PharMolix/UniProtQA huggingface dataset:
Protein: EMC5_YEAST
Sequence: MSFVSKLLYTVSALVLFHSGFSSYEFHHLLKLNSLNNAQGAISKLPKDIMYETYAGLILFVLAVFTSFEKLQYLPIESNDGKIISQGNYLKEIALNKATNVDNLIGSNPNGEIIFTPSFVDVHMKRKICREWASNTVKKEK
What is the function of this protein?
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151).  Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151).  Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151).  It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes.  By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity).
What are the official names of this protein?
ER membrane protein complex subunit 5, Killer toxin-resistance protein 27.
What is the protein family that this protein belongs to?
Belongs to the membrane magnesium transporter (TC 1.A.67) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ISDC_STAA8
Sequence: MKNILKVFNTTILALIIIIATFSNSANAADSGTLNYEVYKYNTNDTSIANDYFNKPAKYIKKNGKLYVQITVNHSHWITGMSIEGHKENIISKNTAKDERTSEFEVSKLNGKIDGKIDVYIDEKVNGKPFKYDHHYNITYKFNGPTDVAGANAPGKDDKNSASGSDKGSDGTTTGQSESNSSNKDKVENPQTNAGTPAYIYAIPVASLALLIAITLFVRKKSKGNVE
What is the function of this protein?
Involved in heme (porphyrin) scavenging.  Binds hemoglobin and almost exclusively free-base protoporphyrin IX.  Probably has a role as the central conduit of the isd heme uptake system, i. e.  mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF.  Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor.  The reaction is reversible (By similarity).
What are the official names of this protein?
Iron-regulated surface determinant protein C, Staphylococcal iron-regulated protein D.
What is the protein family that this protein belongs to?
Belongs to the IsdC family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Partially protected from extracellular protease in situ (PubMed:15718231). Anchored to the cell wall by sortase B (PubMed:11830639, PubMed:15718231) (Probable).
Protein: TABA_ECOLI
Sequence: MIIGNIHNLQPWLPQELRQAIEHIKAHVTAETPKGKHDIEGNRLFYLISEDMTEPYEARRAEYHARYLDIQIVLKGQEGMTFSTQPAGAPDTDWLADKDIAFLPEGVDEKTVILNEGDFVVFYPGEVHKPLCAVGAPAQVRKAVVKMLMA
What is the function of this protein?
Influences biofilm formation.  Represses fimbria genes in 8 hours biofilms.  May act in response to the combined activity of several toxin-antitoxin (TA) systems.
What are the official names of this protein?
Toxin-antitoxin biofilm protein TabA.
What is the protein family that this protein belongs to?
Belongs to the TabA/YiaL family.
Protein: JAG2_HUMAN
Sequence: MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
