PharMolix/UniProtQA huggingface dataset:
Protein: PRS46_RAT
Sequence: MACGSVDPQGLLSPPLSSARLSNVPHVEGPWFWSCGQTNISCKVVNGKVVEVGKWPWQVSILFLGMYICSGSLIHHHWVLTAAHCLQRSKNPANYTVKVGVQTLPDNSSSELLVTSIVIHENFINHMSHDIAILKLKYPVTWSPFIQPICLPEVNFKPSIGTMCWVIGWGLEKAKGAPKTPYSVQGVAVRIVNNEICNHRYQFLLLKNQKKFIGNDMLCTSPEWGLDTCQDASGSSLVCQMNKTWIQMGVVSWNFGCGRRQFPSIYTSTSHFTQWIKRQIGDLKFASMAVPSFLSPFILTGYILLVSLGSLWLL
What are the official names of this protein?
Serine protease 46, Testis-specific serine protease-6.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LEPA_STRP8
Sequence: MKQTLDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYDMSEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKIIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDEDAKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner (By similarity).
What are the official names of this protein?
Putative elongation factor 4, EF-4, Ribosomal back-translocase LepA homolog.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding elongation factor family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NH218_CAEEL
Sequence: MVASSFQHHLEPMLTQPIPCQICTYQSHGVNFNVMTCRACAAFFRRSLVCGMRYHCKTRKNDCRIDSTERHFCRLCRFQKCLQMGMKAEKIQQNRDPISSTFPGTSTEPELSEIVDPENEKSYIFHGTLYGFKSLLAEVRYIFSISRNYSDSPLTDLENGFKLITRHQKRRYIDIEDRINFQNLTDFRLGHIKNCATWLTHSSFFQSLTETENLLILKSTWHVWSWLELLSVSVEIFGNQVCEEKIVFLSEKIAVDIVKVFRYILKPLNKQEKRKVEKELNPIFHILFDDVARKLQNLKPSSLEINYMLWQLVWFVAEKVLNEDNLRHGEQYTNQLASDLHNHYKNDLHLEQYAQRVLKMMAIVKSLQKHLMNIHKIIDYADNFCNLFAMK
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-218.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURQ2_BACLD
Sequence: MRKTENTNDKSTALDEMNALDIVTLMNEEDHTVPRAITPCLPLIAEAAETIVSRFEQGGRVFTAGAGTSGRIAVLDAAELPPTFSIDESRWTGLIAGGYDAMWMPLEENEDDREKIVADLKAQSFSKDDVLIGVTASGSTPYVLGALSYAKQIGAASVSISCNADTEAGKLSDIAIEVQTGPEIIRGSTRLKAGTAQKMILNMLSTAAMVRLGRVYQNEMVNMRLLNQKLAGRAVTILMNTTGLSEDEALQALKESGNDIKAAIFMTLTNGTLEVARRCLSHENGHLKKAIQYHRKGF
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase 2, MurNAc-6-P etherase 2, N-acetylmuramic acid 6-phosphate hydrolase 2, N-acetylmuramic acid 6-phosphate lyase 2.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: BR1B_LITSH
Sequence: FLPAIVGAAGKFLPKIFCAISKKC
What is the function of this protein?
Antibacterial activity against Gram-negative bacterium E. coli.
What are the official names of this protein?
Brevinin-1Sb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
Protein: Y1280_MYCTO
Sequence: MADRGQRRGCAPGIASALRASFQGKSRPWTQTRYWAFALLTPLVVAMVLTGCSASGTQLELAPTADRRAAVGTTSDINQQDPATLQDGGNLRLSLTDFPPNFNILHIDGNNAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTRTAPQVVTYTINPEAVWSDGTPITWRDIASQIHAISGADKAFEIASSSGAERVASVTRGVDDRQAVVTFAKPYAEWRGMFAGNGMLLPASMTATPEAFNKGQLDGPGPSAGPFVVSALDRTAQRIVLTRNPRWWGARPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAARTKGISIRRAPGPSWYHFTLNGAPGSILADKALRLAIAKGIDRYTIARVAQYGLTSDPVPLNNHVFVAGQDGYQDNSGVVAYNPEQAKRELDALGWRRSGAFREKDGRQLVIRDLFYDAQSTRQFAQIAQHTLAQIGVKLELQAKSGSGFFSDYVNVGAFDIAQFGWVGDAFPLSSLTQIYASDGESNFGKIGSPQIDAAIERTLAELDPGKARALANQVDELIWAEGFSLPLTQSPGTVAVRSTLANFGATGLADLDYTAIGFMRR
What are the official names of this protein?
