PharMolix/UniProtQA huggingface dataset:
Protein: CLE46_ARATH
Sequence: MRRHDIIIKLLLLMCLLLSRFVTRECQEVHFKIGPAKIIAKPNNARVMPTWGEEKKWHKHPSGPNPTGNRHPPVKH
What is the function of this protein?
Extracellular signal peptide that regulates cell fate.
What are the official names of this protein?
CLAVATA3/ESR (CLE)-related protein 46.
What is the protein family that this protein belongs to?
Belongs to the CLV3/ESR signal peptide family.
What are the subcellular locations of this protein?
[CLE46p]: Secreted, extracellular space.
Protein: LFTR_SHESH
Sequence: MNSLSYLNHELERFPSPEYALTDPNGLLAIGGDLHPTRLLNAYYEGIFPWFNADDPILWWSPDPRAVFVPGTMKASRSLIKSLKKQTWTFTINRAFKEVMIGCAAPRAAQDGTWITQDIQHAYLELHKQGLAHSVEVWDEETLIGGLYGLAIGQVFCGESMFHTQTNASKAAMLVLHQYLLKQGFKLIDAQVVNPHLESLGATALKRKDFINLLKRFRDGKVASNSWVVKEVFLEL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_ALKEH
Sequence: MKRLKRTADLRALVADWRREGLRVGLVPTMGNLHEGHLALAEYLAPHCDRLVTSIFVNPLQFGPNEDYESYPRTFGEDCAGLEARGVDAVFAPPVEEMYRGGVRQATRVEVGALAERLCGISRPGHFTGVATVVVKLFNLVQPDVAVFGRKDYQQLRVIEQVVSDLNIPVEVRGMPTVREPDGLAMSSRNGYLTQQERHIAPGLYRTLQGMAKRIRAGDDDYRRLEARGRAMLAEQGFQPDYLEVCRADDLTPAAPGDRGLVVAGAAWLGRARLIDNIELELNRDQ
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGJ_COLP3
Sequence: MPVNLPEIVPASLTPIQGIRLGWAESNIKTQNRKDLLVIEICDGSAVSGVFTQNRFCAAPVTLCKKHLDAVKNNATTGGNVSGIKALVVNTGNANAGTGEQGMLDALTTCQHLAEIMAIPVESILPFSTGVILEHLPMDKLLAGLPLAVTNLTTDNWADAASAIMTTDIAPKAYATQVKVGGESINITGISKGAGMIHPNMATMLGYVATDANITQSLLDSMTKEIADLSFNCISVDGDTSTNDSFIVIATGKSNAVAITSPNDKGYQEVFDALLETSQYLAKAIVRDGEGATKFITVTVKGALSIDEAKTIGFSIGKSPLVKTAMFASDPNLGRVLAAIGYASRECDSLADLDTNQLELYFGGLLVAEKGGRAASYKEDEGQAIMNEAEIDITVQLHRGNEESTIWTCDFSYDYVKINAEYRT
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOC_ROSS1
Sequence: MLEINDFSAIRISLASPEDILSWSHGEVTKPETINYRTLKPERDGLFCERIFGPTKDWECYCGKYKRVRYKGVVCDKCGVEVTRSKVRRERMGHISLASPVSHIWFVKGTPSRLGLLLDISPRNLERVLYFASYMIVHVDEELKAQAREALQAEYREKRERIQQEAESKQIELSTQLTQDLGGMESAQITTQRRIEEEYRRLRDEISAEAERLRSDLEEKQGEAAEEDILFRGTVLIEEGEIITEKTLDALDELLDQELETLEQRKQRDLEDAEQLTGAERERKEYEASQERERLQERLQSELDRLVREEKERLEQIDSIKLKRILSEQEYRALREIAPGVFRADMGAGAVRDMIVRTIDLDKLAEELQNEVYTTQGQRRKKATKRLRVVEAFRKSGNRPEWMILTVLPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLMELNAPEIIVRNEKRMLQEAVDALIDNGRRGRAVSGKGKHRLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPDLKLHQCGLPKKMALELFKPFVMRRLVEKGFAHNIKSAKRIVERVRPEVWDVLEEVIKDYLVLLNRAPSLHRLSIQAFEAKLIEGSAIQLHPLVCAAFNADFDGDQMAVHVPLSRKAQEEARMRMLSKYNLLSPATGDPIITPSQDIVLGCYYLTMVKDGAKGSGKMFASIDEALLAYDKGLIDIQAPIFVRMTGTVYGESDRPVRMLSPDENGAPRMLLETTIGRIIFNNELLEPLRFRNRLIAKKGLREIIADCYKYYTNLNNLTEADLDTIRAMYGDRPRDDLARYFGSEMTASQADRIKTLGFRYATRGGMTIGVDDIEIPPKKQDILAEAEKRVTEVERQFRRGLITEEERYREIVEIWQNATKQTTEAVKQHLNPFGPVAMMVNSAARGNINQLSQMAGMRGLMSDPTGRIIELPIKSNFREGLSVLEYFVSTHGGRKGLADTALRTADAGYLTRRLIDVAQDNIVTIDDCGTDEGLWIYRADDREVLQDFEQRILGRLLAAPLVDPRTGEILANRNDEIDEALVRKCKELAIDAVYVRSPLACKADYGICRMCYGRNLATGKLVDIGEAVGIIAAQSIGEPGTQLTLRTFHTGGVASADDITQGLPRVQEIFEARTPKGKAILAEIDGIVELVREDEVRKIRVVATELYTDDHELPPHYEPVVADGAQVNEGDVLAQSNRADLNGEPIVARIAGVVRIGAGQISVINEEREVREVVAPHTARLAPGIENGARVVAGQHLTEGSADPQELLALQGREAVQRYLVNEAQKVYRSQGVDINDKHIEVIVRQMLRRVRIEEPGDTDYLPGELIDSTEFVRKNAEIISQGGEPATASTMLLGITKASLTTDSFLAAASFQETTRVLTEAAITGKVDYLRGLKENVVIGKLIPAGTGIEKRRQLAEEIIGELANVAPATSTAVVEQERPDREADEALRRRLRALIGGDGDDGERNNGDFDDQVGEDVVIPPDDDDQEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: IMPA3_CALJA
