PharMolix/UniProtQA huggingface dataset:
Protein: HACA_ASPFU
Sequence: MEDNFASVVESLSGTSASALPLLTVSPADTSLKAPETKVQETKTEEKKPPKKRKSWGQELPIPKTNLPPRKRAKTEDEKEQRRIERVLRNRAAAQTSRERKRLEMEKLENEKIQMEQQNQFLLQRLSQMEAENNRLSQQLAQLTAEVRNSRNSTPKPGSPATASPTLTPTLFKQEGDELPLERIPFPTPSITDYSPTLKPSSLAESSDVTQHPAVSVGGLEGPGSALPLFDLGSGVEHDAANDIAAPLSDDDFHRLFNGDSSTEPDSSVIEDGFSFDILDSGDLSAFPFDSMVNFDSEPVALEGIEPAHGLPNETPYQTSGLQPSLGASTSRCDGQGIAAGC
What is the function of this protein?
Master transcriptional regulator of the unfolded protein response (UPR) that recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes (PubMed:19132084, PubMed:22028661, PubMed:21217201).  In the canonical UPR pathway, the ireA RNase splices the cytoplasmic mRNA hacA, which alters the reading frame to allow translation of the bZIP transcription factor hacA (PubMed:19132084, PubMed:33087521).  Induces the expression of pmrA, scrA and spfA in response to UPR (PubMed:32487759, PubMed:34663092).
What are the official names of this protein?
Transcriptional regulator of the unfolded protein response hacA, BZIP transcription factor hacA.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
Protein: Y712_ARCFU
Sequence: MRRLAILLSLAGIADSSYLLLSEAVPCPTGVCASISVFSLPPFVPALLGLCWFVLSIVVFTAGVNRALLTFWRFSGVFGESFLGTYAVLHGYFCPYCFTAYGIGIVVVAISEKLYG
What are the official names of this protein?
Uncharacterized protein AF_0712.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OTX2_XENTR
Sequence: MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPSKKKPSPAREVSSESGTSGQFSPPCSTSVPVISSSTAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLSGAGATLSPMGTNAVTSHLNQSPAALSSQAYGASSLGFNSTADCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL
What is the function of this protein?
May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures.  Activates the head organizer gene cer1 by acting synergistically with siamois and mix-A/mix. 1 through the 5'-TAATCT-3' element of the cer1 promoter.  Also binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to stimulate expression (By similarity).
What are the official names of this protein?
Homeobox protein OTX2, Orthodenticle 2.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ISPDF_AGRRK
Sequence: MTQMHSTQPMSIGIVIVAAGRGERAGSPEEGPKQYRAIGGRPVIAHTLEKFVTWPQTTKIVIVIHRDDEKLLRSAQETIVDSSGVEIAFGGTTRQQSVLAGVRQLEKTGVSHVMIHDAVRPFFDHDLLDRVAAALAAGAPAVLPAMPVTDTLKRADTDALVTETVPRAGLYAAQTPQSFRLADILAAHEKAAADNKTDFTDDAAIAEWAGLPVTLVAGSADNVKLTIKRDIAMADEKLSAGLLPDVRTGNGYDVHQLEPGDGVTLCGVFIPHDQTLKGHSDADVALHALTDALLATCGAGDIGDHFPPSDPQWRGAPSRIFIEHAARIVRDHGGTIMNADVSLIAEAPKVGPHREAMRAKLSEFLGISLERCSVKATTNEQIGFVGRREGIAAIATATVVYRGGRP
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: G6PI_LEPBA
Sequence: MSNLKISDRFVKPFLDQSKLEKELERAEMARQTVLNGSGLGNEFLGWVNLPSQTKAEDLQNIRKAAELIQSHSQYLVVVGIGGSYLGARAVIEALTPEFSTPETQKKTVKILYAGHHLDADYHFRLLAFLENKEFSVNVISKSGTTTEPAIAFRLLLSLLERKYGKENIKHRVFATTDRSKGALKHLADEYKFPTFVIPDDVGGRYSVFTPVGLLPIAAAGFSINKLMDGAKQMESELKSTASKDGNLACFYAAIRNGLYSLGKTTEIFVSYNPSFGYVSEWWKQLFGESEGKNGKGIFPASVQFTTDLHSMGQYIQDGERKLMETVIKVEAPKQDVYLTEKTDDNDGLNYLAGKKLSEVNQSAMLGTLIAHKDGGVPCLEITLPSINEETLGELLYFYEFSCAVSGYMLGVNPFDQPGVEDYKNNMFALLGKKGYEKRKEEILSHLGFS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HNS_HAEIN
Sequence: MNELVRGLTNLRSLRAAVRELTLEQAENALEKLQTAIEEKRANEAELIKAETERKERLAKYKELMEKEGITPEELHEIFGTKTVSIRAKRAPRPAKYAFIDENGEHKTWTGQGRTPRPIQNALNKGKSLSDFEI
What is the function of this protein?
