PharMolix/UniProtQA huggingface dataset:
Protein: RS3A_METM5
Sequence: MARMKARSAKGKRVAKDTWKSKVWYDIYTPQSFGGDVIGQTPANDPATLIGRISEISLRDLTNEHSKHMTRMYFKVDGVSGNNATSQFVGHDTTREYLKSQVRRRRSKINAIVDVRTKDGFKVRVKALVLTAVRARDHHKTEIRINMEQIIRHMAKETAFAEFVHAMLMGGLGSKIYGDCKKMFPLKRVEIFKSEVLEFGKAVEAPVEEPAAEEVAEAPAAETQE
What are the official names of this protein?
30S ribosomal protein S3Ae, Ribosomal protein S1e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
Protein: YRAN_SALSV
Sequence: MAQIPARGDCSRQLTRKQAGDAWEAAARRWLESKGLRFIAANVRERGGEIDLIMRDGKTTVFVEVRYRRSGLYGGAAASVTRSKQHKLLHTARLWLARQNGSFDTVDCRFDVLAFTGNEIEWFRDAFNDHS
What are the official names of this protein?
UPF0102 protein YraN.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: MURB_TRIL1
Sequence: MHAGLEHIRDWFKGELLFHEPLARHVSLKVGGPVDLLATPDSREELQQLVTLLDQQQIPRFVLGGGFNLLPSDVGYRGCAISLKQINRLQLDDTVVAIEAGASNQSLARAVAELGLSGIEFLIGIPGSVGGAVRMNAGAHGSDIFSVVKTVTLLDQGQFRELPREQLTYGYRCFEIPDNSVIVAVTLQLSEDSLQAVRSRMEEQLGLRWATQNVKFPNAGSFFKNPPGESAWRLIDQAGLRGFSIGNAQVSEVHTNFLINRGNATAADFRALAAAVKERVKATCGIELEEEVQLLDSGECGQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_CHRVO
Sequence: MRVSANLKSVRLSAQKCRLVADLVRGKSVDQALNILAFSPKKGAVIIKKVLESAIANAEHNEGADIDTLRVTSIFVDKGASLKRFTARAKGRGNRIEKQTCHISLTVGN
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: MATK_ROSFO
Sequence: MEEFQGYLELDRSQQHDFLYPLIFREYIYALAHDRGLNRSVLLDNVSYDKKSSLLIIKRLISRMYQQNHFIISVNDSNQNKFFGYNKNLYSQMISEGFAVIVEIPFSLRLVSSLEETETVKSYNLRSIHSIFPFFEDKFPHLNYASDVLIPYPIHLEILVQTLRYCVKDPSSLHLLRLFLHEYYNWNTLITPKKSIFAKSNQRLFLLLYNSYVCEYESILLFLRNQSNHLRLTSSGILFERIRFYEKIKYPVEEVFANDFPATLWFFKDPFIQYVRYQGKSILASKDTPLLMNKWKYYLVHFWQCHFYVWSQPGRIHINQLSKHSFDFLGYLSSIRPNISVVRSQLLENSFLMDNAMKKLDTLFPIIPMIGSLAKVKFCNTSGHPISKSSWADSSDSDIIDRFVRIGENLSHYYSGSSKKKSLYRIKYILRLSCVKTLARKHKSTVRTFLKRLGPKLLDEFFTEEEQIFSLLFPRTSSTLKRFYRGRIWYLDILCINDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL19_STRPG
Sequence: MNPLIQSLTEGQLRSDIPNFRPGDTVRVHAKVVEGTRERIQIFEGVVISRKGQGISEMYTVRKISGGIGVERTFPIHTPRVDKIEVIRHGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ISPF_COREF
Sequence: MRQNRRFLRCQVTEQIIPRVGIASDAHQIEAGKPCWIACLLFDGVDGCEGHSDGDVVAHAIVDALLSASGLGDLGSFVGVGRPEYDGVSGTQLLIEVRELLITRGFTIGNVAAQLVGQTPKFGPRREEAQQVISDILGAPCFLSATTTDHMGFTGRGEGRAALATAVVWTG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: YEJL_ECODH
Sequence: MPQISRYSDEQVEQLLAELLNVLEKHKAPTDLSLMVLGNMVTNLINTSIAPAQRQAIANSFARALQSSINEDKAH
What are the official names of this protein?
