PharMolix/UniProtQA huggingface dataset:
Protein: COX1_PANPA
Sequence: MFTDRWLFSTNHKDIGTLYLLFGTWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIQFAIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNVLSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSANLEWLYGCPPPYHTFEEPVYMKS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RK19_PHATC
Sequence: MLKLKTQKVIDAIESKFIKKDLPTLKIGDNVRIGVKIIEGTKERVQFYEGTIIAKKNSSINMTITVRKILQGIGIERVFLVHSPKIDSITVLRSSKVRRAKLYYLRNLRGKASRLKQTFK
What are the official names of this protein?
50S ribosomal protein L19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IRC22_ASHGO
Sequence: MKLSNLLLFANVGTLLVKATDENISPNEENTPRYAQFNIDYSVLDQPNYDPMAPMEFENGENITLAFNFANNEEVPVKLIAVGGNIINARSGDEVANITRSSLGEIEVDVNTSVSFNQAINLKLDEGDYFLLPNVFVLKEGELMAVGTSPSRIKILPPPMSFFNPKFLSIQAVLIGVISYFTYFIFRSSKKERRGVVSKTKAPKKVKLDESWLPENHLKK
What is the function of this protein?
Is probably involved in a pathway contributing to genomic integrity.
What are the official names of this protein?
Increased recombination centers protein 22.
What is the protein family that this protein belongs to?
Belongs to the IRC22 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RNPH_BACHK
Sequence: MRVDGREKTELRHIHIHTNYLKHPEGSVLIEVGDTKVICSATIEERVPPFMRGEGKGWVTAEYAMIPRATEQRTIRESSKGKVTGRTMEIQRLIGRALRAVVDLEALGERTVWIDCDVIQADGGTRTASITGAYVAMVLAFEKLLQAEKVSKIPVKDYLAATSVGIVEEQGVVLDLNYAEDSKADVDMNVIMTGKGQFVEVQGTGEEATFSRAQLNELLDAAEQGIFQLIDIQKEALGDIVSHIE
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: AGRL1_MOUSE
Sequence: MARLAAALWSLCVTTVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYIFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLAFPNPYQFVSSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPAPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKQNVVLEVTVLNTEGQVQELVFPQEYPSENSIQLSANTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGTGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQYEVACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGASGGAKGPPPEPPVPPVPGVSEDEAGGPGSADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPNEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAAPSLEGPGPDGDGQMQLVTSL
What is the function of this protein?
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells (PubMed:35907405).  Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization.  Receptor probably implicated in the regulation of exocytosis (By similarity).
What are the official names of this protein?
Adhesion G protein-coupled receptor L1, Calcium-independent alpha-latrotoxin receptor 1, CIRL-1, Latrophilin-1, Lectomedin-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Synapse. Presynaptic cell membrane. Synapse, synaptosome. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.
Protein: RS7_GEODF
Sequence: MPRRREVAKRIILPDPKYGDRVVAKLVNIIMFDGKKSTAERALYGALEIVSEKVNEEPVKILKKSLDNIKPMLEVKSRRVGGSTYQVPVEVRAERRVSLAMRWLVKYANDRSEKTVTDKLAGEILDAYNNRGAAVKKREDTHKMAEANRAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: YIDC1_LISIN
Sequence: MKKKNIILISVLLGALLLITGCSMDPSQNTDGFFSTYLIQPFTSFIMFVAKFVGGNYGIAIIITTLLIRALIMPLNLRTAKAQMGMQSKMAVAKPEIDEIQARLKRATSKEEQANIQKEMMAVYSKYNINPIQMGCLPLLIQMPILMAFYYAIRGSSEIASHTFLWFNLGSPDMVLAIIAGLVYLAQYFVSMIGYSPEQKKQMKIIGLMSPIMILFVSFTAPSALALYWAVGGLFLAGQTLLTKKLYMNKHPEIKVMEQEEKEFEQIVEEQNKEK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC 1, Foldase YidC 1, Membrane integrase YidC 1, Membrane protein YidC 1.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CHMA_BPGOS
Sequence: MGLDVRNNGNDNVEIRAAETRTAQRADEALETAADFAGQPKVTHTMRTINRTLSRRISRNTGSEQVLNLRRLMEKYLEDTRFKDDFIFVAVDPNQYSVPYPTLVVMSGAKVGDHNHFFGYVLPLVAGLAPLPRREEQGPHGNILVPRTWVDNLNGTFINEVMAAMYAAIGGKSNGTARIAGLAVVTNEITAESAHLATTLLSAADNAIQTAIEIRLGDKLGLPQFNLGMMASDQPISSVQYNTSGMQDSDIVGNPVRSDITVTISNRIRQAMSDYDSQQRLVATTGYIDLTYSPQNPTFNQGPVLVNGYPVPPTVQYQPRYVMTSAYPLELDAFTPNTFVLGLIGTIATLNSGMAWAQSLISNAARGIGPHNPGALAMVLDPEVTAPLDLSTQTNEQIYKFLQQVLYPSLLISIDVPEEGEYSWLLRMIPAAEKIYTGKVEGEVREISEGYKALYRAFDDVTLGCFSKKYQYGLPLVYATGNRIPLGHYNHQDGHRHDIRDMDDLYMMNITNPDTVEAWEDSFDRTDMTMSQRVVARHEIIDRVLSGSWEQTGWAMRYDFDPLALQALIEAAADAGFTIRPENIQHLAGTAVRGNMAARARGLGNISGNIYARSDRPNVGVNNMGGAFNLF
What is the function of this protein?
