PharMolix/UniProtQA huggingface dataset:
Protein: SLY1_YEAST
Sequence: MAVEEIASRKDISLRDMQISAILKMLFLNKDLNNNDNITTITDDIFNQQEIIWKVLILDIKSTATISSVLRVNDLLKAGITVHSLIKQDRSPLPDVPAIYFVSPTKENIDIIVNDLKSDKYSEFYINFTSSLPRNLLEDLAQQVSITGKSDKIKQVYDQYLDFIVTEPELFSLEISNAYLTLNDPKTTEEEITGLCANIADGLFNTVLTINSIPIIRAAKGGPAEIIAEKLGTKLRDFVINTNSSSTSTLQGNDSLERGVLIILDRNIDFASMFSHSWIYQCMVFDIFKLSRNTVTIPLESKENGTDNTTAKPLATKKYDIEPNDFFWMENSHLPFPEAAENVEAALNTYKEEAAEITRKTGVTNISDLDPNSNNDTVQIQEVVKKLPELTAKKNTIDTHMNIFAALLSQLESKSLDTFFEVEQDPGSTKTRSRFLDILKDGKTNNLEDKLRSFIVLYLTSTTGLPKDFVQNVENYFKENDYDINALKYVYKLREFMQLSNMSLQNKSLEDGSDSAFKPSNLTLSGIYGLTEGKLQGGVGSLISGIKKLLPEKKTIPITNVVDAIMDPLNSSQKNLETTDSYLYIDPKITRGSHTRKPKRQSYNKSLVFVVGGGNYLEYQNLQEWAHSQLHNPKKVMYGSTAITTPAEFLNEISRLGASNSSNNDA
What is the function of this protein?
Able to suppress the functional loss of YPT1.  SLY1 is essential for cell viability.  May interact indirectly, or directly with YPT1.
What are the official names of this protein?
Protein SLY1, Suppressor of loss of YPT1 protein 1.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: IRAP_ECOL6
Sequence: MKNLIAELLFKLAQKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRDYVKKLLRHPRQ
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraP.
What is the protein family that this protein belongs to?
Belongs to the IraP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FSAB_ECOLI
Sequence: MELYLDTANVAEVERLARIFPIAGVTTNPSIIAASKESIWEVLPRLQKAIGDEGILFAQTMSRDAQGMVEEAKRLRDAIPGIVVKIPVTSEGLAAIKILKKEGITTLGTAVYSAAQGLLAALAGAKYVAPYVNRVDAQGGDGIRTVQELQTLLEMHAPESMVLAASFKTPRQALDCLLAGCESITLPLDVAQQMLNTPAVESAIEKFEHDWNAAFGTTHL
What is the function of this protein?
Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction.  Can utilize hydroxyacetone as an alternative donor substrate.  Is also able to catalyze the direct self-aldol addition of glycolaldehyde.  Is less catalytically efficient than the isozyme FsaA.  Does not display transaldolase activity.
What are the official names of this protein?
Fructose-6-phosphate aldolase 2, Fructose-6-phosphate aldolase B, FSAB.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYG1_RAT
Sequence: MGRGFLRGVLTLLPLRSVLQVQHCMLVSEPDLPPKRPRNNLMAPPRIGTHNGTFHCDEALACALLRLLPEYRNAEIVRTRDPEKLALCDIVVDVGGEYNPQRHRYDHHQRTFTETMSSLCPGKPWQTKLSSAGLVYLHFGHKLLAQLLGTSEEDSVVDTIYDKMYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVSRLNPTWNQPDQDTEAGFRRAMDLVQEEFLQRLNFYQHSWLPARALVEEALAQRFKVDSSGEIVELAKGGCPWKEHLYHLESELSPTVAITFVIYTDQAGQWRVQCVPKEPHSFQSRLPLPEPWRGLRDEALDQVSGIPGCIFVHASGFIGGHHTREGALNMARATLAQRTAPVPLANAVVQ
What is the function of this protein?
3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion.  Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk.  In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation.  In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins.
What are the official names of this protein?
MYG1 exonuclease.
What is the protein family that this protein belongs to?
Belongs to the MYG1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Mitochondrion matrix. Nucleus, nucleolus.