Uncharacterized protein MT1317.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 5 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RS7_THISH
Sequence: MSRRSEAPKRQILPDPKYKSDLLAKFINTVMKDGKKSVAERVLYGALTQIEGKKGDGIQVLEQALDNVRPRVEVKSRRVGGATYQVPVEVRPVRQNALAMRWIVDAARKRGEKSMALKLAGELMDAADSKGSAVKKREDTHRMAEANKAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: IAP4_NPVOP
Sequence: MAHVKLICVKVNGRLRVRIDDPAYRRDANCTFPKRLRREGATFAVAPKDSSLICRSKCYYYIKPDAVTVCKITVERVFTDEANDECIVCMSEPKRMVAAPCGHYTLCVTCSYRIGGQP
What are the official names of this protein?
Putative apoptosis inhibitor 4, IAP-4.
Protein: PURA_ASPTN
Sequence: MGVTIVLGSQWGDEGKGKITDMLSQQATLCCRAAGGHNAGHTIVHGSNTYDFHILPSGLISPSCVNLIGAGTVVHVPSFFKELAALEEKGLQGASKRVFIADRAHVCLDLHSVVDGLEEARLGGRKVGTTGKGIGPCYSDKAARRGIRVGEILDEALFERKLRNLESGYRARFGDLEYNVEDEITRFKEYRKILGPHIVDQLAFLQKYKDSPNTLVEGANALMLDLDHGTYPFVTSSSTGLGGAVQALSLNPTSISSIIGVVKAYTTRVGSGPFPSEQLNEFGDKLQSVGREFGVTTGRRRRCGWFDLVLCRYSQAINHYTALNLTKLDVLDDFDEIKVGVAYILPDGTRTENTIPADAEVLDKVQVEYITLPGWKSNTMGVKKYEDLPANARAYIEYIERGLGGVPVKWIGTGPARDDMICRE
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EAF2_MOUSE
Sequence: MSGPAGLAYLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASIDTSCEGNLEVGKGEQVTITLPNIEGSTPPVTVFKGSKRPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSRIQYRLEQQQQQMWNLPRTSNLVQHSPSEEKMSPTSLMDDIERELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDDDQFSPLGPRKYSSEHPSMSAGPQYRTSEADATCHRLQDHSTLLMSTLRSDLQLSESESDSED
What is the function of this protein?
Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity).  Acts as a transcriptional transactivator of TCEA1 elongation activity.
What are the official names of this protein?
ELL-associated factor 2, Ehrlich S-II transcriptional activator factor, Testosterone-regulated apoptosis inducer and tumor suppressor protein.
What is the protein family that this protein belongs to?
Belongs to the EAF family.
What are the subcellular locations of this protein?
Nucleus speckle.
Protein: PURQ_RHIME
Sequence: MKSAVVQLPGLNRDCDMIAALTKISGKAPVTVWQTETEIPDVDLIVIPGGFSYGDYLRCGAIAARMPVMQAIKAKAEQGVRVLGVCNGFQILVEAGLLPGALMRNASLKFVCREVKLEVVNADTAFTRAYAKGQVIRSPVAHHDGNYFADAETLKAIEGNGQVVFRYAEGTNPNGSVNDIAGVLNAKGNVLGMMPHPENLIESAHGGADGRGLFASALDVIAA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: END3_RICCN
Sequence: MQAQIVNKIFEIFSKNNPNPKTELIYKNDFTLLVAVILSAQATDISVNLATKSLFATYDTPEKILELGEEGLKKYIKSIGLFNSKAKNIIALCKILISNYQASVPNDFKALIKLPGVGRKTANVVLNCLFGMPTMAVDTHVFRVANRIGLAKGDTPEIVENELLQIIDTKWLTHAHHWLILHGRYICKARKPDCDICPIKEYCDYYFNLK
What is the function of this protein?