Self-assembles to forms a proteinaceous shell that encloses the viral DNA and compartmentalizes proteins and DNA during viral infection (Probable).  This micrometer-scale compartment contains narrow pores and is the site of viral replication, with the proteins involved in DNA replication localized inside (By similarity).  Provides a surface for docking of capsids during packaging (By similarity).  Probably protects the viral genome against host defenses (Probable).
What are the official names of this protein?
Chimallin, ChmA, Phage nucleus enclosure protein, PhuN, gene product 189, gp189.
Protein: COFI_YARLI
Sequence: MFQPCCSKSTMSRSGVAVNDSALQAFNELKLGKKVTFIIYKINDAKTEIVVEEEGTTDSYDTFLGKLPENDCRYAVYDFEYEISSGEGKRSKLVFFTWSPDTAPVRSKMIYASSKDSLRRALTGISTEIQGTDFSEVAYESVLERVSRGAGSH
What is the function of this protein?
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner.  It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin.  Binding to F-actin is regulated by tropomyosin.  It is the major component of intranuclear and cytoplasmic actin rods.  Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends.  In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments.  Involved in the maintenance of the contractile ring once formed.  In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).
What are the official names of this protein?
Cofilin, Actin-depolymerizing factor 1.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Note=Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.
Protein: C560_CRIGR
Sequence: MAALLLRHVGRHCLRAHLNSQICLRNAVPLGTTAKEEMERFWNKNTSSKRPVSPHLTIYRWSLPMVMSICHRGTGVALSGGVSLFGLSALLLPGNFESYLMFIKSLCLGPALIHSAKFVLVFPLMYHSLNGIRHLIWDLGKGLSISQVYQSGVAVLMLAVLSSVGLAAM
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
What are the official names of this protein?
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial, Integral membrane protein CII-3, QPs-1, QPs1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b560 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RK33_CARPA
Sequence: MAKGKDARVTIILECTSCVRNGVNKESTGISRYITQKNRHNTPSRLELRKFCPYCYKHTIHGEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SDMB_METCA
Sequence: MTTLVTGATGHLGANLVRALLARGEKVRAFIRRQSDVAALDGLAVERAYGDLRDRRSIRDALEGVERLYHTAAFVSIRDGDRQELFDVNVVGTRMLMQEARRAGVRRVVHTSSFGAVGINPQGASNEHWTVSPFEPGTDYERTKAVSEHDVILEAVRGLDVTIVNPAAIVGPWDFRPSLVGRTILDFAHGRMRAFVPGAFDFVPMRDVVAVELLAMDKGIRGERYLVTGEHCTIGQILQWLEELTGHPRPRLAIPPRLMQGIALLKDPLERRFFPRRTPRFNYHSIRLLNSGKRGDSSRSRRELGLVPTSTRAAFADAVAWFRERGMI
What is the function of this protein?
Participates in the biosynthesis of bacterial sterols (PubMed:29784781).  Together with SdmA, removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules (PubMed:29784781).  SdmB catalyzes an oxidative decarboxylation that results in reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group (PubMed:29784781).  It also functions as a ketoreductase that converts the C-3 oxo group back to a hydroxyl group after C-4 demethylation (PubMed:29784781).