Protein: PYRD_RHIL3
Sequence: MIDPFKRLARKGLFLFDPETAHGMSIAALKSGLVPACQLTPDPRLRQTVAGLTFENPLGMAAGYDKNAEVPEALLKLGFGFTEIGTVTPKPQSGNPRPRIFRLVEDEGVINRLGFNNEGHDAAFGRLAALRGGGMIGVNIGANKDSEDRIADYVAGIRRFYSVARYFTANISSPNTPGLRDLQGRESLAVLLSAVLAARDEMGAASGRKIPVFLKIAPDLTEEGMDDIAAEALSHALDGLIVSNTTLSRDGLKDQRQAKETGGLSGVPLFEKSTAVLARMRKRVGPDLPIIGVGGVSSAETALEKIRAGADLVQLYSCMVYEGPGLAGDVVRGLSKLLDREKAASIRELRDTRVDYWAARKV
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL33_CAMJR
Sequence: MRIKVGLKCEECGDINYSTYKNSKNTTEKLELKKYCPRLKKHTLHKEVKLKS
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PDE5_CAEEL
Sequence: MDDASVLKYLQENPKLVEDFVVSNEISPETFKRWAVRRTMKYKNVKNGTSGGTGAWTEPDLSMKRRVILETSDNRTRILYEITQCCGQLIGTNSIELIVQNDEGAFSCRKTENGELKLKKVKTSKSADYIQTIVNAGNQTIAEIHFYTQLDSTEKSIVNAVCTWAAATNYYSELYTHKQEGSDGQDIHENIAKQRKLSNFLLDVARSIFHDIVSMDAVIIKVMNFAQKLVDADRASLFLVDSKNAQIYARIFDVGTGDEEHVRVNSEGQKEIRFDMSKGIAGYVASTGEGLNIENAYEDERFNADVDSKTGYTTKTILCMPILIRGIVIGVVQMVNKHDGVFTRQDEDAFEIFAVYCGLALHHAKLYDKIRRSEQKYRVALEVLAYHSVCNADEVNKLKKIEINNRIVELETIDFNGMRLSELEKPLYAVYMFKTLFADTLRFDTEDLIRFVLTVRKNYRRVAYHNWAHGWSVAHAMFATLMNSPDAFTKLEALALYVSCLCHDLDHRGKNNAYMKTMSTPLASIYSTSVMERHHFNQTVTILQQDGHNILKSLSSEDYKKTLSLIKHCILATDLALFFSNKAKLNVILDNNTFDINRQEHRLLTQAVMMTGCDLVASAKPWNIQTETVKVIFEEFYDQGDAERLSGKEPIPMMDRQQAHMLPQMQVGFMRGICMPCYDLIARIFPKNDKMRERCEYNAKKWEELAEEQRKKQEALAQQNGEANETQE
What is the function of this protein?
Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.
What are the official names of this protein?
Probable 3',5'-cyclic phosphodiesterase pde-5.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family.
Protein: GPDA_SYNWW
Sequence: MPKICILGSGSWGTAQALLLSSKEFQVILWGRIEDGVDSLQQDRENRRFLPGIRLSDTIVATSDLARALKGADIVVMAVPSQSLREVLEKARPYLGKDSCLVNTAKGLEISSGMRMSQVVEDVLGKQSRERYAVLSGPSHAEEVARNIPTAITVASYHKENAFLVQDLYMTPFFRVYTNPDVAGVELGGALKNIIALGTGIASGLGYGDNTQAALLTRGLHEIIRMGEAMGGEARTFSGLSGIGDLVVTCSSRHSRNRQAGILIGQGYSLEETLKQIAMVVEGAHTIRVVHRLACQLRIDMPICTACYNVLYANRKARDEVDDLMRRQKKHEIEEIVKRKKGW
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_RICPR
Sequence: MKTKILSLANEEVGEITLNKDIFAVEFIRDDIIKQVIDWQRAKAMFGNHKTKTVSEVSGTTKKPFKQKGTGNARQGSLRSVQMRGGGISHGPKVRSHAIKLPKKVRKLGLIHALSEKYAEEKLLIIDSLKLDKPKTSILVNLLSKFQGQSFFVIDGNKVDINFSLATKNIYNTLIVPQIGANVYDIIRHEYVLLSQEAVSFLEERLR
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PDXK_ECO27
Sequence: MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMQVVVVSADSVNVISHSRVKTDLKGTGDLFCAQLISGLLKGKALNDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA
What is the function of this protein?
B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i. e.  PNP, PLP and PMP.
What are the official names of this protein?