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity.  The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site.  The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
What are the official names of this protein?
Endonuclease III, DNA-(apurinic or apyrimidinic site) lyase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
Protein: RL9_ALIB4
Sequence: MKVLLIKDVKSLGKAGEIKEVADGYGKNFLIGKGLALHATTDVLNKHKAEQKKLALKEEQEIAQAKELAEKLNATKLTIKHKVGANGHLIGSVTNKEVSDALEQQFSIMIDKKNIALDNKIKTIGIYEVDCKLGHSIHAKLKIDVIAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RS14_RICAH
Sequence: MAKVSSIKKNESRKKKSQSLHNKRSALKSKIYDKNISLEERFSLVMSLAQLPRNSSSTRIRNRCELTGRPRGVTRKFGISRNKLRELIGRGLVPGVIKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: XGPT_ROSDO
Sequence: MSSKDQSRLPHEKGFHISWDQIHRDSRALAWRLDGQGPDEGAWRAVVAITRGGMAPAMIVARELDIRVVDTISVMSYHSGGGKADQRRDAKVLKAPDADMMGDGTGILIVDDLVDSGKTLELVRAQYPNAHFATVYAKPQGEPQVNTFITGVSQDTWIFFPWDMALQYVEPYRGTD
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL19_STRGC
Sequence: MNPLIQSLTEGQLRTDIPAFRPGDTVRVHAKVVEGTRERIQIFEGVVIARKGAGISENYTVRKISNGVGVERTFPIHTPRVDKIEVVRYGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: YCF3_GUITH
Sequence: MPRFQKNDNFIDKTFTVLADLVLKILPATKQEKEAFSYYRDGMSAQSEGEYAEALENYYEALRLEEDPYDRSYILYNIGLIYASNGEYVKALEYYHQALDLNSQLPAALNNIAVIYHYQGVKASEKKELDLARTLFDKAAEYWKQAIRLSPNNYIEAQNWLKTTGRSDTLTI
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: GSA_CLOK5
Sequence: MRNDKIFEESKLYMPGGVNSPVRAFKDVPLNPPVIKKGRGAYIYDEDGNEYIDFVCSWGPMILGHCDEDVVNAIKYTSENAISFGATTKIELELSKYICTTMDNIEMIRMVNSGTEATMSAVKLARGYTRRNKIIKFSGCYHGHFDDFLVEAGSGVMTEGIPGSAGVPKDSIKNTIIAEYNNLEDVKNIFNKYGSDTAAIIVEPVAGNMGVIPGRIDFLKGLRKLCDEYGSLLIFDEVMSGFRVAYKGAQSLYGIKPDITTMAKIMGGGLPCGAYGGRKDIMENLSPLGPVYQAGTMSGNPIVMAAGLATLKKLNENPDYYVKLEKLGKKLEKGIKQISKDKNIPMVINRCGAMFSIFFTSDSEVKNYKDARKCDTTIFAKFFQHMLERGIYIAPSQFEAIFLNVKHTEEHIDKFLQAVNTF
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAMKV_TAKRU
Sequence: MPFGCLTLGEKKDYNSPSEVTDKYDLGQVVKSEEFCEIFRAKDRNTLKMYTCKKFNKKDGRKVRKAAKNEIMILKMVKHHNILQLVDAFETKKEYFIFLELATGREVFDWILDQGYYSERDTSNVMRQVLEAVAYLHSLKIVHRNLKNLVYFNRLKHSKIVISDFQLAKLENGLIKDPCGTPEYLAPEVIGRQRYGRPVDCWAIGVIMYILLSGNPPFYDDGDEEDSDSRDKNLFLKILSGDYEFDSPYWDDISDSAKTLVASLMEVDQDQRLTAQEAIAHEWISGNAASDKNIKDGVCAQIEKNFAKAKWKKAVRVTTLMKRLRASEQGDTGASGLAAGATGGPPDPNMPGGSLLAASIKTALSEKAADAQTSTIPSLPQPPAARPEEQQQAQQQQQAQQQQQARCNGDVPQMLPQRKGY
What is the function of this protein?
