PharMolix/UniProtQA huggingface dataset:
Protein: FETP_BLOPB
Sequence: MSKIIYCVFLKKYAEGLDAPCYPGALGKYIYEHISNIAWMQWQDKQTILINENKLNMMNIADRTILEKEMKIFLFGKNFSIKNN
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: CITG_ECOHS
Sequence: MSMPATSTKTTKLATSLIDEYALLGWRAMLTEVNLSPKPGLVDRINCGAHKDMALEDFHRSALAIQGWLPRFIEFGACSAEMAPEAVLHGLRPIGMACEGDMFRATAGVNTHKGSIFSLGLLCAAIGRLLQLNQPVTPTTVCSTAASFCRGLTDRELRTNNSQLTAGQRLYQQLGLTGARGEAEAGYPLVINHALPHYLTLLDQGLDPELALLDTLLLLMAINGDTNVASRGGEGGLRWLQREAQTLLQKGGIRTPADLDYLRQFDRECIERNLSPGGSADLLILTWFLAQI
What is the function of this protein?
Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.
What are the official names of this protein?
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: INP1_YEAST
Sequence: MVLSRGETKKNSVRLTAKQEKKPQSTFQTLKQSLKLSNNKKLKQDSTQHSNDTNKSVKAKKNGTSSKKTGTQRKRISTQRFSLFTYGNVQVMNSFVPIHNDIPNSSCIRRNSQVSANNVTESSGVFFNDTQSQDSQNTIKLKPTSLMAKGPIEIYQICTGFDKLKENIAPFQKSSKASSHDGHVVNYLSIGRHGDIVHPVLPKLQITRLNGAGFKYFISFYNPERYWEIEFLPLISQSQSELENSVKAFENVISKICQFSHINEGATIGNNESLSDKFKLPPTSDIEPPNTEIINNDDDNDDDDDNYDDDDLNYLLDEEYEQGCTDNSFSVISNTCSNLNASFLYPSDPTDAVSISINEAFKNAIRRTAPVLNIPIAAPSIHSKQQNKRYSSYPFIDSPPYLQDRHRRFQRRSISGLGDL
What is the function of this protein?
Required for peroxisome inheritance.
What are the official names of this protein?
Inheritance of peroxisomes protein 1.
What is the protein family that this protein belongs to?
Belongs to the INP1 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Peripheral membrane protein.
Protein: FMT_PASMU
Sequence: MTSLKIIFAGTPAFAAQHLQALLNSHHQVVAVYTQPDKPAGRGKKLQASPVKQLAEQHNIPVYQPKSLRKVEAQEEMRAIDADVMVVVAYGLILPQTVLAMPRLGCLNVHGSLLPRWRGAAPIQRAIWAGDKQTGITIMQMDEGLDTGDMLYKVYCDIAQDETSTSLYAKLMEIAPPALLHVLDGLDKGKFVSEKQDDIESCYAEKLSKEEAELNWHVSAEQLERHIRAFNPWPVSYFSTRDLQGNTQVIKVYKAAVLPHVDKVAGTILSADKNGIQIATAEGVLNLLQLQPAGKKPMDARDLLNGRAEWFPVGKVL
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: GP143_HUMAN
Sequence: MASPRLGTFCCPTRDAATQLVLSFQPRAFHALCLGSGGLRLALGLLQLLPGRRPAGPGSPATSPPASVRILRAAAACDLLGCLGMVIRSTVWLGFPNFVDSVSDMNHTEIWPAAFCVGSAMWIQLLYSACFWWLFCYAVDAYLVIRRSAGLSTILLYHIMAWGLATLLCVEGAAMLYYPSVSRCERGLDHAIPHYVTMYLPLLLVLVANPILFQKTVTAVASLLKGRQGIYTENERRMGAVIKIRFFKIMLVLIICWLSNIINESLLFYLEMQTDINGGSLKPVRTAAKTTWFIMGILNPAQGFLLSLAFYGWTGCSLGFQSPRKEIQWESLTTSAAEGAHPSPLMPHENPASGKVSQVGGQTSDEALSMLSEGSDASTIEIHTASESCNKNEGDPALPTHGDL
What is the function of this protein?
