PharMolix/UniProtQA huggingface dataset:
Protein: HEXI1_HUMAN
Sequence: MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD
What is the function of this protein?
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869).  Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869).  May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550).  Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
What are the official names of this protein?
Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1.
What is the protein family that this protein belongs to?
Belongs to the HEXIM family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050).
Protein: ILVC_PRB01
Sequence: MKIYYDEDANIEIIKGMNVSIIGYGSQGNAHANNLHESGVSVTVGLREGSSSWAKAEEAGLKVQTVADSVIQADLVMILAPDEFQKNIYETEIKPNLKTSAILAFAHGFNIHFEKIVPEATNSVIMIAPKGPGHTVRSTYTNGGGVPSLIAIYEDALSDEDYSAKDVALSYAKANGGTRAGVLETSFKEETETDLFGEQAVLCGGLTALIKAGFETLVEAGYSEEMAYFECLHETKLITDLIQEGGIANMHYSISNTAEYGDYVSGPKVITSDTKKAMKGILENIQSGKFADDFLNDCRQSNDGTGGPVMKSNREATKIHPIESVGAELRSKMKFLNSQKLVDKEIN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RLMH_BACMK
Sequence: MNISIISIGKLKEKYLKQGIAEYLKRLSSYAKVEVIELPDEKAPENLSAAEMLIVKEKEGIRILDKISDDTHVIALAIEGKQKSSEEFAVSIDRLATYGKSKITFVIGGSLGLSSEVMKRSNESLSFSKMTLPHQLMRLVLLEQVYRAFRINRGEPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ITR1_CRYNH
Sequence: MSARPAQPNIYAPIRTSLSGYPSPTHSGSSTPASLEFSDGRLPENNVERDMSKVVERVALLGEADEGAVIVEGEDKVTKFVWMLVSAAAISGLLFGYDTAAISGMLVIIKDDLGTILSSWQKEVITSATTLGALLGGLAAGCVSDFTGRRLVIVFANVAFIGGSICQAACHTVAAMIAGRFIVGLGVGLASCIVPLYIGELAPTMIRGRLVTINCVAVTLGQVVAYAIGASFQNVHNGWRWIVGLGAMPSFVQLAAIGFLPESPRILLLRSDVAGARAITAKIYPLATIEQVDRKIEIMKAAVDQSIEYNANSTWFERLKSLVMVGTNRRALIIGCGLQAAQQLCGFNTLMYYSATIFAMLGFNNATAVGLIVATVNVLFTLVALKIVDPVGRRRTMLFTLPIMILALVFAAIFFYYLTLSTNGILIEDHDYPRSLSILVLLSMLLYVAGYATGLGNIPWQQGELFRLEVRGIGTSICTAVNWSCNMLIAGTFLSLMDAATPSGAFGIYAGFCVIGWVFCWMLYPETSGLSLEEVYFVFEEGFGIKKSQQLRKQKLVEAAKLKAIFE
What is the function of this protein?
May function as a transporter or as a sensor for myo-inositol.
What are the official names of this protein?
Myo-inositol transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Protein: METN3_ALKCK
Sequence: MISLKGISKTFKTKNGAVQAVDNVNLEIEAGQIFGIIGYSGAGKSTLIRLLNLLEKPTEGSVKIDGKALSSLTPSKLRAARQEIGMIFQHFNLLWSRTVRQNISFPLEVAGVPAAQRKKRVEELIELVGLHGRGDSYPSQLSGGQKQRVGIARALANNPKVLLCDEATSALDPKTTDSILDLLLDINEKLNLTIVLITHEMHVIQKICHQVAVMENGKIVEQGPVIDVFRKPKEQMTKEFVKQLAQTGEEEQSLWHLLDEKSDGTIVSLTFVGNPAEEQLVTELIRRFPIDISILQGNISKLQQGSYGKLYLRLLGATNEIEAALAYIRGKEIDVEVIEHDR
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 3.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GLMS_NEIG1
Sequence: MCGIVGAIRAHHNVVDFLTDGLKRLEYRGYDSSGIAVYSDGKIKRVRRVGRVQLMEDAAREKGISGGIGIGHTRWATHGGVTEPNAHPHISGGMIAVVHNGIIENFESERKRLEGLGYRFESQTDTEVIAHSINHEYAQNGGRLFEAVQEAVKRFHGAYAIAVIAQDKPDELVVARMGCPLLVALGDDETFIASDVSAVIAFTRRVAYLEDGDIALLASDGIKRLTDKNGLPAERKVKVSELSPASLEPGPHSHFMQKEIHEQPRAIADTAEVFLDGGFIPENFGKNAKSVFESIRSVKILACGTSYYAALTAKYWLESIAKIPADVEIASEYRYRSVIADPDQLVITISQSGETLDTMEALKYAKSLGHRHSLSVCNVMESALPRESSLVLYTRAGAEIGVASTKAFTTQLVVLFGLAVTLAKVRGVVSGEDEARYTEELRQLPGSVQHALNLEPQIAAWAQQFAKKTSALFLGRGIHYPIALEGALKLKEITYIHAEAYPAGELKHGPLALVDENMPVVVIAPNDSLLDKVKANMQEVGARGGELFVFADLDSNFNATEGVHVIRAPRHVGELSPVVHTVPVQLLAYHTALARGTDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_POLNA