What are the official names of this protein?
Sterol demethylase protein B, 3beta-hydroxysteroid 3-dehydrogenase, 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating).
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: PTMA_STACT
Sequence: MTELFSNENIFLNQSFEDQNEAIEKAGQALVDAGAVTEDYIQAMKDREAVVSTFMGNGLAIPHGTDEAKSAVLQSGLTLLQIPEGVQWGDDVAKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVNTKSPEEIKAVFEEADV
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II CmtAB PTS system is involved in D-mannitol transport.
What are the official names of this protein?
Mannitol-specific phosphotransferase enzyme IIA component, EIIA, EIII, PTS system mannitol-specific EIIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_FRAT1
Sequence: MTNISVIAKPYAKAAFEFANEHNLLQQWSKLLQTFSELIKDKSVAAIVSSPTISQIEVVDALKKQLDENFFNFLALIAENKKMLIMPEIADQFESIKNIHNNVRVADVTLAYATDKNILDSLKTSLEKKFGCTIDMHINIDPAIIGGAVVKVGDTVIDSSVSGHLEKLKSILLS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL1_ANAPZ
Sequence: MLDKNIVYTPEEGIDQLLKSTTARFKESVDVAIKLSTGDSRSGDSIRGVAVLPKGLGREVRVAVLAKGEYAKQAKDAGADVVGDSDLIEEIKKGRKLDFDWCIATPDFMSQVSAIAKILGPRGLMPNPKFGTVTFDIAKMVGIVKSGQVRFRSDKYGIVHVKIGDVGFSREDLMENLRAVVSAVQGLKPATVKGAFFKAVFLNSTMGKSFRITGLG
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PYRD_XYLF2
Sequence: MYSLFRPLLFTCDAERAHDISLRTLDIAYHSGALPLLTRHTRPLPTTAFGLNFPNPVGLAAGLDKNGTHIDALFALGFGFIEIGTTTPRPQAGNPKPRLFRLTQQQAVINRMGFNNLGVDALVRNVAGARRRNGPLGINIGKNKDTPNEQASNDYRYCLERVYALADYVTINLSSPNTAGLRALQEEQTLRRLIGELRETQETLAAKHGRHVPMLIKMAPDLSDSDIDAAARVLNEMSVDGVIATNTTVTRPLLRQHPLASEAGGLSGAPLLGQSTLVLRRLRTHLPETIDLIGVGGICCGADAGAKMAAGASLVQCYTGLIFKGPQLVGECVEAIRRRLEASSSGRENTQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DPB2_DEBHA
Sequence: MENPSALPIKLQPSNLRPIAYRILSKKHGLNIQTDALKLLTDAVSYKFGFDWKSTQSQQFLEEIAKIWKKQDRGIFIDGPGLKQVIKELSDRNTNQISTRNGSADNLAKKAERSDTLVDNDAENEPVNNAENTLNWQDYFKVINPDEQPNYKYDKHRKQLSFIPSTNAKRLANNLNSNVDYFNNRYHLISDRLSRNENFQKPSFSSISSISKSLSHNNKTNEITLIKNVLGRDGSKFILFGLLSKNANDDFILEDSTDHIELNLTQAYKTEGSFYCPGMFVIVEGIYSASGGSMSNANVIGGCFHVSNIGHPPAERRELSMENYGNLDFMGINRDNDTNNNDNHILRVNKSLKKKLVSLEKTLVNHKLIILGSDCFLDDLKILDGIKKLFGKIESSLIDDETNQPLVIVLIGSFTSNPLTPTNSSVANVSNTENYKSNFDNLSNILSNFPNIVQKVKIALIPGINDPWQSSHSLGGSNLNAFPQRSIPKIFTNRLERLLPKGNLIAGWNPLRINYLSQEIVLMKDDIINKFKRNDIIFSNDLELEQLKLQKDKNDDGLIHATDINTKEPHISPKIKQARKLVKTILDQGNLQPFLKDIRIINTNFDYSLRIEPLPTILILNDATFPTFEVTYNGCKVINTGKLVGNNRKLSFVEYFPSGKKFEFKEVYF
What is the function of this protein?
As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.
What are the official names of this protein?