Sequence: MAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPAGGAAGPPAAADGGTVDLREMLAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGADDKMTSGDVLSNRKMFYLLKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILKEVTAPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPVLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPRIVVSRSHSGMVKQVALQTFGNQTTIIPAGGAGYKVLALLDVPDKSQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLSGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKMGH
What is the function of this protein?
Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate.  May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.  Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
What are the official names of this protein?
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase, Golgi-resident PAP phosphatase, gPAPP, 3'(2'), 5'-bisphosphate nucleotidase 2, Inositol monophosphatase domain-containing protein 1, Myo-inositol monophosphatase A3, Phosphoadenosine phosphate 3'-nucleotidase.
What is the protein family that this protein belongs to?
Belongs to the inositol monophosphatase superfamily.
What are the subcellular locations of this protein?
Golgi apparatus. Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Note=The catalytic core is predicted to reside within the Golgi lumen.
Protein: HEM6_ECOLU
Sequence: MKPDAHQVKQFLLNLQDTICQQLSAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRPELAGRSFEAMGISLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCQPFGEDVYPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTNAYLPIVERRKAMAYGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYHPEDGSPEAALSEFIKVRDWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBA_HAECO
Sequence: MREVISIHIGQAGVQIGNACWELYCLEHGIQPDGQMPSDKSLGGCDDSFSTFFSETGSGRHVPRAVMIDLEPTVIDEIRTGTYRSLFHPEQLITGKEDAANNYARGHYTIGKEIIDLTLDRIRRLADNCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKAKLEFSVYPAPQVSTAVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLDIERPSYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATFSPVISAEKAYHEQLSVAEITNMCFEPHNQMVKCDPRHGKYMAVCLLFRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVPRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSLEDNGEEGDEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TYSY_PSEFS
Sequence: MKQYLELLNDVVTNGLTKGDRTGTGTKAVFARQYRHNLADGFPLLTTKKLHFKSIANELIWMLSGNTNIKWLNENGVKIWDEWATEDGDLGPVYGEQWTAWPTKDGGTINQIDYMVHTLKTNPNSRRILFHGWNVEYLPDETKSPQENARNGKQALPPCHLLYQAFVHDGHLSMQLYIRSSDVFLGLPYNTAALALLTHMLAQQCDLIPHEIIVTTGDTHAYSNHMEQIRTQLARTPKKLPELVIKRKPASIYDYKFEDFEIVGYDADPSIKADVAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBIJ_MYCTU
Sequence: MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD
What is the function of this protein?
Methylates precorrin-2 at the C-20 position to produce precorrin-3A.