Sequence: MNWLDTVRWDDKGLVPVIAQEAASGDVLMFAWMNREALQKTAELGQAVYFSRSRGRLWHKGEESGHLQTVHEIRLDCDSDVVLLKVTQLGHEPGIACHTGRHSCFFSLYKDGQWVATEPVLKDPASIYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_PSEFS
Sequence: MIQTQSMLDVADNSGARRVMCIKVLGGSHRRYAGIGDIIKVTVKEAIPRGKVKKGQVMTAVVVRTRHGVRRADGSIIRFDGNAAVLLNNKQEPIGTRIFGPVTRELRTEKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RS9_CLOB1
Sequence: MAKVQYFGTGRRKKSVARVRLVAGDGKVIINNRDIENYFPIETLRVIVNQPLVLTETKDKYDVLVNVHGGGFTGQAGAVRHGISRALVKADENMKSSLKKAGFLTRDPRMKERKKYGLKKARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RL7_XANC8
Sequence: MSLTNEQIVDAIAEKSLMEVMELVKAIEEKFGVSAAAPVAAAAAGPAAVVEEQTEFTVVLTSPGANKVAAIKAVRGVTGLGLKEAKDLTEAGGILKEGVSKDEAEKIKKEMTEAGATVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PDLI3_MOUSE
Sequence: MPQNVVLPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTHADAQDRIKAASYQLCLKIDRAETRLWSPQVSEDGKAHPFKINLEAEPQEFKPIGTAHNRRAQPFVAAANIDDKRQVVSASYNSPIGLYSTSNIQDALHGQLRGLIPGSLQNEPTASVPPQSDVYRMLHDNRDDPAAPRQSGSFRVLQDLVNDGPDDRPAGTRSVRAPVTKVHGGAGSAQRMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFVEGELYCETHARARTRPPEGYDTVTLYPKA
What is the function of this protein?
May play a role in the organization of actin filament arrays within muscle cells.
What are the official names of this protein?
PDZ and LIM domain protein 3, Actinin-associated LIM protein, Alpha-actinin-2-associated LIM protein.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.
Protein: GCSH_SYMTH
Sequence: MANVPADLKYSKEHEWIRVEGNIGIVGITWFAQDQLGDVVFVELPEVGRELKQNEQFGVVESVKTVSDLYCPASGKVVEVNTKLESSPELINQDPYGEGWILKLELSNPAELDNLLDAAAYDAFTKEG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: YFEO_ECO24
Sequence: MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASALQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPITHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMNQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV
What are the official names of this protein?
Putative ion-transport protein YfeO.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: METK4_HORVU
Sequence: MAEVETFLFTSESVNEGHPDKLCDQISDAVLDACLAEDPDSKVACETCTKTNMVMVFGEITTKANVDYEKIVRDTCRGIGFVSNDVGLDADHCKVLVNIEQQSPDIAQGVHGHFTKRPEEIGAGDQGHMFGYATDETPEFMPLSHVLATKLGARLTEVRKNATCPWLRPDGKTQVTVEYHNDNGAMVPIRVHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEQYLDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIARQAAKSIVASGIARRCIVQVSYAIGVPEPLSVFVDTYGTGKIPDKEILEIVKENFDFRPGMIIINLDLKRGGSGRYLKTAAYGHFGRDGADFTWEVVKPLKWEKPSA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 4, AdoMet synthase 4, Methionine adenosyltransferase 4, MAT 4.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPRF_MYCBO
Sequence: MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG
What is the function of this protein?