UPF0352 protein YejL.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: TCAF1_HUMAN
Sequence: MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLVVVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKDSLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAGIYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLVHGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGKVVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVGAQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAEFQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRENPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGTRYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLDKPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGPWGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQISVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCNLWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAFGWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSLAYLPEWKENIMKLYLLTQMPH
What is the function of this protein?
Positively regulates the plasma membrane cation channel TRPM8 activity.  Involved in the recruitment of TRPM8 to the cell surface.  Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.
What are the official names of this protein?
TRPM8 channel-associated factor 1, TRP channel-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the TCAF family.
What are the subcellular locations of this protein?
Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane.
Protein: HMD_METM5
Sequence: MKVAILGAGCYRTHAASGITNFSRAAQVAKEVGIPEITMTHSTITMGAELLHLIPEITEVVVSDPCFAEEPGIVVLDQFDYKTVMEAHLAGDAEKVMPEIREAVKAKAKETPKPPKGCIHFVHPETIGLKVTASDVEAVKNADIVITWLPKGGSQPAIIEKFVGAIKKGAIVTHACTIPTPKFAKIFKDMGRDDLNIIAYHPGAVPEMKGQAFLSEGLADAEKVEEFYCMAKTARGEAFKMPANLISPVCDMGSAVTAPVYAGILAYRDAVTQILGAPADFAQMMADEAITQLLELMRSEGIKNMEDKLNPKALTGTADSMCFGPLADILPTSLKVLEKHTNENKCECSCSIKP
What is the function of this protein?
Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
What are the official names of this protein?
5,10-methenyltetrahydromethanopterin hydrogenase, H(2)-dependent methylene-H(4)MPT dehydrogenase, H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase, N(5),N(10)-methenyltetrahydromethanopterin hydrogenase.
What is the protein family that this protein belongs to?
Belongs to the HMD family.
Protein: PKP2_HUMAN
Sequence: MAAPGAPAEYGYIRTVLGQQILGQLDSSSLALPSEAKLKLAGSSGRGGQTVKSLRIQEQVQQTLARKGRSSVGNGNLHRTSSVPEYVYNLHLVENDFVGGRSPVPKTYDMLKAGTTATYEGRWGRGTAQYSSQKSVEERSLRHPLRRLEISPDSSPERAHYTHSDYQYSQRSQAGHTLHHQESRRAALLVPPRYARSEIVGVSRAGTTSRQRHFDTYHRQYQHGSVSDTVFDSIPANPALLTYPRPGTSRSMGNLLEKENYLTAGLTVGQVRPLVPLQPVTQNRASRSSWHQSSFHSTRTLREAGPSVAVDSSGRRAHLTVGQAAAGGSGNLLTERSTFTDSQLGNADMEMTLERAVSMLEADHMLPSRISAAATFIQHECFQKSEARKRVNQLRGILKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITDHTVNLRSRNGWPGAVAHACNPSTLGGQGGRITRSGVRDQPDQHGLLWNLSSNDKLKNLMITEALLTLTENIIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTDNNKSIGCFGSRSRKVKEQYQDVPMPEEKSNPKGVEWLWHSIVIRMYLSLIAKSVRNYTQEASLGALQNLTAGSGPMPTSVAQTVVQKESGLQHTRKMLHVGDPSVKKTAISLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNIIQNSYQNARDLLNTGGIQKIMAISAGDAYASNKASKAASVLLYSLWAHTELHHAYKKAQFKKTDFVNSRTAKAYHSLKD
What is the function of this protein?
Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246).  Required to maintain gingival epithelial barrier function (PubMed:34368962).  Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes (By similarity).  Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity).  Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity).  Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity).  May play a role in junctional plaques (PubMed:22781308).  Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297).  Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297).
What are the official names of this protein?
Plakophilin-2.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.
