PharMolix/UniProtQA huggingface dataset:
Protein: KATG_ROSDO
Sequence: MDGNNVDPTGGCPVMHGGNTAMDKPVTKWWPNALNLDILHQHGARTNPMDPDYDHRAAVKALDFEAVKADVKALMTQDQDWWPADWGHYGGLMIRLAWHSAGTYRMQDGRGGAGSGNIRFAPLNSWPDNASLDKARRLLWPVKKKYGNALSWADLIILSGNMAYESMGLKTFGFGFGREDIWGPETDVYWGSENEWLAPSENRYGDLDDASTLENPLAAVHMGLIYVNPEGVNGQPDPARTAQHVRETFARMAMDDEETAALTCGGHTVGKAHGRGAVDNIGVEPEAAGIEAQGFGWSNPRHDGKATNAFTSGIEGAWTTHPTQWDMGYFKLLFGYEWQLTKSPAGAWQWEPIDIKEEDMPVDPTDPSKRHQPMMTDADMAMKVDPIYNEICQKFMADPEYFADVFGRAWFKLTHRDMGPKACYIGPDVPAEDLIWQDPIPAGSTEYDVAAVKARIADSGLSAADMIATAWDSARTFRGSDKRGGANGARIRLAPQKDWAGNEPERLAKVLGILEPIAAETGASVADVIVLAGNVGLEQSIKAAGYDVDVPFAQGRGDATADQTDAASFDVLEPLADGFRNWQKADYAVSAEEMMLDKAQLLGLTAAEMTVLVGGMRVLGVNHGNSKHGVFTDRAGQLTPDFFVNLTDMAYSWHPVDGENTYEIRDRATGAVKWTATSADLVFGSNSVLRAYAEVYAQDDNAEKFVRDFVAAWTKVMNADRFDLAA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: METK_CHLL2
Sequence: MSQSRYFFTSESVSEGHPDKVSDQISDAVLDEFLRQDPNSRVACETFVTTGQVIVGGEVTTKGIVDIQKIARRVVTEIGYTKGEYMFEANSCGVLSALHSQSPDINRGVDRKEEIADEFDRVGAGDQGMMFGYACTETPELMPAAIQFAQQLVKKLAEIRKEGKIMTYLRPDAKSQVTLEYIDDKVARVDAVVVSTQHDPEPAGMSEADFQAVIRKDIIENVVKVVIPAELLDENTKFHINPTGRFEIGGPHGDTGLTGRKIIVDTYGGAAPHGGGAFSGKDPSKVDRSAAYASRHVAKNIVAADLADKCTVQVSYAIGVARPVSIYIDTHGTAKHGLDDAEIQAKAEKIFDLRPAAIIRRFNLDRPHGWCYQDTAAYGHFGRDIFPWEKTDKVEELKKAFNLA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_ACIF2
Sequence: MFATFGFIALFAVLGAWARYGQTLLVQAAFGRGFPWATLSINVLGCFLMGFLFFETLERISVSPELRTGMLTGGLGAYTTFSTFSLETLVLFENGEAVKGLLYMFTSLFLCVGAAFAGAWISHST
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MYL9_PIG
Sequence: MSSKRAKAKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLEGMMSEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEASGFIHEDHLRELLTTMGDRFTDEEVDEMYREAPIDKKGNFNYVEFTRILKHGAKDKDD
What is the function of this protein?
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation.  Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).  In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).
What are the official names of this protein?
Myosin regulatory light polypeptide 9, 20 kDa myosin light chain, LC20, Myosin regulatory light chain 2, smooth muscle isoform, Myosin regulatory light chain 9.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts.