A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction.  Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome.  As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes.  A subset of genes are repressed by H-NS in association with other proteins (By similarity).
What are the official names of this protein?
DNA-binding protein H-NS homolog.
What is the protein family that this protein belongs to?
Belongs to the histone-like protein H-NS family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MIAA_MYCBP
Sequence: MRPLAIIGPTGAGKSQLALDVAARLGARVSVEIVNADAMQLYRGMDIGTAKLPVSERRGIPHHQLDVLDVTETATVARYQRAAAADIEAIAARGAVPVVVGGSMLYVQSLLDDWSFPATDPSVRARWERRLAEVGVDRLHAELARRDPAAAAAILPTDARRTVRALEVVELTGQPFAASAPRIGAPRWDTVIVGLDCQTTILDERLARRTDLMFDQGLVEEVRTLLRNGLREGVTASRALGYAQVIAALDAGAGADMMRAAREQTYLGTRRYVRRQRSWFRRDHRVHWLDAGVASSPDRARLVDDAVRLWRHVT
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: GLYCO_RYSV
Sequence: MNIIKRAGVFIGLVYFTVLLIIYGEHIVRSYATEDCMPAGLYYYAEGAAYTNLPVCKDEPKSSYKGTELFPTSPNIDKPLRMTTDIMVHPISSTSDLGPMDVPPDMYPMYSCPNLSNSSPLPLWYGSCINSCQITSSKETMAVTVWAINSTVDIIMGYKLTTFFETKFSHVGPFGGCSISLVGSEPRSAPEALISGWRSKILSQGNIQDAAWYLYNDPECNYFSDIYSSGFFVRIDRIKLTVLIDAVGNLYLSDLVAGSYDSYDKGFATHGNNVWIWDTDRVKVDNNCYFKQTDDTYCDYDNTTGYILCKTIGVSFRSELQTRVESPCAGHLNISTDGVIYRLEGTADTPSTQDRLSSILKNNVNLGMESLISLINDVFTNIESSYCTGMCDLMEVILSNYPTATTVLETPIGPWLPITTNGHTVMTACSSDPNWVIKTPVSYCYSKKMIKVVNKDTMREAWWRIVNSYIILNETCTDENTTSFNLVKERMELRQDITYSFWRGDLIVSYPYNKSRWITYKDEKIQRSSKWFDKLLPLRYNHPITLDNITMELINHTRDIYDVHVYPSQGSTSKRPMSDVIGRVGAAGSNLIKHLVKGIGETFFWVTQHIELICDILIIIVCVVIGYCVVLKPILYITMRGREKQQPVIVMRDEGRSHLFSRSTATNAL
What is the function of this protein?
Attaches the virus to host cellular receptor, inducing endocytosis of the virion.  In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane (By similarity).
What are the official names of this protein?
Glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the nucleorhabdovirus glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: ENGB_STRPD
Sequence: MAEEQVLNTHNASILLSAANKSHYPQDDLPEIALAGRSNVGKSSFINTILGRKNLARTSSKPGKTQLLNFFNIDDKLRFVDVPGYGYAKVSKSERAKWGKMIEEYLTTRDNLRAVVSLVDLRHAPSKEDIQMYDFLKYYDIPVIVVATKADKIPRGKWNKHESVVKKALNFDKSDTFIVFSSVERIGIDDSWDAILEQV
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: CYB_ABRLO
Sequence: MTIMRKTHPLLKIINHSFIDLPTPSNISSWWNFGSLLGICLIIQILTGLFLAMHYTSDTATAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFIHVGRGIYYGSYMLSETWNIGIILLLTTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITAFVLVHLLFLHETGSNNPSGLNSNSDKIPFHPYYTIKDLLGVILLLMVLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYXLFAYAILRSIPNKLGGVLALILSILILAAFPLLNSSKQHGLIYRPISQTLYWIFVSNLLILTWIGGQPVEYPFTVIGQIASILYFAIIIILMPXANMIENNILKLXY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: OTU9_ARATH
Sequence: MGYEPDPDALRWGLHDLEVCTLTNAGSCSSVTRYESGGGGTQGYVREGYNQPVTGYVDNDAVIAQFYQDELSRVARAEASGINSLSPTSVVAQDWPHPHQGQENQGEAIDITQESDILHNHNGNMEDKNVARIRFEGGQSSPSRDDDSVCSVEIEEESWSEVGKRLNQMIPIAHVPKINGELPSEDEQISDHERLFQRLQLYGLVENKIEGDGNCQFRSLSDQLYRSPEHHNFVREQVVNQLAYNREIYEGYVPMAYNDYLKAMKRNGEWGDHVTLQAAADLFGVRMFVITSFKDTCYIEILPHFQKSNRLICLSFWAEVHYNSIYPEGELPIPEGKKKKKYWVF
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (Probable).  Cysteine protease with a preference for 'Lys-63' and 'Lys-48' -linked ubiquitin (UB) tetramers as substrates (PubMed:24659992).  Cleaves also RUB-GST fusion (PubMed:24659992).
What are the official names of this protein?
OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 9, OTU domain-containing protein 9, Deubiquitinating enzyme OTU9.
What is the protein family that this protein belongs to?
Belongs to the peptidase C85 family.
Protein: RK20_OENGL
Sequence: MTRIRRGYIARRRRTKTRFFASSWRGARGNLTRAIIQQRIRAWFSSHRDRTRQKRDFRRLWITRINAAIRENGRSSIYSKLIHNLYKRQLFLNRKMLAQLAILNRNCLYMISNQILKEVDWQESATILEI
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UL49_HHV6Z
Sequence: MFYLKKLLRQLLAPLCKHGPYTHLQLFVMGDACVPGKCVLTMFLTNKKFLNKEVTEKFYNEFFAIWLRCRPETRFITKRLFNKMVMTKGLFVLLAYLYFVYRQCKVLELLSLYKLKRIKWMDVETRFRVYPSYKLNKLLEMPSFSEINELHMFLFEQQLLLPIPTHVNLPCMRLFCLRDYEQTETVMLRYRQREHVLSFPSMLQKYALKSPAGNFMFTMAKALVENFCFSADRYLIPVEHNNLVPMVPSKPERGDFPKILTFALATSLKDGLATSVISLPVMCYCKTKCSRFILEESYICVICAKCGHCLNSGKEKLCSPQGFSLSSMFYFRDKQEKNLIYSMHTDVMYCSLCGSQQLVFERIYEMSEHCVLGMKVETVSWKAVIGTNSACTILNDNVKFDVIVPCSCRSCYSTVHLYNVTVKKLLRLVSHGSDFQCQHCQHSFRETCLDLEDCVNICQGCQISQNVRCI
What are the official names of this protein?
Protein U33.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: RR12_PHAVU
Sequence: MPTMKQLIRNTRQPIRNVTKSPALQGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQQGRSKYGAKKPK
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits (By similarity).
What are the official names of this protein?