DNA polymerase epsilon subunit B, DNA polymerase II subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase epsilon subunit B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL27_LISMF
Sequence: MLKFDIQHFAHKKGGGSTSNGRDSESKRLGAKRADGQFVTGGSILYRQRGTKIYPGTNVGRGGDDTLFAKTDGVVRFERMGRDKKKVSVYPEVQEA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RSEP_YERPE
Sequence: MMSILWSLAAFIVALGILITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRQGTEYVIALIPLGGYVKMLDERVEAVAPELRHQSFNNKTVLQRAAIVSAGPIANFLFAIVAYWLVFIIGVPSVRPVIGDISPQSIAAQANISSGMELKSVDGIETPDWDSVRLALISRIGDKQMQVGVAPFGSDNVVEKTLDLRQWQFEPDKQDPVVALGIIPRGPQIESVLAEVQPGSAAQKAGLQAGDRIVKVNGQLLDRWQTFVLQVRDNPGQPLVLDIERESTPLSLTLIPDTKSVGENRSEGFAGVVPKVIPLPDEYKTIRQYGPFTAVYQAGDKTWQLMRLTVSMLGKLITGDVKLNNLSGPISIAQGAGLSAEYGLVYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL
What is the function of this protein?
A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA.  Part of a regulated intramembrane proteolysis (RIP) cascade.  Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA.  This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA (By similarity).
What are the official names of this protein?
Protease RseP, S2P endopeptidase, Site-2 protease RseP, S2P protease RseP, Site-2-type intramembrane protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PANC_CHLCH
Sequence: MQIISDPHAMQAISENVRLQGKRLAVVMTMGALHEGHISLVTLARKSADTVIMTLFVNPTQFSAGEDLERYPRPFEQDVAHAEAAGVDYLFAPTSAEMYPAGHQTSVQCGALAERFEGAHRSGHFNGVATVVTKLLHITKPHTAIFGEKDAQQLAIIRQLVADLLIDVEIIGAPIVREADGLAKSSRNIYLSSNERKRATVLYGGLCHAKARLAEGEQNLKLIATEVEALITATEGCTIDYVAFVDEATFLPIEQADASKRYRLLLAVRLGSVRLIDNMVMGTKDSYKPC
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_CORGL
Sequence: MATTADFKNGLVLKNEGKLQQIIEFQHVKPGKGPAFVRTKLKDVVTGKTIDKTWNAGVKVETATVDRRDVTYLYNDGTSFIVMDDKTFEQYELSPDAFGDAGRFLLENMRVQVSFHEGEALFGELPVSVDLRVEHTDPGLQGDRSTGGTKPATLETGAEIQVPLFIETGNVLKVDTRDGSYLSRVNN
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_ROTSP
Sequence: MGKYNLILSEYLSFIYNSQSAVQIPIYYSSNSELENRCIEFHSKCLENSKNGLSLRKLFVEYNDVIENATLLSILSYSYDKYNAVERKLVKYAKGKPLEADLTVNELDYENNKMTSELFPTAEEYTDSLMDPAILTSLSSNLNAVMFWLEKHENDVAEKLKVYKRRLDLFTIVASTINKYGVPRHNAKYRYEYDVMKDKPYYLVTWANSSIEMLMSVFSHDDYLIAKELIVLSYSNRSTLAKLVSSPMSILVALVDINGTFITNEELELEFSNKYVRAIVPDQTFDELNQMLDNMRKAGLVDIPKMIQDWLVDRSIEKFPLMAKIYSWSFHVGFRKQKMLDAALDQLKTEYTENVDDEMYREYTMLIRDEVVKMLEEPVKHDDHLLRDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDMANERYTPGIIPPVNVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLIYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNTMVLYTDVSQWDSSQHNTQPFRKGIIMGLDILANMTNDAKVLQTLNLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRISNKHSFATKIIRVDGDDNYAVLQFNTEVTKQMIQDVSNDVRETYARMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYSNYIVNRLRGFETDREFILTKIMQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTVDEVYIQRAFMSLSSQKSGIADEIAASSTFKNYVTRLSEQLLFSKNNIVSRGIALTEKAKLNSYAPISLEKRRAQISALLTMLQKPVTFKSSKITINDILRDIKPFFTVSDAHLPIQYQKFMPTLPDNVQYIIQCIGSRTYQIEDDGSKSAISRLISKYSVYKPSIEELYKVISLHENEIQLYLISLGIPKIDADTYVGSKIYSRDKYRILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEVINYAIKNGSWISLFCNYPKSEMIKLWKKMWNITSLRSPYTNANFFQE
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription.
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).