Does not appear to have detectable kinase activity.
What are the official names of this protein?
CaM kinase-like vesicle-associated protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=May be associated with vesicular structures.
Protein: NTF3_ACRDU
Sequence: IQSTNMDQQGSLTEDSMNSFIRTLIQAGIWKNKVPKQTARAKDDTQTTVKKTEAEADAVASKEARLGFQPIVSVDAELLRQQRRFSSPRVLLSENTPLEPPPLYLTEQPVALNRTSRRKREGKSHRGEYSVCDSESRWVTDKSSAVDIRGHQVTVLGEIRMGPS
What is the function of this protein?
Seems to promote the survival of visceral and proprioceptive sensory neurons.
What are the official names of this protein?
Neurotrophin-3.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: UBP19_MOUSE
Sequence: MSAGASATGPRRGPPGLEEATSKKKQKDRANLESKDGDARRVSLPRKEPTKDELLLDWRQSADEVIVKLRVGTGPVRLEDVDAAFTDTDCVVRLPDGRQWGGVFFAEIQSSCTKVQARKGGLLQLVLPKKVPLLTWPSLLKPLGTQELVPGLQCQENGQELSPIALEPGSEPRRAKQEARNQKRAQGRGEVGSGAGPGTQAGPSAKRAVHLRRGPEGEGSMDGPGPQGDAPSFLSDSATQVEAEEKLCAPPMNTQTSLLSSEKSLALLTVEKTVSPRNDPVAPVMVQDRDPEPEQEDQVKEEMALGADPTALVEEPESMVNLAFVKNDSYEKGPDSVVVHVYVKEIRRDSSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTIFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPATRGAVGGAKVAVPTGPTPLDSTPPGGGPHPLTGQEEARAVEKEKPKARSEDSGLDGVVARTPLEHVAPKPDPHLASPKPTCMVPPMPHSPVSGDSVEEDEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQKVLPIFYFAREPHSKPIKFLVSVSKENSSASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDAVSPTDVLLCFELLSPELAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEEEKLKRCTRCYRVGYCNQFCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTSSLEAGDSEREPIQPSELQLVTPVAEGDTGAHRVWPPADRGPVPSTSGLSSEMLASGPIEGCPLLAGERVSRPEAAVPGYQHSSESVNTHTPQFFIYKIDASNREQRLEDKGETPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRASHSEHHPDLGPAAEAAASQASRIWQELEAEEEMVPEGPGPLGPWGPQDWVGPPPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR
What is the function of this protein?
Deubiquitinating enzyme that regulates the degradation of various proteins.  Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation.  Involved in decreased protein synthesis in atrophying skeletal muscle.  Modulates transcription of major myofibrillar proteins.  Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity).  Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing thier ubiquitination.  Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner.  Exhibits a preference towards 'Lys-63'-linked ubiquitin chains (By similarity).  Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis.  Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 19, Deubiquitinating enzyme 19, Ubiquitin thioesterase 19, Ubiquitin-specific-processing protease 19.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: NFUA_PSEA6