Receptor for tyrosine, L-DOPA and dopamine.  After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells.  Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway.  Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.
What are the official names of this protein?
G-protein coupled receptor 143, Ocular albinism type 1 protein.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor OA family.
What are the subcellular locations of this protein?
Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673).
Protein: Y4033_VARPS
Sequence: MAFKDLPAHARPREKLIARGAAALADAELLALLLRTGVAGKNVLQLAQELLDHFGGLSGLLQTSAEDLKVIKGMGGDAKRAELIAVLELARRAMAERLKERTVFDSPGTVKQYLQLHIGSRPYEVFAVLFLDAQHRLIVLEELFRGTLTQTSVYPREVVTRALHHQAAAVVLSHNHPSGSIEPSRADESLTQTLRAALSLIDVRVLDHVIVSAGQSYSMAEKGLL
What are the official names of this protein?
UPF0758 protein Vapar_4033.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: B3GNL_MOUSE
Sequence: MEVSENATTRGSLALVSIILPVHNAEQWLDECLMSVLQQDFEGAMELSVFNDASKDKSRAIIEKWKVKLEDSGISVVIGGHDSPSPRGVGYSKNQAVAQSTGSYLCFLDSDDVMMPQRVRMQYEAAGQHPTSIIGCQVRRDPPDSTERYTRWINHLTSDQLLTQVFTSHGPTVIMPTWFCSRAWFSHVGPFDEGGQGVPEDLLFFYEHLRKGGGVFRVDHSLLLYRYHLYAATHSVLEMTIWTHRVHFLEEQVLPHWKSFTIWNAGKQGRKLYRSLTAASRHKVVAFCDVDENKIRKGFYCYEDSQERPKPKVPILHFQAAQSPFVICVKLDLTGGEFEDNLKSLDLQEGRDFVHFS
What is the function of this protein?
Putative glycosyltransferase.
What are the official names of this protein?
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1, BGnT-like protein 1, Beta1,3-N-acetylglucosaminyltransferase-like protein 1, Beta3Gn-T-like protein 1, Beta3GnTL1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
Protein: DNAA_EHRRW
Sequence: MNNDNTEVLENYPQDGLQSNSHIIWKGIQSRLHKFYGNAIYDSWLSVLLYVSTESGKVLLSAPTRFIKEWILVHYLDQILKYWQDEDQSICSVDICVVSNQDPNLLVDIKDRVDRGIKGNCDNVSSPLDPRFTFDNFVVGKPNELAFAAARRVAESNSPISGSNPLFLYGGVGLGKTHLMHAIAWYIIKSCSKRKIAYLSAEKFMYQYVTALRSKDIMLFKEQFRSVDILMVDDVQFISGKDSTQEEFFHTFNALIDQNKQLVISADRSPSDLDGVEERIKSRLGWGLVADINETTFELRLGILQLKVEKMGINIPNKVLEFLAKNIKSNIRELEGALNKVVAHSSLVGCSITLDTASDILSDLLRANHKSVTLECIQKKVAEFFNIKVSDMYSTRRLRTLARPRQIAMYLSKKLTQKSLPEIGKSFGGRDHATVIHAVKQIEKLMDTDSKLRDDINLLNRMLR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_DECAR
Sequence: MRLNTIKPGEGSKKTAKRVGRGIGSGLGKTCGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFNSLTRARNYEVRLTDLDRLPVDEIDLLALQVAGIVPGDALSAKVILSGAISRKVVLKGVGATKGAKAAIEAVGGSIAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CRCB1_METMA