What is the function of this protein?
Putative Notch ligand involved in the mediation of Notch signaling.  Involved in limb development (By similarity).
What are the official names of this protein?
Protein jagged-2, Jagged2, hJ2.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: NU4C_MAIZE
Sequence: MSYFPWLTILVVLPIFAGSLIFFLPHKGNKIVRWYTIAICLLEFLLMTYAFCYHFQLEDPLIQLKEDSKWIDVFDFHWRLGIDPLSLGSILLTGFITTLATLAAWPVTRNSQLFYFLMLAMYSGQIGLFSSRDLLLFFIMWELELIPVYLLLSMWGGKRRLYSATKFILYTAGGSIFFLIGVLGMGLYGSNEPGLDLERLINQSYPTTWEILLYFGFLIAYAVKLPIIPLHTWLPYTHGEAHYSTCMLLAGILLKMGAYGLIRVNMELLPHAHYLFSPWLVIIGAVQIIYAASTSLGQRNFKKRIAYSSVSHMGFIIIGIGSITNIGLNGAILQILSHGFIGATLFFLAGTACDRMRLVYLEELGGISIPMPKIFTMFSSFSMASLALPGMSGFVAELVVFFGLITSPKFMLMPKMLITFVMAIGMILTPIYLLSMLRQMFYGYKLFHVPNKNFVDSGPRELFLLICIFLPVIGIGIYPDLVLSLSVDRVEVLLSNYYTK
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RLMC_HALNC
Sequence: MHCAYFERGTCRSCGWLADPYADQLQRKMARCQSALTGLGGVWLPIVPSAETAFRNKAKMVVCGDASSPCLGILDADDDGIDLSNCPLYPTAITEAFEPLKQMIRRLGIPPYDVKKRQGELKYLLITVSEDDDSLMVRLVLRSDIWIERLRADLSTLTADLPHLAVLSVNIQPVHQAILEGEQEVILTDRETLTVHLNGLPFHLRPKSFFQTNTRVAEQLYATARSWVAEVAPVHMWDLFCGVGGFALHCADVIPGQVTGIEISAEAIASAQQSALELGLKNVSFHALGANEFIDQAVSLPQMPALVVVNPPRRGLGVGLCAFLDESVVQTVIYSSCNPESLARDLVMMPGFELVKAQVFDLFPHTAHSEVLAMLVRVR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: PTH_METI4
Sequence: MGVFHIVVGLGNPGQEYEKTRHNIGWRVVEELVKRQNLSFKIDKKAKSKVAFKEKLVFVLPLTYMNLSGQALSYLLQKEKCSSKDILVILDDISLPLGKLRFRPKGSSGGHKGLESIIEELHTEDIPRLRLGIGPLPEGEQLADYVLKPFLEEEKDKVEEMILKAIQFFECLQKEGIEIALNKLSA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL332_PEDPA
Sequence: MSQKKVALACTVCGSRNYTVAANPQRTDRLEVNKYCKRCNKHTLHSETR
What are the official names of this protein?
50S ribosomal protein L33 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PP12_ARATH
Sequence: MAQQGQGSMDPAALDDIIRRLLDYRNPKPGTKQAMLNESEIRQLCIVSREIFLQQPNLLELEAPIKICGDIHGQYSDLLRLFEYGGFPPTANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFSVRLWKVFTDSFNCLPVAAVIDDKILCMHGGLSPDLTNVEQIKNIKRPTDVPDSGLLCDLLWSDPSKDVKGWGMNDRGVSYTFGPDKVAEFLIKNDMDLICRAHQVVEDGYEFFADRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADRKPRFL
What is the function of this protein?
Serine/threonine-protein phosphatase that possesses phosphatase activity toward para-nitrophenyl phosphate (pNPP) in vitro.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1 isozyme 2, Type one protein phosphatase 2.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly localizes in the nucleus.
Protein: POL1_BAYMJ