30S ribosomal protein S12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SOFL4_ARATH
Sequence: MDKEECSSSESGWTTYLSSPIKVDEDEVVDEDYYYEGYNIYNYSSKVEHEEERNKDSDDSMASDASSGPNYQRFHQKNKALDLKNGKNEGNSKSKNDDDHHNHYHDGKKTSNSYRKKDKKKRENKSTYRMK
What is the function of this protein?
Involved in cytokinin-mediated development.
What are the official names of this protein?
Protein SOB FIVE-LIKE 4, AtSOFL4.
What is the protein family that this protein belongs to?
Belongs to the SOFL plant protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COA3_YEAS8
Sequence: MVLNPSKYQDTRTWKMTPAMIRARKPFFKGNMLGLTLLLGVTGSVYYYTYHFLHKDNDFADVPIPPIDPQELEALKKEYEAKKKA
What is the function of this protein?
Required for assembly of cytochrome c oxidase (complex IV).  With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1 (By similarity).
What are the official names of this protein?
Cytochrome c oxidase assembly factor 3, mitochondrial, Cytochrome c oxidase protein 25, Required for respiratory growth protein 10.
What is the protein family that this protein belongs to?
Belongs to the COA3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PYRDA_LACLA
Sequence: MLKTTFANAEFANPFMNASGVHCMTTEDLEELKASQAGAYITKSSTLEKREGNPLPRYVDLELGSINSMGLPNLGFDYYLDYVLKNQKEKAQEAPIFFSIAGMSAAENIAMLKKIQESNFSGITELNLSCPNVPGKPQLAYDFEATEKLLKEVFTFFTKPLGVKLPPYFDLVHFDIMAEILNQFPLTYVNSVNSIGNGLFIDSEAESVVIKPKDGFGGIGGAYIKPTALANVRAFYTRLKPEIKIIGTGGIETGQDAFEHLLCGATMLQIGTALHKEGPAIFDRIIKELEEIMDKKGYQSIADFHGKLKSL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase A (fumarate), DHOD A, DHODase A, DHOdehase A.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN330_HUMAN
Sequence: MPKKKTGARKKAENRREREKQLRASRSTIDLAKHPCNASMECDKCQRRQKNRAFCYFCNSVQKLPICAQCGKTKCMMKSSDCVIKHAGVYSTGLAMVGAICDFCEAWVCHGRKCLSTHACACPLTDAECVECERGVWDHGGRIFSCSFCHNFLCEDDQFEHQASCQVLEAETFKCVSCNRLGQHSCLRCKACFCDDHTRSKVFKQEKGKQPPCPKCGHETQETKDLSMSTRSLKFGRQTGGEEGDGASGYDAYWKNLSSDKYGDTSYHDEEEDEYEAEDDEEEEDEGRKDSDTESSDLFTNLNLGRTYASGYAHYEEQEN
What are the official names of this protein?
Zinc finger protein 330, Nucleolar autoantigen 36, Nucleolar cysteine-rich protein.
What is the protein family that this protein belongs to?
Belongs to the NOA36 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome, centromere. Note=Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis.
