PharMolix/UniProtQA huggingface dataset:
Protein: RS3_BARQU
Sequence: MGQKINPIGLRLGVNRTWDSRWYADSGEYGRLLHEDLSIRLYVLEELKQAAISKVIIERPHKKCRVTIYSARPGLIIGKKGADIEKLRRKLSEMTNAETSLNIVEIHKPEIDATIIAQSIAQQLERRVAFRRAMKRAVQSAMRLGAEGIRINCSGRLGGAEIARMEWYREGRVPLHTLRSDVDYGTAEAKTAYGICGVKVWVFKGEILEYDPIASERRSVEIDHSGSSSNRRRENA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: YOM2_SCHPO
Sequence: MGTVVGETELNRLNNGLSSNNGSSADEGLEHWNPLKKIHSADSSRRRSTSSQLNQPSNYHMHSSLHEEVSVGSSIASPSSRIPDKAISQYYETSPPSSTSSLSSNNQLMNSSVILSPGQFLPDDANAYGPKASLPPSEMPSHFHPLWSKSASKDSNAFNDPSAIPNPSPLFSSAYATRINGSLRNDKWNRSSFSEALSSSRFSRPQVGQQQPLSSAFPFQPVKQPTEQPGSLHPFMQESKTSPFATRRPSLNTDHHGRPILLSPLNYQNSSLNPSTPSPFGGSPVMHPPVSNLSPRTPAVPMSSDGHLAPAFDFLNENPIWSKRFSISSIKYSAPSTSNASNIAPDSAPPASSQFSVPFNAAAENINDTPDSVLANSPTPRHLPYTWSRHSTSGPSRSTVLNPSTSRMSNYTGLESHLAQLSFKRRSNSATLPSLGSIRPFPISEHSPNINPLDEAAVEDEVKEEKSRFHLGHRRSSTADNGTLSSNVPLYPAYNSSPVQTRTSLFSSRLSKPSNPIVSSVSQANAPKNALHSMPSPTSLANLPSNLSDTQYKKLYNLYLVEFKAGRADVFYIDDNIKLSLNLNDYVVVDADRGQDLGRLIAQNLSQSEVASHIEKIPSDRNGQLQNLDGAILEGDTSQSLHPKRILRKAQPHEVDQLIQKTQDEAQALLVCQAKVRQRKLPMEVLDGEYQWDRKKLTFYYHAKQRIDFRELVRDLFKVYKTRIWMCAVSGTNMSSPASINASTNQFVL
What are the official names of this protein?
Uncharacterized protein PB7E8.02.
Protein: RPOC_STAA3
Sequence: MIDVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWECSCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLLLDMSPRALEEVIYFASYVVVDPGPTGLEKKTLLSEAEFRDYYDKYPGQFVAKMGAEGIKDLLEEIDLDEELKLLRDELESATGQRLTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKMYQCGLPKEMALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVTTAYNADFDGDQMAVHVPLSKEAQAEARMLMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVHASSFNNPTFTEEQNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRYFIDPTTLGEGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGFKFSSKAGITVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERYNAVVEIWTDAKDQIQGELMQSLDKTNPIFMMSDSGARGNASNFTQLAGMRGLMAAPSGKIIELPITSSFREGLTVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMIEPFIERIEGRYSKETIHHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARHGVCEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVAGSDITQGLPRIQEIFEARNPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVEIGQPVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQKVYRMQGVEIDDKHVEVMVRQMLRKVRIIEAGDTKLLPGSLVDIHNFTDANREAFKHRKRPATAKPVLLGITKASLETESFLSAASFQETTRVLTDAAIKGKRDDLLGLKENVIIGKLIPAGTGMRRYSDVKYEKTAKPVAEVESQTEVTE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: FER_STUST
Sequence: MTFVVTDNCIKCKYTDCVEVCPVDCFYEGPNFLVIHPDECIDCALCEPECPAQAIFSEDEVPEDQQEFIELNADLAEVWPNITEKKDALADAEEWDGVKDKLQYLER
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin 1.
Protein: LUXS_BACC1
Sequence: MPSVESFELDHTIVKAPYVRHCGVHNVGSDGIVNKFDIRFCQPNKQAMKPDVIHTLEHLLAFNLRKYIDRYPHFDIIDISPMGCQTGYYLVVSGTPTVREIIDLLELTLKDAVQITEIPAANETQCGQAKLHDLEGAKRLMNFWLSQDKDELEKVFG
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: EV165_ASFK5
Sequence: MYLVLLIAVILFIIVILMIFLISGLFYPEQEPALPISPPKKKCKTDTDCKDKGHHCVGGICTNMSCLDAIKYDIKDIKLDPNIRSCNYTPKFYKFSNTTADLQSPFGKTRIDDAELYDPHSGEDFCQRLCLDRKDCIGWEFDQYYAKTTGECYFYIDPHPALKSKNDAVLAIARKVS
What are the official names of this protein?