Pyridoxine/pyridoxal/pyridoxamine kinase, PN/PL/PM kinase, B6-vitamer kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxK subfamily.
Protein: ATPH_CHAGL
Sequence: MNPLIASASVIAAGLAVGLASIGPGIGQGTAAGQAVEGIARQPEVDGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MYB30_ANTMA
Sequence: MGRSPCCEKAHTNKGAWTKEEDQRLINYIRAHGEGCWRSLPKAAGLLRCGKSCRLRWINYLRPDLKRGNFTEEEDEIIIKLHSLLGNKWSLIAGALPGRTDNEIKNYWNTHIKRKLVSRGIDPQTHRSLNSATTTATATPTVNNSCLDFRTSPSNSKNICMPTTDNNNNSSSSTDDTKCNSSTTEESQSLITPPPKEEEKSVPLVDLELSLGLPSQSQCNKSVSLNSSSSGFYDLFRPPAKVAQRMCVCKWTLGLQKGEQFCNCQSFNGFYRYC
What is the function of this protein?
Transcription factor.
What are the official names of this protein?
Myb-related protein 330.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSHA_BACAH
Sequence: MTTFRELGLSDSLLQSVESMGFEEATPIQAETIPHALQGKDIIGQAQTGTGKTAAFGLPLLDKVDTHKESVQGIVIAPTRELAIQVGEELYKIGKHKRVRILPIYGGQDINRQIRALKKHPHIIVGTPGRILDHINRKTLRLQNVETVVLDEADEMLNMGFIEDIEAILTDVPETHQTLLFSATMPDPIRRIAERFMTEPQHIKVKAKEVTMPNIQQFYLEVQEKKKFDVLTRLLDIQSPELAIVFGRTKRRVDELSEALNLRGYAAEGIHGDLTQAKRMSVLRKFKEGSIEVLVATDVAARGLDISGVTHVYNFDIPQDPESYVHRIGRTGRAGKKGIAMLFVTPRESGQLKNIERTTKRKMDRMDAPTLDEALEGQQRLIAEKLQSTIENENLAYYKRIAEEMLEENDSVTVVAAALKMMTKEPDTTPIALTSEPPVVSRGGGSKKRGGNGGGYRDGNRNRSRDGRGGDGRNRDRNRDGRNRDGNRDRNREGSRDGNRGRRGEGQGRPGSSNGRGERKHHSRKPQA
What is the function of this protein?
DEAD-box RNA helicase possibly involved in RNA degradation.  Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase CshA.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. CshA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1051_HAEIN
Sequence: MFNKIFSWFENRLNPYPESNPTTPKKGLFRFIWSSITGMKGWIFLLAILTVGTGVMEAVLFQFMGTLVDWLGTFTPERLWQEKSHLLIGMAALLLISIVWGFLASAVHLQTLQGVFPMRLRWNFHRLMLGQSLSFYQDEFAGRVSAKVMQTALAVRDTVLTLANMFVYVLVYFITSGVVLVALDSWFLLPFITWIILFGLILRTLIPKLSKTAQRQADARSLMTGRITDAYSNIATVKLFSHGSREATYAKRSMQDFMVTVHAQMRLATSLDTLTYATNILLTLSTAILGIILWKNGQVGVGAIATATAMALRVNGLSRWIMWESARLFENIGTVNDGMNTLTKPHTIVDKPQASPLQVKQGEIKFNDITFAYDPTKPLLNHFNLTIKPGEKVGLIGRSGAGKSTIVNLLLRFYEAQQGEITIDGQNVLNVQQESLRRQIGLVTQDTSLLHRSVRDNIIYGRPNATDEEMVLAAERAEAADFIPFLSDSQGRKGYDAHVGERGVKLSGGQRQRIAIARVMLKDAPILLLDEATSALDSEVEVAIQESLDKMMENKTVIAIAHRLSTIAAMDRLIVLDKGQIVEQGTHAELLELNGLYAKLWNHQSGGFLSESAE
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein HI_1051.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SECA_POLNA