Sequence: MEQTLAQAVSRKSKTDTPMAEERKHFSPMNFSANFVAPELFYSANVRKIKNIFRERSTTRFLDAISSDFELVAFLTLSPAHLMQLETVLRHEMRSCVVPIVTSDASFETVAVIKTALDGMRFHFGYTTLEKGWISMMRHAESCLQESSSSAVNDLQTQIKRVGSLLLSGKNRVEGCELSVLNLTARRFRIEYGLNGTYFGEHVAMLRGLKRYIYGTVPKEFLWAKTKKHSLFTIPAWIKRTPIDCFLFCLRVIPILHRCGVAVSLIYWSCAAALNFPAFMSFLFKRQFAKYLAHSFAKHSIYFMFLTIVAILWSFRTFTSQKPKIVLQARSTAEKEKKLMMILASVVGITYLFDYDIAEALGNCLHKISRLSSYLLDDHQGIASRMFGASYGLQAGDSAEDAVTTIISDLLSVTFKIVDEDASQGTVEDASETTFHSWVGVNTLAGRNMSRPLQYSVNETYALTPQNVQLQARKMADANNCWSMVVGHTGSGKSTYLPVQYSNYLSTKSDRRQQILICEPTQAATENVCAGVAANLGRAVYGRHEGWSRMGDHCIQVMTYGSALQCHAMDPSFISTFDAIFLDEAHDVKEHSLVFESICDTFKSVRKFYVSATPRDGSVCPEAARKYPLHVETSVCDSYRKFIAAQGGGDLLDISKHDTALVFLAGRPECIKAANAWNASVTGEKRAFSLSSDNFATDFSMLTERLKTHKTIIFTTNIIETGVTLSVDCVVDFGHTMRPCLDLNQKALRLDRRRVTRNERQQRIGRAGRLKDGYAIVCGDVDRAVNVISPDVLYGAALLSFKHNVPFYMNETFESSWLEGITKAQADTMTIFKLPIFLTRDLINADGSVAKEFLDVLKKHQFTTSDIKQAPSVTAKHIFPTWASYFSLHQALHYGDDKDEVPHELRYARVPFSVTTLSKFDWPALALACEKHRASMSNVFAGIEEPARVVTLQTNPANIQASITHLTHMSKNYKTLIENNQHVRQSMVTNVMYKWFSSTRITKDLDRNLRRCTDNLAVVEATLSSLRQILAGNTQVHATPHMQSTLEDIIGLQASDTLTEESLASALGIFVPKSNLFLLLATKGFKLVYVVCILLLVNLVYLGLRKWREHLKQKGSNEILTNTMPVSEGGEILAEVMKMEPKMRKNIKKDMDAAVESKLCGFTFVFPDDDKIGLEGKGNKYRPREDARLMYSTREDATLDAWNEKAKERRKKVTDKSEPELRRAYEKRPYFNFYDLQTDSNILEAIFYTTEGDEFFRTADPNKDMNLVADKLRSFLDTKLVVGHHQRQMLEETAKVVIKDTKGTAHHMDISQHDPDHLKQNGSGKIGYPEHRGQFRQEGPAKTADYDLGVEFGTDTDDITLEASTGILLSQVGVDVATRVGRIFIGTFNMNCYFYSDWILVPGHLQDRSGNVTIQFPDQTVQTTTDALNANGVKRFYGLDVIAIRRPAILRPRTKLVKAFAIEEPVIAQMVFVDAQGVRKFTQSVRARKEENSGRWSHKISTVLGMCGCQFWTLERQIDGIHVATNYTKKRNEFQPFTQEVVDFINGPGTKIPYCPWVFDRPACGYASHTALFEKPTTLTDIIHMQASDGLHNINNAIEGFGSSLRGQLVSPPTESTRQRFDKLFGSGSFELIGQMNKGLIDKHVIVGENDDVHDFMREHPTFTWLKDFMNEYAPSVLSYSAYYKDLCKYNRAKHVLTYNPEELHYATKGLIKMLEDAGLTQGSVRTPQQVISDIQWNTSAGPSYQGKKRDLCAHLSDDEVLHLAEVCRQQFLEGKSTGVWNGSLKAELRTIEKVEAEKTRVFTASPITSLFAMKFYVDDFNKKFYATNLKAPHTVGINKFGRGWEKLHDKLNRPGWLHGSGDGSRFDSSIDPLFFDVVKTIRKHFLPSEHHKAIDLIYDEILNTTICLANGMVIKKNVGTQRQPSTVVDNTLVLMTAFLYAYIHKTGDRELALLNERFIFVCNGDDNKFAISPQFDEEFGHDFSPELVELGLTYEFDDITSDICENPYMSLTMVKTPFGVGFSLPVERIIAIMQWSKKGGVLHSYLAGISAIYESFNTPKLFKSIYAYLLWLTEEHEAEILAAMTQSSTALPIPSMLDVYRLHYGDDEIWLQAADPLTDAQKEDARIAAADGARFELADADRRRKVEADRVEAARVKKAADAALKPVNLTATRTPTEDDGKLKTPSGARIPSSAADGNWSVPATKQVNAGLTLKIPLNKLKSVPKSVMEHNNSVALESELKAWTDAVRTSLGITTDEAWIDALIPFIGWCCNNGTSDKHAENQVMQIDSGKGAVTEMSLSPFIVHARMNGGLRRIMRNYSDETVLLITNNKLVAHWSMKHGASANAKYAFDFFVPRSWMNPQDIEVSKQARLAALGTGTYNTMLTSDTTNLRKTTNHRVLDSDGHPELT
What is the function of this protein?
An RNA-dependent RNA polymerase that plays an essential role in the virus replication.