Protein: IF2_STRT2
Sequence: MSKKRLYEIAKEVGVESKVIVAKAQELGLSVKSHSSSVEEADANRITSSLKPGTAKDESKPAPKATPTPKEEKVEPKVDKASVAKSAPAKETSKAEVKEASVALKKPKSRNFKAEREARAKAEAERRKNGGGRDNRNRNQQGNDQGKRHNNDRRNQKGNGQGDHNKGNRDNSTNHDRNFQGKLRNDQNQNNRRDNARNNQAGPRIDLKARAAALKAEQNAEYSRQSETRFREEKAAEQRRAKEQEKARKEKQQVKVAVQKAAAETKPAPKPAPVAPQSAPTAQVQDTRRKKVRPNKSRDNRRVNEDGPKQTRNNKWNNQNQVRNQRNSNWNKNKNKKGKNNRGNSAPKPVTERKFHELPKEFEYTEGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGDTIELLMVDYGIEATKKEEVDNADIERFFVDEDYLNKDAMVERAPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIEEGGKKITFLDTPGHAAFTSMRARGASVTDITVLIVAADDGVMPQTIEAINHSKAAGVPIIVAINKIDKPDANPERVIGELAEHGVISTAWGGDSEFVEISAKFGQNIEELLETILLVAEVEELKADPTVRAIGTVIEARLDKGKGAVATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRIKTAGPSAPVSITGLNEAPMAGDHFAVYEDEKAARAAGEERAKRALMKQRQQTHRVSLDNLFDTLKAGEMKTVNVIIKADVQGSVEALAASLLKIDVEGVRVNVVHSAVGAINESDITLAEASDAVVIGFNVRPTPQARQQAETDEVEIRLHSIIYKVIEEIEDAMKGMLDPEFEEKIIGEAVIRETFKVSKVGTIGGFMVTNGKITRDSSARVIRDGVVIFDGKLASLKHYKDDVKEVGNAQEGGLTIENYNDIKVDDVIEAYIMEEIKR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARC2B_ARATH
Sequence: MAYLERASPTLKETLLKIYRAEKPIEVDQHFHEFGSIEYHIKYSVSDPNIVHVSTSTLLETQGAVTLKEISSYTYEVIKNIGVGVIDIVDPPRLGFQLTLGLNLDNIPRGKEAIKIITRISELQAIILSSQLKEMLRSLNFQDDSRSINNMPIRIVYHPSEPFYVFKQPEKITAVFPMNFKDNSDVVIATSFFQELVEVGSQKDMGKAPQCSWSPIPPLQLRGEPVQDLTTNSGFVSFDITSRHIEGKRLDKTVWNLLNFYACAKYHIKCSRGYIQRRMRKRMETLVKLLNNTSLEEEAAQNENGRCKYVKEFVKVPKGKLMMKQRCKEMTRRVKISKFRIKINGCARFRFNQRWISLPKFSSKPSDKSYTKLD
What is the function of this protein?
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the mother actin filament (By similarity).  Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development (By similarity).
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 2B, Actin-related protein C2B, Arp2/3 complex 34 kDa subunit, p34-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection.
Protein: LAIR1_MOUSE
Sequence: MSLHPVILLVLVLCLGWKINTQEGSLPDITIFPNSSLMISQGTFVTVVCSYSDKHDLYNMVRLEKDGSTFMEKSTEPYKTEDEFEIGPVNETITGHYSCIYSKGITWSERSKTLELKVIKENVIQTPAPGPTSDTSWLKTYSIYIFTVVSVIFLLCLSALLFCFLRHRQKKQGLPNNKRQQQRPEERLNLATNGLEMTPDIVADDRLPEDRWTETWTPVAGDLQEVTYIQLDHHSLTQRAVGAVTSQSTDMAESSTYAAIIRH
What is the function of this protein?
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells.  Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11.  It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.  May also play its inhibitory role independently of SH2-containing phosphatases.  Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta.  Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion.  Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.  Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).
What are the official names of this protein?
Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, mLAIR1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ALGB_PSESM
Sequence: MEAATENQGRILLVDDESAILRTFRYCLEDEGYSVATANSAAQADTLMQRQVFDLCFLDLRLGEDNGLDVLAQMRIQAPWMRVVIVTAHSAVDTAVDAIQAGAADYLVKPCSPDQLRLATAKQLEVRQLSARLEALEGEVRKPKDGLDSHSPSMMAILETARQVAVTDANILILGESGTGKGELARAIHGWSKRAKKSCVTINCPSLTAELMESELFGHSRGAFTGASESTLGRVNQADGGTLFLDEIGDFPLTLQPKLLRFIQDKEYERVGDPVTRRADVRILAATNLNLEDMVRSGRFREDLLYRLNVITLHLPALRERSEDILTLADRFLARFVKEYARPARGFSEEARAALLNYRWPGNIRELRNVIERASIICPQERVEVSHLGMAEQPANNAPRVGAALSLDELEKAHIGAVLATSETLDQAAKTLGIDASTLYRKRKQYNL
What is the function of this protein?