Might be involved in transporting short diacylated glycolipids to the cell outer membrane.  Binds glycolipids that contain a diacylated glycerophosphate or a diacylated phosphatidylinositol moiety with C14 and C16 chains (upon overexpression in M. smegmatis; M. smegmatis does not encode this gene).  Overexpression in M. smegmatis increases the cell wall glycolipid LAM/LM ratio (lipoarabinomannan/lipomannan), suggesting perhaps this protein is involved in the preferential translocation of diacylated LAM to the outer cell membrane.  Overexpressing M. smegmatis cells adhere less well to hexadecane droplets, indicating decrease in the hydrophobicity of the cell surface, and have a slightly increased resistance to the antibiotic ethambutol.
What are the official names of this protein?
Putative diacylated glycolipid transporter LprF, Lipoprotein LprF.
What is the protein family that this protein belongs to?
Belongs to the LppX/LprAFG lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: CYB_CORCX
Sequence: FGSLLGLCLITQIITGLLLAMHYTADTSLAFTSVAHMCRNVQFGWLIRNLHANGASFFFICIYLHIGRGIYYGSYLNKETWNIGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWLWGGFSVDNPTLTRFFAFHFLLPFVIAGLTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYSIKDLLGFALMLIPLITLALFSPNLLGDPENFTPANPLATPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPLLHVSKQRSMTFRPLSQILFWTLVADLLILTWVGS
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CDC37_RAT
Sequence: MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADQQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDISA
What is the function of this protein?
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.  Inhibits HSP90AA1 ATPase activity.
What are the official names of this protein?
Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37.
What is the protein family that this protein belongs to?
Belongs to the CDC37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_AZOVI
Sequence: MPKMKTKSGAKKRFKPTASGFKHKHAFKSHILTKMTTKRKRQLRGTSLMHPSDVAKVERMLRVR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: HUT1_CRYNB
Sequence: MGVLRLAVCISGVYAAFLLWAIAQERLSKPFPSVHPHPHQQPHSPSDPPPGDKFPSPLFLNFAQALASSLSALCYLSFKAWRDGWKGRGLGQLLGLKEVFGKSQTALNGDAKANKKESELNEKTKEVVEKAPKPPKKSLLALLVQVSVFQTIASPIGFLALRHISYPTMVLGKSCKLIPVLLLNVLLYRRKFSPHKYIVVALVTVGISMFMLFAETSKKKKGGSDSMWGLVLLLVNLLIDGLTNSTQDQIFSSYPSYTGQQMMFTMALTTQIILLPLLVLPLPTNPISLLAHLPPPFGSSVPTSTLSFSPPAALESISFLLSHPSALAPLFAYALLGGLGQLFIFETIQHFGSLTLVMVTVTRKLFTMLLSVVVFEHRLTKGQWLGVGVVFAGIGVEAGMKRKDVMKKAKKD
What is the function of this protein?
May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen.  Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity).
What are the official names of this protein?
UDP-galactose transporter homolog 1.
What is the protein family that this protein belongs to?
Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YG3N_YEAST
Sequence: MKWKVLQLKTQEIKVNNLAKSSLHQPGSLVLRNRIRNNQTISNHQKVYITNLHKDKLKLNNLLRLMKSTNRHMPFRNLVLATGQELALLHNKRKRRKTLPLALFYSHLILL
What are the official names of this protein?
Uncharacterized protein YGR151C.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PYRF_ARCFU
Sequence: MKQLILALDVMDGEKAMEIAKKVAEHVDRIKVNYPLVLSAGVGIMKRLSEIKPVIADFKIADVPYTSSLIARIAFENSAESVIVHGFVGSDTLREVCRVAEEFGGKVYAVTELSSPGGEEFMSAVSLKIVEKAKEAGCHGLIAPSTRIERLREIRKAAGDMEILCPGIGAQKGSIEAVKYADGIIVGRGIYASGNPAEEARKLRRVLKI
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: CHED_SYNWW
Sequence: MSKIIQVGMADFKMATAPDKLITAGLGSCIGICLYDKVIKLGSLTHIMLPSSSQAKNASNEAKFADTGLKLAIREMEKNGAQASRLLAKIAGGAQMFKFSGESDIMKIGERNSVAVKENLQLHRIKLLSSDTGGNYGRTIIFDPETGDLLVKTIGHGERII
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: IPGA_SHIFL
Sequence: MCRKLYDKLYEITGAKLDFNDKNQAFILLEEQIPVCITDNDEYIFLTGLLNEHELFTENIINPEHILILNYSLSRDYGSSICLLPDTHQCVLTKKHYKKYLSPDELIESLYEFLFCIKLTIANITSEVN
What is the function of this protein?