Protein: SYL_DESRM
Sequence: MQEHYDFKEIEKKWQEDWNKENTYQVPDFSERPKYYCLEMFPYPSGKLHMGHVRNYSIGDVVARFKTMQGYDVLHPMGWDAFGLPAENAAIKHGIAPATWTWDNIAHMRSQLKQLGLSYDWNREVATCHTEYYKWGQWLFLQLYKKGLCYKKHARVNWCPDCATVLANEQVVDGACERCSAVVEQKELDQWFFRITEYAQRLLNDLKLLKGWPDKVKIMQENWIGRSEGAELTFQVEGSDESITVFTTRPDTVYGVSYMVLAPEHPLVAKLIAGRPQEAEVIGFVNRVNKLTELDRTSSDKEGVFTGAYCINPFDGARVPILIANYVLYHYGTGAVMGVPAHDERDFEFAHKYNLPIKVVIYPAQDKEIRVEDMKEAYTADGIMVHSGPFDGSPNRQGIKKVIKYAEEKGIGKGIVNYRLRDWLISRQRYWGTPIPIVYCEKCGTVPVPEDQLPVILPTDVAFKPTGESPLKGRPDFVHTTCPQCGGPAQRETDTMDTFVDSSWYYLRYTSSRDTEYAWDKNKADRWMNVDQYIGGVEHAILHLLYSRFFTKVFYDLGLVNVQEPFENLLTQGMVLKDGSKMSKSKGNVVSPEEIIDRYGADTARMFILFAAPPERDLEWSDRGVEGSHRFLNRVWRLVYSLKDEVAGAPAISSVNAYVGVHKEMRRLTHYAIKKVTEDVSGRFNFNTAISTIMELVNGIYTYRDKVAAVERDTAVLAEAVNSTIILLAPFAPHIAEELWSATGHQGSVHKQPWLTFDSAALVEDEVEVAVQINGKVRERLNIPANMKPAEMQQYLMDMESVKILIGDKQIVKIIPVPGKLLNIVVK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLS_CLOPS
Sequence: MHLLINIIFLINIIFIISIIFIERRNPQTTWAWILILTFLPILGFIIYILFGQNITREKNFKRKILDDKTKQKYLNSFKSHYKLDNISLKYKDLIMMNFNNDNSTYTQRNDIDLYFDANSLFQEMIYEINKAEKFIHMEFYIFKSDEIGKKILQALTKKAKEGVEVKLLVDSIGNSIHKKDIDKLKAAGGDFKIFFPGFCKYINLRINYRNHRKILIIDSKVAFLGGFNIGDEYLGKDKNIGNWRDTHTKIKGLAINDLEARFLLDWSYANESDLDIDLKKYFINPHSTNLPNNIIGAQIVSSGPDHTEQQIKNGYFKIINSAKKNLFIQTPYFVPDEPMLEALRLAALSGVDVKIMLPGNPDHKFMEWIANSYFESLLNAGVKIYLYEKGFLHAKTIVADSSICSVGTANMDIRSFSLNFESNIFIYNEAISKSMEEQFFKDLKVCTKVTLESFEKRSIISRIGESIIRLVSPLM
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TDH_SHEB5
Sequence: MKALSKLKAEKGIWLVDAPKPVMGHNDLLIKIKKTAICGTDMHIYNWDEWSQKTIPVPMVVGHEYVGEVVDIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTSGVGVNREGSFAEYLVIPAFNAFKIPDDISDDLASIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVSKESLKDVMKELGMTEGFDVGLEMSGVPSAFHAMLDTMNHGGKVAMLGIPGGEMAIDWSKVIFKGLVIKGIYGREMFETWYKMASLIQSGLDISPIITHHFKIDDFQQGFDAMGSGQSGKVILSWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CI131_HUMAN
Sequence: MEWLLEDLLGAKGDMGLLWGQLTHALACRHCGSSCFQSPGNLVTLFLFVVWQIQRWWQLGRLRQLHPWCSGNMVQGKELPLLHRVAFLDHLCKQKSEVEEEGEEEEEGEDEASLDPLKPCSPTKEAPTGEQATPAPPQPSCGSEGLLKAIGIPEQTVMQPVSPSRSFPIFQILTSFPVRHKIASGNRQQQRKSQLFWGLPSLHSESLEAIFLSSGGPSPLKWSVCSSVFFNKLAFLPRSNLLLPQYHSSAQFSTHGAHTMEDLEGMAPDPQLLPPPSSPSVSSLLLHLRPFPVDHKGVLSGAEAPTQSPGTSPLEVLPGYETHLETTGHKKMPQAFEPPMPPPCQSPASLSEPRKVSPEGGLAISKDFWGTVGYREKPQASESSMPVPCPPLDSLPELQRESSLEDPSRYKPQWECRENSGNLWAFESPVLDLNPELSGTSPECVPPASETPWKGMQSRENIWVPADPVSPPSLPSVPLLESLVMGPQGVLSESKALWETMGQKENLWASDSPDPVHSTPPTTLMEPHRINPGECLATSEATWKDTEHSRNSSASRSPSLALSPPPALAPELLRVRSMGVLSDSEARCGDIQKTKNSWASKHPACNLPQDLHGASPLGVLSDSQSIVGEMEQKENCVPVFPGRGSSPSSNSVSKSHVSEPIADQSNYKPDGEAVEQRKNHWATELPAPSSLSTPLPEPHIDLELVWRNVQQREVPQGPSPLAVDPLHPVPQPPTLAEAVKIERTHPGLPKGVTCPGVKAEAPLSQRWTVPELLTHPGIHAWQWSRELKLRLKKLRQSPASRAPGPSQSFCSSPILSSTIPDFWGLPSCPPQQIYPPNPCPHSSSCHPQEVQRTVPQPVQSSHCHHFQSSSQLQPQESGRAEQGSQRGEKMKGKMVSQVPSQGPCVHMEAGVDYLSPGPGEPSNSKVLVSGKRKDKASASSSAKKREHPRKPKAGDHRRGTARLGLSTVTGKNHPAQARSLVEAPVSTFPQRSQHRGQSSQHTALPQLLLPKASGPQDQPEAGRRASDILTPRHCKHCPWAHMEKYLSFPTLKASLTRGLQKVLAKCLDNHRPLPTKSSQ
What are the official names of this protein?
Uncharacterized protein C9orf131.
Protein: DISC1_RAT
Sequence: MQGAGSRGAWIHSPSHCPGNGHGSPPAVAPQRRRLTRRPGYMRSTASPGIGFLSPAVGMPRPISAGLTGQEFYPSQSKARQCSLDLRSHCQDSLVGNPFLKGSLGPAVTSVGHLHPAQGSMRERMVHSGVHSGNDRRQSERLTGDSGCRQEFLSSDSSKSLASSLDVAWSKGSRGLKTVRPLVSPASNGPVDIPSLPGFQDTFTSNFSFIRLSLGAAGERGEAEGCLPSREAEPLHQSPQEMAAEGSGSDRPHGEPRHLWTFSLHAAPGLVDLAQGTRSNRQPECGMVSSSDAGFSSQDASPAGGRSDQDGGWADAHGWHALLREWEPMLQDYLLSNRRQLEVTSLILKLQKLQEKAVEDGDYDMAETLRQRLEDLEQEKGRLPWALPSQQPALRSFLGYLATQTHAALHGAPQRAGSDDPEAPLEGQRRTTAQDSLPGLAVTRRDWLMREKEQLQKEIEALRARVSVLEAKEQRLSQELEDQEMLLRWQGCDQMALVAQLSPGQLQEVSKALGETLTSARWAPFRVEPPETLRSLRERTKSLDLAVRELTEQVCSGEKLCSSLRKRLADLDTRLPALLEAKMLALSGSCFSTAKELAEEIWAVSSEREGLEMFLGRLLALSSRNTRRLGSVKEDYLRCRQDLALQEAAHKTRVKANTVKCTEVLEGQLSCCRCPLLERVWKADLEACQLLMQSLEIQEAGSSSHVEDEKQVHSTGEAAQTAALAVPRTPHPEEEKSPLQVLCEWNTYSASLPHCAAGLWKEESHVVFAEVGDKCEAIGMRLLHLEDQLLGAMHGHDEALFQSLQGELQMVKETLQTMFLQLQPAKEAGGEASASYSTAGAQEAED
What is the function of this protein?
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17035248).  Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus.  Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance.  Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation.  Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A.  Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development.  Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity).  Plays a role, together with PCNT, in the microtubule network formation (By similarity).
What are the official names of this protein?
Disrupted in schizophrenia 1 homolog.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria (PubMed:12506198). Colocalizes with PCNT at the centrosome (By similarity).