Sequence: MASNILTKIFGSRNDRLLKTYRKTVDQINALETQYEKLDDDQLRAKTQEFKDRVAAGETLDALLPEAFAVVREGSKRIMKMRHFDVQMLGGMSLHNGKISEMRTGEGKTLTATLPVYLNALTGKGVHVVTVNDYLASRDARWMGKLYNFLGMSVGINLPNMSREEKQAAYNADITYGTNNEFGFDYLRDNMVYEVGDRVQRGLNFAIVDEVDSILIDEARTPLIISGQAEDHTEMYLAINKVVPLLTRQEGEADPRTGEGVTTPGDYTIDEKTHQVFLTEQGHESAERILFEMGLIPEGATLYDPANISLMHHLYAALRGNLLYHRDQHYVVQEGEVVIVDEFTGRLMSGRRWSDGLHQAVEAKEGVQIQAENQTLASITFQNYFRLYKKLSGMTGTADTEAYEFQEIYGLETTVIPPNRVSKRDDQLDRVYKTTREKYEAAIKDIRECYERGQPVLVGTTSIENSEIIDQLLIKENLPHQVLNAKQHAREADIVAQAGRLKMITIATNMAGRGTDIVLGGNVEKLIEAVEADESLDTVAKEAEIARLQTQCKQENEQVKTLGGLRIIATERHESRRIDNQLRGRSGRQGDPGSSRFYLSLDDPLMRIFAGDRVRSIMERLKMPDGEAIEAGIVTRSIESAQRKVEARNFDIRKQLLEYDDVSNDQRKVIYQQRNDIMDASDLQPQIASLREGCFADLTRQYVPVESVEEQWDVAGLEKTLRDEWHIDLALRQEIESATAITDEEVLEKVSAAAEAAFADKLEKIGKENFTQFERVVLLQSIDSHWREHLSALDYLRQGIHLRGYAQKQPKQEYKREAFELFGQLLDSVKNEVTKTLMTVQVQSGEQLDQAAEALESRAENITNVTYTAPTETGEVETTVDEASQRRQQAVAGSAMPRVGRNDPCPCGSGKKYKLCHGKLT
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RL5_DESVV
Sequence: MTRLENIYREKVVPVLQKEFNYDSSMQVPGIVKVSLNIGLGAASQNNKLMEEALKELTVIAGQKAVVTRAKKSIASFKLREGMPIGCRVTLRKERMWDFLDKLINFALPRVRDFRGVPDRGFDGRGNFTLGIKEHAIFPEMEADRVENPKGMNITIVTTATTDKEGKLLLDQLGMPFRK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: D19L3_HUMAN
Sequence: MMSIRQRREIRATEVSEDFPAQEENVKLENKLPSGCTSRRLWKILSLTIGGTIALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLVQGFHGLIYDNKTESMKTINLLQRMNIYQEVFLSILYRVLPIQKYLEPVYFYIYTLFGLQAIYVTALYITSWLLSGTWLSGLLAAFWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFISTFLFSLTWQFNQFMMLMQALVLFTLDSLDMLPAVKATWLYGIQITSLLLVCILQFFNSMILGSLLISFNLSVFIARKLQKNLKTGSFLNRLGKLLLHLFMVLCLTLFLNNIIKKILNLKSDEHIFKFLKAKFGLGATRDFDANLYLCEEAFGLLPFNTFGRLSDTLLFYAYIFVLSITVIVAFVVAFHNLSDSTNQQSVGKMEKGTVDLKPETAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSPEIWELLLKSVHLYNPKRICIMRYSVPILILLYLCYKFWPGMMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDSSLRERTRAVYQIYAKRAPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHMMDGPGENDPDLKPADHPRFCEEIKRNLPPYVAYFTRVFQNKTFHVYKLSRNK
What is the function of this protein?
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
What are the official names of this protein?
Probable C-mannosyltransferase DPY19L3, Dpy-19-like protein 3, Protein dpy-19 homolog 3.
What is the protein family that this protein belongs to?
Belongs to the dpy-19 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DMRT1_MOUSE
Sequence: MPNDDTFGKPSTPTEVPHAPGAPPQGKAGGYSKAAGAMAGAAGGSGAGGSGGASGSGPSGLGSGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENNASNPCLMAENSSSAQPPPASTPTPAASEGRMVIQDIPAVTSRGHMENTSDLVSDPAYYSSFYQPSLFPYYNNLYNYPQYSMALSAESSSGEVGNSLGGSPVKNSLRSLPAPYVPAQTGNQWQMKTSESRHPVSSQYRMHSYYGPPSYLGQSMSQIFTFEEGPSYSEAKASVFSPPSSQDSGLVSLSSSSPMSNESSKGVLECESASSEPSSYAVNQVLEEDEDE
What is the function of this protein?