What are the official names of this protein?
Genome polyprotein 1.
What is the protein family that this protein belongs to?
Belongs to the bymoviruses polyprotein 1 family.
What are the subcellular locations of this protein?
[6 kDa protein 1]: Host cytoplasmic vesicle. Note=Probably colocalizes with 6K2-induced vesicles associated with host chloroplasts. SUBCELLULAR LOCATION: [6 kDa protein 2]: Host cytoplasmic vesicle. Note=6K-induced vesicles associate with host chloroplasts. SUBCELLULAR LOCATION: [Coat protein]: Virion.
Protein: RSXB_ECOHS
Sequence: MNAIWIAVAAVSLLGLAFGAILGYASRRFAVEDDPVVEKIDEILPQSQCGQCGYPGCRPYAEAISCNGEKINRCAPGGEAVMLKIAELLNVEPQPLDGEAQEITPARMVAVIDENNCIGCTKCIQACPVDAIVGATRAMHTVMSDLCTGCNLCVDPCPTHCISLQPVAETPDSWKWDLNTIPVRIIPVEHHA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rsx electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: PRVB4_MERAA
Sequence: AFAGVLADADIKAALAGCAAADSFNYKTFFKFFAIIDQDHSGFIEEEELKLFLQTFSAGARALSDAETK
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin beta 4.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: ATPB_PROM0
Sequence: MVATPSTSSQTKGVVRQVIGPVLDVEFPAGKLPKILNALRIEAKNPAGQDIALTAEVQQLLGDHRVRAVAMSGTDGLVRGMEAIDTGAPISVPVGEATLGRIFNVLGEPVDEQGPVNTKDTAPIHRAAPKLTDLETKPKVFETGIKVIDLLAPYRQGGKVGLFGGAGVGKTVLIQELINNIAKEHGGVSVFGGVGERTREGNDLYEEFKESGVINADDLTQSKVALCFGQMNEPPGARMRVGLSALTMAEHFRDVNKQDVLLFVDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGELQERITSTLEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLARALAAKGIYPAVDPLDSTSTMLQPSVVGDEHYKTARAVQSTLQRYKELQDIIAILGLDELSEEDRLTVDRARKIEKFLSQPFFVAEIFTGMSGKYVKLEDTIAGFNMILSGELDDLPEQAFYLVGNIDEVKAKAEKIKSEK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: RISB_MYCLE
Sequence: MSGGAGIPEVPGIDASGLRLGIVASTWHSRICDALLAGARKVAADSGIDGPTVVRVLGAIEIPVVVQELARHHDAVVALGVVIRGDTPHFDYVCNSVTQGLTRIALDTSTPVGNGVLTTNTEKQALDRAGLPTSAEDKGAQAAAAALTTALTLLNLRSRI
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: ASPG_LUPAN
Sequence: MGGWSIALHGGAGDIPFSLPPERRQPREEGLRHCLQIGVEALKSQKPPLDVVELVVRELENIQHFNAGIGSVLTNSGTVEMEASIMDGKTMKCGAVSGLSTVLNPISLARLVMDKTPHIYLAFQGAQDFAKQQGVETVDSSHFITAENVERLKLAIEANRVQVDYSQYNYPQPAQDDAEKELPLANGDSQIGTVGCVAVDSHGNLASATSTGGLVNKMVGRIGDTPLIGAGTYANELCAVSATGKGEAIISATVARDVAALMEFKGLSLKEAADYVVHERTPKGTVGLIAVSAAGEIAMPFNTTGMFRASATEDGYSEIAIWPTT
What is the function of this protein?
Acts in asparagine catabolism but also in the final steps of protein degradation via hydrolysis of a range of isoaspartyl dipeptides.
What are the official names of this protein?
Isoaspartyl peptidase/L-asparaginase, L-asparagine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the Ntn-hydrolase family.
Protein: PMP3_ASHGO
Sequence: MNSTKVVNVIIAIFLPPVAVFLARGWGVECIVDLLLTIFFFFPGMLYALYIVLTS
What is the function of this protein?
Plays a role in the regulation of membrane potential.  Could mediate a proton leak (By similarity).