Protein: GRF7_ARATH
Sequence: MDFLKVSDKTTIPYRSDSLFSLNQQQYKESSFGFRDMEIHPHPTPYAGNGLLGCYYYYPFTNAQLKELERQAMIYKYMIASIPVPFDLLVSSPSSASPCNNKNIAGDLEPGRCRRTDGKKWRCAKEVVSNHKYCEKHLHRGRPRSRKHVEPPYSRPNNNGGSVKNRDLKKLPQKLSSSSIKDKTLEPMEVSSSISNYRDSRGSEKFTVLATTEQENKYLNFIDVWSDGVRSSEKQSTTSTPVSSSNGNLSLYSLDLSMGGNNLMGQDEMGLIQMGLGVIGSGSEDHHGYGPYGVTSSLEEMSSWLAPMSTTPGGPLAEILRPSTNLAISGDIESYSLMETPTPSSSPSRVMKKMTSSVSDESSQV
What is the function of this protein?
Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues.  Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation.
What are the official names of this protein?
Growth-regulating factor 7, AtGRF7, Transcription activator GRF7.
What is the protein family that this protein belongs to?
Belongs to the GRF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SUV91_HUMAN
Sequence: MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
What is the function of this protein?
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate.  Also weakly methylates histone H1 (in vitro).  H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones.  Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.  H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.  SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length.  Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes.  The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.  Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
What are the official names of this protein?
Histone-lysine N-methyltransferase SUV39H1, Histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, Lysine N-methyltransferase 1A, Position-effect variegation 3-9 homolog, Suppressor of variegation 3-9 homolog 1, Su(var)3-9 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Protein: NCAP_SINV
Sequence: MSTLKEVQDNITLHEQQLVTARQKLKDAERAVELDPDDVNKSTLQSRRAAVSALETKLGELKRELADLIAAQKLASKPVDPTGIEPDDHLKEKSSLRYGNVLDVNSIDLEEPSGQTADWKSIGLYILSFALPIILKALYMLSTRGRQTIKENKGTRIRFKDDSSYEEVNGIRKPRHLYVSMPTAQSTMKADEITPGRFRTIACGLFPAQVKARNIISPVMGVIGFSFFVKDWMERIDDFLAARCPFLPEQKDPRDAALATNRAYFITRQLQVDESKVSDIEDLIADARAESATIFADIATPHSVWVFACAPDRCPPTALYVAGMPELGAFFAILQDMRNTIMASKSVGTSEEKLKKKSAFYQSYLRRTQSMGIQLDQKIIILYMSHWGREAVNHFHLGDDMDPELRELAQTLVDIKVREISNQEPLKL
What is the function of this protein?
Encapsidates the genome protecting it from nucleases (Probable).  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (Probable).  The nucleocapsid has a left-handed helical structure (By similarity).  As a trimer, specifically binds and acts as a chaperone to unwind the panhandle structure formed by the viral RNA (vRNA) termini (PubMed:15650206, PubMed:15254200, PubMed:21378500, PubMed:16971445, PubMed:25062117, PubMed:16775315).  Involved in the transcription and replication initiation of vRNA by mediating primer annealing (PubMed:20164193).  Plays a role in cap snatching by sequestering capped RNAs in P bodies for use by the viral RdRp during transcription initiation (PubMed:19047634).  Substitutes for the cellular cap-binding complex (eIF4F) to preferentially facilitate the translation of capped mRNAs (PubMed:18971945, PubMed:25062117).  Initiates the translation by specifically binding to the cap and 40S ribosomal subunit (PubMed:20844026, PubMed:20164193, PubMed:25062117).  Prevents the viral glycoprotein N (Gn) from autophagy-dependent breakdown maybe by blocking autophagosome formation (By similarity).  Inhibits host EIF2AK2/PKR dimerization to prevent PKR-induced translational shutdown in cells and thus the activation of the antiviral state (By similarity).  Also displays sequence-unspecific DNA endonuclease activity (PubMed:27261891).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the hantavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm, host perinuclear region. Host Golgi apparatus, host cis-Golgi network. Note=Internal protein of virus particle.
Protein: MBNL2_HUMAN
Sequence: MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPAIGTNTAISFAPYLAPVTPGVGLVPTEILPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTSDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMAFPPGALHPLPKRQALEKSNGTSAVFNPSVLHYQQALTSAQLQQHAAFIPTGSVLCMTPATSIDNSEIISRNGMECQESALRITKHCYCTYYPVSSSIELPQTAC
What is the function of this protein?