Sequence: MLPAANIGDLFLIGTGGFIGASLRYTISSRMPKIRSIPAGTLTVNFLGSIVLSLLTFSSEPESVVYLVNIGILGSFTTFSTFAYETFKLLEDGQNVSFFLNIFLNVILCLLGVGIAYFALRL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GREA_PARDP
Sequence: MEKIPMTRAGYDQLDEELRELRSVQRPAVIRAIAEAREHGDLSENAEYHAAREKQSFVEGRIKELEMILSRAEVIDPTRLNGSIKFGATVTLVDEDSEEERTYQIVGEAEADLERGLLNIRSPLARALIGKDEGDSIEVVTPGGGKSYEIISIRYV
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: SYC_RICBR
Sequence: MQIYLFNTLTQNKELFEPEDQTNVKMYVCGPTVYDNPHIGNSRSVVVYDLLYRILVDIFEAKSVKYVRNITDVDDKIIERAANLGISINELTDKVTKEFHTNMKYLFCLPPTIEPKATQHIDVMIEIIEKLIKSGHAYIADDHVYFDVLLAPNYTELSNRKLEDMFESVRVENSKTKKHPQDFVLWKPAKPDEDVHMNFKSPWGLGRPGWHIECSAMSYKYLGKNFDIHGGGADLIFPHHTNEIAQSKCAFSNSTYAKYWVHNGFLTVNGEKMSKSLGNFITVRDLMDKQIKGEIVRLFLLTAHYRRPLDYNDKAIEDAKKTLDYWYRAIQNINIQKIDTLPSDFMQSLFDDMNSPLAIKIINDYAKAIFTATNEEEKQFNASNLIACANFIGLMNETPHEWFNKDVDENYINNLINERLEAKKQKNWGLADQIRNKLLNEKIILEDKPNGTTIWRKE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT12A_RABIT
Sequence: MAGGAHRADRATGEERKEGGGRWRAPHSPSPPGPRGCPVPLKAAAQSLCRKPTWGRYCTLLLFQRKLEIYSVELHAATDIKKKEGRDGKKDNDLELKRNQQKEELKKELDLDDHKLSNKELETKYGTDIIRGLSSTRAAELLAQNGPNALTPPKQTPEIIKFLKQMVGGFSILLWVGAVLCWIAFGIQYVSNPSASLDRVYLGTVLAVVVILTGIFAYYQEAKSTNIMASFCKMIPQQAVVIRDSEKKVIPAEQLVVGDIVEIKGGDQIPADIRLLSAQGCKVDNSSLTGESEPQSRSSGFTHENPLETKNITFYSTTCLEGTATGMVINTGDRTIIGRIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSVGILFFIIAVCMKYHVLDAIIFLIAIIVANVPEGLLATVTVALSLTAKRVAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDNLNQGFDQSSGTWTSLSKIIALCNRAEFKPGEESVPIMKRVVVGDASETALLKFSEVILGDVMEIRKRNHKVVEIPFNSTNKFQLSIHQTEDPNDKRFLLVMKGAPERILEKCSTIMINGKEQPLDKSMAQAFHTAYMELGGLGERVLGFCHFYLPADEFPETYSFDSESMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAKRCNIAVEQVNKRDAKAAVVTGMELKDMSPEQLDELLANYPEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGVAMGITGSDAAKNAADMILLDDNFSSIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLIYIILGLPLPIGTITLLFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNQQLAVYSYLHIGLMQALGAFLVYFTVYAQQGFRPTSLFHLRIAWDSDHLNDLEDNYGQEWTSYQRQYLEWTGYTAFFVGIMVQQIADLIIRKTRKNSIFKQGLFRNKVIWVGIASQIIVALLLSYGLGSITALNFTMLKAQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY
What is the function of this protein?
The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells.  Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (By similarity).  Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity).  In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (By similarity).
What are the official names of this protein?