What are the official names of this protein?
Plasma membrane proteolipid 3.
What is the protein family that this protein belongs to?
Belongs to the UPF0057 (PMP3) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PB2_I30A0
Sequence: MERIKELRDLMSQSRTREILTRTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIIETIPERNEQGQTLWSKTSDAGSDRVMVSPLAVTWWNRNGPTTSTVHYPKIYKTYFEKAERLKHGTFGPVHFGNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLMITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQLYTPGGEVRNDDVDQSLIIAARSIVRRATVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKKEEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFINRANQRLNPMHQLLRHFQKDAKVLFQNWGIEPIDNVMGMIGILPDLTPSTEMSMRGVRISKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEVNGPESVLVNTYQWIIRNWETVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPKQSRMQFSSLAVNVRGSGMRILVRGNSPVFNYNRTTKRLTVLGKDAGALTEDPDEGTTGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: CRCB_NITMS
Sequence: MKGLEFVFLAAGSVLGAFLRYKITESPLIFNTLPLNVLIVNVIGAFILGVFIVLSQQWNLDGRYSLFAAIGFCGSLTTMSSFALDSSNLLENNQYGALAANIIVNVGLSIGALIGGKSLMSTIISN
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIBA_PSEP1
Sequence: MPVVFVAASKLPTPFATFTMHGFLDEATGREHVVLSLGDIADGQPVLGRLHSECLTGDALFSQRCDCGSQLEAALQAIAREGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANERLGFAADQRDYAICLPMLEHLGVKSLRLMTNNPRKVKALTDMNIVVAERVPLHTGHNPHNRYYLATKAGKLGHMLGNEHQGEVPQA
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: LPXD2_LEGPA
Sequence: MSNYQFTKPAGPFRLSELAKISGATLYEGKGETFTVSGLAKLSEATSNDLVMLHQKKYVKELKNTAARSCIIGPDYVKFAPDSMYLLVHPNPYKAFALIAQAFYPSEKSSSFIAPSAKIESTALIGSDCSIAHGAYVGNHARIGKRCKIGVNTYIGDGVTIGDNCIIEDNVSIRHAVIGSNVVVYPGARIGQDGFGFASDAEGHYKIPHAGGVIIGNDVEIGANTCIDRGSLGNTVIEDWCRLDNLVQIGHNVKIGKGSIIVAQVGIAGSTELGEHVTLAGQVGVIGHLKIGKGATVLTCSKVLRNVQPGDRVIGYPAISISDWQKQIRFLKTAIKSKNPLKS
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: FTSL_MELPT
Sequence: MAELKKMRHNHYDVPVMDEPVIASQIKKTNQKKESFQLPQKKLNKISVFEKILCILLLCSIVGIVVITIQIRTTISETMNNITEAQVKNERKKEEMLKLEQEKSELSKADRIKSIGKKQGLSEIDGNLRKVK
What is the function of this protein?
Essential cell division protein.
What are the official names of this protein?
Cell division protein FtsL.
What is the protein family that this protein belongs to?
Belongs to the FtsL family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum where it forms a ring structure.
Protein: TYW3_YEAST
Sequence: MAAQNAFEQKKRAILNEIDSTQPDLSPKGTIDELCLPIIDLINASADMVTTSSCSGRVSVFLEGTKSYNGEVKIGGKGQGGKWLYVTHDREKVIGWLDELKSKSEFSFELSGKEIPTEKVTGSIRYILYKYEPFILHVKCRDFQAASKLYNTAMSCGFRESGIGSNNLVAIRINIKLDVPLGYLDETSGTLKFFVTPEYVSVLDSLSLSKFDENTRKMQALYDRIEKELINCAPDVNSKVNITPIETKEERRERKKREGMERQRQLKSPQNVL
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway.  Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.  Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
What are the official names of this protein?
tRNA wybutosine-synthesizing protein 3, tRNA-yW-synthesizing protein 3, tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TYW3 family.