What are the official names of this protein?
Cobalamin biosynthesis protein CobIJ.
What is the protein family that this protein belongs to?
Belongs to the precorrin methyltransferase family.
Protein: RIBB_SHESR
Sequence: MNQSLLAPFGTAIERVEAGLEALRQGQGVLVVDDEDRENEGDLIFAAESLTNAQMAMLIRECSGIVCLCLPDEKVKALELPPMVENNSSQYGTAFTVSIEAKVGVTTGVSAADRVTTIKAAIADNAKPSDLARPGHVYPLRAQPGGVLTRRGHTEGTIDLMQLAGLKPAGVLCEVTNPDGTMARLPEIIAFGAAHNMPVLTIEDIVVYRKSLLANVG
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: INS2_CONIM
Sequence: MALTWPSSPPVLLTLLLSLLALQLCAVYGSYEHTCTLATRSRGAHPSGICGRNLARIVSVLCTPRGYVSNWFTKRSAPNKPAETFVDQNLRGVLLNKREALSYLRPREPRATRGTFGSQGITCECCFNQCTYYELLQYCN
What is the function of this protein?
This venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock.  Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin.  In vivo, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.
What are the official names of this protein?
Con-Ins Im2, Insulin 2.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NDK_PROA2
Sequence: MERTLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTKLTAQTAGEFYAVHSQRPFYGELVEFMSSGPCVPMILEKENAVADFRTLIGATDPAEAAEGTIRNLFADSKGENIIHGSDSAENAQIEAGFFFSTEEAVRVNN
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_AYWBP
Sequence: MIQRESRLVVADNSGAKEVLVIGILGGTRRSHVNIGDIVVVTVKSGSGTVKKHDVLKAVIVRTKKGLRRKNGSYIKFDDNAVVLLKEDLNIIGTRIFGPVVRELSDKKFSKIVSLAQLVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: CRCB_HAHCH
Sequence: MSVPHLVYVALGGALGAVSRYLIVAWVSNVAGAKFPWGTLAVNLLGSFLLGTAFVYVVEKLHGQPELRSLIMVGFLGALTTFSTFSLEAWSLMQSDQLLQGLAYILMSVILCLFAVSAGIALTRLIL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLGA_VARPS
Sequence: MRILQVSAELFPLLKTGGLADVAGALPLALMAAGQDARVLLPGFPAILAGVRELAPVAEFTAPWGPERFGLRAGRIAIDGAAAPITAYVIDAPVLYDRPGNPYEDATRQPYGDNHRRFALLGWAAAQLAQGLDPAWQPEVVHAHDWHAGLAPAYLHFAREAGLTRTGSVFTVHNLAYQGISAPWNFADLGLPAPAFHMNGLEYHGQVSFMKGGLYFADRLTTVSPTYAREIQTPEQGFGLDGLLRLRGGVLTGILNAVDDEVWNPATDSALVQGYHTPDGRHMAGKARCKAVLQHQLGLAERPDAPLFILVSRLTEQKGLHLVLGGLDTLLAEGGQLALLGSGEAGLEQAFRERAAAAPRAVSVTIGYNETLAHQLFGGGDVTLVPSLFEPCGLTQMYGLKYGSLPLVRRVGGLADTVVDCTLEDMASGHATGFVFDRFDAADYDRALRRAFALYQRAPDWRRVRGNAMRRPADWASAAGQYIEVYRQALESAGT
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: YCF4_MESVI
Sequence: MINFSTNSDLILRESVVGSRRISNYWWASVVLLGASGFLIVGISSYLQYDLVPFLSAKNIVFVPQGLVMCFYGSAGILLSIYLWLTIFWNVGEGYNEFDKVNGLVRIFRWGYPGKDRRINIVYDIKDIQAIRVEIKEGINPRRVIYLKIKGTRDMPLTRIGQPLTLAEIEEQAARLARFLQVNIEGI
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: KHSE_PROMA