Potassium-transporting ATPase alpha chain 2, HK alpha 2, Non-gastric H(+)/K(+) ATPase subunit alpha, Non-gastric Na(+)/K(+) ATPase subunit alpha, Proton pump, Sodium pump.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi- pass membrane protein.
Protein: DUT_JANMA
Sequence: MKTIEVKILDPRMQEQLPAYATAGSAGLDLRACLDAPITIKPGETHLVPTGLAIHLADPGYAAMILPRSGMGHKHGIVLGNLVGLIDSDYQGQLMVSTWNRGQTEFTLNPMERLAQLVIVPVLQVGFNVVEEFDTSERGIGGFGSTGKH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RSMH_HYDS0
Sequence: MHKSVLLKEVTDFLSNPCPKIHIDATLGLGGHAKALLEVCKDTFLIGIDKDENAIEIAKEKLKGFNAVFYHGSFKDFDIVLKEEGLLYFDSILFDFGVSSLQLDEEEGFSFQREDFLDMRMDKRQQKTAYIVINTYKEKELADIFYKYGEERLSKKIARSIVEKRKKKPIETTKELVDIVSSCYPYKYSKINPATKVFQALRIEVNSELEDIKIALSKLLDFAKEGSKFAFISFHSLEDRLVKEFIKNNADKLKVCSKKPITPSDEELLYNKRARSAKLRCAKLCYNEKKDEAFDS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KIN4_YEAST
Sequence: MASVPKRHTYGGNVVTDRDRHSLQRNNEILHPIHKNQRKHATFGPYIIGSTLGEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKLENLLLDKHENLVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTGDDIARLYKYITQTPLKFPEYITPIPRDLLRRILVPNPRRRINLQTIKRHVWLKPHEAFLSIQPNYWDEHLQKERPKPPNKGDVGRHSTYSSSASSYSKSRDRNSLIIESTLEQHRMSPQLATSRPASPTFSTGSKVVLNDTKNDMKESNINGERTSASCRYTRDSKGNGQTQIEQVSARHSSRGNKHTSVAGLVTIPGSPTTARTRNAPSSKLTEHVKDSSQTSFTQEEFHRIGNYHVPRSRPRPTSYYPGLSRNTADNSLADIPVNKLGSNGRLTDAKDPVPLNAIHDTNKATISNNSIMLLSEGPAAKTSPVDYHYAIGDLNHGDKPITEVIDKINKDLTHKAAENGFPRESIDPESTSTILVTKEPTNSTDEDHVESQLENVGHSSNKSDASSDKDSKKIYEKKRFSFMSLYSSLNGSRSTVESRTSKGNAPPVSSRNPSGQSNRSNIKITQQQPRNLSDRVPNPDKKINDNRIRDNAPSYAESENPGRSVRASVMVSTLREENRSELSNEGNNVEAQTSTARKVLNFFKRRSMRV
What is the function of this protein?
This protein is probably a serine/threonine protein kinase.
What are the official names of this protein?
Serine/threonine-protein kinase KIN4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: APOC2_RAT
Sequence: MGSRFFLALFLALLVLGNEVQGTEEDDPGSSALLDTVQEHLFSYWNSAKAAAGELYQKTYLTSVDEKLRDMYSKSSAAMTTYAGIFTDQLLTLLKGE
What is the function of this protein?
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma.  Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
What are the official names of this protein?