Molecular chaperone required for IcsB stabilization and secretion.
What are the official names of this protein?
Chaperone protein IpgA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_VARPS
Sequence: MIAASIKAEVVKDNARAANDTGSPEVQVALLTARINELTPHFKTHAKDHHGRRGLLRMVSRRRKLLDYLKSKDADRYTALIAKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SOSSC_DROAN
Sequence: MAFPTTSAQQADTTRKILEEIQTKKQLLAGGIINLGINTQMSTPQLLGQPTTVTPDFQLGVGGVAANATPTARAAFNPTSSTTLGFFVPQDSYFGNSFLPVLPRLEPLPSSIATPPATPINNK
What are the official names of this protein?
SOSS complex subunit C homolog.
What is the protein family that this protein belongs to?
Belongs to the SOSS-C family.
Protein: TRUD_SYNC1
Sequence: MANYLTAKLPGIGGSIKTCPDDFLVEELPLYPTCGEGEHLYLEVEKRGMTTFELLKRLSRALQVNERAMGYAGLKDAQATTRQFISVTDCSAEQALALQLQDIRILSARRHRNKLRLGHLAGNRFTITIRDIDSDALEKARDILHVLQMTGVPNFFGEQRYGALGNSHLIGQAIVQKNFSQAAAHIIGDPDKIIHPEWRQGAILYAENRLEEAEQALPRRMRNERNLVRSLRQGRSAEKAVRRLPGKLLRLYLSAYQSHLFDRLVSMRLESLETLWTGDIAYKHDNGACFLVTDAALEQPRADRFEISPTAPLFGHKVMMAEAQAGILEQALLAKEGITPDDFRLGAGLSMPGERRPLRIPISETASNQQGNELELSFSLPKGSFATTVLHEVMKTDV
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: HIF1N_HUMAN
Sequence: MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
What is the function of this protein?
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD).  Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator.  Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases.  Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.  Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively.  Negatively regulates NOTCH1 activity, accelerating myogenic differentiation.  Positively regulates ASB4 activity, promoting vascular differentiation.
What are the official names of this protein?
Hypoxia-inducible factor 1-alpha inhibitor, Factor inhibiting HIF-1, FIH-1, Hypoxia-inducible factor asparagine hydroxylase.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
Protein: NOB1_HUMAN
Sequence: MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPETPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGEDVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQQELEQCDVPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR
What is the function of this protein?
May play a role in mRNA degradation (Probable).  Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
What are the official names of this protein?
RNA-binding protein NOB1, Phosphorylation regulatory protein HP-10, Protein ART-4.
What is the protein family that this protein belongs to?
Belongs to the NOB1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METE_STRR6
Sequence: MSTTIIGFPRLGEFRELKFTTEKYFRKEISEEELLAAAKDLRAKHWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQGEKGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVGPFTFLQLSDFEEGVKADDFVDSFVAAYQEVFAKLADLGATRIQLDEAALVKDLTAEEKALFLNLYNKLLADKKGLEVLFQTYFGDVRDVYADLVNLPVDAIGLDFVEGKKTLELVKGGFPADKTLYVGIVNGKNIWRNNYEKSLTVLEQIPAENIVLTSSCSLLHVPFTTANEEFEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAGLTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKEYDAFLAETIDEWIKWQEDIDFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGMRGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTILNWSFPREDISIKDSTLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVHSTVAPDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVGPGVYDIHSPRVPNEGEIDNTIEAILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVEAAKAAREKL
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: CAS5B_SACS2
Sequence: MKGVVIFGIHHWGFSVRVPRTSAGGSSYIVPPITTILGALSRGYCSDYAVKNNVSCTKEFIDKFSSDLFWVTYGTEEHMLMPYSDLLREERVPYRQSKNRSLDHVSDWFGVSAFGKVYCENVNFSILLLLNKENSEFWSKLGWQIISLGTKESLVTITDVKVVDVEESSDEDIYTIYYIPAECLTNTEEFEVVNMPVKSVYELSSKPSIGVFSNFLVPRKTPFIGGKVKVKKSNVRGDICKVYKMADKYVITFKEGLEKWYSK
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
What are the official names of this protein?
CRISPR-associated protein Cas5 2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.