Protein: DNAK_NOVAD
Sequence: MAKVIGIDLGTTNSCVAVMDGGTPKVIENSEGARTTPSIVAFTKDGERLIGQPAKRQAVTNPDNTIFAVKRLIGRRFDDPMTQKDTELVPYTITKGKNGDAWVKAGGQDYSPSQISAFTLQKMKETAEAYLGETVTQAVITVPAYFNDAQRQATKDAGQIAGLEVLRIINEPTAAALAYGLDKQDGKTIAVYDLGGGTFDISILEIGDGVFEVKSTNGDTFLGGEDFDTAVVEYLADKFKAKEGMDLKTDKLALQRLKEAAEKAKIELSSAQTTEINLPFITARMEGGATTPLHLVETVTRADLEKLVAGLIQRTLDPCKKALADAGISAKEIDDVVLVGGMTRMPKVREVVKDFFGKEPHTGVNPDEVVAMGAAIQAGVLQGDVKDVLLLDVTPLSLGIETLGGIMTKMIDRNTTIPTKKSQVYSTAEDNQQAVTIRVFQGEREMAQDNKLLGQFDLVGIPPARRGVPQIEVTFDIDANGIVNVSAKDKGTGKEQQIRIQASGGLSDADIDQMVRDAEKFAEEDKKRRAAAEAKNNAESLIHATERQLEENGDKVDAGLKAEIEAAIAEAKTAVESGDIDAMNAKAQALTDKAMKMGQAIYEKEQATAASPGAEAPKADDDVVDAEFSEVDENK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: METN1_BURP1
Sequence: MIEIRNLSQRFEGPRGWIEALHNVNLTIPQGEVFGIIGRSGAGKSTLVRTINLLTRPSEGSVFVGGRDLTQLSAAELRGARRDIGMIFQHFNLLSSRTVFDNVALPLELAGVKRAQIEATVLPLLDLVGLAAQKDRYPAQISGGQKQRVGIARALASKPKVLLSDEATSALDPETTRAILDLLRRINRELGLTIVLITHQMEVIKDVCDRVAVLDAGRVVEEGNVIDVFMRPHHEVTRALIGDVIAQELPPAMKARVAERLKTGSGHLLRLAFTGSGVDQPILSETIRRYELDFNILHGQIDEIQGRAFGSLAVLATGEPGKVGQAFAYLREQGVVVEELSYVE
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RR2_ORYSA
Sequence: MTRRYWNINLKEMIEAGVHFGHGIKKWNPKMAPYISAKRKGTHITNLARTTRFLSEACDLVFDAASQGKSFLIVGTKKRAADLVASAAIRARCHYVNKKWFSGMLTNWSITKTRLSQFRDLRAEEKMEKFHHLPKRDVAILKRKLSTLQRYLGGIKYMTRLPDIVIVLDQQKEYIALRECAILGIPTISLADTNCDPDLANISIPANDDTMTSIRLILNKLVFAICEGRSLYIRNH
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: APCE_SYNP2
Sequence: MTIKASGGSSLARPQLYQTVPLSNISQAEQQDRYLESGELTALKTFYDSGLKRLAIAQAIKLSSQLIVSRAANRIFAGGSPLAYLDQPETDTDDSDLGVSMAVGDASGATGIFGGVKNLFLGSGGGKIPAGFRPISVSRYGPRNMTKSLRDMAWFLRYTTYAIVAGDPSILVVNTRGLKEVIENACSIPATIVAIQEMKAASLDLFRGDREAQETVVQYFDVLITEMQTQVPNDKLRQRPSIDAQGLQLPQSYFNAAEKRQKFVMKPGLSALEKNSVVKAAYRQIFERDITRAYSQSISYLESQVKSGDISMKEFVRRLAKSPLYRKQFFEPFINSRALELAFRHILGRGPSSREEVQEYFAIVSSGGLAALVDALVDSQEYADYFGEETVPYLRGLGQEAQECRNWGMQQDLFKYSAPFRKVPQFITTFASYNQPLPDQHVYGSGNDALEIQFGAIFPKATRSPSASPAPFNKDTRRILIHRGPGINNQLGNPRARATQPGSLGAKVFRLNNELPSGKTTNVSFSESATQKVIEAAYRQVFGRMVYAGQRQKVAEIKLENGEITLREFIRALAKSDVFRNTYWSSLYVTKAVEYIHRRLLGRPTYGRQEINSYFDTCAKKGFYALVDAIIDSKEYEEAFGEDTVPYERYLTPGGYSLRQTRPGALREDVGVKVKVEKTARFIELGTSSTKNLPVTDVDARLKQGVNIQRQQTKAFKLTDTFNKVELKTAIAAAYRQIFERDIEPYIVDAQFTALESKLGNREINMKEFIEGLGCSELYQKEFYTPYPNTKVIEMGTKHFLGRAPLDQQEIRKYNQILASQGLKAFIGAMVNSMEYLDNFGEDTVPFRRFPTLPAANFPNTERLYNQLTKQNRDLVVPSFEPAVKR
What is the function of this protein?