Apolipoprotein C-II, Apo-CII, ApoC-II, Apolipoprotein C2.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOI1_RHOP2
Sequence: MIGWLEAMLRVGRKLFVKAETQLYPEEKPKLFPRSRGRIVLTRDPDGQERCVACNLCAAVCPVGCIDLSKAVADDGRWYPEHFRINFARCIFCGFCEEACPTAAIQLTPDFELGEWRRDALVYEKHDLLIAGEGKVRGYRYWSVAGKAIDGKDKGCAENESPPVDLKGLLP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I 1, NADH dehydrogenase I subunit I 1, NDH-1 subunit I 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MFPP_AGRFC
Sequence: MKPLRLLSTDLDGTVVGDNDATRRFRDFWHALPDDLRPVLVFNSGRLIDDQLALLEEVPLPQPDYIIGGVGTMLHAKKRSELETAYTQSLGTGFDPRKIADVMNRIAGVTMQEERYQHGLKSSWFLHDADAAALGEIEAALLAADIDARIVYSSDRDLDILPKAADKGAALAWLCGQLRIGLDESVVSGDTGNDRAMFELKTIRGVIVGNALPELVSLAHQDNRFFHSTAKEADGVIEGLRHWGLNPR
What are the official names of this protein?
Mannosylfructose-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the sucrose phosphatase family.
Protein: CHZ1_CHAGB
Sequence: MSAQNSTDPMGATNPENGGATATDLKGKGRAPAAQEPVEDTSMAEDDDDDDDEEDPEEEPEAADDDNMEEIDLDNVIGRRTRGKVIDFANAAQENPADDDDEEDDDDFVEDDNKMDDSKMDED
What is the function of this protein?
Forms a chaperone-bound H2A. Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A. Z histone replacement in chromatin.
What are the official names of this protein?
Histone H2A.Z-specific chaperone CHZ1.
What is the protein family that this protein belongs to?
Belongs to the CHZ1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TYSY_PSEMY
Sequence: MKQYLDLMRHVREHGTFKEDRTGTGTYSVFGYQMRFDLADGFPIVTTKKCHLRSIIHELLWFLQGDTNIKYLKDNGVSIWDEWADENGDLGPVYGYQWRSWPAPNGESIDQIAKLIEMIRKNPDSRRLIVSAWNPALVEQMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVCDLQPGEFIWTGGDCHLYANHIEQADLQLTRQPLPLPTMKLNPEVKDLLAFRFEDFELVGYEAHPHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_ARTIO
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWLLRYLLANGASMFFICLYLHVGRGLYYGSYMYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIETDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLMMLTALATLVLFSPYLLGDPDNYIPANPLITPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIVPTLHMSKQRSMMFRPLSQCLFWLLVAVLFTLTWIGGQPVEHPYIIIGQTASILYFLIILFLMPMISLVENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: URE1_BEII9
Sequence: MAVTLPRPAYAGMFGPTTGDKVRLADTELFIEIERDFTLYGEEVKFGGGKVIRDGMGQGQASKAEGAADTIITNAVIIDHWGIVKADVGLRDGRIIGIGKAGNPDVQPGIDLIIGPGTEIIAGEGRILTAGGFDSHIHFICPQQIEEALASGMTTMLGGGTGPATGTFATTCTPGPWHIARMIEASDGFAMNLGFAGKGNASRSEGLVEQIEAGACALKLHEDWGTTPAAIDCCLSVADDHDIQVMIHTDTLNESGFVEDTIRAFKGRTIHAFHTEGAGGGHAPDIMKVAGLPNVLPSSTNPTRPFTVNTLDEHLDMLMVCHHLDPSIAEDLAFAESRIRKETIAAEDILHDLGALSMMSSDSQAMGRIGEVITRTWQTADKMKRQRGPLPEDKSNNDNFRVRRYIAKYTINPAITHGVSRHIGSIEPGKLADLVLWTPAFFGVKPDLVIKGGMIAYAMMGDPNASIPTPQPVHGRPMFGSFGGARTGTSLTFTSKTALAHGLAQKLKISRKLVPVENTRGNLRKTSLILNGAMPHIEIDPETYVVKADGMVLTCEPARSLPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMHR2_RAT
Sequence: MLGTLGLWTLLPAAAQVSPNRRTCVFFEAPGVRGSTKTLGEVVDAGPGPPKGIRCLYSHCCFGIWNLTHGRAQVEMQGCLDSDEPGCESLHCDPVPRAHPSPSSTLFTCSCGTDFCNANYSHLPPSGNRGAPGPQEPQATPGGPIWMAQLLLGVFLVLLLSIIILALLQRKACRVQGGSDPEPEPGSGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHNHIVRFITAGQGGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHGERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPPFQLAYEAELGSNPSACELWALAVAERKRPNIPSSWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPQVASSFPESCPQGCPENCPAAPASAAFPCRPQQSSCLLSVQQGSGSKS
What is the function of this protein?