Mediates pre-mRNA alternative splicing regulation.  Acts either as activator or repressor of splicing on specific pre-mRNA targets.  Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle.  Antagonizes the alternative splicing activity pattern of CELF proteins.  RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3.  Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs.  Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques.  May play a role in myotonic dystrophy pathophysiology (DM).
What are the official names of this protein?
Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, Muscleblind-like protein-like 39.
What is the protein family that this protein belongs to?
Belongs to the muscleblind family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques (PubMed:16273094). Location in the cytoplasm is microtubule-dependent (PubMed:16273094). In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts (PubMed:11929853).
Protein: MYPR_PIG
Sequence: MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
What is the function of this protein?
This is the major myelin protein from the central nervous system.  It plays an important role in the formation or maintenance of the multilamellar structure of myelin (By similarity).
What are the official names of this protein?
Myelin proteolipid protein, PLP, Lipophilin.
What is the protein family that this protein belongs to?
Belongs to the myelin proteolipid protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Myelin membrane. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.
Protein: NUSB_COXBR
Sequence: MINKTRHNARRYALQALYQWFFCETKPDALISQFMEEHDLSDTDVAYFKEVVTGTIQHVAIIDELMTAHLDRKISALNPVELSVLRLSIYELLHRKEVPYKVVIDEALELVKEFGAEAGHKYVNAILDVLSSEIRKGV
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: EIF1A_DROPS
Sequence: MHRSHPSTTRRKHLIKEMMEDDYELPTEQQQIVRVVRSCGNNLHEVETATPESENFLVSMPNKYRKNMWVKRGDFLLVEPIEEGDKVKAEISKILTNDHVKEYTKAGIWPERFAKNPPQEAKAQNDDEDSDFEDDLTPNTNRPVQESDEEDEDTDTESSDEED
What are the official names of this protein?
Probable RNA-binding protein EIF1AD, Eukaryotic translation initiation factor 1A domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the EIF1AD family.
Protein: CCE1_YEAST
Sequence: MSTAQKAKILQLIDSCCQNAKSTQLKSLSFVIGAVNGTTKEAKRTYIQEQCEFLEKLRQQKIREGRINILSMDAGVSNFAFSKMQLLNNDPLPKVLDWQKINLEEKFFQNLKKLSLNPAETSELVFNLTEYLFESMPIPDMFTIERQRTRTMSSRHILDPILKVNILEQILFSNLENKMKYTNKIPNTSKLRYMVCSSDPHRMTSYWCIPREETPTSSKKLKSNKHSKDSRIKLVKKILSTSILEGNSTSSTKLVEFIGVWNNRIRNALTKKKSFKLCDILEIQDNSGVRKDDDLADSFLHCLSWMEWLKNYESITELLNSKTLVKTQFGQVFEFCENKVQKLKFLQNTYNND
What is the function of this protein?
Capable of resolving Holliday junctions.  Specific for 4-way junctions.  Seems to be important for the maintenance of mitochondrial DNA.  Cleaves fixed junctions at the point of strand exchange.  Cleaves after 5'-CT-3' sequence.
What are the official names of this protein?
Cruciform cutting endonuclease 1, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RRF_HYDS0
Sequence: MIEDILEEAEESMKKSINHFKSELAGFRTGRASTSLVEDIKIEYYGSRVPIKQVGNVSVPEPNQILIQVWDQNAISPIEKAIMEQLSLNPARQGNTLRITLPPLTQERRKELVKLLHKTTEEAKVAIRNIRRDAKEMIESLEGISEDEIKRALDKLQKITDHYIDEISNLSSSKEKEITELK
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TES_CHLAE
Sequence: MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVSYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKMMS
What is the function of this protein?
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton.  Plays a role in the regulation of cell proliferation.  May act as a tumor suppressor (By similarity).
What are the official names of this protein?
Testin.
What is the protein family that this protein belongs to?
Belongs to the prickle / espinas / testin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
Protein: RUVC_ECO55
Sequence: MAIILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.