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation.  Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm.  Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1.  Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes.  May act as a tumor suppressor.  May also play a minor role in oogenesis.
What are the official names of this protein?
Doublesex- and mab-3-related transcription factor 1.
What is the protein family that this protein belongs to?
Belongs to the DMRT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: O2T10_HUMAN
Sequence: MRLANQTLGGDFFLLGIFSQISHPGRLCLLIFSIFLMAVSWNITLILLIHIDSSLHTPMYFFINQLSLIDLTYISVTVPKMLVNQLAKDKTISVLGCGTQMYFYLQLGGAECCLLAAMAYDRYVAICHPLRYSVLMSHRVCLLLASGCWFVGSVDGFMLTPIAMSFPFCRSHEIQHFFCEVPAVLKLSCSDTSLYKIFMYLCCVIMLLIPVTVISVSYYYIILTIHKMNSVEGRKKAFTTCSSHITVVSLFYGAAIYNYMLPSSYQTPEKDMMSSFFYTILTPVLNPIIYSFRNKDVTRALKKMLSVQKPPY
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2T10, Olfactory receptor OR1-64.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TAP45_TETTS
Sequence: MEDNFELVFLKELPSLPDFSKVCFTGLILSFSNFPSSEQNQQKDVPHKIAIIQDSTGEAELFLDMYKFCQEEISVFKAITGIGVLKKKNIGAGQVCKIIVERFRIIHSADEEMLQYLLIQKYKLSKTLNEQQQIKQKEQQINQQKIDKVVQDKESKEHLLWKQQQIPQIKSNQENINTLKYKELIAGELMRITHKLLIQKLQQQQPANNNKQINEMDVESNELAEKKEVIIKIQEIAKDQQLYDTLSIQYQVDQKEQYYAKIAQSLEDFVSISALKMVSYIYPNISYQVSIGFFQNILDIATKTVKDRGALGCNYKYLKDKLTKALNLQQISYPLISESYISYLVHLFQDFNIIEIENEHKFYYKQAFQYDDS
What is the function of this protein?
Component of a CST-like subcomplex of the holoenzyme telomerase ribonucleoprotein complex, which stimulates telomerase complementary-strand synthesis (PubMed:26551074).  Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:26551074).  The CST-like subcomplex (also named 7-4-1) binds telomeric single-stranded DNA and coordinates telomere G-strand and C-strand synthesis (PubMed:26551074).
What are the official names of this protein?
Telomerase-associated protein of 45 kDa, p45.
What are the subcellular locations of this protein?
Chromosome, telomere.
Protein: GLMU_TROWT
Sequence: MKSDLAIVILAAGRGTRMRSSTPKVLHNIAGLPMVAHVLRGAQLLKPCKTIVVFRDVRVEQYIRNTFPDVLTVAQSDALYGTGFGVFSAIPWIRSESYGNTYPNTRHESHAEYELDACDLDTCNPASDRLNDQESLKGGRHIHTKSGDVTNNKPFPSRVLILYADVPLVPFQLLEELVRKPLKQAVGAIVTTHLDNPKGYGRVMRDNLGSIAKIIEDSNILPEQSINEVNTGVGIFDTEYLQDALNKLLKCHIAHSPNQDCVTNQDCVTNQDCVTNQDCVTNQDCVPAAHTEAHVLSPKVIVTEQIHKKAESEHQHAGQWMCRQDTVGAQNTKEEMRLTDIVEYFYNNGLRVNSITTSDSELLLGVNNRVQLAKTEKILNDQIIKRWQLYGVTIKSPETTWIDSTVQLSEDVLILPGCILSGRTRIEEGAVIGPFATISDSFIGKNTIVKRAEIIDARIEEGAVIGPFAFIRPGTVIGKDSKVGTFVEIKQSNIGPESKVPHLSYIGDANIGSHVNIGAGNIFANYDGKLKHETCIDDGVKTGAGNVFVAPVKVGRGAYTGAGSVIRDDIEEGALSLTELKQKTIPKWAENRGDG