Protein: MYBI_DICDI
Sequence: MMNNQSMVRYQDGSYDFGSSPSPPVYSPIYRSPPPPPQPMYGTLPQYPRFLDNSHHQVMDNSDHEQQQQHHHHQQQQQQQQHHHQQQQQQQHHQQQQQQHHQQQQQHHHQQQQQQQQQLDKSYAPSNIVSELQRKIQFLEEEISRKRDTIEGLQSQVAKYEQEKQSEKKKQSRYWTPEEHSRFIEALSKYGHKDVKSISQYVSTRNPTQVRTHAQKYFLRIDRERGRKLESKESINGGADKDDDWLREEYNDEGSPTQYSSCSNSPTTNSVANPFSNSLIISSNNNNNSNSSNNNNNNNNNNNNNNNNNNININGSSGSNSNVNSGNSSPLIKRKREAVTITATQAKSALLYKDAVLAILPTSWTPSDYEQFSKGLISNIDQDDIHSLCKLIKENFLPMQSMENIESAYHAFQKAVLKQKDINNNNNNNNNNNNINNNNNNNINNNNSNNNNNNNNTNNNNNNNNNNNNTNNNNNNNNNNNNNSSNINNNNMNNSINNNNINNNGPNSPNLLSSQPQQINQQIIQQQLLNNNNNQNSNQNNNNNNNNNNNNIINNNNNNNNNSSNNNSNNNNNINNNNNSNNNNNGNNNSNNNNNNNNNNNNNNNNINNNNNNNNGNNINNNNNNNNNSSNQIIQQQQQVQQQQMQQQQMMMQNQIIPTLPMPSPQSQVLQSQFQPQQQMQQQMQMQYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQIYQQNLNSNSGNSSPNISSINGDFVRSPNYNNKKRPPPVNVSRPEFPVTPLSGSPSHSPAQSPHYNLNNGNNNNGNGSSNSSSYSGNQSPLGLVPSPSLSLHPPSPLITSPTSHSIRWPGPLNNTLMYDYRRMEPSHGINYVPLQQSPHAPPQQSPHFNNNSNNNNNNSNNNSNNSNNNSSGSSGINISDLNNSSDENNNSSNNSSNGSGSWHQYQATDSPTGWGMNQTITAFSNTSLSINNSQS
What are the official names of this protein?
Myb-like protein I.
What are the subcellular locations of this protein?
Nucleus.
Protein: APAH_MARMS
Sequence: MATYVIGDLQGCLTPLVQLLEQINYHPEQDKLWFAGDLINRGEESLETLRFIKSLGNNATVVLGNHDLHLLAVSHGYGKLKRGDTLAEILTAGDRDDLMDWLRHQPLFHYDEQLNTVMTHAGIPPCWDLQKAQTLAKEVEDKLKSDSVDEFFATMYGNKPNTWSDDLTGLDRLRAITNYLTRMRFCDENSKLDLESKEGINTATKGYAPWFNYPTKVPEDCHIVFGHWAALEGKTQKERIHALDTGCVWGGSLTALRLEDQQRFSTPCSINRKNP
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: SPO11_HUMAN
Sequence: MAFAPMGPEASFFDVLDRHRESLLAALRRGGREPPTGGSRLASSSEVLASIENIIQDIITSLARNEAPAFTIDNRSSWENIKFEDSVGLQMVSHCTTRKIKSDSPKSAQKFSLILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVSRRSLHILSTSKGLIAGNLRYIEEDGTKVNCTCGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQRLLDDNFCNKLSPCIMITGKGVPDLNTRLLVKKLWDTFHVPVFTLVDADPHGIEIMCIYKYGSMSMSFEAHHLTVPAIRWLGLLPSDLKRLNVPKDSLIPLTKRDQMKLDSILRRPYVTCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI
What is the function of this protein?
Component of a topoisomerase 6 complex specifically required for meiotic recombination.  Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.  The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.  Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
What are the official names of this protein?
Meiotic recombination protein SPO11, Cancer/testis antigen 35, CT35.
What is the protein family that this protein belongs to?
Belongs to the TOP6A family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS21_UREP2
Sequence: MSRGVSVEGDLEKALKKFKRISNETKKDSKRHEYYLSPRIRRKEKIKEANKYRSF
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.