Putative membrane protein 165.
What is the protein family that this protein belongs to?
Belongs to the asfivirus envelope protein p22 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein.
Protein: DAPB_VIBPA
Sequence: MVRIAIAGAAGRMGRNLVKASHINPDASVTAGSERPESSLVGVDIGELCGEGKFDVFLTDDLEKEVDNFDVVIDFTVPVSTLANLELCKQHGKSIVIGTTGFSEEERALIDAVAKHVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDVEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHSKPAGFYTMTDVLGLNEL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRC6_ASHGO
Sequence: MVAEGLCQCYIRRMSTGGPHGAAPDRSCLARDTEGRSPCKNCQGCTQGAADPIPIRILMADSDVEQAPSVSVLPRNKILILAPAGKAYQAEVIRDLFNIEASESDRIVRDVKWSNKYYEVDLDLYIDSYESLQTWGAEFCSDECADLRDVVAGIFLVFEETEDAETFQQLIEDCHFTDERVLVACDLSSAEHPASLERALEVHDVALVRWRERGTNELGEQQGRERVRELLDIHPWSERMLRMHASTAAALAELDPLQADIPLDSVVTRIKQARERYLEITDVHAADEYAARIAHELTEQLLPE
What is the function of this protein?
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
What are the official names of this protein?
Increased recombination centers protein 6.
What is the protein family that this protein belongs to?
Belongs to the IRC6 family.
Protein: NADE_HELPJ
Sequence: MQKDYQKLIVYLCDFLEKEVQKKGFKKVVYGLSGGLDSAVVGVLCQKVFKENAHALLMPSSVSMPESRTDALNLCEKFSIPYTEYSIAPYDKIFGSHFKDASLTRKGNFCARLRMAFLYDYSLKSDSLVIGTSNKSERMLGYGTLFGDLACAINPIGELFKTEVYELAYYLNIPKKILNKPPSADLFVGQSDEKDLGYPYSVIDPLLKDIEALFQTKPIHLETLIQLGYAEILVKNIISRIQKNAFKLELPTIAKRFNPE
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: RS10_ACAM1
Sequence: MTTLQQQKIRIRLKAFDHRLLDTSCDKIVETAKRTNASPVGPIPLPTRRRIYCVLRSPHVDKDSREHFETRTHRRIVDIYQPSPKTIDALMKLDLPAGVDIEVKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: YN56_CAEEL
Sequence: MIPPPPNTSSLTCTPEEESENYKAVENMFATLYFFLPFSAFAALLANVIYLIVVTVGIRKGKLPLKRYALTINRTCADIFTILVGTYFYMKQKMDRCDSHICLPVETDMSRYVLQVVFVLNYWCVSLSYSGIAVLTNYAVRAPLQYKVNLTSMKVAKYILMGWIALLFCFLLCILLVHQGELDYNSNSVIHLFLDDFDSDEFIGEWLVDLCNHIKSHPGSRSLIVTILPPIVFYCISVVSYVFIIHLLFSRRKVSSYHRHWGSMLRLGIHLILFAGTCALTGTAYLGSFSIGDICENYKTNEPMCLDPVVLYMWNTAAALIGWICRMVIDATVDTFNDDVLRRTFFNSIRHRLLTGPTNTANDTKLILNQIEISCNKTSTGPSRKTESVQMESLMKIKPSRSRRLKINAQKSATIIEENIA
What are the official names of this protein?
Uncharacterized protein ZC21.6.
Protein: HTIB_MANSE
Sequence: EDICSLPPEVGPCRAGFLKFAYYSELNKCKLFTYGGCQGNENNFETLQACXQA
What is the function of this protein?
Inhibits trypsin.
What are the official names of this protein?
Hemolymph trypsin inhibitor B, BPI-type.