This protein is postulated to act both as terminal energy acceptor (by its phycobilin-like domains) and as a linker polypeptide (by its repeats and arms) that stabilizes the phycobilisome core architecture (By similarity).  Has intrinsic bilin lyase activity.
What are the official names of this protein?
Phycobiliprotein ApcE, Phycobilisome core-membrane linker phycobiliprotein ApcE.
What is the protein family that this protein belongs to?
Belongs to the phycobilisome linker protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Anchors the phycobilisome perpendicularly to the cytoplasmic surface of the thylakoid membrane.
Protein: C7342_ORYSJ
Sequence: MEEDGGGGAGWGWATWRVAAVAAAAAVWVTMHVAARMADALWWRPRRLEAHFAAQGVRGPPYRFLLGSVREMVALMAEASSKPMSPPTSHNALPRVLAFYHYWRKIYGHRFLIWFGPTPRLTVAEPELIREIFLTRADAFDRYEAHPVVRQLEGDGLVSLHGDKWALHRRVLTDAFYPDNLNRLIPHVGKSVAALAAKWGAMAEAGGSGEVEVDVAEWFQAVTEEAITRATFGRSYDDGRVVFAMQGQLMAFASEAFRKVLVPGYRFLPTKKNRLSWRLDREIRRSLMRLIGRRSDEAEQGEKADDGSFRDLLGLMINAGAAAATRGNAGGEKNSPAAAIPVEDMLEECKTFFFAGKQTTTNLLTWATVLLAMHPDWQERARREVFDVCGAGELPSKEHLPKLKTLGMIMNETLRLYPPAVATIRRAKVDVQLSDGCMIPRDMELLVPIMAIHHDTRYWGPDASQFNPARFANGASKAAKHPLAFIPFGLGSRMCVGQNLARLEAKLTMAILLQRFEIRTSPNYVHAPTVLMLLYPQYGAPLIFRPLSSHPPDSTGP
What is the function of this protein?
Cytochrome P450 involved in brassinosteroids (BRs) inactivation and regulation of BRs homeostasis.  Is a multifunctional and multisubstrate enzyme that controls the endogenous bioactive BR content both by direct inactivation of castasterone (CS) and by decreasing the levels of BR precursors.  Catalyzes the oxidation of carbon 22 hydroxylated BR intermediates to produce C26 oxidized metabolites.
What are the official names of this protein?
Cytochrome P450 734A2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RS20_EXIS2
Sequence: MANIKSAIKRVKTAEKRRVANVQRKSSMRSAIKAVETFATEGNKEQALVAFNTASKKIDKAAAKGLIHSNKAGRDKSRLARLVNAL
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: K1PF_RHOCA
Sequence: MTLRIATVSLNSAVDQTVTVPGFTADAVNRVAASRIDAGGKGVNVASFLAHVGHGVAVTGLLGAENAALFARHFAATGLVDACQRLPGATRTNVKIVDPLQDQVTDLNFPGIAAGPADLDAVAATLTELLAQGLDWVALCGSLPAGIGAEAYAELAALARKGGARVALDTSGPALGLALAARPDIVKPNVAELGAHLGRTLTGLESVREAARDLAASGVGLVAVSMGAGGAVLVRGAEAVLAIPPATPIASTVGAGDAMVAGLIHAATLGLDLAETARLATAFSLGALGEIGPHLPPPERLAALARTVTVKTLPPV
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.
What are the official names of this protein?
1-phosphofructokinase, Fructose 1-phosphate kinase, Fru1PK.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: RL20_CHLFF
Sequence: MVRATGSVASRRRRKRILKQAKGFWGDRKGHIRQSRSSVMRAMAFNYMHRKDRKGDFRSLWIARLNVASRINGLSYSRLINGLKCAGIELNRKMLSEMAIHNPQGFAEVANQAKKALEATV
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NEP_I76A6
Sequence: MDSNTVSSFQDILLRMSKMQLGSSSEDLNGMITQFESLKLYRDSLGEAVMRMGDLHLLQNRNGKWREQLGQKFEEIRWLIEEVRHRLKTTENSFEQITFMQALQLLFEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: PPARA_MOUSE
Sequence: MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
What is the function of this protein?
Ligand-activated transcription factor.  Key regulator of lipid metabolism.  Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC).  Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety.  Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids.  Regulates the peroxisomal beta-oxidation pathway of fatty acids.  Functions as transcription activator for the ACOX1 and P450 genes.  Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.  May be required for the propagation of clock information to metabolic pathways regulated by PER2.