Sequence: MISISDTAQAHFCKLLEKQEPDTNIRVFVVNPGTPSAECGVSYCPPDAVESTDTTLEFNGFDAVVDAESAPFLSEAEIDFVTDQMGSQLTLKAPNAKARKVDDDAPLEERINYMIEAEINPQLASHGGKVMLMEITEKGEAILQFGGGCNGCSMVDVTLKDGIEKQMLAQFSGELTAVKDATEHEAGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: COX2_EXERO
Sequence: MSTWSMMNLQDANSPMMEQLIFFHDHTLMILLLITITIIYIISSIIMNNLTNKFIMQNQTIEIIWTIIPMIILIYMAIPSLKILYLNDEINNPLMTIKSIGHQWYWSYEYSDFKNIDFNSFMINSKNLNHFRLLDVDNRMIIPMNNQIRMLINSADVIHSWTVPSLGVKIDSVPGRINQTLMMINRPGIYFGQCSEICGMNHSFMPIVIESTSNNNFISWLKSL
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: APT_ESCF3
Sequence: MTATAQQLEYLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIDLLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPGKLPRETISETYDLEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVTDAAFIINLFDLGGEQRLEKQGITSYSLVPFPGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_CHLT2
Sequence: MAFETFSVALDKDKTLIFETGKIARQASGAVLVKMNETWVFSSACAASLSEAVGFLPFRVDYQEKFSSAGRTSGGFLKREGRPSEREILVSRLIDRSLRPSFPNRLMQDIQVLSYVWSYDGKTLPDPLAICGASAALAISEVPQNCIIAGVRVGLVGGKWVINPTRDELSASKLDLVMAGTASAVLMIEGHCDFLTEEQVLEAIAFGQTYIAKICDAIEAWQKAIGKQKNFSAVLDMPEDVQNVVSDFIREKFEKALSFRDKEALEQASKELEESVIANLVQEENSDFSLLNVKAAFKTAKSNQMRALIQDLGIRVDGRTTTEIRPISIETPLLPRTHGSCLFTRGETQSMAVCTLGGENMAQRFEDLNGDGAARFYLQYFFPPFSVGEVGRIGSPGRREIGHGKLAEKALSHVLPETSRFPYIIRLESNITESNGSSSMASVCGGCLALMDAGVPIKAPVAGIAMGLILDRDQAIILSDISGIEDHLGDMDFKVAGTAKGITAFQMDIKIEGITHKIMEQALAQAKQGRSHILNLMTQVLASPKGTVSKYAPRIETMQINTSKIATVIGPGGKQIRQIIERSGAQVDINDDGVINIAASTQESINKAKELIEGLTGEVEVGKVYNGRVTSIATFGVFVEVLPGKEGLCHISELSKQKVDNISDFVKEGDKLAVKLLSINEKGQLKLSHKATLED
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4800_TRIV2
Sequence: MSHLNIANLGEDFVAQWLQSTGWMILNRQFSCRWGEIDIIAQHTRNNQESILAFVEVKTRSPGNWDDGGRGAITLKKQAKIERTARIFLAKYPDKAEYICRFDVAIVSYQIISKQDHELSITQESVTSSSVGEYKFQLQEYIPAAFECLID
What are the official names of this protein?
UPF0102 protein Ava_4800.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: MNMA_CAUVC
Sequence: MRAAVGLPEGARIVAAMSGGVDSTVTAALLARAGYDVVGVTLQLYDHGAAISRKGACCAGQDILDARMAAERIGIPHYVLDYESRFREQVIEDFADAYLRGETPIPCVRCNQTVKFRDLLDVARDLGAEAMATGHYVQRAMPGNGGNRPELRRAADPAKDQSYFLFATTREQLDFLRFPLGGMDKPTVRAVAAGLGLSIADKPDSQDICFVPEGKYTTVIDRIRPQGAEAGDVVHLDGRVLGRHEGVTRYTIGQRRGLNIAVGDPLFVVKINADKRQVIVGPREALLTASLTLKEGSWLGAQDSLEAAAEDGQRVLARVRSTREPVPGRLAMIDGALSVVFDGAEEGVAPGQACVLYDPADPDRVLGGGFIAGTTRQMDLNAA
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_RICTY
Sequence: MLAIGITGSYASGKTFILNYLSEKGYKTFCADNCIKELYKDIVLQTQILKLLPELKYFNIRKISNLIYNDDIAREKLQNFIYPLLIDKLILFKKENTNYKFVFSEIPLLYEAKFDQYFDFVVTIYCSEEIRMQRAITRASFDINIYNKIKEIQLSQDSKIAKADFAINSGVDMLDLEKQITKLIKNLECQV
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRE_LACP7
Sequence: MEQYKKEFIEFMVDCGVLKFGDFTTKSGRKTPFFVNTGFYRTGAQLRKLGEYYAKAIHDAYGLDFDVLFGPAYKGIPLSVATAMSISEHFDKDIKYCSNRKEVKDHGDTGILLGSPISDGDKVVIIEDVTTAGTSIGETMPILSAQGNVDVVGLVVSVDRMERGQGKKSALKEIEENYGIETTAIVTMKEVVEHLYGKPYNGKVVIDDQLKQAIDAYYEQYGVEA
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.