Protein: HIS5_SYNJA
Sequence: MKAVRLAVIDYDAGNLHSACKGLERAGAEVQLVTEPAGLAAFDGLVLPGDGAFDPAMQQLRARGFGEAIRQAIERQQPFLGICIGLQVLFEDSEEGTEPGLGIVPGRVQRFRPEPGLRIPHMGWNQLHLTQPDSPLWAGIPEQSWVYFVHSYHAVPKDPSWVVATTQHGSQTCVAAIARGTLFATQFHPEKSGPVGLKILQNFVEFVARRLPAAGA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_MARN8
Sequence: MTKIANIKAREVLDSRGNPTVEADVILEDGTLGRACAPSGASTGSREALELRDGDASRYLGKGVRKAVEAINGQIRDALLGKDAADQRSLDQIMIDLDGTENKANLGANAILAVSLAAAKAAAVSLGKPLYEHIADVNGTSGKFSMPVPMMNILNGGEHADNNVDIQEFMVQPVSVNSFGEALRVGAEIFHSLKKVLKAQGLNTAVGDEGGFAPNLPSNEAALAAIKEAVEKAGYELGKDVTLALDCASSEFYKDGQYQLSGEGKSFDSEGFADYLSGLCDRYPIVSIEDGMDESDWDGWKVLTDKLGSKVQLVGDDLFVTNTKILKQGIEKGIGNSILIKFNQIGSLTETLDAIKMAQDAGYTAVISHRSGETEDTTIADLAVATCAGQIKTGSLCRSDRVAKYNQLLRIEEALEGKAPYRGLSEIKGQG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RUVB_AZOC5
Sequence: MVAQGGMAPRLMTADSRPEDDADATLRPQRLADFVGQAQARANLEVFIQAARARGEALDHVLFVGPPGLGKTTLAQIMAREMGVGFRSTSGPVIAKAGDLAAILTNLEERDVLFIDEIHRLAPQVEEILYPAMEDYELDLVIGEGPAARSVKISLPKFTLVGATTRSGLLTTPLRDRFGIPVRLVFYTLEELEYIVTRGARLLGIGIVPEGAREIARRARGTPRIAGRLLRRVRDFAQFAGAEAIDRAIADRALMALDVDAMGLDTMDRRYLTVIAQHYGGGPVGVETLAAALSEPRDAIEEIVEPYLVQQGFVQRTPRGRMLTSGAFRHLGLAEPQRPPSALPLFDEGD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: AMP2_SCYSE
Sequence: HSPGGA
What is the function of this protein?
Has antibacterial activity against the Gram-positive bacterium B. flexus and the Gram-negative bacteria E. coli and V. harveyi along with two other Vibrio species.
What are the official names of this protein?
Antimicrobial protein 2.
What are the subcellular locations of this protein?
Secreted.
Protein: ABI1_MOUSE
Sequence: MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVAAQFSAQPHVNGGPLYSQNSISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
What is the function of this protein?
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2.  In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts.  May play a role in regulation EGF-induced Erk pathway activation.  Involved in cytoskeletal reorganization and EGFR signaling.  Together with EPS8 participates in transduction of signals from Ras to Rac.  In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex.  Regulates ABL1/c-Abl-mediated phosphorylation of ENAH.  Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.  In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
What are the official names of this protein?
Abl interactor 1, Abelson interactor 1, Abi-1, Ablphilin-1, Eps8 SH3 domain-binding protein, Eps8-binding protein, Spectrin SH3 domain-binding protein 1, e3B1.
What is the protein family that this protein belongs to?
Belongs to the ABI family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Postsynaptic density. Cytoplasm, cytoskeleton. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity).
Protein: HOX4_ORYSI
Sequence: MKRPGGAGGGGGSPSLVTMANSSDDGYGGVGMEAEGDVEEEMMACGGGGEKKRRLSVEQVRALERSFEVENKLEPERKARLARDLGLQPRQVAVWFQNRRARWKTKQLERDYAALRHSYDSLRLDHDALRRDKDALLAEIKELKAKLGDEEAAASFTSVKEEPAASDGPPAAGFGSSDSDSSAVLNDVDAAGAAPAATDALAPEACTFLGAPPAAGAGAGAAAAASHEEVFFHGNFLKVEEDETGFLDDDEPCGGFFADDQPPPLSSWWAEPTEHWN
What is the function of this protein?
Probable transcription activator that binds to the DNA sequence 5'-CAAT[AT]ATTG-3'.  May be involved in the regulation of gibberellin signaling.
What are the official names of this protein?
Homeobox-leucine zipper protein HOX4, HD-ZIP protein HOX4, Homeodomain transcription factor HOX4, OsHox4.
What is the protein family that this protein belongs to?