Sequence: MIQPPIGKKVLVEVPSTTANLGPGFDCLGAALSLTNFFTIKRIDGDSERFELIMESTEGNHLRGGPENLFYRAAQRVWKAAEVEPFALEARVKLAVPPARGLGSSATAIVAGLVGANALINDPLSKEKLLELAIDIEGHPDNVVPSLLGGLCFTAKAASQRWRVVKCDWDDSIKAVVAIPSLRLSTSEARRVMPKTVPLGDAVMNLGSLTLLLNGLRTGRQDLITDGMHDRLHEPYRWKLIKGGAQVCEAAINAGAFGCAISGAGPSILALCKEDKGRNISQAMVKAWESEGVASRAPLLNLQTKGSTWYSNQSK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_BRUAB
Sequence: MPRYKLTVEYDGTPYVGWQRQENGHAVQGAIEQAFKKFCGEDLTLSAAGRTDAGVHATAQVAHVDLAKDWGAGKVRDAVNAHLVMADERISILNVEKTTDTFDARFSARARHYLYRIHNRRAPLAVDYQRAWWVQKQLDADAMHEAAQRLLGEHDFTTFRATQCQAKSPVKTLDRLDVTRNGDMVEMRVSARSFLHNQVRSFAGSLMEVGVGRWTADDLQAALEARDRKACGQVAPPYGLYLVGVDYAFPF
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: GI_EHV1D
Sequence: MAKLTGMFSAAILLSMAICSTAIIYRGEHMSMYLNASSEFAVYPTDQSLVLVGHLLFLDGQRLPTTNYSGLIELIHYNYSSVCYTVIQTISYESCPRVANNAFRSCLHKTSKHYHDYFRVNASVETNVLLNITKPQPTDSGAYILRVKLDHAPTADVFGVSAFVYDLKSKTVPDPMPTTQTVEPTTSYVSTPTYDYTDDVTTETESTSTSTQQAMTSTQTPSATWGTQLTTELPTNETVVIGQEALLCHWFQPSTRVPTLYLHLLGRTGNLPEDVLLVEDSEFLRTTSPAHRPSASPADGDDFKQTNSTSLKARNKIVAMVVIPTACVLMLLLVVVGAIINGAVRKHLLSCASRRIYRSGQGGASAAERRRLTCGPTLAASSESLADDTTSSPPTPKPSKKTKLETDPLMEQLNRKLEAIKEES
What is the function of this protein?
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions.  Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions.  Implicated in basolateral spread in polarized cells.  In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system.  Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.
What are the official names of this protein?
Envelope glycoprotein I, gI.
What is the protein family that this protein belongs to?
Belongs to the alphaherpesvirinae glycoprotein I family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass type I membrane protein. Host cell junction. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). The heterodimer gE/gI then redistribute to cell junctions to promote cell-cell spread later in the infection (By similarity).
Protein: UPP_CORGB
Sequence: MDITIVNHPLVASRLTLLRDERSDNAAFRAAANDLGAMLIYEASRDLEVEHFDTKTPVAMAEGTRLKQPPIIVPIIRAGLGMIDPALSMIPDAQVGFIGLARDEETHEPVPYLEALPQDLSNQPVFLVDPMLATGGSLLHAIRLLADRGATDITAICMVSAQPGVDALAESGLPVRLVTATIDPGLDENAYIVPGLGDAGDRLYGPRNIDL
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: MTFA_ECO57
Sequence: MIKWPWKVQESAHQTALPWQEALSIPLLTCLTEQEQSKLVTLAERFLQQKRLVPLQGFELDSLRSCRIALLFCLPVLELGLEWLDGFHEVLIYPAPFVVDDEWEDDIGLVHNQRIVQSGQSWQQGPIVLNWLDIQDSFDASGFNLIIHEVAHKLDTRNGDRASGVPFIPLREVAGWEHDLHAAMNNIQEEIELVGENAASIDAYAASDPAECFAVLSEYFFSAPELFAPRFPSLWQRFCQFYQQDPLQRLHHANDTDSFSATNVH
What is the function of this protein?
Involved in the regulation of ptsG expression by binding and inactivating Mlc.
What are the official names of this protein?
Protein MtfA, Mlc titration factor A.
What is the protein family that this protein belongs to?