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.  Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.  Receptor for anti-Muellerian hormone.
What are the official names of this protein?
Anti-Muellerian hormone type-2 receptor, Anti-Muellerian hormone type II receptor, AMH type II receptor, C14, MIS type II receptor, MISRII, MRII.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RT03_MARPO
Sequence: MAQKVNPISVRLNLNRSSDSSWFSDYYYGKLLYQDLNFRDYFGSIRPPTGNTFGFRLGRCIIHHFPKRTFIHVFFLDRLSQSRHQGLGAIPSVKLIRRINDNTVKQRNEVGIWPKKRYEYHDRLPSIQKIDQLLRVSDWMADIHSTFQSIWPKDENDDRRASEERYAFSRFAPSILVAVRAEKKKAIFGSEGDFFGFTGRAFLDYFVMQYFFNLKNQIQFDPMVNRSPVAQGVAKTSMIGKAIPAKTEQGTQSGESICQPRSTLYFDAIIFLRYARFRKATSLSSRYYYLKKMQSLFSNQTKTNTLIQPVKIASVYQSASLIAQEISWKLEQKKSFRQICRSIFKQIKKCPYVKGIRIGCSGRLNGAEIAKTECKKYGETSLHVFSDQIDYAKTQASTPYGILGVKVWVSYFLTQKKGTSCAISKTYKIS
What are the official names of this protein?
Ribosomal protein S3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: UPPP_NEIG1
Sequence: MDFLIVLKALMMGLVEGFTEFLPISSTGHLIVFGNLIGFHSNHKVFEIAIQLGAVLAVVFEYRQRFSNVLHGVGKDRKANRFVLNLAIAFIPAAVMGLLFDKQIKEYLFNPLSVAVMLVLGGFFILWVEKRQSRAEPKIADVDALRPIDALMIGVAQVFALVPGTSRSGSTVMGGMLWGIERKTATEFSFFLAVPMMVAATAYDVLKHYRFFTLHDVGLILIGFIAAFVSGLVAVKALLKFVSKKNYIPFAYYRIVFGIVIIILWLSGWISWE
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBIB_SHEPA
Sequence: MTVKSIRRAYHVIRTALHYGLDDLLPPKLTPWYFKLLRYCFFWLRNQHKDKVGGERLKLAMQELGPVYIKFGQMLSTRRDLLSDEWAEELAMLQDRVPPFDSAIARESIEKELNAPIERYFNDFDDTPLASASISQVHTATLKSNGAAVVLKVLRPDVEKKVHADLLLMSQAADFLERLLGANNRLRPAEVVEDYRTTIEGELNLKLEALNAIKLRNNFIDSNALYIPYMYEELCFTRLIVMERIDGIPVSDKVALEAQGTNLKLLAERGVELFFTQVFRDNFFHADMHPGNVFVSREHPNDPFYIGLDCGIMGTLTDEDKRYLAENFLAFFNRDYRRIAQLYIESGWVSADTDVGAFEQAVKVVCEPMFNKPLDEISFGHVLLELFRTARRFDMVVQPQLVLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLEQWMAEQVGPKAMAAKVKQQLPYWAEHLPELPELIYDNLKIGRDLSKNQNKLLDRYLKHQQKAHKSNYLLITSAILVICGTILLNQDATLWPSYGSIGIGITLWVLGWRSRPKNRKI
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.