Belongs to the HD-ZIP homeobox family. Class I subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: KITH_STRP6
Sequence: MAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSALDTRDGFGIVSSRIGMRREAIPISNDIDIFTFIAQLEEKPYCVLIDESQFLSKQNVYDLARVVDELNVPVMAFGLKNDFQNNLFEGSKHLLLLADKIDEIKTICQYCSKKATMVLRTENGKPVYEGDQIQIGGNETYIPVCRKHYFNPEI
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UEVLD_MOUSE
Sequence: MEFDCEGVRRLLGKYKFRDLTVEELKNVSVSFPHFRYSVDTYVFKDTSQKDLLNFTGTIPVMYQGKTYNIPIRFWILDSHPFAPPICFLKPTANMEISVGKHVDAKGRIYLPYLQNWSHPKSAIVGLIKEMIAKFQEELPLYSIPSSNEAQQVDLLAYITKITEGVSDINSRGWTNHENKILNKITVVGSGDLGIACTLAISAKGIADKLLLLDLSDGMSQGTMDLDIFNLPNVEISKDLSASAHSKVVIFTANSLGGSESYLHAVQSNVDMFRALVPALGHYSQHAVLLVASQPVEIMSYVTWKLSTFPATRVVGIGCNLDSQRLQYIITSVLKVQTSGKEVWVVGEQGENKVCSWSGRDGVLSPSSQAQLSSRAMELLKVKGQRSWSVGLSVADLVDTIINNKRKVHSVSTLAKGYYGLDNEVFLSLPCILGTGGVSEVIKTKAGEDTVTGTLQASASSIHALQQQLEL
What is the function of this protein?
Possible negative regulator of polyubiquitination.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 variant 3, UEV-3, EV and lactate/malate dehydrogenase domain-containing protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the LDH/MDH superfamily.
Protein: HISX_LEGPL
Sequence: MLTIKNWQLLSENDKKLCLSRPRQSSAIKENVLEIINQVQLSGDKALYDLTKQFDRVNLQYLQVPQETIEQANIPQNALNAITQAIGTISSYHQSLLPENTEISTASGITIRNVYRPIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDAEGEINEHILVAARLCGIDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDANGAAIDMPAGPSEVMILADTEANSEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEFIKQSLANSRIIICSNQSEQLDIINSYAPEHLIINRKNPESWVEKIVAAGTVFLGSWAAETMGDYVTGSNHVLPTNGFARNHSGLSTLDFMTRFTVQAINQEAICNLGPAAMALAELEGLDAHANAVQIRLNTLGD
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: URIC1_SOYBN
Sequence: MAQQEVVEGFKFEQRHGKERVRVARVWKTRQGQHFIVEWRVGITLFSDCVNSYLRDDNSDIVATDTMKNTVYAKAKECSDILSAEEFAILLAKHFVSFYQKVTGAIVNIVEKPWERVTVDGQPHEHGFKLGSEKHTTEAIVQKSGSLQLTSGIEGLSVLKTTQSGFVNFIRDKYTALPDTRERMVATEVTALWRYSYESLYSLPQKPLYFTEKYQEVKKVLADTFFGPPKGGVYSPSVQNTLYLMAKATLNRFPDIAYVSLKLPNLHFIPVNISNQDGPIVKFEDDVYLPTDEPHGSIQASLSRLWSKL
What is the function of this protein?
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
What are the official names of this protein?
Uricase-2 isozyme 1, Nodule-specific uricase, Nodulin 35, N-35, Urate oxidase, Uricase II isozyme 1.
What is the protein family that this protein belongs to?
Belongs to the uricase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: FWCH1_HUMAN
Sequence: MPLPEPSEQEGESVKAGQEPSPKPGTDVIPAAPRKPREFSKLVLLTASDQDEDGVGSKPQEVHCVLSLEMAGPATLASTLQILPVEEQGGVVQPALEMPEQKCSKLDAAAPQSLEFLRTPFGGRLLVLESFLYKQEKAVGDKVYWKCRQHAELGCRGRAITRGLRATVMRGHCHAPDEQGLEARRQREKLPSLALPEGLGEPQGPEGPGGRVEEPLEGVGPWQCPEEPEPTPGLVLSKPALEEEEAPRALSLLSLPPKKRSILGLGQARPLEFLRTCYGGSFLVHESFLYKREKAVGDKVYWTCRDHALHGCRSRAITQGQRVTVMRGHCHQPDMEGLEARRQQEKAVETLQAGQDGPGSQVDTLLRGVDSLLYRRGPGPLTLTRPRPRKRAKVEDQELPTQPEAPDEHQDMDADPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVTVMRGHCHPPDLGGLEALRQREKRPNTAQRGSPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVMVMRRHCHPPDLGGLEALRQREHFPNLAQWDSPDPLRPLEFLRTSLGGRFLVHESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQGHRIMVMRSHCHQPDLAGLEALRQRERLPTTAQQEDPEKIQVQLCFKTCSPESQQIYGDIKDVRLDGESQ
What is the function of this protein?