Belongs to the MtfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_SHEAM
Sequence: MPRSLKKGPFIDLHLLKKVEKAVEAGDKKPIKTWSRRSMIIPQMIGLTIAVHNGRQHVPVFVTDEMIGHKLGEFSPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: RGYR_SULAC
Sequence: MQSLSDIPPSIYLFSCPNCGRSISTYRLLLGSVCNICLEEDKEYKNIGDLIKDIEKQGNLIKLKDIQRVLDDYESFVSVFRRLLGFPPFGPQKSWIYRLLSGESFAIIAPPGLGKTTFGLISSIYLYLRGKKSILVFPTKSLVRQAIDKLSSYIQNLAEIKENPPKVIYYYSGMSASERKEADEGLQSKTFDIFISTNRFLIDNIDQISSTSYQFLFVDDVDTALKSSKSAQAILKLLGFTPSDQDKIKESLKKYRENTQKNEQNEYIFEEIDKIRKDRLASKTVIFSSATLNRSNPILTSLVGFKPGSSVIYIRKVYDMYVKQPDKEQETFNLIKSLLHRLGDGGLIFVPVDKKQEYIKRLQSELSNEFNVAAITSTSATKIDDFANGEIDVLIGSATHYGILVRGLDLPWRVKYSIFVGIPKFKFRLGEKVNLLTLSRLLSLIALITKDQEVIYISRRVKDKIRRLSPAALTMLSVQAKEGKLEDSILLKAYDLLNKYLSNQNVLKRISEIGDFVLSPDNDILIPDYLTYVQASGRTSRIYAGDVTTGLSILLVDDFNLFRLLNKKLQYILDDIQWRELDVEKWTAGDVEIKNLISKINEERNEISKLKNEGNVAPALQKVKTVLLVVESPNKAKTISSFFSRPSIRQIGNMRVYETVLGDKVLMVTASGGHVYDLTTQDMGIYGVDIMKQNSSLVFIPIYNSIKKCENNHQFTDFFESNKCPRCMTTKVRYDSLKSINVLRNLAVEADEVLIGTDPDTEGEKIAWDLYLALRPYNSNIRRAEFHEVTRKAILQAINQPREFNVNLVKSQLVRRIEDRWIGFKLSSILQTRFWPEYCKSLSSNKQLNCNENKNLSAGRVQTPVLSWIVDRYTEYQRNKSRVYYGKIDQLQDIVIYVPKQDGVRKNSKIVVVFNEINQLEEEFGPLPPYTTDTLLSDSNNFFGLSAPETMRIAQDLFELGLITYHRTDSNRISNTGISVAENYLKDVLGDKYTNIFKPRSWGDGGAHEGIRPTKPIDVEQLRLLIEEGELELAKRLTNNHFKVYDIIFRRFISSQIIPLKVRKEIVKIELYGENKKEKINSNQNIIEVITGITLPGIDTEISKFAYVPVRNVSRSVAERLKELGRSIPTDFSIEISNSFIKSTVNLYTQADLVMEMKNKKIGRPSTYATIIGTILRRGYVLESLKTKKLIPTRLGVEVNKYLNENYGRFVSEDRTRKLLQLMDMVEAGQEKYEEVLKQVYEEINEIR
What is the function of this protein?
Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process.  It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue.  May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
What are the official names of this protein?
Reverse gyrase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
Protein: RPOZ_YERPA
Sequence: MARVTVQDAVEKIGNRFDLVLVAARRARQIQSGGKDALVPEENDKVTVIALREIEEGLITNQILDVRERQEQQEQQAAEIQAVTAIAEGRR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: LACD_LACLL
Sequence: MVLTEQKRKSLEKLSDKNGFISALAFDQRGALKRLMAQYQDTEPTVAQMEELKVLVADELTKYASSMLLDPEYGLPATKALDKEAGLLLAFEKTGYDTSSTKRLPDCLDVWSAKRIKEQGADAVKFLLYYDVDSSDELNQQKQAYIERVGSECVAEDIPFFLEILAYDEEISDAGSVEYAKVKPRKVIEAMKVFSDPRFNIDVLKVEVPVNVKYVEGFADGEVVYSKAEAADFFKAQEEATNLPYIYLSAGVSAKLFQETLQFAHDSGAKFNGVLCGRATWAGSVEPYIKEGEKAAREWLRTTGFENIDELNKVLVKTASPWTDKV
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase, D-tagatose-1,6-bisphosphate aldolase, Tagatose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: DB121_PANTR
Sequence: MKLLLLLLTVTLLLAQVTPVMKCWGKSGRCRTTCKESEVYYILCKTEAKCCVDPKYVPVKPKLTDRNTSLESTSAV
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
Beta-defensin 121, Defensin, beta 121.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL17_NITMU
Sequence: MRHHNGLRKLNRTSSHRSAMLRNMTNSLLRHEVIKTTLPKAKELRRVIEPMITLGKKPSLANRRLAFDRLRDRDMVGKLFSELGPRYQTRNGGYLRILKFGFRKGDNAPMALVELMDRPEQPATDTESKAG
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.