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_NITEC
Sequence: MKFLFDLFPIILFFATYKIYGIYSATAVAIVATFAQIGWVWLRHRKVDNMLWVSLAIIIVFGGATLILQDETFIKWKPTVLYWLFAVILFLAHSFFGKNLIRAMMKDQIKLPEPVWVRLNISWSVFFGAMGALNLYVAYNYSTDTWVNFKLFGFMGLMFVFIILQALLLGKYMEKNDNQKI
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UVRC_NOVAD
Sequence: MRRAPERLSACHAMARKPQTPPDRETERFHEERAATTLRGADRPDIELGAGVIRETVQTLKPKPGVYRMLDARGDVLYVGKARALKNRVANYTQVERLPNRLRRMVSQTRSMTIVTTNSEAEALLLEAQLIKRFRPPYNVLLRDDKSFPFILLRGDHAFPRISKHRGARKAKGNYYGPFASAGSVNTTINALQKLFLLRSCNDGFMARRDRPCLLYQIRRCSAPCVGRISEADYGELVRQAKDFLGGKSGAVQREIEAQMHKAAEDLDFERAAMLRDRLRAATFIQGSQAINAEGVGNADVFAMATKGGQVAVQAFFIRGGQNWGHRAFFPSHTEGLSEEEVMTSFLAQFYEEVPPARLILVDRALPEADLLAEALCEAAGGKVEISVPQRGDRRRLMEQAQRNAVEALDRRMAESGTKAKVMRELAEFLELPEVPQRIEIYDNSHIQGTNALGAMVVAGPEGFVKGQYRKWNIKLAQTNDDFAMMREVMTRRFGRAQEEDPDRESGNWPDLVLIDGGKGQMSAVKEALGELGIEDVPLVAIAKGPHHGREGREVFHFPDGREKMLPVNSPVLFQLQVMRDEVHRFAIGAHRAKRSRAITASPLDEIPGIGPARKRALLLHFGTAGKVRAASLEDLQRAPGVSAAVAQTIYDFYHPSG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YGAH_ECOLI
Sequence: MSYEVLLLGLLVGVANYCFRYLPLRLRVGNARPTKRGAVGILLDTIGIASICALLVVSTAPEVMHDTRRFVPTLVGFAVLGASFYKTRSIIIPTLLSALAYGLAWKVMAII
What are the official names of this protein?
Uncharacterized protein YgaH.
Protein: RECX_HALH5
Sequence: MAIITRIEVQKRNNERYNIFIHQNGQDVYAFSVDEQVLIKQGLRKGLDIDAEQMKQILYEDEVQKTFNLALHYLSYRMRSVHEVRTYLKKKDREEPIIEHVLHRLTEQRLLDDHAFAEAFIQTKRATTSKGPLKLKQELAEKGVSEKTIEGALTTFSYEEQVEQVKAWLEKQKGRTFKGSSLAWKQKLSRQLLAKGYTSPVIEEAFADVPIKQEEEEEWEALKAFGEKAMRKYAGKKTGWELQQKVKQALYRKGFSLEMIERYLND
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
Protein: RHPN2_MOUSE
Sequence: MTDTLLPAAPQPLEKEGDDYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNQKVREQVRLELSFVNSDLQMLKEELEGLNISVGVYQGTEEAFTIPLIPLGLKETKEVDFSIVFKDFILEHYSEDSYLYEDDIADLMDLRQACRTPSRDEAGVELLMSYFIQLGFVESRFFPPTRHMGLLFTWYDSFTGVPVSQQTLLLEKASVLFNIGALYTQIGTRCNRQTQAGLESAVDAFQRAAGVLNYLKETFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKVCLPGIQNEFFVLVKVAQEAAKVAEAYRQLHAAMSQEPVKENIPYSWASVAYVKAYHYGALAHYFAATLLIDHQLKPGADEDHQEKCLSQLYDRMPEGMTPLATLKNAGQRVLLGKGHLHRAIGFHEESLREANLCKKLRDIQVLRDVLSAAHQRTQLKHTQHREDDDLLNLIDAPDVLPKTEREVKITFPDFSKVTVTDFFQKLGPLSVFSASKRWSPPRGIHFTVEEGDLGFTLRGNTPVQVHFLDPHCSASLAGAKEGDYIVSIQGVDCKWLTVSEVMKLLKSFGGEEVEMKVVSLLDSTSSMHNKCATYSVGMQKTYSMICLSMDDDDKADKTKKISKKLSFLSWGTSKNRQKSASTLCLPEVGLARSQNKKKLPTPFSLLNSDSSLY
What is the function of this protein?
Binds specifically to GTP-Rho.  May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity).
What are the official names of this protein?
Rhophilin-2, GTP-Rho-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the RHPN family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.