Transcription cofactor (PubMed:30097457).  Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457).  May play a role in DNA-damage response signaling (PubMed:33924684).  Binds specifically to DNA sequences at peri-centromeric chromatin loci.
What are the official names of this protein?
FLYWCH-type zinc finger-containing protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y708_SYNJA
Sequence: MPKRTSLQNMGEAGEACVRQYLEEQGWQILAQQWRCRWGELDLVASRAGELIFVEVKTRSGQGWDQKGLLAVGIQKQQRLIRAAQAFLSQHPDLAELACRFDVALVEQRPGKEGVSYALADYLQGAFELWE
What are the official names of this protein?
UPF0102 protein CYA_0708.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: END3_MYCLE
Sequence: MARRWSGETRLGLVRRARRMNRALAQAFPHVYCELDFTSPLELTVATILSAQSTDKRVNLTTPAVFARYRSALDYMQADRAELENFIRPTGFFRNKAASLIRLGQALVERFDGEVPSTMVDLFTLPGVGRKTANVILGNAFGIPGITVDTHFGRLVRRWRWTAEEDPVKVEHAVGELIERDQWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSFGLGPTEPLLAAPLVQGPEAGHLLALAGL
What is the function of this protein?
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity.  The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site.  The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
What are the official names of this protein?
Endonuclease III, DNA-(apurinic or apyrimidinic site) lyase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
Protein: FIS_ECO55
Sequence: MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN
What is the function of this protein?
Activates ribosomal RNA transcription.  Plays a direct role in upstream activation of rRNA promoters.
What are the official names of this protein?
DNA-binding protein Fis.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Fis family.
Protein: SEPT8_BOVIN
Sequence: MAATDLERFSNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEECVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRLHQEEKRKVEEKRRELEEETNAFNRRKAAVEALQSQALHATSQQPLRKDKDKKKASGWSSIYSVTIP
What is the function of this protein?
Filament-forming cytoskeletal GTPase (By similarity).  May play a role in platelet secretion (By similarity).  Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).
What are the official names of this protein?
Septin-8.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Synapse. Cell projection, axon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Presynapse. Note=Expressed in axons of immature neurons, localizes to synapses in mature neurons.
Protein: CAMP_MACTO
Sequence: MKTQRDSPSLGRWSLVLLLLGLVMPLAIVAQVLSYQEAVLRAIDGINQRSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQKSPEDCDFKEDGLVKRCVGTVILNQARDSFDISCDKDNRRSARLGNFFRKVKEKIGGGLKKVGQKIKDFLGNLVPRTAS
What is the function of this protein?
Exhibits antimicrobial activity against E. coli and B. megaterium (in vitro).
What are the official names of this protein?
Cathelicidin antimicrobial peptide.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TET5A_MOUSE
Sequence: MHQRYFWTDQGQVAFGGHYMAEGEGYFAMAEDELTGGPYIPLGGDFGGGGSSFGDRCSDYCESPTAHCNVLNWEQVQRLDGILSETIPIHGRGNFPTLELQPSLIVKVVRRRLEEKGIGVRDVRLNGSAASHVLHQDSGLGYKDLDLIFCADLRGEEEFQTVKDVVLDCLLDFLPEGVNKEKITPLTLKEAYVQKMVKVCNDSDRWSLISLSNNSGKNVELKFVDSLRRQFEFSVDSFQIKLDSLLLFYECSENPMTETFHPTIIGESVYGDFHEAFDHLCNKIIATRNPEEIRGGGLLKYCNLLVRGFRPASEEIKTLQRYMCSRFFIDFSDIGEQQRKLESYLQNHFVGLEDRKYDYLMTLHGVVNESTVCLMGHERRQTLNLITMLAIRVLADQNVIPNVANVTCYYQPAPYVADANFSNYYIAQVQPVFTCQQQTYSTWLPCN
What is the function of this protein?
Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation (PubMed:33882302).  Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (PubMed:33882302, PubMed:26803617).
What are the official names of this protein?
Terminal nucleotidyltransferase 5A.
What is the protein family that this protein belongs to?
Belongs to the TENT family.
What are the subcellular locations of this protein?
Cytoplasm.