What are the official names of this protein?
Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: BAMA_SHIDS
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTINDEDISNTIRALFATGNFEDVRVLRDGDTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTIADIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAEIQQINIVGNHAFTTDELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYVTVNITEGDQYKLSGVEVSGNLAGHSAEIEQLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSMPEINDADKTVKLRVNVDVGNRFYVRKIRFEGNDTSKDAVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYAVGINGTKNDYQTYAELSVTNPYFTVDGVSLGGRLFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYNSLRAGLGYVHNSLSNMQPQVAMWRYLYSMGEHPSTSDQDNSFKTDDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVTLDTATYVPIDDDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYFPHQASNYDPDYDYECATQDGAKDLCKSDDAVGGNAMAVASLEFITPTPFISDKYANSVRTSFFWDMGTVWDTNWDSSQYSGYPDYSDPSNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: MATK_APHFC
Sequence: MEEIKKYLKLEISQQRNFIYPLIFQEYIYAFAYDRGFSRSILILSENLGYDNKSSLLLVKHLITRIYQHNYFIIAPDDSNPNPFWVCSKNFFYEIILEGFAFIVEIPFSLKLISCLEEKNKKIVKYQNLRSVHSIFPFLEDNFSHLNCLFDILIPHFVHTEILVQTFRYCITDVSFLHLLRFFLYKYCKWNSLMTPKKASYSFSKSNQRLLLLLFNIHVYEYESFFVFLHNHSSHLRSIHFEVLLERIHFYGKMECLINIFIKLKDFHANLWLVNESCIHYIRYQRKLIMASKGTSFFMNKWKFYFITFWQCYFSLWFYTRRIYINQSSNHSFEFFGYLSSLRMNPSVVRSQIIENSFLINNIIKKVDTLVSIIPLISSLAKAKFCNVLGHPTSKPIWADLSDYNIIDRFGCICRNLFHYHSGSSKKKFLYRIKYILRLSCARTLARKHKTTVRTFFKIFGSELLEEFLMPEEYVFFFTLSKASCSLQGVYISRIWYLDIISINNLTNYK
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
Protein: KXD1_YEASB
Sequence: MVTGISEENDDEETFSAVHSSTPSINSQSYAIPITEEMSSSFHDSISTTSNSSGSFDSDGSNVSBVVEQNEMDNESNVDEDLFLDNDIPQSSNLLPTDAQDPGPIFDVSRYIFDSLKQSIDSADFSEALSLQTKTSAVINSKSLELKQYIDEMKSRLTQLQEKFENGEATSKKIKRDLETSRKNIDYLNAALRVDFPIEFNQAREKILERRLNEDHDC
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit KXD1, BLOC-1 subunit KXD1, KxDL homolog.
What is the protein family that this protein belongs to?
Belongs to the KXD1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: PUR5_PSEU2
Sequence: MSKQPSLSYKDAGVDIDAGEALVERIKSVAKRTKRPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDTIGIDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDTAAQVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSKVAAGDALLALPSSGPHSNGYSLIRKIIEVAGADIENIQLDGKPLTELLMAPTRIYVKPLLKLIKETGAVKAMAHITGGGLLDNIPRVLPQGAQAVVDVASWQRPAVFDWLQQQGNVAENEMHRVLNCGVGMVICVAQEHVEAALKVLRDAGEQPWVIGQIASAAEGAAQVELKNLKAH
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP140_MYCTO
Sequence: MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIVDVVGRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRGFDCWLEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP
What are the official names of this protein?
Putative cytochrome P450 140.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: ISPG_THEFY
Sequence: MSVDLGMPVAPPQPLAPRRKTRQVMVGNVPVGGDAPISVQSMTTTVTADINATLQQIAELTAAGCQIVRVAVPSADDAEALPIIAKKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIKKFDDKVGEIAKAASEAGIPIRIGVNAGSLDKRLLAKYGKATAEALVESALWECSLFEEHGFHDIKISVKHHDPVVMIRAYRMLAERCDYPLHLGVTEAGPAFQGTIKSAVAFGALLAEGIGDTIRVSLSAPPAEEVKVGIQILESLGLRQRGLEIVSCPSCGRAQVDVYTLANRVTAGLEGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGKVIKTVPESQIVETLIEEALRIAEEMRAEGVPSGQPSVDVAG
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.