRFIDDKASLARQLEHSKSELCEAREELEQVNRRNLYTAEEQQKLEHRNAILSMQLGQAMEQLLGELKPTEICAEYGIIRENYQLDYITAQDFEEQQQELLTWRSKQAELQRETKQLEGLLHVANEQIHSQQRLLNEITDNHINLRHLVADLQSSSDEKLMLAKVQRDLDSVKAECSRLETEREKLQLKADCLQTQLEASELSLKQTQQDFQQERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQRRLEEEQVQQRHRDHTALIDEVTAVVQAKIGLNEESSQQLVKLIKSETQTRLLEQRCEILQAKQEELVRELGELRMSQATDTEHWSTIQALFGEGEPRSQLKVDAETNTDAVAPNLAMRRAVQLIDRESSPIGSPLRKHPHLDTATQTLEAQVEFSETAVQTNGILSQQNQAVQTADAVEDNRRDSRAELQKMQETLQEANQRIEILGKQLEASRSESRESASPQGGVVEKTILSFHTLLLEKDQSIQKYQDLLQTERDQSQQALSKQVAENESLRATVNNLNFNIKTKDAEIQGLKEKLRQKPEVPVERNPSTDSRSSSSSDSSVNELTDEKIEELFESSSVERPPQEELEVPVEAGPENIVTEEPEGEEEKQDTEELKEVPTLHKQIKDLKDKLEYSERSLKTREEEVDILKEKLKLCQEREKSVESTVNPELDQLRIFLDEKDKHIKDLMDTLKNFHDDQQRYIKDTSNFSEDQIAKLAADLNRTEATNKIYHTQMEALRRQLANVTQREKQARDLSQSLRQQLLKRPVVSIKTELNARVKNENQLKRIQQLELDLDEARGQLQRQQTLLEAKRTRSANEVQLWEKQKRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKDKQILESKLGRNGPPSNSSGGNNLKCCRTPSCPNLQHVGVSKFAPSPSESPETYTGPSSECSSPAHHHTQIFDQSQLDLIEALKSRIELQQRKIIAMELEGRGSNALTTELEKLQERCQAIEAQNIRLEARNLQLQLDSDLLRQGDSSDRLQKRIKHLEDYIMALKEEMARNESRRELGSGLKVSTNQGQSAEQTILSLRNLVEKLRSENKFLKDGRRSTESRSSMDSTPAEAARLQQQHAEALEKISALQQELQKRTTKCSQCGGRSKDAANEELKFIKEQLVKKTQLLQKAKVLLTRAAAKEKVLREQLALWKRKCSELQNVPVIDEISE
What is the function of this protein?
Essential for ciliogenesis in sensory neurons and spermatocytes (PubMed:25447994, PubMed:30013109, PubMed:31821146, PubMed:33370260).  During neuron and spermatocyte ciliogenesis, essential for initiating transition zone (TZ) assembly and is required for the formation of diverse connections between microtubules and between microtubules and the membrane (PubMed:25447994, PubMed:30013109, PubMed:31821146, PubMed:33370260).  Regulates TZ assembly by recruiting DZIP1 to the plasma membrane where it promotes early ciliary membrane formation resulting in the initiation of TZ assembly (PubMed:31821146, PubMed:33370260).
What are the official names of this protein?
Centrosomal protein cep290.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes at the transition zone (TZ), a region between the basal body and the ciliary axoneme in the olfactory, auditory and spermatocyte system (PubMed:30013109, PubMed:33370260). In sensory neurons, localizes to the transition zone at the tip of the mother centriole (PubMed:25447994). In germ cells, component of the spermatocyte primary cilium and spermatid ciliary cap (PubMed:25447994, PubMed:27646273, PubMed:27577095).