Positive regulator of the alginate biosynthetic gene algD.
What are the official names of this protein?
Alginate biosynthesis transcriptional regulatory protein AlgB.
Protein: DUF2_ARATH
Sequence: MEQMIFIRKDDKVEVFSEEEELKGSYYRAILEDNPTKSGHNKLKVRYLTQLNEHRLAPLTEFVDQRFIRPVPSEDVNDGVVFVEGLMVDAYLKDGWWTGVVVKTMEDEKFLVYFDCPPDIIQFEKKKLRVHLDWTGFKWIRPDNKELVKSVFSCGTMVELRFDCAWIPVIVIKELEKDKRFLVKYWNKSYSCRESKNLIVDSLRLRPMQPPLSVGKYELLDHVEAFSGFEWRQGVVRGIVFEGRYMVSFGATKEASQFNHSDIRPPMEWEDGVWHKRTKPKRQKETSLDGNRNVQTKEPPGNEMADDVKKESGLPITLGVTATKNKTQGKVSPVPMKNGFGNESTREKMPEEPKIKYYTRKRKRGGLKLNSYINKTVLSSDRTPNVVKNSASNAEENHAKHTIMVLPFAKKSPVWKTYESLEVFKSVSHSLHFSPLFETKQDFREGYAIGMMVTYFGLLEKFKDLEADVPVSQLNSLKDSFSELEKHGFNVTTPLSRIDKLLALKDRQLYIMEELKGFDKEMTNEFSKAKQEFDDMEQKILEVKHKIIELQRQEAALKEQKEAEKEQKDAAWKKICQMESCAKDLNVELEDVEFEFETILSAPW
What is the function of this protein?
May be involved in the polar growth of plant cells via transportation of RNAs.
What are the official names of this protein?
DUF724 domain-containing protein 2, AtDUF2.
Protein: DUS2L_HUMAN
Sequence: MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMIQCKRVVNEVLSTVDFVAPDDRVVFRTCEREQNRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKQYSTKGGMGAALLSDPDKIEKILSTLVKGTRRPVTCKIRILPSLEDTLSLVKRIERTGIAAIAVHGRKREERPQHPVSCEVIKAIADTLSIPVIANGGSHDHIQQYSDIEDFRQATAASSVMVARAAMWNPSIFLKEGLRPLEEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSREICEAFGLGAFYEETTQELDAQQARLSAKTSEQTGEPAEDTSGVIKMAVKFDRRAYPAQITPKMCLLEWCRREKLAQPVYETVQRPLDRLFSSIVTVAEQKYQSTLWDKSKKLAEQAAAIVCLRSQGLPEGRLGEESPSLHKRKREAPDQDPGGPRAQELAQPGDLCKKPFVALGSGEESPLEGW
What is the function of this protein?
Dihydrouridine synthase.  Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057).  Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616).
What are the official names of this protein?
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like, Dihydrouridine synthase 2, Up-regulated in lung cancer protein 8, URLC8, tRNA-dihydrouridine synthase 2-like, hDUS2.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Note=Mainly at the endoplasmic reticulum.
Protein: RK23_LOTJA
Sequence: MNGIKYAVFTDKSIRLLGKNQYTSNVESGSTRTEIKHWVELFFGVKVKAMNSHRLPAKGRKVRLIMGHTMHYRRMIITLQPGYSIPPLRKKRT
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUOK2_RHIEC
Sequence: MVPLWWYIVLGVVLFVIGAAGVLIRRNILVVLMSLELLLNSVNINFIAFGHYYDDFRGQIFAIFVIAITAAEVAVALGILVALVRNKSTLKVDDVTMMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K 2, NADH dehydrogenase I subunit K 2, NDH-1 subunit K 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BUD26_YEAST
Sequence: MILIFFAYISRRETVSQRQTSTIVYNITLMFSTLRCALKILAQIKKRLQQTSSNHENKKYEEVIKDHVGVKIQNIICLLAFVLVVYYQMRCKKMT
What are the official names of this protein?
Putative uncharacterized protein BUD26.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.